gebhart/patrepeval huggingface dataset:
Robust CT ventilation from the integral formulation of the Jacobian (2019)

The mathematical theory underpinning the IJF method allows for the generation of ventilation images that are (a) computed with respect to DIR spatial accuracy on the digital voxel grid and (b) based on DIR-measured subregional volume change estimates acquired with quantifiable and controllable levels of uncertainty. Analyses of the experiments are consistent with the mathematical theory and indicate that IJF ventilation imaging has a higher reproducibility with respect to both DIR algorithm and CT acquisition method, in comparison to the standard finite difference approach.
Front Matter: 7528 (2010)

This PDF file contains the front matter associated with SPIE Proceedings volume 7528, including the Title Page, Copyright information, Table of Contents, Introduction, and the Conference Committee listing.
Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections (2017)

Ivacaftor caused marked reductions in sputum P. aeruginosa density and airway inflammation and produced modest improvements in radiographic lung disease in subjects with G551D-CFTR mutations. However, P. aeruginosa airway infection persisted. Thus, measures that control infection may be required to realize the full benefits of CFTR-targeting treatments.
When nanophotonics meet thin crystalline-silicon photovoltaics (2015)

11-18 sept. 2015
Linkage analysis of late‐infantile neuronal ceroid‐lipofuscinosis (1995)

The neuronal ceroid-lipofuscinoses (NCL) are a group of neurodegenerative disorders with an autosomal-recessive pattern of inheritance. There are 3 main categories of childhood NCL, namely, infantile, late-infantile, and juvenile NCL. These can be distinguished on the basis of age of onset, clinical course, and histopathology. A number of variant forms of NCL have also been described, and these show symptoms intermediary between the main classical forms. The genes for both the infantile and juvenile forms of NCL have previously been mapped to chromosome areas 1p32 and 16p12, respectively. The gene for late-infantile NCL (LINCL), CLN2, has been excluded from both these loci, but its location is as yet unknown. Recently, CLN5, the gene for the Finnish variant form of LINCL, was mapped to 13q21.1-32. Using the 3 microsatellite markers which were most tightly linked to CLN5, we have excluded CLN2 from this region using a subset of 17 families. Thus, CLN2 represents a fourth distinct genetic locus involved in the pathogenesis of NCL.
Hierarchically-Structured Ti/TiO<sub>2</sub> Electrode for Hydrogen Evolution Synthesized via 3D Printing and Anodization (2020)

Hierarchically-structured, electro-catalysts consisting of a titanium core with controlled macro-porosity and a thin titania surface-layer with controlled nano-porosity were synthesized via combination of additive manufacturing and in-situ anodization. The electrodes were tested for hydrogen evolution reaction and depicted competitive electro-catalytic activities, with Tafel slopes between 40 and 56 mV dec-1. The electrodes also depicted competitive onset and over potentials when compared with other electrode alternatives. The synthesis approach for the electro-catalysts reported in this work is being extended to other metal/metal-oxide pairs and applications.
Active damping of the SOFIA Telescope assembly (2012)

The NASA/DLR Stratospheric Observatory for Infrared Astronomy (SOFIA) employs a 2.5-meter reflector telescope in a Boeing 747SP. The telescope is housed in an open cavity and is subjected to aeroacoustic and inertial disturbances in flight. To meet pointing requirements, SOFIA must achieve a pointing stability of approximately 0.5 arcseconds RMS. An active damping control system is being developed for SOFIA to reduce image jitter and image degradation due to resonance of the telescope assembly. Our paper discusses the history of the active damping design for SOFIA, from early concepts to the current implementation which has recently completed a ground and flight testing for proof-of-concept. We describe some milestones in the analysis and testing of the telescope assembly which guided the development of the vibration control system. The control synthesis approach and current implementation of the active damping control system is presented. Finally, we summarize the performance observed in early flight tests and the steps that are currently foreseen to completing the development of this system.
ChemInform Abstract: Synthesis of β‐Carbolines from Aldehydes and Ketones via the α‐Siloxy α,β‐Unsaturated Esters. (2010)

