gebhart/patrepeval huggingface dataset:
Enhanced Second-Harmonic Generation in Broken Symmetry III-V Semiconductor Metasurfaces driven by Fano resonance (2018)

We use broken symmetry III-V semiconductor Fano metasurfaces to substantially improve the efficiency of second-harmonic generation (SHG) in the near infrared, compared to SHG obtained from metasurfaces created using symmetrical Mie resonators.
Methyl B12Models Containing Unsubstituted Imidazole As an Axial Ligand Investigated by Structural and NMR Spectroscopic Methods. Evidence that μ-Imidazolato-Bridged Dimers Are Formed by Base Addition to Some Analogues with Macrocyclic Equatorial Ligands Incorporating BF2 (1999)

Imidazole (imH)-containing B12 model complexes that could possibly be deprotonated at the imidazole NH to form the corresponding imidazolato (im) complexes were investigated. Organomethyl complexes of cobaloxime and imine/oxime (I/O) analogues with equatorial ligands possessing an O−BF2−O moiety in place of each deprotonatable O−H- - -O moiety of standard models were prepared. In some cases, NMR spectroscopy revealed formation of μ-imidazolato (μ-im) dimers in methanol-d4 on addition of methoxide. The desired monomeric imidazolato species was not formed at a characterizable level. We present the X-ray crystal structures of LCo(DBF2)2CH3 (where L = imH, 4-t-BuimH) and [AsPh4][(μ-im)(Co(DBF2)2CH3)2] (DBF2 = the BF2-substituted monoanion of dimethylglyoxime). The latter confirms the NMR solution studies and is the first structure of a B12 model species bridged by an imidazolato moiety. We have also structurally characterized the related I/O complexes, [imHCo((DO)(DOBF2)pn)CH3]PF6 and [imHCo((DO)(DOH)pn)CH3]I. The former is the first reported I/O structure with a BF2 bridge. The structures presented here greatly increase the data available for B12 model derivatives with imidazole NH groups and nearly double the number of reported structures for the LCo(DBF2)2CH3 type of B12 models. As in all previous BF2-containing models, the equatorial moieties adopt the extended chair conformation. For the LCo(DBF2)2CH3 (L = imH, 4-t-BuimH) compounds, this arrangement leads to an L orientation that is unusual. Normally, the L plane bisects either the six-membered or the five-membered equatorial chelate rings (A and B orientations, respectively). The L orientation we find is intermediate between the typical A- and the B-type L orientations. Compared to that in A-type imHCo(DH2)2CH3 (DH = monoanion of dimethylglyoxime), the Co−NL distance for imHCo(DBF2)2CH3 was longer. We attribute this lengthening to the intermediate A-/B-type orientation. However, the distance shortens upon formation of the imidazolato dimer. The relationship of the μ-im ligand to both Co(DBF2)2CH3 moieties is also intermediate A/B and hence unusual. Therefore, this shortening probably does not have a steric cause but results from the better electron-donor ability of the imidazolato ligand. Measurements of 1JCH of Co−CH3 are consistent with this conclusion.
Atrial Natriuretic Peptide Antibody-Functionalised, PEGylated Multiwalled Carbon Nanotubes for Targeted Ischemic Stroke Intervention (2021)

Stroke is one of the major causes of disability and the second major cause of death around the globe. There is a dire need for an ultrasensitive detection tool and an effective and efficient therapeutic system for both detection and treatment of stroke at its infancy stage. Carbon nanotubes are promising nanomaterials for tackling these challenges. The loading of dexamethasone and decoration of PEGylated multiwalled carbon nanotube with atrial natriuretic peptide (ANP) antibody and fluorescein isothiocyanate for targeting ischemic site in the rat stroke model is presented here. Functionalisation of carbon nanotubes with dexamethasone (DEX), polyethylene glycol (PEG), fluorescein isothiocyanate (FITC), and ANP antibody caused a 63-fold increase in the D band intensity as illustrated by Raman. The characteristic band intensity increase was observed at 1636 nm following functionalisation of carbon nanotubes with polyethylene glycol and dexamethasone as confirmed by Fourier Transform Infrared. These findings have demonstrated the coupling capability of atrial natriuretic peptide antibody to DEX-PEG-CNTs. The baseline plasma atrial natriuretic peptide levels were ranging from 118 to 135.70 pg/mL prior to surgery and from 522.09 to 552.37 following common carotid artery occlusion. A decrease in atrial natriuretic peptide levels to 307.77 was observed when the rats were treated with FITC-DEX-PEG-ANP-CNTs, PEG-CNTs and DEX with a significant drop in the FITC-DEX-PEG-ANP-CNTs treated group. Fluorescence was detected in FITC-DEX-PEG-CNTs and FITC-DEX-PEG-ANP-CNTs treated ischemic stroke rats. The highest fluorescence intensity was reported in plasma (2179) followed by the kidney (1563) and liver (1507). These findings suggest a beneficial role that is played by the FITC-DEX-PEG-ANP-CNTs in the reduction of inflammation in the ischemic stroke induced rats that could induce a successful treatment of ischemic stroke.
Cardiovascular Effects of Dexmedetomidine Sedation in Children (2012)

