gebhart/patrepeval huggingface dataset:
Endothelial targeting with C1-inhibitor reduces complement activationin vitroand duringex vivoreperfusion of pig liver (2001)

Tissue damage during cold storage and reperfusion remains a major obstacle to wider use of transplantation. Vascular endothelial cells and complement activation are thought to be involved in the inflammatory reactions following reperfusion, so endothelial targeting of complement inhibitors is of great interest. Using an in vitro model of human umbilical vein endothelial cells (HUVEC) cold storage and an animal model of ex vivo liver reperfusion after cold ischaemia, we assessed the effect of C1-INH on cell functions and liver damage. We found that in vitro C1-INH bound to HUVEC in a manner depending on the duration of cold storage. Cell-bound C1-INH was functionally active since retained the ability to inhibit exogenous C1s. To assess the ability of cell-bound C1-INH to prevent complement activation during organ reperfusion, we added C1-INH to the preservation solution in an animal model of extracorporeal liver reperfusion. Ex vivo liver reperfusion after 8 h of cold ischaemia resulted in plasma C3 activation and reduction of total serum haemolytic activity, and at tissue level deposition of C3 associated with variable level of inflammatory cell infiltration and tissue damage. These findings were reduced when livers were stored in preservation solution containing C1-INH. Immunohistochemical analysis of C1-INH-treated livers showed immunoreactivity localized on the sinusoidal pole of the liver trabeculae, linked to sinusoidal endothelium, so it is likely that the protective effect was due to C1-INH retained by the livers. These results suggest that adding C1-INH to the preservation solution may be useful to reduce complement activation and tissue injury during the reperfusion of an ischaemic liver.
Nucleation and Growth during Al2O3 Atomic Layer Deposition on Polymers (2005)

Nucleation and growth during Al2O3 atomic layer deposition (ALD) were explored on a variety of polymer films at 85 °C. Al2O3 ALD was performed using sequential exposures of Al(CH3)3 [trimethylaluminum (TMA)] and H2O. The polymer films were polystyrene (PS), polypropylene (PP), poly(methyl methacrylate) (PMMA), polyethylene (PE), and poly(vinyl chloride) (PVC). These polymer films were prepared by spin-coating onto the surface of a quartz crystal microbalance (QCM) sensor or the surface of a Si(100) wafer. Al2O3 ALD during the sequential TMA and H2O exposures was monitored in situ on the various polymers using the QCM. The QCM measurements revealed distinct differences for each polymer in the initial nucleation period during Al2O3 ALD. Following the initial nucleation period, linear Al2O3 ALD growth was observed on all the polymers. The thickness of the Al2O3 ALD films was also characterized by ex situ surface profilometry. Based on the QCM measurements and recent FTIR measurements of Al2O3 ALD on low-density PE, a model is proposed for Al2O3 ALD nucleation and growth on polymers. This model is based on the adsorption of TMA onto the surface and absorption into the near-surface region of the polymer. The adsorbed and absorbed TMA is then available for subsequent reaction with the H2O exposure. This model for Al2O3 ALD does not require specific chemical groups on the polymer surface to initiate Al2O3 ALD. This model should be valuable to understand and optimize the use of these Al2O3 ALD films as seed layers and gas diffusion barriers on polymers.
Transcutaneous localization of arterial meeding by two dimensional ultrasonic imaging of tissue vibrations (2004)

Arterial bleeding into a free space is known to cause local vibrations in tissue. To study the effectiveness of utilizing these tissue vibrations in localizing the site of arterial bleeding, we have developed an algorithm for ultrasonically imaging these tissue vibrations. Simulation results indicate that our algorithm can correctly detect vibrations in the presence of pulsatile wall motion, blood flow and noise with the sensitivity of 96% and specificity of 99%. Preliminary results from an animal study indicate that our algorithm can detect vibrations from bleeding arteries as well as from organs such as liver and spleen.
Coarse-to-fine Humanoid Motion Planning Using COM Feasible Region and Achievement of Humanoids Ladder Climbing and Transition (2018)

