gebhart/patrepeval huggingface dataset:
Dynamic Security Optimization for N-1 Secure Operation of Hawai‘i Island System With 100% Inverter-Based Resources (2021)

Reliable power system operation with 100% inverter-based resources (IBRs) is an unsolved and challenging problem. One of the most challenging factors is ensuring power system stability after N-1 contingencies. This paper presents a promising solution using an operator support system (OSS) to enable stable operation of power system with up to 100% IBR generation. The OSS consists of two components. First is dynamic security assessment to evaluate the system resiliency, and identify critical N-1 contingencies that could endanger the system. The second component, as the key technology behind the OSS, is dynamic security optimization (DSO). The DSO optimizes the control parameters of generators and inverters to improve the stability of the system towards the identified N-1 contingencies. The key to system with 100% IBRs, as emphasized in many recent studies, is to establish the grid frequency reference using grid-forming (GFM) inverters. We show through high-fidelity Electro-Magnetic-Transient (EMT) simulations of the future generation models of Hawai‘i Island system with 100% IBR capacity that a system with 100% IBRs can be operated stably with the help of GFM inverters, and appropriate controller parameters can be found by DSO for the inverters. The DSO is verified via 28 critical N-1 contingencies of Hawai‘i Island system identified by Hawaiian Electric. The simulation results verify the effectiveness of DSO, and show significant stability improvement from DSO.
Millstone: software for multiplex microbial genome analysis and engineering (2017)

Inexpensive DNA sequencing and advances in genome editing have made computational analysis a major rate-limiting step in adaptive laboratory evolution and microbial genome engineering. We describe Millstone, a web-based platform that automates genotype comparison and visualization for projects with up to hundreds of genomic samples. To enable iterative genome engineering, Millstone allows users to design oligonucleotide libraries and create successive versions of reference genomes. Millstone is open source and easily deployable to a cloud platform, local cluster, or desktop, making it a scalable solution for any lab.
Respiratory Syncytial Virus Neutralizing Activity in Nasal Secretions Following Natural Infection (1969)

SummaryThe development of RS virus neutralizing activity in nasal secretions was documented in 7 of 17 infants and children who were hospitalized for RS virus lower respiratory tract disease. Most of the patients in whom a rise in secretory neutralizing activity did not occur possessed moderately high levels of such activity in secretions collected at the time of admission to the hospital. At present we favor the view that this acute phase neutralizing activity represents antibody which developed early in the course of infection (possibly earlier than serum antibody) rather than the alternate possibility of nonspecific inhibitors in secretions.
In Situ Characterization of Pharmaceutical Formulations by Dynamic Nuclear Polarization Enhanced MAS NMR (2017)

A principal advantage of magic angle spinning (MAS) NMR spectroscopy lies in its ability to determine molecular structure in a noninvasive and quantitative manner. Accordingly, MAS should be widely applicable to studies of the structure of active pharmaceutical ingredients (API) and formulations. However, the low sensitivity encountered in spectroscopy of natural abundance APIs present at low concentration has limited the success of MAS experiments. Dynamic nuclear polarization (DNP) enhances NMR sensitivity and can be used to circumvent this problem provided that suitable paramagnetic polarizing agent can be incorporated into the system without altering the integrity of solid dosages. Here, we demonstrate that DNP polarizing agents can be added in situ during the preparation of amorphous solid dispersions (ASDs) via spray drying and hot-melt extrusion so that ASDs can be examined during drug development. Specifically, the dependence of DNP enhancement on sample composition, radical concentration, relaxation properties of the API and excipients, types of polarizing agents and proton density, has been thoroughly investigated. Optimal enhancement values are obtained from ASDs containing 1% w/w radical concentration. Both polarizing agents TOTAPOL and AMUPol provided reasonable enhancements. Partial deuteration of the excipient produced 3× higher enhancement values. With these parameters, an ASD containing posaconazole and vinyl acetate yields a 32-fold enhancement which presumably results in a reduction of NMR measurement time by ∼1000. This boost in signal intensity enables the full assignment of the natural abundance pharmaceutical formulation through multidimensional correlation experiments.
Robustness Analysis of Face Obscuration (2019)

