gebhart/patrepeval huggingface dataset:
Beneficial effects of a pyrroloquinolinequinone-containing dietary formulation on motor deficiency, cognitive decline and mitochondrial dysfunction in a mouse model of Alzheimer’s disease (2017)

Alzheimer's disease (AD), a progressive neurodegenerative disorder, is linked to oxidative stress, altered amyloid precursor protein (APP) proteolysis, tau hyperphosphorylation and the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles (NFT). A growing body of evidence suggests that mitochondrial dysfunction can be a key promoter of all of these pathologies and predicts that restoration of mitochondrial function might be a potential therapeutic strategy for AD. Therefore, in the present study, we tested the beneficial effect of a nutraceutical formulation Nutrastem II (Nutra II), containing NT020 (a mitochondrial restorative and antioxidant proprietary formulation) and pyrroloquinolinequinone (PQQ, a stimulator of mitochondria biogenesis) in 5XFAD transgenic mice. Animals were fed Nutra II for 12 weeks, starting at 3 months of age, after which behavioral and neuropathological endpoints were determined. The data from behavioral test batteries clearly revealed that dietary supplementation of Nutra II effectively ameliorated the motor deficiency and cognitive impairment of 5XFAD mice. In addition, Nutra II also protected mitochondrial function in 5XFAD mice brain, as evidenced by declined ROS levels and membrane hyperpolarization, together with elevated ATP levels and respiratory states. Interestingly, while Nutra II treatment only slightly reduced soluble Aβ<sub>42</sub> levels, this formulation significantly impacted tau metabolism, as shown by reduced total and phosphorylated tau levels of 5XFAD mouse brain. Taken together, these preclinical findings confirm that mitochondrial function may be a key treatment target for AD and that Nutra II should be further investigated as a potential candidate for AD therapy.
Cycle life prediction for lithium-ion battery based on GM(1, N) grey model (2015)

The accurate prediction of battery life has an important effect on the safe and reliable operation of electric vehicles. The decline of capacity and the increase of resistance indicate the decay of battery life. This paper considers comprehensively the change trends of battery capacity and battery internal resistance, and proposes a battery life prediction model based on GM(1, N) grey theory. The validity of the proposed prediction model is verified by experiments and simulation. The maximum prediction error of the model is less than 30 mAh, and the mean relative error is less than 0.071. GM(1, N) model has the higher prediction accuracy and good robustness than the traditional GM(1,1) model that only considers battery internal resistance. By accurate cycle life prediction, the attenuation trends of battery capacity are acquired, and the accidents caused by invalid batteries are effectively avoided.
Minimum-time trajectory planning for industrial robots with general torque constraints (1985)

http://deepblue.lib.umich.edu/bitstream/2027.42/7585/5/bad2123.0001.001.pdf
Experimental demonstration of robustness and accuracy of a DLI-based OSNR monitor under changes in the transmitter and link for different modulation formats and baud rates (2015)

We experimentally studied the performance of a delay-line interferometer-based optical signal-to-noise ratio (OSNR) monitor that is pre-calibrated in optimal conditions for 25-Gbaud pol-muxed quadrature-amplitude-modulation (QAM) signals, when unpredicted changes outside the monitor occurred either in the transmitter or the link.
Subcarrier polarization manipulation using orthogonal dual phase-modulation in fiber (2016)

S.27-29
Supplementary Figure 1 from ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment (2023)

&lt;p&gt;PDF file - 312K&lt;/p&gt;
Thermophysical Characterization of Sorption TCM (2014)

Thermochemical materials (TCM) are proposed for thermal energy storage as one of the future options to achieve lower energy consumption in buildings and other industrial applications, as well as to store energy from solar energy. In this study, the thermophysical properties of two TCM, CaCl2 and zeolite, are determined with TGA and DSC and samples are cycled 4 times with TGA. Results show that the material with the highest energy density is the salt, CaCl2. Moreover, both materials under study present noble cyclability.
Phosphorus-Species-Induced Band-Gap Anomaly in InGaP Grown by Solid-Source Molecular-Beam Epitaxy (2001)

