gebhart/patrepeval huggingface dataset:
Thioredoxin Reductase-2 Is Essential for Keeping Low Levels of H2O2 Emission from Isolated Heart Mitochondria (2011)

Respiring mitochondria produce H(2)O(2) continuously. When production exceeds scavenging, H(2)O(2) emission occurs, endangering cell functions. The mitochondrial peroxidase peroxiredoxin-3 reduces H(2)O(2) to water using reducing equivalents from NADPH supplied by thioredoxin-2 (Trx2) and, ultimately, thioredoxin reductase-2 (TrxR2). Here, the contribution of this mitochondrial thioredoxin system to the control of H(2)O(2) emission was studied in isolated mitochondria and cardiomyocytes from mouse or guinea pig heart. Energization of mitochondria by the addition of glutamate/malate resulted in a 10-fold decrease in the ratio of oxidized to reduced Trx2. This shift in redox state was accompanied by an increase in NAD(P)H and was dependent on TrxR2 activity. Inhibition of TrxR2 in isolated mitochondria by auranofin resulted in increased H(2)O(2) emission, an effect that was seen under both forward and reverse electron transport. This effect was independent of changes in NAD(P)H or membrane potential. The effects of auranofin were reproduced in cardiomyocytes; superoxide and H(2)O(2) levels increased, but similarly, there was no effect on NAD(P)H or membrane potential. These data show that energization of mitochondria increases the antioxidant potential of the TrxR2/Trx2 system and that inhibition of TrxR2 results in increased H(2)O(2) emission through a mechanism that is independent of changes in other redox couples.
Ambipolar Plasmon‐Enhanced Photodetector Built on Germanium Nanodots Array/Graphene Hybrid (2020)

Abstract Graphene with gate‐tunable electronic properties is promising as the channel materials in ambipolar multifunctional photodetectors. However, owing to the zero bandgap and weak light absorption, photodetectors fabricated on pristine graphene have low photoresponsivity. Herein, an ambipolar multifunctional photodetector with improved photocurrent and response speed is constructed on germanium (Ge) nanodots array‐decorated graphene. The photocurrent map and simulated electric field distributions reveal that the enhanced photo‐response is attributed to the localized surface plasmonic resonance effects by trapping light around the Ge nanodots. The photodetector exhibits ambipolar photo‐response and the photocurrents can be tuned from negative to positive by applying different gate voltages due to the gate‐tunable Fermi level of graphene. This ambipolar photodetector with fast response has excellent potential in imaging and sensing arrays as well as multifunctional photodetectors.
P339 Gradient adjusted cardiac power index does not improve prediction of survival post transcatheter aortic valve replacement compared to cardiac power index alone (2020)

Abstract Funding Acknowledgements None Background Cardiac Power Index (CPI) is an integrative hemodynamic measure of cardiac pumping capability and is the product of the simultaneously measured mean arterial pressure (MAP) and cardiac output (CO). In patients with aortic stenosis (AS), MAP is not reflective of mean systolic left ventricular (LV) pressure due to the transvalvular gradient. Non-invasive assessment of mean systolic LV pressure is challenging in severe aortic stenosis. CPI assessed using systemic MAP was previously shown to predict survival post transcatheter aortic valve replacement (TAVR). Purpose We evaluated the utility of a gradient adjusted CPI in predicting survival post TAVR compared to CPI alone Methods A retrospective study was performed including patients undergoing TAVR with 1 year follow-up. Baseline demographics, clinical, and echocardiographic data were abstracted from a cohort of 1,011 patients. CPI was calculated, (CO x MAP)/ (451 x BSA) Watts/m2. Gradient adjusted CPI was calculated using an augmented MAP i) adding aortic valve mean gradient(AVMG) to systolic blood pressure (CPI1); ii) adding aortic valve maximal instantaneous gradient to systolic blood pressure (CPI2) and iii) adding AVMG to MAP (CPI3). Patient survival score was calculated using a step up technique to identify the cut off value for CPI and gradient adjusted CPI to identify, where the maximum difference in mortality occurred. Multivariate cox-regression analysis was performed to adjust for baseline covariates. Receiver operator curves(ROC) for CPI and gradient adjusted CPI were calculated to predict survival post TAVR. Results The mortality rate at 1 yr was 16%. Mean age and AVMG of survivors was 81 +/- 9 yrs and 43 +/-14 mmHg vs 80 +/-9 yrs and 42 +/- 13 mmHg in the deceased group. Proportion of female patients was similar in both groups (p = 0.7). Patients in the deceased group at baseline had a higher prevalence of chronic lung disease, atrial fibrillation, heart failure within 2-weeks of procedure, higher STS-PROM score, lower serum albumin level, higher prevalence of moderate to severe tricuspid regurgitation, higher right ventricular systolic pressure and higher prevalence of dialysis. Both CPI and gradient adjusted CPI were independently associated with survival at 1 year. The area under ROC for CP, CP1, CP2 and CP3 were 0.67 (95% confidence interval [CI] 0.62 - 0.72), 0.65 (95% CI 0.60 – 0.70), 0.66 (95% CI 0.61 – 0.71) and 0.63 (95% CI 0.58 – 0.68) respectively. Conclusion Gradient adjusted CPI did not improve accuracy of predicting post TAVR survival at 1 year compared to CPI alone. Abstract P339 Figure. Area under ROC
Low-Loss Matching Network Design for Band-Switchable Multi-Band Power Amplifier (2012)

