gebhart/patrepeval huggingface dataset:
Enzymic synthesis of uridine 5'-diphosphoglucuronic acid on a gram scale (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzymic synthesis of uridine 5'-diphosphoglucuronic acid on a gram scaleEric J. Toone, Ethan S. Simon, and George M. WhitesidesCite this: J. Org. Chem. 1991, 56, 19, 5603–5606Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/jo00019a026https://doi.org/10.1021/jo00019a026research-articleACS PublicationsRequest reuse permissionsArticle Views248Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Smart walkers!: enhancing the mobility of the elderly (2011)

The idea of Smart Walkers is to equip customary rolling walkers with sensors in order to assist users, caregivers and clinicians. The integral part of the Smart Walkers is an autonomous agent which monitors the activity of the user, assesses his physical conditions, and detects potential risks of falls. In this paper, we study methods which enable the agent to recognize the user activity from the sensor measurements. The proposed methods use Conditional Random Fields with features based on discriminant rules. A special case are features which, in order to distinguish between two activities, compare the sensor measurements to thresholds learned by a linear classifier. Experiments with real user data show that the methods achieve a good accuracy; the best results are obtained using smooth thresholds based on sigmoid functions.
Synthesis, Characterization, and Optical Properties of New Two-Photon-Absorbing Fluorene Derivatives (2004)

The synthesis of a series of four new compounds containing fluorenyl chromophores is presented, along with the results of spectroscopic and photochemical studies aimed at understanding the two-photon absorption properties and energetics of their electronically excited states. The molecular structures of the compounds were systematically varied to allow comparison of molecules possessing high and low molecular symmetry, short and long alkyl chains, and a fluorenyl conjugated π-system. Solvent-dependent absorption and emission were investigated along with π-conjugation length. Preliminary measurements of two-photon absorption (2PA) using a two-photon fluorescence method indicate that these chromophores exhibit high two-photon absorptivity. A symmetrical molecule (3), possessing a relatively large π-conjugated system, flanked on either side by electron-withdrawing groups (benzothiazole), exhibited a peak 2PA cross section (δ) of 6000 × 10-50 cm4 s photon-1 molecule-1 at 600 nm. Excitation anisotropy studies revealed the position of the S0 → S1 and S0 → S2 electronic transitions. Consistent with quantum mechanical selection rules, the two-photon allowed transition (S0 → S2) was dominant.
Blind Source Separation using mixtures scatter plot properties (2009)

The scatter plot of two image mixtures, generated by mixing two positive sources, is bounded by a parallelogram, the orientations of which are defined by the two ratios of the four mixing coefficients. The existence of inter-source dependencies creates a distribution bounded by a different rectilinear shape, bounded by the original parallelogram. Based on this observations a robust graphical method for blind source separation (BSS) is presented with reference to the scatter plot of the mixtures. The error analysis in presence of inter source dependencies is presented.
Covalent adaptor synNotch and chimeric antigen receptors (CARs) for programmable antigen targeting (2019)

Abstract Chimeric antigen receptors (CARs) are artificial T cell receptors that re-target patients’ T cells to specifically bind and kill tumor cells. Adoptive cell therapy with CAR T cells targeting CD19 has revolutionized treatment of refractory B cell acute lymphoblastic leukemia, and there is great interest in generating CAR T cells treating other cancers by targeting additional tumor antigens. Another promising class of engineered receptors are synthetic Notch (synNotch) receptors that can sense an antigen of interest on a neighboring cell and turn on expression of any transgene(s) of interest. To expand the targeting capabilities of these receptors, we have developed “universal” CAR and SynNotch receptors whose antigen-specificity can be re-directed by co-administered tumor-specific antibodies. Instead of directly targeting a tumor antigen, our universal receptors contain the SNAPtag self-labeling enzyme, which reacts with antibodies conjugated to benzylguanine (BG) to post-translationally assemble complete covalently associated antigen receptors. We demonstrate that the activation of SNAP CAR and SNAP-SynNotch receptors can be successfully re-targeted by several clinically relevant antibodies including: Rituximab, FMC63, Herceptin, and Cetuximab. SNAP-SynNotch cells demonstrate potent transgene activation, and SNAP-CAR T cells are capable of performing effector functions in a BG-antibody-directed antigen-specific manner. Additionally, the receptor response is titratable by BG-antibody dose. Finally, a continuous mathematical model was constructed to describe and optimize system activity. SNAP synNotch and SNAP CAR T cells provide a powerful new strategy to retarget engineered cells to multiple antigens.
Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2 (2013)

