gebhart/patrepeval huggingface dataset:
Dual Specificity of the Pyrimidine Analogue, 4-Methylpyridin-2-one, in DNA Replication (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDual Specificity of the Pyrimidine Analogue, 4-Methylpyridin-2-one, in DNA ReplicationIchiro Hirao, Takashi Ohtsuki, Tsuneo Mitsui, and Shigeyuki YokoyamaView Author Information Yokoyama CytoLogic Project, ERATO, JST c/o RIKEN, Hirosawa, Wako-shi, Saitama 351-0198, Japan Genomic Sciences Center, RIKEN Hirosawa, Wako-shi, Saitama 351-0198, Japan Department of Biophysics and Biochemistry Graduate School of Science, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan Cite this: J. Am. Chem. Soc. 2000, 122, 25, 6118–6119Publication Date (Web):June 9, 2000Publication History Received13 September 1999Published online9 June 2000Published inissue 1 June 2000https://pubs.acs.org/doi/10.1021/ja993291ohttps://doi.org/10.1021/ja993291orapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views362Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Chemical specificity,Genetics,Monomers,Selectivity Get e-Alerts
Untersuchung von intrinsisch unstrukturierten Proteinen mithilfe des Austausches mit hyperpolarisiertem Wasser (2016)

Abstract Hyperpolarisiertes Wasser kann NMR‐Signale schnell austauschender Protonen des intrinsisch unstrukturierten Proteins Osteopontin (OPN), welches eine Rolle bei Metastasenbildung spielt, bei annähernd physiologischem pH‐Wert und Temperatur verstärken. Der Transfer der Magnetisierung des hyperpolarisierten Wassers beschränkt sich auf lösungsmittelexponierte Aminosäuren und verstärkt deshalb nur selektiv bestimmte Signale in ( 1 H, 15 N‐)Korrelationsspektren. Die Bindung des Polysaccharids Heparin induziert die Entfaltung vorgeformter Strukturelemente von OPN.
Metastatic Adenocarcinoma of the Prostate: Presentation as a Pleural-Based Mass (1993)

We have presented an unusual case of metastatic prostate carcinoma simulating a primary bone tumor. Although previous reports have described periosteal and "pseudosarcomatous" prostate metastases, no report makes reference to rib involvement. Furthermore, the large soft tissue component is highly unusual. This case illustrates that although such lesions are rare, in the older patient, metastases should be included along with primary tumors in the differential diagnosis of a spiculated bone lesion with prominent soft tissue involvement.
Distance associativity for high-performance energy-efficient non-uniform cache architectures (2004)

Wire delays continue to grow as the dominant component of latency for large caches. A recent work proposed adaptive, non-uniform cache architecture (NUCA) to manage large, on-chip caches. By exploiting the variation in access time across widely-spaced subarrays, NUCA allows fast access to close subarrays while retaining slow access to far subarrays. While the idea of NUCA is attractive, NUCA does not employ design choices commonly used in large caches, such as sequential tag-data access for low power. Moreover, NUCA couples data placement with tag placement that is possible in a non-uniform access cache. Consequently, NUCA can place only a few blocks within a given cache set in the fastest subarrays, and must employ a high-bandwidth switched network to swap blocks within the cache for high performance. In this paper, we propose the non-uniform access with replacement and placement using distance associativity cache or NuRAPID, which leverages sequential tag-data access to decouple data placement from tag placement. Distance associativity, the placement of data at a certain distance (and latency), is separated from set associativity, the placement of tags within a set. This decoupling enables NuRAPID to place flexibly the vast majority of frequently-accessed data in the fastest subarrays, with fewer swaps than NUCA. Distance associativity fundamentally changes the trade-offs made by NUCA's best-performing design, resulting in higher performance and substantially lower cache energy. A one-ported, non-banked NuRAPID cache improves performance by 3% on average and up to 15% compared to a multi-banked NUCA with an infinite-bandwidth switched network, while reducing L2 cache energy by 77%.
Early colonizingEsche richia colielicits remodeling of rat colonic epithelium shifting toward a new homeostatic state (2014)