Face obscuration is needed by law enforcement and mass media outlets to guarantee privacy. Sharing sensitive content where obscuration or redaction techniques have failed to completely remove all identifiable traces can lead to many legal and social issues. Hence, we need to be able to systematically measure the face obscuration performance of a given technique. In this paper we propose to measure the effectiveness of eight obscuration techniques. We do so by attacking the redacted faces in three scenarios: obscured face identification, verification, and reconstruction. Threat modeling is also considered to provide a vulnerability analysis for each studied obscuration technique. Based on our evaluation, we show that the k-same based methods are the most effective.
Total synthesis from L-quebrachitol of the D-myo-inositol 1,4,5-trisphosphate analogue, L-chiro-inositol 2,3,5-trisphosphate, a potent inositol 1,4,5-trisphosphate 5-phosphatase and 3-kinase inhibitor (1991)

A concise synthesis of L-chiro-inositol 2,3,5-trisphosphate, a novel receptor agonist and a potent inhibitor of the metabolic enzymes which act upon D-myo-Inositol 1,4,5-trisphosphate, is reported using methodology which accomplishes the required regio-protection of L-chiro-inositol for phosphorylation in one step.
Effect of Silica Nanoparticles on the Local Segmental Dynamics in Polyvinylacetate (2008)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation R. B. Bogoslovov, C. M. Roland, A. R. Ellis, A. M. Randall, C. G. Robertson; Effect of Silica Nanoparticles on the Local Segmental Dynamics in Polyvinylacetate. AIP Conf. Proc. 7 July 2008; 1027 (1): 1315–1317. https://doi.org/10.1063/1.2964557 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Studies on infiltrating host cells harvested from acutely rejecting rat cardiac allografts. (1976)

Although the cellular events of rejection of organ allografts have been fully described histologically, little information exists regarding actual mechanisms of graft destruction. Available concepts are based primarily upon assays performed in vitro. This study describes a model designed to correlate such in vitro information with events occurring in vivo within acutely rejecting organ allografts. Infiltrating host cells had been harvested by two techniques from heterotopic cardiac allografts in rats. The various cell classes have been noted and their differential rates of accumulation compared to serial histological observations. Subpopulations of cells have been identified by surface markers, and specific cytotoxicity against donor alloantigen has been determined as a T lymphocyte function. These techniques may be of aid in unraveling the complexities of graft rejection.
Organic light-emitting diode with ITO/organic photonic crystal (2003)

An organic light-emitting diode with a photonic crystal formed between indium–tin–oxide (ITO) and organic layers is demonstrated. Improvements of 50 and 140% in luminance efficiency and peak intensity, respectively, are successfully achieved compared with samples without photonic crystals, due to the enhancement of light extraction efficiency for confined modes in ITO/organic layers by photonic crystal effect.
Tailored side‐chain architecture of benzil voltage stabilizers for enhanced dielectric strength of cross‐linked polyethylene (2014)

ABSTRACT The synthesis and physico‐chemical properties of seven benzil‐type voltage stabilizers are reported. The benzil core is substituted with alkyl chains of different length that are linked to the benzil core via an ester, ether, or tertiary amine group. All additives can be melt‐processed with low‐density polyethylene (LDPE). Fourier‐transform infrared spectroscopy confirms that benzil compounds are not affected by the LDPE cross‐linking reaction induced by dicumyl peroxide. Moreover, a combination of gel content measurements, thermal analysis, and small‐angle X‐ray scattering indicates that the presence of benzil voltage stabilizers does not significantly alter the microstructure of cross‐linked polyethylene (XLPE). Electrical tree inhibition experiments under high‐voltage alternating current conditions show that all investigated additives substantially enhance the dielectric strength of the insulating material at a concentration of only 10 mmol kg −1 . The highest improvement in dielectric strength, of more than 70% with respect to reference XLPE, is obtained with voltage stabilizers, which carry short (methyl) side chains that are linked to the benzil core via an ester or tertiary amine group. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2014 , 52 , 1047–1054
The Development of a Dry Low NOx Combustion System for the EGT Typhoon (1997)

