gebhart/patrepeval huggingface dataset:
Far IR Emission and Thermal Properties of Ceramics Coated Fabrics by IR Thermography (2006)

The purpose of this study was to develop the warm-up suit that is comfortable as well as has good thermal performance. The function of warm-up suit is to keep the body warm and thus to lose it’s weight by sweating. Ceramic powders, such as zirconium and magnesium oxide have been incorporated into the textile structures to utilize the far infrared radiation effect of ceramics, which heat substrates homogeneously by activating molecular motion. Thermal manikin tests were conducted to determine the clothing insulation and evaporative resistance of the selected warm-up suits. Also, the far IR emission effects of ceramics containing laminate on the body heat transfer were evaluated with the thermogram data using IR camera. The results showed that the ceramics inside laminate slightly increased the thermal insulation and the evaporative resistance. Thermogram showed that when the fabric was heated with the thermal manikin, surface mean temperatures of fabrics were increased as the ceramic incorporated, and the heat storage performance was confirmed.
WWOX in biological control and tumorigenesis (2007)

The WW domain-containing oxidoreductase (WWOX) gene is located at 16q23.1-16q23.2, a region that spans the second most common human fragile site, FRA16D. The WWOX protein contains two N-terminal WW domains and a central short chain oxidoreductase-like domain. In the last few years, considerable amount of data have shown inactivation of WWOX in a variety of human malignancies. Moreover, interacting partners have been identified biochemically that define, at least in part, the molecular mechanism of WWOX action. Recently, we demonstrated that targeted deletion of the Wwox gene in the mouse led to increased incidence of spontaneous and chemically induced tumor formation, thereby providing the first in vivo evidence that WWOX is a bona fide tumor suppressor. This review focuses on the most recent progress in understanding WWOX function as a tumor suppressor.
Quantum Resistant Authentication Algorithms for Satellite-Based Augmentation Systems (2018)

Cryptography in the form of digital signatures can be a part of the solution to the threat of spoofing and is going to be implemented on Galileo and other Global Navigation Satellite Systems (GNSS). Digital signatures incorporated into the data stream authenticate the integrity of the data as well as the origin of the message. A multitude of signature algorithms already exist. Most are designed for use over the internet where there are fast data rates, high computing power and the option for call and response. Implementing a digital signature on a system such as a Satellite-Based Augmentation System (SBAS) for use in aviation will require the signature to be short, one-way and secure for the next 30 or more years. With the advent of quantum computing, many state-of-the-art authentication schemes are no longer viable, so an authentication scheme implemented in SBAS will need to be quantum secure. This paper introduces the cryptographic primitives (foundational problems) necessary to understand the vulnerabilities in modern day cryptography due to quantum computing and investigates the use of TESLA (Timed Efficient Stream Loss-Tolerant Authentication) and EC-Schnorr algorithms in broadcast systems. A brief introduction to quantum computing and how it will change the field of cryptography is presented followed by attacks on the aforementioned authentication schemes. State of the art quantum resistant authentication algorithms are introduced and compared with the earlier classical cryptographic methods. Finally, recommendations are put forward for the selection and implementation of authentication schemes for SBAS that withstand the threat of quantum computing.
Supplementary Figure 3 from Anticancer Activity of a Novel Selective CYP17A1 Inhibitor in Preclinical Models of Castrate-Resistant Prostate Cancer (2023)

&lt;p&gt;Supplementary Figure 3: Supplementary results on SRBEP-1 and HMGCR transcripts.&lt;/p&gt;
Transverse-Mode Analysis of Red-Emitting Highly Polarized Vertical-Cavity Surface-Emitting Lasers (2011)

We present experimental investigations of the transverse beam profile and polarization characteristics of GaInP-based oxide-confined vertical-cavity surface-emitting lasers in dependence on the oxide aperture size, mesa size, current, and temperature. We demonstrate that these lasers with aperture diameters of less than <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$6$</tex></formula> <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\mu$</tex></formula> m are required for stable fundamental-mode operation. The influence of operation current and external temperature on the mode shape is investigated. We experimentally present a highly stable linearly polarized GaInP-based microcavity laser emitting at around <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$655$</tex></formula> nm, where the polarization characteristics originate from intrinsic material properties.
Steady-state microwave mode cooling with a diamond NV ensemble (2022)

