gebhart/patrepeval huggingface dataset:
Transfer of influenza vaccine–primed costimulated autologous T cells after stem cell transplantation for multiple myeloma leads to reconstitution of influenza immunity: results of a randomized clinical trial (2010)

Severe immune deficiency follows autologous stem cell transplantation for multiple myeloma and is associated with significant infectious morbidity. This study was designed to evaluate the utility of a pretransplantation vaccine and infusion of a primed autologous T-cell product in stimulating specific immunity to influenza. Twenty-one patients with multiple myeloma were enrolled from 2007 to 2009. Patients were randomly assigned to receive an influenza-primed autologous T-cell product or a nonspecifically primed autologous T-cell product. The study endpoint was the development of hemagglutination inhibition titers to the strain-specific serotypes in the influenza vaccine. Enzyme-linked immunospot assays were performed to confirm the development of influenza-specific B-cell and T-cell immunity. Patients who received the influenza-primed autologous T-cell product were significantly more likely to seroconvert in response to the influenza vaccine (P = .001). Seroconversion was accompanied by a significant B-cell response. No differences were observed in the global quantitative recovery of T-cell and B-cell subsets or in global T-cell and B-cell function. The provision of a primed autologous T-cell product significantly improved subsequent influenza vaccine responses. This trial was registered at www.clinicaltrials.gov as #NCT00499577.
Biometrically auditable public key infrastructure technology for secure multimedia content (2005)

A system for signing and tracing the use of digital content based on biometrically generated key-pairs is described. The system is designed to protect the fair use rights of end-users and can be readily incorporated into networked CE appliances.
Changing the future of additive manufacturing (2014)

Dr Florian Bechmann, head of development at Concept Laser, reports on trends and increased quality requirements in 3D printing.
Covalent functionalization of carbon nanohorns with porphyrins: Nanohybrid formation and photoinduced electron and energy transfer (2007)

International audience
Real-Time Parameter Identification and Integration on Deadbeat-Direct Torque and Flux Control (DB-DTFC) Without Inducing Additional Torque Ripple (2016)

This paper is dedicated to exploring real-time parameter identification approaches and their integration with deadbeat-direct torque and flux control (DB-DTFC) without additional torque ripple. Using the voltage model at medium- and high-speed ranges, DB-DTFC is insensitive to parameters. Performance degrades at low speeds with the rotor time constant errors, because the current model is utilized for flux linkage estimation. Two different real-time parameter estimation approaches are developed, including a flux observer-based model reference adaptive system (MRAS) and a pulsating flux injection-based method. Both are experimentally evaluated for how well they mitigate DB-DTFC performance degradation at low speed. For the MRAS-based method, the fundamental components are used for parameter convergence, which does not induce additional torque ripple. For the injection-based method, traditional d-axis pulsating voltage vector injection used in indirect field-oriented control (IFOC) yields significant torque ripple, particularly at high speed. The proposed pulsating flux injection scheme used in DB-DTFC excites the same magnitude of current harmonics and induces no additional torque ripple over a wide speed range.
Improved fourier-transform ion-cyclotron-resonance mass spectrometry of large biomolecules (1993)

Initial results from a Fourier-transform mass spectrometer with a 6.2 Tesla magnet using electrospray ionization show substantial improvements in resolution, mass accuracy, mass range, signal/noise, and tandem mass spectromehy capabilities compared to our earlier 2.8 T instrument that demonstrated the first unit resolution mass spectra of molecules as large as myoglobin (17 kDa). The new instrument exhibits greater than 10(6) and 10(5) resolving power for 8.6 and 29 kDa, respectively, proteins. Using an internal standard, the mass measuring error for myoglobin is less than 1 ppm. Nozzle-skimmer dissociation during electrospray of carbonic anhydrase (29 kDa) has yielded 38 fragment ions for which both mass and charge are identifiable; of these, 21 have been assigned to expected oligopeptide fragments.
Three-dimensional orientation from texture using Gabor wavelets (1991)

