gebhart/patrepeval huggingface dataset:
Job Placement Advisor Based on Turnaround Predictions for HPC Hybrid\n Clouds (2016)

Several companies and research institutes are moving their CPU-intensive\napplications to hybrid High Performance Computing (HPC) cloud environments.\nSuch a shift depends on the creation of software systems that help users decide\nwhere a job should be placed considering execution time and queue wait time to\naccess on-premise clusters. Relying blindly on turnaround prediction techniques\nwill affect negatively response times inside HPC cloud environments. This paper\nintroduces a tool to make job placement decisions in HPC hybrid cloud\nenvironments taking into account the inaccuracy of execution and waiting time\npredictions. We used job traces from real supercomputing centers to run our\nexperiments, and compared the performance between environments using real\nspeedup curves. We also extended a state-of-the-art machine learning based\npredictor to work with data from the cluster scheduler. Our main findings are:\n(i) depending on workload characteristics, there is a turning point where\npredictions should be disregarded in favor of a more conservative decision to\nminimize job turnaround times and (ii) scheduler data plays a key role in\nimproving predictions generated with machine learning using job trace\ndata---our experiments showed around 20% prediction accuracy improvements.\n
Nuclear Receptors as Targets for Drug Development: The Role of Nuclear Receptors During Neural Stem Cell Proliferation and Differentiation (2005)

The fate of stem cells, such as neural stem cells and hematopoietic stem cells, depends on strictly regulated signaling events including activation of nuclear receptors, resulting in subsequent gene induction. Recently, we demonstrated that PPARgamma, a ligand-activated nuclear receptor, plays an important role in regulating the proliferation and differentiation of murine neural stem cell (NSC). NSC prepared from heterozygous PPARgamma-deficient mouse exhibited a slower growth rate compared with that of wild-type mouse, which was also demonstrated in PPARgamma-knockdown NSC that was generated by the lentiviral-vector-mediated RNA interference approach. These studies have important implications for understanding central nervous system functions and developing a therapy for neurodegenerative disorders. In this review, recent findings on stem cell biology, especially focusing on nuclear receptors in NSCs, including our current study, will be discussed.
Mixed Meal and Intravenous L-Arginine Tests Both Stimulate Incretin Release Across Glucose Tolerance in Man: Lack of Correlation with β Cell Function (2018)

Both MMTT and AST resulted in insulin and enteroendocrine hormone responses across GT populations without consistent correlation between release of incretins and insulin, which is in line with other published research. If a defect is in the enteroendocrine/β cell axis, it is probably reduced response to rather than diminished secretion of enteroendocrine hormones.
Very Low Birth Weight Infants in Germany: How many Therapies Do They Get until Preschool Age? (2015)

Aims: Very low birth weight infants (birth weight < 1,500 g; VLBW) have an increased risk for developmental delays. There are few data whether and which kind of therapy these VLBW infants receive during the infancy.
Domino Syntheses of Bioactive Tetronic and Tetramic Acids (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Exploring Ramachandran and Chi Space: Conformationally Constrained Amino Acids and Peptides in the Design of Bioactive Polypeptide Ligands (2004)

Ligand binding and concomitant changes in receptor structure provide the means to target signal transduction pathways. With appropriate refinement of the ligand's interaction with the "receptor," one in theory could produce ligands that have greater therapeutic benefits. This review will discuss how, when these ligands are amino acids and peptides, the introduction of appropriate conformational constraints provides a powerful strategy for improved drug design. This review will discuss how various constraints on amino acids can provide a powerful tool for ligand design, determination of the three dimensional pharmacophore and new insights into receptor systems and information transduction. Through the use of constrained ligands, new information regarding their interaction with their "receptor" systems, and further refinement of the use of constraints, scientists can produce more beneficial drugs for mankind.
Stimulation of the pelvic nerve increases bladder capacity in the prostaglandin E2 rat model of overactive bladder (2017)

