gebhart/patrepeval huggingface dataset:
Current concepts for aligning knee implants: patient-specific or systematic? (2018)

Mechanical or anatomical alignment techniques create a supposedly 'biomechanically friendly' but often functionally limited prosthetic knee.Alternative techniques for alignment in total knee arthroplasty (TKA) aim at being more anatomical and patient-specific, aiming to improve functional outcomes after TKA.The kinematic alignment (KA) technique for TKA has shown good early clinical outcomes. Its role in extreme anatomical variation remains to be defined.The restricted KA technique for TKA might be a reasonable option for patients with extreme anatomical variation.While unicompartmental knee arthroplasty (UKA) has many advantages over TKA, the revision rate remains higher compared with TKA. One major explanation is the relative ease with which a UKA can be converted to a TKA, compared with revising a TKA. This can be considered as an additional advantage of UKA. Another reason is that surgeons favour revising a UKA to a TKA in cases of degeneration of the other femorotibial compartment rather than performing a relatively simple re-operation of the knee by doing an additional UKA (staged bi-UKA). Cite this article: <i>EFORT Open Rev</i> 2018;3:1-6. DOI: 10.1302/2058-5241.3.170021.
A symmetric deformation-based similarity measure for shape analysis (2015)

Statistical modeling of cellular/subcellular shapes is required for quantifying shape variations and understanding complex cell behaviors. Such statistical models rely on the choice of a proper similarity measure. In this paper we introduce a symmetric deformation-based similarity measure for cellular shape analysis. The proposed method is based on finding an optimal diffeomorphic mapping between shape images that minimizes a physically meaningful energy function. We compare our proposed method to the large deformation dif-feomorphic metric mapping (LDDMM) and the standard Euclidean metric on a nuclei dataset and show that the proposed method outperforms the others in capturing the variations in the dataset.
Supplementary Figure 1 from Cell Type–Specific, Topoisomerase II–Dependent Inhibition of Hypoxia-Inducible Factor-1α Protein Accumulation by NSC 644221 (2023)

Supplementary Figure 1 from Cell Type–Specific, Topoisomerase II–Dependent Inhibition of Hypoxia-Inducible Factor-1α Protein Accumulation by NSC 644221
Author response: Multi-scale mapping along the auditory hierarchy using high-resolution functional UltraSound in the awake ferret (2018)

Functional UltraSound imaging allows mapping tonotopic organisation in multiple auditory subcortical and cortical brain structures with an unprecedented spatial functional resolution, while giving access to long-distance top-down connectivity pattern from frontal cortex to auditory cortex.
Dual 1.5-MHz 3.5-kW versatile half-bridge series-resonant inverter module for inductive load characterization (2007)

This paper presents the challenges encountered and the solutions adopted during the construction of a versatile high-frequency series-resonant half-bridge voltage-fed inverter module. It is being used as the large-signal generator for an inductive load characterization test-bench which permits to obtain measurements in a real working situation over a wide frequency and output power operating conditions for a variety of loads. Square wave operation is established slightly above resonance under Zero Voltage Switching conditions to acquire near sinusoidal current and low losses. Output power is controlled by means of a variable DC bus and resonant conditions are fixed for each operating frequency by means of two adjustable resonant capacitor banks. The control of every test-bench block and the triggering waveform generation is performed digitally by means of a Field Programmable Gate Array. The modular approach and the flexible control implementation enable the utilization of several modules in parallel connection or full-bridge configuration widening the possibilities of load excitation. Final prototype covering the required operation range has been designed, and two modules have been constructed and evaluated for operation in half-bridge and full-bridge configurations showing rugged and stable operation during characterization of induction heating loads.
CCDC 622617: Experimental Crystal Structure Determination (2006)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Asymmetric Links Beamforming for mmWave Overlay in LTE-Based Heterogeneous Network (2017)

