gebhart/patrepeval huggingface dataset:
THE COMPUTER-AIDED ANALYTICAL SYSTEM FOR THE GEOTECHNICAL CHARACTERIZATION PROBLEMS. PROCEEDINGS OF THE SIXTH INTERNATIONAL CONFERENCE ON NUMERICAL METHODS IN GEOMECHANICS, 11-15 APRIL 1988, INNSBRUCK, AUSTRIA. VOLUMES 1 - 3 (1988)

This paper presents on-going research into the development of computer-aided design and analytical system for geotechnical characterization problems. The system is currently being evolved on the microvax hardware configuration using the graphic kernal system in FORTRAN 77 language. The main goal is to set up the fully interactive analytical system in which the unknown parameters concerning (1) geometry, (2) material constitutive law and (3) loading system are determined through the use of a finite element method (fem) program and appropriate optimization procedure. Such system characterization analysis is based on the concept of minimizing the discrepancy between the numerical prediction and the actual behaviour of the geotechnical system and therefore requires, as the standard procedure, the in-situ field measurement data to define the suitable error function. Previous studies have proved that such a system is not only a feasible project but also has great potential to improve the monitoring system of geotechnical engineering practices. (Author/TRRL)
Cancer-associated retinopathy in a 66 years-old woman with small-cell lung cancer (2015)

<b>Introduction:</b> Paraneoplastic syndromes are usually associated to small-cell lung carcinomas (SCLC) and are frequently due to the production of auto-antibodies. We report the case of a rare paraneoplastic syndrome, the Cancer-Associated Retinopathy (CAR) syndrome. <b>Case report:</b> A 66 years-old woman consulted her ophtalmologist for rapid-onset bilateral visual loss, nyctalopia and metamorphopsia. The visual acuity was 6/10 and 2/10 in the right and left eye, respectively. Diagnosis was an auto-immune retinopathy, with the presence of anti-recoverin antibody. The chest CT-scan revealed a pulmonary nodule in the right upper lobe. After complete evaluation, a SCLC with CAR syndrome was diagnosed. The patient underwent concomitant radiochemotherapy by Cisplatin/Etoposid, with a complete response at the end of the treatment course. Initially, the retinopathy was treated by a 3-day course of high-dose I.V. corticosteroid (500mg methylprednisolone per day) followed by oral prednisone at 1mg.kg daily and slow decrease. The CAR syndrome relapsed at 32 month of treatment without cancer relapse, and required to re-increase corticosteroid treatment. <b>Review of literature:</b> In a series of 209 patients with Cancer-Associated Retinopathy and Melanoma-Associated Retinopathy (MAR), Adamus et al. found that cancer associated with CAR syndrome were mainly breast (31%), lung (16%) and hematological malignancies (15%). In 31 lung cancer, 15 patients had auto-antibodies, most frequently anti-recoverin. <b>Conclusion:</b> CAR syndrome is a rare entity, which led, in this case, to the diagnosis of a limited SCLC. The CAR syndrome can relapse independently of cancer evolution.
Monofunctionalization with dextrans endows cell‐penetrative properties to proteins (2019)

Dextrans have proven to be a widely useful class of polysaccharides, with applications ranging from antithrombotic agents to enhancers of vaccine stability. We have examined an unprecedented property of dextrans: the capacity to convey cargo into the cytosol. Mono‐functionalized dextran–flourogenic probe and dextran–protein conjugates were prepared to assess the ability of dextran to mediate cellular delivery. We show that dextran conjugates are taken up in an energy‐dependent process culminating in cytosolic access. Several cell types were examined, indicating the generality of this uptake pathway. These observations motivated the preparation of dextran–cytochrome C conjugates. Release of cytochrome C from the intermembrane space activates the intrinsic apoptosis pathway. Cytotoxicity measurements of dextran–cytochrome C conjugates thus provide a straightforward metric for cytosolic access of dextran–protein conjugates. We verify that cytochrome C mediates cell death by measuring activation of downstream caspases 3 and 7, indicating that dextran–cytochrome C conjugates promote formation of the apoptosome. These experiments document a new and exciting frontier for polysaccharide bioconjugates and support the existence of an uptake pathway for 1,6‐linked polysaccharides. Support or Funding Information [This work was supported by Grant R01 GM044783 (NIH).] This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Statistical Modeling of the Interference Noise Generated by Computing Platforms (2011)

