gebhart/patrepeval huggingface dataset:
Anti-BCMA immunotoxins produce durable complete remissions in two mouse myeloma models (2019)

Multiple myeloma (MM) is a B cell malignancy for which new treatments are urgently needed. The B cell maturation antigen (BCMA) is a lineage-restricted differentiation protein highly expressed on myeloma. Recombinant immunotoxins (RITs) are proteins composed of the Fv or Fab portion of an antibody fused to a bacterial toxin. We previously treated H929 myeloma s.c. tumors with anti-BCMA immunotoxins, very active on killing cultured cells, and observed tumor growth inhibition but not complete tumor responses. To determine if immunotoxins were more active against cells growing in the bone marrow (BM), the normal location of myeloma cells, we developed a BM mouse model that is more relevant to human disease. H929 cells were transfected with luciferase and GFP, enriched by flow, recycled through the BM of a mouse, and injected IV into nonobese diabetic scid γ mice (NSG) mice. A second myeloma mouse model used the MM.1S-GFP-luc cell line. Mice were treated IV with immunotoxins, and the tumor burden was assessed using bioluminescence imaging. We achieved complete durable remissions when treating mice with H929-GFP-luc cells with anti-BCMA RITs both leptomycin B-75 (LMB-75) [anti-BCMA-disulfide-stabilized (ds)-Fv-PE24] (where PE represents Pseudomonas exotoxin A) or LMB-70 (anti-BCMA-Fab-PE24) given every other day for 5-d (QOD×5) doses beginning on day 4 or day 8. Mice were disease free at 3 months; untreated mice became moribund around day 40. We also achieved long-term responses using the MM.1S-GFP-luc myeloma cell line. Treatment with an 1.5 mg/kg LMB-75 QOD×5 anti-BCMA RIT beginning on day 4 caused the complete disappearance of tumors for 80 days. To summarize, LMB-75 and LMB-70, our anti-BCMA RITs, induced complete durable responses in two myeloma models.
Non-isotropy Regularization for Proxy-based Deep Metric Learning (2022)

Deep Metric Learning (DML) aims to learn representation spaces on which semantic relations can simply be expressed through predefined distance metrics. Best performing approaches commonly leverage class proxies as sample stand-ins for better convergence and generalization. However, these proxy-methods solely optimize for sample-proxy distances. Given the inherent non-bijectiveness of used distance functions, this can induce locally isotropic sample distributions, leading to crucial semantic context being missed due to difficulties resolving local structures and intraclass relations between samples. To alleviate this problem, we propose non-isotropy regularization ($\mathbb{NIR}$) for proxy-based Deep Metric Learning. By leveraging Normalizing Flows, we enforce unique translatability of samples from their respective class proxies. This allows us to explicitly induce a non-isotropic distribution of samples around a proxy to optimize for. In doing so, we equip proxy-based objectives to better learn local structures. Extensive experiments highlight consistent generalization benefits of $\mathbb{NIR}$ while achieving competitive and state-of-the-art performance on the standard benchmarks CUB200-2011, Cars196 and Stanford Online Products. In addition, we find the superior convergence properties of proxy-based methods to still be retained or even improved, making $\mathbb{NIR}$ very attractive for practical usage. Code available at https://github.com/ExplainableML/NonIsotropicProxyDML.
Targeting the platelet-derived growth factor receptor α with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: Implications as a potential therapeutic target (2005)

Platelet-derived growth factor receptor alpha (PDGFRalpha) is a type III receptor tyrosine kinase that is expressed on a variety of tumor types. A neutralizing monoclonal antibody to human PDGFRalpha, which did not cross-react with the beta form of the receptor, was generated. The fully human antibody, termed 3G3, has a Kd of 40 pmol/L and blocks both PDGF-AA and PDGF-BB ligands from binding to PDGFRalpha. In addition to blocking ligand-induced cell mitogenesis and receptor autophosphorylation, 3G3 inhibited phosphorylation of the downstream signaling molecules Akt and mitogen-activated protein kinase. This inhibition was seen in both transfected and tumor cell lines expressing PDGFRalpha. The in vivo antitumor activity of 3G3 was tested in human glioblastoma (U118) and leiomyosarcoma (SKLMS-1) xenograft tumor models in athymic nude mice. Antibody 3G3 significantly inhibited the growth of U118 (P=0.0004) and SKLMS-1 (P <0.0001) tumors relative to control. These data suggest that 3G3 may be useful for the treatment of tumors that express PDGFRalpha.
T1-Weighted MR imaging of liver tumor by gadolinium-encapsulated glycol chitosan nanoparticles without non-specific toxicity in normal tissues (2016)

