gebhart/patrepeval huggingface dataset:
Improvement of gate oxide reliability for tantalum-gate MOS devices using xenon plasma sputtering technology (1998)

The effects of ion species in the sputtering deposition process on gate oxide reliability have been experimentally investigated. The use of xenon (Xe) plasma instead of argon (Ar) plasma in tantalum (Ta) film sputtering deposition for gate electrode formation makes it possible to improve the gate oxide reliability. The Xe plasma process exhibits 1.5 times higher breakdown field and five times higher 50%-charge-to-breakdown (Q/sub BD/). In the Ta sputtering deposition process on gate oxide, the physical bombardment of energetic inert-gas ion causes the generation of hole trap sites in gate oxide, resulting in the lower gate oxide reliability. A simplified model providing a better understanding of the empirical relation between the gate oxide damage and the inert-gas ion bombardment energy in the gate-Ta sputtering deposition process is also presented.
Ways to move (2020)

You’ve taken that first step to get active which is great! There are lots of different ways to get active - indoors, outdoors, with others, on your own, or even with helpful technology! Choose activities that you enjoy and that fit in with everyday life and you’re more likely to keep going.
Physicochemical and Structural Characteristics of Flours and Starches from Waxy and Nonwaxy Wheats (2002)

ABSTRACT A waxy spring wheat ( Triticum aestivum L.) genotype was fractionated into flour and starch by roller and wet‐milling, respectively. The resultant flour and starch were evaluated for end‐use properties and compared with their counterparts from hard and soft wheats and with commercial waxy and nonwaxy corn ( Zea mays L.) starches. The waxy wheat flour had exceptionally high levels of water absorption and peak viscosity compared with hard or soft wheat flour. The flour formed an intermediate‐strength dough that developed rapidly and was relatively susceptible to mixing. Analysis by differential scanning calorimetry and X‐ray diffractometry showed waxy wheat starch had higher gelatinization temperatures, a greater degree of crystallization, and an absence of an amylose‐lipid complex compared with nonwaxy wheat. Waxy wheat and corn starches showed greater refrigeration and freeze‐thaw stabilities than did nonwaxy starches as demonstrated by syneresis tests. They were also similar in pasting properties, but waxy wheat starch required lower temperature and enthalpy to gelatinize. The results show analogies between waxy wheat and waxy corn starches, but waxy wheat flour was distinct from hard or soft wheat flour in pasting and mixing properties.
Explaining differential effects of medication for opioid use disorder using a novel approach incorporating mediating variables (2020)

A novel approach to mediation analysis shows that much of the difference in medication effectiveness (extended-release naltrexone versus buprenorphine-naloxone) on opioid relapse among non-homeless adults with opioid use disorder appears to be explained by mediators of adherence, illicit opioid use, depressive symptoms and pain.
Evolutionary conservation of cell migration genes: from nematode neurons to vertebrate neural crest (2007)

Because migratory cells in all animals share common properties, we hypothesized that genetic networks involved in cell migration may be conserved between nematodes and vertebrates. To explore this, we performed comparative genomic analysis to identify vertebrate orthologs of genes required for hermaphrodite-specific neuron (HSN) migration in Caenoryhabditis elegans, and then examined their expression and function in the vertebrate neural crest. The results demonstrate high conservation of regulatory components involved in long-range migrations across diverse species. Although the neural crest is a vertebrate innovation, the results suggest that its migratory properties evolved by utilizing programs already present in the common vertebrate-invertebrate ancestor.
Cationic Metallocene Polymerization Catalysts Based on Tetrakis(pentafluorophenyl)borate and Its Derivatives. Probing the Limits of Anion “Noncoordination” via a Synthetic, Solution Dynamic, Structural, and Catalytic Olefin Polymerization Study (1997)

