gebhart/patrepeval huggingface dataset:
Correction: Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection (2020)

After this article In Fig 4B, the first and fourth panels in the right column (rnf-5(RNAi)) appear similar. The authors noted that these panels were duplicated due to errors in figure preparation. An updated version of Fig 4 is provided here in which the duplicates are removed.
The DirecNet&#x2122; standard reference architecture: A roadmap for interoperability (2011)

The Open Group's DirecNet™ Task Force is an industry-led consortium consisting of twelve major aerospace firms. Its goal is to develop a vendor-neutral interoperability standard for a next generation directional networking waveform. The waveform developed will be IP-enabled, support the use of directional high bandwidth links, and the use of ad hoc mobile mesh networking. A key objective of the Task Force is to bring the advantages of commercial interoperability and standards development processes into the government arena. At this time, the Task Force has completed and released an overview and reference architecture volume as well the standard for a bandwidth-efficient PHY layer. This paper reviews the selected DirecNet architecture and on-going technical work of the consortium.
R‐Wave Detection by Subcutaneous ECG. Possible Use for Analyzing R‐R Variability (2001)

SFFECG might be a helpful adjunct in implantable device systems for detection of R waves and may be used for measurement of R to R variability.
Abstract 82: De novo Mutation Burden Reveals Novel Molecular Subtypes of Non-syndromic Craniosynostosis (2018)

PURPOSE: Craniosynostosis is one of the most frequent congenital malformations encountered by the craniofacial surgeon. 15% of cases are syndromic and with well-characterized genetic etiologies, however non-syndromic cases account for 85% of the burden of disease. Despite this prevalence, the genetic etiology of non-syndromic craniosynsotosis (NSC) is largely unexplored. More than 95% of NSC is sporadic, suggesting a role for de novo mutations. By comparing the burden of de novo mutations in NSC cases and controls, we sought to identify those sporadic mutations causing craniosynostosis. METHODS: We performed whole exome sequencing on a cohort of 384 probands with NSC affecting the sagittal (n = 237), metopic (n = 136), combined sagittal and metopic (n = 10), or combined sagittal and coronal (n = 1) sutures. These included 291 complete parent– offspring trios, and 50 probands from kindreds with multiple NSC-affected family members. Of the targeted bases, 96.6% had 8 or more independent reads, and 88.6% had 20 or more. In parallel, we analyzed de novo variants in parents and healthy siblings of 1,789 autism probands from the Simons simplex collection sequenced on the same platform. RESULTS: Exome sequencing of 291 parent–offspring trios with midline NSC revealed 15 probands with heterozygous damaging de novo mutations in 12 negative regulators of Wnt, BMP, and Ras/ERK signaling (10.9-fold enrichment, P = 2.4 x 10−11). SMAD6 had 4 de novo and 14 transmitted mutations (P < 10–21), strongly replicating our previous association of SMAD6 to midline NSC. Four familial NSC kindreds had mutations in genes previously implicated in syndromic disease, including TWIST1, TCF12, ERF and MSX2. Collectively, these mutations explain 10% of cases studied. Mutations are predominantly loss-of-function, implicating haploinsufficiency as a frequent mechanism of disease pathogenesis. CONCLUSIONS: These findings implicate several new genes in NSC and demonstrate related pathophysiology of common non-syndromic and rare syndromic craniosynostoses. The results continue to support substantial genetic heterogeneity in NSC, and identify novel molecular subtypes of disease. These findings have implications for diagnosis, risk of recurrence, and risk of adverse neurodevelopmental outcomes. A.T. Timberlake: None. C.G. Furey: None. J. Choi: None. C. Nelson-Williams: None. D.M. Steinbacher: None. D. Larysz: None. J.A. Persing: None. R.P. Lifton: None.
Supplementary Figure 1 from Robust Antitumor Immunity in a Patient with Metastatic Colorectal Cancer Treated with Cytotoxic Regimens (2023)

