gebhart/patrepeval huggingface dataset:
Studies on the molecular association of oxytocin and related compounds in dimethyl sulfoxide (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on the molecular association of oxytocin and related compounds in dimethyl sulfoxideJean P. Meraldi and Victor J. HrubyCite this: J. Am. Chem. Soc. 1976, 98, 20, 6408–6410Publication Date (Print):September 1, 1976Publication History Published online1 May 2002Published inissue 1 September 1976https://pubs.acs.org/doi/10.1021/ja00436a069https://doi.org/10.1021/ja00436a069research-articleACS PublicationsRequest reuse permissionsArticle Views32Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Direct Electron Transfer Between Ligninolytic Redox Enzymes and Electrodes (2004)

Abstract The electrochemistry of the ligninolytic redox enzymes, which include lignin peroxidase, manganese peroxidase and laccase and possibly also cellobiose dehydrogenase, is reviewed and discussed in conjunction with their basic biochemical characteristics. It is shown that long‐range electron transfer between these enzymes and electrodes can be established and their ability to degrade lignin through a direct electron transfer mechanism is discussed.
Controlling spontaneous emission rate in solid state for quantum information science (2005)

We enhance and suppress the excitonic lifetime of an InAs quantum dot (QD) by modifying its alignment with a resonance cavity in a photonic crystal slab. The QD/cavity system has applications in quantum information science.
Reduced membrane fluidity of a SigX deficient strain results in altered carboncatabolic repression response in Pseudomonas aeruginosa (2017)

International audience
Generating Expository Dialogue from Monologue: Motivation, Corpus and Preliminary Rules (2010)

Generating expository dialogue from monologue is a task that poses an interesting and rewarding challenge for Natural Language Processing. This short paper has three aims: firstly, to motivate the importance of this task, both in terms of the benefits of expository dialogue as a way to present information and in terms of potential applications; secondly, to introduce a parallel corpus of monologues and dialogues which enables a data-driven approach to this challenge; and, finally, to describe work-in-progress on semi-automatic construction of Monologueto-Dialogue (M2D) generation rules.
Relationship of Messenger RNA Reverse Transcriptase–Polymerase Chain Reaction Signal to Campylobacter spp. Viability (2004)

SUMMARY. Discriminating viable from dead cells is of importance in the development of bacterial detection methods. A positive reverse transcriptase-polymerase chain reaction (RT-PCR) amplification signal was tested as a potential predictor of chick colonization. Some researchers have suggested that the presence of messenger RNA (mRNA) may not correlate with cell viability. Chicken colonization by cells that have positive mRNA signal but that are noncultivable would provide a correlation in cell viability and persistence of mRNA. The role of a viable but noncultivable (VBNC) form of Campylobacter spp. for colonization of poultry could be verified by such an mRNA signal. The levels of four strains of Campylobacter spp., previously isolated from poultry feces, declined progressively over time, and loss of cultivability occurred after 6 to 7 wk incubation in phosphate-buffered saline (PBS) at 4 C. Cold-stored, noncultivable and heat-inactivated (60 C for 10 min) Campylobacter spp. produced inconsistent amplified products from RT-PCR assay, depending on the target transcripts and strains used, although all fresh cultures showed mRNA signals. For the most part, signals of mRNA species from VBNC and heat-killed Campylobacter spp. AH-1, AH-2, and CH-3 persisted. RT-PCR amplification of transcripts originating from the tkt and cmp genes and a 256-base pair amplicon (from a previously described putative haem-copper oxidase) provided consistent signals, whereas transcripts from the flaA gene did not. Presumed VBNC and heat-inactivated Campylobacter spp., which produced positive mRNA signal but was not cultivable by conventional culture-based methods, did not establish colonization in the intestine of chicks 7 days after challenge. These results lead us to question the correlation between mRNA durability with cell viability as well as the significance of the VBNC cells in environmental transmission of Campylobacter spp.
The role of progesterone and GABA in PMS/PMDD (2007)

