gebhart/patrepeval huggingface dataset:
Measurement-Based Validation of Z3RO Precoder to Prevent Nonlinear Amplifier Distortion in Massive MIMO Systems (2022)

In multiple input multiple output (MIMO) systems, precoding allows the base station to spatially focus and multiplex signals towards each user. However, distortion introduced by power amplifier nonlinearities coherently combines in the same spatial directions when using a conventional precoder such as maximum ratio transmission (MRT). This can strongly limit the user performance and moreover create unauthorized out-of-band (OOB) emissions. In order to overcome this problem, the zero third-order distortion (Z3RO) precoder was recently introduced. This precoder constraints the third-order distortion at the user location to be zero. In this work, the performance of the Z3RO precoder is validated based on real-world channel measurement data. The results illustrate the reduction in distortion power at the UE locations: an average distortion reduction of 6.03 dB in the worst-case single-user scenario and 3.54 dB in the 2-user case at a back-off rate of -3dB.
Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19 (2021)

The introduction of vaccines has inspired new hope in the battle against SARS-CoV-2. However, the emergence of viral variants, in the absence of potent antivirals, has left the world struggling with the uncertain nature of this disease. Antibodies currently represent the strongest correlate of immunity against COVID-19, thus we profiled the earliest humoral signatures in a large cohort of severe and asymptomatic COVID-19 individuals. While a SARS-CoV-2-specific immune response evolved rapidly in survivors of COVID-19, non-survivors exhibited blunted and delayed humoral immune evolution, particularly with respect to S2-specific antibody evolution. Given the conservation of S2 across β-coronaviruses, we found the early development of SARS-CoV-2-specific immunity occurred in tandem with pre-existing common β-coronavirus OC43 humoral immunity in survivors, which was selectively also expanded in individuals that develop paucisymptomatic infection. These data point to the importance of cross-coronavirus immunity as a correlate of protection against COVID-19.
Biphasic cultivation strategy to avoid Epo-Fc aggregation and optimize protein expression (2016)

In biphasic cultivations, the culture conditions are initially kept at an optimum for rapid cell growth and biomass accumulation. In the second phase, the culture is shifted to conditions ensuring maximum specific protein production and the protein quality required. The influence of specific culture parameters is cell line dependent and their impact on product quality needs to be investigated. In this study, a biphasic cultivation strategy for a Chinese hamster ovary (CHO) cell line expressing an erythropoietin fusion protein (Epo-Fc) was developed. Cultures were run in batch mode and after an initial growth phase, cultivation temperature and pH were shifted. Applying a DoE (Design of Experiments) approach, a fractional factorial design was used to systematically evaluate the influence of cultivation temperature and pH as well as their synergistic effect on cell growth as well as on recombinant protein production and aggregation. All three responses were influenced by the cultivation temperature. Additionally, an interaction between pH and temperature was found to be related to protein aggregation. Compared with the initial standard conditions of 37°C and pH 7.05, a parameter shift to low temperature and acidic pH resulted in a decrease in the aggregate fraction from 75% to less than 1%. Furthermore, the synergistic effect of temperature and pH substantially lowered the cell-specific rates of glucose and glutamine consumption as well as lactate and ammonium production. The optimized culture conditions also led to an increase of the cell-specific rates of recombinant Epo-Fc production, thus resulting in a more economic bioprocess.
Reliability of Postural Sway Measures of Standing Balance Tasks (2018)

