gebhart/patrepeval huggingface dataset:
Nickel-catalyzed Tishchenko reaction via hetero-nickelacycles by oxidative cyclization of aldehydes with nickel(0) complex (2010)

A Ni(0)-catalyzed Tishchenko reaction which can be applied to a variety of aliphatic aldehydes (primary, secondary, tertiary) and aromatic aldehydes was developed. The reaction might proceed via a hetero-nickelacycle intermediate.
Baseband digital predistortion using subband filtering technique (2003)

This paper proposes a subband baseband digital predistortion architecture for power amplifiers operated in multi-channel wideband applications. The new architecture is composed of a cascade of a fixed nonlinear function and an adaptive linear subband filter bank. It takes advantage of subband filtering for computational complexity reduction and convergence enhancement. This will allow digital baseband predistortion to be applied to wideband signals that traditional architectures fail to handle due to the insufficient processing speed capacity of the available digital signal processors. Power amplifiers non-linear behavior changes versus temperature were used for a first attempt to evaluate this new subband predistorter performances.
An Ultra Hierarchical Clustering-Based Secure Aggregation Protocol for Wireless Sensor Networks (2011)

International audience
First demonstration of a CMOS over CMOS 3D VLSI CoolCube™ integration on 300mm wafers (2016)

For the first time, a full 3D CMOS over CMOS CoolCube™ integration is demonstrated with a top level compatible with state of the art high performance FDSOI (Fully-Depleted Silicon On Insulator) process requirements such as High-k/metal gate or raised source and drain. Functional 3D inverters with either PMOS or NMOS on the top level are highlighted. Furthermore, Si layer transfer above a 28nm W Metal 1 level of an industrial short loop and the return in a front end environment is presented, confirming the industrial compatibility of CoolCube™ integration.
Gastric ablation as a novel technique for modulating electrical conduction in the in vivo stomach (2021)

Gastric motility is coordinated by underlying bioelectrical "slow wave" activity. Slow wave dysrhythmias are associated with motility disorders, including gastroparesis, offering an underexplored potential therapeutic target. Although ablation is widely used to treat cardiac arrhythmias, this approach has not yet been trialed for gastric electrical abnormalities. We hypothesized that ablation can create localized conduction blocks and modulate slow wave activation. Radiofrequency ablation was performed on the porcine serosa in vivo, encompassing a range of parameters (55-85°C, adjacent points forming a line, 5-10 s/point). High-resolution electrical mapping (16 × 16 electrodes; 6 × 6 cm) was applied to define baseline and acute postablation activation patterns. Tissue damage was evaluated by hematoxylin and eosin and c-Kit stains. Results demonstrated that RF ablation successfully induced complete conduction block and a full thickness lesion in the muscle layer at energy doses of 65-75°C for 5-10 s/point. Gastric ablation may hold therapeutic potential for gastric electrical abnormalities in the future.<b>NEW & NOTEWORTHY</b> This study presents gastric ablation as a new method for modulating slow wave activation and propagation in vivo, by creating localized electrical conduction blocks in the stomach, validated by high-resolution electrical mapping and histological tissue analysis. The results define the effective energy dose range for creating conduction blocks, while maintaining the mucosal and submucosal integrity, and demonstrate the electrophysiological effects of ablation. In future, gastric ablation can now be translated toward disrupting dysrhythmic slow wave activation.
Optimal structure from motion: local ambiguities and global estimates (2002)

We present an analysis of SFM from the point of view of noise. This analysis results in an algorithm that is provably convergent and provably optimal with respect to a chosen norm. In particular, we cast SFM as a nonlinear optimization problem and define a bilinear projection iteration that converges to fixed points of a certain cost-function. We then show that such fixed points are "fundamental", i.e. intrinsic to the problem of SFM and not an artifact introduced by our algorithm. We classify and characterize geometrically local extrema, and we argue that they correspond to phenomena observed in visual psychophysics. Finally, we show under what conditions it is possible-given convergence to a local extremum-to "jump" to the valley containing the optimum; this leads us to suggest a representation of the scene which is invariant with respect to such local extrema.
A.I. Among Us: Agency in a World of Cameras and Recognition Systems (2019)

