gebhart/patrepeval huggingface dataset:
DC flashover characteristics of a polymeric insulator in presence of surface charges (2012)

Effect of surface charges on dc flashover characteristics of a composite polymeric insulator is studied by means of experiments and theoretical calculations. The considered insulator consisted of a glass fiber reinforced epoxy core covered with a layer of silicone rubber and terminated by metallic electrodes with rounded smooth edges. In the experiments, the insulator surface was charged by external corona while keeping the electrodes grounded and different charging levels were realized by varying its intensity. A series of disruptive discharge tests were carried out on the charged insulator under negative dc voltages. It was revealed that negative deposited surface charges led to an enhancement of the flashover performance whereas positive ones reduced the flashover voltage level. A theoretical model has been developed and utilized for analyzing the experimental results. In the model, surface charge density profiles deduced from measured surface potential distributions were used as boundary conditions for calculations of electric fields. The measured and calculated flashover voltages were found to be in agreement indicating that the observed variations in the flashover characteristics could be attributed to the modifications of the electric field produced by the surface charges.
In VitroandIn VivoEvaluation of Carboplatin Delivery to the Eye Using Hydrogel-Iontophoresis (2008)

Carboplatin-iontophoretic application at the above conditions does not have an obvious advantage over passive penetration due to high diffusion properties and insufficient molecular charge. Passive carboplatin diffusion from loaded hydrogels inserted in the lower cul-de-sac should be further investigated as a potential clinical treatment for intraocular retinoblastoma.
Mechanism of agonist and antagonist binding to .alpha.2 adrenergic receptors: evidence for a precoupled receptor-guanine nucleotide protein complex (1988)

The alpha 2 adrenergic receptor (AR) inhibits adenylate cyclase via an interaction with Ni, a guanine nucleotide binding protein. The early steps involved in the activation of the alpha 2 AR by agonists and the subsequent interaction with Ni are poorly understood. In order to better characterize these processes, we have studied the kinetics of ligand binding to the alpha 2 AR in human platelet membranes on the second time scale. Binding of the alpha 2 antagonist [3H]yohimbine was formally consistent with a simple bimolecular reaction mechanism with an association rate constant of 2.5 X 10(5) M-1 s-1 and a dissociation rate constant of 1.11 X 10(-3) s-1. The low association rate constant suggests that this is not a diffusion-limited reaction. Equilibrium binding of the alpha 2 adrenergic full agonist [3H]UK 14,304 was characterized by two binding affinities: Kd1 = 0.3-0.6 nM and Kd2 = 10 nM. The high-affinity binding corresponds to approximately 65% and the low-affinity binding to 35% of the total binding. The kinetics of binding of [3H]UK 14,304 were complex and not consistent with a mass action interaction at one or more independent binding sites. The dependence of the kinetics on [3H]UK 14,304 concentration revealed a fast phase with an apparent bimolecular reaction constant kappa + of 5 X 10(6) M-1 s-1. The rate constants and amplitudes of the slow phase of agonist binding were relatively independent of ligand concentration. These results were analyzed quantitatively according to several variants of the "ternary complex" binding mechanism. In the model which best accounted for the data, (1) approximately one-third of the alpha 2 adrenergic receptor binds agonist with low affinity and is unable to couple with a guanine nucleotide binding protein (N protein), (2) approximately one-third is coupled to the N protein prior to agonist binding, and (3) the remainder interacts by a diffusional coupling of the alpha 2 AR with the N protein or a slow, ligand-independent conformational change of the alpha 2 AR-N protein complex. The rates of interaction of liganded and unliganded receptor with N protein are estimated.
Supplementary Legends 1-3 from Cytochrome <i>P</i>450 Epoxygenase Promotes Human Cancer Metastasis (2023)

Supplementary Legends 1-3 from Cytochrome &lt;i&gt;P&lt;/i&gt;450 Epoxygenase Promotes Human Cancer Metastasis
Structural Characterization of Quinoxaline Homopolymers and Quinoxaline/Ether Sulfone Copolymers by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (2001)

