gebhart/patrepeval huggingface dataset:
Development of the Sm14/GLA-SE - schistosomiasis vaccine candidate: An open, not placebo-controlled, standardized dose immunization phase Ib clinical trial targeting healthy young women (2022)

Abstract We report the successful closure of Phase I clinical trials of the Schistosoma mansoni 14 kDa fatty acid-binding protein (Sm14) + glucopyranosyl lipid A in squalene emulsion (GLA-SE) vaccine candidate against human Schistosomiasis, comprising Phases Ia and Ib. Shown here are the results of Phase Ib, an open, not placebo-controlled, standardized-dose immunization trial, involving 10 healthy 18-49 years old women submitted to the same clinical protocol and the same batch of cGMP Sm14+GLA-SE used in Phase Ia, which was one on men. Fifty µg Sm14 protein plus 10 µg GLA-SE per dose were given intramuscularly thrice at 30-day intervals. Participants were assessed clinically, biochemically, and immunologically for up to 120 days. In preambular experiments involving vaccinated pregnant female rabbits, we did not find any toxicological feature either in offspring or mothers, as ascertained by histopathology and biochemical parameters. The vaccine induced adaptive immunity in the animals, as defined by the detection of anti-Sm14 antibodies in the sera. In women, neither serious nor light adverse events were observed. Sm14+GLA-SE vaccination induced high titers of anti-Sm14 serum IgG antibody production. Total anti-IgG serum levels remained high 120 days after the first vaccination dose. Significant increases in Sm14-specific total IgG, IgG1, and IgG3 were observed 30 days after the first vaccination, with specific IgG2 and IgG4 after 60 days. Sm14+GLA-SE vaccination also elicited robust cytokine responses with increased TNFα, IFNγ, and IL-2 profiles in all female vaccinees on days 90 and 120. As in Phase Ia, the Sm14+GLA-SE vaccine was shown to be strongly immunogenic and well tolerated. The completion of Phase I clinical trials performed to the highest standards set by the Good Clinical Research Practice (GCP) standards and pre-clinical data in pregnant rabbits enabled the vaccine candidate to proceed to Phase II clinical trials in endemic areas. Study registration ID NCT01154049 at http://www.clinicaltrials.gov . Brazilian Registry of Clinical Trials UTN: U1111-1135-6815
Regional CBF in chronic stable TBI treated with hyperbaric oxygen. (2004)

To investigate whether Hyperbaric Oxygen Therapy (HBO2) could improve neurologic deficits and regional cerebral blood flow (rCBF) in chronic traumatic brain injuries (TBI), the authors employed a nonrandomized control pilot trial. Five subjects, at least three years post head injury, received HBO2. Five head injured controls (HIC) were matched for age, sex, and type of injury. Five healthy subjects served as normal controls. Sixty-eight normal volunteers comprised a reference data bank against which to compare SPECT brain scans. HBO2 subjects received 120 HBO2 in blocks of 80 and 40 treatments with an interval five-month break. Normal controls underwent a single SPECT brain scan, HBO2, and repeat SPECT battery. TBI subjects were evaluated by neurologic, neuropsychometric, exercise testing, and pre and post study MRIs, or CT scans if MRI was contraindicated. Statistical Parametric Mapping was applied to SPECT scans for rCBF analysis. There were no significant objective changes in neurologic, neuropsychometric, exercise testing, MRIs, or rCBF. In this small pilot study, HBO2 did not effect clinical or regional cerebral blood flow improvement in TBI subjects.
Analysis of Variance for Replicated Spatial Point Patterns in Clinical Neuroanatomy (1991)

