gebhart/patrepeval huggingface dataset:
Modeling Transfer Matrices of Premixed Flames and Comparison with Experimental Results (1999)

A combined analytical/experimental investigation of the thermoacoustic properties of a gas turbine burner with a premixed, turbulent, swirl-stabilized flame is presented. In an enclosed flame, an interaction occurs between acoustic fluctuations and non-steady heat release, which may lead to thermoacoustic instabilities. This interaction may be characterized by the transfer matrix of the burner with flame. The transfer matrix describes the coupling between fluctuations of acoustic pressure and velocity on both sides of burner and flame, incorporating also the effects of heat release fluctuations on the acoustic quantities. The transfer matrix has been modeled and validated with experimental results. For the burner, an analytical model is proposed, which is based on the Bernoulli equation for instationary flow through compact elements. The model is based on the Rankine-Hugoniot relations across a thin heat source. The fundamental assumption underlying the model is that acoustic fluctuations cause modulations of fuel concentrations at the fuel injector, which result, after a certain time lag, in a fluctuating heat release rate at the flame. The oscillating heat release couples with pressure and velocity fluctuations in the combustion chamber, thereby creating a feedback loop between combustor acoustics and flame dynamics which may result in self-excited combustion instability.The transfer matrix of the burner with flame has been determined experimentally in an atmospheric combustion test facility. The test rig was equipped with loudspeakers and microphones in order to measure the response to an acoustical excitation. Our new flame model shows to be in agreement with the measured results.Copyright © 1999 by ASME
Supplementary Table 7 from Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors (2023)

&lt;p&gt;Supplementary Table 7: The effect of autosomal mosaic chromosomal alterations on death of cardiovascular disease causes, coronary artery disease causes, from cancer and any cause of death&lt;/p&gt;
Phenotyping of rare circulating cells in the blood of non-metastatic breast cancer patients using microfluidic Labyrinth technology (2022)

Label-free technologies for isolating rare circulating cells in breast cancer patients are widely available; however, they are mostly validated on metastatic patient blood samples. Given the need to use blood-based biomarkers to inform on disease progression and treatment decisions, it is important to validate these technologies in non-metastatic patient blood samples. In this study, we specifically focus on a recently established label-free microfluidic technology Labyrinth and assess its capabilities to phenotype a variety of rare circulating tumor cells indicative of epithelial-to-mesenchymal transition as well as cancer-associated macrophage-like (CAML) cells. We specifically chose a patient cohort that is non-metastatic and selected to undergo neoadjuvant chemotherapy to assess the performance of the Labyrinth technology. We enrolled 21 treatment naïve non-metastatic breast cancer patients of various disease stages. Our results indicate that (i) Labyrinth microfluidic technology is successfully able to isolate different phenotypes of CTCs despite the counts being low. (ii) Invasive phenotypes of CTCs such as transitioning CTCs and mesenchymal CTCs were found to be present in high numbers in stage III patients as compared to stage II patients. (iii) As the total load of CTCs increased, the mesenchymal CTCs were found to be increasing. (iv) Labyrinth was able to isolate CAMLs with the counts being higher in stage III patients as compared to stage II patients. Our study demonstrates the ability of the Labyrinth microfluidic technology to isolate rare cancer-associated cells from the blood of treatment naïve non-metastatic breast cancer patients, laying the foundation for tracking oncogenic spread and immune response in patients undergoing neoadjuvant chemotherapy.
Microarray analysis of Streptococcus pneumoniae gene expression changes to human lung epithelial cells (2008)

