gebhart/patrepeval huggingface dataset:
Characterization of inositol 1,4,5-trisphosphate- and inositol 1,3,4,5-tetrakisphosphate-binding sites in rat cerebellum (1991)

1. The properties of specific Ins(1,4,5)P3- and Ins(1,3,4,5)P4-binding sites have been compared in a crude 'P2' cerebellar membrane fraction. 2. A homogeneous population of [3H]Ins(1,4,5)P3-binding sites was present (KD 23.1 +/- 3.6 nM) at high density (Bmax. 11.9 +/- 1.8 pmol/mg of protein); whereas data obtained for [32P]Ins(1,3,4,5)P4 specific binding were best fitted to a two-site model, the high-affinity binding component (KD 2.6 +/- 0.7 nM) constituted 64.2 +/- 4.3% of the total population and was present at relatively low density (Bmax. 187 +/- 27 fmol/mg of protein). 3. The two high-affinity inositol polyphosphate-binding sites exhibited markedly different pH optima for radioligand binding, allowing the two sites to be independently investigated. At pH 8.0, [3H]Ins(1,4,5)P3 binding was maximal, whereas [32P]Ins(1,3,4,5)P4 specific binding was very low; conversely, at pH 5.0, [32P]Ins(1,3,4,5)P4 binding was maximal, whereas [3H]Ins(1,4,5)P3 binding was undetectably low. 4. Both inositol polyphosphate-binding sites exhibited marked positional and stereo-specificity. Of the analogues studied, only phosphorothioate substitution to form inositol 1,4,5-trisphosphorothioate was tolerated at the Ins(1,4,5)P3-binding site, with only a 2-3-fold loss of binding activity. Addition of a glyceroyl moiety at the 1-phosphate position or addition of further phosphate substituents at the 3- or 6-positions caused dramatic losses in displacing activity. Similarly, complete phosphorothioate substitution of Ins(1,3,4,5)P4 caused an approx. 6-fold loss of binding activity at the [32P]Ins(1,3,4,5)P4-binding site, whereas Ins(1,4,5,6)P4, Ins(1,3,4,6)P4, Ins(1,4,5)P3 and Ins(1,3,4,5,6)P5 were bound at least 100-fold weaker at this site. Therefore, only the phosphorothioate derivatives retained high affinity and selectivity for the two inositol polyphosphate-binding sites. 5. Heparin and pentosan polysulphate were potent but non-selective inhibitors at Ins(1,4,5)P3- and Ins(1,3,4,5)P4-binding sites. N-Desulphation (with or without N-reacetylation) of heparin decreased inhibitory activity at the Ins(1,4,5)P3-, but not at the Ins(1,3,4,5)P4-binding site; however, the selectivity of this effect was only about 4-fold. O- and N-desulphated N-reacetylated heparin was essentially inactive at both sites. 6. The results are discussed with respect to the separate identities of the inositol polyphosphate-binding sites.
Accurate Discrete-Time Modeling for Improved Torque Control Accuracy for Induction Machine Drives at Very Low Sampling-to-Fundamental Frequency Ratios (2019)

Operations at low sampling-to-fundamental frequency (S2F)ratios of induction machines are required for high-power or high-speed applications. The traditional indirect field-oriented control is open-loop control on torque, which is sensitive to machine parameters and degrades at low S2F ratios. Deadbeat-direct torque and flux control (DB-DTFC)is closed-loop control on torque but also degrades at low S2F ratios with discrete-time approximations. This paper presents accurate discrete-time modeling for the flux and current observer and the deadbeat controller used in DB-DTFC. Experimental results show that the torque control accuracy is significantly improved even at very low S2F ratios.
Real-Time Discharge/Charge Rate Management for Hybrid Energy Storage in Electric Vehicles (2014)

