gebhart/patrepeval huggingface dataset:
Kriging-guided Level Set Method for Structural Topology Optimization (2017)

Crashworthiness optimization problems are characterized by strong nonlinearities and discontinuities. Hence, gradient-based methods cannot be used and alternative approaches have to be considered. Here, a novel, kriging-based method for level set topology optimization is proposed and validated on a crash test case. Compared to CMA-ES, this method demonstrates to be eﬃcient in terms of convergence speed and promising in the context of crash topology optimization.
Yersinia pseudotuberculosis mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1 (2010)

Manganese has an important yet undefined role in the virulence of many bacterial pathogens. In this study we confirm that a null mutation in Yersinia pseudotuberculosis mntH reduces intracellular manganese accumulation. An mntH mutant was susceptible to killing by reactive oxygen species when grown under manganese-limited conditions. The mntH mutant was defective in survival and growth in macrophages expressing functional Nramp1, but in macrophages deficient in Nramp the bacteria were able to survive and replicate. In Galleria mellonella, the mntH mutant was attenuated. Taken together, these data suggest a role for manganese in Y. pseudotuberculosis during macrophage intracellular survival, protecting the bacteria from the antimicrobial products released during the respiratory burst.
Action of propanil on in vivo chlorophyll a fluorescence in Echinochloa crus‐galli and rice (1981)

Summary: When sprayed as a post‐emergent, foliar herbicide propanil destroyed Echinochloa crus‐galli (L.) with little or no visible injury to rice, confirming its selective contact action. In treated rice leaves there was, however, a temporary decrease in dry weight, pigments, proteins and photosynthetic products followed by complete recovery in 4–5 days. In both rice and E. crus‐galli , at lower concentrations propanil inhibited the electron flow in a manner similar to that of DCMU, but at higher concentrations it damaged the primary electron donor. In vivo chlorophyll a fluorescence kinetics determined at various times after spraying 1% propanil in the field confirmed progressive weed deterioration. Rice leaves showed a decreased fluorescence for a few hours but exhibited partial recovery from the effects of propanil within 6 h and total recovery within 48 h after spraying. When the leaves were infiltrated with propanil solutions there was good recovery of fluorescence in both weed and crop leaves at 0.01% while at 1% both were drastically affected. With 0.1% propanil, fluorescence in the weed leaves deteriorated progressively while the crop leaves recovered after 4 h of incubation. This suggests that the crop has also an effective endogenous detoxifying mechanism.
(Invited) Advanced Materials for Integrated on-Chip Power Converter (2015)

We describe electrolessly plated magnetic material s required for the demonstration of a monolithically integrated on-chip inductors. Miniaturization of magnetic inductors and integration on semiconductor chips requires the choice of high performance magnetic materials. The requirements are soft magnetic properties with low coercive force (Hc &lt; 1.0) and high saturation magnetization, high resistivity (r &gt;=110 mohm cm) to reduce inductor losses at high frequencies from eddy currents, and excellent thermal stability to a processing temperature that is dictated by the integration process on-chip (&gt;200~250 o C). This work demonstrates that a Co 85 W 5 P 10 thin film deposited using electroless chemistry on a Pd activated Ni 80 Fe 20 seed layer meets all the materials requirements for a low process temperature integrated inductor. A 1.2 mm thick CoWP layer deposited on a 60nm Ni 80 Fe 20 seed layer has a resistivity of 110 mohm cm and its moment and anisotropy are stable after 200 o C thermal cycling. The work also shows that the initial stages of growth, starting from the magnetic Ni 80 Fe 20 seed layer surface, affect greatly the growth and thermal stability of the CoWP film. As far as maintaining a higher ~250°C thermal processing limit, we obtained encouraging data for CoWP and NiFeBP films thinner than 300nm grown by electroless deposition. We will also discuss approaches to achieving laminated films incorporating these materials.
High single-mode-yield 1.3-μm gain-coupled DFB lasers with truncated QWs: comprehensive comparison between theory and experiment (2002)

