gebhart/patrepeval huggingface dataset:
Risk Estimation of SARS-CoV-2 Transmission from Bluetooth Low Energy\n Measurements (2020)

Digital contact tracing approaches based on Bluetooth low energy (BLE) have\nthe potential to efficiently contain and delay outbreaks of infectious diseases\nsuch as the ongoing SARS-CoV-2 pandemic. In this work we propose a novel\nmachine learning based approach to reliably detect subjects that have spent\nenough time in close proximity to be at risk of being infected. Our study is an\nimportant proof of concept that will aid the battery of epidemiological\npolicies aiming to slow down the rapid spread of COVID-19.\n
Spatial Control of the Threshold Voltage of Low-Voltage Organic Transistors by Microcontact Printing of Alkyl- and Fluoroalkyl-phosphonic Acids (2011)

2011 International Conference on Solid State Devices and Materials,Spatial Control of the Threshold Voltage of Low-Voltage Organic Transistors by Microcontact Printing of Alkyl- and Fluoroalkyl-phosphonic Acids
Fast and scalable lipid nanoparticle formulation of niclosamide (nano NCM) effectively inhibits SARS-CoV-2 replication in vitro (2020)

As exemplified by the COVID-19 pandemic, highly infective respiratory viruses can spread rapidly in the population because of lack of effective approaches to control viral replication and spread. Niclosamide (NCM) is an old anthelminthic drug (World Health Organization essential medicine list) with pleiotropic pharmacological activities. Several recent publications demonstrated that NCM has broad antiviral activities and potently inhibits viral replication, including replication of SARS-CoV-2, SARS-CoV, and dengue viruses. Unfortunately, NCM is almost completely insoluble in water, which limits its clinical use. We developed a highly scalable and cost-effective nanoparticle formulation of NCM (nano NCM) using only FDA-approved excipient and demonstrated potency against SARS-CoV-2 infection in cells (Vero E6 and ACE2-expressing lung epithelium cells). Our ultimate goal is to develop the nano NCM formulation for treatment of COVID-19 patients.
Evidence of niche shift and global invasion potential of the Tawny Crazy ant, Nylanderia fulva (2015)

Analysis of an invasive species' niche shift between native and introduced ranges, along with potential distribution maps, can provide valuable information about its invasive potential. The tawny crazy ant, Nylanderia fulva, is a rapidly emerging and economically important invasive species in the southern United States. It is originally from east-central South America and has also invaded Colombia and the Caribbean Islands. Our objectives were to generate a global potential distribution map for N. fulva, identify important climatic drivers associated with its current distribution, and test whether N. fulva's realized climatic niche has shifted across its invasive range. We used MaxEnt niche model to map the potential distribution of N. fulva using its native and invaded range occurrences and climatic variables. We used principal component analysis methods for investigating potential shifts in the realized climatic niche of N. fulva during invasion. We found strong evidence for a shift in the realized climatic niche of N. fulva across its invasive range. Our models predicted potentially suitable habitat for N. fulva in the United States and other parts of the world. Our analyses suggest that the majority of observed occurrences of N. fulva in the United States represent stabilizing populations. Mean diurnal range in temperature, degree days at ≥10°C, and precipitation of driest quarter were the most important variables associated with N. fulva distribution. The climatic niche expansion demonstrated in our study may suggest significant plasticity in the ability of N. fulva to survive in areas with diverse temperature ranges shown by its tolerance for environmental conditions in the southern United States, Caribbean Islands, and Colombia. The risk maps produced in this study can be useful in preventing N. fulva's future spread, and in managing and monitoring currently infested areas.
The Versatile Stress Protein Mortalin as a Chaperone Therapeutic Agent (2009)

