gebhart/patrepeval huggingface dataset:
Where is your dive buddy: tracking humans underwater using spatio-temporal features (2007)

We present an algorithm for underwater robots to track mobile targets, and specifically human divers, by detecting periodic motion. Periodic motion is typically associated with propulsion underwater and specifically with the kicking of human swimmers. By computing local amplitude spectra in a video sequence, we find the location of a diver in the robot's field of view. We use the Fourier transform to extract the responses of varying intensities in the image space over time to detect characteristic low frequency oscillations to identify an undulating flipper motion associated with typical gaits. In case of detecting multiple locations that exhibit large low-frequency energy responses, we combine the gait detector with other methods to eliminate false detections. We present results of our algorithm on open-ocean video footage of swimming divers, and also discuss possible extensions and enhancements of the proposed approach for tracking other objects that exhibit low- frequency oscillatory motion.
Anti-gastric acid secretory mechanism of 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylic acid. Effect on mucosal mast cell. (1996)

To clarify the anti-gastric acid secretory mechanism of 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarbo xylic acid (CAS 98772-05-5, MAR-99), the relationship between gastric acid secretion and gastric mucosal mast cell (MMC) was studied and the effect of this compound on these parameters was examined and compared with anti-allergic drugs (mast cell stabilizers) and anti-ulcer drugs. The release of histamine from MMC cultured from bone marrow and connective tissue mast cell (CTMC) isolated from peritoneal cavity was found to be induced by the addition of ethanol (final conc. 17.5%), and the inhibitory effect on histamine release from MMC is closely associated with the anti-gastric secretory effect. That is to say, MAR-99 (10(-9)-10(-7) mol/l) inhibited histamine release from MMC induced by ethanol in a concentration-dependent manner. The action of MAR-99 on MMC was more sensitive than that of CTMC. In addition, MAR-99 (100 mg/kg i.d.) suppressed gastric acid secretion. On the other hand, anti-allergic drugs (mast cell stabilizers), such as DSCG and tranilast (both 10(-7) mol/l), markedly inhibited histamine release from CTMC induced by ethanol, but these drugs (10(-8)-10(-7) mol/l) showed only a tendency to prevent the release of histamine from MMC. Furthermore these drugs (both 100 mg/ kg i.d.) had no effects on gastric acid secretion. Equally anti-ulcer drugs, such as cetraxate, teprenone and sofalcone, had no effects on histamine release from mast cells of two types and gastric acid secretion. From these results, it was suggested that MMC is closely correlated with gastric acid secretion, and the anti-gastric secretory effect of MAR-99 may mainly contribute to prevent the degranulation of MMC.
Regulation of C3 and factor H synthesis of human glomerular mesangial cells by IL-1 and interferon-gamma (1994)

Previous reports have shown production of complement components C4, C2 and factor B by renal tissue. We have shown recently that human proximal tubular epithelial cells (PTEC) synthesize C3 in vitro, and that IL-2 enhances this production. In the present study we demonstrate that human mesangial cells (MC) in culture produce factor H and that supernatants of activated peripheral blood mononuclear cells (T cell growth factor (TCGF)) induce C3 production and enhance factor H synthesis in both a time- and dose-dependent manner. To investigate whether certain defined cytokines from TCGF were responsible for the observed effect, we tested various cytokines for their effect on complement production by MC. It is shown that IL-1 induces C3 synthesis whereas factor H production is up-regulated by IFN-gamma, in both a dose- and time-dependent manner. Antibody blocking experiments revealed that C3 synthesis induced by both TCGF and IL-1 could be blocked with antibodies specific for IL-1, and also that TCGF and IFN-gamma enhanced factor H synthesis could both be blocked with antibodies specific for IFN-gamma. Cycloheximide was able to inhibit C3 and factor H production, suggesting de novo synthesis of the proteins. mRNA-polymerase chain reaction (PCR) analysis revealed mRNA encoding for C3 after stimulation with TCGF and IL-1. Factor H genes are constitutively expressed in cultured mesangial cells and its expression is up-regulated by TCGF and IFN-gamma. Northern blot analysis with specific probes for C3 and factor H revealed bands which support the results obtained by PCR analysis.
ChemInform Abstract: A Practical Ex‐Chiral‐Pool Synthesis of β‐Proline (XI) and Homo‐β‐Proline (XVI). (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Modeling the Performance of the Hadoop Online Prototype (2011)

