gebhart/patrepeval huggingface dataset:
Surface Reactions of μ2-η2-(tBu-acetylene)dicobalthexacarbonyl with Oxidized and H-terminated Si(111) Surfaces (2011)

The reactions of a gas-phase metal carbonyl μ2-η2-(tBu-acetylene)dicobalthexacarbonyl (CCTBA) with oxidized (SiO2) and H-terminated (H/Si(111)) silicon surfaces at decarbonylation temperature (140 °C) are presented. Upon the first CCTBA exposure, the surface reactions strongly depend on the nature of the surfaces. On H/Si(111), metallic Si−Co bonds are formed after ∼80% of the Si−H bonds are consumed, and the carbonyl groups of the ligand form a stable structure of mixed Co2(CO)6 and semibridging CO. In contrast, Si−O−Co bonds are formed on SiO2 at the outset, as confirmed by both IR absorbance spectra and Co 2p core-level XPS. Furthermore, carbonyls are not observed on SiO2 after a completion of the first reaction, because of a weakening of their bond by the change of the Co oxidation state from Co0 in CCTBA to Co2+ in Si−O−Co. On both substrates, the surface reaction of CCTBA gives rise to hydrosilylation, converting the alkyne group of the ligand into a C═C bond at the surface, which is very likely catalyzed by the presence of the cobalt carbonyl CCTBA itself. A cyclic CCTBA exposure of 2 s at 140 °C, followed by a 300 °C anneal, leads to metallic Co deposition on both H/Si(111) and SiO2 surfaces, with Co thicknesses of 5 Å and 14 Å, respectively, after 15 cycles. After a few cycles, the surface chemistry changes, leading predominantly to the formation of enones together with (semi)bridging carbonyls.
Molecular and Subunit Heterogeneity of Legumin ofPisum sativumL. (Garden Pea)— A Multi-Dimensional Gel Electrophoretic Study (1981)

Pisum sativum legumin has been shown to be heterogeneous with respect to the existence of different molecular forms, the molecular weights of subunit pairs, and the molecular weights and isoelectric points of constituent subunits. Disulphide-bonded subunit pairs with mol. wt. 54 000 constitute a major part of total legumin. In addition, subunit pairs varying in mol. wt. from 35 000 to 58 000 have been observed which associate in various ways to give rise to at least three distinct molecular forms of legumin separable on non-dissociating gels. ‘Three-dimensional’ gel electro-phoresis has been employed to understand the consitution of these forms in detail.
Pericardial Reconstruction Using an Extracellular Matrix Implant Correlates with Reduced Risk of Postoperative Atrial Fibrillation in Coronary Artery Bypass Surgery Patients (2010)

In this retrospective study, pericardial reconstruction with the ECM implant contributed directly to a statistically significant and clinically meaningful reduction in the rate of postoperative AF in patients undergoing primary isolated CABG. A prospective multicenter randomized trial has been planned to further test this approach.
Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families (2005)

Bruton's tyrosine kinase (Btk) plays critical roles in B cell development and activation. Mutations of Btk cause X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency in mice. An Src homology domain 2-kinase linker region exists in all Src, Abl, ZAP70/Syk and Btk/Tec non-receptor tyrosine kinase families. Missense mutations in the Btk linker region can cause XLA, supporting an essential role for this protein segment. We investigated the regulatory role of the linker region in Btk function by mutational analysis. XLA-causing mutations L369F and R372G abolished Btk-mediated calcium response without affecting Btk protein stability and kinase activity significantly. Although mutation of a well-conserved tryptophan (W260A) in the linker region of the Src family kinase Hck has been shown to cause a hyperactive kinase, an analogous mutation in Btk (W395A) dramatically decreased Btk kinase activity. Tyrosine phosphorylation in the linker region was previously shown to regulate the function of Abl and ZAP70/Syk kinases. Even though tyrosine phosphorylation was detected on tyrosine 375 in the Btk linker region, no significant alteration was observed in Btk-signaling activity and biological function when this tyrosine was mutated in DT-40 cells or in Y375F knock-in mice. Our data and previous studies suggest that each cytoplasmic tyrosine kinase family has evolved a unique strategy to utilize the linker region to regulate the function of the enzyme.
[Practice guideline 'Perinatal management of extremely preterm delivery']. (2010)

