gebhart/patrepeval huggingface dataset:
Abstract 3248: PSMA specific imaging of prostate cancer (2010)

Abstract A peptide derivative of a prostate specific membrane antigen (PSMA) targeting ligand [Glu-C(O)-Glu] was designed to efficiently coordinate 99mTc. This chelate, referred to as EC0652, was found to bind cultured PSMA-positive LNCaP tumor cells in a concentration-dependent manner with very high affinity (Kd ∼ 20 nM). Its binding was reduced &amp;gt; 10 fold in the presence of the ligand competitor PMPA (a high affinity PSMA binder). In addition, this molecule did not bind to panel of PSMA negative cells (4T1, A549, IGR-OV1, J6456, KB, L1210 and M109), thereby demonstrating the agent's PSMA-specific binding property. Following intravenous injection into nu/nu mice, 99mTc-EC0652 was rapidly cleared from circulation (and non-targeted tissues), and only 1.3% of the injected dose remained in the blood after 1 hour. Data from quantitative biodistribution studies confirmed that 99mTc-EC0652 predominantly accumulates in PSMA-positive subcutaneous LNCaP tumor and kidney (PSMA/glutamate carboxypeptidase positive) tissues. Net uptake in the tumor and kidney remained steady throughout the 8 h experiment resulting in a continued increase in tumor to background tissue radioactivity with time. Radioactive uptake in both of these tissues was reduced &amp;gt; 10 fold when this radiodiagnostic imaging agent was co-dosed with PMPA. The safety of decayed 99mTc-EC0652 was evaluated as a single intravenous dose in an acute toxicology study in male mice. All doses tested were well tolerated with no demonstrated toxicity. The study established a no observed adverse effect level (NOAEL) of 14.0 mg/kg, a dose which provides an appropriate safety margin relative to the FDA designated Phase 0 dose. Equipped with these encouraging results, preparations have begun for a Phase 0 clinical trial to evaluate 99mTc-EC0652 distribution in patients with metastatic prostate cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3248.
Anti-human immunodeficiency virus type-1 (HIV-1) and anti-hepatitis B virus (HBV) activities of (2,3-dideoxy-2-fluoro-β-L-threo-pentofuranosyl)nucleosides (1995)

1-or-9-(2,3-Dideoxy-2-fluoro-β-L-threo-pentofuranosyl)- cytosine (F-β-L-ara-ddC) and-adenine (F-β-L-ara-ddA) were synthesized and their anti-HIV and anti-HBV activities were evaluated.
How to improve your network performance by asking your provider for worse service (2013)

TCP's congestion control is deliberately "cautious", avoiding overloads by starting with a small initial window and then iteratively ramping up. As a result, it often takes flows several round-trip times to fully utilize the available bandwidth. In this paper we propose using several levels of lower priority service and a modified TCP behavior to achieve significantly improved flow completion times while preserving fairness.
Young Scientist Forum (2010)

Univ Sao Paulo, Inst Biol Sci, Dept Microbiol, Sao Paulo, SP, Brazil
<title>Ensemble quantum computing by NMR spectroscopy: product operators, pseudopure states, and an implementation of quantum error correction</title> (1998)

Quantum computers are able to operate on coherent superpositions of states, and to isolate a single global property of the set of computed quantities via interference. In principle, this permits them to solve certain problems exponentially faster thana classical computer, but not one has yet succeeded in implementing a true quantum computer on more than two quantum bits. Recently, however, it has been found that an ensemble of independent and identical quantum computers can perform mots of the same feats than a single quantum computer could, while at the same time bringing massive classical parallelism to bear on its computations. Such an ensemble quantum computer can be realized, to a limited extent, by nuclear magnetic resonance (NMR) spectroscopy on ordinary liquids at room temperature and pressure. This simple implementation depends on special kinds of mixed states, called pseudo-pure states, whose preparation entails a loss of signal that is exponential in the number of spins. While this would appear to limit such an implementation to ca. 8-10 spins in the foreseeable future, NMR spectroscopy has now permitted the first experimental demonstrations of all the basic features of quantum computing. We claim, moreover, that the product operator formalism, on which the theory of NM R spectroscopy is based, provides an efficient framework within which to analyze algorithms and decoherence effects in quantum computing more generally. This is illustrated by presenting our recent experimentally implementation of a quantum error correcting code.
Octahedral nickel(II) complexes of some cyclic polyfunctional thioethers (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOctahedral nickel(II) complexes of some cyclic polyfunctional thioethersWilliam Rosen and Daryle H. BuschCite this: Inorg. Chem. 1970, 9, 2, 262–265Publication Date (Print):February 1, 1970Publication History Published online1 May 2002Published inissue 1 February 1970https://pubs.acs.org/doi/10.1021/ic50084a015https://doi.org/10.1021/ic50084a015research-articleACS PublicationsRequest reuse permissionsArticle Views246Altmetric-Citations81LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Insulin Sensitivity of Suppression of Endogenous Glucose Production Is the Single Most Important Determinant of Glucose Tolerance (2001)

