gebhart/patrepeval huggingface dataset:
Towards Analytics Aware Ontology Based Access to Static and Streaming\n Data (Extended Version) (2016)

Real-time analytics that requires integration and aggregation of\nheterogeneous and distributed streaming and static data is a typical task in\nmany industrial scenarios such as diagnostics of turbines in Siemens. OBDA\napproach has a great potential to facilitate such tasks; however, it has a\nnumber of limitations in dealing with analytics that restrict its use in\nimportant industrial applications. Based on our experience with Siemens, we\nargue that in order to overcome those limitations OBDA should be extended and\nbecome analytics, source, and cost aware. In this work we propose such an\nextension. In particular, we propose an ontology, mapping, and query language\nfor OBDA, where aggregate and other analytical functions are first class\ncitizens. Moreover, we develop query optimisation techniques that allow to\nefficiently process analytical tasks over static and streaming data. We\nimplement our approach in a system and evaluate our system with Siemens turbine\ndata.\n
Nanotube processing employing solid-condensed-gas-layers (2023)

In a method for processing a nanotube, a vapor is condensed to a solid condensate layer on a surface of the nanotube and then at least one selected region of the condensate layer is locally removed by directing a beam of energy at the selected region. The nanotube can be processed with at least a portion of the solid condensate layer maintained on the nanotube surface and thereafter the solid condensate layer removed. Nanotube processing can include, e.g., depositing a material layer on an exposed nanotube surface region where the condensate layer was removed. After forming a solid condensate layer, an electron beam can be directed at a selected region along a nanotube length corresponding to a location for cutting the nanotube, to locally remove the condensate layer at the region, and an ion beam can be directed at the selected region to cut the nanotube at the selected region.
Light-dependent governance of cell shape dimensions in cyanobacteria (2015)

The regulation of cellular dimension is important for the function and survival of cells. Cellular dimensions, such as size and shape, are regulated throughout the life cycle of bacteria and can be adapted in response to environmental changes to fine-tune cellular fitness. Cell size and shape are generally coordinated with cell growth and division. Cytoskeletal regulation of cell shape and cell wall biosynthesis and/or deposition occurs in a range of organisms. Photosynthetic organisms, such as cyanobacteria, particularly exhibit light-dependent regulation of morphogenes and generation of reactive oxygen species and other signals that can impact cellular dimensions. Environmental signals initiate adjustments of cellular dimensions, which may be vitally important for optimizing resource acquisition and utilization or for coupling the cellular dimensions with the regulation of subcellular organization to maintain optimal metabolism. Although the involvement of cytoskeletal components in the regulation of cell shape is widely accepted, the signaling factors that regulate cytoskeletal and other distinct components involved in cell shape control, particularly in response to changes in external light cues, remain to be fully elucidated. In this review, factors impacting the inter-coordination of growth and division, the relationship between the regulation of cellular dimensions and central carbon metabolism, and consideration of the effects of specific environment signals, primarily light, on cell dimensions in cyanobacteria will be discussed. Current knowledge about the molecular bases of the light-dependent regulation of cellular dimensions and cell shape in cyanobacteria will be highlighted.
A coupled vibratory gyroscope network with bi-directional, uni-directional, and direct coupling (2011)

