gebhart/patrepeval huggingface dataset:
Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1 (2013)

Extracellular vesicles have emerged as important mediators of intercellular communication in cancer, including by conveying tumor-promoting microRNAs between cells, but their regulation is poorly understood. In this study, we report the findings of a comparative microRNA profiling and functional analysis in human glioblastoma that identifies miR-1 as an orchestrator of extracellular vesicle function and glioblastoma growth and invasion. Ectopic expression of miR-1 in glioblastoma cells blocked in vivo growth, neovascularization, and invasiveness. These effects were associated with a role for miR-1 in intercellular communication in the microenvironment mediated by extracellular vesicles released by cancer stem-like glioblastoma cells. An extracellular vesicle-dependent phenotype defined by glioblastoma invasion, neurosphere growth, and endothelial tube formation was mitigated by loading miR-1 into glioblastoma-derived extracellular vesicles. Protein cargo in extracellular vesicles was characterized to learn how miR-1 directed extracellular vesicle function. The mRNA encoding Annexin A2 (ANXA2), one of the most abundant proteins in glioblastoma-derived extracellular vesicles, was found to be a direct target of miR-1 control. In addition, extracellular vesicle-derived miR-1 along with other ANXA2 extracellular vesicle networking partners targeted multiple pro-oncogenic signals in cells within the glioblastoma microenvironment. Together, our results showed how extracellular vesicle signaling promotes the malignant character of glioblastoma and how ectopic expression of miR-1 can mitigate this character, with possible implications for how to develop a unique miRNA-based therapy for glioblastoma management.
Flexo-Ionic Effect of Ionic Liquid Crystal Elastomers (2021)

The first study of the flexo-ionic effect, i.e., mechanical deformation-induced electric signal, of the recently discovered ionic liquid crystal elastomers (iLCEs) is reported. The measured flexo-ionic coefficients were found to strongly depend on the director alignment of the iLCE films and can be over 200 µC/m. This value is orders of magnitude higher than the flexo-electric coefficient found in insulating liquid crystals and is comparable to the well-developed ionic polymers (iEAPs). The shortest response times, i.e., the largest bandwidth of the flexo-ionic responses, is achieved in planar alignment, when the director is uniformly parallel to the substrates. These results render high potential for iLCE-based devices for applications in sensors and wearable micropower generators.
Travelling wave microstrip dipole antennas (1995)

While it is a common antenna, the unloaded conducting microstrip dipole suffers from a very limited bandwidth, because it is a resonant structure supporting a standing wave of current. The authors present the characteristics of a microstrip dipole modified to behave like a travelling wave structure.
Wavelet analysis of tree developments (2002)

In this report we apply the wavelet transformation method to tree patterns in solid insulating materials. The transformation is carried out in two dimensional space. Thus, we use an extended two dimensional wavelet transformation for the analysis of tree patterns.
SOLID PHASE MICROBIAL FERMENTATION OF ANABOLIC STEROID, DIHYDROTESTOSTERONE WITH ASCOMYCETE FUNGUS FUSARIUM OXYSPORUM (2015)

Objective: Microbial catalysis is used in the commercial production of many bioactive steroids. Solid phase microbial fermentation of anabolic steroid, dihydrotestosterone (DHT, 1 ), was carried out with ascomycete fungal strain Fusarium oxysporum (NRRL-1392). Methods: Sabouraud-4% glucose-agar was used to cultivate the fungal cultures as solid phase medium. Substrate 1 was incubated with Fusarium oxysporum (NRRL-1392) for 8 days. Microbial transformed metabolites were purified by using column chromatographic technique. Results: Ascomycete fungal strain Fusarium oxysporum (NRRL-1392), transformed dihydrotestosterone ( 1 ) to four oxidative metabolites 2-5  using solid phase microbial transformation metod. During biotransformation process the hydroxy group was incorporated in inactivated methine carbon atoms at C-7 and C-11 positions. Their structures were elucidated by means of a homo and heteronuclear 2D NMR and by HREI-MS techniques as 17b-hydroxyandrosta-1, 4-dien-3-one 2 , androsta-1, 4-diene-3, 17-dione 3 , 7a, 17b-dihydroxyandrosta-1, 4-dien-3-one ( 4 ), and 11a-hydroxyandrosta-1, 4-diene-3, 17-dione 5 . The relative stereochemistry of newly incorporated hydroxy groups were deduced by 2D NOESY experiment. Conclusion: In conclusion, microbial biocatalysis is an attractive alternative tool for the preparation of new bioactive steroids, which might be difficult to prepare by conventional chemical routes. Furthermore, microbial-catalyzed biotransformations can produce commercially valuable steroidal pharmaceuticals for the pharmaceutical industry.
Foreword (2012)

