gebhart/patrepeval huggingface dataset:
Beneficial myocardial metabolic effects of insulin during verapamil toxicity in the anesthetized canine (1995)

Verapamil toxicity renders the heart dependent on carbohydrate metabolism. Inasmuch as the positive inotropic effects of all treatments were coincident with increased indices of myocardial carbohydrate uptake, adequate treatment of verapamil toxicity appeared to require maximal myocardial carbohydrate utilization. Hyperinsulinemia-euglycemia allows larger increases in myocardial carbohydrate metabolism and myocardial contractility than calcium chloride, epinephrine, or glucagon, resulting in improved survival rates during severe verapamil toxicity.
Application of F4TCNQ doped spiro-MeOTAD in high performance solid state dye sensitized solar cells (2012)

Amid the investigation of solid-state dye-sensitized solar cells (SDSSCs), it was found that the incorporation of F4TCNQ into the solid hole-transporting materials (HTMs) spiro-MeOTAD forms a spiro-MeOTAD/F4TCNQ (strong electron acceptor) polaron charge-transfer complex. Careful examination indicates that the formation of the polaron charge-transfer complex not only facilitates the conductivity of HTMs but also inhibits the charge recombination across the interface of the heterojunction, i.e. photoanode/HTMs and/or counter electrode/HTMs. As a result, the performance of SDSSCs has been markedly improved by using the organic dye A2-F. At AM1.5 illumination the short circuit current densities J(SC) increase from 8.29 mA cm(-2) (w/o F4TCNQ) to 10.95 mA (w/F4TCNQ), accompanied by a 20% increase of the overall power conversion efficiency, η, from 4.55% to 5.44%.
Enhanced Coercivity in Co-Rich Near-Stoichiometric CoxFe3-xO4+δ Nanoparticles Prepared in Large Batches (2007)

The relationship between the structure and composition with the magnetic properties of near stoichiometric cobalt ferrite nanoparticles CoxFe3-xO4+δ (0.85 < x < 1.1) prepared in large batches with average sizes in the range 60−210 nm has been investigated. Chemical analysis and Rietveld refinement of the X-ray diffraction data in conjunction with Mössbauer spectroscopy allowed us to identify an interplay between particle size, microstructure (concentration of interstitial ions, microstrain, cation arrangement in octahedral and tetrahedral sites), and composition, which sensitively controls the magnetic properties such as coercivity and saturation magnetization. In all cases, cobalt-rich compositions resulted in a higher coercivity, whereas lower degrees of inversion and higher iron contents led to slightly higher saturation magnetization values.
Gain-assisted broadband ring cavity enhanced spectroscopy (2017)

Incoherent broadband cavity enhanced spectroscopy can significantly increase the effective path length of light-matter interaction to detect weak absorption lines over broad spectral range, for instance to detect gases in confined environments. Broadband cavity enhancement can be based on the decay time or the intensity drop technique. Decay time measurement is based on using tunable laser source that is expensive and suffers from long scan time. Intensity dependent measurement is usually reported based on broadband source using Fabry-Perot cavity, enabling short measurement time but suffers from the alignment tolerance of the cavity and the cavity insertion loss. In this work we overcome these challenges by using an alignment-free ring cavity made of an optical fiber loop and a directional coupler, while having a gain medium pumped below the lasing threshold to improve the finesse and reduce the insertion loss. Acetylene (C<sub>2</sub>H<sub>2</sub>) gas absorption is measured around 1535 nm wavelength using a semiconductor optical amplifier (SOA) gain medium. The system is analyzed for different ring resonator forward coupling coefficient and loses, including the 3-cm long gas cell insertion loss and fiber connector losses used in the experimental verification. The experimental results are obtained for a coupler ratio of 90/10 and a fiber length of 4 m. The broadband source is the amplified spontaneous emission of another SOA and the output is measured using a 70pm-resolution optical spectrum analyzer. The absorption depth and the effective interaction length are improved about an order of magnitude compared to the direct absorption of the gas cell. The presented technique provides an engineering method to improve the finesse and, consequently the effective length, while relaxing the technological constraints on the high reflectivity mirrors and free-space cavity alignment.
Sealing Graphene Nanodrums (2019)

