gebhart/patrepeval huggingface dataset:
Investigation of Carbon Materials as Supports for Metalloporphyrins Used for Cathode Catalyst in Fuel Cells (2006)

酸素四電子還元触媒として有効なコバルトポルフィリンとして, 5,10,15,20-テトラエチルポルフィリンコバルト (CoTEtP) を合成した. 比表面積の異なる各種炭素粒子 (カーボンブラック) および多層カーボンナノチューブ (MWCNT) 表面上にCoTEtPを修飾し, 調製した触媒をNafion溶液に分散させ, エッジ面パイロリティックグラファイト (EPG) 電極上にキャストすることにより修飾電極とした. X線光電子分光法 (XPS) により, CoTEtPを担持させたカーボンブラックの触媒表面のCo濃度 (Co atom%) をもとめた結果, 比表面積の大きな担体ほど触媒表面のCo濃度が増加する傾向が示された. サイクリックボルタンメトリー (CV) および回転ディスク電極 (RDE) を用いた電気化学的測定により, 熱処理前の触媒においては, 比表面積が大きなBlack Pearls 2000を担体として用いた触媒でピーク電位は最も貴なEp=0.48V vs. SCEとなり, CoTEtPの吸着量に伴い活性が向上することが明らかとなった. 得られた触媒を不活性ガス雰囲気下で熱処理するとさらなる活性向上が認められ, Ketjen Black ECを担体として用いた触媒においても貴な電位 (Ep=0.51V vs. SCE) および高い反応選択度 (反応電子数n =3.9) で酸素の四電子還元が進行することが明らかとなった. CoTEtPをMWCNTへ担持させる際には, 界面活性剤であるTriton X-100を添加し分散性向上を試みた. Triton X-100を加えた系では触媒表面のCo濃度の増大が観測されたが, 触媒表面へのTriton X-100の吸着のためにRDE測定から求めた活性化支配電流であるIkの値は, Triton X-100を添加していない触媒と比べて減少した. MWCNTを担体として用いた触媒を熱処理すると, カーボンブラックと同様に活性向上を示した. 特にTriton X-100を添加した触媒では, MWCNTに吸着していたTriton X-100が熱処理により分解し, 電荷移動が容易になったため, Ikの値が大幅に増大した. 本実験系で調製したこれらの触媒において, 燃料電池における白金によらない新しいカソード触媒としての可能性が示された.
Constitutive Model of Radiation Aging Effects in Filled Silicone Elastomers under Strain (2021)

Filled silicone elastomers, an essential component in many technological applications, are often subjected to controlled or unintended radiation for a variety of reasons. Radiation exposure can lead to permanent mechanical and structural changes in the material, which is manifested as altered mechanical response, and in some cases, a permanent set. For unfilled elastomers, network theories developed and refined over decades can explain these effects in terms of chain-scission and cross-link formation and a hypothesis involving independent networks formed at different strain levels of the material. Here, we expose a filled silicone rubber to gamma radiation while being under finite elongational strain and show that the observed mechanical and structural changes can be quantitatively modeled within the same theoretical framework developed for unfilled elastomers as long as nuances associated with the Mullins effect are accounted for in a consistent manner. In this work, we employ Ogden's incompressible hyperelastic model within the framework of Tobolsky's two-network scheme to describe the observed permanent set and mechanical modulus changes as a function of radiation dosage. In the process, we conclude that gamma radiation induces both direct cross-linking at chain crossings (H-links) and main-chain-scission followed by cross-linking (Y-links). We provide an estimate of the ratio of chain-scission to cross-linking rates, which is in reasonable agreement with previous experimental estimate from Charlesby-Pinner analysis. We use density functional theory (DFT)-based quantum mechanical calculations to explore the stability of -Si and -SiO radicals that form upon a radiation-induced chain-scission event, which sheds light on the relative rates of Y-linking and H-linking processes.
Double conversion method for synthesis of inverse filters (2015)

A novel method for the inverse filter synthesis of the same type from an original filter is presented. The proposed procedure utilizes a double conversion, frequency inversion and swapping the transfer and reflection functions, which are commonly used for lowpass to highpass filter transformation. Due to the use of double conversions, the resulting filter always has the same type as the original filter. Using this procedure, the available general Chebyshev synthesis method can be used to synthesize inverse Chebyshev and elliptic filters. As an illustration, the coupling matrix of a third-order inverse Chebyshev bandpass filter is synthesized using the presented method. Then the original filter and its inverse filter are fabricated using microstrip technology. The measured and simulated filter results are shown to be in good agreement.
A step-superposition based analysis approach to modeling resonant converters (2015)