Traffic offloading to the millimeter-wave hotspots is an efficient way to increase the throughput and spectral efficiency of existing LTE networks. Such approach can be considered as first step towards 5G systems, but before the millimeter-wave overlay realize its full potential, several important problems should be solved. Firstly, the millimeter-wave coverage should be increased up to several hundred meters - and this is possible not only with implementation of high-gain steerable antennas, and usage of special beamforming algorithms. Secondly, the MU-MIMO should be introduced in the mmWave standards, which lead to significant increase of simultaneously served stations and therefore, substantial increase probability of collisions between them. In this paper we will show that both mentioned problems may be resolved with the proposed asymmetric links beamforming procedure. This enhanced beamforming was initially submitted and accepted as part of upcoming next-generation millimeter-wave standard: IEEE 802.11ay.
Retinoic acid-induced 2 (RAI2) is a novel tumor suppressor, and promoter region methylation of RAI2 is a poor prognostic marker in colorectal cancer (2018)

RAI2 is frequently methylated in human CRC, and the expression of RAI2 is regulated by promoter region methylation. Methylation of RAI2 is an independent poor prognostic marker of CRC. RAI2 suppresses CRC cell growth both in vitro and in vivo. RAI2 suppresses CRC by inhibiting AKT signaling.
X-ray standing-wave and tunneling-microscope location of gallium atoms on a silicon surface (1989)

The position of gallium atoms on a silicon (111) surface has been completely determined using the tunneling microscope and x-ray standing-wave methods. The (\ensuremath{\surd}3 \ifmmode\times\else\texttimes\fi{} \ensuremath{\surd}3 )R30\ifmmode^\circ\else\textdegree\fi{} electron diffraction pattern observed with (1/3-monolayer coverages is shown to result from a simple adatom gallium lattice with the adatoms at a distance 1.49 A\r{} above the bulk extrapolated surface (111) plane above the filled threefold silicon surface sites. Total-energy calculations correctly predict the binding site with the Ga 1.33 A\r{} above the bulk (111) plane.
Efficient High-Resolution Stereo Matching Using Local Plane Sweeps (2014)

We present a stereo algorithm designed for speed and efficiency that uses local slanted plane sweeps to propose disparity hypotheses for a semi-global matching algorithm. Our local plane hypotheses are derived from initial sparse feature correspondences followed by an iterative clustering step. Local plane sweeps are then performed around each slanted plane to produce out-of-plane parallax and matching-cost estimates. A final global optimization stage, implemented using semi-global matching, assigns each pixel to one of the local plane hypotheses. By only exploring a small fraction of the whole disparity space volume, our technique achieves significant speedups over previous algorithms and achieves state-of-the-art accuracy on high-resolution stereo pairs of up to 19 megapixels.
Selective catalytic reduction of NOx with ammonia (NH3-SCR) over copper loaded LEV type zeolites synthesized with different templates (2022)

LEV type zeolites were synthesized with four different structure-directing agents and converted to copper loaded NH<sub>3</sub>-SCR catalysts. The synthesis recipe was found to impact the respective Al population in the two topologically different framework sites in double and single 6-rings, resolvable by <sup>27</sup>Al MAS NMR spectroscopy. Hydrothermal stability was found to be related to the silanol concentration, Si/Al ratio, particle size, crystal morphology, crystal defects, external surface area, and microporosity. Catalytic activity in NH<sub>3</sub>-SCR was dependent on preferential Al siting in the double 6-rings. Levinite synthesized using adamantylamine showed the strongest preference for Al atoms sitting in double 6-ring sites, and showed the highest catalytic turnover frequency. Unfortunately, because of the large crystal size, copper loading of this sample was limited to 0.6 wt% while other samples could be loaded with copper up to 3.3 wt%. An optimum combination of hydrothermal stability and catalytic activity was obtained with <i>N</i>,<i>N</i>'-bis-dimethylpentanediyldiammonium dibromide as structure-directing agent.
Synthesis and in vitro cytotoxicity of 2-substituted 17-methylene/17-ß-methyl estratrienes (2013)

