gebhart/patrepeval huggingface dataset:
Self-Adaptive System Based on Field Programmable Gate Array for Extreme Temperature Electronics (2006)

Space missions often require radiation and extreme-temperature hardened electronics to survive the harsh environments beyond earth's atmosphere. Traditional approaches to preserve electronics incorporate radiation shielding, insulation and redundancy at the expense of power and weight. In this work, we report the implementation of a self-adaptive system using a field programmable gate array (FPGA) and data converters. The self-adaptive system can autonomously recover the lost functionality of a reconfigurable analog array (RAA) integrated circuit (IC). Both the RAA IC and the self-adaptive system are operating in extreme temperatures (from 120 degC down to -180degC). The RAA IC consists of reconfigurable analog blocks interconnected by several switches and programmable by bias voltages. It implements filters/amplifiers with bandwidth up to 20 MHz. The self-adaptive system controls the RAA IC and is realized on commercial-off-the-shelf (COTS) parts. It implements a basic compensation algorithm that corrects a RAA IC in less than a few milliseconds. Experimental results for the cold temperature environment (down to -180degC) demonstrate the feasibility of this approach
ChemInform Abstract: Isophthalic Acid‐Derived Dicarbothioamides as Novel Metal‐Free Catalysts in Hydrogen Bond‐Promoted Reactions. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Label-free optical detection of cells grown in 3D silicon microstructures (2013)

We demonstrate high aspect-ratio photonic crystals that could serve as three-dimensional (3D) microincubators for cell culture and also provide label-free optical detection of the cells. The investigated microstructures, fabricated by electrochemical micromachining of standard silicon wafers, consist of periodic arrays of silicon walls separated by narrow deeply etched air-gaps (50 μm high and 5 μm wide) and feature the typical spectral properties of photonic crystals in the wavelength range 1.0-1.7 μm: their spectral reflectivity is characterized by wavelength regions where reflectivity is high (photonic bandgaps), separated by narrow wavelength regions where reflectivity is very low. In this work, we show that the presence of cells, grown inside the gaps, strongly affects light propagation across the photonic crystal and, therefore, its spectral reflectivity. Exploiting a label-free optical detection method, based on a fiberoptic setup, we are able to probe the extension of cells adherent to the vertical silicon walls with a non-invasive direct testing. In particular, the intensity ratio at two wavelengths is the experimental parameter that can be well correlated to the cell spreading on the silicon wall inside the gaps.
Supplementary Tables 3 - 6 from CCT244747 Is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs (2023)

&lt;p&gt;PDF file, 79K, Supplementary Table 3 - Mouse body weights for data in Figure 4A Body Weights expressed as a percentage of the weight on day 0 for mice bearing HT29 xenografts and treated with gemcitabine (100mg/kg iv), CCT244747 (75mg/kg po) or the combination. Values are mean�SE, n= 3 to 6. Supplementary Table 4 - Mouse body weights for data in Figure 4C Body Weights expressed as a percentage of the weight on day 0 for mice bearing HT29 xenografts and treated with irinotecan (25mg/kg ip), CCT244747 (150mg/kg po) or the combination. Values are mean�SE, n= 3 to 6. Supplementary Table 5 - Mouse body weights for data in Figure 4D Body Weights expressed as a percentage of the weight on day 0 for mice bearing Calu6 xenografts and treated with gemcitabine (100 mg/kg iv), CCT244747 (75mg/kg po) or the combination. Values are mean�SE, n= 3 to 6. Supplementary Table 6 - Mouse body weights for data in Supplementary Table 2 Body Weights expressed as a percentage of the weight on day 0 for mice bearing SW620 xenografts and treated with gemcitabine (100 mg/kg iv), CCT244747 (75mg/kg po) or the combination. Values are mean�SE, n= 3 to 6.&lt;/p&gt;
Achieving symmetric Pareto Nash equilibria using biased replicator dynamics (2009)

