gebhart/patrepeval huggingface dataset:
PE-071: The Possibility of Radiotherapy for Downstaging before Living Donor Liver Transplantation for Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis (2016)

Aims: Advanced HCC with portal vein tumor thrombus (PVTT) patients are excluded for liver transplantation (LT), according to the Milan criteria. But after the development of conformal RT, there have been several trials on RT as a bridge or downstaging management approach to LT. The purpose of our study is to evaluate the value of living donor liver transplantation (LDLT) following RT in PVTT patients. Methods: This study took place between May 1996 and March 2013; a, total of 1360 patients were treated by LT in our institution, and 5 of those recipients had RT due to PVTT. To confirm the value of LDLT following RT in PVTT, we did a propensity-matched study retrospectively. Results: There were no statistically significant differences in the clinical characteristics of the two groups. All LT was done by LDLT with duct to duct anastomosis and the mean operation time was 588 minutes. During the follow-up periods, in the LDLT following RT group, two recipients exhibited disease progression, but in the RT alone group, all patients had tumor ingrowths or either intra- or extra- hepatic metastasis. The OS for the LDLT following RT group was 1055 days and that of the RT alone group was 367 days, and there was a statistically significant difference. Conclusions: LDLT following RT can be the treatment of choice for PVTT in select patients and when bile duct anastomosis was performed in RT recipients, a hepaticojejunostomy was recommended to prevent biliary complications.
Dual‐analgesic loadedUHMWPEexhibits synergistic antibacterial effects againstStaphylococci (2022)

Total joint arthroplasty is one of the most common surgeries in the United States, with almost a million procedures performed annually. Periprosthetic joint infections (PJI) remain the most devastating complications associated with total joint replacement. Effective antibacterial prophylaxis after primary arthroplasty could substantially reduce incidence rate of PJI. In the present study we propose to provide post-arthroplasty prophylaxis via dual-analgesic loaded ultra-high molecular weight polyethylene (UHMWPE). Our approach is based on previous studies that showed pronounced antibacterial activity of analgesic- and NSAID-loaded UHMWPE against Staphylococci. Here, we prepared bupivacaine/tolfenamic acid-loaded UHMWPE and assessed its antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis. Dual-drug loaded UHMWPE yielded an additional 1-2 log reduction of bacteria, when compared with single-drug loaded UHMWPE. Analysis of the drug elution kinetics suggested that the observed increase in antibacterial activity is due to the increased tolfenamic acid elution from dual-drug loaded UHMWPE. We showed that the increased fractal dimension of the drug domains in UHMWPE could be associated with increased drug elution, leading to higher antibacterial activity. Dual-analgesic loaded UHMWPE proposed here can be used as part of multi-modal antibacterial prophylaxis and promises substantial reduction in post-arthroplasty mortality and morbidity.
Demonstration of the Control of Rabbit Skeletal-Muscle Phosphorylase Kinase Activity in vivo by Adenosine 3′5′-Cyclic Monophosphate-Dependent Protein Kinase (1974)

Conference Article| October 01 1974 Demonstration of the Control of Rabbit Skeletal-Muscle Phosphorylase Kinase Activity in vivo by Adenosine 3′5′-Cyclic Monophosphate-Dependent Protein Kinase STEPHEN J. YEAMAN; STEPHEN J. YEAMAN 1Department of Biochemistry, Medical Sciences Institute, The University, Dundee DD1 4HN, U.K. Search for other works by this author on: This Site PubMed Google Scholar PHILIP COHEN PHILIP COHEN 1Department of Biochemistry, Medical Sciences Institute, The University, Dundee DD1 4HN, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1974) 2 (5): 931–932. https://doi.org/10.1042/bst0020931 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation STEPHEN J. YEAMAN, PHILIP COHEN; Demonstration of the Control of Rabbit Skeletal-Muscle Phosphorylase Kinase Activity in vivo by Adenosine 3′5′-Cyclic Monophosphate-Dependent Protein Kinase. Biochem Soc Trans 1 October 1974; 2 (5): 931–932. doi: https://doi.org/10.1042/bst0020931 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1974 Biochemical Society1974 Article PDF first page preview Close Modal You do not currently have access to this content.
Supplementary Figures 1-5 from Mice Lacking <i>bi-1</i> Gene Show Accelerated Liver Regeneration (2023)

