gebhart/patrepeval huggingface dataset:
Diversity and sex differences in rectal gland volatiles of Queensland fruit fly, Bactrocera tryoni (Diptera: Tephritidae) (2022)

Rectal gland volatiles are key mediators of sexual interactions in tephritid fruit flies. We used solid-phase microextraction (SPME) plus gas chromatography-mass spectrometry (GC-MS) and gas chromatography-flame ionization detection (GC-FID) to substantially expand rectal gland chemical characterisation of the Queensland fruit fly (Bactrocera tryoni (Diptera: Tephritidae); Qfly). The SPME GC-MS analysis identified 24 of the 30 compounds previously recorded from Qfly rectal glands, plus another 21 compounds that had not previously been reported. A few amides and fatty acid esters dominated the chromatograms of males and females respectively, but we also found other esters, alcohols and aldehydes and a ketone. The GC-FID analyses also revealed over 150 others, as yet unidentified, volatiles, generally in lesser amounts. The GC-FID analyses also showed 49 and 12 compounds were male- and female-specific, respectively, both in single sex (virgin) and mixed sex (mostly mated) groups. Another ten compounds were male-specific among virgins but undetected in mixed sex groups, and 29 were undetected in virgins but male-specific in mixed sex groups. The corresponding figures for females were four and zero, respectively. Most short retention time peaks (including a ketone and an ester) were male-specific, whereas most female-biased peaks (including five fatty acid esters) had long retention times. Our results indicate previously unsuspected diversity of rectal gland volatiles that might have pheromone functions in males, but far fewer in females.
Polymer nanostructure materials for space defense applications (2013)

The unique functional characteristics of nanostructured material are stemming mainly from a large surface-to-volume-ratio and on quantum effects; can yield numerous potential space defense applications. The objective of this study is to explore the polarimetric characterization of polymer nanomaterials, using Mueller matrix and Stokes parameters analysis. Specifically, gold nanoparticles were dispersed within a matrix of two-different polymer domains and their polarimetric response to infrared light was studied.
PET/CT-Diagnostik beim Bronchialkarzinom (2014)

Das Bronchialkarzinom ist bei Männern weltweit die häufigste maligne Erkrankung und in Deutschland die häufigste Krebstodesursache. Trotz Fortschritte in der Diagnostik und der Behandlung des Bronchialkarzinoms ist die Überlebenswahrscheinlichkeit der betroffenen Pa­tienten weiterhin überwiegend nicht günstig. Entscheidend für die Überlebenswahrscheinlichkeit ist eine frühzeitige Diagnosestellung und eine genaue Bestimmung des Tumorstadiums zur Festlegung der weiteren Therapie. Hierzu wird neben konventionellen Untersuchungsverfahren wie der CT immer häufiger mit der PET oder PET/CT ein funktionelles nuklearmedizinisches Verfahren eingesetzt, das die Darstellung des Zuckerstoffwechsels mithilfe des Glukoseanalogons <sup>18</sup>F-2’-Fluor-2’-deoxy-D-glukose (FDG) in vivo ermöglicht. Verschiedene Studien konnten eine signifikant höhere diagnostische Genauigkeit für die FDG-PET/CT im Vergleich zu anderen diagnostischen Methoden wie der CT zeigen. Daher empfiehlt die aktuelle S3-Leitlinie zur Diagnostik, Therapie und Nachsorge des Lungenkarzinoms die Durchführung der PET/CT zur Abklärung und Beurteilung der Dignität von unklaren pulmonalen Rundherden, zur Bestimmung des Tumorstadiums einschließlich des Lymphknoten-Stagings und der Entdeckung von Fernmetastasen und bei einem begründeten Verdacht auf ein Rezidiv eines Bronchialkarzinoms. Ein weiteres wichtiges Einsatzgebiet für die PET/CT, das derzeit Gegenstand intensiver Forschung ist, stellt die frühzeitige Beurteilung des Therapieansprechens beim Bronchialkarzinom dar. Aktuelle Studien konnten beobachten, dass mithilfe der PET/CT frühzeitig während der Therapie eine Beurteilung des Therapieansprechens und damit eine Vorhersage zur Überlebenswahrscheinlichkeit möglich zu sein scheint.
Feasibility of High-Resolution Electrical Mapping for Characterizing Conduction Blocks Created by Gastric Ablation (2019)

