gebhart/patrepeval huggingface dataset:
Modeling of the Starting Performance of Large Solid-Pole Synchronous Motors Using Equivalent Circuit Approach (2009)

We present a method of modeling the starting performance of large solid pole synchronous motors based on an equivalent circuit approach. In this approach, the solid rotor body is assumed to have two sets of separate virtual windings. Therefore, the two-axis theory can be used for the solid pole synchronous motor. We derived parameters associated with the solid-pole, together with their transformation coefficients. We simulated the starting performance and validated the results by testing a 15 000 hp, 13.2 kV, four-pole solid-pole synchronous motor.
Mannosidase activity of EDEM1 and EDEM2 depends on an unfolded state of their glycoprotein substrates (2018)

Extensive mannose trimming of nascent glycoprotein N-glycans signals their targeting to endoplasmic reticulum-associated degradation (ERAD). ER mannosidase I (ERManI) and the EDEM protein family participate in this process. However, whether the EDEMs are truly mannosidases can be addressed only by measuring mannosidase activity in vitro. Here, we reveal EDEM1 and EDEM2 mannosidase activities in vitro. Whereas ERManI significantly trims free N-glycans, activity of the EDEMs is modest on free oligosaccharides and on glycoproteins. However, mannosidase activity of ERManI and the EDEMs is significantly higher on a denatured glycoprotein. The EDEMs associate with oxidoreductases, protein disulfide isomerase, and especially TXNDC11, enhancing mannosidase activity on glycoproteins but not on free N-glycans. The finding that substrate unfolded status increases mannosidase activity solves an important conundrum, as current models suggest general slow mannose trimming. As we show, misfolded or unfolded glycoproteins are subject to differentially faster trimming (and targeting to ERAD) than well-folded ones.
In situ Raman spectroscopy for the characterization of MoVW mixed oxide catalysts (2002)

Abstract In situ Raman spectroscopy was used to characterize the synthesis and activation steps of mixed metal oxide catalysts starting from the mixed solutions, through subsequent drying and activation procedures, to the catalytic propene partial oxidation reaction. Comparison with Raman spectra recorded for defined, well‐crystallized reference oxides allowed the assignment of the spectra obtained during the catalyst preparation to certain oxides, such as Mo 5 O 14 . Especially the latter oxide phase is relevant for selective partial oxidation catalysis. The selectivity for partial oxidation products could be improved between two‐ and three‐fold when the amount of Mo 5 O 14 ‐type oxide increased. This phase forms from mixtures of molybdenum and tungsten and from mixtures of molybdenum, tungsten and vanadium, but not from binary mixtures of molybdenum and vanadium with high vanadium concentrations. Tungsten and vanadium play an important role as structural promoters in the formation and stabilization of this oxide and for high catalytic activity. A resonance Raman effect was proved for reduced molybdenum oxides due to resonant coupling of the exciting laser to the IVCT transitions between fivefold‐coordinated Mo 5+ and sixfold‐coordinated Mo 6+ . This resonance enhancement renders possible the in situ characterization of operating, reduced molybdenum oxide catalysts. In contrast to the Mo 5 O 14 ‐type phase, MoO 3− x exhibits a high selectivity to total oxidation, and it even becomes re‐oxidized during propene partial oxidation. These different catalytic properties of MoO 3− x and the Mo 5 O 14 ‐type oxide led to the development of a structure–activity relationship which explains the behavior of industrial catalysts. A model is proposed on the basis of a bond order–Raman wavenumber relationship, which explains the different selectivities of these two oxides in terms of metal–oxygen bond strengths, i.e. oxygen basicity and oxygen lability, respectively. Copyright © 2002 John Wiley &amp; Sons, Ltd.
Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300 (2012)

Capturing a coactivator, naturally: the natural products sekikaic acid and lobaric acid, isolated after a high-throughput screen of a structurally diverse extract collection, effectively target the dynamic binding interfaces of the GACKIX domain of the coactivator CBP/p300. These molecules are the most effective inhibitors of the GACKIX domain yet described and are uniquely selective for this domain.
Optical modulation in thin films (1974)

