gebhart/patrepeval huggingface dataset:
D-GALACTOSAMINE CANINE LIVER FAILURE MODEL (1997)

Block, G D; Mazariegos, G V; Khanna, A; Chen, Y; Aggarwal, S; Scott, V L; Yin, W-Y; Kramer, D J; Wagner, R A; Amiot, B P; Patzerll, J F Author Information
Impact of preconditioning on the convergence of numerical co-channel interference approximations in heterogeneous networks (2011)

Various low-power node technologies such as relays and femtocells are considered an integral part of the heterogeneous fourth generation radio access networks. However, due to different transmit power levels, antenna configurations, and network planning strategies of such nodes, the interference characteristics in heterogeneous deployments can be significantly different than the conventional macrocell-only deployments. The variations in experienced co-channel interference levels could affect the convergence of numerical interference modeling methodologies and significantly decrease their convergence rates. In this paper, different preconditioning approaches are proposed and their impact on the convergence of numerical co-channel interference approximations is analyzed. The evaluations are performed utilizing a flexible MGF-matching method which approximates the lognormal sum distribution by a lognormal random variable, a well-known approach to model the co-channel interference in mobile cellular networks. Simulations show that the proposed preconditioning approaches can substantially increase the computational efficiency of the MGF-matching method while ensuring the convergence of the method.
Dynamics of Virus-Host Interplay in HIV-1 Replication (2006)

HIV-1, the causative agent of AIDS, is an obligate intracellular parasite that has both evolved to invade the complex human system and adapted to utilize the host machinery for its own propagation. A dynamic interaction between the virus and the host systems can be observed at every step of HIV-1 life cycle. Host factors are involved not only for mounting antiviral responses but are also hijacked by the virus to assist in its replication. The host factors are necessary for viral replication during entry, reverse transcription, nuclear import, integration, transcription, nuclear export, translation, assembly and budding. All retroviruses including HIV-1, are species-specific and the replication of the retroviruses is blocked in the restrictive host by the action of "host restriction factors". These restriction factors act as barriers to retroviral replication at various stages within the infected cell of a restrictive host. Nevertheless, HIV-1 virus has learned to subvert these antiviral responses and successfully propagate within the permissive host environment. This review article describes identification and mechanism of action of several pro- and anti-HIV-1 host factors. It is likely that we are just beginning to get a glimpse of an ongoing complex battle between the HIV-1 and the host, understanding of which should provide valuable information for the development of novel therapeutic strategies against HIV-1.
Association Between Coronary Artery Bypass Surgical Techniques and Postoperative Stroke (2019)

Background The impact of the coronary artery bypass grafting (CABG) technique (on- versus off-pump, single versus multiple aortic clamping) on postoperative neurological outcome remains a matter of controversy. The aim of this study was to assess the association between the incidence of postoperative stroke and the degree of aortic manipulation in one of the largest contemporary CABG series. Methods and Results A retrospective, multicenter, international study was conducted in 25 388 patients undergoing isolated CABG procedures with on-pump CABG (ONCAB) or off-pump CABG (OPCAB) technique including single or multiple aortic clamping. Postoperative stroke was defined as a postoperative neurological deficit lasting more than 24 hours and associated with evidence of a brain lesion on computed tomography. The degree of aortic manipulation was assumed to be higher for on-pump versus off-pump surgery and for multiple versus single or no aortic clamping. Logistic regression and propensity matching were used. ONCAB procedures were performed in 17 231 cases and OPCAB in 8157. The incidence of postoperative stroke was significantly lower in the OPCAB group even after propensity matching (0.4% OPCAB versus 1.2% ONCAB, <i>P</i>=0.02). In the ONCAB group (but not in the OPCAB arm) the use of single aortic clamping was associated with significantly reduced postoperative stroke rate (odds ratio, 0.05; 95% CI, 0.008 to 0.07 [<i>P</i><0.001]). Conclusions OPCAB and the use of single aortic clamping in the ONCAB arm were associated with a reduced incidence of postoperative stroke. Our data confirm a strong association between aortic manipulation and neurological outcome after CABG surgery.
Carbon Nanotubes: Can they become a microelectronics technology? (2004)

Carbon nanotubes (CNTs) have a large variety of properties that make them attractive for applications in microelectronics. A comparison of carbon nanotube field‐effect transistors with silicon MOSFETs shows that CNT devices outperform state‐of‐the‐art silicon transistors. A silicon technology review gives the benchmark for an assessment of the current CNT technology and identifies the growth and placement procedures that are not yet sufficient for industrial applications. Finally, the vertical CNT transistor concept is introduced which deals with the technological problems and opens a new route for 3D integration.
The effect of radiative transport on fluorescence emission (1989)

