gebhart/patrepeval huggingface dataset:
Strong stabilizability of systems with multiaffine uncertainties and numerator denominator coupling (1994)

This paper considers a set of proper transfer functions whose numerator and denominator polynomial coefficients display dependent multiaffine parametric uncertainties. It is shown that provided no member transfer function has positive real pole-zero cancellations, all members satisfy the parity interlacing property iff all corner members do the same. Notice that while this implies that each member is strongly stabilizable, it does not imply the existence of a single stable controller that stabilizes the whole set. The paper also shows that whenever the numerator and denominator polynomials lie in dependent polytopes, the task of verifying the absence of positive real pole-zero cancellations can be accomplished by checking the edges.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
[High quality colonoscopy must be secured]. (2017)

High quality colonoscopy must be secured Colonoscopy plays a key role in the work-up of digestive diseases and constitutes the cornerstone in colorectal cancer diagnosis and prevention. Data suggest that the quality of colonoscopy varies widely between different endoscopists. This article summarizes current evidence and expert consensus on quality indicators, along with the evidence supporting their use in benchmarking, quality reporting, and continuous quality improvement in order to secure high quality colonoscopy. In particular, four quality indicators, i.e. adenoma detection rate, compliance with guidelines on intervals for endoscopic surveillance, cecal intubation rate and complications, should be monitored in endoscopy units to ensure that colonoscopy practice is of high quality. Proper performance and documentation of high quality colonoscopy is critical for reducing colorectal cancer incidence and mortality.
Analytical and clinical performance characteristics of Tandem-MP Ostase, a new immunoassay for serum bone alkaline phosphatase (1998)

The performance characteristics of the Tandem-MP Ostase assay, a new microplate immunoassay for bone-specific alkaline phosphatase (bone ALP; EC 3.1.3.1) in human sera, are described. Bone ALP is bound to streptavidin-coated microwells by a single biotinylated anti-bone ALP monoclonal antibody. Antigen is detected by the addition of p-nitrophenyl phosphate. The assay is performed at room temperature in <90 min. Imprecision was 2.3-6.1% with a detection limit of 0.6 microg/L. Method comparison of bone ALP measurements with the Tandem-MP Ostase assay and the mass-based Tandem-R Ostase assay (n = 285) indicated regression statistics of Tandem-MP Ostase = 1.03 Tandem-R Ostase + 0.22 microg/L, S(y/x) = 4.0 microg/L, r = 0.97. Serum bone ALP values in apparently healthy men and in pre- and postmenopausal women were also similar between the two Ostase assay formats. Liver ALP reactivity determined using the slope and heat inactivation methods was similar in both Ostase assays. Liver ALP reactivity ranged from 3 microg/L (heat inactivation) to 6 microg/L (slope method) per 100 U/L of liver ALP activity, whereas bone ALP reactivity was 37 microg/L per 100 U/L of bone ALP activity, indicating a liver ALP relative reactivity of 8.1-16.2%. Similar results were obtained with the Alkphase-B bone ALP immunoassay. The Tandem-MP Ostase bone ALP assay demonstrated increased concentrations of serum bone ALP in conditions where bone metabolism is increased and showed a rapid, temporal decrease in serum bone ALP in Paget disease patients on bisphosphonate therapy. In conclusion, the Tandem-MP Ostase assay for serum bone ALP is a rapid, simple, robust nonisotopic alternative to the Tandem-R Ostase immunoradiometric assay that provides an accurate and sensitive assessment of bone turnover.
Future Prospects of Gene Therapy for Treating CNS Diseases (2000)

In the last several decades, enormous gains have been made in our understanding of the pathogenesis of various human diseases. By understanding the biochemical, molecular, and genetic mechanisms through which a disease state manifests itself, it becomes possible to develop rational strategies for therapeutic intervention. In addition to providing insight into disease mechanisms, studies using molecular biology have provided a tool, gene therapy, through which it is possible to induce a cell to make a specific protein that could interfere with the disease process. Gene therapy provides for a local, regulated delivery of the therapeutic gene product, thereby avoiding some of the systemic side effects of drug therapies. Gene therapy has been investigated with some success in several organ systems and this review discusses efforts to use gene therapy in central nervous system (CNS) diseases. Considerations for using gene therapy and the benefits of various delivery approaches are addressed. The potential efficacy and drawbacks of gene therapy for CNS disease are discussed in light of advances in preclinical research. Finally, the future prospects for the use of gene therapy in the clinic are discussed in terms of safety, ethical considerations, and public opinion.
Loop distribution with multiple exits (1992)