The synthesis and properties of two soluble, weakly coordinating derivatives of the tetrakis(perfluoroaryl)borate anion B(4-C6F4TBS)4- and B(4-C6F4TIPS)4- (TBS = tert-butyldimethylsilyl and TIPS = triisopropylsilyl) are reported. Reaction of the trityl salts of the above anions with a variety of zirconium and thorium L2MMe2 complexes in benzene or toluene affords the cationic ion-paired methyl complexes L2MMe+X- or the corresponding hydrido complexes L2MH+X- (L2 = bis(cyclopentadienyl)- or cyclopentadienylamido-type ligand) when the reaction is carried out under dihydrogen. The solid state structure of the complex (Me5Cp)2ThMe+B(C6F5)4- has been characterized by X-ray diffraction. The B(C6F5)4--based zirconocenium methyl complexes L2MMe+ are unstable at room temperature with respect to, among other factors, intramolecular C−H activation of the ligand framework. In general, the thermal stabilities of the B(C6F4TBS)4-- and B(C6F4TIPS)4--derived complexes are greater than those of the corresponding B(C6F5)4-- and MeB(C6F5)3--derived analogues. The relative coordinative tendencies of MeB(C6F5)3-, B(C6F5)4-, B(C6F4TBS)4-, and B(C6F4TIPS)4- are estimated from the solution spectroscopic information and the structural dynamics of the ion-pairs and follow the order MeB(C6F5)3- > B(C6F4TBS)4- ≈ B(C6F4TIPS)4- > B(C6F5)4-. The coordination of the neutral metallocene precursors to the cationic metallocenes is found to compete with counteranion coordination. Arene solvent coordination to the zirconium constrained geometry cation [(Me4Cp)SiMe2(NtBu)]ZrMe+ is also observed when B(C6F5)4- is the counteranion. (1,2-Me2Cp)2ZrMe+B(C6F4TBS)4- undergoes slow decomposition under an inert atmosphere to afford [(1,2-Me2Cp)2ZrF]2(μ-F)+B(C6F4TBS)4-, which has been characterized by X-ray diffraction. The olefin polymerization activity and thermal stability of the zirconocene catalysts reaches a maximum when B(C6F4TBS)4- and B(C6F4TIPS)4- are used as counteranions. The polymerization activity of the zirconium constrained geometry complex also reaches a maximum in aromatic solvents when B(C6F5)4- is used as the counteranion, apparently due to solvent coordination.
A Deep Learning Model for Automated Classification of Intraoperative Continuous EMG (2020)

This technique has potential to improve surgical safety by reducing cognitive load and inter-rater variability.
Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptorJeffery A. Zablocki, Masateru Miyano, Shashidhar N. Rao, Susan Panzer-Knodle, Nancy Nicholson, and Larry FeigenCite this: J. Med. Chem. 1992, 35, 26, 4914–4917Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/jm00104a019https://doi.org/10.1021/jm00104a019research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Wnt ligand/Frizzled 2 receptor signaling regulates tube shape and branch-point formation in the lung through control of epithelial cell shape (2014)

Changing the morphology of a simple epithelial tube to form a highly ramified branching network requires changes in cell behavior that lead to tissue-wide changes in organ shape. How epithelial cells in branched organs modulate their shape and behavior to promote bending and sculpting of the epithelial sheet is not well understood, and the mechanisms underlying this process remain obscure. We show that the Wnt receptor Frizzled 2 (Fzd2) is required for domain branch formation during the initial establishment of the respiratory tree. Live imaging and transcriptome analysis of lung-branching morphogenesis demonstrate that Fzd2 promotes changes in epithelial cell length and shape. These changes in cell morphology deform the developing epithelial tube to generate and maintain new domain branches. Fzd2 controls branch formation and the shape of the epithelial tube by regulating Rho signaling and by the localization of phospho-myosin light chain 2, in turn controlling the changes in the shape of epithelial cells during morphogenesis. This study demonstrates the importance of Wnt/Fzd2 signaling in promoting and maintaining changes in epithelial cell shape that affect development of a branching network.
Experimental Demonstration of Broadband Silicon 4-Mode (de)Multiplexer Designed by Wavefront-Matching Method (2021)

