gebhart/patrepeval huggingface dataset:
Seizure detection methods using a cascade architecture for real-time implantable devices (2013)

Implantable high-accuracy, and low-power seizure detection is a challenge. In this paper, we propose a cascade architecture to combine different seizure detection algorithms to optimize power and accuracy of the overall seizure detection system. The proposed architecture consists of a cascade of two seizure detection stages. In the first-stage detector, a lightweight (low-power) algorithm is used to detect seizure candidates with the understanding that there will be a high number of false positives. In the second-stage detector-and only for the seizure candidates detected in the first detector-a high-accuracy algorithm is used to eliminate the false positives. We show that the proposed cascade architecture can reduce power consumption of seizure detection by 80% with high accuracy, offering a suitable option for real-time implantable seizure detectors.
PINTANDO O SETE... SE FECHAR VIRA HOSPÍCIO, SE ABRIR VIRA CIRCO, GRAFFITE E BREAK! E VIRA VIDA! (2017)

versus as novas propostas de cuidados em sade mental a partir da Reforma Psiquitrica, que prev um tratamento mais
Epithelial mucin-1 (MUC1) expression and MA5 anti-MUC1 monoclonal antibody targeting in multiple myeloma. (1999)

Multiple myeloma (MM) is the second most common hematological cancer in the United States. It is typically incurable, even with myeloablative chemotherapy and stem-cell transplantation. The epithelial mucin-1 (MUC1) glycoprotein is expressed by normal and malignant epithelial cells but has also been shown to be expressed by MM cells. MUC1 is a useful antigenic target in solid tumors for clinical diagnostic and therapeutic monoclonal antibody (mAb)-based approaches. The MA5 mAb, as well as other anti-MUC1 mAbs reactive with the MUC1 variable number tandem repeat domain, exhibited moderate to strong reactivity with both MM cell lines and clinical samples. To explore the biochemical nature and potential of MUC1 as an antigenic target in MM, studies were performed to: (a) compare the mRNA and the MUC1 glycoprotein species between epithelial cancer and MM cell lines; and (b) develop and use a human MM tumor xenograft model system to study the biodistribution of the MA5 mAb. MA5 mAb was strongly reactive with six of eight human MM cell lines by flow cytometry. In seven of eight MM patient samples (bone marrow and/or peripheral blood) reactivity was found in 10-90% of the cells, whereas normal control (n = 5) and leukemia and lymphoma (n = 5) cells showed only 0-6% reactivity. 125I-labeled MA5 whole-cell binding studies showed quantitatively similar amounts of binding between strongly positive MM lines and high-MUC1-expressing breast carcinoma lines. mRNA expression was assessed by Northern blotting and reverse transcription-PCR. MM cell lines were positive by both methods, with strong similarity in the sizes of the mRNAs and cDNAs that were obtained. Finally, biodistribution experiments were carried out with 131I-labeled MA5 versus a nonbinding control 125I-labeled mAb in a s.c. MM xenograft model. Selective MM tumor uptake of the MA5 mAb was demonstrated, with a potential for delivering a tumor radiation absorbed dose of 8540 cGy/mCi of injected dose compared with 3099 cGy/mCi of tumor-absorbed dose delivered by nonspecific antibody.
A quantitative study of the flexibility contributed to RNA structures by nicks and single-stranded gaps (1998)

Disulfide crosslinking via thiol-disulfide interchange was applied to quantitate the relative flexibility contributed by nicks and single-stranded gaps in an RNA structure. An RNA duplex comprised of three strands was constructed containing the disulfide crosslink precursors 1 and 2 at opposite ends of the duplex on opposite strands. The third strand was of varying length to yield a nick or single-stranded gaps of 1, 2, or 3 nt. Crosslinking rates Indicated relative flexibilities of the resulting two-helix junctions. Crosslinking in the nicked duplex occurred two orders of magnitude slower than in a duplex containing a 3-nt gap. Rates of crosslinking in duplexes with 3-and 2-nt gaps showed only modest dependence on the gap sequence. Many natural RNAs, including ribozymes, contain two-helix junctions related to the model system described here. The data suggest that two-helix junctions containing a nick in one strand will retain substantial rigidity, whereas one or more single-stranded nucleotides at a two-helix junction allow significant flexibility.
On traffic locality and QoE in hybrid CDN-P2P networks (2011)

