gebhart/patrepeval huggingface dataset:
Design Patterns for Object-Oriented Software Development (1994)

Provides an overview of state-of-the-art approaches in object-oriented technology as well as practical guidance for their use in software design. Covers forming class hierarchies and interaction relationships between objects, software architectures that allow for reuse of code and design, and documenting object-oriented design on an adequate abstraction level. Includes examples and a case study.
Supplementary Table 1 from Single Nucleotide Polymorphism–Based Genome-Wide Chromosome Copy Change, Loss of Heterozygosity, and Aneuploidy in Barrett's Esophagus Neoplastic Progression (2023)

Supplementary Table 1 from Single Nucleotide Polymorphism–Based Genome-Wide Chromosome Copy Change, Loss of Heterozygosity, and Aneuploidy in Barrett's Esophagus Neoplastic Progression
Estimation of the spatial distribution of traps using space-charge-limited current measurements in an organic single crystal (2012)

We used a mobility edge transport model and solved the drift-diffusion equation to characterize the space-charge-limited current of a rubrene single-crystal hole-only diode. The current-voltage characteristics suggest that current is injection-limited at high voltage when holes are injected from the bottom contact (reverse bias). In contrast, the low-voltage regime shows that the current is higher when holes are injected from the bottom contact as compared to hole injection from the top contact (forward bias), which does not exhibit injection-limited current in the measured voltage range. This behavior is attributed to an asymmetric distribution of trap states in the semiconductor, specifically, a distribution of traps located near the top contact. Accounting for a localized trap distribution near the contact allows us to reproduce the temperature-dependent current-voltage characteristics in forward and reverse bias simultaneously, i.e., with a single set of model parameters. We estimated that the local trap distribution contains $1.19\ifmmode\times\else\texttimes\fi{}{10}^{11}$ cm${}^{\ensuremath{-}2}$ states and decays as $\mathrm{exp}\phantom{\rule{0.16em}{0ex}}(\ensuremath{-}x/32.3\phantom{\rule{4.pt}{0ex}}\text{nm})$ away from the semiconductor-contact interface. The local trap distribution near one contact mainly affects injection from the same contact, hence breaking the symmetry in the charge transport. The model also provides information of the band mobility, energy barrier at the contacts, and bulk trap distribution with their corresponding confidence intervals.
Pancreatic endocrine‐like cells differentiated from human umbilical cords Wharton’s jelly mesenchymal stem cells using small molecules (2018)

Following success of pancreatic islet transplantation in the treatment of Type I diabetes mellitus, there is a growing interest in using cell-based treatment approaches. However, severe shortage of donor islets-pancreas impeded the growth, and made researchers to search for an alternative treatment approaches. In this context, recently, stem cell-based therapy has gained more attention. The current study demonstrated that epigenetic modification improves the in vitro differentiation of Wharton's jelly mesenchymal stem cells (WJMSCs) into pancreatic endocrine-like cells. Here we used two histone deacetylase (HDAC) inhibitors namely trichostatin A (TSA) and TMP269. TSA inhibits both class I and II HDACs whereas TMP269 inhibits only class IIa HDACs. WJMSCs were differentiated using a multistep protocol in a serum-free condition with or without TSA pretreatment. A marginal improvement in differentiation was observed after TSA pretreatment though it was not significant. However, exposing endocrine precursor-like cells derived from WJMSCs to TMP269 alone has significantly improved the differentiation toward insulin-producing cells. Further, increase in the expression of paired box 4 (PAX4), insulin, somatostatin, glucose transporter 2 (GLUT2), MAF bZIP transcription factor A (MAFA), pancreatic duodenal homeobox 1 (PDX-1), and NKX6.1 was observed both at messenger RNA and protein levels. Nevertheless, TMP269-treated cells secreted higher insulin upon glucose challenge, and demonstrated increased dithizone staining. These findings suggest that TMP269 may improve the in vitro differentiation of WJMSCs into insulin-producing cells.
IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition (2014)

