gebhart/patrepeval huggingface dataset:
A keratin biomaterial gel hemostat derived from human hair: Evaluation in a rabbit model of lethal liver injury (2008)

Effective hemostatic dressings that are compatible with tissues are needed. Keratins are a class of biomaterials that can be derived by extraction of proteins from human hair. We have recently discovered that keratin biomaterials have hemostatic characteristics and hypothesize that a keratin hydrogel having the ability to absorb fluid and bind cells may be an effective hemostat. The goal of this study was to test a keratin hydrogel and evaluate it compared to current hemostats. Thirty-two New Zealand white rabbits received a lethal liver injury. Eight animals each were assigned to negative control, QuickClot, HemCon bandage, and keratin treatment groups. Vital stats and other data were recorded during surgery and all surviving animals were sacrificed after 72 h. Histology was conducted on all surviving animals. Twenty-four-hour survival rates were 0%, 62.5%, 62.5%, and 75% for the negative control, QuickClot, HemCon, and keratin groups, respectively. Other outcomes included blood loss, mean arterial pressure, heart rate, shock index, and liver histology. All of the hemostats were statistically better than the negative control group at late operative time points. The keratin group consistently performed as well as, or better than, the commercial hemostats. Histology showed an interesting healing response at the hemostat-liver interface in the keratin group.
The TASCC of Secretion (2011)

Cells can spatially couple cellular degradation and protein synthesis to boost protein secretion.
Operator Workload: Comprehensive Review and Evaluation of Operator Workload Methodologies (1989)

Abstract : This report documents the results of an analysis of the scientific literature on operator workload. It begins with an extensive discussion of the concept and definitions of operator workload. The main body of the report is a review and analysis of techniques that have been used for assessing operator workload. These techniques are classified into two broad categories: a) analytical or predictive techniques that may be applied early in system design, and b) empirical or evaluative techniques that must be obtained with an operator-in-the-loop during simulator, prototype, or system evaluations. Information from the review provides practical guidance for selecting the most appropriate techniques for various system and resource characteristics. Keywords: Workload; Human performance; MANPRINT(Manpower and Personnel Integration); Man machine relations; Measurements.
Uveal coloboma associated with amniotic band syndrome. (1983)

A baby girl had constriction bands and digital amputations typical of the amniotic band syndrome, as well as a typical uveal coloboma in a slightly microphthalmic eye. A small, free-floating amniotic band may have lodged in the fetal uveal cleft at 5 to 6 weeks of gestation, preventing closure of the cleft and thus resulting in this first reported instance of an association between amniotic band syndrome and an isolated uveal coloboma.
DSphere: A Source-Centric Approach to Crawling, Indexing and Searching the World Wide Web (2007)

We describe DSphere - a decentralized system for crawling, indexing, searching and ranking of documents in the World Wide Web. Unlike most of the existing search technologies that depend heavily on a page-centric view of the Web, we advocate a source-centric view of the Web and propose a decentralized architecture for crawling, indexing and searching the Web in a distributed source-specific fashion. A fully decentralized crawler is developed to crawl the World Wide Web where each peer is assigned the responsibility of crawling a specific set of documents referred to as a source collection. Link analysis techniques are used for ranking documents. Traditional link analysis techniques suffer from problems like slow refresh rate and vulnerabilities to Web Spam. We propose a source-based link analysis approach, which computes fast and accurate ranking scores for all crawled documents.
Comma-Free Ternary Triorthogonal Code (1969)

This paper shows the existence of a ternary triorthogonal code and a comma-free ternary triorthogonal code. Some theorems are proved for their existence and some algorithms for generating these codes are developed. For a dictionary of size $D = 3^{n + 1} $ and word length $L = 3^n $, the former code exists for any positive integer n and the latter code exists for $n > 1$. The ternary elements $\{ 0,1,2\} $ used in the codes are isomorphic, under the one-to-one correspondence, to the triphase vectors $\{ e^{(2\pi i/3 )r} ,r = 0,1,2\}$. The modulo 3 addition of $\{ 0,1,2\} $ and the triphase vector multiplication are also isomorphic under the one-to-one correspondence.
Some Basic Questions about Two Popular Adaptive Algorithm Modifications (1985)

