gebhart/patrepeval huggingface dataset:
Effect of Dietary Protein Level on Nitrogen Metabolism in the Growing Bovine: II. Diffusion into and Utilization of Endogenous Urea Nitrogen in the Rumen (1989)

Six Angus heifer calves (234 kg) were assigned to either a high (HP; 126.1 g N/d) or low (LP; 66.5 g N/d) protein intake to evaluate ruminal criteria associated with movement of blood urea-N (BUN)-derived NH3-N from the rumen wall into interior ruminal digesta. Calves received 4.8 kg DM/d of diets containing 30% cottonseed hulls and 70% cornsoybean meal in equal portions at 4-h intervals. Following single i.v. injections of 15N-urea, ruminal fluid was collected serially for 4 h postinjection from digesta located adjacent to the rumen wall (wall-proximate digesta; WPD) and from the center of the rumen digesta mass after manual agitation (center mixed digesta; CMD). Mean ruminal NH3-N (RAN) concentrations were higher (P less than .05) for HP than for LP, but were not affected (P greater than .05) by digesta sampling site. Ruminal urease activity was higher (P less than .05) for LP than for HP and tended (P = .14) to be higher for WPD than for CMD. Area under the 15N enrichment curve (AUC) ratios between sampling sites (WPD/CMD x 100) for RAN were greater (P less than .05) for LP than for HP. However, AUC ratios for bacterial N were not affected (P greater than .05) by protein level. Whereas BUN-derived 15NH3 appeared to thoroughly equilibrate with RAN in interior ruminal digesta with HP, there appeared to be a declining enrichment gradient for RAN from the rumen wall to the interior ruminal digesta with LP. Data are interpreted to suggest that bacteria at or near the rumen wall may preferentially utilize some BUN-derived NH3-N entering through the rumen wall in calves fed LP diets.
BK Virus Prophylaxis With Levofloxacin—Reply (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sketch2Mesh: Reconstructing and Editing 3D Shapes from Sketches (2021)

Reconstructing 3D shape from 2D sketches has long been an open problem because the sketches only provide very sparse and ambiguous information. In this paper, we use an encoder/decoder architecture for the sketch to mesh translation. When integrated into a user interface that provides camera parameters for the sketches, this enables us to leverage its latent parametrization to represent and refine a 3D mesh so that its projections match the external contours outlined in the sketch. We will show that this approach is easy to deploy, robust to style changes, and effective. Furthermore, it can be used for shape refinement given only single pen strokes.We compare our approach to state-of-the-art methods on sketches—both hand-drawn and synthesized—and demonstrate that we outperform them.
Metrics for Evaluating the Accuracy of Solar Power Forecasting (Presentation) (2013)

This presentation proposes a suite of metrics for evaluating the performance of solar power forecasting.
Stable transplantation of human mitochondrial DNA by high-throughput, pressurized isolated mitochondrial delivery (2021)

Generating mammalian cells with specific mitochondrial DNA (mtDNA)-nuclear DNA (nDNA) combinations is desirable but difficult to achieve and would be enabling for studies of mitochondrial-nuclear communication and coordination in controlling cell fates and functions. We developed 'MitoPunch', a pressure-driven mitochondrial transfer device, to deliver isolated mitochondria into numerous target mammalian cells simultaneousl<i>y</i>. MitoPunch and MitoCeption, a previously described force-based mitochondrial transfer approach, both yield stable isolated mitochondrial recipient (SIMR) cells that permanently retain exogenous mtDNA, whereas coincubation of mitochondria with cells does not yield SIMR cells. Although a typical MitoPunch or MitoCeption delivery results in dozens of immortalized SIMR clones with restored oxidative phosphorylation, only MitoPunch can produce replication-limited, non-immortal human SIMR clones. The MitoPunch device is versatile, inexpensive to assemble, and easy to use for engineering mtDNA-nDNA combinations to enable fundamental studies and potential translational applications.
Shrinkage of melanoma metastases following high dose intravenous immunoglobulin treatment. (2001)

Intravenous immunoglobulin is a preparation of normal polyspecific immunoglobulin G obtained from pooled plasma of a large number of healthy donors. In recent years IVIG has increasingly been used in the treatment of patients with a variety of autoimmune and systemic inflammatory diseases, including Kawasaki syndrome, dermatomyositis, systemic lupus erythematosus, antiphospholipid syndrome, and juvenile rheumatoid arthritis [1]. The effect of IVIG is mediated through several mechanisms, including inhibition of complement-mediated damage, changes in the inflammatory potential of circulating immune complexes, modulation of the relative production of pro-inflammatory and anti-inflammatory cytokines, modulation of expression of adhesion molecules and chemokines, and neutralization of microbial toxins [1].
Synthesis and Characterization of a Redox-Active Bis(thiophenolato)amide Ligand, [SNS]3–, and the Homoleptic Tungsten Complexes, W[SNS]2and W[ONO]2 (2013)