We investigated the effects of early colonizing bacteria on the colonic epithelium. We isolated dominant bacteria, Escherichia coli, Enterococcus faecalis, Lactobacillus intestinalis, Clostridium innocuum and a novel Fusobacterium spp., from the intestinal contents of conventional suckling rats and transferred them in different combinations into germfree (GF) adult rats. Animals were investigated after various times up to 21 days. Proliferative cell markers (Ki67, proliferating cell nuclear antigen, phospho-histone H3, cyclin A) were higher in rats monocolonized with E. coli than in GF at all time points, but not in rats monocolonized with E. faecalis. The mucin content of goblet cells declined shortly after E. coli administration whereas the mucus layer doubled in thickness. Fluorescence in situ hybridization analyses revealed that E. coli resides in this mucus layer. The epithelial mucin content progressively returned to baseline, following an increase in KLF4 and in the cell cycle arrest-related proteins p21(CIP1) and p27(KIP1). Markers of colonic differentiated cells involved in electrolyte (carbonic anhydrase II and slc26A3) and water (aquaglyceroporin3 (aqp3)) transport, and secretory responses to carbachol were modulated after E. coli inoculation suggesting that ion transport dynamics were also affected. The colonic responses to simplified microbiotas differed substantially according to whether or not E. coli was combined with the other four bacteria. Thus, proliferation markers increased substantially when E. coli was in the mix, but very much less when it was absent. This work demonstrates that a pioneer strain of E. coli elicits sequential epithelial remodeling affecting the structure, mucus layer and ionic movements and suggests this can result in a microbiota-compliant state.
Soliton transmission in cascaded distributed erbium-doped fiber amplifiers (1993)

Soliton is considered to be the carrier for high bit–rate and long distance fiber communication system. Because of fiber loss, soliton is amplified periodically to maintain its power. Recently, lumped erbium-doped fiber amplifier (LEDFA) is successfully demonstrated to amplify the soliton. 1 However, soliton experiences large power perturbation with LEDFA and it is stable only when the soliton period is much larger than the pump period. 2 Thus the soliton pulsewidth can not be too short for long distance transmission. To reduce power perturbation, distributed erbium-doped fiber amplifier (DEDFA) is suggested. 3 We numerically study soliton propagating in the cascaded DEDFAs of different doping densities. The results show that, for the soliton period less than the pump period, the soliton pulseshape can maintain well with the cascaded DEDFAs of proper doping density, but optical bandpass filter between DEDFAs is required to reduce neighboring interaction and maintain soliton separation. For example, with lpsec/km/nm dispersion, 30km pump period and 650GHz bandwidth filter, the pulseshape and separation of a 5psec soliton pair (9.9km soliton period) with 10 pulsewidth separation can maintain well over 10Mm. In this case, the maximum power variation is 3.2%; while, with LEDFA, it is 84%. Furthermore, the required pump power is greatly reduced to compare with the Raman amplifiers.
Ursodeoxycholyl Lysophosphatidylethanolamide modifies aberrant lipid profiles in NAFLD (2015)

UDCA-LPE modulates defective fatty acid metabolism during experimental NAFLD thereby restoring altered lipid profiles in addition to its pronounced anti-inflammatory effects. Thus, UDCA-LPE may be a promising drug candidate for the management of NAFLD.
Fourier Transform Optical Beamformer Employing Spatial Light Modulator (2007)

