gebhart/patrepeval huggingface dataset:
A novel combination of cyclophosphamide and anti-ICOS mAb prevents tumor growth by affecting regulatory T cells in mice with a human immune system (2018)

Mice reconstituted with a human immune system and bearing human tumors represent a promising model for developing novel cancer immunotherapy strategies. However, the nature of tumor infiltrating leukocytes in humanized mice and whether they can be mobilized to control tumor growth is currently unknown. Here, we used mass cytometry and multi parametric flow cytometry to characterize human leukocytes infiltrating a human breast cancer tumor model in CD34-reconstituted NOD.SCID.gc-null mice and compared it to breast cancer patient samples. We unambiguously detected human T cells, monocytes and plasmacytoid dendritic cells in the tumors of humanized mice. Importantly, activated/memory T cells and ICOS+ regulatory T cells were enriched in the tumor relative to the periphery both in humanized mice and in breast cancer patients. The presence of ICOS+ regulatory T cells in the tumor has been associated with poor survival in breast cancer patients. Administration of a neutralizing mAb to human ICOS reduced regulatory T cells, and a combination of the anti-ICOS mAb and chemotherapy reduced tumor growth whereas single treatments had no or little effects. Besides characterizing human leukocytes in tumors of humanized mice, we show that a combination of anti-ICOS and chemotherapy can mobilize human leukocytes to control tumor growth in vivo, making it a promising strategy in humans.
Effects of Cyclic Pressure on Bone Marrow Cell Cultures (2002)

The present in-vitro study used bone marrow cell cultures and investigated the effects of cyclic pressure on osteoclastic bone resorption. Compared to control (cells maintained under static conditions), the number of tartrate resistant acid phosphatase (TRAP)-positive, osteoclastic cells was significantly (p<0.05) lower when, immediately upon harvesting, bone marrow cells were exposed to cyclic pressure (10-40 kPa at 1.0 Hz). In contrast, once precursors in bone marrow cells differentiated into osteoclastic cells under static culture conditions for 7 days, subsequent exposure to the cyclic pressure of interest to the present study did not affect the number of osteoclastic cells. Most important, exposure of bone marrow cells to cyclic pressure for 1 h daily for 7 consecutive days resulted in significantly (p<0.05) lower osteoclastic bone resorption and in lowered mRNA expression for interleukin-1 (IL-1) and tumor necrosisfactor-a (TNF-a), cytokines that are known activators of osteoclast function. In addition to unique contributions to osteoclast physiology, the present study provided new evidence of a correlation between mechanical loading and bone homeostasis as well as insight into the molecular mechanisms of bone adaptation to mechanical loading, namely cytokine-mediated control of osteoclast functions.
Stuff I've seen (2003)

Most information retrieval technologies are designed to facilitate information discovery. However, much knowledge work involves finding and re-using previously seen information. We describe the design and evaluation of a system, called Stuff I've Seen (SIS), that facilitates information re-use. This is accomplished in two ways. First, the system provides a unified index of information that a person has seen, whether it was seen as email, web page, document, appointment, etc. Second, because the information has been seen before, rich contextual cues can be used in the search interface. The system has been used internally by more than 230 employees. We report on both qualitative and quantitative aspects of system use. Initial findings show that time and people are important retrieval cues. Users find information more easily using SIS, and use other search tools less frequently after installation.
Adenoid cystic carcinoma: emerging role of translocations and gene fusions (2016)

