gebhart/patrepeval huggingface dataset:
Table S2 from A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance (2023)

&lt;p&gt;Resistance index values of DJ101 measured in drug sensitive PC-3 and DU-145 and their corresponding taxane resistant sublines.&lt;/p&gt;
Unusual cause of acute lower extremity ischemia in a healthy 15-year-old female: A case report and review of popliteal artery aneurysm management in adolescents (2016)

Limb ischemia in healthy teenagers is unusual. While traumatic or iatrogenic injury is the most common etiologies of limb ischemia in the pediatric population, anatomic variants such as true aneurysms should be considered [1]. We report the second documented pediatric case of an idiopathic, isolated true popliteal aneurysm resulting in acute limb ischemia in a previously healthy 15-year-old female. We also review the proper evaluation and surgical management of this anatomic anomaly. In this case, surgical management included resection of the aneurysm, reconstruction with reverse saphenous vein grafting, and distal endarterectomies to restore adequate distal blood flow. Ultimately, this patient's limb and function were salvaged with minimal consequences.
The load as an energy asset in a distributed architecture (2005)

As future naval ships become more electrically integrated, the ability to manage the total energy resources becomes critical. Currently these functions are available only through a centralized controller, which limits flexibility, reconfigurability, and reliability. These limitations can be avoided, and still provide system level coordination through distributed controls based on local information.
Influence of rhBMP-2 on the Healing Patterns Associated With Allograft Interbody Constructs in Comparison With Autograft (2006)

We think that the use of rhBMP-2 is a promising method of facilitating allograft dowel incorporation and new bone formation in patients undergoing ALIF with allograft dowels.
Molecular cytogenetic analysis of consistent abnormalities at 8q12-q22 in breast cancer (1998)

Studies using comparative genomic hybridization (CGH) indicate that portions of chromosome arm 8q from 8q12 to 8qter are present at an increased relative copy number in a broad range of solid tumors. In this study we define an approximately 1 Mb wide region that appears to be frequently abnormal in copy number or structure in breast cancer cell lines and primary tumors. This was accomplished by fluorescence in situ hybridization (FISH) with yeast artificial chromosomes (YACs) mapped to 8q2-q22. Eleven breast cancer cell lines and ten primary tumors were analyzed. A minimal region of rearrangement was localized to the CEPH-YAC 928F9 in three breast cancer cell lines with unbalanced translocation breakpoints mapping in this region. Unbalanced translocations also were detected in two primary tumors mapping between CEPH-YAC clones 890C4 and 936B3, flanking 928F9. An increased copy number in the minimal region was detected in nine cell lines and in multiple primary tumors. This suggests the possibility that a single gene mapping to 928F9 is involved in breast cancer development or progression and may be deregulated by copy number increases in some tumors and by translocation in others. Four expressed sequence tags were mapped to YAC 928F9 and analyzed for rearrangements by Southern analysis and for abnormal expression by Northern analysis.
Long term thermo-oxidative degradation and stabilization of polypropylene (PP) and the implications for its recyclability (2023)

Degradation and stabilization of pristine polypropylene (PP) have been extensively studied especially from the 1980s until the first years of the 21st century. As a result of the increasing importance of the recycling of PP, its degradation and stabilization became again relevant. Differently from virgin grades, post-consumer PP presents distinct chemical moieties formed due to degradation, affecting its thermo-oxidative stability. To support studies on the mechanical recycling of PP, this review presents an outline of the chemical reactions leading to PP's degradation and the mechanisms of action of the most relevant stabilizers. Emphasis is given to the heterogeneous degradation of PP and its infectious spreading, in addition to the influence of stabilizers on this phenomenon, as these characteristics are of major importance for the proper stabilization of PP during its first lifetime cycle, which allows its recyclability.
Procedures for Evaluating Un-designed Manure Storage Facilities in New York State (2006)

The New York State Concentrated Animal Feeding Operation (CAFO) permit requires that manurestorages be designed and built following the Natural Resources Conservation Service (NRCS) NY313Standard. Because a large number of existing storages were built before the CAFO program inception, it islikely that a large percentage do not meet the NY313 Standard. These storages are categorized as undesigned.<br><br>Large CAFOs in New York State (NYS) have until 31 December 2006 to fully implement their CAFO plans; thisincludes addressing manure storage(s) on their farms that do not meet or have not been assessed and foundto substantially meet the NY313 Standard. Similarly, medium CAFOs have until 2009 to fully implement theirplan requirements.<br><br>A recent catastrophic failure of an un-designed earthen storage in NYS has put even more emphasis on thisissue. A procedure has been developed to evaluate un-designed storages. The evaluation process takes intoaccount the existing facility, the watershed and location on the landscape, geology and soils, condition of thefacility, and test results from soil and water samples. The results of the evaluation can show that the storagefacility is good as is, needs continued monitoring, needs to be improved, needs improved maintenance, orneeds to be closed.
Severe corneal dystrophy phenotype caused by homozygous R124H keratoepithelin mutations. (1998)

