gebhart/patrepeval huggingface dataset:
A Hybrid PNN-GMM classification scheme for speech emotion recognition (2008)

With the increasing demand for spoken language interfaces in human-computer interactions, automatic recognition of emotional states from human speeches has become of increasing importance. In this paper, we propose a novel hybrid scheme that combines the probabilistic neural network (PNN) and the Gaussian mixture model (GMM) for identifying emotions from speech signals. In order to handle mismatches more effectively, the universal background model (UBM) is incorporated into the GMM, and the resultant model is denoted as UBM-GMM. In the hybrid scheme, the strengths of the PNN and the UBM-GMM are combined through a novel conditional-probability based fusion algorithm. Experimental results show that the proposed scheme is able to achieve higher recognition accuracy than that obtained by using PNN or UBM-GMM alone.
Effects of proportion of pigs removed from a group and subsequent floor space on growth performance of finishing pigs1 (2005)

The effects of the proportion of pigs removed from an established group and subsequent floor space on growth performance during the final 19 d of the finishing period were evaluated using 28 pens of mixed-sex crossbred pigs (mean initial BW = 113.4 +/- 0.57 kg; n = 1,456; approximately 52 pigs per pen). A randomized block design was used with four pig-removal treatments: 1) 0% of pigs removed [Control], 2) approximately 25% of pigs removed, 3) approximately 50% of pigs removed, and 4) approximately 50% of pigs removed and floor and feeder spaces/pig decreased to equal those of Control. A block consisted of four pens with the same number of pigs and sex ratio per pen and with similar initial BW. Pens within blocks were randomly allocated to treatment, and the heaviest animals were removed from Treatments 2, 3, and 4 at the start of the study. Group size and floor space/pig for Treatments 1, 2, 3, and 4 were 52 and 0.65 m(2), 39 and 0.87 m(2), 26 and 1.30 m(2), and 26 and 0.65 m(2), respectively. Each pen contained a six-place feeder that provided 212 cm of total trough space; however, only three-places were accessible to pigs on Treatment 4. Compared with Controls, removing 25 or 50% of pigs resulted in increased (P < 0.001) ADG by 20.6 and 21.0%, ADFI by 10.8 and 7.9%, and G:F by 7.7 and 14.3%, respectively. Average daily gain by pigs on Treatment 4 (50% removal rate and decreased floor and feeder spaces) was greater (P < 0.05) than that of the Controls, but lower (P < 0.05) than that of Treatment 3 pigs (50% removal rate, no adjustment in floor or feeder spaces). No differences were observed among treatments for either morbidity or mortality. These results indicate that removing 25 or 50% of the heaviest pigs from groups of finishing pigs increased growth rate of the remaining pigs, and that the improved performance was only partly due to increased floor and feeder spaces.
Design of a Highly-Efficient Light Guide Plate for the Edge Lighting Backlight Module (2007)

This study develops a highly-efficient light-guide plate for edge lighting backlight module that has no optical films. The light guide plate is designed to control the angle of the incident rays to the top surface from light source, to get the highest uniformity of intensity for thin edge lighting backlight system applications. The micro-prisms of pyramidal shape on the top surface can highly-efficient collimate with the light rays. Another micro-prism of v-cut shape on the bottom surface can reflect the incident light into the front direction and mixing the rays in the lightguide plate with the high uniformity. A novel design concept of the v-cut is the regular density varies of the cut in the LGP. The modeling simulation program, employing a Monte Carlo method based on TracePro software, has optimized the shape of the pyramidal micro-prisms on the top surface and the density distribution condition of the v-cut micro-prisms on the bottom surface, also the multiple scattering characteristics. The two types of the micro-prisms at the top and bottom surface can be highly recommended for the uniformity of the brightness via the optimal design process. Future work is warranted on improving the optical efficiency by using light-emitting diodes as a light source. The backlight module will allow us to increase the optical efficiency and to lower the total cost in portable LCD applications. The study confirms that a uniformity of brightness can be achieved without using any optical films, resulting in a high uniformity of 84%.
Abstract 17758: Anti-Tachycardia Pacing Has Minimal Impact on Daily Activities Compared to Shocks (2013)

Introduction: Implantable Cardioverter Defibrillators (ICDs) can deliver either anti-tachycardia pacing (ATP) or shocks to terminate life-threatening ventricular arrhythmias. Multiple studies have shown the negative psychological consequences of multiple shocks as measured through quality of life (QOL) questionnaires. Current ICDs measure and store minutes of daily activity which we hypothesized may be sensitive to ICD therapies and, thus, a possible surrogate for QOL. Our goal was to compare the impact of ATP and shocks on patient (pt) activity.

