gebhart/patrepeval huggingface dataset:
A Method for Wafer-Scale Encapsulation of Large Lateral Deflection MEMS Devices (2009)

Packaging of microelectromechanical systems (MEMS) is a critical step in the transition from development to commercialized product. This paper presents a thin-film encapsulation process that allows varying trench widths suitable for MEMS devices with lateral deflections as large as 20 ¿m. The process involves the deposition and planarization of a sacrificial-oxide layer of up to 23 ¿m thick, the deposition of a 20 ¿m epitaxial-silicon sealing cap, the release of structures using hydrofluoric acid (HF) vapor, and the sealing of the structure at low pressure. Devices produced using this encapsulation method are capable of surviving standard backend processes such as wafer singulation and wire bonding. Among the numerous types of devices encapsulated, two different types of silicon MEMS resonators were fabricated. These functioning resonators demonstrate the ability of the process to successfully encapsulate devices, taking advantage of both large and small trench widths. Such a generalized fabrication platform greatly expands the possibilities of the wafer-scale encapsulation to numerous MEMS devices and retains the robustness necessary for backend processing.
K-NN search using local learning based on regression for image prediction with neighbor embedding (2013)

International audience
Fibrin Scaffold as a Carrier for Mesenchymal Stem Cells and Growth Factors in Shoulder Rotator Cuff Repair (2016)

With an increase in the aging population, rotator cuff tears are becoming more common. High failure rates with shoulder rotator cuff repair surgery have been persistent, prompting the introduction of biologic methods to promote healing. The aim of the present technique is to deliver stem cells and growth factors to the footprint of the repair site. A platelet-rich plasma (PRP) fibrin clot is used as a scaffold for the delivery of stem cells, by using PRP, to provide a source of growth factors, and platelet-poor plasma (PPP) as a source for fibrinogen for the matrix for the scaffold. In the second step, bone marrow is harvested from the proximal humerus, concentrated, and combined with the PRP and PPP. Using a customized device, we then activate the clotting process and transfer the scaffold containing the stem cells using a suture anchor onto the shoulder rotator cuff footprint. In an effort to promote healing, this technique reimplants autologous stem cells and growth factors into the operative site. This technique may serve as an alternative for typically used scaffolds such as collagen matrices or decellularized human dermis patches.
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys (2013)

(Article begins on next page) The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters.
Cerebral MR angiography with multiple overlapping thin slab acquisition. Part II. Early clinical experience. (1992)

In a prospective, multicenter study of 164 patients, cerebral magnetic resonance (MR) angiography with multiple overlapping thin slab acquisition was evaluated for image quality and diagnostic accuracy. Of the 164 patients, 87 (53%) underwent either correlative cut-film angiography or surgery. The overall image quality was excellent in 90% of patient studies. Eighteen of 19 aneurysms were detected with MR angiography. The parent artery, the anatomy of the neck and dome, and the size were correctly shown in 17 of the 19 aneurysms. All 19 vascular malformations were seen with MR angiography. Venous malformations and single pedicle arteriovenous malformations were completely defined with MR angiography, while complete definition of complex arteriovenous malformations was frequently difficult. In cerebral tumors, the arteries and veins important in surgical planning were accurately shown in all cases. In ischemic cerebrovascular disease, MR angiography depicted all stenoses and occlusions of first- and second-order cerebral arteries. The inability to depict intraluminal filling defects in any but the large central arteries limited the ability of MR angiography to enable the specific diagnosis of embolic stroke.
Concentric Nebulizer (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Mechanical Response of Organic and Mineral Raman Shifts in Cortical Bone and Ageing Effects (2017)

In recent years, bone diseases such as osteoporosis, which tend to cause fractures due to a decrease in bone strength accompanying aging, are becoming a problem. Evaluating bone microscopic mechanical properties and evaluating bone strength is an important research leading to the treatment of bone diseases. Using the component analysis method called Raman spectroscopy, the change in Raman shift was measured while applying load to bone tissue, and the relationship between stress and Raman shift was investigated. In addition, the Raman shifts were measured by statistical process based on the Raman images. The specimens with the sizes of 10 × 2 × 0.5 mm were cut out from bovine femoral diaphysis (Age: 1 m.o., 23 m.o. and 7 y.o.), where the longer edges of specimens are aligned to the parallel to the femoral axis. Strain gauges were attached to bovine cortical bone specimens, and Raman spectrum was measured while applying tensile stress. The Raman shifts were calculated by averaging obtained peak shifts at all measurements point. As the results, a negative correlation was found between tensile load and Raman shift in ν2PO34－ , ν4PO34－ and ν1PO34－. In addition, at 23 months of age, there was a tendency of the increase of changes in Raman shifts.
212 IN VIVO STRAIN GAUGE ATTACHMENT TO MOUSE FEMORA. (2006)

