gebhart/patrepeval huggingface dataset:
Probing the surface polarity of inorganic oxides using merocyanine-type dyes derived from barbituric acid (2011)

The solid state complexes, solvatochromic and acidochromic behaviour of four merocyanine-type dyes derived from barbituric and thiobarbituric acid and their use as solvatochromic probe molecules for coloured surfaces are described. The dyes were obtained by condensation reaction of barbituric, N-methylbarbituric, N,N′-dimethylbarbituric and thiobarbituric acid with 4-N,N-dimethylaminocinnamaldehyde. The dyes were characterised by means of liquid and solid state NMR techniques (1H MAS NMR, 1H–1H DQ MAS NMR, 13C CPMAS NMR), single-crystal X-ray analysis, UV/vis and IR measurements. The solvatochromism has been investigated in 43 solvents and interpreted in terms of Kamlet–Taft parameters α, β, and π*. Altogether, the solvatochromic properties of these four dyes were determined mainly by the hydrogen bond donating (HBD) ability and the polarisability/dipolarity of a solvent. The interactions of the dyes with oxidic and metal surfaces were studied. Their perichromic behaviour was compared with that of established solvatochromic dyes for the determination of α, β, and π*, namely dicyano-bis-(1,10-phenanthroline)-iron(II)-complex (1), 3-(4-amino-3-methylphenyl)-7-phenyl-benzo-[1,2-b:4,5-b′]-difuran-2,6-dione (2) and 4-tert-butyl-2-(dicyanomethylene)-5-[4-(diethylamino)benzylidene]-Δ3-thiazoline (3). The barbituric acid dyes were used to probe the surface polarity of coloured oxides like tungsten(VI) oxide and iron(III) oxide. The interactions between the dyes and metals like zinc and aluminium were also investigated.
RF CMOS Oscillators for Modern Wireless Applications (2019)

While mobile phones enjoy the largest production volume ever of any consumer electronics products, the demands they place on radio-frequency (RF) transceivers are particularly aggressive, especially on integration with digital processors, low area, low power consumption, while being robust against process-voltage-temperature variations. Since mobile terminals inherently operate on batteries, their power budget is severely constrained. To keep up with the ever increasing data-rate, an ever-decreasing power per bit is required to maintain the battery lifetime. The RF oscillator is the second most power-hungry block of a wireless radio (after power amplifiers). Consequently, any power reduction in an RF oscillator will greatly benefit the overall power efficiency of the cellular transceiver. Moreover, the RF oscillators' purity limits the transceiver performance. The oscillator's phase noise results in power leakage into adjacent channels in a transmit mode and reciprocal mixing in a receive mode. On the other hand, the multi-standard and multi-band transceivers that are now trending demand wide tuning range oscillators. However, broadening the oscillator’s tuning range is usually at the expense of die area (cost) or phase noise. The main goal of this book is to bring forth the exciting and innovative RF oscillator structures that demonstrate better phase noise performance, lower cost, and higher power efficiency than currently achievable. Technical topics discussed in RF CMOS Oscillators for Modern Wireless Applications include:  Design and analysis of low phase-noise class-F oscillators Analyze a technique to reduce 1/f noise up-conversion in the oscillators Design and analysis of low power/low voltage oscillators Wide tuning range oscillators Reliability study of RF oscillators in nanoscale CMOS
Laser Scattering Induced Holograms in Lithium Niobate (1974)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text R. Magnusson and T. K. Gaylord, "Laser Scattering Induced Holograms in Lithium Niobate," Appl. Opt. 13, 1545_1-1548 (1974) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Measurement of Shear Elastic Moduli in Quasi-Incompressible Soft Solids (2008)

