gebhart/patrepeval huggingface dataset:
Multispectral Total-variation Reconstruction Applied to Lens-free Microscopy (2018)

Lens-free microscopy RGB-acquisitions are processed with an inverse problem approach: a multispectral total variation criterion is defined and minimized with the conjugate gradients method. Reconstruction results show the method is efficient to recover observed samples.
Reaction of lithium o-lithiophenoxide with carbonyl compounds (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of lithium o-lithiophenoxide with carbonyl compoundsJohn J. Talley and Irene A. EvansCite this: J. Org. Chem. 1984, 49, 26, 5267–5269Publication Date (Print):December 1, 1984Publication History Published online1 May 2002Published inissue 1 December 1984https://doi.org/10.1021/jo00200a056RIGHTS & PERMISSIONSArticle Views1468Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (477 KB) Get e-Alerts Get e-Alerts
Online geometric human interaction segmentation and recognition (2014)

We address the problem of online temporal segmentation and recognition of human interactions in video sequences. The complexity of the high-dimensional data variability representing interactions is handled by combining kernel methods with linear models, giving rise to kernel regression and kernel state space models. By exploiting the geometry of linear operators in Hilbert space, we show how the concept of parity space, defined for linear models, generalizes to the kernellized extensions. This provides a powerful and flexible framework for online temporal segmentation and recognition. We extensively evaluate the approach on a publicly available dataset, and on a new challenging human interactions dataset that we have collected. The results show that the approach holds the promise to become an effective building block for the analysis in real-time of human behavior.
Hydrodynamic interactions in metal rod-like particle suspensions due to induced charge electroosmosis (2008)

We present a theoretical and experimental study of the role of hydrodynamic interactions on the motion and dispersion of metal rod-like particles in the presence of an externally applied electric field. In these systems, the electric field polarizes the particles and induces an electroosmosis flow relative to the surface of each particle. The simulations include the effect of the gravitational body force, buoyancy, far-field hydrodynamic interactions, near-field lubrication forces, and electric field interactions. The particles in the simulations and experiments were observed to experience repeated pairing interactions in which they come together axially with their ends approaching each other, slide past one another until their centers approach, and then push apart. These interactions were confirmed in measurements of particle orientations and velocities, pair distribution functions, and net dispersion of the suspension. For large electric fields, the pair distribution functions show accumulation and depletion regions consistent with many pairing events. For particle concentrations of 1e8 particles/mL and higher, dispersion within the suspension dramatically increases with increased field strength.
Deposition: Hot Corrosion in Gas Turbine Engines (1981)

The superalloys employed in industrial marine and aircraft gas turbine engines are among the strongest and most oxidation resistant structural materials known. Moreover, it is common practice to further increase the surface stability of hot turbine components by the use of protective coatings. Nevertheless accelerated oxidation and corrosion occurs and can limit the use life of gas turbine components. The principal constituents of the deposits that accumulate on turbine components that are associated with accelerated corrosion are alkali salts. The source of the alkali constituents are generally believed to be sea salt crystals, which can travel hundreds of miles with the prevailing winds, or salt water contamination of otherwise clean fuels. The objective of the studies reported herein is to relate the modes of deposition of salts with corrosion and investigate the role of char as it affects corrosion so that the appropriate steps can be taken to increase gas turbine life.
Type I vs type II spiral ganglion neurons exhibit differential survival and neuritogenesis during cochlear development (2011)

Our study thus indicates that BDNF supply from the organ of Corti supports consolidation of type II innervation in the neonatal mouse cochlea. In contrast, type I SGNs likely rely on additional sources for trophic support.
Visual Observations of an Air-Water Mixture Flowing Through a Tube Support Plate With Circular-Hole and Trefoil-Hole Designs (1985)

