gebhart/patrepeval huggingface dataset:
TUNED MASS DAMPER DESIGN FOR VIBRATION SUPPRESSION OF STACKER CRANES (2014)

During a normal work cycle, stacker cranes can exhibit large vibration amplitude due to the impulsiveness of the loads to which they are subjected. In order to control and reduce these vibrations, a simple lumped parameter (LP) model of a stacker cranes has been developed. The parameters of the LP have been estimated by means of a more detailed finite element model. The LP model has been used in order to evaluate the effectiveness of a tuned mass damper (TMD) for vibration suppression. The TMD has been tuned by means of the model results. Eventually, a new prototype of a stacker crane has been designed including the TMA.
Purification of Natural Gas by forming H2S Hydrates (2013)

Abstract H 2 S‐hydrate formation is demonstrated as a method for cleaning contaminated natural gas. Not only the final equilibrium cleanup but also the rates of separation attainment are much higher than for CO 2 hydrates. H 2 S concentrates in the hydrate phase and is then depleted from the gas; this was observed at temperatures as high as 15 °C. The shortest batch‐formation times are on the order of 1 min at pressures of approximately 30 bar. Formation times of H 2 S hydrates are considerably shorter than for CO 2 . The supersaturation and mixing speed are the critical parameters as well as maintaining maximum solvation of H 2 S in water throughout the process.
Initial Study on Imaging Cyclic Tissue Motion with Motion Encoding Gradients in the Shape of Wavelet Basic Functions (2023)

The goal of this study was to better detect cyclic motion with multiple frequencies in tissue. A novel MRE technique was developed using motion encoding gradient (MEG) pulses of multiple scales (multi-scale MRE). These MEG pulses were designed and timed to approximate a complete basis of Haar wavelet system. Our hypothesis was that a set of orthogonal MEG pulses can capture the tissue motion more efficiently and tissue motion can be reconstructed by a simple inverse transform. Initial tests were performed on a phantom and a volunteer.
Flexible access to photo libraries via time, place, tags, and visual features (2010)

Photo libraries are growing in quantity and size, requiring better support for locating desired photographs. MediaGLOW is an interactive visual workspace designed to address this concern. It uses attributes such as visual appearance, GPS locations, user-assigned tags, and dates to filter and group photos. An automatic layout algorithm positions photos with similar attributes near each other to support users in serendipitously finding multiple relevant photos. In addition, the system can explicitly select photos similar to specified photos. We conducted a user evaluation to determine the benefit provided by similarity layout and the relative advantages offered by the different layout similarity criteria and attribute filters. Study participants had to locate photos matching probe statements. In some tasks, participants were restricted to a single layout similarity criterion and filter option. Participants used multiple attributes to filter photos. Layout by similarity without additional filters turned out to be one of the most used strategies and was especially beneficial for geographical similarity. Lastly, the relative appropriateness of the single similarity criterion to the probe significantly affected retrieval performance.
Electromagnetic Dampeners to Improve Cavity Shielding Effectiveness. (2019)

Abstract not provided.
Condition Number as a Metric for the Effectiveness of Polarimetric Algorithms (2005)

Condition number is a standard metric used to quantify the effectiveness of polarimetric algorithms. In this work several definitions of condition number are compared, and their utility is illustrated by analyzing various polarimeter configurations.
MICRORNA EXPRESSION PROFILE IN CLEAR-CELL KIDNEY CANCER (2008)

You have accessJournal of Urology1 Apr 2008MICRORNA EXPRESSION PROFILE IN CLEAR-CELL KIDNEY CANCER David Juan, Gabriela Alexe, Travis Antes, David Foran, Anant Madabhushi, Gyan Bhanot, Charles Delisi, Shridar Ganesan, and Louis Liou David JuanDavid Juan More articles by this author , Gabriela AlexeGabriela Alexe More articles by this author , Travis AntesTravis Antes More articles by this author , David ForanDavid Foran More articles by this author , Anant MadabhushiAnant Madabhushi More articles by this author , Gyan BhanotGyan Bhanot More articles by this author , Charles DelisiCharles Delisi More articles by this author , Shridar GanesanShridar Ganesan More articles by this author , and Louis LiouLouis Liou More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60270-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "MICRORNA EXPRESSION PROFILE IN CLEAR-CELL KIDNEY CANCER." The Journal of Urology, 179(4S), p. 92 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 92 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetrics Author Information David Juan More articles by this author Gabriela Alexe More articles by this author Travis Antes More articles by this author David Foran More articles by this author Anant Madabhushi More articles by this author Gyan Bhanot More articles by this author Charles Delisi More articles by this author Shridar Ganesan More articles by this author Louis Liou More articles by this author Expand All Advertisement PDF downloadLoading ...
High-throughput proteomics of nanogram-scale samples with Zeno SWATH MS (2022)

