gebhart/patrepeval huggingface dataset:
Low complexity energy efficient joint transmission for OFDM multiuser downlinks (2005)

A specially favorable concept for interference reduction in future mobile radio systems consists in the application of joint detection in the uplink and joint transmission in the downlink. Concerning joint detection both optimum nonlinear and low complexity suboptimum linear signal processing algorithms are well known. This is not the case for joint transmission, where up to now most research work focuses on linear signal processing algorithms, which are dual to the ones applied for joint detection. In the present paper a novel signal processing algorithm for joint transmission, termed transmit nonlinear zero forcing, is presented. The main characteristic is the application of an unconventional multiply connected quantization scheme, which allows to improve the energy efficiency, i.e., for data symbols to be transmitted over channels with high attenuations without introducing excessive interferences. Especially in scenarios with large gain differences of the channels between the access point and individual mobile terminals said improved energy efficiencies allow a significant reduction of the required transmitted powers, a feature mitigating intercell interference in cellular systems and thereby enhancing system capacity. In practical systems such gain differences, due to shadowing and largely different distances between the access point and the mobile terminals, prevail.
Synthèse et caractérisation de polymères fonctionnalisés et de copolymères à base de méthylidene malonate 2. 1. 2. : application à la vectorisation de principes actifs (2001)

Le present travail a consiste a mettre au point une nouvelle gamme de copolymeres a blocs a base d'un polymere bioerodable, le methylidene malonate 2. 1. 2. La qualite de la vectorisation d'un principe actif dans l'organisme conditionnant l'efficacite de l'acte therapeutique, notre objectif a ete d'adapter au mieux la composition chimique et la structure du principe actif, qu'il soit hydrophobe ou charge comme l'ADN. La premiere partie de ce manuscrit a ete consacree a un rappel des concepts generaux de la Sectorisation. Nous avons decrit les principaux systemes colloidaux et biopolymeres developpes a l'heure actuelle, ainsi que les recents progres effectues en vectorisation notamment en termes de ciblage cellulaire actif. Par ailleurs, nous avons montre dans quelles mesures les polymeres dits sont adaptes a la vectorisation d'ADN. Dans une deuxieme partie, nous avons decrit la synthese par voie anionique de copolymeres a blocs poly(methylidene malonate 2. 1. 2)-b-poly(oxyde d'ethylene) fonctionnalises par une fonction chimique reactive. Introduite lors de l'amorcage de la polymerisation, cette extremite reactive peut servir ulterieurement de site d'ancrage pour une molecule pilote, facilitant ainsi la reconnaissance de la particule par des recepteurs de la cellule cible. Nous avons ensuite etudie la transformation chimique de cette fonctionnalite en une autre fonction chimique ainsi que son couplage avec differents types de ligands. Nous avons notamment selectionne un derive saccharidique, une vitamine, des peptides ainsi qu'un marqueur, la fluoresceine, lequel permet de visualiser les particules in vitro. L'etude de la micellisation de ces copolymeres a revele que les copolymeres fonctionnalises suivent globalement le modele theorique de Zhulina-Birshtein et que la nature de la fonctionnalite a peu d'incidence sur le diametre moyen des micelles. Enfin, nous avons propose la synthese de nouveaux copolymeres canoniques sequences a base de poly(methylidene malonate 2. 1. 2) et d'un polymere canonique, le poly(methacrylate de 2-dimethylaminoethyle). Ces derniers ont ete prepares en associant deux techniques de polymerisation, la polymerisation par transfert de groupe et la polymerisation zwitterionique. Ces differents copolymeres ont ensuite ete utilises pour la formulation de micelles mixtes et thermosensibles, et de nanoparticules.
Comparative influence of load versus inotropic states on indexes of ventricular contractility: experimental and theoretical analysis based on pressure-volume relationships. (1987)