Streptococcus pneumoniae infection starts from the respiratory tract where interaction with host epithelial cells occurs. To gain more insights on pneumococcal pathogenesis, an oligonucleotide (oligo)-based microarray was used to investigate gene expression changes of one serotype 3 encapsulated pathogenic S. pneumoniae strain 82 and one unencapsulated avirulent S. pneumoniae strain R6 upon exposure to human lung epithelial cells (A549) for 1 and 3 h, respectively. We observed that genes associated with many functional categories were differentially regulated in strain 82, such as genes in pathogenesis, cell envelope, transcription, translation, transport, metabolism, and unknown functions. In contrast, few genes were changed in strain R6 except for genes in ribonucleotide biosynthesis and unknown functions. Quantitative real-time PCR analysis confirmed the microarray results for most of the genes tested. To further characterize functions of the selected genes, knockout mutants were constructed in strain R6. We demonstrated that 2 genetic loci, SP_2170 (AdcB, zinc ABC transporter) and SP_0157 (hypothetical protein), were involved in adherence to A549 cells. These data suggest that divergent gene expression changes occur in S. pneumoniae pathogenic and avirulent strains during interaction with human lung epithelial cells. Some of those genes are involved in pneumococcal pathogenesis.
3.3kV SiC MOSFETs designed for low on-resistance and fast switching (2012)

This paper discusses the latest developments in the optimization and fabrication of 3.3kV SiC vertical DMOSFETs. The devices show superior on-state and switching losses compared to the even the latest generation of 3.3kV fast Si IGBTs and promise to extend the upper switching frequency of high-voltage power conversion systems beyond several tens of kHz without the need to increase part count with 3-level converter stacks of faster 1.7kV IGBTs.
Thrombin-Anti-Thrombin Levels and Patency of Arterio-Venous Fistula in Patients Undergoing Haemodialysis Compared to Healthy Volunteers: A Prospective Analysis (2013)

The novel finding of this study is that in patients on haemodialysis, TAT levels were increased and inversely correlated with primary assisted patency and secondary patency. Further evaluation is required into the possible role of TAT as a biomarker of AVF occlusion.
Carbon Nanotube Multilayer Nanocoatings Prevent Flame Spread on Flexible Polyurethane Foam (2015)

In an effort to protect polyurethane foam (commonly used as cushioning in upholstered furniture) from fire using environmentally benign chemistries, nanocomposite thin films are deposited using water‐based solutions of cationic‐ and anionic‐stabilized multiwalled carbon nanotubes (MWCNTs). The open‐celled foam is coated using layer‐by‐layer (LbL) assembly to produce uniform protective layers up to 600 nm thick, comprised of cationic polyethylenimine modified with pyrene (PEI‐Py), anionic poly(acrylic acid) (PAA), and MWCNT. Film thickness is found to rely heavily on the PAA‐stabilized MWCNT solution. Coatings of only six [PEI‐Py/PAA+MWCNT] bilayers (BL) show tremendous reductions in peak heat release rate (up to 67%) and total smoke release (up to 80%) for the polyurethane foam. This same coating significantly improves the performance of the polyurethane when exposed to horizontal and vertical flame tests. With 9 BL, the foam successfully withstands a vertical burn test, self‐extinguishing immediately after removal of the test flame. These dramatic reductions in foam flammability are unprecedented and are attributed to the protective nature of the carbon‐based char formed from the coating that acts as a protective barrier. image
The nature of the n .fwdarw. 3p transition in 1,4-diazabicyclo[2.2.2]octane: a magnetic circular dichroism study (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe nature of the n .fwdarw. 3p transition in 1,4-diazabicyclo[2.2.2]octane: a magnetic circular dichroism studyShlomo Habousha and Aharon GedankenCite this: J. Phys. Chem. 1982, 86, 20, 3920–3921Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September 1982https://pubs.acs.org/doi/10.1021/j100217a007https://doi.org/10.1021/j100217a007research-articleACS PublicationsRequest reuse permissionsArticle Views29Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Blue copper proteins: Synthesis, spectra, and structures of Cu I N 3 (SR) and Cu II N 3 (SR) active site analogues (1977)