Polyphenylquinoxalines (PPQs) are prepared from self-polymerizable quinoxaline monomers that carry fluorine, hydroxyaryl (ArOH), and phenyl substituents. In basic media, these monomers self-polymerize via a series of nucleophilic aromatic substitution reactions (SNAr), in which aromatic enolates (ArO- nucleophiles) attack the electrophilic carbons bearing F leaving groups to effect fluoride displacement. Polyphenylquinoxaline/polyether-sulfone (PPQ/PES) copolymers are synthesized similarly by combining self-polymerizable quinoxaline monomers with a 1:1 molar mixture of 4,4'-dichlorodiphenyl sulfone and bisphenol A. The MALDI mass spectra of the polymers reveal that the major products up to approximately 15,000 Da molecular mass are homo- or copolymeric macrocycles. Linear byproducts are also observed, arising from nucleophilic ring opening of already formed macrocycles. Oligomers containing at least one PPQ unit readily protonate upon MALDI, whereas PES homopolymers require alkali metal ion addition to become detectable. Molecular orbital calculations point out that the nucleophilic and electrophilic reactivities of the PPQ monomer and the PPQ growing chains generated during propagation are comparable, allowing for continued condensations via SN-Ar, until cyclization terminates this process. The calculations also predict a significantly lower electrophilic reactivity for carbons substituted by chlorine instead of fluorine, justifying the discrimination against incorporation of PES units observed for the copolymers. The computationally optimized structures of PPQ and PPQ/PES macrocycles show a diverse array of cavity sizes and geometries which depend on the size of the macrocycle, the sequence of the repeat units, and the position of the substituents in the quinoxaline ring; quinoxaline pendants (phenyl groups) are found to favor helical arrangements in the prepared macrocycles.
Functional mapping of the human cerebellum with positron emission tomography. (1985)

Alterations of local neuronal activity induced within the human cerebellum by tactile stimulation and voluntary movement were mapped with positron emission tomographic measurements of brain blood flow. Finger movements produced bilateral, parasagittal blood-flow increases in anterior, superior hemispheric cortex of the cerebellum. Responses to tactile finger stimulation were coextensive with responses to voluntary finger movements but were less intense. Saccadic eye movements produced midline blood-flow increases in the posterior vermis of the cerebellum. Positron emission tomography now permits investigation of functional-anatomical relations within the human cerebellum.
Communion and the Trinity: distinct relations with Father, Son and Spirit (2018)

Communion with the triune God is necessarily Trinitarian. But does that simply mean that all three divine persons are involved, or is there a case for the Christian communing distinctly with each person? This thesis argues for the latter. Distinct communion has not flourished within western Christianity, although the Puritan, John Owen, breaks the mould. In order to arrive at the concept, two preliminary steps must be taken. First, the range of New Testament terminology for communion with God must be appreciated; only then will the authors’ devotional Trinitarianism become properly visible. Secondly, the triune God must be viewed through the lenses of the redemptive storyline; only then will the Three be recognised in their full distinctness, and a theological framework established within which tri-personal communion makes sense. 
In this thesis these two areas are foregrounded, but other, related matters are also addressed. Not all biblical communion distinguishes between the three persons. Then there is the person of the Spirit, the direct worship of whom may appear problematic. There are also more ‘practical’ issues associated with (especially public, liturgical) distinct communion: for instance, the advisability of shifting focus within a single prayer from one divine person to another.
John Owen rightly recognised the importance of distinct communion. The doctrine of the Trinity is not dry and irrelevant, a theme only fit for academic speculation. It is the central truth of biblical religion, and must, therefore, be appropriated at the level of ordinary Christian piety.
Angiogenic Responses of Vascular Endothelial Growth Factors in Periadventitial Tissue (2003)

