gebhart/patrepeval huggingface dataset:
031 Collagenase Injection Into the Peyronie’s Disease-Like Plaque in A Rat Model Reduces not Just Plaque Size, but Selectively Myofibroblast Content, and is Associated With Increased Apoptosis, Replicating the Effects of A PDE5 Inhibitor Given Separately, but not in Combination (2016)

Journal Article 031 Collagenase Injection Into the Peyronie's Disease-Like Plaque in A Rat Model Reduces not Just Plaque Size, but Selectively Myofibroblast Content, and is Associated With Increased Apoptosis, Replicating the Effects of A PDE5 Inhibitor Given Separately, but not in Combination Get access I. Kovanecz, I. Kovanecz UCLA School of Medicine, United States Search for other works by this author on: Oxford Academic Google Scholar M. Masouminia, M. Masouminia LABioMed at Harbor UCLA Medical Center, United States Search for other works by this author on: Oxford Academic Google Scholar K. Nguyen, K. Nguyen LABioMed at Harbor UCLA Me Search for other works by this author on: Oxford Academic Google Scholar J. Rajfer, J. Rajfer UCLA School of Medicine, United States Search for other works by this author on: Oxford Academic Google Scholar N. Gonzalez-Cadavid N. Gonzalez-Cadavid UCLA School of Medicine, United States Search for other works by this author on: Oxford Academic Google Scholar The Journal of Sexual Medicine, Volume 14, Issue Supplement_1, January 2017, Pages S14–S15, https://doi.org/10.1016/j.jsxm.2016.11.033 Published: 01 January 2017
Printer Identification Based on Texture Features (2004)

In today's digital world securing different forms of content is very important in terms of protecting copyright and verifying authenticity. Many techniques have been developed to protect audio, video, digital documents, images, and programs (executable code). One example is watermarking of digital audio and images. We believe that a similar type of protection for printed documents is very important. In this paper we describe the use of image texture analysis to identify the printer used to print a document. In particular we will describe a set of features that can be used to provide forensic information about a document. We will demonstrate our methods using 10 EP printers.
Stability and Surface Topography Evolution in Nanoimprinted Polymer Patterns under a Thermal Gradient (2010)

Nanostructures created in polymer films by nanoimprint lithography are subject to large stresses, both those from the imprinting processes as well as stresses arising from the intrinsic thermodynamic instabilities. These stresses can induce nanostructure deformations that compromise the intended function of the imprinted pattern. Controlling these stresses, and thus the stability of the imprinted patterns, is a key scientific issue for this technology. The requirement of film stability against dewetting requires the use of entangled polymer films, which necessitates an understanding of complex viscoelastic response of these materials to large stresses. Here we investigate the evolution of the surface topography of nanoimprinted patterns in polystyrene films through a high throughput annealing approach in which the patterns are annealed for a fixed time on a controlled temperature gradient. Using principles of time−temperature superposition we systematically explore the effect of varying basic system variables such as pattern feature size, polymer molecular mass, imprinting temperature, on nanopattern stability, and on the evolution of imprinted patterns driven by surface tension and internal stress. Nanostructure collapse generally occurs through a combination of a “slumping” instability, where the imprinted film simply relaxes toward a planar film and the pattern height decreases with time, and a lateral “zigzag” instability in the nanoimprinted lines.
Universal Non-Polar Switching in Carbon-doped Transition Metal Oxides (TMOs) and Post TMOs (2022)

Transition metal oxides (TMOs) and post-TMOs (PTMOs), when doped with Carbon, show non-volatile current-voltage (I-V) characteristics, which are both universal and repeatable. We have shown spectroscopic evidence of the introduction of carbon-based impurity states inside the existing larger bandgap effectively creating a smaller bandgap which we suggest could enable Mott-like correlation effect. Our findings indicate new insights for yet to be understood unipolar and nonpolar resistive switching in the TMOs and PTMOs. We have shown that device switching is not thermal-energy dependent and have developed an electronic-dominated switching model that allows for the extreme temperature operation (from 1.5 K to 423 K) and state retention up to 673 K for a 1-hour bake. Importantly, we have optimized the technology in an industrial process and demonstrated integrated 1-transistor/1-resistor (1T1R) arrays up to 1 kbit with 47 nm devices on 300 mm wafers for advanced node CMOS-compatible correlated electron RAM (CeRAM). These devices are shown to operate with 2 ns write pulses and retain the memory states up to 200 C for 24 hours. The collection of attributes shown, including scalability to state-of-the-art dimensions, non-volatile operation to extreme low and high temperatures, fast write, and reduced stochasticity as compared to filamentary memories such as ReRAMs show the potential for a highly capable two-terminal back-end-of-line non-volatile memory.
Estimating Multiple Target Locations in Multi-Path Environments (2014)