This paper describes the development of an ultra low NOx (i.e. sub 10 ppmvd) combustion system from the successful completion of a high pressure rig programme, to the installation of the system on a gas turbine in commercial operation. It includes a detailed description of early screening tests for DLN concepts and an explanation of how these were developed on both rig and engine test bed. Specific discussions include the concepts and technology for: 1) NOx reduction 2) Optimisation of premix turndown for carbon monoxide control at part load conditions 3) Control of combustion driven pressure oscillation (combustor dynamics) and the failures resulting from the lack of control. In addition to the DLN aerothermal development, an outline description of the combustor mechanical design and the control and systems modification from the conventional combustion system is given.
Ultrathin-film hydrogen gas sensor with nanostructurally modified surface (2014)

The change in electrical resistance of Pt thin films on glass substrates upon exposure to hydrogen gas at room temperature was studied. The effect was detectible only for film thicknesses of less than 40 nm, and increased with decreasing thickness. Samples were also produced with a Ti film inserted between the Pt film and the glass substrate as an adhesive layer. Although the Ti film did not react with the hydrogen gas, its presence reduced the resistance change effect because it acted as a parallel resistance. To overcome this problem, the surface of the glass substrate was nanostructurally modified using porous SiO2, which led to a larger resistance change ratio. To improve the recovery time, heating by pulsed current injection was carried out. A structure consisting of Pt (5 nm)/Ti (3 nm)/porous SiO2/glass was found to show a clear response to hydrogen concentrations down to about 100 ppm at room temperature.
Gas-liquid Taylor flow in microchannels (2012)

Cette étude, comportant un volet expérimental et un volet numérique, vise à mieux comprendre l'hydrodynamique des écoulements de Taylor gaz-liquide en microcanaux rectangulaires (dh ~ 500 µm). L'étape de génération des bulles lors de la mise en contact des fluides est étudiée à travers la taille des poches de gaz et bouchons liquides ainsi que la fréquence de formation. La dynamique de l'écoulement établi est également analysée (forme des bulles, épaisseur de film, vitesse).
Adsorption Study of Carbon Dioxide in 'L' Shaped Slit Pores at High Temperatures and Pressuers Using Monte Carlo Simulations (2020)

CO2 capture from high operating temperatures are of special interest as it is economically appealing over low temperature CO2 capture process in Postcombustion capture. This work contributes to the estimation of new and complementary density data for CO2 confined in 'L' shaped carbon slit pores at high temperatures and pressures. CO2 adsorption capacities in 'L' shaped carbon slit pores of heights 20, 31.6, 63.2, 94.85 and 126.5 at 673.15 K and 873.15 K over a pressure range of 500 kPa to 4000 kPa are predicted by Grand Canonical Monte Carlo simulations. Elementary Physical Model is employed to model CO2 at these temperatures and pressures both in bulk and confined phase. CO2 adsorption capacities and the unique structural properties of the confined CO2 at all the condition mentioned above has been estimated in presence of the wall-fluid interactions and the fluidfluid interactions. The Steele wall potential is used to model the wall-fluid interactions inside carbon-based adsorbents that have a slit shaped geometry.
Fundamental Considerations for Genetically-Guided Pain Management with Opioids Based on CYP2D6 and OPRM1 Polymorphisms. (2018)

Pain management, opioids, CYP2D6, OPRM1, clinical decision support, pharmacokinetics, pharmacodynamics, pharmacogenetics, combinatorial genotypes.
Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment (2020)

