gebhart/patrepeval huggingface dataset:
Hydrostatic countercurrent chromatography and ultra high pressure LC: Two fast complementary separation methods for the preparative isolation and the analysis of the fragrant massoia lactones (2010)

Using a one-step preparative hydrostatic countercurrent chromatography method, the fragrant massoia lactones were purified from the crude massoia bark oil, in less than 3 h. The fractionation was performed with the biphasic solvent system c-hexane-methanol-water (10:9:1, v/v/v), leading to target compounds with purity over 96%, as determined by GC-MS and ultra high pressure LC-MS analyses. Together with C-10, C-12 and C-14 massoia lactones, two other aromatic compounds used in perfumes, benzyl benzoate and benzyl salicylate, were also obtained as pure compounds. In parallel, an easy and efficient ultra high pressure LC method was developed for the ultra-fast analysis of massoia lactones, as an alternative to long GC-MS methods.
Pharmacological identification of two types of presynaptic voltage- dependent calcium channels at CA3-CA1 synapses of the hippocampus (1994)

The effects of voltage-dependent Ca channel (VDCC) antagonists on synaptic transmission were investigated at CA3-CA1 synapses of guinea pig hippocampal slices. After selectively loading presynaptic structures in area CA1 with the calcium indicator fura-2, we simultaneously recorded a presynaptic calcium transient ([Ca]t) and the corresponding field excitatory postsynaptic potential (fEPSP) evoked by a single stimulus given to the Schaffer collateral-commissural (SCC) pathway. Application of nifedipine did not reduce either the [Ca]t of the fEPSP, suggesting that nifedipine-sensitive Ca channels do not significantly contribute to evoked synaptic transmission at low stimulation frequency. Application of omega-conotoxin GVIA (omega-CgTX) or omega-agatoxin-IVA (omega-Aga-IVA) dose-dependently blocked both the [Ca]t and the fEPSP. The time course of the block of the [Ca]t was similar to that of the fEPSP. About 40% of the total [Ca]t was omega-CgTX sensitive, and more than 20% was omega-Aga-IVA sensitive. Combined application of these two blockers showed no overlap of the omega-CgTX-sensitive with the omega-Aga-IVA-sensitive [Ca]t. These results suggest that there are at least two types of presynaptic VDCCs at CA3-CA1 synapses of the hippocampus: omega-CgTX-sensitive and omega-Aga-IVA-sensitive Ca channels. Our results also suggest that these two types of Ca channels are colocalized at a single presynaptic terminal. During application of omega-CgTX or omega-Aga-IVA, the initial slope of the fEPSP varied approximately as the fourth power of the amplitude of the [Ca]t, suggesting that omega-CgTX-sensitive and omega-Aga-IVA-sensitive Ca channels have about equal efficacy in triggering transmitter release. These results in combination with similar findings at the squid giant synapse suggest that the nonlinear relationship between transmitter release and the Ca influx is well conserved from the molluscan to the mammalian nervous system.
A proposal of doubly coupled resonator optical waveguides (2012)

We propose doubly-coupled resonator optical waveguides (D-CROWs). D-CROWs are composed by introducing 1-D photonic crystals (PC) structure into the ring resonator based CROWs. We show D-CROWs achieve small group velocity compared with conventional 1-D PC-CROWs.
Synthesis and Total 1H- and 13C-NMR Assignment of Cephem Derivatives for Use in ADEPT Approaches (2008)

We report the synthesis and total NMR characterization of 5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid-3-[[[(4''-nitrophenoxy)carbonyl]oxy]-methyl]-8-oxo-7-[(2-thienyloxoacetyl)amino]-diphenylmethyl ester-5-dioxide (5), a new cephalosporin derivative. This compound can be used as the carrier of a wide range of drugs containing an amino group. The preparation of the intermediate product, 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid-3-[methyl 4-(6-methoxyquinolin-8-ylamino)pentylcarbamate]-8-oxo-7-[(2-thienyloxoacetyl)amino]-diphenylmethyl ester-5-dioxide (6), as well as the synthesis of the antimalarial primaquine prodrug 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid-3-[methyl 4-(6-methoxyquinolin-8-ylamino)pentylcarbamate]-8-oxo-7-[(2-thienyloxoacetyl)amino]- 5-dioxide (7) are also described, together with their total (1)H- and (13)C-NMR assignments.
One-year water-ageing of calcium phosphate composite containing nano-silver and quaternary ammonium to inhibit biofilms (2016)

