gebhart/patrepeval huggingface dataset:
Hip, Knee and Ankle Joint Power in Three Weighted Squat Jump Techniques (2017)

INTRODUCTION: The vertical jump is one movement used to train and assess power output of the legs. Specifically, loaded vertical jumps have been proven to increase vertical jump performance in a training environment. PURPOSE: The purpose of this study is to evaluate three loaded vertical jump training methods: the barbell back squat jump (BB), the goblet squat jump (GB) and the dumbbell squat jump (DB) on lower limb, peak joint powers. METHODS: Nine male volunteers (age: 22.1 ± 1.2 yrs; Ht: 1.75 ± 0.05 m; Wght: 76.0 ± 10.0 Kg) with at least 2 yrs experience in weight lifting performed 5 trials in each condition of the goblet, back and dumbbell squat jumps (randomized order) utilizing 10% of their 1-RM back squat as the experimental weight. Ten infrared cameras (200Hz) and an AMTI force plate (1,000Hz) collected a full body, 3-marker per segment model and ground reaction force data. All data were smoothed using a 4th order Butterworth filter of 20Hz. GRF data were interpolated down to 200Hz to temporally align camera and force data. Commercial software was used to calculate 3D lower limb joint angles, moments and powers via inverse dynamics. Differences in peak ankle, knee and hip power values during the jump were compared with RMANOVA (alpha ≤ 0 .05) with Bonferroni post hoc tests. RESULTS: DB resulted in greater COM maximal jump height compared to BB (p < .0001) and GB (p = .005). No differences were noted for peak hip joint power (p = .23). Peak knee power was larger for DB compared to BB (p = .01) but not GB (p = .06). At the ankle, DB produced greater power than BB (p = .01) and GB (p < .001); but no differences were noted between GB and BB (p = .40). CONCLUSION: DB produced a greater COM maximal jump height, and greater knee and ankle powers. DB may be a superior training tool to produce increased knee and ankle joint powers.
Statistical Analysis and Simulation of Pentad Distributions of Stereoblock Polypropylenes (1998)

A method for simulating the microstructure of atactic−isotactic stereoblock polypropylene is presented. This method uses a computer program to generate stereosequences based on alternating blocks of isotactic and atactic stereosequences. Trends in observable stereochemical pentad distributions are examined, revealing that the pentad distributions become invariant above block lengths of 50 monomer units. These simulations reveal that two polymers with identical observable isotactic pentad distributions may have very different microstructures and thus different physical properties. The spectrum of an actual polymer is compared to the simulations, and it is revealed that many possible block lengths give reasonable fits but that similar values for weight fractions are obtained for each fit.
Re: Ligand-Dependent Corepressor Acts as a Novel Androgen Receptor Corepressor, Inhibits Prostate Cancer Growth, and is Functionally Inactivated by the Src Protein Kinase (2012)

No AccessJournal of UrologyInvestigative Urology1 Jul 2012Re: Ligand-Dependent Corepressor Acts as a Novel Androgen Receptor Corepressor, Inhibits Prostate Cancer Growth, and is Functionally Inactivated by the Src Protein Kinase Anthony AtalaM.D. Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.03.075AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Ligand-Dependent Corepressor Acts as a Novel Androgen Receptor Corepressor, Inhibits Prostate Cancer Growth, and is Functionally Inactivated by the Src Protein Kinase." The Journal of Urology, 188(1), p. 326 © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 188Issue 1July 2012Page: 326 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
OS16-4-3 Joining Method of Laminate Film Used for Packaging Bags (2007)

For laminate films used for packaging bags, we developed a new method of joining films that does not require the use of conventional adhesive tape. A tensile test of the joining area was carried out at various ambient temperatures to examine the joining strength and to compare the fabrication loss with that of the conventional method using adhesive tapes.
Radiation hybrid comparative mapping between human chromosome 17 and porcine chromosome 12 demonstrates conservation of gene order (2001)

