gebhart/patrepeval huggingface dataset:
Novel microscale memristor with uniqueness property for securing communications (2016)

A rewritable micro-thick low power memristor device is presented. The memristor is fabricated based on a novel structure that is composed of Al/TiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> /Cu. The device switches at 3X lower voltage compared to the existing bipolar memristor state of the art at the microscale. The fabricated device exhibits unique I-V characteristic among similar devices when operated without prior electroforming. Thus, a new secure communication technique is proposed based on the existence of third trust party (TTP). As each host has unique memristor device, messages can be encrypted and decrypted securely using memristor based keys. In addition, Scyther analysis are provided to prove the security of the proposed technique. This work takes advantage of the inherited variation of memristor device electric characteristics to strengthen security algorithm in cryptographic application.
How Water Fosters a Remarkable 5-Fold Increase in Low-Pressure CO2 Uptake within Mesoporous MIL-100(Fe) (2012)

The uptake and adsorption enthalpy of carbon dioxide at 0.2 bar have been studied in three different topical porous MOF samples, HKUST-1, UiO-66(Zr), and MIL-100(Fe), after having been pre-equilibrated under different relative humidities (3, 10, 20, 40%) of water vapor. If in the case of microporous UiO-66, CO(2) uptake remained similar whatever the relative humidity, and correlations were difficult for microporous HKUST-1 due to its relative instability toward water vapor. In the case of MIL-100(Fe), a remarkable 5-fold increase in CO(2) uptake was observed with increasing RH, up to 105 mg g(-1) CO(2) at 40% RH, in parallel with a large decrease in enthalpy measured. Cycling measurements show slight differences for the initial three cycles and complete reversibility with further cycles. These results suggest an enhanced solubility of CO(2) in the water-filled mesopores of MIL-100(Fe).
Successful horizontal completions require an integrated approach (1997)

A variety of organ systems are affected by COVID-19 in the intermediate and longer-term after recovery. Main sequelae include post-infectious fatigue, persistent reduced lung function and carditis. Careful follow-up post COVID 19 is indicated to assess and mitigate possible organ damage and preserve life quality.
Initial lithography results from the digital electrostatic e-beam array lithography concept (2004)

The Digital Electrostatically focused e-beam Array direct-write Lithography (DEAL) concept is currently under development at Oak Ridge National Laboratory (ORNL). This concept incorporates a digitally addressable field-emission array (DAFEA) built into a logic and control integrated circuit to function as the write head for an e-beam lithography tool. The electrostatic focusing is integrated on the DAFEA and consists of additional grids lithographically aligned above the emitters and extraction grid, each separated by a dielectric (nominally low-temperature SiO2) layer. Prototypes of the DAFEA have been fabricated and used to test the focusing of the electron beams and to pattern lines in PMMA resist. First lithography tests have used electron energies of 500 eV to pattern lines less than 1 μm wide at a working distance of 500 μm which extrapolates to &amp;lt;300nm at the nominal DEAL design working distance of 100 μm. Aspects of the DEAL lithography testing and further development are discussed.
A methodology for modeling the effects of systematic within-die interconnect and device variation on circuit performance (2000)

We present a methodology to study the impact of spatial pattern dependent variation on circuit performance and implement the technique in a CAD framework. We investigate the effects of interconnect CMP and poly CD device variation on interconnect delay and clock skew in both aluminum and copper interconnect technology. Our results indicate that interconnect CMP variation strongly affects interconnect delay, while poly CD variation has a large impact on clock skew in a 1 GHz design. Given this circuit impact, CAD tools in the future must account for such systematic within-die variations.
Big-Little Net: An Efficient Multi-Scale Feature Representation for Visual and Speech Recognition (2018)

