gebhart/patrepeval huggingface dataset:
Energy Storage: Reversibly Compressible, Highly Elastic, and Durable Graphene Aerogels for Energy Storage Devices under Limiting Conditions (Adv. Funct. Mater. 7/2015) (2015)

Reversibly compressible and durable graphene aerogels are demonstrated by J. Kong, H. S. Park, and colleagues on page 1053 for energy storage where volume and mass must be limited. Taking advantage of the polymer assisted self assembly and cross linking, high porosity and low density yet mechanical durability and elasticity are achieved in cross linked reduced graphene oxide aerogels. They are highly and reversibly compressible while maintaining 3D interconnecting networked pathways for applications in ultra compact electrochemical capacitors.
Efficacy of next line of therapy after treatment with lenvatinib (LEN) in combination with pembrolizumab (pembro) versus treatment of physician’s choice (TPC) in patients (pts) with advanced endometrial cancer (aEC): Exploratory analysis of Study 309/KEYNOTE-775. (2022)

5587 Background: In the multicenter, open-label, randomized, phase 3 Study 309/KEYNOTE-775, LEN + pembro had significant PFS and overall survival benefits, and improved objective response rate vs TPC in pts with aEC following systemic platinum-based treatment (Makker 2022, NEJM). These results were seen in all-comer pts and in pts with DNA mismatch repair proficient (pMMR) disease. Here, we assessed PFS on next line of therapy (PFS2) of each arm. Methods: Pts with aEC and 1 prior platinum-based chemotherapy regimen (or up to 2 if 1 was given in neoadjuvant/adjuvant setting) were randomized (1:1) to receive LEN 20 mg orally QD + pembro 200 mg IV Q3W or TPC (doxorubicin at 60 mg/m 2 IV Q3W or paclitaxel at 80 mg/m 2 IV QW [3 weeks on; 1 week off]). Randomization was stratified by MMR status (determined centrally); pts with pMMR tumors were further stratified by Eastern Cooperative Oncology Group performance status, geographic region, and history of pelvic radiation. In this prespecified exploratory analysis, PFS2 (defined as the time from randomization to disease progression on next line of treatment or death, whichever came first) was analyzed per investigator assessment in the pMMR and all-comer populations. Results: 827 Pts (pMMR, n=697; MMR deficient [dMMR], n=130) were randomized to LEN + pembro (n=411) or TPC (n=416). At data cutoff (October 26, 2020), 567 pts (LEN + pembro, n=282; TPC, n=285) had discontinued study treatment and 315 (LEN + pembro, n=115; TPC, n=200) had received a subsequent systemic anticancer therapy (Table): most commonly doxorubicin (n=58) in the LEN + pembro arm and paclitaxel (n=57) in the TPC arm. Median PFS2 was longer in the LEN + pembro arm vs the TPC arm in the pMMR population (14.4 vs 9.8 mo; HR 0.62, 95% CI 0.50–0.75) and in the all-comer population (16.0 vs 9.5 mo; HR 0.56, 95% CI 0.46–0.67). Additionally, the PFS2 rate at 6 months favored LEN + pembro vs TPC in the pMMR population (82.0% vs 74.8%) and in the all-comer population (81.7% vs 72.5%). Conclusions: Clinically meaningful improvements in PFS2 were seen in the LEN + pembro group compared with TPC in pMMR and all-comer pts. Clinical trial information: NCT03517449. [Table: see text]
Efficiency contours and loss minimization over a driving cycle of a variable-flux flux-intensifying interior permanent magnet machine (2013)