The relationship between the luteal phase of the menstrual cycle and symptom development in premenstrual dysphoric disorder/premenstrual syndrome (PMDD/ PMS) is self-evident. Symptoms starts after ovulation and then increase in parallel with the rise in serum progesterone during the luteal phase. The symptom severity reaches a peak during the last five premenstrual days or the first day of menstruation. Thereafter, the symptoms decline and disappear 3-4 days after the onset of menstrual bleeding. During the postmenstrual phase there is a period of well-being, closely following estrogen production, to the estradiol peak. This suggests that there is a symptom-provoking factor produced by the corpus luteum of the ovary.1 This is further supported by the fact that in anovulatory cycles, spontaneous or induced, when a corpus luteum is not formed, no symptom cyclicity occurs.2-4Further evidence that progesterone and progestogens induce negative mood symptoms similar to those in PMDD/PMS is seen in postmenopausal women receiving estrogen/progesterone hormone therapy.5-7 As discussed above, there are strong indications that steroids from the corpus luteum are the symptom-provoking factor in the central nervous system (CNS). But the classical hormonal receptor for progesterone seems not to be involved in the pathophysiology of PMS/PMDD; treatment with the progesterone receptor antagonistmifepristone (RU-486) fails to reduce the physical or behavioral manifestations of PMS.8
Cell assay using a two-photon-excited europium chelate (2011)

We report application of two-photon excitation of europium chelates to immunolabeling of epidermal growth factor receptor (EGFR) cell surface proteins on A431 cancer cells. The europium chelates are excited with two photons of infrared light and emit in the visible. Europium chelates are conjugated to antibodies for EGFR. A431 (human epidermoid carcinoma) cells are labeled with this conjugate and imaged using a multiphoton microscope. To minimize signal loss due to the relatively long-lived Eu(3+) emission, the multiphoton microscope is used with scanning laser two-photon excitation and non-scanning detection with a CCD. The chelate labels show very little photobleaching (less than 1% during continuous illumination in the microscope for 20 minutes) and low levels of autofluorescence (less than 1% of the signal from labeled cells). The detection limit of the europium label in the cell assay is better than 100 zeptomoles.
Effects of tumor necrosis factor-alpha on peroxidation of plasma lipoprotein lipids in experimental animals and patients (1992)

Changes in the plasma lipid composition are observed in patients and animals with malignancy and certain other diseases that are consistent with peroxidation of plasma lipoprotein lipids. These changes can be observed with water-suppressed proton (H-1) and carbon-13 (C-13) nuclear magnetic resonance spectroscopy (NMR) and gas chromatography. Gas chromatography provides evidence of a decrease in polyunsaturated fatty acids relative to monounsaturated fatty acids. This evidence is consistent with that observed by C-13 NMR spectroscopy. Mediators for these effects were sought. Cytokines, known to be released in response to malignant tumor cells and to affect lipid metabolism, were injected into normal mice and their effects on the H-1 and C-13 NMR spectra of plasma lipids were observed. Mouse recombinant tumor necrosis factor-alpha (mr-TNF-alpha) significantly decreased the H-1 methyl and methylene lipid linewidths, and the C-13 spectra indicated a decrease in the relative concentration of polyunsaturated fatty acids. The same changes were directly confirmed by gas chromatographic analysis, showing decreases in the amount of linoleic and arachidonic acids and other polyunsaturated fatty acids relative to monounsaturated fatty acids and in the ratio of polyunsaturated to monounsaturated fatty acids. Serial plasma samples from volunteers receiving an infusion of endotoxin showed similar changes in their C-13 NMR spectroscopy at times when peak TNF-alpha values were measured. In addition, in these samples the C-13 NMR spectra showed direct evidence of lipid peroxidation products. These changes were similar to those observed commonly in the plasma of cancer patients. Other cytokines (human recombinant interleukin-1 alpha [hr-IL-1 alpha], hr-IL-2, mouse recombinant interferon-gamma) did not produce these effects. We conclude that TNF-alpha is a mediator (but not necessarily the only one) of changes in plasma lipoprotein lipid composition due to peroxidation and that this is a mechanism for the changes observed in the NMR spectra of plasma from cancer patients and from normal animals injected with TNF-alpha.
Use of an Osteoinductive Biomaterial (rhOP-1) in Healing Large Segmental Bone Defects (1998)