In this paper, we propose a novel Convolutional Neural Network (CNN) architecture for learning multi-scale feature representations with good tradeoffs between speed and accuracy. This is achieved by using a multi-branch network, which has different computational complexity at different branches. Through frequent merging of features from branches at distinct scales, our model obtains multi-scale features while using less computation. The proposed approach demonstrates improvement of model efficiency and performance on both object recognition and speech recognition tasks,using popular architectures including ResNet and ResNeXt. For object recognition, our approach reduces computation by 33% on object recognition while improving accuracy with 0.9%. Furthermore, our model surpasses state-of-the-art CNN acceleration approaches by a large margin in accuracy and FLOPs reduction. On the task of speech recognition, our proposed multi-scale CNNs save 30% FLOPs with slightly better word error rates, showing good generalization across domains. The codes are available at https://github.com/IBM/BigLittleNet
Detergent decellularization of heart valves for tissue engineering: Toxic effects of residual detergents on human endothelial cells (2006)

Introduction: In tissue engineering detergents were used for cardiac valve decellularization. Detergent remnants, however, are toxic and inhibit a successful cell reseeding. Here we evaluated the efficacy of detergent elimination and susceptibility of treated matrices to recellularization with human endothelial cells (HEC).
Modifications of the metal and support during the deactivation and regeneration of Au/C catalysts for the hydrochlorination of acetylene (2012)

The effect of the gold oxidation state and carbon structure on the activity of Au/C catalysts for the hydrochlorination of acetylene was investigated by a combined approach using TPR, XPS and porosimetry determinations. The activity of the catalyst in the synthesis of vinyl chloride monomer was found to be dependent on the presence of Au3+ species in the catalyst. However, by preparing catalysts with different Au3+ content it was possible to determine the existence of a threshold Au3+ amount, beyond which the excess of Au3+ was not active for the reaction. This was explained by the existence of active sites at the Au/C interface, and not just by the presence of Au3+ species on top of Au nanoparticles, as explained by current models for these catalysts. It was also possible to determine the existence of a subset of Au nanoclusters which do not take part in the reaction, as well as changes in the textural properties of the carbon that can affect its long term reusability.
Distribución cuántica de claves en redes de acceso WDM-PON (2011)

<b>Background:</b> Acute kidney injury (AKI) is a frequent and widely recognized complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Despite relatively high prevalence, AKI after allo-HSCT and its risk factors in children remain obscure. The aim of this study was to describe the prevalence and course of AKI during the first 100 days after allo-HSCT in children and to investigate its associations with baseline characteristics. <b>Methods:</b> Retrospective single-center chart review of all patients under 18 who underwent allo-HSCT during 2011-2017 was performed. AKI was defined using the pediatric RIFLE criteria and only the patients with pRIFLE stage I (eGFR decrease by 50% or more) or higher were considered for the analysis. Recurrent AKI and acute kidney disease (AKD) were defined according to the Acute Disease Quality Initiative consensus. Demographic, clinical, and procedure-related characteristics were recorded at the day of HSCT. <b>Results:</b> Fifty-one patients (68.6% boys) with a median age of 9 years (range: 0.25-17) were included. During a median follow-up of 82 (IQR, 60-98) days, 27 (52.9%) patients experienced a total of 39 AKI episodes, translating into one AKI episode per 100 patient days. Multiple AKIs occurred in 11 (21.6%) patients and 18 (35.3%) progressed to AKD. Four patients died, all with ongoing or previous AKI. Patients with AKD were, on average, older (10 vs. 6 years; <i>p</i> = 0.03) and had higher baseline body mass index (BMI) [standard deviation score (SDS) 0.83 vs. 0.04, <i>p</i> = 0.05], whereas patients with recurrent AKI had higher baseline estimated glomerular filtration rate (eGFR) (244.1 vs. 193.9 ml/min/1.73 m<sup>2</sup>, <i>p</i> = 0.02). In the adjusted Cox models (HR; 95% CI), older age (1.10; 1.01-1.20) was associated with higher risk of overall AKI and higher eGFR (1.02; 1.01-1.04) was associated with higher risk of recurrent AKI, while older age (1.17; 1.04-1.31), higher eGFR (HR 1.01; 1.0-1.02), and higher BMI SDS (1.66; 1.01-2.72) were associated with higher risk of AKD. <b>Conclusions:</b> AKI is a frequent early complication of allo-HSCT in children, and approximately one fifth experience AKI recurrence and one third develop AKD. Older age, higher BMI, and higher eGFR at the day of transplant may have an effect on the risk of AKI development and its course.
Characterization of the Mechanism of Action of a Catalytic Antibody (2007)

