gebhart/patrepeval huggingface dataset:
Gene dose effect reveals no Gs-coupled A2A adenosine receptor reserve in murine T-lymphocytes: studies of cells from A2A-receptor-gene-deficient mice (2001)

Agonist binding to extracellular A2A adenosine receptors (A2ARs) inhibits the activation of virtually all tested functions of T-cells and can induce apoptosis in thymocytes. The evaluation of levels of expression of these immunosuppressive receptors is expected to clarify whether the absence of spare A2ARs (no 'receptor reserve') might be one of the mechanisms of attenuation of the effects of extracellular adenosine on T-cells. A2A transcript is found in T-cells and functional receptors can be demonstrated, but the density of receptor on T-cells is too low to be detected by radioligand binding. Studies of direct radioligand binding to murine brain with the selective A2AR agonist [3H]CGS21680 (2-(4-[(2-carboxyethyl)-phenyl]ethylamino)-5'-N-ethylcarboxamidoadenosine) established that striata levels of A2AR are virtually absent from A2A knock-out mice. Mice that are heterozygous (A2AR+/-) for the A2AR express significantly decreased levels of A2AR. To test for the presence of spare receptors in T-cells we took advantage of this gene dose effect and examined whether the decrease in the number of receptors in thymocytes from A2AR+/- mice was proportionately reflected in a decrease in the functional cAMP response of T-cells to adenosine. cAMP accumulation and apoptosis induced by adenosine and by A2AR agonist are of a lower magnitude in T-cells from A2AR+/- heterozygous mice than in T-cells from A2AR+/+ littermate control mice. These results indicate that there is no A2AR reserve in murine T-cells. Strongly decreased adenosine-triggered cAMP increases were detected in thymocytes from A2AR-/- mice, suggesting that A2B adenosine receptors cannot fully compensate for the loss of A2ARs in murine T-cells. We conclude that the number of A2ARs is the limiting factor in determining the maximal cAMP response of T-lymphocytes to extracellular adenosine, thereby minimizing the immunosuppressive effects of extracellular adenosine.
Gaspard des montagnes (1922)

Roman, d'abord publie en feuilleton dans Le Figaro et en 4 volumes : Le château des sept portes ou Les enfances de (1922), L'auberge de la belle bergere ou Quand Gaspard de guerre revint (1925), Le pavillon des amourettes ou Gaspard et les bourgeois d'Ambert (1930), La Tour du levant ou Quand Gaspard mit fin a l'histoire (1931)
Comparison of the Ca2+ binding properties of the γ‐carboxyglutamic acid‐containing module of protein Z in the intact protein and in N‐terminal fragments (1992)

Protein Z is a vitamin K-dependent plasma protein of unknown function. Its modular structure is identical with those of factors VII, IX, X, and protein C. These proteins have an N-terminal gamma-carboxyglutamic acid (Gla)-containing module which binds six to ten Ca2+. In factors IX, X, and protein C, the adjacent epidermal growth factor (EGF)-like module binds one Ca2+ whereas the EGF-like module in protein Z does not. We have compared the Ca2+ binding properties of a fragment of protein Z comprising the Gla and N-terminal EGF-like modules (pZ-GlaEGFN) with those of intact protein Z and the isolated Gla module by measuring the Ca(2+)-induced quenching of the intrinsic protein fluorescence. The similar Ca2+ affinities of pZ-GlaEGFN and protein Z indicate that pZ-GlaEGFN has a native conformation and normal Ca2+ binding properties. A comparison of the Ca2+ binding to pZ-GlaEGFN with those to the corresponding fragments of factors IX, X, and protein C indicate that Ca2+ binding to the N-terminal EGF-like modules in the latter proteins does not influence the folding and Ca2+ binding properties of their Gla modules. Furthermore, the Ca(2+)-induced fluorescence enhancements of GlaEGF fragments from factors IX, X, and protein C appear to be caused by Ca2+ binding to the site in the EGF-like modules since it is not observed for pZ-GlaEGFN.
The Quill Distributed Analytics Library and Platform (2016)

