gebhart/patrepeval huggingface dataset:
Interaction between the oculomotor and postural systems during a dual-task: Compensatory reductions in head sway following visually-induced postural perturbations promote the production of accurate double-step saccades in standing human adults (2017)

Humans routinely scan their environment for useful information using saccadic eye movements and/or coordinated movements of the eyes and other body segments such the head and the torso. Most previous eye movement studies were conducted with seated subject and showed that single saccades and sequences of saccades (e.g. double-step saccades) made to briefly flashed stimuli were equally accurate and precise. As one can easily appreciate, most gaze shifts performed daily by a given person are not produced from a seated position, but rather from a standing position either as subjects perform an action from an upright stance or as they walk from one place to another. In the experiments presented here, we developed a new dual-task paradigm in order to study the interaction between the gaze control system and the postural system. Healthy adults (n = 12) were required to both maintain balance and produce accurate single-step and double-step eye saccades from a standing position. Visually-induced changes in head sway were evoked using wide-field background stimuli that either moved in the mediolateral direction or in the anteroposterior direction. We found that, as in the seated condition, single- and double-step saccades were very precise and accurate when made from a standing position, but that a tighter control of head sway was necessary in the more complex double-step saccades condition for equivalent results to be obtained. Our perturbation results support the "common goal" hypothesis that state that if necessary, as was the case during the more complex oculomotor task, context-dependent modulations of the postural system can be triggered to reduced instability and therefore support the accomplishment of a suprapostural goal.
A254 IDENTIFICATION OF THE TLR-LIKE RECEPTOR CD180 AND THE ACCESSORY MOLECULE MD-1 DUCK HOMOLOGUES FOR THERAPEUTIC TARGETING IN THE DUCK HEPATITIS B INFECTION MODEL (2019)

Hepatitis B infection is a leading cause of liver disease with over 240 million chronic carriers. Current protective vaccines elicit protective immune responses in up to 95% of healthy adults but are poorly immunogenic in immunocompromised individuals and there are currently no effective therapeutic vaccines available. CD180, also known as radioprotective 105 kDa protein (RP105), is a Toll-like receptor (TLR), type-1 glycoprotein expressed on antigen presenting cells (APC) in complex with the accessory molecule MD-1. Engagement of antibodies with CD180 promotes proliferation of B cells, and targeting of antigen to CD180 has been shown to enhance antigen-specific B cell and T cell responses. The aim of this project is to clone the duck CD180 and MD-1 cDNA and to characterize the expressed protein. The duck CD180 (duCD180) and duck MD-1 (duMD-1) cDNAs were obtained by RT-PCR and RACE. The open reading frame of duMD-1 and duCD180 were inserted in eukaryotic expression vectors in frame with distinct carboxy- and amino-terminal purification/detection tags, and expression was verified in 293T cells by immunoblot. The duCD180 cDNA encodes a 660 amino acid (aa) protein that has an aa identity of 52%, 49% and 81% with the respective human, mouse and chicken homologues, whereas the duMD-1 cDNA encodes a 161 aa protein that has an aa identity of 42%, 42% and 84% with human, mouse and chicken MD-1, respectively. Using anti-His6/anti-FLAG antibodies duCD180 and duMD-1 were detected in cell lysates but not culture supernatants of transfected 293T cells. Our observations suggest significant evolutionary conservation of both CD180 and MD-1 between mammalian and avian homologue proteins. This project will lay the foundation for exploration of CD180-targed immunization studies in the duck hepatitis B infection model. internal funding
High-performance non-volatile field-effect transistor memories using an amorphous oxide semiconductor and ferroelectric polymer (2016)

High-performance Fe-FET memories using InSiO and P(VDF–TrFE) as the semiconductor and dielectric, respectively, were fabricated with a carrier mobility of 84.1 cm V<sup>−1</sup> s<sup>−1</sup>.
SPICE simulation of 1T1R structures based on a logistic hysteresis operator (2017)

