gebhart/patrepeval huggingface dataset:
Investigations of the synergy of Composite Cycle and intercooled recuperation (2018)

ABSTRACT The synergistic combination of two promising engine architectures for future aero engines is presented. The first is the Composite Cycle Engine, which introduces a piston system in the high pressure part of the core engine, to utilise closed volume combustion and high temperature capability due to instationary operation. The second is the Intercooled Recuperated engine that employs recuperators to utilise waste heat from the core engine exhaust and intercooler to improve temperature levels for recuperation and to reduce compression work. Combinations of both architectures are presented and investigated for improvement potential with respect to specific fuel consumption, engine weight and fuel burn against a turbofan. The Composite Cycle alone provides a 15.6% fuel burn reduction against a turbofan. Options for adding intercooler were screened, and a benefit of up to 1.9% fuel burn could be shown for installation in front of a piston system through a significant, efficiency-neutral weight decrease. Waste heat can be utilised by means of classic recuperation to the entire core mass flow before the combustor, or alternatively on the turbine cooling bleed or a piston engine bypass flow that is mixed again with the main flow before the combustor. As further permutation, waste heat can be recovered either after the low pressure turbine – with or without sequential combustion – or between the high pressure and low pressure turbine. Waste heat recovery after the low pressure turbine was found to be not easily feasible or tied to high fuel burn penalties due to unfavourable temperature levels, even when using sequential combustion or intercooling. Feasible temperature levels could be obtained with inter-turbine waste heat recovery but always resulted in at least 0.3% higher fuel burn compared to the non-recuperated baseline under the given assumptions. Consequently, only the application of an intercooler appears to provide a considerable benefit for the examined thermodynamic conditions in the low fidelity analyses of various engine architecture combinations with the specific heat exchanger design. Since the obtained drawbacks of some waste heat utilisation concepts are small, innovative waste heat management concepts coupled with the further extension of the design space and the inclusion of higher fidelity models may achieve a benefit and motivate future investigations.
Hesperetin induces an apoptosis-triggered extrinsic pathway and a p53- independent pathway in human lung cancer H522 cells (2017)

We studied the chemoprevention property of hesperetin on H522 cells using MTT, an apoptosis assay, an analysis of cell cycle progression, and the mitochondrial membrane potential, and apoptotic marker gene expression was determined using quantitative PCR. Hesperetin enhanced apoptotic cell death and mitochondrial membrane potential loss in H522 cells. Hesperetin up-regulated the levels of Fas, FADD, and caspase-8 expression and downregulted the levels of caspase-3 and caspase-9, p53, and Bax expression in H522 cells. This study shows that hesperetin induces apoptosis in H522 cells via a pathway independentof p53 and Bax but triggers the death-receptor Fas-initiated FADD/ caspase-8-dependent apoptotic pathway.
Tissue-engineered microvascular networks for gene therapy (2003)

The authors have explored the use of tissue-engineered microvascular networks for gene therapy. Rat microvascular endothelial cells (RMEC), engineered to secrete human growth hormone (hGH), continued to secrete hGH after forming microvascular networks in Matrigel. When hGH-releasing microvascular networks were implanted subcutaneously into nude mice the hGH concentration in serum, while decreasing initially, leveled off at /spl sim/0.2 ng/ml and remained stable for over ten months.
Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor (2015)

Abstract A practical and efficient synthesis of a complex chiral atropisomeric HIV integrase inhibitor has been accomplished. The combination of a copper‐catalyzed acylation along with the implementation of the BI‐DIME ligands for a ligand‐controlled Suzuki cross‐coupling and an unprecedented bis(trifluoromethane)sulfonamide‐catalyzed tert ‐butylation renders the synthesis of this complex molecule robust, safe, and economical. Furthermore, the overall synthesis was conducted in an asymmetric and diastereoselective fashion with respect to the imbedded atropisomer.
Eccentricity effect of a transverse magnetic dipole in a conductive borehole in a homogeneous isotropic formation (2003)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2003Eccentricity effect of a transverse magnetic dipole in a conductive borehole in a homogeneous isotropic formationAuthors: Dean M. HomanTom BarberSteve BonnerGerry MinerboDzevat OmeragicRichard RosthalDean M. HomanSchlumberger, Tom BarberSchlumberger, Steve BonnerSchlumberger, Gerry MinerboSchlumberger, Dzevat OmeragicSchlumberger, and Richard RosthalSchlumbergerhttps://doi.org/10.1190/1.1817975 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1817975FiguresReferencesRelatedDetailsCited ByInductive conductivity tensor measurement for flowline or material samplesReview of Scientific Instruments, Vol. 81, No. 7Response study of a tilted‐magnetic dipole propagation mockup tool in various formationsDean M. Homan, Gerald Minerbo, and Richard Rosthal6 October 2006Triaxial induction tool with electrode sleeve: A study of its response to borehole eccentricitySofia Davydycheva, Dean Homan, and Gerald Minerbo6 October 2006 SEG Technical Program Expanded Abstracts 2003ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2003 Pages: 2452 publication data© 2003 Copyright © 2003 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 03 Jan 2005 CITATION INFORMATION Dean M. Homan, Tom Barber, Steve Bonner, Gerry Minerbo, Dzevat Omeragic, and Richard Rosthal, (2003), "Eccentricity effect of a transverse magnetic dipole in a conductive borehole in a homogeneous isotropic formation," SEG Technical Program Expanded Abstracts : 518-521. https://doi.org/10.1190/1.1817975 Plain-Language Summary PDF DownloadLoading ...
Controlled preparation of poly(ethylene glycol) and poly(L‐lactide) block copolymers in the presence of a monomer activator (2009)

