gebhart/patrepeval huggingface dataset:
Neuartige Rhenium(v)‐Carbonato‐ und ‐Sulfato‐Chelatkomplexe: Synthesen und 17O‐NMR‐spektroskopisch untersuchte Moleküldynamik (1987)

Der vollständige Austausch aller O‐Atome im Sulfato‐Komplex 3 konnte durch 17 O‐NMR‐Spektroskopie nachgewiesen werden. 3 und das Carbonato‐Analogon 2 können einfach aus 1 und Ag 2 SO 4 bzw. Ag 2 CO 3 synthetisiert werden . magnified image
Opportunistic communications for networked controlled systems of autonomous vehicles (2010)

Situational awareness requires maintaining a reasonable level of communication connectivity in networks of autonomous vehicles. It is difficult to overcome deep fading from time-varying wireless channels in a dynamic and resource constrained environment. Moreover, other system constraints such as the energy consumption and total operation time make the design of communication protocols for such systems more challenging. In this paper, we consider the problem of efficient communications between a group of autonomous vehicles with energy consumption and total operation time constraints in an adversarial environment. We show that the policy of continuously attempting to communicate reliably over the course of the mission may lead to considerable system degradation. We propose an adaptive algorithm to make communication attempts opportunistically, based on the qualities of the wireless channels as the vehicles move throughout the terrain. We compare the proposed algorithm with a non-opportunistic algorithm in which the vehicles blindly attempt to communicate regularly throughout the course of the mission. We show that the proposed algorithm significantly improves the system performance, both in terms of operation time when the agents transmit only situational information and data throughput when additional data transmission is necessary.
Evaluación de las actividades de promoción de consumo de frutas y verduras en 8 países miembros de la Alianza Global de Promoción al Consumo de Frutas y Hortalizas “5 al día” – AIAM5 (2016)

Introducción: Este artículo recopila las prácticas de promoción del consumo de frutas y verduras por parte de ocho miembros de AIAM5 - Alianza Global de Promoción al Consumo de Frutas y Hortalizas “5 al día”, con el objetivo de identificar buenas prácticas en el planteamiento de estrategias, programas y actividades para la promoción del consumo de frutas y hortalizas.Material y Métodos: Se empleó un cuestionario diseñado para categorizar e identificar fortalezas, debilidades, oportunidades, costo-efectividad, viabilidad, así como las prácticas de mayor potencial para adaptarse a políticas de promoción de salud nacionales. Se evaluaron cuestionarios procedentes de ocho países de la AIAM5: México, Chile, Costa Rica, Venezuela, Colombia, Bolivia, Nicaragua y España.Resultados: Una de las grandes fortalezas de las entidades que conforman AIAM5 es el prestigio y conocimiento académico, profesional y técnico que respalda sus actividades. Se evidenció la debilidad de sus estrategias por la falta de medición del impacto de sus actividades y evaluación de costo-efectividad. También se evidenció que algunas entidades que lideran programas “5 al día” son concebidas como empresas sociales con diversidad de tipos de socios y aliados.Conclusiones: Se recomienda que los miembros de AIAM5 hagan un esfuerzo para medir el impacto de las actividades e intervenciones que realicen, estableciendo objetivos cuantificables mediante indicadores que permitan evaluar el grado de alcance de las acciones llevadas a cabo. Así mismo, es recomendable que exploten el nicho de oportunidades que ofrece la Responsabilidad Social Corporativa, para alcanzar sus objetivos de promoción del consumo de frutas y verduras.
Abstract 3663: Discovery of sulfonamide-piperidinones as potent inhibitors of the MDM2-p53 protein-protein interaction (2015)

