gebhart/patrepeval huggingface dataset:
Identification and characterization of a molecule, BAM11, that associates with the pleckstrin homology domain of mouse Btk (2000)

Bruton's tyrosine kinase (Btk) is required for normal B cell development and signal transduction through cell surface molecules, and its defects lead to X-linked immune deficiency in mice and X-linked agammaglobulinemia in humans. In this report, we will describe the identification and characterization of a molecule, BAM11, which binds to the pleckstrin homology domain of Btk. A sequence homology search revealed that BAM11 has 89% homology, at the amino acid level, to human LTG19/ENL, that was originally identified as one of the fusion partners involved in chromosomal translocations of 11q23, MLL/ALL-1/HRX, in leukemia cells. Deletion mutants demonstrated that the region of BAM11 required for binding to Btk was localized between amino acid residues 240 and 256. Forced expression of a truncated form of BAM11 (amino acids 246-368) inhibited IL-5-induced proliferation by 50%, whereas forced expression of full-length BAM11 in Y16 cells did not affect the IL-5 responsiveness. We have also shown that BAM11 (amino acids 246-368) inhibited the kinase activity of Btk. These results suggest that the binding of BAM11 to Btk plays a regulatory role in the Btk signal transduction pathway. A cell fractionation study and analysis using EGFP-fused Btk protein demonstrated that a proportion of Btk is present within the nucleus.
Rule based algorithm for Plug-in Hybrid Electric Vehicles (PHEVs) integration in residential electric grid areas (2012)

The Plug-in Hybrid Electric Vehicles (PHEVs) will strongly penetrate in the car fleet for the coming years. Based on databases of the houses Daily Loads Profiles (DLPs) build from real electricity consumption of domestic's electrical devices, this paper determines the minimal load power of PHEVs which assures the complete recharge of batteries before the next reuse of vehicles while avoiding recharging during the peak hours. A Rule Based algorithm is developed which allows to PHEVs constructors to limit PHEVs charging current to 8A if they are charged at home. In match with different levels of the load powers existing in France, we recommend a maximum load power chargers for PHEVs charged in residential electric grid areas equals to 1840W (230V×8A) which ensures that 100% of the PHEVs batteries have a State of Charge (SOC) equals to 100% for the next use.
Ordered alloying of Pd with the Mo(100) Surface (2000)

The interaction of Pd with the Mo(100) surface has been studied with low-energy electron microscopy and diffraction, and first-principles total-energy calculations. Deposition of Pd at elevated temperature leads initially to the development of an intense $c(2\ifmmode\times\else\texttimes\fi{}2)$ diffraction pattern. Theoretical calculations demonstrate that a $c(2\ifmmode\times\else\texttimes\fi{}2)$ substitutional alloy is energetically favored compared to an overlayer structure at half monolayer coverage. The creation of a large number of islands upon Pd deposition is consistent with the formation of a substitutional alloy. Accommodation of Pd in excess of the ideal $c(2\ifmmode\times\else\texttimes\fi{}2)$ coverage leads to the formation of a $c(2\ifmmode\times\else\texttimes\fi{}n)$ structure $(n=8,10),$ although with little apparent further change of surface morphology. Proliferation of antiphase domain walls in the $c(2\ifmmode\times\else\texttimes\fi{}2)$ alloy is proposed to explain the $c(2\ifmmode\times\else\texttimes\fi{}n)$ periodic structure. Theoretical calculations indicate that a pseudomorphic Pd overlayer is the most stable configuration at 1 monolayer coverage, and that the Pd-covered Mo(100) surface may become unstable with respect to faceting to the {112} orientations if pseudomorphic growth can be realized up to 2 monolayer coverage. However, the $c(2\ifmmode\times\else\texttimes\fi{}n)$ structure is found experimentally to be stable at the interface between Mo and thicker Pd overlayers. These results suggest that there is a kinetic limitation to the formation of the pseudomorphic structure and the faceting instability is preempted by the formation of more complex surface alloy structures.
ChemInform Abstract: Two‐Photon Absorption and Second Hyperpolarizability Measurements in Diphenylbutadiene by Degenerate Four‐Wave Mixing. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Climate Crisis and Cultural Studies (2022)