Optically controlled beam forming techniques are effective for phased-array antenna control. We have developed the Fourier transform optical beamformer (FT-OBF). The antenna radiation pattern inputted into an amplitude spatial light modulator (A-SLM) is optically Fourier transformed to a specific phase-front light beam equivalent to an antenna excitation in the FT-OBF. Optical signal processing, used the Fourier transform optics, is effective to large-scale, two-dimensional, and high-speed signal processing. To implement a flexible and finer antenna beam pattern control, we use an A-SLM as input image formation of the FT optics. And, to realize a small-size FT-OBF, we use symmetric triplet lenses with convex, concave and convex lens. The total optical system becomes below 1/5 length compared with the length using single lens. Finally, we evaluated the developed FT-OBF with the generated amplitude and phase distributions, which excitation signal of an array antenna. We measured an antenna radiation beam pattern, beam steering and beam width control, in the C-band. Measurement results agreed with theoretical calculated results. These results show the feasibility of the spatial light modulator based FT-OBF.
Repeatability of radiomics and machine learning for DWI: Short‐term repeatability study of 112 patients with prostate cancer (2019)

Surface-to-volume ratio and corner detectors for prostate DWI led to good classification of unseen data and performed similarly in Scan1 and Scan2 in contrast to multiple conventional radiomic features.
Sensitivity Enhancement for Quantitative Electrochemical Determination of a Trace Amount of Accelerator in Copper Plating Solutions (2011)

An accelerator is an indispensable organic additive for the bottom-up filling of copper electroplating in nano- or micro-scale features. However, its effective concentration is too low to be easily determined and controlled. Herein, a new electrochemical analysis method based on self-assembly monolayers of thiol molecules on a gold electrode was developed to accurately determine a trace amount of accelerator. The accelerator employed in copper plating solutions is bis-(3-sulfopropyl) disulfide (SPS), which is the most common accelerator for the filling of vias and trenches of interconnects. The SPS concentration in copper plating solutions ranged from 0.3 to 9.0 ppm. Following selective chemisorption of SPS onto the gold electrode, the SPS-modified gold electrode was transferred into a specific electrolyte composed of CuSO4, H2SO4, polyethylene glycol and chloride ions to run cyclic voltammetry (CV) for copper deposition and stripping. A specific peak current of copper reduction formed in the CV, and its peak area depended on the SPS concentration in the copper plating solution. A good linear calibration line was obtained by using this electrochemical analysis method, which can determine a trace amount of SPS in a concentration range of 0.3–1.0 ppm, which is a significant challenge for traditional instruments.
Designing for improved social responsibility, user participation and content in on-line communities (2002)

Web sites face difficult challenges in supporting successful communities. In this paper we discuss 2 operating web sites, identically designed but with different and distinct audiences. These sites collect user data from site activity and feed it back to the user community in novel ways. The sites are highly active and growing, and have fostered socially conscious, easily navigable and comprehensible on-line communities with little cost and maintenance. The practice of user data collection and re-purposing we describe works particularly well in highly contextual or information /resource-driven communities. These sites also integrate custom content authoring tools and track their use. The authoring tools were designed to quickly grow a specialized "knowledge base" of content created by users and published to a larger audience. A status system encourages the participation of users to contribute to this knowledge base, while increasing social awareness and responsibility in areas of high user interaction. All user activity, communications, and feedback are tracked. Then data is compiled and re-incorporated into scalable solutions for better navigability, content filtering, and presentation of contents to a larger audience. This practice creates a uniquely high quality of interaction within web communities
Release of inorganic trace elements from high-temperature gasification of coal (2011)

The development of cleaner, more efficient techniques in next-generation coal power plants is becoming increasingly important, especially regarding to the discussion of the influence of CO2 emissions on global warming. A promising coal utilisation proess is the integrated gasification combined cycle process. The direct use of the raw gas requires gas clean-up to prevent downstream parts of the gasifier from several problems. An increased efficiency and a decreased amount of harmful species can be achieved through hot fuel gas cleaning. This clean-up technique requires a comprehensive knowledge of the release characteristics of inorganic coal constituents. The aim of this thesis was to provide enhanced knowledge of the effect of key process parameters and of the chemical constitution of coal on the release of Na, K, S, and Cl species from high-temperature coal gasification. The experimental setup consisted of atmospheric flow tube furnaces and a pressurised furnace. In-situ analysis of the product gas was carried out using molecular beam mass spectrometry. A broad spectrum of different coals with assumed qualitative and quantitative differences in the release characteristics was investigated. Additionally, experiments with model substances were performed. The results of the experimental investigation were compared with thermodynamic calculations. Finally, recommendations, for the operation of a high-temperature gasifier are formulated.
Dissecting the genetic and metabolic mechanisms of adaptation to the knockout of a major metabolic enzyme inEscherichia coli (2017)