&lt;p&gt;Phenotypic analysis of the CD4 compartment in patients with CRLM&lt;/p&gt;
Accelerator-based boron neutron capture therapy facility at the Helsinki University Hospital (2021)

Boron neutron capture therapy (BNCT) is a unique type of radiation therapy that enables biological targeting of cancer at the cellular level. BNCT has been used to treat cancer with a two-step proc...
Estimating remaining BDV and life expectancy for stator winding insulation of rotating machines by using nondestructive insulation diagnostic data (2004)

We have investigated an appropriate life expectancy estimating method of the epoxy resin-rich insulation system (Fuji F-class Stabilastic insulation system). We have already collected the BVD and the nondestructive insulation diagnostic data from 30 or more units of the rotating electric machines provided epoxy resin-rich insulation system with the rated voltage of 3.3 to 11 kV. We have performed a multivariate analysis on the BVD and the nondestructive insulation diagnostic data of these coils in this time, and have established the estimating method for the remaining BVD and the life expectancy. On the basis of compared results of the measured values with the estimated values, it was proven that this estimating method provides enough accuracy for the actual use.
Safe and Rapid Synthesis and Utilization of 2-Azidopyridine and Related Derivativesvia Continuous Flow Diazotization (2023)

Abstract: Aril azides are popular reagents in the laboratory, but their explosive properties prevent their larger-scale application. The safety risk is even greater for N-heterocyclic azides, which are rarely studied. Flow chemistry can be an effective tool in the synthesis and utilization of dangerous and explosive chemicals. In small-diameter flow reactors, good heat and mass transfer prevent local hot spots and side reactions, and since only small amounts of hazardous chemicals are present at any time, the potential danger is reduced in the event of an accident. In this work, the safe syntheses of 9 different 2-azidopyridine, 2-azidopyrimidine and 2 azidoquinoxaline derivatives were successfully achieved within the continuous-flow system. In most cases, simple work-up resulted in pure products. In-line extractive work-up was also implemented, which allowed us to transform 2-azidopyridine in a subsequent Staudinger reaction in a connected flow reactor, without manual handling of the hazardous azide.
Complete chloroplast genome of Oncidium Gower Ramsey and evaluation of molecular markers for identification and breeding in Oncidiinae (2010)

In this report, we used Phalaenopsis. aphrodite as a prototype for primer design to complete the Onc. Gower Ramsey genome sequence. Gene annotation showed that most of the ndh genes inOncidiinae, with the exception of ndhE, are non-functional. This phenomenon was observed in all of the Oncidiinae species tested. The genes and chloroplast DNA regions that would be the most useful for phylogenetic analysis were determined to be the trnHGUG-psbA and the trnFGAA-ndhJ regions. We conclude that complete chloroplast genome information is useful for plant phylogenetic and evolutionary studies in Oncidium with applications for breeding and variety identification.
A Hybrid Low-Cost Bandpass Filter With SAW Resonators and External Lumped Inductors Using a Dual-Coupling Scheme (2020)

A class of hybrid low-cost bandpass filter (BPF) with only two kinds of circuit components, straightforward design procedure, and miniaturized circuit footprint is presented. The proposed BPF is based on a hybrid module composed of one type of surface-acoustic-wave (SAW) resonator and one external lumped inductor. Compared with traditional SAW-resonator-based BPF devices, the use of a single-SAW-resonator model for its design reduces the cost and complexity by avoiding the need for well-matched SAW-resonator pairs. The engineered filter topology consists of a dual-path coupling scheme, in which one coupling path is simply a series-type SAW resonator and another path is made up of two SAW resonators that are intercoupled by means of an external inductor in the middle. Such coupling architecture generates two additional transmission zeros (TZs) that allow to increase the out-of-band power-rejection levels and enlarge the stopband bandwidth. A circuit analysis based on the even-/odd-mode method is applied to derive its equivalent circuit that can be directly matched to a conventional transversal filter topology. The obtained equivalent circuit readily illustrates the operational mechanisms of the proposed filter principle in terms of reflection zeros and TZs. Subsequently, the quality factors of its even- and odd-mode-subnetwork resonators are analytically derived, and the obtained numerical results determine the tradeoff existing when choosing the external-inductor value among various performance metrics. For experimental validation purposes, two 418-MHz BPF prototypes formed by one and two in-series-cascade-connected second-order filtering units, respectively, are manufactured and tested. The circuit footprints of these filters are largely reduced by using a three-layer lamination technique for their physical implementations. The measured results show sharp-rejection filtering responses and are in close agreement with the theoretical predictions.
Revealing in real-time a multistep assembly mechanism for SV40 virus-like particles (2020)