Ever since the first report on anticancer activity of human metabolite 2-methoxyestradiol 1, various types of 2-methoxyestradiol analogs have been synthesized and tested for their antiproliferative potential against cancer cell cultures. It has been proved that 2methoxy estradiol 1 inhibits microtubules and also acts as antiangiogenic agent (IC50 100 nm) . The tubulin polymerase inhibitory activity of 2methoxyestradiol is mediated through the colchicine binding-site of tubulin. The significant antiangiogenic activity and in vivo tubulin polymerization inhibition of 2-methoxyestradiol further encouraged its clinical trial. The antiproliferative efficacy displayed by 2-methoxyestradiol coupled with absence of any life threatening toxicity added further stimulus to the exploration of its analogs. Significant research work by Cushman and coworkers ascertained that steric as well as electronic factors at 2-position of estradiol are the major contributing factors for observed cytotoxicity and also antitubulin activity of 2-substituted estratrienes 1-4 (Ref 1,2,10-13), (Scheme I). Rao and coworkers synthesized a large number of metabolically stable Dring modified 2-methoxyestradiol analogs. Some of the compounds synthesized by Rao et al. displayed better cytotoxicity as well as antimitotic activity compared to that of 2-methoxyestradiol. Macdonald et al. synthesized a series of 2-methoxyestradiol analogs in which the A-ring of the steroid was replaced by substituted tropone rings. Indeed some of these compounds were also identified as better tubulin polymerase inhibitors than 2methoxyestradiol 1. Recently, synthesis and SAR profile of C-17 cyano-substituted estratrienes have been reported. Since, 2-methoxyestradiol is a promising drug for cancer therapy, synthesis of second generation derivatives with better bio-availability is highly essential. In continuation of the interest on SAR of 2-methoxyestradiol analogs, herein are reported some of the results on synthesis and anticancer activity of 2-substituted estratriene derivatives.
Phytochemical investigation of the fruits of Paliurus spina-christi Mill. (2019)

Paliurus spina-christi Mill. (Rhamnaceae) is a much-branched, deciduous, thorny shrub with green fruits that become brown during maturation. The shrub is found in dry slopes in Mediterranean, Southwest and Central Asia and North America. Its common name is ‘Christ’s thorn’ because it is said that its spiny branches were used to make the crown of thorns which had been placed on Christ’s head before his crucifixion. P. ramosissimus Lour., P. orientalis Franch. and P. hemsleyanus Rehder are well known species of the Eastern Asia [1]. Traditionally, P. spina-christi is used for its diuretic and anti-hypercholesterolemic properties, as well as a palliative against gastrointestinal pain [2]-[5]. Thus, it was decided to investigate the shrub’s fruits phytochemically.
Distribution of aroma volatile compounds in tangerine hybrids and proposed inheritance (2010)

The genetic background of tangerine hybrids affected volatile composition and content of samples. In general, tangerines were characterized by fewer volatiles (in both quality and quantity) and more aldehydes, and hybrids with sweet orange in their background had more sesquiterpenes and esters, which would likely affect their aroma.
Collective Response from a Cationic Tetrahedral Fluorene for Label‐Free DNA Detection (2007)

Abstract A cationic water‐soluble tetrahedral molecule bearing four phenylene‐bis(fluorene) optical units, namely tetrakis[4‐(2‐(9,9,9′,9′‐tetrakis( N , N , N ‐trimethylammoniumhexyl)‐7,2′‐bifluorenyl))‐phenyl]methane hexadecanebromide, was designed and synthesized. Fluorescence resonance energy transfer (FRET) experiments between the tetrahedral molecule and fluorescein‐labeled double stranded DNA (dsDNA‐Fl) or single stranded DNA (ssDNA‐Fl) were undertaken. Due to its specific shape and spatial registry, the tetrahedral molecule shows improved FRET efficiencies to dsDNA‐Fl as well as improved selectivity between dsDNA and ssDNA, when compared to a cationic conjugated polymer with similar repeat units. 30‐Fold signal amplification for dsDNA/ethidium bromide (EB) and selective response between complementary and non‐complementary DNA indicates that tetrahedral molecules could be useful to amplify the optical response from EB‐based DNA protocols.
Java for PDAs: Developing Mobile Applications for Handheld Devices (2002)

From the Publisher:
This practical hands-on solutions guide explains how to create applications for the second family of devices: PDAs, like Palm and Visor. The authors begin with a basic tutorial on J2ME and then dive right into a description of all the major topics for this new technolgoy.
Automated MEMS-based Drosophila embryo injection system for high-throughput RNAi screens (2006)

