gebhart/patrepeval huggingface dataset:
Internal electrical phase inversion for FF-beam resonator arrays and tuning fork filters (2008)

This paper reports on a novel MEMS electrical phase inverter resonator filter driving using differential DC bias. The internal electrical phase inverter mechanism is demonstrated by a clamped-clamped (CC) beam resonator and wire coupled free-free (FF) beam resonator arrays with in-phase or differential DC-bias. The filter performance is then demonstrated by an anchor coupled double-ended tuning fork (DETF) resonator and is realized in a silicon microfabrication process. The filter bandwidth is voltage tunable employing the electrical spring softening effect and the minimum tunable bandwidth is set by the energy coupling between neighbouring modes.
Physical mapping of 32 genetic markers on the Pseudomonas aeruginosa PAO1 chromosome (1996)

The Pseudomonas aeruginosa chromosome was fractionated with the enzymes SpeI and DpnI, and genomic fragments were separated by PFGE and used for mapping a collection of 40 genes. This permitted the localization of 8 genes previously mapped and of 32 genes which had not been mapped. We showed that a careful search of databases and identification of sequences that were homologous to known genes could be used to design and synthesize DNA probes for the mapping of P. aeruginosa homologues by Southern hybridization with genomic fragments, resulting in definition of the locations of the aro-2, dapB, envA, mexA, groEL, oprH, oprM, oprP, ponA, rpoB and rpoH genetic markers. In addition, a combination of distinct DNA sources were utilized as radioactively labelled probes, including specific restriction fragments of the cloned genes (glpD, opdE, oprH, oprO, oprP, phoS), DNA fragments prepared by PCR, and single-stranded DNA prepared from phagemid libraries that had been randomly sequenced. We used a PCR approach to clone fragments of the putative yhhF, sucC, sucD, cypH, pbpB, murE, pbpC, soxR, ftsA, ftsZ and envA genes. Random sequencing of P. aeruginosa DNA from phagemid libraries and database searching permitted the cloning of sequences from the acoA, catR, hemD, pheS, proS, oprD, pyo and rpsB gene homologues. The described genomic methods permit the rapid mapping of the P. aeruginosa genome without linkage analysis.
Supplementary Data from Polysaccharide Krestin Is a Novel TLR2 Agonist that Mediates Inhibition of Tumor Growth via Stimulation of CD8 T Cells and NK Cells (2023)

&lt;p&gt;Supplementary Figures S1-S2.&lt;/p&gt;
Variable angle spectroscopic magneto-optics and ellipsometry: Application to DyCo multilayers (abstract) (1988)

The purpose of this paper is twofold. First, we describe the adaptation of a variable angle spectroscopic ellipsometer (VASE) to magneto-optic measurements covering 3000–8000 Å, and 0 to ±8 kOe. Second, we describe application of VASE to determine Kerr rotation and ellipticity for a series of Dy/Co multilayers prepared by sputter deposition. We report spectroscopic ellipsometric and Kerr effect results for samples exhibiting perpendicular magnetic anisotropy, since these are relevant as magneto-optic recording media.
938 nm Nd-Doped High Power Cladding Pumped Fiber Amplifier (2002)

2.1W of 938nm light has been produced in an Nd{sup 3+} doped fiber amplifier. Wavelength dependent bend losses can be employed to minimize 1088nm amplified spontaneous emission giving the optical fiber a distinct advantage over bulk media.
The impact of conversion on the risk of major complication following laparoscopic colonic surgery: an international, multicentre prospective audit (2018)

