gebhart/patrepeval huggingface dataset:
UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development (2012)

UTX (KDM6A) and UTY are homologous X and Y chromosome members of the Histone H3 Lysine 27 (H3K27) demethylase gene family. UTX can demethylate H3K27; however, in vitro assays suggest that human UTY has lost enzymatic activity due to sequence divergence. We produced mouse mutations in both Utx and Uty. Homozygous Utx mutant female embryos are mid-gestational lethal with defects in neural tube, yolk sac, and cardiac development. We demonstrate that mouse UTY is devoid of in vivo demethylase activity, so hemizygous X(Utx-) Y(+) mutant male embryos should phenocopy homozygous X(Utx-) X(Utx-) females. However, X(Utx-) Y(+) mutant male embryos develop to term; although runted, approximately 25% survive postnatally reaching adulthood. Hemizygous X(+) Y(Uty-) mutant males are viable. In contrast, compound hemizygous X(Utx-) Y(Uty-) males phenocopy homozygous X(Utx-) X(Utx-) females. Therefore, despite divergence of UTX and UTY in catalyzing H3K27 demethylation, they maintain functional redundancy during embryonic development. Our data suggest that UTX and UTY are able to regulate gene activity through demethylase independent mechanisms. We conclude that UTX H3K27 demethylation is non-essential for embryonic viability.
Model studies for the mechanism of inactivation of monoamine oxidase by 5-(aminomethyl)-3-aryl-2-oxazolidinones (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModel studies for the mechanism of inactivation of monoamine oxidase by 5-(aminomethyl)-3-aryl-2-oxazolidinonesKent S. Gates and Richard B. SilvermanCite this: J. Am. Chem. Soc. 1989, 111, 24, 8891–8895Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://doi.org/10.1021/ja00206a018RIGHTS & PERMISSIONSArticle Views138Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (631 KB) Get e-Alerts Get e-Alerts
P-STT-MRAM thermal stability and modeling of its temperature dependence (2018)

Due to their high speed[1], high endurance[2] and non-volatility, perpendicular STT-MRAM (P-STT-MRAM) are seen as one of the best candidate for non volatile memory embedded applications. However, their data retention time at elevated temperature such as the soldering reflow criterion and the automotive application temperature range is still a critical point. In this paper, P-STT-MRAM devices with diameters ranging from 20nm to 150nm have been tested in temperature. The thermal stability factor has been extracted electrically for temperatures up to 190°C. Then the loss in the Curie temperature of the storage layer compared to bulk values has been measured and directly linked to the thermal stability values. At last, a model is proposed to predict the temperature dependance of the thermal stability factor.
The secretome of adipose-derived mesenchymal stem cells attenuates epithelial–mesenchymal transition in human corneal epithelium (2019)

The secretome of AdMSCs can inhibit TGF-β-induced EMT in CECs. These findings suggest that this could be a useful source for the treatment for EMT-related ocular surface diseases.
Statistical Molecular Design, Parallel Synthesis, and Biological Evaluation of a Library of Thrombin Inhibitors (2001)

A library of thrombin inhibitors has been designed using statistical molecular design. An aromatic scaffold was used, with three varied positions corresponding to three pockets at the active site of thrombin (the S-, P-, and D-pockets). The selection was performed in the building block space, and previously acquired data were included in the design procedure. The design resulted in six, four, and six building blocks for the first (S), second (P), and third (D) pockets, respectively. A second round of selection applied to the combined selected building blocks resulted in a subset of 18 compounds. The selected library was synthesized in parallel and biologically evaluated. The compounds were analyzed with respect to their inhibition (pIC(50)) of thrombin; membrane permeability, estimated by migration behavior in micellar media (CE log k') and pK(a); and specificity with respect to inhibition (K(i)) of trypsin. Multivariate QSAR studies of the responses yielded valuable results and information that could only be found using statistical molecular design in combination with multivariate analysis.
Effect of ammonium chloride on the bicarbonate buffer system in heat‐stressed broilers (1989)

