gebhart/patrepeval huggingface dataset:
[Effect of improper pulmonary venous compliance on clinical results of mitral valve replacement]. (1993)

The pulmonary venous vascular volume and its compliance (PVcomp) are important factors influencing filling of the left ventricle. It seems that a poor PVcomp effects the value and reversibility of secondary pulmonary hypertension. Basing on Hirakawa's method PVcomp (= 0.4'' x SV/V-d) was calculated in 34 patients with isolated mitral stenosis (SM). Basing on the mean value of PVcomp the group was divided into those with poor (< = 4.3 ml/mmHg) and good (4.4 and more ml/mmHg) PVcomp. Prior mitral valve replacement (MVR) the groups did not differ in values of PAP, PWP, SVI, PVR assessed at rest. During exercise (25 Watt) in the supine position significant higher values of PAP and PWP were observed in patients with poor compliance. Six months after MVR the PAP and PWP values normalized in all patients. In the patients with the initial good PVcomp values significantly higher values of SVI and a decrease in PVR was found. During exercise (25 Watts) significantly higher values of PAP and PVR were registered in patients with initial poor PVcomp values. Pulmonary venous compliance may be an independent factors influencing the clinical outcome of mitral valve replacement 6 months after the procedure.
Business Processes Meet Operational Business Intelligence. (2009)

As Business Intelligence architectures evolve from off-line strategic decision-making to on-line operational decision-making, the design of the backend Extract-Transform-Load (ETL) processes is becoming even more complex. We describe the challenges in ETL design and implementation, and the approach we are taking to meet these challenges. Our approach is centered around a layered methodology that starts with modeling the business processes of the enterprise, and their information requirements and service level objectives, and proceeds systematically through logical design to physical implementation. A key element of this approach is the explicit specification of a variety of quality objectives (we call these collectively the QoX objectives) at the business level, and the use of these objectives to drive the optimization of the design at the logical and physical levels. 1
18F-EF5 PET Is Predictive of Response to Fractionated Radiotherapy in Preclinical Tumor Models (2015)

We evaluated the relationship between pre-treatment positron emission tomography (PET) using the hypoxic tracer 18F-[2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3- pentafluoropropyl) acetamide] (18F-EF5) and the response of preclinical tumor models to a range of fractionated radiotherapies. Subcutaneous HT29, A549 and RKO tumors grown in nude mice were imaged using 18F-EF5 positron emission tomography (PET) in order to characterize the extent and heterogeneity of hypoxia in these systems. Based on these results, 80 A549 tumors were subsequently grown and imaged using 18F-EF5 PET, and then treated with one, two, or four fraction radiation treatments to a total dose of 10-40 Gy. Response was monitored by serial caliper measurements of tumor volume. Longitudinal post-treatment 18F-EF5 PET imaging was performed on a subset of tumors. Terminal histologic analysis was performed to validate 18F-EF5 PET measures of hypoxia. EF5-positive tumors responded more poorly to low dose single fraction irradiation relative to EF5-negative tumors, however both groups responded similarly to larger single fraction doses. Irradiated tumors exhibited reduced 18F-EF5 uptake one month after treatment compared to control tumors. These findings indicate that pre- treatment 18F-EF5 PET can predict the response of tumors to single fraction radiation treatment. However, increasing the number of fractions delivered abrogates the difference in response between tumors with high and low EF5 uptake pre-treatment, in agreement with traditional radiobiology.
Low Power Motion Detection with Low Spatial and Temporal Resolution for CMOS Image Sensor (2007)

Video surveillance aims at detecting unexpected individuals or objects intrusion. When no motion is observed, common motion detection systems induce huge power consumption, regardless of the scene activity. This paper presents algorithms for low power motion detection, and their possible implementation. The main interest is that they are able to adapt the sensor's acuity according to the scene activity. Relevant motion information can be extracted from images with lowered spatial and temporal resolution, with specific algorithms. By reducing the amount of data to analyze and spatial and temporal redundancy, a drastic reduction of power consumption can be achieved.
CORRELATION OF INDOCYANINE GREEN ANGIOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY FINDINGS AFTER INTRAVITREAL RANIBIZUMAB FOR POLYPOIDAL CHOROIDAL VASCULOPATHY (2012)

