gebhart/patrepeval huggingface dataset:
Changes in cortical network connectivity with long-term brain-machine interface exposure after chronic amputation (2017)

Studies on neural plasticity associated with brain-machine interface (BMI) exposure have primarily documented changes in single neuron activity, and largely in intact subjects. Here, we demonstrate significant changes in ensemble-level functional connectivity among primary motor cortical (MI) neurons of chronically amputated monkeys exposed to control a multiple-degree-of-freedom robot arm. A multi-electrode array was implanted in M1 contralateral or ipsilateral to the amputation in three animals. Two clusters of stably recorded neurons were arbitrarily assigned to control reach and grasp movements, respectively. With exposure, network density increased in a nearly monotonic fashion in the contralateral monkeys, whereas the ipsilateral monkey pruned the existing network before re-forming a denser connectivity. Excitatory connections among neurons within a cluster were denser, whereas inhibitory connections were denser among neurons across the two clusters. These results indicate that cortical network connectivity can be modified with BMI learning, even among neurons that have been chronically de-efferented and de-afferented due to amputation.
Epitaxial Growth of Thin Ferroelectric Polymer Films on Graphene Layer for Fully Transparent and Flexible Nonvolatile Memory (2015)

Enhancing the device performance of organic memory devices while providing high optical transparency and mechanical flexibility requires an optimized combination of functional materials and smart device architecture design. However, it remains a great challenge to realize fully functional transparent and mechanically durable nonvolatile memory because of the limitations of conventional rigid, opaque metal electrodes. Here, we demonstrate ferroelectric nonvolatile memory devices that use graphene electrodes as the epitaxial growth substrate for crystalline poly(vinylidene fluoride-trifluoroethylene) (PVDF-TrFE) polymer. The strong crystallographic interaction between PVDF-TrFE and graphene results in the orientation of the crystals with distinct symmetry, which is favorable for polarization switching upon the electric field. The epitaxial growth of PVDF-TrFE on a graphene layer thus provides excellent ferroelectric performance with high remnant polarization in metal/ferroelectric polymer/metal devices. Furthermore, a fully transparent and flexible array of ferroelectric field effect transistors was successfully realized by adopting transparent poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine] semiconducting polymer.
Controlled Redox of Lithium-Ion Endohedral Fullerene for Efficient and Stable Metal Electrode-Free Perovskite Solar Cells (2019)

High efficiency perovskite solar cells have underpinned the rapid growth of the field. However, their low device stability limits further advancement. Hygroscopic lithium bis(trifluoromethanesulfonyl)imide (Li<sup>+</sup>TFSI<sup>-</sup>) and metal electrode are the main causes of the device instability. In this work, the redox reaction between lithium-ion endohedral fullerenes and 2,2',7,7'-tetrakis(<i>N</i>,<i>N</i>-di-<i>p</i>-methoxyphenylamine)-9,9'-spirobi-fluorene (spiro-MeOTAD) was controlled to optimize the amount of oxidized spiro-MeOTAD and antioxidizing neutral endohedral fullerenes. Application of this mixture to metal-free carbon nanotube (CNT)-laminated perovskite solar cells resulted in 17.2% efficiency with a stability time of more than 1100 h under severe conditions (temperature = 60 °C, humidity = 70%). Such high performance is attributed to the uninhibited charge flow, no metal-ion migration, and the enhanced antioxidizing activity of the devices.
An Achievability Scheme for the Compound Channel with State Noncausally Available at the Encoder (2010)

A new achievability scheme for the compound channel with discrete memoryless (DM) state noncausally available at the encoder is established. Achievability is proved using superposition coding, Marton coding, joint typicality encoding, and indirect decoding. The scheme is shown to achieve strictly higher rate than the straightforward extension of the Gelfand-Pinsker coding scheme for a single DMC with DM state, and is optimal for some classes of channels.
Fully autonomous multiple-jammer suppression (2017)

