gebhart/patrepeval huggingface dataset:
Design and Realization of a Highly-Compact Tubular Linear Actuator for a Novel Total Artificial Heart (2023)

&lt;p&gt;The ShuttlePump is a novel implantable total artificial heart (TAH) concept based on a Linear-Rotary Actuator (LiRA) and currently under development at the Power Electronic Systems Laboratory, ETH Zurich in close partnership with Charit´e Berlin and the Medical University of Vienna.&lt;/p&gt; &lt;p&gt;This paper presents the analysis, design and realization of the ShuttlePump Linear Actuator (LA) part, which is necessary to provide about 45 N of axial actuation force. Design criteria are minimization of volume and generated power losses in the winding, which could result in excess heating and/or blood damage, i.e. protein denaturation and aggregation. The LA is implemented as a Tubular LA (TLA) to maximize the active area for linear/axial force generation. After a preliminary analysis based on first principles, the TLA is optimized in detail with the aid of FEM simulations. The experimental measurements conducted on the realized TLA prototype verify the FEM simulation results and confirm the suitability for the realization of the ShuttlePump TAH.&lt;/p&gt;
Enhanced DOA estimation algorithms using MVDR and MUSIC (2013)

This paper introduces a comparative study between two algorithms for Direction-of-Arrival (DOA) estimation which are MVDR (Minimum Variance Distortionless Response) and MUSIC (Multiple Signal classification). The used algorithms are used for Direction-of-Arrival (DOA) estimation in smart antenna. The paper presents a comparative study for both algorithms in terms of the total mobile users number, effect of signal parameters, spacing between adjacent elements, and number of snapshots. It is proven that MUSIC has better performance than MVDR algorithm. MUSIC algorithm is more effective and introduces more enhancing performance.
Iodine utilization in Li/I/sub 2/(poly-2-vinylpyridine) batteries (1980)

The Pacific salmonid species Oncorhynchus mykiss is separated into a migratory form (steelhead trout) and a non-migratory form (rainbow trout). A decrease in water temperature is likely a cue triggering downstream behavior in the migratory form, and testosterone inhibits onset of this behavior. To elucidate differences in sensitivity to water temperature decreases between the migratory and non-migratory forms and effect of testosterone on the sensitivity, we examined two experiments. In experiment 1, we compared changes in body temperature during a short-term decrease in water temperature between both live and dead steelhead and rainbow trout. In experiment 2, we investigated effects of testosterone on body temperature decrease in steelhead trout. Water temperature was decreased by 3°C in 30min. The body temperature of the steelhead decreased faster than that of the rainbow trout. In contrast, there was no significant difference in the decrease in body temperature between dead steelhead and rainbow trout specimens. The body temperature of the testosterone-treated steelhead trout decreased more slowly than that of control fish. Our results suggest that the migratory form is more sensitive to decreases in water temperature than the non-migratory form. Moreover, testosterone might play an inhibitory role in sensitivity to such decreases.
Modeling and antitumor studies of a modified L-penetratin peptide targeting E2F in lung cancer and prostate cancer (2018)

E2F1-3a overexpression due to amplification or to mutation or loss of the retinoblastoma gene, induces genes involved in DNA synthesis and leads to abnormal cellular proliferation, tumor growth, and invasion. Therefore, inhibiting the overexpression of one or more of these activating E2Fs is a recognized target in cancer therapeutics. In previous studies we identified by phage display, a novel 7-mer peptide (PEP) that bound tightly to an immobilized consensus E2F1 promoter sequence, and when conjugated to penetratin to increase its uptake into cells, was cytotoxic to several malignant cell lines and human prostate and small cell lung cancer xenografts. Based on molecular simulation studies that showed that the D-Arg penetratin peptide (D-Arg PEP) secondary structure is more stable than the L-Arg PEP, the L-Arg in the peptide was substituted with D-Arg. In vitro studies confirmed that it was more stable than the L- form and was more cytotoxic as compared to the L-Arg PEP when tested against the human castrate resistant cell line, DU145 and the human lung cancer H196 cell line. When encapsulated in PEGylated liposomes, the D-Arg-PEP potently inhibited growth of the DU145 xenograft in mice. Our findings validate D- Arg PEP, an inhibitor of E2F1and 3a transcription, as an improved second generation drug candidate for targeted molecular therapy of cancers with elevated levels of activated E2F(s).
Indirect determination of cyanide by single-column ion chromatography (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIndirect determination of cyanide by single-column ion chromatographyD. L. DuVal, J. S. Fritz, and D. T. GjerdeCite this: Anal. Chem. 1982, 54, 4, 830–832Publication Date (Print):April 1, 1982Publication History Published online1 May 2002Published inissue 1 April 1982https://pubs.acs.org/doi/10.1021/ac00241a058https://doi.org/10.1021/ac00241a058research-articleACS PublicationsRequest reuse permissionsArticle Views63Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Stereotactic Localization of Breast Lesions: How It Works and Methods to Improve Accuracy (2001)