Abstract Polymerization of L ‐lactide (LA) was performed in the presence of trifluoromethanesulfonic acid (CF 3 SO 3 H) via an activated monomer mechanism to synthesize various block copolymers composed of polyethyleneglycol (PEG) and poly( L ‐lactide) (PLLA). The PLLAs obtained had molecular weights close to theoretical values calculated from LA/PEG molar ratios and exhibited monomodal GPC curves. A 1 H NMR spectroscopic study showed that the LA carbonyl carbon signal exhibited a change in chemical shift to lower field, caused by electron delocalization of the carbonyl carbon by CF 3 SO 3 H. We successfully prepared PEG and PLLA block copolymers using this activated monomer mechanism. We concluded that synthesis proceeded by LA ring‐opening polymerization caused by PEG in the presence of CF 3 SO 3 H to yield PEG and PLLA block copolymers. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 5917–5922, 2009
Correction (1991)

The sequence reported in our 22 March 1991 report "Isolation of a rel -related human cDNA that potentially encodes the 65-kD subunit of NF-κB" [ Science 251, 1490 (1991)], contained some errors. Resequencing under strong denaturing conditions revealed three insertions at nucleotide positions 1194, 1212, and 1220, which changed the AA sequence from RSAR-PRLGP to QISQASALAP (residues 372 to 380), thus accounting for some of the divergence in this region. A corrected sequence has been sent to GenBank.
A Low‐Bandgap Poly(2,7‐Carbazole) Derivative for Use in High‐Performance Solar Cells (2007)

Polymeric materials are promising for solar cell applications. High-molecular-weight and soluble poly[N-9'-heptadecanyl-2,7-carbazole-alt-5,5-(4',7'-di- 2-thienyl-2',1',3'-benzothiadiazole)] is synthesized by either a Stille or Suzuki coupling reaction. Electrochemical and optical characterization of this thermally and air-stable polymeric material is reported, and bulk heretojunction polymer/fullerene photovoltaic devices are fabricated.
Middleware scheduling optimization techniques for distributed real-time and embedded systems (2003)

Developers of mission-critical distributed real-time and embedded (DRE) systems face a fundamental tension between: (1) the performance gains achievable with hand-crafted optimizations to systems built largely from scratch and (2) the development cost and cycle-time reductions offered by common off-the-shelf (COTS) middleware. The paper describes how the Kokyu portable middleware scheduling framework, which is built using standards-based COTS middleware and OS primitives, can be used both to: (1) maintain the flexibility and reuse offered by COTS middleware, and (2) provide opportunities for domain-specific optimizations that are needed to meet stringent real-time performance requirements.
Nanoparticle delivery systems, general approaches, and their implementation in multiple myeloma (2017)

Multiple myeloma (MM) is a hematological malignancy that remains incurable, with relapse rates >90%. The main limiting factor for the effective use of chemotherapies in MM is the serious side effects caused by these drugs. The emphasis in cancer treatment has shifted from cytotoxic, non-specific chemotherapies to molecularly targeted and rationally designed therapies showing greater efficacy and fewer side effects. Traditional chemotherapy has shown several disadvantages such as lack of targeting capabilities, systemic toxicity, and side effects; low therapeutic index, as well as most anticancer drugs, has poor water solubility. Nanoparticle delivery systems (NPs) are capable of targeting large doses of chemotherapies into the target area while sparing healthy tissues, overcoming the limitations of traditional chemotherapy. Here, we review the current state of the art in nanoparticle-based strategies designed to treat MM. Many nanoparticle delivery systems have been studied for myeloma using non-targeted NPs (liposomes, polymeric NPs, and inorganic NPs), triggered NPs, as well as targeted NPs (VLA-4, ABC drug transporters, bone microenvironment targeting). The results in preclinical and clinical studies are promising; however, there remains much to be learned in the emerging field of nanomedicine in myeloma.
Quiescent phase respiratory gating for PET/CT (2009)

