gebhart/patrepeval huggingface dataset:
Structure Elucidation of Sphingolipids from the Mycopathogen Paracoccidioides brasiliensis:  An Immunodominant β-Galactofuranose Residue Is Carried by a Novel Glycosylinositol Phosphorylceramide Antigen† (1998)

Two major acidic glycolipid components (Pb-1 and Pb-2) have been extracted from the mycopathogen Paracoccidioides brasiliensis, a thermally dimorphic fungus endemic to rural areas of South and Central America. Sera of all patients exhibiting paracoccidioidomycosis were found to be reactive with Pb-1, but not with Pb-2; no reactivity was observed with sera of healthy patients or those with histoplasmosis [Toledo, M. S., Suzuki, S., Straus, A. H., and Takahashi, H. K. (1995) J. Med. Vet. Mycol. 33, 247-251]. We report here the complete structure elucidation of both P. brasiliensis glycolipids using monosaccharide, fatty acid, sphingosine, and inositol component analysis by GC-MS; 1H- and 31P NMR spectroscopy; ESI-MS and -MS/CID-MS, linkage analysis, and exoglycosidase digestion. The compounds were found to be glycosylinositol phosphorylceramides (GIPCs) with the following structures: Pb-2, Manpalpha1-->3Manpalpha1-->2Ins1-P-1Cer; and Pb-1, Manpalpha1-->3[Galfbeta1-->6]Manpalpha1-->2Ins1- P-1Cer. The serologically nonreactive Pb-2 appears to be a biosynthetic intermediate between mannosylinositol phosphorylceramide (MIPC), which is widely distributed among fungi, and the antigenic Pb-1. Pb-1 is a novel glycosphingolipid, similar to a triglycosyl IPC (Hc-VI) reported from Histoplasma capsulatum [Barr, K., Laine, R.A, and Lester, R. L. (1984) Biochemistry 23, 5589-5596], but differing in the anomeric configuration of the terminal Galf1-->6 residue, which is immunodominant. The significance of these structures as serological and taxonomic markers, as well as their potential utility as targets for immunodiagnostic agents, is discussed.
Finite Element Analysis of Fabrication- and Operation-Induced Mechanical Stress in AlGaN/GaN Transistors (2016)

Mechanical stress is an important factor influencing the performance and reliability of GaN-based devices. In highly piezoelectric materials like AlGaN/GaN, mechanical stress directly influences the piezoelectric polarization, and hence the charge density of the 2-D electron gas. Fabrication processes for devices as well as device operating conditions can change the mechanical stress in AlGaN/GaN transistors. In this paper, the mechanical stress resulting from fabrication and operation of AlGaN/GaN transistors has been modeled using a finite element analysis approach. Specifically, the stress induced in AlGaN/GaN by chemical vapor deposition of silicon nitride films is discussed. Furthermore, the temperature-induced mechanical stress during on-state device operation is computed and the effect of source field plates and substrate materials has been investigated. Finally, the above-mentioned stress components are compared with those due to lattice mismatch, epi growth, and inverse piezoelectric effect. The potential impact of mechanical stress on device reliability is also discussed.
Charge-Neutral Ir(III) Metal Phosphors Bearing Functional Pyrazole–Pyridine–Pyrazole Chelates (2023)

Homoleptic charge-neutral Ir(III) metal complexes bearing tridentate chelates composed of two orthogonally aligned pyrazole–pyridine–pyrazole fragments were designed and synthesized. It is notable that the substituents play an essential role in tuning both the photophysical and electrochemical properties. Upon the introduction of CF3 substituents at the central pyridyl fragment of one tridentate chelate and peripheral pyrazolate fragments of alternative tridentate chelate, phosphorescence can be fine-tuned from green to orange, together with an improved emission quantum yield, as recorded in degassed tetrahydrofuran (THF) solution at room temperature (RT). Further replacement of the N–H fragment of monoanionic chelate with a methyl substituent gives Ir(III) complexes [Ir(Bpz2pyMe)(Fpz2py)] (2Me) and [Ir(Bpz2FpyMe)(Fpz2py)] (3Me), showing decomposition temperatures (Td) greater than 300 °C. Therefore, this work paves a new avenue for designing and synthesizing emissive Ir(III) complexes without the traditional cyclometalating aromatics, albeit with a lowered emission efficiency. As a proof of concept, Ir(III) complexes 2Me and 3Me were employed as the dopant emitters for organic light-emitting diode (OLED) fabrication, giving a maximum external quantum efficiency (EQE) of 7.1 and 15.9% and a current efficiency (CE) of 22.5 and 50 cd·A–1, respectively.
Computer graphics in rational anti-cancer drug design (1982)