The 2012 Conference on Intelligent Data Understanding is applications-oriented, with a focus on Earth Sciences, Space Sciences, and Aerospace and Engineering Systems Applications. This year the conference focuses on the theme of developing and understanding approaches that integrate physical models and data. Novel developments in computer science, statistics, and the application domains can help discover new relationships in massive, highly complex data sets.
Pultruded CFRP rods for ground anchor application (1998)

Carbon fiber reinforced plastic (CFRP) rods with spiral surface indentations have been developed as tension elements in prestressed concrete and as anchor tendons in place of conventional prestressing steels. The indented type CFRP rods have sufficient bonding strength to concrete without sacrificing the high tensile strength. As a low cost manufacturing process of the advanced composite, the pultrusion processing method was applied to make CFRP rods continuously. New ground anchors using the pultruded CFRP rods were installed for slope stabilization at Fukuchiyama, Kyoto in March this year.
Bioresorbable, Miniaturized Porous Silicon Needles on a Flexible Water-Soluble Backing for Unobtrusive, Sustained Delivery of Chemotherapy (2020)

Conventional melanoma therapies suffer from the toxicity and side effects of repeated treatments due to the aggressive and recurrent nature of melanoma cells. Less-invasive topical chemotherapies by utilizing polymeric microneedles have emerged as an alternative, but the sustained, long-lasting release of drug cargos remains challenging. In addition, the size of the microneedles is relatively bulky for the small, curvilinear, and exceptionally sensitive cornea for the treatment of ocular melanoma. Here, we report a design of bioresorbable, miniaturized porous-silicon (p-Si) needles with covalently linked drug cargos at doses comparable to those of conventional polymeric microneedles. The p-Si needles are built on a water-soluble film as a temporary flexible holder that can be intimately interfaced with the irregular surface of living tissues, followed by complete dissolution with saline solution within 1 min. Consequently, the p-Si needles remain embedded inside tissues and then undergo gradual degradation, allowing for sustained release of the drug cargos. Its utility in unobtrusive topical delivery of chemotherapy with minimal side effects is demonstrated in a murine melanoma model.
Fluorocarbon and hydrocarbon end groups: effects on mesomorphism and physical properties of smectic liquid crystals (2011)

In this article we examine the effects of cyclohexane and perfluorocyclohexane being used as bulky end groups on the mesomorphism of classical smectic liquid crystal mesogens. The mesogen that is used in this work is typical of the MHPOBC family of materials. The mesophase behaviour is investigated and miscibility studies are carried out. Electro-optical evaluation of the materials is investigated to show the effect of the terminal group on physical properties such as spontaneous polarisation and tilt angle.
Cytotoxic T lymphocyte responses against melanocytes and melanoma (2011)

Our data suggest that CTLs respond to melanoma and melanocytes equally in vitro and directly ex vivo.
Reduction in Power Consumption for Full-Color Active Matrix Organic Light-Emitting Devices (2006)

