gebhart/patrepeval huggingface dataset:
An Approach for a Synthesis of Asparagine‐Linked Sialylglycopeptides Having Intact and Homogeneous Complex‐Type Undecadisialyloligosaccharides (2006)

This paper describes synthesis of asparagine-linked sialylglycopeptides. The typical feature of our strategy for the synthesis of a sialylglycopeptide is to employ undecadisialyloligosaccharyl Fmoc-asparagine (Fmoc-Asn(CHO)-OH) 1 without protecting groups on its hydroxyl groups except for the benzyl ester of the NeuAc residues. Our synthetic methodology solved the problem of esterification toward sugar hydroxyl groups by activated amino acids during the elongation of a peptide chain. When employing high concentrations of the Fmoc-amino acid, esterification markedly occurred, but the esterification scarcely occurred when employing low concentrations of reactants. Taking advantage of these findings, we examined the synthesis of a high molecular sialylglycopeptide, CTLA-4 fragment (113-150) 13 having two complex-type sialyloligosaccharides by use of native chemical ligation (NCL). As a result, we succeeded in the synthesis of a sialylglycopeptide having a cysteine residue at the N-terminus (CTLA-4: 129-150 fragment) 11 and a sialylglycopeptide-thioester (CTLA-4: 113-128 fragment) 12. Finally, the sialylglycopeptides synthesized were applied to NCL reactions. The reaction successfully afforded the desired product, CTLA-4 (113-150) 13 containing mature and pure complex-type sialyloligosaccharides in excellent purity.
First Cognitive Radio Networking Standard for Personal/Portable Devices in TV White Spaces (2010)

Recent FCC rules allowing unlicensed use on a secondary basis of the Television White Spaces (TVWS) promise a whole new set of possible applications. The first step towards realizing these applications is the creation and adoption of industry standards. In this paper we present the first such standard for personal/portable devices in the TVWS that complies fully with the existing FCC rules while retaining flexibility for use with other regulatory domains. We describe the physical (PHY) and medium access control (MAC) layers specified in the standard and present performance results to demonstrate the robustness and spectral efficiency of the proposed protocols.
Development of a Practical Synthesis of a p38 MAP Kinase Inhibitor (2009)

A practical synthesis of the phthalazine-based p38 MAP kinase inhibitor [(S)-2] was needed for an ongoing program. Vibrational circular dichroism provided the assignment of the absolute stereochemistry of the target compound. The selected synthetic route for (S)-2 required identification of efficient reaction conditions for the construction of carbon−oxygen, carbon−carbon, and carbon−nitrogen bonds to connect the key building blocks. An efficient two-step method (chlorodehydroxylation, aromatic nucleophilic substitution) for the synthesis of arylether [(S)-10] was developed. PAT (in situ Raman spectroscopy) was utilized to monitor and control the formation of a lithium alkoxide in this reaction. The synthesis of (S)-2 was completed using high-yielding Suzuki- and amide-coupling reactions. The isolation conditions for these steps were optimized to obtain material of very high purity without the need for any complicated workup procedures.
Simple high efficiency red phosphorescent organic light-emitting diodes without LiF electron injection layer (2009)

Simple high efficiency red phosphorescent organic light-emitting diodes (PHOLEDs) without any electron injection layer were developed using a phosphine oxide derivative as a triplet host and electron transport material. Electrons could be directly injected from the Al cathode to the phosphine oxide type material. A high quantum efficiency of 12.5% and a high power efficiency of 12.7 lm W−1 were achieved in the red PHOLEDs without any electron injection layer. In addition, the red PHOLED without any electron transport and electron injection layer also showed a high quantum efficiency of 10.5% and a power efficiency of 10.2 lm W−1.
H∞ feedback and feedforward controller design for active vibration isolators (2017)