Hybrid CDN-P2P applications, such as P2P applications, tend to sometimes ignore traffic costs at ISPs and generate large amounts of undesirable cross-ISP traffic. As blocking the traffic does not seem to solve the problem, some simple cooperation between the neighboring peers will be beneficial. In this case, some biased neighbor selection helps peers connecting to others within the same Autonomous System, hence keeping communication local. We developed a detailed simulation model to evaluate the problem and discovered that using a biased neighborhood selection in a hybrid CDN-P2P content network can even enhance user's quality of experience (QoE) and fundamentally reduce the cross-ISP traffic even with the presence of a transit ISP making de-localization decisions.
Digitally controlled low-harmonic rectifier having fast dynamic responses (2003)

This paper describes a completely digitally controlled low-harmonic rectifier. It is shown that the dynamics of the outer voltage loop can be significantly improved using a digital notch filter. Low input current harmonics and fast voltage response are experimentally verified using a 200 W universal-input boost power supply operating at the switching frequency of 200 kHz.
Aldol condensation reactions of acetone over alkali-modified vanadium phosphate catalysts (2002)

The acid–base properties of vanadium phosphate catalysts are investigated using the aldol condensation of acetone and the reactions of 2-methylbut-3-yn-2-ol (MBOH) over alkali-doped vanadium phosphate catalysts. Two well defined vanadium phosphates were investigated, namely (VO)2P2O7 and δ-VOPO4. Alkali-doped (VO)2P2O7 was prepared by heating alkali-doped VOHPO4·0.5H2O in He (8 h, 750 °C), and Na+-, K+- and Cs+-doped samples were investigated. The reaction of MBOH was used to probe the acid–base nature of the surface sites. The undoped V4+ (VO)2P2O7 exhibited only acidic active sites, whereas when doped with 10% Na+, K+ or Cs+ the active sites became predominantly basic in nature. Both the doped and undoped samples were selective for the formation of isophorone (selectivity 90%) from the aldol condensation of acetone, and the Cs-doped and undoped (VO)2P2O7 exhibited similar intrinsic activities (mol(isophorone) m−2 h−1). In contrast, alkali-doping of the V5+ vanadium phosphate γ-VOPO4 did not induce the formation of a significant number of surface basic sites and the active sites for MBOH decomposition remained predominantly acidic in nature. Both the doped and undoped δ-VOPO4 were non-selective in the aldol condensation of acetone, and during the short-lived reaction, only hydrocarbons (typically isobutane and isobutene) were observed. The results are discussed with respect to the nature of active sites for the selective oxidation of n-butane to maleic anhydride.
ChemInform Abstract: Li Metal‐Free Rechargeable LiMn2O4/Carbon Cells: Their Understanding and Optimization. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Interaction of Polarized near-UV Light with Si Nanostructures: Raman Imaging and Stress Study (2011)

A record high Si structure Raman efficiency is obtained in near UV for ~10 nm wide Si nanowires. Using high-numerical-aperture lens, we observed Raman-forbidden phonons of strained-Si nanowires/islands and measured stress relaxation.
Mimesis of dehydrogenase catalyzed reductions with chiral, bridged 1,4-dihydropyridines (1979)

Het in dit proefschrift beschreven onderzoek was oorspronkelijk gericht op de volgende twee doeleinden: i. Het vinden van een bredere toepassing van 1,4-dihydropyridines die als modellen voor NADH beschouwd kunnen worden - als reductor in de organische synthese. ii. Het ontwikkelen van een reactiesysteem waarbij de (dure) dihydropyridines m.b.v. een secundaire reduktor continu geregenereerd worden. Hierdoor zou het mogelijk worden reducties uit te voeren met slechts een catalytische hoeveelheid dihydropyridine. ... Zie: Samenvatting
Amine-buffered Phase Separating Tetraethoxysilane–Water Binary Mixture: A Simple Precursor of Sol–Gel Derived Monolithic Silica Gels and Glasses (2010)