MapReduce is an important paradigm to support modern data-intensive applications. In this paper we address the challenge of modeling performance of one implementation of MapReduce called Hadoop Online Prototype (HOP), with a specific target on the intra-job pipeline parallelism. We use a hierarchical model that combines a precedence model and a queuing network model to capture the intra-job synchronization constraints. We first show how to build a precedence graph that represents the dependencies among multiple tasks of the same job. We then apply it jointly with an approximate Mean Value Analysis (aMVA) solution to predict mean job response time and resource utilization. We validate our solution against a queuing network simulator in various scenarios, finding that our performance model presents a close agreement, with maximum relative difference under 15%.
HSP60 Speaks to the Immune System in Many Voices (2008)

Heat shock proteins (HSP) were initially identified as a family of stress-induced proteins characterized by their chaperone activity. HSP, however, are also important players in the control of the immune response: HSP are targeted by HSP-specific T cells and antibodies in healthy subjects and also during the course of autoimmune disorders and, conversely, HSP influence the activity of several immune cell types via innate receptor signalling pathways. In addition, the immune response to HSP can be mined for information on the state of the immune system. Newborns carry autoantibodies to HSP. However, this natural autoreactivity to HSP is modified by inflammation, and these changes can be monitored as biomarkers during postnatal life. Using antigen microarrays, we have shown that autoantibody patterns identify individuals prone to develop autoimmune diabetes before disease onset. Moreover, changes in the inflammatory process in multiple sclerosis are also reflected in the antibody response to self-HSP. Herein, we discuss the relevance of HSP and their immune activities for the regulation and monitoring of inflammation and autoimmune disease.
Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles (2013)

Excessive inflammation and failed resolution of the inflammatory response are underlying components of numerous conditions such as arthritis, cardiovascular disease, and cancer. Hence, therapeutics that dampen inflammation and enhance resolution are of considerable interest. In this study, we demonstrate the proresolving activity of sub-100-nm nanoparticles (NPs) containing the anti-inflammatory peptide Ac2-26, an annexin A1/lipocortin 1-mimetic peptide. These NPs were engineered using biodegradable diblock poly(lactic-co-glycolic acid)-b-polyethyleneglycol and poly(lactic-co-glycolic acid)-b-polyethyleneglycol collagen IV-targeted polymers. Using a self-limited zymosan-induced peritonitis model, we show that the Ac2-26 NPs (100 ng per mouse) were significantly more potent than Ac2-26 native peptide at limiting recruitment of polymononuclear neutrophils (56% vs. 30%) and at decreasing the resolution interval up to 4 h. Moreover, systemic administration of collagen IV targeted Ac2-26 NPs (in as low as 1 µg peptide per mouse) was shown to significantly block tissue damage in hind-limb ischemia-reperfusion injury by up to 30% in comparison with controls. Together, these findings demonstrate that Ac2-26 NPs are proresolving in vivo and raise the prospect of their use in chronic inflammatory diseases such as atherosclerosis.
Picosecond intersubband hole relaxation in p-type quantum wells (2018)