Achieving the Nash equilibria for single objective games is known to be a computationally difficult problem. However there is a special class of equilibria called evolutionary robust equilibria which can be obtained through a special type of evolutionary dynamics called the replicator dynamics. This dynamics has special properties over the simplex, which has been studied in optimization theory to solve several combinatorial problems. In this work, we consider the essentially hard combinatorial optimization problem of computing the equilibria in games with multiple objectives. We extend the notion of replicator dynamics to handle such games. We establish proofs of dynamic stability of this modified replicator dynamics and present their relation to the Pareto Nash equilibria in multi-objective games.
Synthesis of Phase‐Pure Pb(Zn x Mg 1– x ) 1/3 Nb 2/3 O 3 up to x = 0.7 from a Single Mixture via a Soft‐Mechanochemical Route (2000)

Phase‐pure perovskite Pb(Zn x Mg 1– x ) 1/3 Nb 2/3 O 3 solid solution (PZ x M 1– x N) is obtained for x ≦ 0.7 by heating a milled stoichiometric mixture of PbO, Mg(OH) 2 , Nb 2 O 5 , and 2ZnCO 3 ·3Zn(OH) 2 ·H 2 O at 1100°C for 1 h. Percent perovskite ( f P ) with respect to total crystalline phase decreases with increasing temperature of subsequent heating then increases to 900°C for the mixtures where x ≦ 0.8 and milled for 3 h. For mixtures with x = 0.9 and x = 1, f P decreases monotonically. Curie temperature increases almost linearly with increasing x up to x = 0.7. The maximum dielectric constant at 1 kHz is 2×10 4 and 1.7×10 4 for the mixture with x = 0.4 and x = 0.7, respectively. The stabilization mechanism of strained perovskite is discussed.
A Follow-Up Study of Israeli Adolescent In-Patients (1997)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Three-dimensional collimation of in-plane-propagating light using silicon micromachined mirror (2014)

We demonstrate light collimation of single-mode optical fibers using deeply-etched three-dimensional curved micromirror on silicon chip. The three-dimensional curvature of the mirror is controlled by a process combining deep reactive ion etching and isotropic etching of silicon. The produced surface is astigmatic with out-of-plane radius of curvature that is about one half the in-plane radius of curvature. Having a 300-&mu;m in-plane radius and incident beam inplane inclined with an angle of 45 degrees with respect to the principal axis, the reflected beam is maintained stigmatic with about 4.25 times reduction in the beam expansion angle in free space and about 12-dB reduction in propagation losses, when received by a limited-aperture detector.
The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease (2019)

T helper 17 (Th17) cells produce interleukin-17 (IL-17) cytokines and drive inflammatory responses in autoimmune diseases such as multiple sclerosis. The differentiation of Th17 cells is dependent on the retinoic acid receptor-related orphan nuclear receptor RORγt. Here, we identify REV-ERBα (encoded by <i>Nr1d1</i>), a member of the nuclear hormone receptor family, as a transcriptional repressor that antagonizes RORγt function in Th17 cells. REV-ERBα binds to ROR response elements (RORE) in Th17 cells and inhibits the expression of RORγt-dependent genes including <i>Il17a</i> and <i>Il17f</i> Furthermore, elevated REV-ERBα expression or treatment with a synthetic REV-ERB agonist significantly delays the onset and impedes the progression of experimental autoimmune encephalomyelitis (EAE). These results suggest that modulating REV-ERBα activity may be used to manipulate Th17 cells in autoimmune diseases.
SIG (2015)

Recent research has shown that some software that is intended to be gender-neutral is not, in fact, equally inclusive to males and females. But little is known about how to design software in a gender-aware fashion, and existing research on gender differences relevant to software design is scattered across at least five different academic fields (e.g., psychology, computer science, education, communications, and women's studies). This research SIG will bring together female and male academics, industry researchers, and practitioners with three goals in mind: (1) to build community across research/practice boundaries; (2) to pool our knowledge on promising practices for design and evaluation of software from a gender perspective; and (3) to begin to build a shared, on-line research and literature base to support solid, well-informed progress on this important issue.
In vitro adenylate cyclase-stimulating activity predicts the occurrence of humoral hypercalcemia of malignancy in nude mice. (1988)

