gebhart/patrepeval huggingface dataset:
Pharmacodynamics and pharmacokinetics of DMP 728, a platelet GPIIb/IIIa antagonist, in healthy subjects (1998)

DMP 728 showed a dose-dependent inhibition of platelet aggregation at doses of 0.05 to 0.9 mg per subject, with a maximal inhibition (> 90%) of platelet aggregation at doses of 0.9 mg per subject and higher. Minimal changes in bleeding time from baseline were observed at doses up to 0.6 mg per subject. At the 0.9 mg/subject dose level, bleeding time was prolonged by approximately twofold to threefold above the baseline. At higher doses (1.5 mg/subject to 3.9 mg/subject), bleeding time prolongation was > 30 minutes during the infusion. In all dose groups, bleeding times returned to the control value within 8 hours after cessation of the infusion. Maximum plasma concentration and area under the curve of DMP 728 increased linearly and proportionally to the dose. No clinical changes in vital signs, 12-lead electrocardiograms, physical examinations, coagulation tests, or stool hemoccult tests were observed at any of the doses. In conclusion, DMP 728 is a potent antiplatelet agent and well tolerated at doses ranging from 0.05 to 3.0 mg/subject.
Indexing and Search of Correlated Business Events (2007)

Complex event processing (CEP) is an emerging technology gaining a lot of momentum in research as well as in commercial products. CEP is a technique that utilizes event-driven IT-systems to monitor, optimize and steer todays business situations in real-time. Lots of contributions have been published on how to handle large amounts of event streams and how to extract meaningful knowledge out of often fine-grained events. From our experience we learned that complex use cases implemented with CEP need appropriate tool support to validate, understand and analyze the event processing done by the CEP software. We introduce the EventCloud system which is a generic event search and analysis tool integrating with CEP solutions in almost every domain. EventCloud is an end user application that allows complex search and analysis of correlated events. As CEP requires a highly specialized system architecture, the characteristics of events also have impacts on the infrastructure for indexing, searching and analyzing events. In this paper we present two approaches describing how to properly represent correlated events in persistent storages to allow performant event indexing and searching. Further we describe the "document-oriented" approach, where correlated events are managed in a full-text index and discuss the problems and pitfalls with its implementation in Apache Lucene. Finally we compare different full-text engines, namely Apache Lucene and Microsoft SQL Server 2005, to analyze their performance and features for event indexing and search
Optimization of illuminating system to detect optical properties inside a finger (2007)

Biometrics performs personal authentication using individual bodily features including fingerprints, faces, etc. These
technologies have been studied and developed for many years. In particular, fingerprint authentication has evolved over many years, and fingerprinting is currently one of world's most established biometric authentication techniques.
Not long ago this technique was only used for personal identification in criminal investigations and high-security
facilities. In recent years, however, various biometric authentication techniques have appeared in everyday applications.
Even though providing great convenience, they have also produced a number of technical issues concerning operation.
Generally, fingerprint authentication is comprised of a number of component technologies: (1) sensing technology for
detecting the fingerprint pattern; (2) image processing technology for converting the captured pattern into feature data
that can be used for verification; (3) verification technology for comparing the feature data with a reference and
determining whether it matches. Current fingerprint authentication issues, revealed in research results, originate with
fingerprint sensing technology. Sensing methods for detecting a person's fingerprint pattern for image processing are
particularly important because they impact overall fingerprint authentication performance. The following are the current
problems concerning sensing methods that occur in some cases: Some fingers whose fingerprints used to be difficult to
detect by conventional sensors. Fingerprint patterns are easily affected by the finger's surface condition, such noise as
discontinuities and thin spots can appear in fingerprint patterns obtained from wrinkled finger, sweaty finger, and so on.
To address these problems, we proposed a novel fingerprint sensor based on new scientific knowledge. A
characteristic of this new method is that obtained fingerprint patterns are not easily affected by the finger's surface
condition because it detects the fingerprint pattern inside the finger using transmitted light.
We examined optimization of illumination system of this novel fingerprint sensor to detect contrasty fingerprint pattern
from wide area and to improve image processing at (2).
Biochemical and hematologic effects of polyvinylpyrrolidone-wrapped fullerene C60 after oral administration. (2013)