A fundamental result of quantum mechanics is that the fluctuations of a bosonic field are given by its temperature $T$. An electromagnetic mode with frequency $ω$ in the microwave band has a significant thermal photon occupation at room temperature according to the Bose-Einstein distribution $\bar{n} = k_BT / \hbarω$. The room temperature thermal state of a 3 GHz mode, for example, is characterized by a mean photon number $\bar{n} \sim 2000$ and variance $Δn^2 \approx \bar{n}^2$. This thermal variance sets the measurement noise floor in applications ranging from wireless communications to positioning, navigation, and timing to magnetic resonance imaging. We overcome this barrier in continuously cooling a ${\sim} 3$ GHz cavity mode by coupling it to an ensemble of optically spin-polarized nitrogen-vacancy (NV) centers in a room-temperature diamond. The NV spins are pumped into a low entropy state via a green laser and act as a heat sink to the microwave mode through their collective interaction with microwave photons. Using a simple detection circuit we report a peak noise reduction of $-2.3 \pm 0.1 \, \textrm{dB}$ and minimum cavity mode temperature of $150 \pm 5 \textrm{K}$. We present also a linearized model to identify the important features of the cooling, and demonstrate its validity through magnetically tuned, spectrally resolved measurements. The realization of efficient mode cooling at ambient temperature opens the door to applications in precision measurement and communication, with the potential to scale towards fundamental quantum limits.
More Comments on IV Filter Debate (1988)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Electrostatic Contributions to Colchicine Binding within Tubulin Isotypes (2009)

Tubulin, the structural subunit of microtubules, is the target of some highly successful anti-tumor drugs. Most of these drugs bind to the beta-tubulin resulting in the inhibition of microtubule dynamics and eventually cell death. The varied cellular distribution of several human isotypes of beta -tubulin provides a platform upon which to construct novel chemotherapeutic agents that are able to differentiate between these types of cells. To test this hypothesis, we have previously created homology models of the nine most frequently observed human beta -tubulin isotypes and analyzed them for differences in the colchicine-binding site. Here, we describe the electrostatic properties of the colchicine binding site and how this may affect calculated drug binding affinities between the beta -tubulin isotypes.
Constrained Smoothers for State Estimation of Vapor Compression Cycles (2022)

State estimators can be a powerful tool in the development of advanced controls and performance monitoring capabilities for vapor compression cycles, but the nonlinear and numerically stiff aspects of these systems pose challenges for the practical implementation of estimators on large physics-based models. We develop smoothing methods in the extended and ensemble Kalman estimation frameworks that satisfy physical constraints and address practical limitations with standard implementations of these estimators. These methods are tested on a model built in the Julia language, and are demonstrated to successfully estimate unmeasured variables with high accuracy.
Effects of Gamma Radiation on Various Polyimides (2000)

Abstract Four polyimides (PIa‐PId) containing 4,4′‐hexafluoroisopropylidene‐bisphthalic anhydride (6FDA) units in the backbone were prepared via one‐step synthesis. The effects of different doses of gamma radiation from a cobalt‐60 source are studied. The irradiated and the unirradiated polyimides are characterized by using tensile strength, infrared (IR), viscosity, differential scanning calorimeter (DSC), and gel permeation chromatography (GPC). All polyimides show the increase of tensile strength and elongation at low doses (&gt;350 Mrad). The molecule weights decrease as the irradiation doses increase. All samples showed a drastic degradation of the mechanical and thermal properties at doses above 1400 Mrad. Samples irradiated at a dose of 2800 Mrad were completely brittle. The major difference of the radiation effect of the polyimides depends largely on their structural differences. PId with an extra hexafluoroisopropylidene moiety is most sensitive to irradiation at high doses.
ChemInform Abstract: The Olefin Metathesis Reaction: Applications in the Pharmaceutical Industry (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Visualization of Conductive Spinal Cord Activity Using a Biomagnetometer (2002)

The authors concluded that magnetic field measurement is useful for evaluation of spinal cord function. Moreover, it was apparent that SCEFs could indicate conduction block in the spinal cord.
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip (2021)

Many patients infected with coronaviruses, such as SARS-CoV-2 and NL63 that use ACE2 receptors to infect cells, exhibit gastrointestinal symptoms and viral proteins are found in the human gastrointestinal tract, yet little is known about the inflammatory and pathological effects of coronavirus infection on the human intestine. Here, we used a human intestine-on-a-chip (Intestine Chip) microfluidic culture device lined by patient organoid-derived intestinal epithelium interfaced with human vascular endothelium to study host cellular and inflammatory responses to infection with NL63 coronavirus. These organoid-derived intestinal epithelial cells dramatically increased their ACE2 protein levels when cultured under flow in the presence of peristalsis-like mechanical deformations in the Intestine Chips compared to when cultured statically as organoids or in Transwell inserts. Infection of the intestinal epithelium with NL63 on-chip led to inflammation of the endothelium as demonstrated by loss of barrier function, increased cytokine production, and recruitment of circulating peripheral blood mononuclear cells (PBMCs). Treatment of NL63 infected chips with the approved protease inhibitor drug, nafamostat, inhibited viral entry and resulted in a reduction in both viral load and cytokine secretion, whereas remdesivir, one of the few drugs approved for COVID19 patients, was not found to be effective and it also was toxic to the endothelium. This model of intestinal infection was also used to test the effects of other drugs that have been proposed for potential repurposing against SARS-CoV-2. Taken together, these data suggest that the human Intestine Chip might be useful as a human preclinical model for studying coronavirus related pathology as well as for testing of potential anti-viral or anti-inflammatory therapeutics.
Supporting Heterogeneous Applications in the DECOS Integrated Architecture (2006)

