gebhart/patrepeval huggingface dataset:
Simulation-Assisted, Weather-Aware Urban Air Mobility System Planning (2023)

The emergence of Urban Air Mobility (UAM) as a novel mode of transportation presents new challenges to government and commercial stakeholders: new vehicle types are being introduced for which supporting infrastructure, such as new routes and vertiports, needs to be designed and put in place, often in the vicinity of airports; community concerns need to be addressed; and inclement weather is a potential disruptive factor. In this new UAM paradigm, simulation modeling is an indispensable tool for aviation planners in identifying optimal solutions to these challenges. AvMet and Kimley-Horn have developed an efficient process for UAM simulation study planning and execution, facilitating rapid turnaround through collaborative model development. This streamlined process, from UAM airspace design and flight schedule development to fast-time simulation modeling, to advanced 3D visualization, can greatly reduce the study completion time and allow for a variety of UAM scenario alternatives to be explored, evaluated from a cost-benefit perspective, and presented to stakeholders. A key component of this process is AvMet's state-of-the-art UAM Simulation Model (USM). In this paper, we provide UAM scenario setup examples and simulation results utilizing the USM, as well as describing the study planning and modeling process.
Metal-free anionic polymerization of methyl methacrylate (1998)

Results on the metal-free anionic polymerization of methyl methacrylate (MMA) are presented. MMA was polymerized in tetrahydrofuran, using tetrabutylammonium diethyl 2-ethylmalonate and tetrabutylammonium 2-nitropropanate as initiators. Immediate polymerization was observed only in cases where the initators did not contain traces of their precursor molecules, the presence of which causes an appreciable inhibition period. This is attributed to the transfer reaction between active species and the precursor molecules. Only after their consumption can the major polymerization start. Using very pure initiators, no inhibition period was observed. Curves from dilatometric measurements showed the existence of an induction period. As usual, this is attributed to an initiation reaction which is slower than the propagation reaction. It is more clearly marked for tetrabutylammonium diethyl 2-ethylmalonate than for tetrabutylammonium 2-nitropropanate as initiator. All polymerizations of MMA usually go to complete consumption of the monomer. However, termination reactions have to be taken into account as well. The well-known intramolecular cyclization reaction was not observed in the MMA system. Here, a Hofmann elimination reaction terminates the growing of chains, which is due to the butyl ligands of the ammonium cation, where a β-hydrogen atom can be transferred to the growing chain under the formation of tri-n-butylamine and 1-butene. To eliminate this termination step, tetramethylammonium diethyl 2-ethylmalonate was synthesized and used as the initiator for the polymerization of MMA. Now transalkylation under the formation of a methyl group terminated the saturated chain end and trimethyl amine could be detected as a second termination reaction. Neither of the termination reactions seems to be very fast. The molecular weight distributions of the synthesized polymers are relatively broad.
6. COMPARISON OF IMAGING PROPERTIES OF A COMPUTED RADIOGRAPHY SYSTEM AND SCREEN-FILM SYSTEMS EVALUATED IN THE UNIVERSITY OF CHICAGO (1991)

(1)種々のサイズのIPにおけるプリサンプリングMTFは低空間周波数領域では同様であった.高空間周波数領域では, サイズが小さいもの程, プリサンプリングMTFは向上した.(2)CR画像のプリサンプリングMTFはスクリーン/フィルム系のMTFに比べて, 低空間周波数領域で大きかったが高空間周波数領域では低い値を示した.(3)二画像同時撮影法で得られたCR画像とそうでないCR画像のプリサンプリングMTFはほぼ同様であった.(4)CR画像のウィナースペクトルはスクリーン/フィルム系のそれに比べて, 約2倍, 二画像同時撮影法を用いたときで約3倍程度大きな値を示した.(5)CR画像の出力画像が縮小されると, そのウィナースペクトルはスクリーン/フィルム系のそれと, 見かけ上だけは, ほぼ同等またはそれ以下の値を示した.しかし, CR画像は, 本質的にスクリーン/フィルム系よりも粒状の多いシステムである.(6)各種試験彼写体を撮影したCR画像ではノイズがその画質を低下させているのが明かに認識できた.(7)患者胸部のCR画像の画質はスクリーン/フィルム系のそれと大体において等価と考えられた.(8)二画像同時撮影法はCR画像の診断能をスクリーン/フィルム系のそれと比較検討するために有用な手法である.今後さらに, 二画像同時撮影法を用いて症例を増やして検討を続け, 十分な数の症例を用いてオブザーバーテストを行う予定である.
Quantitative Knee Arthrography in a Large Animal Model of Osteoarthritis Using Photon-Counting Detector CT (2020)