Active vibration isolation is essential for industrial high-precision systems to suppress both floor vibrations and direct disturbance forces. This paper proposes a systematic H∞ feedback and feedforward controller design to suppress both types of disturbances with minimum amplification of sensor noise. Regarding the latter, parametric disturbance and noise models are used in the design. The resulting H∞ controller is shown to have disturbance rejection properties similar to a manually tuned controller but with less noise amplification and actuator drift.
Silicon based devices for demanding high power applications (2018)

This paper gives an overview of the recent progress of high voltage silicon based power devices for high power grid applications, traction- and industrial drives. The first part of the paper covers the latest developments of thyristor based technologies whereas the second and third part focuses on IGBT-type devices and the corresponding packaging technologies.
A heat-stable microparticle platform for oral micronutrient delivery (2019)

Micronutrient deficiencies affect up to 2 billion people and are the leading cause of cognitive and physical disorders in the developing world. Food fortification is effective in treating micronutrient deficiencies; however, its global implementation has been limited by technical challenges in maintaining micronutrient stability during cooking and storage. We hypothesized that polymer-based encapsulation could address this and facilitate micronutrient absorption. We identified poly(butylmethacrylate-co-(2-dimethylaminoethyl)methacrylate-co-methylmethacrylate) (1:2:1) (BMC) as a material with proven safety, offering stability in boiling water, rapid dissolution in gastric acid, and the ability to encapsulate distinct micronutrients. We encapsulated 11 micronutrients (iron; iodine; zinc; and vitamins A, B2, niacin, biotin, folic acid, B12, C, and D) and co-encapsulated up to 4 micronutrients. Encapsulation improved micronutrient stability against heat, light, moisture, and oxidation. Rodent studies confirmed rapid micronutrient release in the stomach and intestinal absorption. Bioavailability of iron from microparticles, compared to free iron, was lower in an initial human study. An organotypic human intestinal model revealed that increased iron loading and decreased polymer content would improve absorption. Using process development approaches capable of kilogram-scale synthesis, we increased iron loading more than 30-fold. Scaled batches tested in a follow-up human study exhibited up to 89% relative iron bioavailability compared to free iron. Collectively, these studies describe a broad approach for clinical translation of a heat-stable ingestible micronutrient delivery platform with the potential to improve micronutrient deficiency in the developing world. These approaches could potentially be applied toward clinical translation of other materials, such as natural polymers, for encapsulation and oral delivery of micronutrients.
Speech Enhancement For Mobile Telephony Based On Non-Uniformly Spaced Frequency Resolution (1998)

Publication in the conference proceedings of EUSIPCO, Rhodes, Greece, 1998
Unusual electrocardiographic presentation of right ventricular myocardial infarction. (1996)

Isolated right ventricular infarction is uncommon, but when it occurs its prompt recognition may alter therapy substantially. Electrocardiographic changes accompanying acute right ventricular infarction are variable and may be difficult to recognize. The case of a 40-year-old man who had right ventricular infarction with unusual electrocardiographic findings is presented. The clinical, hemodynamic, and electrocardiographic findings of right ventricular infarction are discussed.
Characterization of human endothelial cell urokinase-type plasminogen activator receptor protein and messenger RNA (1990)

