gebhart/patrepeval huggingface dataset:
Similarities and differences in properties and behavior of two H2O2-activated manganese catalysts having structures differing only by methyl and ethyl substituents (2011)

Abstract The complex [Mn(IV)(Me2EBC)(OH)2](PF6)2, in which Me2EBC is 4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane, is a remarkably selective H2O2 oxidation catalyst that has been shown to be useful in removing stains from fabrics without affecting their colors. Mn(IV) is the highest oxidation state detected and the dihydroxo complex forms a peroxyhydroxy derivative that is responsible for catalytic oxidations. Study of the diethyl homolog of this catalyst has revealed surprising differences in chemical behavior. Oxidation of this new manganese complex, Mn(Et2EBC)Cl2, using aqueous H2O2, at −30°C following removal of chloride ion, yields [Mn(Et2EBC)(OH)2](PF6)2. Above 0°C, H2O2 oxidation of Mn(Et2EBC)Cl2 oxidizes the ethyl substituents. X-ray structure determinations of Et2EBC complexes with Mn(II), Mn(III), and Mn(IV) are reported. The complex [Mn(Et2EBC)(OH)2](PF6)2 displays a surprisingly mild oxidizing potential of +0.556 V for the Mn4+/Mn3+ couple; however, its hydrogen abstraction ability for selected substrates is limited by the BDECH value of 82 kcal mol−1, the same as reported for [Mn(Me2EBC)(OH)2](PF6)2. However, unlike the methyl derivative, electrochemical results indicate a 5+/4+ couple, in addition to the expected 4+/3+ and 3+/2+ couples. The significance of these differences in behavior is discussed. Mass spectral studies have identified some products of ethyl group oxidations. Keywords: Oxidation catalystStructureManganese catalysts Acknowledgments Support by the Procter and Gamble Company is deeply appreciated, and we thank the National Science Foundation Engineering Research Center Grant (EEC-0310689) for partial support. At KU, MS analyses of the Mn(IV) complex under various conditions were performed under the guidance from R.C. Drake, and the crystal structures were determined by Dr Victor Day.
P2–057: Interactome analyses of mature gamma‐secretase complexes reveals distinct molecular environments of presenilin paralogs and preferential binding of signal peptide peptidase to PS2 (2013)

γ-Secretase plays a pivotal role in the production of neurotoxic amyloid β-peptides (Aβ) in Alzheimer's disease (AD) and consists of a heterotetrameric core complex that includes the aspartyl intramembrane protease presenilin (PS). The human genome codes for two presenilin paralogs. To elucidate whether PS mutations associated with early-onset AD affect the molecular environment of mature γ-secretase complexes and understand the causes for distinct phenotypes of PS paralog deficient mice, quantitative interactome comparisons were undertaken. Brains of mice engineered to express wild-type or mutant PS1, or HEK293 cells stably expressing PS paralogs with N-terminal tandem-affinity purification (TAP) tags served as biological source materials. The analyses revealed novel interactions of the γ-secretase core complex with a molecular machinery that targets and fuses synaptic vesicles to cellular membranes and with the H + -transporting lysosomal ATPase macro-complex but uncovered no differences in the interactomes of wild-type and mutant PS1. The catenin/cadherin network was almost exclusively found associated with PS1. Another intramembrane protease, signal peptide peptidase (SPP), predominantly co-purified with PS2-containing γ-secretase complexes and was observed to influence Aβ production. The study confirmed the anticipation that a majority of presenilin candidate interactors associate with both PS1- and PS2-containing γ-secretase complexes but also revealed for the first time a small number of proteins that co-purified in a PS paralog-specific manner. It remains to be seen if the surprising association of PS2 and SPP serves the purpose to facilitate rapid removal of transmembrane stubs embedded in the lipid bilayer with opposite topologies.
Combining Short-Term and Long-Term Channel State Information Over Correlated Mimo Channels (2006)

A simple structure to exploit both long-term and partial short-term channel state information at the transmitter (CSIT) over a family of correlated multiple-antenna channels is proposed. Partial short-term CSIT in the form of a weighting matrix is obtained via a resolution-constrained feedback link, combined with a unitary transformation based on the long-term channel statistics. The feedback link is optimized to maximize the expected achievable rate under different power constraints, using vector quantization techniques. Simulation indicate the benefits of the proposed scheme in all scenarios considered.
Sound Analysis and Representation Overview (2017)

