gebhart/patrepeval huggingface dataset:
Development of adenovirus immobilization strategies for in situ gene therapy (2008)

The VBABM strategy is a superior method for in situ transduction from biomaterials. This strategy could be adapted for use with a variety of biomaterials as well as viral vectors, and thus may be an alternative method for in vivo regenerative gene therapy.
Mechanical displacement multiplier: 250 &#x03BC;M stable travel range MEMS actuator using frictionless simple compliant structures (2012)

The paper reports a novel MEMS actuator based on mechanical displacement multiplication to achieve a longer travel range MEMS actuator. This architecture employs neither hinges nor gears; but only simple compliant structures. Measurements show displacement reaching up to 250 μm with multiplication factor of 5. This architecture is designed to operate in one direction (Push) although it can be modified to operate in double direction (Push-Pull); accordingly the travel range can be doubled. One order of magnitude multiplication in displacement can be achieved by simple parameters modification and sacrificing die size; using such a new architecture can result in displacement beyond 1 mm while preserving the high yield and productivity. The actuator is realized on an SOI wafer with device thickness 90 μm using DRIE.
Effect of baseline FVC on preservation of lung function with BIBF 1120: Results from the TOMORROW trial (2011)

Background: BIBF 1120 is an inhibitor of tyrosine kinase receptors involved in the progression of lung fibrosis. Methods: The efficacy and safety of 50 mg, 100 mg, 200 mg and 300 mg daily doses of BIBF 1120 were evaluated in 428 patients diagnosed with IPF in a Phase 2 randomized, double-blind placebo (PBO)-controlled trial. Subgroup analyses of the annual rate of decline in forced vital capacity (FVC) by baseline lung function were carried out to evaluate the impact of stage of disease on the effect of BIBF 1120. Results: Baseline FVC was similar in all groups (mean: 2.8 L; 81.3% predicted). The annual rate of decline in FVC was -0.060 L/year with BIBF 1120 300 mg vs -0.190 L/year with PBO (p=0.014; closed-testing multiplicity-corrected: p=0.064). Patients with baseline FVC ≥70% of predicted value showed almost no FVC decline with BIBF 1120 300 mg (-0.010 L/year [n=57] compared with -0.186 L/year in the PBO group [n=61]; p=0.004). However, there were no significant differences in FVC decline in patients with baseline FVC &lt;70% of predicted value (-0.176 L/year with 300 mg [n=27] vs -0.203 L/year with PBO [n=22]; p=0.794). Similarly, lower rates of FVC decline were observed with 300 mg vs PBO in patients with baseline FVC ≥85% (-0.027 L/year [n=30] vs -0.160 [n=31]; p=0.112) and ≥90% (-0.019 L/year [n=23] vs -0.186 [n=25]; p=0.088) of predicted value; however, these findings were based on small sample sizes and the differences did not reach significance. Conclusion: The effects of IPF treatment may be more easily demonstrable in patients with FVC values closer to predicted values.
Supplementary Table 1 from Overall Survival in Malignant Glioma Is Significantly Prolonged by Neurosurgical Delivery of Etoposide and Temozolomide from a Thermo-Responsive Biodegradable Paste (2023)

&lt;p&gt;Supplementary Table&lt;/p&gt;
Electro-optic depolarization switch on y-cut LiNbO3 proton-exchanged channel waveguides (1989)

We report the first electro-optic depolarization (TE guided mode to TM substrate modes) switch on y-cut LiNbO3 proton-exchanged channel waveguides operating at 632.8 nm. Tunability of the waveguide ordinary and extraordinary indices through thermal annealing provides an alternative way to reduce the drive voltage. An extinction ratio of 13.5 dB is achieved with 10 V applied voltage on a switch with 4 μm channel width and 3 mm electrode length. The measured capacitance of the electrode is 4.2 pF, which gives a theoretical modulation bandwidth of 1.5 GHz in a 50 Ω lumped electrode structure.
ChemInform Abstract: Synthesis of Selective Non‐Ca2+‐Mobilizing Inhibitors of D‐myo‐ Inositol 1,4,5‐Trisphosphate 5‐Phosphatase. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An Experimental Comparison of Algebraic Reading Practace and the Solving of Additional Verbal Problems in Tenth Grade Algebra (1941)

