gebhart/patrepeval huggingface dataset:
Implementation of a discrete Legendre adaptive IIR filter using the DSP56001 (2002)

This paper presents the results of an implementation of a discrete Legendre adaptive IIR filter using the Motorola DSP56001 processor. The impulse response of the adaptive filter is a linear combination of orthogonal sequences. The filter is attractive because a long-duration impulse response can be realized with fewer taps than an FIR filter, with the additional advantage that the simple and well-known LMS algorithm, can be used to update the weights. The paper discusses some practical issues related to the implementation of the filter on the fixed-point DSP56001 processor in an adaptive line enhancer configuration.
Diversification of Autonomous Vehicle Driving Behavior (2017)

Driver behavioral analysis can be described as the process of analyzing sensor data collected from a vehicle to identify unique facets of the manner the vehicle handles while under the control of a driver. This analysis can be used to either uniquely identify a driver or differentiate him/her from other drivers. Driver behavioral analysis has practical applications in insurance, safety and security. Autonomous vehicle controllers are software systems that are static by nature. This implies that while driver behavior analysis can be carried out on autonomous vehicles, the unique driving patterns that can be used to differentiate human drivers will not be possible with autonomous vehicles controlled by the same agent. This scenario is undesirable from a security viewpoint. It is widely accepted that the predictability of software systems makes them vulnerable, this is more so if a large of number of users utilize the software system. Based on the above, in this paper, we argue for the necessity of creating diversity in the driving behavior of autonomous vehicles. We present a conceptual framework that lays out how this can be accomplished at low cost, with high flexibility and without compromising one of the major advantages of autonomous vehicles - safety. Using the example of a remote vehicle hijack, an attack scenario that has shown to be practical in recent times, we highlight an application of our proposed model. We show how having diverse behavior is advantageous in creating a fail-safe remote vehicle hijack detection system.
Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction (2006)

A strong association between weight loss induced by dietary CHO restriction and variability in genes regulating fat digestion, hepatic glucose metabolism, intravascular lipoprotein remodeling, and appetite were detected. These discoveries could provide clues to important physiologic adaptations underlying the body mass response to CHO restriction.
Synthesis of Dianhydrohexitole-based Benzamidines as Factor Xa Inhibitors Using Cross Couplings, Phenyl Ether and Amidine Formations as Key Steps (2003)

Starting with isosorbide or isomannide several dianhydrohexitole-based benzamidines were synthesized as potential factor Xa inhibitors. The key steps for the synthesis of the bisbenzamidines were nucleophilic aromatic substitutions and Mitsunobu reactions to build up phenylethers. Another type of monobenzamidines had ortho-substituted biphenyl groups. Their synthesis necessitated an optimization of cross coupling procedures due to the great sterical hindrance of the ortho-substituent. The benz­amidines showed biological activity against factor Xa and selectivity against other serine proteases.
Two-year clinical effectiveness of a resin-modified glass-ionomer adhesive. (2003)

A 100% retention rate was recorded after 2 years of clinical service. However, only 15% of the restorations showed a perfect marginal adaptation. All marginal defects were small, either located at the incisal or at the cervical margin. The percentage of small marginal defects was obviously higher at the incisal enamel margin than at the cervical dentin margin. At the 2-year recall, half of the restorations exhibited a superficial, localized discoloration at the restoration margin, however none of the restorations showed deep, generalized discoloration. Remaining criteria of clinical effectiveness were rated as excellent.
Abstract 20013: Adiponectin Protects Against Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice (2014)

