gebhart/patrepeval huggingface dataset:
SEEK: Scoping neuromorphic architecture impact enabling advanced sensing capabilities (2022)

Many sensor modalities used for proliferation detection are expanding hyperspectrally, hyperspatially, and hypertemporally. While these assets are often tasked with high-consequence image processing tasks, the significant computational costs associated with modern AI techniques such as artificial neural networks (ANNs) limits their applicability in these environments forcing data processing elsewhere. Neuromorphic hardware, by virtue of its low-power brain-inspired communication structure and highly parallel design, offers a potential solution to this challenge, enabling greater processing at the sensor, however current research platforms have not been optimized for ANN applications. By enabling enhanced processing at the sensor, neuromorphic computing can reduce the amount of data transmitted for subsequent data science processing or analyst interpretation. Furthermore, the ability to do initial processing on the raw data at the sensor provides an opportunity to transmit higher order information such as detail of what is observed in a sensed region rather than burdening subsequent data science or analyst processing with an overwhelming amount of raw sensor readings. Instead of providing more alerts or signatures to attend to, the neuromorphic pre-processing of remotely sensed data may be filtered providing a data enrichment through machine intelligence processing helping to enable model-driven analytics. Enhanced local processing also reduces the transmission bandwidth, battery requirements, and allows the sensor to act silently for longer times. The SEEK project explores neural computing technologies, characterizing various workloads relevant to proliferation monitoring. The breadth of interrelated efforts here offers insights into the maturity and performance of many ANN and spiking neural network (SNN) approaches. Integrating these findings, this effort will produce a scoping study report providing an understanding of several facets of neuromorphic computing including - the maturity of various approaches, investigations of computational complexity factors, several analytical studies, and simulations investigating algorithm-architecture interplay. Together, this investigation will offer insight into how neuromorphic computing may impact NA-22 missions.
DE-INTERLEAVED SUBSAMPLING ARCHITECTURE FOR HOMODYNE RECEIVERS (2009)

This paper presents a de-interleaved subsampling receiver architecture suitable for homodyne receivers. The proposed topology requires only a single branch to down-convert and extract the in- phase (I) and quadrature (Q) baseband signals. Using a single- branch receiver eliminates the I=Q mismatch issue of traditional direct down-conversion receivers. The simplicity of the proposed receiver architecture makes it an alternative solution for multi-band and multi- standard applications.
ChemInform Abstract: Magnesium‐ and Titanium‐Induced Reductive Coupling of Carbonyl Compounds: Efficient Syntheses of Pinacols and Alkenes. (1988)

Abstract Finely dispersed magnesium on graphite is found to be a totally selective single‐electron transfer reagent of general utility for the reduction of various kinds of carbonyl and dicarbonyl compounds such as (II) or (V) to give the pinacols (I) or (IV).
ChemInform Abstract: Synthesis of Fragments of the Capsular Polysaccharide of Haemophilus influenzae Type b. Part 1. Preparation of Suitably Protected 1‐O‐β‐D‐Ribofuranosyl‐D‐ribitol Building Blocks. (1988)

Abstract The D‐ribitol derivative (II) which is accessible starting from D‐ribonolactone (I) is condensed with the D‐ribofuranose derivative (III) to give the compound (IVa).
The insulin‐PI3K‐Rac1 axis contributes to terminal adipocyte differentiation through regulation of actin cytoskeleton dynamics (2020)

