gebhart/patrepeval huggingface dataset:
Thermal Conductivity of Hydrocarbon Liquid Organic Hydrogen Carrier Systems: Measurement and Prediction (2020)

In this study, the thermal conductivity of diphenylmethane, benzyltoluene, and dibenzyltoluene and their fully hydrogenated counterparts relevant in the context of the liquid organic hydrogen carrier (LOHC) technology was investigated. For the determination of the thermal conductivity between 298.15 and 323.15 K at atmospheric pressure with an expanded uncertainty of 5% (k = 2), a steady-state guarded parallel-plate instrument was used. To discuss the thermal conductivity over a broader temperature range, measurements were also performed for the density of the pure LOHCs and binary mixtures of diphenylmethane and dicyclohexylmethane between 293.15 and 363.15 K by vibrating tube densimetry as well as for the thermal diffusivity and the Fick diffusion coefficient of binary mixtures of diphenylmethane or dicyclohexylmethane with dissolved hydrogen between 323 and 573 K and pressures between 2.7 and 6.2 MPa by dynamic light scattering (DLS). In general, the measured thermal conductivities of the compounds under investigation decrease with increasing temperature and molar mass and with the degree of hydrogenation. For mixtures of diphenylmethane and dicyclohexylmethane, the concentration dependency of the thermal conductivity shows a distinct nonideal behavior. Based on the measured thermal conductivities of the present pure substances and reference data from the literature for selected cyclic hydrocarbons, a prediction method for the thermal conductivity of such systems could be developed, which requires the molar mass and density as sole input parameters. This correlation represents the thermal conductivity of the selected dehydrogenated and hydrogenated substances and of the studied binary mixture between 298 K and their normal boiling temperature, typically within 5%. By comparison with the thermal conductivity data for diphenylmethane and dicyclohexylmethane deduced from the measurement results for thermal diffusivity and density and from literature data for the specific heat, it was found that the prediction method also allows for a reliable estimation of the thermal conductivity of LOHCs up to a temperature of 573 K, which is the relevant temperature range for hydrogen release from the hydrogenated LOHC compounds.
Dietary d ‐Psicose Reduced Visceral Fat Mass in High‐Fat Diet‐Induced Obese Rats (2012)

We can develop D-psicose as a sugar substitute and food ingredient since it can prevent obesity in normal people, but also suppress adiposity as a sugar substitute or food ingredients with antiobesity effect in obese people. D-psicose can be unique functional sweetener because of its function of reducing visceral fat mass and weight gain.
Liquid Solid Diffusion (LSD) bonding: A novel joining technology (2017)

Liquid Solid Diffusion (LSD) bonding is a novel joining technology forming solid and liquid two-phase field joints from simple binary systems. LSD creates joints that are applicable at temperatures above the melting temperature of the material composition of the initial bond. Liquid and solid inter-diffusion transform the joint composition and microstructure. The final joint is characterized by incongruent re-melting forming a coherent continuous porous solid solution phase with liquefied pores. This article briefly describes the methodology and presents experimental results based on the Au-Ge system. High quality joints were created. The effective melting point was increased by more than 200 °C above the initial eutectic melting point of the system.
Suppression of Non-reciprocal Interference in Adaptive MIMO-OFDM Cellular Systems (2005)

In a time-division-duplex system the channel state information can be obtained at the transmitter side due to channel reciprocity and it can be used to increase the spectral efficiency of a multiple-input multiple-output (MIMO) system. However, the interference structure between transmission directions does not necessarily correlate. The transmission parameters assigned based on the reverse link measurements may lead to excessively high frame error rates, if the interference structure between transmission directions differs significantly. In this paper, the performance of an adaptive MIMO-OFDM cellular system is studied in the presence of non-reciprocal multi-cell interference when the downlink interference structure is known at the receiver and/or also known at (reported to) the transmitter. The impact of realistic interference non-reciprocity scenarios for continuous real-time services is studied. Linear minimum mean squared error (MMSE) filter is applied at the receiver to suppress the impact of structured inter-cell interference, together with a simple and bandwidth efficient closed-loop compensation algorithm. Both link and system level simulation results show that the performance gain from interference suppression in the receiver is high, especially at low signal-to-interference-plus-noise ratio (SINR) region (close to the cell edge). The proposed MMSE receiver combined with simple scalar power offset feedback to the transmitter results in nearly the same performance as the case where the interference structure per sub-carrier is perfectly known at the transmitter.
Supplementary Table 2 from Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity (2023)