Trajectory planning for humanoid robots requires satisfying various constraints such as balance, contact, joint limitation, kinematics, and collision. To obtain trajectory efficiently, related research has integrated coarse motion planning to fine full-body trajectory generation. In this paper, we propose a humanoid motion planner satisfying various constraints based on key pose generation by exploiting center-of-mass (COM) feasible region (CFR): (a) We show a method to project approximately balance constraints of statics and dynamics into CFR. (b) We propose a key pose generation capable of considering swing and support phase to satisfy asymptotically CFR constraint while satisfying kinematics constraints. (c) We show a method to obtain full-body trajectory by interpolating obtained key pose. We validate our proposed method through evaluations, in which the robot performs locomotion tasks related to ladder climbing under the stringent constraints, and experiments, in which the real robot achieves ladder motion.
Validation of an Immunodiagnostic Assay for Detection of 13 Streptococcus pneumoniae Serotype-Specific Polysaccharides in Human Urine (2012)

To improve the clinical diagnosis of pneumococcal infection in bacteremic and nonbacteremic community-acquired pneumonia (CAP), a Luminex technology-based multiplex urinary antigen detection (UAD) diagnostic assay was developed and validated. The UAD assay can simultaneously detect 13 different serotypes of Streptococcus pneumoniae by capturing serotype-specific S. pneumoniae polysaccharides (PnPSs) secreted in human urine. Assay specificity is achieved by capturing the polysaccharides with serotype-specific monoclonal antibodies (MAbs) on spectrally unique microspheres. Positivity for each serotype was based on positivity cutoff values calculated from a standard curve run on each assay plate together with positive- and negative-control urine samples. The assay is highly specific, since significant signals are detected only when each PnPS was paired with its homologous MAb-coated microspheres. Validation experiments demonstrated excellent accuracy and precision. The UAD assay and corresponding positivity cutoff values were clinically validated by assessing 776 urine specimens obtained from patients with X-ray-confirmed CAP. The UAD assay demonstrated 97% sensitivity and 100% specificity using samples obtained from patients with bacteremic, blood culture-positive CAP. Importantly, the UAD assay identified Streptococcus pneumoniae (13 serotypes) in a proportion of individuals with nonbacteremic CAP, a patient population for which the pneumococcal etiology of CAP was previously difficult to assess. Therefore, the UAD assay provides a specific, noninvasive, sensitive, and reproducible tool to support vaccine efficacy as well as epidemiological evaluation of pneumococcal disease, including CAP, in adults.
Reactive Extrusion of Maleic-Anhydride-Grafted Polypropylene by Torque Rheometer and Its Application as Compatibilizer (2021)

This study is based upon the functionalization of polypropylene (PP) by radical polymerization to optimize its properties by influencing its molecular weight. Grafting of PP was done at different concentrations of maleic anhydride (MAH) and benzoyl peroxide (BPO). The effect on viscosity during and after the reaction was studied by torque rheometer and melt flow index. Results showed that a higher concentration of BPO led to excessive side-chain reactions. At a high percentage of grafting, lower molecular weight product was produced, which was analyzed by viscosity change during and after the reaction. Percentage crystallinity increased by grafting due to the shorter chains, which consequently led to an improvement in the chain's packing. Prepared Maleic anhydride grafted polypropylene (MAH-g-PP) enhanced interactions in PP-PET blends caused a partially homogeneous blend with less voids.
Water-Based Muds and Shale Interactions (2001)

Abstract A simple and robust indentation test has been found to be useful in evaluating shale additive performance, providing results that correlate strongly with those of the much more time-intensive high pressure hollow cylinder tests. This method has been used to evaluate shale inhibitors and many other common drilling fluids additives. Experiments have been carried out with carefully prepared samples of Pierre 2 Shale aged in different formulations. A ranking of shale strength versus mud formulation has been constructed for the following water based fluid additives: glycols (soluble and with Cloud Point), salts (organic and inorganic), gypsum, and polymers (Xanthan Gum, cationic, polyanionic cellulose). Based on the X-ray diffraction pattern analysis of aged shale samples a shape factor has been proposed to identify effective additives.
CTR plasma engineering studies. Annual progress report, October 1, 1977--October 31, 1978 (1978)