Unraveling the mechanisms of microbial adaptive evolution following genetic or environmental challenges is of fundamental interest in biological science and engineering. When the challenge is the loss of a metabolic enzyme, adaptive responses can also shed significant insight into metabolic robustness, regulation, and areas of kinetic limitation. In this study, whole-genome sequencing and high-resolution <sup>13</sup>C-metabolic flux analysis were performed on 10 adaptively evolved <i>pgi</i> knockouts of <i>Escherichia coli</i><i>Pgi</i> catalyzes the first reaction in glycolysis, and its loss results in major physiological and carbon catabolism pathway changes, including an 80% reduction in growth rate. Following adaptive laboratory evolution (ALE), the knockouts increase their growth rate by up to 3.6-fold. Through combined genomic-fluxomic analysis, we characterized the mutations and resulting metabolic fluxes that enabled this fitness recovery. Large increases in pyridine cofactor transhydrogenase flux, correcting imbalanced production of NADPH and NADH, were enabled by direct mutations to the transhydrogenase genes <i>sthA</i> and <i>pntAB</i> The phosphotransferase system component <i>crr</i> was also found to be frequently mutated, which corresponded to elevated flux from pyruvate to phosphoenolpyruvate. The overall energy metabolism was found to be strikingly robust, and what have been previously described as latently activated Entner-Doudoroff and glyoxylate shunt pathways are shown here to represent no real increases in absolute flux relative to the wild type. These results indicate that the dominant mechanism of adaptation was to relieve the rate-limiting steps in cofactor metabolism and substrate uptake and to modulate global transcriptional regulation from stress response to catabolism.
Anionic hetero(3,3)rearrangements. N,O-diacylhydroxylamines to succinic acid derivatives. (1994)

N, O-Diacylhydroxylamines rearrange under basic conditions to afford 2, 3-disubstituted succinic acid derivatives. The rearrangement can be rationalized in terms of [3, 3]sigmatropic shifts of ester-amide dienolated N, O-diacylhydroxylamines.
ChemInform Abstract: Palladium‐Catalyzed Reactions for Fine Chemical Synthesis. Part 2. First Palladium‐Catalyzed Aminations of Aryl Chlorides. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Phase 2 study of BACOPP (bleomycin, adriamycin, cyclophosphamide, vincristine, procarbazine, and prednisone) in older patients with Hodgkin lymphoma: a report from the German Hodgkin Study Group (GHSG) (2010)

For older patients with early unfavorable or advanced stage Hodgkin lymphoma (HL) the prognosis is much worse than for younger HL patients. We thus developed a new regimen, BACOPP (bleomycin, adriamycin, cyclophosphamide, vincristine, procarbazine, and prednisone), to improve both tolerability and efficacy of treatment for older HL patients. Between 2004 and 2005, 65 patients with early unfavorable or advanced stage HL aged between 60 and 75 years were enrolled in this phase 2 trial. Treatment consisted of 6 to 8 cycles of BACOPP. Residual tumor masses were irradiated. Primary endpoints were feasibility as determined by adherence to protocol and overall response rate. Secondary endpoints included toxicity, freedom from treatment failure, and progression free and overall survival. For the final analysis 60 patients (92%) were eligible; 75% of treatment courses were administered according to protocol. World Health Organization grade 3/4 toxicities occurred in 52 patients. Fifty-one patients (85%) achieved complete remission, 2 (3%) partial remission, and 4 (7%) developed progressive disease. With a median observation time of 33 months, 18 patients died (30%), including 7 treatment-associated deaths. Three patients died before response assessment. Thus, the BACOPP regimen is active in older HL patients but is compromised by a high rate of toxic deaths. This trial was registered at www.clinicaltrials.gov as #NCT00284271.
A novel teleoperated long-reach manipulator testbed and its remote capabilities via the Internet (2002)