Age- and stress-induced modulations in chaperone systems result in "chaperono-deficiency" or "chaperon-opulence". Development of modulators, of chaperone function has therefore, become an emerging field in drug development and discovery. This mini-review summarizes (i) the events leading to identification of an Hsp70 family stress chaperone, mortalin, (ii) experimental evidence to its role in old age diseases and cancer, and (iii) proposes it as a chaperono-therapeutic agent. As post-translational modifications and expression changes in mortalin are being explored as a biomarker for cancer, cardiovascular diseases and neurodegeneration, we discuss here how the current tools used in studying mortalin (e.g. antibodies, peptides, ribozymes, antisense and siRNA, recombinant proteins and small molecules etc.) could be creatively applied in a clinical setting to manage stress and to treat various chaperone-based maladies or "chaperonopathies".
<title>Morphology of nanocrystalline titanium dioxide films</title> (1993)

The further morphological investigation of nanocrystalline TiO<SUB>2</SUB> films, which sensitized by suitable transition metal complexes forming a new type of molecular photovoltaic systems, the studies of new films and a new Co complexes are presented herein. Scanning electron microscopy, X-ray single crystal and powder diffraction as well as X-ray diffraction at low glancing angles using synchrotron radiation have been used. The morphology of electro- and thermodeposited Pt-layers on TCO (a), polymorphic composition of films (b), possible geometry of location of complex dye molecules on the exposed most faces of TiO<SUB>2</SUB> microcrystals (c) and the crystal structure of a Co(II) complex solvated by electrolyte 4- methyl-1,3-dioxolan-2-on as a precursor of the corresponding redox-system (d) are discussed.
Reconstructing vibrational states in warm molecules using four-wave mixing with femtosecond laser pulses (2007)

We propose a method to reconstruct the vibrational quantum state of molecules excited by a general excitation laser pulse. Unlike existing methods, we do not require the molecules before excitation to be in a pure state, allowing us to treat the important case of initially thermally excited molecules. Even if only a single initial level is appreciably populated, initial levels with small populations can still give major contributions to the unknown vibrational state, making it essential to take them into account. In addition to the excitation pulse, the method uses two incident, short laser pulses in a non-co-linear geometry to create four-wave mixing in the molecules. The measurements used in the reconstruction are spectra of the outgoing four-wave mixing pulse at different time delays of the excitation laser pulse. An important point is that the method does not require detailed knowledge of molecular transition moments between excited states nor of any of the incoming laser pulses, but circumvents this requirement by using one or more calibration laser pulses in a separate experiment either before or after the main data are recorded. The only requirements for the calibration laser pulses are that the constant parts of their spectrums should together cover the spectral range of the excitation laser pulse, and the constant part of each should have sufficient spectral overlap with one other calibration pulse to populate two of the same levels. Finally, we discuss the extension of the reconstruction method in this paper to more general situations, hereby presenting the new idea of quantum state reconstruction through perturbations with calibration.
Ultrafast Graphene Light Emitters (2018)

Ultrafast electrically driven nanoscale light sources are critical components in nanophotonics. Compound semiconductor-based light sources for the nanophotonic platforms have been extensively investigated over the past decades. However, monolithic ultrafast light sources with a small footprint remain a challenge. Here, we demonstrate electrically driven ultrafast graphene light emitters that achieve light pulse generation with up to 10 GHz bandwidth across a broad spectral range from the visible to the near-infrared. The fast response results from ultrafast charge-carrier dynamics in graphene and weak electron-acoustic phonon-mediated coupling between the electronic and lattice degrees of freedom. We also find that encapsulating graphene with hexagonal boron nitride (hBN) layers strongly modifies the emission spectrum by changing the local optical density of states, thus providing up to 460% enhancement compared to the gray-body thermal radiation for a broad peak centered at 720 nm. Furthermore, the hBN encapsulation layers permit stable and bright visible thermal radiation with electronic temperatures up to 2000 K under ambient conditions as well as efficient ultrafast electronic cooling via near-field coupling to hybrid polaritonic modes under electrical excitation. These high-speed graphene light emitters provide a promising path for on-chip light sources for optical communications and other optoelectronic applications.
Simulation of the Pyrolysis Process: from Plastic Waste to Environmental Friendly Fuel (2018)