Despite theoretical predictions that graphene should be impermeable to all gases, practical experiments on sealed graphene nanodrums show small leak rates. Thus far, the exact mechanism for this permeation has remained unclear, because different potential leakage pathways have not been studied separately. Here, we demonstrate a sealing method that consists of depositing SiO<sub>2</sub> across the edge of suspended multilayer graphene flakes using electron beam-induced deposition. By sealing, leakage along the graphene-SiO<sub>2</sub> interface is blocked, which is observed to result in a reduction in permeation rate by a factor of 10<sup>4</sup>. The experiments thus demonstrate that gas flow along the graphene-SiO<sub>2</sub> interface tends to dominate the leak rate in unsealed graphene nanodrums. Moreover, the presented sealing method enables the study of intrinsic gas leakage through graphene membranes and can enable hermetic graphene membranes for pressure sensing applications.
A comparison of capsazepine and ruthenium red as capsaicin antagonists in the rat isolated urinary bladder and vas deferens (1993)

1. The ability of capsazepine, a recently developed capsaicin receptor antagonist, to prevent the effects of capsaicin on the rat isolated urinary bladder (contraction) and vas deferens (inhibition of electrically-evoked twitches) was compared to that of ruthenium red, a dye which behaves as a functional antagonist of capsaicin. 2. In the rat bladder, capsazepine (3-30 microM) produced a concentration-dependent rightward shift of the curve to capsaicin without any significant depression of the maximal response to the agonist. By contrast, ruthenium red (10-30 microM) produced a non-competitive type of antagonism, characterized by marked depression of the maximal response attainable. Similar findings were obtained in the rat isolated vas deferens in which capsazepine (10 microM) produced a rightward shift of the curve to capsaicin while ruthenium red (3 microM) depressed the maximal response to the agonist. 3. At the concentrations used to block the effect of capsaicin, neither capsazepine nor ruthenium red affected the contractile response of the rat urinary bladder produced by either neurokinin A or electrical field stimulation or the twitch inhibition produced by rat alpha-calcitonin gene-related peptide (alpha CGRP) in the vas deferens. 4. These findings provide additional evidence that both capsazepine and ruthenium red are valuable tools for exploration of the function of capsaicin-sensitive primary afferent neurones. The antagonism of the action of capsaicin by capsazepine is entirely consistent with the proposed interaction of this substance with a vanilloid receptor located on primary afferents, while the action of ruthenium red apparently involves a more complex, non-competitive antagonism.
A Noble‐Metalate Bowl: The Polyoxo‐6‐vanado(V)‐7‐palladate(II) [Pd7V6O24(OH)2]6− (2010)

Nobly born: The bowl-shaped noble metalate [PdII7VV6O24(OH)2]6−(Pd7V6) comprises seven square-planar PdIIO4 units as well as four tetrahedral VVO4 and two square-pyramidal VVO5 addenda units (see picture). The solution stability of Pd7V6 has been demonstrated by 51V NMR spectroscopy, ESI mass spectrometry, and DFT calculations. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Mechanisms underlying volume regulatory decrease by Necturus gallbladder epithelium (1990)

