gebhart/patrepeval huggingface dataset:
Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients (2019)

Colorectal cancer (CRC) is increasingly appreciated as a heterogeneous disease, with factors such as microsatellite instability (MSI), cancer subsite within the colon versus rectum, and age of diagnosis associated with specific disease course and therapeutic response. Activating oncogenic mutations in KRAS and NRAS are common in CRC, driving tumor progression and influencing efficacy of both cytotoxic and targeted therapies. The RAS mutational spectrum differs substantially between tumors arising from distinct tissues. Structure-function analysis of relatively common somatic RAS mutations in G12, Q61, and other codons is characterized by differing potency and modes of action. Here we show the mutational profile of KRAS, NRAS, and the less common HRAS in 13,336 CRC tumors, comparing the frequency of specific mutations based on age of diagnosis, MSI status, and colon versus rectum subsite. We identify mutation hotspots, and unexpected differences in mutation spectrum, based on these clinical parameters.
Relationship Between Vascular Access Flow and Hemodynamically Significant Stenoses in Arteriovenous Grafts (2003)

Analysis of experimental data and the mathematical model shows that a 20 to 30% and greater decrease in graft flow generally suggests the appearance of hemodynamically significant stenosis as defined by flow criteria. The model suggests that not all 50 to 60% stenoses may be hemodynamically significant or the most flow limiting. The mathematical model also suggests that positive predictive value of access surveillance may be increased for high-flow upper arm grafts by increasing the dynamic K/DOQI threshold from 1000 ml/min to 1200 ml/min.
HyTech - The Hydrogen Technology Laboratory at Savannah River (1995)

SRS recently announced the formation of the Hydrogen Technology Laboratory (HyTech) to work with industry and government in developing technologies based on the site`s four decades of experience with tritium and other forms of H. HyTech will continue to sustain the site`s ongoing role in H technology applications for defense programs. In addition, the laboratory will work with the chemical, transportation, power, medical, and other industries to develop and test related technologies. HyTech, which is located in the Savannah River Technology Center, will make use of its facilities and staff, as well as the infrastructure within the site`s Tritium Facilities. More than 80 SRS scientists, engineers, and technical professionals with backgrounds in chemistry, engineering, materials science, metallurgy, physics, and computer science will work with the laboratory. This paper describes some of HyTech`s current initiatives in the area of H storage, transportation, and energy applications.
Perpendicular magnetic anisotropy in sputter-deposited Fe/MgO interfaces tuned by W buffer and Tb capping layers (2018)

Boron plays an exclusive role in obtaining the well-known perpendicular magnetic anisotropy (PMA) developed in CoFeB/MgO interfaces. We demonstrate PMA in boron-free Fe/MgO interfaces using W buffer and Tb capping layers, extending the variety of materials and stacking structures useful for PMA. The W buffer layer leads to non-crystalline growth of the Fe layer, followed by the (001)-oriented growth of MgO. The PMA energy density obtained with a dead layer correction reaches 0.7 MJ/m3 after post-annealing. X-ray absorption spectra suggest that the Tb layer absorbs the excess oxygen atoms at the Fe/MgO interface. Furthermore, the X-ray magnetic circular dichroism clarifies that the PMA originates from the anisotropic orbital magnetic moment in Fe tuned by the Tb capping layer.
Supplementary Figure Legends 1-7 from Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion Variants (2023)

&lt;p&gt;PDF file - 96K&lt;/p&gt;
Wireless mesh network data communications and reliability analysis for anti-theft application deployment in educational institutions (2019)