Adipocyte differentiation is accompanied by a pronounced change in the actin cytoskeleton characterized by the reorganization of filamentous (F)-actin stress fibers into cortical F-actin structures. We previously showed that depolymerization of F-actin stress fibers induced by inactivation of RhoA-ROCK (Rho-associated kinase) signaling acts as a trigger for adipocyte differentiation. The relevance and underlying mechanism of the formation of cortical F-actin structures from depolymerized actin during adipocyte differentiation have remained unclear, however. We have now examined the mechanistic relation between actin dynamics and adipogenic induction. Transient exposure to the actin-depolymerizing agent latrunculin A (LatA) supported the formation of adipocyte-associated cortical actin structures and the completion of terminal adipocyte differentiation in the presence of insulin, whereas long-term exposure to LatA prevented such actin reorganization as well as terminal adipogenesis. Moreover, these effects of insulin were prevented by inhibition of phosphatidylinositol 3-kinase (PI3K)-Rac1 signaling and the actin-related protein 2/3 (Arp2/3) complex which is a critical component of the cortical actin networks. Our findings thus suggest that the insulin-PI3K-Rac1 axis leads to the formation of adipocyte-associated cortical actin structures which is essential for the completion of adipocyte differentiation.
Exploring cyber physical data streams using Radial Pixel Visualizations (2012)

Cyber physical systems (CPS), such as smart buildings and data centers, are richly instrumented systems composed of tightly coupled computational and physical elements that generate large amounts of data. To explore CPS data and obtain actionable insights, we construct a Radial Pixel Visualization (RPV) system, which uses multiple concentric rings to show the data in a compact circular layout of small polygons (pixel cells), each of which represents an individual data value. RPV provides an effective visual representation of locality and periodicity of the high volume, multivariate data streams, and seamlessly combines them with the results of an automated analysis. In the outermost ring the results of correlation analysis and peak point detection are highlighted. Our explorations demonstrates how RPV can help administrators to identify periodic thermal hot spots, understand data center energy consumption, and optimize IT workload.
Construction of a Stability Landscape of the CH3 Domain of Human IgG1 by Combining Directed Evolution with High Throughput Sequencing (2012)

One of the most important but still poorly understood issues in protein chemistry is the relationship between sequence and stability of proteins. Here, we present a method for analyzing the influence of each individual residue on the foldability and stability of an entire protein. A randomly mutated library of the crystallizable fragment of human immunoglobulin G class 1 (IgG1-Fc) was expressed on the surface of yeast, followed by heat incubation at 79°C and selection of stable variants that still bound to structurally specific ligands. High throughput sequencing allowed comparison of the mutation rate between the starting and selected library pools, enabling the generation of a stability landscape for the entire CH3 domain of human IgG1 at single residue resolution. Its quality was analyzed with respect to (i) the structure of IgG1-Fc, (ii) evolutionarily conserved positions and (iii) in silico calculations of the energy of unfolding of all variants in comparison with the wild-type protein. In addition, this new experimental approach allowed the assignment of functional epitopes of structurally specific ligands used for selection [Fc γ-receptor I (CD64) and anti-human CH2 domain antibody] to distinct binding regions in the CH2 domain.
Genomic Microsatellite Signatures Identify Germline Mismatch Repair Deficiency and Risk of Cancer Onset (2022)

LOGIC was a robust tool for the diagnosis of MMRD in multiple cancer types and in normal tissues. LOGIC may inform therapeutic cancer decisions, provide rapid diagnosis of germline MMRD, and support tailored surveillance for individuals with CMMRD.
A High Efficiency, Decoupled On-board Battery Charger with Magnetic Control (2018)

In this paper, a high efficiency, decoupled on-board battery charger is proposed. The proposed topology is composed of two LLC resonant converters sharing the same full-bridge inverter with constant switching frequency. The outputs of two LLC resonant converters are connected in series. One of the LLC resonant converters is operated at the resonant frequency, which is the highest efficiency operation point. The magnetic control is adopted for the second LLC resonant converter to fulfill the closed-loop control of charge voltage and current for constant voltage (CV) and constant current (CC) charge modes. The proposed topology can achieve zero voltage switching (ZVS) for all primary switches and zero current switching (ZCS) for all secondary diodes during both CC and CV modes. Furthermore, thanks to constant frequency operation, the electromagnetic interference (EMI) filter design is simplified. Simulation and experimental studies are presented to verify the feasibility and validity of the proposed topology.
Der Fixateur interne bei nicht-traumatischen Indikationen in der Wirbelsäulen-Chirurgie (2008)

