gebhart/patrepeval huggingface dataset:
Abstract 1910: Infiltration of ovarian carcinoma by altered plasmacytoid dendritic cells could contribute to local immune tolerance (2010)

Abstract Ovarian carcinomas are usually considered as immunogenic tumors, as they are capable of inducing tumor-associated antigen immunity. However, immune system fails to eradicate established tumors partly due to alteration of immunosurveillance and induction of an active process of « tolerization » by the tumor microenvironment. We prospectively collected blood, tumors, and ascites samples from 38 patients with ovarian carcinomas (localized and advanced stages) and 35 healthy donors that gave written informed consent. Lin−CD4+CD11c−CD123+BDCA2+ pDC are the most abundant DC subset within ovarian carcinomas and neoplasic ascitis while they are profoundly depleted in peripheral blood of ovarian carcinoma patients compared to healthy donors. The depletion of pDC in patient's blood is partially restored when they are in complete remission (after chemotherapy and surgery). These observations suggest preferential pDC recruitment into tumor tissues that may involve CCR7 and CD62L which are downregulated in Tumor-associated (TA)-pDC compared to ascitis or blood pDC. Furthermore, TApDC express a partially mature phenotype compared to patient's blood and ascitis pDC that may reflect an in situ activation. Importantly, ex vivo TApDC produce lower amounts of IFN-α, TNF-α, IL-6 and RANTES in response to TLR ligands than ascitis or healthy donor pDC, suggesting a specific inhibition by ovarian tumor environment. In vitro, tumor or ascitis-derived surnageants (SNTUM) induce inhibition of the production of IFN-α and TNF-α by healthy pDC in response to TLR activation, suggesting the implication of soluble factors in this functional inhibition. In addition, TApDC but not ascitis pDC or healthy donors pDC direct allogeneic naive CD4+ T lymphocytes to produce high amounts of IL-10. Thus, TApDC may contribute to the tumor environmental immunosuppressive network. Elucidation of the mechanisms of dysfunctions of TApDC could have clinically relevant implications for future therapeutic strategies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1910.
UHF RFID Temperature Sensor Tag Integrated into a Textile Yarn (2022)

This paper presents the design of an ultra high-frequency (UHF) radio frequency identification (RFID) sensor tag integrated into a textile yarn and manufactured using the E-Thread<sup>®</sup> technology. The temperature detection concept is based on the modification of the impedance matching between RFID tag's antenna and the chip. This modification is created by the change in the resistance of a thermistor integrated within the tag system due to a temperature variation. Moreover, in order to obtain an environment independent detection, a differential approach is proposed that avoids the use of a pre-calibration phase by the use of a reference tag. Experimental characterization demonstrates the RFID sensor's potential of detecting a temperature variation or a temperature threshold between 25 and 70 °C through the variation of the transmitted differential activation power.
Biaryl polyamides as a new class of DNA quadruplex-binding ligands (2009)

We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.
Mesenchymal Stem Cells as Immunomodulator Therapies for Immune-Mediated Systemic Dermatoses (2011)

Mesenchymal stems cells (MSCs) are a population of multipotent cells residing in several readily available adult tissue compartments, thus allowing for their ex vivo expansion. To date, therapeutic applications of MSCs have focused on their ability to hone to and support the repair of damaged tissues. More recent evidence suggests that MSCs possess low immunogenicity and a diverse array of immunosuppressive properties. In thisarticle, we will review the basic biology of bone marrow-derived MSCs including their immunoregulatory effects and the putative mechanisms underlying them. We will then present some of the recent clinical applications of MSCs that have leveraged these effects for the treatment of immune-mediated dermatoses such as graft-versus-host disease and systemic lupus erythematosus. Although MSCs offer great therapeutic promise, we will also highlight a number of pertinent challenges that should be overcome before their successful clinical translation.
A New Biopolymer-Free, Low-Solids, High-Density Reservoir Drilling Fluid: Laboratory Development and Field Implementation (2004)

Summary Low-solids, brine-based reservoir drilling fluids (RDFs) are widely accepted as beneficial to optimizing compatibility with the completion design while minimizing fluid-related formation damage. Traditionally, the maximum density attainable with a low-solids fluid has been limited because of either the prohibitively high cost of the required base brine or the poor performance of viscosifying biopolymers in a dense, divalent cationic environment. An RDF has been developed that exhibits unusually high quality rheological behavior in high-density calcium- and zinc-based brines without the aid of a biopolymer. The new fluid shows a unique shear-thinning rheological profile that features a relatively low high-shear-rate viscosity along with a relatively high low-shear-rate viscosity (LSRV). This behavior is highly unusual in high-density, brine-based RDFs. A result of this behavior is that effective hole cleaning is provided without generating excessive high-shear-rate viscosities that lead to excessive equivalent circulating densities (ECDs). The first field trial of this fluid was on the reservoir section of Well 34/10 I-1-AH in the Gulfaks Satellites Development in the Norwegian sector of the North Sea. Fluid properties during pretesting, mixing, drilling, and completion of this section are detailed in this paper.
HER2-Overexpressing Breast Cancers Amplify FGFR Signaling upon Acquisition of Resistance to Dual Therapeutic Blockade of HER2 (2017)