Human umbilical vein endothelial cells in culture (HUVEC) express receptors for urokinase-type plasminogen activators (u-PA). The immunochemical nature of this receptor and its relationship to u-PA receptors expressed by other cell types is unknown. Cross-linking active site-blocked u-PA to HUVEC lead to an increase in its apparent molecular mass by approximately 40 Kd. The predominant u-PA binding protein isolated from whole cell detergent extracts migrated with a molecular mass of approximately 36 Kd using affinity chromatography. In contrast, when only cell surface proteins were radiolabeled before extraction, the predominant labeled u-PA binding protein isolated migrated with a molecular mass of approximately 46 Kd. Several pieces of evidence suggested that the difference in molecular mass between these two u-PA binding proteins resulted from glycosylation of a single receptor protein. First, a polyclonal antibody against u-PA receptor isolated from phorbol myristate acetate (PMA) stimulated U-937 cells reacted with both the 36- and 46-Kd proteins on Western blotting. Second, the size of the unmodified receptor was estimated by amplifying a full-length cDNA for u-PA receptor from an endothelial cell cDNA library using the polymerase chain reaction (PCR) and oligonucleotide primers corresponding to the DNA sequence of the receptor cloned from transformed human fibroblasts (Roldan et al, EMBO J 9:467, 1990). The size of the cDNA (approximately 1,054 base pairs, bp) and the presence of a single 1.4-kilobase (Kb) mRNA transcript on Northern blot analysis predict an unglycosylated receptor protein of approximately 35 Kd. Third, synthesis of 35S-labeled 46-Kd cell surface receptor protein was inhibited when the cells were grown in the presence of tunicamycin, while the synthesis of the 36-Kd species was unaffected. Moreover, the apparent molecular mass of purified surface-labeled receptor (approximately 46 Kd) was reduced by N-glycanase. These studies suggest that the u-PA receptor on the surface of HUVEC is a glycoprotein derived from a protein of approximately 35 Kd which is similar immunologically to u-PA receptors on other cell types.
Evaluating the interaction of bacteria with biomaterials using atomic force microscopy (1998)

Bacterial infection of biomaterials represents one of the most important reasons for the failure of transdermal or implanted medical devices. The first and least understood step in biomaterial-associated infections is the initial interaction between bacteria and a surface. This initial interaction can be either attractive or repulsive depending on the physiochemical nature of the biological and synthetic surfaces, as well as the properties of the interstitial fluid. We have shown that atomic force microscopy (AFM) can be employed as an exquisitely sensitive and versatile tool for quantifying the interaction between bacteria and surfaces in physiological solutions. The forces of interaction between an AFM cantilever tip and a uniform lawn of bacteria immobilized on glass were determined. By comparing the interactions of cantilever tips with lawns of isogenic E. coli strains carrying genetic lesions that alter their cell surface composition, it was possible to evaluate the effect of macromolecules such as lipopolysaccharide and capsular polysaccharide on the adhesion process. Mutations that result in the synthesis of truncated lipopolysaccharide or in the overproduction of the negatively charged capsular polysaccharide colanic acid render the interaction of the bacteria with the AFM tip unfavorable due to increased electrostatic repulsion. Furthermore, AFM could be used to evaluate the adhesion of bacteria onto commercially relevant biomaterials. In one approach, micron-size polystyrene beads were attached to AFM tips which were then used to measure forces. Unfortunately, this approach is limited by the meager number of materials manufactured as beads of a size suitable for AFM measurements. As an alternative approach, AFM cantilever tips were coated with a confluent layer of bacteria and used to probe planar surfaces. In this configuration, AFM could be employed to measure the force of interaction between virtually any bacterium and surface of interest.
Multicell LMMSE Filtering Capacity under Correlated Multiple BS Antennas (2010)

Multicell joint processing has been shown to efficiently suppress inter-cell interference, while providing a high capacity gain due to spatial multiplexing across distributed Base Stations (BSs). However, the complexity of the optimal joint decoder in the multicell uplink channel grows exponentially with the number of users, making it prohibitive to implement in practice. In this direction, this paper investigates the uplink capacity performance of multicell joint linear minimum mean square error (LMMSE) filtering, followed by single-user decoding. The considered cellular multiple-access channel model assumes both Rayleigh and Rician flat fading, path loss, distributed users and correlated multiple antennas at the base station side. The case of Rayleigh fading is tackled using a free probability approach, while the case of Rician fading is addressed through a deterministic equivalent calculated using non-linear programming techniques. In this context, it is shown that LMMSE can provide high spectral efficiencies in practical macrocellular scenarios.
A different mirror (1994)