This paper reports on the use and perceptions of deployed A.I. and recognition social‐material assemblages in China and the USA. A kaleidoscope of “boutique” instantiations is presented to show how meanings are emerging around A.I. and recognition. A model is presented to highlight that not all recognitions are the same. We conclude by noting A.I. and recognition systems challenge current practices for the EPIC community and the field of anthropology.
JOHN LOCKE’UN SİYASET FELSEFESİNİN TEMELLERİ ÜZERİNE BİR DENEME (2013)

Klasik liberalizmin babası olarak bilinen ve Aydınlanma Çağı düşünürlerini en fazla etkileyenlerden biri kabul edilen John Locke (16321704), bir İngiliz filozofu ve doktordu. Locke, empirisizminin ilk temsilcilerinden biri olarak kabul edilmiş ve diğer taraftan da onun çalışmaları, siyaset felsefesi ve epistemoloji üzerinde büyük bir etki bırakmıştır. Onun siyaset felsefesi hakkındaki görüşleri bugün hâlâ etkisini sürdürmektedir. Bu makalenin asıl amacı ise; John Locke’un siyaset felsefesibağlamında ortaya koyduğu belli başlı temel kavramları ve fikirleri analiz etmeye çalışmaktır
Effects of step-down and step-up heating on the development of thermotolerance in a C3H mammary carcinomain vivo (1995)

The effects of step-down (SDH) and step-up heating (SUH) on the development of thermotolerance were investigated in a C3H mammary carcinoma in vivo. The endpoint was tumour growth time, i.e. the time for a tumour to reach a volume five times that of the first treatment day. SDH consisted of 44.5 degrees C/5 min followed immediately by 41.0 degrees C/120 min. SUH consisted of the same heat treatments but in reverse sequence. Thermotolerance was detected by subsequent heating at 43.5 degrees C at variable intervals following the primary SDH or SUH. The degree of thermotolerance was quantified by the thermotolerance ratio (TTR) calculated as a ratio between the slope of the dose-response curve for tumours heated at 43.5 degrees C and tumours preheated with either SDH or SUH followed by 43.5 degrees C. Both SDH and SUH induced thermotolerance. However, the maximal degree of thermotolerance and the time interval to reach maximum thermotolerance were different. For SUH maximal thermotolerance was observed at 8 h with a TTR of 3.6. For SUH, thermotolerance peaked at 24-28 h with a TTR of 7.3. In both cases thermotolerance had decayed with a 120 h interval. The SDH priming induced about 2.5 times more heat damage than SUH. The results are therefore in agreement with previous data obtained in the same tumour model by single heating showing that both the degree and the time to reach maximal thermotolerance increases with pretreatment heat damage. In addition, the results indicate that thermotolerance and thermosensitization are independent phenomena.
Investigation of ultrawideband pulses in wideband helix traveling wave tubes: Theory and simulation (2002)

Summary form only given. The study of pulse propagation and distortion in traveling wave tubes (TWTs) has many applications. First, it is an attractive "diagnostic method" to characterize important properties such as dispersion and nonlinear distortion over a broad frequency band.. Second, it is relevant to assessing the utility of TWTs as amplifiers for impulse radio, impulse radar, or other ultrawideband signal applications. We present initial results of new models for analysis and numerical simulation of transient TWT excitation. The analysis applies a 1D linear model to examine pulse propagation in a TWT, including beam loading, frequency-dependent gain, circuit dispersion and space charge effects. Nonlinear effects are investigated using a 1D dispersive time domain numerical particle-in-cell simulation. A novel method of incorporating the helix waveguide dispersion into a 1D telegrapher-like equation will be presented. Progress and plans for experimental investigations on the XWING tube will be discussed. The XWING (eXperimental WIsconsin Northrop Grumman) tube is a Northrop-Grumman custom modified wideband (2-6 GHz) traveling wave tube, which allows access to the wave as it propagates along the tube as well as access to the spent beam.
Ultrasound Prevents Renal Ischemia-Reperfusion Injury by Stimulating the Splenic Cholinergic Anti-Inflammatory Pathway (2013)

