gebhart/patrepeval huggingface dataset:
Emotional head robot with behavior decision model and face recognition (2007)

There has been a lot of research for developing intelligent robots that can effectively perform human robot interaction. Our motivation for this research is to develop a robot that can interact with people and assist them in their daily routines, in common places such as homes, super markets, hospitals or offices. In order to accomplish these tasks a robot must be human friendly showing some emotions and exhibiting a friendly character and personality. We present an emotional and behavior based intelligent head robot that performs face recognition, and effectively communicates with people by expressing emotions using a 3D character on its screen. The behavior of the robot depends on its interaction with people. Face recognition capability of our robot is a novel classification method based on Support Vector Domain Description (SVDD). This method allows the system to be trained rapidly and improve the recognition rate gradually by learning face incrementally. For the emotional behavior of the system we implement an emotional behavior decision model that defines the character of our robot and makes different behavior decisions.
Structural Damage Detection Using Wireless Sensor-Actuator Networks (2005)

Structural health monitoring (SHM) is a well-established multi-disciplinary research field, in which the goal is to develop technologies and techniques to automatically detect, localize, and classify damage in large structures. This paper is focused, starting with a simple SHM problem and a simple structure, on how wireless sensor networking technologies can help advance SHM. Specifically, a distributed damage detection algorithm is developed based on shifted spectra of response at the sensor nodes. While damage detection using frequency shifts is fairly well-understood in the SHM community, the development here adheres to sensor network architectural principles: the technique is amenable to in-network processing and duty-cycling, and can be implemented on a long-running sensor network. The efficacy is demonstrated using simulations on structural models, and actual measurements on real, albeit simple, structures
GeneTrailExpress: a web-based pipeline for the statistical evaluation of microarray experiments (2008)

Our gene expression toolbox with its interactive visualization of the pathways and the expression values projected onto the nodes will simplify the analysis and interpretation of biochemical pathways considerably.
Critical Path Analysis (1999)

Abstract The sections in this article are Algorithmic Transformations and Retiming State of the Art in Transformation Approaches for High‐Level Synthesis Extending the ERB Technique to High‐Level Synthesis The ERB‐Based Algebraic Speedup Algorithm Experimental Results Future Work and Conclusions
Steric acceleration in the reaction of aryl bromides with tributylstannyl radicals (1998)

Approximate absolute rate constants for the abstraction of bromine from a series of aryl bromides by stannyl radicals have been determined: 2,4,6-tri-tert-butylbromobenzene and 2,4,6-triphenylbromobenzene are found to be unusually reactive, most likely owing to steric acceleration.
Effect of Catalyst Deactivation on Polymerization of Electrolytes by Surface-Confined Atom Transfer Radical Polymerization in Aqueous Solutions (2006)

We have investigated the cause of catalyst deactivation observed during surface-confined atom-transfer radical polymerization of acidic monomers. Surface-tethered polyelectrolyte layers of poly(itaconic acid) and poly(methacrylic acid) were grown from self-assembled initiator monolayers of 2-bromoisobutyryl bromide terminated thiol molecules. This polymerization initiator molecule and a copper-based organometallic catalyst allowed tethered polyelectrolyte chains to be grown directly via radical polymerization at room temperature in aqueous solutions. Structural and surface properties of the layers were characterized using phase-modulated ellipsometry and external-reflection Fourier transform infrared spectroscopy. Catalyst deactivation due to generation of a coordination complex between the deprotonated acid monomers and copper catalyst during the polymerization process appears to be an important cause of chain growth cessation. Surface-initiated polymerizations performed after aging of the catalyst-containing deprotonated monomer solution revealed inhibition of polymer growth with increasing aging times. This suggests that catalyst is consumed over time by complexation with carboxylate groups of the monomer and dissociation and disproportionation in water.
Tuning Plasmonic Coupling from Touching to Near-touching Nanodimers via Nanometric Gap Size and Morphology (2023)

We observe large tunability of hybridized plasmon modes by controlling the gap size and the dimensionality of the gap regions. We present electron energy-loss spectroscopy measurements and detailed theory supporting our results.
Predictive Toxicogenomics (2003)