We report the first direct measurement of the relaxation time of holes in p-type quantum wells using tunable, subpicosecond mid-infrared laser pulses in a pump-probe arrangement. The QW layers consisted of 50 In{sub 0.5}Ga{sub 0.5}As/Al{sub 0.5}Ga{sub 0.5}As periods. The In{sub 0.5}Ga{sub 0.5}As well was 4 nm wide and the Al{sub 0.5}Ga{sub 0.5}As barrier was 8 nm wide. The dopant concentration was 10{sup 19} CM{sup -3} which corresponds to a sheet density of 1.2 x 10{sup 13} CM{sup -2}. The room temperature IR spectrum showed a 50 meV wide absorption peak at 5.25 {mu}m (220 meV). This energy agrees with the calculated n=1 heavy hole to n=1 light hole transition energy of 240 meV (150 meV for strain and 90 meV for confinement). The large absorption width results from hole-hole scattering and the difference in dispersion relations between the two subbands. The equal-wavelength pump-probe transmission measurements were performed using the Stanford free electron laser (FEL). The FEL pulses were tuned between 4 and 6 {mu} m and their duration was less than 1 ps. The measurements were performed as a function of temperature, pump wavelength and intensity (from 0.3 to 10 GW/cm{sup 2}). In all our experiments, we find an increase of transmission (decrease of absorption or bleaching) following photopumping, which recovers as a single exponential with a time constant (relaxation time) of the order of 1 picosecond. The maximum change in transmission is linear with pump 2 intensity below 1 GW/cm{sup 2} and saturates to {approximately}3% with a saturation intensity I{sub sat} of 3 GW/cm{sup 2}. As the saturation regime is entered, the relaxation time increases from 0.8 ps to 1.8 ps. This relaxation time depends on the temperature T: it increases from 0.8 ps to 1.3 ps as T decreases from 300 K to 77 K. Finally, when we tune the laser through the absorption band, the magnitude of the signal changes but its temporal behavior does not change, within the accuracy of the measurements.
It's the Wrong Virus: Rapid Adaptation of Operations Inside a Highly Pathogenic Avian Influenza Select Agent Laboratory in Response to the 2019 SARS-CoV-2 Pandemic (2022)

The demands placed on biocontainment laboratories for response to SARS-CoV-2 has highlighted the importance of a robust BMS. In a relatively short time, the ABSL-3+ was able to adapt from a single select agent space to a multipathogen laboratory and expand our pandemic response capacity.
Noisy Constrained Maximum-Likelihood Linear Regression for Noise-Robust Speech Recognition (2010)

Adaptive training is a widely used technique for building speech recognition systems on nonhomogeneous training data. Recently, there has been interest in applying these approaches for situations where there is significant levels of background noise in the training data. Various schemes for adaptive training are based on noise-, or speaker-, specific transforms of features to yield estimates of the clean speech. However, when there are high levels of background noise, these clean speech estimates may be poor resulting in degradations in performance. In this paper, a new approach for adaptive training on noise-corrupted training data is presented. It extends a popular form of linear transform for model-based adaptation and adaptive training, constrained MLLR (CMLLR), to reflect additional uncertainty from noise-corrupted observations. This new form of adaptation transform is called noisy CMLLR (NCMLLR). NCMLLR uses a modified version of generative model between clean speech and noisy observation, similar to factor analysis (FA). However, in contrast to FA here the generative model describes an adaptation transform, rather than a covariance matrix structure. The use of NCMLLR for adaptive training using an expectation-maximization approach is described. Discriminative adaptive training with NCMLLR is also described based on the minimum phone error criterion. Experimental results comparing NCMLLR with standard adaptive training schemes are given on a noise-corrupted version of Resource Management, the ARPA 1994 CSRNAB Spoke 10 task, and in-car recorded data.
Nanochannel-based electrochemical sensor for the detection of pharmaceutical contaminants in water (2013)

Effective real-time monitoring is the key to understanding and tackling the issue of pharmaceutical contamination of water. This research demonstrates the utility of an alumina nanochannel-based electrochemical sensor platform for the detection of ibuprofen in water derived from various sources. Our results indicate that the sensor is highly sensitive with a limit of detection at 0.25 pg mL(-1). The novel sensor described here has potential for application as a simple, rapid, inexpensive and highly reliable method for real-time environmental water quality assessment.
Inhibition of LPS‐induced chemokine production in human lung endothelial cells by lipid conjugates anchored to the membrane (2002)