The severe phenotype was a pathologic variant of granular corneal dystrophy (GCD). All five patients had homozygous R124H keratoepithelin mutations. The R124H keratoepithelin mutation is the same mutation recently reported to be responsible for Avellino corneal dystrophy. The homozygous R124H keratoepithelin mutations are the cause of the severe variant of GCD characterized by juvenile-onset and confluent superficial opacity.
ASM-024, a Piperazinium Compound, Promotes the In Vitro Relaxation of β2-Adrenoreceptor Desensitized Tracheas (2015)

Inhaled β2-adrenoreceptor agonists are widely used in asthma and chronic obstructive pulmonary disease (COPD) for bronchoconstriction relief. β2-Adrenoreceptor agonists relax airway smooth muscle cells via cyclic adenosine monophosphate (cAMP) mediated pathways. However, prolonged stimulation induces functional desensitization of the β2-adrenoreceptors (β2-AR), potentially leading to reduced clinical efficacy with chronic or prolonged administration. ASM-024, a small synthetic molecule in clinical stage development, has shown activity at the level of nicotinic receptors and possibly at the muscarinic level and presents anti-inflammatory and bronchodilator properties. Aerosolized ASM-024 reduces airway resistance in mice and promotes in-vitro relaxation of tracheal and bronchial preparations from animal and human tissues. ASM-024 increased in vitro relaxation response to maximally effective concentration of short-acting beta-2 agonists in dog and human bronchi. Although the precise mechanisms by which ASM-024 promotes airway smooth muscle (ASM) relaxation remain unclear, we hypothesized that ASM-024 will attenuate and/or abrogate agonist-induced contraction and remain effective despite β2-AR tachyphylaxis. β2-AR tachyphylaxis was induced with salbutamol, salmeterol and formoterol on guinea pig tracheas. The addition of ASM-024 relaxed concentration-dependently intact or β2-AR desensitized tracheal rings precontracted with methacholine. ASM-024 did not induce any elevation of intracellular cAMP in isolated smooth muscle cells; moreover, blockade of the cAMP pathway with an adenylate cyclase inhibitor had no significant effect on ASM-024-induced guinea pig trachea relaxation. Collectively, these findings show that ASM-024 elicits relaxation of β2-AR desensitized tracheal preparations and suggest that ASM-024 mediates smooth muscle relaxation through a different target and signaling pathway than β2-adrenergic receptor agonists. These findings suggest ASM-024 could potentially provide clinical benefit when used adjunctively with inhaled β2-adrenoreceptor agonists in those patients exhibiting a reduced response to their chronic use.
Charge transport and filament formation in ZnS:Mn thin film structures (2007)

The charge carrier dynamics and pattern formation in ac‐driven ZnS:Mn thin‐film electroluminescent devices is studied on the basis of a drift‐diffusion approach. The hysteresis of the current‐voltage characteristic and the properties of current filaments in the bistable region are analyzed for two different models of the impact ionization coefficient.
The role of Cathepsin S as a marker of prognosis and predictor of chemotherapy benefit in adjuvant CRC: a pilot study (2011)

These results signify that CatS may be an important prognostic biomarker and predictive of response to adjuvant FU/FA in CRC.
Electromigration, fuse and thermo-mechanical performance of solder bump versus Cu pillar flip chip assemblies (2011)

Two different flip chip bump configurations have been investigated in terms of their thermo-mechanical, electromigration and fusing behaviour. Standard SAC (SnAgCu) solder bumps with a Ni/Au finish on the chip side are compared with Cu pillar bumps soldered with a thin layer of SnAg alloy. For the test structure, the flip chip assembly is integrated in a BGA package. Finite Element Modelling is used to support the experimental work and explain some of the conclusions.
Synthesis and self assembly of eosin functionalized amphiphilic block-random copolymers prepared by ring opening metathesis polymerization Part A Polymer chemistry (2008)

Self assembly of block copolymers has gained considerable attention because of its potential use in various areas such as medical and biomedical applications, nanotechnology, and electronics. Herein, we present the synthesis and characterization of amphiphilic block-random copolymers with a covalently incorporated pH-sensitive dye, namely eosin. Ring opening metathesis polymerization was chosen for the preparation of well defined block copolymers and block-random copolymers using a modified 2nd Generation Grubbs initiator. The self assembly behavior of the block-random copolymers in solution was studied by dynamic light scattering and small angle X-ray scattering (SAXS). The influence of dye incorporation on the result of the self assembly process in methanol and ethanol was investigated and a subtle interplay of the nature of the selective solvent, the chain-length of the block copolymer and the position of the dye within the polymer chain was established. Structural investigations using SAXS revealed a spherical shape and a core-shell structure of exemplary block and block-random copolymer micelles. UV-vis absorption and photoluminescence measurements revealed similar optical properties for polymer micelles in methanol compared to polymer solutions in THF. The pH-sensitive behavior of the eosin dye was preserved within the micelles. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 401-413, 2008
Position and speed sensorless control for PMSM drive using direct position error estimation (2002)