The interstitial cells of Cajal (ICC) initiate, coordinate and propagate bioelectrical slow wave activity that drives gastric motility. In the healthy human stomach, slow wave activity is highly organized. Gastric motility disorders are associated with dysrhythmias. While ablation is widely used to treat cardiac dysrhythmias, this approach has yet to be trialed in the stomach. In this study, radiofrequency (RF) ablation was applied in pig stomachs in vivo to create targeted electrical conduction blocks. Ablations were performed at temperature control mode (55-70°C), and resultant conduction blocks were identified and verified using high-resolution electrical mapping. Termination of slow wave propagation at ablation sites was confirmed by a decrease in extracellular slow wave amplitude from 1.7 ± 0.2 mV to an undetectable amplitude, as well as spatiotemporal pattern analysis of conduction blocks. The use of high-resolution electrical mapping can now be employed to investigate ablation as a potential therapy for gastric dysrhythmias in motility disorders.
Development of an Extreme High Temperature n-Type Ohmic Contact to Silicon Carbide (2012)

We report on the initial demonstration of a tungsten-nickel (75:25 at. %) ohmic contact to silicon carbide (SiC) that performed for up to fifteen hours of heat treatment in argon at 1000 °C. The transfer length method (TLM) test structure was used to evaluate the contacts. Samples showed consistent ohmic behavior with specific contact resistance values averaging 5 x 10-4 Ω-cm 2 . The development of this contact metallization should allow silicon carbide devices to operate more reliably at the present maximum operating temperature of 600 °C while potentially extending operations to 1000 °C.
Understanding Scattering of Sound at Basin-scales with Numerical Experiments and Theory (1997)

Abstract : There are two goals of this research. The first is to understand the role of internal waves and the mesoscale in scattering sound in the vertical dimension. The second is to develop computer algorithms to predict the extent of this scattering.
Characterization and immobilization of engineered sialidases from <em>Trypanosoma rangeli</em> for transsialylation (2017)

A sialidase (EC 3.2.1.18; GH 33) from non-pathogenic Trypanosoma rangeli has been engineered with the aim of improving its transsialylation activity. Recently, two engineered variants containing 15 and 16 amino acid substitutions, respectively, were found to exhibit significantly improved transsialylation activity: both had a 14 times higher ratio between transsialylation and hydrolysis products compared to the first reported mutant TrSA5mut. In the current work, these two variants, Tr15 and Tr16, were characterized in terms of pH optimum, thermal stability, effect of acceptor-to-donor ratio, and acceptor specificity for transsialylation using casein glycomacropeptide (CGMP) as sialyl donor and lactose or other human milk oligosaccharide core structures as acceptors. Both sialidase variants exhibited pH optima around pH 4.8. Thermal stability of each enzyme was comparable to that of previously developed T. rangeli sialidase variants and higher than that of the native transsialidase from T. cruzi (TcTS). As for other engineered T. rangeli sialidase variants and TcTS, the acceptor specificity was broad: lactose, galactooligosaccharides (GOS), xylooligosaccharides (XOS), and human milk oligosaccharide structures lacto-N-tetraose (LNT), lacto-N-fucopentaose (LNFP V), and lacto-N-neofucopentaose V (LNnFP V) were all sialylated by Tr15 and Tr16. An increase in acceptor-to-donor ratio from 2 to 10 had a positive effect on transsialylation. Both enzymes showed high preference for formation α(2,3)-linkages at the non-reducing end of lactose in the transsialylation. Tr15 was the most efficient enzyme in terms of transsialylation reaction rates and yield of 3’-sialyllactose. Finally, Tr15 was immobilized covalently on glyoxyl-functionalized silica, leading to a 1.5-fold increase in biocatalytic productivity (mg 3’-sialyllactose per mg enzyme) compared to free enzyme after 6 cycles of reuse. The use of glyoxyl-functionalized silica proved to be markedly better for immobilization than silica functionalized with (3-aminopropyl)triethoxysilane (APTES) and glutaraldehyde, which resulted in a biocatalytic productivity which was less than half of that obtained with free enzyme.
Stabilized Plasmid–Lipid Particles: Pharmacokinetics and Plasmid Delivery to Distal Tumors following Intravenous Injection (2000)

