gebhart/patrepeval huggingface dataset:
Abstract 5341: Derangements in HUWE1/c-MYC pathway confer sensitivity to the BET bromodomain inhibitor GS-626510 in uterine cervical carcinoma (2020)

Abstract Purpose: The prognosis for women with advanced or recurrent cervical cancer (CC) no longer responsive to radiation and/or chemotherapy remains poor. Whole-exome-sequencing (WES) studies have recently reported c-MYC gene amplification and HUWE1 gene mutations in a significant number of CC suggesting the HUWE1/c-MYC pathway as potential therapeutic target. We investigated HUWE1 and c-MYC expression in fresh-frozen CC and the potential activity of the novel BET bromodomain inhibitor GS-626510 (Gilead-Science-Inc.) against primary WES CC-cultures and CC-xenografts. Experimental Design: HUWE1 and c-MYC expression were evaluated by qRT-PCR in a total of 23 CC including 12 fresh frozen tumor tissues and 11 primary cell lines. c-MYC expression was also evaluated by Western-Blot (WB) and fluorescence in situ hybridization (FISH) experiments in all 11 fully sequenced primary CC cell lines. Primary tumors were evaluated for sensitivity to GS-626510 in-vitro using proliferation and viability-assays. siRNA experiments were used to evaluate the effect of HUWE1 silencing on primary CC cell line growth and sensitivity to GS-626510. Finally, the in-vivo activity of GS-626510 was studied in CC-CVX8 mouse-xenografts. Results: Fresh-frozen CC and primary CC cell lines overexpressed c-MYC when compared to normal control tissues (mean ± SEM mRNA values = 7.06 ± 1.17 vs a mean ± SEM = 2.96 ± 0.97, p = 0.01). FISH experiments demonstrated amplification of c-MYC in 9 out of 11 (82%) of the primary CC cell lines. Primary CC cell lines with derangements in the HUWE1/c-MYC pathway were highly sensitive to GS-626510, with a dose-response decrease in cell proliferation and IC50 values ranging from 3 to 57 nM. Silencing of HUWE1 by siRNA significantly increased c-MYC expression as well as CC cell proliferation and enhanced the in vitro sensitivity to GS-626510. Twice daily oral doses of GS-626510 (10 mg/kg) were well tolerated in vivo in animals and highly effective in decreasing tumor-growth (p = 0.004) and increasing survival (p value = 0.004) of mice harboring CC-CVX8 xenografts. Conclusions: Downregulation/inactivation of HUWE1 may increase c-MYC expression and proliferation in primary CC cell lines. GS-626510 may represent a novel, potentially highly effective therapeutic agent against CC overexpressing c-MYC and/or harboring HUWE1 mutations. Clinical studies with BET inhibitor in CC-patients harboring radiation/chemotherapy-resistant disease are warranted. Citation Format: Elena Bonazzoli, Stefania Bellone, Luca Zammataro, Barbara Gnutti, Adele Guglielmi, Silvia Pelligra, Paola Manara, Joan Tymon-Rosario, Burak Zeybek, Chanhee Han, Alessandro D. Santin. Derangements in HUWE1/c-MYC pathway confer sensitivity to the BET bromodomain inhibitor GS-626510 in uterine cervical carcinoma [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 5341.
Economic Dispatch-Based Secondary Control for Islanded Microgrid (2022)

In microgrids, the economic dispatch is usually considered in the tertiary control level where the control time constant takes several minutes. Therefore, the loads and renewable energy production is required to be estimated. The estimationbased methods introduce uncertainty to the optimization function that degrades the optimal solution. In this paper, the economic dispatch is integrated with the secondary control in such a way that it provides its functionalities and economic dispatch. An optimization function for secondary control is utilized to minimize the cost of active power generation subjected to frequency and voltage nominal and power rating values. The optimization function is solved in real time on a timescale of 0.5 sec. The proposed controller is simulated using MATLAB/SIMULINK and compared with decentralized secondary controller with the objective to restore the frequency and voltage of the microgrid. The proposed controller effectively reduces the cost by 7% as compared to decentralized controller.
Thyrotoxic adenoma followed by atypical hyperthyroidism due to struma ovarii: clinical and genetic studies (2004)

