gebhart/patrepeval huggingface dataset:
Assessing Reservoir Connectivity through Biomarker and Bulk Compositional Gradient Analysis (2010)

Abstract Reservoir connectivity is among the most important risk factors in deepwater environments and cannot always be identified by traditional techniques such as pressure surveys, petrophysical logs, and geochemical fingerprints. Here we describe a workflow in which reservoir connectivity is assessed through a combination of traditional techniques, compositional gradient analysis, and geochemical evalution of reservoir history. That workflow is demonstrated in a case study in which compositional gradients are detected by optical spectroscopy (which provides a precise measurement of asphaltene content) and viscosity measurements. These gradients are interpreted in the context of the modified Yen model, which characterizes different aggregatation states of asphaltenes and can be used to predict the magnitude of asphaltene content gradients in condensates, black oils, and heavy oils. Additionally, fluid composition is studied with two sophisticated laboratory techniques: comprehensive twodimensional gas chromatography, which measures the detailed composition of the nonpolar fraction of petroleum, and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry, which measures the detailed composition of the polar fraction of petroleum. These complentary techniques provide a detailed picture of the composition of almost the entire crude oil, enabling confident biomarker identification and analysis. In this case study, a series of 25-norhopanes and mildly altered normal and isoprenoid alkanes were detected, suggesting the reservoir has experienced multiple charges and contains a mixture of oils biodegraded to different extents. Compositional gradients and interpreted reservoir history are consistent with a connected reservoir in which the observed viscosity variation originates from gravitational segregation of asphaltene nanoaggregates in a crude oil with high asphaltene concentration resulting from a biodegraded charge. This combination of traditional techniques, analysis of compositional gradients delineated by optical spectroscopy, and sophisticated laboratory measurements allows connectivity to be assessed with greater confidence than otherwise attainable during exploration and appraisal.
3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17 (2018)

The orphan receptor GPR17 may be a novel drug target for inflammatory diseases. 3-(2-Carboxyethyl)-4,6-dichloro-1 H-indole-2-carboxylic acid (MDL29,951, 1) was previously identified as a moderately potent GPR17 agonist. In the present study, we investigated the structure-activity relationships (SARs) of 1. Substitution of the indole 1-, 5-, or 7-position was detrimental. Only small substituents were tolerated in the 4-position while the 6-position accommodated large lipophilic residues. Among the most potent compounds were 3-(2-carboxyethyl)-1 H-indole-2-carboxylic acid derivatives containing the following substituents: 6-phenoxy (26, PSB-1737, EC<sub>50</sub> 270 nM), 4-fluoro-6-bromo (33, PSB-18422, EC<sub>50</sub> 27.9 nM), 4-fluoro-6-iodo (35, PSB-18484, EC<sub>50</sub> 32.1 nM), and 4-chloro-6-hexyloxy (43, PSB-1767, EC<sub>50</sub> 67.0 nM). (3-(2-Carboxyethyl)-6-hexyloxy-1 H-indole-2-carboxylic acid (39, PSB-17183, EC<sub>50</sub> 115 nM) behaved as a partial agonist. Selected potent compounds tested at human P2Y receptor subtypes showed high selectivity for GPR17. Docking into a homology model of the human GPR17 and molecular dynamic simulation studies rationalized the observed SARs.
Author response for "Low beta repetitive transcranial magnetic stimulation to human dorsolateral prefrontal cortex during object recognition memory sample presentation, at a task related frequency observed in local field potentials in homologous macaque cortex, impairs subsequent recollection but not familiarity" (2021)

Low-beta repetitive transcranial magnetic stimulation to human dorsolateral prefrontal cortex during object recognition memory sample presentation, at a task-related frequency observed in local field potentials in homologous macaque cortex, impairs subsequent recollection but not familiarity
Supplementary Figures 1 - 5 from NY-ESO-1 Expression in Meningioma Suggests a Rationale for New Immunotherapeutic Approaches (2023)

