gebhart/patrepeval huggingface dataset:
A Pilot Study of Catheter-Based Ultrasound Hyperthermia with HDR Brachytherapy for Treatment of Locally Advanced Cancer of the Prostate and Cervix (2011)

Interstitial and endocavity ultrasound devices have been developed specifically for applying hyperthermia within temporary HDR brachytherapy implants during radiation therapy. Catheter‐based ultrasound applicators are capable of 3D spatial control of heating in both angle and length of the devices, with enhanced radial penetration of heating compared to other hyperthermia technologies. A pilot study of the combination of catheter based ultrasound with HDR brachytherapy for locally advanced prostate and cervical cancer has been initiated, and preliminary results of the performance and heating distributions are reported herein. The treatment delivery platform consists of a 32 channel RF amplifier and a 48 channel thermocouple monitoring system. Controlling software can monitor and regulate frequency and power to each transducer section as required during the procedure. Interstitial applicators consist of multiple transducer sections of 2–4 cm length×180 deg and 3–4 cm×360 deg. heating patterns to be inserted in specific placed 13g implant catheters. The endocavity device, designed to be inserted within a 6 mm OD plastic tandem catheter within the cervix, consists of 2–3 transducers x dual 180 or 360 deg sectors. 3D temperature based treatment planning and optimization is dovetailed to the HDR optimization based planning to best configure and position the applicators within the catheters, and to determine optimal base power levels to each transducer section. To date we have treated eight cervix implants and four prostate implants. 100% of treatments achieved a goal of >60 min duration, with therapeutic temperatures achieved in all cases. Thermal dosimetry within the hyperthermia target volume (HTV) and clinical target volume (CTV) are reported. Catheter‐based ultrasound hyperthermia with HDR appears feasible with therapeutic temperature coverage of the target volume within the prostate or cervix while sparing surrounding more sensitive regions.
Evidence that the Human Innate Immune Peptide LL-37 may be a Binding Partner of Amyloid-β and Inhibitor of Fibril Assembly (2017)

Based on this body of evidence, we propose that LL-37 and Aβ42 may be natural binding partners, which implies that balanced (or unbalanced) spatiotemporal expression of the two peptides could impact AD initiation and progression.
Bacterial genotyping by 16S rRNA mass cataloging (2006)

Cluster analysis based on comparison of mass spectrometric observables using the spectral coincidence function is an extremely useful tool for determining the genetic affinity of an unknown bacterium. Additionally, fragmentation patterns can determine within hours if an unknown isolate is potentially a known pathogen among thousands of possible organisms, and if so, which one.
Harnessing wireless data from the containment of a nuclear power plant (2013)

Over the last ten years, wireless technologies have become increasingly popular in industrial environments for process measurement, condition monitoring, predictive maintenance, plant safety, internal communications, and other applications [1]. Although the nuclear industry is traditionally slower than other industries to implement wireless technologies, U.S. nuclear power plants (NPPs) are under increasing pressure to modify their maintenance practices to keep aging equipment functioning. Advancements in technology, such as portable analyzers, smart sensors, and wireless communication, have helped alleviate the burden of performing periodic predictive maintenance.
Inversion by reverse‐time extrapolation and a new imaging principle (1986)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1986Inversion by reverse‐time extrapolation and a new imaging principleAuthors: Cengiz EsmersoyCengiz EsmersoySchlumberger‐Doll Researchhttps://doi.org/10.1190/1.1892990 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1892990FiguresReferencesRelatedDetailsCited byFrequency-domain finite-difference amplitude-preserving migrationGeophysical Journal International, Vol. 157, No. 3Migration with correction for transmission losses in arbitrary inhomogeneous mediaMartijn Frijlink and Kees Wapenaar3 January 2005 SEG Technical Program Expanded Abstracts 1986 ISSN (print):1052-3812 ISSN (online):1949-4645 Copyright: 1986 Pages: 715 publication data© 1986 Copyright © 1986 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 07 Mar 2005 CITATION INFORMATION Cengiz Esmersoy, (1986), "Inversion by reverse‐time extrapolation and a new imaging principle," SEG Technical Program Expanded Abstracts : 608-611. https://doi.org/10.1190/1.1892990 Plain-Language Summary PDF DownloadLoading ...
A method for source-microphone range estimation in reverberant environments, using an array of microphones of unknown relative position (2006)

Estimating the range between an acoustic source and a microphone is a central problem in microphone-array processing. Although many approaches have been proposed in the literature, these tend to require knowledge of the relative microphone positions. We propose a range estimation method, for use in reverberant environments and where the relative positioning of the elements of a microphone-array is unknown. We demonstrate the effectiveness of this method under real, reverberant conditions.
Measurement of an adhesion molecule as an indicator of inflammatory disease activity: Up‐regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis (1991)