Fusion engineering studies are described that relate to three areas of fusion reactor development. Techniques to examine high-energy alpha transport in tokamak plasmas are described along with results relative to wall bombardment and resultant plasma contamination. Calculations for an experiment planned for TFTR to verify this theory are also included. Studies of plasma heating, fueling and stability for a field-reversed mirror are described that have lead to the concept of a small (less than 10 MWe) reactor labeled SAFFIRE. Finally methods are proposed to improve the efficiency of a reversed-field pinch by extending its burn through refueling and energy-loss control.
Effects of gravity on cocurrent two-phase gas-liquid flows through packed columns (2001)

This work presents the experimental results of research on the influence of gravity on flow pattern transitions, pressure drop and flow characteristics for cocurrent gas-liquid two-phase flow through packed columns. The flow pattern transition data indicates that the pulse flow regime exists over a wider range of gas and liquid flow rates under reduced gravity conditions compared to normal gravity cocurrent down-flow. This is illustrated by comparing the flow regime transitions found in reduced gravity with the transitions predicted by Talmor. Next, the effect of gravity on the total pressure drop in a packed column is shown to depend on the flow regime. The difference is roughly equivalent to the liquid static head for bubbly flow but begins to decrease at the onset of pulse flow. As the spray flow regime is approached by increasing the gas to liquid ratio, the effect of gravity on pressure drop becomes negligible. Finally, gravity tends to suppress the amplitude of each pressure pulse. An example of this phenomenon is presented.
Anomalous occupancy sensor behavior detection in connected indoor lighting systems (2019)

We consider the problem of classifying anomalous occupancy sensor behavior in connected indoor lighting systems. Anomalous occupancy sensor behavior may occur in the form of either a high number of false alarms (type-1 anomalies) or missed detection (type-2 anomalies). We consider a supervised machine learning approach to determine whether the detection signal of an occupancy sensor is normal, or exhibits type-1 or type-2 anomalies. We devise occupancy signal features in the time and frequency domains and employ a random forest classifier to perform 3-class classification. The proposed method is evaluated using motion sensor data from an office building, and is shown to have higher true positive rate and a lower false positive rate in comparison to an unsupervised k-means method and a random forest classifier with a single signal energy feature.
Synthesis and Investigation of the V‐shaped Tröger′s Base Derivatives as Hole‐transporting Materials (2016)

V-shaped Tröger's base core has been investigated as a central linking unit in the synthesis of new charge-transporting materials for optoelectronic applications. The studied molecules have been synthesized in two steps from relatively inexpensive starting materials, and demonstrate high glass transition temperatures, good stability of the amorphous state, and comparatively high hole drift mobility (up to 0.011 cm(2) V(-1) s(-1) ).
Meta Self-training for Few-shot Neural Sequence Labeling (2021)

Neural sequence labeling is widely adopted for many Natural Language Processing (NLP) tasks, such as Named Entity Recognition (NER) and slot tagging for dialog systems and semantic parsing. Recent advances with large-scale pre-trained language models have shown remarkable success in these tasks when fine-tuned on large amounts of task-specific labeled data. However, obtaining such large-scale labeled training data is not only costly, but also may not be feasible in many sensitive user applications due to data access and privacy constraints. This is exacerbated for sequence labeling tasks requiring such annotations at token-level. In this work, we develop techniques to address the label scarcity challenge for neural sequence labeling models. Specifically, we propose a meta self-training framework which leverages very few manually annotated labels for training neural sequence models. While self-training serves as an effective mechanism to learn from large amounts of unlabeled data via iterative knowledge exchange -- meta-learning helps in adaptive sample re-weighting to mitigate error propagation from noisy pseudo-labels. Extensive experiments on six benchmark datasets including two for massive multilingual NER and four slot tagging datasets for task-oriented dialog systems demonstrate the effectiveness of our method. With only 10 labeled examples for each class in each task, the proposed method achieves 10% improvement over state-of-the-art methods demonstrating its effectiveness for limited training labels regime.
Replacement of a conserved arginine in the assembly domain of ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit interferes with holoenzyme formation. (1992)

