gebhart/patrepeval huggingface dataset:
Abstract 986: Reverse-engineered, forward-simulation of MEK-dependent molecular networks reveal novel regulators of cell cycle and cancer cell survival (2012)

Abstract ABSTRACT Molecular networks governing responses to targeted therapies in cancer cells are complex dynamic systems that demonstrate non-intuitive behaviors. We applied a novel computational strategy to decipher causal relationships between signaling network components. Gene networks were constructed MEK from global gene expression profiles to model G1-S cell cycle arrest as a consequence of inhibition of MEK, a key component of the oncogenic RAF-MEK-ERK signal transduction pathway. Through forward-simulation of reverse-engineered networks candidate MEK-dependent regulators of the cell cycle were identified. The potential of the approach to infer causality is demonstrated by confirmed predictions of differential effects of two early-response transcription factors, IER2 and EGR1. Conventional linear regression analysis shows strong correlation of expression of both with MEK inhibition and cell cycle distribution, while only IER2 is predicted by our model and experimentally validated to have a causal effect on G1-S transition. Furthermore, we identify TRIB1 (tribbles homologue 1 drosophila) as a potent and novel cell cycle regulator. TRIB1 also mediates cross-talk to the NFkB pathway by enhancing p100 and IkBa-phosphorylation and degradation thus regulating cell survival and expression of cytokines crucial for tumor-stroma interaction. In agreement with this, knock-down of TRIB1 results in induction of apoptosis and sensitizes cells to cell killing induced by the death-receptor agonist TRAIL via upregulation of TRAIL receptor, DR5. Thus TRIB1 is a central regulator of cell cycle and survival and represents a potential therapeutic target. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 986. doi:1538-7445.AM2012-986
Real-world-effectiveness von Dupilumab und Omalizumab bei schwerer chronischer Rhinosinusitis mit Polyposis (CRSwNP) (2023)

Einleitung Bei der CRSwNP handelt es sich um eine heterogene Erkrankung, welche hierzulande in 80% mit einer Entzündung vom Typ II einhergeht. Für die Behandlung der schweren Form der CRSwNP sind in Deutschland drei Biologika zugelassen. In der dieser Studie wurden Wirksamkeit und Verträglichkeit von Dupilumab und Omalizumab in der klinischen Anwendung untersucht und miteinander verglichen.
Low Acceleration Scanning Electron Microscope (1980)

A low acceleration scanning electron microscope ( LASEM ) offers several advantages: no charging effects low radiation damage high yield for secondary electron emission high sensitivity for surface topography The application of a low acceleration microscope, however, has been limited to special purposes because of its poor resolution. A high resolution LASEM has been developed and is shown in Fig.1. The microscope uses a new electron gun with a field emission cathode. The gun 1,000 times brighter than a conventional thermionic cathode. The relation between brightness and resolution of a SEM for 1 kV acceleration voltage is shown in Fig.2. The three regions in the figure correspond to tungsten thermionic, LaB6 thermionic and field emission guns. Resolution is approximately 1 μm in the case of the tungsten thermionic gun at 1 kV, while resolution is 200 A in the new microscope equipped with a field emission gun.
Contribution of Citrulline Ureidase toFrancisella tularensisStrain Schu S4 Pathogenesis (2009)

