gebhart/patrepeval huggingface dataset:
Miscibility in poly(vinylethylene) isotopic mixtures by carbon-13 NMR (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMiscibility in poly(vinylethylene) isotopic mixtures by carbon-13 NMRK. J. McGrath and C. M. RolandCite this: Macromolecules 1992, 25, 1, 166–169Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/ma00027a028https://doi.org/10.1021/ma00027a028research-articleACS PublicationsRequest reuse permissionsArticle Views22Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Clinical Outcomes of Microscopic versus Endoscopic Surgical Approaches following Transsphenoidal Pituitary Tumor Resection (2023)

Introduction: Transsphenoidal surgical resection (TSR) is the most common surgical procedure used in the resection of pituitary tumors. There has been an ongoing debate on the effectiveness of two different transsphenoidal methods: endoscopic and microscopic sublabial approaches. Endoscopic TSR has been studied over the past decade and evidence has shown that in 2010, 43% pituitary surgeons preferred the endoscope over the microscope whereas in 2020, 87% pituitary surgeons preferred the endoscope over the microscope. While this finding is suggestive of a growing preference for endoscopic TSR, differences in clinical outcomes between the two approaches have not yet been studied ([Fig. 1]).
Supplementary Figure 3 from Targeting CD4<sup>+</sup> T-Helper Cells Improves the Induction of Antitumor Responses in Dendritic Cell–Based Vaccination (2023)

&lt;p&gt;PDF file - 34K, KLH specific responses&lt;/p&gt;
Efficient breadth-first manipulation of binary decision diagrams (1994)

We propose new techniques for efficient breadth-first iterative manipulation of ROBDDs. Breadth-first iterative ROBDD manipulation can potentially reduce the total elapsed time by multiple orders of magnitude compared to the conventional depth-first recursive algorithms when the memory requirement exceeds the available physical memory. However, the breadth-first manipulation algorithms proposed so far have had a large enough overhead associated with them to make them impractical. Our techniques are geared towards minimizing the overhead without sacrificing the speed up potential. Experimental results indicate considerable success in that regard.
Long-term transport and stability properties of thermoset resins exposed to water (2007)

The intermittent administration of methamphetamine produces behavioral sensitization to methamphetamine. In the limbic forebrain, mainly including the nucleus accumbens, of mice that had been intermittently treated with methamphetamine, we found a significant increase in mRNA of a chemokine, CCR2. This increase was accompanied by a significant increase in histone H3 lysine 4 (H3K4) trimethylation at its promoter. Interestingly, the maintenance of sensitization to methamphetamine-induced hyperlocomotion was significantly decreased in CCR2 knockout mice. These findings suggest that increased CCR2 associated with epigenetic modification after the intermittent administration of methamphetamine may be associated with the maintenance of sensitization to methamphetamine-induced hyperlocomotion.
Blood transfusions recruit the microcirculation during cardiac surgery (2010)

In this study we have shown that blood transfusion: 1) improves the systemic circulation and oxygen-carrying capacity, 2) improves sublingual microcirculatory density but not perfusion velocity, and 3) improves microcirculatory oxygen saturation.
Effects of glucagon-like peptide-1-(7–36)-amide on pancreatic islet and intestinal blood perfusion in Wistar rats and diabetic GK rats (2007)

The aim of the present study was to evaluate the effects of GLP-1 [glucagon-like peptide-1-(7-36)-amide] on total pancreatic, islet and intestinal blood perfusion in spontaneously hyperglycaemic GK rats and normal Wistar rats using a microsphere technique. GK rats had hyperglycaemia and increased pancreatic and islet blood flow. Blood glucose concentrations were not affected when measured shortly (8 min) after GLP-1 administration in either GK or Wistar rats. GLP-1 had no effects on baseline pancreatic or islet blood flow in Wistar rats, but did prevent the blood flow increase normally seen following glucose administration to these animals. In GK rats, administration of GLP-1 decreased both pancreatic and islet blood flow. Glucose administration to the GK rats decreased pancreatic and islet blood flow. This decrease was not affected by pre-treatment with GLP-1. We conclude that administration of GLP-1 leads to a decrease in the augmented blood flow seen in islets of diabetic GK rats. The GLP-1-induced action on islet blood perfusion may modulate output of islet hormones and contribute to the antidiabetogenic effects of the drug in Type 2 diabetes (non-insulin-dependent diabetes).
Monthly Unannounced Pill Counts for Monitoring HIV Treatment Adherence: Tests for Self-Monitoring and Reactivity Effects (2010)

