gebhart/patrepeval huggingface dataset:
Supplementary Data from Clinical Benefit of Lapatinib-Based Therapy in Patients with Human Epidermal Growth Factor Receptor 2–Positive Breast Tumors Coexpressing the Truncated p95HER2 Receptor (2023)

Supplementary Data from Clinical Benefit of Lapatinib-Based Therapy in Patients with Human Epidermal Growth Factor Receptor 2–Positive Breast Tumors Coexpressing the Truncated p95HER2 Receptor
Molecular genetics of the cAMP-dependent protein kinase pathway and of sporadic pituitary tumorigenesis (2007)

Pituitary tumors are among the most common human neoplasms. Although these common lesions rarely become clinically manifest and they are almost never malignant, they are the cause of significant morbidity in affected patients. The genetic causes of common pituitary tumors remain for the most part unknown; progress has been limited to the elucidation of the molecular etiology of four genetic syndromes predisposing to pituitary neoplasias: McCune-Albright syndrome, multiple endocrine neoplasia type 1, Carney complex and, most recently, familial acromegaly and prolactinomas and other tumors caused by mutations in the GNAS, menin, PRKAR1A, AIP, and p27 (CDKN1B) genes, respectively. Intense molecular studies of sporadic pituitary tumors from patients with negative family histories and no other neoplasms have yielded interesting findings with abnormalities in growth factor expression and cell cycle control dysregulation. To add to the difficulties in understanding pituitary tumorigenesis in man, good murine models of these neoplasms simply do not exist: pituitary tumors are common in rodents, but their histologic origin (mostly from the intermediate lobe), age of presentation (late in murine life) and clinical course make them hardly models of their human counterparts. The present report reviews the clinical and molecular genetics of the cAMP-dependent protein kinase pathway in human pituitary tumors; it also reviews briefly other pathways that have been involved in sporadic pituitary neoplasms. At the end, we attempt a unifying hypothesis for pituitary tumorigenesis, taking into account data that are also discussed elsewhere in this issue.
Analysis of Rates of Multiple Enzymes in Cell Lysates by Electrospray Ionization Mass Spectrometry J. Am. Chem. Soc. 1999, 121, 1102−1103 (1999)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionAnalysis of Rates of Multiple Enzymes in Cell Lysates by Electrospray Ionization Mass Spectrometry J. Am. Chem. Soc.1999, 121, 1102−1103Scott A. Gerber, C. Ronald Scott, Frantisek Turecek, and Michael H. GelbCite this: J. Am. Chem. Soc. 1999, 121, 8, 1762Publication Date (Web):March 3, 1999Publication History Published online3 March 1999Published inissue 1 March 1999https://pubs.acs.org/doi/10.1021/ja995502vhttps://doi.org/10.1021/ja995502vcorrectionACS PublicationsCopyright © 1999 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views315Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (9 KB) Get e-Alertsclose Get e-Alerts
Rapidities of produced particles in 200-GeV/cπ+/p/K+interactions on Au, Ag, and Mg (1990)

We have used the Fermilab 30-in. bubble chamber--hybrid spectrometer to study the rapidities of ``produced particles'' in the interactions of 200-GeV/c protons and ${\ensuremath{\pi}}^{+}$ and ${K}^{+}$ mesons with nuclei of gold, silver, and magnesium. The average rapidity decreases linearly with the number of projectile collisions ${\ensuremath{\nu}}_{p}$ (up to ${\ensuremath{\nu}}_{p}$=5) with no A dependence and little beam dependence. The ratio R of normalized rapidity distributions for hadron-nucleus to hadron-proton interactions shows a plateau in the central region, and becomes much larger in the target region. However, the increase is significantly less than has been reported in previous experiments. As a function of ${\ensuremath{\nu}}_{p}$, the ratio R rises linearly in the target region, more gently in the central region, and decreases slowly in the projectile region, in all cases with no A dependence. Some discrepancies with a previous experiment are observed in the central region. Long-range rapidity correlations are observed in hadron-nucleus events, but not in hadron-proton events. For the former, it is shown that the correlations exist only for those events with multiple projectile collisions, as expected in the multichain dual parton model.
Preliminary study of suprathermal alpha particle heating (1975)

Some of the consequences of the suprathermal orbits on particle confinement and heating are examined. The guiding-center approximation along with the conservation equations of energy, magnetic moment, and canonical angular momentum were used in the analysis. An example calculation is presented. (MOW)
AN OBSERVATION METHOD OF MOVING OBJECTS ON FREQUENCY DOMAIN (2003)