In conclusion, we believe we have made a first systematic comparison between theory and experiment for 1.3-/spl mu/m truncated gain coupled (GC) DFB lasers. Experimental correlation among laser properties is compared, which agrees well with theoretical predictions under the influence of random laser facet phases. This type of laser has the potential to be used for high-speed, coolerless, array, and integration applications.
Supplementary Table 3 from Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study (2023)

&lt;p&gt;Global and promoter CpG island demethylation in available paired pre- and post-treatment (8 weeks) hormone-resistant and triple-negative tumor biopsies.&lt;/p&gt;
Current handling capability of the neutral point of a three-phase/switch/level boost-type PWM (VIENNA) rectifier (2002)

In this paper the stationary operational behavior of a three-phase/switch/level PWM rectifier is analyzed for asymmetrical loading of the output partial voltages. For the considerations a sinusoidal mains current shape, resistive behavior of the mains current fundamental and constant pulse frequency are assumed. Based on analytical calculations it is shown that the average value of the neutral point current (which has to be formed for asymmetrical load) has an approximately linear dependency on the distribution of the overall relative on-time of the switching states of the system being redundant concerning the voltage formation between begin and end of a pulse half interval. The maximum admissible load of the neutral point (capacitive output voltage center point) is calculated. This load is given as a function of the amplitude of the mains current and the voltage transfer ratio of the system. The calculations are checked by results of a digital simulation of the system behavior. Furthermore, the increase of the rms value of the ripple of the mains current of the rectifier is analyzed as it results in forming of an average value of the neutral point current. As a basis for comparison, the ripple rms value is used which results in harmonic-(sub)optimal control and negligible average value of the neutral point current. Finally, the current stress on the power semiconductors and on the output capacitors of the system are compiled in the form of diagrams which can be applied directly for dimensioning the system.
The PRONTO amyloidosis study: A randomized, double-blind, placebo-controlled, global, phase 2b study of NEOD001 in previously treated subjects with light chain amyloidosis and persistent cardiac dysfunction. (2016)

TPS8073 Background: In light chain (AL) amyloidosis, the accumulation of misfolded light chain (LC) protein may lead to organ failure and death. Patients are treated primarily with plasma cell–targeting agents that reduce LC production. Organ function can improve over time but is often incomplete. There is a substantial need for therapies that treat organ dysfunction. NEOD001, a monoclonal antibody that targets misfolded LC, is hypothesized to neutralize circulating soluble LC and to clear insoluble deposits from organs. In an ongoing phase 1/2 study (NCT02613182; Gertz M et al, J Clin Oncol, 2016) in 27 patients with AL amyloidosis and persistent organ dysfunction, monthly NEOD001 infusions were well tolerated and produced no infusion-related hypersensitivity reactions. In a best response analysis of subjects who fulfilled eligibility criteria at baseline, 57% met cardiac and 60% met renal response criteria. The current study (PRONTO; NCT02632786) is a randomized, double-blind, placebo-controlled, phase 2b trial of NEOD001 in patients with AL amyloidosis who responded to previous systemic therapy but have persistent cardiac dysfunction. Methods: Eligible patients (estimated enrollment, 100) with AL amyloidosis, ≥ 1 previous systemic treatment ( > 6 months earlier with partial hematologic response [HR] or better), and cardiac dysfunction (N-terminal pro-brain natriuretic peptide [NT-proBNP] 650-5000 pg/mL; clinical heart failure signs; left ventricular wall thickness > 12 mm, or cardiac biopsy–detected amyloidosis) will be randomly assigned (1:1) to receive NEOD001 (24 mg/kg q28d) or placebo and will be stratified according to NT-proBNP ( < 1800 vs ≥ 1800 pg/mL) and HR to initial plasma cell therapy (complete/very good partial vs partial response). The primary end point is cardiac best response (NT-proBNP; baseline to month 12). Key secondary end points include change in Short Form-36 Questionnaire response, 6-minute walk test distance, Neuropathy Impairment Score–Lower Limb, progression free-survival, renal best response (defined by Palladini G et al, Blood 2014), and safety. Clinical trial information: NCT02632786.
ChemInform Abstract: The INOC Approach to the Hydroazulenone Ring System. A Potential Entry to the Guaianolides and Pseudoguaianolides. (1983)

