gebhart/patrepeval huggingface dataset:
Decorrelating Compensation Scheme for Coefficient Errors of a Filter Bank Parallel A/D Converter (2004)

In this letter, a parallel analog-digital (A/D) conversion scheme with a filter bank for low intermediate-frequency receivers is presented. The analysis filters of the filter bank divide the frequency components of the received signal, and achieve parallel A/D conversion. Therefore, the required conversion rates and the resolution of the A/D converters can be reduced and the receiver can demodulate wideband signals. As the analysis filters consist of analog components, their coefficients include errors. These errors cause mutual interference between signals in orthogonal frequencies. In order to remove this interference, a decorrelating compensation scheme is proposed.
Synthese und In‐vivo‐Bildgebung eines 18F‐markierten PARP1‐ Inhibitors mithilfe eines chemisch orthogonalen, Abfangreagens‐ gestützten Hochdurchsatzverfahrens (2011)

Schneller zum Ziel: Ein durch katalysatorfreie Diels-Alder-Cycloaddition zwischen trans-Cycloocten und Tetrazin schnell und selektiv aus seiner Tetrazin-konjugierten Vorstufe hergestelltes 18F-markiertes AZD2281-Derivat wurde in biologischen Assays erfolgreich getestet, und seine gezielte Anreicherung wurde in vivo nachgewiesen. Das Verfahren steigert durch die Parallelsynthese potenzieller PET-Tracer die Effizienz der Leitstrukturentwicklung.
Case report – Asterixis Post High Frequency Focused-Ultrasound Thalamotomy (2022)

Although asterixis has been associated with thalamic infarcts in the past, this has not yet been reported in the literature with MRgFUS procedure and is a novel observation. Occupational and physical therapy may be considered to address this side effect. It is important to counsel patients about the rare occurrence of this complication of therapy but also its potential for complete resolution over time.
Surface Modification of Liposomes by a Lipopolymer Targeting Prostate Specific Membrane Antigen for Theranostic Delivery in Prostate Cancer (2019)

Prostate specific membrane antigen (PSMA) is a marker for diagnosis and targeted delivery of therapeutics to advanced/metastasized prostate cancer. We report a liposome-based system for theranostic delivery to PSMA-expressing (PSMA⁺) LNCaP cells. A lipopolymer (P³) comprising of PSMA ligand (PSMAL), polyethylene glycol (PEG<sub>2000</sub>), and palmitate was synthesized and post-inserted into the surface of preformed liposomes. These P³-liposomes were loaded with doxorubicin and radiolabeled with <sup>99m</sup>Tc radionuclide to study their theranostic characteristics. Differential expression of PSMA on LNCaP and PC3 cells was confirmed by immunoblotting as well as by uptake of PSMAL labeled with <sup>18</sup>F radionuclide. We found that the uptake of <sup>99m</sup>Tc-labeled P³-liposomes by LNCaP cells was >3-fold higher than <sup>99m</sup>Tc-labeled Plain-liposomes; the amount of doxorubicin delivered to LNCaP cells was also found to be >3-fold higher by P³-liposomes. Cell-based cytotoxicity assay results showed that doxorubicin-loaded P³-liposomes were significantly more toxic to LNCaP cells (<i>p</i> < 0.05), but not to PSMA-negative PC3 cells. Compared to doxorubicin-loaded Plain-liposomes, the IC<sub>50</sub> value of doxorubicin-loaded P³-liposomes was reduced by ~5-fold in LNCaP cells. Together, these results suggest that surface functionalization of liposomes with small PSMA-binding motifs, such as PSMAL, can provide a viable platform for specific delivery of theranostics to PSMA⁺ prostate cancer.
Prediction of Rate of Penetration of Deep and Tight Formation Using Support Vector Machine (2018)

