gebhart/patrepeval huggingface dataset:
RSMA for Hybrid RIS-UAV-Aided Full-Duplex Communications With Finite Blocklength Codes Under Imperfect SIC (2023)

In this work, we consider a hybrid aerial full-duplex (FD) relaying consisting of a reconfigurable intelligent surface (RIS) mounted over an FD unmanned aerial vehicle (UAV) relay operating in decode and forward mode to assist the information transfer between the base station and multiple users. For better spectral efficiency, we investigate the use of rate splitting multiple access (RSMA) in such networks and focus on joint optimization of RSMA parameters, 3D-coordinates of the UAV/RIS, and phase shift matrix at the RIS along with analyzing the outage probability, block error rate (BLER) and achievable weighted sum rate for finite blocklength (FBL) and infinite blocklength (IBL) codes under imperfect successive interference cancellation (SIC) at each user and residual-self interference (RSI) at the UAV. We first formulate the weighted sum rate maximization problem and adopt the block coordinate descent (BCD) method to deal with the non-convex nature of the problem. Thereafter, we propose a BCD-based algorithm that jointly optimizes these parameters using a heuristic approach for optimum power allocation, a Riemannian conjugate gradient-based algorithm to get the optimal phase shift at the RIS, and an iterative algorithm to obtain the optimal UAV/RIS position. It also distributes the common rate among the users optimally. Next, with obtained optimal parameters, we further analyze the performance of the network and derive the closed-form expressions of BLER, outage probability, and average weighted sum rate. We present Monte Carlo simulation-based results to validate the accuracy of the proposed algorithms and derived expressions, and demonstrate the superiority of RSMA over non-orthogonal multiple access (NOMA) and conventional orthogonal multiple access (OMA) schemes.
Learning Aggregation Functions for Expert Search (2010)

Machine learning techniques are increasingly being applied to problems in the domain of information retrieval and text mining. In this paper we present an application of evolutionary computation to the area of expert search. Expert search in the context of enterprise information systems deals with the problem of finding and ranking candidate experts given an information need (query). A difficult problem in the area of expert search is finding relevant information given an information need and associating that information with a potential expert.
J022035 Magnetic resonance elastography using micro MRI to two layered agarose gel (2012)

Magnetic resonance elastography (MRE) is a newly developed imaging technique that makes full use of the magnetic resonance imaging (MRI) visualization to measure the stiffness of tissue in the body organs using mechanical excitation. In this study, an excitation device for MRE by micro-MRI (0.3T) was constructed from a high power vibration generator and a bar type vibration transmitter made from GFRP. The stiffness was expressed by storage shear modulus G' and loss shear modulus G" of the modified stokes model for a viscoelastic medium. Using a micro-MRI system, the optimal excitation condition of frequency and amplitude of wave was examined using some gel specimens. Viscoelastic modulus distribution of two layered agarose gel specimens were measured in the excitation condition of amplitude (0.5, 1.0, and 1.5 mm) and frequency (62.5, 125, and 250 Hz). The distribution of G' was influenced by both the frequency and amplitude of excitation. The two layered specimen combined with two different concentration gel samples shows the same tendency of G' in the same concentration layer approaching similar values under the higher excitation amplitude and frequency conditions as the uniform agarose gel specimen. Clear differences of the wave propagation patterns were observed in the MR image and the difference of G' between each phase area could be measured quantitatively in this MRE system.
19 RNA: The Shape of Things to Come (1993)

