gebhart/patrepeval huggingface dataset:
Synthetic Utilization of α-Phosphonovinyl Anions (1999)

The α-phosphonovinyl anions, generated in situ from treatment of β-hetero-substituted vinyl-phosphonates 1a-c with LDA (or LTMP), were trapped with various electrophiles such as chlorotriorganosilanes, chlorotrimethylgermane, chlorotriorganotins, dimethyl disulfide, and halogen to afford the corresponding β-hetero-substituted α-functionalized vinylphosphonates 2–14 in good to excellent yields. The Friedel-Crafts reaction of α-(silyl) or α-(germyl)phosphonoketene dithioacetals 2, 9 or 4 with acid chlorides gave α-acylated phosphonoketene dithioacetals 15–19 in 53–91 % yields. The palladium-catalyzed cross-coupling reaction of β-ethoxy-α-(tributylstannyl)vinylphosphonate 13 with a variety of organic halides (R = acyl, allyl, aryl etc.) provided β-ethoxy-α-substituted vinylphosphonates 20–25 in good to moderate yields. The palladium-mediated cross-coupling reaction of α-(iodo)-vinyl-phosphonates 7, 14 with terminal acetylenes afforded α-alkynylated vinylphosphonates 26–29 in 69–83 % yields.
Multi-view reconstruction using photo-consistency and exact silhouette constraints: a maximum-flow formulation (2005)

This paper describes a novel approach for reconstructing a closed continuous surface of an object from multiple calibrated color images and silhouettes. Any accurate reconstruction must satisfy (1) photo-consistency and (2) silhouette consistency constraints. Most existing techniques treat these cues identically in optimization frameworks where silhouette constraints are traded off against photo-consistency and smoothness priors. Our approach strictly enforces silhouette constraints, while optimizing photo-consistency and smoothness in a global graph-cut framework. We transform the reconstruction problem into computing max-flow/min-cut in a geometric graph, where any cut corresponds to a surface satisfying exact silhouette constraints (its silhouettes should exactly coincide with those of the visual hull); a minimum cut is the most photo-consistent surface amongst them. Our graph-cut formulation is based on the rim mesh, (the combinatorial arrangement of rims or contour generators from many views) which can be computed directly from the silhouettes. Unlike other methods, our approach enforces silhouette constraints without introducing a bias near the visual hull boundary and also recovers the rim curves. Results are presented for synthetic and real datasets.
Glycemic Control and Clinical Outcomes in U.S. Patients With COVID-19: Data From the National COVID Cohort Collaborative (N3C) Database (2022)

In a large, multicenter cohort of patients in the U.S. with T2D and COVID-19 infection, risk of hospitalization increased with incrementally higher HbA1c levels. Risk of death and invasive ventilation also increased but plateaued at different levels of glycemic control.
649. Cefiderocol in Treating Patients Confirmed with Gram-negative Infections in US Hospital During Jan 2020 - Jun 2021 (2022)