Recent discovery of new members of the vascular endothelial growth factor (VEGF) family has generated much interest as to which members may be best suited for therapeutic angiogenesis in various tissues. In this study we evaluated angiogenic responses of the different members of the VEGF family in vivo using adenoviral gene transfer. Adenoviruses (1 x 10(9) plaque-forming units [pfu]) encoding for VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-C(deltaNdeltaC) and VEGF-D(deltaNdeltaC) (deltaNdeltaC are proteolytically cleaved forms) were transferred locally to the periadventitial space of the rabbit carotid arteries using a collar technique that allows efficient local transfection of the periadventitial tissue. Expression of the transfected VEGFs was confirmed by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). Seven days after the gene transfer maximum neovessel formation was observed in VEGF-A-, VEGF-D-, and VEGF-D(deltaNdeltaC)-transfected arteries. VEGF-C(deltaNdeltaC) also showed angiogenic activity whereas VEGF-B was not effective in inducing angiogenesis. Pericytes were detected around the neovessels, which also frequently showed the presence of intraluminal erythrocytes. Infiltration of inflammatory cells in response to VEGF-D and VEGF-D(deltaNdeltaC) was less prominent than that caused by other VEGFs. In line with the absence of lymphatics in the normal carotid arteries no significant evidence of lymphatic vessel formation was seen in response to any of the studied VEGFs in the periadventitial space. The results help to define possibilities for local angiogenic therapy around blood vessels and support the concept that angiogenic effects may be tissue-specific and depend both on the growth factor ligands and the target tissues. It is concluded that VEGF-A, VEGF-D, and VEGF-D(deltaNdeltaC) are the best candidates for therapeutic angiogenesis when delivered around large arteries.
Memristor-Based HTM Spatial Pooler With On-Device Learning for Pattern Recognition (2020)

This article investigates hardware implementation of hierarchical temporal memory (HTM), a brain-inspired machine learning algorithm that mimics the key functions of the neocortex and is applicable to many machine learning tasks. Spatial pooler (SP) is one of the main parts of HTM, designed to learn the spatial information and obtain the sparse distributed representations (SDRs) of input patterns. The other part is temporal memory (TM) which aims to learn the temporal information of inputs. The memristor, which is an appropriate synapse emulator for neuromorphic systems, can be used as the synapse in SP and TM circuits. In this article, a memristor-based SP (MSP) circuit structure is designed to accelerate the execution of the SP algorithm. The presented MSP has properties of modeling both the synaptic permanence and the synaptic connection state within a single synapse, and on-device and parallel learning. Simulation results of statistic metrics and classification tasks on several real-world datasets substantiate the validity of MSP.
PNS Estimation of a High Performance Head Gradient Coil by a Coupled Electromagnetic Neurodynamic Simulation Method (2021)

With the recent advancement in high-performance head gradient coil technology for magnetic resonance imaging, the assessment of peripheral nerve stimulation (PNS) has become increasingly important. In this paper we employed a coupled electromagnetic neurodynamic simulation to estimate the PNS level in a human body model for a high gradient amplitude and high slew rate head gradient coil. The results show strong correlation between simulations and measurements.
Bulky iodotriazolium tetrafluoroborates as highly active halogen-bonding-donor catalysts (2018)

Steric bulk around catalytic centers is one of the most important factors determining catalytic reactivities and selectivities. This paper reports the synthesis of structurally diverse 5-iodo-3-methyl-1,2,3-triazolium salts and the evaluation of their catalytic activities as halogen-bonding donors for the aza-Diels-Alder reaction of 2-siloxy-1,3-butadiene with imines. We found that steric hindrance around an iodide atom in halogen-bonding donors significantly impacted catalytic efficiency.
BENZYLLITHIUM: PREPARATION, REACTIONS AND X-RAY CRYSTAL STRUCTURE OF BENZYLLITHIUM·2THF (1998)

Benzyllithium can be prepared in relatively high concentrations in mixtures of cyclic ethers via metalation of toluene with n-or sec-butyllithium. The solubility and stability increases markedly, in mixtures of cyclic ethers, overTHF alone. In THF/toluene, benzyllithium crystallizes out as a linear polymer with alternating C's and Li's making up the polymer backbone with each lithium solvated by 2 THF's.
Polaron coupling constants in BaSnO$_3$ (2016)