This enormous book and the literature behind it establish a new conventional wisdom. Today it is common to assert that an RNA world once existed and flowed into the present biosphere. Introductory texts and review articles softly (or staunchly [Watson et al. 1987]) proclaim that RNA comprises the collection of genetic and catalytic molecules that began the biosphere and then gracefully stepped into the background as a richer life unfolded. In this volume are papers that define the position RNA might have held. Having read many such papers, we note that by the scientific rules of evidence, the concept of an RNA world may stand only as an attractive idea, an idea that never can be tested adequately. One problem is that known RNA catalysts are few, and thus we have no way to assess the catalytic breadth of RNA by normal observation and experimentation. Methods now exist to inspect the catalytic and binding properties of small RNA molecules without recourse to the identification of RNAs in the present biosphere. In this paper, we illustrate the chemical and likely catalytic potential of RNA by reference to work done by us using these new methods. The plausibility and limitations of an early RNA world are addressed by the work. We have come to an astonishing and unexpected conclusion. RNA apparently has a huge distribution of sizes and shapes, and a collection of RNA molecules, even a collection of rather short RNA molecules, could have been used for an enormous variety of...
Cyclopeptide Alkaloids. Phencyclopeptines From Ceanothus sanguineus (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclopeptide Alkaloids. Phencyclopeptines From Ceanothus sanguineusJ. Clark Lagarias, Dane Goff, and Henry RapoportCite this: J. Nat. Prod. 1979, 42, 6, 663–668Publication Date (Print):November 1, 1979Publication History Published online1 July 2004Published inissue 1 November 1979https://pubs.acs.org/doi/10.1021/np50006a013https://doi.org/10.1021/np50006a013research-articleACS PublicationsRequest reuse permissionsArticle Views143Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Unilateral retinitis pigmentosa: Case report and review of the literature (2019)

Significance: Due to the limited number of reported cases little is known about the characteristics of unilateral retinitis pigmentosa. Information from additional case reports can aid in learning more about the condition. We report a case of retinitis pigmentosa that has remained unilateral for 28 years and review the available literature. Case Report: A 40-year-old Caucasian female presented for an opinion as to the cause of her vision loss. Fundus autofluorescence demonstrated hypoautofluorescence in the midperipheral retina and a hyperautofluorescent ring surrounding the area of preserved photoreceptors in the macula. Optical coherence tomography showed disruption of the ellipsoid zone and the external limiting membrane. Electroretinography (ERG) showed severely reduced rod and cone function monocularly. Discussion: Retinitis pigmentosa is typically bilateral and symmetric. Unilateral retinitis pigmentosa is a rare condition that manifests with only one eye having changes typical of retinitis pigmentosa. The unaffected eye can have no signs of retinitis pigmentosa and must have a normal ERG after long-term follow up. It is critical to rule out inflammatory, traumatic, toxic, and cancer associated retinopathy that can present with retinal pigmentary changes. Unilateral retinitis pigmentosa generally remains unilateral, but long-term follow up with ERG is important. There is currently no treatment that can stop the process of retinitis pigmentosa, but gene therapy shows promise.
Gastrorenal Axis (2016)

H ypertension is present in 40% of the world's popula- tion and is responsible for 12.8% of total deaths. 1 In the United States, hypertension affects 32% (2011-2012) of the middle-age (40-59 years) adult population and is responsible for 35.6% of total deaths. 2-4 However, these statistics do not include normotensive individuals who are salt sensitive. Almost half of the US population has hypertension, salt sensitivity, or both. 5 Salt sensitivity, independent of the presence of hypertension, is a risk factor for not only cardiovascular morbidity and mortality Salt sensitivity may also interfere with the normal circadian rhythm of blood pressure. 9 Failure of the normal night-time dip in blood pressure may be associated with an increase in cardiovascular morbidity and mortality. he World Health Organization recommends reducing salt consumption to <5 g of NaCl per day in adults, to help prevent hypertension, heart disease, and stroke. 11 In a recent metaanalysis of randomized controlled trials, it was concluded that in the normotensive population, there is no relationship between the amount of sodium restriction (136-188 mmol/d) and blood pressure level. However, in the prehypertensive and hypertensive populations, reduction in sodium intake (77-140 mmol/d) correlated with a decrease in blood pressure. nother meta-analysis indicated that a modest reduction in salt intake for 4 weeks causes a decrease in blood pressure levels in both hypertensive and normotensive individuals. In subjects with no history of hypertension, no association was found between dietary sodium or potassium intake with hypertension or prehypertension. 14 However, a lower limit of the daily NaCl intake is not defined. This is important because the relationship between sodium intake and blood pressure may not be linear but more of a J-shaped curve. There is evidence for an increase in cardiovascular risk at low levels of sodium ingestion. 9]
Durable Responses to PD-1 Blockade in Mismatch-Repair Deficient Cancers, Independent of Tissue Origin (2018)