This technical report introduces Quill (stands for a quadrillion tuples per day), a library and distributed platform for relational and temporal analytics over large datasets in the cloud. Quill exposes a new abstraction for parallel datasets and computation, called ShardedStreamable. This abstraction provides the ability to express efficient distributed physical query plans that are transferable, i.e., movable from offline to real-time and vice versa. ShardedStreamable decouples incremental query logic specification, a small but rich set of data movement operations, and keying; this allows Quill to express a broad space of plans with complex querying functionality, while leveraging existing temporal libraries such as Trill. Quill’s layered architecture provides a careful separation of responsibilities with independently useful components, while retaining high performance. We built Quill for the cloud, with a master-less design where a language-integrated client library directly communicates and coordinates with cloud workers using off-the-shelf distributed cloud components such as queues. Experiments on up to 400 cloud machines, and on datasets up to 1TB, find Quill to incur low overheads and outperform SparkSQL by up to orders-of-magnitude for temporal and 6× for relational queries, while supporting a rich space of transferable, programmable, and expressive distributed physical query plans.
Digitally controlled oscillator in a 65nm GSM/EDGE transceiver with built-in compensation for capacitor mismatches (2011)

A digitally-controlled oscillator (DCO) with a fully-digital compensation mechanism for mismatches in its frequency-tuning capacitor array is proposed. It addresses the inevitable mismatch between the smallest frequency step supported by the integer portion of the frequency-tuning array and the dithering-based fractional portion. Such mismatch results in modulation distortion during transmission and in potential violation of the transmitter's modulation accuracy specifications. The presented solution, which is built-in and relies solely on digital logic and software, is implemented in a 65nm CMOS GSM/EDGE Digital RF Processor (DRP)-based transceiver.
Homogeneity of Grain Refinement of Aluminum Alloy with Compressive Torsion Processing (2007)

Compressive torsion combined loading that uses relatively low compressive pressure has a great advantage of microstructure refinement of cylindrical metal blocks without changing their shape while processing. In the present work, effects of processing temperature and rotation times on homogeneity of the refined microstructure were investigated for Al-5%Mg alloy. Although lower processing temperature was effective to obtain fine grains, it was difficult to obtain homogeneous refinement at lower temperature. Higher processing temperature was favorable to obtain homogeneous microstructure, for instance, in the cylindrical specimen of φ25×10 mm the homogeneous refinement could be obtained at higher temperatures than 373K. Increasing rotation times was also effective to obtain homogeneous refined microstructure for thicker specimens.
Thermogravimetric kinetic analysis of in-situ catalytic pyrolysis of palm oil wastes with the presence of palm oil wastes ash catalyst (2021)

Abstract The thermal degradation and kinetic analysis for oil palm frond (OPF) and oil palm trunk (OPT) with its ashes were investigated using thermogravimetric approach (TGA). OPF ash, OPT ash and its mixtures are used as a natural source of catalysts in the pyrolytic conversion of the palm oil wastes to bioenergy. The TGA experiments were conducted in a range of heating rates of 10-100 K/min from the temperature of 323 K to 1173 K. Coats-Redfern model is applied in this study to evaluate the activation energy ( E A ) and pre-exponential factor ( A ). The average E A values ranged 24.27-32.36 kJ.mol −1 and 41.42-46.10 kJ.mol −1 for pyrolysis of OPF and OPT respectively. Meanwhile, the average E A values ranged 24.27-31.06 kJ.mol −1 and 31.77-43.45 kJ.mol −1 for catalytic pyrolysis of OPF and OPT respectively.
Introduction of New Associate Editors (2016)

Presents a listing of the new Associate Editors for this issue of the publication.
Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells (2013)

Despite the remarkable efficacy of tyrosine kinase inhibitors (TKIs) in eliminating differentiated chronic myeloid leukemia (CML) cells, recent evidence suggests that leukemic stem and progenitor cells (LSPCs) persist long term, which may be partly attributable to cytokine-mediated resistance. We evaluated the expression of the interleukin 3 (IL-3) receptor α subunit (CD123), an established marker of acute myeloid leukemia stem cells, on CML LSPCs and the potential of targeting those cells with the humanized anti-CD123 monoclonal antibody CSL362. Compared with normal donors, CD123 expression was higher in CD34(+)/CD38(-) cells of both chronic phase and blast crisis CML patients, with levels increasing upon disease progression. CSL362 effectively targeted CML LSPCs by selective antibody-dependent cell-mediated cytotoxicity (ADCC)-facilitated lysis of CD123(+) cells and reduced leukemic engraftment in mice. Importantly, not only were healthy donor allogeneic natural killer (NK) cells able to mount an effective CSL362-mediated ADCC response, but so were CML patients' autologous NK cells. In addition, CSL362 also neutralized IL-3-mediated rescue of TKI-induced cell death. Notably, combination of TKI- and CSL362-induced ADCC caused even greater reduction of CML progenitors and further augmented their preferential elimination over normal hematopoietic stem and progenitor cells. Thus, our data support the further evaluation of CSL362 therapy in CML.
Ultralow-Power Bioimpedance IC With Intermediate Frequency Shifting Chopper (2015)

