gebhart/patrepeval huggingface dataset:
Tissue bound water studies on breast tumors using diffuse optical spectroscopy (2007)

Differences in tissue water state have been measured in normal and malignant breast tissues. Broadband Diffuse Optical Spectroscopy (DOS) has been used to acquire 650-1000 nm absorption spectra of normal and tumor breast tissues from 7 patients <i>in vivo</i>. The absolute values of spectral differences between normalized tissue water spectra and pure water spectra were combined and divided by the number of points in the sum to form the bound water index (BWI). In all subjects, the average BWIs of line scan points were significantly lower in tumor tissues (1.62 ± 0.27 x10<sup>-3</sup>) than normal tissues (3.06 ±0.51 x10<sup>-3</sup>, Wilcoxon Ranked Sum Test z= 0.003 and power=0.98). These results imply that the water in tumors behaves more like free water than the water in normal tissue.
The Small GTPase Arf6 Is Essential for the Tram/Trif Pathway in TLR4 Signaling (2013)

Recognition of lipopolysaccharides (LPS) by Toll-like receptor 4 (TLR4) at the plasma membrane triggers NF-κB activation through recruitment of the adaptor proteins Mal and MyD88. Endocytosis of the activated TLR4 allows recruitment of the adaptors Tram and Trif, leading to activation of the transcription factor IRF3 and interferon production. The small GTPase ADP-ribosylation factor 6 (Arf6) was shown to regulate the plasma membrane association of Mal. Here we demonstrate that inhibition of Arf6 also markedly reduced LPS-induced cytokine production in Mal(-/-) mouse macrophages. In this article, we focus on a novel role for Arf6 in the MyD88-independent TLR4 pathway. MyD88-independent IRF3 activation and IRF3-dependent gene transcription were strictly dependent on Arf6. Arf6 was involved in transport of Tram to the endocytic recycling compartment and internalization of LPS, possibly explaining its requirement for LPS-induced IRF3 activation. Together, these results show a critical role for Arf6 in regulating Tram/Trif-dependent TLR4 signaling.
Fast Proteolytic Digestion Coupled with Organelle Enrichment for Proteomic Analysis of Rat Liver (2004)

The use of an acid-labile surfactant as an alternative to urea denaturation allows for same-day proteolytic digestion and fast cleanup of cellular lysate samples. Homogenized rat liver tissue was separated into four fractions enriched in nuclei, mitochondria, microsomes (remaining organelles), and cytosol. Each subcellular fraction was then subjected to proteolytic digestion with trypsin for 2 h after denaturing with an acid-labile surfactant (ALS), separated by nanoflow reversed phase HPLC, and mass analyzed by tandem mass spectrometry in a 3-D ion trap. The results obtained from ALS denaturation for both organelle enrichment and whole cell lysate samples were comparable to those obtained from aliquots of the same samples treated by reduction, alkylation, and urea denaturation. Each method resulted in a similar number of peptides (694 for urea, 674 for ALS) and proteins (225 for urea, 229 for ALS) identified, with generally the same proteins (47% overlap) identified. As expected, organelle enrichment enabled the identification of more proteins (66% more with urea, 60% more with ALS) compared to a whole cell lysate. With organelle enrichment, the number of proteins with equal or increased sequence coverage went up by 73% with urea and 67% with ALS compared to the whole cell lysate. Additional information regarding the subcellular location of many proteins is obtained by organelle enrichment. While organelle enrichment is demonstrated with a bottom-up proteomics approach, it should be easily amenable to top-down proteomics approaches.
HEVC-Compatible Extensions for Advanced Coding of 3D and Multiview Video (2015)

This article provides an overview of standardized extensions of HEVC for the advanced coding of 3D and multiview video. In those extensions, new coding tools that better exploit the inter-view redundancy of the multiview texture videos have been developed. Additionally, dedicated tools for the improved coding of depth have been extensively studied and incorporated into the standard. In this paper, the performance of these extensions is assessed, and experimental results demonstrate notable gains in coding efficiency.
Melanoma NOS1 expression promotes dysfunctional IFN signaling (2014)