Mutations of IDH1 and IDH2, which produce the oncometabolite 2-hydroxyglutarate (2HG), have been identified in several tumors, including acute myeloid leukemia. Recent studies have shown that expression of the IDH mutant enzymes results in high levels of 2HG and a block in cellular differentiation that can be reversed with IDH mutant-specific small-molecule inhibitors. To further understand the role of IDH mutations in cancer, we conducted mechanistic studies in the TF-1 IDH2 R140Q erythroleukemia model system and found that IDH2 mutant expression caused both histone and genomic DNA methylation changes that can be reversed when IDH2 mutant activity is inhibited. Specifically, histone hypermethylation is rapidly reversed within days, whereas reversal of DNA hypermethylation proceeds in a progressive manner over the course of weeks. We identified several gene signatures implicated in tumorigenesis of leukemia and lymphoma, indicating a selective modulation of relevant cancer genes by IDH mutations. As methylation of DNA and histones is closely linked to mRNA expression and differentiation, these results indicate that IDH2 mutant inhibition may function as a cancer therapy via histone and DNA demethylation at genes involved in differentiation and tumorigenesis.
A Hypervalent Iodine-Induced Double Annulation Enables a Concise Synthesis of the Pentacyclic Core Structure of the Cortistatins (2009)

A stereocontrolled synthesis of a complex pentacycle embodying the molecular architecture of the cortistatin class of natural products was achieved from the (+)-Hajos-Parrish ketone. The cornerstone of our approach is a hypervalent iodine induced tandem intramolecular oxidative dearomatization and nitrile oxide cycloaddition. The manner in which these ring formations were orchestrated has yielded a rather concise strategy for synthesis.
Actions Speak Louder Than (Pass)words: Passive Authentication of\n Smartphone Users via Deep Temporal Features (2019)

Prevailing user authentication schemes on smartphones rely on explicit user\ninteraction, where a user types in a passcode or presents a biometric cue such\nas face, fingerprint, or iris. In addition to being cumbersome and obtrusive to\nthe users, such authentication mechanisms pose security and privacy concerns.\nPassive authentication systems can tackle these challenges by frequently and\nunobtrusively monitoring the user's interaction with the device. In this paper,\nwe propose a Siamese Long Short-Term Memory network architecture for passive\nauthentication, where users can be verified without requiring any explicit\nauthentication step. We acquired a dataset comprising of measurements from 30\nsmartphone sensor modalities for 37 users. We evaluate our approach on 8\ndominant modalities, namely, keystroke dynamics, GPS location, accelerometer,\ngyroscope, magnetometer, linear accelerometer, gravity, and rotation sensors.\nExperimental results find that, within 3 seconds, a genuine user can be\ncorrectly verified 97.15% of the time at a false accept rate of 0.1%.\n
Crystal and molecular structure of an unusual salt formed from the radical cation of tetrathiafulvalene (TTF) and the trichloromercurate anion (HgCl3), (TTF)(HgCl3) (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal and molecular structure of an unusual salt formed from the radical cation of tetrathiafulvalene (TTF) and the trichloromercurate anion (HgCl3), (TTF)(HgCl3)T. J. Kistenmacher, M. Rossi, C. C. Chiang, R. P. Van Duyne, and A. R. SiedleCite this: Inorg. Chem. 1980, 19, 12, 3604–3608Publication Date (Print):December 1, 1980Publication History Published online1 May 2002Published inissue 1 December 1980https://pubs.acs.org/doi/10.1021/ic50214a009https://doi.org/10.1021/ic50214a009research-articleACS PublicationsRequest reuse permissionsArticle Views96Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad antibody responses in humans, a RAYS-based analysis (2011)