This series includes 59 consecutive patients, 51 of whom had a minimum follow up of 2 years. The diagnosis was mechanical instability in 39, deformity in 11, and infection or tumor in 9 patients. The overall clinical results of the total group were good or fair in 88% of the patients. Pseudarthrosis occurred twice. We had on postoperative infection, one persistent and two reversible neurological complications. We found 13 broken screws and one rod breakage which had no clinical relevance. None of these asymptomatic complications required revision. The internal fixator has a great potential of correction in scoliotic and kyphotic deformities of the spine. It has not been shown to have the same potential in spondylolisthesis. A combined anterior and posterior stabilisation is needed in severe spondylolisthesis. We have found the internal fixator to provide satisfactory stability to allow fusion and good clinical results with a low rate of relevant complications.
Analysis of Lymphocyte Subsets in Human Diseases (1983)

モノクローナル抗体の出現は, ヒトのリンパ球サブセットの詳細な解析を可能にし, FACS (Fluorescence Activated Cell Sorter) による客観性・再現性の高い測定法とあいまって, ヒトの免疫学に確固とした基盤を提供した. モノクローナル抗体の臨床応用は, 診断・病因の解析・免疫動態の把握だけではなく, 治療応用とその後のモニタリングをも可能にしている. 本稿では, モノクローナル抗体とFACSを用いてヒト末梢血リンパ球サブセットの測定法ならびに各種疾患におけるリンパ球サブセットの変動とその臨床的意義について筆者らの経験をもとに報告する.
Protein Kinase A-Independent Inhibition of Proliferation and Induction of Apoptosis in Human Thyroid Cancer Cells by 8-Cl-Adenosine (2007)

8-Cl-ADO and 8-Cl-cAMP inhibit proliferation, induce cell cycle phase accumulation, and stimulate apoptosis in thyroid cancer cells. The effect of 8-Cl-cAMP is likely due to its metabolite 8-Cl-ADO, and PKA does not appear to have direct involvement in the inhibition of proliferation by 8-Cl-ADO. 8-Cl-ADO may be a useful therapeutic agent to be explored in aggressive thyroid cancer.
Solid-State NMR Investigations of Poly[(acrylonitrile)-rotaxa-(60-crown-20)] (1999)

Solid-state NMR has been used to investigate the structure, dynamics, and morphology of the polyrotaxane prepared by polymerizing acrylonitrile in the presence of 60-crown-20. For solid poly[(acrylonitrile)n-rotaxa-(60-crown-20)x] with x/n = 0.01, the 60-crown-20 was found to be phase-separated, amorphous, and highly mobile at room temperature. 2D WISE NMR revealed the presence of less mobile crown segments that were attributed to those in contact with the rigid PAN phase at the interfacial regions. Compared to unthreaded PAN, the Tg of the host backbone was slightly depressed (90 °C vs 110 °C), as measured by solid-state 1H NMR. These PAN Tg values were undetectable with DSC. Dipolar magnetization transfer (i.e., spin diffusion) experiments on the polyrotaxane revealed typical smallest diameters of 6−8 nm for the 60-crown-20 domains and NMR long periods of 20−26 nm. The long periods were compared with electron density correlation lengths computed from SAXS data. Upon heating the polyrotaxane to 80 °C, the primary change in the domain structure was a reduction in the size of the interface. A physical blend of PAN and 60c20 was also found to be phase separated, with a sharper interface than the polyrotaxane.
Optimal transcostal high-intensity focused ultrasound with combined real-time 3D movement tracking and correction (2011)