Supplementary Figures 1-5 from Mice Lacking &lt;i&gt;bi-1&lt;/i&gt; Gene Show Accelerated Liver Regeneration
Fluorogenic affinity label for the facile, rapid imaging of proteins in live cells (2009)

Haloalkane dehalogenase (HD) catalyzes the hydrolysis of haloalkanes via a covalent enzyme-substrate intermediate. Fusing a target protein to an HD variant that cannot hydrolyze the intermediate enables labeling of the target protein with a haloalkane in cellulo. The utility of extant probes is hampered, however, by background fluorescence as well as limited membrane permeability. Here, we report on the synthesis and use of a fluorogenic affinity label that, after unmasking by an intracellular esterase, labels an HD variant in cellulo. Labeling is rapid and specific, as expected from the reliance upon enzymic catalysts and the high membrane permeance of the probe both before and after unmasking. Most notably, even high concentrations of the fluorogenic affinity label cause minimal background fluorescence without a need to wash the cells. We envision that such fluorogenic affinity labels, which enlist catalysis by two cellular enzymes, will find utility in pulse-chase experiments, high-content screening, and numerous other protocols.
Depolarization in the Mueller calculus (2003)

Depolarization is the generation of partially polarized light or unpolarized light from a completely polarized incident beam. For example when polarized light scatters from rough surfaces, the degree of polarization is usually reduced from one. Depolarization figures of merit are discussed and difficulties with the depolarization index are highlighted. Interesting depolarization patterns are presented for a liquid crystal in reflection are measured with a commercial polarimeter. Depolarization data from rough metal surfaces and paint is also discussed.
Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment (2014)

Synaptotagmin (syt) 7 is one of three syt isoforms found in all metazoans; it is ubiquitously expressed, yet its function in neurons remains obscure. Here, we resolved Ca(2+)-dependent and Ca(2+)-independent synaptic vesicle (SV) replenishment pathways, and found that syt 7 plays a selective and critical role in the Ca(2+)-dependent pathway. Mutations that disrupt Ca(2+)-binding to syt 7 abolish this function, suggesting that syt 7 functions as a Ca(2+)-sensor for replenishment. The Ca(2+)-binding protein calmodulin (CaM) has also been implicated in SV replenishment, and we found that loss of syt 7 was phenocopied by a CaM antagonist. Moreover, we discovered that syt 7 binds to CaM in a highly specific and Ca(2+)-dependent manner; this interaction requires intact Ca(2+)-binding sites within syt 7. Together, these data indicate that a complex of two conserved Ca(2+)-binding proteins, syt 7 and CaM, serve as a key regulator of SV replenishment in presynaptic nerve terminals. DOI: http://dx.doi.org/10.7554/eLife.01524.001.
Inside Jokes (2015)

Humor is an integral aspect of the human experience. Motivated by the prospect of creating computational models of humor, we study the influence of the language of cartoon captions on the perceived humorousness of the cartoons. Our studies are based on a large corpus of crowdsourced cartoon captions that were submitted to a contest hosted by the New Yorker. Having access to thousands of captions submitted for the same image allows us to analyze the breadth of responses of people to the same visual stimulus.
Effect of Chronic and Acute Thyroid Hormone Reduction on Perioperative Outcome (1998)

Department of Anesthesiology, Mount Sinai Medical Center, New York, New York; Departments of Anesthesiology, Surgery and Pharmacology, Duke Heart Center, Duke University Medical Center, Durham, North Carolina
Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction (2016)

Endogenous phosphodiesterase 2 contributes to heart rate regulation. Greater phosphodiesterase 2 abundance protects against arrhythmias and improves contraction force after severe ischemic insult. Activating myocardial phosphodiesterase 2 may, thus, represent a novel intracellular antiadrenergic therapeutic strategy protecting the heart from arrhythmia and contractile dysfunction.
Supplementary Table 1 from Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism Arrays (2023)

Supplementary Table 1 from Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism Arrays
Advanced Hybrid Metal/Polymer Nanostructures for Nanophotonics (2014)

International audience
Spin relaxation and intervalley scattering in 2D semiconductors (Presentation Recording) (2015)