The citrulline ureidase (CTU) activity has been shown to be associated with highly virulent Francisella tularensis strains, including Schu S4, while it is absent in avirulent or less virulent strains. A definitive role of the ctu gene in virulence and pathogenesis of F. tularensis Schu S4 has not been assessed; thus, an understanding of the significance of this phenotype is long overdue. CTU is a carbon-nitrogen hydrolase encoded by the citrulline ureidase (ctu) gene (FTT0435) on the F. tularensis Schu S4 genome. In the present study, we evaluated the contribution of the ctu gene in the virulence of category A agent F. tularensis Schu S4 by generating a nonpolar deletion mutant, the Deltactu mutant. The deletion of the ctu gene resulted in loss of CTU activity, which was restored by transcomplementing the ctu gene. The Deltactu mutant did not exhibit any growth defect under acellular growth conditions; however, it was impaired for intramacrophage growth in resting as well as gamma interferon-stimulated macrophages. The Deltactu mutant was further tested for its virulence attributes in a mouse model of respiratory tularemia. Mice infected intranasally with the Deltactu mutant showed significantly reduced bacterial burden in the lungs, liver, and spleen compared to wild-type (WT) Schu S4-infected mice. The reduced bacterial burden in mice infected with the Deltactu mutant was also associated with significantly lower histopathological scores in the lungs. Mice infected with the Deltactu mutant succumbed to infection, but they survived longer and showed significantly extended median time to death compared to that shown by WT Schu S4-infected mice. To conclude, this study demonstrates that ctu contributes to intracellular survival, in vivo growth, and pathogenesis. However, ctu is not an absolute requirement for the virulence of F. tularensis Schu S4 in mice.
The HD12 Panel of the German Hodgkin Lymphoma Study Group (GHSG) (2004)

The purpose of this report is to determine the value of a central specialist radiologic review and to determine the image quality of computed tomography (CT) in Hodgkin disease. The HD12 protocol is a multicenter prospective randomized trial of the GHSG for advanced stages of Hodgkin disease. The indication and effectiveness of additional radiotherapy (30 Gy), in the area of initial bulky disease and of residual disease, following intensive chemotherapy using the BEACOPP schema (bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine, prednisone), is to be investigated. A multidisciplinary panel of radiation oncologists, radiologists, and medical oncologists reviews, blinded to treatment arms, the diagnostic imaging with comparison to the documentation forms. For patients with poor response to chemotherapy, the panel recommends radiotherapy independent of the randomization. This procedure guarantees that patients with a poor response to chemotherapy receive additional radiotherapy. Furthermore, the panel evaluates the quality of CT examinations in this multicenter study. Since July 1999, a total of 2607 CT of 371 patients have been evaluated. Helical CT showed significantly higher contrast enhancement and imaging quality than conventional CT (P < 0.001). CT from university hospitals was assessed as superior to that from other institutions (P < 0.001). Compared with the written disease documentation by the study centers, the panel assessed different extensions of disease in 814 of 2607 CT (31%), resulting in a change of stage in 17 of 371 patients (5%). After chemotherapy, 167 of 371 patients (45%) showed residual disease (>1.5 cm), and for 53 of 371 patients (14%) the panel recommended additional radiotherapy independent of the randomization arm. Patients with Hodgkin disease receive high-quality CT imaging. A central independent multidisciplinary panel markedly improves quality assurance for these study patients.
Spall Failure of ECAE Mg-Al Alloys at Extreme Strain Rates: Influence of a Refined Precipitate and Grain Microstructure (2023)

The development of advanced materials for extreme dynamic environments requires an understanding of the links between the microstructure and the response of the material (i.e., Materials-by-Design). Spall failure significantly limits material performance at high strain rates, but our understanding of the influence of microstructure on spall strength is limited. While models suggest that increasing the static yield strength by adding precipitates or refining grain size can improve the spall strength, it is possible that the associated increase in nucleation sites may have deleterious effects on spall performance. Herein, we examine spall failure of a Magnesium-Aluminum system with precipitation and grain size strengthening through novel high-throughput laser-driven micro-flyer (LDMF) impact experiments. Six microstructures are investigated, four with grain sizes around 2–3 μm and precipitates around 0.5–1 μm, and two that are precipitate-free with grain sizes around 500 μm at six and nine percent Aluminum contents. The LDMF method allows us to detect differences in spall strength with relatively small changes in microstructure. The spall strength is observed to be strongly affected by varying levels of precipitates and consistently shows a notable reduction in average spall strength around 8–19% with the addition of precipitates, with values ranging from 1.22–1.50 GPa. The spall strength is also seen to decrease with the refinement of grain size independent of composition. However, this decrease is small compared to the hundred-fold grain size reduction. While ductile void growth is observed across all samples, greater variability and a further decrease in strength are seen with an increasing numbers of non-uniformly dispersed precipitates.
Facile anhydride synthesis using trichlorotrifluoroacetone hydrate (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile anhydride synthesis using trichlorotrifluoroacetone hydrateSamy Abdel-Baky and Roger W. GieseCite this: J. Org. Chem. 1986, 51, 17, 3390–3391Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/jo00367a034https://doi.org/10.1021/jo00367a034research-articleACS PublicationsRequest reuse permissionsArticle Views517Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prioritizing regions of candidate genes for efficient mutation screening (2006)

