gebhart/patrepeval huggingface dataset:
Urinary Bisphenol A Concentration and Angiography-Defined Coronary Artery Stenosis (2012)

BPA exposure was higher in those with severe coronary artery stenoses compared to those with no vessel disease. Larger studies are needed to estimate true dose response relationships. The mechanisms underlying the association remain to be established.
Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis (2023)

In pancreatic ductal adenocarcinoma (PDAC) patients, we show that response to radiation therapy (RT) is characterized by increased IL-2Rβ and IL-2Rγ along with decreased IL-2Rα expression. The bispecific PD1-IL2v is a PD-1-targeted IL-2 variant (IL-2v) immunocytokine with engineered IL-2 cis targeted to PD-1 and abolished IL-2Rα binding, which enhances tumor-antigen-specific T cell activation while reducing regulatory T cell (Treg) suppression. Using PD1-IL2v in orthotopic PDAC KPC-driven tumor models, we show marked improvement in local and metastatic survival, along with a profound increase in tumor-infiltrating CD8<sup>+</sup> T cell subsets with a transcriptionally and metabolically active phenotype and preferential activation of antigen-specific CD8<sup>+</sup> T cells. In combination with single-dose RT, PD1-IL2v treatment results in a robust, durable expansion of polyfunctional CD8<sup>+</sup> T cells, T cell stemness, tumor-specific memory immune response, natural killer (NK) cell activation, and decreased Tregs. These data show that PD1-IL2v leads to profound local and distant response in PDAC.
59‐6: Directed Electrostatic Microassembly for MicroLED Display (2021)

We are developing a new chip integration tool based on massively parallel deterministic sorting and assembly, aiming to achieve the low cost of printing with the control of pick and place. Such a tool would enable scalable microLED display manufacturing and heterogeneous integration for advanced functionality. We describe a prototype system demonstrating continuous line by line assembly, and report single chip speed measurements of a centimeter per second, suggesting the approach could eventually support high throughput.
Barley transcript profiles under dehydration shock and drought stress treatments: a comparative analysis (2006)

A microarray including 1654 cDNAs, mainly derived from dehydration-shocked barley leaf tissues, was utilized to monitor expression changes in leaves of barley plants subjected to slow drying conditions (7 d and 11 d: 7d-WS and 11d-WS) in soil and after rehydration. The results were compared with those obtained under shock-like conditions imposed with a 6 h dehydration treatment. A total number of 173 transcripts (approximately 10% of all transcripts profiled) were declared up- or down-regulated in at least one of the conditions tested. The majority of the transcripts were regulated by only one of the drought treatments, with 57% of the differentially expressed transcripts exclusively affected in the dehydration shock treatment, 6% at 7d-WS, 14% at 11d-WS, and 6% after rehydration. Irrespective of the low percentage of transcripts (10%) with similar expression changes between shock and slow stress treatments, a sizeable portion of these transcripts shared a common expression trend under the different drought treatment conditions, as evidenced by low but significant correlations between the fast occurring and the 7d-WS and 11d-WS treatments (r=0.32 and 0.41, P=0.001, respectively). These results are discussed with respect to the merit of different dehydration treatments in the investigation of the changes in transcript profiling.
A Year for Nanoscience (2014)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTA Year for NanoscienceWarren C. W. Chan, Yury Gogotsi, Jason H. Hafner, Paula T. Hammond, Mark C. Hersam, Ali Javey, Cherie R. Kagan, Ali Khademhosseini, Nicholas A. Kotov, Shuit-Tong Lee, Helmuth Möhwald, Paul A. Mulvaney, Andre E. Nel, Peter J. Nordlander, Wolfgang J. Parak, Reginald M. Penner, Andrey L. Rogach, Raymond E. Schaak, Molly M. Stevens, Andrew T. S. Wee, C. Grant Willson, and Paul S. WeissCite this: ACS Nano 2014, 8, 12, 11901–11903Publication Date (Web):December 23, 2014Publication History Published online23 December 2014Published inissue 23 December 2014https://pubs.acs.org/doi/10.1021/nn5070716https://doi.org/10.1021/nn5070716editorialACS PublicationsCopyright © 2014 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views3212Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (845 KB) Get e-AlertscloseSUBJECTS:Nanoscale,Nanoscience,Nanotechnology Get e-Alerts
A neutral network for isolated-word recognition (2003)

Algorithms that are implementable by artificial neural networks show promise of augmenting the field of automatic speech recognition. A specific approach to the problem of isolated-word recognition was initiated by Tank and Hopfield. These ideas were applied to a concatenated systems consisting of a vector quantizer, a time concentrator with vector sequences as input and allophones as output and a final stage with allophone sequence as input and isolated words as output. Improvements in the system are discussed; included are the addition of data-dependent 'phenomenological' rules that yield improved results for a single-speaker 35-word vocabulary isolated-word recognition task.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Locating Family Values: A Field Trial of the Whereabouts Clock (Nominated for the Best Paper Award) (2007)