A computer simulation of stereotactic breast biopsy was developed that paralleled the geometric configuration of a currently available breast biopsy system. This model was developed to define and improve the targeting of breast lesions with stereotactic biopsy techniques. Lesions must be clearly identified and accurately targeted on both views for successful localization. Nonvisualization of a lesion may result from overlying tissue or from the geometric configuration of the imaging system. Familiarity with the geometric configuration of the biopsy unit, especially the location of the reference point and center of rotation, facilitates understanding of apparent changes in lesion position (parallax shift). Inaccuracy in lesion targeting on one or both views will manifest predominantly as an error in the calculated z value (depth). The magnitude and direction of this error are largely determined by the direction of the targeting error. Compensatory strategies include use of a long-throw core biopsy gun or directional vacuum-assisted biopsy device and additional sampling along the z axis and should be accompanied by critical evaluation of both pre- and postfire images. Understanding geometric considerations as well as how targeting accuracy affects accuracy in lesion localization should lead to greater success in sampling even challenging breast lesions at stereotactic biopsy.
Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL (2021)

MyD88 gene mutation has been identified as one of the most prevalent driver mutations in the activated B-cell-like diffuse large B-cell lymphoma (ABC DLBCL). The published literature suggests that interleukin-1 receptor-associated kinase 1 (IRAK1) is an essential gene for ABC DLBCL harboring MyD88 mutation. Importantly, the scaffolding function of IRAK1, rather than its kinase activity, is required for tumor cell survival. Herein, we present our design, synthesis, and biological evaluation of a novel series of potent and selective IRAK1 degraders. One of the most potent compounds, <b>Degrader-3</b> (<b>JNJ-1013</b>), effectively degraded cellular IRAK1 protein with a DC<sub>50</sub> of 3 nM in HBL-1 cells. Furthermore, <b>JNJ-1013</b> potently inhibited IRAK1 downstream signaling pathways and demonstrated strong anti-proliferative effects in ABC DLBCL cells with MyD88 mutation. This work suggests that IRAK1 degraders have the potential for treating cancers that are dependent on the IRAK1 scaffolding function.
New long-range cabin mock-up enabling the simulation of flight cases my means of tempered fuselage elements (2020)

At DLR Göttingen, a new aircraft cabin mock-up is setup up allowing to simulate thermodynamically realistic boundary conditions for investigations of different ventilation concepts at ground level. Thermal manikins, individually controllable, allow the simulation of realistic heat release and obstruction of passengers. Furthermore, the manikins will be equipped with a CO2 release system simulating the exhalation of the passengers. Latest measurement techniques for velocity field measurements, high-resolution local measurement probes and tracer gas analysis complete the data acquisition system of the new test facility, facilitating the investigation of new ventilation concepts on ground level under/for different flight phases. Finally, the mock-up is designed for subject tests allowing to validate the objective measurements with human subject questionnaires.
Impact of tandem IGZO/ZnON TFT with energy-band aligned structure (2020)

Thin film transistors with high mobility and bias stability were fabricated using an In–Ga–Zn–O (IGZO)/zinc oxynitride (ZnON) tandem structure. In addition to increasing the saturation mobility from 13.44 cm2/V s to 24.75 cm2/V s, the hysteresis and device degradation under positive bias stress decreased more than five times as the ZnON semiconductor was added to the IGZO layer. These results were due to the reduced number of trapped electrons caused by the lower amount of relatively deep trap sites in the ZnON semiconductor and the existence of an energy barrier between ZnON and IGZO layers.
On a common circle: Natural scenes and Gestalt rules (2001)

To understand how the human visual system analyzes images, it is essential to know the structure of the visual environment. In particular, natural images display consistent statistical properties that distinguish them from random luminance distributions. We have studied the geometric regularities of oriented elements (edges or line segments) present in an ensemble of visual scenes, asking how much information the presence of a segment in a particular location of the visual scene carries about the presence of a second segment at different relative positions and orientations. We observed strong long-range correlations in the distribution of oriented segments that extend over the whole visual field. We further show that a very simple geometric rule, cocircularity, predicts the arrangement of segments in natural scenes, and that different geometrical arrangements show relevant differences in their scaling properties. Our results show similarities to geometric features of previous physiological and psychophysical studies. We discuss the implications of these findings for theories of early vision.
Simplification of State Transition Diagrams in Average Unavailability Analysis by Using Generalized Perturbation Theory (2014)

