gebhart/patrepeval huggingface dataset:
Line spread function (LSF) study of a multimedia detector for X-ray digital imaging (2003)

An experimental study is in process aimed at enhancing the signal line spread function (LSF) of a novel imaging sensor which utilizes gas and semiconductor detector volumes. Preliminary results indicate the presence of general space charge nonlinearities which are partially reduced by adding a small amount of methane. A significant improvement of the signal LSF is expected by adding traces of polar molecules with low ionization potential. The final goal of this study is to develop a high resolution imaging sensor for dual-energy medical imaging.
Susceptibility studies of laccase and oxyhemocyanin using an ultrasensitive magnetometer. Antiferromagnetic behavior of the type 3 copper in Rhus laccase (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSusceptibility studies of laccase and oxyhemocyanin using an ultrasensitive magnetometer. Antiferromagnetic behavior of the type 3 copper in Rhus laccaseEdward I. Solomon, David M. Dooley, Run-Han Wang, Harry B. Gray, M. Cerdonio, F. Mogno, and G. L. RomaniCite this: J. Am. Chem. Soc. 1976, 98, 4, 1029–1031Publication Date (Print):February 1, 1976Publication History Published online1 May 2002Published inissue 1 February 1976https://pubs.acs.org/doi/10.1021/ja00420a035https://doi.org/10.1021/ja00420a035research-articleACS PublicationsRequest reuse permissionsArticle Views193Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non–small cell lung cancer (2022)

In the treatment of non-small cell lung cancer (NSCLC), patients harboring exon 20 insertion mutations in the epidermal growth factor receptor (EGFR) gene (EGFR) have few effective therapies because this subset of mutants is generally resistant to most currently approved EGFR inhibitors. This report describes the structure-guided design of a novel series of potent, irreversible inhibitors of EGFR exon 20 insertion mutations, including the V769_D770insASV and D770_N771insSVD mutants. Extensive structure-activity relationship (SAR) studies led to the discovery of mobocertinib (compound 21c), which inhibited growth of Ba/F3 cells expressing the ASV insertion with a half-maximal inhibitory concentration of 11 nM and with selectivity over wild-type EGFR. Daily oral administration of mobocertinib induced tumor regression in a Ba/F3 ASV xenograft mouse model at well-tolerated doses. Mobocertinib was approved in September 2021 for the treatment of adult patients with advanced NSCLC with EGFR exon 20 insertion mutations with progression on or after platinum-based chemotherapy.
Corrosion and materials selection issues in carbon capture plants (2011)

The construction of the process plant required for carbon capture in power generation and also other industrial processes is expected to be among the most significant capital investments of the next 20–30 years. The correct choice of materials for piping, vessels and all types of equipment will be vital in ensuring the long-term performance, safety and high operational availability of the capture plants through their lifetime. Controlling capital and operating costs related to materials will help enable a wider and faster roll-out of carbon capture systems. It is apparent that there is a need to investigate the potential materials degradation and corrosion risks in the carbon capture processes and the related material selection issues. The International Energy Agency Greenhouse Gas (IEA GHG) Research and Development Programme has sponsored a study of corrosion issues and materials selection in carbon capture, transport and storage. This paper summarises some of the outcomes of that study relating to the carbon capture systems. The focus is on materials degradation risks from the process streams and materials issues specific to the carbon capture processes. An overview is provided of corrosion and materials issues related to the three main carbon capture processes (Post-combustion, Pre-combustion (IGCC) and Oxy-fuel). Some specific corrosion issues and problems are discussed. Areas where potential problems exist or where further studies are required are highlighted.
Numerical Study of a Micro Gas Turbine Fed by Liquid Fuels: Potentialities and Critical Issues (2015)

Aim of the paper is to evaluate the potentialities and critical issues of the micro-gas turbine Turbec T100 properly modified in order to be powered by liquid fuels. The main difference with respect to the version designed for gaseous fuels concerns the combustor, namely the combustion chamber and the fuel injection system. The numerical study was carried out using both a 0D matching analysis and a 3D CFD analysis of the combustor. The thermodynamic model, coupled with the operating maps of rotating components, was calibrated using the experimental data collected during operation of the micro-gas turbine with gaseous fuel. The operative parameters computed through the 0D model have been utilized to simulate the behavior of micro-gas turbine fed by liquid fuels, thus obtaining the initial and boundary conditions to be used in the CFD analysis. The combustion process of liquid fuels is analyzed; the main differences at varying loads are discussed in terms of temperature and velocity profiles of the air flows inside the combustion chamber and mean values of turbine inlet temperature and exhaust gaseous concentration. A preliminary study concerning the characteristics of the injection system is also reported.
Efficient Load-Aware Channel Allocation in Wireless Access Networks (2011)

