gebhart/patrepeval huggingface dataset:
Evaluation of the effect of azapropazone on neutrophil migration in anaesthetized swine using a multichamber blister suction technique (1990)

1. The purpose of this study was to determine the in vivo inhibitory efficacy of azapropazone on neutrophil migration. The effects of azapropazone given at a dose of 100 mg kg-1 i.v. every 2 h on the neutrophil migration into skin inflammation sites (blister fluid) as well as into an autologous serum (+/- chemoattractant) placed above the blister surface (2nd chamber) were determined. 2. Azapropazone treatment schedule maintained blood levels at 70-100 micrograms ml-1 throughout the time course (360 min) of the experiment. 3. Azapropazone significantly inhibited (48 +/- 6%) neutrophil migration into the blister fluid (as evident from the decrease in myeloperoxidase activity). 4. Azapropazone significantly inhibited the neutrophil migration into the autologous serum either with (65 +/- 5%) or (35 +/- 6%) without the chemoattractant, formyl-methionyl-leucyl-phenylalanine (FMLP). The chemoattractant, FMLP, markedly increased neutrophil migration into the autologous serum by approximately 1.5 to 2 times the non-FMLP treated group. Azapropazone was more efficacious in inhibiting the neutrophil migration in the presence of FMLP than in its absence. 5. We conclude that azapropazone is an effective inhibitor of neutrophil migration into topically inflamed sites in anaesthetized swine.
Prediction and postdiction: Two frameworks with the goal of delay compensation (2008)

Abstract Although prediction is one of the key tasks of intelligent brains, it often proves impossible in an unpredictably changing world. Hence, brains often decide what happened retrospectively. This framework of postdiction, the opposite of prediction, stands as an alternative or complimentary framework to prediction. I further show how motor-sensory recalibration demonstrates delay compensation at the perceptual level.
Retrospective study comparing irinotecan and pegylated liposomal doxorubicin in treatment of recurrent platinum-refractory/resistant epithelial ovarian cancer. (2012)

The results indicate that CPT-11 is a promising drug for the treatment of platinum-resistant recurrent EOC.
TACT: Mobile Wireless Terminal for Digitally-Enabled Environments (2004)

In this paper, we introduce TACT, which is a general interaction tool for ubiquitous computing environments. This device is dedi-cated to the operation of various kinds of connections, including audio, video, and data transmission between remote/surrounding computers. With TACT, whenever a user wants to utilize a nearby computing resource, the user can open a session and manipulate its endpoints without caring about network addresses. We demon-strate a few typical scenarios to show how TACT is used in vari-ous situations. Categories and Subject Descriptors
An improved synthesis of enantiomerically pure RWJ 69442, a development candidate for the treatment of benign prostatic hyperplasia (2001)

Abstract This report describes an improved synthesis of enantiomerically pure ( S )‐2‐[4‐(Dimethylamino)phenyl]‐2,3‐dihydro‐ N ‐[2‐hydroxy‐3‐[4‐[2‐(1‐methylethoxy)‐phenyl]‐1‐piperazinyl]propyl]‐1,3‐dioxo‐1 H ‐isoindole‐5‐carboxamide (RWJ 69442), a potent and selective α la ‐adrenergic receptor antagonist for the treatment of benign prostatic hyperplasia. The synthesis highlights less hazardous reagents, easier purification and higher enantiomeric purity. The N ‐benzyl‐ N—t ‐butoxycarbonyl amine 6 could serve as an enantiomerically pure chiral building block for asymmetric synthesis.
Polypeptide hormone regulation of gene expression. Thyrotropin-releasing hormone rapidly stimulates both transcription of the prolactin gene and the phosphorylation of a specific nuclear protein. (1983)

