gebhart/patrepeval huggingface dataset:
Drp1 overexpression induces desmin disassembling and drives kinesin-1 activation promoting mitochondrial trafficking in skeletal muscle (2020)

Mitochondria change distribution across cells following a variety of pathophysiological stimuli. The mechanisms presiding over this redistribution are yet undefined. In a murine model overexpressing Drp1 specifically in skeletal muscle, we find marked mitochondria repositioning in muscle fibres and we demonstrate that Drp1 is involved in this process. Drp1 binds KLC1 and enhances microtubule-dependent transport of mitochondria. Drp1-KLC1 coupling triggers the displacement of KIF5B from kinesin-1 complex increasing its binding to microtubule tracks and mitochondrial transport. High levels of Drp1 exacerbate this mechanism leading to the repositioning of mitochondria closer to nuclei. The reduction of Drp1 levels decreases kinesin-1 activation and induces the partial recovery of mitochondrial distribution. Drp1 overexpression is also associated with higher cyclin-dependent kinase-1 (Cdk-1) activation that promotes the persistent phosphorylation of desmin at Ser-31 and its disassembling. Fission inhibition has a positive effect on desmin Ser-31 phosphorylation, regardless of Cdk-1 activation, suggesting that induction of both fission and Cdk-1 are required for desmin collapse. This altered desmin architecture impairs mechanotransduction and compromises mitochondrial network stability priming mitochondria transport through microtubule-dependent trafficking with a mechanism that involves the Drp1-dependent regulation of kinesin-1 complex.
GW24-e1814 The treatment result and secure appraisal of direct PCI in old patients with acute myocardial infarction complicated by cardiogenic shock (2013)

Objectives To investigate the effects and security of emergency percutaneous coronary intervention (PCI) in elderly patients with acute myocardial infraction (AMl) complicated by cardiogenic shock (CS). Methods 24 patients with AMI complicated by CS were treated by PCI in their 23 target lesions from 24 infarct related arteries (IRA). The mean age of patients was (69.2 ± 5.8) years. Before intervention the mean stenosis of IRA was 98.7% ± 0.6% and the blood flow was TIMI grade 0 in 19 patients and TIMI grade 1–2 in 5 patients, respectively. 23 stents were successfully implanted on 24 target lesions, but one implantation of stent failed of success. Results The rate of successful treatment for IRA and target lesions was 95.8%. The TIMI grade 3 blood flow achieved in 87.5%. The average opening time of IRA was (32.3 ± 6.8) min. 6 patients died after the operation and the total mortality was 25% in hospital. During the period of 12-months follow-up, there was not any attack of angina pectoris in 18 patients. 16 examples (88.9%) could be competent in the daily life. They had the higher quality of life. Conclusions Emergency percutaneous coronary intervention has significant effects and higher security in elderly high-risk patients with AMI complicated by CS.
Grain size monitoring of 3D flash memory channel poly-Si using multiwavelength Raman spectroscopy (2014)

Raman spectroscopy was used for characterizing poly-Si after thermal annealing of chemical vapor deposited (CVD) thin a-Si films in the vertical channel region of 3D V-NAND device wafers using various annealing conditions and techniques. Raman spectra, indicating crystallization of a-Si films and grain growth of poly-Si with respect to annealing conditions and techniques, was measured using a multiwavelength Raman spectroscopy system.
Memristor based computation-in-memory architecture for data-intensive applications (2015)

One of the most critical challenges for today's and future data-intensive and big-data problems is data storage and analysis. This paper first highlights some challenges of the new born Big Data paradigm and shows that the increase of the data size has already surpassed the capabilities of today's computation architectures suffering from the limited bandwidth, programmability overhead, energy inefficiency, and limited scalability. Thereafter, the paper introduces a new memristor-based architecture for data-intensive applications. The potential of such an architecture in solving data-intensive problems is illustrated by showing its capability to increase the computation efficiency, solving the communication bottleneck, reducing the leakage currents, etc. Finally, the paper discusses why memristor technology is very suitable for the realization of such an architecture; using memristors to implement dual functions (storage and logic) is illustrated.
Finite-Sample Analysis of Contractive Stochastic Approximation Using Smooth Convex Envelopes (2020)