Thin-film optical modulators may find widespread application in communications and information processing systems because of their high bandwidth, low electrical power requirements, and compatibility with other thin-film components. A thin-film modulator consists of a dielectric waveguide and an appropriate electrode structure. An applied electric or magnetic field or a traveling acoustic wave alters the dielectric tensor of the film and/or substrate in such a manner as to change the amplitude, phase, or frequency of the guided light wave. Materials have included semiconducting III–V and II–VI compounds, LiNbO3, and nitrobenzine liquid for electro-optic devices, garnets for magneto-optic devices, and glass films on quartz and LiNbO3 substrates for acousto-optic devices. This paper will review the theory of dielectric waveguides and input-output coupling as well materials, fabrication techniques, and performance characteristics for the various types of thin-film modulators.
Identifying performance bottlenecks in software data planes for cloud-based NFV services (2018)

Network Function Visualization (NFV) is transforming the market for computer networks. Most proposed NFV solutions have been implemented and tested in cloud computing environments. In this context, both hardware and software-based features have been used to improve the performance of Virtual Network Functions (VNFs) by speeding up packet processing. However, there are still essential research challenges that need to be tackled to provide better performance experiences for NFV Services, such as detecting and diagnosing performance bottlenecks. However, due to the characteristics inherited from both Cloud and NFV environments, the detection and diagnose of performance problems is a complex task. In this work, we proposed PerfChecker, a monitoring tool that aims at detecting and diagnosing performance bottlenecks in Cloud-based NFV environments. We implemented a PerfChecker prototype for OpenStack and performed some experiments demonstrating that it can assist the cloud infrastructure operator to improve the performance of NFV services.
Prevalence of challenge‐proven IgE‐mediated food allergy in infants in the Barwon Region, Victoria, Australia (2015)

A recent study found that approximately 10% of 1 year old infants living in Melbourne, Australia have challenge proven food allergy; which is the highest reported rate in the world. The prevalence of IgE-mediated food allergy among Australian infants living outside a major metropolitan city has not been measured. To determine the prevalence of IgE-mediated food allergy in a population-derived cohort of infants aged 1 year from the Barwon Region, in the south east of Australia. The Barwon region, located approximately 100 km south of Melbourne, is centred around the city of Geelong and has metropolitan, rural and coastal communities. The Barwon Infant Study (BIS) is a population-derived birth cohort study (n = 1069 infants). As part of the 12 month review infants undergo skin prick testing to five foods: cow's milk, raw egg, peanut, cashew and sesame. Those with any detectable wheal size are offered a formal in-hospital oral food challenge using a validated protocol to determine their clinical allergy status. To date 671/717 (93%) of infants who have completed their one-year BIS review have undergone skin prick testing. Overall 88/671 (13.1%; 95% CI, 10.6-15.9) were sensitized to one or more of the five foods: raw egg 9.5% (95 % CI, 7.4-12.0), peanut 3.2% (95% CI, 2.0-4.9), cashew 2.2% (95% CI, 1.2-3.6), cow's milk 1.1% (95% CI, 0.0-2.0) and sesame 0.4% (95% CI, 0.004-1.3). 67 of 88 (76%) infants with allergic sensitization have undergone a food challenge. Among those challenged, the overall rate of proven food allergy is 43/67 (64%; 95% CI, 51.5-75.5). For each specific food the rates are: raw egg 37 (68.5%; 95% CI, 54.4-80.4), peanut 6 (46.1%; 95% CI, 19.2-74.8), cashew 1 (16.6%; 95% CI, 0.4-64.1), sesame 1 (50%; 95% CI, 12.5-98.7) and cow's milk 2 (50%; 95%CI, 6.7-93.2). Based on these preliminary figures the estimated prevalence of challenge proven food allergy among the BIS cohort is 6.4% (95% CI, 4.6-8.5). The estimated allergy rates for specific foods are: raw egg 5.5% (95 % CI, 3.9-7.5); peanut 0.8% (95% CI, 0.3-1.9); cashew 0.1% (95% CI, 0.00-0.8); sesame 0.1% (95%CI, 0.00-0.8) and cow's milk 0.2% (95% CI, 0.0-1.0). Preliminary results suggest that the prevalence of food allergy in a regional centre in Australia may be less than in a major metropolitan centre such as Melbourne. Further investigation is underway to verify this regional difference and to identify contributing factors.
Drug interaction potential of toremifene andN-desmethyltoremifene with multiple cytochrome P450 isoforms (2011)