Abstract Amines are used as pH control agents to form macroporous silica gels utilizing macroscopic phase separation of acid-catalyzed tetraethoxysilane–water binary mixture. The wide pKa variety of amines from basic to acidic regions is suitable to buffer the solution at neutral pH range, at which the phase separation becomes prominent. This method allows monolithic silica gels and glasses to be prepared reproducibly from alkoxide-based solutions with minimal use of pH control agents.
Avaliações heurísticas para decisões de acessibilidade: uma revisão sistemática da literatura (2023)

Há cada vez mais pessoas que usam a tecnologia diariamente para se comunicar e acessar informações, incluindo idosos e pessoas com deficiência. As tecnologias assistivas, também chamadas de auxílios técnicos, são recursos de acessibilidade e inclusão que proporcionam maior grau de autonomia e assistência para pessoas que apresentam algum grau de dificuldade na utilização de recursos em seu contato com ambientes reais e virtuais. O objetivo deste estudo é investigar as percepções sobre a avaliação heurística de acessibilidade em software por meio de uma revisão sistemática da literatura que abrange os últimos 5 anos. Isso começou com um total de 8.548 artigos publicados indexados nas bases de dados Scopus e Web of Science. Foram elaboradas doze questões de pesquisa relevantes que foram respondidas de acordo com os resultados encontrados no conjunto final de artigos. Dois grupos de palavras-chave foram criados para auxiliar na busca de artigos e um processo de filtragem foi aplicado aos resultados das buscas. A pesquisa mostra, por meio de figuras e tabelas, evidências sobre o crescimento da produção científica na área. Os principais autores e periódicos que publicam sobre avaliação da acessibilidade de software são listados, assim como as respostas às perguntas sobre quais modelos avaliativos, heurísticas, métricas, limitações, tecnologias assistivas e públicos-alvo são mais citados nos artigos publicados. Este estudo também analisa a cocitação das referências e fontes bibliográficas casadas. A pesquisa mostrou evidências de que não há um consenso geral sobre o uso de um único modelo para avaliar a acessibilidade, mas que as diretrizes W3C WCAG são as fontes mais utilizadas para referenciar heurísticas e métricas em estudos desse tipo. Percebeu-se também que a maioria dos estudos não foca em tecnologias assistivas, mas são amplamente utilizadas para apoiar decisões em websites.
Memory buddies (2009)

Many data center virtualization solutions, such as VMware ESX, employ content-based page sharing to consolidate the resources of multiple servers. Page sharing identifies virtual machine memory pages with identical content and consolidates them into a single shared page. This technique, implemented at the host level, applies only between VMs placed on a given physical host. In a multi-server data center, opportunities for sharing may be lost because the VMs holding identical pages are resident on different hosts. In order to obtain the full benefit of content-based page sharing it is necessary to place virtual machines such that VMs with similar memory content are located on the same hosts.
Aircraft-Based Estimate of Total Methane Emissions from the Barnett Shale Region (2015)

We present estimates of regional methane (CH4) emissions from oil and natural gas operations in the Barnett Shale, Texas, using airborne atmospheric measurements. Using a mass balance approach on eight different flight days in March and October 2013, the total CH4 emissions for the region are estimated to be 76 ± 13 × 10(3) kg hr(-1) (equivalent to 0.66 ± 0.11 Tg CH4 yr(-1); 95% confidence interval (CI)). We estimate that 60 ± 11 × 10(3) kg CH4 hr(-1) (95% CI) are emitted by natural gas and oil operations, including production, processing, and distribution in the urban areas of Dallas and Fort Worth. This estimate agrees with the U.S. Environmental Protection Agency (EPA) estimate for nationwide CH4 emissions from the natural gas sector when scaled by natural gas production, but it is higher than emissions reported by the EDGAR inventory or by industry to EPA's Greenhouse Gas Reporting Program. This study is the first to show consistency between mass balance results on so many different days and in two different seasons, enabling better quantification of the related uncertainty. The Barnett is one of the largest production basins in the United States, with 8% of total U.S. natural gas production, and thus, our results represent a crucial step toward determining the greenhouse gas footprint of U.S. onshore natural gas production.
Active Detection of Shielded SNM With 60-keV Neutrons (2009)

