gebhart/patrepeval huggingface dataset:
Pure red cell aplasia due to parvovirus B19 infection in solid organ transplantation (1997)

Human parvovirus B19 disease is an infrequent but recognized rare cause of anemia in immunocompromised patients. A few cases of parvovirus B19 infections have been reported in transplant recipients, of those only four patients underwent renal transplantation. The primary immunosuppressive therapy in these patients included prednisone with either cyclosporine or tacrolimus. In one patient the disease was self-limiting, while in three others the hematocrit improved following 10-15 d of treatment with commercial intravenous immunoglobulin (IVIG). Herein, we report the fifth case of pure red cell aplasia due to parvovirus B19 infection in a renal transplant recipient who responded to a 5-d course of IVIG. To our knowledge, this is the first case of parvovirus B19 infection in a patient with solid-organ transplantation whose immunosuppressive regimen included both mycophenolate mofetil and tacrolimus and in whom an excellent clinical response was achieved with a short course of IVIG infusion.
LOS Delay Estimation using Super Resolution Deep Neural Networks for Precise Positioning (2020)

Precise positioning in 5G that can enable a wide variety of new use cases. We investigate the problem of accurate line-of-sight (LOS) delay estimation of an observed wireless channel using deep neural networks (NN). These delay estimates are the primary building block for deriving accurate position estimates. Our work proposes a custom super-resolution NN that exploits the properties of the wireless channel to guide the NN design. We compare against traditional algorithms used for LOS detection and show that the proposed NN shows excellent performance in the presence of weak LOS signals and dense multipath; scenarios that are challenging for traditional signal processing algorithms.
Levels of glycosaminoglycans in the cerebrospinal fluid of healthy young adults, surrogate-normal children, and Hunter syndrome patients with and without cognitive impairment (2015)

In mucopolysaccharidoses (MPS), glycosaminoglycans (GAG) accumulate in tissues. In MPS II, approximately two-thirds of patients are cognitively impaired. We investigated levels of GAG in cerebrospinal fluid (CSF) in different populations from four clinical studies (including NCT00920647 and NCT01449240). Data indicate that MPS II patients with cognitive impairment have elevated levels of CSF GAG, whereas those with the attenuated phenotype typically have levels falling between those of the cognitively affected patients and healthy controls.
Why do stars twinkle, and do they twinkle on Mars? (2012)

The question “Why do stars twinkle?” is typically given a superficial answer that satisfies most people. However, as is often the case for physics-related questions about everyday phenomena, a more complete explanation is surprisingly rich and somewhat subtle.
Applying Scenario Optimization to Portfolio Credit Risk (2001)

Standard market risk optimization tools, based on assumptions of normality, are ineffective for evaluating credit risk. In this article, the authors develop three scenario optimization models for portfolio credit risk. They first create the trading risk profile and find the best hedge position for a single asset or obligor. The second model adjusts all positions simultaneously to minimize the regret of the portfolio subject to general linear restrictions. Finally, a credit risk‐return efficient frontier is constructed using parametric programming. While scenario optimization of quantile‐based credit risk measures leads to problems that are not generally tractable, regret is a relevant and tractable measure that can be optimized using linear programming. The three models are applied to optimizing the risk‐return profile of a portfolio of emerging market bonds.
Molecular Characterization and in Vitro Biological Activity of Placentin, a New Member of the Insulin Gene Family (1996)

Insulin and insulin-like growth factors belong to a family of polypeptides involved in essential physiological processes. Placentin, a new member of the insulin family, was recently identified as a 139-amino acid open reading frame from a cDNA clone isolated from a subtracted library of first trimester human placenta. Tris/Tricine/SDS-polyacrylamide gel electrophoresis and immunoblot analyses of histidine-tagged recombinant placentin indicate that it is composed of two peptide chains of apparent molecular masses of 4 and 13 kDa. Conditioned media produced by recombinant expression of placentin cDNA in the placental 3AsubE cell line were assayed for biological activity and found to stimulate tyrosine phosphorylation and DNA synthesis. While these effects closely mimicked those of insulin, they were not mediated by the insulin receptor as shown by the lack of tyrosine phosphorylation of this receptor upon placentin treatment. Moreover, in cytotrophoblast primary culture, production of chorionic gonadotropin, a marker of trophoblast differentiation, was increased upon treatment with placentin-conditioned media, while unaffected by insulin. These results suggest that placentin might participate in the cellular proliferation and/or differentiation processes during placental development.
Preclinical In Vitro and In Vivo Evidence Support a Therapeutic Role for the CD70 Directed Monoclonal Antibody (SGN-70) in Waldenstrom’s Macroglobulinemia (WM). (2006)

