gebhart/patrepeval huggingface dataset:
The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations (2018)

Etomoxir (ETO) is a widely used small-molecule inhibitor of fatty acid oxidation (FAO) through its irreversible inhibitory effects on the carnitine palmitoyl-transferase 1a (CPT1a). We used this compound to evaluate the role of fatty acid oxidation in rapidly proliferating T cells following costimulation through the CD28 receptor. We show that ETO has a moderate effect on T cell proliferation with no observable effect on memory differentiation, but a marked effect on oxidative metabolism. We show that this oxidative metabolism is primarily dependent upon glutamine rather than FAO. Using an shRNA approach to reduce CPT1a in T cells, we further demonstrate that the inhibition of oxidative metabolism in T cells by ETO is independent of its effects on FAO at concentrations exceeding 5 μM. Concentrations of ETO above 5 μM induce acute production of ROS with associated evidence of severe oxidative stress in proliferating T cells. In aggregate, these data indicate that ETO lacks specificity for CTP1a above 5 μM, and caution should be used when employing this compound for studies in cells due to its non-specific effects on oxidative metabolism and cellular redox.
Functional expression of TRAIL by lymphoid and myeloid tumour cells (1999)

TRAIL is a potent death protein that favours the killing of various types of cancer cells to normal cells, but under the right conditions TRAIL can also kill activated human T cells. TRAIL mRNA is widely expressed by normal cells but its expression by primary tumour cells is not known. In this study, primary tumour cells of haemopoietic origin constitutively expressed TRAIL mRNA and protein and were capable of inducing the apoptosis of target Jurkat cells in a dose-dependent manner. This killing effect was reversed by anti-TRAIL antibody. The functional expression of TRAIL by lymphoid and myeloid malignant cells raises the possibility of its involvement in tumour cell evasion of immunosurveillance, and could be related to spontaneous tumour cell death and necrosis.
Erbium-based plasmonic-assisted vertical emitter (2011)

Erbium-based plasmonic-assisted vertical emitters at telecommunication wavelengths have been investigated. We show that net gain and array of lasers are achievable.
NVDL-Cache: Narrow-Width Value Aware Variable Delay Low-Power Data Cache (2019)

Cache memories dissipate a large portion of processors' power budget. On the other hand, due to unbalanced stress condition on their SRAMs, aging of cache memories is one of the most challenging reliability issues in modern processors. Therefore, power management and aging mitigation of these memories are mandatory in recent nanoscale technologies to achieve reliable and stable functionality of processor. Regarding the fact that the rate of Narrow-Width Values (NWVs) stored in data-caches memory is more than 80%, this work proposes an NWV-aware power consumption reduction and aging mitigation technique. In the proposed data-cache memory, the operating voltage of memory blocks which store the most significant bits of cache words is adjustable according to the rate of NWVs to reduce cache power consumption and aging rate. Our simulations show the proposed technique decreases the overall power dissipation of a 32KB cache memory by 44.20%, with 0.55% and 2.4% performance and area overheads, respectively. This technique prolongs the lifetime of the cache by up to 1.96x.
Periostin levels correlate with disease severity and chronicity in patients with atopic dermatitis (2014)

Periostin may play a critical role in disease severity and chronicity in the pathogenesis of AD.
Color and pulsed Doppler signatures of vascular bleeding (2006)

To develop ultrasound-based methods for detection and localization of internal vascular bleeding, we investigated the bleeding signatures using color and pulsed Doppler. Under ultrasound guidance, femoral arteries (n=13) and veins (n=12) in seven pigs were catheterized with 6, 9, and 11 F catheters. Color and pulsed Doppler were acquired from the injury site and the surrounding positions after withdrawal of the catheter. The bleeding rates were 3.8–38 ml/s. Color Doppler revealed that the injured vessels were in spasm. The checkered color pattern at the injury site indicated flow turbulence. Pulsed Doppler spectrum of the color jet (extravasated blood) represented a unique arterial bleeding pattern with increased baseline velocity (from 0 up to 25.8 cm/s) and elevated systolic velocity (from 23.2 up to 62.5 cm/s) at the puncture site, as compared to the normal arterial pattern. Venous bleeding showed a narrow-band vibration signal at the bleeding site. Local blood turbulence contained multiple velocity components which were illustrated as checkered color in color Doppler. Pulsed Doppler spectrum showed increased baseline due to turbulence and elevated velocity due to narrowed vessel. In future studies pulsed Doppler radio-frequency data will be used to analyze bleeding patterns for detection and localization of internal bleeding.
Chiralitätsverstärkung in dynamischen supramolekularen Aggregaten (2007)

