gebhart/patrepeval huggingface dataset:
Novel PET/CT imaging biomarkers of CB-839 in combination with panitumumab and irinotecan in patients with metastatic and refractory RAS wildtype (WT) colorectal cancer: A phase I/II study. (2018)

TPS3616 Background: Irinotecan plus panitumumab is active in RAS WT metastatic CRC (mCRC) patients who progress on 5-FU based regimens. Inevitably, patients develop resistance to EGFR inhibition; one such pathway is mediated by the enzyme glutaminase, which converts glutamine to glutamate and is a downstream effector of the EGFR/RAS pathway. Inhibition of this pathway with the selective glutaminase inhibitor CB-839 has stopped growth of cetuximab-sensitive and -resistant HLA-7 CRC cell lines. Greater anti-tumor response with the doublet of cetuximab (or panitumumab) and CB-839 was seen in mouse xenografts of the human CRC line SW48 than with either agent alone. Given this data, we proposed the combination of CB-839 plus panitumumab in RAS WT mCRC patients; to demonstrate on target effect of the therapy, we are utilizing two PET tracers, one which recognizes glutamine and the other glutamate. In addition to safety and efficacy aims, another aim of our study is to correlate SUV changes in pre-treatment and post-cycle 1 carbon-11-labeled glutamine (11C-glutamine) and (4S)-4-(3-[18F]fluoropropyl)-L-glutamate (18F-FSPG) PET with clinical outcome and glutamate levels in plasma. Methods: NCT03263429 is a single arm phase I/II study exploring the combination of CB-839, panitumumab ± irinotecan in RAS WT mCRC patients with at least one prior line of chemotherapy exposure. Phase I has 2 dose levels of CB-839 BID (600 mg and 800 mg) administered with panitumumab 6 mg/kg and irinotecan 180 mg/m2 D1 and D15 each 28-day cycle. Dose escalation is being performed according to a Bayesian continual reassessment method. The Phase II study evaluates CB-839's ability to reverse panitumumab resistance in EGFR inhibitor refractory patients. Irinotecan is included in the phase I for future potential studies in panitumumab-naïve patients. The primary objectives of the phase I and II portions of the study are to demonstrate the maximum tolerated dose and overall response rate of the combination, respectively. A Simon two-stage design is being used in phase II; if ≥ 1 response is seen in the first 10 patients, accrual will continue until 29 patients are enrolled. Clinical trial information: NCT03263429.
Re: Modulation of Apoptotic Response by LAR Family Phosphatases-cIAP1 Signaling during Urinary Tract Morphogenesis (2018)

No AccessJournal of UrologyUrological Survey1 Jun 2018Re: Modulation of Apoptotic Response by LAR Family Phosphatases-cIAP1 Signaling during Urinary Tract Morphogenesis Anthony AtalaMD Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.03.012AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Modulation of Apoptotic Response by LAR Family Phosphatases-cIAP1 Signaling during Urinary Tract Morphogenesis." The Journal of Urology, 199(6), pp. 1399–1400 © 2018 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 199Issue 6June 2018Page: 1399-1400 Advertisement Copyright & Permissions© 2018 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Induction of Protective Immunity against Malaria by Priming-Boosting Immunization with Recombinant Cold-Adapted Influenza and Modified Vaccinia Ankara Viruses Expressing a CD8+-T-Cell Epitope Derived from the Circumsporozoite Protein ofPlasmodium yoelii (2003)

We immunized mice with an attenuated (cold-adapted) influenza virus followed by an attenuated vaccinia virus (modified vaccinia virus Ankara), both expressing a CD8(+)-T-cell epitope derived from malaria sporozoites. This vaccination regimen elicited high levels of protection against malaria. This is the first time that the vaccine efficacy of a recombinant cold-adapted influenza virus vector expressing a foreign antigen has been evaluated.
Sonochemical synthesis of nano-cocrystals (2013)