The reaction of Cu(SR) or [Cu(SR)][ClO(4)] derivatives (SR = p-nitrobenzenethiolate or O-ethylcysteinate) with potassium hydrotris(3,5-dimethyl-1-pyrazolyl)borate produces redox pairs of the stoichiometry Cu(I)N(3)(SR) and Cu(II)N(3)(SR). These complexes are well-defined synthetic approximations to the proposed N(3)S binding sites of blue (type 1) copper electron transfer proteins. The compounds were investigated by a variety of chemical and spectral (optical, resonance Raman, and electron paramagnetic resonance) techniques; the complex K[Cu(hydrotris(3,5-dimethyl-1-pyrazolyl)borate)(p- NO(2)C(6)H(4)S]-2 acetone was also studied by single-crystal x-ray diffraction methods. The spectrochemical characteristics of the Cu(II)N(3)(SR) species are in large part similar to the native system and thus provide some perspective regarding the origin of the unique type 1 spectral parameters and electron transfer properties.
Simulation of bit error performance and outage probability of pi /4 DQPSK in frequency-selective indoor radio channels using a measurement-based channel model (2003)

A real-time simulation tool called BERSIM is developed and used to study bit-by-bit errors, average bit error rate and block outage probabilities for pi /4 differential quadrature phase-shift keying (DQPSK) at megabit rates with raised-cosine pulse shaping. Simulation results show that when the ratio of RMS delay spread to bit duration is greater than about 0.02, the irreducible average BER is not only a function of RMS delay spread, but is also a function of the temporal and spatial distribution of individual multipath components in the complex channel impulse response. The results show that fading caused by multipath cancellation is the major error mechanism over a local area for RMS delay spreads smaller than 0.02-b duration. An example of BERSIM's real time output is shown for the transmission of a video image through a mobile radio system. The simulation methods are suited for evaluation and design of indoor wireless LANs, as well as paging and cellular systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Identification of candidate mitochondrial inheritance determinants using the mammalian cell-free system (2023)

The degradation of sperm-borne mitochondria after fertilization is a conserved event. This process known as post-fertilization sperm mitophagy, ensures exclusively maternal inheritance of the mitochondria-harbored mitochondrial DNA genome. This mitochondrial degradation is in part carried out by the ubiquitin-proteasome system. In mammals, ubiquitin-binding pro-autophagic receptors such as SQSTM1 and GABARAP have also been shown to contribute to sperm mitophagy. These systems work in concert to ensure the timely degradation of the sperm-borne mitochondria after fertilization. We hypothesize that other receptors, cofactors, and substrates are involved in post-fertilization mitophagy. Mass spectrometry was used in conjunction with a porcine cell-free system to identify other autophagic cofactors involved in post-fertilization sperm mitophagy. This porcine cell-free system is able to recapitulate early fertilization proteomic interactions. Altogether, 185 proteins were identified as statistically different between control and cell-free-treated spermatozoa. Six of these proteins were further investigated, including MVP, PSMG2, PSMA3, FUNDC2, SAMM50, and BAG5. These proteins were phenotyped using porcine in vitro fertilization, cell imaging, proteomics, and the porcine cell-free system. The present data confirms the involvement of known mitophagy determinants in the regulation of mitochondrial inheritance and provides a master list of candidate mitophagy co-factors to validate in the future hypothesis-driven studies.
Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week Protocol (2021)

