gebhart/patrepeval huggingface dataset:
Making HIV prevention work in the north. (1993)

Meeting the challenges of diverse cultures, numerous languages and great distances, the Northwest Territories discovered innovative ways to promote AIDS prevention. This article discusses obstacles to HIV prevention and techniques used to overcome them commonly found in health services for the NWT. For example, techniques for improved service delivery include reliance on decentralized services provided by regional health boards and Community Health Representatives. Further, the challenges posed by language diversity and cultural taboos against speaking openly about sexual matters have been partially overcome through the conversion of materials and concepts into aboriginal languages which are culturally appropriate. The article specifically discusses two AIDS education campaigns in which these techniques were utilized: namely, Health is a Community Affair Campaign (or the Door-to-Door Project) and local initiatives which hosted presentations by an Aboriginal person living with AIDS.
Localization of the Origin of Arrhythmias for Ablation: From Electrocardiography to Advanced Endocardial Mapping Systems (2001)

Radiofrequency catheter ablation techniques have had a dramatic impact on the treatment of a variety of cardiac arrhythmias. However, catheter ablation of complex arrhythmias, such as intra-atrial reentry, ventricular tachycardias, and atrial fibrillation, continues to pose a major challenge. This stems from limitations of fluoroscopy and conventional catheter-based mapping techniques that limit the accurate anatomic localization of complex arrhythmogenic substrates. In this article, ECG features of complex arrhythmias are reviewed, which may facilitate the planning of an ablation procedure. The physical principles of the newly available catheter-based endocardial mapping techniques and their clinical applicability for treatment of complex arrhythmias are discussed. The role of intracardiac echocardiography to facilitate mapping and ablation is reviewed.
In Vitro Adsorption of Tear Proteins to Hydroxyethyl Methacrylate-Based Contact Lens Materials (2009)

Binding of proteins to hydroxyethyl methacrylate-based hydrogel lens surfaces is affected by charge and polymer components, and perhaps manufacturing processes. Albumin binds strongly to lens surfaces, and this may play an adverse role during contact lens wear.
EVALUATION OF BONE CEMENT INFILTRATION WITHIN VERTEBRA USING MORPHOLOGICAL PARAMETERS (2008)

To reduce vertebral fractures, emerging techniques such as vertebroplasty need to be improved by studying cement infiltration and leakage within bone. Thus we investigated samples extracted from lumbar spines using μCT to evaluate morphological parameters (trabecular thickness and separation, structural index). The specific finding is that relevant shifts of the trabecular thickness and separation Gaussian medians associated to sharpened distributions are related to donors’ age. These morphological parameters, correlated to common fluid laws, enable the prediction of bone cement flow within vertebrae and provide new ways for designing biomaterials and estimate key vertebroplasty parameters regarding time, pressure and injection site. Osteoporosis, a pathological bone decay leading to fractures, is an economical burden on society. A prevalent fracture site is the spine. To avoid vertebral fractures, emerging techniques such as vertebroplasty are used. Nevertheless, the lack of knowledge relating to cement infiltration, distribution and leakage within vertebrae during cement injection interferes with an appropriate medical practice. This study, by assessing morphological parameters, aims at a better understanding of these processes. The investigation includes size-controlled cylindrical samples (diameter of 18mm and height of 18mm), extracted from five lumbar spines (L1 to L5) of four female donors aged from forty-nine to eighty years old, analysed using micro-Computed Tomography technique (with a voxel size of 18μm*18μm*36μm) and three-dimensional computed reconstructions. Then morphological parameters such as porosity, trabecular thickness, trabecular separation, tissue surface and structural index were extracted from the reconstructed volume using dedicated software. The general findings are significant decreases in bone mass and mineral density while porosity increased and bone anisotropy remains unchanged. The specific finding is that relevant shifts of the trabecular thickness and separation Gaussian medians associated to sharpened distributions are related to donors’ age Previously determined morphological parameters correlated to common fluid laws (Stokes, Reynolds) enable the prediction of bone cement flow, infiltration and leakage during vertebroplasty and thus provide new ways for designing and evaluating biomaterials and estimating key vertebroplasty parameters regarding time, pressure and injection site. Please contact author for diagrams and graphs.
1146: Appropriate Medical Treatment After Percutaneous Nephrolithotomy can Control Active Stone Disease in the Presence of Residual Calculi (2004)