&lt;p&gt;PDF file - 849K, Supplementary Figure 1 - Expression of Cancer/Testis Genes in Meningioma. Supplementary Figure 2 - NY-ESO-1 and MAGEA3 Expression in Testis. Supplementary Figure 3 - MAGEA3 Expression in Meningioma. Supplementary Figure 4 - Immunohistochemistry of Human Lymphocytes in Tonsil. Supplementary Figure 5 - Correlation of NY-ESO-1 expression and patient outcome.&lt;/p&gt;
Baking temperature dependence of Cu paste on A1-BSF cell properties (2017)

We investigated the baking temperature dependence of Al-BSF cell properties using Cu paste metallization and a metal oxide (MO) layer. The baking conditions of Cu paste were changed to find an optimum condition to achieve good adhesion, diffusion barrier property, and low contact resistance. Using 2 cm square cells, the conversion efficiency of 17.80% could be obtained, which was equivalent to the property of commercial Ag paste cells cut into the same size.
ESC II - ESC With Active Steering Intervention (2004)

&lt;div class="htmlview paragraph"&gt;Through the decline in prices of semiconductor technology, automotive applications have boosted and can be characterized in technological leaps, the first example was the introduction of ABS in 1978 leading on to the equipment with ESC in 1995.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;In the next technological leap forward, the cross-linking of today's many and varied, largely stand-alone chassis control units, is envisaged. This technological leap forward in networking, the functional integration of brakes and steering, is described by the ESC II system.&lt;/div&gt;
Tocotrienol levels in adipose tissue of benign and malignant breast lumps in patients in Malaysia. (2007)

Data on dietary exposure to vitamin E by plasma or adipose tissue concentrations of alpha-tocopherol (alpha-T) in observational studies have failed to provide consistent support for the idea that alpha-T provides women with any protection from breast cancer. In contrast, studies indicate that alpha, gamma, and delta-tocotrienols but not alpha-T have potent anti-proliferative effects in human breast cancer cells. Our aim was to investigate whether there was a difference in tocopherol and tocotrienol concentrations in malignant and benign adipose tissue, in a Malaysian population consuming predominantly a palm oil diet. The study was undertaken using fatty acid levels in breast adipose tissue as a biomarker of qualitative dietary intake of fatty acids. The major fatty acids in breast adipose tissue of patients (benign and malignant) were oleic acid (45-46%), palmitic (28-29%) and linoleic (11-12%). No differences were evident in the fatty acid composition of the two groups. There was a significant difference (p=0.006) in the total tocotrienol levels between malignant (13.7 +/- 6.0 microg/g) and benign (20+/-6.0 microg/g) adipose tissue samples. However, no significant differences were seen in the total tocopherol levels (p=0.42) in the two groups. The study reveals that dietary intake influences adipose tissue fatty acid levels and that adipose tissue is a dynamic reservoir of fat soluble nutrients. The higher adipose tissue concentrations of tocotrienols in benign patients provide support for the idea that tocotrienols may provide protection against breast cancer.
Experimental Confirmation of a Predicted Porous Hydrogen‐Bonded Organic Framework (2023)

Abstract Hydrogen‐bonded organic frameworks (HOFs) with low densities and high porosities are rare and challenging to design because most molecules have a strong energetic preference for close packing. Crystal structure prediction (CSP) can rank the crystal packings available to an organic molecule based on their relative lattice energies. This has become a powerful tool for the a priori design of porous molecular crystals. Previously, we combined CSP with structure‐property predictions to generate energy‐structure‐function (ESF) maps for a series of triptycene‐based molecules with quinoxaline groups. From these ESF maps, triptycene trisquinoxalinedione (TH5) was predicted to form a previously unknown low‐energy HOF (TH5‐A) with a remarkably low density of 0.374 g cm −3 and three‐dimensional (3D) pores. Here, we demonstrate the reliability of those ESF maps by discovering this TH5‐A polymorph experimentally. This material has a high accessible surface area of 3,284 m 2 g −1 , as measured by nitrogen adsorption, making it one of the most porous HOFs reported to date.
Capabilities of the remainders of nominal Kendrick masses and the referenced Kendrick mass defects for copolymer ions (2017)