Methods: We performed a retrospective analysis using 900 pts from the EMPIRIC study to determine the change in weekly hours of activity from pre (baseline) to post ICD therapy for shocks and ATP. Patients with an ICD therapy were separated into two groups based on their initial therapies (shock with or without ATP, ATP-only). We calculated the change in activity from cumulative activity 1 week pre-therapy to 1 week post-therapy. The activity change was compared for one, few (2-4) and many (≥5) therapies.

Results: There were 67 pts with shocks (1 - 13 / pt) and 99 pts with ATP-only (1 to 45 sequences / pt). Activity changed by a median -0.5 weekly hours (range: -41 to 14 hours) for pts with at least 1 shock compared to a median change of +0.1 weekly hours (range: -17 to 14 hours) for patients with ATP-only. Patients receiving ATP-only had a non-significant change in activity (figure). Patients receiving at least 1 shock had a significant activity change for few (p=0.02) and many therapies (p=0.01). Increasing the number of ATP sequences did not significantly impact pt activity (p=0.77). Increasing the number of shocks significantly decreased pt activity (p<0.001).

Conclusions: Patients who received ATP-only therapies had minimal impact on activity while shocked pts had temporal declines in activity. These findings suggest that patient activity may be sensitive to ICD therapies. Further analysis with a larger database is required.

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Robust Watermarking of Point-Sampled Geometry (2004)

We present a new scheme for digital watermarking ofpoint-sampled geometry based on spectral analysis. Byextending existing algorithms designed for polygonal datato unstructured point clouds, our method is particularlysuited for scanned models, where the watermark can bedirectly embedded in the raw data obtained from the 3Dacquisition device. To handle large data sets efficiently, weapply a fast hierarchical clustering algorithm that partitionsthe model into a set of patches. Each patch is mappedinto the space of eigenfunctions of an approximate Laplacianoperator to obtain a decomposition of the patch surfaceinto discrete frequency bands. The watermark is thenembedded into the low frequency components to minimizevisual artifacts in the model geometry. During extraction,the target model is resampled at optimal resolution usingan MLS projection. After extracting a watermark from thismodel, the corresponding bit stream is analyzed using statisticalmethods based on correlation. We have applied ourmethod to a number of point-sampled models of differentgeometric and topological complexity. These experimentsshow that our watermarking scheme is robust againstnumerous attacks, including low-pass filtering, resampling,affine transformations, cropping, additive randomnoise, and combinations of the above.
Proceedings of the 2nd Workshop on Computational Models of Social Interactions: Human-Computer-Media Communication (2015)

It is our great pleasure to welcome you to the 2nd Workshop on Computational Models of Social Interaction: Human-Computer-Media Communication, HCMC'15. This year's workshop continues its tradition of being the premier forum for presentation of research results and experience reports on leading edge issues of social interactions ranging from dyadic to multi-personal, including models, systems, applications, and theory spanning multiple -- pertinent disciplines such as multimedia content analysis, social network analytics, behavior science and neuro-science among others. The mission of the symposium is to share novel approaches to social interaction modeling and systems that fulfill the needs of interactive applications and environments and identify new directions for future research and development. HCMC gives researchers and practitioners a unique opportunity to share their perspectives with others interested in the various aspects of computational models of social interaction. We also encourage attendees to attend the keynote and invited talk presentations. These valuable and insightful talks can and will guide us to a better understanding of the future of Human- Computer-Media Communication: Lexing Xie "Can a video be promoted? a generative model for social media popularity"Alberto Del Bimbo "Natural Interaction Metaphors for Personalized Multimedia Museum Experiences"Ajay Divakaran "Human Social Interaction Sensing and Modeling"Vivek Singh "Sensing and Shaping Human Behavior using Multimodal Signals"Mohan Kankanhalli "Social Interactions and Presentation Analytics"
A population pharmacokinetic/pharmacodynamic model for the mobilization of progenitor cells by AMD3100 (2005)