Conference Article| December 01 1982 Computer graphics in rational anti-cancer drug design S. A. ISLAM; S. A. ISLAM *Cancer Research Campaign Biomolecular Structure Research Group, Department of Biophysics, King's College, 26–29 Drury Lane, London WC2B 5RL, U.K. Search for other works by this author on: This Site PubMed Google Scholar R. KURODA; R. KURODA *Cancer Research Campaign Biomolecular Structure Research Group, Department of Biophysics, King's College, 26–29 Drury Lane, London WC2B 5RL, U.K. Search for other works by this author on: This Site PubMed Google Scholar S. NEIDLE; S. NEIDLE *Cancer Research Campaign Biomolecular Structure Research Group, Department of Biophysics, King's College, 26–29 Drury Lane, London WC2B 5RL, U.K. Search for other works by this author on: This Site PubMed Google Scholar J. R. BROWN; J. R. BROWN †Department of Pharmaceutical Chemistry, Sunderland Polytechnic, Green Terrace, Sunderland SR1 3SD, U.K. Search for other works by this author on: This Site PubMed Google Scholar B. M. GANDECHA; B. M. GANDECHA ‡School of Pharmacy, Leicester Polytechnic, P.O. Box 143, Leicester. LE1 9BH, U.K. Search for other works by this author on: This Site PubMed Google Scholar L. H. PATTERSON L. H. PATTERSON ‡School of Pharmacy, Leicester Polytechnic, P.O. Box 143, Leicester. LE1 9BH, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1982) 10 (6): 501. https://doi.org/10.1042/bst0100501 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation S. A. ISLAM, R. KURODA, S. NEIDLE, J. R. BROWN, B. M. GANDECHA, L. H. PATTERSON; Computer graphics in rational anti-cancer drug design. Biochem Soc Trans 1 December 1982; 10 (6): 501. doi: https://doi.org/10.1042/bst0100501 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1982 Biochemical Society1982 Article PDF first page preview Close Modal You do not currently have access to this content.
SNP Genotyping Defines Complex Gene-Flow Boundaries Among African Malaria Vector Mosquitoes (2010)

Mosquitoes in the Anopheles gambiae complex show rapid ecological and behavioral diversification, traits that promote malaria transmission and complicate vector control efforts. A high-density, genome-wide mosquito SNP-genotyping array allowed mapping of genomic differentiation between populations and species that exhibit varying levels of reproductive isolation. Regions near centromeres or within polymorphic inversions exhibited the greatest genetic divergence, but divergence was also observed elsewhere in the genomes. Signals of natural selection within populations were overrepresented among genomic regions that are differentiated between populations, implying that differentiation is often driven by population-specific selective events. Complex genomic differentiation among speciating vector mosquito populations implies that tools for genome-wide monitoring of population structure will prove useful for the advancement of malaria eradication.
Conformity and communal decision-making: First-tester effects on acceptance of home-based HIV counseling and testing in Uganda (2018)