Abstract The p53 tumor suppressor is controlled by MDM2, which binds p53 and negatively regulates its transcriptional activity and stability. Many tumors overproduce MDM2 to impair p53 function. Therefore, restoration of p53 activity by inhibiting p53-MDM2 binding represents an attractive, novel approach to cancer therapy. We previously reported the discovery of AM-8553, a potent and selective piperidinone inhibitor of the MDM2-p53 interaction (Rew et al. J. Med. Chem. 2012, 55, 4936). We report here continued optimization of the N-alkyl substituent of this series, focused in particular on a previously underutilized interaction in a shallow cleft on the MDM2 surface that led to the discovery of a variety of extremely potent sulfonamides such as 14 with an IC50 of 5.3 nM in the cell proliferation assay. The compound 14 interacts specifically with the p53-binding pocket of MDM2 and releases the p53 protein from negative control. Treatment of cancer cells expressing wild-type p53 with sulfonamide 14 stabilizes p53 and activates the p53 pathway, leading to cell cycle arrest and apoptosis. The compound 14 showed excellent efficacy and caused tumor regression in the SJSA-1 tumor xenograft model. Citation Format: Zhihong Li, Jiasheng Fu, Yosup Rew, Michael W. Gribble, Jude Canon, Ada Chen, John Eksterowicz, Xin Huang, Lixia Jin, Mei-Chu Lo, Lawrence R. McGee, Tao Osgood, Anne Y. Saiki, Paul Shaffer, Daqing Sun, Sarah Wortman, Qiuping Ye, Dongyin Yu, Xiaoning Zhao, Jing Zhou, Jonathan D. Oliner, Steve H. Olson, Julio C. Medina. Discovery of sulfonamide-piperidinones as potent inhibitors of the MDM2-p53 protein-protein interaction. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3663. doi:10.1158/1538-7445.AM2015-3663
Review and kinetic analysis of the photodegradation of UV absorbers (1997)

Abstract Ultraviolet absorbers (UVA's) undergo photodegradation with quantum yields on the order of 10 −6 even in glassy, unreactive matrices such as poly(methyl methacrylate) (PMMA). The kinetics of UVA loss in a film or coating can be described by the equation: A = log 10 [(1‐T o )10 + 1] where A is the absorbance at time t, T o is the initial transmission, A o is the initial absorbance, and k is an “infinite absorption” zero order rate constant. The derivation and implications of this equation and a general review of UVA degradation chemistry are discussed.
DIFFERENTIAL EFFECTS OF CYCLOSPORINE AND RAPAMYCIN ON COSTIMULATION BLOCKADE INDUCED ALLOGRAFT TOLERANCE: INTRAGRAFT CTL GENE EXPRESSION ANALYSIS (1999)

827 In concert with others we have demonstrated that combined anti-CD40L and CTLA-4Ig (costimulation blockade) treatment produce long-term cardiac allograft survival in mice and that cyclosporine (CsA) totally blocked the costimulation blockade induced allograft tolerance. In contrast, rapamycin (RPM) plus costimulation blockade enables tolerance induction. The mechanism by which CsA and RPM exert differential effects on costimulation blockade induced tolerance is unknown. In the present study, we examined intragraft gene expression of CTL attacking molecules FasL and Granzyme B in recipient mice treated with CTLA-4Ig and anti-CD40L, CsA, RPM, as well as combined treatment with CTLA-4Ig and anti-CD40L plus CsA or RPM. We found that: 1) costimulation blockade markedly inhibited granzyme B and FasL gene expression as compared to untreated controls; 2) costimulation blockade plus RPM completely abolished intragraft expression of FasL and granzyme B; 3) costimulation blockade plus CsA failed to block FasL and granzyme B gene expression. We conclude that the biological effect of CsA and RPM on costimulation blockade induced tolerance is strikingly different and CsA and RPM have different effects on expression of CTL markers.
Motion Feature Extraction Using Second-order Neural Network and Self-organizing Map for Gesture Recognition (2005)

We propose a neural preprocess approach for video-based gesture recognition system. Second-order neural network (SONN) and self-organizing map (SOM) are employed for extracting moving hand regions and for normalizing motion features respectively. The SONN is more robust to noise than frame difference technique. Obtained velocity feature vectors are translated into normalized feature space by the SOM with keeping their topology, and the transition of the activated node in the topological map is classified by DP matching. The topological nature of the SOM is quite suited to data normalization for the DP matching technique. Experimental results show that those neural networks effectively work on the gesture pattern recognition. The SONN shows its noise reduction ability for noisy backgrounds, and the SOM provides the robustness to spatial scaling of input images. The robustness of the SOM to spatial scaling is based on its robustness to velocity scaling.
Passive in-home health and wellness monitoring: Overview, value and examples (2009)

