gebhart/patrepeval huggingface dataset:
Multi-hop communication is order-optimal for homogeneous sensor networks (2004)

The main goal of this paper is to show that multi-hop single-user communication achieves the per node transport capacity of Θ(ln N<over>N) in homogeneous sensor networks, making it order-optimal. Our contributions in this paper are three-fold. First, we construct a route-discovery and scheduling scheme based on spatial TDMA for sensor networks. Second, we show that our schedule achieves a per node transport capacity of Θ(lnN<over>N), the same as that achievable by beamforming. Third, we compare multi-hop communication and beamforming based methods in terms of the network power consumption required to attain a fixed throughput. Based on our power calculations, we conclude that if the channel attenuation is above a certain threshold (which we calculate), then multi-hop communication performs better, whereas below the threshold, beamforming is preferable.
Pneumocystis jirovecii pneumonia after rituximab therapy for antibody‐mediated rejection in a renal transplant recipient (2008)

We report the case of a 54-year-old woman who underwent living-related renal transplantation for end-stage renal disease from IgA nephropathy. She was subsequently diagnosed with antibody-mediated rejection (AMR) and received rituximab, a potent B-cell suppressive agent. After therapy with rituximab, she developed Pneumocystis jirovecii pneumonia (PJP) requiring hospitalization. We discuss the increasing literature for the use of rituximab for AMR and the need for PJP prophylaxis in this setting.
Osteoprotegerin ameliorates sciatic nerve crush induced bone loss (2001)

This study examines the ability of osteoprotegerin (OPG) to prevent the local bone resorption caused by sciatic nerve damage. Sixty-five 18-week-old male mice were assigned to one of six groups (n = 10-11/group). A baseline control group was sacrificed on day zero of the 10-day study. The remaining groups were placebo sham operated, placebo nerve crush (Plac NC) operated, 0.1 mg/kg/day OPG + nerve crush (LOW), 0.3 mg/kg/day OPG + nerve crush (MED), and 1.0 mg/kg/day OPG + nerve crush (HI). Nerve crush or sham operations were performed on the right leg. The left leg served as a contralateral control to the nerve crushed (ipsilateral) leg. The difference in mass between the right and left femur and tibia was examined. Additionally, quantitative histomorphometry was performed on the right and left femur and tibia diaphyses. Nerve crush resulted in a significant loss of bone mass in the ipsilateral side compared to the contralateral side. Bone mass for the ipsilateral bones of the Plac NC group were significantly reduced by 3.8% in the femur and 3.5% in the tibia compared to the contralateral limb. The percent diminution was reduced for OPG treated mice compared to the Plac NC group for both the femur and tibia. In the femur, the percent reduction of ipsilateral bone mass was reduced to 1.0% (LOW), 1.3% (MED) and 1.6% (HI) compared to the contralateral limb. In the tibia, loss of bone mass in the ipsilateral limb was reduced to 1.4% (LOW), 1.4% (MED), and 2.4% (HI) compared to the contralateral. OPG also decreased the amount of tibial endocortical resorption compared to the Plac NC group. In summary, OPG mitigated bone loss caused by damage to the sciatic nerve.
Lipoprotein (a) is an Upstream Mediator of Aortic Stenosis (2022)

Background: A landmark genome-wide association study has linked mutations in the plasma lipoprotein complex lipoprotein(a) [Lp(a)] and aortic stenosis. We attempted to determine whether Lp(a) is a key upstream mediator of aortic stenosis. Methods: Male, Lp(a) transgenic (N=10) and control mice (N=10) were fed a high cholesterol diet for 6 weeks, then hearts were sectioned for histological analysis. Human stenosis (N=8) and non-stenotic (N=7) aortic valve leaflets were obtained intraoperatively and submitted for histologic and immunohistochemical analyses. All histological sections were semi-quantitatively graded in a blinded manner (0-3/3+ units). Results: Aortic valves from Lp(a) transgenic mice fed a high-cholesterol diet demonstrated significant aortic valve changes including fibrosis (2.0/4 vs 0.5/4), calcification (1.9.4 vs 0.1/4) units, angiogenesis (1.1/4 vs 0.3/4) and inflammatory infiltration (1.0 vs 0.1/4) compared with control aortic valves (all p&lt;0.001). Human stenotic aortic valve leaflets expressed greater Lp(a) (2.4/4 vs 1.7/4) in areas of fibrosis, inflammatory infiltration and angiogenesis, compared with non-stenotic aortic valve leaflets (p=&lt;0.005) Conclusion: Our proof-of-concept studies offer evidence for a potential causative role of Lp(a) as a trigger of aortic stenosis. Further work is needed to confirm these results. Therapeutic strategies targeting Lp(a) levels may serve as a novel strategy to limit progressive calcification in aortic stenosis.
Interplay between Magnetism and Magicness in Nanoclusters (2012)

