gebhart/patrepeval huggingface dataset:
Syntheses of heterocyclic compounds. 509. Syntheses of analgesics. 34. Synthesis of 3-hydroxy-N-cyclopropylmethyl-9-azamorphinan (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses of heterocyclic compounds. 509. Syntheses of analgesics. 34. Synthesis of 3-hydroxy-N-cyclopropylmethyl-9-azamorphinanTetsuji Kametani, Kazuo Kigasawa, Mineharu Hiiragi, Nagatoshi Wagatsuma, Tsuneo Uryu, and Kunio ArakiCite this: J. Med. Chem. 1973, 16, 3, 301–303Publication Date (Print):March 1, 1973Publication History Published online1 May 2002Published inissue 1 March 1973https://pubs.acs.org/doi/10.1021/jm00261a035https://doi.org/10.1021/jm00261a035research-articleACS PublicationsRequest reuse permissionsArticle Views86Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Public-Key Cryptosystems with Very Small Key (1993)

In some applications of public-key cryptography it is desir- able, and perhaps even necessary, that the key size be as small as possi- ble. Moreover, the cryptosystem just needs to be secure enough so that brcaking it is not cost-effective. Tlic pu~pusc or llLis paper is lu hives- tigate the security and practicality of elliptic curve cryptosystems with small key sizes of about 100 bits.
Electroactive nanoparticle directed assembly of functionalized graphene nanosheets into hierarchical structures with hybrid compositions for flexible supercapacitors (2013)

Hierarchical structures of hybrid materials with the controlled compositions have been shown to offer a breakthrough for energy storage and conversion. Here, we report the integrative assembly of chemically modified graphene (CMG) building blocks into hierarchical complex structures with the hybrid composition for high performance flexible pseudocapacitors. The formation mechanism of hierarchical CMG/Nafion/RuO2 (CMGNR) microspheres, which is triggered by the cooperative interplay during the in situ synthesis of RuO2 nanoparticles (NPs), was extensively investigated. In particular, the hierarchical CMGNR microspheres consisting of the aggregates of CMG/Nafion (CMGN) nanosheets and RuO2 NPs provided large surface area and facile ion accessibility to storage sites, while the interconnected nanosheets offered continuous electron pathways and mechanical integrity. The synergistic effect of CMGNR hybrids on the supercapacitor (SC) performance was derived from the hybrid composition of pseudocapacitive RuO2 NPs with the conductive CMGNs as well as from structural features. Consequently, the CMGNR-SCs showed a specific capacitance as high as 160 F g(-1), three-fold higher than that of conventional graphene SCs, and a capacitance retention of >95% of the maximum value even after severe bending and 1000 charge-discharge tests due to the structural and compositional features.
N2O Removal by Catalytic Decomposition and Reduction with CH4 over Fe/Al2O3 (2003)

Abstract N2O removal by catalytic decomposition and reduction with CH4 over Fe/Al2O3 was investigated. The catalytic conversion of N2O to N2 over Fe/Al2O3 was effectively promoted by the addition of CH4. The activity of Fe/Al2O3 normalized on a TOF basis for N2O decomposition increased linearly with the Fe loading, whereas that for N2O reduction increased with an increase in Fe loading up to 2 wt %, then subsequently decreased. Structural characterization by UV–vis and TPR revealed the presence of two types of Fe species, Fe2O3 and FeAlO3, in Fe/Al2O3. It was proposed that the catalytically active species for N2O decomposition and N2O reduction are Fe2O3 and FeAlO3, respectively.
Interventional dual‐energy imaging—Feasibility of rapid kV‐switching on a C‐arm CT system (2016)

The feasibility of dual-energy imaging using a fast kV-switching method on an angiographic C-arm CT system was investigated. Direct measurements of beam quality in the x-ray field demonstrate the stability of the kV-switching method. Phantom and in vivo experiments showed that images did not deviate from those of corresponding kV-constant scans. All performed experiments confirmed the capability of performing fast kV-switching scans on a clinically available C-arm CT system. More complex material decomposition tasks and postprocessing steps will be part of future investigations.
A case of Carney triad complicated by renal cell carcinoma and a germline SDHA pathogenic variant (2021)