The results indicate that osteoinductive materials, which have the ability to quickly fill and heal large defects, may have advantages over osteoconductive materials, which are typically used to fill smaller non-load-bearing bone voids.
Diminishing Apoptosis by Deletion of Bax or Overexpression of Bcl-2 Does Not Protect against Infectious Prion ToxicityIn Vivo (2007)

B-cell lymphoma protein 2 (Bcl-2) and Bcl-2-associated X protein (Bax), key antiapoptotic and proapoptotic proteins, respectively, have important roles in acute and chronic models of neurologic disease. Several studies have implicated Bax and Bcl-2 in mediating neurotoxicity in prion diseases. To determine whether diminishing apoptotic cell death is protective in an infectious prion disease model we inoculated mice that either were null for proapoptotic Bax or overexpressed antiapoptotic Bcl-2. Interestingly, genetic manipulation of apoptosis did not lessen the clinical severity of disease. Moreover, some disease parameters, such as behavioral alterations and death, occurred slightly earlier in mice that are null for Bax or overexpress Bcl-2. These results suggest that Bax and Bcl-2 mediated apoptotic pathways are not the major contributing factor to the clinical or pathological features of infectious prion disease.
Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant (1995)

The Inositol 1,4,5-trisphosphate receptor (IP3R) is an intracellular calcium channel involved in coupling cell membrane receptors to calcium signal transduction pathways within the cell. We have cloned a cDNA for the human type 1 inositol 1,4,5-trisphosphate receptor. The sequence contains the S2 splice site which appears to be the region most divergent between rat and human. We now report an additional alternatively spliced region in the coupling domain, that is 9 amino acids long, which we term S3. Alternatively spliced forms are found in both human and rat. PCR analysis of brain and peripheral tissues from human and rat shows both transcripts of the type 1 inositol 1,4,5-trisphosphate receptor in all tissues. The long form predominates in most brain regions (except the cerebellum) while the short form predominates in peripheral tissues. The sequence of the longer form in human appears to create an additional consensus protein kinase C phosphorylation site.
Obatoclax, Saliphenylhalamide, and Gemcitabine Inhibit Influenza A Virus Infection (2012)

Influenza A viruses (IAVs) infect humans and cause significant morbidity and mortality. Different treatment options have been developed; however, these were insufficient during recent IAV outbreaks. Here, we conducted a targeted chemical screen in human nonmalignant cells to validate known and search for novel host-directed antivirals. The screen validated saliphenylhalamide (SaliPhe) and identified two novel anti-IAV agents, obatoclax and gemcitabine. Further experiments demonstrated that Mcl-1 (target of obatoclax) provides a novel host target for IAV treatment. Moreover, we showed that obatoclax and SaliPhe inhibited IAV uptake and gemcitabine suppressed viral RNA transcription and replication. These compounds possess broad spectrum antiviral activity, although their antiviral efficacies were virus-, cell type-, and species-specific. Altogether, our results suggest that phase II obatoclax, investigational SaliPhe, and FDA/EMEA-approved gemcitabine represent potent antiviral agents.
Toward Understanding Preferences for Sharing and Privacy (2004)