This paper introduces a new analysis approach to modeling resonant converters that can be used to determine closed-form expressions for the exact resonant network waveforms. This approach, based on superposition of step responses to inverter and rectifier imposed steps, does not require analysis of the different operating modes of a resonant converter, and can easily be applied to resonant converters with high-order resonant networks, multiple inverters and/or rectifiers. The usefulness of the proposed analysis approach is demonstrated by applying it to a series resonant converter and the recently-proposed impedance control network (ICN) resonant converter. The modeling results are validated using a 200 W, 500 kHz ICN resonant converter. It is shown that there is an excellent agreement between the experimental and modeled waveforms during steady-state operation and during startup.
Characterization of modems and error correcting protocols using a scintillation playback system (2016)

The performance of free space optical (FSO) communication systems is strongly affected by optical scintillation. Scintillation fades can cause errors when the power on a detector falls below its noise floor, while surges can overload a detector. The very long time scale of scintillation compared to a typical bit in an FSO link means that error-correcting protocols designed for fiber optic links are inappropriate for FSO links. Comparing the performance effects of different components, such as photodetectors, or protocols, such as forward error correction, in the field is difficult because conditions are constantly changing. On the other hand, laboratory-based turbulence simulators, often using hot plates and fans, do not really simulate the effects of long-range propagation through the atmosphere. We have investigated a different approach. Scintillation has been measured during field tests using FSO terminals by sending a continuous wave beam through the atmosphere. A high dynamic range photodetector was digitized at a 10 KHz rate and files of the intensity variations were saved. Many hours of scintillation data under different environmental conditions and at different sites have been combined into a library of data. A fiber-optic based scintillation playback system was then used in the laboratory to test modems and protocols with the recorded files. This allowed comparisons using the same atmospheric conditions allowing optimization of such parameters as detector dynamic range. It also allowed comparison and optimization of different error correcting protocols.
Supplementary Figure 3 from Therapeutic and Prophylactic Antitumor Activity of an Oral Inhibitor of Fucosylation in Spontaneous Mammary Cancers (2023)

&lt;p&gt;Shown is the effect of 2FF treatment on (A) Amount of IgG (Mean {plus minus} SEM) isolated from 75uL of sera collected, and (B) AAL lectin-based measurement of fucosylation (Mean {plus minus} SEM) of these samples from untreated (circle) or 2FF-treated (square) TgMMTV-neu mice (n=5 each).&lt;/p&gt;
Case Report: Sustained complete remission on combination therapy with olaparib and pembrolizumab in BRCA2-mutated and PD-L1-positive metastatic cholangiocarcinoma after platinum derivate (2022)

The presented case showed substantial clinical activity of a combination with olaparib/pembrolizumab in advanced BRCA2-mutated CCA. Thus, identifying targetable molecular signatures and combinations of targeted therapies with immunotherapy reveals a promising strategy to effectively treat patients with cholangiocarcinoma and should be considered after failure of standard chemotherapy.
Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets (2011)

Zoonotic infections with swine influenza viruses have occurred sporadically in the past. However, sustained human-to-human transmission of a swine virus did not occur until the emergence of the 2009 pandemic H1N1 (H1N1pdm) virus. H1N1pdm possesses a unique gene combination with gene segments derived from the North America triple reassortant (PB2, PB1, PA, HA, NP, and NS) and the Eurasian avian-like (NA and M) swine influenza viruses.

To identify molecular determinants that enable sustained human-to-human transmission, we compared the direct contact and aerosol transmission efficiency of the pandemic viruses with related swine influenza viruses in ferrets. The transmission potential of seasonal H3N2 [A/Wuhan/359/95 (Wuhan95)], H1N1pdm [A/California/4/09 (CA04) and A/HK/415742/09 ({type:entrez-nucleotide,attrs:{text:HK415742,term_id:915138919,term_text:HK415742}}HK415742)], and genetically related swine influenza viruses [A/sw/HK/4167/99 (H1N1) (swHK4167), A/sw/Arkansas/2976/ 02 (H1N2) (swAR2976), A/sw/HK/915/04 (H1N2) (swHK915) and A/sw/HK/201/ 10 (H1N1) (swHK201)] were studied. Ferrets were inoculated with 105 TCID50 of the virus. Naive direct contact and aerosol contact ferrets were introduced at 1day post-inoculation (dpi). Transmission was defined by detection of virus from nasal washes and/ or seroconversion.

