gebhart/patrepeval huggingface dataset:
An Electrostatic Pest Exclusion Strategy for Greenhouse Tomato Cultivation (2022)

Electrostatic devices generating an electric field (EF) are promising tools for greenhouse tomato cultivation. In these devices, an EF is generated in the space surrounding an insulated conductor (IC) that is charged by a voltage generator. Thus, a physical force is exerted on any insect that enters the EF, as a negatively charged IC (NC-IC) pushes a negative charge (free electrons) out of the insect body. The insect is polarized positively to be attracted to the NC-IC, and a grounded metal net (G-MN) repels the insect. This dual function of the apparatus (insect capture and repulsion) is the core of the electrostatic pest-exclusion strategy. In this study, we applied various innovative EF-based devices to evaluate their efficacy in greenhouse tomato cultivation. Our objective was to determine the optimal apparatus for simple, inexpensive construction by greenhouse workers. The results of this study will contribute to the development of sustainable pest-management protocols in greenhouse horticulture.
Comparative Investigation of Configuration of Brakes in Passive-type Force Display System (2020)

In recent years, force display systems that supports rehabilitation of paralyzed patients have been developed and the effectiveness has been clarified. Force displays are classified into passive type and active type. A passive-type system using brakes has less risk of harming a user compared with an active-type system using motors. Therefore, passive-type system is safe and low cost, and can be used at home. In this paper, we develop a planar 2-DOF passive-type force display system with redundant powder brakes whose characteristics are experimentally obtained. Four configurations of brakes are illustrated. The tracing experiments are conducted to clarify the difference of haptic performance of them.
Validity of bipolar disorder hospital discharge diagnoses: file review and multiple register linkage in Sweden (2011)

Our findings suggest that DSM-IV-TR bipolar disorder caseness based on two inpatient episodes with a bipolar disorder diagnosis is sufficiently sensitive and specific to be used in further epidemiological study of bipolar disorder.
miR-122-SOCS1-JAK2 axis regulates allergic inflammation and allergic inflammation-promoted cellular interactions (2017)

The regulatory role of suppressor of cytokine signaling 1 (SOCS1) in inflammation has been reported. However, its role in allergic inflammation has not been previously reported. SOCS1 mediated <i>in vitro</i> and <i>in vivo</i> allergic inflammation. Histone deacetylase-3 (HDAC3), a mediator of allergic inflammation, interacted with SOCS1, and miR-384 inhibitor, a positive regulator of HDAC3, induced features of allergic inflammation in an SOCS1-dependent manner. miRNA array analysis showed that the expression of miR-122 was decreased by antigen-stimulation. TargetScan analysis predicted the binding of miR-122 to the 3'-UTR of SOCS1. miR-122 inhibitor induced <i>in vitro</i> and <i>in vivo</i> allergic features in SOCS1-dependent manner. SOCS1 was necessary for allergic inflammation-promoted enhanced tumorigenic and metastatic potential of cancer cells. SOCS1 and miR-122 regulated cellular interactions involving cancer cells, mast cells and macrophages during allergic inflammation. SOCS1 mimetic peptide, D-T-H-F-R-T-F-R-S-H-S-D-Y-R-R-I, inhibited <i>in vitro</i> and <i>in vivo</i> allergic inflammation, allergic inflammation-promoted enhanced tumorigenic and metastatic potential of cancer cells, and cellular interactions during allergic inflammation. Janus kinase 2 (JAK2) exhibited binding to SOCS1 mimetic peptide and mediated allergic inflammation. Transforming growth factor- Δ1 (TGF-Δ1) was decreased during allergic inflammation and showed an anti-allergic effect. SOCS1 and JAK2 regulated the production of anti-allergic TGF-Δ1. Taken together, our results show that miR-122-SOCS1 feedback loop can be employed as a target for the development of anti-allergic and anti-cancer drugs.
Supplementary Figures 1 - 2 from Molecular Photoacoustic Imaging of Follicular Thyroid Carcinoma (2023)

&lt;p&gt;PDF file - 370K, Characterization of the probes: HPLC, MS and absorbance data&lt;/p&gt;
Optoelectronic relational-database interface to parallel-access optical memories (1993)