Introduction & Objective: Human population-based studies have found an independent association of obesity or visceral adiposity with abdominal aortic aneurysms (AAA) presence or increasing abdominal aortic diameter. However, the molecular mechanisms that link obesity to AAA development remain largely unknown. The unbalanced production of adipokines by dysfunctional adipose tissue in obese individuals greatly contributes to the increased cardiovascular risk associated with obesity. In this study we assessed the role of adiponectin, an anti-inflammatory adipokine typically down-regulated in obese individuals, in a model of AAA using apolipoprotein E/adiponectin double-knockout (ApoE-/- Apn-/-) mice. Methods & Results: We used an experimental model where angiotensin II (Ang II) is infused to hyperlipidemic ApoE-deficient mice for 28 days via a subcutaneous osmotic mini-pump to induce the formation of supra-renal AAA. We found that Ang II infusion for 7 days leads to a significant decrease in the expression of adiponectin in white adipose tissue in this model. Ang II infusion in male ApoE-/- Apn-/- mice led to a higher incidence of AAA and an increase in the maximal supra-renal aortic diameter compared with that of ApoE-/- mice as determined by ultrasound imaging (incidence of AAA: 100% vs. 42%, maximal aortic diameter: 2.12 ± 0.07 mm vs. 1.67 ± 0.09 mm, respectively at 28 days). Adiponectin deficiency augmented the early accumulation of macrophages into the aortic wall in Ang II-infused mice. Gene expression of the pro-inflammatory factors (TNFa, IL-1b, IL-6 and CCL2/MCP-1) was significantly increased in the supra-renal aorta of ApoE-/- Apn-/- relative to ApoE-/- mice after Ang II infusion. MMP-2 and MMP-9 activation was also augmented in the aorta of ApoE-/- Apn-/- mice compared to ApoE-/- mice. Conclusions: These results suggest that adiponectin exerts anti-inflammatory actions in the aortic wall that may protect against Ang II-induced AAA formation and growth in hyperlipidemic ApoE-deficient mice. Since adiponectin expression is significantly decreased in obese individuals, these results provide a potential mechanistic connection between obesity and AAA development.
The Heilbronn Laparoscopic Training Program for Laparoscopic Suturing: Concept and Validation (2005)

No AccessJournal of UrologyUrological Survey: Urolithiasis/Endourology: Urolithiasis, Endourology and Laparoscopy1 Nov 2005The Heilbronn Laparoscopic Training Program for Laparoscopic Suturing: Concept and Validation Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)68808-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "The Heilbronn Laparoscopic Training Program for Laparoscopic Suturing: Concept and Validation." The Journal of Urology, 174(5), p. 1848 © 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 174Issue 5November 2005Page: 1848 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement Loading ...
PL‐05‐01: Understanding and targeting diverse conformations of aggregated proteins that trigger neurodegeneration (2012)

Abstract not available.
Naphthothiophenes. 4. Preparation of multisubstituted 4-naphtho[2,1-b]thiophenemethanols and the effect of side chain modification on antimalarial activity of 8-trifluoromethyl-4-naphtho[2,1-b] thiophenemethanols (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNaphthothiophenes. 4. Preparation of multisubstituted 4-naphtho[2,1-b]thiophenemethanols and the effect of side chain modification on antimalarial activity of 8-trifluoromethyl-4-naphtho[2,1-b] thiophenemethanolsBijan P. Das, Merrill E. Nuss, and David W. Boykin Jr.Cite this: J. Med. Chem. 1974, 17, 5, 516–519Publication Date (Print):May 1, 1974Publication History Published online1 May 2002Published inissue 1 May 1974https://pubs.acs.org/doi/10.1021/jm00251a009https://doi.org/10.1021/jm00251a009research-articleACS PublicationsRequest reuse permissionsArticle Views50Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of a Near-Wall Turbulence Model and Applicarion to Jet Impingement Heat Transfer (2000)

A near-wall turbulence model was developed and applied to heat and fluid flows for an impinging jet flow. The k‐e‐fl model was modified for predictions in strongly strained turbulent flows. To derive a realizable eddy viscosity, the fl2 function was newly formulated. The near-wall eAect and the anisotropic production were reflected in the e-equation. The model performance was validated by the relevant experimental data. The predicted results were compared with those by the k‐e model and by the k‐e‐v 2 model. The application to jet impingement heat transfer revealed that the present numerical predictions of wall heat transfer show good agreement with the experimental data in the stagnation region. The influence of the Reynolds number on the stagnation Nusselt number was investigated. The model performance was shown to be generally satisfactory. ” 2001 Elsevier Science Inc. All rights reserved.
Estrogen receptor β selective nonsteroidal estrogens: seeking clinical indications (2010)

