gebhart/patrepeval huggingface dataset:
A Value Network Model for Strategic Analysis (2008)

This paper describes a new framework for modeling value network of inter-organization interactions. We propose a set of building blocks elements of the model made of economic entities and offering transfers and describe a methodology that configures a business or organization network based on maximizing the consumption of the common value proposition.
Er comb fiber laser with fceo noise below 0.2 rad (2015)

We demonstrate an all polarization-maintaining Er fiber frequency comb with a record low phase noise for the locked carrier envelope offset frequency of 0.18 rad.
Fasudil Decreases Lesion Burden in a Murine Model of Cerebral Cavernous Malformation Disease (2011)

This represents the first report of therapeutic benefit of pharmacological therapy in development and progression of CCMs and indicates that Rho kinase activation is a critical step in CCM lesion genesis and maturation.
Targeting DNA Binding for NF-κB as an Anticancer Approach in Hepatocellular Carcinoma (2018)

Quinoline core has been shown to possess a promising role in the development of anticancer agents. However, the correlation between its broad spectrum of bioactivity and the underlying mechanism of actions is poorly understood. The present study, with the use of bioinformatics approaches, reported a series of designed molecules which integrated quinoline core and sulfonyl moiety, with the objective of evaluating the substituent and linker effects on anticancer activities and associated mechanistic targets. We identified potent compounds (<b>1h</b>, <b>2h</b>, <b>5</b> and <b>8</b>) exhibiting significant anticancer effects towards liver cancer cells (Hep3B) with the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2<i>H</i>-tetrazolium (MTS) relative values of cytotoxicity below 0.40, a value in the range of doxorubicin positive control with the value of 0.12. Bulky substituents and the presence of bromine atom, as well as the presence of sulfonamide linkage, are likely the favorable structural components for molecules exerting a strong anticancer effect. To the best of our knowledge, our findings obtained from chemical synthesis, in vitro cytotoxicity, bioinformatics-based molecular docking analysis (similarity ensemble approach, SEA),and electrophoretic mobility shift assay provided the first evidence in correlation to the anticancer activities of the selected compound <b>5</b> with the modulation on the binding of transcription factor NF-κB to its target DNA. Accordingly, compound <b>5</b> represented a lead structure for the development of quinoline-based NF-κB inhibitors and this work added novel information on the understanding of the mechanism of action for bioactive sulfonyl-containing quinoline compounds against hepatocellular carcinoma.
Dendritic cells stimulated with a bacterial product, OK-432, efficiently induce cytotoxic T lymphocytes specific to tumor rejection peptide. (2003)

Dendritic cells (DCs) are potent antigen-presenting cells, which have recently been applied for cancer immunotherapy using epitope peptides. Accumulating results of the clinical trials of such a strategy suggest that maturity of the applied DCs has a significant impact on the outcome of the vaccination. Here we examined the effects of penicillin-killed Streptococcus pyogenes (OK-432) on DC maturation and functions including induction of CTLs. DCs generated from peripheral blood using granulocyte macrophage colony-stimulating factor and interleukin (IL)-4 showed immunophenotypes consistent with immature DCs (iDCs). These iDCs were further incubated with medium alone, tumor necrosis factor alpha, lipopolysaccharide, or OK-432. The immunophenotypical analysis showed DCs stimulated with OK-432 (OK-DCs) possessed significantly higher expression of CD83 compared with unstimulated DCs. Furthermore, OK-DCs showed significantly higher production of IL-12 and IFN-gamma compared with DCs with other stimulations. These results indicate that OK-432 stimulates iDCs to have a mature phenotype and to produce a significant amount of T-helper 1-type cytokines. To examine the potency of OK-DCs on the induction of specific CTLs, the tumor rejection peptide derived from carcinoembryonic antigen was used as a model antigen. The HLA-tetramer assay showed that potent CTL was induced with OK-DCs at high frequency. These results indicate that OK-432 efficiently stimulates DCs without interfering with the presentation of pulsed peptide. Furthermore, OK-432 does not activate nuclear factor kappaB through Toll-like receptor 2 or Toll-like receptor 4 in the indicator cell system; however, it induces IL-12 production through the beta(2) integrin system on DCs. These results strongly suggest that OK-432 could be applied to develop an efficient cancer vaccine using DCs pulsed with tumor rejection peptides.
Time-lapse imaging of wild-type trypanosomes expressing histone 2B-GFP together with cytosolic GFP or DsRED. (2016)