We demonstrated a high-resolution and quantitative PCD-CT arthrography technique for grading cartilage damage in a large animal model of osteoarthritis. Photon-counting detector CT offers simultaneous high-resolution and multienergy imaging capabilities that allowed morphological assessment of cartilage loss and quantification of contrast levels in the joint as a marker of joint disease. Cartilage damage in the MIA knees was graded using PCD-CT images, and the image-based findings were further confirmed using histology and gross examination of the excised knees.
Farnesyl Protein Transferase Inhibitor ZARNESTRA&#8482; R115777 - History of a Discovery (2003)

R115777 (R)-6-amino[(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone is a potent and selective inhibitor of farnesyl protein transferase with significant antitumor effects in vivo subsequent to oral administration in mice. Taking its roots into Janssen's ketoconazole and retinoic acid catabolism programs, our interest into Ras prenylation process led us stepwise to identify the key structural features of R115777. Methodology, structure activity relationships, and pharmacology will be presented. R115777 is currently in phase III clinical evaluation.
Yersinia enterocolitica Provides the Link between Thyroid-Stimulating Antibodies and Their Germline Counterparts in Graves’ Disease (2013)

Graves' disease results from thyroid-stimulating Abs (TSAbs) activating the thyrotropin receptor (TSHR). How TSAbs arise from early precursor B cells has not been established. Genetic and environmental factors may contribute to pathogenesis, including the bacterium Yersinia enterocolitica. We developed two pathogenic monoclonal TSAbs from a single experimental mouse undergoing Graves' disease, which shared the same H and L chain germline gene rearrangements and then diversified by numerous somatic hypermutations. To address the Ag specificity of the shared germline precursor of the monoclonal TSAbs, we prepared rFab germline, which showed negligible binding to TSHR, indicating importance of somatic hypermutation in acquiring TSAb activity. Using rFab chimeras, we demonstrate the dominant role of the H chain V region in TSHR recognition. The role of microbial Ags was tested with Y. enterocolitica proteins. The monoclonal TSAbs recognize 37-kDa envelope proteins, also recognized by rFab germline. MALDI-TOF identified the proteins as outer membrane porin (Omp) A and OmpC. Using recombinant OmpA, OmpC, and related OmpF, we demonstrate cross-reactivity of monoclonal TSAbs with the heterogeneous porins. Importantly, rFab germline binds recombinant OmpA, OmpC, and OmpF confirming reactivity with Y. enterocolitica. A human monoclonal TSAb, M22 with similar properties to murine TSAbs, also binds recombinant porins, showing cross-reactivity of a spontaneously arising pathogenic Ab with Y. enterocolitica. The data provide a mechanistic framework for molecular mimicry in Graves' disease, where early precursor B cells are expanded by Y. enterocolitica porins to undergo somatic hypermutation to acquire a cross-reactive pathogenic response to TSHR.
Large-Scale Preparation of Extracellular Vesicles Enriched with Specific microRNA (2018)

This article describes a method for producing microRNA (miRNA)-enriched extracellular vesicles in large quantities. It enables in vivo delivery of specific miRNA for therapeutic applications.
Isotropic Surface Remeshing (2003)

This paper proposes a new method for isotropic remeshing of triangulated surface meshes. Given a triangulated surface mesh to be resampled and a user-specified density function defined over it, we first distribute the desired number of samples by generalizing error diffusion, commonly used in image halftoning, to work directly on mesh triangles and feature edges. We then use the resulting sampling as an initial configuration for building a weighted centroidal Voronoi tessellation in a conformal parameter space, where the specified density function is used for weighting. We finally create the mesh by lifting the corresponding constrained Delaunay triangulation from parameter space. A precise control over the sampling is obtained through a flexible design of the density function, the latter being possibly low-pass filtered to obtain a smoother gradation. We demonstrate the versatility of our approach through various remeshing examples.
An empirical approach for modeling fuzzy geographical descriptors (2017)