Abstract Das aus Cyclopentadien ( I) erhaltene Malonsäureesterderivat (II) wird weiter zu der Nitroverbindung (III) kondensiert, die mit Phenylisocyanat über eine Nitriloxid‐Bildung zu (IV) cyclisiert wird.
Wavelength tunable characteristics of mid-infrared intracavity 3-&#x00B5;m waveband light source with 805-nm-band laser diode excitation (2010)

A wavelength tunable mid-infrared 3-μm waveband light source with an effective intracavity system is successfully demonstrated using a high-performance 805-nm-band laser diode excitation. Advantages include wide-tunability (approx. 90-nm), simple wavelength controllability, and a small footprint.
Joint Reconstruction and Calibration Using Regularization by Denoising with Application to Computed Tomography (2021)

Regularization by denoising (RED) is a broadly applicable framework for solving inverse problems by using priors specified as denoisers. While RED has been shown to provide state-of-the-art performance in a number of imaging applications, existing RED algorithms require exact knowledge of the measurement operator characterizing the imaging system, limiting their applicability in problems where the measurement operator has parametric uncertainties. We propose a new method, called Calibrated RED (Cal-RED), that enables joint calibration of the measurement operator along with reconstruction of the unknown image. Cal-RED extends the traditional RED methodology to imaging problems that require the calibration of the measurement operator. We validate Cal-RED on the problem of image reconstruction in computerized tomography (CT) under perturbed projection angles. Our results corroborate the effectiveness of Cal-RED for joint calibration and reconstruction using pre-trained deep denoisers as image priors.
Systolic blood pressure estimation using ECG and PPG in patients undergoing surgery (2022)

In a significant portion of surgeries, blood pressure (BP) is often measured non-invasively in an intermittent manner. This practice has a risk of missing clinically relevant BP changes between two adjacent intermittent BP measurements. This study proposes a method to non-invasively estimate systolic blood pressure (SBP) with high accuracy in patients undergoing surgery. Continuous arterial BP, electrocardiography (ECG), and photoplethysmography (PPG) signals were acquired from 29 patients undergoing surgery. After extracting 9 features from the PPG and ECG signals, we dynamically selected features upon each intermittent measurement (every 10 min) of SBP based on feature robustness and the principle of correlation-based feature selection. Finally, multiple linear regression models were built to combine these features to estimate SBP every 30 s. Compared to the reference SBP, the proposed method achieved a mean of difference at 0.08 mmHg, a standard deviation of difference at 7.97 mmHg, and a correlation coefficient at 0.89 (p < 0.001). This study demonstrates the feasibility of non-invasively estimating SBP every 30 s with high accuracy during surgery by using ECG, PPG, and intermittent SBP measurements every 10 min, which meets the standard of the Association for the Advancement of Medical Instrumentation. The proposed method has the potential to enhance BP monitoring in the operating room, improving patient outcomes and experiences.
Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01 (2019)

Potent and broadly neutralizing antibodies (bnAbs) are the hallmark of HIV-1 protection by vaccination. The membrane-proximal external region (MPER) of the HIV-1 gp41 fusion protein is targeted by the most broadly reactive HIV-1 neutralizing antibodies. Here, we examine the structural and molecular mechansims of neutralization by anti-MPER bnAb, LN01, which was isolated from lymph-node-derived germinal center B cells of an elite controller and exhibits broad neutralization breadth. LN01 engages both MPER and the transmembrane (TM) region, which together form a continuous helix in complex with LN01. The tilted TM orientation allows LN01 to interact simultaneously with the peptidic component of the MPER epitope and membrane via two specific lipid binding sites of the antibody paratope. Although LN01 carries a high load of somatic mutations, most key residues interacting with the MPER epitope and lipids are germline encoded, lending support for the LN01 epitope as a candidate for lineage-based vaccine development.
Disparity-Aware Stereo 3D Production Tools. (2011)

