gebhart/patrepeval huggingface dataset:
EXTH-64. IMIPRIDONES CAUSE METABOLIC REPROGRAMMING AND ELICIT UNIQUE VULNERABILITIES IN PRECLINICAL MODEL SYSTEMS OF GLIOBLASTOMA (2018)

The purpose of this study is to improve the efficacy of imipridones, a novel class of AKT/ERK inhibitors. The lead compound ONC201 has entered clinical testing for glioblastoma (GBM) and recently chemically modified imipridones, ONC206 and ONC212, have been designed. Transcriptome, untargeted liquid chromatography/mass spectrometry and extracellular flux analysis unraveled the mechanism of action of novel imipridone compounds, ONC206 and ONC212. We used orthotopic patient-derived GBM xenografts to assess preclinical treatment efficacy. Imipridones inhibit the proliferation of patient-derived xenograft and stem-like glioblastoma cell cultures in vitro and in multiple xenograft models in vivo. ONC212 demonstrated the highest efficacy. High levels of c-myc predict susceptibility to cell death induction by imipridones and increased host survival in orthotopic patient-derived xenografts. At 1h, imipridones inhibit AKT and ERK signaling, accompanied by dephosphorylation of GSK3b. GSK3b phosphorylates c-myc at threonine 58, leading to its proteasomal degradation. Imipridone mediated suppression of c-myc inhibits both glycolysis and oxidative phosphorylation. In turn, energy deprivation leads to a compensatory activation of the serine-one carbon-glycine (SOG) pathway. Interference with the SOG pathway through novel inhibitors of phosphoglycerate dehydrogenase (PHGDH) results in synergistic apoptosis induction in vitro and in vivo. These observations suggest that c-myc expression predicts therapeutic responses to imipridones and that imipridone mediated inhibition of c-myc leads to suppression of tumor cell energy metabolism, eliciting unique metabolic vulnerabilities that can be exploited for clinical relevant drug combination therapies.
DSP-based sensorless speed control drive system for two-phase synchronous motors (2015)

A basic direct torque control (DTC) drive system enables effective control of stator flux modulus and electromagnetic torque. This high performance method can be further improved to a sensorless speed control method, which adjusts the stator flux modulus and motor speed. Based on the DTC method, this paper proposes a sensorless speed control drive system for two-phase synchronous motors. The block diagram of the two-phase sensorless speed control drive is proposed. The small-signal model of the system is then derived based on the proposed block diagram of the system. Based on the small-signal model of the system, the phase margin and crossover frequency of the gain of the control loop are calculated and then used for the design of the speed controller. The design process of the speed controller is verified using Bode plot. The effectiveness of the proposed two-phase sensorless speed control drive system is validated by an experimental setup using a TMS320F2812 digital signal processor (DSP).
Smart Channel State Information Pre-processing for Joint Authentication and Symmetric Key Distillation (2022)

&lt;p&gt;While the literature on RF fingerprinting-based authentication and key distillation is vast, the two topics have customarily been studied separately. &lt;/p&gt; &lt;p&gt;In this paper, starting from the observation that the wireless channel is a composite, deterministic / stochastic process, we propose a power domain decomposition that allows performing the two tasks simultaneously. We devise intelligent pre-processing schemes to decompose channel state information (CSI) observation vectors into ``predictable'' and ``unpredictable'' components. The former, primarily due to large-scale fading, can be used for node authentication through RF fingerprinting. The latter, primarily due to small-scale fading, could be used for semantically secure secret key generation (SKG). To perform the decomposition, we propose: (i) a fingerprint ``separability'' criterion, expressed through the maximisation of the total variation distance between the empirical fingerprint measures; (ii) a statistical independence metric for observations collected at different users, expressed through a normalised version of the $d$-dimensional Hilbert Schmidt independence criterion (dHSIC) test statistic. We propose both explicit implementations, using principal component analysis (PCA) and kernel PCA and black-box, unsupervised learning, using autoencoders. Our experiments on synthetic and real CSI datasets showcase that the incorporation of RF fingerprinting and SKG, with explicit security guarantees, is tangible in future generations of wireless. &lt;/p&gt; &lt;p&gt;&lt;br&gt;&lt;/p&gt;
Toward a Meningitis-Free World (2012)

