gebhart/patrepeval huggingface dataset:
OPA1 R445H mutation in optic atrophy associated with sensorineural deafness (2005)

The heterozygous R445H mutation in OPA1 was found in five patients with optic atrophy and deafness. Audiometry suggested that the sensorineural deafness resulted from auditory neuropathy. Skin fibroblasts showed hyperfragmentation of the mitochondrial network, decreased mitochondrial membrane potential, and adenosine triphosphate synthesis defect. In addition, OPA1 was found to be widely expressed in the sensory and neural cochlear cells of the guinea pig. Thus, optic atrophy and deafness may be related to energy defects due to a fragmented mitochondrial network.
Automatic Neural Network Search Method for Open Set Recognition (2019)

Real-world recognition or classification tasks in computer vision are not apparent in controlled environments and often get involved in open set. Previous research work on real-world recognition problem is knowledge- and labor-intensive to pursue good performance for there are numbers of task domains. Auto Machine Learning (AutoML) approaches supply an easier way to apply advanced machine learning technologies, reduce the demand for experienced human experts and improve classification performance on close set. This paper proposes an automatic neural network search method for designing effective convolution neural network (CNN) models for open set recognition (OSR). Feature distribution information is explicitly incorporated into the main objective. So during the search process, the sampled models will enlarge interclass differences and reduce intra-class variations. We design a flexible search space based on classic CNN models to diversify neural architectures and also add some search principles to limit the size of the search space. Experimental results on CIFAR-10 and Dunhuang historical Chinese datasets show that our approach improves performances on both close and open set. Comparing with the other two OSR algorithms, our method also achieves the best performance.
13C enrichment of extracellular neurotransmitter glutamate in rat brain--combined mass spectrometry and NMR studies of neurotransmitter turnover and uptake into glia in vivo. (2003)

13C-enrichment analysis of glutamate in the extracellular fluid (GLU(ECF): 2-3 microM) by gas-chromatography/mass-spectrometry (GCMS) was combined with in vivo NMR observation of whole-brain GLU (approximately10 mM) to study neurotransmitter uptake. Brain GLU C5 was 13C-enriched by intravenous [2,5-13C]glucose infusion. GLU(ECF) was collected by microdialysis from the cortico-striatal region of awake rats. The 13C-enrichment of basal dialysate GLU C5 during 0.75-1.25 hr of infusion was 0.263 +/- 0.01, very close to the enrichment of whole-brain GLU C5. The result strongly suggests that dialysate GLU consists predominantly of neurotransmitter GLU. For selective 13C-enrichment of neurotransmitter GLU, the whole-brain 13C-enrichment was followed by [12C]glucose infusion to chase 13C from the small glial GLU pool. This leaves [5-13C]GLU mainly in the large neuronal metabolic pool and the vesicular neurotransmitter pool. The uptake of synaptic [5-13C]GLU(ECF) into glia and metabolism to glutamine (GLN) were monitored in vivo by NMR observation of [5-13C,15N]GLN formed during 15NH4Ac infusion. The rate of GLN synthesis, derived from neurotransmitter GLU(ECF) (which provided 80-90% of the substrate) was 6.4 +/- 0.44 micromol/g/hr. Hence, the observed rate represents a reasonable estimate for the rate of glial uptake of GLU(ECF), a process that is crucial for protecting the brain from GLU excitotoxicity.
Pessimistic explanatory style (2010)

