gebhart/patrepeval huggingface dataset:
Successful production of offspring after superovulation and in vitro culture of embryos from domestic ferrets (Mustela putorius furos) (2001)

In an effort to expand the use of ferrets as models for genetic disease, several experimental parameters that are required for successful genetic manipulation in this species were investigated. Optimum superovulation (19.3 +/- 0.6 oocytes and embryos per female) was achieved after injections of 100 iu equine chorionic gonadotrophin (eCG) and 150 iu human chorionic gonadotrophin (hCG). The ovulation rate achieved by the treatment was more than double that induced by mating. Mating with a male immediately after hCG treatment did not significantly alter the number of oocytes ovulated or the number of embryos present, indicating that mating is not required for superovulation in ferrets. Of embryos harvested at the one-cell stage, 64.5% and 47.1% developed into blastocysts when cultured in vitro in CZB or TCM-199 plus 10% fetal bovine serum (FBS) media, respectively. In contrast, only 17.1% of embryos cultured in vitro in NCSU-23 developed to the blastocyst stage. Both freshly retrieved and in vitro cultured embryos from cinnamon-coloured parents produced live young when transferred at the eight-cell stage into albino, pseudo-pregnant recipients. The percentage of kits delivered relative to embryos transferred was 61% for freshly retrieved embryos and 32% for embryos cultured in vitro. These results demonstrate successful embryo transfer in ferrets and provide a basis for further study of genetic modelling approaches in this species after embryo manipulation.
The Top Prescription Drugs of 2011 in the United States: Antipsychotics and Antidepressants Once Again Lead CNS Therapeutics (2012)

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTADDITION / CORRECTIONThis article has been corrected. View the notice.The Top Prescription Drugs of 2011 in the United States: Antipsychotics and Antidepressants Once Again Lead CNS TherapeuticsCraig W. LindsleyCite this: ACS Chem. Neurosci. 2012, 3, 8, 630–631Publication Date (Web):August 15, 2012Publication History Published online15 August 2012Published inissue 15 August 2012https://pubs.acs.org/doi/10.1021/cn3000923https://doi.org/10.1021/cn3000923editorialACS PublicationsCopyright © 2012 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views13827Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (157 KB) Get e-AlertscloseSUBJECTS:Cancer,Diseases and disorders,Lipids,Pharmaceuticals,Therapeutics Get e-Alerts
A highly efficient and multifunctional biomass supporting Ag, Ni, and Cu nanoparticles through wetness impregnation for environmental remediation (2018)

Abstract Plant-based materials are reported to have a wide range of applications in the environmental and biomedical sectors. In this report, we present an economic and environmentally friendly supported turmeric powder (TP) biomass for the support of Ag, Ni and Cu nanoparticles (NPs) designated as Ag@TP, Ni@TP and Cu@TP. The in situ syntheses of the stated NPs were achieved in aqueous medium using NaBH 4 as a reducing agent. The prepared NPs were applied for the degradation of o -nitrophenol (ONP), m -nitrophenol (MNP), p -nitrophenol (PNP), methyl orange (MO), Congo red (CR), rhodamine B (RB) and methylene blue (MB). Initially, Ag@TP, Ni@TP and Cu@TP were screened for the MO dye and antibacterial activity, where Ag@TP displayed the strongest catalytic activity for MO and bactericidal activities as compared to Ni@TP and Cu@TP. The quantity of metal ions adsorbed onto the TP was investigated by atomic absorption spectroscopy. The Ag@TP, Ni@TP and Cu@TP were characterized through X-ray diffraction (XRD), attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, thermal gravimetric analysis (TGA), energy-dispersive X-ray spectroscopy (EDS) and field emission scanning electron microscope (FESEM) analysis.
1.48 mu m high-power GaInAsP-InP graded-index separate-confinement-heterostructure multiple-quantum-well laser diodes (1993)

High-power 1.48- mu m graded-index separate-confinement-heterostructure multiple-quantum-well laser diodes (GRIN-SCH MQW LDs) have been investigated in terms of the beam divergence, threshold current, and differential quantum efficiency. A calculation predicts that narrow beam divergence perpendicular to the junction plane could be obtained by the use of small number of step quaternary layers with wide bandgap. Experimentally, the threshold current increased due to the small optical confinement, although the beam divergence became small. The full width at half maximum (FWHM) of the far-field pattern in the horizontal direction was 20 degrees and that in the vertical direction was 25 degrees . Output power as high as 208 mW was achieved at a driving current of 1000 mA for a 1-mm-long device. Stable transverse mode operation was confirmed up to the maximum output power. Coupling efficiency of 89% and output power from a single-mode fiber of 185 mW were obtained at 25 degrees C.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Abstract 224: Antibody-drug conjugates (ADCs) of a new class of N-10 amino linked DNA alkylating indolino-benzodiazepines (IGNs) (2019)