Background : Individuals’ observation of how group members ahead of them behave can profoundly shape their perceptions, judgements, and subsequent behaviors. Moreover, social influence theories from the sociology of networks suggest that individuals’ social status and social network position determine the scope of their influence on other group members. We set out to examine the role of conformity and communal decision-making in shaping individual decisions to test for HIV during home-based TB contact investigation in Kampala, Uganda. Methods: We analyzed the HIV testing decisions of individuals who were offered free, optional, home-based HIV testing during a home visit by community health workers. We used to generalized estimating equations (GEE) to estimate how the testing decision made by the first individual in a household offered testing influenced the subsequent testing decisions of other household members. Results: Community health workers visited 55 households with two or more eligible household members and offered 160 individuals HIV testing. Seventy-five (47%) declined the test. Individuals in households where the first person invited declined HIV testing had four times the risk of declining themselves (RR: 3.96, 95% CI: 1.7-9.0, p=0.001) compared to individuals in households where the first person invited agreed to HIV testing, controlling for individual age and gender. Conclusions : The decision of the first individual offered HIV testing seems to influence the decisions of subsequent household members when they are also offered testing. Even when results are confidential, individual decisions may be shaped by the testing behavior of the first household member offered the test.
Faster and Cheaper: Parallelizing Large-Scale Matrix Factorization on\n GPUs (2016)

Matrix factorization (MF) is employed by many popular algorithms, e.g.,\ncollaborative filtering. The emerging GPU technology, with massively multicore\nand high intra-chip memory bandwidth but limited memory capacity, presents an\nopportunity for accelerating MF much further when appropriately exploiting the\nGPU architectural characteristics.\n This paper presents cuMF, a CUDA-based matrix factorization library that\nimplements memory-optimized alternate least square (ALS) method to solve very\nlarge-scale MF. CuMF uses a variety set of techniques to maximize the\nperformance on either single or multiple GPUs. These techniques include smart\naccess of sparse data leveraging GPU memory hierarchy, using data parallelism\nin conjunction with model parallelism, minimizing the communication overhead\nbetween computing units, and utilizing a novel topology-aware parallel\nreduction scheme.\n With only a single machine with four Nvidia GPU cards, cuMF can be 6-10 times\nas fast, and 33-100 times as cost-efficient, compared with the state-of-art\ndistributed CPU solutions. Moreover, this cuMF can solve the largest matrix\nfactorization problem ever reported yet in current literature, while\nmaintaining impressively good performance.\n
Industrial solid waste based layered double hydroxide composite with enhanced adsorption affinity to Congo red, Acid red, and Reactive red (2023)

Abstract The synthesis of hierarchically porous materials from industrial solid waste as catalysts or adsorbents has attracted much attention in environmental pollution control. The present work highlights the synthesis of a series of MgFeAl layered double hydroxide (LDH) with different ratios of Mg/(Fe + Al) from red mud and ferronickel slag under different pH to decolorize three red dye solutions, namely, Congo red (CR), acid red (AR), and reactive red (RR). The maximum adsorption capacity (386.1 mg.g –1 ) for CR was obtained by the MgFeAl-LDH sample with Mg/(Fe + Al) mole ratio of 2 synthesized under pH 10. The optimized synthesis parameters led to a high surface area and large pore volume of MgFeAl-LDH, thereby enhancing the mass transfer of adsorbate to the active sites of the adsorbent. Further, the MgFeAl-LDH sample was also efficient in removing AR (120.9 mg.g –1 ) and RR (114 mg.g –1 ). Moreover, the adsorption kinetics and isotherms of MgFeAl-LDH fitted well with the pseudo-second-order and Langmuir models, respectively. The MgFeAl-LDH system developed a valuable approach to utilize industrial waste for dye removal.
The Southeast Asian Port and Polity: Rise and Demise. Edited by J. Kathirithamby-Wells and John Villiers. Singapore: Singapore University Press, 1990. xiii, 265 pp. $22.00 (paper). (1991)

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A Data-Driven Approach With Uncertainty Quantification for Predicting Future Capacities and Remaining Useful Life of Lithium-ion Battery (2020)

