gebhart/patrepeval huggingface dataset:
Closed-loop separation control using oscillatory flow excitation (2000)

Design and implementation of a digital feedback controller for a flow control experiment was performed. The experiment was conducted in a cryogenic pressurized wind tunnel on a generic separated configuration at a chord Reynolds number of 16 million and a Mach number of $0.25$. The model simulates the upper surface of a $2 airfoil at zero angle-of-attack. A moderate favorable pressure gradient, up to $5 pressure gradient which is relaxed towards the trailing edge. The turbulent separation bubble, behind the adverse pressure gradient, is then reduced by introducing oscillatory flow excitation just upstream of the point of flow separation. The degree of reduction in the separation region can be controlled by the amplitude of the oscillatory excitation. A feedback controller was designed to track a given trajectory for the desired degree of flow reattachment and to improve the transient behavior of the flow system. Closed-loop experiments demonstrated that the feedback controller was able to track step input commands and improve the transient behavior of the open-loop response.
Real-time analysis of the binding of fluorescent VEGF 165 a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes (2017)

Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. Here we have used a novel stoichiometric protein-labeling method to generate a fluorescent variant of VEGF (VEGF<sub>165</sub>a-TMR) labeled on a single cysteine within each protomer of the antiparallel VEGF homodimer. VEGF<sub>165</sub>a-TMR has then been used in conjunction with full length VEGFR2, tagged with the bioluminescent protein NanoLuc, to undertake a real time quantitative evaluation of VEGFR2 binding characteristics in living cells using bioluminescence resonance energy transfer (BRET). This provided quantitative information on VEGF-VEGFR2 interactions. At longer incubation times, VEGFR2 is internalized by VEGF<sub>165</sub>a-TMR into intracellular endosomes. This internalization can be prevented by the receptor tyrosine kinase inhibitors (RTKIs) cediranib, sorafenib, pazopanib or vandetanib. In the absence of RTKIs, the BRET signal is decreased over time as a consequence of the dissociation of agonist from the receptor in intracellular endosomes and recycling of VEGFR2 back to the plasma membrane.
Continuous Production of Glucose Syrup in an Ultrafiltration Reactor (1992)

ABSTRACT An ultrafiltration reactor was developed for the continuous saccharification of liquefied corn starch using glucoamylase. At an enzyme concentration of 1 g/L and a substrate concentration of 300 g/L, maltose and maltotriose were still detected in the reactor permeate after 4 hr of operation. At higher enzyme concentrations (6 and 12 g/L), the reactor achieved steady‐state operation within 1–3 hr at all substrate concentrations studied. At an enzyme concentration of 12 g/L, residence time did not affect the final conversion of liquefied starch to glucose. The ultrafiltration reactor produced glucose syrups at residence times of 2–3 hr and substrate concentrations up to 30% w/v.
Virtual Reference Feedback Tuning for non-linear systems (2006)

This paper introduces the VRFT - Virtual Reference Feedback Tuning - approach for controller tuning in a nonlinear set-up. VRFT is a data-based method that permits to directly select the controller based on data, with no need for a model of the plant, and represents a very appealing controller design methodology for many industrial control applications.
Co-Adsorption of Ammonia and Formaldehyde on Regenerable Carbon Sorbents for the Primary Life Support System (PLSS) (2016)

Results are presented on the development of a reversible carbon sorbent for trace-contaminant (TC) removal for use in Extravehicular Activities (EVAs), and more specifically in the Primary Life Support System (PLSS). The current TC-control technology involves the use of a packed bed of acid-impregnated granular charcoal, which is deemed non-regenerable, while the carbon-based sorbent under development in this project can be regenerated by exposure to vacuum at room temperature. Data on concurrent sorption and desorption of ammonia and formaldehyde, which are major TCs of concern, are presented in this paper. A carbon sorbent was fabricated by dry impregnation of a reticulated carbon-foam support with polyvinylidene chloride, followed by carbonization and thermal oxidation in air. Sorbent performance was tested for ammonia and formaldehyde sorption and vacuum regeneration, with and without water present in the gas stream. It was found that humidity in the gas phase enhanced ammonia-sorption capacity by a factor larger than two. Co-adsorption of ammonia and formaldehyde in the presence of water resulted in strong formaldehyde sorption (to the point that it was difficult to saturate the sorbent on the time scales used in this study). In the absence of humidity, adsorption of formaldehyde on the carbon surface was found to impair ammonia sorption in subsequent runs; in the presence of water, however, both ammonia and formaldehyde could be efficiently removed from the gas phase by the sorbent. The efficiency of vacuum regeneration could be enhanced by gentle heating to temperatures below 60 deg.
Data from Enhancement of Human Cancer Cell Motility and Invasiveness by Anaphylatoxin C5a via Aberrantly Expressed C5a Receptor (CD88) (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; The anaphylatoxin C5a is a chemoattractant that induces leukocyte migration via C5a receptor (C5aR). There is emerging evidence that C5a is generated in the cancer microenvironment. We therefore sought C5aR expression and a direct influence of the C5a–C5aR axis on cancer cells.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; C5aR expression was investigated in human cancer tissues and cell lines. Effects of C5a stimulation on cancer cells were studied by cytoskeletal rearrangement, time-lapse analysis, Matrigel chamber assay, and invasion in nude mouse in a comparison of C5aR-expressing cancer cells with control cells.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; C5aR was aberrantly expressed in various human cancers. Several cancer cell lines also expressed C5aR. C5a triggered cytoskeletal rearrangement and enhanced cell motility three-fold and invasiveness 13-fold of C5aR-expressing cancer cells. Such enhancement by C5a was not observed in control cells. Cancer cell invasion was still enhanced in the absence of C5a concentration gradient and even after the removal of C5a stimulation, suggesting that random cell locomotion plays an important role in C5a-triggered cancer cell invasion. C5a increased the release of matrix metalloproteinases (MMP) from cancer cells by two- to 11-fold, and inhibition of MMP activity abolished the C5a-enhancing effect on cancer cell invasion. Compared with control cells, C5aR-expressing cells spread 1.8-fold more broadly at implanted nude mouse skin sites only when stimulated with C5a.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; These results illustrate a novel activity of the C5a–C5aR axis that promotes cancer cell invasion through motility activation and MMP release. Targeting this signaling pathway may provide a useful therapeutic option for cancer treatment. &lt;i&gt;Clin Cancer Res; 19(8); 2004–13. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Considerations for Multi-User Decomposition of Design Spaces (2013)

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.
Evaluation of plate electrodes for laser-enhanced ionization spectrometry (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvaluation of plate electrodes for laser-enhanced ionization spectrometryGeorge J. Havrilla and Robert B. GreenCite this: Anal. Chem. 1980, 52, 14, 2376–2383Publication Date (Print):December 1, 1980Publication History Published online1 May 2002Published inissue 1 December 1980https://pubs.acs.org/doi/10.1021/ac50064a032https://doi.org/10.1021/ac50064a032research-articleACS PublicationsRequest reuse permissionsArticle Views26Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Palladium-Catalyzed Coupling Reaction of 3-Bromo Benzo[b]furan, -thiophene and -selenophene 2-Carboxaldehyde. Preparation of Tetracyclic Heteroaromatic Derivatives (2006)

3-Oxo-2,3-dihydrobenzo[b]furans, -thiophenes and -selenophenes 1a - c afforded the bromo-aldehydes 2 under Vilsmeier-Haack-Arnold conditions. Palladium-catalysed aryl-aryl coupling of 2 with o-formyl-phenylboronic acid allowed the formation of dialdehydes 3 which underwent McMurry cyclisation or pinacol condensation to yield polycyclic aromatic derivatives 4 or the dihydroxylated compounds 5
Orthogonal UCHT sequences for asynchronous CDMA system (2002)

The orthogonal signature sequences in code division multiple access (CDMA) communications systems importantly influences how much interference from other users is received in a receiver, thus determining the overall performance of the system. In this paper, new sets of orthogonal sequences derived from the unified complex Hadamard transforms (UCHT) are proposed and studied. The various correlation properties of the sequences are presented for the first time. Finally, the performance of the UCHT sequences with other known sequences is compared.
Advanced High‐Voltage All‐Solid‐State Li‐Ion Batteries Enabled by a Dual‐Halogen Solid Electrolyte (2021)

Abstract Solid‐state electrolytes (SEs) with high anodic (oxidation) stability are essential for achieving all‐solid‐state Li‐ion batteries (ASSLIBs) operating at high voltages. Until now, halide‐based SEs have been one of the most promising candidates due to their compatibility with cathodes and high ionic conductivity. However, the developed chloride and bromide SEs still show limited electrochemical stability that is inadequate for ultrahigh voltage operations. Herein, this challenge is addressed by designing a dual‐halogen Li‐ion conductor: Li 3 InCl 4.8 F 1.2 . F is demonstrated to selectively occupy a specific lattice site in a solid superionic conductor (Li 3 InCl 6 ) to form a new dual‐halogen solid electrolyte (DHSE). With the incorporation of F, the Li 3 InCl 4.8 F 1.2 DHSE becomes dense and maintains a room‐temperature ionic conductivity over 10 −4 S cm −1 . Moreover, the Li 3 InCl 4.8 F 1.2 DHSE exhibits a practical anodic limit over 6 V (vs Li/Li + ), which can enable high‐voltage ASSLIBs with decent cycling. Spectroscopic, computational, and electrochemical characterizations are combined to identify a rich F‐containing passivating cathode‐electrolyte interface (CEI) generated in situ, thus expanding the electrochemical window of Li 3 InCl 4.8 F 1.2 DHSE and preventing the detrimental interfacial reactions at the cathode. This work provides a new design strategy for the fast Li‐ion conductors with high oxidation stability and shows great potential to high‐voltage ASSLIBs.
Night vision in a case of vitamin A deficiency due to malabsorption. (1983)

