gebhart/patrepeval huggingface dataset:
IgG Subclass Deficiencies (1986)

IgG subclasses differ not only in their biochemical and biologic properties, but also in their occurrence as selective deficiencies, alone and in combination. The normal range of IgG subclass concentrations in children and adults is compared with deficiencies found in individuals with repeated respiratory tract infections. Concomitant IgA deficiency is often noted. It is suggested that decreased IgG2 and IgG3 levels in IgA-deficient individuals may increase the risk of recurrent respiratory infection and lung damage. Finally, the efficacy immunoglobulin. prophylaxis in reducing of infection is anecdotally related.
Hybrid Bandpass-Absorptive-Bandstop Magnetically Coupled Acoustic-Wave-Lumped-Element-Resonator Filters (2018)

This letter presents a novel advancement in acoustic-wave-lumped-element-resonator (AWLR) filters, which improves transmission zero isolation by over 40 dB without adding any additional components. By spacing and orienting the AWLR-lumped inductors for intentional magnetic coupling, a hybrid bandpass-absorptive-bandstop filter is generated. The filter is demonstrated in three configurations using aluminum nitride contour-mode resonators and off-the-shelf lumped elements. Measured performance of as low as 3.2-dB insertion loss, bandwidth of 0.87%, and transmission zero notch depth greater than 60 dB is shown.
Dopamine D2Partial Agonists – Discovery, Evolution, and Therapeutic Potential (2019)

This chapter focuses on the medicinal chemistry of dopamine D2 partial agonists that have been approved for use in humans. The realization of the "dopamine hypothesis of schizophrenia" in the 1970s led to the first effective treatment for psychotic symptoms through pharmacological modulation with dopamine D2 receptor antagonists, albeit with the on-target risk of extrapyramidal effects and, potentially, tardive dyskinesia. This breakthrough was followed by a greater knowledge of dopamine and its receptor subtypes and the realization that these receptors, especially the dopamine D2 and dopamine D3 receptors, play a role in the pathophysiology of other conditions, including schizophrenia, Parkinson's disease, addiction, depression and mania, as well as attention and eating disorders. It was the paradoxical nature of schizophrenia as well as the desire to identify effective antipsychotics with reduced extrapyramidal symptoms that ultimately led to the search for dopamine D2 receptor partial agonists, biased ligands, and agents with selectivity for other dopamine receptor subtypes.
Bandwidth Enhancement of Single-Layer Microstrip Reflectarrays with Multi-Dipole Elements (2019)

The gain bandwidth limit of a single-layer microstrip reflectarray is analyzed using multi-dipole elements. By observing the reflection phase characteristics of the multi-dipole elements with different numbers of dipoles, it is shown how the bandwidth can be enhanced by increasing the number of element resonant structures. The fundamental limit of the bandwidth enhancement is then derived by analyzing the coupling between the surface wave and the incident plane wave. It is shown that the surface wave can be excited even with the plane wave of normal incidence on the reflectarray and that the excitation frequency of the surface wave is dominated by array parameters and is almost independent of the number of resonant structures. The degradation of the element reflection characteristics caused by the surface wave, which limits the reflectarray bandwidth, is investigated. By comparing the radiation characteristics of three reflectarrays with three-, five-, and seven-dipole element, respectively, the analysis of the bandwidth enhancement and its limit is verified. The measured 1-dB gain bandwidth of the three-dipole element reflectarray is 25.12%, and the bandwidth is enhanced to 33.52% with the five-dipole element. However, because of the surface wave, no further bandwidth enhancement is achieved when the seven-dipole element is used, as predicted.
Precoded Multirank Transmission with Linear Receivers for LTE-A Uplink (2009)