A previous study has shown that plasmid DNA can be encapsulated in lipid particles (SPLP, "stabilized plasmid lipid particles") of approximately 70 nm diameter composed of 1,2-dioleoyl-3-phosphatidyl-ethanolamine (DOPE), the cationic lipid N,N-dioleoyl-N,N-dimethylammonium chloride (DODAC) and poly(ethylene glycol) conjugated to ceramide (PEG-Cer) using a detergent dialysis process (Wheeler et al. (1999) Gene Therapy 6, 271-281). In this work we evaluated the potential of these SPLPs as systemic gene therapy vectors, determining their pharmacokinetics and the biodistribution of the plasmid and lipid components. It is shown that the blood clearance and the biodistribution of the SPLPs can be modulated by varying the acyl chain length of the ceramide group used as lipid anchor for the PEG polymer. Circulation lifetimes observed for SPLPs with PEG-CerC14 and PEG-CerC20 were t(1/2) = approximately 1 and approximately 10 h, respectively. The SPLPs are stable while circulating in the blood and the encapsulated DNA is fully protected from degradation by serum nucleases. The accelerated clearance of SPLPs with PEG-CerC14 is accompanied by increased accumulation in liver and spleen as compared to PEG-CerC20 SPLPs. Delivery of intact plasmid to liver and spleen was detected. Significant accumulation (approximately 10% of injected dose) of the long circulating SPLPs with PEG-CerC20 in a distal tumor (Lewis lung tumor in the mouse flank) was observed following i.v. application and delivery of intact plasmid to tumor tissue at approximately 6% injected dose/g tissue is demonstrated.
Key Aspects on Development of High Efficiency Heterojunction and IBC-Heterojunction Solar Cells: Towards 22% Efficiency on Industrial Size (2012)

In this paper, we show the latest results of CEA-INES on the development of HET and IBC-HET solar cells. We have focused the research on the optimization of the amorphous (a-Si:H) and TCO layers to increase Jsc and FF values on HET cells. Moreover, we have fabricated silver –free HET solar cells with a Copper electroplating metallization. We also show our latest results obtained with a new structure combining HET and IBC (Interdigitated Back Contact) concepts: the SLASH IBC cell (Structuring by Laser Ablation of Silicon Heterojunction). Short-circuit current issues for both standard - and IBC – HET solar cells are discussed in this paper. Efficiencies higher than 22% have been achieved on 100 cm2 standard HET solar cells and close to 20% on 25 cm2 SLASH IBC cells.
Raising: Dutch Between English and German (2011)

As a complement to C. B. van Haeringen's classic comparative study (1956) that positioned the grammar of Dutch in between the grammars of English and German, this study compares the productivity of three kinds of “raising” patterns in these languages: Object-to-Subject, Subject-to-Object, and Subject-to-Subject raising. It establishes the extent to which Dutch, as well as English and German, have evolved from the old West Germanic starting point these languages are assumed to have shared in this area of grammar. The results are a test case for Hawkins' (1986) case syncretism account of the difference in “explicit-ness” between the grammars of English and German. *
Development of a Linker-Mediated Immunoassay Using Chemically Transitioned Nanosensors (2020)

Sensitive and specific quantification of protein biomarkers is important in medical diagnostics, academic research, and pharmaceutical development. However, multiple binding steps in conventional sandwich immunoassay protocols result in high assay hands-on-time and delayed results. This is particularly relevant for medical diagnostics, where assay turn-around-time can have an immense impact on patient outcomes. To address this limitation, we report the assembly of nanosensors prepared using DNA-antibody conjugates, which combine capture and detection antibody binding steps by facilitating rapid antigen capture. Following antigen binding, detection antibodies are released using chemically induced complex rearrangement. A panel of 12 chemical additives are characterized to identify melting point depressants capable of rapidly denaturing double stranded DNA (dsDNA) linkers, and 8 compounds are demonstrated to be capable of disrupting dsDNA while maintaining the integrity of protein binding. This technique is then validated for the measurement of the heart attack indicator cardiac troponin I and is shown to successfully combine antigen binding steps while also increasing detection sensitivity 42×. Linker-mediated immunoassays are also demonstrated to provide robust quantification in human serum and are shown to be compatible with each of the most commonly used immunoassay detection modalities.
High Spatial-Resolution and Sensitivity Interferometric OTDR (2005)

Many kinds of silica-based glass waveguide circuits1 and LiNbO3 waveguides devices2 have been proposed. These devices are highly potential for optical communication systems and optical sensor systems. To develop these waveguide devices, a diagnosing system for detecting fault locations and characterizing them is necessary. The interferometric optical-time-domain reflectometer (OTDR) is promising to apply to diagnosing the optical devices, because of high spatial- resolution and high sensitivity compared with conventional OTDR systems. The interferometric OTDR was based on the Michelson interferometer using a low-coherent light source3. The reflectance profile inside the optical components is described by the distribution of the interferometric signal power between the reflection light from the scattering centers and the reference light.
Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent (2020)