Mirrors grown in the crystalline structure ease manufacture of vertical-cavity lasers, which emit collimated circular beams and can form large two-dimensional arrays. The authors discuss the fabrication of the surface emitting laser mirrors. By means of techniques such as molecular beam epitaxy and metal-organic vapor phase epitaxy, hundreds of layers of semiconductor materials can be grown one on top of the other. By mixing and matching the materials to create "designer" alloys, it is possible to grow a crystalline structure with all the electrical and optical properties desired for its various parts. This method of tailoring semiconductor structures is called bandgap engineering. The principles of the mirrors and their applications are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Draft Genome Sequence of Pseudomonas syringae pv. tomato T1 Reveals a Type III Effector Repertoire Significantly Divergent from That of Pseudomonas syringae pv. tomato DC3000 (2008)

Diverse gene products including phytotoxins, pathogen-associated molecular patterns, and type III secreted effectors influence interactions between Pseudomonas syringae strains and plants, with additional yet uncharacterized factors likely contributing as well. Of particular interest are those interactions governing pathogen-host specificity. Comparative genomics of closely related pathogens with different host specificity represents an excellent approach for identification of genes contributing to host-range determination. A draft genome sequence of Pseudomonas syringae pv. tomato T1, which is pathogenic on tomato but nonpathogenic on Arabidopsis thaliana, was obtained for this purpose and compared with the genome of the closely related A. thaliana and tomato model pathogen P. syringae pv. tomato DC3000. Although the overall genetic content of each of the two genomes appears to be highly similar, the repertoire of effectors was found to diverge significantly. Several P. syringae pv. tomato T1 effectors absent from strain DC3000 were confirmed to be translocated into plants, with the well-studied effector AvrRpt2 representing a likely candidate for host-range determination. However, the presence of avrRpt2 was not found sufficient to explain A. thaliana resistance to P. syringae pv. tomato T1, suggesting that other effectors and possibly type III secretion system-independent factors also play a role in this interaction.
Electrocatalytic metal hydride generation using concerted proton electron transfer mediators (2021)

The electrochemical generation of metal hydride (M H) species remains one of the major hurdles for a wide range of catalytic reactions to be carried out electrochemically. We introduce here a new strategy for electrocatalytic M H generation using concerted proton electron transfer (CPET) mediators. We investigate the combination of a series of CPET mediators with the CO2 electroreduction catalyst [MnI(bpy)(CO)3Br] (bpy = 2,2’-bipyridine), probing the reversal of the product selectivity from CO to HCOOH to evaluate the efficiency of the M H generation step. We demonstrate the formation of the manganese-hydride by in-situ spectroscopic techniques and determine the thermodynamic boundary conditions for this mechanism to occur. A synthetic iron-sulfur cluster is identified as the best CPET-mediator for that system, enabling the preparation of a benchmark catalytic system for HCOOH generation.
Cleaning of AlN and GaN surfaces (1998)

Successful ex situ and in situ cleaning procedures for AlN and GaN surfaces have been investigated and achieved. Exposure to HF and HCl solutions produced the lowest coverages of oxygen on AlN and GaN surfaces, respectively. However, significant amounts of residual F and Cl were detected. These halogens tie up dangling bonds at the nitride surfaces hindering reoxidation. The desorption of F required temperatures &amp;gt;850 °C. Remote H plasma exposure was effective for removing halogens and hydrocarbons from the surfaces of both nitrides at 450 °C, but was not efficient for oxide removal. Annealing GaN in NH3 at 700–800 °C produced atomically clean as well as stoichiometric GaN surfaces.
Efficient Single Photon Generation using a Fiber-integrated Diamond Micro-Waveguide (2015)

We demonstrate the efficient coupling of a diamond micro-waveguide containing a single nitrogen-vacancy center to a single mode optical fiber. Strong photon anti-bunching is observed with a raw single-photon count rate exceeding 712,000 Hz.
Evaluation of human brain tumor heterogeneity using multiple T1‐based MRI signal weighting approaches (2008)