Monolayer transition metal dichalcogenides, MX2 (M = Mo, W and X = S, Se), are direct-gap semiconductors with some interesting properties. First, the low-dimensional hexagonal structure leads to two inequivalent K-points, K and K’, in the brillioun zone. Second, this valley index and spin are intrinsically coupled, and spin-dependent selection rules enable one to independently populate and interrogate a unique K valley with circularly polarized light. Here we probe the degree of circular polarization of the emitted photoluminescence as function of the photo-excitation energy and temperature to elucidate spin-dependent inter- and intra-valley relaxation mechanisms. Monolayer flakes of MoS2 and MoSe2 show a strong depolarization as the excitation energy is increased. However, WS2 maintains significant polarization for high excitation energies, even at room temperature when properly prepared. We discuss the behavior of the polarization in terms of various phonon assisted intervalley scattering processes. This work was supported by NRL and the NRL Nanoscience Institute
Drude Relaxation Rate in Grained Gold Nanoantennas (2010)

The effect of grain boundaries on the electron relaxation rate is significant even for large area noble metal films and more so for plasmonic nanostructures. Optical spectroscopy and X-ray diffraction show a substantial improvement in plasmon resonance quality for square-particle nanoantennas after annealing due to an enlarged grain size from 22 to 40 nm and improved grain boundaries described by the electron reflection coefficient. The electron relaxation rate due to the grains is shown to decrease by a factor of 3.2.
Photoreflectance study on residual strain in heteroepitaxial gallium arsenide on silicon (1990)

The effect of residual strain on photoreflectance (PR) signals near the heteroepitaxial interface in gallium arsenide (GaAs) grown directly on a silicon substrate has been systematically investigated. With use of data on the stress-induced splitting and the shift of the ${\mathit{E}}_{0}$ (${\ensuremath{\Gamma}}_{8v}$-${\ensuremath{\Gamma}}_{6c}$) fundamental transition, the distribution of residual strain in the vicinity of the heteroepitaxial interface in the GaAs layer has been evaluated. It has been found that compressive strain caused by the lattice mismatch between the materials is not completely compensated and is about 0.4% near the heterointerface in the GaAs layer grown at relatively low growth temperature. This compressive strain gradually relaxes with increasing thickness and then transforms to tensile strain around thicknesses greater than 2 \ensuremath{\mu}m. The residual tensile strain at the surface of a 3.6-\ensuremath{\mu}m-thick GaAs layer is about 0.2%. In the thickness range from 0.5 to 2 \ensuremath{\mu}m, the observed PR spectra demonstrate the presence of two regions with different strain in the epitaxial layer. For thicknesses less than 0.5 \ensuremath{\mu}m, crystal quality is degraded by defects associated with misfit compensation during the initial stage of growth.
Efficiency Analysis of a Wave Power Generation System by Using Multibody Dynamics (2016)

파력발전시스템의 에너지 흡수 효율은 입사파의 파력과 발전기 구동 동력의 비로 정의된다. 흡수효율은 파력발전시스템의 동적 거동에 의존하기 때문에 파력발전시스템의 에너지 흡수 효율을 예측하기 위해서 파력발전시스템의 동적 해석이 요구된다. 본 논문에서는 에너지 흡수 효율을 예측하기 위하여 파력발전시스템의 동적 해석을 수행하였다. 파력발전시스템의 동적 해석을 위해서 상용 다물체동역학 해석 프로그램인 RecurDyn을 사용하였고, 부유체에 작용하는 파력을 모델링하기 위해서 Morison equation을 적용하였다. 효율분석 결과 파고가 낮고, 주기가 짧을수록 흡수효율이 높아지는 경향을 보인다.
Cyclic Olefin Resist Polymers and Polymerizations for Improved Etch Resistance. (1999)

This paper will describe the strengths and unique challenges of building 193nm resists from acrylic polymers and cyclic olefin polymers. In particular, cyclic olefin (alternating) copolymer synthesis and properties will be discussed.
A novel bifunctional protein supramolecule for construction of carbon nanotube–titanium hybrid material (2011)