The COVID-19 pandemic caused by the SARS-CoV-2 coronavirus requires reliable assays for studying viral entry mechanisms which remains poorly understood. This knowledge is important for the development of therapeutic approaches to control SARS-CoV-2 infection by permitting the screening for neutralizing antibodies and other agents that can block infection. This is particularly important for patients who are at high risk for severe outcomes related to COVID-19. The production of pseudotyped viral particles may seem like a daunting task for a non-virology laboratory without experience in the two most commonly used pseudotyping systems, namely retro/lentiviruses and vesicular stomatitis virus (VSV) which lacks the VSV envelope glycoprotein (VSVΔG). By incorporating the most up-to-date knowledge, we have developed a detailed, easy-to-follow novel protocol for producing SARS-CoV-2 spike-bearing pseudovirus using the VSV-ΔG system. We describe the infection assay which uses GFP fluorescence as a measure of infection in a 24-well live imaging system. We present results of our optimization of the system to enhance viral infection levels through the over-expression of human ACE2 receptor and the overexpression of at least one of two proteases - TMPRSS2 or Furin, as well as, supplementation with Poloxamer 407 (P407) and Prostaglandin E2 (PGE2) as adjuvants. We show that the system works efficiently in three unrelated, clinically relevant cell lines: human 293T (renal epithelial) cells, human Calu-3 (lung epithelial) cells, and the non-human primate (African Green Monkey) cell line, Vero-E6 (renal epithelial) cells. In addition, we have used this system to show infection of human induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs). This system is efficient (virus generation, titration, and infection assays can be performed in 1 week), quantitative, inexpensive, and readily scalable for application in drug development and therapeutic screening approaches.
Usability and Acceptability Studies of Conversational Virtual Human Technology. (2004)

Acceptance, accessibility, and usability data from a series of studies of a series of applica-tions suggest that most users readily accept re-sponsive virtual characters as valid conversational partners. By responsive virtual characters we mean full-body animated, con-versant, realistic characters with whom the user interacts via natural language and who exhibit emotional, social, gestural, and cogni-tive intelligence. We have developed applica-tions for medical clinicians interviewing pediatric patients, field interviewers learning about in-formed consent procedures, and tele-phone interviewers seeking to obtain coopera-tion from respondents on federally-funded surveys. Usage data from informational kiosks using the same underlying technology (e.g., at conference exhibits) provide additional cor-roboration. Our evidence suggests the tech-nology is both sufficient to actively engage users and appropriate for consideration of use in training, assessment, and marketing envi-ronments. 1
A high-speed silicon FET for efficient DC-DC power conversion (2012)

A novel silicon device architecture for DC-DC power conversion is reported. Efficient switching at high frequencies (1-5 MHz) is achieved by simultaneously reducing gate charge, reverse capacitance, and gate resistance while still maintaining good on-state resistance and off-state breakdown voltage. Power efficiencies in excess of 88% were realized in a synchronous buck converter running at 1.3 MHz.
Follow‐up (2008)

This chapter contains sections titled: Requirements for a device follow-up clinic Pacemaker follow-up Pacemaker clinic follow-up visit Implantable cardioverter-defibrillator follow-up Patient-specific programming and therapy Conclusion References
Supplemental Figures and Legends from Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors (2023)

&lt;p&gt;Supplemental Figures S1-S6 and Legends&lt;/p&gt;
High-Resolution Millimeter-Wave Tomography System for Characterization of Low-Permittivity Materials (2020)

Tomographic microwave imaging is employed in numerous industrial applications, e.g., nondestructive testing. However, most existing systems are not suitable for measurements of low-permittivity materials such as gaseous substances or insulating foam with high air content. This paper introduces a 79 GHz high-resolution tomography system enabling characterization of materials with relative permittivity close to one. It is based on fully-integrated frequency-modulated continuous-wave radar transceivers which significantly reduce cost and complexity. A first prototype is built with two radar sensors and a rotary stage to emulate a higher sensor count. The medium-dependent time-of-flight through the area-under-test is evaluated and Tikhonov regularization is applied to solve the inverse problem and reconstruct a 2D image. System simulations and measurements with low-permittivity foam objects confirm the feasibility of this approach.
Dynamic control of endogenous metabolism with combinatorial logic circuits (2018)