A bioelectrical impedance IC with an intermediate frequency shifting chopper (IFSC) technique driven by a merged clock is presented. The proposed technique enables high-frequency impedance measurements with a narrow bandwidth low-power instrumentation amplifier (IA). The conventional series-connected double choppers required for the frequency shifting operation are replaced with a single chopper driven by a XNOR-merged clock. The proposed IC can measure bioelectrical impedance at a maximum excitation frequency of 1.24 MHz in an IA bandwidth of only 30 kHz. A DC trimming technique that uses a dummy impedance and anti-phase current source can adjust the output offset and prevent output saturation. This DC trimming technique also enables shifting of the impedance measurement scope. The proposed IC is fabricated using 0.13-μm CMOS process, and is shown to achieve a dynamic range of 97.1 dB, and 52 μW of power consumption.
Rationalisation and validation of dc power transfer limits for voltage sourced converter based high voltage DC transmission (2016)

Maximum available power (MAP) is an index for analyzing power‐voltage stability in high‐voltage direct current (HVdc) converters. Earlier work on calculating MAP for voltage sourced converters (VSC) was not consistent with the methods used for line commutated converters (LCC). The Thévenin voltage source used in VSC‐HVdc analysis was set to 1.0 pu, but for LCC‐HVdc, it was calculated so as to provide rated conditions at the converter busbar. This study attempts to rationalize the approaches used for VSC‐HVdc and LCC‐HVdc calculations by making them mutually consistent. However, as the VSC can operate at much lower short‐circuit ratio (SCR) than can the LCC, the Thévenin equivalent voltage at low SCRs can be significantly larger than 1.0 pu. This would require an unreasonably large tap changer setting. As an alternative, the paper recommends that for calculating MAP for a VSC, an ac network equivalent be used where some reactive power is locally supplied by shunt capacitors. This renders a Thévenin voltage close to 1.0 pu. This study also considers the impact of the VSC's internal voltage limits on the MAP. The key results are validated using electromagnetic transients simulation.
System-level evaluation of downlink non-orthogonal multiple access (NOMA) for non-full buffer traffic model (2015)

For the past few years, we proposed non-orthogonal multiple access (NOMA) as a promising multiple access scheme for further improvement of spectrum efficiency for LTE enhancements and the 5th generation mobile communications system (5G). Currently, the system performance of NOMA, considering practical assumptions, different deployment scenarios and NOMA specific functionalities, including multi-user pairing, transmit power allocation, and combination with MIMO is being evaluated and discussed in academia, industry, and standardization [5-16]. In addition, the most of existing evaluations for NOMA focus on the full buffer traffic model, which is widely adopted for the evaluation of mobile radio access system. However, further investigations with non-full buffer traffic model are also important to clarify the system performance of NOMA for different types of the traffic. This paper investigates the system-level performance of NOMA with non-full buffer traffic model for different levels of packet arrival rates and sizes. In addition, the impact of the scheduling algorithm such as α-fair gradient scheduler, which controls the fairness level of the resource allocation, is also discussed. Based on computer simulations, we show that for the non-full buffer case, NOMA can still provide a large performance gain compared to that of orthogonal multiple access (OMA) in particular for small packet sizes. It is also shown that under full buffer traffic model, α-fair gradient scheduler is able to trade-off between average user packet throughput and 5% user packet throughput; however, this does not hold for the case of non-full buffer traffic model.
Pathogenicity and transmission of a swine influenza A(H6N6) virus (2017)

Subtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern China, and since then, it has caused sporadic infections among swine. We show that this virus binds to α2,6-linked and α2,3-linked sialic acids. Mutations at residues 222 (alanine to valine) and 228 (glycine to serine) of the virus hemagglutinin (HA) affected its receptor-binding properties. Experiments showed that the virus has limited transmissibility between ferrets through direct contact or through inhalation of infectious aerosolized droplets. The internal genes of the influenza A(H1N1)pdm09 virus, which is prevalent in swine worldwide, increases the replication efficiency of H6N6 IAV in the lower respiratory tract of ferrets but not its transmissibility between ferrets. These findings suggest H6N6 swine IAV (SIV) currently poses a moderate risk to public health, but its evolution and spread should be closely monitored.
Integrated tandem electroabsorption modulators for high-speed OTDM applications (2002)

An integrated tandem traveling-wave electroabsorption modulators is demonstrated as an optical short pulse generator and demultiplexer for >100 Gbit/s optical time-division-multiplexed systems. Optical pulses of 4.2 ps width at 30 GHz with an extinction ratio in excess of 30 dB are achieved.
Cavity-Enhanced Raman Emission from a Single Color Center in a Solid (2018)

We demonstrate cavity-enhanced Raman emission from a single atomic defect in a solid. Our platform is a single silicon-vacancy center in diamond coupled with a monolithic diamond photonic crystal cavity. The cavity enables an unprecedented frequency tuning range of the Raman emission (100 GHz) that significantly exceeds the spectral inhomogeneity of silicon-vacancy centers in diamond nanostructures. We also show that the cavity selectively suppresses the phonon-induced spontaneous emission that degrades the efficiency of Raman photon generation. Our results pave the way towards photon-mediated many-body interactions between solid-state quantum emitters in a nanophotonic platform.
SERUM INTERLEUKIN-6 LEVELS IN METASTATIC RENAL CELL CARCINOMA BEFORE TREATMENT WITH INTERLEUKIN-2 CORRELATES WITH PARANEOPLASTIC SYNDROMES BUT NOT PATIENT SURVIVAL (1998)

IL-6 was frequently secreted by renal cancer cell lines but it was only present in the serum of approximately half of the patients with metastatic renal cancer. Elevations of serum IL-6 were associated with paraneoplastic manifestations frequently seen in patients with renal cancer, including anemia, thrombocytosis, decreased albumin and elevations of alkaline phosphatase (Stauffer's syndrome). A weak relationship was noted between serum IL-6 level and fever but none was noted between that and survival or response to IL-2.
Enhanced Functional Recovery in MRL/MpJ Mice after Spinal Cord Dorsal Hemisection (2012)

Adult MRL/MpJ mice have been shown to possess unique regeneration capabilities. They are able to heal an ear-punched hole or an injured heart with normal tissue architecture and without scar formation. Here we present functional and histological evidence for enhanced recovery following spinal cord injury (SCI) in MRL/MpJ mice. A control group (C57BL/6 mice) and MRL/MpJ mice underwent a dorsal hemisection at T9 (thoracic vertebra 9). Our data show that MRL/MpJ mice recovered motor function significantly faster and more completely. We observed enhanced regeneration of the corticospinal tract (CST). Furthermore, we observed a reduced astrocytic response and fewer micro-cavities at the injury site, which appear to create a more growth-permissive environment for the injured axons. Our data suggest that the reduced astrocytic response is in part due to a lower lesion-induced increase of cell proliferation post-SCI, and a reduced astrocytic differentiation of the proliferating cells. Interestingly, we also found an increased number of proliferating microglia, which could be involved in the MRL/MpJ spinal cord repair mechanisms. Finally, to evaluate the molecular basis of faster spinal cord repair, we examined the difference in gene expression changes in MRL/MpJ and C57BL/6 mice after SCI. Our microarray data support our histological findings and reveal a transcriptional profile associated with a more efficient spinal cord repair in MRL/MpJ mice.
Ultrasound-Responsive Polymer-Coated Microbubbles That Bind and Protect DNA (2006)