E-commerce has spawned a growing concern and discussion about privacy. Similar concerns about privacy are emerging with ubiquitous computing applications that sense and report one’s location and activity. But sharing is as important as privacy; work and social interaction are more efficient when people share some information with some recipients. Unfortunately, commonly available tools for specifying who can see what have been too complex and tedious for most computer users. We report on studies of preferences about privacy and sharing aimed at identifying fundamental concerns with privacy and at understanding how people might abstract the details of sharing into higher-level classes of recipients and information that people tend to treat in a similar manner. To characterize such classes, we collected information about sharing preferences, recruiting 30 people to specify what information they are willing to share with whom. Although people vary in their overall level of comfort in sharing, we discovered key classes of recipients and information. Such abstractions highlight the promise of developing simpler, more expressive controls for sharing and privacy. Author Keywords Information sharing, privacy, perceptions of trust
Finite element simulation of TT cut torsional quartz crystal resonators (2002)

This paper describes a vibration analysis of TT cut torsional quartz crystal resonators of tuning fork-type with finite element method. The influence upon vibrations of vibrational portions due to a shape and a dimension of the supporting portion which is connected to two lead wires is clarified for the fundamental mode vibrating in torsion. As a result, the shape and the dimension of the supporting portion are found to give the great influence on various characteristics, and also an optimum designed resonator is provided.
Nitroxide Radicals for Highly Efficient Redox Mediation in Dye-sensitized Solar Cells (2010)

Abstract A robust nitroxide radical, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and its 4-subsituted derivatives (R-TEMPO) exhibit electrochemically reversible redox properties with tunable half-wave potentials (E1/2) based on the substituent effect. Dye-sensitized solar cells using R-TEMPO as mediators with electron-withdrawing R groups showed significantly enhanced photovoltages compared with those obtained using iodides. The linearity between the open-circuit voltage (Voc) and E1/2 revealed that Voc was dominated by the energy gap between the Fermi level of TiO2 and the SOMO level of R-TEMPO.
Second neoplasms in patients with Hodgkin's disease following combined modality therapy--the Yale experience. (1986)

From 1969 to 1982, 183 patients with previously untreated stages IIIB and IV Hodgkin's disease and relapsing Hodgkin's disease after radiation therapy were treated with combination chemotherapy plus low-dose irradiation (CRT). One hundred fifty patients who achieved a complete response (CR) were analyzed for risk of developing a second neoplasm. Median follow-up has been 8.3 years. Actuarial survival of all patients is 74% at 10 years with a relapse-free survival of 68%. An additional 24 patients with stage IIIA disease were also treated with CRT. There were 22 CRs at risk who were analyzed. Median follow-up has been 3+ years with an actuarial survival of 90% at five years and a relapse-free survival of 83%. Second neoplasms have developed in 14 of 172 patients at risk: acute nonlymphocytic leukemia (ANLL; five patients); aggressive histology non-Hodgkin's lymphoma (NHL; three patients); and a variety of solid neoplasms (six patients). Time to second neoplasm diagnosis after initial treatment ranged from 12 to 141 months. Five patients were older than 40 years. At the time of diagnosis of the second malignancy, 11 patients were free of Hodgkin's disease (for 36 to 141 months) and three were receiving therapy for recurrent Hodgkin's disease. The 10-year actuarial risk (%) of developing ANLL was 5.9 +/- 2.8; for NHL, the risk was 3.5 +/- 2.4, and for solid neoplasms, 5.8 +/- 3.0. Our results suggest that combination chemotherapy plus low-dose irradiation does not appear to significantly increase the risk of developing second neoplasms above that already reported for combination chemotherapy when administered as either initial or salvage treatment of Hodgkin's disease.
Supplementary Figure 6 from Tumor-Specific CD8<sup>+</sup> T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts (2023)

Supplementary Figure 6 from Tumor-Specific CD8&lt;sup&gt;+&lt;/sup&gt; T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts
Fast continuous path tracking control considering high precision and torque saturation (2009)

