gebhart/patrepeval huggingface dataset:
Bordetella pertussis tracheal cytotoxin and other muramyl peptides: distinct structure-activity relationships for respiratory epithelial cytopathology. (1993)

Tracheal cytotoxin (TCT) is a disaccharide-tetrapeptide released by Bordetella pertussis, the causative agent of pertussis (whooping cough). We have previously determined the structure of TCT to be GlcNAc-1,6-anhydro-MurNAc-L-Ala-gamma-D-Glu-meso-A2pm-D-Ala, where MurNAc = N-acetylmuramic acid and A2pm = diaminopimelic acid. Purified TCT reproduces the respiratory cytopathology observed during pertussis, including ciliostasis and extrusion of ciliated cells. We have tested structural analogs of TCT for their ability to reproduce native TCT toxicity in explanted hamster tracheal tissue and hamster trachea epithelial (HTE) cell cultures. Other investigators have evaluated many of these analogs, which are muramyl or desmuramyl peptides, for muramyl peptide activities such as immunopotentiation, induction of slow-wave sleep, and pyrogenicity. Four desmuramyl peptides were produced in our laboratory from B. pertussis peptidoglycan or by chemical synthesis, including unusual peptides containing alpha-aminopimelic acid in place of A2pm. Based on the relative ability of compounds to inhibit DNA synthesis in HTE cells, truncated analogs lacking A2pm entirely or lacking only the side-chain amine or carboxyl group of A2pm were less active than TCT by a factor of at least 1000. All active analogs included a native or near-native peptide moiety, independent of the presence, absence, or substitution of the sugar moiety. We conclude that the structural requirements for TCT toxicity differ considerably from those for most other muramyl peptide activities, in that the disaccharide moiety is irrelevant for toxicity and both the free amino and carboxyl groups of the A2pm side chain are required for activity.
Simulation of transmission line transients using a personal computer (2003)

The authors present a technique for investigating traveling-wave phenomena on transmission lines using a personal computer. The transmission line is divided into n segments, each consisting of a series resistance and inductance and a shunt conductance and capacitance. A state model is formulated using the capacitor voltage and inductor currents as the state variables. Trapezoidal integration is used to convert the state equations to a set of linear difference equations which are very sparse. The state variables are updated by solving this set of equations. The technique has been verified using the Electromagnetic Transients Program. Execution times for several test cases indicate that it is suitable for use on personal computers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Onion-Shell Metal−Organic Polyhedra (MOPs): A General Approach to Decorate the Exteriors of MOPs using Principles of Supramolecular Chemistry (2008)

Metal-organic polyhedra with surface-exposed organic groups have been designed. The polyhedra are based on concentric shells of alternating negative-positive-negative charges and have been used to design homochiral hosts.
Experimental demonstration of remotely powered, controlled, and monitored optical switching based on laser-delivered signals (2021)

We experimentally demonstrate remotely powered, controlled, and monitored optical switching. The control signal of the switch is modulated on an optical wave and sent from a transmitter. At the switch location, the control signal is converted from an optical to an electrical signal to drive the switch. In addition, to provide electrical power at the switch location, optical power is sent from a distance and converted to electrical power using a series of photodiodes. We experimentally demonstrate (a) 1 Gb/s on-off keying data channel transmission and switching with a 1 MHz optically delivered control signal, and (b) 40 Gb/s quadrature phase-shift keying data channel transmission and remotely monitoring switch state and bias drift. The switching function is demonstrated without using any local electrical power supply. Moreover, the monitoring tones are transmitted to the remote switch and fed back to the transmitter to realize a switch state and detect the bias drift.
Continuous creation of a vortex in a Bose Einstein condensate with hyperfine spinF 2 (2002)

