gebhart/patrepeval huggingface dataset:
The electronic patient record: a strategic planning framework. (1995)

Sunnybrook Health Science Center (Sunnybrook) is a multifacility academic teaching center. In May 1994, Sunnybrook struck an electronic patient record taskforce to develop a strategic plan for the implementation of a comprehensive, facility wide electronic patient record (EPR). The taskforce sought to create a conceptual framework which provides context and integrates decision-making related to the comprehensive electronic patient record. The EPR is very much broader in scope than the traditional paper-based record. It is not restricted to simply reporting individual patient data. By the Institute of Medicine's definition, the electronic patient record resides in a system specifically designed to support users through availability of complete and accurate data, practitioner reminders and alerts, clinical decision support systems, links to bodies of medical knowledge, and other aids [1]. It is a comprehensive resource for patient care. The taskforce proposed a three domain model for determining how the EPR affects Sunnybrook. The EPR enables Sunnybrook to have a high performance team structure (domain 1), to function as an integrated organization (domain 2), and to reach out and develop new relationships with external organizations to become an extended enterprise (domain 3) [2]. Domain 1: Sunnybrook's high performance teams or patient service units' (PSUs) are decentralized, autonomous operating units that provide care to patients grouped by 'like' diagnosis and resource needs. The EPR must provide functions and applications which promote patient focused care, such as cross functional charting and care maps, group scheduling, clinical email, and a range of enabling technologies for multiskilled workers. Domain 2: In the integrated organization domain, the EPR should facilitate closer linkages between the arrangement of PSUs into clinical teams and with other facilities within the center in order to provide a longitudinal record that covers a continuum of care. Domain 3: In the inter-enterprise domain, the EPR must allow for patient information to be exchanged with external providers including referring doctors, laboratories, and other hospitals via community health information networks (CHINs). Sunnybrook will prioritize the development of first domain functionality within the corporate constraints imposed by the integrated organization domain. Inter-enterprise computing will be less of a priority until Sunnybrook has developed a critical mass of the electronic patient record internally. The three domain description is a useful model for describing the relationship between the electronic patient record enabling technologies and the Sunnybrook organizational structures. The taskforce has used this model to determine EPR development guidelines and implementation priorities.
On the relevance of high-level features for speaker independent emotion recognition of spontaneous speech (2009)

In this paper we study the relevance of so called high-level speech features for the application of speaker independent emotion recognition. After we give a brief definition of highlevel features, we discuss for which standard feature groups high-level features are conceivable. Two groups of high-level features are proposed within this paper: a feature set for the parametrization of phonation called voice quality parameters and a second feature set deduced from music theory called harmony features. Harmony features give information about the frequency interval and chord content of the pitch data of a spoken utterance. Finally, we study the gain in classification rate by combining the proposed high-level features with the standard low-level features. We show that both high-level feature sets improve the speaker independent classification performance for spontaneous emotional speech. Index Terms: emotion recognition, high-level features, harmony features, voice quality parameters
Survivorship of Uncemented Proximally Porous-Coated Femoral Components (1995)

Three hundred seventy-five consecutive total hip arthroplasty revisions done using proximally porous-coated femoral components of 6 designs were reviewed a mean of 4.7 years after surgery. Fifty-nine hips have been rerevised for aseptic femoral loosening, and 4 for osteolysis. Moderate or severe pain was present in 23% of surviving hips, and radiographic evidence of femoral loosening was present in 38% of surviving hips at the most recent followup. At 8 years, survivorship free of revision for aseptic femoral failure (for loosening or osteolysis) was 58% (95% confidence intervals, 44.3%, 69.6%); survivorship free of aseptic femoral loosening (revision for aseptic loosening or radiographic loosening) was 20% (95% confidence intervals, 12%, 27%); and survivorship free of symptomatic femoral loosening (revision for aseptic loosening or radiographic femoral loosening with moderate or severe pain) was 45% (95% confidence intervals, 32.3%, 56%). More severe preoperative bone loss correlated with poorer survivorship free of aseptic loosening and subsidence of > or = 5 mm. Differences among the prosthetic-type groups with respect to patient's age, gender, and bone loss severity precluded direct comparison of performance for each prosthetic type; however, all the prostheses had a significant rate of rerevision and aseptic loosening. Stable long-term fixation with the proximally porous-coated femoral components used in this series was not achieved on a predictable and reproducible basis. The damaged, weakened bone often present in the proximal femur during revision probably does not provide an optimal environment for sturdy initial or long-term biologic fixation of these devices that rely on the proximal femoral bone for fixation.
Analysis of the effects of the variation in the demand of products in a Steel Industry: a System Dynamics approach (2005)