The succinate dehydrogenase enzyme is encoded by four subunit genes (SDHA, SDHB, SDHC, and SDHD; collectively referred to as SDHx), which have been implicated in several neoplasias and are classified as tumor suppressor genes. Carney triad is a rare multiple-neoplasia syndrome presenting as an association of PGLs, GISTs, and CHOs. Carney triad is most commonly associated with hypermethylation of SDHC as demonstrated in tumor tissue, but approximately 10% of cases are due to pathogenic SDHx variants. Although SDHB pathogenic variants are most commonly reported in SDH-deficient renal cell carcinoma, SDHA disease-causing variants have been reported in rare cases.
The Protective Effect of Cynara Cardunculus Extract in Diet-Induced NAFLD: Involvement of OCTN1 and OCTN2 Transporter Subfamily (2020)

<b>Hyperlipidemia</b> and insulin-resistance are often associated with Non-Alcoholic Fatty Liver Disease (NAFLD) thereby representing a true issue worldwide due to increased risk of developing cardiovascular and systemic disorders. Although clear evidence suggests that circulating fatty acids contribute to pathophysiological mechanisms underlying NAFLD and hyperlipidemia, further studies are required to better identify potential beneficial approaches for counteracting such a disease. Recently, several artichoke extracts have been used for both reducing hyperlipidemia, insulin-resistance and NAFLD, though the mechanism is unclear. Here we used a wild type of Cynara Cardunculus extract (CyC), rich in sesquiterpens and antioxidant active ingredients, in rats fed a High Fat Diet (HFD) compared to a Normal Fat Diet (NFD). In particular, in rats fed HFD for four consecutive weeks, we found a significant increase of serum cholesterol, triglyceride and serum glucose. This effect was accompanied by increased body weight and by histopathological features of liver steatosis. The alterations of metabolic parameters found in HFDs were antagonised dose-dependently by daily oral supplementation of rats with CyC 10 and 20 mg/kg over four weeks, an effect associated to significant improvement of liver steatosis. The effect of CyC (20 mg/kg) was also associated to enhanced expression of both OCTN1 and OCTN2 carnitine-linked transporters. Thus, present data suggest a contribution of carnitine system in the protective effect of CyC in diet-induced hyperlipidemia, insulin-resistance and NAFLD.
RADI-11. NRG ONCOLOGY CC001: A PHASE III TRIAL OF HIPPOCAMPAL AVOIDANCE IN ADDITION TO WHOLE-BRAIN RADIOTHERAPY (WBRT) PLUS MEMANTINE TO PRESERVE NEUROCOGNITIVE FUNCTION IN PATIENTS WITH BRAIN METASTASES (BM) (2019)

Abstract BACKGROUND: NRG CC001, a phase III trial of WBRT+memantine (WBRT+M) with or without Hippocampal Avoidance (HA), sought to assess the neuro-protective effects of lowering the radiation dose received by the hippocampus. METHODS: Patients (pts) with brain metastases were stratified by RPA class and prior radiosurgery/surgery and randomized to either WBRT+M or HA-WBRT+M (30Gy/10 fractions). Standardized neurocognitive function (NCF) tests were performed at baseline, 2, 4, 6, and 12 months (mos.). The primary endpoint was NCF failure, defined as decline using the reliable change index on Hopkins Verbal Learning Test-Revised, Trail Making Test, or Controlled Oral Word Association. Cumulative incidence estimated NCF failure (death without NCF failure was competing risk); between-arms differences tested using Gray’s test. Deterioration at each collection time point was tested using a chi-square test. Patient-reported symptoms were assessed using the MD Anderson Symptom Inventory with Brain Tumor module and analyzed using mixed effects models and t-tests. RESULTS: From 7/2016 to 3/2018, 518 patients were randomized. Median follow-up was 7.9 mos. HA-WBRT+M was associated with lower NCF failure risk (adjusted HR=0.74, p=0.02) due to lower risk of deterioration in executive function at 4 mos. (p=0.01); and encoding (p=0.049) and consolidation (p=0.02) at 6 mos. Age≤61 predicted for lower NCF failure risk (HR=0.60, p=0.0002); non-significant test for interaction indicated independent effects of HA and age. Patient-reported fatigue (p=0.036); difficulty speaking (p=0.049); and problems remembering things (p=0.013) at 6 mos. favored the HA-WBRT+M arm. Imputation models accounting for missing data also favored the HA-WBRT+M arm for patient-reported cognition (p=0.011) and symptom interference (p=0.008) at 6 mos. Treatment arms did not significantly differ in toxicity; intracranial progression or overall survival. CONCLUSIONS: While achieving similar intracranial control and survival; Hippocampal Avoidance during WBRT+M for brain metastases better preserves NCF and patient-reported symptoms. Supported by UG1CA189867 (NCORP) and DCP from the NCI.
Sterility and Pyrogenicity Issues of Synthetic Vascular Grafts (1986)