Meningococcal meningitis is a devastating disease that is often fatal. Vaccines against the five major meningococcal serogroups causing disease are about to become available, a conjugate vaccine against meningococcus A is in use for mass vaccination in Africa, and a protein-based vaccine against meningococcal B is ready for licensure. With the availability of these new vaccines, the world can finally be rid of meningococcal meningitis, thus rewriting a new chapter in medical history.
Prospective study of brentuximab vedotin in relapsed/refractory Hodgkin lymphoma patients who are not suitable for stem cell transplant or multi‐agent chemotherapy (2018)

Some patients with relapsed/refractory Hodgkin lymphoma (HL) are not considered suitable for stem cell transplant (SCT) and have a poor prognosis. This phase IV study (NCT01990534) evaluated brentuximab vedotin (1·8 mg/kg intravenously once every 3 weeks) in 60 patients (aged ≥18 years) with CD30-positive relapsed/refractory HL, a history of ≥1 prior systemic chemotherapy regimen, who were considered unsuitable for SCT/multi-agent chemotherapy. Primary endpoint was overall response rate (ORR) per independent review facility (IRF). Secondary endpoints included duration of response (DOR), progression-free survival (PFS) per IRF, overall survival (OS), proportion proceeding to SCT and safety. The ORR was 50%, with 12% CR; 47% proceeded to SCT. Median DOR was 4·6 months and median duration of CR was 6·1 months. After a median follow-up of 6·9 and 16·6 months, median PFS and OS were 4·8 months (95% confidence interval, 3·0-5·3) and not reached, respectively; estimated OS rate was 86% at 12 months. Most common adverse events (≥10%) were peripheral neuropathy (35%), pyrexia (18%), diarrhoea and neutropenia (each 10%). Brentuximab vedotin showed notable activity with a safety profile consistent with known toxicities, and may act as a bridge to SCT, enabling high-risk patients who achieve suboptimal response to frontline/salvage chemotherapy/radiotherapy to receive potentially curative SCT.
Protection against Tuberculosis with Homologous or Heterologous Protein/Vector Vaccine Approaches Is Not Dependent on CD8+ T Cells (2013)

Considerable effort has been directed to develop Mycobacterium tuberculosis vaccines to boost bacille Calmette-Guérin or for those who cannot be immunized with bacille Calmette-Guérin. We hypothesized that CD4(+) and CD8(+) T cell responses with a heterologous prime/boost vaccine approach could induce long-lived vaccine efficacy against M. tuberculosis in C57BL/6 mice. We produced an adenovirus vector expressing ID93 (Ad5-ID93) for induction of CD8 T cells to use with our candidate tuberculosis vaccine, ID93/glucopyranosyl lipid adjuvant (GLA)-stable emulsion (SE), which induces potent Th1 CD4 T cells. Ad5-ID93 generates ID93-specific CD8(+) T cell responses and induces protection against M. tuberculosis. When Ad5-ID93 is administered in a prime-boost strategy with ID93/GLA-SE, both CD4(+) and CD8(+) T cells are generated and provide protection against M. tuberculosis. In a MHC class I-deficient mouse model, all groups including the Ad5-ID93 group elicited an Ag-specific CD4(+) T cell response and significantly fewer Ag-specific CD8(+) T cells, but were still protected against M. tuberculosis, suggesting that CD4(+) Th1 T cells could compensate for the loss of CD8(+) T cells. Lastly, the order of the heterologous immunizations was critical. Long-lived vaccine protection was observed only when Ad5-ID93 was given as the boost following an ID93/GLA-SE prime. The homologous ID93/GLA-SE prime/boost regimen also induced long-lived protection. One of the correlates of protection between these two approaches was an increase in the total number of ID93-specific IFN-γ-producing CD4(+) T cells 6 mo following the last immunization. Our findings provide insight into the development of vaccines not only for tuberculosis, but other diseases requiring T cell immunity.
Optimal Flexibility Control of Large-Scale Distributed Heterogeneous Loads in the Power Grid (2019)

