gebhart/patrepeval huggingface dataset:
Thermal Stability of Phosphonic Acid Self-Assembled Monolayers on Alumina Substrates (2020)

Thermal stability of several representative self-assembled monolayers (SAMs) with phosphonic acid (PA) anchoring group on Al₂O₃ substrates was studied by in situ high resolution X-ray photoelectron spectroscopy, complemented by thermogravimetric analysis of the relevant bulk materials and theoretical simulations. The range of thermal stability and the degradation pathways were found to be dependent on the chemical composition of the SAM forming molecules, with backbone-specific “weak links”. Whereas the anchoring groups were hardly affected by annealing up to 773 K (highest temperature applied for most of the samples), temperature-induced breakup of the bond between the backbone and anchoring group or a specific bond within the backbone was observed. The former is the case for nonsubstituted alkyl backbone, which is cleaved at temperatures above 673–773 K (depending on the backbone length), with the subsequent desorption of the released fragments. The latter is the case for the substituted (pentafluorophenoxy) or partly fluorinated alkyl backbone, with the bond cleavage occurring at temperatures above 523 K, either between the substitution and alkyl linker or between the fluorinated and nonfluorinated segments of the backbone. The above results suggest a higher robustness and better thermal stability of PA monolayers as compared to other types of SAMs, such as thiolates on coinage metal substrates. It is however advisible to test thermal stability of a specifically designed, functional PA SAM in context of possible “weak links” as far as this is important for a particular application.
Strong and specific interaction of ultra small superparamagnetic iron oxide nanoparticles and human activated platelets mediated by fucoidan coating (2013)

Activated platelets play a pivotal role in cardiovascular diseases such as atherothrombosis. Therefore, strategies enabling activated platelet molecular imaging are of great interest. Herein, a chemical protocol was investigated for coating superparamagnetic iron oxide nanoparticles with low molecular weight fucoidan, a ligand of P-selectin expressed on the surface of activated platelets. The physico–chemical characterization of the obtained product demonstrated successful fucoidan coating and its potential as a T2 MRI contrast agent. The specificity and the strength of the interaction between fucoidan-coated iron oxide nanoparticles and human activated platelets was demonstrated by flow cytometry. Micromagnetophoresis experiments revealed that platelets experience magnetically-induced motion in the presence of a magnetic field gradient created by a micromagnet. Altogether, these results indicate that superparamagnetic iron oxide nanoparticles coated with low molecular weight fucoidan may represent a promising molecular imaging tool for activated platelets in human diseases.
Usefulness of monitoring congestive heart failure by multiple impedance vectors (2008)

All impedance vectors decreased during CHF. Impedance measurement employing left heart sensors correlated well wit- - h LA pressure, and may improve detection of CHF onset compared to sensing by RA or RV leads alone. This approach has important clinical implications for managing heart failure patients in the ambulatory setting.
Model-based Approach to Multi-domain Monitoring Data Aggregation (2021)

The essential propellant for any closed-loop management mechanism is data related to the managed entity. While this is a general evidence, it becomes even more true when dealing with advanced closed-loop systems like the ones supported by Artificial Intelligence (AI), as they require a trustworthy, up-to-date and steady flow of state data to be applicable. Modern network infrastructures provide a vast amount of disparate data sources, especially in the multi-domain scenarios considered by the ETSI Industry Specification Group (ISG) Zero Touch Network and Service Management (ZSM) framework, and proper mechanisms for data aggregation, pre-processing and normalization are required to make possible AI-enabled closed-loop management. So far, solutions proposed for these data aggregation tasks have been specific to concrete data sources and consumers, following ad-hoc approaches unsuitable to address the vast heterogeneity of data sources and potential data consumers. This paper presents a model-based approach to a data aggregator framework, relying on standardized data models and telemetry protocols, and integrated with an open-source network orchestration stack to support their incorporation within network service lifecycles.
A Maxwell's fish eye lens for the terahertz region (2013)