Abstract Background Laparoscopy has now been implemented as a standard of care for elective colonic resection around the world. During the adoption period, studies showed that conversion may be detrimental to patients, with poorer outcomes than both laparoscopic completed or planned open surgery. The primary aim of this study was to determine whether laparoscopic conversion was associated with a higher major complication rate than planned open surgery in contemporary, international practice. Methods Combined analysis of the European Society of Coloproctology 2017 and 2015 audits. Patients were included if they underwent elective resection of a colonic segment from the caecum to the rectosigmoid junction with primary anastomosis. The primary outcome measure was the 30‐day major complication rate, defined as Clavien‐Dindo grade III ‐V. Results Of 3980 patients, 64% (2561/3980) underwent laparoscopic surgery and a laparoscopic conversion rate of 14% (359/2561). The major complication rate was highest after open surgery (laparoscopic 7.4%, converted 9.7%, open 11.6%, P &lt; 0.001). After case mix adjustment in a multilevel model, only planned open (and not laparoscopic converted) surgery was associated with increased major complications in comparison to laparoscopic surgery ( OR 1.64, 1.27–2.11, P &lt; 0.001). Conclusions Appropriate laparoscopic conversion should not be considered a treatment failure in modern practice. Conversion does not appear to place patients at increased risk of complications vs planned open surgery, supporting broadening of selection criteria for attempted laparoscopy in elective colonic resection.
Observations of Different Triplet Conformations in Time-Resolved Infrared Spectra of Alkyl Phenylglyoxylates (2002)

Two different conformations of the triplet state of alkyl phenylglyoxylates were observed by means of time-resolved step-scan FT-IR spectroscopy. The amplitude of the peak corresponding to the sterically hindered conformation decreases as the size of the alkyl group increases. Both conformations exhibit similar reactivity in intermolecular hydrogen abstraction, but only one of them undergoes Norrish Type II photoelimination.
ChemInform Abstract: Benzospiropyrans as Photochromic and/or Thermochromic Photoinitiators. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Evaluation of the Safety of Neauvia Stimulate Injectable Product in Patients with Autoimmune Thyroid Diseases Based on Histopathological Examinations and Retrospective Analysis of Medical Records (2023)

The aim of this study was to test the effect of hyaluronic acid cross-linked with polyethylene glycol containing micronized portions of calcium hydroxyapatite (Neauvia Stimulate) on both local tissue and systemic consequences, which are crucial from the perspective of long-term safety, in patients suffering from Hashimoto's disease. This most common autoimmune disease is a frequently mentioned contraindication to the use of fillers based on hyaluronic acid as well as biostimulants based on calcium hydroxyapatite. Broad-spectrum aspects of histopathology were analyzed to identify key features of inflammatory infiltration before the procedure and 5, 21, and 150 days after the procedure. A statistically significant effect on the reduction of the intensity of the inflammatory infiltration in the tissue in relation to the state before the procedure was demonstrated, combined with a reduction in the occurrence of both antigen-recognizing (CD4) and cytotoxic (CD8) T lymphocytes. With complete statistical certainty, it was demonstrated that the treatment with Neauvia Stimulate had no effect on the levels of these antibodies. All this corresponds with the risk analysis that showed no alarming symptoms during the time of observation. The choice of hyaluronic acid fillers cross-linked with polyethylene glycol should be considered justified and safe in the case of patients suffering from Hashimoto's disease.
Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors (2015)

Selective inhibition of KDAC isoforms while maintaining potency remains a challenge. Using the largazole macrocyclic depsipeptide structure as a starting point for developing new KDACIs with increased selectivity, a combination of four different simplified largazole analogue (SLA) scaffolds with diverse zinc-binding groups (for a total of 60 compounds) were designed, synthesized, and evaluated against class I KDACs 1, 3, and 8, and class II KDAC6. Experimental evidence as well as molecular docking poses converged to establish the cyclic tetrapeptides (CTPs) as the primary determinant of both potency and selectivity by influencing the correct alignment of the zinc-binding group in the KDAC active site, providing a further basis for developing new KDACIs of higher isoform selectivity and potency.
Polarization diversity in MIMO radio channels: experimental validation of a stochastic model and performance assessment (2002)

A stochastic MIMO radio channel considering (i) polarization diversity and (ii) unbalanced branch power ratio (BPR) is being validated by comparing Monte-Carlo simulations and experimental results using the eigenanalysis as benchmark. Based on results generated by the model, the influence of the BPR on the power gain of the parallel subchannels is presented.
<title>Spectroscopy and nonlinear optical absorption of bis(diphenylamino) diphenyl polyenes</title> (1999)

