gebhart/patrepeval huggingface dataset:
Serum biomarkers in people with chronic low back pain and Modic 1 changes: a case-control study (2019)

We aimed to compare serum biomarkers of inflammation, redox status and cartilage degradation between chronic low back pain (cLBP) patients with and without Modic 1 changes. We used a convenience sample of patients recruited from a single center, case-control study, conducted in a tertiary care center. From December, 2014 to May, 2016, 2,292 patients were consecutively screened, 34 met inclusion criteria and were prospectively enrolled in the present study. Cases (n = 13) were defined as patients with Modic 1 changes detected on MRI and controls (n = 21) as cLBP patients without (Modic 0). To assess serum biomarkers of inflammation, redox status and cartilage degradation, fasting serum samples were collected in a standardized manner and analyzed by immunoassays and spectrophotometry. Mean (95% CI) age was 44.1 (40.0-48.1) years and mean LBP duration was 72.5 (53.0-91.9) months. Serum biomarkers of inflammation (IL-1β, IL-6, IL-8 and TNF-α), redox status (total thiols, advanced oxidation protein products and carbonyl groups) and cartilage degradation (Coll2-1 and Coll2-1NO<sub>2</sub>) did not differ between cLBP patients with and without Modic 1 changes. In summary, we did not find any differences in serum biomarkers between cLBP patients with and without Modic 1 changes. Interpretation is limited by convenience sampling and small sample size.
Laser Doppler flowmetrie on small animal (2014)

Abstract We present a compact fundus camera designed to measure the blood flow in small animals based on laser Doppler flowmetry (LDF). The small animal is immobilized on a modified stereotaxic table and the pupil of the LDF device is superposed by translation to the pupil’s eye of the animal. Then rotation centered at the pupil is used to point the probing beam to the optic nerve head (ONH) or on retinal arteries (RA). LDF parameters Vel, Vol and F were assessed with a rotating teflon wheel simulating Doppler signal. Experiments were conducted on anesthetized adult male Wistar and Brown Normay rats. We demonstrated stable LDF parameters over 1 hours on RA and optic ONH for 6 and 10 rats respectively. Reproducibility is good for Vel on RA and ONH and moderate for Vol and F ONH. Transient ocular blood flow was blocked by increasing intra‐ocular pressure (IOP). Vel decreases significantly by 70% of baseline. Vel on RA was recorded during rat euthanasia. Vel decreases to the same level as for increased IOP. Vel measurement on RA are feasible, however measurement on ONH are more difficult probably due to a scare capillary network.
A Novel Weighted Memory Polynomial for Behavioral Modeling and Digital Predistortion of Nonlinear Wireless Transmitters (2015)

In this paper, a novel weighted memory polynomial (WMP)-based model is proposed for wireless transmitters and radio-frequency power amplifiers' (PAs) behavioral modeling and predistortion. The new model introduces an instantaneous-power-dependent weight function on the static and dynamic terms of the conventional memory polynomial (MP) model. Experimental validation in both modeling and predistortion contexts was performed on a PA prototype driven by a 20-MHz Long Term Evolution signal. The proposed model was assessed against the standard MP model. The experimental results demonstrate the superiority of the proposed polynomial in behavioral modeling applications as it results in up to 50% (3-dB) improvement in the normalized mean square error for the same number of coefficients. The model robustness was then validated by using a second test signal applied to two Doherty PAs using different transistor technologies. Furthermore, when applied for digital predistortion, the proposed WMP function achieves the same performance as the state-of-art MP while requiring approximately 50% less coefficients.
Phenanthroline Derivatives for Electron-transport Layer in Organic Light-emitting Devices (2009)

