gebhart/patrepeval huggingface dataset:
[Arthroscopic debridement of full-thickness tears of the rotator cuff: a retrospective multicenter study of 283 cases with 3-year follow-up]. (2000)

The purpose of this study was to assess clinical and radiological course of full-thickness rotator cuff tears treated by arthroscopic debridement and to discuss surgical indications according to patient demands and anatomical lesions.This retrospective and multicentric study included patients with a minimal 3 years follow-up. The coronal extent of the supraspinatus tear was described as distal, intermediate or retracted. The sagittal extent to the infraspinatus and/or subscapularis and rotator interval was detailed. All patients were evaluated pre and post-operatively using Constant score and radiological A-P view for sub-acromial space measurement. In order to assess the influence of age, anatomical extent of the tear and follow-up, results were analyzed for 4 groups of patients according to their age: group I (19 cases less than 50 years), group II (88 cases from 51 to 60 years), group III (58 cases from 61 to 65 years) and group IV (118 cases over 65 years). Results were finally evaluated according the arthroscopic procedure (isolated acromioplasty and biceps tenotomy, or association of both).283 patients, aged 63.1 years (range 32 to 82) entered this study. A complete antero-posterior tear of the supra-spinatus tendon was noticed in 93.2 p. 100 of cases. The tear extended to the infraspinatus tendon in 57.3 p. 100, and to the subscapularis tendon in 29 p. 100 of cases. The long head of the biceps was involved in 73 p. 100 of cases. 218 acromioplasties and 116 biceps tenotomies were performed. The 2 procedures were combined in nearly 25 p. 100 of cases. At final revision (mean follow-up of 4.7 years), 98 patients (34.6 p. 100) were very satisfied, 122 (43.1 p. 100) satisfied, 43 (15.2 p. 100) moderatly satisfied and 20 (7.1 p. 100) were disappointed. The average Constant score increased from 42.4 to 67.6 points. The radiological study showed a 1 mm narrowing of the sub-acromial space. Objective results were surprisingly good for group I at a 5.4 years follow-up but dropped from group II to group IV, mainly in relation with the extent of the tear. A deleterious effect of the isolated biceps tenotomy was demonstrated in case of subacromial space superior to 7 mm. Inversely after this procedure patients with a narrowed space improved.Even if traditional bias of retrospective and mullticentric study could not be avoided, the large number of patients and long follow-up of this study are superior to most of the published papers. The extent of the supraspinatus tear seems to progress during the 50-60 years decade. Objective results appeared to be much more related to the anatomical lesions than to the arthroscopic procedure.This series did not demonstrate a secondary clinical or radiological deterioration after an endoscopic treatment without repair of full-tickness rotator cuff tears. Subacromial decompression and/or biceps tenotomy indications depend on age and extension of the tear.
402: Comparison of the Safety and Efficacy of Three Gas-Driven Ultrathin 17-Gauge Cryoneedles with Varying Iceball Geometries in a Live Laparoscopic-Assisted Percutaneous Renal Cryoablation Porcine Model (2006)

defined, serum-free medium (AIM-V), however, IL-4 inhibited the TNF-a induced proliferation of RCC. IL-4 and TN F-a synergistically induced apoptosis of RCC as well as a complex cytokine response by RCC, which included the synergistic upregulation of RANTES and MCP-1 CONCLUSIONS: IL-4 alone has little effect on the spontaneous proliferation of RCC but can prevent the enhancement of proliferation induced by growth promoters like FBS and TNF-a. The concomitant growth inhibitory, apoptosis-inducing and cytokine enhancing effects of IL-4 in combination with TN F-a on RCC support the view that Th2 cytokines may be required for productive immune responses against RCC.
Room-temperature-deposited dielectrics and superconductors for integrated photonics (2017)

