gebhart/patrepeval huggingface dataset:
Sequential decisions on FAS sequencing guided by biomarkers in patients with lymphoproliferation and autoimmune cytopenia (2013)

Clinical and genetic heterogeneity renders confirmation or exclusion of autoimmune lymphoproliferative syndrome difficult. To re-evaluate and improve the currently suggested diagnostic approach to patients with suspected FAS mutation, the most frequent cause of autoimmune lymphoproliferative syndrome, we prospectively determined 11 biomarkers in 163 patients with splenomegaly or lymphadenopathy and presumed or proven autoimmune cytopenia(s). Among 98 patients sequenced for FAS mutations in CD3(+)TCRα/β(+)CD4(-)CD8(-) "double negative" T cells, 32 had germline and six had somatic FAS mutations. The best a priori predictor of FAS mutations was the combination of vitamin B12 and soluble FAS ligand (cut-offs 1255 pg/mL and 559 pg/mL, respectively), which had a positive predictive value of 92% and a negative predictive value of 97%. We used these data to develop a web-based probability calculator for FAS mutations using the three most discriminatory biomarkers (vitamin B12, soluble FAS ligand, interleukin-10) of the 11 tested. Since more than 60% of patients with lymphoproliferation and autoimmune cytopenia(s) in our cohort did not harbor FAS mutations, 15% had somatic FAS mutations, and the predictive value of double-negative T-cell values was rather low (positive and negative predictive values of 61% and 77%, respectively), we argue that the previously suggested diagnostic algorithm based on determination of double-negative T cells and germline FAS sequencing, followed by biomarker analysis, is not efficient. We propose vitamin B12 and soluble FAS ligand assessment as the initial diagnostic step with subsequent decision on FAS sequencing supported by a probability-calculating tool.
The status and advances in reservoir geophysics (1993)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1993The status and advances in reservoir geophysicsAuthors: Robert E. SheriffRobert E. SheriffUniversity of Houstonhttps://doi.org/10.1190/1.1822337 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1822337FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1993ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1993 Pages: 1396 publication data© 1993 Copyright © 1993 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Robert E. Sheriff, (1993), "The status and advances in reservoir geophysics," SEG Technical Program Expanded Abstracts : 1209-1209. https://doi.org/10.1190/1.1822337 Plain-Language Summary PDF DownloadLoading ...
A liquid ionisation detector for digital radiography of therapeutic megavoltage photon beams (1985)

Experiments with an ionisation detector were performed in order to determine whether it was possible to obtain high energy photon beam images for radiotherapy treatment verification. A small prototype detector with a field of view of 78 mm X 78 mm and constructed from printed circuit boards was used. The imaging area was a matrix ionisation chamber, filled with air or liquid (2,2,4-trimethylpentane). A minicomputer was used to control the data acquisition electronics and to reconstruct and restore the images. The images were displayed on a viewing console for computed tomography images. The liquid filled detector with a front-rear board separation of 1.0 mm gave the best results. The spatial resolution was about 3.8 mm with a density resolution of 0.5% for a data acquisition time of 120 s. Comparison of the liquid detector images with corresponding metal screen-film detector images showed that the image qualities were the same. An important advantage of the ionisation detector image is that grey scale modification, sharpening and smoothing by digital processing can easily be performed.
Synthesis of (+)‐(3R)‐3‐(4‐fluorophenylsulfonamido)‐1,2,3,4‐tetrahydro‐9‐[5,6,7,8,12,13‐U‐14C]carbazolepropanoic acid, [14C]BAY u 3405 (1994)

Abstract The title compound [ 14 C]BAY u 3405 ( 1 ) was synthesized as part of 8‐step sequence. Starting from [U‐ 14 C]aniline hydrogensulfate the final product 1 was obtained with a specific activity of 741 MBq/mmol (20 mCi/mmol) and a radiochemical purity of &gt; 98% in an overall yield of 6 and 10% depending on the method.
Photocrosslinkable Type-I Collagen for In Situ Material Modification (2011)

