gebhart/patrepeval huggingface dataset:
096 Biochemical Analysis of Chronic Wounds Treated with the V.A.C.® System (2004)

Introduction : Proinflammatory cytokines TNF‐α, IL‐1β, and matrix metalloproteinases (MMPs) are elevated in chronic wounds and their levels decrease during healing. TNF‐α and IL‐1β stimulate the production of MMPs which cause degradation of growth factors. Wound fluid from the V.A.C. ® is of interest when investigating the mechanisms by which V.A.C. ® therapy aids in wound healing. We hypothesize that the clinical improvement in healing of chronic wounds by the V.A.C. ® system occurs by a shift from a chronic cytotoxic environment to a more conducive acute healing wound environment. This study aims at understanding the molecular and mechanistic consequences of V.A.C. ® therapy on chronic wound healing. Methods : Wound fluid collected from two patients with Stage IV pressure ulcers at baseline, 24hours, 72hours, and 7 days following V.A.C. ® therapy. Concentrations of TNF‐α, IL‐1β, MMP‐2, ‐3, ‐9, TIMP‐2, and total protein were determined using ELISA. Results : TNF‐α levels in wound fluids decreased from baseline levels in two patients following 3 days of treatment. Similarly, levels of MMP‐3, MMP‐9 and TIMP‐2 decreased from baseline following 3 days of treatment. There were no consistent trends in IL‐1β &amp; MMP‐2. Conclusion : The preliminary results from this study suggest that improved wound healing with V.A.C. ® therapy is related to decreased levels of proinflammatory cytokines, MMPs and TIMP‐2 in wound fluid.
Enhanced thermal decomposition kinetics of poly(lactic acid) sacrificial polymer catalyzed by metal oxide nanoparticles (2015)

Poly Lactic Acid (PLA) and 1 wt% PLA/Fe<sub>2</sub>O<sub>3</sub>, PLA/CuO, PLA/Bi<sub>2</sub>O<sub>3</sub> composites are prepared by solvent evaporation casting and their enhanced thermal decomposition kinetics catalyzed by low loading metal oxide nanoparticles are studied.
Corneal grafting assisted by wavelength‐optimised ultrashort pulser lasers (2010)

Abstract Purpose We realized an innovative device for ocular surgery by ultrafast pulse laser optimised for corneal grafting. Methods We constructed a demonstrator device that reproduces surgical conditions of corneal transplant. It is thus possible to realize with the help of an easy handling automatised interface all the kinds of already existing corneal transplants. Also, in order to maximize the spatial quality of the beam, a wavefront correction system using a deformable mirror module has been added. The Demonstrator contains an erbium fiber laser emitting at 1,6 microns. This laser delivers a beam of a few Joule with pulse duration of 700 femtoseconds and a repetition rate of 100‐200 KHz. It includes deformable mirrors permitting horizontal displacements and a wavefront sensor. It also contains the administration system of the laser beam. Results The experiments carried out with a surgical tunable source confirmed the initial assumptions: the penetration depth is limited to wavelengths close to 1 microns. When increasing the wavelength, the drop of the scattering compensates the absorption and therefore the penetration depth is slowly varying when increasing the wavelength. The laser does not penetrate near the maximum of the water absorption band located at 1,45 microns. However, the use of a wavelength of 1,6 micros enables an important increasing of penetration depth (factor 3) while conserving the same energy of current technologies. Conclusion The use of a laser source with a wavelength corresponding to the window of transparency of the cornea (1,65 microns) permits to increase both the penetration depth of an ultrafast laser source and the cut quality.
Backside Integrated Circuit Magnetic Field Imaging with a Quantum Diamond Microscope (2020)

Abstract We present a new method for backside integrated circuit (IC) magnetic field imaging using Quantum Diamond Microscope (QDM) nitrogen vacancy magnetometry. We demonstrate the ability to simultaneously image the functional activity of an IC thinned to 12 µm remaining silicon thickness over a wide fieldof- view (3.7 x 3.7 mm2). This 2D magnetic field mapping enables the localization of functional hot-spots on the die and affords the potential to correlate spatially delocalized transient activity during IC operation that is not possible with scanning magnetic point probes. We use Finite Element Analysis (FEA) modeling to determine the impact and magnitude of measurement artifacts that result from the specific chip package type. These computational results enable optimization of the measurements used to take empirical data yielding magnetic field images that are free of package-specific artifacts. We use machine learning to scalably classify the activity of the chip using the QDM images and demonstrate this method for a large data set containing images that are not possible to visually classify.
Data from Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector Functions (2023)