Androgen receptor (AR) antagonists, such as enzalutamide, have had a major impact on the treatment of metastatic castration-resistant prostate cancer (CRPC). However, even with the advent of AR antagonist therapies, patients continue to develop resistance, and new strategies to combat continued AR signalling are needed. Here, we develop AR degraders using PROteolysis TArgeting Chimeric (PROTAC) technology in order to determine whether depletion of AR protein can overcome mechanisms of resistance commonly associated with current AR-targeting therapies. ARD-61 is the most potent of the AR degraders and effectively induces on-target AR degradation with a mechanism consistent with the PROTAC design. Compared to clinically-approved AR antagonists, administration of ARD-61 in vitro and in vivo results in more potent anti-proliferative, pro-apoptotic effects and attenuation of downstream AR target gene expression in prostate cancer cells. Importantly, we demonstrate that ARD-61 functions in enzalutamide-resistant model systems, characterized by diverse proposed mechanisms of resistance that include AR amplification/overexpression, AR mutation, and expression of AR splice variants, such as AR-V7. While AR degraders are unable to bind and degrade AR-V7, they continue to inhibit tumor cell growth in models overexpressing AR-V7. To further explore this, we developed several isogenic prostate cell line models in which AR-V7 is highly expressed, which also failed to influence the cell inhibitory effects of AR degraders, suggesting that AR-V7 is not a functional resistance mechanism for AR antagonism. These data provide compelling evidence that full-length AR remains a prominent oncogenic driver of prostate cancers which have developed resistance to AR antagonists and highlight the clinical potential of AR degraders for treatment of CRPC.
Stress Distribution in Teeth Due to Dimensional Changes of the Restorative Material (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Synthesis and Structure of a 22 × 12 × 12 Extra-Large Pore Zeolite ITQ-56 Determined by 3D Electron Diffraction (2021)

A multidimensional extra-large pore germanosilicate, denoted ITQ-56, has been synthesized by using modified memantine as an organic structure-directing agent. ITQ-56 crystallizes as plate-like nanocrystals. Its structure was determined by 3D electron diffraction/MicroED. The structure of ITQ-56 contains extra-large 22-ring channels intersecting with straight 12-ring channels. ITQ-56 is the first zeolite with 22-ring pores, which is a result of ordered vacancies of double 4-ring (<i>d</i>4<i>r</i>) units in a fully connected zeolite framework. The framework density is as low as 12.4 T atoms/1000 Å<sup>3</sup>. The discovery of the ITQ-56 structure not only fills the missing member of extra-large pore zeolite with 22-ring channels but also creates a new approach of making extra-large pore zeolites by introducing ordered vacancies in zeolite frameworks.
Neural systems of second language reading are shaped by native language (2003)

Reading in a second language (L2) is a complex task that entails an interaction between L2 and the native language (L1). To study the underlying mechanisms, we used functional magnetic resonance imaging (fMRI) to visualize Chinese-English bilinguals' brain activity in phonological processing of logographic Chinese and alphabetic English, two written languages with a sharp contrast in phonology and orthography. In Experiment 1, we found that phonological processing of Chinese characters recruits a neural system involving left middle frontal and posterior parietal gyri, cortical regions that are known to contribute to spatial information representation, spatial working memory, and coordination of cognitive resources as a central executive system. We assume that the peak activation of this system is relevant to the unique feature of Chinese that a logographic character has a square configuration that maps onto a monosyllabic unit of speech. Equally important, when our bilingual subjects performed a phonological task on English words, this neural system was most active, whereas brain areas mediating English monolinguals' fine-grained phonemic analysis, as demonstrated by Experiment 2, were only weakly activated. This suggests that our bilingual subjects were applying their L1 system to L2 reading and that the lack of letter-to-sound conversion rules in Chinese led Chinese readers to being less capable of processing English by recourse to an analytic reading system on which English monolinguals rely. Our brain imaging findings lend strongest support to the idea that language experience tunes the cortex.
ChemInform Abstract: Unusual Ring Contraction by Substitution of 4‐O‐Activated‐pentono‐1,5‐lactams with Cyanide. Stereospecific Synthesis of 6‐Amino‐1,4,5,6‐ tetradeoxy‐1,4‐imino‐hexitols. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Politique culturelle et gouvernance urbaine : l'exemple de Rennes (1998)