Electric vehicles (EVs) are equipped with a large number of expensive battery cells, necessitating an effective battery management system (BMS) which protects the battery cells from harsh conditions while providing the required power efficiently. The discharge/charge rate affects battery health significantly, and existing BMSes employ simple discharge/charge rate scheduling so as to prevent weak cells from excessive discharge/charge. In this paper, we design and evaluate the real-time management of battery discharge/charge rate to extend battery life for EVs based on the physical dynamics and operation history of batteries. We first explore a modern energy storage system for EVs to capture physical dynamics and their impact on the battery discharge/charge rate, for example, a regenerative braking system for reusing the dissipated energy leads to current surges into the batteries, which shortens battery life. Based on understanding of the effects of discharge/charge rate in an energy storage system, we devise control knobs for manipulating the rate. Then, we design an adaptive discharge/charge rate management algorithm that determines the control knobs with a reconfigurable energy storage architecture. Our in-depth evaluation results demonstrate that the proposed discharge/charge rate management improves battery life up to 37.7% at little additional cost over the existing energy storage systems.
Electromagnetic Containerless Processing of Single-walled Nanotube Reinforced Metal-Matrix Composites (2005)

Single-walled carbon nanotube (SWNT) reinforced copper (Cu) matrix composites were produced by powder metallurgy (PM) and electromagnetic levitation methods. The nanotubes were first decorated with a nickel coating and then dispersed by ball milling. The optimization of factors such as cold pressing pressure, powder grain size and sintering temperature for full densification were essential in the preform stage of PM in order to produce a sample suitable for levitation. Scanning electron microscopy (SEM) observations have shown that the well-dispersed nanotubes in the composites are not damaged during the high-temperature composite preparation. The preforms were then melted by electromagnetic levitation in an argon environment. SEM observations showed that the nanotubes survived the high-temperature melting. Hardness testing demonstrated that the strength of the composites is increased with increasing volume fraction of SWNTs.
Complex Coacervation and Precipitation Between Soluble Pea Proteins and Apple Pectin (2022)

Abstract Complex formation (leading to either coacervation or precipitation) offers a tool to generate plant-based novel food structures and textures. This study investigated the formation of complexes between soluble pea proteins and apple pectin upon varying the protein-to-pectin ratio ( r = 2:1 to 10:1), pH (3–7), and temperature (25 and 85 °C) with a total biopolymer concentration set to 1% (w/w). The results showed that predominantly soluble biopolymer complexes were formed at pH 5, and at low ratio ( r = 2:1), whereas lowering the pH to more acidic condition, and to higher ratios ( r = 4:1–10:1) induced the formation of more insoluble biopolymer complexes. In general, the mean particle sizes of the biopolymer complexes ranged between approximately 20 and 100 μm. Upon heating to 85 °C, the amount of insoluble biopolymer complexes increased at pH 3–5 at all ratios, except at r = 2:1. In addition, the complex sizes became somewhat larger at r = 2:1 to 6:1 upon heat treatment, whereas only trivial size changes were observed at higher ratios ( r = 8:1 to 10:1). Overall, electrostatic and hydrophobic interactions played a major role in the complex formation between the soluble pea proteins and apple pectin. These findings are important for designing solely plant-based food structures.
Commissioning an EUV mask microscope for lithography generations reaching 8 nm (2013)

The SEMATECH High-NA Actinic Reticle review Project (SHARP) is a synchrotron-based, EUV-wavelength microscope, dedicated to photomask imaging, now being commissioned at Lawrence Berkeley National Laboratory. In terms of throughput, resolution, coherence control, stability and ease of use, SHARP represents a significant advance over its predecessor, the SEMATECH Berkeley Actinic Inspection Tool (AIT), which was decommissioned in September 2012. SHARP utilizes several advanced technologies to achieve its design goals: including the first Fouriersynthesis illuminator on a zoneplate microscope, EUV MEMS mirrors, and high-efficiency freestanding zoneplate lenses with numerical aperture values up to 0.625 (4&times;). In its first week of operation, SHARP demonstrated approximately 150 times higher light throughput than AIT and a spatial resolution down to 55-nm half-pitch with 0.42 4&times;NA (i.e. the smallest feature size on our test mask.) This paper describes the current status of the tool commissioning and the performance metrics available at this early stage.
A CMOS analog front-end IC for portable EEG/ECG monitoring applications (2005)

