gebhart/patrepeval huggingface dataset:
The WAF 1-mediated p53 growth-suppressor pathway is intact in the coronary arteries of heart transplant recipients (1996)

It has been suggested that the interaction of cytomegalovirus (CMV) with the p53 tumor suppressor gene product plays a role in the development of coronary artery restenosis after angioplasty. CMV nucleic acids have been observed in the coronary arteries of allografted hearts, suggesting a possible role for the interaction of CMV with p53 in the development of accelerated graft arteriosclerosis in transplant recipients. Formalin-fixed, paraffin-embedded sections of coronary arteries from 19 transplanted hearts were immunostained for the p53 gene product using Target Unmasking Fluid (TUF)-mediated immunohistochemistry and the anti-p53 antibodies CM1 and DO7. Fresh-frozen sections of coronary arteries were also available from six of the 19 hearts, and these fresh-frozen sections were immunostained for the p53 gene product with the DO7 antibody and for WAF1 using the anti-WAF1 antibody EA10. Focal and weak staining for p53 was observed in smooth muscle and endothelial cells in two of 19 vessels, whereas the remaining 17 did not stain. CMV nucleic acids were previously shown in six of 13 of these hearts by in situ hybridization. The fresh-frozen sections of coronary arteries also did not stain for p53, but the smooth muscle cells in these vessels did stain intensely for WAF1. These results suggest three possibilities: (1) CMV-p53 interactions are not important in the development of accelerated graft arteriosclerosis; or (2) there is an interaction, but it is transient and not detectable at the time points examined in this study; or (3) there is an interaction, but binding of CMV to p53 leads to accelerated degradation of p53, as occurs with HPV-E6. The expression of WAF1 further suggests that the WAF1-mediated antiproliferative signal is intact in these vessels.
Serial Urinary 11-Dehydrothromboxane B2, Aspirin Dose, and Vascular Events in Blacks After Recent Cerebral Infarction (2004)

Fluctuations in urinary 11-DTB2 after cerebral infarction in blacks do not correlate with changes in aspirin doses, except perhaps when the dose changes by a factor of 4 or more. A larger study is needed to look further for aspirin resistance.
Targeting HER3 mRNA by a locked nucleic antisense molecule enhances the antitumor activity of gefitinib in vivo (2011)

Human tumor cells were treated with LNA-ONs without lipofection at the various concentrations. Cell proliferation was examined by MTS assay. The optical densities were measured in a Microplate Reader (Molecular Devices, Sunnyvale, CA, USA) at a wavelength of 490 nm. EZN-3920 was chosen because of its potency and selectivity among tested HER3+ tumor cell lines. Cell proliferation (MTS), mRNA (qRT-PCR), and protein (western blot) examinations were performed 3-5 days after drug incubation.
Assessment of a constraint-based routing algorithm for translucent 10Gbits/s DWDM networks considering fiber nonlinearities (2008)

We present a constraint-based routing (CBR) approach for real-time operation considering both linear as well as nonlinear signal quality degrading effects in a heterogeneous network infrastructure. Different novel routing algorithms are assessed regarding their blocking probabilities. Furthermore, regenerator pools are placed at a limited number of nodes selected by a heuristic algorithm taking into account the physical impairments. It is shown that CBR together with intelligent regenerator placement can decrease the blocking probability significantly.
TransFORMing Feedback to TransFORM Learning (2020)

The importance and value of formative feedback and assessment for learning are well-attested in the literature (Black &amp; Wiliam, 2006; Hattie &amp; Timperley, 2007; Nicol, 2010; Nicol, Thomson &amp; Breslin, 2014). In this presentation we will describe how we have transformed our approach to feedback through the design of constructively aligned formative tasks in preparation for assessments. These include approaches to engage students with formative feedback, that is feedback for learning. We will also present the findings of a staff-student collaborative evaluation of these approaches providing valuable insights into the students’ perceptions of assessment for learning. The MEd and MSc TESOL programmes, a small and small-medium masters, are professionally oriented and cater to a range of student profiles. Many are new to HE in the UK, some are returning after a considerable time away from study, and all need to be able to negotiate the diverse assessment requirements. As 1-year PGT students, this transition needs to happen in a compressed time period. Drawing from our background in education and language teaching, we have implemented a variety of ways to scaffold students in preparing for summative assessments. This ‘front loading’ of feedback encourages reflection along with a focus on the process of learning and has increasingly incorporated assignment familiarization tasks and peer feedback, partly to engage students with criteria and promote active learning and partly as a response to growing numbers. The programmes receive very good evaluations in PTES and course evaluations for assessment and feedback but these only provide a general picture. We present findings of a staff-student evaluation of the approaches to feedback for learning, in order to provide a better understanding of what works and what is less effective. The approaches discussed in the presentation can be applied to a wide range of courses.
Sinonasal Leiomyosarcoma: Review of Literature and Case Report (2005)