Abstract Die Frage nach dem Ursprung der Chiralität in biologischen Systemen löste die Suche nach nichtlinearen Effekten in der Katalyse aus, und man suchte nach Wegen, um ausgehend von minimalen Enantiomerenüberschüssen optisch reine Verbindungen zu erhalten. Intensiv erforscht wurde bereits die Chiralitätsverstärkung in Polymeren als Folge kooperativer Prozesse. Vor zehn Jahren wurde dieser Effekt erstmals auch für nichtkovalente, dynamische supramolekulare Systeme nachgewiesen. Seitdem hat sich gezeigt, dass auch für niedermolekulare Verbindungen eine Chiralitätsverstärkung möglich ist, wenn nichtkovalente Wechselwirkungen wie Wasserstoffbrücken, hydrophobe und π‐π‐Stapelwechselwirkungen aufeinander abgestimmt werden. Wir fassen die Resultate der letzten zehn Jahre zusammen und leiten daraus einige allgemeine Regeln ab. Eine Chiralitätsverstärkung kann zwar immer noch nicht sicher vorhergesagt werden, essenziell sind aber wohl ein ausgewogenes Verhältnis der beteiligten Wechselwirkungen und oftmals die Bildung eines intrinsisch chiralen Objekts sowie kooperative Aggregationsprozesse.
Smart Grid reliability assessment utilizing Boolean Driven Markov Process and variable weather conditions (2015)

The transition from conventional electric grid to a more environmentally-friendly, reliable and efficient grid necessitates the reliability improvement. This will play an indispensable role in the future power system called Smart Grid (SG) due to the digital power supply requirements. This distinctive study demonstrates a combined effect of weather conditions and distributed generations (DGs) on the availability of the power system in a region. The ability to model the dynamics of the SG including the variation of weather conditions at different locations for the large-scale system is formulated. In this effort a novel approach is proposed based on the Variable Weather Boolean Logic Driven Markov Process (VW-BDMP), which is utilized along with statistical data. The major contribution of this paper is to introduce a method for the SG reliability assessment (SGRA) considering variable weather conditions, which provides an advantageous tool for the future power system reliability studies.
Sensitive detection of Interleukin-6 (IL-6) on the plasmonic chip by Grating Coupled-Surface Plasmon-field enhanced Fluorescence Imaging (2013)

As for a sensitive immunosensor, we focused on the Surface Plasmon-field enhanced Fluorescence Spectroscopy (SPFS) based on the Surface Plasmon Resonance (SPR) in some powerful techniques. Recently, we have sensitively detected analytes with Grating Coupled-Surface Plasmon-field enhanced Fluorescence Imaging (GC-SPFI). In this study, Interleukin-6 (IL-6), which acts as both pro-inflammatory and anti-inflammatory cytokine, was detected on the plasmonic chip by the GC-SPFI instrument. IL-6 was quantitatively evaluated at low concentration due to the effect of fluorescence enhancement.
Electron-transfer chemistry of electronically excited octachlorodirhenate(III) (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron-transfer chemistry of electronically excited octachlorodirhenate(III)Daniel G. Nocera and Harry B. GrayCite this: Inorg. Chem. 1984, 23, 23, 3686–3688Publication Date (Print):November 1, 1984Publication History Published online1 May 2002Published inissue 1 November 1984https://pubs.acs.org/doi/10.1021/ic00191a003https://doi.org/10.1021/ic00191a003research-articleACS PublicationsRequest reuse permissionsArticle Views163Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Zinc-binding Site of Escherichia coli Glutamyl-tRNA Synthetase Is Located in the Acceptor-binding Domain (1995)