Common sterilization techniques, validation methods, and the physical and biologic effects of sterilization on synthetic vascular graft materials are reviewed. Pyrogenicity issues are discussed. A series of endotoxin-contaminated polyester externally supported grafts were tested in a canine model to assess the clinical significance of pyrogen contamination. Systemic pyrogenicity was observed, but gross thrombus formation was unaffected. The pathogenesis of graft infections are then reviewed.
Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes (1999)

The TCL1 oncogene on human chromosome 14q32.1 is involved in the development of T cell leukemia in humans. Its expression in these leukemias is activated by chromosomal translocations and inversions at 14q32.1. Here we report the isolation and characterization of a new member of the TCL1 gene family, TCL1b, located approximately 16 kb centromeric of TCL1. The 1.2-kb TCL1b cDNA encodes a 14-kDa protein of 128 aa and shows 60% similarity to Tcl1. Expression profiles of TCL1 and TCL1b genes are very similar: both genes are expressed at very low levels in normal bone marrow and peripheral lymphocytes but are activated in T cell leukemia by rearrangements of the 14q32.1 region. Thus, translocations and inversions at 14q32. 1 in T cell malignancies involve two oncogenes.
An Open-Source Archiving System (2011)

Establishment of a Web-based repository for wireless multipath channel measurement data would make it possible for the researchers to pool their datasets to yield more reliable or broadly applicable results or to extract additional value from data that may have been collected for other purposes. It would also allow the validity of models derived from certain data sets to be more easily tested against other data sets than at present. Moreover, ongoing developments in Web technologies will greatly add to the capabilities of such repositories in the coming years. While the wireless community would greatly benefit from the establishment of such a repository for channel measurement data, account must be taken of the significant differences between wireless channel-response data and data collected in other scientific fields. A particu ar challenge is to ensure that essential details concerning the measurement equipment used to collect the data, the manner in which the equipment was calibrated and verified, the data collection procedure, and details of the environment in which the data were collected are adequately documented and linked to the channel response data. Nevertheless, it seems likely that the return from such a wireless channel-response data repository would justify the effort required to set up and maintain it.
VUV Photoelectron Spectroscopy of Cysteine Aqueous Aerosols: A Microscopic View of Its Nucleophilicity at Varying pH Conditions (2015)

Cysteine (Cys) is unique due to its highly reactive thiol group. It often regulates the biological function of proteins by acting as the redox site. Despite its biological significance, however, the valence electronic structure of Cys under the aqueous environments remains unavailable. Here, we report the VUV photoelectron spectroscopy of Cys aqueous aerosols via a newly built aerosol VUV photoelectron spectroscopy apparatus. The photoelectron spectra of Cys show distinct band shapes at varying pH conditions, reflecting the altered molecular orbital characters when its dominating form changes. The ionization energy of Cys is determined to be 8.98 ± 0.05 eV at low pH. A new feature at a binding energy of 6.97 ± 0.05 eV is observed at high pH, suggesting that the negative charge on the thiolate group becomes the first electron to be removed upon ionization. This work implies that when Cys is involved in redox processes, the charge transfer mechanism may be entirely altered under different pH conditions.
Pyrazolato-Bridged Dinuclear Complexes of Ruthenium(II) and Rhodium(III) with N-Heterocyclic Carbene Ligands: Synthesis, Characterization, and Electrochemical Properties (2013)

