gebhart/patrepeval huggingface dataset:
Concurrent Inflammatory Bowel Disease and Myelodysplastic Syndromes (1999)

Myelodysplastic syndromes (MDS) may be associated with inflammatory bowel disease (IBD). We characterized the clinical features and outcomes of patients with concurrent IBD and MDS. Using a diagnostic index, we identified all patients with both IBD and MDS at our center between 1976 and 1997. We also calculated an incidence rate of MDS in IBD using population-based data from Olmsted County, Minnesota, between 1950 and 1993. Among approximately 15,000 IBD patients seen, 25 (approximately 0.17%) were diagnosed with MDS. Fourteen had Crohn's disease and 11 had ulcerative colitis. The median age at diagnosis of IBD, particularly Crohn's disease, was higher than expected. Median age at diagnosis of MDS was typical. All but one ulcerative colitis patient was diagnosed before the diagnosis of MDS, while one-half of Crohn's disease patients were diagnosed with both ailments simultaneously. Five patients who had been diagnosed with IBD first were persistently anemic for at least 1 year prior to diagnosis of MDS. Two Crohn's disease patients had received purine analogs in the past. Median follow-up after MDS diagnosis was 1 year. Seven patients died, including two who progressed to acute myeloid leukemia. The incidence rate of MDS in IBD based on Olmsted County data was 0 cases per 100,000 person-years (95% CI, 0-55.2). The seemingly high frequency of myelodysplastic syndromes in a large referral-based group of patients with IBD suggests an association; however, an increased risk of MDS was not observed in a small regional cohort of IBD patients. Patients with MDS are diagnosed with concurrent IBD at an age older than expected. Simultaneous diagnoses were made in one-half of Crohn's disease patients. MDS should be considered in the differential diagnosis of anemia in IBD patients.
Noise-dependent postfiltering (2004)

The paper introduces a modification of the commonly used postfilter that improves performance when acoustic background noise is present. The modification consists of replacing the nonadaptive postfilter parameters that govern the degree of spectral emphasis (commonly denoted as /spl gamma//sub 1/ and /spl gamma//sub 2/) with parameters that adapt to the noise statistics. We describe an effective mapping from the noise statistics to the emphasis parameters and provide a low complexity noise estimation algorithm that is sufficient for this application. The resulting noise-adaptive postfilter successfully attenuates the background noise and naturally converges to the conventional postfilter at high SNR conditions. Thus, the speech enhancement problem is solved with minimal modification of legacy codecs, since the existing structure of the speech codec is used. Test results indicate that the presented algorithm significantly outperforms the standard postfilter with non-adaptive parameters.
WCDMA HSDPA Network Performance with Receive Diversity and LMMSE Chip Equalization (2006)