The time course of phenylacetate hydrolysis by the catalytic antibody 20G9 has a kinetic burst lasting several reaction cycles. The burst is caused by partial mixed inhibition by one product of the hydrolysis, phenol, which binds with an apparent dissociation constant of 4.6 microM. Phenol binding causes kcat to decrease from 9.1 min-1 to 1.0 min-1 and Km to decrease from 300 microM to 36 microM. Because Km decreases but kcat/Km is unaffected, phenol must perturb the ground state structure but not the transition state structure. Structural complementarity to the transition state seems to be an important contributor to catalysis by 20G9 because weak binding in the ground state can be markedly improved by adding phenol, but tight binding of the transition state, which has been optimized by the immune system, cannot be readily improved. Further evidence that the substrate ground and transition states differ greatly in complementarity to the antibody is that the substrate binds more than five orders of magnitude more weakly than the transition state analogue hapten to which the antibody was raised. Two additional phenol molecules bind at higher product concentrations; the first binds over the concentration range of 15 to 86 microM and accelerates hydrolytic activity by 42%; the second is a competitive inhibitor with a Ki of 140 microM. Binding of multiple phenol molecules suggests the presence of abundant hydrophobic amino acids in the complementarity-determining region of 20G9.
Quick Reaction Force Control for Three-Inertia Resonant System (2019)

This paper proposes a new three-inertia model that considers new transmission factors to achieve quick reaction force control. New transmission factors are confirmed by the analysis results of load-side dynamic characteristics. The load-side dynamic characteristics are measured via input impact torque using a hammer and motor-side velocity response. The experimental results of the input impact torque using a hammer confirm a new anti-resonance frequency with regard to the load-side dynamic characteristics. Therefore, new transmission factors are obtained based on the new anti-resonance frequency. However, the conventional three-inertia model has no new anti-resonance frequency. The consistency of the proposed three-inertia model that considers new transmission factors against plant system is confirmed by using a state observer based on the proposed three-inertia model. Additionally, the effectiveness of the force control system based on the proposed three-inertia model is confirmed by numerical simulations and experiments.
New inhibitors of renin that contain novel phosphostatine Leu-Val replacements (1990)

A novel series of renin inhibitors based on the Phe8-His9-Leu10-Val11 substructure of renin's natural substrate, angiotensinogen, is reported. These inhibitors retain the Phe8-His9 portion of the native substructure and employ novel phosphostatine Leu10-Val11 replacements (LVRs). The phosphostatine LVRs were prepared by condensing a dialkyl phosphonate ester stabilized anion with either N-t-Boc-amino aldehydes or N-tritylamino aldehydes (derived from the corresponding amino acid). Structure-activity relationships at the Leu10 side chain revealed that the LVR derived from L-cyclohexylalanine provided a 130-fold boost in potency over the LVR derived from L-leucine. The dialkyl ester moiety was varied and a loss in potency was incurred when the alkyl ester was chain extended or alpha-branched; dimethyl esters provided optimum potency. The phosphonate moiety was replaced by a half-acid half-ester phosphonate and dimethylphosphinate; both replacements lead to a loss in potency. The more potent inhibitors (IC50 = 20-50 nM) were found to be selective inhibitors for renin over porcine pepsin and bovine cathepsin D (little or no inhibition was observed at 10(-5) M).
Novel Flip-Chip Bonding Technology using Chemical Process (2007)

Reductions of bonding temperature and bonding pressure are regarded as key challenges for higher interconnection-density packages in recent years. To avoid negative factors caused by mechanical process such as thermal stress and mechanical damage of the device circuits, we have developed novel flip-chip bonding technology using electroless NiB plating of the chemical process. Bump connection of 2D pattern using electroless NiB plating was realized by controlling extraneous deposition, which is deposited on insulator layer without catalyst. The potential of the novel flip-chip bonding technology using controlled extraneous deposition of the electroless NiB plating was experimentally demonstrated using 20μm-pitch flip-chip test vehicle.
β2‐Microglobulin Levels in Serum and Urine of Cadmium Exposed Rabbits (1981)