Overactive bladder (OAB) syndrome is a highly prevalent condition that may lead to medical complications and decreased quality of life. Emerging therapies focusing on selective electrical stimulation of peripheral nerves associated with lower urinary tract function may provide improved efficacy and reduced side effects compared with sacral neuromodulation for the treatment of OAB symptoms. Prior studies investigating the effects of pelvic nerve (PelN) stimulation on lower urinary tract function were focused on promoting bladder contractions, and it is unclear whether selective stimulation of the PelN would be beneficial for the treatment of OAB. Therefore our motivation was to test the hypothesis that PelN stimulation would increase bladder capacity in the prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) rat model of OAB. Cystometry experiments were conducted in 17 urethane-anesthetized female Sprague-Dawley rats. The effects of intravesical PGE<sub>2</sub> vs. vehicle and PelN stimulation after intravesical PGE<sub>2</sub> on cystometric parameters were quantified. Intravesical infusion of PGE<sub>2</sub> resulted in decreased bladder capacity and increased voiding efficiency without a change in bladder contraction area under the curve, maximum contraction pressure, or contraction duration. Bladder capacity was also significantly decreased compared with vehicle (1% ethanol in saline) confirming that the change in bladder capacity was mediated by PGE<sub>2</sub> PelN stimulation reversed the PGE<sub>2</sub>-induced change in bladder capacity and increased the external urethral sphincter electromyogram activity at a specific stimulation condition (amplitude of 1.0 times threshold at 10 Hz). These results confirm that the urodynamic changes reported in conscious rats are also observed under urethane anesthesia and that PelN stimulation is a novel and promising approach for the treatment of the symptoms of OAB.
Cationic actinide metallocene alkyls and hydrides. Metal bis(dicarbollides) as counterions (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleCationic actinide metallocene alkyls and hydrides. Metal bis(dicarbollides) as counterionsXinmin Yang, Wayne A. King, Michal Sabat, and Tobin J. MarksCite this: Organometallics 1993, 12, 10, 4254–4258Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://pubs.acs.org/doi/10.1021/om00034a079https://doi.org/10.1021/om00034a079research-articleACS PublicationsRequest reuse permissionsArticle Views166Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Synthesis and reactions of brominated 2-nitroimidazoles (1989)

Various approaches to the synthesis of the hitherto-unknown 4(5)-bromo-2-nitroimidazole (5) are reported. Direct bromination of 2-nitroimidazole with N-bromosuccinimide gave the unreported 4,5-dibromo-2-nitroimidazole (10) in quantitative yield, but this could not be selectively debrominated to give compound (5). While 1-methyl-2-nitroimidazole readily gave 4-bromo-1-methyl-2-nitroimidazole (15) on bromination, this could not be demethylated to give (5), and bromination of various other N-protected 2-nitroimidazoles was also unsuccessful. Lithiation of 4-bromo-1-tritylimidazole (21) followed by quenching with propyl nitrate gave (after detritylation and methylation) a mixture of a dimer (28) and compound (15), indicating that the desired product (5) is produced in this reaction although it can only be isolated in derivatized form. The proposed route for formation of the dimer suggests a general reaction between 1-alkyl-4-bromo-2-nitroimidazoles and strong C- and N-nucleophiles, resulting in substitution at the 5-position.
Human CD90 Identifies Th17/Tc17 T Cell Subsets That Are Depleted in HIV-Infected Patients (2011)

By revisiting CD90, a GPI-anchored glycoprotein, we show that CD90 is expressed by a subset of CD4(+) and CD8(+) human T cells. CD4(+)CD90(+) cells share similarities with Th17 cells because they express the Th17-specific transcription factor RORC2 and produce IL-17A. CD4(+)CD90(+) cells are activated memory T cells that express the gut mucosal markers CCR6, CD161, and the α(4) and β(7) integrins. Compared with CD90-depleted CCR6(+) memory Th17 cells, CD4(+)CD90(+) cells express higher levels of IL-22 and proinflammatory cytokines (IL-6, TNF-α and GM-CSF), but they produce lower levels of IL-21 and no IL-9. Analyses of CD8(+)CD90(+) cells reveal that they express RORC2 and are able to produce higher levels of IL-17A, IL-22, and CCL20 compared with CD90-depleted CD8(+) cells. These data show that CD90 identifies Th17 and Tc17 cells with a peculiar cytokine profile. Studies of circulating CD90(+) cells in HIV patients show that CD90(+) cells are decreased with an imbalance of the CD4(+)CD90(+)/regulatory T cell ratio in nontreated patients compared with treated patients and healthy donors. Overall, human CD90 identifies a subset of Th17 and Tc17 cells within CD4(+) and CD8(+) T cells, respectively, which are depleted during HIV infection.
Supplemental data Figure 4 from Preclinical Characterization of SGN-70, a Humanized Antibody Directed against CD70 (2023)

Supplemental data Figure 4 from Preclinical Characterization of SGN-70, a Humanized Antibody Directed against CD70
ChemInform Abstract: Singlet Oxygen Oxidation of Substituted Furans to 5‐Hydroxy‐2(5H)‐ furanone. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Oxime Carbapalladacycle Covalently Anchored to High Surface Area Inorganic Supports or Polymers as Heterogeneous Green Catalysts for the Suzuki Reaction in Water. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
PSMNet: Position-aware Stereo Merging Network for Room Layout Estimation (2022)