A new tridentate redox-active ligand platform, derived from bis(2-mercapto-p-tolyl)amine, [SNS(cat)]H(3), has been prepared in high yields by a four-step procedure starting from commericially available bis(p-tolyl)amine. The redox-active pincer-type ligand has been coordinated to tungsten to afford the six-coordinate, homoleptic complex W[SNS](2). To benchmark the redox behavior of the [SNS] ligand, the analogous tungsten complex of the well-known redox-active bis(3,5-di-tert-butylphenolato)amide ligand, W[ONO](2), also has been prepared. Both complexes show two reversible reductions and two partially reversible oxidations. Structural, spectroscopic, and electrochemical data all indicate that W[ONO](2) is best described as a tungsten(VI) metal center coordinated to two [ONO(cat)](3-) ligands. In contrast, experimental data suggests a higher degree of S→W π donation, giving the W[SNS](2) complex non-innocent electronic character that can be described as a tungsten(IV) metal center coordinated to two [SNS(sq)](2-) ligands.
Isolation and Function of Allophycocyanin B of Porphyridium (1977)

Allophycocyanin B was purified to homogeneity from the eukaryotic red alga Porphyridium cruentum. This biliprotein is distinct from the allophycocyanin of P. cruentum with respect to subunit molecular weights, and spectroscopic and immunological properties. The purified allophycocyanin B has a long wavelength absorption maximum at 669
Can P2P-Users Benefit from Locality-Awareness? (2010)

Locality-awareness is considered as a promising approach to increase the efficiency of content distribution by peer-to-peer (P2P) networks, e.g., BitTorrent. It is intended to reduce the inter-domain traffic which is costly for Internet service providers (ISPs) and simultaneously increase the performance from the viewpoint of the P2P users, i.e, shorten download times. This win-win situation should be achieved by a preferred exchange of information between peers which are located closely to each other in the underlying network topology. A set of studies shows that these approaches can lead to a win-win situation under certain conditions, and to a win-no lose situation in most cases. However, the scenarios used assume mostly homogeneous peer distributions and that all peers have the same access speed. This is not the case in practice according to several measurement studies. Therefore, we extend previous work in this paper by studying scenarios with real-life, skewed peer distributions and heterogeneous access bandwidths of peers. We show that even a win-no lose situation is difficult to achieve under those conditions and that the actual impact for a specific peer depends heavily on the used locality-aware peer selection and the concrete scenario. Therefore, we conclude that current proposals need to be refined so that users of P2P networks can be sure that they also benefit from their use. Otherwise, a broad acceptance of the concept of locality-awareness in the user community of P2P networks will not take place.
Using gamma‐cytokine complexes to improve antigen specific CD8 T cell responses in tumor‐bearing mice (2008)

In the absence of inflammatory signals, the exposure of T cells to tumor antigen in the periphery results in tolerance. Remaining tumor specific T cells are usually of low avidity or anergic. Immunotherapy aims at reversing this tolerance to induce an efficient T cell response. STAT5 Cytokines of the interleukin‐2 family signal through STAT5 and are candidates to increase T cell anti‐tumor response. The effects of these cytokines are greatly increased when the cytokine is complexed with a specific antibody. We have studied the potential of cytokine complexes to serve as adjuvants for CD8 cells activation in a murine model, RIP‐Tag2‐HA, in which pancreatic insulomas expressing the influenza hemagglutinin (HA) as a surrogate antigen develop spontaneously. HA specific CD8 cells become effector after 3 days of treatment with IL‐2 complexes and antigen in vivo . This differentiation leads to the elimination of endogenous tumors by high avidity HA specific CD8 cells. Survival of CD8 cells is increased by using the TLR ligands polyIC or by extending the length of treatment with IL‐2 complexes. Under such conditions, even low avidity HA specific CD8 cells eliminate the tumors. We further show that cytokine complexes also increase survival of adoptively transferred, ex‐vivo activated HA specific CD8 cells. These results indicate that IL‐2 complexes are strong adjuvants that greatly enhance tumor vaccines or immunotherapy.
Deposition behavior and diffusion barrier property of CVD MnO<inf>x</inf> (2009)