This paper presents a novel design scheme for a band-switchable multi-band power amplifier (BS-MPA). A key point of the design scheme is configuring multi-section reconfigurable matching networks (MR-MNs) optimally in terms of low loss matching in multiple frequency bands from 0.7 to 2.5GHz. The MR-MN consists of several matching sections, each of which has a matching block connected to a transmission line via a switch. Power dissipation at an actual on-state switch results in the insertion loss of the MR-MN and depends on how the impedance is transformed by the MR-MN. The proposed design scheme appropriately transforms the impedance of a high power transistor to configure a low loss MR-MN. Numerical analyses show quantitative improvement in the loss using the proposed scheme. A 9-band 3-stage BS-MPA is newly designed following the proposed scheme and fabricated on a multi-layer low temperature co-fired ceramic substrate for compactness. The BS-MPA achieves a gain of over 30dB, an output power of greater than 33dBm and a power added efficiency of over 40% at the supply voltage of 4V in each operating band.
An Equivalent Synchronization for Phasor Measurements in Power Networks (2017)

This paper deals with the problem of synchronizing phasor measurements in different nodes of a power network. Usually, this issue is faced by using a synchronization signal provided by wired or wireless communication infrastructure. As it is well known, the most common implementation of such a solution is the so-called Phasor Measurement Unit (PMU) which relies on a time reference signal coming from the GPS system. In this work, an alternative approach based on asynchronous measurements is presented and discussed. In particular, it is firstly shown how an equivalent synchronization among different nodes can be obtained by performing voltage and current measurements in all the nodes of the considered network. After that, an equivalent synchronization when only 75% of the nodes are monitored, is presented.
Fractional re-distribution among cell motility states during ageing (2021)

Ageing in humans is associated with the decreased capacity to regulate cell physiology. Cellular properties, such as cell morphology and mechanics, encode ageing information, and can therefore be used as robust biomarkers of ageing. Using a panel of dermal fibroblasts derived from healthy donors spanning a wide age range, we observe an age-associated decrease in cell motility. By taking advantage of the single-cell nature of our motility data, we classified cells based on spatial and activity patterns to define age-dependent motility states. We show that the age-dependent decrease in cell motility is not due to the reduced motility of all cells, but results from the fractional re-distribution among motility states. These findings highlight an important feature of ageing cells characterized by a reduction of cellular heterogeneity in older adults relative to post-adolescent/adults. Furthermore, these results point to a mechanistic framework of ageing, with potential applications in deciphering emergent ageing phenotypes and biomarker development.
Hydrogen Adsorption in Metal–Organic Frameworks: Cu‐MOFs and Zn‐MOFs Compared (2006)