AKI affects both quality of life and health care costs and is an independent risk factor for mortality. At present, there are few effective treatment options for AKI. Here, we describe a nonpharmacologic, noninvasive, ultrasound-based method to prevent renal ischemia-reperfusion injury in mice, which is a model for human AKI. We exposed anesthetized mice to an ultrasound protocol 24 hours before renal ischemia. After 24 hours of reperfusion, ultrasound-treated mice exhibited preserved kidney morphology and function compared with sham-treated mice. Ultrasound exposure before renal ischemia reduced the accumulation of CD11b(+)Ly6G(high) neutrophils and CD11b(+)F4/80(high) myeloid cells in kidney tissue. Furthermore, splenectomy and adoptive transfer studies revealed that the spleen and CD4(+) T cells mediated the protective effects of ultrasound. Last, blockade or genetic deficiency of the α7 nicotinic acetylcholine receptor abrogated the protective effect of ultrasound, suggesting the involvement of the cholinergic anti-inflammatory pathway. Taken together, these results suggest that an ultrasound-based treatment could have therapeutic potential for the prevention of AKI, possibly by stimulating a splenic anti-inflammatory pathway.
A combined hall and stress sensor for highly accurate magnetic field sensing free from the piezo-Hall effect (2015)

This paper reports the use of a plate-like four-contact device for the simultaneous measurement of the magnetic field via the Hall effect and of the mechanical stress via the piezoresistance effect. The mechanical stress measurement is used to compensate for the piezo-Hall effect, i.e., the undesired cross-sensitivity of the magnetic sensitivity to mechanical stress. Thereby the drift of the magnetic sensitivity was reduced by a factor of 20 to 0.15% for mechanical stresses up to 75MPa and temperatures between 10°C and 60°C.
Economics of Heavy Fuels in Gas Turbines and Combined Cycles (1981)

Operating experience has established the ability of gas turbines and combined cycles to utilize heavy fuel oils for power generation economically and reliably. The technical factors related to operation of gas turbines on heavy oils are discussed and installation and operating costs are developed for each of these factors for economic evaluation. Factors influencing heavy oil use include fuel specifications and treatment to prevent corrosion of hot parts, the effects of ash deposition on turbine nozzles and buckets and on boiler heat transfer surface, turbine and boiler cleaning techniques and their use for maintaining capability, and downtime for cleaning.
A wideband 65nm CMOS transformer-coupled power amplifier for WiGig applications (2014)

This paper describes a compact two-stage pseudodifferential cascode power amplifier implemented in 7-metal-layer 65nm Low-Power CMOS process. A cascode topology is associated with wideband matching networks which combine integrated transformers and slow-wave transmission lines. The power amplifier achieves 26GHz of bandwidth from 48GHz to 74GHz, with a 1dB ripple flat gain between 50GHz and 70GHz. The circuit delivers 1dB-compressed and saturated output powers of 9.5dBm and 13dBm respectively, for a maximum power added efficiency of 6%. The active area occupies only 0.048mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
comparison of fluorescence guidance systems for ICG & IRDye800 imaging (Conference Presentation) (2019)

Fluorescence guidance systems are used for different indications, and the relevant range of concentrations and the relevant dye used varies considerably for human clinical trials. Most systems are designed for high concentration ICG imaging, where 0.1 mg/kg is injected IV and perfusion is imaged, yet other applications such as delayed uptake (or second temporal window) ICG imaging can have tissue concentrations an order of magnitude or more below this. Additionally, IRDye800 is used in both antibody imaging and small protein imaging in clinical trials, but injected doses vary from therapeutic to microdose levels. In this study, the sensitivity to both perfusion dose and microdose ranges were tested for ICG and IRDye800CW, using the Spy Elite system (Stryker) and the Solaris (Perkin Elmer). The sensitivity to ICG was significantly different and the sensitivity to IRDye800 was also different but with opposite choice of the optimal system. The concentrations tested ranged from 0.1 mg/kg down to 0.1 ug/kg. The signal to background limited the sensitivity in both cases, and the ambient light effects were significantly different in the two systems. The in vivo testing in lymphatic and vascular transport was assessed to determine limits to detection for vessel size.
A State-based Refinement Technique for Event-B (2020)

Formal models can be used to describe and reason about the behavior and properties of a given system. In some cases, it is even possible to prove that the system satisfies the given properties. This allows detecting design errors and inconsistencies early and fixing them before starting development. Such models are usually created using stepwise refinement: starting with the simple, abstract model of the system, and then incrementally refining it adding more details at each subsequent level of refinement. Top levels of the model usually describe the high-level design or purpose of the system, while the lower levels are more directly comparable with the implementation code. In this paper, we present a new, alternative refinement technique for Event-B which can simplify the development of complicated models with a large gap between high-level design and implementation.
Experimental Evaluation of Myocardial Revascularization Procedures (1966)