We implement a two-dimensional Maxwell's fish eye lens using a waveguide-based artificial dielectric. The Maxwell's fish eye lens consists of two metallic cylindrical plates sandwiching a free-space region, with the inner surface of one plate shaped into a hollow conical form. This lens has the capability to image terahertz beams from a source located at the edge (between the plates) to the diametrically opposite point on the edge, independent of the incident angle.
Abstract A205: Targeting caspase-9/PP2A interaction as a new antitumor strategy. (2011)

Abstract Background: Dysfunction in the regulation of apoptosis is associated with important pathologies, including cancers. While apoptosis is known to rely on the Bcl-2 family members and caspases, recent data suggest that the serine/threonine phosphatase PP2A is a key actor in regulating both Bcl-2 family members and caspases for cell life or cell death decision. Cell penetrating peptides are molecules that can translocate into cells without causing membrane damage, leading to their proposed use as vector for delivering therapeutic cargo. Focusing on both caspase-9 and PP2A, our goal was to develop cell penetrating peptides specifically designed against the caspase-9/PP2A interaction and evaluate their in vitro and in vivo therapeutic potential in various cancer cells and tumors. Materials and Methods: We have published the Drug Phosphatase Technology (DPT) based on the design of cell penetrating peptides obtained by association of a cell permeable shuttle, DPT-sh1 to a sequence of interest. We have also shown a direct interaction of human caspase-9/human PP2Ac, detected by co-immunoprecipitation and confirmed by far western. We decided to generate a peptide containing the previously published penetrating sequence (DPT-Sh1) associated to the site of interaction of human caspase-9 (DPT-C9h), in order to disturb the interaction caspase-9/PP2Ac. Using both mouse and human breast (BC) and non-small cell lung (NSCLC) cancer cells and tumors, we have then investigated the effect of DPT-C9 (specific to the sequence of the mouse caspase-9) and DPT-C9h (specific to the sequence of the human caspase-9) peptides. In in vivo experiments, DPT-C9 and DPT-C9h peptides were intraperitonealy administered at doses ranging from 1 to 50 mg/kg/day for up to 6 weeks. Results: We have demonstrated that both DPT-C9 and DPT-C9h peptides specifically blocked in vitro, in vivo, and ex vivo caspase-9/PP2A interaction, and induced caspase-9 activation and apoptosis in all tested cancer cell lines. In in vivo experiments, we have showed that DPT-C9 induced significant tumor growth inhibition (TGI) in mice bearing transgenic Polyoma Middle-T PymT mouse breast tumors and in mice bearing Kras mutated mouse NSCLC tumors. Similarly, DPT-C9h induced significant TGI in various primary human BC and NSCLC xenografts. Finally, no toxicity has been observed in treated mice, as well as no immunogenic response in immunodeficient mice. Conclusions: We have identified an interaction between caspase-9/PP2A that may be used as a new therapeutic target. Using the cell penetrating peptide DPT-C9h blocking this interaction, we have demonstrated that DPT-C9h had an impressive in vitro and in vivo therapeutic effect and therefore constitutes a new therapeutic approach of human cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr A205.
Increase of SARS-CoV 3CL peptidase activity due to macromolecular crowding effects in the milieu composition (2010)