A new digital programmable CMOS analog front-end (AFE) IC for measuring electroencephalograph or electrocardiogram signals in a portable instrumentation design approach is presented. This includes a new high-performance rail-to-rail instrumentation amplifier (IA) dedicated to the low-power AFE IC. The measurement results have shown that the proposed biomedical AFE IC, with a die size of 4.81 mm/sup 2/, achieves a maximum stable ac gain of 10 000 V/V, input-referred noise of 0.86 /spl mu/ V/sub rms/ (0.3 Hz-150 Hz), common-mode rejection ratio of at least 115 dB (0-1 kHz), input-referred dc offset of less than 60 /spl mu/V, input common mode range from -1.5 V to 1.3 V, and current drain of 485 /spl mu/A (excluding the power dissipation of external clock oscillator) at a /spl plusmn/1.5-V supply using a standard 0.5-/spl mu/m CMOS process technology.
22.1 A 90GS/s 8b 667mW 64&#x00D7; interleaved SAR ADC in 32nm digital SOI CMOS (2014)

Forthcoming optical communication standards such as ITU OTU-4 and 100/400Gb/s Ethernet require ADCs with more than 50GS/s and at least 5 ENOB to enable complex equalization in the digital domain. SAR ADCs and interleaved ADCs made impressive progress in recent years. First CMOS ADCs with at least 6b and conversion rates exceeding 20GS/s were presented, proving that interleaved SAR ADCs are an optimal choice for high-speed ADCs with moderate resolution. We present an interleaved CMOS ADC architecture based on an asynchronous redundant SAR ADC core element. It was measured up to a sampling rate of 100GS/s and can be operated from a single supply voltage. At 90GS/s, the measured SNDR stays above 36.0dB SNDR up to 6.1GHz and 33.0dB up to 19.9GHz input frequency while consuming 667mW. The ADC is implemented in 32nm digital SOI CMOS and occupies 0.45mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Discussion of Test Results of a Superconductor Synchronous Condenser on a Utility Grid (2007)

An 8 MVAR, 13.8 kV superconducting dynamic synchronous condenser (SDSC) prototype was tested on the Tennessee valley authority (TVA) grid for about a year. It shared a bus with an arc furnace. The SDSC was subjected to transient currents and harmonics created by the arc furnace, which consisted of up to 50% negative sequence and 20% zero sequence components. The SDSC operated successfully in the presence of such high transient/harmonic currents. It provided cycle by cycle correction of voltage during operation. The benefits of voltage correction were observed both at the local bus and at the generator bus of a power generation station several miles away. Currently two commercial units rated 12 MVAR, 13.8 kV, are on order by TVA and are scheduled for delivery in December 2006 and March 2007. These units will be skid-mounted for easy installation on site. This paper discusses test results of the prototype unit operation on the grid and describes its potential applications for voltage support in wind farms.
The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia (2007)

Waldenstrom macroglobulinemia (WM) is an incurable low-grade lymphoplasmacytic lymphoma. We demonstrate up-regulated Akt activity in WM, and that Akt down-regulation by Akt knockdown and the inhibitor perifosine leads to significant inhibition of proliferation and induction of apoptosis in WM cells in vitro, but not in normal donor peripheral blood and hematopoietic progenitors. Importantly, down-regulation of Akt induced cytotoxicity of WM cells in the bone marrow microenvironment (BMM) context. Perifosine induced significant reduction in WM tumor growth in vivo in a subcutaneous xenograft model through inhibition of Akt phosphorylation and downstream targets. We also demonstrated that Akt pathway down-regulation inhibited migration and adhesion in vitro and homing of WM tumor cells to the BMM in vivo. Proteomic analysis identified other signaling pathways modulated by perifosine, such as activation of ERK MAPK pathway, which induces survival of tumor cells. Interestingly, MEK inhibitor significantly enhanced perifosine-induced cytotoxicity in WM cells. Using Akt knockdown experiments and specific Akt and PI3K inhibitors, we demonstrated that ERK activation is through a direct effect, rather than feedback activation, of perifosine upstream ERK pathway. These results provide understanding of biological effects of Akt pathway in WM and provide the framework for clinical evaluation of perifosine in WM patients.
Effect of passive transfer of anti-MSP3 and anti-glurp antibodies on Plasmodium falciparum growth in vitro and in vivo (2003)

