gebhart/patrepeval huggingface dataset:
Correction to “ ‘Quick-Silver’ from a Systematic Study of Highly Luminescent, Two-Coordinate, d10 Coinage Metal Complexes (2022)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to " 'Quick-Silver' from a Systematic Study of Highly Luminescent, Two-Coordinate, d10 Coinage Metal ComplexesJonas SchaabJonas SchaabMore by Jonas Schaab, Rasha HamzeRasha HamzeMore by Rasha Hamze, Shuyang ShiShuyang ShiMore by Shuyang Shi, Savannah C. KapperSavannah C. KapperMore by Savannah C. Kapperhttps://orcid.org/0000-0001-8222-8495, Daniel Sylvinson Muthiah RavinsonDaniel Sylvinson Muthiah RavinsonMore by Daniel Sylvinson Muthiah Ravinsonhttps://orcid.org/0000-0002-3336-1983, Laura EstergreenLaura EstergreenMore by Laura Estergreenhttps://orcid.org/0000-0003-2534-534X, Moon-Chul JungMoon-Chul JungMore by Moon-Chul Junghttps://orcid.org/0000-0001-7571-3767, Abegail C. TadleAbegail C. TadleMore by Abegail C. Tadlehttps://orcid.org/0000-0002-3802-6818, Ralf HaigesRalf HaigesMore by Ralf Haigeshttps://orcid.org/0000-0003-4151-3593, Peter I. DjurovichPeter I. DjurovichMore by Peter I. Djurovichhttps://orcid.org/0000-0001-6716-389X, Jesse L. PeltierJesse L. PeltierMore by Jesse L. Peltier, Rodolphe JazzarRodolphe JazzarMore by Rodolphe Jazzarhttps://orcid.org/0000-0002-4156-7826, Guy BertrandGuy BertrandMore by Guy Bertrand, Stephen E. BradforthStephen E. BradforthMore by Stephen E. Bradforthhttps://orcid.org/0000-0002-6164-3347, and Mark E. Thompson*Mark E. ThompsonMore by Mark E. Thompsonhttps://orcid.org/0000-0002-7764-4096Cite this: J. Am. Chem. Soc. 2023, 145, 2, 1470–1471Publication Date (Web):December 28, 2022Publication History Received29 November 2022Published online28 December 2022Published inissue 18 January 2023https://pubs.acs.org/doi/10.1021/jacs.2c12680https://doi.org/10.1021/jacs.2c12680correctionACS PublicationsCopyright © 2022 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1238Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (993 KB) Get e-Alertsclose Get e-Alerts
A Differentiable Perceptual Audio Metric Learned from Just Noticeable Differences (2020)

Many audio processing tasks require perceptual assessment. The ``gold standard`` of obtaining human judgments is time-consuming, expensive, and cannot be used as an optimization criterion. On the other hand, automated metrics are efficient to compute but often correlate poorly with human judgment, particularly for audio differences at the threshold of human detection. In this work, we construct a metric by fitting a deep neural network to a new large dataset of crowdsourced human judgments. Subjects are prompted to answer a straightforward, objective question: are two recordings identical or not? These pairs are algorithmically generated under a variety of perturbations, including noise, reverb, and compression artifacts; the perturbation space is probed with the goal of efficiently identifying the just-noticeable difference (JND) level of the subject. We show that the resulting learned metric is well-calibrated with human judgments, outperforming baseline methods. Since it is a deep network, the metric is differentiable, making it suitable as a loss function for other tasks. Thus, simply replacing an existing loss (e.g., deep feature loss) with our metric yields significant improvement in a denoising network, as measured by subjective pairwise comparison.
Host responses to the human microbiome (2012)

