gebhart/patrepeval huggingface dataset:
Modified Zero Time Delay Input Shaping for Industrial Robot With Flexibility (2017)

Although input shaping is an effective approach for vibration suppression in a variety of applications, the time delay introduced is not desired. Current techniques to reduce the time delay can not guarantee zero delay or may cause non-smooth motion, which is harmful for the actuators. In order to address such issue, a modified zero time delay input shaping is proposed in this paper. Experimental results show the advantage of the proposed approach.
α-Lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome (2007)

In animal experiments, the potent antioxidant and free radical scavenger alpha-lipoic acid has been shown to cause weight loss, ameliorate insulin resistance and atherogenic dyslipidemia, as well as to lower blood pressure, all of these being components of the metabolic syndrome. Recent investigations on its mechanisms of action indicate that alpha-lipoic acid can affect central and peripheral modulation of 5'-AMP-activated protein kinase, activate PPAR-alpha and PPAR-gamma, modulate PPAR-regulated genes and upregulate the expression of PPAR-gamma mRNA and protein in cardiac tissue and aorta smooth muscle. To a large extent, these findings can explain the observed beneficial metabolic effects of alpha-lipoic acid, supporting its potential application as a therapeutic agent for the treatment of the metabolic syndrome.
Postantibiotic effect of purified melittin from honeybee (Apis mellifera) venom againstEscherichia coliandStaphylococcus aureus (2009)

Since the ancient times, the antibacterial application of honeybee venom (BV) has been practised and persisted. We investigated the antibacterial activity of whole BV and purified melittin against Escherichia coli and Staphylococcus aureus by the minimum inhibitory concentrations (MICs) and the postantibiotic effects (PAEs). The in vitro PAEs of whole BV and isolated melittin were determined using E. coli and S. aureus. The PAEs of whole BV against E. coli and S. aureus were 0.15 h (1 x MIC), 2.4 h (5 x MIC), and 3.45 h (1 x MIC), respectively. The PAEs of melittin against E. coli and S. aureus were 0.1 h (1 x MIC), 3.2 h (5 x MIC), and 4.35 h (1 x MIC), respectively. These results suggest that whole BV and melittin will be developed as a novel antibacterial drug.
SCG10 is a JNK target in the axonal degeneration pathway (2012)

Axons actively self-destruct following genetic, mechanical, metabolic, and toxic insults, but the mechanism of axonal degeneration is poorly understood. The JNK pathway promotes axonal degeneration shortly after axonal injury, hours before irreversible axon fragmentation ensues. Inhibition of JNK activity during this period delays axonal degeneration, but critical JNK substrates that facilitate axon degeneration are unknown. Here we show that superior cervical ganglion 10 (SCG10), an axonal JNK substrate, is lost rapidly from mouse dorsal root ganglion axons following axotomy. SCG10 loss precedes axon fragmentation and occurs selectively in the axon segments distal to transection that are destined to degenerate. Rapid SCG10 loss after injury requires JNK activity. The JNK phosphorylation sites on SCG10 are required for its rapid degradation, suggesting that direct JNK phosphorylation targets SCG10 for degradation. We present a mechanism for the selective loss of SCG10 distal to the injury site. In healthy axons, SCG10 undergoes rapid JNK-dependent degradation and is replenished by fast axonal transport. Injury blocks axonal transport and the delivery of SCG10, leading to the selective loss of the labile SCG10 distal to the injury site. SCG10 loss is functionally important: Knocking down SCG10 accelerates axon fragmentation, whereas experimentally maintaining SCG10 after injury promotes mitochondrial movement and delays axonal degeneration. Taken together, these data support the model that SCG10 is an axonal-maintenance factor whose loss is permissive for execution of the injury-induced axonal degeneration program.
Comparative Genomic Hybridization Analysis of Adrenocortical Tumors of Childhood1 (1999)