Abstract A series of novel phenanthroline derivatives (Phens) have been synthesized and their application to organic light-emitting devices (OLEDs) as an electron-transport layer was investigated. The OLEDs with a structure of ITO/α-NPD/Alq3/Phen/LiF/Al exhibited remarkable performances and lower operating voltages compared to Alq3-based device, indicating that Phens posses favorable electron-transport properties.
Nanoparticle enabled optical fibers to side-emit germicidal ultraviolet light for biofilm control (Conference Presentation) (2023)

Silica nanoparticle coating on 250 to 1000 um flexible quartz optical fiber facilitates side-emission of germicidal ultraviolet light (UV-C), which shows promise for disinfection of contaminated air, water, and surfaces. This work aims to develop an understanding of light interactions with the silica nanoparticles to allow more uniform side-emission of germicidal light along longer lengths of optical fibers. Two forms of light energy (refracted light and evanescent waves) are transmitted through optical fibers.
Intracellular Distribution of Free Potassium in Chironomus Salivary Glands (1975)

Potassium activities have been measured in the nucleus and cytoplasm of Chironomus salivary gland cells, using potassium-selective electrodes. The data provide the first rigorous evidence that potassium is at electrochemical equilibrium across the nuclear membrane. In addition, no difference in potassium chemical activity was found between nucleus and cytoplasm.
Preparation of N-Alkyl 2-Pyridones via a Lithium Iodide Promoted O- to N-Alkyl Migration: Scope and Mechanism (2012)

An efficient and inexpensive LiI-promoted O- to N-alkyl migration of 2-benzyloxy-, 2-allyloxy-, and 2-propargyloxypyridines and heterocycles is reported. The reaction produces the corresponding N-alkyl 2-pyridones and analogues under green, solvent-free conditions in good to excellent yields (30 examples, 20-97% yield). This method has been shown to be intermolecular and requires heat and lithium cation to occur.
Analog MIMO Communication for One-Shot Distributed Principal Component Analysis (2022)

A fundamental algorithm for data analytics at the edge of wireless networks is <i>distributed principal component analysis</i> (DPCA), which finds the most important information embedded in a distributed high-dimensional dataset by distributed computation of a reduced-dimension data subspace, called <i>principal components</i> (PCs). In this paper, to support one-shot DPCA in wireless systems, we propose a framework of analog MIMO transmission featuring the uncoded analog transmission of local PCs for estimating the global PCs. To cope with channel distortion and noise, two maximum-likelihood (global) PC estimators are presented corresponding to the cases with and without receive <i>channel state information</i> (CSI). The first design, termed coherent PC estimator, is derived by solving a Procrustes problem and reveals the form of regularized channel inversion where the regulation attempts to alleviate the effects of both receiver noise and data noise. The second one, termed blind PC estimator, is designed based on the subspace channel-rotation-invariance property and computes a centroid of received local PCs on a Grassmann manifold. Using the manifold-perturbation theory, tight bounds on the <i>mean square subspace distance</i> (MSSD) of both estimators are derived for performance evaluation. The results reveal simple scaling laws of MSSD concerning device population, data and channel <i>signal-to-noise ratios</i> (SNRs), and array sizes. More importantly, both estimators are found to have identical scaling laws, suggesting the dispensability of CSI to accelerate DPCA. Simulation results validate the derived results and demonstrate the promising latency performance of the proposed analog MIMO.
Speech transformation solutions (2006)

This paper outlines the background development of “intelligent” technologies such as speech recognition. Despite significant progress in the development of these technologies, they still fall short in many areas, and rapid advances in areas such as dictation are actually stalled. In this paper we have proposed semi-automatic solutions — smart integration of human and intelligent efforts. One such technique involves improvement to the speech recognition editing interface, thereby reducing the perception of errors to the viewer. Other techniques that are described in the paper are batch enrollment, which allows the user to reduce the amount of time required for enrollment, and content spotting, which can be used for applications that have repeated content flow, such as movies or museum tours. The paper also suggests a general concept of distributive training of speech recognition systems that is based on data collection across a network.
Complexity-constrained H.264 HD video coding through mode ranking (2009)