The possibility to record proteomes in high throughput and at high quality has opened new avenues for biomedical research, drug discovery, systems biology, and clinical translation. However, high-throughput proteomic experiments often require high sample amounts and can be less sensitive compared to conventional proteomic experiments. Here, we introduce and benchmark Zeno SWATH MS, a data-independent acquisition technique that employs a linear ion trap pulsing (Zeno trap pulsing) to increase the sensitivity in high-throughput proteomic experiments. We demonstrate that when combined with fast micro- or analytical flow-rate chromatography, Zeno SWATH MS increases protein identification with low sample amounts. For instance, using 20 min micro-flow-rate chromatography, Zeno SWATH MS identified more than 5000 proteins consistently, and with a coefficient of variation of 6%, from a 62.5 ng load of human cell line tryptic digest. Using 5 min analytical flow-rate chromatography (800 µl/min), Zeno SWATH MS identified 4907 proteins from a triplicate injection of 2 µg of a human cell lysate, or more than 3000 proteins from a 250 ng tryptic digest. Zeno SWATH MS hence facilitates sensitive high-throughput proteomic experiments with low sample amounts, mitigating the current bottlenecks of high-throughput proteomics.
Virologic and Immunologic Determinants of Heterosexual Transmission of Human Immunodeficiency Virus Type 1 in Africa (2001)

More than 80% of the world's HIV-infected adults live in sub-Saharan Africa, where heterosexual transmission is the predominant mode of spread. The virologic and immunologic correlates of female-to-male (FTM) and male-to-female (MTF) transmission are not well understood. A total of 1022 heterosexual couples with discordant HIV-1 serology results (one partner HIV infected, the other HIV uninfected) were enrolled in a prospective study in Lusaka, Zambia and monitored at 3-month intervals. A nested case-control design was used to compare 109 transmitters and 208 nontransmitting controls with respect to plasma HIV-1 RNA (viral load, VL), virus isolation, and CD4(+) cell levels. Median plasma VL was significantly higher in transmitters than nontransmitters (123,507 vs. 51,310 copies/ml, p < 0.001). In stratified multivariate Cox regression analyses, the risk ratio (RR) for FTM transmission was 7.6 (95% CI: 2.3, 25.5) for VL > or = 100,000 copies/ml and 4.1 (95% CI: 1.2, 14.1) for VL between 10,000 and 100,000 copies/ml compared with the reference group of <10,000 copies/ml. Corresponding RRs for MTF transmission were 2.1 and 1.2, respectively, with 95% CI both bounding 1. Only 3 of 41 (7%) female transmitters had VL < 10,000 copies/ml compared with 32 of 93 (34%) of female nontransmitters (p < 0.001). The transmission rate within couples was 7.7/100 person-years and did not differ from FTM (61/862 person-years) and MTF (81/978 person-years) transmission. We conclude that the association between increasing plasma viral load was strong for female to male transmission, but was only weakly predictive of male to female transmission in Zambian heterosexual couples. FTM and MTF transmission rates were similar. These data suggest gender-specific differences in the biology of heterosexual transmission.
Synthesis and characterization of polystyrene–poly(ethylene oxide)–heparin block copolymers (1988)

