gebhart/patrepeval huggingface dataset:
Paclitaxel-Coated Balloons: Investigation of Drug Transfer in Healthy and Atherosclerotic Arteries – First Experimental Results in Rabbits at Low Inflation Pressure (2016)

Atherosclerotic lesions impede the transfer of paclitaxel into arterial walls. Higher inflation pressures resulted in an increased paclitaxel transfer in atherosclerotic but not in healthy arteries. However, it is assumed that the tissue concentrations achieved with an inflation pressure of 2 atm are potentially effective in this model.
The Basic Science of Articular Cartilage: Structure, Composition, and Function (2009)

Articular cartilage is the highly specialized connective tissue of diarthrodial joints. Its principal function is to provide a smooth, lubricated surface for articulation and to facilitate the transmission of loads with a low frictional coefficient (Figure 1). Articular cartilage is devoid of blood vessels, lymphatics, and nerves and is subject to a harsh biomechanical environment. Most important, articular cartilage has a limited capacity for intrinsic healing and repair. In this regard, the preservation and health of articular cartilage are paramount to joint health.



Figure 1.

Gross photograph of healthy articular cartilage in an adult human knee.



Injury to articular cartilage is recognized as a cause of significant musculoskeletal morbidity. The unique and complex structure of articular cartilage makes treatment and repair or restoration of the defects challenging for the patient, the surgeon, and the physical therapist. The preservation of articular cartilage is highly dependent on maintaining its organized architecture.
Immunohistochemical Localization of Multispecific Renal Organic Anion Transporter 1 in Rat Kidney (1999)

Renal proximal convoluted tubules have an important role, i.e., to excrete organic anions, including numerous drugs and endogenous substances. Recently, multispecific organic anion transporter 1 (OAT1) was isolated from rat kidney. In this study, the cellular and subcellular localization of OAT1 in rat kidney was investigated. Kidneys from normal rats were perfused and fixed with periodate-lysine-paraformaldehyde solution and were then processed for immunohistochemical analysis using the labeled streptavidin-biotin method, preembedding horseradish peroxidase method, and immunogold method. Light microscopic examination revealed immunostaining for OAT1 in the middle portion of the proximal tubule (S2 segment), but not in the initial portion of the proximal convoluted tubule, next to the glomerulus. Nephron segments other than the S2 segment and the renal vasculature were not stained with antibody to OAT1. Electron-microscopic observation using a preembedding method revealed that OAT1 was exclusively expressed in the basolateral membrane of S2 segments of proximal tubules. The immunogold method showed no labeling for OAT1 in the cytoplasmic vesicles, suggesting that OAT1 may not move together with organic anions into the cells. These results are consistent with previous physiologic data showing that organic anions, including para-aminohippurate, are taken up by the basolateral Na+-independent organic anion/dicarboxylate exchanger and excreted at S2 segments. In conclusion, OAT1 was localized to the basolateral membrane of S2 segments of proximal tubules in rat kidneys.
An Energy Efficient and Accurate Slot Synchronization Scheme for Wireless Sensor Networks (2006)

Existing slotted channel access schemes in wireless networks assume that slot boundaries at all nodes are synchronized. In practice, relative clock drifts among nodes cause slot misalignment over time and can result in catastrophic data loss in such systems. We propose a simple network-wide slot synchronization scheme (Slot-Sync and Slot-Resync) suitable for duty-cycling wireless sensor networks. The proposed scheme attains high accuracy by circumventing dominant sources of error inherent in traditional time synchronization protocols. At moderate duty-cycle frequencies, the proposed scheme also has the unique advantage of eliminating re-synchronization (re-sync) overhead completely, thereby achieving slot re-sync essentially for free. We provide an energy efficient slot guard time and re- sync interval design for the proposed scheme and analyze several spanning tree structures for slot-alignment message propagation. In addition, we derive upper bounds on the synchronization (sync) error for a family of trees. Through simulations, we compare the spanning trees we propose to those used for time sync in literature and show up to 80% reduction in sync error and up to 70% reduction in energy needed for slot-alignment message propagation by choosing appropriate tree structures.
Fast-Light For Enhanced-Sensitivity White-Light Resonant Interferometry (2006)