Antibody responses to tumor antigens play an important role in initiating a cellular antitumor response with respect to antigen cross-presentation and T cell cross-priming. Successful vaccination strategies rely on an optimally timed activation of the humoral and cellular immune system by using appropriate adjuvant stimulation. The LUD99-008 trial used the cancer testis antigen NY-ESO-1 formulated with ISCOMATRIX adjuvant injected into patients intramuscularly. It was shown that this vaccination strategy is a safe and highly potent activator of the humoral and cellular immune system. Using the RAYS technology, we analyzed in detail the humoral immune response in these patients before and after vaccination: during the course of repeated vaccinations with the adjuvant, antibody titers against NY-ESO-1 and cross-reactivity to LAGE 1A and B increased as an indicator of an enhanced immune response, whereas no antibody response could be detected after vaccination without the adjuvant. Analysis of single fragments of the NY-ESO-1 protein revealed that the humoral response was almost exclusively directed against the N-terminal fragments and the number of fragments and their length being recognized by the NY-ESO-1-specific antibodies increased during the course of vaccination. The humoral immune response mainly consisted of antibodies of the IgG1 and IgG3 subclass. We rarely found IgG2 and IgG4 subclass antibodies. Our results support the implication that target-specific antibodies raised after vaccination contribute to the stimulation of an effective T cell response against the target antigen.
ChemInform Abstract: Singlet Oxygen Production from Fullerene Derivatives: Effect of Sequential Functionalization of the Fullerene Core. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Charge Transfer during the Dissociation of H2 and the Charge State of H Atoms in Liquid Gallium (2019)

Ab initio calculations have been performed on the liquid gallium–hydrogen system at 100 °C. Gallium was found to interact with both free hydrogen atoms and H2, transferring charge in the process. First-principles computer modeling showed that the dissociation of H2 is a consequence of charge transfer in liquid gallium–hydrogen systems, even at low temperature. Once negatively charged, hydrogen atoms interact with each other and are stabilized by positively charged gallium atoms inducing local atomic arrangements analogous to parts of the digallane molecule.
Age Estimation of a Hybrid Energy Storage System for Vehicular Start–Stop (2023)

Ultracapacitors are energy storage devices that have shown outstanding capability in a vast spectrum of applications, mainly in energy storage systems required to deliver short bursts of electrical energy. Ultracapacitors possess high power density while batteries possess high energy density. In this paper, a hybrid energy storage device comprising a lithium-ion ultracapacitor module and a lead acid battery was modeled, built, and tested for vehicular start–stop application, which requires a much larger number of engine cranking events than conventional vehicles. The combination of a lead acid battery with Li-ion ultracapacitors was chosen due to the fact that the vast majority of vehicles utilize lead acid batteries to crank the internal combustion engine. This allows retrofitting this hybrid setup in conventional vehicles along with the start–stop feature without inflicting damage to the already installed lead acid battery. The start–stop feature puts high stress on the lead acid battery, contributing to its faster aging. This feature is commonly found in hybrid vehicles to save the unnecessarily burned fuel during idling. This paper discusses aging of the lead acid battery as a result of being used in hybrid vehicles equipped with start–stop when used alone versus when used in the hybrid setup. The paper shows cranking tests performed on a number of cars to obtain voltage, current, power, and energy requirements for combustion engine cranking. Mathematical derivation, analysis, and an energy storage age estimation method are also presented. A set of cranking events followed by capacity checks performed on two automobile energy storage systems, one being a lead acid battery alone and the other being the proposed hybrid module, show the advantage of integrating the ultracapacitor module with the lead acid battery to extend its life span almost fivefold in a hybrid automobile.
Phase 1/2 multiple ascending dose trial of the prostate-specific membrane antigen-targeted antibody drug conjugate MLN2704 in metastatic castration-resistant prostate cancer (2020)