A comparative study of human chromosome 17 (HSA17) and pig chromosome 12 (SSC12) was conducted using both somatic cell hybrid panel (SCHP) and radiation hybrid (RH) panel analysis. Sequences from an expressed sequence tag (EST) project in pig reproduction were examined and six genes and ESTs originally believed to map to HSA17 were selected for this study. The genes/ESTs were TATA box binding protein-associated factor (TAF2N/RBP56), alpha-2-plasmin inhibitor (SERPINF2/PLI), H3 histone family 3B (H3F3B), aminopeptidase puromycin sensitive (NPEPPS), an expressed sequence tag (ESTMI015) and P311 protein (P311). The SCHP analysis mapped five genes/ESTs (TAF2N, H3F3B, SERPINF2, NPEPPS and ESTMI015) to SSC12q11-q15 and SSC12p11-p15 with 100% concordance, and assigned P311 to SSC2 (1/2q24)-q29 with 100% concordance. Radiation hybrid analysis of all six genes confirmed the SCHP mapping results, with average retention frequency of 25%. Recent human sequence data demonstrated that P311 is actually located on HSA5q. As HSA5q and SSC2q show conserved syntenic regions predicted from bi-directional painting, our P311 mapping data is consistent with these results. An expanded comparative SSC12 RH map integrating the five new type I markers and 23 previously mapped loci was established using a LOD score threshold of 4.8. The gene order of the five genes/ESTs on the SSC12 framework RH map (H3F3B-ESTMI015-NPEPPS-TAF2N-SERPINF2) is identical to the HSA17 GB4 map but with inversion of the map as conventionally drawn.
Stochastic weight updates in phase-change memory-based synapses and their influence on artificial neural networks (2017)

Artificial neural networks (ANN) have become a<br> powerful tool for machine learning. Resistive memory devices can<br> be used for the realization of a non-von Neumann computational<br> platform for ANN training in an area-efficient way. For instance,<br> the conductance values of phase-change memory (PCM) devices<br> can be used to represent synaptic weights and can be updated<br> in-situ according to learning rules. However, non-ideal device<br> characteristics pose challenges to reach competitive classification<br> accuracies. In this paper, we investigate the impact of granularity<br> and stochasticity associated with the conductance changes on<br> ANN performance. Using a PCM prototype chip fabricated in<br> the 90nm technology node, we present a detailed experimental<br> characterization of the conductance changes. Simulations are<br> done in order to quantify the effect of the experimentally<br> observed conductance change granularity and stochasticity on<br> classification accuracies in a fully connected ANN trained with<br> backpropagation.
Drift Field Implementation in Large Pinned Photodiodes for Improved Charge Transfer Speed (2018)

We present a methodology for generating built-in drift fields in large photodiodes. With the aid of TCAD we demonstrate how non-uniform doping profiles can be implemented in a standard CMOS process using a single additional mask and controlled using the implant conditions and mask geometry. We demonstrate that the resulting doping profile creates a built-in drift field and simulates the effect of the drift field on the charge transfer speed. We show that implementing a drift field can improve charge transfer characteristics of the photodiode.
Growth and characterization of In-polar and N-polar InAlN by metal organic chemical vapor deposition (2010)

In x Al 1 − x N layers, with 0.09≤x≤0.23, were grown on GaN on both the In-polar and N-polar orientations by metal organic chemical vapor deposition. The impact of growth conditions, including temperature and the group-III flow rates, on the surface morphology and indium mole fraction was investigated. In-polar layers had a smooth surface morphology characterized by mounds which decreased in size with increasing supersaturation during growth. Smooth N-polar InAlN was achieved through the use of vicinal sapphire substrates with misorientation angles of 3°–5° toward ⟨101¯0⟩GaN, and a trend of an increase in step bunching with decreasing supersaturation was observed for N-polar InAlN layers. The indium incorporation increased with decreasing growth temperature and increasing growth rate for both In-polar and N-polar layers. The indium incorporation was similar for both orientations on samples which were coloaded in our reactor.
Synthesis, structure, and reactivity of the 2,3- and 3,4-N-phenyl imides and the 3-N-phenyl amide of all-cis-cyclopentane-1,2,3,4-tetracarboxylic acid (2005)

