gebhart/patrepeval huggingface dataset:
Electrochemical Properties of Electroactive Monolayers Having $[Os(bpy)_3]^{2+}$ Moieties (2001)

Self-assembled monolayers (SAMs) of the alkylthiols with [Os(bpy)3]2+ moiety at the terminal position were prepared on gold electrode surface. Examination of the cyclic voltammograms for the SAM shows that it does not organize well unlike alkylthiols, which is attributed to the much larger diameter of [Os(bpy)3]2+ moiety compared with the cross-section of alkyl chains and the distance between the adsorption sites. Electromicro-gravimetry study shows that the hydration numbers of the electrolyte were 16 ±2, 11 ±1, 5 ± 1 and 24 ±6 for ClO4−, PF6−, NO3−, and SO42−, respectively. The binary SAMs of alkylthiols with [Os(bpy)3]2+ terminal-group were prepared by co-adsorption of alkylthiols as spacer molecules, which results in better packing in SAM and accordingly the stability was enhanced.
Variations Among Experienced Surgeons in Cancer Control After Open Radical Prostatectomy (2010)

Patient risk of recurrence may differ depending on which of 2 surgeons is seen even if the surgeons have similar experience levels. Surgical randomized trials are imperative to determine and characterize the roots of these variations.
Evidence That a Novel 8-Phenyl-Substituted Xanthine Derivative is a Cardioselective Adenosine Receptor Antagonist In Vivo (1987)

The ability of caffeine, enprofylline (3-propylxanthine), 8-phenyltheophylline, 8-p-sulphophenyl-theophylline, 8-(4'-carboxymethyloxyphenyl)-1,3-dipropylxanthine, and 8-(4'-carboxymethyloxyphenyl)-1,3-dipropylxanthine-2-aminoethyl amide (XAC) to antagonize the effects of an adenosine analogue, N-5'-ethylcarboxamidoadenosine, on heart rate and blood pressure in anesthetized rats was examined. The first five xanthine derivatives were equally active in antagonizing the two responses. By contrast, XAC was approximately 20 times more potent in antagonizing the heart rate response than the blood pressure response. Measurements of the concentration of XAC in plasma and brain indicate that it penetrates the central nervous system poorly. It is concluded that XAC is a cardioselective adenosine antagonist, and since adenosine is supposed to reduce heart rate via an effect on A1-receptors, and the blood pressure via A2-receptors, XAC may be a selective A1-adenosine receptor antagonist in vivo.
Proteomics of protein trafficking by in vivo tissue-specific labeling (2020)

Abstract Secreted interorgan communication factors encode key regulators of homeostasis. However, long-standing questions surround their origins/destinations, mechanisms of interactions, and the number of proteins involved. Progress has been hindered by the lack of methodologies for these factors’ large-scale identification and characterization, as conventional approaches cannot identify low-abundance factors and the origins and destinations of secreted proteins. We established an in vivo platform to investigate secreted protein trafficking between organs proteome-wide, whereby engineered promiscuous biotin ligase BirA*G3 (a relative of TurboID) biotinylates all proteins in a subcellular compartment of one tissue, and biotinylated proteins are affinity-enriched and identified from distal organs using quantitative mass spectrometry. Using this platform, we identified 51 putative muscle-secreted proteins from heads and 269 fat body-secreted proteins from legs/muscles, of which 60-70% have human orthologs. We demonstrate, in particular, that conserved fat body-derived novel interorgan communication factors CG31326, CG2145, and CG4332 promote muscle activity. Our results indicate that the communication network of secreted proteins is vast, and we identified systemic functions for a number of these factors. This approach is widely applicable to studies in interorgan, local and intracellular protein trafficking networks, non-conventional secretion, and to mammalian systems, under healthy or diseased states. One Sentence Summary We developed an in vivo platform to investigate protein trafficking between organs proteome-wide, provide a resource for interorgan communication factors, and determined conserved adipokines that affect muscles.
A new ESD design methodology for high voltage DMOS applications (2010)

A comprehensive methodology for synthesizing robust ESD performance in highly sensitive high voltage NLDMOS functional blocks is introduced. Optimizing high voltage output stage design for robust device- and system-level (IEC 61000-4-2)/HMM is assessed under 1-, 2-, 5-, 10- ,100-ns wide time frames of typical electrostatic discharge (ESD) stress models.
Characterization of a calcified intra-cardiac pseudocyst of the mitral valve by magnetic resonance imaging including T1 and T2 mapping (2014)

This case presents the unusual finding of contrast uptake in an intra-cardiac cystic lesion and points to the potential of T1 and T2 mapping for assisting in the characterization and diagnosis of intra-cardiac masses by CMR.
Predictive Computational Models of Substrate Binding by a Nucleoside Transporter (2009)