Adenoid cystic carcinoma (ACC), the second most common salivary gland malignancy, is notorious for poor prognosis, which reflects the propensity of ACC to progress to clinically advanced metastatic disease. Due to high long-term mortality and lack of effective systemic treatment, the slow-growing but aggressive ACC poses a particular challenge in head and neck oncology. Despite the advancements in cancer genomics, up until recently relatively few genetic alterations critical to the ACC development have been recognized. Although the specific chromosomal translocations resulting in MYB-NFIB fusions provide insight into the ACC pathogenesis and represent attractive diagnostic and therapeutic targets, their clinical significance is unclear, and a substantial subset of ACCs do not harbor the MYB-NFIB translocation. Strategies based on detection of newly described genetic events (such as MYB activating super-enhancer translocations and alterations affecting another member of MYB transcription factor family-MYBL1) offer new hope for improved risk assessment, therapeutic intervention and tumor surveillance. However, the impact of these approaches is still limited by an incomplete understanding of the ACC biology, and the manner by which these alterations initiate and drive ACC remains to be delineated. This manuscript summarizes the current status of gene fusions and other driver genetic alterations in ACC pathogenesis and discusses new therapeutic strategies stemming from the current research.
Computational Performance of Time-Resolved Diffuse Optical Tomography in a Two-Layer Brain Model (2018)

We evaluate Mellin-Laplace algorithm in a two-layer brain model with Monte-Carlo generated data. Results show accurate absorption estimation and the flexibility of the algorithm to detect each layer thickness.
Synthesis and application in asymmetric C–C bond formation of solution phase ligand libraries of monodentate phosphoramidites (2004)

A library of 96 unique monodentate phosphoramidite ligands has been synthesized in solution and used in the asymmetric conjugate addition of potassium vinyltrifluoroborate to enones resulting in up to 88% ee.
Flow and Dispersion Characteristics of a Stack-Issued Backward Inclined Jet in Crossflow (2016)

Abstract The effects of backward inclination angle on flow characteristics and jet dispersion properties of a stack-issued jet in crossflow were studied by means of instantaneous and long-exposure photography, particle image velocimetry (PIV), and tracer-gas concentration detections at a Reynolds number of 2,400, a jet-to-crossflow momentum flux ratio of 1.0, and the backward inclination angles θ = 0° - 60°. Three characteristic flow patterns featured by different near-wake flow structures were found within the surveyed span of the backward inclination angle: low ( θ ≤ 25°), mediate (25° &lt; θ &lt; 50°), and high ( θ ≥ 50°). In the range of low backward inclination angle, mushroom vortices appeared in the upwind shear layer. Jet fluids were entrained into the jet- and tube-wakes because the near wake region was characterized by a jet-wake vortex and a downwash flow. In the range of mediate backward inclination angle, forward-rolling vortices were formed in the upwind shear layer. Jet fluids were entrained into the jet wake but not appearing in the tube wake because the near wake was characterized by an isolated tube wake and up-going flows. In the range of high backward inclination angle , small-sized forward-rolling vortices were observed in the upwind shear layer. Jet fluids were not observed in both the jet- and tube-wakes because all flows went forward without reversal or vortex, which was similar to that in a jet in co-flow. Large turbulence intensities occurred around the jet-wake vortex and along sides of the tube wake bifurcation line, therefore the mixing at the low backward inclination angles presented better properties than those at mediate and high backward inclination angles owing to the featured flow structures and turbulence intensities.
Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer (2015)

Despite advances in precision medicine approaches over the past decade, the majority of nonsmall cell lung cancers (NSCLCs) are refractory to treatment with targeted small molecule inhibitors. Previous work has identified mutations in the Discoidin Domain Receptor 2 (DDR2) kinase as potential therapeutic targets in NSCLCs. While DDR2 is potently targeted by several multitargeted kinase inhibitors, most notably dasatinib, toxicity has limited the clinical application of anti-DDR2 therapy. Here, we have characterized compound 1 and other tool compounds demonstrating selectivity for DDR2 and show that while these compounds inhibit DDR2 in lung cancer model systems, they display limited antiproliferative activity in DDR2 mutated cell lines as compared to dual DDR2/SRC inhibitors. We show that DDR2 and SRC are binding partners, that SRC activity is tied to DDR2 activation, and that dual inhibition of both DDR2 and SRC leads to enhanced suppression of DDR2 mutated lung cancer cell lines. These results support the further evaluation of dual SRC/DDR2 targeting in NSCLC, and we report a tool compound, compound 5, which potently inhibits both SRC and DDR2 with a distinct selectivity profile as compared to dasatinib.
[Bmim]BF4‐Immobilized Rhenium‐Catalyzed Highly Efficient Oxygenation of Aldimines to Oxaziridines Using Solid Peroxides as Oxidants. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Method and apparatus for producing a carbon based foam article having a desired thermal-conductivity gradient (2023)