We report on the growth of InGaP by solid-source molecular-beam epitaxy. It is revealed by photoluminescence (PL) that a lower effective band-gap energy appeared when a higher phosphorus cracker temperature was used. Temperature-dependent PL and polarized photoreflectance (PR) also exhibited a weaker atomic ordering effect when the phosphorus cracker temperature increased. Since the variation of the phosphorus cracker temperature significantly changed the P 2 /P 4 ratio, we believe that a more chemically reactive P 2 will not only incorporate more In atoms into the epilayer, but will also bring about a smaller composition fluctuation and weaker ordering effect. Therefore, InGaP grown under a more P 2 -rich condition probably has a higher In content which results in a lower band-gap energy instead of the ordering effect.
THE EFFECTS OF ANIONIC POLAR AND ZWITTERIONIC PHOSPHOLIPIDS ON THE TEAR FILM LIPID LAYER. (2000)

Third International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance: Maui, Hawaii; November 15-18, 2000: Abstracts
Optimisation of photonic crystal coupling through waveguide design (2017)

This paper considers multiple structural designs for photonic crystal surface emitting lasers operating at key wavelengths. Initially a structure from Williams et al. is modelled, the structure is modified to include an additional GaAs waveguide layer (termed ballast layer) and to include an additional PC layer (termed double decker). These structures are modelled by a combination of coupling calculation and waveguide modelling and are compared to the original structure. We show that both of these schemes give an increase in coupling, but present fabrication challenges. Next, we model standard laser structures operating at key wavelengths (400 nm, 1.3 and 10 µm) where a photonic crystal is located above the active region and explore the effect of increasing thickness of photonic crystal. We find that increasing the thickness increases the coupling coefficient but not true for the full range of thicknesses considered. This study allows a more universal comparison of the use of all-semiconductor, or void containing PCSELs to be conducted and we find that the realisation of all semiconductor PCSELs covering a wide range of material and wavelengths are possible.
Supplementary Figure 2 from First Evidence of Sphingosine 1-Phosphate Lyase Protein Expression and Activity Downregulation in Human Neoplasm: Implication for Resistance to Therapeutics in Prostate Cancer (2023)

&lt;p&gt;PDF file, 107K, The modulation of S1P content in C4-2B prostate cancer cells alters sensitivity to irradiation.&lt;/p&gt;
Development of a Cuvette-Based LSPR Sensor Chip Using a Plasmonically Active Transparent Strip (2019)

This research demonstrates the development of a transmission-mode localized surface plasmon resonance (LSPR) sensor chip using a cuvette cell system for the sensitive detection of a biomolecule marker such as C-reactive protein (CRP). In order to develop a highly sensitive LSPR sensor chip, plasmonically active gold nanoparticles (AuNPs) were decorated onto various transparent substrates in the form of a uniform, high-density single layer using a self-assembly process. The transparent substrate surface was modified with amine functional groups via (3-Aminopropyl)triethoxysilane (APTES) treatment, and the ligand concentration and temperature (0.5% APTES at 60°C) were then optimized to control the binding energy with AuNPs. The optimized plasmonically active strip was subsequently prepared by dipping the amine-functionalized substrate into AuNPs for 8 h. The optimized plasmonic strip functionalized with anti-CRP was transformed into a portable LSPR sensor chip by placing it inside a cuvette cell system, and its detection performance was evaluated using CRP as a model sample. The detection limit for CRP using our LSPR sensor chip was 0.01 μg/mL, and the detection dynamic range was 0.01-10 μg/mL with a %CV of <10%, thus confirming its selectivity and good reproducibility. These findings illustrate that the highly sensitive portable LSPR biosensor developed in this study is expected to be widely used in a diverse range of fields such as diagnosis, medical care, environmental monitoring, and food quality control.
Automotive LiDAR based on Geiger-mode sensors (Conference Presentation) (2018)