Abstract Rate of penetration (ROP) is the main function that affects drilling operation economically and efficiently. Many theoretical models reported in the literature were produced to predict ROP based on different parameters. Most of these models used only drilling parameters to estimate ROP. Few models have considered the effects of drilling fluid on ROP using a simulated data or a few real field data. Some of the researchers used artificial intelligence to predict ROP by only one method. The objective of this research is to predict ROP based on both drilling parameters and mud properties such as weight on bit (WOB), rotary speed (RPM), pump flow rate (Q), standpipe pressure (SPP), drilling torque (τ), mud density (MW), plastic viscosity (PV), funnel viscosity (FV), yield point (YP) and solid (%). More than 400 real field data in shale formation are used to predict ROP using support vector machine (SVM) which is a method of artificial intelligence (AI) and compare it with different mathematical models. The result showed that support vector machine (SVM) technique outperformed all the theoretical equations of ROP by a high margin as shown by a very high correlation coefficient (CC) of 0.997 and a very low average absolute percentage error (AAPE) of 2.83%.
Multiattribute probabilistic prostate elastic registration (MAPPER): Application to fusion of ultrasound and magnetic resonance imaging (2015)

MAPPER aligns MRI and TRUS imagery without manual intervention ensuring efficient, reproducible registration. MAPPER has a similar RMSE to state-of-the-art methods that require manual intervention.
Inhibitory Effects of Different Retinoids (Vitamin A Analogues) on the Stimulated Rat Liver Guanylate Cyclase Activity (1982)

Vitamin A and its analogues show the ability to prevent malignant cell transformation on induction with different carcinogens, such as nitrosamines. Cyclic GMP has been proposed as a positive modulator of malignant cell growth and the cGMP-forming enzyme guanylate cyclase is strongly stimulated by e.g. nitrosamines. In this study, we found that retinylacetate and retinal were very potent inhibitors of the stimulated guanylate cyclase. When a series of structurally different retinoids were tested in the same system, a wide range of inhibitory activity on guanylate cyclase was found for the different retinoids with some being completely ineffective. The most potent inhibitor was retinylacetate. Furthermore, the inhibitory profile of the retinoids on the guanylate cyclase did not seem to correlate to their in vivo activity as antineoplastic agents, as described in the literature. We therefore conclude that there does not exist a general connection between the anticancer activity and the guanylate cyclase inhibition of the retinoids. However, it can not be excluded that the guanylate cyclase inhibition might be of importance for the antineoplastic activity for some of the retinoids.
Impact of Geometry on the TM Photonic Band Gaps of Photonic Crystals and Quasicrystals (2011)

Here we demonstrate a novel quantitative procedure to pursue statistical studies on the geometric properties of photonic crystals and photonic quasicrystals (PQCs) which consist of separate dielectric particles. The geometric properties are quantified and correlated to the size of the photonic band gap (PBG) for wide permittivity range using three characteristic parameters: shape anisotropy, size distribution, and feature-feature distribution. Our concept brings statistical analysis to the photonic crystal research and offers the possibility to predict the PBG from a morphological analysis.
ChemInform Abstract: Diphenylboryldipivaloylphosphide ‐ The First Example of Borylated 2‐ Phospha‐1,3‐dionate. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Preparation of Three Dimensionally Ordered Macroporous LiCoO<sub>2</sub> Cathode for Lithium Batteries (2007)

Macroporous LiCoO2 was prepared by a colloidal crystal templating method. Colloidal crystal consisting of monodisperse polystyrene particles was used as the template for the synthesis of macroporous LiCoO2. A Li-Co-O sol was injected into the template, and it was calcined at high temperatures. A porous membrane of LiCoO2 with three dimensionally ordered macroporous (3DOM) structure was obtained. The prepared material had a rock-salt type crystallographic structure with R3m space group. The interconnected macropores with relative uniform size (0.8~0.9 ;m) were observed on entire part of the membrane. The electrochemical properties of the 3DOM LiCoO2 were characterized with galvanostatic charge-discharge measurements in an organic electrolyte containing a lithium salt. The 3DOM LiCoO2 exhibited charge and discharge capacities of 136 and 107 mA h g-1, respectively, at around 3.9 V vs. Li/Li+, indicating that 3DOM LiCoO2 electrode had solid state redox reaction accompanying with Li+ ion insertion and extraction to CoO2 frameworks.
Fabrication of Functional Cardiac, Skeletal, and Smooth Muscle Pumps In Vitro (2010)