Abstract A procedure for the preparation of new block copolymers composed of a hydrophobic block of polystyrene, a hydrophilic spacer‐block of poly(ethylene oxide) and a bioactive block of heparin was investigated. Polystyrene with one amino group per chain was synthesized by free radical oligomerization of styrene in dimethylformamide, using 2‐aminoethanethiol as a chain transfer agent. This amino group was used in the coupling reaction with amino‐telechelic poly(ethylene oxide) to produce an AB type diblock copolymer with one amino group per polystyrene (PSt)–poly(ethylene oxide) (PEO) chain. The amino‐semitelechelic oligo‐styrene was converted into the isocyanate‐semitelechelic oligo‐styrene using toluene 2,4‐diisocyanate and subsequent coupling with H 2 N–PEO–NH 2 afforded AB type block copolymers with terminal amino groups. The coupling of PSt–PEO–NH 2 with heparin was performed in a DMF–H 2 O mixture, first by activating the heparin carboxylic groups with EDC at pH 5.1–5.2 and subsequently reacting the activated carboxylic groups with the amino groups of the PSt–PEO–NH 2 at pH 7.5. Depending on the molecular weights of the diblock copolymer used 25–29% w/w heparin was incorporated. These polymers will be further evaluated for their blood‐compatibility.
Shared Genomic Alterations in Patients with Co-Existing Myeloproliferative Neoplasms and Angioimmunoblastic T-Cell Lymphoma (2019)

Background: Myeloproliferative neoplasia (MPN) and angioimmunoblastic T-cell lymphoma (AITL) are two distinct hematologic cancers. However, we have shown that patients with both malignancies probably occur with frequencies higher than expected in the background population (1,2). AITL tumors show a high frequency (30-70%) of mutations in RHOA and epigenetic modifier genes such as DNMT3A, TET2 and IDH2. The latter genomic alterations are similar to those found in myeloid diseases such as MPN. This observation has raised questions on whether the two hematologic malignancies may share genomic aberrations (e.g. at progenitor level) suggesting a possible pathogenetic relationship between these diseases. Aim: To further investigate these questions, we explored the mutational landscape in MPN and AITL tumors occurring in the same host. Methods: From a Danish cohort of 97 patients with co-existing MPN and lymphoma identified through the Danish Lymphoma and Pathology Registries and immunohistochemically validated by tertiary center hematopathologists, five patients with MPN and concurrent and/or subsequent AITL were included. Paired DNA samples obtained from lymph node biopsies (AITL component), bone marrow aspirates (MPN component) and saliva specimens (normal reference DNA) were analyzed by whole exome sequencing. A minimum variant allele frequency threshold of 10% was applied. However, mutations in epigenetic modifier genes, RHOA and JAK2, were also included, if found at slightly lower frequencies. Results: Figure 1 shows an overview of the identified mutations. At a VAF% cut-off value of 10 and a median coverage of 30, mutations shared between the MPN and AITL specimens were found within the DNMT3A, TET2, and IDH2 genes. Mutations in the JAK2 gene were identified in all MPN and in some of the AITL samples. NOTCH2 mutations were frequent and some were shared between the MPN and AITL samples. Two patients with essential thrombocytosis and AITL had the same NOTCH2 (C19W) and NCOR1 (K178N) mutation. Most of the identified genomic alterations were inactivating missense mutations. Conclusion: Co-existence of MPN and AITL occurs and may not be a random event. We studied tumor tissues from patients diagnosed with both diseases, and identified recurrent shared and non-shared mutations in samples from both types of cancers. These mutations may contribute to the development of the two malignancies in the same host, partly through common steps at precursor level (e.g. DNMT3A) and partly more downstream at a more lineage-specific level (e.g. IDH2). The functional role of the observed NOTCH2 and NCOR1 mutations is currently under investigation. Holst J et al. Blood 2017, 130 (S1): 1525 Frederiksen H et al. Blood 2011;118(25):6515-6520 Disclosures Tam: Takeda: Consultancy; Paragon Genomics: Consultancy.
Orthogonal time‐of‐flight secondary ion mass spectrometric analysis of peptides using large gold clusters as primary ions (2004)

Secondary ion mass spectrometry (SIMS) for biomolecular analysis is greatly enhanced by the instrumental combination of orthogonal extraction time-of-flight mass spectrometry with massive gold cluster primary ion bombardment. Precursor peptide molecular ion yield enhancements of 1000, and signal-to-noise improvements of up to 20, were measured by comparing SIMS spectra obtained using Au(+) and massive Au(400) (4+) cluster primary ion bombardment of neat films of the neuropeptide fragment dynorphin 1-7. Remarkably low damage cross-sections were also measured from dynorphin 1-7 and gramicidin S during prolonged bombardment with 40 keV Au(400) (4+). For gramicidin S, the molecular ion yield increases slightly as a function of Au(400) (4+) beam fluence up to at least 2 x 10(13) Au(400) (4+)/cm(2). This is in marked contrast to the rapid decrease observed when bombarding with ions such as Au(5) (+) and Au(9) (+). When gramicidin S is impinged with Au(5) (+), the molecular ion yield decreases by a factor of 10 after a fluence of only 8 x 10(12) ions/cm(2). Comparison of these damage cross-sections implies that minimal surface damage occurs during prolonged Au(400) (4+) bombardment. Several practical analytical implications are drawn from these observations.
A study of defect propagation/growth for VLSI manufacturing yield impact prediction (2002)

