gebhart/patrepeval huggingface dataset:
5G Spectrum: enabling the future mobile landscape [Guest Editorial] (2015)

The arrival of the fifth generation (5G) is expected to come together with three important enablers. First, the densification of access nodes will continue. Second, 5G networks must be highly flexible and adapt to the dynamism of the traffic location and patterns. For this, some of the radio access network (RAN) functionalities will run in large computer centers, able to dynamically assign more or fewer units of computation to the virtual cells distributed in the network. Finally, a complex landscape of spectrum availability and access will emerge where multiple frequency bands, subject to different regulations including various forms of shared spectrum, are expected to be available to wireless communication systems.
Correction: Cardiovascular Risks Associated with Low Dose Ionizing Particle Radiation (2015)

In the Funding section, the grant number from the funder National Aeronautic and Space Administration has been updated by the funder. The updated grant number is: NNX11AD22G.
Vα and Vβ Public Repertoires Are Highly Conserved in Terminal Deoxynucleotidyl Transferase-Deficient Mice (2005)

T cell repertoires observed in response to immunodominant and subdominant peptides include private, i.e., specific for each individual, as well as public, i.e., common to all mice or humans of the same MHC haplotype, Valpha-Jalpha and Vbeta-Dbeta-Jbeta rearrangements. To measure the impact of N-region diversity on public repertoires, we have characterized the alphabeta TCRs specific for several CD4 or CD8 epitopes of wild-type mice and of mice deficient in the enzyme TdT. We find that V, (D), J usage identified in public repertoires is strikingly conserved in TdT(o/o) mice, even for the CDR3 loops which are shorter than those found in TdT(+/+) animals. Moreover, the 10- to 20-fold decrease in alphabeta T cell diversity in TdT(o/o) mice did not prevent T cells from undergoing affinity maturation during secondary responses. A comparison of the CDR3beta in published public and private repertoires indicates significantly reduced N-region diversity in public CDR3beta. We interpret our findings as suggesting that public repertoires are produced more efficiently than private ones by the recombination machinery. Alternatively, selection may be biased in favor of public repertoires in the context of the interactions between TCR and MHC peptide complexes and we hypothesize that MHCalpha helices are involved in the selection of public repertoires.
Compact Amplitude-Modulated, Phase-Analyzed Spectroscopy (CAMPAS) for Gas Analysis (2018)

Optical absorption in gases within an integrating sphere is determined by phase shifts of amplitude modulated laser light This technique could achieve performance advantages similar to those of FM radio over AM radio.
Effects of Side-Chain Length and Functionality on Polar Poly(dioxythiophene)s for Saline-Based Organic Electrochemical Transistors (2022)

Understanding the impact of side chains on the aqueous redox properties of conjugated polymers is crucial to unlocking their potential in bioelectrochemical devices, such as organic electrochemical transistors (OECTs). Here, we report a series of polar propylenedioxythiophene-based copolymers functionalized with glyme side chains of varying lengths as well as an analogue with short hydroxyl side chains. We show that long polar side chains are not required for achieving high volumetric capacitance (<i>C</i>*), as short hydroxy substituents can afford facile doping and high <i>C</i>* in saline-based electrolytes. Furthermore, we demonstrate that varying the length of the polar glyme chains leads to subtle changes in material properties. Increasing the length of glyme side chain is generally associated with an enhancement in OECT performance, doping kinetics, and stability, with the polymer bearing the longest side chains exhibiting the highest performance ([μ<i>C</i>*]<sub>OECT</sub> = 200 ± 8 F cm<sup>-1</sup> V<sup>-1</sup> s<sup>-1</sup>). The origin of this performance enhancement is investigated in different device configurations using <i>in situ</i> techniques (e.g., time-resolved spectroelectrochemistry and chronoamperometry). These studies suggest that the performance improvement is not due to significant changes in <i>C</i>* but rather due to variations in the inferred mobility. Through a thorough comparison of two different architectures, we demonstrate that device geometry can obfuscate the benchmarking of OECT active channel materials, likely due to contact resistance effects. By complementing all electrochemical and spectroscopic experiments with <i>in situ</i> measurements performed within a planar OECT device configuration, this work seeks to unambiguously assign material design principles to fine-tune the properties of poly(dioxythiophene)s relevant for application in OECTs.
Thermal Conductivity of Ultem(TradeMark)/Carbon Nanofiller Blends (2006)