To assess the potential utility of the new amide [(1S,2R,3R,4R)-3-(phenylaminocarbonyl)cyclopentane-1,2,4-tricarboxylic acid] (10) as a pH-sensitive amine-releasing prodrug aimed at selective activation at the low extracellular pH of solid tumours, its reactivity in D 2 O was studied between pD 5 and 6.5. Neighbouring group catalysis of amide hydrolysis by unionised carboxylic acid groups was expected up to neutral pH, with this decreasing with increasing levels of ionisation. Rate measurements on 10 in D 2 O by UV at 27 o C gave k 1 7.3 x 10 -5 s -1 (half-life ca 2.5 h) at pD 5.02 and 3.0 x 10 -5 s -1 (half-life ca 6.5 h) at pD 6.53. However, NMR monitoring of 10 in D 2 O showed that at pD 5 and above, formation of the 2,3-and 3,4-Nphenylimides of cyclopentane-1,2,3,4-tetracarboxylic acid (13 and 16) unexpectedly predominates over amide hydrolysis, thwarting the potential prodrug application. The rates together with variations in the product ratios with pD show that the rate of formation of 13 from 10 is only marginally reduced between pD 5 and 6.5 while the rates of formation of 16 and of hydrolysis products both decrease sharply. We report syntheses of 10 and the new imide 16, Xray crystal structure determinations of imides 13 and 16, as well as NMR data for their solutions in D 2 O at different levels of ionization.
Fault location in underground power networks: A case study (2011)

The present paper addresses the topic of fault location in power networks with cable lines. In the era of smart-grid the demand of intelligent measurement systems capable of providing quickly and with high accuracy the right location of faults in power networks is growing fast. Many proposals can be found in literature relevant to different approaches. Some commercial instrumentation is also available on the market for this purpose. Protection relays implementing this feature can either be found. This paper presents the experimental results of a measurement campaign carried out in the MV power network in the city of Milan (Italy). For this purpose the local Utility (A2A SpA) is using a commercial distributed measurement system (the ALTEA FLS) for locating both faults and also fast transients due to customers' loads operation. Preliminary experimental results have shown good performance. They have been better analyzed in order to investigate over the reliability and the accuracy of such measurement system.
Atomic Force Microscopy Study of Clay Nanoplatelets and Their Impurities (2003)

The results of an in-depth study of 1 nm thick individual clay sheets by atomic force microscopy (AFM) are presented. Several techniques have been employed, including lateral force microscopy (LFM) and force modulation microscopy (FMM). The individual clay sheets, also referred to as clay nanoplatelets in the literature, were found to be extremely compliant and strongly adhered to a variety of substrates. In all cases, these nanoplatelets were accompanied by mobile impurities that could not be separated from the nanoplatelets. A detailed examination of these impurities using AFM suggests that they are comprised of low molecular weight silicates as well as the intercalating salt used to process the clay. An understanding of the nature and chemistry of these impurities will be necessary as models of these clays are developed for various applications, such as reinforcement in composite materials or elements for molecular electronics. Further, these clay nanoplatelets and their impurities present a novel two-dimensional nanoscale system for future surface science studies using AFM and other methods.
Identification of Novel Neutralizing Monoclonal Antibodies against SARS-CoV-2 Spike Glycoprotein (2021)

