gebhart/patrepeval huggingface dataset:
Novel reconfigurable matching network for compact multi-band PA (2012)

This paper presents a new compact reconfigurable MN for a multi-band power amplifier (PA). In the new MN topology, one matching element (ME) is used to match two or more frequency bands by connecting two or more SPST SWs. For more than three frequency bands, the proposed MN uses fewer MEs than the reconfigurable MN in the previously reported Pas [3]-[5]. The new MN is designed and fabricated to cover the 1.5 GHz, 1.7 GHz, and 2.0 GHz frequency bands. The SW states, which obtain the best PA characteristics for each band, are chosen for the design of the proposed MN in the PA. The fabricated PA exhibits the reflection characteristics of below -10 dB and the gain of 8 dB. Since the proposed MN requires fewer MEs than other MNs, it can help miniaturize and drive down the cost of the reconfigurable PA.
Towards User-Centric Robot Furniture Arrangement (2021)

Imbuing furniture with robot properties reduces the physical labor and time needed for arranging spaces, such as homes, classrooms, and offices. Outsourcing labor tasks to robot furniture requires users’ involvement with functional user interfaces. We performed a user study on multi-robot furniture and added additional features based on the study results. The study involved 12 participants rearranging multiple non-robotic and robotic chairs (ChairBots). Results from the video and interview analysis revealed five high-level features missing in the original ChairBot: dual screen-based user interface, the ability to save and to set arrangements, the ability to move in multi-robot formations, the ability to snap to angles/gridlines, and higher movement precision. The improved system allows users to control multiple furniture robots, both locally and remotely. Such improvement sets the baseline functionalities of robot furniture arrangement systems while extending the potential utilization of established robotic chairs.
Understanding the Hydrothermal Formation of NaNbO3: Its Full Reaction Scheme and Kinetics (2021)

Sodium niobate (NaNbO<sub>3</sub>) attracts attention for its great potential in a variety of applications, for instance, due to its unique optical properties. Still, optimization of its synthetic procedures is hard due to the lack of understanding of the formation mechanism under hydrothermal conditions. Through <i>in situ</i> X-ray diffraction, hydrothermal synthesis of NaNbO<sub>3</sub> was observed in real time, enabling the investigation of the reaction kinetics and mechanisms with respect to temperature and NaOH concentration and the resulting effect on the product crystallite size and structure. Several intermediate phases were observed, and the relationship between them, depending on temperature, time, and NaOH concentration, was established. The reaction mechanism involved a gradual change of the local structure of the solid Nb<sub>2</sub>O<sub>5</sub> precursor upon suspending it in NaOH solutions. Heating gave a full transformation of the precursor to HNa<sub>7</sub>Nb<sub>6</sub>O<sub>19</sub>·15H<sub>2</sub>O, which destabilized before new polyoxoniobates appeared, whose structure depended on the NaOH concentration. Following these polyoxoniobates, Na<sub>2</sub>Nb<sub>2</sub>O<sub>6</sub>·H<sub>2</sub>O formed, which dehydrated at temperatures ≥285 °C, before converting to the final phase, NaNbO<sub>3</sub>. The total reaction rate increased with decreasing NaOH concentration and increasing temperature. Two distinctly different growth regimes for NaNbO<sub>3</sub> were observed, depending on the observed phase evolution, for temperatures below and above ≈285 °C. Below this temperature, the growth of NaNbO<sub>3</sub> was independent of the reaction temperature and the NaOH concentration, while for temperatures ≥285 °C, the temperature-dependent crystallite size showed the characteristics of a typical dissolution-precipitation mechanism.
Exceptional Wear Resistance of MEMS Devices Coated with Carbon-Doped Alumina Films (2007)

Wear test polysilicon MEMS microstructures coated with a nanometer-thin layer of carbon-rich alumina exhibit the highest time-to-failure documented to date for hard lubricating coatings.
The Commensal Streptococcus salivarius K12 Downregulates the Innate Immune Responses of Human Epithelial Cells and Promotes Host-Microbe Homeostasis (2008)