Indocyanine green angiography and OCT baseline findings of polypoidal lesions in polypoidal choroidal vasculopathy were well correlated; however, a discrepancy was seen during treatment. Polypoidal lesions persisted more often on OCT, although ICGA and OCT showed the efficacy of ranibizumab for some polypoidal lesions.
Anti-cancer and Antibacterial Trioxacarcins with High Anti-malaria Activity from a Marine Streptomycete and their Absolute Stereochemistry (2004)

The ethyl acetate extract from the Streptomyces sp. isolate B8652 delivered the trioxacarcins A to approximately C (2a to approximately 2c) and additionally three new derivatives designated as trioxacarcins D to approximately F (2d to approximately 2f). All trioxacarcins showed high anti-bacterial and some of them high anti-tumor and anti-malaria activity. The structures of the new antibiotics were derived from mass, 1D and 2D NMR spectra and confirmed by comparison of the NMR data with those of known derivatives. The absolute configuration of the trioxacarcins is deduced from the X-ray analysis of gutingimycin (2g) and from the known stereochemistry of the L-trioxacarcinoses A and B.
Identification of a novel, widespread, and functionally important PCNA-binding motif (2009)

Numerous proteins, many essential for the DNA replication machinery, interact with proliferating cell nuclear antigen (PCNA) through the PCNA-interacting peptide (PIP) sequence called the PIP box. We have previously shown that the oxidative demethylase human AlkB homologue 2 (hABH2) colocalizes with PCNA in replication foci. In this study, we show that hABH2 interacts with a posttranslationally modified PCNA via a novel PCNA-interacting motif, which we term AlkB homologue 2 PCNA-interacting motif (APIM). We identify APIM in >200 other proteins involved in DNA maintenance, transcription, and cell cycle regulation, and verify a functional APIM in five of these. Expression of an APIM peptide increases the cellular sensitivity to several cytostatic agents not accounted for by perturbing only the hABH2-PCNA interaction. Thus, APIM is likely to mediate PCNA binding in many proteins involved in DNA repair and cell cycle control during genotoxic stress.
Occult hypoperfusion and changes of systemic lipid levels after severe trauma: an analysis in a standardized porcine polytrauma model (2022)

Six lipid groups increased significantly only in the R group at 2 h, which may support the idea that they could serve as potential biomarkers to help us to detect the presence of occult hypoperfusion and insufficient resuscitation. We feel that further study is required to confirm the role and mechanism of lipid changes after trauma.
Tantalum-tungsten alloy photonic crystals for high-temperature energy conversion systems (2014)

A tantalum tungsten (Ta-W) solid solution alloy, Ta 3% W, based 2D photonic crystal (PhC) was designed and fabricated for high-temperature energy conversion applications. Metallic PhCs are promising as high performance selective thermal emitters for solid-state thermal-to-electricity energy conversion concepts including thermophotovoltaic (TPV) energy conversion, as well as highly selective solar absorbers/emitters for solar thermal and solar TPV applications due to the ability to tune their spectral properties and achieve highly selective emission. The mechanical and thermal stability of the substrate was characterized as well as the optical properties of the fabricated PhC. The Ta 3% W alloy presents advantages compared to the non-alloys as it combines the better high-temperature thermo-mechanical properties of W with the more compliant material properties of Ta, allowing for a direct system integration path of the PhC as selective emitter/absorber into a spectrum of energy conversion systems. Furthermore, the thermo-mechanical properties can be fine-tuned by the W content. A 2D PhC was designed to have high spectral selectivity matched to the bandgap of a TPV cell using numerical simulations and fabricated using standard semiconductor processes. The emittance of the Ta 3% W PhC was obtained from near-normal reflectance measurements at room temperature before and after annealing at 1200°C for 24h in vacuum with a protective coating of 40nm HfO2, showing high selectivity in agreement with simulations. SEM images of the cross section of the PhC prepared by FIB confirm the structural stability of the PhC after anneal, i.e. the coating effectively prevented structural degradation due to surface diffusion.
Supplemental Figure 2 from Spatially Resolved Metabolic Phenotyping of Breast Cancer by Desorption Electrospray Ionization Mass Spectrometry (2023)

