gebhart/patrepeval huggingface dataset:
Efficiency-limiting processes in Ga(NAsP)/GaP quantum well lasers (2012)

We report on the carrier recombination mechanisms in dilute nitride Ga(NAsP)/GaP quantum well lasers. Spontaneous emission measurements show that defect-related recombination in the devices is less significant compared with other GaAs-based dilute nitride lasers. From temperature dependent measurements, we find that the threshold current density, Jth is dominated by non-radiative recombination process(es), which account for at least 91% of Jth at room temperature. The characteristic temperature, T0 (T1) is measured to be ∼104 K (∼99 K) around 200 K, which drops to ∼58 K ( ∼37 K) around room temperature. Hydrostatic pressure measurements reveal a strong increase of threshold current with increasing pressure. This implies that current leakage dominates carrier recombination which is also responsible for their low T0 and T1 values at room temperature.
Effects of liquid crystals on diffractive coupling in a diode laser external cavity (1990)

A seven-element gain-guided AlGaAs diode laser array is used to establish an external cavity which relies on weak diffractive coupling for its operation. Collimation of the lasers is achieved using a binary-optics microlens array. A nematic liquid crystal phase modulator is placed in the image plane of the lenslet array to provide individual phase control of each laser stripe. It is shown that the liquid crystal phase modulator is capable of establishing partial coherence by independent adjustment of the laser optical path lengths.
Duplex and Quadruplex DNA Binding and Photocleavage by Trioxatriangulenium Ion (2005)

The stable trioxatriangulenium ion (TOTA) has previously been shown to bind to and photooxidize duplex DNA, leading to cleavage at G residues, particularly 5'-GG-3' repeats. Telomeric DNA consists of G-rich sequences that may exist in either duplex or G-quadruplex forms. We have employed electrospray ionization mass spectrometry (ESI-MS) to investigate the interactions between TOTA and duplex DNA or G-quadruplex DNA. A variety of duplex decamer oligodeoxynucleotides form complexes with TOTA that can be detected by ESI-MS, and the stoichiometry and fragmentation patterns observed are commensurate with an intercalative binding mode. TOTA also forms complexes with four-stranded and hairpin-dimer G-quadruplex oligodeoxynucleotides that can be detected by ESI-MS. Both the stoichiometry and the fragmentation patterns observed by ESI-MS are different than those observed for G-tetrad end-stacking binding ligands. We have carried out (1)H NMR titrations of a four-stranded G-quadruplex in the presence of TOTA. Addition of up to 1 equiv of TOTA is accompanied by pronounced upfield shifts of the G-tetrad imino proton resonances in the NMR, which is similar to the effect observed for G-tetrad end-stacking ligands. At higher ratios of added TOTA, there is evidence for additional binding modes. Duplex DNA containing either human telomeric repeats (T(2)AG(3))(4) or the Tetrahymena telomeric repeats (T(2)G(4))(4) are readily photooxidized by TOTA, the major sites of oxidation being the central guanine residues in each telomeric repeat. These telomeric repeats were incorporated into duplex/quadruplex chimeras in which the repeats adopt a G-quadruplex structure. Analysis by denaturing polyacrylamide gel electrophoresis reveals significantly less TOTA photocleavage of these quadruplex telomeric repeats when compared to the duplex repeats.
Performance of Transmit Time Selection Diversity in Multipath Fading Channels (2003)

We examine transmit time selection diversity (TTSD) concept, where downlink transmission is suspended if the received SNR in the mobile station falls below a given threshold. In case of FDD systems, this requires a fast feedback channel from mobile to base like the one in the FDD WCDMA system. Bit error probability formulas are derived showing that TTSD is able to provide gains up to several decibels when compared to continuous transmission. Results also indicate that if the wireless environment already provides diversity --- as in the case of multipath fading channels and transmit diversity --- gains against continuous transmission are smaller.
Notice of Removal: Volumetric ultrafast ultrasound localization microscopy using a 32×32 matrix array (2017)

Removed.
A phenotypically and functionally distinct human T H 2 cell subpopulation is associated with allergic disorders (2017)