The solution of verbal problems in algebra has always presented difficulties to pupils and teachers. Orlie and Hendershot conclude that “the weakest part of classroom instruction is the teaching of verbal problems” (8:147). Haertter says, “High School pupils who study algebra have greater difficulty in the solution of verbal problems than with the study of any other topic of that subject” (6: 166). In a questionnaire submitted by one of the present writers, fifty-three teachers of algebra in the province of Saskatchewan ranked the solution of verbal problems as the most difficult topic in the algebra they taught.
Infraclavicular brachial plexopathy secondary to coracoid osteoid osteoma. (2007)

Coracoid osteoid osteomas are rare. This case report presents two patients with coracoid osteoid osteomas who developed neurologic sequelae of the infraclavicular brachial plexus (namely, musculocutaneous neuropathy in one patient with an anterior lesion, and suprascapular neuropathy in the other patient with a more posterior lesion). The neuropathy was due to soft tissue edema, which surrounded the bony lesion and was apparent on MRI. Surgical resection of the bony lesion in both cases produced excellent outcomes at long-term follow-up.
Efficient and thermally stable blue-emitting Ce3+ doped LaAl(Si6−zAlz)(N10−zOz) (JEM:Ce) phosphors for white LEDs (2017)

La<sub>2</sub>O<sub>3</sub>, LaN, Si<sub>3</sub>N<sub>4</sub>, AlN and CeO<sub>2</sub> have been used as starting materials to synthesize Ce doped LaAl(Si<sub>6−z</sub>Al<sub>z</sub>)(N<sub>10−z</sub>O<sub>z</sub>) (<italic>z</italic> ≈ 1, termed the JEM phase) phosphors, <italic>via</italic> a solid-state reaction method in a gas pressure furnace at a high temperature.
Inorganic nanoparticles as antioxidants (2010)

Reactive oxygen and nitrogen species play a critical role in many degenerative diseases and in aging. Nanomaterials, especially modified fullerenes and cerium oxide nanoparticles, have been shown to effectively protect mammalian cells against damage caused by increased reactive oxygen or nitrogen species, likely through their direct reaction with superoxide radical, since each of these materials has been shown to act as effective superoxide dismutase mimetics in vitro. The redox ability of rare earth oxides (ceria, lanthanides, etc) has been used in a wide range of applications such as three way catalysis, oxygen buffer systems, sensors and corrosion prevention. While these nanostructures have been widely used in many inorganic applications, their role in biology as catalyst is not explored. We have recently utilized nano cerium oxide's potential use in the treatment of disorders caused by the reactive oxygen intermediates (ROI). This presentation will provide a brief overview of the applications of nanoceria in treatment of disorders caused by ROS. The role of size and stability of ceria nanoparticles in toxicity analysis has also been explored. For various practical applications, synthesis of biocompatible and stable suspensions of nanoceria is essential. It was found that the redox kinetics of regenerative ceria nanoparticles can be controlled with the type of medium and their implications in nanobiomedicine is presented.
Global Phosphotyrosine Proteomics Identifies PKCδ as a Marker of Responsiveness to Src Inhibition in Colorectal Cancer (2013)

Sensitive and specific biomarkers of protein kinase inhibition can be leveraged to accelerate drug development studies in oncology by associating early molecular responses with target inhibition. In this study, we utilized unbiased shotgun phosphotyrosine (pY) proteomics to discover novel biomarkers of response to dasatinib, a small molecule Src-selective inhibitor, in preclinical models of colorectal cancer (CRC). We performed unbiased mass spectrometry shotgun pY proteomics to reveal the pY proteome of cultured HCT-116 colonic carcinoma cells, and then extended this analysis to HCT-116 xenograft tumors to identify pY biomarkers of dasatinib-responsiveness in vivo. Major dasatinib-responsive pY sites in xenograft tumors included sites on delta-type protein kinase C (PKCδ), CUB-domain-containing protein 1 (CDCP1), Type-II SH2-domain-containing inositol 5-phosphatase (SHIP2), and receptor protein-tyrosine phosphatase alpha (RPTPα). The pY313 site PKCδ was further supported as a relevant biomarker of dasatinib-mediated Src inhibition in HCT-116 xenografts by immunohistochemistry and immunoblotting with a phosphospecific antibody. Reduction of PKCδ pY313 was further correlated with dasatinib-mediated inhibition of Src and diminished growth as spheroids of a panel of human CRC cell lines. These studies reveal PKCδ pY313 as a promising readout of Src inhibition in CRC and potentially other solid tumors and may reflect responsiveness to dasatinib in a subset of colorectal cancers.
ChemInform Abstract: Dammarane‐Type Glycosides from the Steamed Flower‐Buds of Panax ginseng. (2010)