&lt;p&gt;Supplemental Figure 2. Plots showing the logarithmic intensity distribution of several highly predictive compounds in normal glandular tissue and tumors of different grade and hormone receptor status.&lt;/p&gt;
Multi-core data analytics SoC with a flexible 1.76 Gbit/s AES-XTS cryptographic accelerator in 65 nm CMOS (2017)

Embedded systems for Internet-of-Things applications present new challenges to system design. From a hardware design perspective, energy efficiency is paramount, as most of devices have a limited power supply due to size considerations. Transmitting data away from the node remains a very power hungry operation, and the only viable solution to this problem is to reduce the amount of data by performing pre-processing which again requires additional computational power. Hence modern embedded devices need to strike a fine balance between the power needed for acquisition/processing and communication. In many scenarios, small IoT devices will be deployed widely making them vulnerable to malicious attacks. Thus, for practical applications, these devices also need to fit the necessary resources to provide adequate security services.
Topographic reorganization of the hand representation in cortical area 3b owl monkeys trained in a frequency-discrimination task (1992)

1. Adult owl monkeys were trained to detect differences in the frequency of a tactile flutter-vibration stimulus above a 20-Hz standard. All stimuli were delivered to a constant skin site restricted to a small part of a segment of one finger. The frequency-difference discrimination performance of all but one of these monkeys improved progressively with training. 2. The distributed responses of cortical neurons ("maps") of the hand surfaces were defined in detail in somatosensory cortical area 3b. Representations of trained hands were compared with those of the opposite, untrained hand, and to the area 3b representations of hands in a second set of monkeys that were stimulated tactually in the same manner while these monkeys were attending to auditory stimuli (passive stimulation controls). 3. The cortical representations of the trained hands were substantially more complex in topographic detail than the representations of unstimulated hands or of passively stimulated control hands. 4. In all well-trained monkeys the representations of the restricted skin location trained in the behavioral task were significantly (1.5 to greater than 3 times) greater in area than were the representations of equivalent skin locations on control digits. However, the overall extents of the representations of behaviorally stimulated fingers were not larger than those of control fingers in the same hemisphere, or in opposite hemisphere controls. 5. The receptive fields representing the trained skin were significantly larger than receptive fields representing control digits in all but one trained monkey. The largest receptive fields were centered in the zone of representation of the behaviorally engaged skin, but they were not limited to it. Large receptive fields were recorded in a 1- to 2-mm-wide zone in the area 3b maps of trained hands. 6. Receptive-field sizes were also statistically significantly larger on at least one adjacent, untrained digit when compared with the receptive fields recorded on the homologous digit of the opposite hand. 7. There was an increase in the percent overlaps of receptive fields in the cortical zone of representation of the trained skin. A significant number of receptive fields were centered on the behaviorally trained skin site. 8. The effects of increased topographic complexity, increased representation of the trained skin location, increased receptive-field size, and increased receptive-field overlap were not observed in the representations of the untrained hands in these same monkeys. Only modest increases in topographic complexity were recorded in the representations of passively stimulated hands, and no effects on receptive-field size or overlap were noted.(ABSTRACT TRUNCATED AT 400 WORDS)
A C70-carbon nanotube complex for bulk heterojunction photovoltaic cells (2013)

A C70 fullerene-multi-walled carbon nanotube (C70-CNT) complex has been used as a component of the photoactive layer in a bulk heterojunction photovoltaic cell. As compared to a control device with only C70, the addition of CNTs led to improvements in short circuit current density (Jsc), open circuit voltage (Voc), and power conversion efficiency by 31.8, 17.5, and 69.5%, respectively. This device takes advantage of both the electron accepting feature of C70 and the high electron transport capability of CNTs. These results indicate that C70 decorated CNT is a promising additive for performance enhancement of polymer photovoltaic cells.
Thermo- and pH- responsive nanogels of poly(N-vinylcaprolactam-co-acrylic acid): synthesis and characterization (2010)

