gebhart/patrepeval huggingface dataset:
Information processing for image sensing under unfavorable photographic conditions (2013)

We investigate the problem of image sensing under unfavorable photographic conditions in a wireless image sensor network. In the scenes with deflective and/or reflective medium such as fogs, mirrors, glasses, degraded images are captured by those image sensors. Such degraded images often lack perceptual vividness and they offer a poor visibility of the scene contents. Notably, computation-intensive method to recover a better image based on single image [2] may not be applicable for wireless image sensors due to the limited computation capacities and the limited power resources (batteries) typically equipped at those wireless image sensors. In this paper, we propose a framework to recover better images under unfavorable photographic conditions in a wireless image sensor network, where a light-weighted computation method based on multiple images is employed to recover better images. Toward the realization of the whole system, we have built image sensor prototypes with commodity cameras and we validated our approach by indepth analysis, extensive simulations and field experiments in real-world situations.
Diabetic retinopathy: Looking forward to 2030 (2023)

Diabetic retinopathy (DR) is the major ocular complication of diabetes mellitus, and is a problem with significant global health impact. Major advances in diagnostics, technology and treatment have already revolutionized how we manage DR in the early part of the 21<sup>st</sup> century. For example, the accessibility of imaging with optical coherence tomography, and the development of anti-vascular endothelial growth factor (VEGF) treatment are just some of the landmark developments that have shaped the DR landscape over the last few decades. Yet, there are still more exciting advances being made. Looking forward to 2030, many of these ongoing developments are likely to further transform the field. First, epidemiologic projections show that the global burden of DR is not only increasing, but also shifting from high-income countries towards middle- and low-income areas. Second, better understanding of disease pathophysiology is placing greater emphasis on retinal neural dysfunction and non-vascular aspects of diabetic retinal disease. Third, a wealth of information is becoming available from newer imaging modalities such as widefield imaging systems and optical coherence tomography angiography. Fourth, artificial intelligence for screening, diagnosis and prognostication of DR will become increasingly accessible and important. Fifth, new pharmacologic agents targeting other non-VEGF-driven pathways, and novel therapeutic strategies such as gene therapy are being developed for DR. Finally, the classification system for diabetic retinal disease will need to be continually updated to keep pace with new developments. In this article, we discuss these major trends in DR that we expect to see in 2030 and beyond.
Associative memory in regenerative spiking micropillar lasers (Conference Presentation) (2020)

Micropillar lasers with integrated saturable absorber (LSA) have been demonstrated to show important neuromimetic properties such as ultrafast excitable behavior, temporal summation, relative & absolute refractory periods and spike latency. In this work we study a LSA with self delayed connection which can show regenerative spiking. Such delayed self connections called as autpases are found in living nervous systems in regions essential for memory. The characteristic response of a single LSA is a 200 ps wide pulse emitted in response to an optical perturbation above the excitable threshold. In the presence of an external feedback, a single above threshold perturbation will trigger a train of pulses. Additional perturbations are capable of retiming an existing pulse train and adding or removing a pulse train, thus enabling all optical control of spikes. If the system is perturbed under correct conditions several times during the external cavity roundtrip time τ, we can create several coexisting pulse trains in the cavity which are essentially the input perturbation repeating with the time period τ. This can be seen as an optical buffer for spikes. However, in the long term these seemingly independent pulses interact and converge towards a stable solution. This final stable solution is based on the input sequence, thus this long term behavior can be seem as an associative memory. Numerical simulations of the Yamada model with delayed feedback and noise are presented and found to be in good agreement with the experimental observations. All the observed dynamics of spike interaction and convergence can be explained solely based with the internal dynamics of carriers.
Family Crucible: The Influence of Family Dynamics in the Life and Ministry of John Wesley (2013)

Book Review| January 01 2013 Family Crucible: The Influence of Family Dynamics in the Life and Ministry of John Wesley Family Crucible: The Influence of Family Dynamics in the Life and Ministry of John WesleyHeadley, Anthony J. Robert Webster Robert Webster Search for other works by this author on: This Site Google Wesley and Methodist Studies (2013) 5: 158–160. https://doi.org/10.2307/42909863 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Robert Webster; Family Crucible: The Influence of Family Dynamics in the Life and Ministry of John Wesley. Wesley and Methodist Studies 1 January 2013; 5 158–160. doi: https://doi.org/10.2307/42909863 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectivePenn State University PressWesley and Methodist Studies Search Advanced Search The text of this article is only available as a PDF. Copyright © 2013 Clements Publishing Group Inc.2013Clements Publishing Group Inc. Article PDF first page preview Close Modal You do not currently have access to this content.
Supplementary Figure 1 from Serologic Markers of Effective Tumor Immunity against Chronic Lymphocytic Leukemia Include Nonmutated B-Cell Antigens (2023)

