gebhart/patrepeval huggingface dataset:
Variability of aluminum concentrations in organs and whole bodies of smallmouth bass (Micropterus dolomieui) (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVariability of aluminum concentrations in organs and whole bodies of smallmouth bass (Micropterus dolomieui)William G. Brumbaugh and Donald A. KaneCite this: Environ. Sci. Technol. 1985, 19, 9, 828–831Publication Date (Print):September 1, 1985Publication History Published online1 May 2002Published inissue 1 September 1985https://pubs.acs.org/doi/10.1021/es00139a010https://doi.org/10.1021/es00139a010research-articleACS PublicationsRequest reuse permissionsArticle Views58Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Overview of Operational Ocean Forecasting in the US Navy: Past, Present, and Future (2014)

A popular cigarette advertisement from the 1960s exclaimed, "You've come a long way, Baby!" That sentiment could be applied to Naval Oceanography. The US Navy has navigated the course of developing prediction technology over many fundamental shifts in global geopolitics while addressing the evolving challenges at the forefront of the oceanography mission to ensure the safety of the nation's armed forces. Originally motivated by Soviet-era submarine programs, accurate acoustic prediction necessitated forecasting the positions of ocean fronts and eddies. Since then, the scope of Naval Oceanography has expanded to encompass a littoral focus, including applications that assist Navy SEa Air and Land (SEAL) teams, amphibious vehicle landings, and mine warfare. The fundamental physics governing the universe remains unchanged and so has the Navy's need to understand ocean physics, build numerical representations, connect to data streams, and assimilate observations in order to provide forecasts addressing the challenges of today and tomorrow. A well-planned course is no accident, and the Navy's leading edge in ocean prediction is the result. This paper provides a description of the path to this leading edge, a synthesis of the current operational architecture that enables Naval Oceanography, an analysis of the triumphs of the last 10 years that are part of today's oceanography portfolio, and a prediction of what the next 10 years holds for Naval Oceanography.
A study on image features using intensity profile for cortical dysplasia degree estimation (2010)

Cortical dysplasia is a congenital anomaly of cerebral cortex. It accompanies considerable number of pediatric intractable epilepsy patients. Therefore, it is very effective to detect cortical dysplasia lesions and to estimate dysplasia degree quantitatively in pediatric brain MR images for planning treatment. However, image features on the pediatric brain MR images of cortical dysplasia aren't clarified. This paper proposed the estimation method using intensity profile by detecting cortical dysplasia in pediatric brain MR images. The experimental results for three subjects with cortical dysplasia showed that the proposed method detected cortical dysplasia lesions with a mean sensitivity of 90.9 %, a mean specificity of 93.1 %, and a mean efficiency of 92.0%.
Substitute Valuations with Divisible Goods (2006)

In a companion paper, we showed that weak and strong notions of substitutes in economies with discrete goods have dierent implications for auction theory and equilibrium theory. In contrast, for the divisible goods case with concave valuations, natural extensions of these concepts coincide. Concave substitute valuations are characterized by submodularity of the dual profit function over nonlinear prices and are robust with respect to additive concave perturbations, which extends a related notion of robustness established for complements, as in Milgrom (1994). When all bidders have concave substitute valuations, the Vickrey outcome is in the core but the law of aggregate demand, which holds for strong substitutes in discrete economies, can fail.
Supplementary Table S1 from ER-851, a Novel Selective Inhibitor of AXL, Overcomes Resistance to Antimitotic Drugs (2023)

&lt;p&gt;Supplementary Table S1&lt;/p&gt;
Osler-Weber-Rendu Disease Associated with Hepatic Involvement and High Output Heart Failure (1990)

Case Reports
AMG 479, a fully human anti–insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells (2009)