International audience
EACAN (2019)

Worst-case-based timing verification for the controller area network (CAN) has been the bottleneck to efficient use of its bandwidth. Especially, this inefficiency comes from the worst-case transmission error rate (WCTER) when transmission errors are accounted for. To alleviate this inefficiency, we propose a runtime adaptation scheme, error-adaptive CAN (EACAN). EACAN observes the behavior of transmission errors at runtime, and reconfigures the message period based on the observation to meet the timing-failure requirement. We experimentally evaluate the bandwidth utilization of both EACAN- and WCTER-based verification, showing that the former improves the bandwidth utilization by 14% over the latter.
Flexible processor based on full-adder/ d-flip-flop merged module (2001)

Flexible processor based on full-adder/D-flip-flop merged module (FDMM) has been designed and fabricated. The developed FDMM has unique ability to perform both logic and flip-flop functions with a small transistor count by merging the common part of both circuits. We have also developed a context memory block to reconfigure the hardware dynamically. The flexible processor may fill a gap between hardware performance and programmability to jump into novel computing such as software/hardware synthesis; software accelerator.
Wafer-scale nanofabrication of functional metasurfaces (2022)

In this talk, we report a large-scale fabrication of Mid-IR metasurfaces by using a newly developed method. The metasurfaces were produced on transparent alumina membranes. Functionalities such as quasi-bound-state-in-the-continuum (quasi-BIC) resonances, mid-IR focusing, and polarization control were realized in different dielectric metasurfaces. Metasurfaces comprising aluminum nanoantennas were also fabricated and integrated into microfluidic devices for biosensing. The reported fabrication method is CMOS compatible and able to produce metasurfaces over whole Si wafers with high precision and uniformity. This work serves as a significant step in the direction of practical applications and commercialization of Mid-IR metasurfaces [Adv. Mater. 33, 2102232 (2021)].
Comparison of Feeding Behavior of the Potato LeafhopperEmpoasca fabae(Homoptera: Cicadellidae) on Alfalfa and Broad Bean Leaves (1989)

A quantitative comparison was made of the feeding behavior of the potato leafhopper, Empoasca fabae (Harris), on the leaves of two host plants, alfalfa ( Medicago sativa L.) and broad bean ( Vicia Jaba L.), using an AC electronic feeding monitor. Results showed significant differences in feeding between the two hosts, primarily because of the variable occurrence of still-stylet ingestion, a behavior (correlated with the I c , waveform) that may indicate ingestion of phloem sap. The similarities between the hosts were due to the dominance of the lacerate-and-flushfeeding style in mesophyll and perhaps some phloem tissues, represented by the I a , waveform. Differences in feeding between hosts probably contribute to the wide host range of this species, as well as the differences in feeding injury on these two crop plants.
Vinyl Benzenes as Dienes in Mild Solid-Phase Diels−Alder Reactions (2000)

Wang resin-bound intermediates derived from Fmoc-L-phenylalaninal and Fmoc-L-valinal, and a resin supported Horner-Wadsworth-Emmons reaction, were treated with cinnamaldehyde derivatives, acetic acid, and borohydride to give secondary amines which were subsequently benzoylated to afford various derivatives of 3. Heating 3 at 95 degrees C induced cycloaddition reactions and produced 4 as the major product. Compounds 3 which were derived from 4-methoxycinnamaldehyde were more reactive, but did not give 4 and 4-7g. The direct cleavage of 3b using TFA led to the isolation of cycloaddition-demethylation product 10. The derivative of 3, which contained an electron-withdrawing nitro group on the phenyl ring, produced a single diastereomer of 4. The Diels-Alder cycloaddition between two electron-deficient counterparts showed similar reactivity to that of the reactions which have a normal complementary electron-demand.
Classification and Identification of Mycobacterium africanum by Pyrolysis Mass Spectrometry (1983)

