gebhart/patrepeval huggingface dataset:
Overexpression of c-met as a Prognostic Indicator for Transitional Cell Carcinoma of the Urinary Bladder: A Comparison With p53 Nuclear Accumulation (2002)

The c-met proto-oncogene plays a more important role in the progression of bladder carcinogenesis than p53. Evaluation of Met expression could identify a subset of bladder cancer patients who may require a more intensive treatment strategy.
Electro-Deposited Primer Development and Low-Polluting Primer Evaluation (1989)

Abstract : The objectives of this Air Force program are to develop, evaluate, demonstrate, and qualify an electro-deposited (ED) corrosion resistant primer system for metal bonding suitable for use with 350 F curing adhesives and to evaluate other low-polluting primer systems (such as water-base spray and dip systems or inorganic primers) which would be suitable for use with 350 F curing adhesives. Several electro-deposited primer formulations were evaluated to determine the optimum primer. The best primer developed met all of the initial adhesive bonded corrosion performance criteria in the laboratory. Scale-up to 6- gallon, and eventually 200-gallon demonstration of the electro-deposited priming process was planned; however, the primer was not successfully demonstrated. Additional work on the primer formulation and/or process equipment design is necessary and could not be accomplished within the provisions of this contract. Water-base primers were tested; the most promising was further tested and readily exceeded program requirements. Keywords: Adhesive bonding; Electro-deposited primer; Water-base primer; Metal bonding; Corrosion resistance.
SETD2 Is Recurrently Mutated in Whole-Exome Sequenced Canine Osteosarcoma (2018)

Osteosarcoma is a debilitating bone cancer that affects humans, especially children and adolescents. A homologous form of osteosarcoma spontaneously occurs in dogs, and its differential incidence observed across breeds allows for the investigation of tumor mutations in the context of multiple genetic backgrounds. Using whole-exome sequencing and dogs from three susceptible breeds (22 golden retrievers, 21 Rottweilers, and 23 greyhounds), we found that osteosarcoma tumors show a high frequency of somatic copy-number alterations (SCNA), affecting key oncogenes and tumor-suppressor genes. The across-breed results are similar to what has been observed for human osteosarcoma, but the disease frequency and somatic mutation counts vary in the three breeds. For all breeds, three mutational signatures (one of which has not been previously reported) and 11 significantly mutated genes were identified. <i>TP53</i> was the most frequently altered gene (83% of dogs have either mutations or SCNA in <i>TP53</i>), recapitulating observations in human osteosarcoma. The second most frequently mutated gene, histone methyltransferase <i>SETD2</i>, has known roles in multiple cancers, but has not previously been strongly implicated in osteosarcoma. This study points to the likely importance of histone modifications in osteosarcoma and highlights the strong genetic similarities between human and dog osteosarcoma, suggesting that canine osteosarcoma may serve as an excellent model for developing treatment strategies in both species.<b>Significance:</b> Canine osteosarcoma genomics identify SETD2 as a possible oncogenic driver of osteosarcoma, and findings establish the canine model as a useful comparative model for the corresponding human disease. <i>Cancer Res; 78(13); 3421-31. ©2018 AACR</i>.
Blast-Associated Shock Waves Result in Increased Brain Vascular Leakage and Elevated ROS Levels in a Rat Model of Traumatic Brain Injury (2015)