Pancreatic carcinoma is a leading cause of cancer deaths, and recent clinical trials of a number of oncology therapeutics have not substantially improved clinical outcomes. We have evaluated the therapeutic potential of AMG 479, a fully human monoclonal antibody against insulin-like growth factor (IGF) type I receptor (IGF-IR), in two IGF-IR-expressing pancreatic carcinoma cell lines, BxPC-3 and MiaPaCa2, which also differentially express insulin receptor (INSR). AMG 479 bound to IGF-IR (K(D) 0.33 nmol/L) and blocked IGF-I and IGF-II binding (IC(50) < 0.6 nmol/L) without cross-reacting to INSR. AMG 479 completely inhibited ligand-induced (IGF-I, IGF-II, and insulin) activation of IGF-IR homodimers and IGF-IR/INSR hybrids (but not INSR homodimers) leading to reduced cellular viability in serum-deprived cultures. AMG 479 inhibited >80% of basal IGF-IR activity in BxPC-3 and MiaPaCa2 xenografts and prevented IGF-IR and IGF-IR/INSR hybrid activation following challenge with supraphysiologic concentrations of IGF-I. As a single agent, AMG 479 inhibited (∼ 80%) the growth of pancreatic carcinoma xenografts, and long-term treatment was associated with reduced IGF-IR signaling activity and expression. Efficacy seemed to be the result of two distinct biological effects: proapoptotic in BxPC-3 and antimitogenic in MiaPaCa2. The combination of AMG 479 with gemcitabine resulted in additive inhibitory activity both in vitro and in vivo. These results indicate that AMG 479 is a clinical candidate, both as a single agent and in combination with gemcitabine, for the treatment of patients with pancreatic carcinoma
Rates of Infection after Spine Surgery Based on 108,419 Procedures (2009)

Smith, Justin S. M.D., Ph.D.; Shaffrey, Christopher I. M.D.; Sansur, Charles A. M.D., M.H.Sc.; Berven, Sigurd M.D.; Broadstone, Paul A.; Choma, Theodore; Goytan, Michael; Noordeen, Hilali; Knapp, D. Raymond; Hart, Robert M.D.; Zeller, Rienhard D.; Donaldson, William F.; Polly, David W. M.D.; Perra, Joseph; Boachie-Adjei, Oheneba
Kinetics of viremia and acute liver injury in relation to outcome of neonatal woodchuck hepatitis virus infection (2004)

The kinetics of serum viral responses and acute liver injury were studied during neonatal woodchuck hepatitis virus (WHV) infection in relation to the chronic or resolved outcome. The mean concentrations of serum WHV DNA and surface antigen were significantly higher by week 10 post infection in chronic infections compared to resolving infections, and diverged even further by the time of peak viral load development in serum (week 12). After week 12, these viral markers were detected less frequently with time and at lower concentrations in the resolved outcome. In both outcomes, mean serum activities of hepatic enzymes became increased significantly above baseline by weeks 10-12, peaked at week 14, and normalized by weeks 20-22, thus indicating transient acute liver injury. The increasing liver injury responses were comparable between outcomes at week 12, when serum viral load was markedly higher in the developing chronic infections. This suggested a deficiency in early non-cytolytic control of infection in the chronic outcome. At week 14, liver injury was significantly greater in the resolved outcome and associated with higher mean Fas ligand (FasL) and perforin messenger RNAs (mRNAs) in liver compared to the chronic outcome. This indicated greater immune-mediated killing of infected hepatocytes during resolution. Thus, chronicity as an outcome of neonatal WHV infection develops relatively early during the acute phase of infection due to reduced immune-mediated clearance of infected hepatocytes by both cytolytic and non-cytolytic processes.
Supplementary Figure 2C from Molecular Triage of Premalignant Lesions in Liquid-Based Cervical Cytology and Circulating Cell-Free DNA from Urine, Using a Panel of Methylated Human Papilloma Virus and Host Genes (2023)

&lt;p&gt;MethylScape - Large scale and close up visualization of HPV methylome. Large-scale view shows exact or smoothed (bsmooth) methylation levels along the HPV genome/contigs. Close-up view shows bisulfite 'alignments' of individual CpG methylation sites.&lt;/p&gt;
Web-Scale Semantic Product Search with Large Language Models (2023)