The fullerene C60 is used in consumer products such as cosmetics owing to its antioxidative effects and is being developed for nanomedical applications. However, knowledge regarding the safety of fullerene C60, especially after oral administration, is sparse. Here, we examined the safety of fullerene C60 in mice after 7 d of exposure to orally administered polyvinylpyrrolidone (PVP)-wrapped fullerene C60 (PVP-fullerene C60). Mice treated with PVP-fullerene C60 showed few changes in the plasma levels of various markers of kidney and liver injury and experienced no significant hematologic effects. Furthermore, the histology of the colon of PVP-fullerene C60-treated mice was indistinguishable from that of control mice. These results suggest that PVP-fullerene C60 lacks toxicity after high-dose oral administration and indicate that PVP-fullerene C60 can be considered safe for oral medication. These data provide basic information that likely will facilitate the production of safe and effective forms of fullerene C60.
Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma (2020)

Our results demonstrate that intratumorally administered MS not only target the TME, but also drain to the TDLN. Furthermore, MS encapsulated with a potent antitumor cytokine, IL-12, induce an antitumor cytokine profile in the TDLN, which is essential for treatment efficacy.
PSMA Ligands for PET Imaging of Prostate Cancer (2017)

Targeting the prostate-specific membrane antigen (PSMA) with <sup>68</sup>Ga-labeled and <sup>18</sup>F-labeled PET agents has become increasingly important in recent years. Imaging of biochemically recurrent prostate cancer has been established as a widely accepted clinical indication for PSMA ligand PET/CT in many parts of the world because of the results of multiple, primarily retrospective, studies that indicate superior detection efficacy compared with standard-of-care imaging. For high-risk primary prostate cancer, evidence is growing that this modality significantly aids in the detection of otherwise occult nodal and bone metastases. For both clinical indications in recurrent as well as in primary prostate cancer, preliminary data demonstrate a substantial impact on clinical management. Emerging data imply that intraprostatic tumor localization, therapy stratification, and treatment monitoring of advanced disease in specific clinical situations might become future indications. Current criteria for image reporting of PSMA ligand PET are evolving given the expanding body of literature on physiologic and pathologic uptake patterns and pitfalls. This article intends to give an educational overview on the current status of PSMA ligand PET imaging, including imaging procedure and interpretation, clinical indications, diagnostic potential, and impact on treatment planning.
Issues on Risk Analysis for Critical Infrastructure Protection (2020)

Critical infrastructure provides essential services to citizens. The mutual dependencies of services between systems form a complex “system of systems” with a large perturbation surface, prone to be damaged by natural and anthropic events. Their intrinsic and extrinsic vulnerabilities could be overcome by providing them adaptive properties to allow fast and effective recovery from loss of functionality. Resilience is thus the key issue, and its enhancement, at the systemic level, is a priority goal to be achieved. This volume reviews recent insights into the different domains (resilience-enhancing strategies, impact and threats knowledge, and dependency-related issues) and proposes new strategies for better critical infrastructure protection.
Band gap bowing for high In content InAlN films (2019)

The InAlN alloy system has bandgap energies that span the entire visible range and is a promising candidate for bandgap engineering. To facilitate bandgap engineering, the bandgap bowing for the entire composition range must be well characterized. In rich InxAl1−xN (x &amp;gt; 0.60), films were grown via plasma assisted molecular beam epitaxy on freestanding GaN substrates. The InxAl1−xN film compositions were determined using high resolution X-ray diffraction. On-axis 0002 ω-2θ scans were used to determine the c spacing of the films, reciprocal space maps of the 1¯015 peaks were used to determine that the films were completely relaxed, and the film compositions were calculated from that information assuming Vegard's law. The bandgaps were independently measured using absorbance spectroscopy and fitting to the linear region of a Tauc plot (dependence of α2 hν on hν) as determined by interpolating the second derivative of the data and selecting a region of low curvature. Compared with the literature, the data were fit to a composition-independent bandgap bowing model, and a bowing parameter of b = 4.0 ± 0.2 eV was calculated, which is consistent with previous results.
Design and Analysis of a Variable-Speed Constant-Amplitude Wind Generator for Stand-Alone DC Power Applications (2023)

