gebhart/patrepeval huggingface dataset:
Dramatic response of a metastatic carcinoid tumour to a combination of interferon and octreotide (1992)

The combination of alpha-interferon and octreotide has rarely been tested in the treatment of carcinoid syndrome. We describe a patient who was moribund when treated with interferon alone, but enjoyed a dramatic response leading to disappearance of all symptoms, normalization of dU-5-HIAA, and restoration of his normal life-style when octreotide was initiated. Neither interferon nor octreotide could be withdrawn without reappearance of the symptoms, suggesting that the combination of alpha-interferon and octreotide may have synergistic effects in carcinoid syndrome.
Determination of Testis Temperature Rhythms and Effects of Constant Light on Testicular Function in the Domestic Fowl (Gallus domesticus)1 (1997)

There is a wide range of opinions regarding the operating temperature of the testis in the domestic fowl. We used physiological monitoring techniques to investigate testis and body temperature over daily periods and under various light regimes to elucidate body temperature gradients in the fowl. We confirm that the operating temperature of the adult fowl's testes is equivalent to core body temperature (40-41 degrees C). Long-term continuous temperature monitoring showed that there was no difference between the temperature of the testis, liver, and peritoneum during a 24-h period either in a normal light:dark cycle or under constant light conditions. However, there was a slight decrease in all temperatures at subjective night in each case, a decrease that does not appear to be sufficient to influence spermatogenesis. Birds maintained under constant light throughout two cycles of the seminiferous epithelium (28 days) still exhibited normal testis function and structure, even when "nightly" testis temperature decrease was the lowest. Thus, by undergoing spermatogenesis at an elevated temperature, the domestic fowl system is unique among the homeothermic animal systems studied to date.
Monochrome hybrid, multilevel, halftone screen with unequal spatial resolution for a low-cost electrophotographic printer (2018)

The hybrid screen leverages two halftoning techniques, screening and direct binary search (DBS), to achieve the better quality of the halftoned images, and to enable the algorithm to be integrated into low-cost printers with limited computational resources. This work proposes a complete hybrid screen design method for multilevel output with unequal resolution printing pixels in a laser electrophotographic system. Because of the unstable rendering output of the electrophotographic process, we adopt a clustered- dot screen in our work. We also use the supercell approach to solve the trade-off between screen frequency and the effective number of quantization levels that is inherent to a cluster-dot screen. Moreover, we use subpixel modeling to simulate the unequal resolution printing pixels and multilevel output. This method is well-suited to development of halftoning algorithms for systems with unequal resolution. We also explore several design rules to evaluate the impact on printing quality.
Drug release and bone growth studies of antimicrobial peptide‐loaded calcium phosphate coating on titanium (2012)

Preventing infection is one of the major challenges in total hip and joint arthroplasty. The main concerns of local drug delivery as a solution have been the evolution of antibiotic-resistant bacteria and the potential inhibition of osseointegration caused by the delivery systems. This work investigated the in vitro drug release, antimicrobial performance, and cytotoxicity, as well as the in vivo bone growth of an antimicrobial peptide loaded into calcium phosphate coated Ti implants in a rabbit model. Two potent AMP candidates (HHC36: KRWWKWWRR, Tet213: KRWWKWWRRC) were first investigated through an in vitro cytotoxicity assay. MTT absorbance values revealed that HHC36 showed much lower cytotoxicity (minimal cytotoxic concentration 200 μg/mL) than Tet 213 (50 μg/mL). The AMP HHC36 loaded onto CaP (34.7 ± 4.2 μg/cm(2)) had a burst release during the first few hours followed by a slow and steady release for 7 days as measured spectrophotometrically. The CaP-AMP coatings were antimicrobial against Staphylococcus aureus and Pseudomonas aeruginosa strains in colony-forming units (CFU) in vitro assays. No cytotoxicity was observed on CaP-AMP samples against MG-63 osteoblast-like cells after 5 days in vitro. In a trabecular bone growth in vivo study using cylindrical implants, loading of AMP HHC36 did not impair bone growth onto the implants. Significant bone on-growth was observed on CaP-coated Ti with or without HHC36 loading, as compared with Ti alone. The current AMP-CaP coating thus offers in vivo osteoconductivity to orthopedic implants. It also offers in vitro antimicrobial property, with its in vivo performance to be confirmed in future animal infection models.
Liquid Prepolymer-Based in Situ Formation of Degradable Poly(ethylene glycol)-Linked-Poly(caprolactone)-Linked-Poly(2-dimethylaminoethyl)methacrylate Amphiphilic Conetwork Gels Showing Polarity Driven Gelation and Bioadhesion (2018)