We present an approach to fabrication and packaging of integrated photonic devices that utilizes waveguide and detector layers deposited at near-ambient temperature. All lithography is performed with a 365 nm i-line stepper, facilitating low cost and high scalability. We have shown low-loss SiN waveguides, high-Q ring resonators, critically coupled ring resonators, 50/50 beam splitters, Mach-Zehnder interferometers (MZIs) and a process-agnostic fiber packaging scheme. We have further explored the utility of this process for applications in nonlinear optics and quantum photonics. We demonstrate spectral tailoring and octave-spanning supercontinuum generation as well as the integration of superconducting nanowire single photon detectors with MZIs and channel-dropping filters. The packaging approach is suitable for operation up to 160 <sup>°</sup>C as well as below 1 K. The process is well suited for augmentation of existing foundry capabilities or as a stand-alone process.
Extremely Nondegenerate 2-Photon Processes for Detection and Gain (2014)

We observe large enhancement of nondegenerate two-photon absorption compared to the degenerate case. We use this to sensitively detect and image mid-IR light with simple uncooled photodiodes. The enhancement also applies to 2-photon emission and gain.
Dual application of duckweed and azolla plants for wastewater treatment and renewable fuels and petrochemicals production (2014)

Differences in absorption rates of the key wastewater nutrients, ammonium and phosphorus by different aquatic macrophytes can be used for optimization of composition of wastewater effluents. The generated data suggest that the composition of the petrochemicals can be modified in a targeted fashion, not only by using different species, but also by changing the source plants' metabolic profile, by exposing them to different abiotic or biotic stresses. This study presents an attractive, ecologically friendly and cost-effective solution for efficient bio-filtration of swine wastewater and petrochemicals production from generated biomass.
The iCoCooN: Integration of Cobweb Charts with Parallel Coordinates for Visual Analysis of DCE-MRI Modeling Variations (2014)

Efficacy of radiotherapy treatment depends on the specific characteristics of tumorous tissues. For the determination of these characteristics, clinical practice uses Dynamic Contrast Enhanced (DCE) Magnetic Resonance Imaging (MRI). DCE-MRI data is acquired and modeled using pharmacokinetic modeling, to derive per voxel a set of parameters, indicative of tissue properties. Different pharmacokinetic modeling approaches make different assumptions, resulting in parameters with different distributions. A priori, it is not known whether there are significant differences between modeling assumptions and which assumption is best to apply. Therefore, clinical researchers need to know at least how different choices in modeling affect the resulting pharmacokinetic parameters and also where parameter variations appear. In this paper, we introduce iCoCooN: a visualization application for the exploration and analysis of model-induced variations in pharmacokinetic parameters.We designed a visual representation, the Cocoon, by integrating perpendicularly Parallel Coordinate Plots (PCPs) with Cobweb Charts (CCs). PCPs display the variations in each parameter between modeling choices, while CCs present the relations in a whole parameter set for each modeling choice. The Cocoon is equipped with interactive features to support the exploration of all data aspects in a single combined view. Additionally, interactive brushing allows to link the observations from the Cocoon to the anatomy. We conducted evaluations with experts and also general users. The clinical experts judged that the Cocoon in combination with its features facilitates the exploration of all significant information and, especially, enables them to find anatomical correspondences. The results of the evaluation with general users indicate that the Cocoon produces more accurate results compared to independent multiples.
Modelling of a polarization-division multiplexing soliton transmission system (1998)

We have simulated numerically a polarization-division multiplexing soliton transmission system by using propagation equations with and without the third-order dispersion and Raman shift terms, respectively. It is found that the Raman shift terms can reduce the soliton interactions and hence the allowed transmission distance increases.
Limb-Girdle Muscular Dystrophy is Closely Linked to the Fibrillin Locus on Chromosome 15 (1993)

Limb-girdle Muscular Dystrophy (LGMD) is a rare form of muscular dystrophy inherited as an autosomal recessive trait. The LGMD locus was recently mapped to chromosome 15. We tested the hypothesis that fibrillin is a candidate in the etiology of the disorder by genetic linkage analysis. A large Amish kindred segregating the disorder was genotyped for two markers specific for the fibrillin gene on chromosome 15. A total of 105 individuals were genotyped and a maximum LOD score of Z = 9. 135 at theta = 0.04 was obtained. Our results confirmed the mapping of the LGMD on chromosome 15 and excluded fibrillin as a candidate molecule. These data will be useful in the construction of a fine map of the region surrounding the LGMD locus, a prerequisite for the cloning of the LGMD gene.
Analysis of the eddy-current field of a rotary bias field device for magneto-optic recording (1998)

