gebhart/patrepeval huggingface dataset:
Molecular modeling of vasopressin receptor andin silicoscreening of V1b receptor antagonists (2013)

Several innovative protein engineering techniques and crystallographic methods have greatly accelerated SBDD, not only for already-resolved GPCRs but also for those structures which remain unclear. These technological advances are expected to enable the determination of GPCR-fragment complexes, making it practical to perform fragment-based drug discovery. This paves the way for a new era of GPCR-targeted drug discovery.
Epidemiology, etiology, and pathogenesis of tendinopathy among athletes (2021)

The treatment of tendinopathy can be challenging for clinicians and might be associated with serious adverse events. However, evidence shows that tendinopathy can significantly impact the professional careers of the affected athletes. The main clinical features of the condition include decreased performance and strength of the affected tendons, swelling, and localized pain. Although tendinopathy might seem a non-critical condition, estimates show that it might be career-ending for many professional athletes, and therefore, reducing their quality of life. In the present literature review, we have discussed the epidemiology, etiology, and pathogenesis of tendinopathy among athletes. Different intrinsic and extrinsic factors were found to contribute to the development of the condition and the impact of various systemic diseases. Evidence also shows that the prevalence of the condition is high among athletes. However, these rates were variable across the different studies in the literature. This is probably owing to various factors, like demographics and the process of detection. The pathogenesis of the condition is also very complicated, and the development of pain has been attributed to the process of angiogenesis and associated ingrowth of nerve fibers.
Multiple oral dosing of valacyclovir in horses and ponies (2008)

The aim of the current study was to investigate whether multiple oral dosing of valacyclovir could result in plasma concentrations exceeding the EC(50)-value of acyclovir against equine herpesvirus 1 (EHV1) during the majority of the treatment period. Additionally, we wanted to determine the concentration of acyclovir in nasal mucus and cerebrospinal fluid (CSF). Valacyclovir was administered to four horses and two ponies, three times daily, at a dosage of 40 mg/kg, for four consecutive days. Blood was collected prior to each administration and 1 h after dosing. Nasal mucus samples and CSF were collected once during treatment; 1 h after the last administration. This dosage regimen resulted in plasma concentrations that were higher than the EC(50)-value of 1.7 microg/mL, i.e. EC(50) of an isolate highly susceptible to acyclovir, for 80% of the treatment period; and higher than the EC(50)-value of 3.0 microg/mL, i.e. EC(50) of an isolate less susceptible to acyclovir, for 60% of the treatment period. Concentration in nasal mucus samples and CSF was 0.36-1.17 microg/mL and 0.11-0.23 microg/mL, respectively. This study illustrates that multiple dosing of valacyclovir may result in a therapeutic benefit as plasma concentrations could be maintained above the EC(50)-value of acyclovir against EHV1 for more than 50% of the treatment period. Acyclovir could be detected in both nasal mucus samples and CSF. However, these concentrations were lower than the EC(50).
A systematic comparison of structural, structural connectivity, and\n functional connectivity based thalamus parcellation techniques (2019)

The thalamus consists of several histologically and functionally distinct\nnuclei increasingly implicated in brain pathology and important for treatment,\nmotivating the need for development of fast and accurate thalamic segmentation.\nThe contrast between thalamic nuclei as well as between the thalamus and\nsurrounding tissues is poor in T1 and T2 weighted magnetic resonance imaging\n(MRI), inhibiting efforts to date to segment the thalamus using standard\nclinical MRI. Automatic segmentation techniques have been developed to leverage\nthalamic features better captured by advanced MRI methods, including\nmagnetization prepared rapid acquisition gradient echo (MP-RAGE) , diffusion\ntensor imaging (DTI), and resting state functional MRI (fMRI). Despite\noperating on fundamentally different image features, these methods claim a high\ndegree of agreement with the Morel stereotactic atlas of the thalamus. However,\nno comparison has been undertaken to compare the results of these disparate\nsegmentation methods. We have implemented state-of-the-art structural,\ndiffusion, and functional imaging-based thalamus segmentation techniques and\nused them on a single set of subjects. We present the first systematic\nqualitative and quantitative comparison of these methods. We found that\nfunctional connectivity-based parcellation exhibited a close correspondence\nwith structural parcellation on the basis of qualitative concordance with the\nMorel thalamic atlas as well as the quantitative measures of Dice scores and\nvolumetric similarity index.\n
Augmenting Transformer-Transducer Based Speaker Change Detection With Token-Level Training Loss (2022)