In this paper a SPICE (Simulation Program with Integrated Circuit Emphasis) implementation of a memristor model able to describe the major and minor current-voltage loops in bipolar resistive switches is reported. In particular, this work addresses the implementation of one transistor-one resistor (1T1R) structures for RRAM applications by means of SPICE simulations. Specifically, the dependence of the low-resistive state on the compliance current is investigated. The model is based on the combination of a diode-like device as the switching element and the logistic hysteron formalism for the memory effect. It is shown how the proposed circuit for the 1T1R structure reproduces the main features of the experimental output curves.
Dynamic function and imaging in the analysis of osteoarthritis at the knee (2002)

Degenerative changes to the articular cartilage at the knee are caused by the complex interactions between the biology, structural properties and the mechanical environment of the articular cartilage. Understanding the causes of degenerative changes to the articular cartilage is confounded by the capacity of biological systems to adapt to early pathological changes. These adaptive changes occur over a broad range of scales from micro levels (e.g. alterations in cell metabolism) to macro levels (e.g changes in the pattern of locomotion). The nature of these adaptive changes provides a potential explanation for the large differences in the rate of progression of osteoarthritis (OA) at the knee joint.
Automated, controlled deposition of nanoparticles on polyelectrolyte-coated silicon from chemomechanically patterned droplet arrays (2004)

This paper describes three advances in lab on a chip technology. First, it is shown that chemomechanical surface patterning can be performed using a commercially available liquid handler that has undergone only minor modifications. These capabilities are demonstrated by making and then characterizing smaller hydrophobic corrals, made with a diamond tip, than have previously been reported. Hydrophobic corrals are small enclosures on a surface that are ringed by hydrophobic lines. They hold droplets of high surface tension solutions. They allow a surface to be subdivided into individually addressable elements, thus providing a platform for conducting many simultaneous surface experiments with small (down to ca. 1 microL) liquid volumes. An important consequence of this work is that it makes chemomechanical surface patterning, which is a valuable and straightforward method for surface modification, much more accessible to the technical community. Second, it is shown that an entire array of hydrophobic corrals can be simultaneously coated with polyelectrolyte multilayers, but that the hydrophobic corrals still retain the ability to hold liquids after this deposition. The robotic arm of the liquid handler is again employed to manufacture this ultrathin film. Finally, as a demonstration of the capability of this technology to create complex patterned arrays on surfaces from solution for biological or nanostructured materials applications, and again employing the liquid handler, polyelectrolyte-coated hydrophobic corrals are individually addressed and loaded with a solution containing gold nanoparticles for independently specified times. The density and morphology of deposited nanoparticle monolayers were studied by scanning electron microscopy. The deposition of gold nanoparticles onto a chip occurred at a constant rate (0.5% min(-1)) over the range of times studied.
Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement (2022)

Brief Summary: An international panel of experts produced this consensus statement after critical review of the existing evidence on the safety of GH replacement in cancer and intracranial tumour survivors and in patients with increased cancer risk.
Photochemical Processing of Polymer Films with Excimer Laser. (1994)

紫外レーザーであるエキシマレーザーを使用して,高分子材料の超精密エッチングや新たな表面改質技術が生まれている.フッ素樹脂の親水化による微細なパターンの無電解めっき法も見い出された.ここでは,高分子の爆発的な分解反応であるアブレーションの利用や高分子膜表面での光化学反応の活用による高分子材料の高機能化を紹介する.
Orthogonal Cu- and Pd-Based Catalyst Systems for the O- and N-Arylation of Aminophenols (2009)

O- or N-arylated aminophenol products constitute a common structural motif in various potentially useful therapeutic agents and/or drug candidates. We have developed a complementary set of Cu- and Pd-based catalyst systems for the selective O- and N-arylation of unprotected aminophenols using aryl halides. Selective O-arylation of 3- and 4-aminophenols is achieved with copper-catalyzed methods employing picolinic acid or CyDMEDA, &lt;i&gt;trans&lt;/i&gt;-&lt;i&gt;N&lt;/i&gt;,&lt;i&gt;N&lt;/i&gt;′-dimethyl-1,2-cyclohexanediamine, respectively, as the ligand. The selective formation of N-arylated products of 3- and 4-aminophenols can be obtained with BrettPhos precatalyst, a biarylmonophosphine-based palladium catalyst. 2-Aminophenol can be selectively N-arylated with CuI, although no system for the selective O-arylation could be found. Coupling partners with diverse electronic properties and a variety of functional groups can be selectively transformed under these conditions.
ELLIPSO - Coverage optimization using elliptic orbits (1994)

