gebhart/patrepeval huggingface dataset:
LATE-BREAKING ABSTRACT: Novel inhaled ROR/c inhibitor for potential treatment of COPD (2015)

<b>Background:</b> Antibody mediated IL-17 blockade is remarkably successful in autoimmune disease treatment. Recent studies implicate IL-17 in airway diseases. Increased IL-17 immuno-reactivity and Th17 cells in lung tissue and IL-17 level in bronchoalveolar lavage fluid (BALF) is reported in human COPD patients and tobacco-smoke-exposed rats. Anti-IL-17 Ab attenuates airway inflammation in these animals. In human COPD patients, lung IL-17 immuno-reactivity correlates with disease severity. Recent studies also implicate IL-17 in COPD exacerbations. Hence IL-17 blockade seems a very attractive approach in potentially addressing the anti-inflammatory treatment gap in COPD management. IL-17 production is modulated by RORγt / RORc receptor in mice / man and offers a novel mechanism for IL-17 blockade. <b>Objective:</b> We synthesized several novel, potent, selective RORc blockers and evaluated efficacy of the series lead called “Compound A” in animal model of COPD. <b>Results:</b> Compound A is highly selective and potent preclinical lead with IC<sub>50</sub> ofless than 40 nM in RORc binding and PBMC- IL-17 release assay. In vivo, it produced ∼ 75 % inhibition of IL-17 release induced by LPS and anti-CD3. Its efficacy in a COPD was evaluated in cigarette smoke mouse model under acute (7 days) and chronic (3 months) conditions. Compound A showed promising efficacy in suppressing lung cellular infiltration by 50-70% upon intranasal administration. In chronic model, the compound showed significant decrease of lung emphysema, epithelial IL-17 immuno-reactivity and RORgt/IL-17 positive lung cells. <b>Conclusion:</b> Our RORc antagonist is a novel, inhalable IL-17 blocker for potential treatment of COPD.
Coding Tactile Symbols for Phonemic Communication (2018)

We present a study to examine one's learning and processing capacity of broadband tactile information, such as that derived from speech. In Study 1, we tested a user's capability to recognize tactile locations and movements on the forearm in the presence of masking stimuli and determined 9 distinguishable tactile symbols. We associated these symbols to 9 phonemes using two approaches, random and articulation associations. Study 2 showed that novice participants can learn both associations. However, performance for retention, construction of words and knowledge transfer to recognize unlearned words was better with articulation association. In study 3, we trained novel participants to directly recognize words before learning phonemes. Our results show that novel users can retain and generalize the knowledge to recognize new words faster when they were directly train on words. Finally, Study 4 examined optimal presentation rate for the tactile symbols without compromising learning and recognition rate.
Combustion behaviour of ethylene vinyl acetate copolymer‐based intumescent formulations using oxygen consumption calorimetry (1998)

This work compares the fire degradation of ethylene-vinyl acetate 8% copolymer (EVA8) with two flame-retarded formulations, using the cone calorimeter. The first one, EVA8/ammonium polyphosphate (APP) leads to the protection of the material, in the conditions of a fire, by means of blowing up and weak carbonization. The addition of polyamide-6 (PA-6) in EVA8/APP improves the protection by forming an intumescent carbonaceous shield. The fire hazard of the virgin polymer and of the FR systems are quantified, in terms of rate of heat release, weight loss, effective heat of combustion, volume of smoke production and CO and CO2 production. It assesses the effectiveness of the fire retardant additives APP and APP/PA-6 in EVA8-based materials under simulated real fire test conditions. The respective temperatures of the degradation front are deduced from the weight loss data recorded in the course of the cone calorimeter experiments and the results of the invariant kinetic parameters method applied to the different specimens. The addition of APP/PA-6 in EVA8 leads to a superficial phenomenon; the degradation zone is thus located on the upper volume of the specimen during all the exposure to the heat flux. © 1998 John Wiley & Sons, Ltd.
An efficient route to bispecific antibody production using single-reactor mammalian co-culture (2016)

