gebhart/patrepeval huggingface dataset:
Renal ischemia induces tropomyosin dissociation-destabilizing microvilli microfilaments (2004)

Ischemic-induced cell injury results in rapid duration-dependent actin-depolymerizing factor (ADF)/cofilin-mediated disruption of the apical microvilli microfilament cores. Because intestinal microvillar microfilaments are bound and stabilized in the terminal web by the actin-binding protein tropomyosin, we questioned whether a protective effect of tropomyosin localization to the terminal web of the proximal tubule microfilament cores is disrupted during ischemic injury. With tropomyosin-specific antibodies, we examined rat cortical sections under physiological conditions and following ischemic injury by confocal microscopy. In addition, Western blot analysis of cortical extracts and urine was undertaken. Our studies demonstrated the presence of tropomyosin isoforms in the proximal tubule microvillar terminal web under physiological conditions and their dissociation in response to 25 min of ischemic injury. This correlated with the excretion of tropomyosin-containing plasma membrane vesicles in urine from ischemic rats. In addition, we noted increased tropomyosin Triton X-100 solubility following ischemia in cortical extracts. These studies suggest tropomyosin binds to and stabilizes the microvillar microfilament core in the terminal web under physiological conditions. With the onset of ischemic injury, we propose that tropomyosin dissociates from the microfilament core providing access to microfilaments in the terminal web for F-actin binding, severing and depolymerizing actions of ADF/cofilin proteins.
Letter to the Editor: Authentic Digital Objects (2009)

Long-term preservation of digital objects requires curators to be able to guarantee the archival authenticity of the objects in a digital repository. In IJDC 4(1), Ronald Jantz suggested that a digital certificate is sufficient to ensure authenticity. The letter writer takes issue with this view and points out some of the archival misinterpretations in the Jantz article. He maintains that the archival literature is a rich source for discussions of authenticity that has been ignored to the detriment of Jantz’s arguments.
Electronic Confinement of Molecules in Microscopic Pores. A New Concept Which Contributes to the Explanation of the Catalytic Activity of Zeolites (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic Confinement of Molecules in Microscopic Pores. A New Concept Which Contributes to the Explanation of the Catalytic Activity of ZeolitesC. M. Zicovich-Wilson, A. Corma, and P. ViruelaCite this: J. Phys. Chem. 1994, 98, 42, 10863–10870Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/j100093a030https://doi.org/10.1021/j100093a030research-articleACS PublicationsRequest reuse permissionsArticle Views602Altmetric-Citations125LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Detection of Colistin Resistance in Salmonella enterica Using MALDIxin Test on the Routine MALDI Biotyper Sirius Mass Spectrometer (2020)

Resistance to polymyxins in most Gram-negative bacteria arises from chemical modifications to the lipid A portion of their lipopolysaccharide (LPS) mediated by chromosomally encoded mutations or the recently discovered plasmid-encoded <i>mcr</i> genes that have further complicated the landscape of colistin resistance. Currently, minimal inhibitory concentration (MIC) determination by broth microdilution, the gold standard for the detection of polymyxin resistance, is time consuming (24 h) and challenging to perform in clinical and veterinary laboratories. Here we present the use of the MALDIxin to detect colistin resistant <i>Salmonella enterica</i> using the MALDxin test on the routine matrix-assisted laser desorption ionization (MALDI) Biotyper Sirius system.
An Android-based application for digital gait performance analysis and rehabilitation (2015)

This paper presents an Android application supporting digital analysis of human gait patterns in a far more flexible way. The application uses the Bluetooth connection and a Shimmer 2R sensor to receive the raw accelerometer signals from typical and atypical gait, followed by a real-time data processing and monitoring to assess the gait quality. On the whole, 7 features per acceleration direction are made available for users. The range of features can be easily redefined and adjusted for the application in diverse type of gait/limb impairments. The user can choose a variety of features, allowing to determine gait abnormalities, quantify gait and walking performance and display them on the screen. The outcomes can be saved on the device or transmitted to treating physicians for a later control of the subject's improvements and the efficiency of physiotherapy treatments in motor rehabilitation. The proposed software solution bears a great potential to be commercialized and deployed to support digital healthcare and therapy.
Metadata for the Long Term: The Universality of Language vs. Fixed Processes (2001)

Effective digital media management relies heavily on the use of descriptive information, or “metadata,” that envelops rich media files like video clips, audio files, high resolution photographs, and CAD/3D files. Good metadata permit quick search, extensive reuse, and consequently cost savings. If the metadata are inadequate, the file languishes unused and unusable. We propose a standard for metadata that does away with the trouble and expense (and inherent frustrations) of mandating terminology and thesaurus standards.
Efficient solution-processed small-molecule solar cells with titanium suboxide as an electric adhesive layer (2014)