This chapter provides a predictive-based perspective on the scientific issues surrounding the generation and successful use of toxicogenomics in hopes of continuing and refining the debate surrounding the use of gene expression data. It reviews analysis techniques integral to a predictive program, as are the parameters that affect the construction and utility of predictive toxicogenomics models. The chapter discusses the ToxExpress™ program, Gene Logic’s proprietary approach to toxicogenomics and presents specific applications of toxicogenomics using the ToxExpress reference database, analysis tools, and visualizations. Microarray platforms provide for tens of thousands of gene expression measurements, where each of the genes being measured has an associated noise produced from the physical aspects of chip processing and from biological differences associated with individual specimens. By limiting the focus in predictive toxicology to only those genes that truly change due to toxicity, investigators can effectively increase the signal-to-noise ratio and improve the chance for successful classification of new compounds.
Efficacy and Safety of<i> Ashitaba</i> (<i>Angelica keiskei</i>) on the Patients and Candidates with Metabolic Syndrome: A Pilot Study (2012)

明日葉は日本特有の伝統的な野菜であり，ビタミン類や食物繊維，ポリフェノールを多く含む．われわれは、これまでに明日葉に特徴的に含まれるポリフェノールの一種，明日葉カルコンに注目して抗糖尿病作用などを明らかにしてきた．今回，メタボリックシンドローム該当者ならびに予備群に対する有効性や安全性をパイロット試験により評価した．9 名の被験者に 8 週間，明日葉粉末青汁を 1 日あたり 6.2 g（明日葉カルコンとして 12.3 mg）を摂取してもらい，腹部脂肪面積の測定，身体測定，血液検査，尿検査を行った．その結果，内臓脂肪面積，体重，BMI および体脂肪率において統計学的に有意な減少を認めた．また，血液検査，尿検査においては臨床上問題となる症状は認められず，有害事象も認められなかった．以上の結果から，明日葉はメタボリックシンドロームの予防に有効な，安全な食品であることが示唆された．
Association of Testosterone Levels With Anemia in Older Men (2017)

clinicaltrials.gov Identifier: NCT00799617.
Evaluation of the QT interval in patients with drug‐induced QT prolongation and torsades de pointes (2020)

Our results indicate that QT evaluation by limb leads only underestimates the incidence of diLQTS experiencing TdP and favors the screening using both limb and chest lead ECG.
Nano‐SAR Development for Bioactivity of Nanoparticles with Considerations of Decision Boundaries (2013)

The development of classification nano-structure-activity Relationships (nano-SARs) of nanoparticle (NP) bioactivity is presented with the aim of demonstrating the integration of multiparametric toxicity/bioactivity assays to arrive at statistically meaningful class definitions (i.e., bioactivity/inactivity endpoints), as well as the implications of nano-SAR applicability domains and decision boundaries. Nano-SARs are constructed based on a dataset of 44 iron oxide core nanoparticles (NPs), used in molecular imaging and nano-sensing, containing bioactivity profiles for four cell types and four different assays. Class definitions are developed on the basis of 'hit' (i.e., significant bioactivity) identification analysis and self-organizing map based consensus clustering; these class definitions enable construction of nano-SARs of a high classification accuracy (>78%) with different NP descriptor combinations that include primary size, spin-lattice and spin-spin relaxivities, and zeta potentials. Analysis of the nano-SAR performance for different class definitions suggests that H4 (i.e., class with at least four hits) is a reasonable endpoint (from a 'regulatory' viewpoint) for keeping the level of false negatives (i.e., incorrect labeling of bioactive NPs as inactive) low. The establishment of a quantitative nano-SAR applicability domain is demonstrated, making use of a probability density with the H4 class definition and naive Bayesian classifier (NBC) model (with spin-lattice relaxivity and zeta potential as descriptors). Decision boundaries are determined for the above H4/NBC nano-SAR for different acceptance levels of false negative to false positive predictions, illustrating a practical approach that may assist in regulatory decision making with a consideration of reducing the likelihood of identifying bioactive NPs as being inactive.
Faculty Opinions recommendation of Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism. (2008)