A broadband silicon-based 4-mode multiplexer designed using a wavefront-matching method is experimentally demonstrated. Measured results strongly correlate with simulated results, and very flat transmission spectra are observed for the proposed device.
Monitoring of Lumbosacral Nerve Roots During Spinal Instrumentation (1993)

A technique is described for intraoperative, multimodality electrophysiologic monitoring of the spinal cord and lumbosacral nerve roots (cauda equina). Simultaneous monitoring with the techniques of electromyography, compound muscle action potentials, and somatosensory evoked potentials is found to provide highly useful information to the surgeon during lumbar spine instrumentations. Compound muscle action potential recordings are used to identify nerve roots in the lumbosacral region, especially when visual identification of the nerve is hindered by scarring or distortion of the anatomy. Electromyography continuously monitors nerve roots at risk by revealing neurotonic discharges when the nerve roots are irritated during surgical dissection or placement of the fixation device. The early warning provided by this technique enables the surgeon to avoid irreversible neurologic damage.
Chemical gastro-oesophagitis, upper gastrointestinal haemorrhage and gastroscopic findings following Dettol poisoning (1995)

1. Dettol liquid (chloroxylenol 4.8%, pine oil, isopropyl alcohol), a household disinfectant, has a corrosive action on the gastrointestinal mucosa when swallowed. The incidence of upper gastrointestinal haemorrhage and gastroscopic findings following Dettol poisoning was studied in 89 patients. 2. Five patients (5.6%) developed minor haematemesis, in the form of coffee-coloured or blood-stained vomitus. One patient had a gastroscopy performed on the day after admission, showing signs of chemical burns in the oesophagus and stomach. Gastroscopy was performed in one other patient on day 11 to rule out oesophageal stricture; the patient was normal. All patients completely recovered. 3. The data from this study suggest that upper gastrointestinal haemorrhage following Dettol poisoning tends to be mild and self-limiting. Gastroscopy, which may increase the risk of aspiration in patients with impaired consciousness, is not required unless other causes of gastrointestinal bleeding are suspected.
Impairment of Preimplantation Porcine Embryo Development by Histone Demethylase KDM5B Knockdown Through Disturbance of Bivalent H3K4me3-H3K27me3 Modifications1 (2015)

KDM5B (JARID1B/PLU1) is a H3K4me2/3 histone demethylase that is implicated in cancer development and proliferation and is also indispensable for embryonic stem cell self-renewal, cell fate, and murine embryonic development. However, little is known about the role of KDM5B during preimplantation embryo development. Here we show that KDM5B is critical to porcine preimplantation development. KDM5B was found to be expressed in a stage-specific manner, consistent with demethylation of H3K4me3, with the highest expression being observed from the 4-cell to the blastocyst stages. Knockdown of KDM5B by morpholino antisense oligonucleotides injection impaired porcine embryo development to the blastocyst stage. The impairment of embryo development might be caused by increased expression of H3K4me3 at the 4-cell and blastocyst stages, which disturbs the balance of bivalent H3K4me3-H3K27me3 modifications at the blastocyst stage. Decreased abundance of H3K27me3 at blastocyst stage activates multiple members of homeobox genes (HOX), which need to be silenced for faithful embryo development. Additionally, the histone demethylase KDM6A was found to be upregulated by knockdown of KDM5B, which indicated it was responsible for the decreased abundance of H3K27me3 at the blastocyst stage. The transcriptional levels of Ten-Eleven Translocation gene family members (TET1, TET2, and TET3) are found to be increased by knockdown of KDM5B, which indicates cross talk between histone modifications and DNA methylation. The studies above indicate that KDM5B is required for porcine embryo development through regulating the balance of bivalent H3K4me3-H3K27me3 modifications.
Miniature fiber facet atomic force microscope using photonic crystal sensors (2014)

A miniaturized Atomic Force Microscope is fabricated on the facet of an optical fiber. Photonic crystal mirrors are integrated into the fabrication creating a Fabry Perot sensor for sensitive force measurements that verify the probe's ability to resolve forces down to 8 pN/Hz <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.5</sup> . This AFM form factor enables a path towards in-vivo, high-bandwidth and non-contact AFM imaging.
Diagnosing from descriptive knowledge bases (2002)