Bispecific antibodies have shown promise in the clinic as medicines with novel mechanisms of action. Lack of efficient production of bispecific IgGs, however, has limited their rapid advancement. Here, we describe a single-reactor process using mammalian cell co-culture production to efficiently produce a bispecific IgG with 4 distinct polypeptide chains without the need for parallel processing of each half-antibody or additional framework mutations. This method resembles a conventional process, and the quality and yield of the monoclonal antibodies are equal to those produced using parallel processing methods. We demonstrate the application of the approach to diverse bispecific antibodies, and its suitability for production of a tissue specific molecule targeting fibroblast growth factor receptor 1 and klotho β that is being developed for type 2 diabetes and other obesity-linked disorders.
Electrodeposition of Gold (2010)

This chapter contains sections titled: Typical Direct Current (DC) Plating Baths Mechanism of Deposition Pulse Plating Substrate Preparation Stains Test Methods References
Low Dk and Df Photosensitive Insulation Material for Low Transmission Loss Packages (2018)

Abstract The interposer or fan-out packaging technology with ultra-fine line/space and high frequency signal has been required in order to achieve high speed interconnection between chips with low cost. In this paper, we have newly developed low Dk and Df photosensitive insulation material. The additional features of the developed materials are very low moisture absorptivity less than 0.3 wt%, low anion impurities and high resistance to hydrolysis. The micro-strip line was fabricated to evaluate the influence of developed material. The insertion loss from transmission lines on Material C shows much lower loss than the conventional reference material at higher frequencies. The peel strength to the sputtered Ti and Cu is over 0.7 kN/m. The material also demonstrated SAP fabrication compatibility with fine circuitry and passed insulation reliability by biased-HAST showing no copper migration measured by EDX.
Contact-based in-hand pose estimation using Bayesian state estimation and particle filtering (2020)

In industrial assembly tasks, the position of an object grasped by the robot has to be known with high precision in order to insert or place it. In real applications, this problem is commonly solved by jigs that are specially produced for each part. However, they significantly limit flexibility and are prohibitive when the target parts change often, so a flexible method to localize parts with high accuracy after grasping is desired. To solve this problem, we propose a method that can estimate the position of an object in the robot's hand to sub-millimeter precision, and can improve its estimate incrementally, using only minimal calibration and a force sensor. Our method is applicable to any robotic gripper and any rigid object that the gripper can hold, and requires only a force sensor. We demonstrate that the method can determine the position of an object to a precision of under 1 mm without using any part-specific jigs or equipment.
Proper functioning of the Xeroderma Pigmentosum group A protein is dependent on interaction with PCNA (2011)

Proper functioning of the Xeroderma Pigmentosum group A protein is dependent on interaction with PCNA
Hierarchical Reinforcement Learning with AI Planning Models (2022)

Two common approaches to sequential decision-making are AI planning (AIP) and reinforcement learning (RL). Each has strengths and weaknesses. AIP is interpretable, easy to integrate with symbolic knowledge, and often efficient, but requires an up-front logical domain specification and is sensitive to noise; RL only requires specification of rewards and is robust to noise but is sample inefficient and not easily supplied with external knowledge. We propose an integrative approach that combines high-level planning with RL, retaining interpretability, transfer, and efficiency, while allowing for robust learning of the lower-level plan actions. Our approach defines options in hierarchical reinforcement learning (HRL) from AIP operators by establishing a correspondence between the state transition model of AI planning problem and the abstract state transition system of a Markov Decision Process (MDP). Options are learned by adding intrinsic rewards to encourage consistency between the MDP and AIP transition models. We demonstrate the benefit of our integrated approach by comparing the performance of RL and HRL algorithms in both MiniGrid and N-rooms environments, showing the advantage of our method over the existing ones.
Erratum: “Real-time/in situ diffraction study of phase and microstructural evolution in sputtered β-Ta/Ta2O5 films” [J. Vac. Sci. Technol. A 19, 2910 (2001)] (2002)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. F. Whitacre, S. M. Yalisove, J. C. Bilello; Erratum: "Real-time/in situ diffraction study of phase and microstructural evolution in sputtered β-Ta/Ta2O5 films" [J. Vac. Sci. Technol. A 19, 2910 (2001)]. Journal of Vacuum Science & Technology A 1 July 2002; 20 (4): 1505. https://doi.org/10.1116/1.1477419 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science & Technology A Search Advanced Search |Citation Search
Modeling of Iron Losses of Electrical Machines and Transformers Fed by PWM Inverters (2007)

