gebhart/patrepeval huggingface dataset:
Impact of RF Impairments on a DS-CDMA Receiver (2004)

This letter provides an analysis of the impact of classical radio frequency (RF) front-end impairments (RF mismatch and direct current (dc) offset) on the performance of direct-sequence code-division multiple-access (DS-CDMA) receivers; such issues are of particular importance in the case of zero intermediate-frequency (Zero-IF) receivers. Using a standard expression of the baseband signals as well as basic properties of spreading codes used in DS-CDMA communications, we show that the consequence of such RF mismatch and dc offset is essentially a degradation of the wanted signal's level and an increase of the noise power. We give closed-form expressions (in E/sub b//N/sub 0/ form) for both. The results are then shown to be in accordance with numerical simulations utilizing the codes of the universal terrestrial radio access in the frequency-division duplex mode downlink standard.
Personalization of Semantic Web Services. (2010)

Abstract. Nowadays web users have clearly expressed their wishes to receive and interact with personalized services directly. However, existing approaches, largely syntactic content-based, fail to provide robust, accurate and useful personalized services to its users. Towards such an issue, the semantic web provides enabling technologies to annotate and match services ’ descriptions with a users’ features, interests and preferences, thus allowing for more efficient access to services and then information. The aim of our work, part of service personalization, is on automated instantiation of services which is crucial for advanced usability i.e., how to prepare and present services ready to be executed while limiting useless interactions with users? To this end, we exploit Description Logics reasoning through semantic matching to i) identify useful parts of a user profile that satisfy services requirements (i.e., input parameters) and ii) compute the description required by a service to be executed but not provided by the profile. Finally, the scalability of our approach has been evaluated through its integration in the service consumption of the EC-funded project SOA4All.
Metal complexes based on a bis(2-pyridylmethyl)amine-based scaffold and methods of making the same (2023)

A catalyst includes a bis(2-pyridylmethyl)amine-based ligand. A method of forming a catalyst, may include: reacting bis(2-pyridylmethyl)amine-based compound with a terminal azide and/or a terminal alkyne in the presence of Cu(I) to form a bis(2-pyridylmethyl)amine-based ligand. A method of using such catalysts may include neutralizing toxicity of at least one organophosphorus-based compound by reacting the organophosphorus-based compound with a bis(2-pyridylmethyl)amine-based ligand-metal complex.
Enhancing Neurogenesis of Neural Stem Cells Using Homogeneous Nanohole Pattern-Modified Conductive Platform (2019)

Biocompatible platforms, wherein cells attach and grow, are important for controlling cytoskeletal dynamics and steering stem cell functions, including differentiation. Among various components, membrane integrins play a key role in focal adhesion of cells (18-20 nm in size) and are, thus, highly sensitive to the nanotopographical features of underlying substrates. Hence, it is necessary to develop a platform/technique that can provide high flexibility in controlling nanostructure sizes. We report a platform modified with homogeneous nanohole patterns, effective in guiding neurogenesis of mouse neural stem cells (mNSCs). Sizes of nanoholes were easily generated and varied using laser interference lithography (LIL), by changing the incident angles of light interference on substrates. Among three different nanohole patterns fabricated on conductive transparent electrodes, 500 nm-sized nanoholes showed the best performance for cell adhesion and spreading, based on F-actin and lamellipodia/filopodia expression. Enhanced biocompatibility and cell adhesion of these nanohole patterns ultimately resulted in the enhanced neurogenesis of mNSCs, based on the mRNAs expression level of the mNSCs marker and several neuronal markers. Therefore, platforms modified with homogeneous nanohole patterns fabricated by LIL are promising for the precise tuning of nanostructures in tissue culture platforms and useful for controlling various differentiation lineages of stem cells.
Direct Optimization of F-Measure for Retrieval-Based Personal Question Answering (2018)

Recent advances in spoken language technologies and the introduction of many customer facing products, have given rise to a wide customer reliance on smart personal assistants for many of their daily tasks. In this paper, we present a system to reduce users' cognitive load by extending personal assistants with long-term personal memory where users can store and retrieve by voice, arbitrary pieces of information. The problem is framed as a neural retrieval based question answering system where answers are selected from previously stored user memories. We propose to directly optimize the end-to-end retrieval performance, measured by the F1-score, using reinforcement learning, leading to better performance on our experimental test set(s).
Pressure-Dependent Leakage Detection Method Compared with Conventional Techniques (2011)