Deals with a diagnostic method using so-called descriptive knowledge bases. It is based on the concept of using a MIMO (multiple-input, multiple output) fuzzy model to represent the information contained in the knowledge base. The model structure and initial parameter values are estimated by applying FMEA (failure mode and effect analysis). Finer parameter estimates are obtained by using a backpropagation learning algorithm. Rules for learning the parameters of a MIMO fuzzy model are derived. An actual diagnostic problem is solved by using an an optimization algorithm for inverting the MIMO fuzzy model.
Supplementary Table 1 from Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth (2023)

Supplementary Table 1 from Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth
Fundamental Subspaces of S (2006)

In the last chapter we discussed the elementary topological properties of the network that the stoichiometric matrix represents. In this chapter we look deeper into the properties of the stoichiometric matrix and how these fundamental topological properties can be used to obtain a more thorough understanding of the reaction network that it represents. This material is perhaps the most mathematical part of this book. It should be readily accessible to readers with formal education in the physical and engineering sciences, while readers with a life science background may find it challenging. The concepts introduced are important to the rest of the chapters in Part II. The stoichiometric matrix is a mathematical mapping operation (recall Figure 6.1). Matrices have certain fundamental properties that describe this mapping operation. These properties are contained in the four fundamental subspaces associated with a matrix. This chapter discusses these subspaces and how we can mathematically define them and interpret their contents in biochemical and biological terms.
Solving Mazes Using Microfluidic Networks (2003)

This work demonstrates that pressure-driven flow in a microfluidic network can solve mazelike problems by exploring all possible solutions in a parallel fashion. Microfluidic networks can be fabricated easily by soft lithography and rapid prototyping. To find the best path between the inlet and the outlet of these networks, the channels are filled with a fluid, and the path of a second, dyed fluid moving under pressure-driven flow is traced from the inlet to the outlet. Varying the viscosities of these fluids allows the behavior of the system to be tailored. For example, filling the channels with immiscible fluids of different viscosities enhances the resolution of paths of different fluidic resistances.
Sequence‐specific potentiation of topoisomerase II inhibitors by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (2004)

Acetylation of histones leads to conformational changes of DNA. We have previously shown that the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), induced cell cycle arrest, differentiation, and apoptosis. In addition to their antitumor effects as single agents, HDAC inhibitors may cause conformational changes in the chromatin, rendering the DNA more vulnerable to DNA damaging agents. We examined the effects of SAHA on cell death induced by topo II inhibitors in breast cancer cell lines. Topo II inhibitors stabilize the topo II-DNA complex, resulting in DNA damage. Treatment of cells with SAHA promoted chromatin decondensation associated with increased nuclear concentration and DNA binding of the topo II inhibitor and subsequent potentiation of DNA damage. While SAHA-induced histone hyperacetylation occurred as early as 4 h, chromatin decondensation was most profound at 48 h. SAHA-induced potentiation of topo II inhibitors was sequence-specific. Pre-exposure of cells to SAHA for 48 h was synergistic, whereas shorter pre-exposure periods abrogated synergy and exposure of cells to SAHA after the topo II inhibitor resulted in antagonistic effects. Synergy was not observed in cells with depleted topo II levels. These effects were not limited to specific types of topo II inhibitors. We propose that SAHA significantly potentiates the DNA damage induced by topo II inhibitors; however, synergy is dependent on the sequence of drug administration and the expression of the target. These findings may impact the clinical development of combining HDAC inhibitors with DNA damaging agents.
Using partial reconfiguration and high-level models to accelerate FPGA design validation (2010)