Abstract- The indirect measurement methods like as image processing measurement are preferably used on the factory automation system because the complex data processing are requested on higher level measurement. On this case, the video system is regarded as the transducer, signal transmitter, signal conditioner and interface unit for a computer, and this system requires low costs by the mass production effect and has easiness of handling. On higher-level measurement, electric quantity must be changed to appropriate projective space though the electric quantity is directly used in the usual measurement such as time domain. The Fourier transformation is an example of the higher-level measurement; and is to change time domain to frequency domain. One of the frequency domain methods to measure object movement using image processing method is shown in this report.
Construction of a Consensus Genetic Map from Two Interspecific Crosses (2002)

A consensus map of homologous DNA linkage groups from two genotypes in each of two Saccharum species was aligned with the compact diploid genome of Sorghum bicolor (L.) Moench. A set of 439 DNA probes from different Poaceae (grasses) detected 2523 loci in two segregating populations derived from the crosses Saccharum officinarum L.'Green German' × S. spontaneum L. ‘IND 81-146’, and S. spontaneum ‘PIN 84-1’ × S. officinarum ‘Muntok Java’. Genetic maps of the four Saccharum genotypes, including a total of 289 linkage groups (LGs), were assembled into 13 homologous groups (HGs) on the basis of parallel arrangements of duplicated loci. The consensus map of HGs consisted of 232 probes and 982 mapped loci/alleles in four sugarcane linkage maps. Of the 982 loci/alleles on the consensus map, 845 (86%) of them correspond to a single linkage group of Sorghum, indicating the highly conserved genome structure between these two closely related genera. At least six basic chromosomes, LGs A, D, F, H, I, and J, showed close correspondence to each other in Saccharum and Sorghum Two possible chromosome fusion events were found in S. spontaneum corresponding to sorghum LG B fused with LG E, and LG B fused with LG G. This consensus map illustrates how the high-density sorghum linkage map can be used to facilitate the mapping and understanding of the complex sugarcane genome.
Robustness of spatial averaging equalization methods: a statistical approach (2003)

Traditionally, room response equalization is performed to improve sound quality at a given listener. However, room responses vary with source and listener positions. Hence, in a multiple listener environment, equalization may be performed through spatial averaging of room responses. However, the performance of averaging based equalization, at the listeners may be affected when listener position changes. In this paper, we present a statistical approach to map variations in listener positions to performance of spatial averaging based equalization. The results indicate that, for the analyzed listener configurations, the zone of equalization depends on distance of microphones from a source and the frequencies in the sound.
Functional Evaluation of a Bioartificial Liver Support System Using Immobilized Hepatocyte Spheroids in a Porcine Model of Acute Liver Failure (2017)

Bioartificial livers (BAL) may offer acute liver failure (ALF) patients an opportunity for cure without liver transplantation. We evaluated the efficacy of a spheroid-based BAL system, containing aggregates of porcine hepatocytes, in a porcine model of ALF. ALF pigs were divided into three groups. The control group consisted of treatment naïve pigs (n = 5), blank group consisted of pigs that were attached to the BAL system not containing hepatocytes for 12 hours (n = 5) and BAL group consisted of pigs that were attached to the BAL containing hepatocytes for 12 hours (n = 5). Increase in serum ammonia levels were significantly greater in the blank group (P < 0.01) and control group (P < 0.01), compared to the BAL group during the treatment period. Increase in ICP was significantly greater in the control group compared to the BAL group (P = 0.01). Survival was significantly prolonged in the BAL group compared to the blank group (P = 0.03). A BAL system with a bioreactor containing hepatocyte spheroids showed effective clearance of serum ammonia, preservation of renal function and delayed ICP increase in a porcine model of ALF.
Evolution of urban robotic system developments (1999)

Urban settings represent a challenging environment for teleoperated and autonomous robot systems. We present several different improved and novel robotic locomotion and exploration/inspection systems designed for the arenas of military reconnaissance and even entertainment/toys. The designs presented in this paper focus in on all- and flat-floor teleoperated/autonomous-capability robotic platforms developed at CMU over the past year. The Pandora and Minidora robot systems are tracked robot systems with self-contained computing, power and wireless communications systems. A sensor suite including stereoscopic and panospheric cameras, light-stripers and acoustic sonar-ring(s) allow the systems to operate autonomously. Individually adjustable track-modules give both of these robot systems extreme mobility in natural (vegetation, soils) and man-made (roads, steps) outdoor environments as well as indoor arenas (sewers, staircases, etc.). The Cyclops and Omniclops robot systems are self-driving spherical camera-platforms intended to be deployed on indoor flat-floor terrain for exploration tasks. Both systems also are fully self-contained in terms of locomotion, computing, power, and control. Both systems differ in their design for rolling and steering, as well as the camera sensor used-all these will be detailed in this paper. Locomotion for all the above systems was shown successfully over various flat and extreme terrains, including reconfiguration to best suit the terrain and enable future sensor-supported autonomous operations.
Effect of Environment on Resistance to the European Corn Borer (Lepidoptera: Crambidae) in Maize (2004)