The DECOS integrated time-triggered architecture provides a framework for integrating multiple heterogeneous real-time application subsystems within a single distributed computer system while retaining the fault-isolation, fault-containment and complexity-management benefits of a classic federated system. A central issue in the DECOS architecture is the provision of standardized, validated and certified services that facilitate the development of distributed real-time applications. This paper describes how these services are structured within the architecture in order to satisfy the diverse requirements of heterogeneous applications (e.g. different real-time requirements, different criticality levels). In particular we focus on the reuse of legacy subsystems, and show the feasibility of our concept by implementing a Controller Area Network (CAN) application within the integrated architecture. 1
Early outcomes of a modern cemented total knee arthroplasty (2021)

This is the largest series to date of this design of implant. At short-term follow-up, the rate of aseptic tibial loosening is not overly concerning. Further observation is required to determine if there will be an abnormal rate of loosening at mid- to long-term follow-up. Cite this article: <i>Bone Joint J</i> 2021;103-B(6 Supple A):51-58.
Use of Galactosylated-Streptavidin as a Clearing Agent with 111 In-Labeled, Biotinylated Antibodies to Enhance Tumor/Non-Tumor Localization Ratios (2002)

Optimal tumor imaging using radiolabeled antibodies (Abs) depends on obtaining the highest possible tumor/non-tumor localization ratios. To increase this ratio, in a mouse xenograft model system, we induced rapid blood clearance of the Ab after extensive penetration of a solid tumor, at 24 hr after Ab injection. By using galactosylated streptavidin (gal-SA) as a clearing agent for biotinylated Abs, and by using an 111In-DTPA (diethylenetriaminepentaacetic acid) label, clearance was directed to hepatocytes (as opposed to Kupffer cells), and the radiolabel was excreted by the hepatocytes into bile, thereby reducing accumulation in the liver. In this study, we directly compared this approach with the use of 99mTc-F(ab)2 fragments, using the same Ab to carcinoembryonic antigen (CEA), with a colon carcinoma xenograft. The gal-SA clearance method produced substantially higher tumor/non-tumor localization ratios for all tissues except the liver, and even for the liver the disadvantage of the gal-SA clearance method was small. We also tested the gal-SA clearance method with a xenograft model of human B-cell lymphoma, using anti-CD22. High tumor/non-tumor ratios were obtained, as previously described with carcinomas of the lung and colon. Therefore, this approach appears to be a generally applicable strategy to obtain relatively high tumor/non-tumor ratios.
Influence of processing on PVC structure property relationships (1992)

Abstract The influence of the rheology of extruded PVC on the developed morphology and properties was explored. Extrusion conditions for PVC siding formulations with CPE impact modifiers have been investigated on a lab scale twin screw extruder using a factorial model in the experimental design. The independent variables were the barrel temperatures, the die temperature, the hopper feed rate, and the screw rpms. The dependent variables examined include the torque, melt temperature, output rate, fusion level, morphology, and impact resistance. The correlations of the dependent variables with the independent variables were evaluated with the statistical analysis package SAS TM . The correlations among several of the dependent variables were also evaluated.
Proteomic Analysis of Neisseria gonorrhoeae Biofilms Shows Shift to Anaerobic Respiration and Changes in Nutrient Transport and Outermembrane Proteins (2012)