Amphiphilic conetwork (APCN) gels suffer from lack of direct injectability due to use of organic solvent, prolonged crosslinking/polymerization process and immiscibility between hydrophilic and hydrophobic prepolymers. On the basis of prepolymers compatibility and polarity, we report the use of an advanced prepolymer liquid system for in situ construction of APCN gels. Solid elastic poly(ethylene glycol)-<i>linked</i>-poly(ε-caprolactone)-<i>linked</i>-poly(2-dimethylaminoethyl)methacrylate (PEG-<i>l</i>-PCL-<i>l</i>-PDMA) APCN gels were formed upon addition of an appropriate amount of PDMA diluted in nonreactive sacrificial liquid PEG into a compatible blend of activated halide terminated PEG and PCL liquids. Compatibility among the prepolymers allowed favorable gelation. The polarity of the prepolymer liquid greatly influenced the gelation time. PEG-<i>l</i>-PCL-<i>l</i>-PDMA APCN gels were cytocompatible/biodegradable and showed storage modulus in the range of 50-200 kPa and bioadhesive strength of 40-90 kPa. The fluorescence experiments showed that the hydrophobic probe, pyrene was distributed in both hydrophilic and hydrophobic phases of the APCN gels. These APCNs exhibited sustained release of hydrophobic and hydrophilic drugs. Effects of polarity, composition, and molecular weight of the liquid prepolymers on the gelation time, rheological property, and swelling behavior of the APCN gels have been investigated in details.
Investigation of the subunit structure of yeast enolase (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigation of the subunit structure of yeast enolaseJohn M. Brewer, T. Fairwell, J. Travis, and R. E. LovinsCite this: Biochemistry 1970, 9, 4, 1011–1016Publication Date (Print):February 1, 1970Publication History Published online1 May 2002Published inissue 1 February 1970https://pubs.acs.org/doi/10.1021/bi00806a041https://doi.org/10.1021/bi00806a041research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Local brassinosteroid biosynthesis enables optimal root growth (2020)

Abstract Brassinosteroid hormones are indispensable for root growth and they control both cell division and cell elongation through the establishment of an increasing signaling gradient along the longitudinal root axis. Because of their limited mobility, the importance of brassinosteroid distribution for achieving the signaling maximum is largely overlooked. Expression pattern analysis of all known brassinosteroid biosynthetic enzymes revealed that not all cells in the Arabidopsis thaliana root possess full biosynthetic machinery and completion of biosynthesis relies on cell-to-cell movement of the hormone precursors. We demonstrate that brassinosteroid biosynthesis is largely restricted to the root elongation zone where it overlaps with brassinosteroid signaling maxima. Moreover, optimal root growth requires hormone concentrations, low in the meristem and high in the root elongation zone attributable to an increased biosynthesis. Our finding that spatiotemporal regulation of hormone synthesis results in a local hormone accumulation provides a paradigm for hormone-driven organ growth in the absence of long-distance hormone transport in plants.
UHF white space in Europe &#x2014; A quantitative study into the potential of the 470&#x2013;790 MHz band (2011)

