gebhart/patrepeval huggingface dataset:
Développement préclinique et clinique des inhibiteurs de farnésyl transférase : perspectives en hématologie (2005)

Les inhibiteurs de farnesyl transferase (FTI) ont ete initialement concus sur la double constatation que les proteines Ras participent a l’oncogenese de nombreux cancers et que leur pouvoir transformant necessite leur lipidation post-traductionelle par farnesylation. Les etudes precliniques ont ete tres prometteuses en montrant que les FTI inhibent effectivement la transformation cellulaire et la croissance tumorale dans de nombreux modeles murins et humains. Ceci a conduit au developpement clinique rapide de ces molecules, avec des resultats plus contrastes temoignant d’une efficacite inconstante dans les tumeurs solides. La meilleure comprehension des mecanismes de leucemogenese, impliquant l’activation de ras et la deregulation des voies de signalisation MAPK et PI3K/Akt, a conduit au developpement des FTI dans les hemopathies malignes avec des resultats encourageants. Nous detaillons dans cette revue les resultats des principaux essais cliniques et nous discutons les principaux effets cellulaires (antiproliferatifs, pro-apoptotique, antiangiogenique) des FTI ainsi que leur(s) cible(s) potentielle(s). En effet, l’elucidation des bases biologiques de l’action antitumorale des FTI parait desormais indispensable afin de preciser au mieux leurs indications et d’optimiser leur utilisation clinique.
Supplementary File 12 from Genome-Wide Functional Synergy between Amplified and Mutated Genes in Human Breast Cancer (2023)

Supplementary File 12 from Genome-Wide Functional Synergy between Amplified and Mutated Genes in Human Breast Cancer
Ghost Imaging at the Free-Electron Laser FLASH (2021)

A classical ghost imaging experiment performed at the free-electron laser FLASH is presented. The possibility of image formation, a double bar in our case, in the beam that has never interacted with the sample is demonstrated.
The Semantics of Determiners (RLE Linguistics B: Grammar) (2014)

This book is a collection of linguistic and philosophical papers dealing with the semantic problems of determiners. The language under investigation is mostly English, although a few papers deal with French and German, and, to a lesser extent, with Dutch, Polish, Russian and Hebrew. The majority of the contributions focus on the semantics of the definite and indefinite articles, leading into discussions of anaphoricness, specificness, opacity and transparency, referentiality and attributiveness and genericness. The relation of the determiners to other parts of grammar, in particular relativisation and predication, is also investigated. Some attention is also given to quantifiers. In the spirit of pluralism, there is no single paradigm unifying all the papers, rather, the volume reflects elements of the Extended Standard Theory, Generative Semantics, Montague Grammar, (Gricean) Pragmatics and Speech Act Theory.
Persistent HIV Type 1 Seronegative Status Is Associated With Lower CD8+T-Cell Activation (2015)

We leveraged data from the Preexposure Prophylaxis Initiative (iPrEx), a global trial of preexposure chemoprophylaxis against human immunodeficiency virus type 1 (HIV-1) infection, to compare T-cell activation between those who remained negative for HIV-1 and those who became infected during the trial. The frequency of CD38(+)HLA-DR(+) CD8(+) T cells was greater in those who seroconverted, relative to the frequency in those who remained uninfected (1.30% vs 0.82%, respectively; P = .005). This translated to an odds ratio of 4.26 (95% confidence interval, 1.54-11.78) for the association between CD8(+) T-cell activation and infection with HIV-1. T-cell activation may be a biomarker for elevated HIV-1 infection risk.
Abstract 4369: Eradication of chemotherapy-resistant CD44+ human ovarian cancer stem cells in C.B-17/SCID mice by intraperitoneal administration of Clostridium Perfringens Enterotoxin (CPE) (2011)

Abstract Emerging evidence has suggested that the capability to sustain tumor formation, growth and resistance to chemotherapy in ovarian as well as other human malignancies, exclusively resides in a small proportion of tumor cells termed cancer stem cells (CSC). If this hypothesis is correct, different therapeutic approaches need to be considered for the elimination of the cancer stem cell population. During the characterization of CD44+ ovarian CSC we found a high expression of the genes encoding for claudin-4. Because this tight junction protein is the natural high affinity receptor for the cytotoxic effect of Clostridium Perfringens Enterotoxin (CPE), we have extensively investigated the sensitivity of ovarian CSC to CPE treatment in vitro and in vivo. We report that CD44+ ovarian CSC expressed claudin-4 gene at significantly higher levels when compared to matched autologous CD44- ovarian cancer cells and, regardless of their higher resistance to chemotherapeutic agents, died within 1 hr to the exposure to 1.0 μg/mL of CPE in vitro. Importantly, multiple intraperitoneal (i.p.) administration of sublethal doses of CPE in SCID mouse harboring established xenografts of chemotherapy resistant CD44+ ovarian CSC had a significant inhibitory effect on tumor progression leading to the cure and/or long term survival of all treated animals (p = 0.001). CPE may represent an unconventional, potentially highly effective strategy to eradicate chemotherapy resistant CSC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4369. doi:10.1158/1538-7445.AM2011-4369
ChemInform Abstract: METAL EXCHANGE KINETICS OF BIS(SALICYLALDIMINATO)COPPER(II) COMPLEXES IN CHLOROFORM, I. EFFECT OF DONOR OXYGEN ELECTRON DENSITY (1976)