Night vision was tested electroretinographically and psychophysically in a vitamin A deficient patient before and after therapy. Vitamin A deficiency resulted from malabsorption due to a jeujunoileal bypass operation. Before therapy the patient had severely reduced cone and rod function. After the reversal operation, accompanied by 5 injections of a total of 500,000 units of vitamin A, complete recovery of cone and rod functions was observed within 7 months. Shortly after therapy rod sensitivity reached the normal level, while the time course of rod adaptation remained slower than normal and the dark-adapted electroretinographic (ERG) responses were subnormal. At later stages the ERG responses reached normal amplitudes but rod adaptation stayed slow. Only after 7 months did night vision reach the normal level with regard to the time course of rod adaptation, rod sensitivity, and ERG responses.
Supplementary Figure 3 from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors (2023)

&lt;p&gt;PDF file - 255K, Effective inhibition of in vitro tumor cell migration by EMD 1214063 and EMD 1204831. A classical "wound healing" test was performed to assess the impact of EMD 1214063 (A) and EMD 1204831 (B) on tumor cell migration. In brief, H441 lung cancer cells were seeded on day 1 (3 x 105 cells/well in 24-well plate), serum-starved on day 2, and treated on day 3 with the indicated concentrations of the EMD compounds for 1 h. After "scratching" the cell layer, cells were incubated in serum-free medium containing 100 ng/mL HGF and the indicated concentrations of the compounds for 24h. Controls were untreated cells with (left) or without HGF (right). At 0 h and 24 h, cells were washed, fixed with ice-cold methanol, and stained with crystal violet (0.05% in 50% ethanol). Treatment with EMD 1214063 or EMD 1204831 resulted in a strong inhibition of tumor cell migration, preventing wound healing. Pictures were taken at 5x magnification. Data are representative of two independent experiments.&lt;/p&gt;
Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome (2021)

The interdependence between thyroid hormones (THs), namely, thyroxine and triiodothyronine, and immune system is nowadays well-recognized, although not yet fully explored. Synthesis, conversion to a bioactive form, and release of THs in the circulation are events tightly supervised by the hypothalamic-pituitary-thyroid (HPT) axis. Newly synthesized THs induce leukocyte proliferation, migration, release of cytokines, and antibody production, triggering an immune response against either sterile or microbial insults. However, chronic patho-physiological alterations of the immune system, such as infection and inflammation, affect HPT axis and, as a direct consequence, THs mechanism of action. Herein, we revise the bidirectional crosstalk between THs and immune cells, required for the proper immune system feedback response among diverse circumstances. Available circulating THs do traffic in two distinct ways depending on the metabolic condition. Mechanistically, internalized THs form a stable complex with their specific receptors, which, upon direct or indirect binding to DNA, triggers a genomic response by activating transcriptional factors, such as those belonging to the Wnt/β-catenin pathway. Alternatively, THs engage integrin αvβ3 receptor on cell membrane and trigger a non-genomic response, which can also signal to the nucleus. In addition, we highlight THs-dependent inflammasome complex modulation and describe new crucial pathways involved in microRNA regulation by THs, in physiological and patho-physiological conditions, which modify the HPT axis and THs performances. Finally, we focus on the non-thyroidal illness syndrome in which the HPT axis is altered and, in turn, affects circulating levels of active THs as reported in viral infections, particularly in immunocompromised patients infected with human immunodeficiency virus.
Autoimmune demyelination in transgenic E alpha d-positive A.CA mice. Comparison with E-negative A.CA mice. (1992)