We have developed an automated system based on microelectromechanical systems (MEMS) injectors for reliable mass-injection of Drosophila embryos. Targeted applications are high-throughput RNA interference (RNAi) screens. Our injection needles are made of silicon nitride. The liquid to be injected is stored in an integrated 500 nl reservoir, and an externally applied air pressure pulse precisely controls the injected volume. A steady-state water flow rate per applied pressure of 1.2 nl s(-1) bar(-1) was measured for a needle with channel width, height and length of 6.1 microm, 2.3 microm and 350 microm, respectively. A typical volume of 60 pl per embryo can be reliably and rapidly delivered within tens of milliseconds. Theoretical predictions of flow rates match measured values within +/-10%. Embryos are attached to a glass slide surface and covered with oil. Packages with the injector chip and the embryo slide are mounted on motorized xyz-stages. Two cameras allow the user to quickly align the needle tip to alignment marks on the glass slide. Our system then automatically screens the glass slide for embryos and reliably detects and injects more than 98% of all embryos. Survival rates after deionized (DI) water injection of 80% and higher were achieved. A first RNAi experiment was successfully performed with double-stranded RNA (dsRNA) corresponding to the segment polarity gene armadillo at a concentration of 0.01 microM. Almost 80% of the injected embryos expressed an expected strong loss-of-function phenotype. Our system can replace current manual injection technologies and will support systematic identification of Drosophila gene functions.
Effect of Chronic Administration of Estrogen, Androgen, or Both on Serum Levels of Gonadotropins in Adult Men* (1978)

Ethinyl estradiol (50 micrograms/day) or fluoxymesterone (10 or 20 mg/day), chosen because each is orally active and because fluoxymesterone is probably not converted to an estrogen, were given alone and in combination to adult men over several weeks. Measurements were made of serum FSH, LH, testosterone, and estradiol. The estrogen given alone suppressed serum FSH while the androgen given alone did not; however, the androgen may have enhanced the suppressive effect of the estrogen on the serum FSH. Neither steroid alone changed the serum LH but both together suppressed it. The estrogen alone decreased the serum testosterone, an effect probably mediated by the concomitant fall in serum FSH and a resulting decrease in sensitivity to the constant level of LH; a direct effect of estrogen on the testis seems less likely. The doses of estrogen and androgen used probably had a biologic effect equal to or somewhat above that of endogenously produced estrogen and androgen and thus reflected the maximum physiological effects of the endogenous steroids. Thus, in the chronic physiological control of FSH and LH in adult men, these data indicate that (1) testosterone alone, as an androgen, has little effect on FSH or LH, (2) estradiol (or total estrogen) has a greater suppressive effect on FSH than on LH and by its effect on FSH may indirectly regulate the secretion of testosterone, and (3) testosterone and estradiol together may be involved in the regulation of both FSH and LH.
102 Exome Sequencing Identifies Novel Molecular Determinants of Human Congenital Hydrocephalus (2017)

Furey, Charuta Gavankar BA; Choi, Jungmin PhD; Duran, Daniel MD; Timberlake, Andrew T; Zeng, Xue; Nelson-Williams, Carol; Khanna, Arjun MD; Iskandar, Bermans MD; Butler, William MD; Heuer, Gregory George; Bayri, Yasar MD; Sahin, Yener BA, MD; Limbrick, David D MD, PhD; Warf, Benjamin C MD; Duncan, Charles C MD; DiLuna, Michael L MD; Gunel, Murat MD; Lifton, Richard P MD, PhD; Kahle, Kristopher Thomas MD, PhD
Retrospective multicenter analysis of 3i endosseous dental implants placed over a five‐year period (1996)