Modern sensor and communication technology, coupled with advances in data analysis and artificial intelligence techniques, is causing a paradigm shift in remote management and monitoring of chronic disease. In-home monitoring technology brings the added benefit of measuring individualized health status and reporting it to the care provider and caregivers alike, allowing timely and targeted preventive interventions, even in home and community based settings. This paper presents a paradigm for geriatric care based on monitoring older adults passively in their own living settings through placing sensors in their living environments or the objects they use. Activity and physiological data can be analyzed, archived and mined to detect indicators of early disease onset or changes in health conditions at various levels. Examples of monitoring systems are discussed and results from field evaluation pilot studies are summarized. The approach has shown great promise for a significant value proposition to all the stakeholders involved in caring for older adults. The paradigm would allow care providers to extend their services into the communities they serve.
Supplementary Materials and Methods from The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression (2023)

&lt;p&gt;PDF file - 233K, This file contains supplemental materials and methods, including cell lines, antibodies and staining procedures used in this study&lt;/p&gt;
FAC1, a Novel Gene Identified with the Monoclonal Antibody Alz50, Is Developmentally Regulated in Human Brain (Part 2 of 2) (1995)

The monoclonal antibody Alz50 recognizes both neurofibrillary pathology associated with Alzheimer's disease and subplate neurons in the developing human brain. To attempt to identity Alz50 antigens expressed during development, a human fetal brain cDNA library was immunoscreened. A positive clone was isolated and sequenced. The clone represents a novel gene named FAC1 (Fetal Alz-50-Reactive Clone 1). The FAC1 gene is located on human chromosome 17 and is conserved across species. In the human fetal brain, the FAC1 gene product is abundantly expressed and the protein is located both in the nucleus and the cytoplasm of cells throughout the developing cortex. Decreased levels of FAC1 protein are observed in adult brain by immunoblot analysis. By immunocytochemistry, the FAC1 protein is almost exclusively localized in the nucleus of neurons in the adult neocortex. Therefore, expression of the FAC1 gene is developmentally regulated and the cellular localization of the protein product is altered during development.
Surrogate Modeling for Simultaneous Engine Cycle and Technology Optimization for Next Generation Subsonic Aircraft (2012)

This paper presents an engine sizing and cycle selection study of ultra high bypass ratio engines applied to a subsonic commercial aircraft in the N+2 (2025) timeframe. NASA has created the Environmentally Responsible Aviation (ERA) project to serve as a technology transition bridge between fundamental research (TRL 1–4) and potential commercial application (TRL 7). Specifically, ERA is focused on subsonic transport technologies that could reach TRL 6 by 2020 and can be integrated into an advanced vehicle concept to simultaneously meet the ERA project metrics for noise, emissions, and fuel burn. An important variable in exploring the technology trade space is the selection of the optimal engine cycle for use on the advanced aircraft. Previous literature demonstrated the cycle optimization using a design of experiments (DOE) to explore the engine cycle design space for a pre-defined technology package. However, since the optimal engine cycle is dependent upon the specific technology package, this process would have to be repeated to ensure optimal performance for each technology package. With more than 80 technologies to be analyzed, the combinatorial space of technology packages is enormous. As a result, executing a DOE to find the optimum engine cycle for each technology package is infeasible. To address this issue, it is proposed to use surrogate models that encompass the engine cycle and technology design space to enable fast and accurate optimization of the engine cycle for any given technology package. This paper describes the generation and analysis of surrogate models used for technology assessment and cycle optimization of an ultra high bypass geared turbofan engine architecture. The first study in the paper shows that a single surrogate model can be used to accurately simulate both a technology and cycle design space. To demonstrate the proposed surrogate modeling approach, the cycle design space for three different technology packages was analyzed. This study demonstrated that when an optimal cycle is found within the constrained interior of a design space, the surrogate modeling approach is quite accurate. The study also established that the surrogate models can also be used to assess potential cycles at the boundaries or even outside of the region for which they were trained.
Practical Applications of Sparse Modeling (2014)

