gebhart/patrepeval huggingface dataset:
Freeform and Thin-Film Optics for a 45% Conversion Efficiency Photovoltaic Concentrator (2016)

Freeform surfaces are important in designing state-of-the-art nonimaging optics for high efficiency concentration phototovoltaics (CPV). CPV designs will be presented that use freeform and thin-film optical components with the potential to achieve 45% electrical conversion.
Re: PC3 is a Cell Line Characteristic of Prostatic Small Cell Carcinoma (2012)

No AccessJournal of UrologyInvestigative Urology1 Jul 2012Re: PC3 is a Cell Line Characteristic of Prostatic Small Cell Carcinoma Anthony AtalaM.D. Anthony AtalaAnthony Atala View All Author Informationhttps://doi.org/10.1016/j.juro.2012.03.074AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: PC3 is a Cell Line Characteristic of Prostatic Small Cell Carcinoma." The Journal of Urology, 188(1), p. 325 © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 188 Issue 1 July 2012 Page: 325 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.Metrics Author Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Towards a Healthy Human Model of Neural Disorders of Movement (2012)

A quantitative approach to virtual-lesion physiology is presented which integrates event-related fMRI, image-guided, repetitive, transcranial magnetic stimulation (irTMS), and simultaneous recording of 3-D movement kinematics. By linking motor neuroscience with clinical disorders of motor function, our method allows development of a healthy, human system model of disorders of skilled action.
Regiospecific N-alkyl substitution tunes the molecular packing of high-performance non-fullerene acceptors (2021)

The rapid development of non-fullerene acceptors (NFAs) with strong near-infrared absorption has led to remarkably enhanced short-circuit current density (<i>J</i><sub>sc</sub>) values in organic solar cells (OSCs). NFAs based on the benzotriazole (Bz) fused-ring π-core have great potential in delivering both high <i>J</i><sub>sc</sub> and decent open-circuit voltage values due to their strong intramolecular charge transfer with reasonably low energy loss. In this work, we have designed and synthesized a series of Bz-based NFAs, PN6SBO-4F, AN6SBO-4F and EHN6SEH-4F, <i>via</i> regiospecific <i>N</i>-alkyl engineering based on the high-performance NFA mBzS-4F that was reported previously. The molecular packing of mBzS-4F, AN6SBO-4F, and EHN6SEH-4F single crystals was analyzed using X-ray crystallography in order to provide a comprehensive understanding of the correlation between the molecular structure, the charge-transporting properties, and the solar cell performance. Compared with the typical honeycomb single-crystal structure of Y6 derivatives, these NFAs exhibit distinctly different molecular packing patterns. The strong interactions of terminal indanone groups in mBzS-4F and the <i>J</i>-aggregate-like packing in EHN6SEH-4F lead to the formation of ordered 3D networks in single-crystals with channels for efficient charge transport. Consequently, OSCs based on mBzS-4F and EHN6SEH-4F show efficient photon-to-current conversions, achieving the highest power conversion efficiency of 17.48% with a <i>J</i><sub>sc</sub> of 28.83 mA cm<sup>-2</sup>.
INCORPORACIÓN DE APLICACIONES Y PRÁCTICAS DE COMERCIO ELECTRÓNICO EN MICRO Y PEQUEÑAS EMPRESAS PROVEEDORAS DE LA ZONA NORTE QUE OPERAN EN EL CLUSTER MINERO. (2011)

Incorporar a 500 proveedores Micro y Pequenos de la Zona Norte que prestan servicios o venden bienes a la gran mineria al Comercio Electronico Business to Business (B2B).
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms (2016)

ABSTRACT Genetic variants affecting hematopoiesis can influence commonly measured blood cell traits. To identify factors that affect hematopoiesis, we performed association studies for blood cell traits in the population-based Estonian Biobank using high coverage whole genome sequencing (WGS) in 2,284 samples and SNP genotyping in an additional ~17,000 samples. Our analyses identified 17 associations across 14 blood cell traits. Integration of WGS-based fine-mapping and complementary epigenomic data sets provided evidence for causal mechanisms at several loci, including at a novel basophil count-associated locus near the master hematopoietic transcription factor CEBPA. The fine-mapped variant at this basophil count association near CEBPA overlapped an enhancer active in common myeloid progenitors and influenced its activity. In situ perturbation of this enhancer by CRISPR/Cas9 mutagenesis in hematopoietic stem and progenitor cells demonstrated that it is necessary for and specifically regulates CEBPA expression during basophil differentiation. We additionally identified basophil count-associated variation at another more pleiotropic myeloid enhancer near GATA2 , highlighting regulatory mechanisms for ordered expression of master hematopoietic regulators during lineage specification. Our study illustrates how population-based genetic studies can provide key insights into poorly understood cell differentiation processes of considerable physiologic relevance.
Optimizing COVID-19 control with asymptomatic surveillance testing in a university environment (2020)