Abstract Hydrogen adsorption in two different metal–organic frameworks (MOFs), MOF‐5 and Cu‐BTC (BTC: benzene‐1,3,5‐tricarboxylate), with Zn 2+ and Cu 2+ as central metal ions, respectively, is investigated at temperatures ranging from 77 K to room temperature. The process responsible for hydrogen storage in these MOFs is pure physical adsorption with a heat of adsorption of approximately –4 kJ mol –1 . With a saturation value of 5.1 wt.‐% for the hydrogen uptake at high pressures and 77 K, MOF‐5 shows the highest storage capacity ever reported for crystalline microporous materials. However, at low pressures Cu‐BTC shows a higher hydrogen uptake than MOF‐5, making Cu‐based MOFs more promising candidates for potential storage materials. Furthermore, the hydrogen uptake is correlated with the specific surface area for crystalline microporous materials, as shown for MOFs and zeolites.
Synthesis and Characterization of the Cobalt Complexes of New BF2 + Bridged, Anthracene Substituted Bis(a-Dioxime) Macrocycles (1991)

Abstract The synthesis, characterization and structure are described for new cobalt complexes, with a BF2 + bridged, bis(a-dioxime) ligand, based upon a sterically demanding framework derived from an anthracene Diels-Alder adduct. The ligand provides a deep cleft within which axial ligands and/or O2 can bind. The crystal structures of the bis- and mono(BF2 +) bridged complexes have space groups P21/c and P I, respectively, with unit cell dimensions a = 12.662(2) Å, b = 16.430(3) Å, c = 10.438(3) Å, β = 103.51(2)°, a = 12.046(1)Å, b = I7.596(3)Å, c = 9.939(I)Å, a = 105.15(1)°, β = 102.87(1)°, and γ = 78.13(1), respectively. For both complexes Z = 2 and the residuals R and R w were 0.070, 0.104, and 0.059, 0.075, respectively. ESR studies show that the cobalt(II) complexes have a strong tendency to bind two axial nitrogen bases, adopting a coordination number of six. The dioxygen affinity of the new cobalt(II) dioxygen carrier is limited by the competition between axial base binding and O2 binding. This extends the understanding of correlations between electrode potentials and O2 affinities and possible sources of apparent contradictions.
Measurement Manipulation and Space Selection in Network Coordinates (2008)

Internet coordinate systems have emerged as an efficient method to estimate the latency between pairs of nodes without any communication between them. However, most coordinate systems have been evaluated solely on data sets built by their authors from measurements gathered over large periods of time. Although they show good prediction results, it is unclear whether the accuracy is the result of the system design properties or is more connected to the characteristics of the data sets. In this paper, we revisit a simple question: how do the features of the embedding space and the inherent attributes of the data sets interact in producing good embeddings? We adapt the Vivaldi algorithm to use Hyperbolic space for embedding and evaluate both Euclidean and Hyperbolic Vivaldi on seven sets of real-world latencies. Our results show that node filtering and latency distributions can significantly influence the accuracy of the predictions. For example, although Euclidean Vivaldi performs well on data sets that were chosen, constructed and filtered by the designers of the algorithm, its performance and robustness decrease considerably when run on third party data sets that were not filtered a priori. Our results offer important insight into designing and building coordinate systems that are both robust and accurate in Internet-like environments.
Microwave plasma generation of arsine from hydrogen and solid arsenic (1990)

The generation of arsine from the reactions of hydrogen and elemental arsenic in a microwave plasma reactor is described. The arsenic is evaporated from a solid source upstream and carried into the microwave plasma region by a mixture of hydrogen and argon. Stable reaction products, arsine and diarsine are observed by molecular beam sampled mass spectroscopy along with partially hydrogenated species (e.g., AsH and AsH2). The effect of composition and flow rate of the argon/hydrogen carrier gas mixture on the amount of arsine generated is investigated. The arsine production reaches a maximum for an argon-to-hydrogen ratio of unity indicating that metastable argon species act as energy transfer intermediates in the overall reaction. The generation of arsine and diarsine from easily handled solid arsenic by this technique makes it attractive as a possible arsenic source for the growth of compound semiconductors by low-pressure metalorganic chemical vapor deposition.&amp;lt;lz&amp;gt; &amp;lt;lz&amp;gt; &amp;lt;lz&amp;gt; &amp;lt;lz&amp;gt; &amp;lt;lz&amp;gt;
ChemInform Abstract: Discovery of 1‐(4‐Fluorophenyl)‐(3R)‐ [3‐(4‐fluorophenyl)‐(3S)‐hydroxypropyl] ‐(4S)‐(4‐hydroxyphenyl)‐2‐azetidinone (SCH 58235): A Designed, Potent, Orally Active Inhibitor of Cholesterol Absorption. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Kappa (2020)