This paper addresses the problem of multi-target localization with distributed multiple-input-multiple-output (MIMO) radar systems without angular resolution capability-i.e., only based on the measurements of the signal propagation delays. In particular, we address the case that multiple targets cannot be distinguished by their “signatures” or other unique characteristics. Further complications in realistic settings arise from the following factors: 1) the direct path (DP) between transmitter/receiver and target might be blocked, and 2) indirect paths (IPs) arising from multi path propagation might be present. We present in this paper a novel algorithm that can accurately localize multiple targets even under these difficult circumstances. This algorithm is based on an iterative approximation to an exhaustive maximum likelihood (EML) estimation of the target locations, yet avoiding the exponential complexity that an EML requires. It utilizes a clustering technique that gives the number and locations of targets, and incorporates an IP detection mechanism based on the likelihood of several propagation delay measurement (PDM) correspond to DPs from the same target. Despite its lower complexity, our algorithm achieves almost the same performance as the EML in a variety of simulation settings. We finally study the choice of algorithm parameters and the configurations of the MIMO system nodes to achieve the best localization performance.
Diffractive doublets corrected at two wavelengths (1991)

We present a complete theory for purely diffractive doublets corrected at two wavelengths. First we describe a class of diffractive doublets that can accomplish real imaging from one object point to one image point in two colors. The paraxial model of the design is also presented. Then we evaluate the performance of this class of doublets, comparing them with refractive singlets, hybrid (refractive–diffractive) singlets, and diffractive doublets based on Fresnel phase lenses. The class has a usable bandwidth that is approximately an order of magnitude better than the conventional Fresnel design.
Cationized Molecule (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Lipid Based Therapy for Ulcerative Colitis—Modulation of Intestinal Mucus Membrane Phospholipids as a Tool to Influence Inflammation (2010)

Ulcerative colitis (UC) is the result of an inappropriate colonic inflammatory response triggered by environmental and genetic factors. We have recently shown that mucus from UC patients has a decreased phosphatidylcholine (PC) content, while clinical trials revealed that therapeutic addition of PC to the colonic mucus alleviated the inflammatory activity. The mechanisms behind this are still unclear. We hypothesized that PC has at least two possible functions in the intestine: First, it establishes the surface hydrophobicity of the mucus and therefore protects the underlying tissue against intraluminal aggressors; recent experiments on surgical specimens revealed reduced surface tension and hydrophobicity in UC patients. Second, mucus phospholipids might also be integrated into the plasma membranes of enterocytes and thereby influence the signaling state of the mucosa. PC has been shown to inhibit TNF-α induced pro-inflammatory responses including: (1) assembly of plasma membrane actin; (2) activation of MAP kinases ERK and p38; and (3) activation of NF-κB and synthesis of pro-inflammatory gene products. Other phospholipids like phosphatidylethanolamine or sphingomyelin had no effect. PC also inhibited latex bead phagosome actin assembly, killing of M. tuberculosis in macrophages, and sphingosine-1-phosphate induced actin assembly in macrophages. Collectively, these results provide a molecular foundation that shows PC, firstly, as an anti-inflammatory, and secondly, as a surface hydrophobicity increasing compound with promising therapeutic potential in the treatment of inflammatory bowel disease.
Mouse monoclonal antibodies induced by anti‐allotype antibody display internal images of the rabbit VHa1 allotype: Direct visualization by immunoelectron microscopy (1986)

We have previously shown that injection of adult rabbits with anti-immunoglobulin (Ig) antibody (Ab) induces the expression of genetically unexpected Ig markers, i.e., a1 allotypic determinants. We now show that these rabbit Ig markers can also be induced in mice by a similar treatment; in the latter case the a1 determinants are located in the antigen-combining site and thus represent "internal images". Two monoclonal antibodies (mAb) were developed from mice treated with anti-allotype Ab. These mAb were reactive with all homologous and heterologous anti-a1 Ab but not normal Ig; efficiently inhibited the binding of rabbit a1 Ig to anti-a1 Ab; and elicited the production of anti-allotype Ab when injected into normal mice. To determine whether the a1-like determinants on these mAb were located in the antigen-combining site, immunoelectron microscopy was utilized to directly visualize Ab complexes. Complexes composed of intact Ab and anti-a1 Fab fragments yielded uniform binding patterns which were identical to those produced by anti-idiotypic reactions. In each case, an identical tip-to-tip binding configuration was observed with a single Fab fragment attached at an approximate 180 degree angle to the V region terminus of each Ab arm. In contrast, rabbit a1 Ig bound as many as two anti-a1 fragments per Ig arm; these fragments were attached laterally and at right angles to the intact molecule. These mAb thus provide the first direct evidence that Ab2 beta determinants are located in, or near, the antigen-combining site.
High-sensitivity lumped-element bandpass modulators in LiNbO/sub 3/ (1989)