Abstract Our application concerns the analysis of the spatial distributions of pyramidal neurons in the cingulate cortex of human subjects in three diagnostic groupings. Our purpose is to develop and apply several methods for the analysis of replicated spatial point patterns to identify anatomical differences between normal, schizoaffective, and schizophrenic persons at the time of death. We begin with a scaled Poisson analysis that uncovers significant differences between the groups in the mean numbers of neurons in the sampled region, as well as a high degree of extra-Poisson variation in the distribution of cell counts within these groups. We then proceed to calculate two different functional descriptors of pattern for each subject to investigate departures from competely random patterns, both between subjects and between groups, while adjusting for cell count differences. The distributions of our main functional pattern descriptor and of our derived test statistic are unknown. For nonparametric inference, we propose a bootstrap procedure in which we resample our data to estimate the null distribution of our test statistic, even though the null hypothesis is not supported by these data. A simulation study provides evidence of the validity and power of our procedure for bootstrap hypothesis testing in our context. We conclude with a summary of what has been learned through this study about the cellular structure of cingulate cortex in persons with psychotic disorders and with some suggested directions for future research.
Spatially Resolved Raman Spectroscopy Study of Transformed Zones in Magnesia‐Partially‐Stabilized Zirconia (1989)

Raman vibrational spectroscopy provides an effective phase characterization technique in materials systems containing particle dispersions of the tetragonal and monoclinic polymorphs of zirconia, each of which yields a unique Raman spectrum. An investigation is reported to assess a novel, spatially resolved Raman spectroscopy system in the study of transformed zones surrounding cracks in partially stabilized MgO–ZrO 2 (PSZ). The experimental arrangement uses an imaging (two‐dimensional) photomultiplier tube to produce a one‐dimensional Raman profile of phase compositions along a slitlike laser beam without translation of either the sample or the laser beam and without scanning the spectrometer. For the present optical configuration, the spatial resolution is estimated to be equivalent to the detector resolution of 28 pm and does not appear to be reduced because of secondary scattering events in the PSZ. Results from phase characterization studies of the size, frontal morphology, and extent of transformation of transformation zones surrounding cracks produced under monotonic and cyclic loading conditions are presented. Particularly large zones are observed in the peak‐toughened material, extending 1300 μm ahead of the crack tip with widths of up to 3000 μm. Good agreement is found with similar results determined using optical interference microscopy.
Enzyme-free release of adhered cells from standard culture dishes using intermittent ultrasonic traveling waves (2019)

Cell detachment is essential in culturing adherent cells. Trypsinization is the most popular detachment technique, even though it reduces viability due to the damage to the membrane and extracellular matrix. Avoiding such damage would improve cell culture efficiency. Here we propose an enzyme-free cell detachment method that employs the acoustic pressure, sloshing in serum-free medium from intermittent traveling wave. This method detaches 96.2% of the cells, and increases its transfer yield to 130% of conventional methods for 48 h, compared to the number of cells detached by trypsinization. We show the elimination of trypsinization reduces cell damage, improving the survival of the detached cells. Acoustic pressure applied to the cells and media sloshing from the intermittent traveling wave were identified as the most important factors leading to cell detachment. This proposed method will improve biopharmaceutical production by expediting the amplification of tissue-cultured cells through a more efficient transfer process.
Application of the British Gas/Lurgi slagging gasifier (1985)

British Gas Lurgi slagging gasification and its status of commercial availability are presented. Two important cases for the application of slagging gasification are discussed in some detail: integrated gasification combined cycle (IGCC) power generation, and production of hydrogen from petroleum coke. Cost figures are presented for power generation and hydrogen production. Special attention is given to both present and the more stringent environmental regulations expected in the future.
Probabilistic diagnosability of hybrid systems (2015)

The model-based fault diagnosability analysis is concerned with the timely detection and isolation of faults by using the system model and observations of the system output. In this paper, we propose the (δd, δm, α)-diagnosability notion for hybrid systems with probabilistic reset, where the faults are diagnosed by observing the timed event sequences. We also present an approach for the analysis of such diagnosability.
Emitter Phased-Array Based on Nonlinear Metamaterial Nanocavities. (2014)

Abstract not provided.
New technology assessment and current and upcoming therapies for underactive bladder (2018)

The UAB regulatory working group recognizes the path forward should include engaging the FDA and other regulatory organizations that may harmonize and formalize guidance for regulatory trial designs for therapeutics for UAB.
Supplementary Figure 3 from High Efficacy of a <i>Listeria</i>-Based Vaccine against Metastatic Breast Cancer Reveals a Dual Mode of Action (2023)

