gebhart/patrepeval huggingface dataset:
Highly Conductive Crystals Prepared by Electrocrystallization of Potassium Dicyanophthalocyaninatoiron(III) (1987)

Abstract Inherently conductive (0.4 S.cm−1) crystals of cyanophthalocyaninatoiron(III) were prepared by electrocrystallization of potassium dicyanophthalocyaninatoiron(III) in acetonitrile. This crystal was suggested to have a three-dimensional interplaner overlapping of π-orbitals by X-ray diffraction.
A mechanical model of precursory source processes for some large earthquakes (1982)

A mechanical model is presented of precursory source processes for some large earthquakes along plate boundaries. It is assumed that the pre‐seismic period consists of the upward progression of a zone of slip from lower portions of the lithosphere towards the Earth's surface. The slip front is blocked by local asperities of different size and strength; these asperities may be zones of real alteration of inherent strength, or instead may be zones which are currently stronger due to a local slowdown of a basically rate‐dependent frictional response. Such blocking by a single, large asperity, or array of asperities, produces quiescence over a segment of plate boundary, until gradual increase of the stress concentration forces the slip zone through the blocked region at one end of the gap, thus nucleating a seismic rupture that propagates upwards and towards the other end. This model is proposed to explain certain distinctive seismicity patterns that have been observed before large earthquakes, notably quiescence over the gap zone followed by clustering at its ends prior to the main event. A discussion of mechanical factors influencing the process is presented and some introductory modelling, performed with the use of a generalized Elsasser model for lithospheric plates and the "line spring" model for part‐through flaws (slip zones) at plate boundaries, is outlined briefly.
Treatment Options in Nodular Lymphocyte-Predominant Hodgkin Lymphoma (2013)

SUMMARY Nodular lymphocyte-predominant Hodgkin lymphoma accounts for approximately 5% of all Hodgkin lymphoma cases. Although this entity is characterized by immunohistological and clinical features such as a consistent expression of CD20 on the malignant lymphocyte-predominant cells and a more indolent clinical course resembling indolent non-Hodgkin lymphoma, treatment is often similar to classical Hodgkin lymphoma. Other approaches appear possible but data are scarce. Especially the ultimate role of anti-CD20 antibodies, the optimal first-line chemotherapy protocol and the value of high-dose chemotherapy followed by autologous stem cell transplantation in relapsed disease are undefined to date. The present article aims at summarizing and discussing the most recent publications on treatment options in nodular lymphocyte-predominant Hodgkin lymphoma.
Induction of Protective and Specific Antibodies against Cocaine by Intranasal Immunisation Using a Glyceride Adjuvant (2005)

The goal of this study was to investigate an intranasal cocaine vaccine containing the mucosal adjuvant macrogol-6-glycerol capylocaprate (RhinoVax). Cocaine-KLH conjugate was prepared and administered in two formulations. Ten mice were immunised intranasally using RhinoVax as adjuvant and ten subcutaneously using aluminium hydroxide as an adjuvant. A negative control group (n=10) received unconjugated KLH with RhinoVax intranasally. Specific cocaine antibodies in serum were measured following primary and booster immunisation. Relative antibody responses in serum indicated that the immunisation was successful. Animals were then challenged with cocaine either intranasally or intraperitoneally with subsequent measurement of drug distribution into the serum, brain and olfactory bulb. The cocaine-immunised groups revealed significantly lower cocaine levels in the brain compared to the negative control group. The inhibition of cocaine distribution to the brain in the intranasal immunised group was comparable to that of the subcutaneous immunised group. This was unexpected because the cocaine specific antibody levels in serum were fivefold lower in the intranasal immunised group. However, the presence of mucosal cocaine specific antibodies after intranasal immunisation could play an important role in hindering direct access of cocaine into the brain via the olfactory bulb.
Combination absorption and fluorescence for detection of vessels in intestinal sub-mucosa (Conference Presentation) (2018)