Hydrogels are attractive materials for use as tissue engineering scaffolds [1]. Natural hydrogels, such as collagen, are both cytocompatible and highly biofunctional. However, they have somewhat constrained material properties and have an inherently large variability in composition due to their biological origin, making them more difficult to work with from an engineering viewpoint[2–4]. Here, we aim to use type 1 collagen — the most abundant protein in the body that maintains excellent cytocompatibility and can self assemble into a fibrillar network — as a base component for a photocrosslinkable biomaterial. One main advantage of this system over previous studies attempting to photocrosslink collagen is that the collagen retains its ability to self assemble, which provides a stable environment into which localized modifications can be made to the stiffness, porosity, and biochemical properties of the hydrogel scaffold. By taking advantage of the spatial control provided by the system, we can create complex 3-dimensional hydrogel scaffolds that have non-homogenous microenvironments.
Uplink CDMA systems with diverse QoS guarantees for heterogeneous traffic (1997)

Addressed is the uplink access control problem for cellular CDMA systems that service heterogeneous traffic with various types of quality-of-service (&OS) and use Multi-Code CDMA (MC-CDMA) t o support variable bit rates. Considering its distinct QoS requirements, class-1 real-time traffic (e.g., voice and video) is differentiated from class-11 nonreal-time traffic (e.g., data). Connection-oriented transmission is achieved by assigning transmitter-oriented code channels for class-1 traffic where each corresponding mobile client needs to pass an admission test. Class-II traffic is transmitted in a best-effort manner using the bandwidth left unused by class-1 traffic and a transmission-rate request access scheme: whenever a mobile has class-11 messages to transmit, the mobile requests code channels via a receiveroriented transmission-request code channel, then, according to the base station scheduling, the transmission is scheduled and permitted. Addressed are the admission test for class-1 connections, power control, and how to maximize the aggregate throughput for class-11 trafiic. The admission region of voice and video connections and the optimum target signalto-interference ratio (SIR) of class-11 traftic are derived numerically. The performance of class-11 traffic transmissions in terms of average delay is also evaluated and discussed based on simulations. Indezz Terms-CDMA systems, wireless/mobile communication, Multi-Code CDMA, admission control, power control, QoS guarantees, transmission-rate request access protocol, Reed-Solomon/convolutional concatenated code, Automatic Retransmission reQuest (ARQ).
Microbe-focused glycan array screening platform (2019)

Interactions between glycans and glycan binding proteins are essential for numerous processes in all kingdoms of life. Glycan microarrays are an excellent tool to examine protein-glycan interactions. Here, we present a microbe-focused glycan microarray platform based on oligosaccharides obtained by chemical synthesis. Glycans were generated by combining different carbohydrate synthesis approaches including automated glycan assembly, solution-phase synthesis, and chemoenzymatic methods. The current library of more than 300 glycans is as diverse as the mammalian glycan array from the Consortium for Functional Glycomics and, due to its microbial focus, highly complementary. This glycan platform is essential for the characterization of various classes of glycan binding proteins. Applications of this glycan array platform are highlighted by the characterization of innate immune receptors and bacterial virulence factors as well as the analysis of human humoral immunity to pathogenic glycans.
Building Caries Risk Assessment Models for Children (2010)

decayed, missing, filled teeth in primary dentition (dmft); receiver operation characteristics (ROC); relative risk (RR); confidence interval (CI); National Institutes of Health (NIH); World Health Organization (WHO); US Department of Health and Human Services (US/DHHS); American Academy of Pediatric Dentistry (AAPD).
Postdoctoral progression is needed for doctors taking up clinical academic careers (2015)

Gulland’s article highlights the value to patients of doctors being involved in research.1 2 While this has been recognised in the NHS’s commitment to research,3 such involvement, we believe, must include sufficient numbers of doctors taking up clinical academic careers. Progress in healthcare requires that medically trained academics become principal investigators making significant …
Optical Monitoring and Treatment of Potentially Lethal Wound Infections In Vivo (2003)