In recent years, inertial sensors have been extensively studied and thoroughly researched to enhance their performance and robustness, overcoming great challenges for better innovations. The complicated fabrication processes of inertial sensors' manufacturing may potentially cause defects and lead to the reduction in their capabilities for detection of signals while environmental factors such as temperature can pose other obstacles and prevent the devices from obtaining the desired strength or stability. Among the many technologies that currently develop micromachined gyroscopes, MEMS (Microelectromechanical Systems) have been one of the fastest growing technologies used for gyroscope manufacturing due to their low-cost. However, one of the greatest challenges of the MEMS technology for micromachined gyroscopes is that it does not meet the requirements for inertial guidance systems. In this work, an approach is proposed to improve the robustness of a Coupled Inertial Navigation Sensor (CINS) System, which consists of a ring of vibratory gyroscopes coupled along their driving axes, bi-directionally, uni-directionary, and directly. While the sum response of synchronized states gains a larger output than an individual one, the purpose of the coupling in the drive-mode is to enhance the sensitivity and minimize the negative effects of the drift rate in a CINS device. Intensive numerical simulations are performed to investigate the behavior of this high dimensional system and its response to changes in parameters, mainly the number of gyroscopes, Coriolis force, and coupling strength. Bifurcation diagrams outlining the response of the system are obtained numerically with the aid of the continuation software AUTO 2000 and XPP. Individual behaviors, including synchronization, are further analyzed using analytical methods based on perturbation theory. The Lyapunov-Schmidt reduction is applied to determine the stability properties of the synchronized solution, which emerges through a pitchfork bifurcation that can be either supercritical or subcritical, depending on the coefficients of the nonlinear terms in the governing equations of motion. Abstract group theory is also used to predict the different patterns of motion for different ring sizes. The study of stochastic noise, assumed to be Gaussian band-limited, is explored extensively to investigate the benefits of the coupling systems over the uncoupled ones. Results show that coupling can reduce phase drift and even lead to a new concept of a drive-free gyroscope system.
Reversal of Left Ventricular Dysfunction Following Ablation of Atrial Fibrillation (2006)

Patients with AF and decreased LVEF undergoing AF ablation have similar success to patients with normal LVEF and have improvement in LVEF after ablation. These results suggest the presence of a reversible AF-induced ventricular cardiomyopathy in many patients with AF and depressed LV function. The presence of under-recognized and reversible cardiomyopathy even when tachycardia is not persistent is important to recognize.
Synthesis of deuterium‐, tritium‐, and carbon‐14‐labeled BILN2061, a potent hepatitis C virus protease inhibitor (2005)

Abstract Hepatitis C virus (HCV) serine protease is a target for antiviral therapy against HCV infection, a leading cause of liver transplantation in the US. BILN2061, (1 S , 4 R , 6 S , 7 Z , 14 S , 18 R )‐14‐cyclopentyloxycarbonylamino‐18‐[2‐(2‐isopropylamino‐thiazol‐4‐yl)‐7‐methoxyquinolin‐4‐yloxy]‐2,15‐dioxo‐3,16‐diazatricyclo[14.3.0.0 4,6 ]nonadec‐7‐ene‐4‐carboxylic acid, is a potent inhibitor of HCV and the first compound in this class of cyclic peptides in human trials. Here, we report the synthesis of deuterium‐labeled BILN2061 with isotopic enrichment of 99%, tritium‐labeled BILN2061 with a specific activity of 17.1 GBq/mmol, and carbon‐14‐labeled BILN2061 with a specific activity of 1.83 GBq/mmol. The isotopes were incorporated via a Hantzsch thiazole synthesis of labeled isopropyl thiourea and α ‐bromoketone intermediate. The preparation of labeled isopropyl thiourea is reported. Copyright © 2005 John Wiley &amp; Sons, Ltd.
ChemInform Abstract: Formation of Hollow Helicoids in Mesoporous Silica: Supramolecular Origami. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Measuring Saccade Latency Using Smartphone Cameras (2019)

By enabling repeat measurements of saccade latency and its distribution in individual subjects, our framework opens the possibility of quantifying patient state on a finer timescale in a broader population than previously possible.
Synthesizing High-performance Reconfigurable Meta-devices through Multi-objective Optimization (2021)

Metasurfaces offer the potential to realize large SWaP (size, weight, and power) reduction over conventional optical elements for their ability to achieve comparable functionalities in ultrathin geometries. Moreover, metasurfaces designed with phase change materials offer the potential to go beyond what is achievable by conventional optics by enabling multiple functionalities in a single reconfigurable meta-device. However, designing a single metasurface geometry that simultaneously achieves multiple desired functionalities while meeting all bandwidth requirements and fabrication constraints is a very challenging problem. Fortunately, this challenge can be overcome by the use of state-of-the-art multi-objective optimization algorithms which are well-suited for the inverse-design of multifunctional meta-devices.
Molecular Packing and Dynamics of the Main Chain and Side Chains in Mesomorphic Poly(vinyl ether)s As Revealed by X-ray Scattering, Dielectric Spectroscopy, Solid State 2H, and 13C-MAS NMR Spectroscopy (1998)

