gebhart/patrepeval huggingface dataset:
EFFICACY AND SAFETY OF INNOVATIVE SUNSCREEN (E) -4- (TERT-BUTYL) -N '- ((E) -3- (4-METHOXYPHENYL) ALLYLIDENE) BENZIDRAZIDA (TBMAB) (2021)

The constant or repeated unprotected exposure to solar radiation can result in the onset of various harmful effects, such as inflammation, genetic mutation and hyperpigmentation, even than previous photoaging. The use of photoprotective formulations is one of the most effective tools to avoid this. However, most of the UV filters are unstable to UV radiation, can even permeate the skin and cause hepatotoxic effects. The aim of this study was to assess the efficacy and safety of a innovative sunscreen substance (E) -4- (tert-butyl) -N '- ((E) -3- (4-methoxyphenyl) allylidene) benzhydrazide. Methodology: The sunscreen formulation containing the innovative substance was subjected to various stress conditions: 45±2° C, 5±2° C and exposure to sunlight. These samples were evaluated in relation to its rheology, pH, viscosity, density and SPF to determine its stability. The assessment of TBMAB release from the formulation was performed in Microette equipment. Hepatoma cells (HepG2) were used to determine the TBMAB cytotoxicity. Results and Discussion: In the stability study, no significant changes were observed in the formulation. The maximum concentration of TBMAB released from the formulation was 3.63 µg.cm-2. Also, it was evident the cytotoxic effect on the concentrations well above 3.63 µg.cm-2,displaying the safety of this substance, considering HepG2 cells. Conclusion: These results demonstrate that TBMAB is a suitable innovative substance to be used in suscreens, exhibiting stability, desired SPF value and safety, considering HepG2 cells. Thus, it could be a new alternative to prevent skin cancer.
4.1: Invited Paper : Electronic Structure, Carrier Transport, Defects and Impurities in Amorphous Oxide Semiconductor (2013)

Abstract This review paper provides the present status of amorphous oxide semiconductor technology along with knowledge obtained to date on their carrier transport, defects and impurities in relation to their stability issues.
On the Fingerprinting of Software-Defined Networks (2016)

Software-defined networking (SDN) eases network management by centralizing the control plane and separating it from the data plane. The separation of planes in SDN, however, introduces new vulnerabilities in SDN networks, since the difference in processing packets at each plane allows an adversary to fingerprint the network's packet-forwarding logic. In this paper, we study the feasibility of fingerprinting the controller-switch interactions by a remote adversary, whose aim is to acquire knowledge about specific flow rules that are installed at the switches. This knowledge empowers the adversary with a better understanding of the network's packet-forwarding logic and exposes the network to a number of threats. In this paper, we collect measurements from hosts located across the globe using a realistic SDN network comprising of OpenFlow hardware and software switches. We show that, by leveraging information from the RTT and packet-pair dispersion of the exchanged packets, fingerprinting attacks on SDN networks succeed with overwhelming probability. We additionally show that these attacks are not restricted to active adversaries, but can also be mounted by passive adversaries that only monitor traffic exchanged with the SDN network. Finally, we discuss the implications of these attacks on the security of SDN networks, and we present and evaluate an efficient countermeasure to strengthen SDN networks against fingerprinting. Our results demonstrate the effectiveness of our countermeasure in deterring fingerprinting attacks on SDN networks.
Figure S2 from Gene Copy Number Estimation from Targeted Next-Generation Sequencing of Prostate Cancer Biopsies: Analytic Validation and Clinical Qualification (2023)

&lt;p&gt;RB1 FISH from sample p.16.0 showing RB1 (red) and reference (green) showing a mixture of: hemizygously deleted cells (white arrows) and homozygously deleted cells (orange arrows).&lt;/p&gt;
Conversational Text-to-SQL: An Odyssey into State-of-the-Art and Challenges Ahead (2023)

