gebhart/patrepeval huggingface dataset:
Effects and Satisfaction of Medical Device Safety Information Reporting System Using Electronic Medical Record (2017)

We were able to verify that effective reporting and monitoring of adverse incidents and the safety of medical devices can be implemented through the establishment of an in-hospital medical device safety information reporting system that can enhance patient safety and medical device risk management.
A Proactive Construction Management Approach to Minimize Construction Claims (2006)

All stages of Project are important, starting from planning to design to contract award to construction to operation and maintenance. There is a special interaction which should take place amongst Owner, Designer and Construction Manager (CM) before the advertisement/ award of any contract. This paper is about claims avoidance, not the constructability review. There are certain sections of the specifications and general requirements which need special and very important input from the CM before the contract advertisement for bid, to avoid/ minimize claims. The Owner should strongly consider them. This paper starts from the timeline of the involvement of Resident Engineer (RE) during the design stage; focuses on providing input on the specific elements of the specifications; defines specific responsibility of the RE; Inspector’s role, his /her daily dairy and its closure with contractor’s daily dairy; documents control person’s role; scheduler’s role; Owner’s role; specifies method of project control and monitoring; meetings; project documentation and correspondence utilizing available standard construction management computer software; single point of contact; expectations from the contractor etc. There will be some details on the implementation and enforcement of the contract documents. It is assumed that the designer’s role is technical accuracy of the specifications and drawings. The paper provides specific recommendations for the changes to the contract documents (before contract advertisement) to the general requirements, special provisions and various sections of specifications Division 1 such as measurement and payments; specific schedule details required from the contractor; change order format and process; profits variations in terms of level of difficulty using risk factor analysis; specific schedule of values; predefined master submittals list; material, labor quantities requirements; audit process and timeline; few controlling factors; cost and manpower loaded schedule; roll up of construction work progress to the baseline schedule and pay application; negotiations rules; joint field visits etc. (Note: Scope change is not considered as the claim). The paper found that by adding extra CM activities as an integral part of the project after 85% design stage and before contract advertisement and incorporating their recommendations will save significant costs in the form of claims avoidance. Most claims are due to lack of proper documentations; delay in processing the documents; making late decisions by Owner; CM’s limitations in making decisions; conflicting/multiple confusing directions to the Contractor from various Owner and Designer’s representatives overriding RE’s authority; and lack of specific requirements in the contract documents. There is a mixed project management culture found in the industry at the current age. The author will try to define a solution to these issues to avoid claims. There is a huge undefined savings expected in the form of project claims avoidance.
CCSW'16: 8th ACM Cloud Computing Security Workshop (2016)

Cloud computing is a dominant trend in computing for the foreseeable future; e.g., major cloud operators are now estimated to house over a million machines each and to host substantial (and growing) fractions of our IT and web infrastructure. CCSW is a forum for bringing together researchers and practitioners to discuss the implications of this trend to the security of cloud operators, tenants, and the larger Internet community. CCSW welcomes submissions on new threats, countermeasures, and opportunities brought about by the move to cloud computing, with a preference for unconventional approaches, as well as measurement studies and case studies that shed light on the security implications of clouds.
17β-Hydroxysteroid Dehydrogenase from Human Red Blood Cells (1968)

Abstract 17β-Hydroxysteroid dehydrogenase has been isolated from human red cells and purified 740 times. The enzyme is sensitive to ionic strength and is most effective at sodium chloride concentrations of 0.1 m and above. 17β-Estradiol 3-sulfate reacts at a faster rate than 17β-estradiol. The Km for estradiol is 9.1 x 10-5, and for estradiol sulfate it is 3.8 x 10-4. The free compound has a pH optimum of 9.7; the sulfate reacts optimally at pH 9.0. The enzyme is specific for TPN; DPN shows one-sixth to one-tenth as much activity. The Km values for TPN are 2.7 x 10-5 with estradiol and 2.4 x 10-5 with estradiol sulfate. Acetyl-TPN is less active than TPN. Albumin inhibits the reaction, presumably by binding the steroids. Organic solvents also act inhibitorily. The enzyme appears to be of the sulfhydryl type. Enzyme activity was assayed by measurement of TPNH produced and by yield of estrone. Reduction of estrone or its sulfate occurs at slower rates than the corresponding reverse reactions. The molecular weight of the enzyme, calculated from mobility data on Sephadex gel, is approximately 75,500.
Polypropylene Carbonate-Based Adaptive Buffer Layer for Stable Interfaces of Solid Polymer Lithium Metal Batteries (2019)

