gebhart/patrepeval huggingface dataset:
Recombination Events That Activate, Diversify, and Delete Immunoglobulin Genes (1981)

Immunoglobulin kappa light-chain diversity arises, in large part, from an array of germ-line V-region genes that undergo somatic recombination with one of four active J-region segments. The diversity provided by this combinational system is increased by a recombination mechanism that allows variation of crossover points so as to generate additional diversity at a critical region of the light chain. The elaborate mechanism for generating diversity is accompanied not only by considerable waste, in terms of unused V and J regions in a given cell, but also by a range of aberrant recombinants that fail to produce active immunoglobulin genes.
Predicting the Performance of an Electrostatic MEMS Drop Ejector (2009)

We present an analysis of an electrostatic MEMS squeezefilm dominated drop ejector. The MEMS ejector consists of a microfluidic chamber, an orifice plate, and an electrostatically driven piston positioned a few microns beneath the orifice. The piston is supported by cantilevered flexural members that act as restoring springs. To eject a drop, a voltage is applied between the orifice plate and the piston, which produces an electrostatic force that moves the piston towards the nozzle. The moving piston generates a squeeze-film pressure distribution in the gap region above it that acts to eject the drop. A prototype MEMS drop ejector has been fabricated and characterized at Sandia National Laboratories. In this presentation, we discuss the operating physics of this device, and simulate its performance using both coupled fluid/structure CFD analysis and a lumped-element electromechanical model. We study key performance parameters such as piston displacement and pressure generation.
Elevated myc expression and c-myc amplification in spontaneously occurring B lymphoid cell lines. (1987)

Recently, a minor subpopulation of murine B lymphocytes, Ly-1+ B cells, has been distinguished by its unique ontogeny, tissue distribution, and prominence in certain autoimmune and neoplastic B cell diseases. We have previously described a simple murine spleen culture system that results in the spontaneous and exclusive outgrowth of long-term Ly-1+ B cell lines (B Ly-1 cells). Here, we report that the immortal growth property of B Ly-1 cells correlates with a 10-45-fold elevation of steady-state myc RNA and 2-10-fold amplification of the c-myc locus. While c-myc amplification has been observed in malignant cell lines derived from several tissues of origin, its occurrence in lymphoid cells has not been previously reported. The consistent c-myc amplification in B Ly-1 cells may reflect a unique state of this locus in the Ly-1+ B lymphocyte lineage, and contribute to the spontaneous immortalization of this B cell population in vitro, and its apparent predilection for malignant transformation in vivo.
Data predistortion for multicarrier satellite channels using orthogonal memory polynomials (2013)

Sharing the on-board high power amplifier among different uplinked carriers (links) is attractive since it provides for economical and sustainable satellite missions. However, the non-linear characteristic of the satellite amplifier introduces intermodulation products leading to Adjacent Channel Interference (ACI), thereby degrading performance, more so for the spectrally efficient modulations. Towards supporting higher order modulations, this work proposes a novel distortion mitigation technique at the transmitter (predistortion) based on orthogonal memory polynomials and highlights its salient features: performance improvement, scalability and low complexity.
Meroterpenoids? A historical and critical review of this biogenetic determinant (2023)

In its original definition, meroterpenoids refer to substances of mixed biosynthesis including a terpenoid part. The number of compounds fulfilling this criterion is huge, and almost from the beginning, exclusions were made, more or less, explicitly stated. The concept is well accepted in the microorganism domain, where biosynthetic studies are advanced, while in the plant domain, meroterpenes and meroterpenoids randomly appear. The purpose of this article is to present and discuss miscellaneous categories of products that fulfill the definition and should be considered as meroterpenoids. Our proposal would be to retain the concept to characterize biosynthetic origins and not to consider it as a tool for classification.
Neo-Geometric Copper Nanocrystals by Competitive, Dual Surfactant-Mediated Facet Adsorption Controlling Skin Permeation (2016)

Neogeometric copper nanoparticles (CuNPs) have various applications yet its synthesis still proves to be challenging with regards to self-assembly and uniformity control. This study aimed to synthesize shape-specific CuNPs in the biomedical application of ascertaining skin permeation and retention of the CuNPs as a drug delivery system. The approach to the shape design involved the dual control of two surfactants to direct the shape organisation of the nanoparticles (NPs) while an interesting aspect of the study showed the competitive adsorption of the surfactants onto the nanocrystal facets to direct facet growth. The resulting copper nanoparticles were characterised using X-ray diffraction (XRD) and electron diffraction spectra analysis (EDS) for elemental and crystalline analysis. Thermogravimetric Analysis (TGA) identified the degradation of the surfactant coat and the synthesis of a novel copper-polymer complex and extensive transmission electron microscopy (TEM) was conducted to determine the nanoparticle morphology. Epidermal skin tissue served as the model for permeation studies of five idealistic nano-geometries and investigated its application in drug delivery with regards to cellular internalisation and transbarrier transport of the geometric CuNPs. A mechanistic consideration for shape control is discussed.
Collision-induced dissociation of proton-bound alcohol dimers by Fourier-transform mass spectrometry (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCollision-induced dissociation of proton-bound alcohol dimers by Fourier-transform mass spectrometryR. C. Burnier, R. B. Cody, and B. S. FreiserCite this: J. Am. Chem. Soc. 1982, 104, 26, 7436–7441Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/ja00390a009https://doi.org/10.1021/ja00390a009research-articleACS PublicationsRequest reuse permissionsArticle Views151Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
3636 Gait Analysis Using Acceleration and Gyro Sensors (2008)

