gebhart/patrepeval huggingface dataset:
A Novel Endovascular Device for Emboli Rerouting (2008)

It is proposed that this device could be used to reroute emboli away from important intracranial vessels as a means of stroke prevention.
Modeling Functional Specifications of Ground Systems in the NAS (2016)

The goal of the Airspace operations and Safety Program (AOSP) at NASA is to develop new concepts and technologies for air traffic management that can be integrated within the National Airspace (NAS ...
Acromioclavicular Joint Injuries: Effective Rehabilitation (2021)

Rehabilitation protocols for AC joint injuries should be less formulaic and instead allow for critical thinking and effective communication among clinicians and therapists to address individual patient needs.
Probing the spinor nature of electronic states in nanosize non-collinear magnets (2016)

Non-collinear magnetization textures provide a route to novel device concepts in spintronics. These applications require laterally confined non-collinear magnets (NCM). A crucial aspect for potential applications is how the spatial proximity between the NCM and vacuum or another material impacts the magnetization texture on the nanoscale. We focus on a prototypical exchange-driven NCM given by the helical spin order of bilayer Fe on Cu(111). Spin-polarized scanning tunnelling spectroscopy and density functional theory reveal a nanosize- and proximity-driven modification of the electronic and magnetic structure of the NCM in interfacial contact with a ferromagnet or with vacuum. An intriguing non-collinearity between the local magnetization in the sample and the electronic magnetization probed above its surface results. It is a direct consequence of the spinor nature of electronic states in NCM. Our findings provide a possible route for advanced control of nanoscale spin textures by confinement.
Optoelectronic switches based on diffusive conduction (2006)

We study the process of diffusive conduction that we use in our optoelectronic switches to achieve rapid optical switching (on a picosecond time scale). We present the characteristic Green’s function of the diffusive conduction derived for arbitrary initial conditions. We also report the series solutions of the diffusive conduction obtained for different boundary conditions (V=0 and ∇V=0 along the device contact lines) in different device geometries (rectangular and circular mesas). Using these analytical results, we investigate the effect of boundary conditions on the switching operation and the steady state behavior in optical links. We demonstrate the feasibility of using such diffusive conductive optoelectronic switches to establish optical links in return-to-zero and non-return-to-zero coding schemes. For multichannel optical switching, we discuss possible use of a single optoelectronic switch to accommodate multiple channels at once, with &amp;gt;100 optical channels (with a 2000mm−2 channel density and &amp;lt;10% cross-talk), predicted on a 300×300μm2 mesa with a device switching bandwidth of &amp;gt;50GHz, leading to a 5Tb∕s aggregate transmission in principle. This approach of using multiple parallel channels on a single switch is completely opposite to the traditional idea of arraying many switches. This proposed scheme eliminates the need for on-chip switch integration and the need for the alignment of the optical channels to the integrated individual switches.
The reduction of C* bonds proceeds with retention of configuration: stereochemical investigation of the heterogeneous reduction by dideuterium of (homohypostrophene)neopentyl(2-norbornyl)platinum(II) complexes on platinum black (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe reduction of C* bonds proceeds with retention of configuration: stereochemical investigation of the heterogeneous reduction by dideuterium of (homohypostrophene)neopentyl(2-norbornyl)platinum(II) complexes on platinum blackT. Randall Lee, Derk A. Wierda, and George M. WhitesidesCite this: J. Am. Chem. Soc. 1991, 113, 23, 8745–8753Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://pubs.acs.org/doi/10.1021/ja00023a022https://doi.org/10.1021/ja00023a022research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Chain and Ion Dynamics in Precise Polyethylene Ionomers (2019)

We analyze the dynamics from microsecond-long, atomistic molecular dynamics (MD) simulations of a series of precise poly(ethylene-co-acrylic acid) ionomers neutralized with lithium, with three different spacer lengths between acid groups on the ionomers and at two temperatures. At short times, the intermediate structure factor calculated from the MD simulations is in reasonable agreement with quasi-elastic neutron scattering data for partially neutralized ionomers. For ionomers that are 100% neutralized with lithium, the simulations reveal three dynamic processes in the chain dynamics. The fast process corresponds to hydration librations, the medium-time process corresponds to local conformational motions of the portions of the chains between ionic aggregates, and the long-time process corresponds to relaxation of the ionic aggregates. At 600 K, the dynamics are sufficiently fast to observe the early stages of lithium-ion motion and ionic aggregate rearrangements. In the partially neutralized ionomers with isolated ionic aggregates, the Li-ion-containing aggregates rearrange by a process of merging and breaking up, similar to what has been observed in coarse-grained (CG) simulations. In the 100% neutralized ionomers that contain percolated ionic aggregates, the chains remain pinned by the percolated aggregate at long times, but the lithium ions are able to move along the percolated aggregate. Here, the ion dynamics are also qualitatively similar to those seen in previous CG simulations.
Aortic Valve Replacement With the Freestyle Stentless Bioprosthesis : Five-Year Experience (1999)