How to deal with plastic waste is an important question, as it may affect both the climate and environment. A method that may be beneficial to dispose some kinds of plastic waste that cannot be material-recycled is thermochemical conversion and, more specifically, pyrolysis. To be able to optimize such a process models are important. This paper describes the results of a study where the main aim was to identify and compare existing published models identifying the important variables regarding the pyrolysis of Polyethylene (PE) and Polypropylene (PP), published in open literature, and to compare these methods with experimental data. Several models were found, of which three were chosen for implementation and further evaluation.
Comparison of Imaging Softwares for Upper Airway Evaluation: Preliminary Study (2017)

The interest about upper airway evaluation has increased lately. Therefore, many softwares have been developed aiming to improve and facilitate the analysis of airway volume. The objective of this study was to compare two different softwares packages, Mimics and Dolphin, in their accuracy and precision in upper airway space measurements. Preoperative cone beam computed tomography scans of nine nonsyndromic patients submitted to surgically assisted rapid maxillary expansion were included in this study. The imaging exams were converted to DICOM (digital imaging and communications in medicine) files and imported to the softwares. The mean volume for the Dolphin group (G1) was 10.791 cm <sup>3</sup> (SD = 4.269 cm <sup>3</sup> ) and for the Mimics group (G2) was 10.553 cm <sup>3</sup> (SD = 4.564 cm <sup>3</sup> ). There was no statistically significant difference between the two groups ( <i>p</i> = 0.105).
Unsupervised colorization of black-and-white cartoons (2004)

We present a novel color-by-example technique which combines image segmentation, patch-based sampling and probabilistic reasoning. This method is able to automate colorization when new color information is applied on the already designed black-and-white cartoon. Our technique is especially suitable for cartoons digitized from classical celluloid films, which were originally produced by a paper or cel based method. In this case, the background is usually a static image and only the dynamic foreground needs to be colored frame-by-frame. We also assume that objects in the foreground layer consist of several well visible outlines which will emphasize the shape of homogeneous regions.
Carrageenan as an Efficient Drug Release Modifier for Ethylcellulose-Coated Pharmaceutical Dosage Forms (2007)

ADVERTISEMENT RETURN TO ISSUEPREVNoteCarrageenan as an Efficient Drug Release Modifier for Ethylcellulose-Coated Pharmaceutical Dosage FormsFlorence Siepmann†, Susanne Muschert†, Stefanie Zach†, Bruno Leclercq‡, Brian Carlin§, and Juergen Siepmann*†View Author Information College of Pharmacy, JE 2491, University of Lille, 3 Rue du Professeur Laguesse, 59006 Lille, France, FMC BioPolymer, Avenue Mounier 83, 1200 Brussels, Belgium, and FMC BioPolymer, U.S. Route 1 & Plainsboro Road, Princeton, New Jersey 08543* To whom correspondence should be addressed. E-mail: [email protected]. Telephone: +33-3-20964708 . Fax: +33-3-20964942.†College of Pharmacy, JE 2491, University of Lille.‡FMC BioPolymer, Belgium.§FMC BioPolymer, USA.Cite this: Biomacromolecules 2007, 8, 12, 3984–3991Publication Date (Web):November 27, 2007Publication History Received28 August 2007Revised8 October 2007Published online27 November 2007Published inissue 1 December 2007https://pubs.acs.org/doi/10.1021/bm7009587https://doi.org/10.1021/bm7009587brief-reportACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views442Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Coating materials,Diffusion,Drug release,Pharmaceuticals,Polymer films Get e-Alerts
Self‐Assembling Peptide‐Based Nanoparticles for siRNA Delivery in Primary Cell Lines (2012)