The 3C-like peptidase of the severe acute respiratory syndrome virus (SARS-CoV) is strictly required for viral replication, thus being a potential target for the development of antiviral agents. In contrast to monomeric picornavirus 3C peptidases, SARS-CoV 3CLpro exists in equilibrium between the monomer and dimer forms in solution, and only the dimer is proteolytically active in dilute buffer solutions. In this study, the increase of SARS-CoV 3CLpro peptidase activity in presence of kosmotropic salts and crowding agents is described. The activation followed the Hofmeister series of anions, with two orders of magnitude enhancement in the presence of Na₂SO₄, whereas the crowding agents polyethylene glycol and bovine serum albumin increased the hydrolytic rate up to 3 times. Kinetic determinations of the monomer dimer dissociation constant (K(d)) indicated that activation was a result of a more active dimer, without significant changes in K(d) values. The activation was found to be independent of substrate length and was derived from both k(cat) increase and K(m) decrease. The viral peptidase activation described here could be related to the crowded intracellular environment and indicates a further fine-tuning mechanism for biological control, particularly in the microenvironment of the vesicles that are induced in host cells during positive strand RNA virus infection.
Data from Molecular Subtypes of Breast Cancers Detected in Mammography Screening and Outside of Screening (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; The frequency and significance of gene expression profile-derived molecular subtypes of breast cancers found in mammography screening are unknown.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We identified breast cancers diagnosed in women of any age living in defined geographic regions in Finland in 1991 to 1992 and collected clinical and pathologic data. Surrogates for the molecular subtypes were determined for 247 cancers found in organized mammography screening and 989 cancers detected outside of screening using immunohistochemistry or &lt;i&gt;in situ&lt;/i&gt; hybridization. Molecular subtypes were defined as luminal A [estrogen receptor (ER) positive and/or progesterone receptor (PR) positive, &lt;i&gt;HER2&lt;/i&gt;-], luminal B (ER+ and/or PR+, &lt;i&gt;HER2&lt;/i&gt;+), basal-like (ER-, PR-, &lt;i&gt;HER2&lt;/i&gt;-, cytokeratin 5+, and/or HER1+), &lt;i&gt;HER2&lt;/i&gt;+/ER- (ER-, PR-, and &lt;i&gt;HER2&lt;/i&gt;+), and unclassified. The median follow-up time was 9.4 years.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; The luminal type A was common (73.7%) and the &lt;i&gt;HER2&lt;/i&gt;+/ER- type is rare (5.7%) in screen-detected cancer, and only 16% were &lt;i&gt;HER2&lt;/i&gt; positive. Women with cancer diagnosed in screening at ages 50 to 69 years had similar molecular subtype distribution as women whose cancer was found outside of screening at age &gt;69 years. In a multivariate model, cancer detection at screening independently predicted favorable distant disease-free survival when the molecular subtype was included as a covariate in addition to age, histologic grade, and cancer size. Women with small (pT&lt;sub&gt;1&lt;/sub&gt;N&lt;sub&gt;0&lt;/sub&gt;M&lt;sub&gt;0&lt;/sub&gt;) &lt;i&gt;HER2&lt;/i&gt;-positive cancer had similar outcome regardless of the method of detection.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Molecular subtype distribution of screen-detected breast cancer differs from that of cancers found outside of screening and accounts in part for the better outcome of screen-detected cancer.&lt;/p&gt;&lt;/div&gt;
The Strategy of Agricultural Export in India's Economic Development (1964)

The broad objectives of this paper are: (a) to reflect the nature of relationships between agricultural export and India's planned developemtn; (b) to identify the trand in India's agricultural exports in relation to the world commodity markets; and (c) to suggest the areas of study in order to work as a guideline for steps to be taken to promote the future export markets.
Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events (2006)

Macropinocytosis, a form of bulk uptake of fluid and solid cargo into cytoplasmic vacuoles, called macropinosomes, has been studied mostly in relation to antigen presentation. Early membrane traffic events occurring in this process are, however, largely unknown. Using human dendritic cells we show that a marked increase in the rate of macropinocytosis occurs a few minutes after application of two markers (small latex beads or dextran), depends on a slow intracellular Ca2+ concentration ([Ca2+](i)) rise that precedes the PI3K-dependent step, and is preceded and accompanied by exocytosis of enlargeosomes compensating in part for the macropinocytic plasma membrane internalization. Unexpectedly, macropinosomes themselves, which share markers with endosomes, undergo Ca2+ -dependent exocytosis so that, after approximately 20 minutes of continuous bead or dextran uptake, an equilibrium is reached preventing cells from overloading themselves with the organelles. Large [Ca2+](i) increases induced by ionomycin trigger rapid (<1 minute) exocytic regurgitation of all macropinosomes, whereas endosomes remain apparently unaffected. We conclude that, in dendritic cells, the rate of macropinocytosis is not constant but increases in a regulated fashion, as previously shown in other cell types. Moreover, macropinosomes are not simple containers that funnel cargo to an endocytic pathway, but unique organelles, distinct from endosomes by their competence for regulated exocytosis and other membrane properties.
Cationic amphitropic gemini surfactants with hydrophilic oligo(oxyethylene) spacer chains (1998)