We present a method for measuring the three-dimensional orientation of planar surfaces. We derive a model relating the spatially varying instantaneous frequency of the image texture to the instantaneous frequency of the surface texture, to the orientation of the surface, and to the parameters of the imaging system. We measure the localized frequency at each image point with Gabor wavelets and use it to solve for the surface orientation according to the model. The method does not require the extraction of discrete texture elements. The algorithm has a mean error of about 5 degrees in the measured slant and tilt on a test set of 12 real-world surfaces.
Tannic Acid-Dependent Modulation of Selected Lactobacillus plantarum Traits Linked to Gastrointestinal Survival (2013)

Probiotic L. plantarum WCFS1 is able to overcome the toxic effects of tannic acid. This dietary constituent modulates molecular traits linked to the adaptation to intestinal environment in ways previously shown to enhance GI-survival.
Synthesis of (+)-tetrahydropseudodistomin (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of (+)-tetrahydropseudodistominSpencer Knapp and Jeffrey J. HaleCite this: J. Org. Chem. 1993, 58, 10, 2650–2651Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/jo00062a003https://doi.org/10.1021/jo00062a003research-articleACS PublicationsRequest reuse permissionsArticle Views225Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Radiomic Phenotypes for Improving Early Prediction of Survival in Stage III Non-Small Cell Lung Cancer Adenocarcinoma after Chemoradiation (2022)

We evaluate radiomic phenotypes derived from CT scans as early predictors of overall survival (OS) after chemoradiation in stage III primary lung adenocarcinoma. We retrospectively analyzed 110 thoracic CT scans acquired between April 2012-October 2018. Patients received a median radiation dose of 66.6 Gy at 1.8 Gy/fraction delivered with proton (55.5%) and photon (44.5%) beam treatment, as well as concurrent chemotherapy (89%) with carboplatin-based (55.5%) and cisplatin-based (36.4%) doublets. A total of 56 death events were recorded. Using manual tumor segmentations, 107 radiomic features were extracted. Feature harmonization using ComBat was performed to mitigate image heterogeneity due to the presence or lack of intravenous contrast material and variability in CT scanner vendors. A binary radiomic phenotype to predict OS was derived through the unsupervised hierarchical clustering of the first principal components explaining 85% of the variance of the radiomic features. C-scores and likelihood ratio tests (LRT) were used to compare the performance of a baseline Cox model based on ECOG status and age, with a model integrating the radiomic phenotype with such clinical predictors. The model integrating the radiomic phenotype (C-score = 0.69, 95% CI = (0.62, 0.77)) significantly improved (p<0.005) upon the baseline model (C-score = 0.65, CI = (0.57, 0.73)). Our results suggest that harmonized radiomic phenotypes can significantly improve OS prediction in stage III NSCLC after chemoradiation.
Relationship Between Attachment Loss and Precipitating Serum Antibody to Actinobacillus actinomycetemcomitans in Adolescents and Young Adults Having Severe Periodontal Destruction, (1982)

The purpose of this study was to determine if adolescents and young adults with severe periodontal disease had precipitating serum antibody reactive with Actinobacillus actinomycetemcomitans, and, if so, to correlate presence or absence of the precipitin with clinical patterns of periodontal destruction. Double diffusion in gel was used to detect precipitins. Test and known positive standard sera were run in different wells against a common well containing a minute of sonicates from two strains of A. actinomycetemcomitans (Y4 and N27). Periodontal loss of attachment was measured with a probe on four surfaces per tooth; missing and unerupted teeth were noted with the aid of radiographs. Precipitating antibody was seen in 77% of sera from 22 subjects with localized juvenile periodontitis, 40% of 35 young subjects with more generalized severe disease, and 2% of 44 periodontally healthy individuals. About 80% of the positive reactions were with strain Y4. Within the diseased groups, there were significantly fewer involved teeth in subjects with precipitating antibody (Ab+) than among those in whose sera precipitins were not seen (Ab-). Comparisons of the distribution and severity of involved teeth between Ab+ and Ab- subjects were consistent with an hypothesis that high levels of antibody specific for A. actinomycetemcomitans have a protective effect against periodontal destruction.
Local activation of TGF-beta1 at endometriosis sites. (2007)

These results suggest that TGF-beta1 activity is increased at sites of endometriosis due to enhanced production of both uPA and TGF-beta1 by glandular epithelium and because plasmin activates TGF-beta1 after being converted from plasminogen by uPA.
Public’s preferences for health science popularization short videos in China: a discrete choice experiment (2023)

Participants favor free health popularization short videos, which are hospital accounts, with content that is illustrated, understandable, meets their needs, and can serve as a warning. In the future, the production of health popularization short videos should focus on improving the diversity and relevance of video content, making it as easy to understand to achieve good science popularization effects.
Nucleation mechanism of metal-vapor atoms on photochromic diarylethene surface with a low glass transition temperature (2018)

Metal pattern formation on organic surfaces is essential in organic electronics. Selective metal-vapor deposition using photochromic diarylethene (DAE) is a promising method to prepare fine metal patterns by maskless evaporation. Metal-vapor atoms are adsorbed, diffused, and then desorbed from the colorless surface with a low glass transition temperature. We, however, found that metal deposition started at a specific time (deposition-threshold time, tth) even on the colorless surface by continuous evaporation. tth was investigated using a quartz crystal microbalance. We elucidated that metal-nucleation sites were generated by chemical reactions between metal atoms and surface DAE molecules. The number of nucleation sites increases during metal evaporation and when the sites are located in the diffusion range of surface metal atoms, metal-atom nucleation for film-formation starts. This is the origin of tth. This result would provide important knowledge for the preparation of electrodes for organic devices based on selective metal-vapor deposition.
Colour constancy with error bars (1999)

The colours in images are confounded by the colour of the illuminant: a yellow light leads to colours that are more yellow than they ought to be. Colour constancy algorithms attempt to estimate and correct for the colour of the illuminant. Unfortunately existing colour constancy algorithms do not work very well. The reason for their failure is easy to understand: different collections of reflectances viewed under different lights can induce exactly the same image. It follows that inverting the image formation process, thereby extracting the illuminant, is an ill-posed problem. To circumvent the ill-posedness of the problem authors have sought solutions for certain special cases, e.g. when there is a white reflectance in a scene. Unfortunately these special case scenarios often do not hold in practice; blindly assuming that they do hold also leads to poor colour constancy. In this paper we work with the ill-posedness inherent in the problem. In particular, rather than trying to solve for a unique answer we instead compute the set of all plausible answers. This set is characterised by the set median and associated error bars. For example, our algorithm might estimate that the illuminant colour is white (the median answer) but that it could be a little reddish or bluish (the error bars). We have found that the magnitude of the error bars correlates with the colour diversity in a scene. The more colours there are, the less ill-posed is the recovery problem and so the smaller the error bars. It is proposed that error bars provide useful information for any computer vision module that uses colour (e.g. face trackers).
27.2: High Definition 458 ppi OLED with Logic Circuit using Low Temperature Single‐Crystal‐Silicon (LTSS) TFT Backplane Driven by 2.5 V Single Power Supply (2012)

Abstract We succeeded in formation of single crystal silicon (Low Temperature Single‐Crystal Silicon: LTSS) over non‐alkali glass. In our prototyped high definition 458 ppi AMOLED display using this LTSS as a backplane, low power consumption of drivers (about 1.7 mW) with 2.5 V single power supply voltage is achieved.
Adjunct Proceedings of the 28th Annual ACM Symposium on User Interface Software & Technology (2015)

We are very excited to welcome you to the 28th Annual ACM Symposium on User Interface Software and Technology (UIST), held from November 8-11th 2015, in Charlotte, North Carolina, USA.

UIST is the premier forum for the presentation of research innovations in the software and technology of human-computer interfaces. Sponsored by ACM's special interest groups on computer-human interaction (SIGCHI) and computer graphics (SIGGRAPH), UIST brings together researchers and practitioners from diverse areas including graphical & web user interfaces, tangible & ubiquitous computing, virtual & augmented reality, multimedia, new input & output devices, fabrication, wearable computing and CSCW.