The conceptual approach to designing the ELLIPSO'* mobile sate1 1 ite system (MSS) constellation is described. It is shown that constellations can be biased to satisfy subscriber geographic and time of day coverage requirements through the use of tailored elliptic orbits instead of circular orbits. The resulting constellations use fewer satellites than comparable circular orbit constellations, promoting cost savings in both satellites and launch vehicles.
Sixteen-Membered Macrolides: Chemical Modifications and Future Applications (2013)

To produce a novel macrolide antibiotic, which is biologically stable and effective against erythromycin-resistant Streptococcus pneumoniae constitutively expressing the erm gene, we designed and synthesized a variety of novel macrolides starting from 16-membered macrolides.Initially, metabolically stable 16-membered macrolides were produced by constructing a 4-O-alkylated cladinose moiety as a stable neutral sugar.Then, an arylalkyl group was introduced to the lactone ring to improve the antibacterial activities against resistant S. pneumoniae.Although the novel analogues, which possess an arylalkyl group at the C-3 position or the western hemisphere improved antibacterial activities against inducible resistant and efflux type S. pneumoniae, they did not have sufficient activities against constitutive erm-resistant S. pneumoniae.Further, exploration of a novel macrolactone led to identification of a unique 11-azalide framework.We systematically synthesized 14-to 16-membered azalides and azalactams, and a 16-membered azalide (azalactone) was selected as a template for further medicinal chemistry.Finally, we optimized the connecting position of an arylalkyl group, structure of an arylalkyl moiety, and a neutral sugar moiety, and we synthesized a novel 15--substituted 16-membered 11-azalide, which was biologically stable and effective against constitutive erm-resistant S. pneumoniae.
Abstract B17: The small RhoGTPase RhoB as a new potential marker of EGFR-TKI resistance (2012)

Abstract Introduction: EGFR tyrosine kinase inhibitors (EGFR-TKI) are widely used in metastatic non small cell lung cancer (NSCLC). Nevertheless, the majority of patients with wild type EGFR do not respond to these treatments and, in the selected group with EGFR mutations, we some primary resistance and all the patients will ultimately develop acquired resistance. The small RHO GTPase RhoB is involved in cell proliferation, invasion, apoptosis and can act as a tumor suppressor gene in lung carcinogenesis by controlling survival and invasion through AKT pathway. Furthermore, RhoB participates in the regulation of endocytic trafficking of EGFR. Specifically, activated RhoB is able to delay the transport of internalized EGFR to lysosomes, thus modifying its downstream signaling. The objective of our study is to know if RhoB is a molecular determinant of the response to the EGFR-TKI erlotinib, and if RhoB could be a marker for erlotinib resistance. Material and Method: We used various lung cancer cell lines harboring either wild-type or mautated EGFR and K-Ras. RhoB was either overexpressed by adenovirus transfection or inhibited by interfering RNA (siRNA) in these cells. Cell proliferation after 72h of treatment with erlotinib was measured by a colorimetric assay. In the same way, we performed invasion assays and western-blot analyses of downtsream signaling pathways. Results: (1) RhoB overexpression decreases the sensitivity to erlotinib of cells presenting a wild type or mutated EGFR in a dose-dependent manner whereas the sensitivity to erlotinib of cells bearing KRas mutation was not affected by RhoB overexpression. (2) Erlotinib-induced inhibition of cellular invasion is impaired by overexpression of RhoB in wild type or mutated EGFR cell lines. (3) The phosphorylation of Akt (and not of ERK) is inhibited by erlotinib and is restored upon overexpression of RhoB invasion. Conclusions: Our results suggest that RhoB is involved in the sensitivity to erlotinib in wild-type K-Ras cells harboring either mutated or wild-type EGFR. RhoB is able to block erlotinib-induced inhibition of cell proliferation and invasion mainly through AKT pathway modulation. We plan to extend our in vitro findings in a cohort of patients treated with erlotinib.
ChemInform Abstract: Conformational Analysis of 1,2:3,4‐Diepoxides: ab initio and Semiempirical Molecular‐Orbital Calculations. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Alteration of the tertiary structure of the major bee venom allergen Api m 1 by multiple mutations is concomitant with low IgE reactivity (2004)