The conformational states and dynamics of a series of side-chain liquid crystalline poly(vinyl ether)s with phenylbenzoate or stilbenzyloxy as mesogen and with 4−11 methylene spacer groups, where the 11-methylene-spacer polymers had two different tacticities, were assessed by dielectric and NMR spectroscopy. Dielectric spectroscopy confirmed the presence of three subglass processes (β, γ, and δ) exhibiting an Arrhenius temperature dependence. The activation energy (35 ± 5 kJ/mol) of the γ process was insensitive to the morphology, and this process is assigned to localized motions within the spacer group. The absence of the β process in the stilbenzyloxy polymer suggests that this process is due to flips of the phenylene units causing a 180° reorientation of the carboxylic group in the phenyl benzoate moiety. The frequency of the flip of the inner phenylene unit at 0 °C as obtained by 13C-MAS NMR was almost the same as the frequency of the dielectric β loss peak at the same temperature. The relaxation strength of the β process passed through a maximum as the spacer length increased. It is suggested that the participating carboxyl groups were unable to reorient completely in a polymer with a short spacer group since reorientation of the mesogen was more complete in a polymer with longer spacer groups, the latter containing a smaller percentage of mesogens. 13C-MAS NMR data indicated that the gauche content of the spacer group was lower than that of a free polymethylene chain at the same temperature and that it increased with increasing temperature. The X-ray scattering patterns of the 11-methylene-spacer polymers with different tacticities were identical, and it was shown by NMR and dielectric spectroscopy that the molecular dynamics was not influenced by the tacticity of the polymers. The decrease in the thickness of the smectic layer at the transition from smectic B to smectic A is accompanied by a pronounced increase in segmental mobility of the backbone as revealed by 2H NMR spectroscopy.
ChemInform Abstract: Improved and Practical Procedures for the Preparation of Highly Substituted Pyridines and Pyridazines via Silica‐Mediated Aromatization. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Correction: CpG Promotes Cross-Presentation of Dead Cell-Associated Antigens by Pre-CD8α+ Dendritic Dells (2011)

de Brito, C., M. Tomkowiak, R. Ghittoni, C. Caux, Y. Leverrier, and J. Marvel. 2011. CpG promotes cross-presentation of dead cell-associated antigens by pre-CD8α+ dendritic dells. J. Immunol . 186: [1503–1511][1].

In the title, the phrase “Dendritic Dells” should be “Dendritic Cells”.
High efficiency micro solar cells integrated with lens array (2014)

We demonstrate high efficiency triple junction solar cells with submillimeter dimensions in an all-back-contact architecture. 550 × 550 μm2 cells flash at 41.3% efficiency under the air mass 1.5 direct normal spectrum at 50 W/cm2 at 25 °C. Compared to standard size production cells, the micro cells have reduced performance at 1-sun due to perimeter recombination, but the performance gap closes at higher concentrations. Micro cells integrated with lens arrays were tested on-sun with an efficiency of 34.7%. All-back-contact architecture and submillimeter dimensions are advantageous for module integration and heat dissipation, allowing for high-performance, compact, lightweight, and cost-effective concentrated photovoltaic modules.
Sustainable Design for the Direct Fabrication and Highly Versatile Functionalization of Nanocelluloses (2017)

This study describes a novel sustainable concept for the scalable direct fabrication and functionalization of nanocellulose from wood pulp with reduced energy consumption. A central concept is the use of metal-free small organic molecules as mediators and catalysts for the production and subsequent versatile surface engineering of the cellulosic nanomaterials via organocatalysis and click chemistry. Here, "organoclick" chemistry enables the selective functionalization of nanocelluloses with different organic molecules as well as the binding of palladium ions or nanoparticles. The nanocellulosic material is also shown to function as a sustainable support for heterogeneous catalysis in modern organic synthesis (e.g., Suzuki cross-coupling transformations in water). The reported strategy not only addresses obstacles and challenges for the future utilization of nanocellulose (e.g., low moisture resistance, the need for green chemistry, and energy-intensive production) but also enables new applications for nanocellulosic materials in different areas.
Distributed MIMO for Li-Fi: Channel Measurements, Ray Tracing and Throughput Analysis (2021)