Avalanche photodiodes operated in Geiger mode provide single-photon detection with excellent timing accuracy on a scalable semiconductor device platform, and they have been shown to enable high-rate collection of 3D LiDAR imagery from airborne platforms at extremely long (>10 km) stand-off distances. More recently, we have applied Geiger-mode technology to shorter range LiDAR systems designed for high-performance, low-cost automotive applications. The combination of two factors-single-photon sensitivity and the greater eye-safety of lasers at wavelengths beyond 1400 nm-provides disruptive automotive LiDAR range and resolution that will be essential to future autonomous vehicle navigation.
ChemInform Abstract: Synthesis and Biological Evaluation of 6‐Carboxy‐3,4‐methanoprolines, New Rigid Glutamate Analogues. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Studies of high-current relativistic electron beam interaction with gas and plasma in Novosibirsk (2016)

This paper presents an overview of the studies on the interaction of a high-power relativistic electron beam (REB) with dense plasma confined in a long open magnetic trap. The main goal of this research is to achieve plasma parameters close to those required for thermonuclear fusion burning. The experimental studies were carried over the course of four decades on various devices: INAR, GOL, INAR-2, GOL-M, and GOL-3 (Budker Institute of Nuclear Physics) for a wide range of beam and plasma parameters.
Effect of tangential misalignment in ultrasonic burnishing (2019)

Ultrasonic burnishing is a surface finishing process that produces fine surface roughness, improved geometrical accuracy, high compressive residual stresses and increased hardness. The method is suitable for finishing dies or other double curvature surfaces and it does not require changing of the fixturing setup after a machining process. The method has not however become commonly used in industry, because the technology has not been extensively tested. Technological parameters in ultrasonic burnishing includes the surface speed, distance between consecutive passes (or in machining terms, feed) and contact force. Ultrasonic burnishing is based on forging at an ultrasonic frequency of over 20,000 impacts per second and there is no material removal associated with the process. The technological parameters have been tested and recommended values have been recorded for some common work materials. One important parameter is the tangential alignment of the burnishing tool in regard to the workpiece surface normal. This parameter is easy to control in turning operations or with planar surfaces, but with a double curved surface the control of the angle is more difficult. All the previous research has been done on cylindrical or planar workpiece and therefore the tangential misalignment or the sensitivity of the surface integrity regarding the tangential misalignment has not been studied. This paper investigates the effect of the tangential misalignment of the burnishing tool and the effect on surface integrity. The results show that ultrasonic burnishing is suitable method for finishing workpiece surfaces even with inclined tool angle. The ultrasonic burnishing produced a beneficial surface integrity state on the workpiece surface with hardened material and improved surface quality. The surface micro-hardness increased by 1.4-6.7 %. At the same time, the average surface roughness (Ra) values decreased by 50-85 % depending on the misalignment angle.
STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer (2022)

Abstract PARP inhibitors (PARPi) have drastically changed the treatment landscape of advanced ovarian tumors with BRCA mutations. However, the impact of this class of inhibitors in patients with advanced BRCA -mutant breast cancer is relatively modest. Using a syngeneic genetically-engineered mouse model of breast tumor driven by Brca1 deficiency, we show that tumor-associated macrophages (TAMs) blunt PARPi efficacy both in vivo and in vitro. Mechanistically, BRCA1-deficient breast tumor cells induce pro-tumor polarization of TAMs, which in turn suppress PARPi-elicited DNA damage in tumor cells, leading to reduced production of dsDNA fragments and synthetic lethality, hence impairing STING-dependent anti-tumor immunity. STING agonists reprogram M2-like pro-tumor macrophages into an M1-like anti-tumor state in a macrophage STING-dependent manner. Systemic administration of a STING agonist breaches multiple layers of tumor cell-mediated suppression of immune cells, and synergizes with PARPi to suppress tumor growth. The therapeutic benefits of this combination require host STING and are mediated by a type I IFN response and CD8 + T cells, but do not rely on tumor cell-intrinsic STING. Our data illustrate the importance of targeting innate immune suppression to facilitate PARPi-mediated engagement of anti-tumor immunity in breast cancer.
Fiber-integrated optical nano-tweezer based on a bowtie-aperture nano-antenna at the apex of a SNOM tip (2014)