Dental composites are commonly used restorative materials; however, secondary caries due to biofilm acids remains a major problem. The objectives of this study were (1) to develop a composite containing quaternary ammonium dimethacrylate (QADM), nanoparticles of silver (NAg), and nanoparticles of amorphous calcium phosphate (NACP), and (2) to conduct the first investigation of the mechanical properties, biofilm response and acid production vs water-ageing time from 1 day to 12 months. A 4 × 5 design was utilized, with four composites (NACP-QADM composite, NACP-NAg composite, NACP-QADM-NAg composite, and a commercial control composite), and five water-ageing time periods (1 day, and 3, 6, 9, and 12 months). After each water-ageing period, the mechanical properties of the resins were measured in a three-point flexure, and antibacterial properties were tested via a dental plaque biofilm model using human saliva as an inoculum. After 12 months of water-ageing, NACP-QADM-NAg had a flexural strength and elastic modulus matching those of the commercial control (P>0.1). Incorporation of QADM or NAg into the NACP composite greatly reduced biofilm viability, metabolic activity and acid production. A composite containing both QADM and NAg possessed a stronger antibacterial capability than one with QADM or NAg alone (P<0.05). The anti-biofilm activity was maintained after 12 months of water-ageing and showed no significant decrease with increasing time (P>0.1). In conclusion, the NACP-QADM-NAg composite decreased biofilm viability and lactic acid production, while matching the load-bearing capability of a commercial composite. There was no decrease in its antibacterial properties after 1 year of water-ageing. The durable antibacterial and mechanical properties indicate that NACP-QADM-NAg composites may be useful in dental restorations to combat caries.
Auditory and visual hallucinations after influenza vaccine: a case report (2016)

Vaccination against influenza was found in geriatric patients to correlate with a reduced risk of death, hospitalization and costs on health system [Nichol et al. 1994]; vaccination against influenza is indeed recognised by the World Health Organization as an efficacious strategy to prevent the health-threatening effects of influenza viruses [World Health Organization, 2012]. As with all drugs, the vaccine against influenza is associated with some adverse drug reactions (ADRs) [Vaxigrip, 2015]; while some neurological and psychiatric ADRs have been reported no evidence of visual and auditory hallucination exists. A case of extended hallucinations is now reported.
Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically Prevents Rab Prenylation in Osteoclasts and Macrophages (2001)

Nitrogen-containing bisphosphonate drugs inhibit bone resorption by inhibiting FPP synthase and thereby preventing the synthesis of isoprenoid lipids required for protein prenylation in bone-resorbing osteoclasts. NE10790 is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak anti-resorptive agent. Although NE10790 was a poor inhibitor of FPP synthase, it did inhibit prenylation in J774 macrophages and osteoclasts, but only of proteins of molecular mass approximately 22-26 kDa, the prenylation of which was not affected by peptidomimetic inhibitors of either farnesyl transferase (FTI-277) or geranylgeranyl transferase I (GGTI-298). These 22-26-kDa proteins were shown to be geranylgeranylated by labelling J774 cells with [(3)H]geranylgeraniol. Furthermore, NE10790 inhibited incorporation of [(14)C]mevalonic acid into Rab6, but not into H-Ras or Rap1, proteins that are modified by FTase and GGTase I, respectively. These data demonstrate that NE10790 selectively prevents Rab prenylation in intact cells. In accord, NE10790 inhibited the activity of recombinant Rab GGTase in vitro, but did not affect the activity of recombinant FTase or GGTase I. NE10790 therefore appears to be the first specific inhibitor of Rab GGTase to be identified. In contrast to risedronate, NE10790 inhibited bone resorption in vitro without markedly affecting osteoclast number or the F-actin "ring" structure in polarized osteoclasts. However, NE10790 did alter osteoclast morphology, causing the formation of large intracellular vacuoles and protrusion of the basolateral membrane into large, "domed" structures that lacked microvilli. The anti-resorptive activity of NE10790 is thus likely due to disruption of Rab-dependent intracellular membrane trafficking in osteoclasts.
Mojette transform based LDPC erasure correction codes for distributed storage systems (2017)