Background AMD3100 is a small molecule CXCR4 antagonist that has been shown to induce the mobilization of hematopoietic stem cells (CD34+) from the bone marrow to peripheral blood. The purpose of this study was to characterize the exposure-response (ER) relationship of AMD3100 in mobilizing CD34+ cells. Methods AMD3100 concentrations and CD34+ cell counts obtained from 29 healthy subjects in a single dose, intensively sampled PK-PD study were analyzed using nonlinear mixed effects regression with the software NONMEM. FOCE with interaction was the estimation method and simultaneous PK-PD fitting was adopted. Results The PK of AMD3100 was described by a two compartment model with first order absorption. The population estimates for clearance (CL) and central volume of distribution (V) (± SE) were 5.17 L/hr (0.49) and 16.9 L (3.79) respectively. CD34+ cell mobilization was best described by an indirect effect model that stimulates the entry process of CD34+ from the bone marrow to peripheral blood in the form of sigmoid Emax model. The population estimates of Emax, EC50 and equilibration time (± SE) were 12.6 (4.89), 53.6 mcg/L (11.9) and 5.37 hours (1.31) respectively. Conclusions The ER relationship of AMD3100 in mobilizing CD34+ cells following subcutaneous administration was adequately characterized. Experimentation in patient populations is required to characterize the ER relationship further. Clinical Pharmacology & Therapeutics (2005) 77, P92–P92; doi: 10.1016/j.clpt.2004.12.245
Polarized-x-ray-absorption studies of graphite intercalated-bromine compounds (1986)

Details of both results and data analysis are given in the case of our polarized-x-ray-absorption experiments, using synchrotron radiation, on highly oriented pyrolytic graphite (HOPG)--based and graphite-fiber-based residual-bromine intercalation compounds. The effective angle which nearest-neighbor Br pairs make with crystallite graphite planes in some of these compounds, which was stated to be \ensuremath{\sim}20\ifmmode^\circ\else\textdegree\fi{} in an earlier article, is shown to be 16?(de\ifmmode\pm\else\textpm\fi{}4?(de---both Br-Br extended x-ray-absorption fine structure (EXAFS) and white-line features of the data are the basis of this result. We have also found that, whereas spherical averages of the areas under white-line spectra are independent of the choice of the material among all samples studied (including ${\mathrm{Br}}_{2}$ vapor), differences in similarly spherically averaged Br-Br EXAFS amplitudes are evident, especially between ${\mathrm{Br}}_{2}$ vapor and Br-graphite samples. We show that the latter differences which correspond to a coordination number less than one in Br-graphite are not due to either Gaussian or non-Gaussian (up to ${k}^{4}$ terms) Debye-Waller effects. In addition, we discuss the extraction of Br-C EXAFS and present results of model calculations of Br-C EXAFS, where several different structural models for the Br sites are considered. We also discuss thermal effects and their relation to known Br sublattice phase-transition behavior, based on our measurements at room temperature, 360 K, and 400 K.
Immersion defect reduction, part II: the formation mechanism and reduction of patterned defects (2007)

193-nm immersion lithography is the only choice for the 45-nm logical node at 120-nm half pitch and extendable to 32- and 22-nm nodes. The defect problem is one of the critical issues in immersion technology. In this paper, we provided a methodology to trace the defect source from optical microscope images to its SEM counterparts after exposure. An optimized exposure routing was also proposed to reduce printing defects. The average defect count was reduced from 19.7 to 4.8 ea/wafer.
Microchip-based enzyme-linked immunosorbent assay (microELISA) system with thermal lens detection (2004)

A microchip-based enzyme-linked immunosorbent assay (microELISA) system was developed and interferon-gamma was successfully determined. The system was composed of a microchip with a Y-shaped microchannel and a dam structure, polystyrene microbeads, and a thermal lens microscope (TLM). All reactions required for the immunoassay were done in the microchannel by successive introduction of a sample and regents. The enzyme reaction product, in a liquid phase, was detected downstream in the channel using the TLM as substrate solution was injected. The antigen-antibody reaction time was shortened by the microchip integration. The limit of the determination was improved by adopting the enzyme label. Moreover, detection procedures were greatly simplified and required time for the detection was significantly cut. The system has good potential to be developed as a small and automated high throughput analyzer.
A sub-gigahertz UWB positioning system with automatic network configuration (2011)

This paper presents a full 2-D positioning system based on sub-gigahertz ultra-wideband (UWB) radio, which does not rely on a pre-existing infrastructure and is intended for emergency scenario. Relative positions of up to eight anchors and/or mobile nodes are updated four times per second. Each beacon includes an UWB emitter, a receiver based on 1-bit quantization, baseband processing and a 433 MHz ISM radio for data exchange and synchronization. Positions are calculated on a computer in real-time from the time-of-arrival (TOA) matrix. The system also achieves medium range capability (85 m) thanks to coherent integration of very long sequences of pulses (64 k pulses). Measurements have shown a 2-D positioning accuracy of 25 cm, and the system has been successfully tested in an underground parking with coverage of 1000 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Supplementary Figure 2 from Epigenetic Potentiation of NY-ESO-1 Vaccine Therapy in Human Ovarian Cancer (2023)

