gebhart/patrepeval huggingface dataset:
Cortical representations of learned vibrotactile stimuli (1991)

Recent electrophysiological studies have shown that cortical somatosensory representations are shaped by tactual experiences. These adaptive neuronal processes underlying cortical contributions to tactual learning and nondeclarative memory have been studied by: (a) distorting the factual experiences of monkeys and rats over a limited time epoch; (b) determining the consequences of special skin and peripheral nerve manipulations that test hypotheses about the neural network origins and cortical plasticity; (c) evaluating the consequences, for cortical representation and cortical network organization, of the perturbation of the network by microstimulation; and (d) training monkeys to make distinctions about tactile stimuli while tracking training-induced changes in their cortical representations. These studies bear significance for understanding the neural origins of tactile perception, and provide a basis for understanding how idiosyncratic tactual perceptual abilities emerge from tactile experience. [Work supported by NIH Grant NS-10414, the Coleman Fund, and Hearing Research, Inc.]
A single-centre experience of patients with metastatic melanoma enrolled in a dabrafenib named patient programme (2014)

We studied the efficacy, tolerability and clinical courses of dabrafenib in patients with metastatic melanoma who were ineligible for enrolment into a clinical trial. Between July 2011 and May 2013, patients with unresectable stage III or stage IV, V600-mutated metastatic melanoma who were not eligible for inclusion into clinical trials were offered treatment with dabrafenib through a named patient programme. Routine efficacy and toxicity data were collected throughout treatment and studied retrospectively. The endpoints were progression-free survival (PFS), overall survival and best overall response. Thirty-one patients commenced dabrafenib therapy including six individuals who had progressed on a prior BRAF-inhibitor treatment. The majority of patients had cerebral metastases (n=17) and/or a poor performance status [Eastern Cooperative Oncology Group (ECOG)≥2, n=11]. Median overall survival was 5.6 months (range 0.1-22 months). Median PFS was 3.3 months (range 0.1-21) and was similar despite performance status. One patient had a complete response and eight showed partial responses to treatment. Patients with cerebral metastases (n=17) had a median PFS of 4.6 months. Five patients (16%) had dose-limiting toxicities. Despite several poor prognostic features, dabrafenib is a safe and effective treatment in the community setting, with occasional impressive outcomes.
Supplementary Material 6 from Androgen Glucuronidation: An Unexpected Target for Androgen Deprivation Therapy, with Prognosis and Diagnostic Implications (2023)

&lt;p&gt;PDF file - 6791K, Supplementary material 6: Representative examples of immunoexpression obtained after incubation of prostate tissue microarrays with the anti-UGT2B15, anti-UGT2B17 or anti-vimentin antibodies: Comparison Untreated vs ADTh for 9.0 months.&lt;/p&gt;
Nanometer Metrology Using Ultrafast Optoacoustics (2009)

We present a method for accessing nanoscale dimensions in semiconductor wafer metrology, using ultrafast optoacoustic ranging. One illustrative example is the measurement of dimensions and profile of nanometer scale deep trenches in silicon-wafer based structures.
Multiple image SAR shape-from-shading (1991)

A technique for combining radar image shape-from-shading with stereo radargrammetry to produce terrain surface models using multiple SAR images is described. This technique is expected to be of use to reconstruct surface shape from Magellan images of planet Venus, and to refine the results of terrestrial radar measurements. Local variation in pixel shading is an indicator of terrain slope changes. This variation in pixel shading offers an opportunity for increasing the detail of terrain mapping over that which is available from stereo radargrammetry alone. Shape-from-shading can potentially provide a relative change in height at each pixel. This leads to a dense set of height measurements and a more faithful rendition of the local terrain shapes. However, shape-from-shading needs some type of boundary values or external terrain low-frequency information to succeed. These can be obtained from stereo or from altimeter measurements.
DNA sequence preferences for the anti‐cancer drug mitoxanthrone and related anthraquinones revealed by DNase I footprinting (1986)

The interaction has been studied of several anthraquinone-based intercalating drugs, including the anti-cancer agent mitoxantrone, with defined sites of DNA. A 160 base pair DNA sequence from tyrT was employed for footprinting with DNase I. The anthraquinones had aminoalkylamino substituents in various positions of the ring system. Inhibition of enzymatic cutting of the DNA was observed at various positions on the sequence, mostly around some of the pyrimidine-3',5'-purine sites. Enhancements to cutting were observed clustered around AT-rich regions. The compounds showed differences in detailed footprinting behaviour, which have been related to differences in their mode of interaction with DNA as found in earlier computer modelling studies.
Computational Intelligence, Bioinformatics and Computational Biology: A Brief Overview of Methods, Problems and Perspectives (2005)