In multiple forms of cancer, constitutive activation of type I IFN signaling is a critical consequence of immune surveillance against cancer; however, PBMCs isolated from cancer patients exhibit depressed STAT1 phosphorylation in response to IFN-α, suggesting IFN signaling dysfunction. Here, we demonstrated in a coculture system that melanoma cells differentially impairs the IFN-α response in PBMCs and that the inhibitory potential of a particular melanoma cell correlates with NOS1 expression. Comparison of gene transcription and array comparative genomic hybridization (aCGH) between melanoma cells from different patients indicated that suppression of IFN-α signaling correlates with an amplification of the NOS1 locus within segment 12q22-24. Evaluation of NOS1 levels in melanomas and IFN responsiveness of purified PBMCs from patients indicated a negative correlation between NOS1 expression in melanomas and the responsiveness of PBMCs to IFN-α. Furthermore, in an explorative study, NOS1 expression in melanoma metastases was negatively associated with patient response to adoptive T cell therapy. This study provides a link between cancer cell phenotype and IFN signal dysfunction in circulating immune cells.
La recherche en marche (2007)

info:eu-repo/semantics/published
Bit patterned media based on block copolymer directed assembly with narrow magnetic switching field distribution (2010)

Electron-beam (E-beam) directed assembly, which combines the long-range phase and placement registration of e-beam lithography with the sharp dot size and spacing uniformity of block copolymer self assembly, is considered highly promising for fabricating templates that meet the tight magnetic specifications required for write synchronization in bit patterned media magnetic recording systems. In our study, we show that this approach also yields a narrower magnetic switching field distribution (SFD) than e-beam patterning or block copolymer self-assembly alone. We demonstrate that the pattern uniformity, i.e., island diameter and placement distributions are also important for achieving tight magnetic SFDs.
Editorial (2004)

With this first issue of Volume 10 of Natural Language Engineering we would like to take this opportunity to reflect on the development of the journal, especially over the last year or two, and to look forward to a number of future developments.
Implementation of organizational and pedagogical conditions for the development of social responsibility in the educational process of cadets (2021)

This article presents the results of the implementation of organizational and pedagogical conditions for the development of social responsibility of future officers of the National Guard of the Russian Federation. The author, in the course of conducting training sessions in various disciplines, creates organizational and pedagogical conditions that promote the development of social responsibility of the cadet's personality, modifying the traditional format of conducting classes: the technology of inverted class is introduced in the lecture classes; the technology of storytelling and the case study method are used in practical classes. In the seminar classes, the order of assessment of students is changed from individual to collective (inverted assessment). The pedagogical experiment has shown its effectiveness, which is confirmed by the analytical data presented in the content of the article. The organizational and pedagogical conditions tested during the educational process (the development of social responsibility as an important component of the professional training of future officers, the organization of a system of joint activities of the subjects of the educational process, the change in the system of evaluating the activities of cadets in the context of changes in the information presentation of material and the inclusion of various pedagogical technologies) can be recommended in pedagogical practice.
Automated Deep Learning-Based System to Identify Endothelial Cells Derived from Induced Pluripotent Stem Cells (2018)

Deep learning technology is rapidly advancing and is now used to solve complex problems. Here, we used deep learning in convolutional neural networks to establish an automated method to identify endothelial cells derived from induced pluripotent stem cells (iPSCs), without the need for immunostaining or lineage tracing. Networks were trained to predict whether phase-contrast images contain endothelial cells based on morphology only. Predictions were validated by comparison to immunofluorescence staining for CD31, a marker of endothelial cells. Method parameters were then automatically and iteratively optimized to increase prediction accuracy. We found that prediction accuracy was correlated with network depth and pixel size of images to be analyzed. Finally, K-fold cross-validation confirmed that optimized convolutional neural networks can identify endothelial cells with high performance, based only on morphology.
Functionalized main-group organometallics for organic synthesis (2002)