The high proportion of transmission events derived from asymptomatic or presymptomatic infections make SARS-CoV-2, the causative agent in COVID-19, difficult to control through the traditional non-pharmaceutical interventions (NPIs) of symptom-based isolation and contact tracing. As a consequence, many US universities developed asymptomatic surveillance testing labs, to augment NPIs and control outbreaks on campus throughout the 2020-2021 academic year (AY); several of those labs continue to support asymptomatic surveillance efforts on campus in AY2021-2022. At the height of the pandemic, we built a stochastic branching process model of COVID-19 dynamics at UC Berkeley to advise optimal control strategies in a university environment. Our model combines behavioral interventions in the form of group size limits to deter superspreading, symptom-based isolation, and contact tracing, with asymptomatic surveillance testing. We found that behavioral interventions offer a cost-effective means of epidemic control: group size limits of six or fewer greatly reduce superspreading, and rapid isolation of symptomatic infections can halt rising epidemics, depending on the frequency of asymptomatic transmission in the population. Surveillance testing can overcome uncertainty surrounding asymptomatic infections, with the most effective approaches prioritizing frequent testing with rapid turnaround time to isolation over test sensitivity. Importantly, contact tracing amplifies population-level impacts of all infection isolations, making even delayed interventions effective. Combination of behavior-based NPIs and asymptomatic surveillance also reduces variation in daily case counts to produce more predictable epidemics. Furthermore, targeted, intensive testing of a minority of high transmission risk individuals can effectively control the COVID-19 epidemic for the surrounding population. Even in some highly vaccinated university settings in AY2021-2022, asymptomatic surveillance testing offers an effective means of identifying breakthrough infections, halting onward transmission, and reducing total caseload. We offer this blueprint and easy-to-implement modeling tool to other academic or professional communities navigating optimal return-to-work strategies.
Effect of nitrogen incorporation on improvement of leakage properties in high-k HfO2 capacitors treated by N2-plasma (2005)

The nitrogen incorporation into the HfO2 films with an EOT (equivalent oxide thickness) of 9Å was performed by N2-plasma to improve the electrical properties. The dielectric properties and a leakage current characteristics of the capacitors were investigated as a function of plasma power and plasma treatment temperature. The dielectric constant of the capacitors is not influenced by nitrogen incorporation. The N2-plasma treatment at 300°C and 70W exhibits the most effective influence on improvement of the leakage current characteristics. Leakage current density of the capacitors treated at 300°C and 70W exhibits a half order of magnitude lower than that without plasma treatment. Nitrogen incorporated into the HfO2 films possesses the intrinsic effect that drastically reduce the electron leakage current through HfO2 dielectrics by deactivating the VO (oxygen vacancy) related gap states.
Alternating Oligo(p-phenylene vinylene)−Perylene Bisimide Copolymers:  Synthesis, Photophysics, and Photovoltaic Properties of a New Class of Donor−Acceptor Materials (2003)

A Suzuki polycondensation reaction has been used to synthesize two copolymers consisting of alternating oligo(p-phenylene vinylene) (OPV) donor and perylene bisimide (PERY) acceptor chromophores. The copolymers differ by the length of the saturated spacer that connects the OPV and PERY units. Photoinduced singlet energy transfer and photoinduced charge separation in these polychromophores have been studied in solution and in the solid state via photoluminescence and femtosecond pump-probe spectroscopy. In both polymers a photoinduced electron transfer occurs within a few picoseconds after excitation of the OPV or the PERY chromophore. The electron transfer from OPV excited state competes with a singlet energy transfer state to the PERY chromophore. The differences in rate constants for the electron- and energy-transfer processes are discussed on the basis of correlated quantum-chemical calculations and in terms of conformational preferences and folding of the two polymers. In solution, the lifetime of the charge-separated state is longer than in the films where geminate recombination is much faster. However, in the films some charges are able to escape from geminate recombination and diffuse away and can be collected at the electrodes when the polymers are incorporated in a photovoltaic device.
DNA-Encoded Protein Janus Nanoparticles* (2020)