Herein, we have synthesized Gd(iii)-encapsulated glycol chitosan nanoparticles (Gd(iii)-CNPs) for tumor-targeted T1-weighted magnetic resonance (MR) imaging. The T1 contrast agent, Gd(iii), was successfully encapsulated into 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-modified CNPs to form stable Gd(iii)-encapsulated CNPs (Gd(iii)-CNPs) with an average particle size of approximately 280 nm. The stable nanoparticle structure of Gd(iii)-CNPs is beneficial for liver tumor accumulation by the enhanced permeation and retention (EPR) effect. Moreover, the amine groups on the surface of Gd(iii)-CNPs could be protonated and could induce fast cellular uptake at acidic pH in tumor tissue. To assay the tumor-targeting ability of Cy5.5-labeled Gd(iii)-CNPs, near-infrared fluorescence (NIRF) imaging and MR imaging were used in a liver tumor model as well as a subcutaneous tumor model. Cy5.5-labeled Gd(iii)-CNPs generated highly intense fluorescence and T1 MR signals in tumor tissues after intravenous injection, while DOTAREM®, the commercialized control MR contrast agent, showed very low tumor-targeting efficiency on MR images. Furthermore, damaged tissues were found in the livers and kidneys of mice injected with DOTAREM®, but there were no obvious adverse effects with Gd(iii)-CNPs. Taken together, these results demonstrate the superiority of Gd(iii)-CNPs as a tumor-targeting T1 MR agent.
Velocity Profile measurements in two-phase flow using multi-wave sensors (2009)

Two-phase flow has been recognized as one of the most important phenomena in fluid dynamics. In addition, gas-liquid two-phase flow appears in various industrial fields such as chemical industries and power generations. In order to clarify the flow structure, some flow parameters have been measured by using many effective measurement techniques. The velocity profile as one of the important flow parameter, has been measured by using ultrasonic velocity profile (UVP) technique. This technique can measure velocity distributions along a measuring line, which is a beam formed by pulse ultrasounds. Furthermore, a multi-wave sensor can measure the velocity profiles of both gas and liquid phase using UVP method. In this study, two types of multi-wave sensors are used. A sensor has cylindrical shape, and another one has square shape. The piezoelectric elements of each sensor have basic frequencies of 8 MHz for liquid phase and 2 MHz for gas phase, separately. The velocity profiles of air-water bubbly flow in a vertical rectangular channel were measured by using these multi-wave sensors, and the validation of the measuring accuracy was performed by the comparison between the velocity profiles measured by two multi-wave sensors.
Co-integration of filters and waveguide to microstrip transitions using the foam technology (2004)

In this paper, we discuss about original designs of passive structures integrated within a common housing foam material. Milling and pressed moulding techniques are used to produce particular shapes (ridge, cavities,..) then allowing a complete integration and simultaneous association of passive functions (filter, waveguide, microstrip line, polariser..). The foam material is considered either as a supporting structure or as a grooved cavity with internal elements. Experimental as well as simulated results are presented, with original association of volumic and planar functions.
220MV-900MV 794/584/754 GBPS/W Reconfigurable GF(24)2 AES/SMS4/Camellia Symmetric-Key Cipher Accelerator in 14NM Tri-Gate CMOS (2018)

