gebhart/patrepeval huggingface dataset:
Carrier-Based Modulated Model Predictive Control Strategy for Three-Phase Two-Level VSIs (2021)

The implementation of finite-control-set model predictive control (FCS-MPC) in voltage source inverters (VSIs) can make the system suffer from poor current harmonics performance, which may complicate the design of the required AC filter. To overcome this shortcoming, a carrier-based modulated model predictive control (CB-MMPC) strategy is proposed in this paper. This method enables the utilization of existing PWM modulation techniques with FCS-MPC, where a modulation waveform with zero-sequence signal injection is generated and compared to a triangular carrier wave, while optimizing the selection of the switching states. As it is shown, the studied CB-MMPC strategy not only considerably improves the current total harmonic distortion (THD) but also attains the performance of fast current dynamic response and robustness as the traditional FCS-MPC. Herein, the detailed implementation of the CB-MMPC control strategy is given, while considering its application to the current feedback control loop of a three-phase three-wire two-level VSI modulated at constant switching frequency. Finally, PLECS circuit simulation and a 3-kW VSI prototype are used to verify the superiority and the effectiveness of the presented CB-MMPC strategy. This is also benchmarked to the FCS-MPC and dead-beat based controllers.
Optimization of MSB for future technology nodes (2012)

In the ITRS roadmap [1] increasingly long mask write and cycle time is explicitly addressed as a difficult challenge in mask fabrication for the 16nm technology node and beyond. Write time reduction demands have to be seen in relation to corresponding performance parameters like Line Width Roughness (LWR), resolution, placement as well as CD Uniformity. The previously presented Multi Shaped Beam (MSB) approach [2, 3] is considered a potential solution for high throughput mask write application. In order to fully adapt the MSB concept to future industry's requirements specific optimizations are planned. The key element for achieving write time reduction is a higher probe current at the target, which can be obtained by increasing the number of beamlets as well as applying a higher current density. In the present paper the approach of a 256 beamlet MSB design will be discussed. For a given image field size along with a beamlet number increase both beamlet pitch and size have to be optimized. Out of previous investigations, one finding was that by changing the demagnification after the beam forming section of the MSB column the overall performance can be optimized. Based on first electron-optical simulations for a new final lens a larger demagnification turned out to be advantageous. Stochastic beam blur simulation results for the MSB reduction optics will be presented. During the exposure of a pattern layout the number of used beams, their shape and their distribution within the image field varies, which can lead to space charge distortion effects. In regard to this MSB simulation results obtained for an image field of approximately 10x10ìm² will be presented. For the 256 beamlet MSB design and resist sensitivities of 20&mu;C/cm<sup>2</sup>, 40&mu;C/cm<sup>2</sup> and 100&mu;C/cm<sup>2</sup> write time and LWR simulations have been performed. For MSB pattern data fracturing an optimized algorithm has been used, which increased the beamlet utilization factor (indicates the mean number of beamlets which are used per multi-shot). Finally an update with regard to the required changes of the data path architecture for the 256 beamlet MSB approach will be given. Data integrity as an important aspect of the production worthiness of such a systems will be discussed specifically.
Particulate emissions from commercial shipping (2009)

We characterize particulate emissions on the basis of chemical, physical, and optical properties from commercial vessels. Observations during the Texas Air Quality Study/Gulf of Mexico Atmospheric Composition and Climate Study 2006 field campaign provide chemical and physical characteristics including sulfate (SO₄²⁻) mass, organic matter (OM) mass, black carbon (BC) mass, particulate matter (PM) mass, number concentrations (condensation nuclei (CN) &gt; 5 nm), and cloud condensation nuclei (CCN). Optical characterization included multiple wavelength visible light absorption and extinction, extinction relative humidity dependence, and single scatter albedo (SSA). The global contribution of shipping PM was calculated to be 0.90 Tg a⁻¹, in good agreement with previous inventories (0.91 and 1.13 Tg a⁻¹ from Eyring et al. (2005a) and Wang et al. [2008]). Observed PM composition was 46% SO₄²⁻, 39% OM, and 15% BC and differs from inventories that used 81%, 14%, and 5% and 31%, 63%, and 6% SO₄²⁻, OM, and BC, respectively. SO₄²⁻ and OM mass were found to be dependent on fuel sulfur content as were SSA, hygroscopicity, and CCN concentrations. BC mass was dependent on engine type and combustion efficiency. A plume evolution study conducted on one vessel showed conservation of particle light absorption, decrease in CN &gt; 5 nm, increase in particle hygroscopicity, and an increase in average particle size with distance from emission. These results suggest emission of small nucleation mode particles that subsequently coagulate/condense onto larger BC and OM. This work contributes to an improved understanding of the impacts of ship emissions on climate and air quality and will also assist in determining potential effects of altering fuel standards.
Postnatal Expansion, Maturation and Functionality of MR1T Cells in Humans (2019)