The trend of electronic systems toward higher integration and higher performance has also brought new challenges to the design of radio transceivers. The decrease of switching times accompanied by the increase of clock speeds, data rates, and interconnection speeds contribute to improve the overall system performance. At the same time, they also affect wireless communications due to an increment of the emissions of electromagnetic radiation. In this paper, we show that the statistics of the baseband components of the noise follow the K-distribution. The one-sided version of this distribution has been derived before as a model for the envelope of sea echo in radar and sonar, however, we show here that its two-sided version can also be used to model the interference noise that affects a transceiver located inside a computer platform. The model shows good agreement with experimental measurements. Also, a closed-form expression of the bit error rate (BER) and some bounds are computed.
Human miRNAs which have eigenvectors of the first component more than 2 in absolute value. (2015)

&lt;p&gt;Human miRNAs which have eigenvectors of the first component more than 2 in absolute value.&lt;/p&gt;
Acute Withdrawal of Nasal CPAP in Obstructive Sleep Apnea Does Not Cause a Rise in Stress Hormones (1996)

We hypothesized that withdrawal of nasal continuous positive airway pressure (CPAP) in patients with sleep apnea would produce a measurable stress response. To test this hypothesis, we ceased CPAP in eight patients regularly using nasal CPAP long term and measured the effect on sleep apnea as well as plasma and urinary levels of the stress hormones, noradrenaline, cortisol and adrenocorticotropic hormone (ACTH). CPAP withdrawal led to an immediate recurrence of sleep apnea with increases in apnea index, arousal index and oxygen desaturation (all p < .0001) but no change in levels of noradrenaline, cortisol or ACTH. We conclude that acute withdrawal of CPAP in patients with sleep apnea does not lead to a classic stress response.
Supplementary figures and tables legends from Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma (2023)

&lt;p&gt;Legends of supplementary figures and tables&lt;/p&gt;
Improving LWD Image and Formation Evaluation by Using Dynamically Corrected Drilling-Derived LWD Depth and Continuous Inclination and Azimuth Measurements (2009)

Summary The paper illustrates the improvements in logging while drilling (LWD) images and subsequent formation evaluation by using a new methodology for depth and survey measurements corrections. LWD depth measurements are often considered inaccurate and, therefore, not as reliable for well-to-well correlations, correlations with data acquired with wireline measurements and formation layer thickness determinations. The reasons for these inaccuracies generally originate from the traditional practice that LWD depth is purposely made equal to the driller's depth, which is a static pipe length measurement made by tape at the surface. There is almost always a difference between the actual measured depth (MD) of the LWD sensor downhole and this static pipe measurement, because downhole the drillpipe is subject to an environment that is not representative of the derrick (e.g., varying drilling mechanical conditions and temperature changes). Here, we demonstrate the applications of the method, which allows dynamic driller's depth correction for the effects of drillstring weight, downhole friction, weight on bit, thermal expansion, residual rig heave, and tide. Another significant inaccuracy source is a standard practice of calculating borehole position from stationary survey points typically taken every 90 feet (ft) using the minimum curvature method. Neglecting the complex borehole shape between survey stations can lead to a systematic error in determining the borehole position. We consider using continuous inclination and azimuth measurements along with stationary surveys to correct these errors. We provide comparisons of LWD images before and after the depth and survey corrections to illustrate how the measurement errors affect formation dips interpreted from the images. We demonstrate how improved accuracy allows filtering out the artifacts and provides more decisive and accurate identification of geologic features. We show how using the corrected 3D position improves accuracy of the formation thicknesses calculations and therefore improves the reservoir summation results. As a result, we propose a borehole 3D position measurement that is accurate, consistent between wells (regardless of rig type or bottomhole assembly [BHA] configuration), and independent of the drilling mode. Using this new measurement significantly improves the quality of the formation evaluation.
Investigation of Thermochemistry Associated with the Carbon–Carbon Coupling Reactions of Furan and Furfural Using ab Initio Methods (2014)