Database management is one of the most common applications of computers and their associated storage.
Joint Speech Recognition and Speaker Diarization via Sequence\n Transduction (2019)

Speech applications dealing with conversations require not only recognizing\nthe spoken words, but also determining who spoke when. The task of assigning\nwords to speakers is typically addressed by merging the outputs of two separate\nsystems, namely, an automatic speech recognition (ASR) system and a speaker\ndiarization (SD) system. The two systems are trained independently with\ndifferent objective functions. Often the SD systems operate directly on the\nacoustics and are not constrained to respect word boundaries and this\ndeficiency is overcome in an ad hoc manner. Motivated by recent advances in\nsequence to sequence learning, we propose a novel approach to tackle the two\ntasks by a joint ASR and SD system using a recurrent neural network transducer.\nOur approach utilizes both linguistic and acoustic cues to infer speaker roles,\nas opposed to typical SD systems, which only use acoustic cues. We evaluated\nthe performance of our approach on a large corpus of medical conversations\nbetween physicians and patients. Compared to a competitive conventional\nbaseline, our approach improves word-level diarization error rate from 15.8% to\n2.2%.\n
malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication (2017)

Basic science holds enormous power for revealing the biological mechanisms of disease and, in turn, paving the way toward new, effective interventions. Recognizing this power, the 2011 Research Agenda for Malaria Eradication included key priorities in fundamental research that, if attained, could help accelerate progress toward disease elimination and eradication. The Malaria Eradication Research Agenda (malERA) Consultative Panel on Basic Science and Enabling Technologies reviewed the progress, continuing challenges, and major opportunities for future research. The recommendations come from a literature of published and unpublished materials and the deliberations of the malERA Refresh Consultative Panel. These areas span multiple aspects of the Plasmodium life cycle in both the human host and the Anopheles vector and include critical, unanswered questions about parasite transmission, human infection in the liver, asexual-stage biology, and malaria persistence. We believe an integrated approach encompassing human immunology, parasitology, and entomology, and harnessing new and emerging biomedical technologies offers the best path toward addressing these questions and, ultimately, lowering the worldwide burden of malaria.
Water/fat‐resolved whole‐heart Dixon coronary MRA: An initial comparison (2013)

Dual-echo Dixon can help to improve whole-heart CMRA image quality significantly. The additional whole-heart fat information delivered by this approach can support a number of new clinical studies addressing the diagnostic and the predictive value of intramyocardial and extramyocardial fatty deposits.
Nominal Versus Actual Spatial Resolution: Comparison of Directivity and Frequency-Dependent Effective Sensitive Element Size for Membrane, Needle, Capsule, and Fiber-Optic Hydrophones (2022)

Frequency-dependent effective sensitive element radius [Formula: see text] is a key parameter for elucidating physical mechanisms of hydrophone operation. In addition, it is essential to know [Formula: see text] to correct for hydrophone output voltage reduction due to spatial averaging across the hydrophone sensitive element surface. At low frequencies, [Formula: see text] is greater than geometrical sensitive element radius a<sub>g</sub> . Consequently, at low frequencies, investigators can overrate their hydrophone spatial resolution. Empirical models for [Formula: see text] for membrane, needle, and fiber-optic hydrophones have been obtained previously. In this article, an empirical model for [Formula: see text] for capsule hydrophones is presented, so that models are now available for the four most common hydrophone types used in biomedical ultrasound. The [Formula: see text] value was estimated from directivity measurements (over the range from 1 to 20 MHz) for five capsule hydrophones (three with [Formula: see text] and two with [Formula: see text]). The results suggest that capsule hydrophones behave according to a "rigid piston" model for k a <sub>g</sub> ≥ 0.7 ( k = 2π /wavelength). Comparing the four hydrophone types, the low-frequency discrepancy between [Formula: see text] and a<sub>g</sub> was found to be greatest for membrane hydrophones, followed by capsule hydrophones, and smallest for needle and fiber-optic hydrophones. Empirical models for [Formula: see text] are helpful for choosing an appropriate hydrophone for an experiment and for correcting for spatial averaging (over the sensitive element surface) in pressure and beamwidth measurements. When reporting hydrophone-based pressure measurements, investigators should specify [Formula: see text] at the center frequency (which may be estimated from the models presented here) in addition to a<sub>g</sub> .
The Arabidopsis thaliana pan-NLRome (2019)