Unannounced pill counts conducted by telephone do not demonstrate reactivity effects and remain a viable, unobtrusive, objective method of monitoring medication adherence.
Synthesis of Pyrrolidine Monocyclic Analogues of Pochonicine and Its Stereoisomers: Pursuit of Simplified Structures and Potent β-N-Acetylhexosaminidase Inhibition (2020)

Ten pairs of pyrrolidine analogues of pochonicine and its stereoisomers have been synthesized from four enantiomeric pairs of polyhydroxylated cyclic nitrones. Among the ten N-acetylamino pyrrolidine analogues, only compounds with 2,5-dideoxy-2,5-imino-d-mannitol (DMDP) and pochonicine (1) configurations showed potent inhibition of β-N-acetylhexosaminidases (β-HexNAcases); while 1-amino analogues lost almost all their inhibitions towards the tested enzymes. The assay results reveal the importance of the <i>N</i>-acetylamino group and the possible right configurations of pyrrolidine ring required for this type of inhibitors.
Supplementary Table 2 from A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors (2023)

&lt;p&gt;Histological diagnosis, age, number of cycles received and Overall Survival&lt;/p&gt;
Oxygen Limitation within a Bacterial Aggregate (2014)

ABSTRACT Cells within biofilms exhibit physiological heterogeneity, in part because of chemical gradients existing within these spatially structured communities. Previous work has examined how chemical gradients develop in large biofilms containing >10(8) cells. However, many bacterial communities in nature are composed of small, densely packed aggregates of cells (≤ 10(5) bacteria). Using a gelatin-based three-dimensional (3D) printing strategy, we confined the bacterium Pseudomonas aeruginosa within picoliter-sized 3D "microtraps" that are permeable to nutrients, waste products, and other bioactive small molecules. We show that as a single bacterium grows into a maximally dense (10(12) cells ml(-1)) clonal population, a localized depletion of oxygen develops when it reaches a critical aggregate size of ~55 pl. Collectively, these data demonstrate that chemical and phenotypic heterogeneity exists on the micrometer scale within small aggregate populations. IMPORTANCE Before developing into large, complex communities, microbes initially cluster into aggregates, and it is unclear if chemical heterogeneity exists in these ubiquitous micrometer-scale aggregates. We chose to examine oxygen availability within an aggregate since oxygen concentration impacts a number of important bacterial processes, including metabolism, social behaviors, virulence, and antibiotic resistance. By determining that oxygen availability can vary within aggregates containing ≤ 10(5) bacteria, we establish that physiological heterogeneity exists within P. aeruginosa aggregates, suggesting that such heterogeneity frequently exists in many naturally occurring small populations.
360497 STUDY ON DETECTION OF SIGNS OF WHEELCLIMB DERAILMENT FOR RAILWAY VEHICLES(Safety,Technical Session) (2009)

This paper presents study on the detection of signs of wheel climb derailment. The sensing method and detecting algorithm were examined. A 1/10-scale model of railway vehicle including one car body and two trucks as well as a special device that can simulate various climb-up derailments only for the chosen wheel are designed and made. Based on experimental derailment tests, sensing method and algorithm for detecting signs of derailment beforehand were proposed. It was found that the peak threshold of pitch angular rate and the integral threshold of roll angular rate of truck flame can be possible to detect of signs derailment.
Cloning and characterisation of a 1.1 kb fragment of the carcinoma-associated epithelial cell adhesion molecule promoter. (2003)