It is shown that a vortex can be continuously created in a Bose–Einstein condensate with hyperfine spin F = 2 in a Ioffe–Pritchard trap by reversing the axial magnetic field adiabatically. It may be speculated that the condensate cannot be confined in the trap since the weak-field seeking state makes transitions to the neutral and the strong-field seeking states due to the degeneracy of these states along the vortex axis when the axial field vanishes. We have solved the Gross–Pitaevskii equation numerically with given external magnetic fields to show that this is not the case. It is shown that a considerable fraction of the condensate remains in the trap even when the axial field is reversed rather slowly. This scenario is also analysed in the presence of an optical plug along the vortex axis. Then the condensate remains within the Fz = 2 manifold, with respect to the local magnetic field, throughout the formation of a vortex and hence the loss of atoms does not take place.
Resonant filtered fiber amplifiers (2013)

In this paper we present our recent result on utilizing resonant/bandgap fiber designs to achieve high performance ytterbium doped fiber amplifers for achieving diffraction limited beam quality in large mode area fibers, robust bending performance and gain shaping for long wavelength operation of yb-doped amplifiers.
[Clinical effect of rock salt aerosol therapy in treatment of occupational allergic contact dermatitis]. (2017)

<b>Objective:</b> To investigate the clinical effect and safety of rock salt aerosol therapy in the treatment of occupational allergic contact dermatitis. <b>Methods:</b> A total of 65 patients with acute exacerbation of occupational allergic contact dermatitis who were treated in the Outpatient Service and Inpatient Department of our hospital from March 2013 to December 2015 were enrolled and randomly divided into observation group and control group using a random number table. Both groups were givensymptomatic treatment including desensitization, and the patients in the observation group were given rock salt aerosol therapy for 2 courses in addition to the symptomatic treatment. The changes in symptoms, signs, blood eosinophil count, and IgE were observed. <b>Results:</b> There were significant changes in symptom score at the first and second courses of the treatment (<i>P</i><0.05) , and there was an interaction between time of therapy and grouping (<i>P</i><0.05) . There was no significant difference in symptom score before treatment between the two groups (<i>P</i>>0.05) , while there were differences at the first and second courses of the treatment (<i>P</i><0.05) . After the second course of treatment, the observation group had a significantly higher overall response rate than the control group (<i>P</i><0.05) ; both groups had significant reductions in blood eosinophil count and the observation group had a significantly greater reduction than the control group (<i>P</i><0.05) . After two courses of treatment, both groups had significant increases in the number of patients with normal IgE (both <i>P</i><0.05) , and after the second course of treatment, the observation group had a significantly higher number than the control group (<i>P</i><0.05) . Both groups had mild adverse events, which did not affect the treatment. <b>Conclusion:</b> In the treatment of occupational allergic contact dermatitis, rock salt aerosol therapy has a certain effect on the recovery of symptoms, signs, blood eosinophil count, and IgE.
Retinal microvascular changes and MRI signs of cerebral atrophy in healthy, middle-aged people (2003)

In healthy, middle-aged people, retinopathy is independently associated with sulcal and ventricular enlargement on MRI. This finding is compatible with the hypothesis that microvascular characteristics may influence the development of cerebral atrophic changes.
Cellular conditioning with trichostatin A enhances the anti‐stress response through up‐regulation of HDAC4 and down‐regulation of the IGF/Akt pathway (2008)

Evidence is accumulating that chromatin plays a major role in the control of cellular response to stress. This is best illustrated by the recent findings that chromatin-modifying factors of class III histone deacetylases (sirtuins) are capable of protecting cells from oxidative and genotoxic stress. In particular, Sirt1 has been shown to mimic the action of caloric restriction for the prevention of aging-associated diseases. In the present study, we have investigated the potential role of class I and II histone deacetylases (HDACs) in cellular protection against various stresses, including those caused by nutrient deprivation. For this, we utilized a cellular model in which expression of class I and II HDACs was altered as a result of cellular adaptation to trichostatin A (TSA), a selective inhibitor of these deacetylases. Our results indicated that TSA-resistant cells also developed resistance to H(2)O(2), DNA-damaging agents, and to nutrient deprivation. Interestingly, the insulin signaling pathway mediated by Akt was inhibited in the TSA-resistant cells, mirroring the effect of glucose deprivation on this pathway. Since expression of HDAC4 was consistently enhanced in the TSA-resistant cell lines, we suggest that this enzyme may contribute to their anti-stress response. In agreement with this, siRNA-mediated knockdown of HDAC4 in stress-resistant cells enhanced their sensitivity to the DNA-damaging drug doxorubicin and also to glucose deprivation. Akt phosphorylation was also up-regulated in response to HDC4 knockdown. Together, these findings suggest that cellular conditioning with TSA may represent a useful approach to mimic the effects of caloric restriction.
Towards MZI modulator in GeOI and SOI waveguide platforms for Mid-InfraRed wavelengths (2015)