This article presents the design and analysis of a permanent magnet (PM) wind generator, which consists of two sets of windings, and two rotors. The proposed PM wind generator is designed for variable-speed constant-amplitude voltage operation in dc power applications, in order to maximize the utilization of wind energy and make the electricity more accessible to stand-alone situations, e.g., remote areas and offshore islands. The operating principle of the variable-speed constant-amplitude voltage operation of the proposed PM wind generator is demonstrated in detail. A comparative study is carried out among the proposed generator, a conventional surface-mounted PM synchronous generator, and an existing counterpart generator used for the same application. The results show that compared to the conventional PM synchronous generator and the existing counterpart, the proposed PM wind generator exhibits the advantages of high induced voltage, high torque/power density, high efficiency, etc. Finally, the proposed PM wind generator is prototyped and manufactured. The validity of the variable-speed constant-amplitude operation of the proposed generator under both steady-state and dynamic conditions, is verified by experimental results.
Supplementary Figure 1C from Molecular Triage of Premalignant Lesions in Liquid-Based Cervical Cytology and Circulating Cell-Free DNA from Urine, Using a Panel of Methylated Human Papilloma Virus and Host Genes (2023)

&lt;p&gt;Phase 2 Biomarker Development Trial was performed to develop a clinical assay based on a specimen that can be obtained noninvasively. Promoter methylation of FKBP6, ZNF516 and INTS1 was quantified with qMSP in samples from three cohorts of women who underwent biopsy after colposcopy and were diagnosed with no intraepithelial lesions or malignancy (NILM) or Cervical Intraepithelial Neoplasia (CIN) grades 1-3. The first was a retrospective cohort of cervical brush samples (n=214) obtained from women in Chile who had a biopsy diagnosed with NILM (n=37), CIN1 (n=34), CIN2 (n=33), CIN3 (n=20), and squamous cell carcinoma (n=90). The second was a prospective cohort of liquid-based cytology samples (n=67) collected from women in Puerto Rico, which was used to confirm with qMSP the results previoulsy obtained in this experiment. The third was another prospective cohort (n=40) of samples collected from women in Puerto Rico who provided paired liquid-based cytology, plasma and urine samples. hrHPV status for cervical brush and liquid biopsy samples in each cohort was confirmed with a PCR based assay that quantifies E6 and E7 in genomic DNA. qMSP primers and probes for HPV16L1 gene were also used to test the cohorts from Puerto Rico.&lt;/p&gt;
Button battery ingestion complications (2017)

Corrosive injuries of the upper gastrointestinal tract due to button batteries often require a multidisciplinary approach due to the potential for multiple complications. We present two cases of button battery ingestion in toddlers; one patient developed a corrosive tracheoesophageal fistula and the other a localized perforation.
A live video analytic system for affect analysis in public space (2015)

We propose a video analytic system capable of analyzing group density and social signals such as affect in public space. In contrast to most facial analysis systems that operate on fixed cameras, this demonstration incorporates Pan-Tilt-Zoom (PTZ) camera control and facial video analysis hand in hand, in order to effectively locate individuals, distill expression signals and provide visual feedback in realtime. We assume individuals can sit on a fixed number of seats or benches. Our PTZ control module operates cooperatively with a face analysis module to actively search for facial shots in the public space and perform expression and pose analysis. Group density is estimated as the occupancy rate with respect to the possible seating locations and group-level affect is inferred from aggregate facial expression recognition.
Cyclosporine attenuates the autonomic modulation of reflex chronotropic responses in conscious rats (2002)