New gemini diammonium surfactants have been synthesized in which the spacer chain consists of oligo(oxyethylene) units and which exhibit thermotropic liquid crystalline lamellar α and β as well as lyotropic mesophases.
A low power superconductor-to-optoelectronic interface (2019)

We present a ultrahigh-impedance superconducting thermal switch that acts as a superconductor-to-optoelectronic interface. We demonstrated the generation of photons in a cryogenic photonic LED from a low-voltage input, detecting those photons with a waveguide-coupled detector.
Biomechanics of Brain and Spinal-Cord Injury: Analysis of Neuropathologic and Neurophysiology Experiments (1999)

Abstract This study analyzes 46 brain and 48 spinal-cord impact experiments. The velocity of brain impact was 2.0-10.0 m/s and displacement, 0.75-5.0 mm (5.3-33% compression) using a controlled pneumatic impact. The velocity of spinal-cord impact was 1.5-6.0 m/s and displacement, 1.25-3.25 mm (25-65% compression). Brain injury varied from cortical contusion, diffuse axonal injury (DAI), to fatalities, and spinal-cord injury from temporary to complete loss of somatosensory-evoked potentials. Logist functions were determined for each injury severity and various biomechanical parameters, VC, C, V, and combinations. Brain and spinal-cord injury is most strongly correlated to VC, the viscous response. The goodness-of-fit was x2 = 22.1, R-0.84 and p< 0.0000 for fatal brain injury, x2 = 27.5, R = 0.96 and p< 0.0000 for cortical contusion, and x2 = 17.7, R = 0.49 and p < 0.0001 for partial recovery of spinal-cord conduction. Neural tissue is viscoelastic, with a rate-dependent tolerance related to energy absorption. VC is a measure of energy absorption by impact deformation and is predictive of neural contusion, DAI, long-duration coma, spinal-cord dysfunction, and death. Tolerances for various severities of neural injury are presented. At the tissue level, VC is the product of strain and strain-rate, ε dε/dt. The research shows that strain is not a sufficient parameter of neural injury risk, and that the product of strain and strain-rate is a key biomechanical parameter for brain and spinal-cord injury.
ChemInform Abstract: Enzymic Catalysis in Organic Media (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Gα q/11 pathway (2002)

MrgA1 and MrgC11 belong to a recently identified family of orphan G-protein coupled receptors, called mrgs (mas-related genes). They are only expressed in a specific subset of sensory neurons that are known to detect painful stimuli. However, the precise physiological function of Mrg receptors and their underlying mechanisms of signal transduction are not known. We therefore have screened a series of neuropeptides against human embryonic kidney (HEK) 293 cells that stably express either MrgA1 or MrgC11 to identify ligands and/or agonists. MrgA1- or MrgC11-specific agonists stimulated dose-dependent increases in intracellular free Ca(2+) in a pertussis toxin-insensitive manner, but failed to alter basal or forskolin-stimulated levels of intracellular cAMP. Furthermore, studies using embryonic fibroblasts derived from various Galpha protein knockout mice demonstrated that both the MrgA1 and MrgC11 receptors are coupled to the Galpha(q/11) signaling pathway. Screening of neuropeptides identified surrogate agonists, most of these peptides included a common C-terminal -RF(Y)G or -RF(Y) amide motif. Structure-function studies suggest that endogenous ligands of Mrg receptors are likely to be RF(Y)G and/or RF(Y) amide-related peptides and that postprocessing of these peptides may serve to determine Mrg receptor-ligand specificity. The differences in ligand specificity also suggest functional diversity amongst the Mrg receptors.
Design and use of a system-level specification and verification methodology (1995)