<b>Purpose:</b> Dual blockade of HER2 with trastuzumab and lapatinib or pertuzumab has been shown to be superior to single-agent trastuzumab. However, a significant fraction of HER2-overexpressing (HER2<sup>+</sup>) breast cancers escape from these drug combinations. In this study, we sought to discover the mechanisms of acquired resistance to the combination of lapatinib + trastuzumab.<b>Experimental Design:</b> HER2<sup>+</sup> BT474 xenografts were treated with lapatinib + trastuzumab long-term until resistance developed. Potential mechanisms of acquired resistance were evaluated in lapatinib + trastuzumab-resistant (LTR) tumors by targeted capture next-generation sequencing. <i>In vitro</i> experiments were performed to corroborate these findings, and a novel drug combination was tested against LTR xenografts. Gene expression and copy-number analyses were performed to corroborate our findings in clinical samples.<b>Results:</b> LTR tumors exhibited an increase in <i>FGF3/4/19</i> copy number, together with an increase in FGFR phosphorylation, marked stromal changes in the tumor microenvironment, and reduced tumor uptake of lapatinib. Stimulation of BT474 cells with FGF4 promoted resistance to lapatinib + trastuzumab <i>in vitro</i> Treatment with FGFR tyrosine kinase inhibitors reversed these changes and overcame resistance to lapatinib + trastuzumab. High expression of <i>FGFR1</i> correlated with a statistically shorter progression-free survival in patients with HER2<sup>+</sup> early breast cancer treated with adjuvant trastuzumab. Finally, <i>FGFR1</i> and/or <i>FGF3</i> gene amplification correlated with a lower pathologic complete response in patients with HER2<sup>+</sup> early breast cancer treated with neoadjuvant anti-HER2 therapy.<b>Conclusions:</b> Amplification of FGFR signaling promotes resistance to HER2 inhibition, which can be diminished by the combination of HER2 and FGFR inhibitors. <i>Clin Cancer Res; 23(15); 4323-34. ©2017 AACR</i>.
Исследование эффективности потенциального лекарственного средства - ингамина(tm) на модели неинфекционного воспаления легких (2004)

The potential drug ingamine (glutarylhistamine) showed pronounced anti-inflammatory activity on a model of acute noninfectious pneumonia and in the stage of chronic inflammation induced by singe instillation of Sephadex (5 mg/kg) in Wistar rats. A 6-day treatment with ingamine (50 - 500 μg/kg) by inhalation, intragastric, and intraperitoneal administration produced an anti-inflammatory effect (expressed to various degrees), which was manifested by a decrease in alveolitis, bronchitis, obstructive emphysema, lymphocyte-neutrophile infiltration of interalveolar septa, cytosis, and neutrophile component of bronchoalveolar lavage and by normalization of the cytogram. The most pronounced effect was observed upon inhalation in a dose of 500 μg/kg. In the stage of chronic inflammation, the inhalation of ingamine in a dose of 500 μg/kg produced a significant antiinflammatory action for both 10- and 20-day treatment. The effect was comparable with that of the inhaled glucocorticoid budesonide.
Achieving sub-50 milliseconds recovery upon BGP peering link failures (2005)

We first show by measurements that BGP peering links fail as frequently as intradomain links and usually for short periods of time. We propose a new fast-reroute technique where routers are prepared to react quickly to interdomain link failures. For each of its interdomain links, each router precomputes a protection tunnel, i.e. an IP tunnel to an alternate nexthop which can reach the same destinations as via the protected link. We propose a BGP-based auto-discovery technique that allows each router to learn the candidate protection tunnels for its links. Each router selects the best protection tunnels for its links and when it detects an interdomain link failure, it immediately encapsulates the packets to send them through the protection tunnel. Our solution is applicable for the links between large transit ISPs and also for the links between multi-homed stub networks and their providers. Furthermore, we show that transient forwarding loops (and thus the corresponding packet losses) can be avoided during the routing convergence that follows the deactivation of a protection tunnel in BGP/MPLS VPNs and in IP networks using encapsulation.
Energy capture by a tetranuclear metal cluster complex. Synthesis and characterization of PtOs3(CO)10(.mu.-.eta.2-dppm)[Si(OMe)3](.mu.-H) and its metastable photoisomer (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnergy capture by a tetranuclear metal cluster complex. Synthesis and characterization of PtOs3(CO)10(.mu.-.eta.2-dppm)[Si(OMe)3](.mu.-H) and its metastable photoisomerRichard D. Adams, Jeffrey E. Cortopassi, Jeffrey Aust, and Michael MyrickCite this: J. Am. Chem. Soc. 1993, 115, 19, 8877–8878Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/ja00072a066https://doi.org/10.1021/ja00072a066research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature (2019)