The prognosis for primary sinonasal leiomyosarcomas is poor. However, a 10-year survival has been reported in a few patients. Chemotherapy may be a useful adjunct when managing extensive lesions unamenable to curative resection.
Randomized Placebo-/Sham-Controlled Trials of Spinal Cord Stimulation: A Systematic Review and Methodological Appraisal (2019)

To date the methods of placebo/sham control and blinding in RCTs have been poorly reported, leading to concerns about the validity and replicability of the findings. Important aspects that need to be clearly reported in the design of placebo-/sham-controlled RCTs of SCS include the transparent reporting of stimulation programming parameters, patient position during perception threshold measurement, management of the patient handheld programmer, frequency of recharging, and assessment of the fidelity of blinding.
Properties of epitaxial BaTiO3 deposited on GaAs (2013)

Single crystal BaTiO3 (BTO) has been grown epitaxially on GaAs using molecular beam epitaxy with a 2 unit cell SrTiO3 nucleation layer. The oxide film is lattice-matched to GaAs through an in-plane rotation of 45° relative to the (100) surface leading to c-axis orientation of the BaTiO3. X-ray diffraction confirmed the crystallinity and orientation of the oxide film with a full width half maximum of 0.58° for a 7.5 nm thick layer. Piezoresponse force microscopy was used to characterize the ferroelectric domains in the BaTiO3 layer, and a coercive voltage of 1–2 V and piezoresponse amplitude ∼5 pm/V was measured.
A human–machine interaction strategy function: information throughput and weighting with application to Multiple-Attribute-Task-Battery (2012)

The Multiple-Attribute-Task-Battery (MATB) displays five independent and concurrent tasks to which a human operator (HO) responds. MATB records the task-specific responses and so provides data on human performance. A general strategy function based on five task-specific strategy cases is described to characterise the human–MATB interaction. A prior report evaluated an implicit strategy group of 32 HOs for whom no strategy-important information was provided (i.e. all tasks are equally important). However, a specified strategy function did not characterise the group. This report evaluates an explicit strategy group of 35 HOs for whom the actual weighting of the five tasks was provided. The general strategy function is applied to both groups and characterises two different strategies. With respect to ergonomic theory and practice, a generalised strategy function is defined and applied to the human–MATB interaction that characterises two different strategy types and also provides a metric for MATB system complexity across five independent tasks.
Acoustic anomalies at the improper ferroelastic phase transition of p-terphenyl (1984)

Abstract Modifications of the elastic properties of p-terphenyl (C18H14) have been studied by Brillouin scattering from room temperature down to 80 K. The more important effect produced by this transition at 193 K is the appearance of 3 new elastic constants and it can be explained by a coupling quadratic both in deformation and order parameter.
UWB MIMO Antenna for High Speed Wireless Applications (2019)

The paper proposes a MIMO antenna composed of two elements in the form of UWB monopole antennas. Polarization diversity of the proposed antenna is obtained locating the two elements perpendicularly on a common substrate. Also the isolation between elements is accomplished without using any extra decoupling structures. The two monopoles antennas with half elliptical shape are fed with asymmetric coplanar strip (ACS). The presented antenna is located on substrate 48 × 28 mm2 in total size. The distance between the two elements is 15 mm that is 0.15λ0 at 3GHz. The antenna was designed to work effectively from 3 to 11.5 GHz with reflection coefficient better than -10 dB and isolation lower than 18 dB. In addition, antenna with elements located in parallel was designed to show the advantage of the original design. Envelope correlation coefficient, diversity gain and channel capacity loss document the antennas behavior. The antenna was fabricated and measured. Measurement validated the simulation and showed that the designed antenna can be well applied in UWB MIMO systems.
The influence of HCl on the evaporation rates of H 2 O over water ice in the range 188 to 210 K at small average concentrations (2018)