The active matrix organic light-emitting diode (AMOLED) is expected to serve as next generation flat panels display with the outstanding features of wide viewing angle, vivid images, and quick response. For practical use of full-color AMOLEDs in mobile devices, it is essential to reduce the power consumption, which is generally higher than that of liquid crystal displays (LCDs). For this aim, a red, green, blue, and white (RGBW) pixel format combined with an RGB color filter array (RGBW format) with a common white emission layer (EML) has been developed. We find that the RGBW format can successfully reduce the power consumption of a full-color AMOLED by nearly half that of a conventionally filtered RGB pixel format. This improved power consumption is almost equal to the power consumption of a same-sized LCD. The RGBW format is a promising technique for the further reduction of the power consumption of a full-color AMOLED.
ChemInform Abstract: Heteroaromatic Taxol Analogues: The Chemistry and Biological Activities of 3′‐Furyl and 3′‐Pyridyl Substituted Taxanes. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Modification of Oligomeric Cyanate Ester Polymer Properties with Multi‐Walled Carbon Nanotube‐Containing Particles (2009)

Abstract The properties of an oligomeric cyanate ester polymer were modified by the addition of 0.01–3 wt.‐% multi‐walled carbon nanotube (MWNT) containing particles. The dynamic mechanical behavior and thermal properties of the cyanate ester/MWNT nanocomposites were evaluated. The storage modulus, G ′, of the nanocomposite with 1 wt.‐% MWNT particles was nearly 60 and 600% higher than the neat polymer at 100 and 200 °C, respectively. The glass transition temperature of the nanocomposite was also raised by 30 °C and its thermal stability in air and nitrogen was increased by 58 and 25 °C, respectively. The property improvements are attributed to reinforcement of the cyanate ester as a result of good nanotube dispersion and effective polymer‐MWNT interaction. magnified image
Modeling Chemoepitaxy of Block Copolymer Thin Films using Self-Consistent Field Theory (2013)

Directed self-assembly (DSA) of block copolymers (BCPs) is a promising technology for advanced patterning at future technology nodes. We use Self-Consistent Field Theory (SCFT) to model directed self-assembly (DSA) of PS-PMMA block copolymers on chemically patterned surfaces (chemoepitaxy). We consider the scenario in which the surface is covered by a neutral brush, in which PS-preferential guiding lines are written. The lines have width W and the period of the line pattern is denoted as P. After the DSA process, one expects to see a lamellar pattern with period (P/n), where n is the line multiplication factor. Using SCFT, we investigate the stability of the templated lamellar pattern as a function of (P/L0) and (W/L0), where L0 is the bulk lamellar period. We find that the pattern is most stable if the guiding stripe pattern has a width which is slightly larger than the equilibrium lamellar half-period, and roughly corresponds to (W/L0) = 0.5-0.6, in agreement with earlier studies. The stability of the pattern also depends on the multiplication factor, n; as n is increased, the free energy differences between various morphologies diminish, making the formation of defects more likely. This has significant impact on the practicality of chemoepitaxy for sub-30 nm line and space applications.
Unusual properties of a bent-core liquid-crystalline fluid (2008)

In our investigations of a family of achiral bent-core bis-(phenyl)oxadiazole derivatives, we observed some unusual properties of the nematic phase. These include evidence of segregation into domains of opposite handedness and the formation of clusters, nematic phase biaxiality, and a strongly kinetically governed phase behaviour, which leads to the display of unique filament structures at the onset of new order. We suggest that the combination of a deviant calamitic molecular shape with a considerable transverse dipole leads to an unusual strength and combination of molecular interactions, and as a consequence these nematic materials need to be considered as fluctuating and dynamically changing, multi-hierarchical fluids.
Video-Quality Estimation Based on Reduced-Reference Model Employing Activity-Difference (2009)