Pyrazolato-bridged dinuclear complexes of ruthenium and rhodium were synthesized from N-heterocyclic carbene (NHC) precursors, 3,5-bis[(methylimidazolium-1-yl)methyl]-1H-pyrazole bis(hexafluorophosphate), and the metal precursors [Ru(p-cymene)Cl2]2 and [Rh(η5-C5Me5)Cl2]2. Depending on the reaction conditions, dinuclear bis(imidazolium) complexes or the corresponding bis(NHC) complexes were formed. These complexes were characterized by NMR spectroscopy, elemental analysis, and single-crystal X-ray diffraction. The metal–metal distances are in the range 3.85–3.92 Å. Accordingly, a metal–metal bond can be excluded in all cases. The electronic properties were examined by cyclic voltammetry (CV) to detect possible electronic coupling between the metal centers. In the case of the imidazolium complexes irreversible processes are observed in CV, indicating decomposition. The Ru–bis(NHC) complex—coordinatively saturated with six acetonitrile molecules instead of p-cymene ligands—shows three reversible redox processes. Density functional theory (DFT) calculations were used to verify the processes during CV. The Rh–bis(NHC) complex decomposes through irreversible reductions.
Buckling and kinking force measurements on individual multiwalled carbon nanotubes (2007)

Using an atomic force microscope operated inside a transmission electron microscope, we have studied the forces involved in buckling and kinking an individual multiwalled carbon nanotube while observing its structure. In particular, we have measured an individual nanotube's asymptotic critical buckling load and critical kinking load. The buckling results are well described by classical elastic theory, while the observed kinking behavior requires a more involved analysis. Repeated buckling measurements on the same nanotube indicate an extremely high degree of elasticity and set a lower bound on the nanotube's yield strength of $1.7\phantom{\rule{0.3em}{0ex}}\mathrm{GPa}$, higher than the yield strength of steel. Plastic deformation of the nanotube was eventually observed following kinking.
MPC-based yaw and lateral stabilisation via active front steering and braking (2008)

In this paper, we propose a path following Model Predictive Control-based (MPC) scheme utilising steering and braking. The control objective is to track a desired path for obstacle avoidance manoeuvre, by a combined use of braking and steering. The proposed control scheme relies on the Nonlinear MPC (NMPC) formulation we used in [F. Borrelli, et al., MPC-based approach to active steering for autonomous vehicle systems, Int. J. Veh. Autonomous Syst. 3(2/3/4) (2005), pp. 265–291.] and [P. Falcone, et al., Predictive active steering control for autonomous vehicle systems, IEEE Trans. Control Syst. Technol. 15(3) (2007), pp. 566–580.]. In this work, the NMPC formulation will be used in order to derive two different approaches. The first relies on a full tenth-order vehicle model and has high computational burden. The second approach is based on a simplified bicycle model and has a lower computational complexity compared to the first. The effectiveness of the proposed approaches is demonstrated through simulations and experiments.
ETV2/ER71 regulates the generation of FLK1+ cells from mouse embryonic stem cells through miR-126-MAPK signaling (2019)

Previous studies including ours have demonstrated a critical function of the transcription factor ETV2 (ets variant 2; also known as ER71) in determining the fate of cardiovascular lineage development. However, the underlying mechanisms of ETV2 function remain largely unknown. In this study, we demonstrated the novel function of the miR (micro RNA)-126-MAPK (mitogen-activated protein kinase) pathway in ETV2-mediated FLK1 (fetal liver kinase 1; also known as VEGFR2)<sup>+</sup> cell generation from the mouse embryonic stem cells (mESCs). By performing a series of experiments including miRNA sequencing and ChIP (chromatin immunoprecipitation)-PCR, we found that miR-126 is directly induced by ETV2. Further, we identified that miR-126 can positively regulate the generation of FLK1<sup>+</sup> cells by activating the MAPK pathway through targeting SPRED1 (sprouty-related EVH1 domain containing 1). Further, we showed evidence that JUN/FOS activate the enhancer region of FLK1 through AP1 (activator protein 1) binding sequences. Our findings provide insight into the novel molecular mechanisms of ETV2 function in regulating cardiovascular lineage development from mESCs.
Nested Metamaterials for Wireless Strain Sensing (2010)