In this paper, we propose a new deep learning-based method for estimating room layout given a pair of 360 panoramas. Our system, called Position-aware Stereo Merging Network or PSMNet, is an end-to-end joint layout-pose estimator. PSMNet consists of a Stereo Pano Pose (SP2) transformer and a novel Cross-Perspective Projection (CP2) layer. The stereo-view SP2 transformer is used to implicitly infer correspondences between views, and can handle noisy poses. The pose-aware CP2 layer is designed to render features from the adjacent view to the anchor (reference) view, in order to perform view fusion and estimate the visible layout. Our experiments and analysis validate our method, which significantly outperforms the state-of-the-art layout estimators, especially for large and complex room spaces.
Efficacy of platinum chemotherapy agents in the adjuvant setting for adenosquamous carcinoma of the pancreas. (2014)

269 Background: Pancreatic adenosquamous carcinoma (PASC) accounts for only 1-4% of exocrine pancreatic cancers and carries a particularly poor prognosis. This retrospective study was performed to determine whether inclusion of a platinum agent as part of adjuvant therapy is associated with improved survival in patients with PASC. Methods: Records of all patients who underwent pancreatic resection at our institution from 1986-2012 were reviewed to identify those with PASC. Multivariable Cox proportional hazards modeling was used to assess for significant associations between patient characteristics and survival. Results: In total, 62 patients with PASC were identified among 5,627 cases (1.1%). Median age was 68 (interquartile range [IQR], 57-77) and 44% were female. Multivariate analysis revealed that among all patients (n=62) the following factors were independently predictive of survival: lack of adjuvant therapy (hazard ratio [HR]=3.558, p=0.0002), positive margin (HR=3.466, p=0.0003), lymph node involvement (HR=3.482, p=0.004), and age (HR=1.030, p=0.035). Among patients who underwent adjuvant therapy (n=39), those who received a platinum agent as part of the adjuvant therapy regimen experienced a longer median survival of 19.1 months (95% CI, 13.8-24.4) compared to 10.7 months (95% CI, 7.9-13.5) for patients who never received a platinum agent (p=0.011, log-rank test). Given this improvement in survival on univariate analysis, a second multivariable model was constructed to elucidate factors associated with survival among patients who received adjuvant therapy in order to confirm the univariate result while controlling for potential confounding risk factors. Backward elimination performed using this second multivariable model revealed that inclusion of a platinum agent in the adjuvant regimen (median survival HR=0.408, p=0.040) and larger tumor diameter (HR=1.259, p=0.047) were independent predictors of survival for this cohort. Conclusions: Addition of a platinum agent to adjuvant regimens for resected PASC should be considered as a means to improve survival among these high risk patients, though collaborative prospective investigation is needed.
Facile Protection of Lithium Metal for All‐Solid‐State Batteries (2019)

A nanolayer of reactive propyl acrylate silane groups was deposited on a lithium surface by using a simple dipping method. The polymerization of cross-linkable silane groups with a layer of ally-ether-ramified polyethylene oxide was induced by UV light. SEM analysis revealed a good dispersion of silane groups grafted on the lithium surface and a layer of polymer of about 4 μm was obtained after casting and reticulation. The electrochemical performance for the unmodified and modified lithium electrodes were compared in symmetrical Li/LLZO/Li cells. Stable plating/stripping and low interfacial resistance were obtained when the modified lithium was utilized, indicating that the combination of silane and polymer deposition is promising to increase Li-metal/garnet contact.
A Methodology to Emulate the Effect of EMI in Circuit Simulators for Wireline Communication Channel (2021)

This letter presents a methodology to model the effect of electromagnetic interference (EMI) on the wireline communication channels. The proposed simulation methodology incorporates the effect of EMI on the circuit during the design phase in EMI-sensitive applications. It allows simple and faster EMI simulations at the SPICE level which minimizes the post-fabrication failures. A TEM (transverse electromagnetic) cell is used to emulate the effect of EMI on the test circuit as provided in the standard IEC-62132. An analytical model is presented to quantify the effect of induced voltage and current on a transmission line placed in the TEM cell. The developed model is experimentally verified for a frequency range of 1 MHz to 1 GHz. As an experimental study, the proposed model is used to validate the effect of EMI on the wireline communication channel transmitting a pseudorandom binary sequence (PRBS) data generated from an FPGA board at 1 Gbps data rate for a wide range of EMI powers and frequencies.
Elliptical-core dual-mode fiber dispersion compensator (1993)