The paper is an overview of methods of computational intelligence (CI) used in the area of Bioinformatics (BI) for the purpose of advancing the area Computational Biology (CB) and facilitating discoveries from biological data. CI is the area of developing generic intelligent information processing methods and systems with wider applications, one of them being Bioinformatics. CI adopts many principles from Biology, thus offering suitable methods and tools for BI. While CB aims at understanding the biology principles through their computational modeling, BI is aiming at the use and the development of new information methods and systems to enhance the storage, the analysis, modeling, and discovery from biological data. The synergism between the three disciplines, their methodologies, problems, and some current solutions are review in the paper. Some new methods and experimental results are introduced, such as feature and model optimization with genetic algorithms applied on gene expression data.
First observation of the decay D0→K−π+μ+μ− in the ρ0–ω region of the dimuon mass spectrum (2016)

First observation of the decay D 0 K - + + -in the 0 - region
Discovery of reversible photochromism in titanium dioxide using photoacoustic spectroscopy: implications for the investigation of light-induced charge-separation and surface redox processes in titanium dioxide (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiscovery of reversible photochromism in titanium dioxide using photoacoustic spectroscopy: implications for the investigation of light-induced charge-separation and surface redox processes in titanium dioxideJames G. Highfield and Michael GraetzelCite this: J. Phys. Chem. 1988, 92, 2, 464–467Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/j100313a043https://doi.org/10.1021/j100313a043research-articleACS PublicationsRequest reuse permissionsArticle Views366Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Glass transition and molecular mobility in polymer thin films (2009)

Extensive studies on polymer thin films to date have revealed their interesting but unusual properties such as film thickness dependence of glass transition temperature Tg and thermal expansivity. Recent studies have shown that the lower Tg is not always related to the higher mobility in polymer thin films, which contradicts our current understanding of the glass transition process. In this work, we report the results of inelastic neutron-scattering measurements on polystyrene thin films using two spectrometers with different energy resolutions as well as ellipsometry measurements. The results are interpreted in terms of cooperatively rearranging region and motional slowing down due to the surface effect that explain plausibly the anomalous relationship between the glass transition temperature Tg and the molecular mobility in thin films.
Photonic and nanobiophotonic properties of luminescent lanthanide-doped hybrid organic–inorganic materials (2007)

Research into lanthanide-doped organic–inorganic hybrid materials emerged in the 1990s with the development of interesting materials for optics: high efficiency and stable solid-state lasers, new fiber amplifiers and sensors, devices with upconversion, fast photochromic and non-linear responses, etc. Their interest relies on the possibility of combining properties of sol–gel host materials (shaping, tunable refractive index and mechanical properties, corrosion protection, specific adhesion, etc.) and the well-known luminescence of lanthanide ions (Ln). The fast development of photonic hybrids allowed the commercial exploitation of products with new or enhanced characteristics (megajoule pulsed Nd-YAG laser, protective coatings of glasses, screens or glasswares). However, recently, Ln-hybrid nanocomposites have found new applications in bio-sensors, bio-analytics and even clinical imaging diagnostics. These applications make use of the fluorescence properties of lanthanides that make luminescent hybrids ideal candidates for time-resolved fluoroimmunoassays, DNA hybridation assays, fluorescence imaging microscopy, or in vivo imaging. As a consequence, the goal of this review is twofold: (i) as a reminder of some general considerations that must be taken into account to design new optically active Ln-doped nanocomposites whatever the application field, and (ii) to show the most important advances achieved in the past years in different areas, paying special attention to bio-medical applications.
MicroRNA-183-3p Is a Predictor of Worsening Heart Failure in Adult Patients With Transposition of the Great Arteries and a Systemic Right Ventricle (2021)

<b>Aim:</b> MicroRNAs (miRNAs) have been shown to play an important role in the progression of heart failure (HF). The aim of our study was to analyze miRNAs in the blood of patients with transposition of the great arteries and a systemic right ventricle (TGA-RV) in order to identify those that predict worsening HF. <b>Materials and Methods:</b> In 36 patients with TGA-RV, SurePrint™ 8 × 60K Human v21 miRNA microarrays were used to determine the miRNA abundance profiles and compared to 35 age- and gender-matched healthy volunteers (HVs). MiRNAs that were most significantly abundant or best related to worsening HF were further validated by RT-qPCR. <b>Results:</b> Using miRNA array analysis, a total of 50 down-regulated and 56 up-regulated miRNAs were found to be differentially abundant in TGA-RV patients compared to HVs. Six of these 106 miRNAs were significantly related to worsening HF. After validation by RT-qPCR, four miRNAs turned out to be significantly associated with worsening HF, namely miR-150-5p, miR-1255b-5p, miR-423-3p, and miR-183-3p. In the stepwise multivariable Cox regression analysis, ejection fraction of the systemic RV, high sensitive TNT and miR-183-3p were found to be independent predictors of worsening HF (<i>P</i> = 0.001, <i>P</i> = 0.002, and <i>P</i> = 0.001, respectively). <b>Conclusions:</b> In patients with TGA-RV, miR-183-3p is an independent predictor of worsening HF and thus may be used as additional biomarker in the risk assessment of these patients.
X-RAY CRYSTAL STRUCTURE OF NEODYMIUM NITRATE COMPLEX WITH TETRAETHYLENE GLYCOL (1981)