Predicting future capacities and remaining useful life (RUL) with uncertainty quantification is a key but challenging issue in the applications of battery health diagnosis and management. This article applies advanced machine-learning techniques to achieve effective future capacities and RUL prediction for lithium-ion (Li-ion) batteries with reliable uncertainty management. To be specific, after using the empirical mode decomposition (EMD) method, the original battery capacity data is decomposed into some intrinsic mode functions (IMFs) and a residual. Then, the long short-term memory (LSTM) submodel is applied to estimate the residual while the Gaussian process regression (GPR) submodel is utilized to fit the IMFs with the uncertainty level. Consequently, both the long-term dependence of capacity and uncertainty quantification caused by the capacity regenerations can be captured directly and simultaneously. Experimental aging data from different batteries are deployed to evaluate the performance of proposed LSTM+GPR model in comparison with the solo GPR, solo LSTM, GPR+EMD, and LSTM+EMD models. Illustrative results demonstrate the combined LSTM+GPR model outperforms other counterparts and is capable of achieving accurate results for both 1-step and multistep ahead capacity predictions. Even predicting the RUL at the early battery cycle stage, the proposed data-driven approach still presents good adaptability and reliable uncertainty quantification for battery health diagnosis.
Motorized fusion guided prostate biopsy: phantom study (2017)

Purpose: Fusion of Magnetic Resonance Imaging (MRI) with intraoperative real-time Ultrasound (US) during prostate biopsy has significantly improved the sensitivity of transrectal ultrasound (TRUS) guided cancer detection. Currently, sweeping of the TRUS probe to build a 3D volume as part of the fusion process and the TRUS probe manipulation for needle guidance are both done manually. A motorized, joystick controlled, probe holder was custom fabricated that can potentially reduce inter-operator variability, provide standardization of needle placement, improve repeatability and uniformity of needle placement, which may have impacts upon the learning curve after clinical deployment of this emerging approach. Method: a 2DOF motorized probe holder was designed to provide translation and rotation of a triplane TRUS end firing probe for prostate biopsy. The probe holder was joystick controlled and can assist manipulation of the probe during needle insertion as well as in acquiring a smoother US 2D to 3D sweep in which the 3D US volume for fusion is built. A commercial MRI-US fusion platform was used. Three targets were specified on MR image of a commercial prostate phantom. After performing the registration, two operators performed targeting, once manually and once with the assistance of the motorized probe holder. They repeated these tasks 5 times resulting in a total of 30 targeting events. Time of completion and mechanical error i.e. distance of the target from the needle trajectory in the software user interface were measured. Repeatability in reaching a given target in a systematic and consistent way was measured using a scatter plot showing all targets in the US coordinate system. Pearson product-moment correlation coefficient (PPMCC) was used to demonstrate the probe steadiness during targeting. Results: the completion time was 25&plusmn;17 sec, 25&plusmn;24 sec, and 27&plusmn;15 sec for free hand and 24&plusmn;10 sec, 22.5&plusmn;10 sec, and 37&plusmn;10 sec for motorized insertion, for target 1, 2, and 3, respectively. The mechanical error was 0.75&plusmn;0.4 mm, 0.45&plusmn;0.4 mm, and 0.55&plusmn;0.4 mm, for free hand approach while it was 1.0&plusmn;0.57 mm, 0.45&plusmn;0.4 mm, and 0.35&plusmn;0.25 mm, for motorized approach, for target 1, 2, and 3, respectively. PPMCC remained almost at 1.0 for the motorized approach while having a variation between 0.9 and 1.0 for the free hand approach. Conclusions: motorized fusion guided prostate biopsy in a phantom study was feasible and non-inferior or comparable to the free hand manual approach in terms of accuracy and speed of targeting, while being superior in terms of repeatability and steadiness.
p63 Transcriptional Regulation of Epithelial Integrity and Cancer (2007)

p63 plays a more complex role than initially thought in cancer and development. As a p53 homolog, p63 encodes transcription factors that primarily functions through regulation of downstream gene expression. However, p63 is also involved in RNA processing and activation of beta-catenin signaling. A number of genes activated by TAp63 support the notion that p63 is involved in tight transcriptional control of epithelial differentiation, cell adhesion, and tumorigenesis via cell cycle arrest, apoptosis, and other cellualr functions. In addition, DeltaNp63 isotypes retain a rather short transactivation domain and were found to transcriptionally regulate a specific set of downstream gene targets. We found that p63 is capable of activating gene expression through binding to specific cis-elements, RE1 and RE2, with the latter being more specific for p63 than for p53. Differences in p53 family members DNA binding may help to explain key differences in their function and biology.
Crystalline silicon solar cells with thin poly-SiO x carrier-selective passivating contacts for perovskite/c-Si tandem applications (2023)