Solid polymer electrolytes (SPEs) have the potential to enhance the safety and energy density of lithium batteries. However, poor interfacial contact between the lithium metal anode and SPE leads to high interfacial resistance and low specific capacity of the battery. In this work, we present a novel strategy to improve this solid-solid interface problem and maintain good interfacial contact during battery cycling by introducing an adaptive buffer layer (ABL) between the Li metal anode and SPE. The ABL consists of low molecular-weight polypropylene carbonate , poly(ethylene oxide) (PEO), and lithium salt. Rheological experiments indicate that ABL is viscoelastic and that it flows with a higher viscosity compared to PEO-only SPE. ABL also has higher ionic conductivity than PEO-only SPE. In the presence of ABL, the interface resistance of the Li/ABL/SPE/LiFePO<sub>4</sub> battery only increased 20% after 150 cycles, whereas that of the battery without ABL increased by 117%. In addition, because ABL makes a good solid-solid interface contact between the Li metal anode and SPE, the battery with ABL delivered an initial discharge specific capacity of >110 mA·h/g, which is nearly twice that of the battery without ABL, which is 60 mA·h/g. Moreover, ABL is able to maintain electrode-electrolyte interfacial contact during battery cycling, which stabilizes the battery Coulombic efficiency.
ChemInform Abstract: Exploring Computational Design of Size‐Specific Subnanometer Clusters Catalysts (2012)

Abstract Review: 245 refs.
Probing Polytopic Membrane Protein–Substrate Interactions by Luminescence Resonance Energy Transfer (2016)

Integral membrane proteins play essential roles in all living systems; however, major technical hurdles challenge analyses of this class of proteins. Biophysical approaches that provide structural information to complement and leverage experimentally determined and computationally predicted structures are urgently needed. Herein we present the application of luminescence resonance energy transfer (LRET) for investigating the interactions of the polytopic membrane-bound oligosaccharyl transferases (OTases) with partner substrates. Monomeric OTases, such as the PglBs from Campylobacter jejuni and Campylobacter lari, catalyze transfer of glycans from membrane-associated undecaprenol diphosphate-linked substrates to proteins in the bacterial periplasm. LRET-based distance measurements are enabled by the inclusion of an encoded N-terminal lanthanide-binding tag (LBT), and LRET between the luminescent (LBT)-Tb(3+) donor complex and fluorescently labeled peptide and glycan substrates provides discrete distance measurements across the span of the membrane. LRET-based measurements of detergent-solubilized PglB from C. lari allowed direct comparison with the distances based on the previously reported the C. lari PglB crystal structure, thereby validating the approach in a defined system. Distance measurements between peptide and glycan substrates and the C. jejuni PglB offer new experimental information on substrate binding to the related, but structurally uncharacterized, eukaryotic OTase.
The use of poly (isobutyl cyanoacrylate) nanoparticles with selected antifungal drugs (1987)

The effect of degrading drug carrier poly (isobutyl cyanoacrylate) nanoparticles (NPs) on amphotericin B, 5-fluorocytosine, and miconazole was studied by testing minimal inhibitory concentrations (MICs) of these drugs against &lt;it&gt;Candida albicans&lt;/it&gt; with or without the presence of NPs. Amphotericin B was destroyed by degrading NPs, however, there was no effect on the other two drugs. The results caution the use of NPs as carriers for amphotericin B for treatment of mycotic infections.
Freestanding fiber mats of zeolitic imidazolate framework 7 via one‐step, scalable electrospinning (2016)