Fig. S1. ‘Double RNKME–RNKMVA’ plot from the KMD-RNKM plots of an EVA sample computed with E and VA as the base units (KMD, Kendrick mass defect; RNKM, remainder of nominal Kendrick mass). No direct correlation is found between RNKMs and DPs, and the plot is not informative (DP, degree of polymerization). Fig. S2. E-based KMD plots from the MALDI mass spectra of two EVA samples at (A) 40 wt% and (B) 25 wt%. (C, D) DP plots computed with E and VA as the base units and (H, H, Na) as the reference. The variation in the composition in E and VA units is directly highlighted by the change in DPs. Fig. S3. Resolution-enhanced KMD plots from the MALDI mass spectrum of a P(EO-b-PO-b-EO) sample computed with (A) EO/43 and (B) PO/57 fractional base units. High-resolution plots are isotopically and oligomerically resolved. Fig. S4. (A) Aliased KMD plot from the MALDI mass spectrum of an EVA sample computed with VA as the base unit. (B) Aliased DP plot with E and VA as the base units and (H, H, Na) as the reference. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Synthesis and Spectroscopic Characterization of Octaacetic Acid Tetraphenylporphyrins (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Spectroscopic Characterization of Octaacetic Acid TetraphenylporphyrinsMichiko Miura, Sabir A. Majumder, J. David Hobbs, Mark W. Renner, Lars R. Furenlid, and John A. ShelnuttCite this: Inorg. Chem. 1994, 33, 26, 6078–6085Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/ic00104a016https://doi.org/10.1021/ic00104a016research-articleACS PublicationsRequest reuse permissionsArticle Views152Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Characteristics of laser produced plasmas and lasers for pulsed ion sources (1996)

Preliminary experiments were performed to investigate the fundamental characteristics of the laser produced plasmas and the KrF lasers for the pulsed ion beam production. (1) Lithium target was irradiated by a small e‐beam pumped KrF laser and the exhausted plasmas were measured. (2) A larger KrF laser of the same kind was operated and the output characteristics were observed. (3) The mode patterns of a discharge‐pumped KrF laser was also measured most recently to prepare the future target irradiation to produce ion‐source plasmas.
An Efficient Visual Hull Computation Algorithm (2002)

In this paper we describe an efficient algorithm for computing the visual hull of an object. This problem is equivalent to computing the intersection of generalized cones. The nave visual hull computation algorithm requires intersecting 3D polyhedra. We exploit the special structure of generalized cone polyhedra and show how to reduce this computation to a set of intersections in 2D. Moreover, we describe how the 2D intersections can be carried out efficiently.
Reproducibility of the Retinal Vascular Response to Flicker Light in Asians (2009)

Measurements of the dilation response of retinal vessels to diffuse luminance flicker an Asian sample using the DVA show high reproducibility for repeated measures over a short period of time. Such measurements may allow non-invasive quantification of endothelial function to study its association with systemic and ocular diseases.
Glycyrrhiza glabra-Enhanced Extract and Adriamycin Antiproliferative Effect on PC-3 Prostate Cancer Cells (2019)

Prostate cancer is the second most commonly diagnosed cancer in men worldwide, which is almost incurable, once it progresses into the metastatic stage. Adriamycin (ADR) is a known chemotherapeutic agent that causes severe side effects. In recent years, studies in natural plant products have revealed their anticancer activities. In particular, <i>Glycyrrhiza glabra</i> enhanced extract (GGE), commonly known as licorice, has been reported to exert antiproliferative properties against cancer cells. In this study, the cytotoxic potential of GGE was assessed in PC-3 cells, when it is administrated alone or in combination with Adriamycin. PC-3 cells were treated with GGE and/or ADR, and the inhibition of cell proliferation was evaluated by the MTT assay. Cell cycle alterations and apoptosis rate were measured through flow cytometry. Expression levels of autophagy-related genes were evaluated with specific ELISA kits, Western blotting, and real-time PCR, while NMR spectrometry was used to identify the implication of specific metabolites. Our results demonstrated that GGE alone or in co-treatment with ADR shows antiproliferative properties against PC-3 cells, which are mediated by both apoptosis and autophagy mechanisms.
Optimal Fundamental Load Modulation for Class-X Harmonically Tuned Power Amplifier (2019)

