gebhart/patrepeval huggingface dataset:
Hepatectomy outcomes in patients with hepatitis C virus-related hepatocellular carcinoma with or without cirrhosis (2022)

The cirrhotic group showed poor prognosis due to poor liver function after LR compared to the non-cirrhotic group, but this was not sustained in multivariate analysis. The factors influencing HCC recurrence and death were different in the cirrhotic and non-cirrhotic groups.
Sequence Tolerance of a Highly Stable Single Domain Antibody: Comparison of Computational and Experimental Profiles (2016)

Abstract : The sequence fitness of a single-domain antibody with unusually high thermal stability is explored by a combined computational and experimental study. Starting with the crystallographic structure, RosettaBackrub simulations were applied to model sequence-structure tolerance profiles and identify key substitution sites. Experimental site-directed mutagenesis was used to produce a panel of mutants and their melting temperatures were determined by thermal denaturation. The results reveal an excess stability margin of approximately 12 deg.C, a value taken from a decrease in the melting temperature of an electrostatic charge reversal substitution in the CRD3 without a deleterious effect on the binding affinity to the antigen target. Tolerance for disruption of antigen recognition without loss in thermal stability was demonstrated by the introduction of a proline in place of a tyrosine in the CDR2, producing a mutant that eliminated binding. To reconcile the differences between the modeled energies and their relationship to the observed experimental changes in melting temperatures, an approximation was developed by combining a statistical potential with a linearly scaled implicit solvent model to calculate the net contribution from a two-state model of folded and unfolded conformations. The derived computational model improves prediction accuracy and should prove applicable to other designs of antibodies.
Hardmetals Based on Niobium Carbide (NBC) Versus Casted NBC Bearing MMCS (2015)

This paper indicates that the tribological behavior under dry sliding of a Fe3Al-niobium carbide (NbC) composite prepared by pyrometallurgical synthesis was compared to NbC-based hard metals bonded by cobalt or Fe3Al. The dry sliding wear resistance (0,1-7/10 m/s) of the present Fe3Al-NbC with ∼60% NbC was close to those known of NbC-based hard metals. No grain pull-outs or fragmentations of the NbC grains were seen in the wear tracks, as a metallurgical interphase was formed between matrix and NbC grains.
Hypoxic Radiosensitizers: Substituted Styryl Derivatives (1994)

A number of novel styryl epoxides, N-substituted-styryl-ethanolamines, N-mono and N,N'-bis-(2-hydroxyethyl)-cinnamamides--analogues to the known radiosensitizers RSU-1069, pimonidazole and etanidazole--display selective hypoxic radiosensitizing activity. The styryl group, especially when substituted by electron withdrawing groups, was found to be bioisosteric to the nitroimidazolyl functionality. The most active derivative 2-(2'-nitrophenyl)ethen-1-yl-oxirane 8a displayed a sensitizer enhancement ratio (SER) of 5 relative to misonidazole.
Statistical corner conditions of interconnect delay (corner LPE specifications) (2006)

Timing closure in LSI design becomes more and more difficult. But the conventional interconnect RC extraction method have over-margins caused by its corner conditions settings. In this paper, statistical corner conditions using the independence of variations between process parameters and between interconnect layers are proposed. As a result, the fast-to-slow guardband decreases by half in average, compared to the conventional method. The proposed method is ready for implementation to LPE tools.
Lack of long‐term clinical benefit of thrombus aspiration during primary percutaneous coronary intervention with paclitaxel‐eluting stents or bare‐metal stents: Post‐hoc analysis of the PASSION‐trial (2011)

In this post-hoc analysis of the PASSION trial, TA in adjunct to PPCI did not affect rates of major adverse cardiac events at 2 years follow-up, as compared with conventional PPCI.
Resonance-Free Light Recycling (2017)

The inability to efficiently tune the optical properties of waveguiding structures has been one of the major hurdles for the future scalability of integrated photonic systems. In silicon photonics, although dynamic tuning has been achieved with various mechanisms, even the most effective thermo-optic effect offers a refractive index change of only $1.86 \times 10^{-4} K^{-1}$. To enhance this small change, light recycling based on resonators has been employed in order to realize efficient modulators, phase shifters, and optical switches. However, the resonant enhancement comes at a great cost of optical bandwidth, fabrication tolerance and system scalability. Here we demonstrate a scalable light recycling approach based on spatial-mode multiplexing. Our approach offers a fabrication tolerance of ${\pm}$ 15 nm, in stark contrast to the non-scalable subnanometer tolerance in typical silicon resonators. We experimentally demonstrate light recycling up to 7 passes with an optical bandwidth greater than 100 nm. We realize power-efficient thermo-optic phase shifters that require only 1.7 mW per $π$, representing more than an 8-fold reduction in the power consumption.
High speed optoelectronic InP/InGaAs logic pixel (2002)