Pyrolysis mass spectrometry was used to classify and identify strains of Mycobacterium africanum and of M. tuberculosis, M. bovis and M. bovis BCG. The multicharacter mass pyrograms were evaluated by computerized data handling procedures that were suited for classification and identification. The results revealed considerable heterogeneity among the African strains, which was shown to be linked to the geographic distribution of the strains. On the basis of a routine mass spectrometric identification key the African strains were identified without exception as belonging to, what is referred to as the 'Tuberculosis complex' (i.e. the clinically relevant group formed by strains of M. Tuberculosis, M. bovis and M. bovis BCG). Classification of the strains by means of discriminant analysis indicated an intermediate clustering for the majority of the African strains and overlap for some African strains with in particular M. bovis. It was concluded that from the mass spectrometric data a species status for the group of African strains was not justifiable.
Identification and characterization of yeast mutants that overcome an experimentally introduced block to splicing at the 3' splice site. (1996)

An experimentally introduced secondary structure in exon 2 adjacent to the 3' splice site of a yeast ACT-Escherichia coli lacZ fusion gene abolishes splicing in vivo and inhibits beta-galactosidase production. We have devised a genetic screen to isolate both cis and trans-acting mutants that restore beta-galactosidase activity. Two cis-acting mutants potentially destabilize the stem in the region close to the 3' splice site. One trans-acting mutant, designated rss1-1, partially restores beta-galactosidase activity by both increasing the splicing efficiency and stabilizing the precursor and lariat intermediate. The trans-acting suppression activity of rss1-1 is specific for a particular structure because another artificially introduced secondary structure, which also blocks splicing, is not suppressed by this mutant allele. We have cloned the gene encoding the trans-acting mutant protein. The RSS1 gene is located on Saccharomyces cerevisiae chromosome V and is a single copy, essential gene. The predicted RSS1 protein has marked similarity to members of the putative ATP-dependent RNA helicase family. At the nonpermissive temperature, the rss1-1 mutant allele decreases the steady-state levels of several endogenous messenger RNAs and increases the ratio of pre-mRNA to mRNA of specific messages. RSS1 is likely to play an interesting role in RNA processing.
Voltage Control Comparison for Low-Power DC-DC Converters in EVs: PI and Explicit MPC (2018)

Multilevel converters are used to improve the traction converter of modern electric vehicles (EV). Such topologies can be applied even to low-power converter such as dc-dc auxiliary converters, to improve the EV overall efficiency. The low voltage rating of auxiliary circuits implies the usage of low-cost hardware both for power as well for control platforms. A cost-effective explicit model predictive control (eMPC) is designed for a three-level neutral point clamped step-down dc-dc auxiliary converter and compared to an eMPC for a two-level solution. Both eMPCs are compared to a classical PI-type voltage control.
An update on fractional picosecond laser treatment: histology and clinical applications (2023)

Picosecond lasers have a very short pulse duration and a high peak power density. When fractional optical delivery systems are attached to picosecond lasers, they generate an array of concentrated microspots with a high fluence surrounded by areas with a low fluence. This article discusses the histologic characteristics and clinical applications of fractional picosecond laser treatment. Fractional picosecond laser produces laser-induced optical breakdown (LIOB) and laser-induced cavitation (LIC) in the epidermis and dermis respectively, and can encourage skin regeneration and dermal remodeling. It has been shown that fractional picosecond laser has a positive effect on facial photoaging, enlarged facial pores, dyspigmentation, wrinkles, and atrophic scars. Further research is still needed to confirm the benefits of fractional picosecond lasers.
The analog formulation of sparsity implies infinite divisibility and rules out Bernoulli-Gaussian priors (2012)

Motivated by the analog nature of real-world signals, we investigate continuous-time random processes. For this purpose, we consider the stochastic processes that can be whitened by linear transformations and we show that the distribution of their samples is necessarily infinitely divisible. As a consequence, such a modeling rules out the Bernoulli-Gaussian distribution since we are able to show in this paper that it is not infinitely divisible. In other words, while the Bernoulli-Gaussian distribution is among the most studied priors for modeling sparse signals, it cannot be associated with any continuous-time stochastic process. Instead, we propose to adapt the priors that correspond to the increments of compound Poisson processes, which are both sparse and infinitely divisible.
Gastrointestinal Stromal Tumors (2017)