Silicon-On-Insulator and Germanium-On-Insulator are both promising waveguide platforms for the mid-infrared wavelength of 2 μm. Here, we report the design of passive and active devices including multimode interference couplers (MMI) and MZI modulators built on both platforms.
MFP scanner motion characterization using self-printed target (2015)

Multifunctional printers (MFP) are products that combine the functions of a printer, scanner, and copier. Our goal is to help customers to be able to easily diagnose scanner or print quality issues with their products by developing an automated diagnostic system embedded in the product. We specifically focus on the characterization of scanner motions, which may be defective due to irregular movements of the scan-head. The novel design of our test page and two-stage diagnostic algorithm are described in this paper. The most challenging issue is to evaluate the scanner performance properly when both printer and scanner units contribute to the motion errors. In the first stage called the uncorrected-print-error-stage, aperiodic and periodic motion behaviors are characterized in both the spatial and frequency domains. Since it is not clear how much of the error is contributed by each unit, the scanned input is statistically analyzed in the second stage called the corrected-print-error-stage. Finally, the described diagnostic algorithms output the estimated scan error and print error separately as RMS values of the displacement of the scan and print lines, respectively, from their nominal positions in the scanner or printer motion direction. We validate our test page design and approaches by ground truth obtained from a high-precision, chrome-on-glass reticle manufactured using semiconductor chip fabrication technologies.
Small‐Molecule Sensing: A Direct Enzyme‐Linked Immunosorbent Assay for the Monosaccharide Kdo (2010)

Erst eingefangen, dann aufgespürt: Das Monosaccharid Kdo und ein immobilisiertes Einfangmolekül bilden ein kovalentes Addukt, das mit Addukt-spezifischen Antikörpern detektiert werden kann. Der Erkennungsvorgang ergibt ein Signal, das proportional zur Menge an Kdo in Lösung ist. Dieser Sensor sollte auf jegliche niedermolekulare Analyte anwendbar sein, die immunogene Addukte bilden können. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
372: Expression Analysis of the Vascular Endothelial Growth Factor (VEGF) Family in Renal Cell Carcinoma: Targeting the VEGF Pathway (2006)

You have accessJournal of UrologyDiscussed Poster, Sunday, May 21, 2006, 1:00 - 4:00 pm1 Apr 2006372: Expression Analysis of the Vascular Endothelial Growth Factor (VEGF) Family in Renal Cell Carcinoma: Targeting the VEGF Pathway John S. Lam, John T. Leppert, Hong Yu, David B. Seligson, Jun Dong, Steve Horvath, Allan J. Pantuck, Robert A. Figlin, and Arie S. Belldegrun John S. LamJohn S. Lam More articles by this author , John T. LeppertJohn T. Leppert More articles by this author , Hong YuHong Yu More articles by this author , David B. SeligsonDavid B. Seligson More articles by this author , Jun DongJun Dong More articles by this author , Steve HorvathSteve Horvath More articles by this author , Allan J. PantuckAllan J. Pantuck More articles by this author , Robert A. FiglinRobert A. Figlin More articles by this author , and Arie S. BelldegrunArie S. Belldegrun More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)32628-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "372: Expression Analysis of the Vascular Endothelial Growth Factor (VEGF) Family in Renal Cell Carcinoma: Targeting the VEGF Pathway." The Journal of Urology, 175(4S), p. 122 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 122 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information John S. Lam More articles by this author John T. Leppert More articles by this author Hong Yu More articles by this author David B. Seligson More articles by this author Jun Dong More articles by this author Steve Horvath More articles by this author Allan J. Pantuck More articles by this author Robert A. Figlin More articles by this author Arie S. Belldegrun More articles by this author Expand All Advertisement PDF downloadLoading ...
Escherichia coli nusG mutations that block transcription termination by coliphage HK022 Nun protein (1999)