Cocrystals are multicomponent solids with organic molecules assembled in combination to form a crystalline solid with properties different than the individual components. A cocrystal typically consists of a target molecule crystallized with a second molecule, or cocrystal former, employed to influence properties of the target (e.g. solubility). The conformer interacts with the target via intermolecular forces (e.g. hydrogen bonds) that hold the components together. The modularity of a cocrystal makes such solids attractive for applications where fine-tuning of properties is important (e.g. optical). In this presentation, we describe the use of sonochemistry to form cocrystals of nanoscale dimensions. In contrast to single-component solids, cocrystals present a fundamentally different challenge with respect to those reprecipitation methods used to form nanocrystals since the components of a cocrystal will tend to exhibit different solubilities. We show that sonochemistry affords nano-cocrystals with properties (e.g. reactivity) that contrast solids of macroscale dimensions. Related applications of sonochemistry to afford single-component nanocrystals will also be presented.
Specific Tumor Cell Targeting by a Recombinant MVA Expressing a Functional Single Chain Antibody on the Surface of Intracellular Mature Virus (IMV) Particles (2007)

Recombinant vaccinia virus with tumor cell specificity may provide a versatile tool either for direct lysis of cancer cells or for the targeted transfer of genes encoding immunomodulatory or toxic molecules. We report the expression of a tumor-specific single-chain antibody on the surface of intracellular mature vaccinia virus particles (IMV). The wild-type p14 externally membrane-associated protein p14 (A27L gene), which is not required for viral binding and replication, was replaced by p14 fusion molecules carrying a single-chain antibody directed against the tumor-associated antigen MUC-1. MUC-1 mucin is an epithelial cell antigen whose aberrant expression plays a role in autoimmunity and tumor immunity in the majority of human carcinomas and multiple myeloma. Fusion protein carrying the single-chain antibody at the NH2-terminal position was expressed and exposed at the envelope of the corresponding recombinant virus. The construct containing the antibody was able to bind a MUC-1 specific 60mer peptide. Moreover, targeted virus infects MUC-1-expressing cells in vitro more efficiently.
Metamaterial-inspired absorbers for Terahertz packaging applications (2011)

In this paper, thin metamaterial-inspired structures are investigated for wide-band absorption of stray signals for THz packages. The absorber itself consists of a low-index, low-loss dielectric sandwiched between a patterned, two-dimensionally periodic, thin metallic layer, and a metal backing. Numerical simulations were performed using both the finite element (FEM) and finite-difference time domain (FDTD) numerical methods. Design, fabrication and tests were carried out for absorbers having center frequencies of 0.2 THz and 0.4 THz. Ultra-wide bandwidth and strong absorption were obtained by taking advantage of skin-effect losses in metamaterial structures, and through multi-stacking of these structures. Absorbers having high absorption coefficients and bandwidth (>; 1THz) can easily be fabricated using the approach demonstrated in this paper. Two measurement approaches are applied to characterize these structures, details of which are presented in this paper.
Credit Card Fraud Detection via Machine Learning (2022)

Credit card fraud has recently been a more severe problem since fraudsters are continuously developing more sophisticated fraud techniques. In this work, we have developed a software-based machine learning (ML) system for detecting credit card fraud. Data pre-processing was the first step at which Pearson correlation coefficient was used to decide which features are worth using in our model. Then, k-folds cross validation was used to evaluate the performance of different classifiers: k-Nearest Neighbor (k-NN), Naïve Bayes, Support Vector Machine (SVM), Bagging, Random Forest and Multilayer Perceptron (MLP). To overcome the imbalanced data issue, synthetic minority oversampling technique (SMOTE) was applied to the dataset to generate more fraud data points. To evaluate model's performance, Precision, recall, accuracy and F1 score evaluation metrics were used. With feature correlation of 0.1, SVM had the highest recall score: 88.55%. Also, when implementing SMOTE, the k-NN classifier showed the highest F1 score and precision.
UAV-assisted Efficient Far-field Wireless Charging for WSN (2022)

A wireless sensor network's (WSN's) uptime is highly depended on the lifespans of its wireless sensor nodes (SNs). However, the battery of an SN sometimes may not be easy to be replaced owing to circumstantial constraints. Nowadays, the far-field wireless power transmission (WPT) has attracted more attention from industry and academy. Many researchers have proposed to utilize the WPT technology to remotely charge the SNs. As unmanned aerial vehicle (UAV) can fly close to the SNs located in some hard-to-reach areas, in this work, a UAV is adopted to assist the green base station (GBS) to efficiently power the SNs which are far away from the GBS. Considering the limited energy carried by the UAV and the UAV's energy consumption, we propose a novel UAV comprehensive charging strategy to efficiently power the WSN and to enable all the SNs to be charged with considerable energy replenishment. The simulation results validate our proposed strategy can effectively extend the WSN's uptime.
Diode pumped alkali vapor fiber laser (2023)