Purpose The purpose of this study is to locally develop low-cost wireless mesh networks for reliable data communications to devices that prevent the theft of these devices in learning institutions of South Africa. Design/methodology/approach A network test-bench was developed where millions of packets were transmitted and logged between interconnected nodes to analyze the quality of the network’s service in a harsh indoor building environment. Similar methodologies in “big data” analysis as found in particle physics were adopted to analyze the network’s performance and reliability. Findings The results from statistical analysis reveal the quality of service between multiple asynchronous transmitting nodes in the network and compared with the wireless technology routing protocol to assess coverage in large geographical areas. The mesh network provides stable data communications between nodes with the exception of reliability degradation in some multi-hopping routes. Conclusions are presented to determine whether the underlining mesh network technology will be deployed to protect devices against theft in educational institutions of South Africa. Research limitations/implications The anti-theft application will focus on proprietary firmware development with a reputable tablet manufacturer to render the device inoperable. Data communications of devices to the network will be monitored and controlled from a central management system. The electronics embedding the system-on-chip will be redesigned and developed using the guidelines stipulated by the chip manufacturer. Originality/value Design and development of low-cost wireless mesh networks to protect tablets against theft in institutions of digitized learning. The work presents performance and reliability metrics of a low-power wireless mesh wireless technology developed in a harsh indoor building environment.
39.4L: Late‐News Paper : Vertical Organic Transistors (V‐OFETs) for Truly Flexible AMOLED Displays (2015)

We report on the superior transistor performance of the vertical organic field‐effect transistor (V‐OFET), achieving up to 30x higher on‐currents than for reference horizontal organic thin film transistors (OTFTs) with 30 µm channel length and same organic semiconductor material. Furthermore, V‐OFETs show excellent on/off ratios (&gt;10 6 ), good current saturation, and high operational stability. We describe the integration of V‐OFETs as drive transistors into flexible backplanes. We demonstrate flexible AMOLED display prototypes with 100 PPI resolution and 4 inch diagonal size fabricated on low‐cost plastic substrates. This novel backplane technology based on organic materials shows promise to greatly enhance the flexibility of future AMOLED displays.
Geometry compression for time-varying meshes using coarse and fine levels of quantization and run-length encoding (2008)

Time-varying meshes (TVM) is a new 3-D scene representation which are generated from multiple cameras. It captures highly detailed shape and texture as well as movement of real-world moving objects. Compression is a key technology for supporting TVM applications such as education, interactive broadcasting, and intangible heritage archiving. Previous works focused on compression of 3-D animation that has the same topology throughout the entire sequences. Unfortunately, the topology of TVMs change with time which makes it difficult to compress TVMs. In this paper, we propose a geometry encoder for TVMs. The encoder finds spatial and temporal redundancy by coarse and fine level quantization. Thereafter, vertex information is converted into binary sequences. And then, the binary sequences are encoded using run-length encoding (RLE). Experimental results show that vertices of TVMs which require 96 bits per vertex (bpv) are compressed to 1.9-15.4 bpv while maintaining a small geometric distortion ranging from 0.7 times 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> to 1.3 times 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> % of the maximum error.
Effects of calf intestinal alkaline phosphatase, phosphatase inhibitors, and phosphorylated compounds on the rate of activation of glucocorticoid-receptor complexes (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of calf intestinal alkaline phosphatase, phosphatase inhibitors, and phosphorylated compounds on the rate of activation of glucocorticoid-receptor complexesCarol A. Barnett, Thomas J. Schmidt, and Gerald LitwackCite this: Biochemistry 1980, 19, 23, 5446–5455Publication Date (Print):November 11, 1980Publication History Published online1 May 2002Published inissue 11 November 1980https://pubs.acs.org/doi/10.1021/bi00564a046https://doi.org/10.1021/bi00564a046research-articleACS PublicationsRequest reuse permissionsArticle Views857Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Argument Schemes for Reasoning about Trust (2012)

Trust is a natural mechanism by which an autonomous party can deal with the inherent uncertainty regarding the behaviors of other parties and the uncertainty in the information it shares with those parties. Trust is thus crucial in any decentralized system. We build on recent efforts to use argumentation to reason about trust. Specifically, we provide a set of schemes, abstract patterns of reasoning that apply in multiple situations, geared toward trust. We describe, in the form of a set of critical questions, the situations in which the schemes may default.
Design, implementation and performance evaluation of an MDFE read channel (1998)