At the request of the State Secretary of the Dutch Ministry of Health, Welfare and Sport a national multidisciplinary workgroup developed an evidence-based practice guideline for the management of pregnant women with an imminent preterm delivery after a pregnancy of less than 26 weeks duration and for extremely preterm neonates. Active care measures are advised for neonates from a gestational age of 24 0/7 weeks onwards, unless there are serious arguments that justify a conservative management. In cases of imminent preterm delivery, intrauterine transport to a perinatological care centre is advised from a gestational age of 23 4/7 weeks onwards. In cases of imminent preterm delivery, glucocorticoids to enhance fetal lung maturity should be administered from a gestational age of 23 5/7 weeks onwards. From a gestational age of 24 0/7 weeks onwards a caesarean section may be considered if the fetal condition during spontaneous labour justifies this.
A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens (2022)

The emergence of multidrug-resistant (MDR) Gram-negative pathogens is an urgent global medical challenge. The old polymyxin lipopeptide antibiotics (polymyxin B and colistin) are often the only therapeutic option due to resistance to all other classes of antibiotics and the lean antibiotic drug development pipeline. However, polymyxin B and colistin suffer from major issues in safety (dose-limiting nephrotoxicity, acute toxicity), pharmacokinetics (poor exposure in the lungs) and efficacy (negligible activity against pulmonary infections) that have severely limited their clinical utility. Here we employ chemical biology to systematically optimize multiple non-conserved positions in the polymyxin scaffold, and successfully disconnect the therapeutic efficacy from the toxicity to develop a new synthetic lipopeptide, structurally and pharmacologically distinct from polymyxin B and colistin. This resulted in the clinical candidate F365 (QPX9003) with superior safety and efficacy against lung infections caused by top-priority MDR pathogens Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae.
A three-phase bi-directional IPT system for contactless charging of electric vehicles (2011)

Contactless and bi-directional power transfer is preferable for applications such as electric vehicles (EVs) and vehicle-to-grid (V2G) systems. This paper presents a new three-phase and bi-directional IPT system that is suitable for rapid charging of EVs or high power V2G systems. The proposed system uses a three-phase track, which is coupled to a three-phase pick-up through weak magnetic coupling. Both track and pick-up are var compensated through an inductor-capacitor-inductor (LCL) resonant circuit and driven by reversible rectifiers. A mathematical model is presented to show that power transfer from the track (primary) side to the pick-up side in both directions can be controlled through either magnitude or relative phase angle of the voltages generated by reversible rectifiers. The viability of the proposed concept is demonstrated using simulations, and results suggest that the three-phase IPT system is suitable for high power applications and is superior in performance to its single-phase counterpart.
Photoisomerization of triquinacene congeners (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoisomerization of triquinacene congenersLeo A. Paquette, James D. Kramer, Paul B. Lavrik, and Matthew J. WyvrattCite this: J. Org. Chem. 1977, 42, 3, 503–506Publication Date (Print):February 1, 1977Publication History Published online1 May 2002Published inissue 1 February 1977https://doi.org/10.1021/jo00423a023RIGHTS & PERMISSIONSArticle Views81Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (582 KB) Get e-Alerts Get e-Alerts
Spectroscopic ellipsometry study of thin diffusion barriers of TaN and Ta for Cu interconnects in integrated circuits (2007)

The objective of this work is to study the optical and electrical properties of tantalum nitride and tantalum barrier thin films used against copper diffusion in Si in integrated circuits using spectroscopic ellipsometry in the VUV and UV–visible range. Single layers of tantalum nitride and bilayer films of Ta/TaN were produced by reactive magnetron sputtering on Si(100) substrates covered with a native oxide layer. Ellipsometric measurements were performed in the energy range from 0.73–8.7 eV and the dielectric functions were simulated using Drude–Lorentz model and effective medium approximation (EMA) in order to obtain information regarding film thickness, film composition, free carrier plasma energy, mean relaxation time and electrical resistivity. The film thickness clearly affects the electrical resistivity and the electron mean free path. It was observed that for films of Ta on TaN even after maintaining the deposition condition suitable for the β-phase of Ta, it turned out to be a mixture of αand β-phases with higher contribution of the α-phase. It is shown that even a very small intermixture of two different phases of Ta can be determined accurately using ellipsometry.
The Stereochemistry of Variabilin, an Antimicrobial Sesterterpene Isolated from Marine Sponges (1993)

Abstract Variabilin (1), an antimicrobial furanosesterterpene, has been isolated from an Okinawan marine sponge Amphidmedon sp. and its absolute stereochemistry at the C-18 position was determined as S by synthesis of a degradation product of 1.
Interferometric phase contrast imaging and tomography using incoherent radiation sources (2006)