Osseointegrated dental implants have now become an accepted form of treatment for patients with a fully or partially missing dentition. The purpose of this study was to evaluate the performance of 3i threaded and cylindrical implants. During a 5-year period, a total of 1969 3i endosseous implants were placed at 6 centers in the United States and 2 elsewhere in the edentulous and partially edentulous jaws of 653 consecutive patients ranging in age from 18 to 82 years. Of the total number of implants placed, 1341 were commercially pure titanium threaded implants and 628 were titanium plasma-sprayed implants with a cylindrical configuration. A total of 28 patients with 110 implants were lost to follow-up. Implants in these patients were considered neither a success nor a failure. Success was predicated on the osseointegration of each and every implant followed in this analysis rather than the persistence of prosthetic function. Confirmed bone anchorage was considered essential for success. A total of 625 patients with 1871 implants remain in the study with a follow-up period ranging from 6 to 60 months. A total of 93 implants (5.0% of the total implants followed) were considered as failures. A mean implant survival rate was 95.0% for both the threaded and the cylindrical implant was calculated. The success rate of threaded implants was 97.0% in the mandible and 93.8% in the maxilla. The success rate for the 3.3-mm cylindrical implants was 96.0% in the mandible and 95.5% in the maxilla, and the success rate of 4.0-mm-diameter cylindrical implants was 95% in the mandible and 92.0% in the maxilla. Causes of failure consisted of loss of osseointegration (2.3%), crestal bone loss requiring periodontal therapy after the first year of function (1.7%) had mechanical problems associated with the prosthesis (0.9%). This retrospective analysis of the 3i endosseous implant system is comparable to previous reports on other implant systems in terms of implant survival and prosthesis stability. It is demonstrated that 3i implants are predictable and can provide lasting osseointegration leading to improvement of oral function if the recommended surgical and restorative protocol is followed.
Inorganic Photolithography: Interfacial Multicomponent Pattern Generation (1997)

Photolithography is one approach to the development of a "molecular architecture" of interfaces. To date, four different systems for creating high resolution inorganic microstructures through photolithography have been developed: Schanze and Meyer have used electrodes that have been chemically modified with an organometallic Ru polymer, Gafney has photolyzed metal carbonyls adsorbed into porous glass, and we have polymerized a multimetal, intervalent charge transfer complex onto ITO coated glass. Various features have been created, including Meyer's dots, Gafney's postage stamp sized periodic table, potential switchable grating of Schanze, and our potential switchable diffraction grating and reproduction of a full color American flag. Structures down to micron resolution have been demonstrated.
Abstract 5561: High-affinity antisense oligonucleotides targeting Foxp3 inhibit immunosuppressive function of regulatory T-cells and produce antitumor effects in syngeneic tumor models (2018)

Abstract Regulatory T-cells (Treg) contribute to cancer progression by suppressing anti-tumor immuity. Tregs specifically require expression of the lineage defining transcription factor Foxp3 for their development and function, but this protein cannot be targeted with conventional small molecule or biologic drugs. We employed next-generation antisense inhibitors (Gen 2.5 cEt-modified ASOs) in an attempt to selectively inhibit Foxp3 expression in mouse Treg cells, and evaluated consequences of ASO-mediated Foxp3 knock-down in vitro and in vivo. Mouse Foxp3-specific ASOs promoted potent dose-dependent reductions in Foxp3 mRNA and protein in vitro, without the use of transfection reagents. Foxp3 knockdown also resulted in loss of immunosuppressive markers and conferred Tregs with a reduced immunosuppressive capacity. Whilst genetic ablation of FOXP3 leads to manifestation of autoimmunity due to a complete loss of Treg function, we observed that the systemic delivery of unformulated mouse Foxp3 ASOs to WT mice resulted in Foxp3 knockdown in vivo, but spared mice from an autoimmune phenotype. Nevertheless, when syngeneic tumor-bearing mice were treated with mouse Foxp3 ASOs tumor growth was significantly attenuated, with a fraction of animals (25%-50%) achieving complete regressions. Anti-tumor activity of mouse Foxp3 ASOs was associated with immunophenotypic changes consistent with an increased anti-tumor immune response. Overall these data demonstrate the therapeutic capacity of mouse ASO to directly target regulatory T-cells, and suggesting that targeting of Foxp3 represents an attractive opportunity in cancer immunotherapy. Citation Format: Charles Sinclair, Alexey S. Revenko, Alison Peter, Robert B. Johnson, Lisa A. Hettrick, Molly Taylor, Anna Staniszewska, Adina Hughes, Lisa Sandin, Stephanie Klein, Andrew Watt, Simon Barry, Brett T. Monia, Paul Lyne, A Robert Macleod, Mark Edbrooke. High-affinity antisense oligonucleotides targeting Foxp3 inhibit immunosuppressive function of regulatory T-cells and produce antitumor effects in syngeneic tumor models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5561.