Abstract Background Cefiderocol (CFDC) has a broad activity against Gram-negative (GN) pathogens. This study describes the usage of CFDC in US hospitals in patients with microbiology data during the initial phase of commercialization. Methods This retrospective study included patients with laboratory-confirmed GN infections in US hospitals treated with CFDC consecutively for ≥3 days between March 2020 to June 2021, as captured by Premier Healthcare data. This study describes the clinical characteristics, microbiology profile, CFDC usage, and post-CFDC initiation 14-day and 28-day in-hospital all-cause mortality (IH-ACM). Index culture was defined as the last day that culture sample(s) was taken before CFDC initiation or the first day the culture sample(s) was taken after CFDC initiation if no microbiology data before CFDC use was available. Index pathogens were all pathogens identified from the index culture(s). The index culture site was where the index culture was taken. Results A total 187 in-patients received ≥3 days CFDC and had ≥1 microbiological result(s). The clinical characteristics of the patients and index culture results are provided in Table 1 and Table 2. About 60% of patients had at least one positive respiratory culture. The most frequent pathogens from the index culture were Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Klebsiella pneumoniae, and Acinetobacter baumannii. Nearly 75% of patients had one index pathogen, and 91% with one culture site. Almost 30% of patients had either one pathogen identified in multiple culture sites, or multiple pathogens from ≥1 culture site. Crude 28-day IH-ACM for patients with any A. baumannii was 8.3% (95%CI: 0% -19.4%), any P. aeruginosa was 17.3% (95%CI: 9.9-24.8%), any S. maltophilia was 18.4%, (95%CI: 6.1%-44.0%) and any K. pneumoniae was 26.1% (95%CI: 8.1%-44.0%). Crude 28-day IH-ACM for patients with positive respiratory culture was five times higher in COVID patients than non-COVID patients. Conclusion During the initial phase of CFDC availability, the most frequent pathogens treated using CFDC were non-fermenters, and the most frequent culture site was respiratory. IH-ACM appears to be affected by infection characteristics, especially COVID-19 status. Disclosures Bin Cai, MD, PhD, Shionogi: Shionogi employee Yun Zhou, MS, Shionogi: Employee of CRO hired by Shionogi Andrew Cooper, PhD, Shionogi: Shionogi employee.
Keeping the noise down (2016)

Transgenic mice have revealed how the cochlea protects itself from loud noise and why some people may be more susceptible to hearing loss than others.
Modulation of Na-K-ATPase activity in the mouse medullary thick ascending limb of Henle. Effects of mineralocorticoids and sodium. (1988)

This study investigates the effect of variations in mineralocorticoid as well as cell sodium delivery and uptake on Na-K-ATPase activity in the mouse medullary thick ascending limb of Henle (mTALH). Pharmacologic doses of the mineralocorticoid deoxycorticosterone acetate (DOCA) resulted in a 28% increase of Na-K-ATPase activity. Furosemide-induced inhibition of sodium uptake by the mTALH cell also resulted in Na-K-ATPase activity reduction (45%). Sodium deprivation did not cause a clear change in enzyme activity, either at 3 d or 2 wk, likely reflecting the result of the opposing influences of decreased sodium delivery and increased endogenous aldosterone. Finally, the behavior of Na-K-ATPase activity at 3 d of sodium deprivation in the mTALH contrasted with a 60% increase in activity observed in the cortical collecting tubule, a nephron segment known to be responsive to mineralocorticoid, and this heterogeneity of response may suggest an important role for the mTALH in maintaining salt homeostasis.
Multi-Objective Optimization for 3D Placement and Resource Allocation in OFDMA-based Multi-UAV Networks (2023)

This work considers the orthogonal frequency division multiple access (OFDMA) technology that enables multiple unmanned aerial vehicles (multi-UAV) communication systems to provide on-demand services. The main aim of this work is to derive the optimal allocation of radio resources, 3D placement of UAVs, and user association matrices. To achieve the desired objectives, we decoupled the original joint optimization problem into two sub-problems: i) 3D placement and user association and ii) sum-rate maximization for optimal radio resource allocation, which are solved iteratively. The proposed iterative algorithm is shown via numerical results to achieve fast convergence speed after less than 10 iterations. The benefits of the proposed design are demonstrated via superior sum-rate performance compared to existing reference designs. Moreover, the results declared that the optimal power and sub-carrier allocation helped mitigate the co-cell interference that directly impacts the system’s performance.
Identification of Saccharomyces cerevisiae GLY1 as a threonine aldolase: a key enzyme in glycine biosynthesis (2006)

Determination of enzyme-specific activities revealed that GLY1 encodes a threonine aldolase (TA) in Saccharomyces cerevisiae. A knock-out mutant auxotrophic for glycine lacked detectable activity. After transformation with YEp24GLY1 glycine prototrophy was restored and TA-specific activity was 16-fold higher than in the wild type. Growth experiments using glucose as the sole carbon source showed that GLY1 is more important for glycine biosynthesis than SHM1 and SHM2 encoding alternative serine hydroxymethyltransferases. On ethanol as carbon source simultaneous disruption of GLY1, SHM1 and SHM2 did not lead to glycine auxotrophy because glycine biosynthesis proceeds via alanine glyoxylate aminotransferase.
A 3.3-Gb/s SPAD-Based Quantum Random Number Generator (2023)