The genomes of cancers deficient in mismatch repair (MMR) contain exceptionally high number of somatic mutations. In a proof-of-concept study, we showed that colorectal cancers with MMR deficiency were sensitive to immune checkpoint blockade with anti-PD-1 antibodies. In the current study, we evaluated the efficacy of PD-1 blockade in patients with advanced MMR-deficient cancers across 12 different types. Objective radiographic responses were observed in 53% of patients and complete responses were achieved in 21% of patients. Responses were durable with median progression-free and overall survival still not reached. Functional analysis in a responding patient demonstrated rapid in vivo expansion of neoantigen-specific T cell clones that were reactive to mutant neopeptides found in the tumor. These data support the hypothesis that the very large number of mutant neoantigens in MMR-deficient cancers make them sensitive to immune checkpoint blockade, regardless of the cancers’ tissue of origin.
ORNL Laboratory Directed Research and Development Program FY 2008 Annual Report (2009)

The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries all ORNL LDRD research activities supported during FY 2008. The associated FY 2008 ORNL LDRD Self-Assessment (ORNL/PPA-2008/2) provides financial data and an internal evaluation of the program’s management process.
Frequency Multiplexed Raster Scheme Of An Optical Neural Network: Shift Invariant Recognition. (1989)

We develop and optically implement a Spatial Raster scheme for image recognition with neural nets. With this coding, two dimensional optical elements can be used throughout the system.
Optimization of the in-beam OpenPET detector for carbon beam irradiation (2012)

We are developing the OpenPET which is well suited to in-beam PET in carbon ion therapy thanks to the open space. The in-beam PET can image the distribution of positron emitters during beam irradiation for in-situ dose monitoring. Therefore careful designing and testing of OpenPET detectors are important because secondary particles generated in a target degrade detector performance in the OpenPET geometry and the quantity of positron emitters produced in in-beam PET is very small. In this paper, we optimized the final design of the in-beam OpenPET detector. Some detector components were changed from our previous work for use under practical situations. We carried out in-beam tests of this new detector for <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sup> C beam irradiation with practical intensities. The constructed OpenPET detector consists consisted of a 16 × 16 × 4 crystal array with four-layer DOl encoding capability and a position-sensitive photomultiplier tube (PS-PMT). The scintillator material was changed from LGSO that included radio isotopes to GSOZ. In order to compensate for the lower light yield of GSOZ, we applied the PS-PMT (R10552-100-M64) with the super bialkali photocathode which realizes 30% higher quantum efficiency than the conventional bialkali type. A large current divider circuit was applied since the PMT current exceeded the dynamic range of a normal divider circuit under the targeted practical situations. Irradiation tests were done in HIMAC. The energy and intensities of the <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sup> C beam were 290MeV/u and 1.0 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> particles per second (pps), respectively. The detector was positioned 30cm from the backside of the water phantom at an angle of 30deg. We obtained sufficient crystal identification performance around 1.0 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> pps, although the position histogram was degrading slightly with increasing <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sup> C beam intensity. The energy resolutions of 15.2% (1st layer), 14.6% (2nd layer), 13.6% (3rd layer) and 12.5% (4th layer) were obtained for single crystal elements. We concluded that the constructed detector was able to function as the OpenPET detector for in-beam imaging.
Private Similarity Searchable Encryption for Euclidean Distance (2017)

In this paper, we propose a similarity searchable encryption in the symmetric key setting for the weighted Euclidean distance, by extending the functional encryption scheme for inner product proposed by Bishop et al. [4]. Our scheme performs predetermined encoding independently of vectors x and y, and it obtains the weighted Euclidean distance between the two vectors while they remain encrypted.
Performance of Silicone Rubber Composite Insulators in Sri Lanka (2006)

This paper presents the performance of silicone rubber composite insulators in Sri Lanka over ten years period. The study consisted of two phases. In the first phase (from 1995-1999), different types of composite insulators were installed in 33 kV distribution network and were tested under marine, industrial (cement dust) and clean environments. Based on the outcomes of these tests a new set of silicone rubber insulators was selected for the phase two (2001-2006) of the project under marine and clean environments. It was found that the silicone rubber insulators performed well during this period and there is a possibility for stressing such insulators higher than ordinary porcelain insulators. Further it was found that housing material composition influenced the performance of insulators stronger than the creepage distance
Providing Cooperative Data Analytics for Real Applications Using Machine Learning (2019)

