gebhart/patrepeval huggingface dataset:
A 2:1 MUX Based on Multiple MEMS Resonators (2016)

Micro/nano-electromechanical resonator based mechanical computing has recently attracted significant attention. This paper reports a realization of a 2:1 MUX, a concatenable digital logic element, based on electrothermal frequency tuning of electrically connected multiple arch resonators. Toward this, shallow arch shaped microresonators are electrically connected and their resonance frequencies are tuned based on an electrothermal frequency modulation scheme. This study demonstrates that by reconfiguring the same basic building block, the arch microresonator, complex logic circuits can be realized.
Development of ZnO Based Charged Particle Monitor for Processing Facility (2011)

In the present paper, we describe the development of an α-ray imaging detector based on a ZnO single crystalline scintillator and a position-sensitive photomultiplier tube (PSPMT). The ZnO crystal was grown by the hydrothermal synthesis method with 2-in.-φ in diameter. The ZnO specimen was polished out to be 0.5 mm in thickness. After optically coupling with PSPMT, the crystal was irradiated with 241 Am α-ray for evaluation of both spatial resolution and pulse height spectrum. Using the charge center of the gravity method, two-dimensional α-ray images were successfully obtained. The efficiency of the energy window in terms of imaging quality was also examined.
Biomedical Applications: Ultrasound‐Induced Wireless Energy Harvesting for Potential Retinal Electrical Stimulation Application (Adv. Funct. Mater. 33/2019) (2019)

In article number 1902522, Yang Yang, Jianguo Zhu, Yong Chen, Qifa Zhou, and co-workers demonstrate a potential retinal electrical stimulation strategy using ultrasound-driven wireless energy harvesting technology through a millmeter-scale lead-free ultrasonic energy harvesting device. The as-developed device is flexible and can be attached on a complex surface and be driven by ultrasound to produce adjustable electrical outputs.
Rapid Cloning and Validation of MicroRNA Shuttle Vectors: A Practical Guide (2011)

MicroRNAs (miRNAs) have emerged as important modulators of eukaryotic gene expression through a process called RNA interference (RNAi). Over the last several years, a large amount of work has focused on understanding how miRNAs are expressed and processed to a biologically functional form. This knowledge has enabled the development of RNAi as a molecular tool for investigating basic biological questions or as a therapeutic technique. Artificial miRNA shuttle vectors can be engineered to mimic natural miRNAs and subsequently used to suppress any gene of interest. Here, we describe a simple method to build and functionally validate artificial miRNA shuttles.
Active sites in char gasification. Quarterly technical progress report, 1 January-31 March 1986. [Lignite char and phenolic resin char] (1986)

This project is concerned with the study of the nature and behavior of ''active sites'' in the gasification of chars produced from synthesized model compounds, primarily those of the phenol-formaldehyde family of resins. Of the various techniques that have been identified to accomplish the objectives of this project, the development of a reliable measure of the total active surface area (TASA) of the chars is one of the most important. The primary technique that has been pursued in the current work is O/sub 2/ chemisorption. In the present quarter, we have looked more closely at the question of what precisely is being measured by the oxygen chemisorption technique. We have been particularly concerned with the myriad of conditions employed to characterize TASA, and how these somewhat arbitrarily chosen conditions can affect what is reported as TASA. There is, in particular, a concern that ''young chars'' may behave quite differently from ''old chars,'' and that the mechanism of oxygen chemisorption is quite different on a hydrogen-rich char as opposed to a hydrogen-poor char. The project will focus much more closely in the future on issues of mechanism of chemisorption, and how these may or may not relate to the practical problemsmore » of estimating char combustion and/or gasification reactivity. In this report, we present a brief summary of relevant literature in the area and describe some tests that have been performed to highlight the nature of the problem, and to show that the conclusions are largely the same regardless of whether we consider our well-defined model chars, or an actual coal char. 42 refs., 2 figs., 1 tab.« less
Identification of isomeric N-glycan structures by mass spectrometry with 157 nm laser-induced photofragmentation (2008)

