gebhart/patrepeval huggingface dataset:
ASEDRA Evaluation Final Report. (2008)

The performance of the Advanced Synthetically Enhanced Detector Resolution Algorithm (ASEDRA) was evaluated by performing a blind test of 29 sets of gamma-ray spectra that were provided by DNDO. ASEDRA is a post-processing algorithm developed at the Florida Institute of Nuclear Detection and Security at the University of Florida (UF/FINDS) that extracts char-acteristic peaks in gamma-ray spectra. The QuickID algorithm, also developed at UF/FINDS, was then used to identify nuclides based on the characteristic peaks generated by ASEDRA that are inferred from the spectra. The ASEDRA/QuickID analysis results were evaluated with respect to the performance of the DHSIsotopeID algorithm, which is a mature analysis tool that is part of the Gamma Detector Response and Analysis Software (GADRAS). Data that were used for the blind test were intended to be challenging, and the radiation sources included thick shields around the radioactive materials as well as cargo containing naturally occurring radio-active materials, which masked emission from special nuclear materials and industrial isotopes. Evaluation of the analysis results with respect to the ground truth information (which was provided after the analyses were finalized) showed that neither ASEDRA/QuickID nor GADRAS could identify all of the radiation sources correctly. Overall, the purpose of this effort was primarily to evaluate ASEDRA, and GADRAS was used as a standard against which ASEDRA was compared. Although GADRAS was somewhat more accurate on average, the performance of ASEDRA exceeded that of GADRAS for some of the unknowns. The fact that GADRAS also failed to identify many of the radiation sources attests to the difficulty of analyzing the blind-test data that were used as a basis for the evaluation. This evaluation identified strengths and weaknesses of the two analysis approaches. The importance of good calibration data was also clear because the performance of both analysis methods was impeded by the inability to define the energy calibration accurately. Acronyms ACHIP adaptive chi-processed ASEDRA Advanced Synthetically Enhanced Detector Resolution Algorithm DNDO Domestic Nuclear Detection Office DRFs Detector Response Functions FINDS Florida Institute of Nuclear Detection and Security FWHM full-width half-maximum GADRAS Gamma Detector Response Analysis Software GUI graphical user interface HEU highly enriched uranium HPGe high purity germanium ID identification NaI Sodium iodide NNSA National Nuclear Security Administration NORM Naturally Occurring Radioactive Materials ppm parts per million SNL Sandia National Laboratories UF University of Florida WGPu weapons-grade plutonium
Redox Behavior of Ni-Yttria Stabilized Zirconia (YSZ) Cermets and Oxygen Gas Shielding Properties (1997)

The influences of redox treatments on the mechanical and gas permeable properties of Ni-yttria stabilized zirconia (YSZ) cermets were investigated. The bending strength decreased successively with the continuous redox treatments. The porosity and the mean pore diameter increased by the first reduction, decreased to be close to the initial levels by the subsequent oxidation, and then again increased by the second reduction. With the oxidation treatment, the surface region of the cermet disk restored the tight microstructure consisting of well-packed grains, while the inside remained porous. This preferential oxidation in the surface region resulted in the negligibly small permeation of nitrogen gas, indicating a possibility of utilizing the cermets a shielding membrane against oxygen permeation. The oxygen gas shielding was experimentally confirmed to occur at around 500°C.
Continuous wave Doppler echocardiographic measurement of prosthetic valve gradients. A simultaneous Doppler-catheter correlative study. (1989)