Injuries to main vascular structures within the sub mucosa present a serious complication during surgery. There is no evidence-based treatment to prevent this type of injury, so detection is critical. Using a combination of absorption and fluorescence imaging we can detect blood vessel phantoms to a depth of 7 mm in intestinal sub-mucosa. Using an illumination source at 850, and reading the cross-polarized reflected signal also at 850 gives the absorption image. Simultaneous excitation of ICG at 785 nm creates a fluorescent response that is used for contrast enhancement.
17O NMR spectroscopic study of substituted 9‐fluorenones (1991)

Abstract The 17 O NMR chemical shift data for 23 9‐fluorenones in acetonitrile at 75°C are reported. 17 O NMR data for the 3‐substituted 9‐fluorenones are correlated with 17 O NMR data for 4‐substituted acetophenones. Chemical shift data for 1‐halogeno‐9‐fluorenones are deshielded relative to the 3‐isomers, suggesting important repulsive van der Waals interactions. The keto carbonyl signal for 9‐fluorenone‐1‐carboxylic acid is substantially shielded, as expected, from intramolecular hydrogen bonding. The data for several multi‐substituted 9‐fluorenones demonstrate that substituent effects are additive for the 9‐fluorenones.
Multicenter clinical trial of the conformable stent graft for the treatment of acute, complicated type B dissection (2015)

Treatment with the conformable thoracic endovascular aortic repair device produced favorable perioperative and intermediate level clinical and anatomic outcomes. In particular, an operative mortality of 8% in this cohort is comparable to that noted in a Society for Vascular Surgery objective performance criteria publication. Late survival in our cohort compares favorably with historical data referable to complicated type B dissection.
ChemInform Abstract: Azido Glycols: Potent, Low Molecular Weight Renin Inhibitors Containing an Unusual Post Scissile Site Residue. (1989)

Abstract Basic hydrolysis of the oxazolidinone (I) followed by N‐protection produces the allylic alcohol (IIb) which is converted to the diol (IV) by hydroboration.
Association mapping in sunflower (Helianthus annuus L.) reveals independent control of apical vs. basal branching (2015)

In sunflower, variation in branching is genetically complex and overall branching patterns (i.e., apical vs. basal) were found to be influenced by distinct genomic regions. Moreover, numerous candidate branching genes mapped in close proximity to significant branching associations. Although the sunflower genome exhibits localized islands of elevated linkage disequilibrium (LD), these non-random associations are known to decay rapidly elsewhere. The subset of candidate genes that co-localized with significant associations in regions of low LD represents the most promising target for future functional analyses.
Selective catalytic reduction of NOx with NH3: opportunities and challenges of Cu-based small-pore zeolites (2021)

Zeolites, as efficient and stable catalysts, are widely used in the environmental catalysis field. Typically, Cu-SSZ-13 with small-pore structure shows excellent catalytic activity for selective catalytic reduction of NO <i><sub>x</sub></i> with ammonia (NH<sub>3</sub>-SCR) as well as high hydrothermal stability. This review summarizes major advances in Cu-SSZ-13 applied to the NH<sub>3</sub>-SCR reaction, including the state of copper species, standard and fast SCR reaction mechanism, hydrothermal deactivation mechanism, poisoning resistance and synthetic methodology. The review gives a valuable summary of new insights into the matching between SCR catalyst design principles and the characteristics of Cu<sup>2+</sup>-exchanged zeolitic catalysts, highlighting the significant opportunity presented by zeolite-based catalysts. Principles for designing zeolites with excellent NH<sub>3</sub>-SCR performance and hydrothermal stability are proposed. On the basis of these principles, more hydrothermally stable Cu-AEI and Cu-LTA zeolites are elaborated as well as other alternative zeolites applied to NH<sub>3</sub>-SCR. Finally, we call attention to the challenges facing Cu-based small-pore zeolites that still need to be addressed.
Discovery of dually acting small-molecule inhibitors of cancer-resistance relevant receptor tyrosine kinases EGFR and IGF-1R (2016)