Th design and evaluation of high-sensitivity lumped-element, bandpass modulators based on the integrated-optical Mach-Zehnder interferometer are presented. The optimum impedance-matched modulator response is formulated. Then a passive resonant drive circuit that achieves this response is described. In contrast to the usual baseband case, the maximum response of the impedance-matched modulator is independent of modulator length. Experimental results are given for several modulators built in lithium niobate using this circuit. Undesirable acoustic resonances are observed, and a technique for their suppression is demonstrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The novel mAb QR6.6 detects a surface molecule on immature thymocytes and inhibits their proliferation on thymic epithelial cells. (1994)

We previously reported that the nude mouse-derived splenic T cell clone N-9F exhibits a proliferative response when cultured on thymic stromal cells. This N-9F proliferation is mediated by direct cell-to-cell interactions between T and thymic stromal cells. A thymic epithelial cell clone, SL10.3, also supports N-9F growth. To identify the molecule involved in T cell development in the thymus, we established mAb specific to the N-9F clone. One of these mAb, QR6.6, was found to inhibit the N-9F proliferative response on SL10.3. QR6.6-positive cells were detected in thymus but not in other lymphoid organs such as bone marrow, lymph nodes, or spleen. QR6.6-positive cells accounted for 3 to 5% of the cells in adult thymuses whereas higher percentages were found in neonatal (10-20%) and fetal thymuses (70% at E17 and 10-20% at E15). The positive cells were primarily CD4-8- thymocytes in fetuses and CD4-8- to CD4+8+ thymocytes in adults. The QR6.6 mAb precipitates a 100 kDa molecule from the N-9F clone. The addition of the mAb to fetal thymus organ culture reduces the recovery of cells at culture day 4. It was also found that the mAb inhibits fetal thymocyte proliferation on the SL10.3 thymic epithelial cell line. These results suggest that the 100 kDa molecule detected by the QR6.6 mAb may play a crucial role in the early stage of thymocyte development.
A dynamically-reconfigurable image recognition processor (2004)

Summary form only given. We introduce a new image recognition processor using a run-time reconfiguration (RTR) technology. A phase impulse response function (PIRF) is employed as an application for evaluating the performance of RTR architecture. By utilizing the RTR architecture effectively, a complicated image processing application such as PIRF can be implemented on a single processor. To achieve this, a dynamically-reconfigurable arithmetic logic unit (DRALU) is proposed. Simulation results show that our proposed processor using DRALU can execute the PIRF within 30 msec.
Electromagnetic Analysis of Cloaking Metamaterial Structures (2008)

We study cylindrical and spherical shell structures that have cloaking material properties proposed by Pendry et al. We use 2D and 3D time-harmonic analysis to study the field distribution and power flow for various arrangements of these structures. We show that the intrinsic field directing properties of these structures enable interesting and useful field manipulation including reflection, enhancement and shielding over separate spatial regions.
Electrochemical deposition: Small 13/2009 (2009)

The frontispiece shows living B lymphocytes captured on a microcantilever-arrayed biochip. Antibodies targeting cellular antigens are pyrrole modified and then electropolymerized into polypyrrole films on a gold surface. The arrayed feature size is close to a lymphocyte size and thus allows efficient cell capture and organization. Gold layers can thus be arrayed in a predetermined manner, which give access to organized blood cells on surfaces. Each line is separated from the other by 50 µm. For more information, please read the Communication “Individual Blood-Cell Capture and 2D Organization on Microarrays” by Y. Roupioz, L. Nicu, et al., beginning on page 1492.
Theranostic Nanomedicine (2011)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTTheranostic NanomedicineXiaoyuan Chen, Sanjiv S. Gambhir, and Jinwoo CheonView Author Information National Institutes of Health Stanford University Yonsei UniversityCite this: Acc. Chem. Res. 2011, 44, 10, 841Publication Date (Web):October 18, 2011Publication History Published online18 October 2011Published inissue 18 October 2011https://doi.org/10.1021/ar200231dCopyright © 2011 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views7433Altmetric-Citations161LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (528 KB) Get e-AlertscloseSUBJECTS:Biological imaging,Drug delivery,Gene therapy,Nanoparticles,Theranostics Get e-Alerts
Unveiling Stimulation Secrets of Electrical Excitation of Neural Tissue Using a Circuit Probability Theory (2018)