Volume regulatory decrease (VRD) by Necturus gallbladder epithelial cells in Cl Ringer was unaffected by the addition of 5 mM BaCl2 to apical perfusates but was inhibited by the addition of 5 mM BaCl2 and 50 or 3 microM phencyclidine (PCP) to serosal perfusates, suggesting that K channels in the basolateral membrane were activated during VRD. VRD was unaffected by replacement of Cl with NO3 or SCN, suggesting that Cl-dependent Na-K-Cl and K-Cl cotransport were not involved. In SCN Ringer, VRD was inhibited by the addition of 0.1 mM bumetanide to serosal perfusates, suggesting that bumetanide-sensitive anion channels in the basolateral membrane were also activated. A transient 10-mV hyperpolarization of the membrane potential was associated with VRD. The channel blockers that inhibited VRD had little or no effect on the hyperpolarization, suggesting that the changes in membrane potential were unrelated to the changes in cell volume. Perfusion of the apical surface of the epithelium with isotonic solutions containing 10 mM D-glucose resulted in a variable increase in cell volume followed by a variable shrinkage to normal, suggesting that VRD was also activated during organic solute absorption. The increase in cell volume was blocked by the addition of 0.01 or 1 mM phlorizin to mucosal perfusates. The reduction in cell volume was inhibited by the addition of 0.1 mM bumetanide, but not BaCl2 or PCP, to serosal perfusates, indicating the the shrinkage mechanism secondary to glucose addition differed from that seen after exposure to hypotonic perfusates.
ChemInform Abstract: SYNTHESIS AND CHARACTERIZATION OF A HOMOLEPTIC ACTINIDE ALKYL. THE HEPTAMETHYLTHORATE(IV) ION: A COMPLEX WITH SEVEN METAL‐CARBON Σ BONDS (1985)

Abstract Die für Stunden bei Raumtemp. stabile Titelverbindung (I) wird wie aufgezeigt synthetisiert und röntgenanalytisch charakterisiert.
Feasibility of Heart Sounds Measurements from an Accelerometer within an ICD Pulse Generator (2012)

HS, including S3 amplitude and HSTIs, may be measured using PG-embedded circuitry at implant sites without special purpose leads. Further study is warranted to determine if relative changes in heart sounds measurements can be effective in applications such as remote ambulatory monitoring of HF progression and the detection of the onset of HF decompensation.
Self-assembling dendrons as biological mimics to investigate the origins of order and chirality (2002)

Self-assembling dendrons as biological mimics to investigate the origins of order and chirality
Mechanisms of Gadographene-Mediated Proton Spin Relaxation (2013)

Gd(III) associated with carbon nanomaterials relaxes water proton spins at an effectiveness that approaches or exceeds the theoretical limit for a single bound water molecule. These Gd(III)-labeled materials represent a potential breakthrough in sensitivity for Gd(III)-based contrast agents used for magnetic resonance imaging (MRI). However, their mechanism of action remains unclear. A gadographene library encompassing GdCl<sub>3</sub>, two different Gd(III)-complexes, graphene oxide (GO), and graphene suspended by two different surfactants and subjected to varying degrees of sonication was prepared and characterized for their relaxometric properties. Gadographene was found to perform comparably to other Gd(III)-carbon nanomaterials; its longitudinal (<i>r</i><sub>1</sub>) and transverse (<i>r</i><sub>2</sub>) relaxivity is modulated between 12-85 mM<sup>-1</sup>s<sup>-1</sup> and 24-115 mM<sup>-1</sup>s<sup>-1</sup>, respectively, depending on the Gd(III)-carbon backbone combination. The unusually large relaxivity and its variance can be understood under the modified Florence model incorporating the Lipari-Szabo approach. Changes in hydration number (<i>q</i>), water residence time (τ<sub>M</sub>), molecular tumbling rate (τ<sub>R</sub>), and local motion (τ<sub>fast</sub>) sufficiently explain most of the measured relaxivities. Furthermore, results implicated the coupling between graphene and Gd(III) as a minor contributor to proton spin relaxation.
Computational modeling of the rate limiting step in low molecular weight protein tyrosine phosphatase (1999)