We have previously reported on our antibody-drug conjugates (ADCs) that incorporate a highly potent novel DNA alkylating indolino-benzodiazepine (termed IGN) dimer. ADCs of these DNA alkylating IGNs were found preclinically to demonstrate better tolerability and an improved overall therapeutic index (TI) compared with those of the corresponding DNA crosslinking IGNs (Miller, et al., Mol. Cancer Ther. 2016, 2018). IGN-containing ADCs that have reached the clinical stage bear DNA alkylating IGN compounds linked to the antibody via a cleavable linker, incorporated at the amino group of a centrally located anilino spacer moiety. In our ongoing effort to further explore the structure-activity relationship (SAR) of DNA alkylating effector molecules for ADCs, we disclose here a new class of IGNs possessing a self-immolative peptide linker attached at the N-10 amine of the imine-reduced IGN monomer subunit. We explored the impact of modifying the central spacer group connecting the IGN monomers, and site of linkage on in vitro potency and the interaction with DNA. A set of IGN molecules that met our potency criteria were identified and linkable forms of these compounds were prepared and conjugated to a folate receptor-α (FRα)-binding antibody. These ADCs displayed potent, antigen-specific in vitro activity across a panel of FRα-expressing cell lines. A lead ADC selected for in vivo studies demonstrated high stability in plasma and potent efficacy in various xenograft models, at doses well below the maximum tolerated dose. Thus, IGNs modified with an N-10 self-immolative peptide linker are promising DNA alkylating effector molecules for use in ADCs.Citation Format: Michael L. Miller, Emily E. Reid, Katie E. Archer, Luke Harris, Erin K. Maloney, Laura M. Bartle, Olga Ab, Alan J. Wilhelm, Jose F. Ponte, Rajeeva Singh, Thomas A. Keating, Ravi V. Chari. Antibody-drug conjugates (ADCs) of a new class of N-10 amino linked DNA alkylating indolino-benzodiazepines (IGNs) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 224.
Rules for Antiparallel β-Sheet Design:  d-Pro-Gly Is Superior to l-Asn-Gly for β-Hairpin Nucleation1 (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTRules for Antiparallel β-Sheet Design: d-Pro-Gly Is Superior to l-Asn-Gly for β-Hairpin Nucleation1Heather E. Stanger and Samuel H. GellmanView Author Information Department of Chemistry, University of Wisconsin Madison, Wisconsin 53706 Cite this: J. Am. Chem. Soc. 1998, 120, 17, 4236–4237Publication Date (Web):April 22, 1998Publication History Received27 October 1997Published online22 April 1998Published inissue 1 May 1998https://pubs.acs.org/doi/10.1021/ja973704qhttps://doi.org/10.1021/ja973704qrapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1685Altmetric-Citations236LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Conformation,Peptides and proteins,Protein folding,Sodium,Solution chemistry Get e-Alerts
Final report and documentation for the security enabled programmable switch for protection of distributed internetworked computers LDRD. (2010)

An increasing number of corporate security policies make it desirable to push security closer to the desktop. It is not practical or feasible to place security and monitoring software on all computing devices (e.g. printers, personal digital assistants, copy machines, legacy hardware). We have begun to prototype a hardware and software architecture that will enforce security policies by pushing security functions closer to the end user, whether in the office or home, without interfering with users' desktop environments. We are developing a specialized programmable Ethernet network switch to achieve this. Embodied in this device is the ability to detect and mitigate network attacks that would otherwise disable or compromise the end user's computing nodes. We call this device a 'Secure Programmable Switch' (SPS). The SPS is designed with the ability to be securely reprogrammed in real time to counter rapidly evolving threats such as fast moving worms, etc. This ability to remotely update the functionality of the SPS protection device is cryptographically protected from subversion. With this concept, the user cannot turn off or fail to update virus scanning and personal firewall filtering in the SPS device as he/she could if implemented on the end host. The SPS concept also provides protection to simple/dumb devices such as printers, scanners, legacy hardware, etc. This report also describes the development of a cryptographically protected processor and its internal architecture in which the SPS device is implemented. This processor executes code correctly even if an adversary holds the processor. The processor guarantees both the integrity and the confidentiality of the code: the adversary cannot determine the sequence of instructions, nor can the adversary change the instruction sequence in a goal-oriented way.
Separation of semiconducting and ferromagnetic FeSi2-nanoparticles by magnetic filtering (2013)