The Freestyle stentless valve can be implanted safely in the elderly with excellent midterm clinical results. It has superb hemodynamics in terms of residual transvalvular gradient, effective orifice area, and regression of left ventricular hypertrophy.
Photonic Crystals and Quantum Dots: Towards Integrated Optics for Advanced Ultra-Fast All-Optical Signal Processing (2006)

Nano-photonic technologies of GaAs-based two-dimensional photonic crystal (2DPC) slab waveguides and InAs-based quantum dots (QDs) are reviewed for a symmetric Mach-Zehnder type, ultra-small and ultra-fast all-optical switch (PC-SMZ) and new logic (PC-FF) device.
Building Blocks for Intrachip Optical Network (2008)

CMOS compatible photonic devices are at the point where integration with electronics is feasible. We will show how our ultra low power photonic devices can be utilized in an intrachip optical network, supporting multicore processing.
Cushing's Syndrome Found During Long-Term Glucocorticoid Treatment for Rheumatoid Arthritis in an Elderly Woman. (1992)

A 69-year-old female patient had been treated with glucocorticoid for eight years because of rheumatoid arthritis. She showed characteristic Cushingoid features such as central obesity, moon face, and fragility of skin and vessels. She was disabled because of spinal compression fracture and muscle weakness. The blood pressure was 186/100 mmHg and the laboratory tests revealed serum K: 2.8 mEq/l, WBC: 15, 510/mm3, total cholesterol: 310 mg/dl. These suggested that she had iatrogenic Cushing's syndrome. After discontinuation of glucocorticoid, however, the serum cortisol level remained high. This fact prompted us to conduct further examinations for Cushing's syndrome. Oral dexamethasone administration did not suppress the plasma cortisol level and a left adrenal adenoma was found on abdominal CT scan. Because of the presence of bleeding diathesis, operation for adenoma was contraindicated. Though we tried to treat her with metyrapone, trilostane or opeprim (OP'-DDD), we had to abandon specific treatment because of severe side effects such as acute adrenal dysfunction and gastrointestinal problems. Decrease in the endogenous cortisol level after metyrapone treatment caused exacerbation of symptoms of rheumatoid arthritis. This is a peculiar case in which the long-term administration of glucocorticoid for rheumatoid arthritis might have concealed Cushing's syndrome, and conversely the increased intrinsic adrenal steroid hormone might have suppressed the activity of the rheumatoid arthritis.
SRLB: The Power of Choices in Load Balancing with Segment Routing (2017)

Network load-balancers generally either do not take application state into account, or do so at the cost of a centralized monitoring system. This paper introduces a load-balancer running exclusively within the IP forwarding plane, i.e. in an application protocol agnostic fashion - yet which still provides application-awareness and makes real-time, decentralized decisions. To that end, IPv6 Segment Routing is used to direct data packets from a new flow through a chain of candidate servers, until one decides to accept the connection, based on its local state. This way, applications themselves naturally decide on how to share incoming connections, while incurring minimal network overhead, and no out-of-band signaling. Tests on different workloads - including realistic workloads such as replaying actual Wikipedia access traffic towards a set of replica Wikipedia instances - show significant performance benefits, in terms of shorter response times, when compared to a traditional random load-balancer.
Cyclopropanation Mediated by Zinc Organometallics (2009)

Abstract Introduction Preparation and Structure of Zinc Carbenoids Mechanism of the Cyclopropanation of Alkenes using Zinc Carbenoids Synthetic Scope of the Cyclopropanation using Zinc Carbenoids Conclusion
Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors (2007)

A novel series of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones have been synthesized as potent and selective checkpoint kinase 1 (Chk1) inhibitors via structure-based design. Aided by protein X-ray crystallography, medicinal chemistry efforts led to the identification of compound 46d, with potent enzymatic activity against Chk1 kinase. While maintaining a low cytotoxicity of its own, compound 46d exhibited a strong ability to abrogate G2 arrest and increased the cytotoxicity of camptothecin by 19-fold against SW620 cells. Pharmacokinetic studies revealed that it had a moderate bioavailabilty of 20% in mice. Two important binding interactions between compound 46b and Chk1 kinase, revealed by X-ray cocrystal structure, were hydrogen bonds between the hinge region and the amide bond of the core structure and a hydrogen bond between the methoxy group and Lys38 of the protein.
Redacting sensitive information in software artifacts (2014)