A method and apparatus is provided for producing near-diffraction-limited laser light, or amplifying near-diffraction-limited light, in diode pumped alkali vapor photonic-band-gap fiber lasers or amplifiers. Laser light is both substantially generated and propagated in an alkali gas instead of a solid, allowing the nonlinear and damage limitations of conventional solid core fibers to be circumvented. Alkali vapor is introduced into the center hole of a photonic-band-gap fiber, which can then be pumped with light from a pump laser and operated as an oscillator with a seed beam, or can be configured as an amplifier.
Balloon dilatation of benign biliary strictures. (1984)

Percutaneous transhepatic balloon dilatation of benign postoperative biliary strictures was performed in 6 patients. The procedure was curative in 1 patient. These findings indicate the need for repeated long-term, high-pressure dilatation of these strictures, using an inflation device and pressure gauge. Large catheters should be left in place as stents. Early non-surgical management may improve the salvage rate of this surgical complication.
Coating of SWNTs with Nickel by Electroless Plating Method (2005)

This study considers a method for producing SWNTs reinforced lightweight metal-matrix composites. In this research, fluorination has been applied to achieve considerable improvement in the dispersion of purified single-walled carbon nanotubes. It has been demonstrated that surface fluorination is a possible approach to entrap catalytic nucleation centers along the walls of SWNTs. The results show that nickel could be successfully plated onto the activated surfaces of fluorinated SWNTs (F-SWNTs) through electroless plating which is an effective way for producing nanotube/metal systems. It was observed that high surface coverage of Pd-Sn catalytic nuclei is needed to form high quality coatings. A two-step approach was used and the coating mechanism is described in this paper.
The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia (2008)

The G protein-coupled receptor (GPCR) family is highly diversified and involved in many forms of information processing. SREB2 (GPR85) is the most conserved GPCR throughout vertebrate evolution and is expressed abundantly in brain structures exhibiting high levels of plasticity, e.g., the hippocampal dentate gyrus. Here, we show that SREB2 is involved in determining brain size, modulating diverse behaviors, and potentially in vulnerability to schizophrenia. Mild overexpression of SREB2 caused significant brain weight reduction and ventricular enlargement in transgenic (Tg) mice as well as behavioral abnormalities mirroring psychiatric disorders, e.g., decreased social interaction, abnormal sensorimotor gating, and impaired memory. SREB2 KO mice showed a reciprocal phenotype, a significant increase in brain weight accompanying a trend toward enhanced memory without apparent other behavioral abnormalities. In both Tg and KO mice, no gross malformation of brain structures was observed. Because of phenotypic overlap between SREB2 Tg mice and schizophrenia, we sought a possible link between the two. Minor alleles of two SREB2 SNPs, located in intron 2 and in the 3' UTR, were overtransmitted to schizophrenia patients in a family-based sample and showed an allele load association with reduced hippocampal gray matter volume in patients. Our data implicate SREB2 as a potential risk factor for psychiatric disorders and its pathway as a target for psychiatric therapy.
Functional Nonlinear Sparse Models (2020)

Signal processing is rich in inherently continuous and often nonlinear applications, such as spectral estimation, optical imaging, and super-resolution microscopy, in which sparsity plays a key role in obtaining state-of-the-art results. Coping with the infinite dimensionality and non-convexity of these problems typically involves discretization and convex relaxations, e.g., using atomic norms. Nevertheless, grid mismatch and other coherence issues often lead to discretized versions of sparse signals that are not sparse. Even if they are, recovering sparse solutions using convex relaxations requires assumptions that may be hard to meet in practice. What is more, problems involving nonlinear measurements remain non-convex even after relaxing the sparsity objective. We address these issues by directly tackling the continuous, nonlinear problem cast as a sparse functional optimization program. We prove that when these problems are non-atomic, they have no duality gap and can therefore be solved efficiently using duality and (stochastic) convex optimization methods. We illustrate the wide range of applications of this approach by formulating and solving problems from nonlinear spectral estimation and robust classification.
Terahertz Metasurfaces Prototyping Using Low-Cost Hot Stamping (2022)