Stereoscopic 3D (S3D) has reached wide levels of adoption in consumer and professional markets. However, production of high quality S3D content is still a difficult and expensive art. Various S3D production tools and systems have been released recently to assist high quality content creation. This paper presents a number of such algorithms, tools and systems developed at Disney Research Zurich, which all make use of disparity-aware processing.
Effector-dependent activation and oligomerization of NRC helper NLRs by Rpi-amr3 and Rpi-amr1 (2022)

Abstract Plant pathogens compromise crop yields. Plants have evolved robust innate immunity that depends in part on intracellular Nucleotide-binding, Leucine Rich-Repeat (NLR) immune receptors that activate defense responses upon detection of pathogen-derived effectors. Most “sensor” NLRs that detect effectors require the activity of “helper” NLRs, but how helper NLRs support sensor NLR function is poorly understood. Many Solanaceae NLRs require the NRC (NLR-Required for Cell death) class of helper NLRs. We show here that Rpi-amr3, a sensor NLR from Solanum americanum , detects AVRamr3 from the potato late blight pathogen, Phytophthora infestans , and activates oligomerization of the helper NLR NRC2 into a high-molecular weight resistosome. The NRC2 resistosome also forms upon recognition of P. infestans effector AVRamr1 by another sensor NLR, Rpi-amr1. The ATP-binding motif of Rpi-amr3 is required for NRC2 resistosome formation, but not for interaction with the cognate effector. The NRC2 resistosome can be activated by AVRamr3 homologs from other Phytophthora species. Mechanistic understanding of NRC resistosome formation will underpin engineering crops with durable disease resistance.
Polymer Elasticity-Driven Wrinkling and Coarsening in High Temperature Buckling of Metal-Capped Polymer Thin Films (2004)

We report the critical effects the deformational stress from the elastic nature of a confined polymer layer has during the relaxation process on the buckling of thin metal-polymer bilayer systems (less than 100 nm) even above the temperature at which the polymer is in the liquid flow region. In contrast with what is generally believed, the dispersion force does not play a significant role in the buckling. We also find that the final wrinkled waves take on the shape of wormlike islands. The coarsening leading to the island structure is driven by the growth in amplitude of the dominant wave at the expense of less dominant ones.
The Relative Pathogenicity of Candida Krusei and C. Albicans in the Rat Oral Mucosa (1998)

The relative pathogenicity of Candida krusei and C. albicans was investigated by assessing their colonisation and infectivity of the Sprague-Dawley rat oral mucosa. During an initial 21-week period with intermittent oral inoculation, both Candida spp. demonstrated variable surface colonisation of the oral mucosa. After 3 days of oral inoculation, both yeast species were recovered from all animals. During the 21-week period the mean oral load of C. albicans in the control group of rats varied between (26-274) x 10(1) cfu/ml whereas the two test groups of rats carrying C. krusei CK9 and CK13 had a mean load of (2-10) x 10(1) cfu/ml. Although oral colonisation by C. albicans was greater than that of C. krusei, neither species induced candidal infection during this period. Subsequent immunosuppression of the rats by intramuscular cyclophosphamide (40 mg/kg body weight) initiated C. albicans infection of the dorsal tongue (around the conical papillae area) after 4 weeks, in all of three animals while similar lesions due to C. krusei were seen--albeit after 5-7 weeks--in three of eight animals. Characteristic histological changes of mucosal candidosis were discernible on the lingual mucosa of rats infected with both Candida spp. including parakeratosis, absence of a stratum granulosum, thickened rete ridges, micro-abscess formation and polymorph infiltration of the lingual epithelium. Although both species produced fungal hyphae that penetrated the epithelium up to the prickle cell layer, C. albicans hyphae tended to be relatively more profuse. Taken together these results substantiate, for the first time in an animal model, the clinical evidence that C. krusei, once considered an innocuous commensal, is capable of transforming into an invasive pathogen under conditions of immunosuppression.
QoS-aware multicast for internet video applications (2007)