How single-chain urokinase (ScuPA) mediates angiogenesis is incompletely understood. ScuPA (≥4 nM) induces phosphorylated (p)ERK1/2 (MAPK44 and MAPK42) and pAkt (Ser(473)) in umbilical vein and dermal microvascular endothelial cells. Activation of pERK1/2 by ScuPA is blocked by PD-98059 or U-0126, and pAkt (Ser(473)) activation is inhibited by wortmannin or LY-294002. ScuPA (32 nM) or protease-inhibited two-chain urokinase stimulates pERK1/2 to the same extent, indicating that signaling is not dependent on enzymatic activity. ScuPA induces pERK1/2, but not pAkt (Ser(473)), in SIN1(-/-) cells, indicating that the two pathways are not identical. Peptides from domain 2 of the urokinase plasminogen activator receptor (uPAR) or domain 5 of high-molecular-weight kininogen compete with ScuPA for the induction of pERK1/2 and pAkt (Ser(473)). A peptide of the integrin-binding site on uPAR, a β1-integrin peptide that binds uPAR, antibody 6S6 to β1-integrin, tyrosine kinase inhibitors AG-1478 or PP3, and small interfering RNA knockdown of VEFG receptor 2, but not HER1-HER4, blocked ScuPA-induced pERK1/2 and pAkt (Ser(473)). ScuPA-induced endothelial cell proliferation was blocked by inhibitors of pERK1/2 and pAkt (Ser(473)), antibody 6S6, and uPAR or kininogen peptides. ScuPA initiated aortic sprouts and Matrigel plug angiogenesis in normal, but not uPAR-deficient, mouse aortae or mice, respectively, but these were blocked by PD-98059, LY-294002, AG-1478, or cleaved high-molecular-weight kininogen. In summary, this investigation indicates a novel, a nonproteolytic signaling pathway initiated by zymogen ScuPA and mediated by domain 2 of uPAR, β1-integrins, and VEGF receptor 2 leading to angiogenesis. Kininogens or peptides from it downregulate this pathway.
Modelling, simulation and optimization for a SThm nanoprobe (2014)

This paper presents modelling, simulation and optimization results for a novel SThm probe. The model takes into account thermo-electro-mechanical equations. Moreover, a tip-surface contact model derived by taking into account microscopic multi-asperity contact is proposed and discussed. Results of multi-objective optimization are reported, and finally a multi-scale model that should reduce the simulation time is stated.
Chemically Evolved Composite Lithium-Ion Conductors with Lithium Thiophosphates and Nickel Sulfides (2017)

The development and application of all-solid-state batteries with a fast lithium-ionic conductor are hampered by structural instability and rigid stoichiometry restrictions. Here, we present a family of lithium thiophosphate prototypes with a novel principle, controlling sulfur deficiencies with the addition of nickel sulfide-based additives, for fast lithium-ion conduction and distinct electrochemical stability under the extended material constituent. Well-controlled sulfur deficiency of the Li3PS4 framework accompanied by nickel sulfide additive offers the notable increase of lithium-ion conductivity (2 × 10–3 S cm–1 at 25 °C) and high electrochemical stability (up to 10 V vs Li/Li+) in a wide composition range. We further confirm the potential application of our fast composite lithium-ion conductor as an electrolyte for the all-solid-state battery with 117 mAh g–1 capacity delivery and stable cycle life.
Electronic structures of some antimicrobial N-chloramines. Possible existence of intramolecular hydrogen bonding and its effect on germicidal efficiency (1978)