The hyaluronate receptor (CD44) molecule is a multifunctional cell surface protein involved in T cell activation, monocyte cytokine release, fibroblast locomotion, and lymphocyte binding to high endothelial venules. To study the roles CD44 molecules play in inflammatory synovitis, we measured expression of CD44 in inflamed and noninflamed synovial fluid and tissue, using indirect immunofluorescence assays on tissue sections and quantitative Western blot analysis. The ability of purified CD44 protein to modulate T cell responses was tested in T cell activation assays in which CD44-containing liposomes were added in vitro. CD44 was widely expressed on many synovial cell types, and synovial tissue from rheumatoid arthritis (RA) patients contained 3.5 times more CD44 than tissue from osteoarthritis patients and 10.7 times more than tissue from patients with joint trauma. The level of soluble CD44 in RA synovial fluid was elevated only in fluids with low cell counts (less than or equal to 7,000/mm3), and not in RA synovial fluid with higher cell counts. Soluble purified CD44 protein in liposomes partially suppressed T cell activation in vitro. These data demonstrate that CD44 is up-regulated on many synovial cell types in patients with RA, and that the level of CD44 present in synovial tissue is related to the degree of synovial inflammation. Determination of ways to inhibit the proinflammatory functions of immune cell membrane CD44 molecules may provide new therapeutic modalities for RA.
Diversity and Metabolic Potential of the Terrestrial Mud Volcano Microbial Community with a High Abundance of Archaea Mediating the Anaerobic Oxidation of Methane (2021)

Terrestrial mud volcanoes (TMVs) are important natural sources of methane emission. The microorganisms inhabiting these environments remain largely unknown. We studied the phylogenetic composition and metabolic potential of the prokaryotic communities of TMVs located in the Taman Peninsula, Russia, using a metagenomic approach. One of the examined sites harbored a unique community with a high abundance of anaerobic methane-oxidizing archaea belonging to ANME-3 group (39% of all 16S rRNA gene reads). The high number of ANME-3 archaea was confirmed by qPCR, while the process of anaerobic methane oxidation was demonstrated by radioisotopic experiments. We recovered metagenome-assembled genomes (MAGs) of archaeal and bacterial community members and analyzed their metabolic capabilities. The ANME-3 MAG contained a complete set of genes for methanogenesis as well as of ribosomal RNA and did not encode proteins involved in dissimilatory nitrate or sulfate reduction. The presence of multiheme <i>c</i>-type cytochromes suggests that ANME-3 can couple methane oxidation with the reduction of metal oxides or with the interspecies electron transfer to a bacterial partner. The bacterial members of the community were mainly represented by autotrophic, nitrate-reducing, sulfur-oxidizing bacteria, as well as by fermentative microorganisms. This study extends the current knowledge of the phylogenetic and metabolic diversity of prokaryotes in TMVs and provides a first insight into the genomic features of ANME-3 archaea.
Estimating magnetic susceptible from EMI data (2007)

Studies have showed that magnetically susceptible soils significantly affect on the EMI sensors performances, which in return reduce the sensors discrimination capabilities. In order to improve EMI sensors detection and discrimination performances first soil's magnetic susceptibility needs to be estimated, and then the soils EMI responses have to be taken into account during geophysical data inversion procedure. Until now the soil's magnetic susceptibility is determined using a tiny amount (up to 15 mg) of soil's probe. This approach in many cases does not represent effective magnetic susceptibility that affects on the EMI sensors performances. This paper presents an approach for estimating soil's magnetic susceptibility from low frequency electromagnetic induction data and it is designed namely for the GeoPhex frequency domain GEM-3 sensor. In addition, a numerical code called the method auxiliary sources (MAS) is employed for establishing relation between magnetically susceptible soil's surface statistics and EMI scattered field. Using the MAS code EMI scatterings are studied for magnetically susceptible soils with two types of surfaces: body of revolution (BOR) and 3D rough surface. To demonstrate applicability of the technique first the magnetic susceptibility is inverted from frequency domain data that were collected at Cold Regions Research and Engineering Laboratory's test-stand site. Then, several numerical results are presented to demonstrate the relation between surface roughness statistic and EMI scattered fields.
Advancements in the SIS Process (2003)

Selective Inhibition of Sintering (SIS) is a new layer-based rapid prototyping process. This paper reports the progress in research and development of the SIS process. Specific printer path generation method, experimentation with various powder and inhibitor materials, and systematic models leading to optimum performance given various factors affecting part strength, surface quality, and dimensional accuracy are presented.
An extended EigenAnt colony system applied to the sequential ordering problem (2014)