Chromatic dispersion compensation is demonstrated in a 2.5-Gb/s system experiment using an elliptical-core dual-mode fiber operated in the LP/sub 11/ mode near cutoff. With a measured dispersion of -548 ps/nm-km for the LP/sub 11/ mode and a novel double-pass configuration, complete compensation of the dispersion in 50 km of conventional single-mode fiber at 1530 nm is achieved with 0.72 km of dual-mode fiber. System degradation due to remnant LP/sub 01/ mode power in the dual-mode fiber is investigated and found to be small for relative LP/sub 01/ power levels less than -20 dB.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Novel Assessment of Factor VIII Activity by Template Matching Utilizing Weighted Average Parameters from Comprehensive Clot Waveform Analysis (2020)

This novel algorithm based on weighted averages of aPTT-based waveforms together with template-matching may support clinical usefulness for judging of HA and may aid clinical management in the patients in the absence of specific clotting factor assays.
Defect Structure of Mg-Doped GaN Nanowires (2003)

With a large direct energy gap, GaN is a promising candidate for blue and ultraviolet light emitters. Quasi one-dimensional GaN nanowires may find application in optoelectrical devices and are interesting for fundamental research. p-n junctions have recently been developed in GaN nanowires by first growing n-type nanowires and then subsequently continuing the growth in an environment to realize p-type material (via Mg-doping) In this work we have thoroughly examined thin Mg-doped GaN nanowires as well as the unintentionally-doped ones. It has been found that doped nanowires show a high density of stacking faults when the diameter is less than 22nm. It is interesting that these defective structures are rarely observed in the unintentionally-doped GaN nanowires or in nanowires with larger diameters.
Microcavity interferometry for MEMS device characterization (2003)

We have developed a high resolution optical technique to measure the electromechanical properties of MEMS microstructures. The technique is applied to microbridges developed for capacitive switching in coplanar radio frequency (RF) waveguides. The thin metal ground plane on the substrate and the bottom of the bridge together form a microcavity for an optical beam. The wavelength of a cavity mode is a sensitive measure of the bridge position relative to the substrate. The technique is applied to the measurement of resonances and damping times of microbridges of varying lengths. It is also used to measure dc changes in bridge height of tenths of nanometers, driven ac displacements of less than a picometer, and bridge displacement noise of hundreds of femtometers per root Hertz. This extreme sensitivity exceeds previously demonstrated optical characterization methods.
Vertical-cavity surface-emitting-lasers with 21% efficiency by metalorganic vapor phase epitaxy (2002)

We have demonstrated vertical-cavity top-surface-emitting InGaAs QW lasers by metalorganic vapor phase epitaxy that set record cw performance marks of 21% power conversion efficiency, 1.47 V threshold voltage, 23 mW output power, and 3.7 mW single-mode output power. The enhanced laser performance relies on novel mirror designs and benefits of metalorganic vapor phase epitaxy.
Optimal Priority Assignment for Scheduling Mixed CAN and CAN-FD Frames (2019)

Controller Area Network with Flexible Data-rate (CAN-FD) has been drawing considerable attention as the most promising substitute of Controller Area Network (CAN), thanks to its higher bandwidth, larger payload size, and physical-layer compatibility with CAN. In particular, the physical-layer compatibility allows legacy CAN-based Electronic Control Units (ECUs) to share the same communication bus with CAN-FD-based ECUs. However, CAN-based ECUs always treat a CAN-FD frame as an erroneous frame due to the difference in frame format. This, in turn, makes CAN-FD-based ECUs unable to communicate with each other via CAN-FD frames. A straightforward solution to this problem is to utilize the silent mode of the current CAN controller, in which a CAN node does not transmit any frame including error frames, but can receive CAN frames. However, a non-negligible time overhead is incurred by each mode transition, thus degrading the schedulability of mixed CAN and CAN-FD frame sets significantly. We propose a new algorithm, called Priority Assignment with Mode Transition (PAMT), that minimizes the required number of mode transitions by clustering frame instances based on their frame type. Our evaluation results show that PAMT can schedule about 17% more mixed CAN and CAN-FD frame sets than existing optimal priority assignment algorithms for CAN.
Reduced CDHR3 expression in children wheezing with rhinovirus (2018)

Preschool children with RV-induced wheezing were shown to have reduced CDHR3 mRNA levels, which might result in an increased permeability of the epithelial layers of the airways and thereby an increased vulnerability. Thus, measuring CDHR3 mRNA levels might help to identify a more severe phenotype of wheezing preschool children.
Observational cohort study of IP-10’s potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19 (2021)

Clinicaltrials.gov, NCT04389645, retrospectively registered on May 15, 2020.
Round robin tests on laser ablation and quantitative analysis by LIBS (2016)

International audience