A rapid and low-cost prototyping technique to fabricate terahertz metallic metasurfaces is presented. Arrays of split-ring resonators, wire-grid polarizers and polarizing beam splitters are demonstrated.
Molecular recognition and catalysis; acceleration of acyl transfer reactions by a hydrogen-bonding receptor (1990)

A hydrogen-bonding receptor containing an appended thiol has been synthesized and shown to cause large rate accelerations (kobs/kuncat > 104) in the thiolysis reaction of complementary barbiturate acetate derivatives.
Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli (2015)

TTP is an anti-inflammatory protein that acts by binding to AREs in its target mRNAs, such as Tnf mRNA, and promoting their deadenylation and decay. TNF released from inflammatory cells can then stimulate gene expression in tissue cells, such as fibroblasts. To determine whether TTP could affect the decay of TNF-induced transcripts in fibroblasts, we exposed primary embryonic fibroblasts and stable fibroblast cell lines, derived from WT and TTP KO mice, to TNF. The decay rates of transcripts encoded by several early-response genes, including Cxcl1, Cxcl2, Ier3, Ptgs2, and Lif, were significantly slowed in TTP-deficient fibroblasts after TNF stimulation. These changes were associated with TTP-dependent increases in CXCL1, CXCL2, and IER3 protein levels. The TTP-susceptible transcripts contained multiple, conserved, closely spaced, potential TTP binding sites in their 3'-UTRs. WT TTP, but not a nonbinding TTP zinc finger mutant, bound to RNA probes that were based on the mRNA sequences of Cxcl1, Cxcl2, Ptgs2, and Lif. TTP-promoted decay of transcripts encoding chemokines and other proinflammatory mediators is thus a critical post-transcriptional regulatory mechanism in the response of secondary cells, such as fibroblasts, to TNF released from primary immune cells.
A Surface-Mountable Suspended Integrated Strip-Line Technology Using Castellated Vias (2023)

Air-suspended packaging techniques have long been desired due to their low-loss, low dispersion, and wideband-capable attributes. However, many, if not all, of the proposed air-suspended technologies over the years have been focused on stand-alone connectorized component design or assume the air cavity will be integrated into a multilayer printed circuit board (PCB) stack-up. However, given the modern-day trend to reduce cost, size, weight, and power, there is a need for air-suspended technologies that can be used in standard PCB assembly processes. In this letter, a novel method of surface mounting the suspended integrated strip-line (SISL) technology is proposed. A castellated via is used as the signal transition from the carrier board to the SISL component to make surface mounting easy and accessible. A wideband thru-line is designed, simulated, fabricated, and measured in the proposed surface-mount technology (SMT) SISL packaging to demonstrate its feasibility. The simulated and measured results agree very well over the 1–6-GHz frequency band validating the design over critical frequency bands. While the proposed method is only shown here for a thru-line, the generalized concept applies to any and all components that can be designed using traditional SISL design procedures.
Real-time motion classification of HD video sequences on embedded systems (2014)

Fast local and global motion estimation (ME) is crucial for a wide variety of different video processing applications, but poses significant requirements on CPU resources. Interestingly, application scenarios shift more and more from traditional PC processing to embedded devices, mostly driven by home automation, machine vision and autonomous navigation. In this paper, we demonstrate how to use DSP capabilities on embedded ARM-based OMAP Systems-On-Chip (SoCs) to provide motion analysis up to HD at speeds of 15-30 fps. We show how to acquire reliable classification of motion types like zoom, rotation or translation, and how to calculate and decompose the so-called homography matrix for further refinement. Our focus lies on navigation sequences from automotive test scenarios, but we also demonstrate the accuracy of the approach on natural video sequences.
Too much electricity through the power lines: a case of left bundle-branch focal tachycardia (2014)