Supplementary Figure 3 from High Efficacy of a &lt;i&gt;Listeria&lt;/i&gt;-Based Vaccine against Metastatic Breast Cancer Reveals a Dual Mode of Action
Glucose‐dependent regulation of the l ‐pyruvate kinase gene in a hepatoma cell line is independent of insulin and cyclic AMP (1994)

Hepatocyte‐like mhAT3F cells have been derived from the hepatoma of a transgenic mouse expressing the SV40 large T antigen under the control of the antithrombin III gene regulatory region (Antoine, B., Levrat, F., Vallet, V., Berbar, T., Cartier, N., Dubois, N., Briand, P., and Kahn, A. (1992) Gene expression in hepatocyte‐like lines established by targeted carcinogenesis in transgenic mice. Exp. Cell. Res. 200, 175–185; F. Levrat et al., unpublished results). In these cells, the l ‐PK gene is transcriptionally activated by glucose, as it is in vivo and in cultured hepatocytes. However, in contrast to the l ‐PK gene regulation in the liver and isolated hepatocytes, the glucose responsiveness does not require insulin and is not blocked by cyclic AMP. In mhAT3F cells, the insensitivity to insulin might be due to the replacement of insulin‐dependent glucokinase by insulin‐independent hexokinases able to phosphorylate glucose in the absence of the hormone. The glucose‐dependent activation of the l ‐PK gene is delayed, requires ongoing protein synthesis, and is mediated by the same glucose response element as in vivo and in isolated hepatocytes. These results suggest that the glucose‐dependent signaling pathway responsible for the transcriptional activation of glycolytic and lipogenic genes requires glucose phosphorylation, a phenomenon that is insulin‐dependent in the liver but insulin‐independent in cultured hepatoma cells. Nevertheless, the action of glucose 6‐phosphate is most likely indirect.— Lefrançois‐Martinez, A.‐M., Diaz‐Guerra, M.‐J. M., Vallet, V., Kahn, A., Antoine, B. Glucose‐dependent regulation of the L‐pyruvate kinase gene in a hepatoma cell line is independent of insulin and cyclic AMP. FASEB J. 8: 89‐96; 1994.
Developmental Changes in Neonatal and Infant Skin Structures During the First 6 Months: In Vivo Observation (2016)

Our results reveal that infant skin is in a developmental stage structurally up to 3 months of age, paralleling skin functional and developmental maturation.
Current conduction mechanism of Si/Ti-based Ohmic contacts to n-GaN (2000)

We have investigated the Ohmic contact formation mechanism of Si/Ti-based contacts to n-GaN. The Si/Ti contact system was selected because Ti silicides have a low work function and also Si has been used widely as an n-type dopant. Our experimental results show that the Ohmic behavior of Si/Ti-based contacts were attributed to the low barrier height of the Ti silicide/GaN interface. The contact resistance of Si/Ti-based Ohmic contacts decreased exponentially with the measuring temperature. It can be concluded that current flows over the low barrier height by thermionic emission.
Topical doxycycline monohydrate hydrogel 1% targeting proteases/PAR2 pathway is a novel therapeutic for atopic dermatitis (2020)

Atopic Dermatitis (AD) is characterized by skin barrier disruption and an aberrant immune response. Doxycycline is tetracycline antibiotics broadly used systemically to treat inflammatory dermatologic conditions. Several studies have shown doxycycline has anti-inflammatory and pro-healing properties, mainly by blocking tissue proteolytic activity. It is our hypothesis that daily application of a novel doxycycline topical formulation in AD subjects will reduce severity of the disease, by blocking cutaneous proteases activity and restoring skin barrier function and inflammation. To test this hypothesis, we performed a proof of concept, open-label clinical study. Subjects enrolled in the study (n = 15) applied NanoDOX<sup>®</sup> Hydrogel 1% daily for 4 weeks on a chosen eczematous area. Investigational drug was well tolerated, and no local or systemic adverse events due to investigational drug were reported. Notably, a significant clinical improvement was observed based on a modified Eczema Area & Severity Index (EASI) score of the treated area from start of treatment to 14 and 28 days post-treatment (P < .001). A significant improvement of pruritus was also observed (P = .02). This proof of concept clinical trial is first to explore the impact of a non-systemic doxycycline treatment on AD patients. Our results provide evidence to investigate novel AD treatment strategies targeting cutaneous proteases activity.
Terahertz communication: The opportunities of wireless technology beyond 5G (2018)