We describe InP/InGaAs optoelectronic smart pixels consisting of monolithically integrated p-i-n photodiodes, heterojunction bipolar transistor (HBT) receivers and transmitters, and surface-bonded folded-cavity surface emitting lasers (FCSELs). A minimum switching energy of 6 fJ, a maximum pixel bandwidth of 800 MHz, and a optoelectronic gain of 3 are achieved. These performance characteristics are competitive or superior to those of all-electronic interconnects.
Recognition of distorted patterns by invariance kernels (2002)

A method for the recognition of deformed patterns is presented. It is is shown that for planar deformations generated by Lie transformation groups, there exist kernels such that the associated integral transforms are invariant under the deformations. Many examples of deformations and the corresponding kernels are given. It is possible to extend the results to higher dimensions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Lattice‐based memory polynomial predistorter for wideband radio frequency power amplifiers (2014)

This study addresses the ill‐conditioning problem of the memory polynomial (MP) model with application to the predistortion of highly non‐linear power amplifiers with memory effects. A resource‐efficient lattice‐based MP structure built using the cascade of a MP generator and a lattice predictor is proposed to overcome the ill‐conditioning of the MP's data matrix. The proposed model performances are benchmarked against those of the MP model as well as the orthogonal MP model. The experimental results demonstrate the suitability of the proposed predistorter as it achieves similar performance in the time and the frequency domains compared to the MP counterpart while alleviating its ill‐conditioning problem.
Rhodium‐Catalyzed Asymmetric Allenylation of Sulfonylimines and Application to the Stereospecific Allylic Allenylation (2016)

Abstract The rhodium‐catalyzed asymmetric allenylation of sulfonylimines is disclosed providing silyl homoallenylamide products in up to 99:1 er . Through subsequent activation of the C−N bond of the silyl homoallenyl sulfonamide, palladium‐catalyzed stereospecific allylic allenylation could be achieved giving C−C bond formation with high chirality transfer. The synthetic utility of both the silyl homoallenyl sulfonamides and the silyl homoallenyl malonates as bis(nucleophiles) is demonstrated. magnified image
Data reuse analysis technique for software-controlled memory hierarchies (2004)

In multimedia and other streaming applications a significant portion of energy is spent on data transfers. Exploiting data reuse opportunities in the application, we can reduce this energy by making copies of frequently used data in a small local memory and replacing speed and power inefficient transfers from main off-chip memory by more efficient local data transfers. In this paper we present an automated approach for analyzing these opportunities in a program that allows modification of the program to use custom scratch pad memory configurations comprising a hierarchical set of buffers for local storage of frequently reused data. Using our approach we are able to reduce energy consumption of the memory subsystem when using a scratch pad memory by a factor of two on average compare to a cache of the same size.
Optical and electrical properties of Al1−xInxN films grown by plasma source molecular-beam epitaxy (2001)

Epitaxial Al1−xInxN thin films with 0⩽x⩽1 have been grown by plasma source molecular beam epitaxy on sapphire (0001) substrates at a low temperature of 375 °C. Both reflection high-energy electron diffraction and x-ray diffraction measurements confirm the c-plane growth with the following epitaxial relations: nitride [0001] ∥ sapphire [0001] and nitride 〈011̄0〉 ∥ sapphire 〈21̄1̄0〉. However, the degree of crystalline mosaicity and the compositional fluctuation increase with increasing x. The observed direct energy band gap, determined using optical transmission and reflection measurements show relatively less bowing compared to some earlier studies. Electrical resistivity and Hall effect measurements show n-type electrical conductivity in these alloys with carrier concentrations n⩾1019 cm−3 for In-rich alloys and n⩽1010 cm−3 for Al-rich alloys.
The latest developments of high-gain Si microchannel plates (2003)

We present our latest results in the development of Silicon micromachined microchannel plates, which open completely new possibilities in the detector technologies. For the first time Z-stacks of Si microchannel plates with pore bias of 5-8 degrees were tested in a high gain photon counting imaging detector without any post-amplification stage with conventional glass MCP's. The gain of Z-stacks of Si (40:1 L/D, 6 &#956;m pores on 8 &#956;m centers, 18-25 mm in diameter) MCP's was found to be as high as ~10<sup>6</sup> with peaked pulse height distribution. The full-field illumination images appeared to be quite uniform, with relatively small (~±10%) gain variation. Quantum efficiency of opaque diamond photocathode deposited on Si MCP was measured in reflection mode and compared with the performance of flat-substrate diamond photocathodes. We also present the results of our study of long-term gain stability of Si MCP's: variation of Si MCP gain as a function of extracted charge was investigated.
A stereospecific total synthesis of aklavinone (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA stereospecific total synthesis of aklavinoneAndrew S. Kende and James P. RizziCite this: J. Am. Chem. Soc. 1981, 103, 14, 4247–4248Publication Date (Print):July 1, 1981Publication History Published online1 May 2002Published inissue 1 July 1981https://pubs.acs.org/doi/10.1021/ja00404a046https://doi.org/10.1021/ja00404a046research-articleACS PublicationsRequest reuse permissionsArticle Views493Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bones about skeletons (1996)

