gebhart/patrepeval huggingface dataset:
Quantum charge transport inMo6S3I6molecular wire circuits (2009)

Charge transport measurements on flexible ${\text{Mo}}_{6}{\text{S}}_{3}{\text{I}}_{6}$ (MoSI) nanowires with different diameters in highly imperfect two-terminal circuits reveal systematic power-law behavior of the conductivity $\ensuremath{\sigma}(T,V)$ as a function of temperature and voltage. On the basis of measurements on a number of circuits we conclude that the behavior in thin wires can be most convincingly described by tunneling through Tomonaga-Luttinger liquid segments of MoSI wire, which is in some cases modified by environmental Coulomb blockade. The latter are proposed to arise from deformations or imperfections of the MoSI wires, which---in combination with their recognitive terminal sulfur-based connectivity properties---might be useful for creating subnanometer scale interconnects as well as nonlinear elements for molecular electronics.
Algorithms for Communications Systems and Their Applications (2002)

Preface. Acknowledgements. Elements of signal theory. The Wiener filter and linear prediction. Adaptive transversal filters. Transmission media. Digital representation of waveforms. Modulation theory. Transmission over dispersive channels. Channel equilization and symbol detection. Orthogonal frequency division multiplexing. Spread spectrum systems. Channel codes. Trellis coded modulation. Precoding and coding techniques for dispersive channels. Synchronization. Self--training equalization. Applications of interference cancellation. Wired and wireless network technologies. Modulation techniques for wireless systems. Design of high speed transmission systems over unshielded twisted pair cables. Index.
The AGC Loop Filter (2017)

… the output (BM displacement or velocity) varies much less than the stapes input displacement or velocity, for frequencies near the best frequency. The significance of this important finding will become clearer as we proceed, but, in my opinion, it is a precursor to an automatic gain control system which seems to be built into the cochlear filters.—“Cochlear modeling—1980,” Jont B. Allen (1981)
ChemInform Abstract: Water and Alcohol Vapor Sensitivity and Calorimetric Study on Magnetic Octacyano‐Bridged Bimetallic Assemblies (2015)

Abstract Review: 89 refs.
Interleukin-2-Triggered Raf-1 Expression, Phosphorylation, and Associated Kinase Activity Increase through G 1 and S in CD3-Stimulated Primary Human T Cells (1991)

To gain further insight into the role of Raf-1 in normal cell growth, c-raf-1 mRNA expression, Raf-1 protein production, and Raf-1-associated kinase activity in normal human T cells were analyzed. In contrast to the constitutive expression of Raf-1 in continuously proliferating cell lines, c-raf-1 mRNA and Raf-1 protein levels were barely detectable in freshly isolated G0 T lymphocytes. Previous work with fibroblasts has suggested that Raf-1 plays a signaling role in the G0-G1 phase transition. In T cells, triggering via the T-cell antigen receptor (TCR)-CD3 complex (TCR/CD3) resulted in an approximately fourfold increase in c-raf-1 mRNA. In addition, the promotion of G1 progression by interleukin 2 (IL-2) was associated with a 5- to 10-fold immediate/early induction of c-raf-1 mRNA, resulting in up to a 12-fold increase in Raf-1 protein expression. TCR/CD3 activation did not alter the phosphorylation state of Raf-1, whereas interleukin 2 receptor stimulation resulted in a rapid increase in the phosphorylation state of a subpopulation of Raf-1 molecules progressively increasing throughout G1. These findings were complemented by assays for Raf-1-associated kinase activity which revealed a gradual accumulation of serine and threonine autokinase activity in Raf-1 immunoprecipitates during G1, which remained elevated throughout DNA replication.
Real-Time Estimation of Glenohumeral Joint Rotation Center With CAREX: A Cable-Based Arm Exoskeleton (2012)