We demonstrate efficient and air-stable small-molecule bulk heterojunction (SM BHJ) solar cells by introducing titanium suboxide (TiOx) between the active layer and the cathode as an electric adhesive layer. The SM BHJ solar cell with the TiOx interlayer exhibits improved power conversion efficiency of 6.4% as well as greatly enhanced device lifetime. Analysis of the dark diode characteristics and comparison of the current density-voltage characteristics upon heat annealing indicate that the TiOx interlayer improves the electrical contact between the active layer and the cathode, thereby resulting in efficient sweep-out of photogenerated charge carriers.
Dynamic platform for moving organ imaging (2006)

A multimodality platform (CT, PET, Radiotherapy) has been developed in order to move phantoms (maximum weight: 70kg). This allows the study of the influence of motion on image quality. The translation system (160 mm in the z axis, maximal speed of 50 mm × s<sup>-1</sup>) was controlled by a computer via a NI Motion Controller PCI 7344 (National Instrument, TX, USA). As an initial experiment, an anthropomorphic cardiac CT phantom (QRM, Moehrendorf, Germany) was moved linearly with speeds of 5, 10 and 20 mm × s<sup>-1</sup>. Acquisitions were done on a Siemens Somatom Volume Zoom CT Scanner. To compare dynamic and static images, mutual information, correlation coefficient, standard deviation, volume computation and radiologist scoring were conducted. The mean position error of the platform was 0.1mm ± 0.04. Automatic evaluation of the image quality and/or the blurring is not easy. As predicted, we found an increase in artifacts with the speed of the phantom. The platform allows us to simulate physiological motions (respiratory and cardiac) in order to study their real influence on image quality and to correct them. We can already produce z axis physiological motion with the platform. More degrees of freedom (y and z rotations, x and y translations) will be added to improve the simulation of physiological motions.
Outpatient Transurethral Resection of the Prostate at a Urological Ambulatory Surgery Center (1994)

Transurethral resection of the prostate has been the standard treatment for patients with benign prostatic hyperplasia, and it has traditionally required 2 to 7 days of hospitalization. Since 1991 we performed outpatient transurethral resection of the prostate at a urological ambulatory surgery center on 125 select patients. Standard resection techniques were used with particular attention to hemostasis, since bladder irrigation was stopped before patients were discharged home. Transfer to a hospital was required for 3 patients because of hematuria, 1 for fever and suspected bacteremia, and 1 for cardiac dysrhythmia. No patient required hospitalization after he was discharged from the ambulatory surgery center. Outpatient transurethral resection of the prostate can be performed safely with excellent patient satisfaction and cost-effectiveness. Alternative treatment modalities for benign prostatic hyperplasia should be evaluated against outpatient transurethral resection of the prostate before they are broadly embraced.
Data-retention time prediction of long-term archive SSD with flexible-nLC NAND flash (2016)

This paper proposes a new method to predict the data-retention time of long-term archive SSD with flexible-nLC NAND flash. This paper first reports that the conventional prediction overestimates the data lifetime based on the long-term data retention measurement. Then, a more precise prediction is proposed. By using this proposal, the most reliable and lowest cost memory architecture is determined. As a result, over 100-year data-retention is achieved, which is 25-times longer than the conventional TLC NAND flash memory.
Application of novel cumulative phasor sum measurement for earth-fault protection in compensated MV-networks (2013)

This paper describes a novel algorithm for feeder earthfault protection in compensated MV-networks. The algorithm combines optimal transient and steady-state performance into one function. The operation of the algorithm is based on multi-frequency neutral admittance measurement using the cumulative phasor summing technique. The main advantage of the proposed concept is that it provides valid measurement results regardless of the fault resistance value and the fault type, whether the fault has permanent, transient or an intermittent character. It also simplifies the applied protection scheme as coordination between separate protection functions dedicated to different fault types is no longer needed. First the paper introduces the theory of multi-frequency neutral admittance measurement. Secondly, the cumulative phasor summing technique is applied in this protection principle. Finally, the performance of the suggested protection algorithm is evaluated and compared with traditional earth-fault protection functions using data from simulations and comprehensive field tests conducted in a large 10 kV cable network with central and distributed compensation. The results show that the overall security and dependability of the protection can be significantly improved compared with the traditional earth-fault protection functions.
Production of micronic particles of biocompatible polymer using supercritical carbon dioxide (1997)

