gebhart/patrepeval huggingface dataset:
Clinical and Product Features Associated with Outcome of DLBCL Patients to CD19-Targeted CAR T-Cell Therapy (2021)

CD19-directed CAR T-cells have been remarkably successful in treating patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and transformed follicular lymphoma (t-FL). In this cohort study, we treated 60 patients with axicabtagene ciloleucel or tisagenlecleucel. Complete and partial metabolic responses (CMR/PMR) were obtained in 40% and 23% of patients, respectively. After 6.9 months of median follow-up, median progression-free survival (mPFS) and overall survival (mOS) were estimated at 3.1 and 12.3 months, respectively. Statistical analyses revealed that CMR, PFS, and OS were all significantly associated with age-adjusted international prognostic index (aaIPI, <i>p</i> < 0.05). T-cell subset phenotypes in the apheresis product tended to correlate with PFS. Within the final product, increased percentages of both CD4 and CD8 CAR<sup>+</sup> effector memory cells (<i>p</i> = 0.02 and 0.01) were significantly associated with CMR. Furthermore, higher CMR/PMR rates were observed in patients with a higher maximal in vivo expansion of CAR T-cells (<i>p</i> = 0.05) and lower expression of the LAG3 and Tim3 markers of exhaustion phenotype (<i>p</i> = 0.01 and <i>p</i> = 0.04). Thus, we find that aaIPI at the time of infusion, phenotype of the CAR T product, in vivo CAR T-cell expansion, and low levels of LAG3/Tim3 are associated with the efficacy of CAR T-cell therapy in DLBCL patients.
Nonlinear systems analysis of the hippocampal perforant path-dentate projection. I. Theoretical and interpretational considerations (1988)

1. Nonlinear systems analytic procedures, based on an orthogonalized functional power series approach, were developed for study of the transformational properties of the hippocampal formation. As a testing stimulus, the procedures utilize a train of electrical impulses with randomly varying interimpulse intervals. The specific case was considered of applying such a stimulus to the perforant path, a major afferent to the hippocampal dentate gyrus that arises from the entorhinal cortex. Resulting field potentials evoked within the dentate gyrus are recorded to all impulses in the train. Computational algorithms based on cross-correlations determine the relationship between the interimpulse interval within the random train and amplitude of the evoked dentate potentials. The calculations, which reduce to averaging procedures, were derived for first- and second-order terms, or kernels, of the orthogonalized functional power series. 2. It is proposed that such an approach can be applied to a single component of the complex field potential evoked in the dentate gyrus. This component, the population spike, reflects the action potential discharge of dentate granule cells. Thus, a field potential component for which the underlying neuronal generator is well-known can be analyzed with respect to the transformational characteristics of the network of neurons that influence that generator. Other components of the complex field potential produced by other generators can be ignored. It is shown that this adaptation has the effect of greatly simplifying both the computation and presentation of kernels. 3. As a further consequence of this adaptation, the resulting first- and second-order kernels were shown to have specific interpretations. The first-order kernel represents the average response of the orthodromically driven granule cells to the set of stimuli comprising the random impulse train. The second-order kernel quantitatively characterizes the nonlinearity of the granule cell response, and may be interpreted as a generalized recovery function; i.e., the first input of any pair of stimuli in the train activates the newtork, and the second input tests the modulatory influence of the network excited by the initial input. 4. Most past investigations of nonlinearities of the perforant path-dentate projection have utilized pairs of stimulus impulses. We show here that, for a second-order system, the expected results from paired impulse experiments may be predicted from second-order kernels. Disagreement between the measured and predicted results reflects interactions of a higher order, and thus, greater system complexity.(ABSTRACT TRUNCATED AT 400 WORDS)
Neurology: Genetics Year in Review (2021)

As in the past years, the editors of Neurology® Genetics have chosen articles from our journal and from other publications that we believe deserve highlighting for our readers. The reports cover a variety of mutational mechanisms and diseases as well as novel aspects of clinical phenotypes and neuroimaging.
Study of mask-induced polarization effects on att. PSM in immersion lithography (2006)