In the past few years, the authors have proposed several prototypes of a Cable-driven upper ARm EXoskeleton (CAREX) for arm rehabilitation. The key advantages of CAREX over conventional exoskeletons are: (i) It is nearly an order of magnitude lighter. (ii) It does not have conventional links and joints, hence does not require joint axes alignment and segment lengths adjustment. (iii) It does not limit the natural degrees-of-freedom of the upper limb. (iv) The structure of the exoskeleton is novel as the cables are routed from the proximal to the distal segments of the arm. Preliminary experimental results with CAREX on a robotic arm and on healthy subjects have demonstrated the effectiveness of the exoskeleton within “assist-as-needed” training paradigm. In this paper, we propose a novel approach to estimate the glenohumeral joint rotation center (GH-c) using measurements of shoulder joint angles and cable lengths. This helps in locating the glenohumeral joint rotation center appropriately within the kinematic model. As a result, more accurate kinematic model can be used to improve the training of human users. An estimation algorithm is presented to compute the GH-c in real-time. The algorithm was implemented on the latest prototype of CAREX which controls four degrees-of-freedom of the shoulder and elbow. Preliminary experiments were performed on two healthy subjects under two different scenarios: (i) GH-c was assumed to be a fixed point and (ii) GH-c was estimated using the proposed algorithm. Experimental results are presented to compare the two scenarios.
Bright, NIR‐Emitting Au23 from Au25: Characterization and Applications Including Biolabeling (2009)

A novel interfacial route has been developed for the synthesis of a bright-red-emitting new subnanocluster, Au(23), by the core etching of a widely explored and more stable cluster, Au(25)SG(18) (in which SG is glutathione thiolate). A slight modification of this procedure results in the formation of two other known subnanoclusters, Au(22) and Au(33). Whereas Au(22) and Au(23) are water soluble and brightly fluorescent with quantum yields of 2.5 and 1.3 %, respectively, Au(33) is organic soluble and less fluorescent, with a quantum yield of 0.1 %. Au(23) exhibits quenching of fluorescence selectively in the presence of Cu(2+) ions and it can therefore be used as a metal-ion sensor. Aqueous- to organic-phase transfer of Au(23) has been carried out with fluorescence enhancement. Solvent dependency on the fluorescence of Au(23) before and after phase transfer has been studied extensively and the quantum yield of the cluster varies with the solvent used. The temperature response of Au(23) emission has been demonstrated. The inherent fluorescence of Au(23) was used for imaging human hepatoma cells by employing the avidin-biotin interaction.
CenterHMR: Multi-Person Center-based Human Mesh Recovery (2020)

This paper focuses on multi-person 3D mesh recovery from a single RGB image. Existing approaches predominantly follow a multi-stage pipeline, that detects bounding boxes and then regresses the body from bounding-box-level features. However, multi-person occlusion and truncation can make these features ambiguous, which results in the failure of recovery. To deal with this problem, we present a novel bottom-up single-shot method, named Center-based Human Mesh Recovery network (CenterHMR). The key idea is to develop an explicit center-based representation for bottom-up pixel-level estimation. Guided by the body centers, our model effectively locates every person and learns robust and discriminative features under occlusion. In an end-to-end manner, the model is trained to estimate multiple differentiable maps that contain the information of multi-person 3D body meshes and their locations.Furthermore, when encountering severe multi-person occlusion, the body centers may be very close or even overlapping. A collision-aware center representation is developed to ensure a distinguishable distance between body centers. Our proposed CenterHMR achieves state-of-the-art performance on four challenging multi-person/occlusion benchmarks (3DPW, CMU Panoptic, MuPoTs-3D, and 3DOH50K). Experiments on crowded/occluded datasets demonstrate the stability under various types of occlusion. Due to the concise bottom-up single-shot design, our released demo code (this https URL) is the first open-source real-time (over 30 FPS) implementation of monocular multi-person 3D mesh recovery.
Innovative Low Cost Cleaning Technique for PV Modules on Solar Tracker (2018)

This paper presents an innovative low cost cleaning technique for photovoltaic panels on a bi-axial solar tracking system from Helioslite. This competitive solution exploits the motion of the tracker and the gravity effect. The cleaning tests were carried out and validated using an optimal design of the cleaning system prototype. These have been achieved using a locally developed prototype of the Helioslite bi-axial tracker. As a perspective and before proceeding to the realization of the cleaning system in real dimensions, other tests should be conducted in order to ensure the effectiveness of this innovative cleaning system.
Cooperative Rate-Splitting for Secrecy Sum-Rate Enhancement in Multi-antenna Broadcast Channels (2020)

