gebhart/patrepeval huggingface dataset:
IS5 inserts upstream of the master motility operon flhDC in a quasi-Lamarckian way (2011)

Mutation rates may be influenced by the environment. Here, we demonstrate that insertion sequence IS5 in Escherichia coli inserts into the upstream region of the flhDC operon in a manner that depends on whether the environment permits motility; this operon encodes the master regulator of cell motility, FlhDC, and the IS5 insertion increases motility. IS5 inserts upstream of flhD(+) when cells are grown on soft-agar plates that permit swimming motility, but does not insert upstream of this locus on hard-agar plates that do not permit swimming motility or in planktonic cultures. Furthermore, there was only one IS5 insertion event on soft-agar plates, indicating insertion of IS5 into flhDC is not due to general elevated IS5 transposition throughout the whole genome. We also show that the highly motile cells with IS5 upstream of flhD(+) have greater biofilm formation, although there is a growth cost due to the energetic burden of the enhanced motility as these highly motile cells have a lower yield in rich medium and reduced growth rate. Functional flagella are required for IS5 insertion upstream of flhD(+) as there was no IS5 insertion upstream of flhD(+) for flhD, flgK and motA mutants, and the mutation is stable. Additionally, the IS5 mutation occurs during biofilm formation, which creates genetic and phenotypic diversity. Hence, the cells appear to 'sense' whether motility is feasible before a sub-population undergoes a mutation to become hypermotile; this sensing appears related to the master transcription regulator, FlhDC.
PSO-based power control of two series resonant inverters sharing resonant capacitor for domestic induction heating (2013)

Current technology for domestic induction heating requires to deliver a wide range of power (50 W-3.5 kW) to the vessel to be heated. In addition to this, the considered power control strategy must ensure high reachability and compliance with some constraints. This work is focused on applying the Phase Shift Control (PSC) modulation to control the power delivered to two induction loads. The considered topology is based on two half-bridge resonant inverters that control two domestic induction heating loads sharing a single resonant capacitor. The two outputs to be controlled are coupled, leading to a harder control problem. Therefore, a Particle Swarm Optimization (PSO) algorithm based on the gradient information is proposed to perform the power control by considering the PSC modulation. Finally, simulations are discussed and verified with some experimental results obtained in a prototype induction heating system.
ChemInform Abstract: POLYFLUOROALKYL COMPOUNDS OF SILICON PART 10, FURTHER SILANES CONTAINING THE BIS(TRIFLUOROMETHYL)AMINO‐GROUP (1974)

Abstract Die photochemische Reaktion der Silane (I) mit dem fluorierten Aminoäthylen (II) führt zu den Äthylensilanen (III).
Discordance Between Cerebral Oxygen and Glucose Metabolism, and Hemodynamics in a Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike Episode Patient (2001)

A patient with mitochondrial encephalomyopathy, lactic acidosis, and strokelike episode (MELAS) syndrome underwent serial measurement of cerebral blood flow with xenon computed tomography (Xe-CBF) while presenting with strokelike episodes accompanied by a cerebral lesion. He underwent positron emission tomography (PET) measurement of the regional cerebral blood flow (PET-CBF), metabolic rate of oxygen (CMRO2), and glucose (CMRGlu) after his symptoms and lesion disappeared. During the symptomatic period, Xe-CBF and the Xe-CBF response to acetazolamide loading were well preserved both in and outside the low-density lesion. In the PET study, decreased CMRO2 and increased PET-CBF and CMRGlu were noted in the entire brain. The strokelike episodes of patients with MELAS are more likely attributed to the failure of oxygen metabolism than to a vascular accident.
FIFOrder MicroArchitecture: Ready-Aware Instruction Scheduling for OoO Processors (2019)

