gebhart/patrepeval huggingface dataset:
ChemInform Abstract: cis‐1‐Amino‐2‐indanol in Asymmetric Synthesis. Part 1. A Practical Catalyst System for the Enantioselective Borane Reduction of Aromatic Ketones. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Infrared Evanescent Absorption Spectroscopy of Toxic Chemicals Using Chalcogenide Glass Fibers (1995)

We have detected hazardous and toxic chemicals such as chlorinated hydrocarbons and benzene and its derivatives using evanescent wave spectroscopy with in‐house drawn chalcogenide glass fibers. Although, these chemicals have been readily detected down to the volume percent level, we make appropriate recommendations to lower the detection limits to the part per million level. While the current fibers can be used in lengths of up to 30 m for detection and identification of these chemicals, our results indicate that the remote capabilities of these fibers can be significantly improved into the several hundreds of meters range with lower loss fibers, as they become available with improved processing.
Detection of acute myocardial infarct with T1-mapping post ferumoxytol contrast administration (2013)

Background Gadolinium-enhanced CMR can be a useful adjunct in the diagnosis and assessment of acute myocardial infarction (AMI). However, gadolinium contrast is contraindicated in severe renal impairment. Alternative, non-gadolinium contrast agents for AMI assessment and contrast-enhanced CMR in general would be of substantial clinical importance. Ferumoxytol, an intravenous iron-supplementation drug, was approved in 2009 by the FDA for treatment of iron-deficiency anemia in patients with chronic kidney disease, and is known to have T1 shortening properties. The utility of T1-weighted ferumoxytol-enhanced CMR for detecting AMI has not been previously evaluated.
Self-Referenced Read Methodology for EMs (2018)

Mainstream memory technologies are continuing to dominate the market. 3D-NAND architectures have opened a new era for flash-based technologies allowing the prosecution of the cost reduction. DRAM technology is breaking the 20nm wall and it is near to produce 4F2 cell. This evolutionary thrust widens the space in the memory hierarchy thus allowing access to Emerging Memory (EM) technologies with performances in between NAND and DRAM. Actual access, however, depends on the level of reliability achieved by the specific EM. In particular, consistency of writing and reading mechanisms is a necessary condition for large scale production. In general, the voltage distribution of logical ones and logical zeros move with time, temperature, number of cycles, and possibly, other parameters, sometimes unknown. We propose an architectural solution applicable to a wide class of memory technologies to structurally provide a solid and reliable reading mechanism. During the reading itself, we produce, directly from the pattern stored in the cells, an adaptive reading reference able to follow these changes. Ensuring, by a proper encoding, a limited weight range for the admissible patterns, and moving the problem in the time domain, we first produce a time event to estimate the position of the lower distribution, and next, by adding an appropriate delay, a reference event to distinguish ones from zeros. Statistical simulations confirm the effectiveness of the methodology.
Americium Recovery from Highly Active PUREX Raffinate by Solvent Extraction: The EXAm Process. A Review of 10 Years of R&D (2020)

In the framework of the R&D program conducted in France on partitioning and transmutation of minor actinides, a solvent extraction process was developed for separating americium from a PUREX raffinate arising from the dissolution of spent nuclear fuels in nitric acid. The so-called EXAm process uses a mixture of a malonamide (DMDOHEMA, N,N’-dimethyl-N,N’-dioctyl-hexyloxyethyl-malonamide) and HDEHP (di-2-ethylhexylphosphoric acid) in organic phase in combination with a water-soluble complexing agent TEDGA (N,N,N’,N’-tetraethyldiglycolamide) in aqueous phase to enhance Am/Cm separation. Am/Ln separation is then obtained by selective Am stripping with polyaminocarboxylic acids (HEDTA or DTPA) buffered by citric or malonic acid at low acidity. Started in 2008, an important R&D program was conducted at CEA to optimize and model the process. The feasibility of the direct recovery of Am from a genuine PUREX raffinate by solvent extraction was demonstrated in 2010 and reported, for the first time in the literature. R&D was then conducted to adapt the process for a future scale-up and for application from concentrated PUREX raffinates. The results of the final EXAm process performed on a highly active PUREX concentrate are presented after a summary of 10 years of R&D on this process development.
In vivo activation of a microtubule-associated protein kinase during meiotic maturation of the Xenopus oocyte (1990)