The rapid penetration of uncertain and unpredictable renewable energy resources into the power grid has made generation planning and real-time power balancing a challenge, thus rendering demand-side advanced control a necessity. In this paper, we introduce a distributed optimization framework for load flexibility control in the grid. The proposed scheme is based on Newton iteration to provide fast convergence and is scalable to a large number of loads at the aggregation level. The developed optimization framework is based on interior-point methods and concepts of model-predictive control. It uses load-aggregator communications to solve a large-scale optimization problem in a computationally distributed manner without geometric structural assumptions. We demonstrate the performance of the algorithm in a large-scale simulation comprising 10 000 grid-connected heterogeneous assets.
Carfilzomib, Rituximab and Dexamethasone (CaRD) Is Highly Active and Offers a Neuropathy Sparing Approach For Proteasome-Inhibitor Based Therapy In Waldenstrom’s Macroglobulinemia (2013)

Abstract Bortezomib is active in Waldenstrom’s macroglobulinemia (WM) but associated with considerable peripheral neuropathy (PN). The proteasome inhibitor carfilzomib (CFZ) is approved in the USA for relapsed/refractory myeloma. Herein, we examined the efficacy and safety of carfilzomib, rituximab, and dexamethasone (CaRD) in 31 proteasome inhibitor and rituximab naive WM patients with symptomatic disease. Median baseline characteristics: age 61, prior therapies 0 (range 0-1), hematocrit 32.3%, hemoglobin 10.7 g/dL, serum IgM 3375 mg/dL, serum M-protein 2.185 g/dL, B2M 3.6 mg/L, and bone marrow disease involvement 60%. Therapy consisted of IV CFZ 20 mg/m2 (cycle 1) then 36 mg/m2 (cycles 2 and beyond) with IV dexamethasone (dex) 20 mg given on days 1,2,8,9 and rituximab 375 mg/m2 on days 2,9 of each 21-day cycle. Treatment consisted of six induction cycles, then maintenance beginning 8 weeks after induction (given every 8 weeks for eight cycles; consisted of CFZ 36 mg/m2, and IV dex 20 mg on days 1,2 and rituximab 375 mg/m2 on day 2). Patients with IgM level &gt;4000 mg/dL underwent plasmapheresis and/or had rituximab held until IgM &lt;4000 mg/dL to prevent symptomatic IgM flare. Patients received oral acyclovir (400 mg twice daily) and famotidine (20 mg twice daily) as concomitant medications. For all 31 patients, median serum IgM levels and M-protein declined to 749 mg/dL and 0.7 g/dL, respectively (p&lt;0.00001). Median hematocrit and hemoglobin rose to 40.9% and 13.7 g/dL, respectively (p&lt;0.00001). A total of 30 patients concluded induction therapy with bone marrow tumor involvement reduced to a median of 7.5% (p=0.0003). The best overall response rate using criteria adapted from the 3rd International Workshop on WM was 81% (1 CR, 8 VGPR, 12 PR, 4 Minor Responses). With a median follow-up of 8 cycles, 22 patients remain on study, including 20 currently on maintenance therapy. Median time to response (for minor responders or better) was 2.1 months. Grade &gt;2 treatment related toxicities included asymptomatic elevation in lipase (12.9%), dex-related hyperglycemia (6.45%), reversible neutropenia (9.67%), and cardiomyopathy (3.22%). There were no grade 2 or greater PN events. Treatment discontinuation occurred for non-response (n=8), cardiomyopathy in a patient with multiple cardiac risk factors (n=1), and progressive disease (n=1). CaRD is highly active and offers a neuropathy sparing approach for proteasome-inhibitor based therapy in WM. Disclosures: Off Label Use: Carfilzomib is a novel proteasome inhibitor, which offers a neuropathic sparing approach on waldenstrom macroglobulinemia disease when used in a combination therapy with rituximab and dexamethasome.
Construct Validity Testing of a Laparoscopic Surgical Simulator (2006)

The noncamera skills (SK3 to 9) of the LAPMentor surgical simulator can distinguish between laparoscopically naive and ES. SK8 showed the highest level of construct validity, by accurately differentiating among the MS, R/F, ES<30 and ES>30.
Bi-Layer Segmentation of Binocular Stereo Video (2005)