Novel imidazole-based TGFβR1 inhibitors were identified and optimized for potency, selectivity, and pharmacokinetic and physicochemical characteristics. Herein, we report the discovery, optimization, and evaluation of a potent, selective, and orally bioavailable TGFβR1 inhibitor, <b>10</b> (BMS-986260). This compound demonstrated functional activity in multiple TGFβ-dependent cellular assays, excellent kinome selectivity, favorable pharmacokinetic properties, and curative <i>in vivo</i> efficacy in combination with anti-PD-1 antibody in murine colorectal cancer (CRC) models. Since daily dosing of TGFβR1 inhibitors is known to cause class-based cardiovascular (CV) toxicities in preclinical species, a dosing holiday schedule in the anti-PD-1 combination efficacy studies was explored. An intermittent dosing regimen of 3 days on and 4 days off allowed mitigation of CV toxicities in one month dog and rat toxicology studies and also provided similar efficacy as once daily dosing.
THE SIGNIFICANCE OF SIMULTANEOUS TRANSURETHRAL RESECTION OF BLADDER TUMOR AND PROSTATE IN SUPERFICIAL BLADDER TUMOR PATIENTS WITH BLADDER OUTLET OBSTRUCTION (2008)

You have accessJournal of Urology1 Apr 2008THE SIGNIFICANCE OF SIMULTANEOUS TRANSURETHRAL RESECTION OF BLADDER TUMOR AND PROSTATE IN SUPERFICIAL BLADDER TUMOR PATIENTS WITH BLADDER OUTLET OBSTRUCTION Young Deuk Choi, Won Sik Ham, Kyochul Koo, Young Hoon Lee, Hyun Jin Chung, and Seung Ruyl Lee Young Deuk ChoiYoung Deuk Choi More articles by this author , Won Sik HamWon Sik Ham More articles by this author , Kyochul KooKyochul Koo More articles by this author , Young Hoon LeeYoung Hoon Lee More articles by this author , Hyun Jin ChungHyun Jin Chung More articles by this author , and Seung Ruyl LeeSeung Ruyl Lee More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60857-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "THE SIGNIFICANCE OF SIMULTANEOUS TRANSURETHRAL RESECTION OF BLADDER TUMOR AND PROSTATE IN SUPERFICIAL BLADDER TUMOR PATIENTS WITH BLADDER OUTLET OBSTRUCTION." The Journal of Urology, 179(4S), p. 294 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 294 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetrics Author Information Young Deuk Choi More articles by this author Won Sik Ham More articles by this author Kyochul Koo More articles by this author Young Hoon Lee More articles by this author Hyun Jin Chung More articles by this author Seung Ruyl Lee More articles by this author Expand All Advertisement PDF downloadLoading ...
SDR waveform components implementation on single FPGA multiprocessor platform (2010)

Multiprocessors in embedded systems have a bright future with Software Defined Radio (SDR) applications where both, high performance and high adaptability are required. Framed within this statement, this paper implements the two most important SDR waveform components: FFT and Viterbi Decoding, on our designed 16 Processing Element (PE) Network on chip (NoC) based general purpose Multiprocessors System on chip (MPSoC), implemented on a single chip Xilinx Virtex-4 FPGA. We designed a parallelization strategy, by synchronizing the PEs, for each of the two algorithms and obtained a speed-up of 6 with eight PEs, for radix-2 FFT and 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">16</sup> states of Viterbi Decoding. We also propose partitioning mechanism for SDR resources for PEs more than eight. The case study of our partitioning mechanism reduced execution time to 63%, thus an efficient answer to ITRS prediction.
Mechanism of action of 5-aminolevulinic acid dehydratese: stepwise order of addition of the two molecules of 5-aminolevulinic acid in the enzymic synthesis of porphobilinogen (1980)

Incorporation of [5-14C]-5-aminolevulinic acid into porphobilinogen in single-turnover enzymic experiments with mammalian 5-aminoleuvlinic acid dehydratase has revealed that of the two molecules of 5-aminolevulinic acid which are utilised for the formation of porphobilinogen it is the one contributing to the propionic acid side [atoms 1, 2, 3, 6, 7, and 8 in (2)] which is initially bound to the enzyme.
Technology and applications of distributed optical fibre sensors (1998)