Abstract Highly functionalized Grignard-reagents can be easily obtained by an iodine­magnesim exchange reaction and further reacted with various electrophiles. Via a B­Zn exchange reaction, a formal Michael addition with umpolung of the reactivity can be achieved. Chiral phosphine ligands can be easily synthesized by a 2.3 sigmatropic rearrangement and used successfully in asymmetric synthesis.
Millimeter-Wave Downlink Coverage Extension Strategies (2020)

Traditionally, the uplink and downlink in a cellular network are associated with the same base station and the same frequency band since it promotes simpler network design, maintenance, and operation because of reduced complexity. However, when deploying millimeter-wave (mmWave) spectrum, network coverage has limitations hinging on the nature of the mmWave propagation characteristics relative to the traditional sub 6 GHz frequency bands. In this article, we present a method for an extension of the mmWave downlink coverage by demonstrating the benefits of decoupling the reverse and forward link frequencies and by leveraging macro-type radio deployment heights to maximize the line-of-sight coverage. The accompanying link budget analysis and coverage simulations quantify the benefit of the coverage extension methodology to be as much as 6.8 dB while extending possible coverage range distance to greater than 2 km.
Personalized Landmark Recommendation Based on Geotags from Photo Sharing Sites (2021)

Geotagged photos of users on social media sites provide abundant location-based data, which can be exploited for various location-based services, such as travel recommendation. In this paper, we propose a novel approach to a new application, i.e., personalized landmark recommendation based on users’ geotagged photos. We formulate the landmark recommendation task as a collaborative filtering problem, for which we propose a category-regularized matrix factorization approach that integrates both user-landmark preference and category-based landmark similarity. We collected geotagged photos from Flickr and landmark categories from Wikipedia for our experiments. Our experimental results demonstrate that the proposed approach outperforms popularity-based landmark recommendation and a basic matrix factorization approach in recommending personalized landmarks that are less visited by the population as a whole.
Vacuum‐assisted resin transfer molding using tackified fiber preforms (2001)

Abstract A low cost composite fabrication process—tackified SCRIMP—is described for fabricating aerospace‐grade composites based on tackification and vacuum‐assisted resin transfer molding (VARTM). Tackification based on a commercial tackifier (FT 500 from 3M) was used to make the net‐shape fiber preform. It was found that tackifier concentration and application conditions play important roles in governing the moldability of tackified fiber preforms. An epoxy resin (PR 500 from 3M) was used in the VARTM process‐SCRIMP at high temperatures. Experimental results show that composites with high fiber content (&gt; 60% by volume) can be manufactured at low cost using tackification. Effects of tackification methods on composite dimension control, void content and mechanical properties were investigated and compared in both RTM and SCRIMP.
Multimorbidity in patients with heart failure from 11 Asian regions: A prospective cohort study using the ASIAN-HF registry (2018)

ClinicalTrials.gov NCT01633398.
mflowgen (2022)

Achieving high code reuse in physical design flows is challenging but increasingly necessary to build complex systems. Unfortunately, existing approaches based on parameterized Tcl generators support very limited reuse as designers customize flows for specific designs and technologies, preventing their reuse in future flows. We present a vision and framework based on modular flow generators that encapsulates coarse-grained and fine-grained reusable code in modular nodes and assembles them into complete flows. The key feature is a flow consistency and instrumentation layer embedded in Python, which supports mechanisms for rapid and early feedback on inconsistent composition. We evaluate the design flows of successive generations of silicon prototypes built in TSMC16, TSMC28, TSMC40, SKY130, and IBM180 technologies, showing how our approach can enable significant code reuse in future flows.
In situ modification of semicarbazide surface of Love wave acoustic sensors for antibodies recognition (2008)

International audience
Cationic Functionalization of Chlorin Derivatives for Antimicrobial Photodynamic Inactivation and Related Vancomycin Conjugate (2018)