Le cadre d'analyse de la gouvernance aide à comprendre les évolutions des politiques culturelles des villes en élargissant le regard vers des variables externes à l'organisation du secteur d'action publique qu'elles constituent. Le développement des politiques culturelles dans les grandes villes s'explique par le fait qu'elles sont centrales pour les élites urbaines qui tentent de constituer et/ou de faire apparaître les villes comme des acteurs politiques et sociaux et comme des sociétés locales. L'analyse du cas rennais, qui a longtemps été à l'avant-garde des transformations de l'action culturelle, fait apparaître deux périodes successives : celle du développement de la culture dans une gouvernance fortement intégrée (1977-1990) et celle d'une autonomisation relative du secteur liée à l'affaiblissement de la gouvernance rennaise (1990-1995).
Passive abatement of acid rock drainage by sulfate reducing bacteria (1996)

Passive treatment systems for Acid Rock Drainage (ARD) using wetland technology have been in development at eastern coal mines since the mid 1980s. Due to the high altitudes, remoteness, lack of large flat areas, and/or heavy metal levels at western mine sites, application of this technology has been lacking. This research explored whether pine sawdust can be used as sole carbon source in a smaller volume system for ARD remediation which can handle high throughputs. The technology utilizes sulfate reducing bacteria (SRB) to precipitate metal sulfides from their sulfates, while raising pH due to net consumption of H{sup +}. Laboratory results indicate that indigenous SRB are present in mud obtained from a northern Idaho mine site. With partially degraded lodgepole pine sawdust as carbon source, 50-99% reduction of various metals, and pH increases from 3 to about 7 were attained in ARD collected from mine seeps. Thus, this system appears promising as a long term, low cost/maintenance technology for ARD remediation at remote western mines.
A packaging robot for complex cartons (2006)

Purpose To demonstrate the feasibility of designing a versatile packaging machine for folding cartons of complex geometry and shapes. Design/methodology/approach The research conducts study of cartons of different geometry and shapes classifying them in suitable types and operations that a machine can understand, conceptualizing a machine that can handle such cartons, modeling and simulation of the machine, and finally design and development of the packaging machine. Findings It has been shown that such a versatile machine is a possibility; it just needs miniaturization and investment on its development when such machines could be a reality. Research limitations/implications This research was aimed at proving the principle, but for practical implementation considerations need to be given for a compact, portable system incorporating sensors. Originality/value The design is unique in existence and has been shown to fold cartons of different complexity.
Wavelength-division-multiplexing-based electronic-photonic integrated circuits for high-performance data processing and transportation (2021)

This Conference Presentation, “Wavelength-division-multiplexing-based electronic-photonic integrated circuits for high-performance data processing and transportation,” was recorded for the Photonics West 2021 Digital Forum.
Variable angle of incidence spectroscopic ellipsometry: Application to GaAs-AlxGa1−xAs multiple heterostructures (1986)

The sensitivity of spectroscopic ellipsometry data to multilayer model parameters is shown to be a strong function of the angle of incidence. A quantitative study of sensitivity versus angle of incidence is performed for a GaAs-AlxGa1−xAs-GaAs substrate structure, showing that maximum sensitivity to layer thicknesses and AlGaAs composition occurs near the wavelength-dependent principal angle. These results are verified by experimental measurements on two molecular-beam epitaxy grown samples. New spectral features, not found in previous ellipsometry studies of similar structures, are also reported.
Primary prevention for skin photoaging (2015)

Mathjax On | Off Abstract Rejuvenation and slowing of the aging process have always been major goals in dermatology. Strategies for medical treatment of and intervention in cutaneous aging and/or photoaging have included (a) measures for prevention against UV damage and (b) medications and procedures to reverse existing aging.