Blast-associated shock wave-induced traumatic brain injury (bTBI) remains a persistent risk for armed forces worldwide, yet its detailed pathophysiology remains to be fully investigated. In this study, we have designed and characterized a laboratory-scale shock tube to develop a rodent model of bTBI. Our blast tube, driven by a mixture of oxygen and acetylene, effectively generates blast overpressures of 20-130 psi, with pressure-time profiles similar to those of free-field blast waves. We tested our shock tube for brain injury response to various blast wave conditions in rats. The results show that blast waves cause diffuse vascular brain damage, as determined using a sensitive optical imaging method based on the fluorescence signal of Evans Blue dye extravasation developed in our laboratory. Vascular leakage increased with increasing blast overpressures and mapping of the brain slices for optical signal intensity indicated nonhomogeneous damage to the cerebral vasculature. We confirmed vascular leakage due to disruption in the blood-brain barrier (BBB) integrity following blast exposure. Reactive oxygen species (ROS) levels in the brain also increased with increasing blast pressures and with time post-blast wave exposure. Immunohistochemical analysis of the brain sections analyzed at different time points post blast exposure demonstrated astrocytosis and cell apoptosis, confirming sustained neuronal injury response. The main advantages of our shock-tube design are minimal jet effect and no requirement for specialized equipment or facilities, and effectively generate blast-associated shock waves that are relevant to battle-field conditions. Overall data suggest that increased oxidative stress and BBB disruption could be the crucial factors in the propagation and spread of neuronal degeneration following blast injury. Further studies are required to determine the interplay between increased ROS activity and BBB disruption to develop effective therapeutic strategies that can prevent the resulting cascade of neurodegeneration.
CMV Antibody Immunity as a Predictor of a CMV-Specific Cellular Immune Response (2004)

s for the 19th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer, San Francisco, California, November 4-7, 2004: Immune Monitoring
Massive MU-MIMO-OFDM Uplink with Hardware Impairments: Modeling and Analysis (2018)

We study the impact of hardware impairments at the base station (BS) of an orthogonal frequency-division multiplexing (OFDM)-based massive multiuser (MU) multiple-input multiple-output (MIMO) uplink system. We leverage Bussgang's theorem to develop accurate models for the distortions caused by nonlinear low-noise amplifiers, local oscillators with phase noise, and over-sampling finite-resolution analog-to-digital converters. By combining the individual effects of these hardware models, we obtain a composite model for the BS-side distortion caused by nonideal hardware that takes into account its inherent correlation in time, frequency, and across antennas. We use this composite model to analyze the impact of BS-side hardware impairments on the performance of realistic massive MU-MIMO-OFDM uplink systems.
Detection of Hepatocellular Carcinoma Using Glycomic Analysis (2009)

A set of three identified N-glycans is sufficient for the detection of HCC with 90% prediction accuracy in a population with high rates of hepatitis C viral infection. Further evaluation of a wider clinical utility of these candidate markers is warranted.
SIMULTANEOUS REPLACEMENTS OF TRIETHYL PHOSPHINE AND TETRAACETYL THIOGLUCOSE LIGANDS FROM AURANOFIN (AN ANTIARTHRITIC DRUG) WITH SELENOCYANATE 13C and 31P NMR STUDIES (1998)

Abstract The interaction of SeCN− with a new gold-based antiarthritic drug auranofin (Et3PAuSATg, where SATg− = 2, 3, 4, 6-tetra-O-acetyl-l-thio-β-D-glucopyranosato-S) in aqueous methanol has been studied by 13C and 31P NMR spectroscopy. It is observed that SeCN−releases bom ligands (i. e., SATg− and Et3P) to form [ATgS-Au-CN]− and [Et3P-Au-SeCN]. These newly generated species undergo further disproportionation and decomposition to generate species such as [(Et3P)2Au]+, [Au(CN)2]−, Et3PO and metallic selenium. The formation of [(Et3P)2Au]+ and [Au(CN)2]− is found to be much faster for Et3PAuNO3 than for Et3PAuSATg when reacted wim SeCN−. Exchange between unlabelled CN− of Au(CN)2 − and labelled Se13CN− was observed without selenium being precipitated from Se13CN−.
Endonasal CNS Delivery System for Blood-Brain Barrier Impermeant Therapeutic Oligonucleotides Using Heterotopic Mucosal Engrafting (2021)