Ultrasound in combination with microbubbles has recently been considered by gene delivery scientists to be an interesting approach to enhance gene transfer into cells. Its low toxicity and simplicity to apply in vivo without major complications make this technology (sonoporation) especially attractive. Sonoporation of DNA has been evaluated in vivo by the injection of free plasmid DNA (pDNA) together with microbubbles (as used in diagnostic imaging) in the bloodstream. However, the in vivo gene-transfer efficiency in these experiments remained rather low. Both the enzymatic degradation of the injected pDNA as well as the low pDNA concentration in the neighborhood of sonoporated cell membranes may explain this low efficiency. Therefore, we developed polymer-coated microbubbles that can bind and protect the pDNA. Coating albumin-shelled microbubbles with poly(allylamine hydrochloride) (PAH) makes the surface charge of the microbubbles positive without drastically affecting the size distribution of the microbubbles, thereby not affecting the ultrasound responsiveness and injectability. The cationic coating allowed both to bind up to 0.1 pg of DNA per microbubble as well as to protect the bound DNA against nucleases. Finally, the PAH coating significantly increased the lifetime of the microbubbles (half-life approximately 7 h), making them more convenient for in vivo applications because more microbubbles are expected to reach the target organ. Binding and nuclease protection of DNA by polymer-coated diagnostic microbubbles has, to our knowledge, never been demonstrated. We conclude that these LbL-coated microbubbles might be significant in the further development of ultrasound-mediated gene delivery.
DESYNCHRONIZATION AND DECOUPLING OF INTERACTING OSCILLATORS BY NONLINEAR DELAYED FEEDBACK (2006)

A novel control method for desynchronization of strongly synchronized populations of interacting oscillators is described. We show that an ensemble's mean field, nonlinearly processed and fed back into the ensemble, causes an effective desynchronization. The method is mild, demand controlled, and robust against system and stimulation parameter variations. The desynchronization and decoupling effects of the method are illustrated by examples of one and two interacting populations of limit-cycle oscillators. We suggest our method for mild and effective deep brain stimulation in neurological diseases characterized by pathological cerebral synchronization.
WHAT “DOSE” OF OXYGEN IS REQUIRED IN TREATING PROLONGED CARDIAC ARREST (1995)

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032.
A simplified opportunistic feedback and scheduling scheme for OFDM (2005)

Opportunistic beamforming schedules users when they experience a high instantaneous signal-to-noise ratio. Multiple antennas at the transmitter can he used to induce temporal fading to ensure that all users fade at a rate fast enough to ensure fairness. Because feedback is required, the fading rate must be fast enough to ensure fairness among users, but slow enough so that the feedback information is not out of date. An OFDM system with opportunistic beamforming has the advantage that multiple users can be scheduled at the same time in a frequency-selective channel, thus allowing a slower fading rate. However, the overhead cost of feeding back every sub-carrier for every user is very high. We propose a simplified opportunistic feedback scheme that divides the OFDM symbol into clusters. Each user feeds back a figure-of-merit listing its strongest clusters. This scheme greatly reduces the feedback overhead, without sacrificing performance significantly. In addition, the scheme has an inherent on/off waterfilling property. We compare this simplified feedback scheme in a HIPERLAN/2 scenario to a feeding back of all subcarriers and also to a smart antenna system and show that, when there are many users, it outperforms the smart antenna system.
Enhanced Mechanical Properties and Anti–Inflammation of Poly(L–Lactic Acid) by Stereocomplexes of PLLA/PDLA and Surface–Modified Magnesium Hydroxide Nanoparticles (2022)

Poly(L-lactic acid) (PLLA), as a biodegradable polymer, has attracted attention for use as a biomaterial. In order to apply PLLA as a cardiovascular stent, stronger mechanical properties and anti-inflammatory effects against acidic by-products are required. In this study, PLLA/PDLA stereocomplex microparticles (SC) were developed and surface-modified magnesium hydroxide (MH) nanoparticles with oligolactide were combined with these PLLA composites. The SC improved the mechanical properties of the PLLA composites through the formation of stereocomplex structures. The surface-modified MH nanoparticles showed enhanced mechanical properties due to the stereocomplex structures formed by PLLA chains and inhibited inflammatory responses by pH neutralization as a result of MH. Additionally, the MH nanoparticles containing PLLA composites had antibacterial effects and increased the viability of human vascular endothelial cells. This technology is expected to have great potential in the development of PLLA composite materials for the production of various medical devices, such as cardiovascular stents.