gebhart/patrepeval huggingface dataset:
Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme. (1992)

Acylpeptide hydrolase may be involved in N-terminal deacetylation of nascent polypeptide chains and of bioactive peptides. The activity of this enzyme from human erythrocytes is sensitive to anions such as chloride, nitrate, and fluoride. Furthermore, blocked amino acids act as competitive inhibitors of the enzyme. Acetyl leucine chloromethyl ketone has been employed to identify one active site residue as His-707. Diisopropylfluorophosphate has been used to identify a second active site residue as Ser-587. Chemical modification studies with a water-soluble carbodiimide implicate a carboxyl group in catalytic activity. These results and the sequence around these active site residues, especially near Ser-587, suggest that acylpeptide hydrolase contains a catalytic triad. The presence of a cysteine residue in the vicinity of the active site is suggested by the inactivation of the enzyme by sulfhydryl-modifying agents and also by a low amount of modification by the peptide chloromethyl ketone inhibitor. Ebelactone A, an inhibitor of the formyl aminopeptidase, the bacterial counterpart of eukaryotic acylpeptide hydrolase, was found to be an effective inhibitor of this enzyme. These findings suggest that acylpeptidase hydrolase is a member of a family of enzymes with extremely diverse functions.
Structure and properties of silica nanoclusters at high temperatures (2002)

The properties of silica clusters at temperatures from 1500 to 2800 K are investigated using classical molecular dynamics simulations for particles containing up to 1152 atoms. We found that atoms in the cluster were arranged in a shell-like structure at low temperatures, and that the radial density profile peaked near the outer edge of the particle. Smaller clusters have much higher pressures, with the magnitudes corresponding quite well to those obtained from the Laplace--Young equation, when evaluated in a self-consistent manner using our derived surface tension. Our computed surface tension did not show any significant size-dependent behavior in contrast to the decreasing surface tension observed for Lennard--Jones liquid clusters. Finally our computed diffusion coefficients in the liquid state are seen to be larger than bulk computed diffusivities. A discussion regarding the relevance of these computations on the growth of silica nanoparticles is presented.
P450arom gene expression in peripheral blood lymphocytes: Identification of a cryptic splice site for exon-1 afterEpstein–Barr virus transformation (1998)

The human aromatase gene (P450arom) is widely expressed, albeit in a tissue-specific manner. In the present study, we measured aromatase activity and investigated the transcribed and translated products of the P450arom gene before and after Epstein-Barr virus (EBV) transformation in peripheral blood lymphocytes (PBLs) from normal individuals. Aromatase activity was determined by [3H]-delta4-androstenedione (A) to [3H]-estrone (E1) conversion. Cellular total RNA and protein lysates were subjected to RT-PCR and Western analysis, respectively. Rapid amplification of cDNA ends (RACE) was used for the detection of novel 5'-untranslated ends of the P450arom mRNA, which were subsequently sequenced and compared to the known transcripts of this gene. In untransformed PBLs, two known variants of exon 1 of the P450arom gene were expressed, corresponding to promoters PI.3 and PII, or 1c and 1d, respectively. In EBV-transformed PBLs, a cryptic splice site was revealed and a new 5'-untranslated product was found. RNase protection assay confirmed that this splice variant is not a RACE artifact. The 53 K P450arom protein was detectable in PBLs both before and after EBV transformation. We conclude that (i) the P450arom mRNA is present in human PBLs and (ii) EBV transformation of the latter leads to novel alternative splicing of the 5' end of this gene.
CFD Analysis of Gear Windage Losses: Validation and Parametric Aerodynamic Studies (2011)

A computational fluid dynamics (CFD) method has been applied to gear configurations with and without shrouding. The goals of this work have been to validate the numerical and modeling approaches used for these applications and to develop physical understanding of the aerodynamics of gear windage loss. Several spur gear geometries are considered, for which experimental data are available. Various canonical shrouding configurations and free spinning (no shroud) cases are studied. Comparisons are made with experimental data from open literature, and data recently obtained in the NASA Glenn Research Center Gear Windage Test Facility, Cleveland, OH. The results show good agreement with the experiment. The parametric shroud configuration studies carried out in the Glenn experiments and the CFD analyses elucidate the physical mechanisms of windage losses as well as mitigation strategies due to shrouding and newly proposed tooth contour modifications.
23.5 A Sub-1V 810nW Capacitively-Biased BJT-Based Temperature Sensor with an Inaccuracy of ±0.15°C (3σ) from −55°C to 125°C (2023)

