gebhart/patrepeval huggingface dataset:
Catalytic Reduction of NO with NH3 over Cu(II)NaY (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic Reduction of NO with NH3 over Cu(II)NaYTetsuro Selyama, Mamoru Mizumoto, Takasumi Ishihara, and Noboru YamazoeCite this: Ind. Eng. Chem. Prod. Res. Dev. 1979, 18, 4, 279–283Publication Date (Print):December 1, 1979Publication History Published online1 May 2002Published inissue 1 December 1979https://pubs.acs.org/doi/10.1021/i360072a011https://doi.org/10.1021/i360072a011research-articleACS PublicationsRequest reuse permissionsArticle Views34Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
An epigenetic regulator-related score (EpiScore) predicts survival in patients with diffuse large B cell lymphoma and identifies patients who may benefit from epigenetic therapy (2018)

Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma and shows considerable clinical and biological heterogeneity. Much research is currently focused on the identification of prognostic markers for more specific patients' risk stratification and on the development of therapeutic approaches to improve the long-term outcome. Epigenetic alterations are involved in various cancers, including lymphoma. Interestingly, epigenetic alterations are reversible and drugs to target some of them have been developed. In this study, we demonstrated that the gene expression profile of epigenetic regulators has a prognostic value in DLBCL and identified pathways that could be involved in DLBCL poor outcome. We then designed a new risk score (EpiScore) based on the gene expression level of the epigenetic regulators DNMT3A, DOT1L, SETD8. EpiScore was predictive of overall survival in DLBCL and allowed splitting patients with DLBCL from two independent cohorts (<i>n =</i> 414 and <i>n =</i> 69) in three groups (high, intermediate and low risk). EpiScore was an independent predictor of survival when compared with previously described prognostic factors, such as the International Prognostic Index (IPI), germinal center B cell and activated B cell molecular subgroups, gene expression-based risk score (GERS) and DNA repair score. Immunohistochemistry analysis of DNMT3A in 31 DLBCL samples showed that DNMT3A overexpression (>42% of positive tumor cells) correlated with reduced overall and event-free survival. Finally, an HDAC gene signature was significantly enriched in the DLBCL samples included in the EpiScore high-risk group. We conclude that EpiScore identifies high-risk patients with DLBCL who could benefit from epigenetic therapy.
Comparison of the influence of PM drive system with voltage adaptation or machine winding reconfiguration on HEV/EV applications (2015)

This paper examines the performance benefits of four IPM drive system configurations for HEV/EV applications with the following features for controlling the machine voltage: 1) boosted inverter, 2) Y/Δ, 3) series/parallel (S/P) and 4) tapped reconfigurable windings. The four systems are modeled and their impact on drive system performance is investigated. Additionally, comparisons in terms of flux weakening capability, torque, output power, losses, number of machine winding leads and number of added components are studied in detail. Detailed set of simulation and experiments results were used for assessing the performance benefits. The trade-off study shows that the drive system with tapped reconfigurable winding results in the favorable cost/benefit ratio with similar inverter voltage/current limits.
Optimization of Multimeric Human Papillomavirus L2 Vaccines (2013)