Dense deployments of hybrid WLANs result in high levels of interference and low end-user throughput. Many frequency allocation mechanisms for WLANs have been proposed by a large body of previous studies. However, none of these mechanisms considers the load that is carried by APs in terms of channel conditions, number of affiliated users as well as communication-load, in conjunction. In this paper, we propose LAC, a load-aware channel allocation scheme for WLANs, which considers all the above performance determinant factors. LAC incorporates an airtime cost metric into its channel scanning process, in order to capture the effects of these factors and select the channel that will provide approximately maximum long-term throughput. We evaluate LAC through extensive OPNET simulations, for many different traffic scenarios. Our simulations demonstrate that LAC outperforms other frequency allocation policies for WLANs in terms of total network throughput by up to 135%.
Twenty-Five Years of Evolution in Speech and Language Processing (2023)

n this article, we summarize the evolution of speech and language processing (SLP) in the past 25 years.We first provide a snapshot of popular research topics and the associated state of the art (SOTA) in various subfields of SLP 25 years ago, and then highlight the shift in research topics over the years.We describe the major breakthroughs in each of the subfields and the main driving forces that led us to the SOTA today.Societal impacts and potential future directions are also discussed.
NIR fluorescent ytterbium compound for in vivo fluorescence molecular imaging (2009)

We have developed a new NIR fluorescent probe based on an ytterbium(III) (E)-1-(pyridin-2-yl-diazenyl)naphthalen-2-ol (PAN) complex. This probe emits near-infrared luminescence derived from the Yb ion through excitation of the PAN moiety with visible light (lambda(ex)= 530 nm, lambda(em)= 975 nm). The results support the possible utility of the probe for in vivo fluorescence molecular imaging.
Tutorial on Components for Next-Generation High-Speed LAN (2005)

Summary form only given. Triggered by the ever-increasing computer speed and the wide application of the Internet, the demand for higher communication bandwidth and interconnectivity is drastically increasing. Networking a group of (computers in proximity to form LAN has become imperative for corporations and organizations to compete and perform.
Novel report of expression and function of CD97 in malignant gliomas: correlation with Wilms tumor 1 expression and glioma cell invasiveness (2012)

Although CD97 expression in gliomas has not been described previously, we conclude that the possible upregulation of CD97 mediated by WT1 promotes cellular invasiveness-one of the most characteristic and challenging aspects of glial tumor cells. Further studies are needed to clarify the nature of this regulation and its impact, as CD97 could represent a novel target for antiglioma therapies.
A balanced sequential design strategy for global surrogate modeling (2013)

The sequential design methodology for global surrogate modeling of complex systems consists of iteratively training the model on a growing set of samples. Sample selection is a critical step in the process and influences the final quality of the model. It is desirable to use as few samples as possible while building an accurate model using insight gained in previous iterations. A robust sampling scheme is considered that employs Monte Carlo Voronoi tessellations for exploration, linear gradients for exploitation and different schemes are investigated to balance their trade-off. The experimental results on benchmark examples indicate that some schemes can result in a substantially smaller model error especially when the system under consideration has a highly non-linear behavior.
Differences in Local and Systemic TFV PK Among Premenopausal Versus Postmenopausal Women Exposed to TFV 1% Vaginal Gel (2018)

The state of the cervicovaginal mucosa has a significant impact on local and systemic PK of a topically applied microbicide.
F-33 Trace Element Detection Using Monochromatic Wavelength Dispersive X-ray Fluorescence (2010)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
In situ hybridization for the detection of telomerase RNA in the progression from barrett's esophagus to esophageal adenocarcinoma (1998)

The results of this study showed that 1) Barrett's epithelium may contain a population of immortalized cells, 2) a marked increase in the level of telomerase RNA accompanies the transition from low grade to high grade dysplasia, and 3) high levels of telomerase RNA accompany the development of esophageal adenocarcinoma in the vast majority of cases.
C232 Fundamental research on the pattern recognition of boiling two-phase flow using pulse ultrasound (2005)

This paper presents the fundamental study of a novel measurement method using ultrasonic echo signals on boiling two-phase flow. The method has the capability of measuring an instantaneous echo intensity profile along an ultrasonic beam, so it is expected to apply on pattern recognition of two-phase flow. The principle of the flow pattern recognition is based on delay time and strength of a pulse echo. In this paper, echo signals reflected on a boundary between water and vapor, were obtained using an ultrasound system, and estimated the effects of boiling phenomena.
Supramolecular Self-Assembling Properties of Membrane-Spanning Archaeal Tetraether Glycolipid Analogues (2002)