&lt;div&gt;Abstract&lt;p&gt;SLAMF6 is a homotypic receptor of the Ig-superfamily associated with progenitor-exhausted T cells. Here we show that in humans, SLAMF6 has three splice isoforms involving its V-domain. Although the canonical receptor inhibited T-cell activation through SAP recruitment, the short isoform SLAMF6&lt;sup&gt;Δ17–65&lt;/sup&gt; had a strong agonistic effect. The costimulatory action depended on protein phosphatase SHP1 and led to a cytotoxic molecular profile mediated by the expression of TBX21 and RUNX3. Patients treated with immune checkpoint blockade showed a shift toward SLAMF6&lt;sup&gt;Δ17–65&lt;/sup&gt; in peripheral blood T cells. We developed splice-switching antisense oligonucleotides (ASO) designed to target the relevant SLAMF6 splice junction. Our ASOs enhanced SLAMF6&lt;sup&gt;Δ17–65&lt;/sup&gt; expression in human tumor-infiltrating lymphocytes and improved their capacity to inhibit human melanoma in mice. The yin-yang relationship of SLAMF6 splice isoforms may represent a balancing mechanism that could be exploited to improve cancer immunotherapy.&lt;/p&gt;&lt;/div&gt;
Utility of Cystoscopy During Hysterectomy (2012)

Our data support selective rather than universal cystoscopy at the time of hysterectomy.
Coherent Tunneling in Fe-8 Molecular Nanomagnets: Response to the Comment by Bellessa (arXiv:cond-mat/0006441) (2000)

Response to the Comment by Bellessa (arXiv:cond-mat/0006441).
Generating Configurable Hardware from Parallel Patterns (2016)

In recent years the computing landscape has seen an increasing shift towards specialized accelerators. Field programmable gate arrays (FPGAs) are particularly promising for the implementation of these accelerators, as they offer significant performance and energy improvements over CPUs for a wide class of applications and are far more flexible than fixed-function ASICs. However, FPGAs are difficult to program. Traditional programming models for reconfigurable logic use low-level hardware description languages like Verilog and VHDL, which have none of the productivity features of modern software languages but produce very efficient designs, and low-level software languages like C and OpenCL coupled with high-level synthesis (HLS) tools that typically produce designs that are far less efficient. Functional languages with parallel patterns are a better fit for hardware generation because they provide high-level abstractions to programmers with little experience in hardware design and avoid many of the problems faced when generating hardware from imperative languages. In this paper, we identify two important optimizations for using parallel patterns to generate efficient hardware: tiling and metapipelining. We present a general representation of tiled parallel patterns, and provide rules for automatically tiling patterns and generating metapipelines. We demonstrate experimentally that these optimizations result in speedups up to 39.4× on a set of benchmarks from the data analytics domain.
Abstract 52: Human Grk4γ142v, Via Histone Deacetylase 1, Produces At1r-dependent Hypertension (2013)