Manuscript Submission Guidelines: Journal if Investigative Medicine (JIM) This Journal recommends that authors follow the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals formulated by the International Committee of Medical Journal Editors (ICMJE). Please read the guidelines below and then visit the Journal’s submission
DeepFly3D, a deep learning-based approach for 3D limb and appendage tracking in tethered, adult Drosophila (2019)

Studying how neural circuits orchestrate limbed behaviors requires the precise measurement of the positions of each appendage in three-dimensional (3D) space. Deep neural networks can estimate two-dimensional (2D) pose in freely behaving and tethered animals. However, the unique challenges associated with transforming these 2D measurements into reliable and precise 3D poses have not been addressed for small animals including the fly, <i>Drosophila melanogaster</i>. Here, we present DeepFly3D, a software that infers the 3D pose of tethered, adult <i>Drosophila</i> using multiple camera images. DeepFly3D does not require manual calibration, uses pictorial structures to automatically detect and correct pose estimation errors, and uses active learning to iteratively improve performance. We demonstrate more accurate unsupervised behavioral embedding using 3D joint angles rather than commonly used 2D pose data. Thus, DeepFly3D enables the automated acquisition of <i>Drosophila</i> behavioral measurements at an unprecedented level of detail for a variety of biological applications.
Efficient Importance Sampling Techniques for the Photon Map (2000)

TLR2 and TLR4 interaction and a specific VDR haplotype influence protection against PTB in Moroccans patients.
MicroRNA alteration and putative target genes in high‐grade prostatic intraepithelial neoplasia and prostate cancer: STAT3 and ZEB1 are upregulated during prostate carcinogenesis (2016)

STAT3 and ZEB1 could be the key molecules altered at the early stages of carcinogenesis, especially in HGPIN. Prostate 76:937-947, 2016. © 2016 Wiley Periodicals, Inc.
Leith-Upatnieks holography in computational sensors (2006)

Holographic optical elements are a critically enabling component of modern spectroscopy and spectral imaging systems. While the most common holographic elements are essentially those discovered in 1962 by Leith and Upatnieks, several decades passed prior to the effective integration of holography and sensing. Over 5 decades Emmett Leith was a prime mover in both the birth and the maturation of computational holographic sensors. Recent demonstrations of the unique utility of holographic filtering suggest that continued improvements in materials and recording processes for Leith's original concept will yield tremendous results. This paper describes the <i>multiple order coded aperture</i> (MOCA) spectrometer as an example of the potential for advanced holography in computational sensors.
COMPACT, TUNABLE COMPTON SCATTERING GAMMA-RAY SOURCES (2009)

Recent progress in accelerator physics and laser technology have enabled the development of a new class of gamma-ray light sources based on Compton scattering between a high-brightness, relativistic electron beam and a high intensity laser pulse produced via chirped-pulse amplification (CPA). A precision, tunable gamma-ray source driven by a compact, high-gradient X-band linac is currently under development at LLNL. High-brightness, relativistic electron bunches produced by the linac interact with a Joule-class, 10 ps laser pulse to generate tunable {gamma}-rays in the 0.5-2.5 MeV photon energy range via Compton scattering. The source will be used to excite nuclear resonance fluorescence lines in various isotopes; applications include homeland security, stockpile science and surveillance, nuclear fuel assay, and waste imaging and assay. The source design, key parameters, and current status are presented.
USING POLARIMETRIC IMAGING AND SPECTROSCOPY OF THE CORONA FROM 400 TO 1800 NM FOR EXPLORING THE NEAR SUN PLASMA (2006)

Total solar eclipses offer unique opportunities for exploring the solar corona, in par- ticular for validating new concepts, and testing new instrumentation. The scientific goals of the experiments, planned for the total solar eclipse of 29 March 2006, at Waw AnNamous, Libya, by the eclipse group from the Institute for Astronomy (IfA) at the University of Hawaii, were as fol- lows: (1) to search for the signature of silicon nanometer size dust grains in the corona, (2) to search for the signature of a neutral wind of interstellar origin in the corona, (3) to understand the nature of near-Sun dust from F-coronal visible and IR spectra, and (4) to establish the direction of the coronal magnetic field from its origin at the Sun as it expands into interplanetary space. A complement of imaging and spectroscopic polarization measurements, covering the wavelength range from 400 to 1800 nm, were designed and constructed to achieve these objectives. The observ- ing conditions during the total solar eclipse deemed ideal, and the experiments were successfully executed to achieve these milestones.
System Data Management: An Inter-Disciplinary Collaboration Architecture for Systems Engineering (2005)