Stochastic Approximation (SA) is a popular approach for solving fixed-point equations where the information is corrupted by noise. In this paper, we consider an SA involving a contraction mapping with respect to an arbitrary norm, and show its finite-sample error bounds while using different stepsizes. The idea is to construct a smooth Lyapunov function using the generalized Moreau envelope, and show that the iterates of SA have negative drift with respect to that Lyapunov function. Our result is applicable in Reinforcement Learning (RL). In particular, we use it to establish the first-known convergence rate of the V-trace algorithm for off-policy TD-learning. Importantly, our construction results in only a logarithmic dependence of the convergence bound on the size of the state-space.
Referee acknowledgment for 2013 (2014)

DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone.
The FinXX trial: Safety results in 600 patients (pts) randomized to either docetaxel (T) followed by cyclophosphamide (C) + epirubicin (E) + 5-FU (F) (CEF) or T + capecitabine (X) followed by CEX as adjuvant therapy for early breast cancer (BC) (2007)

11035 Background: Adding X to T extends survival in pts with metastatic BC. The primary objective of the FinXX trial is to compare recurrence-free survival with XT→CEX vs T→CEF as adjuvant therapy in pts with early stage BC. Secondary objectives were comparison of safety and overall survival. Methods: Between Jan 2004 and May 2005, 600 of a planned 1,500 pts were randomized to receive T x 3 → CEF x 3 (T 80 mg/m 2 d1 → C 600 mg/m 2 d1, E 75 mg/m 2 d1, F 600 mg/m 2 d1) or TX x 3 → CEX x 3 (T 60 mg/m 2 d1 + X 900 mg/m 2 bid d1–15 → C 600 mg/m 2 d1, E 75 mg/m 2 d1, X 900 mg/m 2 bid d1–15) q3 wks. Results: Grade 3/4 toxicities (CTCAE, v3) in &gt;5% of pts are shown below. 62 pts required G-CSF. Nos. of cycles with G-CSF were: T 34; XT 15; CEF 17; CEX 15. Adverse events (AEs) led to interruption of T in 7 pts (2%) and XT in 50 pts (16%). Median dose intensities at cycle 3 were T: 95%; XT: 84/97%; CEF: 98/97/98%; CEX: 98/98/84%. T dose reductions of =20% in cycle 3 were needed in 18% and 8% of pts receiving T and XT, respectively. 4 pts died during treatment: pulmonary embolism (n=1) with T and suicide, sudden death and colitis/sepsis (each n=1) with XT. Conclusions: XT→CEX is generally well tolerated. Treatment interruptions were more common with XT→CEX, but were effective in reducing development of grade 3/4 AEs. Neutropenic infections were less frequent with XT vs T and infrequent with XT, CEF and CEX. Rates of grade 3/4 diarrhea and HFS were acceptable with XT and minimal with CEX. Accrual is nearly complete; efficacy data are expected in 2009. [Table: see text] [Table: see text]
Innentitelbild: Breakable Hybrid Organosilica Nanocapsules for Protein Delivery (Angew. Chem. 10/2016) (2016)

In einer zerbrechlichen Schale eingeschlossene Proteine können in Zellen transportiert und anschließend freigesetzt werden. L. De Cola, E. A. Prasetyanto et al. beschreiben in ihrer Zuschrift auf S. 3384 ff. eine solche Schale, die aus disulfidverbrückten Siliciumdioxideinheiten aufgebaut ist. Nach Überführung der eingeschlossenen Proteine in die Zelle werden die Disulfidgruppen durch Reduktion gespalten, die Schalen reißen auf und die aktiven Proteine werden freigesetzt.
The Safety and Liveness Properties of a Protocol Family for Versatile Survivable Storage Infrastructures (CMU-PDL-03-105) (2018)

Survivable storage systems mask faults. A protocol family shifts the decision of which types of faults from implementation time to data-item creation time. If desired, each data-item can be protected from different types and numbers of faults with changes only to client-side logic. This paper presents proofs of the safety and liveness properties for a family of storage access protocols that exploit data versioning to efficiently provide consistency for erasure-coded data. Members of the protocol family may assume either a synchronous or asynchronous model, can tolerate hybrid crash-recovery and Byzantine failures of storage-nodes, may tolerate either crash or Byzantine clients, and may or may not allow clients to perform repair. Additional protocol family members for synchronous systems under omission and fail-stop failure models of storage-nodes are developed.
Direct metal writing: Controlling the rheology through microstructure (2017)