GI stromal tumors (GISTs) are neoplasms with a varying malignancy potential ranging from virtually indolent tumors to rapidly progressing cancers. GISTs occur throughout the intestinal tract, and most harbor an activating mutation in either KIT or platelet-derived growth factor A ( PDGFRA). Diagnosis is made using immunohistochemistry, but molecular testing with mutation analysis is paramount for selection of appropriate therapy. Most small GISTs are cured with surgery. Tyrosine kinase inhibitor (TKI) therapy has led to substantial improvements in survival, both for patients with localized GIST and those with advanced disease. Adjuvant therapy with imatinib benefits patients with a high risk of recurrence, with studies suggesting most benefit with at least 3 years of therapy. Neoadjuvant imatinib therapy should be considered for patients requiring extensive surgery, aiming at shrinking the tumor to allow organ preservation and less extensive surgery. The following three TKIs have been approved for the management of advanced disease: imatinib, sunitinib, and regorafenib; imatinib is usually the best tolerated of the three and the standard first-line treatment. TKIs benefit the majority of patients with advanced GIST but have no or limited efficacy in patients with the PDGFRA D842V mutation or patients with GIST lacking KIT and PDGFRA mutations. Surgery, the mainstay of primary tumor management, also plays a role in the advanced disease setting for selected patients, as do some other approaches such as palliative radiation therapy. Research continues to identify novel therapies, in particular effective agents to treat TKI-refractory disease.
ICONE15-10812 LASER PEENING WITHOUT PROTECTIVE COATING AS A SURFACE ENHANCEMENT TECHNOLOGY (2007)

The effects of laser peening without protective coating (LPwC) have been experimentally studied on residual stress, stress corrosion cracking (SCC) susceptibility and fatigue properties. Compressive residual stress nearly equal to the yield strength appeared on the surface of SUS304, Alloy 600, Alloy 182 and Alloy 132. The affected depth reached 1 mm or more from the surface of the materials after LPwC. The residual stress on the top surface was precisely studied with high-energy, high-brilliance and highly parallelized X-ray of SPring-8. The top surface was entirely compressive in spite of the possible heat effect by the direct irradiation of laser pulses to the materials. Redistribution of residual stress in a thin wall component due to LPwC was confirmed by neutron diffraction experiment at Japan Research Reactor-3 (JRR-3). Accelerating stress corrosion cracking (SCC) tests in a high temperature and pressure environment showed that LPwC significantly reduced the SCC susceptibility of sensitized materials. High-cycle fatigue tests demonstrated that LPwC drastically prolonged the fatigue life of SUS316L, despite the increase in the surface roughness. A newly developed ultra-compact laser system is also described, which combines both characteristics of mirror- and fiberdelivery systems and could considerably extend the applicability of LPwC.
Automated cell-type classification in intact tissues by single-cell molecular profiling (2018)

A major challenge in biology is identifying distinct cell classes and mapping their interactions in vivo. Tissue-dissociative technologies enable deep single cell molecular profiling but do not provide spatial information. We developed a proximity ligation in situ hybridization technology (PLISH) with exceptional signal strength, specificity, and sensitivity in tissue. Multiplexed data sets can be acquired using barcoded probes and rapid label-image-erase cycles, with automated calculation of single cell profiles, enabling clustering and anatomical re-mapping of cells. We apply PLISH to expression profile ~2900 cells in intact mouse lung, which identifies and localizes known cell types, including rare ones. Unsupervised classification of the cells indicates differential expression of 'housekeeping' genes between cell types, and re-mapping of two sub-classes of Club cells highlights their segregated spatial domains in terminal airways. By enabling single cell profiling of various RNA species in situ, PLISH can impact many areas of basic and medical research.
Data from Eradication of Solid Human Breast Tumors in Nude Mice with an Intravenously Injected Light-Emitting Oncolytic Vaccinia Virus (2023)