We observed direct contact transmission from inoculated donor ferrets to their cage-mates was observed for all viruses studied, albeit at different efficiency. Classical swine-like swHK4167 showed least efficient contact transmission as virus could be detected from all (3/3) direct contacts only at 6 dpi while viral shedding was detected at 4 dpi in other direct contact groups. Aerosol transmission was detected with human seasonal influenza virus Wuhan95 (2/3), H1N1pdm influenza virus CA04 (3/3), {type:entrez-nucleotide,attrs:{text:HK415742,term_id:915138919,term_text:HK415742}}HK415742 (2/3), and swine precursor virus swHK915 (1/3). Transmission of Wuhan95 or CA04 to aerosol contacts was detected at 4 or 6 dpi, while transmission of swHK915 was detected later at 8 dpi. While the swine influenza viruses studied were able to transmit via the direct contact route, only swHK915 which shares a common genetic derivation for 7 genes with H1N1pdm possessed capacity for aerosol transmission, albeit of moderate efficiency. SwHK915 differed from swine triple reassortant viruses in the origins of its M gene. It is possible that the M gene derived from Eurasian avian-like swine viruses contributes to the aerosol transmissibility of H1N1pdm influenza viruses.
Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3 (2010)

We investigated possible cellular receptors for the human CXC chemokine platelet factor-4 variant/CXCL4L1, a potent inhibitor of angiogenesis. We found that CXCL4L1 has lower affinity for heparin and chondroitin sulfate-E than platelet factor-4 (CXCL4) and showed that CXCL10 and CXCL4L1 could displace each other on microvascular endothelial cells. Labeled CXCL4L1 also bound to CXCR3A- and CXCR3B-transfectants and was displaced by CXCL4L1, CXCL4, and CXCL10. The CXCL4L1 anti-angiogenic activity was blocked by anti-CXCR3 antibodies (Abs) in the Matrigel and cornea micropocket assays. CXCL4L1 application in CXCR3(-/-) or in wild-type mice treated with neutralizing anti-CXCR3 Abs, resulted in reduced inhibitory activity of CXCL4L1 on tumor growth and vascularization of Lewis lung carcinoma. Furthermore, CXCL4L1 and CXCL4 chemoattracted activated T cells, human natural killer cells, and human immature dendritic cells (DCs). Migration of DCs toward CXCL4 and CXCL4L1 was desensitized by preincubation with CXCL10 and CXCL11, inhibited by pertussis toxin, and neutralized by anti-CXCR3 Abs. Chemotaxis of T cells, natural killer cells, and DCs is likely to contribute to the antitumoral action. However, the in vivo data indicate that the angiostatic property of CXCL4L1 is equally important in retarding tumor growth. Thus, both CXCR3A and CXCR3B are implicated in the chemotactic and vascular effects of CXCL4L1.
Structure of the AlaX-Mtrans-editing enzyme fromPyrococcus horikoshii (2007)

The editing domain of alanyl-tRNA synthetase (AlaRS) contributes to high-fidelity aminoacylation by hydrolyzing (editing) the incorrect products Ser-tRNA(Ala) and Gly-tRNA(Ala) (cis-editing). The AlaX protein shares sequence homology to the editing domain of AlaRS. There are three types of AlaX proteins, with different numbers of amino-acid residues (AlaX-S, AlaX-M and AlaX-L). In this report, AlaX-M from Pyrococcus horikoshii is shown to deacylate Ser-tRNA(Ala) and Gly-tRNA(Ala) (trans-editing). The crystal structure of P. horikoshii AlaX-M has been determined at 2.7 A resolution. AlaX-M consists of an N-terminal domain (N-domain) and a C-terminal domain (C-domain). A zinc ion is coordinated by the conserved zinc-binding cluster in the C-domain, which is expected to be the enzymatic active site. The glycine-rich motif, consisting of successive conserved glycine residues in the N-domain, forms a loop (the 'glycine-rich loop'). The glycine-rich loop is located near the active site and may be involved in substrate recognition and/or catalysis.
ANALYSES ON ANTI-TUMOR EFFECTS OF INTERFERON-γ-INDUCING FACTOR/INTERLEUKIN-18 AGAINST MURINE TUMORS (1997)