The transverse and longitudinal optical phonon modes in BaSnO$_3$ are re-evaluated from the previously reported far-infrared ellipsometry spectra of single crystals. These are employed to determine polaron coupling constants, which provide the basis for theoretical calculations of the room temperature electron mobility in BaSnO$_3$. The relaxation time for the longitudinal optical phonon scattering in BaSnO$_3$ is larger as compared to SrTiO$_3$, contributing to the high room temperature electron mobility reported for the La-doped BaSnO$_3$ single crystals.
Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis (2023)

Many epithelial compartments undergo constitutive renewal in homeostasis but activate unique regenerative responses following injury. The clear corneal epithelium is crucial for vision and is renewed from limbal stem cells (LSCs). Using single-cell RNA sequencing, we profiled the mouse corneal epithelium in homeostasis, aging, diabetes, and dry eye disease (DED), where tear deficiency predisposes the cornea to recurrent injury. In homeostasis, we capture the transcriptional states that accomplish continuous tissue turnover. We leverage our dataset to identify candidate genes and gene networks that characterize key stages across homeostatic renewal, including markers for LSCs. In aging and diabetes, there were only mild changes with <15 dysregulated genes. The constitutive cell types that accomplish homeostatic renewal were conserved in DED but were associated with activation of cell states that comprise "adaptive regeneration." We provide global markers that distinguish cell types in homeostatic renewal vs. adaptive regeneration and markers that specifically define DED-elicited proliferating and differentiating cell types. We validate that expression of SPARC, a marker of adaptive regeneration, is also induced in corneal epithelial wound healing and accelerates wound closure in a corneal epithelial cell scratch assay. Finally, we propose a classification system for LSC markers based on their expression fidelity in homeostasis and disease. This transcriptional dissection uncovers the dramatically altered transcriptional landscape of the corneal epithelium in DED, providing a framework and atlas for future study of these ocular surface stem cells in health and disease.
A novel three-phase utility interface minimizing line current harmonics of high-power telecommunications rectifier modules (2002)

Based on the combination of a three-phase diode bridge and DC/DC boost converter a new three-phase three-switch three-level PWM rectifier system is developed. It can be characterized by sinusoidal mains current consumption, controlled output voltage and low blocking voltage stress on the power transistors. The application could be, e.g., for feeding the DC link of a telecommunications power supply module. The stationary operational behavior, the control of the mains currents and of the output voltage are analyzed. Finally, the stresses on the system components are determined by digital simulation and compared to the stresses in a conventional PWM rectifier system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
MACHETE: Environment for Space Networking Evaluation (2010)

Space Exploration missions requires the design and implementation of space networking that differs from terrestrial networks. In a space networking architecture, interplanetary communication protocols need to be designed, validated and evaluated carefully to support different mission requirements. As actual systems are expensive to build, it is essential to have a low cost method to validate and verify mission/system designs and operations. This can be accomplished through simulation. Simulation can aid design decisions where alternative solutions are being considered, support trade-studies and enable fast study of what-if scenarios. It can be used to identify risks, verify system performance against requirements, and as an initial test environment as one moves towards emulation and actual hardware implementation of the systems. We describe the development of Multi-mission Advanced Communications Hybrid Environment for Test and Evaluation (MACHETE) and its use cases in supporting architecture trade studies, protocol performance and its role in hybrid simulation/emulation. The MACHETE environment contains various tools and interfaces such that users may select the set of tools tailored for the specific simulation end goal. The use cases illustrate tool combinations for simulating space networking in different mission scenarios. This simulation environment is useful in supporting space networking design for planned and future missions as well as evaluating performance of existing networks where non-determinism exist in data traffic and/or link conditions.
Glycine Receptors and Glycinergic Synaptic Input at the Axon Terminals of Mammalian Retinal Rod Bipolar Cells (2003)