Quantum random number generators (QRNGs) are a burgeoning technology used for a variety of applications, including modern security and encryption systems. Typical methods exploit an entropy source combined with an extraction or bit generation circuit in order to produce a random string. In integrated designs, there is often little modeling or analytical description of the entropy source, circuit extraction, and post-processing provided. In this work, we present a single-photon avalanche diode (SPAD)-based QRNG design, which utilizes the quantum random flip-flop (QRFF) method. Extensive modeling of detector and circuit imperfections that result in entropy degradation is performed. A new method to analytically model serial autocorrelations of the proposed bit generation method, which includes detector dead time, is proposed. Then, a Verilog-AMS model is developed in order to validate the analytical model in simulation. A novel transistor implementation of the QRFF circuit is presented, which enables compensation of the degradation in entropy inherent to the finite non-symmetric transitions of the random flip-flop. Finally, a full system containing two independent arrays of the QRFF circuit is manufactured and tested in a 55-nm bipolar–CMOS–DMOS (BCD) technology node, demonstrating bit generation statistics that are commensurate to the developed model. The full chip is able to generate 3.3 Gb/s of data when operated with an external LED. Pixelwise and spatial analysis of bias and correlation is performed. NIST STS (SP 800-22) and SP 800-90B are used to benchmark the generated bit strings.
Controlling Surface Morphology of Electrospun Polystyrene Fibers:  Effect of Humidity and Molecular Weight in the Electrospinning Process (2003)

Electrospinning is a technique used to produce micron to submicron diameter polymeric fibers. The surface of electrospun fibers is important when considering end-use applications. For example, the ability to introduce porous surface features of a known size is required if nanoparticles need to be deposited on the surface of the fiber or if drug molecules are to be incorporated for controlled release. Surface features, or pores, became evident when electrospinning in an atmosphere with more than 30% relative humidity. Increasing humidity causes an increase in the number, diameter, shape, and distribution of the pores. Increasing the molecular weight of the polystyrene (PS) results in larger, less uniform shaped pores. This work includes an investigation of how humidity and molecular weight affect the surface of electrospun PS fibers. The results of varying the humidity and molecular weight on the surface of electrospun PS fibers were studied using optical microscopy, field emission scanning electron microscopy (FESEM), and atomic force microscopy (AFM) coupled with image analysis.
Analysis of premature breakdown in high-power devices using IBIC microscopy (2005)

Ion beam induced charge (IBIC) microscopy is used mainly for analysis of various semiconductor parameters such as diffusion length and lifetime of the charge carriers. In this paper, we show that IBIC microscopy is also useful for the visualization of the electrical field distribution within depletion regions of electronic devices. The ions penetrating into the semiconductor generate electron-hole pairs that are separated and accelerated depending on the internal electric field distribution. The shape of the resulting current induced in this way is dependent on the electric field. This dependence and the large penetration depth of the light ions allow the analysis of electric field distributions within semiconductor devices up to a few tens of microns below the device surface. Therefore, IBIC microscopy is a very useful analytical tool for the characterization of the electrical field distribution within high-power devices, even when the semiconductor is covered with thick passivation or metallization layers.
Directional Cell Discovery in Millimeter Wave Cellular Networks (2014)