A 100 Mb/s (1,7) MDFE (multi-level decision feedback equalization) read channel has been designed, prototyped, and tested on a spinstand. It is made up of an analog forward equalizer consisting of two biquads, a comparator, a feedback equalizer consisting of 6 taps plus an analog exponential decay circuit, timing/gain/dc-offset control circuits, an analog PLL and VCO, and VGA. An analytical technique has been developed for equalizer design. It incorporates certain key constraints for reducing hardware complexity as well as error propagation. The measured bit-error-rate and off-track performance demonstrate the robustness of the equalizer over a broad range of user densities. The experimental results confirm that MDFE is a viable signal detection technique for achieving high density and high data rate magnetic recording.
Adaptive HARQ with Memoryless Relays (2011)

In a relay enhanced system the classical HARQ schemes should be adapted to exploit the better channel conditions of the relay in comparison to the direct link. In particular, we need to decide which node (either the source or one of the relays) should retransmit and how many resources have to be spent to avoid further retransmissions. This adaptation should be optimized with respect to the trade-off between Frame Error Rate (FER) and the required resources. We propose an approach based on accumulated Mutual Information (MI) for relay networks applying different relay functions. We consider several memory less relay functions without channel decoding aiming for simple and cheap relays. Besides the well-known Amplify-Forward (AF) and Detect-Forward (DetF) schemes, we also consider a soft information relaying function called Estimate-Forward (EF) as this provides higher Mutual Information than AF and DetF. We show that our proposed HARQ retransmission scheme can improve the throughput significantly, especially if EF is applied at the relay.
Use of multiple functionalised ligand sets in metalorganic framework formation : synthesis, characterisation and gas uptake studies (2013)

Abstract
A variety of metal-organic frameworks have been synthesised and structurally
characterised and their gas uptake behaviours investigated.
The solvothermal reaction of Zn(NO3)2.6H2O with 5-aminoisophthalic acid (H2-5-
AIP) and 4,4'-bipyridyl (4,4'-bipy) led to the self-assembly of the 3D hybrid Hbonded/
covalent structure {[Zn(5-AIP)(4,4'-bipy)0.5].DMF}n (1), with an analogous
reaction using the related molecule 4,4'-azopyridine (4,4'-azopy) in place of 4,4'-bipy
giving the isostructural framework {[Zn(5-AIP)(4,4'-azopy)0.5].DMF}n (2). Similar
solvothermal reactions of Co(NO3).6H2O, Mn(NO3).4H2O and Cd(NO3).4H2O with
5-aminoisophthalate and the potential linkers 4,4'-bipy, 1,2-di(4-pyridyl)ethylene
(DPE) and 4,4'-azopy afforded the porous 3D structures {[Co2(NO3)2(5-AIP)(4,4'-
bipy)2].2EtOH}n (3), {[Co(5-AIP)(DPE)].3DMF}n (4), {[Co(5-AIP)(4,4'-
azopy)].2DMA}n (5), {[Mn(5-AIP)(4,4'-bipy)].2DMA}n (6), {[Mn(5-
AIP)(DPE)].1.5DMF}n (7), {[Mn(5-AIP)(4,4'-azopy)].1.5DMF}n (8), {[Cd(5-
AIP)(4,4'-bipy)].3DMF}n (9), {[Cd(5-AIP)(DPE)].DMF}n (10) and {[Cd(5-
AIP)(4,4'-azopy)].DMF}n (11), with structures 4-10 bearing the same network
topology. Carbon dioxide uptakes for these structures, whilst modest, reveal an
interesting pattern, with enhanced uptakes observed for those structures which bear
larger pore sizes and polar functionalities.
Hydrothermal reactions of the reduced Schiff base 4-carboxy-phenylenemethyleneamino-
4-benzoic acid (L1H2) with Zn(OH)2 and DPE afforded a nonporous
2D coordination polymer of the formula {[Zn2(L1)2(DPE)].H2O}n, (12) with
the analogous reaction of L1H2 with Zn(OH)2 and 4,4'-azopy giving the porous 3D
structure {[Zn3(L1)3(4,4'-azopy)].7.5H2O}n (13), which exhibits interesting hysteretic
behaviour on CO2 adsorption and desorption.
Lower-rim acid functionalised calix[4]arene structures (14, 15) were prepared by the
reaction of 25,27-bis(methoxycarboxylic acid)-26,28-dihydroxycalix[4]arene (L2H2)
coordination polymers with Li2CO3 and tert-butyllithium respectively, with the
solvothermal reaction of L2H2 with zinc nitrate affording the 1D coordination
polymer of {[Zn(L2)2](DMF)(H2O)}n (16). Solvothermal reactions of the related
calix[4]arene molecule 25,27-bis(methoxycarboxylic acid)-26,28-dihydroxy-4-
tertbutylcalix[4]arene (L3H2) with Zn(NO3)2.6H2O and 4,4'-bipy, DPE and 4,4'-
ii
azopy gave a series of 2D structures of the formulae {[Zn(4,4'-bipy)(L3)].2.25DEF}n
(17), {[Zn2(L3)(DPE)].DEF}n (18) and {[Zn(OH2)2(L3)(4,4'-azopy)].DEF}n (19).
The structures have been fully characterised and their porosities investigated using
TGA.
Chemical demonstration of nuclear androgen receptor following affinity chromatography with immobilized ligands (1987)