Continuous path tracking control is an important technology for the position control system such as factory automation field. Particularly, large acceleration and/or deceleration torque is required for continuous path tracking control at its start position and its goal position. Each AC servo motor of continuous path tracking control has limitation of current and voltage. Therefore, in controlling a multi-degree-of-freedom continuous path tracking control system, even if only the motor torque of one axis has the current limitation, the actual position response is not often equal to the desired trajectory reference. In fast continuous path tracking control of multi-degree-of-freedom position control system, the position error sometimes increases according to the unknown disturbance torque and inertia variation. In order to overcome these problems, this paper proposes a new continuous path tracking control algorithm by considering both the torque saturation and the coordinated motion. The proposed method assures the coordinated motion by considering the torque limitation. The effectiveness of the proposed method is confirmed by the experimental results in this paper.
Genotypic Profile ofStreptococcus suisSerotype 2 and Clinical Features of Infection in Humans, Thailand (2011)

To examine associations between clinical features of Streptococcus suis serotype 2 infections in humans in Thailand and genotypic profiles of isolates, we conducted a retrospective study during 2006-2008. Of 165 patients for whom bacterial cultures of blood, cerebrospinal fluid, or both were positive for S. suis serotype 2, the major multilocus sequence types (STs) found were ST1 (62.4%) and ST104 (25.5%); the latter is unique to Thailand. Clinical features were examined for 158 patients. Infections were sporadic; case-fatality rate for adults was 9.5%, primarily in northern Thailand. Disease incidence peaked during the rainy season. Disease was classified as meningitis (58.9%) or nonmeningitis (41.1%, and included sepsis [35.4%] and others [5.7%]). Although ST1 strains were significantly associated with the meningitis category (p<0.0001), ST104 strains were significantly associated with the nonmeningitis category (p<0.0001). The ST1 and ST104 strains are capable of causing sepsis, but only the ST1 strains commonly cause meningitis.
Low Rate Uniform Scalar Quantization of Memoryless Gaussian Sources (2006)

The low-rate (<;1 bits per sample) operational rate-distortion performance of uniform scalar quantizers for the memoryless Gaussian source is studied. Approximate analytical expressions for the operational rate-distortion function are derived, and the accuracy of the derived function is verified through simulation. It is shown that in the zero-rate limit the derived operational rate-distortion function is first-order optimal with respect to the Shannon lower bound. The derived function is used to study the performance of uniform scalar quantizers for the Gaussian Wyner-Ziv problem. Lastly, the derived low-rate rate-distortion function is used to provide improved low-rate bit allocation for jointly Gaussian vectors.
A Coil Positioning Method Integrated With an Orthogonal Decoupled Transformer for Inductive Power Transfer Systems (2022)

Misalignment between primary and secondary coils in inductive power transfer systems decreases power capacity and efficiency. In this article, a secondary coil positioning method integrated with an orthogonal decoupled transformer is proposed. This nested rectangular and solenoidal structure consists of a pair of double-D coils and a pair of solenoidal coils. The coils are integrated spatially and decoupled magnetically. Based on their directional selectivity characteristics, a coil positioning method is proposed prior to the power path activation. Coordinates can be obtained with polynomial fit calculations. The positioning method is compatible with power transfer and has merits of less auxiliary equipment, higher compatibility, and higher positioning precision considering both horizontal and vertical misalignment cases. The transformer performance is simulated with a three-dimensional finite element modeling tool and verified experimentally on a 3.2-kW prototype. In the preactivation sensing process, points distributed throughout a ±180 mm × 180 mm positioning range were tested. Experimental results show that 92% of tested points are accurate to within 10 mm given a 210 mm vertical distance. When air gap variations are taken into consideration, 90% of tested points are accurate to within 12 mm over the tested range. In the power transfer stage, the maximum full-power dc–dc system efficiency is 94.6%.
Single-mode guiding properties of subwavelength-diameter silica and silicon wire waveguides (2004)

Single-mode optical wave guiding properties of silica and silicon subwavelength-diameter wires are studied with exact solutions of Maxwell's equations. Single mode conditions, modal fields, power distribution, group velocities and waveguide dispersions are studied. It shows that air-clad subwavelength-diameter wires have interesting properties such as tight-confinement ability, enhanced evanescent fields and large waveguide dispersions that are very promising for developing future microphotonic devices with subwavelength-width structures.