International audience
Influence of Functional Groups on the Surface of Single-Walled Carbon Nanotubes as Electric Double Layer Capacitor Electrodes (2008)

Abstract not Available.
An inexpensive alternate to level-sensing automatic filling systems for liquid nitrogen (1983)

This note describes an overflow sensor used as the level controller for automatic filling systems for liquid nitrogen. It serves as an inexpensive and reliable alternative to level-sensing devices in applications where the container is to be refilled to the top at regular intervals.
Large and small signal dynamics of vertical cavity surface emitting lasers (1993)

Continuous wave relative intensity noise (RIN) measurements and pulsed electrical gain switching measurements were performed on vertical cavity surface emitting lasers in order to investigate the high speed potential of these devices. A high resonance frequency–square root of power coefficient of 7.6 GHz/√mW was obtained from the RIN measurements. The gain switched pulses exhibited very fast relaxation oscillations with a maximum observed relaxation oscillation frequency of 71 GHz.
High-Frequency Surface Acoustic Wave Resonator Filter Composed of ZnO/High-Density Electrode/Quartz Structure (2009)

In this paper, we describe the development of a radio frequency (RF) narrow-band surface acoustic wave (SAW) resonator filter composed of a ZnO/high-density metal electrode/quartz structure. First, theoretical analyses were performed to obtain a sufficient reflection coefficient and an appropriate electromechanical coupling factor, where ZnO thickness, type of electrode material, electrode thickness, and metallization ratio were used as variables. Second, one-port SAW resonators were fabricated to confirm the results of the above calculation, and a good agreement between the calculation and measurement results was obtained. Next, an RF narrow-band SAW resonator filter consisting of ZnO/Au interdigital transducer (IDT)/32° YX quartz was fabricated, and a minimum insertion loss of 2.08 dB, a -3 dB bandwidth of 3.9 MHz (0.054%), and an excellent temperature coefficient of frequency (TCF) of 4.0 ppm/°C were simultaneously achieved.
Photoresponsive hierarchical ZnO-PDMS surfaces with azobenzene-polydopamine coated nanoparticles for reversible wettability tuning (2017)

Azobenzene-bearing surfaces are promising for light-controlled wettability switching in microfluidic systems. We investigate the wettability and stability of flat glass, flat polydimethylsiloxane (PDMS) and hierarchical ZnO-PDMS surfaces functionalized with azobenzene bearing polydopamine coated nanoparticles (Azo-PDA-NP). We analyse the stability of the contact-angle switching when using new droplet locations for each measurement and for using the same droplet location with compressed-nitrogen drying between measurements. For flat glass surfaces we observed a wettability change of 15° and 60° for spin-coating and drop-casting deposition of the Azo-PDA-NP, respectively. For the PDMS samples, 60° contact-angle change are obtained, but these surfaces show degradation for repeated switching cycles. In contrast the hierarchical ZnO-PDMS surfaces exhibit a wettability switch of 50° and no degradation for five switching cycles at the same droplet location. We captured water drops during ultra-violet (UV) irradiation on video and obtained a one-sided flowing motion with a speed of 1.9 μm/s. Contact-angle hysteresis measurements show that the minimum criterion for droplet movement is fulfilled for the Azo-PDA-NP functionalized hierarchical ZnO-PDMS surfaces.
Impedance Spectra Analysis of p-Doped Organic Thin Films by Charge Carrier Distribution Evaluation (2019)

We report on a detailed study of the p-doping concentration for two hole transport materials and its influence on current voltage and impedance spectroscopy measurements. The electrical device characteristics show a large increase in current for increasing p-dopant concentration and a clear decrease in asymmetry between forward and backward bias direction. Impedance spectroscopy measurements revealed a dopant concentration dependent capacitance maximum located at zero bias voltage for both materials. With a theoretical approach we perform a quantitative description of the impedance spectroscopy measurements for all p-dopant concentrations. By fitting the measurement data, we are able to determine the doping concentration dependence of the injection barriers, the number of ionized acceptor molecules, the hole mobility, and the charge carrier distribution across the whole device. Furthermore, we are able to explain the dopant concentration dependent capacitance maximum and link it directly to the charge carrier distribution. This approach enables a microscopic interpretation of the impedance spectroscopy measurement results as well as a noninvasive analysis method to study the contact and transport properties of p-doped organic semiconductor films.
Certain cancer and RASopathy associated mutations affect Ras nanoclustering (2013)

