gebhart/patrepeval huggingface dataset:
Activity of fractionated radioimmunotherapy with clivatuzumab tetraxetan combined with low-dose gemcitabine (Gem) in advanced pancreatic cancer (APC). (2011)

240 Background: The 90 Y-labeled anti-mucin humanized mAb, clivatuzumab tetraxetan ( 90 Y-hPAM4), is in clinical development in APC. A phase I/II trial of 90 Y-hPAM4 with low-dose radiosensitizing Gem has now concluded 90 Y-dose escalation. Methods: Pts with untreated, inoperable, stage 3-4 APC received 200 mg/m 2 Gem once-weekly x 4 with 90 Y-hPAM4 on wks 2-4, and with 90 Y escalated in cohorts by 3+3 design. Tumor responses were assessed by CT, FDG/PET and serum CA19.9, with cycles repeated until progression or unacceptable toxicity. Results: Of 42 pts (40-87 yrs, ECOG PS 0-1, 36 stage 4), 4 withdrew early while 38 received weekly x 3 90 Y doses of 6.5 (N=4), 9 (N=12), 12 (N=17) and 15 (N=5) mCi/m 2 . Treatment was well-tolerated with few non-hematologic side-effects, including 13 pts retreated with 1-3 additional cycles. CTCv3 grade 3-4 plts or ANC developed in 21/38 (55%) pts after cycle 1 and all (100%) retreated pts after last cycle. Escalation reached limits on radiation doses to the marrow, but hematologic suppression was reversible without major infections or bleeding events, except for 3 pts after repeated cycles, one with extensive marrow tumor infiltration. By CT, the overall disease control rate was 55%, including 6 pts (16%) with partial responses (PRs) by RECIST criteria and 15 pts (39%) with stabilization as best response. After cycle 1, 43% (10/23) improved by PET studies (negative or &gt;25% reduced uptake), and 36% (9/25) with elevated CA19.9 levels had &gt;50 decreases. With 26% (10/38) of pts still in follow-up, 55% (21/38) have now achieved survival of ≥ 6 months [18% (7/38) ≥ 1 yr]. Treatment outcome may increase with 90 Y dose, since pts treated at 3 x ≥12 mCi/m 2 vs ≤9 mCi/m 2 had 19% vs 6% PRs by CT, 47% vs 22% CA19.9 decreases, 63% vs 25% PET improvement, and 64% vs. 44% survival ≥ 6 months. Anecdotally, PS and pain level improved, which needs validation. Updated survival will be presented at the meeting. Conclusions: Fractionated 90 Y-hPAM4 plus low-dose Gem showed encouraging therapeutic activity with manageable hematological toxicity. The 12-mCi/m 2 dose level was selected for continued dose exploration now underway, involving standard Gem doses and adding maintenance Gem. [Table: see text]
A Rodent Model of Traumatic Stress Induces Lasting Sleep and Quantitative Electroencephalographic Disturbances (2015)

Hyperarousal and sleep disturbances are common, debilitating symptoms of post-traumatic stress disorder (PTSD). PTSD patients also exhibit abnormalities in quantitative electroencephalography (qEEG) power spectra during wake as well as rapid eye movement (REM) and non-REM (NREM) sleep. Selective serotonin reuptake inhibitors (SSRIs), the first-line pharmacological treatment for PTSD, provide modest remediation of the hyperarousal symptoms in PTSD patients, but have little to no effect on the sleep-wake architecture deficits. Development of novel therapeutics for these sleep-wake architecture deficits is limited by a lack of relevant animal models. Thus, the present study investigated whether single prolonged stress (SPS), a rodent model of traumatic stress, induces PTSD-like sleep-wake and qEEG spectral power abnormalities that correlate with changes in central serotonin (5-HT) and neuropeptide Y (NPY) signaling in rats. Rats were implanted with telemetric recording devices to continuously measure EEG before and after SPS treatment. A second cohort of rats was used to measure SPS-induced changes in plasma corticosterone, 5-HT utilization, and NPY expression in brain regions that comprise the neural fear circuitry. SPS caused sustained dysregulation of NREM and REM sleep, accompanied by state-dependent alterations in qEEG power spectra indicative of cortical hyperarousal. These changes corresponded with acute induction of the corticosterone receptor co-chaperone FK506-binding protein 51 and delayed reductions in 5-HT utilization and NPY expression in the amygdala. SPS represents a preclinical model of PTSD-related sleep-wake and qEEG disturbances with underlying alterations in neurotransmitter systems known to modulate both sleep-wake architecture and the neural fear circuitry.
Accelerating Seismic Imaging Using Novel Boundary Condition Handling (2012)