Two adaptive algorithm modifications are considered: leakage and sign operator use. Simplisistic examples are used to demonstrate performance tradeoffs of parameter offset due to leakage and redefinition of adequately exciting input sequences with sign operator use.
Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists (2018)

While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5'-methylamides as A<sub>3</sub> adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). In an effort to increase OR and decrease AR affinity by structure activity analysis of this series, antagonist activity at κ-(K)OR appeared in 5'-esters (ethyl <b>24</b> and propyl <b>30</b>), which retained TSPO interaction (μM). 7-Deaza modification of C2-(arylethynyl)-5'-esters but not 4'-truncation enhanced KOR affinity (MRS7299 <b>28</b> and <b>29</b>, <i>K</i> <sub>i</sub> ≈ 40 nM), revealed μ-OR and DOR binding, and reduced AR affinity. Molecular docking and dynamics simulations located a putative KOR binding mode consistent with the observed affinities, placing C7 in a hydrophobic region. 3-Deaza modification permitted TSPO but not OR binding, and 1-deaza was permissive to both; ribose-restored analogues were inactive at both. Thus, we have repurposed a known AR nucleoside scaffold for OR antagonism, with a detailed hypothesis for KOR recognition.
ChemInform Abstract: Silicon Nanocrystals and Silicon‐Polymer Hybrids: Synthesis, Surface Engineering, and Applications (2016)

Abstract Review: [101 refs.
The Cyclisation Reactions of g-Amidoalcohols and Synthesis of 2-Benzazepin-3-one Derivatives by Acid Catalysed Rearrangement of 1,3-Oxazepin-4-one Derivatives (1977)

The cyclisation reaction of the secondary amides (I), possessing a hydroxyl group at y-position, with formalin and hydrochloric acid gave the 1,3-ouazepin-4-one derivatives Similarly, N-benzyl derivative (15b).m.p. 214 -216O [YmaX 3570,
Supplementary Figure 1 from Nonclassical Antigen-Processing Pathways Are Required for MHC Class II–Restricted Direct Tumor Recognition by NY-ESO-1–Specific CD4<sup>+</sup> T Cells (2023)

&lt;p&gt;PDF file - 110K, Cell surface molecules expressed on SK-MEL-37.&lt;/p&gt;
In vivo drug-drug interaction studies- A survey of all new molecular entities approved from 1987 to 1997 (2000)

Ninety-eight new molecular entities applications approved between 1987 to 1991 (period I) and 193 applications for new molecular entities between 1992 to 1997 (period II) were surveyed for drug-drug interaction studies. In period I (used as a comparator), 32 applications contained drug-drug interaction studies for a total of 117 studies. In period II, 106 applications reported drug-drug interaction studies, and the number of studies per new molecular entity ranged from 0 to 15. Most studies (77%) were performed in healthy subjects, with 44% using crossover designs, 7% using parallel designs, and the remaining using fixed sequence designs. The most common dosing scheme for new molecular entities/interacting drug was multiple dose (47%), whereas single dose/multiple dose was used in 31% of studies, and single dose/single dose was used in 18% of studies. Of the 540 drug-drug interaction studies submitted in period II, 80 (15%) resulted in clinically significant labeling statements. Submissions for new molecular entities to the Center for Drug Evaluation and Research divisions most likely to include drug-drug interaction studies were neuropharmacology, cardiorenal, antiviral, and antiinfective drugs. Some drug classes such as oncology drug products and radioimaging products were least likely to include drug-drug interaction studies in their submissions. We conclude that the use of drug-drug interaction studies in the drug development process has increased between the two periods.
Supporting Mobile Business Workflow with Commune (2006)

We propose Commune, a workflow management system that supports a mobile workforce. We introduce the "mini-workflow", a network-isolated subcomponent of a business workflow process. Mini-workflows enable subsets of business workflow to be off-loaded into mobile client environments by leveraging Web services. We describe how mini-workflows overcome the challenges of intermittent connectivity and we describe our BPEL-based implementation
Cover Picture: Controlled Release of Encapsulated Bioactive Volatiles by Rupture of the Capsule Wall through the Light‐Induced Generation of a Gas (Angew. Chem. Int. Ed. 7/2015) (2015)