The availability of the complete sequence of the human genome has dramatically facilitated the search for disease-causing sequence variations. In fact, the rate-limiting step has shifted from the discovery and characterization of candidate genes to the actual screening of human populations and the subsequent interpretation of observed variations. In this study we tested the hypothesis that some segments of candidate genes are more likely than others to contain disease-causing variations and that these segments can be predicted bioinformatically. A bioinformatic technique, prioritization of annotated regions (PAR), was developed to predict the likelihood that a specific coding region of a gene will harbor a disease-causing mutation based on conserved protein functional domains and protein secondary structures. This method was evaluated by using it to analyze 710 genes that collectively harbor 4,498 previously identified mutations. Nearly 50% of the genes were recognized as disease-associated after screening only 9% of the complete coding sequence. The PAR technique identified 90% of the genes as containing at least one mutation, with less than 40% of the screening resources that traditional approaches would require. These results suggest that prioritization strategies such as PAR can accelerate disease-gene identification through more efficient use of screening resources.
A Load-Balanced Parallel and Distributed Sorting Algorithm Implemented\n with PGX.D (2016)

Sorting has been one of the most challenging studied problems in different\nscientific researches. Although many techniques and algorithms have been\nproposed on the theory of having efficient parallel sorting implementation,\nhowever achieving desired performance on different types of the architectures\nwith large number of processors is still a challenging issue. Maximizing\nparallelism level in applications can be achieved by minimizing overheads due\nto load imbalance and waiting time due to memory latencies. In this paper, we\npresent a distributed sorting algorithm implemented in PGX.D, a fast\ndistributed graph processing system, which outperforms the Spark's distributed\nsorting implementation by around 2x-3x by hiding communication latencies and\nminimizing unnecessary overheads. Furthermore, it shows that the proposed PGX.D\nsorting method handles dataset containing many duplicated data entries\nefficiently and always results in keeping balanced workloads for different\ninput data distribution types.\n
Optimization of nonatitanate electrodes for sodium-ion batteries (2020)

NaTi<sub>3</sub>O<sub>6</sub>(OH)·2H<sub>2</sub>O, also known as “sodium nonatitanate” (NNT) can undergo reversible sodium (de)insertion at low potentials centered around 0.3 V.
Control of Quorum Sensing by a Burkholderia pseudomallei Multidrug Efflux Pump (2007)

ABSTRACT The Burkholderia pseudomallei KHW quorum-sensing systems produced N -octanoyl-homoserine lactone, N -decanoyl-homoserine lactone, N -(3-hydroxy)-octanoyl-homoserine lactone, N -(3-hydroxy)-decanoyl-homoserine lactone, N -(3-oxo)-decanoyl-homoserine lactone, and N -(3-oxo)-tetradecanoyl-homoserine lactone. The extracellular secretion of these acyl-homoserine lactones is dependent absolutely on the function of the B. pseudomallei BpeAB-OprB efflux pump.
PPAP: Perspective Projection Augment Platform with Pan–Tilt Actuation for Improved Spatial Perception (2019)