BackgroundResistance to triazoles was recently reported in Aspergillus fumigatus isolates cultured from patients with invasive aspergillosis.The prevalence of azole resistance in A. fumigatus is unknown.We investigated the prevalence and spread of azole resistance using our culture collection that contained A. fumigatus isolates collected between 1994 and 2007. Methods and FindingsWe investigated the prevalence of itraconazole (ITZ) resistance in 1,912 clinical A. fumigatus isolates collected from 1,219 patients in our University Medical Centre over a 14-y period.The spread of resistance was investigated by analyzing 147 A. fumigatus isolates from 101 patients, from 28 other medical centres in The Netherlands and 317 isolates from six other countries.The isolates were characterized using phenotypic and molecular methods.The electronic patient files were used to determine the underlying conditions of the patients and the presence of invasive aspergillosis.ITZ-resistant isolates were found in 32 of 1,219 patients.All cases were observed after 1999 with an annual prevalence of 1.7% to 6%.The ITZ-resistant isolates also showed elevated minimum inhibitory concentrations of voriconazole, ravuconazole, and posaconazole.A substitution of leucine 98 for histidine in the cyp51A gene, together with two copies of a 34-bp sequence in tandem in the gene promoter (TR/L98H), was found to be the dominant resistance mechanism.Microsatellite analysis indicated that the ITZ-resistant isolates were genetically distinct but clustered.The ITZ-sensitive isolates were not more likely to be responsible for invasive aspergillosis than the ITZ-resistant isolates.ITZ resistance was found in isolates from 13 patients (12.8%) from nine other medical centres in The Netherlands, of which 69% harboured the TR/L98H substitution, and in six isolates originating from four other countries. ConclusionsAzole resistance has emerged in A. fumigatus and might be more prevalent than currently acknowledged.The presence of a dominant resistance mechanism in clinical isolates suggests that isolates with this mechanism are spreading in our environment.
Ultrathick MoS2 Films with Exceptionally High Volumetric Capacitance (2022)

Abstract Manufacturing electrode films at an industrial‐level submillimeter thickness (≈100 µm) with superior volumetric performance is of practical significance for the commercialization of miniaturized supercapacitor systems. This work proposes a commercially scalable solvated‐ion‐intercalated hydrothermal strategy to demonstrate a record‐high volumetric capacitance (511.29 F cm −3 ) for supercapacitors based on an industrial‐level submillimeter MoS 2 film electrode (94.2 µm). The intercalated solvated Li + ions increase the amount of negative surface charge and reduce the formation energy of 1T MoS 2 , leading to a high metallic phase content of 82.7% with enhanced electrical conductivity. Together with the expanded interlayer distance (≈1.23 nm), this allows rapid electron transfer and ion transport in the excessively stacked ultrathick MoS 2 film to be simultaneously realized. Thus, the as‐fabricated MoS 2 ||graphene/carbon nanotube asymmetric supercapacitor presents both high energy and power densities, outperforms those of commercial devices, including supercapacitors with submillimeter‐thick electrodes and even micrometer‐thick electrodes.
Enhanced delay alignment method for behavioral modeling of power amplifiers exhibiting memory effects (2012)

In this paper, the impact of memory effects on the delay estimation in power amplifiers behavioral modeling applications is investigated. It is shown that conventional cross-correlation based delay estimation is affected by the presence of memory effects. This results in a delay estimation error that impacts the performance of the derived behavioral model. Thus, rather than aligning the measured input and output waveforms using the time delay estimated using the actual measured data, a time delay derived under memoryless condition is used. The proposed method is experimentally validated using a 3G Doherty power amplifier driven by 3-carrier and 4-carrier WCDMA signals. For each signal, several memory polynomial behavioral models were derived. It is demonstrated that the use of the proposed delay alignment approach results in enhanced modeling performance. For the 4-carrier WCDMA signal, the NMSE calculated for the behavioral models derived using the proposed delay alignment technique is approximately 3.5 dB better than that calculated for the behavioral models derived using the conventional time delay alignment method.
Longitudinal position matrix of the pig coronary vasculature and its hemodynamic implications (1997)