Abstract An efficient synthesis of β‐carbolines via acid‐promoted condensation of tryptamine or tryptophane with α‐siloxy‐α,β‐unsaturated esters is described.
Miniature Optical Connector with Magnetic Physical Contact (2020)

We present a miniature physical-contact optical connector featuring a novel magnetic attraction structure. The magnetic optical connectors we designed and fabricated yield low insertion and high return losses comparable to those of a conventional connector.
Inactivation of C30A Trimethylamine Dehydrogenase by N-Cyclopropyl-α-methylbenzylamine, 1-Phenylcyclopropylamine, and Phenylhydrazine (2001)

Trimethylamine dehydrogenase (TMADH) from the bacterium Methylophilus methylotrophus (sp. W(3)A(1)) and its C30A mutant were inactivated with three known inactivators of monoamine oxidase, namely, phenylhydrazine, N-cyclopropyl-alpha-methylbenzylamine, and 1-phenylcyclopropylamine. All three compounds irreversibly inactivated both the wild-type and C30A mutant enzymes, although phenylhydrazine was 10 times more potent than N-cyclopropyl-alpha-methylbenzylamine, which was much more potent than 1-phenylcyclopropylamine. The change in the UV--visible absorption spectra upon modification indicated that the flavin was modified. In the case of the C30A mutant, the absence of a covalent attachment of the flavin to the polypeptide has permitted LC-electrospray mass spectrometry of the reaction product to be undertaken, demonstrating new mass peaks corresponding to various chemically modified forms of the flavin cofactor. In the case of N-cyclopropyl-alpha-methylbenzylamine, masses corresponding to hydroxy-FMN and hydroxyriboflavin were detected. 1-Phenylcyclopropylamine inactivation of the C30A mutant produced three modified flavins, as evidenced by the electrospray mass spectrum: hydroxy-FMN, FMN plus C(6)H(5)COCH(2)CH(2), and hydroxy-FMN plus C(6)H(5)COCH(2)CH(2). Phenylhydrazine inactivation of the C30A mutant gave at least seven different modified flavins: hydroxyriboflavin, hydroxy-FMN, two apparently isomeric compounds corresponding to hydroxy-FMN plus one phenyl group, two apparently isomeric compounds corresponding to FMN plus one phenyl group, and FMN plus two phenyl groups. Covalent flavin adduct formation appears to be the only modification because dialysis of the inactive enzyme followed by reconstitution with FMN restores the enzyme activity to that of a noninactivated control.
Carbon nanohorns allow acceleration of osteoblast differentiationviamacrophage activation (2016)

Carbon nanohorns (CNHs), formed by a rolled graphene structure and terminating in a cone, are promising nanomaterials for the development of a variety of biological applications. Here we demonstrate that alkaline phosphatase activity is dramatically increased by coculture of human monocyte derived macrophages (hMDMs) and human mesenchymal stem cells (hMSCs) in the presence of CNHs. CNHs were mainly localized in the lysosome of macrophages more than in hMSCs during coculturing. At the same time, the amount of Oncostatin M (OSM) in the supernatant was also increased during incubation with CNHs. Oncostatin M (OSM) from activated macrophage has been reported to induce osteoblast differentiation and matrix mineralization through STAT3. These results suggest that the macrophages engulfed CNHs and accelerated the differentiation of mesenchymal stem cells into the osteoblast via OSM release. We expect that the proof-of-concept on the osteoblast differentiation capacity by CNHs will allow future studies focused on CNHs as ideal therapeutic materials for bone regeneration.
Re: Editorial Comment (1997)