Various techniques have been developed for leakage detection. A relatively new approach pressure-dependent leakage detection (PDLD) has been developed as a modeling tool for identifying the leakage hotspots within the same framework as hydraulic model calibration. PDLD represents a leak as an emitter flow, the leakage detection model searches for emitter locations and coefficients such that the difference between the simulated and observed values (pressures and flows) is minimized. Two case studies, one in Thailand and the other in the UK, have been undertaken by using the PDLD method together with step-testing and acoustic noise logging devices, respectively. The results obtained with PDLD are compared with both device-based methods. The studies illustrate that the PDLD method is effective at identifying leakage hotspots regardless of pipe material and proves to be practical and useful for assisting the engineer to quickly find leaks in large water distribution systems.
Biosynthesis of IC202C, a New Siderophore with Immunosuppressive Activity. (2000)

In the course of our screening program for low molecular weight immunosuppressive compounds, IC202A (1), B (2)
Modelling the influence of UV curing strategies for optimisation of inkjet based 3D printing (2021)

A predictive model is developed to assist in the design and manufacture of structures by inkjet based 3D printing (IJ3DP)/additive manufacturing. IJ3DP often exploits photopolymerisation to rapidly convert a photoreactive liquid ink into a solid product. Unfortunately, deviations from the intended design and product performance are often observed and a lack of understanding of the underlying processes and their interactions prevents users from resolving these issues. We develop and validate a predictive model that incorporates the critical processing parameters, including UV source pathway, UV intensity, printing strategy, and interlayer attenuation, such that we are able to predict the degree of ink conversion throughout the product. We show how this model can then be used to guide users by demonstrating the coupling of this description with a cost model and illustrating how printing strategy affects descriptors of both the quality and cost of production.
Data from Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Although enzalutamide (ENZ) has been widely used to treat &lt;i&gt;de novo&lt;/i&gt; or castration-resistant metastatic prostate cancer, resistance develops and disease progression is ultimately inevitable. There are currently no approved targeted drugs to specifically delay or overcome ENZ resistance.&lt;/p&gt;Experimental Design:&lt;p&gt;We selected several ENZ-resistant cell lines that replicated clinical characteristics of the majority of patients with ENZ-resistant disease. A high-throughput pharmacologic screen was utilized to identify compounds with greater cytotoxic effect for ENZ-resistant cell lines, compared with parental ENZ-sensitive cells. We validated the potential hits &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;, and used knockdown and overexpression assays to study the dependencies in ENZ-resistant prostate cancer.&lt;/p&gt;Results:&lt;p&gt;ABT199 (BCL-2 inhibitor) and IMD0354 (IKKB inhibitor) were identified as potent and selective inhibitors of cell viability in ENZ-resistant cell lines &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; which were further validated using loss-of-function assays of BCL-2 and IKKB. Notably, we observed that overexpression of BCL-2 and IKKB in ENZ-sensitive cell lines was sufficient for the emergence of ENZ resistance. In addition, we confirmed that BCL-2 or IKKB inhibitors suppressed the development of ENZ resistance in xenografts. However, validation of both BCL-2 and IKKB in matched castration-sensitive/resistant clinical samples showed that, concurrent with the development of ENZ/abiraterone resistance in patients, only the protein levels of IKKB were increased.&lt;/p&gt;Conclusions:&lt;p&gt;Our findings identify BCL-2 and IKKB dependencies in clinically relevant ENZ-resistant prostate cancer cells &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;, but indicate that IKKB upregulation appears to have greater relevance to the progression of human castrate-resistant prostate cancer.&lt;/p&gt;&lt;/div&gt;
Conformational analysis of an opioid peptide in solvent media that mimic cytoplasm viscosity (1992)

Many neuropeptides exert their action between the presynaptic vesicles and postsynaptic transmembrane receptors, crossing different layers of specialized cytoplasm. Biomimetic media usually employed to study bioactive peptides do not reproduce the physico chemical environment of cytoplasm--in particular, the high viscosity of this biological fluid. Here we describe a conformational study of a delta-selective opioid peptide, deltorphin I, at variable temperatures in several biocompatible media characterized by varying values of viscosity and dielectric constant. It was found that only viscosity, among these parameters, induces ordered conformations; that is, it acts as a conformational sieve. This finding suggests that the high viscosity of the intersynaptic fluid contributes, in addition to the membrane catalysis proposed by Schwyzer, in overcoming the so-called entropic barrier to the transition state of peptide-receptor interaction by selecting ordered conformations prior to receptor interaction. The folded conformer found in the 80:20 (v:v) DMSOd6/H2O cryoprotective mixture at 265 K has a shape consistent with those of rigid nonpeptidic opiates.
Data Recovery on Encrypted Databases with k-Nearest Neighbor Query Leakage (2019)