In the past decade, there have been many well-publicized cases of source code leaking from different well-known companies. These leaks pose a serious problem when the source code contains sensitive information encoded in its identifier names and comments. Unfortunately, redacting the sensitive information requires obfuscating the identifiers, which will quickly interfere with program comprehension. Program comprehension is key for programmers in understanding the source code, so sensitive information is often left unredacted.
Discovery of Novel Small-Molecule Inhibitors of SARS-CoV-2 Main Protease as Potential Leads for COVID-19 Treatment (2021)

The main protease of SARS-CoV-2 virus, M<sup>pro</sup>, is an essential element for viral replication, and inhibitors targeting M<sup>pro</sup> are currently being investigated in many drug development programs as a possible treatment for COVID-19. An <i>in vitro</i> pilot screen of a highly focused collection of compounds was initiated to identify new lead scaffolds for M<sup>pro</sup>. These efforts identified a number of hits. The most effective of these was compound SIMR-2418 having an inhibitory IC<sub>50</sub> value of 20.7 μM. Molecular modeling studies were performed to understand the binding characteristics of the identified compounds. The presence of a cyclohexenone warhead group facilitated covalent binding with the Cys<sup>145</sup> residue of M<sup>pro</sup>. Our results highlight the challenges of targeting M<sup>pro</sup> protease and pave the way toward the discovery of potent lead molecules.
Supersingular isogeny graphs in cryptography (2019)

We describe recent applications of expander graphs in cryptography, particularly supersingular isogeny graphs. The security of these cryptographic constructions relies on the assumption that computing paths in these graphs is practically infeasible, even with a quantum computer. One of these cryptographic constructions is currently considered for standardization by NIST. We also recall a related construction based on Lubotzky- Philips-Sarnak’s celebrated Ramanujan graphs. We describe an efficient path-finding algorithm for these graphs which was motivated by the cryptographic application, and we mention connections to the problem of optimal quantum circuit synthesis.
Non-Monte-Carlo methodology for high-sigma simulations of circuits under workload-dependent BTI degradation&#x2014;Application to 6T SRAM (2014)

Recent advances in understanding Bias Temperature Instability (BTI) in terms of individual gate oxide defects has created a paradigm shift towards describing degradation in terms of time-dependent variability. This added time dimension to the variability analysis has proven to be a considerable design challenge. Moreover, the non-normally distributed ΔV <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</inf> shifts create compatibility issues with the current SotA statistical assessments techniques for evaluating high sigma yield of SRAM cells. Here we present a novel Non-Monte-Carlo numerical simulation methodology capable of evaluating circuit performance under workload-dependent BTI degradation.
High-Resolution Fluorescent In Situ Hybridization of Drosophila Embryos and Tissues: Figure 1. (2008)

INTRODUCTIONFluorescent in situ hybridization (FISH) is commonly used to analyze the three-dimensional distribution of RNAs in intact embryos and tissues. Tyramide signal amplification (TSA) significantly increases the sensitivity and resolution of FISH probe signals. This protocol includes optimized TSA-FISH procedures for Drosophila embryos, ovaries, and larval tissues. Instructions are given for the preparation of RNA probes, the collection and fixation of tissues, and the hybridization and TSA-mediated detection of probes, including options for high-throughput processing in 96-well plates. Variations of the procedure for RNA-RNA and RNA-protein costaining are also described.
Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro (1995)

Primary lung fibroblasts were isolated from patients with idiopathic pulmonary fibrosis (HIPF), from normal human lung tissue (NH), from rats treated with 75% oxygen and paraquat (PA), and from normal adult rats (NR). Serum-free media conditioned by each fibroblast strain were tested on the human A549 cell line (HIPF and NH media) or on primary alveolar epithelial cells (AEC) isolated from normal adult rats (PA or NR media). Over 20-h incubation, HIPF- or PA-conditioned media induced DNA fragmentation and significant decreases in total recoverable DNA and cell number of A549 or AEC, respectively; NH or NR media had no significant effect relative to serum-free unconditioned media. Apoptosis of A549 and AEC was detected by altered nuclear morphology and was confirmed by terminal deoxynucleotidyl transferase-mediated bio-dUTP nick end labeling. The endonuclease inhibitors 10 microM aurintricarboxylic acid and 50 microM zinc inhibited HIPF-induced apoptosis of A549 cells by 68 and 71%, respectively. Both apoptosis and necrosis were induced by HIPF and PA media in a concentration-dependent manner. These results suggest that altered fibroblasts emerging during fibrotic lung injury release a soluble factor(s) capable of inducing cell death and net loss of AEC.
Long-Term Follow-up in Peripartum Cardiomyopathy Patients with Contemporary Treatment: Low Mortality, High Cardiac Recovery, but Significant Cardiovascular Co-Morbidities (2019)

Our PPCM collective treated with standard therapy for heart failure, dopamine D2 receptor agonists, and anticoagulation displays a high and stable long-term recovery rate with low mortality at 5-year follow-up. However, long-term use of cardiovascular medication, persisting or de novo hypertension and arrhythmias were frequent.
Inhibitors of the Ras superfamily G-proteins (2013)