Characterization of structural isomers has become increasingly important and extremely challenging in glycobiology. This communication demonstrates the capability of ion-trap mass spectrometry in conjunction with 157 nm photofragmentation to identify different structural isomers of permethylated N-glycans derived from ovalbumin without chromatographic separation. The results are compared with collision-induced dissociation (CID) experiments. Photodissociation generates extensive cross-ring fragment ions as well as diagnostic glycosidic product ions that are not usually observed in CID MS/MS experiments. The detection of these product ions aids in characterizing indigenous glycan isomers. The ion trap facilitates MS(n) experiments on the diagnostic glycosidic fragments and cross-ring product ions generated through photofragmentation, thus allowing unambiguous assignment of all of the isomeric structures associated with the model glycoprotein used in this study. Photofragmentation is demonstrated to be a powerful technique for the structural characterization of glycans.
Mechanism of the Fe3+ Reduction at Low Temperature for LiFePO4 Synthesis from a Polymeric Additive (2007)

Comparison is made between the use of either a carbon powder or a polymer additive to the precursors in the synthesis of LiFePO4 from the Fe(III) compound FePO4(H2O)2 and Li2CO3. The evolution of the structural properties and phase purity with temperature and time have been monitored at all length scales by X-ray diffraction, Fourier transformed infrared spectroscopy, and magnetic susceptibility. The reactor temperature was decreased to 300 °C to investigate the early stages of the reaction. Formation of crystalline LiFePO4 begins in the range 300−400 °C only if the polymer is used as the carbonaceous additive. This LiFePO4 formation is made possible by the reduction of Fe(III) species by gases such as H2 or gaseous hydrocarbons evolved during the calcination of the polymer. Moreover, decomposition of the polymer results in a carbonaceous deposit on the surface of the LiFePO4 particles. An Li3Fe2(PO4)3 impurity found after sintering at 400 °C for 4 h was greatly reduced after sintering at 400 °C for 24 h, and phase-pure LiFePO4 was attained at 700 °C. Where the solid carbon powder was used as the reducing agent, no Fe(II) species could be detected after sintering at 400 °C. Carbothermal reduction of Fe(III) is ruled out in this temperature range.
A dual-level matching algorithm for 3-stage Clos-network packet switches (2004)

In this paper, we present a new dual-level matching algorithm for 3-stage Clos-network packet switches, called d-MAC. Using a two-level matching algorithm, namely module-level matching and port-level matching, d-MAC is highly scalable and maintains high system performance. The module-level matching is responsible for finding the module-to-module matching according to the queue status of the switch, while the port-level matching is responsible for determining port-to-port matching and route assignment simultaneously. The two-level matchings are computed in a pipelined and parallel manner to speed up packet scheduling.
CCDC 1852214: Experimental Crystal Structure Determination (2008)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
In Situ Polymerized Wicks for Passive Water Management and Humidification of Dry Gases (2009)

We develop a passive water management system that employs in-situ polymerized wick structures that can be integrated with state-of-the-art flow field designs (e.g., stamped metal or injection molded). We develop a simple model to examine the feasibility of using a pre-humidifier to evaporate fuel cell product water into the cathode inlet dry-gas stream. We then demonstrate the effectiveness of this idea in a custom-fabricated integrated wick system. We also experimentally study the performance of our novel wick design for flood mitigation in a parallel flow field using fully humidified gases.
The Synthesis of Poly(Dimethylsiloxane-b-Isobutylene-b-Dimethylsiloxane) and Poly-(Dimethylsiloxane-b-Isobutylene-b-Dimethylsiloxane) from Alcohol-Telechelic Polyisobutylenes (1987)