More advanced receiver structures than the conventional single antenna Rake can be used to improve the signal-to-noise (SNR) ratios, which is especially beneficial in order to utilize the high bit rates provided by the HSDPA concept in WCDMA network. In WCDMA system, orthogonal Walsh-Hadamard sequences are used as channelization codes. In frequency-selective fading channels the orthogonality of channelization codes disappears and intra-cell multiple access interference (MAI) arises. In order to mitigate the effect of MAI, a chip-level equalization has shown to be a simple and effective solution. The effectiveness of chip equalization, however, degrades at the cell borders where the inter-cell interference dominates rather than MAI. Dual antenna is a straight-forward solution to mitigate that performance drop. In this paper we consider receivers equipped with dual antenna and linear minimum mean squared error (LMMSE) chip-level equalizers and present an analysts of the expected gains over conventional single and dual antenna rake receivers in realistic situations by using a dynamic WCDMA system-level tool
Data from Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;High-grade serous ovarian cancer (HGSOC) is often sensitive to initial treatment with platinum and taxane combination chemotherapy, but most patients relapse with chemotherapy-resistant disease. To systematically identify genes modulating chemotherapy response, we performed pooled functional genomic screens in HGSOC cell lines treated with cisplatin, paclitaxel, or cisplatin plus paclitaxel. Genes in the intrinsic pathway of apoptosis were among the top candidate resistance genes in both gain-of-function and loss-of-function screens. In an open reading frame overexpression screen, followed by a mini-pool secondary screen, anti-apoptotic genes including &lt;i&gt;BCL2L1&lt;/i&gt; (BCL-XL) and &lt;i&gt;BCL2L2&lt;/i&gt; (BCL-W) were associated with chemotherapy resistance. In a CRISPR-Cas9 knockout screen, loss of &lt;i&gt;BCL2L1&lt;/i&gt; decreased cell survival whereas loss of proapoptotic genes promoted resistance. To dissect the role of individual anti-apoptotic proteins in HGSOC chemotherapy response, we evaluated overexpression or inhibition of BCL-2, BCL-XL, BCL-W, and MCL1 in HGSOC cell lines. Overexpression of anti-apoptotic proteins decreased apoptosis and modestly increased cell viability upon cisplatin or paclitaxel treatment. Conversely, specific inhibitors of BCL-XL, MCL1, or BCL-XL/BCL-2, but not BCL-2 alone, enhanced cell death when combined with cisplatin or paclitaxel. Anti-apoptotic protein inhibitors also sensitized HGSOC cells to the poly (ADP-ribose) polymerase inhibitor olaparib. These unbiased screens highlight anti-apoptotic proteins as mediators of chemotherapy resistance in HGSOC, and support inhibition of BCL-XL and MCL1, alone or combined with chemotherapy or targeted agents, in treatment of primary and recurrent HGSOC.&lt;/p&gt;Implications:&lt;p&gt;Anti-apoptotic proteins modulate drug resistance in ovarian cancer, and inhibitors of BCL-XL or MCL1 promote cell death in combination with chemotherapy.&lt;/p&gt;&lt;/div&gt;
A Comprehensive Review of Enhancements and Prospects of Fast Handovers for Mobile IPv6 Protocol (2018)

The emerging mobility management schemes for the fifth generation (5G) of mobile networks mostly follow the network-based protocol principles, which do not involve the mobile node (MN) in their operation. Such solutions have not been able to meet the ultra-low handover latency requirement in complex mobility scenarios in 5G. These objectives can be potentially achieved through increased involvement of MN in the handover operation, which can now be conveniently effectuated through virtualization technologies. In this regard, the classical host-based Fast Handovers for Mobile IPv6 (FMIPv6) protocol has the potential to offer several benefits due to its distinctive features, such as link-layer assistance for handover preparation, in-advance new care-of address formulation, and buffering services. Several enhancements to the FMIPv6 protocol have also been proposed, which improve its handover performance. Many of these enhancements focus on the baseline FMIPv6 specification, while others aim to enhance its operation by adding support features, such as mobile multicast, vertical handovers, quality of service assurance, as well as security support. Moreover, several enhancements to the access-technology-specific solutions for FMIPv6 have also been proposed. This paper aims to provide a systematic review of FMIPv6 enhancements in order to gain insight into its advantages as well as its shortcomings. Based on the review, this paper also discusses the evolution prospects of FMIPv6 toward 5G. Finally, some of its potential limitations along with possible research directions in the context of 5G are also indicated.
Tetrabutylammonium Salt Induced Denitration of Nitropyridines:  Synthesis of Fluoro-, Hydroxy-, and Methoxypyridines (2005)

An efficient method for the synthesis of fluoropyridines via the fluorodenitration reaction is reported. The reaction is mediated by tetrabutylammonium fluoride (TBAF) under mild conditions without undue regard to the presence of water. The fluorodenitration is general for 2- or 4-nitro-substituted pyridines, while 3-nitropyridines require attendant electron-withdrawing groups for the reaction to proceed efficiently. Nitropyridines also undergo hydroxy- and methoxydenitration under mild conditions in the presence of the corresponding tetrabutylammonium species. [reaction: see text]
High definition 3D ultrasound imaging. (1997)