Streptococcus salivarius is an early colonizer of human oral and nasopharyngeal epithelia, and strain K12 has reported probiotic effects. An emerging paradigm indicates that commensal bacteria downregulate immune responses through the action on NF-kappaB signaling pathways, but additional mechanisms underlying probiotic actions are not well understood. Our objective here was to identify host genes specifically targeted by K12 by comparing their responses with responses elicited by pathogens and to determine if S. salivarius modulates epithelial cell immune responses. RNA was extracted from human bronchial epithelial cells (16HBE14O- cells) cocultured with K12 or bacterial pathogens. cDNA was hybridized to a human 21K oligonucleotide-based array. Data were analyzed using ArrayPipe, InnateDB, PANTHER, and oPOSSUM. Interleukin 8 (IL-8) and growth-regulated oncogene alpha (Groalpha) secretion were determined by enzyme-linked immunosorbent assay. It was demonstrated that S. salivarius K12 specifically altered the expression of 565 host genes, particularly those involved in multiple innate defense pathways, general epithelial cell function and homeostasis, cytoskeletal remodeling, cell development and migration, and signaling pathways. It inhibited baseline IL-8 secretion and IL-8 responses to LL-37, Pseudomonas aeruginosa, and flagellin in epithelial cells and attenuated Groalpha secretion in response to flagellin. Immunosuppression was coincident with the inhibition of activation of the NF-kappaB pathway. Thus, the commensal and probiotic behaviors of S. salivarius K12 are proposed to be due to the organism (i) eliciting no proinflammatory response, (ii) stimulating an anti-inflammatory response, and (iii) modulating genes associated with adhesion to the epithelial layer and homeostasis. S. salivarius K12 might thereby ensure that it is tolerated by the host and maintained on the epithelial surface while actively protecting the host from inflammation and apoptosis induced by pathogens.
Analysis of Deep Brain Stimulation Lead Targeting in the Stimulation of Anterior Nucleus of the Thalamus for Epilepsy Clinical Trial (2021)

Consistent with experience from more established DBS indications, our findings and other recent reports suggest that there may be specific sites within the ANT that are associated with superior clinical outcomes. It will be important to continue to evaluate these relationships and the evolution of other clinical practices (eg, programming) to further optimize this therapy.
Conversion of Thio- and Selenophosphoryl into Phosphoryl Group by Perfluoro cis-2,3-Dialkyloxaziridines (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTConversion of Thio- and Selenophosphoryl into Phosphoryl Group by Perfluoro cis-2,3-DialkyloxaziridinesAlberto Arnone, , Massimo Pregnolato, Giuseppe Resnati, and Marco TerreniView Author Information Dipartimento di Chimica Farmaceutica, Università degli Studi, 12 via Taramelli, I-27100 Pavia, Italy, and C.N.R.-Centro di Studio sulle Sostanze Organiche Naturali, Dipartimento di Chimica, Politecnico, 7 via Mancinelli, I-20131 Milano, ItalyCite this: J. Org. Chem. 1997, 62, 18, 6401–6403Publication Date (Web):September 5, 1997Publication History Received31 March 1997Published online5 September 1997Published inissue 1 September 1997https://pubs.acs.org/doi/10.1021/jo970572ahttps://doi.org/10.1021/jo970572abrief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views401Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical reactions,Oxidation reactions,Phosphorus,Reaction products,Reagents Get e-Alerts
23. LARGE CUFF TEARS IN PATIENTS AGED LESS THAN 65: IMPACT ON ACTIVE RANGE OF MOTION (2011)

