gebhart/patrepeval huggingface dataset:
Table S4 from Inhibition of BET Bromodomain Proteins with GS-5829 and GS-626510 in Uterine Serous Carcinoma, a Biologically Aggressive Variant of Endometrial Cancer (2023)

&lt;p&gt;Average quantitative nuclear histological score associated with the ex vivo c-Myc expression assessed by IHC in the ARK2 xenograft tumor samples, excised 1 hour and 6 hours after a single dose of GS-5829 at 40, 20, 10 mg/kg, GS-626510 at 10 mg/kg and vehicle for oral gavage studies.&lt;/p&gt;
Supplementary Table 2 from A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma (2023)

&lt;p&gt;XLS file - 65K, Interaction indicies of MEK inhibitor GSK1120212, AKT inhibitor GSK690693 in PDA cell lines&lt;/p&gt;
Teaching and physics education research: bridging the gap (2014)

Physics faculty, experts in evidence-based research, often rely on anecdotal experience to guide their teaching practices. Adoption of research-based instructional strategies is surprisingly low, despite the large body of physics education research (PER) and strong dissemination effort of PER researchers and innovators. Evidence-based PER has validated specific non-traditional teaching practices, but many faculty raise valuable concerns toward their applicability. We address these concerns and identify future studies required to overcome the gap between research and practice.
2009 CSREES National Water Conference; St. Louis, MO Surfactant Modification of Water Repellent Soils and Consequences to Rootzone Water and Apple Productivity (2009)

Soil water repellency (SWR) is a well known phenomenon impacting Australian soils, yet studies evaluating the consequences of SWR on yield and quality are conspicuously absent. With the recent impacts of drought on water quantity in the Murray-Darling basin, the projected impacts of climate change, and the expansion of production of high value orchard crops, the sustainability of production requires development of novel strategies to optimize the efficient delivery and use of water. Recently discovered synergistic co-formulations of alkyl polyglycoside and ethylene oxide-propylene oxide (EO/PO) block copolymer surfactants have accelerated research on the effects of surfactants on wetting of water repellent soils. The objective of this study was to determine 1) the effect of surfactant treatment on soil water content and wetting front depth in mini-sprinkler irrigated, water repellent, Goulburn Valley clay loam soils and 2) the consequence of SWR remediation on yield of Malus domestica Borkh. Variety Pink Lady in 2006/07 and variety Gala in 2007/08. Soil surfactant was applied at the initial rates of 0, 5 and 10 L haP-1P in November of each year, then at 0, 2.5 and 5 L haP-1P respectively at monthly intervals through March, 2007 or January, 2008. Surfactant treatment significantly increased wetting front depth and soil volumetric water content at 10cm or 20 cm. Surfactant treatments increased total
Influence of calcite on uranium(VI) sorption onto montmorillonite clay (2019)

International audience
Adolescent Perinatal Outcomes in South West Sydney, Australia (2018)

Adolescents have birth outcomes to similar to those of their older counterparts. Adolescents had lower booking blood pressures. This may have implications for the screening and diagnosis of hypertensive disorders of pregnancy in adolescents.
ISI Mitigation Capability of MLSE Direct-Detection Receivers (2008)

We explain why maximum-likelihood sequence estimation (MLSE) receivers for direct-detection optical communication systems do not achieve the single-pulse performance of threshold receivers, in which there is no intersymbol interference (ISI). For this purpose, we propose a simple and intuitive model to approximate the performance of MLSE receivers under the assumption of moderate ISI. A performance analysis of this model shows that an MLSE receiver does not reach the performance of an ISI-free threshold receiver. By simulations we evaluate the range over which the model accurately approximates the MLSE receiver.
Nonlinear silicon photonics (2011)

We demonstrate a wide range of devices based on four-wave mixing in Silicon nanostructures that offer the potential for ultrahigh bandwidth all-optical processing, slow light, and CMOS-compatible multiple-wavelength sources.
Development of pumps for pulse compression laser applications. Final report, 15 June 1976--15 December 1977 (1978)

The report describes an effort aimed at developing a more efficient flash-lamp for pumping blue laser dyes. The work was supported by the Navy as part of their program to develop laser sources which operate in the blue-green transmission band of sea water. The effort was based on the possible use of mercury lamps of the high pressure capillary type (AH6), with and without spectral additives. A wide range of operating conditions were explored. Those found most suitable for pumping Rh6G gave no better performance than xenon lamps, and tests designed to evaluate their use for pumping blue laser dyes also showed no evidence of improved performance. Additives for the spectrally enhanced lamps were chosen by means of a computer program. In general, the spectra of the additives conformed in a general way to those predicted by the program. However, operating difficulties primarily arising from lamp instabilities, precluded the useful application of these additives. An alternative approach, based on molecular radiators, is proposed.
Collaborative defense as a pervasive service Architectural insights and validation methodologies of a trial deployment (2009)

Network defense is an elusive art. The arsenal to defend our devices from attack is constantly lagging behind the latest methods used by attackers to break into them and subsequently into our networks. To counteract this trend, we developed a distributed, scalable approach that harnesses the power of collaborative end-host detectors or sensors. Simulation results reveal order of magnitude improvements over stand-alone detectors in the accuracy of detection (fewer false alarms) and in the quality of detection (the ability to capture stealthy anomalies that would otherwise go undetected). Although these results arise out of a proof of concept in the arena of botnet detection in an enterprise network, they have broader applicability to the area of network self-manageability of pervasive computing devices. To test the efficacy of these ideas further, Intel Corporation partnered with British Telecommunications plc to launch a trial deployment. In this paper, we report on results and insights gleaned from the development of a testbed infrastructure and phased experiments; (1) the design of a re-usable measurement-inference architecture into which 3rd party sensor developers can integrate a wide variety of ldquoanomaly detectionrdquo algorithms to derive the same correlation-related performance benefits; (2) the development of a series of validation methodologies necessitated by the lack of mature tools and approaches to attest to the security of distributed networked systems; (3) the critical role of learning and adaptation algorithms to calibrate a fully-distributed architecture of varied devices in varied contexts, and (4) the utility of large-scale data collections to assess what's normal behavior for Enterprise end-host background traffic as well as malware command-and-control protocols. Finally, we propose collaborative defense as a blueprint for emergent collaborative systems and its measurement-everywhere approach as the adaptive underpinnings needed for pervasive services.
ChemInform Abstract: Rhodium‐Catalyzed 1,4‐Addition Reactions of Diboron Reagents to Electron‐Deficient Olefins. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An Enzymatic Chemical Amplifier Based on Mechanized Nanoparticles (2013)

A chemical amplifier was constructed based on enzyme-encapsulated mesoporous silica nanoparticles. By employing a supramolecular nanogate assembly that is capable of controlling the access to the encapsulated enzyme, selectivity toward substrate sizes is enabled. When an analyte molecule actuates the mechanical nanogate and exposes the enzymes, a catalytic production of fluorescent molecules is initiated. This study demonstrates a new concept of self-amplification of a chemical sensing process and can potentially increase the detection sensitivity.
Vectofusin-1 Promotes RD114-TR-Pseudotyped Lentiviral Vector Transduction of Human HSPCs and T Lymphocytes (2017)

Ex vivo transduction of human CD34<sup>+</sup> hematopoietic stem/progenitor cells (hCD34<sup>+</sup> HSPCs) and T lymphocytes is a key process that requires high efficiency and low toxicity to achieve effective clinical results. So far, several enhancers have been used to improve this process. Among them, Retronectin highly meliorates VSV-G and RD114-TR pseudotyped lentiviral vector delivery in hCD34<sup>+</sup> HSPCs and T lymphocytes. However, Retronectin is expensive and requires pre-coating of culture dishes or bags before cell seeding, resulting in a cumbersome procedure. Recently, an alternative transduction adjuvant has been developed, named Vectofusin-1, whose effect has been demonstrated on gene delivery to cell lines and primary hCD34<sup>+</sup> HSPCs by lentiviral vectors pseudotyped with different envelope glycoproteins. In this study, we have focused our analysis on the effect of Vectofusin-1 on the transduction of hCD34<sup>+</sup> HSPCs and T lymphocytes by using mostly RD114-TR pseudotyped lentivectors and clinical transduction protocols. Here, we have proved that Vectofusin-1 reproducibly enhances gene delivery to hCD34<sup>+</sup> HSPCs and activated T cells without cell toxicity and with efficacy comparable to that of Retronectin. The use of Vectofusin-1 will therefore help to shorten and simplify clinical cell manipulation, especially if automated systems are planned for transducing large-scale clinical lots.
Fiber-optic true-time-delay control of an array antenna (1995)

We present a sparsely-populated-array transmitter antenna controlled by a true-time-delay fiber-optic beam former. The beam former is based on a novel technique1 that does not suffer from the specialized component requirements, power losses, or instabilities of previous techniques.2-4 The antenna has a 2-12-GHz instantaneous bandwidth and shows a &gt;100° squint-free azimuth-steering characteristic.
A thin film phantom for blood flow simulation and Doppler test (2001)

The thin film phantom is a new type of ultrasound resolution test object. It consists of a thin planar substrate that is acoustically matched to the surrounding media. Precisely located scatterers on the surface of the substrate generate echo signals. The patterning of scatterers on the substrate allows echogenicity to be controlled as a function of position, which enables the production of a test object with highly reproducible and controllable scattering characteristics. We show that by vibrating the substrate in a suitable manner, an echo signal may be generated that simulates bi-directional flow. We demonstrate that a vibration of low amplitude at frequency f0 produces a Doppler spectral signal at f0 and -f0, within the limits of aliasing. Furthermore, by driving the film with a bandlimited noise signal, we illustrate how a velocity distribution may be simulated. A time-varying flow velocity may be simulated by varying the noise bandwidth with time. Finally, using this technique, we demonstrate a system that simulates an arterial flow pattern, including its characteristic velocity distribution in forward and reverse directions simultaneously.
Synthesis of methoxy and hydroxy analogs of 1,2,3,4,4a,9a-hexahydro-4a-fluorenamine: rigid phencyclidine analogs as probes of phencyclidine binding site topography (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of methoxy and hydroxy analogs of 1,2,3,4,4a,9a-hexahydro-4a-fluorenamine: rigid phencyclidine analogs as probes of phencyclidine binding site topographyYuan Ping Pang and Alan P. KozikowskiCite this: J. Org. Chem. 1991, 56, 14, 4499–4508Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/jo00014a033https://doi.org/10.1021/jo00014a033research-articleACS PublicationsRequest reuse permissionsArticle Views776Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Cross-priming of cyclin B1, MUC-1 and survivin-specific CD8+T cells by dendritic cells loaded with killed allogeneic breast cancer cells (2006)

This ability of DCs loaded with killed allogeneic breast cancer cells to elicit multiantigen specific immunity supports their use as vaccines in patients with breast cancer.
Thermal endurance of high temperature fiber reinforced cellulose insulation [for transformers] (2001)

Advancements have been made in the thermal endurance of cellulose-based insulating papers by reinforcing the cellulose matrix with a high temperature synthetic fiber. This new insulating material is made by adding synthetic fibers to the cellulose pulp along with a binder material that bonds the synthetic fiber into the cellulose matrix. The high temperature fibers form a reinforcing backbone that gives the paper mechanical integrity, even after the cellulose component has thermally degraded. The authors describe how this new material has been used to improve the thermal durability of liquid-filled power transformers.
Periostin promotes malignant potential by induction of epithelial‐mesenchymal transition in intrahepatic cholangiocarcinoma (2017)

Periostin, a secreted matricellular protein, has been reported to induce epithelial-mesenchymal transition (EMT), which increases motility and invasiveness in various epithelial cancer cells. Periostin is also overexpressed in intrahepatic cholangiocarcinoma (ICC) and suggested to be a biomarker for tumor progression and poor prognosis; however, its functional role in ICC is not fully understood. Here, we investigated whether periostin influences malignant potential through the induction of EMT in ICC. Analyses of surgical resected ICC specimens revealed that the gene expression of periostin was significantly higher in ICC tumors than in adjacent nontumor liver tissues and was closely correlated with the expression of mesenchymal markers, including N-cadherin, vimentin, and fibronectin. However, the expression level of periostin varied in each case. Consistently, the expression of periostin in HuH28 (an undifferentiated ICC cell) was markedly higher than in HuCCT-1 (a moderately differentiated ICC cell). In addition, high-level secretion of periostin into culture media was observed in HuH28 but not in HuCCT-1. To identify the biological significance of periostin in EMT, gene silencing of periostin by small interfering RNA was performed in HuH28 cells. Periostin knockdown in HuH28 cells significantly down-regulated mesenchymal markers and up-regulated epithelial markers, suggesting the reversal of EMT, namely mesenchymal-epithelial transition. Along with these changes, cell proliferation was significantly suppressed by 52%. In addition, cell migration and invasion were significantly suppressed by 62% and 61%, respectively, with reduced gene expression of matrix metalloproteinase 2. Interestingly, chemosensitivity to gemcitabine was also significantly improved by periostin depletion. <i>Conclusion:</i> Periostin plays an important role in the regulation of malignant potential through EMT and is suggested to be a novel target for the treatment of ICC. (<i>Hepatology Communications</i> 2017;1:1099-1109).
Temperature‐Dependent Photonic Bandgap in a Self‐Assembled Hydrogen‐Bonded Liquid‐Crystalline Diblock Copolymer (2002)

Abstract We take advantage of self‐assembly in a hierarchically structured, hybrid material to develop photonic bandgaps in the visible which may be systematically tuned by application of thermal or electric fields. Hydrogen bonding between a host polymer and a guest small molecule is used to augment the molecular weight of an appropriately selected coil–coil diblock copolymer to bring the microdomain structure onto the length scale needed for significant interaction with visible light. Further, the use of liquid‐crystal‐mesophase‐forming moieties as the guest hydrogen‐bonding units adds functionality to the system as the optical properties of the liquid‐crystalline domains can be modulated by external stimuli. We use hydrogen bonding to sequester varying amounts of imidazole terminated mesogens within the acid domains of a poly[styrene‐ block ‐poly‐(methacrylic acid)] (PS‐ b ‐MAA) diblock copolymer. The resulting PS‐ b ‐MAA/LC side‐group liquid‐crystalline diblock copolymer possesses a photonic bandgap in the green with the exact location and structure of the gap dependent on the composition of the system. Here, we discuss the structure and optical properties of these materials as a function of their composition and the response of the optical properties to temperature. Varying the order parameter of the LC domains by heating into the isotropic state changes the peak reflectivity by 40 nm, resulting in a color change from green to orange.
[Systemic administration of antibiotics in therapy of brain abscesses. Present trends and possibilities]. (1993)

The authors describe possibilities as regards selection of antibiotics in the general treatment of brain abscesses. They mention the most frequent aetiological agents of the disease in relation to predisposing factors and site. Systemic antibiotherapy along with surgery is considered by the authors decisive in the therapy of these conditions.
Effective medium theories in surface enhanced infrared spectroscopy: The pentacene example (2002)

Effective medium theory (EMT) is a semiempirical approach developed to predict the response properties of composites. In particular, EMT has been applied to the study of rough metal surfaces that can enhance the absorption of electromagnetic radiation in the infrared [surface-enhanced infrared absorption (SEIRA) or in the visible (surface-enhanced visible]. The application of EMT provides a formalism to simulate the effective dielectric function of the inhomogeneous medium, for instance, of metal-organic thin films. The EMT is widely applied when the dimensions of the inhomogeneties (granular components in the mixed film) are smaller than the wavelength of the incident radiation. The computational approach to SEIRA using EMT, and the experimental SEIRA results for pentacene are presented here. First, enhancement factors are calculated using EMT method for pentacene on Ag, Cu, and Sn. Vibrational intensities for each symmetry species are obtained using DFT B3LYP at the 6-31G(d) level of theory. Second, from the set of experimental data provided by reflection- absorption infrared (RAIRS) and transmission FT-IR spectra of a 15 nm pentacene film evaporated onto reflecting and IR transparent support substrates, respectively, the molecular orientation and the interpretation of the observed spectra in conformity with the surface selection rules was extracted. The interpretation of the pentacene SEIRA spectra of a 15 nm pentacene film on silver and tin islands is presented and its compliance with surface selection rules is discussed.
Water Quality Model Calibration by Means of Fast Messy Genetic Algorithm (2005)

A water quality model is to predict water quality transport and fate throughout a water distribution system. The model is not only a promising alternative for analyzing disinfectant residuals in a cost-effective manner, but also a means of providing enormous engineering insights into the characteristics of water quality variation and constituent reactions. However, a water quality model is a reliable tool only if it predicts what a real system behaves. This paper presents a methodology based upon fast messy genetic algorithm that enables a modeler to efficiently calibrate a water quality model such that the field observed water quality values match with the model simulated values. The approach is integrated with a well-developed hydraulic and water quality modeling system. It provides a generic tool for engineers to construct the sound water quality model in expedient manner. The method is applied to a water system and demonstrated that a water quality model can be effectively calibrated for managing adequate water supply for water utilities.
A COMPARISON OF ENERGY EXPENDITURE REQUIRED TO PROPEL TWO TYPES OF WHEELCHAIR DRIVES. (2003)

Swisher, A; Swisher, K; Bonner, D; Bullock, M; Gensler, A; Weaver, L; Martin, R; Long, T; Stiller, A Author Information
PYROLYSIS OF WASTE ELECTRICAL AND ELECTRONIC EQUIPMENT (WEEE) FOR RECOVERING METALS AND ENERGY: PREVIOUS ACHIEVEMENTS AND CURRENT APPROACHES (2015)

The amount of collected Waste Electrical and Electronic Equipment (WEEE) in Europe is growing about 7 wt.-% per year (2007)(2008)(2009)(2010)(2011)(2012).It contains a number of economically relevant base, precious and high-tech metals.However, only a limited number of these metals can be recovered by currently applied recycling processes.Especially high-tech metals like gallium, germanium and tantalum get lost during the treatment of WEEE.The pyrolysis technology allows an accumulation of these metals from WEEEfractions without oxidation as well as the generation of high calorific gases and liquids for energetic utilization.This paper provides a literature based review of lab and medium-scale investigations on pyrolysis processes of different WEEE-fractions like printed wiring boards (PWB) or plastics to outline opportunities and challenges for recovering critical metals from WEEE via pyrolysis.The key procedural challenges are dehalogenation, avoidance of highly-toxic emissions (mainly PBDD/F) as well as preparation and accumulation of metals for recycling processes.
Grafting mechanism and olefin metathesis activity of well-defined silica-supported Mo imido alkyl alkylidene complexes (2007)

Grafting of [Mo(NAr)( CHCMe 2 R)(CH 2 tBu) 2 ], 1 - R (R = Me or Ph) on the surface silanols of SiO 2-(700) gives 2 - R through the electrophilic cleavage of the Mo–C σ-bond according to labelling (GC/MS and solid-state NMR) and reactivity studies (monitoring initiation). Similarly, molecular silanol derivatives react with 1 - Ph also to give directly the monosiloxy derivatives. Therefore, surface or molecular silanols have reactivities similar to alcohols and phenols having p K a ≥ 9. Finally, the surface complex 2 - R (R = Me or Ph) is a highly efficient olefin metathesis catalyst.
Short‐term treatment with the GABAA receptor antagonist pentylenetetrazole produces a sustained pro‐cognitive benefit in a mouse model of Down's syndrome (2013)

Low doses of pentylenetetrazole were safe, produced long-lasting cognitive improvements and have the potential of fulfilling an unmet therapeutic need in Down's syndrome.