Cardiovascular disease is one of the leading causes of death in the United States, and new treatments need to be developed in order to provide novel therapies. Tissue engineering aims to develop biologic substitutes that restore tissue function. The purpose of the current study was to construct cell-based pumps, which can be viewed as biologic left ventricular assist devices. The pumps were fabricated by culturing cardiac, skeletal, and smooth muscle cells within a fibrin gel and then each 3-D tissue construct was wrapped around a decellularized rodent aorta. We described the methodology for pump fabrication along with functional performance metric, determined by the intra-luminal pressure. In addition, histologic evaluation showed a concentric organization of components, with the muscle cells positioned on the outermost surface, followed by the fibrin gel and the decellularized aorta formed the innermost layer. Though early in development, cell-based muscle pumps have tremendous potential to be used for basic and applied research, and with further development, can be used clinically as cell-based left ventricular assist devices.
Design and Analysis of Hardware-limited Non-uniform Task-based Quantizers (2022)

Hardware-limited task-based quantization is a new design paradigm for data acquisition systems equipped with serial scalar analog-to-digital converters using a small number of bits. By taking into account the underlying system task, task-based quantizers can efficiently recover the desired parameters from the low-bit quantized observation. Current design and analysis frameworks for hardware-limited task-based quantization are only applicable to inputs with bounded support and uniform quantizers with non-subtractive dithering. Here, we propose a new framework based on generalized Bussgang decomposition that enables the design and analysis of hardware-limited task-based quantizers that are equipped with non-uniform scalar quantizers or that have inputs with unbounded support. We first consider the scenario in which the task is linear. Under this scenario, we derive new pre-quantization and post-quantization linear mappings for task-based quantizers with mean squared error (MSE) that closely matches the theoretical MSE. Next, we extend the proposed analysis framework to quadratic tasks. We demonstrate that our derived analytical expression for the MSE accurately predicts the performance of task-based quantizers with quadratic tasks.
An O(n) algorithm for transistor stacking with performance constraints (2005)

We describe a new constraint-driven stacking algorithm for diffusion area minimization of CMOS circuits. It employs an Eulerian trail finding algorithm that can satisfy analog-specific performance constraints. Our technique is superior to other published approaches both ill terms of its time complexity and in the optimality of the stacks it produces. For a circuit with n transistors. The time complexity is O(n). All performance constraints are satisfied and, for a certain class of circuits, optimum stacking is guaranteed.
ChemInform Abstract: A Formal Synthesis of (‐)‐Pumiliotoxin C. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
GaN Light-Emitting Triodes for High-Efficiency Hole Injection (2006)

A new type of light-emitting device, the light-emitting triode (LET) is demonstrated to have enhanced hole-injection efficiency. The LET has an additional anode to accelerate carriers in the lateral direction by means of an electric field between the two anodes. Theoretical calculations reveal that the lateral electric field provides additional energy to carriers, thereby allowing them to overcome barriers and increasing the carrier injection efficiency into the active region. It is experimentally shown that the light-output power of the LET increases with increasing negative bias to the additional anode, which is fully consistent with the expectation. (c) 2006 The Electrochemical Society.
Synergistic Anti-Tumor Effect of Combining Selective CDK7 and BRD4 Inhibition in Neuroblastoma (2022)

The combination of CDK7 and BRD4 inhibition provides a therapeutic option for neuroblastoma and suggests that the addition of YKL-5-124 could improve the therapeutic efficacy of JQ1 and delay resistance to BRD4 inhibition.
An analysis of a clear-view angelfish bubble-domain shift register (1972)

A clear-view display and printing device is proposed utilizing a new bubble-domain shift register which has triangular patterns etched into the surface of a magnetic crystal. The geometrical and materials requirements for the clear-view shift register are analyzed. The etched-out triangular pattern is shown to provide the unidirectionality of bubble motion under an oscillating bias field just as the triangular Permalloy overlay does. An etched depth of one-tenth of the plate thickness and an etched gradient of about unity are shown to be sufficient for the expected shift-register operation.
Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress (2014)