&lt;p&gt;PDF file - 54K, Figure S2. Recognition of naturally processed NY-ESO-1 antigen by NY-ESO-1 specific T cells, pre- and post-therapy.&lt;/p&gt;
Detection and Identification of Ehrlichia Species in Blood by Use of PCR and Electrospray Ionization Mass Spectrometry (2009)

Rapid detection and identification of Ehrlichia species improves clinical outcome for patients suspected of ehrlichiosis. We describe an assay that employs multilocus PCR and electrospray ionization mass spectrometry (PCR/ESI-MS) to detect and identify Ehrlichia species directly from blood specimens. The results were compared to those of a colorimetric microtiter PCR enzyme immunoassay (PCR-EIA) used as a diagnostic assay. Among 213 whole-blood samples collected from patients who were clinically suspected of ehrlichiosis from 1 May to 1 August 2008 at Vanderbilt University Hospital, 40 were positive for an Ehrlichia species by PCR/ESI-MS, giving a positive rate of 18.8%. In comparison to the PCR-EIA, PCR/ESI-MS possessed a sensitivity, a specificity, and positive and negative predictive values of 95.0%, 98.8%, 95.0%, and 98.8%, respectively. The 38 specimens that were positive for Ehrlichia by both PCR/ESI-MS and the PCR-EIA were further characterized to the species level, with 100% agreement between the two assays. In addition, Rickettsia rickettsii was detected by PCR/ESI-MS from four specimens that were confirmed retrospectively by serology and PCR-EIA. In three specimens, the PCR/ESI-MS assay identified Pseudomonas aeruginosa, Neisseria meningitidis, and Staphylococcus aureus; these were confirmed by culture and/or clinical diagnosis as being clinically relevant. From specimen processing to result reporting, the PCR/ESI-MS assay can be completed within 6 h, providing another laboratory tool for the diagnosis of ehrlichiosis. Moreover, this system may provide rapid detection and identification of additional pathogens directly from blood specimens.
Data from <i>Paired Box 5</i> Methylation Detection by Droplet Digital PCR for Ultra-Sensitive Deep Surgical Margins Analysis of Head and Neck Squamous Cell Carcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;Molecular deep surgical margin analysis has been shown to predict locoregional recurrences of head and neck squamous cell carcinoma (HNSCC). To improve the accuracy and versatility of the analysis, we used a highly tumor-specific methylation marker and highly sensitive detection technology to test DNA from surgical margins. Histologically cancer-negative deep surgical margin samples were prospectively collected from 82 eligible HNSCC surgeries by an imprinting procedure (&lt;i&gt;n&lt;/i&gt; = 75) and primary tissue collection (&lt;i&gt;n&lt;/i&gt; = 70). Bisulfite-treated DNA from each sample was analyzed by both conventional quantitative methylation-specific PCR (QMSP) and QMSP by droplet digital PCR (ddQMSP) targeting &lt;i&gt;Paired box 5&lt;/i&gt; (&lt;i&gt;PAX5&lt;/i&gt;) gene promoter methylation. The association between the presence of &lt;i&gt;PAX5&lt;/i&gt; methylation and locoregional recurrence-free survival (LRFS) was evaluated. &lt;i&gt;PAX5&lt;/i&gt; methylation was found in 68.0% (51 of 75) of tumors in the imprint samples and 71.4% (50 of 70) in the primary tissue samples. Among cases that did not have postoperative radiation (&lt;i&gt;n&lt;/i&gt; = 31 in imprint samples, &lt;i&gt;n&lt;/i&gt; = 29 in tissue samples), both conventional QMSP and ddQMSP revealed that &lt;i&gt;PAX5&lt;/i&gt; methylation–positive margins was significantly associated with poor LRFS by univariate analysis. In particular, ddQMSP increased detection of the &lt;i&gt;PAX5&lt;/i&gt; marker from 29% to 71% in the nonradiated imprint cases. Also, &lt;i&gt;PAX5&lt;/i&gt; methylated imprint margins were an excellent predictor of poor LRFS [HR, 3.89; 95% confidence interval (CI), 1.19–17.52; &lt;i&gt;P&lt;/i&gt; = 0.023] by multivariate analysis. &lt;i&gt;PAX5&lt;/i&gt; methylation appears to be an excellent tumor-specific marker for molecular deep surgical margin analysis of HNSCC. Moreover, the ddQMSP assay displays increased sensitivity for methylation marker detection. &lt;i&gt;Cancer Prev Res; 8(11); 1017–26. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Abstract 181: BET Bromodomain Inhibition Suppresses Endothelial Inflammation and Atherosclerosis (2013)

