gebhart/patrepeval huggingface dataset:
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells (2020)

Pharmacological modulation of cannabinoid type 2 receptor (CB<sub>2</sub>R) holds promise for the treatment of numerous conditions, including inflammatory diseases, autoimmune disorders, pain, and cancer. Despite the significance of this receptor, researchers lack reliable tools to address questions concerning the expression and complex mechanism of CB<sub>2</sub>R signaling, especially in cell-type and tissue-dependent contexts. Herein, we report for the first time a versatile ligand platform for the modular design of a collection of highly specific CB<sub>2</sub>R fluorescent probes, used successfully across applications, species, and cell types. These include flow cytometry of endogenously expressing cells, real-time confocal microscopy of mouse splenocytes and human macrophages, as well as FRET-based kinetic and equilibrium binding assays. High CB<sub>2</sub>R specificity was demonstrated by competition experiments in living cells expressing CB<sub>2</sub>R at native levels. The probes were effectively applied to FACS analysis of microglial cells derived from a mouse model relevant to Alzheimer's disease.
A multiple-channel frontend system with current reuse for fetal monitoring applications (2014)

This paper proposes a multiple-channel frontend system with current reuse for fetal monitoring applications. The structure and specifications of the proposed frontend system are determined while taking into consideration the algorithms used for fetal electrocardiogram (fECG) detection. Two amplifier topologies based on a middle rail current source/sink (MCS) are proposed for fECG and electrohysterogram (EHG) recording. The proposed amplifiers explore power optimization in both current and voltage domain and thus achieve a better effective noise efficiency factor (NEF) while providing multiple-channels. The frontend system is designed in a 0.18μm CMOS process. Simulation results show that the frontend system provides 3 fECG and 4 EHG recoding channels with a total power consumption of 3.1μW. The IA for fECG monitoring achieves an equivalent NEF of 1.17/1.21 for low noise and low power settings respectively.
Fiber laser driven mid-infrared frequency combs (2013)

There was a recent remarkable progress in frequency-comb spectroscopy in the molecular fingerprint region. One key enabling technology was the availability of novel mid-Infrared frequency comb sources driven by fiber-laser technology. We will review recent advances.
Unique electrical characterization and in-line monitoring of nano-tipped defects in metal-insulator-metal capacitors (2009)

The unique characteristics of defective MIM capacitors under nano-ampere current injection and passive voltage contrast have verified the field enhancement and charge accumulation along nanotipped defects. The improved process which reduces the risk of nanowhiskers is confirmed by in-line optical monitoring in production.
Pediatric Cushing Syndrome; an Overview. (2019)

Endogenous Cushing syndrome (CS) is a rare entity in the pediatric population. Patients usually present with height deceleration and continuous weight gain, along with other classic stigmata of CS, such as acne, striae, hirsutism and others. The diagnosis of CS involves documentation of abnormal cortisol secretion with measurement of urinary free cortisol and midnight serum or salivary cortisol, and the use of the 1mg dexamethasone suppression test. After confirmation of CS, localization of the source of hypercortisolemia, involves differentiation of ACTH-dependent versus ACTH-independent causes of CS. Surgical resection of the identified source of CS is the preferred method of treatment whenever possible.
An Improved and Green Preparation of 3-(Alkylthio)propionic Acids (2007)

An efficient, facile microwave-assisted synthesis has been developed for the preparation of unsymmetrical sulfide derivatives from 3-mercaptopropionic acid and a wide variety of alkyl, allyl or aryl chlorides or bromides. The synthesis performed in ethanol at 80 or 120 °C using sodium hydroxide as a base, selectively without an offensive smell, generates 3-(alkylthio)propionic acids in good yields. Effects of reaction components, temperature, and the heating technique on the formation of the product and side-products were studied.
EQUAL: Improving the Fidelity of Quantum Annealers by Injecting Controlled Perturbations (2021)