Abstract The new dammarane‐type glycoside ginsenoside SF (I) is isolated from the steamed flower‐buds of Panax ginseng along with 19 known saponins.
Sonographic diagnosis of a cervical vagal schwannoma (2008)

This case report illustrates the role of high-resolution sonography in the preoperative assessment of a schwannoma of the vagus nerve in the neck. Sonography identified the tumor in the right carotid space and determined its origin from the right vagus nerve, facilitating the surgeon's approach to preserve nerve function.
Recent Developments in Solid Lipid Microparticles for Food Ingredients Delivery (2021)

Health food has become a prominent force in the market place, influencing many food industries to focus on numerous bioactive compounds to reap benefits from its properties. Use of these compounds in food matrices has several limitations. Most of the food bio-additives are sensitive compounds that may quickly decompose in both food and within the gastrointestinal tract. Since most of these bioactives are highly or partially lipophilic molecules, they possess very low water solubility and insufficient dispersibility, leading to poor bioavailability. Thus, various methods of microencapsulation of large number of food bioactives have been studied. For encapsulation of hydrophobic compounds several lipid carriers and lipid platforms have been studied, including emulsions, microemulsions, micelles, liposomes, and lipid nano- and microparticles. Solid lipid particles (SLP) are a promising delivery system, can both deliver bioactive compounds, reduce their degradation, and permit slow and sustained release. Solid lipid particles have important advantages compared to other polymer carriers in light of their simple production technology, including scale up ability, higher loading capacity, extremely high biocompatibility, and usually low cost. This delivery system provides improved stability, solubility in various matrixes, bioavailability, and targeting properties. This article reviews recent studies on microencapsulation of selected bioactive food ingredients in solid lipid-based carriers from a point of view of production methods, characteristics of obtained particles, loading capability, stability, and release profile.
Nanoimprinting Using Ni Molds Prepared from Highly Ordered Anodic Porous Alumina Templates (2006)

Large-sized Ni molds having patterns of less than 100 nm period were fabricated from naturally ordered anodic porous alumina as a template. The obtained Ni molds could be applied to the nanoimprinting of photopolymerized polymers. An ordered hole array structure of polymer was generated by nanoimprinting using the Ni molds. The hole period of the polymer nanohole arrays could be controlled by changing the geometrical structure of the anodic porous alumina template.
Slit2‐Robo1 regulates control of SDF‐1 induced T cell adhesion in NOD mice (2009)

We have recently reported that SDF‐1/CXCL12 paradoxically attenuates diabetogenic NOD/LtJ T cell firm adhesion to TNF‐α stimulated islet microvascular endothelial cells; however, the reason for this response is unknown. Here we report that NOD/LtJ T cell adhesion responses to SDF‐1 are modulated by Slit2‐Robo1 signaling, with increased Slit2‐Robo1 binding causing reduced adhesion in response to SDF‐1. We investigated whether differing basal levels of Slit2 or Robo1 are responsible for the diametric effects of SDF‐1 concentration on adhesion of NOD/LtJ and C57BL/6J mouse T cells. Western blot and flow cytometry analysis shows that Robo1 expression is significantly elevated in NOD/LtJ mice compared to C57BL/6J mice. Blocking Slit2‐Robo1 interactions with an anti‐Robo1 antibody in parallel plate flow chamber adhesion assays shifted the effect of SDF‐1 from chemorepulsion to chemoattraction clearly implicating Robo‐1 in regulating SDF‐1 adhesion responses. These results demonstrate that autoimmune diabetogenic T cell recruitment and adhesion is highly dependent on Robo1 expression and identifies a previously unknown mechanism of regulating chemokine dependent leukocyte recruitment.
Delay spread and time dispersion estimation for adaptive OFDM systems (2006)

Time dispersion is one of the most important characteristics of the wireless channel. The knowledge about the time dispersion of a channel can be used for designing better systems which can adapt themselves to the changing nature of the transmission medium. In this paper, algorithms for estimating the time dispersion (frequency selectivity) of the channel, which use the frequency domain channel estimates or the frequency domain received signal, are proposed. The proposed algorithms first estimate the power delay profile (PDP) from which the two important dispersion parameters, namely root-mean-squared (RMS) delay spread and maximum excess delay of the channel, are estimated. It is shown that synchronization errors bias the performance of the estimators based on the channel correlation, and this bias is removed by obtaining the PDP using the magnitude of the channel estimates. The performances of the proposed algorithms are evaluated using computer simulations
AN OPTOFLUIDIC BEAM SPLITTER WITH LARGE TUNING ANGLE VIA CONTROL OF FLOW RATE (2009)

This paper reports a phenomenon of light in which light is split by three flow streams with a large tunable angle up to 30o. The core flow stream with lower refrac-tive index is sandwiched by the cladding flow streams with higher refractive index. The miscible fluids creates a refractive index gradient in the microchannel that split an incident beam into two propagating paths. The angle is controlled by the compo-sition of the fluids and the flow rates. The optofluidic splitter has high potential ap-plications in biomedical and chemical solution measurement and detection.
Epitope Mapping of a Function-blocking β1 Integrin Antibody by Phage Display (1998)

Integrins are a major class of cell surface receptors involved in cell-cell and cell-matrix adhesion and communication. Ha2/11 is a function-blocking anti-rat beta 1 integrin hamster IgM that should be a useful reagent for understanding beta 1 integrin function. We demonstrate that Ha2/11 cross reacts with human, Xenopus, and Drosophila beta 1 integrins, and use phage display to map the epitope for Ha2/11 to residues within the sequence LRSGEPQTF which lies 18 amino acids proximal to the putative I domain in beta 1 integrins. Monoclonal antibody mapping experiments, mutational analyses, and direct binding assays have implicated integrin I domains in both cation and ligand binding. Our data therefore suggest that Ha2/11 blocks beta 1 integrin function by interfering with I domain-mediated ligand binding.
Using BioBots for standardizing the 3D bioprinting of liver bioink (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Photonic Crystals (2015)

Electronics and photonics share many attributes. In particular, both these areas of technology deal with information, so their size is not determined by some physical quantity that has to be received, stored, manipulated, and transmitted. Both electronics and photonics can therefore potentially benefit from miniaturization, which leads to lower cost of production, transportation, installation, and maintenance. In comparison to electronics, however, photonic devices are significantly more challenging to miniaturize. The reason is that photons, being bosons, interact only weakly with matter and are therefore difficult to store and manipulate. Even optical detectors require relatively large volumes to effectively absorb light, and larger still are other types of photonic devices that change some aspect of the photons without absorbing them.
N-Acyl l-Homocysteine Thiolactones Are Potent and Stable Synthetic Modulators of the RhlR Quorum Sensing Receptor in Pseudomonas aeruginosa (2019)

The RhlR quorum sensing (QS) receptor in the pathogen Pseudomonas aeruginosa plays a prominent role in infection, and both antagonism and agonism of RhlR have been shown to negatively regulate important virulence phenotypes. Non-native lactone ligands are known to modulate RhlR activity, but their utility as chemical probes is relatively limited due to hydrolytic instability. Herein, we report our design and biological evaluation of a suite of hybrid AHL analogs with structures merging (1) features of reported lead RhlR ligands and (2) head groups with improved hydrolytic stabilities. The most promising compounds identified were N-acyl l-homocysteine thiolactones, which displayed enhanced stabilities relative to lactones. Moreover, they were highly selective for RhlR over another key QS receptor in P. aeruginosa, LasR. These compounds are among the most potent RhlR modulators known and represent robust chemical tools to dissect the complex roles of RhlR in the P. aeruginosa QS circuitry.
Hippocampal Gene Expression Analysis Highlights Ly6a/Sca-1 as Candidate Gene for Previously Mapped Novelty Induced Behaviors in Mice (2011)

