gebhart/patrepeval huggingface dataset:
Carbon-13-proton cross-polarization in liquids (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-13-proton cross-polarization in liquidsR. D. Bertrand, W. B. Moniz, A. N. Garroway, and G. C. ChingasCite this: J. Am. Chem. Soc. 1978, 100, 16, 5227–5229Publication Date (Print):August 1, 1978Publication History Published online1 May 2002Published inissue 1 August 1978https://pubs.acs.org/doi/10.1021/ja00484a063https://doi.org/10.1021/ja00484a063research-articleACS PublicationsRequest reuse permissionsArticle Views250Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optical microscopy of targeted drug delivery and local distribution in skin of a topical minocycline: implications in translational research and guidance for therapeutic dose selection (Conference Presentation) (2017)

Acne vulgaris is a chronic inflammatory skin condition commonly resulting in negative aesthetic and social impacts on those affected. Minocycline, currently available as an oral antibiotic for moderate to severe acne, has a known minimum inhibitory concentration (MIC) for the acne-causing bacterium Propionibacterium acnes (P. acnes) in vitro, with its anti-inflammatory properties also eliciting inhibitory effects on pro-inflammatory molecules. A novel topical gel composition containing solubilized minocycline (BPX-01) has been developed to directly deliver the drug to the skin. Because minocycline is a known fluorophore, fluorescence microscopy and concurrent quantitative measurements were performed on excised human facial skin dosed with different concentrations, in order to determine the spatial distribution of the drug and quantification of its local concentration in the epidermis and the pilosebaceous unit where P. acnes generally reside. Local minocycline delivery confirmed achievement of an adequate therapeutic dose to support clinical studies. Subsequently, a 4-week double-blind, randomized, vehicle controlled clinical study was performed to assess the safety and efficacy of 1% minocycline BPX-01 applied daily. No instances of cutaneous toxicity were reported, and a greater than 1 log reduction of P. acnes count was observed at week 4 with statistical significance from baseline and vehicle control. In addition, no detectable amounts of minocycline in the plasma were reported, suggesting the potential of this new formulation to diminish the known systemic adverse effects associated with oral minocycline. Follow-on clinical plans are underway to further establish the safety of BPX-01 and to evaluate its efficacy against inflammatory acne lesions in a 225 patient multi-center dose-finding study.
Interstitial lung disease reveals 48,XXYY syndrome in a child (2019)

The authors have no conflicts of interest to declare. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
High-Speed Railway Communication System Using Linear-Cell-Based Radio-Over-Fiber Network and Its Field Trial in 90-GHz Bands (2019)

A linear-cell-based radio-over-fiber (LC-RoF) system is proposed and demonstrated for efficient mobile communication in high-speed trains without hard handover processes. The configuration of the LC-RoF network and possible router architectures are discussed for the field trial test of the proposed system and for advanced systems in the future. Via the LC-RoF network, 90-GHz, millimeter-wave radio access between the ground and a train car is operated in a centralized manner. The resulting throughput of 1.5 Gbit/s is achieved in the field trial test, which is comprised of 250-Mbaud four-subcarrier differential quadrature phase-shift keying with a forward-error correction code implemented in field-programmable gate arrays to the Shinkansen train traveling at 240 km/h without any interruptions in the connections at the change of radio access units.
Extreme Phase-Amplification under Direct Detection of Atomic States for Heisenberg Limited Sensitivity in an Atomic Interferometer Employing Schroedinger Cat States (2017)

We show that for an N-particle atom interferometer, an N-fold reduction in fringe-width due to phase amplification can be achieved via direct detection of atomic states, employing Schroedinger Cat states, yielding Heisenberg limited sensitivity.
A Systematic Approach to Investigate the Tolerance of 53.5 GBaud 33%-RZ-DQPSK towards Optical Filtering and Residual Chromatic Dispersion based on Experiments (2011)