This paper demonstrates the high quality, real-time segmentation techniques. We achieve real-time segmentation of foreground from background layers in stereo video sequences. Automatic separation of layers from colour/contrast or from stereo alone is known to be error-prone. Here, colour, contrast and stereo matching information are fused to infer layers accurately and efficiently. The first algorithm, layered dynamic programming (LDP), solves stereo in an extended 6-state space that represents both foreground/background layers and occluded regions. The stereo-match likelihood is then fused with a contrast-sensitive colour model that is learned on the fly, and stereo disparities are obtained by dynamic programming. The second algorithm, layered graph cut (LGC), does not directly solve stereo. Instead the stereo match likelihood is marginalised over foreground and background hypotheses, and fused with a contrast-sensitive colour model like the one used in LDP. Segmentation is solved efficiently by ternary graph cut. Both algorithms are evaluated with respect to ground truth data and found to have similar performance, substantially better than stereo or colour/contrast alone. However, their characteristics with respect to computational efficiency are rather different. The algorithms are demonstrated in the application of background substitution and shown to give good quality composite video output.
Optimized memory requirements for wavelet-based scalable video codecs (2003)

info:eu-repo/semantics/published
Super Learner Analysis of Electronic Adherence Data Improves Viral Prediction and May Provide Strategies for Selective HIV RNA Monitoring (2015)

Our findings provide initial proof of concept for the potential use of electronic medication adherence data to reduce costs through behavior-driven HIV RNA testing.
Terahertz imaging of large objects with high resolution (2020)

For over 28 years, INO has been developing microbolometer arrays for the infrared and Terahertz (THz) domains. INO’s microbolometer array is the key component of INO’s broadband THz cameras. Using this detector, INO has developed active Terahertz imaging systems ranging from 250 GHz to 750 GHz. See-through THz imaging is particularly well suited for security screening of persons and non-destructive inspection of objects. Materials such as cardboard, plastic, leather and denim are transparent to THz radiation and can provide insights on objects hidden from the naked eye or from infrared cameras. In addition, Terahertz provides high resolution images and is non ionizing. In particular, the frequency range of 150 – 550 GHz is of interest for its properties of see-through imaging that enable a wide variety of potential applications. In this paper, we present images obtained around 400 GHz and 200 GHz (corresponding to wavelengths of 0.76 mm and 1.52 mm). We have chosen these two wavelengths to allow for a wide range of objects and obscuring materials to be tested. The 400 GHz wavelength allows better image resolution, while the 200 GHz provides better penetration through the materials. The THz imaging system can obtain images of objects with dimensions up to 1 meter x 0.75 meter with subcentimeter resolution. To achieve this, we use diffraction-limited imaging optics with high numerical aperture and a microbolometer array detector. For each object, multiple images are acquired that are then stitched together. Each instantaneous image can be seen in real-time during the acquisition and has the same resolution as the global reconstructed image. In the context of an application, the operator does not need to wait until the scan has been completed to identify a hidden object if the size of its features is compatible with the instantaneous field-of-view. When a more global image is required, the reconstructed image shows the features of the whole object under investigation without resolution loss. Images are acquired in two different configurations: transmission and reflection. Each imaging configuration provides different information about the features inside the object as well as its composition. In summary, this paper demonstrates the potential for our THz imaging systems by providing see-through high-resolution THz images of large objects. An analysis of the impact of wavelength and imaging configuration on the image results is also provided.
Integrated photonics on thin-film lithium niobate (2021)

Lithium niobate (LN), an outstanding and versatile material, has influenced our daily life for decades—from enabling high-speed optical communications that form the backbone of the Internet to realizing radio-frequency filtering used in our cell phones. This half-century-old material is currently embracing a revolution in thin-film LN integrated photonics. The successes of manufacturing wafer-scale, high-quality thin films of LN-on-insulator (LNOI) and breakthroughs in nanofabrication techniques have made high-performance integrated nanophotonic components possible. With rapid development in the past few years, some of these thin-film LN devices, such as optical modulators and nonlinear wavelength converters, have already outperformed their legacy counterparts realized in bulk LN crystals. Furthermore, the nanophotonic integration has enabled ultra-low-loss resonators in LN, which has unlocked many novel applications such as optical frequency combs and quantum transducers. In this review, we cover—from basic principles to the state of the art—the diverse aspects of integrated thin-film LN photonics, including the materials, basic passive components, and various active devices based on electro-optics, all-optical nonlinearities, and acousto-optics. We also identify challenges that this platform is currently facing and point out future opportunities. The field of integrated LNOI photonics is advancing rapidly and poised to make critical impacts on a broad range of applications in communication, signal processing, and quantum information.
Reversible and irreversible domainwall contributions to the polarization in CSD prepared Ba1−xPbx(Ti,Mn)O3thin films (1999)