The most significant obstacle in the treatment of neurological disorders is the blood-brain barrier (BBB), which prevents 98% of all potential neuropharmaceuticals from reaching the central nervous system (CNS). Brain derived neurotrophic factor (BDNF) is one of the most intensely studied targets in Parkinson's disease (PD) as it can reverse disease progression. BDNF AntagoNAT's (ATs) are synthetic oligonucleotide-like compounds capable of upregulating endogenous BDNF expression. Despite the significant promise of BDNF AT therapies for PD, they cannot cross the blood-brain barrier (BBB). Our group has developed an innovative endonasal heterotopic mucosal grafting technique to provide a permanent method of permeabilizing the BBB. This method is based on established endoscopic surgical procedures currently used in routine clinical practice. Our overall goal for the study was to investigate the distribution and efficacy of BDNF AT's using an extra-cranial graft model in naïve rats using the innovative heterotopic mucosal engrafting technique. BDNF AT cationic liposomes (ideal size range 200-250 nm) were developed and characterized to enhance the delivery to rat brain. Uptake, distribution and transfection efficiency of BDNF AntagoNAT's in saline and liposomes were evaluated qualitatively (microscopy) and quantitatively (ELISA and AT hybridization assays) in RT4-D6P2T rat schwannoma cells and in naïve rats. <i>In vivo</i> therapeutic efficacy of BDNF AT's encapsulated in liposomes was evaluated in a 6-OHDA toxin model of PD using western blot and tyrosine hydroxylase immunohistochemistry. Using complimentary <i>in vitro</i> and <i>in vivo</i> techniques, our results demonstrate that grafts are capable of delivering therapeutic levels of BDNF ATs in liposomes and saline formulation throughout the brain resulting in significant BDNF upregulation in key end target regions relevant to PD. BDNF AT liposomes resulted in a better distribution in rat brain as compared to saline control. The delivered BDNF AT's encapsulated in liposomes also conferred a neuroprotective effect in a rat 6-OHDA model of PD. As a platform technique, these results further suggest that this approach may be utilized to deliver other BBB impermeant oligonucleotide-based therapeutics thereby opening the door to additional treatment options for CNS disease.
Lipophilic Dye Staining ofCryptococcus neoformansExtracellular Vesicles and Capsule (2009)

Cryptococcus neoformans is an encapsulated yeast that causes systemic mycosis in immunosuppressed individuals. Recent studies have determined that this fungus produces vesicles that are released to the extracellular environment both in vivo and in vitro. These vesicles contain assorted cargo that includes several molecules associated with virulence and implicated in host-pathogen interactions, such as capsular polysaccharides, laccase, urease, and other proteins. To date, visualization of extracellular vesicles has relied on transmission electron microscopy, a time-consuming technique. In this work we report the use of fluorescent membrane tracers to stain lipophilic structures in cryptococcal culture supernatants and capsules. Two dialkylcarbocyanine probes with different spectral characteristics were used to visualize purified vesicles by fluorescence microscopy and flow cytometry. Dual staining of vesicles with dialkylcarbocyanine and RNA-selective nucleic acid dyes suggested that a fraction of the vesicle population carried RNA. Use of these dyes to stain whole cells, however, was hampered by their possible direct binding to capsular polysaccharide. A fluorescent phospholipid was used as additional membrane tracer to stain whole cells, revealing punctate structures on the edge of the capsule which are consistent with vesicular trafficking. Lipophilic dyes provide new tools for the study of fungal extracellular vesicles and their content. The finding of hydrophobic regions in the capsule of C. neoformans adds to the growing evidence for a structurally complex structure composed of polysaccharide and nonpolysaccharide components.
Impact of Gas System Modelling on Uncertainty Management of Gas-Electric Systems (2022)

Gas fired power plants can provide flexible generation that can help to balance intermittent renewable energy sources as the world moves towards using a more sustainable energy infrastructure. The increasing use of gas-fired power plants for balancing renewable generation creates an interdependence between the electricity and gas networks, where uncertainty can propagate between the two systems, causing insecure operating conditions and disruptions in both gas and electricity supply. Unfortunately, these interactions are computationally challenging to analyze due to the relatively longer transient dynamics of the gas network models. Recent work have provided efficient methods for solving problem as a two stage stochastic optimization problem. In this paper we investigate the importance of using a dynamic gas network model, as compared to a simplified steady-state network model which ignores gas system transients. We find that using the dynamic model allows the networks to better manage the uncertainty of the renewable energy sources and results in lower costs and reduced load shedding.
Frequency Domain Analysis of Signals With Stochastic Sampling Times (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> In nonuniform sampling (NUS), signal amplitudes and time stamps are delivered in pairs. Several methods to compute an approximate Fourier transform (AFT) have appeared in literature, and their posterior properties in terms of alias suppression and leakage have been addressed. In this paper, the sampling times are assumed to be generated by a stochastic process. The main result gives the prior distribution of several AFTs expressed in terms of the true Fourier transform and variants of the characteristic function of the sampling time distribution. The result extends leakage and alias suppression with bias and variance terms due to NUS. Specific sampling processes as described in literature are analyzed in detail. The results are illustrated on simulated signals, with particular focus to the implications for spectral estimation. </para>
EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts (2009)