Abstract Der Cu‐ Austausch zwischen den Bis‐[salicylaldirninato]‐Cu(II)‐Komplexen (I) und dem Cu(II)‐ acetat‐Komplex (II) wird im Temperaturbereich 0‐25°C durch Isotopenaustausch untersucht, um den Einfluß von Substituenten in 3‐ und 5‐Stellung zu ermitteln.
Supplementary Figure 5 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy (2023)

&lt;p&gt;PDF file - 2MB, Modified STAT3 decoys abrogate STAT3 target gene expression in vitro&lt;/p&gt;
Predicting an Optimal Outcome After Radical Prostatectomy: The Trifecta Nomogram (2008)

A trifecta (optimal) outcome can be achieved in most men undergoing radical prostatectomy. The nomogram permits patients to estimate preoperatively their likelihood of an optimal outcome after radical prostatectomy.
Data from Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: <i>In Vitro</i> and <i>In Vivo</i> Preclinical Models (2023)

&lt;div&gt;Abstract&lt;p&gt;The SWI/SNF complex is a major regulator of gene expression and is increasingly thought to play an important role in human cancer, as evidenced by the high frequency of subunit mutations across virtually all cancer types. We previously reported that in preclinical models, malignant rhabdoid tumors, which are deficient in the SWI/SNF core component INI1 (SMARCB1), are selectively killed by inhibitors of the H3K27 histone methyltransferase EZH2. Given the demonstrated antagonistic activities of the SWI/SNF complex and the EZH2-containing PRC2 complex, we investigated whether additional cancers with SWI/SNF mutations are sensitive to selective EZH2 inhibition. It has been recently reported that ovarian cancers with dual loss of the redundant SWI/SNF components SMARCA4 and SMARCA2 are characteristic of a rare rhabdoid-like subtype known as small-cell carcinoma of the ovary hypercalcemic type (SCCOHT). Here, we provide evidence that a subset of commonly used ovarian carcinoma cell lines were misdiagnosed and instead were derived from a SCCOHT tumor. We also demonstrate that tazemetostat, a potent and selective EZH2 inhibitor currently in phase II clinical trials, induces potent antiproliferative and antitumor effects in SCCOHT cell lines and xenografts deficient in both SMARCA2 and SMARCA4. These results exemplify an additional class of rhabdoid-like tumors that are dependent on EZH2 activity for survival. &lt;i&gt;Mol Cancer Ther; 16(5); 850–60. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Stone tracking with time-reversal techniques (1998)

Time reversal of ultrasonic fields allows a very efficient approach to focusing pulsed ultrasonic waves through lossless inhomogeneous media. Time reversal mirrors (TRM) are made of large transducer arrays, allowing the incident acoustic field to be sampled, time reversed and reemitted. Time reversal processing permits a choice of any temporal window to be time reversed, allowing operation in an iterative mode. In multitarget media, this process converges on the most reflective target, i.e., the dominant scatterer. The time reversal process is applied to track, in real time a moving gall bladder or kidney stone embedded in its surrounding medium. The feasibility of adaptative beam forming techniques to track the stone during a lithotripsy treatment is investigated. It is shown that TRM allows sharp focusing on one bright point of the stone. Once the bright point is selected, a time of flight profile is determined and used in a least-mean-square method to calculate the spatial coordinates of the stone. Stone trajectories can be tracked by this technique at 30 Hz.
Initial repair strengths of two methods for acute medial collateral ligament injuries of the elbow (2007)