Supplementary Figure 1 from Serologic Markers of Effective Tumor Immunity against Chronic Lymphocytic Leukemia Include Nonmutated B-Cell Antigens
Optimizing a multi cancer antigen plasmid-based vaccine using an in situ prediction model. (2022)

Abstract Little is known about optimization of a class II restricted plasmid-based vaccine targeting multiple cancer antigens. We set out to define parameters of an in situ prediction model in vaccine design for optimal immunogenicity. Using previously defined immunogenic class II epitopes from five cancer antigens, we evaluated the effects of using linkers between antigens and varying the antigen order. The construct with linkers was superior to the construct without linkers. The mice receiving the vaccine with linkers developed a greater magnitude (p&amp;lt;0.0001), incidence and breadth IFN-g immune response. To determine the optimal antigen order, the sequences of all possible permutations were generated. Each sequence was evaluated in four publicly available algorithms to assess potential generation of immunity and physiochemical properties of the fusion protein. Of all parameters assessed, only predicted class II immunogenicity, in vivo half-life and percent of epitopes in helical secondary structure differed considerably among the constructs. We evaluated three constructs with similarly high class II immunogenicity; one with (A) long in vivo half-life and high percent in helices, one with (B) short half-life and high percent in helices or one with (C) short half-life and low percent in helices. Construct A generated a higher magnitude IFN-g response than Construct B or C (p&amp;lt;0.006 for all). While there was 100% incidence of an immune response to all constructs, the breadth of the response for Construct A was greater than the other two constructs. Class II immunogenicity, in vivo half-life and the percent of the protein in a helical secondary structure can be used to discern the most immunogenic multi-antigen plasmid vaccine construct.
Combinatorial Chemistry Techniques Applied to Nonpeptide lntegrin Antagonists (1998)

The integrins are cell surface receptors that recognize extracellular matrix adhesive proteins such as fibrinogen, fibronectin, vitronectin, and VCAM-1 (vascular cell adhesion molecule-1). Nonpeptide integrin antagonists designed after the adhesion recognition sequence RGD (Arg-Giy-Asp) not only have displayed efficacy as antithrombotic agents, but also have promise for the treatment of cancer and osteoporosis. Combinatorial organic syntheses of chemical mini-libraries have facilitated nonpeptide lead optimization of integrin antagonists with marked success. Although these accomplishments have been realized primarily for the discovery of orally active GPIIb/llla antagonist antithrombotics, vitronectin receptor (α v β 3 ) antagonist research has also benefited from such rapid synthesis. The purpose of this review is to report progress in combinatorial synthesis lead optimization by highlighting the drug design strategies and synthetic tactics that have led to improved integrin antagonists.
Supplementary Figure Legend from A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth <i>In Vitro</i> and <i>In Vivo</i> (2023)

&lt;p&gt;PDF file, 61KB.&lt;/p&gt;
Continuum-Level Analytical Model for Solid Oxide Fuel Cells with Mixed Conducting Electrolytes (2009)

A continuum-level analytical model was developed for the performance of solid oxide fuel cells (SOFCs) with mixed conducting electrolytes. The model was derived by coupling the Nernst–Planck equation for mass transport in the bulk with the Butler–Volmer equation for mass transport across an interface and by employing defect thermodynamics for boundary values. This approach allowed the usual assumptions of reversible electrodes and linear potential gradients (across the electrolyte) to be removed, thereby resulting in boundary defect concentrations that depend on potential (SOFC operating conditions) and allowing non-ohmic responses in mixed conducting electrolytes. Using only three fitting parameters, the authors validated the model through successful fits to experimental data from SOFCs with samaria- and gadolinia-doped ceria electrolytes, which are presently the mixed conducting electrolytes of greatest interest. The fits also allowed valuable information to be extracted from the experimental data regarding the overpotentials in the SOFC. Significantly, the anode, cathode, and electrolyte overpotentials were uniquely determined, each as a function of current. Hence, it was confirmed that performance losses due to electronic leakage through ceria electrolytes is confined to low load (low current and high voltage) conditions. Finally, the model was used to show that open-circuit voltage is a function of electrolyte thickness.
Minimization of solar cell hot-spots on GPS solar arrays using SABER modeling (2002)

The GPS Block IIR solar array originally was designed with circuits consisting of 160 4/spl times/6 cm. silicon solar cells connected as 2 cells in parallel with 80 cells in series. Because each cell in the 2/spl times/80 cell circuits was connected in parallel there was a concern that severe hot spot heating of individual cells could occur under array shadowing conditions. An analog model was developed to simulate solar array operation in order to better the implications of this condition. A number of different circuit topologies were simulated in order to reduce the hot spot heating. Eliminating the parallel connections between each individual cell was found to be the best way to minimize cell heating without resorting to bypass diodes.
Supplemental Table Legends from Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer (2023)