Many viruses use their genome as template for self-assembly into an infectious particle. However, this reaction remains elusive because of the transient nature of intermediate structures. To elucidate this process, optical tweezers and acoustic force spectroscopy are used to follow viral assembly in real time. Using Simian virus 40 (SV40) virus-like particles as model system, we reveal a multistep assembly mechanism. Initially, binding of VP1 pentamers to DNA leads to a significantly decreased persistence length. Moreover, the pentamers seem able to stabilize DNA loops. Next, formation of interpentamer interactions results in intermediate structures with reduced contour length. These structures stabilize into objects that permanently decrease the contour length to a degree consistent with DNA compaction in wild-type SV40. These data indicate that a multistep mechanism leads to fully assembled cross-linked SV40 particles. SV40 is studied as drug delivery system. Our insights can help optimize packaging of therapeutic agents in these particles.
A Novel Cure Reaction Model Fitting Technique Based on DSC Scans (2005)

A numerical methodology has been developed to fit cure kinetic reaction models based on DSC scans only, and not isothermally as traditionally done. A non-linear least squares Levenberg-Marquardt algorithm was used to fit the reaction rates with the autocatalytic Kamal-Sourour kinetic model. The technique avoids the use of isothermal DSC data which causes additional problems in the fitting procedure, such as oscillations in low temperature scans or lost information for fast reaction materials at high process temperature scans. The new methodology is based on a series expansion of the kinetic parameters as a function of temperature. The technique was first tested with the vulcanization process of silicone rubber which is dominated by a cross-linking single-event curing reaction. The method was also tested with phenolic formulations, which according to the hardener, present one or two reaction events. Additionally, the glass transition temperature, of these materials, during the curing process is mostly below the vitrification line, thus, diffusion effects can be neglected. The results show good agreement between the experimental DSC scans and the predicted reaction rates. The technique presented in this paper is intended for use in process simulation, and not to infer kinetic reaction mechanisms.
Rotational isomerism in 6-β-D-glucopyranosides of methyl-1,2,6-thiadiazin-3(2H)-one 1,1-dioxides (1990)

Glucopyranosides of methyl-1,2,6-thiadiazin-3(2H)-one 1,1-dioxides have been synthesized and their rotational isomerism studied. Two of them exist, in solution, as mixtures of syn : anti rotamers, at room temperature. In the case of the diglucoside, the barriers to rotation about both glycosidic bonds have been calculated by dynamic 13C NMR.
Why Are We Still Reporting Mass Accuracy in Parts per Million (ppm)? (2020)

ADVERTISEMENT RETURN TO ISSUEPREVLetter to EditorNEXTWhy Are We Still Reporting Mass Accuracy in Parts per Million (ppm)?Robert B. Cody*Robert B. CodyJEOL USA, Inc., Peabody, Massachusetts 01960, United States*Email: [email protected]More by Robert B. Codyhttp://orcid.org/0000-0002-6624-8530Cite this: J. Am. Soc. Mass Spectrom. 2020, 31, 4, 1004–1005Publication Date (Web):March 18, 2020Publication History Received31 December 2019Accepted12 March 2020Revised11 March 2020Published online18 March 2020Published inissue 1 April 2020https://doi.org/10.1021/jasms.9b00150Copyright © 2020 American Society for Mass Spectrometry. Published by the American Chemical Society. All rights reserved.Request reuse permissionsArticle Views830Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ions,Isotopes,Mass spectrometry,Nuclear magnetic resonance spectroscopy,Spectroscopy Get e-Alerts
NICE (2014)