In this paper, we employ Cooperative Rate-Splitting (CRS) technique to enhance the Secrecy Sum Rate (SSR) for the Multiple Input Single Output (MISO) Broadcast Channel (BC), consisting of two legitimate users and one eavesdropper, with perfect Channel State Information (CSI) available at all nodes. For CRS based on the three-node relay channel, the transmitter splits and encodes the messages of legitimate users into common and private streams based on Rate-Splitting (RS). With the goal of maximizing SSR, the proposed CRS strategy opportunistically asks the relaying legitimate user to forward its decoded common message. During the transmission, the eavesdropper keeps wiretapping silently. To ensure secure transmission, the common message is used for the dual purpose, serving both as a desired message and Artificial Noise (AN) without consuming extra transmit power comparing to the conventional AN design. Taking into account the total power constraint and the Physical Layer (PHY) security, the precoders and timeslot allocation are jointly optimized by solving the nonconvex SSR maximization problem based on Sequential Convex Approximation (SCA) algorithm. Numerical results show that the proposed CRS secure transmission scheme outperforms existing Multi-User Linear Precoding (MU-LP) and Cooperative Non-Orthogonal Multiple Access (C-NOMA) strategies. Therefore, CRS is a promising strategy to enhance the PHY security in Multi-antenna BC systems.
Digital Biomarkers of Mobility in Parkinson’s Disease During Daily Living (2020)

Clinical studies and clinical practice with digital biomarkers of daily life mobility in PD should include turning and variability measures.
Improved catalytic activity in methanol electro-oxidation over the nickel form of aluminum-rich beta-SDS zeolite modified electrode (2015)

Nickel forms of aluminum-rich beta zeolite modified electrodes (Ni-beta-SDS/GC) exhibit high activities in methanol electro-oxidation compared with those of the conventional beta zeolites.
Mechanism of SHIP-Mediated Inhibition of Insulin- and Platelet-Derived Growth Factor-Stimulated Mitogen-Activated Protein Kinase Activity in 3T3-L1 Adipocytes (2004)

The Src homology 2-containing 5' inositolphosphatases (SHIP and SHIP2) dephosphorylate 3'-phosphorylated PtdIns on the 5' position, decreasing intracellular levels of PtdIns 3,4,5-P3. In the current study, we investigated the role of SHIP in insulin and platelet-derived growth factor (PDGF) signaling by expressing wild-type (WT) and catalytically inactive SHIPDeltaIP in 3T3-L1 adipocytes, utilizing adenoviral infection. Insulin and PDGF both stimulated tyrosine phosphorylation of SHIP-WT and of SHIPDeltaIP, and tyrosine phosphorylation of SHIP-associated proteins increased after ligand stimulation. Tyrosine-phosphorylated PDGFR, IR, and insulin receptor substrate-1 all immunoprecipitated with SHIP. Expression of WT and DeltaIP mutant SHIP did not affect tyrosine phosphorylation of either the insulin or the PDGF receptor, or the expression of insulin receptor substrate-1 and Shc proteins. Both SHIP-WT and SHIPDeltaIP blocked insulin and PDGF-induced MAPK and MAPK kinase phosphorylation as well as, GTP-bound Ras activity, suggesting that the catalytic activity of SHIP is not necessary for these effects. SHIP associated with Shc upon ligand stimulation, indicating that the SHIP-Shc association is phosphorylation dependent. This association was primarily between the SHIP-SH2 domain and the phosphorylated tyrosine residues of Shc because no association was observed when the 3YF-Shc mutant was coexpressed with SHIP. The Shc*Grb2 association was not compromised by SHIP expression, despite complete inhibition of the Ras/MAPK pathway. Interestingly, son-of-sevenless (SOS) protein normally found in Grb2 complexes was markedly reduced in SHIP expressing cells, whereas the displaced SOS was recovered when the post-Grb2-IP supernatants were blotted with anti-SOS antibody. Thus, SHIP competes son-of-sevenless (SOS) away from Shc-Grb2. In summary, 1) SHIP-WT and SHIPDeltaIP expression inhibit insulin and PDGF stimulated Ras, MAPK kinase, and MAPK activities; 2) SHIP associates with tyrosine phosphorylated Shc, and the proline-rich sequences in SHIP associate with Grb2 and titrate out SOS to form Shc*Grb2*SHIP complexes; and 3) dissociation of SOS from the Shc*Grb2 complex inhibits Ras GTP loading, leading to decreased signaling through the MAPK pathway.
Microstructural aspects of crystalline, melt-miscible polymer blends (1995)