In this work we propose a novel token-based training strategy that improves Transformer-Transducer (T-T) based speaker change detection (SCD) performance. The conventional T-T based SCD model loss optimizes all output tokens equally. Due to the sparsity of the speaker changes in the training data, the conventional T-T based SCD model loss leads to sub-optimal detection accuracy. To mitigate this issue, we use a customized edit-distance algorithm to estimate the token-level SCD false accept (FA) and false reject (FR) rates during training and optimize model parameters to minimize a weighted combination of the FA and FR, focusing the model on accurately predicting speaker changes. We also propose a set of evaluation metrics that align better with commercial use cases. Experiments on a group of challenging real-world datasets show that the proposed training method can significantly improve the overall performance of the SCD model with the same number of parameters.
Somatic Mutation in Human T-Cell Leukemia Virus Type 1 Provirus and Flanking Cellular Sequences During Clonal Expansion In Vivo (2001)

These data indicate that, in vivo, HTLV-1 variation results mainly from postintegration events that consist of somatic mutations of the proviral sequence occurring during clonal expansion. The finding of substitutions in flanking sequences suggests that somatic mutations occurring after integration, presumably coupled with selection, help move the cellular clones toward a transformed phenotype, of which adult T-cell leukemia/lymphoma is the end point.
An integrated multifunction DC/DC converter for PV generation systems (2010)

Due to the stochastic characteristic of photovoltaic (PV) generation, energy storage devices are indispensable to smooth the power flow and provide the electric energy with high quality. In this paper, an integrated DC/DC converter is proposed to realize high performance interfaces for PV array, battery and load. This converter consists of a boost converter for the PV array and a buck/boost converter for the battery, which can realize multifunction including power generation, charge and discharge. The grid-connected and stand-alone operation modes of this converter are analyzed. From this analysis, the control strategies are developed for both modes. A coordination scheme is proposed for the power balance at the stand-alone mode. Simulation and experiments verify the practical feasibility and effectiveness of this multi-function converter.
SUMCASTEC_190109_NA_EuMW18 Poster_Conference Poster_.pdf_Bath_I. Davies_Public_Amended (2019)

Poster presented by Ilan Davies at the IEEE European Microwave Week, Madrid Spain, 26th September 2018.
Relationship Functioning and Gut Microbiota Composition among Older Adult Couples (2023)

An emerging area of research extends work on couple functioning and physical health to gut health, a critical marker of general health and known to diminish with age. As a foray into this area, we conducted a pilot study to (1) determine the feasibility of remote data collection, including a fecal sample, from older adult couples, (2) examine within-couple concordance in gut microbiota composition, and (3) examine associations between relationship functioning and gut microbiota composition. Couples (N = 30) were recruited from the community. The participants' demographic characteristics were as follows: M (SD) age = 66.6 (4.8), 53% female, 92% White, and 2% Hispanic. Two of the couples were same-sex. All 60 participants completed self-report measures and supplied a fecal sample for microbiome analysis. Microbial DNA was extracted from the samples, and the 16S rRNA gene V4 region was amplified and sequenced. The results indicated that individuals shared more similar gut microbial composition with their partners than with others in the sample, <i>p</i> < 0.0001. In addition, individuals with better relationship quality (greater relationship satisfaction and intimacy and less avoidant communication) had greater microbial diversity, <i>p</i> < 0.05, a sign of healthier gut microbiota. Further research with a larger and more diverse sample is warranted to elucidate mechanisms.
Simulation of oil bioremediation in a tidally influenced beach: Spatiotemporal evolution of nutrient and dissolved oxygen (2016)

Abstract Numerical experiments of oil bioremediation of tidally influenced beach were simulated using the model BIOMARUN. Nutrient and dissolved oxygen were assumed present in a solution applied on the exposed beach face, and the concentration of these amendments was tracked throughout the beach for up to 6 months. It was found that, in comparison to natural attenuation, bioremediation increased the removal efficiency by 76% and 65% for alkanes and aromatics, respectively. Increasing the nutrient concentration in the applied solution did not always enhance biodegradation as oxygen became limiting even when the beach was originally oxygen‐rich. Therefore, replenishment of oxygen to oil‐contaminated zone was also essential. Stimulation of oil biodegradation was more evident in the upper and midintertidal zone of the beach, and less in the lower intertidal zone. This was due to reduced nutrient and oxygen replenishment, as very little of the amendment solution reached that zone. It was found that under continual application, most of the oil biodegraded within 2 months, while it persisted for 6 months under natural conditions. While the difference in duration suggests minimal long‐term effects, there are situations where the beach would need to be cleaned for major ecological functions, such as temporary nesting or feeding for migratory birds. Biochemical retention time map (BRTM) showed that the duration of solution application was dependent upon the stimulated oil biodegradation rate. By contrast, the application rate of the amendment solution was dependent upon the subsurface extent of the oil‐contaminated zone. Delivery of nutrient and oxygen into coastal beach involved complex interaction among amendment solution, groundwater, and seawater. Therefore, approaches that ignore the hydrodynamics due to tide are unlikely to provide the optimal solutions for shoreline bioremediation.
Reactions of chemically adsorbed monolayers induced by electron beam irradiation in active gas atmosphere and applications for the preparation of multilayers (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of chemically adsorbed monolayers induced by electron beam irradiation in active gas atmosphere and applications for the preparation of multilayersKazufumi Ogawa, N. Mino, H. Tamura, and M. HatadaCite this: Langmuir 1990, 6, 4, 851–856Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/la00094a024https://doi.org/10.1021/la00094a024research-articleACS PublicationsRequest reuse permissionsArticle Views71Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Invited paper: Secure swarm intelligence: A new approach to many-core power management (2017)