Video compression is a computation-intensive task and real-time implementation of state-of-the-art video standards is a challenge. In this paper we propose a complexity scalable framework to H.264/AVC prediction module since the “intra” and “inter” prediction steps are responsible for almost all computation complexity. The idea is to employ a subset of prediction modes instead of testing all modes recommended by H.264/AVC standard. Only the most “popular” prediction modes are ranked and tested until reaching a complexity budget. The ranking is done by sampling macroblocks of previous frames. Results show a negligible the quality loss while achieving large computational savings.
Exploration for Two-Dimensional Electrides via Database Screening andAb InitioCalculation (2014)

Inspired by the recent demonstration that Ca 2 N is a two-dimensional electride in which electrons near the Fermi level float between ionic layers, we have conducted a systematic search for 2D electrides by an approach combining crystal structure databases and ab initio electronic structure calculations. Starting from a set of working hypotheses, we have identified six 2D metallic electrides, of which one is nonmagnetic and five are nearly ferromagnetic ferrimagnets with a distinct spin texture. The latter five materials are the first magnetic electrides reported at ambient pressure.
Nuclear survivin predicts recurrence and poor survival in patients with resected nonsmall cell lung carcinoma (2005)

The nuclear presence of survivin may be an independent biomarker for disease recurrence and overall survival in patients with resected Stage I and II NSCLC.
[Are embryonic forms of NCAM homeobox receptors?]. (1992)

In a previous study we demonstrated that the homeobox peptide pAntp was able to penetrate into rat embryonic neurons in culture thus provoking their morphological differentiation [1]. In the present work we have started to analyse the process of penetration of the homeobox peptide. As illustrated in Figure 1 pAntp migrating as a homogeneous 7 kDa band could be recovered in the nuclear fraction 2 hrs. only after its addition to cultured embryonic neurons (lane 2). Penetration and nuclear targeting were quantitatively blocked by preincubating pAntp with its cognate recognition sequence present in the promoter of Hox-1.3 (lane 3) or by incubating the cells with an antibody directed against the NCAM-specific alpha 2-8 polysialic acid (lane 4). Similar inhibitions were observed when the peptide was incubated with double stranded DNA or added to cells deprived of alpha 2-8 polysialic acid by EndoN treatment (not shown). As illustrated in Figure 2, the strong pAntp-induced neurite growth was antagonized when pAntp internalization was prevented by the EndoN removal of PSA. This effect of EndoN was not due to the enzyme itself since morphological differentiation was not inhibited if EndoN was added after pAntp penetration (Fig. 2B). Polysialic acid is composed of long chains of neuraminic acids, each pyranose ring carrying a negatively charged carboxylic group linked to carbon in position 1. NMR studies of the molecule in solution have demonstrated that the alpha 2-8 link between each pyranose ring allows specific and stable helical conformation [2].(ABSTRACT TRUNCATED AT 250 WORDS)
Anticancer Therapeutics (2017)

Anticancer therapeutics : from drug discovery to clinical applications , Anticancer therapeutics : from drug discovery to clinical applications , کتابخانه مرکزی دانشگاه علوم پزشکی تهران
Development of a high-yield via-last through silicon via process using notchless silicon etching and wet cleaning of the first metal layer (2017)

A high-yield via-last through silicon via (TSV) process has been developed using notchless Si etching and wet cleaning of the first metal layer. In this process, the notching was suppressed by optimizing the deep Si etching conditions and wet cleaning was performed using an organic alkaline solution to remove reaction products generated by the etchback step on the first metal layer. By this process, a number of small TSVs (TSV diameter: 6 µm; TSV depth: 22 µm; number of TSVs: 20,000/chip) could be formed uniformly on an 8-in. wafer. The electrical characteristics of small TSVs formed by this via-last TSV process were investigated. The TSV resistance determined by four-terminal measurements was approximately 24 mΩ. The leakage current between the TSV and the Si substrate was 2.5 pA at 5 V. The TSV capacitance determined using an inductance–capacitance–resistance (LCR) meter was 54 fF, while the TSV yield determined from TSV chain measurements was high (83%) over an 8-in. wafer.
Depletion of the Ras Association Domain Family 1, Isoform A–Associated Novel Microtubule-Associated Protein, C19ORF5/MAP1S, Causes Mitotic Abnormalities (2007)

Ras association domain family 1, isoform A (RASSF1A) is a novel tumor suppressor gene that is found to be inactivated in more than 40 types of sporadic cancers. In addition, mouse Rassf1a knockout models have an increased frequency of spontaneous and induced tumors. The mechanisms by which RASSF1A exerts its tumor suppression activities or the pathways it can regulate are not yet fully understood. Using yeast two-hybrid system, we have previously identified C19ORF5/MAP1S as the major RASSF1A-interacting protein. C19ORF5 has two conserved microtubule-associated regions and may function to anchor RASSF1A to the centrosomes. In this study, we have analyzed the cellular functions of C19ORF5. By using small interfering RNA-mediated depletion and time-lapse video microscopy, we show that C19ORF5 knockdown causes mitotic abnormalities that consist of failure to form a stable metaphase plate, premature sister chromatid separation, lagging chromosomes, and multipolar spindles. We also show that a fraction of C19ORF5 localizes to the spindle microtubules. Additionally, we show here that C19ORF5 localizes to the microtubule-organizing centers during microtubule regrowth after nocodazole washout. Knockdown of C19ORF5 disrupts the microtubule-organizing center and results in microtubule nucleation from several sites. Whereas the localization of pericentrin is not affected, alpha- and gamma-tubulin localization and sites of nucleation are greatly altered by C19ORF5 depletion. This may indicate that C19ORF5 plays a role in anchoring the microtubule-organizing center to the centrosomes. In addition, we show that the NH2 terminus of C19ORF5 is essential for this process. This novel role for C19ORF5 could explain the resulting mitotic abnormalities that occur on its depletion and can potentially provide an underlying mechanism for the frequent centrosome and microtubule abnormalities detected in several cancers.
Parallel independent evolution of pathogenicity within the genus Yersinia (2014)

The genus Yersinia has been used as a model system to study pathogen evolution. Using whole-genome sequencing of all Yersinia species, we delineate the gene complement of the whole genus and define patterns of virulence evolution. Multiple distinct ecological specializations appear to have split pathogenic strains from environmental, nonpathogenic lineages. This split demonstrates that contrary to hypotheses that all pathogenic Yersinia species share a recent common pathogenic ancestor, they have evolved independently but followed parallel evolutionary paths in acquiring the same virulence determinants as well as becoming progressively more limited metabolically. Shared virulence determinants are limited to the virulence plasmid pYV and the attachment invasion locus ail. These acquisitions, together with genomic variations in metabolic pathways, have resulted in the parallel emergence of related pathogens displaying an increasingly specialized lifestyle with a spectrum of virulence potential, an emerging theme in the evolution of other important human pathogens.
Synthetic control over intra- and intermolecular charge transfer can turn on the fluorescence emission of non-emissive coumarin (2016)

Photoinduced charge transfer was exploited in coumarin compounds to obtain strong fluorescence emission.
Initial results of a mouse brain PET insert with a staggered 3-layer DOI detector (2021)