This is the first well-documented report of thyrotoxic struma ovarii revealed after treatment of a single thyroid toxic adenoma. We have shown in this case that struma ovarii originates from a single germ cell, and, albeit benign, this tumor presents several chromosomal abnormalities. Struma ovarii-induced hyperthyroidism is likely to be mediated by mechanisms different from those of the classical thyroid toxic adenoma.
Variable Temperature Mobility Analysis of n‐Channel, p‐Channel, and Ambipolar Organic Field‐Effect Transistors (2009)

Abstract The temperature dependence of field‐effect transistor (FET) mobility is analyzed for a series of n‐channel, p‐channel, and ambipolar organic semiconductor‐based FETs selected for varied semiconductor structural and device characteristics. The materials (and dominant carrier type) studied are 5,5′′′‐bis(perfluorophenacyl)‐2,2′:5′,2″:5″,2′′′‐quaterthiophene ( 1 , n‐channel), 5,5′′′‐bis(perfluorohexyl carbonyl)‐2,2′:5′,2″:5″,2′′′‐quaterthiophene ( 2 , n‐channel), pentacene ( 3 , p‐channel); 5,5′′′‐bis(hexylcarbonyl)‐2,2′:5′,2″:5″,2′′′‐quaterthiophene ( 4 , ambipolar), 5,5′′′‐bis‐(phenacyl)‐2,2′: 5′,2″:5″,2′′′‐quaterthiophene ( 5 , p‐channel), 2,7‐bis((5‐perfluorophenacyl)thiophen‐2‐yl)‐9,10‐phenanthrenequinone ( 6 , n‐channel), and poly( N ‐(2‐octyldodecyl)‐2,2′‐bithiophene‐3,3′‐dicarboximide) ( 7 , n‐channel). Fits of the effective field‐effect mobility ( µ eff ) data assuming a discrete trap energy within a multiple trapping and release (MTR) model reveal low activation energies ( E A s) for high‐mobility semiconductors 1 – 3 of 21, 22, and 30 meV, respectively. Higher E A values of 40–70 meV are exhibited by 4 – 7 ‐derived FETs having lower mobilities ( µ eff ). Analysis of these data reveals little correlation between the conduction state energy level and E A , while there is an inverse relationship between E A and µ eff . The first variable‐temperature study of an ambipolar organic FET reveals that although n‐channel behavior exhibits E A = 27 meV, the p‐channel regime exhibits significantly more trapping with E A = 250 meV. Interestingly, calculated free carrier mobilities ( µ 0 ) are in the range of ∼0.2–0.8 cm 2 V −1 s −1 in this materials set, largely independent of µ eff . This indicates that in the absence of charge traps, the inherent magnitude of carrier mobility is comparable for each of these materials. Finally, the effect of temperature on threshold voltage ( V T ) reveals two distinct trapping regimes, with the change in trapped charge exhibiting a striking correlation with room temperature µ eff . The observation that E A is independent of conduction state energy, and that changes in trapped charge with temperature correlate with room temperature µ eff , support the applicability of trap‐limited mobility models such as a MTR mechanism to this materials set.
High-Power ($> 110$ mW) Superluminescent Diodes by Using Active Multimode Interferometer (2010)

We have designed and fabricated, for the first time to our knowledge, novel superluminescent diodes by using active multimode interferometers that emit at a wavelength of 1.55 ¿ m. An output power as high as 115 mW was obtained with a wide 3-dB bandwidth of 50 nm and low spectral ripple of 0.03 dB. In addition, they showed stable single-transverse-mode outputs up to the maximum output power.
Effects of Variation of Composition and Block Sequence on Properties of Copolymers Containing Semicrystalline Block(s) (1982)

The effect of variations in molecular architecture and composition on bulk properties is reported for a series of well characterized hydrogenated block copolymers of butadiene (HB) and isoprene (HI), each with a total molecular weight of ~200,000 and a narrow distribution (Mw/Mn < 1.1). The polymers were synthesized by sequential anionic polymerization followed by hydrogenation, using p-toluenesulfonylhydrazide. The material properties of the homopolymeric HI and HB were also investigated. As expected, HI is rubbery at room temperature and HB is a tough semicrystalline plastic with properties simlar to those of a low density polyethylene (LDPE). The crystallinity, density and ΔHf for all of the block copolymers were found to be linearly dependent on HB content indicating that little mixing exists between the HB and HI blocks in the solid state. Although the solution cast films of the block copolymers were spherulitic, the quenched films displayed no distinct structure on the
Woman and Art in Early Modern Latin America (2006)