For the first time, a fully autonomous jammer suppressor is presented that can suppress two jammers. A system consisting of a 4-pole absorptive bandstop filter (ABSF), a novel multi-jammer detector, and an open-loop filter tuner is described and demonstrated. The ABSF enables high isolation at two frequencies with planar resonators. The jammer detector can identify the location of two jammers in 100 ms-order speeds and can be designed to trade off bandwidth and accuracy while maintaining detection speed. The open-loop filter tuner enables accurate tuning of the ABSF without costly filter feedback through the use of a post-fabrication-calibrated surrogate model. With a single jammer, the system provides fully autonomous suppression of 3055 dB from 1600-2100 MHz. In the presence of two jammers, up to 56 dB suppression is measured with an average of 30-48 dB suppression in the ABSF absorptive region of 1910-2100 MHz.
Possible psychopharmacological agents. Part 7: Synthesis and CNS activity of some fluorinated 2,4,7/8-trisubstituted-3H-1,5-benzodiazepinium monoperchlorates. (1979)

A series of new fluorinated 2,4'7/8-trisubstituted-3H-1,5-benzodiazepinium monoperchlorates have been synthesized and characterized by IR and NMR spectral studies. Representative compounds have been screened for their CNS activity viz., behavioural, analgesic, anticonvulsant and antireserpine. 8-Chloro-2-(4'-fluorophenyl)-4-phenyl-3H-1,5-benzodiazepinium monoperchlorate has shown pronounced antireserpine activity.
Cell Penetrating Peptides as a Therapeutic Strategy in Chronic Lymphocytic Leukemia (2015)

PP2A is a serine/threonine phosphatase critical to a number of physiological and developmental processes. In this manuscript, we show that a peptide, specifically blocking the caspase- 9/PP2A interaction, DPT-C9h, induces apoptosis in primary tumour B cells isolated from peripheral blood mononuclear cells or bone marrow of chronic lymphocytic leukemia (CLL) patients, but not on B cells obtained from healthy donors (HD). Moreover, in both CLL patients and HD, DPT-C9h does not induce apoptosis on T- and NKcells and monocytes. Our results strongly suggest that DPT-C9h peptide has tumour specificity and that caspase-9/PP2Ac interaction constitutes a novel therapeutic approach for the treatment in CLL patients.
Technique: open lumbar decompression and fusion with the Excelsius GPS robot (2018)

The Excelsius GPS (Globus Medical, Inc.) was approved by the FDA in 2017. This novel robot allows for real-time intraoperative imaging, registration, and direct screw insertion through a rigid external arm-without the need for interspinous clamps or K-wires. The authors present one of the first operative cases utilizing the Excelsius GPS robotic system in spinal surgery. A 75-year-old man presented with severe lower back pain and left leg radiculopathy. He had previously undergone 3 decompressive surgeries from L3 to L5, with evidence of instability and loss of sagittal balance. Robotic assistance was utilized to perform a revision decompression with instrumented fusion from L3 to S1. The usage of robotic assistance in spinal surgery may be an invaluable resource in minimally invasive cases, minimizing the need for fluoroscopy, or in those with abnormal anatomical landmarks. The video can be found here: https://youtu.be/yVI-sJWf9Iw .
Accelerating Big Integer Arithmetic Using Intel IFMA Extensions (2016)

Intel has recently announced a new set of processor instructions, dubbed AVX512IFMA, that carry out Integer Fused Multiply Accumulate operations. These instructions operate on 512-bit registers and compute eight independent 52-bit unsigned integer multiplications, to generate eight 104-bit products, and accumulate their low/high halves into 64-bit containers. Using these instructions requires that inputs are converted to (redundant form) radix 252, and outputs are converted to the desired representation. This paper demonstrates several techniques for leveraging the AVX512IFMA instructions in order to speed up big-integer multiplications. Although processors that support AVX512IFMA are not yet available at the time this paper is written, we show how currently available public tools can be used for estimating their potential performance benefits. For example, based on these tools, we expect a 2x speedup for 1024-bit integer multiplication, over the best currently available method.
An Improved Procedure for the Cyanation of Aryl Triflates: A Convenient Synthesis of 6-Cyano-1,2,3,4-Tetrahydroisoquinoline (1995)