This paper presents a Reduced-reference based video-quality estimation method suitable for individual end-user quality monitoring of IPTV services. With the proposed method, the activity values for individual given-size pixel blocks of an original video are transmitted to end-user terminals. At the end-user terminals, the video quality of a received video is estimated on the basis of the activity-difference between the original video and the received video. Psychovisual weightings and video-quality score adjustments for fatal degradations are applied to improve estimation accuracy. In addition, low-bit-rate transmission is achieved by using temporal sub-sampling and by transmitting only the lower six bits of each activity value. The proposed method achieves accurate video quality estimation using only low-bit-rate original video information (15kbps for SDTV). The correlation coefficient between actual subjective video quality and estimated quality is 0.901 with 15kbps side information. The proposed method does not need computationally demanding spatial and gain-and-offset registrations. Therefore, it is suitable for real-time video-quality monitoring in IPTV services.
Volcano‐earthquake interaction at Mauna Loa volcano, Hawaii (2006)

The activity at Mauna Loa volcano, Hawaii, is characterized by eruptive fissures that propagate into the Southwest Rift Zone (SWRZ) or into the Northeast Rift Zone (NERZ) and by large earthquakes at the basal decollement fault. In this paper we examine the historic eruption and earthquake catalogues, and we test the hypothesis that the events are interconnected in time and space. Earthquakes in the Kaoiki area occur in sequence with eruptions from the NERZ, and earthquakes in the Kona and Hilea areas occur in sequence with eruptions from the SWRZ. Using three‐dimensional numerical models, we demonstrate that elastic stress transfer can explain the observed volcano‐earthquake interaction. We examine stress changes due to typical intrusions and earthquakes. We find that intrusions change the Coulomb failure stress along the decollement fault so that NERZ intrusions encourage Kaoiki earthquakes and SWRZ intrusions encourage Kona and Hilea earthquakes. On the other hand, earthquakes decompress the magma chamber and unclamp part of the Mauna Loa rift zone, i.e., Kaoiki earthquakes encourage NERZ intrusions, whereas Kona and Hilea earthquakes encourage SWRZ intrusions. We discuss how changes of the static stress field affect the occurrence of earthquakes as well as the occurrence, location, and volume of dikes and of associated eruptions and also the lava composition and fumarolic activity.
Electronic structure of tetracoordinate transition-metal complexes. 2. Comparative theoretical ab initio/Hartree-Fock-Slater and UV-photoelectron spectroscopic studies of building blocks for low-dimensional conductors: glyoximate complexes of palladium(II) and platinum(II) (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic structure of tetracoordinate transition-metal complexes. 2. Comparative theoretical ab initio/Hartree-Fock-Slater and UV-photoelectron spectroscopic studies of building blocks for low-dimensional conductors: glyoximate complexes of palladium(II) and platinum(II)Santo Di Bella, Maurizio Casarin, Ignazio Fragala, Gaetano Granozzi, and Tobin J. MarksCite this: Inorg. Chem. 1988, 27, 22, 3993–4002Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November 1988https://pubs.acs.org/doi/10.1021/ic00295a020https://doi.org/10.1021/ic00295a020research-articleACS PublicationsRequest reuse permissionsArticle Views86Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A novel role of prostaglandin E2 in neuropathic pain (2010)

Neuropathic pain produced by damage to or dysfunction of the nervous system is a common and severely disabling state that affects millions of people worldwide. Recent evidence indicates that activated microglia are key cellular intermediaries in the pathogenesis of neuropathic pain and that ATP serves as the mediator. However, the in vivo mechanism underlying the retention of activated microglia in the injured region has not yet been completely elucidated. Prostaglandin E(2) (PGE(2)) is the principal proinflammatory prostanoid and plays versatile roles by acting via four PGE receptor subtypes, EP1-EP4. In the present study, we investigated the role of PGE(2) in spinal microglial activation in relation to neuropathic pain by using genetic and pharmacological methods. Mice deficient in microsomal prostaglandin E synthase-1 impaired the activation of microglia and the NMDA-nitric oxide (NO) cascade in spinal neurons in the dorsal horn and did not exhibit mechanical allodynia after peripheral nerve injury. The intrathecal injection of indomethacin, a nonsteroidal anti-inflammatory drug, ONO-8713, a selective EP1 antagonist, or 7-nitroindole, a neuronal NO synthase inhibitor, attenuated mechanical allodynia and the increase in activated microglia observed in the established neuropathic-pain state. We further demonstrated that ATP-induced microglial migration was blocked in vitro by PGE(2) via EP2 and by S-nitrosoglutathione, an NO donor. Taken together, the present study suggests that PGE(2) participated in the maintenance of neuropathic pain in vivo not only by activating spinal neurons, but also by retaining microglia in the central terminals of primary afferent fibers via EP2 subtype and via EP1-mediated NO production.
GEPIS—quantitative gene expression profiling in normal and cancer tissues (2004)