Serverless computing has recently emerged as a new paradigm for running software on the cloud. In this paradigm, programs need to be expressed as a set of short-lived tasks, each of which can complete within a short bounded time (e.g., 15 minutes on AWS Lambda). Serverless computing is beneficial to cloud providers---by allowing them to better utilize resources---and to users---by simplifying management and enabling greater elasticity. However, developing applications to run in this environment is challenging, requiring users to appropriately partition their code, develop new coordination mechanisms, and deal with failure recovery. In this paper, we propose Kappa, a framework that simplifies serverless development. It uses checkpointing to handle lambda function timeouts, and provides concurrency mechanisms that enable parallel computation and coordination.
Comparison of Low-Power Implementations of Trivium and Grain (2007)

Abstract. This paper provides a comparison of the two stream cipher proposals Grain and Trivium which are candidates in the hardware focus phase of the eSTREAM project. We evaluate these algorithms concerning their feasibility to implement them for low-power applications in RFID systems. A triple of parameters which includes the chip area, the power consumption, and the number of clock cycles for encrypting a fixed amount of data is introduced which allows a fair comparison of the proposals. The datapaths of the implementations are presented in detail and the synthesis results are shown. A comparison of the results of Grain and Trivium with an AES implementation shows that the chip area of Trivium is slightly smaller while Grain requires less clock cycles for encrypting 128 bits of data. The low-power implementations of the stream ciphers require only a fourth of the mean current consumption of the AES algorithm.
Immobilized enzyme cellulose hollow fibers: I. Immobilization of heparinase (1989)

The immobilization of heparinase to tresyl-chloride-activated cellulose hollow fibers for the removal of heparin from the bloodstream was examined. Whole blood can be circulated through cellulose hollow fibers without hemolysis and the tresyl chloride chemistry provides a strong linkage which limits the release of the enzyme from the support. The tresylation and immobilization methods were modified and optimized to improve the heparinase activity retained by cellulose. Pretreatment of the hollow fibers with 0.05/V sodium hydroxide increased the degree of tresylation and the immobilization yield by a factor of five. The use of triethylamine as the organic base in the tresyl chloride activation resulted in threefold greater activity retention by the support than when pyridine was used. Together, sodium hydroxide pretreatment and triethylamine enhanced the activity retained by cellulose to 26.2 +/- 7.0% of that bound to the support. The activity retention was also a function of the technique used for immobilization. The best results were achieved when the enzyme was applied to the activated fibers once every 12 to 24 h for a total of four times. The active enzyme loading on the fibers was 0.3 mg heparin degraded/h cm(2) when 4.5 microg protein/cm(2) was bound to the fibers.
Operating Latency Sensitive Applications on Public Serverless Edge Cloud Platforms (2020)

Cloud native programming and serverless architectures provide a novel way of software development and operation. A new generation of applications can be realized with features never seen before while the burden on developers and operators will be reduced significantly. However, latency sensitive applications, such as various distributed IoT services, generally do not fit in well with the new concepts and today's platforms. In this article, we adapt the cloud native approach and related operating techniques for latency sensitive IoT applications operated on public serverless platforms. We argue that solely adding cloud resources to the edge is not enough and other mechanisms and operation layers are required to achieve the desired level of quality. Our contribution is threefold. First, we propose a novel system on top of a public serverless edge cloud platform, which can dynamically optimize and deploy the microservice-based software layout based on live performance measurements. We add two control loops and the corresponding mechanisms which are responsible for the online reoptimization at different timescales. The first one addresses the steady-state operation, while the second one provides fast latency control by directly reconfiguring the serverless runtime environments. Second, we apply our general concepts to one of today's most widely used and versatile public cloud platforms, namely, Amazon's AWS, and its edge extension for IoT applications, called Greengrass. Third, we characterize the main operation phases and evaluate the overall performance of the system. We analyze the performance characteristics of the two control loops and investigate different implementation options.
Intracerebral grafting of neuronal cell suspensions. VIII. Cell survival and axonal outgrcwth of dcpaminergic and cholinergic cells in the aged brain. (1983)