We report how an interferometic method can produce quantitative x-ray and neutron phase contrast images. The interferometer is based on diffraction gratings fabricated using microlithography techniques. Separate phase and absorption images are recorded simultaneously [1]. By taking data sets under many viewing angles, a tomographic reconstruction of both the real part and the imaginary part of the objects complex refractive index distribution can be obtained. In the x-ray case, the method can be used to enhance the contrast in medical radiography and it has the potential to reduce the applied radiation dose. As opposed to existing techniques, the method requires only little coherence and can be scaled up to fields of view of many centimetres (see Fig. 1). Its application is therefore not limited to be used at synchrotron light sources, but it can be used with standard x-ray tube sources [2]. This opens up a wide range of applications in medical imaging and non destructive testing. In addition, very recent experiments with cold neutron radiation are presented [3]. Again phase contrast images and tomographic data sets were recorded. Our technique opens up the way for combining an imaging approach with information obtained through the quantum mechanical interactions of neutrons with matter.
Thyristor compact model for ESD, DC and RF simulation (2013)

A Spice Gummel-Poon based thyristor compact model is developed. It is integrating ESD, DC and RF circuit simulation capability in one model. The paper shows a simplified parameter extraction flow for a dynamically triggered thyristor. The model validity is demonstrated in product like sub-circuits and for a CMOS high-speed transmitter.
Local Impact of Pt Nanodeposits on Ionomer Decomposition in Polymer Electrolyte Membranes (2017)

Based on recent theoretical studies, we designed a multistep experimental protocol to understand the impact of environmental conditions around Pt nanodeposits on membrane chemical degradation. The first experiment probes the local potential at a Pt microelectrode for different rates of permeation of hydrogen and oxygen gases from anode and cathode side. The subsequent degradation experiment utilizes the local conditions taken from the first experiment to analyze local rates of ionomer degradation. The rate of ionomer decomposition is significantly enhanced in the anodic H2-rich membrane region, which can be explained with the markedly increased amount of H2O2 formation at Pt nanodeposits in this region.
AMC-Backed Flexible Near-Endfire Wearable Antennas for On-Body Communications (2016)

This chapter presents a multi-layered artificial magnetic conductor (AMC)-backed endfire planar Yagi antenna on a flexible latex substrate, such that the bidirectional-endfire radiation is altered to an off-axis beam tilt in the near-endfire direction. It discusses a novel technique of combining endfire radiation wearable planar antennas with AMCs for improving the antenna tolerance when positioned on the human body. A conventional planar Yagi antenna was combined with single- and double-layered AMC surfaces to change the direction of radiation from bidirectional-endfire to near-endfire off-axis beam-tilt radiation. The free-space and on-body analyses were performed using the CST MWS voxel model for common antenna properties, such as return loss, gain, frequency shifting, radiation efficiency, and peak specific absorption rate (SAR) level considering body-worn applications. The fabricated double-layered AMC-backed Yagi antenna prototype on latex substrate demonstrates acceptable return loss bandwidth and endfire gain to be used for wireless body area network (WBAN) applications in 2.4 GHz ISM band.
Patch-based geometric texture synthesis (2013)

Inspired by the results of recent studies on the perception of geometric textures, we present a patch-based geometric synthesis algorithm that mimics observed synthesis strategies. Our synthesis process first constructs an overlapping grid of copies of the exemplar, and then culls individual motifs based on overlaps and the enforcement of minimum distances.
Edible wafers need physics (1994)

The food industry is changing rapidly. What was once a high-labour, low-technology environment has become a highly automated mass-production business. In becoming so, the food industry can now present physicists with challenges equal to anything that they face in industries more usually associated with physics, such as electronics, instrumentation and power generation. First, the final product has to be eaten and enjoyed by the purchaser. This places great demands on taste, texture and hygiene. Second, the raw materials are always changing: every electron is identical, but every potato is different, while crisps are expected to remain the same.
Weighted Pointer: Error-aware Gaze-based Interaction through Fallback Modalities (2022)

Gaze-based interaction is a fast and ergonomic type of hands-free interaction that is often used with augmented and virtual reality when pointing at targets. Such interaction, however, can be cumbersome whenever user, tracking, or environmental factors cause eye tracking errors. Recent research has suggested that fallback modalities could be leveraged to ensure stable interaction irrespective of the current level of eye tracking error. This work thus presents Weighted Pointer interaction, a collection of error-aware pointing techniques that determine whether pointing should be performed by gaze, a fallback modality, or a combination of the two, depending on the level of eye tracking error that is present. These techniques enable users to accurately point at targets when eye tracking is accurate and inaccurate. A virtual reality target selection study demonstrated that Weighted Pointer techniques were more performant and preferred over techniques that required the use of manual modality switching.
Aerosol Flow Reactor Method for the Synthesis of Multicomponent Drug Nano- and Microparticles (2007)