Part I Dedication: John PierceThis part is dedicated to the memory of John Robinson Pierce (1910–2002). John was a dear friend and mentor for many years, beginning in my undergraduate years at Caltech. He gave me a summer job doing lab work on electronic musical instruments, and then on digital codecs that led to my first journal article. He persuaded his colleagues at Bell Labs to take me on as an intern, even after they had objected to my “less than an A in some important subjects.” I owe my knowledge of digital signal processing to this great start with the early researchers and practitioners there. Pierce's work with George Zweig and Richard Lipes at Caltech, after I had left, became one of the most important influences on my thinking in hearing: the wave analysis that led to my filter-cascade approach to modeling the cochlea (Zweig, Lipes, and Pierce, 1976).Pierce was better known for his work outside of hearing: from his early work in traveling-wave tubes and communication satellites at Bell Labs, his coining of the word transistor, his chief technologist role at the Jet Propulsion Laboratory, his science fiction writing under the pen name J. J. Coupling, through his enormous influence on computer music starting at Bell Labs and continuing at Stanford's Center for Computer Research in Music and Acoustics (CCRMA) in the 1980s and 1990s. His regular attendance at CCRMA's weekly hearing seminar provided a huge benefit to many of us in the hearing field. He continued to conduct and publish hearing research at Stanford even in his 80s, for example providing clarity on important issues in pitch perception (Pierce, 1991).
Kinetics of CO and O2 Binding to Human Serum Albumin-Heme Hybrid (2000)

The kinetics of the CO and O(2) binding to the synthetic hemoprotein, recombinant human serum albumin (rHSA) incorporating eight 2-[8-¿N-(2-methylimidazolyl)¿octanoyloxymethyl]-5,10,15, 20-tetrakis(o-pivalamido)phenylporphinatoiron(II)s (FePs) [rHSA-FeP(8)] have been investigated by laser flash photolysis. Time dependence of the absorption change accompanied the CO rebinding to rHSA-FeP(8) was composed of three phases. The fastest component was the axial base elimination, and the long-lived biphasic decay corresponds to the direct recombination of CO to the five-N-coordinated FePs in rHSA. The rate constants of the fast and slow phases of the CO association [(fast), (slow)] were determined to be 4.9 x 10(6) M(-)(1) s(-)(1) and 6.7 x 10(5) M(-)(1) s(-)(1), respectively. The initial amplitude after the laser pulse gave the concentration ratio of the fast and slow phases (n = 3); (i) two of the eight FePs exhibited the slow rate constants and (ii) they are presumably accommodated in the second and fifth binding sites of FeP in the albumin structure. The absorption decay following the O(2) photodissociation of rHSA-FeP(8) also showed the same behavior. Thermodynamically, the large DeltaG() of the slow phase of the CO rebinding, which mainly comes from the enthalpic factor, suggests the appearance of additional steric hindrance on the central metal iron of FeP. Furthermore, orientation of the porphyrin plane in rHSA was predicted by molecular simulation, which supports the experimental data from the kinetic observations.
Sidestream bio‐P and mainstream anammox in a BNR process with upstream carbon capture (2023)

The integration of biological phosphorus removal (bio-P) and shortcut nitrogen removal (SNR) processes is challenging because of the conflicting demands on influent carbon: SNR allows for upstream carbon diversion, but this reduction of influent carbon (especially volatile fatty acids [VFAs]) prevents or limits bio-P. The objective of this study was to achieve SNR, either via partial nitritation/anammox (PNA) or partial denitrification/anammox (PdNA), simultaneously with biological phosphorus removal in a process with upstream carbon capture. This study took place in a pilot scale A/B process with a sidestream bio-P reactor and tertiary anammox polishing. Despite low influent rbCOD concentrations from the A-stage effluent, bio-P occurred in the B-stage thanks to the addition of A-stage WAS fermentate to the sidestream reactor. Nitrite accumulation occurred in the B-stage via partial denitrification and partial nitritation (NOB out-selection), depending on operational conditions, and was removed along with ammonia by the tertiary anammox MBBR, with the ability to achieve effluent TIN less than 2 mg/L. PRACTITIONER POINTS: A sidestream reactor with sufficient fermentate addition enables biological phosphorus removal in a B-stage system with little-to-no influent VFA. Enhanced biological phosphorus removal is not inhibited by intermittent aeration and is stable at a wide range of process SRTs. Partial nitritation and partial denitrification are viable routes to produce nitrite within an A/B process with sidestream bio-P, for downstream anammox in a polishing MBBR.
Processing and modelling of select PMC`s using variable frequency microwave irradiation (1995)