A number of factors have been proposed as potential mediators of the syndrome of humoral hypercalcemia of malignancy (HHM), but to date no firm cause-and-effect relationship has been established. We attempted to establish such a relationship by determining whether the presence or absence of adenylate cyclase-stimulating activity (ACSA) in the media of cultured tumor cells predicted the occurrence of the syndrome of HHM when these cell lines were grown in nude mice in vivo. Conditioned media from 35 human renal carcinoma cell lines were surveyed for ACSA in the PTH-sensitive rat osteosarcoma 17/2.8 cell assay. 12 lines were positive (mean, 13.7-fold stimulation, range, 3.0 to 44.0), and 23 lines were negative (mean, 1.2-fold stimulation, range, 0.9 to 1.5). We were successful in establishing five of the positive and six of the negative lines in three to five nude mice per line. Mice implanted with the positive lines uniformly became hypercalcemic (mean serum calcium, 15.8 mg/dl), whereas mice implanted with the negative lines uniformly remained normocalcemic (mean serum calcium, 9.5 mg/dl), in spite of comparable mean tumor size. Acid-urea tumor extracts from each of four hypercalcemic animals contained potent in vitro ACSA (mean, 15.9-fold stimulation), while 5/5 extracts from normocalcemic animals did not (mean, 1.4-fold stimulation). Our study demonstrates that in this model system in vitro ACSA is a reliable predictive marker for HHM in vivo. Whether the protein responsible for this activity is also the mediator of the bone resorption seen in HHM remains to be demonstrated.
Thermosynechococcus switches the direction of phototaxis by a c-di-GMP dependent process with high spatial resolution (2021)

Abstract Many cyanobacteria, which use light as an energy source via photosynthesis, show directional movement towards or away from a light source. However, the molecular and cell biological mechanisms for switching the direction of movement remain unclear. Here, we visualized type IV pilus-dependent cell movement in the rod-shaped thermophilic cyanobacterium Thermosynechococcus vulcanus using optical microscopy at physiological temperature and light conditions. Positive and negative phototaxis were controlled on a short time scale of 1 min. The cells smoothly moved over solid surfaces towards green light, but the direction was switched to backward movement when we applied additional blue light illumination. The switching was mediated by three photoreceptors, SesA, SesB and SesC, which have cyanobacteriochrome photosensory domains and synthesis/degradation activity of the bacterial second messenger cyclic dimeric GMP (c-di-GMP). Our results suggest that the decision-making process for directional switching in phototaxis involves light-dependent changes in the cellular concentration of c-di-GMP. Furthermore, we reveal that rod-shaped cells can move perpendicular to the light vector, indicating that the polarity can be controlled not only by pole-to-pole regulation but also within-a-pole regulation. This study provides insights into previously undescribed rapid bacterial polarity regulation via second messenger signalling with high spatial resolution.
Proximity effect correction in electron-beam lithography based on computation of critical-development time with swarm intelligence (2017)

Electron-beam lithography (EBL) is an important technique in manufacturing high-resolution nanopatterns for broad applications. However, the proximity effect in EBL can degrade the pattern quality and, thus, impact the performance of the applications greatly. The conventional proximity effect correction (PEC) methods, which employ computationally intensive cell or path removal method for development simulation, are very computational lengthy, especially for complex and large-area patterns. Here, the authors propose a novel short-range PEC method by transforming the evaluation of pattern feasibility into the shortest path problem based on the concept of critical-development time. The authors combine this evaluation algorithm with the swarm intelligence which mimics the natural collective behavior of animals to optimize the design of electron dose distribution in EBL. The PEC algorithm is applied for pattern fabrication for U-shaped split-ring resonator and produces optimized exposure pattern that shows excellent agreement with the targeted objectives. Our work on the PEC strategy reduces the computational cost significantly and is particularly suitable for the design of complex pattern with various constraints.
Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury (2021)

In this study, pathological CT features carried different prognostic implications after mTBI to 1 year postinjury. Some patterns of injury were associated with worse outcomes than others. These results support that patients with mTBI and these CT features need TBI-specific education and systematic follow-up.
Ceria‐Catalyzed Conversion of Carbon Dioxide into Dimethyl Carbonate with 2‐Cyanopyridine (2013)

DMC run: Carbon dioxide can be converted into dimethyl carbonate in a reaction system involving 2-cyanopyridine as a dehydration agent, catalyzed by CeO2. Regeneration of the coproduct 2-picolinamide can be achieved over a Na2O/SiO2 catalyst. As a whole, the system servest to react carbon dioxide with methanol to produce dimethyl carbonate.
Study of the Mass and Spin-Parity of the Higgs Boson Candidate via Its Decays toZBoson Pairs (2013)