BJT-based temperature sensors are widely used because they can achieve excellent accuracy after 1-point calibration. However, they typically dissipate <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\mu \text{Ws}$</tex> of power and require supply voltages above 1V [1]. Although sensors based on DTMOSTs [2], [3], capacitively biased (CB) diodes and BJTs [4,5] have demonstrated sub-1V operation, this comes at the expense of accuracy. This paper presents a sub-1V CB BJT-based temperature sensor that achieves a 1-point-trimmed inaccuracy of 0.15°C (3σ) from <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$-55^{\circ}\mathrm{C}$</tex> to <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$125^{\circ}\mathrm{C}$</tex> , which is <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$4\times$</tex> better than the CB BJT state-of-the-art [4]. It also achieves a resolution FoM of 0.34pJ.K <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , which is 6.8 <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\times$</tex> better than that of state-of-the-art BJT-based sensors with a similar accuracy [1], [6], (Fig. 23.5.6).
Generation of ultrabright tunable polarization entanglement without spatial, spectral, or temporal constraints (2004)

The need for spatial and spectral filtering in the generation of polarization entanglement is eliminated by combining two coherently driven type-II spontaneous parametric down-converters. The resulting ultrabright source emits photon pairs that are polarization entangled over the entire spatial cone and spectrum of emission. We detect a flux of $\ensuremath{\sim}12 000$ polarization-entangled pairs/s per mW of pump power at $90%$ quantum-interference visibility, and the source can be temperature tuned for $5\phantom{\rule{0.3em}{0ex}}\text{nm}$ around frequency degeneracy. The output state is actively controlled by precisely adjusting the relative phase of the two coherent pumps.
SUMOylation of the Corepressor N-CoR Modulates Its Capacity to Repress Transcription (2006)

In the absence of ligands the corepressor N-CoR mediates transcriptional repression by some nuclear hormone receptors. Several protein-protein interactions of N-CoR are known, of which mainly complex formation with histone deacetylases (HDACs) leads to the repression of target genes. On the other hand, the role of posttranslational modifications in corepressor function is not well established. Here, we show that N-CoR is modified by Sumo-1. We found SUMO-E2-conjugating enzyme Ubc9 and SUMO-E3 ligase Pias1 as novel N-CoR interaction partners. The SANT1 domain of N-CoR was found to mediate this interaction. We show that K152, K1117, and K1330 of N-CoR can be conjugated to SUMO and that mutation of all sites is necessary to fully block SUMOylation in vitro. Because these lysine residues are located within repression domains I and III, respectively, we investigated a possible correlation between the functions of the repression domains and SUMOylation. Coexpression of Ubc9 protein resulted in enhanced N-CoR-dependent transcriptional repression. Studies using SUMOylation-deficient N-CoR RDI mutants suggest that SUMO modification contributes to repression by N-CoR. Mutation of K152 to R in RD1, for example, not only significantly reduced repression of a reporter gene, but also abolished the effect of Ubc9 on transcriptional repression.
Future perspectives in melanoma research. Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6 th -7 th 2010" (2011)

Progress in understanding the molecular basis of melanoma has made possible the identification of molecular targets with important implications in clinical practice. In fact, new therapeutic approaches are emerging from basic science and it will be important to implement their rapid translation into clinical practice by active clinical investigation. The first meeting of Melanoma Research: a bridge Naples-USA, organized by Paolo A. Ascierto (INT, Naples, Italy) and Francesco Marincola (NIH, Bethesda, USA) took place in Naples, on 6-7 December 2010. This international congress gathered more than 30 international and Italian faculty members and was focused on recent advances in melanoma molecular biology, immunology and therapy, and created an interactive discussion across Institutions belonging to Government, Academy and Pharmaceutical Industry, in order to stimulate new approaches in basic, translational and clinical research. Four topics of discussion were identified: New pathways in Melanoma, Biomarkers, Clinical Trials and New Molecules and Strategies.
Green Efficient Frontiers: Practical Considerations in Constructing Sustainability Portfolios (2023)