Abstract Neodymium atom is decacoordinated with oxygen atoms in the title complex, where tetraethylene glycol acts as a pentadentate ligand, forming a ring-like structure together with a unidentate nitrate. Two bidentate nitrates coordinate to neodymium atom from above and below the plane formed by tetraethylene glycol.
Supplementary Figure 4 from Dysfunctional Microvasculature as a Consequence of <i>Shb</i> Gene Inactivation Causes Impaired Tumor Growth (2023)

Supplementary Figure 4 from Dysfunctional Microvasculature as a Consequence of &lt;i&gt;Shb&lt;/i&gt; Gene Inactivation Causes Impaired Tumor Growth
Radio-over-fiber photonic wireless bridge in the W-Band (2013)

In this paper, we present a photonic wireless system operating in the W-Band (75-110 GHz) featuring ultra-high bandwidth as well as simple NRZ-OOK modulation format. By using a cascaded optical RF and data modulation approach on the transmitter side, flexible adjustment of the wireless RF carrier in the W-Band is achieved, while direct electrical to optical conversion with advanced photonic components on the receiver side enables true photonic wireless bridging. In first experiments, data rates up to 10 Gb/s have been experimentally demonstrated.
The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee (2022)

Since the publication of the Revised European-American Classification of Lymphoid Neoplasms in 1994, subsequent updates of the classification of lymphoid neoplasms have been generated through iterative international efforts to achieve broad consensus among hematopathologists, geneticists, molecular scientists, and clinicians. Significant progress has recently been made in the characterization of malignancies of the immune system, with many new insights provided by genomic studies. They have led to this proposal. We have followed the same process that was successfully used for the third and fourth editions of the World Health Organization Classification of Hematologic Neoplasms. The definition, recommended studies, and criteria for the diagnosis of many entities have been extensively refined. Some categories considered provisional have now been upgraded to definite entities. Terminology for some diseases has been revised to adapt nomenclature to the current knowledge of their biology, but these modifications have been restricted to well-justified situations. Major findings from recent genomic studies have impacted the conceptual framework and diagnostic criteria for many disease entities. These changes will have an impact on optimal clinical management. The conclusions of this work are summarized in this report as the proposed International Consensus Classification of mature lymphoid, histiocytic, and dendritic cell tumors.
Molecular characterisation and genetic mapping of candidate genes for qualitative disease resistance in perennial ryegrass (Lolium perenne L.) (2009)

This study is the most comprehensive analysis to date of qualitative disease resistance candidate genes in perennial ryegrass. SNPs identified within candidate genes provide a valuable resource for mapping in various ryegrass pair cross-derived populations and further germplasm analysis using association genetics. In parallel with the use of specific pathogen virulence races, such resources provide the means to identify gene-for-gene mechanisms for multiple host pathogen-interactions and ultimately to obtain durable field-based resistance.
Mechanical Mesh Segmentation and Global 3D Shape Extraction (2014)

This paper presents a method for segmenting noisy 2-manifold meshes based on a decomposition into local shape primitives maximizing global coherence. This technique works by partitioning the input mesh into regions which can be approximated by a simple geometrical primitive such as a plane, a sphere or a cylinder. The proposed approach is entirely error-driven, convergence-proven, and does not need to specify a number of segments. The partitioning is guided by robust shape extractions based on RANSAC sampling and by a global graphical model which regularizes the segmented regions. The final decomposition is based on the minimum of the energy associated with this graphical model. Obtained segmentations on noisy mechanical meshes outperform other approaches in terms of region contour correctness and consistency with mechanical object decomposition. Applications of this work are reverse engineering, mesh structure analysis, mesh feature enhancement, noise removal, mesh compression, piecewise approximation of mesh geometry, and remeshing.
Synthesis and Biological Activity of Analogues of the Antidiabetic/Antiobesity Agent 3-Guanidinopropionic Acid:  Discovery of a Novel Aminoguanidinoacetic Acid Antidiabetic Agent (2001)