Recently a nonlinear equation describing the plane shear wave propagation in isotropic quasi‐incompressible media has been developed using a new expression of the strain energy density, as a function of the second, third and fourth order shear elastic constants (respectively μ, A, D) [1]. In such a case, the shear nonlinearity parameter βs depends only from these last coefficients. To date, no measurement of the parameter D have been carried out in soft solids. Using a set of two experiments, acoustoelasticity and finite amplitude shear waves, the shear elastic moduli up to the fourth order of soft solids are measured. Firstly, this theoretical background is applied to the acoustoelasticity theory, giving the variations of the shear wave speed as a function of the stress applied to the medium. From such variations, both linear (μ) and third order shear modulus (A) are deduced in agar‐gelatin phantoms. Experimentally the radiation force induced by a focused ultrasound beam is used to generate quasi‐plane linear shear waves within the medium. Then the shear wave propagation is imaged with an ultrafast ultrasound scanner. Secondly, in order to give rise to finite amplitude plane shear waves, the radiation force generation technique is replaced by a vibrating plate applied at the surface of the phantoms. The propagation is also imaged using the same ultrafast scanner. From the assessment of the third harmonic amplitude, the nonlinearity parameter βS is deduced. Finally, combining these results with the acoustoelasticity experiment, the fourth order modulus (D) is deduced. This set of experiments provides the characterization, up to the fourth order, of the nonlinear shear elastic moduli in quasi‐incompressible soft media. Measurements of the A moduli reveal that while the behaviors of both soft solids are close from a linear point of view, the corresponding nonlinear moduli A are quite different. In a 5% agar‐gelatin phantom, the fourth order elastic constant D is found to be 30±10 kPa.
Interpolation and channel tracking based receivers for coherent Mary-PSK modulations (2003)

This paper investigates decision-directed tracking and interpolation based channel estimation techniques for pilot assisted coherent Mary-PSK modulations. A Wiener filter based interpolation approach is compared with Kalman-based channel trackers. An enhancement to the decision directed approach that exploits the pilot symbols is proposed. The performance of the proposed receiver is compared with the performance of a receiver that uses channel interpolation for a variety of mobile speeds and different levels of PSK modulations. It is shown that although the proposed channel tracker improves the performance of the conventional channel trackers considerably, the interpolation based approaches performs better than the decision-directed tracking based approaches.
NUMERICAL CALCULATION OF FLOW AND MIXING IN VERTICAL BOUNDARY SURFACE OF DENSITY (1999)

A numerical model is one of the useful measures to predict the characteristics of the environmental systems on the interface of different density water. In the last few years, some models were already proposed to calculate each problems like flow in the stratified closed water systems and the saltwedge, and realized beneficial results. However, these models also have some defects. For example, turbulent models are sometimes difficult to use actually because of its theoreticalcomplexity, and simple two-dimensional models can not calculate so accurately. So in this paper, the new two-dimensional numerical model is proposed, which use CIP-scheme in the calculation of advection phase, in order to calculate density flow more accurately without using complicated models, and its availability is confirmed by the comparison between the results of the calculation and that of the experiment under the same condition.
Representation and reasoning for DAML-based policy and domain services in KAoS and nomads (2003)

To increase the assurance with which agents can be deployed in operational settings, we have been developing the KAoS policy and domain services. In conjunction with Nomads strong mobility and safe execution features, KAoS services and tools allow for the specification, management, conflict resolution, and enforcement of DAML-based policies within the specific contexts established by complex organizational structures. In this paper, we will discuss results, issues, and lessons learned in the development of these representations, tools, and services and their use in military and space applications.
The Future of Work(places) (2019)

While the shift to on-demand labor may foster greater control over one's employment in some ways, it has removed much of the benefits that come with consistently working in shared physical spaces. Working in physical spaces allow opportunities for social support, long-term growth, and stability. The goal of this workshop is to facilitate a discussion around how physical spaces and online technologies influence each other in on-demand work. We plan to invite a diverse group of stakeholders, including researchers studying these topics, grassroots organizers who can represent and voice the concerns of their respective worker communities, and designers of on-demand work platforms. Discussion and ideas generated from this workshop will be archived online and made available to the larger research community and the general public.
Formation of Tetrahydrofurano-, Aryltetralin, and Butyrolactone Norlignans through the Epoxidation of 9-Norlignans (2020)

