gebhart/patrepeval huggingface dataset:
SP-8356, a (1S)-(–)-verbenone derivative, exerts in vitro and in vivo anti-breast cancer effects by inhibiting NF-κB signaling (2019)

Breast cancer exhibits high lethality in women because it is frequently detected at an advanced stage and aggressive forms such as triple-negative breast cancer (TNBC), which are often characterized by metastasis through colonization of secondary tumors. Thus, developing therapeutic agents that target the metastatic process is crucial to successfully treat aggressive breast cancer. We evaluated SP-8356, an anti-inflammatory synthetic verbenone derivative, with respect to its regulation of breast cancer cell behavior and cancer progression. Treatment of SP-8356 arrested cell cycle and reduced growth in various types of breast cancer cells with mild cytotoxicity. Particularly, SP-8356 significantly reduced the motility and invasiveness of TNBC cells. Assays using an in vivo xenograft mouse model confirmed the cell-specific anti-proliferative and anti-metastatic activity of SP-8356. Functional studies revealed that SP-8356 suppressed serum response element-dependent reporter gene expression and NF-κB-related signaling, resulting in downregulation of many genes related to cancer invasion. We conclude that SP-8356 suppresses breast cancer progression through multimodal functions, including inhibition of NF-κB signaling and growth-related signaling pathways.
A hierarchical framework for modeling multimodality and emotional evolution in affective dialogs (2012)

Incorporating multimodal information and temporal context from speakers during an emotional dialog can contribute to improving performance of automatic emotion recognition systems. Motivated by these issues, we propose a hierarchical framework which models emotional evolution within and between emotional utterances, i.e., at the utterance and dialog level respectively. Our approach can incorporate a variety of generative or discriminative classifiers at each level and provides flexibility and extensibility in terms of multimodal fusion; facial, vocal, head and hand movement cues can be included and fused according to the modality and the emotion classification task. Our results using the multimodal, multi-speaker IEMOCAP database indicate that this framework is well-suited for cases where emotions are expressed multimodally and in context, as in many real-life situations.
Proceedings. Ohio Grape-Wine Short Course, 1973 (1973)

Research and the vineyard of the future / John Wiebe -- General consideration for vineyard site selection / James D. Utzinger -- Seasonal changes in soil moisture / Samuel W. Bone -- Vineyard preparation and planting ; Principles of pruning and training / G. A. Cahoon and R. G. Hill, Jr. -- Fruiting habits of the vine / John Wiebe -- Insects and new grape plantings / George W. Still -- Use and calibration of vineyard sprayers / Franklin R. Hall -- Pesticide safety and regulations / Acie C. Waldron -- Marketing and market associations / Paul Slade -- American wines for Americans / Maynard A. Amerine -- Grape varieties for wine making / J. F. Gallander and J. F. Stetson -- New methods of winemaking / Maynard A. Amerine -- New bulk handling system benefits grape industry / Dale E. Marshall -- Pectic enzymes in winemaking / Reubin A. Payne -- Methods of reducing acidity in winemaking ; Wine yeasts and their propagation for winery fermentation / Robert Beelman -- Incidence of malo-lactic fermentation in Ohio table wines / Thomas R. Graumlich and James F. Gallander -- Tartrate stability of Ohio wines / James F. Gallander -- Care of small cooperage ; A quality control program for wineries / Edwin R. Haynes -- Review of laws and wine regulations pertaining to the wine industry in the State of Ohio / E. J. Pritchard -- Review of federal alcohol regulations pertaining to wine making / Fred H. Murrell
Demonstrations of Wireless Autonomous Sensors for Aeronautical Applications (2010)

NANOLAB
Ly‐49‐independent inhibition of natural killer cell‐mediated cytotoxicity by a soluble major histocompatibility complex class I molecule (1994)