Studies correlating prosthetic valve gradients determined by continuous wave Doppler echocardiography with gradients obtained by cardiac catheterization have, to date, been limited to patients with mitral and tricuspid prostheses or have compared nonsimultaneous measurements. Simultaneous Doppler and catheter pressure gradients in 36 patients (mean age, 63 +/- 13 years) with 42 prosthetic valves (20 aortic, 20 mitral, one tricuspid, and one pulmonary) were studied. Catheter gradients were obtained using a dual-catheter technique. The simultaneous pressure tracings and Doppler flow velocity profiles were digitized at 10-msec intervals to derive the corresponding maximal and mean gradients. The correlation between the maximal Doppler gradient and the simultaneously measured maximal catheter gradient was 0.94 (SEE = 6), and that between the Doppler gradient and the simultaneously measured mean catheter gradient was 0.96 (SEE = 3). There were no significant differences in correlation between gradients for the 32 mechanical valves (maximal gradients: r = 0.95, SEE = 6; mean gradients: r = 0.96, SEE = 3) and the 10 bioprosthetic valves (maximal gradients: r = 0.89, SEE = 6; mean gradients: r = 0.93, SEE = 3). In patients with mitral prostheses, Doppler gradients correlated well with the corresponding catheter gradients obtained with direct measurement of left atrial pressure (maximal gradients: r = 0.96, SEE = 2; mean gradients: r = 0.97, SEE = 1.2). A close correlation between corresponding Doppler and catheter gradients also was found in patients with aortic prostheses (maximal gradients: r = 0.94, SEE = 6; mean gradients: r = 0.94, SEE = 3). Thus, continuous wave Doppler echocardiography can accurately predict the pressure gradient across prosthetic valves.
Simplified Transition and Turbulence Modeling for Oscillatory Pipe Flows (2021)

One-dimensional unsteady Reynolds-averaged Navier–Stokes computations were performed for oscillatory transitional and turbulent pipe flows and the results were validated against existing experimental data for a wide variety of oscillatory Reynolds and Womersley numbers. An unsteady version of the Johnson–King model was implemented with optional near-wall modification to account for temporal pressure gradient variations, and the predictions were compared with those of the Spalart–Allmaras and k–ε turbulence models. Transition and relaminarization were based on empirical Womersley number correlations and assumed to occur instantaneously: in the former case, this assumption was valid, but in the latter case, deviations between data and predictions were observed. In flows where the oscillatory Reynolds numbers are substantially higher than the commonly accepted steady critical value (~2000), fully or continuously turbulent models produced the best correspondence with experimental data. Critically and conditionally turbulent models produced slightly inferior correspondence, and no significant benefit was observed when near-wall pressure gradient effects were implemented or when common one- and two-equation turbulence models were employed. The turbulent velocity profiles were mainly unaffected by the oscillations and this was explained by noting that the turbulent viscosity is significantly higher than its laminar counterpart. Thus, a turbulent Womersley number was proposed for the analysis and categorization of oscillatory pipe flows.
100G solution tailored for 5G based upon CAPS3 (2017)

CAPS-3 modulation format is used in 100G system for 5G applications. CAPS-3 is simple to generate, can be direct detected, and is able to defeat any significant amount of chromatic dispersion, without the need of digital signal processing in a distance range between 10 and 20 km.
Stress-induced proteins of Agrobacterium tumefaciens (2001)

The pattern of proteins produced by bacteria represents the physiological state of the organism as well as the environmental conditions encountered. Environmental stress induces the expression of several regulons encoding stress proteins. Extensive information about the proteins which constitute these regulons (or stimulons) and their control is available for very few bacteria, such as the Gram-positive Bacillus subtilis and the Gram-negative Escherichia coli (gamma-proteobacteria) and is minimal for all other bacteria. Agrobacterium tumefaciens is a Gram-negative plant pathogen of the alpha-proteobacteria, which constitutes the main tool for plant recombinant genetics. Our previous studies on the control of chaperone-coding operons indicated that A. tumefaciens has unique features and combines regulatory elements from both B. subtilis and E. coli. Therefore, we examined the patterns of proteins induced in A. tumefaciens by environmental changes using two-dimensional gel electrophoresis and dual-channel image analysis. Shifts to high temperature, oxidative and mild acid stresses stimulated the expression of 97 proteins. The results indicate that most of these stress-induced proteins (80/97) were specific to one stress stimulon. Only 10 proteins appear to belong to a general stress regulon.
Backward amplified spontaneous emission from erbium-doped fibers as a measure of amplifier efficiency (1993)