This chapter presents the novel aerosol flow reactor method for the synthesis of single- and multicomponent nanoparticles as well as nanostructured, micronsized particles. In the aerosol flow reactor method, the solution containing solute(s) is atomized to produce droplets that are transferred with the aid of a carrier gas to a heated flow reactor. The chapter discusses the formation of the polymeric nanoparticles from several solvents. It also discusses the preparation of the composite powders using l-leucine to increase the stability of powders. The incorporation of l-leucine modifies particle surface structure and changes, for instance, spherical particles to wrinkled ones depending on the l-leucine content. A drying particle expands while water molecules penetrate through the l-leucine film and after complete removal of water the film collapses to give wrinkled morphology. The chapter describes the control of the polymer Eudragit® L100 nanoparticle morphology when produced from different solvent media.
Validation of Travel Simulation Model for a Crawler Excavator and Influence of Vehicle Posture on Traveling Behavior (2021)

Crawlers are widely used as construction vehicles that require high trafficability in off-road situations. When being operated on a slope, such vehicles often slip due to skidding between the crawlers and the soil. When the posture of the front structures on a hydraulic excavator changes, the amount of skidding also dynamically changes. A highly skilled operator must deftly adjust the left and right crawlers to follow a target trajectory. Since the construction industry requires the development of assisted and autonomous technologies, a crawler-traveling simulation model on soft ground is needed. We established a traveling simulation model on a slope by terramechanics for a crawler vehicle with a changing center of gravity. The ground parameters in our simulation model were identified using the actual test data of the crawler vehicle. Then we compared the simulated, traveling results that were identified with actual vehicle experiments and verified that our simulation methodology reproduced the skidding of a crawler vehicle on off-road slopes. In addition, several case studies were performed to understand the effect of the changing center of gravity on the traveling trajectory.
FIGURE 1 from Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma (2023)

&lt;p&gt;Study procedures. Participant study procedures including cell collection/manufacturing timeline as well as infusion schedule from eligibility confirmation onward.&lt;/p&gt;
Towards development of an analytical model relating FPGA architecture parameters to routability (2013)

We present an analytical model relating FPGA architectural parameters to the routability of the FPGA. The inputs to the model include the channel width and the connection and the switch block flexibilities. The output is an estimate of the proportion of nets in a large circuit that can be expected to be successfully routed on the FPGA. We assume that the circuit is routed to the FPGA using a single-step combined global/detailed router. We show that the model correctly predicts routability trends. We also present an example application to demonstrate that this model may be a valuable tool for FPGA architects. When combined with the earlier works on analytical modeling, our model can be used to quickly predict the routability without going through any stage of an expensive CAD flow. We envisage that this model will benefit FPGA architecture designers and vendors to quickly evaluate FPGA routing fabrics.
Predicting Host Immune Cell Dynamics and Key Disease-Associated Genes Using Tissue Transcriptional Profiles (2019)

Motivation: Immune cell dynamics is a critical factor of disease-associated pathology (immunopathology) that also impacts the levels of mRNAs in diseased tissue. Deconvolution algorithms attempt to infer cell quantities in a tissue/organ sample based on gene expression profiles and are often evaluated using artificial, non-complex samples. Their accuracy on estimating cell counts given temporal tissue gene expression data remains not well characterized and has never been characterized when using diseased lung. Further, how to remove the effects of cell migration on transcript counts to improve discovery of disease factors is an open question. Results: Four cell count inference (i.e., deconvolution) tools are evaluated using microarray data from influenza-infected lung sampled at several time points post-infection. The analysis finds that inferred cell quantities are accurate only for select cell types and there is a tendency for algorithms to have a good relative fit (R 2 ) but a poor absolute fit (normalized mean squared error; NMSE), which suggests systemic biases exist. Nonetheless, using cell fraction estimates to adjust gene expression data, we show that genes associated with influenza virus replication and increased infection pathology are more likely to be identified as significant than when applying traditional statistical tests.
Design and Fabrication of an Arm Exoskeleton for Aim Stabilization (2013)

Accurately aiming and firing a pistol requires a steady hand. While many devices can steady a shooter’s arm or hand by restricting movement or degrees-of-freedom, few devices actively reduce involuntary tremors while allowing larger voluntary aiming movements. This paper details the design and fabrication of an arm exoskeleton that can actively damp arm tremors while allowing voluntary aiming movements. The device allows five degrees-of-freedom and is very lightweight due to its cable-driven architecture and use of carbon fiber composite materials. Tremorous movement is filtered out from voluntary motion, and an adaptive algorithm provides a tremor-cancelling signal to the cable control motors.
One-year myopia control efficacy of spectacle lenses with aspherical lenslets (2021)

ChiCTR1800017683.