We report the results of a long-term, multi-site field trial of a situated awareness device for families called the Whereabouts Clock. The Clock displayed family members' current location as one of four privacy-preserving, deliberately coarse-grained categories (HOME, WORK, SCHOOL or ELSEWHERE). In use, the Clock supported not only family co-ordination but also more emotive aspects of family life such as reassurance, connectedness, identity and social touch. This emphasized aspects of family life frequently neglected in Ubicomp, such as the ways in which families' awareness of each others' activities contributes to a sense of a family's identity. We draw further on the results to differentiate between location as a technical aspect of awareness systems and what we characterize as location-in-interaction. Location-in-interaction is revealed as an emotional, accountable and even moral part of family life.
Multi-task learning for spoken language understanding with shared slots (2011)

This paper addresses the problem of learning multiple spoken language understanding (SLU) tasks that have overlapping sets of slots. In such a scenario, it is possible to achieve better slot filling performance by learning multiple tasks simultaneously, as opposed to learning them independently. We focus on presenting a number of simple multi-task learning algorithms for slot filling systems based on semi-Markov CRFs, assuming the knowledge of shared slots. Furthermore, we discuss an intradomain clustering method that automatically discovers shared slots from training data. The effectiveness of our proposed approaches is demonstrated in an SLU application that involves three different yet related tasks.
Inside Cover: Direct Light‐Driven Modulation of Luminescence from Mn‐Doped ZnSe Quantum Dots (Angew. Chem. Int. Ed. 14/2008) (2008)

Light-driven control of the fluorescence from Mn-doped ZnSe quantum dots is described by S. Hell and co-workers in their Communication on page 2685 ff. Blue light is used to excite the quantum nanocrystals, while a second longer wavelength modulated beam (red) can be used to selectively gate the fluorescence from the quantum dots. The lower right inset illustrates the energy levels involved in the light-controlled fluorescence from Mn-doped quantum dots.
Performance of External Quality Control Systems (1989)

Journal Article Performance of External Quality Control Systems Get access Sharon S. Ehrmeyer, PhD, Sharon S. Ehrmeyer, PhD School of Allied Health Professions (Dr Ehrmeyer) and the Departments of Preventive Medicine and Pathology and Laboratory Medicine (Dr Laessig), University of Wisconsin, Madison, WI53706, and Park Nicollet Medical Center, Minneapolis, MN 55416 (Dr Cembrowski). Search for other works by this author on: Oxford Academic PubMed Google Scholar Ronald H. Laessig, PhD, Ronald H. Laessig, PhD School of Allied Health Professions (Dr Ehrmeyer) and the Departments of Preventive Medicine and Pathology and Laboratory Medicine (Dr Laessig), University of Wisconsin, Madison, WI53706, and Park Nicollet Medical Center, Minneapolis, MN 55416 (Dr Cembrowski). Search for other works by this author on: Oxford Academic PubMed Google Scholar George S. Cembrowski, MD, PhD George S. Cembrowski, MD, PhD School of Allied Health Professions (Dr Ehrmeyer) and the Departments of Preventive Medicine and Pathology and Laboratory Medicine (Dr Laessig), University of Wisconsin, Madison, WI53706, and Park Nicollet Medical Center, Minneapolis, MN 55416 (Dr Cembrowski). Search for other works by this author on: Oxford Academic PubMed Google Scholar Laboratory Medicine, Volume 20, Issue 6, 1 June 1989, Pages 428–431, https://doi.org/10.1093/labmed/20.6.428 Published: 01 June 1989
Ketenyl radical yield of the elementary reaction of ethyne with atomic oxygen at 290-540 K (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKetenyl radical yield of the elementary reaction of ethyne with atomic oxygen at 290-540 KJ. Peeters, M. Schaekers, and C. VinckierCite this: J. Phys. Chem. 1986, 90, 24, 6552–6557Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://pubs.acs.org/doi/10.1021/j100282a027https://doi.org/10.1021/j100282a027research-articleACS PublicationsRequest reuse permissionsArticle Views105Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Prior expectations in slant perception: Has the visual system internalized natural scene geometry? (2010)