The immersion lithography for 45 nm generation has been developing aggressively for smaller critical dimension of semiconductor devices. The polarization lithography system is indispensable to have an advantage to use the immersion lithography with hyper NA (>1.0). As pattern size becomes smaller, mask induced polarization effects to polarization of exposure image seems not to be negligible. There are several issues about mask induced polarization. But dominant factor for mask induced polarization effect is not understood well. In this paper, in case of monolayer mask of att.PSM, degree of polarization (DoP) strongly depends on film thickness and extinction coefficient from simulation and experimental results. DoP depends on material factor. And in case of double layer mask, DoP depends on total film thickness and extinction coefficient of both upper layer and bottom layer. So, DoP depends also on structure of mask.
Improvement of Electrode/ Electrolyte Interfaces in Graphite/LiNi0.5Mn1.5O4 Batteries at High Voltage and Elevated Temperature By Using New Family of Lithium Pyridal Trimethyl Borates (2016)

A novel series or lithium alkyl trimethyl borates and lithium aryl trimethyl borates have been prepared and investigated as cathode film forming additives. The borates are prepared via the reaction of lithium alkoxides or lithium phenoxides with trimethyl borate. Incorporation of 0.5-2.0 % (wt) of the lithium borates to a baseline electrolyte (1.0 M LiPF 6 in 3:7 (EC/EMC)) results in improved capacity retention and efficiency of high voltage graphite / LiNi 0.5 Mn 1.5 O 4 cells especially upon cycling at elevated temperature (55 o C). The improved performance results from the sacrificial oxidation of the lithium borate on the cathode surface to generate a cathode passivation film. The lithium borates can be readily structurally modified to act as a functional group delivery agent to modify the cathode surface. Ex-situ surface analysis of the electrodes after cycling confirms that the lithium borates modify the cathode surface and generate a borate rich surface film which inhibits electrolyte oxidation and Mn dissolution.
15-THz pulse generation arising from modulation instability oscillation in a colliding-pulse mode-locking dye laser (1989)

15-THz trains of a few-tens-of-femtoseconds optical pulses were generated by modulation instability oscillation in a colliding-pulse mode-locked dye laser. A repeatable and stable modulation instability regime was obtained with the laser operating in the anomalous-dispersion regime and with a low saturable-absorber concentration. Autocorrelation measurements indicate that subpulses were completely separated in real time. Variations of the modulation with the pump power and the amount of dispersion in the cavity are in good agreement with modulation instability theory.
Validity of an acoustic method to assess whole-body hydration status (2015)

Athletes and the elderly are two populations that are at an increased risk of dehydration related illness or injury. The purpose of this study was to evaluate the validity of an acoustic method to detect changes in the hydration status of athletes undergoing acute dehydration and rehydration. The presence or absence of dehydration in elderly individuals throughout the day and between days, was also examined. The assessment of water balance was conducted by measuring speed of ultrasound in the calf muscles using a through transmission method. 82 male and female collegiate athletes and 20 elderly individuals were assessed. Results revealed an average change in ultrasound velocity of 1.1 m/s per 1% of body weight lost. This demonstrates that ultrasound velocity in muscle may potentially serve as a measure of body hydration status during acute dehydration and as a diagnostic tool in the elderly. However, the ultrasound velocity measurement method used in this study is highly dependent on the positioning of the probe: even slight variation in the acoustic path results in significant changes in the measured values, which may result in unacceptable error. A solution to this problem is proposed and discussed.
Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia (2005)