Abstract The purpose of these studies was to combine polydimethylsiloxane (PDMS) and polyisobutylene (PIB) sequences into novel triblock, PDMS-b-PIB-b-PDMS, and multiblock, (-PDMS-b-PIB-b-PDMS-)n, copolymers. The key toward syntheses was the definition of conditions for the initiation of living anionic polymerization of hexamethyl-cyclotrisiloxane (D3) at the CH2OLi termini of well-defined tele-chelic PIB sequences. Subsequent deactivation of living D3 polymerization charges with Me3 SiCl yielded the target triblock whereas stoichiometric amounts of Me2 SiCl2 gave the multiblock copolymer.
Practical Channel Splicing using OFDM Waveforms for Joint Communication and Sensing in the IoT (2023)

Channel splicing is a rather new and very promising concept. It allows to realize a wideband channel sounder by combining multiple narrow-band measurements. Among others, channel splicing is a sparse sensing techniques suggested for use in joint communication and sensing (JCAS), channel measurements and prediction using cheap hardware that cannot measure wideband channels directly such as in the internet of things (IoT). This work validates the practicality of a channel splicing technique by integrating it into an OFDM-based IEEE 802.11ac system, which we consider representative for many IoT solutions. Our system allows computing both the channel impulse response (CIR) and the channel frequency response (CFR). In this paper, we concentrate on the impact of the number of sub-bands in our study and show that even using only 50% of the overall spectrum leads to very accurate CIR measures. We validate the system in simulation and confirm the results in an experimental in-door scenario using software defined radios.
Direct Observation of the Conical Intersection in cis-trans Photoisomerization of Rhodopsin (2009)

High-time-resolution broadband pump-probe spectroscopy of rhodopsin reveals the loss of reactant and appearance of photoproduct features within ≈100fs, which are signatures of a wavepacket moving through a conical intersection. Experiments are supported by molecular dynamics simulations.
DrugCentral: online drug compendium (2016)

DrugCentral (http://drugcentral.org) is an open-access online drug compendium. DrugCentral integrates structure, bioactivity, regulatory, pharmacologic actions and indications for active pharmaceutical ingredients approved by FDA and other regulatory agencies. Monitoring of regulatory agencies for new drugs approvals ensures the resource is up-to-date. DrugCentral integrates content for active ingredients with pharmaceutical formulations, indexing drugs and drug label annotations, complementing similar resources available online. Its complementarity with other online resources is facilitated by cross referencing to external resources. At the molecular level, DrugCentral bridges drug-target interactions with pharmacological action and indications. The integration with FDA drug labels enables text mining applications for drug adverse events and clinical trial information. Chemical structure overlap between DrugCentral and five online drug resources, and the overlap between DrugCentral FDA-approved drugs and their presence in four different chemical collections, are discussed. DrugCentral can be accessed via the web application or downloaded in relational database format.
Electrical characterization of FinFETs with fins formed by directed self assembly at 29 nm fin pitch using a self-aligned fin customization scheme (2014)

In this work, we report electrical characterization FinFET devices with 29nm-pitch fins patterned using a technique called tone inverted grapho-epitaxy (TIGER). We use a topographic template to direct the self-assembly of block copolymers (BCP) to form small area gratings that are self-aligned to the template. After a tone-inversion operation, blocks of defect free SOI fins bounded by self-aligned exclude regions are formed with the spacing determined by the template line width (LW). This self-aligned customization enables further definition of the active region for FinFETs. Process window and design implications for directed self-assembly (DSA) with TIGER are also discussed.
New Linearizer Channel Amplifier family designed to optimize TWT operation (2008)

This paper presents a complete new family of Linearizer / Channel Amplifier designed to further optimize the Traveling Wave Tube (TWT) operation by providing close-to-ideal TWT linearization and offering new features improving TWT operating point management. The building block approach allows to handle a rich portfolio of needs from C to Ka band, with all known ground command and telemetry interface formats. Designs can also readily be adjusted to specific mechanical interface constraints while remaining compatible with mass production to cope with the sharp growth of the telecommunications satellite demand.
Speed Optimized Implementations of the QUAD Algorithm. (2013)