Abstract A short synthesis of 6-cyano-1,2,3,4-tetrahydroisoquinoline is presented. The key step is an improved method of aryl triflate cyanation employing zinc(II)cyanide as the cyanide source.
Introduction to the Issue on Game Theory in Signal Processing (2012)

The ten papers in this special issue focus on game theoretic methods in signal processing and communications research.
An empirical BSSRDF model (2009)

We present a new model of the homogeneous BSSRDF based on large-scale simulations. Our model captures the appearance of materials that are not accurately represented using existing single scattering models or multiple isotropic scattering models (e.g. the diffusion approximation). We use an analytic function to model the 2D hemispherical distribution of exitant light at a point on the surface, and a table of parameter values of this function computed at uniformly sampled locations over the remaining dimensions of the BSSRDF domain. This analytic function is expressed in elliptic coordinates and has six parameters which vary smoothly with surface position, incident angle, and the underlying optical properties of the material (albedo, mean free path length, phase function and the relative index of refraction). Our model agrees well with measured data, and is compact, requiring only 250MB to represent the full spatial- and angular-distribution of light across a wide spectrum of materials. In practice, rendering a single material requires only about 100KB to represent the BSSRDF.
A Scatterer Localization Method Using Large-Scale Antenna Array Systems (2022)

As ultra-massive multiple-input multiple-output (UM-MIMO) has emerged as a key technology for millimeter-wave and terahertz communications, the spherical wave propagation should be considered for channel modeling. Therefore, it is critical to identify the locations and evolving behaviors of scatterers, i.e., the sources of the spherical wavefronts. In this contribution, a novel space-alternating generalized expectation-maximization (SAGE) based scatterer localization algorithm is proposed, where a large-scale antenna array is divided into multiple sub-arrays. Due to the decreased aperture of each sub-array, plane wave assumption can be applied to estimate the angles of departure/arrival, delays and amplitudes of multipath components (MPCs). Based on the angle variations of MPCs observed at different sub-arrays, the corresponding scatterers can be located. The proposed algorithm is verified in a simulation using a large-scale uniform circular array (UCA) system. Moreover, we apply this algorithm to an indoor measurement campaign conducted at 27-29 GHz in a hall scenario. Dominant scatterers are identified, which can be used for the development of further geometry-based stochastic channel models.
Antimitotic Sulfonamides Inhibit Microtubule Assembly Dynamics and Cancer Cell Proliferation (2006)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionAntimitotic Sulfonamides Inhibit Microtubule Assembly Dynamics and Cancer Cell ProliferationRenu Mohan, Mithu Banerjee, Anasuya Ray, Tapas Manna, Leslie Wilson, Takashi Owa, Bhabatarak Bhattacharyya, and Dulal PandaCite this: Biochemistry 2006, 45, 30, 9362Publication Date (Web):July 6, 2006Publication History Published online6 July 2006Published inissue 1 August 2006https://pubs.acs.org/doi/10.1021/bi0680173https://doi.org/10.1021/bi0680173correctionACS PublicationsCopyright © 2006 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views316Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (5 KB) Get e-Alertsclose Get e-Alerts
An efficient procedure for calibration of scanning phased antennas by means of near field planar scanner (2004)

The paper present an easy and efficient procedure for the calibration of scanning phased antennas by means of a near field planar scanner. The main steps of the procedure - modeling of the antenna architecture, near-field data transformation and phase error corrections - are described. Measurement results, obtained by the proposed procedure, are also presented. The paper concludes with some discussions about the practical application and accuracy of the algorithm.
A Mild, One‐Pot Synthesis of Disubstituted Benzimidazoles from 2‐Nitroanilines. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Spectroscopic investigation of redox and acidic properties of Co-substituted aluminophosphate CoAPO-11 (2018)