The final word (at least for the moment) on biomimetic inorganic chemistry is given to Geoffrey Ozin, who stresses the importance of the work of Harting, arguing that Harting's original idea of assembling inorganic precursors in the presence of organics is still the common thread that runs through all modern syntheses of inorganic materials inspired by biological construction principles.
Data from High-Throughput Detection of Clinically Relevant Mutations in Archived Tumor Samples by Multiplexed PCR and Next-Generation Sequencing (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Tailoring cancer treatment to tumor molecular characteristics promises to make personalized medicine a reality. However, reliable genetic profiling of archived clinical specimens has been hindered by limited sensitivity and high false-positive rates. Here, we describe a novel methodology, MMP-seq, which enables sensitive and specific high-throughput, high-content genetic profiling in archived clinical samples.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We first validated the technical performance of MMP-seq in 66 cancer cell lines and a Latin square cross-dilution of known somatic mutations. We next characterized the performance of MMP-seq in 17 formalin-fixed paraffin-embedded (FFPE) clinical samples using matched fresh-frozen tissue from the same tumors as benchmarks. To demonstrate the potential clinical utility of our methodology, we profiled FFPE tumor samples from 73 patients with endometrial cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; We demonstrated that MMP-seq enabled rapid and simultaneous profiling of a panel of 88 cancer genes in 48 samples, and detected variants at frequencies as low as 0.4%. We identified DNA degradation and deamination as the main error sources and developed practical and robust strategies for mitigating these issues, and dramatically reduced the false-positive rate. Applying MMP-seq to a cohort of endometrial tumor samples identified extensive, potentially actionable alterations in the PI3K (phosphoinositide 3-kinase) and RAS pathways, including novel PIK3R1 hotspot mutations that may disrupt negative regulation of PIK3CA.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; MMP-seq provides a robust solution for comprehensive, reliable, and high-throughput genetic profiling of clinical tumor samples, paving the way for the incorporation of genomic-based testing into clinical investigation and practice. &lt;i&gt;Clin Cancer Res; 20(8); 2080–91. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
New insight on the subchondral bone and cartilage functional unit: Bone mineral density and cartilage thickness are spatially correlated in non-osteoarthritic femoral condyles (2020)

The positive spatial relationship between the locations of thickest CTh and densest sBMD supports the idea of a functional cartilage/subchondral bone unit with morphological coupling conditioned by the individual loading pattern.
Monoclonal antibody-defined immunoregulatory cells in multiple sclerosis cerebrospinal fluid. (1982)

To determine if previously reported peripheral blood suppressor cell defects are also found in the central nervous system (CNS) of patients with multiple sclerosis (MS), we studied cerebrospinal fluid (CSF) and peripheral blood lymphocytes from 40 MS patients and 15 patients with other neurological diseases. With an indirect immunofluorescence technique using the OKT series of monoclonal antibodies (OKT4, marking helper/inducer cells, OKT5 and OKT8 marking suppressor/cytotoxic cells, and OKT3 marking all peripheral T cells) we found that MS patients tested in the first 2 wk of exacerbation had invariably diminished CSF suppressor/cytotoxic cells, which was followed by an elevation of these cells in the 3rd wk of exacerbation. Repeat studies of three patients showed that perturbations of CSF suppressor/cytotoxic cells were dependent on clinical status. These observations add to the accumulating data that suggest altered immunity in the pathogenesis of MS.
Pinhole Formation in Printed Electronic Traces Fabricated via Molten Metal Droplet Jetting (2021)

The fabrication of printed electronic devices via molten metal droplet jetting has enormous potential in flexible electronic device applications due to the extremely high electrical conductivity and excellent substrate adhesion of printed features. However, large pinholes (which could be detrimental to the feature performance) have been experimentally observed when molten metal droplets of aluminum 4043 alloy are deposited and solidified on a polyimide (PI) substrate. In this study, we have shown that subjecting the polymer substrate to elevated temperature during droplet deposition considerably reduces the number and size of pinholes. The formation mechanism behind the large pinholes is interpreted as the release of the adsorbed/absorbed moisture from the polymer substrate into the solidifying droplet due to the rapid rise in temperature of the substrate upon droplet impact. Through numerical modelling, we have shown that the temperature of the polyimide substrate underneath the deposited droplet exceeds the boiling point of water while the metal droplet is still in liquid state, showing the possibility of water vapor escaping from the substrate and causing pinholes in the solidifying metal.
Broadening beamwidth of E-plane radiation pattern of a dipole antenna with loaded monopole elements (2004)