This paper presents a mathematical model of the optimal fundamental load modulation design space for Class-X harmonically tuned power amplifiers (PAs). Starting from Class-X PA with maximally flat waveform, the optimal fundamental load trajectory that maintains constant high efficiency for different output power back-off level is obtained. Optimal fundamental load trajectory with different sets of second and third harmonic impedances are studied and verified with harmonic load-pull measurement. By carefully choosing the second and third harmonic load impedance, the optimal fundamental load trajectory can cross the real axis, which provides more flexibility in amplifier design. A 10W Cree GaN transistor, CG2H40010F, is measured at 800 MHz. The measured load-pull contours locate on the calculated optimal fundamental trajectory which validates the theory proposed in this work.
Application of Comparative Phylogenomics To Study the Evolution ofYersinia enterocoliticaand To Identify Genetic Differences Relating to Pathogenicity (2006)

Yersinia enterocolitica, an important cause of human gastroenteritis generally caused by the consumption of livestock, has traditionally been categorized into three groups with respect to pathogenicity, i.e., nonpathogenic (biotype 1A), low pathogenicity (biotypes 2 to 5), and highly pathogenic (biotype 1B). However, genetic differences that explain variation in pathogenesis and whether different biotypes are associated with specific nonhuman hosts are largely unknown. In this study, we applied comparative phylogenomics (whole-genome comparisons of microbes with DNA microarrays combined with Bayesian phylogenies) to investigate a diverse collection of 94 strains of Y. enterocolitica consisting of 35 human, 35 pig, 15 sheep, and 9 cattle isolates from nonpathogenic, low-pathogenicity, and highly pathogenic biotypes. Analysis confirmed three distinct statistically supported clusters composed of a nonpathogenic clade, a low-pathogenicity clade, and a highly pathogenic clade. Genetic differences revealed 125 predicted coding sequences (CDSs) present in all highly pathogenic strains but absent from the other clades. These included several previously uncharacterized CDSs that may encode novel virulence determinants including a hemolysin, a metalloprotease, and a type III secretion effector protein. Additionally, 27 CDSs were identified which were present in all 47 low-pathogenicity strains and Y. enterocolitica 8081 but absent from all nonpathogenic 1A isolates. Analysis of the core gene set for Y. enterocolitica revealed that 20.8% of the genes were shared by all of the strains, confirming this species as highly heterogeneous, adding to the case for the existence of three subspecies of Y. enterocolitica. Further analysis revealed that Y. enterocolitica does not cluster according to source (host).
Homeostasis and transitional activation of regulatory T cells require c-Myc (2020)

Regulatory T cell (T<sub>reg</sub>) activation and expansion occur during neonatal life and inflammation to establish immunosuppression, yet the mechanisms governing these events are incompletely understood. We report that the transcriptional regulator c-Myc (Myc) controls immune homeostasis through regulation of T<sub>reg</sub> accumulation and functional activation. Myc activity is enriched in T<sub>regs</sub> generated during neonatal life and responding to inflammation. Myc-deficient T<sub>regs</sub> show defects in accumulation and ability to transition to an activated state. Consequently, loss of Myc in T<sub>regs</sub> results in an early-onset autoimmune disorder accompanied by uncontrolled effector CD4<sup>+</sup> and CD8<sup>+</sup> T cell responses. Mechanistically, Myc regulates mitochondrial oxidative metabolism but is dispensable for fatty acid oxidation (FAO). Indeed, T<sub>reg</sub>-specific deletion of Cox10, which promotes oxidative phosphorylation, but not Cpt1a, the rate-limiting enzyme for FAO, results in impaired T<sub>reg</sub> function and maturation. Thus, Myc coordinates T<sub>reg</sub> accumulation, transitional activation, and metabolic programming to orchestrate immune homeostasis.
Constellation Expansion for 100G Transmission (2013)