Chemical vapor deposition of MnOx (CVD-MnO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> ) was performed on blanket substrates as well as patterned interconnect structures. A conformal layer of MnO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> was formed by the MnO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> on SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> within a contact hole with a uniform thickness of 3 to 4 nm. Excellent diffusion barrier property was obtained after annealing at 400 degC. In contrast, the CVD-MnO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> on Cu formed solid solution with Cu. The solute Mn was migrated towards the interface of Cu/SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> to form MnO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> .
A Search Engine for Discovery of Biomedical Challenges and Directions (2021)

The ability to keep track of scientific challenges, advances and emerging directions is a fundamental part of research. However, researchers face a flood of papers that hinders discovery of important knowledge. In biomedicine, this directly impacts human lives. To address this problem, we present a novel task of extraction and search of scientific challenges and directions, to facilitate rapid knowledge discovery. We construct and release an expert-annotated corpus of texts sampled from full-length papers, labeled with novel semantic categories that generalize across many types of challenges and directions. We focus on a large corpus of interdisciplinary work relating to the COVID-19 pandemic, ranging from biomedicine to areas such as AI and economics. We apply a model trained on our data to identify challenges and directions across the corpus and build a dedicated search engine for this information. In studies with researchers, including those working directly on COVID-19, we outperform a popular scientific search engine in assisting knowledge discovery. Finally, we show that models trained on our resource generalize to the wider biomedical domain, highlighting its broad utility. We make our data, model and search engine publicly available. this https URL
Epitope‐specific CD4+, but not CD8+, T‐cell responses induced by recombinant influenza A viruses protect against Mycobacterium tuberculosis infection (2014)

Tuberculosis remains a global health problem, in part due to failure of the currently available vaccine, BCG, to protect adults against pulmonary forms of the disease. We explored the impact of pulmonary delivery of recombinant influenza A viruses (rIAVs) on the induction of Mycobacterium tuberculosis (M. tuberculosis)-specific CD4(+) and CD8(+) T-cell responses and the resultant protection against M. tuberculosis infection in C57BL/6 mice. Intranasal infection with rIAVs expressing a CD4(+) T-cell epitope from the Ag85B protein (PR8.p25) or CD8(+) T-cell epitope from the TB10.4 protein (PR8.TB10.4) generated strong T-cell responses to the M. tuberculosis-specific epitopes in the lung that persisted long after the rIAVs were cleared. Infection with PR8.p25 conferred protection against subsequent M. tuberculosis challenge in the lung, and this was associated with increased levels of poly-functional CD4(+) T cells at the time of challenge. By contrast, infection with PR8.TB10.4 did not induce protection despite the presence of IFN-γ-producing M. tuberculosis-specific CD8(+) T cells in the lung at the time of challenge and during infection. Therefore, the induction of pulmonary M. tuberculosis epitope-specific CD4(+), but not CD8(+) T cells, is essential for protection against acute M. tuberculosis infection in the lung.
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity (2020)

Host-defense peptides have drawn significant attention as new drugs or drug adjuvants to combat multidrug-resistant bacteria. In this study, we report the development of cyclic derivatives of the immunomodulatory and antibiofilm innate defense regulator peptide (IDR)-1018 based on three different synthetic strategies including head-to-tail cyclization (C1), side-chain-to-tail cyclization (C2), and a disulfide bond cross-linkage (C3). The generated mimetics showed enhanced proteolytic stability and reduced aggregation in vitro and in vivo. The C2 derivative exhibited exceptional ability to suppress inflammation and significantly reduce bacterial loads in a high-density <i>Staphylococcus aureus</i> murine skin infection model. The findings describe different routes to the creation of enzymatically stable mimetics of IDR-1018 and identify a promising new cyclic analogue against bacterial infections.
Thermal stress implications in athermal TiO_2 waveguides on a silicon substrate (2014)

Ring resonators with TiO2 core confinement factors from 0.07 to 0.42 are fabricated and measured for thermal sensitivity achieving -2.9 pm/K thermal drift in the best case. Materials used are CMOS compatible (TiO2, SiO2 and Si3N4) on a Si substrate. The under discussed role of stress in thermo-optic behavior is clearly observed when contrasting waveguides buried in SiO2 to those with etched sidewalls revealed to air. Multiphysics simulations are conducted to provide a theoretical explanation of this phenomenon in contrast to the more widely reported theories on thermo-optic behavior dominated by confinement factor.
Michael E. Fisher - teacher, mentor, colleague and friend: a (very) personal account (2023)