Abstract The purposes of this study were to compare the initial repair strength of the medial collateral ligament (MCL) of the elbow using trans‐osseous sutures and suture anchor methods and to determine the effect of repair pretensioning. Twelve, fresh‐frozen upper extremities (66 ± 5 years) were mounted in a valgus‐loading system. MCL repairs were performed using trans‐osseous suture and suture anchor methods with 20 N or 40 N pretensioning. A cyclic (0.5 Hz), valgus 40 N load was applied 12 cm distal to the elbow axis of flexion. The load was increased by 10 N every 200 cycles until a length increase of 5 mm or catastrophic failure of the repair occurred. Repairs pretensioned with 40 N endured a significantly higher number of cycles and failed at higher loads than those pretensioned with 20 N ( p &lt; 0.05). No difference was found in the cycles or load to failure between trans‐osseous sutures and suture anchors ( p &gt; 0.05). A higher magnitude of pretensioning of MCL repairs was found to increase initial repair strength suggesting that pretensioning should be performed clinically. Despite the comparable failure loads of the trans‐osseous suture and suture anchor methods, the failure mechanism differed between the two techniques. The suture anchors usually failed catastrophically when the sutures broke as they passed through the anchor eyelet, while the trans‐osseous sutures gradually elongated to the defined failure length by stretching and sliding through the ligament. The use of different suture anchors, suture sizes, or suture materials would likely influence the findings of this study and should be considered when applying these findings clinically. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:612–616, 2007
BSIM2EKV: un outil pour la conversion automatique des paramètres du modèle BSIM aux paramètres du modèle EKV (2004)

LEG1
The effect of microstructures on the electrical properties of Cr–Si–C thin film resistors (2022)

Abstract The resistivity and temperature coefficient of the resistance (TCR) of Cr–Si–C films are investigated with various microstructures changed by annealing up to 1000 °C. The resistivity shows an abrupt change when the annealing temperature is between 450 °C and 600 °C, reaching its peak at 540 °C. In contrast, the TCR increases continuously and shifts from negative to positive values at around 510 °C. The crystal phase, microstructure and composition of the Cr–Si–C films are analyzed using X-ray diffraction, scanning transmission electron microscopy, and energy dispersive X-ray spectroscopy, respectively. The abrupt change in resistivity and TCR values above 450 °C annealing are attributed to the growth of Cr silicide crystals inside the amorphous Cr–Si–C film. The relationship between electrical properties and microstructures of Cr–Si–C film is discussed with the electrical current path model based on physical analysis.
The Information Complexity of Learning Tasks, their Structure and their\n Distance (2019)

We introduce an asymmetric distance in the space of learning tasks, and a\nframework to compute their complexity. These concepts are foundational for the\npractice of transfer learning, whereby a parametric model is pre-trained for a\ntask, and then fine-tuned for another. The framework we develop is\nnon-asymptotic, captures the finite nature of the training dataset, and allows\ndistinguishing learning from memorization. It encompasses, as special cases,\nclassical notions from Kolmogorov complexity, Shannon, and Fisher Information.\nHowever, unlike some of those frameworks, it can be applied to large-scale\nmodels and real-world datasets. Our framework is the first to measure\ncomplexity in a way that accounts for the effect of the optimization scheme,\nwhich is critical in Deep Learning.\n
A new spectral approach to modeling charge trapping/detrapping in NAND Flash memories (2014)

We present a semi-analytical model for the description of charge trapping and detrapping phenomena occurring during cycling and idle periods in NAND Flash memories. The model is based on a statistical distribution of detrapping time constants that is affected by the composition of cycles and idle periods and accounts for charge discreteness, statistical charge capture and emission and statistical distribution of the threshold-voltage shift due to single detrapping events. The model can reproduce the experimental data under different conditions and allows to develop and monitor accelerated schemes able to mimic realistic on-field usage of the memory device.
A new algorithm for detection and verification of ventricular arrhythmia from the left ventricular pressure waveform (2002)

The new algorithm for detection of cardiac arrhythmic beats by analyzing the left ventricular pressure signal is presented. The algorithm analyzes changes in beat rate, peak-to-peak amplitude and width of the LVP beat cycles, to identify arrhythmic beats. The algorithm allows rhythm analysis of patients with highly distorted ECG, and can also be used in conjunction with ECG based algorithms to improve performance. Testing the algorithm, on files from heart failure patients treated with cardiac contractility modulation therapy (CCM), showed a total detection failure of 1%.
Charge‐tunable polymers as reversible and recyclable flocculants for the dewatering of microalgae (2014)

Microalgae-derived biofuels have potential advantages over other renewable, crop-based resources; however, large-scale production is not currently economical due, in part, to challenges in the harvesting step. In this article, we present a novel approach for the dewatering and harvesting of microalgae using flocculants that can be recovered and recycled. Polyampholytes with molecular charges dependent upon pH (ranging from net positively- to net negatively-charged) are used as a model flocculant system and provide reversible electrostatic interactions with the negatively-charged algal cells. These pH-dependent properties allow the polyampholytic flocculants to efficiently desorb from concentrated biomass and, unlike most commercial flocculants that have permanently charged functionalities, be recovered and recycled for further dewatering processes. The behavior of the model polyampholytic flocculants is characterized for the dewatering of Chlorella vulgaris (UTEX 395). The reversible and recyclable flocculants achieve >99% flocculation efficiencies, are recovered at more than 98 wt% yields after biomass dewatering, and can be recycled over five times for flocculation.
Stereochemical Analysis of Diastereomeric 1,3‐Bis(adenosine‐5′‐O‐phosphorothioyl)glycerols (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Thrombocytopenia and the effect of platelet transfusions on the occurrence of intracranial hemorrhage in patients with acute leukemia – a nested case-control study (2020)