Transporters play a vital role in both the resistance mechanisms of existing drugs and effective targeting of their replacements. Melarsoprol and diamidine compounds similar to pentamidine and furamidine are primarily taken up by trypanosomes of the genus Trypanosoma brucei through the P2 aminopurine transporter. In standardized competition experiments with [(3)H]adenosine, P2 transporter inhibition constants (K(i)) have been determined for a diverse dataset of adenosine analogs, diamidines, Food and Drug Administration-approved compounds and analogs thereof, and custom-designed trypanocidal compounds. Computational biology has been employed to investigate compound structure diversity in relation to P2 transporter interaction. These explorations have led to models for inhibition predictions of known and novel compounds to obtain information about the molecular basis for P2 transporter inhibition. A common pharmacophore for P2 transporter inhibition has been identified along with other key structural characteristics. Our model provides insight into P2 transporter interactions with known compounds and contributes to strategies for the design of novel antiparasitic compounds. This approach offers a quantitative and predictive tool for molecular recognition by specific transporters without the need for structural or even primary sequence information of the transport protein.
Novel method of gain clamping in C-band erbium dopedfiber amplifier (2004)

A novel technique of gain clamping in C-band erbium-doped fiber amplifiers (EDFAs) is presented. It uses a single fiber Bragg grating (FBC) on the input side of erbium-doped fiber (EDF) to reflect a portion of backward amplified spontaneous emission (ASE) back into EDFA. A gain clamping is achieved in EDFA with FBC when the input power dynamic range varies from –36.0 dBm to –4.0 dBm. Efficient flat-gain spectrum in C-band EDFAs is achieved by adding a FBG and it is compared with a conventional EDFA without FBG.
In PSC with dominant bile duct stenosis, multi-resistant bacteriobilia is associated with reduced survival (2017)

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease, characterized by sclerosis and destruction of the biliary system. The course of diseases is often complicated by biliary infections.
Eremantholide A, a novel tumor-inhibiting compound from Eremanthus elaeagnus (Compositae) (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEremantholide A, a novel tumor-inhibiting compound from Eremanthus elaeagnus (Compositae)Robert F. Raffauf, Pih-Kuei C. Huang, Philip W. Le Quesne, Steven B. Levery, and Thomas F. BrennanCite this: J. Am. Chem. Soc. 1975, 97, 23, 6884–6886Publication Date (Print):November 1, 1975Publication History Published online1 May 2002Published inissue 1 November 1975https://pubs.acs.org/doi/10.1021/ja00856a059https://doi.org/10.1021/ja00856a059research-articleACS PublicationsRequest reuse permissionsArticle Views183Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Kantenelementbasierte BEM mit DeRham-Kollokation für Elektromagnetismus (2004)

In der vorliegenden Arbeit wurden Randintegralgleichungen für elektromagnetische Probleme betrachtet und in der Sprache der Differentialformen umformuliert. Dabei können die Integralkerne als Doppelformen aufgefasst werden. Kontinuierliche Differentialformen besitzen diskrete Entsprechungen, nämlich diskrete Differentialformen, so dass die entstandene Formulierung eine natürliche Diskretisierung ermöglicht. Eine neue Vorgehensweise mit Hilfe der DeRham-Abbildungen, die hier präsentiert wird, bietet eine Alternative zur bekannten Galerkin-Diskretisierung und verallgemeinert die klassische Punktkollokationsmethode. Die hier beschriebene Randelementmethode wurde zusätzlich in einer Kopplung mit der Finite-Elemente-Methode realisiert. Einige numerische Ergebnisse der Randelementmethode und der kantenelementbasierten BEM-FEM-Kopplung sind in der Arbeit präsentiert.
A Simple Minimum Rate Supporting Scheduler for High Speed Downlink Packet Access (2004)

A simple Minimum Rate Supporting Scheduler (MRSS) is proposed for HSDPA (High Speed Downlink Packet Access). MRSS guides the user selection in order to provide, if any, a prespecified minimum rate for each user. The simulation results show that MRSS successfully supports to keep the minimum rate up to fairly high traffic load, where existing methods fail, with tolerable degradation in throughput.
Particle Swarm Optimization in an adaptive resonance framework (2015)

A Particle Swarm Optimization (PSO) technique, in conjunction with Fuzzy Adaptive Resonance Theory (ART), was implemented to adapt vigilance values to appropriately compensate for a disparity in data sparsity. Gaining the ability to optimize a vigilance threshold over each cluster as it is created is useful because not all conceivable clusters have the same sparsity from the cluster centroid. Instead of selecting a single vigilance threshold, a metric must be selected for the PSO to optimize on. This trades one design decision for another. The performance gain, however, motivates the tradeoff in certain applications.
Supplementary Figure 2 from Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma (2023)