You have accessJournal of UrologyDiscussed Poster, Monday, May 10, 2004, 1:00 - 5:00 pm1 Apr 20041146: Appropriate Medical Treatment After Percutaneous Nephrolithotomy can Control Active Stone Disease in the Presence of Residual Calculi Michaella E. Maloney, W. Patrick Springhart, Charles G. Marguet, James O. L'Esperance, David M. Albala, and Glenn M. Preminger Michaella E. MaloneyMichaella E. Maloney More articles by this author , W. Patrick SpringhartW. Patrick Springhart More articles by this author , Charles G. MarguetCharles G. Marguet More articles by this author , James O. L'EsperanceJames O. L'Esperance More articles by this author , David M. AlbalaDavid M. Albala More articles by this author , and Glenn M. PremingerGlenn M. Preminger More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)38383-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1146: Appropriate Medical Treatment After Percutaneous Nephrolithotomy can Control Active Stone Disease in the Presence of Residual Calculi." The Journal of Urology, 171(4S), p. 302 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 302 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Michaella E. Maloney More articles by this author W. Patrick Springhart More articles by this author Charles G. Marguet More articles by this author James O. L'Esperance More articles by this author David M. Albala More articles by this author Glenn M. Preminger More articles by this author Expand All Advertisement PDF DownloadLoading ...
Pervasive inflammatory activation in patients with deficiency in very‐long‐chain acyl‐coA dehydrogenase (VLCADD) (2021)

Pervasive plasma cytokine upregulation and pre-activated immune cells indicate chronic inflammatory state in VLCADD. Thus, there is rationale for practical implementation of clinical assessment of inflammation and/or translational testing, or adoption, of anti-inflammatory intervention(s) for personalised disease management.
Three-Dimensional Molecular Imaging with Photothermal Optical Coherence Tomography (2013)

Optical coherence tomography (OCT) is a three-dimensional optical imaging technique that has been successfully implemented in ophthalmology for imaging the human retina, and in studying animal models of disease. OCT can nondestructively visualize structural features in tissue at cellular-level resolution, and can exploit contrast agents to achieve molecular contrast. Photothermal OCT relies on the heat-producing capabilities of antibody-conjugated gold nanoparticles to achieve molecular contrast. A pump laser at the nanoparticle resonance wavelength is used to heat the nanoparticles in the sample, and the resulting changes in the index of refraction around the nanoparticles are detected by phase-sensitive OCT. Lock-in detection of the pump beam amplitude-modulated frequency and the detector frequency allow for high-sensitivity images of molecular targets. This approach is attractive for nondestructive three-dimensional molecular imaging deep (approximately 2 mm) within biological samples. The protocols described here achieve a sensitivity of 14 parts per million (weight/weight) nanoparticles in the sample, which is sufficient to differentiate EGFR (epidermal growth factor receptor)-overexpressing cells from minimally expressing cells in three-dimensional cell constructs.
Properties of g→bb¯ at small opening angles in pp collisions with the ATLAS detector at s=13  TeV (2019)

The fragmentation of high-energy gluons at small opening angles is largely unconstrained by present measurements. Gluon splitting to b-quark pairs is a unique probe into the properties of gluon fragmentation because identified b-tagged jets provide a proxy for the quark daughters of the initial gluon. In this study, key differential distributions related to the g b b process are measured using 33 fb -1 of ffiffi ffi s p 13 TeV pp collision data recorded by the ATLAS experiment at the LHC in 2016. Jets constructed from chargedparticle tracks, clustered with the anti-k t jet algorithm with radius parameter R 0.2, are used to probe angular scales below the R 0.4 jet radius. The observables are unfolded to particle level in order to facilitate direct comparisons with predictions from present and future simulations. Multiple significant differences are observed between the data and parton shower Monte Carlo predictions, providing input to improve these predictions of the main source of background events in analyses involving boosted Higgs bosons decaying into b-quarks.
Steady-State Transcript Levels of the Porphobilinogen Deaminase Gene in Patients with Acute Intermittent Porphyria (1997)