Human gene variants account for only a small proportion of essential hypertension in humans and have not been shown to produce hypertension in transgenic mice. The association between hypertension and 11 allelic variants of 8 candidate genes in humans (n=1074) was studied. We also evaluated the response to angiotensin receptor blockers (ARBs) in humans (n=681) and transgenic mice generated to express the human wild-type G protein-coupled receptor kinase 4γ ( hGRK4 γ WT ) or the 142V allele (hGRK4γ 142V ). hGRK4 γ variants ( R65L , A142V , and A486V ) were associated with essential hypertension; hGRK4γ 142V , by itself, predicted the hypertensive phenotype (60% accuracy); hGRK4γ 142V also interacted with GNB3 and PAI-1 . Human hypertensive carriers of hGRK4 γ 142V (n=68) had a greater decrease in systolic blood pressure (SBP mm Hg, 19.36, vs. 14.58, P=0.001) in response to ARBs than non-carrier (n=135) hypertensives. hGRK4γ WT transgenic mice (anesthetized, n=42; conscious [n=12, day=118±0.8, night=131±1]) were normotensive while hGRK4γ 142V mice (anesthetized, n=54;conscious [n=12, day=128±2, night=148±3]) had hypertension, increased renal AT 1 R expression due to decreased histone deacetylase 1 (HDAC1) activity, a greater pressor response to angiotensin II (1000 ng/kg/minX30’)(n=6-9/group, WT=Δ+14±4%, 142V=Δ+26±3%), and a greater fall in SBP with candesartan (2mg/kg/dayX4d) (n=7/group, WT=Δ-5±2%,142V=Δ-29±3%); deletion of Agtr1a normalized the high BP of hGRK4γ 142V mice (n=5-13/group). To determine the role of renal HDAC1 on BP, HDAC1 was silenced with HDAC-siRNA. Renal-specific HDAC1, but not HDAC2, silencing increased SBP (HDAC1-siRNA=112±5; mock=91±2; P&lt;0.004, n=5/group). The BP response to ARBs was greater in HDAC1-siRNA- than mock-treated mice. These studies show that hGRK4γ 142V is associated with human essential hypertension, produces AT 1 R-sensitive hypertension in hGRK4γ 142V transgenic mice, and predicts a greater decrease in BP in response to ARBs in humans with essential hypertension and hGRK4γ 142V transgenic mice. This is the first demonstration of a concordance between rodents and humans for genetics, signaling pathway, and pharmacogenetics of essential hypertension.
A cable feeder tool for robotized cable winding (2014)

Cable winding is an alternative technology to create stator windings in large electrical machines. Today such cable winding is performed manually, which is very repetitive, time-consuming and therefore also expensive. This paper presents the design, function and control system of a developed cable feeder tool for robotized stator cable winding. The presented tool was able to catch a cable inside a cable guiding system and to grab the cable between two wheels. One of these wheels was used to feed cable through the feeder. A control system was integrated in the tool to detect feeding slippage and to supervise the feeding force on the cable. Functions to calculate the cable feed length, to release the cable from the tool and for positional calibration of the stator to be wound were also integrated in the tool. In validating the function of the cable feeder tool, the stator of the linear generator used in the Wave Energy Converter generator developed at Uppsala University was used as an example. Through these experiments, it was shown that the developed robot tool design could be used to achieve automated robotized cable winding. These results also complied with the cycle time assumptions for automated cable winding from earlier research. Hence, it was theoretically indicated that the total winding cycle time for one Uppsala University Wave Energy Converter stator could be reduced from about 80 h for manual winding with four personnel to less than 20 h in a fully developed cable winding robot cell. The same robot tool and winding automation could also be used, with minor adjustments, for other stator designs. • A cable feeder tool for robotized cable winding has been developed and constructed. • Experiments validating automated cable winding assembly in this tool are presented. • The functions of the tool is explained in detail and validated through experiments. • An Uppsala University Wave Energy Converter cable wound stator is used as the reference. • The cable feeder tool can be used for different stator designs, winding patterns and cables.
Comparative localization of cystathionine β‐synthase and cystathionine γ‐lyase in retina: Differences between amphibians and mammals (2007)

Hydrogen sulfide (H(2)S) is a gaseous neuromodulator that can be synthesized by the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL). In this study we examined H(2)S as a potential neuromodulator in vertebrate retina. CBS-like immunoreactivity (LI) was found in somas in the inner nuclear layer and as punctate staining in the inner and outer plexiform layers in the salamander retina. CGL-LI was most clearly characterized in salamander, where it was localized in Müller cells. Western blots indicated proteins with the correct molecular weights for both enzymes in both species for liver and cerebellum. Correct molecular weight proteins were identified for both CGL and CBS in salamander retina. The CBS antiserum did not recognize the correct molecular weight protein in mouse retina but the CGL antiserum recognized the correct molecular weight protein for mouse retina. Enzyme assays indicated both CGL and CBS enzyme activity in all three tissues in the salamander. There was good CBS activity in the liver and cerebellum of the mouse but no activity in the retina. CGL activity was clearly present only in the mouse liver, with only trace activity in the cerebellum and retina. In conclusion, both CBS and CGL are present in the amphibian retina, which suggests either a potential role for H(2)S as a gaseous neuromodulator in both neurons and glia in the retina or a requirement for cysteine and glutathione synthesis via the transsulfuration pathway as a defense against oxidative stress.
Discovery of fused azetidines as novel selective α4β2 neuronal nicotinic receptor (NNR) agonists (2005)