No AccessJournal of UrologyClinical Urology: Letter to the Editor1 Jun 1997Re: Editorial Comment S.L. Goldenberg, M.E. Gleave, N. Bruchovsky, and P. Rennie S.L. GoldenbergS.L. Goldenberg More articles by this author , M.E. GleaveM.E. Gleave More articles by this author , N. BruchovskyN. Bruchovsky More articles by this author , and P. RennieP. Rennie More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64759-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Editorial Comment." The Journal of Urology, 157(6), p. 2267 References 1 : Effects of intermittent diethylstilbestrol diphosphate administration on the R3327 rat prostatic carcinoma. Cancer Res.1987; 47: 5967. Google Scholar 2 : Effects of intermittent androgen suppression on androgen-dependent tumors. Apoptosis and serum prostate-specific antigen. Cancer1993; 71: 2782. Google Scholar 3 : Intermittent androgen suppression delays progression to androgen-independent regulation of prostate-specific antigen gene in the LNCaP tumour model. J. Steroid. Biochem. Mol. Biol.1996; 58: 139. Google Scholar Division of Urology, Department of Surgery, University of British Columbia, Vancouver General Hospital (S. L. Goldenberg, M. E. Gleave).Department of Cancer Endocrinology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada (N. Bruchovsky and P. Rennie).© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byGrossfeld G, Small E and Carroll P (2018) Intermittent Androgen Deprivation for Clinically Localized Prostate Cancer: Initial ExperienceJournal of Urology, VOL. 160, NO. 1, (270-271), Online publication date: 1-Jul-1998. Volume 157Issue 6June 1997Page: 2267 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information S.L. Goldenberg More articles by this author M.E. Gleave More articles by this author N. Bruchovsky More articles by this author P. Rennie More articles by this author Expand All Advertisement PDF downloadLoading ...
An integrated 200W class D audio amplifier (2002)

An integrated stereo class D audio power amplifier realized in an SOI based BCD technology is presented. The limiting factor in the performance of class D amplifiers is the quality of the switching power stage. In this paper a new high-speed, low-current levelshifter and a robust deadtime control arrangement are presented that are essential for a high quality switching power stage.
Review of pediatric encephalitis and encephalopathy cases following immunization reported to the Canadian Immunization Monitoring Program Active (IMPACT) from 1992 to 2012 (2020)

Encephalopathy/encephalitis following immunization remains a rare but serious adverse event. Most cases had another more likely etiology than vaccination. Continued monitoring and analysis of AEFI is paramount to ensure the safety of immunization programs.
Computerized Assessment of Human Neurotoxicity (1986)

Interdisciplinary Programs in Health and the Occupational Health Program, Harvard School of Public Health and Forsyth Dental Center, Boston, Massachusetts
Computational Multiplex Panel Reduction to Maximize Information Retention in Breast Cancer Tissue Microarrays (2022)

ABSTRACT Recent state-of-the-art multiplex imaging techniques have expanded the depth of information that can be captured within a single tissue sample by allowing for panels with dozens of markers. Despite this increase in capacity, space on the panel is still limited due to technical artifacts, tissue loss, and long imaging acquisition time. As such, selecting which markers to include on a panel is important, since removing important markers will result in a loss of biologically relevant information, but identifying redundant markers will provide a room for other markers. To address this, we propose computational approaches to determine the amount of shared information between markers and select an optimally reduced panel that captures maximum amount of information with the fewest markers. Here we examine several panel selection approaches and evaluate them based on their ability to reconstruct the full panel images and information within breast cancer tissue microarray datasets using cyclic immunofluorescence as a proof of concept. We show that all methods perform adequately and can re-capture cell types using only 18 of 25 markers (72% of the original panel size). The correlation-based selection methods achieved the best single-cell marker mean intensity predictions with a Spearman correlation of 0.90 with the reduced panel. Using the proposed methods shown here, it is possible for researchers to design more efficient multiplex imaging panels that maximize the amount of information retained with the limited number of markers with respect to certain evaluation metrics and architecture biases. Author Summary Multiplex tissue imaging techniques utilize large panels of markers that attempt to gather as much information as possible, but increasing the number of stains does come with the downsides of increased autofluorescence and tissue degradation. There exists a theoretical subsampling of markers that is able to recreate the same information as a full panel; therefore, removing the self-correlating information with such a subset would increase the efficiency of the imaging process and maximize the information collected. By selecting an idealized subsample of markers, a deep learning model can be trained to predict the same information as a full dataset with fewer rounds of staining. Here we evaluate several methods of subsample marker selection and demonstrate their ability to reconstruct the full panel’s information.
Speckle and Metrology (2020)