Some gene deletions or mutations have little effect on metabolism and metabolic adaptation because of redundancy and/or compensation in metabolic pathways. The mechanisms for redundancy and/or compensation in metabolic adaptation in mammalian cells are unidentified. Here, we show that in mouse muscle and myogenic cells, compensatory regulation of the histone deacetylase (HDAC5) transcriptional repressor maintains metabolic integrity. HDAC5 phosphorylation regulated the expression of diverse metabolic genes and glucose metabolism in mouse C2C12 myogenic cells. However, loss of AMP-activated protein kinase (AMPK), a HDAC5 kinase, in muscle did not affect HDAC5 phosphorylation in mouse skeletal muscle during exercise, but resulted in a compensatory increase (32.6%) in the activation of protein kinase D (PKD), an alternate HDAC5 kinase. Constitutive PKD activation in mouse C2C12 myogenic cells regulated metabolic genes and glucose metabolism. Although aspects of this response were HDAC5 phosphorylation dependent, blocking HDAC5 phosphorylation when PKD was active engaged an alternative compensatory adaptive mechanism, which involved post-transcriptional reductions in HDAC5 mRNA (-93.1%) and protein. This enhanced the expression of a specific subset of metabolic genes and mitochondrial metabolism. These data show that compensatory regulation of HDAC5 maintains metabolic integrity in mammalian cells and reinforces the importance of preserving the cellular metabolic adaptive response.
Airway Wall Thickness Assessed Using Computed Tomography and Optical Coherence Tomography (2008)

OCT can be used to measure airway wall dimensions. OCT may be more sensitive at detecting small airway wall changes that lead to FEV(1) changes in individuals with obstructive airway disease.
Topical Immunotherapy of Alopecia Areata: A Large Retrospective Study (2018)

Topical immunotherapy in patients with AA is quite effective, mostly well tolerated, and provides prolonged therapeutic benefits.
Defective Interfering Particles of Poliovirus I. Isolation and Physical Properties (1971)

A class of defective interfering (DI) poliovirus particles has been identified. The first was found as a contaminant of a viral stock; others have been isolated by serial passage at a high multiplicity of infection. The DI particles are less dense than standard virus and sediment more slowly. Their ribonucleic acid (RNA) sediments more slowly than standard RNA and has a higher electrophoretic mobility. Competition hybridization experiments with double-stranded viral RNA indicate that DI RNA is 80 to 90% of the length of standard RNA. The proteins of DI particles are indistinguishable from those of standard poliovirus.
<title>Ophthalmic diagnostics using optical coherence tomography</title> (1993)

We present a new technique for coherent optical imaging of ocular structure based on optical coherence tomography (OCT). OCT is a noncontact, noninvasive, tomographic imaging technique with superior spatial resolution to ultrasound (&lt; 20 micrometers ) and high sensitivity (100 dB dynamic range). We have used OCT to perform direct imaging of ocular structure in the anterior and posterior segments of human eyes in vitro and in vivo. In the anterior segment, we have measured corneal thickness and profile, anterior chamber depth and angle, and iris thickness and profile. These and other possible measurements have potential applications in diagnosis of pathologies of the cornea, angle, and iris, as well as in noncontact biometry for applications in cataract and corneal refractive surgeries. In the posterior segment, we have obtained high-resolution images of retinal structure in human subjects in vivo. These images demonstrate higher resolution than available with any other existing technique, and include characterization of optic disk morphology and topology. These measurements have potential applications in early diagnosis and assessment of glaucoma and other retinal diseases.
Low power 3D MEMS optical switches (2009)

Optical switching is a low power, low cost solution to the need for higher capacity switching. We review optical architectures and review interesting design aspects of 3D MEMS switches and their impact on overall switch performance.
Stabilization, Isomerization and Rearrangement of Enyne [4 + 4]-Cycloadducts (2014)

Reactive 1,2,5-cyclooctatrienes, formed by photocycloaddition of 2-pyridones with enynes, are stabilized by steric shielding, slowing or preventing an otherwise facile [2 + 2]-dimerization reaction. Diisopropylsilyl ether-tethered reactants paired with an alkene substituent (R) produce allenes that are stable (R = TMS) or that isomerize to 1,3-dienes by hydrogen migration (R = alkyl). Under acidic conditions, hydrolysis of the photoproduct's silyl ether can lead to a [3,3]-sigmatropic rearrangement.
Muon radiography employing the DIRC principle for density change measurements under volcanoes and fluid reservoirs (2020)