We have demonstrated high definition and improved resolution using a novel scanning system integrated with a commercial ultrasound machine. The result is a volumetric 3D ultrasound data set that can be visualized using standard techniques. Unlike other 3D ultrasound images, image quality is improved from standard 2D data. Image definition and bandwidth is improved using patent pending techniques. The system can be used to image patients or wounded soldiers for general imaging of anatomy such as abdominal organs, extremities, and the neck. Although the risks associated with x-ray carcinogenesis are relatively low at diagnostic dose levels, concerns remain for individuals in high risk categories. In addition, cost and portability of CT and MRI machines can be prohibitive. In comparison, ultrasound can provide portable, low-cost, non-ionizing imaging. Previous clinical trials comparing ultrasound to CT were used to demonstrate qualitative and quantitative improvements of ultrasound using the Sandia technologies. Transverse leg images demonstrated much higher clarity and lower noise than is seen in traditional ultrasound images. An x-ray CT scan was provided of the same cross-section for comparison. The results of our most recent trials demonstrate the advantages of 3D ultrasound and motion compensation compared with 2D ultrasound. Metal objects can also be observed within the anatomy.
Development of Knowledge CAE system for Analysis support (2002)

A CAE system utilizing knowledge and know-how for the support of analytic works has been developed. The present system has two key features. One is the easy and brief system construction in response to several analytic works. The other is guidance of analysis procedure and supports using analysis knowledge. Using the present system, designers can carry out analytic works which have been traditionally done by experts for CAE.
Deposition of a-Si:H/a-SiC:H multilayer film by excimer laser CVD. (1989)

The deposition of a-Si: H/a-SiC: H multilayer film by ArF excimer laser chemical vapor deposition has been demonstrated. Each layer thickness was determined from a reactant gas pressure and a laser irradiation time. The XPS spectrum of the multilayer films shows that the chemical component of each layer changes periodically with an Ar ion etching time and X-ray diffraction intensity of the films shows that the period is in good agreement with the value calculated from the deposition rate. The optical measurement of the films shows that the optical bandgap of the multilayer films increased with decreasing a-Si: H layer thickness. The result can be interpreted in terms of the electron quantum confinement effect in the band structure of an amorphous semiconductor.
Tailoring Lewis/Brønsted acid properties of MOF nodes via hydrothermal and solvothermal synthesis: simple approach with exceptional catalytic implications (2021)

The Lewis/Brønsted catalytic properties of the Metal-Organic Framework (MOF) nodes can be tuned by simply controlling the solvent employed in the synthetic procedure. In this work, we demonstrate that Hf-MOF-808 can be prepared from a material with a higher amount of Brønsted acid sites, <i>via</i> modulated hydrothermal synthesis, to a material with a higher proportion of unsaturated Hf Lewis acid sites, <i>via</i> modulated solvothermal synthesis. The Lewis/Brønsted acid properties of the resultant metallic clusters have been studied by different characterization techniques, including XAS, FTIR and NMR spectroscopies, combined with a DFT study. The different nature of the Hf-MOF-808 materials allows their application as selective catalysts in different target reactions requiring Lewis, Brønsted or Lewis-Brønsted acid pairs.
Screening for Pancreatic Adenocarcinoma Using Signals From Web Search Logs: Feasibility Study and Results (2016)

Signals in search logs show the possibilities of predicting a forthcoming diagnosis of pancreatic adenocarcinoma from combinations of subtle temporal signals revealed in the queries of searchers.
High‐Performance, High‐Index‐Contrast Chalcogenide Glass Photonics on Silicon and Unconventional Non‐planar Substrates (2014)

This paper reports a versatile technique for the fabrication of high‐index‐contrast photonic structures on both silicon and plastic substrates. The fabrication technique combines low‐temperature chalcogenide glass film deposition and resist‐free single‐step thermal nanoimprint to process low‐loss, sub‐micron single‐mode waveguides with a smooth surface finish using simple contact photolithography. Using this approach, the first chalcogenide glass microring resonators are fabricated by thermal nanoimprinting. The devices exhibit an ultra‐high quality factor of 4 × 10 5 near 1550 nm wavelengths, which represents the highest value reported in chalcogenide glass microring resonators. Furthermore, sub‐micrometer nanoimprinting of chalcogenide glass films on non‐planar plastic substrates is demonstrated, which establishes the method as a facile route for the monolithic fabrication of high‐index‐contrast devices on a wide array of unconventional substrates.
Use of magnetic resonance elastography to gauge meningioma intratumoral consistency and histotype (2022)