Epoxidation of the C=C double bond in unsaturated norlignans derived from hydroxymatairesinol was studied. The intermediate epoxides were formed in up to quantitative conversions and were readily further transformed into tetrahydrofuran, aryltetralin, and butyrolactone products-in diastereomeric mixtures-through ring-closing reactions and intramolecular couplings. For epoxidation, the classical Prilezhaev reaction, using stoichiometric amounts of <i>meta</i>-chloroperbenzoic acid (<i>m</i>CPBA), was used. As an alternative method, a catalytic system using dimeric molybdenum-complexes [MoO<sub>2</sub>L]<sub>2</sub> with ONO- or ONS-tridentate Schiff base ligands and aqueous <i>tert</i>-butyl hydroperoxide (TBHP) as oxidant was used on the same substrates. Although the epoxidation was quantitative when using the Mo-catalysts, the higher temperatures led to more side-products and lower yields. Kinetic studies were also performed on the Mo-catalyzed reactions.
PRC2 direct transfer from G-quadruplex RNA to dsDNA has implications for RNA-binding chromatin modifiers (2023)

The chromatin-modifying enzyme, Polycomb Repressive Complex 2 (PRC2), deposits the H3K27me3 epigenetic mark to negatively regulate expression at numerous target genes, and this activity has been implicated in embryonic development, cell differentiation, and various cancers. A biological role for RNA binding in regulating PRC2 histone methyltransferase activity is generally accepted, but the nature and mechanism of this relationship remains an area of active investigation. Notably, many in vitro studies demonstrate that RNA inhibits PRC2 activity on nucleosomes through mutually antagonistic binding, while some in vivo studies indicate that PRC2's RNA-binding activity is critical for facilitating its biological function(s). Here we use biochemical, biophysical, and computational approaches to interrogate PRC2's RNA and DNA-binding kinetics. Our findings demonstrate that PRC2-polynucleotide dissociation rates are dependent on the concentration of free ligand, indicating the potential for direct transfer between nucleic acid ligands without a free-enzyme intermediate. Direct transfer explains the variation in previously reported dissociation kinetics, allows reconciliation of prior in vitro and in vivo studies, and expands the potential mechanisms of RNA-mediated PRC2 regulation. Moreover, simulations indicate that such a direct transfer mechanism could be obligatory for RNA to recruit proteins to chromatin.
Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington's disease and mouse models (2012)

Cannabinoid receptor 1 (CB(1) receptor) controls several neuronal functions, including neurotransmitter release, synaptic plasticity, gene expression and neuronal viability. Downregulation of CB(1) expression in the basal ganglia of patients with Huntington's disease (HD) and animal models represents one of the earliest molecular events induced by mutant huntingtin (mHtt). This early disruption of neuronal CB(1) signaling is thought to contribute to HD symptoms and neurodegeneration. Here we determined whether CB(1) downregulation measured in patients with HD and mouse models was ubiquitous or restricted to specific striatal neuronal subpopulations. Using unbiased semi-quantitative immunohistochemistry, we confirmed previous studies showing that CB(1) expression is downregulated in medium spiny neurons of the indirect pathway, and found that CB(1) is also downregulated in neuropeptide Y (NPY)/neuronal nitric oxide synthase (nNOS)-expressing interneurons while remaining unchanged in parvalbumin- and calretinin-expressing interneurons. CB(1) downregulation in striatal NPY/nNOS-expressing interneurons occurs in R6/2 mice, Hdh(Q150/Q150) mice and the caudate nucleus of patients with HD. In R6/2 mice, CB(1) downregulation in NPY/nNOS-expressing interneurons correlates with diffuse expression of mHtt in the soma. This downregulation also occludes the ability of cannabinoid agonists to activate the pro-survival signaling molecule cAMP response element-binding protein in NPY/nNOS-expressing interneurons. Loss of CB(1) signaling in NPY/nNOS-expressing interneurons could contribute to the impairment of basal ganglia functions linked to HD.
Supplementary methods from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma (2023)

&lt;p&gt;Supplementary file containing the supplementary methods&lt;/p&gt;
Tristetraprolin Regulates TH17 Cell Function and Ameliorates DSS-Induced Colitis in Mice (2020)