It is known that multiple cationic charges are required to produce broad-spectrum antimicrobial photosensitizers (PS) for photodynamic inactivation (aPDI) of bacteria and fungi. In the present study we describe the synthesis and aPDI testing of a set of derivatives prepared from the parent pheophytin molecule with different numbers of attached sidearms (1&#8210;3) each
Cytokine regulation of colony-stimulating factor (CSF) production in cultured human synovial fibroblasts. II. Similarities and differences in the control of interleukin-1 induction of granulocyte-macrophage CSF and granulocyte-CSF production (1992)

Synovial fibroblasts are likely to be a significant source of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte-CSF (G-CSF), which could be crucial to the pathogenesis of rheumatoid arthritis. Using specific enzyme-linked immunosorbent assays (ELISAs) and Northern analysis, GM-CSF and G-CSF expression were followed in human synovial fibroblast-like cells in response to a number of agents, either alone or in the presence of an optimal stimulatory concentration of interleukin-1 (IL-1). For both CSFs, interferon-gamma (100 U/mL) did not increase their levels but dramatically suppressed the stimulatory action of IL-1, while basic fibroblast growth factor (10(-8) mol/L), although nonstimulatory by itself, potentiated IL-1 action. The glucocorticoid, dexamethasone (10(- 7) mol/L), inhibited IL-1-stimulated CSF production. However, evidence was obtained for noncoordinated CSF regulation. Cyclooxygenase inhibitors potentiated the action of IL-1 on GM-CSF synthesis but suppressed G-CSF synthesis, suggesting that endogenous cyclooxygenase products can have opposite effects in modulating the levels of each CSF. Also, the lymphokine, IL-4 (250 pmol/L), slightly inhibited GM-CSF formation in the presence of IL-1 but elevated the G-CSF levels in these cultures without having an effect by itself. Transforming growth factor beta (less than or equal to 20 ng/mL) did not modulate levels of either CSF. Mesenchymal cell production of both GM-CSF and G-CSF is generally viewed as being under coordinate control; our findings suggest that their synthesis in IL-1-stimulated human synoviocytes can be modulated by a number of agents, in some cases with divergent actions depending on which CSF is examined.
Evaluation Metrics for the Paragon XP/S-15 (1993)

On February 17th 1993, the Numerical Aerodynamic Simulation (NAS) facility located at the NASA Ames Research Center installed a 224 node Intel Paragon XP/S-15 system. After its installation, the Paragon was found to be in a very immature state and was unable to support a NAS users' workload, composed of a wide range of development and production activities. As a first step towards addressing this problem, we implemented a set of metrics to objectively monitor the system as operating system and hardware upgrades were installed. The metrics were designed to measure four aspects of the system that we consider essential to support our workload: availability, utilization, functionality, and performance. This report presents the metrics collected from February 1993 to August 1993. Since its installation, the Paragon availability has improved from a low of 15% uptime to a high of 80%, while its utilization has remained low. Functionality and performance have improved from merely running one of the NAS Parallel Benchmarks to running all of them faster (between 1 and 2 times) than on the iPSC/860. In spite of the progress accomplished, fundamental limitations of the Paragon operating system are restricting the Paragon from supporting the NAS workload. The maximum operating system message passing (NORMA IPC) bandwidth was measured at 11 Mbytes/s, well below the peak hardware bandwidth (175 Mbytes/s), limiting overall virtual memory and Unix services (i.e. Disk and HiPPI I/O) performance. The high NX application message passing latency (184 microns), three times than on the iPSC/860, was found to significantly degrade performance of applications relying on small message sizes. The amount of memory available for an application was found to be approximately 10 Mbytes per node, indicating that the OS is taking more space than anticipated (6 Mbytes per node).
Atomic layer deposition of tin oxide films using tetrakis(dimethylamino) tin (2008)