Mojette Transform (MT) based erasure correction coding possesses extremely efficient encoding/decoding algorithms and demonstrate promising burst erasure recovery performance. MT codes are based on discrete geometry and provide redundancy through creating projections. Projections are made of smaller data structures called bins and are generated from a two dimensional convex-shaped data. For exact data recovery, only a subset of projections are needed by the decoder. We realize that the discrete geometry definition of MT erasure codes corresponds to creating structured/deterministic generator matrices. In this study, we show an alternative Low Density Parity Check (LDPC) code construction methodology through investigating parity check matrices of MT codes which shows sparseness as the blocklength of the code gets large. In a distributed storage setting, we also quantify the repair bandwidth and show that this novel interpretation can be used to facilitate bin-level local repairs.
Alternative polyadenylation: An untapped source for prostate cancer biomarkers and therapeutic targets? (2021)

The full extent of cancer-associated and tissue-specific APA events have yet to be defined, and the mechanisms and functional consequences of APA in cancer remain incompletely understood. There is evidence that APA is active in PCa, and that it may be an untapped resource for PCa biomarkers or therapeutic targets.
An application of fixed-rate scalar-vector quantization in image coding (2002)

Considers an application of a structured, fixed-length vector quantizer, called the scalar-vector quantizer, to image coding. The scalar-vector quantizer, while using fixed-length codewords, achieves a rate-distortion performance close to that of the optimum variable-length encoded scalar quantizer. In the paper, an adaptive 2D DCT coding system is developed in which the DCT coefficients are quantized by scalar-vector quantizers. It is shown that performance comparable to variable-length coding systems can be achieved while maintaining a fixed encoding rate. Preliminary results on the performance of the proposed system when employed over a noisy channel, along with a simple error mitigation mechanism are also provided.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
OLTP on hardware islands (2012)

Modern hardware is abundantly parallel and increasingly heterogeneous. The numerous processing cores have nonuniform access latencies to the main memory and to the processor caches, which causes variability in the communication costs. Unfortunately, database systems mostly assume that all processing cores are the same and that microarchitecture differences are not significant enough to appear in critical database execution paths. As we demonstrate in this paper, however, hardware heterogeneity does appear in the critical path and conventional database architectures achieve suboptimal and even worse, unpredictable performance. We perform a detailed performance analysis of OLTP deployments in servers with multiple cores per CPU ( multicore ) and multiple CPUs per server ( multisocket ). We compare different database deployment strategies where we vary the number and size of independent database instances running on a single server, from a single shared-everything instance to fine-grained shared-nothing configurations. We quantify the impact of non-uniform hardware on various deployments by (a) examining how efficiently each deployment uses the available hardware resources and (b) measuring the impact of distributed transactions and skewed requests on different workloads. Finally, we argue in favor of shared-nothing deployments that are topology- and workload-aware and take advantage of fast on-chip communication between islands of cores on the same socket.
Photochemical long-range pinacol rearrangement. Mechanistic and exploratory organic photochemistry (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical long-range pinacol rearrangement. Mechanistic and exploratory organic photochemistryHoward E. Zimmerman and John M. NussCite this: J. Org. Chem. 1986, 51, 24, 4604–4617Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://doi.org/10.1021/jo00374a022RIGHTS & PERMISSIONSArticle Views314Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The 5-GHz Airport Surface Area Channel—Part II: Measurement and Modeling Results for Small Airports (2008)

This paper describes results from a channel measurement campaign performed at several small airports in the U.S. in the 5-GHz band. This paper is a companion to another paper, which describes channel models for large airports. We classify the small airport surface channel into three propagation regions based upon different delay dispersion conditions. The channel characteristics of these regions in the delay and frequency domains are discussed with examples. We provide empirical stochastic channel models (of different bandwidths) to accurately represent the channel on the airport surface area for all propagation regions. The models are provided in the form of tapped delay lines, and complete statistical tap descriptions are given. Several key observations, including the presence of severe amplitude fading, some correlated scattering, and statistically nonstationary behavior, are also discussed.
Design of a low-latency, high-reliability wireless communication system for control applications (2014)

High-performance industrial control systems with tens to hundreds of sensors and actuators use wired connections between all of their components because they require low-latency, high-reliability links to maintain stability; however, the wires cause many mechanical problems that moving to wireless links would solve. No existing or proposed wireless system can achieve the latency and reliability required by the control algorithms because they are designed for either high-throughput or low-power communication between a pair or a small number of terminals. A preliminary wireless system architecture is proposed that focuses on low-latency operation through the use of reliable broadcasting, semi-fixed resource allocation, and low-rate coding. For an industrial printer application with 30 nodes in the control loop and a moderate information throughput of 4.8Mb/s, the system can achieve latencies under 2ms for SNRs above 7dB.
Erratum to: Suspended superconducting weak links from aerosol-synthesized single-walled carbon nanotubes (2020)