In this paper, we describe our recent work on a series of miscible, model poly(ethylene oxide) (PEO) blends with both strongly and weakly-interacting amorphous polymers. Using primarily SAXS, we explore the relationship of intermolecular interactions and diluent Tg on blend microstructure. The relaxation behavior of these relatively well-defined materials will then be described, with particular emphasis on any contributions from the crystal-amorphous interphases. Finally, if time permits, a summary of our parallel study on compositional fluctuations in crystalline blends will be presented.
A role for the Dicer helicase domain in the processing of thermodynamically unstable hairpin RNAs (2008)

In humans a single species of the RNAseIII enzyme Dicer processes both microRNA precursors into miRNAs and long double-stranded RNAs into small interfering RNAs (siRNAs). An interesting but poorly understood domain of the mammalian Dicer protein is the N-terminal helicase-like domain that possesses a signature DExH motif. Cummins et al. created a human Dicer mutant cell line by inserting an AAV targeting cassette into the helicase domain of both Dicer alleles in HCT116 cells generating an in-frame 43-amino-acid insertion immediately adjacent to the DExH box. This insertion creates a Dicer mutant protein with defects in the processing of most, but not all, endogenous pre-miRNAs into mature miRNA. Using both biochemical and computational approaches, we provide evidence that the Dicer helicase mutant is sensitive to the thermodynamic properties of the stems in microRNAs and short-hairpin RNAs, with thermodynamically unstable stems resulting in poor processing and a reduction in the levels of functional mi/siRNAs. Paradoxically, this mutant exhibits enhanced processing efficiency and concomitant RNA interference when thermodynamically stable, long-hairpin RNAs are used. These results suggest an important function for the Dicer helicase domain in the processing of thermodynamically unstable hairpin structures.
Predictive Model for the Electrical Transport within Nanowire Networks (2018)

Thin networks of high aspect ratio conductive nanowires can combine high electrical conductivity with excellent optical transparency, which has led to a widespread use of nanowires in transparent electrodes, transistors, sensors, and flexible and stretchable conductors. Although the material and application aspects of conductive nanowire films have been thoroughly explored, there is still no model which can relate fundamental physical quantities, like wire resistance, contact resistance, and nanowire density, to the sheet resistance of the film. Here, we derive an analytical model for the electrical conduction within nanowire networks based on an analysis of the parallel resistor network. The model captures the transport characteristics and fits a wide range of experimental data, allowing for the determination of physical parameters and performance-limiting factors, in sharp contrast to the commonly employed percolation theory. The model thus constitutes a useful tool with predictive power for the evaluation and optimization of nanowire networks in various applications.
Minimizing Testing Overheads in Database Migration Lifecycle (2010)

As part of their information management lifecycle, organizations periodically face the important and inevitable task of migrating databases from one software and hardware platform to another. Apart from ensuring accuracy and consistency, information managers of such organizations need to minimize the costs associated with the database migration process. Some of the migration tasks such as identication of database
VAST contest dataset use in education (2009)

The IEEE Visual Analytics Science and Technology (VAST) Symposium has held a contest each year since its inception in 2006. These events are designed to provide visual analytics researchers and developers with analytic challenges similar to those encountered by professional information analysts. The VAST contest has had an extended life outside of the symposium, however, as materials are being used in universities and other educational settings, either to help teachers of visual analytics-related classes or for student projects. We describe how we develop VAST contest datasets that results in products that can be used in different settings and review some specific examples of the adoption of the VAST contest materials in the classroom. The examples are drawn from graduate and undergraduate courses at Virginia Tech and from the Visual Analytics ldquoSummer Camprdquo run by the National Visualization and Analytics Center in 2008. We finish with a brief discussion on evaluation metrics for education.
[Dmt1]N/OFQ(1‐13)‐NH2, a potent NOP/MOP receptor mixed agonist (2012)