The tripeptide hypothalamic releasing factor, thyrotropin-releasing hormone (TRH), rapidly increases prolactin gene transcription 7- to 12-fold in the GH4 rat pituitary cell line. The maximal rates of transcription are achieved within minutes and begin to attenuate within 1 h following addition of TRH. This transcriptional response appears to account for the observed effects of TRH on the accumulation of prolactin mRNA and the stimulation of prolactin biosynthesis. The rapid transcriptional effects of TRH include a large number of polymerase II-catalyzed transcription units. Addition of TRH to GH4 cell cultures also rapidly induces the phosphorylation of a 23,000-dalton chromatin-associated basic protein, distinct from known high mobility group or histone proteins and referred to as basic regulated phosphoprotein. The time course of TRH-stimulated prolactin transcription and basic regulated phosphoprotein phosphorylation demonstrates that the signal generated by TRH binding to its plasma membrane receptor rapidly reaches the cell nucleus.
CONCUSSION IN PROFESSIONAL FOOTBALL (2007)

This study addresses head responses causing concussion in National Football League players. Although efforts are underway to reduce impact acceleration through helmet padding, further study is needed of head kinematics after impact and their contribution to concussion, including rapid head displacement, z-axis rotation, and neck tension up to the time of maximum strain in the midbrain. Neck strength influences head deltaV and head injury criterion and may help explain different concussion risks in professional and youth athletes, women, and children.
CU Paste for Molded Interconnect Devices (2019)

Cu particles with an average particle size of 130 nm were found to be suitable for low-temperature metallization. Cu wirings with line/space (L/S) = 150 μm/150 μm and L/S = 150 μm/100 μm were formed by screen printing and aerosol jet printing, respectively. The shear strength of the Cu wiring that was covered by the SnBi solder including epoxy resin and liquid-crystalline polymer substrate was 7 MPa; the shear strength was maintained even after a high-temperature storage test (125 °C for 200 h). The developed Cu paste could be used as a via connection material, and employed for the fabrication of Cu wiring on two-dimensional and three-dimensional substrates.
Abstract WP99: Neuroprotective Therapy for Ischemia-Reperfusion Injury by Hemoglobin-albumin-cluster(Hemoact Tm ) (2017)

Background: A hemoglobin-albumin cluster designated as “HemoAct” was developed as a red blood cell substitute. It is composed of one core hemoglobin center wrapped covalently by three albumin shells. Since its particle size with a diameter of 10 nm is far smaller than red blood cell, it is expected to maintain good perfusion in the cerebral microvessels, leading to neuroprotective effects on ischemia-reperfusion (I/R) injury. Purpose: We aim to examine whether HemoAct have neuroprotective effects in rat transient middle cerebral artery occlusion (tMCAO) model, without toxic effects of hemoglobin, by administering it though the recanalized artery just before the onset of reperfusion. Subjects and Methods: Male Sprague-Dawley rats were subjected to 2-hour tMCAO by suture occlusion and then divided into four groups with respective treatments: (1) control group; no infusion, (2) vehicle group; infusion of PBS as the solvent (3) 0.5х HemoAct group; infusion of one-half diluted HemoAct (4) HemoAct group; infusion of undiluted HemoAct. Physical and neurological states, infarct and edema volumes, reactive oxygen species (ROS) and protease immunoblot levels were compared between the four groups after 24 hours of reperfusion. Microvascular hemoglobin perfusion and morphological states were compared between the control and HemoAct groups with immunohistochemical technique. Results: No significant changes were observed in blood pressure, pH, and blood gas after HemoAct infusion. Neurological symptoms were significantly less severe in the HemoAct group than in the other groups. Infarct and edema volumes were significantly smaller in the 0.5х HemoAct group (27.1%/15.2%) and the HemoAct group (20.2%/14.1%) than in the control group (55.2%/26.4%) and the vehicle group (53.2%/27.1%). ROS (4-HNE) and protease (MMP-9) immunoblot levels were significantly reduced in HemoAct group compared with the control and vehicle groups. Microvascular hemoglobin perfusion was more and microvascular narrowing changes was less in the HemoAct group than in the control group. Conclusion: HemoAct exhibited strong neuroprotective effects on I/R injury without toxic effects of hemoglobin. Superior microvascular perfusion of HemoAct may be a possible neuroprotective mechanism.
SOI Angular Rate Sensor with Open Beam Structure (2006)