This paper presents a visionary proposal for a distributed (or decentralized) power/thermal control mechanism that applies the bio-inspired artificial intelligence paradigm of swarm intelligence. The target use case is a future many-core processor. The paper reports a high-level concept-phase specification of the proposed solution approach in a research setting. The emphasis is on highlighting the key challenges and pitfalls that must be dealt with in transitioning this research into full product deployment.
Hydrothermal and Magmatic Reservoirs of the Lazufre Volcanic Area Revealed from High-resolution Seismic Noise Tomography. (2014)

Author: Spica, Zack et al.; Genre: Journal Article; Finally published : 2015; Title: Hydrothermal and magmatic reservoirs at Lazufre volcanic area, revealed by a high-resolution seismic noise tomography
Reduction of mechanical loading in tendons induces heterotopic ossification and activation of the β-catenin signaling pathway (2021)

Tendon heterotopic ossification detrimentally affect quality of life especially for those who has atheletic career. This study reveals the possible mechanism of heterotpic ossification in tendon related to mechanical loading. This study provided the possible to develop a mechanical stimulation protocol for preventive and therapeutic purpose for tendon heterotopic ossification.
Programmable metamaterials & metasurfaces for ultra-compact multi-functional photonics (2019)

We demonstrate the design and experimental verification of several examples of programmable metamaterials and metasurfaces. Such devices offer the advantage of high-density integration and versatility.
2-Anilinonicotinyl linked 1,3,4-oxadiazole derivatives: Synthesis, antitumour activity and inhibition of tubulin polymerization (2011)

A series of 2-anilinonicotinyl linked 1,3,4-oxadiazoles was synthesized and evaluated for their antitumour activity against various cancer cell lines, inhibition of tubulin polymerization and cell cycle effects. Some of these compounds showed good antiproliferative activity with GI50 values ranging from 4.57 to 97.09 μM in the human cancer cell lines and one of the compounds 5m showed potent antitumour efficacy in all the cell lines tested. This compound also inhibited tubulin polymerization under both in vitro and in vivo conditions. Analysis of tubulin by Western blot experiments demonstrated that 5m depolymerizes microtubules by causing disturbances in the ratio of soluble versus polymerized tubulin in cells, leading to the cell cycle arrest at G2/M phase of the cell cycle followed by activation of caspase-3 activity and apoptotic cell death.
Platelet‐derived microparticles regulates thrombin generation via phophatidylserine in abdominal sepsis (2017)

Sepsis is associated with dysfunctional coagulation. Recent data suggest that platelets play a role in sepsis by promoting neutrophil accumulation. Herein, we show that cecal ligation and puncture (CLP) triggered systemic inflammation, which is characterized by formation of IL-6 and CXC chemokines as well as neutrophil accumulation in the lung. Platelet depletion decreased neutrophil accumulation, IL-6, and CXC chemokines formation in septic lungs. Depletion of platelets increased peak thrombin formation and total thrombin generation (TG) in plasma from septic animals. CLP elevated circulating levels of platelet-derived microparticles (PMPs). In vitro generated PMPs were a potent inducer of TG. Interestingly, in vitro wild-type recombinant annexin V abolished PMP-induced thrombin formation whereas a mutant annexin V protein, which does not bind to phosphatidylserine (PS), had no effect. Administration of wild-type, but not mutant annexin V, significantly inhibited thrombin formation in septic animals. Moreover, CLP-induced formation of thrombin-antithrombin complexes were reduced in platelet-depleted mice and in animals pretreated with annexin V. PMP-induced TG attenuated in FXII- and FVII-deficient plasma. These findings suggest that sepsis-induced TG is dependent on platelets. Moreover, PMPs formed in sepsis are a potent inducer of TG via PS exposure, and activation of both the intrinsic and extrinsic pathway of coagulation. In conclusion, these observations suggest that PMPs and PS play an important role in dysfunctional coagulation in abdominal sepsis.
Supplementary Figure 2 from Bcl9/Bcl9l Are Critical for Wnt-Mediated Regulation of Stem Cell Traits in Colon Epithelium and Adenocarcinomas (2023)