Small-molecule inhibitors of cancer-relevant receptor tyrosine kinases EGFR and IGF-1R have been discovered.
ChemInform Abstract: Molecular Recognition of Phosphate Esters: A Balance of Hydrogen Bonding and Proton Transfer Interactions. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Correction: Toxicity of metal–organic framework nanoparticles: from essential analyses to potential applications (2023)

Correction for 'Toxicity of metal-organic framework nanoparticles: from essential analyses to potential applications' by Romy Ettlinger <i>et al.</i>, <i>Chem. Soc. Rev.</i>, 2022, <b>51</b>, 464-484, https://doi.org/10.1039/D1CS00918D.
Embedded SoC Resource Manager to Control Temperature and Data Bandwidth (2007)

A 0.4mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> SoC resource manager controls operating frequency and allocates data bandwidth using various monitored information such as temperature, frequency of IP blocks and number of operations executed. Results show an increase of allowable temperature range by 30degC for real-time operations of two processor cores and two media processing cores. The design is fabricated in an 8M 90nm CMOS process
Structure and metal coordination of the diphosphane 2,2'-bis((diphenylphosphino)methyl)-1,1'-biphenyl ("BISBI") (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and metal coordination of the diphosphane 2,2'-bis((diphenylphosphino)methyl)-1,1'-biphenyl ("BISBI")Wolfgang A. Herrmann, Christian W. Kohlpaintner, Eberhardt Herdtweck, and Paul KiprofCite this: Inorg. Chem. 1991, 30, 22, 4271–4275Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/ic00022a032https://doi.org/10.1021/ic00022a032research-articleACS PublicationsRequest reuse permissionsArticle Views259Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Is Preoperative Gastritis Associated with Long-Term Outcome after Ileal Pouch-Anal Anastomosis (IPAA)? (2006)

Purpose: Ileal pouch-anal anastomosis (IPAA) has become the standard approach for patients with ulcerative colitis (UC) or indeterminate colitis (IC) requiring colectomy. Despite excellent functional results and high patient satisfaction, a significant proportion of patients develop pouchitis or Crohn's disease (CD) after surgery. The aim of this study was to assess whether preoperative gastritis is associated with acute pouchitis (AP), chronic pouchitis (CP), or CD development in UC or IC patients undergoing IPAA. Methods: UC or IC patients undergoing IPAA having preoperative EGD were identified. EGD reports were reviewed for evidence of macroscopic gastritis (erythema, erosions or friability). Gastric histology was classified into the following categories: normal, reactive gastropathy, chronic active gastritis, or focally enhanced gastritis. Patients were prospectively assessed for the development of clinical and endoscopically proven pouchitis (AP = antibiotic responsive; CP = antibiotic dependent or refractory to antibiotic therapy) or CD (afferent limb inflammation or pouch fistula onset). Results: The 84 patients (UC = 56, IC = 28) had a median age of 37 yrs (range, 9–78) and included 48 males (57%). Macroscopic gastritis was present in 55 patients (65%) and histologically detected in 57 patients (67%). Reactive gastropathy, chronic active gastritis, and focally enhanced gastritis were identified in 29%, 45%, and 19% of subjects, respectively. After a median follow-up of 12 months, AP was seen in 14 patients (17%), CP in 7 patients (8%) and CD developed in 6 patients (7%). Compared to patients with no gastritis, patients with macroscopic gastritis were not more likely to develop AP (18% vs. 17%, p= NS), CP (5% vs. 19%, p= 0.09), or CD (5% vs. 13%, p= NS). Similarly, patients with microscopic gastritis were not more likely to develop AP (18% vs. 18%, p= NS), CP (5% vs. 18%, p= 0.07) or CD (5% vs. 14%, p= NS). The presence of reactive gastropathy, chronic active gastritis, or focally enhanced gastritis was not associated with a higher incidence of AP, CP or CD after IPAA. The lack of association between gastritis and AP, CP and CD onset after IPAA was observed in both UC and IC patient subgroups. Conclusions: Preoperative gastritis is common in UC or IC patients. However, these findings are not associated with the development of acute pouchitis, chronic pouchitis or CD after IPAA.
Data for Suspended silicon waveguides for long-wave infrared wavelengths (2017)