A reconfigurable AES/SMS4/Camellia symmetric-key cipher accelerator fabricated in 14nm CMOS achieves 3.17/2.68/3.17 Gbps throughput at 750mV, 25°C. Hybrid GF(2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> ) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> Sbox-based unified datapath with in-line key expansion, polynomial optimization, scaled affine transform assisted multiply-less MixColumns with key-precompute, and shared round constant circuits result in a 9152 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> design, a 29% area reduction over conventional separate implementations. Look-up-table (LUT) elimination enables sub-threshold operation down to 220mV, with 794/584/754Gbps/W peak energy-efficiency measured at 240mV.
Feasibility Analysis of Surface-to-reservoir Electromagnetics for Waterflood Monitoring (2011)

We analyze, by means of a synthetic model, the feasibility of detecting the electromagnetic (EM) field variations related to waterflood in a large Saudi Arabian Jurassic reservoir. We utilize a 3D structural reservoir model and derive the geoelectric parameters from careful analysis of well logs acquired at the Saudi Aramco Technology Test Site. The resistivity variations as a result of water flooding are derived using characteristic parameters and injection water salinity of the field. We model a geometry consisting of a radial surface galvanic source and four EM receivers located at the reservoir level. The full EM field is modeled in the time domain and the horizontal and vertical electric field (Ex and Ez) and horizontal crossline magnetic field (dBy/dt) components are interpreted and analyzed. Results indicate that all the modeled fields show substantial variations as a result of water saturation changes with field strength values above the noise level expected for EM sensors. The results will be validated next by modeling more complex and realistic 3D patterns of water saturation in the reservoir, as derived directly from reservoir simulation. Given that one of the modeled components is the vertical electric field, the electrical anisotropy of the overburden is expected to play a significant role in the response and will be taken into consideration in the next round of modeling. Modeling results also suggest that the type of borehole EM sensors currently available in the industry may not be adequate for surface-to-reservoir EM applications.
Cloning and characterization of mouse GABAC receptor subunits (1998)

Retinal gamma-aminobutyric acid type C (GABA[C]) receptors are believed to consist of rho subunits. The pharmacological properties of GABA(C) receptors appear to vary among different species. Since the mouse is an important model for gene targeting and behavioral studies, this study was aimed at cloning rho subunits in the mouse. Here we report the isolation of two full length cDNAs corresponding to mouse rho1 and rho2 subunits. In contrast to the rat, both subunits in mouse are able to form homomeric receptors, but only rho2 receptors are insensitive to picrotoxinin. Mouse rho1 and rho2 also co-assemble to form heteromeric receptors. These findings form the basis for further study on GABA(C) receptors using the mouse model.
[Male Accessory Gland Infections (MAGI): patient questionnaire and additional ultrasonography criteria]. (2008)

Male Accessory Gland Infections (MAGI) refers to a syndrome that has generated considerable debate recently in relation to its possible role in causing certain acquired conditions of male fertility. A further characterization of the syndrome based on symptoms and ultrasonographic findings has therefore become necessary. The article examines the practical outcome of the use of a new questionnaire designed specifically for patients with MAGI and that inquires about: 1) the range of associated symptoms (pelvic discomfort, micturition disorders, sexuality, quality of life); 2) the possible relationship between progress of prostate inflammation/infection or retrograde spread of inflammation/infection to the seminal vesicles and/or the epididymis and symptom severity; 3) combined sequential medical therapy based on the quality of the anamnestic changes the patient reports on the questionnaire. The need to improve targeted diagnosis, the requisite for correct diagnostic characterization of this patient category, has drawn increasing attention to non-conventional sonographic aspects, thus permitting the following hypotheses: 1) a possible role of characterization according to non-conventional criteria in terms of diagnostic specificity and sensitivity; 2) a possible role of sonography at initial diagnosis and during follow-up, particularly in relation to the possibility of identifying by ultrasonography the category of patients who test negative at microbiological analysis after treatment, despite continued symptoms with or without abnormal conventional parameters.
Network Simplification: The Gaussian diamond network with multiple antennas (2011)

We consider the N-relay Gaussian diamond network when the source and the destination have n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> ≥ 2 and n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> ≥ 2 antennas respectively. We show that when n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> = n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> = 2 and when the individual MISO channels from the source to each relay and the SIMO channels from each relay to the destination have the same capacity, there exists a two relay sub-network that achieves approximately all the capacity of the network. To prove this result, we establish a simple relation between the joint entropies of three Gaussian random variables, which is not implied by standard Shannon-type entropy inequalities.
Electrochemical microfluidic pumps based on super absorbing polymers (2007)