Acid sites in Co-substituted aluminophosphate CoAPO-11 and its redox properties have been investigated using UV-VIS and IR spectroscopy. The acquired data revealed the absence of the bridged OH groups as a common feature of MII-containing aluminophosphates. The behavior of Co2+/Co3+ couple in redox reactions was very different from that characteristic of supported cobalt ions.
An RNA-Based Vaccine Platform for Use against Mycobacterium tuberculosis (2023)

<i>Mycobacterium tuberculosis</i> (M.tb), a bacterial pathogen that causes tuberculosis disease (TB), exerts an extensive burden on global health. The complex nature of M.tb, coupled with different TB disease stages, has made identifying immune correlates of protection challenging and subsequently slowing vaccine candidate progress. In this work, we leveraged two delivery platforms as prophylactic vaccines to assess immunity and subsequent efficacy against low-dose and ultra-low-dose aerosol challenges with M.tb H37Rv in C57BL/6 mice. Our second-generation TB vaccine candidate ID91 was produced as a fusion protein formulated with a synthetic TLR4 agonist (glucopyranosyl lipid adjuvant in a stable emulsion) or as a novel replicating-RNA (repRNA) formulated in a nanostructured lipid carrier. Protein subunit- and RNA-based vaccines preferentially elicit cellular immune responses to different ID91 epitopes. In a single prophylactic immunization screen, both platforms reduced pulmonary bacterial burden compared to the controls. Excitingly, in prime-boost strategies, the groups that received heterologous RNA-prime, protein-boost or combination immunizations demonstrated the greatest reduction in bacterial burden and a unique humoral and cellular immune response profile. These data are the first to report that repRNA platforms are a viable system for TB vaccines and should be pursued with high-priority M.tb antigens containing CD4+ and CD8+ T-cell epitopes.
Performance analysis of dynamic finite versioning for concurrent transaction and query processing (1992)

In this paper, we analyze the performance of dynamic finite versioning (DFV) schemes for concurrent transaction and query processing, where a finite number of consistent snapshots can be derived for query access. We develop analytical models based on a renewal process approximation to evaluate the performance of DFV using M ≥ 2 snapshots. The storage overhead and obsolescence faced by queries are measured. Simulation is used to validate the analytical models and to evaluate the trade-offs between various starategies for advancing snapshots when M > 2.
Stereocontrol at the Steady State in Radical Cyclizations of Acyclic Dihalides (2002)

The first examples of manipulating stereocontrol solely by reaction topography in radical cyclizations starting from acyclic precursors are reported. The kinetic model for acyclic compound stereoselection is verified experimentally by conducting a series of radical cyclizations of 1,3-dihalo-2-(1-phenyl-3-butynyl)propanes with triphenyltin hydride and measuring the ratios of the products. Monohalide intermediates are observed for the first time, and evidence that bromide- and iodide-substituted radicals have different cyclization rate constants is provided.
Hepatic Bax Inhibitor-1 Inhibits IRE1α and Protects from Obesity-associated Insulin Resistance and Glucose Intolerance (2009)