&lt;p&gt;PDF file - 128KB, Transduction efficiencies of infused transgenic cells.&lt;/p&gt;
Potential of sub-microsecond laser pulse shaping for controlling microcavitation in selective retinal therapies (2019)

Pilot results showing the potential of sub-microsecond laser pulse shaping to optimize thermomechanical confinement in laser-tissue interactions involving microcavitation are presented. Model samples based on aqueous suspensions of retinal melanosomes and eumelanin particles were irradiated at 532 nm with nanosecond laser pulses and picosecond laser pulse trains having differing shapes and durations. The cavitation threshold radiant exposure and the bubble lifetime above the threshold were measured using a pump-probe setup and sub-nanosecond time-resolved imaging. Both quantities were found to strongly depend on the pulse format. These results suggest that sub-microsecond laser pulse shaping could be exploited to optimize precision and control in numerous applications of laser-directed microcavitation, including selective retinal laser treatments.
Material properties in Si-Ge/Ge quantum wells for silicon-integrated electro-absorption devices (2008)

The quantum-confined Stark effect demonstrated in Si-Ge/Ge quantum wells promises integration of optics with silicon ICs. Using photocurrent, tunneling resonance and nonparabolicity, we propose more accurate values of key parameters for device design.
Adiabatic J cross-polarization in liquids for signal enhancement in NMR (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdiabatic J cross-polarization in liquids for signal enhancement in NMRG. C. Chingas, A. N. Garroway, W. B. Moniz, and R. D. BertrandCite this: J. Am. Chem. Soc. 1980, 102, 8, 2526–2528Publication Date (Print):April 1, 1980Publication History Published online1 May 2002Published inissue 1 April 1980https://pubs.acs.org/doi/10.1021/ja00528a002https://doi.org/10.1021/ja00528a002research-articleACS PublicationsRequest reuse permissionsArticle Views277Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A framework for classification and segmentation of massive audio data streams (2007)

In recent years, the proliferation of VOIP data has created a number of applications in which it is desirable to perform quick online classification and recognition of massive voice streams. Typically such applications are encountered in real time intelligence and surveillance. In many cases, the data streams can be in compressed format, and the rate of data processing can often run at the rate of Gigabits per second. All known techniques for speaker voice analysis require the use of an offline training phase in which the system is trained with known segments of speech. The state-of-the-art method for text-independent speaker recognition is known as Gaussian Mixture Modeling (GMM), and it requires an iterative Expectation Maximization Procedure for training, which cannot be implemented in real time. In this paper, we discuss the details of such an online voice recognition system. For this purpose, we use our micro-clustering algorithms to design concise signatures of the target speakers. One of the surprising and insightful observations from our experiences with such a system is that while it was originally designed only for efficiency, we later discovered that it was also more accurate than the widely used Gaussian Mixture Model (GMM). This was because of the conciseness of the micro-cluster model, which made it less prone to over training. This is evidence of the fact that it is often possible to get the best of both worlds and do better than complex models both from an efficiency and accuracy perspective.
Post-Thaw Function and Caspase Activity of Cryopreserved Hepatocyte Aggregates (2004)

Long-term preservation of hepatocytes is essential to a wide variety of applications, including drug metabolism studies, cell transplantation, and extra-corporeal liver support. Our previous studies have shown that the pre-culture of hepatocytes prior to cryopreservation can enhance post-thaw viability. The aim of this study was to characterize the post-thaw function of the hepatocytes for longer periods of time and to quantify the role of post-thaw apoptosis in the results observed. To that end, hepatocytes were frozen, thawed, and cultured in a hollow-fiber bioreactor. Albumin secretion and oxygen consumption were measured over a period of up to 9 days. The postthaw albumin secretion for cells pre-cultured for 24 h prior to cryopreservation was greater than that measured in cells that were not pre-cultured prior to cryopreservation. Annexin V-FITC/Propidium iodine staining and caspase- 3 activity measurements indicated that apoptosis was higher in frozen and thawed cells that had not been pre-cultured compared to cells cultured to form aggregates. These results suggest that differences in post-thaw function for cells, with or without pre-culture, may involve differences in the propensity of post-thaw apoptosis.
Design of efficient simple coma architectures (2000)