Hydrolysis of the phosphoenzyme intermediate is the second and rate limiting step of the reaction catalyzed by the protein tyrosine phosphatases (PTPs). The cysteinyl phosphate thioester bond is cleaved by nucleophilic displacement where an active site water molecule attacks the phosphorus atom. Starting from the crystal structure of the low molecular weight PTP, we study the energetics of this reaction utilizing the empirical valence bond method in combination with molecular dynamics and free energy perturbation simulations. The reactions of the wild-type as well as the D129A and C17S mutants are modeled. For the D129A mutant, which lacks the general acid/base residue Asp-129, an alternative reaction mechanism is proposed. The calculated activation barriers are in all cases in good agreement with experimental reaction rates. The present results together with earlier computational and experimental work now provide a detailed picture of the complete reaction mechanism in many PTPs. The key role played by the structurally invariant signature motif in stabilizing a double negative charge is reflected by its control of the energetics of both transition states and the reaction intermediate.
Interactions in planar metamaterials: from strong coupling to active tuning. (2011)

Abstract not provided.
Development of high-performance ultra large scale 3D processor with high reliability packaging design (2017)

3D-LSI packaging technology with trough silicon via (TSV) is useful for high density and shortened wiring to achieve low power consumption and wide bandwidth for high performance processor. [1] As expected in processor functions, making logic circuit areas larger is required as the scale-up of calculation processing capability, following the trend of many recent core or graphics processing units. By developing 3D-LSI packaging technology compatible with ultra large chips for high-performance processor, and overcoming the issue of yield and reliability, we have achieved a 3D stacked design technology and micro-bump materials of high-yield at product level on a stacked logic processor with almost 700-mm square as the full reticle shot size. In this study, we present the 3D packaging design method to reduce the micro bump stress that originated the underfill material to achieve large size 3D LSI for logic circuit. It was found that the combination of chip organization with a lower stiffness in the stacked structural stability and lower CTE underfill material influenced the vital structure reliability for large chips.
A Selective Toolbox for Nanofabrication (2020)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTA Selective Toolbox for NanofabricationHan-Bo-Ram Lee*Han-Bo-Ram LeeDepartment of Materials Science Engineering, Incheon National University, Incheon, 22012, KoreaMore by Han-Bo-Ram Leehttp://orcid.org/0000-0002-0097-6738 and Stacey F. BentStacey F. BentDepartment of Chemical Engineering, Stanford University, Stanford, California 94305, United StatesMore by Stacey F. Benthttp://orcid.org/0000-0002-1084-5336Cite this: Chem. Mater. 2020, 32, 8, 3323–3324Publication Date (Web):April 14, 2020Publication History Published online14 April 2020Published inissue 28 April 2020https://pubs.acs.org/doi/10.1021/acs.chemmater.0c00838https://doi.org/10.1021/acs.chemmater.0c00838editorialACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2746Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (769 KB) Get e-AlertscloseSUBJECTS:Atomic layer deposition,Chemical vapor deposition,Deposition,Materials,Nanofabrication Get e-Alerts
Supplementary Figure 2 from Effects of HER Family–targeting Tyrosine Kinase Inhibitors on Antibody-dependent Cell-mediated Cytotoxicity in HER2-expressing Breast Cancer (2023)

&lt;p&gt;Flow cytometry control scatter plots for trastuzumab-488 and pertuzumab-550&lt;/p&gt;
Malignant Pheochromocytomas/Paragangliomas and Ectopic Hormonal Secretion: A Case Series and Review of the Literature (2019)

Malignant pheochromocytomas (PCs) and paragangliomas (PGLs) are rare neuroendocrine neoplasms defined by the presence of distant metastases. There is currently a relatively paucity of data regarding the natural history of PCs/PGLs and the optimal approach to their treatment. We retrospectively analyzed the clinical, biochemical, imaging, genetic and histopathological characteristics of fourteen patients with metastatic PCs/PGLs diagnosed over 15 years, along with their response to treatment. Patients were followed-up for a median of six years (range: 1-14 years). Six patients had synchronous metastases and the remaining developed metastases after a median of four years (range 2-10 years). Genetic analysis of seven patients revealed that three harbored succinate dehydrogenase subunit B/D gene (SDHB/D) mutations. Hormonal hypersecretion occurred in 70% of patients; normetanephrine, either alone or with other concomitant hormones, was the most frequent secretory component. Patients were administered multiple first and subsequent treatments including surgery (n = 12), chemotherapy (n = 7), radionuclide therapy (n = 2) and radiopeptides (n = 5). Seven patients had stable disease, four had progressive disease and three died. Ectopic hormonal secretion is rare and commonly encountered in benign PCs. Ectopic secretion of interleukin-6 in one of our patients, prompted a literature review of ectopic hormonal secretion, particularly from metastatic PCs/PGLs. Only four cases of metastatic PC/PGLs with confirmed ectopic secretion of hormones or peptides have been described so far.
Dielectric Torque and Orientation Dynamics of Liquid Crystals with Dielectric Dispersion (2005)