T<sub>H</sub>17 cells have been extensively investigated in inflammation, autoimmune diseases, and cancer. The precise molecular mechanisms for T<sub>H</sub>17 cell regulation, however, remain elusive, especially regulation at the post-transcriptional level. Tristetraprolin (TTP) is an RNA-binding protein important for degradation of the mRNAs encoding several proinflammatory cytokines. With newly generated T cell-specific TTP conditional knockout mice (CD4<sup>Cre</sup>TTP<sup>f/f</sup>), we found that aging CD4<sup>Cre</sup>TTP<sup>f/f</sup> mice displayed an increase of IL-17A in serum and spontaneously developed chronic skin inflammation along with increased effector T<sub>H</sub>17 cells in the affected skin. TTP inhibited T<sub>H</sub>17 cell development and function by promoting IL-17A mRNA degradation. In a DSS-induced colitis model, CD4<sup>Cre</sup>TTP<sup>f/f</sup> mice displayed severe colitis and had more T<sub>H</sub>17 cells and serum IL-17A compared with wild-type mice. Furthermore, neutralization of IL-17A reduced the severity of colitis. Our results reveal a new mechanism for regulating T<sub>H</sub>17 function and T<sub>H</sub>17-mediated inflammation post-transcriptionally by TTP, suggests that TTP might be a novel therapeutic target for the treatment of T<sub>H</sub>17-mediated diseases.
Application of temporary inflow control of the Glissonean pedicle method provides a safe and easy technique for totally laparoscopic hemihepatectomy by Glissonean approach (2017)

The Glissonian approach, due to its simplicity of procedure, is a technical procedure widely used in open hepatectomy. However, it is not easily applicable in the setting of the total laparoscopic approach because of movement restriction. We herein propose a new and simple method of performing hemihepatectomy by Glissonian approach called temporary inflow control of the Glissonian pedicle (TICGL) technique. Dissection of the Glisson pedicle from the liver parenchyma is done until the posterior margin of the pedicle is visualized, and is clamped with bulldog clamps. Encircling the pedicle is not necessary. Resection of the liver parenchyma is performed under inflow control of the resected side liver providing less bleeding. After sufficient resection is done so that the whole Glissonian pedicle structures are visualized, the pedicle is encircled, often very easily without the fear of bleeding from the posterior side of the pedicle, which is a common problem when encircling is done before parenchymal resection. The staplers may then be applied safely without injuring the major hepatic veins since they have been already exposed. Stapling is done while the tape is retracted toward the contralateral side. This retraction prevents injury or stricture of the contralateral Glissonian pedicle branch. The remnant liver parenchyma is resected and hepatectomy finalized. The TICGL technique provides a safe and easy way of performing major hemihepatectomies, not only by expert laparoscopic surgeons but by less experienced surgeons. It can therefore become a standard method of performing hemihepatectomy by Glissonian approach.
Movie S1 Vehicle from Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis (2023)

&lt;p&gt;Movie S1 Vehicle. 690 melanoma cells seeded on thick Col-I gel and treated with vehilce for 24h.&lt;/p&gt;
A novel machine interface for scaled telesurgery (2004)

We have developed a system architecture that will allow a surgeon to employ direct hand-eye coordination to conduct medical procedures in a remote microscopic environment. In this system, a scaled real-time video image of the workspace of a small robotic arm, taken from a surgical microscope camera, is visually superimposed on the natural workspace of a surgeon via a half-silvered mirror. The robot arm holds a small tool, such as a microsurgical needle holder or microsurgical forceps, and the surgeon grasps a second tool connected to a position encoder, in this case a second robot arm. The views of the local and remote environments are superimposed such that the tools in the local and remote environments are visually merged. The position encoder and small robot arm are linked such that movement of the tool by the operator produces scaled-down movement by the small robot tool. To the surgeon, it seems that his hands and the tool he or she is holding is moving and interacting with the remote environment, which is really microscopic and at a distance. Our current work focuses on using a position-controlled master-slave robot linkage of two 3 degree of freedom haptic devices, and we are pursuing the use of a 6-to-7 degree of freedom master-slave linkage to produce more realistic interaction.
Bioactive Phenolic Compounds of Soybean (Glycine max cv. Merit): Modifications by Different Microbiological Fermentations (2012)