1. The effects of ammonium chloride (NH4Cl) on the bicarbonate buffer system and plasma lactate in heat-stressed broilers were investigated. 2. The infusion of a 10 g/l solution of NH4Cl into the crop during a 90 min thermoneutral period produced a metabolic acidosis resulting from a reduction in blood bicarbonate concentration. Blood bicarbonate continued to decrease in NH4Cl-treated birds and reached values which were 30% of controls by the end of a 90 min heat stress period. 3. By the end of heat stress, plasma lactate concentrations were lower in NH4Cl-infused birds than in controls.
Theoretical and Experimental Development of an Array of Droopy Bowties with Integrated Baluns (2014)

"Theoretical modeling, design, assembly, and measurement of a novel integrated phased array radiator are presented. The droopy bowtie turnstile radiator with quad line feed meets challenging radar requirements and uses low cost manufacturing and assembly techniques. This thesis develops the complete theoretical model (antenna, balun, feeding network) of a broadband phased array radiator: the droopy bowtie turnstile radiator. A novel quad line balun feed is developed that provides a low loss, high isolation, and coincident phase-center feeding network for the droopy bowtie. The radiator and feed design combines broadband RF performance and high-isolation dual-linear polarization in a low profile, compact package that enables wide scan volume performance versus frequency. This thesis develops low-cost manufacturing and assembly techniques applied to the droopy bowtie radiator with the quad line feed. The new radiator design would utilize low cost fabrication techniques such as injection molding and 3-D printing, and also leverages automated assembly techniques. Measurement prototypes and array prototypes of droopy bowtie radiators with the quad line feed are developed for L- and X-bands. The measurements demonstrate broadband RF performance in a low profile compact package viable for wide-scale phased array applications."
Langzeitstabile und hoch regioselektive “Supported‐Ionic‐Liquid‐Phase(SILP)”‐Katalysatoren: Kontinuierliche Hydroformylierung von Propen im Festbettreaktor (2004)

Die Vorteile der klassischen Heterogenkatalyse und der Übergangsmetallkatalyse in ionischen Flüssigkeiten vereinen aktive und hoch selektive Rhodium-Bisphosphan-Katalysatoren in ionischen Flüssigkeiten, die auf Siliciumoxidträgern immobilisiert vorliegen. Diese langzeitstabilen und hoch regioselektiven Katalysatoren wurden in der kontinuierlichen Gasphasenhydroformylierung von Propen eingesetzt. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2005/z461534_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Simulation and Implementation of Distributed Microwave Wireless Power Transfer System (2022)

Recently, microwave power transfer (MPT) for Internet-of-Things (IoT) devices has been actively studied. The distributed microwave power transfer (DMPT) can supply power efficiently by cooperating multiple transmit antenna arranged distributed in a relatively wide area. In this article, the advantages of DMPT are shown by using ray-trace-based Monte Carlo simulation. In addition, an algorithm for optimizing the phase is proposed and discussed its convergence. Furthermore, the implementation of DMPT using a backscatter-based closed-loop system is proposed. The system was built using the open-source platform GNU Radio. Experimental results show the effectiveness of the proposed system.
Influenza B viruses from different genetic backgrounds are variably impaired by neuraminidase inhibitor resistance–associated substitutions (2019)