We experimentally investigate 107 Gb/s 33%-RZ-DQPSK to explore its tolerance towards chromatic dispersion and narrow-band optical filtering. The results indicate that dispersion tolerance can be increased by the use of appropriate filters.
Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel (2012)

Despite major improvements in outcome over the past decades, acute myeloid leukemia (AML) remains a life-threatening malignancy in children, with current survival rates of ∼70%. State-of-the-art recommendations in adult AML have recently been published in this journal by Döhner et al. The primary goal of an international expert panel of the International BFM Study Group AML Committee was to set standards for the management, diagnosis, response assessment, and treatment in childhood AML. This paper aims to discuss differences between childhood and adult AML, and to highlight recommendations that are specific to children. The particular relevance of new diagnostic and prognostic molecular markers in pediatric AML is presented. The general management of pediatric AML, the management of specific pediatric AML cohorts (such as infants) or subtypes of the disease occurring in children (such as Down syndrome related AML), as well as new therapeutic approaches, and the role of supportive care are discussed.
Haploinsufficiency of two histone modifier genes on 6p22.3, ATXN1 and JARID2, is associated with intellectual disability (2013)

Patients carrying JARID2 deletion manifested with cognitive impairment, gait disturbance and a characteristic facial appearance, whereas patients with deletion of ATXN1 seemed to be characterized by intellectual disability and behavioural abnormalities. Due to the characteristic facial appearance, JARID2 haploinsufficiency might represent a clinically recognizable neurodevelopmental syndrome.
Orthogonal quincunx wavelets with fractional orders (2002)

We present a new family of 2D orthogonal wavelets which use quincunx sampling. The orthogonal refinement filters have a simple analytical expression in the Fourier domain as a function of the order /spl alpha/, which may be non-integer. The wavelets have good isotropy properties. We can also prove that they yield wavelet bases of L/sub 2/(R/sup 2/) for any /spl alpha/>0. The wavelets are fractional in the sense that the approximation error at a given scale /spl alpha/ decays like O(a/sup /spl alpha//); they also essentially behave like fractional derivative operators. To make our construction practical, we propose an FFT-based implementation that turns out to be surprisingly fast. In fact, our method is almost as efficient as the standard Mallat algorithm for separable wavelets.
Vectorisation de pièges à radicaux libres en vue d'un ciblage cellulaire (1999)

Le but de ce travail a ete d'ameliorer la biodistribution des agents de piegeage de type nitrone. Nous avons synthetise la lampbn et la lamppn, derives des nitrones pbn et ppn comportant un groupement lactobionamide permettant d'envisager le ciblage d'un type de cellules donnees par le biais des lectines membranaires. Nous avons egalement prepare la ta1pbn constituee par un motif derive de la pbn et un vecteur amphiphile glycosyle derive du tris susceptible de favoriser le transport in vivo et le passage trans-membranaire. Des etudes physico-chimiques ont montre que la ta1pbn s'organise dans l'eau sous forme de vesicules. L'etude par rpe des capacites de piegeage in vitro de la lampbn et de la lamppn a demontre que l'introduction de groupements glycosyles est compatible avec le piegeage de radicaux libres par la fonction nitrone. L'etude par rpe du piegeage in vitro des radicaux oxygenes et carbones sur la ta1pbn a montre que, du fait de son organisation en solution, les capacites de piegeage de la molecule dependent de la reactivite du radical et de son caractere polaire et ionique. Par ailleurs, les resultats des tests biologiques ont confirme le potentiel de ciblage de ces trois molecules.
Lp_3485, an α-D-galactosidase from Lactobacillus plantarum WCFs1: production and biochemical characterization (2017)

Póster presentado a la VII International Conference on Environmental Industrial and Applied Microbiology, celebrada en Madrid (España) del 18 al 20 de octubre de 2017.
Can index lesion tumor volume on T2 weighted MRI predict biochemical recurrence following radical prostatectomy? (2017)