&lt;p&gt;PDF file - 58KB, Relative expression levels of primary human miR-9 transcripts in normal brain and glioma cells.&lt;/p&gt;
Data from Getting Knit-PI3Ky: PIK3CA Mutation Status to Direct Multimodality Therapy? (2023)

&lt;div&gt;Abstract&lt;p&gt;There is high morbidity associated with local recurrence of rectal cancer. However, the adjuvant therapies given to prevent such recurrences also have significant side effects and associated risks. The ability to select patients with the highest risk of recurrence and greatest therapeutic response will improve rectal cancer care. (Clin Cancer Res 2009;15(22):674850)&lt;/p&gt;&lt;/div&gt;
Orderings based on dissection (2017)

Abstract We continue our discussion on orderings based on a global as opposed to a local approach. In this chapter, we study methods based on dissection. We discuss different ways of obtaining and refining a dissection ordering and compare the resulting ordering with that obtained by the minimum degree ordering. We also consider the extension of these methods to unsymmetric matrices.
HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma (2020)

Asthma resistance to glucocorticoid treatment is a major health problem with unclear etiology. Glucocorticoids inhibit adrenal androgen production. However, androgens have potential benefits in asthma. <i>HSD3B1</i> encodes for 3β-hydroxysteroid dehydrogenase-1 (3β-HSD1), which catalyzes peripheral conversion from adrenal dehydroepiandrosterone (DHEA) to potent androgens and has a germline missense-encoding polymorphism. The adrenal restrictive <i>HSD3B1</i>(1245A) allele limits conversion, whereas the adrenal permissive <i>HSD3B1</i>(1245C) allele increases DHEA metabolism to potent androgens. In the Severe Asthma Research Program (SARP) III cohort, we determined the association between DHEA-sulfate and percentage predicted forced expiratory volume in 1 s (FEV<sub>1</sub>PP). <i>HSD3B1</i>(1245) genotypes were assessed, and association between adrenal restrictive and adrenal permissive alleles and FEV<sub>1</sub>PP in patients with (GC) and without (noGC) daily oral glucocorticoid treatment was determined (<i>n</i> = 318). Validation was performed in a second cohort (SARP I&II; <i>n</i> = 184). DHEA-sulfate is associated with FEV<sub>1</sub>PP and is suppressed with GC treatment. GC patients homozygous for the adrenal restrictive genotype have lower FEV<sub>1</sub>PP compared with noGC patients (54.3% vs. 75.1%; <i>P</i> < 0.001). In patients with the homozygous adrenal permissive genotype, there was no FEV<sub>1</sub>PP difference in GC vs. noGC patients (73.4% vs. 78.9%; <i>P</i> = 0.39). Results were independently confirmed: FEV<sub>1</sub>PP for homozygous adrenal restrictive genotype in GC vs. noGC is 49.8 vs. 63.4 (<i>P</i> < 0.001), and for homozygous adrenal permissive genotype, it is 66.7 vs. 67.7 (<i>P</i> = 0.92). The adrenal restrictive <i>HSD3B1</i>(1245) genotype is associated with GC resistance. This effect appears to be driven by GC suppression of 3β-HSD1 substrate. Our results suggest opportunities for prediction of GC resistance and pharmacologic intervention.
β Integrin Tyrosine Phosphorylation Is a Conserved Mechanism for Regulating Talin-induced Integrin Activation (2009)