LiFi has been considered as a promising candidate for future wireless indoor networks. The IEEE P802.15.13 and P802.11bb standardization groups agreed upon channel models generated using the non-sequential ray tracing approach of OpticStudio. In this paper, in order to validate the channel modelling approach, at first 2×2 multiple-input multiple-output (MIMO) channel measurements are carried out over 200 MHz bandwidth using a channel sounder. The experimental scenario is also modeled in 3D by applying ray tracing. The obtained results indicate good agreement between simulations and measured channel impulse responses, from which parameters such as path loss and delay spread are derived. After validating the channel modeling approach, we investigate the singular values and the effect of user mobility onto the performance in a 4×4 distributed multi-user MIMO scenario.
A phase 1 dose-escalation and -expansion study of IMP7068, a WEE1 inhibitor, in patients with advanced solid tumors. (2022)

e15052 Background: WEE1 kinase is a cell-cycle regulator that is important in DNA repair, and a validated antitumor target. IMP7068 is a potent and selective WEE1 inhibitor that has demonstrated antitumor activity in preclinical pharmacological models. A first-in-human, multicenter, open-label study was conducted to evaluate the safety, tolerability, pharmacokinetic (PK) characteristics, pharmacodynamic (PD) profiles and preliminary antitumor activity of IMP7068 in patients (pts) with advanced solid tumors. Methods: This phase 1 study included both a dose-escalation and dose-expansion stage. The dose-escalation stage was designed with 6 dose cohorts of IMP7068 at 30, 60, 120, 200, 300, and 400 mg (administered orally, once daily [QD] for 3 days, followed by 4 days off weekly for 21-day cycles). An accelerated titration design was used for the 30- and 60-mg dose levels, and an i3+3 design for all doses &gt; 60 mg. Pts were adults (age ≥18 years) with confirmed advanced solid tumors that were refractory or intolerant to standard treatment, or for which no standard treatment exists. The objectives of the dose-escalation stage were to evaluate the safety and tolerability, PK and PD profiles, and antitumor activity (per RECIST v1.1) of IMP7068. Results: As of Jan 7, 2022, 9 pts were enrolled in the dose-escalation phase (average age, 56 years). An additional cohort of IMP7068 160 mg was recommended by the Safety Monitoring Committee based on PK data from the 120-mg cohort. Pts received escalating doses at 30 mg (n = 1), 60 mg (n = 1), 120 mg (n = 3), and 160 mg (n = 4). No dose-limiting toxicities (DLTs) were observed. Treatment-related adverse events (TRAEs) occurred in 4 pts, most frequently alanine aminotransferase (ALT) increased, aspartate aminotransferase (AST) increased, and diarrhea (all in 2 pts each). Most TRAEs were grade 1 or 2 in severity; and only 1 patient had grade 3 TRAEs (AST and ALT increased). Time to reach the maximum plasma concentration of IMP7068 was approximately 2–6 hours following administration of 30–160 mg doses, respectively. Following repeated QD administration for 3 days, the accumulation ratios for IMP7068 exposure parameters C max and AUC 0-tau were 1.74–2.49 and 3.17–3.46, respectively, across the dose levels. The elimination half-life was approximately 10–28 hours after administration of 60–160 mg IMP7068. PD data showed that levels of phosphorylated cyclin-dependent kinase 1 decreased by ≥50% after treatment in the 160-mg cohort. Five of 8 evaluable pts had a best tumor response of stable disease (SD); 1 patient with colorectal cancer maintained a best response of SD for 22 weeks. Four pts remain on study. Conclusions: IMP7068 was well-tolerated with no DLTs, and conferred a meaningful PD effect and preliminary antitumor activity at doses of up to 160 mg in pts with advanced solid tumors. Dose escalation to establish the recommended phase 2 dose and/or maximum tolerated dose is continuing. Clinical trial information: NCT04768868.
Mechanism of Growth Inhibition of Prostate Cancer Xenografts by Valproic Acid (2012)

VPA inhibits tumor growth by multiple mechanisms including cell cycle arrest, induction of differentiation, and inhibition of growth of tumor vasculature.
Effects of Methyllycaconitine and Related Analogues on Bovine Adrenal α3β4* Nicotinic Acetylcholine Receptors (2002)