Abstract Introduction: WM is a B-cell disorder characterized by bone marrow (BM) infiltration of lymphoplasmacytic cells (LPC), along with excess mast cells (MC) which support the growth and survival of BM LPC through multiple TNF-family ligands including CD40L, APRIL and BLyS/BAFF. Importantly, BM LPC stimulate cell surface expression of TNF-family ligands through release of sCD27 which induces CD70 on MC. We therefore have sought the development of agents which could target CD27-CD70 interactions. As such, we examined the therapeutic potential of directly targeting CD70 using the fully humanized monoclonal antibody SGN-70 (Seattle Genetics, Inc., Bothell WA). Methods-Results: As part of these studies, we used flow cytometric analysis to evaluate the expression of CD70 on primary WM patient BM LPC and MC, as well as 2 WM cell lines (BCWM.1 and WM-WSU). These studies demonstrated cell surface expression of CD70 on BM LPC and MC from 20/26 (77%) and 10/11 (90%) WM patients, respectively. We next assessed the ability of the SGN-70 antibody to eradicate primary WM LPC (n=5) and WM cell lines by assessing for direct induction of apoptosis, complement dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC) as well as induction of TNF family ligands on primary WM MC and the LAD2 MC line. Following incubation of WM LPC with SGN-70 (0.01–20 μg/ml), no direct induction of apoptosis or CDC activity was observed. However, SGN-70 mediated significant dose-dependent ADCC against WM LPC and MC at concentrations of 0.1–20 ug/ml. Importantly, SGN-70 blocked sCD27-induced expression of CD40L and APRIL on primary WM MC and LAD2 MC. To further evaluate the therapeutic potential of SGN-70 in an in vivo model, SCID-hu mice bearing BCWM.1 WM cells were treated with SGN-70 (1 mg/kg, i.p., qOD) Serum human IgM and sCD27 levels were measured by ELISA to monitor for tumor engraftment and disease progression. SGN-70 initiated 6 weeks following tumor engraftment blocked tumor growth in 12/12 treated mice, whereas all 5 untreated mice demonstrated disease progression. The results of these studies provide the framework for clinical trials to examine the therapeutic potential of the SGN-70 monoclonal antibody in WM.
Effects of Thermal, Moisture and Mechanical Loading Conditions on Interfacial Fracture Toughness using Brazil-nut Specimens (2006)

Interfacial delamination is a common failure mode in multi-layered IC packages. In this paper, an experimental technique using Brazil-nut specimens is employed to determine the interfacial fracture toughness of an adhesively sandwiched joint with introduction of edge interfacial crack. The interface studied here is the die attach material/copper leadframe interface. Tensile loads are applied to the specimens at various loading angles until the failure of the samples. Design of experiments (DOE) is applied to study variations in strain rates and thickness of the sandwich structure. In addition, the effects of moisture content and temperature on the interfacial adhesion are investigated. For the DOEs conducted, as the loading angle increases from 20/spl deg/ to 90/spl deg/, the interfacial fracture toughness decreases. It is found that moisture absorption and increase of temperature have detrimental effects on the die attach material and likewise results in a corresponding decrease in fracture toughness. Failure patterns of the delaminated surfaces were observed with the scanning electron microscope (SEM) to determine the cohesive/adhesive modes of failure. The fracture toughness and its corresponding mode mixity are determined from the measured critical load by finite element modeling computation.
A Solution to the Pavement Edge Drop Off Problem (2007)