The secondary amphipathic peptide CADY forms stable positively charged nanoparticles with short interfering RNA (siRNA), which involves both electrostatic and hydrophobic interactions. CADY/siRNA self-assembling nanoparticles adopt a “raspberry”-like architecture cemented together by a matrix of free peptides. These nanoparticles are nontoxic and promote efficient delivery of siRNA in challenging primary cell lines.
Inactivation of the Wwox Gene Accelerates Forestomach Tumor Progression In vivo (2007)

The WWOX gene encodes a tumor suppressor spanning the second most common human fragile site, FRA16D. Targeted deletion of the Wwox gene in mice led to an increased incidence of spontaneous and ethyl nitrosourea-induced tumors. In humans, loss of heterozygosity and reduced or loss of WWOX expression has been reported in esophageal squamous cell cancers (SCC). In the present study, we examined whether inactivation of the Wwox gene might lead to enhanced esophageal/forestomach tumorigenesis induced by N-nitrosomethylbenzylamine. Wwox+/- and Wwox+/+ mice were treated with six intragastric doses of N-nitrosomethylbenzylamine and observed for 15 subsequent weeks. Ninety-six percent (25 of 26) of Wwox+/- mice versus 29% (10 of 34) of Wwox+/+ mice developed forestomach tumors (P = 1.3 x 10(-7)). The number of tumors per forestomach was significantly greater in Wwox+/- than in Wwox+/+ mice (3.2 +/- 0.34 versus 0.47 +/- 0.17; P < 0.0001). In addition, 27% of Wwox+/- mice had invasive SCC in the forestomach, as compared with 0% of wild-type controls (P = 0.002). Intriguingly, forestomachs from Wwox+/- mice displayed moderately strong Wwox protein staining in the near-normal epithelium, but weak and diffuse staining in SCC in the same tissue section, a result suggesting that Wwox was haploinsufficient for the initiation of tumor development. Our findings provide the first in vivo evidence of the tumor suppressor function of WWOX in forestomach/esophageal carcinogenesis and suggest that inactivation of one allele of WWOX accelerates the predisposition of normal cells to malignant transformation.
Zhu Yao's Artistic Theory on Ancient Fu (2005)

Zhu Yao in his Genres of Ancient Fu first introduced the six artistic skills of Feng,Fu,Bi,Xing,Ya,and Song into Fu criticism and claimed that the means of artistic expression in ancient Fu are characterized by the combined use of Fu and Bi,and by involvement of emotion,literary grace and reason.Zhu Yao's theory on Fu,together with his theories of Fu ontology and development,constitutes his theory on ancient Fu.According to Zhu,emotion is the foundation,more important than reason,and reason is derived from language,and this literary theory is a summarization of the emotion-language theory of the Six Dynasties,and the emotion-reason theory and the language-reason theory of the Song Dynasty.Zhu launched a new trend for literary theories appearing since the Ming Dynasty and his theory thus has a very important position in the history of Chinese literary criticism.
Chen, Wang, and Mazur reply (1989)

Received 12 September 1988DOI:https://doi.org/10.1103/PhysRevLett.63.1534©1989 American Physical Society
Ultralow phase noise dual-loop optoelectronic oscillator (2002)

Summary form only given. We have designed, built, and characterized a double-loop optoelectronic oscillator (OEO) operating at 10 GHz. The OEO has achieved an unsurpassed low phase noise of -140 dBc/Hz at 10 kHz away from the carrier. More than 30 dB close-in phase noise reduction is expected using a novel noise reduction technique. Such a low phase noise oscillator can find wide applications in radar systems, microwave photonic systems, fiber-optic communication systems, and high-speed analog to digital conversion systems.
Bone Regeneration in a Rabbit Critical-Sized Calvarial Model Using Tyrosine-Derived Polycarbonate Scaffolds (2012)