This is the dataset used to create figures 2 and 4 on the paper: Soler Penades, J. et al (2017). Suspended silicon waveguides for long-wave infrared wavelengths. Optics Letters.
Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics (2022)

While advances in single cell genomics have helped to chart the cellular components of tumor ecosystems, it has been more challenging to characterize their specific spatial organization and functional interactions. Here, we combine single cell RNA-seq, spatial transcriptomics by Slide-seq, and <i>in situ</i> multiplex RNA analysis, to create a detailed spatial map of healthy and dysplastic colon cellular ecosystems and their association with disease progression. We profiled inducible genetic CRC mouse models that recapitulate key features of human CRC, assigned cell types and epithelial expression programs to spatial tissue locations in tumors, and computationally used them to identify the regional features spanning different cells in the same spatial niche. We find that tumors were organized in cellular neighborhoods, each with a distinct composition of cell subtypes, expression programs, and local cellular interactions. Comparing to scRNA-seq and Slide-seq data from human CRC, we find that both cell composition and layout features were conserved between the species, with mouse neighborhoods correlating with malignancy and clinical outcome in human patient tumors, highlighting the relevance of our findings to human disease. Our work offers a comprehensive framework that is applicable across various tissues, tumors, and disease conditions, with tools for the extrapolation of findings from experimental mouse models to human diseases.
1221: The Ecto-Atpase Inhibitor, ARL 67156, Induces Detrusor Overactivity by Enhancing Endogeneous ATP Activity in Rats (2005)

You have accessJournal of UrologyDiscussed Poster, Tuesday, May 24, 2005, 1:00 - 5:00 pm1 Apr 20051221: The Ecto-Atpase Inhibitor, ARL 67156, Induces Detrusor Overactivity by Enhancing Endogeneous ATP Activity in Rats Jun Nishiguchi, Yukio Hayashi, Hitoshi Masuda, Michael B. Chancellor, William C. de Groat, Naoki Yoshimura, and Hiromi Kumon Jun NishiguchiJun Nishiguchi More articles by this author , Yukio HayashiYukio Hayashi More articles by this author , Hitoshi MasudaHitoshi Masuda More articles by this author , Michael B. ChancellorMichael B. Chancellor More articles by this author , William C. de GroatWilliam C. de Groat More articles by this author , Naoki YoshimuraNaoki Yoshimura More articles by this author , and Hiromi KumonHiromi Kumon More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)35366-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1221: The Ecto-Atpase Inhibitor, ARL 67156, Induces Detrusor Overactivity by Enhancing Endogeneous ATP Activity in Rats." The Journal of Urology, 173(4S), p. 331 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 331 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Jun Nishiguchi More articles by this author Yukio Hayashi More articles by this author Hitoshi Masuda More articles by this author Michael B. Chancellor More articles by this author William C. de Groat More articles by this author Naoki Yoshimura More articles by this author Hiromi Kumon More articles by this author Expand All Advertisement PDF DownloadLoading ...
The Endogenous Balance of Soluble Tumor Necrosis Factor Receptors and Tumor Necrosis Factor Modulates Cachexia and Mortality in Mice Acutely Infected withTrypanosoma cruzi (1999)