Upgrading furan and small oxygenates obtained from the decomposition of cellulosic materials via formation of carbon-carbon bonds is critical to effective conversion of biomass to liquid transportation fuels. Simulation-driven molecular level understanding of carbon-carbon bond formation is required to design efficient catalysts and processes. Accurate quantum chemical methods are utilized here to predict the reaction energetics for conversion of furan (C4H4O) to C5-C8 ethers and the transformation of furfural (C5H6O2) to C13-C26 alkanes. Furan can be coupled with various C1 to C4 low molecular weight carbohydrates obtained from the pyrolysis via Diels-Alder type reactions in the gas phase to produce C5-C8 cyclic ethers. The computed reaction barriers for these reactions (∼25 kcal/mol) are lower than the cellulose activation or decomposition reactions (∼50 kcal/mol). Cycloaddition of C5-C8 cyclo ethers with furans can also occur in the gas phase, and the computed activation energy is similar to that of the first Diels-Alder reaction. Furfural, obtained from biomass, can be coupled with aldehydes or ketones with α-hydrogen atoms to form longer chain aldol products, and these aldol products can undergo vapor phase hydrocycloaddition (activation barrier of ∼20 kcal/mol) to form the precursors of C26 cyclic hydrocarbons. These thermochemical studies provide the basis for further vapor phase catalytic studies required for upgrading of furans/furfurals to longer chain hydrocarbons.
Supplementary methods from The Magnitude of Androgen Receptor Positivity in Breast Cancer Is Critical for Reliable Prediction of Disease Outcome (2023)

&lt;p&gt;Supplementary Methods&lt;/p&gt;
Protein biomarkers for amyotrophic lateral sclerosis (ALS) in the CSF (2009)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no effective treatments and unclear pathogenic mechanisms. We have explored protein‐based biomarkers in the cerebrospinal fluid (CSF) of ALS patients, healthy controls, and neurologic disease mimics. CSF was collected using standardized protocols from a total of 250 subjects (80 sporadic ALS, 20 familial ALS, 90 healthy controls, 20 multiple sclerosis, 20 Alzheimer's disease, 10 upper motor neuron disease, and 10 lower motor neuron disease). For purposes of this study we generated 25 sample groups, each containing equal amounts of CSF pooled from 10 individuals within a specific subject type. Each sample group was controlled for age, gender, medication, and site of disease onset (for ALS patients). Liquid chromatography mass spectrometry (LC‐MS/MS) was performed on each sample group to identify proteins by mass peptide fingerprinting. We obtained semi‐quantitative data on 4,400 proteins, representing the most complete proteome analysis of the human CSF performed to date. Specific proteins were identified that exhibit alterations in ALS patients. Unsupervised cluster analysis distinguished and separated the sporadic ALS, familial ALS and various control subject groups. We noted proteins that were altered only in specific ALS age groups, suggesting different pathogenic mechanisms in different age populations. Sporadic and familial ALS sample groups were easily distinguished from pure upper or lower motor neuron disease subject groups. We also detected age‐associated changes in proteins within the healthy control population. These findings identified novel protein biomarkers for ALS and highlight biochemical pathways altered during ALS and potential therapeutic targets.
Initiation of hepatitis B virus genome replication and production of infectious virus following delivery in HepG2 cells by novel recombinant baculovirus vector (2008)