The spectroscopy and nonlinear absorption of bis(diphenylamino) diphenyl polyenes have been studied in octane and dichloromethane solvents. The amines exhibit high fluorescence quantum yield and two photon excited emission. Two photon absorption cross section, (sigma) <SUB>2</SUB>, was measured by Z-scan experiments. Strong two photon absorption is indicated by high values for (sigma) <SUB>2</SUB>. Solvent has strong influence in the measurement of (sigma) <SUB>2</SUB> values.
ChemInform Abstract: Diastereoselective Radical Mediated Alkylation of a Chiral Glycolic Acid Derivative. (2011)

Abstract The presented reaction of (I) to compounds (III) and (IV) is an example where increasing the exothermicity leads to an enhancement of stereoselectivity.
CXCL10-CXCR3 Enhances the Development of Neutrophil-mediated Fulminant Lung Injury of Viral and Nonviral Origin (2012)

CXCL10-CXCR3 signaling appears to be a critical factor for the exacerbation of the pathology of ARDS. Thus, the CXCL10-CXCR3 axis could represent a prime therapeutic target in the treatment of the acute phase of ARDS of nonviral and viral origins.
The future of simulation: a field of dreams (2006)

Due to the enormous complexity of computer systems, researchers use simulators to model system behavior and generate quantitative estimates of expected performance. Researchers also use simulators to model and assess the efficacy of future enhancements and novel systems. Arguably the most important tools available to computer architecture researchers, simulators offer a balance of cost, timeliness, and flexibility. Improving the infrastructure, benchmarking, and methodology of simulation - the dominant computer performance evaluation method - results in higher efficiency and let architects gain more insight into processor behavior. For these reasons, architecture researchers have increasingly relied on simulators
Type VI collagen expression is upregulated in the early events of chondrocyte differentiation (1993)

Dedifferentiated chondrocytes cultured adherent to the substratum proliferate and synthesize large amounts of type I collagen but when transferred to suspension culture they decrease proliferation, resume the chondrogenic phenotype and the synthesis of type II collagen, and continue their maturation to hypertrophic chondrocyte (Castagnola et al., 1986, J. Cell Biol. 102, 2310-2317). In this report, we describe the developmentally regulated expression of type VI collagen in vitro in differentiating avian chondrocytes. Type VI collagen mRNA is barely detectable in dedifferentiated chondrocytes as long as the attachment to the substratum is maintained, but increases very rapidly upon passage of the cells into suspension culture reaching a peak after 48 hours and declining after 5-6 days of suspension culture. The first evidence of a rise in the mRNA steady-state levels is obtained already at 6 hours for the alpha 3(VI) chain. Immunoprecipitation of metabolically labeled cells with type VI collagen antibodies reveals that the early mRNA rise is paralleled by an increased secretion of type VI collagen in cell media. Induction of type VI collagen is not the consequence of trypsin treatment of dedifferentiated cells since exposure to the actin-disrupting drug cytochalasin or detachment of the cells by mechanical procedures has similar effects. In 13-day-old chicken embryo tibiae, where the full spectrum of the chondrogenic differentiation process is represented, expression of type VI collagen is restricted to the articular cartilage where chondrocytes developmental stage is comparable to stage I (high levels of type II collagen expression).(ABSTRACT TRUNCATED AT 250 WORDS)
Squalenoylated Nanoparticle Pro-Drugs of Adjuvant Antitumor 11α-Hydroxyecdysteroid 2,3-Acetonides Act as Cytoprotective Agents Against Doxorubicin and Paclitaxel (2020)