Our experimental and theoretical investigation focuses on the role of magnetism on the structures and energetics of nanoclusters of the important 3d antiferromagnetic (AFM) semiconductor, manganese sulphide (MnS). Our cluster beam mass spectra for both (MnS)n and (MnSe)n show a pronounced “magic” abundance, at n = 13, in accord with results for other nonmagnetic chalcogenide clusters (e.g., CdS, CdSe, ZnS, ZnSe). Using global optimization and ab initio calculations we focus on cluster isomers of (MnS)13 and its two neighboring compositions, (MnS)12 and (MnS)14, and show that the magic status of the former is fully compatible with the high relative energetic stability of the n = 13 ground state with respect to those for n ± 1. We demonstrate a strong symbiosis between cluster structure and spin ordering, which leads to a particular type of AFM spin-ordered ground-state cluster structure being energetically selected for all cluster sizes and which enhances the magic stability of (MnS)13. This nanomagnetostructural effect highlights a fundamental link between magnetism and cluster structure having potential implications for (nano)technologies based on magnetostructural transitions (e.g., data storage, magnetic refrigeration).
Composition and properties of Finnish honey and their dependence on the season, region, bee race and botanical origin (1983)

Analyses were made of regionally representative samples of Finnish honey, 90 from 1977 and 68 from 1978. The average sugar composition, determined by thin layer chromatography, was: 47.3 % fructose, 43.9 % glucose and 8.7 % oligosaccharides. The ratio fructose/glucose was 1.1. Dry matter averaged 82.4 % and pH 3.9. Vitamin analysis of five sub samples gave 2700/µg/100 g ascorbic acid, 9/µg/ 100 g thiamine, 39 µg/ 100 g riboflavin and 1020/µg/100g niacin. The proportion of glucose was positively and the proportion of oligosaccharides negatively correlated to the count of Brassicaceae pollen in honey. The tendency to crystallize was explained better by the ratio glucose/oligosaccharides than by the ratios fructose/glucose, glucose/water or (glucose-water)/fructose. In sugar composition and in tendency to crystallize, seasonal and regional variation existed.
08292 Executive Summary – The Study of Visual Aesthetics in Human-Computer Interaction (2008)

This seminar explored various aspects of the study of visual aesthetics in human-computer interaction (HCI). The discussed issues relating to theory building, measurement issues, antecedents of aesthetic design and its consequences. We also identified a set of research challenges that this emerging field needs to discuss.
Dosimetry with 188Re-labelled monoclonal anti-CD66 antibodies (2006)

The proposed approach allows reliable prediction of biokinetics of (188)Re-labelled anti-CD66 monoclonal antibody biodistribution with a single study. Efficient pretherapeutic estimation of organ absorbed dose may be possible, provided that a more stable anti-CD66 antibody preparation is available.
Effect of intercalating ligands on the phosphorus-31 chemical shift of DNA (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of intercalating ligands on the phosphorus-31 chemical shift of DNARobert L. Jones and W. David WilsonCite this: J. Am. Chem. Soc. 1980, 102, 26, 7776–7778Publication Date (Print):December 1, 1980Publication History Published online1 May 2002Published inissue 1 December 1980https://pubs.acs.org/doi/10.1021/ja00546a023https://doi.org/10.1021/ja00546a023research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Application Of Angular Resolved Scatter To The Documentation Of Damage To Smooth Mirrors (1987)

Mirrors designed to survive exposure to damaging radiation are being irradiated and then measured to determine the mechanisms of failure and to improve the ability of analysis codes to predict an exposure damage threshold. The differences between survival and catastrophic failure are easily recognized and recorded by macro photography. However, the goal of this project is to quantify the onset of mirror degradation utilizing non contact methods that have good measurement sensitivity to small changes in reflectivity (material properties) and light scatter (roughness). A new angular resolved scatterometer is described that has an extended dynamic range and integrated analysis capable of displaying the surface power spectral density (PSD) over large bandwidths of surface spatial frequencies. Graphical displays of the scattered light power before and after exposure to the radiation are compared and integrated over equivalent spatial bandwidths of sensitivity for other instruments to compare calculated RMS roughness values.
Gene essentiality and synthetic lethality in haploid human cells (2015)