Coronavirus disease 2019 (COVID-19) is caused by the newly emerged human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to the highly contagious nature of SARS-CoV-2, it has infected more than 137 million individuals and caused more than 2.9 million deaths globally as of April 13, 2021. There is an urgent need to develop effective novel therapeutic strategies to treat or prevent this infection. Toward this goal, we focused on the development of monoclonal antibodies (mAbs) directed against the SARS-CoV-2 spike glycoprotein (SARS-CoV-2 Spike) present on the surface of virus particles as well as virus-infected cells. We isolated anti-SARS-CoV-2 Spike mAbs from animals immunized with a DNA vaccine. We then selected a highly potent set of mAbs against SARS-CoV-2 Spike protein and evaluated each candidate for their expression, target binding affinity, and neutralization potential using complementary ACE2-blocking and pseudovirus neutralization assays. We identified a total of 10 antibodies, which specifically and strongly bound to SARS-CoV-2 Spike, blocked the receptor binding domain (RBD) and angiotensin-converting enzyme 2 (ACE2) interaction, and neutralized SARS-CoV-2. Furthermore, the glycomic profile of the antibodies suggested that they have high Fc-mediated effector functions. These antibodies should be further investigated for elucidating the neutralizing epitopes on Spike for the design of next-generation vaccines and for their potential in diagnostic as well as therapeutic utilities against SARS-CoV-2.
Antibiofilm Peptides Increase the Susceptibility of Carbapenemase-Producing Klebsiella pneumoniae Clinical Isolates to β-Lactam Antibiotics (2015)

Multidrug-resistant carbapenemase-producing Klebsiella pneumoniae (KpC) strains are becoming a common cause of infections in health care centers. Furthermore, Klebsiella can develop multicellular biofilms, which lead to elevated adaptive antibiotic resistance. Here, we describe the antimicrobial and antibiofilm activities of synthetic peptides DJK-5, DJK-6, and 1018 against five KpC isolates. Using static microplate assays, it was observed that the concentration required to prevent biofilm formation by these clinical isolates was below the MIC for planktonic cells. More-sophisticated flow cell experiments confirmed the antibiofilm activity of the peptides against 2-day-old biofilms of different KpC isolates, and in some cases, the peptides induced significant biofilm cell death. Clinically relevant combinations of DJK-6 and β-lactam antibiotics, including the carbapenem meropenem, also prevented planktonic growth and biofilm formation of KpC strain1825971. Interestingly, peptide DJK-6 was able to enhance, at least 16-fold, the ability of meropenem to eradicate preformed biofilms formed by this strain. Using peptide DJK-6 to potentiate the activity of β-lactams, including meropenem, represents a promising strategy to treat infections caused by KpC isolates.
Tools to study development, aging and genetics of intersubject variability in cortical morphology (2011)

National audience
Immunotherapy and the Interventional Oncologist: Challenges and Opportunities—A Society of Interventional Oncology White Paper (2019)

Interventional oncology is a subspecialty field of interventional radiology that addresses the diagnosis and treatment of cancer and cancer-related problems by using targeted minimally invasive procedures performed with image guidance. Immuno-oncology is an innovative area of cancer research and practice that seeks to help the patient's own immune system fight cancer. Both interventional oncology and immuno-oncology can potentially play a pivotal role in cancer management plans when used alongside medical, surgical, and radiation oncology in the care of cancer patients.
Mechanisms for Chemical Vapor Deposition Carbon Nanotube Growth by Surface Modification of 316L Stainless Steel (2023)

Journal Article Mechanisms for Chemical Vapor Deposition Carbon Nanotube Growth by Surface Modification of 316L Stainless Steel Get access Joshua Hancock, Joshua Hancock Department of Physics, Brigham Young University, Provo, UT, United States Search for other works by this author on: Oxford Academic Google Scholar Felipe Rivera, Felipe Rivera Department of Physics, Brigham Young University, Provo, UT, United StatesElectron Microscopy Facility, Brigham Young University, Provo, UT, United States Search for other works by this author on: Oxford Academic Google Scholar Brian Jensen, Brian Jensen Department of Mechanical Engineering, Brigham Young University, Provo, UT, United States Search for other works by this author on: Oxford Academic Google Scholar Richard Vanfleet Richard Vanfleet Department of Physics, Brigham Young University, Provo, UT, United States Corresponding author: richard_vanfleet@byu.edu Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 29, Issue Supplement_1, 1 August 2023, Pages 759–761, https://doi.org/10.1093/micmic/ozad067.375 Published: 22 July 2023
Unexpected role of SIX1 variants in craniosynostosis: expanding the phenotype of SIX1-related disorders (2021)