Abstract Ba1−xPbxTiO3 (BPT) as a thin film system has been developed to investigate the ferroelectric properties respectively the different ferroelectric polarization contributions. BPT has been synthesized using CSD based on metal propionates. The films were deposited on platinum coated silicon wafers and annealed at 750°C. The BPT thin films were characterized with X-ray diffraction and SEM.
A Mutually Decoupled Coil System to Improve Sensitivity of Inductively Coupled Communication (2022)

To improve the sensitivity of inductively coupled communication, a mutually decoupled transmitter and receiver coil (MDC) system are proposed in this paper. The proposed communication system is intended to be mounted on the frame of a spectacle and used to communicate through weak inductively coupling with an implant measuring intraocular pressure (IOP). The implant consists of a coil that resonates with a capacitor. The capacitance of this capacitor is designed to change with the IOP, thus leading to a change in the self-resonant frequency of the implant. The transmitter coils excites the implant, while the decoupled receiver coil continuously monitors the self-resonant frequency of the implant. The induced voltage across the receiver coil is used to determine the IOP. Simulation results show that a 1.43% change in the sensor capacitance leads to a one mV change in the voltage induced across the receiver coil.
Application of Multisorbent Traps to Characterization and Quantification of Workplace Exposure Source Terms (1995)

Multisorbent traps have been used for several years to characterize complex atmospheres. Only more recently have multisorbent traps been used for quantitative analysis. The traps provide an effective method for retaining a wide range of airborne Organic contaminants, since these carbonaceous sorbents are relatively hydrophobic, have large surface areas, do not have active functional groups, and have fewer chemical artifacts than other sorbents. Multisorbent traps, which are 76 mm in length and have a 6 mm outside diameter, contain sequentially loaded beds of Carbotrap C, Carbotrap, and Carbosieve SIII, similar to a commercially available trap. The injection port of a gas chromatograph is configured for thermal desorption analysis of the traps via an in-house modification. Currently, multisorbent traps are being used to sample the headspace of underground storage tanks at the Department of Energy`s Hanford site, in Richland, Washington. The analyses are performed by flame ionization or mass spectrometric detection. Target organic analytes include C{sub 6} to C{sub 13} alkanes, nitriles, alkyl ketones, dibutyl butyl phosphonate and tributyl phosphate. Pre-analytical holding times or practical reporting times for many target analytes are at least 84 days under either refrigerated or ambient conditions. Traps are fabricated, conditioned, and spiked with three surrogate standards in the vapor phase prior to shipment to the site. Recovery of the surrogates from the multisorbent traps serve as a statistical process control. Source concentrations of Hanford underground storage tank headspaces range from 0.96 mg/m{sup 3} to 1200 mg/m{sup 3}.
Crystal Structure of a Biosynthetic Sulfo-hirudin Complexed to Thrombin (2007)

The leech-derived anticoagulant hirudin is post-translationally sulfated on tyrosine 63, resulting in a >10-fold increase in its affinity for thrombin. We report the structure of a biosynthetic sulfo-hirudin complexed to thrombin solved to 1.84 Å resolution and show that sulfation is responsible for a salt bridge and an extended hydrogen-bond network that taken together account for the increased affinity of sulfo-hirudin for thrombin. We also identify a divalent cation binding site at the interface between the two subunits of α-thrombin that may modulate the physiological activity of thrombin.
Perinatal outcomes in monoamniotic gestations (2003)

Contrary to previous reports, there is a significant increase in the incidence of perinatal loss beyond 32 weeks among monoamniotic twins, suggesting that delivery after corticosteroid therapy should be strongly considered at this gestational age.