Abstract. The evaporation flux Jev(H2O) of H2O from HCl-doped typically 1.5 µm or so thick vapor-deposited ice films has been measured in a combined quartz crystal microbalance (QCMB)–residual gas mass spectrometry (MS) experiment. Jev(H2O) has been found to show complex behavior and to be a function of the average mole fraction χHCl of HCl in the ice film ranging from 6×1014 to 3×1017 molecule cm−2 s−1 at 174–210 K for initial values χHCl0 ranging from 5×10-5 to 3×10-3 at the start of the evaporation. The dose of HCl on ice was in the range of 1 to 40 formal monolayers and the H2O vapor pressure was independent of χHCl within the measured range and equal to that of pure ice down to 80 nm thickness. The dependence of Jev(H2O) with increasing average χHCl was correlated with (a) the evaporation range rb∕e parameter, that is, the ratio of Jev(H2O) just before HCl doping of the pure ice film and Jev(H2O) after observable HCl desorption towards the end of film evaporation, and (b) the remaining thickness dD below which Jev(H2O) decreases to less than 85 % of pure ice. The dependence of Jev(H2O) with increasing average χHCl from HCl-doped ice films suggests two limiting data sets, one associated with the occurrence of a two-phase pure ice/crystalline HCl hydrate binary phase (set A) and the other with a single-phase amorphous HCl∕H2O binary mixture (set B). The measured values of Jev(H2O) may lead to significant evaporative lifetime extensions of HCl-contaminated ice cloud particles under atmospheric conditions, regardless of whether the structure corresponds to an amorphous or crystalline state of the HCl∕H2O aggregate.
Apparent Digestibility Coefficient of Housefly Maggot Meal (magmeal) for Nile Tilapia (Oreochromis niloticus L.) and Carp (Cyprinus carpio) (2010)

To evaluate the digestibility of house fly maggot meal (magmeal) formulated reference diet (containing fishmeal as primary protein source) and a test diet (containing 70% reference diet + 30% maggot meal) were fed to triplicate groups of tilapia and carp with initial average body weights of 108.332 and 110.323 g, respectively. Faeces were collected over a period of 15 days by siphoning. The apparent digestibility coefficients (ADCs) of magmeal calculated for tilapia (dry matter: 47.65%, crude protein: 57.7%, crude fat: 86.1%; gross energy: 58.1%) were significantly lower than that for carp (dry matter: 63.84%, crude protein: 84.9%, crude fat: 96
Adaptive energy management features of the POWER7TM processor (2010)

Provides a collection of slides covering the following: POWER7 EnergyScale goals; EnergyScale primary policies; POWER7 features; energy savings; per-core frequency scaling; EnergyScale impact; autonomic EnergyScale features; autonomic frequency reduction; processor core power proxy; and dynamic guardbanding.
Soft-Prioritization Based System Selection Strategy for Software Defined Radio (2005)

The next-generation wireless networks will bring users with Software Defined Radio (SDR) terminals seamless mobility and ubiquitous computing through heterogeneous networks. This paper proposes a soft-prioritization based system selection algorithm performed by SDR terminal and investigates the effectiveness of the soft-prioritization based system selection by using a concrete simulation model. To maximize the quality of service (QoS), wireless communication systems are prioritized on the basis of criteria for system selection such as data rate, channel quality and cost, and should be dynamically changed. However, frequent inter-system handovers based on hard-prioritization are undesirable in view of interrupting and dropping, particularly for real-time traffic and managing channel capacities. Wireless communication systems are softly prioritized in the soft-prioritization based system selection algorithm, and therefore inter-system handovers between systems with the same priority aren't initiated. To elucidate the validity of the soft-prioritization based system selection algorithm, a system simulation model consisting of five wireless communication systems is employed. Simulation results confirm that the soft-prioritization system selection algorithm offers higher performance in terms of the number of inter-system handovers and throughput of best effort traffic.
MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3 (2010)