We have engineered a recombinant form of the major bee venom allergen (Api m 1) with the final goal of reducing its IgE reactivity. This molecule (Api mut) contains 24 mutations and one deletion of 10 amino acids. The successive introduction of these sequence modifications led to a progressive loss of specific IgE and IgG reactivity and did not reveal any immunodominant epitopes. However, Api mut exhibited a clear loss of reactivity for Api m 1-specific IgE and IgG. Injection of Api mut into mice induced specific antibody production. This humoral response was as high as that induced by the Api m 1 but the cross-reactivity of the antibodies was weak. As inferred by far UV circular dichroism, this mutant was correctly folded. However, near UV circular dichroism and denaturation curves of Api mut showed that it exhibits a dynamic tertiary structure and that it is a highly flexible molecule. Finally, as all the sequence modifications have been introduced outside the human and murine T cell epitope regions, we investigated its T cell properties in mice. We showed that Api mut-specific T lymphocytes induced in vivo were stimulated in vitro by both proteins. These data provide new insights in the design of hypoallergenic molecules.
K-gram based software birthmarks (2005)

Software birthmarking relies on unique characteristics that are inherent to a program to identify the program in the event of suspected theft. In this paper we present and empirically evaluate a novel birthmarking technique which uniquely identifies a program through instruction sequences. To evaluate the strength of the birthmarking technique we examine two properties: credibility and resilience to semantics-preserving transformations. We show that the technique provides both high credibility and resilience. Additionally, it complements previously proposed static birthmarking techniques.
ChemInform Abstract: A Concise Synthesis of Rooperol and Related 1,5‐Diarylpent‐1‐en‐4‐ynes. (2014)

Abstract A short five‐step synthesis of rooperol (IX) is presented starting from perchlorocyclopropene (I).
Supplementary Figure 6 from Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies (2023)

&lt;p&gt;PDF file - 231K, Analysis of the combined therapeutic effects of radiotherapy and alpha-OX40 monoclonal antibody treatment in established subcutaneous 4T1.2 (A) and AT-3 (B) tumors&lt;/p&gt;
100k Cycles and Beyond: Extraordinary Cycle Stability for MnO2 Nanowires Imparted by a Gel Electrolyte (2016)

We demonstrate reversible cycle stability for up to 200 000 cycles with 94–96% average Coulombic efficiency for symmetrical δ-MnO2 nanowire capacitors operating across a 1.2 V voltage window in a poly(methyl methacrylate) (PMMA) gel electrolyte. The nanowires investigated here have a Au@δ-MnO2 core@shell architecture in which a central gold nanowire current collector is surrounded by an electrodeposited layer of δ-MnO2 that has a thickness of between 143 and 300 nm. Identical capacitors operating in the absence of PMMA (propylene carbonate (PC), 1.0 M LiClO4) show dramatically reduced cycle stabilities ranging from 2000 to 8000 cycles. In the liquid PC electrolyte, the δ-MnO2 shell fractures, delaminates, and separates from the gold nanowire current collector. These deleterious processes are not observed in the PMMA electrolyte.
DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome (2018)

The importance of Discoidin Domain Receptor 1 (DDR1) in renal fibrosis has been shown via gene knockout and use of antisense oligonucleotides; however, these techniques act via a reduction of DDR1 protein, while we prove the therapeutic potential of inhibiting DDR1 phosphorylation with a small molecule. To date, efforts to generate a selective small-molecule to specifically modulate the activity of DDR1 in an in vivo model have been unsuccessful. We performed parallel DNA encoded library screens against DDR1 and DDR2, and discovered a chemical series that is highly selective for DDR1 over DDR2. Structure-guided optimization efforts yielded the potent DDR1 inhibitor 2.45, which possesses excellent kinome selectivity (including 64-fold selectivity over DDR2 in a biochemical assay), a clean in vitro safety profile, and favorable pharmacokinetic and physicochemical properties. As desired, compound 2.45 modulates DDR1 phosphorylation in vitro as well as prevents collagen-induced activation of renal epithelial cells expressing DDR1. Compound 2.45 preserves renal function and reduces tissue damage in Col4a3<sup>-/-</sup> mice (the preclinical mouse model of Alport syndrome) when employing a therapeutic dosing regime, indicating the real therapeutic value of selectively inhibiting DDR1 phosphorylation in vivo. Our results may have wider significance as Col4a3<sup>-/-</sup> mice also represent a model for chronic kidney disease, a disease which affects 10% of the global population.
The Miller-Galante total knee arthroplasty:Evaluation of design, surgical technique, indications, and clinical results (1991)