Like the peel of an orange the shell of core–shell capsules protects and encapsulates flavors and fragrances against premature degradation. To release the aroma in both cases, the peel or the shell has to be mechanically broken. In their Communication on page 2275 ff., D. L. Berthier, A. Herrmann, and co-workers report that co-encapsulation of 2-oxoacetates allows the light-triggered release of fragrances by photochemically generating a gas overpressure that ruptures the capsule wall without relying on additional mechanical pressure. Like the peel of an orange the shell of core–shell capsules protects and encapsulates flavors and fragrances against premature degradation. To release the aroma in both cases, the peel or the shell has to be mechanically broken. In their Communication on page 2275 ff., D. L. Berthier, A. Herrmann, and co-workers report that co-encapsulation of 2-oxoacetates allows the light-triggered release of fragrances by photochemically generating a gas overpressure that ruptures the capsule wall without relying on additional mechanical pressure. Isotope Effects In their Communication on page 2052 ff., W. Ma, J. Zhao, and co-workers elucidated a proton-induced pathway for the TiO2-mediated photochemical dehalogenation of non-adsorbable aromatic bromides with an inverse kinetic solvent isotope effect.1 Synthetic Methods The intermolecular dearomatization of β-naphthols with aziridines using a chiral Mg catalyst is reported by R. Wang et al. in their Communication on page 2185 ff. The products could be transformed into a polycyclic core skeleton and a polyhydroxylated compound.1 Chromophores K. Müllen and co-workers describe in their Communication on page 2285 ff. versatile synthetic methods to transform the long-established dye perylene-3,4:9,10-tetracarboxylic diimide (PDI) into novel chromophores.1
Interaction-induced mode switching and threshold condensation in steady-state microlasers (2016)

In this talk we discuss two novel effects in steady state microlasers. The first one is interaction-induced mode switching (IMS), where the onset of a new lasing mode switches off an existing mode via a negative power slope. It's a deterministic effect in steady state lasing and caused by cross saturation of the gain medium, hence it's different from dynamic mode switching or hopping. For a fixed pump profile, a simple analytic criterion for the occurrence of IMS is given in terms of their self- and cross-interaction coefficients and non-interacting thresholds, which is verified for the example of a two-dimensional microdisk laser. When the spatial pump profile is varied as the pump power is increased, IMS can be induced even when it would not occur with a fixed pump profile, as we show for two coupled laser cavities.
COMMENTARY: Pre-emptive Nutrition: Refining the Targets of Drugs Targeted to Colorectal Cancer (2015)

It is suggested that our current understanding of the role of nutrients in maintaining genomic stability might be strategically employed alongside current chemotherapy, in order to prevent the emergence of drug resistant tumors and optimize medicinal chemistry approaches.
Alkene–Arene meta Photocycloadditions with a Four‐Carbon‐Atom Tether: Efficient Approach toward the Polycyclic Ring Systems of Aphidicolin and Stemodinone (2005)

Die Kette ist geschlossen! Die Kondensation des sechsgliedrigen Rings an die C4-Kette des Substrats 1 eröffnet einen effizienten Zugang zu den polycyclischen Ringsystemen der Naturstoffe Aphidicolin und Stemodinon. Die Reaktion ist insofern einzigartig, als in einem intramolekularen System bevorzugt das Produkt entsteht, das sich von einem endo-Exciplex ableitet (exo:endo 2:3=1.0:1.2).
Study of the Beckmann rearrangement of acetophenone oxime over porous solids by means of solid state NMR spectroscopy (2009)

The Beckmann rearrangement of acetophenone oxime using zeolite H-beta and silicalite-N as catalysts has been investigated by means of (15)N and (13)C solid state NMR spectroscopy in combination with theoretical calculations. The results obtained show that the oxime is N-protonated at room temperature on the acid sites of zeolite H-beta. At reaction temperatures of 423 K or above, the two isomeric amides, acetanilide and N-methyl benzamide (NMB) are formed, and interact with the Brønsted acid sites of zeolite H-beta through hydrogen bonds. The presence of residual water hydrolyzes the two amides, while larger amounts inhibit the formation of NMB and cause the total hydrolysis of the acetanilide. Over siliceous zeolite silicalite-N, containing silanol nests as active sites, the oxime is adsorbed through hydrogen bonds and only acetanilide is formed at reaction temperatures of 423 K or above. In the presence of water, the reaction starts at 473 K, still being very selective up to 573 K, and the amide is partially hydrolyzed only above this temperature .
Cubosomes from hierarchical self-assembly of poly(ionic liquid) block copolymers (2017)