A fast-light medium placed inside a resonant interferometer can be used to enhance its sensitivity significantly. At the same time, the linewidth of the cavity resonance can be highly augmented without sacrificing the cavity build-up.
CoDef (2013)

Large-scale botnet attacks against Internet links using low-rate flows cannot be effectively countered by any of the traditional rate-limiting and flow-filtering mechanisms deployed in individual routers. In this paper, we present a collaborative defense mechanism, called CoDef, which enables routers to distinguish low-rate attack flows from legitimate flows, and protect legitimate traffic during botnet attacks. CoDef enables autonomous domains that are uncontaminated by bots to collaborate during link flooding attacks and reroute their customers' legitimate traffic in response to requests from congested routers. Collaborative defense using multi-path routing favors legitimate traffic while limiting the bandwidth available to attack traffic at a congested link. We present CoDef's design and evaluate its effectiveness by exploring the domain-level path-diversity of the Internet and performing simulations under various traffic conditions.
Preclinical Testing of the Nitroimidazopyran PA-824 for Activity against Mycobacterium tuberculosis in a Series of In Vitro and In Vivo Models (2005)

This study extends earlier reports regarding the in vitro and in vivo efficacies of the nitroimidazopyran PA-824 against Mycobacterium tuberculosis. PA-824 was tested in vitro against a broad panel of multidrug-resistant clinical isolates and was found to be highly active against all isolates (MIC<1 microg/ml). The activity of PA-824 against M. tuberculosis was also assessed grown under conditions of oxygen depletion. PA-824 showed significant activity at 2, 10, and 50 microg/ml, similar to that of metronidazole, in a dose-dependent manner. In a short-course mouse infection model, the efficacy of PA-824 at 50, 100, and 300 mg/kg of body weight formulated in methylcellulose or cyclodextrin/lecithin after nine oral treatments was compared with those of isoniazid, rifampin, and moxifloxacin. PA-824 at 100 mg/kg in cyclodextrin/lecithin was as active as moxifloxacin at 100 mg/kg and isoniazid at 25 mg/kg and was slightly more active than rifampin at 20 mg/kg. Long-term treatment with PA-824 at 100 mg/kg in cyclodextrin/lecithin reduced the bacterial load below 500 CFU in the lungs and spleen. No significant differences in activity between PA-824 and the other single drug treatments tested (isoniazid at 25 mg/kg, rifampin at 10 mg/kg, gatifloxacin at 100 mg/kg, and moxifloxacin at 100 mg/kg) could be observed. In summary, its good activity in in vivo models, as well as its activity against multidrug-resistant M. tuberculosis and against M. tuberculosis isolates in a potentially latent state, makes PA-824 an attractive drug candidate for the therapy of tuberculosis. These data indicate that there is significant potential for effective oral delivery of PA-824 for the treatment of tuberculosis.
Magnetic composite nanomaterials for water treatment applications (2020)

A series of novel zeolitic imidazolate framework (ZIF) decorated superparamagnetic graphene oxide hybrid nanoadsorbents were synthesized, characterized, and tested for their As(III) adsorbed amount in simulated drinking water. A series of three ZIFs with zinc (ZIF-8), cobalt (ZIF-67) and mixed zinc/cobalt cores (ZIF-Zn/Co) was studied. The three composite nanomaterials, namely C-1
OHMi-Nunavik: a multi-thematic and cross-cultural research program studying the cumulative effects of climate and socio-economic changes on Inuit communities (2018)

&lt;p&gt;L’adaptation aux changements climatiques et socio-environnementaux est devenue un enjeu majeur pour de nombreuses sociétés, notamment dans l’Arctique. De nombreux Inuit souhaitent mieux comprendre les changements qui se produisent. En 2013, un Observatoire international sur les interactions Homme-Milieu (OHMi) a été mis en place au Nunavik pour identifier ces changements, étudier leur impact cumulatif sur le socio-écosystème et pour aider à élaborer des mesures d’adaptation afin d’améliorer le bien-être des communautés inuit. À cette fin, une équipe d’universitaires et de partenaires Inuit locaux ont uni leurs forces pour développer un programme de recherche concerté, intégré et interdisciplinaire. En utilisant une approche de recherche-action participative, l’OHMi Nunavik a défini les priorités de recherche suivantes: transmission des connaissances entre les aînés et les jeunes, agriculture nordique, préservation de la culture, de la langue et de l’identité inuit, aires protégées, emplois dans les mines, risques naturels et vulnérabilité de la faune. En renforçant les collaborations entre les équipes de recherche multidisciplinaires canadiennes et françaises, le programme de l’OHMi Nunavik intègre les connaissances locales et scientifiques dans la planification de la recherche et la diffusion des résultats.&lt;/p&gt;&lt;h2&gt;Abstract&lt;/h2&gt;&lt;p&gt; Adjusting to global climate and socio-environmental changes has become a major issue for many societies, especially in the Arctic. Many Inuit wish to better understand the changes taking place. In 2013, an international Observatory of Human–Environment Interactions (OHMi) was established in Nunavik to identify these changes, study their cumulative impact on the socio-ecosystem and to help develop adaptation measures to improve the well-being of Inuit communities. To this end, a team of academics and local Inuit partners joined forces to develop an integrated, interdisciplinary, collaborative research program. Using a participatory action research (PAR) approach, the OHMi Nunavik set the following research priorities: elder-youth knowledge transmission, northern agriculture, preservation of Inuit culture, language and identity, protected areas, mining employment, natural hazards and risks, and wildlife vulnerability. By strengthening the collaborations between multidisciplinary Canadian and French research teams, the OHMi Nunavik program integrates local and scientific knowledge both in planning the research and in disseminating the results.&lt;/p&gt;
Serum nitrotyrosine and psychometric tests as indicators of impaired fitness to drive in cirrhotic patients with minimal hepatic encephalopathy (2013)

Impaired mental processing speed, attention and alterations in visuo-spatial and motor coordination seem main contributors to impaired driving ability in patients with MHE. Increased serum 3-nitrotyrosine is associated with impaired driving ability.
DOEs for Color Correction in Broad Band Optical Systems: Validity and Limits of Efficiency Approximations (2010)

Based on design examples of optical systems with DOEs for color correction, limits of diffraction efficiency approximations are discussed. These formulae enable optical designers to estimate the amount of stray light from unwanted diffraction orders.
Inelastic Stress Relaxation in Single Crystal SiC Substrates (2004)

Abstract. Optical methods were used to measure thermal deformations in commercial 4H- and 6H-SiC wafers. In general, during thermal excursions to 500 o C, the radii of curvature of the wafers increased (i.e., the wafers became less bowed). Upon cooling to room temperature, nearly all the wafers retained the high temperature radius of curvature values, a characteristic of thermoplastic deformation. Further cyclic excursions to 500 o C did not yield any significant changes in the radii of curvature, thus signifying the irreversibility of the thermal deformation. The magnitude of the relieved stress following thermal deformation at 500 o C was estimated to be up to 2.14 MPa. Also observed was a significant difference in the thermoplastic deformation between the off- and on-axis wafers of both polytypes, with the former having more deformation (∆R > 3 m) than the latter (∆R < 2 m). An on-axis n-type 6H-SiC that was subjected to thermal cycling to 900 o C in vacuum also exhibited thermoplastic deformation, with an activation energy of 3.14± 0.8 eV and a relieved stress magnitude of 5.67 MPa.
A Multichannel Integrated Circuit for Electrical Recording of Neural Activity, With Independent Channel Programmability (2012)

Since a few decades, micro-fabricated neural probes are being used, together with microelectronic interfaces, to get more insight in the activity of neuronal networks. The need for higher temporal and spatial recording resolutions imposes new challenges on the design of integrated neural interfaces with respect to power consumption, data handling and versatility. In this paper, we present an integrated acquisition system for in vitro and in vivo recording of neural activity. The ASIC consists of 16 low-noise, fully-differential input channels with independent programmability of its amplification (from 100 to 6000 V/V) and filtering (1-6000 Hz range) capabilities. Each channel is AC-coupled and implements a fourth-order band-pass filter in order to steeply attenuate out-of-band noise and DC input offsets. The system achieves an input-referred noise density of 37 nV/√Hz, a NEF of 5.1, a CMRR > 60 dB, a THD < 1% and a sampling rate of 30 kS/s per channel, while consuming a maximum of 70 μA per channel from a single 3.3 V. The ASIC was implemented in a 0.35 μm CMOS technology and has a total area of 5.6 × 4.5 mm². The recording system was successfully validated in in vitro and in vivo experiments, achieving simultaneous multichannel recordings of cell activity with satisfactory signal-to-noise ratios.
An intuitive tool for outlining objetcs in video sequences: applications to augmented and diminished reality (2001)