The photoelectron spectra of eight N-chloramines and N,N-dichloramines derived from either alpha-aminoisobutyric acid or 2-amino-2-methylpropanol have been measured. The lone-pair ionization potentials obtained from the photoelectron spectra have been interpreted to indicate that a substantial intramolecular interaction exists between tne N-H function and the various oxygen lone pairs of the N-chloramines. Such an intramolecular interaction for the N-chloramines can explain at least in part why these molecules are less potent as antimicrobial agents than are the N,N-cichloramine analogues for which a similar intramolecular interaction is impossible.
Intelligent Reflecting Surface-Aided SWIPT: Joint Waveform, Active and Passive Beamforming Design. (2020)

The performance of Simultaneous Wireless Information and Power Transfer (SWIPT) is severely restricted by the strength of the received Radio-Frequency (RF) signal. To tackle this problem, we introduce a low-power Intelligent Reflecting Surface (IRS) that compensates the propagation loss and boosts the transmission efficiency by a passive beamforming gain. This paper investigates an efficient IRS-aided SWIPT architecture where a multi-carrier multi-antenna Access Point (AP) transmits information and power simultaneously to a single-antenna user under the assist of an IRS. Considering energy harvester nonlinearity, we aim to maximize the Rate-Energy (R-E) tradeoff through a joint optimization of the transmit waveform and active beamforming at the AP, the reflection coefficients at the IRS, and the power splitting ratio at the user. Stationary solutions are achieved by the Alternating Optimization (AO) technique, where the optimal active beamforming is obtained in closed form, the passive beamforming is optimized by the Successive Convex Approximation (SCA) technique, and the waveform and splitting ratio are optimized by the Geometric Programming (GP) technique. Although practical IRS is limited to Frequency-Flat (FF) reflection, results demonstrate significant benefits of the proposed architecture based on a joint waveform and beamforming design to enlarge the R-E region of IRS-aided SWIPT.
Low power and high performance design challenges in future technologies (2000)

We discuss key barriers to continued scaling of supply voltage and technology for microprocessors to achieve low-power and high-performance. In particular, we focus on short-channel effects, device parameter variations, excessive subthreshold and gate oxide leakage, as the main obstacles dictated by fundamental device physics. Functionality of special circuits in the presence of high leakage, SRAM cell stability, bit line delay scaling, and power consumption in clocks & interconnects, will be the primary design challenges in the future. Soft error rate control and power delivery pose additional challenges. All of these problems are further compounded by the rapidly escalating complexity of microprocessor designs. The excessive leakage problem is particularly severe for battery-operated, high-performance microprocessors.
Simple structural quasi-optical circulator composed of tapering and bending waveguides (2000)

An optical circulator function has been realized without using any magnetooptic effect by placing a multimode tapered bending waveguide made of passive material in rotational symmetry. The higher-order propagating mode components selectively radiate from a bend of a certain curvature, and the lower-order mode components pass through the bend and radiate from the tip of the taper. When the lower-order modes are launched into the waveguide, light radiates from the tip, and couples to the propagating higher-order modes of the next waveguide at its bending section. This phenomenon is accompanied by a change in the transmission mode distribution and an excess loss of at least 3 dB. However, if the evaluation is only by the transmitted power, the device exhibits the circulator function. This small and low-cost optical device is effective in a low-speed and short-distance bidirectional data communication system. In this paper, in order to confirm the basic principles, microwave simulation was carried out to examine in detail the radiation characteristics from the tapered bending waveguide with a resolution of one wavelength. An extinction ratio of more than 18 dB was realized when the distance between the adjoining waveguides was about one wavelength. © 2000 Scripta Technica, Electron Comm Jpn Pt 2, 83(7): 31–40, 2000
The Association in Elderly Hospitalized Patients, Between Psychotropic Drugs and Hip Fractures Resulting from Falls (2015)

The rate of psychotropic drug use in general and their anticholinergic burden are similar in acutely admitted elderly patients with or without hip fractures. However, higher usage rate of anxiolytics found in the patients with hip fractures may indicate that this is a risk factor for hip fractures related to falls in elderly patients living in the community.
ChemInform Abstract: Development of the Biocatalytic Resolution of 2‐Azabicyclo(2.2.1)hept‐ 5‐en‐3‐one as an Entry to Single‐Enantiomer Carbocyclic Nucleosides. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Collecting EUV mask images through focus by wavelength tuning (2009)

Using an extreme-ultraviolet (EUV) microscope to produce high-quality images of EUV reticles, we have developed a new wavelength tuning method to acquire through-focus data series with a higher level of stability and repeatability than was previously possible. We utilize the chromatic focal-length dependence of a diffractive Fresnel zoneplate objective lens, and while holding the mask sample mechanically still, we tune the wavelength through a narrow range, in small steps. In this paper, we demonstrate the method and discuss the the relative advantages that this data collection technique affords.
A review of silicon-based wafer bonding processes, an approach to realize the monolithic integration of Si-CMOS and III–V-on-Si wafers (2021)

Abstract The heterogeneous integration of III–V devices with Si-CMOS on a common Si platform has shown great promise in the new generations of electrical and optical systems for novel applications, such as HEMT or LED with integrated control circuitry. For heterogeneous integration, direct wafer bonding (DWB) techniques can overcome the materials and thermal mismatch issues by directly bonding dissimilar materials systems and device structures together. In addition, DWB can perform at wafer-level, which eases the requirements for integration alignment and increases the scalability for volume production. In this paper, a brief review of the different bonding technologies is discussed. After that, three main DWB techniques of single-, double- and multi-bonding are presented with the demonstrations of various heterogeneous integration applications. Meanwhile, the integration challenges, such as micro-defects, surface roughness and bonding yield are discussed in detail.
Functional Proteomic and Structural Insights into Molecular Recognition in the Nitrilase Family Enzymes (2008)

Nitrilases are a large and diverse family of nonpeptidic C-N hydrolases. The mammalian genome encodes eight nitrilase enzymes, several of which remain poorly characterized. Prominent among these are nitrilase-1 (Nit1) and nitrilase-2 (Nit2), which, despite having been shown to exert effects on cell growth and possibly serving as tumor suppressor genes, are without known substrates or selective inhibitors. In previous studies, we identified several nitrilases, including Nit1 and Nit2, as targets for dipeptide-chloroacetamide activity-based proteomics probes. Here, we have used these probes, in combination with high-resolution crystallography and molecular modeling, to systematically map the active site of Nit2 and identify residues involved in molecular recognition. We report the 1.4 A crystal structure of mouse Nit2 and use this structure to identify residues that discriminate probe labeling between the Nit1 and Nit2 enzymes. Interestingly, some of these residues are conserved across all vertebrate Nit2 enzymes and, conversely, not found in any vertebrate Nit1 enzymes, suggesting that they are key discriminators of molecular recognition between these otherwise highly homologous enzymes. Our findings thus point to a limited set of active site residues that establish distinct patterns of molecular recognition among nitrilases and provide chemical probes to selectively perturb the function of these enzymes in biological systems.
Effect of glucose/sulfonylurea interaction on release of insulin, glucagon, and somatostatin from isolated perfused rat pancreas. (1979)

The effect of a sulfonylurea, glibenclamide, on the release of insulin, glucagon, and somatostatin was studied in the isolated perfused rat pancreas. At glucose concentrations of 1.1 mM or less, the drug stimulated somatostatin release, whereas glucagon release, after 2-3 min of increase, was markedly inhibited. Insulin release was moderately stimulated, and maximal release occurred relatively late. A moderate glucose load (6.7 mM) inhibited glibenclamide-induced release of somatostatin, whereas the two in combination exerted an additive action on insulin release. Greater glucose loads, which by themselves would stimulate somatostatin release, only marginally suppressed glibenclamide-induced somatostatin release. The insulinogenic effect of these glucose levels was not modified by glibenclamide. Glibenclamide may thus stimulate both the alpha and beta as well as delta cells of the pancreas, depending on glucose concentration. We suggest a paracrine (local) interaction of somatostatin with the alpha and beta cells, which has an important role in the kinetics of insulin and glucagon release induced by sulfonylureas.
CTLA-4 ligation suppresses CD28-induced NF-κB and AP-1 activity in mouse T cell blasts. (1999)