32 Background: Several studies have demonstrated an association in prostate cancer patients between the tumor volume of the index lesion calculated from whole mount pathology after radical prostatectomy and biochemical recurrence (BCR). We aimed to evaluate whether the index lesion tumor volume (ILTV) measured on MRI would have similar predictive ability. Methods: Clinical and pathologic data from a prospectively maintained, single-institution database was analyzed for 501 patients who underwent RARP (without prior therapy) between 2007 and 2016. Patients were excluded if they were found to have metastatic disease on pathology or if postoperative PSA ≥ 0.2ng/ml after RARP. ILTV was calculated from T2W MRI by multiplying length by width by depth by 0.52. Tumor volume was stratified into two categories based on the cutoff of 2cm 3 . BCR was defined as 2 PSA values ≥ 0.2 ng/ml, 1 PSA value ≥ 0.4 ng/ml, or receipt of radiation therapy/hormonal therapy after RARP. Cox proportional hazard regression was used to assess associations of clinical, imaging, and histopathological variables with BCR. Results: The median age of our cohort was 60 years (IQR 10) and median PSA was 6.20 ng/ml (IQR 6). Of the 493 patients who met our inclusion criteria, 55 (11.2%) experienced BCR. Patients with ILTV &gt; 2cc had a higher incidence of BCR compared to those with ILTV &lt; 2cc (18.0% vs 8.8%, p = 0.008). On univariate analysis, age (HR 0.96, p = 0.026), PSA (HR 1.04, p &lt; 0.001), black race (HR 1.816, p = 0.047), Gleason 8-10 on biopsy (HR 3.725, p &lt; 0.001), and ILTV (HR 2.496, p = 0.002) were significant for prediction of BCR. Although age (HR 0.955, p = 0.021), PSA (HR 1.029, p = 0.013), and Gleason 8-10 on biopsy (HR3.367, p &lt; 0.001) were found to be independent predictors of BCR, tumor volume was not found to be an independent predictor (HR 0.960, p = 0.642). Conclusions: Although ILTV alone was predictive of BCR, ILTV was not found to be an independent predictor of BCR, indicating that at this time, MRI cannot yet measure ILTV with enough accuracy to predict oncologic outcomes. As imaging technology improves, ILVT may provide additional prognostic information.
Optical communication and navigation for spacecraft docking using modulating retroreflectors (2005)

An optical communications link is used to transmit important navigation and range information between two spacecraft platforms to aid in the spacecraft docking process. This experiment uses NRL's multiple quantum well modulating retroreflector (MRR) array as the light payload optical communications transmitter on the target spacecraft. Spacecraft navigation information is determined by using the MRR array to impose five distinct modulation frequencies on the optical transmit beam, and analyzing the received signal on the pursuer spacecraft to extract target attitude and range information. Design, architecture, and status of the experiment at NRL are discussed.
Alternating Gradient Descent and Mixture-of-Experts for Integrated Multimodal Perception (2023)

We present Integrated Multimodal Perception (IMP), a simple and scalable multimodal multi-task training and modeling approach. IMP integrates multimodal inputs including image, video, text, and audio into a single Transformer encoder with minimal modality-specific components. IMP makes use of a novel design that combines Alternating Gradient Descent (AGD) and Mixture-of-Experts (MoE) for efficient model and task scaling. We conduct extensive empirical studies and reveal the following key insights: 1) Performing gradient descent updates by alternating on diverse modalities, loss functions, and tasks, with varying input resolutions, efficiently improves the model. 2) Sparsification with MoE on a single modality-agnostic encoder substantially improves the performance, outperforming dense models that use modality-specific encoders or additional fusion layers and greatly mitigates the conflicts between modalities. IMP achieves competitive performance on a wide range of downstream tasks including video classification, image classification, image-text, and video-text retrieval. Most notably, we train a sparse IMP-MoE-L variant focusing on video tasks that achieves new state-of-the-art in zero-shot video classification: 77.0% on Kinetics-400, 76.8% on Kinetics-600, and 68.3% on Kinetics-700, improving the previous state-of-the-art by +5%, +6.7%, and +5.8%, respectively, while using only 15% of their total training computational cost.
Design Method of Variable-Latency Circuit with Tunable Approximate Completion-Detection Mechanism (2020)