Three micronization techniques, based on the use of supercritical carbon dioxide, were investigated to produce microspheres of a natural biocompatible polysaccharide. Particles smaller than 20 mum were obtained by means of the rapid expansion of a supercritical solution method (RESS), both with and without cosolvents. The mean diameter of the particles was reduced to about 0.5 mum when a solution of the polymer in an organic solvent was expanded by using carbon dioxide as a supercritical antisolvent (SAS). The SAS process was operated both in a continuous and in a batch mode. The former leads to aggregated structures and fibers, and the latter to the formation of micronic spherical particles. It was found that the experimental temperature did not substantially affect the shape and dimension of the particles. A stronger dependence is shown with respect to the solute concentration in the starting solution. The proposed method is attractive as the basis of a new process for the preparation of drug delivery systems. (c) 1997 John Wiley & Sons, Inc.
In vitro interaction between components of the inner membrane complex of the maltose ABC transporter of Escherichia coli : modulation by ATP (1998)

Interactions between domains of ATP-binding cassette (ABC) transporters are of great functional importance and yet are poorly understood. To gain further knowledge of these protein-protein interactions, we studied the inner membrane complex of the maltose transporter of Escherichia coli. We focused on interactions between the nucleotide-binding protein, MalK, and the transmembrane proteins, MalF and MalG. We incubated purified MalK with inverted membrane vesicles containing MalF and MalG. MalK bound specifically to MalF and MalG and reconstituted a functional complex. We used this approach and limited proteolysis with trypsin to show that binding and hydrolysis of ATP, inducing conformational changes in MalK, modulate its interaction with MalF and MalG. MalK in the reconstituted complex was less sensitive to protease added from the cytoplasmic side of the membrane, and one proteolytic cleavage site located in the middle of a putative helical domain of MalK was protected. These results suggest that the putative helical domain of the nucleotide-binding domains is involved, through its conformational changes, in the coupling between the transmembrane domains and ATP binding/hydrolysis at the nucleotide-binding domains.
Detection of faulty high speed wind turbine bearing using signal intensity estimator technique (2017)

Abstract Bearings are typically used in wind turbines to support shafts and gears that increase rotational speed from a low speed rotor to a higher speed electrical generator. For various bearing applications, condition monitoring using vibration measurements has remained a subject of intense study to the present day since several decades. Various signal processing techniques are used to analyse vibration signals and extract features related to defects. Statistical indicators such as Crest Factor (CF) and Kurtosis (KU) were reported as very sensitive indicators when the presence of the defects is pronounced, whilst their values may come down to the level of undamaged components when the damage is well advanced. Further, these indicators were applied to an acquired data from proposed diagnostic models, test rigs, and instrumentations that were specifically used for particular research tests, and thus, it is essential to undertake further investigations and analysis to assess the influence of other factors such as the structural noise and other operating conditions on the real‐world applications. With this in mind, the present work proposes Signal Intensity Estimator (SIE) as a new technique to discriminate individual types of early natural damage in real‐world wind turbine bearings. Comparative results between SIE and conventional indicators such as KU and CF are also presented. It was concluded that SIE has an advantage over the other fault indicators if sufficient data are provided.
Field‐Switchable Broadband Polarizer Based on Reconfigurable Nanowire Assemblies (2016)

Reconfigurability is one of the most critical properties of nanophotonic systems and, consequently, methods for enabling a significant degree of functionality are highly sought after. However, dynamically responsive control in top‐down fabricated photonic structures often requires extreme conditions and yields moderate modulation capability. In sharp contrast to top‐down methods, directed self‐assembly of micro‐ and nanoparticles offers a distinct avenue for reconfigurable photonics. In the present work, gold nanowire lattices are formed via electric field directed assembly in order to take advantage of their collective optical properties. The lattices are reconfigured on‐demand between two different functional states, in the form of broadband polarizers. By selectively switching the electric field between two orthogonal electrode pairs, a maximum transmission contrast of ≈50% is observed in the near‐infrared regime. Moreover, the reconfigurable transmission spectra, which are highly dependent on the nanowire size and electric field conditions, are reversible. The demonstrated proof‐of‐concept nanowire lattice polarizer provides potential for electrically reconfigurable photonic devices such as ultra‐compact polarization components, electro‐optic switches, and on‐chip modulators.
Fiber Optic Fabry-Perot Sensors Embedded in Metal and in a Composite (2005)

In recent years a strong interest has developed in embedded fiber optic sensors for the monitoring of strain, temperature, and other parameters in structural materials [1]. The fiber Fabry-Perot interferometer (FFPI) using internal mirrors [2-4] is a strong candidate for this application because it provides localized (point) sensing capability and high sensitivity, and is amenable to time-division multiplexing. Here, new results on the embedding of FFPIs in metals and composites are reported.
Genetic inactivation of pro-glycolytic enzyme PFKFB3 in astrocytes as a tool to investigate neuronal function (2019)

Resumen del trabajo presentado al Spanish Society of Biochemistry and Molecular Biology (SEBBM), celebrado en Madrid del 16 al 19 de julio de 2019.
Predicting the stability of cyclic disulfides by molecular modeling: effective concentrations in thiol-disulfide interchange and the design of strongly reducing dithiols (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPredicting the stability of cyclic disulfides by molecular modeling: effective concentrations in thiol-disulfide interchange and the design of strongly reducing dithiolsJohn A. Burns and George M. WhitesidesCite this: J. Am. Chem. Soc. 1990, 112, 17, 6296–6303Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August 1990https://pubs.acs.org/doi/10.1021/ja00173a017https://doi.org/10.1021/ja00173a017research-articleACS PublicationsRequest reuse permissionsArticle Views1195Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High‐Temperature Stability of Lanthanum Orthophosphate (Monazite) on Silicon Carbide at Low Oxygen Partial Pressures (2008)

The stability of lanthanum orthophosphate (LaPO 4 ) on SiC was investigated using a LaPO 4 ‐coated SiC fiber at 1200°–1400°C at low oxygen partial pressures. A critical oxygen partial pressure exists below which LaPO 4 is reduced in the presence of SiC and reacts to form La 2 O 3 or La 2 Si 2 O 7 and SiO 2 as the solid reaction products. The critical oxygen partial pressure increases from ∼0.5 Pa at 1200°C to ∼50 Pa at 1400°C. Above the critical oxygen partial pressure, a thin SiO 2 film, which acts as a reaction barrier, exists between the SiC fiber and the LaPO 4 coating. Continuous LaPO 4 coatings and high strengths were obtained for coated fibers that were heated at or below 1300°C and just above the critical oxygen partial pressure for each temperature. At temperatures above 1300°C, the thin LaPO 4 coating becomes morphologically unstable due to free‐energy minimization as the grain size reaches the coating thickness, which allows the SiO 2 oxidation product to penetrate the coating.
A Two-Dimensional Feature Space-Based Approach for Human Locomotion Recognition (2019)

The current state-of-the-art methods utilize multiple sensors and derive numerous features to perform human locomotion recognition. The use of multiple sensors causes discomfort to the users. Also, the derivation of numerous features for multiple sensors poses real-time processing issues. This paper presents a real-time human locomotion recognition system using a single inertial measurement unit placed on the human thigh to capture thigh angular data. Two features, amplitude (A) and omega (ω), are derived from the adaptive time window of thigh angular data. An adaptive time window is built using two consecutive peaks in the thigh angle signal. The machine learning algorithms, such as linear support vector machine and k-nearest neighbors, are employed on the A-ω feature space to perform the classification. A total number of six periodic activities are considered in this paper that includes level walking, stair ascent, stair descent, uphill, downhill, jogging, and running. The experiments are performed on six healthy subjects in controlled (motion capture laboratory) and uncontrolled (outdoor) environmental conditions to evaluate the efficacy of the algorithm. The A-ω feature-based method achieved a significant classification accuracy of 98.1% and 93.3% for controlled and uncontrolled experiments, respectively. Also, it reported a fast mean activity recognition time of 80 ms.
Treatment of mycosis fungoides lymphoma: effectiveness of infusions of methotrexate followed by oral citrovorum factor. (1978)

Eleven patients with stage II or III mycosis fungoides lymphoma were treated with a regimen consisting of iv infusions of methotrexate (MTX) (60-240 mg/m2) administered sequentially and oral citrovorum factor. All 11 patients experienced a good to excellent response. Complete remissions were induced in seven of the 11 patients. In most cases remissions were sustained with weekly administration of low-dose (25--50 mg) MTX. Adverse drug reactions, such as leukopenia, anemia, and mucositis, were minimal in degree. Some unique adverse reactions included skin ulcerations (three patients), a leukocytoclastic angiitis (one patient), and painful hands and feet during MTX infusions (two patients). Our experience with this regimen has led us to conclude that it is safe and very effective in the treatment of stages II and III of mycosis fungoides.