One could argue whether speckle metrology is an imaging or a nonimaging application of speckle. On the one hand, most speckle interferometry systems have an imaging system that is used in gathering information. On the other hand, it is not the image of the object that is really of interest; rather it is information about mechanical properties of the object, such as movement, vibration modes, or surface roughness, that is desired. For this reason, plus the fact that speckle metrology is a well-developed field on its own, we have chosen to have a separate chapter devoted to this subject. While speckle has been a nuisance in almost all of the applications we have discussed previously, in the field of metrology, speckle is put to good use. Applications that use speckle for measurements of displacements arose in the late 1960s and early 1970s, often as an alternative to holographic interferometry. The field of speckle metrology has so many facets and so many applications that it is difficult to do it justice in a single chapter. At best we can only scratch the surface of such a rich and diverse field. We therefore restrict our goals to introducing some of the basic concepts while referring the reader to the more detailed treatments referenced above for a more in-depth study and more complete bibliographies.
Contribution of plasmid-encoded peptidase S8 (PrtP) to adhesion and transit in the gut of Lactococcus lactis IBB477 strain (2017)

The ability of Lactococcus lactis to adhere to the intestinal mucosa can potentially prolong the contact with the host, and therefore favour its persistence in the gut. In the present study, the contribution of plasmid-encoded factors to the adhesive and transit properties of the L. lactis subsp. cremoris IBB477 strain was investigated. Plasmid-cured derivatives as well as deletion mutants were obtained and analysed. Adhesion tests were performed using non-coated polystyrene plates, plates coated with mucin or fibronectin and mucus-secreting HT29-MTX intestinal epithelial cells. The results indicate that two plasmids, pIBB477a and b, are involved in adhesion of the IBB477 strain. One of the genes localised on plasmid pIBB477b (AJ89_14230), which encodes cell wall-associated peptidase S8 (PrtP), mediates adhesion of the IBB477 strain to bare, mucin- and fibronectin-coated polystyrene, as well as to HT29-MTX cells. Interactions between bacteria and mucus secreted by HT29-MTX cells were further investigated by fluorescent staining and confocal microscopy. Confocal images showed that IBB477 forms dense clusters embedded in secreted mucus. Finally, the ability of IBB477 strain and its ΔprtP deletion mutant to colonise the gastrointestinal tract of conventional C57Bl/6 mice was determined. Both strains were present in the gut for up to 72 h. In summary, adhesion and persistence of IBB477 were analysed by in vitro and in vivo approaches, respectively. Our studies revealed that plasmidic genes encoding cell surface proteins are more involved in the adhesion of IBB477 strain than in the ability to confer a selective advantage in the gut.
Performance Evaluation of MIMO in IEEE802.16e/WiMAX (2008)

The methodology used to evaluate the performance of the various MIMO schemes in orthogonal frequency division multiplexing (OFDM) WiMAXWiMAX stands for Worldwide Interoperability for Microwave Access. systems is described. The per-tone signal-to-noise plus interference ratio (SINR) of a MIMO OFDM system is derived in a multi user, multicell and multisector communication system. The sector average spectral efficiency for a coded MIMO OFDM system is evaluated under a single frequency reuse deployment scenario. It is shown that the second antenna at the subscriber station receiver provides significant gains over single transmit single receive antenna (SISO) systems. The rate 2 spatial multiplexing MIMO scheme on the downlink improves the sector spectral efficiency by 10% over single transmit and two receive antenna (SIMO) system in a single frequency reuse deployment. It is also shown that in a time-division duplex (TDD) WiMAX system, the gain in downlink spectral efficiency from beamforming can be very large if the delay between the uplink channel estimate and the downlink beamforming is small compared to the coherence time of the channel. On the uplink, it is shown that the collaborative spatial multiplexing increases the spectral efficiency by 9% over a SIMO system with the same number of receive antennas at the base station (BS). Significant gains in uplink spectral efficiency are seen with more antennas at the BS and by using uplink beamforming as compared to SISO.
The data quality of haematological malignancy ICD-10 diagnoses in a population-based Hospital Discharge Registry (2005)