Toremifene is an effective agent for the treatment of breast cancer in postmenopausal women and is being evaluated for its ability to prevent bone fractures in men with prostate cancer taking androgen deprivation therapy. Due to the potential for drug-drug interactions, the ability of toremifene and its primary circulating metabolite N-desmethyltoremifene (NDMT) to inhibit nine human cytochrome P450 (CYP) enzymes was determined using human liver microsomes. Induction of CYP1A2 and 3A4 by toremifene was also investigated in human hepatocytes. Toremifene did not significantly inhibit CYP1A2 or 2D6. However, toremifene is a competitive inhibitor of CYP3A4, non-competitive inhibitor of CYP2A6, 2C8, 2C9, 2C19 and 2E1 and mixed-type inhibitor of CYP2B6. CYP inhibition by NDMT was similar in magnitude to toremifene. Toremifene did not induce CYP1A2 but increased CYP3A4 monooxygenase activity and gene expression in drug-exposed human primary hepatocytes. Although clinical doses of toremifene produce steady state exposures to toremifene and NDMT that may be sufficient to cause pharmacokinetic drug-drug interactions with other drugs metabolised by CYP2B6, CYP2C8, CYP3A4, CYP2C9 and CYP2C19, these data indicate that toremifene is unlikely to play a role in clinical drug-drug interactions with substrate drugs of CYP1A2 and CYP2D6.
The cellular immunology of multiple sclerosis (1999)

Abstract Multiple sclerosis (MS) is a neurological disease that affects the central nervous system (brain and spinal cord) resulting in debilitating motor and sensory dysfunction. Its mean age of onset is 30 years and, with the exception of trauma, MS remains the most frequent cause of neurological disabilities for young adults. The disease is highly variable in its onset and progression. It may not be easily diagnosed, at least in its earliest stages. Significant disability is a hallmark of MS. Indeed, up to 50% of patients require walking aids and 10% are wheelchair-bound at 15 years after an initial diagnosis. Clinical features include deficits in sensory (parasthesias and numbness), motor (difficulties with fine movements and gait), balance, bladder, and sexual functions. Although the etiology for MS is not yet known, it is thought to be related to microbial, genetic, and/or environmental factors. Pathologically, MS is characterized by inflammation. An influx of mononuclear cells occurs through a disrupted blood–brain barrier into an immune-privileged central nervous system. The secretion of a variety of inflammatory cytokines and chemokines from glial cells leads to loss of myelin, disruption of oligodendrocyte integrity, and axonal loss. These events, in large measure, affect progressive neural atrophy. How brain inflammatory activities affect transendothelial migration of leukocytes into the brain and alter the process of myelination are the focal points for MS research activities. J. Leukoc. Biol. 65: 444-452; 1999.
Antigens for CD4 and CD8 T Cells in Tuberculosis (2014)

Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (MTB), represents an important cause of morbidity and mortality worldwide for which an improved vaccine and immunodiagnostics are urgently needed. CD4(+) and CD8(+) T cells play an important role in host defense to TB. Definition of the antigens recognized by these T cells is critical for improved understanding of the immunobiology of TB and for development of vaccines and diagnostics. Herein, the antigens and epitopes recognized by classically HLA class I- and II-restricted CD4(+) and CD8(+) T cells in humans infected with MTB are reviewed. Immunodominant antigens and epitopes have been defined using approaches targeting particular TB proteins or classes of proteins and by genome-wide discovery approaches. Antigens and epitopes recognized by classically restricted CD4(+) and CD8(+) T cells show extensive breadth and diversity in MTB-infected humans.
Novel Micro-CT contrast agent for quantitative virtual 3D histology of mineralized and soft skeletal tissues (2017)

status: Published
Design of a Novel Fab‐Like Antibody Fragment with Enhanced Stability and Affinity for Clinical use (2021)