Quantum computing is an information processing paradigm that uses quantum-mechanical properties to speedup computationally hard problems. Although promising, existing gate-based quantum computers consist of only a few dozen qubits and are not large enough for most applications. On the other hand, existing QAs with few thousand of qubits have the potential to solve some domain-specific optimization problems. QAs are single instruction machines and to execute a program, the problem is cast to a Hamiltonian, embedded on the hardware, and a single quantum machine instruction (QMI) is run. Unfortunately, noise and imperfections in hardware result in sub-optimal solutions on QAs even if the QMI is run for thousands of trials. The limited programmability of QAs mean that the user executes the same QMI for all trials. This subjects all trials to a similar noise profile throughout the execution, resulting in a systematic bias. We observe that systematic bias leads to sub-optimal solutions and cannot be alleviated by executing more trials or using existing error-mitigation schemes. To address this challenge, we propose EQUAL (Ensemble Quantum Annealing). EQUAL generates an ensemble of QMIs by adding controlled perturbations to the program QMI. When executed on the QA, the ensemble of QMIs steers the program away from encountering the same bias during all trials and thus, improves the quality of solutions. Our evaluations using the 2041-qubit D-Wave QA show that EQUAL bridges the difference between the baseline and the ideal by an average of 14% (and up to 26%), without requiring any additional trials. EQUAL can be combined with existing error mitigation schemes to further bridge the difference between the baseline and ideal by an average of 55% (and up to 68%).
Study of the shielding of angular position sensors with magnetic transduction (2016)

Over the past few years, magnetic position sensors have increasingly been chosen over other products and technologies as a result of their high durability, reliability and their ability to be integrated into very small form factors. However, the use of magnetic based sensors is susceptible to interferences when placed in electric vehicles, due to the increasing number of cables. As the electric cables generate stray magnetic fields, especially the ones carrying the high currents from battery to the motor, wrong readings from the magnetic sensors occur, since the amount of external magnetic fields is greater than the maximum disturbance supported by the sensor [1]. The effect of magnetic shielding on an angular position sensor is studied here using an electro-magnetic FEM model (ANSYS Workbench [2]). Permanent magnet, magnetic sensor and disturbance source are modeled and the effect of shielding is extracted from the simulations. Simulation results show that shielding can be achieved using a highly permeable plastic casing.
Photochemically and Thermally Driven Full‐Color Reflection in a Self‐Organized Helical Superstructure Enabled by a Halogen‐Bonded Chiral Molecular Switch (2017)

Supramolecular approaches toward the fabrication of functional materials and systems have been an enabling endeavor. Recently, halogen bonding has been harnessed as a promising supramolecular tool. Herein we report the synthesis and characterization of a novel halogen-bonded light-driven axially chiral molecular switch. The photoactive halogen-bonded chiral switch is able to induce a self-organized, tunable helical superstructure, that is, cholesteric liquid crystal (CLC), when doped into an achiral liquid crystal (LC) host. The halogen-bonded switch as a chiral dopant has a high helical twisting power (HTP) and shows a large change of its HTP upon photoisomerization. This light-driven dynamic modulation enables reversible selective reflection color tuning across the entire visible spectrum. The chiral switch also displays a temperature-dependent HTP change that enables thermally driven red, green, and blue (RGB) reflection colors in the self-organized helical superstructure.
SA-Loc: Scenario Adaptive Localization in Highly Dynamic Environment using Adversarial Regressive Domain Adaptation (2022)

Localization based on signals from cellular base stations (BSs) or WiFi access points is important particularly in urban environments where street canyon effects impair GPS reception. A popular implementation is based on fingerprinting, where associations between channel characteristics and location of a moving terminal (MT) are measured in a training phase, and later (in the testing of operating phase) used to localize an MT measuring a particular channel. This paper considers the combination of labeled and unlabeled channel state information (CSI) for such finger-printing based localization, in particular to account for the fact that moving objects like cars can change the CSI between training and testing. To enhance the robustness of the localization against these and other “unseen” scenarios, we propose a solution approach based on a deep domain adaptation (DA) framework. The proposed method contains an unsupervised domain adaptation regression and an adversarial training module. The first component aims to learn discriminative fingerprinting representations jointly with data collected from seen and unseen scenes. The second one alleviates the distribution divergence of fingerprints collected from seen and unseen scenes, which eventually enables effective knowledge transfer. Finally, we evaluate the performance of the proposed method in a challenging setup, the recently released dynamic scenario in the DeepMIMO dataset. The results demonstrate that the proposed method can provide robust and accurate location estimation over variable numbers of the time-varying scenarios, with superior performance over other compared methods.
An efficient strategy for developing a simulator for a novel concurrent multithreaded processor architecture (2002)