The European corn borer, Ostrinia nubilalis (Hübner) (Lepidoptera: Crambidae), is a major pest of maize, Zea mays L., in many temperate parts of the world. Genotype-by-environment interaction effects can make relative performance unpredictable and may hamper selection for resistance to European corn borer. The objective of this study was to determine the effect of environment on genotypic reaction to European corn borer resistance in maize. A set of 12 maize inbred lines was chosen to represent a range of European corn borer responses. Eleven testing environments ranged from Delaware, Ohio, Illinois, Iowa, Nebraska, Missouri, to Mississippi. For length of stalk tunneling, environmental and genotypic main effects (estimated by restricted maximum likelihood) were >20- and 10-fold larger than their interaction effect, respectively. Length of tunneling means for genotypes (across environments) ranged from 10.1 to 35.4 cm. Several putatively resistant genotypes grouped with the susceptible checks, B73 and Mol7. By breaking factors and the interaction into single degree of freedom components, we observed that GEMS-0001 had significant crossover interactions toward less susceptibility in both Mississippi and the Nebraska environments. Environments displaying several crossover interactions indicated that European corn borer screening at these sites would not necessarily apply to other locations, whether due to small differences in experimental conduct and/or environmental effects. The five most resistant genotypes were fairly consistent across environments. Because all environments except Illinois used larvae from the same insectary, and these environments differed in damage intensity and rankings, it is unlikely that insect biotype was a factor contributing to genotype-by-environment effects.
Risk for the release of an enormous amount of nanoplastics and microplastics from partially biodegradable polymer blends (2022)

Non-biodegradable polymers are released as microplastics into the environments during the biodegradation of partially biodegradable polymer blends.
INTRAMUSCULAR PO2 DETERMINED BY NEAR INFRARED SPECTROSCOPY IS AN EARLY INDICATOR OF HEMODYNAMIC INSTABILITY IN A LOWER BODY NEGATIVE PRESSURE MODEL OF HEMORRHAGIC SHOCK (2006)

Background: Routine clinical parameters such as hypotension and tachycardia are suboptimal indicators of of blood volume loss during hemorrhage. A noninvasive monitor to help identify hemodynamic instability prior to its onset would allow rapid treatment of trauma patients to prevent oxygen debt, multisystem dysfunction and cardiovascular collapse. Near infrared spectroscopic (NIRS) measurement of muscle oxygenation (PO2) is noninvasive, continuous and can be applied quickly on a trauma patient. Lower body negative pressure (LBNP) has been used to create progressive central hypovolemia in healthy human volunteers (1). We hypothesized that noninvasively measured PO2 would provide an earlier indication of imminent hemodynamic instability during progressive hypovolemia compared to standard vital signs. Methods: 10 healthy human volunteers underwent LBNP in 5 min intervals of −15, −30, −45, and −60 mm Hg, then increasing by −10 mm Hg to presyncope. Mean arterial pressure, heart rate, cardiac output, stroke volume and pulse pressure were measured continuously and noninvasively throughout the study. Intramuscular (IM) PO2 was measured noninvasively with a NIRS sensor placed on the forearm. IM PO2 was determined from muscle oxygen saturation calculated with a novel application of Beer's Law (2). Average values for NIRS IM PO2 and each hemodynamic parameter were obtained and the percent change from baseline was calculated. Paired t-tests, corrected for multiple comparisons, were used to identify the lowest LBNP level where the tested parameter was statistically different from baseline. Results: NIRS IM PO2, stroke volume and pulse pressure decreased linearly with increasing negative pressure (R2 = 0.98) and were the earliest indicators of impending cardiovascular collapse (Table I). Change in blood pressure only reached statistical significance at −80 mm Hg.TableDiscussion/Conclusion: NIRS IM PO2 has the sensitivity to detect a decrease in muscle perfusion. The NIRS PO2 sensor shows promise for detecting very early changes in IM PO2 during the progression toward hemorrhagic shock, obviating the need for more invasive monitors. This sensor can be easily used both in pre-clinical and in-hospital situations. This work was funded by the US Army Medical Research and Materiel Command.
Preexisting memory CD4+ T cells contribute to the primary response in an HIV-1 vaccine trial (2021)

Naive and memory CD4+ T cells reactive with human immunodeficiency virus type 1 (HIV-1) are detectable in unexposed, unimmunized individuals. The contribution of preexisting CD4+ T cells to a primary immune response was investigated in 20 HIV-1–seronegative volunteers vaccinated with an HIV-1 envelope (Env) plasmid DNA prime and recombinant modified vaccinia virus Ankara (MVA) boost in the HVTN 106 vaccine trial (clinicaltrials.gov NCT02296541). Prevaccination naive or memory CD4+ T cell responses directed against peptide epitopes in Env were identified in 14 individuals. After priming with DNA, 40% (8/20) of the elicited responses matched epitopes detected in the corresponding preimmunization memory repertoires, and clonotypes were shared before and after vaccination in 2 representative volunteers. In contrast, there were no shared epitope specificities between the preimmunization memory compartment and responses detected after boosting with recombinant MVA expressing a heterologous Env. Preexisting memory CD4+ T cells therefore shape the early immune response to vaccination with a previously unencountered HIV-1 antigen.
Photoresponsive Liquid Crystalline Polymeric Materials (2012)