We present a novel heuristic approach that defines fuzzy geographical descriptors using data gathered from a survey with human subjects. The participants were asked to provide graphical interpretations of the descriptors `north' and `south' for the Galician region (Spain). Based on these interpretations, our approach builds fuzzy descriptors that are able to compute membership degrees for geographical locations. We evaluated our approach in terms of efficiency and precision. The fuzzy descriptors are meant to be used as the cornerstones of a geographical referring expression generation algorithm that is able to linguistically characterize geographical locations and regions. This work is also part of a general research effort that intends to establish a methodology which reunites the empirical studies traditionally practiced in data-to-text and the use of fuzzy sets to model imprecision and vagueness in words and expressions for text generation purposes.
High-resolution imaging of coronary atherosclerosis by optical coherence tomography (2004)

We describe a recent intracoronary optical coherence tomography study conducted in a cohort of 80 patients. Our results demonstrate that optical coherence tomography holds great potential for identifying high-risk coronary plaques.
Home network infrastructure for handheld/wearable appliances (2002)

A server infrastructure allows wireless wearable appliances or portable handsets to access consumer services offered via the server. Services are accessed via a universal home services interface (UHSI) which is shared by all access devices. The UHSI can include a voice-activated interface to simplify usage from non-graphical terminals. In a home network, the infrastructure resides on a home gateway or central home computer and allows users access to local subsystems or external WAN services. An implementation based on a universal plug and play (UPnP) home network is described.
Failure to Propagate Cryptosporidium spp. in Cell-Free Culture (2006)

The successful propagation of Cryptosporidium parvum in cell-free culture medium was recently reported. To investigate whether this phenomenon could be broadened to include other C. parvum isolates, as well as Cryptosporidium hominis, we attempted to propagate 3 isolates in cell-free medium under reported culture conditions. Cryptosporidium oocysts from C. parvum strains Moredun (MD) or IOWA or C. hominis strain TU502 were added to media containing coagulated newborn calf serum. The cultures were sampled at various times throughout a 45 (IOWA) or 78 (MD, TU502)-day period and were microscopically examined for various life stages of Cryptosporidium. Cell-free cultures harvested on days 45 and 68 postinoculation were tested for in vitro infectivity on Madrin-Darby bovine kidney cells. In vivo infectivity testing was performed using either infant or 2-wk-old immunosuppressed C57BL mice with cell-free cultures harvested on days 52 and 78. Fecal and gut samples collected from mice were examined by modified acid-fast staining. Data from wet mounts, electron microscopy, and in vitro and in vivo infectivity testing showed that the original oocysts did not complete their life cycle and produce new, viable, infectious oocysts in cell-free culture. Thus, we conclude that this is not a universal phenomenon or readily accomplished.
Variable-Forgetting Factor Rls For Stereophonic Acoustic Echo Cancellation With Widely Linear Model (2012)

Publication in the conference proceedings of EUSIPCO, Bucharest, Romania, 2012
Headpiece domain of dematin is required for the stability of the erythrocyte membrane (2002)

Dematin is an actin-binding and bundling protein of the erythrocyte membrane skeleton. Dematin is localized to the spectrin-actin junctions, and its actin-bundling activity is regulated by phosphorylation of cAMP-dependent protein kinase. The carboxyl terminus of dematin is homologous to the "headpiece" domain of villin, an actin-bundling protein of the microvillus cytoskeleton. The headpiece domain contains an actin-binding site, a cAMP-kinase phosphorylation site, plays an essential role in dematin self-assembly, and bundles F-actin in vitro. By using homologous recombination in mouse embryonic stem cells, the headpiece domain of dematin was deleted to evaluate its function in vivo. Dematin headpiece null mice were viable and born at the expected Mendelian ratio. Hematological evaluation revealed evidence of compensated anemia and spherocytosis in the dematin headpiece null mice. The headpiece null erythrocytes were osmotically fragile, and ektacytometry/micropore filtration measurements demonstrated reduced deformability and filterability. In vitro membrane stability measurements indicated significantly greater membrane fragmentation of the dematin headpiece null erythrocytes. Finally, biochemical characterization, including the vesicle/cytoskeleton dissociation, spectrin self-association, and chemical crosslinking measurements, revealed a weakened membrane skeleton evidenced by reduced association of spectrin and actin to the plasma membrane. Together, these results provide evidence for the physiological significance of dematin and demonstrate a role for the headpiece domain in the maintenance of structural integrity and mechanical properties of erythrocytes in vivo.
Synthesis of peptide sequences related to thrombospondin: factors affecting aspartimide by‐product formation (2003)