기후위기의 심각성을 규명하고 대안을 제시하는 과학적 · 정책적 연구가 누적되고 ‘인류세’와 ‘자본세’ 같은 경고성 담론들도 세계적으로 확산되고 있다. 하지만 정작 기후위기의 주범인 자본과 국가는 책임을 회피할 뿐만 아니라 문제를 계속 악화시키고 있다. 이런 악순환에서 벗어나려면 기후위기의 직접 피해자인 대중 스스로 소비자본주의적인 생활문화의 패턴을 크게 바꾸어야 할 것이다. 이 글에서는 기후위기와 경제적 · 정치적 변화와 시민들의 일상생활 변화의 관계를 레이먼드 윌리엄스의 ‘자연적 성장의 육성으로서의 문화’ 개념을 통해 새롭게 조명해 보고, 에너지-소비 감축의 불편함과 고통을 새로운 형태의 즐거움과 보람으로 상쇄할 수 있는 문화적 실천이 어떤 것일지 살피려고 한다. 기후위기를 촉진하는 부와 권력의 축적이 아니라 적은 에너지를 사용하면서도 인간의 자연에 내재한 다중지능 역량들을 활성화하는 문화적 실천이 그것이다. 아래로부터 이런 실천들의 누적 없이는 자연을 파괴하는 문명에서 자연과 공진화하는 새로운 문명으로의 전환은 불가능할 것이다.
Mechanistic studies of the reduction of Rhus vernicifera laccase by hydroquinone (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanistic studies of the reduction of Rhus vernicifera laccase by hydroquinoneRobert A. Holwerda and Harry B. GrayCite this: J. Am. Chem. Soc. 1974, 96, 19, 6008–6022Publication Date (Print):September 1, 1974Publication History Published online1 May 2002Published inissue 1 September 1974https://pubs.acs.org/doi/10.1021/ja00826a009https://doi.org/10.1021/ja00826a009research-articleACS PublicationsRequest reuse permissionsArticle Views257Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Low-voltage and high-speed switching of a magnetoelectric element for energy efficient compute (2022)

150 mV voltage-driven switching of a ferromagnet (FM) exchange-coupled to 6-nm-thick lanthanum-doped BiFeO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> (LBFO) was demonstrated at room temperature (RT). Further, less than 2 ns 0%-90% switching of LBFO ferroelectric polarization was demonstrated through real-time oscilloscope measurements. These two results are respectively the lowest voltage magnetoelectric switching and the highest switching speed measured in LBFO, enabled by high quality epitaxial growth of ultra-thin LBFO/FM films. These results are key accomplishments for energy efficient computing as has been shown through circuit-level simulations of the magnetoelectric random access memory (ME-RAM) utilizing compact models calibrated to the experiments in this work.
Correlations Between Global Clotting Function Tests, Duration of Operation, and Postoperative Chest Tube Drainage in Pediatric Cardiac Surgery (2012)

Hayashi, Tamaki*; Sakurai, Yoshihiko*; Fukuda, Kazuyoshi*; Yada, Koji*; Ogiwara, Kenichi*; Matsumoto, Tomoko*; Yoshizawa, Hiroyuki*; Takahashi, Yukihiro†; Yoshikawa, Yoshiro‡; Hayata, Yoshihiro‡; Taniguchi, Shigeki†; Shima, Midori*Author Information
Pain management and opioid stewardship in adult cardiac surgery: Joint consensus report of the PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Society (2023)

Based on the available literature and expert consensus, there is an opportunity to optimize anesthesia and analgesia for cardiac surgery patients. Although additional research is needed to establish specific strategies, core principles of pain management and opioid stewardship apply to the cardiac surgery population.
Simultaneous power supply, threshold voltage, and transistor size optimization for low-power operation of CMOS circuits (1998)

This paper demonstrates a new approach for minimizing the total of the static and the dynamic power dissipation components in a complementary metal-oxide-semiconductor (CMOS) logic network required to operate at a specified clock frequency. The algorithms presented can be used to design ultralow-power CMOS logic circuits by joint optimization of supply voltage, threshold voltage and device widths. The static, dynamic and short-circuit energy components are considered and an efficient heuristic is developed that delivers over an order of magnitude savings in power over conventional optimization methods.
DL-Based LV Volume Segmentation to Compare Respiratory-Corrected and 4D XD-GRASP Respiratory Motion-Resolved Whole-Heart Reconstructions (2023)