The molecules that regulate the apoptosis cascade are also involved in differentiation and syncytial fusion in skeletal muscle. MyoD is a myogenic transcription factor that plays essential roles in muscle differentiation. We noticed that MyoD(-/-) myoblasts display remarkable resistance to apoptosis by down-regulation of miR-1 (microRNA-1) and miR-206 and by up-regulation of Pax3. This resulted in transcriptional activation of antiapoptotic factors Bcl-2 and Bcl-xL. Forced MyoD expression induces up-regulation of miR-1 and miR-206 and down-regulation of Pax3, Bcl-2, and Bcl-xL along with increased apoptosis in MyoD(-/-) myoblasts. In contrast, MyoD gene knockdown increases cell survival of wild-type myoblasts. The 3' untranslated region of Pax3 mRNA contains two conserved miR-1/miR-206-binding sites, which are required for targeting of these microRNAs (miRNAs). Therefore, these data suggest that MyoD not only regulates terminal differentiation but also apoptosis through miRNA-mediated down-regulation of Pax3. Finally, MyoD, miR-1, and miR-206 are all down-regulated in quiescent satellite cells, which may be required for maintenance of muscle stem cells.
Low-profile high-sensitivity sub-array module with HTS filters for an active phased array antenna (2014)

We have developed a low-profile high-sensitivity sub-array module for an active phased array antenna. By using this sub-array module, a low noise receiving antenna can be easily available for wireless applications such as radar systems, communication systems, and so on. In this paper, we describe the new 16 elements S-band multichannel receiving sub-array module using high-temperature superconducting (HTS) filters as a key component for an active phased array antenna. Each receiving channel correspond to an antenna element consists of a HTS filter, a low noise amplifier (LNA), and interface circuits. In the sub-array module, 16 channel circuits are contained within a 200 mm×240 mm×30 mm vacuum chamber and cooled by a small cooler to 77 K. By using HTS filters and the cooler, feed-line loss and internal noise can be substantially reduced. Therefore, high sensitivity for an active phased array antenna can be realized. Additionally, radio wave interferences can be suppressed effectively by sharp frequency selectivity of the HTS filter with high-Q factor.
Common Ancestor Objective Function and Parent Set DAG Metric Container Extension (2020)

Implementing Packet Replication and Elimination from/to the RPL root requires the ability to forward copies of packets over different paths via different RPL parents. Selecting the appropriate parents to achieve ultra-low latency and jitter requires information about a node's parents. This document details what information needs to be transmitted and how it is encoded within RPL control packets to enable this functionality. This document also describes Objective Function which take advantage of this information to implement multi-path routing. Status of This Memo This Internet-Draft is submitted in full conformance with the provisions of BCP 78 and BCP 79.
Fasting and prolonged food restriction differentially affect GH secretion independently of GH receptor signaling in AgRP neurons (2023)

Growth hormone (GH) receptor (GHR) is abundantly expressed in neurons that co-release the agouti-related protein (AgRP) and neuropeptide Y (NPY) in the arcuate nucleus of the hypothalamus (ARH). Since ARH<sup>AgRP/NPY</sup> neurons regulate several hypothalamic-pituitary-endocrine axes, this neuronal population possibly modulates GH secretion via a negative feedback loop, particularly during food restriction, when ARH<sup>AgRP/NPY</sup> neurons are highly active. The present study aims to determine the importance of GHR signaling in ARH<sup>AgRP/NPY</sup> neurons on the pattern of GH secretion in fed and food-deprived male mice. Additionally, we compared the effect of two distinct situations of food deprivation: 16 h of fasting or four days of food restriction (40% of usual food intake). Overnight fasting strongly suppressed both basal and pulsatile GH secretion. Animals lacking GHR in ARH<sup>AgRP/NPY</sup> neurons (AgRP<sup>∆GHR</sup> mice) did not exhibit differences in GH secretion either in the fed or fasted state, compared to control mice. In contrast, four days of food restriction increased GH pulse frequency, basal GH secretion, and pulse irregularity/complexity (measured by sample entropy), whereas pulsatile GH secretion was not affected in both control and AgRP<sup>∆GHR</sup> mice. Hypothalamic Ghrh mRNA levels were unaffected by fasting or food restriction, but Sst expression increased in acutely fasted mice, but decreased after prolonged food restriction in both control and AgRP<sup>∆GHR</sup> mice. Our findings indicate that short-term fasting and prolonged food restriction differentially affect the pattern of GH secretion, independently of GHR signaling in ARH<sup>AgRP/NPY</sup> neurons.
Identical 371-Base-Pair Deletion Mutations in the LAT Genes of Herpes Simplex Virus Type 1 McKrae and 17syn+ Result in Different In Vivo Reactivation Phenotypes (1999)