Although several genes have been investigated in adrenal tumorigenesis, the genetic background of adrenocortical tumors (ACT) remains poorly characterized. In southern Brazil, the annual incidence of ACT is unusually high, ranging from 3.4-4.2/million children, compared with a worldwide incidence of 0.3/million children younger than 15 yr. Environmental factors have been implicated because the distribution of these tumors follows a regional, rather than a familial, pattern. However, decreased penetrance of a particular gene defect cannot be excluded. Because linkage or other traditional genetic analyses would not be appropriate to investigate the defect(s) associated with ACT in this population, we used comparative genomic hybridization (CGH) to screen for DNA sequence copy number changes in 9 nonfamilial ACT (6 carcinomas and 3 adenomas) from unrelated patients from this region. Six female (aged 10 months to 6 3/4 yr) and 3 male (1 1/12 to 3 1/4 yr) patients were studied. Three carcinomas were at stage I, 1 was at stage II, and another was at stage III. Two carcinomas had evidence of invasion of the vena cava, and 3 were more than 3 cm in size. All patients underwent surgical excision of their tumors; chemotherapy was administered to cancer patients. Currently, all patients are alive and in remission, with the exception of 1 patient with stage III cancer. High mol wt DNA was extracted from tumor tissue obtained at surgery and frozen at -70 C. This DNA was labeled and used for CGH according to standard procedures. Digital image analysis was performed to detect chromosomal gains or losses. CGH evaluation revealed extensive genetic aberrations in both adenomas and carcinomas; there were no significant differences relative to age, gender, size, or stage of the tumor (P > 0.1). Chromosomes and chromosomal regions 1q, 5p, 5q, 6p, 6q, 8p, 8q, 9q, 10p, 11q, 12q, 13q, 14q, 15q, 16, 18q, 19, and 20q demonstrated gains, whereas 2q, 3, 4, 9p, 11, 13q, 18, 20p, and Xq showed losses. The most striking finding was consistent copy number gain of chromosomal region 9q34 in 8 of the 9 tumors. We conclude that both benign and malignant ACT from southern Brazil show multiple genetic aberrations, including a consistent gain of chromosomal region 9q34. This genomic area may harbor genetic defects that predispose to ACT formation and are shared by the patients who were investigated in this study or are accumulated epigenetically under the influence of a common factor, such as an environmental mutagen.
Genome wide analysis of protein production load in Trichoderma reesei (2016)

The use of stoichiometric modelling can open a novel path for the improvement of protein production in T. reesei. Based on this we propose sulphur assimilation as a major limiting factor of protein production. As an organism with exceptional protein production capabilities modelling of T. reesei can provide novel insight also to other less productive organisms.
Quantitative Analysis of Chemotherapeutic Effects in Tumors Using In Vivo Staining and Correlative Histology (2005)

Quantitative analysis of histological slices revealed higher fluorescence and higher apoptotic count in the CS-LLC tumour images compared to the CR-LLC tumour images. These observations demonstrate that the annexinV-Cy5.5 probe sensed the chemotherapeutic effect of cyclophospamide and further confirmed in vivo FMT measurements.
Enhancing accuracy in energy measurement of nuclear spectroscopy signals by identification techniques (2002)

In nuclear spectroscopy, mixed analog-digital signal conditioning has proven to be useful to enhance the energy resolution of the instrument. Analog filters are used to preshape the signal in such a way as to minimise the requirements set to the analog-to-digital converter. However, it is necessary to accurately identify the singularities of the analog filter, to make the subsequent digital processing possible. In this paper, we address the problem of identifying the poles of the analog filter. We discuss the required precision of the identification method. We address the problem of the experimental measurement of the filter behaviour without hardware overhead. We implement a subspace-based identification method capable of determining the filter singularities with the required accuracy and precision. Experimental results show that a noticeable enhancement of the setup energy resolution is obtained.
A Comparison of Chlorinated Fluoride Glasses for Obtaining Red Upconversion Fluorescence in Praseodymium for a Three-Color Solid-State 3D Display (1996)