i.t. nociceptin/orphanin FQ (N/OFQ) evokes antinociceptive effects in rodents. Studies in monkeys demonstrated that i.t. coapplication of N/OFQ and morphine elicits synergistic antinociceptive actions. Novel N/OFQ related peptides were synthesised in order to identify and characterize mixed NOP/MOP agonists. The following in vitro assays were used: Ca2+ mobilization in cells expressing hNOP or hMOP receptors and the chimeric protein Gαqi5, receptor and [35S]GTP&amp;#61543;S binding, guinea pig ileum bioassay. In vivo experiments were performed in mice and monkeys using the tail withdrawal assay. From Ca2+ mobilization studies [Dmt1]N/OFQ(1‐13)NH2 was selected as the most potent and least selective compound. The mixed NOP/MOP full agonist activity and high affinity of [Dmt1]N/OFQ(1‐13)NH2 was confirmed at recombinant receptors in receptor and [35S]GTP&amp;#61543;S binding studies, at rat spinal cord receptors in [35S]GTP&amp;#61543;S binding experiments, and in the guinea pig ileum. In vivo in mice and monkeys i.t. morphine and N/OFQ evoked similar antinociceptive effects. [Dmt1]N/OFQ(1‐13)NH2 was also able to elicit a robust antinociceptive action being more potent than N/OFQ (by 30 fold) and morphine (by 3 fold). These results demonstrate that [Dmt1]N/OFQ(1‐13)NH2 behaves as mixed NOP/MOP agonist and substantiate the proposal that such mixed ligands are worthy of development as spinal analgesics.
Multicomponent solid forms of antibiotic cephalexin towards improved chemical stability (2023)

Chemical stability of antibiotic cephalexin was improved by 2-fold in acidic medium using crystal engineering approach.
NAD precursors cycle between host tissues and the gut microbiome (2021)

Abstract Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor in both mammals and microbes. Here we use isotope tracing to investigate the precursors supporting NAD synthesis in the gut microbiome. We find that preferred dietary NAD precursors are absorbed in the proximal part of the gastrointestinal tract and not available to microbes in the distal gut. Instead, circulating host nicotinamide enters the gut lumen and supports gut microbiome NAD synthesis. In addition, the microbiome converts nicotinamide, originating from the host circulation, into nicotinic acid. Host tissues uptake and utilize this microbiome-derived nicotinic acid for NAD synthesis, maintaining circulating nicotinic acid levels even in the absence of dietary consumption. Moreover, the main route from oral nicotinamide riboside, a widely used nutraceutical, to host NAD is via conversion into nicotinic acid by the gut microbiome. Thus, NAD precursors cycle between the host and gut microbiome to maintain NAD homeostasis.
Optimized power combining technique to design a 20dB gain, 13.5dBm OCP1 60GHz power amplifier using 65nm CMOS technology (2012)

Millimeter-wave Distributed Active Transformer (DAT), baluns and zero degree 1-4 splitter have been optimized to design a 60 GHz parallel Power Amplifier (PA). The implementation is based on a thin digital 7 metal layers (1P7M) Back End of Line (BEOL) and Low Power (LP) transistors in 65 nm CMOS technology from STMicroelectronics. A lumped model based analysis is presented to compare pure voltage and mixed voltage and current combining techniques. Simulated and measured results are reported. At 61 GHz, the PA achieves a peak power gain of 20 dB with a 13.5 dBm 1dB-output compression point (OCP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1dB</sub> ), 15.6 dBm output power and a Power Added Efficiency (PAE) of 6.6% from a 1.2 V supply. To the author's knowledge, these results represent the highest linear output power and gain performances among PAs using the same technology.
Mobile Motion Gaming: Enabling a New Class of Phone-to-Phone Action Games on Commodity Phones (2013)

Mobile gaming is a big driver of app marketplaces. However, few mobile games deliver truly distinctive gameplay experiences for ad hoc collocated users. As an example of such an experience, consider a sword fight dual between two users facing each other where each user's phone simulates a sword. With phone in hand, the users' thrusts and blocks translate to attacks and counterattacks in the game. Such Phone-to-Phone Mobile Motion Games (MMG) represent interesting and novel gameplay for ad hoc users in the same location. One enabler for an MMG game like sword fight is continuous, accurate distance ranging. Existing ranging schemes cannot meet the stringent requirements of MMG games: speed, accuracy, and noise robustness. In this work, we design FAR, a new ranging scheme that can localize at 12 Hz with 2-cm median error while withstanding up to 0-dB noise, multipath, and Doppler effect issues. Our implementation runs on commodity smartphones and does not require any external infrastructure. Moreover, distance measurement accuracy is comparable to that of Kinect, a fixed-infrastructure motion capture system. Evaluation on users playing two prototype games indicate that FAR can fully support dynamic game motion in real time.
Photodynamic therapy for infections: Clinical applications (2011)

As yet clinical PDT for infections has been mainly in the field of dermatology using 5-aminolevulanic acid and in dentistry using phenothiazinium dyes. We expect more to see applications of PDT to more challenging infections using advanced antimicrobial photosensitizers targeted to microbial cells in the years to come.