A model for radiative transport of electronic excitation energy in solution is presented and applied to the time-resolved and steady-state fluorescence of DPA (9, 10-diphenylanthracene) in benzene. The model predicts a nonexponential and wavelength-dependent decay at high concentrations, in agreement with experimental results. Recovered parameters, along with the time-resolved emission spectrum, are interpreted on the basis of a progression of the excitation with time farther into the cell, after the excitation pulse.
Expression of polyoma early gene products inE. coli (1985)

The three products of the early region of polyoma virus have been cloned for expression in E. coli using the Tac promoter. Although the identical promoter and ribosome binding site are used in each final construction, the observed level of protein expression is different for each protein. While plasmids expressing wild type T antigens as well as a plasmid expressing the truncated Py-1387T middle T antigen lacking the membrane-anchoring sequence give rise to synthesis of proteins readily detectible by 35S-methionine labeling and immunoprecipitation, only small T and the middle T of Py-1387T are made in amounts sufficient for ready detection in total cell protein. Unlike middle T expressed in animal cells, middle T produced in E. coli is not detectibly phosphorylated. Further, the E. coli protein lacks tyrosine kinase activity.
A distributed algorithm for delay-constrained unicast routing (2000)

We study the NP-hard delay-constrained least cost (DCLC) path problem. A solution to this problem is needed to provide real-time communication service to connection-oriented applications, such as video and voice. We propose a simple, distributed heuristic solution, called the delay-constrained unicast routing (DCUR) algorithm, DCUR requires limited network state information to be kept at each node: a cost vector and a delay vector. We prove DCUR's correctness by showing that it is always capable of constructing a loop-free delay-constrained path within finite time, if such a path exists. The worst case message complexity of DCUR is O(|V|/sup 2/) messages, where |V| is the number of nodes. However, simulation results show that, on the average, DCUR requires much fewer messages. Therefore, DCUR scales well to large networks. We also use simulation to compare DCUR to the optimal algorithm, and to the least delay path algorithm. Our results show that DCUR's path costs are within 10% of those of the optimal solution.
ABCB5+ mesenchymal stromal cells therapy protects from hypoxia by restoring Ca2+ homeostasis in vitro and in vivo (2023)

ABCB5<sup>+</sup> MSCs therapy can restore cellular Ca<sup>2+</sup> homeostasis, which may beneficially affect the angiogenic function of endothelial cells under hypoxia in vitro and in vivo.
Partial mGlu5 Negative Allosteric Modulator M-5MPEP Demonstrates Antidepressant-Like Effects on Sleep Without Affecting Cognition or Quantitative EEG (2021)

Selective negative allosteric modulators (NAMs) targeting the metabotropic glutamate receptor subtype 5 (mGlu<sub>5</sub>) demonstrate anxiolytic-like and antidepressant-like effects yet concern regarding adverse effect liability remains. Functional coupling of mGlu<sub>5</sub> with ionotropic <i>N</i>-methyl-D-aspartate receptors (NMDARs) represents a potential mechanism through which full inhibition leads to adverse effects, as NMDAR inhibition can induce cognitive impairments and psychotomimetic-like effects. Recent development of "partial" mGlu<sub>5</sub> NAMs, characterized by submaximal but saturable levels of blockade, may represent a novel development approach to broaden the therapeutic index of mGlu<sub>5</sub> NAMs. This study compared the partial mGlu<sub>5</sub> NAM, M-5MPEP, with the full mGlu<sub>5</sub> NAM, VU0424238 on sleep, cognition, and brain function alone and in combination with a subthreshold dose of the NMDAR antagonist, MK-801, using a paired-associates learning (PAL) cognition task and electroencephalography (EEG) in rats. M-5MPEP and VU0424238 decreased rapid eye movement (REM) sleep and increased REM sleep latency, both putative biomarkers of antidepressant-like activity. Neither compound alone affected accuracy, but 30 mg/kg VU0424238 combined with MK-801 decreased accuracy on the PAL task. Using quantitative EEG, VU0424238, but not M-5MPEP, prolonged arousal-related elevations in high gamma power, and, in combination, VU0424238 potentiated effects of MK-801 on high gamma power. Together, these studies further support a functional interaction between mGlu<sub>5</sub> and NMDARs that may correspond with cognitive impairments. Present data support further development of partial mGlu<sub>5</sub> NAMs given their potentially broader therapeutic index than full mGlu<sub>5</sub> NAMs and use of EEG as a translational biomarker to titrate doses aligning with therapeutic versus adverse effects.
Solar simulated ultraviolet radiation inactivates HCoV-NL63 and SARS-CoV-2 coronaviruses at environmentally relevant doses (2021)