The epithelial cell adhesion molecule (EpCAM) is a transmembrane protein associated with a variety of carcinomas, where EpCAM is often strongly up-regulated or, as in the case of squamous cell carcinomas, de novo expressed. The molecular mechanisms underlying the transcriptional regulation of EpCAM are poorly understood. So far, a 570 bp fragment has been cloned and shown to have specific transcriptional activity, which was negatively-regulated upon the induction of the transcription factor NF-kappa B. In the present study we have cloned a 1100 bp fragment of the EpCAM promoter containing the 570 bp fragment and additional 550 bp upstream. We demonstrate that both fragments have strong synergistic effects with respect to transcriptional activity in EpCAM-positive cells. Furthermore, the 1100 bp fragment was likewise negatively-regulated upon TNF alpha and IFN alpha treatment, thus retaining silencer sequences.
Bidirectional contact tracing could dramatically improve COVID-19 control (2021)

Contact tracing is critical to controlling COVID-19, but most protocols only "forward-trace" to notify people who were recently exposed. Using a stochastic branching-process model, we find that "bidirectional" tracing to identify infector individuals and their other infectees robustly improves outbreak control. In our model, bidirectional tracing more than doubles the reduction in effective reproduction number (R<sub>eff</sub>) achieved by forward-tracing alone, while dramatically increasing resilience to low case ascertainment and test sensitivity. The greatest gains are realised by expanding the manual tracing window from 2 to 6 days pre-symptom-onset or, alternatively, by implementing high-uptake smartphone-based exposure notification; however, to achieve the performance of the former approach, the latter requires nearly all smartphones to detect exposure events. With or without exposure notification, our results suggest that implementing bidirectional tracing could dramatically improve COVID-19 control.
Exploiting the Reaction Flexibility of a Type III Polyketide Synthase through in Vitro Pathway Manipulation (2004)

A synthetic metabolic pathway has been constructed in vitro consisting of the type III polyketide synthase from Streptomyces coelicolor and peroxidases from soybean and Caldariomyces fumago (chloroperoxidase). This has resulted in the synthesis of the pentaketide flaviolin and its dimeric derivative, and a wide range of pyrones and their coupled derivatives with flaviolin, as well as their halogenated derivatives. The addition of acyl-CoA oxidase to the pathway prior to the polyketide synthase resulted in unsaturated pyrone side chains, further broadening the product spectrum that can be achieved. The approach developed in this work, therefore, provides a new model to exploit biocatalysis in the synthesis of complex natural product derivatives.
Electrodeposition Based Synthesis of Metal-Air Battery Cathodes (2014)

Metal air batteries offer the opportunity for unprecedented energy density improvements relative to existing battery technologies. Air cathodes are usually comprised of a catalyst, conductive additives, binder, and current collector. The current collector provides support and conductivity, the binder provides physical adhesion, and the catalyst facilitates the oxygen reduction process at the cathode. Thus, each component plays an important role in the function of the overall electrode. Additionally, access of the catalyst particle to oxygen is critical, so the cathode porosity must be appropriately tuned. Electrodes are often fabricated using physical mixing methods, where issues can include poor interparticle contact and limited access of the interior catalyst particles to oxygen. An electrodeposition based strategy for fabrication of a composite air cathode will be discussed. The first layer consists of a current collector substrate, which can be two dimensional (planar) or three dimensional in design. The second layer consists of a conformal conductive polymer coating. The third layer consists of catalyst particles. The second and third layers are each prepared using stepwise deposition processes. Advantages of the electrodeposition fabrication method will be described. Three-dimensionally structured composites can be easily generated via use of three dimensional substrates. All of the catalyst nanoparticles are positioned on the outer surface of the composite electrode, allowing facile access of oxygen gas molecules to the catalyst particle surfaces. Finally, the conductive polymer provides added conductivity and improved stability to the composite. Resulting impact on conductivity and oxygen reduction activity of the composite electrode will be discussed. References 1. S.H. Lee; S. Zhu; C.C. Milleville; C.-Y. Lee; P. Chen; K.J. Takeuchi; E.S. Takeuchi; A.C. Marschilok. Electrochem. Solid-State Lett. 2010, 13(11), A162-A164. 2. A.C. Marschilok; S. Zhu; C.C. Milleville; S.H. Lee; E.S. Takeuchi; K.J. Takeuchi. J. Electrochem. Soc. 2011, 158(3), A223-A226. 3. A.C Marschilok; S.H. Lee; C.C Milleville; P. Chen; E.S Takeuchi; K.J Takeuchi. J. Composite Materials. 2012, 47(1), 33–40.
Efficient Use of Limited-Memory Accelerators for Linear Learning on\n Heterogeneous Systems (2017)

