gebhart/patrepeval huggingface dataset:
Connected OFCity: Technology Innovations for a Smart City Project (2017)

Around the world, municipalities have been making substantial investments into broadband access infrastructure to accelerate the build-out of an urban phenomenon that has become known as a smart or connected city. At the 2016 Optical Fiber Communications Conference, a team contest, the Connected OFCity Challenge, was held to discuss the technological innovations and to examine dependencies and intricacies of a connected city project. The participants, four teams of experts coming from a cross-section of the industry, presented and defended their visions of future applications and innovative architecture and technologies to realize the interconnection. This paper provides a synthesis of the four competitive proposals offered for the contest and their ensuing discussions.
Partial pressure of arterial carbon dioxide after resuscitation from cardiac arrest and neurological outcome: A prospective multi-center protocol-directed cohort study (2018)

Abstract Aims Partial pressure of arterial carbon dioxide (PaCO2) is a regulator of cerebral blood flow after brain injury. We sought to test the association between PaCO2 after resuscitation from cardiac arrest and neurological outcome. Methods A prospective protocol-directed cohort study across six hospitals. Inclusion criteria: age ≥18, non-traumatic cardiac arrest, mechanically ventilated after return of spontaneous circulation (ROSC), and receipt of targeted temperature management. Per protocol, PaCO2 was measured by arterial blood gas analyses at one and six hours after ROSC. We determined the mean PaCO2 over this initial six hours after ROSC. The primary outcome was good neurological function at hospital discharge, defined a priori as a modified Rankin Scale ≤3. Multivariable Poisson regression analysis was used to test the association between PaCO2 and neurological outcome. Results Of the 280 patients included, the median (interquartile range) PaCO2 was 44 (37–52) mmHg and 30% had good neurological function. We found mean PaCO2 had a quadratic (inverted “U” shaped) association with good neurological outcome, with a mean PaCO2 of 68 mmHg having the highest predictive probability of good neurological outcome, and worse neurological outcome at higher and lower PaCO2. Presence of metabolic acidosis attenuated the association between PaCO2 and good neurological outcome, with a PaCO2 of 51 mmHg having the highest predictive probability of good neurological outcome among patients with metabolic acidosis. Conclusion PaCO2 has a “U” shaped association with neurological outcome, with mild to moderate hypercapnia having the highest probability of good neurological outcome.
Controlling the surface chemistry and chromatographic properties of methacrylate‐ester‐based monolithic capillary columns via photografting (2007)

Preparation of monolithic capillary columns for separations in the CEC mode using UV-initiated polymerization of the plain monolith followed by functionalization of its pore surface by photografting has been studied. The first step enabled the preparation of generic poly(butyl methacrylate-co-ethylene dimethacrylate) monoliths with optimized porous properties, controlled by the percentages of porogens 1-decanol and cyclohexanol in the polymerization mixture, irradiation time, and UV light intensity. Ionizable monomers [2-(methacryloyloxy)ethyl]trimethylammonium chloride or 2-acryloamido-2-methyl-1-propanesulfonic acid were then photografted onto the monolithic matrix, allowing us to control the direction of the EOF in CEC. Different strategies were applied to control the grafting density and, thereby, the magnitude of the EOF. To control the hydrophobic properties, two approaches were tested: (i) cografting of a mixture of the ionizable and hydrophobic monomers and (ii) sequential grafting of the ionizable and hydrophobic monomers. Cografting resulted in similar retention but higher EOF. With sequential grafting, more than 50% increase in retention factors was obtained and a slight decrease in EOF was observed due to shielding of the ionizable moieties.
Demonstration of “Automatic” Turbulence Mitigation of 4 QPSK Channels in a Self-Coherent Free-Space Mode-Division-Multiplexed Link Using a Pilot Beam and Photodetector Array (2023)

We experimentally demonstrate “automatic” turbulence mitigation of a self-coherent FSO MDM link with four 1-Gbaud QPSK channels using a transmitted pilot beam and PD array without power-splitting losses or detector-bandwidth sharing. Results show &lt;3-dB turbulence-induced penalty, as compared to a &gt;16-dB penalty for a conventional LO-based MDM system.
Evaluating Barriers and Tools to Optimize Resident Call Scheduling on Neurology In-Patient Services (P8-7.006) (2023)