Hyperglycemia results from an imbalance between endocrine pancreatic function and hepatic and extrahepatic insulin sensitivity. We studied 57 well-matched Swedish men with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), or mild diabetes. Oral glucose tolerance and insulin release were assessed during an oral glucose tolerance test (OGTT). Insulin sensitivity and glucose turnover were determined during a two-step euglycemic insulin clamp (infusion 0.25 and 1.0 mU. kg(-1). min(-1)). High-performance liquid chromatography-purified [6-(3)H]glucose was used as a tracer. During low-insulin infusion, the rate of endogenous glucose production (EGP) decreased more in subjects with NGT than in subjects with IGT or diabetes (delta rate of appearance [R(a)] 1.25 +/- 0.10 vs. 0.75 +/- 0.14 vs. 0.58 +/- 0.09 mg. kg(-1). min(-1), P < 0.001). The corresponding rates of glucose infusion during the high-dose insulin infusion (M values) were 8.3 +/- 0.6 vs. 5.4 +/- 0.9 vs. 4.7 +/- 0.4 mg. kg(-1). min(-1) (P < 0.001). A total of 56% of the variation in glucose area under the curve (AUC) during OGTT (glucose AUC) was mainly explained by delta R(a) (increase in multiple R(2) 0.42) but also by delta R(d) (rate of disappearance) (increase in multiple R(2) 0.05), and the early insulin response during OGTT contributed significantly (increase in multiple R(2) 0.07). When M value was included in the model, reflecting extrahepatic insulin sensitivity, it contributed to 20% of the variation in glucose AUC, and together with the incremental insulin response (increase in multiple R(2) 0.21), it explained 45% of the variation. In conclusion, insulin sensitivity of suppression of EGP plays the most important role in the determination of blood glucose response during OGTT.
Hydrajet-Based Fracturing Treatment in Unconventional Wells (2019)