Safety analysis studies in nuclear engineering, more specifically system reliability, usually handle a great number of components, so that computational difficulties may arise. To face the problem of many component systems a method for simplifying the state transition diagram in Markovian reliability analyses has been proposed, using the edges which can be cut, since these latter have a smaller influence on system failure probability. In order to extend the application of GPT (Generalized Perturbation Theory), this work uses GPT formalism to reduce the number of states in a transition diagram, not considering the state probability as the integral quantity of interest, but the mean system unavailability instead. Therefore, after simplifying the original diagram, the mean unavailability for the new system was calculated and the results were very close to those of the original diagram integral quantity (giving a relative error of about 2%), showing that the proposed simplification is quite reasonable and simple to apply.
Simultaneous Acid Diversion and Water Control in Carbonate Reservoirs: ACase History From Saudi Arabia (2007)

Acid diversion and water control are usually addressed as two separate issues. Associative polymers can be used to simultaneously achieve effective diversion and water control during a single treatment. A polymer-based treatment was applied in an offshore, perforated vertical well with two sets of perforations in a carbonate reservoir in Saudi Arabia. The acid treatment was needed to restore the productivity of the upper set of perforations and reduce water production from the lower set of perforations.Experimental studies were carried out to investigate the potential use of associative polymers to control water mobility and act as an acid diverter. Coreflood experiments were conducted on reservoir cores at downhole conditions (temperature of 200°F and pressure of 3,500 psi). Extensive lab testing showed that associative polymers had no significant effect on the relative permeability to oil. However, the relative permeability to water was significantly reduced.This paper presents a case history where an associative polymer was applied during matrix acid treatment of a damaged well. The treatment included stages of associative polymer solutions and 20 wt% HCl with additives. Post stimulation treatment production data showed that oil rate increased by 11-fold; whereas water rate decreased by 3-fold; resulting in a reduction in the water-cut from 75 to 14 vol%. The PLT test confirms that the associative polymer was very effective in diverting the acid to the oil zone. The PLT showed that the upper set of perforations was producing most of the fluid, which further confirmed that the associative polymer was effective in reducing the relative permeability to water.
Oxidation behaviour of RuAl thin films: influence of diffusion barrier (2013)

Not available
Stretching of a Freely Jointed Chain in Two-Dimensions (2013)

Although the stretching of polymers and biomolecules is important in numerous settings, their response when confined to two-dimensions is relatively poorly-studied. In this paper, we derive closed-form analytical expressions for the two-dimensional force-extension response of a freely-jointed chain under force control. Our principal results relate end-to-end distance to total force under two modes of stretching: i) when force is applied only to the free of the chain, and ii) when the applied force is distributed uniformly throughout the chain. We have verified both analytical models by Brownian dynamics simulation of molecules adsorbed strongly to a substrate. The total force required is always larger if distributed throughout the chain than when it is only applied to one end of the chain, and the nature of its divergence to infinity as extension approaches contour length is different.
New Method of Minimally Invasive Removal of Megastyloids Using Intraoperative Navigation in a CT-Supported Operation Room (The Multifunctional Image-Guided Therapy Suite, MIGTS) (2005)

Introduction: The megastyloid syndrome or Eagle syndrome is a rare painful disease with dysphagia, pain while talking, and disturbances of the mouth opening caused by hypertrophic styloids. Under conventional therapy the resection of the styloids via a submandibular or retromandibular outer approach is the gold standard but causes extended outer scars. The aim in this case was to find a minimally invasive way to remove the styloids.
TREATMENT OF MULTIFOCAL SUPERFICIAL TRANSITIONAL CELL CANCER OF THE BLADDER USING ROLLER BALL ELECTROVAPORIZATION (2001)

No AccessJournal of UrologyClinical Urology: Urologists at Work1 Jan 2001TREATMENT OF MULTIFOCAL SUPERFICIAL TRANSITIONAL CELL CANCER OF THE BLADDER USING ROLLER BALL ELECTROVAPORIZATION Kurt Kerbl, and Ralph V. Clayman Kurt KerblKurt Kerbl More articles by this author , and Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1097/00005392-200101000-00034AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "TREATMENT OF MULTIFOCAL SUPERFICIAL TRANSITIONAL CELL CANCER OF THE BLADDER USING ROLLER BALL ELECTROVAPORIZATION." The Journal of Urology, 165(1), pp. 141–142 References 1 : Transurethral electrovaporization of the prostate: a novel method for treating men with benign prostatic hyperplasia. Urology1995; 45: 566. Google Scholar 2 : Transurethral vaporization of the prostate: a new technique for treatment of symptomatic BPH. J Endourol1994; 8: 145S. Google Scholar 3 : Percutaneous electrovaporization of upper tract transitional cell carcinoma in patients with functionally solitary kidneys. Urology1995; 46: 751. Google Scholar From the Department of Urology, University of Vienna, Vienna, Austria, and Division of Urologic Surgery and Department of Radiology (Mallinckrodt Institute of Radiology), Washington University School of Medicine, St. Louis, Missouri© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited ByHerr H, Donat S and Dalbagni G (2018) Correlation of Cystoscopy With Histology of Recurrent Papillary Tumors of the BladderJournal of Urology, VOL. 168, NO. 3, (978-980), Online publication date: 1-Sep-2002. Volume 165Issue 1January 2001Page: 141-142 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordsvolatilizationcarcinoma, transitional cellbladderMetricsAuthor Information Kurt Kerbl More articles by this author Ralph V. Clayman More articles by this author Expand All Advertisement PDF DownloadLoading ...
Assessing PEP and LVET from heart sounds: Algorithms and evaluation (2009)