International audience
P‐106: Real‐Time Inspection of a Moisture Barrier Film Buried by a Protective Layer for Flexible Displays (2010)

Abstract Stress‐induced cracks in moisture barriers may lead to device degradation in flexible displays. We developed an optical technique that can inspect the cracking of stressed barrier films buried by protective layers. This technique allows rapid and large‐area evaluation of mechanical reliability of moisture barriers and functional layers for flexible displays.
Rupture threshold characterization of polymer-shelled ultrasound contrast agents subjected to static overpressure (2011)

Polymer-shelled micro-bubbles are employed as ultrasound contrast agents (UCAs) and vesicles for targeted drug delivery. UCA-based delivery of the therapeutic payload relies on ultrasound-induced shell rupture. The fragility of two polymer-shelled UCAs manufactured by Point Biomedical or Philips Research was investigated by characterizing their response to static overpressure. The nominal diameters of Point and Philips UCAs were 3 μm and 2 μm, respectively. The UCAs were subjected to static overpressure in a glycerol-filled test chamber with a microscope-reticule lid. UCAs were reconstituted in 0.1 mL of water and added over the glycerol surface in contact with the reticule. A video-microscope imaged UCAs as glycerol was injected (5 mL∕h) to vary the pressure from 2 to 180 kPa over 1 h. Neither UCA population responded to overpressure until the rupture threshold was exceeded, which resulted in abrupt destruction. The rupture data for both UCAs indicated three subclasses that exhibited different rupture behavior, although their mean diameters were not statistically different. The rupture pressures provided a measure of UCA fragility; the Philips UCAs were more resilient than Point UCAs. Results were compared to theoretical models of spherical shells under compression. Observed variations in rupture pressures are attributed to shell imperfections. These results may provide means to optimize polymeric UCAs for drug delivery and elucidate associated mechanisms.
In Vitro Culture and Directed Osteogenic Differentiation of Human Pluripotent Stem Cells on Peptides-Decorated Two-Dimensional Microenvironment (2015)

Human pluripotent stem cells (hPSCs) are a promising cell source with pluripotency and capacity to differentiate into all human somatic cell types. Designing simple and safe biomaterials with an innate ability to induce osteoblastic lineage from hPSCs is desirable to realize their clinical adoption in bone regenerative medicine. To address the issue, here we developed a fully defined synthetic peptides-decorated two-dimensional (2D) microenvironment via polydopamine (pDA) chemistry and subsequent carboxymethyl chitosan (CMC) grafting to enhance the culture and osteogenic potential of hPSCs in vitro. The hPSCs including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) were successfully cultured on the peptides-decorated surface without Matrigel and ECM protein coating and underwent promoted osteogenic differentiation in vitro, determined from the alkaline phosphate (ALP) activity, gene expression, and protein production as well as calcium deposit amount. It was found that directed osteogenic differentiation of hPSCs was achieved through a peptides-decorated niche. This chemically defined and safe 2D microenvironment, which facilitates proliferation and osteo-differentiation of hPSCs, not only helps to accelerate the translational perspectives of hPSCs but also provides tissue-specific functions such as directing stem cell differentiation commitment, having great potential in bone tissue engineering and opening new avenues for bone regenerative medicine.
Identification of a HindIII and a Taql RFLP at the acid alpha glucosidase (GAA) locus (1991)