We report on the use of optical techniques to monitor and treat Pseudomonas aeruginosa wound infections in mice. Bioluminescent bacteria transduced with a plasmid containing a bacterial lux gene operon allow the infection in excisional mouse wounds to be imaged by use of a sensitive charge-coupled device camera. Photodynamic therapy (PDT) targeted bacteria, by use of a polycationic photosensitizer conjugate, which is designed to penetrate the gram-negative cell wall and was topically applied to the wound and was followed by red-light illumination. There was a rapid light dose-dependent loss of luminescence, as measured by image analysis, in the wounds treated with conjugate and light, a loss that was not seen in untreated wounds, wounds treated with light alone, or wounds treated with conjugate alone. P. aeruginosa was invasive in our mouse model, and all 3 groups of control mice died within 5 days; in contrast, 90% of PDT-treated mice survived. PDT-treated wounds healed significantly faster than did silver nitrate-treated wounds, and this was not due to either inhibition of healing by silver nitrate or stimulation of healing by PDT.
Endotoxin-induced uveitis is partially inhibited by anti-IL-8 antibody treatment. (1999)

Anti-IL-8 antibody treatment partially blocks EIU in rabbits. A consistent decrease in the recruitment of polymorphonuclear leukocytes into the anterior chamber was obtained when neutralizing antibody was injected simultaneously with endotoxin. These findings suggest that IL-8 contributes to the chemotactic signal for the recruitment of leukocytes in EIU.
The products of the thermal decomposition of CH3CHO (2011)

We have used a heated 2 cm × 1 mm SiC microtubular (μtubular) reactor to decompose acetaldehyde: CH(3)CHO + Δ → products. Thermal decomposition is followed at pressures of 75-150 Torr and at temperatures up to 1675 K, conditions that correspond to residence times of roughly 50-100 μs in the μtubular reactor. The acetaldehyde decomposition products are identified by two independent techniques: vacuum ultraviolet photoionization mass spectroscopy (PIMS) and infrared (IR) absorption spectroscopy after isolation in a cryogenic matrix. Besides CH(3)CHO, we have studied three isotopologues, CH(3)CDO, CD(3)CHO, and CD(3)CDO. We have identified the thermal decomposition products CH(3) (PIMS), CO (IR, PIMS), H (PIMS), H(2) (PIMS), CH(2)CO (IR, PIMS), CH(2)=CHOH (IR, PIMS), H(2)O (IR, PIMS), and HC≡CH (IR, PIMS). Plausible evidence has been found to support the idea that there are at least three different thermal decomposition pathways for CH(3)CHO; namely, radical decomposition: CH(3)CHO + Δ → CH(3) + [HCO] → CH(3) + H + CO; elimination: CH(3)CHO + Δ → H(2) + CH(2)=C=O; isomerization∕elimination: CH(3)CHO + Δ → [CH(2)=CH-OH] → HC≡CH + H(2)O. An interesting result is that both PIMS and IR spectroscopy show compelling evidence for the participation of vinylidene, CH(2)=C:, as an intermediate in the decomposition of vinyl alcohol: CH(2)=CH-OH + Δ → [CH(2)=C:] + H(2)O → HC≡CH + H(2)O.
Differential Scanning Calorimeter Based on Suspended Membrane Single Crystal Silicon Microhotplate (2008)

This paper introduces an array of single crystal silicon microhotplates for differential scanning calorimetry. Heat transfer analysis considers the tradeoffs between heating and cooling rate, temperature uniformity, and measurement sensitivity, and determines the optimal design for a suspended membrane microhotplate with full backside release. Additionally, considering the requirements of routine sample loading, the size of the square heater (L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</sub> ) is 100 or 200 mum, while the size of the backside membrane cavity is 400 mum. In the heater region, two interdigitated serpentine doped silicon resistors were designed such that several operational configurations were possible. The hotplates exhibited very high heating efficiency of 36.7 K/mW with L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</sub> = 100 mum and 18.3 K/mW with L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</sub> = 200 mum while also having time constants on the order of 1 ms. Paraffin wax was mounted on the sensor, and melting was observed when the heater temperature was 55degC with a voltage ramp of 0.2 V/s. With 8 V/s, the paraffin sample was completely consumed within 1 ms with 0.317 mJ of thermal energy extracted. Our design achieves a combination of time constant, temperature sensitivity, and heating efficiency that are comparable or superior to previously published microcalorimeters.
ChemInform Abstract: Preparation of meta‐Amidino‐N,N‐disubstituted Anilines as Potent Inhibitors of Coagulation Factor Xa. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Chronic shisha exposure alters phosphoproteome of oral keratinocytes (2019)