Abstract not provided.
Effects of Room Temperature Heavy-Ion Irradiation on Magnetic and Electrical Properties of a Single Crystalline Iron Thin Film (2009)

We investigated the magnetic and electrical properties of a heavy-ion irradiated single crystalline iron film. A high quality Fe (001) film on MgO (001) was fabricated using the molecular beam epitaxy technique. The iron film was treated by 3.2 MeV Ni ion irradiation at room temperature using a tandem accelerator. Although the residual electrical resistivity increased by 0.9×10−8 Ωm after ion irradiation, the M-H curves did not change significantly. These results indicate that the formation of small irradiation defects such as sub-nanometer size vacancy clusters has little influence on magnetocrystalline anisotropy and the magnetization process of iron.
Quantum walks and wavepacket dynamics on a lattice with twisted photons (2015)

The "quantum walk" has emerged recently as a paradigmatic process for the dynamic simulation of complex quantum systems, entanglement production and quantum computation. Hitherto, photonic implementations of quantum walks have mainly been based on multipath interferometric schemes in real space. We report the experimental realization of a discrete quantum walk taking place in the orbital angular momentum space of light, both for a single photon and for two simultaneous photons. In contrast to previous implementations, the whole process develops in a single light beam, with no need of interferometers; it requires optical resources scaling linearly with the number of steps; and it allows flexible control of input and output superposition states. Exploiting the latter property, we explored the system band structure in momentum space and the associated spin-orbit topological features by simulating the quantum dynamics of Gaussian wavepackets. Our demonstration introduces a novel versatile photonic platform for quantum simulations.
Hardness of decoding quantum stabilizer codes (2013)

In this article we address the computational hardness of optimally decoding a quantum stabilizer code. Much like classical linear codes, errors are detected by measuring certain check operators which yield an error syndrome, and the decoding problem consists of determining the most likely recovery given the syndrome. The corresponding classical problem is known to be NP-complete, and a similar decoding problem for quantum codes is also known to be NP-complete. However, this decoding strategy is not optimal in the quantum setting as it does not take into account error degeneracy, which causes distinct errors to have the same effect on the code. Here, we show that optimal decoding of stabilizer codes is computationally much harder than optimal decoding of classical linear codes, it is #P.
Three-dimensional myocardial deformations: calculation with displacement field fitting to tagged MR images. (1995)

The combination of rapidly acquired parallel-tagged MR images and field-fitting analysis is a valuable tool in cardiac mechanics research and in the clinical assessment of cardiac mechanical function.
Gas Condensate Relative Permeabilities in Propped Fracture Porous Media: Coupling Versus Inertia (2008)

Abstract Hydraulic fracturing is one of the most common well stimulation techniques for gas-condensate reservoirs. In recent years considerable effort has been directed towards understanding of flow around hydraulically fractured wells especially for tight gas reservoirs. However, there has been no report of a study of flow behaviour within propped fractured porous media for these low interfacial tension (IFT) systems. It is now a well established finding both experimentally and theoretically that the flow of gas-condensate fluid systems in porous media is affected by both coupling (the increase of relative permeability (kr) as velocity increases and/or IFT decreases) and inertial (i.e., the reduction of kr as velocity increases) effects. However, the interaction of capillary, viscous and inertial forces within highly conductive propped fractures is yet unknown. In this work, we report a series of steady state gas-condensate relative permeability values for a proppant filled and a sand packed fracture with permeability of 146 D and 15 D, respectively. These sets of kr data, which have been measured using our unique experimental facilities, covers IFT and velocity values ranging between 0.85 and 0.15 mNm−1 and 250 to 3000 md−1, respectively. The results indicate that inertia is quite dominant at all the tested conditions albeit to a greater extent at lower IFT and higher gas fractional flow rates. In the case of the fracture with the higher permeability, some kr values measured at the higher IFT are also reported, which are higher than the corresponding values at a lower IFT. We also compare the results with the corresponding predicted kr values by the generalized kr correlation, which we reported recently and expresses the combined effect of coupling and inertia with universal parameters. The unique contribution of inertial forces, as observed in the experiments and predicted by the correlation, is mainly attributed to the impact of the fracture properties and the fluid flowing in the fractures.
Resolving high flow-induced vibrations (2010)