Identifying evolutionary routes to antiviral resistance among influenza viruses informs molecular-based resistance surveillance and clinical decisions. To improve antiviral management and understand whether clinically identified neuraminidase (NA) inhibitor (NAI) resistance-associated markers affect influenza B viruses of the Victoria- or Yamagata-lineages differentially, we generated a panel of NAI-resistant viruses (carrying E105K, G145E, R150K, D197N, I221 L/N/T/V, H273Y, N294S, or G407S substitutions; B numbering) in B/Brisbane/60/2008 (BR/08) and B/Phuket/3073/2013 (PH/13). In both backgrounds, I221 L/N/T/V resulted in reduced or highly reduced inhibition (HRI) by one to three currently available NAIs. D197N reduced inhibition by all NAIs in BR/08 but only by oseltamivir and peramivir in PH/13; R150K caused HRI by all NAIs in PH/13. Although PH/13 generally retained or enhanced NA activity in the presence of the substitutions, enzymatic activity in BR/08 was detrimentally affected. Similarly, substrate affinity and catalysis were relatively stable in PH/13, but not in the BR/08 variants. E105K, R150K, and D197N attenuated replication efficiency of BR/08 in vitro and in mice; only E105K had this effect in PH/13. Notably, the I221 L/N/T/V substitutions did not severely impair replication, particularly in PH/13. Overall, our data show differential effects of NA substitutions in representative Victoria- and Yamagata-lineage viruses, suggesting distinct evolution of these viruses caused variable fitness and NAI susceptibility profiles when similar key NA substitutions arise. Because the viruses harboring the I221 NA substitutions displayed undiminished fitness and are commonly reported, this position is likely to be the most clinically relevant marker for NAI resistance among contemporary influenza B viruses.
Resonant enhancement of semiconductor laser modulation response for efficient analog transmission at 35 GHz (1993)

We investigate the characteristics of directly modulated semiconductor lasers with external cavity using 35 GHz sub carrier. We have achieved bit error rates 10<SUP>-9</SUP> for data transmission over short optical fiber links with a binary phase shift keying modulation of 35 GHz sub carrier.
Pharmacodynamic Characterization of the Efficacy Signals Due to Selective BRAF Inhibition with PLX4032 in Malignant Melanoma (2010)

PLX4032 has robust activity in BRAF mutated melanoma. The preclinical use of this molecule identifies criteria for its proper clinical application, describes patterns of and reasons for response/resistance, and affords insight into the role of a BRAF mutation in melanoma.
ADrosophilaribosomal protein gene is located near repeated sequences including rDNA sequences (1982)

We have isolated a cloned segment of Drosophila genomic DNA containing a ribosomal protein gene. Hybridization analysis of the DNA in this clone indicates a complex organization of repeated elements within this cloned segment. At least one of these repeated elements is homologous to regions of rDNA. Restriction analysis of the clone shows that some of the repeated elements are present as tandem duplications and in scattered locations within the cloned DNA segment. There are also three non-ribosomal protein genes contained in this clone, each of which is expressed along with the ribosomal protein gene into RNA species present in Drosophila embryos.
173: Tissue Bioreactor System for the Creation and Maturation of Organized Functional Tissues for Surgical Reconstruction (2007)

You have accessJournal of UrologyModerated Poster 7, Sunday, May 20, 2007, 8:00 - 10:00 am1 Apr 2007173: Tissue Bioreactor System for the Creation and Maturation of Organized Functional Tissues for Surgical Reconstruction Du Geon Moon, George J. Christ, Joel Stitzel, James J. Yoo, and Anthony Atala Du Geon MoonDu Geon Moon More articles by this author , George J. ChristGeorge J. Christ More articles by this author , Joel StitzelJoel Stitzel More articles by this author , James J. YooJames J. Yoo More articles by this author , and Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30438-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "173: Tissue Bioreactor System for the Creation and Maturation of Organized Functional Tissues for Surgical Reconstruction." The Journal of Urology, 177(4S), pp. 58–59 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 58-59 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Du Geon Moon More articles by this author George J. Christ More articles by this author Joel Stitzel More articles by this author James J. Yoo More articles by this author Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Fabrication of an Al Foam/Dense Steel Composite by Friction Welding (2013)

Al foam is lightweight with superior shock-absorbing properties but has low tensile and bending strengths. This has spurred efforts to form composites of Al foam with dense materials. In this study, we examined the possibility of fabricating composite structures of Al foam and dense steel with strong metal bonding by employing friction welding. The use of friction welding is expected to facilitate the fabrication of Al foam/dense steel composites by a simple process with low environmental impact. It is shown that this procedure is capable of fabricating an Al foam/dense steel composite in which the Al foam completely fills the hollow in the dense steel. An Fe–Al intermetallic compound (IMC) layer with a thickness on the order of 10 µm was found throughout almost the entire interface between the Al foam and the dense steel. Therefore, it is shown that an Al foam/dense steel composite with strong metal bonding can be fabricated.
Evaluation of denaturing conditions in analysis of DNA variants applied to multi‐capillary electrophoresis instruments (2003)