Advanced information-processing services such as computer vision require a high-performance digital circuit to perform high-load processing at high speed. To achieve high-speed processing, several image-processing applications use an approximate computing technique to reduce idle time of the circuit. However, it is difficult to design the high-speed image-processing circuit while controlling the error rate so as not to degrade service quality, and this technique is used for only a few applications. In this paper, we propose a method that achieves high-speed processing effectively in which processing time for each task is changed by roughly detecting its completion. Using this method, a high-speed processing circuit with a low error rate can be designed. The error rate is controllable, and a circuit design method to minimize the error rate is also presented in this paper. To confirm the effectiveness of our proposal, a ripple-carry adder (RCA), 2-dimensional discrete cosine transform (2D-DCT) circuit, and histogram of oriented gradients (HOG) feature calculation circuit are evaluated. Effective clock periods of these circuits obtained by our method with around 1% error rate are improved about 64%, 6%, and 12%, respectively, compared with circuits without error. Furthermore, the impact of the miscalculation on a video monitoring service using an object detection application is investigated. As a result, more than 99% of detection points required to be obtained are detected, and it is confirmed the miscalculation hardly degrades the service quality.
Glucuronoxylomannan, a Microbial Compound, Regulates Expression of Costimulatory Molecules and Production of Cytokines in Macrophages (2004)

Glucuronoxylomannan (GXM) is a microbial compound that can modulate the immune response. We investigated (1) the receptors involved in uptake of GXM on monocyte-derived macrophages (MDMs) from healthy donors, (2) the effects of GXM on expression of specific receptors, (3) the effects of GXM mediated by pattern-recognition receptors, and (4) GXM modulation of MDM accessory and secretory functions. Cellular receptors involved in uptake of GXM included Fc gamma RII, CD18, Toll-like receptor (TLR) 4, and CD14. Some biological functions of MDMs were profoundly affected by treatment with GXM, resulting in (1) increased expression of CD40 and CD86 via perturbation of TLR4, (2) decreased expression of major histocompatibility complex class II, (3) induction of interleukin-10 but not of tumor necrosis factor-alpha, and (4) decreased lipopolysaccharide (LPS)-induced production of cytokines. GXM represents an attractive compound to limit inflammatory processes and induce an LPS-tolerant state.
Distributed 8×6 MIMO Experiments for Optical Wireless Communications (2017)

We experimentally investigate antenna diversity schemes for robust optical wireless communications with large coverage in industrial manufacturing environments. Our proposed scheme improves the average and peak data rates by up to 28 % and 75 %, respectively.
Targeted discovery proteomics to identify clinical phenotypes in heart failure with preserved ejection fraction: a proteomics substudy of VITALITY-HFpEF (2022)