UIST 2015 received 297 technical paper submissions. After a thorough review process, the 39-member program committee accepted 70 papers (23.6%). Each anonymous submission that entered the full review process was first reviewed by three external reviewers, and a meta-review was provided by a program committee member. If, after these four reviews, the submission was deemed to pass a rebuttal threshold, we asked the authors to submit a short rebuttal addressing the reviewers' concerns. A second member of the program committee was then asked to examine the paper, rebuttal, and reviews, and to provide their own meta-review. The program committee met in person in Berkeley, California, USA on June 25th and 26th, 2015, to select which papers to invite for the program. Submissions were accepted only after the authors provided a final revision addressing the committee's comments.

In addition to papers, our program includes two papers from the ACM Transactions on Computer-Human Interaction journal (TOCHI), as well as 22 posters, 45 demonstrations, and 8 student presentations in the eleventh annual Doctoral Symposium. Our program also features the seventh annual Student Innovation Contest. Teams from all over the world will compete in this year's contest, which focuses on blurring the lines between art and engineering and creating tools for robotic storytelling. UIST 2015 will feature two keynote presentations. The opening keynote will be given by Ramesh Raskar (MIT Media Lab) on extreme computational imaging. Blaise Aguera Y Arcas from Google will deliver the closing keynote on machine intelligence.

We welcome you to Charlotte, a city full of southern hospitality. We hope that you will find the technical program interesting and thought-provoking. We also hope that UIST 2015 will provide you with enjoyable opportunities to engage with fellow researchers from both industry and academia, from institutions around the world.
TANSLOCATIONS INVOLVING CD28 ARE RARE IN PERIPHERAL T‐CELL LYMPHOMAS (2017)

Introduction: Peripheral T-cell lymphoma (PTCL) represents a group of aggressive neoplasms of mature T cells with heterogeneous molecular background. Recently, different gene rearrangements fusing CD28 to CTLA4 or ICOS(CTLA4(ex3)_CD28(ex4); CTLA4(ex1)_CD28(ex2); CTLA4(ex2)_CD28(ex4); and ICOS(ex1)_CD28(ex2)) were discovered by RNA sequencing analysis in AITL (angioimmunoblastic T-cell lymphoma), CTCL (cutaneous T-cell lymphoma), or ATLL (adult T-cell leukaemia/lymphoma). While available RNAseq data suggest that these gene fusions are overall rare (2.5%-5% of PTCLs), a high frequency of CTLA4(ex3)_CD28(ex4) fusion was found (38%) in a large series of AITL, PTCL-NOS, and ENKTCL (extranodal natural killer/T-cell lymphoma) FFPE samples screened by RT-PCR (Haematologica, June 2016; 101(6)). Here, we screened by RT-PCR the above described CD28 fusions in 257 frozen diagnostic tumor samples (104 AITL, 25 T-follicular helper-derived [TFH] PTCL, 59 PTCL-NOS, 26 CTCL, 14 ENKTCL, 11 EATL [enteropathy associated T-cell lymphoma], 9 ALK-negative ALCL [anaplastic large cell lymphoma], 6 ATLL, and 3 HSTL [hepatosplenic T-cell lymphoma]) from the Tenomic biobank. Methods: 500 ng of trizol-extracted and quality-controlled mRNA (bioanalyser) was reverse-transcribed using SuperScript III enzyme and random hexamers. CD28 fusions and beta-actin (internal control, 198 bp) PCR products were analyzed by agarose gel electrophoresis. Three fusions were cloned into expression vector and transduced into HEK293T cells to generate positive controls. All positive samples and a subset of negative samples were cross-validated in 2 different laboratories. Results: CD28 fusions were detected in 13/257 (5%) cases (8 TFH-derived PTCL, 3 PTCL-NOS, 1 ATLL, and 1 CTCL). Three of these cases harbored 2 different translocations. The most common rearrangement was ICOS(ex1)_CD28(ex2) (11/16 fusions), followed by CTLA4(ex3)_CD28(ex4) (3/16 fusions) while the other two CTLA4 translocations were identified in one patient each. Thus, the prevalence of CTLA4(ex3)_CD28(ex4) fusion (found in one case each of TFH-derived PTCL, PTCL-NOS and CTCL) was 1.2%. CD28 fusions were found in 8/129 (6.2%) AITL and other TFH-derived PTCLs. All the positive cases harbored ICOS(ex1)_CD28(ex2) rearrangement and one case with a dual rearrangement had an additional CTLA4(ex3)_CD28(ex4) fusion. In a subset of 85 TFH-derived PTCL also explored by targeted deep sequencing analysis, CD28 fusions in 4 patients were mutually exclusive to CD28 mutations. Overall, CD28 alterations in 12/85 (14%) of these patients did not impact OS or PFS. Keywords: peripheral T-cell lymphomas (PTCL)
Performance analysis of hybrid ALOHA/CDMA anti-collision scheme for RFID systems over fading channels (2015)