To better understand the role of tumor necrosis factor (TNF) during Trypanosoma cruzi infection in BALB/c mice, we have investigated the kinetics of circulating tumor necrosis factor (TNF), soluble TNF receptor 1 (sTNR1), and sTNFR2 levels, as well as the interactions between such factors, in relation to parasitemia, cachexia, and mortality of acutely infected animals. Our data show that the parasitemic phase of T. cruzi infection in mice is associated with high levels of circulating TNF and sTNFR2, resulting in the formation of cytokine-receptor complexes and some degree of neutralization of TNF bioactivity. Although sTNR2 levels always exceeded TNF levels, low sTNFR/TNF circulating ratios were associated with cachexia in all infected mice, whereas the lowest ratios were observed in dying animals harboring the highest parasitemia. We also studied the modulation of sTNFR/TNF ratios induced by anti-TNF antibodies administered to infected animals and their consequences on the outcome of the infection. The injection of anti-TNF monoclonal antibody (MAb) TN3 into infected mice resulted in a paradoxical overproduction of TNF (associated with a higher parasitemia), lowered the sTNFR/TNF circulating ratios, and considerably worsened cachexia and mortality of animals. Another anti-TNF MAb (1F3F3) decreased the in vivo availability of TNF as well as parasite levels and reduced cachexia. Altogether, such results highlight that, besides playing a beneficial role early in infection, TNF also triggers harmful effects in the parasitemic phase, which are limited by the in vivo simultaneous endogenous production of soluble receptors.
ChemInform Abstract: Highly Diastereo‐ and Enantioselective CuH‐Catalyzed Synthesis of 2,3‐Disubstituted Indolines. (2015)

Abstract Cu‐catalyzed reductive cyclization of arylimines, derived from ortho‐amino styrenes, in the presence of (S,S)‐Ph‐BPE as chiral ligand constitutes a highly diastereo‐ and enantioselective synthesis of cis‐2,3‐disubstituted indolines.
Perineural versus lymphovascular invasion: Which is a better marker for unfavorable biochemical outcomes following prostatectomy? Results from the Duke Prostate Center Database. (2012)

34 Background: Despite a substantial effort to study the clinical significance of perineural invasion in prostate biopsies (PNIb) its prognostic significance remains controversial. The limited data on perineural invasion in radical prostatectomy (RP) specimens (PNIp) suggests that biopsy specimens inadequately represent whole gland pathology thus rendering investigation of PNIp even more clinically relevant. While lymphovascular invasion in pathology specimens (LVIp) has been more rigorously investigated, studies have shown conflicting results. More importantly, there has been minimal comparison of PNIp and LVIp in the same cohort to determine which marker is the superior prognostic factor. Methods: We retrospectively analyzed data from 1611 men who underwent RP from 1999 to 2010 from the Duke Prostate Center database. We evaluated PNIp and LVIp as predictors of time to BCR by comparing hazard ratios (HR) and 95% confidence intervals (CI) using crude and adjusted proportional hazards regression models that included both variables and controlled for demographic and clinico-pathological covariates. Results: A total of 1304 (81%) men had PNIp while only 82 (5%) men had LVIp. On crude regression, both PNIp (HR=3.39; 95% CI=1.94-5.84; p&lt;0.001) and LVIp (HR=2.33; 95% CI=1.49-3.64; p&lt;0.001) were significant predictors of adverse BCR risk. After adjusting for clinico-pathological covariates, PNIp remained significantly associated with increased BCR risk (HR=1.85; 95%CI =1.04-3.31; p=0.04). Specifically, men with PNIp were 85% more likely to experience BCR relative to PNIp (-) men. In contrast, LVIp was not independently associated with BCR risk (p=0.23). Conclusions: In a cohort of men who underwent RP, PNIp is predictive of adverse BCR outcomes independent of clinicopathological parameters that include LVIp. Consequently, LVIp is a poor predictor of BCR risk. PNIp may thus provide additional prognostic information for men treated with RP and its inclusion in predictive nomograms requires study. Further analyses to determine if PNIp is likewise associated with metastasis and cancer-specific survival are warranted.
Prototype Cold Weather Headwear (1974)

Abstract : Prototypes of an improved cold weather headgear ensemble have been developed which should provide protection from cold, wind, blowing snow, and frostbite in environments to -65F and 35 miles per hour wind velocities. The ensemble provides physical compatibility with military clothing and equipment and does not occlude the field of vision. The design covers the face, head and neck and is provided with features that permit achieving varying degrees of protection in response to varying severity of the environmental threat. The ensemble and its elements is composed largely of a helenca/urethane foam/cotton jersey laminate which provides excellent insulating properties, sound transparency, and permeability.