Most metal additive manufacturing approaches are based on powder-bed melting techniques such as laser selective melting or electron beam melting, which often yield uncontrolled microstructures with defects (e.g., pores or microcracks) and residual stresses. Here, we introduce a proof-of-concept prototype of a 3D metal freeform fabrication process by direct writing of metallic alloys in the semi-solid regime. This process is achieved through controlling the particular microstructure and the rheological behavior of semi-solid alloy slurries, which demonstrate a well suited viscosity and a shear thinning property to retain the shape upon printing. The ability to control the microstructure through this method yields a flexible manufacturing route to fabricating 3D metal parts with full density and complex geometries.
Improvement in performance of transparent organic light-emitting diodes with increasing sputtering power in the deposition of indium tin oxide cathode (2005)

The performance of transparent organic light-emitting diodes (OLEDs) can be substantially improved by increasing the rf sputtering power in the deposition of an indium tin oxide cathode. This dependence of device performance on sputtering power is quite different from that reported for transparent OLEDs. The effect is attributed to sputtering induced substrate-heating resulting in chemical reactions at the Al–LiF–Alq3 interface and electron injection enhancement. By effectively dissipating the energy of sputtered particles, device damage can be taken away. The findings herein show that a transparent OLED having better electron injection properties than a conventional OLED can be fabricated.
Evaluación prospectiva in vivo del ritmo de degradación de dispositivo de cierre en angioplastia coronaria (AngioSeal (2009)

Introduccion: Los dispositivos de cierre arterial estan disponibles de manera comercial como metodo para obtener una hemostasis arterial posterior a una intervencion percutanea coronaria. Sin embargo, poco se sabe de la compatibilidad in vivo y patrones de reabsorcion de estos dispositivos. En este estudio se tiene como objetivo caracterizar la absorcion in vivo del dispositivo de cierre vascular AngioSeal® con imagenes de ultrasonido intravascular (IVUS) seriadas e histologia. Metodos: Se obtuvo acceso femoral bajo fluoroscopia usando una tecnica percutanea tipica (Seldinger) y un cateter de 6F en 11 arterias femorales en 6 cerdos. Justo despues del retiro del cateter, un total de 11 dispositivos de cierre arterial AngioSeal fueron implantados. Usando un acceso carotideo, angiografia y ultrasonido intravascular fueron utilizados en diferentes puntos del estudio (Base, 3, 5, 7, 14, 30 y 42 dias). Las arterias fueron extraidas y procesadas para evaluacion histologica para la determinacion de la absorcion del dispositivo a 14 dias (3 dispositivos), 30 dias (4 dispositivos), y 42 dias (4 dispositivos). Resultados: El area maxima del componente intravascular en una seccion transversal permanecio estable hasta 14 dias por ultrasonido (18.7 ± 2.5 mm2) y disminuyo un 50% a 30 dias (9.46 ± 2.8 mm2) y hasta 78% para 42 dias (4.2 ± 2.9 mm2). Por histologia, hay una disminucion progresiva en el area del componente intravascular que comienza a partir del dia 14 (area = 19.7 ± 3.3 mm2) y continua disminuyendo para el dia 30 (14 ± 2.6 mm2) y dia 42 (4.6 ± 3.6 mm2). La evaluacion histologica demostro una absorcion casi completa del componente intravascular y sin signos de inflamacion residual para 42 dias. Conclusion: Imaginologia seriada usando ultrasonido intravascular demostro una absorcion casi completa del componente intravascular AngioSeal® para 42 dias en arterias femorales de cerdos normales. Al mismo tiempo, no existe evidencia de inflamacion residual vascular demostrada por histologia.
Development of a High-Performance Liquid Chromatography Assay for Bacillus thuringiensis var. san diego δ-Endotoxin (1990)

A Reverse Phase HPLC assay has been developed for quantifying the delta-endotoxin produced by Bacillus thuringiensis var. san diego. The effects of ethyleneglycol as a mobile phase modifier and in stabilizing solubilized delta-endotoxin are discussed.
A new microporous 12-ring zincosilicate THK-2 with many terminal silanols characterized by automated electron diffraction tomography (2020)