This paper describes the problem of Design Capture at System level and of moving a design verifiably down levels of abstraction. We describe our steps on the way to designing a methodology which captures system level interface and functional specifications, and enables the designers to decompose and refine specifications down to RTL VHDL in a hierarchic and piece-wise manner.
Clicking and Squeaking: In Vivo Correlation of Sound and Separation for Different Bearing Surfaces (2008)

Glaser, Diana Dipl-Ing, PhD; Komistek, Richard D. PhD; Cates, Harold E. MD; Mahfouz, Mohamed R. PhD Author Information
Coalescing: Syntactic Abstraction for Reasoning in First-Order Modal Logics (2014)

We present a syntactic abstraction method to reason about first-order modal logics by using theorem provers for standard first-order logic and for propositional modal logic.
Advanced high power-density interior permanent magnet motor for traction applications (2013)

Electric drive systems, which include electric machines and power electronics, are a key enabling technology for advanced vehicle propulsion systems that reduce the petroleum dependence of the ground transportation sector. To have significant effect, electric drive technologies must be economical in terms of cost, weight, and size while meeting performance and reliability expectations. This paper will provide details of the design, analysis and testing of an advanced interior permanent magnet (IPM) machine that was developed to meet the FreedomCar 2020 specifications. The 12 slot/10 pole machine has segmented stator structure equipped with fractional-slot concentrated-windings (FSCW). The rotor has a novel spoke structure. Several prototypes with different thermal management schemes have been built and tested. The paper will cover the test results for all these prototypes and highlight the tradeoffs between the various schemes.
Integration of optical devices and nanotechnology for conducting genome research (2011)

SPR based sensing techniques utilize a spectroscopy for transducing biomolecular binding events to variations in spectra. This label-free and real-time technique has widely applied for conducting biomedical research. In this study, we present a spectroscopy-based SPR system for monitoring binding between human serum albumin and nucleic acid library. Compared with conventional SPR technique, this novel system utilizes cost-effective nanostructured arrays and a portable UV-Vis spectrometer. These advantages enable a promising development of a portable analytical device for widespread applications. Meanwhile, multispectral analysis used here also helps increase the sensitivity, and thus transducing the binding event to optical signal efficiently. The result demonstrates that this cost-effective and portable system could be applied for a future application of selecting target aptamer. Moreover, we also present surface enhanced Raman spectroscopy (SERS) on the nanostructured arrays in a label-free approach. This integration of multiple spectroscopy technologies is utilized for conducting genome research efficiently.
Integration by shadow mask process of ZnO:Ga sputtered layers onto microsensor platform for detection of sub-ppm acetaldehyde concentration (2017)

International audience
In Vivo Quantification of Human Coronary Artery Deformation From Cardiac-Gated Computed Tomography Data (2009)

Despite significant advances in percutaneous coronary interventions (PCI), bifurcation lesions still remain technically challenging for treatment. In an attempt to treat bifurcation lesions, innovative interventional techniques such as T-stenting, V-stenting and crush stenting have been developed. However, stenting both main and branch vessels inherently involves geometrical constraint on the devices at the site of a branch junction. Moreover, dynamic cardiac motion may cause significant deformation of the coronary artery (Fig. 1) and hence may adversely impact the functionality as well as durability of stents. This critical issue has been emphasized by recent studies on stent strut fracture-induced restenosis in a bifurcation lesion [1]. Although it has been hypothesized that cardiac motion causes significant mechanical stress on coronary stents, three-dimensional (3D) characteristics of the coronary artery deformation are not well understood. The purpose of this study was to quantify the change in the bifurcation angle between the left anterior descending coronary artery (LAD) and left circumflex artery (LCX), and the curvature change of the LAD during the cardiac cycle.