Single junction crystalline silicon (c-Si) solar cells are reaching their practical efficiency limit while perovskite/c-Si tandem solar cells have achieved efficiencies above the theoretical limit of single junction c-Si solar cells. Next to low-thermal budget silicon heterojunction architecture, high-thermal budget carrier-selective passivating contacts (CSPCs) based on polycrystalline-SiO (poly-SiO ) also constitute a promising architecture for high efficiency perovskite/c-Si tandem solar cells. In this work, we present the development of c-Si bottom cells based on high-temperature poly-SiO CSPCs and demonstrate novel high-efficiency four-terminal (4T) and two-terminal (2T) perovskite/c-Si tandem solar cells. First, we tuned the ultra-thin, thermally grown SiO . Then we optimized the passivation properties of p-type and n-type doped poly-SiO CSPCs. Here, we have optimized the p-type doped poly-SiO CSPC on textured interfaces via a two-step annealing process. Finally, we integrated such bottom solar cells in both 4T and 2T tandems, achieving 28.1% and 23.2% conversion efficiency, respectively.
Re-pensando realidades: líneas transversales de los debates (2011)

una condicin transversal que estructura su forma y su objeto: la pluralidad.Nos enfrentamos a una pluralidad de voces, de perspectivas, de temticas y de cuestiones interrelacionadas.
Sensitivity inspector: Detecting privacy in smart energy applications (2014)

The problem of privacy disclosure hinders large number of ubiquitous applications to collect, disseminate and analyze personal data from providing useful and important services. It is understood that sharing private data has high potential for facilitating innumerable benefits as well as inviting intended or unintended malicious activities leading to severe privacy breach. Such privacy breach attacks mostly capture sensitive or broadly the anomalous events. Fine grained, high resolution smart meter energy consumption data contains sensitive house hold activity signature. In this paper, we propose a tool called `Sensitivity Inspector' that detects sensitivity in smart meter data and inculcates privacy awareness among smart meter users, presuming private events are related to anomalous or unusual activities. Specifically, we analyze the sensitive content of smart meter data through robust unsupervised statistical method considering user activity as a piece-wise, stationary, stochastic process with associated uncertainty. We show the efficacy of our scheme under relevant statistical and information theoretic measures. We implement our algorithm and compare sensitivity detection capability with related supervised learning based approach and relevant privacy breaching attack like Non-Intrusive Load Monitoring (NILM).
N-Cadherin and Keratinocyte Growth Factor Receptor Mediate the Functional Interplay between Ki-RASG12V and p53V143A in Promoting Pancreatic Cell Migration, Invasion, and Tissue Architecture Disruption (2006)

The genetic basis of pancreatic ductal adenocarcinoma, which constitutes the most common type of pancreatic malignancy, involves the sequential activation of oncogenes and inactivation of tumor suppressor genes. Among the pivotal genetic alterations are Ki-RAS oncogene activation and p53 tumor suppressor gene inactivation. We explain that the combination of these genetic events facilitates pancreatic carcinogenesis as revealed in novel three-dimensional cell (spheroid cyst) culture and in vivo subcutaneous and orthotopic xenotransplantation models. N-cadherin, a member of the classic cadherins important in the regulation of cell-cell adhesion, is induced in the presence of Ki-RAS mutation but subsequently downregulated with the acquisition of p53 mutation as revealed by gene microarrays and corroborated by reverse transcription-PCR and Western blotting. N-cadherin modulates the capacity of pancreatic ductal cells to migrate and invade, in part via complex formation with keratinocyte growth factor receptor and neural cell adhesion molecule and in part via interaction with p120-catenin. However, modulation of these complexes by Ki-RAS and p53 leads to enhanced cell migration and invasion. This preferentially induces the downstream effector AKT over mitogen-activated protein kinase to execute changes in cellular behavior. Thus, we are able to define molecules that in part are directly affected by Ki-RAS and p53 during pancreatic ductal carcinogenesis, and this provides a platform for potential new molecularly based therapeutic interventions.