<h3>Objective:</h3> A quality improvement project to identify the challenges in call scheduling and validating a custom digital tool to optimize call schedule generation. <h3>Background:</h3> Overnight call coverage in academic centers is a fundamental component of healthcare and education. Schedules are often made manually and need to take into account many complex factors. This potentially detracts from education, patient care and resident well-being. <h3>Design/Methods:</h3> This quality improvement study aims to reduce the time to produce an accurate call schedule by 40% in 12 months at an adult neurology residency program. Secondary measures include reduction of revisions by 50% and subjective difficulty by 30% on a 10 point Likert Scale. Alongside a senior software engineer, the author has developed a custom program (“CRONUS”) that utilizes constraint algorithms to instantaneously apply desired features. Plan-Do-Study-Act (PDSA) cycles will apply additional features as directed by feedback every four weeks to determine the factors that optimize call schedule production. <h3>Results:</h3> Initial surveys described difficulties with visualization and desire for automation to provide a preliminary schedule. Across five hospitals, a mean of 4.6 hours was required to complete a schedule with 3.1 revisions and a difficulty rating of 5.9 (out of 10). Thus far, preliminary data using “CRONUS” has shown a 25% reduction in total number of hours required, 33% reduction in average revisions required and 27% reduction in subjective difficulty. Additional data are being collected and will be presented at the time of the conference. <h3>Conclusions:</h3> There is a significant reduction in overall time required, number of revisions and perceived difficulty when using the program. Additional PDSA cycles will be required to confirm its efficacy, identify additional factors and implement new features to optimize them. Future directions include use in other residency programs as well as application to clinical informatics to optimize outpatient clinic scheduling. <b>Disclosure:</b> Dr. Im has nothing to disclose. Dr. Kassardjian has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi Genzyme. Dr. Kassardjian has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion. Dr. Kassardjian has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Alexion. Dr. Khosravani has nothing to disclose. Dr. Mitchell has nothing to disclose.
Pressure induced modification of a cemented carbide (2001)

WC/Co cemented carbide is a composite material for highly demanding wear applications. The unique combination of hardness (from the WC-phase) and toughness (from the binder Co) gives a material especially suitable for rock drilling. This thesis, investigates the deterioration and wear of these cemented carbide buttons and the correlation to different rock types.To better understand the nature of the wear of the cemented carbide buttons, the counter surface –the rock- has also been studied. A range of important rock types has been investigated with respect to hardness distribution and scratch response in a micro scale and friction properties when slid against cemented carbides. The cemented carbide may deteriorate due to a number of mechanisms. The effect of fatigue in the structure was studied in TEM and particle erosion response was used to probe the corresponding mechanical degradation. Further, homing cross sectioning has been developed and used as a new technique to investigate the presence of weak zones in the surface layer of a drill button. It was found that rock penetration into this layer is a very common mechanism, with profound implications for the nature of the wear. High resolution scanning electron microscopy has been extensively used to map the deterioration and wear of numerous drill buttons, worn against different rock types in different kinds of drilling applications. Finally, the collected data on the surface damage, the reptile skin formation, the rock intrusion and the properties of the rock are assembled into a new view of the deterioration and wear of cemented carbide in rock drilling.
GC-GAP, a Rho Family GTPase-activating Protein That Interacts with Signaling Adapters Gab1 and Gab2 (2003)

Gab1 and Gab2 are scaffolding proteins acting downstream of cell surface receptors and interact with a variety of cytoplasmic signaling proteins such as Grb2, Shp-2, phosphatidylinositol 3-kinase, Shc, and Crk. To identify new binding partners for GAB proteins and better understand their functions, we performed a yeast two-hybrid screening with hGab2-(120-587) as bait. This work led to identification of a novel GTPase-activating protein (GAP) for Rho family GTPases. The GAP domain shows high similarity to the recently cloned CdGAP and displays activity toward RhoA, Rac1, and Cdc42 in vitro. The protein was named GC-GAP for its ability to interact with GAB proteins and its activity toward Rac and Cdc42. GC-GAP is predominantly expressed in the brain with low levels detected in other tissues. Antibodies directed against GC-GAP recognized a protein of approximately 200 kDa. Expression of GC-GAP in 293T cells led to a reduction in active Rac1 and Cdc42 levels but not RhoA. Suppression of GC-GAP expression by siRNA inhibited proliferation of C6 astroglioma cells. In addition, GC-GAP contains several classic proline-rich motifs, and it interacts with the first SH3 domain of Crk and full-length Nck in vitro. We propose that Gab1 and Gab2 in cooperation with other adapter molecules might regulate the cellular localization of GC-GAP under specific stimuli, acting to regulate precisely Rac and Cdc42 activities. Given that GC-GAP is specifically expressed in the nervous system and that it is localized to the dendritic processes of cultured neurons, GC-GAP may play a role in dendritic morphogenesis and also possibly in neural/glial cell proliferation.
Inverse halftonning using sparse coding methods (2016)