We present a novel method of layer 2 network topology discovery for Ethernet LANs through the coordinated operation of endpoints/hosts, part of a research project called NICE (Network Introspection by Collaborating Endpoints). Networks are constantly changing, including Ethernet LANs -- machines come and go, network hardware fails, switches are rewired, equipment is reconfigured. The layer 2 network represents a moving target, both for the attacker and the defender alike. It is necessary to understand the network, both before and during these changes. Existing network management approaches based on collecting and correlating SNMP data from managed layer 2 devices cannot see the complete picture of the network and cannot see all changes as they occur, in particular changes related to unmanaged devices. NICE is able discover more information about the topology, including unmanaged devices, without the assistance of traditional network management tools and protocols. NICE requires no administrative access to networking hardware, is multi-platform, and discovers both consumer and enterprise layer 2 devices. The novel contributions of this paper include a layer 2 mapping protocol that does not require SNMP access nor MAC address spoofing, and a working method to discover and locate non-NICE devices in the topology, improving upon existing research. We have performed extensive experimentation to validate our techniques and provide a comparison to existing research.
Photo-on-Demand Synthesis of Vilsmeier Reagents with Chloroform and Their Applications to One-Pot Organic Syntheses (2021)

The Vilsmeier reagent (VR), first reported a century ago, is a versatile reagent in a variety of organic reactions. It is used extensively in formylation reactions. However, the synthesis of VR generally requires highly toxic and corrosive reagents such as POCl<sub>3</sub>, SOCl<sub>2</sub>, or COCl<sub>2</sub>. In this study, we found that VR is readily obtained from a CHCl<sub>3</sub> solution containing <i>N</i>,<i>N</i>-dimethylformamide or <i>N</i>,<i>N</i>-dimethylacetamide upon photo-irradiation under O<sub>2</sub> bubbling. The corresponding Vilsmeier reagents were obtained in high yields with the generation of gaseous HCl and CO<sub>2</sub> as byproducts to allow their isolations as crystalline solid products amenable to analysis by X-ray crystallography. With the advantage of using CHCl<sub>3</sub>, which bifunctionally serves as a reactant and a solvent, this photo-on-demand VR synthesis is available for one-pot syntheses of aldehydes, acid chlorides, formates, ketones, esters, and amides.
Polymorphisms in KCNE1 or KCNE3 are not associated with Ménière disease in the Caucasian population (2009)

Ménière disease (MD) is a complex disorder of unknown etiology characterized by the symptom triad of vertigo, sensorineural hearing loss, and tinnitus. Its reported incidence is 1-2 per 1,000 in Caucasians and 0.03-0.37 per 1,000 in Japanese. Doi et al. [Doi et al. (2005); ORL J Otorhinolaryngol Relat Spec 67:289-293] recently reported that two single nucleotide polymorphisms (SNPs) in KCNE1 and KCNE3 are associated with MD in Japanese subjects. Consistent with this possibility, these two genes encode potassium channels that are expressed in the stria vascularis and endolymphatic sac, respectively, and their role in ion transport suggests that they may be important in inner ear homeostasis. To establish whether a similar association exists in the Caucasian MD population, we sequenced the coding regions and exon-intron boundaries of both genes in 180 Caucasian persons with MD and 180 matched Caucasian controls. Neither of the two reported SNPs was significantly associated with MD when compared to the Caucasian controls (KCNE1, P = 0.55; KCNE3, P = 0.870). Comparison of allele frequencies between the Japanese MD population and our study population revealed no significant difference between groups (KCNE1, P = 0.90; KCNE3, P = 0.862), suggesting that the significant differences reported in the Japanese study arose from their control population. Six additional SNPs in both KCNE1 and KCNE3 were genotyped and none was associated with MD. Population stratification within our MD and Caucasian control population was excluded. Our data show that SNPs in KCNE1 and KCNE3 are not associated with MD in Caucasians.
ChemInform Abstract: Nucleophilic Ring‐Opening of N‐Benzylquinuclidinium Bromide. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Phase-cohering holography for fiber tapped-delay lines (2004)