As asset owners transition to sustainable investing, many seek portfolios with low tracking error to the core benchmarks they are replacing. Multiple considerations must be made when constructing such portfolios. The trade-off between tracking error, sustainability goals, and industry exposure, for example, must be managed. The authors illustrate the trade-offs across these three dimensions for a variety of sustainability metrics. In addition, sustainability portfolios may use one metric in the construction of the portfolio but may be judged on other metrics. The authors show that a portfolio optimized for one metric generally has favorable active exposure to other sustainability metrics, although less than that predicted by the linear relationship between the metrics. They also show that if a secondary metric is considered in the optimization objective, that metric has more favorable active exposure to the metric than that predicted by the linear relationship with the primary metric. The authors show that despite the low correlation across metrics, constructing portfolios with favorable active exposure to multiple sustainability metrics is possible and may yield disproportional benefits.
Supplementary Figures and Tables from A TLR3 Ligand Reestablishes Chemotherapeutic Responses in the Context of FPR1 Deficiency (2023)

&lt;p&gt;Supplementary Figures and Tables&lt;/p&gt;
Research Center for Quantitative Renal Imaging (2016)

is to provide a focused research environment and resource for the development, implementation, and dissemination of innovative, quantitative imaging methods designed to assess the status of and mechanisms associated with acute and chronic kidney disease and evaluate efficacy of therapeutic interventions. Nature of the Center:This Research Center provides a formal mechanism to link research programs focused on understanding the fundamental mechanisms associated with kidney diseases with those associated with the development of advanced imaging methods and quantitative analyses into a focused effort dedicated toward the development and implementation of quantitative renal imaging methods.
Data from 2-(3-{1-Carboxy-5-[(6-[<sup>18</sup>F]Fluoro-Pyridine-3-Carbonyl)-Amino]-Pentyl}-Ureido)-Pentanedioic Acid, [<sup>18</sup>F]DCFPyL, a PSMA-Based PET Imaging Agent for Prostate Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; We have synthesized and evaluated &lt;i&gt;in vivo&lt;/i&gt; 2-(3-{1-carboxy-5-[(6-[&lt;sup&gt;18&lt;/sup&gt;F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [&lt;sup&gt;18&lt;/sup&gt;F]DCFPyL, as a potential imaging agent for the prostate-specific membrane antigen (PSMA). PSMA is upregulated in prostate cancer epithelia and in the neovasculature of most solid tumors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; [&lt;sup&gt;18&lt;/sup&gt;F]DCFPyL was synthesized in two steps from the &lt;i&gt;p&lt;/i&gt;-methoxybenzyl (PMB) protected lys-C(O)-glu urea precursor using 6-[&lt;sup&gt;18&lt;/sup&gt;F]fluoronicotinic acid tetrafluorophenyl ester ([&lt;sup&gt;18&lt;/sup&gt;F]F-Py-TFP) for introduction of &lt;sup&gt;18&lt;/sup&gt;F. Radiochemical synthesis was followed by biodistribution and imaging with PET in immunocompromised mice using isogenic PSMA PC3 PIP and PSMA- PC3 flu xenograft models. Human radiation dosimetry estimates were calculated using OLINDA/EXM 1.0.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; DCFPyL displays a &lt;i&gt;K&lt;/i&gt;&lt;sub&gt;i&lt;/sub&gt; value of 1.1 ± 0.1 nmol/L for PSMA. [&lt;sup&gt;18&lt;/sup&gt;F]DCFPyL was produced in radiochemical yields of 36%–53% (decay corrected) and specific radioactivities of 340–480 Ci/mmol (12.6–17.8 GBq/μmol, &lt;i&gt;n&lt;/i&gt; = 3). In an immunocompromised mouse model [&lt;sup&gt;18&lt;/sup&gt;F]DCFPyL clearly delineated PSMA+ PC3 PIP prostate tumor xenografts on imaging with PET. At 2 hours postinjection, 39.4 ± 5.4 percent injected dose per gram of tissue (%ID/g) was evident within the PSMA+ PC3 PIP tumor, with a ratio of 358:1 of uptake within PSMA+ PC3 PIP to PSMA− PC3 flu tumor placed in the opposite flank. At or after 1 hour postinjection, minimal nontarget tissue uptake of [&lt;sup&gt;18&lt;/sup&gt;F]DCFPyL was observed. The bladder wall is the dose-limiting organ.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; These data suggest [&lt;sup&gt;18&lt;/sup&gt;F]DCFPyL as a viable, new positron-emitting imaging agent for PSMA-expressing tissues. &lt;i&gt;Clin Cancer Res; 17(24); 7645–53. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Performance Analysis of TOA Range Accuracy Adaptation for Cognitive Radio Systems (2009)