The Escherichia coli nusG gene product is required for transcription termination by phage HK022 Nun protein at the lambda nutR site in vivo. We show that it is also essential for Nun termination at lambda nutL. Three recessive mis-sense nusG mutations have been isolated that inhibit termination by Nun at lambda nutR. The mutations are ineffective in a lambda pL nutL fusion, even when lambda nutR replaces lambda nutL. The mutant strains support lambda growth, indicating that lambda N antitermination activity is not impaired. Transcription arrest by Nun in vitro is stimulated by NusG protein at both lambda nutR and lambda nutL. Mutant NusG protein fails to enhance transcriptional arrest by Nun at either site. The mutant protein, like the wild-type protein, suppresses transcriptional pausing by RNA polymerase and stimulates Rho-dependent termination. These results imply that the role of NusG in Nun termination may be distinct from its roles in other transcription reactions.
ChemInform Abstract: Reduction and Isomerization of Oxiranes and α‐Diazo Ketones by Various Early Transition Metallocenes. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Photoinduced Electron Transfer of ZnS–AgInS2 Solid-Solution Semiconductor Nanoparticles: Emission Quenching and Photocatalytic Reactions Controlled by Electrostatic Forces (2013)

The electron transfer between the fluorescent ZnS–AgInS2 solid-solution (ZAIS) nanoparticles (NPs) and redox species is investigated in an aqueous solution in terms of chemosensors and photocatalysts. In a case where the ZAIS NPs and quenchers are oppositely charged, very efficient photoluminescence (PL) quenching (KS ≈ 106 M–1) is observed because of the specific adsorption of quenchers on particles. The quenching magnitude increases with the potential gap between the photoexcited NPs and quenchers. Methyl viologen (MV2+) shows the largest quenching behavior; i.e., it is revealed to quench most of PL by the adsorption of only a single molecule. In such a case, the linearity of quenching magnitude is lost, and distribution of the quencher adsorption on NPs should be considered to clarify the quenching mechanism. In the opposite case where both the ZAIS NPs and quenchers are negatively charged, although the quenching efficiency is two to three orders of magnitude lower than that in the aforementioned adsorption case, electron transfer occurs from the NPs to redox species. The efficiency of photoreduction is investigated in association with the charge repulsion between both species.
Distribution of a New Invasive Species, Sipha maydis (Heteroptera: Aphididae), on Cereals and Wild Grasses in the Southern Plains and Rocky Mountain States (2019)

Sipha maydis Passerini (Heteroptera: Aphididae) is a cereal pest with an extensive geographical range that includes countries in Europe, Asia, Africa, and South America. Reports of S. maydis in the United States have been infrequent since it was first detected in California, 2007. Two studies, focused (NW CO) and multistate (OK, TX, NM, CO, UT, WY), were conducted to determine the distribution and host range of S. maydis in the Rocky Mountain and Southern Plains states over a 3-yr period, 2015-2017. In 2015, focused sampling in NW Colorado found S. maydis at 59% of the 37 sites, primarily on wheat. Sipha maydis did not survive extreme winter temperatures from late December 2015 to early January 2016 that ranged from -9.0 to -20.9°C over a 9-d period, which resulted in no aphids detected in 2016. In the multistate study, S. maydis occurred in 14.6% of 96 sites sampled in 2015, 8% of 123 sites in 2016, and 9% of 85 sites in 2017 at wide range of altitudes from 1,359 to 2,645 m. Sipha maydis occurred mainly in NW and SW Colorado and NE New Mexico along with a few sites in NE Colorado, SE Utah, and SE Wyoming. This aphid mainly infested wheat followed by a variety of eight wild grass species. No parasites, predators, sexual morphs, or significant plant damage occurred at the sites. Sipha maydis utilized 14 hosts in the United States including 8 new host records, which expands its host range to 52 plant species worldwide. Sipha maydis may be of concern to wheat, barley, and sorghum production in the United States if its populations continue to increase.
The Antiproliferative and Apoptotic Effect of a Novel Synthesized S-Triazine Dipeptide Series, and Toxicity Screening in Zebrafish Embryos (2021)