This paper addresses the estimation of systolic time intervals, namely the pre-ejection period (PEP) and the left ventricular ejection time (LVET), using heart sound. PEP is estimated with a Bayesian approach resorting to the signal's instantaneous amplitude and typical time intervals between atrio-ventricular valve closure and aortic valve opening. As for LVET, aortic valve closure is determined through the analysis of a high-frequency signature of S2. Additionally, LVET has also been estimated from a PPG signal at a peripheral site, for the sake of comparison over a subset of data. We evaluated our algorithms on a set of 658 heartbeats and achieved 10.32 msec average absolute PEP estimation error with 7.3 msec standard deviation and for LVET, 15.8 msec average estimation error with 13.6 msec standard deviation. Current results support our assumption that heart sounds can be applied to detect the onset of the aortic valve movement processes.
Mutations in the two component regulator systems PmrAB and PhoPQ give rise to increased colistin resistance in Citrobacter and Enterobacter spp. (2020)

<b>Introduction.</b> Colistin is a last resort antibiotic for treating infections caused by carbapenem-resistant isolates. Mechanisms of resistance to colistin have been widely described in <i>Klebsiella pneumoniae</i> and <i>Escherichia coli</i> but have yet to be characterized in <i>Citrobacter</i> and <i>Enterobacter</i> species.<b>Aim.</b> To identify the causative mutations leading to generation of colistin resistance in <i>Citrobacter</i> and <i>Enterobacter</i> spp.<b>Methodology.</b> Colistin resistance was generated by culturing in increasing concentrations of colistin or by direct culture in a lethal (above MIC) concentration. Whole-genome sequencing was used to identify mutations. Fitness of resistant strains was determined by changes in growth rate, and virulence in <i>Galleria mellonella</i>.<b>Results.</b> We were able to generate colistin resistance upon exposure to sub-MIC levels of colistin, in several but not all strains of <i>Citrobacter</i> and <i>Enterobacter</i> resulting in a 16-fold increase in colistin MIC values for both species. The same individual strains also developed resistance to colistin after a single exposure at 10× MIC, with a similar increase in MIC. Genetic analysis revealed that this increased resistance was attributed to mutations in PmrB for <i>Citrobacter</i> and PhoP in <i>Enterobacter</i>, although we were not able to identify causative mutations in all strains. Colistin-resistant mutants showed little difference in growth rate, and virulence in <i>G. mellonella</i>, although there were strain-to-strain differences.<b>Conclusions.</b> Stable colistin resistance may be acquired with no loss of fitness in these species. However, only select strains were able to adapt suggesting that acquisition of colistin resistance is dependent upon individual strain characteristics.
The influence of the local oxygen vacancy concentration on the piezoresponse of strontium titanate thin films (2015)

In this study, the influence of the local oxygen vacancy concentration on piezoresponse force microscopy (PFM) measurements was investigated. Ultra-thin single-crystalline SrTiO3 thin films were deposited on niobium doped SrTiO3 substrates and analyzed using a combined PFM and local conductive atomic force microscopy (LC-AFM) measurement setup. After applying different polarization voltages between ±2 V and ±5 V to the thin films, we simultaneously observed an anomalous contrast in the piezoresponse amplitude and phase signal as well as a changed local conductivity in the exact same region. Since classic ferroelectricity can be excluded as the reason for the observed contrast, an influence of the local oxygen vacancy concentration on the piezoresponse is considered. Additionally, the surface potential was measured using Kelvin probe force microscopy (KPFM) revealing a change in surface potential in the regions of the applied voltage. The observed relaxation of the surface potential over time was fitted to a local oxidation reaction of the previously reduced regions of the ultra-thin SrTiO3 film. We propose a model that relates the local oxygen vacancy concentration to the surface potential. The influence of the oxygen vacancy concentration on the PFM measurements is explained.