Subtype selective ERbeta agonist therapy seems very promising. However, more clinical testing is needed to firmly establish its therapeutic potential. At this point, ERbeta is a promising target in search of an indication.
Energy distribution of electron flux at electrodes in a low pressure capacitively coupled plasma (2013)

A one-dimensional particle-in-cell (PIC) model is used to examine the energy distribution of electron flux at electrodes [labeled ge(ε,t), where ε is energy and t is time] in a low pressure 60 MHz capacitively coupled Ar discharge. The effect of gas pressure and an auxiliary DC voltage on ge(ε,t) is also investigated. It is found that the electrons only leave the plasma for a short time period during the radio-frequency (RF) cycle when the sheath collapses at the electrode. Furthermore, majority of the exiting electrons have energies below 10 eV with a distribution ge(ε,t) that is narrow in both energy and time. At relatively high pressures (≥4.67 Pa for the conditions considered), the relationship between the time-average distribution ge(ε) and electron temperature in the plasma (Te) can be easily established. Below 4.67 Pa, kinetic effects become important, making it difficult to interpret ge(ε) in terms of Te. At low pressures, ge(ε,t) is found to broaden in both energy and time except for a narrow pressure range around 1.2 Pa where the distribution narrows temporally. These low pressure kinetic phenomena are observed when the electrons can be accelerated by expanding sheaths to speeds that allow them to traverse the inter-electrode distance quickly (&amp;lt;1.5 RF cycles for conditions considered) and when electrons undergo few collisions during this excursion. The mean energy of exiting electrons increases with decreasing gas pressure, especially below 1.0 Pa, due to higher Te and secondary electrons retaining a larger fraction of the energy they gained during initial sheath acceleration. For the relatively small DC voltages examined (|Vdc|/Vrf ≤ 0.15), the application of a negative DC voltage on an electrode decreases the electron flux there but has a weak impact on the ge profile.
Staufen blocks autophagy in neurodegeneration (2019)

Abstract Objective The mechanistic target of rapamycin (mTOR) kinase is one of the master coordinators of cellular stress responses, regulating metabolism, autophagy, and apoptosis. We recently reported that Staufen1 (STAU1), a stress granule (SG) protein, was overabundant in fibroblast cell lines from patients with spinocerebellar ataxia type 2 (SCA2), amyotrophic lateral sclerosis, frontotemporal degeneration, Huntington’s, Alzheimer’s, and Parkinson’s diseases as well as animal models, and patient tissues. STAU1 overabundance is associated with mTOR hyperactivation and links SG formation with autophagy. Our objective was to determine the mechanism of mTOR regulation by STAU1. Methods We determined STAU1 abundance with disease- and chemical-induced cellular stressors in patient cells and animal models. We also used RNA binding assays to contextualize STAU1 interaction with MTOR mRNA. Results STAU1 and mTOR were overabundant in BAC- C9orf72, ATXN2 Q127 , and Thy1 -TDP-43 transgenic mouse models. Reducing STAU1 levels in these mice normalized mTOR levels and activity and autophagy-related marker proteins. We also saw increased STAU1 levels in HEK293 cells transfected to express C9orf72-relevant dipeptide repeats (DPRs). Conversely, DPR accumulations were not observed in cells treated by STAU1 RNAi. Overexpression of STAU1 in HEK293 cells increased mTOR levels through direct MTOR mRNA interaction, activating downstream targets and impairing autophagic flux. Targeting mTOR by rapamycin or RNAi normalized STAU1 abundance in a SCA2 cellular model. Interpretation STAU1 interaction with mTOR drives its hyperactivation and inhibits autophagic flux in multiple models of neurodegeneration. Staufen, therefore, constitutes a novel target to modulate mTOR activity, autophagy, and for the treatment of neurodegenerative diseases.
Baseline circulating soluble factors as predictors of immune-related adverse events (irAEs) in patients (pts) with metastatic clear cell renal carcinoma (mRCC) treated with nivolumab: A translational NIVOREN GETUG-AFU 26 study. (2023)