The PARK2 gene, previously identified as a mutated target in patients with autosomal recessive juvenile parkinsonism (ARJP), has recently been found to be a candidate tumor suppressor gene in ovarian, breast, lung and hepatocellular carcinoma that maps to the third common fragile site (CFS) FRA6E. PARK2 is linked to a novel described PACRG gene by a bidirectional promoter containing a defined CpG island in its common promoter region. We have studied the role of promoter hypermethylation in the regulation of PARK2 and PACRG expression in different tumor cell lines and primary patient samples. Abnormal methylation of the common promoter of PARK2 and PACRG was observed in 26% of patients with acute lymphoblastic leukemia and 20% of patients with chronic myelogenous leukemia (CML) in lymphoid blast crisis, but not in ovarian, breast, lung, neuroblastoma, astrocytoma or colon cancer cells. Abnormal methylation resulted in downregulation of PARK2 and PACRG gene expression, while demethylation of ALL cells resulted in demethylation of the promoter and upregulation of PARK2 and PACRG expression. By FISH, we demonstrated that a lack of PARK2 and PACRG expression was due to biallelic hypermethylation and not to deletion of either PARK2 or PACRG in ALL. In conclusion, our results demonstrate for the first time that the candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm.
The Resistance of Polyelectrolyte Multilayers in a Free-Hanging Configuration (2010)

The resistivity ρ(PEM) of polyelectrolyte multilayers (PEMs), PEI(PSS/PAH)(24), PEI(PGA/PAH)(12), PEI(HA/PLL)(12) and PEI(PSS/PLL)(12), in a free-hanging configuration was estimated combining electrochemical impedance spectroscopy (EIS) and atomic force microscopic (AFM) images. Surprisingly, the obtained value of several kΩcm is at least 6 orders of magnitude lower than that reported previously, where the resistivity was determined in the conventional PEM-on-electrode system. The significant discrepancy indicates the unexpectedly low electrical PEM resistance in the absence of redox-active ions and the sensitivity limitation in the conventional system.
Generating consistent updates for software-defined network configurations (2014)

This paper addresses the problem of consistently updating network configurations in a software-defined network. We are interested in generating an update sequence ordering that guarantees per-packet consistency. We present a procedure that computes a safe update sequence by generating an add-before rule dependency graph. Nodes in the graph correspond to rules to be installed and edges capture dependency relations among them.
ChemInform Abstract: Unusual Medium Effect on the Distribution of 1,2,3‐Selenadiazole Regioisomers in the Reaction of N‐Benzyl‐4‐homopiperidinone Semicarbazone with Selenium Dioxide. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
No Substitute for the "P" Word in Financial Rescue (2009)

Fears of pricing troubled assets have needlessly stalled the rescue effort, according to Lawrence Ausubel and Peter Cramton, two market-design economists whose work on TARP has received the attention of the Treasury and policy makers.
Medial Gastrocnemius Flap in the Course of Treatment for an Infection at the Site of a Total Knee Arthroplasty (2017)

Tetreault, Matthew W. MD; Della Valle, Craig J. MD; Hellman, Michael D. MD; Wysocki, Robert W. MD Author Information
Supplementary Data from Phase I Study of Ipilimumab, an Anti–CTLA-4 Monoclonal Antibody, in Patients with Relapsed and Refractory B-Cell Non–Hodgkin Lymphoma (2023)

Supplementary Data from Phase I Study of Ipilimumab, an Anti–CTLA-4 Monoclonal Antibody, in Patients with Relapsed and Refractory B-Cell Non–Hodgkin Lymphoma
Experimental Modeling of Passive Drug Absorption by Capillary Electrophoresis using Liposomal, Micellar and Microemulsion Electrolytes (2004)

Experimental Modeling of Passive Drug Absorption by Capillary Electrophoresis using Liposomal, Micellar and Microemulsion Electrolytes
Relay OFDMA resource allocation methods for wireless monitoring sensor networks (WMSNs) (2016)

This paper focuses on the wireless monitoring sensor networks (WMSNs), where provide relay connectivity for the low capacity and power devices to monitor or sense the events in a monitoring area. In this paper, we propose the relay OFDMA resource allocation methods of coloring resource allocation, static resource allocation and dynamic resource allocation to improve the finite resource of time and frequency. Moreover, this paper studies the performance of the proposed resource allocations in terms of the throughput and delay. Based on the simulation studies, the combination of the coloring and dynamic resource allocation methods provides the superior performance of the throughput and delay for the WMSNs.
A Solid-State Conceptualization of Information Transfer from Gene to Message to Protein (2017)