Abstract Dense embedding-based semantic matching is widely used in e-commerce product search to address the shortcomings of lexical matching such as sensitivity to spelling variants. The recent advances in BERT-like language model encoders, have however, not found their way to realtime search due to the strict inference latency requirement imposed on e-commerce websites. While bi-encoder BERT architectures enable fast approximate nearest neighbor search, training them effectively on query-product data remains a challenge due to training instabilities and the persistent generalization gap with cross-encoders. In this work, we propose a four-stage training procedure to leverage large BERT-like models for product search while preserving low inference latency. We introduce query-product interaction pre-finetuning to effectively pretrain BERT bi-encoders for matching and improve generalization. Through offline experiments on an e-commerce product dataset, we show that a distilled small BERT-based model (75M params) trained using our approach improves the search relevance metric by up to 23% over a baseline DSSM-based model with similar inference latency. The small model only suffers a 3% drop in relevance metric compared to the 20x larger teacher. We also show using online A/B tests at scale, that our approach improves over the production model in exact and substitute products retrieved.
The ID93 Tuberculosis Vaccine Candidate Does Not Induce Sensitivity to Purified Protein Derivative (2014)

The tuberculin skin test (TST) is a simple and inexpensive test to determine whether individuals have been exposed to Mycobacterium tuberculosis. This test is not always reliable, however, in people previously immunized with BCG and/or who have been exposed to environmental mycobacterial species due to a reaction to purified protein derivative (PPD) used in the skin test. An issue with BCG, therefore, is that the resulting sensitization to PPD in some individuals compromises the diagnostic use of the skin test. The ability to induce protective immune responses without sensitizing to the tuberculin skin test will be important properties of next-generation tuberculosis (TB) vaccine candidates. We show here that guinea pigs immunized with the candidate TB vaccine ID93/GLA-SE, currently in clinical trials, do not react to intradermal PPD administration. In contrast, positive DTH responses to both ID93 and components thereof were induced in ID93/GLA-SE-immunized animals, indicating robust but specific cellular responses were present in the immunized animals. Noninterference with the TST is an important factor for consideration in the development of a vaccine against M. tuberculosis.
Electronic Devices and Applications to Track Physical Activity (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Platelet Vesicular Monoamine Transporter 2 Density in the Disruptive Behavior Disorders (2011)

In a former study, we reported decreased platelet vesicular monoamine transporter 2 (VMAT2) density (Bmax) in patients with ADHD. The current study aimed at measuring platelet VMAT2 in the disruptive behavior disorders (DBDs) to assess whether this finding is specific to ADHD or generalizable to the broader DBD concept. The study included 13 patients with DBDs aged 10-12 years and 16 healthy volunteers aged 8-17 years. All participants underwent a thorough clinical evaluation using Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version for diagnosis, the Nisonger Child Behavior Rating Form, the Clinical Global Impressions Scale-Severity version, and the DSM-IV ADHD Scale (DAS). The study group's DAS scores did not differ from those of the control group. There was no significant difference between the patients with DBDs and the control group either in VMAT2 density (Bmax) or affinity (Kd) as measured by high-affinity [(3)H]TBZOH binding. We conclude that the formerly reported decreased platelet VMAT2 Bmax in patients with ADHD may be specific to ADHD and not present in DBDs. Larger-scale replication is needed.
THE INFLAMMATORY REFLEX AND THE BRAIN (2004)

Pavlov, V. A.; Ochani, M.; Gallowitsch, M.; Ochani, K.; Huston, J.; Amella, C. A.; Al-Abed, Y.; Ulloa, L.; Liao, H.; Czura, C. J.; Tracey, K. J. Author Information
Physicochemical Properties of ECS Supports and Pt/ECS Catalysts (2021)