Supplementary Figure 2 from Bcl9/Bcl9l Are Critical for Wnt-Mediated Regulation of Stem Cell Traits in Colon Epithelium and Adenocarcinomas
Multicast routing for real-time communication of high-speed networks (1996)

Real-time network applications, e.g., multimedia applications and critical control applications, are evolving at a fast pace. These applications are resource-intensive, have stringent delay requirements, and in many cases involve more than two participants. Efficient multicast communication mechanisms are, therefore, necessary to support real-time applications. In this dissertation, we study five routing problems for real-time communication on high-speed connection-oriented wide-area networks. The objective of all problems we study is to optimize the utilization of the network resources without violating the delay requirements of real-time applications. We focus primarily on multicast routing problems, but we consider also the special cases of broadcast routing and unicast routing.
ChemInform Abstract: Proton Acid‐Induced Rearrangements of α‐Alkynylestradiol Methyl Ethers. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
GLEANS: A Generator of Logical Extracts and Abstracts for Nice Summaries (2002)

We describe GLEANS, a summarization system that uses four novel techniques for summarizating document collections. (i) GLEANS first maps all documents in a collection into a canonical, database-like representation that makes explicit the main entities and relations in a document collection. (ii) GLEANS also classifies each document collection into one of four categories: collections about a single person, single event, multiple event, and natural disaster. (iii) For each type of document collection, GLEANS generates a short headline using a set of predefined templates. For multi-event documents, GLEANS also generates from scratch, using predefined templates, the first two sentences in the abstract. (iv) The rest of the summary is then generated by extracting from the database sentences that conform to a set of predefined schemas and by presenting them in an order that reflects coherence constraints specific to each collection category.
The intelligent container as a part of the Internet of Things (2012)

Perishables need special conditions within the food supply chain like temperature or humidity. There is a lack of information along the food supply chain (FSC) concerning temperatures for perishable goods. By integrating the Intelligent Container (IC) within the Internet of Things the lack of information will be eliminated and thus wastes of food will be reduced. The first step for this integration is to analyze common techniques in modeling supply chains and especially the FSC and create a model taking into consideration the concept of the IC. On this basis, technologies to generate information along the FSC are shown and the IC is linked to the Internet of Things. Finally, a logistic reference model will be deduced from the Internet of Things for perishables.
Anthranilamide–Pyrazolo[1,5‐a]pyrimidine Conjugates as p53 Activators in Cervical Cancer Cells (2012)

A library of new anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates were designed, synthesized, and evaluated for their anticancer activity in cervical cancer cells such as HeLa and SiHa that possess low levels of p53. All 24 conjugates showed antiproliferative activity, while some of them exhibit significant cytotoxicity. In assays related to cell-cycle distribution, these conjugates induced G(2) /M arrest in HeLa cells and G(1) cell-cycle arrest in SiHa cells. Immunocytochemistry assays revealed that these compounds cause nuclear translocation of p53, thereby indicating the activation of p53. In cervical cancer cells, the p53 protein is degraded by E6 oncoprotein. Immunoblot and RT-PCR analyses proved the presence of mitochondria-mediated apoptosis with involvement p53 target genes such as BAX, Bcl2, and p21 (CDKI). Moreover, these compounds increased the phosphorylated forms of p53 and provide signals for apoptosis induction. Interestingly, one of the conjugates, (2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl)(4-(2-(thiophen-2-ylmethylamino)benzoyl)piperazin-1-yl)methanone, is the most promising candidate in this series and has the potential to be taken up for further detailed studies.
Hybrid Plasmons for Manipulating Molecular and Excitonic Energy Redistribution Pathways (2007)

The availability of multiple molecular energy redistribution pathways following photoexcitation plays a fundamental role in limiting the yield of a targeted photochemical or photophysical outcome such as photoluminescence or photoinduced charge separation. Optical methods such as ultrafast coherent control have thus been used to try to alter and direct energy flow within molecules. We report here a new approach to this problem by harnessing strong coupling of molecular electronic states with tunable surface plasmon resonances to control electronic energy redistribution pathways in molecules adsorbed on a silver film [1]. In our experiments. ultrafast excitation of porphyrinic molecular J-aggregates into the S2 state is followed by a second pulse of varying incident wavevector to produce a tunable plasmon in the metal film. When the plasmon overlaps the S1 state, energy flows from S2 to S1 at high efficiency through a surface plasmon gated internal conversion. The conversion yield is controlled by the intensity of the gated signal (i.e. the surface plasmon). If the plasmon hybridizes with the S2 state (strong coupling regime), the excitation remains in the S2 vibrational manifold during quenching to the ground state. The redistribution process is analogous to an ultrafast molecular optical transistor where the SPP is the gating signal, the S1 state corresponds to the drain and the S2 state to the source (see Fig. 1)