This paper proposes and theoretically investigates the efficiency of a hybrid ALOHA/CDMA anti-collision scheme for passive radio frequency identification (RFID) systems. The decorrelating detector is supposed to be used at RFID reader, while each tag is assumed to assign with a Gold code and responds to the reader in a randomly selected time slot. The tag identification is performed considering the influence of both code collisions and detection errors due to fading channels. The system efficiency, which is defined as the average number of successfully detected tags over a slot, is theoretically derived. Computer simulations are also performed to validate the theoretical analysis. In the numerical results, we evaluate the performance of the tag identification procedure with system parameters that maximize the system efficiency. We also confirm the superiority of the proposed system in comparison with conventional ALOHA-based ones.
Dark-field scanning in situ spectroscopy platform for broadband imaging of resected tissue (2011)

A dark-field geometry spectral imaging system is presented to raster scan thick tissue samples in situ in 1.5 cm square sections, recovering full spectra from each 100 μm diameter pixel. This spot size provides adequate resolution for wide field scanning, while also facilitating scatter imaging without requiring sophisticated light-tissue transport modeling. The system is demonstrated showing accurate estimation of localized scatter parameters and the potential to recover absorption-based contrast from broadband reflectance data measured from 480 nm up to 750 nm in tissue phantoms. Results obtained from xenograft pancreas tumors show the ability to quantitatively image changes in localized scatter response in this fast-imaging geometry. The polychromatic raster scan design allows the rapid scanning necessary for use in surgical/clinical applications where timely decisions are required about tissue pathology.
GSM Receiverin90-nm CMOS (2006)

A newdiscrete-time receiver architecture enables to specifically circumvent CMOS integration issues, taking advantage ofZIFarchitectures yetescaping impactofflicker noise andsecond-order front-end non-linearity. Thisarchitecture, compatible withfurther scaling, wasimplemented fora GSM receiver in90-nmCMOS.Thisreceiver occupies 1-mm2corearea, achieves -108-dBm sensitivity, and-16-dBm IIP3. Itisbasedona discrete-time approach centering thebaseband signal athalfthe sampling frequency. Thereceiver integrates Low-Noise Amplifier, filters andtwo40-MHzsigmadelta Analog toDigital Converters achieving a12-bit resolution in100kHz.
A Parametric Study on Laser Welding of Magnesium Alloy AZ31 by a Fiber Laser (2014)

Laser welding of wrought magnesium alloy has been investigated through experimentation and simulation. Laser butt welds and laser lap welds were performed on 2.0 mm thick magnesium alloy AZ31 plates using a 1 kW fiber laser and shielded with argon gas. The effects of laser power and welding speed on weld geometry and microstructure were investigated. Tensile tests were performed to verify weld quality. Through experimentation, a novel processing map was created, which gives the ranges of operating parameters of laser power and welding speed that resulted in viable, defect-free welds. Numerical simulations were performed to predict the weld pool geometry and keyhole stability, and resultant microstructures are shown to be in good agreement with experimental results.