In this paper, we propose PPAP, an augmented reality platform with an actuated projector for dynamic user-perspective projection. In PPAP, a stationary camera is used jointly with a pan-tilt motorized projector-camera unit. With the servo control of the steerable pan-tilt system, the system is able to continuously orient itself to match the user's view center of the projection-mapped surface. This provides users with greatly widened viewing angles in the augmented scene, when compared to the stationary projection. Through user studies, in which users judged the size and distance of a projected virtual object, we verified that the perspective projection with the actuated projector helps users better understand the spatial relationship of the virtual object in the augmented scene in terms of depth perception.
A novel method to investigate defect states in MBE grown highly resistive GaN doped with C and Si (2005)

A novel method to characterize deep levels in wide bandgap, semi-insulating materials is presented. This new method combines deep level optical spectroscopy with a lighted capacitance-voltage profiling method to study the defect spectra of n-type and semi-insulating GaN co-doped with C and Si. Two prominent deep acceptor levels at EC – 2.54 and 3.28 eV are found to depend strongly on C incorporation. The relationship between the concentration of these defects and C incorporation offers insight into the mechanism responsible for rendering GaN:C semi-insulating. (© 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
RELATIONSHIP BETWEEN PERFORMANCE IN THE TIMED UP AND GO TEST AND PARTICIPATION OF BODY BALANCE MAINTENANCE SYSTEMS IN OLDER ADULT (2020)

Objective: Evaluate the relationship between performance in Timed Up and Go (TUG) and the participation of body balance maintenance systems in older adults. Methods: This paper present an observational cross-sectional analytical study of mobility and balance involving 62 participants (60 years and older), 40 female and 22 male, minimum 60 and maximum 96 years old, mean age 76,83 years (13,20 years). Each participant answered a questionnaire (sociodemographic and clinical characteristics) and performed two tests to assess mobility (TUG) and body balance (Sensory Organization Tests-SOT) using Dynamic Posturography Foam Laser (PFL). Tests with type I error below 5% were considered statistically significant and those between 5 and 10% were considered as statistical trend. We performed the data analysis using the Epi Info TM 7.2 program. Results: The vast majority of the elderly had average and high performance in TUG test (87%). Those with high performance were
Octreotide therapy for pancreaticopleural fistula (1994)

Pancreaticopleural fistula is a rare but remediable complication of pancreatitis. Hitherto, treatment by means of total parenteral nutrition and thoracocentesis had resulted in an overall success rate of 40% only. Surgical obliteration of persistent fistulae is required in many cases, as the underlying pancreatic duct lesion often prevents spontaneous closure of the fistula. We report a patient suffering from pancreaticopleural fistula with a tightly strictured pancreatic duct. The fistula was successfully obliterated with the use of octreotide addition to thoracocentesis and total parenteral nutrition. Pancreatic bypass surgery was later performed only for pain relief. We believe that octreotide can effectively suppress pancreatic secretion and promote closure of pancreaticopleural fistula even in the presence of severe pancreatic duct lesions. Thus the risk of infection and early surgery for persistent fistula can be minimized.
Molecular Imaging Techniques in Body Imaging (2007)

Molecular imaging of the body involves new techniques to image cellular biochemical processes, which results in studies with high sensitivity, specificity, and signal-to-background. The most prevalently used molecular imaging technique in body imaging is currently fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET). FDG PET has become the method of choice for the staging and restaging of many of the most common cancers, including lymphoma, lung cancer, breast cancer, and colorectal cancer. FDG PET has also become extremely valuable in monitoring the response to therapeutic drugs in many cancers. New PET agents, such as fluorothymidine and acetate, have also shown promise in the evaluation of response to therapy and in the staging of prostate cancer. Magnetic resonance (MR) spectroscopy has shown promise in the evaluation of prostate cancer. Breast cancer evaluation benefits from advances in spectroscopic imaging and contrast-enhanced kinetic evaluation of vascular permeability, which is altered in neoplastic processes because of release of angiogenic factors. Superparamagnetic iron oxide (SPIO) particles represent the first of an expanding line of MR contrast agents that target specific cellular processes. SPIO particles have also been used in the evaluation of the cirrhotic liver and at MR lymphangiography.
Comparing the self‐perceived effects of a facial anti‐aging product to those automatically detected from selfie images of Chinese women of different ages and cities (2021)