Seligman's theory of causal attribution predicts that patients with a pessimistic explanatory style will have less favourable health outcomes. We identified 702 patients who had undergone 894 primary total knee replacements between 1993 and 2005, who responded to follow-up surveys at two (n = 783 knee replacements) and/or five years (n = 443 knee replacements) and had also completed the Minnesota Multiphasic Personality Inventory long before the joint replacement (median = 16.6 and 14.5 years for two- and five-year cohorts, respectively). Scores from the Minnesota Multiphasic Personality Inventory Optimism-Pessimism scale were used to categorise patients as pessimistic (t-score > 60) or non-pessimistic (t-score < or = 60). Multivariate logistic regression models assessing the effect of pessimistic explanatory style on pain or improvement in knee function were adjusted for gender, age, distance from the place of treatment and depression score. Pessimists reported (a) significantly more moderate or severe pain at two years with odds ratio 2.21 (95% confidence interval (CI) 1.12 to 4.35; p = 0.02), but not at five years when the odds ratio was 1.21 (95% CI 0.51 to 2.83; p = 0.67); and (b) less improvement in knee function at two years when the odds ratio was 0.53 (95% CI 0.30 to 0.96; p = 0.04), but not at five years when the odds ratio was 1.26 (95% CI 0.57 to 2.77; p = 0.57). No significant associations with moderate or severe limitation of activity were seen at two or five years. We conclude that a pessimistic explanatory style is associated with worse pain and functional outcomes two years after total knee replacement.
Optical Buffer Based on Monolithic InP Phased-Array 1×16 Switch with Silica-PLC Pitch Converter and Ultra-Compact Coiled Fiber Delay Lines (2010)

We demonstrate large-capacity high-resolution optical buffer, comprising 1×16 InP switch and ultra-compact delay lines based on thin-cladding highly nonlinear fibers. Silica-PLC-based pitch converter is employed to realize uniform coupling from all 16 switch ports simultaneously.
Zolmitriptan is Effective for the Treatment of Persistent and Recurrent Migraine Headache (1999)

Zolmitriptan is a 5-HT1B/1D receptor agonist for the acute treatment of migraine. This study examined the efficacy of a second dose of zolmitriptan for the treatment of persistent or recurrent headache. Part 1 was a randomised, placebo-controlled, double-blind evaluation of 2.5 mg and 5 mg zolmitriptan for the treatment of persistent migraine headache, two hours after an initial dose of 2.5 mg zolmitriptan. In part 2 (open-label), patients treated the first two attacks with 2.5 mg zolmitriptan, thereafter patients could treat any initial, persistent or recurrent migraine headache with 2.5 mg or 5 mg zolmitriptan. The unique design of this trial allowed patients to adjust their treatment to attain maximum headache relief and control of their disease. Of 2800 patients treating an initial migraine headache in Part 1, 989 patients took a second dose to treat persistent headache of moderate or severe intensity. Headache response rates were similar across the three treatment groups, but the pain-free response rate was significantly higher with 5 mg zolmitriptan than with placebo (p < 0.001). In Part 2, 2499 patients treated 49,784 migraine attacks (excluding the first two attacks, which had to be treated with 2.5 mg zolmitriptan), of which 66% required only a single dose of zolmitriptan. Patients treated 22% of attacks with a second dose of zolmitriptan for persistent headache. A headache response was achieved in 80% and 73% of persistent headaches treated with 2.5 mg or 5 mg zolmitriptan, respectively. Corresponding pain-free responses following treatment of persistent headaches of any intensity were 64% and 52%. Eight per cent of attacks were treated with a second dose of zolmitriptan for moderate or severe recurrent headache. A headache response was achieved in 90% and 86% of moderate/severe attacks, with a pain-free response in 78% and 70% of attacks of any intensity treated with 2.5 mg and 5 mg, respectively. Zolmitriptan was well tolerated. In conclusion, 2.5 mg and 5 mg zolmitriptan are highly effective in treating both persistent and recurrent migraine headache.
Using email to facilitate wiki-based coordinated, collaborative authoring (2011)