Trabalho apresentado no Annual Meeting on Basic Research in Chagas Disease, 30.; Meeting of the Brazilian Society of Protozoology, 19., 2003, Caxambu.
Principal Component Analysis in CGAL (2008)

Principal component analysis is a basic component of many geometric computing and processing algorithms. It is most commonly used on point sets, although applicable as well to sets of arbitrary primitives through the computation of covariance matrices. In this paper we provide closed form formulas of covariance matrices for sets of 2D and 3D geometric primitives such as segments, circles, triangles, iso rectangles, spheres, tetrahedra and iso cuboids. We also describe the method of deriving covariance matrices for their dimensional variants such as disks, balls etc. We finally discuss the flexibility and added value of the present approach by discussing its potential use in applications. Our implementation will be available through the next release of the CGAL library.
Current–voltage characteristics of Schottky diodes at high current densities under the injection of minority carriers (2017)

An analytical expression is derived for the current–voltage characteristic of a Schottky diode at a high injection level of minority carriers. It is shown that, even at very high current densities, the higher the base doping level, the larger the voltage drop across the diode. The physical mechanism responsible for this “paradoxical” result is analyzed. The validity of the analytical result is confirmed by a numerical calculation with software that takes into account the whole set of nonlinear effects caused by a high injection level in the base layer and by heavy doping of the emitter region.
Interactive Ambiguity Resolution of Named Entities in Fictional Literature (2017)

Abstract Named entity recognition (NER) denotes the task to detect entities and their corresponding classes, such as person or location, in unstructured text data. For most applications, state of the art NER software is producing reasonable results. However, as a consequence of the methodological limitations and the well‐known pitfalls when analyzing natural language data, the NER results are likely to contain ambiguities. In this paper, we present an interactive NER ambiguity resolution technique, which enables users to create (post‐processing) rules for named entity recognition data based on the content and entity context of the analyzed documents. We specifically address the problem that in use‐cases where ambiguities are problematic, such as the attribution of fictional characters with traits, it is often unfeasible to train models on custom data to improve state of the art NER software. We derive an iterative process model for improving NER results, show an interactive NER ambiguity resolution prototype, illustrate our approach with contemporary literature, and discuss our work and future research.
A case of monogenic diabetes mellitus caused by a novel heterozygous RFX6 nonsense mutation in a 14-year-old girl (2021)

It may be worth investigating genetic etiology in early-onset autoantibody-negative DM for specific genetic diagnosis and better management.
Three Tesla Multiparametric Magnetic Resonance Imaging: Comparison of Performance with and without Endorectal Coil for Prostate Cancer Detection, PI-RADS™ version 2 Category and Staging with Whole Mount Histopathology Correlation (2018)

We found that 3 Tesla multiparametric magnetic resonance imaging with and without an endorectal coil had similar detection of overall and index prostate cancer. However, the endorectal coil subcohort had significantly higher detection of posterior and peripheral prostate cancer, and lower detection of anterior and transition zone prostate cancer.
Xyloglucan-Derivatized Films for the Culture of Adherent Cells and Their Thermocontrolled Detachment: A Promising Alternative to Cells Sensitive to Protease Treatment (2012)

By taking advantage of a natural and abundant polymer as well as a straightforward film formation technique, this paper focuses on the conception and use of a new alternative tool for thermo-controlled cell detachment. Thermoresponsive xyloglucan was produced after partial galactose removal by a 24 h reaction with β-galactosidase. The obtained polymer (T24) was then activated by reaction with 4-nitrophenyl chloroformate (NPC) in order to graft a cyclic peptide presenting an arginine-glycine-aspartic acid (RGD) motif. The effect of RGD grafting on the sol-gel transition temperature of T24 is evaluated by rheological measurements. Solvent-casted films of T24-RGD successfully promoted cell adhesion, proliferation, and thermo-controlled detachment. The presented approach is a new alternative for cells sensitive to the proteolytic treatment routinely used for cell detachment. Because the RGD sequence used herein is widely recognized by different cell types, this protocol may be extended to other cells. Besides, the presented chemical route can be applied to different peptide sequences.
Preparative Organic Photochemistry (Schonberg, Alexander) (1969)