We propose a generic algorithmic building block to accelerate training of\nmachine learning models on heterogeneous compute systems. Our scheme allows to\nefficiently employ compute accelerators such as GPUs and FPGAs for the training\nof large-scale machine learning models, when the training data exceeds their\nmemory capacity. Also, it provides adaptivity to any system's memory hierarchy\nin terms of size and processing speed. Our technique is built upon novel\ntheoretical insights regarding primal-dual coordinate methods, and uses duality\ngap information to dynamically decide which part of the data should be made\navailable for fast processing. To illustrate the power of our approach we\ndemonstrate its performance for training of generalized linear models on a\nlarge-scale dataset exceeding the memory size of a modern GPU, showing an\norder-of-magnitude speedup over existing approaches.\n
Highly Dispersed Molybdenum Oxycarbide Clusters Supported on Multilayer Graphene for the Selective Reduction of Carbon Dioxide (2021)

Molybdenum oxycarbide clusters are novel nanomaterials that exhibit attractive catalytic activity; however, the methods for their production are currently very restrictive. This work represents a new strategy for the creation of near-subnanometer size molybdenum oxycarbide clusters on multilayer graphene. To adsorb Mo-based polyoxometalates of the type [PMo<sub>12</sub> O<sub>40</sub> ]<sup>3-</sup> as a precursor for Mo oxycarbide clusters, the novel tripodal-phenyl cation N,N,N-tri(4-phenylbutyl)-N-methylammonium ([TPBMA]<sup>+</sup> ) is synthesized. [TPBMA]<sup>+</sup> exhibits superior adsorption on multilayer graphene compared to commercially available cations such as tetrabutylammonium ([nBu<sub>4</sub> N]<sup>+</sup> ) and tetraphenylphosphonium ([PPh<sub>4</sub> ]<sup>+</sup> ). Using [TPBMA]<sup>+</sup> as an anchor, highly dispersed precursor clusters (diameter: 1.0 ± 0.2 nm) supported on multilayer graphene are obtained, as confirmed by high-resolution scanning transmission electron microscopy. Remarkably, this new material achieves the catalytic reduction of CO<sub>2</sub> to selectively produce CO (≈99.9%) via the reverse water-gas-shift reaction, by applying carbothermal hydrogen reduction to generate Mo oxycarbide clusters in situ.
Utilization of Al2O3Atomic Layer Deposition for Li Ion Pathways in Solid State Li Batteries (2014)

Limited interfacial contact area between active material and solid state electrolyte (SSE) in solid state lithium batteries (SSLBs) can be addressed by utilizing a thermally treated Al2O3 atomic layer deposition (ALD) coating as a lithium ion transport pathway. SSLBs with a LiCoO2/Li3.15Ge0.15P0.85S4/77.5Li2S-22.5P2S5/Li configuration were built and tested using charge-discharge cycles between 3.3 ∼ 4.3 V (vs. Li/Li+) at a current density of 45 μA cm−2. An increase of more than 10% in the inital discharge capacity as well as good cycling stability are achieved from SSLBs using LiCoO2 particles coated with 2 and 4 cycles of Al2O3 ALD. The dQ/dV analysis, electrochemical impedance spectroscopy (EIS), and the overpotential study with galvanostatic intermittent titration technique (GITT) were conducted to elucidate the enhancement of Li+ transport through Al2O3 ALD layers surrounding LiCoO2.
Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine (2022)

