gebhart/patrepeval huggingface dataset:
A 19th Century “Ideal” Oil Paint Medium: A Complex Hybrid Organic–Inorganic Gel (2017)

Abstract British 19th century painters such as J. M. W. Turner, commonly modified the properties of their paint by using gels called “gumtions”. These gels allowed them to easily tune the paint handling and drying properties. The fascinating properties of these “gumtions” were obtained by adding lead acetate to a ternary system based on mastic resin, linseed oil and turpentine. Herein, we report and investigate in depth the rheological properties of these gels as well as their structure at a molecular and supra‐molecular scale.
Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task (2002)

A number of reports have indicated that adult neurogenesis might be involved in hippocampal function. While increases in adult neurogenesis are paralleled by improvements on learning tasks and learning itself can promote the survival of newly generated neurons in the hippocampus, a causal link between learning processes and adult hippocampal neurogenesis is difficult to prove. Here, we addressed the related question of whether the baseline level of adult neurogenesis is predictive of performance on the water maze task as a test of hippocampal function. We used ten strains of recombinant inbred mice, based on C57BL/6, which are good learners and show high baseline levels of neurogenesis, and DBA/2, which are known to be poor learners and which exhibit low levels of adult neurogenesis. Two of these strains, BXD-2 and BXD-8, showed a 26-fold difference in the number of newly generated neurons per hippocampus. Over all strains, including the parental strains, there was a significant correlation between the number of new neurons generated in the dentate gyrus and parameters describing the acquisition of the water maze task (slope of the learning curves). Similar results were seen when the parental strains were not included in the analysis. There was no correlation between adult hippocampal neurogenesis and probe trial performance, performance on the rotarod, overall locomotor activity, and baseline serum corticosterone levels. This result supports the hypothesis that adult neurogenesis is involved in specific aspects of hippocampal function, particularly the acquisition of new information.
Synthesis of model compounds for coal liquefaction research. Quarterly report No. 1, June 21, 1990--September 20, 1990 (1990)

The objectives of this project are to develop feasible synthetic routes to produce (1) 4(4`-hydroxy-5`,6`,7`,8`-tetrahydro-l`-naphthylmethyl )- 6-methyldibenzothiophene, and (2) a 1-hydroxynaphthalene-benzothiophene polymer. Our experimental work during this quarter concentrated on. As several possible synthetic routes to the target molecule, 4(4`-hydroxy-5`,6`,7`,8`-tetrahydro- l`-naphthylmethyl )-6-methyldibenzothiophene. We tried synthesizing the intermediates for our first method, in which we couple a metalated 4-methyldibenzothiophene with 4-formyl-5,6,7,8-tetrahydro-1-naphthol. We found that we could easily metalate dibenzothiophene, and then add a methyl group to the 4-position to give 4-methyldibenzothiophene in greater than 80% yield by using t-butyllithium in tetrahydropyran followed by dimethylsulfate. However, adding the second metal to the desired 4` position using the same method was more difficult, and instead the reaction occurred on the methyl group. Therefore, we will investigate an alternative method, in which a hydroxy group is added in order to help direct the second metalation step to the 4` position on 4-methyldibenzothiophene.
Atomic Layer Deposition in Nanometer-Level Replication of Cellulosic Substances and Preparation of Photocatalytic TiO2/Cellulose Composites (2005)

TiO2 replicas of filter paper with nanometer-level accuracy were prepared by atomic layer deposition of thin conformal TiO2 coating, followed by a removal of the paper by air-anneal at 450 degrees C. Photocatalytic anatase TiO2/cellulose composites were also made by leaving the paper intact. The TiO2 films were deposited from Ti(OMe)4 and H2O at 150-250 degrees C. The photocatalytic activity of the TiO2/cellulose composite was verified by photocatalytic reduction of Ag(I) from an aqueous solution to Ag nanoparticles on the TiO2 surface. The TiO2/cellulose composites are mechanically more stable than the free-standing TiO2 replicas and are therefore potentially suitable as lightweight, high surface area photocatalysts.
Motion of Surface Atoms on Small Gold Particles Revealed by HREM with Real-Time VTR System (1985)