This work proposes a method that can measure the three-dimensional positions of joint centers for hip, knee and ankle using wearable acceleration and gyro sensors. Healthy volunteers wore small sensor unit that included a tri-axis acceleration sensor and three single axis gyro sensors. Acceleration data from acceleration sensors and angular velocity data from gyro sensors to were used to estimate joint angles of the hip and knee. The joint angles along with the volunteers' body measurements were used to calculate positions of hip, knee and ankle joint. Flexion-extension angle and internal-external rotation joint angle of hip and the flexion joint angle of knee were calculated using this method was compared with that of a reference motion capture system. Correlation coefficients were 0.888 for the flexion-extension joint angle of hip, 0.721 for the internal-external rotation joint angle of hip, and 0.924 for the flexion joint angle of knee. From these results this method can accurately measure gait.
Single ultrafast diffusive conduction based optoelectronic switch for multi-channel operation (2005)

For multi-channel optical switching, we report single ultrafast diffusive conduction based optoelectronic switches that accommodate >100 optical channels (with 2,000 mm/sup -2 /channel density and <10% crosstalk), on 300/spl mu/m/spl times/300/spl mu/m devices with switching bandwidths of >50 GHz.
Growth Temperature Dependence of µc-Si:H Films Sputtered with Hydrogen Gas (1990)

Hydrogenated microcrystalline Si films were deposited by RF sputtering with hydrogen gas in the temperature range of 100–400°C. X-ray diffraction, Raman spectroscopy, and FT/IR absorption measurements revealed that grain size and (110) orientation ratio increased, the growth rate and bonded hydrogen content decreased, and the Raman shift approached that of crystalline Si as the substrate temperature was raised. The temperature dependence of the characteristics suggested that hydrogen desorption together with Si elements from the growing surface and the growth temperature play an important role in determining the characteristics.
High‐Performance Reflective Electrochromic Device by Integrating White Reflector and High Optical Density Electrochromic System (2019)

Abstract This paper reports an efficient reflective electrochromic device (ECD) by integrating a highly reflective micro‐porous titanium dioxide–based white reflector film and an optimized transparent to black convertible electrochromic (EC) system. This reflective ECD can reflect almost 58.5% of light in the white state and 4.7% in the dark black state at 550 nm. Similarly, it also exhibits a very high ambient contrast ratio of 38:1 under office ambient light condition and good driving stability of about 83% in the white state (0 V) and 98% in the black state (1.7 V) after 10 000 driving cycles. In addition, the EC system is optimized by selecting good proton generator and suitable solvent for better coloration property as well as a low driving voltage via lactone ring opening reaction of leuco dye and supporting polymer for high optical density through suppressing the movement of oxidized leuco dye to the electrode. An ECD with the optimized EC system shows significant improvement in average optical density from 0.62 to 1.9 (at 400 to 700 nm) and faster switching speeds of about 1.6 s.
Use of Precision-Cut Tissue Slices as a Translational Model to Study Host-Pathogen Interaction (2021)

The recent increase in new technologies to analyze host-pathogen interaction has fostered a race to develop new methodologies to assess these not only on the cellular level, but also on the tissue level. Due to mouse-other mammal differences, there is a desperate need to develop relevant tissue models that can more closely recapitulate the host tissue during disease and repair. Whereas organoids and organs-on-a-chip technologies have their benefits, they still cannot provide the cellular and structural complexity of the host tissue. Here, precision cut tissue slices (PCTS) may provide invaluable models for complex <i>ex-vivo</i> generated tissues to assess host-pathogen interaction as well as potential vaccine responses in a "whole organ" manner. In this mini review, we discuss the current literature regarding PCTS in veterinary species and advocate that PCTS represent remarkable tools to further close the gap between target identification, subsequent translation of results into clinical studies, and thus opening avenues for future precision medicine approaches.
The Energy Efficiencyof IRAM Architectures (1997)