The 3rd generation partnership project (3GPP) defined the requirements for the upcoming long term evolution advanced (LTE-A) systems, aiming at peak spectral efficiencies of 30 bit/s/Hz in the downlink and 15 bits/s/Hz in the uplink. These ambitious targets can be accomplished only by using advanced multiple input multiple output (MIMO) antenna techniques. In this paper, we evaluate closed loop precoded multirank transmission for single carrier frequency division multiplexing (SC-FDM) as selected uplink modulation scheme by using the precoding codebook defined for LTE downlink. Its performance is compared with orthogonal frequency division multiplexing (OFDM). Results show that OFDM outperforms SC-FDM for medium-high ranks, but the gap can be reduced by adding further diversity branches. While narrowband precoding shows considerable gain over open loop transmission for all ranks, wideband precoding works with a very small feedback overhead but results to be a valid option mainly for low-rank transmission, where the low peak-to-average power ratio (PAPR) of SC-FDM signals is also preserved.
Exome sequencing identifies three novel AD‐associated genes (2020)

Abstract Background With the development of next‐generation sequencing technologies, it is possible to identify rare genetic variants that influence the risk of complex disorders. To date, whole exome sequencing (WES) strategies have shown that specific clusters of damaging rare variants in the TREM2 , SORL1 and ABCA7 genes are associated with an increased risk of developing Alzheimer’s Disease (AD), reaching odds ratios comparable with the main AD genetic risk factor, the APOE‐ε4 allele. Here, we set out to identify additional AD‐associated genes by a genome‐wide investigation of the burden of rare damaging variants in the genomes of AD cases and cognitively healthy controls, the largest AD‐WES dataset available worldwide. Method We integrated the data from 25,982 cases and controls from the European ADES consortium and ADSP consortium from the USA on a single server. We developed a unique bioinformatic pipeline that applies new techniques to homogenize and analyze these data. Carriers of pathogenic variants in genes associated with Mendelian inheritance of AD were excluded. After quality control, we used 12,652 AD cases and 8,693 controls for analysis. Genes were analyzed using a burden analysis, using both non‐synonymous and loss‐of‐function rare variants. Variant impact was prioritized using REVEL. Result In our discovery phase, we confirmed and further substantiated that carriership of protein‐damaging genetic variants in TREM2 , SORL1 or ABCA7 is a major AD‐risk factor. High‐impact variants in these genes are mostly extremely rare and they are enriched in AD patients with early ages at onset. Furthermore, we identified three additional genes that were significantly associated with AD, in which we identified a similar relationship between very rare, high‐impact variants and an enrichment in AD patients with early ages at onset. We are currently replicating these associations and several additional suggestive findings in independent datasets. The final results will be presented. Conclusion Development of new homogenization methods has enabled the combined analysis of the largest AD‐WES dataset worldwide. With this, we were able to validate and expand on previous findings and to identify new genetic determinants of AD. Together, these genes pinpoint the most relevant pathways in the pathophysiological processes leading to AD.
Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer (2010)

Phosphorylated AMPK expression in colorectal cancer is associated with superior prognosis among p-MAPK3/1-positive cases, but not among p-MAPK3/1-negative cases, suggesting a possible interaction between the AMPK and MAPK pathways influencing tumour behaviour.
Analysis of pin fins with radiation (2017)

Papers presented at the 13th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Portoroz, Slovenia on 17-19 July 2017 .
Brain cross‐protection against SARS‐CoV‐2 variants by a lentiviral vaccine in new transgenic mice (2021)

COVID-19 vaccines already in use or in clinical development may have reduced efficacy against emerging SARS-CoV-2 variants. In addition, although the neurotropism of SARS-CoV-2 is well established, the vaccine strategies currently developed have not taken into account protection of the central nervous system. Here, we generated a transgenic mouse strain expressing the human angiotensin-converting enzyme 2, and displaying unprecedented brain permissiveness to SARS-CoV-2 replication, in addition to high permissiveness levels in the lung. Using this stringent transgenic model, we demonstrated that a non-integrative lentiviral vector, encoding for the spike glycoprotein of the ancestral SARS-CoV-2, used in intramuscular prime and intranasal boost elicits sterilizing protection of lung and brain against both the ancestral virus, and the Gamma (P.1) variant of concern, which carries multiple vaccine escape mutations. Beyond induction of strong neutralizing antibodies, the mechanism underlying this broad protection spectrum involves a robust protective T-cell immunity, unaffected by the recent mutations accumulated in the emerging SARS-CoV-2 variants.
Testis/sperm-specific histone 2B in the sperm of donors and subfertile patients: variability and relation to chromatin packaging (2006)