Over the past years, carrier frequencies used for wireless communications have been increasing to meet bandwidth requirements. The engineering community witnessed the development of wide radio bands such as the millimeter-wave (mmW) frequencies to fulfill the explosive growth of mobile data demand and pave the way towards 5G networks. Other research interests have been steered towards optical wireless communication to allow higher data rates, improve physical security and avoid electromagnetic interference. Nevertheless, a paradigm change in the electromagnetic wireless world has been witnessed with the exploitation of the Terahertz (THz) frequency band (0.1–10 THz). With the dawn of THz technology, which fills the gap between radio and optical frequency ranges, ultimate promise is expected for the next generation of wireless networks. In this paper, the light is shed on a number of opportunities associated with the deployment of the THz wireless links. These opportunities offer a plethora of applications to meet the future communication requirements and satisfy the ever increasing user demand of higher data rates.
An identification method for static and dynamic friction coefficients (2007)

This paper deals with the identification of static and dynamic friction coefficients. An approach based on limit cycles properties once a regulated mechanical system is brought to oscillations is proposed. This leads to an explicit formulation in the regulator parameters on one part, and the oscillation amplitude and period on the other part. The method is validated by a simulation example and an experimental benchmark.
Solid Photonic Band-Gap Fiber with 400 nm Bandwidth and Loss below 4 dB/km at 1520 nm (2007)

We demonstrate a wide-band and low-loss (< 4 dB/km at 1520 nm) solid photonic band-gap fiber (PBGF). The fiber is practically single-mode in a long length regime and has a large anomalous dispersion over a wide wavelength range.
Service Infrastructures (2006)

This chapter contains sections titled: Introduction Requirements for Future Service Platform Architectures Generic Service Elements and Enabling Technologies Acknowledgment References
Unit Commitment for Isolated Microgrids Considering Frequency Control (2016)

This paper presents a mathematical model of frequency control in isolated microgrids, which is integrated into the Unit Commitment (UC) problem. In conventional UC formulations, power outputs are considered fixed between two periods, yielding a staircase pattern with respect to the energy balance of the generation and demand for a typical dispatch time horizon (e.g., 24 h). However, in practice generation units that participate in frequency control may see a change in their output within a single dispatch time interval (e.g., 5 min), depending on the changes in the demand and/or renewable generation. The proposed approach considers these changes in the generation output using a linear model, and based on that, a novel UC mixed integer quadratic programming, with linear constraints and quadratic objective function, is developed which yields a more cost efficient solution for isolated microgrids. The proposed UC is formulated based on a day-ahead with model predictive control approach. To test and validate the proposed UC, a modified version of a CIGRE benchmark test system is used. The results demonstrate that the proposed UC would reduce the operational costs of isolated microgrids compared to conventional UC methods, at similar complexity levels and computational costs.
Regiosymmetric Poly(dialkylphenylenedioxythiophene)s: Electron‐Rich, Stackable π‐Conjugated Nanoribbons (2006)

Colored ribbons: The soluble, electron-rich conjugated title polymer (alkyl=dodecyl) with a regiosymmetric structure was synthesized by Grignard metathesis. The polymer displays strong thermochromism in solution. AFM images of spin-coated films show the formation of nanoribbons, and 2D-WAXS analysis reveals 2D order in the bulk material (see picture). The polymer is thus a promising candidate for device applications. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z602894_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Low cost biosorbents from fungi for heavy metals removal from wastewater (2019)

In the current study, new biomasses were prepared from fungi isolates including, Penicillium chrysogenum and Aspergillus ustus and utilized for the removal of heavy metals. During the study, the influences of various experimental factors including solution pH, temperature, and contact time on biosorption process were investigated. The synthesized fungi biosorbents were successfully applied for the removal of heavy metals from various waste effluents. The experimental results were indicated the excellent uptake property of the materials for target heavy metals. The average concentrations of Cd (II), Cu (II), and Pb (II) in different wastewater samples collected from Western, Eastern, and Northern region of Saudi Arabia were found to be in the range of 2.6–234 µg/L. The concentrations of Cu(II) in all the analyzed contaminated water samples were fairly exceeded the maximum concentration level for drinking water stipulated by World Health Organization. The applied biosorption technique for heavy metal removal is new, low cost and was adopted in eco-friendly way.
Endosomal sorting results in a selective separation of the protein corona from nanoparticles (2023)