1473 Objectives Previous studies have shown that patients spend more time breathing near end expiration where less motion occurs and tend to return to the same end expiration location. Images extracted from this end-expiration quiescent interval are expected to yield an optimal SNR in PET/CT studies with respiratory motion. We report on the quiescent phase respiratory gating method and evaluate its performance compared to ungated and conventional phase gating images. Methods We simulated noise-free PET acquisitions of the NCAT phantom with respiratory patterns derived from 1295 patient studies. Data with a corresponding respiratory displacement signal below a certain threshold of the amplitude of each cycle were extracted to form quiescent phase images. Images generated with 4 thresholds at 10%, 20%, 30%, and 50% were compared to images gated over the entire respiratory cycle using 6 equal phases (‘fully-gated’) and ungated images. Image quality was evaluated in terms of the tumor SUVmax and fraction of counts as a surrogate for image noise. Results Tumor SUVmax decreased and the fraction of counts increased with larger thresholds. For the 20% threshold, the patients spent 40% time on average in the quiescent phase and the mean SUVmax increased 22% compared to that of the ungated images. Only 1 of the 6 fully-gated images was comparable to the quiescent phase image in terms of SUVmax but with increased noise. Patient studies are ongoing. Conclusions Compared to the ungated and fully-gated images, quiescent phase gating yields an improved SNR. There is potential for quiescent phase gating to effectively improve tumor quantification with minimal noise increase in PET/CT.
Electronic Correlation Strength of Inorganic Electrides from First Principles (2021)

Strongly correlated electron systems, generally recognized as d- and f-electron systems, have attracted attention as a platform for the emergence of exotic properties such as high-Tc superconductivity. However, correlated electron behaviors have been recently observed in a group of novel materials, electrides, in which s-electrons are confined in subnanometer-sized spaces. Here, we present a trend of electronic correlation of electrides by evaluating the electronic correlation strength obtained from model parameters characterizing effective Hamiltonians of 19 electrides from first principles. The calculated strengths vary in the order 0D ≫ 1D > 2D ∼ 3D electrides, which corresponds to experimental trends, and exceed 10 (a measure for the emergence of exotic properties) in all of the 0D and some of the 1D electrides. We also found the electronic correlation depends on the cation species surrounding the s-electrons. The results indicate that low-dimensional electrides will be new research targets for studies of strongly correlated electron systems.
Low Emittance Growth in a LEBT with Un-Neutralized Section (2018)

In a Low Energy Beam Transport line (LEBT), the emittance growth due to the beam's space charge is typically suppressed by way of neutralization from either electrons or ions, which originate from ionization of the background gas. In cases where the beam is chopped, the neutralization pattern usually changes throughout the beginning of the pulse, causing the Twiss parameters to differ significantly from their steady state values, which, in turn, may result in beam losses downstream. For a modest beam perveance, there is an alternative solution, in which the beam is kept un-neutralized in the portion of the LEBT that contains the chopper. The emittance can be nearly preserved if the transition to the un-neutralized section occurs where the beam exhibits low transverse tails. This report introduces the rationale for the proposed scheme and formulates the physical arguments for it as well as its limitations. An experimental realization of the scheme was carried out at Fermilab's PIP2IT where low beam emittance dilution was demonstrated for a 5 mA, 30 keV $H^{-}$ beam.
A MultiCenter Pilot Randomized Controlled Trial of Remote Ischemic Preconditioning in Major Vascular Surgery (2015)

A pilot randomized controlled trial that evaluated the effect of remote ischemic preconditioning (RIPC) on clinical outcomes following major vascular surgery was performed. Eligible patients were those scheduled to undergo open abdominal aortic aneurysm repair, endovascular aortic aneurysm repair, carotid endarterectomy, and lower limb revascularization procedures. Patients were randomized to RIPC or to control groups. The primary outcome was a composite clinical end point comprising any of cardiovascular death, myocardial infarction, new-onset arrhythmia, cardiac arrest, congestive cardiac failure, cerebrovascular accident, renal failure requiring renal replacement therapy, mesenteric ischemia, and urgent cardiac revascularization. Secondary outcomes were components of the primary outcome and myocardial injury as assessed by serum troponin values. The primary outcome occurred in 19 (19.2%) of 99 controls and 14 (14.1%) of 99 RIPC group patients (P = .446). There were no significant differences in secondary outcomes. Our trial generated data that will guide future trials. Further trials are urgently needed.
Experimental characterization of a two-photon memory (1997)

We demonstrate the recording of 100 planes of digital images in a page-oriented two-photon memory and characterize the images in terms of signal-to-noise ratio and bit error rate. Possible error sources in the recording are discussed, and methods for compensating for some of these effects are presented. Looking at the distributions of the normalized bit intensities, we are able to estimate the minimum achievable bit error rate for this system.
Publisher Correction: Brain charts for the human lifespan (2022)