&lt;p&gt;Supplemental Table Legends&lt;/p&gt;
RTX Beyond Ray Tracing: Exploring the Use of Hardware Ray Tracing Cores for Tet-Mesh Point Location (2019)

We explore a first proof-of-concept example of creatively using the Turing generation's hardware ray tracing cores to solve a problem other than classical ray tracing, specifically, point location in unstructured tetrahedral meshes. Starting with a CUDA reference method, we describe and evaluate three different approaches to reformulate this problem in a manner that allows it to be mapped to these new hardware units. Each variant replaces the simpler problem of point queries with the more complex one of ray queries; however, thanks to hardware acceleration, these approaches are actually faster than the reference method.
The Corrosion Performance of Aluminum Automotive Body Panels in Service (1998)

&lt;div class="htmlview paragraph"&gt;An extensive field study was made of the corrosion of aluminum alloy panels in over fifteen years of service in three regions of the USA. Panels removed from service exposed vehicles were subjected to further testing to determine the relationship between field service, accelerated laboratory corrosion testing, and marine environment exposure for two years at Daytona Beach, Florida.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;In addition, two 42 year old aluminum bodied Dyna Panhard vehicles were recovered in France, examined closely, and subjected to similar tests.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Few examples of significant corrosion were found in the field, and only one example of filiform corrosion on aluminum sheet in service. Steel panels on the same vehicles frequently rusted through, and filiform corrosion was seen occasionally. Laboratory tested aluminum panel samples frequently showed filiform corrosion and severe intergranular corrosion. No filiform corrosion on recovered panels has been observed to date at the Daytona Beach site, although some laboratory prepared samples exhibit general corrosion. Performance of aluminum alloy panels is clearly superior to steel.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Many laboratory corrosion tests in current use are far too severe, and do not predict actual service behavior. The relevance of accelerated testing to service behavior is discussed.&lt;/div&gt;
Large-Effective-Area Uncoupled 10-Core Fiber with Two-Pitch Layout (2012)

Characteristics of a 10-core fiber with two-pitch layout were investigated. A core pitch was optimized by simulation. The fabricated fiber realized Aeff larger than 115 μm2 and low-crosstalk characteristics with about 200-μm cladding diameter.
Graft Polymer (2017)

IUPAC recommendations on source-based nomenclature for single-strand polymers have so far addressed its application mainly to copolymers, non-linear polymers and polymer assemblies, and within generic source-based nomenclature of polymers. In this document, rules are formulated for devising a satisfactory source-based name for a polymer, whether homopolymer or copolymer, which are as clear and rigorous as possible. Thus, the source-based system for naming polymers is presented in a totality that serves as a user-friendly alternative to the structure-based system of polymer nomenclature. In addition, because of their widespread and established use, recommendations for the use of traditional names of polymers are also elaborated.
Single-cell analysis of immune cell transcriptome during HIV-1 infection and therapy (2022)

This work identified key molecular pathways that are altered in immune cells during chronic HIV-1 infection that could remain despite therapy. We also identified key genes that are upregulated during early HIV-1 infection that provide insights on the mechanism of HIV-1 infection and could be targets for future therapy.
Large angle beam steering on silicon nanomembrane (2011)

We present a phased waveguide array implementation on silicon-on-insulator based on non-uniform array design. Using individually controlled thermo-optic phase shifters, we demonstrate 31.9° beam steering in free space.
Mechanisms of post-exposure protection mediated by virus-like particles against Ebola virus infection (52.18) (2010)

Abstract Ebola virus causes hemorrhagic fever that is characterized by high viral titers, coagulopathy, and high lethality rates. Our lab has developed a virus-like particle (VLP) vaccine that is effective in mouse, guinea pig, and non-human primate models when given as a pre-exposure vaccine. In this work, we show that VLPs protect Ebola-infected mice when given 24 hours post-infection. We used this platform to analyze mechanisms of immunity for post-exposure protection against Ebola virus. Analysis of serum revealed a decrease in many cytokine levels in mice given VLPs post-exposure compared to infected, untreated mice. VLP-mediated post-exposure protection required B cells, perforin, STAT-1 signaling, and either CD4+ or CD8+ T cells. However, NK cells, IFN-gamma, and TNF-alpha were not required for this protection. Interestingly, transient depletion of macrophages or dendritic cells abrogated VLP-mediated post-exposure protection. Additional studies are underway to further characterize the mechanisms of immunity in this setting.
mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy (2021)