Natural killer (NK) cells lyse their targets in a non-major histocompatibility complex (MHC)-restricted manner, and the cytotoxicity can be inhibited by a number of MHC class I allele products, suggesting that NK cells may have a "positive receptor" that recognizes the target and a "negative receptor" that receives an inhibitory signal from class I. Since negative receptors could also exert their effect by masking a positive ligand, we have determined whether there may be a direct interaction between class I and an NK surface receptor by measuring cytotoxicity in the presence of a soluble class I molecule, Kd. Soluble Kd at micromolar concentrations could efficiently block NK cell cytotoxicity, suggesting that class I has a direct effect on cytotoxicity, rather than masking another target cell ligand. Inhibition required that Kd be at least divalent, probably because of its higher affinity or its ability to cross-link the NK surface receptor. In addition, the effect was independent of the peptide used to load Kd, and there was inhibition of cytotoxicity of NK cells derived from either H-2d or H-2b mice. Finally, depletion of NK cells expressing Ly-49 had no effect on the specific inhibition by Kd, raising the possibility that NK cells are endowed with additional negative receptors besides Ly-49. Taken together, these results suggest that there may be a family of NK receptors recognizing different class I alleles, which can receive negative signals by directly binding to class I on the target cell surface.
Total synthesis of 2-azaestratrienes (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of 2-azaestratrienesRobert J. Chorvat, John R. Palmer, and Raphael PappoCite this: J. Org. Chem. 1978, 43, 5, 966–972Publication Date (Print):March 1, 1978Publication History Published online1 May 2002Published inissue 1 March 1978https://pubs.acs.org/doi/10.1021/jo00399a036https://doi.org/10.1021/jo00399a036research-articleACS PublicationsRequest reuse permissionsArticle Views197Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
FLASH and minibeams in radiation therapy: the effect of microstructures on time and space and their potential application to protontherapy (2020)

After years of lethargy, studies on two non-conventional microstructures in time and space of the beams used in radiation therapy are enjoying a huge revival. The first effect called "FLASH" is based on very high dose-rate irradiation (pulse amplitude ≥10<sup>6</sup> Gy/s), short beam-on times (≤100 ms) and large single doses (≥10 Gy) as experimental parameters established so far to give biological and potential clinical effects. The second effect relies on the use of arrays of minibeams (<i>e.g.,</i> 0.5-1 mm, spaced 1-3.5 mm). Both approaches have been shown to protect healthy tissues as an endpoint that must be clearly specified and could be combined with each other (<i>e.g.,</i> minibeams under FLASH conditions). FLASH depends on the presence of oxygen and could proceed from the chemistry of peroxyradicals and a reduced incidence on DNA and membrane damage. Minibeams action could be based on abscopal effects, cell signalling and/or migration of cells between "valleys and hills" present in the non-uniform irradiation field as well as faster repair of vascular damage. Both effects are expected to maintain intact the tumour control probability and might even preserve antitumoural immunological reactions. FLASH <i>in vivo</i> experiments involving Zebrafish, mice, pig and cats have been done with electron beams, while minibeams are an intermediate approach between X-GRID and synchrotron X-ray microbeams radiation. Both have an excellent rationale to converge and be applied with proton beams, combining focusing properties and high dose rates in the beam path of pencil beams, and the inherent advantage of a controlled limited range. A first treatment with electron FLASH (cutaneous lymphoma) has recently been achieved, but clinical trials have neither been presented for FLASH with protons, nor under the minibeam conditions. Better understanding of physical, chemical and biological mechanisms of both effects is essential to optimize the technical developments and devise clinical trials.
MOPITT airborne validation instrument: MOPPITT-A (1999)

The Measurements of Pollution in the Troposphere-Aircraft (MOPITT-A) instrument is being constructed at the University of Toronto, as a primary data validation tool for the Terra based MOPITT instrument. MOPITT-A is designed to operate aboard a NASA ER-2 research aircraft and as such must be rugged and field serviceable while maintaining the same characteristics as the satellite instrument. The resulting instrument is a hybrid of flight space components with commercial devices. Calibration data generated by both instruments, at the U of T Instrument Calibration Facility (ICF) will play a key role in data validation.
Erratum to: Measurement of light-by-light scattering and search for axion-like particles with 2.2 nb−1 of Pb+Pb data with the ATLAS detector (2021)