The reliability of balance exercises performance in experimental and clinical studies has typically been confined to a small set of exercises. In order to advance the field of assessing balance exercise intensity, establishing the reliability of performance during a more diverse array of exercises should be undertaken. The purpose of this study was to investigate the test-retest reliability of postural sway produced during performance of 24 different balance tasks, and to evaluate the reliability of different measures of postural sway. Sixty-two healthy subjects between the ages of 18 and 85 years of age (50% female, mean age 55 ± 20 years) participated. Subjects were tested during two visits one week apart and performed two sets of the 24 randomized standing tasks per visit. The tasks consisted of combinations of the following factors: surface (firm and foam), vision (eyes open and eyes closed), stance (feet apart and semi-tandem), and head movement (no movement, yaw, and pitch). Angular position displacement, angular velocity, and linear acceleration postural sway in the pitch and roll planes was recorded via an inertial measurement unit. The postural sway measures demonstrated at fair to good test-retest reliability with few exceptions, and angular velocity measures demonstrated the greatest reliability. The between-visit reliability of two averaged trials was excellent for most tasks. The study indicates that performance of most balance tasks used as part of balance rehabilitation is reliable, and quantitative assessment could be used to document change.
Are C-Reactive Protein Associated Genetic Variants Associated with Serum Levels and Retinal Markers of Microvascular Pathology in Asian Populations from Singapore? (2013)

Common variants associated with serum CRP, first detected in primarily European studies, are also associated with CRP levels in East-Asian and South-Asian populations. We did not find a causal link between CRP and retinal measures of microvascular disease.
Yb:Lasers for high repetition rate VUV ultrafast chemistry (2016)

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Fabrication and Analysis of a Novel 3 DOF Parallel Wrist Mechanism (1995)

This paper describes a three-degrees-of-freedom parallel-actuated wrist mechanism developed at Ohio University. This mechanism is capable of pointing an axis within a cone from the nominal position. The mechanism allows unlimited rotation about the pointing axis. Experiments were conducted to validate the kinematic model of the designed wrist.
Dielectric properties of new LTCC material applied to high frequencies (2014)

We have developed an LTCC (Low Temperature Co-fired Ceramics) material, which consists of Mg2SiO4, SrTiO3 and highly crystallized Li–Mg–Zn–B–Si–O glass. The material was able to be co-fired with inner cupper electrodes that have high electric conductivity. The dielectric constant is 8.8 and its Q value is 1620 at 25 GHz. Moreover, its temperature coefficient of dielectric constant τε is +16 ppm/°C, which is much smaller than that of the LTCC material reported previously. Using the new LTCC material, band-pass filter (BPF) was successfully fabricated. The BPF had no defects such as delamination or cracks, and its filter properties were confirmed.
A Multi-Time Scale Co-Optimization Method for Sizing of Energy Storage and Fast-Ramping Generation (2016)

Power systems need to have sufficient generation capacity to support the demand at all times. In addition, dispatchable generation resources should be capable of adjusting their power output on a short term basis not only to alleviate uncertainties of nondispatchable generation and load fluctuations but also to correct for forecast errors. This paper presents a long-term planning approach to co-optimize capacities of energy storages and fast-ramping generation. We model and integrate the capability of the storage to provide multiple services for the system. Our formulation takes into account wind generation and demand forecast errors as well as short-term fluctuations. A stochastic optimization problem is formulated consisting of hourly and intrahour time scales. The approach determines the optimal size of newly deployed generation and storage resources to provide adequate generation capacity and ramping needed to support hourly demand. Additionally, our method ensures that the system is capable of following the net load in intrahour time intervals, as well as mitigating the impact of short-term wind power and load fluctuations. In this formulation, power balance, network security, and system ramping capability are stochastic constraints being modeled as chance constraints. A 3-bus and the IEEE 24-bus test systems are studied to show the effectiveness of the proposed approach.
Electric Field Enhanced Plasmid Delivery to Liver Hepatocellular Carcinomas (2002)