Portable systems demand energy effi ciency in order to maximize battery life. IRAM architectures, which combine DRAM and a processor on the same chip in a DRAM process, are more energy efficien t than conventional systems. The high density of DRAM permits a much larger amount of memory on-chip than a traditional SRAM cache design in a logic process. This allows most or all IRAM memory accesses to be satisfie d on-chip. Thus there is much less need to drive high-capacitance off-chip buses, which contribute significa ntly to the energy consumption of a system. To quantify this advantage we apply models of energy consumption in DRAM and SRAM memories to results from cache simulations of applications reflec tive of personal productivity tasks on low power systems. We fi nd that IRAM memory hierarchies consume as little as 22% of the energy consumed by a conventional memoryhierarchy for memoryintensive applications, while delivering comparable performance. Furthermore, the energy consumed by a system consisting of an IRAM memory hierarchy combined with an energy efficien t CPU core is as little as 40% of that of the same CPU core with a traditional memory hierarchy.
High Power Waveguide Ge/Si Photodiodes (2010)

Abstract not Available.
PATHOGENETIC ROLE OF VASCULAR ANGIOTENSIN‐CONVERTING ENZYME IN THE SPONTANEOUSLY HYPERTENSIVE RAT (1991)

1. This study was undertaken to examine the possibility that the level of angiotensin-converting enzyme (ACE) increases in vascular tissue, and that this may participate in the pathogenesis of hypertension in spontaneously hypertensive rat (SHR). 2. In SHR, at the established hypertensive stage, the prolonged antihypertensive effect induced by a single oral dose of spirapril was closely correlated to the long-lasting inhibition of ACE in aortae and mesenteric arteries. In contrast, ACE in plasma, lung, heart and kidney recovered from inhibition faster than in vessels. 3. Prolonged daily oral treatment of SHR with spirapril, initiated at the age of 8 weeks and continued for 8 weeks, prevented the development of hypertension with concomitant decrease in aortic ACE activity. Blood pressure continued to be suppressed after the drug was withdrawn, as did the aortic ACE activity. 4. Spontaneously hypertensive rats developed hypertension with age as well as with the increase in aortic ACE activity which became higher with age than that of Wistar-Kyoto (WKY) normotensive control rats. On the contrary, ACE activity in plasma and lung of SHR was substantially lower than that of WKY at any age from 4 to 20 weeks old. Brain ACE activity of SHR did not differ from that of WKY at any age. Aged SHR showed the lower enzyme activity in the kidney compared with that of age-matched WKY. 5. Our results support the hypothesis that increased vascular ACE may play an essential role in the development and maintenance of hypertension in SHR.
Photoluminescence Spectra of ZnO Films Doped with Li and Cl Atoms (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
A Compact Octave Tunable Switched-Power-Combining PA (2021)

This paper presents a switched-power-combining RF power amplifier (PA) architecture, using evanescent-mode resonators as input splitters and output combiners. The input resonator also provides proper input matching to the transistor, eliminating the need for an input matching network, which reduces the overall size of the PA. The external couplings into the resonators are switchable to allow for activating one, two, or all three sub-PAs, depending on the power requirement. This results in a higher Output Back-off (OBO) efficiency, compared to a single PA. The presented concepts for the proposed architecture are supported by theoretical analysis and experimental validation. The implemented PA is based on Class-E sub-PAs, operates in the 1.2–2.4 GHz range, provides 36–40 dBm output power, and occupies an area of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$41\times 82$ </tex-math></inline-formula> mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Compared to the state-of-the-art amplifiers operating at this frequency range, this resembles an average of 80% reduction in size.
Time Resolved Fano Resonances (2005)

Recent advances in the generation of sub-fs extreme ultraviolet pulses and attosecond metrology have opened up the possibility to trace the time evolution of electronic wave packets inside atoms in pump-probe experiments. We investigate the feasibility of observing the buildup of a Fano resonance in the time domain by attosecond streaking techniques. A time-resolved resonance is initialized by a sub-fs extreme ultraviolet-pump pulse in the presence of a synchronized phase-controlled probe laser pulse. The time evolution of the coherent superposition of resonant state and continuum is mapped onto a modulation of the electron spectrum as a function of the time delay between pump and probe pulse. (super-)Coster-Kronig transitions with lifetimes of approximately 400 asec( are identified as prime candidates.
Validación de la punción aspiración con aguja fina (PAAF) en el diagnóstico de linfadenitis tuberculosa en pacientes con infección por el virus de la inmunodeficiencia humana (VIH) (2009)