Integrins are large membrane-spanning receptors fundamental to cell adhesion and migration. Integrin adhesiveness for the extracellular matrix is activated by the cytoskeletal protein talin via direct binding of its phosphotyrosine-binding-like F3 domain to the cytoplasmic tail of the beta integrin subunit. The phosphotyrosine-binding domain of the signaling protein Dok1, on the other hand, has an inactivating effect on integrins, a phenomenon that is modulated by integrin tyrosine phosphorylation. Using full-length tyrosine-phosphorylated (15)N-labeled beta3, beta1A, and beta7 integrin tails and an NMR-based protein-protein interaction assay, we show that talin1 binds to the NPXY motif and the membrane-proximal portion of beta3, beta1A, and beta7 tails, and that the affinity of this interaction is decreased by integrin tyrosine phosphorylation. Dok1 only interacts weakly with unphosphorylated tails, but its affinity is greatly increased by integrin tyrosine phosphorylation. The Dok1 interaction remains restricted to the integrin NPXY region, thus phosphorylation inhibits integrin activation by increasing the affinity of beta integrin tails for a talin competitor that does not form activating membrane-proximal interactions with the integrin. Key residues governing these specificities were identified by detailed structural analysis, and talin1 was engineered to bind preferentially to phosphorylated integrins by introducing the mutation D372R. As predicted, this mutation affects talin1 localization in live cells in an integrin phosphorylation-specific manner. Together, these results indicate that tyrosine phosphorylation is a common mechanism for regulating integrin activation, despite subtle differences in how these integrins interact with their binding proteins.
Gold adatoms and dimers on relaxed graphite surfaces (2004)

The interaction of deposited gold adatoms and dimers with multilayer relaxed graphite surfaces is investigated through a density functional approach with numerical orbitals and a relativistic core pseudopotential. The energy landscape for a gold adatom along [110] agrees with scanning tunneling microscopy observations including the preferred \ensuremath{\beta} binding site for adatoms and the mobility difference between silver and gold adatoms. Deposited particles are shown to induce surface deformation and polarization. Static relaxation and dynamic simulations indicate that the energetically preferred binding orientation for a gold dimer is normal rather than parallel to the graphite surface. The dimer response to a simulated scanning tunneling microscopy tip is investigated by molecular dynamics simulations.
LED packaging by ink‐jet microdeposition of high‐viscosity resin and phosphor dispersion (2008)

Abstract— An ink‐jet‐printing method applied to the microdeposition of high‐viscosity resin, including optimization of phosphor dispersion for light‐emitting‐diode (LED) packaging was examined for the first time. An ultrasonic ink‐jet‐printing method was used, in which ink droplets are ejected by a focused ultrasonic beam from a nozzle‐less printhead. To fabricate white LEDs, high‐viscosity phosphor‐dispersed resin was deposited to form an encapsulant dome. Two types of methods to control phosphor sedimentation for color uniformity were examined; one is heating the lead frame during the resin deposition, and the other is hydrophobic surface treatment of the lead frame base enabling the fabrication of a small encapsulant dome. For light direction control, a silicone micro lens was deposited on an encapsulant dome using the ink‐jet method. The results show that ultrasonic ink‐jet printing is an applicable technique to optimize and modify on‐demand optical characteristics of LED devices.
31.1: Invited Paper : Programmable Electrostatic Surface for Tactile Perceptions (2012)

Abstract We describe a fully programmable Electrostatic Tactile (ET) feedback system that delivers a range of tactile textures to a mobile display. The ET system is a robust, thin, and optically transparent structure that can be overlaid unobtrusively on top of a display screen. The system exploits the phenomenon of electrovibration to create a controllable frictional force between a user's fingertip and the surface. The system enables the realization of localized tactile information delivered to the user's skin directly, without moving parts. A tactile image is formed in accordance with the visual information displayed (virtual textures, tactile silhouettes, etc.). The magnitude and pattern of the frictional force on the display can be programmed to correspond to the images shown on the display and actual coordinates of the touch interaction in real time. This has been achieved using a variety of different materials, including those that are compatible with flexible devices.
Membrane of Functionalized Reduced Graphene Oxide Nanoplates with Angstrom-Level Channels (2016)

Membranes with atomic level pores or constrictions are valuable for separation and catalysis. We report a graphene-based membrane with an interlayer spacing of 3.7 angstrom (Å). When graphene oxide nanoplates are functionalized and then reduced, the laminated reduced graphene oxide (rGO) nanoplates or functionalized rGO membrane is little affected by an intercalated fluid, and the interlayer spacing of 3.7 Å increases only to 4.4 Å in wetted state, in contrast to the graphene oxide (GO) membrane whose interlayer spacing increases from 9 Å to 13 Å in wetted state. When applied to ion separation, this membrane reduced the permeation rate of small ions such as K(+) and Na(+) by three orders of magnitude compared to the GO membrane.
Self-applied ear-EEG for sleep monitoring at home (2022)