A new method of high resolution electron microscopy utilizing a real time VTR-TV monitor system has been developed for the study of small metal particles less than 100 Å in size. The study for the first time revealed the real time motion of the surface atoms on a 100 Å gold cluster. The particle is a cuboctahedron and its {111} and {100} type surface are viewed as their edge-on projections along the &lt;110 &gt; direction. The surface atomic steps are formed on the {100} type surfaces but not on the {111} surfaces. The steps frequently change their positions within less than one tenth of a second. This motion is direct evidence of the random walk of the surface atoms on metal surfaces.
Three-dimensional optical data storage using third-harmonic generation in silver zinc phosphate glass (2008)

We demonstrate the possibility of three-dimensional optical data storage inside a specific zinc phosphate glass containing silver by using third-harmonic generation (THG) imaging. Information is stored inside the glass with femtosecond laser irradiation below the refractive index modification threshold. We use the same laser for THG readout. The capability of storage with this technique is discussed.
Solid-source doping by using phosphosilicate glass into p-type bulk Si (100) substrate: Role of the capping SiO2 barrier (2018)

Systematic experimental studies on phosphorus diffusion from phosphosilicate glass into the p-type bulk Si (100) substrate with different capping barrier layer thicknesses have been conducted. In both 2- and 5-nm phosphosilicate glass conditions, a thicker SiO2 cap showed a lower sheet resistance and a higher retained phosphorus dose in the Si substrate after 1050 °C 4 s rapid thermal annealing as drive-in annealing. However, the sheet resistance of 2-nm phosphosilicate glass with a 10-nm SiO2 cap was lower than that of 5-nm phosphosilicate glass with a 3-nm SiO2 cap due to a higher retained phosphorus dose in the Si substrate. For a higher retained phosphorus dose in the Si substrate using fixed total thickness, 2-nm phosphosilicate glass with 6-nm SiO2 cap is better than 5-nm phosphosilicate glass with 3-nm SiO2 cap since prevention of phosphorus out-diffusion during the drive-in annealing is more important than the total phosphorus dose in phosphosilicate glass. Next, SiO2 cap thickness on 2-nm phosphosilicate glass was split to understand the role of the SiO2 capping layer in detail for scaled devices. 3-nm SiO2 cap could not prevent out-diffusion during the drive-in annealing, and it showed much higher sheet resistance and lower retained phosphorus dose in the Si substrate. The highest retained phosphorus dose in the Si substrate was observed for 6-nm SiO2 cap and resulted in 1.8 × 1014 atoms/cm2 retained phosphorus dose with 96% activation level after 1050 °C 4 s rapid thermal annealing. Thicker SiO2 caps than 6 nm were not beneficial since 10-nm SiO2 cap showed a higher sheet resistance value as well as lower phosphorus activation level (82%) compared to 6-nm SiO2 cap even though both the process conditions showed same phosphorus profiles after the drive-in annealing. That sheet resistance increase with 10-nm SiO2 cap could be caused by heterogeneous surface formation on the Si substrate with a prolonged SiO2 atomic layer deposition process.
Evidence for delta receptor mediation of [D-Pen2,D-Pen5]-enkephalin (DPDPE) analgesia in mice. (1986)

Possible involvement of cerebral delta opioid receptors in antinociceptive processes was studied in a test utilizing heat as the noxious thermal stimulus. The investigation focused on selective agonists and antagonists for mu and delta opioid receptors. Morphine and [D-Ala2,NMPhe4, Gly-ol]enkephalin (DAGO) were used as agonists for the mu receptor while [D-Pen2,D-Pen5]enkephalin (DPDPE) was the agonist for the delta receptor. Two approaches were employed: first, the intracerebroventricular (i.c.v.) analgesic activity of the agonists was determined in the absence, and in the presence of graded i.c.v. doses of the selective delta antagonist, ICI 174,864 (N,N diallyl-Tyr-Aib-Aib-Phe-Leu-OH) (where Aib is alpha-aminoisobutyric acid); second, acute tolerance to morphine was produced and the possible presence of acute cross-tolerance between subcutaneous (s.c.) morphine and the delta agonist investigated. ICI 174,864 antagonized the analgesia produced by DPDPE, but not that resulting from morphine or DAGO. Morphine pretreatment resulted in the development of acute tolerance to i.c.v. morphine, and acute cross-tolerance to i.c.v. DAGO, but not to i.c.v. DPDPE. These results provide evidence that both cerebral delta and mu opioid receptors are responsible for the mediation of analgesia in tests utilizing heat as the nociceptive stimulus.
Missense variant contribution to USP9X-female syndrome (2020)