A carbon based foam article is made by heating the surface of a carbon foam block to a temperature above its graphitizing temperature, which is the temperature sufficient to graphitize the carbon foam. In one embodiment, the surface is heated with infrared pulses until heat is transferred from the surface into the core of the foam article such that the graphitizing temperature penetrates into the core to a desired depth below the surface. The graphitizing temperature is maintained for a time sufficient to substantially entirely graphitize the portion of the foam article from the surface to the desired depth below the surface. Thus, the foam article is an integral monolithic material that has a desired conductivity gradient with a relatively high thermal conductivity in the portion of the core that was graphitized and a relatively low thermal conductivity in the remaining portion of the foam article.
Solution-Processable Quinoidal Dithioalkylterthiophene-Based Small Molecules Pseudo-Pentathienoacenes via an Intramolecular S···S Lock for High-Performance n-Type Organic Field-Effect Transistors (2020)

A new organic small-molecule family comprising tetracyanoquinodimethane-substituted quinoidal dithioalky(SR)terthiophenes (<b>DSTQ</b>s) (<b>DSTQ-6</b> (<b>1</b>); SR = SC<sub>6</sub>H<sub>13</sub>, <b>DSTQ-10</b> (<b>2</b>); SR = SC<sub>10</sub>H<sub>21</sub>, <b>DSTQ-14</b> (<b>3</b>); SR = SC<sub>10</sub>H<sub>21</sub>) was synthesized and contrasted with a nonthioalkylated analogue (<b>DRTQ-14</b> (<b>4</b>); R = C<sub>14</sub>H<sub>29</sub>). The physical, electrochemical, and electrical properties of these new compounds are thoroughly investigated. Optimized geometries obtained from density functional theory calculations and single-crystal X-ray diffraction reveal the planarity of the SR-containing <b>DSTQ</b> core. <b>DSTQ</b>s pack in a slipped π-π stacked two-dimensional arrangement, with a short intermolecular stacking distance of 3.55 Å and short intermolecular S···N contacts of 3.56 Å. Thin-film morphological analysis by grazing incident X-ray diffraction reveals that all <b>DSTQ</b> molecules are packed in an edge-on fashion on the substrate. The favorable molecular packing, the high core planarity, and very low lowest unoccupied molecular orbital (LUMO) energy level (-4.2 eV) suggest that <b>DSTQ</b>s could be electron-transporting semiconductors. Organic field-effect transistors based on solution-sheared <b>DSTQ-14</b> exhibit the highest electron mobility of 0.77 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> with good ambient stability, which is the highest value reported to date for such a solution process terthiophene-based small molecular semiconductor. These results demonstrate that the device performance of solution-sheared <b>DSTQ</b>s can be improved by side chain engineering.
Coarse-grained speculative execution in shared-memory multiprocessors (1998)

Article Free Access Share on Coarse-grained speculative execution in shared-memory multiprocessors Authors: Iffat H. Kazi Department of Electrical and Computer Engineering, University of Minnesota, 200 Union St. SE, Minneapolis, MN Department of Electrical and Computer Engineering, University of Minnesota, 200 Union St. SE, Minneapolis, MNView Profile , David J. Lilja Department of Electrical and Computer Engineering, University of Minnesota, 200 Union St. SE, Minneapolis, MN Department of Electrical and Computer Engineering, University of Minnesota, 200 Union St. SE, Minneapolis, MNView Profile Authors Info & Claims ICS '98: Proceedings of the 12th international conference on SupercomputingJuly 1998 Pages 93–100https://doi.org/10.1145/277830.277853Published:13 July 1998Publication History 8citation263DownloadsMetricsTotal Citations8Total Downloads263Last 12 Months12Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
The sialyltransferase ST3Gal-IV guides murine T-cell progenitors to the thymus (2020)

