gebhart/patrepeval huggingface dataset:
A RIG-I 2CARD-MAVS200 Chimeric Protein Reconstitutes IFN-β Induction and Antiviral Response in Models Deficient in Type I IFN Response (2015)

RIG-I-like receptors (RLRs) are cellular sensor proteins that detect certain RNA species produced during viral infections. RLRs activate a signaling cascade that results in the production of IFN-β as well as several other cytokines with antiviral and proinflammatory activities. We explored the potential of different constructs based on RLRs to induce the IFN-β pathway and create an antiviral state in type I IFN-unresponsive models. A chimeric construct composed of RIG-I 2CARD and the first 200 amino acids of MAVS (2CARD-MAVS200) showed an enhanced ability to induce IFN-β when compared to other stimulatory constructs. Furthermore, this human chimeric construct showed a superior ability to activate IFN-β expression in cells from various species. This construct was found to overcome the restrictions of blocking IFN-β induction or signaling by a number of viral IFN-antagonist proteins. Additionally, the antiviral activity of this chimera was demonstrated in influenza virus and HBV infection mouse models using adeno-associated virus (AAV) vectors as a delivery vehicle. We propose that AAV vectors expressing 2CARD-MAVS200 chimeric protein can reconstitute IFN-β induction and recover a partial antiviral state in different models that do not respond to recombinant IFN-β treatment.
À la recherche du politique dans les villes (2020)

Cet article est une contribution à la compréhension du politique dans les sociétés contemporaines plus ou moins mondialisées envisagé à partir des villes et non de l'État, en faisant l'hypothèse que les processus d'urbanisation et de mondialisation contemporains ouvrent des possibilités de différenciation du politique et des régulations politiques à l'échelle soit transnationale soit infranationale. Cette urbanisation planétaire remet en cause à l'inverse le politique identifié à un lieu et amène à un renouvellement des questions d'inégalités, de justice, de démocratie, de citoyenneté. De manière différenciée de l'État, l'accumulation d'investissements matériels dans les villes en fait des concentrations originales de technologies qui peuvent s'analyser avec la sociologie de sciences comme des assemblages des systèmes socio-techniques où le politique se comprend en termes pragmatiques d'interactions quotidiennes.
Efficient small cell discovery mechanism exploiting network synchronization and assistance for future radio access networks (2014)

In this paper, we propose an efficient small cell discovery mechanism that addresses two problems: the increases in the UE effort and corresponding battery consumption for inter-frequency small cell discovery due to an increase in the number of frequency carriers to be measured, and the severe interference among synchronization signals (SSs) and reference signals (RSs) transmitted by clustered small cells. The proposed mechanism utilizes synchronized transmission of discovery signals (DS) for the discovery of small cells. In addition, the network informs connected UEs about the transmission timing and configuration information of DSs. Therefore, the proposed mechanism based on network synchronization and assistance can achieve fast and efficient discovery of multiple small cells, if an appropriate DS is applied. To solve the interference among synchronized DSs, the DS design based on existing SS and RS with orthogonal resource configuration is also proposed. Simulation results show that the proposed mechanism with an appropriate DS design can ensure accurate discovery of multiple small cells within a short measurement time.
The interaction of selected semiconducting biomaterials with platelet‐rich plasma and whole blood (2005)

Copper and silicon are used as biomaterials in various forms. Silicon is a well-known semiconductor and has two distinct types (n-type and p-type), depending on the dopants used. The oxides (e.g., CuO and Cu2O) on the copper surface also behave as semiconductors. The electrochemical properties of these two selected semiconducting biomaterials were investigated by cyclic voltammetry, electrochemical impedance spectroscopy (EIS), and open-circuit potential (OCP) in an aerated Ringer's solution at 37 degrees C. Platelet-rich plasma (PRP) and whole blood from a healthy human donor were used to determine the degree of interaction with the selected semiconducting materials in vitro. Morphologies of adherent platelets and blood on these two biomaterials were examined by scanning electron microscopy (SEM). Experimental results indicated that the degree of interaction is a function of the electrochemical properties of these two biomaterials. Platelets and blood were found to react strongly with p-type biomaterials while little or no sign of interaction with n-type biomaterials was demonstrated. The difference in PRP and whole blood reactions between p-type and n-type semiconductors was quantified to be significant as p<0.05.
Figure S2 from Cabozantinib Reverses Renal Cell Carcinoma–mediated Osteoblast Inhibition in Three-dimensional Coculture <i>In Vitro</i> and Reduces Bone Osteolysis <i>In Vivo</i> (2023)