Mapping the density distribution and monitoring density changes under volcanoes and geological reservoirs is a major challenge in geology and volcanology. Muon radiography has a high potential to advance this field, but often there are no inexpensive high-end detectors available that are suitable for field installations. A DIRC-type Cherenkov detector as a muon camera has a small dimension and is suited for such field applications (MagmaDIRC idea). In measuring directions and energies of the incoming muons one can turn the mass density integrals along the lines of flight into a radiography image, and by discarting low-energy muons with their blurred angular information one obtains sharper images. In particular one may detect the time variation of the mass density distributions situated above the horizon line in a volcanic edifice that occurs when magma is filling its plumbing system or when the level of a lava lake changes. Using numerical simulations, we discuss design aspects and the requirements of such a DIRC system. Two sites are identified for proof-of-principle field measurements. The required measurement times are estimated for the given site conditions and morphology based on the specifications of an operational DIRC system. The merits of DIRC sensors are contrasted to other muon radiography techniques.
Self-collimation in photonic crystal structures: a new paradigm for applications and device development (2007)

In this paper, we report on the development of the self-collimation phenomenon in photonic crystal structures for integrated optics applications. In addition, detailed numerical analysis, design procedures, fabrication and characterization techniques are included. Applications presented in this paper include: channelless waveguiding, orthogonal bending of light, tunable beam splitter, all-optical analog-to-digital converter, reconfigurable optical switch, chemical/gas sensor and a three-dimensional optical interconnect bus.
Additional file 11; of Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals (2016)

Raw data for Fig. S2. (XLSX 48 kb)
Increase in spin injection efficiency of a CoFe∕MgO(100) tunnel spin injector with thermal annealing (2005)

Postgrowth thermal annealing of a CoFe∕MgO(100) tunnel spin injector grown on aGaAs∕AlGaAs quantum well structure results in a significantly increased spin injection efficiency as inferred from the polarization of heavy-hole electroluminescence from a quantum well optical detector. The as-deposited sample displayed an initial polarization at 100K of 43%, which was increased to 52% after a 1h anneal at 300°C, and finally to 55% after a second 1h anneal at 340°C. The polarization remained unchanged upon further annealing to temperatures as high as 400°C. These results show that tunnel spin injectors based on CoFe∕MgO are robust with high thermal stability, making them useful for device applications.
Two-Step Random Access in 5G New Radio: Channel Structure Design and Performance (2021)

A common design of the random access procedure on the physical random access channel (PRACH) is required for the diverse usage scenarios in the fifth generation new radio (5G NR) mobile networks. Based on the latest 3GPP specifications and evaluation assumptions agreed for Release 16, the 2 step-RACH (2SR) enhancement, composed of the denoted MsgA and MsgB, not only reduces the latency but also the control-signalling overhead due to the reduced number of messages transmitted. The channel structure of MsgA comprises RACH preamble and data in the physical uplink shared channel (PUSCH) while MsgB combines the random access response and the contention resolution. This procedure should operate in local area (LA), medium range (MR) and wide area (WA) cells despite the lack of time alignment (TA) in the PUSCH part of MsgA. The demodulation performance degradation observed without time offset compensation at the base station (gNB), specially for MR or WA cells, highlight that practical gNB implementations relying in MAC control element-based TA command for PUSCH time alignment are not conceivable for 2SR. Furthermore, in the case that all preambles from multiple users (UEs) trying to perform the initial access are mapped to the same PUSCH physical resources, the associated data parts overlap and may result in unsuccessful decoding. There is therefore a trade-off between the collision probability of the PUSCH part of MsgA and the resource overhead for 2SR. This paper addresses the channel structure design of this procedure for the preamble and data parts of MsgA together with the receiver processing framework. The performance results suggest that using lower payload sizes provide higher resource utilization and allow more UEs to be multiplexed within the same PUSCH occasion. In addition, using different DMRS ports for UEs sharing same physical resources decrease the probability of failure in the decoding of the data part of MsgA while reduces the resource overhead for 2SR.