Several derivatives containing morpholine/piperidine, anilines, and dipeptides as pending moieties were prepared using <i>s</i>-triazine as a scaffold. These compounds were evaluated for their anticancer activity against two human breast cancer cell lines (MCF-7 and MDA-MB-231), a colon cancer cell line (HCT-116), and a non-tumorigenic cell line (HEK 293). Tamoxifen was used as a reference. Animal toxicity tests were carried out in zebrafish embryos. Most of these compounds showed a higher activity against breast cancer than colon cancer. Compound <b>3a</b>-which contains morpholine, aniline, and glycylglycinate methyl ester-showed a high level of cytotoxicity against MCF-7 cells with IC<sub>50</sub> values of less than 1 µM. This compound showed a much lower level of toxicity against the non-tumorigenic HEK-293 cell line, and in the in vivo studies using zebrafish embryos. Furthermore, it induced cell cycle arrest at the G2/M phase, and apoptosis in MCF-7 cells. On the basis of our results, <b>3a</b> emerges as a potential candidate for further development as a therapeutic drug to treat hormone receptor-positive breast cancer.
Challenges of Single-Wafer Wet Cleaning for Low Temperature Pre-Epitaxial Treatment of SiGe (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
MOSIEVIUS: FEATURE DRIVEN INTERACTIVE AUDIO MOSAICING (2003)

The process of creating an audio mosaic consists of the concatenation of segments of sound. Segments are chosen to correspond best with a description of a target sound specified by the desired features of the final mosaic. Current audio mosaicing techniques take advantage of the description of future target units in order to make more intelligent decisions when choosing individual segments. In this paper, we investigate ways to expand mosaicing techniques in order to use the mosaicing process as an interactive means of musical expression in real time.
Perspectives on complement and phagocytic cell responses to nanoparticles: From fundamentals to adverse reactions (2023)

The complement system, professional phagocytes and other cells such as Natural killer cells and mast cells are among the important components of the innate arm of the immune system. These constituents provide an orchestrated array of defences and responses against tissue injury and foreign particles, including nanopharmaceuticals. While interception of nanopharmaceuticals by the immune system is beneficial for immunomodulation and treatment of phagocytic cell disorders, it is imperative to understand the multifaceted mechanisms by which nanopharmaceuticals interacts with the immune system and evaluate the subsequent balance of beneficial versus adverse reactions. An example of the latter is adverse infusion reactions to regulatory-approved nanopharmaceuticals seen in human subjects. Here, we discuss collective opinions and findings from our laboratories in mapping nanoparticle-mediated complement and leucocyte/macrophage responses.
Simulation methods for generating reduced order models of MEMS sensors with geometric nonlinear drive motion (2018)

We compare different simulation methods for the development of reduced order models (ROM) that feature a geometric nonlinear drive motion in a MEMS device. We benchmark three different simulation methods by comparing the results to measured frequency shifts of a MEMS gyroscope. We find that quasi-static points in the dynamic trajectory of the gyroscope are suitable deflection states for generating the modal stiffness. Furthermore, we show an efficient simulation method that overcomes the burden of the transient FE simulation while exhibiting similar accuracy.