We examined the quantitative influence of carefully controlled alterations in end-diastolic volume and afterload resistance on multiple simultaneously determined ejection and isovolumetric phase indexes of left ventricular contractile function in 23 isolated supported canine ventricles. The influence of load change on each index was compared with its sensitivity to inotropic stimulation, and this sensitivity was in turn contrasted to the response of the end-systolic pressure-volume relationship (ESPVR). Experimental data demonstrated various degrees of load sensitivity among the indexes, with a generally curvilinear relationship between load and index response for both preload and afterload alterations. The curvilinear nature of these relationships meant that over a select range of loading, many indexes demonstrated relative load independence. They also often displayed greater sensitivity to inotropic change than the ESPVR, and both factors help explain their enduring clinical utility. To further explore the influence of load and contractile state on several of the indexes, we developed a theoretical analysis, using variables common to pressure-volume relationships, in which these dependencies could be derived. The theoretical models fit very well with the experimental data, and reaffirmed the frequently curvilinear nature of the relationships. We conclude that while many clinical indexes of ventricular contractile function show significant load dependence, the information they provide can be reasonably interpreted within defined ranges of load and inotropic alteration. Any advantage of the ESPVR will derive not from the magnitude of its response to inotropic change, which is smaller than most other indexes, but from its relative insensitivity to load alteration over a wider range of load.
Characterization of Mesenchymal Stem Cells Derived from Patients with Cerebellar Ataxia: Downregulation of the Anti-Inflammatory Secretome Profile (2020)

Mesenchymal stem cell (MSC) therapy is a promising alternative approach for the treatment of neurodegenerative diseases, according to its neuroprotective and immunomodulatory potential. Despite numerous clinical trials involving autologous MSCs, their outcomes have often been unsuccessful. Several reports have indicated that MSCs from patients have low capacities in terms of the secretion of neurotrophic or anti-inflammatory factors, which might be associated with cell senescence or disease severity. Therefore, a new strategy to improve their capacities is required for optimal efficacy of autologous MSC therapy. In this study, we compared the secretory potential of MSCs among cerebellar ataxia patients (CA-MSCs) and healthy individuals (H-MSCs). Our results, including secretome analysis findings, revealed that CA-MSCs have lower capacities in terms of proliferation, oxidative stress response, motility, and immunomodulatory functions when compared with H-MSCs. The functional differences were validated in a scratch wound healing assay and neuron-glia co-cultures. In addition, the neuroprotective and immunoregulatory protein follistatin-like 1 (FSTL1) was identified as one of the downregulated proteins in the CA-MSC secretome, with suppressive effects on proinflammatory microglial activation. Our study findings suggest that targeting aspects of the downregulated anti-inflammatory secretome, such as FSTL1, might improve the efficacy of autologous MSC therapy for CA.
Effect of terminal functional group size on ferroelectric and antiferroelectric properties of liquid crystals (2005)

Through the incorporation of sterically hindering, bulky terminal groups into the structures of chiral and racemic smectic liquid‐crystalline materials, we sought to interfere with, and decouple, the layers of various mesophases. By varying the size of the terminal group we found that we could control the mesophase structure, and to some degree its physical properties. In this article we present textural and X‐ray data which give insights into the structures of the mesophases.
4D point cloud registration for tumor vascular networks monitoring from ultrasensitive Doppler images (2019)

International audience
Cover Feature: Ferrocenyl‐Pyrenes, Ferrocenyl‐9,10‐Phenanthrenediones, and Ferrocenyl‐9,10‐Dimethoxyphenanthrenes: Charge‐Transfer Studies and SWCNT Functionalization (Chem. Eur. J. 12/2020) (2019)

Charge-transfer studies and single-walled carbon nanotubes (SWCNTs) functionalization of a series of ferrocenyl-functionalized pyrenes and phenanthrenes is reported. Their solid-state structures confirm that they are able to form π–π interactions, which was further proven by DFT calculations and disentangling experiments with SWCNTs. These nanoconjugates show reversible ferrocenyl-based redox processes. More information can be found in the Full Paper by H. Lang et al. on page 2635.
ChemInform Abstract: Divalent Samarium‐Induced Cyclopropanation of Lithium Enolates. A One‐ Pot Synthesis of Cyclopropanols from Ketones. (1987)