Shisha smoking has been epidemiologically linked to oral cancer. However, few studies have investigated the pathobiology of shisha-induced cellular transformation. We studied the effects of chronic shisha exposure (8 months) in an in vitro model using immortalized, non-neoplastic oral keratinocytes (OKF6/TERT1). Quantitative proteomic and phosphoproteomic analyses were performed on OKF6/TERT1 cells treated with shisha extract for a period of 8 months. Pathway analysis was carried out to identify significantly enriched biological processes in shisha-treated cells. Chronic shisha exposure resulted in increased cell scattering phenomenon in OKF6/TERT1 cells. Data analysis revealed differential phosphorylation of 164 peptides (fold change ≥1.5, p ≤ 0.0.5) corresponding to 136 proteins. Proteins associated with mTORC1 and EIF4F complexes involved in initiating protein translation were seen to be enriched upon shisha treatment. Network analysis also highlighted downregulation of proteins involved in Type I interferon signaling in shisha-treated cells. Quantitative phosphoproteomic approach elucidated global perturbations to the molecular milieu of oral keratinocytes upon shisha exposure. Further studies are needed to validate putative targets in oral cancer patients with shisha smoking history.
An orally active small molecule TGF-beta receptor I antagonist inhibits the growth of metastatic murine breast cancer. (2009)

Taken together, the data indicate that the antitumor efficacy of SM16 is dependent on an immune-mediated mechanism and that SM16 may represent a safe and effective treatment for metastatic breast cancer.
Low thermal budgetSiO2∕Si3N4∕SiO2 stacks for advanced SONOS memories (2007)

SiO 2 ∕ Si 3 N 4 ∕ SiO 2 (ONO) stacks are used as trapping media in industrial semiconductor memories. This memory device uses deep traps in the silicon oxynitride interlayer between the silicon nitride layer and the top oxide. In this research, low-thermal budget (low temperature) ONO layers were designed suitable for integration into advanced scaled down semiconductor technologies. The alternative growing procedure included oxidation of silicon nitride surface in oxygen plasma. Low temperature oxidation of the silicon nitride layer in oxygen plasma allows incorporation of oxygen into the silicon nitride layer, thus forming a silicon oxynitride layer. The chemical composition of the silicon oxynitride interlayer was similar to the oxynitride of thermally grown ONO. The plasma procedure did not cause any surface roughening. The memory devices with the low-temperature-oxygen-plasma ONO stack showed similar performance to memories with standard high temperature ONO. ONO structures were characterized chemically and structurally by the time of flight secondary ion mass spectrometry (TOF-SIMS), x-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM).
Simple and Efficient Synthesis of 3,4-Dihydro-2-pyridones via Novel Solid-Supported Aza-Annulation (2000)

A diverse array of 3,4-dihydro-2-pyridones 13 were produced utilizing the unique properties of solid-supported reactions to both drive the reactions to completion and isolate the desired products. The pyridones were synthesized in high purity by a simple sequence of novel steps commencing from an acetophenone-functionalized resin. The para-substituted acetophenone 9 could be anchored to the resin through either a sulfonamide or a carboxamide linkage. The sulfonamide resin 9a, which gave the best results, was treated with several aryl aldehydes and ethoxide to give a variety of chalcones 10a-k in excellent yield (82-99%) upon TFA cleavage. Addition of either methyl or allyl malonate and DBU to 10a-k afforded smoothly the Michael adducts 11a-j (70-99%) which were subsequently cyclized in one step employing acetic acid as a catalyst and several diverse amines to give pure 3,4-dihydro-2-pyridones 13a-p in moderate to excellent yields (30-98%).
Graphene-enhanced plasmonic nanohole arrays for environmental sensing in aqueous samples (2016)