Recent works by Kellaris et al. (CCS'16) and Lacharite et al. (SP'18) demonstrated attacks of data recovery for encrypted databases that support rich queries such as range queries. In this paper, we develop the first data recovery attacks on encrypted databases supporting one-dimensional k-nearest neighbor (k-NN) queries, which are widely used in spatial data management. Our attacks exploit a generic k-NN query leakage profile: the attacker observes the identifiers of matched records. We consider both unordered responses, where the leakage is a set, and ordered responses, where the leakage is a k-tuple ordered by distance from the query point. As a first step, we perform a theoretical feasibility study on exact reconstruction, i.e., recovery of the exact plaintext values of the encrypted database. For ordered responses, we show that exact reconstruction is feasible if the attacker has additional access to some auxiliary information that is normally not available in practice. For unordered responses, we prove that exact reconstruction is impossible due to the infinite number of valid reconstructions. As a next step, we propose practical and more realistic approximate reconstruction attacks so as to recover an approximation of the plaintext values. For ordered responses, we show that after observing enough query responses, the attacker can approximate the client's encrypted database with considerable accuracy. For unordered responses we characterize the set of valid reconstructions as a convex polytope in a k-dimensional space and present a rigorous attack that reconstructs the plaintext database with bounded approximation error. As multidimensional spatial data can be efficiently processed by mapping it to one dimension via Hilbert curves, we demonstrate our approximate reconstruction attacks on privacy-sensitive geolocation data. Our experiments on real-world datasets show that our attacks reconstruct the plaintext values with relative error ranging from 2.9% to 0.003%.
Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H Spike mutations in Uruguay (2021)

Abstract Uruguay was able to control the viral dissemination during the first nine months of the SARS-CoV-2 pandemic. Unfortunately, towards the end of 2020, the number of daily new cases exponentially increased. Herein we analyzed the country-wide genetic diversity of SARS-CoV-2 between November, 2020 and April, 2021. Our findings identified that the most prevalent viral variant during late 2020 was a B.1.1.28 sublineage carrying mutations Q675H+Q677H in the viral Spike, now designated as lineage P.6. This new lineage P.6 probably arose around November 2020, in Montevideo, Uruguay’s capital department and rapidly spread to other Uruguayan departments, with evidence of further local transmission clusters, also spread sporadically to the USA and Spain. The Q675H and Q677H mutations are in the proximity of the polybasic cleavage site at the S1/S2 boundary and also arose independently in many SARS-CoV-2 lineages circulating worldwide. Although the lineage P.6 was replaced by the Variant of Concern (VOC) P.1 as the predominant viral strain in Uruguay since April 2021, the monitoring of the concurrent emergence of Q675H+Q677H in VOCs should be of worldwide interest.
Mechanically Controlled Quantum Contact With On-Chip MEMS Actuator (2007)

We report fabrication and characterization of a mechanically controlled quantum point contact with on-chip electrostatic actuators. Two metallic tips separated with a nano gap are integrated with a micro mechanism, which can be actuated by applied voltage. The electrostatic actuation of the micro mechanism allows the control of separation gap at nanometer level. The gap variation at nanometer level is calibrated with the devices operated in transmission electron microscope. Furthermore, performance of the device is demonstrated by measuring conductance quantization while separating the tips in contact as well as electrical measurements by using tips coated with self assembled monolayers (1-4 benzene dithiol) and conjugated Ru complex
CD/PMD-Insensitive optical performance monitoring of OSNR degradation in an 80-Gb/s pol-muxed RZ-DPSK system (2008)

We experimentally demonstrate an OSNR monitoring technique for 80-Gb/s polarization-multiplexed RZ-DPSK utilizing narrowband optical filter and RF spectrum analysis. Maximum RF power increment of 19.7 dB, insensitive to CD and PMD, is measured for monitoring of OSNR up to 27 dB.
<title>New block coding method for bilevel images</title> (1995)

A new block coding technique for the compression of bilevel text images is presented. The technique uses a combination of pre-processing the image to extract the edge information and block coding to compress the data. The key feature of the technique is simplicity in implementation. The pre-processing consists of an image differencing operation to decorrelate the strings of black pixels. The decorrelation is followed by the lossless coding of each block of the image. The performance of the new image differencing method is examined based on both theoretical and experimental code length data. Both theoretical and simulation results show that by pre-processing the image, the number of nonzero pixels can be significantly reduced and a more efficient block code is realized.
Identification of mutations in the putative ATP-binding domain of the adrenoleukodystrophy gene. (1994)

The recently identified adrenoleukodystrophy (ALD) gene is predicted to encode a peroxisomal protein of 745 amino acids that includes one domain for ATP-binding, termed nucleotide-binding fold (NBF). To determine whether mutations occur in the putative NBF of ALD protein, we analyzed by denaturing gradient gel electrophoresis (DGGE) exon 6 and 8 that encode most part of this domain in 50 ALD patients. Four amino acid substitutions, three frameshift mutations leading to premature termination signal, and a splicing mutation were identified. These amino acid substitutions occurred at residues highly conserved in other ATP-binding cassette (ABC) proteins. In addition, a nonsense mutation was detected in exon 4.
SiPM based preclinical PET/MR insert for a human 3T MR: first imaging experiments (2011)