This paper presents a novel approach to integrating systems engineering (SE) artifacts and methods with discipline-specific detailed design artifacts and processes, for the purpose of facilitating inter-disciplinary collaboration. In particular, it addresses the lifecycle management of complex products involving mechanical, electrical, electronics and software aspects, and being designed following a formal product development methodology. The primary motivation of the approach is to capture and maintain the traceability between the concrete artifacts stored in discipline-specific “repositories” and the abstract artifacts used to support system-level decisions as well as system integration. The proposed approach acknowledges the fundamental differences that exist between the various engineering disciplines and therefore favors a loose coupling based on a process-centric management of the artifacts traceability links. These considerations lead to an inter-disciplinary collaboration and infrastructure pattern called “system data management” (SDM), with the role of enforcing the integrity of the inter-disciplinary traceability between artifacts. As a byproduct, this approach suggests a novel perspective on product data management (PDM) and software configuration management (SCM) integration that sharply contrasts with point-to-point integration solutions. The authors have implemented a prototype based on a service-oriented architecture (SOA) and existing PDM and SCM technologies.
ChemInform Abstract: Unique Chemistry at Ice Surfaces: Incomplete Proton Transfer in the H3O+—NH3 System. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Prognostic and predictive value of circulating DNA for hepatic arterial infusion of chemotherapy for patients with colorectal cancer liver metastases (2020)

Hepatic arterial infusion (HAI) of chemotherapy is an experimental treatment option for patients with colorectal cancer liver metastases (CRCLM). The current study aimed to investigate the predictive and prognostic value of cell free DNA (cfDNA) in patients with CRCLM receiving HAI with oxaliplatin and systemic capecitabine. Plasma samples from 62 patients were investigated who were included into a single arm phase II study investigating HAI treatment for patients with CRCLM. The clinical outcome of the trial has been presented previously. In brief, treatment consisted of intrahepatic infusion of oxaliplatin 100 mg/m<sup>2</sup> every second week with concomitant oral capecitabine 3,500 mg/m<sup>2</sup> every second week for up to 12 cycles. Blood samples were drawn at baseline and follow-up and plasma was analyzed for cell free DNA using a direct fluorescent assay. The baseline level of plasma cfDNA was 0.92 ng/µl (95% CI 0.84-1.00). Patients with a baseline value of cfDNA above the 75th quartile had a median overall survival of 2.4 years (95% CI 0.7-2.8), compared with 3.9 years (95% CI 2.8-5.9) for patients below the 75th quartile (P=0.02). The baseline level of cfDNA was significantly lower (0.91 ng/µl, 95% CI 0.76-0.98) in patients who achieved an objective response compared to non-responders (1.79 ng/µl; 95% CI 0.99-2.57; P=0.02). The current study demonstrated a possible prognostic and predictive value of cfDNA for patients with CRCLM undergoing HAI with oxaliplatin and concomitant capecitabine.
Fast algorithm for the modulated complex lapped transform (2003)

A new algorithm for fast computation of the modulated complex lapped transform (MCLT) is presented. For a length-M MCLT, the algorithm is based on computing a length-2M fast Fourier transform plus M butterfly-like stages, without data shuffling. That reduces the number of operations and memory accesses needed to compute the MCLT when compared to previous algorithms. Compared to the original type-4 discrete-cosine-transform-based algorithm, an implementation of the new algorithm leads to 25% faster execution.
Structuring a Product Design Process for Optimizing the Scale of Derivative Development (2020)

In derivative development, by planning a reasonable design process in advance, the development scale can be suppressed. However, no systematic method to structure a process is established. This research proposes a method to structure a process so that the scale can be optimized. For this purpose, a hypothesis about the rationale of senior designers is made and implemented as a mathematical model on a computer to help designers structure a process. A process is described as sequences between tasks that are defined as functional measures and design parameters to achieve them, which are depicted in domain mapping matrix. Pareto optimal processes in three metrics depicting the rationale are suggested. The designer examines the contents of the processes among different scales and determines an appropriate process and thus the appropriate scale. Case studies on a continuously variable transmission confirm the effectiveness of the proposed method.
Feasibility study of robot enhanced mobility in children with cerebral palsy (2012)