Rapid and accurate quantification of left ventricular volume is essential for studying cardiac function. In this work, two reconstruction techniques for free-breathing, ECG-gated, radial, golden-angle phyllotaxis acquisition of whole-heart CMR are assessed for their accuracy in quantifying left ventricular volume using deep learning (DL)-based automatic cardiac chamber segmentation. The off-line reconstruction that resolves 4D (3D+respiratory) images had better agreement between the DL-based segmentation and an expert&amp;rsquo;s manual segmentation than the in-line reconstruction that corrects for respiratory motion, as assessed by the average volume difference (p=0.026) and 3D Dice coefficients (p=0.032).
Decreased Dopamine D2 Receptor Binding in the Anterior Cingulate Cortex in Schizophrenia (2002)

The lower BP values indicate fewer D2 receptors in the anterior cingulate cortex in patients with schizophrenia. Alterations in D2 receptor function in the extrastriatal region may underlie the positive symptoms of schizophrenia.
Diverging Alternative Splicing Fingerprints in the Transforming Growth Factor-β Signaling Pathway Identified in Thoracic Aortic Aneurysms (2011)

Impaired regulation of the transforming growth factor-β (TGFβ) signaling pathway has been linked to thoracic aortic aneurysm (TAA). Previous work has indicated that differential splicing is a common phenomenon, potentially influencing the function of proteins. In the present study we investigated the occurrence of differential splicing in the TGFβ pathway associated with TAA in patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV). Affymetrix human exon arrays were applied to 81 intima/media tissue samples from dilated (n = 51) and nondilated (n = 30) aortas of TAV and BAV patients. To analyze the occurrence of alternative splicing in the TGFβ pathway, multivariate techniques, including principal component analysis and OPLS-DA (orthogonal partial least squares to latent structures discriminant analysis), were applied on all exons (n = 614) of the TGFβ pathway. The scores plot, based on the splice index of individual exons, showed separate clusters of patients with both dilated and nondilated aorta, thereby illustrating the potential importance of alternative splicing in TAA. In total, differential splicing was detected in 187 exons. Furthermore, the pattern of alternative splicing is clearly differs between TAV and BAV patients. Differential splicing was specific for BAV and TAV patients in 40 and 86 exons, respectively, and splicings of 61 exons were shared between the two phenotypes. The occurrence of differential splicing was demonstrated in selected genes by reverse transcription-polymerase chain reaction. In summary, alternative splicing is a common feature of TAA formation. Our results suggest that dilatation in TAV and BAV patients has different alternative splicing fingerprints in the TGFβ pathway.
The immunologic and clinicopathologic heterogeneity of cutaneous lymphomas other than mycosis fungoides (1983)

Twenty-one cases of non-Hodgkin's lymphoma with cutaneous involvement, other than mycosis fungoides, were evaluated immunologically, histologically, and clinically. Ten patients presented with skin disease alone, seven with concurrent cutaneous and extracutaneous disease, and four with extracutaneous disease only. Twenty of the 21 cases were nonepidermotropic tumors and were equally likely to express B or T phenotypes. None of the cases expressed a true histiocytic phenotype. Almost all cases expressed la and class 1 HLA determinants. Immunophenotypes were stable regardless of time interval, therapy, or body site sampled in seven of eight patients studied serially. In contrast to mycosis fungoides, the T lymphomas exhibited noncerebriform cytology, tumor la expression, lack of mature helper T-cell phenotype, nonepidermotropic histology, a tendency for marrow involvement, and presented as nodules rather than patches or plaques. Since each T lymphoma expressed an abnormal but uniform T-cell phenotype other than mature cytotoxic/suppressor or helper, the neoplastic population could be distinguished from reactive T cells. Reactive elements averaged one-third of the cellular infiltrates and were mainly T cells and macrophages. Langerhans cells were generally normal in number and distribution. Several histopathologic subtypes were identified with diffuse large cell lymphomas, including immunoblastic lymphomas, comprising 71% of cases (15/21). Prediction of the immunophenotype based on cytologic criteria was correct in 67% of cases (14/21). All errors occurred among the 13 high-grade lymphomas. Survival data were consistent with those of prior studies that have indicated that clinical course is dependent on stage and histologic subtype. Non-Hodgkin's cutaneous lymphomas constitute an immunologically, histologically, and clinically heterogeneous group of neoplasms.
[Psychological support in anxiety management for patients affected by chronic kidney disease and treated by dialysis]. (2023)