Purpose of the study: Little is known about the clinical profile of patients aged less than 65 years who present a large or massive rotator cuff tear. We hypothesized that this clinical profile depends on the type of tear. Material and method: This was a prospective descriptive multicentric study over a period of six months which included 112 patients aged less than 65 years, 66 men and 46 women, mean age 56.3 years (range 35–65) who had a large or massive rotator cuff tear. The Constant score and active and passive range of motion, subacromial height and fatty infiltration according to the Goutallier classification were noted. Patients were divided into four classes according to deficit in active elevation and external rotation: class A (n=55, no deficit), class B (n=19, deficient elevation alone), class C (n=28, deficient external rotation alone), class C (n=10, deficient elevation and external rotation). Results: These classes were not significantly different for age, sex-ratio, duration of symptoms, or presence of subscapular involvement. Trauma was involved more often in patients in class B and class D. The mean absolute Constant score was significantly lower in patients in class B (30.2) or D (23.5) than in class A (53.3) or C (44.7). The subacromial space was significantly narrower in group D (5 mm) than in the other groups. Fatty infiltration of the infraspinatus scores > II was significantly more common in groups C and D. Severe fatty degeneration of the subscapular (>II) was found in only eight shoulders and was not correlated with defective active elevation. Discussion: This study demonstrates that deficient external rotation is correlated with the type of tear but has little impact on the Constant score. Conversely, patients with deficient active elevation have a lower Constant score but do not exhibit characteristically different tears than patients without deficient active elevation. Thus, the management scheme should be no different in patients with deficient elevation than in patients with out deficient elevation, excepting cases with a major lesion of the subscapularis.
Performance metrics for assessment of distribution system protection schemes (2014)

This paper investigates the metrics for assessing the performance of alternative protection schemes for a distribution feeder. In addition to the main criterion which is the system reliability, the paper considers the other important factors as well which include stress on the substation transformer and the impact of momentary interruptions on customer load. Traditional reliability assessment indices, most commonly used amongst utilities, consider sustained interruptions only and hence they do not capture the advantages brought forth due to faster speed of protection schemes. To include the momentary events and their impact, an index `SARFI-ITIC' based on the `ITIC curve' is considered. Test cases illustrate the use of these metrics especially in assessing the advantages of fast speed protection schemes.
Engineered DNA-Mediated Antibody Gene Transfer for Prophylaxis Against Infectious Diseases (2016)

Monoclonal antibodies (mAbs) have become important therapeutic and prophylactic agents for a number of indications, including infectious diseases. However, due to many issues, particularly the high cost of antibody production, mAb therapies are limited to the world’s richest populations. Furthermore, lengthy product development programs mean only a small number of mAb products can be produced at any one time. Engineering novel, low-cost, and simple methods of developing and delivering mAbs would be highly advantageous, potentially expanding the utility of antibody approaches into a wider array of applications. Here, we describe an approach to deliver human IgG neutralizing mAbs in vivo using DNA plasmid-mediated antibody gene transfer. This approach, which we term DNA mAb (DMAb) delivery, generates biologically relevant levels of mAbs after a single intramuscular injection of antibody-encoding DNA followed by in vivo electroporation (EP). First, we developed antibody-encoding DNA plasmids that could reproducibly deliver human mAbs to mouse serum. We show that these plasmid-encoded antibodies have similar binding capacity and functionality to in vitro-produced purified antibodies. Then, we use a mouse model to show that intramuscular delivery of pDVSF-3 LALA, which encodes a human anti-Dengue virus (DENV) IgG1 neutralizing antibody modified with a mutation that abrogates Fcγ receptor binding, produces anti-DENV antisera capable of binding to and neutralizing DENV1-3. Importantly, mice receiving pDVSF-3 LALA, but not the unmodified pDVSF-3 WT, were protected from both virus-only disease and antibody-enhanced lethal disease. To build upon these initial findings, we evaluated targeted genetic approaches and alternative delivery regimens in order to increase DMAb expression in vivo. Using DMAbs encoding human IgG1 antibodies against Borrelia burgdorferi (the causative agent of Lyme disease) as a model, we show that specific amino acid modifications to the framework regions of antibody variable domains confer increased in vitro and in vivo DMAb expression levels compared to the original DMAb sequences. Of note, these modifications were found to have no detrimental effect on the antibody’s borreliacidal activity. Lastly, we observed that pre-treatment of the DMAb injection site with hyaluronidase resulted in a 2.4 to 6.4-fold increase in human IgG concentration levels in vivo compared to mice receiving EP-mediated DMAb delivery only. Taken together, these data establish DNA plasmid-based antibody gene transfer as a safe, effective means of delivering tailored, protective monoclonal antibodies to hosts.
Electrical stimulation of human mesenchymal stem cells on biomineralized conducting polymers enhances their differentiation towards osteogenic outcomes (2015)