ADVERTISEMENT RETURN TO ISSUEPREVBook and Media Revie...Book and Media ReviewPreparative Organic Photochemistry (Schonberg, Alexander)Douglas C. Neckers Cite this: J. Chem. Educ. 1969, 46, 12, A901Publication Date (Print):December 1, 1969Publication History Received3 August 2009Published online1 December 1969Published inissue 1 December 1969https://doi.org/10.1021/ed046pA901.2RIGHTS & PERMISSIONSArticle Views146Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (684 KB) Get e-Alerts Get e-Alerts
Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the ApcMin model of colorectal cancer (2017)

// Sarah L. Dombernowsky 1,* , Jeanette Schwarz 1,* , Jacob Sams&oslash;e-Petersen 1 , Reidar Albrechtsen 1 , Kim B. Jensen 1,2 , Gary Thomas 3 and Marie Kveiborg 1 1 Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark 2 Novo Nordisk Foundation Center for Stem Cell Biology, University of Copenhagen, Copenhagen, Denmark 3 Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA * These authors have contributed equally to this work Correspondence to: Marie Kveiborg, email: // Keywords : DSS-induced colitis; colon cancer; ApcMin model; PACS-2; ADAM17 Received : May 07, 2017 Accepted : October 28, 2017 Published : November 26, 2017 Abstract PACS-2 is a multifunctional sorting protein that mediates cell homeostasis. We recently identified PACS-2 in a functional genome-wide siRNA screen for novel regulators of the metalloproteinase ADAM17, the main sheddase for ligands of the ErbB receptor family. Of note, we showed that Pacs2 -/- mice have significantly reduced EGFR activity and proliferative index in the intestinal epithelium. As EGFR signaling is highly mitogenic for intestinal epithelial stem cells, and plays essential roles in intestinal epithelial regeneration and tumor development, we have now examined the role of PACS-2 in these processes. Specifically, we analyzed the role of Pacs 2-deficiency in a DSS-induced colitis model as well as in the genetic Apc Min colon cancer model. We now report that loss of PACS-2 delays tissue regeneration after colonic injury with little effect on key inflammatory parameters. We did however not observe any apparent effects on tumor formation driven by excessive proliferative signaling downstream from APC-deficiency. Our findings reveal that the role of PACS-2 in regulating ADAM17-mediated shedding is not an obligate requirement for the epithelium to respond to the strong inflammatory or tumorigenic inducers in the models assessed here.
Transplantation tolerance after allograft rejection (2016)

We have reviewed clinical and experimental data to explain how transplantation tolerance may be achieved in individuals who have experienced allograft rejection.
Improving Accuracy of Ray-Tracing Prediction in Non Line-of-Sight (NLOS) Urban Street Cell Environment beyond 6GHz (2016)

Recently, mobile networks employing high-speed high-capacity communications have been investigated extensively to satisfy the demand for faster and higher-capacity data communications. In one approach, frequencies between 6 and 100GHz are candidates to utilize relatively wide frequency bandwidths. Accordingly, radio propagation loss in these frequency bands must be characterized. Ray-tracing (RT) is the most common modeling approach to predict propagation loss in site-specific scenarios. The accuracy of RT simulations has been investigated in urban street cell environments based on comparison to measurement results and we observed that the difference between RT simulation and measurement results tends to increase as the frequency increases. In this paper, we focus on the shape of building corners at an intersection because it is this shape that is a dominant contributing factor in the region away from the intersection. In order to correct the error in the conventional RT method, we propose an alternative model that considers the detailed shape of the building corner and surface roughness. The performance of the RT simulation using the proposed method is then investigated based on comparison of two different sets of measurement results. Finally, we extract the optimal size and roughness for the proposed modeling method. Consequently, we confirm that using the proposed method with optimized parameters significantly enhances the accuracy compared to the conventional method.