gebhart/patrepeval huggingface dataset:
Hyaluronic acid–doxorubicin nanoparticles for targeted treatment of colorectal cancer (2020)

Colorectal cancer, common in both men and women, occurs when tumors form in the linings of the colon. Common treatments of colorectal cancer include surgery, chemotherapy, and radiation therapy; however, many colorectal cancer treatments often damage healthy tissues and cells, inducing severe side effects. Conventional chemotherapeutic agents such as doxorubicin (Dox) can be potentially used for the treatment of colorectal cancer; however, they suffer from limited targeting and lack of selectivity. Here, we report that doxorubicin complexed to hyaluronic acid (HA) (HA-Dox) exhibits an unusual behavior of high accumulation in the intestines for at least 24 hr when injected intravenously. Intravenous administrations of HA-Dox effectively preserved the mucosal epithelial intestinal integrity in a chemical induced colon cancer model in mice. Moreover, treatment with HA-Dox decreased the expression of intestinal apoptotic and inflammatory markers. The results suggest that HA-Dox could effectively inhibit the development of colorectal cancer in a safe manner, which potentially be used a promising therapeutic option.
Imaging performance of CMOS and a-Si:H flat-panel detectors for C-arm fluoroscopy and cone-beam CT (2018)

<strong>Purpose: </strong>CMOS detectors are a potentially advantageous sensor technology for indirect-detection flat-panel detectors (FPDs), offering finer pixel pitch, faster frame rate, and lower electronic noise compared to a-Si:H sensors. This work presents a preliminary analysis of the 2D and 3D imaging performance of both detector technologies. <strong>Methods:</strong> Two mobile C-arms were equipped with CMOS (Xineos 3030HS) and a-Si:H (PaxScan 3030X) FPDs. Technical assessment includes measurement of spatial resolution (MTF), image noise (NPS), and detective quantum efficiency (DQE). Evaluation of CBCT performance considers soft tissue visibility including axial image MTF, NPS, and noise-equivalent quanta (NEQ). <strong>Results:</strong> The CMOS detector exhibited lower readout noise and slightly higher spatial resolution as expected. The a- Si:H detector showed about 10-15% higher DQE at low spatial frequencies while the CMOS detector showed greater resilience in DQE at higher spatial frequencies. In matched resolution CBCT, both detectors showed roughly equivalent performance. <strong>Conclusion:</strong> CMOS detectors benefit performance with respect to high-frequency tasks, but the current work did not demonstrate strong advantage with respect to low-contrast soft-tissue visualization, in part due to light losses in scintillator-semiconductor coupling. Additional advantages include improved frame rate (reduced CBCT scan time). Ongoing work includes further investigation of modified bandwidth filters to take better advantage of underlying noiseresolution properties.
Non-interactive zero-knowledge and its applications (1988)

We show that interaction in any zero-knowledge proof can be replaced by sharing a common, short, random string. We use this result to construct the first public-key cryptosystem secure against chosen ciphertext attack.
The Noncoronary Cusp as a Site for Successful Ablation of Accessory Pathways: Electrogram Characteristics in Three Cases (2010)

Radiofrequency ablation is the treatment of choice to cure symptomatic patients with atrioventricular accessory pathways (APs). Septal APs are challenging because of the proximity of the normal conduction system. In some patients, despite aggressive lesion creation on the right anteroseptal region pathway, ablation is unsuccessful. We report 3 cases where the successful ablation site was in the noncoronary cusp of the aortic valve and discuss possible defining features of this variant of septal APs and an approach for successful ablation.
Photoemission from single-crystalline Bi-Sr-Ca-Cu-O (1988)

An x-ray photoemission experiment was performed on high-${T}_{c}$ superconducting Bi-Sr-Ca-Cu-O single crystals with ${T}_{c}\ensuremath{\sim}80$ K. It is found that Sr and Ca are interchangeable on the lattice sites of the crystal and that they are electronically distinguishable. This is consistent with the structure model for the crystal with formula unit ${\mathrm{Bi}}_{2}{(\mathrm{S}\mathrm{r},\mathrm{C}\mathrm{a})}_{3}{\mathrm{Cu}}_{2}{\mathrm{O}}_{y}$. We demonstrate how the distribution of Sr and Ca in the cation sites is determined by x-ray photoemission, which cannot be done by x-ray diffraction.
In situ Raman spectroscopy for growth monitoring of vertically aligned multiwall carbon nanotubes in plasma reactor (2014)