We have investigated the potential of solution-processed β-phase iron disilicide (FeSi2) nanoparticles as a novel semiconducting material for photovoltaic applications. Combined ultraviolet-visible absorption and photothermal deflection spectroscopy measurements have revealed a direct band gap of 0.85 eV and, therefore, a particularly high absorption in the near infrared. With the help of Fourier-transform infrared and X-ray photoelectron spectroscopy, we have observed that exposure to air primarily leads to the formation of a silicon oxide rather than iron oxide. Mössbauer measurements have confirmed that the nanoparticles possess a phase purity of more than 99%. To diminish the small fraction of metallic iron impurities, which were detected by superconducting quantum interference device magnetometry and which would act as unwanted Auger recombination centers, we present a novel concept to magnetically separate the FeSi2 nanoparticles (NPs). This process leads to a reduction of more than 95% of the iron impurities.
Leadless IC package with a substrate produced by copper/nickel/copper-3-layer-clad material (2011)

Terminal units such as mobile phones, portable game systems and electronic books, have spread all over the world and advanced to be smaller, more lightweight and thinner every moment. Simultaneously, the inner electronic parts such as batteries, IC packages and connectors were also smaller and thinner. For example, in order to reduce the occupied area and space on the printed circuit board (PCB), some lead flame type IC packages such as SOP(Small Outline Package) and QFP(Quad Flat Package) have changed to leadless type ones such as SON(Small Outline Non-lead), QFN(Quad Flat Non-lead) and LGA. (Land Grid Array) The substrates of such leadless IC packages are usually made of a single metal plate such as a copper, a copper alloy and a nickel and conventionally produced through etching process or plating process. So the designs for the package like the size, the number of terminal and the total thickness are limited. In order to solve such problems, we developed a new manufacturing method, using clad materials which rolled copper (Cu) foil and nickel (Ni) plating layer on electrolysis Cu foil were laminated. In detail, the components were consisting of 18μm to 35μm thickness Cu foil with about 1 um thickness Ni plating layer and around 100μm thickness rolled Cu sheet (Cu/Ni/Cu material). These materials are characterized by the cladding interface between the rolled Cu foil and the Ni plating layer on the electrolysis Cu foil, which is bonded by the surface activated bonding (SAB) method [1, 2, 3]. Namely, the interface is so flat that it is suitable to use for selective etching work [4, 5]. In this paper, we would like to introduce the new IC package manufacturing process with the Cu/Ni/Cu material. This method makes some new package designs possible and achieves high productivity when comparing to the conventional method. We produced various leadless IC packages with the total thickness of 0.25mm to 0.5mm, with the number of 3 to 460 terminals at 1 row to 4 rows for terminals by means of this new method. In addition, in order to evaluate the package performance, we made the package with the total thickness of 0.43mm, with 164 terminals of diameter of 0.25mm at 3 rows and the terminal pitch of 0.5mm. In this sample, heat-tolerance by the solder reflow test with the pre-condition of JEDEC (Joint Electron Device Engineering Council) standard of level 3 was estimated and the package warpage in the range of 25 to 260 degrees Celsius was measured. As the results, the package sample could pass the reflow test of the JEDEC level 3 and the warp of the package was less than 50μm.
Proceedings of the 1st international workshop on Search and mining entity-relationship data (2011)

It is our great pleasure to welcome you to the 1st International Workshop on Search and Mining Entity-Relationship Data -- SMER 2011, held at CIKM 2011 in Glasgow on October 28, 2011.

Data complexity and its diversity have been rapidly expanding over the last years. Numerous applications in various domains such as social-media, healthcare, e-commerce, and business intelligence require new methods and tools for collecting and extracting entities and their relationships from unstructured data sources to be transformed into useful knowledge. Even though lots of useful facts are being added on a daily basis on multitude web and enterprise data sources, they are still hidden behind barriers of language constraints, data heterogeneity and ambiguity, and the lack of proper query interfaces. In addition, novel search and data mining methods are required to provide expressive and powerful discovery capabilities, yet intuitive enough, for exploring the large amounts of entity-relationship data.

The workshop picks up these problems in two main themes. The first is search and discovery over rich entity-relationship data and includes among others topics such as ER data collection, indexing, query languages and optimization, ranking methods, similarity and exploratory search, privacy, etc. The second theme is entity-relationship data mining methods and includes among others topics such ER data extraction, resolution, representation, fusion, ER graph mining, etc. The workshop main objective is to serve as an open forum for discussing the new research challenges in search and mining of large scale ER data extracted from multitude of unstructured and semi-structured data sources, driven by recent industry trends and requirements in various domains and increasing academic interest. The workshop will bring together researchers from different communities working on similar problems in the context of ER and other semantic data, allowing for cross-fertilization between areas. During the workshop, we will identify common problems and their various solution approaches in DB, KM, and IR.