Erratum to: Measurement of light-by-light scattering and search for axion-like particles with 2.2 nb −1 of Pb+Pb data with the ATLAS detector (Journal of High Energy Physics, (2021), 2021, 3, (243), 10.1007/JHEP03(2021)243)
Chemometrics applied to terahertz and Raman spectra for explosives analysis (2016)

Explosives detection has been performed in terahertz and Raman frequency bands using chemometric tools. We applied principal component models to compare the performances of terahertz and Raman spectra in explosives analysis, as well as binary and ternary explosive mixtures.
Reactive absorption of carbon dioxide in aqueous n-methyldiethanoloamine solutions catalysed with carbonic anhydrase in a rotating packed bed (RPB) (2023)

Studies on absorption of carbon dioxide in the rotating packed bed (RPB) were performed with two different types of metal foam packing, and two types of liquid absorbents: 30 wt.% solutions of N-methyldiethanolamine in water, with and without the addition of 0.2 wt.% of carbonic anhydrase. Different rotation speeds, gas flow rates and liquid flow rates were investigated. Results were evaluated using normalized interphase molar flow. Increased rotation speeds and phase flow rates positively affected the interphase mole flow of CO2, but high gas and liquid flow rates limited the operating window due to flooding. The addition of anhydrase significantly increased the absorption efficiency, but also narrowed the operating window. The addition of carbonic anhydrase resulted in an increase in the degree of absorption 2–5-fold for the analogous gas and liquid flow rates, compared to the amine without the biocatalyst. The highest normalized mole flow of 66.3 kmol h−1 m−3 was observed for NC1116 packing with the solvent containing anhydrase, while the highest normalized mole flow for solvent without catalyst was 26.2 kmol h−1 m−3. The results were compared with analogous absorption processes in a packed column and showed up to 50-fold higher mass transfer efficiency.
Multilevel Converters: An Enabling Technology for High-Power Applications Multilevel converters generate voltage and current waveforms of improved quality, that can be used to power drives for trains and other vehicles, and many other applications. (2009)

Multilevel converters are considered today as the state-of-the-art power-conversion systems for high-power and power-quality demanding applications. This paper presents a tutorialonthistechnology,coveringtheoperatingprincipleand the different power circuit topologies, modulation methods, technical issues and industry applications. Special attention is given to established technology already found in industry with more in-depth and self-contained information, while recent advances and state-of-the-art contributions are addressed with useful references. This paper serves as an introduction to the subject for the not-familiarized reader, as well as an update or reference for academics and practicing engineers working in the field of industrial and power electronics.
Management of Hsp90-Dependent Protein Folding by Small Molecule Targeting the Aha1 Co-Chaperone (2018)

Abstract The core cytosolic Hsp90 chaperone/co-chaperone complex plays a critical role in proteostasis management of human health and disease. To identify novel compounds that alter the ability of the Hsp90 co-chaperone Aha1 to modulate the ATPase activity found in multiple folding diseases ranging from steroid hormone receptor (SHR) sensitive prostate cancer to tauopathies associated with neurodegenerative diseases, we employed a h igh t hroughput s creening (HTS) assay to monitor selectively A ha1- s timulated H sp90 (ASH) ATPase activity. The ASH assay identified SEW04784 (SEW), a small molecule that disrupts ASH activity without inhibiting the basal Hsp90 ATPase activity. NMR analysis reveals that SEW binds to the C-terminal domain of Aha1 to disrupt its asymmetric binding to Hsp90 leading to abrogation of its chaperoning activity of Hsp90. SEW exhibits therapeutic potential by blocking the transcriptional activity of prostate cancer (PCa) associated variants of the androgen receptor (AR) in a cell-based model of PCa. Additionally, SEW exhibits the ability to clear toxic, phosphorylated tau aggregated species associated with tauopathies. By not directly impacting the basal ATPase function of the abundant and ubiquitous Hsp90, SEW could provide a therapeutic approach for mitigation of client-specific proteostatic disease.
III-V-on-Si DFB Laser With Co-Integrated Power Amplifier Realized Using Micro-Transfer Printing (2023)