Our findings establish a novel disease, which we call autosomal dominant kidney hypomagnesemia (ADKH-RRAGD), that combines an electrolyte-losing tubulopathy and dilated cardiomyopathy. The condition is caused by variants in the <i>RRAGD</i> gene, which encodes Rag GTPase D; these variants lead to an activation of mTOR signaling, suggesting a critical role of Rag GTPase D for renal electrolyte handling and cardiac function.
Banding Reduction in Electrophotographic Process Using Closed-Loop Controlled Piezoelectric Laser Beam Deflection Device (2000)

Abstract Banding is an image artifact that appears as peroidic light and dark bands across a page. This paper presents an experimental study on the application of a piezoelectric laser beam deflection device to reduce banding in the electrophotographic process. An empirical model was obtained using system identification techniques by measuring the laser beam position on-line using an optical sensor. A closed loop control strategy is then proposed and implemented. Experiments conducted without actually printing showed significant improvements in reducing the scan line positioning errors using the proposed method.
Workshop on Detection and Design for Cognitive Biases in People and Computing Systems (2020)

With social computing systems and algorithms having been shown to give rise to unintended consequences, one of the suspected success criteria is their ability to integrate and utilize people's inherent cognitive biases. Biases can be present in users, systems and their contents. With HCI being at the forefront of designing and developing user-facing computing systems, we bear special responsibility for increasing awareness of potential issues and working on solutions to mitigate problems arising from both intentional and unintentional effects of cognitive biases. This workshop brings together designers, developers, and thinkers across disciplines to redefine computing systems by focusing on inherent biases in people and systems and work towards a research agenda to mitigate their effects. By focusing on cognitive biases from content or system as well as from a human perspective, this workshop will sketch out blueprints for systems that contribute to advancing technology and media literacy, building critical thinking skills, and depolarization by design.
Photonically-enabled imaging receiver (2017)

Recent advances in spatial synchronization of photonically sampled phased array receivers have enabled the creation of massively multibeam non-blocking receivers at microwave and millimeter-wave frequencies. Applications and realizations of these receivers for passive imaging, communications, RADAR, and electronic support in microwave and millimeter-wave frequency spectrum are presented.
Nanoscale thermometry via the fluorescence of YAG:Ce phosphor particles: measurements from 7 to 77 C (2003)

The laser-induced fluorescence lifetime of 30 nm particles of YAG:Ce was measured as a function of temperature from 7 to 77°C. The fluorescence decay lifetimes for the nanoparticles of this phosphor varied from ≈18 to 27 ns, i.e. ≈33% relative to the longest lifetime measured. This large variation in lifetime, coupled with the high signal strength that was observed, suggest that YAG:Ce nanoparticles will be useful thermographic phosphors. We describe the material and the apparatus used to characterize its fluorescence, present the results of measurements made over the range of temperatures tested and comment on some possible applications for this novel material.
Early look at near-real MOPITT data (1999)

The Measurements Of Pollution In The Troposphere (MOPITT) instrument will monitor the global concentrations of carbon monoxide and methane. It will be flown on the Earth Observing Satellite, EOS-AM1, scheduled for launch late in 1999. This paper describes the analysis of a twenty four hour data set that was recorded during the latter stages of testing at the University of Toronto Instrument Characterization Facility (ICF). This data set represents the best 'near real time' contiguous data available and it is being used to help understand the instrument behavior and characteristics, as well as with algorithm development with the goal of the University of Toronto team being to determine the gain, offset and noise parameters for all channels from the in-flight calibration system.
Defining the role of the novel CD4+CD26high T cell subset in adoptive cancer immunotherapy (VAC11P.1001) (2014)

Abstract Th17 cells mediate exquisite tumor eradication upon transfer into mice bearing large, established melanoma. Unfortunately, the polarizing cytokines (TGF-β, IL-6, etc.) required to generate Th17 cells are not yet FDA approved for clinical use. Therefore, we sought to determine if these IL-17-producing CD4+ cells could be enriched from peripheral blood. Herein, we found that functional Th17 cells could be isolated from blood, without the need for polarization, by using the surface marker CD26. Excitingly, very few (5e4 cells) of these CD26-rich cells, termed CD26high T cells, displayed striking antitumor activity and survival upon transfer into melanoma-bearing mice compared to CD26negative or bulk CD4+ T cells. Of translational significance, we found that human CD26high cells had heightened cytotoxicity and caused greater cancer cell death in vitro. Interestingly, both murine and human CD26high T cells boast a unique phenotype compared to their bulk CD4+ or CD26negative counterparts, including: enhanced expression of the cytokines IL-17, IFN-γ, and IL-22, transcription factors RORγ and Tbet, and cytokine receptors CD25, CD122, and CD127. Collectively, these findings describe a novel T cell subset that has promise in cell-based cancer therapies due to its unique polyfunctionality and engraftment. Moreover, enrichment of CD26high T cells from peripheral blood bypasses the need for polarization, thereby enhancing the translational potential for Th17 cells in immunotherapy.