Optical amplifiers using erbium-doped fibers (EDF’s) are attractive for lightwave communications, especially because of the high gain and high output power they can provide at 1.5 µm. The rapid progress in the development of erbium-doped-fiber amplifiers (EDFA’s) has led to the planning of many lightwave systems, both undersea and terrestrial. EDF performance is a key element in designing these systems. Optimization of the fiber conversion efficiency is particularly critical for lowering the required pump power, which results in increased pump reliability and lower power consumption.
Loading-Dependent Transport Properties of Zeolitic Imidazolate Frameworks Probed by In-Situ PFG NMR (2011)

Zeolitic imidazolate frameworks (ZIFs), a unique subclass of metal‐organic frameworks (MOFs) recently reported by Yaghi group and others, are attracting worldwide attention. Our systematic work on the adsorption and molecular transport in ZIFs has revealed some unique properties of these new materials that could not have been anticipated from standard structural characterization results. More specifically, the rearrangement of the imidazolate linkers (and in some cases, the framework structure) driven by adsorbate‐adsorbent interaction causes the window sizes and accessible pore space of ZIFs to deviate (in some cases, drastically) from the values determined by low‐temperature single‐crystal X‐ray crystallography and typical physisorption experiments carried out at liquid nitrogen temperature (77 K) with H2, N2 and Ar. Here we show the high degree of structural flexibility of ZIFs at near ambient temperatures and report the first time their unique adsorption and transport characteristics.
Influence function based Gaussianity tests for detection of microcalcifications in mammogram images (2003)

In this paper, computer-aided diagnosis of microcalcifications in mammogram images is considered. Microcalcification clusters are an early sign of breast cancer. Microcalcifications appear as single bright spots in mammogram images. We propose an effective method for the detection of these abnormalities. The first step of this method is two-dimensional adaptive filtering. The filtering produces an error image which is divided into overlapping square regions. In each square region, a Gaussianity test is applied. Since microcalcifications have an impulsive appearance, they are treated as outliers. In regions with no microcalcifications, the distribution of the error image is almost Gaussian, on the other hand, in regions containing microcalcification clusters, the distribution deviates from Gaussianity. Using the theory of the influence function and sensitivity curves, we develop a Gaussianity test. Microcalcification clusters are detected using the Gaussianity test. Computer simulation studies are presented.
Hardware-Limited Non-Uniform Task-Based Quantizers (2023)

Hardware-limited task-based quantization is a new design paradigm for data acquisition systems equipped with scalar analog-to-digital converters using a small number of bits. By taking into account the system task, task-based quantizers can efficiently recover the desired parameters from the low-bit quantized observation. Current design and analysis frameworks for hardware-limited task-based quantization are only applicable to inputs with bounded support and uniform quantizers with non-subtractive dithering. In this paper, we propose a new framework based on generalized Bussgang decomposition that enables the design and analysis of hardware-limited task-based quantizers equipped with non-uniform scalar quantizers or have inputs with unbounded support. We consider the scenario in which the task is linear. Under this scenario, we derive new pre-quantization and post-quantization mappings for task-based quantizers with mean squared error (MSE) that closely matches the theoretical MSE.
Variability in photocoagulation treatment of diabetic macular oedema (2012)

Diabetic macular oedema photocoagulation treatment threshold and dosage of laser spots differ depending on whether thickness assessments are based on stereoscopic slit-lamp biomicroscopy or OCT. In addition, retinal specialists differed in the number and placement of planned laser spots even when given identical information concerning DME and treatable lesions. This variability in the photocoagulation treatment of DME could lead to differences in patient outcome and laser study results.
A substrate selected by phage display exhibits enhanced side-chain hydrogen bonding to HIV-1 protease (2018)