The zinc contents of fragments of Escherichia coli glutamyl-tRNA synthetase, as well as the conservation of the CYC sequence only in zinc-containing glutamyl-tRNA synthetases, suggested that the 98CYCX24-CRHSHEHHADDEPC138 includes some or all residues involved in binding its zinc atom (Liu, J., Lin, S.-X., Blochet, J.-E., Pézolet, M., and Lapointe, J. (1993) Biochemistry 32, 11390-11396). Extended x-ray absorption fine structure (EXAFS) shows that this zinc atom has a four-coordinate non-planar coordination environment with 3 sulfur and 1 nitrogen atoms with bond lengths, respectively, 2.37 +/- 0.02 A and 2.01 +/- 0.02 A, presumably belonging to 3 cysteine residues and 1 histidine residue. Conservative replacement of each histidine and cysteine residue of the 98C-138C segment, respectively, with glutamine (Q) and serine (S), yields variants H129Q, H131Q, H132Q, and C138S (which sustain the growth at 42 degrees C of E. coli JP1449, whose glutamyl-tRNA synthetase is thermosensitive) and C98S, C100S, C125S, and H127Q (which do not). The amount of this enzyme in these mutants is at least 1 order of magnitude larger than that in a wild type strain; however, no glutamyl-tRNA synthetase activity is detectable in extracts of the variants C100S and C125S, whereas its specific activity in those of C98S and H127Q is about 10-fold lower than in cells overproducing the wild type enzyme or the variants H129Q, H131Q, H132Q, and C138S. These results indicate that the zinc atom present in E. coli glutamyl-tRNA synthetase is bound by the 2 evolutionarily conserved cysteines at positions 98 and 100, and by Cys125 and His127. Molecular modeling of the N-terminal half of this enzyme, using the known structure of E. coli glutaminyl-tRNA synthetase, supports this conclusion and suggests that the 98C-127H segment does not have the characteristics of the classical zinc fingers.
Local anesthetic with sedation is a viable alternative to general anesthesia for lumbar spinal decompressions: A retrospective cohort feasibility study and short-term analysis of outcomes (2020)

Background: An increasing focus on value-based care in spine surgery has prompted interest in alternative anesthetics. Avoidance of general anesthesia (GA) has gained support due to reductions in postoperative symptoms. Little has been published on local anesthesia with sedation techniques. Methods: A retrospective chart review was performed to compare outcomes of lumbar decompression using local anesthesia with light intravenous sedative (LIS) and lumbar decompression using general anesthesia. Outcomes reported were 90-day adverse events, reoperations, and narcotic use. Results: A total of 65 patients who underwent lumbar decompression were identified. Patients receiving LIS were older and had more comorbidities compared with those receiving GA. Rates of peripheral vascular disease and peptic ulcer disease were higher in patients receiving LIS ( P =0.004 and 0.012, respectively). The overall rate of postoperative adverse events was 30% lower in patients with LIS. There were no aborted procedures in the LIS cohort. Rates of reoperation trended towards being lower in LIS (14.3%) versus the GA group (37.8%). There was no difference in postoperative narcotic use (LIS 17.9%, GA 24.3%, P =0.530). After adjusting for age, gender, body mass index, Charlson Comorbidity Index, and peripheral vascular disease, the rate of adverse events remained lower in the LIS group (odds ratio: 0.166 [95% CI: 0.037, 0.617], P =0.011), and the trends towards lower rates of recurrent stenosis ( P =0.082) and reoperation ( P =0.082) remained. There was still no difference in the rate of postoperative narcotic use beyond the first follow-up ( P =0.542). Conclusions: Lumbar spinal decompressions are commonly performed surgeries, and they are increasingly being performed in outpatient settings. We conclude that LIS is a safe alternative to GA. Further work is needed to identify cost savings in LIS spine surgery and define patient characteristics that identify appropriate candidates. Level of Evidence: Level III.
Inverted Pendulum-Robot for Ubiquitous Assistant (2003)

ユビキタス社会にロボットがどのように適用できるかを研究した, 具体的には転倒せずに人に追従し, その頭部には PDA を搭載した倒立振子型のロボットで, 人間のアシストの方法を提唱した。
Flash Fabrication of Orally Targeted Nanocomplexes for Improved Transport of Salmon Calcitonin across the Intestine (2020)