In this paper we extend our work in joint design of source rate control and congestion control for unicast video streaming, and propose a cross-layer design approach for Internet video multicast applications. By jointly designing source rate control at application layer and multicast congestion control at transport layer, our QoS-aware multicast approach can provide better QoS support for multimedia applications and significantly improve the playback quality, while maintaining good long-term TCP friendliness.
Supplementary Table 1 from Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules (2023)

Supplementary Table 1 from Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules
Ov‐ASP‐1, the Onchocerca volvulus homologue of the activation associated secreted protein family is immunostimulatory and can induce protective anti‐larval immunity (2004)

Vaccination of mice with a recombinant protein, Ov-ASP-1, the Onchocerca volvulus homologue of the activation associated secreted gene family stimulated very high titres of both IgG1 and IgG2a without adjuvant. rOv-ASP-1 was also immuno-reactive with IgG isotypes from both O. volvulus-infected (INF) and putatively immune (PI) humans, with higher IgG4 in the former group. The protein also stimulated IFN-gamma secretion by PBMC from INF and PI and IL-5 only in INF. Using a mouse diffusion chamber model, vaccination with rOv-ASP-1 resulted in partial but significant protection against challenge with infective third-stage larvae (L3) but only when formulated with Freund's complete adjuvant (FCA) or alum. Protection was Th1-dependent (highly elevated IgG2a) with FCA and contingent on a strongly Th2-skewed (IgG1) response with alum. IgE responses to rOv-ASP-1 with or without adjuvant were weak or absent. When immunization using rOv-ASP-1 in adjuvant failed to induce adequate Th1 (FCA) or Th2 (alum) responses, protection efficacy was compromised. The recombinant protein appears to stimulate a mixed Th1/Th2 response but the outcome in terms of protective immunity is the result of a subtle interplay of its intrinsic and adjuvant-augmented properties. Ov-ASP-1 is potentially secreted based on its localization in the secretory granules of L3.
Assay of Florfenicol in Swine Feed: Interlaboratory Study (2009)

Nuflor (florfenicol) Premix for Swine was recently approved by the U.S. Food and Drug Administration (FDA) for control of swine respiratory disease (SRD). A simple method for the assay of florfenicol in Type C medicated swine feeds was recently evaluated as part of a 4-laboratory study. Florfenicol is extracted from ground feed with acetonitrile-water by shaking and sonication. An Envi-Carb solid-phase extraction cartridge is used to clean up the extract, retaining matrix interferences while allowing florfenicol to elute. The collected eluent is diluted and injected into a reversed-phase liquid chromatographic system. Samples are quantitated by external standard analysis versus multilevel calibration solutions. The procedure is suitable for the quantification of swine feeds in mash or pellet form medicated with 100-300 mg/kg florfenicol. The interlaboratory study was conducted according to Guidance 136 issued by the FDA Center for Veterinary Medicine. The feeds used to evaluate method performance represented different feed compositions (starter and finisher) and manufacturers. The sponsor and 3 independent laboratories obtained mean recoveries (+/-SD) from fortified swine feeds of 100.7% (+/-2.0%), 99.6% (+/-2.8%), 98.8% (+/-1.4%), and 99.3% (+/-1.7%), respectively. Excellent agreement of the results of the assay of blind samples of commercial swine mash and pelleted feeds between laboratories demonstrates that the method is rugged and reproducible.
High-speed SAR prediction for mass production stages in a factory by H-field measurements [cellular radio applications] (2004)

The purpose of this study is to develop a new system with which SAR measurements can be made in a shorter period of time, suitable for mass production stages. Our major concern is to evaluate the specific absorption rate (SAR) from the viewpoint of quality control in a factory, but not the compliance testing or regulation. For factory use, we have developed a new measurement system that makes use of a noble algorithm that predicts the SAR from the measurement of the magnetic field distribution in the vicinity of a cellular radio in free space. The developed system can predict the SAR in as little as 30 seconds, and is thus particularly suitable for the production stage in a factory for quality control purposes.