The germicidal properties of short wavelength ultraviolet C (UVC) light are well established and used to inactivate many viruses and other microbes. However, much less is known about germicidal effects of terrestrial solar UV light, confined exclusively to wavelengths in the UVA and UVB regions. Here, we have explored the sensitivity of the human coronaviruses HCoV-NL63 and SARS-CoV-2 to solar-simulated full spectrum ultraviolet light (sUV) delivered at environmentally relevant doses. First, HCoV-NL63 coronavirus inactivation by sUV-exposure was confirmed employing (<i>i</i>) viral plaque assays, (<i>ii</i>) RT-qPCR detection of viral genome replication, and (<i>iii</i>) infection-induced stress response gene expression array analysis. Next, a detailed dose-response relationship of SARS-CoV-2 coronavirus inactivation by sUV was elucidated, suggesting a half maximal suppression of viral infectivity at low sUV doses. Likewise, extended sUV exposure of SARS-CoV-2 blocked cellular infection as revealed by plaque assay and stress response gene expression array analysis. Moreover, comparative (HCoV-NL63 versus SARS-CoV-2) single gene expression analysis by RT-qPCR confirmed that sUV exposure blocks coronavirus-induced redox, inflammatory, and proteotoxic stress responses. Based on our findings, we estimate that solar ground level full spectrum UV light impairs coronavirus infectivity at environmentally relevant doses. Given the urgency and global scale of the unfolding SARS-CoV-2 pandemic, these prototype data suggest feasibility of solar UV-induced viral inactivation, an observation deserving further molecular exploration in more relevant exposure models.
Preclinical Efficacy of an Antibody‐Drug Conjugate Targeting TIM‐1 in Ovarian, Renal and Lung Tumor Models (2015)

T cell immunoglobulin and mucin domain 1 (TIM‐1) is a type I transmembrane glycoprotein, also described as kidney injury molecule 1 (KIM‐1) and as hepatitis A virus cellular receptor 1 (HAVCR1). TIM‐1 has been shown to have upregulated expression in several human cancers, but has restricted expression in healthy tissues, thus it represents a promising target for antibody mediated therapy. To this end we have developed a fully human monoclonal antibody specific for the extracellular domain of TIM‐1, covalently linked to the potent cytotoxin monomethyl auristatin E (MMAE). We have designated this antibody‐drug conjugate as CDX‐014. Three TIM‐1 expressing xenograft models (Caki‐1, a renal clear cell carcinoma; IGROV‐1, an ovarian adenocarcinoma, and A549, a lung carcinoma) have been established to demonstrate the efficacy of CDX‐014 in vivo against human tumors. In all models, cells were grown in culture and then implanted subcutaneously into immunocompromised mice. When tumors reached an average of approximately 0.3cm 3 , mice were split into equivalently sized control and treatment groups. Dose dependent efficacy of CDX‐014 was shown in all models by a decreased rate of tumor growth and extended group survival. These studies support the further development of CDX‐014, including manufacturing activities and IND‐enabling studies, in order to advance towards clinical studies in clear cell carcinomas and potentially other TIM‐1 expressing tumors.
The CAVA corpus (2008)

This paper describes the acquisition and content of a new multi-modal database. Some tools for making use of the data streams are also presented. The Computational Audio-Visual Analysis (CAVA) database is a unique collection of three synchronised data streams obtained from a binaural microphone pair, a stereoscopic camera pair and a head tracking device. All recordings are made from the perspective of a person; i.e. what would a human with natural head movements see and hear in a given environment. The database is intended to facilitate research into humans' ability to optimise their multi-modal sensory input and fills a gap by providing data that enables human centred audio-visual scene analysis. It also enables 3D localisation using either audio, visual, or audio-visual cues. A total of 50 sessions, with varying degrees of visual and auditory complexity, were recorded. These range from seeing and hearing a single speaker moving in and out of field of view, to moving around a 'cocktail party' style situation, mingling and joining different small groups of people chatting.
Three Cases of Resected Lung Cancer Accompanied by Cryptococcal Infection. (1997)