Several ecdysteroid acetonides act as adjuvant chemo-sensitizing agents against various cancer cell lines, and they can be formulated to self-assembling nanoparticle (NP) pro-drugs through a hydrolysable conjugation with squalene. In the bloodstream such squalenoylated nanoparticles dissolve into low-density lipoprotein (LDL) that allows targeting tissues containing high levels of LDL-receptors. In this work, ajugasterone C 2,3;20,22-diacetonide (<b>3</b>) and 11α-hydroxypoststerone 2,3-acetonide (<b>4</b>) were squalenoylated to obtain two new ecdysteroid pro-drugs (<b>6</b> and <b>7</b>) and their nano-assemblies (<b>6<sub>NP</sub></b> and <b>7<sub>NP</sub></b> ). A complete NMR signal assignment of <b>6</b> and <b>7</b> was achieved. Interaction of compounds <b>3</b> and <b>4</b> with chemotherapeutics was studied by the Chou-Talalay method. Compound <b>3</b> showed strong synergism with doxorubicin on a multi-drug resistant lymphoma cell line. In contrast, its nanoassembly <b>6<sub>NP</sub></b> significantly decreased the cytotoxicity of doxorubicin on these MDR cells, strongly suggesting that at least the 2,3-acetonide group was cleaved by the acidic pH of lysosomes after endocytosis of the prodrug. Further, compound <b>4</b> acted in strong antagonism with paclitaxel on MCF-7 cells and its nanoassemby <b>7<sub>NP</sub></b> also protected MCF-7 cells from the effect of paclitaxel. Our results suggest that acid-resistant A-ring substitution would be crucial to design adjuvant antitumor squalenoylated ecdysteroid prodrugs. Additionally, our results may be considered as a serendipitous discovery of a novel way to deliver cytoprotective, adaptogen ecdysteroids to healthy tissues with upregulated LDL-R.
Graphene: Spongy Graphene as a Highly Efficient and Recyclable Sorbent for Oils and Organic Solvents (Adv. Funct. Mater. 21/2012) (2012)

Spongy graphene (SG), a nanoporous material with a high surface area, is used as a versatile and recyclable sorber. On page 4421, Litao Sun, Rodney S. Ruoff, and co-workers report that SG shows highly efficient absorption of petroleum products, fats, and toxic solvents and can be regenerated by heat treatment, yielding almost full release of the adsorbates. SG shows a widespread potential for applications in industry and environmental protection.
An improved method of plant megabase DNA isolation in agarose microbeads suitable for physical mapping and YAC cloning (1993)

The isolation of high quality megabase DNA from plant cells that is susceptible to a variety of molecular reagents is a critical first step in the physical analysis of complex genomes. A method for the isolation of such DNA by encapsulating plant protoplasts in agarose microbeads is presented. In comparison with the conventional agarose plug method, microbeads provide a dramatic increase in the surface area yielding megabase DNA that can be treated essentially as an aqueous DNA solution. Examples of the utility of DNA prepared by this technique for physical mapping, partial restriction enzyme digestion and cloning of large inserts as YACs are presented.
Synthesis, Stereochemical and Photophysical Properties of Functionalized Thiahelicenes (2022)

We report on the synthesis of a novel class of functionalized thia[6]helicenes and a thia[5]helicene, containing a benzothiophene unit and a second heteroatom embedded in the helix (i.e., nitrogen and oxygen) or a pyrene or a spirobifluorene moiety. These systems are obtained through straightforward and general procedures that involve: (i) palladium-catalyzed annulation of iodo-atropoisomers with internal alkynes and (ii) Suzuki coupling of iodo-atropoisomers with phenyl boronic acid followed by a Mallory-type reaction. Both experimental and theoretical studies on the configurational stability of some selected thia[6]helicenes confirmed their stability toward racemization at room temperature, while the pyrene-based thia[5]helicene was found to be unstable. Moreover, the configuration assignment for one representative thiahelicene was established through the comparison between experimental and theoretical circular dichroism (CD) spectra. A systematic study of the photophysical properties of both thiahelicenes and the corresponding atropoisomers has been carried out to provide a complete overview on the new molecules proposed in this work. The obtained data showed regular trends in all the thiahelicene series with spectroscopic traits in line with those previously observed for similar heterohelicenes.
A Polymer Electrolyte for Operation at Temperatures up to 200°C (1994)