In this paper, experimental evaluations for the efficiency of a novel interior permanent magnet (IPM) machine with variable-flux characteristics using low coercive force magnets is presented. The variable-flux characteristics allow improving the efficiency of machine and also reducing the usage of rare-earth material in the high-coercive magnets, which are currently used for the IPM machines in electrified vehicles. A flux-intensifying interior permanent magnet (FI-IPM) type having positive saliency is employed for a positive d-axis current to mitigate a demagnetizing field in the magnet due to a q-axis current. A proof-of-principle machine is designed, fabricated and evaluated. A series of experiments are conducted to capture the efficiency contours with different magnetization states of the low coercive force magnets. The designed machine shows benefits in improving efficiency when the magnetization state is optimally operated. With these results, the loss over a driving cycle is then simulated and the benefits of changing the magnetization state are quantified.
Structural and functional thalamocortical connectivity study in female fibromyalgia (2021)

Dysfunctional thalamocortical interactions have been suggested as putative mechanisms of ineffective pain modulation and also suggested as possible pathophysiology of fibromyalgia (FM). However, it remains unclear which specific thalamocortical networks are altered and whether it is related to abnormal pain perception in people with FM. Here, we conducted combined vertex-wise subcortical shape, cortical thickness, structural covariance, and resting-state functional connectivity analyses to address these questions. FM group exhibited a regional shape deflation of the left posterior thalamus encompassing the ventral posterior lateral and pulvinar nuclei. The structural covariance analysis showed that the extent of regional deflation of the left posterior thalamus was negatively covaried with the left inferior parietal cortical thickness in the FM group, whereas those two regions were positively covaried in the healthy controls. In functional connectivity analysis with the left posterior thalamus as a seed, FM group had less connectivity with the periaqueductal gray compared with healthy controls, but enhanced connectivity between the posterior thalamus and bilateral inferior parietal regions, associated with a lower electrical pain threshold at the hand dorsum (pain-free point). Overall, our findings showed the structural thalamic alteration interacts with the cortical regions in a functionally maladaptive direction, leading the FM brain more responsive to external stimuli and potentially contributing to pain amplification.
New hybrid organic-inorganic materials based on a poly(titanium oxide) gel with efficient UV-induced separation of charges (2006)

The author's name should read Rozes rather than Rosez.2. Throughout the text ethylene glycol monomethacrylate (EGM) should instead read 2-hydroxyethyl methacrylate (HEMA).3. On p. 104 (Fig. 2b) the correct units of the x axis are Ω rather than Hz. 4. On p. 104 (right column, third row above the figure) and on p. 105 (left column, second row), the correct name of the initiator of radical polymerization is azobisisobutyronitrile (AIBN) rather than azoisobutyric acid dinitrile.
Simple salts of abundant metals (Fe, Bi, and Ti) supported on montmorillonite as efficient and recyclable catalysts for regioselective intramolecular and intermolecular hydroalkoxylation reactions of double bonds and tandem processes (2016)

Montmorillonites doped with metal cations are efficient and recyclable catalysts for hydroalkoxylation reactions and amenable to flow chemistry.
Smart Meter Privacy Control Strategy Including Energy Storage Degradation (2019)

In this paper, we present a degradation-aware privacy control strategy for smart meters by taking into account the capacity fade and energy loss of the battery, which has not been included previously. The energy management strategy is designed by minimizing the weighted sum of both privacy loss and total energy storage losses, where the weightage is set using a trade-off parameter. The privacy loss is measured in terms of Bayesian risk of an unauthorized hypothesis test. By making first-order Markov assumptions, the stochastic parameters of energy loss and capacity fade of the energy storage system are modelled using degradation maps. Using household power consumption data from the ECO dataset, the proposed control strategy is numerically evaluated for different trade-off parameters. Results show that, by including the degradation losses in the design of the privacy-enhancing control strategy, significant improvement in battery life can be achieved, in general, at the expense of some privacy loss.
Catalytic Enantioselective β‐Alkylation of α,β‐Unsaturated Aldehydes by Combination of Transition‐Metal‐ and Aminocatalysis: Total Synthesis of Bisabolane Sesquiterpenes (2011)