Cubosomes are micro- and nanoparticles with a bicontinuous cubic two-phase structure, reported for the self-assembly of low molecular weight surfactants, for example, lipids, but rarely formed by polymers. These objects are characterized by a maximum continuous interface and high interface to volume ratio, which makes them promising candidates for efficient adsorbents and host-guest applications. Here we demonstrate self-assembly to nanoscale cuboidal particles with a bicontinuous cubic structure by amphiphilic poly(ionic liquid) diblock copolymers, poly(acrylic acid)-block-poly(4-vinylbenzyl)-3-butyl imidazolium bis(trifluoromethylsulfonyl)imide, in a mixture of tetrahydrofuran and water under optimized conditions. Structure determining parameters include polymer composition and concentration, temperature, and the variation of the solvent mixture. The formation of the cubosomes can be explained by the hierarchical interactions of the constituent components. The lattice structure of the block copolymers can be transferred to the shape of the particle as it is common for atomic and molecular faceted crystals.
Do individual and institutional predictors of misconduct vary by country? Results of a matched-control analysis of problematic image duplications (2022)

Pressures to publish, perverse incentives, financial interest and gender are amongst the most commonly discussed risk factors for scientific misconduct. However, evidence of their association with actual data fabrication and falsification is inconclusive. A recent case-controlled analysis of articles containing problematic image duplications suggested that country of affiliation of first and last authors is a significant predictor of scientific misconduct. The same analysis found null or negative associations with individual proxies of publication rate, impact and gender. The latter findings, in line with previous evidence, failed to support common hypotheses about the prevalence and causes of misconduct, but country-level effects may have confounded these results. Here we extend and complete previous results by comparing, via matched-controls analysis, articles from authors in the same country. We found that evidence for individual-level risk factors may be significant in some countries, and null or opposite in others. In particular, in countries where publications are rewarded with cash incentives, and especially China, the risk of problematic image duplication was higher for more productive, more frequently cited, earlier-career researchers working in lower-ranking institutions, in accordance with a "misaligned incentives" explanation for scientific misconduct. However, a null or opposite pattern was observed in all other countries, and especially the USA, UK and Canada, countries where concerns for misaligned incentives are commonly expressed. In line with previous results, we failed to observe a statistically significant association with industry funding and with gender. This is the first direct evidence of a link between publication performance and risk of misconduct and between university ranking and risk of misconduct. Commonly hypothesised individual risk factors for scientific misconduct, including career status and productivity, might be relevant in countries where cash-reward policies generate perverse incentives. In most scientifically active countries, however, where other incentives systems are in place, these patterns are not observed, and other risk factors might be more relevant. Policies to prevent and correct scientific misconduct may need to be tailored to a countries' or institutions' specific context.
Chick Chorioallantoic Membrane (CAM) Assays as a Model of Patient-Derived Xenografts from Circulating Cancer Stem Cells (cCSCs) in Breast Cancer Patients (2022)

The number of tumorspheres cultured from peripheral blood and the success rate of establishing PDX directly reflect the aggressiveness and proliferation capacity of the primary tumor. A CAM-based PDX model using cCSC provides a fast, low-cost, easy to handle, and powerful preclinical platform for drug screening, therapy optimization, and biomarker discovery.
Synthetic Utility of Yeast Hexokinase. Substrate Specificity, Cofactor Regeneration, and Product Isolation (1997)

Yeast hexokinase (EC 2.7.1.1) catalyzes the phosphorylation of pyranose and furanose analogs of glucose at 0.01-125% of the rate of glucose. The enzyme is highly tolerant of structural changes at C-2 and C-3 of glucopyranose and less tolerant of changes at C-1 and C-4. Preparative phosphorylations were performed on compounds having 0.01-100% of the activity of glucose, using phosphoenolpyruvate and pyruvate kinase to regenerate ATP. The effects of inhibition of hexokinase by phosphoenolpyruvate and acetyl phosphate on cofactor regeneration are discussed.
Dual-Band Lumped-Element Bandpass Filter (2006)