In this paper we study the availability of TV white spaces in Europe. We focus specifically on the 470–790 MHz UHF band that is still predominantly used for TV broadcasting also after the digital dividend (frequency reallocation as part of transition to digital TV), which has taken place or is ongoing in several European countries. We find that in the countries used in our studies, approximately 56% of the TV channels are unused, when averaged over the whole geographic area. Considering the average over population instead of geographic area reduced the mean available white space to 49% of the channels. Our results confirm quantitatively the often stated expectation that there are indeed fewer white spaces available in Europe compared to, for example, the United States. We also study the influence of different modeling assumptions on our results, especially focusing on the impact of the choice of propagation model. Our results show that changing from statistical ITU-R model to the Longley-Rice irregular terrain model does not cause a major change in the overall estimated availability of white spaces. However, changing the propagation model can significantly affect especially the local variability of the estimated availability of spectrum. This underlines the importance of using right system models in various studies before making too far-reaching conclusions.
Ability of Foot-and-Mouth Disease Virus To Form Plaques in Cell Culture Is Associated with Suppression of Alpha/Beta Interferon (1999)

A genetic variant of foot-and-mouth disease virus lacking the leader proteinase coding region (A12-LLV2) is attenuated in both cattle and swine and, in contrast to wild-type virus (A12-IC), does not spread from the initial site of infection after aerosol exposure of bovines. We have identified secondary cells from susceptible animals, i.e., bovine, ovine, and porcine animals, in which infection with A12-LLV2, in contrast to A12-IC infection, does not produce plaques; this result indicates that this virus cannot spread from the site of initial infection to neighboring cells. Nevertheless, A12-LLV2 can infect these cells, but cytopathic effects and virus yields are significantly reduced compared to those seen with A12-IC infection. Reverse transcription-PCR analysis demonstrates that both A12-LLV2 and A12-IC induce the production of alpha/beta interferon (IFN-alpha/beta) mRNA in host cells. However, only supernatants from A12-LLV2-infected cells have significant antiviral activity. The antiviral activity in supernatants from A12-LLV2-infected embryonic bovine kidney cells is IFN-alpha/beta specific, as assayed with mouse embryonic fibroblast cells with or without IFN-alpha/beta receptors. The results obtained with cell cultures demonstrate that the ability of A12-IC to form plaques is associated with the suppression of IFN-alpha/beta expression and suggest a role for this host factor in the inability of A12-LLV2 to spread and cause disease in susceptible animals.
Correlation of T1ρ with fixed charge density in cartilage (2004)

The strong correlation of the FCD and T1rho data in both the controlled and physiological models demonstrates that changes in T1rho are due predominantly to changes in PG content. This work is a first step in establishing T1rho as a method of quantifying PG changes in early-stage OA.
Impact of ambient atmosphere on plasma-damaged porous low-k characterization (2011)

Improving Integrated Circuits performance requires the use of porous SiCOH in interconnects. However, porosity leads to plasma species diffusion into the material during the patterning steps, which damages the low-k properties. Characterizing plasma-damaged porous SiCOH is not straightforward, and requires a specific characterization setup and protocol. In this paper, we show the impact of the ambient atmosphere on the low-k properties, and how it should be taken into account during the characterization of plasma-damaged porous SiCOH.
A neurosurgical approach to far-lateral disc herniation (1990)

A technique for exposing far-lateral intervertebral disc herniations without disrupting the facet is described. This technique is a simple modification of the standard neurosurgical approach.
Propagation delays and transition times in pulse-modulated semiconductor lasers (1986)

An experimental and theoretical study of large-signal switching transients in directly modulated semiconductor lasers shows that the main parameters affecting high-speed switching are the small-signal relaxation oscillation frequency and the optical on/off ratio of the pulses. Simple expressions agree well with measured data and can be used to obtain an estimate of the maximum achievable modulation bit rate.
HIF hydroxylation and cellular oxygen sensing (2004)