With the development of power electronic techniques, pulse-width modulated (PWM) inverters are widely used to control electrical machines, to feed transformers and to interface renewable energy systems. There are abundant high frequency harmonics in the output voltage of a PWM inverter, which increase the iron loss and result in a de-rating of the machine or transformer. Predicting the iron losses caused by the PWM voltage is very important for the design of electrical machines and transformers fed by PWM inverters. Eddy current loss is the main part of the iron loss caused by PWM. In this paper, after analyzing the harmonic components of PWM voltage, the effects of different parameters of PWM on the eddy current loss are derived. The relationship of eddy current losses with switching frequency and amplitude modulation ratio is considered. The iron losses modeled with the proposed analytical methods of a single phase transformer are compared with results of time-stepping finite element analysis to gain confidence. The relationship of duty cycle and eddy current loss of PWM supplied DC motors is also studied in this paper.
Jointly Leveraging Decorrelation and Sparsity for Improved Feedback Cancellation in Hearing Aids (2020)

We propose a new adaptive feedback cancellation (AFC) system in hearing aids (HAs) based on a well-posed optimization criterion that jointly considers both decorrelation of the signals and sparsity of the underlying channel. We show that the least squares criterion on subband errors regularized by a <i>p</i>-norm-like diversity measure can be used to simultaneously decorrelate the speech signals and exploit sparsity of the acoustic feedback path impulse response. Compared with traditional subband adaptive filters that are not appropriate for incorporating sparsity due to shorter sub-filters, our proposed framework is suitable for promoting sparse characteristics, as the update rule utilizing subband information actually operates in the fullband. Simulation results show that the normalized misalignment, added stable gain, and other objective metrics of the AFC are significantly improved by choosing a proper sparsity promoting factor and a suitable number of subbands. More importantly, the results indicate that the benefits of subband decomposition and sparsity promoting are complementary and additive for AFC in HAs.
ABS-maleated SEBS blend as a 3D printable material (2016)

A key enabler for the advancement of material extrusion 3D printing is the implementation of new printable materials with a wide variety of physical properties. The focus of this study is the development of 3D printable polymer blends based on compounding acrylonitrile butadiene styrene (ABS) with styrene ethylene butylene styrene. Here the mechanical properties of the resulting novel material systems were manipulated through the change of mixture composition. The novel blends were evaluated based on mechanical testing and fracture surface analysis. Additionally, the rheological characteristics were determined based on melt flow index values. Key results were the significant increase in elongation at break values from 8.53% (ABS baseline) to 1506.57% (rubberised ABS) and the drastic difference in fracture surface morphology when comparing the various blends to ABS.
Direct Catalytic Enantioselective α‐Aminoxylation of Ketones: A Stereoselective Synthesis of α‐Hydroxy and α,α′‐Dihydroxy Ketones (2004)

Prolin-katalysierte Reaktionen von unmodifizierten Ketonen mit Nitrosobenzol führen mit ausgezeichneten Diastereo- und Enantioselektivitäten zu geschützten α-Hydroxy- und α,α′-Dihydroxyketonen [Gl. (1)], die essenzielle Bausteine in der Naturstoffsynthese sind.
Super-high Strength Low Alloy Steel OCTG with Improved Sour Resistance (2015)