Wong, Jackson; Steil, Garry M.; Curtis, Michelle; Papas, Alexandra; Zurakowski, David; Mason, Keira P.Author Information
OLED-embedded antennas for 2.4 GHz Wi-Fi and bluetooth applications (2017)

This is the first paper that demonstrates the possibility of utilizing transparent antennas to devise antennas with active display panels such LCDs and OLEDs with full invisibility. By using the entire region of an OLED of a smartwatch to devise a patch antenna, the radiation efficiency is confirmed to be maximized.
The inversion of diatomic spectra to estimates of population parameters (1985)

A bivariate polynomial representation of rovibrational population distributions is developed. This representation permits direct reduction of diatomic fluorescence spectra from chemical dynamics experiments to estimates of rotational and vibrational parameters by means of a linear least squares procedure.
Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis (2017)

With some advances in modern medicine (such as cancer chemotherapy, broad exposure to antibiotics, and immunosuppression), the incidence of opportunistic fungal pathogens such as Candida albicans has increased. Cases of drug resistance among these pathogens have become more frequent, requiring the development of new drugs and a better understanding of the targeted enzymes. Sterol 14α-demethylase (CYP51) is a cytochrome P450 enzyme required for biosynthesis of sterols in eukaryotic cells and is the major target of clinical drugs for managing fungal pathogens, but some of the CYP51 key features important for rational drug design have remained obscure. We report the catalytic properties, ligand-binding profiles, and inhibition of enzymatic activity of C. albicans CYP51 by clinical antifungal drugs that are used systemically (fluconazole, voriconazole, ketoconazole, itraconazole, and posaconazole) and topically (miconazole and clotrimazole) and by a tetrazole-based drug candidate, VT-1161 (oteseconazole: (R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol). Among the compounds tested, the first-line drug fluconazole was the weakest inhibitor, whereas posaconazole and VT-1161 were the strongest CYP51 inhibitors. We determined the X-ray structures of C. albicans CYP51 complexes with posaconazole and VT-1161, providing a molecular mechanism for the potencies of these drugs, including the activity of VT-1161 against Candida krusei and Candida glabrata, pathogens that are intrinsically resistant to fluconazole. Our comparative structural analysis outlines phylum-specific CYP51 features that could direct future rational development of more efficient broad-spectrum antifungals.
Melanocortin Antagonists Define Two Distinct Pathways of Cardiovascular Control by α- and γ-Melanocyte-Stimulating Hormones (1996)

Melanocortin peptides and at least two subtypes of melanocortin receptors (MC3-R and MC4-R) are present in brain regions involved in cardiovascular regulation. In urethane-anesthetized rats, unilateral microinjection of alpha-melanocyte-stimulating hormone (MSH) into the medullary dorsal-vagal complex (DVC) causes dose-dependent (125-250 pmol) hypotension and bradycardia, whereas gamma-MSH is less effective. The effects of alpha-MSH are inhibited by microinjection to the same site of the novel MG4-R/MC3-R antagonist SHU9119 (2-100 pmol) but not naloxone (270 pmol), whereas the similar effects of intra-DVC injection of beta-endorphin (1 pmol) are inhibited by naloxone and not by SHU9119. Hypotensive and bradycardic responses to electrical stimulation of the arcuate nucleus also are inhibited by ipsilateral intra-DVC microinjection of SHU9119. gamma-MSH and ACTH(4-10), but not alpha-MSH, elicit dose-dependent (0.1-12.5 nmol) pressor and tachycardic effects, which are much more pronounced after intracarotid than after intravenous administration. The effects of gamma-MSH (1.25 nmol) are not inhibited by the intracarotid injection of SHU9119 (1.25-12.5 nmol) or the novel MC3-R antagonist SHU9005 (1.25-12.5 nmol). We conclude that the hypotension and bradycardia elicited by the release of alpha-MSH from arcuate neurons is mediated by neural melanocortin receptors (MC4-R/MC3-R) located in the DVC, whereas the similar effects of beta-endorphin, a peptide derived from the same precursor, are mediated by opiate receptors at the same site. In contrast, neither MC3-R nor MC4-R is involved in the centrally mediated pressor and tachycardic actions of gamma-MSH, which, likely, are mediated by an as yet unidentified receptor.
Approaching fundamental energy consumption limits in optical communications (2013)