As polymer electrolyte membrane fuel cell technologies see increased use in the transportation and energy sectors, there continues to be a need to produce tunable, high-performance oxygen reduction reaction (ORR) catalysts. This work represents the first detailed investigation of commercially available mesoporous nitrogen-functionalized carbon supports with tunable properties (Engineered Carbon Supports, ECS) and ORR catalysts based on platinum nanoparticles (Pt-NPs) supported on these ECS materials produced by Pajarito Powders, LLC. The ECS materials with tunable concentrations of oxygen and nitrogen functional groups and varied carbon graphitization levels were investigated. First, the physicochemical properties of these Pt/ECS catalysts are presented, alongside their bare, Pt-free ECS analogue carbon support materials as investigated through a combination of characterization techniques. This yields a comprehensive catalog of physicochemical properties, including surface area, the concentration of surface dopants (nitrogen and oxygen), evaluation of graphitic content, morphology, and Pt-NP particle size distribution. Then, the ORR performance of the three different Pt/ECS catalysts in membrane electrode assemblies (MEAs) tested under low-relative-humidity conditions is presented as an example of the performance that can be obtained with these materials. All catalysts demonstrated very promising ORR performance at low relative humidity, achieving current densities between 1.8 and 1.3 A/cm2 at 0.6 V. This work demonstrates that carbon supports with engineered morphologies and compositions achieved through the VariPore synthetic technology developed by Pajarito Powders, LLC are a promising platform to produce supports and catalysts with tunable properties for a variety of applications.
Computation of baseline flow across the mouse cortex using two-photon microscopy and vascular anatomical network modeling (2012)

We demonstrate the feasibility of computing baseline flow in the mouse cortex using vascular anatomical network constructed from two-photon microscopy measurements. The values obtained are in good agreement with values reported in the literature.
Synthesis of TiB<SUB>2</SUB>-TiC-Ti<SUB>3</SUB>SiC<SUB>2</SUB> Composites by Reactive Hot Pressing of B<SUB>4</SUB>C-SiC-Ti Powder Mixtures (2008)

TiB2-TiC-Ti3SiC2 composites were reaction-sintered from B4C-xSiC-(3+2x)Ti (x=0 to 1) powder mixtures using reactive hot pressing, and the phase relation of reaction products and sintering behavior were investigated. The reaction B4C+xSiC+(3+2x)Ti→2TiB2+(1−x)TiC+xTi3SiC2 proceeded fundamentally during hot pressing. Although the reaction demands no production of TiC phase at x=1, TiC phase was formed due to the nonstoichiometry of TiC and Ti3SiC2 phases produced. The hot-pressed composites containing the layered compound Ti3SiC2 had no preferential texture. Both TiB2 and TiC were first produced near 960°C during heating, and then Ti3SiC2 near 1200°C. The product Ti3SiC2 contributed effectively to the densification of the composites above 1450°C.
Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O -Methyltransferase (2018)

A series of 8-hydroxy quinolines were identified as potent inhibitors of catechol O-methyltransferase (COMT) with selectivity for the membrane-bound form of the enzyme. Small substituents at the 7-position of the quinoline were found to increase metabolic stability without sacrificing potency. Compounds with good pharmacokinetics and brain penetration were identified and demonstrated in vivo modulation of dopamine metabolites in the brain. An X-ray cocrystal structure of compound 21 in the S-COMT active site shows chelation of the active site magnesium similar to catechol-based inhibitors. These compounds should prove useful for treatment of many neurological and psychiatric conditions associated with compromised cortical dopamine signaling.
Genetic ablation or pharmacological blockade of dipeptidyl peptidase IV does not impact T cell-dependent immune responses (2009)

These data indicate Selective inhibition of DPP-IV does not impair T dependent immune responses to antigenic challenge.
Multisensor Dynamic Waveform Fusion (2007)