Cyclosporine A (CyA), an immunosuppressant drug, has been shown to attenuate the baroreflex control of heart rate (HR). This study investigated whether or not the CyA-induced baroreflex dysfunction is due to alterations in the autonomic (sympathetic and parasympathetic) control of the heart. We evaluated the effect of muscarinic or beta-adrenergic blockade by atropine and propranolol, respectively, on reflex HR responses in conscious rats treated with CyA (20 mg x kg(-1) x day(-1) dissolved in sesame oil) for 11-13 days or the vehicle. Baroreflex curves relating changes in HR to increases or decreases in blood pressure (BP) evoked by phenylephrine (PE) and sodium nitroprusside (NP), respectively, were constructed and the slopes of the curves were taken as a measure of baroreflex sensitivity (BRS(PE) and BRS(NP)). Intravenous administration of PE and NP produced dose-related increases and decreases in BP, respectively, that were associated with reciprocal changes in HR. CyA caused significant (P < 0.05) reductions in reflex HR responses as indicated by the smaller BRS(PE) (-0.97 +/- 0.07 versus -1.47 +/- 0.10 beats x min(-1) x mmHg(-1) (1 mmHg = 133.322 Pa)) and BRS(NP) (-2.49 +/- 0.29 versus -5.23 +/- 0.42 beats x min(-1) x mmHg(-1)) in CyA-treated versus control rats. Vagal withdrawal evoked by muscarinic blockade elicited significantly lesser attenuation of BRS(PE) in CyA compared with control rats (40.2 +/- 8.0 versus 57.7 +/- 4.4%) and abolished the BRS(PE) difference between the two groups, suggesting that CyA reduces vagal activity. CyA also appears to impair cardiac sympathetic control because blockade of beta-adrenergic receptors by propranolol was less effective in reducing reflex tachycardic responses in CyA compared with control rats (41.6 +/- 4.2 versus 59.5 +/- 4.5%). These findings confirm earlier reports that CyA attenuates the baroreceptor control of HR. More importantly, the study provides the first pharmacological evidence that CyA attenuates reflex chronotropic responses via impairment of the autonomic modulation of the baroreceptor neural pathways.
How to access treatment technology information (1995)

In this information age, there is a wealth of data on innovative treatment technologies being created at a very fast pace. The exchange of new information via telecommunication is prompt and far-reaching. For environmental protection and health and risk-related issues, there are quite a number of databases developed by US EPA currently available, both as on-line search systems and as discrete diskette-based databases. However, when it comes to the issues and problems of treatment and remediation of hazardous wastes, EPA`s ATTIC (Alternative Treatment Technology Information Center) database (DB) was developed to provide convenient one-stop shopping for the most recent information on alternative methods to treat hazardous wastes. Whether your issue is pollution prevention, waste treatment, clean-up operations, decontamination or one of a number of treatment technologies (thermal, solidification and stabilization, physical, chemical or biological remediation), ATTIC can offer you relevant information. Access to this information is free of charge and available 24 hours a day, seven days a week. You can use your personal computer (PC) to conduct an on-line search of ATTIC. The desired information then can be flagged for downloading from the centralized ATTIC computer to your own PC.
Data center TCO benefits of reduced system airflow (2008)

New blade chassis designs, with banks of aggregate fans and system-level thermal architectures which precisely manage airflow, have enabled a new level of energy savings for enterprise customers that extends beyond the system and offers an opportunity for new system thermal design principles. By reducing system airflow rate to an absolute minimum, system fan power is minimized. More significantly, lowering airflow rates reduces data center cooling infrastructure power requirements. This work outlines the opportunities enabled by extending this concept to all IT equipment design and coupling the concept with data centers control mechanisms, tying server inlet temperatures to air conditioning flow rates and set point temperatures, for breakthrough infrastructure cost structures.
Bio-Inspired Enterprise Security (2011)