We study the fundamental energy consumption of fiber-optic communications links. We show that the quantum limit for the energy efficiency of a multi-span system deploying generalized on-off keying with photon-counting inline regeneration exceeds by orders of magnitude that of state-of-the-art systems employing inline optical amplification.
Pharmacokinetics and tolerance of repeated oral administration of 5-fluorocytosine in healthy dogs (2021)

Long term administration of 5-fluorocytosine was associated with cutaneous toxicity in healthy dogs. It suggests that pharmacotherapy should be adjusted to reduce the toxicity of 5-fluorocytosine in targeted chemotherapy.
Description and Capabilities of the Navcore-V GPS Receiver Engine (1991)

The NavCore V commercial Global Positioning System (GPS) receiver engine, announced by Rockwell International earlier in 1991, is a high
performance receiver designed to provide system integrators with the core GPS capability to support a variety of products. The NavCore V contains a five-channel GPS receiver and sufficient processing
capability to support rapid acquisition, robust GPS signal tracking, and 1 HZ navigation output data. The hardware and software designs represent an evolution from prior Rockwell military GPS receiver systems
with many new features added to enhance operation in the commercial environment.
The paper presents an overview of the NavCore V hardware design, particularly those aspects that support the low cost manul&uring required for a commercial receiver. The software is discussed from
the perspective of achieving maturity in a new commercial design. Recommendations for the integration of the engine into a variety of applications are included.
SYNFRIZZ: A first-in-human (FIH) study of a radiolabeled monoclonal antibody (Mab) targeting frizzled homolog 10 (FZD10) in patients (pts) with advanced synovial sarcomas (SyS). (2017)

11054 Background: Advanced SyS are rare tumors with limited curative options. FZD10 is highly expressed in SyS but not in normal adult tissue. OTSA101 is a MAb targeting FZD10, labelled with a radioisotope. Methods: We conducted a phase I, FIH study including adult pts with advanced, refractory SyS. In part 1, pts received OTSA101 labelled with In 111 used as radiotracer to assess biodistribution and tumor uptake. In part 2, pts with significant tumor uptake were randomized to receive OTSA101 labelled with 370MBq of Y 90 (Arm A) or 1110MBq Y 90 (Arm B). Primary endpoints were occurrence of unacceptable biodistribution /lack of tumor uptake in part 1 and occurrence of related adverse events (AEs) Grade ≥ 3 during the first 8 weeks following injection of Y 90 OTSA101 in part 2. Responses were assessed per RECIST 1.1. Results: From January 2012 to June 2015, 20 pts (10 females, median age 43, range 21-67) with advanced SyS were enrolled. Ten pts (50%) had sufficient tumor uptake to proceed to part 2 and 8 were randomized (Arm A: 3 and Arm B: 5). Two pts were not randomized due to worsening PS. During part 2, the most common Grade ≥ 3 AEs were haematological, including reversible lymphopenia, thrombocytopenia and neutropenia, and were more common in Arm B. One pt with SD after 12 weeks received a 2 nd injection of 90 Y-OTSA101, but experienced fatal hemoptysis. No objective response was observed. Best response was SD in 5/8 pts lasting up to 21 weeks for 1 pt. Conclusions: This FIH shows that radioimmunotherapy targeting FZD10 is feasible and safe in SyS pts. Tumor uptake was heterogeneous but sufficient to select 50% of pts for 90 Y-OTSA101 treatment. Due to limited sample size, further clinical investigations are needed to assess the therapeutic activity of 90 Y-OTSA101 with a recommended dose of 1110MBq of 90 Y. Clinical trial information: NCT01469975.
Ultra-Broadband Focusing with Diffractive Flat Lenses (2016)