In the version of this article initially published, there were errors in the affiliations for K. Im (missing affiliation, Division of Newborn Medicine and Neuroradiology, Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA), J. Lerch (missing affiliation, Mouse Imaging Centre, Toronto, Ontario, Canada), S. Villeneuve and X. N. Zuo (incorrect affiliation numbers listed), H. Yun (missing affiliation, Division of Newborn Medicine and Neuroradiology, Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA), and H. J. Zar (extra affiliation shown). In addition, the affiliation numbers for all authors listed in the consortium membership section were incorrect by 1–3 digits. The errors have been corrected in the HTML and PDF versions of the article.
Modelling and Handling Uncertainties in Mobile Robotics (1997)

This paper introduces a method for modelling a Mobile Robot's environment, with its in-built uncertainties, in the Configuration Space using sonar range finders. The sonar uncertainties are modelled using a possibilistic, rather than probabilistic, measure and are represented by Fuzzy Membership grades. The Resistive Grid path planning method, that maps the Fuzzy Configuration Space Map into a grid of resistors and models goals as voltage sources, is used for planning a path. The near-optimal planned path takes into consideration position and modelling uncertainties, kinematic constraints of the vehicle as well as the uncertainty of the goal. The path is produced incrementally, giving inherent interleaving between planning and execution, thus the method is particularly suited for real time applications.
Dolutegravir Plasma Concentrations According to Companion Antiretroviral Drug: Unwanted Drug Interaction or Desirable Boosting Effect? (2016)

Atazanavir coadministration significantly inhibited dolutegravir metabolism, ultimately resulting in a two- to fourfold increase in drug disposition compared with other antiretroviral drugs. This boosting effect of atazanavir could be used to optimize dolutegravir dosing in particular clinical settings.
The development of aerospace polyimide adhesives (1983)

Few materials are available which can be used as aerospace adhesives at temperatures in the range of 300 C. The Materials Division at NASA-Langley Research Center developed several high temperature polyimide adhesives to fulfill the stringent needs of current aerospace programs. These adhesives are the result of a decade of basic research studies on the structure property relationships of both linear and addition aromatic polyimides. The development of both in house and commercially available polyimides is reviewed with regards to their potential for use as aerospace adhesives.
Synergy in Nanomedicine: What It Is Not, and What It Might Be (2021)

Interactions between nanoformulations delivering two or more drugs-or a drug and some other therapeutic modality-are often described as synergistic. In fact, synergy is a specific term of art, with important therapeutic implications. The term is often misused in the nanoscience literature. Here we discuss what synergy is and an approach to demonstrating it rigorously.
Impact of cardiac resynchronization therapy on the severity of mitral regurgitation (2011)

Mitral regurgitation improvement at 3 months predicts CRT response and MR improvement at 12-month follow-up. This finding could have implications for subsequent MR surgical therapies.
Effect of various exposure histories on sorption and dilation in a family of polycarbonates (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of various exposure histories on sorption and dilation in a family of polycarbonatesD. S. Pope, G. K. Fleming, and W. J. KorosCite this: Macromolecules 1990, 23, 11, 2988–2994Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/ma00213a029https://doi.org/10.1021/ma00213a029research-articleACS PublicationsRequest reuse permissionsArticle Views108Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Semantic Understanding of General Linguistic Items by Means of Fuzzy Set Theory (2007)

Modern statistical techniques used in the field of natural language processing are limited in their applications by the fact they suffer from the loss of most of the semantic information contained in text documents. Fuzzy techniques have been proposed as a way to correct this problem through the modelling of the relationships between words while accommodating the ambiguities of natural languages. However, these techniques are currently either restricted to modelling the effects of simple words or are specialized in a single domain. In this paper, we propose a novel statistical-fuzzy methodology to represent the actions described in a variety of text documents by modelling the relationships between subject-verb-object triplets. The research will focus in the first place on the technique used to accurately extract the triplets from the text, on the necessary equations to compute the statistics of the subject-verb and verb-object pairs, and on the formulas needed to interpolate the fuzzy membership functions from these statistics and on those needed to de fuzzify the membership value of unseen triplets. Taken together, these sets of equations constitute a comprehensive system that allows the quantification and evaluation of the meaning of text documents, while being general enough to be applied to any domain. In the second phase, this paper will proceed to experimentally demonstrate the validity of our new methodology by applying it to the implementation of a fuzzy classifier conceived especially for this research. This classifier is trained using a section of the Brown Corpus, and its efficiency is tested with a corpus of 20 unseen documents drawn from three different domains. The positive results obtained from these experimental tests confirm the soundness of our new approach and show that it is a promising avenue of research.