Tissue scaffolds allowing the behaviour of the cells that reside on them to be controlled are of particular interest for tissue engineering. Herein we describe biomineralized conducting polymer-based bone tissue scaffolds that facilitate the electrical stimulation of human mesenchymal stem cells, resulting in enhancement of their differentiation towards osteogenic outcomes.
High Tumor DCLK1 Levels at Colorectal Cancer Diagnosis Predict Poor Survival (2015)

Introduction: Colorectal cancer (CRC) is the 3rd most common cancer and cancer death cause in the US. Carcinoembryonic antigen is the only tumor marker with recognized efficacy for CRC. Research to develop more CRC prognostic biomarkers continues. DCLK1, a confirmed CRC tumor stem cell marker, is a biomarker for other gastrointestinal tract cancers (esophageal/pancreatic adenocarcinomas). In addition, a previous cohort of CRC patients demonstrated that DCLK1 immunostaining predicts overall survival. The Cancer Genome Atlas (TCGA) datasets provide an opportunity to assess the relevance of potential prognostic markers in large patient cohorts. Here, we utilize the TCGA colorectal adenocarcinoma (COADREAD) dataset to determine the prognostic value of CRC DCLK1 mRNA expression. Methods: The COADREAD HiSeq V2 dataset (n=364) was downloaded from the UCSC Cancer Genome Browser and analyzed using R and Graphpad Prism 6.0. Patients were divided into DCLK1 expression cohorts using Twitter's BreakoutDetection package (“multi”, α=0.005, β=0.005), which is capable of detecting pattern changes even within noisy data. Standard Kaplan-Meier survival analysis was performed on the cohorts and findings were confirmed using cbioportal.org's survival analysis tool. Results: The COADREAD dataset at the time of analysis consisted of 55, 127, 112, and 52 Stage I, II, III, and IV patient tumors respectively from 198 male and 166 female CRC patients (18 unstaged) with a median age of 66. BreakoutDetection produced 3 patient cohorts based on DCLK1 expression including a cohort consisting of the top 13th percentile (DCLK1high). Overall survival was significantly shorter for those in the most elevated DCLK1high cohort (Fig, p < 0.02). Median survival for DCLK1high patients was 47 months vs 83 months for DCLK1low patients. In addition, 100% of uncensored DCLK1high patients expired by ˜2000 days after initial diagnosis while approximately 36% of uncensored DCLK1low patients survived greater than 4250 days. Moreover, there was no significant difference in tumor stage relative to DCLK1 mRNA expression, indicating stage-dependent effects cannot explain these findings. Conclusion: These findings demonstrate that elevated DCLK1 at CRC diagnosis predicts long-term survival and may be a useful as a prognostic marker in determining individual treatment modalities. Moreover, they further emphasize the need to develop novel therapeutics against DCLK1 and the DCLK1+ tumor stem cell in CRC.Figure 1
Method and apparatus for acoustically monitoring the flow of suspended solid particulate matter (2023)

A method and apparatus for monitoring char flow in a coal gasifier system cludes flow monitor circuits which measure acoustic attenuation caused by the presence of char in a char line and provide a char flow/no flow indication and an indication of relative char density. The flow monitor circuits compute the ratio of signals in two frequency bands, a first frequency band representative of background noise, and a second higher frequency band in which background noise is attenuated by the presence of char. Since the second frequency band contains higher frequencies, the ratio can be used to provide a flow/no flow indication. The second band can also be selected so that attenuation is monotonically related to particle concentration, providing a quantitative measure of char concentration.
Genetic Algorithm Optimization of Dynamic Support Vector Regression (2009)