The EigenAnt Ant Colony System (EAAS) model is an Ant Colony Optimization (ACO) model based on the EigenAnt algorithm. In previous work, EAAS was found to perform competitively with the Enhanced Ant Colony System (EACS) algorithm, a state-of-the-art method for the Sequential Ordering Problem (SOP). In this paper, we extend EAAS by increasing the amount of stochasticity in its solution construction procedure. In experimental results on the SOPLIB instance library, we find that our proposed method, called Probabilistic EAAS (PEAAS), performs better than both EAAS and EACS. The non-parametric Friedman test is applied to determine statistical significance.
Mouse Genome Engineering Using Designer Nucleases (2014)

Transgenic mice carrying site-specific genome modifications (knockout, knock-in) are of vital importance for dissecting complex biological systems as well as for modeling human diseases and testing therapeutic strategies. Recent advances in the use of designer nucleases such as zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) 9 system for site-specific genome engineering open the possibility to perform rapid targeted genome modification in virtually any laboratory species without the need to rely on embryonic stem (ES) cell technology. A genome editing experiment typically starts with identification of designer nuclease target sites within a gene of interest followed by construction of custom DNA-binding domains to direct nuclease activity to the investigator-defined genomic locus. Designer nuclease plasmids are in vitro transcribed to generate mRNA for microinjection of fertilized mouse oocytes. Here, we provide a protocol for achieving targeted genome modification by direct injection of TALEN mRNA into fertilized mouse oocytes.
Energetic optimization of automotive thermal systems using mixed-integer programming and model predictive control (2013)

One of the biggest shortcomings of Electric Vehicles (EV) is related to the range of their battery. This problem can become even more crucial while using some important features of the car, such as those regarding the thermal comfort of the cabin. While highly efficient systems such as heat pumps can be used to overcome this problem, their performance can yet be optimized if combined with some other thermal actuators. To this aim, this paper proposes a Mixed-Integer optimization strategy based on Model Predictive Control (MPC). The results give substantial gains using both linear and non-linear models.
The protein Deleted in Breast Cancer-1 (DBC1) regulates vascular response and formation of aortic dissection during Angiotensin II infusion (2020)

Cardiovascular diseases are among the main causes of morbimortality in the adult population. Among them, hypertension is a leading cause for stroke, heart disease and kidney failure. Also, as a result of arterial wall weakness, hypertension can lead to the development of dissecting aortic aneurysms, a rare but often fatal condition if not readily treated. In this work, we investigated the role of DBC1 in the regulation of vascular function in an ANGII-induced hypertension mouse model. We found that WT and DBC1 KO mice developed hypertension in response to ANGII infusion. However, DBC1 KO mice showed increased susceptibility to develop aortic dissections. The effect was accompanied by upregulation of vascular remodeling factors, including MMP9 and also VEGF. Consistent with this, we found decreased collagen deposition and elastic fiber fragmentation, suggesting that increased expression of MMPs in DBC1 KO mice weakens the arterial wall, promoting the formation of aortic dissections during treatment with ANGII. Finally, DBC1 KO mice had reduced cell proliferation in the intima-media layer in response to ANGII, paralleled with an impairment to increase wall thickness in response to hypertension. Furthermore, VSMC purified from DBC1 KO mice showed impaired capacity to leave quiescence, confirming the in vivo results. Altogether, our results show for the first time that DBC1 regulates vascular response and function during hypertension and protects against vascular injury. This work also brings novel insights into the molecular mechanisms of the development of aortic dissections.
A statistical model-based technique for accounting for prostate gland deformation in endorectal coil-based MR imaging (2012)

In prostate brachytherapy procedures, combining high-resolution endorectal coil (ERC)-MRI with Computed Tomography (CT) images has shown to improve the diagnostic specificity for malignant tumors. Despite such advantage, there exists a major complication in fusion of the two imaging modalities due to the deformation of the prostate shape in ERC-MRI. Conventionally, nonlinear deformable registration techniques have been utilized to account for such deformation. In this work, we present a model-based technique for accounting for the deformation of the prostate gland in ERC-MR imaging, in which a unique deformation vector is estimated for every point within the prostate gland. Modes of deformation for every point in the prostate are statistically identified using a set of MR-based training set (with and without ERC-MRI). Deformation of the prostate from a deformed (ERC-MRI) to a non-deformed state in a different modality (CT) is then realized by first calculating partial deformation information for a limited number of points (such as surface points or anatomical landmarks) and then utilizing the calculated deformation from a subset of the points to determine the coefficient values for the modes of deformations provided by the statistical deformation model. Using a leave-one-out cross-validation, our results demonstrated a mean estimation error of 1mm for a MR-to-MR registration.
ChemInform Abstract: Kinetic Control of Intralayer Cobalt Coordination in Layered Hydroxides: Cooct1‐0.5xCotetx (OH)2(Cl)x(H2O)n. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A minimax method for function interpolation using an SLI structure (2002)