The only rational way of educating is to be an example. If one cant help it, a warning example. Albert Einstein. I had the good fortune and privilege of having Michael Fisher as my teacher, supervisor, mentor and friend. During my years as a scientist, teacher and supervisor of about one hundred students and post docs I found myself innumerable times realizing that I am following or at least trying to follow Michaels example. These pages are my attempt to convey recollections of my association with Michael, focusing on how he served as an example for me.
Reactions of the metallodrug auranofin [(1-thio-.beta.-D-glucopyranose-2,3,4,6-tetraacetato-S)(triethylphosphine)gold] with biological ligands studied by radioisotope methodology (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of the metallodrug auranofin [(1-thio-.beta.-D-glucopyranose-2,3,4,6-tetraacetato-S)(triethylphosphine)gold] with biological ligands studied by radioisotope methodologyD. J. Ecker, J. C. Hempel, B. M. Sutton, R. Kirsch, and S. T. CrookeCite this: Inorg. Chem. 1986, 25, 18, 3139–3143Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/ic00238a009https://doi.org/10.1021/ic00238a009research-articleACS PublicationsRequest reuse permissionsArticle Views176Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Future Use and Development of Expert System Technology in Horticulture (1993)

Decreasing resources and increasing complexity of horticultural crop production necessitate that new technologies be developed to transfer information to commercial producers. Expert systems (ES) have been cited as potential tools that can facilitate knowledge transfer. The definitions of an expert system, however, technically only indicates a computer program that simulates the thought processes of a human expert and, as such, does not supply all the facets necessary to assist commercial producers. The combination of databases, graphic capabilities, and textual information into a comprehensive program would provide a more complete package. To differentiate the two, we use the term decision support systems (DSS). The development, testing, and release of DSS, however, require greater commitment and interdisciplinary cooperation. Developing DSS fosters interstate, interregional, and international cooperation among researchers and extension personnel. Using systems developed in fruit production as examples, we outline the value of DSS to promote cooperation, the resources necessary to develop these systems; and the attitudinal change necessary to build the systems.
A General Approach to Dehydro-Freidinger Lactams:  Ex-Chiral Pool Synthesis and Spectroscopic Evaluation as Potential Reverse Turn Inducers (2002)

Starting from natural alpha-amino acids, a practical synthesis of the dehydro-Freidinger lactams 9a-h based on the ring-closing olefin metathesis reaction was investigated. The presented examples comprise 6-, 7-, 8-, 9-, and 10-membered cyclic dipeptide mimics. Structural variations were demonstrated. We approached the metathesis precursors 8a-h employing an N-alkylation/peptide-coupling strategy. Subsequent ring closure was promoted by the ruthenium-based catalyst 10a or 10b. The resulting tetraresidue 11d was shown to undergo intramolecular hydrogen bonding based on NMR and FT-IR studies. Thus, the development of dehydro-Freidinger lactams as potential reverse turn inducers stabilizing an intramolecular NH(i+3)...CO(i) hydrogen-bond was demonstrated.
Traditional Banding of Chromosomes for Cytogenetic Analysis (2004)

Traditional banding of metaphase chromosomes allows identification of individual chromosomes and detection of gross chromosomal anomalies and abnormal chromosome structures. Giemsa (G) banding is the older and more familiar nonfluorescent technique that produces characteristic banding patterns. DAPI , a fluorescent DNA stain, produces banding patterns similar to those of G-banding and is much simpler to perform.
DC magnetron sputtering deposition and characterisation of gold oxide thin films (2010)

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Stimulated Deep Neural Network for Speech Recognition (2016)

Deep neural networks (DNNs) and deep learning approaches yield state-of-the-art performance in a range of tasks, including speech recognition.However, the parameters of the network are hard to analyze, making network regularization and robust adaptation challenging.Stimulated training has recently been proposed to address this problem by encouraging the node activation outputs in regions of the network to be related.This kind of information aids visualization of the network, but also has the potential to improve regularization and adaptation.This paper investigates stimulated training of DNNs for both of these options.These schemes take advantage of the smoothness constraints that stimulated training offers.The approaches are evaluated on two large vocabulary speech recognition tasks: a U.S. English broadcast news (BN) task and a Javanese conversational telephone speech task from the IARPA Babel program.Stimulated DNN training acquires consistent performance gains on both tasks over unstimulated baselines.On the BN task, the proposed smoothing approach is also applied to rapid adaptation, again outperforming the standard adaptation scheme.