2237 DOES LONG-TERM ASPIRIN USE LOWER SERUM PSA LEVELS? - RESULTS FROM THE DUKE PROSTATE CENTER (2012)

You have accessJournal of UrologyProstate Cancer: Markers II1 Apr 20122237 DOES LONG-TERM ASPIRIN USE LOWER SERUM PSA LEVELS? - RESULTS FROM THE DUKE PROSTATE CENTER Cagri Senocak, Lionel Banez, Jean-Alfred Thomas, Roberto Muller, Leah Gerber, Cary Robertson, Thomas Polascik, Stephen Freedland, Philip Walther, and Judd Moul Cagri SenocakCagri Senocak Durham, NC More articles by this author , Lionel BanezLionel Banez Durham, NC More articles by this author , Jean-Alfred ThomasJean-Alfred Thomas Durham, NC More articles by this author , Roberto MullerRoberto Muller Durham, NC More articles by this author , Leah GerberLeah Gerber Durham, NC More articles by this author , Cary RobertsonCary Robertson Durham, NC More articles by this author , Thomas PolascikThomas Polascik Durham, NC More articles by this author , Stephen FreedlandStephen Freedland Durham, NC More articles by this author , Philip WaltherPhilip Walther Durham, NC More articles by this author , and Judd MoulJudd Moul Durham, NC More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.2413AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Using acetylsalicylic acid - commonly known as aspirin - on a regular basis for cardiovascular protection or inflammatory disease control has been shown to be associated with reduced risk for several cancers, particularly colorectal cancer. Furthermore, current research interests have focused on the association of aspirin use with prostate cancer (CaP) risk and risk for favorable outcomes following treatment. However, few studies have investigated the influence of this ubiquitous pharmacologic agent on prostate-specific antigen (PSA) levels. As such, we examined the influence of aspirin use on serum PSA levels in men with CaP undergoing radical prostatectomy (RP). METHODS We identified 931 men with complete data from the Duke Prostate Center database who underwent RP from 2005 to 2009 and had known maintenance aspirin use status prior to surgery. We used Mann-Whitney test to assess the univariate association between aspirin use and pre-operative PSA. Linear regression models were used to determine associations of aspirin use with PSA independent of age, race, first-degree family history of CaP, year of surgery, body mass index, post-operative Gleason sum, surgical margins, extra-capsular extension, seminal vesicle invasion, lymph node invasion, and prostate specimen weight. RESULTS A total of 325 men (35%) were prescribed aspirin prior to RP. Aspirin users tended to be older (p<0.001) and Caucasian (p=0.007) compared to non-users. The median unadjusted PSA level for aspirin users and non-aspirin users were 5.0 and 5.3 ng/ml (p=0.03), respectively. After controlling for various clinical and pathological confounders, aspirin use was significantly associated with lower PSA levels (p=0.03). Mean-adjusted PSA levels (95% CI) for aspirin users and non-aspirin users were 4.95 (4.65-5.27) and 5.41 (5.17-5.66) ng/ml, respectively. CONCLUSIONS In a cohort of men with CaP, all undergoing RP, aspirin use was associated with an 8.5% reduction in preoperative serum PSA levels. These results need verification in other RP cohorts and in men without CaP. In addition, whether lower PSA levels related to aspirin use suggests that this anti-inflammatory drug alters prostate biology or CaP growth and development requires further investigation. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e902 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Cagri Senocak Durham, NC More articles by this author Lionel Banez Durham, NC More articles by this author Jean-Alfred Thomas Durham, NC More articles by this author Roberto Muller Durham, NC More articles by this author Leah Gerber Durham, NC More articles by this author Cary Robertson Durham, NC More articles by this author Thomas Polascik Durham, NC More articles by this author Stephen Freedland Durham, NC More articles by this author Philip Walther Durham, NC More articles by this author Judd Moul Durham, NC More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...