Coronavirus vaccines that are highly effective against current and anticipated SARS-CoV-2 variants are needed to control COVID-19. We previously reported a receptor-binding domain (RBD)-sortase A-conjugated ferritin nanoparticle (scNP) vaccine that induced neutralizing antibodies against SARS-CoV-2 and pre-emergent sarbecoviruses and protected non-human primates (NHPs) from SARS-CoV-2 WA-1 infection. Here, we find the RBD-scNP induced neutralizing antibodies in NHPs against pseudoviruses of SARS-CoV and SARS-CoV-2 variants including 614G, Beta, Delta, Omicron BA.1, BA.2, BA.2.12.1, and BA.4/BA.5, and a designed variant with escape mutations, PMS20. Adjuvant studies demonstrate variant neutralization titers are highest with 3M-052-aqueous formulation (AF). Immunization twice with RBD-scNPs protect NHPs from SARS-CoV-2 WA-1, Beta, and Delta variant challenge, and protect mice from challenges of SARS-CoV-2 Beta variant and two other heterologous sarbecoviruses. These results demonstrate the ability of RBD-scNPs to induce broad neutralization of SARS-CoV-2 variants and to protect animals from multiple different SARS-related viruses. Such a vaccine could provide broad immunity to SARS-CoV-2 variants.
Reflective Silicon Mach Zehnder Modulator With Faraday Rotator Mirror effect for self-coherent transmission (2013)

An all-Silicon Reflective Mach Zehnder Modulator (Si-R-MZM) is proposed, providing the Faraday Rotator Mirror effect for achieving simple coherent demodulation. The Si-R-MZM is analytically described and measurements are made to assess the transmission performances.
Modification of Ad5 Hexon Hypervariable Regions Circumvents Pre-Existing Ad5 Neutralizing Antibodies and Induces Protective Immune Responses (2012)

The development of an effective malaria vaccine is a high global health priority. Vaccine vectors based on adenovirus type 5 are capable of generating robust and protective T cell and antibody responses in animal models and are currently being evaluated in clinical trials for HIV and malaria. They appear to be more effective in terms of inducing antigen-specific immune responses as compared with non-Ad5 serotype vectors. However, the high prevalence of neutralizing antibodies to Ad5 in the human population, particularly in the developing world, has the potential to limit the effectiveness of Ad5-based vaccines. We have generated novel Ad5-based vectors that precisely replace the hexon hypervariable regions with those derived from Ad43, a subgroup D serotype with low prevalence of neutralizing antibody in humans. We have demonstrated that these hexon-modified adenovectors are not neutralized efficiently by Ad5 neutralizing antibodies in vitro using sera from mice, rabbits and human volunteers. We have also generated hexon-modified adenovectors that express a rodent malaria parasite antigen, PyCSP, and demonstrated that they are as immunogenic as an unmodified vector. Furthermore, in contrast to the unmodified vector, the hexon-modified adenovectors induced robust T cell responses in mice with high levels of Ad5 neutralizing antibody. We also show that the hexon-modified vector can be combined with unmodified Ad5 vector in prime-boost regimens to induce protective responses in mice. Our data establish that these hexon-modified vectors are highly immunogenic even in the presence of pre-existing anti-adenovirus antibodies. These hexon-modified adenovectors may have advantages in sub-Saharan Africa where there is a high prevalence of Ad5 neutralizing antibody in the population.
Ballistic dispersion in temperature gradient focusing (2007)

Molecular dispersion is caused by both molecular diffusion and non-uniform bulk fluid motion. While the Taylor–Aris dispersion regime is the most familiar regime in microfluidic systems, an oft-overlooked regime is that of purely kinematic (or ballistic) dispersion. In most microfluidic systems, this dispersion regime is transient and quickly gives way to Taylor–Aris dispersion. In electrophoretic focusing methods such as temperature gradient focusing (TGF), however, the characteristic time scales for dispersion are fixed, and focused peaks may never reach the Taylor limit. In this situation, generalized Taylor dispersion analysis is not applicable. A heuristic model is developed here which accounts for both molecular diffusion and advective dispersion across all dispersion regimes, from pure diffusion to Taylor dispersion to pure advection. This model is compared to results from TGF experiments and accurately captures both the initial decrease and subsequent increase in peak widths as electric field strength increases. The results of this combined analytical and experimental study provide a useful tool for estimation of dispersion and optimization of TGF systems.
Successful Catheter Ablation of Atrial Fibrillation (1994)

Successful catheter ablation of human atrial fibrillation is feasible using linear atrial lesions created by radiofrequency energy delivery. Further studies are mandatory to ascertain the efficacy and safety of this procedure, as well as to assess different catheter techniques.