Aspartimide formation is one of the most common secondary reactions on solid phase peptide synthesis. In the present work, we describe the optimization of the synthesis of two thrombospondin fragments containing an Asp-Gly sequence that show a strong tendency to form cyclic aspartimide derivatives in an unusual high percentage. Several different strategies were applied changing type of resin, Fmoc-deprotection reagents, coupling additives, resin cleavage cocktails and the use of Hmb-Gly derivative to minimize the extension of this byproduct. Best results were obtained with cross-linked ethoxylate acrylate (CLEAR-cross-linked ethoxylate Acrylate Resin)-type resin and pip/dimethylformamide deprotection. Besides, as in biological assays the aspartimide containing sequence resulted to be more active than the linear one, the optimization of its synthesis was also carried out.
Temperature variable supply voltage for power reduction (2003)

The scaling trend of MOSFETs requires the supply and the threshold voltages to be reduced in future generations. Although the supply voltage is reduced, the total power dissipation and the static power of the chip are increased. Power dissipation is one of the limiting factors in achieving the highest performance of a chip. Therefore, new power reduction techniques are required. In this paper a new technique is introduced to reduce the power consumption. In this technique the supply voltage is changed dynamically as temperature changes. Using this technique, for 70 nm devices the total power consumption of the chip can be reduced by 24% and the static power can be reduced by 40%. This reduction is achieved without any change in the worst-case delay.
Megawatt-Class Pulsed Helicon (2018)

Eagle Harbor Technologies, Inc. (EHT) is developing a megawatt-class helicon plasma source for testing a repetitively pulsed, high power RF system for plasma heating. EHT is using the previously developed high frequency full-bridge to drive a series resonant load, which enables the high-power operation. This plasma is being characterized with a swept Langmuir probe. We will present plasma density and electron temperature results over a range of neutral pressures, magnetic field strengths, and input power levels.
Effect of High Energy Electron Irradiation on Electrical and Noise Properties of 4H-SiC Schottky Diodes (2018)

Electron irradiation of high voltage Ni/4H-SiC Schottky diodes with the dose Φ = (0.2-7)×10 16 cm -2 led to increase in the base resistance, appearance of slow relaxation processes at extremely small currents, and increase of the low frequency noise. On exponential part of the current-voltage characteristics and on linear part of current-voltage characteristics in non-irradiated samples, low frequency noise always has the form of the 1/f noise. On linear part of the current-voltage characteristics in irradiated diodes the generation recombination (GR) noise predominates. Temperature dependences of the base resistivity and character of GR noise indicate that mainly Z 1/2 center contributes to the change in the parameters of irradiated samples. Capture cross section of this level, obtained from noise measurements, is within the range (8×10 -16 -2×10 -15 ) cm 2 and only weakly depends on temperature.
Poster session 1 (2012)

Abstract P 79 Frontiers in CardioVascular Biology, London 30th March – 1st April 2012 Second Congress of the ESC Council on Basic Cardiovascular Science.
Converting tumors into vaccine manufacturing factories: DC recruitment, activation and clinical responses with a flt3L-primed in situ vaccine for low-grade lymphoma [nct01976585] (2014)

Meeting abstracts Lymphomas are the 5th most common cancer in the U.S. and the most prevalent amongst these, low-grade B cell lymphomas are incurable with standard therapy. Previously, we completed three trials combining low-dose radiotherapy (XRT) with intratumoral administration of a TLR9 agonist
Effect Of Exercise On Reserve Of Repolarization And Blood Stress Markers (2019)