Recent studies have demonstrated the feasibility of transcostal high intensity focused ultrasound (HIFU) treatment in liver. However, two factors limit thermal necrosis of the liver through the ribs: the energy deposition at focus is decreased by the respiratory movement of the liver and the energy deposition on the skin is increased by the presence of highly absorbing bone structures. Ex vivo ablations were conducted to validate the feasibility of a transcostal real-time 3D movement tracking and correction mode. Experiments were conducted through a chest phantom made of three human ribs immersed in water and were placed in front of a 300 element array working at 1 MHz. A binarized apodization law introduced recently in order to spare the rib cage during treatment has been extended here with real-time electronic steering of the beam. Thermal simulations have been conducted to determine the steering limits. In vivo 3D-movement detection was performed on pigs using an ultrasonic sequence. The maximum error on the transcostal motion detection was measured to be 0.09 ± 0.097 mm on the anterior-posterior axis. Finally, a complete sequence was developed combining real-time 3D transcostal movement correction and spiral trajectory of the HIFU beam, allowing the system to treat larger areas with optimized efficiency. Lesions as large as 1 cm in diameter have been produced at focus in excised liver, whereas no necroses could be obtained with the same emitted power without correcting the movement of the tissue sample.
IL-15 REGULATES FAS MEDIATED APOPTOSIS. (2000)

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An agile, data‐driven approach for target selection in rTMS therapy for anxiety symptoms: Proof of concept and preliminary data for two novel targets (2023)

Our study suggests that a left-lateralized DMN is likely the primary functional network disturbed in anxiety-related disorders, which can be improved by identifying and targeting abnormal regions with a rapid, data-driven, agile aTBS treatment on an individualized basis.
Investigation of betaine as a novel psychotherapeutic for schizophrenia (2019)

ABSTRACT Betaine is known to act against various biological stresses and its levels were reported to be decreased in schizophrenia patients. Using Chdh (a gene for betaine synthesis)-deficient mice and betaine-supplemented inbred mice, we assessed the role of betaine in psychiatric pathophysiology, and its potential as a novel psychotherapeutic, by leveraging metabolomics, behavioral-, transcriptomics and DNA methylation analyses. The Chdh -deficient mice revealed remnants of psychiatric behaviors along with schizophrenia-related molecular perturbations. Betaine supplementation elicited genetic background-dependent improvement in cognitive performance, and suppressed methamphetamine (MAP)-induced behavioral sensitization. Furthermore, betaine rectified the altered antioxidative and proinflammatory responses induced by MAP and in vitro phencyclidine treatments. Notably, betaine levels were decreased in the postmortem brains from schizophrenia, and a coexisting elevated carbonyl stress, a form of oxidative stress, demarcated a subset of schizophrenia with “betaine deficit-oxidative stress pathology”. We revealed the decrease of betaine levels in glyoxylase 1 ( GLO1 )-defícient hiPSCs, which shows elevated carbonyl stress, and the efficacy of betaine in alleviating it, thus supporting a causal link between betaine and oxidative stress conditions. Furthermore, a CHDH variant, rs35518479, was identified as a cis-expression quantitative trait locus (QTL) for CHDH expression in postmortem brains from schizophrenia, allowing genotype-based stratification of schizophrenia patients for betaine efficacy. In conclusion, the present study underscores the potential benefit of betaine in a subset of schizophrenia.
A Unified Coding Framework for Delay-Insensitivity (2005)

We study the problem of delay-insensitivity from a coding point of view. We define sequencing rules, i.e., the rules dictating which symbols can follow which. For example, spacer-based encoding schemes obey a sequencing rule that requires a spacer to be inserted after each symbol conveying information. We define mathematically delay-insensitive sequencing rules and study the ones which maximize bandwidth efficiency.
Supplementary Table S1 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs (2023)

&lt;p&gt;Supplementary Table S1. Complete list of compounds screened.&lt;/p&gt;
Evolution of interlayer and intralayer magnetism in three atomically thin chromium trihalides (2019)

Significance Two-dimensional magnetic semiconductors such as CrI 3 are a new class of van der Waals material that may allow for the development of novel 2D spintronic devices. While strong magnetic anisotropy within the CrI 3 layers stabilizes ferromagnetism down to a monolayer, weak antiferromagnetic coupling between the layers gives rise to extremely large tunnel magnetoresistance. We use a combination of tunneling and magneto-optical measurements to investigate the entire 2D chromium trihalide family (CrX 3 , X = I, Br, Cl). Our results elucidate both the interlayer coupling and intralayer spin Hamiltonian for all three materials, and further demonstrate that ferromagnetism can be stabilized in monolayer CrBr 3 and bilayer CrCl 3 without strong anisotropy.
Adsorption Role in Shale Gas Recovery and the Feasibility of CO2 in Shale Enhanced Gas Recovery: A Study on Shale Gas from Saudi Arabia (2017)