Hemodynamic analysis of coronary blood flow must be based on a statistically valid geometric model of the coronary vasculature. We have previously developed a diameter-defined Strahler model for the arterial and venous trees and a network model for the capillaries. A full set of data describing the geometric properties of the porcine coronary vasculature was given. The order number, diameter, length, connectivity matrix [m,n] (CM), and parallel-series features were measured for all orders of vessels of the right coronary artery (RCA), left anterior descending artery (LAD), left circumflex artery (LCX), and coronary venous system. The purpose of the present study is to present another feature of the branching pattern of the coronary vasculature: the longitudinal position matrix [m,n] (LPM), whose component in row m and column n is the fractional longitudinal position of the branch point on vessels of order n at which vessels of order m branch off (m < or = n). The LPM of the pig RCA, LAD and LCX arterial trees, as well as the coronary sinusal and thebesian venous trees, are presented. The hemodynamic implications of the LPM are illustrated by comparing two kinds of circuits: one, the CM + LPM model, simulates the mean data on the morphology (diameters, lengths, and numbers), CM, and LPM of vessels, whereas the other, the CM model, simulates the mean data on the morphology and CM without considering the LPM. We found that the LPM affects the hemodynamics of coronary blood flow especially with regard to the nonuniformity or dispersion of flow distribution.
Effect of Single-Walled Carbon Nanotube Concentration on the Electrical Properties of Solution-Based Indium Gallium Zinc Oxide Thin Film Transistors (2009)

Abstract In this work, we have fabricated thin film transistors (TFTs) from a solution-based indium gallium zinc oxide (IGZO) and single-walled carbon nanotube (SWNT) blend by varying SWNT concentration. In order to improve electrical performances of IGZO TFT, SWNTs were used as carrier transport rods. We found out that the saturation field effect mobility (μsat) and on/off current ratio varied when the SWNT concentration changed. The concentration of SWNT in the solution is a critical parameter to control the electrical performances of IGZO TFT. The optimized performance of IGZO TFT with 0.04 wt.% SWNT concentration is as follows: μsat of about 0.11 cm2/Vs, an on/off current ratio of ∼ 105, threshold voltage (Vth) of − 2.5 V, and a subthreshold slope (S-factor) of 4.1 V/decade. Keywords: carrier transport rodindium gallium zinc oxidesingle-walled carbon nanotubesolution processthin film transistor Acknowledgments This work was supported in part by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2006-311-2006-8-1450).
High-Frequency Operation of a DC/AC/DC System for HVDC Applications (2014)

Voltage ratings for HVdc point-to-point connections are not standardized and tend to depend on the latest available cable technology. DC/DC conversion at HV is required for interconnection of such HVdc schemes as well as to interface dc wind farms. Modular multilevel voltage source converters (VSCs), such as the modular multilevel converter (MMC) or the alternate arm converter (AAC), have been shown to incur significantly lower switching losses than previous two- or three-level VSCs. This paper presents a dc/ac/dc system using a transformer coupling two modular multilevel VSCs. In such a system, the capacitors occupy a large fraction of the volume of the cells but a significant reduction in volume can be achieved by raising the ac frequency. Using high frequency can also bring benefits to other passive components such as the transformer but also results in higher switching losses due to the higher number of waveform steps per second. This leads to a tradeoff between volume and losses which has been explored in this study and verified by simulation results with a transistor level model of 30-MW case study. The outcome of the study shows that a frequency of 350 Hz provides a significant improvement in volume but also a penalty in losses compared to 50 Hz.
Abstract 4305: Germline structural variants shape prostate cancer clinical and molecular evolution (2023)

Abstract Inherited genetic variation profoundly influences cancer risk and outcome. While the impact of germline single nucleotide polymorphisms has been well-studied in several cancer types, the effects of germline structural variants (gSVs) on cancer biology and clinical outcomes is largely unknown. From our cohort of 300 men with localized, intermediate risk prostate cancer, we identified 6,003 gSVs present in at least 3% of patients; 48 were associated with recurrent somatic alterations or clinical outcome. Of these, approximately 50% were associated with expression of nearby genes or intersected with exons or regulatory regions. Using external cohorts, we validated three gSVs that were strongly associated with poor clinical outcomes, including an inversion at chr14q24.1 present in ~20% of patients. Notably, a strong synergistic effect on outcome was observed in patients with somatic TP53 alterations or high genomic instability, defining a new aggressive prostate cancer subtype with chr14INV as a novel, recurrent biomarker. Citation Format: Nicholas K. Wang, Alexandre Rouette, Kathleen E. Houlahan, Takafumi N. Yamaguchi, Julie Livingstone, Chol-Hee Jung, Peter Georgeson, Michael Fraser, Yu-Jia Shiah, Cindy Q. Yao, Vincent Huang, Natalie S. Fox, Natalie Kurganovs, Katayoon Kasaian, Veronica Y. Sabelnykova, Jay Jayalath, Kenneth Weke, Helen Zhu, Theodorus van der Kwast, Tony Papenfuss, Housheng H. He, Niall M. Corcoran, Robert G. Bristow, Alexandre R. Zlotta, Christopher Hovens, Paul C. Boutros. Germline structural variants shape prostate cancer clinical and molecular evolution. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4305.
Patterns of relapse after immunotherapy in patients with high-risk neuroblastoma. (2022)