Reserve of repolarization of the heart (RoR) is a non-invasive method to monitor the heart’s response to stress. RoR assess stability of cardiac membranes and when excitation becomes unstable. Previous studies reported RoR as a useful tool to determine cardiac risk in cardiac patients. In this study we compared two cohort groups, posttraumatic stress disorder (PTSD) which has a strong association with CVD and a group of apparently healthy subjects (AH). PURPOSE: To determine if RoR and blood stress markers in AH and PTSD cohorts are different at rest and in response to a graded exercise test to 85% HRmax. METHODS: Ten young women with documented PTSD (23.2 ± 1.4 yrs.) and 8 AH individuals (24.1 ± 1.7 yrs) with normal BP arrived after overnight fast (7-9 am) and rested for 20 minutes. ECG’s (12 lead) were monitored before, during and after exercise to obtain RoR. Blood was taken at rest and after exercise. Plasma samples were analyzed for stress proteins. RESULTS: Resting HR’s were statistically higher in the PTSD group compared to AH group (77.2 ±3.1; 67.7±2.6 bpm, P < 0.0001). Resting RoR between groups was not significantly different (AH=81±7%, PTSD = 78±5%, P > 0.2). RoR at the final exercise stage in AH group had significantly greater reserve (RoR = 40.4% compared to PTSD = 32.6%, P = 0.02) despite greater workload. Brain natriuretic peptide (BNP) increased in PTSD (pre =139.8 ±27.8, post = 232.8±47.8 pg/ml, P = 0.02) whereas AH showed no change (pre =123.9 ±30.2, post = 138±44.2 pg/ml). Plasma TnI was not different between groups at rest (P > 0.3) but increased significantly (P = 0.03) only in PTSD group with no changes in blood creatine kinase between groups and across time. CONCLUSIONS: These data suggest that PTSD individuals have less RoR in response to graded exercise compared to AH individuals. In addition, PTSD group had increased plasma BNP, and TNI suggesting an increased risk of having a cardiac event. It is suggested that this procedure may be useful as a screening process to help identify individuals with a risk of a coronary event.
1543: A MODEL OF LONG-TERM INTENSIVE SUPPORTIVE CARE IN NONHUMAN PRIMATES (2017)

Connelly, Mark; Kindrachuk, Jason; Herbert, Richard; Swerczek, Joanna; Jacobson, Eliana; Chertow, Daniel Author Information
Tetraarylphosphonium Salts as Soluble Supports for the Synthesis of Small Molecules (2007)

Gesteuerte Löslichkeit: Phosphoniumsalze können bei der Synthese von niedermolekularen Verbindungen und von Peptiden als Gruppen zur Steuerung der Löslichkeit (SCGs) eingesetzt werden (siehe Schema). Das Konzept, eine Kombination aus Synthese in Lösung und Festphasensynthese, wird verdeutlicht durch die Herstellung 2-substituierter Piperidinderivate und einer Reihe kleiner Peptide in hohen Ausbeuten und Reinheiten. In einigen Fällen ließ sich das Trägermaterial zurückgewinnen. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2007/z700833_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Introducing carbon nanotubes into living walled plant cells through cellulase-induced nanoholes (2011)

Carbon nanotubes can intracellularly transport through different cellular barriers. However, their use in plant cells is limited by the cellulosic cell wall surrounding these cells. Here we show that cup-stacked carbon nanotubes with cellulase immobilized on their sidewalls and tips penetrate the cell wall and transport intracellularly through cellulase-induce nanoholes.
Identification and Validation of Anaphylaxis Using Electronic Health Data in a Population-based Setting (2021)

In this population-based setting, ICD-10 diagnosis codes for anaphylaxis from emergency department and inpatient settings had moderate PPV and sensitivity for validated events. These findings have implications for epidemiologic studies that seek to estimate risks of anaphylaxis using electronic health data.
Differentiation and tumor response to retinobenzoic acid RE-80 in a malignant conversion model. (1995)

The synthetic retinobenzoic acid RE-80 was evaluated for its potential as an inductor of tumor cell differentiation and as a chemopreventive agent. A minimally toxic dose of RE-80 in vitro produced morphologic changes typical differentiation in epidermal tumor cell colonies. Indirect immunofluorescence indicated induction of a differentiation-associated keratin of internal stratified epithelia, K13, and inhibition of the differentiation-associated epidermal keratin K1. Cultured cells were skin-grafted to athymic nu/nu mice to evaluate RE-80 effects on early stage malignant progression in vivo. When tumors had grown to 3 to 4 mm in diameter, mice were treated by intraperitoneal injection with RE-80 (67 micrograms, 170 mmol, i.p., two times per week) or vehicle (100 microliters 20% ethanol). Papillomas (benign) and moderately differentiated squamous cell carcinomas were reduced in volume about 4-fold by RE-80 treatment. Larger, poorly differentiated squamous cell carcinomas were unaffected. RE-80 resulted in a lower proportion of proliferative cells (detectable by bromodeoxyuridine incorporation) and a higher proportion of moderately to well differentiated tumors after 40 days of treatment compared with control tumors, which were mainly poorly differentiated squamous cell carcinomas. K13 induction in vitro was correlated with response to retinoid in vivo. Induction of differentiation may be mechanism of the response to RE-80 in vivo since carcinoma cells expressing K13 did not incorporate bromodeoxyuridine and were on a terminal pathway.