The paper reviews the principles of operation, design and application of distributed fibre optic sensors. Examples are drawn primarily from the widely-used Raman-based distributed temperatures but other technologies and applications in civil engineering are also considered. (A) For the covering abstract see ITRD E127016.
Surface marker characteristics and Epstein-Barr virus studies of two established North American Burkitt's lymphoma cell lines. (1976)

Tumor cell lines have been established in continuous culture from two North American Burkitt's lymphomas. The SU-AmB-1 line, derived from a patient with low serum antibody titers to Epstein-Barr virus (EBV), was devoid of EBV genomes by the reaction for EBV-associated nuclear antigen (EBNA), could not be induced to express EBV antigens, and was highly refractory to EBV superinfection. Conversely, the SU-AmB-2 cell line, derived from a patient with "African type" serology, yielded a positive EBNA reaction and was readily inducible and superinfectable. Although both cell lines possessed B (bone-marrow-derived) cell characteristics, they had different surface marker patterns. It is postulated that two different classes of undifferentiated B cell lymphomas exist, one of which is positive for the presence of EBV genomes and occurs endemically in Africa and New Guinea and sporadically in other parts of the world, the other of which is EBV-negative and occurs sporadically throughout the world, including the endemic areas.
Glucose Detection With a Commercial MOSFET Using a ZnO Nanowires Extended Gate (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> ZnO nanowires were grown on Ag wire with a diameter of <formula formulatype="inline"><tex Notation="TeX">${\sim}\hbox{250}\ \mu$ </tex></formula>m and used in an electrochemical sensor. The enzyme glucose oxidase (GOD) was immobilized on the ZnO nanowires, and the Ag wire was connected directly to the gate of a MOSFET. Upon exposure to glucose (1– <formula formulatype="inline"><tex Notation="TeX">$\hbox{100}\ \mu$</tex></formula>M), the electrochemical response from the GOD induced a stable measurable voltage change on the gate leading to a strong modulation of the current through the MOSFET. For a sensor with uniform ZnO nanowires functionalized with GOD, a fast response time of less than 100 ms was demonstrated. The effect of the uniformity of the ZnO nanowires on the sensing property was also investigated. The extended-gate arrangement facilitated glucose detection in small sample volumes, and made it possible to demonstrate the present sensor concept using a standard low-threshold MOSFET. The extended-gate MOSFET sensor approach demonstrates the possibility and potential of the use of nanostructures coupled to standard electronic components for biosensing applications. </para>
Soluble OX40L and JAG1 Induce Selective Proliferation of Functional Regulatory T-Cells Independent of canonical TCR signaling (2017)

Regulatory T-cells (Tregs) play a pivotal role in maintaining peripheral tolerance. Increasing Treg numbers/functions has been shown to ameliorate autoimmune diseases. However, common Treg expansion approaches use T-Cell Receptor (TCR)-mediated stimulation which also causes proliferation of effector T-cells (Teff). To overcome this limitation, purified patient-specific Tregs are expanded ex vivo and transfused. Although promising, this approach is not suitable for routine clinical use. Therefore, an alternative approach to selectively expand functional Tregs in vivo is highly desired. We report a novel TCR-independent strategy for the selective proliferation of Foxp3+Tregs (without Teff proliferation), by co-culturing CD4+ T-cells with OX40 L+Jagged(JAG)-1+ bone marrow-derived DCs differentiated with GM-CSF or treating them with soluble OX40 L and JAG1 in the presence of exogenous IL-2. Tregs expanded using soluble OX40 L and JAG1 were of suppressive phenotype and delayed the onset of diabetes in NOD mice. Ligation of OX40 L and JAG1 with their cognate-receptors OX40 and Notch3, preferentially expressed on Tregs but not on Teff cells, was required for selective Treg proliferation. Soluble OX40L-JAG1-induced NF-κB activation as well as IL-2-induced STAT5 activation were essential for the proliferation of Tregs with sustained Foxp3 expression. Altogether, these findings demonstrate the utility of soluble OX40 L and JAG1 to induce TCR-independent Treg proliferation.
Analysis of Line Rush Current in Short Commutation for SHAPF (2007)

The current-source nonlinear load is normally composed of the thyristor or diode rectifier, but the process of the short commutation will cause the line rush current for the SHAPF. In order to solve this problem, a rush current inductor and rectifier, and a series-in SHAPF are proposed to suppress the line rush current in the paper. The simulation and experiment results verify their validity.