High quality sleep monitoring is done using EEG electrodes placed on the skin. This has traditionally required assistance by an expert when the equipment needed to mounted. However, this creates a limitation in how cheap and easy it can be to record sleep in the subject's own home. Here we present a data set of 120 home recordings of sleep, in which subjects use self-applied ear-EEG monitoring equipment. We compare this data set to a previously recorded data set with both ear-EEG and polysomnography, which was applied by an expert. Clinical relevance - On all tested metrics, self applied sleep recordings behaved the same as expert applied. This indicates that ear-EEG can reliably be used as a home sleep monitor, even when subjects apply the equipment themselves.
Transfer learning of an in vivo- derived senescence signature identifies conserved and tissue-specific senescence across species and diverse pathologies (2022)

Abstract Senescent cells (SnCs) contribute to normal tissue development and repair but accumulate with aging where they are implicated in a number of pathologies and diseases. Despite their pathological role and therapeutic interest, SnC phenotype and function in vivo remains unclear due to the challenges in identifying and isolating these rare cells. Here, we developed an in vivo -derived senescence gene expression signature using a model of the foreign body response (FBR) fibrosis in a p16 Ink4a - reporter mouse, a cell cycle inhibitor commonly used to identify SnCs. We identified stromal cells (CD45 - CD31 - CD29 + ) as the primary p16 Ink4a expressing cell type in the FBR and collected the cells to produce a SnC transcriptomic signature with bulk RNA sequencing. To computationally identify SnCs in bulk and single-cell data sets across species and tissues, we used this signature with transfer learning to generate a SnC signature score (SenSig). We found senescent pericyte and cartilage-like fibroblasts in newly collected single cell RNAseq (scRNASeq) data sets of murine and human FBR suggesting populations associated with angiogenesis and secretion of fibrotic extracellular matrix, respectively. Application of the senescence signature to human scRNAseq data sets from idiopathic pulmonary fibrosis (IPF) and the basal cell carcinoma microenvironment identified both conserved and tissue-specific SnC phenotypes, including epithelial-derived basaloid and endothelial cells. In a wound healing model, ligand-receptor signaling prediction identified putative interactions between SnC SASP and myeloid cells that were validated by immunofluorescent staining and in vitro coculture of SnCs and macrophages. Collectively, we have found that our SenSig transfer learning strategy from an in vivo signature outperforms in vitro -derived signatures and identifies conserved and tissue-specific SnCs and their SASP, independent of p16 Ink4a expression, and may be broadly applied to elucidate SnC identity and function in vivo .
Mg2+–Ca2+ interaction in contractility of vascular smooth muscle: Mg2+ versus organic calcium channel blockers on myogenic tone and agonist-induced responsiveness of blood vessels (1987)

Contractility of all types of invertebrate and vertebrate muscle is dependent upon the actions and interactions of two divalent cations, viz, calcium (Ca2+) and magnesium (Mg2+) ions. The data presented and reviewed herein contrast the actions of several organic Ca2+ channel blockers with the natural, physiologic (inorganic) Ca2+ antagonist, Mg2+, on microvascular and macrovascular smooth muscles. Both direct in vivo studies on microscopic arteriolar and venular smooth muscles and in vitro studies on different types of blood vessels are presented. It is clear from the studies done so far that of all Ca2+ antagonists examined, only Mg2+ has the capability to inhibit myogenic, basal, and hormonal-induced vascular tone in all types of vascular smooth muscle. Data obtained with verapamil, nimopidine, nitrendipine, and nisoldipine on the microvasculature are suggestive of the probability that a heterogeneity of Ca2+ channels, and of Ca2+ binding sites, exists in different microvascular smooth muscles; although some appear to be voltage operated and others, receptor operated, they are probably heterogeneous in composition from one vascular region to another. Mg2+ appears to act on voltage-, receptor-, and leak-operated membrane channels in vascular smooth muscle. The organic Ca2+ channel blockers do not have this uniform capability; they demonstrate a selectivity when compared with Mg2+. Mg2+ appears to be a special kind of Ca2+ channel antagonist in vascular smooth muscle. At vascular membranes it can (i) block Ca2+ entry and exit, (ii) lower peripheral and cerebral vascular resistance, (iii) relieve cerebral, coronary, and peripheral vasospasm, and (iv) lower arterial blood pressure. At micromolar concentrations (i.e., 10-100 microM). Mg2+ can cause significant vasodilatation of intact arterioles and venules in all regional vasculatures so far examined. Although Mg2+ is three to five orders of magnitude less potent than the organic Ca2+ channel blockers, it possesses unique and potentially useful Ca2+ antagonistic properties.
A 5‘-(Trifluoromethyl)anthracycline Glycoside:  Synthesis of Antitumor-Active 7-O-(2,6-Dideoxy-6,6,6-trifluoro-α-l-lyxo-hexopyranosyl)adriamycinone (1996)