Conversational, multi-turn, text-to-SQL (CoSQL) tasks map natural language utterances in a dialogue to SQL queries. State-of-the-art (SOTA) systems use large, pre-trained and finetuned language models, such as the T5-family, in conjunction with constrained decoding. With multi-tasking (MT) over coherent tasks with discrete prompts during training, we improve over specialized text-to-SQL T5-family models. Based on Oracle analyses over n-best hypotheses, we apply a query plan model and a schema linking algorithm as rerankers. Combining MT and reranking, our results using T5-3B show absolute accuracy improvements of 1.0% in exact match and 3.4% in execution match over a SOTA baseline on CoSQL. While these gains consistently manifest at turn level, context dependent turns are considerably harder. We conduct studies to tease apart errors attributable to domain and compositional generalization, with the latter remaining a challenge for multi-turn conversations, especially in generating SQL with unseen parse trees.
Cage DimericN-Acyl- andN-Acyloxy-4-aryl-1,4-dihydropyridines as First Representatives of a Novel Class of HIV-1 Protease Inhibitors (1999)

The synthesis of a series of novel cage dimeric N-acyl and N-acyloxy-4-aryl-1,4-dihydropyridines starting either from solid-state synthetic ester dimers or from monomeric 4-aryl-1,4-dihydropyridines is presented. Their biological evaluation as novel HIV-1 protease inhibitors showed the most active compounds to be 5c and 5i with inhibitory activities of 52% (50 microM) and 49% (25 microM), respectively. Within each series of N-acyl- and N-acyloxy derivatives NCOBz and NBoc groups were found to be the best substituents. Although they exhibiting only moderate activities these cage dimers hold promise as a class of novel non-peptidic HIV-1 protease inhibitors.
Inhibition of cyclooxygenase-2 activity impairs antibody production in human B cells and in mice infected with vaccinia virus (84.8) (2010)

Abstract Generation of protective humoral immune responses against vaccines depends on optimal production of antibodies by B lymphocytes. Non-steroidal anti-inflammatory drugs (NSAIDs) are used to curb undesirable symptoms of vaccination, including pain, fever and swelling. We previously demonstrated in B cells that cyclooxygenase-2 (Cox-2) is induced in response to both T-dependent and T-independent stimuli, including the TLR9 ligand CpG DNA, and that Cox-2 is crucial for antibody production. Expression of plasma cell transcriptional regulatory factors, including Blimp-1 and Xbp-1, were dependent on Cox-2 activity. Significantly fewer antibody secreting plasma cell precursors were generated in the presence of Cox-2 selective inhibitors, indicating that Cox-2 is essential for human B cell terminal differentiation. Cox-2 selective inhibitors were administered in vivo to determine the role of Cox-2 in a humoral immune response to live infection with vaccinia virus. Mice chronically treated with Cox-2 selective inhibitors produced less viral neutralizing IgG following live virus infection. Inhibition of Cox-2 resulted in a reduced frequency of IFN-γ producing T cells, indicating that T cell priming of B cells was attenuated. These data support the idea that impaired humoral immunity in the absence of Cox-2 activity can be dependent on both B cells and T cells and that the use of Cox-2 selective inhibitors have the potential to dampen humoral immunity to live virus infection and vaccines.
Automated load-independent cell library macromodeling for efficient and accurate waveform simulation (2002)

A novel gate-level macromodeling technique is presented. In an attempt to address the increasingly analog behavior of signals in semi-custom digital designs, the technique produces a linear transient macromodel capable of accurately predicting the gate output voltage waveform over a wide range of input and loading conditions. The macromodel is derived by analyzing SPICE generated voltage and current responses for a set of "extreme" operating conditions and is shown to exhibit good waveform prediction capability and average performance errors of approximately /spl plusmn/10%.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Selection of improved peptide ligases by yeast surface display (2012)

The ability to ligate synthetic peptides with high efficiency will be of tremendous value to the scientific community by enabling efficient labeling or assembly of proteins. Previously, we have engineered a first generation peptide ligase, called subtiligase, as a tool for semi‐protein synthesis, and for proteomics applications involving labeling N‐termini (N‐terminomics). Under conditions we use for N‐terminomics, subtiligase suffers from a low ligation efficiency. A second generation subtiligase was developed using phage display and a single catalytic turnover selection scheme. However, due to the binary nature of single turnover catalysis, it became difficult to select for enzymes with higher catalytic activities. Here we present a multiple turnover selection technology using yeast display whereby individual turnover events are accounted for by the ligation of a fluorophore‐tagged peptide. The advantages that yeast display provide are high‐copy number of enzymes and dual color fluorescence activated cell sorting for selection and normalization of multiple turnover events. This study provides a rare example of selecting for improved enzyme properties using yeast display. NIGMS 5R01GM081051
First observation of the decay B0→D0D¯K+0π− (2020)