Porous three-dimensional tyrosine-derived polycarbonate (TyrPC) scaffolds with a bimodal pore distribution were fabricated to mimic bone architecture using a combination of salt-leaching and phase separation techniques. TyrPC scaffolds degraded in register with bone regeneration during the 6-week study period and compressive moduli of the scaffolds were maintained >0.5 MPa at 6 weeks of incubation in PBS at 37 °C. The TyrPC scaffolds either unsupplemented or supplemented with recombinant human bone morphogenetic protein-2 (rhBMP-2) were implanted in a rabbit calvarial critical-sized defect (CSD) model and the TyrPC scaffolds treated with rhBMP-2 or TyrPC coated with calcium phosphate scaffold alone promoted bone regeneration in a rabbit calvarial CSD at 6 weeks postimplantation. A synthetic TyrPC polymeric scaffold either without a biological supplement or with a minimal dose of rhBMP-2 induced bone regeneration comparable to a commercially available bone graft substitute in a nonrodent CSD animal model.
Bi-Linear Regression for 18O Quantification: Modeling across the Elution Profile (2010)

MOTIVATION: Interpreting and quantifying labeled mass-spectrometry data is complex and requires automated algorithms, particularly for large scale proteomic profiling. Here, we propose the use of bi-linear regression to quantify relative abundance across the elution profile in a unified model. The bi-linear regression model takes advantage of the fact that while peptides differ in overall abundance across the elution profile multiplicatively, the relative abundance between the mixed samples remains constant across the elution profile. We describe how to apply bi-linear regression models to (18)O stable-isotope labeled data, which allows for the direct comparison of two samples simultaneously. Interpretation of model parameters is also discussed. The incorporation rate of the labeling isotope is estimated as part of the modeling process and can be used as a measure of data quality. Application is demonstrated in a controlled experiment as well as in a complex mixture. RESULTS: Bi-linear regression models allow for more precise and accurate estimates of abundance, in comparison to methods that treat each spectrum independently, by taking into account the abundance of the molecule throughout the entire elution profile, with precision increased by one-to-two orders of magnitude.
Spatial filtering of unipolar electrograms (2002)

In order to be able to derive some quantitative criteria to assist in making decisions about the presence of local activations, zones of canine myocardium incapable of undergoing electrical activation (EA) were created. The criteria are based on the comparison of electrograms recorded in those inexcitable zones with electrograms recorded in normal myocardium. Two criteria for making decisions about local EA in unipolar electrograms are compared. The first is based on the first time derivative (time filtering) of the electrogram and the second is based on th first spatial derivative (spatial filtering) between two electrograms recorded in neighboring electrodes. It is shown that the spatial derivative performs much better than the time derivative in both supraventricular rhythm and ventricular fibrillation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The erbium micropeel: a prospective, randomized trial of the effects of two fluence settings on facial photoaging. (2011)

Both settings resulted in moderate but significant improvement in dyschromia, although only HF treatment improved rhytides. The decreased downtime of LF treatments made this the preferred choice of patients.
Association of serum antioxidants and risk of coronary heart disease in South Indian population. (2004)

The results of present study suggest that deficiency of vitamin E may be an independent risk factor of CHD. This study brings out the need for long- term monitoring of vitamin E supplementation as a preventive measure for CHD in the population studied.
Synthesis, Properties, and Derivatization of Poly(dihydrogermane): A Germanium-based Polyethylene Analogue (2020)

Polygermanes are germanium-based analogues of polyolefins and possess polymer backbones made up catenated Ge atoms. In the present contribution we report the preparation of a stable germanium polyethylene analogue – polydihydrogermane (i.e., (GeH2)n) – via two straightforward approaches that involve topotactic deintercalation of the CaGe Zintl phase. The resulting (GeH2)n possess morphologically dependent chemical and electronic properties and thermally decompose to yield amorphous hydrogenated Ge. We also show that the resulting (GeH2)n provide a platform from which functionalized polygermanes can be prepared via thermally-induced hydrogermylation-mediated pendant group substitution. This facile one-step derivatization reaction exploits Ge–H reactivity and opens the door to a wide array of tailored functional polygermanes.