The authors present a new method for preparing thin films of SnO2 by atomic layer deposition (ALD) using alternating exposures to tetrakis(dimethylamino) tin and hydrogen peroxide. This method avoids problems of corrosion and agglomeration associated with the halogenated compound, SnCl4. Tin oxide films were successfully deposited on a variety of substrates using deposition temperatures of 50–300°C at an average growth rate of 1.2Å∕cycle. They use in situ quartz crystal microbalance and quadrupole mass spectrometry measurements to explore the mechanism for SnO2 ALD. Scanning electron microscopy of SnO2 films deposited on Si(100) show that the SnO2 films are smooth, conformal, and nearly featureless, while atomic force microscopy yields a surface roughness of only 0.84nm for a film with a thickness of 92nm. X-ray diffraction reveals that the SnO2 films are amorphous. Films deposited on glass yielded a resistivity of ∼0.3Ωcm and an optical transmission of 94% for a film thickness of 140nm. X-ray photoelectron spectroscopy measurements were consistent with residual dimethylamine ligands remaining in the film at deposition temperatures below 150°C. This method allows, for the first time, low temperature (50°C) growth of SnO2 films by ALD. Additionally, they show that this process is suitable for conformally coating high aspect ratio anodic alumina membranes.
OBSERVATION OF VIBRATIONALLY INDUCED DIPOLE MOMENTS IN TETRAHEDRAL MOLECULES (1971)

Present address of Annabel A. Muenter: Eastman Kodak Company, Rochester, New York 14650.""
Whitening and second order optimization both make information in the\n dataset unusable during training, and can reduce or prevent generalization (2020)

Machine learning is predicated on the concept of generalization: a model\nachieving low error on a sufficiently large training set should also perform\nwell on novel samples from the same distribution. We show that both data\nwhitening and second order optimization can harm or entirely prevent\ngeneralization. In general, model training harnesses information contained in\nthe sample-sample second moment matrix of a dataset. For a general class of\nmodels, namely models with a fully connected first layer, we prove that the\ninformation contained in this matrix is the only information which can be used\nto generalize. Models trained using whitened data, or with certain second order\noptimization schemes, have less access to this information, resulting in\nreduced or nonexistent generalization ability. We experimentally verify these\npredictions for several architectures, and further demonstrate that\ngeneralization continues to be harmed even when theoretical requirements are\nrelaxed. However, we also show experimentally that regularized second order\noptimization can provide a practical tradeoff, where training is accelerated\nbut less information is lost, and generalization can in some circumstances even\nimprove.\n
Long‐Duration Transmission of Information with Infofuses (2010)

“Infofuse” for long: “Infofuses”—chemically based systems for non-electronic communication that can transmit alphanumeric information encoded as pulses of light (see picture)—can now operate for hours without extinction. These characteristics improve their potential for a new approach to information technology that combines chemistry and information—“infochemistry”.
An artificial neural network for optimizing safety and quality in thermal food processing (1999)

Presents a backpropagation artificial neural network for optimizing food safety and quality in thermal processing applications. Five inputs (can size, initial temperature, thermal diffusivity, sensitivity indicator of microorganism, and sensitivity indicator of quality) are used as inputs to the network. The network computes the optimal control parameters (sterilization temperature, process time) and quality degradation of the food. This study is based on a wide range of microorganisms involved in foods.
Demonstration of the Prototype of the Network Camera with Sender Initiated Congestion Control (2007)

We demonstrate the prototype of the network camera with a multicast transport-layer protocol called Sender Initiated Congestion Control (SICC) which provides adaptive flow control for multicast methods such as Application Layer Multicast (ALM) or eXplicit multi-unicast6 (XCAST6). SICC is capable of achieving fast congestion avoidance and significantly increases throughput at receivers while still remaining TCP friendly. We verified the applicability to small appliance by implementing SICC/XCAST6 on a prototype network camera We demonstrate the prototype of network camera and receiver terminals with viewer. It shows the capability of adaptive flow control to multiple receivers with or without competing traffics.