Endothelial cells actively maintain an anti-thrombotic environment; loss of this protective function may lead to thrombosis and systemic coagulopathy. The transcription factor ERG is essential to maintain endothelial homeostasis. Here, we show that inducible endothelial ERG deletion (Erg<sup>iEC-KO</sup>) in mice is associated with spontaneous thrombosis, hemorrhages and systemic coagulopathy. We find that ERG drives transcription of the anticoagulant thrombomodulin (TM), as shown by reporter assays and chromatin immunoprecipitation. TM expression is regulated by shear stress (SS) via Krüppel-like factor 2 (KLF2). In vitro, ERG regulates TM expression under low SS conditions, by facilitating KLF2 binding to the TM promoter. However, ERG is dispensable for TM expression in high SS conditions. In Erg<sup>iEC-KO</sup> mice, TM expression is decreased in liver and lung microvasculature exposed to low SS but not in blood vessels exposed to high SS. Our study identifies an endogenous, vascular bed-specific anticoagulant pathway in microvasculature exposed to low SS.
Hydrophilic Submicron Nanogel Particles for Specific Recombinant Proteins Extraction and Purification (2020)

In biomedical diagnosis and bionanotechnologies, the extraction and purification of proteins and protein derivatives are of great interest. In fact, to purify recombinant proteins for instance, new methodologies and well appropriate material supports need to be established and also to be evaluated. In this work, hydrophilic nanohydrogel particles were prepared for recombinant proteins extraction for purification purpose. The prepared nanohydrogel polymer-based particles are hydrophilic below the volume phase transition temperature (TVPT) and dehydrated above the TVPT, due to the thermally sensitive poly(N-alkyl acrylamide) and poly(N-alkyl methacrylamide) derivatives. Then, the use of heavy metal ions in the presence of such functional particles should specifically capture recombinant proteins (i.e., proteins bearing a poly(histidine) part). In order to understand and to optimize the specific capture and the purification of recombinant proteins, various parameters have been investigated as a systematic study. Firstly, the adsorption was investigated as a function of pH and protein concentration. According to high hydration of the prepared nanohydrogel, no marked adsorption was observed. Secondly, the effect of pH was investigated and found to be the driven parameter affecting the metal ions immobilization and the recombinant proteins complexation. As a result, high protein complexation was observed at basic pH compared to non-complexation at acidic pH medium. The immobilized proteins via complexation were released by changing the pH. This decomplexation seems to be effective but depends on fixation conditions and particle surface structure.
Suppementary Figure 1 from Shifts in the Fecal Microbiota Associated with Adenomatous Polyps (2023)

&lt;p&gt;Supplementary Figure 1. Gut microbial composition and diversity in patients with and without adenomas. A) Microbial composition was similar between groups across all taxonomic levels. The groups did not differ in terms of α-diversity: B) observed number of operational taxonomic units (OTUs) or C) the Shannon diversity index. The groups did not cluster by β-diversity: D) unweighted and E) weighted UniFrac distance metrics.&lt;/p&gt;
Designing genetic algorithms for the state assignment problem (1995)

Finding the best state assignment for implementing a synchronous sequential circuit is important for reducing silicon area or chip count in many digital designs. This state assignment problem (SAP) belongs to a broader class of combinatorial optimization problems than the well studied traveling salesman problem, which can be formulated as a special case of SAP. The search for a good solution is considerably involved for the SAP due to a large number of equivalent solutions, and no effective heuristic has been found so far to cater to all types of circuits. In this paper, a matrix representation is used as the genotype for a genetic algorithm (GA) approach to this problem. A novel selection mechanism is introduced, and suitable genetic operators for crossover and mutation, are constructed. The properties of each of these elements of the GA are discussed and an analysis of parameters that influence the algorithm is given. A canonical form for a solution is defined to significantly reduce the search space and number of local minima. Experiments with several examples show that the GA approach yields results that are often comparable to, or better than those obtained using established heuristics that embody extensive domain knowledge.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Large Planar Holographic Reflectarray for Fresnel-Zone Microwave Wireless Power Transfer at 5.8 GHz (2018)