A newly synthesized microporous zincosilicate THK-2 (estimated structural composition: |(H<sub>2</sub>O)<sub>6.7</sub>(C<sub>6</sub>H<sub>13</sub>N)<sub>0.9</sub>|[Li<sub>0.5</sub>Zn<sub>3.1</sub>Si<sub>32</sub>O<sub>62.7</sub>(OH)<sub>9.3</sub>]) was characterized by single-crystal electron diffraction using the automated electron diffraction tomography (ADT) approach in combination with powder X-ray diffraction. The lattice constants and space group of as-synthesized THK-2 were a = 2.50377(7) nm, b = 1.43866(4) nm, c = 0.505369(8) nm, and Pccn (no. 56) with orthorhombic symmetry. Because the crystal lattice was almost identical to a hexagonal lattice (), the first several peaks in its powder X-ray diffraction data severely overlapped, which suppressed the structural information to decide the framework topology. In order to overcome this intrinsic difficulty, the structure model of THK-2 was initially obtained by the direct method based on ADT data and refined by the Rietveld method. Its 3-dimensional framework structure was elucidated and it consisted of 4-, 5-, 6-rings of tetrahedral Si and Zn atoms and a one-dimensional straight channel with a 12-ring pore opening. Zn atoms were incorporated into the framework as four-coordinated [ZnO<sub>4</sub>], although their distribution was confirmed to be disorderly. In the as-synthesized THK-2, the site occupancy of Zn was as low as 0.39; that is, more than 60% of the Zn sites were vacant. Hexamethyleneimine and water molecules were accommodated in the straight channel in a disordered manner. The material was stable upon calcination, and the BET specific surface area and micropore volume of calcined THK-2 were 240.6 m<sup>2</sup> g<sup>-1</sup> and 0.12 ml g<sup>-1</sup>, respectively.
Applications of Co-Rotating Twin-Screw Extruders (2020)

No AccessCo-Rotating Twin-Screw Extruders: ApplicationsNov 2020Applications of Co-Rotating Twin-Screw ExtrudersKlemens KohlgrüberKlemens Kohlgrüberhttps://doi.org/10.3139/9781569907825.004SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2020Pages: 217-339Print ISBN: 978-1-56990-781-8eISBN: 978-1-56990-782-5 Copyright & Permissions© 2021 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Optimization of norbornyl‐based carbocyclic nucleoside analogs as cyclin‐dependent kinase 2 inhibitors (2020)

We report on the discovery of norbornyl moiety as a novel structural motif for cyclin-dependent kinase 2 (CDK2) inhibitors which was identified by screening a carbocyclic nucleoside analogue library. Three micromolar hits were expanded by the use of medicinal chemistry methods into a series of 16 novel compounds. They had prevailingly micromolar activities against CDK2 and the best compound of the series attained IC<sub>50</sub> of 190 nM. The binding modes were explored in molecular details by modeling and docking. Quantum mechanics-based scoring was used to rationalize the affinities. In conclusion, the discovered 9-hydroxymethylnorbornyl moiety was shown by joint experimental-theoretical efforts to be able to serve as a novel substituent for CDK2 inhibitors. This finding opens door to the exploration of chemical space towards more effective derivatives targeting this important class of protein kinases.
Total synthesis of ionophore antibiotic X-14547A. 1. Enantioselective synthesis of the tetrahydropyran and tetrahydroindan building blocks (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of ionophore antibiotic X-14547A. 1. Enantioselective synthesis of the tetrahydropyran and tetrahydroindan building blocksK. C. Nicolaou, D. P. Papahatjis, D. A. Claremon, and R. E. Dolle IIICite this: J. Am. Chem. Soc. 1981, 103, 23, 6967–6969Publication Date (Print):November 1, 1981Publication History Published online1 May 2002Published inissue 1 November 1981https://pubs.acs.org/doi/10.1021/ja00413a036https://doi.org/10.1021/ja00413a036research-articleACS PublicationsRequest reuse permissionsArticle Views831Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Near-Field Interactions between Metal Nanoparticle Surface Plasmons and Molecular Excitons in Thin-Films. Part II: Emission (2012)