A new class of high temperature thermosetting isocyanate/epoxy resins have been successfully processed via Variable Frequency Microwave Energy. Considerable reduction in the curing time is brought about by the presence of the oscillating microwave electric field. Glass transition measurements were performed for both samples cured under fixed and variable frequency irradiation. A finite difference time domain (FDTD) technique models the electric field distribution inside the microwave cavity as well as inside the processed materials. The numerical technique is used for preliminary modeling of different dielectric materials.
IN VIVO AND IN VITRO DENDRITIC CELLS -INDUCED T CELLS POLARIZATION IN DIFFERENT LARGE BOWEL DISEASES (2004)

Ardito, A.; Nespoli, E.; Rescigno, M; Rimoldi, M.; Fattori, L; Nespoli, A Author Information
Electronic Structure of InTaO4 with Monoclinic Structure (2002)

Abstract From a first-principles band calculation, InTaO4 is predicted to be an indirect-gap material, because the valence band maximum (VBM) is located in the middle point on the ZD line and the conduction band minimum (CBM) in the middle point on the DX line. The valence band with the width ca. 6.0 eV is mainly constructed from O 2p orbitals hybridized with In4d5s5p and Ta5d orbitals, whereas the lower conduction band is constructed from Ta5d orbitals.
Effect Of Baseline Correction On QRS Integral Patterns In Body Surface Maps Of Ventricular Tachycardia (2005)

In a previous study we have shown that the QRS integral morphology of a 62-lead ECG can be used as a means to localize ectopic activation. Ventricular Tachycardia (VT) with frequencies 250 beats per minute) have not. This could be a serious problem when attempting to localize rapid VT. Choosing two specific instants as zero and linear interpolation of other instants (baseline correction) introduces a (possibly large) error. With increasing frequency the correlation of any single time instant during the heart cycle and the QRS integral approaches 1 or -1. This implies that any error generated by a baseline correction has the same morphology as the QRS integral and will thus not cause niorphological changes in body surface maps of rapid C’T. Therefore baseline correction does not appear to be a very critical procedure for rapid VT.
Data from Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;LMB-100 is a recombinant immunotoxin (iTox) consisting of a mesothelin-binding Fab for targeting and a modified &lt;i&gt;Pseudomonas&lt;/i&gt; exotoxin A payload. Preclinical studies showed that combining taxanes with iTox results in synergistic antitumor activity. The objectives of this phase I/II study were to determine the MTD of LMB-100 when administered with nanoalbumin bound (nab)-paclitaxel to patients with previously treated advanced pancreatic adenocarcinoma and to assess the objective response rate.&lt;/p&gt;Patients and Methods:&lt;p&gt;Patients (&lt;i&gt;n&lt;/i&gt; = 20) received fixed-dose nab-paclitaxel (125 mg/m&lt;sup&gt;2&lt;/sup&gt; on days 1 and 8) with LMB-100 (65 or 100 μg/kg on days 1, 3, and 5) in 21-day cycles for 1–3 cycles.&lt;/p&gt;Results:&lt;p&gt;Fourteen patients were treated on the dose escalation and an additional six in the phase II expansion. MTD of 65 μg/kg was established for the combination. Dose-limiting toxicity resulting from capillary leak syndrome (CLS) was seen in two of five patients treated at 100 μg/kg and one of six evaluable phase I patients receiving the MTD. Severity of CLS was associated with increases in apoptotic circulating endothelial cells. LMB-100 exposure was unaffected by anti-LMB-100 antibody formation in five of 13 patients during cycle 2. Seven of 17 evaluable patients experienced &gt;50% decrease in CA 19-9, including three with previous exposure to nab-paclitaxel. One patient developed an objective partial response. Patients with biomarker responses had higher tumor mesothelin expression.&lt;/p&gt;Conclusions:&lt;p&gt;Although clinical activity was observed, the combination was not well tolerated and alternative drug combinations with LMB-100 will be pursued.&lt;/p&gt;&lt;/div&gt;
Expression of p210bcr/abl by metallothionein promoter induced T-cell leukemia in transgenic mice (1995)