Material design concepts and the applicability of 125ksi (862MPa) grade super-high strength low alloy steel OCTG (oil country tubular goods) for sour service are described in this paper. Following metallurgical techniques were necessary for enhancing sour (SSC) resistance - prevention of pitting by minimizing inclusion size, decrease in dislocation density by high temperature tempering using nano-sized carbides, and improvements of carbides morphologies at grain boundaries - spheroidizing M 3 C and preventing M 23 C 6 formation. The developed steel showed superior SSC resistance to conventional steels on the H 2 S-pH domain map. The 125ksi sour grade OCTG was commercialized in 2003, the first material of that kind in the world. This new OCTG has been used in deep gas wells in the UK and Norwegian North Sea, and the Caspian Sea.
Room-Temperature Quantum Bit Memory Exceeding One Second (2012)

Stable quantum bits, capable both of storing quantum information for macroscopic time scales and of integration inside small portable devices, are an essential building block for an array of potential applications. We demonstrate high-fidelity control of a solid-state qubit, which preserves its polarization for several minutes and features coherence lifetimes exceeding 1 second at room temperature. The qubit consists of a single (13)C nuclear spin in the vicinity of a nitrogen-vacancy color center within an isotopically purified diamond crystal. The long qubit memory time was achieved via a technique involving dissipative decoupling of the single nuclear spin from its local environment. The versatility, robustness, and potential scalability of this system may allow for new applications in quantum information science.
Towards Deterministic Communications in 6G Networks: State of the Art, Open Challenges and the Way Forward (2023)

Over the last decade, society and industries are undergoing rapid digitization that is expected to lead to the evolution of the cyber-physical continuum. End-to-end deterministic communications infrastructure is the essential glue that will bridge the digital and physical worlds of the continuum. We describe the state of the art and open challenges with respect to contemporary deterministic communications and compute technologies: 3GPP 5G, IEEE Time-Sensitive Networking, IETF DetNet, OPC UA as well as edge computing. While these technologies represent significant technological advancements towards networking Cyber-Physical Systems (CPS), we argue in this paper that they rather represent a first generation of systems which are still limited in different dimensions. In contrast, realizing future deterministic communication systems requires, firstly, seamless convergence between these technologies and, secondly, scalability to support heterogeneous (time-varying requirements) arising from diverse CPS applications. In addition, future deterministic communication networks will have to provide such characteristics end-to-end, which for CPS refers to the entire communication and computation loop, from sensors to actuators. In this paper, we discuss the state of the art regarding the main challenges towards these goals: predictability, end-to-end technology integration, end-to-end security, and scalable vertical application interfacing. We then present our vision regarding viable approaches and technological enablers to overcome these four central challenges. Key approaches to leverage in that regard are 6G system evolutions, wireless friendly integration of 6G into TSN and DetNet, novel end-to-end security approaches, efficient edge-cloud integrations, data-driven approaches for stochastic characterization and prediction, as well as leveraging digital twins towards system awareness.
Strong nuclear contribution to the optical Kerr effect in niobium oxide containing glasses (2007)

The electronic and nuclear contributions to nonlinear optical properties of niobium oxide-based glasses have been measured using third-harmonic generation and pump-probe techniques. The results have been found to be in agreement with Hellwarth's model for niobium oxide $({\mathrm{Nb}}_{2}{\mathrm{O}}_{5})$ concentrations below $30\phantom{\rule{0.3em}{0ex}}\mathrm{mol}\phantom{\rule{0.2em}{0ex}}%$. Above $30\phantom{\rule{0.3em}{0ex}}\mathrm{mol}\phantom{\rule{0.2em}{0ex}}%$ ${\mathrm{Nb}}_{2}{\mathrm{O}}_{5}$, discrepancies with the theoretical model have been observed. It has been found that high niobium ion content induces a change of the local structure within the glass and favors the formation of three-dimensional blocks of corner-sharing ${\mathrm{NbO}}_{6}$ octahedra. Since similarities with crystalline structures are present, we propose that some specific collective vibrational modes could be at the origin of the extra nuclear contributions to the optical Kerr effect.
Engaging Aldehydes in CuH-Catalyzed Reductive Coupling Reactions: Stereoselective Allylation from 1,3-Diene Pronucleophiles (2019)