Receptor tyrosine kinase (RTK) systems, such as hepatocyte growth factor (HGF) and its receptor c-Met, and epidermal growth factor receptor (EGFR), are responsible for the malignant progression of multiple solid tumors. Recent research shows that these RTK systems comodulate overlapping and dynamically adaptable oncogenic downstream signaling pathways. This study investigates how EGFRvIII, a constitutively active EGFR deletion mutant, alters tumor growth and signaling responses to RTK inhibition in PTEN-null/HGF(+)/c-Met(+) glioma xenografts. We show that a neutralizing anti-HGF monoclonal antibody (L2G7) potently inhibits tumor growth and the activation of Akt and mitogen-activated protein kinase (MAPK) in PTEN-null/HGF(+)/c-Met(+)/EGFRvIII(-) U87 glioma xenografts (U87wt). Isogenic EGFRvIII(+) U87 xenografts (U87-EGFRvIII), which grew five times more rapidly than U87-wt xenografts, were unresponsive to EGFRvIII inhibition by erlotinib and were only minimally responsive to anti-HGF monoclonal antibodies. EGFRvIII expression diminished the magnitude of Akt inhibition and completely prevented MAPK inhibition by L2G7. Despite the lack of response to L2G7 or erlotinib as single agents, their combination synergized to produce substantial antitumor effects (inhibited tumor cell proliferation, enhanced apoptosis, arrested tumor growth, prolonged animal survival), against subcutaneous and orthotopic U87-EGFRvIII xenografts. The dramatic response to combining HGF:c-Met and EGFRvIII pathway inhibitors in U87-EGFRvIII xenografts occurred in the absence of Akt and MAPK inhibition. These findings show that combining c-Met and EGFRvIII pathway inhibitors can generate potent antitumor effects in PTEN-null tumors. They also provide insights into how EGFRvIII and c-Met may alter signaling networks and reveal the potential limitations of certain biochemical biomarkers to predict the efficacy of RTK inhibition in genetically diverse cancers.
julia v0.4.0-rc3 (2015)

All major 0.4 changes are in, we continue with bugfixes and backports toward a final 0.4 release. A prepared tarball (the output of make light-source-dist) is attached below in julia-0.4.0-rc3_483d548272.tar.gz, use this if a source tarball is desired, as it contains a small amount of preparation that a simple archive of the git repository does not. For source builds in restricted environments (e.g. no network access) use the output of make full-source-dist attached below in julia-0.4.0-rc3_483d548272-full.tar.gz as it already contains all dependencies pre-downloaded and ready for compilation.
A Virtual Collection Focused on Antifungal Drug Discovery (2022)

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTA Virtual Collection Focused on Antifungal Drug DiscoveryCraig W. LindsleyCraig W. LindsleyMore by Craig W. Lindsleyhttps://orcid.org/0000-0001-9261-594X, Dennis C. LiottaDennis C. LiottaMore by Dennis C. Liottahttps://orcid.org/0000-0003-0168-1445, and Courtney C. AldrichCourtney C. AldrichMore by Courtney C. Aldrichhttps://orcid.org/0000-0002-7736-7113Cite this: ACS Infect. Dis. 2022, 8, 3, 399Publication Date (Web):February 4, 2022Publication History Received10 January 2022Published online4 February 2022Published inissue 11 March 2022https://pubs.acs.org/doi/10.1021/acsinfecdis.2c00018https://doi.org/10.1021/acsinfecdis.2c00018editorialACS PublicationsCopyright © 2022 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views968Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (525 KB) Get e-AlertscloseSUBJECTS:Antimicrobial agents,Drug discovery,Fungi,Infectious diseases,Pharmaceuticals Get e-Alerts
Europium(III) trisbipyridine cryptate label for time-resolved fluorescence detection of polymerase chain reaction products fixed on a solid support (1993)