We sought to define the protective epitopes within the amino terminus of human papillomavirus (HPV) type 16 minor capsid protein L2. Passive transfer of mice with rabbit antisera to HPV16 L2 peptides 17-36, 32-51 and 65-81 provided significant protection against vaginal HPV16 challenge, whereas antisera to 47-66, 108-120 or 373-392 did not. Vaccination with L1 virus-like particles induces a high titer, but generally type-restricted neutralizing antibody response. Conversely, vaccination with L2 11-88, especially multimers thereof, induces antibodies that neutralize a broad range of papillomavirus types, albeit at lower titers than for L1 VLP. With the intent of enhancing the immunogenicity and the breadth of protection by focusing the immune response to the key protective epitopes, we designed L2 fusion proteins consisting of residues ∼11-88 of eight divergent mucosal HPV types 6, 16, 18, 31, 39, 51, 56, 73 (11-88×8) or residues ∼13-47 of fifteen HPV types (13-47×15). The 11-88×8 was significantly more immunogenic than 13-47×15 in Balb/c mice regardless of the adjuvant used, suggesting the value of including the 65-81 protective epitope in the vaccine. Since the L2 47-66 peptide antiserum failed to elicit significant protection, we generated an 11-88×8 construct deleted for this region in each subunit (11-88×8Δ). Mice were vaccinated with 11-88×8 and 11-88×8Δ to determine if deletion of this non-protective epitope enhanced the neutralizing antibody response. However, 11-88×8Δ was significantly less immunogenic than 11-88×8, and even the addition of a known T helper epitope, PADRE, to the construct (11-88×8ΔPADRE) failed to recover the immunogenicity of 11-88×8 in C57BL/6 mice, suggesting that while L2 47-66 is not a critical protective or T helper epitope, it nevertheless contributes to the immunogenicity of the L2 11-88×8 multimer vaccine.
Distributed Inter-Cell Interference Mitigation Via Joint Scheduling and Power Control Under Noise Rise Constraints (2012)

Consider the problem of joint uplink scheduling and power allocation. Being inherent to almost any wireless system, this resource allocation problem has received extensive attention. Yet, most common techniques either adopt classical power control, in which mobile stations are received with the same Signal-to-Interference-plus-Noise Ratio, or use centralized schemes, in which base stations coordinate their allocations. In this work, we suggest a novel scheduling approach in which each base station, besides allocating the time and frequency according to given constraints, also manages its uplink power budget such that the aggregate interference, "Noise Rise", caused by its subscribers at the neighboring cells is bounded. Our suggested scheme is distributed, requiring neither coordination nor message exchange. We rigorously define the allocation problem under noise rise constraints, give the optimal solution and derive an efficient iterative algorithm to achieve it. We then discuss a relaxed problem, where the noise rise is constrained separately for each sub-channel or resource unit. While sub-optimal, this view renders the scheduling and power allocation problems separate, yielding an even simpler and more efficient solution, while the essence of the scheme is kept. Via extensive simulations, we show that the suggested approach increases overall performance dramatically, with the same level of fairness and power consumption.
Techno-Economic, Feasibility, and Life Cycle Analysis of Renewable Propane (Final Report) (2022)

The Propane Education and Research Council (PERC) has engaged with the National Renewable Energy Laboratory (NREL) to develop information that is critical to understanding the current and future landscape for renewable propane (RP) and the value proposition for recovery of RP from existing and planned HEFA biorefineries. In summary the following outcomes are identified from this study: (1) production of incremental RP by increasing the severity of the hydroisomerization step is insignificant to the overall propane yield from a HEFA biorefinery, however production of renewable butane (or LPG2) is quite significant thus suggesting alternate strategies for valorizing these fractions; (2) the value proposition for recovering RP and renewable LPG is quite strong, with capital recovery payback periods of 14 months for a small biorefinery producing 3.5 million gallons per year RP to as short as 2 months for a large biorefinery producing 87 million gallons per year RP. Paybacks for renewable LPG are as much as 50% shorter; and (3) current and projected expansions of renewable diesel will greatly expand the potential availability of RP as a by-product. Several promising new pathways are under development but will not significantly increase production of RP for the next decade.
Improving Document Ranking with Dual Word Embeddings (2016)

This paper investigates the popular neural word embedding method Word2vec as a source of evidence in document ranking. In contrast to NLP applications of word2vec, which tend to use only the input embeddings, we retain both the input and the output embeddings, allowing us to calculate a different word similarity that may be more suitable for document ranking. We map the query words into the input space and the document words into the output space, and compute a relevance score by aggregating the cosine similarities across all the query-document word pairs. We postulate that the proposed Dual Embedding Space Model (DESM) provides evidence that a document is about a query term, in addition to and complementing the traditional term frequency based approach.
Engineering of Osmium(II)‐Based Light Absorbers for Dye‐Sensitized Solar Cells (2012)