"Too much electricity through the power lines: a case of left bundle-branch focal tachycardia." Acta Cardiologica, 69(4), p. 471
Activating Transcription Factor-2 Mediates Transcriptional Regulation of Gluconeogenic Gene PEPCK by Retinoic Acid (2002)

All-trans-retinoic acid (RA) is known to increase the rate of transcription of the PEPCK gene upon engagement of the RA receptor (RAR). RA also mediates induction of specific gene transcription via several signaling pathways as a nongenomic effect. Here we show that RA upregulation of PEPCK promoter activity requires the cAMP response element (CRE)-1 in addition to the RA-response element and that activating transcription factor-2 (ATF-2) binds the CRE element to mediate this effect. Furthermore, we show that RA treatment potentiates ATF-2-dependent transactivation by inducing specific phosphorylation of ATF-2 by p38beta kinase. ATF-2 activation by RA blocked the inhibitory intramolecular interaction of ATF-2 amino and carboxyl terminal domains in a p38beta kinase-dependent manner. Consistent with these results, RA treatment increased the DNA binding activity of ATF-2 on the PEPCK CRE-1 sequence. Taken together, the data suggest that RA activates the p38beta kinase pathway leading to phosphorylation and activation of ATF-2, thereby enhancing PEPCK gene transcription and glucose production.
Atomic layer deposition of ultrathin and continuous metal films (2014)

The atomic layer deposition (ALD) of ultrathin and continuous metal films is very challenging. This paper describes a general procedure that can yield an ultrathin and continuous metal ALD film using a W ALD adhesion layer.
Design and implementation of tool wear monitoring with radial basis function neural networks (2005)

In this paper, a unified method for constructing dynamic models for tool wear from prior experiments is proposed. The model approximates flank and crater wear propagation and their effects on cutting force using radial basis function neural networks. Instead of assuming a structure for the wear model and identifying its parameters, only an approximate model is obtained in terms of radial basis functions. The appearance of parameters in a linear fashion motivates a recursive least squares training algorithm. This results in a model which is available as a monitoring tool for online application. Using the identified model, a state estimator is designed based on the upper bound covariance matrix. This filter includes the errors in modeling the wear process, and hence reduces filter divergence. Simulations using the neural network for different cutting conditions show good results. Finally, experimental implementation of the wear monitoring system reveals a reasonable ability of the proposed monitoring scheme to track flank wear.
[Establishment and characteristics of a new human choriocarcinoma cell line and its production of tumor markers]. (1987)

A human gestational uterine choriocarcinoma cell line (NJG) was established in vitro. The NJG cell line had been subcultured more than 73 times over 7 years. The cells consisted mainly of Langhans-like cells, while multinucleated cells were occasionally seen. The cells grew in a monolayered sheet, showing a tendency to pile up, with the population doubling in 80 hrs. Electron-microscopically, desmosomes were characteristically observed, which suggested that the cultured cells were of epithelial origin. Chromosomal analysis revealed aneuploidy with a hypertriploid mode and 4 marker chromosomes. Immunocyto- and-histochemical staining for tumor markers of the cultured cells and the transplanted tumors to nude mice showed close similarity. SP1 was occasionally demonstrated and PP5 was faintly stained only in the heterotransplanted tumors, although PP10 and PP12 were not demonstrable. HCG was localized not only in syncytial cells, but also in Langhans cells, and syncytial cells without hCG were also observed in the tumors. A single cell clone was also established from the original NJG cells by a limiting dilution method. The heterotransplanted tumor consisted of Langhans and syncytial cells, indicating that both cells originated from the same cell.
Simvastatin Reduces the Expression of Adhesion Molecules in Circulating Monocytes From Hypercholesterolemic Patients (2003)

Statin-induced inhibition of expression of CD54 and CD18/CD11a in PBMCs and HUVECs with consecutive loss of adhesive function may contribute to the anti-inflammatory effects of these drugs and some of their beneficial clinical activities.
[Scanning electron microscopy studies of morphologic changes in ultra-high molecular weight polyethylene materials after various processing steps]. (1996)

On the basis of these findings, direct compression moulding and a sterilization process in which oxygen is eliminated can be recommended as ways of improving the quality of UHMWPE used for orthopaedic implants.