In higher plants the small subunit (S) of ribulose-1,5-bisphosphate carboxylase/oxygenase (ribulose-P2 carboxylase, EC 4.1.1.39) contains a segment of 16 amino acids which is absent from cyanobacterial S. This segment connecting two beta sheets has been shown, by crystallographic analysis, to form a hairpin loop. The quaternary structure of ribulose-P2 carboxylase indicates several S to large subunit (L) interactions. Eleven of 22 residues within the loop form the interface with 20 residues from two different L dimers. Eight of the loop residues are involved in hydrogen bonds, salt links, and hydrophobic interactions. To test the hypothesis, whether this loop had a function in the assembly of L and S into the hexadecameric enzyme, 6 amino acids within the loop were modified by site-directed mutagenesis of the pea rbcS-3A gene. All substituted S were imported by isolated chloroplasts from pea with wild type efficiency. Mutants E54-R, H55-A, P59-A, D63-G, D63-L, and Y66-A were assembly-competent, indicating that changes of side chains at these positions are tolerated. Replacement of arginine 53, whose side chain forms H-bonds with L residues Y226 and G261, with glutamate completely abolished assembly into holoenzyme. We suggest that arginine 53 in S is essential for ribulose-P2 carboxylase quaternary structure in higher plants.
Holographic Optical Elements For SLM Defect Removal And For Optical Interconnects (1988)

Holographic Optical Elements (HOE&apos;s) of space-variant impulse response have been designed and generated using a computerized optical system. HOE&apos;s made of dichromated gelatin have been produced and used for spatial light modulator defect removal and for optical interconnects. Experimental performance and characteristics are presented.
Figure S2 from STimulator of INterferon Genes Agonism Accelerates Antitumor Activity in Poorly Immunogenic Tumors (2023)

&lt;p&gt;Supplemental Figure 2: STING agonists stimulate cytokines in tumor, plasma and peripheral tissues following IT dosing.&lt;/p&gt;
Initial feasibility studies using single‐shot EPI for the detection of focal liver lesions (1994)

Echo planar MR imaging (EPI) has been developed to completely eliminate motion artifacts and is currently being prepared for implementation into clinical MR systems. Thus, the purpose of this study was to evaluate the clinical utility of EPI in the detection of focal liver lesions and to compare EPI with in the detection of focal liver lesions and to compare EPI with contrast-enhanced CT. EPI studies were performed on an experimental 1.0 Tesla whole body system using fat-suppressed single-shot spin echo (SE) and inversion recovery (IR) pulse sequences. A total of 26 liver tumors in 12 patients scheduled for liver resection were prospectively examined and correlated with intraoperative ultrasound, surgery, and pathology as the gold standard. Quantitative analysis of EPI was performed by means of liver signal-to-noise and tumor-liver contrast-to-noise calculations. Diagnostic performance compared with contrast-enhanced CT was assessed by means of ROC analysis. Lesion-liver contrast was highest with EPI SE at a TE-time of 70 ms and this technique showed best lesion detectability as measured by area under curve (AUC) values. Among EPI techniques, the IR sequence with an inversion time of 300 ms to null the liver signal showed high lesion-liver contrast but all four reviewers reported problems assessing liver anatomy. Improved EPI techniques may prove useful for screening of focal liver lesions.
Systematic review: the efficacy of herbal therapy in inflammatory bowel disease (2013)

Randomised controlled trials of herbal therapy for the treatment of IBD show encouraging results but studies remain limited and heterogenous. Larger controlled studies with stricter endpoints and better-defined patient groups are required to obtain more conclusive results on the use of CAM therapies in IBD.
A major role for TLR8 in the recognition of vaccinia viral DNA by murine pDC? (2010)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Do open resources encourage entry into the millimeter wave cellular service market? (2016)