7-O-(2,6-Dideoxy-6,6,6-trifluoro-alpha-L-lyxo-hexopyranosyl)adriam ycinone (3), whose substituent at C-5' is a lipophilic trifluoromethyl group, has been prepared by coupling of 3,4-di-O-acetyl-2,6-dideoxy-6,6,6-trifluoro-alpha-L-lyxo-hexopyran osyl bromide (20) with 14-O-(tert-butyldimethylsilyl)adriamycinone under the Koenigs-Knorr conditions. The key step in this synthesis was the C-trifluoromethylation of 5-O-acetyl-2,3-di-O-benzyl-4-deoxy-aldehydo-L-erythro-pentose (10), derived from D-lyxose in 10 steps, with (trifluoromethyl)trimethylsilane in the presence of tetrabutylammonium fluoride, whereupon 1,1,1-trifluoro-L-arabino-hexitol (11) was obtained along with its 2-epimer. The synthetic product 3 showed remarkable antitumor activity in vivo in a low dose range compared to the analogs including doxorubicin. The fact may be ascribed to the presence of a trifluoromethyl group at C-5', suggesting the importance of the group in view of biological activity.
ChemInform Abstract: Regiospecific Synthesis of Polysubstituted Naphthalenes and Iodoacylnaphthoquinones via Zirconocene Complexes of Naphthalynes. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Advanced liquid crystal materials with negative dielectric anisotropy for monitor and TV applications (2003)

The Vertically Aligned (VA) technology is one of the newer modes of operation among TFT displays. For VA displays, the liquid crystal is aligned homeotropically and possess a negative dielectric anisotropy (De<0) in order to switch perpendicular to an applied electric field. A new generation of nematic LC materials has been developed which reduces rotational viscosity (g1) but keeps other important parameters unchanged. The switching time parameter, g1/Dn2, is compared with those of previous reference mixtures possessing a range of optical anisotropies. The results show that the new mixtures give a consistent reduction in g1/Dn2 for a wide spread of Dn. Reduction in threshold voltage (V0) is an important goal for the majority of applications and can be achieved by increasing the absolute magnitude of (formula available in paper). However this in turn increases rotational viscosity (g1). The new mixtures overcome this drawback and significantly decrease the values of g1/Dn2 over a wide range of V0. A requirement for TV displays is increased brightness. The result is an increased operating temperature and therefore, higher clearing temperatures of the LC mixtures are demanded, but they lead to higher g1. The new LC components were successful in reducing g1/Dn2 in comparison with the previous standards for a range of clearing points.
Examination of the optical transmission through metallic nano‐apertures (2007)

Abstract There have been tremendous interests about the near‐field optical effect through a sub‐wavelength size metallic aperture. In this report, the computational experiments using the finite‐difference time‐domain (FDTD) method has been performed to examine the optical transmission intensity through the small apertures. In the case that the aperture size is very large compared with the wavelength of the light, the diffracted angle is small and the perpendicular component of the propagation vector is greater than the parallel component of the propagation vector. With decreasing the aperture diameter, the diffraction angle becomes greater and the parallel component of the propagation vector becomes greater. For the aperture diameter smaller than the wavelength of the incident light, the conventional diffraction formula no longer becomes valid. The FDTD simulations are performed to obtain the light intensity distribution transmitted through the various diameters of the apertures. In addition, the FDTD simulation is also carried out to examine the characteristics of the apertures on double layer metallic plate structure. (© 2007 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)