Abstract An efficient synthesis of (1 R ,5 S )-6-(5-cyano-3-pyridinyl)-3,6-diaza-bicyclo[3.2.0]heptane A-366833 , a novel potent selective neuronal nicotinic receptor (NNR) agonist, is described. The enantiomerically pure pharmacophore benzyl (1 S ,5 S )-3,6-diaza-bicyclo[3.2.0]heptane-3-carbamate was successfully constructed from benzyl N -allyl- N -(2-hydroxyimino-ethyl)-carbamate through a convenient approach including an intramolecular [1,3]-dipolar cycloaddition, reductive ring-opening reaction, chiral resolution, and intramolecular cyclization. Subsequent N -arylation of the pharmacophore with 3-bromo-5-cyanopyridine and N -Cbz deprotection with trifluoroacetic acid furnished A-366833 .
Mechanics of hearing 2017: Moderated discussion III (2018)

At the 13th International Workshop on the Mechanics of Hearing (MoH), held at Brock University (Ontario, Canada) in June 2017, several discussion forums were held where participants actively engaged in critical discussion dealing with workshop topics/themes. The following is an edited transcript of a recorded discussion session that took place on June 24. All participants knew that the session was being recorded. We note that the discussion was relatively spontaneous in nature, and the transcription subject to interpretation and editing (for clarity). Additionally, minor changes (e.g., slight reordering, editing for conciseness) were made to help improve readability. As such, this transcript may not definitively represent the views of the participants, nor represent a consensus of experts in the field. Readers are advised to consult additional literature.
Supplementary Figure 6 from RapidCaP, a Novel GEM Model for Metastatic Prostate Cancer Analysis and Therapy, Reveals Myc as a Driver of <i>Pten</i>-Mutant Metastasis (2023)

&lt;p&gt;PDF file 218K, Histological analysis of castration resistant prostate cancer reveals the Akt-Myc switch&lt;/p&gt;
Translation of murine leukemia virus RNA in cell-free systems from animal cells (1976)

The virion RNA of Moloney murine leukemia virus (MuLV) has been translated in eukaryotic cell-free systems derived from mouse L- and human HeLa cells. In both systems at least three polypeptides, approximately 60,000, 70,000, and 180,000 in apparent molecular weight, were formed in response to the added 35S MuLV RNA. All three polypeptides were precipitable with antiserum to detergent-disrupted MuLV. Fingerprint analysis of tryptic digests indicated that all three contain anino acid sequences in common with each other and with the major methionine-containing structural proteins of the virion.
Retardation and reduction of pulse distortion by group-velocity dispersion through pulse shaping (1995)

We show that a reduction in the pulse distortion caused by chromatic dispersion can be achieved through pulse shaping. We argue that a simple binary phase mask in the Fourier plane of the laser spectrum can improve the transmission of short pulses in a dispersive channel through reduced broadening. The argument was tested experimentally, and a good agreement was found with the theory.
ChemInform Abstract: REACTIONS OF N‐ARYL NITROGEN OXIDES PART 1, SELECTIVE ORTHO CHLORINATION IN THE REACTIONS OF ARYL NITRONES AND AMINE OXIDES WITH THIONYL CHLORIDE OR PHOSGENE (1974)

Abstract Aus den N‐Aryl‐nitronen (I) erhält man bei der Behandlung mit Thionylchlorid oder Phosgen über Zwischenstufen wie (II) und deren Umlagerung zu (III) die o‐Chlorirnine (IV).
Parameter extraction for a power diode circuit simulator model including temperature dependent effects (2003)

Power electronics designers need accurate models of power diodes to perform simulations of the systems they are designing. The diode models should be accurate under a wide variety of operating conditions. In particular temperature dependencies should be accurately modeled. Physics-based models appear to be the best choice to meet these requirements. On the other hand, complicated parameter extraction procedures discourage use of these models by practicing engineers. In this work we explore the possibility of using a sophisticated physics-based diode model utilizing at most three parameters obtained directly or estimated from the manufacturer's data sheets. In order to validate the proposed approach, several diodes with different characteristics are tested under different conditions and a wide temperature range from -150 to 150/spl deg/C. Experimental results are compared with simulations.
InsightVideo: toward hierarchical video content organization for efficient browsing, summarization and retrieval (2005)