We derive a closed form solution to the problem of finding an optimal grid structure for sequential linear interpolation (SLI) of a 3-D function. The criterion of optimality is to minimize the maximum absolute interpolation error. The approach we take is to equate the interpolation error within each interpolated cell. We compare the performance of our method with that of a previously developed iterative method.
Heart-Reactive Antibody: An Index of Cardiac Rejection in Human Heart Transplantation (1970)

Indirect immunofluorescent techniques used for detection of heart-reactive antibody have been used in both human and experimental cardiac transplantation. Definite evidence is presented which demonstrates the presence of circulating heart-reactive antibody preceding clinical or laboratory evidence of cardiac rejection. In all patients who lived longer than one week and died of cardiac rejection, an increase in titers of heart-reactive antibody were present prior to obvious signs of rejection and death. Immunosuppressive therapy, both experimentally and clinically, has been demonstrated to alter the titer of circulating heart-reactive antibody. Much work is needed to clarify the significance of this heart-reactive antibody in the mechanism of rejection. However, the presence of heart-reactive antibody in patients after cardiac transplantation appears to be a valuable aid in monitoring cardiac rejection.
Parallel transmit pulse design for saturation homogeneity (PUSH) for magnetization transfer imaging at 7T (2022)

The proposed PUSH method obtains more uniform and higher MT contrast than CP mode within the same specific absorption rate (SAR) budget.
DOE-Based Extraction of CMP, Active and Via Fill Impact on Capacitances (2008)

Chemical-mechanical polishing (CMP), active and via fills have become indispensable aspects of semiconductor manufacturing. CMP fills are used to reduce metal thickness variations due to chemical-mechanical polishing. Via fills are used to improve neighboring via printability and reliability of low-k and ultra low-k dielectrics. Active region fills are used for STI CMP uniformity and stress optimization. Although modern parasitic extraction tools accurately handle grounded fills and regular interconnects, such tools use only rough approximations to assess the capacitance impact of floating fills, such as assuming that floating fills are grounded or that each fill is merged with neighboring ones. To reduce such inaccuracies, we provide a design of experiments (DOE) which complements what is possible with existing extraction tools. Through the proposed DOE set, a design or mask house can generate normalized fill tables to correct for the inaccuracies of existing extraction tools when floating fills are present. Golden interconnect capacitance values can be updated using these normalized fill tables. Our proposed DOE enables extensive analyses of fill impacts on coupling capacitances. We show through 3-D field solver simulations that the assumptions used in extractors result in significant inaccuracies. We present analyses of fill impacts for an example technology and also provide analyses using the normalized fill tables to be used in the extraction flow for three different standard fill algorithms. We also extend our analyses and methodology to via fills and active region fills, which have more recently been introduced into semiconductor design-manufacturing methodologies and for which sufficient understanding is still lacking.
Effects of Temperature on the Development of the Internal Structure of the Cetyltrimethylammonium Chloride/Cetyl Alcohol/Water System (1999)

Cetyltrimethylammonium chloride (C16CA) is added to a saturated solution containing an excess of aggregated spherical white solid globules of cetyl alcohol (C16OH) to give a semitranslucent gel (STG) spontaneously without stirring. Its internal structure was compared by morphology and thermal properties with a ternary mixture system (TMS) of the same composition but prepared by mixing and stirring at 75 °C. While dispersed particles in the TMS are multilamellar vesicles, the STG consists of anisotropic lamellae. The melting point is lower for lamellae than for vesicles because of the higher water content between lamellae. The interlamellar water content plays a critical role in the structural difference between the two assemblies.
RNA Therapeutics in Oncology: Advances, Challenges, and Future Directions (2017)

RNA-based therapeutic technologies represent a rapidly expanding class of therapeutic opportunities with the power to modulate cellular biology in ways never before possible. With RNA-targeted therapeutics, inhibitors of previously undruggable proteins, gene expression modulators, and even therapeutic proteins can be rationally designed based on sequence information alone, something that is not possible with other therapeutic modalities. The most advanced RNA therapeutic modalities are antisense oligonucleotides (ASOs) and small interfering RNAs. Particularly with ASOs, recent clinical data have demonstrated proof of mechanism and clinical benefit with these approaches across several nononcology disease areas by multiple routes of administration. In cancer, next-generation ASOs have recently demonstrated single-agent activity in patients with highly refractory cancers. Here we discuss advances in RNA therapeutics for the treatment of cancer and the challenges that remain to solidify these as mainstay therapeutic modalities to bridge the pharmacogenomic divide that remains in cancer drug discovery.