We propose a new inverse halftonning algorithm based on sparse coding approach, which is able to simultaneously reconstruct the continuous-tone image from the halftonned one and increase spatial image resolution. To achieve this goal, we introduce the halftonning operator that maps the continuous-tone signal into the same representation as the halftonned one. Resolution enhancement is obtained with a pair of the linked dictionaries which consist of low resolution and high resolution patches. Comparison with some famous algorithms has demonstrated that our algorithm outperformed them by both image quality and applicability to different halftone types.
DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions (2017)

Age-associated clonal hematopoiesis caused by acquired mutations in myeloid cancer-associated genes is highly prevalent in the normal population. Its etiology, biological impact on hematopoiesis, and oncogenic risk is poorly defined at this time. To gain insight into this phenomenon, we analyzed a cohort of 2530 related and unrelated hematologically normal individuals (ages 55 to 101 years). We used a sensitive gene-targeted deep sequencing approach to gain precision on the exact prevalence of driver mutations and the proportions of affected genes. Mutational status was correlated with biological parameters. We report a higher overall prevalence of driver mutations (13.7%), which occurred mostly (93%) in <i>DNMT3A</i> or <i>TET2</i> and were highly age-correlated. Mutation in these 2 genes had some distinctive effects on end points. <i>TET2</i> mutations were more age-dependent, associated with a modest neutropenic effect (9%, <i>P</i> = .012), demonstrated familial aggregation, and associated with chronic obstructive pulmonary disease. Mutations in <i>DNMT3A</i> had no impact on blood counts or indices. Mutational burden of both genes correlated with X-inactivation skewing but no significant association with age-adjusted telomere length reduction was documented. The discordance between the high prevalence of mutations in these 2 genes and their limited biological impact raise the question of the potential role of dysregulated epigenetic modifiers in normal aging hematopoiesis, which may include support to failing hematopoiesis.
ChemInform Abstract: Effect of Na2O Additions in the Crystallization of Barium Ferrite from a BaO‐B2O3‐Fe2O3 Glass. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High Definition Geomagnetic Models: A New Perspective for Improved Wellbore Positioning (2012)

Abstract Earth’s gravity and magnetic fields are used as natural reference frames in directional drilling. The azimuth of the bottomhole assembly is inferred by comparing the magnetic field measured-while-drilling (MWD) with a geomagnetic reference model. To provide a reference of sufficient quality for accurate well placement, the US National Geophysical Data Center (NGDC), in partnership with industry, has developed high-definition geomagnetic models (HDGM), updated regularly using the latest satellite, airborne and marine measurements of the Earth’s magnetic field. Standard geomagnetic reference models represent the main magnetic field originating in the Earth’s liquid core, but the new models additionally account for crustal magnetic anomalies, which constitute a significant source of error in directional drilling. NGDC maintains a public archive of global ship and airborne magnetic field measurements. These are compiled into a global magnetic anomaly grid and expanded into ellipsoidal harmonics. The harmonic expansion coefficients are then included in the high-definition models to accurately represent the direction and strength of the local geomagnetic field. The latest global model to degree and order 720 resolves magnetic anomalies down to 28 km half-wavelength, achieving more than an order-of-magnitude improvement over previous models. A side-by-side comparison of different on- and off-shore regions shows the high level of local detail represented in the new model. Accounting for a larger waveband of the geomagnetic spectrum significantly improves the accuracy of the reference field. This directly benefits the reliability of the well azimuth determination. We further demonstrate that model accuracy is a prerequisite for applying drill string interference corrections. Finally, an accurate reference model facilitates the validation of MWD surveys by keeping the field acceptance criteria centered on the true downhole magnetic field. Together, these factors improve well placement, prevent and mitigate the danger of collision with existing wellbores and enable real-time steering to save rig-time and reduce drilling costs.
Abstract 1803: Lethal synthesis: Potent anticancer activity of a glycine uptake inhibitor in tumor cells with mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) knocked down (2022)