In this study, a dual-band lumped-element bandpass filter (DBLEF) is presented, which is implemented in low-temperature co-fired ceramic. The design utilizes the tight component coupling possible in this technology to mimic a much more complex network of lumped components. The filter is unique in that it utilizes only a single set of lumped components to create a dual-passband response. Detailed design equations are presented for the dual-band design, and a DBLEF having passbands at 2.4 and 5.2 GHz is demonstrated, representing the common wireless local area network bands. This paper both introduces a novel approach to lumped-element dual-band filtering, while also demonstrating an effective method of implementing this complex filter in multilayer technology with a very small footprint. Both measured and simulated results verify the approach with the overall size of the filter only 154times135times22.8 mil <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> (3.85times3.38times0.57 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> )
Preparation, Characterization, and Antiviral Activity of Microbial Metabolites of Stemodin (1991)

Screening studies for microbial transformation products of stemodin [2] have identified a number of microbial metabolites. Scale-up fermentation with Rhizopus arrhizus ATCC 11145 and Streptomyces sp. NRRL 5691 have resulted in the production of five metabolites that have been characterized with the use of 2D nmr and X-ray techniques. These metabolites have been identified as 18-hydroxystemodin [6], 16,18-dihydroxystemodin [7], 8 beta-hydroxystemodin [8], 8 beta, 18-dihydroxystemodin [9], and 7 beta, 8 beta-dihydroxystemodin [10]. The antiviral activity and cytotoxicity of the isolated metabolites have been evaluated.
Practical nano-chemistry (2006)

(2006). Practical nano-chemistry. Science and Technology of Advanced Materials: Vol. 7, 21st COE Program, Waseda University, ‘Practical Nano-Chemistry’. Edited by H. Nishide, T. Momma and K. Tatsuta, pp. 395-396.
Antinociceptive activity of the new triple reuptake inhibitorNS18283 in a mouse model of chemotherapy‐induced neuropathic pain (2014)

Acute administration of drugs that enhance the activity of serotonin, norepinephrine and dopamine neurotransmission within nociceptive pathways may provide a broader spectrum of antinociception than dual or selective reuptake inhibitors in animal models of neuropathic pain. Whether similar observations would occur after repeated administration of such compounds in an attempt to simulate dosing in humans, or be compromised by dopaminergic-mediated adverse effects warrants further investigation.
Complexation of Phosphine Ligands with Peracetylated β-Cyclodextrin in Supercritical Carbon Dioxide:  Spectroscopic Determination of Equilibrium Constants (2007)

The interaction between peracetylated beta-cyclodextrin and several triphenyl phosphine derivatives was studied in supercritical carbon dioxide (scCO2) by UV-visible spectroscopy. The equilibrium constant for a 1:1 complexation reaction was obtained from titration spectra and calculated using two established mathematical models. The values of the equilibrium constants are 1-3 orders of magnitude smaller than those obtained in aqueous solution with analogous phosphines. This is likely due to the absence in scCO2 of the hydrophobic effect, which is replaced by a corresponding, but weaker, CO2-phobic effect. The largest value of Kf was found for complexes of diphenyl(4-adamantylphenyl)phosphine, which is rationalized on the basis of the excellent fit of the phosphine in the cyclodextrin cavity, leading to enhanced host-guest van der Waals interactions. This study can be considered the first step toward the comprehension of the complexation thermodynamics of modified cyclodextrins soluble in scCO2.
An update to applications of open standards to test automation to board-level testing (2002)

An application of open standard formats to board-level test was described in a paper presented at AUTOTESTCON 1993. This paper provides an update to this work, including descriptions of the problems encountered and solutions developed in applying such standards to two specific printed circuit boards and two automatic test systems (ATSs): the GenRad 2751 and a Modular Automatic Test Equipment (MATE) compatible system. A complete test automation flow process developed around these open standards and data formats is described, including the specific software tools developed, and the input and output requirements of each tool.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>