The number of instructions a processor's instruction queue can examine (depth) and the number it can issue together (width) determine its ability to take advantage of the ILP in an application. Unfortunately, increasing either the width or depth of the instruction queue is very costly due to the content-addressable logic needed to wakeup and select instructions out-of-order. This work makes the observation that a large number of instructions have both operands ready at dispatch, and therefore do not benefit from out-of-order scheduling. We leverage this to place such ready-at-dispatch instructions in separate, simpler, in-order FIFO queues for scheduling. With such additional queues, we can reduce the size and width of the expensive out-of-order instruction queue, without reducing the processor's overall issue width and depth. Our design, FIFOrder, is able to steer more than 60% of instructions to the cheaper FIFO queues, providing a 50% energy savings over a traditional out-of-order instruction queue design, while delivering 8% higher performance.
Thermische Desoxygenierung von syn‐15,16‐Dioxo‐1,6:8,13‐bismethano[14]annulen zum Pyren‐Isomer Dicyclohepta[cd,gh]pentalen (Azuleno[2,1,8‐ija]azulen) (1984)

Eine einzigartige Reaktion findet bei der Pyrolyse des Diketons 1 statt. Die Bildung des Pyren‐Isomers 2 (60%) ist kaum anders zu erklären als über ein 1,2‐Dioxetan; diese Reaktion wäre damit die Umkehr der oxidativen Spaltung elektronenreicher Doppelbindungen mit Singulett‐Sauerstoff. Durch den erwarteten schrittweisen Zerfall von 1 über ein Norcaradienon‐Derivat erhält man außerdem 30% Anthracen. magnified image
Observation of Adsorption Phenomena of Dibutyl Phthalate Molecules on Si Surface Using Quartz Crystal Microbalance Method (2004)

The adsorption phenomena of dibutyl phthalate (DBP) molecules on the Si surface were observed in detail using a highly sensitive quartz crystal microbalance (QCM) and a new method involving a sliding chamber system. As a result of the precise observation of the adsorption phenomena and an accurate decomposition analysis, the typical Langmuir adsorption phenomenon with a time constant of 350 s was observed following the rapid adsorption phenomenon that occurs within the first 10 s and the next adsorption phenomenon of increasing linearly. After almost reaching the adsorption equilibrium amount, another Langmuir adsorption phenomena for a time constant of 3000 s was also observed; the Langmuir adsorption phenomenon for a time constant of 350 s seems to be that of an isolated admolecule whereas that for 3000 s seems to be one where admolecule cohere by mutual migration on a surface.
Keratoconjunctivitis by confocal microscopy after topical cyclosporine. (2012)

AIM: To describe the observations obtained by confocal microscopy concerning corneal stromal structure in the process of adenoviral epidemic keratoconjunctivitis, from the onset of the disease up to 20 weeks of follow-up, after topical cyclosporine. METHODS: A 16-years-old boy has developed subepithelial infiltrates and an epidemic keratoconjunctivitis from adenovirus in both eyes. Clinical case was analyzed by confocal microscopy (40x mode, Nidek ConfoScan 4) before and after administration of topical cyclosporine. RESULTS: Two weeks after the onset of the symptoms, corneal stroma showed the presence of cells with highly reflective area. These cells, comparable to keratocytes, had a typical fusiform shape and assumed a particular rosette disposition, never highlighted in the literature. Hyperreflective areas disappeared in both eyes after administration of topical cyclosporine 1% for 30 days. This outcome was also confirmed after five months. CONCLUSION: The confocal microscopy performed on the surface of the stroma before and after treatment with cyclosporine suggests the presence of a localized immune activation in subepithelial layer.
Supplementary Figures 1-3 from <i>Aurora A</i> Is a Repressed Effector Target of the Chromatin Remodeling Protein INI1/hSNF5 Required for Rhabdoid Tumor Cell Survival (2023)

Supplementary Figures 1-3 from &lt;i&gt;Aurora A&lt;/i&gt; Is a Repressed Effector Target of the Chromatin Remodeling Protein INI1/hSNF5 Required for Rhabdoid Tumor Cell Survival
Why green fluorescent fusion proteins have not been observed in the vacuoles of higher plants (2003)