Allergen-specific type 2 helper T (T<sub>H</sub>2) cells play a central role in initiating and orchestrating the allergic and asthmatic inflammatory response pathways. One major factor limiting the use of such atopic disease-causing T cells as both therapeutic targets and clinically useful biomarkers is the lack of an accepted methodology to identify and differentiate these cells from overall nonpathogenic T<sub>H</sub>2 cell types. We have described a subset of human memory T<sub>H</sub>2 cells confined to atopic individuals that includes all allergen-specific T<sub>H</sub>2 cells. These cells are terminally differentiated CD4<sup>+</sup> T cells (CD27<sup>-</sup> and CD45RB<sup>-</sup>) characterized by coexpression of CRT<sub>H</sub>2, CD49d, and CD161 and exhibit numerous functional attributes distinct from conventional T<sub>H</sub>2 cells. Hence, we have denoted these cells with this stable allergic disease-related phenotype as the T<sub>H</sub>2A cell subset. Transcriptome analysis further revealed a distinct pathway in the initiation of pathogenic responses to allergen, and elimination of these cells is indicative of clinical responses induced by immunotherapy. Together, these findings identify a human T<sub>H</sub>2 cell signature in allergic diseases that could be used for response-monitoring and designing appropriate immunomodulatory strategies.
Evidence for the Strangeness-Changing Weak DecayΞb−→Λb0π− (2015)

Using a pp collision data sample corresponding to an integrated luminosity of 3.0 fb^{-1}, collected by the LHCb detector, we present the first search for the strangeness-changing weak decay Ξ_{b}^{-}→Λ_{b}^{0}π^{-}. No b hadron decay of this type has been seen before. A signal for this decay, corresponding to a significance of 3.2 standard deviations, is reported. The relative rate is measured to be f_{Ξ_{b}^{-}}/f_{Λ_{b}^{0}}B(Ξ_{b}^{-}→Λ_{b}^{0}π^{-})=(5.7±1.8_{-0.9}^{+0.8})×10^{-4},where f_{Ξ_{b}^{-}} and f_{Λ_{b}^{0}} are the b→Ξ_{b}^{-} and b→Λ_{b}^{0} fragmentation fractions, and B(Ξ_{b}^{-}→Λ_{b}^{0}π^{-}) is the branching fraction. Assuming f_{Ξ_{b}^{-}}/f_{Λ_{b}^{0}} is bounded between 0.1 and 0.3, the branching fraction B(Ξ_{b}^{-}→Λ_{b}^{0}π^{-}) would lie in the range from (0.57±0.21)% to (0.19±0.07)%.
Data from Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Mutant KRAS is a major driver of pancreatic oncogenesis and therapy resistance, yet KRAS inhibitors are lacking in the clinic. KRAS requires farnesylation for membrane localization and cancer-causing activity prompting the development of farnesyltransferase inhibitors (FTIs) as anticancer agents. However, KRAS becomes geranylgeranylated and active when cancer cells are treated with FTIs. To overcome this geranylgeranylation-dependent resistance to FTIs, we designed FGTI-2734, a RAS C-terminal mimetic dual FT and geranylgeranyltransferase-1 inhibitor (GGTI).&lt;/p&gt;Experimental Design:&lt;p&gt;Immunofluorescence, cellular fractionation, and gel shift assays were used to assess RAS membrane association, Western blotting to evaluate FGTI-2734 effects on signaling, and mouse models to demonstrate its antitumor activity.&lt;/p&gt;Results:&lt;p&gt;FGTI-2734, but not the selective FTI-2148 and GGTI-2418, inhibited membrane localization of KRAS in pancreatic, lung, and colon human cancer cells. FGTI-2734 induced apoptosis and inhibited the growth in mice of mutant KRAS–dependent but not mutant KRAS–independent human tumors. Importantly, FGTI-2734 inhibited the growth of xenografts derived from four patients with pancreatic cancer with mutant KRAS (2 G12D and 2 G12V) tumors. FGTI-2734 was also highly effective at inhibiting, in three-dimensional cocultures with resistance promoting pancreatic stellate cells, the viability of primary and metastatic mutant KRAS tumor cells derived from eight patients with pancreatic cancer. Finally, FGTI-2734 suppressed oncogenic pathways mediated by AKT, mTOR, and cMYC while upregulating p53 and inducing apoptosis in patient-derived xenografts &lt;i&gt;in vivo&lt;/i&gt;.&lt;/p&gt;Conclusions:&lt;p&gt;The development of this novel dual FGTI overcomes a major hurdle in KRAS resistance, thwarting growth of patient-derived mutant KRAS–driven xenografts from patients with pancreatic cancer, and as such it warrants further preclinical and clinical studies.&lt;/p&gt;&lt;/div&gt;
Supplementary Table 3 from Epigenetically Deregulated microRNA-375 Is Involved in a Positive Feedback Loop with Estrogen Receptor α in Breast Cancer Cells (2023)