The authors present a loop distribution algorithm that accommodates loops with multiple exits. The algorithm utilizes and appropriately transforms abstract representations of the program, rendering these structures suitable for further program transformations. Results from implementing this algorithm in the PTRAN system at IBM Research are presented. >
Netrin-1 receptor DCC is required for the contralateral topography of lamina I anterolateral system neurons (2020)

Anterolateral system (AS) neurons relay nociceptive information from the spinal cord to the brain, protecting the body from harm by evoking a variety of behaviours and autonomic responses. The developmental programs that guide the connectivity of AS neurons remain poorly understood. Spinofugal axons cross the spinal midline in response to Netrin-1 signalling through its receptor deleted in colorectal carcinoma (DCC); however, the relevance of this canonical pathway to AS neuron development has only been demonstrated recently. Here, we disrupted Netrin-1:DCC signalling developmentally in AS neurons and assessed the consequences on the path finding of the different classes of spinofugal neurons. Many lamina I AS neurons normally innervate the lateral parabrachial nucleus and periaqueductal gray on the contralateral side. The loss of DCC in the developing spinal cord resulted in increased frequency of ipsilateral projection of spinoparabrachial and spinoperiaqueductal gray neurons. Given that contralateral spinofugal projections are largely associated with somatotopic representation of the body, changes in the laterality of AS spinofugal projections may contribute to reduced precision in pain localization observed in mice and humans carrying Dcc mutations.
MRI of Injury to the Lateral Collateral Ligamentous Complex of the Ankle (1993)

We retrospectively evaluated the lateral collateral ligamentous complex of 43 patients who had complained of ankle pain following ankle sprain. The MR signs of ligamentous abnormality included discontinuity or absence, increased signal within the ligament, and ligamentous irregularity or waviness with normal thickness and signal intensity. Using these criteria, 30 anterior talofibular, 20 calcaneofibular, and no posterior talofibular ligament injuries were diagnosed. Compared with surgery (nine patients), MRI demonstrated six of seven anterior talofibular ligament injuries and six of six calcaneofibular ligament injuries. Magnetic resonance showed ligamentous abnormalities in 12 of 23 cases with normal stress radiography. Magnetic resonance imaging provides useful information for the evaluation of patients presenting with chronic pain after ankle sprain.
Voltage tunable two-color infrared detection using semiconductor superlattices (2003)

We demonstrate a voltage tunable two-color quantum-well infrared photodetector (QWIP) that consists of multiple periods of two distinct AlGaAs/GaAs superlattices separated by AlGaAs blocking barriers on one side and heavily doped GaAs layers on the other side. The detection peak switches from 9.5 μm under large positive bias to 6 μm under negative bias. The background-limited temperature is 55 K for 9.5 μm detection and 80 K for 6 μm detection. We also demonstrate that the corrugated-QWIP geometry is suitable for coupling normally incident light into the detector.
Orientation Dependence of Nonlinearity and Hysteresis in PZN-4.5%PT Single Crystals I: Unipolar Response (2006)

Relaxor ferroelectric crystals exhibit excellent electromechanical properties as well as strong anisotropy. In this study, compressive stress and electric field are applied to relaxor single crystals [Pb(Zn 1/3 Nb 2/3 )O 3 ]0.955–[PbTiO 3 ]0.045 (PZN-4.5%PT) in a series of crystal orientations between h001i and h111i, and the corresponding strain and electric displacement are measured. It is found that as the angle of the orientation cut is rotated from h001i to h111i, the piezoelectric coefficient d 33 drops and hysteresis loss increases dramatically. The piezoelectric coefficients, remnant strain, and remnant electric displacement are modeled using a volume averaging of crystal variant volume fractions.
30-Gbit/s OFDM Intensity Modulation of 1550-nm VCSEL (2012)

We experimentally demonstrate 30-Gbit/s (24.7-Gbit/s net) OFDM intensity modulation of a low-cost 1550-nm VCSEL. The optical OFDM signals transmission over 7-km G.655 SMF is also realized successfully.
Synthesis and characterization of albumin binding surfaces for implantable surfaces. (2004)