10043 Background: While the addition of anti-GD2 immunotherapy led to improvement in outcomes in patients on the Children’s Oncology Group (COG) ANBL0032 study, relapse remains a concern. Prior studies demonstrated the prognostic importance of time to first relapse, however, the effect of immunotherapy on timing and patterns of relapse in neuroblastoma (NBL) have yet to be evaluated. The purpose of this exploratory analysis was to describe the impact of immunotherapy on patterns of relapse in patients with high-risk NBL, including a descriptive comparison of sites of relapse based on post-consolidation treatment received [dinutuximab with cytokines and isotretinoin (DIN) vs isotretinoin alone (ISO)]. Methods: A retrospective, descriptive analysis of patients on ANBL0032 was performed, including patients randomized to DIN or ISO and those non-randomly assigned to DIN after ISO arm closure. Pt characteristics including age, stage, MYCN amplification status, tumor grade, mitosis-karyorrhexis index (MKI) and ploidy were summarized descriptively and relapse sites were tabulated. For DIN patients who subsequently relapsed, overall survival (OS) was calculated starting from the time of first relapse after enrollment on ANBL0032 (“post-relapse OS”). Kaplan-Meier OS curves were generated based on site of relapse. Results: The analytic cohort included 1,431 (DIN = 1,327; ISO = 104) patients. Among DIN patients, 492 relapsed, many in &gt; 1 site. In the randomized cohort (n = 248), 122 relapsed (DIN = 68/144; ISO = 54/104). The frequencies (DIN; ISO) by site of relapse in the randomized cohort were: bone (53%; 54%), CNS (16%; 11%), lymph node (13%; 17%), abdominal (10%; 17%), paraspinal (6%; 2%), liver (3%; 4%), other soft tissue (22%; 7%). A higher proportion of ISO patients had marrow relapse (29.4% DIN; 48.2% ISO); however, the proportion of DIN patients with lung relapses appeared higher (9% vs 2%). Among all relapsed patients, the proportion with bone relapse did not appear to differ between treatment groups, regardless of MYCN status. Among patients with MYCN amplified disease, the proportion with marrow relapse did not appear to differ based on treatment [21/149 (14.1%) DIN; 3/20 (15.0%) ISO]; however, among patients with MYCN non-amplified disease, the proportion with marrow relapse appeared higher in the ISO group [16/23; 69.6%] vs the DIN group [52/193 (26.9%)]. Conclusions: In this exploratory analysis of patients on COG ANBL0032, the pattern for site of relapse appears to differ between patients treated with DIN vs ISO. While immunotherapy remains the treatment of choice in this population, the findings from this retrospective exploratory analysis warrant further investigation to decrease the risk for post-immunotherapy relapse. Clinical trial information: NCT00026312.
Elastic damping and dynamic characteristics of vibration isolators made of wire materials of different types (2014)

A technology of manufacturing all-metal vibration insulation elastic-damping elements made of differentwire materials (Metal Rubber, MR Russia, Spring Cushion Germany) is presented in the paper. Elasticdamping,amplitude-frequency and mass-overall characteristics of three types of Russian and German vibrationinsulators are obtained and compared. On the basis of these results the main conclusions on different types ofvibration insulators are formulated and recommendations for the application of MR vibration insulators in theworld practice of vibration protection are given. The results of research and comparison of static, dynamic andmass-overall characteristics of three different types of vibration insulators are presented in the paper.