The flow patterns of an air-water mixture at atmospheric pressure were visually observed through a simulated vertical steam generator tube support plate of circular hole and trefoil designs. Flow oscillations with a period on the order of 0.4 seconds were observed in both support plates at similar mass flow rate combinations. The oscillation consisted of a period of rapid surging followed by a low flow or stagnation period on the order of 0.1 seconds. Reverse (downward) flow was also observed for part of the oscillation cycle in the trefoil support plate. The flow oscillations that exist in one tube support plate are coupled to the oscillation phase that exists in the preceding tube support plate. The operation of a steam generator in a region where this flow oscillation occurs could result in reduced to steam generator life due to increased corrosion.
Guest Editor's Introduction Multiparadigm Languages and Environments (1986)

Presents the guest editorial for this issue of the publication.
Dynamical Study of Quasi-Steady Conditions for Startup Operations of Electrical Submersible Pumps (2017)

Abstract Electrical submersible pumps (ESPs) are subject to several failure modes that are well documented in the industry. Startup conditions have seen a lot of improvement over the past decade, with new generations of the variable speed drive (VSD) and controllers avoiding harmful frequencies to the system. Subsequently, ramping protocols are important to achieve safe and optimal pump operation. The present paper discusses the requirements to achieve a smooth and reliable startup of ESPs based on dynamical considerations. The analysis evaluates both mechanical and electrical constraints and their implications on a safe ramping procedure. It was found that a combination of different loads on the pump shaft can result in unwanted dynamical loads that could compromise the pump's operational reliability. It is shown that startup protocols close to the natural motor resistance are beneficial for a smooth and reliable rampup without compromising the system's stability.
B lymphocyte-specific protein binding near an immunoglobulin kappa-chain gene J segment. (1987)

Nuclear extracts from pre-B and B cell lines contain a nuclear DNA binding protein (kappa locus protein, KLP) that specifically recognizes a DNA sequence in the immunoglobulin kappa light chain joining (J) segment gene region. KLP is not observed in mature B cells, T cells, or nonlymphoid cell types. Two tandem binding sites for KLP designated KI and KII have been identified by methylation interference analysis to be immediately proximal to the J kappa 1 nonamer-heptamer recognition sequences and separated by 38 base pairs from each other. Fragments of DNA containing KI and KII sites compete for binding to KLP, and both protein-DNA complexes have the same electrophoretic mobility. Other flanking sequences of immunoglobulin gene fragments do not bind to KLP. The position of KLP-DNA binding and its tissue-specific expression suggest that it may be involved in the regulation of lymphoid gene DNA rearrangements by targeting recombinase to the kappa-chain gene region.
Involvement of CTGF in TGF-β1–Stimulation of Myofibroblast Differentiation and Collagen Matrix Contraction in the Presence of Mechanical Stress (2004)

In the presence of mechanical stress, CTGF is necessary for TGF-beta1-stimulation of myofibroblast differentiation and subsequent collagen matrix contraction, but CTGF alone is not sufficient to induce myofibroblast differentiation and collagen matrix contraction. Thus, TGF-beta1 appears to regulate multiple genes that are essential for fibroblast-mediated contraction of stressed matrix, one of which is CTGF.
Interface Properties between Lithium Metal and a Composite Polymer Electrolyte of PEO18Li(CF3SO2)2N-Tetraethylene Glycol Dimethyl Ether (2013)

The electrochemical properties of a composite solid polymer electrolyte, consisting of poly(ethylene oxide) (PEO)-lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) and tetraethylene glycol dimethyl ether (TEGDME) was examined as a protective layer between lithium metal and a water-stable lithium ion-conducting glass ceramic of Li1+x+y(Ti,Ge)2-xAlxP3-ySiyO12 (LTAP). The lithium ion conductivity and salt diffusion coefficient of PEO18LiTFSI were dramatically enhanced by the addition of TEGDME. The water-stable lithium electrode with PEO18LiTFSI-2TEGDME, as the protective layer, exhibited a low and stable electrode resistance of 85 Ω·cm2 at 60 °C, after 28 days, and low overpotentials of 0.3 V for lithium plating and 0.4 V for lithium stripping at 4.0 mA·cm-2 and 60 °C. A Li/PEO18LiTFSI-2TEGDME/LTAP/saturated LiCl aqueous solution/Pt, air cell showed excellent cyclability up to 100 cycles at 2.0 mAh·cm-2.
EXPOSURE OPTIONS FOR THE REVISION KNEE: GETTING THERE SAFELY (2014)