Branching out! The first co-catalytic enantioselective (up to 98:2 e.r.) β-alkylation of α,β-unsaturated aldehydes by combination of simple chiral amine and copper catalysts provides β-branched aldehydes in a one-pot protocol. The methodology was applied to the short total syntheses of bisabolane sesquiterpenes (S)-(+)-curcumene, (E)-(S)-(+)-3-dehydrocurcumene and (S)-(+)-tumerone.
Interaction of Ulva and Navicula Marine Algae with Surfaces of Pyridinium Polymers with Fluorinated Side-Chains (2005)

Adhesion is achieved by the secretion of a hydrophilic glycoprotein that crosslinks rapidly after release from the spore. 4 The goal of the work reported here was to investigate whether 4-vinylpyridinium polymers that formed bactericidal surfaces could also function as marine antifouling surfaces. Polystyrene-block-poly(4- vinylpyridine) (PS/P4VP) was quaternized with alkyl and fluoroalkyl bromides, and surface-activity against Ulva and Navicula was studied. The number of Ulva zoospores and Navicula cells settling and attaching to the these surfaces was determined and compared to hydrophobic poly(dimethyl siloxane) and hydrophilic glass controls. A block copolymer with fluoroalkyl side chains, but without the positive charge of the 4-vinylpyridinium polymers was also studied. The adhesion strengths of algal cells were characterized by the degree of removal under water shear stress in a turbulent flow channel.
Study of the Reflectivity of Silver Films Deposited by Radio Frequency and Direct Current Coupled Magnetron Sputtering (2011)

Silver films are deposited on a SiO 2 surface and a cyclo-olefin polymer surface by radio frequency and direct current (RF–DC) coupled magnetron sputtering to realize light reflectors with high reflectivity in the visible light region. Because the reflectivity of silver is relatively low, especially in the short-wavelength region less than 500 nm owing to a slight increase in the refractive index of silver, deposition conditions are studied with emphasis on maximizing the reflectivity in this region. Also, protection film depositions of Si 3 N 4 on a silver surface by microwave-excited-plasma-enhanced chemical vapor deposition were carried out to improve the durability of silver films, which are easily oxidized and/or sulfurized, resulting in the degradation of the reflectivity of the films. It is found that a high reflectivity in the short-wavelength region can be obtained by Xe plasma sputtering and/or Ar plasma sputtering at a relatively high working pressure, i.e., the conditions with a low ion bombardment energy at the substrate surface. At the same time, a normalized ion flux supplied to the substrate surface at approximately 2 is optimum, where the normalized ion flux is defined as the ratio of plasma-ion flux to deposited-atom flux on the growing film surface. Under such optimized deposition conditions, a silver film with a low resistivity and a smooth surface is obtained. Furthermore, it is found that a Si 3 N 4 film with a thickness of 8 nm on a silver surface serves as a good protection film without serious degradation of reflectivity, and the reflectivity can be maintained even after the immersion of the sample in the boiling water (100 °C) for 2 h.
Non-Peptidic Small-Molecule Antagonists of the Human Platelet Thrombin Receptor PAR-1 (2003)

The thrombin receptor on human platelets is the first member identified of a new family of G-protein coupled receptors referred to as protease activated receptors (PARs). These receptors are activated by a unique mechanism involving proteolytic cleavage of a portion of the extracellular domain to generate a new N-terminus which then acts as a tethered or intramolecular ligand (agonist) for the receptor. The hexapeptide SFLLRN-NH2 comprising the new N-terminus is referred to as the Thrombin Receptor Activating Peptide, or "TRAP" Thrombin is the most potent agonist for platelet aggregation and selective blockade of the intramolecular activation step without effecting the proteolytic activity of thrombin should result in moderation of platelet activation and aggregation without interfering with the other coagulation cascade effects of thrombin. Screening of combinatorial libraries identified a novel, non-peptide PAR-1 thrombin receptor antagonist. Examination of structure-activity relationships revealed that portions of the molecule could be replaced resulting in simpler molecules of lower molecular weight that were at the same time more potent. Molecules in this series were effective antagonists of TRAP-stimulated platelet activation, but had limited activity when thrombin was the agonist. Additional directed screening and subsequent lead refinement resulted in a second series of isoxazole based compounds. Some of the resultant molecules were potent PAR-1 antagonists that were effective against both TRAP- and thrombin-stimulated receptor activation. These compounds do not inhibit the proteolytic effects of thrombin but rather interfere with the intramolecular binding of the tethered ligand (SFLLRN) to the transmembrane portion of the thrombin receptor. They represent promising leads for future explorations of antithrombotic activity of thrombin receptor antagonists.
V-Y Quadricepsplasty in Total Knee Arthroplasty (1993)