Implanted medical devices are of increasing importance in the practice of medicine and it is estimated that more than 3-million people in the United States have long-term implants like vascular grafts, pacemakers, catheters and joint replacements. Even though most biomedical polymers employed are relatively inert, unreactive, and non-toxic, most implant materials when contacted with blood invoke the activation of blood cells as well as the plasma proteolytic enzyme systems. In order to overcome aforementioned problems, attempts have been made to modify the surface chemistry of the blood-contacting biomaterials so that they become thromboresistant. One potential strategy to address the problem of the chaotic adsorption of proteins to medical devices and surfaces is to create a layer of albumin as a "barrier protein cover", as a thin layer of albumin has been reported to minimize adhesion and aggregation of platelets. By grafting peptides and synthetic ligands, that specifically bind human serum albumin, on an epoxide functionalized surface, we have generated surfaces that exhibit enhanced albumin binding over other serum proteins. We have characterized the surface using infra-red ellipsiometry and quantified protein adsorption via specific ELISA assays and gel electrophoresis.
The miR‐1908/SRM regulatory axis contributes to extracellular vesicle secretion in prostate cancer (2020)

Targeting extracellular vesicle (EV) secretion can have potential clinical implications for cancer therapy, however the precise regulatory mechanisms of EV secretion are not fully understood. Recently, we have shown a novel pathway of EV biogenesis in PCa cell lines, PC3 and PC3M. However, as the characteristics of EVs are divergent even among PCa cell lines, we hypothesized that other pathways or common regulatory pathways of EV biogenesis still exist. Here, we performed quantitative high-throughput screening to determine the key regulatory genes involved in EV biogenesis in 22Rv1 cells, which secrete a different type of EVs. In total, 1728 miRNAs were screened and miR-1908 was selected as the potential miRNA regulating EV biogenesis in 22Rv1 cells. Subsequently, we investigated target genes of miR-1908 using siRNA screening and identified that spermidine synthase (SRM) was the key regulator of EV secretion in 22Rv1 cells. Attenuation of SRM expression significantly inhibited secretion of EVs in 22Rv1 cells, and overexpression of SRM was confirmed in PCa tissues. Furthermore, we found that the number of endosome compartments was increased in cellular cytoplasm after knockdown of the SRM gene. In conclusion, our results showed that miR-1908-mediated regulation of SRM can control secretion of EVs in PCa. In addition, these data suggested that the EV secretion pathway was dependent on cellular characteristics.
Development of laser straightening (LS) strategies to remove distortion in welded aeronautical structures (2019)

Manufacturing of stiffened aeronautical structures requires the joining of stringers to thin skin. Structures targeted in this work are composed by Ti-6Al-4V (Grade 5) stringers and commercially pure Ti (cp-Ti, Grade 2) skin. The stringers are laser beam welded (LBW) to the skin in T-joint configuration. Despite the highly concentrated and relatively low heat input of the laser source, the reduced thickness of the skin (0.8 mm) leads to significant angular distortion and so- called “Zeppelin effect”. Moreover, buckling distortion is observed in medium size panels (500 x 500 mm) including several stringers. Within this study, laser straightening (LS) process has been developed to mitigate as-welded distortion. The process is applied on the reverse of the skin and is based on the temperature gradient mechanism (TGM). The same welding source (disk laser) and optic head were employed for both LBW and LS. Consequently, the complete manufacturing of the structure can be done in just one working station. Different LS strategies were applied with the aim of removing welding induced distortion. They included both constant and variable laser power runs, single and multiple runs and different scanning sequences. After optimization of LS process, medium size panels with maximum distortion of less than 2.6 mm were obtained. Initial distortion was higher than 11 mm, meaning that approximately 80% of welding induced distortion was effectively removed.
Temperature dependence of stacking faults in catalyst-free GaAs nanopillars (2013)