Sparse modeling is a rapidly developing area at the intersection of statistical learning and signal processing, motivated by the age-old statistical problem of selecting a small number of predictive variables in high-dimensional datasets. This collection describes key approaches in sparse modeling, focusing on its applications in fields including neuroscience, computational biology, and computer vision. Sparse modeling methods can improve the interpretability of predictive models and aid efficient recovery of high-dimensional unobserved signals from a limited number of measurements. Yet despite significant advances in the field, a number of open issues remain when sparse modeling meets real-life applications. The book discusses a range of practical applications and state-of-the-art approaches for tackling the challenges presented by these applications. Topics considered include the choice of method in genomics applications; analysis of protein mass-spectrometry data; the stability of sparse models in brain imaging applications; sequential testing approaches; algorithmic aspects of sparse recovery; and learning sparse latent models.ContributorsA. Vania Apkarian, Marwan Baliki, Melissa K. Carroll, Guillermo A. Cecchi, Volkan Cevher, Xi Chen, Nathan W. Churchill, Rmi Emonet, Rahul Garg, Zoubin Ghahramani, Lars Kai Hansen, Matthias Hein, Katherine Heller, Sina Jafarpour, Seyoung Kim, Mladen Kolar, Anastasios Kyrillidis, Aurelie Lozano, Matthew L. Malloy, Pablo Meyer, Shakir Mohamed, Alexandru Niculescu-Mizil, Robert D. Nowak, Jean-Marc Odobez, Peter M. Rasmussen, Irina Rish, Saharon Rosset, Martin Slawski, Stephen C. Strother, Jagannadan Varadarajan, Eric P. Xing
A 12-bit 300-MS/s SAR ADC With Inverter-Based Preamplifier and Common-Mode-Regulation DAC in 14-nm CMOS FinFET (2018)

A single-channel 12-bit SAR ADC achieving 250–340 MS/s and consuming 4.8–8.0 mW from 0.75 to 0.9 V is presented. At 300 MS/s, the ADC exhibits 61.6-dB peak SNDR and reaches 60.5-dB SNDR and 78.7-dB SFDR with 0.8- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text{V}_{\text {pp, diff}}$ </tex-math></inline-formula> input amplitude at Nyquist. It consumes 7.0 mW from a single 0.85-V supply, where 3.7 mW is contributed by the reference buffer. The key element is a comparator with an inverter-based preamplifier to achieve low-noise performance with below 1- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text{V}_{\text {pp, diff}}$ </tex-math></inline-formula> input amplitude. The common-mode (CM) sensitivity of the inverter is counteracted by an SAR-based CM regulation (CMREG). The regulation adjusts the sampled CM to the optimal CM for the maximum inverter gain using a second capacitive DAC. It adjusts the CM on a sample-by-sample basis and, thus, can correct time-varying CM. The implemented CMREG maintains SNDR above 60 dB for a differential input amplitude mismatch of up to 2 dB or a phase mismatch of up to 15°.
Nucleic Acid Sensor with Fluid Handling Components for the Detection of Salmonella enterica (2007)

An embedded controller with a keypad user interface was used to operate a nucleic acid sensor with fluid handling and real-time polymerase chain reaction (PCR) capabilities. The sensor system consisted of pumps and valves for fluid transfer, a fluorometer composed of an LED, photodiode and signal conditioning circuitry, a thermoelectric module (TEM) for heating and cooling the reaction chamber, and power switching circuitry. The amplification and dissociation results of the SYBR Green real-time PCR test can be downloaded to a PC for evaluation.
MITTS (2016)