A method is presented for predicting the eddy current field of a rotary bias field device for magneto-optic recording. The method entails a simulation of the device dynamics and an evaluation of a semi-analytical expression for the eddy current field. The theory is demonstrated via application to a practical bias field device.
Neutrophils promote T-cell activation through the regulated release of CD44-bound Galectin-9 from the cell surface during HIV infection (2021)

The interaction of neutrophils with T cells has been the subject of debate and controversies. Previous studies have suggested that neutrophils may suppress or activate T cells. Despite these studies, the interaction between neutrophils and T cells has remained a largely unexplored field. Here, based on our RNA sequencing (RNA-seq) analysis, we found that neutrophils have differential transcriptional and functional profiling depending on the CD4 T-cell count of the HIV-infected individual. In particular, we identified that neutrophils in healthy individuals express surface Galectin-9 (Gal-9), which is down-regulated upon activation, and is consistently down-regulated in HIV-infected individuals. However, down-regulation of Gal-9 was associated with CD4 T-cell count of patients. Unstimulated neutrophils express high levels of surface Gal-9 that is bound to CD44, and, upon stimulation, neutrophils depalmitoylate CD44 and induce its movement out of the lipid raft. This process causes the release of Gal-9 from the surface of neutrophils. In addition, we found that neutrophil-derived exogenous Gal-9 binds to cell surface CD44 on T cells, which promotes LCK activation and subsequently enhances T-cell activation. Furthermore, this process was regulated by glycolysis and can be inhibited by interleukin (IL)-10. Together, our data reveal a novel mechanism of Gal-9 shedding from the surface of neutrophils. This could explain elevated plasma Gal-9 levels in HIV-infected individuals as an underlying mechanism of the well-characterized chronic immune activation in HIV infection. This study provides a novel role for the Gal-9 shedding from neutrophils. We anticipate that our results will spark renewed investigation into the role of neutrophils in T-cell activation in other acute and chronic conditions, as well as improved strategies for modulating Gal-9 shedding.
Human herpesvirus 6B origin: sequence diversity, requirement for two binding sites for origin-binding protein, and enhanced replication from origin multimers (1994)

A previously identified human herpesvirus 6B (HHV-6B) origin of DNA replication contains two binding sites for the origin-binding protein (OBPH6B). We have investigated the functional significance of these sites by determining the replication efficiencies of mutated origin sequences, using a transient replication assay. The results indicate that both sites are required for DNA replication. In addition, we have tested the functional consequences of linear sequence amplifications in the origin. The data show that tandemized origin elements are more efficiently replicated than single-copy origins. Finally, we have determined the extent of interstrain origin sequence variation that exists among HHV-6 isolates by cloning, sequencing, and analyzing origins from a number of virus isolates, including examples of both HHV-6A and HHV-6B.
Supplementary Figure S8 from Blocking Angiopoietin-2 Promotes Vascular Damage and Growth Inhibition in Mouse Tumors Treated with Small Doses of Radiation (2023)

&lt;p&gt;Supplementary Figure S8&lt;/p&gt;
Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer (2016)

Targeting epigenetic pathways is a promising approach for cancer therapy. Here, we report on the unexpected finding that targeting calcium signaling can reverse epigenetic silencing of tumor suppressor genes (TSG). In a screen for drugs that reactivate silenced gene expression in colon cancer cells, we found three classical epigenetic targeted drugs (DNA methylation and histone deacetylase inhibitors) and 11 other drugs that induced methylated and silenced CpG island promoters driving a reporter gene (GFP) as well as endogenous TSGs in multiple cancer cell lines. These newly identified drugs, most prominently cardiac glycosides, did not change DNA methylation locally or histone modifications globally. Instead, all 11 drugs altered calcium signaling and triggered calcium-calmodulin kinase (CamK) activity, leading to MeCP2 nuclear exclusion. Blocking CamK activity abolished gene reactivation and cancer cell killing by these drugs, showing that triggering calcium fluxes is an essential component of their epigenetic mechanism of action. Our data identify calcium signaling as a new pathway that can be targeted to reactivate TSGs in cancer.
ChemInform Abstract: New Perfluoroalkylated Phosphocholines. Effect on Particle Size and Stability of Fluorocarbon Emulsions. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Electronic and vibronic properties of Mg-doped GaN: The influence of etching and annealing (2002)