Obtaining adequate exposure is key to optimising outcomes in revision total knee arthroplasty. Goals of the exposure include protecting the extensor mechanism, safe removal of the components that are in place and implantation of the revision components. Challenges to these goals include prior skin incisions, arthrofibrosis, and patella baja. Choosing a skin incision is the first important step. The blood supply to the skin is predominantly derived MEDIALLY and thus the most LATERAL skin incision that works for obtaining exposure is selected. If skin flaps are required, they MUST be full thickness as the blood supply to the skin runs deep just over the fascial layer and partial thickness flaps risk skin necrosis. Avoid acute angles between old skin incisions of The work-horse of revision TKA is the medial parapatellar approach. It includes a generous medial release that allows the surgeon to externally rotate and deliver the tibia by pivoting on the extensor mechanism. An anterior synovectomy is then performed to re-establish the medial and lateral gutters followed by re-establishment of the space behind the patellar tendon to free it from the proximal tibia and finally subluxation of the patella (preferable to formal eversion). A lateral release (or peel of the soft tissue off of the lateral side of the patella) is a final step to mobilise the extensor mechanism (if required). After the components are removed, a posterior capsulectomy is performed followed by re-establishment of the flexion space behind the femur further enhances tibial exposure for both bony preparation and revision component implantation. If the above maneuvers are performed, and exposure is still inadequate, the easiest way to improve exposure is by performing a quadriceps snip. This is an oblique, apical extension of the arthrotomy ACROSS THE PATELLAR TENDON (NOT in the muscle; it is hard to repair if performed in the muscle). It is repaired side to side with no need to alter post-operative physical therapy and heals reliably. The V-Y Quadricepsplasty is a proximal release of the extensor mechanism; essentially perform by connecting the apical extension of the medial parapatellar arthrotomy with a lateral release across the quadriceps tendon. It is classically indicated for patients with extensor mechanism contracture where the surgeon wishes to lengthen it. It usually results in increased flexion at the expense of an extensor lag and is used rarely in contemporary practice. Tibial Tubercle Osteotomy is a distal release of the extensor mechanism that is most useful for accessing the canal to remove long-stemmed cemented tibial components. It is a coronal osteotomy made from the medial side of the tubercle that is usually made 5–8 cm in length, tapering from approximately 1cm thick proximally to 5mm distally.
Identification of GBF1 as a Cellular Factor Required for Hepatitis C Virus RNA Replication (2009)

In infected cells, hepatitis C virus (HCV) induces the formation of membrane alterations referred to as membranous webs, which are sites of RNA replication. In addition, HCV RNA replication also occurs in smaller membrane structures that are associated with the endoplasmic reticulum. However, cellular mechanisms involved in the formation of HCV replication complexes remain largely unknown. Here, we used brefeldin A (BFA) to investigate cellular mechanisms involved in HCV infection. BFA acts on cell membranes by interfering with the activation of several members of the family of ADP-ribosylation factors (ARF), which can lead to a wide range of inhibitory actions on membrane-associated mechanisms of the secretory and endocytic pathways. Our data show that HCV RNA replication is highly sensitive to BFA. Individual knockdown of the cellular targets of BFA using RNA interference and the use of a specific pharmacological inhibitor identified GBF1, a guanine nucleotide exchange factor for small GTPases of the ARF family, as a host factor critically involved in HCV replication. Furthermore, overexpression of a BFA-resistant GBF1 mutant rescued HCV replication in BFA-treated cells, indicating that GBF1 is the BFA-sensitive factor required for HCV replication. Finally, immunofluorescence and electron microscopy analyses indicated that BFA does not block the formation of membranous web-like structures induced by expression of HCV proteins in a nonreplicative context, suggesting that GBF1 is probably involved not in the formation of HCV replication complexes but, rather, in their activity. Altogether, our results highlight a functional connection between the early secretory pathway and HCV RNA replication.
A Single-Step Bottom-up Approach for Synthesis of Highly Uniform Mie-Resonant Crystalline Semiconductor Particles at Visible Wavelengths (2023)