Although the genes essential for life have been identified in less complex model organisms, their elucidation in human cells has been hindered by technical barriers. We used extensive mutagenesis in haploid human cells to identify approximately 2000 genes required for optimal fitness under culture conditions. To study the principles of genetic interactions in human cells, we created a synthetic lethality network focused on the secretory pathway based exclusively on mutations. This revealed a genetic cross-talk governing Golgi homeostasis, an additional subunit of the human oligosaccharyltransferase complex, and a phosphatidylinositol 4-kinase β adaptor hijacked by viruses. The synthetic lethality map parallels observations made in yeast and projects a route forward to reveal genetic networks in diverse aspects of human cell biology.
Cross-Correlation Waveform Analysis for Conventional and Interferometric GNSS-R Approaches (2014)

Reflectometry using Global Navigation Satellite System (GNSS-R) signals has become an attractive tool for Earth remote sensing. Back to 1993, it was proposed as an alternative to the conventional spaceborne ocean altimetry to estimate the sea surface height over a large field-of-view. After Doppler compensation, the cross-correlation of the received scattered signal with either a locally generated replica [conventional GNSS-R (cGNSS-R)] or either the direct signal (interferometric GNSS-R (iGNSS-R)] is called the waveform. This paper provides a critical review of the cross-correlation waveform model, addressing issues such as the correlation characteristics, the bandwidth, the observation geometry, and the thermal and speckle noises. It provides a comprehensive and systematic overview of the impact of all these effects on the GNSS-R observables, which is important to properly define future GNSS-R instrument and mission concepts.
Reaction of atomic carbon with ethylene oxide. A MINDO/3 study of possible pathways (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of atomic carbon with ethylene oxide. A MINDO/3 study of possible pathwaysJuan M. Figuera, Philip B. Shevlin, and S. D. WorleyCite this: J. Am. Chem. Soc. 1976, 98, 13, 3820–3825Publication Date (Print):June 1, 1976Publication History Published online1 May 2002Published inissue 1 June 1976https://pubs.acs.org/doi/10.1021/ja00429a014https://doi.org/10.1021/ja00429a014research-articleACS PublicationsRequest reuse permissionsArticle Views39Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gender representation and histoire des mentalités : Language and Power in the Trésor de la langue française (1991)

Mark Olsen. Gender representation and histoire des mentalités : Language and Power in the Trésor de la langue française. The Trésor de la langue française (TLF) database of French literature is presented as an important source for systematic and quantitative analysis of the discourse underlying gender representation. The author argues that the symbolic elements of mentalité or collective attitudes can be examined diachronically using methods from quantitative lexicology and stylistics. Language is shown to encode power relations between the genders at the level of semantic fields surrounding very frequent words. The proposed semiotic approach to histoire des mentalités suggests that mentalité is an important element in the deployment of social power relations and that collective attitudes, as encoded in language, may persist to the present. Indeed, the nearly exclusively male composition of the TLF database indicates that the dictionary based on the TLF will serve as one mechanism for the continued gender marking of the French language.
Seeing Genes at Work in the Living Brain with Non-Invasive Molecular Imaging (2009)

Over the past ten years, a variety of imaging techniques have been developed that allow non-invasive detection of gene expression within the brain of intact mammals, ranging from mouse to man. The basic concepts of these imaging techniques, including positron emission tomography, single photon emission computed tomography, magnetic resonance imaging and spectroscopy, bioluminescence imaging and fluorescent imaging, are discussed. The expression of imaging reporter genes can be detected and quantified by these imaging techniques, which allow to unravel the temporospatial dynamics of gene expression within the intact living animal. Different imaging reporter genes have been developed each with their specific use in the basic and clinical neurosciences. Applications of reporter gene imaging can be found in neurooncology, infectious disease of the central nervous system, brain gene transfer, neural cellular therapy and in transgenic mice. Strategies that aim to image gene expression based on detection of mRNA levels have also been developed. We anticipate that these techniques will have a strong impact on preclinical neuroscience and will be of utmost importance in the implementation of gene and cell therapy for diseases of the brain.
Recommendations on ELISpot Assay Validation by the GCC (2022)

Gene therapy, cell therapy and vaccine research have led to an increased need to perform cellular immunity testing in a regulated environment to ensure the safety and efficacy of these treatments. The most common method for the measurement of cellular immunity has been Enzyme-Linked Immunospot assays. However, there is a lack of regulatory guidance available discussing the recommendations for developing and validating these types of assays. Hence, the Global CRO Council has issued this white paper to provide a consensus on the different validation parameters required to support Enzyme-Linked Immunospot assays and a harmonized and consistent approach to Enzyme-Linked Immunospot validation among contract research organizations.
Active browsing with similarity pyramids (2002)