Panchromatische OsII-Sensibilisatoren für farbstoffsensibilisierte Solarzellen (DSCs) wurden hergestellt. Eine DSC aus dem Komplex TF-52 (siehe Bild) hat vielversprechende Kenngrößen: eine Kurzschlussphotostromdichte JSC von 23.3 mA cm−2, eine Leerlaufspannung VOC von 600 mV, einen Füllfaktor FF von 0.633 und einen Wirkungsgrad η von 8.85 % im AM-1.5G-Spektrum.
Study of the Role of Cytosolic Phospholipase A2 Alpha in Eicosanoid Generation and Thymocyte Maturation in the Thymus (2015)

The thymus is a primary lymphoid organ, home of maturation and selection of thymocytes for generation of functional T-cells. Multiple factors are involved throughout the different stages of the maturation process to tightly regulate T-cell production. The metabolism of arachidonic acid by cyclooxygenases, lipoxygenases and specific isomerases generates eicosanoids, lipid mediators capable of triggering cellular responses. In this study, we determined the profile of expression of the eicosanoids present in the mouse thymus at different stages of thymocyte development. As the group IVA cytosolic phospholipase A2 (cPLA2α) catalyzes the hydrolysis of phospholipids, thereby generating arachidonic acid, we further verified its contribution by including cPLA2α deficient mice to our investigations. We found that a vast array of eicosanoids is expressed in the thymus, which expression is substantially modulated through thymocyte development. The cPLA2α was dispensable in the generation of most eicosanoids in the thymus and consistently, the ablation of the cPLA2α gene in mouse thymus and the culture of thymuses from human newborns in presence of the cPLA2α inhibitor pyrrophenone did not impact thymocyte maturation. This study provides information on the eicosanoid repertoire present during thymocyte development and suggests that thymocyte maturation can occur independently of cPLA2α.
An analytical method for the wave force on a long array of cylinders in a two-layer fluid (2009)

An analytical method is used to analyze the wave force of a long array of cylinders in a two-layer fluid acted by linear waves.The analytic expressions for the scattering potential functions are obtained by using the multipole expansion method,and expressions for the wave force are defined.A boundary element method is used to verify the correctness of the present analytical method.Finally,the analytical results of the wave force on cylinders are studied for some different parameters.
Multi-Level Policy and Reward Reinforcement Learning for Image Captioning (2018)

Image captioning is one of the most challenging hallmark of AI, due to its complexity in visual and natural language understanding. As it is essentially a sequential prediction task, recent advances in image captioning use Reinforcement Learning (RL) to better explore the dynamics of word-by-word generation. However, existing RL-based image captioning methods mainly rely on a single policy network and reward function that does not well fit the multi-level (word and sentence) and multi-modal (vision and language) nature of the task. To this end, we propose a novel multi-level policy and reward RL framework for image captioning. It contains two modules: 1) Multi-Level Policy Network that can adaptively fuse the word-level policy and the sentence-level policy for the word generation; and 2) Multi-Level Reward Function that collaboratively leverages both vision-language reward and language-language reward to guide the policy. Further, we propose a guidance term to bridge the policy and the reward for RL optimization. Extensive experiments and analysis on MSCOCO and Flickr30k show that the proposed framework can achieve competing performances with respect to different evaluation metrics.
Abstract 2792: Characterization of spontaneous in vivo cachexia models in Champions TumorGraft™ models. (2013)