Portable and highly sensitive Raman setup was associated with a plasma-enhanced chemical vapor deposition reactor enabling in situ growth monitoring of multi-wall carbon nanotubes despite the combination of huge working distance, high growth speed and process temperature and reactive plasma condition. Near Edge X-ray absorption fine structure spectroscopy was used for ex situ sample analysis as a complementary method to in situ Raman spectroscopy. The results confirmed the fact that the “alternating” method developed here can accurately be used for in situ Raman monitoring under reactive plasma condition. The original analytic tool can be of great importance to monitor the characteristics of these nanostructured materials and readily define the ultimate conditions for targeted results.
Experimental stimulation of veal calf growth by the somatotropic hormone or thyroliberine (1987)

National audience
Assembly of Au colloids into linear and spherical aggregates and effect of ultrasound irradiation on structure (2005)

In this work, we aimed to tune the aggregation state of Au colloids by judicious regulation of their surface charges and by introduction of ultrasound irradiation. Au colloids were prepared by reduction of HAuCl4 with NaBH4 in the presence of 3-mercaptopropionic acid (MPA) as the stabilizing ligand. The Au colloids capped with MPA molecules possessing a single –SH terminal group, can form either linear or spherical Au colloid aggregates depending on the MPA ∶ Au ratio, solution pH and Au colloid concentration. Adjustment of these parameters provides a convenient means of regulating surface charge on the Au colloid surface and, thus, the state and degree of aggregation. The spherical aggregates appeared to be thermodynamically stable, and ultrasound irradiation could promote their formation. Intense ultrasound irradiation resulted in the formation of well-crystallized nanospheres whilst mild irradiation tended to produce a more amorphous product. This is the first observation of a sonication effect on the crystallization state in freely suspended Au colloids in aqueous solution.
THz Seamless Networks for Future Mobile Services (2020)

THz radio links can offer over 10Gbps high-speed wireless transmission, where radio spectrum congestion is not yet so significant in THz bands (0.1-10 THz) [1]. However, even in THz bands, advanced modulation formats would be required as well as in conventional millimeter-wave or microwave bands, to increase spectral efficiency. Spectral efficiency and transmission capacity of THz communication systems will be reviewed in this presentation. We will share a survey result on power consumption of short-distance wireless systems. Power consumption reduction in radio transmitters is also very important to reduce operation cost of networks. The result implies that THz high-speed radio may provide effective transmission. However, the transmission distance of THz transmission should be shorter than a few hundred meters due to attenuation in the air. Thus, we should construct the THz networks consisting of many THz radio-links and optical fibers, which are connected by many media converters. We will discuss issues in such seamless networks. To offer a real-time THz transmission, the Horizon 2020 EU-Japan project ThoR (“TeraHertz end-to-end wireless systems supporting ultra high data Rate applications”) will develop an over 100 Gb/s radio transmission system using frequency band beyond 275 GHz [2]. An ultra-broadband, high linearity THz transmitter at 300 GHz will be demonstrated by using photonic local oscillators, multi-functional THz integrated circuits and traveling-wave tube amplifiers.
Sensitive Detection of Marker Proteins by the Enhanced Fluorescence Technique with a Plasmonic Chip (2022)

Plasmonic chip with a wavelength-size periodic structure can provide the enhanced electric field on the chip surface and therefore, in the fluorescence detection and imaging, the target molecule was sensitively detected with the sandwich immunoassay by the larger fluorescence signal. Here, the hole array-type and Bull's eye-type patterns were used for target detection of S-protein and single exosome, respectively. The capture interface was prepared for suppressing the nonspecific adsorption of labeled-antibody and detection antibody was also considered. The fluorescence was measured with an angle scanning system and a fluorescence microscope. S-protein was detected at 0.1 ng/mL within 40 min. On the other hand, single exosome modified with some kinds of labeled-antibody was detected at the exosome concentration of 47 fM. The combination of the S-protein immunoassay and single exosome detection and analysis method can be applied to detection of SARS-CoV-2 virus.
Theoretical estimates of HVAC duct channel capacity for high-speed Internet access (2003)