Acknowledgments, List of Illustrations Introduction, Kellen Kee McIntyre Part I. RECONNAISSANCE: MARKING AND MAPPING THE NEW WORLD WITH THE FEMALE BODY Chapter One. The Queen of Heaven Reigns in New Spain: The Triumph of Eternity in the Casa del Dean Murals, Penny C. Morrill Chapter Two. Affections of the Heart: Female Imagery and the Notion of Nation in Nineteenth-Century Mexico, Magali M. Carrera Chapter Three. The Virgin of the Andes: Inka Queen and Christian Goddess, Carol Damian Chapter Four. Women and Men as Cosmic Co-Bearers at Oaxtepec, Mexico, about 1553, Richard E. Phillips Part II. TAKING POSSESSION: APPROPRIATIONS OF THE NEW WORLD/FEMALE BODY Chapter Five. Abused and Battered: Printed Images and the Female Body in Viceregal New Spain, K. Donahue-Wallace Chapter Six. Reclaiming Tlatilco's Figurines from Biased Analysis, Maria Elena Bernal-Garcia Chapter Seven. El encuentro de Cortes y Moctezuma: The Betrothal of Two Worlds in Eighteenth-Century New Spain, Ray Hernandez-Duran Chapter Eight. Nurture and Inconformity: Arrieta's Images of Women, Food, and Beverage, Jenny O. Ramirez Part III. CONSOLIDATION: THE QUALIFYING AND TAMING OF THE NEW WORLD/FEMALE BODY WITH SIGNIFIEDS Chapter Nine. Clothing Women: The Female Body in Pre- and Post-Contact Aztec Art, Lori Boornazian Diel Chapter Ten. Savage Breast/Salvaged Breast: Allegory, Colonization, and Wet-Nursing in Peru, 1532-1825, Carolyn Dean Chapter Eleven. Emblems of Virtue in Eighteenth-Century New Spain, Michael J. Schreffler Chapter Twelve. The Figure of Mary as the Cloister in Mexican Mendicant Art, Richard E. Phillips Part IV. FULFILLMENT: THE EXTENSION AND EXPRESSION OF THE FEMALE BODY IN THE NEW WORLD Chapter Thirteen. Convents, Art, and Creole Identity in Late Viceregal New Spain, Elizabeth Perry Chapter Fourteen. The Sweeping of the Way: Rethinking the Mexican Ochpaniztli Festival, Catherine R. DiCesare Chapter Fifteen. Exploring a Female Legacy: Beatriz Alvarez de Herrera and the Facade of the Casa de Montejo, C. Cody Barteet Chapter Sixteen. Isabel de Cisneros in Her Own Role, A. Lepage Chapter Seventeen. From Mujercilla to Conquistadora: St. Teresa of Avila's Missionary Identity in Mexican Colonial Art, Christopher C. Wilson Index
Optimal DoF Region of the $K$ -User MISO BC With Partial CSIT (2017)

We consider the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$K$ </tex-math></inline-formula> -user multiple-input-single-output broadcast channel, where the transmitter, equipped with <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$M$ </tex-math></inline-formula> antennas, serves <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$K$ </tex-math></inline-formula> users, with <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$K \leq M$ </tex-math></inline-formula> . The transmitter has access to a partial channel state information of the users. This is modeled by letting the variance of the channel state information at the transmitter error of user <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$i$ </tex-math></inline-formula> scale as <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$O(P^{-\alpha _{i}}$ </tex-math></inline-formula> ) for the signal-to-noise ratio <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$P$ </tex-math></inline-formula> and some constant <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\alpha _{i} \geq 0$ </tex-math></inline-formula> . In this letter, we derive the optimal degrees-of-freedom region in such setting, and we show that rate-splitting is the key scheme to achieve such a region.
The episodic resurgence of highly pathogenic avian influenza H5 virus (2023)