1. In acute respiratory distress syndrome (ARDS) induced by endotoxins, a high production of inflammatory mediators by microvascular lung endothelial cells (LMVEC) can be observed. Activation of cells by endotoxins may result in elevated secretion of phospholipase A(2) (sPLA(2)) which is thought to contribute to tissue damage. The present study was undertaken to investigate the role of sPLA(2) in chemokine production in human lung microvascular endothelial cells (LMVEC) stimulated with the endotoxins lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In particular, we investigated the effects of sPLA(2) inhibitors, specifically, the extracellular PLA(2) inhibitors (ExPLIs), composed of N-derivatized phosphatidyl-ethanolamine linked to polymeric carriers, and LY311727, a specific inhibitor of non-pancreatic sPLA(2). 2. ExPLIs markedly inhibited LPS and LTA induced production and mRNA expression of the neutrophile attracting chemokines IL-8, Gro-alpha and ENA-78, as well as of the adhesion molecules ICAM-1 and E-selectin. Concomitantly, ExPLIs inhibited the LPS-induced activation of NF-kappaB by LPS but not its activation by TNF-alpha or IL-1. 3. Endotoxin mediated chemokine production in LMVEC seems not to involve PLA(2) activity, since LPS stimulation was not associated with activation of intracellular or secreted PLA(2). It therefore seems that the inhibitory effect of the ExPLIs was not due to their PLA(2) inhibiting capacity. This was supported by the finding that the LPS-induced chemokine production was not affected by the selective sPLA(2) inhibitor LY311727. 4. It is proposed that the ExPLIs may be considered a prototype of potent suppressors of specific endotoxin-induced inflammatory responses, with potential implications for the therapy of subsequent severe inflammation.
Influence of molecular structure on the free radical initiated network polymerization of dimethacrylates (1996)

Abstract The free radical polymerization of several new dimethacrylates initiated by azobisisobutyronitrile (AIBN) at various temperatures was investigated by differential scanning calorimetry (DSC), Fourier transform infrared (FT‐IR), and solid state NMR. The new monomers contained features, such as fluoroalkyl and/or pendant methyl or hydrogen instead of hydroxyl groups, which promoted both low viscosity and low monomer glass transition temperatures. The percent conversion was significantly improved, relative to a well‐studied control dimethacrylate as measured by both DSC and FT‐IR. Increasing the reaction temperature and the initiator concentration also led to enhanced conversion behavior and the apparent activation energies for the polymerization are reported. The results suggests that the new crosslinked material systems could show several advantages relative to the control bisphenol‐A based diglycidyl methacrylate.
Supplementary Figure S1 from Tumor Cell–Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression (2023)

&lt;p&gt;Supplementary Figure S1. Effects on haptotaxis are independent of effects on cell velocity.&lt;/p&gt;
Materials comprising polydienes and hydrophilic polymers and related methods (2023)

Materials prepared from polydienes, such as poly(cyclohexadiene), and hydrophilic polymers, such as poly(alkylene oxide), are described. Methods of making the materials and their use in fuel cell membranes, batteries, breathable chemical-biological protective materials, and templates for sol-gel polymerization are also provided. The materials can be crosslinked and sulfonated, and can include copolymers and polymer blends.
Further improvements in CGR formulation and process (1994)

In previous papers, we described initial evaluations of CGR 248 negative resist using a variety of exposure tools. During subsequent studies, the emphasis has been placed on optimizing material and process for Micrascan and Micrascan II pilot line and manufacturing operations. The formulation is based on polyhydroxystyrene (PHS), tetramethoxymethyl glycoluril, and a sulfonate ester of an N-hydroxy compound. We will discuss image stability as a function of delay time between post apply bake (PA) and expose and as a function of delay time between expose and the post expose bake (PEB). Further, data will show that immersion or puddle development provides a larger process window than spray development for features in the 0.30 to 0.35 micrometers range. The thermal stability of the imaged resist will be discussed as well as the shelf life which is at least 6 months at 23 degree(s) C. Finally, additional data is available concerning image uniformity and how print bias and etch bias contribute to the overall nested-isolated line offset for positive tone (APEX-M) and negative tone (CGR) resists. Data obtained from Micrascan II exposures with test reticles will demonstrate an acceptable process latitude for 0.30 and 0.35 micrometers features and a wafer to wafer image uniformity similar to that observed for APEX.
MiR-199a-3p Regulates mTOR and c-Met to Influence the Doxorubicin Sensitivity of Human Hepatocarcinoma Cells (2010)