This phase 1/2 study evaluated the dose-limiting toxicity and maximum tolerated dose of MLN2704, a humanized monoclonal antibody MLN591 targeting prostate-specific membrane antigen, linked to the maytansinoid DM1 in patients with progressive metastatic castration-resistant prostate cancer.
ChemInform Abstract: Biosynthesis of Porphyrins and Related Macrocycles. Part 53. Stereochemical Studies on the Enzymic Formation of Hydroxymethylbilane, the Precursor of Uroporphyrinogen III. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
[Prospective study of iliac extraction of the kidney after laparoscopic nephrectomy]. (2005)

Radical nephrectomy or living donor kidney harvesting can be performed via laparoscopy with extraction of the operative specimen via a low iliac incision. This incision ensures extraction of very large specimens while preserving the aesthetic and functional advantages of laparoscopy with no increased cancer risk. They are simple to perform and easily reproducible via a transperitoneal or retroperitoneal approach. Absence of muscle section maintains the integrity of the abdominal wall. No postoperative incisional hernia has been observed.
Preferential cytoplasmic localization of p34cdc2 in recurrent human squamous cell carcinoma after radiotherapy. (1997)

Duration of the G2-phase delay and arrest after exposure to ionizing radiation is thought to influence radiosensitivity. The kinase activity of the p34cdc2-cyclin B complex and the p34cdc2-cyclin A complex is implicated in G2- to M-phase transition and in G2-phase arrest after exposure to ionizing radiation. We analyzed the expression level and the subcellular location of p34cdc2, cyclin A and cyclin B in head and neck squamous cell carcinoma (SCC) tumors; samples were obtained from patients with locally nonrecurrent and recurrent tumors that had been treated by surgery and radiotherapy. No significant difference was noticed in cyclin A, cyclin B and p34cdc2 expression. However, we noted a significant preferential cytoplasmic location of p34cdc2 in recurring tumors compared to the nonrecurring ones (P < 0.001). This abnormal location of p34cdc2 occurs even in primary tumors in patients with recurring tumors, suggesting that a default in the activation of p34cdc2 kinase could be implicated in clinical radioresistance.
Nuclear Reprogramming: Kinetics of Cell Cycle and Metabolic Progression as Determinants of Success (2012)

Establishment of totipotency after somatic cell nuclear transfer (NT) requires not only reprogramming of gene expression, but also conversion of the cell cycle from quiescence to the precisely timed sequence of embryonic cleavage. Inadequate adaptation of the somatic nucleus to the embryonic cell cycle regime may lay the foundation for NT embryo failure and their reported lower cell counts. We combined bright field and fluorescence imaging of histone H(2b)-GFP expressing mouse embryos, to record cell divisions up to the blastocyst stage. This allowed us to quantitatively analyze cleavage kinetics of cloned embryos and revealed an extended and inconstant duration of the second and third cell cycles compared to fertilized controls generated by intracytoplasmic sperm injection (ICSI). Compared to fertilized embryos, slow and fast cleaving NT embryos presented similar rates of errors in M phase, but were considerably less tolerant to mitotic errors and underwent cleavage arrest. Although NT embryos vary substantially in their speed of cell cycle progression, transcriptome analysis did not detect systematic differences between fast and slow NT embryos. Profiling of amino acid turnover during pre-implantation development revealed that NT embryos consume lower amounts of amino acids, in particular arginine, than fertilized embryos until morula stage. An increased arginine supplementation enhanced development to blastocyst and increased embryo cell numbers. We conclude that a cell cycle delay, which is independent of pluripotency marker reactivation, and metabolic restraints reduce cell counts of NT embryos and impede their development.
Interleukin-5, Eosinophilic Diseases and Therapeutic Intervention (2003)

Interleukin 5 (IL-5) is the key cytokine in an eosinophil's life span: it supports eosinophilopoiesis and eosinophil differentiation, contributes to eosinophil migration, tissue localisation and function, and prevents eosinophil apoptosis. Given the likely role of eosinophils in chronic inflammatory diseases, a lot of research over the past decade was aimed at antagonising IL-5 function. It appears from recent studies that, although this can easily be achieved in vitro, blocking IL-5 function in vivo is much more difficult than originally anticipated. Here, we review the current status of IL-5 and IL-5 receptor research, with emphasis on strategies to interfere with IL-5 function.
Prostamide F2α receptor antagonism combined with inhibition of FAAH may block the pro‐inflammatory mediators formed following selective FAAH inhibition (2013)