&lt;div&gt;Abstract&lt;p&gt;Previously, we reported that a recombinant vaccinia virus (VACV) carrying a light-emitting fusion gene enters, replicates in, and reveals the locations of tumors in mice. A new recombinant VACV, GLV-1h68, as a simultaneous diagnostic and therapeutic agent, was constructed by inserting three expression cassettes (encoding &lt;i&gt;Renilla&lt;/i&gt; luciferase–&lt;i&gt;Aequorea&lt;/i&gt; green fluorescent protein fusion, β-galactosidase, and β-glucuronidase) into the &lt;i&gt;F14.5L, J2R&lt;/i&gt; (encoding thymidine kinase) and &lt;i&gt;A56R&lt;/i&gt; (encoding hemagglutinin) loci of the viral genome, respectively. I.v. injections of GLV-1h68 (1 × 10&lt;sup&gt;7&lt;/sup&gt; plaque-forming unit per mouse) into nude mice with established (∼300–500 mm&lt;sup&gt;3&lt;/sup&gt;) s.c. GI-101A human breast tumors were used to evaluate its toxicity, tumor targeting specificity, and oncolytic efficacy. GLV-1h68 showed an enhanced tumor targeting specificity and much reduced toxicity compared with its parental LIVP strains. The tumors colonized by GLV-1h68 exhibited growth, inhibition, and regression phases followed by tumor eradication within 130 days in 95% of the mice tested. Tumor regression in live animals was monitored in real time based on decreasing light emission, hence demonstrating the concept of a combined oncolytic virus–mediated tumor diagnosis and therapy system. Transcriptional profiling of regressing tumors based on a mouse-specific platform revealed gene expression signatures consistent with immune defense activation, inclusive of IFN-stimulated genes (&lt;i&gt;STAT-1&lt;/i&gt; and &lt;i&gt;IRF-7&lt;/i&gt;), cytokines, chemokines, and innate immune effector function. These findings suggest that immune activation may combine with viral oncolysis to induce tumor eradication in this model, providing a novel perspective for the design of oncolytic viral therapies for human cancers. [Cancer Res 2007;67(20):10038–46]&lt;/p&gt;&lt;/div&gt;
The prostamide‐related glaucoma therapy, bimatoprost, offers a novel approach for treating scalp alopecias (2012)

Balding causes widespread psychological distress but is poorly controlled. The commonest treatment, minoxidil, was originally an antihypertensive drug that promoted unwanted hair. We hypothesized that another serendipitous discovery, increased eyelash growth side-effects of prostamide F(2α)-related eyedrops for glaucoma, may be relevant for scalp alopecias. Eyelash hairs and follicles are highly specialized and remain unaffected by androgens that inhibit scalp follicles and stimulate many others. Therefore, we investigated whether non-eyelash follicles could respond to bimatoprost, a prostamide F(2α) analog recently licensed for eyelash hypotrichosis. Bimatoprost, at pharmacologically selective concentrations, increased hair synthesis in scalp follicle organ culture and advanced mouse pelage hair regrowth in vivo compared to vehicle alone. A prostamide receptor antagonist blocked isolated follicle growth, confirming a direct, receptor-mediated mechanism within follicles; RT-PCR analysis identified 3 relevant receptor genes in scalp follicles in vivo. Receptors were located in the key follicle regulator, the dermal papilla, by analyzing individual follicular structures and immunohistochemistry. Thus, bimatoprost stimulates human scalp follicles in culture and rodent pelage follicles in vivo, mirroring eyelash behavior, and scalp follicles contain bimatoprost-sensitive prostamide receptors in vivo. This highlights a new follicular signaling system and confirms that bimatoprost offers a novel, low-risk therapeutic approach for scalp alopecias.
Novel compounds for the treatment of Chagas disease. (2009)

M. Keenan1, M. Abbott1, T. Akama5, P. Alexander1, T. Armstrong2, W. M. Best1, B. Berven1, A. Botero2, J. Chaplin1, S. Charman3, E. Chatelain4, H. Diao1, E. Easom5, T. Von Geldern4, M. Kerfoot2, A. Khong2, J. McManus1, I. Scandale4, A. R. Thompson3, Z. Wang1, K. White3 1Epichem, Murdoch, WA, Australia 2Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA, Australia 3Centre for Drug Candidate Optimisation, Monash University, Parkville, VIC, Australia 4Drugs for Neglected Diseases initiative, Geneva, Switzerland 5Anacor Pharmaceuticals, Inc, Palo Alto, CA, United States