Neisseria gonorrhoeae, the causative agent of gonorrhea, can form biofilms in vitro and in vivo. In biofilms, the organism is more resistant to antibiotic treatment and can serve as a reservoir for chronic infection. We have used stable isotope labeling by amino acids in cell culture (SILAC) to compare protein expression in biofilm and planktonic organisms. Two parallel populations of N. gonorrhoeae strain 1291, which is an arginine auxotroph, were grown for 48 h in continuous-flow chambers over glass, one supplemented with (13)C(6)-arginine for planktonic organisms and the other with unlabeled arginine for biofilm growth. The biofilm and planktonic cells were harvested and lysed separately, and fractionated into three sequential protein extracts. Corresponding heavy (H) planktonic and light (L) biofilm protein extracts were mixed and separated by 1D SDS-PAGE gels, and samples were extensively analyzed by liquid chromatography-mass spectrometry. Overall, 757 proteins were identified, and 152 unique proteins met a 1.5-fold cutoff threshold for differential expression with p-values <0.05. Comparing biofilm to planktonic organisms, this set included 73 upregulated and 54 downregulated proteins. Nearly a third of the upregulated proteins were involved in energy metabolism, with cell envelope proteins making up the next largest group. Of the downregulated proteins, the largest groups were involved in protein synthesis and energy metabolism. These proteomics results were compared with our previously reported results from transcriptional profiling of gonococcal biofilms using microarrays. Nitrite reductase and cytochrome c peroxidase, key enzymes required for anaerobic growth, were detected as highly upregulated in both the proteomic and transcriptomic datasets. These and other protein expression changes observed in the present study were consistent with a shift to anaerobic respiration in gonococcal biofilms, although changes in membrane proteins not explicitly related to this shift may have other functions.
Improved performance of traveling wave directional coupler modulator based on electro-optic polymer (2012)

Polymer based electro-optic modulators have shown great potentials in high frequency analog optical links. Existing commercial LiNibO3 Mach-Zehnder modulators have intrinsic drawbacks in linearity to provide high fidelity communication. In this paper, we present the design, fabrication and characterization of a traveling wave directional coupler modulator based on electro-optic polymer, which is able to provide high linearity, high speed, and low optical insertion loss. A silver ground electrode is used to reduce waveguide sidewall roughness due to the scattering of UV light in photolithography process in addition to suppressing the RF loss. A 1x2 multi-mode interference 3dB-splitter, a photobleached refractive index taper and a quasi-vertical taper are used to reduce the optical insertion loss of the device. The symmetric waveguide structure of the MMI-fed directional coupler is intrinsically bias-free, and the modulation is obtained at the 3-dB point regardless of the ambient temperature. By achieving low RF loss, characteristic impedance matching with 50&Omega; load, and excellent velocity matching between the RF wave and the optical wave, a travelling wave electrode is designed to function up to 62.5GHz. Domain-inversion poling with push-pull configuration is applied using alternating pulses on a 2-section directional-coupler to achieve a spurious free dynamic range of 110dB/Hz<sup>2/3</sup>. The 3-dB electrical bandwidth of device is measured to be 10GHz.
Hodgkin Lymphoma—Review on Pathogenesis, Diagnosis, Current and Future Treatment Approaches for Adult Patients (2021)

Hodgkin lymphoma (HL) is a rare malignancy accounting for roughly 15% of all lymphomas and mostly affecting young patients. A second peak is seen in patients above 60 years of age. The history of HL treatment represents a remarkable success story in which HL has turned from an incurable disease to a neoplasm with an excellent prognosis. First-line treatment with stage-adapted treatment consisting of chemotherapy and/or radiotherapy results in cure rates of approximately 80%. Second-line treatment mostly consists of intensive salvage chemotherapy followed by high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT). Novel approaches such as antibody drug conjugates and immunomodulatory drugs have shown impressive results in clinical trials in refractory and relapsed HL and are now increasingly implemented in earlier treatment lines. This review gives a comprehensive overview on HL addressing epidemiology, pathophysiology and current treatment options as well as recent developments and perspectives.
Novel Methodology for Enzymatic Removal of Atrazine from Water by CBD-Fusion Protein Immobilized on Cellulose (2000)

s-Triazines including atrazine are heavily used agricultural herbicides, and their extensive removal from industrial wastewater is required before these effluents can be disposed. The use of enzymes for this purpose is an important potential alternative to conventional methods of detoxification. The purpose of the present study was to develop an enzyme-based technology for the treatment of atrazine contaminated water. In this paper we describe the construction and expression of two fusion proteins which dechlorinate atrazine while being firmly bound to an insoluble cellulose matrix. Dechlorination of atrazine produces in one enzymatic step the nonregulated compound hydroxyatrazine from the regulated mother compound, atrazine.
Substrate-Controlled Group-Selective Radical Cyclizations. A New Strategy for Stereocontrolled Transformations of Diastereomeric Reactive Intermediates (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstrate-Controlled Group-Selective Radical Cyclizations. A New Strategy for Stereocontrolled Transformations of Diastereomeric Reactive IntermediatesDennis P. Curran, Hongyan Qi, Nicholas C. DeMello, and Chien-Hsing LinCite this: J. Am. Chem. Soc. 1994, 116, 18, 8430–8431Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/ja00097a086https://doi.org/10.1021/ja00097a086research-articleACS PublicationsRequest reuse permissionsArticle Views300Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts