gebhart/patrepeval huggingface dataset:
Engineering protease-resistant peptides to inhibit human parainfluenza viral respiratory infection (2021)

ABSTRACT The lower respiratory tract infections affecting children worldwide are in large part caused by the parainfluenza viruses (HPIVs), particularly HPIV3, along with human metapneumovirus and respiratory syncytial virus, enveloped negative-strand RNA viruses. There are no vaccines for these important human pathogens, and existing treatments have limited or no efficacy. Infection by HPIV is initiated by viral glycoprotein-mediated fusion between viral and host cell membranes. A viral fusion protein (F), once activated in proximity to a target cell, undergoes a series of conformational changes that first extend the trimer subunits to allow insertion of the hydrophobic domains into the target cell membrane, and then refold the trimer into a stable postfusion state, driving the merger of the viral and host cell membranes. Lipopeptides derived from the C-terminal heptad repeat (HRC) domain of HPIV3 F inhibit infection by interfering with the structural transitions of the trimeric F assembly. Clinical application of this strategy, however, requires improving the in vivo stability of antiviral peptides. We show that the HRC peptide backbone can be modified via partial replacement of α-amino acid residues with β-amino acid residues to generate α/β-peptides that retain antiviral activity but are poor protease substrates. Relative to a conventional α-lipopeptide, our best α/β-lipopeptide exhibits improved persistence in vivo and improved anti-HPIV3 antiviral activity in animals.
The Transradial Approach for Lower Extremity Vascular Intervention. (2018)

Simultaneous technological advancements in both imaging as well as devices have resulted in an expansion of endovascular options for vascular access. In particular, radial access has traditionally been more favored for coronary interventions; its use in the aortoiliac and lower extremity vasculature has been constrained by the length of devices and the size of sheaths required. However, with increasing catheter shaft lengths, in addition to new thin-walled sheaths allowing for downsizing, the ability to perform transradial interventions on infrainguinal and infrageniculate vessels has been more readily facilitated. In this review, we analyze the potential for transradial therapies in the treatment of peripheral arterial disease (PAD).
Síntese e avaliação farmacológica de protótipos candidatos a fármacos para o tratamento dos sintomas da anemia falciforme (2014)

Americanae nace como un proyecto conjunto que surge dentro de la Red Europea de Información y Documentación sobre América Latina (REDIAL), y que ha afrontado la Biblioteca de la Agencia Española de Cooperación Internacional para el Desarrollo (AECID). Esta nueva biblioteca virtual hace más accesibles los libros digitales de tema americanista a los investigadores y usuarios interesados de cualquier parte del mundo.
Impact of Prostate Health Index Results for Prediction of Biopsy Grade Reclassification During Active Surveillance (2022)

Among active surveillance patients, using Prostate Health Index with clinical data modestly improved prediction of grade reclassification on confirmatory biopsy and did not improve prediction on subsequent biopsies.
Topological Hall Signatures of Two Chiral Spin Textures Hosted in a Single Tetragonal Inverse Heusler Thin Film (2020)

Magnetic skyrmions and antiskyrmions are observed in material classes with different crystal symmetries, where the Dzyaloshinskii-Moriya interaction stabilizes either skyrmions or antiskyrmions. Here, we report the observation of two distinct peaks in the topological Hall effect in a thin film of Mn<sub>2</sub>RhSn. Utilizing a phenomenological approach and electronic transport simulations, these topological Hall effect features are attributed to be direct signatures of two topologically distinct chiral spin objects, namely, skyrmions and antiskyrmions. Topological Hall effect studies allow us to determine the existence of these two topological objects over a wide range of temperature and magnetic fields. In particular, we find skyrmions to be stable at low temperatures, suggesting the increased importance of dipolar interactions.
Simple and Accurate Fluorescence Lifetime Measurement Scheme Using Traditional Time-Domain Spectroscopy and Modern Digital Signal Processing (2016)

Fluorescence lifetime measurement is an essential process for evaluation and application of optical gain media. An accurate and convenient scheme for fluorescence lifetime measurement of complex emission processes with either single or multiple fluorescence lifetimes is essential. We developed a new convolution-based scheme for fluorescence lifetime measurement. The innovation of the scheme lies in a combination of convolution-based digital signal processing algorithms with a low cost and simple time-domain spectroscopic setup. The convolution-based scheme is able to achieve accurate microsecond fluorescence lifetime resolution using the spectroscopic setup with only millisecond fluorescence lifetime resolution, for both single or multiple fluorescence lifetimes. We demonstrated the performance of the scheme, both theoretically and experimentally, by measuring fluorescence lifetimes associated with complicated emission processes in bismuth-erbium-doped fibers and erbium-doped fiber.
Fano-Like Resonances Arising from Long-Lived Molecule-Plasmon Interactions in Colloidal Nanoantennas (2012)

We examine ultrafast dynamics in a coupled molecule-plasmon system. Using a new ultrafast Raman technique called surface enhanced-femtosecond stimulated Raman spectroscopy (SE-FSRS), we prove that plasmonic nanoparticles and adsorbed molecules are coupled by the appearance of Fano-like lineshapes, which arise from the interaction of narrowband vibrational coherences and the broadband plasmon resonance. We probe the effect of plasmon energy on the vibrational lineshapes and observe changes in the phase of the line shape dispersion. Finally, we examine the effect of plasmon-molecule coupling on the molecular vibrational coherence lifetime. Surprisingly, coupling of the molecular vibration to the plasmon does not significantly shorten the vibrational coherence dephasing time. Better understanding of the ultrafast dynamics of excited vibrational states and vibrational coherences in coupled molecular-plasmonic systems should assist in developing a mechanism-based view of plasmonically enhanced photovoltaic and photocatalytic systems.
Screening decreases prostate cancer death: First analysis of the 1988 Quebec Prospective Randomized Controlled Trial (1999)

If PSA screening is started at the age of 50 years (or 45 years in the higher risk population), annual or biannual PSA alone is highly efficient to identify the men who are at high risk of having prostate cancer. Coupled with treatment of localized disease, this approach demonstrates, for the first time, that early diagnosis and treatment permits a dramatic decrease in deaths from prostate cancer.
Crystal and molecular structure of three isomers of dichlorodiamminedihydroxoplatinum(IV): cis-trans isomerization on recrystallization from water (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal and molecular structure of three isomers of dichlorodiamminedihydroxoplatinum(IV): cis-trans isomerization on recrystallization from waterReiko Kuroda, Stephen Neidle, Ismail M. Ismail, and Peter J. SadlerCite this: Inorg. Chem. 1983, 22, 24, 3620–3624Publication Date (Print):November 1, 1983Publication History Published online1 May 2002Published inissue 1 November 1983https://pubs.acs.org/doi/10.1021/ic00166a026https://doi.org/10.1021/ic00166a026research-articleACS PublicationsRequest reuse permissionsArticle Views403Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A new single inductor bipolar multiple output (SIBMO) boost converter using pulse frequency modulation (PFM) control for OLED drivers and optical transducers (2015)

This study proposes a single-inductor bipolar multiple-output (SIBMO) boost converter utilizing pulse frequency (PFM) control for organic light-emitting diode (OLED) drivers and optical transducers. The purpose of the converter designed herein is to provide multiple voltage sources with opposite polarities to meet the requirements of various applications such as OLEDs or optical transducers. The bipolar voltage sources are essential for offering alternating driving voltages to extend the lifetime of OLEDs. The converter boosts the input of 2.8 V to two positive and two negative outputs, i.e., +12 V, +6 V, −12 V, and −6 V. Different from the commonly-used pulse width modulation (PWM), the constant on-time (COT) approach is adopted herein with a dynamic charging algorithm to automatically adjust the operating frequency, thus profiting from less circuit complexity, improvement of cross regulation, and high transfer efficiency in unbalanced load cases. The total maximum output power is 320 mW, as the switching frequency varies from 650 kHz to 0 Hz, and the maximum efficiency reaches 83.1% by simulation. The converter was fabricated by TSMC 0.25μm 1P3M high voltage CMOS technology for verification.
Intersection of population variation and autoimmunity genetics in human T cell activation (2014)

T lymphocyte activation by antigen conditions adaptive immune responses and immunopathologies, but we know little about its variation in humans and its genetic or environmental roots. We analyzed gene expression in CD4(+) T cells during unbiased activation or in T helper 17 (T(H)17) conditions from 348 healthy participants representing European, Asian, and African ancestries. We observed interindividual variability, most marked for cytokine transcripts, with clear biases on the basis of ancestry, and following patterns more complex than simple T(H)1/2/17 partitions. We identified 39 genetic loci specifically associated in cis with activated gene expression. We further fine-mapped and validated a single-base variant that modulates YY1 binding and the activity of an enhancer element controlling the autoimmune-associated IL2RA gene, affecting its activity in activated but not regulatory T cells. Thus, interindividual variability affects the fundamental immunologic process of T helper activation, with important connections to autoimmune disease.
Submicrosecond correlations in photoluminescence from InAs quantum dots (2004)

Photon correlation measurements reveal memory effects in the optical emission of single InAs quantum dots with time scales from 10 to 800 ns. With above-band optical excitation, a long-time scale negative correlation (antibunching) is observed, while with quasiresonant excitation, a positive correlation (blinking) is observed. A simple model based on long-lived charged states is presented that approximately explains the observed behavior, providing insight into the excitation process. Such memory effects can limit the internal efficiency of light emitters based on single quantum dots, and could also be problematic for proposed quantum-computation schemes.
Si 3 N 4 -based photonic crystal membranes (2004)

We describe the fabrication process of silicon nitride (Si<sub>3</sub>N<sub>4</sub>) based two-dimensional photonic crystals. The fabrication process mainly involves e-beam direct-write lithography and reactive ion etching. The concerned photonic crystal structures consist of a periodic arrangement of sub-micrometric holes transferred into a suspended Si<sub>3</sub>N<sub>4</sub> membrane using a poly-methylmethacrylate resist layer as a mask. Numerical simulations based on a plane wave expansion method for 2D photonic band gap approximation were conducted to determine the design parameters of the photonic crystal membranes. Flat and stress free photonic crystal membranes were achieved with very good control in sidewall profile and feature shape.
Neuromodulatory Therapy to Improve Erectile Function Recovery Outcomes After Pelvic Surgery (2006)

Erectile dysfunction is a well recognized and yet ineffectively averted complication of pelvic surgery. Neuromodulatory therapy offers a therapeutic approach for addressing the neuropathic changes of the penis that occurs in this context with the goal of maximally preserving erectile function postoperatively. While several specific neuromodulatory applications have gained interest for their potential benefit with pelvic surgery, determining their actual roles awaits the completion of controlled clinical trials.
A Leakage Management System Based on Clock Gating Infrastructure for a 65-nm Digital Base-Band Modem Chip (2006)

In this paper we present a leakage management system which takes advantage of the existing clock gating infrastructure. This methodology avoids both RTL and software changes, at the block and chip level. We illustrate this approach with a 65-nm digital base band modem while achieving standby leakage in the 100-muA range and overall 1200times leakage reduction including process, circuit and system optimization
Hepatocellular carcinoma and chemoembolization (2001)

Chemoembolization has a role in the palliative treatment of hepatocellular carcinoma. Our response rates and toxicity data are consistent with those in the published literature. However, new treatments are needed and prevention of disease by reduction in the prevalence of chronic hepatitis B and C will be required to significantly reduce mortality from this tumour.
A Review of Power Decoupling Techniques for Microinverters With Three Different Decoupling Capacitor Locations in PV Systems (2012)

The reliability of the microinverter is a very important feature that will determine the reliability of the ac-module photovoltaic (PV) system. Recently, many topologies and techniques have been proposed to improve its reliability. This paper presents a thorough study for different power decoupling techniques in single-phase microinverters for grid-tie PV applications. These power decoupling techniques are categorized into three groups in terms of the decoupling capacitor locations: 1) PV-side decoupling; 2) dc-link decoupling; and 3) ac-side decoupling. Various techniques and topologies are presented, compared, and scrutinized in scope of the size of decoupling capacitor, efficiency, and control complexity. Also, a systematic performance comparison is presented for potential power decoupling topologies and techniques.
Novel hybrid 12-pulse line interphase transformer boost-type rectifier with controlled output voltage (2004)

This paper describes two novel hybrid 12-pulse line interphase transformer rectifier systems with integrated single-switch or two-switch boost-type output stage. The boost stage allows controlling the output voltage to a constant value independent of line voltage or output power variations. In combination with low complexity and/or high reliability the hybrid rectifier concept therefore is of potential interest for supplying electrically powered actuators of future more-electric-aircrafts. The principle of operation and the dimensioning of the systems are discussed. Furthermore, a control concept guaranteeing a symmetric distribution of the load current to the individual systems of the two-switch topology is proposed. The theoretical considerations are experimentally confirmed for a 10 kW laboratory prototype. Finally, the single- and the two-switch system are comparatively evaluated concerning input current ripple, power factor, and overall efficiency.
Feasibility of Contactless Pulse Rate Monitoring of Neonates using Google Glass (2015)

In neonatal intensive care units in hospitals, vital signs of neonates are monitored continuously using wired sensors. However, these wired sensors introduce skin irritations, pain, discomfort and sleep disruptions for the neonates. State of the art camera-based vital sign algorithms are becoming po
ChemInform Abstract: Crystal Structure of Tin(II) Perchlorate Trihydrate. (2015)

Abstract [Sn(H 2 O) 3 ](ClO 4 ) 2 is prepared by the redox reaction of Cu(ClO 4 ) 2 and Sn in HClO 4 followed by crystallization in a freezer (253 K).
Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis (1999)

The importance of B7 costimulation in regulating T cell expansion and peripheral tolerance suggests that it may also play a significant regulatory role in the development of autoimmune disease. It is unclear whether B7 costimulation is involved only in the expansion of autoreactive T cells in the periphery, or if it is also required for effector activation of autoreactive T cells in the target organ for mediating tissue injury and propagating autoimmune disease. In this study, the role of B7-CD28 costimulation and the relative importance of B7 costimulators for the induction and effector phases of experimental autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte glycoprotein (MOG) peptide were examined. Wild-type, B7-1/B7-2-deficient mice, or CD28-deficient C57BL/6 mice were immunized with MOG 35-55 peptide. Mice lacking both B7-1 and B7-2 or CD28 showed no or minimal clinical signs of EAE and markedly reduced inflammatory infiltrates in the brain and spinal cord. However, mice lacking either B7-1 or B7-2 alone developed clinical and pathologic EAE that was comparable to EAE in wild-type mice, indicating overlapping functions for B7-1 and B7-2. Resistance to EAE was not due to a lack of induction of T helper type 1 (Th1) cytokines, since T cells from B7-1/B7-2(-/-) mice show reduced proliferative responses, but greater interferon gamma production compared with T cells from wild-type mice. To study the role of B7 molecules in the effector phase of the disease, MOG 35-55-specific T lines were adoptively transferred into the B7-1/B7-2(-/-) and wild-type mice. Clinical and histologic EAE were markedly reduced in B7-1/B7-2(-/-) compared with wild-type recipient mice. These results demonstrate that B7 costimulation has critical roles not only in the initial activation and expansion of MOG-reactive T cells, but also in the effector phase of encephalitogenic T cell activation within the central nervous system.
Noninvasive Measurement of Cardiac Output in Hemodialysis Patients by Task Force Monitor: A Comparison with the Transonic System (2007)

Cardiovascular disease is the leading cause of morbidity and mortality in maintenance hemodialysis (MHD) patients. The Transonic (TRS; Transonic Systems, Ithaca, NY) device is frequently used for determination of cardiac output (CO) by an indicator dilution technique. The Task Force Monitor (TFM; CN Systems, Graz, Austria) has gained attention as noninvasive tool for continuous beat-to-beat assessment of cardiovascular variables, including CO by impedance cardiography. Despite its use in cardiology and intensive care settings, the TFM has yet not been validated in dialysis patients. This study compares CO measurements in 12 MHD patients by TFM and TRS. Bland-Altman and regression analysis were used. CO was measured simultaneously by TRS and TFM. Average CO was 5.4 L/min by TRS and 5.0 L/min by TFM, respectively. Bland-Altman analysis revealed no significant systematic differences between the two methods (mean difference: 0.4 L/min; SD: 0.6; p > 0.05). Linear regression analysis showed significant correlation between both techniques (r = 0.802, p = 0.002). The SD of mean individual CO values was 1.1 L/min with TRS and 0.8 L/min with TFM, respectively.CO measured by TFM and TRS does not differ significantly, thus making the TFM an attractive noninvasive tool for the continuous beat-to-beat assessment of CO in MHD patients.
The Battle of the Water Sensor Networks (BWSN): A Design Challenge for Engineers and Algorithms (2008)

Following the events of September 11, 2001, in the United States, world public awareness for possible terrorist attacks on water supply systems has increased dramatically. Among the different threats for a water distribution system, the most difficult to address is a deliberate chemical or biological contaminant injection, due to both the uncertainty of the type of injected contaminant and its consequences, and the uncertainty of the time and location of the injection. An online contaminant monitoring system is considered as a major opportunity to protect against the impacts of a deliberate contaminant intrusion. However, although optimization models and solution algorithms have been developed for locating sensors, little is known about how these design algorithms compare to the efforts of human designers, and thus, the advantages they propose for practical design of sensor networks. To explore these issues, the Battle of the Water Sensor Networks (BWSN) was undertaken as part of the 8th Annual Water Distribution Systems Analysis Symposium, Cincinnati, Ohio, August 27–29, 2006. This paper summarizes the outcome of the BWSN effort and suggests future directions for water sensor networks research and implementation.
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis (2021)

Visceral leishmaniasis (VL) is a parasitic disease endemic across multiple regions of the world and is fatal if untreated. Current therapies are unsuitable, and there is an urgent need for safe, short-course, and low-cost oral treatments to combat this neglected disease. The benzoxaborole chemotype has previously delivered clinical candidates for the treatment of other parasitic diseases. Here, we describe the development and optimization of this series, leading to the identification of compounds with potent <i>in vitro</i> and <i>in vivo</i> antileishmanial activity. The lead compound (DNDI-6148) combines impressive <i>in vivo</i> efficacy (>98% reduction in parasite burden) with pharmaceutical properties suitable for onward development and an acceptable safety profile. Detailed mode of action studies confirm that DNDI-6148 acts principally through the inhibition of <i>Leishmania</i> cleavage and polyadenylation specificity factor (CPSF3) endonuclease. As a result of these studies and its promising profile, DNDI-6148 has been declared a preclinical candidate for the treatment of VL.
A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei (1992)

Clone B is a cytotoxic T cell clone induced by immunization with Plasmodium yoelii sporozoites which recognizes an epitope on both the P. yoelii and Plasmodium berghei circumsporozoite proteins. It is CD8, uses the V beta 8.1 TCR, and is Kd restricted. When adoptively transferred, it protects mice against infection by both species of malaria sporozoites, and this protection is dependent on IFN-gamma. Clone B cells are more broadly reactive and protective than previously described murine T cell clones against malaria. Clone B may be an important model for immune protection against the spectrum of variant parasites in nature.