Osaki, T.; Péron, J. -M.; Cai, Q.; Okamura, H.; Robbins, P. D.; Kurimoto, M.; Lotze, M. T.; Tahara, H. Author Information
Use of Linear Correlation Coefficients in the Analysis of Carrier Density Imaging Recombination Lifetime Maps (2010)

We propose an analytical study of recombination lifetime maps obtained with lock-in Carrier Density Imaging technique. Recombination lifetime maps obtained from the amplitude output (A-) are put in correlation with lifetime maps obtained from phase output (F-) and with real-time maps. The latter encompass the effects of surface morphology and lateral doping variation on the absorption/emission of the mid-infrared radiation (MIR, l=1.5~5 μm) used as detection principle. We use the Carrier Density Imaging setup in absorption mode and the quantifier we adopt is the Pearson (linear) correlation coefficient r. Analysis of the local r maps suggests that strong negative correlation is associated to the surface morphology artifacts present in A- maps, while areas of strong positive correlation can be associated with lateral doping variations, which have a direct impact on the local effective lifetime.
Front Cover: PdBr2‐Catalyzed Acetal Formation of Carbonyl Compounds Using Diazophenanthrenequinone: Utility of 9,10‐Phenanthrenedioxyacetal (Eur. J. Org. Chem. 33/2020) (2020)

The Front Cover shows the new acetalization method of ketones and aldehydes under non-acidic conditions using diazophenanthrenequinone and PdBr2. The formed acetals, that have a phenanthrene skeleton, withstand under mild acidic conditions. Removal of acetals was successfully proceeded under oxidation conditions or strong acidic conditions. We thank our university, Kyushu Institute of Technology, the background colors, polka dots, dark gray and vermilion, are based on the flag of our university. More information can be found in the Communication by M. Kitamura et al.
Determination of the absolute rates of decay of arylcarbenes in various low temperature matrixes by electron spin resonance spectroscopy (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of the absolute rates of decay of arylcarbenes in various low temperature matrixes by electron spin resonance spectroscopyV. P. Senthilnathan and Matthew S. PlatzCite this: J. Am. Chem. Soc. 1980, 102, 26, 7637–7643Publication Date (Print):December 1, 1980Publication History Published online1 May 2002Published inissue 1 December 1980https://doi.org/10.1021/ja00546a003RIGHTS & PERMISSIONSArticle Views82Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (908 KB) Get e-Alerts Get e-Alerts
A single birth dose of Hepatitis B vaccine induces polyfunctional CD4+ T helper cells (2022)

A single birth-dose of Hepatitis B vaccine (HepB) can protect newborns from acquiring Hepatitis B infection through vertical transmission, though several follow-up doses are required to induce long-lived protection. In addition to stimulating antibodies, a birth-dose of HepB might also induce polyfunctional CD4<sup>+</sup> T-cells, which may contribute to initial protection. We investigated whether vaccination with HepB in the first week of life induced detectable antigen-specific CD4<sup>+</sup> T-cells after only a single dose and following completion of the entire HepB vaccine schedule (3 doses). Using HBsAg- stimulated peripheral blood mononuclear cells from 344 infants, we detected increased populations of antigen-specific polyfunctional CD154<sup>+</sup>IL-2<sup>+</sup>TNFα<sup>+</sup> CD4<sup>+</sup> T-cells following a single birth-dose of HepB in a proportion of infants. Frequencies of polyfunctional T-cells increased following the completion of the HepB schedule but increases in the proportion of responders as compared to following only one dose was marginal. Polyfunctional T-cells correlated positively with serum antibody titres following the birth dose (day30) and completion of the 3-dose primary HepB vaccine series (day 128). These data indicate that a single birth dose of HepB provides immune priming for both antigen-specific B- and T cells.
Efficient Encrypted Inference on Ensembles of Decision Trees (2021)