Abstract Highly pathogenic avian influenza (HPAI) H5N1 activity has intensified globally since 2021, replacing the dominant clade 2.3.4.4 H5N8 virus. H5N1 viruses have spread rapidly to four continents, causing increasing reports of mass mortality in wild birds and poultry. The ecological and virological properties required for future mitigation strategies are unclear. Using epidemiological, spatial and genomic approaches, we demonstrate changes in the source of resurgent H5 HPAI and reveal significant shifts in virus ecology and evolution. Outbreak data indicates key resurgent events in 2016/17 and 2020/21 that contributed to the panzootic spread of H5N1 in 2021/22, including an increase in virus diffusion velocity and persistence in wild birds. Genomic analysis reveals that the 2016/17 epizootics originated in Asia, where HPAI H5 reservoirs are documented as persistent. However, in 2020/21, 2.3.4.4b H5N8 viruses emerged in domestic poultry in Africa, featuring several novel mutations altering the HA structure, receptor binding, and antigenicity. The new H5N1 virus emerged from H5N8 through reassortment in wild birds along the Adriatic flyway around the Mediterranean Sea. It was characterized by extensive reassortment with low pathogenic avian influenza in domestic and wild birds as it spread globally. In contrast, earlier outbreaks of H5N8 were caused by a more stable genetic constellation, highlighting dynamic changes in HPAI H5 genomic evolution. These results suggest a shift in the epicenter of HPAI H5 beyond Asia to new regions in Africa, the Middle East, Europe, and North and South America. The persistence of HPAI H5 with resurgence potential in domestic birds indicates that elimination strategies remain a high priority.
High spatiotemporal resolution of river planform dynamics from Landsat: The RivMAP toolbox and results from the Ucayali River (2016)

Abstract Quantifying planform changes of large and actively migrating rivers such as those in the tropical Amazon at multidecadal time scales, over large spatial domains, and with high spatiotemporal frequency is essential for advancing river morphodynamic theory, identifying controls on migration, and understanding the roles of climate and human influences on planform adjustments. This paper addresses the challenges of quantifying river planform changes from annual channel masks derived from Landsat imagery and introduces a set of efficient methods to map and measure changes in channel widths, the locations and rates of migration, accretion and erosion, and the space‐time characteristics of cutoff dynamics. The techniques are assembled in a comprehensive MATLAB toolbox called RivMAP (River Morphodynamics from Analysis of Planforms), which is applied to over 1500 km of the actively migrating and predominately meandering Ucayali River in Peru from 1985 to 2015. We find multiscale spatial and temporal variability around multidecadal trends in migration rates, erosion and accretion, and channel widths revealing a river dynamically adjusting to sediment and water fluxes. Confounding factors controlling planform morphodynamics including local inputs of sediment, cutoffs, and climate are parsed through the high temporal analysis.
Persistent Channel Power Deviations in Constant Gain Amplified Long-Chain ROADM Networks (2011)

Numerical simulations of the evolution of the channel power response to power adjustments in constant gain amplified degree-2 ROADM networks demonstrate novel persistent and periodic distant-dependent power deviation patterns.
Peptidomimetics for Bridging Structure and Function: Pseudo-Prolines (?Pro) in Peptide Synthesis, Molecular Recognition, and Drug Design (2001)

The central issue of bioorganic chemistry is to unravel the structural and functional complexity of living systems by designing synthetic models that mimic essential features of biomolecules. In view of the expected exponential growth of knowledge within the next decade about structure–activity relationships in bioactive compounds as well as about mechanisms of molecular recognition in cellular communication, conversion of the design of therapeutically relevant molecules currently provides one of the most fascinating challenges for synthetic organic chemistry. Independent of evolutionary restrictions in creating the molecules of life, the chemist may even go a step further in extending Nature's pool of biomolecules for studying biochemical processes. One way of doing this is illustrated in the present article. Taking proline (Pro) as a unique building block in peptides and proteins, we have explored its particular role in a variety of biological processes by tuning its intrinsic structural and functional properties using readily accessible proline mimetics ('pseudoprolines', ?Pro). In enhancing and extending well-known Pro effects, i.e. cis-trans amide bond isomerization, conformational restriction or specific receptor interaction, ?Pro derivatives are useful as synthetic tools in molecular recognition studies and for modulating the physicochemical, pharmacokinetic and biological properties of peptide and protein ligands. Selected examples from our ongoing research program in peptidomimetic chemistry demonstrate that synthetic tools can substantially contribute to our understanding of fundamental principles underlying biological processes and serve as a first step in accessing molecules of therapeutic relevance.
Development of broad spectral bandwidth hybrid QW/QD structures from 1000-1400 nm (2014)

We describe the development of hybrid quantum well (QW)/quantum dot (QD) active elements to achieve broad spectral bandwidth spontaneous emission and gain. We have previously reported that the placement of the QW within the active element is a critical factor in obtaining broad spectral bandwidth emission. We now present new designs to further broaden the spontaneous emission from hybrid structures by increasing the number of QD layers and dot density, and by using QDs with wider state-separation. Introducing chirped QD layers reduced the modulation in the spontaneous emission spectra, and by utilising self-heating effects and state-filling, a spontaneous emission with 3dB line-width of 350nm is obtained.
Directional lasing at high oblique angle from metasurface exhibiting multivalley dispersion (2018)