Supplementary Table 3 from Epigenetically Deregulated microRNA-375 Is Involved in a Positive Feedback Loop with Estrogen Receptor α in Breast Cancer Cells
ChemInform Abstract: New Bis‐Lactam Chiral Auxiliaries for Nitrile Oxide Cycloadditions. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Two-Photon “Caging” Groups: Effect of Position Isomery on the Photorelease Properties of Aminoquinoline-Derived Photolabile Protecting Groups (2015)

High two-photon photolysis cross sections and water solubility of probes are important to avoid toxicity in biomedical applications of photolysis. Systematic variation of the position of a carboxyl electron-withdrawing group (EWG) on photolysis of 8-dimethylaminoquinoline protecting groups identified the C5-substituted isomer as a privileged dipole. The 5-benzoyl-8-DMAQ substitution yields a caging group with an enhanced two-photon uncaging cross section (δu = 2.0 GM) and good water solubility (c ≤ 50 mM, pH 7.4).
Design, Modeling, and Fabrication of Chemical Vapor Deposition Grown MoS2 Circuits with E-Mode FETs for Large-Area Electronics (2016)

Two-dimensional electronics based on single-layer (SL) MoS<sub>2</sub> offers significant advantages for realizing large-scale flexible systems owing to its ultrathin nature, good transport properties, and stable crystalline structure. In this work, we utilize a gate first process technology for the fabrication of highly uniform enhancement mode FETs with large mobility and excellent subthreshold swing. To enable large-scale MoS<sub>2</sub> circuit, we also develop Verilog-A compact models that accurately predict the performance of the fabricated MoS<sub>2</sub> FETs as well as a parametrized layout cell for the FET to facilitate the design and layout process using computer-aided design (CAD) tools. Using this CAD flow, we designed combinational logic gates and sequential circuits (AND, OR, NAND, NOR, XNOR, latch, edge-triggered register) as well as switched capacitor dc-dc converter, which were then fabricated using the proposed flow showing excellent performance. The fabricated integrated circuits constitute the basis of a standard cell digital library that is crucial for electronic circuit design using hardware description languages. The proposed design flow provides a platform for the co-optimization of the device fabrication technology and circuits design for future ubiquitous flexible and transparent electronics using two-dimensional materials.
P‐46: Optimization of Subpixel Color Tiles for Mobile Displays (2008)

Abstract A key issue for the optimization of subpixel color tiles for mobile displays is to maximize the image quality, often defined in terms of brightness or reflectance, and color saturation, while minimizing display power consumption. for the mirasol™ display based on MEMS technology, the RGBY quad is found to be a structure that achieves a balance between reflectance and color saturation. Simulation results based upon demonstration devices are presented with discussions about proper image quality metrics for mobile displays.
Search for anomalous Wtb couplings and flavour-changing neutral currents in t-channel single top quark production in pp collisions at s = 7 $$ \sqrt{s}=7 $$ and 8 TeV (2017)

Single top quark events produced in the t channel are used to set limits on anomalous Wtb couplings and to search for top quark flavour-changing neutral current (FCNC) interactions. The data taken with the CMS detector at the LHC in proton-proton collisions at s = 7 and 8 TeV correspond to integrated luminosities of 5.0 and 19.7 fb -1 , respectively. The analysis is performed using events with one muon and two or three jets. A Bayesian neural network technique is used to discriminate between the signal and backgrounds, which are observed to be consistent with the standard model prediction. The 95% confidence level (CL) exclusion limits on anomalous right-handed vector, and left-and righthanded tensor Wtb couplings are measured to be |f R V | < 0.16, |f L T | < 0.057, and -0.049 < f R T < 0.048, respectively. For the FCNC couplings tug and tcg , the 95% CL upper limits on coupling strengths are | tug |/ < 4.1 10 -3 TeV -1 and | tcg |/ < 1.8 10 -2 TeV -1 , where is the scale for new physics, and correspond to upper limits on the branching fractions of 2.0 10 -5 and 4.1 10 -4 for the decays t ug and t cg, respectively.
Evaluation of silica nanoparticle binding to major human blood proteins (2014)