Providing security for enterprises is difficult due to the size and complexity of their computing and networking infrastructures. These environments consist of a large number of diverse systems and services that continually change, thus they are difficult to defend using current static-oriented defense mechanisms. This paper introduces a new security paradigm that mimics designs in nature to ensure the safety and soundness of infrastructures that are potentially very diverse and dynamic. Primary inspiration has come from ant colonies, social networking, and bioinformatics. The proposed framework combines these ideas to provide complex-adaptive security for computer systems, telecommunications, and critical Supervisory Control and Data Acquisition (SCADA) infrastructures.
NMR-Based Quantification of β-Sheet Populations in Aqueous Solution through Use of Reference Peptides for the Folded and Unfolded States (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTNMR-Based Quantification of β-Sheet Populations in Aqueous Solution through Use of Reference Peptides for the Folded and Unfolded StatesFaisal A. Syud, Juan F. Espinosa, and Samuel H. GellmanView Author Information Department of Chemistry, University of Wisconsin Madison, Wisconsin 53706 Cite this: J. Am. Chem. Soc. 1999, 121, 49, 11577–11578Publication Date (Web):November 30, 1999Publication History Received2 August 1999Revised19 October 1999Published online30 November 1999Published inissue 1 December 1999https://pubs.acs.org/doi/10.1021/ja992733thttps://doi.org/10.1021/ja992733trapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views829Altmetric-Citations108LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Conformation,Cyclization,Monomers,Peptides and proteins,Solution chemistry Get e-Alerts
Ultrafast Wiggling and Jiggling: Ir2(1,8-diisocyanomenthane)42+ (2017)

Binuclear complexes of d<sup>8</sup> metals (Pt<sup>II</sup>, Ir<sup>I</sup>, Rh<sup>I</sup>,) exhibit diverse photonic behavior, including dual emission from relatively long-lived singlet and triplet excited states, as well as photochemical energy, electron, and atom transfer. Time-resolved optical spectroscopic and X-ray studies have revealed the behavior of the dimetallic core, confirming that M-M bonding is strengthened upon dσ* → pσ excitation. We report the bridging ligand dynamics of Ir<sub>2</sub>(1,8-diisocyanomenthane)<sub>4</sub><sup>2+</sup> (Ir(dimen)), investigated by fs-ns time-resolved IR spectroscopy (TRIR) in the region of C≡N stretching vibrations, ν(C≡N), 2000-2300 cm<sup>-1</sup>. The ν(C≡N) IR band of the singlet and triplet dσ*pσ excited states is shifted by -22 and -16 cm<sup>-1</sup> relative to the ground state due to delocalization of the pσ LUMO over the bridging ligands. Ultrafast relaxation dynamics of the <sup>1</sup>dσ*pσ state depend on the initially excited Franck-Condon molecular geometry, whereby the same relaxed singlet excited state is populated by two different pathways depending on the starting point at the excited-state potential energy surface. Exciting the long/eclipsed isomer triggers two-stage structural relaxation: 0.5 ps large-scale Ir-Ir contraction and 5 ps Ir-Ir contraction/intramolecular rotation. Exciting the short/twisted isomer induces a ∼5 ps bond shortening combined with vibrational cooling. Intersystem crossing (70 ps) follows, populating a <sup>3</sup>dσ*pσ state that lives for hundreds of nanoseconds. During the first 2 ps, the ν(C≡N) IR bandwidth oscillates with the frequency of the ν(Ir-Ir) wave packet, ca. 80 cm<sup>-1</sup>, indicating that the dephasing time of the high-frequency (16 fs)<sup>-1</sup> C≡N stretch responds to much slower (∼400 fs)<sup>-1</sup> Ir-Ir coherent oscillations. We conclude that the bonding and dynamics of bridging di-isocyanide ligands are coupled to the dynamics of the metal-metal unit and that the coherent Ir-Ir motion induced by ultrafast excitation drives vibrational dephasing processes over the entire binuclear cation.