Discovery of Small-Molecule Ras Inhibitors that Display Anti-Tumor Activity by Interfering with Ras*GTP-Effector Interaction Fumi Shima, Yoko Yoshikawa, Shigeyuki Matsumoto and Tohru Kataoka An Orthosteric Inhibitor of the RAS-SOS Interaction Seth Nickerson, Stephen T. Joy, Paramjit S. Arora and Dafna Bar-Sagi Conformation-Specific Inhibitors of Raf kinases Xiaolun Wang and Kristin Schleicher Inhibitors of the ERK Mitogen-activated Protein Kinase Cascade for Targeting RAS Mutant Cancers Leanna Gentry, Ahmed A. Samatar and Channing J. Der Inhibiting the RAS - PI3K Pathway in Cancer Therapy Clare Sheridan and Julian Downward The RalGEF/Ral Pathway: Evaluating an Intervention Opportunity for Ras Cancers Jonathan M. Cooper, Brian O. Bodemann and Michael A. White p21-Activated Kinase Inhibitors Joachim Rudolph, James J. Crawford, Klaus P. Hoeflich, and Jonathan Chernoff Recent Progress in Developing Small Molecule Inhibitors Designed to Interfere with Ras Membrane Association: Towards Inhibiting K-Ras and N-Ras Functions Fuyuhiko Tamanoi and Jie Lu Synthetic Lethal Genetic Screens in Ras Mutant Cancers Bing Yu and Ji Luo
CMOS transceiver with baud rate clock recovery for optical interconnects (2004)

An efficient baud rate clock and data recovery architecture is applied to a double sampling/integrating front-end receiver for optical interconnects. Receiver performance is analyzed and projected for future technologies. This front-end allows use of a 1:5 demux architecture to achieve 5Gb/s in a 0.25 /spl mu/m CMOS process. A 5:1 multiplexing transmitter is used to drive VCSELs for optical transmission. The transceiver chip consumes 145mW per link at 5Gb/s with a 2.5V supply.
ChemInform Abstract: Cu‐Catalyzed Formation of Triazole‐Linked Glycoamino Acids and Application in Chemoenzymatic Peptide Synthesis. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Epipolar Consistency in Fluoroscopy for Image-Based Tracking (2015)

Geometry and physics of absorption imaging impose certain constraints on X-ray projections. Recently, the Epipolar Consistency Conditions (ECC) have been introduced and applied to motion correction in flat-detector computed tomography (CT). They are based on redundant information in transmission images along epipolar lines. Unlike other consistency conditions for CT scans, they act directly on an arbitrary pair of X-ray images. This paper proposes an application of ECC to 3D patient tracking in interventional radiology. We evaluate the proposed method against 2D-3D registration with a previously acquired CT. Our experiments on synthetic data based on a patient CT and phantom data from an interventional C-arm demonstrate that our method is able to compensate online for rotations of up to ±10° and translations of ±25 mm between consecutive frames. We successfully track rotations of as much as 45° over 45 images. The outstanding property of the approach is that no 3D scan is required for tracking a 3D object in space. We show, that small rotations of about 3° in space and translations of about 50 mm can be tracked based on just two reference X-ray images. Since the proposed approach works directly on X-ray images, it exceeds regular 2D-3D registration with a CT in an order of magnitude in computational speed. We conclude that ECC are a simple and effective new tool for pre-aligment and online patient tracking for fluoroscopic sequences.
Current status of cancer immunotherapy for gynecologic malignancies (2020)

Recent cancer immunotherapy development with immune checkpoint inhibitors has shown durable clinical responses in a wide variety of tumor types. These drugs targeting programmed cell death 1, its ligand programmed death ligand 1 and cytotoxic T cell lymphocyte-associated antigen 4 have revolutionized the field of cancer treatment. It is of significant interest in optimizing the immunotherapy for cancer patients beyond the conventional treatments such as surgery, chemotherapy and radiation. Many clinical trials evaluating the safety and efficacy of various combined regimens with immune checkpoint inhibitors have been reported and are in progress. Among gynecologic malignancy, endometrial cancers have distinct subtypes with microsatellite instability-high status and polymerase ɛ mutation. These types have been shown to immunogenic tumors and appropriated candidate for immune checkpoint inhibitors. Also, recurrent cervical cancer showed a promising objective response with single anti-PD1 Ab treatment. Despite their definite outcome and considerable potential of immunotherapy, not all patients received a survival benefit and further understanding of human tumor immunology is essential to improve this type of therapy. In this review, we have summarized the updated results of clinical trials of cancer immunotherapy for gynecologic malignancies and discussed the future perspectives.