The first observation of the decay ${B}^{0}\ensuremath{\rightarrow}{D}^{0}{\overline{D}}^{0}{K}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$ is reported using proton-proton collision data corresponding to an integrated luminosity of $4.7\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ collected by the LHCb experiment in 2011, 2012 and 2016. The measurement is performed in the full kinematically allowed range of the decay outside of the ${D}^{*\ensuremath{-}}$ region. The ratio of the branching fraction relative to that of the control channel ${B}^{0}\ensuremath{\rightarrow}{D}^{*\ensuremath{-}}{D}^{0}{K}^{+}$ is measured to be $\mathcal{R}=(14.2\ifmmode\pm\else\textpm\fi{}1.1\ifmmode\pm\else\textpm\fi{}1.0)%$, where the first uncertainty is statistical and the second is systematic. The absolute branching fraction of ${B}^{0}\ensuremath{\rightarrow}{D}^{0}{\overline{D}}^{0}{K}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$ decays is thus determined to be $\mathcal{B}({B}^{0}\ensuremath{\rightarrow}{D}^{0}{\overline{D}}^{0}{K}^{+}{\ensuremath{\pi}}^{\ensuremath{-}})=(3.50\ifmmode\pm\else\textpm\fi{}0.27\ifmmode\pm\else\textpm\fi{}0.26\ifmmode\pm\else\textpm\fi{}0.30)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}4}$, where the third uncertainty is due to the branching fraction of the control channel. This decay mode is expected to provide insights to spectroscopy and the charm-loop contributions in rare semileptonic decays.
Macrocycles Containing Five Pyrrole Subunits: The Iso-oxopentaphyrin System (1998)

Reaction of a 1,9-diformyl-5-dipyrroketone (11) with a tripyrrane (12) affords a novel pentapyrrolic macrocycle (13) characterized as an iso-oxopentaphyrin (λmax 787 nm). Along with the iso-oxopentaphyrin, small amounts of oxophlorin (20) and porphyrin (21) are also produced. Mechanistic implications are discussed.
Controlling floating-body effects for 0.13 μm and 0.10 μm SOI CMOS (2002)

The ultra-thin gate oxide required for the 0.13 /spl mu/m generation and beyond introduces a significant amount of gate-to-body tunneling current. The gate current modulates the body voltage and therefore the history effect. This paper discusses several methods to minimize the impact of gate current, which can cause excessive history effect in 0.10 /spl mu/m SOI CMOS. Our result demonstrates that the combination of high gate leakage and small junction capacitance can enhance circuit performance due to beneficial gate coupling. Ultra-low junction capacitance can be achieved by aggressive SOI thickness scaling, though, the proximity of source/drain extension and channel depletion to the buried oxide complicates device design and modeling.
Reinvestigation of the chemistry of arylcarbenes in polycrystalline alcohols at 77K. Secondary photochemistry of matrix-isolated carbenes (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReinvestigation of the chemistry of arylcarbenes in polycrystalline alcohols at 77K. Secondary photochemistry of matrix-isolated carbenesElisa. Leyva, Robert L. Barcus, and Matthew S. PlatzCite this: J. Am. Chem. Soc. 1986, 108, 24, 7786–7788Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://pubs.acs.org/doi/10.1021/ja00284a049https://doi.org/10.1021/ja00284a049research-articleACS PublicationsRequest reuse permissionsArticle Views115Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
IC‐P‐036: MRI validation of the NINDS‐CSN proposed neuropsychological assessment protocol for vascular cognitive impairment (2009)