The transformation of contaminating particles into defects and then electrical faults is a very complex process which depends on the defect location, size, material and the underlying IC topography. A rigorous topography simulator, METROPOLE has been developed to allow the prediction and correlation of the critical physical parameters (material, size and location) of contamination in the manufacturing process to device defects. The results for a large number of defect samples simulated using the above approach were compared with data gathered from the AMD-Sunnyvale fabline. A good match was obtained indicating the accuracy of this method which provided a framework for developing contamination to defect propagation/growth macromodels. We have demonstrated that the understanding of the defect transformation can be applied to early yield impact prediction.
Address Mapping of IPv6 Multicast Packets on Ethernet (2011)

When transmitting an IPv6 packet with a multicast destination address, the IPv6 destination address is mapped to an Ethernet linklayer multicast address. This document clarifies that a mapping of an IPv6 packet with a multicast destination address may in some circumstances map to an Ethernet link-layer unicast address.
Screening for functional kinases in metastatic prostate cancer: a glimmer of hope for kinase inhibition (2016)

Understanding the molecular biology of castration-resistant prostate cancer (CRPC) has led to a dramatic paradigm shift in the treatment of patients with metastatic disease where the androgen receptor (AR) is a central therapeutic target in the disease. Despite these major advances, disease biology and the well-recognized heterogeneity of prostate cancer (PCa) are some of the inherent disease-specific issues that continue to affect clinical trial design, drug development and ultimately patient outcomes.
Respiratory Outcome after Preterm Birth: A Long and Difficult Journey (2016)

Despite notable advances in the survival and management of preterm infants in recent decades, chronic lung disease remains a common complication. Approximately one in three infants born preterm (< 32 weeks of gestation) are hospitalized with respiratory problems (mainly due to infections) in their first 2 years of life, and the risk of childhood wheezing is three times higher in this population. By comparison with infants born at term, there seems to be a higher incidence of respiratory morbidity in those born preterm, even in the absence of bronchopulmonary dysplasia (BPD) and in late-preterm babies. Although long-term follow-up data are still not collected systematically, there is evidence of preterm infants' respiratory symptoms, lung function impairments, and radiological abnormalities, tending to persist throughout childhood and into early adulthood. Respiratory conditions associated with preterm birth are often diagnosed and treated as asthma, but the pathophysiological patterns of BPD and asthma are very different. Future research should focus on characterizing preterm infants' pathological pulmonary features by gestational age at birth, and presence or absence of BPD. Improving our current knowledge of the respiratory disorder associated with prematurity might hopefully prompt targeted follow-up protocols, and novel prevention strategies and treatment approaches.
Gastrointestinal Absorption and Urinary Excretion of trans-Cinnamic and p-Coumaric Acids in Rats (2006)

trans-Cinnamic acid (CIN) and p-coumaric acid (COU) are ingested by humans in their diet. While the metabolism and health benefits of CIN have been widely documented, little is known about its absorption sites, and there have been few studies dedicated to COU. The gastrointestinal sac technique demonstrated that CIN and COU are absorbed by all digestive organs in rats and partially transported via MCT-mediated carrier. Absorption was lowest in the stomach. Regardless of the organs that were studied, CIN was more efficiently absorbed than COU. After their individual oral administration to rats, CIN and COU were excreted in 0-24 h urine (0.3% and 23% of ingested CIN and COU, respectively). This suggests that COU was less metabolized than CIN. CIN and COU are absorbed across the digestive epithelium and subsequently interact with target tissues. Despite its lower gastrointestinal absorption, COU may have greater health benefits because it seems to be less metabolized than CIN.
Gene expression of ASNS, LGMN and CTSB is elevated in a subgroup of childhood BCP‑ALL with PAX5 deletion (2019)