We investigated the properties of glycine receptors and glycinergic synaptic inputs at the axon terminals of rod bipolar cells (RBCs) in rats by patch-clamp recording. Glycine currents recorded from isolated axon terminals were larger than those from isolated somata/dendrites; this was confirmed by puffing glycine onto these two regions in retinal slices. The current density at terminal endings was more than one order of magnitude higher than the density at somatic/dendritic regions. Glycine currents from isolated terminals and isolated somata/dendrites showed similar sensitivity to picrotoxinin blockade. Single-channel opening recorded from isolated terminals and somata/dendrites displayed a similar main-state conductance of ~46 pS. Application of glycine effectively suppressed depolarization-evoked increases in intracellular Ca2+ at the terminals. In the presence of GABAA and GABAC antagonists, strychnine-sensitive chloride currents were evoked in RBCs in retinal slices by puffing kainate onto the inner plexiform layer. No such currents were observed if the recorded RBCs did not retain axon terminals or if Ca2+ was replaced by Co2+ in the extracellular solution. The currents displayed discrete miniature-like events, which were partially blocked by tetrodotoxin. Consistent with early studies in the rabbit and mouse, this study demonstrates that glycine receptors are highly concentrated at the axon terminals of rat RBCs. The pharmacological and physiological properties of glycine receptors located in the axon terminal and somatic/dendritic regions, however, appear to be the same. This study provides evidence for the existence of functional glycinergic synaptic input at the axon terminals of RBCs, suggesting that glycine receptors may play a role in modulating bipolar cell synaptic transmission.
SWIPT Signalling over Complex AWGN Channels with Two Nonlinear Energy Harvester Models (2018)

Simultaneous Wireless Information and Power Transfer (SWIPT) is subject to nonlinearity at the energy harvester that leads to significant changes to transmit signal designs compared to conventional wireless communications. In this paper, the capacity of a discrete time, memoryless and complex Additive White Gaussian Noise (AWGN) channel in the presence of a nonlinear energy harvester at the receiver is studied. Considering the two common nonlinear energy harvester models introduced in the literature, two sets of constraints are considered. First the capacity is studied under average power (AP), peak amplitude (PA) and receiver delivery power (RDP) constraints. The RDP constraint is modelled as a linear combination of even-moment statistics of the channel input being larger than a threshold. It is shown that the capacity of an AWGN channel under AP and RDP constraints is the same as the capacity of an AWGN channel under an AP constraint, however, depending on the two constraints, it can be either achieved or arbitrarily approached. It is also shown that under AP, PA and RDP constraints, the amplitude of the optimal inputs is discrete with a finite number of mass points. Next, the capacity is studied under AP, PA and output outage probability (OOP) constraints. OOP is modelled as satisfying a certain probability inequality for the amplitude of the received signal being outside of a given interval. Similarly, it is shown that the amplitude of the optimal input is discrete with a finite number of mass points.
ANALYSIS OF CI SUBCOMPONENTS IN CELL CULTURE MEDIA OF HeLa CELLS AND DIPLOID HUMAN FETAL LUNG FIBROBLASTS (1973)

HeLa cells and diploid human fetal lung fibroblasts in culture synthesize an esterase, which is immunochemically and enzymatically identical with C1s of human serum. No C1q was found in the purified preparations or the concentrated crude cell culture fluids investigated. In the presence of Ca ++ the C1s of the cell cultures complexed with a substance, also present in the culture medium, possibly being C1r.
ChemInform Abstract: SYNTHESIS AND CHARACTERIZATION OF NOVEL 1H,3H‐NAPHTH(1,8‐CD)(1,2,6)OXADIBORINS (1985)

Abstract Synthesis and Characterization of Novel lH,3H‐Naphth[1,8‐cd][1,2,6]oxadiborins.
The application of BT-FinFET technology for sub 60nm DRAM integration (2005)

In this paper, the application of body tied FinFET is presented for a technology breakthrough beyond sub 60nm. DRAM on bulk Si substrate has been successfully integrated and the characteristics were compared to recess channel and planar cell array transistor DRAM. We present a comparison of three different device structures and show damascene BT-FinFET using NWL (negative word line) scheme with low channel for a highly manufacturable DRAM for sub 60nm technology node.