T lymphocytes are important players in beneficial and detrimental immune responses. In contrast to other lymphocyte populations that develop in the bone marrow, T-cell precursors need to migrate to the thymus for further development. The interaction of P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) is crucial for thymic entry of T-cell precursors during settings of T-cell lineage reconstitution. PSGL-1 has to be sialylated to function as a ligand for P-selectin, and the sialyltransferase ST3Gal-IV might play a critical role in this process. We therefore investigated the role of ST3Gal-IV for T-cell development using competitive mixed bone marrow chimeric mice. We found that ST3Gal-IV is dispensable for homing and engraftment of hematopoietic precursors in the bone marrow. However, ST3Gal-IV deficiency affects seeding of the thymus by early T-cell progenitors, leading to impaired restoration of the peripheral T-cell compartment. This defect could be restored by ectopic retroviral expression of ST3Gal-IV in hematopoietic stem cells derived from ST3Gal-IV-deficient donor mice. Our findings show that ST3Gal-IV plays a critical and nonredundant role for efficient T-cell lineage reconstitution after bone marrow transplantation.
Priming Dental Pulp Stem Cells With Fibroblast Growth Factor-2 Increases Angiogenesis of Implanted Tissue-Engineered Constructs Through Hepatocyte Growth Factor and Vascular Endothelial Growth Factor Secretion (2016)

Tissue engineering strategies based on implanting cellularized biomaterials are promising therapeutic approaches for the reconstruction of large tissue defects. A major hurdle for the reliable establishment of such therapeutic approaches is the lack of rapid blood perfusion of the tissue construct to provide oxygen and nutrients. Numerous sources of mesenchymal stem cells (MSCs) displaying angiogenic potential have been characterized in the past years, including the adult dental pulp. Establishment of efficient strategies for improving angiogenesis in tissue constructs is nevertheless still an important challenge. Hypoxia was proposed as a priming treatment owing to its capacity to enhance the angiogenic potential of stem cells through vascular endothelial growth factor (VEGF) release. The present study aimed to characterize additional key factors regulating the angiogenic capacity of such MSCs, namely, dental pulp stem cells derived from deciduous teeth (SHED). We identified fibroblast growth factor-2 (FGF-2) as a potent inducer of the release of VEGF and hepatocyte growth factor (HGF) by SHED. We found that FGF-2 limited hypoxia-induced downregulation of HGF release. Using three-dimensional culture models of angiogenesis, we demonstrated that VEGF and HGF were both responsible for the high angiogenic potential of SHED through direct targeting of endothelial cells. In addition, FGF-2 treatment increased the fraction of Stro-1+/CD146+ progenitor cells. We then applied in vitro FGF-2 priming to SHED before encapsulation in hydrogels and in vivo subcutaneous implantation. Our results showed that FGF-2 priming is more efficient than hypoxia at increasing SHED-induced vascularization compared with nonprimed controls. Altogether, these data demonstrate that FGF-2 priming enhances the angiogenic potential of SHED through the secretion of both HGF and VEGF.
ChemInform Abstract: Chemoselective Transfer Hydrogenation Reactions over Calcined‐Layered Double Hydroxides. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Atomic-Resolution Imaging and Spectroscopy of Functionalized MXene Nanosheets (2020)

MXenes are a large and fast-growing family of two-dimensional materials. Their name highlights their sheet-like nature (as is often associated with graphene) and their synthesis from a parent MAX phase material. MXenes -Mn+1XnTx , where M is a transition metal, X is carbon or nitrogen and T is the surface functional group -are typically synthesized from a MAX phase bulk material though etching the main group element (A) with aqueous HF solutions or more recently with Lewis acidic molten salts 1. With over 80 experimentally synthesized MAX phases, the MXene family has potential to become the most diverse family among 2D materials. Since first synthesized in 2011 2 , MXenes have been an active field of research due to their exciting properties; for example, reports have shown MXenes to have higher conductivity than graphene, tunable band structure, and high charge capacitance. This has made MXenes a promising candidate material for applications in energy storage, fuel cells, electronic interference shielding, supercapacitors and many more 3 .
Frequency noise measurements of lasers locked to a rubidium mastered optical cavity (2002)