Reference EPFL-CONF-190898View record in Web of Science Record created on 2013-12-09, modified on 2017-12-03
Nanoindentation Testing of Lithium-Ion Battery Separators (2010)

Abstract not Available.
Printing spatially-varying reflectance (2009)

Although real-world surfaces can exhibit significant variation in materials --- glossy, diffuse, metallic, etc. --- printers are usually used to reproduce color or gray-scale images. We propose a complete system that uses appropriate inks and foils to print documents with a variety of material properties. Given a set of inks with known Bidirectional Reflectance Distribution Functions (BRDFs), our system automatically finds the optimal linear combinations to approximate the BRDFs of the target documents. Novel gamut-mapping algorithms preserve the relative glossiness between different BRDFs, and halftoning is used to produce patterns to be sent to the printer. We demonstrate the effectiveness of this approach with printed samples of a number of measured spatially-varying BRDFs.
COMPUTATIONAL MODELS FOR STAGGERED BUTTED JOINTS IN LAMINATED FERROMAGNETICS (1992)

The conventional representation of a laminated packet of electrical sheet steel as a homogeneous but anisotropic material is extended by treating any butted joints in the packet as a distinct homogeneous, two‐dimensionally nonlinear, material. Its magnetic characteristics are derived from the energy increment that results from closing the gap, obtained by solving the two‐dimensional field problem in the gap region. This technique is rigorously valid for any anhysteretic, nonlinear, anisotropic material.
TLR-9 agonist and CD40-targeting vaccination induces HIV-1 envelope-specific B cells with a diversified immunoglobulin repertoire in humanized mice (2020)

The development of HIV-1 vaccines is challenged by the lack of relevant models to accurately induce human B- and T-cell responses in lymphoid organs. In humanized mice reconstituted with human hematopoietic stem cells (hu-mice), human B cell-development and function are impaired and cells fail to efficiently transition from IgM B cells to IgG B cells. Here, we found that CD40-targeted vaccination combined with CpG-B adjuvant overcomes the usual defect of human B-cell switch and maturation in hu-mice. We further dissected hu-B cell responses directed against the HIV-1 Env protein elicited by targeting Env gp140 clade C to the CD40 receptor of antigen-presenting cells. The anti-CD40.Env gp140 vaccine was injected with CpG-B in a homologous prime/boost regimen or as a boost of a NYVAC-KC pox vector encoding Env gp140 clade C. Both regimens elicited Env-specific IgG-switched memory hu-B cells at a greater magnitude in hu-mice primed with NYVAC-KC. Single-cell RNA-seq analysis showed gp140-specific hu-B cells to express polyclonal IgG1 and IgG3 isotypes and a broad Ig VH/VL repertoire, with predominant VH3 family gene usage. These cells exhibited a higher rate of somatic hypermutation than the non-specific IgG+ hu-B-cell counterpart. Both vaccine regimens induced splenic GC-like structures containing hu-B and hu-Tfh-like cells expressing PD-1 and BCL-6. We confirmed in this model that circulating ICOS+ memory hu-Tfh cells correlated with the magnitude of gp140-specific B-cell responses. Finally, the NYVAC-KC heterologous prime led to a more diverse clonal expansion of specific hu-B cells. Thus, this study shows that CD40-targeted vaccination induces human IgG production in hu-mice and provides insights for the development of a CD40-targeting vaccine to prevent HIV-1 infection in humans.
Multimodal Training Reduces Fall Frequency as Physical Activity Increases in Individuals With Parkinson’s Disease (2019)

Although SMT and MMT approaches are both effective in improving physical activity and motor symptoms of PD, only MMT reduced fall frequency after the intervention.
Phenomenology, behaviorism and psychotherapy (1973)