Abstract Adsorption of CH4, CO2 and 10%CO2/CH4 on mature Qusaiba shale (1.81% TOC) is studied at 50, 100 and 150°C and 45 bars maximum pressure. Adsorption of CH4 was the lowest at all temperatures. As CO2 percentage increased, adsorption uptake increases concluding that CO2 is highly competitive and can be used to desorb CH4 and enhance gas recovery. Maximum adsorption uptakes were observed at 100°C because of the thermal decomposition of organic matter which opens more adsorption sites. Adsorption isotherms including Langmuir, Freundlich and BET are fitted to adsorption data. Langmuir isotherm showed the poorest fit with high errors and lowest coefficient of determination (R2). Nevertheless, Freundlich isotherm fitted the adsorption data perfectly with lowest errors and highest R2 reaching 0.999. Furthermore, adsorption thermodynamics parameters have also been determined. Heat of adsorption (ΔHads) negative values showed that adsorption is exothermic physical adsorption. Negative ΔGads showed that adsorption of CO2 is more spontaneous than CH4 with strong affinity at high temperatures. This work confirm that CO2 is viable candidate to shale gas enhanced gas recovery and Qusaiba shale can store huge amounts of CO2 especially at high temperatures.
Application of the operator expansion method to scattering from one-dimensional moderately rough Dirichlet random surfaces (1994)

A new method for computing wave scattering from rough surfaces, called the operator expansion (OE) method, has been proposed by D. M. Milder [J. Acoust. Soc. Am. 89(2), 529–541 (1991)]. In this paper, the OE method is examined in its application to acoustic scattering from one-dimensional randomly rough surfaces with Gaussian and Pierson–Moskowitz roughness spectra satisfying the pressure release (Dirichlet) boundary condition. The operator expansion solution, which is expressed in a systematic series, is found to converge rapidly and monotonically for moderately rough surfaces, that is, for surfaces whose slope-height roughness parameter khs, given by the product of acoustic wave number k, rms surface height h, and rms surface slope s, is less than about 0.25. Through comparison with a numerically exact integral equation solution, the OE method is found to be accurate over a wide range of incident and scattering angles. The method is currently used in a Monte Carlo computation of the scattering cross section, in which scattering is computed from one surface realization at a time and then averaged over 50 realizations. Nevertheless, its efficiency and accuracy in one-dimensional tests suggest that the operator expansion would be a useful method for computing scattering from two-dimensional surfaces in roughness regimes encountered in scattering of low-frequency sound from the ocean surface.
[Pathogenesis of macular edema associated with branch retinal vein occlusion and strategy for treatment]. (2010)

We summarize the pathogenesis and the treatment strategy for macular edema in patients with branch retinal vein occlusion (BRVO), focusing on the role of the cytokines. Various cytokines are involved in the pathogenesis of macular edema associated with BRVO. When BRVO occurs, it leads to retinal ischemia that induces the production of cytokines such as vascular endothelial growth factor (VEGF) by retinal cells such as glial cells and vascular endothelial cells in the occluded region affected by anoxia. These cytokines interact with each other (cytokine network) and this results in impairment of the blood-retinal barrier and an increase of vascular permeability, considered important in the development of macular edema associated with BRVO. Treatment for this condition includes triamcinolone acetonide, anti-VEGF antibody, laser therapy and vitrectomy, all of which lead to the suppression of cytokine production. To manage macular edema associated with BRVO, it is important to control cytokine production with a combination of treatments.
Method for forming perovskite layers using atmospheric pressure plasma (2023)

Improved deposition of optoelectronically active perovskite materials is provided with a two step process. In the first step, precursors are deposited on a substrate. In the second step, the deposited precursors are exposed to an atmospheric pressure plasma which efficiently cures the precursors to provide the desired perovskite thin film. The resulting films can have excellent optical properties combined with superior mechanical properties.