S.1504-1506
In-process improvement through defect data interpretation (1994)

An approach that involves both automatic and human interpretation to correct the software production process during development is becoming important in IBM as a means to improve quality and productivity. A key step of the approach is the interpretation of defect data by the project team. This paper uses examples of such correction to evaluate and evolve the approach, and to inform and teach those who will use the approach in software development. The methodology is shown to benefit different kinds of projects beyond what can be achieved by current practices, and the collection of examples discussed represents the experiences of using a model of correction.
Integrated profiling of diffuse large B‐cell lymphoma with 7q gain (2011)

To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60 years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.
Recombinant human tumor necrosis factors alpha and beta stimulate fibroblasts to produce hemopoietic growth factors in vitro. (1988)

The influences of TNF alpha and TNF beta were evaluated for their stimulatory and inhibitory effects on in vitro colony formation by human bone marrow granulocyte-macrophage (CFU-GM), erythroid (BFU-E), and multipotential (CFU-GEMM) progenitor cells. Both TNF alpha and TNF beta induced fibroblasts to produce stimulators of CFU-GM, BFU-E, and CFU-GEMM in a dose-dependent fashion. Similar results were seen when equivalent concentrations of TNF alpha and TNF beta were used. Prior incubation of the TNF alpha and TNF beta with their respective antibodies inactivated the ability of the TNF preparations to induce the release of granulocyte-macrophage, erythroid, and multipotential colony-stimulating activity from fibroblasts. In addition, incubation of the TNF-induced fibroblast supernatant with antibody before colony assay resulted in enhanced colony formation, suggesting that the TNF carried over into the colony assay suppressed colony formation. Additional proof of this suppression by TNF was evident when TNF was added directly to the CFU-GM, BFU-E, and CFU-GEMM colony assays. IL-1 does not appear to function as an intermediary in growth factor production by fibroblasts stimulated with TNF because antibody to IL-1 displayed no effect. Furthermore, assay of TNF-induced fibroblast supernatant was negative for IL-1. These results suggest that TNF alpha and TNF beta exert both a positive and negative influence on in vitro hemopoietic colony formation.
Distribution of atrial low voltage induced by vein of Marshall ethanol infusion (2022)

VOM ethanol infusion typically locates at the inferior ridge and the adjacent half of the mitral isthmus. Low-voltage extensions can be anticipated but not guaranteed by the presence of visible anastomosis of the VOM with roof or posterior veins.
Next-Generation Continuous Metabolite Sensing toward Emerging Sensor Needs (2021)

This article discusses the emergent biosensor technology focused on continuous biosensing of metabolites by non-invasive sampling of body fluids emphasized on physiological monitoring in mobility-constrained populations, resource-challenged settings, and harsh environments. The boom of innovative ideas and endless opportunities in healthcare technologies has transformed traditional medicine into a sustainable link between medical practitioners and patients to provide solutions for faster disease diagnosis. The future of healthcare is focused on empowering users to manage their own health. The confluence of big data and predictive analysis and the internet of things (IoT) technology have shown the potential of converting the abundant health profile data amassed from medical diagnosis of patients into useable information, whilst allowing caregivers to provide suitable treatment plans. The implementation of the IoT technology has opened up advanced approaches in real-time, continuous, remote monitoring of patients. Wearable, point-of-care biosensors are the future roadmap to providing direct, real-time information of health status to the user and medical professionals in this digitized era.
Two-photon absorption based optical recording in organic planar waveguide (1995)