Dandelion is a wiki-based tool that supports coordinated, collaborative authoring. In this paper, we present an ex-tended version of Dandelion, which provides an email inter-face for users to accomplish their tasks by email in a coordinated, collaborative authoring process. Specifically, Dandelion employs a semi-structured, template-based approach that allows users to use templates to specify their requests in email. These emailed requests can be interpreted by Dandelion and are then used to automatically drive the collaboration flow. As part of its actions, Dandelion automatically creates a wiki page and dynamically updates it to record co-authoring tasks and collate co-authored content. As a result, users can use their familiar tool (email) to accomplish their tasks in a co-authoring process, while leveraging a wiki for additional benefits (e.g., obtaining collaboration awareness and formatting the text). Our preliminary study with two groups of users shows the usefulness of both Dandelion email and wiki features and their impact on collaboration effectiveness.
A Convenient Synthesis of 3-Aryl Coumarins (1987)

A new, convenient, one-step synthesis o f 3-aryl cwmarins frwn 2-fluorobenzaldehyde and aryl acetic acids i s reported.Since cwmarins occur widely i n p l a n t source^.^there e x i s t s considerable i n t e r e s t i n synthetic approaches t o t h i s heterocylic system.Several general and d i r e c t synthetic routes have been extensivelyThe more important methods f o r coumarin synthesis include the Pechmann reaction5 between a phenol and a 8-keto ester, the Knoevenagel reaction6 and Perkin reactions 7 between an o-hydroxybenraldehyde and an active k t h y l e n e compound.A11 o f these major methods presumably involve incorporation o f a phenolic oxygen as the ring-oxygen i n the coumarin product since they formally involve r i n g closure of 2-hydroxycinnamic acids o r r e l a t e d intermediates.Ue have successfully used a modified Perkin condensation t o synthesize a large number of o-(2-thieny1)-4-substituted cinnamic a ~i d s .~-l l Hwever, i t was found, i n connection w i t h another study, t h a t during the attempted preparation of a-(2-thieny1)-2-fluorocinnamic acid from the reaction o f 2-fluorobenraldehyde and 2-thiophene acetic acid i n the presence o f triethylamine i n acetic anhydride t h a t 3-(2-thieny1)coumarin (1) i s f o m d .That the reaction product was the cournarin 1 was demonstrated by i t s ms data.13c, 170 and 'H nmr data, i r data, elemental analys i s and the melting Point of the compwnd was i n agreement with the l i t e r a t u r e value.12The 170 nmr spectroscopic data w i t h signals a t 348 and 219 ppn were p a r t i c u l a r l y useful i n the charact e r i z a t i o n o f 1 as a caumarin.13I n expanding upon t h i s discovery, i t has been found that the sequence outlined i n Scheme I i s general For aryl acetic acids.Table I contains a l i s t i n g of the 3-aryl coumarins which have been prepared by t h i s method.
Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals (2021)

Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI (Z = 2.73, p = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.
Control Plane Protocols (2009)

The control plane of the Access Stratum (AS) handles radio-specific functionality. This chapter first explains the mechanisms for transmission and update of System Information. The AS procedures are then described in the context of the two Radio Resource Control (RRC) states of an LTE UE – RRC_IDLE and RRC_CONNECTED. RRC_CONNECTED procedures include the activation of security and management of security keys, connection establishment, Data Radio Bearer (DRB) establishment and control of mobility, all of which are explained in detail. Mobility both within LTE and to/from other radio access technologies is also covered, including an introduction to the configuration of measurements used to support such mobility. The main AS procedures for RRC_IDLE UEs relate to PLMN and cell selection, mobility and paging. The relevant measurements in idle mode are explained, as are cell access restrictions and prioritization for cell selection.
Antiviral Action of Polyadenylic-Polyuridylic Acid Against HIV in Cell Cultures (1992)