Abstract The success of resource shale development has drawn much attention to develop new technologies to economize the extensive fracturing treatments required to make commercial wells. While a single planar hydraulic fracture is the objective in conventional wells, generating a complex fracturing network is commonly the goal when fracturing unconventional wells. Therefore, in shale formations, it is required to establish connectivity to natural fractures and beddings to generate large Stimulated Reservoir Volume (SRV). Two main staged fracturing techniques have been implemented to complete horizontal wells drilled in the challenging unconventional reservoirs: plug-and-perf and sliding sleeves. This paper presents a technique for effective fracture stimulation, including hydrajetting for fracture initiation, then continuous injection for fracture propagation. Hydrajetting is used to place singular or dual miniholes of approximately 2-in. ID and 2 ft penetration depth to bypass the near wellbore stress field and focus the energy on generating SRV at a distance away from the disturbed near wellbore stress field (due to drilling effects). The procedure involves two steps: hydrajetting at a given depth using coiled tubing equipped with a gravity-oriented jetting tool, and then fracturing by pumping through both the annulus and the jetting tool. Large miniholes offer minimizing the energy loss created by conventional perforations, avoiding tortuous path generation, minimizing possibilities for near wellbore screen-out, and generating complex fracture networks. This paper discusses the unique mechanics of the new procedure aimed at creating large SRV in shale formations. The new technique is fairly easy to implement and the beneficial impact could be substantial. The technique and resulting benefits in fracture stimulation of shale reservoirs will be presented.
Data from Characterization of an Immunogenic Mutation in a Patient with Metastatic Triple-Negative Breast Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; The administration of autologous tumor-infiltrating lymphocytes (TILs) can mediate durable tumor regressions in patients with melanoma likely based on the recognition of immunogenic somatic mutations expressed by the cancer. There are limited data regarding the immunogenicity of mutations in breast cancer. We sought to identify immunogenic nonsynonymous mutations in a patient with triple-negative breast cancer (TNBC) to identify and isolate mutation-reactive TILs for possible use in adoptive cell transfer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; A TNBC metastasis was resected for TIL generation and whole-exome sequencing. Tandem minigenes or long 25-mer peptides encoding selected mutations were electroporated or pulsed onto autologous antigen-presenting cells, and reactivity of TIL was screened by upregulation of CD137 and IFNγ ELISPOT. The nature of the T-cell response against a unique nonsynonymous mutation was characterized.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; We identified 72 nonsynonymous mutations from the tumor of a patient with TNBC. CD4&lt;sup&gt;+&lt;/sup&gt; and HLA-DRB1*1501–restricted TILs isolated from this tumor recognized a single mutation in &lt;i&gt;RBPJ&lt;/i&gt; (recombination signal binding protein for immunoglobulin kappa J region). Analysis of 16 metastatic sites revealed that the mutation was ubiquitously present in all samples.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Breast cancers can express naturally processed and presented unique nonsynonymous mutations that are recognized by a patient's immune system. TILs recognizing these immunogenic mutations can be isolated from a patient's tumor, suggesting that adoptive cell transfer of mutation-reactive TILs could be a viable treatment option for patients with breast cancer. &lt;i&gt;Clin Cancer Res; 23(15); 4347–53. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Stable D-xylose ditriflate in divergent syntheses of dihydroxy prolines, pyrrolidines, tetrahydrofuran-2-carboxylic acids, and cyclic sugar -amino acids (2022)

Double nucleophilic displacement of a sugar D-xylose ditriflate derived from diacetone-D-glucose by amines, water and alkyl cyanoacetates gave a series of bicyclic divergent intermediates for the synthesis of a wide range of highly functionalized targets, including hydroxylated prolines, pyrrolidines, THF carboxylic acids, and cyclopentanes
Simultaneous short-path and long-path timing optimization for FPGAs (2005)

This work presents the routing cost valleys (RCV) algorithm - the first published algorithm that simultaneously optimizes all short- and long-path timing constraints in a field-programmable gate array (FPGA). RCV is comprised of a new slack allocation algorithm that produces both minimum and maximum delay budgets for each circuit connection, and a new router that strives to meet and, if possible, surpass these connection delay constraints. RCV achieves excellent results. On a set of 100 large circuits, RCV improves both long-path and short-path timing slack significantly vs. an earlier computer-aided design (CAD) system that focuses solely on long-path timing. Even with no short-path timing constraints, RCV improves the clock speed of circuits by 3.9% on average. Finally, RCV is able to meet timing on all 72 peripheral component interconnect (PCI) cores tested, while an earlier algorithm fails to achieve timing on all 72 cores.
Noninvasive Measurements of Magnetic Field Generated by Induced Current within Human Body under Exposure to Very Low Frequency Electromagnetic Fields (2005)

We have developed a measurement system for a magnetic field that is generated by the induced ionic current within the human body under exposure to very low frequency electromagnetic fields, and compared the magnetic field strength obtained with those of a magnetomyogram (MMG). The developed system consists of an exposure coil, a magnetic sensor, a lock-in detector, and data acquisition. The waveform characteristics of the magnetic field of the induced current (MFIC) of the abdomen from 1 kHz to 400 Hz are obtained. Compared with the magnetic field strength of abdominal MMG, abdominal MFIC is stronger at an exposure electromagnetic field greater than the µT order.
Driving DSA into volume manufacturing (2015)