In this letter, we focus on coherently detected, non differentially encoded, polarisation division multiplexed 100G communication systems; through incorporating phase noise in the channel model, we assess the net coding gain achievable by various constellations that can be used in lieu of the conventional quadrature phase-shift keying (QPSK). Whereas the optical community put much effort into the optimization of the forward error correction codes for QPSK, trying to reduce the gap to the Shannon limit, we show that a potential gain of more than 2 dB is still available if different constellations are adopted.
Repression of a Potassium Channel by Nuclear Hormone Receptor and TGF-β Signaling Modulates Insulin Signaling in Caenorhabditis elegans (2012)

Transforming growth factor β (TGF-β) signaling acts through Smad proteins to play fundamental roles in cell proliferation, differentiation, apoptosis, and metabolism. The Receptor associated Smads (R-Smads) interact with DNA and other nuclear proteins to regulate target gene transcription. Here, we demonstrate that the Caenorhabditis elegans R-Smad DAF-8 partners with the nuclear hormone receptor NHR-69, a C. elegans ortholog of mammalian hepatocyte nuclear factor 4α HNF4α), to repress the exp-2 potassium channel gene and increase insulin secretion. We find that NHR-69 associates with DAF-8 both in vivo and in vitro. Functionally, daf-8 nhr-69 double mutants show defects in neuropeptide secretion and phenotypes consistent with reduced insulin signaling such as increased expression of the sod-3 and gst-10 genes and a longer life span. Expression of the exp-2 gene, encoding a voltage-gated potassium channel, is synergistically increased in daf-8 nhr-69 mutants compared to single mutants and wild-type worms. In turn, exp-2 acts selectively in the ASI neurons to repress the secretion of the insulin-like peptide DAF-28. Importantly, exp-2 mutation shortens the long life span of daf-8 nhr-69 double mutants, demonstrating that exp-2 is required downstream of DAF-8 and NHR-69. Finally, animals over-expressing NHR-69 specifically in DAF-28-secreting ASI neurons exhibit a lethargic, hypoglycemic phenotype that is rescued by exogenous glucose. We propose a model whereby DAF-8/R-Smad and NHR-69 negatively regulate the transcription of exp-2 to promote neuronal DAF-28 secretion, thus demonstrating a physiological crosstalk between TGF-β and HNF4α-like signaling in C. elegans. NHR-69 and DAF-8 dependent regulation of exp-2 and DAF-28 also provides a novel molecular mechanism that contributes to the previously recognized link between insulin and TGF-β signaling in C. elegans.
Protein dynamics from chemical-shift and dipolar-rotational spin-echo nitrogen-15 NMR (1989)

The partial collapse of dipolar and chemical shift tensors for peptide NH and for the amide NH at cross-link sites in cell wall peptidoglycan, of intact lyophilized cells of Aerococcus viridans, indicates NH vector root-mean-square fluctuations of 23 degrees. This result is consistent with the local mobility calculated in typical picosecond regime computer simulations of protein dynamics in the solid state. The experimental root-mean-square angular fluctuations for both types of NH vectors increase to 37 degrees for viable wet cells at 10 degrees C. The similarity in mobilities for both general protein and cell wall peptidoglycan suggests that one additional motion in wet cells involves cooperative fluctuations of segments of cell walls, attached proteins, and associated cytoplasmic proteins.
Booting process technology for wavelength initialization in WDM-PON OLT and ONT (2012)

We propose a booting process related to a wavelength initialization of light source of optical line terminal (OLT) and optical network terminal (ONT) in wavelength division multiplexing passive optical network (WDM-PON). A stable operation of wavelength initialization is observed for OLT and ONT optical transceiver. The proposed process use minimized optical devices such as filter and photo diode (PD) for wavelength initialization.
Adjusting the disparity of stereoscopic 3D media in post production (2013)

Selecting the convergence point and interaxial distance before the production of stereoscopic 3D media presents several challenges. There are few tools for previsualizing or validating model calculations, so estimating these parameters to match an intended shot relies on costly experience, intuition and iteration. Poor selection of these parameters can also cause or amplify viewer discomfort [Mendiburu 2009]. Figure 1 illustrates the relationship between discomfort and disparity (input images by Scharstein and Pal [2007]).