Polyadenylic-polyuridylic acid referred to as poly(A).poly(U) is a synthetic double-stranded RNA which has been shown to manifest both antitumoral and immunomodulatory activities. Here we used this agent to demonstrate its antiviral activity against the human immunodeficiency virus (HIV-1 and HIV-2). Treatment of cells with poly(A).poly(U) resulted in a significant delay in the development of the HIV-specific cytopathic effect characterized by the formation of syncytia and cell lysis. Furthermore, the production of virus measured by the concentration of the HIV major core protein was reduced by 90-95%. Under these experimental conditions, the synthesis of HIV proteins was reduced at least tenfold whereas the metabolism and proliferation of cells apparently were not affected. The inhibitory action of poly(A).poly(U) seems to be at the level of viral entry into cells. Combined treatment of infected cells with poly(A).poly(U) and azidothymidine (AZT) resulted in a 4-5-fold synergistic inhibitory effect. Previously, no toxicity has been observed in cancer patients with long-term treatment with poly(A).poly(U). In view of this and the significant anti-HIV effect, poly(A).poly(U) provides a potential candidate as a therapeutic drug in AIDS disease.
Diode-pumped ytterbium-doped Sr/sub 5/(PO/sub 4/)/sub 3/F laser performance (1996)

The performance of the first diode-pumped Yb/sup 3+/-doped Sr/sub 5/(PO/sub 4/)/sub 3/F (Yb:S-FAP) solid-state laser is discussed. An InGaAs diode array has been fabricated that has suitable specifications for pumping a 3/spl times/3/spl times/30 mm Yb:S-FAP rod. The saturation fluence for diode pumping was deduced to be 5.5 J/cm/sup 2/ for the particular 2.8 kW peak power diode array utilized in our studies. This is 2.5/spl times/ higher than the intrinsic 2.2 J/cm/sup 2/ saturation fluence as is attributed to the 6.5 nm bandwidth of our diode pump array. The small signal gain is consistent with the previously measured emission cross section of 6.0/spl times/10/sup -20/ cm/sup 2/, obtained from a narrowband-laser pumped gain experiment. Up to 1.7 J/cm/sup 3/ of stored energy density was achieved in a 6/spl times/6/spl times/44 mm Yb:S-FAP amplifier rod. In a free running configuration, diode-pumped slope efficiencies up to 43% (laser output energy/absorbed pump energy) were observed with output energies up to /spl sim/0.5 J per 1 ms pulse. When the rod was mounted in a copper block for cooling, 13 W of average power was produced with power supply limited operation at 70 Hz with 500 /spl mu/s pulses.
Stability analysis of nonlinear current-sharing techniques (2002)

This paper addresses the dynamic analysis of paralleled power converter systems employing nonlinear load-sharing control techniques. The first section of the paper analyzes nonlinear load-sharing control techniques which are linearizable about a constant operating point. The second section of the paper analyzes the dynamics of the widely-used UC3907 control scheme for an important special case. In both cases, the analyses are validated against experimental results.
Acoustic Echo Cancellation Employing Delayless Subband Adaptive Filters (1996)

The use of hands-free communication in cars, computer applications and video conferencing has created a demand for high-quality acoustic echo cancellation. In these applications these acoustic channel has typically a long impulse response in the order of 100ms. Typical lengths of adaptive FIR-filters can be 500-1500 taps. In order to reduce the complexity and also to improve the convergence rate, subband processing schemes have been suggested. This paper presents an implementation of a delayless subband adaptive filter. The study shows a possible suppression of about 30 dB and also a more rapid convergence compared to a fullband LMS-filter.
Multistability analysis of phase locking patterns in an excitatory coupled neural system (1999)

We quantitatively analyze the multistability of dynamic patterns of a bursting neural system with diffusive coupling. Through effective coupling analysis, we show that the system is not in-phase locking but exhibits various phase locking patterns, each of which corresponds to the stable fixed points of the effective coupling. The simulation proves the validity of the effective coupling method in analyzing the multistability of neural systems which presents complicated dynamic patterns such as bursting.
Statistical estimation of white matter microstructure from conventional MRI (2016)