Green fluorescent protein (GFP) makes it possible for organelles and protein transport pathways to be visualized in living cells. However, GFP fluorescence has not yet been observed in the vacuoles of any organs of higher plants. We found that the fluorescence of a vacuole-targeted GFP was stably observed in the vacuoles of transgenic Arabidopsis plants under dark conditions, and that the fluorescence rapidly disappeared under light conditions. The vacuolar GFP was rapidly degraded within 1 h in the light, especially blue light. An inhibitor of vacuolar type H+-ATPase, concanamycin A, and an inhibitor of papain-type cysteine proteinase, E-64d, abolished both the light-dependent disappearance of GFP fluorescence and GFP degradation in the vacuoles. An in vitro assay showed that bacterially expressed GFP was degraded by extracts of Arabidopsis cultured-cell protoplasts at an acidic pH in the light. These results suggest that blue light induced a conformational change in GFP, and the resulting GFP in the vacuole was easily degraded by vacuolar papain-type cysteine proteinase(s) under the acidic pH. The light-dependent degradation accounts for the failure to observe GFP fluorescence in the vacuoles of plant organs. Our results show that stable GFP-fluoresced vacuoles are achieved by transferring the plants from the light into the dark before inspection with a fluorescent microscope. This might eliminate a large hurdle in studies of the vacuolar-targeting machinery and the organ- and stage-specific differentiation of endomembrane systems in plants.
Two Families of Algorithms to Film Sport Events with Flying Robots (2013)

In this paper, we introduce two families of distributed algorithms to control the movement of groups of flying robots that are monitoring an event by moving over the field where the event takes place, while optimizing some specific objective. In order to show the effectiveness of our algorithms, we formulate the Sport Event Filming (SEF) problem. The objective of the problem is to maximize the satisfaction of event viewers while minimizing the distance traveled by the camera-drones. We propose two families of solutions to solve the dynamic version of the problem, where the flying robots do not have any knowledge of the input sequence and move in reaction to the movements of the protagonists of the event. The first family (Nearest Neighbor)is based on a technique used in robotic systems, whereas the second family (Ball Movement Interception) is designed based on specific characteristics of the SEF problem. We present extensive simulation results for both families in terms of average viewer satisfaction and travelled distance for the flying robots, when several parameters vary.
Genetic and epigenetic inactivation of LTF gene at 3p21.3 in lung cancers (2005)

Allelic loss on the short arm of chromosome 3 is one of the most common events in the pathogenesis of lung cancer. The lactotransferrin gene (LTF, also referred to as the lactoferrin gene, LF) is located at 3p21.3 common eliminated region 1, which is frequently deleted in lung and other cancers. The expression of the LTF gene was absent in 16 (59%) of 27 small cell lung cancer cell lines, 33 (77%) of 43 nonsmall-cell lung cancer (NSCLC) cell lines and 7 (54%) of 13 primary NSCLC, while LTF mRNA was overexpressed in 3 (7%) of 43 NSCLC cell lines. Its expression was restored by treatment with 5-aza-2'-deoxycytidine (5-aza-dC), trichostatin A (TSA) or a combination of both in a subset of lung cancer cell lines without LTF expression. In addition, we found 8 different types of nucleotide substitutions and one frameshift mutation. These results indicate that the LTF gene is inactivated by genetic and epigenetic mechanisms in lung cancer.
High-k Gate Stack Engineering Towards Meeting Low Standby Power and High Performance Targets (2006)

Abstract not Available.
Bestimmung linksventrikulärer Funktionsparameter: Vergleich von 16-Zeilen-Mehrschicht-CT mit der MR-Tomographie (2004)

For left ventricular functional parameters, MSCT of the heart with retrospective ECG-gating showed a high correlation with MRI, which has an important implication when using MSCT for non-invasive cardiac imaging. Despite the high correlation, overestimation of EDV, EVS, SV, and MM with MSCT has to be taken into account when applying this technology in clinical practice. EF was not significantly different between both modalities.
The Mighty Mice Prove Pluripotency for iPSCs (2010)

By injecting induced pluripotent stem cells (iPSCs) into tetraploid blastocysts to generate live pups, two groups in China demonstrated that the injected cells are as pluripotent as embryonic stem cells, i.e. capable of giving rise to every cell in the newborn mice. This achievement validates iPS technology for regenerative medicine.
Clinical Impact of a Novel MicroRNA Chemo-Sensitivity Predictor in Gastrooesophageal Cancer (2016)