Images\nwere acquired using a Nikon TE2000E-PFS microscope with a 60x objective. DIC\nand fluorescent images were taken every 10 minutes for 24 hours.
High-dose chemotherapy with autologous stem cell support for first-line treatment of aggressive non-Hodgkin lymphoma: a systematic review and meta-analysis based on individual patient data (2016)

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: 1. To examine the effect of high‐dose chemotherapy regimens with autologous stem cell transplantation versus conventional chemotherapy on overall survival and progression‐free survival in patients with aggressive non‐Hodgkin lymphoma. 2. To identify factors that modify the effect of HD‐ASCT on overall survival and progression‐free survival in patients with aggressive non‐Hodgkin lymphoma.
Neoadjuvant Stereotactic Body Radiotherapy After Upfront Chemotherapy Improves Pathologic Outcomes Compared With Chemotherapy Alone for Patients With Borderline Resectable or Locally Advanced Pancreatic Adenocarcinoma Without Increasing Perioperative Toxicity (2022)

Despite having more advanced disease, the nCT-SBRT cohort was still more likely to undergo an R0 resection and experienced similar survival outcomes compared with the nCT alone cohort.
Consensus development in acute renal failure: the Acute Dialysis Quality Initiative (2005)

Broad consensus in the diagnosis and management of acute renal failure and in the use of blood purification in nonrenal critical illness is achievable. Standardization of definitions, practice, and research methodology is urgently needed, and specific proposals have been made by an international, interdisciplinary group.
Compatibilization of Polymer Blends from Poly(butadiene‐g‐poly(styrene‐co‐acrylonitrile)) and Polycarbonate through Oxazoline‐ and Benzoxazole‐Modification of ABS (2004)

Abstract Blends of poly(butadiene‐g‐poly(styrene‐co‐acrylonitrile) (ABS) with polycarbonate (PC) are some of the most successful multiphase materials, with applications in the automotive and electronics industries. The mechanical properties of the complete incompatible blends are mainly determined by the interaction between the poly(styrene‐co‐acrylonitrile) (S/AN) component of the ABS and the PC as well as through the dispersion of the elastomeric component poly(butadiene) in the thermoplastic S/AN‐matrix. The aim of our work is to optimize the modification process by the use of new substituted amino alcohols and amino phenols, as well as the use of a more efficient catalyst. Both reactive and non reactive compatibilization of polymer blends should be performed with the new ABS‐modifications.
Adapting the number of antennas and power to traffic load: When to turn on massive MIMO? (2018)

In this work, we consider the downlink of a multi-user multiple-input multiple-output (MIMO) system and aim to find the jointly optimal number of base station (BS) antennas and transmission powers that minimize the power consumption while satisfying each user's signal-to-interference-and-noise-ratio (SINR) constraint and the BS's power constraint. Different from prior work, we consider a power consumption model that takes both transmitted and hardware-consumed power into account. We formulate the joint optimization problem for a single-cell system and derive closed-form expressions for the optimal number of BS antennas and transmission powers. The solution can be utilized in practice to turn on and off antennas depending on the traffic load variations. Substantial power savings are demonstrated by simulation.
Minimising Power Consumption to Achieve More Eﬃcient Green Cellular Radio Base Station Designs (2012)

The last ten years have witnessed explosive growth in the number of subscribers for mobile telephony. The technology has evolved from early voice only services to text messaging through to today’s mobile wireless (Internet) data delivery. The increasing use of wireless connectivity via smartphones and laptops, predominantly for high bandwidth video streaming, has led to an exponential surge in network traﬃc. Meeting these mobile traﬃc demands isFundamentals,causing a signiﬁcant increase in operator energy cost, as an enlarged network of radio base stations is needed to support mobile broadband eﬀectively and maintain operational competitiveness. This chapter thus explores approaches which will assist in delivering signiﬁcant energy eﬃciency gains in future wireless networks. It will investigate several approaches to saving energy in future wireless networks. These include: femtocell and relay deployments; optimizing multiple antenna systems; sleep mode techniques to disable radio transmissions whenever possible; reallocating transmissions under low load; and improving the power ampliﬁer. The impact of these approaches on achieving more energy eﬃcient cellular wireless communication systems is discussed.
Urinary Catecholamine Response to Glucagon in Young and Elderly Patients with Essential Hypertension† (1980)