Salmon calcitonin (sCT) is a potent calcium-regulating peptide hormone and widely applied for the treatment of some bone diseases clinically. However, the therapeutic usefulness of sCT is hindered by the frequent injection required, owing to its short plasma half-life and therapeutic need for a high dose. Oral delivery is a popular modality of administration for patients because of its convenience to self-administration and high patient compliance, while orally administered sCT remains a great challenge currently due to the existence of multiple barriers in the gastrointestinal (GI) tract. Here, we introduced an orally targeted delivery system to increase the transport of sCT across the intestine through both the paracellular permeation route and the bile acid pathway. In this system, sCT-based glycol chitosan-taurocholic acid conjugate (GC-T)/dextran sulfate (DS) ternary nanocomplexes (NC-T) were produced by a flash nanocomplexation (FNC) process in a kinetically controlled mode. The optimized NC-T exhibited well-controlled properties with a uniform and sub-60 nm hydrodynamic diameter, high batch-to-batch reproducibility, good physical or chemical stability, as well as sustained drug release behaviors. The studies revealed that NC-T could effectively improve the intestinal uptake and permeability, owing to its surface functionalization with the taurocholic acid ligand. In the rat model, orally administered NC-T showed an obvious hypocalcemia effect and a relative oral bioavailability of 10.9%. An in vivo assay also demonstrated that NC-T induced no observable side effect after long-term oral administration. As a result, the orally targeted nanocomplex might be a promising candidate for improving the oral transport of therapeutic peptides.
Effect of Crystalline Structure of Cd(OH)2 Precursor on the Photocatalytic Activity of Stratified CdS (2007)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation S. Yokoyama, H. Takahashi, Y. Sato, B. Jeyadevan, K. Tohji; Effect of Crystalline Structure of Cd(OH)2 Precursor on the Photocatalytic Activity of Stratified CdS. AIP Conf. Proc. 20 March 2007; 898 (1): 179–181. https://doi.org/10.1063/1.2721275 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
ChemInform Abstract: Palladium‐Catalysed Coupling Reactions (2013)

Abstract Review: 116 refs.
Wavelength Switching with Temperature in Liquid-Crystal-infiltrated Phtonic Crystal Fibers (2007)

본 연구에서는 클래딩 영역에 주기적인 공기층이 있는 광자 결정 광섬유에 액정을 주입하고, 온도를 변화시켜 주면서 빛의 투과 스펙트럼의 변화를 측정하였다. 액정을 주입한 광섬유는 특정 온도에서 특정 파장에 대해 여러 가지 투과특성을 얻어 낼 수 있었다. 광섬유에 가해주는 온도에 따라서 투과하는 광 신호를 약 <TEX>$10\sim15dB$</TEX> 정도 최소화 할 수 있었는데, 이를 이용하면 특정 파장 대역에서 광 신호를 소광시킬 수 있는 광 스위칭 소자에 응용 가능할 것이다. We have measured the optical spectra while varying the temperature of photonic crystal fibers (PCFs) with periodic air holes in the cladding. These are liquid crystal infiltrated fibers. For the liquid crystal infiltrated PCFs, we obtained the transmission of several wavelengths at specific temperatures. The transmission power could be reduced by about <TEX>$10\sim15dB$</TEX> by varying the applied temperature in the liquid crystal PCF. We expect that it is applicable as a wavelength switching device in the specific wavelength band.
Solid-state Architecture Batteries for Enhanced Rechargeability and Safety (SABERS) (2020)