A study is presented of the mass and spin-parity of the new boson recently observed at the LHC at a mass near 125 GeV. An integrated luminosity of 17.3 fb(-1), collected by the CMS experiment in proton-proton collisions at center-of-mass energies of 7 and 8 TeV, is used. The measured mass in the ZZ channel, where both Z bosons decay to e or μ pairs, is 126.2 ± 0.6(stat) ± 0.2(syst) GeV. The angular distributions of the lepton pairs in this channel are sensitive to the spin-parity of the boson. Under the assumption of spin 0, the present data are consistent with the pure scalar hypothesis, while disfavoring the pure pseudoscalar hypothesis.
Multi-document summarization by visualizing topical content (2000)

This paper describes a framework for multi-document summarization which combines three premises: coherent themes can be identified reliably; highly representative themes, running across subsets of the document collection, can function as multi-document summary surrogates; and effective end-use of such themes should be facilitated by a visualization environment which clarifies the relationship between themes and documents. We present algorithms that formalize our framework, describe an implementation, and demonstrate a prototype system and interface.
GnRH agonists and the rapidly increasing use of combined androgen blockade in prostate cancer (2014)

The discovery of medical castration with GnRH agonists in 1979 rapidly replaced surgical castration and high doses of estrogens for the treatment of prostate cancer. Soon afterwards, it was discovered that androgens were made locally in the prostate from the inactive precursor DHEA of adrenal origin, a mechanism called intracrinology. Taking into account these novel facts, combined androgen blockade (CAB) using a pure antiandrogen combined with castration in order to block the two sources of androgens was first published in 1982. CAB was the first treatment shown in randomized and placebo-controlled trials to prolong life in prostate cancer, even at the metastatic stage. Most importantly, the results recently obtained with the novel pure antiandrogen enzalutamide as well as with abiraterone, an inhibitor of 17α-hydroxylase in castration-resistant prostate cancer, has revitalized the CAB concept. The effects of CAB observed on survival of heavily pretreated patients further demonstrates the importance of the androgens made locally in the prostate and are a strong motivation to apply CAB to efficiently block all sources of androgens earlier at start of treatment and, even better, before metastasis occurs. The future of research in this field thus seems to be centered on the development of more potent blockers of androgens formation and action in order to obtain better results at the metastatic stage and, for the localized stage, reduce the duration of treatment required to achieve complete apoptosis and control of prostate cancer proliferation before it reaches the metastatic or noncurable stage.
Nucleotide Sequence of the Simian‐Virus‐40 DNA Region Coding for the Carboxyl‐Terminal Part of the T Antigen (1978)

Fragment Hin d‐B‐C 2 , the second largest DNA restriction fragment generated by digestion of fragment Hin d‐B with the endo R · Eco RII enzyme, represents 4.4% of the Simian virus 40 (SV40) genome. The complete nucleotide sequence (231 base pairs) of this fragment has been determined by application of the procedure of Maxam and Gilbert (1977). This region is believed to code for the carboxyl‐terminal part of the T antigen. On the basis of the termination code words in the strand with the same polarity as the early mRNA, two open reading frames for translation could be defined. Only one of these, however, extends through the adjacent Hin d‐B‐C i fragment and is therefore believed to dictate the primary structure of the T antigen. It terminates within Hin d‐B with a TAA signal. The region, determined by the second open frame, is large enough to code for a protein of M r about 11000. The regions in SV40 DNA from which the non‐translated regions of the early and late mRNAs are transcribed overlap over nearly their entire length. Although this spacer region is very (dA + dT)‐rich, a secondary structure model can be proposed which is centered around map position 0.17. The RNA copy of the untranslated region also contains the sequence A‐A‐U‐A‐A‐A, common to all other eukaryotic mRNA molecules sequenced so far; it is present once on the late mRNA and twice on the early messenger RNA. Also a sequence of 6 or 7 successive thymidine residues is present in the early and late DNA strand respectively, 131 and 95 nucleotides beyond the polypeptide termination codons, and these may perhaps play a role in termination of transcription. Of particular interest may be the carboxyl terminus of the T antigen; the terminal tryptic peptide is 10 residues long, six of which are proline.
Visualizing Intramyocardial Steam Formation with a Radiofrequency Ablation Catheter Incorporating Near‐Field Ultrasound (2013)