1995年5月からの1年間で, 当科で切除した原発性肺癌55例の内, 術前画像診断及び術標本切り出しで, 同側肺に1cm以下の小腫瘤を認め, 肺内転移と考えた症例は4例であった.その内3例で, 指摘された小腫瘤よりクリプトコッカスの菌体を認め, 小腫瘤は肺内転移ではなかった.その3症例の年齢は43才-74才.男性2名, 女性1名.術後病期は, I期1名, IIIA期2名であった.この3例の共通事項として, 鳥類の飼育歴は無く, また術前は咳漱・疾等の自覚症状, 血液生化学検査の異常, 炎症所見等は認めなかった.肺癌の組織型はいずれも腺癌で, 肺葉切除+R2を行い, 術後はフルコナゾールを半年間投与した.画像診断にて, 肺癌と結節型クリプトコッカス症を鑑別する事は非常に困難である.確定診断のついていない肺小腫瘤に対しては, クリプトコッカス症を疑ってみる必要もあると思われた.
Frequency-Dependent Radiation Patterns Emitted By THz Plasmons On Cylindrical Metal Wires (2007)

We report on the emission patterns from THz plasmons propagating along wire waveguides. Experimental results and numerical simulations show frequency-dependent diffraction occurring at the end of the cylindrical waveguide.
Uplink burst LTE-A signal transmission on a converged millimeter-wave and RoF system (2014)

We propose a high-speed uplink burst-mode LTE-A signal transmission on a converged millimeter-wave and radio-over-fiber system. By using a newly developed burst-mode optical amplifier, we successfully transmit an uplink 5-carrier component LTE-A signal over a converged 5-m 92.5-GHz wireless link and 20-km radio-over-fiber system.
Carrier signal injection based sensorless control methods for IPM synchronous machine drives (2004)

This paper presents a comparison of carrier signal injection methods for sensorless torque and motion control of interior permanent magnet synchronous machine (IPMSM) drives. Rotor position can be identified at standstill and higher speeds by using one of two spatial saliency based high frequency carrier signal injection methods: rotating vector in the stationary frame or pulsating vector in the estimated rotor frame. Carrier currents for both rotating and pulsating voltage carrier injection are derived by using an IPMSM model for high frequency. An appropriate carrier signal extraction and a spatial saliency tracking scheme for both injection methods are developed for robust sensorless control. By interfering with the spatial saliency, saturation-induced saliencies act as disturbances to the rotor position estimation. Modeling, measurement, and analysis of the undesirable saturation-induced saliencies are presented for both carrier signal injection methods.
Chromatin-Binding Protein PHF6 Regulates Activity-Dependent Transcriptional Networks to Promote Hunger Response (2020)

Understanding the mechanisms of activity-dependent gene transcription underlying adaptive behaviors is challenging at neuronal-subtype resolution. Using cell-type specific molecular analysis in agouti-related peptide (AgRP) neurons, we reveal that the profound hunger-induced transcriptional changes greatly depend on plant homeodomain finger protein 6 (PHF6), a transcriptional repressor enriched in AgRP neurons. Loss of PHF6 in the satiated mice results in a hunger-state-shifting transcriptional profile, while hunger fails to further induce a rapid and robust activity-dependent gene transcription in PHF6-deficient AgRP neurons. We reveal that PHF6 binds to the promoters of a subset of immediate-early genes (IEGs) and that this chromatin binding is dynamically regulated by hunger state. Depletion of PHF6 decreases hunger-driven feeding motivation and makes the mice resistant to body weight gain under repetitive fasting-refeeding conditions. Our work identifies a neuronal subtype-specific transcriptional repressor that modulates transcriptional profiles in different nutritional states and enables adaptive eating behavior.
New Universality Class for Ferroelectrics (1982)