With increasing interest in applying recombinant monoclonal antibodies (mAbs) in human medicine, engineered mAb fragments with reduced size and improved stability are in demand to overcome current limitations in clinical use. Herein, a novel Fab-like antibody fragment generated via an in silico-based engineering approach where the CH1 and CL domains of Fab are replaced by the IgG1 CH3 domains is described. This construct, designated as FabCH3, maintains the natural N-terminus and C-terminus of IgG antibody, can be expressed at a high level in bacterial cells and, importantly, exhibits much higher stability and affinity than the parental Fab when tested in a mesothelin-specific Fab m912, as well as a vascular endothelial growth factor A (VEGFA)-specific Fab Ranibizumab (in vivo). The high-resolution crystal structures of m912 FabCH3 and m912 Fab are determined, and the comparative analysis reveals more rigid structures in both constant domains and complementarity-determining regions of FabCH3, explaining its enhanced stability and affinity. Overall, the stabilized FabCH3 described in this report provides a versatile platform for engineering Fab-like antibody fragments with higher stability and antigen-binding affinity that can be used as a distinct class of antibody therapeutics.
Characterization of an Electrospray Ion Source as a Controlled-Current Electrolytic Cell (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of an Electrospray Ion Source as a Controlled-Current Electrolytic CellGary J. Van Berkel and Feimeng. ZhouCite this: Anal. Chem. 1995, 67, 17, 2916–2923Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/ac00113a028https://doi.org/10.1021/ac00113a028research-articleACS PublicationsRequest reuse permissionsArticle Views1102Altmetric-Citations163LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Geometric conformity analysis for automated fabrication processes generating ruled surfaces: demonstration for contour crafting (2009)

Purpose The purpose of this paper is to present an introduction to geometric conformity principles for examining the geometric deviation between the desired (designed) and the fabricated surfaces which may be generated by a class of surface ruling fabrication processes such as flank milling, wire electrical discharge machining (WEDM), and contour crafting (CC). Design/methodology/approach In general, it is computationally challenging to calculate error approximation based on points. This paper proposes methods that efficiently calculate error approximation based on curve, surface area, and volume. Findings This paper derives the equations for calculating the ruled surface areas and the volume of 3D slices in 3D object models. One may use the difference of surface areas or volumes to determine the extent of the global conformity of the ruled surfaces. Additionally, local conformity analysis through calculating curve deviation has been introduced to improve the reliability of the global conformity analysis. Research limitations/implications The research results apply only to fabrication processes that generate ruled surfaces. There are, however, numerous applications in which ruled surfaces are generated, such as WEDM, any numerical control machining which uses cylindrical or conical cutting bits, and CC. Practical implications The research results presented will be applicable to fabrication processes such as flank milling, WEDM, and CC. Originality/value All developments presented are original. Also, CC, which is a candidate process for the developments presented in the paper, has been invented and developed by the authors.
Chinese Family Law and Social Change in Historical and Comparative Perspective. Edited by David C. Buxbaum. Seattle: University of Washington Press (Asian Law Series No. 3), 1978. viii, 553 pp. Notes, Tables, Bibliography, Glossary, Index. $20.00. (1980)

Chinese Family Law and Social Change in Historical and Comparative Perspective. Edited by David C. Buxbaum. Seattle: University of Washington Press (Asian Law Series No. 3), 1978. viii, 553 pp. Notes, Tables, Bibliography, Glossary, Index. $20.00. - Volume 39 Issue 2
Room temperature continuous wave operation of 671 nm wavelength GaInAsP/AlGaAs VSIS lasers (1990)