Integrated US in an RF ablation catheter is able to visualize gas formation intramyocardially several seconds prior to a steam pop occurring. This technology may help prevent complications arising from steam pops.
A tunable CMOS-DRAM voltage limiter with stabilized feedback amplifier (1990)

The authors present two developments for a CMOS-DRAM voltage limiter: a precise internal-voltage generator, and a stabilized driver composed of a feedback amplifier with compensation. The voltage limiter's features include generating a PMOS-V/sub T/ difference, being capable of voltage tuning with fuse trimming, and compensation in the driver circuit through zero insertion. It provides a voltage impervious to supply-voltage and substrate-voltage boundings, temperature variation, and process fluctuation, while ensuring the feedback-loop stability with a phase margin of 55 degrees for a time-dependent load of DRAM circuit. The proposed circuits are experimentally evaluated through their implementation in a 16-Mb CMOS DRAM. A temperature dependency of 1.4 mV/ degrees C and a voltage deviation within +or-10% for process fluctuation are achieved. The voltage is stabilized within +or-3% for V/sub CC/ bounce and +or-10% for memory operation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Evaluation of the Mantle Cell Lymphoma International Prognostic Index (MIPI) as An Indicator of Overall Survival, Progression Free Survival, Survival From Relapse (2010)

Abstract Abstract 5082 Background: Prognosis for survival in mantle cell lymphoma (MCL) has recently been characterized using the MIPI algorithm. Using a retrospectively generated dataset of 150 patients with MCL seen at the H Lee Moffitt Cancer Center we sought to validate this approach in a more heterogeneous population. Methods: Patients were identified by physician survey, and through the use of our pathology and Total Cancer Care databases. Retrospective analysis was conducted with approval of our Institutional Review Board. In total 150 patients with MCL were identified, among whom MIPI data was available for 85 patients with a median followup of 36.8 months. Survival (expressed in months) was verified using our institutional records and the Social Security Death Index. Exploratory analysis of progression (n=79) and survival from the time of relapse (n=43) as stratified by MIPI were also conducted among evaluable patients. Data were compared using Kaplan-Meier survival analyses. Results: Median age was 65y (range 31–87), 73% male, 3% ECOG &gt;1, 88% stage III/IV disease, 36% with extranodal involvement, and 38% with splenomegaly. Evaluation of the entire cohort shows median OS 57 (95% CI: 48, 70.9), median PFS 21.8 (95% CI: 14.2, 25.6), and median survival after relapse 27.6 (95% CI 25.4, 30.8). No benefit in OS was observed among patients receiving Cytarabine (HR 1.04, p=0.91) and/or Rituximab (HR 1.31, p=0.61) with initial chemotherapy. Relationship between PFS and survival after relapse demonstrated rho=0.51 (p&lt;.0001). Among 85 evaluable patients 36% had elevated LDH, while 36% were MIPI-Low, 38% MIPI-Int, and 28% MIPI-High. Stratification by MIPI shows median OS of 30.4 (12.4, 42) for MIPI-High, 64.8 (53,-) for MIPI-Int, and has not been reached by MIPI-Low, with little separation between MIPI-Low and MIPI-Int groups before 60 months. PFS was 6.3 (3.7,15) for MIPI-High, 25.6 (16.5,31) for MIPI Int, and 26.5 (14,40.3) for MIPI-Low, with little separation between MIPI-Low and MIPI-Int groups before 30 months. Survival after relapse was 12.4 (9.1,25.4) for MIPI-High, 34.2 (27.6,-) for MIPI-Int, and was not reached for MIPI-Low, again with little separation between MIPI-Low and MIPI-Int groups before 30 months. Conclusions: In our experience, the MIPI remains an effective tool for stratification of OS in MCL, however, extended followup is needed to realize such differences among those with MIPI-Low and MIPI-Int disease. The MIPI was similarly effective in predicting a poor PFS and survival from relapse among those with high risk disease, though was of less utility among MIPI-Low and MIPI-Int patients. Disclosures: No relevant conflicts of interest to declare.