For isotropic, centrosymmetric, ferroelectric systems described by an $n&gt;1$ order parameter $\stackrel{\ensuremath{\rightarrow}}{\mathrm{p}}$, a new term in the Hamiltonian density, $w[{\stackrel{\ensuremath{\rightarrow}}{\mathrm{p}}}^{2}\ensuremath{\nabla}\ifmmode\cdot\else\textperiodcentered\fi{}\stackrel{\ensuremath{\rightarrow}}{\mathrm{p}}\ensuremath{-}\stackrel{\ensuremath{\rightarrow}}{\mathrm{p}}\ifmmode\cdot\else\textperiodcentered\fi{}\ensuremath{\nabla}({\stackrel{\ensuremath{\rightarrow}}{\mathrm{p}}}^{2})]$, is allowed. It is relevant, in the renormalization-group sense, in $d=4\ensuremath{-}\ensuremath{\epsilon}$ dimensions, when $n&lt;{n}_{0}=4\ensuremath{-}\frac{11\ensuremath{\epsilon}}{4}+O({\ensuremath{\epsilon}}^{2})$. For $n&lt;{n}_{0}$, no stable fixed points exist. It is concluded that simple ferroelectric and ferromagnetic systems are not in the same universality class and thus do not necessarily exhibit identical critical behavior.
Hepatic connexin 32 associates with nonalcoholic fatty liver disease severity (2018)

Emerging data highlight the critical role for the innate immune system in the progression of nonalcoholic fatty liver disease (NAFLD). Connexin 32 (Cx32), the primary liver gap junction protein, is capable of modulating hepatic innate immune responses and has been studied in dietary animal models of steatohepatitis. In this work, we sought to determine the association of hepatic Cx32 with the stages of human NAFLD in a histologically characterized cohort of 362 patients with NAFLD. We also studied the hepatic expression of the genes and proteins known to interact with Cx32 (known as the connexome) in patients with NAFLD. Last, we used three independent dietary mouse models of nonalcoholic steatohepatitis to investigate the role of Cx32 in the development of steatohepatitis and fibrosis. In a univariate analysis, we found that Cx32 hepatic expression associates with each component of the NAFLD activity score and fibrosis severity. Multivariate analysis revealed that Cx32 expression most closely associated with the NAFLD activity score and fibrosis compared to known risk factors for the disease. Furthermore, by analyzing the connexome, we identified novel genes related to Cx32 that associate with NAFLD progression. Finally, we demonstrated that Cx32 deficiency protects against liver injury, inflammation, and fibrosis in three murine models of nonalcoholic steatohepatitis by limiting initial diet-induced hepatoxicity and subsequent increases in intestinal permeability. <i>Conclusion:</i> Hepatic expression of Cx32 strongly associates with steatohepatitis and fibrosis in patients with NAFLD. We also identify novel genes associated with NAFLD and suggest that Cx32 plays a role in promoting NAFLD development. (<i>Hepatology Communications</i> 2018;2:786-797).
Protecting Operational Information of Incumbent and Secondary Users in FCC Spectrum Access System (2018)

Both Federal Communications Commission (FCC) and European Telecommunications Standards Institute (ETSI) support dynamic spectrum access (DSA) as an enabling technology for spectrum sharing. To effectively realize DSA in practice, users (from both defense and civil sectors) are required to share their (radio) operational information. That risks exposing their security, privacy, and business plan to unintended agents. In this paper, taking FCC's spectrum access system (SAS) as a study case, we propose a privacy-preserving scheme for DSA by leveraging encryption and obfuscation methods (PSEO). To implement PSEO, we propose an interference calculation scheme that allows users to calculate interference budget without revealing their operation information (e.g., antenna height, transmit power, location...), referred to as blind interference calculation method (BICM). BICM also reduces the computing overhead of PSEO, compared with FCC's SAS by moving interference budgeting tasks to local users and calculating it in an offline manner. Extensive detailed analysis and simulations show that our proposed PSEO is able to better protect all users' operational privacy, guaranteeing efficient spectrum utilization with less online overhead, compared with state of the art approaches.
Optimal control of engine-starts for drivability of parallel hybrid electric vehicles (2011)

The parallel hybrid electric vehicle (HEV) with a single pre-transmission electric motor (the P2 configuration) has a challenging drivability issue during engine-starts because the motor must simultaneously provide the propulsion torque demand and start the engine. The goal of this study is to present a design process to achieve optimal balance between these two conflicting goals. We first develop a control-oriented HEV powertrain model to accurately predict the engine, clutch, and vehicle dynamics. Assuming that the clutch torque can be accurately estimated and perfectly cancelled, an optimal engine-start control problem is formulated to minimize engine-start time while accurately supplying the driver torque demand simultaneously. This nonlinear constrained optimal control problem is solved numerically using Dynamic Programming (DP). DP results show that a proper constant clutch pressure level, which leads to constant torque disturbance that is easy to cancel out using the motor, can achieve near-optimal performance. Furthermore, the DP control policy is found to be time-invariant, and thus can be directly implemented in the form of a full state feedback controller.Copyright © 2011 by General Motors