A C-band III-V-on-Si distributed feedback (DFB) laser with co-integrated power amplifier was realized using micro-transfer printing. The DFB laser exhibits single mode operation around 1540 nm at 20°C. By driving the DFB laser and co-integrated power amplifier simultaneously, up to 14 dBm waveguide-coupled output power with over 28 dB side mode suppression ratio was achieved at an overall bias current of 270 mA.
A hybrid silicon colliding pulse mode-locked laser with integrated passive waveguide section (2012)

A hybrid silicon colliding pulse mode-locked laser with an integrated passive waveguide section is shown. The laser operates at 18GHz with a 20dB RF bandwidth of 1.6MHz.
Failures and verification solutions related to untimed paths in SOCs (2017)

A fundamental manifestation of the system-level nature of the modern SOC has been in the explosion of untimed paths on a chip. A single chip is no longer a textbook synchronous entity. Thanks to the use of complex design methodologies like asynchronous clock domains, interacting dynamic power domains, aggressive dynamic reset schemes, the wide-spread use of timing exceptions, GALS etc., large swaths of a chip interact asynchronously. Their analysis is outside the sweetspot of logic simulation + STA work-horse. Naturally, associated chip failures are being encountered in increased numbers and have acquired an insidious aura because they are detected late in the design process with adverse effects on budgets and business models. This urgent problem has driven rapid innovation in EDA, leading to a static verification framework comprising of a synthesis of semantic analysis and formal methods that enables sign-off level confidence for failure modes arising from such untimed paths. The success of this new class of EDA tools is evidenced, for example, by the fact that every single SOC today is signed-off using a dedicated clock-domain-crossing verification tool. This is a new paradigm in that these new EDA tools are targeted solutions for critical failure modes, representing a change from the incumbent practice of trying to make generic tools like simulators work for any type of design failure. Such a solution-oriented approach is a template to mitigate verification complexity arising from other failure modes.
Synthese von Cyclosporin und Analoga: Zusammenhang zwischen Struktur und immunsuppressiver Aktivität (1985)

Abstract Cyclosporin ist ein neues immunsuppressives Medikament, das 1983 unter dem Namen Sandimmun® auf den Markt kam. Diese Verbindung, die neue Aspekte in der selektiven Immunmodulation eröffnet, wurde aus einer Pilzkultur isoliert und als cyclisches Undecapeptid charakterisiert, das neben einer neuen Aminosäure mehrere N ‐methylierte Aminosäuren enthält. Die neue Aminosäure (4 R )‐[( E )‐2‐Butenyl]‐4, N ‐dimethyl‐ L ‐threonin (MeBmt) ließ sich nicht isolieren. Weil es möglich schien, daß diese Aminosäure für die pharmakologische Wirkung von Cyclosporin entscheidend ist, wurde sie enantiomerenrein synthetisiert. Der nächste Schritt war die Totalsynthese von Cyclosporin, die nicht nur als solche interessierte, sondern auch den Aufbau von Cyclosporin‐Analoga ermöglichte; da mit wurde der Weg zur Untersuchung der Beziehungen zwischen Struktur und immunsuppressiver Wirkung geebnet. Wesentlich für die Immunsuppression sind die Aminosäuren MeBmt, α‐Aminobuttersäure (Abu), Sarcosin (Sar) und N ‐Methylvalin (MeVal) in den Positionen 1, 2, 3 und 11, vielleicht aber auch noch größere Teile des Moleküls. Diese Information könnte genutzt werden, um neue chemische Leitstrukturen zu erkennen oder Pharmaka mit neuem Aktivitätsprofil zu finden.
Effects of glucose-dependent insulinotropic polypeptide receptor knockout and a high-fat diet on cognitive function and hippocampal gene expression in mice (2012)