Abstract Cachexia, defined as a loss of adipose tissue and skeletal muscle mass not reversible by nutritional support, is present in the majority of patients with advanced cancer progression. This reduces the patient's quality of life and impacts their ability to function normally and undergo treatments. Reversing cachexia has been problematic due to a lack of quality pre-clinical models. Traditional xenograft models using cell lines are limited due to their inability to accurately replicate the whole body response to cancer. Champions Oncology overcomes this challenge through the use of its innovative Champions TumorGraft™ platform, where primary human tumors are implanted into immunocompromised mice in a manner that preserves the biological properties of the original human tumor. Champions has identified a panel of three TumorGraft models which spontaneously induce cachexia when implanted subcutaneously into nude mice: 1) CTG-0282, a pancreatic cancer model, 2) CTG-0765, a NSCLC model, and 3) CTG-0804, a renal cell carcinoma model. All three models have shown a greater than 90% cachexia rate, as demonstrated by lost body weight, over multiple passages. In addition, loss of body weight correlates with an increase in tumor volume size. Mice that have little or no tumor growth show no loss of body weight. Past studies have indicated a function for pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin 1 (IL-1), interleukin 6 (IL-6) and interferon gamma (IFNγ), in the cachexia process. Champions is currently investigating the roles of these possible tumor-mediated factors in the aforementioned models. Principle among these factors is IL-6, which has been shown to be required in the regulation of cachexia in tumor-bearing mice and is correlated with weight loss and survival in patients. Preliminary results from our studies suggest a correlation between IL-6 levels and spontaneous cachexia in Champions TumorGraft models. In summary, we demonstrate that the Champions TumorGraft platform preserves the biological properties of the original human tumor, including spontaneous cachexia behavior in these models, and is therefore ideal for oncology drug development programs focused on the inhibition of cachexia. Citation Format: Nathan Anderson, Tin Oo Khor, Andrew Feldhaus, Katie Olson, John Latham, David Sidransky, Elizabeth M. Bruckheimer. Characterization of spontaneous in vivo cachexia models in Champions TumorGraft™ models. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2792. doi:10.1158/1538-7445.AM2013-2792
A Hardware-Accelerated Reduced Dimensionality Multi-Prototype Learning and Recognition System with complementary classifiers (2013)

Real-time performance is necessary for many computer vision and machine learning systems in the robotics and automotive domains. Hardware based solutions can meet the demands of real-time applications. Support Vector Machines have demonstrated to be one of the best performing general purpose classifiers, however the approach requires significant simplifications to satisfy hardware constraints. Conversely, associative memory based architectures are inherently hardware friendly and have proven to be a promising approach for high-speed computer vision and machine learning applications, but the accuracies of these systems have not been satisfactory. This paper extends the concept of hardware associative memories and reports an FPGA Accelerated Complementary Reduced Dimensionality Multi-Prototype Learning and Recognition System which is composed of discriminative Reduced Dimensionality Multi-Prototype classifiers. To test the performance, the system is applied to human detection. In addition to outperforming general purpose support vector machine based systems, the complementary approach demonstrated a combined detection time of only 14.9 μs per sample.
Linkage of Autosomal Dominant Radial Drusen (Malattia Leventinese) to Chromosome 2p16-21 (1996)

The gene responsible for autosomal dominant radial drusen has been mapped to the short arm of chromosome 2. This is an important step toward actually isolating the disease-causing gene. In addition, this information can be used to evaluate other familial drusen phenotypes such as Doyne's macular dystrophy for a possible allelic relationship.
EFFECT OF ANTI-CD4 MONOCLONAL ANTIBODY COMBINED WITH HUMAN CTLA4Ig ON THE SURVIVAL OF HAMSTER LIVER AND HEART XENOGRAFTS IN LEWIS RATS (1997)