We systematically study the effect of near-field plasmon–exciton interactions between metal nanoparticles (NPs) and molecular thin-films. In part I, we discussed the effect of these interactions on the absorption of the organic molecules, whereas in this part, we probe their impact on the emission of the organic molecules by time-resolved and time-averaged photoluminescence measurements. Through carefully designed experiments, we are able to exclusively probe the effect of the presence of metal NPs on the emission of organic molecules while eliminating their influence on molecular excitation. For this study, we utilize Ag NPs in a size regime where absorption dominates light scattering, as well as several organic materials that emit at different wavelengths throughout the ultraviolet–visible–near-infrared spectrum. By introducing a transparent, nonemissive spacer layer, we are able to accurately probe the range of plasmon–exciton interactions. We find a good qualitative agreement between the photoluminescence measurements and calculations based on an analytical model. In general, we observe a strong reduction of the emission quantum yield in the presence of the Ag NPs within a distance of <30 nm. However, for poor emitters in combination with embedding media with a high permittivity, we find an emission enhancement due to the Ag NPs. Finally, we compare the results obtained from both parts of this study to discuss the potential application of near-field plasmon–exciton interactions in thin-film opto-electronic devices and sensors.
Dose Comparison Study of Allogeneic Mesenchymal Stem Cells in Patients With Ischemic Cardiomyopathy (The TRIDENT Study) (2017)

URL: http://www.clinicaltrials.gov. Unique identifier: NCT02013674.
A LATERALLY-IMPLANTED PIEZORESISTIVE SKIN-FRICTION SENSOR (2008)

This paper presents the packaging, fabrication, and calibration of a piezoresistive skin-friction sensor for the direct measurement of wall shear stress. The floating-element structure integrates laterally-implanted piezoresistors into the tether sidewalls to form a fully active Wheatstone bridge for electromechanical transduction. Experimental characterization at a bias voltage of 1.5 V indicates a sensitivity of 4.24 / V Pa , a noise floor of 11.4 / mPa Hz at 1 kHz , a linear response up to the maximum testing range of 2 Pa , and a flat dynamic response up to the testing limit of 6.7 kHz .
Flat output beam profile from an unstable resonator with a VRM of arbitrary central reflectivity (2001)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. Makki and J. Leger, "Flat output beam profile from an unstable resonator with a VRM of arbitrary central reflectivity," in Advanced Solid State Lasers, M. Fejer, H. Injeyan, and U. Keller, eds., Vol. 26 of OSA Trends in Optics and Photonics (Optica Publishing Group, 1999), paper ME1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Pressure-and Temperature-Dependent Terahertz Time-Domain Spectroscopy of Hydroquinone and its Clathrates (2019)

We study the low-energy dynamics of hydroquinone and its clathrates under pressure using terahertz time-domain spectroscopy. Transitions between different phases are observed. The absorption peaks are assigned to lattice vibrational modes using quantum-mechanical simulations. © 2019 The Author(s)
Comparison of Surface Functionalization of PLGA Composite to Immobilize Extracellular Vesicles (2021)

Endothelialization by materials provides a promising approach for the rapid re-endothelialization of a cardiovascular implantation. Although previous studies have focused on improving endothelialization through the immobilization of bioactive molecules onto the surface of biodegradable implants, comparative studies of effective surface modification have not yet been reported. Here, we conducted a comparative study on the surface modification of poly(lactide-co-glycolide) (PLGA)-based composites to graft mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) using three different materials, fibronectin (FN), polyethylenimine (PEI), and polydopamine (PDA), which have different bond strengths of ligand-receptor interaction, ionic bond, and covalent bond, respectively. Further in vitro analysis exhibited that MSC-EVs released from all modified films sustainably, but the MSC-EVs grafted onto the surface coated with PEI are more effective than other groups in increasing angiogenesis and reducing the inflammatory responses in endothelial cells. Therefore, the overall results demonstrated that PEI is a desirable coating reagent for the immobilization of MSC-EVs on the surface of biodegradable implants.
Theoretical and experimental investigation of the nonlinear dynamics of nanobubbles excited at clinically relevant ultrasound frequencies and pressures: The role of lipid shell buckling (2017)

Microbubbles (MBs) excited by ultrasound (Us) are used as contrast agents for the detection of blood vessels. MBs can also be used to enhance drug delivery. However, the usage of MBs is limited to the blood pool due to their large size; where detection of biomarkers on tumor cells and effective drug delivery, requires MBs to reach the tumor tissue outside of the vasculature.