This paper presents a data analytics system which determines optimal analytics algorithms by selectively testing a wide range of different algorithms and optimizing parameters using Transformer-Estimator Graphs. Our system is applicable to situations in which multiple clients need to perform calculations on the same data sets. Our system allows clients to cooperate in performing analytics calculations by sharing results and avoiding redundant calculations. Computations may be distributed across multiple nodes, including both client and server nodes. We provide multiple options for dealing with changes to data sets depending upon the data consistency requirements of applications. Another key contribution of our work is the Transformer-Estimator Graph, a system for specifying a wide variety of options to use for machine learning modeling and prediction. We show how Transformer-Estimator Graphs can be used for analyzing time series data. A key feature that we provide for making our system easy to use is solution templates which are customized to problems in specific domains.
ChemInform Abstract: Zinc Chloride Doped Natural Phosphate as 1,3‐Dipolar Cycloaddition Catalyst. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cycloaddition Reactions and Dendritic Polymer Architectures – A Perfect Match (2007)

Summery: The potential of cycloaddition (CA) reactions for the synthesis of dendritic polymers is pointed out. The [4 + 2] Diels Alder cycloaddition as well as 1,3-dipolar CA reactions including “click chemistry” are addressed, and the advantages of these reactions like high selectivity, thus high tolerance towards additional functionalities, high yields and synthesis under mild reaction conditions are highlighted. New perfectly branched dendrimers as well as hyperbranched polymers have been prepared and modified using the 1,3-dipolar cycloaddition reaction of azines with alkynes. The 1,3-dipolar CA reaction of bisazine with maleimides results in hyperbranched and thus, irregular and broadly distributed polymers though with a degree of branching of 100% due to special intermediate formation. The [4 + 2] Diels Alder cycloaddition was successfully applied for the synthesis of highly branched polyphenylene structures using the AB2 + AB and the A2 + B3 approach. CA reactions are also very suitable for highly efficient polymer analogous reactions and thus, they can also be used to prepare complex polymer architectures like dendronized polymers.
Supplemental Data from Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer (2023)

&lt;p&gt;Supplemental Table 1 and Figures 1 and 2&lt;/p&gt;
Neuron-specific ablation of the Krabbe disease gene galactosylceramidase in mice results in neurodegeneration (2022)

Krabbe disease is caused by a deficiency of the lysosomal galactosylceramidase (GALC) enzyme, which results in the accumulation of galactosylceramide (GalCer) and psychosine. In Krabbe disease, the brunt of demyelination and neurodegeneration is believed to result from the dysfunction of myelinating glia. Recent studies have shown that neuronal axons are both structurally and functionally compromised in Krabbe disease, even before demyelination, suggesting a possible neuron-autonomous role of GALC. Using a novel neuron-specific Galc knockout (CKO) model, we show that neuronal Galc deletion is sufficient to cause growth and motor coordination defects and inflammatory gliosis in mice. Furthermore, psychosine accumulates significantly in the nervous system of neuron-specific Galc-CKO. Confocal and electron microscopic analyses show profound neuro-axonal degeneration with a mild effect on myelin structure. Thus, we prove for the first time that neuronal GALC is essential to maintain and protect neuronal function independently of myelin and may directly contribute to the pathogenesis of Krabbe disease.
Observation of Robust Néel Skyrmions in Metallic PtMnGa (2019)

Abstract Over the past decade the family of chiral noncollinear spin textures has continued to expand with the observation in metallic compounds of Bloch-like skyrmions in several B20 compounds, and antiskyrmions in a tetragonal inverse Heusler. Néel like skyrmions in bulk crystals with broken inversion symmetry have recently been seen in two distinct nonmetallic compounds, GaV4S8 and VOSe2O5 at low temperatures (below ≈13 K) only. Here, the first observation of bulk Néel skyrmions in a metallic compound PtMnGa and, moreover, at high temperatures up to ≈220 K is reported. Lorentz transmission electron microscopy reveals the chiral Néel character of the skyrmions. A strong variation is reported of the size of the skyrmions on the thickness of the lamella in which they are confined, varying by a factor of 7 as the thickness is varied from ≈90 nm to ≈4 µm. Moreover, the skyrmions are highly robust to in-plane magnetic fields and can be stabilized in a zero magnetic field using suitable field-cooling protocols over a very broad temperature range to as low as 5 K. These properties, together with the possibility of manipulating skyrmions in metallic PtMnGa via current induced spin–orbit torques, make them extremely exciting for future spintronic applications.