Abstract Methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) is a mitochondrial bifunctional enzyme with dehydrogenase and cyclohydrolase activity. MTHFD2 is expressed in embryonic tissues and not in adult tissues, and by generating formate for purine biosynthesis, enhances proliferation. It is over expressed in many cancers, including breast cancer, and has become an important cancer drug target. Knockdown (KD) of MTHFD2 in breast cancer cell lines MCF7 and T47D, slowed proliferation and resulted in an increase in early apoptosis and a S-phase block. Lack of MTHFD2 causes a dependence on glycine, and in the absence of glycine, proliferation of the MCF-7 cell line with MTHFD2 knocked down was inhibited even further. A known specific glycine transporter type-I (GlyT1) inhibitor, ORG 25935 potently inhibited growth of MCF7 cell with MTHFD2 KD, while it had less of an effect on T47D cells with MTHFD2 KD. Furthermore, both cell lines with MTHFD2 KD showed increase in expression of GlyT1 (SLC6A9) at both mRNA and protein level, using the qPCR and western blotting, respectively. The metabolomics studies showed that intracellular glycine, and NAD+ pools are more reduced in control cells compared to MTHFD2 KD cells on treatment with GlyT1 inhibitor, suggesting that this inhibitor causes glycine depletion in the cells. These data encourage the development of inhibitors of MTHFD2 for use in combination with glycine transport inhibitors. Citation Format: Gulam Mohmad Rather, Joseph R. Bertino. Lethal synthesis: Potent anticancer activity of a glycine uptake inhibitor in tumor cells with mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) knocked down [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1803.
Raman spectroscopy of the high Tc superconductor yttrium barium copper oxide (YBa2Cu3O7) and the semiconductor yttrium barium copper oxide (YBa2Cu3O6) (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRaman spectroscopy of the high Tc superconductor yttrium barium copper oxide (YBa2Cu3O7) and the semiconductor yttrium barium copper oxide (YBa2Cu3O6)Yuanfang Dai, J. S. Swinnea, H. Steinfink, J. B. Goodenough, and Alan CampionCite this: J. Am. Chem. Soc. 1987, 109, 17, 5291–5292Publication Date (Print):August 1, 1987Publication History Published online1 May 2002Published inissue 1 August 1987https://pubs.acs.org/doi/10.1021/ja00251a051https://doi.org/10.1021/ja00251a051research-articleACS PublicationsRequest reuse permissionsArticle Views253Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Designing a Metasurface-based Tag Antenna for Wearable Vital Sign Sensors (2019)

This paper aims to design a tag antenna with metasurfaces for use in a wearable vital-sign sensing system. The system is based on a bistatic self-injection-locked (SIL) radar that consists of a chest-worn SIL oscillator (SILO) tag and a wireless handheld receiver. A frequency selective surface (FSS) and an electromagnetic bandgap (EBG) surface are placed on the front and back side of the tag antenna to reduce the influence of moving clutter and body proximity, respectively, on the system. In the experiment, a 5.8 GHz prototype system was implemented with the proposed tag antenna to monitor vital signs of a wearer who was walking in place.
Monitoring Fluidization Dynamics for Detection of Changes in Fluidized Bed Composition and Operating Conditions (1998)

Abstract In many industrial applications of gas-solids fluidized beds, the hydrodynamics of the bed can change over time, either by imposed alterations (e.g., a grade change) or by unwanted phenomena (e.g., agglomeration). In both cases, it is worthwhile to have an on-line monitoring method for detecting these changes quickly. In this paper, such a method, based on the short-term predictability of fluidized bed pressure fluctuations, is examined. Its sensitivity has been investigated by experiments with small step changes in the superficial gas velocity and by experiments with a gradual change in the particle size distribution of the solids in the bed. For both types of experiments, it is shown that the monitoring method detects changes in the excess gas velocity as small as 0.01 m/s. Furthermore, it is demonstrated that the method is well able to indicate if a stationary hydrodynamic state has been reached after a change in the particle size distribution (a ‘grade change’).
Highly available process support systems: implementing backup mechanisms (2003)

Availability in process support systems (PSS) can be achieved by using standby mechanisms that allow a backup server to take over in case a primary server fails. These mechanisms, resembling the process pair approach used in operating systems, require the primary to send information about state changes to the backup on a regular basis. In PSS where all relevant state information is stored in a database, there are two principal strategies for synchronizing a primary-backup pair. One is to use the replication mechanisms provided by the DBMS. Another is to implement a message mechanism to exchange state information between servers above the database level. For both approaches, several variants exist that allow to trade run-time performance for failover time. This paper discusses the possible strategies and evaluates their performance based on an implementation within the OPERA process support kernel.
Visual prognosis and vitreous cytokine levels after arteriovenous sheathotomy in branch retinal vein occlusion associated with macular oedema (2007)

Both improvement in BCVA and decrease in FT were observed after PPV in BRVO patients with macular oedema. Interestingly, these visual prognoses strongly correlate with the vitreous level of IL-6, whereas the duration of BRVO strongly correlates with the vitreous level of VEGF.