PCR-based solid-phase minisequencing method was used to analyze the steady-state mRNA levels of the porphobilinogen deaminase gene in eight patients with acute intermittent porphyria. The patients had the earlier characterized mutations 517C --> T (R173W), 518G --> A (R173Q), 673C --> G (R225G), 673C --> T (R225X), 713T --> G (L278P), and 1073delA (frame shift). All mutations, except the missense mutation 517C --> T in exon 10, affected the steady-state transcript levels of the mutant allele. The mutant mRNA levels in lymphocytes varied from 5% to 95% of the corresponding wild-type allele levels. In contrast to the CRIM-negative mutation 517C --> T, the CRIM-positive mutation in the same codon 518G --> A resulted in reduction of the steady-state transcript level of the mutant allele to 65% of that of the normal allele. The two mutations, 673C --> G or T, affecting the same nucleotide in exon 12 also differed considerably in their effect on mRNA levels: The transcript level of the allele with a missense mutation was decreased to 80% of that of the normal allele, whereas a nonsense mutation at the same position resulted in a dramatic decrease (fivefold) in the levels of the mutant transcript. Our data showed large variations between the levels of mutant transcript in AIP patients and these variations did not correlate either to CRIM class, to the location of the disease causing mutation in the PBGD gene, or to the clinical phenotype of AIP.
Preparación de sistemas híbridos orgánicos-inorgánicos basados en silsesquioxanos oligoméricos poliédricos (POSS) para la presentación multivalente de carbohidratos (2011)

Resumen En esta memoria se describe la sintesis de un nuevo tipo de neoglicoconjugados multivalentes, que hemos denominado glico-POSS, basados en un nucleo de silsesquioxano oligomerico poliedrico (POSS) al que se unen las unidades de carbohidrato a traves de un conector. Los POSS son unas plataformas hibridas organicoinorganicas de dimensiones nanometricas y de elevada simetria. Los glico-POSS se han sintetizado a partir de POSS octafuncionalizados utilizando dos aproximaciones convergentes basadas en sendos tipos de reaccion altamente eficiente: la cicloadicion 1,3-dipolar azida-alquino catalizada por Cu(I) (CuAAC) y la reaccion de metatesis cruzada de olefinas catalizada por compuestos de rutenio. Se ha estudiado la estabilidad de los glico-POSS en agua asi como su interaccion con concanavalina A (Con A), una lectina de origen vegetal que une especificamente residuos de ?-D-manosa. Para el estudio de esta interaccion se ha empleado la resonancia de plasmon de superficie (SPR), la calorimetria de valoracion isotermica (ITC) y la difraccion de rayos X.
Data from Comparison of Effects of Diet on Mammary Cancer: Efficacy of Various Preventive Agents and Metabolomic Changes of Different Diets and Agents (2023)

&lt;div&gt;Abstract&lt;p&gt;To determine the effects of diet, rats were placed on a standard diet (4% fat) or on a modified Western (high-fat diet, HFD) diet (21% fat) at 43 days of age (DOA) and administered methylnitrosourea (MNU) at 50 DOA. Rats were administered effective (tamoxifen, vorozole, and Targretin) or ineffective (metformin and Lipitor) chemopreventive agents either by daily gavage or in the diet beginning at 57 DOA and continuing until sacrifice (190 DOA). Latency period of the tumors was determined by palpation, and multiplicity and cancer weights per rat were determined at final sacrifice. Rats on the HFD versus standard diet had: (i) a 6% increase in final body weights; (ii) significant decreases in tumor latency; and (iii) significant increases in final tumor multiplicity and average tumor weight. Tamoxifen, vorozole, and Targretin were highly effective preventive agents, whereas Lipitor and metformin were ineffective in rats on either diet. Serum was collected at 78 DOA and at sacrifice (190 DOA), and metabolomics were determined to identify the metabolite changes due to diets and effective agents. Rats given the HFD had increased levels of saturated free fatty acids (including myristate) and decreased levels of 2-aminooctanoate. Furthermore, rats on the HFD diet had increased levels of 2-aminobutyrate and decreases in glycine markers previously identified as indicators of prediabetes. Targretin increased long-chain glycophospholipids (e.g., oleyl-linoleoyl-glycerophosphocholine) and decreased primary bile acids (e.g., taurocholate). Tamoxifen increased palmitoyl-linoleoyl-glycophosphocholine and decreased stearoyl-arachidonyl glycophosphocholine. Finally, increased levels of methylated nucleotides (5-methylcytidine) and decreased levels of urea cycle metabolites (N-acetylcitrulline) were associated with the presence of mammary cancers.&lt;/p&gt;&lt;/div&gt;
[PP.25.42] NOVEL HYPERTENSION MANAGEMENT MODEL OF CARE DECREASES BLOOD PRESSURE IN WEST AFRICAN POPULATION (2017)