The role of the sympathetic nervous system (SNS) in essential hypertension was evaluated by examining the response of urinary catecholamines to the intramuscular injection of glucagon in both young and elderly normal subjects (total 16) and in both young and elderly patients with essential hypertension (total 16). Urine was collected for 2 hours before glucagon injection and for 2 and 4 hours after injection, for determination of adrenaline and noradrenaline. The increments of urinary adrenaline and noradrenaline after glucagon injection were significantly higher in young hypertensive than in young normotensive subjects or in normotensive and hypertensive elderly subjects. The observation that the reactivity of the SNS is increased in young patients with essential hypertension lends support to the hypothesis that the SNS is more important in the maintenance of hypertension in the young than in the elderly.
Microwave noise properties of heterojunction bipolar transistors (2014)

The broadband noise performance of silicon germanium (SiGe) and compound semiconductor (CS) heterojunction bipolar transistors (HBTs) is presented. The key noise mechanisms in HBTs are summarized to provide a framework through which the noise limitations of the devices can be understood. Process related details and transport physics of each class of device are then compared and contrasted with a focus on details relevant to the broadband noise performance. Fundamental noise performance limitations are presented for exemplary InP/InGaAs/InP BiCMOS DHBTs and SiGe HBTs. The state-of-the-art for SiGe and CS HBTs operating in the 1-300 GHz frequency range is reviewed and interpreted in the context of fundamental performance limitations. Finally, the paper concludes with a discussion of how the performance of future HBT technology generations should improve.
Long-term adverse events (AE) in patients with metastatic castration-resistant prostate cancer (mCRPC) receiving prostate-specific membrane antigen (PSMA)-based targeted radionuclide therapy (TRT). (2021)

5055 Background: PSMA-TRT is a promising investigational treatment for patients with mCRPC. Expected short-term toxicities associated with PSMA-TRT include dose-dependent myelosuppression and xerostomia. However, there is a lack of information regarding long-term effects of PSMA-TRT on marrow, renal, and liver function. Additionally, potential organ dose limits for radiation are derived from studies of external beam radiation, which may not be applicable to TRT. Methods: Men treated on prospective clinical trials of PSMA-TRT, from 2003 through 2020 with at least six months of follow-up were included. Variables included treatment, co-morbidities, baseline and most recent renal, liver, and marrow function, along with respective short-term ( &lt; 6 months) and long-term toxicities. AEs were graded using CTCAE version 5 and attribution was assessed with most recent clinical follow up. Multivariable logistic regression was used to control for type of TRT, comorbidities, and subsequent therapies. Results: 71 (59.7%) patients who received 177Lu-J591, 30 (25.2%) 177Lu-PSMA-617, 11 (9.2%) 225Ac-J591, and 7 (5.9%) 90Y-J591 were included, with median follow up 18 months (range 6-133). Long-term (most recent) laboratory values and AEs are summarized in the table. A majority of AEs were attributed to alternate etiologies. 5 of 14 cases of grade (Gr) ≥2 creatinine increase, 3 of 36 cases of Gr ≥2 platelets, 2 of 14 cases of Gr ≥2 bilirubin, 1 of 15 cases of Gr ≥2 AST increase, and 1 of 5 cases of Gr ≥2 ALT increase were deemed possibly related to PSMA-TRT. Only two Gr ≥3 AEs were attributed to possibly being related to PSMA-TRT: one case of Gr 4 creatinine elevation and one case of Gr 3 ALT elevation. On multivariable analysis, alpha-TRT was associated with hepatic AEs (OR 4.38, p = 0.047), and there was a trend towards higher Charlson Comorbidity scores associating with hematologic AEs (OR 1.27, p = 0.095). Conclusions: This is the largest analysis to-date of long-term AEs in patients who have received PSMA-TRT. Long-term effects on renal, liver, and marrow function are infrequent.[Table: see text]
Partial Oxidation of Propane: Single-Site Pd/γ-Al2O3 Catalysts (2023)