Abstract Disease is both among the most important selection pressures in nature and among the main causes of yield loss in agriculture. In plants, resistance to disease is often conferred by Nucleotide-binding Leucine-rich Repeat (NLR) proteins. These proteins function as intracellular immune receptors that recognize pathogen proteins and their effects on the plant. Consistent with evolutionarily dynamic interactions between plants and pathogens, NLRs are known to be encoded by one of the most variable gene families in plants, but the true extent of intraspecific NLR diversity has been unclear. Here, we define the majority of the Arabidopsis thaliana species-wide “NLRome”. From NLR sequence enrichment and long-read sequencing of 65 diverse A. thaliana accessions, we infer that the pan-NLRome saturates with approximately 40 accessions. Despite the high diversity of NLRs, half of the pan-NLRome is present in most accessions. We chart the architectural diversity of NLR proteins, identify novel architectures, and quantify the selective forces that act on specific NLRs, domains, and positions. Our study provides a blueprint for defining the pan-NLRome of plant species.
Figure S5 from AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x<sub>L</sub>, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia (2023)

&lt;p&gt;Figure S5&lt;/p&gt;
Dynamic Print Mode Control for Inkjet Printing (2001)

We introduce a novel printing scheme that allows arbitrarily shaped regions in a document to be printed using different modes. Our implementation first segments the document into two basic modes: one pass and four pass. The one pass mode results in greater print speed but has lower quality, whereas the four pass mode results in greater quality but lower print speed. Typically, the one pass mode is more suitable for text and graphics, while the four pass mode is more suitable for continuous tone pictures.We demonstrate our method using a Lexmark Z52 print engine controlled by a Texas Instruments C6211 DSP. The resulting dynamic print mode control system can be used to continuously trade-off print speed for print quality, or to optimize print quality at a desired print speed.
AL001 Blocks the Sortilin/PGRN Interaction and is a Potential Therapy for FTD-GRN (4422) (2021)

AL001 blocks the Sortilin/PGRN interaction and is a potential therapy for FTD-GRN
Development of Cancer Immunotherapies Based on Identification of the Genes Encoding Cancer Regression Antigens (1996)

Tumor-infiltrating lymphocytes (TILs) have been grown from patients with metastatic melanoma and administered to the autologous patients to identify those TIL populations capable of mediating tumor regression. These TILs have been used to clone the genes that encode melanoma antigens. With the use of this strategy, we have identified six different genes encoding antigens restricted by multiple HLA alleles that appear to be related to tumor regression in patients. These antigens are now being used to develop immunization approaches for the treatment of patients with metastatic melanoma. The availability of genes encoding unique cancer antigens is opening new possibilities for the development of immunotherapies for the treatment of patients with cancer.
Thermal Isomerization of N-Bridged Cobalt Corrole Complexes through a Transiently Formed Axial Carbenoid (2011)

The reaction of cobalt(III) octaethylcorrole (CoOEC) with ethyl diazoacetate (EDA) under a nitrogen atmosphere led to the formation of bridged complexes with the carbene moiety inserted into one of the cobalt−nitrogen bonds. The bridged complexes underwent unique thermal isomerization, presumably via the transiently formed axial carbene complex. One of the thermodynamic isomers was characterized by 1H NMR and mass spectroscopic methods.
Temperature Dependence of Bulk Viscosity in Edible Oils using Acoustic Spectroscopy (2017)