Colloque avec actes et comité de lecture. internationale.
Patch-based Thermodynamic Property Models for the Subcritical Region (2021)

Model-based design approaches for vapor-compression cycles depend heavily upon refrigerant property representations that are fast, accurate, and consistent. We describe an approach based upon B-spline interpolants that describes properties such as density, temperature, and specific entropy as the intersection of multiple surfaces, which are referred to as ”patches.” When combined with a transformation of thermodynamic coordinates, this approach can calculate the density over a domain with a maximum absolute percentage error less than ×1P− and a speedup over REFPROP of greater than 100x.
Design of stable wireless sensor network for slope monitoring (2018)

This paper presents implementation report for slope monitoring on Wireless Sensor Network (WSN) system by use of IEEE802.15.4 (ZigBee). The purpose of this research is the construction of WSN system which can be sensing and monitoring the deformation of the ground caused by heavy rain in mountain areas with radio communication devices and sensor devices. For the stable data acquisition, some electrical and environmental problems should be solved. In this paper, the techniques for dynamical transition of the communication mode depending on battery capacity, a method of protecting wireless nodes from the lighting, and a optimized design of antenna for WSN are proposed. The experimental results which the proposed system installed at actual test field show that the dynamic wireless network configuration. Moreover, the status of field can be predicted by the obtained data from the improved system.
HYPOLED – VGA OLED micro-display for HMD and micro-projection (2009)

HYPOLED is a collaborative European project that commenced in 2008. It is targeted toward "High-Performance OLED-Microdisplays for Mobile Multimedia HMD and Projection Applications". In this paper, we describe the initial objectives and present draft specifications for devices, the personal display system and micro-projection unit. Initial results are shown and discussed.
A novel β-glucan produced by Paenibacillus polymyxa JB115 induces nitric oxide production in RAW264.7 macrophages (2009)

The effect of extracellular beta-(1-->3), (1-->6)-glucan, produced by Paenibacillus polymyxa JB115, on nitric oxide (NO) production in RAW264.7 macrophages was investigated. beta-glucan induced the production of NO by RAW264.7 macrophages in a concentration- and time-dependent manner. Moreover, beta-glucan stimulation increased the mRNA expression of iNOS, COX-2 and IL-6 in RAW264.7 macrophages in a concentration-dependent manner.
Cell‐Compatible, Multicomponent Protein Arrays with Subcellular Feature Resolution (2008)

Microscale direct writing (MDW) technology is developed for the generation of complex extracellular Matrix (ECM) protein arrays at subcellular feature size with multiple components. Cell-compatible, two-component ECM protein arrays with a feature size of 6–9 micrometers (see image) are systematically generated with varying spacing and composition, and their effects on cellular attachment and spreading of a model cell line, mouse myofibroblasts, are evaluated.
Use of a New Myocardial Centroid for Measurement of Regional Myocardial Dysfunction by Electron Beam Computed Tomography (2001)

In asymmetrically contracting left ventricles, the new myocardial centroid algorithm is superior to conventional methods for tomographic analysis of regional myocardial function.
Two-photon microfabrication using two-component photoinitiation systems: effect of photosensitizer and acceptor concentrations (2003)