The herpes simplex virus type 1 (HSV-1) LAT gene is the only viral gene abundantly transcribed during latency. LAT null mutants created with strains McKrae and 17syn+ are impaired for both in vivo spontaneous and in vivo-induced reactivation. Thus, LAT is essential for efficient in vivo-induced and spontaneous reactivation. Different investigators have studied two LAT mutants containing a StyI-StyI region deletion corresponding to LAT nucleotides 76 to 447. One mutant, dLAT371 (parent strain, McKrae), had parental high frequencies of spontaneous reactivation. In vivo-induced reactivation was not examined. The other mutant, 17DeltaSty (parent strain, 17syn+), had parental frequencies of in vitro reactivation following cocultivation of explanted ganglia but reduced frequencies of in vivo-induced reactivation. Spontaneous reactivation frequency was not reported for 17DeltaSty. These combined results suggested the possibility that in vivo spontaneous reactivation and in vivo-induced reactivation may map to different regions within the LAT domain. We now report that dLAT371 has in vivo-induced reactivation frequencies of the parent and that 17DeltaSty has reduced frequencies of in vivo spontaneous reactivation. Thus, dLAT371 demonstrated the parental phenotype for both in vivo spontaneous and -induced reactivation while the apparently identical 17DeltaSty was impaired for both in vivo spontaneous and -induced reactivation. These results suggest that one or more differences between the genetic backgrounds of McKrae and 17syn+ result in different in vivo reactivation phenotypes of otherwise identical deletion mutations and that McKrae may have compensating sequences sufficient to overcome the loss of the StyI-StyI region of the LAT transcript.
Endovascular Grafting Techniques (2000)

History, Potential Influence, and Facility Requirements of Transluminally Placed Endovascular Grafts The Role of Arteriography in Endovascular Grafting Techniques The Role of Helical CT-Angiography in Endovascular Application of Magnetic Resonance Angiography of an Aortic Phantom to Determine the Lumen Length of an Abdonimal Aortic Aneurysm ultrasound Imaging Techiniques for Evaluation of Transluminally Placed Endovascular Grafts Color Duplex Ultrasound Evaluation of Endovascular Stented Graft Aortic Aneurysm Repair Anatomic Varations of Abdominal Aortic Aneurysms Stent-Graft Combination:A New Technique for the Treatment of Aneurysms Transfemoral Endovascular Repair of Abdominal Aortic Aneurysms:Feasibility Study of the EGS System The Nottingham Experience with Endovascular Repair of Abdominal Aortic Aneurysms Endovascular Management of Descending Thoracic Aortic Aneurysms Endovascular Grafts for Vascular Injuries Endovascular Grafting for Aortoiliac Occlusive Disease Endoluminal Grafting for Femoropopliteal Occlusive Disease Endovascular Stented Grafts: An Independent View Development of a Program of Endoluminal Aneurysm Repair:Experience in 250 Patients Inde
Histiocytosis-X (1981)

Twelve of 17 patients with histiocytosis-X were immunologically abnormal, as shown by the presence of circulating lymphocytes spontaneously cytotoxic to cultured human fibroblasts or of antibody to autologous erythrocytes. The patients also had a notable lack of histamine H2 surface receptors on their T lymphocytes, suggesting a suppressor-cell deficiency. The lymphocyte abnormalities were reversed in vitro after incubation in a crude extract of calf thymus gland, and therefore all 17 patients were treated with daily intramuscular injections of this extract. With this therapy, 10 patients entered complete remission -- a response at least as good as that observed in historical controls treated with chemotherapy. A positive clinical response was associated with an increase in the number of T-cell histamine H2 receptors to normal levels and with correction of the other immunologic abnormalities. The results of this preliminary study justify a larger prospective clinical trial of thymic extract and further investigation of the immunoregulatory mechanisms in histiocytosis-X.