In this paper, we present a load balancing method that attempts to avoid typical load balancing problems by removing the need for absorbing boundary condition calculations. We accomplish this by introducing an invertible, nonlinear transformation that maps the entire infinite model space into a finite space. This transform creates a finite halo of points around the modeling area of interest that models the infinite region of space beyond the limits of the model. The nonlinearity results in a slowing of wave propagation in the halo region and thereby provides a buffer zone that shields the model from unphysical reflections. Since the calculation is the same at every point of the model, load balancing is guaranteed.
A Consensus-State-Aware Adaptive Algorithm for Tuning CSMA Parameters in Multi-Agent Networks (2019)

Reaching consensus to realize a group objective is one of the fundamental problems for collaborative control of multi-agent networks, over which the convergence speed is a momentous performance index. However, in many multi-agent networks that using CSMA/CA mechanism, it is difficult to reach consensus quickly when there are tremendous devices to send packets in the network under communication constraints, due to the decline of communication reliability caused by the channel competition mechanism. This paper proposes a distributed adaptive parameters tuning algorithm for CSMA/CA mechanism, which can make the state of all devices in a common multi- agent network converge to an identical value as soon as possible with less energy consumption, especially in the situation where the channel competition is fiercer. The algorithm is light-weight and has lower complexity without any modification to existing communication protocols. Simulation results demonstrate the excellent superiority of the algorithm in convergence speed and energy consumption.
Function and Regulation of Resistance Genes in Ketolide producing Bacteria (2015)

Antibiotics-producing bacteria need resistance genes to avoid suicide. Streptomyces venezuelae produces two related ketolide antibiotics, methymycin (MTM) and pikromycin (PKM), which target the ribosome. Two putative resistance genes, pikR1 and pikR2 are associated with the ketolide biosynthetic gene cluster. These genes encode enzymes homologous to Erm rRNA methyltransferases that are known to modify A2058 in 23S rRNA within the macrolide-binding site. We investigated why the producer would carry two similar resistance genes. Expression of PikR1 and PikR2 in E. coli conferred resistance to macrolides suggesting that these rRNA methylases target a nucleotide within macrolide binding site. Primer extension and mass spectrometry analyses showed that PikR1 and PikR2 monomethylated and dimethylated A2058 in 23S rRNA, respectively. Both pikR genes are preceded by short leader peptides – a feature often associated with inducible resistance. In vivo reporters showed that the expression of pikR2, but not of pikR1, was induced by MTM and PKM. The pikR2 induction is mediated by programmed translation arrest. Our results suggest that the producer ribosomes are constitutively monomethylated at A2058 by the action of PikR1 to provide the basal level of protection. Upon the activation of antibiotics production, the expression of dimethylase PikR2 is activated leading to a higher degree of resistance. Potentially, both of these genes could be a source of clinically relevant resistance to ketolide antibiotics.
Zinc Oxide Nanorod‐Based Piezoelectric Dermal Patch for Wound Healing (2016)

Current treatments for wound healing engage in passive healing processes and rarely participate in stimulating skin cell behaviors for active wound healing. Electric potential difference‐derived electrical fields (EFs) are known to modulate skin cell behaviors. Here, a piezoelectric dermal patch is developed that can be applied on skin wound site and EF is generated to promote wound healing. The one‐directionally aligned zinc oxide nanorod‐based piezoelectric patch generates piezoelectric potential upon mechanical deformations induced by animal motion, and induces EF at the wound bed. In vitro and in vivo data demonstrate that the piezoelectric patch promotes the wound healing process through enhanced cellular metabolism, migration, and protein synthesis. This modality may lead to a clinically relevant piezoelectric dermal patch therapy for active wound healing.
Retinal microvascular abnormalities and cognitive decline (2009)