The paper proposes a method for synthesizing a heterogeneous catalyst that contains single Pd sites on γ-Al2O3 surface. This method involves preliminary heterogenization of a Pd complex with a hydroxyquinone (e.g., alizarin) on the γ-Al2O3 surface, followed by hydrogenolysis of the Pd–alizarin bond, reduction of Pd(II) into Pd(0), and removal of alizarin. The catalyst was examined by diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) and tested in propane oxidation into key petrochemicals. During the test, the catalyst exhibited high activity (242 mol of the product per g-at Pd per hour).
Phosphorescent Platinum(II) Complexes with C^C* Cyclometalated NHC Dibenzofuranyl Ligands: Impact of Different Binding Modes on the Decay Time of the Excited State (2015)

Two C^C* cyclometalated platinum(II) N-heterocyclic carbene (NHC) complexes with the general formula [(C^C*)Pt(O^O)] (C^C*=1-dibenzofuranyl-3-methylbenzimidazolylidene; O^O=dimesitoylmethane) have been synthesized and extensively characterized, including solid-state structure determination, (195) Pt NMR spectroscopy, and 2D NMR (COSY, HSQC, HMBC, NOESY) spectroscopy to elucidate the impact of their structural differences. The two regioisomers differ in the way the dibenzofuranyl (DBF) moiety of the NHC ligand is bound to the metal center, which induces significant changes in their physicochemical properties, especially on the decay time of the excited state. Quantum yields of over 80 % and blue emission colors were measured.
Growing Method of a Large Synthetic Diamond Single Crystal. (1993)

Crystal growth mass is proportional to an area of a crystal surface. For producing a large diamond single crystal within a short time, we tried to use a large single seed crystal to obtain a single crystal immedately on it by the Temperature Gradient Method. A large single crystal, ten-carat size, was obtained within a short time, but many metal solvent inclusions were not removed in the above-mentioned seed crystal. The distribution of inclusions was relatee to morphologies. When a crystal grows into a hexagonal shape, a density of inclusions is minimized.
Narrowband Interference Issues in Ultra Wideband Systems (2005)

This chapter contains sections titled: Introduction Effect of NBI in UWB Systems Avoiding NBI Canceling NBI Conclusion and Future Research References
Hiding and absorbing the power emitted by a dipole at the interface of an indefinite medium (2012)

The power emitted by a dipole at the interface between an indefinite (hyperbolic) medium and an isotropic medium is analyzed. The theoretical estimation is performed by using a transmission line method for time-harmonic fields in layered isotropic materials. The indefinite medium can be constructed in different ways; here we analyze, as an example, the case of alternating two subwavelength layers of isotropic materials. We compute the power spectrum of transverse electric and magnetic (TE and TM) waves and show that the power emitted by the dipole is mainly coupled into the indefinite medium underneath, opening up several application scenarios, such as innovative carpet cloaking implementations and super absorbers.
Water restriction and bone metabolism in camels (1996)

'Krafft disease', occurring in camels living in the very arid areas of North Africa, is characterized by spontaneous fractures of costal and/or appendicular bones. To better understand the mechanisms of this, we studied the influence of water restriction on plasma and urinary markers of bone metabolism in camels. Eight 2-year-old nonpregnant, nonlactating camels were studied at the research station of Laâyoune (Morocco). After a 10 day period of daily watering, five animals were watered only every 10th day over a 50 day period, then again watered daily for a final 10 day period (rehydration). The three control animals were watered daily throughout the whole experimental period (70 days). Each camel was fed a ration of straw, luceme hay and barley, resulting in a daily intake of 25 g calcium and 11 g phosphorus. Water restriction induced a decrease in daily urinary volume and an increase in plasma osmolality. These symptoms of dehydration were not associated with any significant change either in the markers of osteoblastic activity (plasma alkaline phosphatase activity and osteocalcine concentration) or in the markers of bone resorption (urinary excretion of calcium, hydroxyproline pyridinoline and deoxypyridinoline). Thus, in well-fed camels, water restriction did not affect bone metabolism. However, no conclusions were possible regarding the influence of dehydration or calcium and/or phosphorus deficiency in the etiology of 'Kraft disease'.
Oxidative cyclization of some 1-Aryl-5-(tetrazol-5-ylmethyl)pyrrolidin-2-ones and of a related piperidin-2-one. Preparation of fused tetracyclic tetrazolobenzodiazepinone derivatives (2000)