Introduction The BET bromodomain-containing family of proteins (BRD2, BRD3, BRD4) are epigenetic readers that coactivate transcription. Recent evidence indicates that BETs promote carcinogenesis and inflammation in sepsis, while BET bromodomain inhibitors are promising anti-cancer therapies. However, the role of chromatin remodeling in atherosclerosis in general and through BETs in particular remains unknown. Hypothesis We hypothesized that BET bromodomain-containing proteins coactivate proinflammatory responses in the vasculature with functional effects that promote atherogenesis. Methods and Results BET bromodomain inhibition, achieved with the highly selective, small-molecule inhibitor JQ1 significantly reduced early atherosclerosis (12 weeks) in cholesterol-fed, LDL receptor-null mice. In pursuing mechanisms for this effect, we identified BET protein expression in mouse and human endothelial cells (ECs) as well as endothelium from human atherosclerotic plaque. Treating human umbilical vein endothelial cells (HUVECs) with either JQ1 or siRNA to BRD2 or BRD4 potently suppresses TNFα-induced expression of adhesion molecules (SELE, VCAM1) and chemokines (CCL2, CXCL8). In chromatin immunoprecipation studies, TNFα stimulation of ECs recruited BETs to adhesion molecule and chemokine promoters coincident with RNA polymerase II and cyclin T1 localization, without altering NF-κB recruitment. In functional studies, JQ1 suppressed 1) monocyte adhesion to TNFα-activated HUVECs, 2) leukocyte rolling on cremaster post-capillary venules (intravital microscopy); 3) leukocyte transmigration (parallel-plate flow chamber); and 4) monocyte recruitment in thioglycolate-induced peritonitis in vivo . Conclusions BET bromodomain-containing proteins are novel determinants of pro-inflammatory transcription in the endothelium. Targeting chromatin by BET bromodomain inhibition may be a therapeutic strategy to limit atherosclerosis and other disorders involving endothelial inflammation.
Hydrophobicity Profiles for Protein Sequence Analysis (1995)

Hydrophobic interactions are a major force in protein folding and numerous hydropathy scales have been developed to quantify the relative hydrophobicity of the amino acids. Hydropathy profiles can be used to examine the surface features of proteins in order to generate hypotheses that can be confirmed experimentally. This unit describes the application of hydrophobicity plots to typical problems and provides suggested uses for a few selected scales.
Supplementary Materials from Functional Identification of Cancer-Specific Methylation of <i>CDO1</i>, <i>HOXA9</i>, and <i>TAC1</i> for the Diagnosis of Lung Cancer (2023)

&lt;p&gt;PDF file - 108KB&lt;/p&gt;
Determination of total and unbound docetaxel in plasma by ultrafiltration and UPLC-MS/MS: application to pharmacokinetic studies (2017)

A sensitive and specific liquid chromatographic/tandem mass spectrometric (LC-MS/MS) method was developed and validated for quantifying total and unbound docetaxel drug concentrations in plasma. Calibration curves for unbound and total docetaxel were linear over the respective ranges of 0.108~10.8 and 0.54~216 ng/mL. The intra- and interday assay accuracy and precision did not exceed 15%. The methods were validated to show the standard range linearity, sensitivity, selectivity, accuracy, precision, and stability of docetaxel in the matrices tested. In addition, this method is fast and simple with a short run time of 4.5 min and a small plasma sample volume (500 µL). The validated method was successfully applied to a pharmacokinetic study of a docetaxel micelle formulation in rat plasma after intravenous administration at a dose of 10 mg/kg. Docetaxel micelles slowly released their drug payload, and protein-bound, unbound, and micellar drug pools existed simultaneously. These various forms in plasma pools were also measured in the study. We confirmed that most of the docetaxel in plasma was micelle-associated (96.52% at 24 h and 83.14% at 72 h) after micellar docetaxel administration, as a result of sequestration of the drug in long-circulating micelles.