We designed a study to describe the incidence of intracranial hemorrhage according to severity and duration of thrombocytopenia and to quantify the associations of platelet transfusions with intracranial hemorrhage in patients with acute leukemia. In this case-control study nested in a cohort of 859 leukemia patients, cases (n = 17) were patients diagnosed with intracranial hemorrhage who were matched with control patients (n = 55). We documented platelet counts and transfusions for seven days before the intracranial hemorrhage in cases and in a "matched" week for control patients. Three measures of platelet count exposure were assessed in four potentially important time periods before hemorrhage. Among these leukemia patients, we observed the cumulative incidence of intracranial hemorrhage of 3.5%. Low platelet counts were, especially in the three to seven days preceding intracranial hemorrhage, associated with the incidence of intracranial hemorrhage, although with wide confidence intervals. Platelet transfusions during the week preceding the hemorrhage were associated with higher incidences of intracranial hemorrhage; rate ratios (95% confidence interval) for one or two platelet transfusions and for more than two transfusions compared with none were 4.04 (0.73 to 22.27) and 8.91 (1.53 to 51.73) respectively. Thus, among acute leukemia patients, the risk of intracranial hemorrhage was higher among patients with low platelet counts and after receiving more platelet transfusions. Especially, the latter is likely due to clinical factors leading to increased transfusion needs.
Increasing Splitting Ratio of 10Gb/s-Class PONs by Using FW-DMF that Acts as Low Loss Splitter for Upstream and Conventional Splitter for Downstream (2014)

A simple optical splitter, a dual-mode fiber (DMF) is connected to a funnel-shaped waveguide (FW), is proposed and the feasibility of a 128-way 10G-EPON system using a 1 x 16 prototype is experimentally demonstrated.
Photochemistry of (dioxygen)bis(triphenylphosphine)palladium in chlorinated hydrocarbon solvents (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemistry of (dioxygen)bis(triphenylphosphine)palladium in chlorinated hydrocarbon solventsDonald Deal and Jeffrey I. ZinkCite this: Inorg. Chem. 1981, 20, 11, 3995–3997Publication Date (Print):November 1, 1981Publication History Published online1 May 2002Published inissue 1 November 1981https://pubs.acs.org/doi/10.1021/ic50225a080https://doi.org/10.1021/ic50225a080research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analysis of protease activity in human otitis media (1998)

Chronic otitis media is a common problem associated with a nonintact tympanic membrane frequently involving Staphylococcus aureus and Pseudomonas aeruginosa. The virulence of Pseudomonas bacteria is related to the production of two matrix metalloproteinases, elastase and alkaline protease. Serine proteases, such as neutrophil elastase, are produced by the host inflammatory response. These proteases are thought to contribute to tissue destruction and assist bacterial invasion during infection. This preliminary study was done to identify protease activity in otorrhea samples from patients with otitis media and a nonintact tympanic membrane and to examine the ability of selective protease inhibitors to decrease protease activity. Ilomostat (galardin) is a synthetic, specific inhibitor of matrix metalloproteinases including P. aeruginosa elastase and alkaline protease, whereas alpha1-antitrypsin inhibits serine proteases including neutrophil elastase. Samples were collected and cultured from 20 patients with otorrhea resulting from tympanic membrane perforations or pressure-equalization tubes. A protease assay that used azocasein as the substrate was used to quantify protease activity, with and without addition of selective protease inhibitors. Cultures revealed P. aeruginosa alone in 7 samples, P. aeruginosa plus other organisms in 10, and S. aureus alone in 3. Protease activity was detected in 15 (75%) of the samples. A statistically significant (p < 0.05) decrease in protease activity was seen with the addition of alpha1-antitrypsin or Ilomostat plus alpha1-antitrypsin, but not with Ilomostat alone. Analyzing the 10 samples with the highest protease activity, a statistically significant decrease in activity was seen with Ilomostat or alpha1-antitrypsin alone and with both Ilomostat and alpha1-antitrypsin together. Bacteriologic type, source of sample, age and gender of the subject, and duration of infection were not significantly related to protease activity. This is the first study to quantify protease activity and inhibition by selective protease inhibitors in human otorrhea. Protease inhibitors effectively decrease protease activity in most cases and in addition to standard antibiotic therapy might prove beneficial in the treatment of otitis media with a nonintact tympanic membrane. This study supports future clinical investigations into the role of proteases and inhibition of protease activity in the treatment of otitis media.