Dipole antennas are widely used as the radiating elements of phased array antennas for communications and radar systems. The E-plane radiation pattern of a dipole antenna placed above a ground plane generally has a narrower beamwidth than that of the H-plane. Therefore, it is strongly desired to broaden the E-plane radiation pattern to achieve wide-scanning while keeping gain. A method to broaden the E-plane radiation pattern of a single dipole antenna over a ground plane is proposed, where two parasitic monopole elements with reactive impedance loads are placed in the vicinity of the driving dipole element. Numerical simulations using the EMF method and the method of moments (MoM) are shown to obtain an appropriate value of the reactance and the parameters of the antenna geometry for a broad beamwidth. Experimental results are also shown to demonstrate the broad beamwidth.
Design of Short-Term Forecasting Model of Distributed Generation Power for Solar Power Generation (2015)

Background/Objectives: For efficient PhotoVoltaic (PV) power generation, computing and information technologies are increasingly used in irradiance forecasting and correction. Methods/Statistical Analysis: Today the majority of PV modules are used for grid-connected power generation, so solar generation forecasting that predicts available PV output ahead is essential for integrating PV resources into electricity grids. This paper proposes a short-term solar power forecasting system that employs Neural Network (NN) models to forecast irradiance and PV power. Results: The proposed system uses the weather observations of a ground weather station, the medium-term weather forecasts of a physical model, and the short-term weather forecasts of the Weather Research and Forecasting (WRF) model as input. To increase prediction accuracy, the proposed system performs forecast corrections and determines the correction coefficients based on the characteristics and temperature of PV modules. The proposed system also analyzes the inclination angle of PV modules to predict PV power outputs. Conclusion/Application: In the future, the proposed forecasting system for solar power generation resources will be further refined and run in real environments. Keywords: Distributed Power Generation, Forecasting System, Photovoltaic Power Forecasts, Solar Energy, Wind Power
Abstract 16: Landscape and outcome of TRK fusion-positive Cancers (2020)

Abstract TRK inhibitors achieve marked tumor-agnostic efficacy in TRK fusion-positive cancers and consequently are now an established standard of care. Little is known, however, about the demographics, clinical outcomes, response to alternative standard therapies, or genomic characteristics of TRK fusion-positive cancers. Utilizing a center-wide screening program involving more than 26,000 prospectively sequenced patients, genomic and clinical data from all cases with identified TRK fusions were extracted. An integrated analysis was performed of genomic, therapeutic, and phenomic outcomes. In total, we identified 76 cases with confirmed TRK fusions (0.27% overall prevalence) involving 48 unique rearrangements and 17 distinct cancer types. The presence of a TRK fusion was associated with depletion of concurrent oncogenic drivers (p=4.4E-7) and lower tumor mutation burden (p=4.2E-9), with the exception of colorectal cancer where TRK fusions co-occur with microsatellite instability (MSI-H). Longitudinal profiling in a subset of patients indicated that TRK fusions were present in all sampled timepoints in 82% (14/17) of cases. Progression-free survival on first-line therapy, excluding TRK inhibitors, administered for advanced disease was 9.6 months (95% CI: 4.8-13.2). The best ORR achieved with chemotherapy containing-regimens across all lines of therapy was 63% (95% CI: 41-81). Among 12 patients treated with checkpoint inhibitors, the only response observed was in an MSI-H colorectal patient. TRK fusion-positive cancers can respond to alternative standards of care, although efficacy of immunotherapy in the absence of other predictive biomarkers (MSI-H) appears limited. TRK fusions are present in tumors with simple genomes lacking in concurrent drivers that may partially explain the tumor-agnostic efficacy of TRK inhibitors. Citation Format: Ezra Y. Rosen, Debra A. Goldman, Jaclyn F. Hechtman, Ryma Benayed, Alison M. Schram, Emiliano Cocco, Sophie Shifman, Yixiao Gong, Ritika Kundra, James P. Solomon, Alberto Bardelli, Maurizio Scaltriti, Alexander Drilon, Alexia Iasonos, Barry S. Taylor, David M. Hyman. Landscape and outcome of TRK fusion-positive Cancers [abstract]. In: Proceedings of the AACR Special Conference on Advancing Precision Medicine Drug Development: Incorporation of Real-World Data and Other Novel Strategies; Jan 9-12, 2020; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(12_Suppl_1):Abstract nr 16.
D-109 Invited—Soft-Confinements of Chiral Smectic Phases On Crystallization in the Macroscopic Monodomains of a Main-Chain Non-Racemic Liquid Crystalline Polymer (2007)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.