A body of literature exists implicating the major histocompatibility complex class II E molecule in development of immune tolerance and/or immunosuppression. To define better the regulatory mechanisms underlying susceptibility to experimental autoimmune encephalomyelitis, an autoimmune condition displaying major histocompatibility complex-II dependence, disease was induced in transgenic mice expressing a major histocompatibility complex-II E alpha d-transgene. This was compared with experimental autoimmune encephalomyelitis induced in age-matched E-negative, non-transgenic mice of the same strain. The results showed that experimental autoimmune encephalomyelitis could be induced by adoptive transfer methodology in both transgenic and non-transgenic mice of the A.CA (H-2f) strain. Virtually no differences were observed between the two mouse types with regard to disease onset, course, and neuropathology. The main difference noted was within nonirradiated recipient subgroups where the nonirradiated transgenic A.CA mice demonstrated greater inflammation and demyelination than the nonirradiated, non-transgenic mice throughout the disease course. Thus, the results did not support the idea that the E molecule, per se, is involved in the induction of tolerance or immunosuppressive mechanisms protecting against autoimmunity. In addition, histologic changes in the central nervous system of the A.CA strain, both transgenic and non-transgenic, differed in several respects from the changes observed in other more commonly studied susceptible strains. In A.CA mice, polymorphonuclear cells were a more prominent component of the acute inflammatory infiltrate and in chronic disease, large aggregates of lipid-laden macrophages and cholesterol clefts were present within white matter lesions. The present approach, using genetic manipulation of the immune system, may have relevance to the study of disease mechanisms in other putative autoimmune demyelinating disorders such as multiple sclerosis.
Rapid microfluidic thermal cycler for nucleic acid amplification (2023)

A system for thermal cycling a material to be thermal cycled including a microfluidic heat exchanger; a porous medium in the microfluidic heat exchanger; a microfluidic thermal cycling chamber containing the material to be thermal cycled, the microfluidic thermal cycling chamber operatively connected to the microfluidic heat exchanger; a working fluid at first temperature; a first system for transmitting the working fluid at first temperature to the microfluidic heat exchanger; a working fluid at a second temperature, a second system for transmitting the working fluid at second temperature to the microfluidic heat exchanger; a pump for flowing the working fluid at the first temperature from the first system to the microfluidic heat exchanger and through the porous medium; and flowing the working fluid at the second temperature from the second system to the heat exchanger and through the porous medium.
Two rhenium complexes that contain an unsupported metal-metal double bond in the presence of potentially bridging ligands (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo rhenium complexes that contain an unsupported metal-metal double bond in the presence of potentially bridging ligandsRobert Toreki, Richard R. Schrock, and Michael G. ValeCite this: J. Am. Chem. Soc. 1991, 113, 9, 3610–3611Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/ja00009a068https://doi.org/10.1021/ja00009a068research-articleACS PublicationsRequest reuse permissionsArticle Views320Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Millimeter-wave distance-dependent large-scale propagation measurements and path loss models for outdoor and indoor 5G systems (2016)

This paper presents millimeter-wave propagation measurements for urban micro-cellular and indoor office scenarios at 28 GHz and 73 GHz, and investigates the corresponding path loss using five types of path loss models, the single-frequency floating-intercept (FI) model, single-frequency close-in (CI) free space reference distance model, multi-frequency alpha-beta-gamma (ABG) model, multi-frequency CI model, and multi-frequency CI model with a frequency-weighted path loss exponent (CIF), in both line-of-sight and non-line-of-sight environments. Results show that the CI and CIF models provide good estimation and exhibit stable behavior over frequencies and distances, with a solid physical basis and less computational complexity when compared with the FI and ABG models. Furthermore, path loss in outdoor scenarios shows little dependence on frequency beyond the first meter of free space propagation, whereas path loss tends to increase with frequency in addition to the increased free space path loss in indoor environments. Therefore, the CI model is suitable for outdoor environments over multiple frequencies, while the CIF model is more appropriate for indoor modeling. This work shows that both the CI and CIF models use fewer parameters and offer more convenient closed-form expressions suitable for analysis, without compromising model accuracy when compared to current 3GPP and WINNER path loss models.
Flanging and Hemming of Auto Body Panels using the Electro Magnetic Forming technology (2008)

Electro Magnetic Forming (EMF) technology has a great number of potential applications for the automotive industry. LABEIN-Tecnalia has worked with this technology for six years and has a good understanding of the automotive industry s needs and challenges. LABEIN-Tecnalia is currently developing new applications with EMF technology. Taking into account the advantages and limitations of EMF, bending and hemming processes present good geometric conditions for the use of this technology. The study presented is based largely on hemming circular configurations which are simplifications of those commonly used on hemmed automotive parts. The parameters of this new EMF bending and hemming processes have been studied, as well as their influence on the final quality of the parts obtained. Conclusions obtained from the basic geometries were tested on a more complicated geometry in order to apply the knowledge acquired. Parallel to the experimental work, fully coupled electromechanical software by LS-DYNA has been used to simulate and extend the present hemming results.