The results in 14 consecutive patients (16 knees) who have had total knee arthroplasty (TKA) with a V-Y quadricepsplasty were reviewed. There were eight men and six women with an average age of 66.2 years. Nine patients (ten knees) had revision arthroplasty and five patients (six knees) had primary arthroplasty. Nine of the 14 patients were examined and evaluated in the biomechanics laboratory using the modified Cybex-II system at a mean of three years from surgery. Using the knee rating score of the Hospital for Special Surgery, there were two excellent, ten good, two fair, and two poor results. The average active range of motion was 4 degrees to 85 degrees. Biomechanical testing revealed statistically significant weakness in extension compared with the contralateral side only at test speeds of 120, 180, and 240 degrees per second in those patients who had contralateral normal knees. The affected side at other test speeds were weaker but did not reach statistically significant weakness when compared with the contralateral knee. Comparing V-Y quadricepsplasty to normal medial parapatellar TKA patients, the extensor mechanism was weaker in the V-Y group but not to a significant degree. If one requires a V-Y quadricepsplasty during TKA, one can expect near normal active extension and moderate weakness in extension. Knee scores reflect the difficult reconstructive challenges that are inherent in patients who require a V-Y quadricepsplasty.
Application Of Guided-Wave Optics In Signal Processing (1987)

Research in the use of guided wave optics for signal processing is reviewed, and advantages and limitations of the technology are discussed. The signal processors employ electrooptic and fiber optic components to perform such functions as spectral analysis of radio-frequency signals, correlation and matched filtering, code and waveform synthesis, signal delay and storage, and analog-to-digital and digital-to-analog conversion. In most cases the guided-wave approach is distinguished by the ability to perform a particular function at very high analog bandwidths or digital data rates. In concluding remarks, an effort is made to provide some perspective on competing technologies and to indicate some areas where future research might prove fruitful.
Acute Kidney Injury: Classification and Staging (2010)

It was not until recently that consensus definitions for acute kidney injury (AKI) were proposed and published. The RIFLE (Risk-Injury-Failure-Loss-End-stage renal disease) and AKIN (Acute Kidney Injury Network) classifications were designed in order to be easily understood and applied in a variety of clinical and research settings. Their creation was intended to uniformly establish the presence or absence of the AKI and to give a quantitative idea of the severity of the disease unifying the commonly used parameters of serum creatinine and urine output. Subsequent validation showed that both the presence and severity of AKI, defined using RIFLE/AKIN, correlate well with patient outcome. This review will briefly describe the RIFLE/AKIN consensus definitions, its subsequent revisions and its successful validation and application to clinical research. The potential of extending the use of RIFLE/AKIN to the clinical setting of cardiorenal syndromes is also discussed.
Lactate dehydrogenase activity staining demonstrates time-dependent immune cell infiltration in human ex-vivo burn-injured skin (2021)

Burn injuries constitute one of the most serious accidental injuries. Increased metabolic rate is a hallmark feature of burn injury. Visualising lactate dehydrogenase (LDH) activity has been previously used to identify metabolic activity differences, hence cell viability and burn depth in burn skin. LDH activity was visualised in injured and uninjured skin from 38 sub-acute burn patients. LDH activity aided the identification of spatially correlating immunocompetent cells in a sub-group of six patients. Desorption Electrospray Ionisation Mass Spectrometry Imaging (DESI MSI) was used to describe relative lactate and pyruvate abundance in burned and uninjured tissue. LDH activity was significantly increased in the middle and deep regions of burnt skin compared with superficial areas in burnt skin and uninjured tissue and positively correlated with post-burn time. Regions of increased LDH activity showed high pyruvate and low lactate abundance when examined with DESI-MSI. Areas of increased LDH activity exhibited cellular infiltration, including CD3 + and CD4 + T-lymphocytes and CD68 + macrophages. Our data demonstrate a steady increase in functional LDH activity in sub-acute burn wounds linked to cellular infiltration. The cell types associated are related to tissue restructuring and inflammation. This region in burn wounds is likely the focus of dysregulated inflammation and hypermetabolism.
<title>All-optical switching using second-order nonlinearities in KTP</title> (1994)