Introducción: la punción aspiración aguja fina (PAAF) de ganglio linfático es una técnica sencilla, rápida y de bajo costo para la obtención de muestras para diagnóstico. Objetivo: el objetivo del estudio fue validar la PAAF en el diagnóstico de linfadenitis tuberculosa (TB) en pacientes infectados por el virus de la inmunodeficiencia humana (VIH), utilizando como "gold standard" el cultivo de Mycobacterium tuberculosis en biopsia ganglionar o la histopatología más la respuesta al tratamiento específico. Material y método: estudio clínico-patológico prospectivo. Se incluyeron pacientes VIH infectados, previo consentimiento informado, mayores a 18 años, con adenomegalias superficiales mayores a 2 cm, asistidos en la Cátedra de Enfermedades Infecciosas entre octubre de 2004 y diciembre de 2006. Se realizó PAAF y biopsia del mismo ganglio. En las muestras citológicas e histopatológicas se realizaron tinciones habituales, Ziehl-Neelsen y cultivos para micobacterias. Se definió como citología sugestiva de linfadenitis TB: 1) linfadenitis reactiva con necrosis; 2) linfadenitis reactiva con células epitelioides y/o macrófagos y/o células gigantes multinucleadas; con o sin bacilos ácido-alcohol resistentes en el directo con tinción de Ziehl-Neelsen. Resultados: de 30 pacientes incluidos, 23 correspondieron a una TB ganglionar. En los siete pacientes restantes la PAAF descartó el diagnóstico de TB en seis, evitando tratamientos innecesarios, e indicando estudio histológico para diagnóstico definitivo. La sensibilidad, especificidad, valor predictivo positivo y valor predictivo negativo de la PAAF para el diagnóstico de linfadenitis TB fue de 95%, 86%, 95% y 86%, respectivamente. El coeficiente de concordancia de Kappa entre ambos procedimientos fue de 90%. Conclusiones: la PAAF de ganglio linfático en pacientes VIH tiene un elevado rendimiento como técnica diagnóstica de TB ganglionar. A su vez permite seleccionar qué pacientes requieren biopsia ganglionar para diagnóstico definitivo, evitando la realización sistemática de la misma en todos los pacientes con adenomegalias.
Cystatin B Deficiency Sensitizes Neurons to Oxidative Stress in Progressive Myoclonus Epilepsy, EPM1 (2009)

The progressive myoclonus epilepsies, featuring the triad of myoclonus, seizures, and ataxia, comprise a large group of inherited neurodegenerative diseases that remain poorly understood and refractory to treatment. The Cystatin B gene is mutated in one of the most common forms of progressive myoclonus epilepsy, Unverricht-Lundborg disease (EPM1). Cystatin B knockout in a mouse model of EPM1 triggers progressive degeneration of cerebellar granule neurons. Here, we report impaired redox homeostasis as a key mechanism by which Cystatin B deficiency triggers neurodegeneration. Oxidative stress induces the expression of Cystatin B in cerebellar granule neurons, and EPM1 patient-linked mutation of the Cystatin B gene promoter impairs oxidative stress induction of Cystatin B transcription. Importantly, Cystatin B knockout or knockdown sensitizes cerebellar granule neurons to oxidative stress-induced cell death. The Cystatin B deficiency-induced predisposition to oxidative stress in neurons is mediated by the lysosomal protease Cathepsin B. We uncover evidence of oxidative damage, reflected by depletion of antioxidants and increased lipid peroxidation, in the cerebellum of Cystatin B knock-out mice in vivo. Collectively, our findings define a pathophysiological mechanism in EPM1, whereby Cystatin B deficiency couples oxidative stress to neuronal death and degeneration, and may thus provide the basis for novel treatment approaches for the progressive myoclonus epilepsies.
Polymeric drug delivery systems for encapsulation hydrophobic drug (2013)

International audience
Compressive Sensing Over Networks (2010)

In this paper, we demonstrate some applications of compressive sensing over networks. We make a connection between compressive sensing and traditional information theoretic techniques in source coding and channel coding. Our results provide an explicit trade-off between the rate and the decoding complexity. The key difference of compressive sensing and traditional information theoretic approaches is at their decoding side. Although optimal decoders to recover the original signal, compressed by source coding have high complexity, the compressive sensing decoder is a linear or convex optimization. First, we investigate applications of compressive sensing on distributed compression of correlated sources. Here, by using compressive sensing, we propose a compression scheme for a family of correlated sources with a modularized decoder, providing a trade-off between the compression rate and the decoding complexity. We call this scheme Sparse Distributed Compression. We use this compression scheme for a general multicast network with correlated sources. Here, we first decode some of the sources by a network decoding technique and then, we use a compressive sensing decoder to obtain the whole sources. Then, we investigate applications of compressive sensing on channel coding. We propose a coding scheme that combines compressive sensing and random channel coding for a high-SNR point-to-point Gaussian channel. We call this scheme Sparse Channel Coding. We propose a modularized decoder providing a trade-off between the capacity loss and the decoding complexity. At the receiver side, first, we use a compressive sensing decoder on a noisy signal to obtain a noisy estimate of the original signal and then, we apply a traditional channel coding decoder to find the original signal.