The miRNA profile predictive for sensitivity to cisplatin, epirubicine and capecitabine was shown to be independently associated with OS and DSS in patients with gastrooesophageal cancer.
Symmetry analysis and Monte Carlo study of a frustrated antiferromagnetic planar (XY) model in two dimensions (1986)

The antiferromagnetic planar (XY) model on a triangular lattice is investigated using group-theoretical symmetry arguments combined with extensive Monte Carlo simulations and a detailed finite-size-scaling analysis. This approach allows for a systematic exploration of all possible symmetry-breaking transitions and their associated critical behavior. The entire magnetic-field--versus--temperature phase diagram is deduced. A rich class of possible new critical phenomena is obtained, including the introduction of a new multicritical point describing the confluence of the Ising and Kosterlitz-Thouless universality classes. The existence of the critical point is associated with a domain-wall-induced vortex-antivortex--unbinding transition.
Polarimeter-Based Optical Spectrum Analyzer (2008)

We propose and experimentally demonstrate a novel polarimeter-based optical spectrum analyzer. The high-speed and high-resolution nature enables measurement of fast swept sources beyond 100-KHz. A unique 3-D display shows the spectra of a fast-scanning source.
The structure, modelling and dynamics of 2,7-diisopropoxy-1,8-diarylnaphthalenes (2002)

2,7-Diisopropoxy-1,8-dibromonaphthalene 5 was prepared in two steps from 2,7-dihydroxynaphthalene and was coupled under Suzuki cross-coupling conditions with boronic acids 9 and 10 to provide the corresponding 1,8-diarylnaphthalene systems 12a and 13a respectively. In contrast, attempted coupling of dibromide 5 with o-tolylboronic acid 11 proved unrewarding. Single crystal X-ray structure determination of compounds 12a and 13a showed that both structures possessed a high degree of structural deformation due to high internal steric repulsions between the 1,8-diaryl rings and their substituents. Dynamic 1H NMR experiments showed that these two systems possessed very slow phenyl–naphthalene bond rotation (ca. 2 s−1), corresponding to rotation barriers (ΔG*) of 16–18 kcal mol−1. Molecular modelling predicts that such systems have approximately similar rotation barriers and that in order to completely prevent phenyl–naphthalene bond rotation, an ortho-phenyl substituent is required, with a barrier to rotation of ca. 40 kcal mol−1.
Osteoclasts are important for bone angiogenesis (2009)

Increased osteoclastogenesis and angiogenesis occur in physiologic and pathologic conditions. However, it is unclear if or how these processes are linked. To test the hypothesis that osteoclasts stimulate angiogenesis, we modulated osteoclast formation in fetal mouse metatarsal explants or in adult mice and determined the effect on angiogenesis. Suppression of osteoclast formation with osteoprotegerin dose-dependently inhibited angiogenesis and osteoclastogenesis in metatarsal explants. Conversely, treatment with parathyroid hormone related protein (PTHrP) increased explant angiogenesis, which was completely blocked by osteoprotegerin. Further, treatment of mice with receptor activator of nuclear factor-kappaB ligand (RANKL) or PTHrP in vivo increased calvarial vessel density and osteoclast number. We next determined whether matrix metalloproteinase-9 (MMP-9), an angiogenic factor predominantly produced by osteoclasts in bone, was important for osteoclast-stimulated angiogenesis. The pro-angiogenic effects of PTHrP or RANKL were absent in metatarsal explants or calvaria in vivo, respectively, from Mmp9(-/-) mice, demonstrating the importance of MMP-9 for osteoclast-stimulated angiogenesis. Lack of MMP-9 decreased osteoclast numbers and abrogated angiogenesis in response to PTHrP or RANKL in explants and in vivo but did not decrease osteoclast differentiation in vitro. Thus, MMP-9 modulates osteoclast-stimulated angiogenesis primarily by affecting osteoclasts, most probably by previously reported migratory effects on osteoclasts. These results clearly demonstrate that osteoclasts stimulate angiogenesis in vivo through MMP-9.
Processing Characteristics of TEEK Polyimide Foam (2004)