Two-photon induced photopolymerization allows fabrication of complex three-dimensional structures with sub-micron resolution in a single exposure/development cycle. We analyze the kinetics of two-photon polymerization in multi-functional acrylic photopolymers and SU-8 epoxy resins as a function of two-photon photosensitizer and electron acceptor concentrations. The rate of polymerization is observed to be directly proportional to the concentration of the two-photon photosensitizer, directly proportional to the square of the intensity, and varies more weakly with the concentration of electron acceptor. A transition from high aspect ratio to low aspect ratio structures is observed that depends on both the energy absorbed per unit area and the concentration of the photoinitiator system. In acrylates, quantitative estimates of the photoinitiation rates suggest that the concentration of radicals at threshold is much higher under two-photon exposure conditions than under one-photon exposure conditions. Diffusion of radicals or inhibitors into or out of the illuminated region may have important effects on the overall reaction rate for two-photon induced polymerization.
Energy Storage in Ultrathin Solid Oxide Fuel Cells (2012)

The power output of hydrogen fuel cells quickly decreases to zero if the fuel supply is interrupted. We demonstrate thin film solid oxide fuel cells with nanostructured vanadium oxide anodes that generate power for significantly longer time than reference porous platinum anode thin film solid oxide fuel cells when the fuel supply is interrupted. The charge storage mechanism was investigated quantitatively with likely identified contributions from the oxidation of the vanadium oxide anode, its hydrogen storage properties, and different oxygen concentration at the electrodes. Fuel cells capable of storing charge even for short periods of time could contribute to ultraminiaturization of power sources for mobile energy.
Effect of grain size and microporosity on the in vivo behaviour of β-tricalcium phosphate scaffolds (2014)

Defining the most adequate architecture of a bone substitute scaffold is a topic that has received much attention over the last 40 years. However, contradictory results exist on the effect of grain size and microporosity. Therefore, the aim of this study was to determine the effect of these two factors on the in vivo behaviour of β-tricalcium phosphate (β-TCP) scaffolds. For that purpose, β-TCP scaffolds were produced with roughly the same macropore size (≈ 150 μm), and porosity (≈ 80 %), but two levels of microporosity (low: 10 % / high: ≈ 25 %) and grain size (small: 1.3 μm /large: ≈ 3.3 μm). The sample architecture was characterised extensively using materialography, Hg porosimetry, micro-computed tomography (μCT), and nitrogen adsorption. The scaffolds were implanted for 2, 4 and 8 weeks in a cylindrical 5-wall cancellous bone defect in sheep. The histological, histomorphometrical and μCT analysis of the samples revealed that all four scaffold types were almost completely resorbed within 8 weeks and replaced by new bone. Despite the three-fold difference in microporosity and grain size, very few biological differences were observed. The only significant effect at p < 0.01 was a slightly faster resorption rate and soft tissue formation between 4 and 8 weeks of implantation when microporosity was increased. Past and present results suggest that the biological response of this particular defect is not very sensitive towards physico-chemical differences of resorbable bone graft substitutes. As bone formed not only in the macropores but also in the micropores, a closer study at the microscopic and localised effects is necessary.
Antioxidant activity of phytosterols, oryzanol, and other phytosterol conjugates (2002)

Abstract Antioxidant activity of phytosterols, oryzanol, ferulic acid ester of sterols, corn fiber oil, and rice bran oil was investigated. Commercial soybean oil and distilled soybean oil FAME were used as substrates for both oxidative stability determination and viscosity analysis after the oil was oxidized. At low concentration, these materials did not improve the oxidative stability of the oil substrates, although the viscosity tended to be reduced slightly. The antipolymerization activity of steryl ferulate was higher at higher concentration than at lower concentration, and steryl ferulate was more effective than oryzanol. Rice bran oil showed very good antioxidant and antipolymerization activities.
Acoustic Emission source location by a MEMS AE Sensor (2017)

Among the many types of sensors for measuring vibration, the AE sensor is designed to measure acoustic emission, i.e., small-amplitude vibration. Most AE sensors use piezoelectric material as transducers. Compared with the piezoelectric sensors, MEMS sensors have beneficial characteristics such as low cost attributable to mass production and smaller size. The SA sensor is a type of MEMS sensor and has broad frequency bandwidth. Exploiting this characteristic, the SA sensor can be used as a multifunctional vibration sensor to measure several frequency ranges conventionally measured by multiple sensors. In this paper, PLB test results measured by SA and AE sensors are evaluated by wavelet transform to investigate the applicability of the SA sensor for AE measurement.