&lt;p&gt;ALP and OSC gene expression in human Bo-786 RCC cells and PC3 prostate cancer cells&lt;/p&gt;
Cognito: Automated Feature Engineering for Supervised Learning (2016)

Feature engineering involves constructing novel features from given data with the goal of improving predictive learning performance. Feature engineering is predominantly a human-intensive and time consuming step that is central to the data science workflow. In this paper, we present a novel system called "Cognito", that performs automatic feature engineering on a given dataset for supervised learning. The system explores various feature construction choices in a hierarchical and non-exhaustive manner, while progressively maximizing the accuracy of the model through a greedy exploration strategy. Additionally, the system allows users to specify domain or data specific choices to prioritize the exploration. Cognito is capable of handling large datasets through sampling and built-in parallelism, and integrates well with a state-of-the-art model selection strategy. We present the design and operation of Cognito, along with experimental results on eight real datasets to demonstrate its efficacy.
Commercialization of Ultra-Hard Ceramics for Cutting Tools Final Report CRADA No. TC0279.0 (2017)

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Greenleaf Corporation (Greenleaf) to develop the technology for forming unique precursor nano-powders process that can be consolidated into ceramic products for industry. LLNL researchers have developed a solgel process for forming nano-ceramic powders. The nano powders are highly tailorable, allowing the explicit design of desired properties that lead to ultra hard materials with fine grain size. The present CRADA would allow the two parties to continue the development of the sol-gel process and the consolidation process in order to develop an industrially sound process for the manufacture of these ultra-hard materials.
Reduced-noise nonreciprocal transducer based upon vacuum tunneling (1989)

Displacement sensors that work by taking advantage of the nonlinear displacement-current relationship of an electron vacuum-tunneling probe (VTP) are theoretically analyzed in this paper. We show, using the language of electromechanical two-port transducers, that the VTP is nonreciprocal and that its noise is intrinsically quantum limited. We present a semiquantitative analysis of a VTP used to monitor the displacement of a simple mechanical harmonic oscillator and show that the Heisenberg uncertainty relation for the position and momentum of the mechanical oscillator is enforced by the noise in the VTP. The results of an optimal filter calculation of the sensitivity of the VTP-mechanical oscillator system for impulsive force detection are presented. These results are contrasted with results for a conventional capacitive transducer, and we show that the VTP may offer vastly increased sensitivity as a consequence of its nonreciprocity. The maximum sensitivity of the VTP system is calculated as a function of the temperature, the dc tunneling current, and the mass, frequency, and quality factor of the mechanical oscillator. For typical operating conditions the maximum sensitivity is obtained for small-mass systems, which makes the VTP ideal for miniature accelerometers and related devices.
Reference models, window systems, and concurrency (1987)

article Reference models, window systems, and concurrency Share on Authors: K A Lantz View Profile , P P Tanner View Profile , C Binding View Profile , Kuan-Tsae Huang View Profile , A Dwelly View Profile Authors Info & Claims ACM SIGGRAPH Computer GraphicsVolume 21Issue 2April 1987 pp 87–97https://doi.org/10.1145/24919.24922Online:01 April 1987Publication History 22citation225DownloadsMetricsTotal Citations22Total Downloads225Last 12 Months3Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Decoding Energy Modeling For Versatile Video Coding (2020)