Recent research has indicated that many Run-Off-Road (ROR) accidents are the result of pavement edge drop-offs. ROR accidents occur predominantly on two-lane, undivided rural roads. Many of these roads have minimal or no shoulders at the lane edge, resulting in sharp vertical drop-offs to the roadside. The situation is aggravated by overlay paving on existing roadways with no shoulder treatment. These conditions create a serious safety problem when vehicles traveling at highway speeds unintentionally leave the travel lane and enter the unimproved shoulder area. When drop-offs exceed 76 cm (3 in), vehicle recovery becomes difficult and frequently results in driver loss of control. The Federal Highway Administration (FHWA) has begun an effort to develop design specifications and evaluate hardware to eliminate this problem. Studies have shown that an angled edge of less than 45 degrees to the horizontal provides a ramp that allows vehicles to safely re-enter the roadway with little loss of control, even at speeds up to 88 kph (55 mph). The typical current practice is post paving manual construction to backfill and taper to the pavement edge, using soil or stone. This solution is subject to deterioration due to weathering action. Simple strike-off devices attached to the paver have also been tried to produce the desired wedge. Such devices produce poor surface finish and little or no compaction of the tapered surface, reducing durability. Recently, more sophisticated devices have been developed that produce more durable safety edges. This paper will document the results of comparative evaluation of the new technology by several states.
Correction to Exploration of Organic Acid Chain Length on Water-Soluble Silicon Quantum Dot Surfaces (2011)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Exploration of Organic Acid Chain Length on Water-Soluble Silicon Quantum Dot SurfacesRhett J. Clark, Michael K. M. Dang, and Jonathan G. C. Veinot*Cite this: Langmuir 2011, 27, 5, 2073Publication Date (Web):January 14, 2011Publication History Received29 September 2010Published online14 January 2011Published inissue 1 March 2011https://pubs.acs.org/doi/10.1021/la103911jhttps://doi.org/10.1021/la103911jcorrectionACS PublicationsCopyright © 2011 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views600Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (518 KB) Get e-AlertscloseSUBJECTS:Organic acids,Quantum dots,Silicon Get e-Alerts
VERTICAL WALL LOADS IN A MODEL GRAIN BIN WITH NON-AXIAL INTERNAL INSERTS (2004)

A study was conducted to estimate the degree of load asymmetry in a bin with non-axial internal inserts. Internalinserts in the form of an annulus segment were attached to the wall, and their influence on vertical wall loads during centricfilling and discharge in a model bin were measured. Wall and floor loads were measured in a corrugated-wall model grainbin with a diameter of 2.44 m and a height of 7.3 m filled with soft red winter wheat to a depth of 6.7 m (height-to-diameterratio of 2.75). Tests were conducted with inserts that extended circumferentially 30, 60, or 90 around the bin, having awidth of 7.6, 15, or 23 cm and attached to the bin wall at height-to-diameter (H/D) ratios of 0.31, 0.62, or 0.95. These insertsrepresented between 1% and 8.6% of the bin floor area. The results showed that with centric filling, considerable asymmetryof static wall loads occurred. The asymmetric loading was caused by the horizontal component of the velocity of the grainstream filling the bin, produced by the drag conveyor. This loading created wall moments in the bin of approximately 3 kN-m.The wall moments generated by imperfect centric filling varied depending on the angular position of the inserts. For a 23 cmwide, 90 insert, which was the worst observed situation, the wall moment was approximately 5 kN-m. The onset of symmetricdischarge resulted in an increase in vertical wall load and a decrease in the wall moment. A change in flow pattern from massflow to funnel flow, as well as the influence of the insert, was clearly shown by the change in wall moment with dischargetime.
Kernel selection for power market inference via block successive upper bound minimization (2014)

Advanced data analytics are undoubtedly needed to enable the envisioned smart grid functionalities. Towards that goal, modern statistical learning tools are developed for day-ahead electricity market inference. Congestion patterns are modeled as rank-one components in the matrix of spatio-temporal prices. The new kernel-based predictor is regularized by the square root of the nuclear norm of the sought matrix. Such a regularizer not only promotes low-rank solutions, but it also facilitates a systematic kernel selection methodology. The non-convex optimization problem involved is efficiently driven to a stationary point following a block successive upper bound minimization approach. Numerical tests on real high-dimensional market data corroborate the interpretative merits and the computational efficiency of the novel method.
Design Rules for Single-Mode and Polarization-Independent Silicon-on-Insulator Rib Waveguides Using Stress Engineering (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> There is a trend towards miniaturization of silicon photonic circuits due to superior performance and small cost. Design rules that must be imposed on the geometry of optical waveguides to make them behave as polarization-independent and single-mode devices are well known for waveguides with relatively large cross sections and for some small cross-sectional rib waveguides with vertical sidewalls and an air top cladding. The influence of the top oxide cover on waveguide birefringence was analyzed recently, but only for relatively large cross-sectional waveguides. This paper reports simulations for both single-mode and polarization-independent behavior for small cross-sectional waveguides with variable rib width, etch depth, top oxide cover thickness, and sidewall angle. The results show that the stress-induced effects must be taken into account to satisfy both requirements. Design rules to maintain birefringence-free operation and to satisfy single-mode behavior for small rib silicon-on-insulator (SOI) waveguides are presented. </para>
Classified displays of web search results. (2011)