Male rabbits were exposed to cadmium during 16 weeks by subcutaneous injections of either 0.25 mg or 0.5 md Cd as cadmium chloride per kg body weight 3 times per week. beta 2-microglobulin (beta 2-m) and creatinine in serum, cadmium in blood, as well as total protein, creatinine, beta 2-m and cadmium in urine were determined before exposure and after 3 and 7 weeks of exposure. Measurements were also made at 19 weeks, 3 weeks after the last exposure. During exposure, there was a slight increase in the serum beta 2-m/creatinine ratio among rabbits with the highest exposure, while no effect of the cadmium burden could be observed once exposure had ceased. Urinary excretion of beta 2-m was related to urinary pH, which appeared to be the case also for excretion of total protein. In the high exposure group, a significant increase in urinary beta 2-m excretion, indicative of renal tubular dysfunction was seen after 7 weeks of exposure. This was, however, not related to serum beta 2-m levels. It was concluded that before renal damage has occurred even heavy cadmium exposure has very little influence on serum beta 2-m levels.
Comprehensive analysis of the Brassica juncea root proteome in response to cadmium exposure by complementary proteomic approaches (2009)

Indian mustard (Brassica juncea L.) is known to both accumulate and tolerate high levels of heavy metals from polluted soils. To gain a comprehensive understanding of the effect of cadmium (Cd) treatment on B. juncea roots, two quantitative proteomics approaches--fluorescence two-dimensional difference gel electrophoresis (2-D DIGE) and multiplexed isobaric tagging technology (iTRAQ)--were implemented. Several proteins involved in sulfur assimilation, redox homeostasis, and xenobiotic detoxification were found to be up-regulated. Multiple proteins involved in protein synthesis and processing were down-regulated. While the two proteomics approaches identified different sets of proteins, the proteins identified in both datasets are involved in similar biological processes. We show that 2-D DIGE and iTRAQ results are complementary, that the data obtained independently using the two techniques validate one another, and that the quality of iTRAQ results depends on both the number of biological replicates and the number of sample injections. This study determined the involvement of enzymes such as peptide methionine sulfoxide reductase and 2-nitropropane dioxygenase in alternatives redox-regulation mechanisms, as well as O-acetylserine sulfhydrylase, glutathione-S-transferase and glutathione-conjugate membrane transporter, as essential players in the Cd hyperaccumation and tolerance of B. juncea.
Supplementary methods from TTPAL Promotes Colorectal Tumorigenesis by Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling (2023)

&lt;p&gt;Supplementary methods&lt;/p&gt;
Kruppel-like factor4 regulates PRDM1 expression through binding to an autoimmune risk allele (2017)

A SNP identified as rs548234, which is found in <i>PRDM1</i>, the gene that encodes BLIMP1, is a risk allele associated with systemic lupus erythematosus (SLE). BLIMP1 expression was reported to be decreased in women with the <i>PRDM1</i> rs548234 risk allele compared with women with the nonrisk allele in monocyte-derived DCs (MO-DCs). In this study, we demonstrate that BLIMP1 expression is regulated by the binding of Kruppel-like factor 4 (KLF4) to the risk SNP. KLF4 is highly expressed in MO-DCs but undetectable in B cells, consistent with the lack of altered expression of BLIMP1 in B cells from risk SNP carriers. Female rs548234 risk allele carriers, but not nonrisk allele carriers, exhibited decreased levels of BLIMP1 in MO-DCs, showing that the regulatory function of KLF4 is influenced by the risk allele. In addition, KLF4 directly recruits histone deacetylases (HDAC4, HDAC6, and HDAC7), established negative regulators of gene expression. Finally, the knock down of KLF4 expression reversed the inhibitory effects of the risk SNP on promoter activity and BLIMP1 expression. Therefore, the binding of KLF4 and the subsequent recruitment of HDACs represent a mechanism for reduced BLIMP1 expression in MO-DCs bearing the SLE risk allele rs548234.
Fonctionnalisation in situ de réseaux de microplots de silice mésoporeuse réalisés par jet d'encre (2008)