The article “ Suspended superconducting weak links from aerosol-synthesized single-walled carbon nanotubes ” written by Jukka-Pekka Kaikkonen 1 , Abhilash Thanniyil Sebastian 1 , Patrik Laiho 3 , Nan Wei 3 , Marco Will 1,2 , Yongping Liao 3 , Esko I. Kauppinen 3 , and Pertti J. Hakonen 1,2 , was originally published Online First without Open Access. After publication online first, the author decided to opt for Open Choice and to make the article an Open Access publication. Therefore, the copyright of the article has been changed to © The Author(s) 2020 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/ ), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The original article has been corrected.
Brain Networks That Track Musical Structure (2005)

As the functional neuroimaging literature grows, it becomes increasingly apparent that music and musical activities engage diverse regions of the brain. In this paper I discuss two studies to illustrate that exactly which brain areas are observed to be responsive to musical stimuli and tasks depends on the tasks and the methods used to describe the tasks and the stimuli. In one study, subjects listened to polyphonic music and were asked to either orient their attention selectively to individual instruments or in a divided or holistic manner across multiple instruments. The network of brain areas that was recruited changed subtly with changes in the task instructions. The focus of the second study was to identify brain regions that follow the pattern of movement of a continuous melody through the tonal space defined by the major and minor keys of Western tonal music. Such an area was identified in the rostral medial prefrontal cortex. This observation is discussed in the context of other neuroimaging studies that implicate this region in inwardly directed mental states involving decisions about the self, autobiographical memory, the cognitive regulation of emotion, affective responses to musical stimuli, and familiarity judgments about musical stimuli. Together with observations that these regions are among the last to atrophy in Alzheimer disease, and that these patients appear to remain responsive to autobiographically salient musical stimuli, very early evidence is emerging from the literature for the hypothesis that the rostral medial prefrontal cortex is a node that is important for binding music with memories within a broader music-responsive network.
Channel Aware Sparse Transmission for Ultra Low-Latency Communications in TDD Systems (2019)

Major goal of ultra reliable and low latency communication (URLLC) is to reduce the latency down to a millisecond (ms) level while ensuring reliability of the transmission. Since the current uplink transmission scheme requires a complicated handshaking procedure to initiate the transmission, to meet this stringent latency requirement is a challenge in wireless system design. In particular, in the time division duplexing (TDD) systems, supporting the URLLC is difficult since the mobile device has to wait until the transmit direction is switched to the uplink. In this paper, we propose a new approach to support a low latency access in TDD systems, called channel aware sparse transmission (CAST). Key idea of the proposed scheme is to encode a grant signal in a form of sparse vector. This together with the fact that the sensing mechanism preserves the energy of the sparse vector allows us to use the compressed sensing (CS) technique in CAST decoding. From the performance analysis and numerical evaluations, we demonstrate that the proposed CAST scheme achieves a significant reduction in access latency over the 4G LTE-TDD and 5G NR-TDD systems.
Experimental and theoretical study of the propagation of N waves through a turbulent medium (1994)

First Page
ChemInform Abstract: A Useful Approach to Tricyclic Compounds and Medium Ring Diketones through the Phosphoniosilylation Reaction. (1986)

Abstract The cycloalkenealdehydes (I) are treated with triphenylphosphine (II) and the silyl compound (III) to form the adducts (IV).
CARBON DIOXIDE OUTPUT DURING ANAESTHESIA (1977)

Department of Anaesthesia, University of Western Ontario, Victoria Hospital, and University Hospital, London, Ontario, Canada
Multi-Channel Harmonic Frequency Comb Covering the Mid-Infrared Molecular Fingerprint Region (2018)

We present a multi-channel, 0.1-mW/THz-level, 50-MHz-repetition-rate harmonic frequency comb covering the spectral range 18.5 – 85 THz (or 3.5 – 16 µm, or 625 – 2860 cm−1), based on intrapulse difference-frequency mixing within few-cycle, high-power 1.96-µm pulses.
Kinetics and mechanism of the reduction of protons to hydrogen by cobaltocene (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics and mechanism of the reduction of protons to hydrogen by cobaltoceneUlrich Koelle, Pierre P. Infelta, and Michael GraetzelCite this: Inorg. Chem. 1988, 27, 5, 879–883Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/ic00278a026https://doi.org/10.1021/ic00278a026research-articleACS PublicationsRequest reuse permissionsArticle Views1022Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts