gebhart/patrepeval huggingface dataset:
Synthesis and Luminescence of Soluble meso-Unsubstituted Tetrabenzo- and Tetranaphtho[2,3]porphyrins (2005)

[Structure: see text]. Syntheses of soluble tetrabenzoporphyrins (TBP) and tetranaphtho[2,3]porphyrins (TNP), with multiple substituents in the conjugated aromatic rings but bearing no substituents in the meso-positions, is reported. Both types of porphyrins were obtained by direct aromatization of precursor porphyrins, annealed with either cyclohexene or dihydronaphthalene fragments. TBPs and TNPs possess powerful absorption bands in the near-infrared (lambda = 610-710 nm, epsilon = 100,000-300,000 M(-1) cm(-1)) and exhibit strong luminescence. Free bases and Zn complexes fluoresce with quantum yields of up to 50%, whereas Pd and Pt complexes phosphoresce in solutions at ambient temperatures. Remarkably, the phosphorescence quantum yields of Pd and Pt TBPs reach as high as 20-50%, which places them among the brightest near-infrared phosphors known to date.
A dramatic solvent effect during aromatic halogen-metal exchanges. Different products from lithiation of polyfluorobromobenzenes in ether and tetrahydrofuran (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA dramatic solvent effect during aromatic halogen-metal exchanges. Different products from lithiation of polyfluorobromobenzenes in ether and tetrahydrofuranAlexander J. Bridges, William C. Patt, and Thomas M. StickneyCite this: J. Org. Chem. 1990, 55, 2, 773–775Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/jo00289a069https://doi.org/10.1021/jo00289a069research-articleACS PublicationsRequest reuse permissionsArticle Views683Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparison of Tripolar and Circular Pads for IPT Charging Systems (2017)

Recently, a magnetic pad called the tripolar pad (TPP) has been introduced for inductive power transfer (IPT) systems. This paper evaluates the effective coupling factor and leakage magnetic field of a 20-kW IPT system that uses a combination of TPP and circular pad (CP) topologies over a range of lateral displacements. The results show that the effective coupling factor and the leakage magnetic field of the TPP-TPP system are substantially better when the secondary is displaced away from ideal alignment. Leakage magnetic field is reduced up to 43% compared to the CP-CP system at the worst-case misalignment, which is due to the ability of the TPP-TPP system to generate and capture different types of magnetic field shapes. Simulation methods for both the TPP and CP are validated in the laboratory using a 2-kW system operating at 85 kHz.
Quadratic Electrooptic Effect for Frequency Down-Conversion (2010)

A novel optical frequency down-conversion approach employing the quadratic electrooptic effect is proposed, analyzed, and verified. This down-conversion method can seamlessly integrate with an optical phase-locked-loop linear phase demodulator. It has the potential to achieve a large dynamic range and low conversion loss. Comprehensive theoretical studies are performed to investigate the noise, efficiency, and linearity of this down-conversion approach. Experiments are then conducted. It is found that the unwanted fourth-order electrooptic effect of the InP modulator device limits the dynamic range.
Adalimumab Safety in Crohnʼs Disease Patients: Open-Label Maintenance Following the Gain and CHARM Trials (2007)

Purpose: Adalimumab (ADA) is approved for the induction and maintenance of remission in adults with moderate to severe Crohn's disease (CD) and has demonstrated efficacy and safety in patients with and without prior anti-TNF experience.[1–3] Methods: We assessed the safety of ADA maintenance therapy in patients who completed either of two Phase III, double-blind, placebo-controlled, adalimumab safety and efficacy trials, GAIN (4-week induction in infliximab failures) and CHARM (1-year maintenance). Patients had active CD (CDAI 220–450) and included those naïve to prior anti-TNF therapy (approximately 50% of 854 patients in CHARM) or who had lost response to/were intolerant of prior infliximab therapy (GAIN). Safety was routinely assessed throughout the Phase III trials and the open-label extension (OLE). Adverse events (AE) were tabulated in events/100-patient-years (E/100 PY) through 1 year in the OLE (combined data, representing 1 year since the start of GAIN and 2 years since the start of CHARM). Results: Of 1169 patients, all had received ADA in either GAIN (N = 315) or CHARM (N = 854) [including during the OLE]. Adverse events of interest are listed (table). Non-systemic candidiasis comprised 27 of the 28 opportunistic infection AEs, with 1 case of coccidiodomycosis. Of the 21 malignant AEs, 11 were skin cancers and 1 was a lymphoma; the remainder were widely scattered.Table: Events of Interest: GAIN/CHARM combined (N = 1,169; 1,299 PY)Conclusion: Adalimumab has proven to be well-tolerated in the treatment of Crohn's disease after the 1-year follow up of patients from GAIN, and the 2-year follow up of patients from CHARM. This Crohn's disease adalimumab safety profile is consistent with the profiles in the original studies, as well as with the safety profile from other adalimumab indications. 1. Sandborn WJ, et al. Ann Intern Med. 2007;146(12):829–838. 2. Colombel JF, et al. Gastroenterology. 2007;132:52–65. 3. Schiff MA, et al. Ann Rheum Dis. 2006;65:889–894.
11.1: A 4‐mm Radius Curved Display with Touch Screen (2014)

Abstract We discuss the steps for obtaining a curved touch‐enabled display by using a c‐axis aligned crystalline oxide semiconductor, OLEDs, a flexible‐display technology, and a capacitive touch screen. This result is a side‐roll display in which the front and side surfaces are a single curved surface with a 4 mm radius.
Noun sense induction using web search results (2005)

This paper presents an algorithm for unsupervised noun sense induction, based on clustering of Web search results. The algorithm does not utilize labeled training instances or any other external knowledge source. Preliminary results on a small dataset show that this technique provides two advantages over other techniques in the literature: it detects real-world senses not found in dictionaries or other lexical resources, and it does not require that the number of word senses be specified in advance.
Size-controlled InGaN/GaN nanorod array fabrication and optical characterization (2013)

We demonstrate a cost-effective top-down approach for fabricating InGaN/GaN nanorod arrays using a wet treatment process in a KOH solution. The average diameter of the as-etched nanorods was effectively reduced from 420 nm to 180 nm. The spatial strain distribution was then investigated by measuring the high-resolution cathodoluminescence directly on top of the nanorods. The smaller nanorods showed a higher internal quantum efficiency and lower potential fluctuation, which can subsequently be exploited for high-efficiency photonic devices.
THE EFFECT OF BALLOON INFLATION AND SPINAL EXTENSION ON RESTORING GEOMETRIC AND LOADING ALIGNMENT OF THE VERTEBRAL COMPRESSION FRACTURE (2006)

Purpose: The purpose of this biomechanical study was to assess: (1) the effect of thoracic vertebral compression fracture (VCF) on kyphosis and physiologic compressive load path, and (2) the effect of balloon kyphoplasty and spinal extension on restoration of normal geometric and loading alignment. Methods: Six fresh human thoracic specimens, each consisting of three adjacent vertebrae were used. In order to create a VCF, IBTs were placed transpedicularly into the middle VB and cancellous bone was disrupted by inflation of IBTs. After cancellous bone disruption the specimens were compressed using bilateral loading cables until a fracture was observed. Fracture reduction by spinal extension, and then by balloon kyphoplasty was performed under a physiologic compressive preload of 250 N. The vertebral body heights, kyphotic deformity, and location of compressive load path were measured on video-fluoroscopy images. Results: The VCF caused anterior VB height loss of 3715%, middle-height loss of 3416%, segmental kyphosis increase of 147.0 degrees, and vertebral kyphosis increase of 135.5 degrees (p Conclusions: An anterior shift of the compressive load path in VBs adjacent to VCF can induce additional flexion moments. The eccentric loading may contribute to the increased risk of new VB fractures adjacent to an uncorrected VCF deformity. Extension moment could fully correct the segmental kyphosis but could not restore the middle height of the fractured vertebral body. Balloon kyphoplasty reduced the VCF deformity and partially restored the compressive load path to normal alignment.
Power Guarantee for Electric Systems Using Real-Time Scheduling (2020)

Modern electric systems, such as electric vehicles, mobile robots, nano satellites, and drones, require to support various power-demand operations for user applications and system maintenance. This, in turn, calls for advanced power management that jointly considers power demand by the operations and power supply from various sources, such as batteries, solar panels, and supercapacitors. In this article, we develop a power scheduling framework for a reliable energy storage system with multiple power-supply sources and multiple power-demand operations. Specifically, we develop offline power-supply guarantee analysis and online power management. The former provides an offline power-supply guarantee such that every power-demand operation completes its execution in time while the sum of power required by individual operations does not exceed the total power supplied by the entire energy storage system at any time; to this end, we develop a plain power-supply analysis as well as its improved version using real-time scheduling techniques. On the other hand, the latter efficiently utilizes the surplus power available at runtime for improving system performance; we propose two approaches, depending on whether future scheduling information of power-demanding tasks is available or not. For evaluation, we perform simulations to evaluate both the plain and improved analyses for offline power guarantee under various synthetic power-demand operations. In addition, we have built a simulation model and demonstrated that the proposed framework with the offline analysis and online management not only guarantees the required power-supply, but also enhances system performance by up to 56.49 percent.
Barium Ion Selective Electrode Based on Natural Carboxylic Polyether Antibiotic Salinomycin (1987)

Abstract An ion-selective electrode based on a naturally ocurring carboxylic polyether antibiotic salinomycin is described which exhibits high Ba2+ selectivity. The selectivity coefficients of the electrode based on salinomycin, log Kpot BaCa, log Kpot BaK and log Kpot BaNa are −2.65, −2.86 and −3.55, respectively.
Fate of phase I and phase II Coxiella burnetii in several macrophage-like tumor cell lines (1981)

Several macrophage-like tumor cell lines of murine origin were exposed to phase I and phase II Coxiella burnetii, and the subsequent fate of the parasites was determined by electron and bright-field microscopy. Phase I C. burnetii proliferated within and established a persistent infection of P388D1, J774, and PU-5-IR cell lines but not of WEHI-3 and WEHI-274 cell lines. Phase II C. burnetii, however, entered into and persistently infected all five cell lines. The parasites proliferated within vacuoles. Macrophage cell lines persistently infected with phase I and phase II C. burnetii were maintained for over 200 and 100 days, respectively. Within P388D1 cells, the phase I C. burnetii converted, in part, to phase II; phase II organisms remained in the phase II state. The differential fate of the two rickettsial phases after exposure to the WEHI-3 and WEHI-274 cells may be attributable to surface differences such as lipopolysaccharide content.
2,6-Methano-2,6-dehydronorbornane: an exceptionally strained [3.1.1]propellane (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2,6-Methano-2,6-dehydronorbornane: an exceptionally strained [3.1.1]propellaneV. Vinkovic and Z. MajerskiCite this: J. Am. Chem. Soc. 1982, 104, 14, 4027–4029Publication Date (Print):July 1, 1982Publication History Published online1 May 2002Published inissue 1 July 1982https://pubs.acs.org/doi/10.1021/ja00378a052https://doi.org/10.1021/ja00378a052research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characteristics of Time-Distance Gait Parameters Across Speeds (2003)

This paper explores time-distance gait parameters across walking speeds. Our approach consists of designing an experiment to gather walking data at various speeds, analyzing time-distance features with respect to speeds. We explain the motivations of this study and the details of the experiment that allows people to walk naturally on the ground level floor and at the same time achieve a certain speed. The characteristics of gait features are demonstrated at the inter- and intra-individual levels.
Secretory Vesicles Membrane Area Is Regulated in Tandem with Quantal Size in Chromaffin Cells (2003)

The number of transmitter molecules released in a quantal event can be regulated, and recent studies suggest that the modulation of quantal size is associated with corresponding changes in vesicle volume (Colliver et al., 2000; Pothos et al., 2002). If so, this could occur either by distension of the vesicle membrane or by incorporation and removal of vesicle membrane. We performed simultaneous measurements of vesicle membrane area and catecholamine release in individual quantal events from chromaffin cells using cell-attached patch amperometry. Cells were treated with reserpine, a vesicular monoamine transport blocker that decreases quantal size, or l-dopa, a catecholamine precursor that increases quantal size. We show that decrease and increase in quantal size are associated with a respective decrease and increase in vesicle membrane area. These results point to a novel mechanism of vesicle membrane dynamics by which vesicles physically change their membrane area in response to changes in transmitter content such that the intravesicular concentration of transmitter is maintained.
Novel Chromatic-Dispersion-Induced Power Fading Compensation Technique for Broadband RoF Systems based on Dual-Frequency Driving of DP-MZM (2017)

We present and experimentally validate a simple and efficient technique to overcome the chromatic-dispersion-induced power-fading for broadband RoF systems. Using DP-MZM, the dispersion compensation is obtained by a complementary power-fading of the resulting electrical output from the two parallel MZMs.
Ectopic (Inappropriate) Hormone Production by Tumors: Mechanisms Involved and the Biological and Clinical Implications* (1980)

THE PRODUCTION of hormones and other “marker proteins” by tumors has come to play an increasingly important role for clinicians involved in the diagnosis and management of patients with neoplasia and for investigators involved in basic studies of tumor biology and endocrinology. It has become apparent during the past 30 to 40 years that a wide range of endocrine tumors secrete hormones not normally associated with the gland in which the neoplasm arises and that nonendocrine tumors can synthesize and/or secrete certain polypeptide hormones and other “tumor-associated” proteins. The production of such tumor markers has come to be referred to as “ectopic” or “inappropriate” when the marker in question is not obviously associated with the tissue from which the tumor derives. Since the recognition of this aspect of tumor behavior, considerable attention has been focused on the ectopic endocrine syndromes which may arise in patients with cancer because of such protein production, and on the important clinical implications of these syndromes for diagnosis and patient management.
Embedding non-Euclidean color spaces into Euclidean color spaces with minimal isometric disagreement (2007)

Isometric embedding of non-Euclidean color spaces into Euclidean color spaces is investigated. Owing to regions of nonzero Gaussian curvature within common non-Euclidean color spaces, we focus on the determination of transformations into Euclidean spaces with minimal isometric disagreement. A computational method is presented for deriving such a color space transformation by means of a multigrid optimization, resulting in a simple color look-up table. The multigrid optimization is applied on the CIELAB space with the CMC, CIE94, and CIEDE2000 formulas. The mean disagreement between distances calculated by these formulas and Euclidean distances within the new spaces is far below 3% for all investigated color difference formulas. Color space transformations containing the inverse transformations are provided as MATLAB scripts at the first author's website.
ChemInform Abstract: Novel Selective PDE4 Inhibitors. Part 1. Synthesis, Structure—Activity Relationships, and Molecular Modeling of 4‐(3,4‐Dimethoxyphenyl)‐2H‐phthalazin‐1‐ones and Analogues. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis (2019)

Inflammatory bowel disease increases the risk of developing colon cancer. Interleukin (IL-) 37 is a fundamental inhibitor of innate immunity by reducing systemic and local inflammation. IL-37 protein is expressed in healthy and diseased bowel and liver tissue. Here, we tested whether transgenic expression of human IL-37 protects IL-10 deficient (IL-10KO) mice from chronic colitis. IL-37tg mice were crossbred with IL-10KO mice. Homozygous IL-10KO/IL-37tg and IL10KO drank 2% dextran sulfate sodium (DSS) in water for 5 days to induce mild colitis. Colon carcinogenesis was triggered by intragastric administration of celecoxib. Endpoints were clinical parameters of colitis, cytokine responses in LPS-stimulated whole blood and explanted colon specimen and qPCR analysis of colon biopsies. Colon inflammation and number of adenoma-carcinoma were analyzed by histology. During the DSS-induction phase IL-10KO and IL-10KO/IL-37tg mice had a similar weight loss due to mild acute colitis. From day 115 there was a significantly improved weight gain in IL-10KO/IL37-tg mice, though colon length was similar. After <i>ex vivo</i> LPS stimulation whole blood of IL-10KO/IL-37tg compared to IL-10KO mice released less IL-6, IL-17, IFNγ, and TNFα and <i>ex vivo</i> colon cultures showed reduced IL-6 production both indicative of reduced inflammatory conditions under the influence of IL-37. Six out of 10 IL-10KO mice developed colon adenoma and carcinoma. Only one adenoma but no carcinoma was detected in colons of IL-10KO/IL-37tg mice. In conclusion, IL-37 transgene expression protects IL-10KO mice from colon carcinogenesis. It remains unclear whether IL-37 has direct tumor suppressing properties.
Patient Clinical Factors Influencing Use of Hysterectomy in New York, 2001–2005 (2008)

Alternatives to hysterectomy such as medical treatment, uterine artery embolization (UAE), and ablative therapy have become available and widely used in the last 10 years. It is unclear if these alternatives are replacing hysterectomy or delaying it. To determine the effect of patient clinical factors on the utilization of hysterectomy and alternatives of hysterectomy, the investigators examined all claims relating to a hysterectomy procedure or a hysterectomy-associated diagnosis in the database of a large insurance provider for 48 consecutive months from 2001 to 2005. A total of 295,148 claim lines were abstracted and analyzed by CPT and diagnostic grouping codes. Of the 7049 procedures represented in the claim lines, 1972 were hysterectomies and 5077 were hysterectomy alternatives. The mean age of patients filing claims was 39.1 years. Patients submitting claims for a hysterectomy were older than those having an alternative procedure (mean age, 49.7 v 46.0 years, P < .0001). The diagnostic group associated with the majority of all claims was abnormal bleeding (33%); the inflammation/mass/pain/endometriosis group accounted for 32%. The most common diagnostic groups associated with a hysterectomy were fibroids (39.4%), the inflammation/mass/pain/endometriosis category (14.7%), and cancer (13.0%). Bleeding represented the majority of claims for hysterectomy alternatives accounting for 60.5%; it accounted for only for 12.8% of the hysterectomies. The investigators conclude from these findings that patient factors of age and diagnostic group influence the utilization and timing of hysterectomy alternatives. These findings support the view that use of alternative procedures delay or reduce the need for hysterectomy.
Information and Low Back Pain Management (2006)

Information based on a biopsychosocial model is recommended in primary care to shift patient beliefs on low back pain. Nevertheless, information delivery alone is not sufficient to prevent absenteeism and reduce healthcare costs.
Change in quality of life in patients with relapsing–remitting multiple sclerosis over 2 years in relation to other clinical parameters: results from a trial of intramuscular interferon β-1a (2011)

Patients with disability progression defined using EDSS, the physician-derived primary outcome measure, had Physical SIP scores indicating worsening disability, validating the physician-derived primary outcome measure using patient self-report. Treatment with IFNβ-1a had beneficial effects on QoL in patients with worse SIP scores at baseline.