<i>Objective.</i>Small animal positron emission tomography (PET) requires a submillimeter resolution for better quantification of radiopharmaceuticals. On the other hand, depth-of-interaction (DOI) information is essential to preserve the spatial resolution while maintaining the sensitivity. Recently, we developed a staggered 3-layer DOI detector with 1 mm crystal pitch and 15 mm total crystal thickness, but we did not demonstrate the imaging performance of the DOI detector with full ring geometry. In this study we present initial imaging results obtained for a mouse brain PET prototype developed with the staggered 3-layer DOI detector.<i>Approach.</i>The prototype had 53 mm inner diameter and 11 mm axial field-of-view. The PET scanner consisted of 16 DOI detectors each of which had a staggered 3-layer LYSO crystal array (4/4/7 mm) coupled to a 4 × 4 silicon photomultiplier array. The physical performance was evaluated in terms of the NEMA NU 4 2008 protocol.<i>Main Results.</i>The measured spatial resolutions at the center and 15 mm radial offset were 0.67 mm and 1.56 mm for filtered-back-projection, respectively. The peak absolute sensitivity of 0.74% was obtained with an energy window of 400-600 keV. The resolution phantom imaging results show the clear identification of a submillimetric rod pattern with the ordered-subset expectation maximization algorithm. The inter-crystal scatter rejection using a narrow energy window could enhance the resolvability of a 0.75 mm rod significantly.<i>Significance.</i>In an animal imaging experiment, the detailed mouse brain structures such as cortex and thalamus were clearly identified with high contrast. In conclusion, we successfully developed the mouse brain PET insert prototype with a staggered 3-layer DOI detector.
Convenient Construction of Cyclopentanones via "Cyclopentannulation" of Carbonyls (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConvenient Construction of Cyclopentanones via "Cyclopentannulation" of CarbonylsDavid P. Provencal and James W. LeahyCite this: J. Org. Chem. 1994, 59, 18, 5496–5498Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/jo00097a070https://doi.org/10.1021/jo00097a070research-articleACS PublicationsRequest reuse permissionsArticle Views341Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Page segmentation using thinning of white areas (1998)

Page segmentation is a process used to extract such components as columns, figures, tables, and photos from an image of a document. This article proposes a page segmentation technique that is stable, irrespective of component shape or tilted document image, based on analyzing the white region (background) of the document image. When we process a document that has non-rectangular and tilted components, the boundary of the components, that is, the white region, takes any shape. Thus, important questions include how to express white regions and how to process them. The proposed method uses thin lines that are extracted by thinning as an expression of white regions. Based on this expression of white regions, page segmentation is defined as extracting loops that surround the components. The proposed method extracts loops by eliminating unnecessary thin lines, for example, those that represent line spacing and character spacing. We try to use not only the feature of white regions, but also those of black regions, and to process several kinds of document layout. This paper examines the effectiveness and limitations of the proposed method based on experimental results that are taken from 80 sample images that are tilted from 0 to 45 degrees. © 1998 Scripta Technica. Syst Comp Jpn, 29(3): 59–68, 1998
Stabilization of an integrated laser with an 8 mL Fabry-Pérot optical reference cavity (2022)

We present an integrated laser locked to an 8 mL microfabricated optical reference cavity with 1 Hz integrated linewidth, sub-10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−14</sup> fractional frequency instability and thermal noise limited performance to ~1 kHz offset. This work assembles the primary components of a fully integrated narrow-linewidth laser source.
Alignment maps and homology analysis of the J-C intron in human, mouse, and rabbit immunoglobulin kappa gene. (1985)

The statistically significant shared oligonucleotides (block identities) of the intervening region (J5-C) in the human, mouse, and rabbit immunoglobulin (Ig)-kappa gene were determined. These identities maintain their order (do not cross) and never connect with any Ig-kappa segment external to the intron region. The two regions of pronounced similarity are (1) the vicinity of the established enhancer element (Queen and Baltimore 1983) and (2) a 200-bp region approximately 1 kb upstream that we have labeled the second enhancer element. Similarity is strong between the human and mouse sequences in the neighborhood of the first enhancer element and more pronounced between the human and rabbit sequences in the vicinity of the second enhancer region. The overall extent of similarity between the mouse and rabbit sequences is less than that between the human and mouse sequences and that between the human and rabbit sequences. All close and large dyad-symmetry pairings were ascertained and their possible relations to the enhancer elements discussed.