Signs of retinal vascular changes, as markers of the cerebral microvasculature, are associated with declines in executive function and psychomotor speed, adding to the growing evidence for the role of microvascular disease in cognitive decline in the elderly.
Acetylation of Vertebrate H2A.Z and Its Effect on the Structure of the Nucleosome (2009)

Purified histone H2A.Z from chicken erythrocytes and a sodium butyrate-treated chicken erythroleukemic cell line was used as a model system to identify the acetylation sites (K4, K7, K11, K13, and K15) and quantify their distribution in this vertebrate histone variant. To understand the role played by acetylation in the modulation of the H2A.Z nucleosome core particle (NCP) stability and conformation, an extensive analysis was conducted on NCPs reconstituted from acetylated forms of histones, including H2A.Z and recombinant H2A.Z (K/Q) acetylation mimic mutants. Although the overall global acetylation of core histones destabilizes the NCP, we found that H2A.Z stabilizes the NCP regardless of its state of acetylation. Interestingly and quite unexpectedly, we found that the change in NCP conformation induced by global histone acetylation is dependent on H2A/H2A.Z acetylation. This suggests that acetylated H2A variants act synergistically with the acetylated forms of the core histone complement to alter the particle conformation. Furthermore, the simultaneous occurrence of H2A.Z and H2A in heteromorphic NCPs that most likely occurs in vivo slightly destabilizes the NCP, but only in the presence of acetylation.
Medical case-based retrieval by leveraging medical ontology and physician feedback: UIUC-IBM at ImageCLEF 2010 (2010)

This paper reports the experiment results of the UIUC-IBM team in participating in the medical case retrieval task of ImageCLEF 2010. We experimented with multiple methods to leverage medical ontology and user (physician) feedback; both have worked very well, achieving the best retrieval performance among all the submissions.
Cyclin dependent Kinase-5 is a negative Regulator of the MAP kinase pathway (2000)

Conference Abstract| October 01 2000 Cyclin dependent Kinase-5 is a negative Regulator of the MAP kinase pathway P. Veeranna Sharma; P. Veeranna Sharma 1Laboratory of Neurochemistry, Laboratory of Neurobiology, NINDS, Gene Targetting Facility, NICDR, National Institutes of Health, Bethesda, MD 20892, USANIH, Bethesda Search for other works by this author on: This Site PubMed Google Scholar M. Sharma; M. Sharma 1Laboratory of Neurochemistry, Laboratory of Neurobiology, NINDS, Gene Targetting Facility, NICDR, National Institutes of Health, Bethesda, MD 20892, USANIH, Bethesda Search for other works by this author on: This Site PubMed Google Scholar R. K. Sihag; R. K. Sihag 1Laboratory of Neurochemistry, Laboratory of Neurobiology, NINDS, Gene Targetting Facility, NICDR, National Institutes of Health, Bethesda, MD 20892, USANIH, Bethesda Search for other works by this author on: This Site PubMed Google Scholar N. Amin; N. Amin 1Laboratory of Neurochemistry, Laboratory of Neurobiology, NINDS, Gene Targetting Facility, NICDR, National Institutes of Health, Bethesda, MD 20892, USANIH, Bethesda Search for other works by this author on: This Site PubMed Google Scholar A. B. Kulkarni; A. B. Kulkarni 1Laboratory of Neurochemistry, Laboratory of Neurobiology, NINDS, Gene Targetting Facility, NICDR, National Institutes of Health, Bethesda, MD 20892, USANIH, Bethesda Search for other works by this author on: This Site PubMed Google Scholar P. Grant; P. Grant 1Laboratory of Neurochemistry, Laboratory of Neurobiology, NINDS, Gene Targetting Facility, NICDR, National Institutes of Health, Bethesda, MD 20892, USANIH, Bethesda Search for other works by this author on: This Site PubMed Google Scholar H. C. Pant H. C. Pant 1Laboratory of Neurochemistry, Laboratory of Neurobiology, NINDS, Gene Targetting Facility, NICDR, National Institutes of Health, Bethesda, MD 20892, USANIH, Bethesda Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (5): A433. https://doi.org/10.1042/bst028a433 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation P. Veeranna Sharma, M. Sharma, R. K. Sihag, N. Amin, A. B. Kulkarni, P. Grant, H. C. Pant; Cyclin dependent Kinase-5 is a negative Regulator of the MAP kinase pathway. Biochem Soc Trans 1 October 2000; 28 (5): A433. doi: https://doi.org/10.1042/bst028a433 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
Discovery of losartan, the first angiotensin II receptor antagonist. (1995)