Distributed shared-memory machines that are designed as Simple Cache-Only Memory Architecture (S-COMA) allow automatic replication and migration of data in the main memory like traditional COMA organizations. S-COMA performs in software many of the tasks that the latter did in hardware. Even then the cost-effectiveness of the S-COMA proposal is hindered by some performance bottlenecks and hardware overheads. Those issues are addressed in this work. Since the allocation unit of data in S-COMA is a page, there is a possibility of memory fragmentation. This can lead to poor utilization of memory, and frequent page faults. To solve the memory fragmentation problem, this work proposes an extension to S-COMA called Multiplexed Simple Coma (MS-COMA). The idea is to allow multiple virtual pages to map into the same physical page at the same time, therefore compressing the page working set of the application. MS-COMA requires very little support over S-COMA and reduces its execution time by about 40%. We find that MS-COMA can be implemented with off-the-shelf processors. S-COMA has a second drawback which has been addressed in this work. To enforce coherence efficiently in hardware, S-COMA requires a global address space; SRAM tables for physical-to-global and global-to-physical address translations are to be provided. However for large systems with few gigabytes of memory per node, these tables will be few megabytes of SRAM. The additional cost of S-COMA implementation comes primarily from these translation tables and the two bits of states per line of memory required to maintain coherence, as has been observed in the implementation of the WildFire prototype from Sun Microsystems. In this work, we propose a novel technique of combining the two translation tables. Further benefit could be obtained by caching the resulting data structure. The reduction in cost is significant and is attained with negligible impact on performance. Overall, we believe this work has improved the cost-effectiveness of the S-COMA architecture. Our address translation hardware is then used to improve on existing approaches for managing pages between S-COMA and CC-NUMA modes in hybrid systems.
Ultrasonography: turning the corner (2022)

Ultrasonography (renamed from the Journal of Korean Society of Ultrasound in Medicine in January 2014), the official English-language journal of the Korean Society of Ultrasound in Medicine (KSUM), is an international peer-reviewed academic journal dedicated to practice, research, technology, and education dealing with medical ultrasound, Aims and Scope:Ultrasonography (renamed from the Journal of Korean Society of Ultrasound in Medicine in January 2014), the official English-language journal of the Korean Society of Ultrasound in Medicine (KSUM), is an international peer-reviewed academic journal dedicated to practice, research, technology, and education dealing with medical ultrasound.It is published four times per year: January 1, April 1, July 1, and October 1. Original articles, topical reviews, pictorial essays, and notable case reports are published in Ultrasonography covering state-of-the-art content. Ultrasonography also serves as a medium for cooperation among physicians and specialists from around the world who are focusing on various ultrasound technology and disease problems.
Assessing the future of diffuse optical imaging technologies for breast cancer management (2008)

Diffuse optical imaging (DOI) is a noninvasive optical technique that employs near-infrared (NIR) light to quantitatively characterize the optical properties of thick tissues. Although NIR methods were first applied to breast transillumination (also called diaphanography) nearly 80 years ago, quantitative DOI methods employing time- or frequency-domain photon migration technologies have only recently been used for breast imaging (i.e., since the mid-1990s). In this review, the state of the art in DOI for breast cancer is outlined and a multi-institutional Network for Translational Research in Optical Imaging (NTROI) is described, which has been formed by the National Cancer Institute to advance diffuse optical spectroscopy and imaging (DOSI) for the purpose of improving breast cancer detection and clinical management. DOSI employs broadband technology both in near-infrared spectral and temporal signal domains in order to separate absorption from scattering and quantify uptake of multiple molecular probes based on absorption or fluorescence contrast. Additional dimensionality in the data is provided by integrating and co-registering the functional information of DOSI with x-ray mammography and magnetic resonance imaging (MRI), which provide structural information or vascular flow information, respectively. Factors affecting DOSI performance, such as intrinsic and extrinsic contrast mechanisms, quantitation of biochemical components, image formation/visualization, and multimodality co-registration are under investigation in the ongoing research NTROI sites. One of the goals is to develop standardized DOSI platforms that can be used as stand-alone devices or in conjunction with MRI, mammography, or ultrasound. This broad-based, multidisciplinary effort is expected to provide new insight regarding the origins of breast disease and practical approaches for addressing several key challenges in breast cancer, including: Detecting disease in mammographically dense tissue, distinguishing between malignant and benign lesions, and understanding the impact of neoadjuvant chemotherapies.
Supplemental Figure 2 from miR-196b Is Epigenetically Silenced during the Premalignant Stage of Lung Carcinogenesis (2023)

&lt;p&gt;Analysis of miR-196b and miR-34c-5p hypermethylation in NSCLC.&lt;/p&gt;
Unified steady-state model and DC analysis of half-bridge DC-DC converters with current doubler rectifier (2004)

Half-bridge DC-DC converter with a current doubler rectifier is suited for low-voltage high-current on-board DC-DC converters. In this paper, a unified steady-state model for both asymmetric and symmetric half-bridge DC-DC converter is derived, and the converter DC solution is obtained. Based on the steady-state solution, several issues, such as inductor current sharing and transformer DC bias of magnetizing current, are addressed. In addition, a series of design rules resulting from mathematical analysis are discussed. The analysis is verified by simulation and experimental results.