Vascular-space-occupancy (VASO) MRI without contrast injection was explored for imaging cerebral blood volume (CBV) and tissue heterogeneity in gliomas (n = 10). VASO contrast complemented contrast-enhanced T(1)-weighted (GAD-T(1)w), FLAIR and T(1)w magnetization-prepared-rapid-gradient-echo (MPRAGE) images. High-grade gliomas showed a VASO-outlined hyperintense zone corresponding to long-T(1) regions in MPRAGE and to nonenhancing regions in GAD-T(1)w images. FLAIR, MPRAGE, and VASO data were used to segment tumors into multiple zones of different T(1). After removal of known resection areas using pre- and postsurgical MRI, the volume of overlap between the hyperintense VASO-zone and the long-T(1) MPRAGE zone correlated with that of GAD-T(1)w enhancement (R(2) = 0.99) and tumor grade. Based on these correlations, this remaining long T(1) overlap area was tentatively assigned to necrosis. In one promising case the collective T(1)-weighted approach accurately identified a low-grade glioma despite the presence of contrast enhancement in GAD-T(1)w images consequential to chemoradiation-associated treatment effect. The results suggest that this collective T(1)-weighted approach may provide useful information for regional assessment of heterogeneous tumors and for guiding treatment-related decisions in patients with gliomas.
Full PEEC Modeling of EMI Filter Inductors in the Frequency Domain (2013)

In this paper, the performance of a new method based on the coupling of the partial element equivalent circuit method and boundary integral method (the PEEC-BIM method) for 3D modeling of toroidal inductors, which are typically used in electromagnetic interference (EMI) filter applications, is presented. The presence of magnetic materials is modeled by replacing the surface of magnetic regions with an equivalent distribution of fictitious current loops. It is shown that the influence of the magnetic core on the impedance and the stray field of EMI filter inductors can be modeled and explained in detail by PEEC-BIM simulation results. The developed PEEC-BIM approach is verified by both 3D finite-element method (FEM) simulations and near-field measurements for different winding configurations and magnetic cores. Regarding computational complexity, the developed PEEC-BIM method applied to toroidal inductors performs extremely well. The PEEC-BIM simulation is at least twice faster than the corresponding FEM-based analysis. The PEEC-BIM method has been implemented in a PEEC-based simulation tool, which facilitates the simulation of entire EMI filter structures.
IP easy-pass: a light-weight network-edge resource access control (2005)

Providing real-time communication services to multimedia applications and subscription-based Internet access often requires that sufficient network resources be reserved for real-time traffic. However, the reserved network resource is susceptible to resource theft and abuse. Without a resource access control mechanism that can efficiently differentiate legitimate real-time traffic from attacking packets, the traffic conditioning and policing enforced at Internet Service Provider (ISP) edge routers cannot protect the reserved network resource from embezzlement. On the contrary to the usual expectation, the traffic policing at edge routers aggravates their vulnerability to flooding attacks by blindly dropping packets. In this paper, we propose a fast and lightweight IP network-edge resource access control mechanism, called IP Easy-pass, to prevent unauthorized access to reserved network resources at edge devices. We attach a unique pass to each legitimate real-time packet so that an ISP edge router can validate the legitimacy of the incoming IP packet very quickly and simply by checking its pass. We present the generation of Easy-pass, its embedding, and verification procedures. We implement the IP Easy-pass mechanism in the Linux kernel, and measure its overhead on our testbed. Finally, we demonstrate its effectiveness against packet forgery and resource embezzlement attempts by conducting a series of experiments.
Active vibration damping using smart material (1994)

We consider the modeling and active damping of an elastic beam using distributed actuators and sensors. The piezoelectric ceramic material (PZT) is used to build the actuator. The sensor is made of the piezoelectric polymer polyvinylidene fluoride (PVDF). These materials are glued on both sides of the beam. For the simple clamped beam, the closed loop controller has been shown to be able to extract energy from the beam. The shape of the actuator and its influence on the closed loop system performance are discussed. It is shown that it is possible to suppress the selected mode by choosing the appropriate actuator layout. It is also shown that by properly installing the sensor and determining the sensor shape we can further extract and manipulate the sensor signal for our control need.