The unfolded protein response (UPR) or endoplasmic reticulum (ER) stress response is a physiological process enabling cells to cope with altered protein synthesis demands. However, under conditions of obesity, prolonged activation of the UPR has been shown to have deteriorating effects on different metabolic pathways. Here we identify Bax inhibitor-1 (BI-1), an evolutionary conserved ER-membrane protein, as a novel modulator of the obesity-associated alteration of the UPR. BI-1 partially inhibits the UPR by interacting with IRE1alpha and inhibiting IRE1alpha endonuclease activity as seen on the splicing of the transcription factor Xbp-1. Because we observed a down-regulation of BI-1 expression in liver and muscle of genetically obese ob/ob and db/db mice as well as in mice with diet-induced obesity in vivo, we investigated the effect of restoring BI-1 expression on metabolic processes in these mice. Importantly, BI-1 overexpression by adenoviral gene transfer dramatically improved glucose metabolism in both standard diet-fed mice as well as in mice with diet-induced obesity and, critically, reversed hyperglycemia in db/db mice. This improvement in whole body glucose metabolism and insulin sensitivity was due to dramatically reduced gluconeogenesis as shown by reduction of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase expression. Taken together, these results identify BI-1 as a critical regulator of ER stress responses in the development of obesity-associated insulin resistance and provide proof of concept evidence that gene transfer-mediated elevations in hepatic BI-1 may represent a promising approach for the treatment of type 2 diabetes.
The nature and mechanisms of plasticity (2003)

It is now well established that the functional organization of the cerebral cortex is plastic, that is, changes in organization occur throughout life in response to normal as well as abnormal experience. The potential for reorganization has been demonstrated in both sensory and motor areas of adult cortex, either as a consequence of trauma, pathological changes, manipulation of sensory experience, or learning. These changes can only be evaluated with reference to an extensive experimental base that has identified a repeatable representation pattern (e.g. somatotopy, tonotopy, or retinotopy), for which change can be detected. While the scope of changes are often at the edge of our technical capabilities to assess, there are striking examples of significant and rapid change (for reviews, see Sanes & Donoghue, 2000; Buonomano & Merzenich, 1998). There is an overwhelming belief that modifications in cortical organization emerge through changes in synaptic efficacy within the cortex and elsewhere in the nervous system. Further, these changes are have been closely linked to the phenomena called long-term potentiation (LTP) and long-term depression (LTD). This review deals mainly with the changes that have been detected in the motor cortex and their link to synaptic modification. Some of the most convincing evidence that learning and practice influences cortical organization and that learning operates through LTP/D-mediated mechanisms has come through work in the motor cortex. This work is also of profound significance to the medical community because it implies that the impaired or damaged motor cortex can be restructured through appropriate physical rehabilitation schemes or through pharmacological means that alter mechanisms accounting for LTP/D.
High-Robustness and Low-Capacitance Silicon-Controlled Rectifier for High-Speed I/O ESD Protection (2013)

A high-robustness and low-capacitance clamp for on-chip electrostatic discharge (ESD) protection is developed. The low capacitance is obtained by mitigating the capacitance associated with the lightly doped n-well/p-well junction. In addition to minimizing the capacitance, the high ESD robustness is achieved by optimizing independently within the same structure a silicon-controlled rectifier and a diode for the forward and reverse conduction processes, respectively. The new clamp with an area of <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\hbox{50} \times \hbox{10} \ \mu\hbox{m}^{2}$</tex></formula> is able to handle an ESD current in excess of 1.5 A, whereas the capacitance at zero bias is kept at 94 fF.
Ear-EEG detects ictal and interictal abnormalities in focal and generalized epilepsy – A comparison with scalp EEG monitoring (2017)

Ear-EEG is likely to become an important tool in clinical epilepsy monitoring and diagnosis.
Recovery Characteristics of Anomalous Stress-Induced Leakage Current of 5.6 nm Oxide Films (2012)

Anomalous stress-induced leakage current (SILC), which has a much larger current density than average SILC, causes severe bit error in flash memories. To suppress anomalous SILC, detailed evaluations are strongly required. We evaluate the characteristics of anomalous SILC of 5.6 nm oxide films using a fabricated array test pattern, and recovery characteristics are observed. Some characteristics of typical anomalous cells in the time domain are measured, and the recovery characteristics of average and anomalous SILCs are examined. Some of the anomalous cells have random telegraph signals (RTSs) of gate leakage current, which are characterized as discrete and random switching phenomena. The dependence of RTSs on the applied electric field is investigated, and the recovery tendency of anomalous SILC with and without RTSs are also discussed.