Mobility is a causal factor in infant development. Neural impaired Infants, e.g., born with cerebral palsy (CP), have motor disability and are at risk for further developmental delays due to lack of self-generated mobility. It is possible that these impaired infants may benefit from robot enhanced mobility where they learn to drive a robot via a joystick, i.e., the mobility comes from the robot but the infants control the motion via a joystick. It is our hypothesis that such an enriched mobility experience will minimize delays in attaining other social and developmental childhood milestones. However, presently, there are no reported studies if children with CP would learn to drive a robot using a joystick and if they will sustain interest in doing so over multiple days of training. Also, it remains to be seen if such a robot enhanced mobility will impact development scores in this group of children. In this feasibility study, we use a special purpose robotic chair driven by a joystick to encourage infants and toddlers to drive. The study involved 20 children with CP in progressively difficult driving tasks over 10 sessions of training 20 minutes each. We found that after multiple training sessions, all children advanced in their driving skills and benefited in GMFM-88 functional scores.
High speed resonant cavity enhanced Ge photodetectors on Si reflecting substrates for 1550 nm operation (2005)

We have fabricated high-speed resonant-cavity-enhanced Ge-on-SOI photodetectors, operating at 1550 nm and demonstrating a 3 dB bandwidth of 12.8 GHz. When optimized, these high-speed detectors should exhibit a quantum efficiency of 75% at 1550 nm.
Prospects for Vaccines to Protect Against AIDS, Tuberculosis, and Malaria (2001)

Given the scope of the worldwide health problems caused by the acquired immunodeficiency syndrome, tuberculosis, and malaria, it is imperative that vaccines be developed to prevent these infections. Recent advances in the understanding of these diseases suggest that T-lymphocyte-mediated immunity is important in containing these infections. The application of novel vaccine technologies for eliciting this type of immunity promises to provide successful vaccines for controlling the spread of these deadly infections.
On the micro-architectural impact of clock distribution using multiple PLLs (2002)

Clock distribution has traditionally been a circuit design problem with negligible micro-architectural impact. However, for clock distribution networks using multiple phase-locked loops (PLLs), this will most likely not be the case. This paper discusses the micro-architectural impact of using multiple PLLs for clock distribution. Two PLL phase synchronization algorithms are presented and analyzed. They are compared in terms of efficiency, performance, and complexity. For both, the micro-architectural impact is small, but certainly not negligible.
Enantioselective Synthesis of Cyclic Sulfamidates (2010)

Cyclic sulfamidates are important precursors for the synthesis of 1,2-functionalized amine building blocks like 1,2-amino alcohols and α-amino acids. Herein, a rapid and mild procedure towards enantiomerically pure sulfamidates 2 starting from cyclic sulfamidate imines 1, using a rhodium-catalyzed asymmetric transfer hydrogenation is described. This protocol opens a route to these building blocks with very high yields and nearly perfect enantioselectivities. Moreover, the methodology was used in a short synthesis of the mexiletine analogue 7, which is an effective sodium channel blocker.
Transmutable Nanoparticles with Reconfigurable Surface Ligands* (2020)

Unlike conventional inorganic materials, biological systems are exquisitely adapted to respond to their surroundings. Proteins and other biological molecules can process a complex set of chemical binding events as informational inputs and respond 1106accordingly via a change in structure and function. We applied this principle to the design and synthesis of inorganic materials by preparing nanoparticles with reconfigurable surface ligands, where interparticle bonding can be programmed in response to specific chemical cues in a dynamic manner. As a result, a nascent set of “transmutable nanoparticles” can be driven to crystallize along multiple thermodynamic trajectories, resulting in rational control over the phase and time evolution of nanoparticle-based matter.
ITSY Handheld Software Radio (2001)

Abstract : Software radio technology promises to eliminate existing radio interoperability problems, provide a path for rapidly incorporating advances in digital communications, and enable new applications and waveforms that take advantage of the tremendous flexibility. However, the current state of low power processing technology limits application to low power handheld radios. A handheld software radio platform would enable the construction of devices that could inter-operate with multiple legacy systems, download new waveforms and be used to construct adhoc networks that optimize the physical layer for the current conditions. Low power operation is the most significant challenge facing software radio. While some approaches sacrifice considerable flexibility by using technologies such as re-configurable logic, we believe that the advances in processor power management will make a pure software radio approach feasible in a handset in 3-5 years. A prototype handheld software radio based on the 200 MHz StrongARM processor was designed and fabricated under this contract, and several representative waveforms were ported to the platform. This work enabled us to evaluate the capabilities handheld software radio based on existing processor technology, and provides benchmarks that can be used to assess the capabilities of software radio systems based on future lowpower processors.