Abstract t “Everything begins with subjective states,” is the basic position of Phenomenology, and only through subjectivity imate reality be reached. Behaviorism, on the contrary, sees “mind” as part of the material world—the and behavior as determining man's essence (man is what he does). “Change,” which is the goal of every therapy, is attend by altering behavior which leads to changes in attitudes. The best way to alter beliefs is by controlling the behavioral cognition itself.
What Will You Do for the Rest of the Day? (2018)

Understanding and predicting human mobility is vital to a large number of applications, ranging from recommendations to safety and urban service planning. In some travel applications, the ability to accurately predict the user's future trajectory is vital for delivering high quality of service. The accurate prediction of detailed trajectories would empower location-based service providers with the ability to deliver more precise recommendations to users. Existing work on human mobility prediction has mainly focused on the prediction of the next location (or the set of locations) visited by the user, rather than on the prediction of the continuous trajectory (sequences of further locations and the corresponding arrival and departure times). Furthermore, existing approaches often return predicted locations as regions with coarse granularity rather than geographical coordinates, which limits the practicality of the prediction. In this paper, we introduce a novel trajectory prediction problem: given historical data and a user's initial trajectory in the morning, can we predict the user's full trajectory later in the day (e.g. the afternoon trajectory)? The predicted continuous trajectory includes the sequence of future locations, the stay times, and the departure times. We first conduct a comprehensive analysis about the relationship between morning trajectories and the corresponding afternoon trajectories, and found there is a positive correlation between them. Our proposed method combines similarity metrics over the extracted temporal sequences of locations to estimate similar informative segments across user trajectories. Our evaluation shows results on both labeled and geographical trajectories with a prediction error reduced by 10-35% in comparison to the baselines. This improvement has the potential to enable precise location services, raising usefulness to users to unprecedented levels. We also present empirical evaluations with Markov model and Long Short Term Memory (LSTM), a state-of-the-art Recurrent Neural Network model. Our proposed method is shown to be more effective when smaller number of samples are used and is exponentially more efficient than LSTM.
System Performance and Pre-emphasis Strategies for Submarine Links with Imperfect Gain Equalization (2020)

We studied C-band system performance penalties due to gain tilt. Several transmission pre-emphasis strategies for penalty compensation were considered. The overall penalties were small and minor differences between strategies were observed for investigated tilt range.
Evaluation of efficacy of alemtuzumab in 5 patients with aplastic anemia and/or myelodysplastic neoplasm (2016)

Patients with aplastic anemia or hypoplastic myelodysplastic syndrome (MDS) may respond to immunosuppressive therapy, including the anti-CD52 antibody alemtuzumab. We analyzed treatment responses to alemtuzumab in 5 patients with MDS or aplastic anemia (AA) evolving to MDS. Two patients with hypoplastic MDS (hMDS) showed a partial response (PR) to alemtuzumab. In both responding patients, a concomitant paroxysmal nocturnal hemoglobinuria (PNH) clone was detected before therapy. One responder relapsed after 15 months and underwent successful allogeneic stem cell transplantation. Both patients are still alive and in remission after 40 and 20 months, respectively. The other patients showed no response to alemtuzumab. One patient died from pneumonia 4 months after treatment. In summary, our data confirm that alemtuzumab is an effective treatment option for a subset of patients with MDS, even in the presence of a PNH clone.
The PREVAIL trial of enzalutamide in men with chemotherapy-naïve, metastatic castration-resistant prostate cancer: Post hoc analysis of Korean patients (2016)

In Korean patients, treatment effects and safety of enzalutamide were consistent with those observed in the overall PREVAIL study population (ClinicalTrials.gov Identifier: NCT01212991).
Measurement of distributed strain and load identification using 1500 mm gauge length FBG and optical frequency domain reflectometry (2009)

High spatial resolution and sensitivity are required in distributed strain measurements for structural health monitoring. We have developed a distributed strain sensing technique with long gauge FBG sensors, which enables to measure strain at an arbitrary position along the FBG sensors with the high spatial resolution less than 1 mm based on optical frequency domain reflectometry (OFDR). In this paper this technique with a 1500 mm gauge length FBG was applied to monitoring strain distributions of a simply supported beam subjected to bending loads. The agreement between the measured strain and the theoretical one is excellent. Also we succeeded to identify the applied load by the inverse analysis from the measured strain distribution data, and confirmed the validity of these methods.
Non-linear effects in MEMS tunable bandstop filters (2012)