An SOI (Silicon on Insulator) angular rate sensor with an open beam structure (OBS) has been designed and fabricated. To obtain good performance of the sensor, the FEM (Finite Element Method) analysis was carried out for several types of sensor structures to evaluate the vibration stability of the sensor. The stability of vibration modes was investigated by defining the independency between the excitation and detection vibration modes of the sensor structures. The FEM results showed the proposed OBS improved the independency by 60 times compared to the conventional structure.The OBS also made it possible to wire from electrodes beside the mass of the sensor to exterior bonding electrodes by mono-layer silicon on the SOI. Due to the easy wiring, the process became simple and low cost. The size of the sensor element was 1mm × 1mm × 0.5mm, and good linearity within +/- 0.5 % of the sensor output was obtained. The experimental results showed that the OBS provided fine sensor features; good stability in wide temperature range, and high precision. Therefore, this sensor is suitable for automotive applications, and has attained to mass production.
Chronic chemogenetic stimulation of the anterior olfactory nucleus reduces newborn neuron survival in the adult mouse olfactory bulb (2021)

During adult rodent life, newborn neurons are added to the olfactory bulb (OB) in a tightly controlled manner. Upon arrival in the OB, input synapses from the local bulbar network and the higher olfactory cortex precede the formation of functional output synapses, indicating a possible role for these regions in newborn neuron survival. An interplay between the environment and the piriform cortex in the regulation of newborn neuron survival has been suggested. However, the specific network and the neuronal cell types responsible for this effect have not been elucidated. Furthermore, the role of the other olfactory cortical areas in this process is not known. Here we demonstrate that pyramidal neurons in the mouse anterior olfactory nucleus, the first cortical area for odor processing, have a key role in the survival of newborn neurons. Using DREADD (Designer Receptors Exclusively Activated by Designer Drugs) technology, we applied chronic stimulation to the anterior olfactory nucleus and observed a decrease in newborn neurons in the OB through induction of apoptosis. These findings provide further insight into the network regulating neuronal survival in adult neurogenesis and strengthen the importance of the surrounding network for sustained integration of new neurons.
TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells during Beryllium Sensitization (2018)

Metal-induced hypersensitivity is driven by dendritic cells (DCs) that migrate from the site of exposure to the lymph nodes, upregulate costimulatory molecules, and initiate metal-specific CD4<sup>+</sup> T cell responses. Chronic beryllium disease (CBD), a life-threatening metal-induced hypersensitivity, is driven by beryllium-specific CD4<sup>+</sup> Th1 cells that expand in the lung-draining lymph nodes (LDLNs) after beryllium exposure (sensitization phase) and are recruited back to the lung, where they orchestrate granulomatous lung disease (elicitation phase). To understand more about how beryllium exposures impact DC function during sensitization, we examined the early events in the lung and LDLNs after pulmonary exposure to different physiochemical forms of beryllium. Exposure to soluble or crystalline forms of beryllium induced alveolar macrophage death/release of IL-1α and DNA, enhanced migration of CD80<sup>hi</sup> DCs to the LDLNs, and sensitized HLA-DP2 transgenic mice after single low-dose exposures, whereas exposures to insoluble particulate forms beryllium did not. IL-1α and DNA released by alveolar macrophages upregulated CD80 on immature BMDC via IL-1R1 and TLR9, respectively. Intrapulmonary exposure of mice to IL-1R and TLR9 agonists without beryllium was sufficient to drive accumulation of CD80<sup>hi</sup> DCs in the LDLNs, whereas blocking both pathways prevented accumulation of CD80<sup>hi</sup> DCs in the LDLNs of beryllium-exposed mice. Thus, in contrast to particulate forms of beryllium, which are poor sensitizers, soluble or crystalline forms of beryllium promote death of alveolar macrophages and their release of IL-1α and DNA, which act as damage-associated molecular pattern molecules to enhance DC function during beryllium sensitization.
Bariatric Orthopaedics: Total Hip Arthroplasty in Super-Obese Patients (Those with a BMI of ≥50 kg/m2) (2016)

The clinical and patient-reported outcomes of primary total hip arthroplasty were lower in the super-obese patients. These patients also faced challenges in finding surgeons who would perform their procedure. Super-obese patients may benefit from counseling with their treating surgeon to set realistic expectations with regard to the outcomes of their procedure.
Genome sequence of the hot pepper provides insights into the evolution of pungency in Capsicum species (2014)