We report theoretical channel capacity estimates of heating, ventilation, and air-conditioning (HVAC) ducts based on multi-carrier transmission that uses M-QAM modulation and measured channel responses at 2.4 GHz Industrial, Scientific, and Medical (ISM) band. It is shown that, data rates in excess of 1 Gbps are possible over distances up to 500 m in "matched" ducts (one can think of "matched" ducts as user-friendly ducts, since "matching" can, in principle, eliminate all the multipath reflections in HVAC ducts). Our work also shows that data rates in excess of 300 Mbps are possible over distances up to 500 m even in the presence of significant multipath reflections.
ChemInform Abstract: Synthesis of (2R,3S,4R)‐3,4‐Dihydroxyproline from D‐Ribonolactone: An Approach to the Synthesis of Polyfunctionalized D‐Amino Acids from Sugar Lactones. X‐Ray Molecular Structures of 2‐Azido‐3,4‐O‐(R)‐benzylidene‐2‐deoxy‐D‐ribono‐1,5‐lactone, 2‐Azido‐2‐deoxy‐D‐ribono‐1,4‐lactone, and (2R,3S,3R)‐3,4‐Dihydroxyproline. (1987)

Abstract The key step in the transformation of the title lactone (I) to the amino acid (VIII) is the displacement of the triflate group in compound (IIIb) by an azide group, which occurs with retention of the configuration (for (IIIb) no yields given).
IL-37 Inhibits Inflammasome Activation and Disease Severity in Murine Aspergillosis (2014)

Since IL-37 transgenic mice possesses broad anti-inflammatory properties, we assessed whether recombinant IL-37 affects inflammation in a murine model of invasive pulmonary aspergillosis. Recombinant human IL-37 was injected intraperitoneally into mice prior to infection and the effects on lung inflammation and inflammasome activation were evaluated. IL-37 markedly reduced NLRP3-dependent neutrophil recruitment and steady state mRNA levels of IL-1β production and mitigated lung inflammation and damage in a relevant clinical model, namely aspergillosis in mice with cystic fibrosis. The anti-inflammatory activity of IL-37 requires the IL-1 family decoy receptor TIR-8/SIGIRR. Thus, by preventing activation of the NLRP3 inflammasome and reducing IL-1β secretion, IL-37 functions as a broad spectrum inhibitor of the innate response to infection-mediated inflammation, and could be considered to be therapeutic in reducing the pulmonary damage due to non-resolving Aspergillus infection and disease.
Cloning and Characterization of a Novel Gene,striamin, That Interacts with the Tumor Suppressor Protein p53 (1999)

Expression analysis of a novel cDNA isolated from immortal murine fibroblasts revealed a single transcript of 3.0 kilobase pairs that was highly expressed in mouse and human striated muscle and in mouse heart. The gene has therefore been named striamin. Its expression was confined to skeletal muscle types with a fast glycolytic (2B) contractile phenotype. It was also detected in C2C12 mouse myoblasts and was down-regulated during in vitro myogenesis. The cDNA has a single open reading frame encoding a predicted 16.8-kDa protein of 149 amino acids with no homology to known proteins. Microinjection and transfection of green fluorescence protein-tagged striamin demonstrated that it localizes to the nucleus. Coimmunoprecipitations revealed that it can interact with p53 (a positive marker for myoblast differentiation) in vivo and in vitro. Furthermore, it repressed p53 activity in p53-mediated reporter assays. Fluorescence in situ hybridization with a mouse P1 genomic clone localized the gene to chromosome 12C3, which is syntenic to human chromosome 14q21-22.
Geometrical Optics Solution for Periodic Multilayer Anisotropic Slab Scattering (2020)

In this paper, a Geometrical Optics (GO) solution for electromagnetic scattering from a periodic multilayer anisotropic slab is presented. An approach based on the Transfer Matrix Method (TMM) is used to determine effective slab reflection and transmission coefficients. Numerical results for various scattering problems showing excellent agreement with reference solutions are provided.
Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis (2013)

The novel PET tracer [18F]fluoro-PEG-folate, designed to target FR on activated macrophages provided improved contrast in a rat model of arthritis compared with the accepted macrophage tracer (R)-[11C]PK11195. These results warrant further exploration of [18F]fluoro-PEG-folate as a putative PET tracer for imaging (sub)clinical arthritis in RA patients.
Analysis of mid-positioning BAC filter technology (2011)