CMA3 positive staining of TSH2B-containing individual spermatozoa and a significant correlation between the total TSH2B level and CMA3 percentage in semen samples suggest a structural role for TSH2B in sperm chromatin organization. Low variability of TSH2B level in donors implies a mechanism (however unknown) regulating this parameter.
Development of a scanner-specific simulation framework for photon-counting computed tomography (2019)

The aim of this study was to develop and validate a simulation platform that generates photon-counting CT images of voxelized phantoms with detailed modeling of manufacturer-specific components including the geometry and physics of the x-ray source, source filtrations, anti-scatter grids, and photon-counting detectors. The simulator generates projection images accounting for both primary and scattered photons using a computational phantom, scanner configuration, and imaging settings. Beam hardening artifacts are corrected using a spectrum and threshold dependent water correction algorithm. Physical and computational versions of a clinical phantom (ACR) were used for validation purposes. The physical phantom was imaged using a research prototype photon-counting CT (Siemens Healthcare) with standard (macro) mode, at four dose levels and with two energy thresholds. The computational phantom was imaged with the developed simulator with the same parameters and settings used in the actual acquisition. Images from both the real and simulated acquisitions were reconstructed using a reconstruction software (FreeCT). Primary image quality metrics such as noise magnitude, noise ratio, noise correlation coefficients, noise power spectrum, CT number, in-plane modulation transfer function, and slice sensitivity profiles were extracted from both real and simulated data and compared. The simulator was further evaluated for imaging contrast materials (bismuth, iodine, and gadolinium) at three concentration levels and six energy thresholds. Qualitatively, the simulated images showed similar appearance to the real ones. Quantitatively, the average relative error in image quality measurements were all less than 4% across all the measurements. The developed simulator will enable systematic optimization and evaluation of the emerging photon-counting computed tomography technology.
HMOX1 is an Important Prognostic Indicator of Nonmuscle Invasive Bladder Cancer Recurrence and Progression (2010)

Analysis of HMOX1 expression in 211 NMIBC tissue specimens revealed its potential usefulness as a marker to predict the NMIBC prognosis.
Expanding the Boundaries: Developing a Streamlined Tool for Eco-Footprinting of Pharmaceuticals (2013)

The American Chemical Society Green Chemistry Institute Pharmaceutical Roundtable has utilized process mass intensity (PMI) as the key high-level metric to evaluate and benchmark progress towards more sustainable manufacturing. The long-term aim is to move towards metrics based on life cycle assessment (LCA) methodologies. This paper describes the development of a streamlined PMI and LCA tool intended to be used as the standard early assessment of synthetic routes for active pharmaceutical ingredients (API) and fine chemicals, especially during the route development stages when life cycle inventory data are often not readily available.
Copper‐Catalyzed Regioselective ortho CH Cyanation of Vinylarenes (2014)

A copper-based catalytic technique for the regioselective ortho C-H cyanation of vinylarenes has been developed. This method provides an effective means for the selective functionalization of vinylarene derivatives. A copper-catalyzed cyanative dearomatization mechanism is proposed to account for the regiochemical course of this reaction.
Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity (2021)

Abstract Blood samples are frequently collected in human studies of the immune system but poorly represent tissue-resident immunity. Understanding the immunopathogenesis of tissue-restricted diseases, such as chronic hepatitis B, necessitates direct investigation of local immune responses. We developed a workflow that enables frequent, minimally invasive collection of liver fine-needle aspirates in multi-site international studies and centralized single-cell RNA sequencing data generation using the Seq-Well S 3 picowell-based technology. All immunological cell types were captured, including liver macrophages, and showed distinct compartmentalization and transcriptional profiles, providing a systematic assessment of the capabilities and limitations of peripheral blood samples when investigating tissue-restricted diseases. The ability to electively sample the liver of chronic viral hepatitis patients and generate high-resolution data will enable multi-site clinical studies to power fundamental and therapeutic discovery.
Data pre-conditioning for improved performance of the prony method (1989)