With increasing purification of the androgen receptor from nuclei of rat ventral prostate, a receptor-like protein could be demonstrated by chemical staining with silver nitrate. After sonication and digestion of nuclei with micrococcal nuclease, the solubilized receptor was applied to a column of Matrex Gel Green A and eluted with a linear gradient of 0-2 M NaCl. Characterized by specific binding of dihydrotestosterone, this form of the receptor was also androgen dependent and yielded an apparent Mr of 33,000 when analyzed by polyacrylamide gel electrophoresis and silver nitrate staining. To facilitate recovery following chromatography, the receptor was precipitated with 0-40% ammonium sulfate. Analysis of the 15-fold enriched fraction by sucrose density-gradient centrifugation confirmed the presence of a 3S androgen-binding protein. About 200 ng of the precipitated protein was applied to a column of dihydrotestosterone-17 beta-succinyl agarose (ligand concentration, 0.25 mumol/ml). The fractions eluted with 50 microM dihydrotestosterone were electrophoresed and stained as before; again, the presence of a 33,000 Mr protein sensitive to castration was demonstrated. Alternatively, when the precipitated protein was fractionated by fast protein liquid chromatography utilizing a Superose 12 HR 10/30 column, the receptor coeluted with nuclear proteins in the 29,000-36,000 Mr range as determined both by retention time and electrophoresis. In combination, the above methods may be used to obtain a receptor protein purified to near homogeneity with a yield of 5-10%. The amount of receptor afforded by the purification sequence is small but nevertheless sufficient for chemical detection. We anticipate that with modification, the procedures may prove suitable for the recovery of nuclear androgen receptor on a preparative scale.
Microfabrication of magnetostrictive beams based on NiFe film doped with B and Mo for integrated sensor systems (2012)

This paper reports the development of integrated micro-sensors consisting of 1 -µm-thick magnetostrictive cantilevers or bridges with 500 µm in length and conducting interrogation elements. The thin films are fabricated by sputter deposition of NiFe doped with B and Mo, and the magnetic properties are enhanced by field annealing, resulting in a coercivity of 2.4 Oe. In operation, an alternating current applied to the interrogation elements magnetizes the magnetostrictive structures. The longitudinal resonant frequency is detected as an impedance change of the interrogation elements. The magnetostrictive micro-beams provide high resonant frequencies—2.95 MHz for the cantilever and 5.46 MHz for the bridge—which can be exploited to develop sensors of high sensitivity.
EXTERNAL CAROTID ARTERY TO MIDDLE CEREBRAL ARTERY BYPASS WITH THE SAPHENOUS VEIN GRAFT (2008)