Objective: Background: Geographic, socioeconomic, and cultural factors create significant barriers to effective blood pressure (BP) control in many developing countries, including the Republic of Ghana where the incidence of hypertension is greater than 30%. A novel hypertension management model of care was developed to address these barriers and to improve patient management and outcomes. Methods: A total of 150 patients were enrolled and agreed to visit a participating local community pharmacy at least once per week for 6 months for a BP assessment, which included BP check, symptom questions, and medication adherence monitoring. Data were entered into a custom mobile application that generated immediate personalized feedback. Using the mobile application, the patient's primary physician viewed real-time BP assessment data, provided patients with feedback on their condition via text message, and wrote electronic prescriptions accessible to participating pharmacies. Design and method: Mean age was 57 ± 8 years; 73% were females; average time since hypertension diagnosis was 9 ± 8 years. Average baseline BP was 135 ± 18/ 84 ± 10 mmHg. After 6 months of voluntary weekly monitoring, systolic blood pressure (SBP) dropped by -4.8 ± 18.2 mmHg (p < 0.01). The subset of 58 subjects (39%) with uncontrolled pressure (SBP ? 140 mmHg) at baseline showed greater reductions in systolic pressure (-15.6 ± 17.1 mmHg; p < 0.01). The proportion of the population with uncontrolled hypertension decreased from 39% to 27% over 6 months (p = 0.02). Diastolic blood pressure also decreased. Patient compliance with weekly BP assessments was 65% and 2734 total pharmacy BP assessments were conducted. The mobile application logic directly referred 25 patients to a health facility during 33 visits (1% of pharmacy visits). No deaths occurred and six patients required inpatient hospitalization, which included one stroke. Improvement in overall health awareness was reported in 82% of the patients and 95% indicated a desire to continue using the model of care in the future. Results: A novel hypertension monitoring and remote management application resulted in decreased blood pressure that was sustained over 6 months in this West African population. Results were driven by high levels of patient compliance and satisfaction and increased access to community based care
Mortality After Periprosthetic Femur Fractures During and After Primary and Revision Total Hip Arthroplasty (2018)

Level III.
Estrogen Receptor in Adult Male Rat Liver* (1978)

A 30% ammonium sulfate precipitation has previously been utilized to partially purify the estrogen receptor(s) of female rat liver cytosol. This procedure has now been used to fractionate the estradiolbinding sites of adult male rat liver cytosol. The 30% ammonium sulfate precipitation partially purifies a group of estradiol-binding sites which have properties quite di$tinct from the large number of sites present in male liver cytosol. The partially purified male sites seem to have the same properties as the partially purified female estradiol-binding sites. They seem to be proteins that are estrogen specific and have a high estradiol affinity (Kd = 1 X 10-10 M) and a low estrogen capacity (2.3 fmol/mg liver). The estradiol-binding sites of prepubescent male rat liver cytosol have also been fractionated by 30% ammonium sulfate precipitation. The redissolved ammonium sulfate precipitates from prepubescent male rat liver cytosol contain fewer estradiolbinding sites then those from adult male or female rats. It seems that adult male as well as adult female rat liver contains estrogen receptors.
Deep Imitation Learning for Autonomous Driving in Generic Urban Scenarios with Enhanced Safety (2019)