BAC filter, placed in the end of process flow in the traditional O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> -BAC advanced treatment process, usually using the same filter type with sand filter, has adsorption effect, biochemical function and filtration function, so it can used to avoid secondary pollution. But problems were found in BAC filter placed after sand filter, such as hidden trouble from microorganism leak and low efficiency of biochemical effect. Placing BAC filter between sediment tank and sand filter, on one hand, most of the turbidity could be removed by coagulation-sediment treatment, which is good for particle activated carbon adsorbing. On the other hand, with sand filter behind it, turbidity in effluent of BAC filter was out of restriction, and it is possible to use the filter type of high up-flow biological aerated filter (HUBAF). A pilot was tested to choose the better flow way, filter media type and gradation, filtration rate , empty bed contact time, oxygen supplying way and backwash way for BAC filter, and a new technology, up-flow aerated biological activated carbon filter (UBACF), was developed, compared with post positioning BAC filter, it can well cope with the condition when the inlet turbidity was high. Meanwhile UBACF keeps the adsorption effect, and the backwash parameters and abrasion rate of activated carbon were almost the same, however, it greatly enhanced oxygen supplying ability and mass transferring efficiency, improved nitrification of NH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> -N and biodegradation of organic.
Variable-angle directional emissometer for moderate-temperature emissivity measurements. (2016)

Abstract not provided.
Arterial hypertension and β-amyloid accumulation have spatially overlapping effects on posterior white matter hyperintensity volume: A cross-sectional study (2022)

Abstract Background Posterior white matter hyperintensities (WMH) in subjects across the Alzheimer’s disease (AD) spectrum with minimal vascular pathology suggests that amyloid pathology—not just arterial hypertension—impacts WMH, adversely influencing cognition. Here we seek to determine the effect of both hypertension and Aβ positivity on WMH, and their impact on cognition. Methods We analysed data from subjects with a low vascular profile and normal cognition (NC), subjective cognitive decline (SCD), and amnestic mild cognitive impairment (MCI) enrolled in the ongoing observational multicentre DZNE Longitudinal Cognitive Impairment and Dementia Study (n=375, median age 70.2 [IQR 66.0-74.4] years; 176 female; NC/SCD/MCI 127/162/86). All subjects underwent a rich neuropsychological assessment. We focused on baseline memory and executive function—derived from multiple neuropsychological tests using confirmatory factor analysis—, baseline preclinical Alzheimer’s cognitive composite 5 (PACC5) scores, and changes in PACC5 scores over course of three years (ΔPACC5). Results Subjects with hypertension or Aβ positivity presented the largest WMH volumes ( p FDR &lt;0.05), with spatial overlap in the frontal (hypertension: 0.42±0.17; Aβ: 0.46±0.18), occipital (hypertension: 0.50±0.16; Aβ: 0.50±0.16), parietal lobes (hypertension: 0.57±0.18; Aβ: 0.56±0.20), corona radiata (hypertension: 0.45±0.17; Aβ: 0.40±0.13), optic radiation (hypertension: 0.39±0.18; Aβ: 0.74±0.19), and splenium of the corpus callosum (hypertension: 0.36±0.12; Aβ: 0.28±0.12). Hypertension, Aβ positivity, and WMH were connected to cognition. First, WMH coincided with worse cognitive performance and outcomes ( p FDR &lt;0.05), regardless of Aβ and hypertension. Accelerated cognitive decline was associated with WMH in the genu of the corpus callosum and segments of the forceps major and inferior fronto-occipital longitudinal fasciculus ( p FDR &lt;0.05). Second, hypertension was indirectly linked to cognitive performance at baseline and over time via splenial WMH ( indirect-only effect ; memory: −0.05±0.02, p FDR =0.029; executive: −0.04±0.02, p FDR =0.067; PACC5: −0.05±0.02, p FDR =0.030; ΔPACC5: −0.09±0.03, p FDR =0.043). Third, the relationship between Aβ positivity and baseline and longitudinal cognitive performance was independent of WMH burden. Conclusions Posterior white matter is susceptible to hypertension and Aβ accumulation and it mediates the association between hypertension and cognitive dysfunction. Posterior WMH could be a promising target to tackle the downstream damage related to the potentially interacting and potentiating effects of the two pathologies. Trial Registration German Clinical Trials Register (DRKS00007966, 04/05/2015)
Structure of an analogue of the steroidal isoxazole danazol, ethyl 17α-ethynyl-17-hydroxy-4-androsteno[2,3-d]isoxazole-3'-carboxylate (1988)