Carbon nanotube-TiO(2) hybrid materials with many nano-scale cavities were realized using a bifunctional protein supramolecule possessing carbonaceous material-binding peptides and Ti-binding peptides. The obtained structure was confirmed to consist of a central nanotube, surrounding proteins, and a swathing titanium-layer. All processes were carried out at room temperature, using an environmentally friendly method.
Hierarchically Self‐Assembled Star‐Shaped ZnO Microparticles for Electrochemical Sensing of Amines (2016)

Novel, hierarchically nanostructured, star-shaped ZnO (SSZ) microparticles are synthesized by a hydrothermal synthetic route. The SSZ microparticles serve as effective platforms for electrochemical detection of amines in solution. The morphology and structure of the materials are characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, and UV/Vis spectroscopy. The as-synthesized SSZ microparticles comprise self-assembled hexagonal prisms that possess nanometer and micrometer pores in their structure and on their surfaces-structural features that are conducive to sensing applications. An electrode fabricated by using the hierarchically nanostructured SSZ materials serve as a sensitive electrochemical sensor for detection of low concentrations of ethylenediamine, with a sensitivity of 2.98×10(-2) mA cm(-2) mm(-1) , a detection limit of 2.36×10(-2) mm, and a short response time of 8 s.
High performance package designs for a 1 GHz microprocessor (2001)

This paper describes the architecture and design of an organic land grid array (OLGA) and a flip chip pin grid array (FCPGA) package for a 32 b microprocessor with a clock frequency of 1 GHz and an I/O bus designed to run at 133 MHz. Cost and performance targets and compatibility with existing systems are the key accomplishments of this design project. Issues and implementation details of each of these aspects are discussed and contrasted here. This paper concentrates on the processor performance issues associated with the package routing and power delivery. To overcome high inductance associated with the socket and package pins in the FCPGA package, decoupling capacitors were placed on the underside of the package substrate. This paper discusses an optimal placement scheme for the capacitors and their effectiveness in performance improvement of the system compared to the OLGA package case.
High Electron Mobility in Air for N,N′‐1H,1H‐Perfluorobutyldicyanoperylene Carboxydi‐imide Solution‐Crystallized Thin‐Film Transistors on Hydrophobic Surfaces (2011)

High-mobility and air-stable n-type organic field transistors based on solution-crystallized N,N′-1H,1H-perfluoro­butyldicyanoperylene carboxydi-imide (PDIF- CN2) are developed. Electron mobility as high as 1.3 cm2 V−1 s−1 is achieved owing to the almost-perfect periodic crystal packing.
Thermal Diodes Based on Near-Field Radiation (2015)

We demonstrate near-field radiative heat transfer between nanostructures and show that it dominates over other on-chip conduction channels. The measured heat transfer behavior matches the predictions of boundary element method simulations for parallel nanobeams.
Fiber Nonlinearity Compensation by Digital Backpropagation of an Entire 1.2-Tb/s Superchannel Using a Full-Field Spectrally-Sliced Receiver (2013)

We receive the full optical field of a 176-GHz wide, 1.2-Tb/s PDM-16QAM superchannel after 960-km TWRS using a spectrally-sliced coherent receiver. Simultaneous compensation of SPM and XPM with digital backpropagation enables 1 dB of Q-factor improvement.
Synthesis Of N-Labeled Peptidyl AMP (2000)

This paper deals with the synthesis of a new type of N-labeled peptidyl AMP, which would be used as a good substrate for analysis of the peptidyl transfer reaction on ribosome and for co-crystallization with ribosome. 4-(Dimethylamino)azobenzene-4'-sulfonyl (Dabsyl) was selected as the labeling group. (N-Dabsylglycyl)-L-leucyl AMP was synthesized from glycyl-L-leucine via a three-step procedure.
Retardiert freigesetztes Phosphatidylcholin bessert den Verlauf der chronisch aktiven Colitis ulcerosa (2004)

Hypothese: Durch topische Applikation von Phosphatidylcholin im Colon kann die entzündliche Aktivität bei Colitis ulcerosa vermindert werden.
Multimodal segmentation of object manipulation sequences with product models (2011)