Such methodological approach paves the road in fulfilling the need of consumers of a better transparency in the claims of an anti-aging product.
Emergence of n-Type Characteristic of Conjugated Polymer Field-Effect Transistors with Calcium Source-Drain Electrodes (2004)

We fabricated field-effect transistors (FETs) using a highly soluble fluorene-based polymer as an active layer utilizing a low-work-function metal, calcium as a source-drain electrode material. The n-type characteristic of polymer FETs was successfully realized by lowering the electron injection barrier, although polymer FETs with gold source-drain electrodes did not exhibit n-type or p-type characteristic. The well-defined n-type FET provides a useful means of measuring the electron transport property of new organic semiconductors.
Deletion of virulence associated genes from attenuated African swine fever virus isolate OUR T88/3 decreases its ability to protect against challenge with virulent virus (2013)

African swine fever virus (ASFV) causes an acute haemorrhagic disease of domestic pigs against which there is no effective vaccine. The attenuated ASFV strain OUR T88/3 has been shown previously to protect vaccinated pigs against challenge with some virulent strains including OUR T88/1. Two genes, DP71L and DP96R were deleted from the OUR T88/3 genome to create recombinant virus OUR T88/3ΔDP2. Deletion of these genes from virulent viruses has previously been shown to reduce ASFV virulence in domestic pigs. Groups of 6 pigs were immunised with deletion virus OUR T88/3ΔDP2 or parental virus OUR T88/3 and challenged with virulent OUR T88/1 virus. Four pigs (66%) were protected by inoculation with the deletion virus OUR T88/3ΔDP2 compared to 100% protection with the parental virus OUR T88/3. Thus the deletion of the two genes DP71L and DP96R from OUR T88/3 strain reduced its ability to protect pigs against challenge with virulent virus.
Sliding control of discretized continuous systems via the Euler operator (2002)

The idea of "sliding mode control" (SMC) as a robust control method is utilized to control systems whose dynamics can be described by x(t)=(A+/spl Delta/A)x(t)+(B+/spl Delta/B)u(t)+d(t) where /spl Delta/A, /spl Delta/B and d(t) characterize unknown plant parameters and unexpected disturbances respectively. The design is described in the discrete form using the Euler operator, which approaches the Laplace operator as the sampling interval approaches zero. Uncertainty transformation from continuous to discrete time domain, which has not been adequately addressed in the control literature, is included throughout the analysis. Selection of the sliding surface, s=0, is not arbitrary but is dependent on the nominal parameters of the system and on the chosen sampling time. The control is constructed based on the estimation of system perturbations using time delay control. This methodology, towards SMC design, offers a robust control action which is continuous with possibly lower gains than the conventional "bang-bang" input, thus avoiding undesired chattering. Such issues are addressed and the asymptotic stability of the controlled system is analyzed. Finally the proposed controller is studied through simulations and experiment on a direct drive NSK robot arm. The results indicate that the controller is robust to parameter variations and unexpected disturbances.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Downlink power allocation algorithm for licence-exempt LTE systems using Kriging and Compressive Sensing based spectrum cartography (2013)

Licence-exempt secondary Long Term Evolution systems have been proposed recently, in attempt to meet the needs of rapidly growing wireless mobile applications. However, where the secondary network is spread over a large geographical area, traditional detect-and-avoid algorithms are less effective in providing interference protection to Primary Users while maximising the secondary throughput. Spectrum cartography is an emerging technique that can be used to discover spectrum holes in space. We propose a downlink power allocation algorithm using Kriging Spatial Interpolation and Compressive Sensing based spectrum cartography in an environment where large scale shadow fading is prominent. We evaluate the performance of our approach by simulating a secondary Urban Microcell network operating in TV White Space. Simulation results show a significant improvement in interference and throughput, in comparison to traditional detect-and-avoid algorithms.