Simultaneous PET/MRI is a hybrid imaging modality which promises to play an important role in the field of molecular imaging, as it combines the outstanding soft-tissue contrast of MRI with the metabolic and functional information of PET and MRI. In addition, the possibility for true simultaneous acquisition allows for improved 4D registration which in due course may lead to enhanced image quality and image quantification. The main technical challenges of simultaneous PET/MR are the MR-based attenuation correction and the development of an MR-compatible PET detector technology. Avalanche photo diode based detectors have been already successfully integrated into preclinical as well as human systems [1,2]. Low but noticeable interferences between PET and MRI have been reported so far. Unfortunately, these implementations do not offer the measurement of time of flight (TOF) information in the sub-ns range, which is one of the drivers for high quality clinical PET and has been state-of-the-art in clinical PET/CT for the last 5 years.
B39 The Effect Of Huntingtin Gene Cag Repeat Expansion On Human Induced Pluripotent Stem Cell Neuronal Differentiation (2014)

<h3></h3> Cell therapy is a key strategy in regenerative medicine to replace damaged tissues, and is a viable approach for treating Huntington’s disease (HD) where specific degeneration of striatal GABAergic medium spiny neurons (MSNs) occurs as a consequence of expansion of the CAG repeats region of the htt gene. Implementation of cell replacement strategies using pluripotent stem cells requires development and characterisation of new differentiation protocols as previously described protocols are long and produce MSNs at a low efficiency. In this study we use a recently developed neuronal differentiation protocol which generates a significant level of MSN-like neurons from human embryonic stem cells, and apply it to induced pluripotent stem cell (iPSC) lines derived from HD and control patients. We characterise the progress of the iPSC lines through differentiation at the protein level by immunocytochemistry, and at the gene expression level using a customised quantitative PCR platform that monitors expression of 112 genes specific for neural developmental stages and/or encephalic areas. At the later stages of the protocol we assess functionality of the neurons. We observe clear differences in the rate at which different iPSC lines progress through differentiation with each cell line displaying a different gene expression profile. Some of the iPSC lines produce neurons expressing key MSN markers to a lesser or greater extent, with calcium signalling imaging indicating that this protocol generates a high number of functional neurons. Our results show that this differentiation protocol generates MSNs at a level comparable to or better than previously described protocols in a shorter time. Also we observe that CAG repeat expansion alters the rate of iPSC differentiation as well as potentially influencing MSN development and functionality.
Test results for a Bi-2223 HTS racetrack coil for generator applications (1996)

Testing, results and analysis of a Bi-2223 model superconducting generator coil produced under the DOE Superconductivity Partnership Initiative are presented. The test arrangement enables coil energization with dc and transient currents over a range of operating temperatures to explore coil performance under conditions analogous to those that would be experienced by a superconducting generator field coil. Analytical calculations of coil ac and ohmic losses and temperature rise compare well with experimental measurements. Good performance is predicted for a typical 3-phase fault condition. Coil steady state and transient performance can be predicted with confidence for full scale superconductor application.
An In Vivo Covalent TMP-Tag Based on Proximity-Induced Reactivity (2009)

Chemical tags for live cell imaging are emerging as viable alternatives to the fluorescent proteins for labeling proteins with small molecule probes. Among reported chemical tags, trimethoprim (TMP)-tag stands out for having sufficient cell permeability and selectivity to allow imaging of intracellular proteins. TMP-tag provides a noncovalent label in which the protein of interest is fused to E. coli dihydrofolate reductase (DHFR) and then labeled with a cell-permeable TMP-probe heterodimer. To complement the utility of the noncovalent TMP-tag, we sought to render the TMP-tag covalent for applications such as single-molecule tracking and pulse-chase labeling that would benefit from a more permanent modification. On the basis of the long-standing use of proximity-induced reactivity for irreversible inhibitor design and its more recent application to in vitro chemical biology tools, we designed an eDHFR variant with a unique cysteine residue positioned to react with an acrylamide electrophile installed on the TMP-probe label. In vitro experiments show that the eDHFR:L28C nucleophile reacts rapidly and quantitatively with the TMP-acrylamide-probe. Most significantly, the balance in reactivity provided by the acrylamide electrophile allows intracellular proteins tagged with eDHFR:L28C to be labeled with a TMP-acrylamide-fluorescein heterotrimer in live cells with minimal background. Thus, the TMP electrophile described here can be used immediately as a covalent chemical tag in live cells. Moreover, proximity-induced reactivity is shown to be sufficiently selective for use in a living cell, suggesting a general approach for the development of orthogonal covalent chemical tags from existing noncovalent ligand-protein pairs.