One of the major problems in gaining further insight into hepatitis B virus (HBV)/host-cell interactions is to improve the existing cellular models for the study of HBV replication. The first objective of this study was to improve the system based on transduction of HepG2 cells with a recombinant baculovirus to study HBV replication. A new HBV recombinant baculovirus, Bac-HBV-1.1, in which the synthesis of pre-genomic RNA is driven by a strong mammalian promoter, was generated. Transduction with this new recombinant baculovirus led to higher levels of HBV replication in HepG2 cells compared with levels obtained with previously described baculovirus vectors. The initiation of a complete HBV DNA replication cycle in Bac-HBV-1.1-transduced HepG2 cells was shown by the presence of HBV replicative intermediates, including covalently closed circular DNA (cccDNA). Only low levels of cccDNA were detected in the nucleus of infected cells. Data showed that cccDNA resulted from the recycling of newly synthesized nucleocapsids and was bound to acetylated histones in a chromatin-like structure. HBV particles released into the supernatant of transduced HepG2 cells were infectious in differentiated HepaRG cells. Several Bac-HBV-1.1 baculoviruses containing HBV strains carrying mutations conferring resistance to lamivudine and/or adefovir were constructed. Phenotypic analysis of these mutants confirmed the results obtained with the transfection procedures. In conclusion, an improved cell-culture system was established for the transduction of replication-competent HBV genomes. This will be useful for future studies of the fitness of HBV mutants.
IMMU-53. STING-ING GLIOBLASTOMA WITH SPHERICAL NUCLEIC ACIDS (2021)

Abstract The Stimulator of Interferon Genes (STING) pathway represents a major innate immune sensing mechanism for tumor-derived DNA. Modified cyclic dinucleotides (CDNs) that mimic the endogenous STING ligand cGAMP are currently being explored in patients with solid tumors that are amenable to intratumoral delivery. Inadequate bioavailability and insufficient lipophilicity are limiting factors for clinical CDN development, in particular when consideration is given to systemic administration approaches. We have shown that the formulation of oligonucleotides into Spherical Nucleic Acid (SNA) nanostructures, i.e.,the presentation of oligonucleotides at high density on the surface of nanoparticle cores, lead to biochemical and biological properties that are radically different from those of linear oligonucleotides. First-generation brain-penetrant siRNA-based SNAs (NCT03020017, recurrent GBM) have recently completed early clinical trials. Here, we report the development of a STING-agonistic immunotherapy by targeting cGAS, the sensor of cytosolic dsDNA upstream of STING, with SNAs presenting dsDNA at high surface density. The strategy of using SNAs exploits the ability of cGAS to raise STING responses by delivering dsDNA and inducing the catalytic production of endogenous CDNs. SNA nanostructures carrying a 45bp IFN-simulating dsDNA oligonucleotide, the most commonly used and widely characterized cGAS activator, potently activated the cGAS-STING pathway in vitro and in vivo. In a poorly immunogenic and highly aggressive syngeneic mouse glioma model, in which tumours were well-established, only one dose of intranasal treatment with STING-SNAs decelerated tumour growth, improved survival and importantly, was well-tolerated. Our use of SNAs addresses the challenges of nucleic acid delivery to intracranial tumor sites via intranasal route, exploits the binding of dsDNA molecules on the SNA surface to enhance the formation of a dimeric cGAS:DNA complex and establishes cGAS-agonistic SNAs as a novel class of immune-stimulatory modalities for triggering innate immune responses against tumor.
Asymptotic Bounds on the Rate of Locally Repairable Codes (2021)

New asymptotic upper bounds are presented on the rate of sequences of locally repairable codes (LRCs) with a prescribed relative minimum distance and locality over a finite field <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$F$</tex> . The bounds apply to LRCs in which the recovery functions are linear; in particular, the bounds apply to linear LRCs over <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$F$</tex> . The new bounds are shown to improve on previously published results, especially when the repair groups are disjoint.
On-Coupling and Off-Coupling of Neocortical Areas in Chess Experts and Novices (2002)