The workshop will consist of three parts: 
Keynote talks by Michael Witbrock (Cycorp), Krisztian Balog (Norwegian University of Science and Technology), and David Carmel (IBM Research) with valuable insights from both research and industry,
three research talks and three posters, selected by the program committee from a total of 10 papers, with topics spanning from entity extraction methods to entity search and privacy, and
an open panel for discussing open issues and advances in ER search and data mining, serving as an open stage for interdisciplinary collaboration for facing the emerging research challenges.
P‐149: Influence of Interlayer Materials on Solution Processed OLEDs Based on Small Molecules (2014)

Abstract The influence of interlayer with fluorene and arylamine materials on solution processed organic light emitting devices using small molecules as emissive layer (SM‐OLEDs) was studied. The SM‐OLEDs using fluorene and arylamine‐containing polymer as interlayer had low efficiency and extremely short lifetime. On the other hand, the lifetime was improved by inserting arylamine‐containing hole transport material between interlayer and emissive layer. In our experiment using several materials of small molecules, we found that the presence of fluorene unit leads to significant decrease in lifetime.
The dynamics of gallamine: A potent neuromuscular blocker. A determination by quantum mechanics and molecular dynamics (i) in vacuo studies (1989)

Abstract The potent neuromuscular blocker, gallamine, possesses three chemically equivalent, flexible side chains, the motion of which has been proposed as important in its mode of action on the acetylcholine receptor in vivo. The flexibility of the side chains has been investigated in the present initial study by a combination of quantum mechanics and molecular dynamics on the isolated, unsolvated molecule. Net atomic charges for the gallamine molecule have been calculated using the semiempirical program MOPAC for use in the molecular dynamics simulation. The flexibility of the side chains has been shown to correlate with the range of fluctuations in torsion angles observed in the crystal structure of gallamine.
Feasibility of Immunohistochemistry on Endoscopic Ultrasound Fine-Needle Aspiration Samples for Evaluating Predictive Biomarkers in Pancreatic Cancer Management (2016)

SCOPUS: le.j
Advanced 1.3 &#x00B5;m vertical cavity lasers based on AlInGaAs/InP-AlGaAs/GaAs fused structures (2015)

We report on recent status of vertical cavity lasers emitting in the 1.3 μm waveband comprising AlInGaAs/InP active regions wafer fused to Al(Ga)As/GaAs distributed Bragg reflectors. This technique produces vertical cavity surface emitting lasers (VCSELs) emitting in 4 channels of the 1310 nm coarse wavelength division multiplexing band that enabled a new generation of transceivers operating at 40 Gbps over 2 km of standard single mode fiber with a power consumption as low as 1 W and vertical external cavity surface emitting lasers (VECSELs) with record output power of 8.5 W.
The Dissenters Volume III (2015)

Abstract This third and final volume of the study of dissent examines the turbulent times of Victorian Nonconformity, a period of faith and of doubt. The book assesses the impacts of the major Dissenting preachers and provides insights into the various movements, such as romanticism and the higher, often German, biblical criticism. It shows that the preaching of hell and eternal damnation was more effective in recruiting to the chapels than the gentler interpretations. The book analyses surviving records of attendance at Nonconformist services. It provides fascinating accounts of Spurgeon and the other key figures of Nonconformity, including of the Salvation Army. The book also discusses the contribution which Nonconformity made to the politics of mid- to late-Victorian Britain. It examines such issues of reform as Forster's Education Act of 1871, temperance, and Balfour's Education Act of 1902, and considers Nonconformist interventions in such controversies as the Bulgarian Agitation, Home Rule for Ireland, the Armenian massacres of the mid 1890s, and the Boer War. The volume concludes with the Liberal landslide in the 1906 general election, which saw probably more Nonconformists elected than any time since the era of Oliver Cromwell.
A Generalised Method for Empirical Game Theoretic Analysis (2018)

This paper provides theoretical bounds for empirical game theoretical analysis of complex multi-agent interactions. We provide insights in the empirical meta game showing that a Nash equilibrium of the meta-game is an approximate Nash equilibrium of the true underlying game. We investigate and show how many data samples are required to obtain a close enough approximation of the underlying game. Additionally, we extend the meta-game analysis methodology to asymmetric games. The state-of-the-art has only considered empirical games in which agents have access to the same strategy sets and the payoff structure is symmetric, implying that agents are interchangeable. Finally, we carry out an empirical illustration of the generalised method in several domains, illustrating the theory and evolutionary dynamics of several versions of the AlphaGo algorithm (symmetric), the dynamics of the Colonel Blotto game played by human players on Facebook (symmetric), and an example of a meta-game in Leduc Poker (asymmetric), generated by the PSRO multi-agent learning algorithm.