Hot pepper (Capsicum annuum), one of the oldest domesticated crops in the Americas, is the most widely grown spice crop in the world. We report whole-genome sequencing and assembly of the hot pepper (Mexican landrace of Capsicum annuum cv. CM334) at 186.6× coverage. We also report resequencing of two cultivated peppers and de novo sequencing of the wild species Capsicum chinense. The genome size of the hot pepper was approximately fourfold larger than that of its close relative tomato, and the genome showed an accumulation of Gypsy and Caulimoviridae family elements. Integrative genomic and transcriptomic analyses suggested that change in gene expression and neofunctionalization of capsaicin synthase have shaped capsaicinoid biosynthesis. We found differential molecular patterns of ripening regulators and ethylene synthesis in hot pepper and tomato. The reference genome will serve as a platform for improving the nutritional and medicinal values of Capsicum species.
The Validator tool suite: filling the gap between conventional soft- ware-in-the-loop and hardware-in-the-loop simulation environments (2011)

Software-In-the-Loop (SIL) and Hardware-In-the-Loop (HIL) simulation environments represent established methods and tools for testing real-time embedded systems before they are deployed in products. Nevertheless, some key features that we regard as crucial for improving the quality of embedded systems are missing in both conventional SIL and HIL approaches. What we have called the Validator, a cutting-edge simulation environment for verification and validation, fills that gap. The Validator offers the advantages of SIL simulations in terms of cost and simulation speed as well as the advantages of HIL simulations in terms of accuracy. The new key feature of the Validator is advanced debugging of embedded systems that deals with timing behavior as if the software would be executed on a target platform. The Validator also offers regression testing at a level of granularity that leads to a solid comparison between several versions of a system, for example, a legacy system and its reengineered or enhanced artefact. The Validator was applied to large industrial legacy systems for simulating the computational part in closed-loop with continuous-time plant models in MATLAB ® /Simulink ® . For that purpose, the Validator allows co-simulation with other simulation tools based on time synchronization protocols. This chapter
Switchable organic electroluminescence (2002)

The vacuum deposited amorphous organic thin film melamine cyanurate (MC) is found to possess an electrical switching property. The as-fabricated fresh thin film is at a semiconductor state and shows a rectification property in a range of several voltages. Under a higher applied voltage, the resistance of the film changes to a lower value, and shows linearity in its current–voltage relationship. After the application of a negative driving voltage for no more than 100 s, the MC film returns from the resistor state to the semiconductor state with a higher impedance. Based on this reproducible switching phenomenon, a type of voltage-controlled switchable organic electroluminescence device was fabricated by inserting the MC layer between the anode indium tin oxide (ITO) and the hole transport layer N,N′-bis (3-methylphenyl)-N,N′-diphenyl-benzidine (TPD). In the forward driving voltage scan (for example, increasing the driving voltage from 0 to 16 V), the impedance is higher and the current density is lower; then the scan is backward (decreasing the driving voltage from 16 to 0 V), the impedance becomes lower and the current density becomes higher. Corresponding to the two different current density states at the same driving voltage, the device luminance also reaches two different states, one is lower and another is higher. This transition from a high (ON) to low luminance (OFF) renders a prototype to realize a switchable organic electroluminescence.
Supplementary Movie S1. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity (2023)

&lt;p&gt;Typical actin cytoskeleton organization observed in most NK cell-conjugated MDA-MB-231 cells. The cell conjugate was acquired on a LSM880 laser scanning confocal microscope (Carl Zeiss) with Airyscan in the high-resolution mode, and the 3D projection was assembled and animated using Zeiss Zen Software. Then NK cell was stained in red (PKH26) whereas the LifeAct-mEGFP-expressing tumour cell appears in green.&lt;/p&gt;
On the Impact of Human and Organizational Archetypes on Human Failure Probabilities Used in Risk Analyses (2013)