Abstract Denaturant slab gel techniques (DGGE and variants thereof) and denaturing CE (DCE) have been used for the analysis of mutations and single nucleotide polymorphisms by several research groups. Recently, DCE applied to commercially available capillary electrophoresis instruments has been demonstrated to be sensitive, specific, and robust for mutation and SNP analysis. However, instruments currently available on the market are not designed for DCE in their present forms. In both single and multi‐capillary instruments inaccurate temperature control units lead to irreproducible denaturing conditions, both between runs and from capillary to capillary within an electrophoresis run. We have previously suggested that cycling a temperature gradient several times around a theoretically defined optimum for a given DNA fragment results in more reproducible and controllable denaturing conditions compared to a constant denaturant or single sweep temperature gradient. In this paper, we demonstrate that with the temperature differences observed, the common technique of applying a temperature gradient is not sufficient for optimal separation conditions in all capillaries. Furthermore, we demonstrate that cycling of the temperature around a fragment's theoretically calculated melting temperature during electrophoresis leads to reproducible results in all capillaries. These results clearly show the potential of standard commercial capillary instruments in automated cycling temperature CE applications.
The Discovery of a New Organic Nitrate (1995)

Organic nitrates have been in therapeutic use for the treatment of angina pectoris for over a century. During the past decade, the search for new organic nitro esters with reduced side effects and improved oral bioavailability has been greatly intensified. We have discovered a new class of organic nitrates characterized by good oral activity and a coronary vascular selectivity greater than that of glyceryl trinitrate. Full structure-activity relationship studies of this new class of nitroesters are reported. From the screening of these compounds, ITF 296 was chosen for further evaluation.
Electroanatomic Ratios and Mortality in Patients With Heart Failure: Insights from the ASIAN‐HF Registry (2021)

Background QRS duration (QRSd) is a marker of electrical remodeling in heart failure. Anthropometrics and left ventricular size may influence QRSd and, in turn, may influence the association between QRSd and heart failure outcomes. Methods and Results Using the prospective, multicenter, multinational ASIAN-HF (Asian Sudden Cardiac Death in Heart Failure) registry, this study evaluated whether electroanatomic ratios (QRSd indexed for height or left ventricular end-diastole volume) are associated with 1-year mortality in individuals with heart failure with reduced ejection fraction. The study included 4899 individuals (aged 60±19 years, 78% male, mean left ventricular ejection fraction: 27.3±7.1%). In the overall cohort, QRSd was not associated with all-cause mortality (hazard ratio [HR], 1.003; 95% CI, 0.999-1.006, <i>P</i>=0.142) or sudden cardiac death (HR, 1.006; 95% CI, 1.000-1.013, <i>P</i>=0.059). QRS/height was associated with all-cause mortality (HR, 1.165; 95% CI, 1.046-1.296, <i>P</i>=0.005 with interaction by sex <i>p<sub>interaction</sub></i>=0.020) and sudden cardiac death (HR, 1.270; 95% CI, 1.021-1.580, <i>P</i>=0.032). QRS/left ventricular end-diastole volume was associated with all-cause mortality (HR, 1.22; 95% CI, 1.05-1.43, <i>P</i>=0.011) and sudden cardiac death (HR, 1.461; 95% CI, 1.090-1.957, <i>P</i>=0.011) in patients with nonischemic cardiomyopathy but not in patients with ischemic cardiomyopathy (all-cause mortality: HR, 0.94; 95% CI, 0.79-1.11, <i>P</i>=0.467; sudden cardiac death: HR, 0.734; 95% CI, 0.477-1.132, <i>P</i>=0.162). Conclusions Electroanatomic ratios of QRSd indexed for body size or left ventricular size are associated with mortality in individuals with heart failure with reduced ejection fraction. In particular, increased QRS/height may be a marker of high risk in individuals with heart failure with reduced ejection fraction, and QRS/left ventricular end-diastole volume may further risk stratify individuals with nonischemic heart failure with reduced ejection fraction. Registration URL: https://Clinicaltrials.gov. Unique identifier: NCT01633398.
Table and Suppl Figure legends from Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth (2023)

&lt;p&gt;legend of Table 1 &amp; Table 2 Legends of Supplementary Figures S1, S2, S3, S4 ,S5, S6&lt;/p&gt;
SELEX: How It Happened and Where It will Go (2015)

the ''NeXstar Moment,'' the ''SomaLogic Moment,'' and ''Next Moments.
Distinguishing Ventricular Arrhythmia Originating from the Right Coronary Cusp, Peripulmonic Valve Area, and the Right Ventricular Outflow Tract: Utility of Lead I (2013)

A relatively large R wave in lead I is seen with RCC origin but not PV origin. A sequential algorithm has limited but potentially significant value beyond assessment of lead I in approaching OTVA.
A label-free aptamer-based nanogap capacitive biosensor with greatly diminished electrode polarization effects (2018)

A significant impediment to the use of impedance spectroscopy in bio-sensing is the electrode polarization effect that arises from the movement of free ions to the electrode-solution interface, forming an electrical double layer (EDL). The EDL screens the dielectric response of the bulk and its large capacitance dominates the signal response at low frequency, masking information particularly relevant for biological samples, such as molecular conformation changes and DNA hybridization. The fabrication of nanogap capacitors with electrode separation less than the EDL thickness can significantly reduce electrode polarization effects and provide enormous improvement in sensitivity due to better matching of the sensing volume with the size of the target entities. We report on the fabrication of a horizontal thin-film nanogap capacitive sensor with electrode separation of 40 nm that shows almost no electrode polarization effects when measured with water and ionic buffer solutions, thereby allowing direct quantification of their relative permittivity at low frequencies. Surface modification of the electrodes with thiol-functionalized single strand DNA aptamers transforms the device into a label-free biosensor with high sensitivity and selectivity towards the detection of a specific protein. Using this approach, we have developed a biosensor for the detection of human alpha thrombin. In addition, we also examine frequency dependent permittivity measurements on high ionic strength solutions contained within the nanogap and discuss how these support recent experimental observations of large Debye lengths. A large shift in the Debye relaxation frequency to lower frequency is also found, which is consistent with water molecules being in a rigid-like state, possibly indicating the formation of an ordered "ice-like" phase. Altogether, this work highlights the need for better understanding of fluids in confined, nanoscale geometries, from which important new applications in sensing may arise.
Improving Network Performance through Policy-Based Management Applied to Generalized Multi-protocol Label Switching (2005)

Automatically switched circuit establishment is a big step for the operators towards the automation of transport services. The aim is to reduce OPEX while improving service capabilities through a distributed generalized multi-protocol label switching (GMPLS) control plane. Nevertheless, the control plane may not operate on its own and, hence, network operators need a holistic service production platform where intensified traffic engineering (TE) capabilities exist when operating the control plane. The aim of this paper is to point out and discuss issues to be addressed and to provide guiding principles as well as a policy-based management (PBM) solution pertaining to enhanced TE related to the GMPLS control plane protocols and the corresponding network management issues.
Effects of an Antihypertensive Combination in Japanese Hypertensive Outpatients Based on the Long-acting Calcium Channel Blocker Benidipine on Vascular and Renal Events: A Sub-analysis of the COPE Trial (2020)

Blood pressure-lowering therapy with benidipine combined with an ARB, β-blocker, or thiazide was similarly effective in the prevention of vascular and renal events in hypertensive outpatients, although there are not enough events to compare the difference in the three treatment groups.