A new theory, named the Circuit-Probability theory, is proposed to unveil the secret of electrical nerve stimulation, essentially explain the nonlinear and resonant phenomena observed when neural and non-neural tissues are electrically stimulated. For the explanation of frequency dependent response, an inductor is involved in the neural circuit model. Furthermore, predicted response to varied stimulation strength is calculated stochastically. Based on this theory, many empirical models, such as strength-duration relationship and LNP model, can be theoretically explained, derived, and amended. This theory can explain the complex nonlinear interactions in electrical stimulation and fit in vivo experiment data on stimulation-responses of many experiments. As such, the C-P theory should be able to guide novel experiments and more importantly, offer an in-depth physical understanding of the neural tissue. As a promising neural model, we can even further explore the more accurate circuit configuration and probability equation to better describe the electrical stimulation of neural tissues in the future.
Associations of diet and lifestyle factors with common volatile organic compounds in exhaled breath of average-risk individuals (2018)

Factors potentially modifying the composition of exhaled breath, such as dietary factors, deserve careful attention in the design and analysis of studies accessing the use of VOCs as diagnostic markers.
Enhanced orbital magnetic moments in magnetic heterostructures with interface perpendicular magnetic anisotropy (2015)

We have studied the magnetic layer thickness dependence of the orbital magnetic moment in magnetic heterostructures to identify contributions from interfaces. Three different heterostructures, Ta/CoFeB/MgO, Pt/Co/AlO$_x$ and Pt/Co/Pt, which possess significant interface contribution to the perpendicular magnetic anisotropy, are studied as model systems. X-ray magnetic circular dichroism spectroscopy is used to evaluate the relative orbital moment, i.e. the ratio of the orbital to spin moments, of the magnetic elements constituting the heterostructures. We find that the relative orbital moment of Co in Pt/Co/Pt remains constant against its thickness whereas the moment increases with decreasing Co layer thickness for Pt/Co/AlO$_x$, suggesting that a non-zero interface orbital moment exists for the latter system. For Ta/CoFeB/MgO, a non-zero interface orbital moment is found only for Fe. X-ray absorption spectra shows that a particular oxidized Co state in Pt/Co/AlO$_x$, absent in other heterosturctures, may give rise to the interface orbital moment in this system. These results show element specific contributions to the interface orbital magnetic moments in ultrathin magnetic heterostructures.
Session 11 overview: Sensors and imagers for life sciences: IMMD subcommittee (2015)

Life sciences applications require imaging in different modalities, e.g., fluorescence, positron imaging, near-IR, with higher sensitivity, higher speed, and smaller form factor. This session includes two papers that achieve significant milestones in fluorescence lifetime imaging with low picosecond resolution. Two other papers describe advances in positron emission tomography and functional near-IR medical imaging. Another major accomplishment is the demonstration of time-correlated photon counting with 14GS/S throughput. Finally, an intriguing technique for improving CMRR in neural recording, an enabling multi-modal cell-based drug screening assay platform, and a consumer-oriented ultrasound body fat sensor, enable advances in their respective fields.
A Divalent Metal Site in the Small Subunit of the Manganese-Dependent Ribonucleotide Reductase of Corynebacterium ammoniagenes (1998)

Based on its metallo-cofactor, the manganese-dependent ribonucleotide reductase (Mn-RRase) responsible for delivery of DNA precursors in the Mn-requiring Gram-positive bacterium Corynebacterium (formerly Brevibacterium) ammoniagenes ATCC 6872 is no longer considered as a simple analogue of the aerobic Fe-RRase of Escherichia coli but as the prototype of the class IV enzymes (1). Deliberate dissociation of the Mn-RRase holoenzyme and an improved sample preparation of the dimeric CA2 protein allowed further characterization of the inherent metallo-cofactor by Q-band electron paramagnetic resonance (EPR) spectroscopy. At 40 K, a distinct hyperfine sextet (I = 5/2,55Mn) pattern with a weak zero-field splitting was detected in the CA2 protein prepared from manganese-sufficient cells displaying high RRase activity as expected. This Q-band Mn(II) signal was absent in the apo-CA2 protein obtained from manganese-depleted cells devoid of this enzymatic activity. The presence of a mixed valence manganese cluster in the C. ammoniagenes RRase is excluded since no complex multiline EPR signals were detected in the CA2 protein even at very low (8 K) temperature. The observed Mn(II) spectrum indicates a protein-bound manganese which was modified in the presence of 5.7 mM p-methoxyphenol, but is insensitive toward 10 mM EDTA. Thus, the manganese appeared to be either strictly bound or buried within a hydrophobic pocket of the CA2 protein, inaccessible for EDTA.