USP9X is an X-chromosome gene that escapes X-inactivation. Loss or compromised function of USP9X leads to neurodevelopmental disorders in males and females. While males are impacted primarily by hemizygous partial loss-of-function missense variants, in females de novo heterozygous complete loss-of-function mutations predominate, and give rise to the clinically recognisable USP9X-female syndrome. Here we provide evidence of the contribution of USP9X missense and small in-frame deletion variants in USP9X-female syndrome also. We scrutinise the pathogenicity of eleven such variants, ten of which were novel. Combined application of variant prediction algorithms, protein structure modelling, and assessment under clinically relevant guidelines universally support their pathogenicity. The core phenotype of this cohort overlapped with previous descriptions of USP9X-female syndrome, but exposed heightened variability. Aggregate phenotypic information of 35 currently known females with predicted pathogenic variation in USP9X reaffirms the clinically recognisable USP9X-female syndrome, and highlights major differences when compared to USP9X-male associated neurodevelopmental disorders.
Constant Temperature Artificial Incubation of Spawned Eggs in Natural Nests from the Chinese Freshwater Soft-Shelled Turtle, Tryonyx sinensis Strauch(1862) (2017)

On June 14, 2008 (the first experiment) and July 24, 2008 (the second experiment), the shores of the Boseong River and the sandy beaches, Seokgok-myun, Moksadong-myun, Gokseong-gun in Jeollanam Province were investigated and a total of 29 soft-shelled turtle (<i>Tryonyx sinensis</i>) eggs in the natural spawning nest eggs were collected (13 eggs were collected in the first experiment and 16 eggs in the second experiment). The temperatures in the natural spawning nests were 25.9-36.9±0.5℃, the depth of the eggs was 5.2-7.5±0.5 cm as the distance of the average 6.4±0.5 cm. 29 eggs were scattered at least 0.2 cm interval. Artificial incubation of 29 eggs was conducted in artificial nest boxes in thermo-plastic composition of the incubator, and then incubated at 26.5-35.5±0.5℃, and an average constant temperature was 31.2-32.1±1.0℃. The incubation days ranged from 53 to 55. In case of most turtles, incubation at 31℃ (higher temperatures) generally produces all or mostly females, while incubation at 25℃(cooler temperatures) produces all or mostly males. Exceptionally, in case of genus <i>Trionyx,</i> the sex ratio of female : male of <i>T. sinensis</i> of a freshwater soft-shelled turtle was approximately 1:1, which differs from other genera of turtles and makes <i>T. sinensis</i> Strauch only turtles presently known to lack temperature-dependent sex determination.
A SQUID System for Measurement of Spinal Cord Evoked Field of Supine Subjects (2009)

An LTS SQUID biomagnetometer system was developed for the non-invasive diagnosis method of the spinal cord function for orthopedic and neurologic application. The developed biomagnetometer system is characterized by a uniquely shaped cryostat. It has a vertical cylinder-shaped main body and a protrusion from its side surface. An array of SQUID vector gradiometers with a 5 times 8 matrix-like arrangement for 90 mm times 140 mm observation area is installed in the protrusion. Supine subjects are able to fit their cervixes stably to the sensor array by putting them against the protrusion during the measurement. The sensors directed vertically upwards detect magnetic signals from the back of the cervix. An X-ray imaging apparatus is integrated to the SQUID system for the in-situ acquisition of the anatomical information that reveals the position of cervical vertebrae relative to the location of the sensor array. For the performance verification of the developed system, we examined the spinal cord evoked field measurement of a normal subject. We succeeded in observing the transition of the cervical magnetic field distribution induced by the electric pulse stimulation on the median nerve at the subject's wrist.
Josephson junction microwave amplifier in self-organized noise compression mode (2014)

The fundamental noise limit of a phase-preserving amplifier at frequency $ω/2π$ is the standard quantum limit $T_{q}=\hbar ω/2k_{B}$. In the microwave range, the best candidates have been amplifiers based on superconducting quantum interference devices (reaching the noise temperature $T_{n} \sim 1.8 T_{q}$ at 700 MHz), and non-degenerate parametric amplifiers (reaching noise levels close to the quantum limit $T_{n}\approx T_{q}$ at 8 GHz). We introduce a new type of an amplifier based on the negative resistance of a selectively damped Josephson junction. Noise performance of our amplifier is limited by mixing of quantum noise from Josephson oscillation regime down to the signal frequency. Measurements yield nearly quantum-limited operation, $T_{n}=(3.2\pm 1.0) T_{q}$ at 2.8 GHz, owing to self-organization of the working point. Simulations describe the characteristics of our device well and indicate potential for wide bandwidth operation.
Multi‐mode dual‐polarised cavity backed patch antenna array for 5G mobile devices (2021)

Abstract This paper proposes a dual‐polarised cavity backed patch antenna for next generation phased arrays for mobile handsets. The antenna exhibits multi‐band performance, allowing to cover the 5G bands n257 (26.5–29.5 GHz), n258 (24.25–27.5 GHz), n261 (27.5–28.35 GHz) and a portion of band n260 (37–40 GHz). Two orthogonal modes are excited in the substrate integrated waveguide (SIW) cavity and show similar impedance matching and symmetric radiation patterns. A parasitic element is introduced on top of the cavity and shifted off‐centre to improve the port‐to‐port isolation and guide the main beam. A parametric study of the antenna dimensions is conducted to verify the multi‐resonance operating mechanism. The design is validated by the measurements of the fabricated four‐element array. The array scanning angle is from −35° to 38° for V‐pol and from −29° to 31° for H‐pol at 28 GHz, where the realised gain raises from 8 to 12 dBi.
A Scalable and Highly Available System for Serving Dynamic Data at Frequently Accessed Web Sites (1998)

This paper describes the system and key techniques used for achieving performance and high availability at the official Web site for the 1998 Olympic Winter Games which was one of the most popular Web sites for the duration of the Olympic Games. The Web site utilized thirteen SP2 systems scattered around the globe containing a total of 143 processors. A key feature of the Web site was that the data being presented to clients was constantly changing. Whenever new results were entered into the system, updated Web pages reflecting the changes were made available to the rest of the world within seconds. One technique we used to serve dynamic data efficiently to clients was to cache dynamic pages so that they only had to be generated once. We developed and implemented a new algorithm we call Data Update Propagation (DUP) which identifies the cached pages that have become stale as a result of changes to underlying data on which the cached pages depend, such as databases. For the Olympic Games Web site, we were able to update stale pages directly in the cache which obviated the need to invalidate them. This allowed us to achieve cache hit rates of close to 100%. Our system was able to serve pages to clients quickly during the entire Olympic Games even during peak periods. In addition, the site was available 100% of the time. We describe the keyfeatures employed by our site for high availability. We also describe how the Web site was structured to provide useful information while requiring clients to examine only a small number of pages.
Electrokinetic Effect of Builder on Washing Process (1987)

The relation between the electrokinetic effects of a builder and detergency is discussed in terms of the ζ-potential and potential energy of interaction. Detergency and redeposition with various builders were measured. The ζ-potentials of carbon black, clay and cellulose in each solution containing various builders were measured. Potential energies due to interactions between the soil and fabrics were calculated according to the heterocoagulation theory. The results indicated that : 1) a builder increases the ζ-potential of soils; 2) the minimum potential energy is more closely related to detergency than any other potential energy.
Transfusion support for matched sibling allogeneic hematopoietic stem cell transplantation (1993–2010): factors that predict intensity and time to transfusion independence (2018)

Patient-specific factors including CD34+ dose and ABO match of the graft should be given particular consideration by transfusion services when planning support of patients receiving allogeneic hematopoietic stem cell transplant.
Performance of turbo frequency domain equalizer using iterative decision-directed channel estimation for DFT-precoded OFDMA (2013)

This paper proposes iterative decision-directed channel estimation (IDDCE) associated with the turbo frequency domain equalizer (FDE) for discrete Fourier transform (DFT)-precoded Orthogonal Frequency Division Multiple Access (OFDMA). By using soft-symbol estimations based on the extrinsic log-likelihood ratio (LLR) at the Max-Log-MAP decoder output and for the reference signal (RS), the accuracy of the channel response is improved in the iterative inner loop employing the feed-forward (FF)-FDE at an iteration of the outer loop for the turbo FDE. Computer simulation results show that the improvement in the required average received signal-to-noise power ratio (SNR) that satisfies the target average block error rate (BLER) is saturated with two iterations for both inner and outer loops regardless of the modulation scheme. We also show that IDDCE using the FF-FDE based on the Minimum Mean-Square Error (MMSE) criterion at an iteration of the turbo FDE is effective in improving the average BLER of the turbo FDE.
Self-Immolative Thiocarbamates Provide Access to Triggered H2S Donors and Analyte Replacement Fluorescent Probes (2016)