Speech communication is significantly more difficult in severe acoustic background noise environments, especially when low-rate speech coders are used. Non-acoustic sensors, such as radar sensors, vibrometers, and bone-conduction microphones, offer significant potential in these situations. We extend previous work on fixed waveform fusion from multiple sensors to an optimal dynamic waveform fusion algorithm that minimizes both additive noise and signal distortion in the estimated speech signal. We show that a minimum mean squared error (MMSE) waveform matching criterion results in a generalized multichannel Wiener filter, and that this filter will simultaneously perform waveform fusion, noise suppression, and crosschannel noise cancellation. Formal intelligibility and quality testing demonstrate significant improvement from this approach.
How to Measure Everything (2014)

The ideal camera measures wide-field diffraction-limited images of the full focal stack with photon-limited spectral and temporal resolution and infinite dynamic range. Multiscale optics and compressive coding may bring practical cameras close to this limit.
Analysis of 3-D Kinematics Using H-Gait System during Walking on a Lower Body Positive Pressure Treadmill (2021)

Recently, treadmills equipped with a lower-body positive-pressure (LBPP) device have been developed to provide precise body weight support (BWS) during walking. Since lower limbs are covered in a waist-high chamber of an LBPP treadmill, a conventional motion analysis using an optical method is impossible to evaluate gait kinematics on LBPP. We have developed a wearable-sensor-based three-dimensional motion analysis system, H-Gait. The purpose of the present study was to investigate the effects of BWS by a LBPP treadmill on gait kinematics using an H-Gait system. Twenty-five healthy subjects walked at 2.5 km/h on a LBPP treadmill under the following three conditions: (1) 0%BWS, (2) 25%BWS and (3) 50%BWS conditions. Acceleration and angular velocity from seven wearable sensors were used to analyze lower limb kinematics during walking. BWS significantly decreased peak angles of hip adduction, knee adduction and ankle dorsiflexion. In particular, the peak knee adduction angle at the 50%BWS significantly decreased compared to at the 25%BWS (<i>p</i> = 0.012) or 0%BWS (<i>p</i> < 0.001). The present study showed that H-Gait system can detect the changes in gait kinematics in response to BWS by a LBPP treadmill and provided a useful clinical application of the H-Gait system to walking exercises.
Automated transportation transfer detection using GPS enabled smartphones (2012)

Understanding the mobility of a traveller from mobile sensor data is an important area of work in context aware and ubiquitous computing. Given a multimodal GPS trace, we will identify where in the GPS trace the traveller changed transportation modes. For example, where in the GPS trace the traveller alight a bus and boards a train, or where did the client stop running and start walking. Using data mining schemes to understand mobility data, in conjunction with real world observations, we propose an algorithm to identify mobility transfer points automatically. We compared the proposed algorithm against the state of the art that is used in the previously proposed work. Evaluation on real world data collected from GPS enabled mobile phones indicate that the proposed algorithm is accurate, has a good coverage, and a good asymptotic run time complexity.
High strength nanostructured films based on well-preserved β-chitin nanofibrils (2019)

Chitin nanofibrils (ChNF) are interesting high-value constituents for nanomaterials due to the enormous amount of waste from the seafood industry. So far, the reported ChNFs are substantially modified and chemically degraded (shortened) during extraction from the organisms. Here, highly individualized and long native-state β-chitin nanofibrils from Illex argentinus squid pens are prepared. A mild treatment was developed to preserve the molar mass, aspect ratio, degree of acetylation and crystallite structure. The fibrils show a uniform diameter of 2-7 nm, very high aspect ratio (up to 750), high degree of acetylation (DA = 99%), and high molar mass (843 500 dalton). The powder X-ray diffraction analysis showed the preserved crystallite structure after protein removal. These "high quality" ChNFs were used to prepare nanostructured films via vacuum filtration from stable hydrocolloids. The effects of well-preserved "native" fibrils on morphology, and film properties (mechanical and optical), were studied and compared with earlier results based on coarser and shorter, chemically degraded chitin fibrils.