We propose, analyze, and demonstrate the use of a holographic method for cohering the output of a fiber tapped-delay-line (FTDL). We perform a theoretical examination of the phase-cohering process and show experimental results for an RF spectrum analyzer based on a phase-cohered FTDL that shows 50 MHz resolution and bandwidths in excess of 2 GHz. Phase-cohering holography can operate on thousands of fibers in parallel, enabling both fiber tapped-delay-lines and the coherent fiber remoting of optically-modulated RF signals from antenna arrays.
Non-perturbative gauge transformations of arbitrary fermion correlation\n functions in quantum electrodynamics (2020)

We study the transformation of the dressed electron propagator and the\ngeneral $N$-point functions under a change in the covariant gauge of internal\nphoton propagators. We re-establish the well known Landau-Khalatnikov-Fradkin\ntransformation for the propagator and generalise it to arbitrary correlation\nfunctions in configuration space, finding that it coincides with the analogous\nresult for scalar fields. We comment on the consequences for perturbative\napplication in momentum-space.\n
Through-the-wall sensor systems based on hard x-ray imaging optics (2007)

This paper discusses a new approach to X-ray non-intrusive (NDE) inspection based on hard X-ray imaging optics. A new X-ray lens, called lobster-eye-lens (LEL) is the transmission lens, based on reflection optics, with grazing-angle deflection of 0.2° and photon energy of 40-100 keV. The lens reflection-optics is based on large, high-quality X-ray mirrors with r.m.s. lower than 1 nm. The through-the-wall inspection capability of such a system, based on Compton back-scattering, can be applied for longer ranges, (up to 100 m in the air), and thick walls (over 2 cm for wood, and over 2 mm for metal). CONOPS examples are given for homeland security applications.
Structural factors to improve physico-chemical properties of zwitterions as ion conductive matrices (2006)

Thermal properties and ion conductive characteristics of equimolar mixtures of zwitterion and lithium salts (Z/L mixtures) have been investigated. Through a systematic study of their structure–property relationship, we describe a zwitterion structure that produces high ionic conductivity when the zwitterion is mixed with lithium salt. We found that a pure zwitterion containing imide anion melted at 87 °C and the melting point of pure zwitterions was lowered in proportion to the alkyl spacer chain length between the anion and cation sites. In Z/L mixtures, ionic liquid-like domain formed between the cation sites of zwitterions and the anions of lithium salts regardless of the anion structure of the zwitterions. However, the anion structure affected the transference number of the lithium cation in the Z/L mixtures. To improve the thermal stability and the ionic conductivity of Z/L mixtures, suitable alkyl chain length between the cation and anion sites was determined to be 5 to 7 CH2 units.
Dynamic Bonding Mechanism of Ultrasonic Flip-Chip Microbump Bonding (2003)

This paper describes a new evaluation method for the dynamic bonding behavior of the microbump Ultrasonic Flip-chip Bonding (UFB). In order to elucidate the dynamic ultrasonic bonding mechanism on LISI packaging process with a microbump interconnection, we measured the ultrasonic amplitude of the chip and the substrate simultaneously during the bonding process. Consequently, the relative amplitude between the chip and the substrate was about 0.1μm, and this was considerably small compared with an amplitude of 3μm of the bonding tool. Then, we performed both a finite element analysis and a theoretical analysis based on the result of this relative amplitude, and examined a mechanical influence on the chip. As a result, it was shown that a desirable interconnection was enabled without the bonding damage to the chip in not only the Chip-on-Chip (COC) structure but also the multi-stacked LSI structure utilizing an ultrasonic bonding process.