The email server version of the GEPIS application is freely available at http://share.gene.com/share/gepis. An interactive version of GEPIS will soon be freely available at http://www.cgl.ucsf.edu/Research/genentech/gepis/. The source code, modules, data and gene lists can be downloaded at http://share.gene.com/share/gepis.
Uncertainty sources analysis of a calibration system for the accuracy vs. temperature verification of voltage transformers (2018)

The paper deals with the investigation of accuracy vs. temperature variation of inductive instrument transformers. There is still a lack of literature on this specific and nowadays very important topic. In previous works, authors presented results on effects of temperature on voltage instrument transformers accuracy. In this paper the study continues with the uncertainty sources analysis which affects the calibration setup previously proposed. To this purpose, the metrological characterization along with the Monte Carlo method have been applied in order to highlight the main positive features of the calibration setup. Results of such procedures are presented.
<title>Error Diffusion Using Random Field Models</title> (1984)

Algorithms for bilevel display of continuous tone images should provide reproduction of edge detail and proper rendition of continuous tone regions with binary textures that adequately reproduce image gray scale without introducing additional structure into the image. Error diffusion algorithms have been shown to have the capability of generating visually appealing binary images, but existing schemes will sometimes generate undesirable textural artifacts. A new image binarization algorithm is developed based on a Markov random field texture model and an edge based constraint matrix. The resulting Markov random field error diffusion algorithm generates nondeterministic binary textures that overcome some of the problems associated with conventional binarization algorithms.
Quantitative Multiple-Quantum Magic-Angle-Spinning NMR Spectroscopy of Quadrupolar Nuclei in Solids (1996)

We describe a new approach for observation of multiple-quantum (MQ) NMR spectra of S = 3/2 nuclei with magic-angle spinning (MAS). The new method employs the Rotation-Induced Adiabatic Coherence Transfer (RIACT) that occurs between triple-quantum (3Q) and central-transition (1Q) coherences in S = 3/2 systems. In contrast to currently available coherence-transfer techniques, RIACT is relatively insensitive to the magnitude of the quadrupole interaction for e2qQ/h ≤ 4 MHz for both 3Q excitation and 3Q-to-1Q conversion. Thus, RIACT provides a means of extracting quantitative information about site populations from isotropic MQ NMR spectra. We illustrate the utility of the approach with 23Na (S = 3/2) MQ NMR spectra of a series of sodium salts exhibiting crystallographically distinct sites. The spectra provide quantitative measurements of quadrupolar parameters, chemical shifts, and relative site populations for each of the crystallographically distinct sodium sites.
Acute effects of brain-responsive neurostimulation in drug-resistant partial onset epilepsy (2021)

Identifying favorable stimulation related changes in iEEG activity could help physicians to more rapidly optimize stimulation settings for each patient.
QUÉTELET-TYPE INTERFERENCE FROM LIQUID CRYSTAL POLYMER DISPERSION FILMS (2004)

The Quételet-type ring pattern is observed in liquid crystal polymer dispersion (LCPD) films. The clusters of the polymer network and LC domains with different director axes in the LCPD films serve as scatterers. Changes in the first-order ring intensity are probed with a linearly polarized laser beam. Experimental results show that the first-order ring intensity of the Quételettype interference peaks when the polarization of the probe beam is parallel to the director axis of the LC molecules. Also, it is shown that the number of the scatterers, the order parameter of the liquid crystals and the applied electric field affect the ring intensities. A simple model is proposed to explain these observations.