Hierarchical video browsing and feature-based video retrieval are two standard methods for accessing video content. Very little research, however, has addressed the benefits of integrating these two methods for more effective and efficient video content access. In this paper, we introduce InsightVideo, a video analysis and retrieval system, which joins video content hierarchy, hierarchical browsing and retrieval for efficient video access. We propose several video processing techniques to organize the content hierarchy of the video. We first apply a camera motion classification and key-frame extraction strategy that operates in the compressed domain to extract video features. Then, shot grouping, scene detection and pairwise scene clustering strategies are applied to construct the video content hierarchy. We introduce a video similarity evaluation scheme at different levels (key-frame, shot, group, scene, and video.) By integrating the video content hierarchy and the video similarity evaluation scheme, hierarchical video browsing and retrieval are seamlessly integrated for efficient content access. We construct a progressive video retrieval scheme to refine user queries through the interactions of browsing and retrieval. Experimental results and comparisons of camera motion classification, key-frame extraction, scene detection, and video retrieval are presented to validate the effectiveness and efficiency of the proposed algorithms and the performance of the system.
Tight-binding molecular-dynamics study of amorphous carbon (1993)

The structural and electronic properties of amorphous carbon are studied with tight-binding molecular-dynamics simulations. An amorphous carbon structure with 216 atoms obtained from our simulation gives a structure factor S(Q) in very good agreement with the results of neutron scattering from a sputtered a-C sample. We found that the amorphous structure consists of graphitelike fragments embedded in a matrix of both twofold and fourfold coordinated atoms. We also found a small pseudogap in the electronic density of states at the Fermi level.
Investigating the Cusp Between Dendritic and Supermolecular Architectures in Self‐Organizing Liquid Crystals (2023)

Abstract Liquid Crystals are thought of as being complex fluids, underpinned by self‐assembly and self‐organisation within partially ordered fluids, and which sit between solid and liquid states of matter. The realm of the field stretches from low molar mass to polymeric materials, from organic to inorganic substances, and from being functional materials to biological organelles. In this article, we explore the cusp of the change over from nano‐ to macro‐sciences through the formation of ‘supermolecular’ systems, and we debate if such materials are in fact oligomers or materials having giant molecules possessing discrete chemical constitutions? We performed this investigation by synthesising mesogenic materials based upon difluoroterphenyls, terminally substituted with a chiral motif based on ( S )‐2‐octanol, and which could be appended onto a variety of siloxane scaffolds. We studied the structures and properties of six mesomorphic materials in which we systematically increased the number of mesogenic units attached to the scaffold.
Pancam Multispectral Imaging Results from the Spirit Rover at Gusev Crater (2004)

Panoramic Camera images at Gusev crater reveal a rock-strewn surface interspersed with high- to moderate-albedo fine-grained deposits occurring in part as drifts or in small circular swales or hollows. Optically thick coatings of fine-grained ferric iron-rich dust dominate most bright soil and rock surfaces. Spectra of some darker rock surfaces and rock regions exposed by brushing or grinding show near-infrared spectral signatures consistent with the presence of mafic silicates such as pyroxene or olivine. Atmospheric observations show a steady decline in dust opacity during the mission, and astronomical observations captured solar transits by the martian moons, Phobos and Deimos, as well as a view of Earth from the martian surface.
Development of a portable active interrogation system for characterizing special nuclear material (2019)

Detection, identification, and characterization of shielded Special Nuclear Material (SNM), and especially of Highly Enriched Uranium (HEU), often require active interrogation. Active interrogation with neutrons or high energy photons induces fission and thus causes the emission of characteristic gamma and neutron radiation. The detection of the emitted radiation with simple detector systems often only indicates the presence of SNM. Analysis of the correlations of the neutron emissions can provide characteristics of a material, such as multiplication and mass. Such analyses are used in well counters for characterizing SNM. Our system consists of a portable pulsed neutron generator and a portable list-mode neutron detection system. The neutron correlations between the intense interrogating pulses from the neutron generator are analyzed to determine characteristics of the SNM. After the last interrogating pulse, the die away is analyzed to identify the type of SNM. We report data from a variety of SNM objects and present preliminary analysis results.