3-Guanidinopropionic acid (1, PNU-10483) has been demonstrated to both improve insulin sensitivity and to promote weight loss selectively from adipose tissue in animal models of non-insulin-dependent diabetes mellitus (NIDDM). However, 1 has also been shown to be a substrate for both the creatine transporter and creatine kinase, leading to marked accumulation in muscle tissue as the corresponding N-phosphate 4. In an effort to identify novel entities that maintain antidiabetic potency without susceptibility to creatine-like metabolism, an analogue program was undertaken to explore the effects of various structural modifications, including homologation, simple substitution, single atom mutations, and bioisosteric replacements for the guanidine and carboxylic acid. Overall, the scope of activity encompassed by the set of new analogues proved to be exceedingly narrow. Notable exceptions demonstrating equivalent or improved antidiabetic activity included the alpha-amino derivative 29, aminopyridine 47, isothiourea 67, and aminoguanidine 69. On the basis of its superior therapeutic ratio, aminoguanidine 69 was selected for preclinical development and became the foundation for a second phase of analogue work. Furthermore, in vitro studies demonstrated that 69 is markedly less susceptible to phosphorylation by creatine kinase than the lead 1, suggesting that it should have less potential for accumulation in muscle tissue than 1.
Safety Evaluation of a Multiallergen Immunotherapy Treatment in Polyallergic Patients. APOLO Observational Study (2020)

<b>Aim:</b> Assessment of safety, tolerability and changes in global clinical impression with an multiallergen immunotherapy treatment without dilutional effect in polyallergic patients. <b>Patients & methods:</b> This observational prospective study included patients with allergic rhinitis-rhinoconjunctivitis with or without asthma between 5 and 60 years old receiving immunotherapy treatment with a mixture of two allergenic sources. All adverse events were recorded. Global clinical impression, tolerability subjective assessment and satisfaction were also assessed. <b>Results:</b> 130 patients were analyzed. Nine clinically relevant local adverse reactions were reported in six patients (4.6%). Six systemic reactions (grades 0-I) occurred in four patients (3.1%). Patients improved significantly in their global clinical impression. Good tolerability subjective assessment and satisfaction values were also observed. <b>Conclusion:</b> This multiallergen immunotherapy treatment without dilutional effect can be considered as a potential therapeutic alternative for polyallergic patients suffering from allergic rhinitis.
Radiation-Enhanced Lung Cancer Progression in a Transgenic Mouse Model of Lung Cancer Is Predictive of Outcomes in Human Lung and Breast Cancer (2014)

These results demonstrate that radiation exposure can cooperate with benign lesions in a transgenic model of cancer by affecting inflammatory pathways, and that clinically relevant similarities exist between human lung and breast carcinogenesis.
Drug Delivery Systems (2004)

Abstract The rapid advancement of biomedical research has led to many creative applications for biocompatible polymers. As modern medicine discerns more mechanisms of both physiology and pathophysiology, the approach to healing is to mimic, or if possible, to recreate the physiology of healthy functioning. Thus, the area of responsive drug delivery has evolved. Also called “smart” polymers, for drug delivery, the developments fall in two categories: externally regulated or pulsatile systems (also known as “open‐loop” systems) and self‐regulated systems (also called “closed‐loop”). The fundamentals of this research area a detailed account of the most recent advances in both pusatile and self‐regulated drug delivery systems are detailed. Controlled release technologies present an invaluable scientific and practical tool for improving performance and safety of drugs. These technologies involve designing the system of materials/drugs/site of action in such a way that barriers surrounding the drug to deliver the latter act with efficacy and safety of the drug at the optimum time and the rate needed. Advances in polymer science have led to the development of several novel drug delivery systems. A proper consideration of surface and bulk properties can aid in designing of polymeric systems for various drug delivery applications. This article is an overview of polymeric controlled release technology starting from fundamentals to applications.
Localization of metabotropic glutamate receptor 7 mRNA and mGluR7a protein in the rat basal ganglia (1999)

Metabotropic glutamate receptors (mGluRs) coupled to G-proteins have important roles in the regulation of basal ganglia function. We have examined the localization of the mGluR7 mRNA and mGluR7a protein in the basal ganglia of the rat. Strong mGluR7 hybridization signals are found in cerebral cortex and striatum, but much less intense signals are present in other components of the basal ganglia. Abundant mGluR7a immunoreactivity was found in striatum, globus pallidus (GP), and substantia nigra pars reticulata (SNr). Examination using confocal microscopy together with dendritic and presynaptic markers as well as studies in lesion models provided evidence for the presence of mGluR7a on presynaptic terminals in all three structures. Electron microscopic studies confirmed the presence of mGluR7a in axon terminals in both the striatum and the GP and also revealed the presence of mGluR7a at postsynaptic sites in both of these regions. Our data demonstrate that mGluR7a is located not only on presynaptic glutamatergic terminals of the corticostriatal pathway, where it may serve as an autoreceptor, but also on terminals of striatopallidal and striatonigral projections, where it may modulate the release of gamma-aminobutyric acid (GABA). The presence of mGluR7 at these multiple sites in the basal ganglia suggests that this receptor has a particularly crucial role in modulating neurotransmitter release in major basal ganglia pathways.