When ultrasound waves are applied to a compressible Newtonian fluid, bulk viscosity plays an important parameter to cause attenuation. Ultrasound spectroscopy is an important technique to characterise and determine the physico-chemical properties of many food components because it is a non-invasive, non-destructive, easy and accurate technique. The aim of this study was to find the bulk viscosity of three brands of sunflower and extra-virgin olive oil by using the Navier's-Stoke equation across a temperature range of 5C to 40C and to test the hypothesis that there is a significant difference in the value of bulk viscosity between the different brands of sunflower and olive oil used. The value of bulk viscosity was not found to be constant over the operating frequency range of 12-100 MHz, which suggested edible oils are non-Newtonian fluids. Also, no significant statistical difference of bulk viscosity values was found between different brands of the same oil (p 0.05). This shows bulk viscosity is not affected by small compositional variations. Acoustic spectroscopy is increasingly being used to characterise food materials. More studies on bulk viscosity must be employed in order to be able to utilise this technology to its full strength.
<title>Optimization of GBCD by combining laser surface melting with annealing heat treatment</title> (2004)

LSM and annealing heat treatment on 304 stainless steel resulted in microstructures with high frequency of low &sum; CSL boundaries defined by the coincidence site lattice (CSL) model, especially, twin boundaries (&sum;3). The maximum frequency of the low &sum; CSL boundaries could be 88.6% under optimal processing conditions: 947&deg;C and 28h. The high fraction of the low-&sum; CSL boundaries led to a high corrosion resistance to intergranular corrosion.
Revisiting Folded Forms with Digital Fabrication (2019)

This paper discusses the potential of emerging digital fabrication techniques to produce material-efficient thin folded concrete structures. Although in the 50s and 60s folded structures provided a common optimal solution for spanning large distances without additional vertical supports, today, the number of these projects decreased significantly due to their complicated formworks and labour-intensive realization. Digital fabrication methods for concrete hold the promise to efficiently produce intricate folded mass-customized shapes with enhanced load-bearing capacity. This paper focuses on a robotic slip-forming process, Smart Dynamic Casting (SDC), to produce various thin-walled folded concrete elements with the same formwork providing smooth surface finish and gradual variations along the height. An empirical research methodology was applied to evaluate the fabrication feasibility of digitally designed thin folded geometries with one-to-one scale prototypes. Despite the discovered design limitations due to fabrication and material constraints, the exploration led to a new promising research direction, termed 'Digital Casting'.
TEL and KIP1 define the smallest region of deletions on 12p13 in hematopoietic malignancies (1995)

Unbalanced translocations as well as interstitial deletions of the short arm of chromosome 12 [del(12p)] are found as recurring chromosomal changes in a broad spectrum of hematopoietic malignancies. These changes result in the hemizygous deletion of genetic material from 12p. We mapped a yeast artificial chromosome containing the TEL gene, a cosmid contig containing part of TEL and a P1 contig containing the KIP1 gene to 12p13. These probes were used for fluorescence in situ hybridization to analyze samples from 47 patients with various hematologic malignancies who had unbalanced translocations (25 patients) leading to loss of 12p or deletions (22 patients) involving 12p13. The patients had acute lymphoblastic leukemia (8 cases), myelodysplastic syndrome (MDS; 11 cases), acute myeloid leukemia (AML; 10 cases), myeloproliferative disorders (4 cases), therapy-related MDS or AML (7 cases), non-Hodgkin's lymphoma (2 cases), and other hematopoietic malignancies (5 cases). All three probes were hemizygously detected in 26 cases and were completely retained in only 9 cases. In 12 cases probes for one of the two genes were deleted, allowing us to map the smallest region of overlap of these deletions to a small genomic region that is bordered on the telomeric side by the TEL gene and on the centromeric side by KIP1. The genomic distance between TEL and KIP1 is estimated to be about 1 to 2 Mbp.
Measurements of Protein Structure and Noncovalent Interactions by Time-of-Flight Mass Spectrometry with Orthogonal Ion Injection (2000)

Genomic sequences are becoming available with increasing speed as a result of the advances in gene technology. Nevertheless, both covalent and noncovalent modifications can occur in the corresponding protein sequence before the protein is fully functional, so it is important to know the actual protein sequence to understand its function [1, 2]. It is equally important to determine the higher order protein structure, and its interaction with other biological components. Noncovalent interactions of this type play a key role in molecular recognition phenomena such as enzyme-substrate interaction, receptor-ligand binding, formation of oligomeric proteins, assembly of transcription factors, and formation of cellular structures themselves [3–4].
Large-scale chemical-genetics yields new Mycobacterium tuberculosis inhibitor classes (2018)