Resistance to L-asparaginase (L-asp) is a major contributor to poor treatment outcomes of several subtypes of childhood B cell precursor acute lymphoblastic leukemia (BCP-ALL). Asparagine synthetase (<i>ASNS</i>), legumain (<i>LGMN</i>) and cathepsin B (<i>CTSB</i>) serve a key role in L-asp resistance. The association between genetic subtypes of BCP-ALL and the expression of <i>ASNS, LGMN</i> and <i>CTSB</i> may elucidate the mechanisms of treatment failure. Bone marrow samples of 52 children newly diagnosed with BCP-ALL were screened for major genetic abnormalities and <i>ASNS, LGMN</i> and <i>CTSB</i> gene expression levels. The cohort was further divided into groups corresponding to the key genetic aberrations occurring in BCP-ALL: Breakpoint cluster region and Abelson murine leukemia viral oncogene homolog 1 fusion; hyperdiploidy, hypodiploidy, ETS variant 6 and runt-related transcription factor 1 fusion and other BCP-ALL with no primary genetic aberration identified. A subgroup analysis based on the differences in copy number variations demonstrated a significant increase of <i>ASNS, LGMN</i> and <i>CTSB</i> median expression in other BCP-ALL cases with paired box 5 (<i>PAX5</i>) deletion (P=0.0117; P=0.0036; P<0.0001, respectively) compared with those with wild-type <i>PAX5</i>. Patients with high <i>ASNS</i> expression exhibited longer relapse-free survival (RFS) compared with those with low <i>ASNS</i> levels (P=0.0315; HR, 0.19; 95% CI, 0.04-0.86); the 5-year RFS for patients in the high <i>ASNS</i> expression group was 90.15% (95% CI, 87.90-92.40%). Despite the impact on <i>ASNS, LGMN</i> and <i>CTSB</i> expression, <i>PAX5</i> deletion did not influence RFS in the other BCP-ALL group (P=0.6839). Therefore, the results of the present study revealed high levels of <i>ASNS, LGMN</i> and <i>CTSB</i> expression in the other BCP-ALL group with concomitant <i>PAX5</i> deletion and no subsequent deterioration in 5-year RFS. High <i>ASNS</i> expression level, as a single factor, was strongly associated with an improved outcome.
Thickening CO2with Direct Thickeners, CO2-in-Oil Emulsions, or Nanoparticle Dispersions: Literature Review and Experimental Validation (2021)

High molecular weight associating random copolymers, such as poly(fluoroacrylate-styrene) (polyFAST), are direct CO2 thickeners that can dissolve readily in CO2 and significantly increase viscosity. Although polyfluoroacrylate (PFA) is more CO2-soluble than polyFAST, PFA induces less thickening because it is non-associating. High molecular weight poly(dimethylsiloxane) (PDMS) and poly(vinyl acetate) (PVAc) can increase CO2 viscosity if toluene cosolvent is introduced. Bis(2-ethylhexyl) sulfosuccinate sodium salt (AOT) can thicken CO2 modestly if ethanol cosolvent is added. Little CO2 thickening has been reported for low molecular weight polymers, including poly(vinyl ethyl ether) (PVEE) and poly-1-decene (P1D). Associating oligomers of poly(propylene oxide) (PPO) with pendant aromatic groups showed modest CO2 viscosity enhancement. Cross-linked phosphate esters can increase the viscosity of CO2 if a very substantial concentration of a light alkane cosolvent is added. Indirect thickening of CO2 involves the generation of high apparent viscosity, completely waterless CO2-in-oil (C/O) emulsions that can be attained when CO2 is mixed with mineral oil containing a silicone-alkyl copolymeric surfactant; similar behavior was observed with a proprietary blend of oil and surfactants. Only one nanoparticle-based thickening of CO2 involving the dispersal of dilute concentrations of nanoparticles that are surface-functionalized with highly CO2-philic groups was reported (however, no explanation was provided to explain how the high molecular weight polymer used in this study could be CO2-soluble). New experimental results were obtained for some readily available or easily synthesized CO2-thickening candidates. PolyFAST yielded very substantial viscosity increases. PFA, PDMS-toluene, and PVAC-toluene could appreciably thicken CO2. Very little detectable viscosity enhancement was achieved with low molecular weight PVEE or P1D. CO2 was thickened slightly with AOT-ethanol. Regarding future studies, novel, nonfluorous associating CO2-philic oligomers, and highly CO2-philic phosphate esters that remain dissolved in CO2 after cross-linking are the most obvious candidates for CO2 direct thickeners.