The acute disparity between increasing bandwidth demand and available spectrum, has brought millimeter wave (mmW) bands to the forefront of candidate solutions for the next-generation cellular networks. Highly directional transmissions are essential for cellular communication in these frequencies to compensate for high isotropic path loss. This reliance on directional beamforming, however, complicates initial cell search since the mobile and base station must jointly search over a potentially large angular directional space to locate a suitable path to initiate communication. To address this problem, this paper proposes a directional cell discovery procedure where base stations periodically transmit synchronization signals, potentially in time-varying random directions, to scan the angular space. Detectors for these signals are derived based on a Generalized Likelihood Ratio Test (GLRT) under various signal and receiver assumptions. The detectors are then simulated under realistic design parameters and channels based on actual experimental measurements at 28~GHz in New York City. The study reveals two key findings: (i) digital beamforming can significantly outperform analog beamforming even when the digital beamforming uses very low quantization to compensate for the additional power requirements; and (ii) omni-directional transmissions of the synchronization signals from the base station generally outperforms random directional scanning.
HER4 in breast cancer: comparison of antibodies against intra- and extra-cellular domains of HER4 (2006)

The difference in antigen site may explain the different staining patterns we have seen with respect to location; with each antibody appearing to select for distinct compartments. Thus, HFR1 may select for cytoplasmic and nuclear HER4 ICD, whilst H4.77.16 selects for membranous HER4 and/or HER4 being recycled in cytoplasm or nucleus. This ability to distinguish between site and function of HER4 and its fragments is particularly important, with recent evidence highlighting the different functions of nuclear and mitochondrial HER4.
ChemInform Abstract: Ring‐Closing Metathesis in Methanol and Water. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Starfruit-Shaped Gold Nanorods and Nanowires: Synthesis and SERS Characterization (2012)

Recently, branched and star-shaped gold nanoparticles have received significant attention for their unique optical and electronic properties, but most examples of such nanoparticles have a zero-dimensional shape with varying numbers of branches coming from a quasi-spherical core. This report details the first examples of higher-order penta-branched gold particles including rod-, wire-, and platelike particles which contain a uniquely periodic starfruitlike morphology. These nanoparticles are synthesized in the presence of silver ions by a seed-mediated approach based on utilizing highly purified pentahedrally twinned gold nanorods and nanowires as seed particles. The extent of the growth can be varied, leading to shifts in the plasmon resonances of the particles. In addition, the application of the starfruit rods for surface-enhanced Raman spectroscopy (SERS) is demonstrated.
Gliotoxicity, reverse transcriptase activity and retroviral RNA in monocyte/macrophage culture supernatants from patients with multiple sclerosis (1997)

In investigating a possible link between a novel retroviral agent (provisionally called MSRV), recently characterised in multiple sclerosis (MS), and the neuropathology of MS, it was found that there was a significant correlation between gliotoxicity and reverse transcriptase activity in monocyte/macrophage culture supernatants (MMCS) unique to MS patients. MMCS from healthy controls and patients with other neurological diseases did not display either gliotoxicity or reverse transcriptase activity. The observed gliotoxic effect was an initial, intermediate filament network disorganization and subsequent cell death which was specific to astrocytes and oligodendrocytes. The reverse transcriptase activity and MSRV-specific RNA were observed during the first 2 weeks of culture in MMCS from patients with active MS. The further elucidation of the molecular form(s) of this gliotoxic factor and its original source may be crucial in elucidating important etiopathogenic mechanisms in MS.
FinFET-induced anisotropy in printing of implantation shapes (2017)

In advanced technological nodes, the photoresist absorbs light, which is reflected by underlying topography during optical lithography of implantation layers. Anti-reflective coating (ARC) helps to suppress the reflections, but ARC removal may damage transistors, not to mention its relatively high cost. Therefore ARC is usually not used, and topography modeling becomes obligatory for printing implantation shapes. Furthermore, presence of Fin Field Effect Transistors (FinFETs) makes modeling of non-uniform substrate reflections exceptionally challenging. In realistic designs, the same implantation shape may be found in a vertical or in a rotated horizontal orientation. This creates two types of relationships between the critical dimension (CD) and FinFET, namely parallel to and perpendicular to the fins. The measurement data shows that CDs differ between these two orientations. This discrepancy is also revealed by our Rigorous Optical Topography simulator. Numerical experiments demonstrate that the shape orientation may introduce CD differences of up to 45 nm with a 248 nm illumination for 14 nm technology. These differences are highly dependent on the enclosure (distance between implantation shape and active area). One of the major causes of the differences is that in the parallel orientation the shape is facing solid sidewalls of fins, while the perpendicular oriented shape “sees” only perforated sidewalls of the fin structure, which reflect much less energy. Meticulously stated numerical experiments helped us to thoroughly understand anisotropic behavior of CD measurement. This allowed us to more accurately account for FinFET-related topography effects in the compact implantation modeling for optical proximity corrections (OPC). This improvement is validated against wafer measurement data.
A 45nm CMOS 0.35v-optimized standard cell library for ultra-low power applications (2009)