We demonstrate that the finite rate of dielectric relaxation in liquid crystals which has been ignored previously causes profound effects in the fast dielectric reorientation of the director. We propose a theory of dielectric response in which the electric displacement depends not only on the present (as in the standard theory) but also on the past values of electric field and director. We design an experiment with a dual-frequency nematic in which the standard "instantaneous" model and our model predict effects of opposite signs; the experimental data support the latter model.
A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader (2021)

ABSTRACT We describe a generalizable time-resolved Förster resonance energy transfer (TR-FRET)-based platform to profile the cellular action of heterobifunctional degraders (or proteolysis-targeting chimeras; PROTACs), capable of both accurately quantifying protein levels in whole cell lysates in less than 1 h and measuring small-molecule target engagement to en-dogenous proteins, here specifically for human bromodomain-containing protein 4 (BRD4). The detection mix consists of a single primary antibody targeting the protein of interest, a luminescent donor-labeled anti-species nanobody, and a fluorescent acceptor ligand. Importantly, our strategy can readily be applied to other targets of interest and will greatly facilitate the cell-based profiling of small molecule inhibitors and PROTACs in high-throughput format with unmodified cell lines. We further-more validate our platform in the characterization of celastrol, a p -quinone methide-containing pentacyclic triterpenoid, as a broad cysteine-targeting E3 ubiquitin ligase warhead for potent and efficient targeted protein degradation.
B4GALT1 Is a New Candidate to Maintain the Stemness of Lung Cancer Stem Cells (2019)

Combined transcriptomic and chromatin accessibility study of 3D vs. 2D LUAD cultures led to the identification of B4GALT1 as a new factor involved in the propagation and maintenance of LUAD CSCs.
Selective Mitogen Activated Protein Kinase Activity Sensors through the Application of Directionally Programmable D Domain Motifs (2014)

Accurate and quantitative methods for measuring the dynamic fluctuations of protein kinase activities are critically needed as diagnostic tools and for the evaluation of kinase-targeted inhibitors, which represent a major therapeutic development area in the treatment of cancer and other diseases. In particular, rapid and economical methods that utilize simple instrumentation and provide quantitative data in a high throughput format will have the most impact on basic research in systems biology and medicine. There are over 500 protein kinases in the human kinome. Among these, the mitogen activated protein (MAP) kinases are recognized to be central players in key cellular signaling events and are associated with essential processes including growth, proliferation, differentiation, migration, and apoptosis. The major challenge with MAP kinase sensor development is achieving high selectivity since these kinases rely acutely on secondary interactions distal to the phosphorylation site to impart substrate specificity. Herein we describe the development and application of selective sensors for three MAP kinase subfamilies, ERK1/2, p38α/β, and JNK1/2/3. The new sensors are based on a modular design, which includes a sensing element that exploits a sulfonamido-oxine (Sox) fluorophore for reporting phosphorylation, a recognition and specificity element based on reported docking domain motifs and a variable linker, which can be engineered to optimize the intermodule distance and relative orientation. Following rigorous validation, the capabilities of the new sensors are exemplified through the quantitative analysis of the target MAP kinases in breast cancer progression in a cell culture model, which reveals a strong correlation between p38α/β activity and increased tumorgenicity.