Crystal structures of inactive variants of HIV-1 protease bound to peptides have revealed how the enzyme recognizes its endogenous substrates. The best of the known substrates is, however, a nonnatural substrate that was identified by directed evolution. The crystal structure of the complex between this substrate and the D25N variant of the protease is reported at a resolution of 1.1 Å. The structure has several unprecedented features, especially the formation of additional hydrogen bonds between the enzyme and the substrate. This work expands the understanding of molecular recognition by HIV-1 protease and informs the design of new substrates and inhibitors.
Toward Physicochemical and Rheological Characterization of Different Injectable Hyaluronic Acid Dermal Fillers Cross-Linked with Polyethylene Glycol Diglycidyl Ether (2021)

(1) Background: Injectable hyaluronic acid (HA) dermal fillers are used to restore volume, hydration and skin tone in aesthetic medicine. HA fillers differ from each other due to their cross-linking technologies, with the aim to increase mechanical and biological activities. One of the most recent and promising cross-linkers is polyethylene glycol diglycidyl ether (PEGDE), used by the company Matex Lab S.p.A., (Brindisi, Italy) to create the HA dermal filler PEGDE family. Over the last few years, several studies have been performed to investigate the biocompatibility and biodegradability of these formulations, but little information is available regarding their matrix structure, rheological and physicochemical properties related to their cross-linking technologies, the HA content or the degree of cross-linking. (2) Methods: Seven different injectable HA hydrogels were subjected to optical microscopic examination, cohesivity evaluation and rheological characterization in order to investigate their behavior. (3) Results: The analyzed cross-linked dermal fillers showed a fibrous "spiderweb-like" matrix structure, with each medical device presenting different and peculiar rheological features. Except for HA non cross-linked hydrogel 18 mg/mL, all showed an elastic and cohesive profile. (4) Conclusions: The comparative analysis with other literature works makes a preliminary characterization of these injectable medical devices possible.
Security analysis of Bloom filter-based iris biometric template protection (2015)

This paper analyses the unlinkability and the irreversibility of the iris biometric template protection system based on Bloom filters introduced at ICB 2013. Hermans et al. presented at BIOSIG 2014 an attack on the unlinkability of these templates. In the worst case, their attack succeeds with probability at least 96%. But in their attack, they assume protected templates generated from the same iriscode. In this paper, we analyze unlinkability on protected templates generated with two different iriscodes coming from the same iris, and we moreover introduce irreversibility analysis that exploits non-uniformity of the data. Our experiments thus practically demonstrate new vulnerabilities of the scheme.
Saccharomyces cerevisiae Requires CFF1 To Produce 4-Hydroxy-5-Methylfuran-3(2H)-One, a Mimic of the Bacterial Quorum-Sensing Autoinducer AI-2 (2021)