Location awareness is a prominent feature of cognitive radio (CR) systems. In order to support goal driven and autonomous location aware applications using CR systems, range accuracy adaptation is an essential task. Therefore, in this paper, performance analysis of optimal maximum likelihood (ML) time of arrival (TOA) range accuracy adaptation technique is conducted to study performance limits of location aware systems. The performance of ML-TOA range accuracy adaptation method is evaluated in dynamic spectrum access environments through computer simulations. The results show that range accuracy adaptation can be achieved by ML-TOA method with a relative error for each desired range accuracy.
"Sign in with ... Privacy'': Timely Disclosure of Privacy Differences among Web SSO Login Options (2022)

The number of login options on web sites has increased since the introduction of web single sign-on (SSO) protocols. Web SSO services allow users to grant web sites or relying parties (RPs) access to their personal profile information from identity provider (IdP) accounts. Many RP sites fail to provide sufficient privacy-related information to allow users to make informed login decisions. Moreover, privacy differences in permission requests across login options are largely hidden from users and are time-consuming to manually extract and compare. In this paper, we present an empirical analysis of popular RP implementations supporting three major IdP login options (Facebook, Google, and Apple) and categorize RPs in the top 500 sites into four client-side code patterns. Informed by these RP patterns, we design and implement SSOPrivateEye (SPEye), a browser extension prototype that extracts and displays to users permission request information from SSO login options in RPs covering the three IdPs.
Unsupervised Monocular Depth Learning in Dynamic Scenes (2020)

We present a method for jointly training the estimation of depth, ego-motion, and a dense 3D translation field of objects relative to the scene, with monocular photometric consistency being the sole source of supervision. We show that this apparently heavily underdetermined problem can be regularized by imposing the following prior knowledge about 3D translation fields: they are sparse, since most of the scene is static, and they tend to be constant for rigid moving objects. We show that this regularization alone is sufficient to train monocular depth prediction models that exceed the accuracy achieved in prior work for dynamic scenes, including methods that require semantic input. Code is at https://github.com/google-research/google-research/tree/master/depth_and_motion_learning .
Flexible Biradicals in Liquid and Supercritical Carbon Dioxide:  The Exchange Interaction, the Chain Dynamics, and a Comparison with Conventional Solvents (2006)

X-band time-resolved electron paramagnetic resonance (TREPR) spectra of three flexible biradicals of varying chain length and structure were obtained in liquid and supercritical carbon dioxide (CO2) solutions and compared to conventional solvents. For C16 acyl-alkyl biradical 1a, an average spin exchange interaction between the radical centers, J(avg), was obtained by spectral simulation using a simple model for spin-correlated radical pairs (SCRPs) and a small amount of T2 relaxation from a previously established J modulation mechanism. A large solvent effect on J(avg) was observed for the first time, varying by almost 1 order of magnitude from CO2 (J(avg) = -120 +/- 10 MHz) to heavy mineral oil (-11 +/- 3 MHz) for 1a. For C15 bis(alkyl) biradical 1b, spectra obtained under supercritical conditions are only slightly different from those detected in liquid CO2 but differ from spectra taken in benzene. For C10 acyl-alkyl biradical 2a, more emissive spin polarization due to S-T- mixing is observed in CO2 than in benzene. These results are discussed in terms of solvent properties such as dielectric constant, viscosity, and specific interactions. Both chain dynamics and changes to the equilibrium distribution of end-to-end distances can alter J(avg) and the observed ratio of S-T0 to S-T- mixing; however, faster chain dynamics is concluded to be the most likely cause of the observed effects in these systems.
Welcome from the TPC chairs (2011)