We present a 5.8 GHz Fresnel-zone microwave wireless power transfer experiment leveraging a large planar holographic metasurface reflectarray to form a focused spot at a distance of 6.5 m. The 1.5 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> holographic metasurface is fabricated from 15 panels having total dimensions of 122×127 cm, and is comprised of over 4,000 reflective patch resonators on the top surface of a 3.0 mm thick FR-4 substrate. A constrained hologram approach is used to discretize the desired hologram and approximate the desired focal spot given the Lorentzian coupled amplitude-phase response of the patch resonators. When the metasurface is illuminated by a 20 dB standard-gain horn 1.8 m away, it produces a spot with a 3 dB beam waist (FWHM) of approximately 50 cm. The experimentally measured beam profile matches the simulated beam profile to ± 1 dB within the beam, and we estimate almost 40% of the transmitted power was incident onto the receiver at the focus point.
Hemoglobin Encapsulation With Polyethylene Glycol-modified and Unmodified Vesicles: Systemic and Microvascular Hemodynamics at 80% Blood Substitution (1997)

Phospholipid vesicles containing purified hemoglobin (Hb vesicles, HbV) of high stability and uniform size have been developed to provide oxygen carrying capacity to plasma expanders. Their function as a blood replacement was tested in exchange transfusion where 80% of the red blood cell mass was substituted with suspensions of vesicles in 5% human serum albumin (HSA) solution. Vesicles were tested with membranes that were unmodified (HbV) or conjugated with polyethylene glycol (PEG-HbV). Both materials yielded normal systemic hemodynamic conditions at all levels of exchange which could not be achieved with HSA alone. Subcutaneous microvascular studies in awake hamsters showed that PEG-HbV yielded significantly improved microhemodynamic conditions relative to unmodified HbVs. The tissue oxygenation was lower than in the blood-perfused microcirculation. These results highlight the significance of microvascular analysis in the study and design of blood substitutes, while the development and availability of these vesicles provides a unique opportunity to determine the optimal set of parameters needed to design a blood substitute.
Analysis and Compensation of Nonidealities in Frequency Multiplier-Based High-Frequency Vector Signal Generators (2019)

This paper expounds on the application of frequency multipliers for the frequency upconversion of amplitude- and vector-modulated signals to high frequencies. First, a complex baseband equivalent Volterra series behavioral model is derived for representing the envelope transformation of frequency multipliers. Based on this model, a low-complexity baseband digital predistortion (DPD) scheme is developed to mitigate unwanted distortions exhibited by the frequency multipliers. The proposed DPD scheme consists of three modules: (1) a polynomial predistorter (PD) is first employed to mitigate the memoryless (ML) distortions associated with the frequency conversion; (2) a Dth order root module is included to correct for the phase modulation (PM)-PM distortions exhibited by the frequency multiplier with a frequency multiplication factor of D; and (3) a pruned Volterra-based PD is added to correct for residual distortions attributed to the output stage. As a proof of concept using a low-complexity experimental setup, the proposed DPD scheme is used to linearize several frequency multipliers, namely, a frequency doubler with an output at 12.5 GHz, a frequency quadrupler to produce an output at 25 GHz, and a frequency tripler with an output at 63 GHz. The proposed DPD scheme showed excellent capacity to linearize these frequency multipliers when driven by orthogonal frequency division multiplexing signals with modulation bandwidths up to 400 MHz with less than 56 coefficients.
(Invited) Sion Power (2016)

Sion Power Corporation has created Licerion ® , a comprehensive battery system that significantly enhances energy and cycle life of rechargeable batteries with metallic lithium anode. The core element of Sion Power’s Licerion ® technology is a physically protected metallic lithium anode. Physical protection is based on ceramic-polymer composite membranes and is combined with specialized cell design and electrolyte systems providing smooth, dendrite-free lithium deposition and chemical protection of exposed metallic lithium surface. This approach addresses safety and cycle life problems that have historically plagued lithium metal electrodes. Protected lithium anodes are currently combined with intercalated metal oxide cathodes typically used for Li-ion batteries ( Licerion ® - Ion) and with advanced sulfur cathodes ( Licerion ® - Sulfur). Sion Power Corporation in collaboration with BASF is working aggressively on realizing the impressive potential of the Licerion ® technology targeting 500 Wh/kg, 1000 Wh/L and 1000 cycles. This presentation will discuss: Failure mechanisms of rechargeable batteries with metallic lithium anode. Approaches pursued by Sion Power in collaboration with BASF towards next generation of Licerion ® - Sulfur and Licerion ® - Ion batteries targeting to meet and exceed requirements for EV application and for extended unmanned aerial vehicle (UAV) flights. Current status of 350 - 450 Wh/kg Licerion ® - Ion and Licerion ® - Sulfur batteries their cycle life and high power and extreme low temperature variations.