The p210bcr/abl chimeric protein is considered to be implicated in the pathogenesis of Philadelphia chromosome-positive human leukemias. To investigate its biologic function in vivo, we generated transgenic mice expressing p210bcr/abl driven by the metallothionein enhancer/promoter. Two of six founder mice and the transgenic progeny developed leukemias several months after birth. In the leukemic tissues, the expression of the p210bcr/abl transgene product was detected and the increased tyrosine-phosphorylation of cellular proteins was observed. The expressed p210bcr/abl transgene product was shown to possess an enhanced kinase activity. The leukemic cells showed rearrangements in the T-cell receptor loci, indicating that the leukemic cells were monoclonal and committed to the T-cell lineage. Polymerase chain reaction analysis for tissue distribution of p210bcr/abl expression showed that, in the transgenic line that reproducibly developed leukemias, p210bcr/abl was expressed in the hematopoietic tissues such as thymus and spleen; on the other hand, in the transgenic lines that have not developed leukemias, p210bcr/abl expression was detected only in the nonhematopoietic tissues such as the brain and kidney. These results suggest that the tumorigenicity of the p210bcr/abl chimeric protein is restricted to the hematopoietic tissues in vivo and that an event enhancing p210bcr/abl expression contributed a proliferative advantage to hematopoietic precursor cells and eventually developed T-cell leukemia in transgenic mice.
Design of 28 nm CMOS integrated transformers for a 60 GHz power amplifier (2015)

This paper describes the design of mm-wave integrated transformers and their application within a power amplifier (PA) in a 28 nm CMOS technology. The PA presents a 2-stage common-source differential topology and employs one transformer at the input and another at the output to perform single-ended to differential conversion, as well as another transformer to perform interstage matching. The baluns are sized to provide low insertion losses and high common-mode rejection rate (CMRR) as well as integrating the input and output matching networks. The designed baluns achieve minimum insertion losses better than 0.8 dB and CMRR superior to 27 dB. Thanks to the transformers, the PA presents a compact implementation, occupying only 0.037 mm2 on silicon. Measured results of the PA include a 14.8 dBm saturation power, a 12 dBm 1 dB output compression point, a 15.3 dB gain and a 20.2% peak power added efficiency.
Contribution of mechanical unloading to trabecular bone loss following non‐invasive knee injury in mice (2016)

Development of osteoarthritis commonly involves degeneration of epiphyseal trabecular bone. In previous studies, we observed 30-44% loss of epiphyseal trabecular bone (BV/TV) from the distal femur within 1 week following non-invasive knee injury in mice. Mechanical unloading (disuse) may contribute to this bone loss; however, it is unclear to what extent the injured limb is unloaded following injury, and whether disuse can fully account for the observed magnitude of bone loss. In this study, we investigated the contribution of mechanical unloading to trabecular bone changes observed following non-invasive knee injury in mice (female C57BL/6N). We investigated changes in gait during treadmill walking, and changes in voluntary activity level using Open Field analysis at 4, 14, 28, and 42 days post-injury. We also quantified epiphyseal trabecular bone using μCT and weighed lower-limb muscles to quantify atrophy following knee injury in both ground control and hindlimb unloaded (HLU) mice. Gait analysis revealed a slightly altered stride pattern in the injured limb, with a decreased stance phase and increased swing phase. However, Open Field analysis revealed no differences in voluntary movement between injured and sham mice at any time point. Both knee injury and HLU resulted in comparable magnitudes of trabecular bone loss; however, HLU resulted in considerably more muscle loss than knee injury, suggesting another mechanism contributing to bone loss following injury. Altogether, these data suggest that mechanical unloading likely contributes to trabecular bone loss following non-invasive knee injury, but the magnitude of this bone loss cannot be fully explained by disuse. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1680-1687, 2016.
Analog circuit synthesis for large, realistic cells: designing a pipelined A/D converter with ASTRX/OBLX (2002)

ASTRX/OBLX are a pair of synthesis tools that together can size high-performance analog circuit topologies to meet user supplied performance constraints. Previous approaches to cell synthesis have focused almost exclusively on small linear textbook circuits, e.g. classical op amps with 5-10 devices. In contrast, in this paper we describe our successful experiences with fully automatic synthesis of the largest analog cells automatically created to date. We design a comparator and a switched capacitor gain cell (82 devices in total), and use them to complete a realistic pipelined A/D converter.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Early Quantification of Uncertainty in the Estimation of Oil-in-Place in a Turbidite Reservoir (1993)