ABSTRACT We demonstrated the fabrication of freestanding zeolitic imidazolate framework 7 (ZIF‐7) nanofiber (NF) mats by means of one‐step, scalable electrospinning. The formation of ZIF‐7 nanoparticles embedded in polymer fibers was unambiguously pinpointed via X‐ray diffraction, transmission electron microscopy, and adsorption studies. The NF mats exhibited excellent characteristics, with an average diameter of 245 nm, in the adsorption and desorption of carbon dioxide (CO 2 ); this makes them attractive candidates for gas separation and other selective filtration applications. This excellent property of the ZIF‐7 mats was explained by the gate‐opening phenomenon of ZIF‐7, which yielded a stepwise increase in the overall CO 2 uptake capacity. The mechanical strength of the NF mats was also obtained via large‐strain uniaxial tensile deformation, which enabled preliminary assessment of the mat's suitability for textiles and membranes in targeting separation and filtration applications with large‐area permeability. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43788.
Liver-targeted disruption ofApcin mice activates β-catenin signaling and leads to hepatocellular carcinomas (2004)

Although inappropriate activation of the Wnt/beta-catenin pathway has been implicated in the development of hepatocellular carcinoma (HCC), the role of this signaling in liver carcinogenesis remains unclear. To investigate this issue, we constructed a mutant mouse strain, Apc(lox/lox), in which exon 14 of the tumor-suppressor gene adenomatous polyposis coli (Apc) is flanked by loxP sequences. i.v. injection of adenovirus encoding Cre recombinase (AdCre) at high multiplicity [10(9) plaque-forming units (pfu) per mouse] inactivated the Apc gene in the liver and resulted in marked hepatomegaly, hepatocyte hyperplasia, and rapid mortality. beta-Catenin signaling activation was demonstrated by nuclear and cytoplasmic accumulation of beta-catenin in the hepatocytes and by the induction of beta-catenin target genes (glutamine synthetase, glutamate transporter 1, ornithine aminotransferase, and leukocyte cell-derived chemotaxin 2) in the liver. To test a long-term oncogenic effect, we inoculated mice with lower doses of AdCre (0.5 x 10(9) pfu per mouse), compatible with both survival and persistence of beta-catenin-activated cells. In these conditions, 67% of mice developed HCC. beta-Catenin signaling was strongly activated in these Apc-inactivated HCCs. The HCCs were well, moderately, or poorly differentiated. Indeed, their histological and molecular features mimicked human HCC. Thus, deletion of Apc in the liver provides a valuable model of human HCC, and, in this model, activation of the Wnt/beta-catenin pathway by invalidation of Apc is required for liver tumorigenesis.
Theoretical and experimental determination of surface susceptibility of switchable terahertz metasurfaces (2016)

We describe experimental characterization of switchable terahertz metasurfaces using broadband ellipsometry. A theoretical framework based on generalized sheet transition conditions is developed to extract surface susceptibility as a function of frequency and applied DC bias. This will allow us to make a priori predictions of the performance of these switchable devices in device applications, enabling rational design of active components.
Design and topology/shape structural optimisation for additively manufactured cold sprayed components (2013)

Integrating advanced structural optimisation, such as topology optimisation (TO), with additive manufacturing (AM) allows design and fabrication of extremely efficient and effective components. Such integration is challenging because characteristics can vary from process to process. In this paper, designing and optimising a part for the cold spray AM process is demonstrated. Cold spray process characteristics and constraints are enforced throughout. The analysis shows a tradeoff between stress and mass, but the combined process delivers a structure at much lower stress (up to 3X reduction in peak stress in a case study) with the capability to be much lighter than the original part (case study: 20% reduction in weight). The general approach to specifying design guidelines, interpreting TO results, and applying other structural optimisation methods is directly applicable to many AM processes – and especially other spray deposition techniques – in addition to cold spray.
Paraneoplastic Pemphigus Associated with Malignant Gastrointestinal Stromal Tumour (2010)

© 2010 The Authors. doi: 10.2340/00015555-0739 Journal Compilation © 2010 Acta Dermato-Venereologica. ISSN 0001-5555 Sir, Paraneoplastic pemphigus (PNP) is an autoimmune bullous disease characterized by severe mucous membrane involvement, polymorphous skin eruptions, and underlying neoplasms. Most cases are associated with lymphoproliferative neoplasms, and solid tumours have rarely been associated with PNP (1, 2). We describe here a patient with PNP associated with malignant gastrointestinal stromal tumour (GIST).
Engineering ideal helical topological networks in stanene via Zn decoration (2022)