Recently, CuH-catalyzed reductive coupling processes involving carbonyl compounds and imines has become an attractive alternative to traditional methods for stereoselective addition to carbonyls due to the ability to use readily accessible and stable olefin-derived pronucleophiles as surrogates for organometallic reagents. However, the inability to use aldehydes, which traditionally reduce too rapidly in the presence of copper hydride complexes to be viable substrates, has been a major limitation. We show that by exploiting relative concentration effects through slow addition, we can invert this intrinsic reactivity and achieve the reductive coupling of 1,3-dienes with aldehydes. Using this method, both aromatic and aliphatic aldehydes can be transformed to valuable products with high levels of diastereo- and enantioselectivity and in the presence of many useful functional groups. Furthermore, using a combination of theoretical (DFT) and experimental methods, important mechanistic features of this reaction related to stereo- and chemoselectivity were uncovered.
Sound‐Structure Interaction Fundamentals (2016)

This chapter demonstrates what structural vibrations do to neighboring acoustic fluids, and what sound fields do to neighboring structures. The overarching concept of linear sound-structure interaction is simple: the normal particle velocity in the structure and fluid along the fluid-structure interaction boundary must be the same. This means that when a structure vibrates against a fluid, the component of the vibration normal to the structural surface must be identical to the corresponding particle velocity in the neighboring fluid. The chapter starts by examining how a structure's vibrations compress and expand a neighboring fluid. Next, it shows how two important structures, a circular baffled piston and a flat rectangular flexible finite plate, eradiate sound, and are fluid-loaded by the impedance of the surrounding acoustic fluid. Finally, the chapter considers the complementary problem of how acoustic waves induce vibration in a structure.
PV inverter simulation using MATLAB/Simulink graphical environment and PLECS blockset (2006)

In this paper a photovoltaic (PV) energy conversion system is simulated jointly with its control. The simulation of the system is developed for testing control algorithm before a real-time implementation. The control part is developed using MATLAB/Simulink in order to ensure a direct generation of the real-time code for the dSPACE control board. The simulation of the power system is first realized using MATLAB/Simulink. In a second step, the simulation of the power system is realized using the PLECS toolbox. Both simulation models are tested and selective simulation results are provided for a comparative study
Two-phase flow instability analysis for transient electronics cooling (2010)

Because of increasing power densities, refrigeration systems are being explored for two-phase cooling of ultra high power electronic components. This paper presents a framework for the transient analysis of pressure-drop refrigerant flow instabilities under both steady-state and transient imposed heat loads. Based on an analytical two-phase flow model, the system pressure and other effects on flow characteristics are quantitatively studied, so as to predict the associated flow instability margin. The most significant effect on electronics cooling system dynamics is the imposed heat load. One of the main research topics here is to study the boiling oscillatory flow responses to transient heat load changes, which can reflect the transient two-phase cooling capacity. Furthermore, the effect of wall thermal inertia on flow oscillation is systematically studied. Application-based pulsed heat load scenarios are finally evaluated. This transient instability analysis offers useful insight for future active thermal management system design.
3D photonic bandgap templating using holography and direct laser writing (2005)

We review our work on fabricating templates for photonic band gap materials at telecommunication wavelengths via holography and direct laser writing. Measured optical spectra are compared with theory, revealing the excellent quality of these structures.
OTR interferometry diagnostic for the A0 Photoinjector (2007)

OTR interferometry (OTRI) is an attractive diagnostic for investigation of relativistic electron beam parameters. The diagnostic is currently under development at the A0 Photoinjector. This diagnostic is also applicable for NML accelerator test facility that will be built at Fermilab. The experimental setup of the OTR Interferometer for the FNAL A0 Photoinjector is described in the report. Results of simulations and measurements are presented and discussed.