Hypoxia-inducible factor (HIF) is a transcriptional complex that mediates a broad range of cellular and systemic responses to hypoxia. Analysis of HIF-alpha subunits has demonstrated that its activity is regulated by a series of oxygen-dependent enzymatic hydroxylations at specific prolyl and asparaginyl residues. Combined structural/genetic approaches have identified the relevant enzymes as members of the 2-oxoglutarate-dependent dioxygenase superfamily, possessing a beta-barrel 'jelly-roll' conformation that aligns a 2-histidine/1-carboxylate iron co-ordination motif at the catalytic centre. HIF prolyl hydroxylation is performed by a closely related set of isoenzymes (PHD1-3) that differ in abundance and subcellular localisation. Hydroxylation of either human HIF-1alpha Pro402 or Pro564 promotes interaction with the von Hippel-Lindau tumour suppressor protein (pVHL). In oxygenated cells this process targets HIF-alpha for rapid proteasomal destruction. HIF asparaginyl hydroxylation is performed by a protein termed factor inhibiting HIF (FIH). In oxygenated cells hydroxylation of human HIF-1alpha Asn803 prevents interaction with the p300 transcriptional co-activator, providing a second mechanism by which HIF-mediated transcription is inactivated. Genetic studies demonstrate a critical function for both types of enzyme in regulating the HIF transcriptional cascade. Limitation of activity in hypoxia supports a central role of these hydroxylases in cellular oxygen sensing. Regulation of the amount of hydroxylase protein, and the supply of other co-substrates and co-factors, particularly the cellular availability of iron, also contribute to tuning the physiological response to hypoxia.
Immunotherapy on Trial for New-Onset Type 1 Diabetes (2008)

Type 1 diabetes mellitus is an autoimmune disease in which pathologic, autoreactive T cells of the immune system attack the insulin-secreting pancreatic islets of Langerhans. Cytotoxic T cells, which bear the CD8 protein on their membrane, kill islets, thereby leading to lifelong dependence on insulin for affected patients. Over time, poorly controlled blood glucose levels inevitably result in early illness and early death.1 Invasive blood glucose monitoring, insulin administration, and medical complications of treatment can also themselves cause illness, despite decreased glycemia.Immunosuppressive agents, one of the mainstays of approved treatments for transplantation, have been explored as therapy for patients . . .
Influence of Flickering Light on the Retinal Vessels in Diabetic Patients (2008)

We read with interest the article by Mandecka et al. (1) describing reduced retinal vessel reactivity, as measured by the response to flicker light, in people with diabetes and diabetic retinopathy. Findings from this study provide further insights into the early retinal vessel diameter changes involved in the pathogenesis of diabetic microvascular complications.

Previous population-based studies have …
ChemInform Abstract: Design and Synthesis of Constrained Epothilone Analogues: The Efficient Synthesis of Eleven‐Membered Rings by Olefin Metathesis. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Plastic Deformation of Semicrystalline Polyethylene by X-ray Scattering: Comparison with Atomistic Simulations (2013)

Plastic deformation of uniaxially oriented polyethylene (PE) fiber has been examined by small and wide angle synchrotron X-ray scattering. Morphology changes of the lamellar stack with deformation beyond yielding have been characterized and quantified. Atomistic simulations of tensile deformation of the lamellar stack in the longitudinal direction compare favorably to the experimentally observed morphological changes in the PE fiber. Experimental deformations at 100 °C exhibit responses comparable to those observed by simulation of deformation with constant total volume at 77 °C and a strain rate of 5 × 106 s–1. Experimental deformations of the PE fiber at 25 °C were found to be comparable to simulated tensile deformation with constant lateral dimensions at 77 °C and a strain rate of 5 × 107 s–1. Cavitation in the interlamellar region was found experimentally in the PE fiber deforming at room temperature as predicted by simulation with constant lateral dimensions at the higher strain rate. Melting, recrystallization, and removal of entanglements observed in the PE fiber deformation at 100 °C agree with the simulation results of a constant volume deformation at the slower strain rate. The ability to define the deformation behavior of PE at room and at high temperatures through simulation offers unique opportunities to examine how the interlamellar amorphous topology affects PE deformation.
Blind ISI cancellation by anchoring an arbitrary impulse response coefficient of channels (2000)