C 25 H 31 NO 4 cristallise dans P2 1 2 1 2 1 avec affinement jusqu'a 0,043. L'heterocycle est plan. Le groupe acetylenique est en position axiale, et sur la face opposee de la molecule, par rapport aux groupes methyl. Existence de liaison hydrogene intermoleculaires O(hydroxy)… O(isoxazole)
On the Feasibility of Imaging Peripheral Nerves Using Acoustic Radiation Force Impulse Imaging (2009)

Regional anesthesia is preferred over general anesthesia for many surgical procedures; however, challenges associated with poor image guidance limit its widespread acceptance as a viable alternative. In B-mode ultrasound images, the current standard for guidance, nerves can be difficult to visualize due to their similar acoustic impedance with surrounding tissues and needles must be aligned within the imaging plane at limited angles of approach that can impede successful peripheral nerve anesthesia. These challenges lead to inadequate regional anesthesia, necessitating intraoperative interventions, and can cause complications, including hemorrhage, intraneural injections and even nerve paralysis. ARFI imaging utilizes acoustic radiation force to generate images that portray relative tissue stiffness differences. Peripheral nerves are typically surrounded by many different tissue types (e.g., muscle, fat and fascia) that provide a mechanical basis for improved image contrast using ARFI imaging over conventional B-mode images. ARFI images of peripheral nerves and needles have been generated in cadaveric specimens and in humans in vivo. Contrast improvements of >600% have been achieved for distal sciatic nerve structures. The brachial plexus has been visualized with improved contrast over B-mode images in vivo during saline injection and ARFI images can delineate nerve bundle substructures to aid injection guidance. Physiologic motion during ARFI imaging of nerves near arterial structures has been successfully suppressed using ECG-triggered image acquisition and motion filters. This work demonstrates the feasibility of using ARFI imaging to improve the visualization of peripheral nerves during regional anesthesia procedures.
An investigator blinded cross-over study to characterize the cutaneous effects and suitability of modern sanitary pads for menstrual protection for women residing in the USA (2011)

These results revalidate the results of a previous clinical study in the United States and are consistent with recent reports of worldwide clinical trials of high performance sanitary pads.
Effect of Disodium Etidronate (EHDP) on Bone Ingrowth in a Porous Material (1987)

This study evaluated the effect of disodium etidronate (EHDP) on biomechanical and histologic characteristics of bone ingrowth in a porous material. EHDP was administered parenterally to six adult mongrel dogs at a dose of 2 mg/kg/day for eight weeks. Six additional dogs served as controls and were injected with saline. Porous titanium fiber composites were inserted into the proximal humeri and the left olecranons of all animals after the first four weeks of treatment. Upon completing a total of eight weeks of treatment, all animals were sacrificed and the bone-porous implant interfacial shear strength was determined by a pull-out test to failure. Mean shear strength of fixation for the EHDP-treated group was reduced by 76% compared to the control group (p less than 0.001). Bone ingrowth was mineralized in all of the control specimens. Mineralization of tissue ingrowth was inhibited, however, in all specimens from EHDP-treated animals. These findings suggest that cementless skeletal fixation of porous-coated implants by bone ingrowth may be delayed or prevented by the administration of EHDP.
Review—Electrochemical Biosensors for Interleukins: Electrode Materials (2023)

Interleukins gained great interest as potential biomarkers for autoimmune diseases, cancers, and viral infections. Challenges faced in the detection of interleukins include their minute concentrations in biological specimens, the need to generate quantitative results, and multi-analyte measurement for differential diagnosis. The properties of the material of the working electrode are crucial for signal transduction. Consequently, different working electrode materials were investigated to select the ones which generate the highest signal and ensure the reproducibility of the results and the robustness of the biosensor. In this review, the interleukin electrochemical biosensors developed since 2015 were classified according to the material of the working electrode into noble metals, ceramics, and carbon-based materials. The advantages and limitations of each working electrode material are discussed. Designs and performance criteria of interleukin electrochemical biosensors developed since 2015 are compared with reference to the type of working electrode material including those made of hybrid ones.