The results of this prospective study provide substantial evidence that preoperative evaluation of meningiomas with MRE can reliably characterize tumor stiffness and spatial heterogeneity to aid neurosurgical planning.
Designing interactive music mixing applications for mobile devices (2007)

Mobile devices are a potential platform for interactive music mixing applications for a large target audience. In this paper, the authors discuss the development of four such application concepts. The concepts were implemented as software prototypes for PDAs and mobile phones. The authors reflect on the design decisions and the technical obstacles they encountered. Solutions related to the user interfaces and creating content for interactive music mixing applications are also discussed.
The Physical Insight into Holding Voltage Engineering of SCR for ESD Protection (2022)

In this work, the holding voltage characteristics of Silicon-Controlled-Rectifier (SCR) with different cathode structures are studied and compared. The cathode structures include the different W/L ratios and the gap between the P+ and N+ diffusion layers (pocket implants) in the cathode Pwell region. These devices show tunable high holding voltage and improved failure current (It2), which strongly depends on the W/L ratio of P+ and N+ diffusion layers. The uniform carrier current distribution in the cathode allows tuning holding voltage with W/L > 1 without affecting the other TLP characteristics like breakdown voltage, trigger voltage, depth of snap back, and holding current. With a higher W/L ratio> 1, the failure current can be improved significantly by 30%. Hence, this work provides physical insights into the holding voltage and failure current engineering in high holding voltage (HHV) SCRs, which offers a robust design for Electrostatic Discharge (ESD) protection.
Electron spin resonance spectroscopy of the triplet state of m-xylylene (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron spin resonance spectroscopy of the triplet state of m-xylyleneBradford B. Wright and Matthew S. PlatzCite this: J. Am. Chem. Soc. 1983, 105, 3, 628–630Publication Date (Print):February 1, 1983Publication History Published online1 May 2002Published inissue 1 February 1983https://pubs.acs.org/doi/10.1021/ja00341a057https://doi.org/10.1021/ja00341a057research-articleACS PublicationsRequest reuse permissionsArticle Views381Altmetric-Citations81LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Induction of protective T cell immunity against influenza using a novel peptide vaccine (2012)

Influenza infection remains an important cause of global morbidity despite current vaccine strategies which generate antibody responses to surface viral proteins. Recent studies have established that naturally occurring T cells which recognise highly conserved core viral proteins and limit illness against a range of viral strains.We aimed to demonstrate that induction of T cell memory using a novel peptide vaccine (Flu-V) could limit influenza severity using a human viral challenge model. 32 seronegative healthy males were randomised to receive 500μg of peptide vaccine or placebo. All subjects were challenged by nasal instillation of live A/Wisconsin/67/2005 (H3N2). Safety, tolerability, influenza severity and cellular immunity data were collected. The vaccine was safe and well tolerated. No pre-existing T cell responses to the novel Flu-V vaccine were seen at baseline by IFN-y release assay. All subjects in the treatment arm demonstrated strong induction of the peptide specific cellular response (fold rise 8.2± 3.9 (Range 2.0-30.6) p=0.0005). The strength of the induction of T cell response to Flu-V inversely correlated with influenza illness severity -symptoms r=-0.786, p=0.02 and viral shedding r=-0.821, p=0.01. Furthermore the peptide vaccine induced strong cellular responses against heterologous strains including H1N1pdm in vitro. Peptide vaccination can induce cellular immunity to influenza which correlates closely with disease protection in humans. T cell responses can be induced against a range of strains and therefore this approach carries potential for the induction of broad heterologous immunity required to protect against future pandemics.
Monolithic integration of InGaAs-InAlGaAs optoelectronic devices for 1.55µm emission by quantum well intermixing (1998)

A novel quantum well intermixing (QWI) technique 1 has been used to achieve substantial band gap shifts in the InGaAs-InAlGaAs material system enabling the first demonstration of monolithically integrated devices in this system. Wavelength tuned lasers have also been fabricated, displaying a tuning range up to 150 nm.
<title>Passive millimeter-wave imaging: seeing in very poor visibility</title> (1995)