Optically Mie-resonant crystalline silicon nanoparticles have long attracted interest for their unique scattering behaviors. Here, we report a bottom-up nonthermal plasma process that produces highly monodisperse particles, with diameters controllable between 60 and 214 nm, by temporarily electrostatically trapping nanoparticles inside a continuous-flow plasma reactor. The particle size is tuned by adjusting the gas residence time in the reactor. By dispersing the nanoparticles in water, optical extinction measurements indicate colloidal solutions of a particle-based metafluid in which particles support both strong magnetic and electric dipole resonances at visible wavelengths. The spectral overlap of the electric and magnetic resonances gives rise to directional Kerker scattering. The extinction measurements show excellent agreement with Mie theory, supporting the idea that the fabrication process enables particles with narrow distributions in size, shape, and composition. This single-step gas-phase process can also produce Mie-resonant nanoparticles of dielectric materials other than silicon and directly deposit them on the desired substrates.
Abstract A32: Identification and characterization of colon cancer-associated antigens (2010)

Abstract Colon cancer (CRC) is an immunogenic tumor and adaptive immunity may play a role in inhibiting disease relapse. A vaccine to boost cellular immunity in CRC patients could prevent disease recurrence, but there have been few defined immunogenic proteins identified as vaccine candidates. TVG has shown that overexpressed tumor associated proteins, abundant in the cancer state but expressed at basal levels in normal cells, can be immunogenic. We hypothesized that ideal candidate antigens would be ones already validated as prognostic markers in multivariate analysis. We performed a directed literature review using search words e.g. colon cancer, prognosis, biomarker, multivariate analysis. We selected a panel of eight proteins based on (1) incidence of expression, (2) independent predictor of poor prognosis, (3) independent predictor of early disease recurrence, and (4) known biologic function in CRC pathogenesis. Using a web based algorithm program developed by TVG, we identified peptides that were predicted to be high affinity binders across multiple HLA DR alleles; characteristics we have shown to be associated with native epitopes of self tumor antigens. We selected and synthesized 19 peptides predicted to be the highest binders. We evaluated the potential immunogenicity of peptides with 1. IFN-g ELISPOT assays using PBMC from CRC patients and normal controls and 2. specific IgG antibody response with ELISA using sera from CRC patients and normal controls. We quantitated antigen gene expression using qPCR in cell lines representing microsatellite unstable (MSI), chromosome unstable (CIN) and CpG island methylator phenotype (CIMP) colorectal cancer. The eight proteins are: CDC25B, COX-2, EBAG9, EGFR, Fascin-1, IGF-1R, PRL-3 and VCP. Two of the eight proteins had already been shown to be human tumor antigens. For all candidate antigens there was a greater IFN-g response in CRC patients than in controls; for three proteins, this difference reached statistical significance. Six proteins were positive by ELISA. Seven antigen genes were overexpressed relative to normal colon. We conclude that: 1. biologically relevant CRC associated proteins can be identified that are associated with prognosis, 2. epitopes predicted to bind multiple DR alleles, derived from candidate antigens, elicit T cell responses greater in CRC patients than in normal controls, 3. there was an overexpression of candidate genes across three different CRC phenotypes, and 4. these antigens may represent novel immunologic targets for CRC. Citation Information: Cancer Prev Res 2010;3(12 Suppl):A32.
Furoxan derivatives demonstrated in vivo efficacy by reducing Mycobacterium tuberculosis to undetectable levels in a mouse model of infection (2020)

Altogether, we have identified two advanced lead compounds, (14b) and (14c), as novel promising candidates for the treatment of TB infection.
Best-First Surface Realization (1996)