The xene family of topological insulators plays a key role in many proposals for topological electronic, spintronic, and valleytronic devices. These proposals rely on applying local perturbations, including electric fields and proximity magnetism, to induce topological phase transitions in xenes. However, these techniques lack control over the geometry of interfaces between topological regions, a critical aspect of engineering topological devices. We propose adatom decoration as a method for engineering atomically precise topological edge modes in xenes. Our first-principles calculations show that decorating stanene with Zn adatoms exclusively on one of two sublattices induces a topological phase transition from the quantum spin Hall (QSH) to quantum valley Hall (QVH) phase and confirm the existence of spin-valley polarized edge modes propagating at QSH/QVH interfaces. We conclude by discussing technological applications of these edge modes that are enabled by the atomic precision afforded by recent advances in adatom manipulation technology.
ChemInform Abstract: Synthesis of Chiral Piperazinones as Versatile Scaffolds for Peptidomimetics. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Impact of Surgeon and Surgical Team on Outcomes in Immediate Implant Based Breast Reconstruction (2014)

BACKGROUND: Outcome studies of immediate implant based breast reconstruction (IBR) have largely focused on patient factors, while the relative impact of the surgeon as a contributing variable is not known. In particular, when the procedure requires collaboration of both a surgical oncologist and plastic surgeon, the effect of the surgeon team interaction can have significant impact on outcome. This study examines outcomes in IBR and the association with patient characteristics, surgeon, and surgeon team familiarity. METHODS: A retrospective review of 3,142 consecutive IBR mastectomy procedures at one institution was performed. Infection rate, skin necrosis and local recurrence were measured. Predictors of outcomes were identified by unadjusted logistic regression followed by multivariate logistic regression. Surgeon teams (oncologic plus reconstructive surgeon) were grouped according to number of cases performed together. RESULTS: Patient characteristics remain the most important predictors for outcomes in IBR, with odds ratios above that of surgeon variables. We observed significant differences in rate of skin necrosis between surgical oncologists with approximately two-fold difference between surgeons with the highest and lowest rates (Table 1).Table 1: Multivariate Analysis for skin necrosis and infection. Abbreviations: OR, Odds ratio; ADM, Acellular Dermal Matrix.1 Reconstruction with Tissue Expander2 Bilateral procedure.Surgeon teams that worked together on less than 150 procedures had higher rates of infection (OR=2.48, p<0.05) (Table 2).Table 2: Multivariate Analysis Teams for skin necrosis and infection. Abbreviations: OR, Odds ratio. 1Reconstruction with Tissue Expander 2Bilateral procedure.CONCLUSION: Patient characteristics are the most important predictors for surgical outcomes in IBR, but surgeons and surgeon teams are also important variables. High-volume surgeon teams achieve lower rates of infection. This study highlights the need to examine modifiable risk factors associated with optimum IBR outcomes, which include patient and provider characteristics as well as the surgical team treating the patient.
In vivo [Fe‐S] cluster acquisition by IscR and NsrR, two stress regulators in Escherichia coli (2013)

The multi-proteins Isc and Suf systems catalyse the biogenesis of [Fe-S] proteins. Here we investigate how NsrR and IscR, transcriptional regulators that sense NO and [Fe-S] homeostasis, acquire their [Fe-S] clusters under both normal and iron limitation conditions. Clusters directed at the apo-NsrR and apo-IscR proteins are built on either of the two scaffolds, IscU or SufB. However, differences arise in [Fe-S] delivery steps. In the case of NsrR, scaffolds deliver clusters to either one of the two ATCs, IscA and SufA, and, subsequently, to the 'non-Isc non-Suf' ATC, ErpA. Nevertheless, a high level of SufA can bypass the requirement for ErpA. In the case of IscR, several routes occur. One does not include assistance of any ATC. Others implicate ATCs IscA or ErpA, but, surprisingly, SufA was totally absent from any IscR maturation pathways. Both IscR and NsrR have the intrinsic capacity to sense iron limitation. However, NsrR appeared to be efficiently matured by Isc and Suf, thereby preventing NsrR to act as a physiologically relevant iron sensor. This work emphasizes that different maturation pathways arise as a function of the apo-target considered, possibly in relation with the type of cluster, [2Fe-2S] versus [4Fe-4S], it binds.
Gamma subunit of complement component 8 is a neuroinflammation inhibitor (2020)