The 'discovery' of losartan represents three separate discoveries: (1) losartan as the unique biphenyltetrazole molecule and the first of a new chemical class; (2) losartan as a tool to identify AT1-subtype receptors; and (3) losartan as a specific probe for exploring the multiple roles of angiotensin II (Ang II) in normal physiology and pathologic states. Losartan is the first nonpeptide orally active Ang II receptor antagonist to reach clinical trials. Losartan was selected for its affinity for Ang II receptors, functional antagonism of Ang II, lack of agonist properties, and oral anti-hypertensive effects. Losartan has been widely used to define the distribution and function of AT receptor subtypes. Although possible roles of the AT2 subtype have been reported, virtually all of the known effects of Ang II are blocked by losartan. Specific AT1 receptor blockade has been broadly compared with ACE inhibition. Possible differences on the basis of AT1 selectivity, bradykinin potentiating effects and Ang II formed by non-ACE pathways are discussed. Losartan blocks the vascular constrictor effect of Ang II, the Ang II-induced aldosterone synthesis and/or release, and the Ang II-induced cardiovascular 'growth' in vitro and in vivo. In various models of experimental hypertension, losartan prevents or reverses the elevated blood pressure and the associated cardiovascular hypertrophy similar to ACE inhibitors. Likewise, in models of renal failure (for example reduced renal mass, puromycin, ochratoxin), losartan, like ACE inhibition, markedly reduced the elevation in blood pressure, proteinuria or sclerosis. In aortocaval shunt, coronary ligation and ventricular pacing models of heart failure, losartan demonstrated a pathological role for Ang II by reversing the associated haemodynamic findings. In SHR-stroke prone, losartan dramatically increased survival while having a limited effect on blood pressure, suggesting a non-pressure dependent effect of Ang II. These collective data show that Ang II exerts complex pathological effects in experimental models of vascular, cardiac, renal and cerebral disease. The effectiveness of losartan in experimental models of heart failure supports its evaluation in clinical trials with patients with heart failure.
Synthesis of High Molecular Weight Polycarbonate by Solid-State Polymerization (2001)

The solid-state polymerization (SSP) of small particles (20 μm) of poly(bisphenol A carbonate) resulted in high molecular weight material (Mw of 36 000 g/mol). Molecular weight distribution broadening was not observed in polycarbonate in the form of small granulated powders but did occur in large polycarbonate beads (3.6 mm diameter). We hypothesize that this broadening is due to slow diffusion of phenol inside the larger polymer particles. A systematic investigation of the role of CO2 pressure and temperature was performed. It was found that the increase in molecular weight was a strong function of CO2 pressure and temperature. Additionally, the chain extension reactions occurred faster at higher supercritical CO2 flow rates. The SSP of polycarbonate in the presence of supercritical CO2 can be accomplished at temperatures as low as 90 °C, which is 60 °C lower than the Tg of polycarbonate at normal conditions. This should suppress the side reactions that lead to color body formation, thereby resulting in a product with good optical clarity and color.
Construction of the System to Detect and Control Damages in CFRP Laminates Using Small-Diameter FBG Sensors and SMA Actuators (2003)

In this research, a small-diameter fiber Bragg grating (FBG) senor and a shape memory alloy (SMA) foil were embedded into carbon fiber reinforced plastics (CFRP) cross-ply laminates. Since the form of reflection spectrum from the FBG sensor was very sensitive to non-uniform strain distribution, the occurrence of transverse cracks in the laminates could be detected by the FBG sensor. On the other hand, when the pre-strained SMA foil is heated, shape memory effect produces compressive stress (recovery stress). Thus the occurrence and progress of damages in the laminates could be suppressed by the SMA actuator. This suppression effect was also confirmed by the FBG sensor.
Improvement of characteristics of leaky surface acoustic wave on LiTaO3 (2013)