Patients with occlusive cerebrovascular disease who have failed maximal medical therapy, which consists of antiplatelet agents as well as maximizing modifiable risk factors such as blood pressure, cholesterol, smoking cessation, and obesity, and whose lesions are not amenable or have not responded to the more common vascular procedures (i.e., carotid endarterectomy or stenting) are considered candidates for an extracranial-intracranial bypass. Additionally, for a patient to be a candidate, he/she must have an adequate graft vessel. Typically, this vessel is the superficial temporal artery. However, oftentimes, the superficial temporal artery is an inadequate vessel or the patient requires a high-flow conduit. It is in these patients that use of the saphenous vein should be considered. In this report, we detail the technical aspects of performing an extracranial-intracranial bypass by using a saphenous vein graft.
ESCWGA/NASPE/P Experts Consensus Statement: (1999)

Current nomenclature for the AV junctions derives from a surgically distorted view, placing the valvar rings and the triangle of Koch in a single plane with anteroposterior and right-left lateral coordinates. Within this convention, the aorta is considered to occupy an anterior position, whereas the mouth of the coronary sinus is shown as being posterior. Although this nomenclature has served its purpose for the description and treatment of arrhythmias dependent on accessory pathways and AV nodal reentry, it is less than satisfactory for the description of atrial and ventricular mapping. To correct these deficiencies, a consensus document has been prepared by experts from the Working Group of Arrhythmias of the European Society of Cardiology and from the North American Society of Pacing and Electrophysiology. It proposes a new, anatomically sound, nomenclature that will be applicable to all chambers of the heart. In this report, we discuss its value for description of the AV junctions and establish the principles of this new nomenclature.
The Impact of Traumatic Brain Injury on Later Life: Effects on Normal Aging and Neurodegenerative Diseases (2017)

The acute and chronic effects of traumatic brain injury (TBI) have been widely described; however, there is limited knowledge on how a TBI sustained during early adulthood or mid-adulthood will influence aging. Epidemiological studies have explored whether TBI poses a risk for dementia and other neurodegenerative diseases associated with aging. We will discuss the influence of TBI and resulting medical comorbidities such as endocrine, sleep, and inflammatory disturbances on age-related gray and white matter changes and cognitive decline. Post mortem studies examining amyloid, tau, and other proteins will be discussed within the context of neurodegenerative diseases and chronic traumatic encephalopathy. The data support the suggestion that pathological changes triggered by an earlier TBI will have an influence on normal aging processes and will interact with neurodegenerative disease processes rather than the development of a specific disease, such as Alzheimer's or Parkinson's. Chronic neurophysiologic change after TBI may have detrimental effects on neurodegenerative disease.
Factorization-based Lossless Compression of Inverted Indices (2011)

Many large-scale Web applications that require ranked top-k retrieval such as Web search and online advertising are implemented using inverted indices. An inverted index represents a sparse term-document matrix, where non-zero elements indicate the strength of term-document association. In this work, we present an approach for lossless compression of inverted indices. Our approach maps terms in a document corpus to a new term space in order to reduce the number of non-zero elements in the term-document matrix, resulting in a more compact inverted index. We formulate the problem of selecting a new term space that minimizes the resulting index size as a matrix factorization problem, and prove that finding the optimal factorization is an NP-hard problem. We develop a greedy algorithm for finding an approximate solution. A side effect of our approach is increasing the number of terms in the index, which may negatively affect query evaluation performance. To eliminate such effect, we develop a methodology for modifying query evaluation algorithms by exploiting specific properties of our compression approach. Our experimental evaluation demonstrates that our approach achieves an index size reduction of 20%, while maintaining the same query response times. Higher compression ratios up to 35% are achievable, however at the cost of slightly longer query response times. Furthermore, combining our approach with other lossless compression techniques, namely variable-byte encoding, leads to index size reduction of up to 50%.
Word‐serial Architectures for Filtering and Variable Rate Decimation (2001)

A new flexible architecture is proposed for word‐serial filtering and variable rate decimation/interpolation. The architecture is targeted for low power applications requiring medium to low data rate and is ideally suited for implementation on either an ASIC or an FPGA. It combines the small size and low power of an ASIC with the programmability and flexibility of a DSP. An efficient memory addressing scheme eliminates the need for power hungry shift registers and allows full reconfiguration. The decimation ratio, filter length and filter coefficients can all be changed in real time. The architecture takes advantage of coefficient symmetries in linear phase filters and in polyphase components.