In this study, we show that the covariance between behavior and gene expression in the brain can help further unravel the determinants of neurobehavioral traits. Previously, a QTL for novelty induced motor activity levels was identified on murine chromosome 15 using consomic strains. With the goal of narrowing down the linked region and possibly identifying the gene underlying the quantitative trait, gene expression data from this F(2)-population was collected and used for expression QTL analysis. While genetic variation in these mice was limited to chromosome 15, eQTL analysis of gene expression showed strong cis-effects as well as trans-effects elsewhere in the genome. Using weighted gene co-expression network analysis, we were able to identify modules of co-expressed genes related to novelty induced motor activity levels. In eQTL analyses, the expression of Ly6a (a.k.a. Sca-1) was found to be cis-regulated by chromosome 15. Ly6a also surfaced in a group of genes resulting from the network analysis that was correlated with behavior. Behavioral analysis of Ly6a knock-out mice revealed reduced novelty induced motor activity levels when compared to wild type controls, confirming functional importance of Ly6a in this behavior, possibly through regulating other genes in a pathway. This study shows that gene expression profiling can be used to narrow down a previously identified behavioral QTL in mice, providing support for Ly6a as a candidate gene for functional involvement in novelty responsiveness.
Program Segmentation for TV Videos (2005)

A number of video browsing and retrieval systems use a hierarchical video structure (video, scene, group, shot, and keyframe) as the basis for information organization and access. However, this structure cannot represent and manage efficiently the videos recorded from TV channels, since TV videos are usually very long and consist of many scenes. More importantly, people tend to watch these videos by program and not by scenes or shots. To address this problem, we insert a new structure level, referred to as program, between the video and scene level to enhance the hierarchical structure representation. An automatic program segmentation algorithm is presented for constructing the video structure in this paper. Experimental results based on real-world TV videos demonstrate the effectiveness of the proposed approach.
Modeling and Analysis of Loading Effect in Leakage of Nano-Scaled Bulk-CMOS Logic Circuits (2007)

In nanometer scaled CMOS devices significant increase in the subthreshold, the gate and the reverse biased junction band-to-band-tunneling (BTBT) leakage, results in the large increase of total leakage power in a logic circuit. Leakage components interact with each other in device level (through device geometry, doping profile) and also in the circuit level (through node voltages). Due to the circuit level interaction of the different leakage components, the leakage of a logic gate strongly depends on the circuit topology i.e. number and nature of the other logic gates connected to its input and output. In this paper, for the first time, we have analyzed loading effect on leakage and proposed a method to accurately estimate the total leakage in a logic circuit, from its logic level description considering the impact of loading and transistor stacking.
Supplementary information from Balancing Efficacy and Safety of an Anti-DLL4 Antibody through Pharmacokinetic Modulation (2023)

&lt;p&gt;Supplemental Methods: including HUVEC fibrin gel bead assay, Production of anti-DLL4 F(ab')2, Mouse neonatal retina assay, Xenograft tumor models, Histological analysis of mouse liver, PK assay methods, and Anti-therapeutic antibody assay method. Table S1: PK parameters of anti-DLL4 IgG1 and F(ab')2 in mouse. Table S2: PK parameters for anti-DLL4 IgG1 and F(ab')2 in rat and money. Table S3: Summary of incidence of skin neoplasms in rats treated with anti-DLL4 IgG1 or anti-DLL4 F(ab')2. Figure S1: Generating and characterizing low affinity anti-DLL4 antibodies. Figure S2: Characterization of anti-DLL4 F(ab')2 using HUVEC bead sprouting assay. Figure S3: PK profile of anti-DLL4 IgG1 and F(ab')2 in rat toxicity studies. Figure S4. Mitigation of liver toxicity in mice with anti-DLL4 F(ab')2. Figure S5. Novel toxicities identified with anti-DLL4 F(ab')2 in rats.&lt;/p&gt;
Learning Monocular Face Reconstruction using Multi-View Supervision (2020)

We present a method to reconstruct faces from a single portrait image. While traditional face reconstruction methods fit low-dimensional 3D morphable models to images, we train a deep network to regress depth from a single image directly. We do so by combining supervised losses on synthetic data with indirect supervision on real data using a novel multi-view photo-consistency loss. Furthermore, we regularize the depth estimation using a 3D morphable model (3DMM). We demonstrate that this leads to results that preserve facial features, capture facial geometry that goes beyond 3DMMs, and is also robust to viewpoint conditions. We evaluate our method on various datasets and via ablation studies, and demonstrate that it outperforms previous work significantly.