In this paper we propose an approach for unsupervised segmentation of continuous object manipulation sequences into semantically differing subsequences. The proposed method estimates segment borders based on an integrated consideration of three modalities (tactile feedback, hand posture, audio) yielding robust and accurate results in a single pass. To this end, a Bayesian approach originally applied by Fearnhead to segment one-dimensional time series data -- is extended to allow an integrated segmentation of multi-modal sequences. We propose a joint product model which combines modality-specific likelihoods to model segments. Weight parameters control the influence of each modality within the joint model. We discuss the relevance of all modalities based on an evaluation of the temporal and structural correctness of segmentation results obtained from various weight combinations.
Reliefs as images (2010)

We describe how to create relief surfaces whose diffuse reflection approximates given images under known directional illumination. This allows using any surface with a significant diffuse reflection component as an image display. We propose a discrete model for the area in the relief surface that corresponds to a pixel in the desired image. This model introduces the necessary degrees of freedom to overcome theoretical limitations in shape from shading and practical requirements such as stability of the image under changes in viewing condition and limited overall variation in depth. The discrete surface is determined using an iterative least squares optimization. We show several resulting relief surfaces conveying one image for varying lighting directions as well as two images for two specific lighting directions.
Disease course heterogeneity and OCT in multiple sclerosis (2014)

The thicknesses, particularly of the innermost retinal layers (RNFL, GCC), were significantly related to the heterogeneous disease course in MS. The relative preservation of these layers in primary progressive and benign MS suggests rather limited susceptibility of the retina to neurodegeneration, which may be relevant for future neurodegenerative treatment trials employing OCT as a secondary outcome measure in primary progressive MS.
Thermoelectric and bulk mobility measurements in pentacene thin films (2011)

Low-noise thermoelectric and electrical measurements were used to derive the dependences of Seebeck coefficient and hole mobility on carrier concentration and grain size in the “bulk” regions of thermally evaporated pentacene thin films (in contrast to the channel field-effect mobility typically measured using thin-film transistor geometries). Distinct charge transport regimes were observed for larger (0.5 and 0.8 μm) and smaller (0.2 μm) grain sizes, attributed to carrier-dopant scattering and percolation, respectively.
Acceleration of lithotripsy using cavitation bubbles induced by second-harmonic superimposition (2016)

Abstract Shock wave lithotripsy potentially produces residual stone fragments too large to pass through ureters and significant injury to the normal tissue surrounding the stone. Previous works have shown that the collapse of cavitation bubbles induced by high-intensity focused ultrasound can produce small stone fragments via cavitation erosion. However, the erosion rate is hypothesized to be reduced by ultrasound attenuation by excessively generated bubble clouds. If so, it is important to generate the bubbles only on the stone surface. The effects of peak-negative-enhanced (PNE) and peak-positive-enhanced (PPE) waves obtained by second-harmonic superimposition were investigated to control cavitation bubbles. With the PNE waves, the bubbles were generated only on the stone surface and the maximum erosion rate was 232 ± 32 mg/min. All the fragments were smaller than 2 mm, which makes them pass through ureters naturally. The proposed method shows the potential to significantly improve the speed of lithotripsy.
Supplementary Table S5B from Cancers as Wounds that Do Not Heal: Differences and Similarities between Renal Regeneration/Repair and Renal Cell Carcinoma (2023)

Supplementary Table S5B from Cancers as Wounds that Do Not Heal: Differences and Similarities between Renal Regeneration/Repair and Renal Cell Carcinoma
Mitigation of Fiber Nonlinearity Using a Digital Coherent Receiver (2010)

Coherent detection with receiver-based DSP has recently enabled the mitigation of fiber nonlinear effects. We investigate the performance benefits available from the backpropagation algorithm for polarization division multiplexed quadrature amplitude phase-shift keying (PDM-QPSK) and 16-state quadrature amplitude modulation (PDM-QAM16). The performance of the receiver using a digital backpropagation algorithm with varying nonlinear step size is characterized to determine an upper bound on the suppression of intrachannel nonlinearities in a single-channel system. The results show that for the system under investigation PDM-QPSK and PDM-QAM16 have maximum step sizes for optimal performance of 160 and 80 km, respectively. Whilst the optimal launch power is increased by 2 and 2.5 dB for PDM-QPSK and PDM-QAM16, respectively, the Q-factor is correspondingly increased by 1.6 and 1 dB, highlighting the importance of studying nonlinear compensation for higher level modulation formats.