We report a systematic study of the effects of wet chemical treatment, inductively coupled plasma etching, and thermal annealing on the surface and optical properties of Mg-doped p-type GaN. The chemical bonding and surface stoichiometry of the GaN surface subjected to different processing steps are analyzed based on the results of x-ray photoelectron spectroscopy. Atomic force microscopy has been employed to characterize the surface morphology. Photoluminescence (PL) and micro-Raman techniques have been used to investigate the electronic and vibrational properties of plasma etched surface. We have correlated the surface changes induced by dry etching of p-type GaN to the corresponding changes in the defect and impurity related states, through their manifestation in the PL spectra. We have observed several local vibrational modes (LVMs) in p-type GaN subjected to various processing steps. A broad structure in the low-temperature Raman spectra around 865 cm−1 is attributed to the electronic Raman scattering from neutral Mg acceptors. In addition to the LVMs of Mg–Hn complexes, two new modes near 2405 and 2584 cm−1 are observed from the etched p-GaN surface. We have also carried out PL and micro-Raman analyses of Mg-doped GaN films annealed under different conditions.
The Reaction of [(1-Azaazulen-2-yl)imino]phosphorane with Arylaldehydes: Formation of Bis[(1-azaazulen-2-yl)amino]arylmethanes (2010)

Reaction of [(3-ethoxycarbonyl-1-azaazulen-2-yl)imino]triphenylphosphorane with arylaldehydes gave bis[(3-ethoxycarbonyl-1-azaazulen-2-yl)amino]arylmethanes via corresponding azaazulenylimine intermediacy.][3][4][5][6][7][8][9][10] Generally, a simple aza-Wittig reaction with aldehydes proceeds to give the corresponding imines.In the azaazulene chemistry, aza-Wittig reactions have been also used for synthesis of azaazulene fused heterocycles. 8,11It is thought that azulenylimines and azaazulenylimines would be good precursors for constructing azaazulene fused heterocycles, but the synthesis of azulenylimines and azaazulenylimines from azulenylamines and azaazulenylamines have not been reported.Only few reports, where the reaction of [(1-azaazulen-8-yl)imino]phosphorane (1) with arylaldehydes gave 2 12 (Scheme 1) and [(azulen-2-yl)imino]phosphorane (3) with aldehydes (4) gave 5 13 (Scheme 2), showed the possibility of the formations of azulenylimine and azaazulenylimines as intermediacy.Therefore, we investigated the synthesis of (1-azaazulen-2-yl)imines by the reaction of [(1-azaazulen-2-yl)imino]phosphorane with
Probing Life Limiting Parasitic Reactions: A Conceptual Model for Long Term Impedance Rise (2015)

The detailed understanding of non-Faradaic parasitic reactions which diminish battery calendar life is essential to the development of effective batteries for use in long life applications. The dissolution of cathode materials including manganese, cobalt and vanadium oxides in battery systems has been identified as a battery failure mechanism, yet detailed dissolution studies including kinetic analysis are absent from the literature. The results presented provide a framework for the quantitative and kinetic analyses of the dissolution of cathode materials which will aid the broader community in more fully understanding this battery failure mechanism. In this study, a series of vanadium oxide and phosphate based cathode materials are studied relative to their dissolution in battery electrolyte. Kinetic analysis of the results provides a quantitative framework for rationalizing the impact of structure and composition on dissolution. Further, the result of cathode solubility at the systems level is investigated shedding light on the interaction of the negative electrode with the dissolved transition metal species. The findings are used to provide a conceptual model for the resultant impedance rise.
Cellular Target Genes of Epstein-Barr Virus Nuclear Antigen 2 (2006)

Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) is a key determinant in the EBV-driven B-cell growth transformation process. By activating an array of viral and cellular target genes, EBNA-2 initiates a cascade of events which ultimately cause cell cycle entry and the proliferation of the infected B cell. In order to identify cellular target genes that respond to EBNA-2 in the absence of other viral factors, we have performed a comprehensive search for EBNA-2 target genes in two EBV-negative B-cell lines. This screen identified 311 EBNA-2-induced and 239 EBNA-2-repressed genes that were significantly regulated in either one or both cell lines. The activation of most of these genes had not previously been attributed to EBNA-2 function and will be relevant for the identification of EBNA-2-specific contributions to EBV-associated malignancies. The diverse spectrum of EBNA-2 target genes described in this study reflects the broad spectrum of EBNA-2 functions involved in virus-host interactions, including cell signaling molecules, adapters, genes involved in cell cycle regulation, and chemokines.
Validation of Diagnostic Support Tool of Lumbar Spinal Canal Stenosis for Osteoarthritis of the Hip (2010)

日本脊椎脊髄病学会より腰部脊柱管狭窄の早期診断を目的として腰部脊柱管狭窄診断サポートツールが作成された．チェック項目には下肢症状などを含むため，変形性股関節症などの下肢疾患も腰部脊柱管狭窄疑いとして検出されることが危惧される．人工股関節全置換術を行った変形性股関節症169例（男：女＝28：141，平均年齢64（43-89）歳）を対象に腰部脊柱管狭窄診断サポートツールにて調査し，腰部脊柱管狭窄疑いと検出される頻度（検出率）を求め，腰部脊柱管狭窄診断サポートツールの妥当性を検証した．病歴と問診の項目のみでは検出率は39％であったが，身体所見を加味すると33％となった．病歴と問診の項目での検出率の高さは，両疾患の患者背景や自覚症状の類似性を反映し，身体所見（理学所見）による検出率の低下は腰部脊柱管狭窄診断サポートツールの身体所見の項目が股関節疾患との鑑別に有用であることを示唆している．
Carbohydrate structure of hamster plasma fibronectin. Evidence for chemical diversity between cellular and plasma fibronectins. (1982)

The structure of the carbohydrate moiety of hamster plasma fibronectin was determined. The glycopeptides and oligosaccharides released by hydrazinolysis (Fukuda, M., Kondo, T., and Osawa, T. (1976) J. Biochem. (Tokyo) 80, 1223-1232) were analyzed by methylation and exoglycosidase digestion and the major oligosaccharide unit of hamster plasma fibronectin was shown to be (formula, see text) The structure of carbohydrate moiety of plasma fibronectin shown above (NeuGly, N-glycolyl-neuraminic acid) and that of cellular fibronectin (Fukuda, M., and Hakomori, S. (1979) J. Biol. Chem. 254, 5451-5457) are distinctly different with respect to the linkage of sialic acid, the degree of sialylation and the absence or presence of fucose. These results, therefore, provide the evidence for chemical diversity between cellular (fibroblast) and plasma fibronectins.
Novel Nanoscopic Architectures. Linear-Globular ABA Copolymers with Polyether Dendrimers as A Blocks and Polystyrene as B Block (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel Nanoscopic Architectures. Linear-Globular ABA Copolymers with Polyether Dendrimers as A Blocks and Polystyrene as B BlockIvan Gitsov and Jean M. J. FrechetCite this: Macromolecules 1994, 27, 25, 7309–7315Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/ma00103a012https://doi.org/10.1021/ma00103a012research-articleACS PublicationsRequest reuse permissionsArticle Views351Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis of chitosan-coated polyoxometalate nanoparticles against cancer and its metastasis (2015)

HeLa cells, before and after treatment with nanoparticles.
An Evaluation of Non-Stochastic Lattice Structures Fabricated Via Electron Beam Melting (2006)

Metal foam structures have many applications and can be used as structural supports, heat exchangers, shock absorbers, and implant materials. Stochastic metal foams having different cell sizes and densities have been commercially available for a number of years. This paper addresses a different type of foams which are known as non-stochastic foams, or lattice structures. These foams have a well defined repeating unit cell structure rather than the random cell structure in commercially available stochastic foams. The paper reports on preliminary research on the fabrication of non-stochastic Ti-6Al-4V alloy foams using the Electron Beam Melting process. Behavior of the structures in compression, bending, and low cycle repeating load tests are discussed, and recommendations about cell geometry and processing conditions are made.