In this work, the effect of solid-substrate fermentation with Aspergillus oryzae, Rhizopus oryzae and Bacillus subtilis of soybean seeds on bioactive phenolic compounds was studied. Among the analysed sample extracts several phenolic compounds, hydroxybenzoics, hydroxycinnamics and fl avonoids, such as fl avonols, fl avanones, isofl avones were identifi ed by HPLC-DAD-ESI/MS. The results obtained indicate that fermentation process carried out in seeds inoculated with different microorganisms produced signifi cant changes in fl avonoids and phenolic acids contents. A signifi cant increase in the content of phenolic acids was observed in the samples fermented with the different microorganisms with respect to soybean without fermentation and fermented naturally. Fermentation process produced also important changes in fl avonoids compounds, with a signifi cant formation in isofl avone aglycone contents such as daidzein, glycitein and genistein as a consequence of glucosidase activity of microorganism in this process, showing signifi cant differences (p<0.05) with respect to control. Therefore, this process was shown to be a good way to increase the phenolic content of soybean, which could confer health-promoting effects.
The immunopathology of acute experimental allergic encephalomyelitis induced with myelin proteolipid protein. T cell receptors in inflammatory lesions (1992)

To determine whether there is predominance of T cells expressing a particular TCR V beta chain in the inflammatory lesions of an autoimmune disease model, TCR expression was analyzed in central nervous system (CNS) tissues of mice with experimental allergic encephalomyelitis (EAE). Acute EAE was induced in SJL/J mice either by sensitization with a synthetic peptide corresponding to myelin proteolipid protein residues 139-151 or by adoptive transfer of myelin proteolipid protein peptide 139-151-specific encephalitogenic T cell clones. Mice were killed when they showed clinical signs of EAE or by 40 days after sensitization or T cell transfer. Cryostat CNS and lymphoid tissue sections were immunostained with a panel of mAb to T cell markers and proportions of stained cells were counted in inflammatory foci. In mice with both actively induced and adoptively transferred EAE, infiltrates consisted of many CD3+, TCR alpha beta+, and CD4+ cells, fewer CD8+ cells, and small numbers of TCR gamma delta+ cells. Approximately 30% of CD45+ leukocytes in the inflammatory foci were T cells. Cells expressing TCR V beta 2, 3, 4, 6, 7 and 14 were detected in the infiltrates, whereas TCR V beta 8 and 11, which that are deleted in SJL mice, were absent. When EAE was induced by transfer of T cell clones that use either V beta 2, 6, 10, or 17, there was also a heterogeneous accumulation of T cells in the lesions. Similar proportions of TCR V beta+ and gamma delta+ cells were detected in EAE lesions and in the spleens of the mice. Thus, at the time that clinical signs are present in acute EAE, peripherally derived, heterogeneous TCR V beta+ cells are found in CNS lesions, even when the immune response is initiated to a short peptide Ag or by a T cell clone using a single TCR V beta.
Detection of the tSZ effect with the NIKA camera (2013)

We present the first detection of the thermal Sunyaev-Zel'dovich (tSZ) effect from a cluster of galaxies performed with a KIDs (Kinetic Inductance Detectors) based instrument. The tSZ effect is a distortion of the black body CMB (Cosmic Microwave Background) spectrum produced by the inverse Compton interaction of CMB photons with the hot electrons of the ionized intra-cluster medium. The massive, intermediate redshift cluster RX J1347.5-1145 has been observed using NIKA (New IRAM KIDs arrays), a dual-band (140 and 240 GHz) mm-wave imaging camera, which exploits two arrays of hundreds of KIDs: the resonant frequencies of the superconducting resonators are shifted by mm-wave photons absorption. This tSZ cluster observation demonstrates the potential of the next generation NIKA2 instrument, being developed for the 30m telescope of IRAM, at Pico Veleta (Spain). NIKA2 will have 1000 detectors at 140GHz and 2x2000 detectors at 240GHz, providing in that band also a measurement of the linear polarization. NIKA2 will be commissioned in 2015.