Abstract Background Heart failure with preserved ejection fraction (HFpEF) is a heterogenous syndrome that may emerge from overlapping systemic processes associated with several medical co-morbidities, often within an inflammatory milieu. Identification of unique proteins associated with distinct phenotypes may yield insight into novel therapeutics. Purpose Determine if unique clusters of circulating proteins are associated with specific clinical characteristics in patients with HFpEF. Methods A targeted discovery proteomics approach with 358 unique proteins associated with cardiovascular disease and inflammation (Olink) was used at baseline in VITALITY-HFpEF among 789 participants with documented left ventricular EF ≥45% and recent decompensation (&amp;lt;6 mos). Proteins were clustered applying the weighted correlation network analysis (WCNA). The associations of the clinical characteristics and frailty and clusters were estimated with linear regression adjusted for age and eGFR. Frailty was characterized as normal, pre-frail, and frail using the Fried criteria. KCCQ was the primary and 6-minute walk distance (6MWD) the secondary endpoint of VITALITY-HFpEF. Results Four unique clusters were identified containing 24, 66, 197, and 81 proteins, respectively. Figure 1 shows the adjusted association of the 4 protein clusters, shown with their hub proteins, with the clinical characteristics. The color (red: positive, green: negative relationship) and intensity indicate the magnitude of the standardized difference (relative to the variation [i.e., T-value]); p-value shown in boxes. Cluster 3, with tumor necrosis factor receptor 1 as a hub protein that mediates apoptosis and inflammation, was associated with greater frailty and physical limitation along with shorter 6MWD. In contrast, cluster 4, with protein C as a hub protein that regulates anticoagulation and exerts a protective function on endothelial cells, is associated with less frailty and younger age, and more frequently male sex. Cluster 2 was associated with only younger age and cluster 1 with no clinical characteristics. Conclusions Proteomics appear to identify specific clinical phenotypes associated with HFpEF. Further exploration of this approach may provide insight into the diverse pathophysiology characterizing this disorder and a more targeted approach to therapy. Funding Acknowledgement Type of funding sources: Private company. Main funding source(s): VITALITY-HFpEF was funded by Merck Sharp &amp; Dohme Corp., a subsidiary of Merck &amp; Co., Inc., Kenilworth, NJ, USA and Bayer AG, Wuppertal, Germany.
A model and an evolutionary algorithmic approach towards optimization of Electric Vehicle fleet charging (2015)

The prevalence of the Smart Grid and its capabilities, has enabled sophisticated energy management that can be realized as a multi-constraint optimization problem and tailored to the specific scenario needs. In conjunction with the increasing introduction of Electric Vehicles (EVs), energy management tools can now consider expanded conditions including grid balance, cost optimization, EV characteristics, asset utilization, operational goals etc. In this work we analyze such a scenario and demonstrate how an EV fleet charging can be optimized in a timely manner while taking into consideration local conditions e.g., individual EV needs as well as global ones e.g., grid limits and energy price. We formalize a model that reflects the EV restrictions, and use it to assess an algorithmic approach that solves this non-linear optimization problem.
Resistance to receptor-blocking therapies primes tumors as targets for HER3-homing nanobiologics (2017)

Resistance to anti-tumor therapeutics is an important clinical problem. Tumor-targeted therapies currently used in the clinic are derived from antibodies or small molecules that mitigate growth factor activity. These have improved therapeutic efficacy and safety compared to traditional treatment modalities but resistance arises in the majority of clinical cases. Targeting such resistance could improve tumor abatement and patient survival. A growing number of such tumors are characterized by prominent expression of the human epidermal growth factor receptor 3 (HER3) on the cell surface. This study presents a "Trojan-Horse" approach to combating these tumors by using a receptor-targeted biocarrier that exploits the HER3 cell surface protein as a portal to sneak therapeutics into tumor cells by mimicking an essential ligand. The biocarrier used here combines several functions within a single fusion protein for mediating targeted cell penetration and non-covalent self-assembly with therapeutic cargo, forming HER3-homing nanobiologics. Importantly, we demonstrate here that these nanobiologics are therapeutically effective in several scenarios of resistance to clinically approved targeted inhibitors of the human EGF receptor family. We also show that such inhibitors heighten efficacy of our nanobiologics on naïve tumors by augmenting HER3 expression. This approach takes advantage of a current clinical problem (i.e. resistance to growth factor inhibition) and uses it to make tumors more susceptible to HER3 nanobiologic treatment. Moreover, we demonstrate a novel approach in addressing drug resistance by taking inhibitors against which resistance arises and re-introducing these as adjuvants, sensitizing tumors to the HER3 nanobiologics described here.