Craniosynostosis is associated with heterozygous <i>SIX1</i> variants, with possible enrichment of loss-of-function variants compared with classical BOS. We recommend screening of <i>SIX1</i> in craniosynostosis, particularly when sagittal±lambdoid synostosis and/or any BOS phenotypes are present. These findings highlight the role of <i>SIX1</i> in cranial suture homeostasis.
Lable-free biosensor based on localized surface plasmon resonance in a multi-channel microfluidic chip (2009)

A label-free biosensor based on localized surface plasmon resonance (LSPR) was developed. A multi-channel microfluidic chip was integrated with the sensor, providing referencing channel to minimize noise level and improving the throughput. With a CCD as a detector, a sensitivity of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> RIU was demonstrated. The adsorption of S-layer protein was detected successfully by the sensor system.
Persistent Infection of Human Oligodendrocytic and Neuroglial Cell Lines by Human Coronavirus 229E (1999)

Human coronaviruses (HuCV) cause common colds. Previous reports suggest that these infectious agents may be neurotropic in humans, as they are for some mammals. With the long-term aim of providing experimental evidence for the neurotropism of HuCV and the establishment of persistent infections in the nervous system, we have evaluated the susceptibility of various human neural cell lines to acute and persistent infection by HuCV-229E. Viral antigen, infectious virus progeny and viral RNA were monitored during both acute and persistent infections. The astrocytoma cell lines U-87 MG, U-373 MG, and GL-15, as well as neuroblastoma SK-N-SH, neuroglioma H4, and oligodendrocytic MO3.13 cell lines, were all susceptible to an acute infection by HuCV-229E. The CHME-5 immortalized fetal microglial cell line was not susceptible to infection by this virus. The MO3.13 and H4 cell lines also sustained a persistent viral infection, as monitored by detection of viral antigen and infectious virus progeny. Sequencing of the S1 gene from viral RNA after approximately 130 days of infection showed two point mutations, suggesting amino acid changes during persistent infection of MO3.13 cells but none for H4 cells. Thus, persistent in vitro infection did not generate important changes in the S1 portion of the viral spike protein, which was shown for murine coronaviruses to bear hypervariable domains and to interact with cellular receptor. These results are consistent with the potential persistence of HuCV-229E in cells of the human nervous system, such as oligodendrocytes and possibly neurons, and the virus's apparent genomic stability.
Cisplatin-based chemotherapy for postoperative recurrence in non-small cell lung cancer patients: Relation of the in vitro chemosensitive test to clinical response (2001)

The usefulness of the in vitro chemosensitivity test, the collagen gel droplet embedded culture drug- sensitivity test (CD-DST, Int J Oncol 11: 449, 1997), in cisplatin-based combined chemotherapy for postoperative recurrent tumors in non-small cell lung cancer (NSCLC) patients was retrospectively analyzed. CD-DST data for cisplatin (or carboplatin), etoposide, 5-fluorouracil, mitomycin C, and vindesine were obtained in 311 surgically resected primary lesions. Of them, 25 patients were practically treated with first-line cisplatin- or carboplatin-based chemotherapy for postoperative initial recurrence. Nine (36%) of them responded to the combined chemotherapy for recurrent lesions, including one with complete remission, whereas 16 did not, with no change in 5 and progression in 11. Seven (70%) of 10 patients receiving combined chemotherapy using two or three in vitro sensitive chemoagents showed good responses, whereas there was no responder among the patients receiving chemotherapy including no in vitro sensitive chemoagents. In particular, of 11 patients showing good sensitivity to cisplatin or carboplatin on CD-DST, 8 (73%) responded to chemotherapy, whereas only one (7%) of 14 patients showing cisplatin- or carboplatin-resistance on CD-DST was a responder. Thus, CD-DST results for the chemoagents, especially cisplatin or carboplatin, correlated with chemotherapeutic response, indicating that the CD-DST analysis of surgically resected primary NSCLC tumors is a practically useful indicator of the clinical effect of first-line cisplatin-based combined chemotherapy for postoperative recurrence.