Asymmetric functionality and directional interactions, which are characteristic of noncentrosymmetric particles, such as Janus particles, present an opportunity to encode particles with properties, but also a great synthetic challenge. This chapter exploits the chemical anisotropy of proteins, and the versatile chemistry of DNA to synthesize a protein-based Janus nanoparticle comprised of two proteins encoded with sequence-specific nucleic acid domains, tethered together by an interprotein “DNA bond.” It utilizes these novel nanoparticles to realize a new class of three-dimensional superlattice, only possible when two sides of the particle are modified with orthogonal oligonucleotide sequences. DNA is a highly programmable surface ligand because its sequence, length, and thus interaction strength can all be deliberately modulated to impart surfaces with specific binding properties. A powerful aspect of using Janus particles in DNA-mediated crystallization is the ability to coassemble with two sets of differently functionalized nanoparticles.
Formation of Thiazole and 1,3-Thiazolidine Sulfoxide from Pyrolysis of a Thiolsulfinate (1997)

The mechanistic study on the pyrolytic transformation of a thiolsulfinate (2) is described.The reactive intermediates sulfenic acid (6) and thioaldehyde (8) were formed resulting from S-S bond cleavage and a hydrogen transfer from sulfenyl to sulfinyl moiety.A stereospecific cyclization of 6 to cissulfoxide (4) was observed, which arouse from the geometrical requirements of a planar transition state for the reacting bonds and atoms in the sigmatropic rearrangement.In the transformation of 8 to thiazole (9), the amide carbonyl group facilitated the elimination of a neighboring proton and enabled to furnish the nucleophilic attack of a thiocarbonyl sulfur at to internal carbonyl group to yield thiazole (9).
Novel pentacoordinate anionic silicate, [o-C6H4(SiPhF2)2F]-K+.cntdot.18-crown-6, containing a bent fluoride bridge between two silicon atoms [Erratum to document cited in CA112(15):139129y] (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel pentacoordinate anionic silicate, [o-C6H4(SiPhF2)2F]-K+.cntdot.18-crown-6, containing a bent fluoride bridge between two silicon atoms [Erratum to document cited in CA112(15):139129y]Kohei Tamao, Takashi Hayashi, Yoshihiko Ito, and Motoo ShiroCite this: J. Am. Chem. Soc. 1990, 112, 14, 5679Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://doi.org/10.1021/ja00170a065RIGHTS & PERMISSIONSArticle Views49Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (122 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Reduction of retinal ganglion cell death in mouse models of familial dysautonomia using AAV-mediated gene therapy and splicing modulators (2023)

Familial dysautonomia (FD) is a rare neurodevelopmental and neurodegenerative disease caused by a splicing mutation in the Elongator Acetyltransferase Complex Subunit 1 ( <i>ELP1</i> ) gene. The reduction in ELP1 mRNA and protein leads to the death of retinal ganglion cells (RGCs) and visual impairment in all FD patients. Currently, patient symptoms are managed, but there is no treatment for the disease. We sought to test the hypothesis that restoring levels of Elp1 would thwart the death of RGCs in FD. To this end, we tested the effectiveness of two therapeutic strategies for rescuing RGCs. Here we provide proof-of-concept data that gene replacement therapy and small molecule splicing modifiers effectively reduce the death of RGCs in mouse models for FD and provide pre-clinical data foundation for translation to FD patients.
Analysis of variants in the complement factor H, the elongation of very long chain fatty acids-like 4 and the hemicentin 1 genes of age-related macular degeneration in the Finnish population. (2006)

The CFH gene polymorphism seems to be an important etiologic factor for AMD also in the isolated Finnish population.
Modification of Decoy Oligodeoxynucleotides to Achieve the Stability and Therapeutic Efficacy (2012)