Abstract MR1-restricted T (MR1T) cells are defined by their recognition of metabolite antigens presented by the monomorphic MHC class 1-related molecule, MR1, the most highly conserved MHC class I related molecule in mammalian species. Mucosal-associated invariant T (MAIT) cells are the predominant subset of MR1T cells expressing an invariant TCR α-chain, TRAV1-2. These cells comprise a T cell subset that recognizes and mediates host immune responses to a broad array of microbial pathogens, including Mycobacterium tuberculosis . Here, we sought to characterize development of circulating human MR1T cells as defined by MR1-5-OP-RU tetramer labelling and of the TRAV1-2 + MAIT cells defined by expression of TRAV1-2 and high expression of CD26 and CD161 (TRAV1-2 + CD161 ++ CD26 ++ cells). We analysed postnatal expansion, maturation and functionality of peripheral blood MR1-5-OP-RU tetramer + MR1T cells in cohorts from three different geographic settings with different tuberculosis (TB) vaccination practices, levels of exposure to and infection with M. tuberculosis. Early after birth, frequencies of MR1-5-OP-RU tetramer + MR1T cells increased rapidly by several fold. This coincided with the transition from a predominantly CD4 + and TRAV1-2 − population in neonates, to a predominantly TRAV1-2 + CD161 ++ CD26 ++ CD8 + population. We also observed that tetramer + MR1T cells that expressed TNF upon mycobacterial stimulation were very low in neonates, but increased ∼10-fold in the first year of life. These functional MR1T cells in all age groups were MR1-5-OP-RU tetramer + TRAV1-2 + and highly expressed CD161 and CD26, markers that appeared to signal phenotypic and functional maturation of this cell subset. This age-associated maturation was also marked by the loss of naïve T cell markers on tetramer + TRAV1-2 + MR1T cells more rapidly than tetramer + TRAV1-2 − MR1T cells and non-MR1T cells. These data suggest that neonates have infrequent populations of MR1T cells with diverse phenotypic attributes; and that exposure to the environment rapidly and preferentially expands the MR1-5-OP-RU tetramer + TRAV1-2 + population of MR1T cells, which becomes the predominant population of functional MR1T cells early during childhood.
Half-micron gate GaAs MESFET technology using selectively-grown N/sup +/ layer for high speed static RAM fabrication (2003)

Processing technology for a high-performance 0.5- mu m gate GaAs MESFET using a selectively grown n/sup +/ layer is described. In order to realize the high-performance MESFET with a 0.5- mu m gate, a selectively grown n/sup +/ layer and a shallow MESFET channel were used. The low-resistivity n/sup +/ layer markedly decreases the series resistance of the MESFET and realizes a high K value of more than 500 mS/Vmm. However, in order to utilize the process in LSI fabrication, the problem of the dependence of growth rate on the pattern density must be overcome. In this study, dummy pattern is added to the low-density region to get uniform growth rate of the SRAM (static RAM) chip. The technology has been used to realize a 4-kb SRAM with subnanosecond access time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Dynamic group testing to control and monitor disease progression in a population (2021)