We have demonstrated an RGB solid-state 3D display based on two-step, two-frequency (TSTF) upconversion in bulk rare earth doped heavy metal halide glasses. 1 , 2 Figure 1a shows the basic two-step absorption process and figure 1b shows how two scanned pump lasers are made to intersect inside a bulk sample of active material to create three-dimensional images. Green upconversion fluorescence is obtained by pumping trivalent erbium doped glasses with 1.5 um and 850 nm, and blue from pumping Tm 3+ doped glasses with 800 nm and 1120 nm. Figure 2 shows the energy level diagrams of these three ions along with the respective resonant pump wavelengths and emission lines.
Spatial Characterization of Germanium-on-Silicon C-Band PIN Photodiodes (2007)

Spatially-resolved photoresponse and modulation measurements of vertically- illuminated germanium-on-silicon photodiodes are presented. It is shown that, even in a planar device, localized traps at the perimeter limit both quantum efficiency and modulation bandwidth.
On using CAD models to compute the pose of curved 3D objects (2002)

A new approach is presented for explicitly relating image observables to models of curved three-dimensional objects. This relationship is used for object recognition and positioning. Object models consist of collections of parametric surface patches. The image observables considered are raw range data, surface normals and Gaussian curvature, raw image contours, contour orientation and curvature, raw image intensity, and intensity gradient. Elimination theory provides a method for constructing an implicit equation that relates these observables to the three-dimensional position and orientation of object models. Determining the unknown parameters is reduced to a fitting problem between the implicit equation and served data points. A preliminary implementation is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Modeling of NOx Storage and Reduction for Diesel Exhaust Emission Control (2005)

&lt;div class="htmlview paragraph"&gt;A one-dimensional two-phase model of an adsorptive catalytic monolith reactor (used as Lean NOx Trap, LNT) is developed and analyzed. The model simulates the features of NOx storage and reduction (NSR), a periodic process involving the sequential trapping on a storage component and conversion of NOx to nitrogen under lean conditions found in the exhaust of lean burn and diesel vehicles. The effect of design and operating parameters, such as the lean and rich times and feed temperature, on NO&lt;sub&gt;2&lt;/sub&gt; conversion is examined. Using a relatively simple kinetic model and without any attempt to fit data, the LNT model predicts the dependencies of NO&lt;sub&gt;2&lt;/sub&gt; conversion on several feed parameters that are in good agreement with experimental observations.&lt;/div&gt;
Point representation for local optimization (2013)

In the context of stochastic search, once regions of high performance are found, having the property that small changes in the candidate solution correspond to searching nearby neighborhoods provides the ability to perform effective local optimization. To achieve this, Gray Codes are often employed for encoding ordinal points or discretized real numbers. In this paper, we present a method to label similar and/or close points within arbitrary graphs with small Hamming distances. The resultant point labels can be viewed as an approximate high-dimensional variant of Gray Codes. The labeling procedure is useful for any task in which the solution requires the search algorithm to select a small subset of items out of many. A large number of empirical results using these encodings with a combination of genetic algorithms and hill-climbing are presented.
The increasing complexity of glucocorticoid receptor signaling and regulation (2014)

Glucocorticoids, although being one of the eldest drugs in the clinic and despite their widespread usage for the treatment of inflammatory and immune disorders and cancer, have not yet come of age when it comes to a full understanding of how they work. The majority of the biological actions of glucocorticoid hormones are explained by a wide diversity in the cellular action mechanism of the hormone-activated Glucocorticoid Receptor (GR). All molecular mechanisms described in the current overview are not only complex, exhibiting an astonishing degree of gene- and tissue-specificity, but on top of this they are also non-exclusive. This layering of mechanisms makes it extremely difficult for researchers to extract the crucial pieces of information that would assist in a rational design of drugs with an improved therapeutic profile, i.e. a satisfying and maintained therapeutic response in the absence of the many incapacitating glucocorticoid-associated side effects, such as diabetes, osteoporosis, muscle wasting, depression etc. In direct correlation with increased glucocorticoid usage as observed in the clinic, the impetus and desire to reveal all of these mechanisms -and most importantly, to try to integrate them in a sensible manner for the sake of finding better alternatives- has never been stronger.
A General DNA-Gated Hydrogel Strategy for Selective Transport of Chemical and Biological Cargos (2021)