This paper provides the first study of electromechanical non-linearities of MEMS tunable bandstop filters. The studied non-linearity sets a limit on the power handling capability of such filters. A two-pole MEMS tunable evanescent-mode (EVA) bandstop filter is fabricated and measured to validate the non-linear circuit modeling. Good agreement is observed between measurement and modeling. The fabricated tunable bandstop filter exhibits more than 2 W power handling capability around 2 GHz. To the authors' best knowledge this is the highest power handling reported for an L-band bandstop filter based on evanescent-mode cavity resonators.
Indeno[1,2-b]pyrazin-2,3-diones: A New Class of Antagonists at the Glycine Site of the NMDA Receptor with Potent in Vivo Activity (2000)

Indeno¿1,2-bpyrazin-2,3-diones have been identified as a novel series of potent ligands on the glycine site of the NMDA receptor. To improve their in vivo activities, an acetic acid-type side chain was introduced to the 5-position, giving water-soluble compounds when formulated as the sodium salt (>10 mg/mL). Introduction of a chlorine atom in the 8-position led to a dramatic improvement of anticonvulsant activity and this was surprising since this change did not improve binding affinity. A plausible explanation is a reduced recognition by a Na(+),K(+)-ATPase active transport system responsible for the excretion of these compounds from the brain and kidney. This promising new chemical series led to the optically active isomer (-)-10i (RPR 118723), a glycine/NMDA antagonist with nanomolar binding affinity and in vivo activity in animal model of convulsions and electrophysiology at doses in the range of 2-3 mg/kg following iv administration.
C/S-band WDM-PON employing colorless bidirectional transceivers and SOA-based broadband light sources (2005)

We present a low-cost C/S-band WDM-PON employing colorless uncooled bidirectional transceivers and SOA-based broadband light sources. Colorless operations over 32 DWDM channels are demonstrated from -20 to 80/spl deg/C in 155-Mb/s bidirectional transmissions over 25 km.
A practical algorithm for network topology inference (2006)

When a network of robots or static sensors is emplaced in an environment, the spatial relationships between the sensing units must be inferred or computed for most key applications. In this paper we present a Monte Carlo expectation maximization algorithm for recovering the connectivity information (i.e. topological map) of a network using only detection events from deployed sensors. The technique is based on stochastically reconstructing samples of plausible agent trajectories allowing for the possibility of transitions to and from sources and sinks in the environment. We demonstrate robustness to sensor error and non-trivial patterns of agent motion. The result of the algorithm is a probabilistic model of the sensor network connectivity graph and the underlying traffic trends. We conclude with results from numerical simulations and an experiment conducted with a heterogeneous sensor network
NMR Study of the Secondary Structure and Biopharmaceutical Formulation of an Active Branched Antimicrobial Peptide (2019)

The synthetic antimicrobial peptide SET-M33 is being developed as a possible new antibacterial candidate for the treatment of multi-drug resistant bacteria. SET-M33 is a branched peptide featuring higher resistance and bioavailability than its linear analogues. SET-M33 shows antimicrobial activity against different species of multi-resistant Gram-negative bacteria, including clinically isolated strains of <i>Pseudomonas aeruginosa</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumanii</i> and <i>Escherichia coli</i>. The secondary structure of this 40 amino acid peptide was investigated by NMR to fully characterize the product in the framework of preclinical studies. The possible presence of helixes or β-sheets in the structure had to be explored to predict the behavior of the branched peptide in solution, with a view to designing a formulation for parenteral administration. Since the final formulation of SET-M33 will be strictly defined in terms of counter-ions and additives, we also report the studies on a new salt form, SET-M33 chloride, that retains its activity against Gram-negative bacteria and gains in solubility, with a possible improvement in the pharmacokinetic profile. The opportunity of using a chloride counter-ion is very convenient from a process development point of view and did not increase the toxicity of the antimicrobial drug.