In contrast to compounds of type 1a, compounds 1c–1i, when treated with lead(IV) acetate or cerium(IV) ammonium nitrate, underwent oxidative cyclizations to afford the corresponding compounds of type 3 with both oxidants, while oxidation of compound 1p afforded compound 2a (m = n = 1).
A Weak Invariance Principle with Applications to Domains of Attraction (1978)

An elementary probabilistic argument is given which establishes a "weak invariance principle" which in turn implies the sufficiency of the classical assumptions associated with the weak convergence of normed sums to stable laws. The argument, which uses quantile functions (the inverses of distribution functions), exploits the fact that two random variables $X = F^{-1}(U)$ and $Y = G^{-1}(U)$ are, in a useful sense, close together when $F$ and $G$ are, in a certain sense, close together. Here $U$ denotes a uniform variable on (0, 1). By-products of the research are two alternative characterizations for a random variable being in the domain of partial attraction to a normal law and some results concerning the study of domains of partial attraction.
Permanent magnet volume minimization in permanent magnet assisted synchronous reluctance motors (2013)

In the recent years the study on new motor topologies for automotive applications has found an increasing interest. The environmental impact of conventional internal combustion engine, together with the increasing demand and the cost of the oil, are two of the main reasons that makes electric motors an attractive alternative. Machines that employ interior permanent magnet configurations are widely recognized as good performance motors for traction applications. On the other hands, the exponential increase of the price of rare earths magnets in the last years, is making rare earth motors a very expensive solution. This encourage the research of low cost, rare earth free alternatives, represented by the permanent magnet assisted synchronous reluctance machines. Three different magnet dimension configurations have been considered. This research highlights the influence and benefits of the insertion of ferrite on the machine performance, emphasizing the importance of a careful evaluation of the magnet quantity in order to optimize the performance and reduce the total cost.
Deceiving Google's Cloud Video Intelligence API Built for Summarizing\n Videos (2017)

Despite the rapid progress of the techniques for image classification, video\nannotation has remained a challenging task. Automated video annotation would be\na breakthrough technology, enabling users to search within the videos.\nRecently, Google introduced the Cloud Video Intelligence API for video\nanalysis. As per the website, the system can be used to "separate signal from\nnoise, by retrieving relevant information at the video, shot or per frame"\nlevel. A demonstration website has been also launched, which allows anyone to\nselect a video for annotation. The API then detects the video labels (objects\nwithin the video) as well as shot labels (description of the video events over\ntime). In this paper, we examine the usability of the Google's Cloud Video\nIntelligence API in adversarial environments. In particular, we investigate\nwhether an adversary can subtly manipulate a video in such a way that the API\nwill return only the adversary-desired labels. For this, we select an image,\nwhich is different from the video content, and insert it, periodically and at a\nvery low rate, into the video. We found that if we insert one image every two\nseconds, the API is deceived into annotating the video as if it only contained\nthe inserted image. Note that the modification to the video is hardly\nnoticeable as, for instance, for a typical frame rate of 25, we insert only one\nimage per 50 video frames. We also found that, by inserting one image per\nsecond, all the shot labels returned by the API are related to the inserted\nimage. We perform the experiments on the sample videos provided by the API\ndemonstration website and show that our attack is successful with different\nvideos and images.\n
Supplementary Figure 1 from Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion (2023)

&lt;p&gt;PDF file, 31K, EPHA4 in the Boston cohort.&lt;/p&gt;
A simple mechanism for stabilizing network queues in TCP/IP networks (2006)

Abstract In this paper we determine the stability bounds for the DRED active queue management (AQM) algorithm using a previously developed nonlinear dynamic model of TCP. We develop a second‐order linear model with time delay by linearizing the nonlinear model. Using the Pade approximation of time‐delayed system e − R 0 s , where R 0 is the delay in the system, we then determine the range of stabilizing gains of DRED when controlling the second‐order system with time delay R 0 . We also present examples showing the stability bounds of the DRED controller gain for networks with different parameters such as link capacity, load level, and round‐trip time. In addition, we describe an efficient implementation of the DRED AQM algorithm. Copyright © 2006 John Wiley &amp; Sons, Ltd.