The decision and planning system for autonomous driving in urban environments is hard to design. Most current methods manually design the driving policy, which can be expensive to develop and maintain at scale. Instead, with imitation learning we only need to collect data and the computer will learn and improve the driving policy automatically. However, existing imitation learning methods for autonomous driving are hardly performing well for complex urban scenarios. Moreover, the safety is not guaranteed when we use a deep neural network policy. In this paper, we proposed a framework to learn the driving policy in urban scenarios efficiently given offline connected driving data, with a safety controller incorporated to guarantee safety at test time. The experiments show that our method can achieve high performance in realistic simulations of urban driving scenarios.
Two LIC-Based Fast Forwarding Schemes for Explicit Routing with Scalability, Flexibility and Security (2011)

Switching and forwarding plays a very important role in packet networks, which has a decisive influence on network performances, especially on multimedia applications and real-time services. To achieve fast, flexible forwarding for both wired and wireless networks with good scalability, simplicity, security and enhancement of the network Quality of Service (QoS), this paper proposes two fast forwarding approaches on the basis of Link Interface Code (LIC), i.e., the One-way connection-based LIC Forwarding (OLICF) scheme and the Two-way connection-based LIC Forwarding (TLICF) scheme. The two proposed schemes can run over existing routing protocols and execute like explicit routing via establishing connection-oriented LIC paths in advance, where OLICF is suitable for the transmission of asymmetric flows and TLICF is more suitable for the transmission of symmetric flows including interactive real-time services. Finally, extensive experiments performed on the test network show that the proposed schemes can achieve lower end-to-end delay and higher throughput than existing methods.
Next‐generation sequencing approach to epigenetic‐based tissue source attribution (2014)

The ability to determine the tissue source of biological materials from evidence samples can be highly informative for interpreting forensic data. In this study, a previously published CE-based method to probe locus-specific DNA methylation was modified to accommodate detection using next-generation sequencing (NGS) to perform tissue source attribution. DNA samples (1 ng) from each of four different tissue types were digested with the methylation sensitive restriction endonuclease Hha1 and PCR was used to amplify an optimized subset of ten methylated loci, including positive and negative control loci. The products were prepared as NGS libraries, pooled in a multiplex assay with sample-specific barcodes, sequenced with an Illumina MiSeq, and analyzed using a k-Nearest Neighbor algorithm. With this initial effort a concordance rate of 15/16 was demonstrated from samples of varying types: semen, saliva, skin epidermis, and blood. This method also was designed to be compatible with the workflows published to date for NGS of STRs. Thus, the methylation approach described here is highly accurate and upon further validation and testing may be potentially used in practice as a confirmatory test in conjunction with other NGS protocols used in forensic laboratories.
“You Really Get Me”: Conversational AI Agents That Can Truly Understand and Help Users (2020)

Have you watched the movie Her? Have you ever wondered or wished to have an AI companion like Samantha, who could tell you what you really are, whom your best teammate may be, and which career path would be best for you? In this talk, Michelle will present a framework for building hyper-personalized, conversational Artificial Intelligent (AI) agents who can deeply understand users and responsibly guide user behavior in both virtual and real world. Through live demos, she will highlight two technical advances of the framework: (1) evidence-based personality inference and (2) model-based conversation generation. Michelle will discuss real-world applications of these agents and the wider implications of enabling hyper-personalized conversational AI agents for businesses and individuals.
Interferometric imaging of neural activity (Conference Presentation) (2020)

Small cellular deformations associated with the changes of cell potential can reveal the underlying physiological activity. Using quantitative phase microscopy, we demonstrate deformations of up to 3nm during action potential in HEK cells, and ~1nm in primary cortical neurons. Phase-resolved OCT with adaptive optics in human eyes revealed rapid axial shrinkage of the cone outer segments, starting within 0.3ms after light stimulus, followed by a gradual expansion that saturates around 500ms. Characteristics of the rapid outer segment contraction are consistent with the early receptor potential, attributed to charge movement across the outer segment disc membranes during photoisomerization.