New antibiotics are needed to combat rising resistance, with new Mycobacterium tuberculosis (Mtb) drugs of highest priority. Conventional whole-cell and biochemical antibiotic screens have failed. We developed a novel strategy termed PROSPECT (PRimary screening Of Strains to Prioritize Expanded Chemistry and Targets) in which we screen compounds against pools of strains depleted for essential bacterial targets. We engineered strains targeting 474 Mtb essential genes and screened pools of 100-150 strains against activity-enriched and unbiased compounds libraries, measuring &gt; 8.5-million chemical-genetic interactions. Primary screens identified &gt;10-fold more hits than screening wild-type Mtb alone, with chemical-genetic interactions providing immediate, direct target insight. We identified &gt; 40 novel compounds targeting DNA gyrase, cell wall, tryptophan, folate biosynthesis, and RNA polymerase, as well as inhibitors of a novel target EfpA. Chemical optimization yielded EfpA inhibitors with potent wild-type activity, thus demonstrating PROSPECT’s ability to yield inhibitors against novel targets which would have eluded conventional drug discovery.
Radiative and nonradiative excitonic transitions in nonpolar (1120) and polar (0001) and (0001) ZnO epilayers (2004)

Polarized optical reflectance and photoreflectance spectra of an out-plane nonpolar (112̄0) ZnO epilayer grown by laser molecular-beam epitaxy exhibited anisotropic exciton resonance structures according to the polarization selection rules for anisotropically strained hexagonal material. Consistently, the electric field component of its excitonic photoluminescence (PL) peak was polarized perpendicular to the [0001] axis. Different from the case for GaN, nonradiative PL lifetime at 293 K and the S parameter, which is a measure of Zn vacancy-related defect density obtained by positron annihilation spectroscopy, of the (112̄0) ZnO were comparable to those of state-of-the-art polar (0001̄) and (0001) epilayers. Since the polar epilayers exhibited pronounced exciton–polariton emissions, the negligible impact of growth direction on the defect incorporation suggests a potential use of epitaxial (112̄0) ZnO as polarization-sensitive optoelectronic devices operating in ultraviolet spectral regions.
Wideband parametric processing with 1-dB bandwidth of 40nm using dispersion stable PM-HNLF (2014)

We confirm the widest parametric processing bandwidth of a dispersion stable polarisation maintaining (PM) highly nonlinear fibre (HNLF) among PM-HNLFs. A wavelength conversion and a quasi-phase-matched FOPA with gain of 19 dB have 1-dB bandwidth of 40 nm.
Wheat germ agglutinin inhibits thrombin‐induced rises in cytosolic free calcium and prostacyclin synthesis by human umbilical vein endothelial cells (1988)

To characterize the endothelial cell surface membrane glycoproteins that mediate thrombin stimulation of PGI2 synthesis by human umbilical vein endothelial cells (HUVEC), HUVEC were stimulated with thrombin in the presence or absence of different lectins. Of the lectins tested, only wheat germ agglutinin (WGA) inhibited thrombin-induced rises in cytosolic free calcium [( Ca2+]i), measured using Quin 2-loaded HUVEC and PGI2 production measured by radioimmunoassay. However, WGA by itself had no influence on baseline [Ca2+]i or PGI2 production and did not inhibit histamine-induced rises in [Ca2+]i. The inhibition of thrombin-induced rises in [Ca2+]i and PGI2 production by WGA was dose dependent, with half-maximal inhibition occurring at 2 micrograms/ml. WGA also inhibited thrombin-induced release of 3H-arachidonic acid. These effects of WGA were reversed by N-acetyl-glucosamine (GlcNAc) and N-acetyl-neuraminic acid, which bind specifically to WGA, but not by unrelated sugars. Succinylated WGA (succ-WGA), a chemically modified derivative of WGA that binds to GlcNAc but, unlike native WGA, not to sialoglycoproteins, did not inhibit thrombin-induced rises in [Ca2+]i and PGI2 production. These results suggest that thrombin induces rises in [Ca2+]i and PGI2 production by interacting with an endothelial surface membrane sialoglycoprotein.