In developing a simulator for a new processor architecture, it often is not clear whether it is more efficient to write a new simulator or to modify an existing simulator. Writing a new simulator forces the processor architect to develop or adapt all of the related software tools. However, modifying an existing simulator and related tools, which are usually not well-documented, can be time-consuming and error-prone. We describe the SImulator for Multithreaded Computer Architectures (SIMCA) that was developed with the primary goal of obtaining a functional simulator as quickly as possible to begin evaluating the superthreaded architecture. The performance of the simulator itself was important, but secondary. We achieved our goal using a technique called process-pipelining that exploits the unique features of this new architecture to hide the details of the underlying simulator. This approach allowed us to quickly produce a functional simulator whose performance is only 3.8-4.9 times slower than the base simulator.
Plasma Inactive Renin in Patients with Hyperthyroidism (1983)

Active and inactive PRA were measured after 1 h at rest in 16 normal controls and 20 patients with hyperthyroidism. In some of the patients these measurements were repeated after they had become euthyroid or received 90 mg propranolol for 1 week. Inactive PRA was determined as the difference between total PRA after trypsin activation and active PRA. Active PRA was significantly higher (P less than 0.01) in untreated patients than in normal subjects; however, the inactive PRA of patients was not different compared with that of normal subjects. Active PRA was normalized, and inactive PRA did not change after achievement of euthyroidism. The proportion of active of total PRA was significantly correlated with the levels of serum thyroid hormones (T3 and T4) in hyperthyroid patients (r = 0.46; P less than 0.05 and r = 0.55; P less than 0.01, respectively). The administration of propranolol reduced active PRA (P less than 0.05) and increased inactive PRA slightly but not significantly. These results indicate that in hyperthyroidism, the in vivo conversion of inactive renin to active renin is probably facilitated by increased sympathetic activity.
A new configuration for small-size Fabry-Perot cavity antennas with large bandwidth for space applications (2009)

International audience
ChemInform Abstract: Synthesis of Amino Sugars Through a Highly Diastereoselective Dipolar Cycloaddition. Enantioselective Synthesis of the Carbohydrate Segment of Sch 38516. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Design of protection and distribution service model for digital broadcasting content (2005)

DRM (digital rights management) technologies support the protection of intellectual properties against illegal actions. Due the development of digital broadcasting technology and storage media such as PVR (personal video recorder), it is possible for the viewer to watch and to acquire digital broadcasting content of high quality. For digital broadcasting content, therefore, DRM technologies can be applicable in order to prohibit illegal usage by the viewer. We designed a protection and distribution service model for broadcast content in which the license is issued to the viewer who recorded it on his storage media.
This Month in Investigative Urology (2007)

No AccessJournal of UrologyThis month in investigative urology1 Feb 2008This Month in Investigative Urology Anthony Atala Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2007.11.005AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "This Month in Investigative Urology." The Journal of Urology, 179(2), pp. 400–401 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 2February 2008Page: 400-401 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF DownloadLoading ...
High-amplitude motion cancellation method for handheld UWB Doppler radar (2014)