Hydrogen sulfide (H2S) is an important biological signaling molecule, and chemical tools for H2S delivery and detection have emerged as important investigative methods. Key challenges in these fields include developing donors that are triggered to release H2S in response to stimuli and developing probes that do not irreversibly consume H2S. Here we report a new strategy for H2S donation based on self-immolation of benzyl thiocarbamates to release carbonyl sulfide, which is rapidly converted to H2S by carbonic anhydrase. We leverage this chemistry to develop easily modifiable donors that can be triggered to release H2S. We also demonstrate that this approach can be coupled with common H2S-sensing motifs to generate scaffolds which, upon reaction with H2S, generate a fluorescence response and also release caged H2S, thus addressing challenges of analyte homeostasis in reaction-based probes.
High-Density Disc Mastering with Nano-Patterned Pits by an Artificially Assisted Self-Assembling Method (2003)

A new process for creating high-density disc mastering has been proposed. Ni stampers with smaller pits than conventional mastering and nano-replication were confirmed. A pit size has been reduced by 15nm on a Ni stamper. Full text article is not available.
Irbesartan promotes erection recovery after nerve‐sparing radical retropubic prostatectomy: a retrospective long‐term analysis (2012)

• Regular irbesartan use after nerve-sparing RRP in patients with normal preoperative erectile function could improve EF recovery after surgery and mitigate early loss of SPL.
Levocetirizine and montelukast in the COVID-19 treatment paradigm (2021)

Levocetirizine, a third-generation antihistamine, and montelukast, a leukotriene receptor antagonist, exhibit remarkable synergistic anti-inflammatory activity across a spectrum of signaling proteins, cell adhesion molecules, and leukocytes. By targeting cellular protein activity, they are uniquely positioned to treat the symptoms of COVID-19. Clinical data to date with an associated six-month follow-up, suggests the combination therapy may prevent the progression of the disease from mild to moderate to severe, as well as prevent/treat many of the aspects of 'Long COVID,' thereby cost effectively reducing both morbidity and mortality. To investigate patient outcomes, 53 consecutive COVID-19 test (+) cases (ages 3-90) from a well-established, single-center practice in Boston, Massachusetts, between March - November 2020, were treated with levocetirizine and montelukast in addition to then existing protocols [2]. The data set was retrospectively reviewed. Thirty-four cases were considered mild (64%), 17 moderate (32%), and 2 (4%) severe. Several patients presented with significant comorbidities (obesity: n = 22, 41%; diabetes: n = 10, 19%; hypertension: n = 24, 45%). Among the cohort there were no exclusions, no intubations, and no deaths. The pilot study in Massachusetts encompassed the first COVID-19 wave which peaked on April 23, 2020 as well as the ascending portion of the second wave in the fall. During this period the average weekly COVID-19 case mortality rate (confirmed deaths/confirmed cases) varied considerably between 1 and 7.5% [37]. FDA has approved a multicenter, randomized, placebo-controlled, Phase 2 clinical trial design, replete with electronic diaries and laboratory metrics to explore scientific questions not addressed herein.
Novel 3‐Phenylprop‐2‐ynylamines as Inhibitors of Mammalian Squalene Epoxidase. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Comparison of symmetric and asymmetric bipolar type high triplet energy host materials for deep blue phosphorescent organic light-emitting diodes (2012)

Symmetric and asymmetric bipolar host materials for deep blue phosphorescent organic light-emitting diodes were developed and the chemical structure of the host materials was correlated with the device performances. The bipolar host with the asymmetric molecular structure was better than the host with symmetric molecular structure in terms of driving voltage and quantum efficiency due to better charge transport properties. A high quantum efficiency of 24.5% and a high power efficiency of 31.0 lm W−1 were achieved in the deep blue device using the asymmetric bipolar host due to balanced charge transport and low driving voltage.