Abstract Acetophenone (Ia) and propiophenone (Ib) are converted to the lithium enolates (II) which react with diiodomethane (III) in the presence of samarium diiodide, yielding the cyclopropanols (IV).
Modeling of a Segmented Electrode for Desynchronizing Deep Brain Stimulation (2011)

Deep brain stimulation (DBS) is an effective therapy for medically refractory movement disorders like Parkinson's disease. The electrodes, implanted in the target area within the human brain, generate an electric field which activates nerve fibers and cell bodies in the vicinity. Even though the different target nuclei display considerable differences in their anatomical structure, only few types of electrodes are currently commercially available. It is desirable to adjust the electric field and in particular the volume of tissue activated around the electrode with respect to the corresponding target nucleus in a such way that side effects can be reduced. Furthermore, a more selective and partial activation of the target structure is desirable for an optimal application of novel stimulation strategies, e.g., coordinated reset neuromodulation. Hence we designed a DBS electrode with a segmented design allowing a more selective activation of the target structure. We created a finite element model (FEM) of the electrode and analyzed the volume of tissue activated for this electrode design. The segmented electrode activated an area in a targeted manner, of which the dimension and position relative to the electrode could be controlled by adjusting the stimulation parameters for each electrode contact. According to our computational analysis, this directed stimulation might be superior with respect to the occurrence of side effects and it enables the application of coordinated reset neuromodulation under optimal conditions.
SemiSPECT: A small‐animal single‐photon emission computed tomography (SPECT) imager based on eight cadmium zinc telluride (CZT) detector arrays (2006)

The first full single-photon emission computed tomography (SPECT) imager to exploit eight compact high-intrinsic-resolution cadmium zinc telluride (CZT) detectors, called SemiSPECT, has been completed. Each detector consists of a CZT crystal and a customized application-specific integrated circuit (ASIC). The CZT crystal is a 2.7 cm x 2.7 cm x -0.2 cm slab with a continuous top electrode and a bottom electrode patterned into a 64 x 64 pixel array by photolithography. The ASIC is attached to the bottom of the CZT crystal by indium-bump bonding. A bias voltage of -180 V is applied to the continuous electrode. The eight detectors are arranged in an octagonal lead-shielded ring. Each pinhole in the eight-pinhole aperture placed at the center of the ring is matched to each individual detector array. An object is imaged onto each detector through a pinhole, and each detector is operated independently with list-mode acquisition. The imaging subject can be rotated about a vertical axis to obtain additional angular projections. The performance of SemiSPECT was characterized using 99mTc. When a 0.5 mm diameter pinhole is used, the spatial resolution on each axis is about 1.4 mm as estimated by the Fourier crosstalk matrix, which provides an algorithm-independent average resolution over the field of view. The energy resolution achieved by summing neighboring pixel signals in a 3 x 3 window is about 10% full-width-at-half-maximum of the photopeak. The overall system sensitivity is about 0.5 x 10(-4) with the energy window of +/-10% from the photopeak. Line-phantom images are presented to visualize the spatial resolution provided by SemiSPECT, and images of bone, myocardium, and human tumor xenografts in mice demonstrate the feasibility of preclinical small-animal studies with SemiSPECT.
Transcripts Targeted by the MicroRNA-16 Family Cooperatively Regulate Cell Cycle Progression (2007)

microRNAs (miRNAs) are abundant, approximately 21-nucleotide, noncoding regulatory RNAs. Each miRNA may regulate hundreds of mRNA targets, but the identities of these targets and the processes they regulate are poorly understood. Here we have explored the use of microarray profiling and functional screening to identify targets and biological processes triggered by the transfection of human cells with miRNAs. We demonstrate that a family of miRNAs sharing sequence identity with miRNA-16 (miR-16) negatively regulates cellular growth and cell cycle progression. miR-16-down-regulated transcripts were enriched with genes whose silencing by small interfering RNAs causes an accumulation of cells in G(0)/G(1). Simultaneous silencing of these genes was more effective at blocking cell cycle progression than disruption of the individual genes. Thus, miR-16 coordinately regulates targets that may act in concert to control cell cycle progression.
pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) s (1999)