Most text retrieval systems return a ranked list of results in response to a user's search request. Such lists can be long and overwhelming. Furthermore, results on different topics or different aspects of the same topic are intermixed in the list requiring users to sift through a long undifferentiated list to find items of interest. We have been exploring the use of automatic text classification techniques combined with novel interface ideas to allow users to quickly focus in on results of interest. Our approach combines the advantages of human knowledge in an initial classification stage with the broad coverage available with text retrieval systems. In a series of user studies we developed and evaluated several interfaces for structuring search results in order to better understand the cognitive processes that lead to effective analysis of search results. There are two key aspects to our work that we describe in more detail: 1) automatic text classification algorithms for quickly and accurately tagging ew content, and 2) novel interface to support structured search.
ChemInform Abstract: Synthesis of Highly Enantioenriched 3,4‐Dihydroquinolin‐2‐ones by 6‐Exo‐trig Radical Cyclizations of Axially Chiral α‐Halo‐ortho‐alkenyl Anilides. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks (2019)

Optical coherence tomography (OCT) enables the non-invasive acquisition of high-resolution three-dimensional cross-sectional images at micrometer scale and is mainly used in the field of ophthalmology for diagnosis as well as monitoring of eye diseases. Also in other areas, such as dermatology, OCT is already well established. Due to its non-invasive nature, OCT is also employed for research studies involving animal models. Manual evaluation of OCT images of animal models is a challenging task due to the lack of imaging standards and the varying anatomy among models. In this paper, we present a deep learning algorithm for the automatic segmentation of several layers of mouse skin in OCT image data using a deep convolutional neural network (CNN). The architecture of our CNN is based on the U-net and is modified by densely connected convolutions. We compared our adapted CNN with our previous algorithm, a combination of a random forest classification and a graph-based refinement, and a baseline U-net. The results showed that, on average, our proposed CNN outperformed our previous algorithm and the baseline U-net. In addition, a reduction of outliers could be observed through the use of densely connected convolutions.
Hierarchically aligned fibrous hydrogel films through microfluidic self‐assembly of graphene and polysaccharides (2018)

Despite significant interest in developing extracellular matrix (ECM)-inspired biomaterials to recreate native cell-instructive microenvironments, the major challenge in the biomaterial field is to recapitulate the complex structural and biophysical features of native ECM. These biophysical features include multiscale hierarchy, electrical conductivity, optimum wettability, and mechanical properties. These features are critical to the design of cell-instructive biomaterials for bioengineering applications such as skeletal muscle tissue engineering. In this study, we used a custom-designed film fabrication assembly, which consists of a microfluidic chamber to allow electrostatic charge-based self-assembly of oppositely charged polymer solutions forming a hydrogel fiber and eventually, a nanocomposite fibrous hydrogel film. The film recapitulates unidirectional hierarchical fibrous structure along with the conductive properties to guide initial alignment and myotube formation from cultured myoblasts. We combined high conductivity, and charge carrier mobility of graphene with biocompatibility of polysaccharides to develop graphene-polysaccharide nanocomposite fibrous hydrogel films. The incorporation of graphene in fibrous hydrogel films enhanced their wettability, electrical conductivity, tensile strength, and toughness without significantly altering their elastic properties (Young's modulus). In a proof-of-concept study, the mouse myoblast cells (C2C12) seeded on these nanocomposite fibrous hydrogel films showed improved spreading and enhanced myogenesis as evident by the formation of multinucleated myotubes, an early indicator of myogenesis. Overall, graphene-polysaccharide nanocomposite fibrous hydrogel films provide a potential biomaterial to promote skeletal muscle tissue regeneration.
Sulfated polysaccharides inhibit browning of apple juice and diced apples (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSulfated polysaccharides inhibit browning of apple juice and diced applesCindy B. S. Tong and Kevin B. HicksCite this: J. Agric. Food Chem. 1991, 39, 10, 1719–1722Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/jf00010a004https://doi.org/10.1021/jf00010a004research-articleACS PublicationsRequest reuse permissionsArticle Views274Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Simulation of phase equilibria for polymer–supercritical solvent mixtures (1998)

Phase equilibria for mixtures of a polymer and a supercritical solvent are investigated by means of expanded Gibbs ensemble simulations. Both lower and upper critical solution temperature (LCST and UCST) phenomena are observed for such systems. A closed-loop phase diagram is observed for systems with no specific interactions. The results of our simulations for Lennard-Jones polymer–solvent mixtures are in qualitative agreement with experimental data for polymers in supercritical solvents.
A Magnetic Gram Stain for Bacterial Detection (2012)

Magnetizing: Bacteria are often classified into gram-positive and gram-negative strains by staining with crystal violet (CV). The described bioorthogonal modification of CV with trans-cyclooctene (TCO) can be used to render gram-positive bacteria magnetic with tetrazine-functionalized magnetic nanoparticles (MNP-Tz). This method allows class-specific automated magnetic detection and magnetic separation.