In 2005, the NINDS-Canadian Stroke Network sponsored a workshop to develop epidemiological, pathological, experimental, neuropsychological and imaging standards for the assessment of vascular cognitive impairment (VCI). From this workshop, 60, 30 and 5-minute neuropsychological protocols were developed to assess cognitive function. The current study presents preliminary results on the validation of the 60-minute protocol using MRI measures of macro- and micro-structural integrity of white matter (WM) in patients with recent ischemic stroke. Patients 6 to 18 months post-ischemic stroke were tested on the cognitive assessment protocols and had MRIs of the brain. Macro-structural integrity of WM was assessed using a FLAIR pulse sequence with semi-automated assessment of WM hyperintensities using SABRE. Micro-structural integrity of WM was assessed using diffusion tensor imaging (DTI) determined fractional anisotropy (FA) of radiologically defined normal appearing white matter (NAWM). Relationship of imaging markers to neuropsychological performance measures was assessed in a series of regressions controlling for estimates of pre-morbid IQ. 21 ischemic stroke patients (mean age 69.7 + 11.9 year; mean Barthel score = 87.6 + 19.5; mean MMSE = 27.3 + 3.2) were tested and imaged. The average standardized performance on the 60 minute neuropsychological screening test for the patients was z = -1.5 (range -4.9 to 0.2). The sample's average volume of SABRE determined WM hyperintensities was 11.7 + 21.8 cm3 and NAWM FA was 0.32 + 0.04. Overall, pre-morbid IQ, WM hyperintensities and NAWM integrity significantly predicted performance on the 60-minute protocol (F[3,18] = 8.02, p = .002), accounting for approximately 62% of the shared variance. Higher volumes of WM hyperintensities and lower NAWM FA values were associated with poorer cognitive performance. NAWM integrity and WM hyperintensities independently improved the predictive model over the use of estimated pre-morbid IQ alone (R2 change 0.26 and 0.13 respectively, both p's < .05). These results provide preliminary support for the NINDS-CSN workshop proposed neuropsychological protocol for VCI. Both the volume of FLAIR determined WM hyperintensities and NAWM integrity significantly and independently predicted cognitive performance even while controlling for pre-morbid IQ. This ongoing project is supported by the NIH (NS057514).
Autoantibodies to Human Asialoglycoprotein Receptor in Autoimmune–Type Chronic Hepatitis (1990)

Autoantibodies to the human asialoglycoprotein receptor (anti-h-ASGPR) were studied with a solid-phase ELISA in the sera of 421 patients with inflammatory liver diseases, 288 patients with various other disorders and 31 controls. Anti-h-ASGPR were found predominantly in autoimmune chronic active hepatitis (44 of 88, 50%) and were closely related to inflammatory activity. In a subpopulation of these patients with untreated, biopsy-proven active disease or relapse, 15 of 17 were positive (88%). In contrast, only 11 of 204 patients (5.3%) with viral hepatitis were anti-h-ASGPR receptors-positive (chi 2 analysis; p less than 0.001). We also compared the occurrence of anti-h-ASGPR with antibodies to rabbit and rat asialoglycoprotein receptors in 352 sera. In contrast to the anti-human asialoglycoprotein receptor antibodies (3 of 107), anti-rabbit- or anti-rat-asialoglycoprotein receptor antibodies were found in 21 and 28 of 107 cases of viral hepatitis, indicating that different epitopes were recognized by these sera. In various other diseases anti-human asialoglycoprotein receptor antibodies were rarely found. Some sera from patients with connective-tissue diseases (8 of 73) and primary or secondary liver malignancies (6 of 55) exhibited anti-h-ASGPR. In autoimmune chronic active hepatitis the presence of anti-human asialoglycoprotein receptors did not correlate to other established autoantibody systems. Thus we conclude that anti-human asialoglycoprotein receptor antibodies can serve as diagnostic markers for inflammatory active cases of autoimmune chronic active hepatitis. Immune reactions to the asialoglycoprotein receptor, which is expressed on the hepatocellular membrane as a liver-specific antigen, might contribute to the pathogenesis of autoimmune chronic active hepatitis.
Resonant Josephson tunneling inS−I−S′-I-S multilayered devices (1999)