Many approaches to content based retrieval of images have focused on query-by-example methods in which the database is searched for all images similar to an example image presented by the user. However query-by-example techniques tend to quickly converge to a small set of images that may not be of interest. In this paper we present an alternative method for content based search which is based on active browsing using a data structure called a similarity pyramid. The similarity pyramid organizes large databases into a three dimensional pyramid structure which the user can move through. During the browsing process, the user can give feed-back through the selection of a set of desirable images which we call a relevance set. Once selected the relevance set can be used to both prune and reorganize the similarity pyramid to best suit the user's task. A novel cross-validation method is also proposed for effectively performing pruning and reorganization operations.
Deep Convolutional Encoder-Decoder Framework for Fetal ECG Signal Denoising (2019)

Non-invasive fetal electrocardiography has the potential of providing vital information for evaluating the health status of the fetus. However, the low signal to noise ratio of the fetal electrocardiogram (ECG) impedes the applicability of the method in clinical practice. Residual noise in the fetal ECG, after the maternal ECG is suppressed, is often non-stationary, complex and has spectral overlap with the fetal ECG. We present a deep fully convolutional encoder-decoder framework, for removing the residual noise from single-channel fetal ECG. The method was tested in a broad simulated fetal ECG dataset with varying amount of noise. The results demonstrate that after the denoising there was an average increase in the correlation coefficient between the corrupted signals and the original ones from 0.6 to 0.8. Moreover, the suggested framework successfully handled different levels of noises in a single model. The network was further tested on real signals showing substantial noise removal performance, thus providing a promising approach for fetal ECG signal denoising. The presented method is able to significantly improve the quality of the extracted fetal ECG signals, having the advantage of preserving beat-to-beat morphological variations.
Round Trip Radical Reactions from Acyclic Precursors to Tricyclo[5.3.1.02,6]undecanes. A New Cascade Radical Cyclization Approach to (±)-Isogymnomitrene and (±)-Gymnomitrene (2000)

The synthesis and "round trip radical cyclization" of 11-iodo-2,7,11-trimethyldodec-6-en-5-one are described. The round trip cyclization is a sequence of 5-exo, 6-endo, and 5-exo cyclizations in which the last radical cyclization occurs at the same carbon atom as the initial radical generation. The key second (6-endo) cyclization produces two stereoisomers, one of which cyclizes efficiently to isogymnomitrene ketone, while the other cyclizes inefficiently to gymnomitrene ketone. Efforts to influence the kinetic or thermodynamic outcome of the second cyclization were not successful, and the results are contrasted with a related cyclization of Jung and Rayle where thermodynamic control was readily established.
Development of stable flocculent Saccharomyces cerevisiae strain for continuous Aspergillus niger β-galactosidase production (2007)

A flocculent Saccharomyces cerevisiae strain was engineered to stably secrete Aspergillus niger beta-galactosidase in a continuous high-cell-density bioreactor. The delta-sequences from the yeast retrotransposon Ty1 were used as target sites for the integration of the beta-galactosidase expression cassette. High-copy-number transformants were successfully obtained using the delta-integration system together with the dominant selection antibiotic, G418. The integration of multiple copies was confirmed by genomic Southern blot analysis. Integrants with the highest beta-galactosidase levels (approximately eight gene copies) had similar beta-galactosidase activities as a recombinant strain carrying the beta-galactosidase expression cassette in a YEp-based vector. The beta-galactosidase expression cassettes integrated into the yeast genome were stably maintained after eight sequential batch cultures in a nonselective medium. In continuous high-cell-density culture under the same operating conditions, the integrant strain was more stable than the plasmid-carrying strain. To our knowledge, this is the first study of multicopy delta-integrant stability in a continuous bioreactor operating at different dilution rates.
New head gradient coil design and construction techniques (2013)

The ability to adapt an electromagnetic design to necessary changes from an engineering perspective leads to superior coil performance.
Cationic photoimmunoconjugates between monoclonal antibodies and hematoporphyrin: selective photodestruction of ovarian cancer cells (1998)

The photosensitizer hematoporphyrin (HP) was site specifically attached to a murine monoclonal antibody (MAb) fragment OC125F(ab?)(2) directed against ovarian cancer cells and to nonspecific rabbit immunoglobulin G. The photoimmunoconjugates were positively charged and were purified by column chromatography. The OC125F(ab?)(2) conjugate retained immunoreactivity with human ovarian cancer cells, and the binding was competed with unmodified MAb. Phototoxicity paralleled the cellular uptake with the OC125F(ab?)(2) conjugate and the light showing selective killing of target cells compared with nontarget cells. Nontargeted conjugates and free HP produced lower levels of phototoxicity and showed no selectivity.