Memory bandwidth severely limits the scalability and performance of multicore and manycore systems. Application performance can be very sensitive to both the delivered memory bandwidth and latency. In multicore systems, a memory channel is usually shared by multiple cores. Having the ability to precisely provision, schedule, and isolate memory bandwidth and latency on a per-core basis is particularly important when different memory guarantees are needed on a per-customer, per-application, or per-core basis. Infrastructure as a Service (IaaS) Cloud systems, and even general purpose multicores optimized for application throughput or fairness all benefit from the ability to control and schedule memory access on a fine-grain basis. In this paper, we propose MITTS (Memory Inter-arrival Time Traffic Shaping), a simple, distributed hardware mechanism which limits memory traffic at the source (Core or LLC). MITTS shapes memory traffic based on memory request inter-arrival time, enabling fine-grain bandwidth allocation. In an IaaS system, MITTS enables Cloud customers to express their memory distribution needs and pay commensurately. For instance, MITTS enables charging customers that have bursty memory traffic more than customers with uniform memory traffic for the same aggregate bandwidth. Beyond IaaS systems, MITTS can also be used to optimize for throughput or fairness in a general purpose multi-program workload. MITTS uses an online genetic algorithm to configure hardware bins, which can adapt for program phases and variable input sets. We have implemented MITTS in Verilog and have taped-out the design in a 25-core 32nm processor and find that MITTS requires less than 0.9% of core area. We evaluate across SPECint, PARSEC, Apache, and bhm Mail Server workloads, and find that MITTS achieves an average 1.18× performance gain compared to the best static bandwidth allocation, a 2.69× average performance/cost advantage in an IaaS setting, and up to 1.17× better throughput and 1.52× better fairness when compared to conventional memory bandwidth provisioning techniques.
Smart design of patient-centric long-acting products: from preclinical to marketed pipeline trends and opportunities (2022)

Emerging trends are expected to change the field of long-acting products in the upcoming years by increasing capability in engineered molecules (low solubility, long half-life, high potency, etc.), directly developing DP as long-acting oral/injectable, increasing the proportion of products for local drug delivery, and a direction toward more subcutaneous, self-administered products. Among long-acting injectable products, nanosuspensions show a superiority in dose per administration and dosing interval, overwhelming the field of infectious diseases with the recently marketed products.
?-Azido acids for direct use in solid-phase peptide synthesis (2000)

Several new alpha-azido acids have been synthesized and their use in solid-phase peptide synthesis has been demonstrated. The azido group allows for high activation of the carboxyl group as an acid chloride without formation of byproducts and with no detectable racemization. An analog of Leu-enkephalin has been prepared and tested in the mouse vas deferens and guinea pig ileum bioassays: it displays moderate activity at the delta-opiod receptor.
52.3: 2.2 Inch qqVGA AMOLED Driven by Si TFT with Active Layer Deposited at Room Temperature (2007)

Abstract We have successfully fabricated 2.2inch AMOLED display using Si TFT with Si channel formed at room temperature (R.T.). The Si channel layer was deposited by ICP CVD at room temperature. Our R.T. Si TFT showed a field‐effect mobility of 0.07cm 2 /Vsec, 6 V of threshold voltage, 2.2 pA of off current, and 1E6 of on‐off ratio. Based on these performances, active matrix backplane was fabricated with Si TFT with a conventional pixel circuit consisting of 2 TFTs and 1 capacitance.
Fall-related events in people who are lower limb prosthesis users: the lived experience (2021)

Consideration for where LLP users fall, what they are doing when they fall, how they fall, what occurs as a result of a fall, and how well memory of a fall persists may enhance recording and reporting of falls, contribute to development of improved fall risk assessment tools, and inspire the design and function of prosthetic componentry for patient safety.Implications for rehabilitationFalls are a common problem in lower limb prosthesis (LLP) users that can lead to adverse health outcomes.Concerns over near falls, not just falls, may merit greater attention from rehabilitation professionals.Elements of the lived experience that appear unique to LLP users include the role of prosthetic fit, function, and comfort in losing and/or recovering balance; as well as the tendency of LLP users to modify rather than stop or avoid activities associated with falls.
Body-Supported Medical Robots: A Survey (2004)

In medical robotics applications it is often advantageous for a robot to be directly mounted on or supported by the body of the patient during a medical procedure or examination. Whereas early medical robot systems were generally manipulator arms with a large base resting on the floor or mounted to the table next to the patient, several more recently developed systems rest directly on the patient. Body-supported medical robots can be designed to be much more compact and lightweight, leading to improved accuracy and safety and reduced cost, and are easier to set up and use in the operating room environment compared to conventional robot manipulator arms. Five examples of body-supported surgical robots are surveyed in this paper: The ARTHROBOT for total hip arthroplasty, PRAXITELES for knee arthroplasty, MARS for spinal pedicle screw placement and drill guiding, TER for remote ultrasound examinations, and LER for endoscope positioning in minimally invasive surgery.