An algorithm for blind ISI cancellation in multi-user systems is developed in this paper. By minimizing the distance between the output of a filter and a reference signal with different time delay for two filters, the output of one filter turns out to be exactly equal to the ISI component of the output of the other filter. The difference between the output of these filters is the ISI-free estimate of the signal. With an appropriate selection of the time delay introduced for the reference signal, any coefficient of the channel impulse response which determines the scale of ISI-free estimate, can be anchored accordingly. Computer simulation has been conducted to illustrate the performance of this new method.
A simple approach to sense codon-templated synthesis of natural/unnatural hybrid peptides (2005)

In the presence of Phe-SA, the stable sulfamoyl analogue of phenylalanyl adenylate, the codon (UUU/UUC) for phenylalanine (Phe) can be reassigned to naphthylalanine (Nap) bound to tRNA(Phe). The efficiency and selectivity of this Phe-to-Nap reassignment induced by the "orthogonal reacylation stalling" method was demonstrated at the single-codon level in the translation of mRNAs of dihydrofolate reductase (DHFR) and a 24-mer oligopeptide. In the prokaryotic translation system with essential preincubation, the endogenous precharged phenylalanyl-tRNA(Phe) undergoes deacylation and reacylation of the resulting tRNA(Phe) is inhibited by the action of Phe-SA to kill the phenylalanyl-tRNA synthetase activity. The significance of the present small-molecule-based approach to sense-codon templated natural-unnatural peptides is discussed.
A Formalization of Safely Composable Web Components. (2020)

This is the final version. Available from AFP via the link in this record
Measuring Cerebral Activation From fNIRS Signals: An Approach Based on Compressive Sensing and Taylor–Fourier Model (2016)

Functional near-infrared spectroscopy (fNIRS) is a noninvasive and portable neuroimaging technique that uses NIR light to monitor cerebral activity by the so-called haemodynamic responses (HRs). The measurement is challenging because of the presence of severe physiological noise, such as respiratory and vasomotor waves. In this paper, a novel technique for fNIRS signal denoising and HR estimation is described. The method relies on a joint application of compressed sensing theory principles and Taylor-Fourier modeling of nonstationary spectral components. It operates in the frequency domain and models physiological noise as a linear combination of sinusoidal tones, characterized in terms of frequency, amplitude, and initial phase. Algorithm performance is assessed over both synthetic and experimental data sets, and compared with that of two reference techniques from fNIRS literature.
Alterations in Actin‐Binding β‐Thymosin Expression Accompany Neuronal Differentiation and Migration in Rat Cerebellum (1993)

The beta 4- and beta 10-thymosins, recently identified as actin monomer-sequestering proteins, are developmentally regulated in brain. Using specific mRNA and protein probes, we have used in situ hybridization and immunohistochemical techniques to investigate the distribution of the beta-thymosin mRNAs and their proteins in developing rat cerebellum. Early in postnatal development, both beta-thymosin mRNAs were expressed at highest levels in the postmitotic, premigratory granule cells of the external granular layer; expression diminished as granule cells migrated to and differentiated within the developing internal granular layer. In addition, both beta-thymosin proteins were present in bundles of cerebellar afferent fibers in the white matter at this time. Throughout the maturation period, both proteins were present in elongating parallel fibers in the upper portion of the molecular layer. Later in cerebellar development, thymosin beta 4, but not thymosin beta 10, was expressed in Golgi epithelial cells and Bergmann processes. Thymosin beta 4 was expressed in a small population of cells with microglial morphology scattered throughout the gray and white matter. Thymosin beta 10 was detected in an even smaller population of glia. Expression of thymosin beta 4 and thymosin beta 10 in premigratory granule cells and in growing neuronal processes is consistent with the possibility that both beta-thymosins are involved in the dynamics of actin polymerization during migration and process extension of neurons.