<b>Introduction:</b> The quality of life of patients with chronic kidney disease stage V is strongly affected by the recommended therapies. Such a situation alters the state of anxiety, which expresses a perception connected to a specific context and it overlaps with trait anxiety, which evaluates relatively stable aspects of being prone to anxiety. The study aims to analyze the anxiety level of uremic patients and to demonstrate the benefit of psychological support either in person or online in order to mostly reduce the state of anxiety. <b>Materials and methods:</b> 23 patients treated at the Nephrology Unit of the San Bortolo Hospital in Vicenza have undergone at least 8 psychological sessions. The first and the eighth sessions have been held in person, while the others were either in person or online based on the patients' preference. The State-Trait Anxiety Inventory (STAI), which means to evaluate the current state of anxiety and aspects of being prone to anxiety, was submitted during the first and the eighth sessions. <b>Results:</b> Patients, before being submitted to psychological treatment, showed high rates of both State and Trait anxiety levels. After eight sessions the trait anxiety features and even better the state anxiety ones have significantly reduced both thanks to in-person or online treatments. <b>Conclusions:</b> A treatment of minimum eight sessions shows a significant improvement of the nephropathic patient's trait and, even better, state anxiety level and it also fosters the achievement of advanced adjustment levels compared to the new clinical status together with an improvement of the quality of life.
Robust control design for a conventional series resonant converter using μ-synthesis (2002)

Because of their reduced switching losses, DC-to-DC resonant converters have been used extensively in the design of smaller size and lighter weight power supplies. The steady state and dynamic behaviors of both the conventional series and parallel resonant converters have been thoroughly analyzed and small-signal models around given nominal operating points have been obtained. These models have been used in the past to design controllers that attempted to keep the output voltage constant in the presence of input perturbations. However, these controllers did not take into account neither load nor components variations, and this could lead to instability in the face of component or load changes. Moreover, prediction of the frequency range for stability was done a posteriori, either experimentally or by a trial and error approach. In this paper we use /spl mu/-synthesis to design a robust controller for a series resonant converter. In addition to robust stability the design objectives include rejection of disturbances at the converter input while keeping the control input and the settling time within values compatible with a practical implementation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α2C Adrenergic Receptor (2019)

Adrenergic G-protein-coupled receptors (GPCRs) mediate different cellular signaling pathways in the presence of endogenous catecholamines and play important roles in both physiological and pathological conditions. Extensive studies have been carried out to investigate the structure and function of β adrenergic receptors (βARs). However, the structure of α adrenergic receptors (αARs) remains to be determined. Here, we report the structure of the human α<sub>2C</sub> adrenergic receptor (α<sub>2C</sub>AR) with the non-selective antagonist, RS79948, at 2.8 Å. Our structure, mutations, modeling, and functional experiments indicate that a α<sub>2C</sub>AR-specific D206<sup>ECL2</sup>-R409<sup>ECL3</sup>-Y405<sup>6.58</sup> network plays a role in determining α<sub>2</sub> adrenergic subtype selectivity. Furthermore, our results show that a specific loosened helix at the top of TM4 in α<sub>2C</sub>AR is involved in receptor activation. Together, our structure of human α<sub>2C</sub>AR-RS79948 provides key insight into the mechanism underlying the α<sub>2</sub> adrenergic receptor activation and subtype selectivity.
Chlamydia trachomatis Infection Does Not Enhance Local Cellular Immunity against Concurrent Candida Vaginal Infection (2001)

Although Th1-type cell-mediated immunity (CMI) is the predominant host defense mechanism against mucosal Candida albicans infection, CMI against a vaginal C. albicans infection in mice is limited at the vaginal mucosa despite a strong Candida-specific Th1-type response in the draining lymph nodes. In contrast, Th1-type CMI is highly effective against an experimental Chlamydia trachomatis genital tract infection. This study demonstrated through two independent designs that a concurrent Candida and Chlamydia infection could not accelerate or modulate the anti-Candida CMI response. Together, these results suggest that host responses to these genital tract infections are independent and not influenced by the presence of the other.
Effect of Breast Silicone Implant Topography on Bacterial Attachment and Growth: AnIn VitroStudy (2022)