We investigated the effects of pretransplant anti-CD4 monoclonal antibody (mAb) combined with human (h) CTLA4Ig on the survival of hamster heart and liver xenografts. Pretransplant anti-CD4 mAb (5 mg/kg x 4 days) or hCTLA4Ig (0.5 mg/rat on days 1, 3, and 5 after transplantation) treatment alone prolonged the survival of hamster liver xenografts in Lewis rats (mean survival time [MST]=10.5 days, n=6, and MST=9.0 days, n=5, respectively, compared with untreated Lewis recipients of hamster liver grafts, MST=6.0 days, n=6). The same regimen could not prevent hamster heart xenorejection. Pretransplant anti-CD4 mAb (5 mg/kg x 4 days) combined with hCTLA4Ig (0.5 mg/rat x 4) treatments increased survival of hamster liver xenograft fourfold (MST=24.2 days, n=5). The current results also show that IgG in the sera from Lewis recipients of hamster liver grafts treated with anti-CD4 mAb and hCTLA4Ig was threefold reduced at 6 days after transplantation compared with untreated Lewis rats. These results suggest a synergistic effect of anti-CD4 mAb combined with hCTLA4Ig in a liver xenograft transplantation model.
H+-K+-ATPases: regulation and role in pathophysiological states (1999)

Molecular cloning experiments have identified the existence of two H+-K+-ATPases (HKAs), colonic and gastric. Recent functional and molecular studies indicate the presence of both transporters in the kidney, which are presumed to mediate the exchange of intracellular H+ for extracellular K+. On the basis of these studies, a picture is evolving that indicates differential regulation of HKAs at the molecular level in acid-base and electrolyte disorders. Of the two transporters, gastric HKA is expressed constitutively along the length of the collecting duct and is responsible for H+ secretion and K+ reabsorption under normal conditions and may be stimulated with acid-base perturbations and/or K+ depletion. This regulation may be species specific. To date there are no data to indicate that the colonic HKA (HKAc) plays a role in H+ secretion or K+ reabsorption under normal conditions. However, HKAc shows adaptive regulation in pathophysiological conditions such as K+ depletion, NaCl deficiency, and proximal renal tubular acidosis, suggesting an important role for this exchanger in potassium, HCO-3, and sodium (or chloride) reabsorption in disease states. The purpose of this review is to summarize recent functional and molecular studies on the regulation of HKAs in physiological and pathophysiological states. Possible signals responsible for regulation of HKAs in these conditions will be discussed. Furthermore, the role of these transporters in acid-base and electrolyte homeostasis will be evaluated in the context of genetically altered animals deficient in HKAc.
WLC21-6: Protocol-Aware Design Criteria and Performance Analysis for Distributed Space-Time Coding (2006)

In this paper, we consider the design of distributed space-time codes for wireless networks. Distributed space-time coding (DSTC) can be achieved through node cooperation to emulate multiple transmit antennas. We derive the distributed space-time codes design criteria for different scenarios based on the pairwise error probability (PEP) analysis. First, we consider the decode-and-forward (DAF) protocol and prove that space-time codes, designed to achieve full diversity and maximum coding gain in the MIMO channels, will achieve full diversity but not necessarily maximizing the coding gain if used with the DAF protocol. Next, we consider the amplify-and-forward (AAF) protocol and prove that a space-time code designed to achieve full diversity and maximum coding gain in MIMO channels will achieve the same if used with the AAF protocol.
Magnetic Particle Plug-Based Assays for Biomarker Analysis (2016)

Conventional immunoassays offer selective and quantitative detection of a number of biomarkers, but are laborious and time-consuming. Magnetic particle-based assays allow easy and rapid selection of analytes, but still suffer from the requirement of tedious multiple reaction and washing steps. Here, we demonstrate the trapping of functionalised magnetic particles within a microchannel for performing rapid immunoassays by flushing consecutive reagent and washing solutions over the trapped particle plug. Three main studies were performed to investigate the potential of the platform for quantitative analysis of biomarkers: (i) a streptavidin-biotin binding assay; (ii) a sandwich assay of the inflammation biomarker, C-reactive protein (CRP); and (iii) detection of the steroid hormone, progesterone (P4), towards a competitive assay. Quantitative analysis with low limits of detection was demonstrated with streptavidin-biotin, while the CRP and P4 assays exhibited the ability to detect clinically relevant analytes, and all assays were completed in only 15 min. These preliminary results show the great potential of the platform for performing rapid, low volume magnetic particle plug-based assays of a range of clinical biomarkers via an exceedingly simple technique.