Electric field enhanced molecular delivery for cancer research and treatment is a new technology that has demonstrated its effectiveness in clinical trials using bleomycin or cisplatin (Heller, R., Gilbert, R., Jaroszeski, M. J. Clinical applications of electrochemotherapy, Advanced Drug Delivery Reviews 35,119-129, 1999), as chemotherapeutic agents. The technology is being investigated in research applications for applicability as a method to enhance gene expression in a target tumor. Success is predicated on an appropriate effective electric field mediated delivery protocol that triggers significant appropriate gene expression duration and levels. An electric field mediated delivery protocol includes a set of conditions associated with the electric field, the electroporation signature, as well as parameters associated with the plasmid and the electric field applicator. Manipulation of the electrical parameters within the electroporation signature generates different gene expression levels in liver hepatocellular carcinomas. Statistically significant gene expression levels were obtained that differed by an order of magnitude when two different electric field strength and duration conditions were employed.
Depth-enhanced fluorescence imaging using masked detection of structured illumination (2014)

There is a growing interest in imaging fluorescence contrast at depth within living tissues over wide fields of view and in real time. Most methods used to date to improve depth detection of fluorescence information involve acquisition of multiple images, postprocessing of the data using a light propagation model, and are capable of providing either depth-sectioned or tomographic fluorescence information. We introduce a method, termed masked detection of structured illumination, that allows the enhancement of fluorescence imaging at depth without postprocessing. This method relies on the scanning of a collimated beam onto a turbid medium and the physical masking of the point spread function on the detection arm before acquisition on a CCD camera. By preferentially collecting diffuse photons at a chosen source-detector range, this method enhances fluorescence information at depth and has the potential to form images without postprocessing and in real time.
Phosphatases and Kinases (1987)

The reaction conditions and applications of two phosphatases and one kinase are described in this unit. Bacterial alkaline phosphatase (BAP) from E. coli and calf intestine phosphatase (CIP) from veal are commonly used in nucleic acid research. Both enzymes catalyze the hydrolysis of 5'-phosphate residues from DNA, RNA, and ribo- and deoxyribonucleoside triphosphates. The dephosphorylated products possess 5'-hydroxyl termini which can subsequently be radioactively labeled using [gamma-32P]ATP and T4 polynucleotide kinase. T4 polynucleotide kinase has 3 activities: the forward reaction efficiently catalyzes the transfer of the terminal (gamma) phosphate of ATP to the 5'-hydroxyl termini of DNA and RNA. The exchange reaction catalyzes the exchange of 5'-terminal phosphates. Lastly, T4 polynucleotide kinase is a 3' phosphatase.
ChemInform Abstract: Novel Synthesis of Substituted Chloro‐3(2H)‐pyridazinones from Pentane‐ 2,3,4‐trione 3‐Arylhydrazones. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Used of the Internet in Procurement: An Empirical Analysis (2000)

According to a recent survey, 16% of all Swiss companies use an e-commerce solution to sell their products [15]. On the other hand, most companies in Switzerland are unfamiliar with the use of the Internet for purchasing and procurement processes and especially for online buying. This paper discusses the new requirements for procurement and shows the new concepts and strategies that have recently been developed. The main focus is on the opportunities and benefits of new information and communication technologies, especially the Internet. Included in this study are the results of an empirical survey conducted in Switzerland in October 1999. The aim of the survey was to analyze to what extent the Internet is being used in procurement of Swiss companies with more than 100 employees. The results show that the take-up of the opportunities and benefits of the Internet is currently rather low and that most Swiss companies seem to be satisfied with the efficiency of their procurement processes.
Nondestructive 3D imaging of femtosecond laser written buried structures using optical coherence microscopy (2008)

We have demonstrated nondestructive 3D imaging of the femtosecond laser written 3D structures of both index change and optical breakdown within fused silica by using the optical coherence microscopy providing high lateral and depth resolution.
Supplementary Figure 5 from TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia (2023)

&lt;p&gt;PDF file - 273K, Confirmation of CD3 expression on OP9 DL1 outgrowth cells.&lt;/p&gt;
Supplementary Figure 3 from An Oncogenic Role for <i>ETV1</i> in Melanoma (2023)

Supplementary Figure 3 from An Oncogenic Role for &lt;i&gt;ETV1&lt;/i&gt; in Melanoma
IRRADIATION GROWTH OF EBR-II FUEL PINS. (1971)