In this review, we describe speculative ideas and early stage research concerning the flow of genetic information from the nuclear residence of genes to the disparate, cytoplasmic sites of protein synthesis. We propose that this process of information transfer is meticulously guided by transient structures formed from protein segments of low sequence complexity/intrinsic disorder. These low complexity domains are ubiquitously associated with regulatory proteins that control gene expression and RNA biogenesis, but they are also found in the central channel of nuclear pores, the nexus points of intermediate filament assembly, and the locations of action of other well-studied cellular proteins and pathways. Upon being organized into localized cellular positions via mechanisms utilizing properly folded protein domains, thereby facilitating elevated local concentration, certain low complexity domains adopt cross-β interactions that are both structurally specific and labile to disassembly. These weakly tethered assemblies, we propose, are built to relay the passage of genetic information from one site to another within a cell, ensuring that the process is of extreme fidelity.
Synthesis of Novel Imidazobenzodiazepines as Probes of the Pharmacophore for "Diazepam-Insensitive" GABAA Receptors (1995)

The syntheses of a series of novel imidazobenzodiazepines and their affinities for diazepam sensitive (DS) and diazepam insensitive (DI) GABAA receptors are described. Imidazobenzodiazepines belong to one of the very few chemical families which exhibit high to moderate potency for DI GABAA receptors. Although imidazobenzodiazepines such as Ro 15-4513, 20, are the most potent DI GABAA receptor ligands described to date, their selectivity for DI versus DS GABAA receptors is only marginal. Previous structure-activity relationship (SAR) studies of imidazobenzodiazepines have indicated that the 3- and 8-positions are critical for high-affinity binding to DI GABAA receptors (J. Med. Chem. 1993, 36, 479-490. J. Med. Chem. 1993, 36, 1001-1006. J. Med. Chem. 1993, 36, 1820-1830). In order to determine why the ester function is critical to high affinity at the DI site, we have synthesized several derivatives which have substituents other than an ester at the C(3) position including 3-alkyl-, 3-alkylketo-, 3-alkyl ether, and 3-dialkylamino-substituted imidazobenzodiazepines. The SAR analysis of these compounds when combined with that of several pyrazoloquinolinones indicates that interactions at H1 and L1 as well as interactions at H2 anti to the imidazole N(2) and at a lipophilic pocket (labeled LDi) about the 3-position are required in order for imidazobenzodiazepines to exhibit selectivity and high affinity for DI GABAA receptors. Furthermore, the imidazobenzodiazepines substituted with an electron-donating group (alkoxy function) at position 8 revealed that the change of the substituent at C(8) from an electron-withdrawing to a donating function did not substantially alter either ligand affinity or selectivity for DI GABAA receptors. Thus, a pharmacophore is proposed for DI GABAA receptor ligands, which is characterized by the requirement of a lipophilic pocket LDi about the C(3) position of imidazobenzodiazepines. Using this model, two pyrazoloquinolinone derivatives were designed and synthesized. Their affinities and selectivities for DI GABAA receptors are consistent with those predicted by the DI GABAA receptor pharmacophore. In addition, examination of the in vitro binding data of 3-alkyl ether analogs confirms that the anti conformation of the ester group at the C(3) position of imidazobenzodiazepines (Ro15-4513, 20 series) is preferred at both DI and DS GABAA receptors. This constitutes the first evidence (other than molecular modeling) to support the auxillary involvement of H2 at the DI site and is important with regard to the synthesis of other DI GABAA receptor selective ligands in the future.(ABSTRACT TRUNCATED AT 400 WORDS)
Identification of circRNAs linked to Alzheimer’s disease and related dementias (2022)

ABSTRACT We conducted a circular-transcriptome-wide analysis and examined circRNA expression patterns associated with AD and clinical and neuropathological AD severity measures in human hippocampus and cortex brain regions. We validated prior studies of circRNA in AD cortex, and demonstrate novel patterns of expression in the AD hippocampus. We also examined circRNA expression across multiple types of dementia and show that circRNA expression differs by dementia subtype. We demonstrate robust circRNA expression in human neuronal precursor cells (NPCs). Then, using NPCs to study qPCR validated circRNA, we show that exposure to oligomeric tau elicits downregulation of circRNA similar to that observed in AD brain. These data identify circRNA that are changed with AD, and suggest that treating neuronal cells with oligomeric tau can recapitulate some of these changes.
Impact of Major RF Impairments on mm-Wave Communications Using OFDM Waveforms (2016)