MicroRNAs (miRNA) have rapidly emerged as modulators of gene expression in cancer in which they may have great diagnostic and therapeutic import. MicroRNA-199a-3p (miR-199a-3p) is downregulated in several human malignancies including hepatocellular carcinoma (HCC). Here, we show that miR-199a-3p targets mammalian target of rapamycin (mTOR) and c-Met in HCC cells. Restoring attenuated levels of miR-199a-3p in HCC cells led to G(1)-phase cell cycle arrest, reduced invasive capability, enhanced susceptibility to hypoxia, and increased sensitivity to doxorubicin-induced apoptosis. These in vitro findings were confirmed by an analysis of human HCC tissues, which revealed an inverse correlation linking miR-199a-3p and mTOR as well as a shorter time to recurrence after HCC resection in patients with lower miR-199a-3p expression. These results suggest that tactics to regulate mTOR and c-Met by elevating levels of miR-199a-3p may have therapeutic benefits in highly lethal cancers such as HCC.
Passive derivation of basic walker-assisted gait characteristics from measured forces and moments (2005)

This work describes a method that passively assesses basic walker-assisted gait characteristic, including heel strikes, toe-off events, as well as stride time, double support and right & left single support phases using only force-moment measurements from the walker's handles. The passively derived gait characteristics were validated against motion capture gait analysis and showed good correlations. This research is part of an effort that aims to identify user intent, from measuring forces and moments exerted on the handles of the walker as well as from perceiving the environment, and to incorporate identified intent into a passive shared steering control system for the walker. The primary focus of the work leading to This work is to identify the double support phase, and to engage the steering control at the beginning of this phase to maximize the user's stability. However, the application of the method presented and the instrumented walker can be extended to longitudinal outside the lab Gait assessment.
Supplementary Data TS1 from Microparticle Encapsulation of a Prostate-targeted Biologic for the Treatment of Liver Metastases in a Preclinical Model of Castration-resistant Prostate Cancer (2023)

&lt;p&gt;Tbl S1&lt;/p&gt;
Performance of coherent adaptive antenna array beamforming combined with MRC diversity techniques in W-CDMA reverse link (2002)

This paper presents coherent adaptive antenna array beamforming (CAAA-BF) combined with maximal ratio combining (MRC) diversity techniques (space diversity, SD, or polarization diversity, PD) and evaluates the interference suppression effect of these methods under multipath fading in the W-CDMA reverse link. Computer simulation results show that even when the number of active users is 150 (note that the capacity normalized by the processing gain, Pg, is 78%), the required transmit signal energy-per-bit-to-background-noise power spectrum density ratio (E/sub b//N/sub 0/) at the average block error rate (BLER) of 10/sup -2/ with CAAA-BF with 2-branch SD reception, i.e., 4 antennas per branch, is decreased by approximately 1.4 dB compared to that with CAAA-BF using 8 antennas. These results indicate that by combining CAAA-BF with diversity techniques, although the interference suppression effect is slightly decreased compared to that with CAAA-BF using the identical number of antennas in an interference-limited channel, due to the broadening beam width, there is a significant additional space diversity effect especially when the number of resolved paths is small.
Impact of operation parameters on the degradation of 233 nm AlGaN-based far-UVC LEDs (2022)

The impact of the operation parameters current and temperature on the degradation of AlGaN-based 233 nm far-ultraviolet-C LEDs is investigated. The observed effects can be divided into two groups: First, a rapid reduction in the optical power to about 50%–30% of the initial value during the first ∼100 h of operation, which is accompanied by an increase in the current below the diffusion voltage from 0.3 to about 1 μA, and a reduction in the hydrogen concentration in the p-side close to the active region. The second group is represented by a gradual reduction of the optical power, which runs in parallel to the effects in the first group and dominates for operation times ≥100 h. The reduction of the optical power is due to a decrease in the slope of the optical power–current characteristic. All effects are accelerated at increased stress currents and current densities—the reduction in the optical power at low (∼20 mA) and high measuring current (∼80 mA) scales with the current to the power of three. For example, after 250 h of operation, the relative optical power at a measuring current of 20 mA has decreased to about 40% when the LED was operated at a stress current of 20 mA and to &amp;lt;10% for a stress current of 100 mA. Furthermore, temperature has no significant impact on the reduction of the optical power during operation, i.e., the relative optical power reduced to about 25% after 250 h both when the LEDs were operated at 20 °C and when they were operated at 75 °C.