In previous research, it was shown that the software decoding energy demand of High Efficiency Video Coding (HEVC) can be reduced by 15% by using a decoding-energy-ratedistortion optimization algorithm. To achieve this, the energy demand of the decoder has to be modeled by a bit stream feature-based model with sufficiently high accuracy. Therefore, we propose two bit stream feature-based models for the upcoming Versatile Video Coding (VVC) standard. The newly introduced models are compared with models from literature, which are used for HEVC. An evaluation of the proposed models reveals that the mean estimation error is similar to the results of the literature and yields an estimation error of 1.85% with 10-fold cross-validation.
Toward Prediction of Magnetic Properties in Layered Vanadyl Phosphonates:  Correlation of Magnetic Exchange with the Hammett σ Parameter (1997)

The magnetic properties of the layered vanadyl phosphonates (LVPs) VO(O3PC6H4−X)·nH2O (X = p-NO2, m-F, p-Cl, p-F, H, p-CH3) have been investigated. In the isostructural n = 1 series (X = p-NO2, m-F, p-F, H), the paramagnetic d1 vanadyl centers are coupled via the O−P−O pathways of V(OPO)2V chair-like subunits. The magnetic properties of these LVPs can be systematically controlled by modification of the P atom's electronic environment via variations of the X group in the aryl pendant. The simple paramagnetism of the LVP featuring the strong electron withdrawing substituent X = p-NO2 gives way to increasing antiferromagnetic coupling between the VIV centers as the electron-donating ability of X is increased. Consistent with a chair-like V(OPO)2V exchange pathway between pairs of vanadyl centers, the temperature-dependent magnetic susceptibility data fit a Bleaney−Bowers dimer model. When the substituent is large, as is the case for the p-Cl and p-CH3 species, a structurally different class of LVPs is obtained, in which n = 1.5. In this case, the contribution of the O−P−O linkage is overwhelmed by the presence of the more direct exchange pathway of vanadyl centers through μ2-bridging oxygens of a V(μ2-O)2V dimer, obviating the effects of electronic variations in the phosphonate bridge. Our results show that magnetic coupling correlates with a simple measure of electronic perturbation of the exchange pathway in LVPs, implying that such interactions can be tuned using the traditional tools of physical organic chemistry.
CPW-fed cusp antenna (1999)

In this letter, a new design for a planar antenna is introduced. The antenna is built using coplanar technology. It has dual-frequency operation: the first and second resonances are in the X- and Ku-bands, respectively. The proposed antenna has wideband behavior around both resonance frequencies. It has a dipole-like radiation pattern, which makes it suitable for phased-array applications. The analysis is carried out both theoretically and experimentally, and very good agreement is observed. The results include the return loss, the current distribution, the radiation patterns, and the antenna gain. ©1999 John Wiley & Sons, Inc. Microwave Opt Technol Lett 22: 288–290, 1999.
Quantifying the effects of recent protocol improvements to standards-track TCP (2004)

We assess the state-of-the-art in Internet congestion control and error recovery through a controlled study that considers the integration of standards-track TCP error recovery and both TCP and router-based congestion control. The goal is to examine and quantify the benefits of deploying standards-track technologies for Internet traffic as a function of the level of offered network load. We limit our study to the dominant and most stressful class of Internet traffic: bursty HTTP flows. Contrary to expectations and published prior work, we find that for HTTP flows (1) there is no clear benefit in using TCP SACK over TCP Reno, (2) unless congestion is a serious concern (i.e., unless average link utilization is above approximately 80%), there is little benefit to using Adaptive RED queue management, (3) above 80% link utilization there is potential benefit to using Adaptive RED with ECN marking, however, complex performance trade-offs exist and results are sensitive to parameter settings.
Monitoring the Antitumor Response of Naive and Memory CD8 T Cells in RAG1−/− Mice by Positron-Emission Tomography (2006)