Adrenal secretion and binding studies were performed using ring E analogues of methyllycaconitine to assess structural determinants affecting activity on bovine adrenal alpha3beta4* nicotinic receptors. The most potent analogues are as potent as many inhibitors of adrenal secretion. Our data support the potential use of methyllycaconitine analogues to generate nicotinic receptor subtype-specific compounds.
Comparison of Foot Shapes during Gait between Low Group and Normal Group of Medial Longitudinal Arch (2013)

The disorder in which the medial longitudinal arch becomes lower is called flatfoot. It is inferred that the flatfoot condition is associated with a certain stress while walking. The purpose of this study was to compare the changes of medial longitudinal arch and floor reaction force during gait between two groups : low arch and normal arch, and to make a conjecture about the cause of flatfoot stress while walking. The subjects were 6 men and 6 women. The subjects, average age, average body height, and average weight were 23.5±2.5 years old, 165.6±8.2cm, and 56.5±10.8kg, respectively. We used medial longitudinal arch ratio, which is the value obtained by dividing the height from the floor surface to navicular bone by actual foot length. The lower arch group showed less than 16.4% of medial longitudinal arch ratio for men, 14.6% for women, among 6 subjects. The normal group showed larger values, among the 6 subjects. We measured configuration of arch and floor reaction force during gait movement at the times of heel strike, foot-flat, mid-stance, heel-off, and toe-off and compared them. We recorded the medial longitudinal arch, the changes of the medial arch angle between the line connecting medial heel area and the navicular bone, and the line connecting navicular bone and the first metatarsal head. Two units of high-speed cameras were used to measure this angle. Also measured, with two force plates, were the floor reaction force applied to the hind foot and the floor reaction force applied to the forefoot. At HC, FF, and HO phase, the arch angles were significantly larger in the low arch group than in the normal group. The low arch group had larger medial force than the normal group at MS and had smaller posterior force than the normal group at TO phase. As for the force components measured by force plates, from these results it appears that the low arch group, having lost the spring stiffness of the foot, is unable to make forward movement smoothly.
Computational Lexicography of Multi-Word Units: How Efficient Can It Be? (2010)

International audience
Supplementary Methods and Figures 1-8 from A Gonadotropin-Releasing Hormone-II Antagonist Induces Autophagy of Prostate Cancer Cells (2023)

Supplementary Methods and Figures 1-8 from A Gonadotropin-Releasing Hormone-II Antagonist Induces Autophagy of Prostate Cancer Cells
New statistical post processing approach for precise fault and defect localization in TRI database acquired on complex VLSI (2013)

International audience
Loss Reduction Mechanism for Coupled Cavity Waveguides in One-Dimensional Photonic Crystals (2008)

This paper presents a loss reduction mechanism for coupled cavity waveguides (CCWs) relying on 1-D photonic crystals microcavities. The mechanism is based on structural modification in the vicinity of the cavity defects. With appropriate modifications, the tangential wavenumber components of the leaky guided modes, which can couple to cladding modes, can be decreased, resulting in the reduction of propagation losses due to diffraction. We numerically demonstrate the usefulness of this mechanism through the design of low loss CCWs. The diffraction losses in the CCWs, where air holes adjacent to the defects are changed in size, decrease dramatically compared with CCWs with air holes of constant size. This loss reduction mechanism can be applied even to the CCWs with an increased number of intercavity air holes, while the group velocity can be further decreased.
Structure and Unique Interactions with DNA of a Cationic Trans‐Platinum Complex with the Nonplanar Bicyclic Piperidinopiperidine Ligand (2005)

Circumventing cisplatin resistance: The trans-[PtCl2(NH3)(pip-pip)]+ ion (see structure; red Pt, blue N, green Cl, gray C) is a cytotoxic compound with a cationic piperidinopiperidine ligand. The piperidine ring that is removed from the PtII center is fluxional and acts as a hydrogen-bond donor. The complex binds calf thymus DNA directly and rapidly (t1/2=11 min) without prior hydrolysis and circumvents cisplatin resistance in ovarian cancer cells. Supporting information for this article (NMR spectra of 1) is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z462389_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.