Abstract This paper presents a pilot study on the differences in evoked EEG coherence measures (computed as zero-lagged cross-correlation, “EC”) between chess experts and novices while solving chess problems. One of our earlier investigations ( Volke, 1999 ) had shown that both location and direction of EC changes in task processing (compared with a resting condition) depend on the degree of task performance. As a result we postulated that when solving the same tasks experts and novices would show different EC. The results of the recent study confirmed this supposition. Chess tasks of varying difficulty were presented to 25 chess players of different performance levels. The EEG was recorded from 29 positions (enhanced 10:20-system). EC were computed for post-stimulus intervals of 1.6s. A special averaging procedure (considering Fisher's Z transformation) was applied for summarizing the single EC of each type of task. These subject- and task-related EC-values (29 × 28/2 = 406 values per frequency band) were subjected to a MANOVA after a two-staged principal component analysis. Significant differences between experts and novices, compared with the resting condition, were found in the delta frequency range. The relevant cortical areas of experts, defined by a topological analysis of the differentiating principal components, were located rather posterior and more in the right hemisphere, compared with those of the novices. Furthermore, the essential EC of the experts showed higher values in the task situation (“on-coupling”), compared with the resting condition, whereas those of the novices were lower (“off-coupling”). The results are interpreted as a higher task-related functional integration of the cortical areas in experts.
RF Design and Development of a Deployable Membrane Reflectarray Antenna for Space (2019)

A new membrane-based deployable reflectarray antenna has been developed for space applications. This lightweight, scalable design can be stowed in very small volumes thereby enabling large, high gain apertures on small satellites. A 4 square meter design has been rigorously tested and characterized (RF and mechanical) on the ground and will be launched on a technology demonstration satellite mission in early 2019. This new reflectarray design has leveraged prior developments of both non-deployable reflect-arrays [1,2] and deployable structures [3]. The paper focuses on the RF design of the reflectarray and briefly addresses future design enhancements that enable greater RF capabilities. The reflectarray mechanical design, related heritage, and some early related RF design/analysis, is also described in [3].
ChemInform Abstract: KOMPLEXCHEMIE REAKTIVER ORGANISCHER VERBINDUNGEN 7. MITT. METALLSTABILISIERTES, C‐PROTONIERTES DIAZOMETHAN, EIN METHANDIAZONIUM‐KOMPLEX (1975)

Abstract Bei Einwirkung von Diazomethan im Überschuß auf Cyclopentadienyltricarbonylwolframhydrid in THF bildet sich bei Temperaturerhöhung von ‐8 5°C auf Raumtemperatur der neutrale Titelkomplex (I), der durch NMR‐, IR‐ und massenspektroskopische Untersuchungen charakterisiert wird.
Stability and fairness of rate estimation-based AIAD congestion control in TCP (2005)

We analyze two achievable rate estimators that use different timestamps of consecutive packets. We examine the effect of the choice of rate estimators on the stability and fairness of a class of TCP protocols that use this estimated rate to implement the additive-increase/adaptive-decrease (AIAD) congestion control. Simulation results confirm our analysis that rate estimation based on the inter-arrival times of the ACK packets is not properly bounded and would cause instability of the AIAD algorithm and unfairness among competing TCP flows, particularly in networks with small or moderate buffer space. Whereas, the rate estimation based on the inter-arrival times of the data packet at the receiver maintains its accuracy even when the reverse path is congested and enables the AIAD algorithm to maintain the stability and fairness as the number of competing flows increases. Our analysis also suggests a straightforward enhancement to TCP Westwood that would improve its stability and fairness. The enhanced algorithm can be easily implemented without any modifications to the TCP receiver-side code by enabling the TCP timestamps option.
A mediated approach to open, large-scale information management (2002)

The explosive expansion of the communications infrastructure, both within and among computing organizations, poses new challenges to the design of distributed information systems. Software systems are required that are open, that can be scaled to extremely large sizes, and that can be constructed and used effectively. The huge amount of information being made available through network technology is still incomprehensible and inconsistent. Previous attempts to address this problem of information management led to local solutions that were not maintainable or scalable, and were limited to retrieving, and not updating, data. We propose a mediator-based approach that supports interoperation of information resources, applications, and interfaces. Unlike previous approaches, mediator-based or otherwise, our solution embodies techniques that specially enable it to exploit modularity, abstraction, and adaptation. This solution enables open, large-scale information management, and emphasizes updates as well as retrievals.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>