The formation of the protein corona is a well-known effect when nanoparticles (NP) are exposed to biological environments. The protein corona is the most important factor, which determines the rate and route of endocytosis, and decisively impacts cellular processes and even the release of the active pharmaceutical ingredient from the nanoparticles. While many studies concentrate on the effect of the protein corona formation extracellularly or the uptake consequences, little is known about the fate of the protein corona inside of cells. Here, we reconstruct for the first time the separation of the protein corona from the NPs by the cell and their further fate. Ultimately, the NPs and protein corona are separated from each other and end up in morphologically different cellular compartments. The cell directs the NPs towards recycling endosomes, whereas the protein corona gathers in multivesicular bodies. From this, we conclude that the NPs are prepared for subsequent exocytosis, while the protein corona remains in the cell and is finally metabolized there.
Tin Phosphide as a Promising Anode Material for Na‐Ion Batteries (2014)

Sn4 P3 is introduced for the first time as an anode material for Na-ion batteries. Sn4 P3 delivers a high reversible capacity of 718 mA h g(-1), and shows very stable cycle performance with negligible capa-city fading over 100 cycles, which is attributed to the confinement effect of Sn nanocrystallites in the amorphous phosphorus matrix during cycling.
A scanning tunneling microscope controlled field emission microprobe system (1991)

A novel approach based on scanning tunneling microscopy controlled field emission with microlens to form an exceptionally high brightness electron source and low aberration electron probe forming system has been explored. Electron optical studies of such a microsource have shown it to have a brightness two to three orders of magnitude greater than conventional field emission sources at energies in the low keV range and the ability to form an ultrahigh resolution probe with diameter in the 1 to 10 nm range in conjunction with additional microlenses. Encouraging preliminary experimental results have been obtained.
Malondialdehyde-deoxyguanosine and bulky DNA adducts in schoolchildren resident in the proximity of the Sarroch industrial estate on Sardinia Island, Italy (2013)

Air quality is a primary environmental concern in highly industrialised areas, with potential health effects in children residing nearby. The Sarroch industrial estate in Cagliari province, Sardinia Island, Italy, hosts the world's largest power plant and the second largest European oil refinery and petrochemical park. This industrial estate produces a complex mixture of air pollutants, including benzene, heavy metals and polycyclic aromatic hydrocarbons. Thus, we conducted a cross-sectional study to evaluate the prevalence of malondialdehyde-deoxyguanosine adducts in the nasal epithelium of 75 representative children, aged 6-14 years, attending primary and secondary schools in Sarroch in comparison with 73 rural controls. Additionally, the levels of bulky DNA adducts were analysed in a subset of 62 study children. DNA damage was measured by (32)P-postlabelling methodologies. The air concentrations of benzene and ethyl benzene were measured in the school gardens of Sarroch and a rural village by diffusive samplers. Outdoor measurements were also performed in other Sarroch areas and in the proximity of the industrial estate. The outdoor levels of benzene and ethyl benzene were significantly higher in the school gardens of Sarroch than in the rural village. Higher concentrations were also found in other Sarroch areas and in the vicinity of the industrial park. The mean levels of malondialdehyde-deoxyguanosine adducts per 10(8) normal nucleotides ± standard error (SE) were 74.6±9.1 and 34.1±4.4 in the children from Sarroch and the rural village, respectively. The mean ratio was 2.53, 95% confidence interval (CI): 1.71-2.89, P < 0.001, versus rural controls. Similarly, the levels of bulky DNA adducts per 10(8) normal nucleotides ± SE were 2.9±0.4 and 1.6±0.2 in the schoolchildren from Sarroch and the rural village, respectively. The means ratio was 1.90, 95% CI: 1.25-2.89, P = 0.003 versus rural controls. Our study indicates that children residing near the industrial estate have a significant increment of DNA damage.