Impressive opto-electronic devices and transistors have recently been fabricated from GaAs nanopillars grown by catalyst-free selective-area epitaxy, but this growth technique has always resulted in high densities of stacking faults. A stacking fault occurs when atoms on the growing (111) surface occupy the sites of a hexagonal-close-pack (hcp) lattice instead of the normal face-centered-cubic (fcc) lattice sites. When stacking faults occur consecutively, the crystal structure is locally wurtzite instead of zinc-blende, and the resulting band offsets are known to negatively impact device performance. Here we present experimental and theoretical evidence that indicate stacking fault formation is related to the size of the critical nucleus, which is temperature dependent. The difference in energy between the hcp and fcc orientation of small nuclei is computed using density-function theory. The minimum energy difference of 0.22 eV is calculated for a nucleus with 21 atoms, so the population of nuclei in the hcp orientation is expected to decrease as the nucleus grows larger. The experiment shows that stacking fault occurrence is dramatically reduced from 22% to 3% by raising the growth temperature from 730 to 790 ° C. These data are interpreted using classical nucleation theory which dictates a larger critical nucleus at higher growth temperature.
Identification of signaling pathways, matrix-digestion enzymes, and motility components controlling Vibrio cholerae biofilm dispersal (2020)

Bacteria alternate between being free-swimming and existing as members of sessile multicellular communities called biofilms. The biofilm lifecycle occurs in three stages: cell attachment, biofilm maturation, and biofilm dispersal. <i>Vibrio cholerae</i> biofilms are hyperinfectious, and biofilm formation and dispersal are considered central to disease transmission. While biofilm formation is well studied, almost nothing is known about biofilm dispersal. Here, we conducted an imaging screen for <i>V. cholerae</i> mutants that fail to disperse, revealing three classes of dispersal components: signal transduction proteins, matrix-degradation enzymes, and motility factors. Signaling proteins dominated the screen and among them, we focused on an uncharacterized two-component sensory system that we term DbfS/DbfR for dispersal of biofilm sensor/regulator. Phospho-DbfR represses biofilm dispersal. DbfS dephosphorylates and thereby inactivates DbfR, which permits dispersal. Matrix degradation requires two enzymes: LapG, which cleaves adhesins, and RbmB, which digests matrix polysaccharides. Reorientation in swimming direction, mediated by CheY3, is necessary for cells to escape from the porous biofilm matrix. We suggest that these components act sequentially: signaling launches dispersal by terminating matrix production and triggering matrix digestion, and subsequent cell motility permits escape from biofilms. This study lays the groundwork for interventions aimed at modulating <i>V. cholerae</i> biofilm dispersal to ameliorate disease.
Supplementary Video from A Novel Engineered Anti-CD20 Tracer Enables Early Time PET Imaging in a Humanized Transgenic Mouse Model of B-cell Non-Hodgkins Lymphoma (2023)

&lt;p&gt;MP4 file 847K, Movie of 64Cu-Do-FN3 PET tracer in a huCD20TM mouse. PET/CT images of two groups of huCD20TM 4 h post-injection of 64Cu-Do-FN3 tracer. (Left) Mouse received only tracer (non-blocked); (Right) Mouse (blocked) with pre-dose of cold FN3, 2 h prior to tracer. The 64Cu-Do-FN3 tracer uptake by spleen without block is very high compared to the blocked mouse&lt;/p&gt;
Durability of Structural Adhesive Bonds (2021)

No AccessAdhesion and Adhesives TechnologyMar 2021Durability of Structural Adhesive BondsAlphonsus V. PociusAlphonsus V. PociusSearch for more papers by this authorhttps://doi.org/10.3139/9781569908501.009SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2021Pages: 263-275Print ISBN: 978-1-56990-855-6eISBN: 978-1-56990-850-1 Copyright & Permissions© 2021 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
A new type of information display device: Switchable electrowetting retroreflectors (2008)

The University of Cincinnati presents a cost effective and highest optical performing switchable retroreflector. Retroreflection with contrast ratio >10X, wider field of view (+ 10deg), wide spectrum and low operational power has been demonstrated.
Overview of quantitative trait loci investigated in this study. (2015)