The objectives of this study were to estimate the data quality of haematological malignancy diagnoses in a hospital discharge registry, and to quantify the impact of any misclassification of diagnoses on survival estimates. We included all patients > or = 15 years living in North Jutland County, Denmark with a first-time discharge diagnosis of a haematological malignancy registered in the Hospital Discharge Registry and the Danish Cancer Registry, the reference standard, from 1994 to 1999. We estimated completeness and positive predictive value (PPV) of haematological malignancies and specific subcategories, as a measure of data quality, and compared mortality rates based on data from the two registries by Cox regression analysis. Completeness in the Hospital Discharge Registry for all haematological malignancies was 91.5% (95% confidence interval (CI) 89.6-93.1) and PPV was 84.5% (95% CI 82.2-86.5). Reviews of the pathological files showed misclassified cases in both registries and thus indicated that both completeness and PPV of the Hospital Discharge Registry were underestimates. Mortality rate ratio for all haematological malignancies when registered in the Hospital Discharge Registry compared with being registered in the Danish Cancer Registry was 0.98 (95% CI 0.88-1.09). Discharge data had some misclassifications but these had no major impact on survival estimates.
B211 A liquid-piston steam engine (2011)

A novel liquid-piston steam engine which attains high efficiency in the low-temperature region at <300℃, as well as high reliability and low cost has been developed. Sintered metal was employed in the heating section to obtain high evaporation rate. The proposed engine achieved a thermal efficiency of 12.7% which was approximately 40% of the Carnot efficiency working at a heating temperature of 270℃ and a cooling temperature of 80℃. The liquid piston steam engine can be expected as a promising energy conversion device for waste heat below 300℃.
Association of Diabetes With Central Corneal Thickness Among a Multiethnic Asian Population (2019)

These findings suggest that diabetes and hyperglycemia were associated with thicker CCT. This study provides useful information on the interpretation of intraocular pressure in patients with diabetes.
Modification of polymers in the melt (2001)

The kinetics of polymer-analogue reactions in the melt are discussed with the example of conversions of styrene copolymers including anhydride or nitrile groups in the side chain and additives with amino and hydroxyl groups. Poly(styrene-co-maleic anhydride) has been modified with primary alcohols and amines, secondary amines, diamines, amino acids and amino alcohols. Poly(styrene-co-acrylonitrile) has been modified with various amino alcohols.
Synthesis and performance of a series of novel low-molecular-weight superplasticisers with star-shaped phosphate frame (2019)

A new type of small-molecule phosphate superplasticiser (SP) was synthesised in one pot by the phosphorylation reaction of star-polyether with phosphoric acid. By varying the structure of the initiator polyamines, star-shaped small-molecule phosphate SPs with different molecular weights and anionic charge densities were prepared. The synthesised SPs were characterised by means of proton nuclear magnetic resonance, high-performance liquid chromatography, Fourier transform infrared spectroscopy and gel permeation chromatography. Their dispersion ability, adsorption behaviour and retardation effect on cement hydration were investigated. It was proved that the star-shaped small-molecule phosphate compounds with longer polyether chains and more phosphate groups could be successfully applied as anti-clay SPs. The findings provide useful information for optimising the performance of phosphated small-molecule chemical admixtures in the future.
Versatile Homoallylic Boronates by Chemo‐, SN2′‐, Diastereo‐ and Enantioselective Catalytic Sequence of Cu−H Addition to Vinyl‐B(pin)/Allylic Substitution (2016)

Abstract A highly chemo‐, diastereo‐ and enantioselective catalytic method that efficiently combines a silyl hydride, vinyl‐B(pin) (pin=pinacolato) and (E)‐1,2‐disubstituted allylic phosphates is introduced. Reactions, best promoted by a Cu‐based complex with a chiral sulfonate‐containing N‐heterocyclic carbene, are broadly applicable. Aryl‐, heteroaryl‐, alkenyl‐, alkynyl‐ and alkyl‐substituted allylic phosphates may thus be converted to the corresponding homoallylic boronates and then alcohols (after C−B bond oxidation) in 46–91 % yield and in up to &gt;98 % S N 2′:S N 2 ratio, 96:4 diastereomeric ratio and 98:2 enantiomeric ratio. The reasons why an NHC−Cu catalyst is uniquely effective (vs. the corresponding phosphine systems) and the basis for different trends in stereoselectivity are provided with the aid of DFT calculations.
Multiple Double XTEM Sample Preparation of Sub-10 nm Diameter Si Nanowires (2010)

Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.