724 Background: The NIVOREN GETUG-AFU 26 study launched a translational research program to quantify baseline circulating soluble factors levels and correlate them with outcomes and irAEs in mRCC pts treated with nivolumab. We previously identified (training-set = 80 pts, validation-set= 233 pts) several soluble factors associated with overall survival (IL-6, IL-8, VEGF, BAFF, and CXCL13) (Carril-Ajuria et al. ASCO. 2022). Our aim was to evaluate the association between baseline levels of circulating soluble factors and the presence of all grade and severe irAEs. Methods: 720 patients treated with nivolumab within the NIVOREN study and with available safety data were included in the study. The association between baseline levels of seven different circulating soluble factors (VEGF, VCAM-1, IL-6, IL-7, IL-8, BAFF, CXCL13) and the development of all grade and severe irAEs was evaluated in those pts who had previously undergone soluble factors quantification within the translational program. The association between other systemic inflammatory markers (the lung immune prognostic index (LIPI), LDH and the derived neutrophil to lymphocyte ratio (dNLR)) and irAEs was also evaluated. Results: Out of 720 pts, 456 (63%) and 143 (20%) pts presented all grade and severe irAEs respectively. Soluble factors quantification at baseline was available for 353 pts. Baseline characteristics were similar to the overall trial population. Lower levels of circulating IL-6 (cut-off: 8.7 pg/ml) at baseline were significantly associated with a higher risk of all grade irAEs (p=0.025). Lower dNLR levels (&lt;3, p=0.003) at baseline and a good LIPI score (p=0.014) were also associated with a higher risk of all grade AEs. No other significant associations were found between circulating soluble factors and all grade irAEs. No significant associations were found between circulating solubles factors/systemic inflammatory markers and the presence of severe irAEs Conclusions: Using the cut-off values previously identified, we observed that lower baseline levels of circulating IL-6 were associated with an increased risk of all grade irAEs. Good LIPI patients and those with a lower dNLR also presented a higher risk of all grade irAEs. Baseline circulating soluble factors and systemic inflammatory markers failed to demonstrate a significant association with the development of severe irAEs.
Clinical images - a quarterly column: subacute combined degeneration of the spinal cord. (2013)

Subacute combined degeneration (SCD) of the spinal cord is a treatable and potentially reversible myelopathy that primarily affects the dorsal and lateral columns. Its causes directly and indirectly involve vitamin B12 deficiency, and symptoms range from mild paresthesias to paraplegia and incontinence.
Concealment-Aware Motion Estimation and Mode Selection for Error Resilient Video Coding (2006)

This paper proposes a new concealment-aware motion estimation and mode selection scheme for error resilient video coding, where a new distortion metric is adopted to better accounts for the impact of "worst-case" distortion on the overall perceptual video quality than the existing statistically defined end-to-end distortion metric does. Effective "motion copy" error concealment is assumed at the decoder. The proposed scheme requires no end-to-end distortion estimation, and thus, achieves low complexity. Simulation result with an H.264 codec shows that our proposed scheme improves subjective decoder reconstructed video quality, especially for sequences of medium motion.
A general framework for combining diagrammatic and symbolic problem solving (2006)