Preferred orientation studies of centrifugally bonded EBR-II fuel pins showed that the pins have a [110], [001] axial texture, which is responsible for their shortening in length and diametrical growth during irradiation.The growth indices calculated from texture data correlate well with observed irradiation growth and give a single crystal growth rate, g, of 200% per % burnup, which is in the range measured for other uranium alloys.Texture gradient studies showed that the texture forms during centrifugal bonding as a stress-relieving mechanism for the y~ transformation.
Size changes associated with metal adsorption onto modified bone gelatin beads (1991)

Significant quantities of heavy metals will adsorb onto modified bone gelatin beads. As this adsorption occurs, the bead can undergo a substantial volume change. Research has shown that the equilibrium bead diameter was a function of the solution pH and the ion concentration in the solution. Here, we demonstrate that under certain conditions, the volume of the beads that absorbed the metal was only 35% of the bead volume when no metal was adsorbed. By taking advantages of these size changes, a fluidized-bed separator can be operated such that natural segregation of loaded beads occurs. This phenomenon may facilitate the design of continous separators for the recovery and concentration of heavy-metal-contaminated waters. These concepts are demonstrated using Cu(2+) adsorption onto such beads.
ChemInform Abstract: Synthetic Anthracyclines: Regiospecific Total Synthesis of D‐Ring Thiophene Analogues of Daunomycin. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
sTable 1, sTable 2, sTable 3, sFigure 1, sFigure 2, sFigure 3, sFigure 4 from The Safety of Bridging Radiation with Anti-BCMA CAR T-Cell Therapy for Multiple Myeloma (2023)

&lt;p&gt;sTable 1 shows radiation characteristics of Group A, B, and C. sTable 2 shows characteristics of CART-BCMA cells during manufacturing and at peak expansion in vivo in Group A, B, and C. sTable 3 shows details of radiation received after CART-BCMA therapy. sFigure 1 shows soluble BCMA serum levels before cyclophosphamide lymphodepletion on Day -3. sFigure 2 shows that prior radiation exposure is not associated with the level of CART-BCMA cells in vivo at peak expansion. sFigure 3 shows radiation was not associated with the level of persistent CART-BCMA cells in peripheral blood at Day 28. sFigure 4 shows level of CART-BCMA cells at peak expansion and Day 28 correlated with clinical response, and within responders, receipt of prior radiation was not associated with differences in CART=BCMA levels.&lt;/p&gt;
Neoadjuvant chemoradiotherapy to convert borderline-resectable, locally-advanced esophageal carcinoma to resectable disease. (2016)

e15500 Background: The treatment of T3-4/N+ esophageal cancer is challenging, outcomes are suboptimal and a conclusive management pattern is not well defined for borderline-resectable esophageal cancer (BREC). We present our retrospective institutional experience using preoperative chemoradiotherapy (CRT) to enable resection of BREC. Methods: We identified 67 patients with T3-4/N+ BREC who were treated with concurrent CRT between 2009 and 2014. Survival statistics were calculated with Kaplan-Meier curves and cohort comparisons were made with log-rank test and Cox regression. Results: We treated 67 patients (81% males, median age 61 years, and KPS of 80), primarily with T3N2 disease at high risk of R1 resection. Median follow up was 11 months. The most common CRT regimen was 58.8Gy in 28 fractions with carboplatin and paclitaxel. Median survival was 16.3 months. Factors predictive of overall survival (OS) on univariate analysis included age, KPS, tumor length, and surgical resection (all p < .01). Only KPS and surgery remained significant on multivariate analysis (both p < .05). Forty four (65.7%) patients without progressive disease underwent minimally invasive Ivor-Lewis esophagectomy within 100 days of CRT. Patients undergoing surgery had a median survival was 30.6 vs. 6.4 months without surgery (p < .01). Pathologic complete response rate was 27.3% and pN0 was 59.1%. The number of lymph nodes positive at surgery predicted for OS and progression-free survival (PFS) (p < .01) and was the only predictor of survival on multivariate analysis (HR 1.123 [95%CI 1.034-1.219] p = .006). Median survival for pN0 was 58.8 vs. 11.2 months for pN+ (p < .001) Acute grade 3+ toxicity was seen in 31.3% and late grade 3+ toxicity, in 43.3%. Three patients (4.5%) died during CRT or before surgery and one (2.3%) within 30 days of resection. Conclusions: Preoperative CRT enabled a significant proportion of patients with borderline-resectable disease to proceed with a potentially curative resection. Further investigation with careful patient selection is warranted in incorporating a trimodality strategy to optimize outcomes and better define a treatment algorithm for this complex cohort of patients.
Response of α2-Macroglobulin Messenger Ribonucleic Acid Expression to Acute Inflammation in the Testis is Different from the Response in the Liver and Brain1 (1994)