It was observed experimentally that the magnitude of the Josephson current through a single junction in the double-barrier ${\mathrm{N}\mathrm{b}/\mathrm{A}\mathrm{l}\ensuremath{-}\mathrm{A}\mathrm{l}\mathrm{O}}_{x}\ensuremath{-}{\mathrm{N}\mathrm{b}/\mathrm{A}\mathrm{l}\ensuremath{-}\mathrm{A}\mathrm{l}\mathrm{O}}_{x}\ensuremath{-}\mathrm{N}\mathrm{b}$ stack is lower than that for the whole device. This effect is explained by a model that takes into account Andreev reflection in the ${\mathrm{S}\ensuremath{-}\mathrm{I}\ensuremath{-}\mathrm{S}}^{\ensuremath{'}}$-I-S double-barrier stack, where S and ${\mathrm{S}}^{\ensuremath{'}}$ are superconductors and I is an insulator. The middle ${\mathrm{S}}^{\ensuremath{'}}$ layer is very thin (with the thickness of order the coherence length) and has reduced superconducting parameters as compared with the external S layers. The model predicts bound state levels in the middle electrode. The bound states provide an additional channel of Josephson tunneling which results in enhanced Josephson critical current density through the stack as compared with that for the single ${\mathrm{S}\ensuremath{-}\mathrm{I}\ensuremath{-}\mathrm{S}}^{\ensuremath{'}}$ junction.
Bridging the gap between high-throughput genetic and transcriptional data reveals cellular pathways responding to alpha-synuclein toxicity (2009)

Cells respond to stimuli by changes in various processes, including signaling pathways and gene&#13;\nexpression. Efforts to identify components of these responses increasingly depend on mRNA&#13;\nprofiling and genetic library screens, yet the functional roles of the genes identified by these assays&#13;\noften remain enigmatic. By comparing the results of these two assays across various cellular&#13;\nresponses, we found that they are consistently distinct. Moreover, genetic screens tend to identify&#13;\nresponse regulators, while mRNA profiling frequently detects metabolic responses. We developed&#13;\nan integrative approach that bridges the gap between these data using known molecular interactions,&#13;\nthus highlighting major response pathways. We harnessed this approach to reveal cellular pathways&#13;\nrelated to alpha-synuclein, a small lipid-binding protein implicated in several neurodegenerative&#13;\ndisorders including Parkinson disease. For this we screened an established yeast model for alphasynuclein&#13;\ntoxicity to identify genes that when overexpressed alter cellular survival. Application of&#13;\nour algorithm to these data and data from mRNA profiling provided functional explanations for many&#13;\nof these genes and revealed novel relations between alpha-synuclein toxicity and basic cellular&#13;\npathways.
Nonlinear Frameworks for Reversible and Pluripotent Wetting on Topographic Surfaces (2016)

Soft, ultrathin frameworks nonlinearly organized in tandem are presented to realize both reversible and pluripotent wetting on topographic surfaces. A design rule is introduced by establishing and proving the theoretical model upon hierarchical textures. Nonlinear frameworks can be conformally and reversibly wet upon complex topography in nature, thereby overcoming the wetting problems in previous conventional solid systems.
Idd9.2andIdd9.3Protective Alleles Function in CD4+ T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8+ T-Cells (2010)

Idd9 protective alleles are associated with reduced expansion of IGRP-specific CD8(+) T-cells. Intrinsic expression of protective Idd9 alleles in CD4(+) T-cells and nonlymphoid cells is required to achieve an optimal level of tolerance. Protective alleles in the Idd9.2 congenic subregion are required for the maximal reduction of islet-specific CD8(+) T-cells.
Thorough investigation of Si-nanocrystal memories with high-k interpoly dielectrics for sub-45nm node Flash NAND applications (2007)

In this paper we show for the 1st time that Silicon nanocrystal (Si-ncs) memories with high-k (HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> and HfAlO) interpoly dielectrics (IPD) can offer excellent behaviour in the Fowler-Nordheim regime, with great relevance for future sub-45 nm NAND memory generations. We significantly advance the state-of-the-art by showing a strict correlation between the different IPD properties and the performance obtained on memory transistors down to 90 nm gate lengths. In particular the results demonstrate that HfAlO IPDs combine the fast p/e and good 105 cycles endurance behaviour of HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and the long retention of Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> with no activation up to 125degC Then, in order to boost the memory window, we also integrated a hybrid Si-nc/SiN layer floating gate, with a HfAlO based IPD. It is shown that a 6V DeltaV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> can be achieved, with good retention and cycling behaviours.