A method is described which mitigates the degradation in accuracy experienced by the Prony singular value decomposition method when applied to low signal-to-noise ratio signals. This is a data pre-conditioning technique which utilizes the fast Fourier transform in conjunction with filtering to room-in on a portion of the signal specmm thus, concentrating all of the poles on the region of interest. The improvement in performance is illustrated using a data set containing several lines imbedded within a challenging noise level.
Active fiber-ring enhanced absorption gas spectroscopy using multi-longitudinal mode tunable laser in the NIR (2019)

In this work, we report the usage of multi-longitudinal mode laser as an input source to achieve a larger enhancement in the interaction length in cavity enhanced absorption spectroscopy. The MM laser source is constructed in the form of a ring laser using a long fiber coil, a directional coupler, a tunable filter with FWHM of 1 nm and a semiconductor optical amplifier pumped above the laser threshold. The ring has a length of about 1004 m with an FSR of 199.2 kHz. The gas cell is inserted into another ring cavity, which consists of two directional couplers and a gain medium pumped below threshold. The gain medium is used to compensate for the losses and boost the ring cavity finesse. The cavity ring has a length of about 6 m which gives an FSR of 33.3 MHz. The large ratio between the lengths of the two cavities (the MM laser cavity and the gas cell ring cavity) eliminates the need for a mode-locked technique. The acetylene gas cell is measured around 1535 nm. The interaction length is improved by a factor of about 37 compared to the direct absorption of the gas cell.
Evaluation of candidate monitoring technologies for multi-metal emissions from a U.S. DOE mixed waste incinerator (1998)

A field evaluation of three candidate monitoring techniques for multi-metal emissions from a mixed waste incinerator was performed at the US Department of Energy (DOE) Toxic Substances Control Act (TSCA) Incinerator located at the East Tennessee Technology Park in Oak Ridge, Tennessee. The test was designed to compare measurements of three multi-metals monitoring systems with EPA Reference Method 29 measurements to determine the relative performance of the monitoring systems at varying stack conditions and their deployment potential based on current status. The three monitoring systems were the Hazardous Element Sampling Train (HEST) developed by Cooper Environmental Services, the Trace-AIR on-line inductively coupled plasma (ICP) system from Thermo Jarrell Ash Corporation, and a laser induced breakdown spectrometer (LIBS) based system from Sandia National Laboratories.
Observation of high enantioselectivity for the gas phase hydrogenation of methyl pyruvate using supported Pt catalysts pre-modified with cinchonidineElectronic supplementary information (ESI) available: use of the Kelvin equation and reactant partial pressure to estimate the effective partial pressure for condensation as a function of pore radius. See http://www.rsc.org/suppdata/cc/b3/b304976k/ (2003)

Pt supported on alpha-Al2O3, gamma-Al2O3 and SiO2 pre-modified with cinchonidine gives over 50% ee in the hydrogenation of methyl pyruvate to methyl lactate using gas phase reactants at 40 degrees C giving the first clear observation of high enantioselection at the gas/solid interface.
Free radicals upregulate complement expression in rabbit isolated heart (2000)

Both free radicals and complement activation can injure tissue. Our study determined whether free radicals alter complement production by the myocardium. Isolated hearts from New Zealand White rabbits were perfused on a Langendorff apparatus and exposed to xanthine (X; 100 microM) plus xanthine oxidase (XO; 8 mU/ml) (X/XO). The free radical-generating system significantly (P < 0.05) increased C1q and also increased C1r, C3, C8, and C9 transcription compared with controls. Immunohistological examination revealed augmented membrane attack complex deposition on X/XO-treated tissue. X/XO-treated hearts also exhibited significant (P < 0.05) increases in coronary perfusion pressure and left ventricular end-diastolic pressure and a decrease in left-ventricular developed pressure. N-(2-mercaptopropionyl)-glycine (3 mM), in conjunction with the superoxide dismutase mimetic SC-52608 (100 microM), significantly (P < 0.05) reduced the upregulation of C1q, C1r, C3, C8, and C9 mRNA expression elicited by X/XO. The antioxidants also ameliorated the deterioration in function caused by X/XO. Local complement activation may represent a mechanism by which free radicals mediate tissue injury.
Prettier concurrency (2011)