In a previous paper a radar diagram showing the influence of a set of ten features has been presented, discussed and their influence on human failure probabilities has been assessed. Among these, the most important features were management of change, control center design, and training. In this paper, we discuss the use of organizational archetypes in process plants in order to estimate human failure probabilities more realistically by bringing safety culture into stage. The analysis of archetypes is justified not only for the Tokaimura plant, as discussed in this paper, but also for most organizations, where safety efforts are credited to design, and safety restrictions accomplishment during operation is not trivial, even for those organizations with good safety standards. Generally, inadequate cost, schedule, and performance considerations lead to consequences with greater impact on deviations and incidents. The archetype analysis presented considers nonlinear interactions of factors that influence the maintenance of safety level. It produces good indicators of safety management plan improving during operation. This analysis becomes a relevant tool for facilities where safety culture is not strong.
Regulatory T Cell–Resistant CD8+ T Cells Induced by Glucocorticoid-Induced Tumor Necrosis Factor Receptor Signaling (2008)

We previously found that a Salmonella typhimurium vector engineered to secrete soluble tumor antigen induces CD4(+) T cells resistant to CD4(+)CD25(+) regulatory T cells (Treg) and that glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR) signal is involved in the development of this resistance. In this study, we address the potential of incorporating GITR ligand (GITRL) as a way to augment the immunogenicity of cancer vaccines. BALB/c mice were immunized by gene gun with plasmids encoding the mutated extracellular signal-regulated kinase 2 (mERK) with or without plasmids encoding mouse GITRL. Coadministration with GITRL during primary and secondary immunization enhanced the induction of mERK-specific CD8(+) T cells. Antibody depletion and minigene analysis suggested that GITRL directly activated CTL epitope-specific CD8(+) T cells independently of CD4(+) T cells. Immunization with plasmids encoding a CTL epitope and GITRL resulted in strong tumor inhibition in a CD8(+) T cell-dependent manner. Furthermore, CTL epitope-specific CD8(+) T cells induced by immunization with plasmids encoding CTL epitope coadministered with GITRL were refractory to suppression by CD4(+)CD25(+) Tregs compared with CD8(+) T cells induced without GITR signaling. We propose that coadministration of GITR signaling agents with tumor antigens constitutes a promising novel strategy for cancer vaccine development.
Bidirectional Interactive Contents Player for Terrestrial Digital Multimedia Broadcasting (2008)

This paper presents a bidirectional interactive contents player for terrestrial digital multimedia broadcasting (T-DMB). The presented player is capable of sending user requests to a proper return channel server using information included in a scene presentation. The player provides functionality to combine requested data received via communication networks with the initially broadcasted contents to present additional information to users. The result of a request transmitted back through the broadcasting network can also be presented properly using the presented player.
Giant enhancement of spectral emissions from molecules adsorbed on fractal/microcavity composite media (2002)

We describe the characteristics of a novel optical material developed in our laboratory, a fractal/microcavity composite. Both components of this composite exhibit resonance behavior whereby the amplitudes of spectral emissions, generated by molecules either adsorbed onto the composite or located remotely from it, are significantly enhanced. In the composite, the individual enhancement factors combine multiplicatively with the result that spectral emissions are enhanced by an extremely large factor. In particular, the extremely large enhancement factors facilitate the generation of nonlinear optical processes in the composite, which may be exploited in the fabrication of ultra-sensitive detectors.
Catheter ablation of premature ventricular contractions originating from periprosthetic aortic valve regions (2020)

PVCs arising from PPAV regions can be successfully ablated in patients with prior AVR, without damaging the prosthetic aortic valve and atrioventricular conduction.
Proceedings of the fourth workshop on Analytics for noisy unstructured text data (2010)

Thank you for attending AND 2010! Fourth workshop in the AND series contains highquality work spanning a large array of disciplines related to the treatment of Noisy text. This year AND is collocated with CIKM so the flavor of IR and KM shows through in the AND program as well.

The final program consists of 11 papers selected from 21 submissions. Each paper was carefully reviewed by three Program Committee members. We would like to thank our Program Committee for selecting this high-quality program for AND 2010.

Papers in which a student is the primary author (first author/presenter) will be eligible for the IAPR Best Student Paper Award. initial short listing for this award has been done based on the reviews. final decision will be made during the workshop based on the presentations.

Also the best papers from the workshop will appear in a special issue of the International Journal on Document Analysis and Recognition after going through further reviewing. selection for this is based on the reviews of the AND PC members.

We are excited to have Randy Geobel, University of Alberta, Canada, as the key note speaker. His talk is very interestingly titled The nature of noise in linguistic corpora.