The human gut is home to vast numbers of bacteria (gut microbiota), which outnumber the cells in the human body by an order of magnitude. The gut microbiota has coevolved with humans and can be considered an organ of similar size as the liver, containing more than 1,000 cell types (bacterial species) and encoding 150-fold more genes than are present in the human genome. Accordingly, the gut microbiota may have profound effects on various host responses, either directly or indirectly, by modifying food components or endogenously produced molecules into signaling molecules. Recent findings suggest that an altered gut microbial composition is associated with inflammatory bowel disease and obesity, indicating that the gut microbiota should be considered a contributing factor in several common diseases.
Thermoregulatory uncoupling in heart muscle mitochondria: involvement of the ATP/ADP antiporter and uncoupling protein (1998)

Possible involvement of the ATP/ADP antiporter and uncoupling protein (UCP) in thermoregulatory uncoupling of oxidative phosphorylation in heart muscle has been studied. To this end, effects of carboxyatractylate (cAtr) and GDP, specific inhibitors of the antiporter and UCP, on the membrane potential of the oligomycin-treated mitochondria from cold-exposed (6 degrees C, 48 h) and control rats have been measured. It is found that cAtr increases the membrane potential level in both cold-exposed and non-exposed groups, the effect being strongly enhanced by cooling. As for GDP, it is effective only in mitochondria from the cold-exposed rats. In these mitochondria, the coupling effect of GDP is smaller than that of cAtr. CDP, which does not interact with UCP, is without any influence on membrane potential. The cold exposure is found to increase the uncoupling efficiency of added natural (palmitate) or artificial (SF6847) uncouplers, the increase being cAtr- and GDP-sensitive in the case of palmitate. The fatty acid-free bovine serum albumin enhances delta psi in both cold-exposed and control groups, the effect being much larger in the former case. It is concluded that in heart muscle mitochondria the ATP/ADP antiporter is responsible for the 'mild uncoupling' under normal conditions and for major portion of the thermoregulatory uncoupling in the cold whereas the rest of thermoregulatory uncoupling is served by UCP (presumably by UCP2 since the UCP2 mRNA level is shown to strongly increase in rat heart muscle under the cold exposure conditions used).
Isap -- Towards Side-Channel Secure Authenticated Encryption (2017)

Side-channel attacks and in particular differential power analysis (DPA) attacks pose a serious threat to cryptographic implementations. One approach to counteract such attacks are cryptographic schemes based on fresh re-keying. In settings of pre-shared secret keys, such schemes render DPA attacks infeasible by deriving session keys and by ensuring that the attacker cannot collect side-channel leakage on the session key during cryptographic operations with different inputs. While these schemes can be applied to secure standard communication settings, current re-keying approaches are unable to provide protection in settings where the same input needs to be processed multiple times. In this work, we therefore adapt the re-keying approach and present a symmetric authenticated encryption scheme that is secure against DPA attacks and that does not have such a usage restriction. This means that our scheme fully complies with the requirements given in the CAESAR call and hence, can be used like other noncebased authenticated encryption schemes without loss of side-channel protection. Its resistance against side-channel analysis is highly relevant for several applications in practice, like bulk storage settings in general and the protection of FPGA bitfiles and firmware images in particular.
An intact ING1-p53 pathway can potentiate the cytotoxic effects of taxol (2005)

Commentary to: The Tumor Suppressor p33ING1b Enhances Taxol-Induced Apoptosis by p53-Dependent Pathway in Human Osteosarcoma U2OS Cells Jin-Jun Zhu, Fo-Bao Li, Jun-Min Zhou, Zong-Chao Liu, Xiao-Feng Zhu, Wei-Ming Liao
Application of nanoengineering to research and development and production of high strength steel sheets (2013)

The design concepts and properties of three unique high strength steel sheets developed utilising nanoengineering are reviewed. The first steel is developed by optimising the distribution of nanoprecipitates and exhibits low yielding ratio in spite of being strengthened by grain refinement and precipitation hardening. The second is the ferrite single phase tensile strength 780 MPa grade advanced high strength steel sheet utilising the thermally stable nanosized precipitates, which possesses significantly well balanced elongation and stretch flangeability. These two were already commercialised. The last is the ultrahigh strength steel, of which the formability is enhanced by optimising the combination of hard phases. The steel consists of bainite, retained austenite and tempered martensite and exhibits 35 of elongation with 1470 MPa of tensile strength. Although further optimisation of the composition and the processing are needed to produce and commercialise the steel, the results indicate that the approach has the potential to improve formability dramatically.
Training for Digital Forensics and Incident Response (2023)

The work of an digital forensics expert is far more extensive and varied today than it was just a few years ago. Especially after hacking attacks on organizations, experts in DFIR (Digital Forensics and Incident Response) come into play. In this paper, we present a learning platform that enables people to learn DFIR from scratch. To achieve this goal, the content of the learning platform was defined, evaluated and prepared with the help of experts from industry and government. For this purpose, expert interviews were conducted, which were subsequently evaluated. The results of these interviews were incorporated into initial scenarios that were implemented in individual modules on the learning platform Ilias, with a distinction being made between the basics and the main DFIR part. In the basic part, an introduction to IT forensics is offered, which is supplemented by further technical modules. This includes training in the use of the Linux operating system, which is frequently used in digital forensics, as well as the acquisition and analysis of RAM iand hard disk images. In the main part, the focus is to apply the learnings from the basic sections and to enhance them with incident related knowledge for DFIR projects, in which digital forensics experts gather and analyse evidence on various systems of the attacked organizations by searching and gathering so-called IoCs (Indicators of Compromise) from log files and other sources. Once the analysis part is complete, and all evidence has been collected, cleanup, recovery and restart of systems may take place, which is handled in the last section of the main training module.
Charakterystyki ekologiczne silników spalinowych w stanach przypadkowych (2016)

Praca dotyczy metody oceny emisji zanieczyszczeń i zużycia paliwa dla&#13;\nsilników spalinowych o różnych zastosowaniach, pracujących w stanach&#13;\nprzypadkowych. Stany przypadkowe pracy silnika, to takie, które nie są&#13;\nzdeterminowane schematem narzucanych warunków pracy, a w&#13;\nszczególności nie są ograniczane do stanów statycznych. Proponowana&#13;\nmetoda jest uniwersalna w stosunku do silników spalinowych o&#13;\nzastosowaniach zarówno samochodowych, jak i innych. Wyznaczane dzięki&#13;\nniej charakterystyki mogą być wykorzystane do bilansowania emisji&#13;\nzanieczyszczeń i zużycia paliwa dla silników spalinowych o różnych&#13;\nzastosowaniach.
Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus (2017)

The thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor that is essential for thymus organogenesis; however, the direct target for Foxn1 to actuate thymic T-cell production is unknown. Here we show that a Foxn1-binding cis-regulatory element promotes the transcription of β5t, which has an essential role in cortical thymic epithelial cells to induce positive selection of functionally competent CD8<sup>+</sup> T cells. A point mutation in this genome element results in a defect in β5t expression and CD8<sup>+</sup> T-cell production in mice. The results reveal a Foxn1-β5t transcriptional axis that governs CD8<sup>+</sup> T-cell production in the thymus.
Data layout management for energy-saving key-value storage using a write off-loading technique (2012)

The objective of our research has been to achieve energy-saving key-value store system. We introduce architecture of our distributed key value store and control framework for energy saving. To reduce power consumption, the control framework should reduce the time required before node power-down. Since this time depends heavily on the amount of data migration, we employ an approach which reduce that amount. We describe and evaluate three control strategies that can be executed on this control framework, each consisting of a data allocation algorithm and data control layout algorithm for use when nodes are to be powered down. With a prototype system developed for evaluation purposes, the time required before node power down is reduced by use of our proposed data allocation algorithm, by means of its taking into account the possible presence of Write off-loading nodes.
Optical systems for laser thermal printing (2004)

This paper is an overview of the optical designs used in array-type multispot laser thermal printers. A variety of unique systems have been developed for high-power high-throughput printing applications where laser light is generally transformed into a linear arrangement of modulated beams focused onto light-sensitive media. The typical light source is a monolithic laser diode array that emits a series of anamorphic partially coherent infrared beams. An optical system, comprising anamorphic, micro-optics, and designed according to principles from classical imaging optics, illumination optics, and Gaussian beam optics, is needed to conduct the light to the media. Special optical components, including rod lenses, laser smile correctors, or spatial light modulator arrays may be employed. Because the printing applications are highly sensitive to repetitive artifacts, the designs typically provide light source redundancy and light homogenization. The interaction of the incident light with the thermal media can also affect the design. These various optical design issues, and a number of design solutions, are the subjects of this review paper.
Combinations of Griffithsin with Other Carbohydrate-Binding Agents Demonstrate Superior Activity Against HIV Type 1, HIV Type 2, and Selected Carbohydrate-Binding Agent-Resistant HIV Type 1 Strains (2012)

Carbohydrate-binding agents (CBAs) are potential HIV microbicidal agents with a high genetic barrier to resistance. We wanted to evaluate whether two mannose-specific CBAs, recognizing multiple and often distinct glycan structures on the HIV envelope gp120, can interact synergistically against HIV-1, HIV-2, and HIV-1 strains that were selected for resistance against particular CBAs [i.e., 2G12 mAb and microvirin (MVN)]. Paired CBA/CBA combinations mainly showed synergistic activity against both wild-type HIV-1 and HIV-2 but also 2G12 mAb- and MVN-resistant HIV-1 strains as based on the median effect principle with combination indices (CIs) ranging between 0.29 and 0.97. Upon combination, an increase in antiviral potency of griffithsin (GRFT) up to ∼12-fold (against HIV-1), ∼8-fold (against HIV-2), and ∼6-fold (against CBA-resistant HIV-1) was observed. In contrast, HHA/GNA combinations showed additive activity against wild-type HIV-1 and HIV-2 strains, but remarkable synergy with HHA and GNA was observed against 2G12 mAb- and MVN-resistant HIV-1 strains (CI, 0.64 and 0.49, respectively). Overall, combinations of GRFT and other CBAs showed synergistic activity against HIV-1, HIV-2, and even against certain CBA-resistant HIV-1 strains. The CBAs tested appear to have distinct binding patterns on the gp120 envelope and therefore do not necessarily compete with each other's glycan binding sites on gp120. As a result, there might be no steric hindrance between two different CBAs in their competition for glycan binding (except for the HHA/GNA combination). These data are encouraging for the use of paired CBA combinations in topical microbicide applications (e.g., creams, gels, or intravaginal rings) to prevent HIV transmission.
Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips (2018)

Scalable Fabrication Of Stretchable Dual Channel Microfluidic Organ Chips - Video. JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our scientific video articles. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research, scientific journals, and education. Millions of scientists, educators and students at thousands of universities, colleges, hospitals and biopharmaceutical companies worldwide use JoVE for their research, teaching and learning.
Polymethyl methacrylate: Optical properties from 191 to 1688 nm (0.735–6.491 eV) by spectroscopic ellipsometry (2020)

Poly(methyl methacrylate) (PMMA), known commercially by the trade name Plexiglas®, is an important polymer with numerous applications. This acrylic-based glass is often used as an alternative to conventional glass. Herein, the authors derive the optical functions of PMMA from reflection spectroscopic ellipsometry (SE) and transmission ultraviolet-visible intensity data. These functions were obtained from a 3 mm thick commercial sample of PMMA from 191 to 1688 nm. Reflection SE data were taken from the polymer surface at three different angles of incidence, where the backside of the sample was roughened prior to these measurements. To model the small absorption of the PMMA, transmission intensity measurements were also obtained with an ellipsometer at normal incidence to the sample surface. Both the reflection and transmission data were reasonably fit using a summation of a Cody-Lorentz oscillator and 14 Gaussian oscillators to account for absorptions in the sample. The optical functions obtained in this work agree well with previously reported values. For example, the authors obtained the following nx values, where x is the wavelength in nanometers, of n300 = 1.528, n500 = 1.492, and n1000 = 1.479.
Evaluation of Centrifugation Technique and Effect of Epinephrine on Fat Cell Viability in Autologous Fat Injection (2009)

Centrifugation with 3000 RPM for 3 minutes is recommended. The effect of epinephrine on fat cell viability is negligible.
Comparative effectiveness of oral anticoagulants in everyday practice (2021)

NCT01090362.
Abstractive Spoken Document Summarization Using Hierarchical Model with Multi-Stage Attention Diversity Optimization (2020)

Abstractive summarization is a standard task for written documents, such as news articles. Applying summarization schemes to spoken documents is more challenging, especially in situations involving human interactions, such as meetings. Here, utterances tend not to form complete sentences and sometimes contain little information. Moreover, speech disfluencies will be present as well as recognition errors for automated systems. For current attention-based sequence-to-sequence summarization systems, these additional challenges can yield a poor attention distribution over the spoken document words and utterances, impacting performance. In this work, we propose a multi-stage method based on a hierarchical encoder-decoder model to explicitly model utterance-level attention distribution at training time; and enforce diversity at inference time using a unigram diversity term. Furthermore, multitask learning tasks including dialogue act classification and extractive summarization are incorporated. The performance of the system is evaluated on the AMI meeting corpus. The inclusion of both training and inference diversity terms improves performance, outperforming current state-of-the-art systems in terms of ROUGE scores. Additionally, the impact of ASR errors, as well as performance on the multitask learning tasks, is evaluated.
Torque ripple reduction in electric machines (2023)

An electric machine, such as an Internal Permanent magnet or Synchronous Reluctance machine, having X phases, that includes a stator assembly, having M slots, with a stator core and stator teeth, that is further configured with stator windings to generate a stator magnetic field when excited with alternating currents and extends along a longitudinal axis with an inner surface that defines a cavity; and a rotor assembly, having N poles, disposed within the cavity which is configured to rotate about the longitudinal axis, wherein the rotor assembly includes a shaft, a rotor core located circumferentially around the shaft. The machine is configured such that a value k=M/(X*N) wherein k is a non-integer greater than about 1.3. The electric machine may alternatively, or additionally, include a non-uniformed gap between the exterior surface of the rotor spokes and the interior stator surface of the stator.
Altered Expression of Type II Sodium/Phosphate Contransporter in Polycystic Kidney Disease (2000)

Renal phosphate (Pi) absorption is mediated via the type II sodium/Pi cotransporter (NaPi-2) in the brush border membrane (BBM) of proximal tubules. Simultaneous detection of NaPi-2 mRNA by in situ hybridization and of NaPi-2 immunoreactivity by immunohistochemistry was performed to investigate the distribution of the cotransporter in healthy control rats and during progression of autosomal dominant polycystic kidney disease (ADPKD). The purpose of the study was to disclose a relation between proximal tubular cell differentiation and NaPi-2 expression. In controls, NaPi-2 expression was present in the entire proximal tubule. In the Han:SPRD (cy/+) model for ADPKD, the proximal nephron is primarily affected by the cystic changes. Epithelial proliferation and impaired epithelial-matrix interaction result in a loss of cell differentiation that eventually leads to cystic enlargement of the nephron. Normal expression of NaPi-2 in this model was found only in tubules with intact BBM. Loss of BBM and cellular interdigitation were paralleled by the loss of NaPi-2 in situ hybridization and immunoreactive signals. These changes were moderate and focal in 2-mo-old rats and generalized all over the cortex after 8 mo. Advanced renal damage in the older PKD group was associated with mild phosphaturia, which suggests functional insufficiency of tubular NaPi-2 reabsorption. These data show how proliferative changes and loss of tubular epithelial differentiation in ADPKD may prevent functional expression of the NaPi-2 system in the proximal tubule in a rapidly progressive manner. NaPi-2 in proximal tubule BBM is suggested to play an important role in impaired tubular absorption of Pi in renal disease.