Lenses are essential components in cameras, microscopes, telescopes and other imaging systems. Refractive lenses tend to be bulky due to their curvature; diffractive lenses can be planar, but suffer from debilitating chromatic aberrations. Recently, we have used computational techniques to design, fabricate and characterize flat, multi-level diffractive lenses that can focus three or more wavelengths of light at the same location. We call these super-achromatic diffractive lenses (SADLs).
Functional Dyspepsia Patients Have Lower Mucosal Cholecystokinin Concentrations in Response to Duodenal Lipid (2011)

Abdominal bloating symptoms are highly prevalent in subjects with functional GI disorders and are associated with increased healthcare utilization and reduced quality of life [APT 2010]. Altered intestinal transit and abnormal intraluminal fermentation have been proposed as possible pathophysiological mechanisms for these symptoms. We have previously demonstrated slower colonic transit in subjects with abdominal bloating compared to subjects without bloating. In this study we investigated the hypothesis that abdominal bloating symptoms are associated with abnormally increased intestinal fermentation.Aim: To investigate and compare the magnitude and site of intestinal fermentation in subjects with functional GI symptoms and bloating (FGI-B) and healthy controls (HC) by measuring pH in the GI lumen. Methods: We studied a total of 47 subjects; FGI-B (n=37) and HC (n=10). Intestinal intraluminal pH was used as a surrogate marker for intestinal fermentation. The intestinal pH levels were measured at different segments of the GI tract using a wireless motility capsule (WMC). Comparisons of transit time and pH variables between the groups were done using t-test; correlation analyses were done using Spearman Correlation Coefficients. Results: Intestinal pH levels were significantly lower at the proximal colon (Q1) of subjects with FGI-B compared to HC (mean pH 6.27 vs. 6.84; p=0.008) suggesting a significantly higher intraluminal intestinal fermentation at this segment of the GI tract in these subjects. The mean intraluminal colonic pH levels in the FGI-B group were also lower than that of HC at other segments of the large intestine; however, statistical differences were noticed only in the proximal and total colon. Mean colonic pH levels at the four (proximal to distal) colonic segments and the total colon are provided in the following Table. There were no noticeable differences between the groups in mean pH levels at any of the segments of the small bowel. The average total colonic pH significantly correlated with the total colonic transit time (r=0.34; p=0.014). However, no correlation was found between the average small bowel pH and small bowel transit time.Conclusions: We provide evidence of abnormal intestinal fermentation in subjects with functional GI symptoms and bloating. We demonstrate that bloating symptoms are associated with increased fermentation in the large rather than the small bowel. WMCmay be helpful in identifying underlying physiological abnormalities and guide treatment in patients with bloating symptoms. Mean intraluminal pH levels in subjects with abdominal bloating and healthy controls
State of the Art. Chronic Obstructive Pulmonary Disease, Inflammation, and Lung Cancer (2006)

Both lung cancer and chronic obstructive pulmonary disease (COPD) are associated with cigarette smoking, which, by generating reactive oxidant species, induces a chronic inflammatory state in the lung. Activation, particularly of nuclear factor-kappaB, occurs in both cancer and COPD, and expression of a number of genes is altered in both diseases. In lung cancer, DNA damage, lack of DNA repair, and genomic instability predominate, whereas matrix degradation, lack of repair, and an intense immune response predominate in COPD. The reasons for the different responses to a common inflammatory response induced by smoking remain to be determined, but likely lie in genetic polymorphisms in genes that regulate genome integrity in cancer and that regulate the immune response to tissue destruction in COPD.
Single trellis decoding of Reed-Solomon and convolutionalconcatenated code (1999)

By using the trellis approaches suggested by Wolf, block codes can be decoded by trellis decoding methods. The authors apply these methods to RS-convolutional concatenated codes and propose a decoding method using a single combined trellis structure comprising a convolutional code and RS code to easily obtain the soft decision decoding gain. The proposed decoding algorithm eliminates the need for a symbol interleaver, thus removing the time delay due to the symbol interleaver. The performance of the soft decision single trellis decoding of RS-convolutional concatenated codes over a fading channel is evaluated by simulation.
Molecular Imaging of N-linked Glycosylation Suggests Glycan Biosynthesis Is a Novel Target for Cancer Therapy (2010)

This study suggests that NLG inhibition is a novel therapeutic strategy for targeting EGFR and RTK signaling in both gliomas and other malignant tumors.
In situGravimetric Monitoring of Thermal Decomposition and Hydrogen Etching Rates of 6H-SiC(0001) Si Face (2009)