In an effort to improve polymer thermal conductivity (TC), Ultem(TradeMark) 1000 was compounded with nano-fillers of carbon allotropes. Ultem(TradeMark) 1000 was selected since it is both solution and melt processable. As-received and modified multiwalled carbon nanotubes (MWCNTs), vapor grown carbon nanofibers (CNF) and expanded graphite (EG) were investigated. MWCNTs were modified by functionalizing the surface through oxidization with concentrated acids, mixing with an alkyl bromide, and addition of alkyl and phosphorus compounds after initial treatment with n-butyl lithium. Functionalization was performed to improve the TC compatibility between the resin and MWCNTs. It was postulated that this may provide an improved interface between the MWCNT and the polymer which would result in enhanced TC. The nano-fillers were mixed with Ultem(TradeMark) 1000 in the melt and in solution at concentrations ranging from 5 to 40 wt%. Ribbons were extruded from the blends to form samples where the nano-fillers were aligned to some degree in the extrusion direction. Samples were also fabricated by compression molding resulting in random orientation of the nano-fillers. Thermal properties of the samples were evaluated by Differential Scanning Calorimetry (DSC) and Thermal Gravimetric Analyzer (TGA). Tensile properties of aligned samples were determined at room temperature. The specimens were cut from the ribbons in the extrusion direction; hence the nano-fillers are somewhat aligned in the direction of stress. Typically it was observed that melt mixed samples exhibited superior mechanical properties compared to solution mixed samples. As expected, increased filler loading led to increased modulus and decreased elongation with respect to the neat polymer. The degree of dispersion and alignment of the nano-fillers was determined by high-resolution scanning electron microscopy (HRSEM). HRSEM of the ribbons revealed that the MWCNTs and CNFs were predominantly aligned in the flow direction. The TC of the samples was measured using a Nanoflash(TradeMark) instrument. Since the MWCNTs and CNF are anisotropic, the TC was expected to be different in the longitudinal (parallel to the nanotube and fiber axis) and transverse (perpendicular to the nanotube and fiber axis) directions. The extruded ribbons provided samples for transverse TC measurements. However, to determine the TC in the longitudinal direction, the ribbons needed to be stacked and molded under 1.7 MPa and 270 C. Samples were then obtained by cutting the molded block with a diamond saw. The largest TC improvement was achieved for aligned samples when the measurement was performed in the direction of MWCNT and CNF alignment (i.e. longitudinal axis). Unaligned samples also showed a significant improvement in TC and may be potentially useful in applications when it is not possible to align the nano-filler. The results of this study will be presented.
Author response for "The Novel Dual <scp>GIP</scp> and <scp>GLP</scp> ‐1 Receptor Agonist, Tirzepatide, Transiently Delays Gastric Emptying Similarly to Selective <scp>Long‐Acting GLP</scp> ‐1 Receptor Agonists" (2020)

The novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selectivelong-acting GLP-1 receptor agonists
Fanout of 2 Triangle Shape Spin Wave Logic Gates (2020)