Room-temperature continuous-wave (CW) operation of a liquid-phase epitaxy (LPE)-grown GaInAsP/AlGaAs laser that uses a V-channel substrate inner stripe (VSIS) structure to obtain current confinement and transverse mode control is discussed. The threshold current and lasing wavelength were 77 mA and 671 nm, respectively, and the temperature dependence of the threshold current was such that the characteristic temperature was 75 K.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Pattern fidelity in nanoimprinted films using CD-SAXS (2005)

The primary measure of process quality in nanoimprint lithography (NIL) is the fidelity of pattern transfer, comparing the dimensions of the imprinted pattern to those of the mold. As a potential next generation lithography, NIL is capable of true nanofabrication, producing patterns of sub-10 nm dimensions. Routine production of nanoscale patterns will require new metrologies capable of non-destructive dimensional measurements of both the mold and the pattern with sub-nm precision. In this article, a rapid, non-destructive technique termed Critical Dimension Small Angle X-ray Scattering (CD-SAXS) is used to measure the cross sectional shape of both a pattern master, or mold, and the resulting imprinted films. CD-SAXS data are used to extract periodicity as well as pattern height, width, and sidewall angles. Films of varying materials are molded by thermal embossed NIL at temperatures both near and far from the bulk glass transition (TG). The polymer systems include a photoresist, representing a mixture of a polymer and small molecular components, and two pure homopolymers. Molding at low temperatures (T-TG < 40°C) produces small aspect ratio patterns that maintain periodicity to within a single nanometer, but feature large sidewall angles. While the pattern height does not reach that of the mold until very large imprinting temperatures (T-TG &#8776; 70°C), the pattern width of the mold is accurately transferred for T-TG > 30°C. In addition to obtaining basic dimensions, CD-SAXS data are used to assess the origin of loss in pattern fidelity.
Capture in the metabolic arena: co-selection of gamma and deltaretrovirus envelope glycoproteins and their receptors (2009)

International audience
Light emission between 2 and 4 &#x00B5;m: Innovative active region designs for InP- and GaSb-based devices (2013)

This work shows different approaches to cover the spectral range from 2 to 4 μm with active regions based on InP and GaSb for devices suitable as light sources for gas-sensing applications. For shorter wavelengths up to 2.3 μm type-I InP-based quantum wells with rectangular and triangular shape are the preferred choice, beyond that GaSb-based type-I active regions were studied to cover the wavelengths up to 4 μm. An alternative method is implementing type-II structures on InP to exploit the advantages of this well-known material system for device fabrication. For the different methods device designs, growth issues and applications will be discussed.
Methplotlib: analysis of modified nucleotides from nanopore sequencing (2020)

Supplementary data are available at Bioinformatics online.
P09-13. Structure of HIV-1 gp41 interactive region: layered architecture and basis of conformational mobility (2009)

Background Crystal structures of unliganded, CD4-bound, and antibody-bound gp120 core show large conformational rearrangements upon ligand binding. Moreover, cryo-EM tomograms of the HIV-1 viral spike (gp120/gp41) also show large ligand-induced shifts in gp120 orientation. Conformational change is one mechanism that HIV-1 has developed to evade the host immune response. We hypothesized that the key to understanding this mobility resided in the critical gp41-interactive region of gp120. However, previously determined core structures all contained deletions of the gp41-interactive region.
Specificity determinants for chemokine recognition identified using eotaxin‐MCP‐1 chimeras (2004)

To identify the elements of two chemokines [monocyte chemoattractant protein-1 (MCP-1) and eotaxin] that control their differential recognition by their respective receptors (CCR2 and CCR3), we have studied the receptor interactions of MCP-1-eotaxin chimeras. Each receptor was found to exhibit a distinct binding preference for proteins containing the amino-terminal region of the cognate chemokine for that receptor. However, other elements dictating chemokine preference were different for the two receptors. In some cases, the influence of replacing a particular region was dependent on the identities of neighboring regions, indicating a complex network of cooperative and/or compensating interactions.