The decoy oligodeoxynucleotide (ODN) serves as a decoy sequence for a target transcription factor, then inhibiting its binding to the authentic sequence at the promoter, and consequently hinders the gene expression. ODNs should be properly up taken by the cell and tissue, be specific for one nuclear factor, and be stable against intracellular and serum nucleases. Since phosphodiester oligos are easily degradated by nucleases, chemical modification such as phosphorothioation, and structural modification by ligation of the extremities of two single-strand phosphodiester sequence resulting in a dumbbell shaped ODN (Ribbon-type decoy ODN) are performed to increase the stability of ODNs. In combination, phosphorothioation of specific regions in Ribbon-type decoy has further increased its stability, and the introduction of saturated hydrocarbon polymer spacer linking the two double strands also improved the stability and reduced the production cost. The cellular delivery has been optimized by using the biodegradable polymer D,L-lactide-co-glycolide (PLGA) as a carrier to ODN. The nuclear factor-kappa B (NF-κB) is a convergent point of different pathways, with main role in many pathologies, and poses as an ideal target for decoy ODN strategy. Following this we have designed ODN targeting NF-κB, and in this review, we are going to discuss the various modification performed in an attempt to improve the ODN efficacy, and some promising pre-clinical data and clinical trials using NF-κB decoy ODN.
Surface extended x-ray absorption fine structure of underpotentially deposited silver on gold(111) electrodes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface extended x-ray absorption fine structure of underpotentially deposited silver on gold(111) electrodesJ. H. White, M. J. Albarelli, H. D. Abruna, L. Blum, O. R. Melroy, M. G. Samant, G. L. Borges, and J. G. Gordon IICite this: J. Phys. Chem. 1988, 92, 15, 4432–4436Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/j100326a037https://doi.org/10.1021/j100326a037research-articleACS PublicationsRequest reuse permissionsArticle Views125Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Simultaneous scanning ion conductance and atomic force microscopy with a nanopore: Effect of the aperture edge on the ion current images (2018)

Scanning ion conductance microscopy (SICM) is a technique for high-resolution non-contact imaging, particularly powerful for live cell studies. Despite debates on its lateral resolution, consensus is that a probe presenting a tip with small opening aperture, large opening angle, and large outer-to-inner radius ratio will offer a SICM current signal more sensitive to tip-sample separation, ultimately impacting the image resolution. We report here the design of such a probe, integrating a nano-opening (&amp;lt;20 nm opening diameter) with increased outer-to-inner radius ratio and a wide opening angle through microfabrication and ion milling. The probe consists of a microfluidic atomic force microscopy (AFM) cantilever offered by the Fluid Force Microscope (FluidFM) technology, able to act as an SICM and AFM probe. Such a combination allows investigating the implications of the new probe geometry on the SICM imaging process by simultaneously recording currents and forces. We demonstrate through experiments on well-defined samples as well as corresponding simulations that by integrating a nanopore onto the FluidFM, nanoscale features could be successfully imaged, but the increased sensitivity of the probe current to sample distance comes with higher sensitivity to an inherent SICM wall artefact.
Carrier-Grade Voice over LTE: Advantages and Challenges (2014)

Data usage is surging in wireless networks and operators are quickly moving from second generation/third generation (2G/3G) networks towards 3rd Generation Partnership Project (3GPP) Long Term Evolution (LTE) which is expected to provide significant data capacity and latency improvements. In this paper, we examine the benefits of a complete transition from mixed 2G/3G/LTE networks to an all- LTE network with the ability to provide unified voice and data services. These benefits are explored from both a network operator and equipment vendor point of view. Carrier-grade voice over LTE is expected to be an important requirement for this transition and some initial deployment configurations may present challenges in terms of coverage and capacity; in this paper we explore these challenges and ways to overcome them.
ChemInform Abstract: A New and Practical Approach to the Synthesis of Taxol and Taxol Analogues: The Pinene Path. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Water-Mediated Catalyst Preactivation for Efficient Pd-Catalyzed Aminations (2008)

A new efficient protocol for Pd-catalyzed amination reactions is described in this article. Preactivation of the Pd(OAc)2-biaryldialkyl­phosphine catalyst system with water leads to shorter reaction times, avoids the use of additives, such as BEt3, and allows lower catalyst loadings in couplings of amides and anilines with aryl chlorides.
Co-Registration of pre- and post-Operative images after cochlear Implantation: A proposed technique to Improve cochlear visualization and localization of cochlear electrodes (2022)

Following cochlear implantation, co-registered pre- and post-operative CT images are superior to conventional images in assessing the anatomic relationship between the cochlea and FNC.
Monomeric and Polymeric N-Halamine Disinfectants (1998)

A new series of N-halamine compounds have been synthesized and tested in aqueous solution and on various substrates for efficacy at inactivating bacteria. The compounds, which are 3-halo-4-[[(alkylacryl)oxy]methyl]-4-ethyl-2-oxazolidinones, are inexpensive to synthesize and can be polymerized to form polymeric N-halamine compounds. They are efficient biocides in their monomeric form in aqueous solution, and when polymerized, they can be coated on glass, plastic, and fibrous materials for use as surface-active disinfection agents.