HAMMOND, GRAEME L. M.D.; PHOVAN, JOHN L. F.R.C.S.; AUSTEN, W. GERALD M.D. Author Information
Fast IP lookups using a two-trie data structure (2003)

IP routing table lookup has been considered as a major bottleneck for high performance routers. We propose a new way to do IP route lookups based on a so-called two trie structure. The two-trie structure shares the nodes representing the front and the rear parts of the prefixes. This results in reducing the number of nodes in the structure. Our results indicate that the memory can be saved around 27% over the standard trie while it still provides the fast lookup (around 1.6 memory accesses in the average case and 8 memory accesses in the worst case). Also, the structure is not based on any assumptions about the distribution of prefix lengths in routing tables. Thus, it can be applied to the larger addresses of IPv6 without affecting the main structure.
Preparation of an [18F]liposome using a novel ‘click’ chemistry approach (2012)

1537 Objectives Several liposome formulations in the size range of 90-100 nm are clinically approved as compositions for chemotherapeutic drug delivery, while PET imaging can provide an effective method of noninvasively tracking and quantifying liposomal biodistribution. Although a number of methods for radiolabeling liposomes with various radionuclides have been developed, the most useful radionuclide for PET imaging is F-18, although it represents a radiolabeling challenge and can be inefficient. Herein, we report a new and efficient approach to F-18 radiolabeling of a preformed liposome using ‘click’ chemistry. Methods We synthesized an F-18 labeled liposome by ‘click’ chemistry using a [18F]23-azido-1-fluoro-3, 6, 9, 12, 15, 18, 21-heptaoxatricosane hapten and a dibenzyl cyclooctyne (DBCO)-appended liposome. The DBCO-liposome was first prepared within a limited size range of 80-90nm, and then coupled with the [18F]azide ligand followed by radiolabeled liposome purification using a size-exclusion PD10 column. Results The [18F]azide ligand was synthesized in a 24% (n=12) uncorrected radiochemical yield in 50 minutes. The [18F]azide ligand and the DBCO-liposome were combined at 37°C for 45 min. The uncorrected radiochemical yield was 47% (37%-63%, n=3). The overall uncorrected radiochemical yield was 11% in a 95min synthesis time starting from [18F]fluoride. Conclusions The approach represents a new method for radiolabeling a preformed liposome with F-18. Research Support This work was funded by the intramural program of the National Institutes of Health
ChemInform Abstract: SPECIFIC ENOLATES FROM α‐AMINO KETONES (1980)

Abstract α‐Amino‐ketone (I) werden unter verschiedenen Bedingungen in die Silylenolether (II) und (III) übergeführt.
Measurement of the photostability of silicon nanoparticles under UVA and near infrared irradiation (2010)

We examine the photostability of silicon nanoparticles when they are dispersed in liquid or immobilized in gels or on surfaces. We show that the photoluminescence in static solution develops, under UV irradiation, a long-term stability at the 50% level. Under the same conditions, common dye molecules such as coumarin and stilbene quench with time at rates 8 and 50 fold faster, and exhibit no long-term stability. For the case of immobilized particles in agarose gel as well as on a quartz substrate we used two-photon near infrared femtosecond excitation at 780 nm to induce the blue luminescence. “Parking” the excitation beam, focused on such stationery particles shows that they, unlike similarly immobilized dye molecules, are highly photostable at more than 80%–90% level and do not bleach. The photostability is discussed in terms of excited state interactions and structuring of the silicon outer shell.
Welding and Weldability of Thorium-Doped Iridium Alloys (2000)

Ir-0.3%W alloys doped with thorium are currently used as post-impact containment material for radioactive fuel in thermoelectric generators that provide stable electrical power for a variety of outer planetary space exploration missions. Welding and weldability of a series of alloys was investigated using arc and laser welding processes. Some of these alloys are prone to severe hot-cracking during welding. Weldability of these alloys was characterized using Sigmajig weldability test. Hot-cracking is influenced to a great extent by the fusion zone microstructure and composition. Thorium content and welding atmosphere were found to be very critical. The weld cracking behavior in these alloys can be controlled by modifying the fusion zone microstructure. Fusion zone microstructure was found to be controlled by welding process, process parameters, and the weld pool shape.
Role of TGF-β1in Platelet-mediated Cardioprotection During Ischemia-reperfusion in Isolated Rat Hearts (1999)