High performance polymeric foams have experienced a growing demand in aerospace applications such as cryogenic insulation, flame-retardant panels and structural sub-components. The Next Generation Launch Technology (NGLT) program requires foams capable of retaining their structural integrity while providing insulating capabilities in a liquid hydrogen environment. NASA Langley Research Center (LaRC) and Unitika Ltd co-developed a polyimide foam processed from a fine powder of salt-like foaming precursor isolated from solution via solvent evaporation. This paper reports the foaming characteristics of this precursor based on rheometric, calorimetric, thermogravimetric and chromatographic characterization methods. The degree of foaming varied significantly as a function of process heating rate and hold temperatures. Results from the battery of measuring techniques employed afford a complete picture of the foaming and curing mechanism for the subject polyimide foam.
The Standard Instrument Space Libraries : Demonstrating the Power of ISEE (1995)

: In this demonstration, some of the design features of the first instrument space libraries accompanying the recently released Intuitive Sound Editing Environment 1.1 (ISEE) for Macintosh, a synthesis model-independent, perceptually-based synthesizer editor, will be shown. The standard instrument space libraries included with this release provide a transparent use of different synthesis models and different synthesis platforms to musicians and composers. Introduction ISEE is a perceptually-based synthesis editor in which timbre characteristics are controlled by means of instrument spaces which can be hierarchically organized into library documents according to their refinement and perceptual categorisation [Vertegaal and Bonis]. Each instrument space is made up by four timbral parameters. The first two of these parameters control the frequency contents (spectral envelope) of the sound and the last two to its development in time (temporal envelope): the Overtones parameter controls t...
Instruction set mapping for performance optimization (1993)

Performance optimization is the primary design goal in most digital signal processing (DSP) and numerically intensive applications. The problem of mapping high-level algorithmic descriptions for these applications to specialized instruction sets has only recently begun to receive attention. In fact, the problem of optimizing performance has yet to be addressed directly. This paper introduces a new approach to instruction set mapping (and template matching in general) targeted toward performance optimization. Several novel issues are addressed including partial matching and automatic clock selection.
Search for gluinos in events with an isolated lepton, jets and missing transverse momentum at $$\sqrt{s}$$ s = 13 Te V with the ATLAS detector (2016)

The results of a search for gluinos in final states with an isolated electron or muon, multiple jets and large missing transverse momentum using proton-proton collision data at a centre-of-mass energy of [Formula: see text] are presented. The dataset used was recorded in 2015 by the ATLAS experiment at the Large Hadron Collider and corresponds to an integrated luminosity of 3.2 fb[Formula: see text]. Six signal selections are defined that best exploit the signal characteristics. The data agree with the Standard Model background expectation in all six signal selections, and the largest deviation is a 2.1 standard deviation excess. The results are interpreted in a simplified model where pair-produced gluinos decay via the lightest chargino to the lightest neutralino. In this model, gluinos are excluded up to masses of approximately 1.6 Te V depending on the mass spectrum of the simplified model, thus surpassing the limits of previous searches.
CCDC 1485786: Experimental Crystal Structure Determination (2017)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Feature combination with Multi-Kernel Learning for fine-grained visual classification (2014)

This paper addresses the problem of fine-grained recognition in which local, mid-level features are used for classification. We propose to use the Multi-Kernel Learning framework to learn the relative importance of the features and to select optimal features with regards to the classification performance, in a principled way. Our results show improved classification results on common benchmarks for fine-grained classification, as compared to the best prior state-of-the-art methods. The proposed learning-based combination method also improves the concatenation combination approach which has been the standard practice in combining features so far.
Coupling Nanobuilding Block and Breath Figures Approaches for the Designed Construction of Hierarchically Templated Porous Materials and Membranes (2007)

The chemical strategies offered by the coupling of functional nanobuilding blocks (NBBs, made of surface hybrided nanoparticles of SiO2, TiO2, Co, and CdS) and breath figures processing allows for the development of new porous materials with hierarchical porosity. Honeycomb-like macroporous membranes or films made of metallic oxides, metals, or chalcogenides having mesoporous walls can be easily obtained. The presented strategy is general, simple, and versatile and allows for the assembling of a large variety of structurally well-defined nanoparticles with very different chemical compositions into complex porous architectures. Moreover, the adjustable size of the nanobuilding block unit permits an easy tuning of the average size of the mesoporosity between 2 and 50 nm.