We propose a new concept of fiber-integrated optical nano-tweezer on the basis of a single bowtie-aperture nano-antenna (BNA) fabricated at the apex of a metal-coated SNOM tip. We demonstrate 3D optical trapping of 0.5 micrometer latex beads with input power which does not exceed 1 mW. Optical forces induced by the BNA on tip are then analyzed numerically. They are found to be 10(3) times larger than the optical forces of a circular aperture of the same area. Such a fiber nanostructure provides a new path for manipulating nano-objects in a compact, flexible and versatile architecture and should thus open promising perspectives in physical, chemical and biomedical domains.
Ditopic Ion Transport Systems: Anion–π Interactions and Halogen Bonds at Work (2011)

Single-atom exchange series are introduced to extract the individual contributions of halogen bonds and anion–π interactions to the transport of anions across lipid bilayer membranes (see picture). Known cation binding sites are used for counterion activation of the neutral calix[4]arene transporters. The experimental evidence for anion transport with halogen bonds is unprecedented. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Disparate cardiovascular responses to passive tilt and mental stress in young and elderly normotensives (1991)

Moriguchi, Atsushi; Otsuka, Atsuhiro; Mikami, Hiroshi; Katahira, Katsutoshi; Tsunetoshi, Takeshi; Oishi, Mitsuru; Nagano, Noriko; Ogihara, Toshio Author Information
Analysis of Electrokinetic Data of Coal Slurry Oxidation by Parameter Estimation and Modeling Discrimination Techniques (2006)

Abstract not Available.
Interleukin-3 induces proliferation but not lymphokine activated killer activity from human and murine mononuclear cells. (1991)

Recombinant IL-3 (rIL-3) is a potent colony stimulating factor capable of stimulating early hematopoietic pluripotential progenitor cells and of supporting the differentiation of multiple cells. IL-3 has also been shown to have effects on mature, differentiated circulating cells including eosinophils and T cells. We evaluated the role of exogenous rIL-3 in the generation of cells with LAK activity from murine splenocytes and human bone marrow, spleen, unseparated PBMC and purified null cell preparations. rIL-3 was unable to generate lytic activity from any of these populations by itself and appeared to decrease LAK activity in bone marrow cultures containing high dose IL-2, (bone marrow derived cells (n = 3) with LAK activity for fresh tumor, mean lytic units(LU) 94.6 +/- 63.5 vs 32.8 +/- 44.8 for IL-2 and IL-2 plus IL-3 cultures, respectively p2 less than 0.05). Unlike previous reports testing murine cells, IL-3 priming and subsequent culture in IL-2 of human unseparated bone marrow cells or human or murine splenocytes, failed to generate long-term cultures with lytic activity. IL-3 did, however, induce a dose dependent stimulation of bone marrow and null cell preparations (mean null cell stimulation (3H Thymidine incorporation) with IL-3, 436 +/- 168 cpm vs 9802 +/- 9799 cpm, for 0 vs 10(3) units of IL-3, respectively n = 4, p2 less than 0.05). Furthermore, in bone marrow, unseparated PBMC and null cell cultures, the addition of rIL-3 generated characteristic large blastic appearing cells with prominent basophilic granules.(ABSTRACT TRUNCATED AT 250 WORDS)
An experimental investigation on viscoelastic behavior in tunable planar RF-MEMS resonators (2010)

In this paper, the viscoelastic behavior of a tunable RF-MEMS resonator and its impacts are studied by means of direct RF measurements for the first time. This tunable resonator consists of one λ/2 coplanar waveguide (CPW) resonator and two nanocrystalline-Ni RF-MEMS varactors. S-parameters of this tunable resonator have been measured for 80 hours under a bi-state bias condition of 0 and 40 V. It is demonstrated that the resonant frequency is shifted by 90 MHz and the varactor deformed by 0.12 μm over the 80 hour period. The gap of the loaded varactor is extracted from the measured S-parameters using finite-element analysis (FEA) tools. A generalized Voigt-Kelvin model is employed to verify the viscoelastic behavior of the resonator. The creep compliance extracted from the RF measurements is in excellent agreement with results in literature.
Fusion of real-time transrectal ultrasound with preacquired MRI for multimodality prostate imaging (2007)