This article is hosted on a website external to the CBCRA Open Access Archive. Selecting “View/Open” below will launch the full-text article in another browser window.
Frequency Stabilized Mode Locked Laser with 1000 Finesse Intracavity Etalon (2009)

A low noise, frequency stabilized, semiconductor based, 10.287 GHz mode-locked laser with 1000 finesse intracavity etalon is demonstrated with a timing jitter (1Hz – 100MHz) of 10.9 fs and optical frequency fluctuations less than 150 kHz.
Perfluoroalkylated fatty acid monoesters of trehalose and sucrose for biomedical applications: Remarkable emulsifying properties of 6‐O‐[3′‐(perfluorooctyl) propanoyl]‐trehalose (1992)

A new series of perfluoroalkylated fatty acid monoesters of α,α‐trehalose and sucrose has been evaluated with respect to their physicochemical and biological properties for possible biomedical use. These water‐soluble compounds strongly reduce the water surface tension and fluorocarbon/water interfacial tension. As co‐surfactants in perfluorodecalin/Pluronic F‐68 type emulsions they significantly increase the stability of these emulsions. Remarkably stable concentrated perfluorodecalin‐in‐water (50% w/v) emulsions were obtained when the C 8 F 17 CH 2 CH 2 C(O)‐α,α‐trehalose monoester was used as the sole surfactant, while no emulsion could be obtained with its maltoside analogue. No significant effect on the growth and viability of Namalva cell cultures and no hemolytic activity on human erythrocytes at concentrations up to 50 g/L were detected for these amphiphiles in spite of their high surface activity. The LD 50 was found to be in the range of 250–375 mg/kg of body weight i.v. in mice.
RNA-Mediated Gene Duplication: the Rat Preproinsulin I Gene Is a Functional Retroposon (1985)

Rats and mice have two, equally expressed, nonallelic genes encoding preproinsulin (genes I and II). Cytological hybridization with metaphase chromosomes indicated that both genes reside on rat chromosome I but are approximately 100,000 kilobases apart. In mice the two genes reside on two different chromosomes. DNA sequence comparisons of the gene-flanking regions in rats and mice indicated that the preproinsulin gene I has lost one of the two introns present in gene II, is flanked by a long (41-base) direct repeat, and has a remnant of a polydeoxyadenylate acid tract preceding the downstream direct repeat. These structural features indicated that gene I was generated by an RNA-mediated duplication-transposition event involving a transcript of gene II which was initiated upstream from the normal capping site. Sequence divergence analysis indicated that the pair of the original gene and its retroposed, but functional, counterpart (which appeared about 35 million years ago) is maintained by strong negative selection operating primarily on the segments encoding the chains of the mature hormone, whereas the segments encoding the parts of the polypeptide that are eliminated during processing and also the introns and the flanking regions are evolving neutrally.
Fast Algorithm of Unified Layer Performing Convolution and Average Pooling on the GPU (2019)

Recently ? Convolutional Neural Networks (CNN) have made a major contribution in the field of recognition. CNN has multiple convolution layers and convolution operations are needed large number of floating-point operations. So ? convolution operations are bottleneck of CNN. The main contribution of this paper is to present new methods for convolution and average pooling computation on the GPU. First ? we present fused filter method. An average pooling can be considered as a kernel. A convolution kernel and an average kernel can be fused. In fused filter method ? convolution using fused filter reduces floating-point operations for convolution and pooling computation. Also ? we present direct sum method. Convolution and average pooling computation are commutative. In direct sum method ? switching convolution and average pooling computation reduces floating point operations for convolution and pooling computation. Experimental results using NVIDIA V100 show direct sum method attains a speed-up factor of up to 1.8 (single precision) and 4.4 (half precision) over cuDNN naive implementation.
Bloch Surface Waves in Open Fabry–Perot Microcavities (2023)