The complement system is part of the innate immune system that comprises several small proteins activated by sequential cleavages. The majority of these complement components, such as components 3a (C3a) and C5a, are chemotactic and pro-inflammatory. However, in this study, we revealed an inhibitory role of complement component 8 gamma (C8G) in neuroinflammation. In patients with Alzheimer's disease, who exhibit strong neuroinflammation, we found higher C8G levels in brain tissue, CSF, and plasma. Our novel findings also showed that the expression level of C8G increases in the inflamed mouse brain, and that C8G is mainly localized to brain astrocytes. Experiments using recombinant C8G protein and shRNA-mediated knockdown showed that C8G inhibits glial hyperactivation, neuroinflammation, and cognitive decline in acute and chronic animal models of Alzheimer's disease. Additionally, we identified sphingosine-1-phosphate receptor 2 (S1PR2) as a novel interaction protein of C8G and demonstrated that astrocyte-derived C8G interacts with S1PR2 to antagonize the pro-inflammatory action of S1P in microglia. Taken together, our results reveal the previously unrecognized role of C8G as a neuroinflammation inhibitor. Our findings pave the way towards therapeutic containment of neuroinflammation in Alzheimer's disease and related neurological diseases.
Apache airavata (2011)

In this paper, we introduce Apache Airavata, a software framework to compose, manage, execute, and monitor distributed applications and workflows on computational resources ranging from local resources to computational grids and clouds. Airavata builds on general concepts of service-oriented computing, distributed messaging, and workflow composition and orchestration. This paper discusses the architecture of Airavata and its modules, and illustrates how the software can be used as individual components or as an integrated solution to build science gateways or general-purpose distributed application and workflow management systems.
Homocoupling of Phenylboronic Acid using Atomically Dispersed Gold on Carbon Catalysts: Catalyst Evolution Before Reaction (2017)

Abstract Coupling reactions to form new C−C bonds are extensively used in industrial synthetic processes. Gold has been shown to be an active catalyst for such reactions; however, conflicting reports exist as to whether cationic Au or metallic Au acts as the active species. We prepared a heterogeneous catalyst consisting of atomically dispersed Au–Cl x supported on carbon and showed this to be active in the homocoupling of phenylboronic acid to biphenyl. However; characterisation of the catalyst materials, even after just a short exposure time to the reactants, revealed rapid reduction and sintering of the Au species into larger metallic nanoparticles, which we propose to be the true active species in this instance. This study suggests that if cationic Au is an active catalyst, it must be stabilised against reduction and agglomeration by either forming complexes which are more stable than common chlorides or by strongly anchoring them firmly onto alternative support materials; as in this case the carbon supported Au–Cl species were easily reduced.
Vacuum field induced mixing of light and heavy-hole excitons in a semiconductor microcavity (1996)

Measurements in a semiconductor microcavity reveal the coupling between light- and heavy-hole excitons that is mediated by the electromagnetic vacuum. Three polariton modes constructed from superpositions of heavy-hole excitons, light-hole excitons, and photons are observed. The experimental results are in good agreement with the theory of three-coupled bosonic modes, each coupled to an independent reservoir.
Cytarabine with high-dose mitoxantrone induces rapid complete remissions in adult acute lymphoblastic leukemia without the use of vincristine or prednisone. (1996)

This dose-intense induction regimen produced a high incidence of CRs with acceptable toxicity without the use of vincristine or corticosteroids. Comparisons with our prior vincristine/prednisone-based induction regimen (the L-20 protocol) suggest that patients treated on the current study were more likely to achieve a CR and that they achieved this remission earlier than patients treated with a traditional four-drug (vincristine, prednisone, doxorubicin, and cyclophosphamide) induction regimen.