This article is part of a themed section on Cannabinoids 2013. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-6.
Low anisotropic upper critical fields in SmO 1− x F x FeAs thin films with a layered hybrid structure (2019)

Abstract We report on the upper critical fields in SmO 1− x F x FeAs thin films prepared by pulsed laser deposition. With an F-content gradient along their thickness, the films could be described approximately as layered two-phase hybrid structures comprised of one superconducting layer and one antiferromagnetic layer. An analytical characterization of different thin film samples by Auger electron spectroscopy and energy-dispersive x-ray spectroscopy in scanning transmission electron microscopy is provided and structural defects, such as antiphase boundaries, were confirmed for films grown at lower deposition temperatures. Electrical transport measurements in pulsed magnetic fields yielded upper critical fields higher than 80 T with an anisotropy γ Hc2 ≤ 2.25.
FM/FSK characterization of tunable two-electrode DFB lasers and their performance with noncoherent detection (1990)

Optical FDM and FSK systems require frequency tunable lasers with large and flat FM response magnitude and phase. Such lasers include frequency tunable two-electrode DFB lasers,1 which have been used recently in FSK based communcation systems.2 These lasers with two active sections have a larger FM bandwidth than tunable three-electrode DBR lasers with a modulated passive section, where the modulation rate is limited to ~200 Mbit/s.3 We characterized two-electrode DFB lasers for use in FSK systems by measuring the FM response magnitude and FSK spectra at various modulation rates. We subsequently relate these characteristics to bit-error-rate (BER) measurements in a noncoherent detection communication system in which the FSK signal is converted to an ASK format by an optical filter.4 Thus we relate directly basic device characteristics of these lasers to system performance.
Synthesis of SHIP1‐Activating Analogs of the Sponge Meroterpenoid Pelorol (2012)

Abstract Two biomimetic approaches have been used to synthesize analogs of the SHIP1‐activating sponge meroterpenoid pelorol ( 1 ). One approach started from the chiral pool plant natural product sclareolide, which has the same absolute configuration as pelorol. The second approach utilized an enantioselective polyene cyclization to efficiently access both absolute configurations of the pelorol meroterpenoid skeleton and to prepare A‐ring functionalized compounds. Selected analogs have been evaluated for water solubility and biological activity. It was found that the undesirable catechol and ester functionalities in 1 could be removed to give MN100 ( 3 ), without a decrease in SHIP1‐activating ability. A further refinement led to the resorcinol analog 18 , which is the most effective SHIP1‐activating pelorol analog made to date. The HCl salt of ent ‐ 28 , a C‐3 amino analog of 18 , is about 500,000‐fold more soluble in water than MN100 ( 3 ). (±)‐ 28·HCl activates SHIP1 in vitro, inhibits Akt phosphorylation in stimulated MOLT‐4 (SHIP+) cells, and is active in a dose‐dependent manner in a mouse model of inflammation when administered by oral gavage (ED 50 ≈ 0.1 mg/kg). Pelorol analogs ent ‐ 28 or (±)‐ 28 are promising chemical tools for further preclinical in vivo evaluation of the potential of SHIP1 activators as therapeutics for treating hematopoietic diseases involving aberrant activation of PI3K cell signaling.
Efficacy of Rizatriptan for Menstrual Migraine in the Treat A Migraine Early (TAME) Studies (2006)

Martin, Vincent MD; Cady, Roger MD; Mauskop, Alexander MD; Seidman, Larry S. DO, MBA; Rodger, Anthony MS; Skobieranda, Franck MD Author Information