Nanomaterials are used for various biomedical applications because they are often more effective than conventional materials. Recently, however, it has become clear that the protein corona that forms on the surface of nanomaterials when they make contact with biological fluids, such as blood, influences the pharmacokinetics and biological responses induced by the nanomaterials. Therefore, when evaluating nanomaterial safety and efficacy, it is important to analyze the interaction between nanomaterials and proteins in biological fluids and to evaluate the effects of the protein corona. Here, we evaluated the interaction of silica nanoparticles, a commonly used nanomaterial, with the human blood proteins albumin, transferrin, fibrinogen, and IgG. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis showed that the amount of albumin, transferrin, and IgG binding to the silica particles increased as the particle size decreased under conditions where the silica particle mass remained the same. However, under conditions in which the specific surface area remained constant, there were no differences in the binding of human plasma proteins to the silica particles tested, suggesting that the binding of silica particles with human plasma proteins is dependent on the specific surface area of the silica particles. Furthermore, the amount of albumin, transferrin, and IgG binding to silica nanoparticles with a diameter of 70 nm (nSP70) and a functional amino group was lower than that with unmodified nSP70, although there was no difference in the binding between nSP70 with the surface modification of a carboxyl functional group and nSP70. These results suggest that the characteristics of nanomaterials are important for binding with human blood proteins; this information may contribute to the development of safe and effective nanomaterials.
Fidelius: Protecting User Secrets from Compromised Browsers (2019)

Users regularly enter sensitive data, such as passwords, credit card numbers, or tax information, into the browser window. While modern browsers provide powerful client-side privacy measures to protect this data, none of these defenses prevent a browser compromised by malware from stealing it. In this work, we present Fidelius, a new architecture that uses trusted hardware enclaves integrated into the browser to enable protection of user secrets during web browsing sessions, even if the entire underlying browser and OS are fully controlled by a malicious attacker. Fidelius solves many challenges involved in providing protection for browsers in a fully malicious environment, offering support for integrity and privacy for form data, JavaScript execution, XMLHttpRequests, and protected web storage, while minimizing the TCB. Moreover, interactions between the enclave and the browser, the keyboard, and the display all require new protocols, each with their own security considerations. Finally, Fidelius takes into account UI considerations to ensure a consistent and simple interface for both developers and users. As part of this project, we develop the first open source system that provides a trusted path from input and output peripherals to a hardware enclave with no reliance on additional hypervisor security assumptions. These components may be of independent interest and useful to future projects. We implement and evaluate Fidelius to measure its performance overhead, finding that Fidelius imposes acceptable overhead on page load and user interaction for secured pages and has no impact on pages and page components that do not use its enhanced security features.
Identification of Novel Biomarkers for Niemann–Pick Disease Using Gene Expression Analysis of Acid Sphingomyelinase Knockout Mice (2005)

Although several therapies are available or being developed for lysosomal storage disorders (LSDs), assessment of therapeutic efficacy is challenged by the lack of markers to assess disease progression and severity. This is particularly true for rare diseases such as LSDs, since natural history data from human populations are often lacking. Herein we describe the use of gene expression analysis in the acid sphingomyelinase-deficient mouse model (ASMKO) of Types A and B Niemann-Pick disease (NPD) to identify novel serum biomarkers. We used microarray and real-time PCR analyses to compare mRNA expression in ASMKO and normal mice in two important sites of pathology, lung and brain, and from these data identified and validated several potential biomarkers. The cytokine MIP-1alpha was markedly elevated in ASMKO mouse serum, and following enzyme replacement therapy (ERT) it was reduced to normal levels. Total iron levels were similarly elevated in ASMKO mice, reflective of the elevated ferritin light chain transcript, and decreased to normal after ERT. Serum growth hormone levels were also elevated in ASMKO mice and were reduced to normal after brain-directed gene therapy, but not ERT. These studies illustrate the value of gene expression analysis for the identification of biomarkers, and provide new insight into the pathobiology of NPD.
Adhesion Behavior of Chondrocyte and Osteoblast on Surface-Modified Biodegradable PLLA Films and Scaffolds (2012)