Directed Self-Assembly (DSA) is being extensively evaluated for application in semiconductor process integration.<sup>1-7 </sup>Since 2011, the number of publications on DSA at SPIE has exploded from roughly 26 to well over 80, indicating the groundswell of interest in the technology. Driving this interest are a number of attractive aspects of DSA including the ability to form both line/space and hole patterns at dimensions below 15 nm, the ability to achieve pitch multiplication to extend optical lithography, and the relatively low cost of the processes when compared with EUV or multiple patterning options. Tokyo Electron Limited has focused its efforts in scaling many laboratory demonstrations to 300 mm wafers. Additionally, we have recognized that the use of DSA requires specific design considerations to create robust layouts. To this end, we have discussed the development of a DSA ecosystem that will make DSA a viable technology for our industry, and we have partnered with numerous companies to aid in the development of the ecosystem. This presentation will focus on our continuing role in developing the equipment required for DSA implementation specifically discussing defectivity reduction on flows for making line-space and hole patterns, etch transfer of DSA patterns into substrates of interest, and integration of DSA processes into larger patterning schemes.
Femtosecond laser pumped by high-brightness coherent polarization locked diodes (2011)

We demonstrate, for the first time to our knowledge, the use of a coherent polarization locked diode as the high-brightness pump source for a femtosecond laser. Four diode emitters are coherently locked to produce more than 5 W linearly polarized, narrow linewidth, and single-lobed pump beam. This gives >10× brightness improvement over the conventional diode array. The diode beam is then used to pump a Yb:KYW laser to obtain 2 W output with 57% slope efficiency in cw laser operation. By using a saturable absorber mirror, we achieved cw mode-locking operation with a 177 fs pulse width at an average power of 0.55 W.
Effect of Porogen Residue on Chemical, Optical, and Mechanical Properties of CVD SiCOH Low-k Materials (2009)

The effect of He/H-2 downstream plasma on chemical vapor deposition (CVD) low-k films with different porosities was studied. The results show that this plasma does not reduce the concentration of Si-CH3 bonds in the low-k matrix and that the films remain hydrophobic. However, mass loss and reduction in bulk C concentration were observed. The latter phenomena are related to the removal of porogen residue formed during the UV curing of the low-k films. It is demonstrated that the porogen residue removal changes the films' porosity and mechanical properties. The depth of the modification is limited by the penetration of H radicals into the porous low-k films.
El renacer de un mercado. (2002)

Estos intermediarios financieros comenzaron a presentar negocio a los bancos, lo que finalmente ha hecho que estos no tengan que desarrollar una gran presencia en el mercado.
The Satellite‐Shaped Co‐15 Polyoxotungstate, [Co6(H2O)30{Co9Cl2 (OH)3(H2O)9 (β‐SiW8O31)3}]5‐. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Relative efficiency of incorporation of newly synthesized elastin and collagen into aorta, pulmonary artery and pulmonary vein of growing pigs (1993)

It is generally accepted that, once laid down in the extracellular matrix, elastin turns over only very slowly if at all. However, much of the evidence for minimal turnover of elastin comes from aortic tissue. In this study we have compared the relative synthesis rates of elastin and collagen with their relative accumulation rates in segments of aorta (AO), pulmonary artery (PA), and pulmonary vein (PV) of young, growing pigs. While rates of elastin synthesis are comparable in the AO and PA, the PA accumulates only 33% of the elastin deposited in the AO. Similarly, while the rate of elastin synthesis in the PV is 60% of that in the AO, accumulation of elastin is only 20% of that in the AO. Similar discrepancies between collagen synthesis and accumulation were seen among these three vessels. These data suggest that, at least in growing animals, the efficiency of permanent incorporation of elastin and collagen into the extracellular matrix may be an important factor in determining the final contents of these connective tissue proteins in vascular tissues.
Experimental verification of substrate-induced bianisotropy in optical metamaterials (2013)