The selective transport of molecular cargo is critical in many biological and chemical/materials processes and applications. Although nature has evolved highly efficient <i>in vivo</i> biological transport systems, synthetic transport systems are often limited by the challenges associated with fine-tuning interactions between cargo and synthetic or natural transport barriers. Herein, deliberately designed DNA-DNA interactions are explored as a new modality for selective DNA-modified cargo transport through DNA-grafted hydrogel supports. The chemical and physical characteristics of the cargo and hydrogel barrier, including the number of nucleic acid strands on the cargo (i.e., the cargo valency) and DNA-DNA binding strength, can be used to regulate the efficiency of cargo transport. Regimes exist where a cargo-barrier interaction is attractive enough to yield high selectivity yet high mobility, while there are others where the attractive interactions are too strong to allow mobility. These observations led to the design of a DNA-dendron transport tag, which can be used to universally modify macromolecular cargo so that the barrier can differentiate specific species to be transported. These novel transport systems that leverage DNA-DNA interactions provide new chemical insights into the factors that control selective cargo mobility in hydrogels and open the door to designing a wide variety of drug/probe-delivery systems.
Correction to “Sugar-Based Polymers with Stereochemistry Dependent Degradability and Mechanical Properties” (2022)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to “Sugar-Based Polymers with Stereochemistry Dependent Degradability and Mechanical Properties”Connor J. StubbsConnor J. StubbsMore by Connor J. Stubbs, Joshua C. WorchJoshua C. WorchMore by Joshua C. Worchhttps://orcid.org/0000-0002-4354-8303, Hannah PrydderchHannah PrydderchMore by Hannah Prydderch, Zilu WangZilu WangMore by Zilu Wanghttps://orcid.org/0000-0002-5957-8064, Robert T. MathersRobert T. MathersMore by Robert T. Mathershttps://orcid.org/0000-0002-0503-4571, Andrey V. DobryninAndrey V. DobryninMore by Andrey V. Dobryninhttps://orcid.org/0000-0002-6484-7409, Matthew L. Becker*Matthew L. BeckerMore by Matthew L. Beckerhttps://orcid.org/0000-0003-4089-6916, and Andrew P. Dove*Andrew P. DoveMore by Andrew P. Dovehttps://orcid.org/0000-0001-8208-9309Cite this: J. Am. Chem. Soc. 2022, 144, 17, 7949–7950Publication Date (Web):April 26, 2022Publication History Published online26 April 2022Published inissue 4 May 2022https://doi.org/10.1021/jacs.2c03696Copyright © 2022 The Authors. Published by American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceCC: Creative CommonsBY: Credit must be given to the creatorNC: Only noncommercial uses of the work are permittedND: No derivatives or adaptations of the work are permittedArticle Views1029Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Su1871 Lactate Dehydrogenase-a Induction as an Early Metabolomic Marker of Colon Carcinogenesis: Potential Target for Chemoprevention (2012)

Our current study investigated the effect of PHLPP expression on the efficacy of chemotherapeutic drugs in colon cancer cells. Both PHLPP isoforms, PHLPP1 and PHLPP2, were either knocked down or overexpressed in SW480 and HT29 human colon cancer cells, and the rate of cell proliferation and apoptosis were measured upon drug treatment. Specifically, the cells were treated with different concentrations of oxaliplatin, PI3K inhibitor (LY294002), or rapamycin for 48 hours and cell proliferation was determined using MTS assays. Our results showed that knockdown of both PHLPP isoforms resulted in a decrease in the sensitivity to all drugs tested, whereas overexpression of PHLPP enhanced the anti-proliferation effect of these drugs. Moreover, we assessed the effect of the chemotherapy drugs in inducing cell death by monitoring the appearance of apoptotic markers including cleaved PARP and Caspase-3. Similarly, knockdown of both PHLPP isoforms rendered the cells resistant to apoptosis upon drug treatment. In summary, we have identified PHLPP as a critical factor in determining the drug sensitivity in the chemotherapeutic treatment of colon cancer. Adding yet another novel function of PHLPP and reasoning for the possible use of PHLPP as a therapeutic target in colon cancer.
Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years (2022)

Immune response induced by COVID-19 vaccine booster against delta and omicron variants was assessed in 65 adults (65-84 years old) early aftesr a first booster dose. An increase in SARS-CoV-2 neutralizing antibodies was shown in individuals not previously infected without evidence of an age-related effect, with lower increase in those infected before a single dose of primary vaccination. Of note, humoral response was observed only starting from the 5th day after the boost.
Dual functioned BiOF-coated Li[Li0.1Al0.05Mn1.85]O4 for lithium batteries (2009)

Spinel-type lithium manganese oxides have shown considerable promise for the positive electrode in lithium batteries but have suffered from poor performance at high temperatures (40–60 °C). The electrochemical properties of BiOF-coated spinel Li[Li0.1Al0.05Mn1.85]O4 at elevated temperatures (55 °C) were investigated. BiOF nanoparticles were well coated on spinel Li[Li0.1Al0.05Mn1.85]O4, as confirmed by scanning and transmission electron microscopy. The BiOF-coated spinel Li[Li0.1Al0.05Mn1.85]O4 electrode had excellent capacity retention at 55 °C, maintaining its initial discharge capacity of 96.1% after 100 cycles. This improved cycling performance was ascribed to the presence of the BiOF layer on the spinel particles, which prevented the infiltration of HF generated by the decomposition of electrolytic salt, LiPF6, in the electrolyte. This property resulted in a considerable reduction of manganese dissolution of the BiOF-coated spinel Li[Li0.1Al0.05Mn1.85]O4. Transmission electron microscopy of extensively cycled particles confirmed that the particle surface of the BiOF-coated Li[Li0.1Al0.05Mn1.85]O4 remained almost completely undamaged, whereas pristine spinel particles were severely deteriorated. In the present paper, we have tried to understand the role of the BiOF coating layer and why such coatings resulted in better battery performances, using BiOF-coated Li[Li0.1Al0.05Mn1.85]O4. The BiOF coating layer on the surface of Li[Li0.1Al0.05Mn1.85]O4 particles can be defined as follows; the oxyfluoride layer provides a strong protecting layer against HF attack and scavenges HF, thus resulting in reducing HF from the electrolyte. Synergistically, these actions resulted in the significantly improved high temperature cycling performances exhibited by the BiOF-coated Li[Li0.1Al0.05Mn1.85]O4.
Are Large-Scale 3D Models Really Necessary for Accurate Visual Localization? (2017)

International audience
Design Optimization of Transition Metamaterials (2010)

We report a detailed study of the effect of the graded index transition metamaterials design parameters on the resonant absorption of the obliquely incident electromagnetic wave in the vicinity of the zero index transition point(s).
Accurate Iterative Algorithm for Detection and the Signal AoA Estimation in Low SNR Region (2019)

The GLRT (Generalized Likelihood Ratio Test) method is applied for joint detection and the angle-of-arrive (AoA) estimation of an unknown signal in multi-element antenna arrays. The direct method of the maximum likelihood (ML) estimation of the power and the AoA of a signal with a plane wavefront and unknown temporal structure is considered. An efficient iterative procedure is proposed for implementation of this approach. For the useful signal detection the Neumann-Pearson criterion is applied at the final iteration step and the threshold value for the decision statistics is calculated by simulations. The performance characteristics of the proposed joint detection-estimation iterative algorithm are compared with three-step algorithm, which based on the sample correlation matrix eigenvectors and eigenvalues analysis. It was found that in high SNR region the accuracies of the proposed iterative algorithm and the three-step algorithm practically reach the low CRBs, but in low SNR region and the short sample sizes the iterative algorithm at 35% - 50% over performs the accuracy of the three-step algorithm.
VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells. (2012)

VOLUME 286 (2011) PAGES 43154–43163 PAGE 43156: The molecular mass of the marker in Fig. 1A was incorrect. It should be 150 kDa. The concentration of LPS used was incorrect. It should be 100 ng/ml and not 100 nm. This mistake appeared three times in the article: page 43155, right column, line 13; page 43156, legend to Fig. 1, line 2; and page 43156, left column, line 9.