The self-assembling properties of a new series of archaeal tetraether glycolipid analogues 1-6 that are characterized by a bipolar architecture with two similar or different glycosidic and/or phosphate polar heads and a lipid core possessing a cyclopentane unit and/or branched chains were studied by means of differential scanning calorimetry, optical microscopy, X-ray scattering, freeze-fracture electron microscopy and dynamic light scattering. Unsymmetrical phosphate derivatives 1 and 2 spontaneously formed thermostable multilamellar and unilamellar vesicles in which most of the bipolar lipids adopted a trans-membrane conformation, as revealed by freeze-fracture electron microscopy. Supramolecular aggregates of neutral glycolipids 3-6 were found to depend on both the saccharidic polar heads and the chain composition. The presence of one glycosidic residue with rather marked hydrophilic properties, such as the lactosyl moiety, was required to allow the formation of multilamellar vesicles. Surprisingly, the introduction of a cyclopentane unit in the bridging chain was able to induce an apparent two-by-two membrane association: this unusual behaviour might be the result of unsymmetrical interfacial properties of the lipid layer caused by the presence of the cyclopentane unit.
M Protein of the Group AStreptococcusBinds to the Seventh Short Consensus Repeat of Human Complement Factor H (1998)

Streptococcus pyogenes evades complement by binding the complement-regulatory protein factor H (fH) via the central conserved C-repeat region of M protein. However, the corresponding binding region within fH has not previously been precisely localized. fH is composed of 20 conserved modules called short consensus repeats (SCRs), each of which contains approximately 60 amino acids. A series of fH truncated and deletion mutants were prepared, and their interaction with M6 protein was examined. The M protein binding site was initially localized to SCRs 6 to 15 as demonstrated by ligand dot blotting, chemical cross-linking, and enzyme-linked immunosorbent assay. SCR 7 was then shown to contain the M protein binding site, as a construct consisting of the first seven SCRs bound M protein but a construct containing the first six SCRs did not bind. In addition, deletion of SCR 7 from full-length fH abolished binding to M protein. SCR 7 is known to contain a heparin binding domain, and binding of fH to M6 protein was almost totally inhibited in the presence of 400 U of heparin per ml. These results localize the M6 protein binding site of fH to SCR 7 and indicate that it is in close proximity to the heparin binding site.
Development of a humanized mouse model for functional testing of biomaterial fibrosis (2019)

Abstract Implanted biomedical devices reside within tens of millions of patients in the United States alone, and are involved in millions of new surgeries every year. They comprise a major component of modern medicine and are essential for many clinical applications ranging from hip/knee replacement, tissue repair/reconstruction, controlled release, sensing, and cell transplantation. Limiting therapeutic performance and lifespan, immune-mediated foreign body rejection results in sequestration behind dense layers of fibrotic scar tissue. Deeper understanding of wildtype rodent and non-human primate foreign body responses was leveraged to generate a variant of humanized mice that is capable of recapitulating fibrosis following implantation. Cellular and cytokine responses were also determined with multiple biomaterials—hydrogel alginate and polymers polystyrene and polydimethylsiloxane (PDMS), as well as across multiple implant sites. Innate immune macrophages were verified as essential in the development of fibrosis in this model, and that they were capable of crosstalk with mouse fibroblasts for collagen matrix deposition. Cytokine and cytokine-receptor array analysis confirmed core signaling in the fibrotic cascade. Lastly, high-resolution microscopy coupled with multiplexed antibody-capture analyses revealed spatial resolution of rejection responses. This model allows us to investigate dynamic human immune cell interactions with implantables, and offers a surrogate pre-clinical diagnostic for screening biomaterial immunogenicity.
Surface Modification of Erythrocytes with Lipid Anchors: Structure–Activity Relationship for Optimal Membrane Incorporation, in vivo Retention, and Immunocompatibility (2022)

Surface Modification In article number 2200037, Dmitri Simberg and co-workers synthesize a library of fluorescent Cy3 lipid derivatives which are incorporated into erythrocyte membranes. The fluorescent label incorporation and retention, erythrocyte circulation and immunocompatibility as a function of lipid structure are studied in vitro and in vivo.
Multiple sclerosis patients have a diminished serologic response to vitamin D supplementation compared to healthy controls (2015)

Patients with MS had a lower increase in 25(OH)D levels with supplementation, even after accounting for putative confounders.
Blockade of the programmed death-1 pathway restores sarcoidosis CD4(+) T-cell proliferative capacity (2014)

Rationale: Effective therapeutic interventions for chronic, idiopathic lung diseases remain elusive. Normalized T-cell function is an important contributor to spontaneous resolution of pulmonary sarcoidosis. Up-regulation of inhibitor receptors, such as programmed death-1 (PD-1) and its ligand, PD-L1, are important inhibitors of T-cell function.Objectives: To determine the effects of PD-1 pathway blockade on sarcoidosis CD4+ T-cell proliferative capacity.Methods: Gene expression profiles of sarcoidosis and healthy control peripheral blood mononuclear cells were analyzed at baseline and follow-up. Flow cytometry was used to measure ex vivo expression of PD-1 and PD-L1 on systemic and bronchoalveolar lavage–derived cells of subjects with sarcoidosis and control subjects, as well as the effects of PD-1 pathway blockade on cellular proliferation after T-cell receptor stimulation. Immunohistochemistry analysis for PD-1/PD-L1 expression was conducted on sarcoidosis, malignant, and healthy control lung specimens...
Using a Data-bearing Frame to Capture an Extended Target (2016)