Atia Khalifa, Amro Al-Qutub and Yehia Khulief of Saudi Arabia's King Fahd University of Petroleum & Minerals present a case history in which problematic high flow-induced vibration in a boiler feed pump was studied and corrected. A combination of field measurements and lab model testing identified the source of the problem.
Biocompatibility of Alkyl and Perfluoroalkyl Telomeric Surfactants Derived from Tham (1993)

A preliminary, comparative biological evaluation of two new families of non-ionic telomeric surfactants derived from Tris(hydroxymethyl)acrylaminomethane (THAM) is reported. These trisacryl conjugates, or TAC, were designed with the purpose of improving the stability and biocompatibility of fluorocarbon emulsions to be used in injectable oxygen-delivering systems. Their amphiphilic character arises from the simultaneous presence in the same molecule of several hydrophilic THAM residues and of a hydrophobic tail consisting in either a hydrocarbon (H-TAC family) or a fluorocarbon (F-TAC family) chain. The acute toxicity in mice after intravenous injection is low (LD50 in the 625 to 1250 mg/kg body weight range for the H-TAC compared to 630 to 4500 mg/kg body weight range for F-TAC) and increases with the length of the hydrophobic chain. No hemolytic activity was detected for the F-TAC at concentrations up to 200 g/l, while hemolysis is found for the H-TAC at a concentration of 5 g/l or less and increases with the alkyl chain length. The impact of the new surfactants on the growth and viability of Namalva cell cultures also increases with the length of the hydrophobic chain, with again a better tolerance for the F-TAC. Altogether the fluorinated amphiphiles display better tolerance than their hydrocarbon analogs in spite of their significantly increased surface activity. Both families of compounds appear to have potential as strongly hydrophilic surfactants for biomedical applications.
Electronic Structures of Halogenated Ruthenium Porphyrins. Crystal Structure of RuTFPPCl8(CO)H2O (TFPPCl8 = Octa-.beta.-chlorotetrakis(pentafluorophenyl)porphyrin) (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic Structures of Halogenated Ruthenium Porphyrins. Crystal Structure of RuTFPPCl8(CO)H2O (TFPPCl8 = Octa-.beta.-chlorotetrakis(pentafluorophenyl)porphyrin)Eva R. Birnbaum, William P. Schaefer, Jay A. Labinger, John E. Bercaw, and Harry B. GrayCite this: Inorg. Chem. 1995, 34, 7, 1751–1755Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/ic00111a023https://doi.org/10.1021/ic00111a023research-articleACS PublicationsRequest reuse permissionsArticle Views265Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Development of Novel Glucocorticoids for Use in Antibody–Drug Conjugates for the Treatment of Inflammatory Diseases (2021)

Glucocorticoids (GCs) are widely used to treat a variety of autoimmune and inflammatory diseases; however, systemic delivery of GCs is associated with side effects that affect essentially every organ system, reflecting the nearly ubiquitous expression of the glucocorticoid receptor (GR). Targeted delivery of GCs to diseased tissues using antibody-glucocorticoid conjugates (GC-ADCs) offers a therapeutic alternative to overcome these adverse effects. Herein, we describe novel classes of GCs that exhibited greater potency than dexamethasone and budesonide, a 100-fold selectivity toward the GR over other nuclear receptors, and no <i>in vitro</i> safety liability in pharmacology assays (hERG, AMES) and that demonstrated a substantial reduction in tumor necrosis factor-α (TNF-α) release in mice challenged with lipopolysaccharide (LPS). The site-specific conjugated GC-ADCs via cathepsin-cleavable linkers were highly stable in plasma and specifically released GCs in antigen-positive cells, suggesting that these novel GCs can serve as ADC payloads to treat autoimmune and inflammatory diseases.