This article presents an extension to the work of Launchbury and Peyton-Jones on the ST monad. Using a novel model for concurrency, called concurrent revisions [3,5], we show how we can use concurrency together with imperative mutable variables, while still being able to safely convert such computations (in the Rev monad) into pure values again.
The effect of the chemical nature of grafted chains on the interfacial miscibility of amphiphiles (2007)

This volume focuses on examining physical phenomena that occur in colloidal systems such as micellar solutions, microemulsions, emulsions, dispersions, slurries, etc. It principally concentrates on liquid/air, liquid/liquid, and liquid/solid interfaces. The work summarizes our current understanding of interfacial structure at the molecular level in these systems, and the relation of this structure to chemical and physico-chemical phenomena.
Letter From the Editors (2007)

DeVita, Vincent T. Jr, MD; Lawrence, Theodore S. MD, PhD; Rosenberg, Steven A. MD Author Information
Tachycardia‐Induced Right Ventricular Cardiomyopathy: Epicardial Radiofrequency Ablation of an Unusual and Unexpected Ventricular Tachycardia (2009)

A 38-year-old man without prior medical history was hospitalized for sustained monomorphic ventricular tachycardia (VT) left bundle branch block pattern with inferior QRS axis resistant to beta blockers. Right ventricular (RV) ejection fraction (EF) was 28%. Left ventricular EF was normal. Right and left endocardial ablation failed. Percutaneous epicardial radiofrequency application at the lateral mitral annulus was successful. The RVEF later normalized. Some VTs originating from the left ventricular epicardium are potential mimickers of benign VTs originating from the ventricular outflow tract (right or left) or arrhythmogenic right ventricular cardiomyopathy VT and they may induce isolated RV dysfunction.
ChemInform Abstract: Conversion of 1,3‐Thiazolidine and Its Sulfoxide to Dihydro‐1,4‐ thiazine. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Candidate Gene Approach Identifies Multiple Genes and Signaling Pathways Downstream of Tbx4 in the Developing Allantois (2012)

Loss of Tbx4 results in absence of chorio-allantoic fusion and failure of formation of the primary vascular plexus of the allantois leading to embryonic death at E10.5. We reviewed the literature for genes implicated in chorio-allantoic fusion, cavitation and vascular plexus formation, processes affected in Tbx4 mutant allantoises. Using this candidate gene approach, we identified a number of genes downstream of Tbx4 in the allantois including extracellular matrix molecules Vcan, Has2, and Itgα5, transcription factors Snai1 and Twist, and signaling molecules Bmp2, Bmp7, Notch2, Jag1 and Wnt2. In addition, we show that the canonical Wnt signaling pathway contributes to the vessel-forming potential of the allantois. Ex vivo, the Tbx4 mutant phenotype can be rescued using agonists of the Wnt signaling pathway and, in wildtype allantoises, an inhibitor of the canonical Wnt signaling pathway disrupts vascular plexus formation. In vivo, Tbx4 and Wnt2 double heterozygous placentas show decreased vasculature suggesting interactions between Tbx4 and the canonical Wnt signaling pathway in the process of allantois-derived blood vessel formation.
DNA‐Gold Triangular Nanoprism Conjugates (2008)

DNA-conjugated triangular gold nanoprisms are synthesized and characterized to determine the factors that allow adsorbtion of alkylthiol-modified oligonucleotides on different facets of an anisotropic gold nanoparticle (see image). Face-selective DNA-ligand adsorption processes are time-dependent and can be exploited to selectively immobilize DNA on the different edges and faces of the particle. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.