Photoelectron spectroscopy of coordinatively unsaturated organometallic anions can provide a means to probe the ground and low lying excited states of the corresponding neutral radicals. We report results for the early 3D transition metal monocarbonyls VCO and CrCO, and for the late metal complexes FeCO, CoCO and NiCO. Each spectrum displays a transition to the ground state of the neutral complex, and to an excited state whose spin multiplicity differs by two from that of the ground state. For a given complex, these states share nominally the same electron configuration but differ in the spin coupling of the metal 4s electron. There is a reversal in the state ordering as one proceeds across the transition series, from a high spin ground state for VCO (<SUP>6</SUP>(Sigma) <SUP>+</SUP>) and CrCO (<SUP>7</SUP>(Sigma) <SUP>+</SUP>) to a low spin ground state for FeCO (<SUP>3</SUP>(Sigma) <SUP>-</SUP>), CoCO (<SUP>2</SUP>(Delta) ) and NiCO (+1)(Sigma) )<SUP>+</SUP>). The measured state splittings and vibrational frequencies provide insight into the factors that determine the ordering and bonding properties of these states. Recent results for the linear H-M-CO isomers of Fe and Co are also reported.
Comparison of Plantar Pressure and Center of Pressure of the Normal Arch and Row Arch (2013)

Pain of flat foot patients often appears at the heel, navicular bone part, and the metatarsal bone part. The purpose of this study was to compare normal arch group and low arch group, to determine differences of the plantar pressure of medial longitudinal arch, and to track the center of foot pressure between those two groups during normal gait. The subjects were 18 healthy adults with 36 feet, and we classified 9 normal left arches of the foot, 9 low left arches of the foot, 9 normal right arches of the foot, and 9 low right arches of the foot. The left low arch group showed a significantly greater value of plantar pressure in 1st metatarsal bone, 3rd metatarsal bone, 5th metatarsal bone, arch section, lateral heels, and medial heel in comparison with left normal arch group. Right low arch group showed a significantly greater value of plantar pressure in the arch section in comparison with right normal arch group. The center of foot pressure was significantly higher than normal arch groups, and this was considered to show a relationship with pain of the flat foot. Tracking the center of foot pressure for low arch groups showed irregular waveforms medially in comparison with normal arch group. We have speculated that there is a spring function at the arch of the foot to absorb shock. The low arch foot groups could not perform the spring function under load during gait, so the centers of foot pressure were high. The most likely reason why the low arch group showed irregular and more interior waveform from the inside at the locus of the foot pressure was that absorption of the pressure was more inside due to the low medial longitudinal arch. Irregular waveform of the tracking center of foot pressure was considered to show unstable stance phase during gait.
Single Molecules, Single Nanoparticles and Their Optical Interaction (2003)

We have applied a new method to localize single dye molecules with nanometer resolution in three dimensions by means of the Stark effect. With this method we were able to resolve two molecules which were so close to each other that they underwent a strong dipole‐dipole interaction. A quantitative spectral study of this system allowed us to determine the coupling parameters. In the second part of this paper we discuss our research on metal nanoparticles. We have developed a method to mount single nanoparticles at the very end of a fibre tip. We have used such probes as well defined scattering centers for apertureless scanning near‐field optical microscopy. In this article we also discuss our efforts to examine the interaction of a single metal nanoparticle and a single molecule in a controlled manner.