Having multi-output logic gates saves much energy because the same structure can be used to feed multiple inputs of next stage gates simultaneously. This paper proposes novel triangle shape fanout of 2 spin wave Majority and XOR gates; the Majority gate is achieved by phase detection, whereas the XOR gate is achieved by threshold detection. The proposed logic gates are validated by means of micromagnetic simulations. Furthermore, the energy and delay are estimated for the proposed structures and compared with the state-of-the-art spin wave logic gates, and 16nm and 7nm CMOS. The results demonstrate that the proposed structures provide energy reduction of 25%-50% in comparison to the other 2-output spin-wave devices while having the same delay, and energy reduction between 43x and 0.8x when compared to the 16nm and 7nm CMOS while having delay overhead between 11x and 40x.
Optical tristable device by vertical and direct integration of heterojunction phototransistors and laser diodes (1992)

A light-controlled optical tristable device with an optical gain is actualized. The device has a configuration of vertical and direct integration of two heterojunction phototransistors (HPTs) on a laser diode (LD) along the cavity direction. An external optical input causes a bistable operation in one HPT+LD part. With the optical connection between two HPTs through the LD stripe, a bistable operation also occurs in the other HPT+LD part. The light-controlled optical tristability is achieved with the combination of the bistable operation in each HPT+LD part.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung (2018)

We describe lead compound MIDD0301 for the oral treatment of asthma based on previously developed positive allosteric α<sub>5</sub>β<sub>3</sub>γ<sub>2</sub> selective GABA<sub>A</sub> receptor (GABA<sub>A</sub>R) ligands. MIDD0301 relaxed airway smooth muscle at single micromolar concentrations as demonstrated with ex vivo guinea pig tracheal rings. MIDD0301 also attenuated airway hyperresponsiveness (AHR) in an ovalbumin murine model of asthma by oral administration. Reduced numbers of eosinophils and macrophages were observed in mouse bronchoalveolar lavage fluid without changing mucous metaplasia. Importantly, lung cytokine expression of IL-17A, IL-4, and TNF-α were reduced for MIDD0301-treated mice without changing antiinflammatory cytokine IL-10 levels. Automated patch clamp confirmed amplification of GABA induced current mediated by α<sub>1-3,5</sub>β<sub>3</sub>γ<sub>2</sub> GABA<sub>A</sub>Rs in the presence of MIDD0301. Pharmacodynamically, transmembrane currents of ex vivo CD4<sup>+</sup> T cells from asthmatic mice were potentiated by MIDD0301 in the presence of GABA. The number of CD4<sup>+</sup> T cells observed in the lung of MIDD0301-treated mice were reduced by an oral treatment of 20 mg/kg b.i.d. for 5 days. A half-life of almost 14 h was demonstrated by pharmacokinetic studies (PK) with no adverse CNS effects when treated mice were subjected to sensorimotor studies using the rotarod. PK studies also confirmed very low brain distribution. In conclusion, MIDD0301 represents a safe and improved oral asthma drug candidate that relaxes airway smooth muscle and attenuates inflammation in the lung leading to a reduction of AHR at a dosage lower than earlier reported GABA<sub>A</sub>R ligands.
Energy-based adaptive focusing: Optimal ultrasonic focusing using magnetic resonance guidance (2009)

Adaptive focusing of ultrasonic waves is performed under the guidance of a Magnetic Resonance (MR) system. The technique is based on the maximization of the ultrasonic wave intensity at a target point. The wave intensity is indirectly estimated from the local tissue motion induced at the chosen focus by the acoustic radiation force of the ultrasonic beam. A motion sensitive MR sequence is used to measure the resulting local tissue displacements. Based on the transmission of a set of spatially coded ultrasonic waves, a non iterative inversion process is used to estimate the phase aberrations induced by the propagation medium and to maximize the acoustical intensity at the target. Both programmable and physical aberrating layers introducing strong distortions (up to 2¿ radians) are recovered within acceptable errors (<0.8 rad). This non invasive technique is shown to accurately correct the phase aberrations in a phantom gel with negligible heat deposition and limited acquisition time. These refocusing performances demonstrate a major potential in the field of MR-Guided Ultrasound Therapy in particular for transcranial brain HIFU.
Neurocomputing and associative memories based on ovenized aluminum nitride resonators (2013)