We introduce Vivid, a domain-independent framework for heterogeneous natural deduction that combines diagrammatic and symbolic reasoning. The framework is presented in the form of a family of denotational proof languages (DPLs). Diagrams are represented as possibly partial descriptions of finite system states. This allows us to deal with incomplete information, which we formalize by admitting sets as attribute values. We introduce a notion of attribute interpretations that enables us to interpret first-order signatures into such system states, and develop a formal semantic framework based on Kleene’s strong three-valued logic. We extend the assumption-base semantics of DPLs to accommodate diagrammatic reasoning by introducing general inference mechanisms for the valid extraction of information from diagrams and for the incorporation of sentential information into diagrams. A rigorous big-step operational semantics is given, on the basis of which we prove that our framework is sound, and an example of a particular instance of Vivid is discussed in detail.
Genome-wide methylation profiling identifies hypermethylated biomarkers in high-grade cervical intraepithelial neoplasia (2012)

Epigenetic modifications, such as aberrant DNA promoter methylation, are frequently observed in cervical cancer. Identification of hypermethylated regions allowing discrimination between normal cervical epithelium and high-grade cervical intraepithelial neoplasia (CIN2/3), or worse, may improve current cervical cancer population-based screening programs. In this study, the DNA methylome of high-grade CIN lesions was studied using genome-wide DNA methylation screening to identify potential biomarkers for early diagnosis of cervical neoplasia. Methylated DNA Immunoprecipitation (MeDIP) combined with DNA microarray was used to compare DNA methylation profiles of epithelial cells derived from high-grade CIN lesions with normal cervical epithelium. Hypermethylated differentially methylated regions (DMRs) were identified. Validation of nine selected DMRs using BSP and MSP in cervical tissue revealed methylation in 63.2-94.7% high-grade CIN and in 59.3-100% cervical carcinomas. QMSP for the two most significant high-grade CIN-specific methylation markers was conducted exploring test performance in a large series of cervical scrapings. Frequency and relative level of methylation were significantly different between normal and cancer samples. Clinical validation of both markers in cervical scrapings from patients with an abnormal cervical smear confirmed that frequency and relative level of methylation were related with increasing severity of the underlying CIN lesion and that ROC analysis was discriminative. These markers represent the COL25A1 and KATNAL2 and their observed increased methylation upon progression could intimate the regulatory role in carcinogenesis. In conclusion, our newly identified hypermethylated DMRs represent specific DNA methylation patterns in high-grade CIN lesions and are candidate biomarkers for early detection.
Engaging Industry in Empirical Research (2008)

Background: Companies can only capitalise on research that is relevant to their problems, usable in practice and brought to their attention. Such high value research almost always requires academic and industrial collaboration. Problem: Many academic information systems and software engineering researchers struggle to engage industry in their research. Aim: To investigate the gap between academic research and industry participation in information systems and software engineering. Method: An analysis of UK and Australian Research Council funded information systems-related projects in which companies and academics are currently collaborating. Outcomes: Only 20-30% of research council funded information systems-related projects have industry collaborators. Many collaborators in research projects are in the public sector and have been involved with research previously. Impact: Our results can contribute to increased industrial collaboration in research projects by helping researchers to identify projects most attractive to industrial collaborators and to target companies most likely to agree to participate in research projects.
Amphiphilic Molecular Design as a Rational Strategy for Tailoring Bicontinuous Electron Donor and Acceptor Arrays: Photoconductive Liquid Crystalline Oligothiophene−C60 Dyads (2008)

For tailoring solution-processable optoelectronic thin films, a rational strategy with amphiphilic molecular design is proposed. A donor-acceptor dyad consisting of an oligothiophene and C60, when modified with a hydrophilic wedge on one side and a paraffinic wedge on the other (1Amphi), forms over a wide temperature range a photoconducting smectic A liquid crystal having bicontinuous arrays of densely packed donor and acceptor units. In contrast, when modified with only paraffinic wedges (1Lipo), the dyad forms a smectic A liquid crystalline mesophase, which however is poorly conductive. As indicated by an absorption spectral feature along with a synchrotron radiation small-angle X-ray scattering profile, 1Lipo in the lamellar structure does not adopt a uniform head/tail orientation. Such defective donor and acceptor arrays likely contain a large number of trapping sites, leading to short-lived charge carriers, as observed by a flash photolysis time-resolved microwave conductivity study.