We report on a metasurface laser emitting at the valley extremum of a multivalley energy-momentum dispersion. Such peculiar dispersion shape is obtained by hybridizing high quality factor photonic modes of different symmetry and opposite effective mass. The lasing effect takes place at high oblique angle ($\sim$20 degrees), in the telecom wavelength range ($\sim$1580 nm), on silicon substrate and operating at room temperature. Our results show the potential of multivalley dispersion for micro-laser in integrated photonic and beam-steering applications. It also opens the way to study various features of valleytronic physics such as spontaneous momentum symmetry breaking, two-mode squeezing and Josephson oscillation in momentum space.
Excitation d'une Unique Onde de Fuite dans une Antenne Fabry- Perot Permettant la Génération de Polarisation Circulaire sur une Large Bande (2019)

International audience
Detection of Actinobacillus pleuropneumoniae in the porcine upper respiratory tract as a complement to serological tests. (1993)

Attempts were made to isolate Actinobacillus pleuropneumoniae from the nasal cavities and tonsils of 442 healthy pigs from 15 herds. Samples were streaked onto different media formulations. Serum samples were assayed for antibodies to A. pleuropneumoniae by enzyme-linked immunosorbent assay and complement fixation test. Actinobacillus pleuropneumoniae was isolated from the nasal cavities only in 24 pigs, from tonsils only in 90 pigs, and from both the nasal cavities and the tonsils in 11 pigs. A PPLO medium supplemented with lincomycin, bacitracin and crystal violet allowed recovery of A. pleuropneumoniae from more animals than a tryptic soy agar medium from both sites. Incubation of plates in an enriched CO2 atmosphere did not affect the recovery rate. Actinobacillus pleuropneumoniae belonging to serotypes 1, 2, 3, 5a, 5b, 7, 8, 10 and 12 were isolated, and, in several herds, more than one serotype were recovered. Serotypes of A. pleuropneumoniae were isolated from nine herds which were found seronegative to these. The isolation of A. pleuropneumoniae from the upper respiratory tract can be useful for detection of carrier pigs and complements serological screening.
69‐4: NBIS‐Stable Oxide Thin‐Film Transistors Using Ultra‐Wide Bandgap Amorphous Oxide Semiconductors (2016)

Ultra‐wide bandgap amorphous oxide semiconductors (UWB‐AOSs) were newly developed to improve photo‐stability of conventional AOS TFTs. The UWB‐AOSs have much larger bandgaps (∼3.8 eV) than conventional AOSs. Photo‐stable TFTs using a UWB‐AOS were fabricated at 200°C, which exhibited high saturation mobilities (∼7 cm 2 /Vs), high on/off ratios (&gt;10 8 ) and small S values (0.3 V/dec). The UWB‐AOS TFT showed no threshold voltage shift against NBIS test under white LED illumination (11,000 lux). This strong photo‐stability would enable completely transparent applications such as window displays.
A Survey and Framework of Cooperative Perception: From Heterogeneous Singleton to Hierarchical Cooperation (2022)

Perceiving the environment is one of the most fundamental keys to enabling Cooperative Driving Automation (CDA), which is regarded as the revolutionary solution to addressing the safety, mobility, and sustainability issues of contemporary transportation systems. Although an unprecedented evolution is now happening in the area of computer vision for object perception, state-of-the-art perception methods are still struggling with sophisticated real-world traffic environments due to the inevitably physical occlusion and limited receptive field of single-vehicle systems. Based on multiple spatially separated perception nodes, Cooperative Perception (CP) is born to unlock the bottleneck of perception for driving automation. In this paper, we comprehensively review and analyze the research progress on CP and, to the best of our knowledge, this is the first time to propose a unified CP framework. Architectures and taxonomy of CP systems based on different types of sensors are reviewed to show a high-level description of the workflow and different structures for CP systems. Node structure, sensor modality, and fusion schemes are reviewed and analyzed with comprehensive literature to provide detailed explanations of specific methods. A Hierarchical CP framework is proposed, followed by a review of existing Datasets and Simulators to sketch an overall landscape of CP. Discussion highlights the current opportunities, open challenges, and anticipated future trends.