Two-photon absorption based three-dimensional (3-D) memories have been investigated and demonstrated over the last years, providing potentials for high memory densities and parallel access for fast data rates. Figure 1 illustrates the basic principle by which information is stored and retrieved in these 3-D memories. Two photons with appropriate combined energy (for example, λ = 1064 and 532 nm) are introduced into the memory and are absorbed simultaneously by the memory material which consists of spirobenzopyran (SP) in a PMMA host matrix). 1 The simultaneous absorption of the two photons by the photochromic molecule results in a bond dissociation transforming it into a new form with different properties, including the absorption spectrum as shown in Fig. 1. These two different molecular forms are defined as the non-written and written forms of the memory. When properly excited, the new molecular form emits fluorescence which can be detected during the read-out process. The peak fluorescence occurs at 660 nm.
DNA methylation signature of human fetal alcohol spectrum disorder (2016)

These findings suggested that prenatal alcohol exposure is associated with distinct DNA methylation patterns in children and adolescents, raising the possibility of an epigenetic biomarker of FASD.
Optical characterization of ZnSe/ZnS strained-layer superlattices grown on CaF2 substrates (1991)

Growth of ZnSe/ZnS strained-layer superlattices on CaF2 substrates has been demonstrated for the first time. Optical transmission measurements at 77 K were carried out to investigate the optical property of excitons confined in ZnSe/ZnS multiquantum wells. Two exciton peaks related to the transitions between n=1 electron and heavy hole (Ee–hh) and between n=1 electron and light hole (Ee–lh) were observed in the transmission spectra. The energy seperation between Ee–hh and Ee–1h increases with decreasing the ZnSe layer thickness, which is due to the increase of strain in the ZnSe well layer. From the relationship between ZnSe well layer thickness and peak energy, the quantum size effect in the quantum well was also confirmed.
Thyroxine regulation of monolysocardiolipin acyltransferase activity in rat heart (2000)

Treatment of rats with thyroxine has been shown to elevate the biosynthesis and content of cardiolipin in the heart [Cao, Cheng, Angel and Hatch (1995) Biochim. Biophys. Acta 1256, 241-244]. Treatment with thyroxine resulted in a 1.8-fold increase (P<0.025) in [1-(14)C]linoleate and a 1.7-fold increase (P<0.025) in [1-(14)C]oleate incorporated into cardiolipin in perfused hearts, compared with controls. The mechanism for the elevation in incorporation of unsaturated fatty acids into cardiolipin was a 1. 6-fold (P<0.025) increase in mitochondrial monolysocardiolipin acyltransferase activity. The results demonstrate that the acylation of cardiac monolysocardiolipin is regulated by thyroid hormone. Thus an elevation in cardiolipin biosynthesis is accompanied by an elevation in monolysocardiolipin acyltransferase activity to maintain the appropriate molecular species composition of cardiolipin in the cardiac mitochondrial membrane. We postulate that monolysocardiolipin acyltransferase might be a rate-limiting enzyme for the molecular remodelling of cardiolipin in the heart.
<title>Advanced e-beam lithography system in producing high-quality reticle for 64M-DRAM</title> (1992)

Reticle specifications (line width accuracy, pattern stitching accuracy, overlay accuracy) required for 64M-DRAM are 0.05 for individual items. It is very hard for current Electron Beam Lithography systems (EBL) to produce high quality reticles and keep through-put the same as the current EBL. In order to satisfy 64M-DRAM application the HL-700M has thoroughly been evaluated and modified to meet 0.05 ?m specification. A highly accurate electron beam correction program and a bordering exposure program were developed in order to improve line width accuracy. A rigid stage chamber construction and temperature control units have been developed in order to improve stitching and overlay accuracy. Line width accuracy (0.05 ?m) was confirmed. Stitching accuracy (0. 05 ?m) and overlay accuracy (0. 06 ?m) were obtained, which is 2 times the accuracy of the current HL-700M. The advanced HL-700M is under development for improvements.
Air-ground channel measurements &amp; modeling for UAS (2013)

This slides presentations discussed the following: accurate AG channel models important to UAS; dual-band, SIMO measurement system developed for AG channel measurements; flight tests Spring/Summer 2013 in multiple environments; empirical AG channel model development following data analysis.
Diastereoselective Synthesis of 1,2,3‐Substituted Potassium Cyclopropyl Trifluoroborates via an Unusual Zinc—Boron Exchange. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.