Poly(L-lactic acid)(PLLA) 고분자 필름 및 지지체의 세포 친화성을 향상시키기 위하여 산소 플라즈마 처리후 카복실기를 함유한 아크릴산(AA)을 <TEX>$in$</TEX> <TEX>$situ$</TEX> 그래프트시켰다. Stimulated body fluid(SBF) 용액에 15일간 담지시킨 후 hydroxyapatite(HA)를 형성시킨 시료와 phosphate-buffered saline(PBS), fetal bovine serum(FBS), 식염수 및 세포 배양용 배지에 담지시킨 다음 PLLA 시료 표면의 접촉각을 비교해 본 결과, HA 표면이 가장 낮은 접촉각을 나타내었다. 또한 연골세포와 조골세포는 HA 표면 위에서 높은 점착과 성장을 보였으며 연골세포가 HA에 많은 영향을 받는 것으로 확인되었다. 조골세포의 경우 HA 표면 이외에도 FBS나 세포 배양배지에 담지된 표면에서도 높은 세포 증식을 보였다. 더욱이 필름형태보다는 3차원 입체 구조의 다공성 지지체에서 연골세포와 조골세포의 점착과 세포 증식이 향상됨도 확인할 수 있었다. 이러한 표면개질된 PLLA는 조직공학적으로 연골이나 뼈 재생을 위한 유-무기 하이브리드 지지체로 응용될 수 있을 것으로 기대된다. Surface-modified poly(L-lactic acid) (PLLA) films and scaffolds were treated with plasma discharge in oxygen gas and subsequently subjected to <TEX>$in$</TEX> <TEX>$situ$</TEX> grafting of acrylic acid (AA) in order to increase the cell compatibility. The surface of AA-grafted PLLA was converted to hydroxyapatite (HA)-deposited PLLA in stimulated body fluid (SBF). After the samples were immersed in phosphate-buffered saline (PBS), fetal bovine serum (FBS), normal saline, or cell medium, the water contact angles were significantly reduced on the surface of HA-deposited PLLA. Chondrocyte and osteoblast showed a higher attachment and cell proliferation on HA-deposited surfaces and in particular, it was confirmed that chondrocyte was considerably influenced by HA. However, osteoblast showed better cell proliferation on the surfaces immersed in FBS, cell medium or HA-deposited surface. In addition, the cell proliferation in 3D scaffolds was much higher than that on film type, irrespective of chondrocyte and osteoblast. Therefore, such surface-modified PLLAs are expected to be useful as organic-inorganic hybrid scaffolds in the regeneration of cartilage and bone.
Supplementary Data from Preclinical Assessment of a MUC12-Targeted BiTE (Bispecific T-cell Engager) Molecule (2023)

&lt;p&gt;Includes supplemental methods, tables and figures.&lt;/p&gt;
High frequency performance characterization of super-fine inkjet printed silver traces (2016)

In this paper, the adhesion and high frequency performance of super-inkjet printed traces are investigated on a laminate (RO3006) typically used for high frequency applications. The results are compared with glass as reference substrates. The results show improved adhesion on RO3006 due to the presence of surface roughness. However the insertion loss is also higher due to the skin effect arising from the substrate surface roughness. Future plans include optimizing the substrate surface roughness to develop super-fine inkjet printed silver traces on fabric.
Mechanism‐Based Development of Memantine as a Therapeutic Agent in Treating Alzheimer's Disease and Other Neurologic Disorders: Low‐Affinity, Uncompetitive Antagonism with Fast Off‐Rate (2006)

This chapter contains sections titled: Introduction Excitotoxicity Rational Drug Design of Clinically Tolerated NMDA Receptor Antagonists Memantine Nitromemantines Conclusions Acknowledgments References
With Great Dispersion Comes Greater Resilience: Efficient Poisoning Attacks and Defenses for Linear Regression Models (2021)

With the rise of third parties in the machine learning pipeline, the service provider in “Machine Learning as a Service” (MLaaS), or external data contributors in online learning, or the retraining of existing models, the need to ensure the security of the resulting machine learning models has become an increasingly important topic. The security community has demonstrated that without transparency of the data and the resulting model, there exist many potential security risks, with new risks constantly being discovered. In this paper, we focus on one of these security risks - poisoning attacks. Specifically, we analyze how attackers may interfere with the results of regression learning by poisoning the training datasets. To this end, we analyze and develop a new poisoning attack algorithm. Our attack, termed Nopt, in contrast with previous poisoning attack algorithms, can produce larger errors with the same proportion of poisoning data-points. Furthermore, we also significantly improve the state-of-the-art defense algorithm, termed TRIM, proposed by Jagielsk et al. (IEEE S&P 2018), by incorporating the concept of probability estimation of clean data-points into the algorithm. Our new defense algorithm, termed Proda, demonstrates an increased effectiveness in reducing errors arising from the poisoning dataset through optimizing ensemble models. We highlight that the time complexity of TRIM had not been estimated; however, we deduce from their work that TRIM can take exponential time complexity in the worst-case scenario, in excess of Proda's logarithmic time. The performance of both our proposed attack and defense algorithms is extensively evaluated on four real-world datasets of housing prices, loans, health care, and bike sharing services. We hope that our work will inspire future research to develop more robust learning algorithms immune to poisoning attacks.