Design validation is the most time-consuming task in the FPGA design cycle. Although manufacturers and third-party vendors offer a range of tools that provide different perspectives of a design, many require that the design be fully re-implemented for parameter modifications or do not allow the design to be run at full-speed. Designs are frequently first modeled using a high-level language then later rewritten in a hardware description language, first for simulation and then later modified for synthesis. IP and third-party cores may differ during these final two stages complicating development and validation. Our approach provides a means of directly validating synthesized hardware designs with the original high-level model, abstracting away the traditional bit-level view of designs. The Dynamic Modular Development (DMD) framework accelerates module turnaround by reusing floorplans and placing frequently changing modules into separate, partially reconfigurable regions. The debug framework also leverages these reconfigurable regions to accelerate the modification of dynamic, software-like breakpoints for low-level analysis.
Beyond Conventional Security in Sponge-Based Authenticated Encryption Modes (2018)

The Sponge function is known to achieve $$2^{c/2}$$ security, where c is its capacity. This bound was carried over to its keyed variants, such as SpongeWrap, to achieve a $$\min \{2^{c/2},2^\kappa \}$$ security bound, with $$\kappa $$ the key length. Similarly, many CAESAR competition submissions were designed to comply with the classical $$2^{c/2}$$ security bound. We show that Sponge-based constructions for authenticated encryption can achieve the significantly higher bound of $$\min \{2^{b/2},2^c,2^\kappa \}$$ , with $$b>c$$ the permutation size, by proving that the CAESAR submission NORX achieves this bound. The proof relies on rigorous computation of multi-collision probabilities, which may be of independent interest. We additionally derive a generic attack based on multi-collisions that matches the bound. We show how to apply the proof to five other Sponge-based CAESAR submissions: Ascon, CBEAM/STRIBOB, ICEPOLE, Keyak, and two out of the three PRIMATEs. A direct application of the result shows that the parameter choices of some of these submissions are overly conservative. Simple tweaks render the schemes considerably more efficient without sacrificing security. We finally consider the remaining one of the three PRIMATEs, APE, and derive a blockwise adaptive attack in the nonce-respecting setting with complexity $$2^{c/2}$$ , therewith demonstrating that the techniques cannot be applied to APE.
Exploration of the Mitsunobu Reaction with Tosyl- and Boc-Hydrazones as Nucleophilic Agents (2006)

Tosyl- and Boc-hydrazones were found to be effective nucleophiles in the Mitsunobu reaction. Tosyl hydrazones reacted cleanly with primary and secondary alcohols when co-administered to a cooled DBAD/PPh3 or DEAD/PPh3 complex. Boc-hydrazones required electron-withdrawing substituents to participate in the reaction.
Oxygen Permeation of a Dense/Porous Asymmetric Membrane Using La0.6Ca0.4CoO3−δ–BaFe0.975Zr0.025O3−δ System (2008)

Abstract To achieve a high oxygen permeation rate at medium and high temperature, an asymmetrically structured membrane, in which a thin dense layer (30 μm) made of La0.6Ca0.4CoO3−δ (LCC) and BaFe0.975Zr0.025O3−δ (BFZ) was formed on a porous LCC support, was fabricated and tested for its oxygen permeability. The oxygen permeation flux significantly increased by mixing BFZ with LCC and reached a fairly high value of 1.60 cm3 min−1 cm−2 even at 780 °C.
NOTICES (1971)

Journal Article NOTICES Get access THE SOCIOLOGY OF SUBCULTURES. Edited by DAVID O. ARNOLD. [Berkeley: The Glendessary Press. 1970. v and 171 pp. paperback. No price stated.] Stanley Cohen Stanley Cohen Search for other works by this author on: Oxford Academic Google Scholar The British Journal of Criminology, Volume 11, Issue 1, January 1971, Pages 97–98, https://doi.org/10.1093/oxfordjournals.bjc.a046289 Published: 01 January 1971
Study of Plasma on the GOL-3 Facility by Imaging VUV Spectroscopy (2011)

The series of experiments on plasma heating by the electron beam of reduced diameter was carried out at the GOL-3 facility. To define the size of a high-temperature plasma region the imaging VUV spectrometer was used in these experiments. In the paper the description of the diagnostic system, the results of measurements, the comparison with simulation data of the ionization balance are presented. Estimations of transverse diffusion and macroscopic movements of the beam are discussed.