A system for fusion of realtime transrectal ultrasound (TRUS) with pre-acquired 3D images of the prostate was designed and demonstrated in phantoms and volunteer patients. Biopsy guides for endocavity ultrasound transducers were equipped with customized 6 degree-of-freedom (DoF) electromagnetic (EM) tracking sensors, compatible with the Aurora EM tracking system (Northern Digital Inc, NDI, Waterloo, ON, Canada). The biopsy guides were attached to an ultrasound probe and calibrated to map tracking coordinates with ultrasound image coordinates. Six cylindrical gold seeds were placed in a prostate phantom to serve as fiducial markers. The fiducials were first identified manually in 3T magnetic resonance (MR) images collected with an endorectal coil. The phantom was then imaged with tracked realtime TRUS and the fiducial markers were identified in the live image using custom software. Rigid registrations between MR and ultrasound image space were computed and evaluated using subsets of the fiducial markers. Twelve patients were scanned with 3T MRI and TRUS for biopsy and seed placement. In ten patients, volumetric ultrasound images were reconstructed from 2D sweeps of the prostate and were manually registered with the MR. The rigid registrations were used to display live TRUS images fused with spatially corresponding realtime multiplanar reconstructions (MPRs) of the MR image volume. Registration accuracy was evaluated by segmenting the prostate in the MR and volumetric ultrasound and computing distance measures between the two segmentations. In the phantom experiments, registration accuracies of 2.2 to 2.3 mm were achieved. In the patient studies, the average root mean square distance between the MR and TRUS segmentations was 3.1 mm, the average Hausdorff distance was 9.8 mm. Deformation of the prostate during MR and TRUS scan was identified as the primary source of error. Realtime MR/TRUS image fusion is feasible and is a promising approach to improved target visualization during TRUS-guided biopsy or therapy procedures.
Biological evaluation of spiromesifen against Bemisia tabaci and an assessment of resistance risks (2003)

Guthrie F., Denholm A., Devine G.J., Nauen R., (2003), Biological Evaluation of spiromesifen against Bemisia tabaci and an assessment of resistance risks, Paper presented at the British Crop Production Council (BCPC) Conference, Glasgow, UK, 10-12 November, 2003, ISBN 1 901396 63 0, published by BCPC.
Strategies for Wheat Stripe Rust Pathogenicity Identified by Transcriptome Sequencing (2013)

Stripe rust caused by the fungus Puccinia striiformis f.sp. tritici (Pst) is a major constraint to wheat production worldwide. The molecular events that underlie Pst pathogenicity are largely unknown. Like all rusts, Pst creates a specialized cellular structure within host cells called the haustorium to obtain nutrients from wheat, and to secrete pathogenicity factors called effector proteins. We purified Pst haustoria and used next-generation sequencing platforms to assemble the haustorial transcriptome as well as the transcriptome of germinated spores. 12,282 transcripts were assembled from 454-pyrosequencing data and used as reference for digital gene expression analysis to compare the germinated uredinospores and haustoria transcriptomes based on Illumina RNAseq data. More than 400 genes encoding secreted proteins which constitute candidate effectors were identified from the haustorial transcriptome, with two thirds of these up-regulated in this tissue compared to germinated spores. RT-PCR analysis confirmed the expression patterns of 94 effector candidates. The analysis also revealed that spores rely mainly on stored energy reserves for growth and development, while haustoria take up host nutrients for massive energy production for biosynthetic pathways and the ultimate production of spores. Together, these studies substantially increase our knowledge of potential Pst effectors and provide new insights into the pathogenic strategies of this important organism.