In developing advanced fuel cells and other electrochemical reactors, it is desirable to combine the advantages of solid polymer electrolytes with the enhanced catalytic activity associated with temperatures above 100 C. This will require polymer electrolytes which retain high ionic conductivity at temperatures above the boiling point of water. One possibility is to equilibrate standard perfluorosulfonic acid polymer electrolytes such as Nafion, with a high boiling point Bronsted base such as phosphoric acid. The Nafion/H[sub 3]PO[sub 4] electrolyte has been evaluated with respect to water content, ionic conductivity and transport of oxygen, and methanol vapor. The results show that at elevated temperatures reasonably high conductivity (>0.05 [Omega][sup [minus]1] cm[sup [minus]1]) can be obtained. Methanol permeability is shown to be proportional to the methanol vapor activity and thus decreases with increasing temperature for a given partial pressure. Comparisons and distinctions between this electrolyte and pure phosphoric acid are also considered.
Primary Current Generation for a Contactless Power Transfer System Using Free Oscillation and Energy Injection Control (2011)

This paper utilizes free oscillation and energy injection principles to generate and control the high frequency current in the primary track of a contactless power transfer system. Here the primary power inverter maintains natural resonance while ensuring near constant current magnitude in the primary track as required for multiple independent loads. Such energy injection controllers exhibit low switching frequency and achieve ZCS (Zero Current Switching) by detecting the high frequency current, thus the switching stress, power losses and EMI of the inverter are low. An example full bridge topology is investigated for a contactless power transfer system with multiple pickups. Theoretical analysis, simulation and experimental results show that the proposed system has a fast and smooth start-up transient response. The output track current is fully controllable with a sufficiently good waveform for contactless power transfer applications.
Study of ultra-precision diamond turning of a microlens array with a fast tool servo system (2006)

A Microlens array is a critical component for optimizing display functions. With the increasing usage of display systems in photonic products nowadays, more attention is being paid to the research and development of fabrication technology for microlens arrays. Ultra-precision machining with a fast tool servo (FTS) is one of the leading methodologies for fabrication of high-quality optical microstructural surfaces. FTS is an independently operated positioning device, which provides an indispensable solution for machining optical microstructures with sub-micrometer form accuracy and nanometric surface finish, without the need for any subsequent post processing. The surface quality of an FTS machined surface depends largely on the selection of cutting conditions. However, the achievement of ultra-precision surface finishing depends greatly on the experience and skill of the machine operators. Determination of optimal cutting conditions can stabilize the quality of the fabricated microlens array. In this paper, the effect of cutting conditions such as depth of cut, feed rate, spindle speed and surface speed are investigated; and optimal surface roughness and surface profiles in ultra-precision machining with FTS can be observed.
Correction: Corrigendum: Temporary-tattoo for long-term high fidelity biopotential recordings (2017)

Scientific Reports 6: Article number: 25727; published online: 12 May 2016; updated: 23 January 2017 The authors neglected to cite a previously-published related paper which reports the use of PEDOT:PSS ink-jet printing to realize nanosheets for skin-contact applications. This is listed below as reference 1, and should appear in the introduction as below:
Accelerated recycling of transferrin receptor in Theileria-transformed B cells (2005)

We found that phoshatidylinositol-3 kinase (PI3-K) markedly contributes to the increased surface expression of bovine transferrin receptor (TfR) on Theileria-infected lymphocytes. We observed that all aspects of TfR turnover are upregulated in parasitized B cells and we were able to detect TfR colocalizing with EEA1 (early endosome antigen 1) and Rab11 at the ultrastructure level in Theileria-infected B cells. We demonstrated recycling of TfR through Rab5- and Rab11-positive compartments by transfection of dominant negative guanosine diphosphate (GDP)-on mutants of the GTPases. Therefore, in Theileria-transformed B cells constitutive PI3-K activity leads to accelerated TfR recycling through Rab5- and Rab11-positive compartments.