We show that genetic algorithms (GA) find optimized dynamic support vector machines (DSVMs) more efficiently than the grid search (GS) optimization approach. In addition, we show that GA-DSVMs find extremely low-error solutions for a number of oft-cited benchmarks. Unlike standard support vector machines, DSVMs account for the fact that data further back in a time series are generally less predictive than more-recent data. In order to tune the discounting factors, DSVMs require two new free parameters for a total of five. Because of the five free parameters, traditional GS optimization becomes intractable for even modest grid resolutions. GA optimization finds better results while using fewer computational resources.
An entropy method for floodplain monitoring network design (2012)

In recent years an increasing number of flood-related fatalities has highlighted the necessity of improving flood risk management to reduce human and economic losses. In this framework, monitoring of flood-prone areas is a key factor for building a resilient environment. In this paper a method for designing a floodplain monitoring network is presented. A redundant network of cheap wireless sensors (GridStix) measuring water depth is considered over a reach of the River Dee (UK), with sensors placed both in the channel and in the floodplain. Through a Three Objective Optimization Problem (TOOP) the best layouts of sensors are evaluated, minimizing their redundancy, maximizing their joint information content and maximizing the accuracy of the observations. A simple raster-based inundation model (LISFLOOD-FP) is used to generate a synthetic GridStix data set of water stages.The Digital Elevation Model (DEM) that is used for hydraulic model building is the globally and freely available SRTM DEM.
Abstract C132: Targeting heat shock factor 1 improves the antitumor efficiency of hyperthermia. (2013)

Abstract The heat-shock response is a powerful transcriptional program which acts genome-wide, not only to restore normal protein folding through the induction of heat shock proteins (HSP), but to re-shape global cellular pathways controlling survival, growth and metabolism. In mammals, this response is regulated primarily by the Heat Shock Factor 1 (HSF1) transcription factor. We have previously shown that HSF1 plays a fundamental role in tumorigenesis, by promoting the survival and malignance of tumor cells, both in tissue culture and in mouse models of cancer [1]. HSF1 exerts its role by activating a unique transcriptional program in the cancer cells [2]. Indeed, increased HSF1 levels, as well as activation of its transcriptional signature, are associated with reduced survival in breast, lung and colon cancer patients [3]. Cancer cells are exquisitely dependent on HSF1 for survival. Exposure to additional stress, such as heat, further increases their dependency on HSF1. Recently we described how translation is linked to HSF1 activation using a derivative of the natural compound rocaglamide [4]. We found that this drug-like inhibitor of translation-initiation inhibits HSF1 and leads to tumor regression in hematopoietic malignancies. Here we combine this compound, or genetic inhibition of HSF1 expression, with focal heat therapy delivered via gold nano rods. We find that inhibiting HSF1 in solid tumors increases the efficiency of hyperthermia as an anticancer treatment. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):C132. Citation Format: Ruth Scherz-Shouval, Alexander F. Bagley, Luke Whitesell, Sangeeta N. Bhatia, Susan Lindquist. Targeting heat shock factor 1 improves the antitumor efficiency of hyperthermia. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C132.
Latency Aware Workload Offloading in the Cloudlet Network (2017)

We propose a novel network architecture by leveraging the cloudlet concept, the software defined networking technology, and the cellular network infrastructure to bring the computing resource to the mobile edge. In order to minimize the average response time for mobile users (MUs) in offloading their application workloads to the geographically distributed cloudlets, we propose the latency-aware workload offloading (LEAD) strategy to allocate MUs' application workloads into suitable cloudlets. Simulation results demonstrate that LEAD incurs the lowest average response time as compared with two other existing strategies.