This paper reports on substrate-induced bianisotropy in an impedance-matched near-zero-index metallodielectric fishnet nanostructure with vertical sidewalls and a supporting substrate. The effect of bianisotropy on the metamaterial optical properties is confirmed through spectral holography measurements and full-wave electromagnetic simulations, showing asymmetric reflection coefficients from opposite sides of the structure at normal incidence. The non-zero magnetoelectric coupling parameter causes a 0.03 μm shift in the near-infrared zero-index band centered at 1.5 μm and a 38% reduction in transmitted power. The substrate-induced bianisotropy is due to the excitation of an anti-symmetric plasmonic resonance mode identified by comparing simulations of the current distributions on free-standing and substrate-mounted fishnet structures. This experimental demonstration of substrate-induced bianisotropy verifies the previously proposed theory and provides valuable guidance for future plasmonic and metamaterial nanostructures that include substrates.
mRNA Engineering for the Efficient Chaperone-Mediated Co-Translational Folding of Recombinant Proteins in Escherichia coli (2019)

The production of soluble, functional recombinant proteins by engineered bacterial hosts is challenging. Natural molecular chaperone systems have been used to solubilize various recombinant proteins with limited success. Here, we attempted to facilitate chaperone-mediated folding by directing the molecular chaperones to their protein substrates before the co-translational folding process completed. To achieve this, we either anchored the bacterial chaperone DnaJ to the 3' untranslated region of a target mRNA by fusing with an RNA-binding domain in the chaperone-recruiting mRNA scaffold (CRAS) system, or coupled the expression of DnaJ and a target recombinant protein using the overlapping stop-start codons 5'-TAATG-3' between the two genes in a chaperone-substrate co-localized expression (CLEX) system. By engineering the untranslated and intergenic sequences of the mRNA transcript, bacterial molecular chaperones are spatially constrained to the location of protein translation, expressing selected aggregation-prone proteins in their functionally active, soluble form. Our mRNA engineering methods surpassed the in-vivo solubilization efficiency of the simple DnaJ chaperone co-overexpression method, thus providing more effective tools for producing soluble therapeutic proteins and enzymes.
New tools for visualization and analysis of morphogenesis in spherical embryos (2006)

Abstract Texture rendering of three‐dimensional Surface Imaging Microscopy (SIM) date acquired in a fixed late gastrula stage Xenopus laevis embryo. The rendering at center has been section to show the internal surfaces of the blastocoel and archenteron. The surrounding images show central coronal, sagittal, and equitorial sections through the same date. The original SIM spatial resolution was approximately 1.7 microns in each dimension. See Tyszka et al., Developmental Dynamics 234:974–983. © 2006 Wiley‐Liss, Inc.
Incidence and risk factors of hardware-related complications after proximal femoral osteotomy in children and adolescents (2017)

Therapeutic Level III.
Neutrally colourless, transparent and thermally stable polynorbornenes via ring-opening metathesis polymerisation for near-infrared electroactive applications (2011)

Two novel near-infrared (NIR) electrochromic polynorbornenes, poly(NBDTPA) and poly(HNBDTPA), containing electroactive chromophores, were prepared via ring-opening metathesis polymerisation from a new norbornene derivative (NBDTPA) using Grubbs' catalysts followed by hydrogen reduction. The glass transition temperatures (Tg) of poly(NBDTPA) and hydrogenated poly(HNBDTPA) were 141 °C and 91 °C, respectively. The 10% weight-loss temperatures of hydrogenated poly(HNBDTPA) and poly(NBDTPA) were up to 440 °C and 397 °C, respectively. Hydrogenated poly(HNBDTPA) film showed excellent transparency (up to 91%). Poly(NBDTPA) showed a cyclic voltammogram and electrochromic behaviour that was similar to poly(HNBDTPA). The cyclic voltammogram of a poly(HNBDTPA) film cast onto an indium-tin oxide (ITO)-coated glass substrate exhibited three reversible oxidation redox couples at 0.63, 0.82 and 1.23 V vs. Ag/Ag+ in acetonitrile solution. The electrochromic characteristics of poly(HNBDTPA) showed excellent stability and reversibility, with multi-stage colour changes from its colourless neutral form to green, light-blue and dark-blue with applied potentials of 0 to 1.75 V. The colour switching time and bleaching time of the poly(HNBDTPA) were 7.1 s and 4.2 s in the near-infrared region (1230 nm), and 7.4 s and 4.5 s in the UV-vis region (420 nm), respectively.