Dr. Riesbeck's name was spelled incorrectly. The correct spelling is shown above.
Guinea pig lymphotoxin (LT). II. Physicochemical properties of LT produced by lymphocytes stimulated with antigen or concanavalin A: its differentiation from migration-inhibitory factor (MIF). (1973)

Guinea pig lymphotoxin (LT) produced by stimulation of sensitized lymph node cells, specifically by antigen or non-specifically by concanavalin A, was studied by methods previously used to characterize guinea pig migration-inhibitory factor. The results showed that LT induced by either antigen or mitogen was heat labile, eluted from Sephadex columns with peak activity in fractions containing molecules of 35,000 to 55,000 m.w., had an electrophoretic mobility at pH 9.1 similar to albumin and a buoyant density on CsCl similar to protein. It was destroyed by chymotrypsin but not by neuraminidase. These studies show that guinea pig LT can be readily differentiated from guinea pig migration-inhibitory factor. On the other hand, the LT produced by antigen stimulation has many features in common with LT produced by stimulation with concanavalin A.
Linear Predictive Approaches Separate Field Potentials in Animal Model of Parkinson's Disease (2020)

Parkinson's disease (PD) causes impaired movement and cognition. PD can involve profound changes in cortical and subcortical brain activity as measured by electroencephalography or intracranial recordings of local field potentials (LFP). Such signals can adaptively guide deep-brain stimulation (DBS) as part of PD therapy. However, adaptive DBS requires the identification of triggers of neuronal activity dependent on real time monitoring and analysis. Current methods do not always identify PD-related signals and can entail delays. We test an alternative approach based on linear predictive coding (LPC), which fits autoregressive (AR) models to time-series data. Parameters of these AR models can be calculated by fast algorithms in real time. We compare LFPs from the striatum in an animal model of PD with dopamine depletion in the absence and presence of the dopamine precursor levodopa, which is used to treat motor symptoms of PD. We show that in dopamine-depleted mice a first order AR model characterized by a single LPC parameter obtained by LFP sampling at 1 kHz for just 1 min can distinguish between levodopa-treated and saline-treated mice and outperform current methods. This suggests that LPC may be useful in online analysis of neuronal signals to guide DBS in real time and could contribute to DBS-based treatment of PD.
Mismatch Responses to Pitch Changes in Early Infancy (2007)

We investigated the emergence of discriminative responses to pitch by recording 2-, 3-, and 4-month-old infants' electro-encephalogram responses to infrequent pitch changes in piano tones. In all age groups, infants' responses to deviant tones were significantly different from responses to standard tones. However, two types of mismatch responses were observed simultaneously in the difference waves. An increase in the left-lateralized positive slow wave was prominent in 2-month-olds, present in 3-month-olds, but insignificant in 4-month-olds. A faster adultlike mismatch negativity (MMN), lateralized to the right hemisphere, emerged at 2 months of age and became earlier and stronger as age increased. The coexistence and dissociation of two types of mismatch responses suggests different underlying neuromechanisms for the two responses. Furthermore, the earlier emergence of the MMN-like component to changes in pitch compared to other sound features implies that neural circuits involved in generating MMN-like responses have different maturational timetables for different sound features.
Supplementary Table S3 from Cyst Fluid Telomerase Activity Predicts the Histologic Grade of Cystic Neoplasms of the Pancreas (2023)

&lt;p&gt;Supplementary Table S3; Diagnostic performance of telomerase activity comparing to the multiple imaging and clinical factors among 84 cases without prior thawing in the discovery set.&lt;/p&gt;