Diffusion tensor imaging (DTI) has become the predominant modality for studying white matter integrity in multiple sclerosis (MS) and other neurological disorders. Unfortunately, the use of DTI-based biomarkers in large multi-center studies is hindered by systematic biases that confound the study of disease-related changes. Furthermore, the site-to-site variability in multi-center studies is significantly higher for DTI than that for conventional MRI-based markers. In our study, we apply the Quantitative MR Estimation Employing Normalization (QuEEN) model to estimate the four DTI measures: MD, FA, RD, and AD. QuEEN uses a voxel-wise generalized additive regression model to relate the normalized intensities of one or more conventional MRI modalities to a quantitative modality, such as DTI. We assess the accuracy of the models by comparing the prediction error of estimated DTI images to the scan-rescan error in subjects with two sets of scans. Across the four DTI measures, the performance of the models is not consistent: Both MD and RD estimations appear to be quite accurate, while AD estimation is less accurate than MD and RD; the accuracy of FA estimation is poor. Thus, in some cases when assessing white matter integrity, it may be sufficient to acquire conventional MRI sequences alone.
Securing conditional branches in the presence of fault attacks (2018)

In typical software, many comparisons and subsequent branch operations are highly critical in terms of security. Examples include password checks, signature checks, secure boot, and user privilege checks. For embedded devices, these security-critical branches are a preferred target of fault attacks as a single bit flip or skipping a single instruction can lead to complete access to a system. In the past, numerous redundancy schemes have been proposed in order to provide control-flow-integrity (CFI) and to enable error detection on processed data. However, current countermeasures for general purpose software do not provide protection mechanisms for conditional branches. Hence, critical branches are in practice often simply duplicated. We present a generic approach to protect conditional branches, which links an encoding-based comparison result with the redundancy of CFI protection mechanisms. The presented approach can be used for all types of data encodings and CFI mechanisms and maintains their error-detection capabilities throughout all steps of a conditional branch. We demonstrate our approach by realizing an encoded comparison based on AN-codes, which is a frequently used encoding scheme to detect errors on data during arithmetic operations. We extended the LLVM compiler so that standard code and conditional branches can be protected automatically and analyze its security. Our design shows that the overhead in terms of size and runtime is lower than state-of-the-art duplication schemes.
Ulkomaalaistaustaisten nuorten koulunkäynti ja peruskoulun jälkeinen opiskelu (2018)

Kotoutumisen seurannassa tarvitaan
Direct excitation of parvalbumin‐positive interneurons by M1 muscarinic acetylcholine receptors: roles in cellular excitability, inhibitory transmission and cognition (2014)

Parvalbumin-containing (PV) neurons, a major class of GABAergic interneurons, are essential circuit elements of learning networks. As levels of acetylcholine rise during active learning tasks, PV neurons become increasingly engaged in network dynamics. Conversely, impairment of either cholinergic or PV interneuron function induces learning deficits. Here, we examined PV interneurons in hippocampus (HC) and prefrontal cortex (PFC) and their modulation by muscarinic acetylcholine receptors (mAChRs). HC PV cells, visualized by crossing PV-CRE mice with Rosa26YFP mice, were anatomically identified as basket cells and PV bistratified cells in the stratum pyramidale; in stratum oriens, HC PV cells were electrophysiologically distinct from somatostatin-containing cells. With glutamatergic transmission pharmacologically blocked, mAChR activation enhanced PV cell excitability in both CA1 HC and PFC; however, CA1 HC PV cells exhibited a stronger postsynaptic depolarization than PFC PV cells. To delete M1 mAChRs genetically from PV interneurons, we created PV-M1 knockout mice by crossing PV-CRE and floxed M1 mice. The elimination of M1 mAChRs from PV cells diminished M1 mAChR immunoreactivity and muscarinic excitation of HC PV cells. Selective cholinergic activation of HC PV interneurons using Designer Receptors Exclusively Activated by Designer Drugs technology enhanced the frequency and amplitude of inhibitory synaptic currents in CA1 pyramidal cells. Finally, relative to wild-type controls, PV-M1 knockout mice exhibited impaired novel object recognition and, to a lesser extent, impaired spatial working memory, but reference memory remained intact. Therefore, the direct activation of M1 mAChRs on PV cells contributes to some forms of learning and memory.