UWB Doppler radar is capable of monitoring vital signs of human beings in a non-contact way by detecting the changes in the time of flight of narrow pulses emitted by the radar and reflected from the human chest. However, the received signal may be corrupted when there is a random motion if handheld UWB radar is used, especially when the amplitude of motion is higher than that of the thoracic motion. In this paper, a random motion cancellation method using an embedded system is proposed for recovering the real vital signs similar to image stabilization in optical cameras. The proposed embedded system is attached to the receiving antenna and used to collect the data of motion acceleration. The correlation between the data collected by the UWB system and embedded system is analyzed and a Finite Impulse Response (FIR) model considering the time delay between these two systems is developed as well. Experiments show that the respiration rate of a subject can be accurately recovered by motion cancellation method even in the presence of a high-amplitude motion of the receiver.
XDD: Cross Division Duplex in 5G-Advanced (2021)

In this paper, an advanced duplex scheme, referred to as cross division duplex (XDD), is proposed to use flexible downlink (DL) and uplink (UL) allocation in time division duplex (TDD) carrier. By implementing self-interference cancellation (SIC) functions at the base station, the proposed XDD enables to simultaneously operate UL and DL on different frequency subband in the same channel. To do so, both TDD&#x0027;s ability to efficiently handle asymmetric UL and DL traffic and frequency division duplexing&#x0027;s coverage and latency advantage can be achieved together. To verify the feasibility of XDD, a Proof-of-Concept is developed and self-interference can be removed almost perfectly with proper implementation of SIC without guardband between DL and UL subband. From evaluation results, UL coverage, as well as latency, was improved using a longer UL duty period in XDD. Based on XDD, in 5G-Advanced, a significantly higher resource utilization than the existing 5G will be possible.
Inkjet Printing of Mixed-Host Emitting Layer for Electrophosphorescent Organic Light-Emitting Diodes (2019)

We have investigated the impact of the ink formulation on the properties of an inkjet-printed small molecular mixed host in a phosphorescent organic light-emitting diode (PhOLED). Host solubility, film roughness, and device efficiency improved by blending tris(4-carbazoyl-9-ylphenyl)amine (TCTA) with pyrido[3',2':4,5]furo[2,3- b]pyridine (3CzPFP). At a host ratio of 60:40 (TCTA/3CzPFP), the brightness increased by 33%, the efficiency roll-off at 1000 cd/m<sup>2</sup> dropped to well below 10%, and the luminance half-lifetime (LT<sub>50</sub>) improved by 80% in comparison to the device with a single host (100% TCTA). When the optimized ink was deposited by inkjet printing, a maximum external quantum efficiency of 8.9% and a current efficiency of 28.8 cd/A were achieved at 1000 cd/m<sup>2</sup> brightness. This amounted to around 84% of the efficiency of a spin-cast reference device. The obtained results provide a blueprint for designing enhanced PhOLEDs with inkjet-printed mixed hosts.
Cronkhite Canada Syndrome: Significant Response to Infliximab and a Possible Clue to Pathogenesis (2016)

Boland, Brigid S MD1,2; Bagi, Preet MD2; Valasek, Mark A MD, PhD3; Chang, John T MD1,2,4; Bustamante, Ranier MS4; Madlensky, Lisa PhD, CGC5; Sandborn, William J MD1,2; Harismendy, Olivier PhD1,6; Gupta, Samir MD, MSCS1,4,6 Author Information
Suppressor of Cytokine Signaling 3 Is an Inducible Host Factor That Regulates Virus Egress during Ebola Virus Infection (2015)

The VP40 matrix protein is a key structural protein critical for Ebola virus budding. Physical and functional interactions between VP40 and host proteins such as Tsg101 and Nedd4 facilitate efficient release of VLPs and infectious virus. We reported that host TLR4 is a sensor for Ebola GP on VLPs and that the resultant TLR4 signaling pathways lead to the production of proinflammatory cytokines. Host SOCS3 regulates the innate immune response by controlling and limiting the proinflammatory response through negative-feedback inhibition of cytokine receptors. We present evidence that Ebola virus VLPs stimulate induction of SOCS3 as well as proinflammatory cytokines, and that expression of human SOCS3 enhances budding of Ebola VLPs and infectious virus via a mechanism linked to the host ubiquitinylation machinery.
The sex‐shift in single disease and multimorbid asthma and rhinitis during puberty ‐ a study by MeDALL (2017)

The male predominance in prevalence before puberty and the "sex-shift" towards females after puberty onset were strongest in multimorbid patients who had asthma and rhinitis concurrently.
Bio-inspired Hardware Central Pattern Generator (hCPG) as a Therapy for Cardiorespiratory Disease (2016)

We report on a hCPG device, which is a network of silicon neurons, and its applications to cardiorespiratory therapy. We study the chaotic dynamics of neurons that compete through mutually inhibitory synapses and demonstrate the emergence of multistable behavior. We were able to select the spatio-t
Materials Development for SOFC Applications (2009)

As solid oxide fuel cell technology enters product commercialization, low cost manufacturing and long-term stability of SOFC is critical to the success in the industry. Materials that can be produced in a scalable manner and simply integrated into stack manufacturing are important to achieve these goals. In this paper, materials evaluations of low temperature cathodes, interconnect coatings and contact paste development are reviewed.
Infection in Health Personnel with High and Low Levels of Exposure in a Hospital Setting during the H1N1 2009 Influenza A Pandemic (2016)

A novel H1N1 influenza A virus caused the first pandemic of the 21st century in 2009. Hospitals had an increased demand of health consultations, that made it difficult to estimate the incidence of infection in hospital personnel due to asymptomatic presentations and the under notification of cases. To estimate and compare the rate of exposure of high versus low risk health personnel to 2009 pandemic H1N1 (H1N1pdm2009) influenza A virus in a University Hospital in Chile, we performed a comparative and prospective study. Serum samples were obtained from 117 individuals that worked in the emergency room (ER) and the operating room (OR) during the peak of the pandemic. Antibody titers were determined by the hemagglutination inhibition (HI) assay. Of the samples analyzed, 65% were workers at the ER and 35% at the OR. Of the total number of the subjects tested, 29.1% were seropositive. One out of 3 (36.8%) workers at the ER had positive HI titers, meanwhile only 1 out of 7 (14.6%) workers from the OR was seropositive to the virus. The possibility of being infected in the ER as compared to the OR was 3.4 times greater (OR 3.4; CI 95%, 1.27-9.1), and the individuals of the ER had almost twice as much antibody titers against H1N1pdm2009 than the personnel in the OR, suggesting the potential of more than one exposure to the virus. Of the 34 seropositive subjects, 12 (35.3%) did not develop influenza like illness, including 2 non-clinical personnel involved in direct contact with patients at the ER. Considering the estimated population attack rate in Chile of 13%, both groups presented a higher exposure and seropositive rate than the general population, with ER personnel showing greater risk of infection and a significantly higher level of antibodies. This data provide a strong rationale to design improved control measures aimed at all the hospital personnel, including those coming into contact with the patients prior to triage, to prevent the propagation and transmission of respiratory viruses, particularly during a pandemic outbreak.
ChemInform Abstract: Natural Glycans and Glycoconjugates as Immunomodulating Agents (2011)

Abstract Review: 163 refs.
Supplementary Figure 1 from Preferential Replication of Systemically Delivered Oncolytic Vaccinia Virus in Focally Irradiated Glioma Xenografts (2023)

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TG01/GM-CSF and adjuvant gemcitabine in patients with resected RAS-mutant adenocarcinoma of the pancreas (CT TG01-01): a single-arm, phase 1/2 trial (2020)

This clinical trial was registered at ClinicalTrials.gov (NCT02261714).
Comparing american and palestinian perceptions of charisma using acoustic-prosodic and lexical analysis (2007)

Charisma, the ability to lead by virtue of personality alone, is difﬁcult to deﬁne but relatively easy to identify. However, cultural factors clearly affect perceptions of charisma. In this paper we compare results from parallel perception studies investigating charismatic speech in Palestinian Arabic and American English. We examine acoustic/prosodic and lexical correlates of charisma ratings to determine how the two cultures differ with respect to their views of charismatic speech.
ChemInform Abstract: Total Synthesis of Trilobin. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.