A system for the automatic detection of the entirety of an arbitrary image target is described. This is achieved by surrounding the target image with a data-bearing halftone or "StegaFrame" and by a camera-based detection system that can efficiently find the StegaFrame by means of judiciously placed detection windows. The frequency-domain-based detection scheme is fast and provides the added advantage of estimating scale and orientation of the desired content. An intuitive user interface guides the user until a successful detection is achieved. This approach is demonstrated in an application to locate and analyze a color chart for the purpose of calibrating a mobile device to be able to measure skin tone. An identifier to access print-run specific colorimetry data, along with other data for client analytics is embedded in the data-bearing border. The design of the detection system is optimized through exhaustive simulation. Experimental results confirm that the automated scheme, implemented on a mobile phone, performs as well as costly dedicated colorimetric hardware.
Effect of Myoarchitectonic Spinolaminoplasty on Concurrent Hypertension in Patients With Cervical Spondylotic Myelopathy (2018)

Hypertension coexisting with CSM can be ameliorated after surgical treatment. The effect is likely to be mediated by moderation of sympathetic activity, rather than parasympathetic activation. We believe that a combination of adequate decompression of the spinal cord and relief from musculoskeletal stresses effectuate this moderation.
Micro-structuring of SiO/sub 2/ thin film on Si by a femto-second laser pulse (2002)

In this paper report that micro-grating structures are holographically encoded in SiO/sub 2/ thin films on Si by colliding a pair of pulses split from a single high peak power fs-laser pulse using a Ti:sapphire laser.
Timing of fungal invasion using host's ripening hormone as a signal. (1994)

In many postharvest fruit diseases, fungi remain latent until the fruit ripens. How the fungus times its infection at ripening of the host is not known. We have found that the volatiles produced by the climacteric tomato, avocado, and banana fruits induce germination and appressorium formation in Colletotrichum gloeosporioides and Colletotrichum musae. Exposure of the spores of these fungi to ethylene, the host's ripening hormone, at </=1 microl/liter, caused germination, branching of the germ tube, and formation of up to six appressoria from a single spore. Propylene, an ethylene analog, but not the hydrocarbon gas methane was able to induce spore germination and multiple appressorium formation. The ethylene effect on the fungi appears to be a plant-like response as it was inhibited by silver ion and 2,5-norbornadiene; the inhibition by the latter could be reversed by higher ethylene concentrations. Ethylene induced germination and appressorium formation in the Colletotrichum sp. penetrating climacteric fruit but not in other Colletotrichum strains. That the ethylene induction of multiple appressorium formation could be relevant to postharvest infection was indicated by the observation that C. gloeosporioides spores formed multiple appressoria on normally ripening tomato that produces ethylene, whereas on transgenic tomato and orange, fruits incapable of producing ethylene, exogenous ethylene was required to induce multiple appressorium formation and lesion formation. These results strongly suggest that these fungi must have coevolved to develop a mechanism to use the host's ripening hormone as a signal to differentiate into multiple infection structure and thus time the infection process.
Bilateral Neuroretinopathy With Multiple Retinal Arterial Aneurysms (2003)

A36-YEAR-OLDwoman soughttreatmentfor sudden onset of an inferonasal scotoma in the right eye.Herconditionwasdiagnosedas bilateral neuroretinitis with branch retinal vein occlusion and treated with oral prednisone (60 mg once daily) and ciprofloxacin (500 mg twice daily); however, she saw no improvement during the next 4 months. Findings from a systemic evaluation, including erythrocyte sedimentationrate,rapidplasmareagin level, lysozyme level, purified protein derivative level, Bartonella henselae titer, anticardiolipin antibodylevel,lupusanticoagulantlevel, and a chest radiograph, were nor
A Novel Subspace Based Method for Compensation of Multiple CFOs in Uplink MIMO OFDM Systems (2017)

The tri-linear data model for an arbitrary multi-user uplink multiple input multiple output (MIMO) orthogonal frequency division multiplexing (OFDM) system comprising orthogonal frequency division multiplexing access users and co-channel (CC) users is formulated in this letter. A novel subspace-based method for multi-access interference cancellation and CC data separation in multi-user MIMO OFDM systems, utilizing the independent manifolds spanned by user's carrier frequency offset matrix, is proposed in this letter. The system constraints under which the proposed subspace nulling method works are derived, which includes the under-determined cases, where minimum mean square error/zero forcing methods fail.