1&lt;p&gt;The loci are named according to the first gene in the region of interest, starting at the 5′ end of the region.&lt;/p&gt;2&lt;p&gt;ROI = region of interest. Number of kb sequenced for the locus.&lt;/p&gt;3&lt;p&gt;Total Genes is the number of genes in the locus; Targeted Genes is the number of genes investigated in this study.&lt;/p&gt;4&lt;p&gt;Please see &lt;a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004147#pgen.1004147.s009" target="_blank"&gt;Table S3&lt;/a&gt; for a complete listing of all variant sites, along with their MAF and annotation.&lt;/p&gt;5&lt;p&gt;Phenotype abbreviations: TC = total cholesterol, LDL-C = low density lipoprotein cholesterol, HDL-C = high density lipoprotein cholesterol, TG = triglycerides, FG = Fasting Glucose, FI = Fasting Insulin. Previous association evidence for lipid traits is from Kathiresan &lt;i&gt;et al.&lt;/i&gt; 2008, Willer &lt;i&gt;et al.&lt;/i&gt; 2008 and Teslovich &lt;i&gt;et al.&lt;/i&gt; 2010; for glucose Dupuis &lt;i&gt;et al.&lt;/i&gt; 2010, and for insulin Sabatti &lt;i&gt;et al.&lt;/i&gt; 2009. The “array SNP” is the GWAS array-genotyped SNP (not sequence variant) with the smallest p-value to indicated traits in this study and is not necessarily the same SNP highlighted in previous studies.&lt;/p&gt;6&lt;p&gt;Array SNP MAF and p-values are taken from the current study.&lt;/p&gt;
Sonothrombolysis with Phospholipid-Coated Perfluoropropane Microbubbles (2005)

Compared to other modalities that might be employed for molecular imaging, ultrasound has some unique features. It is portable; highly adapted to the surgical environment; can be used for cavitation, heating, and tissue ablation; and is exquisitely sensitive to microbubbles. Using microbubbles as a contrast agent, ultrasound imaging can detect a single microbubble. Ultrasound in concert with bubbles can be used in NanoInvasive™ therapy and drug delivery. An example of NanoInvasive therapy is sonothrombolysis with microbubbles, or SonoLysis™.
Wetting Behavior of Carbon in Molten Carbonate (2012)

This paper aims at quantifying the wettability of the solid carbon fuel by the molten carbonate in a Direct Carbon Fuel Cell (DCFC), to understand its effect on DCFC performance. The wetting behavior of carbon (graphite) under different conditions is observed and analyzed. Direct observation and the time evolution of open circuit potentials (OCP) measured in this work suggest that the wetting phenomena are driven not only by capillary forces but also by the electrochemistry of the reverse Boudouard reaction. A semi-quantitative model is proposed to explain the wetting dynamics of carbon. It shows that the progress of wetting is determined primarily by the production of CO at the carbon surface due to the reverse Boudouard reaction, and the OCP is therefore determined by the rate of the reverse Boudouard reaction as well as the mass transfer limitation of CO removal from the electrode. Consequently, the OCP is a function of operating temperature, ambient gas composition, and the immersed length of carbon electrode.
Oncostatin M Enhances the Antiviral Effects of Type I Interferon and Activates Immunostimulatory Functions in Liver Epithelial Cells (2009)

Oncostatin M (OSM) is released together with type I interferon (IFN) by activated dendritic cells, suggesting a concerted action of these cytokines in the biological response against infection. We found that OSM increases the antiviral effect of IFN-alpha in Huh7 hepatoma cells infected with hepatitis A or hepatitis C virus and synergizes with IFN-alpha in the induction of antiviral genes. The combination of OSM and IFN-alpha led to upregulation of both STAT1 and STAT3 together with intense and prolonged activation of STAT1, STAT3, and Jak1. OSM with or without IFN-alpha also activated p38 mitogen-activated protein kinase, which is known to enhance transcription of IFN-alpha-inducible genes. Interestingly, OSM combined with IFN-alpha strongly induced immunoproteasome genes and other genes involved in antigen processing and presentation. Moreover, OSM, alone or in combination with IFN-alpha, upregulated relevant innate immunity molecules and increased the expression of intracellular adhesion molecule 1 and interleukin-15 receptor alpha (IL-15Ralpha) in liver cells. Hepatoma cells transfected with a plasmid encoding a viral antigen were able to activate effector T cells when pretreated with IFN-alpha plus OSM but not with each cytokine separately. Also, OSM, more than IFN-alpha, augmented the ability of Huh7 cells to transpresent IL-15 to responding lymphocytes and increased the immunostimulatory activity of liver epithelial cells by presenting a short viral peptide to sensitized cytotoxic T cells. In conclusion, OSM enhances the antiviral effects of type I interferon and cooperates with it in the induction of adaptive immune responses to pathogens. These findings may have therapeutic implications.