Abstract A description of an integrated approach to the quantification of uncertainty in the estimation of oil-in-place (OIP) is presented. The approach is unusual in two respects: firstly, the uncertainty is quantified by using traditional stochastic methods combined with an analysis of the representative of wells, secondly, the oil-in-place is calculated within a sedimentological framework, that is, by genetic sedimentary units. The former step is performed by a method known as the "Bootstrap" technique. The geostatistical modelling is constrained by detailed seismic, well and pressure data. The statistical and geostatistical methods are presented, along with a discussion of the broader implications for the quantification of uncertainty. The second part of the paper details the application of the technique to an appraisal stage field.
Skin involvement in systemic lymphoma of follicular helper T‐cell origin: A cohort study of 57 patients (2023)

Abstract Background Angioimmunoblastic T‐cell lymphoma (AITL) is one of the most frequent peripheral T‐cell lymphomas (PTCL) in western countries. Skin involvement is common and may reveal the malignancy. Despite its frequency, skin involvement in AITL has been poorly described. Objectives We aimed to analyze the cutaneous expression of PTCL of TFH origin and its prognostic impact. Methods We conducted a multicenter retrospective cohort study by retrieving histopathological reports including the mention ‘AITL’ or ‘PTCL with T‐follicular helper phenotype’ (PTCL‐TFH) from five French tertiary hospital centers. Results From 2000 to 2022, we reviewed 382 histopathological records and identified 52 AITL cases and 5 PTCL‐TFH cases with cutaneous involvement. Thirty‐two (56%) patients were males with a mean age of 63 years. Fifty‐six (98%) patients presented with lymphadenopathy, 32 (56%) splenomegaly and 17 (30%) hepatomegaly. B signs were present in 34 (60%) patients. Skin lesions were present on the lower limbs in 44 (77%) patients, trunk in 38 (67%) patients, upper limbs in 35 (61%) and head in 27 (47%). Macules and papules were the most frequent lesions found in 47 (82%) patients, followed by nodules in 10 (17%) patients, erythemato‐squamous plaques in 10 (17%) patients, purpura in 9 (16%), urticaria in 9 (16%) and blisters in 5 (9%) patients. Erythroderma affected seven patients (12%). A skin biopsy was taken in 50 patients and revealed a specific lymphomatous infiltrate in 36 cases. A dominant skin T‐cell clone was detected in 13 out of 17 (76%) patients. Among the 14 patients with a nonspecific dermatitis, various histopathological patterns were observed including interface dermatitis, psoriasiform dermatitis, vasculitis, bullous dermatitis, granulomatous dermatitis and thrombotic vasculopathy. After a median follow‐up of 24 months (range, 0–121 months), median overall survival was 121 months (95% CI, 25.2–NA). At last follow‐up, 33 patients (58%) were alive, 20 (35%) were in complete remission and 7 (12%) were in partial remission; 30 (53%) patients experienced at least one relapse, including nodal relapses in 24 (80%) cases and cutaneous relapses in 12 (40%). Conclusions This study revealed the deep heterogeneity of skin presentations in AITL. Atypical skin presentations were common and included blistering, purpuric and psoriasiform eruptions.
Influenza Virus Isolation (2012)

The isolation of influenza viruses is important for the diagnosis of respiratory diseases in lower animals and humans, for the detection of the infecting agent in surveillance programs, and is an essential element in the development and production of vaccine. Since influenza is caused by a zoonotic virus it is necessary to do surveillance in the reservoir species (aquatic waterfowls), intermediate hosts (quails, pigs), and in affected mammals including humans. Two of the hemagglutinin (HA) subtypes of influenza A viruses (H5 and H7) can evolve into highly pathogenic (HP) strains for gallinaceous poultry; some HP H5 and H7 strains cause lethal infection of humans. In waterfowls, low pathogenic avian influenza (LPAI) isolates are obtained primarily from the cloaca (or feces); in domestic poultry, the virus is more often recovered from the respiratory tract than from cloacal samples; in mammals, the virus is most often isolated from the respiratory tract, and in cases of high pathogenic avian influenza (HPAI) from the blood and internal organs of infected birds. Virus isolation procedures are performed by inoculation of clinical specimens into embryonated eggs (primarily chicken eggs) or onto a variety of primary or continuous tissue culture systems. Successful isolation of influenza virus depends on the quality of the sample and matching the appropriate culture method to the sample type.