Thanks to the increasing availability of technologies for thin film deposition, all-dielectric structures are becoming more and more attractive for integrated photonics. As light-matter interactions are involved, Bloch Surface Waves (BSWs) may represent a viable alternative to plasmonic platforms, allowing easy wavelength and polarization manipulation and reduced absorption losses. However, plasmon-based devices operating at an optical and near-infrared frequency have been demonstrated to reach extraordinary field confinement capabilities, with localized mode volumes of down to a few nanometers. Although such levels of energy localization are substantially unattainable with dielectrics, it is possible to operate subwavelength field confinement by employing high-refractive index materials with proper patterning such as, e.g., photonic crystals and metasurfaces. Here, we propose a computational study on the transverse localization of BSWs by means of quasi-flat Fabry-Perot microcavities, which have the advantage of being fully exposed toward the outer environment. These structures are constituted by defected periodic corrugations of a dielectric multilayer top surface. The dispersion and spatial distribution of BSWs' cavity mode are presented. In addition, the hybridization of BSWs with an A exciton in a 2D flake of tungsten disulfide (WS<sub>2</sub>) is also addressed. We show evidence of strong coupling involving not only propagating BSWs but also localized BSWs, namely, band-edge and cavity modes.
Evidence against Linkage of von Recklinghausen Neurofibromatosis and Chromosome 19 Markers (1986)

In this paper we report the study of the segregation of three chromosome 19 markers known to be linked to myotonic dystrophy in nine families with von Recklinghausen neurofibromatosis. Clear evidence against linkage was found for all three markers excluding the von Recklinghausen neurofibromatosis gene from the myotonic dystrophy region of chromosome 19.
Efficient Multispin Homonuclear Double-Quantum Recoupling for Magic-Angle Spinning NMR:  13C−13C Correlation Spectroscopy of U-13C-Erythromycin A (1998)

We introduce a radio frequency (rf) pulse sequence for efficient homonuclear double-quantum dipolar recoupling under magic-angle spinning NMR. The sequence is optimized for two-dimensional double-quantum 13C−13C chemical shift correlation spectroscopy in multiple spin systems, such as the U-13C-labeled antibiotic erythromycin A. Spin systems such as this display a wide range of isotropic and anisotropic chemical shifts and, therefore, require a broadband dipolar recoupling sequence that minimizes the errors arising from the interaction of chemical shifts and rf inhomogeneity. The sequence should also preserve the theoretical efficiency over the powder average (∼73%) provided by the C7 experiment of Levitt and co-workers (Lee, Y. K.; Kurur, N. D.; Helmle, M.; Johannessen, O. G.; Nielsen, N. C.; Levitt, M. H. Chem. Phys. Lett. 1995, 242, 304−309). We satisfy these criteria by combining the standard C7 (2πφ−2πφ+180) elements with π-pulse permuted elements (πφ−2πφ+180−πφ, in analogy to the MLEV decoupling scheme) to remove error terms over a ±10% range of rf amplitude. The new sequence, which we refer to as CMR7 (combined MLEV refocusing and C7), yields for two-spin systems broadband double-quantum filtering efficiencies greater than 70%. For multispin systems, the improved polarization transfer efficiency results in greater cross-peak intensities, facilitating assignment of U-13C-labeled molecules in the solid state.
N-Terminal Labeling of Filamentous Phage To Create Cancer Marker Imaging Agents (2012)

We report a convenient new technique for the labeling of filamentous phage capsid proteins. Previous reports have shown that phage coat protein residues can be modified, but the lack of chemically distinct amino acids in the coat protein sequences makes it difficult to attach high levels of synthetic molecules without altering the binding capabilities of the phage. To modify the phage with polymer chains, imaging groups, and other molecules, we have developed chemistry to convert the N-terminal amines of the ~4200 coat proteins into ketone groups. These sites can then serve as chemospecific handles for the attachment of alkoxyamine groups through oxime formation. Specifically, we demonstrate the attachment of fluorophores and up to 3000 molecules of 2 kDa poly(ethylene glycol) (PEG2k) to each of the phage capsids without significantly affecting the binding of phage-displayed antibody fragments to EGFR and HER2 (two important epidermal growth factor receptors). We also demonstrate the utility of the modified phage for the characterization of breast cancer cells using multicolor fluorescence microscopy. Due to the widespread use of filamentous phage as display platforms for peptide and protein evolution, we envision that the ability to attach large numbers of synthetic functional groups to their coat proteins will be of significant value to the biological and materials communities.