Therapeutic antitumor immunity depends on a highly migratory CTL population capable of activation and trafficking between lymphoid and tumor-bearing microanatomic sites. We recently adapted positron-emission tomography gene expression imaging for noninvasive, longitudinal localization and quantitation of antitumor T lymphocyte migration in vivo. In this study, we apply this system to enumerate the temporal accumulation of naive vs memory T cells. Naive or memory OT-1 CD8(+) T cells, retrovirally marked with the sr39TK gene, were adoptively transferred into RAG1(-/-) animals bearing EL-4 or EG.7 (an OVA-expressing subline), and repetitively imaged by microPET over several weeks. Memory cells demonstrated early accumulation and apparent proliferation, with large T cell numbers at the Ag-positive tumor as early as day 1 after T cell transfer. Naive T cells did not accumulate in the E.G7 tumor until day 8, and reached only 25% of the peak levels achieved by memory T cells. Both naive and memory cells eradicated the Ag-expressing tumor at a comparable density of intratumoral T cells (2-4 x 10(6)/g). However, due to the slower rate of T cell expansion and continued tumor growth, naive cells required approximately 10-fold higher Ag-specific precursor frequency to reach a tumoricidal cell density. As recently reported, memory but not naive T cells accumulated in local lymph nodes and lungs, where they persisted as a resident population after tumor eradication. Positron-emission tomography-based immunologic imaging is a noninvasive modality providing unique and meaningful information on the dynamics of the antitumor CTL response.
Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis (2022)

Aged and photoaged skin exhibit fine wrinkles that are signs of epidermal inflammation and degeneration. It has been shown that healthy elderly skin expresses amyloidogenic proteins, including α-Synuclein, which are known to oligomerize and trigger inflammation and neurodegeneration. However, little is known about their putative role in skin physiology and sensitivity. To unravel this possible role, we investigated the impact of oligomeric α-Synuclein (Oα-Syn) in 2D and 3D keratinocyte human models. Exogenous Oα-Syn caused degeneration of reconstructed human epidermis (RHE) by diminishing proliferation and thickness of the stratum basale. Oα-Syn also increased NF-kB nuclear translocation in keratinocytes and triggered inflammation in the RHE, by increasing expression of interleukin-1β and tumor necrosis factor-alpha, and the release of tumor necrosis factor-alpha in a time-dependent manner. Dexamethasone and an IL-1β inhibitor partially diminished RHE degeneration caused by Oα-Syn. These findings suggest that Oα-Syn induces epidermal inflammation and decreases keratinocyte proliferation, and therefore might contribute to epidermal degeneration observed in human skin aging.
Bilateral Vibrotactile Feedback for Accurate Lateralization in Hearing Instrument Body Area Networks (2011)

Hearing Instruments (HIs) have emerged as true body area networks (HI-BANs). They connect wirelessly to accessories such as remote controls and Bluetooth devices. Multimodal sensor data from a HI-BAN is a way to adapt the HI behavior to the user's current hearing situation. As a potential future HI-
Pulicaria undulata Extract-Mediated Eco-Friendly Preparation of TiO2 Nanoparticles for Photocatalytic Degradation of Methylene Blue and Methyl Orange (2022)

Eco-friendly approaches for the preparation of nanomaterials have recently attracted considerable attention of scientific community due to rising environmental distresses. The aim of the current study is to prepare titanium dioxide (TiO<sub>2</sub>) nanoparticles (NPs) using an eco-friendly approach and investigate their performance for the photocatalytic degradation of hazardous organic dyes. For this, TiO<sub>2</sub> NPs were prepared by using the aqueous extract of the <i>Pulicaria undulata</i> (L.) plant in a single step at room temperature. Energy-dispersive X-ray spectroscopy established the presence of both titanium and oxygen in the sample. X-ray diffraction revealed the formation of crystalline, anatase-phase TiO<sub>2</sub> NPs. On the other hand, transmission election microscopy confirmed the formation of spherical shaped NPs. The presence of residual phytomolecules as capping/stabilization agents is confirmed by UV-vis analysis and Fourier-transform Infrared spectroscopy. Indeed, in the presence of <i>P. undulata</i>, the anatase phase of TiO<sub>2</sub> is stabilized at a significantly lower temperature (100 °C) without using any external stabilizing agent. The green synthesized TiO<sub>2</sub> NPs were used to investigate their potential for the photocatalytic degradation of hazardous organic dyes including methylene blue and methyl orange under UV-visible light irradiation. Due to the small size and high dispersion of NPs, almost complete degradation (∼95%) was achieved in a short period of time (between 1 and 2 h). No significant difference in the photocatalytic activity of the TiO<sub>2</sub> NPs was observed even after repeated use (three times) of the photocatalyst. Overall, the green synthesized TiO<sub>2</sub> NPs exhibited considerable potential for fast and eco-friendly removal of harmful organic dyes.
5C-2 Non-Invasive Ultrasound Elastic Modulus Estimates on Tissue Scaffold Mechanical Property Change (2007)