We designed, fabricated, and characterized metamaterial-based RF-microelectromechanical system (RF-MEMS) strain sensors that incorporate multiple split ring resonators (SRRs) in a compact nested architecture to measure strain telemetrically. We also showed biocompatibility of these strain sensors in an animal model. With these devices, our bioimplantable wireless metamaterial sensors are intended, to enable clinicians, to quantitatively evaluate the progression of long-bone fracture healing by monitoring the strain on the implantable fracture fixation hardware in real time. In operation, the transmission spectrum of the metamaterial sensor attached to the implantable fixture is changed when an external load is applied to the fixture, and from this change, the strain is recorded remotely. By employing telemetric characterizations, we reduced the operating frequency and enhanced the sensitivity of our novel nested SRR architecture compared to the conventional SRR structure. The nested SRR structure exhibited a higher sensitivity of 1.09 kHz/kgf operating at lower frequency compared to the classical SRR that demonstrated a sensitivity of 0.72 kHz/kgf. Using soft tissue medium, we achieved the best sensitivity level of 4.00 kHz/kgf with our nested SRR sensor. Ultimately, the laboratory characterization and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in vivo</i> biocompatibility studies support further development and characterization of a fracture healing system based on implantable nested SRR.
Characterization of Boron-Doped Diamond Epitaxial Films (1991)

Boron-doped diamond epitaxial films were characterized on the dependence of boron concentration by an optical microscope, reflection high-energy electron diffraction, secondary ion mass spectrometry, Hall effect measurement and metal contacts. These films were grown on synthesized single-crystal diamonds(100) by microwave plasma chemical vapor deposition (CVD) using H 2 , CH 4 and B 2 H 6 at a CH 4 concentration of CH 4 /H 2 =6% and at doping gas ratios of B 2 H 6 /CH 4 =0.83 ppm, 8.3 ppm, and 167 ppm. They were all epitaxially grown and had smooth surfaces. Hall effect measurements were performed in the temperature range of 300 K to 773 K. They indicated that there existed acceptorlike centers other than boron in the films synthesized in the vapor phase. Fermi degeneracy was found to occur at a boron concentration of 3×10 20 cm -3 . Schottky diodes were fabricated using Al for Schottky contacts and Ti for ohmic contacts. Rectifying properties were degraded at high boron concentration.
<title>Experimental demonstration of a two-stage binary optical time delay system</title> (1996)

The features and operation of an electro-optically switched binary optical time delay system are discussed. THe system based on polarization switching using the low cost ferro- electric liquid crystal and polarizing beam splitters provides compactness, low complexity, low insertion loss and arbitrary time delay. We present the design, component selection, fabrication, testing, and evaluation of a prototype.
Template Synthesis of Decaphyrin without Meso-Bridges: Cyclo[10]pyrrole (2016)

An acenaphthylene-fused cyclo[10]pyrrole 1b was selectively synthesized via an oxidative coupling reaction of the corresponding 2,2'-bipyrrole with the appropriate dianion template, croconate anion. The structure of 1b as the isolated largest cyclo[n]pyrrole was elucidated by X-ray crystallographic analysis. The absorption spectrum exhibited a markedly red-shifted, intensified L band at 1982 nm, which was interpreted by application of Michl's perimeter and Gouterman's 4-orbital models, supported by magnetic circular dichroism (MCD) data and theoretical calculations.
Electrical actuation and readout in a nanoelectromechanical resonator based on a laterally suspended zinc oxide nanowire (2011)

In this paper, we present experimental results describing enhanced readout of the vibratory response of a doubly clamped zinc oxide (ZnO) nanowire employing a purely electrical actuation and detection scheme. The measured response suggests that the piezoelectric and semiconducting properties of ZnO effectively enhance the motional current for electromechanical transduction. For a doubly clamped ZnO nanowire resonator with radius ~10 nm and length ~1.91 µm, a resonant frequency around 21.4 MHz is observed with a quality factor (Q) of ~358 in vacuum. A comparison with the Q obtained in air (~242) shows that these nano-scale devices may be operated in fluid as viscous damping is less significant at these length scales. Additionally, the suspended nanowire bridges show field effect transistor (FET) characteristics when the underlying silicon substrate is used as a gate electrode or using a lithographically patterned in-plane gate electrode. Moreover, the Young's modulus of ZnO nanowires is extracted from a static bending test performed on a nanowire cantilever using an AFM and the value is compared to that obtained from resonant frequency measurements of electrically addressed clamped–clamped beam nanowire resonators.
Supplementary Table S10 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers (2023)

&lt;p&gt;HPV abundance scores TCGA.&lt;/p&gt;