In this paper, we study the joint impact of three major RF impairments, namely, oscillator phase noise, power amplifier nonlinearity and I/Q imbalance on the performance of a mm-wave communication link based on OFDM modulation. General impairment models are first derived for describing the joint effects in each TX, each RX as well as a mm-wave communication link. Based on the obtained signal models and initial air interface de-sign from the mmMAGIC project, we numerically evaluate the impact of RF impairments on channel estimation in terms of channel-to-noise ratio (CNR) and also channel fluctuation due to common phase error (CPE) caused by phase noise within the channel coherence time. Then the impact on the link performance in terms of maximum sum rate is evaluated using extensive com-puter simulations. The simulation results show that the used air interface design is generally robust to the presence of RF impair-ments. With regard to the use of high order modulation alphabet and implementation of low-power and low-cost RF transceivers in mm-wave communication, special attention needs to be paid on phase noise where the inter-carrier-interference (ICI) can become a major limiting factor.
Zero TEMR bone imaging in the head (2015)

PD-weighted ZT imaging provides robust and efficient depiction of bone structures in the head, with an excellent contrast between air, soft-tissue, and bone. Besides structural bone imaging, the presented method is expected to be of relevance for attenuation correction in positron emission tomography (PET)/MR and MR-based radiation therapy planning.
Proxy Mobile IPv6 Extensions for Distributed Mobility Management (2020)

Distributed Mobility Management solutions allow for setting up
networks so that traffic is distributed in an optimal way and does not
rely on centrally deployed anchors to provide IP mobility support.
There are many different approaches to address Distributed Mobility
Management, as for example extending network-based mobility protocols
(like Proxy Mobile IPv6), or client-based mobility protocols (like
Mobile IPv6), among others. This document follows the former approach
and proposes a solution based on Proxy Mobile IPv6 in which mobility
sessions are anchored at the last IP hop router (called mobility
anchor and access router). The mobility anchor and access router is an
enhanced access router which is also able to operate as a local
mobility anchor or mobility access gateway, on a per prefix basis. The
document focuses on the required extensions to effectively support
simultaneously anchoring several flows at different distributed
gateways.
Resilient design in scaled CMOS for energy efficiency (2010)

Traditional processors are designed to guarantee error-free operation under worst-case (1) device & interconnect parameter variations resulting from less than ideal manufacturing process control; (2) static & erratic defects; (3) operating environments such as temperature excursions and voltage droops; (4) critical path activation and path delay degradations due to multiple inputs switching simultaneously in gates containing transistor stacks, or signal coupling from neighboring lines in interconnect paths; (5) speed degradation over the operating lifetime due to transistor aging under voltage, temperature & current stress; (6) early-life failures due to latent defect accelerations; and (7) soft error due to cosmic rays and alpha particle impacts. The voltage-frequency settings for all processors are set based on these infrequently encountered worst-case considerations, even though under typical conditions voltage can be pushed down further or frequency increased without causing errors for most of the processors, thus limiting both energy efficiency and performance in scaled CMOS technologies.
Convenient synthesis of collagen‐related tripeptides for segment condensation (2015)

Chromatography is a common step in the solution-phase synthesis of typical peptides, as well as peptide fragments for subsequent coupling on a solid support. Combining known reagents that form readily separable byproducts is shown to eliminate this step, which wastes time and other resources. Specifically, activating carboxyl groups with isobutyl chloroformate or as pentafluorophenyl esters and using N-methyl morpholine as a base enable chromatography-free synthetic routes in which peptide products are isolated from byproducts by facile evaporation, extraction, and trituration. This methodology was used to access tripeptides related to collagen, such as Fmoc-Pro-Pro-Gly-OH and Fmoc-Pro-Hyp(tBu)-Gly-OH, in a purity suitable for solid-phase segment condensation to form collagen mimetic peptides.