Current work in surface realization concentrates on the use of general, abstract algorithms that interpret large, reversible grammars. Only little attention has been paid so far to the many small and simple applications that require coverage of a small sublanguage at different degrees of sophistication. The system TG/2 described in this paper can be smoothly integrated with deep generation processes, it integrates canned text, templates, and context-free rules into a single formalism, it allows for both textual and tabular output, and it can be parameterized according to linguistic preferences. These features are based on suitably restricted production system techniques and on a generic backtracking regime.
Upstream Elements Involved in Vivo in Activation of the Brain-specific Rat Aldolase C Gene (1998)

The rat aldolase C gene encodes a glycolytic enzyme strongly expressed in adult brain. We previously reported that a 115-base pair (bp) promoter fragment was able to ensure the brain-specific expression of the chloramphenicol acetyltransferase (CAT) reporter gene in transgenic mice, but only at a low level (Thomas, M., Makeh, I., Briand, P., Kahn, A., and Skala, H. (1993) Eur. J. Biochem. 218, 143-151). Here we show that in vivo activation of this promoter at a high level requires cooperation between an upstream 0.6-kilobase pair (kb) fragment and far upstream sequences. In the 0.6-kb region, a 28-bp DNA element is shown to include overlapping in vitro binding sites for POU domain regulatory proteins and for the Winged Helix hepatocyte nuclear factor-3beta factor. An hepatocyte nuclear factor-3beta-binding site previously described in the short proximal promoter fragment is also shown to interact in vitro with POU proteins, although with a lower affinity than the 28-bp motif. Additional binding sites for POU factors were detected in the upstream 0.6-kb sequences. Progressive deletion in this region resulted in decreased expression levels of the transgenes in mice, suggesting synergistic interactions between these multiple POU-binding sites. We propose that DNA elements characterized by a dual binding specificity for both POU domain and Winged Helix transcription factors could play an essential role in the brain-specific expression of the aldolase C gene and other neuronal genes.
Modelli deformabili della mano a partire da dati acquisiti tramite laser scanner (2011)

Questa tesina mostra come sia possibile realizzare il modello tridimensionale di una mano reale utilizzando uno scanner 3D economico. Lo scopo di questo lavoro e di creare un database contenente le mani di differenti persone a cui e associato uno scheletro. Attraverso l’uso di software specializzato e stato creato uno scheletro per ogni modello. Tali modelli verranno poi utilizzati per lo sviluppo di una tecnica di riconoscimento della mano da una camera 3D. Sono stati realizzati dei video-tutorial reperibili online che descrivono i procedimenti seguiti
In-Wall Network (Mesh) Cooling Augmentation of Gas Turbine Airfoils (2004)

The present study investigates a new class of in-wall mesh cooling techniques intended to produce significant wetted surface area heat transfer enhancement products, hAAwetted, with low to moderate pressure losses. Cooling networks (meshes) are presented using round pins and rounded diamond shaped pins with H/Dp ratios of 0.2 and S/Dp ratios of 1.5, as well as less dense rounded diamond pins of smaller diameter with H/Dp of 0.3 and S/Dp of 2.14. These geometries differ substantially from conventional pin fin arrays in which H/Dp ≥ 1 and S/Dp ratios are typically about 2.5. The objective of mesh cooling is to provide highly effective cooling inside component walls while maintaining very thin outer protective skin thickness. Special attention is paid to the combination of techniques including pin meshes, turbulators, and concavity arrays that can provide multiple design solutions for heat transfer and pressure loss goals. Average channel wetted-area heat transfer capabilities exceeding 3 times that of smooth channels have been demonstrated using actual surface area enhancements of no more than 20%. This cooling capability increase is also realized with a large decrease in channel material solidity, up to 30%, compared to conventional pin fin arrays. Friction factor enhancements in the range of 15 to 25 times that of a smooth channel turbulent flow accompany this performance. This investigation represents the first of its kind to demonstrate feasible in-wall cooling methods that may be realized in practice for investment cast turbine blades.