The resource usage model for millimeter wave bands has been the subject of considerable debate. The massive bandwidth, highly directional antennas, high penetration loss and susceptibility to shadowing in these bands suggest certain advantages to spectrum and infrastructure sharing. In particular, resources that are "open", such as unlicensed spectrum or a deployment of base stations open to all service providers, may offer greater gains in mmWave bands than at conventional cellular frequencies. However, even when sharing is technically beneficial (as recent research in this area suggests that it is), it may not be profitable. In this paper, both the technical and economic implications of resource sharing in millimeter wave networks are studied. Millimeter wave service is considered in the economic framework of a network good, where consumers' utility depends on the network size. Detailed network simulations are used to understand data rates, profit, and demand for millimeter wave service, with and without open resources. The results suggest that "open" deployments of neutral small cells that serve subscribers of any service provider encourage market entry by making it easier for networks to reach critical mass, more than "open" (unlicensed) spectrum would.
Data Supplement from Comprehensive Biomarker Analysis and Final Efficacy Results of Sorafenib in the BATTLE Trial (2023)

&lt;p&gt;Supplementary Material and Methods&lt;/p&gt;
Large system analysis of power minimization in multiuser MISO downlink with transmit-side channel correlation (2012)

This paper investigates a joint power control and beamformer design in a correlated multiuser MISO downlink to minimize the weighted transmit power. We firstly review a distributed fixed-point iterative algorithm. This algorithm, though converging to the optimal solution, requires instantaneous power iteration. In order to reduce the implementation complexity, we leverage tools from random matrix theory to derive an asymptotically optimal solution requiring only statistical channel information. In addition, the effect of transmit-side channel correlation on the large system analysis is studied, and a distributed algorithm computing the asymptotically optimal power is proposed. In this algorithm, the asymptotically optimal power is updated according to channel statistics, and thus no instantaneous power update is needed for computing the asymptotically optimal beamformer.
A comprehensive model of human erythrocyte metabolism: extensions to include pH effects. (1990)

A mathematical model of the human erythrocyte, which accounts both for metabolism of the cell and its interactions with the environment, has been constructed. The pH dependence of enzyme activities is added to a previous model, which accounts for glycolysis, pentose phosphate pathway, nucleotide synthesis, membrane transport, osmotic balance, and conditions of electroneutrality. The extended model predicts well the dynamic behavior of the red cell in response to glucose depletion and pH variation.
La course inhibe l'osteopenie induite par la castration chez le jeune rat (1996)

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The mechanical and thermal properties of alumina filled epoxy (2006)

This article describes the thermal and mechanical behavior of alumina-filled epoxy composites. The epoxy matrix was reinforced with increasing amount of alumina particles in the range of 10-30% by weight using resin transfer molding technique. From the flexural test results, it was observed that the flexural modulus increases with increasing a-alumina content from 10 to 30 wt% with 30 wt% of a-alumina content recorded the highest value of flexural modulus. The DMA result reveals that the highest glass transition temperature (Tg) was recorded at 30 wt% alumina content. It was also found that the 30 wt% alumina content recorded the highest value of storage modulus. The weight loss profile and thermal stability from TGA results show that the thermal stability increases with increasing alumina content. The morphology of the fracture surface also be studied using FESEM.
Privacy Frost: A User-Oriented Data Anonymization Tool (2011)

A challenging task in privacy protection for public data is to realize an algorithm that generalizes a table according to requirements of a data user. In this paper, we propose an anonymization scheme for generating a k-anonymous and l-diverse table, and show evaluation results using three different tables. Our scheme is based on both top-down and bottom-up approaches for full-domain and partial-domain generalization, and the requirements are automatically incorporated into the generated table. The generated table meets user's requirements and can be employed in the services provided by users without any modification or evaluation.
Two novel collagen based dura repair membranes: solutions for the multifaceted needs in duraplasty part ii: in vivo rabbit duraplasty studies (2016)

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