It has been previously demonstrated that compromise of glucose-dependent insulinotropic polypeptide receptor (GIPR) action and chronic consumption of a high-fat diet can independently impair memory and learning ability, however, the underlying pathology remain to be elucidated. The present study investigated the effects of GIPR knockout (KO), alone and in combination with a high-fat diet, on aspects of cognitive function and hippocampal gene expression in mice. In object recognition tests, normal mice exhibited effective memory, preferring to investigate the novel over the familiar object. However, wild-type (WT) mice fed a high-fat diet and GIPR KO mice fed a standard or high-fat diet demonstrated no such discrimination, suggesting the impairment of memory function. This decline in cognitive function was associated with marked changes in the expression levels of hippocampal genes involved in memory and learning. The chronic consumption of a high-fat diet decreased the hippocampal gene expression levels of mammalian target of rapamycin (mTOR), neurotrophic tyrosine kinase receptor type 2 (NTRK2) and synaptophysin. Notably, the GIPR KO mice fed a high-fat diet exhibited no reduction in the hippocampal expression of synaptophysin expression, however, the GIPR KO mice fed a standard rodent maintenance diet exhibited reduced hippocampal expression of mTOR compared with the WT controls. These data highlighted the importance of intact GIPR signalling and dietary composition in modulating memory and learning, and hippocampal pathways involved in the maintenance of synaptic plasticity, including mTOR and NTRK2, appear to be key in this regard.
Fabrication of high aspect ratio microstructure arrays by micro reverse wire-EDM (2005)

In this paper, a machining technique to fabricate high aspect ratio microstructure arrays of a total volume less than 1 mm3 is developed. A method for determining the appropriate tension of the micro brass wire of the micro wire-EDM mechanism designed in our previous study is proposed, and a design for suppressing the vibration of the wire is implemented. In addition, a machining approach coined 'reverse wire-EDM' is developed. The micro wire-EDM mechanism is mounted on the worktable rather than on the machine head while the micro workpiece is clamped on the spindle instead of the worktable by a micro chuck. Machining is carried out by a horizontal moving micro brass wire of 20 µm diameter located beneath the micro workpiece to accelerate the removal of debris and to eliminate the heat accumulated in the micro gap during machining. The possible occurrence of short circuit discharge and thermal deformation of the machined part are therefore minimized. Experiments are conducted to machine various high aspect ratio miniature structures including a microstructure array of ten 10 µm sharp-edge lamellae at the tip, a microstructure array of ten 10 µm uniform thickness lamellae and a microstructure array of ten by ten 21 µm squared pillars. It is found that a microstructure array of an aspect ratio more than 33 is satisfactorily and precisely fabricated. The dimensional accuracy and geometric accuracy are less than 0.6 and 1.0 µm, respectively, while the surface roughness Rmax is kept within 0.44 µm.
Metallo-β-lactamase Domain-Containing Protein 1 (MBLAC1) Is a Specific, High-Affinity Target for the Glutamate Transporter Inducer Ceftriaxone (2017)

Ceftriaxone, a β-lactam antibiotic, has been reported to act independently of its antimicrobial actions to normalize perturbed central nervous system glutamate levels, principally by elevating expression of glial glutamate transporters. Identification of a specific, high-affinity target for ceftriaxone could significantly impact therapeutic development for multiple brain disorders, ranging from neurodegenerative disorders to addiction. Recently, we identified a glial-expressed Caenorhabditis elegans gene, swip-10, that encodes a metallo-β-lactamase domain-containing protein, and limits glutamate-dependent changes in dopamine neuron excitability. Bioinformatic analyses identified MBLAC1 as the likely mammalian orthologue of swip-10. Using cyanogen bromide immobilized ceftriaxone for affinity capture experiments and backscattering interferometry to monitor MBLAC1 binding of unmodified ceftriaxone, we obtained evidence for specific, high affinity (K<sub>D</sub> = 2.2 μM) binding of ceftriaxone to MBLAC1. We discuss our findings with respect to MBLAC1 as a potentially exclusive, high-affinity binding partner of ceftriaxone in the CNS, and the path forward in the development of novel, MBLAC1-based therapeutics.