Des réseaux haute définition de microplots de silice mésoporeuse ont été obtenus en combinant le procédé d'impression jet d'encre à l'Auto-Assemblage Induit par Evaporation de tetraethylorthosilicate (TEOS) en présence du copolymère tribloc Pluronic F127 comme tensioactif. Il a été montré que l'ajout de 5% molaires d'un organosilane hydrophobe, le TFTS, F3C(CF2)5CH2CH2Si(OC2H5)3, améliore notablement l'organisation de la mésoporosité en favorisant le co-assemblage du tensioactif et des oligomères de silice. Ainsi le réseau de silice bénéficie de plus de temps avant sa rigidification et permet l'organisation de la porosité en domaines hexagonaux 2D ainsi que le réalignement de ces derniers avec les interfaces. D'autre part, la structuration des microplots a été améliorée (i) en contrôlant le degré initial de condensation du sol avant dépôt : un vieillissement de 48h correspond au temps le plus approprié en considérant à la fois les étapes de co-assemblage et de rigidification du réseau de silice et (ii) en limitant, pendant l'empilement des couches, l'apport de solvant qui peut gêner la structuration contrôlée par l'évaporation et dégrader l'organisation initiale des couches précédentes. En augmentant le temps de séchage entre deux couches successives et en réduisant le volume de la goutte, la structuration des microplots s'en trouve nettement améliorée. Ainsi, des microplots de 25 couches présentent une structure rectangulaire centrée avec des micelles cylindriques parallèles aux interfaces sur 80% de leur volume. Aussi, ce procédé semble particulièrement prometteur et innovant pour la réalisation de capteurs miniaturisés : l'utilisation d'un système d'impression multi-têtes permettrait de générer des réseaux multifonctionnels de microplots mésoporeux différemment fonctionnalisés d'un plot à l'autre. Actuellement, les microplots peuvent être fonctionnalisés par des groupes mercaptopropyl pour la capture de métaux lourds ou semicarbazide pour la ligation de peptides ou encore malonamide pour la complexation d'actinides. Dans tous les cas, la difficulté consiste à greffer in-situ les différentes fonctions en incorporant le précurseur correspondant dans un sol pré-vieilli avant dépôt de microplots par jet d'encre.
Supplementary Data from Artificial Intelligence-Assisted Serial Analysis of Clinical Cancer Genomics Data Identifies Changing Treatment Recommendations and Therapeutic Targets (2023)

Supplementary Data from Artificial Intelligence-Assisted Serial Analysis of Clinical Cancer Genomics Data Identifies Changing Treatment Recommendations and Therapeutic Targets
The oxidative degradation of heterophasic ethylene-propylene copolymers: a comparison of photoproduct formation under natural and accelerated conditions (1997)

The natural weathering behaviour of various heterophasic ethylene–propylene (E–P) copolymers and their fractions was studied. The results are compared with those for polypropylene homopolymer (PP). The extent of natural weathering was monitored by Fourier transform infrared spectroscopy. Also, the photo-oxidation behaviour of isotactic PP, heterophasic E–P copolymers and their fractions under natural exposure were compared with corresponding photoirradiated samples. The photoproducts are produced in the same relative proportions under accelerated and natural exposure, which shows that the mechanisms by which they are formed are not related to the temperature and the photon flux. ©1997 SCI
Molecular Orientations of Delayed Fluorescent Emitters in a Series of Carbazole-based Host Materials (2020)

Molecular orientation is one of the most crucial factors to boost the efficiency of organic light-emitting devices. However, active control of molecular orientation of the emitter molecule by the host molecule is rarely realized so far, and the underlying mechanism is under discussion. Here, we systematically investigated the molecular orientations of thermally activated delayed fluorescence (TADF) emitters in a series of carbazole-based host materials. Enhanced horizontal orientation of the TADF emitters was achieved. The degree of enhancement observed was dependent on the host material used. Consequently, our results indicate that π-π stacking, CH/n (n = O, N) weak hydrogen bonds, and multiple CH/π contacts greatly induce horizontal orientation of the TADF emitters in addition to the molecular shape anisotropy. Finally, we fabricated TADF-based organic light-emitting devices with an external quantum efficiency (ηext) of 26% using an emission layer with horizontal orientation ratio (Θ) of 79%, which is higher than that of an almost randomly oriented emission layer with Θ of 62% (ηext = 22%).