Neuronal cell suspensions prepared from the ventral mesencephalon and the septal-diagonal band area of rat embryos were implanted into the depth of the intact neostriatum or hippocampus of 21-23 month old female rats. Graft survival, assessed 3-4 months after grafting, was comparable to that seen in our previous studies of young adult recipients. Fibre outgrowth into the host brain was evaluated in animals which were subjected to lesions of the intrinsic nigrostriatal or septohippocampal system 6-10 days before killing. Dense dopamine fibre outgrowth was seen within a zone of up to about 1 mm radius around the nigral implants, and dense growth of acetylcholine esterase (AChE) positive fibres occurred up to about 2 mm away from the septal implants. The overall magnitude of fibre outgrowth was less than that generally seen in previously denervated targets in young adult recipients, but it appeared to be as extensive as in young recipients when the grafts are placed in non-denervated targets. The distribution of the AChE-positive fibres from the septal implants in the host hippocampus suggested that the pattern found in the non-denervated target of the aged recipients was more diffuse, and partly different, from normal, and that age-dependent synapse loss in intrinsic connections may influence the patterning of the graft-derived innervation.
N‐Pyrrolyl‐[N,N,N]‐bis(imino)pyridyl iron(II) and cobalt(II) olefin polymerization catalysts (2002)

Abstract A series of new [ N,N,N ] 2,6‐bis(imino)pyridyl iron and cobalt halide complexes as precatalysts for the homo‐ and co‐polymerization of ethylene has been synthesized and evaluated for their catalytic performance. The novel key structural feature of these [ N , N , N ]MCl 2 catalysts is their peripheral substitution with bulky N ‐heterocyclic groups, including substituted N ‐pyrrolyl, N ‐indolyl, N ‐carbazolyl, and N ‐triazolyl moieties. The synthesis starts with the corresponding N ‐amino‐ N ‐heterocycles, which were prepared by a modified Paal–Knorr condensation of 1,4‐diketones with mono‐protected hydrazines, or by electrophilic amination of benzannelated azoles. Condensation with 2,6‐diacetylpyridine or 2,5‐diformylthiophene afforded 14 different terdentate ligands, and complex formation with iron(II), iron(III), cobalt(II) yielded 23 different precatalysts. A single crystal structure analysis of one representative showed that these paramagnetic complexes have a distorted trigonal bipyramidal structure with orthogonal sterically shielding N ‐azolyl groups. All the methylalumoxane‐activated iron(II) and cobalt(II) complexes with N ‐pyrrolyl, N ‐indolyl, and N ‐carbazolyl substituents are highly active catalysts for the homo‐ and co‐polymerization of ethylene, producing polymers with comparatively narrow molecular weight distributions and with a wide range of molecular weights, dependent on the substitution pattern of the peripheral N ‐azolyl substituents. The observed microstructures of the polymers vary from very highly branched to mostly linear, giving access to oligomers and polymers with an unusual broad spectrum of macroscopic physical properties. Copyright © 2002 John Wiley &amp; Sons, Ltd.
10 W average power frequency comb with sub-mHz relative linewidths from an Yb:fiber system (2008)

We present a fully phase-stabilized frequency comb with 10 W average power and 136 MHz repetition rate produced by a Yb:fiber system. Direct comparison with an octave-spanning Ti:sapphire comb yields record-low sub-mHz relative linewidths for frequency combs.
MK800-62F1, a New Inhibitor of Apoptotic Cell Death, from Streptomyces diastatochromogenes MK800-62F1. II. Structure Elucidation. (2000)

A new compound, MK800-62F1, was isolated from a cultured broth of Streptomyces diastatochromogenes MK800-62F1. The structure was determined by NMR analysis and degradation experiments.
A Comprehensive Appraisal of Risk Prediction Models for Cardiogenic Shock (2022)

Despite advances in early revascularization, percutaneous hemodynamic support platforms, and systems of care, cardiogenic shock (CS) remains associated with a mortality rate higher than 50%. Several risk stratification models have been derived since the 1990 s to identify patients at high risk of adverse outcomes. Still, limited information is available on the differences between scoring systems and their relative applicability to both acute myocardial infarction and advanced decompensated heart failure CS. Thus, we reviewed the similarities, differences, and limitations of published CS risk prediction models and herein discuss their suitability to the contemporary management of CS care.