Abstract Leaky surface acoustic wave (LSAW) devices on Al‐electrode/36–48° YX‐LiTaO 3 substrates have seen wide use as filters and duplexers in cell phones because they possess a suitable electromechanical coupling factor and reflection coefficient, and a good Q factor for cell phones. In this paper, a new LSAW structure consisting of upper Al electrodes stacked on lower grooved Cu electrodes in LiTaO 3 is proposed and compared with Al electrodes (0.1 λ )/42° YX‐LiTaO 3 , which have been considered the best structure. We have been able to improve the characteristics of the LSAW. © 2013 Wiley Periodicals, Inc. Electron Comm Jpn, 96(2): 25–31, 2013; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.10409
250 MHz digital FIR filters for PRML disk read channels (2002)

Digital FIR filters are key components of state-of-the-art partial-response signaling maximum-likelihood detection (PRML) read/write channel ICs but consume significant circuit area and power. These 10-tap and 8-tap, 6b filters provide PR-IV channel equalization at 20+MB/s data rates. Achieving these data rates while reducing power and area requires an optimized distributed arithmetic (DA) architecture combined with custom circuit design and layout. These filters improve attainable data rate by a factor of about 1.5 and power and area consumption by a factor of two, compared with standard-cell-designed filters using the same architecture and technology.
Orbital Mixer: Using Atomic Orbital Features for Basis Dependent Prediction of Molecular Wavefunctions (2022)

Leveraging ab initio data at scale has enabled the development of machine learning models capable of extremely accurate and fast molecular property prediction. A central paradigm of many previous works focuses on generating predictions for only a fixed set of properties. Recent lines of research instead aim to explicitly learn the electronic structure via molecular wavefunctions from which other quantum chemical properties can directly be derived. While previous methods generate predictions as a function of only the atomic configuration, in this work we present an alternate approach that directly purposes basis dependent information to predict molecular electronic structure. The backbone of our model, Orbital Mixer, uses MLP Mixer layers within a simple, intuitive, and scalable architecture and achieves competitive Hamiltonian and molecular orbital energy and coefficient prediction accuracies compared to the state-of-the-art.
IoTSuite: a framework to design, implement, and deploy IoT applications: demonstration abstract (2016)

Internet of Things (IoT) application development is technically challenging and complex due to several factors such as the presence of different IoT protocols, interoperability issues, lack of industry standards and dealing with the heterogeneity that exists both in Physical and Internet worlds. Furthermore, developers involved in the IoT application development have to address issues pertaining to different life-cycles ranging from design, implementation to deployment (deployment complexities due to the possibilities of wide range of devices). Manual effort involved in all above three phases for heterogeneous devices is a time-consuming and error-prone process. We demonstrate IoTSuite which is an application development platform consisting of a suite of tools motivated by the need to simplify IoT application development. The IoTSuite supports several features such as automatic code generation and integration with a set of modeling languages. It takes high-level specification as input that abstract heterogeneity related complexity. It integrates compiler and deployment module to provide automation at different phases of application development process.
Synthesis and Conformational Properties of the M(4-6)(5-7) Bicyclic Tetrapeptide Common to the Vancomycin Antibiotics (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSynthesis and Conformational Properties of the M(4-6)(5-7) Bicyclic Tetrapeptide Common to the Vancomycin AntibioticsDavid A. Evans, Christopher J. Dinsmore, Andrew M. Ratz, Deborah A. Evrard, and James C. BarrowView Author Information Department of Chemistry and Chemical Biology Harvard University, Cambridge, Massachusetts 02138 Cite this: J. Am. Chem. Soc. 1997, 119, 14, 3417–3418Publication Date (Web):April 9, 1997Publication History Received27 December 1996Published online9 April 1997Published inissue 1 April 1997https://pubs.acs.org/doi/10.1021/ja964419uhttps://doi.org/10.1021/ja964419urapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1051Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amides,Aromatic compounds,Chemical synthesis,Monomers,Peptides and proteins Get e-Alerts