In-situ photopolymerization of liquid crystalline (LC) monomers has proven to be a valuable technique for the formation of well-ordered polymer networks. Their anisotropic properties led to a variety of applications in optics, electronics and mechanics. The use of light to initiate polymerization enables lithographic patterning. In addition the LC behavior enables formation of complex morphologies on molecular level. Controlling the director profile of an LC network film in transversal direction gives geometrical morphing upon minor changes in order parameter. Examples of suited profiles of molecular orientation are twisted or splayed director configurations tied up in the network configuration. Reversible order parameter changes can be induced by light using the photo-activated trans-cis isomerization of a copolymerized azobenzene monomer. This is demonstrated in photoresponsive cilia inkjet printed on a substrate. The cilia possess a splayed molecular organization and show well-controlled bending when addressed by light. We demonstrate a patterned film with alternating helicoidal and perpendicular-uniaxial molecular orientation. When applied as coating on glass, photo-activation in this case leads to a dynamically switching surface topology
Pd Seed Layer for Electroless Cu Deposition on TaN Diffusion Barrier by Self-Assembled-Monolayer Method (SAM) (2007)

Electroless deposition(ELD) was applied to fabricate Cu interconnections on a TaN diffusion barrier with Pd seed layer. The Pd seed layer was obtained by self-assembled monolayer method(SAM) with PDDA and PSS as surfactants. We were able to obtain about 10nm Pd nano particles as seeds for electroless Cu deposition and the density of Pd seeds was much higher than that of Pd seeds fabricated by conventional Pd sensitization-activation method. Also we were able to obtain finer Cu interconnections by ELD. Therefore we concluded that the Pd seed layer by SAM was able to be applied to form Cu interconnection by ELD for under 30nm feature.
Comparison of SiC Epitaxial Growth from Dichlorosilane and Tetrafluorosilane Precursors (2013)

As a novel Si-precursor in chemical vapor deposition epitaxial growth of 4H-SiC, tetrafluorosilane (TFS) is studied for both its advantages and disadvantages. Due to its high Si-F binding energy, TFS presents exceptional ability in the suppression of parasitic deposition and Si-droplet formation during SiC epitaxial growth. As compared with epigrowth using a chlorinated precursor, dichlorosilane (DCS), growth using TFS shows a lower growth rate most likely due to the TFS etching of SiC during growth and the lower reactivity of TFS, but the quality of the TFS grown epilayers is always superior. Epigrowth using TFS also shows better control of the uniformities of epilayer surface morphology and doping concentration, which offers excellent uniformity of SiC device performance. The influence of growth conditions including temperature, gas flow rate, Si/H 2 ratio, and C/Si ratio on growth rate and epilayer properties is investigated in growth using TFS and compared with growth using DCS.
Microstructure and Property Control of CoNiCrAlY Based Abradable Coatings for Optimal Performance (2000)

Abstract A CoNiCrAlY-hBN/Polyester material has recently been developed for clearance control applications in gas turbine compressors that use titanium alloy blades. While engine tests serve as the final evaluation of the coating performance, quality assurance laboratories and production shops would rely upon the more readily available coating hardness values to predict performance. This paper will focus on the reproducibility of coating macrohardness with a plasma spray process. It is shown that plasma spray parameters affect the hardness of CoNiCrAlY-hBN/Polyester coatings by changing the level of polyesters retained in the coating and the volume percentage of metallic matrix. The correlation between hardness, retained polyester level and microstructure of these coatings is captured in a coating hardness map from which desired microstructure and polyester entrapment are determined. Based on the understanding of the correlation between coating hardness and microstructural features, the use of additional criteria other than hardness such as retained polyester level and non-metallic portion of the coating is recommended in order to assure the quality of the coating more effectively.
Reply to the Discussion (2010)

Abstract H. Zeng proposes that a field be defined as “a physical or geophysical effect existing in a space” instead of the Encyclopedic Dictionary's current wording, “the space in which an effect…is measurable.”
Active silicon-based shockwave formation (2008)

An active shockwave transmission line topology is presented that demonstrates edge sharpening to under 10ps using an impedance variation technique. The circuit is demonstrate to sharpen the transition time for periodic signals and consumes under 20mW while reducing the fall time by 20ps. The circuit is fabricated in a 120nm CMOS technology and occupies an area of 1.5mm by 0.4mm.