In perceptual experiments, the perceived slant is frequently less than the physically specified slant. We show that this slant underestimation can be successfully predicted by a probabilistic model that combines current measurements with a prior expectation of zero slant. From the geometry of natural scenes, one can make a prediction about the shape and spread of the prior. The probability that a line of sight will intersect a surface rotated by a random amount about a vertical axis is a half-cosine distribution centered at 0deg. We asked whether the visual system behaves as if it has internalized this predicted distribution of likely slants. The probabilistic model predicts different effects of the prior depending on the reliability and slant of the surface. Estimating the visual system's internal prior from measured psychophysical data is challenging because observer responses are affected by both the prior and the unknown likelihood. To measure the visual system's prior, we presented two slanted planes and observers indicated which was more slanted. The stimuli were either regular grid-like textures for which slant was reliably discriminated (R) or irregular textures for which slant was unreliably discriminated (U). A range of base slants was presented in three types of trials: UvsU, RvsR, and UvsR. To eliminate any cues that could bias the visual system towards slant estimates of zero, we used real surfaces. We found that observers systematically underestimated the slant of the unreliable stimulus relative to the reliable stimulus in a manner consistent with the probabilistic model. From the psychophysical data we inferred the spread and shape of the internal prior distribution using a technique similar to Stocker and Simoncelli (2006). The priors reconstructed from the data were peaked at zero slant and were similar to the theoretical expectation.
Human Bleomycin Hydrolase:  Molecular Cloning, Sequencing, Functional Expression, and Enzymatic Characterization (1996)

We have cloned the cDNA of human bleomycin hydrolase (hBH), a protease which is thought to be involved in the metabolic inactivation of the antineoplastic drug bleomycin. The open reading frame consists of 1365 base pairs and is predicted to encode a 52 kDa protein. The protein shares 40% identity with yeast bleomycin hydrolase and contains the conserved active site residues (Cys, His, Asn) characteristic for cysteine proteases of the papain superfamily. Human bleomycin hydrolase has been functionally expressed in Spodoptera frugiperda Sf9 cells using the Autographa californica nuclear polyhedrosis virus. The 52 kDa recombinant protein forms a hexamer of 310 kDa and acts strictly as an aminopeptidase with a broad substrate specificity. The lack of a leader sequence and its pH optimum at 7.2 suggest a cytosolic/nuclear localization. Human bleomycin hydrolase was detected at low to moderate expression levels in most of the human organs tested. Significantly higher RNA levels have been observed in a variety of tumor cell lines. The human enzyme effectively degrades both forms of bleomycin (A2 and B2) in vitro and could indeed be responsible for the resistance of various tumors to this widely used anticancer drug.
Improving CDR Performance via Estimation (2006)

A dual-loop CDR can be viewed as a simple phase-estimator. Different estimators can be built by changing the phase DAC control logic. Three different 0.13μm estimators for a 3Gb/s serial link are presented. These estimators address dual-loop CDR limitations including lock time, frequency range, and jitter tolerance in non-mesochronous systems
Bright and photostable chemigenetic indicators for extended in vivo voltage imaging (2018)

Abstract Imaging changes in membrane potential using genetically encoded fluorescent voltage indicators (GEVIs) has great potential for monitoring neuronal activity with high spatial and temporal resolution. Brightness and photostability of fluorescent proteins and rhodopsins have limited the utility of existing GEVIs. We engineered a novel GEVI, ‘Voltron’, that utilizes bright and photostable synthetic dyes instead of protein-based fluorophores, extending the combined duration of imaging and number of neurons imaged simultaneously by more than tenfold relative to existing GEVIs. We used Voltron for in vivo voltage imaging in mice, zebrafish, and fruit flies. In mouse cortex, Voltron allowed single-trial recording of spikes and subthreshold voltage signals from dozens of neurons simultaneously, over 15 minutes of continuous imaging. In larval zebrafish, Voltron enabled the precise correlation of spike timing with behavior.
IDH1 mutation detection by droplet digital PCR in glioma (2015)

Glioma is the most frequent central nervous system tumor in adults. The overall survival of glioma patients is disappointing, mostly due to the poor prognosis of glioblastoma (Grade IV glioma). Isocitrate dehydrogenase (IDH) is a key factor in metabolism and catalyzes the oxidative decarboxylation of isocitrate. Mutations in IDH genes are observed in over 70% of low-grade gliomas and some cases of glioblastoma. As the most frequent mutation, IDH1(R132H) has been served as a predictive marker of glioma patients. The recently developed droplet digital PCR (ddPCR) technique generates a large amount of nanoliter-sized droplets, each of which carries out a PCR reaction on one template. Therefore, ddPCR provides high precision and absolute quantification of the nucleic acid target, with wide applications for both research and clinical diagnosis. In the current study, we collected 62 glioma tissue samples (Grade II to IV) and detected IDH1 mutations by Sanger direct sequencing, ddPCR, and quantitative real-time PCR (qRT-PCR). With the results from Sanger direct sequencing as the standard, the characteristics of ddPCR were compared with qRT-PCR. The data indicated that ddPCR was much more sensitive and much easier to interpret than qRT-PCR. Thus, we demonstrated that ddPCR is a reliable and sensitive method for screening the IDH mutation. Therefore, ddPCR is able to applied clinically in predicting patient prognosis and selecting effective therapeutic strategies. Our data also supported that the prognosis of Grade II and III glioma was better in patients with an IDH mutation than in those without mutation.
Activity Enhancement of WO3-Promoted Ir/SiO2 Catalysts by High-Temperature Calcination for the Selective Reduction of NO with CO (2009)