During the 1995 DOE Robotics Forum at Albuquerque, New Mexico, Georgia Tech's Intelligent Machine Dynamics Laboratory demonstrated remote display capabilities of its telemanipulated long-reach manipulator testbed through the Internet. This paper describes the testbed and addresses the methods, limitations, and capabilities of remote operations.
Active Fourier Transform Hyperspectral Imaging Using a High-Speed Camera (2021)

We present initial results from a prototype hyperspectral imaging and ranging system. The system utilizes a high-speed imaging detector, enabling source modulation without stabilization.
On the widths of dislocation images in X-ray topography under low-absorption conditions (1975)

Detailed measurements have been made of dislocation image widths in X-ray topographs taken under conditions of low absorption (product of linear absorption coefficient and crystal thickness, μt = 0.15) with a silicon specimen and Mo Kα radiation. These have been compared with two theoretical models, the `diffracting-zone' model involving computation of misorientation gradient contours, and the direct-image `mosaic' model using calculations of effective misorientation contours. Neither model completely explains the image widths. The diffracting-zone model, though theoretically more attractive, gives a very poor correlation, probably because of (a) severe photographic limitations and (b) the uncertainty in the reconstruction of the intermediary image in translation topographs. For a given reflection the direct-image mosaic model gives a reasonably good prediction of image widths measured at half peak height. However, the widths in different reflections are not self-consistent; in particular, images in lower-order reflections are significantly wider than those predicted by the model. This implies that contributions from interbranch scattering (giving an intermediary image component) are more important in lower-order reflections, and that such contributions are proportional to the widths obtained from misorientation (rather than misorientation gradient) contours.
Measurable Residual Disease by Next-Generation Flow Cytometry in Multiple Myeloma (2019)

The IMWG flow MRD-negative response criterion is highly applicable and sensitive to evaluate treatment efficacy in MM.
Review Article Development of NGR peptide-based agents for tumor imaging (2011)

Molecular imaging allows direct visualization of targets and characterization of cellular pathways, as long as a high signal/background ratio can be achieved, which requires a sufficient amount of probes to accumulate in the imaging region. The Asn-Gly-Arg (NGR) tripeptide selected by phage display can specifically target tumor vasculature. Recognizing the aminopeptidase N (APN or CD13) receptor on the membrane of tumor cells, the peptide can be fur- ther internalized into cytoplasma by the endosomal pathway. Hence NGR can serve as an ideal candidate for tumor imaging, once it is conjugated with fluorescent or radiolabeled imaging probes. Herein, we highlight some recent developments of NGR peptide based imaging of tumors. Although still in the preliminary stage, some NGR probes have shown potential as promising agents in future clinical applications.
Magnetotransport study of valley-polarized electrons in synthetic diamond (2016)

We demonstrate that the highly stable valley-polarized electron states in ultrapure single-crystalline diamond allow for investigation of charge transport, magnetoresistivity, and determination of the dominant scattering mechanism. The Hall effect gives rise to nonisotropic contributions in the mobility tensor that were measured at a temperature of 70 K in a time-of-flight setup with an added magnetic field. The observations of the magnetotransport of valley-polarized electrons in diamond are compared with both Monte Carlo simulations and an analytical model based on the Boltzmann transport equation. We establish that acoustic phonon scattering is the dominant electron scattering mechanism at 70 K for each of the valley polarizations in the investigated samples.
Phase I clinical trial of adoptive cellular immunotherapy with APN401 in patients with solid tumors (2015)

Meeting abstracts Casitas-B-lineage lymphoma protein-b (Cbl-b), an E3 ubiquitin ligase, has been identified as a key intracellular checkpoint limiting lymphocyte activation. Inhibiting Cbl-b has been shown to enhance T cell and natural killer cell mediated antitumor activity in mouse tumor models.