Welcome to the cyberspace for the 2011 IEEE Online Conference on Green Communications (GREENCOM'11), the first IEEE Communications Society (COMSOC) conference to be conducted entirely online.
TLS‐CHOP target gene DOL54 expression in liposarcomas and malignant fibrous histiocytomas (2002)

Downstream of the gene for the liposarcoma-associated fusion oncoprotein 54 (DOL54) is a target gene of the myxoid liposarcoma and round cell liposarcoma (M-LPS/RC-LPS) oncogene, TLS/FUS-CHOP. The DOL54 gene product is closely associated with adipogenic differentiation. DOL54 overexpression resulted in tumorigenicity when Chinese Hamster Ovary (CHO) cells were injected subcutaneously into nude mice. The biological significance of DOL54 expression for human malignant soft tissue tumors, however, has not yet been investigated. We examined TLS-CHOP and DOL54 expression in M-LPS/RC-LPS, well-differentiated liposarcoma and malignant fibrous histiocytoma (MFH), a tumor whose cellular origin has not been determined. We observed DOL54 expression in 50% of M-LPS/RC-LPS cases (in which TLS-CHOP was also expressed) and 33% of MFH cases, suggesting that a portion of MFH lesions may either derive from adipocytic precursor cells or have the potential to undergo adipogenic differentiation. In this manner, M-LPS/RC-LPS and MFH lesions may share tumorigenic characteristics, resulting from the unscheduled expression of DOL54.
Volumetric differences of thalamic nuclei in children with trisomy 21 (2023)

In this exploratory volumetric analysis of the thalamus and thalamic nuclei, we observed statistically significant volumetric changes in children with DS. Our findings confirm prior neuroimaging and histological studies and extend the range of involved thalamic nuclei in pediatric DS.
Electro-optic spatial light modulator characterization using Mueller matrix imaging (1997)

A series of electro-optic spatial light modulators have been measured with the Mueller matrix imaging polarimeter (MMIP). The MMIP is a dual rotating-retarder polarimeter which illuminates a sample with calibrated polarized states and analytes the existing polarized state over a spatially resolved image of the sample. Images of the retardance magnitude and retardance fast axis orientation reveal the relative electric field strengths in a device with lead- lanthanum-zirconate-titanate modulating material. By measuring Mueller matrix images of the device at several different applied voltages, a quadratic electro-optic coefficient of 2 X 10<SUP>-16</SUP> (m/V)<SUP>2</SUP> was determined in the modulator active regions.
Bone-Shaped Nanomaterials for Nanocomposite Applications (2003)

A novel template synthesis of bone-shaped (dumbbell-shaped, dogbone-shaped) nanomaterials is demonstrated. Porous anodic alumina (PAA) templates with uniform nanochannels were fabricated using a four-step anodization process and used to form bone-shaped carbon nanostructures with stem and end diameters and lengths of 40 nm, 70 nm, and 5 μm, respectively. These nanomaterials, which we refer to as bone-shaped T-CNTs (templated carbon nanotubes), have potential application in nanocomposites, where improved strength and toughness through mechanical interlocking is anticipated.
An on-chip partial drop wavelength selective broadcast network (2014)

A wavelength selective 1-by-8-port optical broadcasting system is proposed and demonstrated utilizing partial drop adiabatic microring tunable filters, achieving a 92.7GHz filter bandwidth, 36.2nm Free-Spectral-Range, low power-variation (0.11dB), and aggregate excess loss of only 1.1dB.
Recent progress in nanoparticle photoresists development for EUV lithography (2016)

Extreme ultraviolet (EUV) lithography is a promising candidate for next generation lithography. For high volume manufacturing of semiconductor devices, significant improvement of resolution and sensitivity is required for successful implementation of EUV resists. Performance requirements for such resists demand the development of entirely new resist platforms. Cornell University has intensely studied metal oxide nanoparticle photoresists with high sensitivity for EUV lithography applications. Zirconium oxide nanoparticles with PAG enabling sub 30nm line negative tone patterns at an EUV dose below 5 mJ/cm<sup>2</sup> show one of the best EUV sensitivity results ever reported. In this paper, recent progress in metal oxide nanoparticle photoresist research will be discussed. Several studies regarding composition investigation and new metal element study are reported.