Platelets protect myocardium against ischemia-reperfusion injury. This study examined the role of platelet-derived TGF-beta1 in cardioprotection during ischemia-reperfusion. Isolated Sprague Dawley rat hearts were perfused with K-H buffer and subjected to 25 min of global ischemia followed by 30 min of reperfusion. Ischemia-reperfusion resulted in myocardial dysfunction indicated by increase in CPP and LVEDP, and decrease in dLVP. Perfusion of hearts with washed platelets or supernatant of aggregated platelets attenuated (P < 0.01) of myocardial dysfunction following ischemia-reperfusion. Ischemia-reperfusion resulted in a decrease in myocardial TGF-beta1 determined by immunohistochemistry. ELISA showed an increase in latent TGF-beta1, but a decrease in active TGF-beta1. Perfusion of hearts with platelets or aggregated platelet supernatant preserved myocardial TGF-beta1 content upon ischemia-reperfusion. Perfusion of hearts with recombinant TGF-beta1 also resulted in cardioprotection following ischemia-reperfusion qualitatively similar to that observed with platelets or aggregated platelet supernatants. RT-PCR analysis showed an increase in myocardial TGF-beta1 mRNA following ischemia-reperfusion. These observations indicate that platelets protect the myocardium against ischemia-reperfusion-mediated dysfunction at least in part by releasing TGF-beta1. Increase in both TGF-beta1 mRNA and latent TGF-beta1 does not indicate a defect in the translation of mRNA. Reduction in myocardial TGF-beta1 following ischemia-reperfusion suggests a defect in the conversion of latent TGF-beta1 to active TGF-beta1.
ChemInform Abstract: DIE KONDENSATION VON BERNSTEINSAEUREANHYDRIDEN MIT SCHIFFSCHEN BASEN, BEDEUTUNG UND MECHANISMUS (1972)

Abstract Die Schiffschen Basen (I) reagieren mit Bemsteinsäureanhydrid (II) beim Erhitzen in Benzol zu einem Gemisch der cis‐/trans‐isomeren Carbonsäuren (III) und (IV).
Solid‐phase synthesis of bovine pancreatic trypsin inhibitor BPTI) and two analogues (1992)

The linear sequence of bovine pancreatic trypsin inhibitor (BPTI) has been assembled by stepwise Fmoc solid‐phase peptide synthesis on a polyethylene glycol‐polystyrene (PEG‐PS) graft support with p ‐alkoxybenzyl ester anchoring. Similar methods were used to prepare two analogues, the first with all six half‐cystine (Cys) residues replaced by α‐amino‐ n ‐butyric acid (Abu), and the second with replacement of Abu at four Cys positions while retaining the native pairing between positions 14 and 38. Following cleavage from the sup‐port, the linear molecules (reduced form) were purified by semipreparative reversed‐phase high performance liquid chromatography (HPLC). The native structure of BPTI was then formed by oxidation of a dilute solution of the protein at pH 8.7 in the presence of oxidized glutathione. The BPTI analogue with one disulfide bridge was obtained following treatment with dimethyl sulfoxide (DMSO)‐pH 6 buffer (1:9). Overall yields of homogeneous proteins were 2–4%, and further characterization was provided by amino acid analysis, sequencing, ion electrospray mass spectrometry, analytical HPLC, and capillary zone electrophoresis (CZE). Purified synthetic BPTI with the native sequence was indistinguishable from natural material by the analytical and biophysical criteria applied, including circular dichroism (CD) spectra and inhibition of trypsin action. Studies are in progress to evaluate conformational features of the analogues which respectively lack two, or all three, of the native disulfide bridges.
Cavopulmonary support with a modified cannulation technique in a failing Fontan patient (2022)

Failing Fontan patients present a unique challenge for mechanical circulatory support. We report on a 17-year-old patient with Fontan failure and preserved ventricular function who underwent mechanical cavopulmonary support using a novel cannulation technique.