In the context of a pandemic like COVID-19, and until most people are vaccinated, proactive testing and interventions have been proved to be the only means to contain the disease spread. Recent academic work has offered significant evidence in this regard, but a critical question is still open: Can we accurately identify all new infections that happen every day, without this being forbiddingly expensive, i.e., using only a fraction of the tests needed to test everyone everyday (complete testing)? Group testing offers a powerful toolset for minimizing the number of tests, but it does not account for the time dynamics behind the infections. Moreover, it typically assumes that people are infected independently, while infections are governed by community spread. Epidemiology, on the other hand, does explore time dynamics and community correlations through the well-established continuous-time SIR stochastic network model, but the standard model does not incorporate discrete-time testing and interventions. In this paper, we introduce a "discrete-time SIR stochastic block model" that also allows for group testing and interventions on a daily basis. Our model can be regarded as a discrete version of the continuous-time SIR stochastic network model over a specific type of weighted graph that captures the underlying community structure. We analyze that model w.r.t. the minimum number of group tests needed everyday to identify all infections with vanishing error probability. We find that one can leverage the knowledge of the community and the model to inform nonadaptive group testing algorithms that are order-optimal, and therefore achieve the same performance as complete testing using a much smaller number of tests.
Effects of high inclusion of soybean hulls on apparent total tract macronutrient digestibility, fecal quality, and fecal fermentative end-product concentrations in extruded diets of adult dogs (2019)

Soybean hulls (SBH) are a fiber-rich co-product of the soybean oil extraction process that corresponds to 8% of the soybean seed. Despite being readily available and priced competitively, SBH are underutilized in monogastric nutrition. Thus, the objective of this study was to evaluate SBH as a dietary fiber in canine diets. Four diets were formulated with either SBH, beet pulp (BP), or cellulose (CL) as the main source of dietary fiber (15% total dietary fiber [TDF]), with the control diet formulated with no supplemental fiber (NF). Animal procedures were approved by the University of Illinois Institutional Animal Care and Use Committee. Eight adult female Beagle (mean age = 4.6 ± 0.6 yr; mean BW = 12.8 ± 1.7 kg) were used in a replicated 4 × 4 Latin square design. Each period consisted of 14 d, with 10 d of diet adaptation followed by 4 d of total fecal and urine collections. At the end of each period, a blood sample was collected and analyzed for serum chemistry. Food was offered twice daily and fed to maintain body weight. Food intake (g/d) on a dry matter basis (DMB) did not differ among treatments. Fecal score was lower (P < 0.05) for dogs fed CL (2.0) in contrast with other dietary treatments (2.3), using a 5-point scale (1 = hard, dry pellets; 5 = diarrhea). Fecal as-is and DM output did not differ for dogs fed BP, CL, or SBH, and were approximately 50% greater (P < 0.05) than dogs fed NF. Apparent total tract digestibility (ATTD) of dry matter, organic matter, and gross energy were greater (P < 0.05) for dogs fed NF when compared with dogs fed BP, CL, or SBH. Dogs fed CL had greater (P < 0.05) AHF ATTD (94%) compared with all other treatments (mean = 91%). Dogs fed CL and NF had greater (P < 0.05) CP ATTD, 87% and 86%, respectively, while dogs fed SBH were intermediate (83%) and dogs fed BP were lowest (79%). Total short-chain fatty acid (SCFA) concentration was greatest in dogs fed BP (582.5 μmol/g) and SBH (479.7 μmol/g) when compared with NF and CL (267.0 and 251.1 μmol/g, respectively). Serum metabolites were within-reference ranges and dogs remained healthy throughout the study. In conclusion, SBH resulted in similar macronutrient ATTD when compared with BP and CL. Dogs fed SBH were also observed to have an increase in fecal SCFA concentration. In general, high level addition of SBH were well-utilized by the dog, resulting in no untoward effects on dog health, nutrient digestibility, or fecal characteristics.
Potential use of carbocyclic nucleosides for the treatment of AIDS: chemo-enzymatic syntheses of the enantiomers of carbovir (1992)