Data privacy concerns often prevent the use of cloud-based machine learning services for sensitive personal data. While homomorphic encryption (HE) offers a potential solution by enabling computations on encrypted data, the challenge is to obtain accurate machine learning models that work within the multiplicative depth constraints of a leveled HE scheme. Existing approaches for encrypted inference either make ad-hoc simplifications to a pre-trained model (e.g., replace hard comparisons in a decision tree with soft comparators) at the cost of accuracy or directly train a new depth-constrained model using the original training set. In this work, we propose a framework to transfer knowledge extracted by complex decision tree ensembles to shallow neural networks (referred to as DTNets) that are highly conducive to encrypted inference. Our approach minimizes the accuracy loss by searching for the best DTNet architecture that operates within the given depth constraints and training this DTNet using only synthetic data sampled from the training data distribution. Extensive experiments on real-world datasets demonstrate that these characteristics are critical in ensuring that DTNet accuracy approaches that of the original tree ensemble. Our system is highly scalable and can perform efficient inference on batched encrypted (134 bits of security) data with amortized time in milliseconds. This is approximately three orders of magnitude faster than the standard approach of applying soft comparison at the internal nodes of the ensemble trees.
Monitoring of electrical equipment failure indicators and zero-planned outages: Past, present and future maintenance practices (2015)

Electrical System Preventive and Predictive Maintenance methodologies have experienced growth due to new available technologies. This paper will review the historical and current approaches to electrical equipment maintenance, and also provide available technologies which support the future modes of equipment maintenance. Low Voltage and Medium Voltage systems will be reviewed. The need for improved reliability and uptime continues and effective monitoring systems support a new concept of Zero-Planned Outages. Monitoring parameters linked to potential failure modes allows for two key needs to be addressed: first, to notify end-users of a pending failure condition; and second, to recommend maintenance and/or inspections based on a trending analysis of failure mode contributing parameters rather than planned outages. This paper shall review both IEEE and end-user surveyed failure indicators and technologies to continuously monitor and alarm on such failure indicators.
Process Intensification Strategies for the Synthesis of Superparamagnetic Nanoparticles and Fabrication of Nano-Hybrid (2008)

Continuous flow spinning disc processing (SDP), which has extremely rapid mixing under plug flow conditions, effective heat and mass transfer, allowing high throughput with low wastage solvent efficiency, is effective in gaining access to superparamagnetic Fe3O4 nanoparticles at room temperature. These are formed by passing ammonia gas over a thin aqueous film of Fe 2+/3+ which is introduced through a jet feed close to the centre of a rapidly rotating disc (500 to 2500 rpm), the particle size being controlled with a narrow size distribution over the range 5 nm to 10 nm, and the material having very high saturation magnetizations, in the range 68–78 emu g -1 . SDP also shown to be effective for fabrication of superparamagnetic carbon nanotubes composite. Ultra fine (2-3 nm) magnetite (Fe3O4) nanoparticles were uniformly deposited on singlewalled carbon nanotubes (SWCNTs) in situ by modified chemical precipitation method using SDP in aqueous media at room temperature under continuous flow condition
Efficient and selective presentation of antigen-antibody complexes by rheumatoid factor B cells. (1991)

Using Epstein-Barr virus B cell clones and antigen-specific T cell clones, we asked how antigen-antibody complexes are handled by B cells. We found that the only B cells capable of efficient presentation of antigen-antibody complexes are those that bind the complexes via membrane immunoglobulin, i.e., rheumatoid factor-producing B cells and, to a lower extent, antigen-specific B cells. On the contrary, nonspecific B cells, although capable of binding antigen-antibody complexes, fail to present them to T cells. Thus, rheumatoid factor B cells can present any antigen in the context of an immune complex and be triggered by T cells specific for a variety of foreign antigens. These results demonstrate a mechanism of intermolecular help that may be responsible for the production of rheumatoid factor and possibly of other types of autoantibodies.
Palladium-Catalyzed Heck Alkynylation of Benzyl Chlorides (2006)

An efficient and general protocol for the palladium-catalyzed Heck alkynylation of benzyl chlorides was developed. A ­catalyst system comprised of PdCl2(CH3CN)2 and 2-dicyclohexyl­phosphino-2′,4′,6′-triisopropylbiphenyl (XPhos), with Cs2CO3 as the base, efficiently couples a wide range of functionalized terminal alkynes and substituted benzyl chlorides at 65 °C. We have also demonstrated that the corresponding aryl allene product can be ­selected for using an excess amount of base and higher reaction temperatures (80 °C) in a one-pot procedure.