Fissile materials, e.g., <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">235</sup> U and <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">239</sup> Pu, can be detected non-invasively by active neutron interrogation. A unique characteristic of fissile material exposed to neutrons is the prompt emission of high-energy (E > 1 MeV) fission neutrons. One promising mode of operation subjects the object to a beam of low-energy (E < 1 MeV) neutrons, generated by a proton beam impinging on a Li target. The emergence of high-energy secondary neutrons then clearly indicates the presence of fissile material. Our interrogation system comprises a low-dose 60-keV neutron generator (5 times 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> /s ), and a 1 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> array of scintillators for high-energy neutron detection. Preliminary experimental results demonstrate the detectability of small quantities (376 g) of <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">235</sup> U shielded by steel (200 g/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) or plywood (30 g/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ), with a typical measurement time of 1 min.
Slow-Time MIMO-FMCW Automotive Radar Detection with Imperfect Waveform Separation (2020)

This paper considers object detection in the case of imperfect waveform separation, in the context of automotive radars with a slow-time MIMO-FMCW signaling scheme. We develop an explicit signal model that accounts for waveform separation residuals and propose a Kronecker subspace-based object detector in the framework of generalized likelihood ratio test (GLRT). Our exact theoretical analysis under both hypotheses shows that the proposed detector holds the desired property of constant false alarm rate (CFAR). Numerical simulations validate our proposed object detection scheme.
Antimicrobial Polymers (2014)

Better health is basic requirement of human being, but the rapid growth of harmful pathogens and their serious health effects pose a significant challenge to modern science. Infections by pathogenic microorganisms are of great concern in many fields such as medical devices, drugs, hospital surfaces/furniture, dental restoration, surgery equipment, health care products, and hygienic applications (e.g., water purification systems, textiles, food packaging and storage, major or domestic appliances etc.) Antimicrobial polymers are the materials having the capability to kill/inhibit the growth of microbes on their surface or surrounding environment. Recently, they gained considerable interest for both academic research and industry and were found to be better than their small molecular counterparts in terms of enhanced efficacy, reduced toxicity, minimized environmental problems, resistance, and prolonged lifetime. Hence, efforts have focused on the development of antimicrobial polymers with all desired characters for optimum activity. In this Review, an overview of different antimicrobial polymers, their mechanism of action, factors affecting antimicrobial activity, and application in various fields are given. Recent advances and the current clinical status of these polymers are also discussed.
Spectral tomographic imaging with aplanatic metalens (2019)

Tomography is an informative imaging modality that is usually implemented by mechanical scanning, owing to the limited depth-of-field (DOF) in conventional systems. However, recent imaging systems are working towards more compact and stable architectures; therefore, developing nonmotion tomography is highly desirable. Here, we propose a metalens-based spectral imaging system with an aplanatic GaN metalens (NA = 0.78), in which large chromatic dispersion is used to access spectral focus tuning and optical zooming in the visible spectrum. After the function of wavelength-switched tomography was confirmed on cascaded samples, this aplanatic metalens is utilized to image microscopic frog egg cells and shows excellent tomographic images with distinct DOF features of the cell membrane and nucleus. Our approach makes good use of the large diffractive dispersion of the metalens and develops a new imaging technique that advances recent informative optical devices.
Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis. (2001)

Dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) are recurrent, infiltrative skin tumors that presently are treated with surgery. DFSP and GCF tumors are genetically characterized by chromosomal rearrangements fusing the collagen type Ialpha1 (COLIA1) gene to the platelet-derived growth factor B-chain (PDGFB) gene. It has been shown that the resulting COL1A1/PDGF-B fusion protein is processed to mature PDGF-BB. Autocrine PDGF receptor stimulation has therefore been predicted to contribute to DFSP and GCF tumor development and growth. Here we demonstrate presence of activated PDGF receptors in primary cultures derived from six different DFSP and GCF tumors. Three of the primary cultures were further characterized; their in vitro growth displayed an increased sensitivity to treatment with the PDGF receptor tyrosine kinase inhibitor STI571, as compared with normal fibroblasts. Transplantable tumors, displaying a DFSP-like histology, were established from one of the DFSP primary cultures. Treatment of tumor-bearing severe combined immunodeficient mice with STI571 reduced tumor growth. The growth-inhibitory effects in vitro and in vivo occurred predominantly through induction of tumor cell apoptosis. Our study demonstrates growth-inhibitory effects of PDGF receptor antagonists on human DFSP- and GCF-derived tumor cells and demonstrates that autocrine PDGF receptor stimulation provides antiapoptotic signals contributing to the growth of these cells. These findings suggest targeting of PDGF receptors as a novel treatment strategy for DFSP and GCF.
Therapeutic approaches to activate the canonical Wnt pathway for bone regeneration (2022)

Activation of the canonical Wingless-related integration site (Wnt) pathway has been shown to increase bone formation and therefore has therapeutic potential for use in orthopedic conditions. However, attempts at developing an effective strategy to achieve Wnt activation has been met with several challenges. The inherent hydrophobicity of Wnt ligands makes isolating and purifying the protein difficult. To circumvent these challenges, many have sought to target extracellular inhibitors of the Wnt pathway, such as Wnt signaling pathway inhibitors Sclerostin and Dickkopf-1, or to use small molecules, ions and proteins to increase target Wnt genes. Here, we review systemic and localized bioactive approaches to enhance bone formation or improve bone repair through antibody-based therapeutics, synthetic Wnt surrogates and scaffold doping to target canonical Wnt. We conclude with a brief review of emerging technologies, such as mRNA therapy and Clustered Regularly Interspaced Short Palindromic Repeats technology, which serve as promising approaches for future clinical translation.
Characterization of modified polypropylene by scanning electron microscopy (2000)

Characterizing the morphology of modified multiphasic polymer systems, as are often applied for improving the impact strength, is normally a complicated and tedious task. Nevertheless, knowledge about the volume fraction and particle-size distribution of the elastomer phase is important for the specific development of high-impact systems. Direct production in the reactor enables only indirect control of these two quantities. Computer-controlled scanning electron microscopy in combination with image processing allows an automated measurement of both all the necessary particle parameters (size distribution, shape, orientation, etc.) and the elastomer content of the material. Since bulk materials are used for the investigation, additionally, three-dimensional information about the structure of the material can be gained by simply varying the electron energy, without the necessity to resort to multiple slices. This information is especially important in the case of particles with extremely irregular shapes, as obtained, for example, by strong agglomeration of the modifier particles. The mathematical routines used for calculation of the particle-size distributions from the measured profile-size distributions cannot be applied in such cases. The method was tested for several materials with significantly different compositions, both immediately after molding and also after a subsequent thermal relaxation. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 78: 1152–1161, 2000
A hierarchical porous ionic organic polymer as a new platform for heterogeneous phase transfer catalysis (2015)

A hierarchical porous ionic polymer with excellent amphiphilicity has been successfully constructed and demonstrates extraordinary performances as a heterogeneous phase transfer catalyst.
ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma (2021)

Increased ACE2 expression occurs in older people and males. Asthma patients have reduced expression. Altered ACE2 expression in the lower airway may be an important factor in virus tropism and may in part explain susceptibility factors and why asthma patients are not over-represented in those with COVID-19 complications.
Intermediate representations for controllers in chip generators (2011)

Creating parameterized “chip generators” has been proposed as one way to decrease chip NRE costs. While many approaches are available for creating or generating flexible data path elements, the design of flexible controllers is more problematic. The most common approach is to create a microcoded engine as the controller, which offers flexibility through programmable table-based lookup functions. This paper shows that after “programming” the hardware for the desired application, or applications, these flexible controller designs can be easily converted to efficient fixed (or less programmable) solutions using partial evaluation capabilities that are already present in most synthesis tools.