Neurocomputing has been regarded as an intriguing alternative to the von Neumann architecture for computing systems, especially for such applications as pattern recognition, image processing, and associative memory. However, implementations using CMOS technology have largely been considered impractical due to the required circuit complexity and corresponding power consumption. In this paper we propose a novel configuration for a recently-developed ovenized aluminum nitride (AlN) resonator that is used as a thermally-tunable analog impedance for implementation of artificial neurons and synapses. We demonstrate and elaborate on our building blocks for artificial neurons and synapses using such resonators. Localized impedance tuning via multiple heaters on a single device enables a compact DAC (digital-to-analog converter) for programming artificial synapses and a simple-yet-efficient means for implementing artificial neurons. We also show the functionality of our proposed circuits using two pattern recognition examples based on compact circuit simulation models for ovenized AlN resonators. The resonator device models are characterized from measurement data.
Loading Molecular Hydrogen Cargo within Viruslike Nanocontainers (2008)

Fliehkräfte: Sechs C-Alkylpyrogallol[4]aren-Cavitandmoleküle werden durch Wasserstoffbrücken zu selbstorganisierten molekularen Kapseln verknüpft, die durch Scherkräfte auf einer schnell rotierenden Scheibe dissoziiert werden. In dem dünnen Film auf der Drehscheibe ist die Aufnahme von Wasserstoff möglich, der durch erneute Bildung der molekularen Hexamerkapseln in Lösung eingeschlossen wird.
Echo thresholds for reflections from acoustically diffusive architectural surfaces (2013)

When sound reflects from an irregular architectural surface, it spreads spatially and temporally. Extensive research has been devoted to prediction and measurement of diffusion, but less has focused on its perceptual effects. This paper examines the effect of temporal diffusion on echo threshold. There are several notable differences between the waveform of a reflection identical to the direct sound and one from an architectural surface. The onset and offset are damped and the energy is spread in time; hence, the reflection response has a lower peak amplitude, and is decorrelated from the direct sound. The perceptual consequences of these differences are previously undocumented. Echo threshold tests are conducted with speech and music signals, using direct sound and a simulated reflection that is either identical to the direct sound or has various degrees of diffusion. Results indicate that for a speech signal, diffuse reflections are less easily detectable as a separate auditory event than specular reflections of the same total energy. For a music signal, no differences are observed between the echo thresholds for reflections with and without temporal diffusion. Additionally, echo thresholds are found to be shorter for speech than for music, and shorter for spatialized than for diotic presentation of signals.
Integrated proteogenomic analysis of laser capture microdissected breast tumors (AACR 2017 Annual Meeting) (2017)

To investigate the proteogenomic landscape of breast cancer subtypes by integrating comprehensive transcriptomic, proteomic, and phosphoproteomic data, in a cohort with a substantial representation of African Americans, with a secondary objective of identifying druggable proteins that are differentially expressed in specific subtypes.
Effect of organic hydrophobic groups on the pore structure and thermal properties of waterglass-based silica xerogels (2017)

Hydrophobic silica xerogels containing trimethylsilyl (TMS) and dimethylsilyl (DMS) organic hydrophobic functional groups were synthesized using waterglass as the starting material. Five types of hydrophobic silica xerogels with varying surface coverages of the TMS and DMS groups were synthesized by changing the molecular structure of siloxane, which was used to introduce the hydrophobic moieties into the hydrogel and to investigate the resultant surface structures and thermal characteristics. The results revealed that the relative area of silica xerogels was smaller with a higher coverage of DMS groups. In addition, the thermal decomposition temperature of the silyl group shifted to higher temperatures, and the weight reduction during heating was also relatively limited in the above samples.
Poly(4-diphenylaminium-1,2-phenylenevinylene):  A High-Spin and Durable Polyradical (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTPoly(4-diphenylaminium-1,2-phenylenevinylene): A High-Spin and Durable PolyradicalMasahiro Takahashi, Takashi Nakazawa, Eishun Tsuchida, and Hiroyuki NishideView Author Information Department of Polymer Chemistry, Waseda University, Tokyo 169-8555, Japan Cite this: Macromolecules 1999, 32, 19, 6383–6385Publication Date (Web):August 26, 1999Publication History Received12 May 1999Published online26 August 1999Published inissue 1 September 1999https://pubs.acs.org/doi/10.1021/ma990745thttps://doi.org/10.1021/ma990745trapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views175Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalysts,Magnetic properties,Polymers,Quantum mechanics,Redox reactions Get e-Alerts
Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells (2018)