Nanotextured breast implants may limit bacterial growth and thus prevent capsular contracture.
Asymmetric Strecker Synthesis of α-Amino Acids via a Crystallization-Induced Asymmetric Transformation Using (R)-Phenylglycine Amide as Chiral Auxiliary (2001)

[reaction: see text]. Diastereoselective Strecker reactions based on (R)-phenylglycine amide as chiral auxiliary are reported. The Strecker reaction is accompanied by an in situ crystallization-induced asymmetric transformation, whereby one diastereomer selectively precipitates and can be isolated in 76-93% yield and dr > 99/1. The diastereomerically pure alpha-amino nitrile obtained from pivaldehyde (R1 = t-Bu, R2 = H) was converted in three steps to (S)-tert-leucine in 73% yield and >98% ee.
Binding of Topotecan to a Nicked DNA Oligomer in Solution (2008)

Topotecan (TPT) is in clinical use as an antitumor agent. It acts by binding to the covalent complex formed between nicked DNA and topoisomerase I, and inserts itself into the single-strand nick, thereby inhibiting the religation of the nick and acting as a poison. A crystal structure analysis of the ternary complex has shown how the drug binds (B. L. Staker, K. Hjerrild, M. D. Feese, C. A. Behnke, A. B. Burgin, L. Stewart, Proc. Natl. Acad. Sci. U.S.A., 2002, 99, 15 387-15 392), but has left a number of unanswered questions. Herein, we use NMR spectroscopy and molecular modeling to show that the solution structure of a complex of TPT with nicked natural DNA is similar, but not identical to the crystal conformation, and that other geometries are of very low population. We also show that the lactone form of TPT binds approximately 40 times more strongly than the ring-opened carboxylate.
Baltasar Dias, «cego da ilha da Madeira»: (2021)

Nascido na ilha da Madeira por volta de 1515, Baltasar Dias é um autor que a história da literatura e da cultura portuguesa não ignora e até exalta como um dos maiores representantes do teatro português popular e de cordel do século XVI. Mas são quase inexistentes os estudos sobre este poeta e dramaturgo, que não aceitou ser desapossado do que era seu por livreiros sem escrúpulos e obteve de D. João III uma licença para imprimir os seus próprios folhetos. Proponho-me revisitar o que se conhece da vida deste autor e esclarecer alguns aspetos da sua produção teatral. A partir das peças de devoção Auto do Nascimento, Auto de Santo Aleixo e Auto de Santa Catarina, apresento neste artigo alguns subsídios para o estudo quer da estética dramática de Baltasar Dias, quer do lugar que este “homem pobre” ocupa na história literária e cultural.
Dynamic Effects on Containment of Air-Curtain Fume Hood Operated with Heat Source (2012)

This study focused on the leakage characteristics of the air-curtain fume hood that are subject to the influences of sash movement and walk-by motion while a high temperature heat source was operated in the hood. The flow visualization and trace gas test method were used to investigate the performance of the air-curtain fume hood. An electric heater was placed in the hood to simulate the heat source. The temperature of the heat source installed inside the air-curtain fume hood varied between 180°C and 300°C. Trace gas tests following the dynamic test methods of EN-14175 protocol were employed to measure the spillages of sulfur hexafluoride gas that were released in the hood. When subject to the influence of sash movement at a heat source temperature lower than 260°C, the leakage level was high at the suction velocity V(s) < 8 m/sec but was negligibly small at V(s) > 10 m/sec. When subject to the influence of people walk-by, the leakage level was relatively low at the suction velocity larger than 8 m/sec at sash height H = 50 cm. The height of the sash opening was a crucial parameter for the containment of the air-curtain fume hood. At the sash opening lower than about 25 cm, suction velocity less than or equal to 6 m/sec was enough to make the sulfur hexafluoride leakage less than the threshold value, 0.65 ppm, suggested by the BG Chemie. The air-curtain fume hood presented a great performance to resist the effect of drafts even though there was a high temperature heat source working in the hood.