Quorum sensing is a process of cell-to-cell communication that bacteria use to orchestrate collective behaviors. Quorum sensing depends on the production, release, and detection of extracellular signal molecules called autoinducers (AIs) that accumulate with increasing cell density. While most AIs are species specific, the AI called AI-2 is produced and detected by diverse bacterial species, and it mediates interspecies communication. We recently reported that mammalian cells produce an AI-2 mimic that can be detected by bacteria through the AI-2 receptor LuxP, potentially expanding the role of the AI-2 system to interdomain communication. Here, we describe a second molecule capable of interdomain signaling through LuxP, 4-hydroxy-5-methylfuran-3(2H)-one (MHF), that is produced by the yeast <i>Saccharomyces cerevisiae</i> Screening the <i>S. cerevisiae</i> deletion collection revealed Cff1p, a protein with no known role, to be required for MHF production. Cff1p is proposed to be an enzyme, with structural similarity to sugar isomerases and epimerases, and substitution at the putative catalytic residue eliminated MHF production in <i>S. cerevisiae</i> Sequence analysis uncovered Cff1p homologs in many species, primarily bacterial and fungal, but also viral, archaeal, and higher eukaryotic. Cff1p homologs from organisms from all domains can complement a <i>cff1Δ</i><i>S. cerevisiae</i> mutant and restore MHF production. In all cases tested, the identified catalytic residue is conserved and required for MHF to be produced. These findings increase the scope of possibilities for interdomain interactions via AI-2 and AI-2 mimics, highlighting the breadth of molecules and organisms that could participate in quorum sensing.<b>IMPORTANCE</b> Quorum sensing is a cell-to-cell communication process that bacteria use to monitor local population density. Quorum sensing relies on extracellular signal molecules called autoinducers (AIs). One AI called AI-2 is broadly made by bacteria and used for interspecies communication. Here, we describe a eukaryotic AI-2 mimic, 4-hydroxy-5-methylfuran-3(2H)-one, (MHF), that is made by the yeast <i>Saccharomyces cerevisiae</i>, and we identify the Cff1p protein as essential for MHF production. Hundreds of viral, archaeal, bacterial, and eukaryotic organisms possess Cff1p homologs. This finding, combined with our results showing that homologs from all domains can replace <i>S. cerevisiae</i> Cff1p, suggests that like AI-2, MHF is widely produced. Our results expand the breadth of organisms that may participate in quorum-sensing-mediated interactions.
Light Damage in the Developing Rat Retina (1976)

The effect of bright light on the retinas of developing albino rats was studied electron microscopically. The newly formed outer-segment lamellar membranes of newborn rats raised in continuous bright light appear to be less sensitive to the damaging effects of light, compared to those of rats raised under normal light conditions for at least two weeks. It seems to take about two days before the membranes show damage from continuous exposure to fluorescent lamps. The same brightness damages the adult outer segments within a few hours. Despite the severe damage to the outer segments, the rest of the retina develops normally for one month, and then the photoreceptor cells undergo degeneration. The retinas that have been exposed to bright light for two weeks after birth show considerable damage, but these retinas regenerate in six months.
<title>Performance and complexity analysis of rate-constrained motion estimation in MPEG-4</title> (1999)

Motion estimation constitutes a critical part in video coding since it is computationally expensive and has a substantial impact on the resulting image quality. A very efficient method to estimate motion is through adding a rate constraint for coding of the motion vectors into the estimation process. In this paper we analyze the performance of this approach in the emerging MPEG-4 standard, considering frame- as well as object-based video sequences. The investigations show that rate constrained motion estimation generally offers significant gains in coding efficiency which, however, depend on the shape of the object coded. Complexity measurements further show that a rate constraint imposes only a marginal computational overhead, thus making this approach a useful amendment for an MPEG-4 coder.
100th Anniversary of Macromolecular Science Viewpoint: Polymerization of Cumulated Bonds: Isocyanates, Allenes, and Ketenes as Monomers (2020)

Polymer chemistry offers exciting opportunities to tailor the properties of soft materials through control of the composition of the polymers and their interaction with each other, additives, and surfaces. Ongoing advances in the synthesis of polymeric materials demonstrate the drive for materials with tailored properties for enhanced performance in the next generation of materials and devices. One class of small molecules that can serve as monomers in chain growth polymerization are cumulated double bonds of the general form X═Y═Z. The three most common classes of these molecules are isocyanates (N═C═O), allenes (C═C═C), and ketenes (C═C═O), each of which has been explored as monomers under a variety of conditions. The orthogonality of the two pi bonds of the cumulated double bonds (i.e., lack of conjugation) enables the formation of different polymer backbones from a single monomer, provided the regioreactivity is controlled. This Viewpoint outlines the use of these three cumulated double bonds as monomers, illustrating success and current limitations to established polymerization methods. We then provide an outlook to the future of cumulated double bonds as monomers for the generation of tailored polymer compositions.