A 1.9 kb cDNA EcoRI segment subcloned into pUC 19 (GAA67; '2 kb') (1). Polymorphisms: Hindm detects a two allele polymorphism 5.6 kb (Al) and 5.3 kb (A2). TaqI detects a two allele polymorphism 10 kb (Al) and 9 kb (A2). Frequency: HindIH: studied in 22 unrelated Caucasians, gene frequency of 5.6 kb allele = 0.05 and of 5.3 kb allele = 0.95, heterozygosity = 0.09. TaqI: studied in 25 unrelated Caucasians, gene frequency of 10 kb allele = 0.94 and of 9 kb allele = 0.06, heterozygosity = 0.12. Chromosomal Localization: 17q23. Mendelian Inheritance: Hindm: Six matings studied were all monomorphic. However, the frequencies of heterozygotes and homozygotes among independent non-family members fit Hardy- Weinberg equilibrium. TaqI: Co-dominant inheritance in three matings with three offspring; gene frequencies fit Hardy-Weinberg equilibrium.
Peritoneal dialysis (2016)

This chapter includes sections on principles of peritoneal dialysis, types of peritoneal dialysis (continuous ambulatory peritoneal dialysis and automated peritoneal dialysis), prescribing peritoneal dialysis, catheter insertion, technique failure, peritonitis, exit site infection, complications, measurement of dialysis adequacy, assessment of peritoneal membrane function, and encapsulating peritoneal sclerosis.
Architecting for power management: The IBM&#x00AE; POWER7&#x2122; approach (2010)

The POWER7 processor is the newest member of the IBM POWER <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> family of server processors. With greater than 4X the peak performance and the same power budget as the previous generation POWER6 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> , POWER7 will deliver impressive energy-efficiency boosts. The improved peak energy-efficiency is accompanied by a wide array of new features in the processor and system designs that advance IBM's EnergyScale <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> dynamic power management methodology. This paper provides an overview of these new features, which include better sensing, more advanced power controls, improved scalability for power management, and features to address the diverse needs of the full range of POWER servers from blades to supercomputers. We also highlight three challenges that need attention from a range of systems design and research teams: (i) power management in highly virtualized environments, (ii) power (in)efficiency of systems software and applications, and (iii) memory power costs, especially for servers with large memory footprints.
Smell and taste changes are early indicators of the COVID-19 pandemic and political decision effectiveness (2020)

In response to the COVID-19 pandemic, many governments have taken drastic measures to avoid an overflow of intensive care units. Accurate metrics of disease spread are critical for the reopening strategies. Here, we show that self-reports of smell/taste changes are more closely associated with hospital overload and are earlier markers of the spread of infection of SARS-CoV-2 than current governmental indicators. We also report a decrease in self-reports of new onset smell/taste changes as early as 5 days after lockdown enforcement. Cross-country comparisons demonstrate that countries that adopted the most stringent lockdown measures had faster declines in new reports of smell/taste changes following lockdown than a country that adopted less stringent lockdown measures. We propose that an increase in the incidence of sudden smell and taste change in the general population may be used as an indicator of COVID-19 spread in the population.
Oxygen Precursor to the Reactive Intermediate in Methanol Synthesis by Cu-ZSM-5 (2010)

The reactive oxidizing species in the selective oxidation of methane to methanol in oxygen activated Cu-ZSM-5 was recently defined to be a bent mono(μ-oxo)dicopper(II) species, [Cu(2)O](2+). In this communication we report the formation of an O(2)-precursor of this reactive site with an associated absorption band at 29,000 cm(-1). Laser excitation into this absorption feature yields a resonance Raman (rR) spectrum characterized by (18)O(2) isotope sensitive and insensitive vibrations, νO-O and νCu-Cu, at 736 (Δ(18)O(2) = 41 cm(-1)) and 269 cm(-1), respectively. These define the precursor to be a μ-(η(2):η(2)) peroxo dicopper(II) species, [Cu(2)(O(2))](2+). rR experiments in combination with UV-vis absorption data show that this [Cu(2)(O(2))](2+) species transforms directly into the [Cu(2)O](2+) reactive site. Spectator Cu(+) sites in the zeolite ion-exchange sites provide the two electrons required to break the peroxo bond in the precursor. O(2)-TPD experiments with (18)O(2) show the incorporation of the second (18)O atom into the zeolite lattice in the transformation of [Cu(2)(O(2))](2+) into [Cu(2)O](2+). This study defines the mechanism of oxo-active site formation in Cu-ZSM-5.