Recent studies from this laboratory have shown that Sertoli cells derived from 20-day-old rats and cultured in vitro synthesize and secrete a nonspecific protease inhibitor that is structurally and immunologically similar to serum α2-macroglobulin (α2-MG). In contrast to its serum homologue, the testicular α2-MG is not an acute-phase protein in the rat since its protein concentration in the rete-testis fluid does not increase in response to inflammation. In the present study we examined the expression of α2-MG mRNA in the rat testis in comparison to that in the brain and liver following induced inflammation. α2-MG mRNA in the testis did not respond to induced inflammation, whereas its protein concentration in serum and its mRNA level in the brain and liver increased significantly in 20-day-old inflamed rats. In 8-day-old rat testis, where the blood-testis barrier is not yet formed, α2-MG mRNA expression also did not respond to induced inflammation. The mRNA expression of clusterin, another authentic Sertoli cell protein whose secretion appears to be closely related to cell-cell interactions in the seminiferous epithelium, was shown to be unaffected by induced inflammation in the testis, brain, and liver. In view of the unexpected differential expression of α2-MG mRNA to induced inflammation in the testis and liver, we sought to examine whether Sertoli cell α2-MG would respond to FSH and testosterone (T), the major regulators of testicular function. Interestingly, expression of α2-MG and clusterin mRNA in the Sertoli cell was not regulated by FSH, T, or a combination of FSH and T. Since there is an intimate morphological relationship between Sertoli cells and germ cells, we next examined the effect of germ cell-conditioned medium (GCCM) on Sertoli cell α2-MG and clusterin mRNA expression. It was noted that GCCM caused a dose-dependent stimulation of α2-MG and inhibition of clusterin mRNA expression in Sertoli cells, respectively. Therefore, our studies have shown that the regulatory mechanism that modulates the expression of α2-MG mRNA in the rat testis is different from its counterpart in the brain and liver.
Rationally designed oral vaccines can set an evolutionary trap for Salmonella Typhimurium (2019)

Secretory antibody responses (Immunoglobulin A, IgA) against repetitive bacterial surface glycans, such as O-antigens and capsules, can protect against intestinal pathogenic Enterobacteriaceae . However, efficacy of such immune responses has been limited by rapid glycan evolution and phase-variation. Here, we track IgA-driven O-antigen variation in Salmonella Typhimurium, and use this to assemble an oligovalent oral vaccine which sets an evolutionary trap. IgA targeting all fitness-neutral O-antigen escape variants of Salmonella Typhimurium rapidly selected for mutants with very short O-antigen: a phenotype known to display major fitness costs and virulence attenuation in naive hosts. Evolutionary trap vaccination therefore represents an alternative concept in vaccine design. This approach capitalizes on the inevitable and rapid evolution of bacteria in the gut, and can combine protection of the individual with elimination of virulent enteropathogen reservoirs.
Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies (2022)

In this paper, we discuss the overarching framework for SeroNet epidemiology studies, critical research questions under investigation, and data accessibility for the worldwide scientific community. Lessons learned will help inform preparedness and responsiveness to future emerging diseases.