Over 160 mutations in superoxide dismutase 1 (SOD1) are associated with familial amyotrophic lateral sclerosis (fALS), where the main pathological feature is deposition of SOD1 into proteinaceous cytoplasmic inclusions. We previously showed that the tryptophan residue at position 32 (W32) mediates the prion-like propagation of SOD1 misfolding in cells, and that a W32S substitution blocks this phenomenon. Here, we used in vitro protein assays to demonstrate that a W32S substitution in SOD1-fALS mutants significantly diminishes their propensity to aggregate whilst paradoxically decreasing protein stability. We also show SOD1-W32S to be resistant to seeded aggregation, despite its high abundance of unfolded protein. A cell-based aggregation assay demonstrates that W32S substitution significantly mitigates inclusion formation. Furthermore, this assay reveals that W32 in SOD1 is necessary for the formation of a competent seed for aggregation under these experimental conditions. Following the observed importance of W32 for aggregation, we established that treatment of living cells with the W32-interacting 5-Fluorouridine (5-FUrd), and its FDA approved analogue 5-Fluorouracil (5-FU), substantially attenuate inclusion formation similarly to W32S substitution. Altogether, we highlight W32 as a significant contributor to SOD1 aggregation, and propose that 5-FUrd and 5-FU present promising lead drug candidates for the treatment of SOD1-associated ALS.
Enhanced Contactless Vital Sign Estimation from Real-Time Multimodal 3D Image Data (2020)

The contactless estimation of vital signs using conventional color cameras and ambient light can be affected by motion artifacts and changes in ambient light. On both these problems, a multimodal 3D imaging system with an irritation-free controlled illumination was developed in this work. In this system, real-time 3D imaging was combined with multispectral and thermal imaging. Based on 3D image data, an efficient method was developed for the compensation of head motions, and novel approaches based on the use of 3D regions of interest were proposed for the estimation of various vital signs from multispectral and thermal video data. The developed imaging system and algorithms were demonstrated with test subjects, delivering a proof-of-concept.
Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery (2017)

Physiologic barriers to drug delivery and selection for drug resistance limit survival outcomes in cancer patients. In this study, we present preclinical evidence that a subtumoricidal photodynamic priming (PDP) strategy can relieve drug delivery barriers in the tumor microenvironment to safely widen the therapeutic window of a nanoformulated cytotoxic drug. In orthotopic xenograft models of pancreatic cancer, combining PDP with nanoliposomal irinotecan (nal-IRI) prevented tumor relapse, reduced metastasis, and increased both progression-free survival and 1-year disease-free survival. PDP enabled these durable improvements by targeting multiple tumor compartments to (i) increase intratumoral drug accumulation by >10-fold, (ii) increase the duration of drug exposure above a critical therapeutic threshold, and (iii) attenuate surges in CD44 and CXCR4 expression, which mediate chemoresistance often observed after multicycle chemotherapy. Overall, our results offer preclinical proof of concept for the effectiveness of PDP to minimize risks of tumor relapse, progression, and drug resistance and to extend patient survival.<b>Significance:</b> A biophysical priming approach overcomes key treatment barriers, significantly reduces metastases, and prolongs survival in orthotopic models of human pancreatic cancer. <i>Cancer Res; 78(2); 558-71. ©2017 AACR</i>.