The lactam (1R),(4S)-2-azabicyclo[2.2.1]hept-5-en-3-one [(–)-2], derived by whole cell enantio-specific hydrolysis of the racemate was converted into (–)-carbovir (–)-1 in ten steps. Lipase catalysed acetylation of 4-cis-hydroxycyclopent-2-enylmethyl triphenylmethyl ether afforded the optically pure ester (+)-3 and the alcohol (–)-9. The former compound was converted into (+)-carbovir (+)-1 in three steps.
How Can Companies Go Global? Global Integrators and the Global Mindset (1997)

Companies continue to look for better and faster ways to globalise. Organisation researchers have not yet identified the many possible integrators for globalising a company, particularly those which are most powerful. This study examines the literature relative to globalisation and presents the results of a survey of senior managers/HRD professionals of 20 global companies in Asia, Europe and the Americas
Functional role of NHE4 as a pH regulator in rat and human colonic crypts (2011)

To regulate ionic and fluid homeostasis, the colon relies upon a series of Na(+)-dependent transport proteins. Recent studies have identified a sodium/hydrogen exchanger (NHE) 4 (NHE4) protein in the gastrointestinal tract but to date there has been little description of its function. Additionally, we have previously shown that aldosterone can rapidly modulate Na(+)-dependent proton excretion via NHE proteins. In this study we examined the role of NHE4 in rat and human colonic crypts, determined the effect of aldosterone on NHE4 specifically, and explored the intracellular pathways leading to activation. Colonic samples were dissected from Sprague-Dawley rats. Human specimens were obtained from patients undergoing elective colon resections. Crypts were isolated using ethylenediaminetetraacetic acid and intracellular pH (pH(i)) changes were monitored using 2'-7'-bis(carboxyethyl)-5(6)-carboxyfluorescein (BCECF). Crypts were exposed to 7 μM ethylisopropylamiloride or 400 μM amiloride, doses previously shown to inhibit NHE1 and NHE3 but allow NHE4 to remain active. Functional NHE4 activity was demonstrated in both rat and human colonic crypts. NHE4 activity was increased in the presence of 1 μM aldosterone. In the rat model, crypts were exposed to 100 μM 3-isobutyl-1-methylxanthine/1 μM forskolin and demonstrated a decrease in NHE4 activity with increased cAMP levels. No significant change in NHE4 activity was seen by increasing osmolarity. These results demonstrate functional NHE4 activity in the rat and human colon and an increase in activity by aldosterone. This novel exchanger is capable of modulating intracellular pH over a wide pH spectrum and may play an important role in maintaining cellular pH homeostasis.
Continuous-wave operation of electrically pumped, single-mode, edge-emitting photonic crystal Bragg lasers (2007)

The authors demonstrate an electrically pumped, single-mode, large-area, edge-emitting InGaAsP∕InP two dimensional photonic crystal Bragg laser operating in continuous-wave condition. The laser uses a weak index perturbed, polymer-planarized, surface photonic crystal structure to control the optical mode in the wafer plane. They find that the laser operates in single transverse and longitudinal modes. They compare the performance of the photonic crystal Bragg laser with a broad-area laser fabricated from the same wafer and the comparison shows that the performance penalty incurred by the photonic crystal is small.
The association between tumour density and prostate cancer recurrence following radical prostatectomy (2013)

Purpose: Tumour density (TD) may be an independent prognosticfactor in men with prostate cancer. The purpose of this study wasto evaluate the association between prostate cancer TD and recurrencefollowing radical prostatectomy.Materials and Methods: Between 1995 and 2007, 645 patientsfrom The Ottawa Hospital or Memorial Sloan-Kettering CancerCenter who had cancer and prostate volumes measured from radicalprostatectomy specimens. Tumour density was defined as therelative tumour to prostate volume (tumour volume/prostate volume)and recurrence was defined as a prostate-specific antigen(PSA) &gt;0.2 ng/mL and rising, or postoperative use of radiation orhormonal therapy. Associations between TD and recurrence areadjusted for preoperative PSA, prostatectomy Gleason sum, tumourstage and margin status.Results: Median follow-up was 40.8 months. Tumour density wasassociated with preoperative PSA, Gleason sum, tumour stage andsurgical margin status (all p &lt; 0.0001). As a continuous variable,TD predicted recurrence-free survival (adjusted HR 1.34 per 10%increase in TD; p = 0.04). As a categorical variable, the groupof patients with a TD of &gt;10% had a 2.7 times greater hazard ofrecurrence compared to patients with a TD &lt;5% (95%CI 1.41,5.19; p = 0.003). Despite the independent association betweenTD and recurrence, the clinical value of TD remains in question asthe discriminative performance (area under the curve) of predictivemodels only improved from 0.865 to 0.876.Conclusions: Prostate cancer TD is associated with known prognosticfactors and is also independently predictive of recurrencefollowing radical prostatectomy.
Abstract 136 (2014)

AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK
Development of a Joule‐class Yb:YAG amplifier and its implementation in a CPA system generating 1 TW pulses (2014)

Abstract In this paper the development and implementation of a novel amplifier setup as an additional stage for the CPA pump laser of the Petawatt Field Synthesizer, currently developed at the Max‐Planck‐Institute of Quantum Optics, is presented. This amplifier design comprises 20 relay‐imaged passes through the active medium which are arranged in rotational symmetry. As the gain material, an in‐house‐developed Yb:YAG active‐mirror is used. With this setup, stretched 4 ns seed pulses are amplified to output energies exceeding 1 J with repetition rates of up to 2 Hz. Furthermore, a spectral bandwidth of 3.5 nm (FWHM) is maintained during amplification and the compression of the pulses down to their Fourier‐limit of 740 fs is achieved. To the best of our knowledge, this is the first demonstration of 1 TW pulses generated via CPA in diode‐pumped Yb:YAG.
Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties (2008)

Among the diverse sets of nicotinic acetylcholine receptors (nAChRs), the alpha7 subtype is highly expressed in the hippocampus and cortex and is thought to play important roles in a variety of cognitive processes. In this review, we describe the properties of a novel biaryl diamine alpha7 nAChR agonist, A-582941. A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS). In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation. A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit. A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function. The studies summarized in this review collectively provide preclinical validation that alpha7 nAChR agonism offers a mechanism with potential to improve cognitive deficits associated with various neurodegenerative and psychiatric disorders.
A 500 MHz to 6 GHz frequency synthesizer architecture for cognitive radio applications (2012)

This paper presents a frequency synthesizer architecture for cognitive radio applications designed to generate carrier frequencies spread into twelve bands distributed from 500 MHz to 6 GHz with a spacing of 500 MHz. At 4 GHz, the simulated phase noise is -110.8 dBc/Hz at a 1-MHz offset. The loop bandwidth of the PLL is of 575 kHz, and the switching time between bands is simulated to be of 5.75 ns.
Toward high‐resolution, inkjet‐printed, quantum dot light‐emitting diodes for next‐generation displays (2016)

Abstract We have investigated the possibility of fabricating quantum dot light‐emitting diodes (QLEDs) using inkjet printing technology, which is the most attractive method for the full‐color patterning of QLED displays. By controlling the quantum dot (QD) ink formulation and inkjet printing condition, we successfully patterned QLED pixels in the 60‐in ultrahigh definition TV format, which has a resolution of 73 pixels per inch. The inkjet‐printed QLEDs exhibited a maximum luminance of 2500 cd/m 2 . Although the performance of inkjet‐printed QLEDs is low compared with that of QLEDs fabricated using the spin‐coating process, our results clearly indicate that the inkjet printing technology is suitable for patterning QD emissive layers to realize high‐resolution, full‐color QLED displays.
Direct Light‐Driven Modulation of Luminescence from Mn‐Doped ZnSe Quantum Dots (2008)

Unlimited possibilities: Light-driven modulation of the fluorescence from Mn-doped ZnSe quantum nanocrystals has been established through excited-state absorption and its direct competition with spontaneous emission. Such optical control over electronic transitions enables far-field fluorescence microscopy analysis with diffraction-unlimited resolution (45 nm, red) based on quantum dots (confocal imaging has a resolution of 200 nm, blue). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z705111_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.