Tissue engineers are greatly interested in non- invasively evaluating the extent of cell growth, scaffold degradation, and tissue development both in vitro and in vivo as a function of time. Current evaluation methods such as cell histology and direct mechanical measurements can only provide static snapshots using different specimens at different time points. These measurements introduce specimen to specimen and animal to animal variation. MRI and CT can monitor scaffold degradation and tissue growth in the same specimen over time, but provide only morphological information. Ultrasound Elasticity Imaging based on phase sensitive speckle tracking can characterize the internal structural and compositional change at a high resolution of a few hundreds of microns. In this study, ultrasound elasticity imaging was applied to poly (1, 8 octanediol-co-citrate) (POC) scaffold embedded in a gelatin phantom at different stages of chemically induced degradation and compared with direct mechanical measurements. Although ultrasound strain imaging measures the mechanical property change of the scaffold as degradation progresses, further investigation on absolute elastic modulus estimate is needed. Novel elastic modulus reconstruction algorithm was applied to the displacement estimates from speckle tracking. The reconstructed elastic modulus compared well with direct mechanical measurements.
ChemInform Abstract: One‐Pot Catalytic Enantioselective Domino Nitro‐Michael/Michael Synthesis of Cyclopentanes with Four Stereocenters. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An a priori knee identification multi-objective evolutionary algorithm based on α -dominance (2019)

In the preference-based multi-objective optimization, the lack of priori-knowledge makes it difficult for the decision maker to specify an informed preference. Thus, the knees are regarded as the naturally preferred solutions on the Pareto optimal front. However, most research is based on a given large number of solutions and a posteriori identifies the knee candidates among them.
An Interactive Warping Method for Multi-channel VR Projection Display Systems with Quadric Surface Screens (2013)

In this paper, we present a practical non-camera-based interactive warping method for multi-channel immersive VR projection display systems with quadric surface screens. Instead of using one or multiple cameras as most previous methods did, we employ a commercial theodolite and a mouse to interactively calibrate each projector on site. By taking advantage of the nature of shape of the curved screen, we are able to perform fast, robust projector calibration and compute the warping map for each projector by taking other system information into account, i.e., position/frustum of the designed eye point (DEP). Compared with camera-based solutions, our method is accurate, cost-effective, simple to operate, and can reduce system set-up time and complexity efficiently. The feasibility of our method has been verified by many real site installations.
Additive and synergistic effects of a novel antiestrogen, toremifene (Fc-1157a), and human interferons on estrogen responsive MCF-7 cells in vitro. (1985)

The effect of human interferons alpha and gamma alone and in combination with a novel antiestrogen toremifene were studied in vitro using MCF-7 cell line, an estrogen receptor positive and antiestrogen sensitive cell line. The effects were evaluated by a simple bioluminescence method with which the number of living cells was obtained as cellular adenosine triphosphate (ATP) content. The growth of MCF-7 cells was inhibited both by interferon alpha and interferon gamma. At least additive effect was evident when the cells were exposed to combination of interferons and toremifene: the combination was additive with interferon gamma + toremifene and synergistic with interferon alpha + toremifene. The combination of toremifene and interferons may have clinical importance.