The label-free nature of surface plasmon resonance techniques (SPR) enables a fast, specific, and sensitive analysis of molecular interactions. However, detection of highly diluted concentrations and small molecules is still challenging. It is shown here that in contrast to continuous gold films, gold nanohole arrays can significantly improve the performance of SPR devices in angle-dependent measurement mode, as a signal amplification arises from localized surface plasmons at the nanostructures. This leads consequently to an increased sensing capability of molecules bound to the nanohole array surface. Furthermore, a reduced graphene oxide (rGO) sensor surface was layered over the nanohole array. Reduced graphene oxide is a 2D nanomaterial consisting of sp<sup>2</sup>-hybridized carbon atoms and is an attractive receptor surface for SPR as it omits any bulk phase and therefore allows fast response times. In fact, it was found that nanohole arrays demonstrated a higher shift in the resonance angle of 250-380% compared to a continuous gold film. At the same time the nanohole array structure as characterized by its diameter-to-periodicity ratio had minimal influence on the binding capacity of the sensor surface. As a simple and environmentally highly relevant model, binding of the plasticizer diethyl phthalate (DEP) via π-stacking was monitored on the rGO gold nanohole array realizing a limit of detection of as low as 20 nM. The concentration-dependent signal change was studied with the best performing rGO-modified nanohole arrays. Compared to continuous gold films a diameter-to-periodicity ratio (<i>D</i>/<i>P</i>) of 0.43 lead to a 12-fold signal enhancement. Finally, the effect of environmental waters on the sensor was evaluated using samples from sea, lake and river waters spiked with analytically relevant amounts of DEP during which significant changes in the SPR signal are observed. It is expected that this concept can be successfully transferred to enhance the sensitivity in SPR sensors.
Efficient implementation of the graph-based SLAM on an OMAP processor (2014)

An autonomous robot has to localize itself in an unknown area. Simultaneous Localization and Mapping (SLAM) allows for a robot to build a map of an unknown environment and localize simultaneously itself on this map. Graph-based SLAM methods use a graph to represent and solve the SLAM problem. This paper presents an optimized implementation of the incremental 3D graph-based SLAM on an OMAP architecture used as open multimedia applications platform. This implementation uses an optimized data structure and an efficient memory access management to solve the nonlinear least squares problem related to the algorithm. It takes also advantage of the multi-core architecture to parallelize the algorithm. To evaluate our implementation, we will evaluate the processing times of the implemented algorithm compared to those of the well known framework g <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> o.
Fast word synchronisation for digital pulse-positionmodulation (1999)

A new word synchronisation method for digital pulse-position modulation is proposed which allows faster frame acquisition. Application is intended in high-speed wireless optical communications.
ChemInform Abstract: OPTISCH AKTIVE UEBERGANGSMETALL‐KOMPLEXE 25. MITT. SUBSTITUENTENEINFLUESSE AUF DIE INTRAMOLEKULARE EPIMERISIERUNG VON TETRAGONAL‐PYRAMIDALEN MOLYBDAEN‐ UND WOLFRAM‐KOMPLEXEN (1974)

Abstract Die durch Reaktion von (I) und (II) in siedendem Benzol entstehenden optisch aktiven Diastereomerengemische werden durch fraktionierte Kristallisation in (IIIa) und (IIIb) getrennt.
Artificial hemoprotein nanotubes (2007)

Artificial hemoprotein nanotubes have been prepared by a layer-by-layer deposition technique with human serum albumin (HSA) incorporating the synthetic heme (FeP) [HSA-FeP] using an anodic porous alumina template; each of the liberated tubules has a very uniform outer/inner diameter and can reversibly bind dioxygen (O(2)) at 25 degrees C.