The thermal decomposition and hydrogen etching of a 6H-SiC(0001) Si-face were directly monitored using an in situ gravimetric monitoring system. The monitoring of the weight change of the 6H-SiC Si-face using this system clarified the dependences of the thermal decomposition and hydrogen etching rates on the substrate temperature. Although the thermal decomposition of the 6H-SiC Si-face above 1400 °C generated a graphite layer since only the Si atom directly desorbs from the surface, the etching of the 6H-SiC Si-face by hydrogen did not form this layer, and both Si and C atoms react with hydrogen. Moreover, the surface reaction of the 6H-SiC Si face with H2 and the resultant surface morphology were found to change at approximately 1250 °C.
Towards an Integrated QR Code Biosensor: Light-Driven Sample Acquisition and Bacterial Cellulose Paper Substrate (2018)

This paper addresses two key challenges toward an integrated forward error-correcting biosensor based on our previously reported self-assembled quick-response (QR) code. The first challenge involves the choice of the paper substrate for printing and self-assembling the QR code. We have compared four different substrates that includes regular printing paper, Whatman filter paper, nitrocellulose membrane and lab synthesized bacterial cellulose. We report that out of the four substrates bacterial cellulose outperforms the others in terms of probe (gold nanorods) and ink retention capability. The second challenge involves remote activation of the analyte sampling and the QR code self-assembly process. In this paper, we use light as a trigger signal and a graphite layer as a light-absorbing material. The resulting change in temperature due to infrared absorption leads to a temperature gradient that then exerts a diffusive force driving the analyte toward the regions of self-assembly. The working principle has been verified in this paper using assembled biosensor prototypes where we demonstrate higher sample flow rate due to light induced thermal gradients.
Polyphosphate‐selective porin OprO of Pseudomonas aeruginosa: expression, purification and sequence (1992)

The oprO gene of Pseudomonas aeruginosa codes for a polyphosphate-specific porin and terminates 458 bp upstream of the start codon for the phosphate-specific porin OprP. OprO was found to be expressed only under phosphate-starvation conditions in both wild-type and oprP::Tn501 mutant P. aeruginosa strains. However, unlike the rest of the genes of the Pho regulon, including oprP, expression of oprO required cells to be in the stationary growth phase in addition to phosphate starvation. Wild-type P. aeruginosa cells were grown in fermentor culture under these conditions and fractionated by selective solubilization in octylpolyoxyethylene detergent solution. Solubilized OprO was separated from OprP by application to a Mono Q FPLC column and elution with a salt gradient and shown to be functionally identical to cloned OprO produced in Escherichia coli. DNA sequencing of oprO showed the gene product to be highly homologous to OprP, with 76% identity and 16% conserved substitutions. Most genes of the Pho regulon possess a modified -35 region called the Pho box. Two such elements, separated by 4 bp were found in oprO. DNA sequencing also revealed a second Pho box in the oprP gene with the same spacing.
PoseShop: Human Image Database Construction and Personalized Content Synthesis (2012)

We present PoseShop--a pipeline to construct segmented human image database with minimal manual intervention. By downloading, analyzing, and filtering massive amounts of human images from the Internet, we achieve a database which contains 400 thousands human figures that are segmented out of their background. The human figures are organized based on action semantic, clothes attributes, and indexed by the shape of their poses. They can be queried using either silhouette sketch or a skeleton to find a given pose. We demonstrate applications for this database for multiframe personalized content synthesis in the form of comic-strips, where the main character is the user or his/her friends. We address the two challenges of such synthesis, namely personalization and consistency over a set of frames, by introducing head swapping and clothes swapping techniques. We also demonstrate an action correlation analysis application to show the usefulness of the database for vision application.
Sulpiride augmentation in people with schizophrenia partially responsive to clozapine (1997)

A subgroup of patients with chronic schizophrenia may substantially benefit from sulpiride addition to clozapine.
Intraneural active probe for bidirectional peripheral nerve interface (2017)

Advanced bionic prosthetics that can restore both the motor functionality and sensory perception of an amputee, require high-resolution recording and stimulation interfaces targeting the peripheral nervous system (PNS). To provide high nerve fiber selectivity, we propose a low-noise (3.67μVrms) low-power (2.24mW) and high-density CMOS microelectrode probe for intra-neural implantation. The probe is composed of two ICs, encapsulated in a biocompatible and hermetic package, each featuring 64 recording and 16 stimulation electrodes. A backend IC digitizes the recorded signals at 31.25kS/s and provides spike detection.