Ultra-low voltage is now a well known solution for energy constrained applications designed using nanometric process technologies. This work is focused on setting-up an automated methodology to enable the design of ultra-low voltage digital circuits exclusively using standard EDA tools. To achieve this goal, a 0.35V energy-delay optimized library was developed. This library, fully compliant with standard library design flow and characterization, was verified through the design and fabrication of a BCH decoder circuit, following a standard front-end to back-end flow. It performs at 457 kHz, with a total energy consumption of 2.9fJ per cycle.
Dual-Frequency Broadband-Stacked Microstrip Antenna Using a Reactive Loading and a Fractal-Shaped Radiating Edge (2007)

A dual-band enhanced-bandwidth microstrip antenna is presented with a frequency separation of f2/f1=1.37. In order to achieve the dual-frequency operation, a rectangular patch antenna is reactively loaded with a stub placed along one of the radiating edges. Then, the bandwidth is enhanced using a stacked parasitic technique, whereas the matching and radiation characteristics are kept constant along each band and similar at two bands.
Quantitation of HIV-1 Entry Cofactor Expression (2003)

Infection of CD4+ T-lymphocytes by HIV-1 is initiated by binding of the virus to the CD4 receptor on the lymphocyte surface, followed by fusion of the virus with the cell membrane (1). However, expression of CD4 on certain non-human cells does not render them permissive for HIV-1 entry, suggesting that an additional entry cofactor is required (2,3). The identity of this cofactor remained elusive until Berger and colleagues reported that the α-chemokine receptor fusin/CXCR4 functions as the entry cofactor for T-cell line-tropic isolates of HIV-1 (4). Subsequent progress in the field has been rapid. To date, three β-chemokine receptors (CCR2b, CCR3, and CCR5) have also been identified as HIV-1 entry cofactors (5).
Aortic 4D flow MRI in 2 minutes using compressed sensing, respiratory controlled adaptive k‐space reordering, and inline reconstruction (2019)

Aortic 4D flow with CS is feasible in a two minute scan with less than 5 min for inline reconstruction. While net flow agreement was excellent, CS with R = 7.7 produced underestimation of Q<sub>max</sub> and v<sub>max</sub> ; however, these were generally within 13% of conventional 4D flow-derived values. This approach allows 4D flow to be feasible in clinical practice for comprehensive assessment of hemodynamics.
Mechanism of Electric Power Generation from Ionic Droplet Motion on Polymer Supported Graphene (2018)

Graphene-based electric power generation that converts mechanical energy of flow of ionic droplets over the device surface into electricity has emerged as promising candidate for a blue-energy network. Yet the lack of a microscopic understanding of the underlying mechanism has prevented ability to optimize and control the performance of such devices. This requires information on interfacial structure and charging behavior at the molecular level. Here, we use sum-frequency vibrational spectroscopy (SFVS) to probe the interfaces of devices composed of aqueous solution, graphene and supporting polymer substrate. We discover that the surface dipole layer of the polymer is responsible for ion attraction toward and adsorption at the graphene surface that leads to electricity generation in graphene. Graphene itself does not attract ions and only acts as a conducting sheet for the induced carrier transport. Replacing the polymer by an organic ferroelectric substrate could enhance the efficiency and allow switching of the electricity generation. Our microscopic understanding of the electricity generation process paves the way for the rational design of scalable and more efficient droplet-motion-based energy transducer devices.