It is more common to use the visible or infrared regions to image although it is possible to use millimeter waves. Passive millimeter wave imaging, however, has the advantage of being able to see in poor weather conditions such as in thick fog. The images, unlike radar signatures, have a natural appearance that can be easily interpreted. The spatial resolution of these imagers is limited by the aperture size and choice of operating frequency. Novel signal processing algorithms have been applied to improve the spatial resolution. Millimeter wave imagers detect slight temperature differences in the scene and using current technology it is possible to sense changes as low as 0.2 K whilst the contrast between an aircraft and its background can be as high as 200 K. A millimetric imager has been used at London Heathrow airport to demonstrate the high quality of the images that can be obtained. Aircraft can be recognized, runways and grass delineated and complex areas such as gates imaged. A qualitative comparison has been made of radar, thermal imaging and passive millimeter wave imaging for ground movement control. The possibility of deploying a passive millimeter wave imager on a commercial aircraft and of using it as part of an enhanced vision system is also discussed.
Reproducibility of the First Image of a Black Hole in the Galaxy M87 from the Event Horizon Telescope (EHT) Collaboration (2022)

This paper presents an interdisciplinary effort aiming to develop and share sustainable knowledge necessary to analyze, understand, and use published scientific results to advance reproducibility in multi-messenger astrophysics. Specifically, we target the breakthrough work associated with the generation of the first image of a black hole, called M87. The image was computed by the Event Horizon Telescope Collaboration. Based on the artifacts made available by EHT, we deliver documentation, code, and a computational environment to reproduce the first image of a black hole. Our deliverables support new discovery in multi-messenger astrophysics by providing all the necessary tools for generalizing methods and findings from the EHT use case. Challenges encountered during the reproducibility of EHT results are reported. The result of our effort is an open-source, containerized software package that enables the public to reproduce the first image of a black hole in the galaxy M87.
Magnetism in heterogeneous thin film systems: Resonant x-ray scattering \nstudies (2002)

Magnetic and chemical heterogeneity are common in a broad range of magnetic thin film systems. Emerging resonant soft x-ray scattering techniques are well suited to resolve such heterogeneity at relevant length scales. Resonant x-ray magneto-optical Kerr effect measurements laterally average over heterogeneity but can provide depth resolution in different ways, as illustrated in measurements resolving reversible and irreversible changes in different layers of exchange-spring heterostructures. Resonant small-angle scattering measures in-plane heterogeneity and can resolve magnetic and chemical scattering sources in different ways, as illustrated in measurements of granular alloy recording media.
MM cell lines have PCNA in their cytosol. (2015)

&lt;p&gt;(A) Confocal fluorescence images of immunofluorescently stained PCNA (green) in JJN-3, RPMI-8226 cells and three new in-house made MM cell lines (KJON, VOLIN, and URVIN). DRAQ5 was used for nuclear staining (blue) of KJON, VOLIN, and URVIN. HeLa cells were used as control for low levels of PCNA staining in the cytosol (fluorescence image of PCNA and transmitted light image). Bar, 5 µm. (B) Western blot analysis of caspase 3 cleavage (Input, upper panel) and co-immunoprecipitation of procaspase 3 using α-PCNA beads (IP PCNA, lower panel) from JJN-3 cells after overnight treatment with 6 and 10 µM ATX-101 alone or in combination with 1 µM melphalan. The bar graphs show the quantification from the blot above. Cleaved caspase 3 in the input samples (upper panel) was corrected for loading differences (β-actin) and normalized to procaspase 3. (C) Western blot analysis of caspase 3 and caspase 8 cleavage in RPMI-8226 cells after 4 h treatment with 6 and 10 µM ATX-101 alone or in combination with 2 µM melphalan. The bar graphs show the quantification of cleaved caspase 3 normalized to procaspase 3 after correction for loading differences (β-actin) (upper graph) and cleaved caspase 8 normalized to β-actin (lower graph). (B and C) show results from representative experiments out of at least three.&lt;/p&gt;