We report a method for the nonradioactive detection of specific amplified target DNA, based on a new long-lived fluorescent label, europium(III) trisbipyridine cryptate [TBP-(Eu3+)]. After a polymerase chain reaction with a set of nested primers, microtiter affinity-collected hybrids were recognized by a TBP(Eu3+)-labeled antibody. The particular structure of the label containing the energy transfer units (bipyridine moieties) enables direct fluorescence measurement on the solid phase. Moreover, its stability and long lifetime contribute to the enhancement of the signal-to-noise ratio. The usefulness of this new label is illustrated by the detection of human papillomavirus type 16 DNA in clinical smears.
Virtual reference feedback tuning with Bayesian regularization (2016)

Virtual Reference Feedback Tuning (VRFT) is a well established tool to design model-reference controllers directly from input-output data. A major drawback of the method lies in that the variance of the controller is high, due to the instrumental variable method employed to obtain unbiased estimates. Recent results on the use of kernel-based regularization in system identification showed that a good bias-variance trade-off can be found by suitably tuning a penalty term in the identification criterion within a Bayesian framework. In this paper, we apply such a regularization approach to the VRFT method and we show that significant performance improvement can be obtained also for controller design. A benchmark example is used to illustrate the effectiveness of the proposed approach.
Differences in baseline characteristics, practice patterns and clinical outcomes in contemporary coronary artery bypass grafting in the United States and Europe: insights from the SYNTAX randomized trial and registry (2014)

Repeat revascularization rates following CABG in the USA versus Europe were increased at 5 years, particularly in off-pump patients. There was no significant difference in the rate of death, stroke and MI.
(4S,5R,6R)-Methyl 4-hydroxy-4,5-isopropylidenedioxy-4,5,6,7-tetrahydro-1,2,3-triazolo[1,5-a]pyridine-3-carboxylate (2009)

X-ray crystallography confirmed the structure of the title triazole, C(11)H(15)N(3)O(5), formed from a single-step reaction of a sugar azide with a brominated ylid. The absolute configuration was determined by the use of d-ribose as the starting material. The six-membered ring is in a half-chair conformation. The crystal structure exists as chains of O-H⋯O hydrogen-bonded moleclues running parallel to the b axis.
A zero-voltage switching four-port integrated DC/DC converter (2010)

This paper proposes a novel converter topology that interfaces four power ports: two sources, one bidirectional storage port, and one isolated load port. The proposed four-port DC/DC converter is derived by simply adding two switches and two diodes to the traditional half-bridge topology. Zero-voltage switching is realized for all four main switches. Three of the four ports can be tightly regulated by adjusting three independent duty cycle values, while the forth port is left unregulated to maintain the power balance for the system. Circuit analysis and design considerations are presented; the control structure is given as well. Experimental results verify the proposed topology and confirm its ability to achieve tight independent control over three power processing paths. The proposed topology and control is particularly relevant to battery-backed power systems having multiple renewable sources.
Learning to Find Good Models in RANSAC (2022)

We propose the Model Quality Network, MQ-Net in short, for predicting the quality, e.g. the pose error of essential matrices, of models generated inside RANSAC. It replaces the traditionally used scoring techniques, e.g., inlier counting of RANSAC, truncated loss of MSAC, and the marginalization-based loss of MAGSAC++. Moreover, Minimal samples Filtering Network (MF-Net) is proposed for the early rejection of minimal samples that likely lead to degenerate models or to ones that are inconsistent with the scene geometry, e.g., due to the chirality constraint. We show on 54450 image pairs from public real-world datasets that the proposed MQ-Net leads to results superior to the state-of-the-art in terms of accuracy by a large margin. The proposed MF-Net accelerates the fundamental matrix estimation by five times and significantly reduces the essential matrix estimation time while slightly improving accuracy as well. Also, we show experimentally that consensus maximization, i.e. inlier counting, is not an inherently good measure of the model quality for relative pose estimation. The code is at https://github.com/danini/learning-goad-models-in-ransac.
Flux growth and laser operation of highly Yb3+-doped cubic Gd2O3 laser crystals (orale) (2013)

International audience