Controlling gene expression during a bioprocess enables real-time metabolic control, coordinated cellular responses, and staging order-of-operations. Achieving this with small molecule inducers is impractical at scale and dynamic circuits are difficult to design. Here, we show that the same set of sensors can be integrated by different combinatorial logic circuits to vary when genes are turned on and off during growth. Three <i>Escherichia coli</i> sensors that respond to the consumption of feedstock (glucose), dissolved oxygen, and by-product accumulation (acetate) are constructed and optimized. By integrating these sensors, logic circuits implement temporal control over an 18-h period. The circuit outputs are used to regulate endogenous enzymes at the transcriptional and post-translational level using CRISPRi and targeted proteolysis, respectively. As a demonstration, two circuits are designed to control acetate production by matching their dynamics to when endogenous genes are expressed (<i>pta</i> or <i>poxB</i>) and respond by turning off the corresponding gene. This work demonstrates how simple circuits can be implemented to enable customizable dynamic gene regulation.
Fc and C3 Receptors Induced by Herpes Simplex Virus on Cultured Human Endothelial Cells (1982)

The mechanism by which immune complexes deposit in vascular tissue is uncertain. Several human viruses, including herpes simplex virus, have recently been demonstrated to replicate in human endothelial cells. Such viruses may injure vascular tissue and could play a role in the pathogenesis of immune complex deposition. Therefore, we studied the expression of receptors for immune complexes containing IgG and C3 on endothelial cells after infection with herpes simplex virus type I.Human umbilical vein endothelial cells were incubated with (51)Cr-labeled sheep erythrocytes sensitized with IgG, IgM, or IgM plus complement. Preferential binding of IgG or complement-coated erythrocytes to uninfected endothelial monolayers was not observed. In contrast, significant binding of erythrocytes coated with IgG or IgM plus complement was observed after viral infection. Phase-contrast and scanning electron microscopy demonstrated erythrocyte adherence around the infected endothelial cells in a rosette pattern. Binding of IgG-coated erythrocytes was fully inhibited by Fc (0.31 mg/ml) but not Fab' fragments of nonimmune IgG. Binding of complement-coated cells was unaffected by the presence of IgG (1 mg/ml). With purified individual components, binding of complement-coated erythrocytes depended on the presence and was proportional to the concentration of C3. Binding of IgG-or C3-coated cells was detected beginning 4 h after infection. These studies indicate that herpes simplex virus type I infection can induce IgG and C3 receptors on human endothelial cells. These receptors may promote the deposition of immune complexes in vascular tissue after certain viral infections.
Impact of growth parameters on the background doping of GaN films grown by ammonia and plasma-assisted molecular beam epitaxy for high-voltage vertical power switches (2021)

We report on ammonia and plasma-assisted molecular beam epitaxy (NH3-MBE and PAMBE) grown GaN layers with a low net carrier concentration (Nnet). Growth parameters, such as growth rate, V–III ratio, and plasma power, were investigated on different substrates to study their impact on surface morphology and background doping levels using atomic force microscopy and capacitance–voltage (C–V) measurements, respectively. The elevated growth rates are especially interesting for vertical power switches, requiring very thick drift regions (over 10 μm) with low background concentrations. For our NH3-MBE-grown layers, Nnet shows an almost linear increase with the growth rate. Using a freestanding substrate and at a fast growth rate of 1.4 μm hr−1, a Nnet value as low as 1 × 1015 cm−3 was achieved. For samples grown via PAMBE, the lowest Nnet among samples grown under a Ga adlayer was 2 × 1016 cm−3 for a growth rate of 0.32 μm h−1 on a GaN-on-sapphire template. The results support the use of MBE for growing high-quality GaN material with reasonably fast growth rates maintaining low background doping levels for high-voltage vertical power electronic devices.
<title>Standardization of broadband radio access networks</title> (1998)

This paper introduces the ETSI Project on Broadband Radio Access Networks (EP-BRAN). BRAN systems will be used for local area applications with limited mobility (HIPERLAN/2); fixed access with area coverage in urban and rural areas (HIPERACCESS); and short range high-speed point-to-point links (HIPERLINK). They will support transport of either IP or ATM protocols, supporting managed quality of service. Such systems are needed to provide access to the future broadband core networks supporting multi-media applications. The paper addresses the motivation and market demand for broadband radio access networks, the objectives and scope of the Project, the operational and technical requirements, the types of networks to be standardized, the scope of the standards, the issue of spectrum and the Project schedule.