A small, evacuated, piezoelectrically-tuned Fabry-Perot cavity is stabilized using a commercial rubidium oscillator. The cavity's resonance is measured and controlled using two diode-pumped Nd:YAG lasers; each locked to a mode of the cavity. Once controlled the cavity resonance acts as a frequency reference for the lasers. To measure the laser frequency noise, one of the laser beams is combined with a laser beam from an identical system. The beat frequency between the two lasers allows a measure of the linewidth, frequency noise and root Allan variance of a single laser. This data is reported and compared to results from more elaborate laser frequency control schemes.
Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity (2021)

An interruption in Aβ homeostasis leads to the deposit of neurotoxic amyloid plaques and is associated with Alzheimer's disease. A supramolecular strategy based on the assembly of peptidomimetic agents into functional vesicles has been conceived for the simultaneous inhibition of Aβ<sub>42</sub> fibrillation and expedited clearance of Aβ<sub>42</sub> aggregates. Tris-pyrrolamide peptidomimetic, ADH-353, contains one hydrophobic <i>N</i>-butyl and two hydrophilic <i>N</i>-propylamine side chains and readily forms vesicles under physiological conditions. These vesicles completely rescue both mouse neuroblastoma N2a and human neuroblastoma SH-SY5Y cells from the cytotoxicity that follows from Aβ<sub>42</sub> misfolding likely in mitochondria. Biophysical studies, including confocal imaging, demonstrate the biocompatibility and selectivity of the approach toward this aberrant protein assembly in cellular milieu.
Mid-IR laser system for advanced neurosurgery (2014)

We present work on a laser system operating in the near- and mid-IR spectral regions, having output characteristics designed to be optimal for cutting various tissue types. We provide a brief overview of laser-tissue interactions and the importance of controlling certain properties of the light beam. We describe the principle of operation of the laser system, which is generally based on a wavelength-tunable alexandrite laser oscillator/amplifier, and multiple Raman conversion stages. This configuration provides robust access to the mid-IR spectral region at wavelengths, pulse energies, pulse durations, and repetition rates that are attractive for neurosurgical applications. We summarize results for ultra-precise selective cutting of nerve sheaths and retinas with little collateral damage; this has applications in procedures such as optic-nerve-sheath fenestration and possible spinal repair. We also report results for cutting cornea, and dermal tissues.
Prolonged Duration Topical Corneal Anesthesia With the Cationic Lidocaine Derivative QX-314 (2019)

Our study reveals a clinically relevant compound providing prolonged duration topical corneal anesthesia.
The effect of wall adhesion on the determination of the compressive strength of strongly cohesive particulate gels by the centrifuge method (2014)

Several methods for measuring the compressive strength of strong particulate gels are available, including the centrifuge method, whereby the strength as a function of volume-fraction is obtained parametrically from the dependence of equilibrium sediment height upon acceleration. The analysis used conventionally due to Buscall & White (1987) ignores the possibility that the particulate network might adhere to the walls of the centrifuge tube, even though many types of cohesive particulate gel can be expected to adhere to bounding surfaces. The neglect of adhesion is justifiable when the ratio of the shear to compressive strength is small, which it can be for many systems well above the gel-point, but never very very near it. The errors arising from neglect of adhesion are investigated theoretically and quantified by synthesising model equilibrium sediment height versus acceleration data for various degrees of adhesion and then analysing them in the conventional manner. Approximate correction factors suggested by dimensionless analysis are then tested. The errors introduced by certain other approximations made routinely in order to render the data-inversion facile tractable are analysed too.