Abstract The catalytic activity of WO3-promoted Ir/SiO2 for the selective reduction of NO with CO in the presence of excess O2 is strongly dependent on the catalyst calcination conditions in the preparation process. WO3/Ir/SiO2 catalyst prepared by air calcination showed higher activity than that prepared by H2 reduction. The activity of WO3/Ir/SiO2 catalyst prepared by air calcination was also found to increase with increasing calcination temperature up to 1073 K; however, a further increase in the temperature to 1173 K caused a decrease in the NO reduction activity, although very high selectivity was observed for this catalyst. The lack of a major difference in the apparent activation energy for NO reduction suggests that NO reduction occurs at the same reaction sites, irrespective of calcination temperature. On the other hand, the apparent activation energy for CO oxidation increased with increased calcination temperature, suggesting that the reaction sites for CO oxidation change according to calcination temperature. Catalyst characterizations revealed that iridium species interacting strongly with WO3 are preferentially created by high-temperature air calcination. A combination of partially reduced iridium species (IrO2−x) and WO3 (IrO2−x–WO3) was concluded to act as catalytically active sites of WO3/Ir/SiO2 for NO reduction.
Portal vein air embolization after blunt abdominal trauma: a case report and review of the literature (2002)

Gas in the portal vein is a rare and often fatal condition in surgical patients. However, the presence of gas in the mesenteric and portal veins in association with abdominal trauma is a transient incidental finding that resolves spontaneously. We describe a young patient with Crohn's disease who suffered air embolism of the portal veins secondary to blunt abdominal trauma. The condition was clinically benign and resolved spontaneously. The pathogenesis is discussed and a review of the literature is provided.
Label-free lipidome study of paraventricular thalamic nucleus (PVT) of rat brain with post-traumatic stress injury by Raman imaging (2020)

Post-traumatic stress disorder (PTSD) is a widespread psychiatric injury that develops serious life-threatening symptoms like substance abuse, severe depression, cognitive impairments, and persistent anxiety. However, the mechanisms of post-traumatic stress injury in brain are poorly understood due to the lack of practical methods to reveal biochemical alterations in various brain regions affected by this type of injury. Here, we introduce a novel method that provides quantitative results from Raman maps in the paraventricular nucleus of the thalamus (PVT) region. By means of this approach, we have shown a lipidome comparison in PVT regions of control and PTSD rat brains. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry was also employed for validation of the Raman results. Lipid alterations can reveal invaluable information regarding the PTSD mechanisms in affected regions of brain. We have showed that the concentration of cholesterol, cholesteryl palmitate, phosphatidylinositol, phosphatidylserine, phosphatidylethanolamine, sphingomyelin, ganglioside, glyceryl tripalmitate and sulfatide changes in the PVT region of PTSD compared to control rats. A higher concentration of cholesterol suggests a higher level of corticosterone in the brain. Moreover, concentration changes of phospholipids and sphingolipids suggest the alteration of phospholipase A2 (PLA2) which is associated with inflammatory processes in the brain. Our results have broadened the understanding of biomolecular mechanisms for PTSD in the PVT region of the brain. This is the first report regarding the application of Raman spectroscopy for PTSD studies. This method has a wide spectrum of applications and can be applied to various other brain related disorders or other regions of the brain.
Fast music retrieval using polyphonic binary feature vectors (2003)

We propose a method for retrieving similar music from a polyphonic-music audio database using a polyphonic audio signal as a query. In this task, we must consider similarities among polyphonic signals of the music, and achieve quick retrieval. Therefore, we first introduce the polyphonic binary feature vector to represent the presence of multiple notes. This feature is suitable for the search based on the similarities among polyphonic audio signals. Then, we propose a new search method, which is quicker than the exhaustive use of DP matching. The search is accelerated using a "similarity matrix" to limit the search space. Experiments using a test database containing 216 music pieces show that the search accuracy of the proposed feature is 89%, which is approximately 26% higher than that of the conventional spectrum feature. It is also shown that the new search method retrieves similar music without significant accuracy degradation as well as the exhaustive search does and the computational complexity of the new search method is about 1/4 that of exhaustive search.