All-electric vertical take-off and landing vehicles (eVTOL) for urban air mobility (UAM) concepts face numerous challenging technical barriers before their introduction into the consumer marketplace. The most challenging of these technical barriers to overcome is developing an energy storage system capable of meeting the rigorous aerospace safety and performance criteria. The performance metrics for eVTOL craft, such as specific energy and cycle life, are at least 2 times greater than those of electric automobiles. Furthermore, safety is essential for operation of commercial electric aerovehicles. Preliminary systems level analysis studies have indicated that there are five key properties which must be optimized for successful implementation of battery systems. Those five key criteria are safety, energy density, power, packaging design and scalability. Current state-of-the-art (SOA) lithium-ion batteries meet or exceed the requirements for electric aviation in the areas of power and scalability, yet are insufficient in the key performance criteria of energy, safety and packaging design. 
The SABERS concept proposes a battery that meets all five key performance criteria through the development of a solid-state architecture cell design utilizing high energy density and power density sulfur-selenium cathode with a lithium metal anode. Data will be presented demonstrating high performing sulfur - selenium cathode that offers a balanced energy to power density ratio, which can be tailored to the specific application by altering the stoichiometric ratios of sulfur to selenium. This cathode is being developed by implementing NASA patented holey graphene technology as a highly conductive, ultra-lightweight electrode scaffold. Novel processing methods allow developing solid-state electrolyte that is a safe, non-flammable replacement to the highly flammable liquid organic electrolytes currently used in SOA lithium-ion batteries. The all solid-state lithium-sulfur-selenium cell design enables the implementation of a bipolar stack configuration, which has the advantages of reducing overall cell weight, reducing the amount of interfaced connections for the cell, and minimizing cooling requirements for the battery. In particular, the solid-state design allows for a serial stacking configuration to enable dense packaging of the cells within the bipolar stack. Lastly, optimization of battery components occurs through a robust and rigorous combination of various computational modeling techniques covering multiple length scales. The expected result will be a solid-state battery with operational temperatures from 0 °C to 150 °C which provides the required energy density, discharge rate, and inherent safety to meet strict aerospace performance criteria.
Efficient Learning of Deep Boltzmann Machines (2010)

We present a new approximate inference algorithm for Deep Boltzmann Machines (DBM’s), a generative model with many layers of hidden variables. The algorithm learns a separate “recognition ” model that is used to quickly initialize, in a single bottom-up pass, the values of the latent variables in all hidden layers. We show that using such a recognition model, followed by a combined top-down and bottom-up pass, it is possible to efficiently learn a good generative model of high-dimensional highly-structured sensory input. We show that the additional computations required by incorporating a top-down feedback plays a critical role in the performance of a DBM, both as a generative and discriminative model. Moreover, inference is only at most three times slower compared to the approximate inference in a Deep Belief Network (DBN), making large-scale learning of DBM’s practical. Finally, we demonstrate that the DBM’s trained using the proposed approximate inference algorithm perform well compared to DBN’s and SVM’s on the MNIST handwritten digit, OCR English letters, and NORB visual object recognition tasks. 1
MS analysis reveals O‐methylation of L‐lactate dehydrogenase from pancreatic ductal adenocarcinoma cells (2012)

L-lactate dehydrogenase (LDH) converts pyruvate to lactate when oxygen is absent or in short supply, and the enzyme plays a crucial role in cancer metabolism. The functions of many mammalian proteins are modulated by posttranslational modifications (PTMs), and it has been reported that LDH was subjected to several PTMs, including phosphorylation, acetylation, and methylation. In this present work, we characterized the PTMs of LDH from pancreatic ductal adenocarcinoma (PDAC) cells by electrophoresis and mass spectrometry, and identified 13 O-methylated residues from the enzyme. In addition, our qualitative analysis revealed differential methylation of LDH from normal duct cells. The preliminary findings from this study provide important biochemical information toward further understanding of the LDH modifications and their functional significance in pathophysiological processes of pancreatic cancer.
In Vitro Growth Inhibition of Plant Pathogenic Fungi, Botrytis spp., by Escherichia coli Transformed with a Chitinolytic Enzyme Gene from a Marine Bacterium, Alteromonas sp. Strain 79401. (1996)

Marine bacterium, Alteromonas sp. strain 79401 was shown to suppress the conidial growth of plant pathogenic fungi Botrytis cinerea and B. fabae in vitro by means of its high chitinolytic activity. To use the ability of this bacterium for biocontrol, a DNA fragment (ca. 12kb) carrying the chitinolytic enzyme gene(s) was cloned into the plasmid pBR322. The resulting plasmid, pALCHI1, was introduced into Escherichia coli strain DH5. B. cinerea and B. fabae could not grow in the vicinity of the transformed E. coli colonies in vitro. Conidial germination and hyphal growth were markedly suppressed. Swelling of the conidia and germ tubes and bursting of hyphal tips were observed under a microscope, suggesting that the chitinolytic enzyme affected the fungal cell walls. This chitinolytic enzyme gene might be useful for the biocontrol of Botrytis spp. and other plant pathogenic fungi.