The design rationale of the cementless Miller-Galante 1 total knee prosthesis included preservation of the posterior cruciate ligament, anatomically sized tibial and femoral components, stable initial fixation of the components to promote bone ingrowth, and instrumentation that allowed reconstruction of the limb's mechanical axis with reproducible bone surface preparation for intimate contact of porous surface to bone. A comparison of the cemented and cementless Miller-Galante 13- to 6-year results displayed ± 10% incidence of cementless patellar failure. The patellofemoral articulation was redesigned in the Miller-Galante II prosthesis along with changes in the polyethylene bearing surface, tibial fixation, and femoral component surface finish. These changes are discussed along with the authors' preferred surgical technique and current indications for cementless total knee arthroplasty.
A Superhydrophobic Coating Based on Onion-Like Carbon Nanoparticles (2020)

For the first time, a superhydrophobic coating based on onion-like carbon was synthesized by an economically feasible and scalable method was obtained. Two simple and easily reproducible methods of application are proposed. The possibility of using such coating to detect the composition and humidity of the air as well as its anti-icing properties are studied.
ADAPTIVE BI-PREDICTIVE VIDEO CODING USING TEMPORAL EXTRAPOLATION (2003)

In this paper, we propose a new multi-frame bi-predictive motion compensation method using a temporal linear extrapolation technique. Significant coding gain is obtained by the proposed method, especially for fading or dissolving scenes, which are among the most difficult scenes to compress by conventional coding standards. Moreover, stable improved coding efficiency is obtained, using block by block adaptation combined with multiframe averaging prediction. The number of reference frames for the proposed temporal prediction method is limited to two successive frames which are already coded. And therefore only addition, subtraction and shift operation are needed to generate the prediction signal of both extrapolation and averaging. As for encoding, automatic adaptation is performed without scene characteristics detection, such as fade-in, fade-out, and dissolve. Therefore, additional computational power for both encoder and decoder to use the proposed method is very small.
Hydrogen Peroxide Induced Activation of Gene Expression in Mammalian Cells using Boronate Estrone Derivatives (2012)

Keeping the boron out of the ER: A genetic switch was engineered that activates gene expression in the presence of H(2)O(2). The use of a boronate group on an estrone molecule allows for activation of gene expression through binding of the estrogen receptor only when the boron group is oxidized by H(2)O(2). This sensor is highly sensitive and specific for H(2)O(2).
Boiling histotripsy lesion characterization on a clinical magnetic resonance imaging-guided high intensity focused ultrasound system (2017)

Our characterization of effects of HIFU sonication parameters on the resulting lesion demonstrates the ability to control lesion morphologic and thermal characteristics with a clinical MR-HIFU system in TMP's and ex vivo tissues. We demonstrate that this system can produce spatially precise lesions in both phantoms and ex vivo tissues. The results provide guidance on a preliminary set of BH sonication parameters for this system, with a potential to facilitate BH translation to the clinic.
Patterning and Imaging at the Nanoscale with Far-field Optics via Absorbance Modulation (2007)

By illuminating an absorbance-modulation layer with a null at one wavelength, and a focused spot at another wavelength, it is possible to overcome the diffraction limit. We present preliminary experimental results, and rigorous theoretical simulations.
Multiple C−H Bond Activation. Threefold-Deprotonated 6-Phenyl-2,2‘-bipyridine as a Bridging Ligand in Dinuclear Platinum(II) Derivatives (2002)

Unusual platinum(II) trimetalated derivatives have been synthesized and characterized by reaction of cis-[Pt(R)2(DMSO)2] (R = Me, Ph) and 6-phenyl-2,2‘-bipyridine. The behavior of the substituted 2,2‘-bipyridine as a threefold-deprotonated ligand is unprecedented.