A new position and speed sensorless control approach is proposed for permanent magnet synchronous motor (PMSM) drives. The controller directly computes an error for the estimated rotor position and adjusts the speed according to this error. The derivation of the position error equation and an idea for eliminating the differential terms, are presented. The proposed approach is applied to a vector controlled PMSM AC drive and phase locked loop (PLL) control is employed for speed adjustment. Several simulations are carried out. The proposed control scheme is verified by experiments using a 3.7 kW salient pole PMSM.
Color processing for multi-primary display devices (2005)

Today's display devices are incapable of reproducing the full color range that humans can perceive; hence, color gamut expansion technology has become an active area of research. Among other things, the multi-primary display (MPD) device has received much attention lately because it provides simple and effective mechanisms for widening the color gamut. However, MPD has problems related to over-determined systems and metamerism. This paper seeks to provide solutions to these problems by proposing a cusp mapping method to address gamut mapping issues and LUT implementation of dimension reduction of over-determined systems to address primary decomposition issues. The proposed methods were tested on a 5-primary DLP/sup TM/ projection television. The experimental results address metamerism issues and show increasing as much as 20% at the color-reproducing region that the most common 3-primary DLP/sup TM/ projection television can not reproduce.
An Analysis of Object Representations in Deep Visual Trackers (2020)

Fully convolutional deep correlation networks are integral components of state-of the-art approaches to single object visual tracking. It is commonly assumed that these networks perform tracking by detection by matching features of the object instance with features of the entire frame. Strong architectural priors and conditioning on the object representation is thought to encourage this tracking strategy. Despite these strong priors, we show that deep trackers often default to tracking by saliency detection - without relying on the object instance representation. Our analysis shows that despite being a useful prior, salience detection can prevent the emergence of more robust tracking strategies in deep networks. This leads us to introduce an auxiliary detection task that encourages more discriminative object representations that improve tracking performance.
Heart Failure Spending Function: An Investment Framework for Sequencing and Intensification of Guideline-Directed Medical Therapies (2022)

Heart failure with reduced ejection fraction is managed with increasing numbers of guideline-directed medical therapies (GDMT). Benefits tend to be additive. Burdens can also be additive. We propose a heart failure spending function as a conceptual framework for tailored intensification of GDMT that maximizes therapeutic opportunity while limiting adverse events and patient burden. Each patient is conceptualized to have reserve in physiological and psychosocial domains, which can be spent for a future return on investment. Key domains are blood pressure, heart rate, serum creatinine, potassium, and out-of-pocket costs. For each patient, GDMT should be initiated and intensified in a sequence that prioritizes medications with the greatest expected cardiac benefit while drawing on areas where the patient has ample reserves. When reserve is underspent, patients fail to gain the full benefit of GDMT. Conversely, when a reserve is fully spent, addition of new drugs or higher doses that draw upon a domain will lead to patient harm. The benefit of multiple agents drawing upon varied physiological domains should be balanced against cost and complexity. Thresholds for overspending are explored, as are mechanisms for implementing these concepts into routine care, but further health care delivery research is needed to validate and refine clinical use of the spending function. The heart failure spending function also suggests how newer therapies may be considered in terms of relative value, prioritizing agents that draw on different spending domains from existing GDMT.
Structural studies of group 5B–halide–dithio-ligand complexes. Part 3. Crystal structure of polymeric (NN-diethyldithiocarbamato)di-iodobismuth(III) (1981)

The crystal structure of the title compound, [Bi(S2CNEt2)l2], has been determined by single-crystal X-ray diffraction methods at 295(1) K and refined by least-squares procedures to a conventional residual of 0.045 for 1 537 ‘observed’ reflections. Crystals are monoclinic, space group P21/c, with a= 10.673(3), b= 15.001(3), c= 8.149(2)Å, β= 90.86(2)°, and Z= 4. The structure comprises an infinite linear polymeric array, successive bismuth atoms being bridged by a pair of iodine atoms and a ligand sulphur atom.
New Radical Homoallylation Reactions. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Technical demonstration session: Software toolflow for FPGA bitstream obfuscation (2016)

Reconfigurable hardware, such as Field Programmable Gate Arrays (FPGAs), are being increasingly deployed in diverse application areas including automotive systems, critical infrastructures, and the emerging Internet of Things (loT), to implement customized designs. However, securing FPGA-based designs against piracy, reverse engineering, and tampering is challenging, especially for systems that require remote upgrade. In many cases, existing solutions based on bitstream encryption may not provide sufficient protection against these attacks. In our paper (Karam et aI., “Robust Bitstream Protection in FPGA-based Systems through Low-Overhead Obfuscation”, ReConFig 2016), we presented a novel obfuscation approach for provably robust protection of FPGA bitstreams with low overhead. In this demonstration, we show how our custom software can integrate with a commercial FPGA toolflow for securing designs on existing hardware.
ChemInform Abstract: THE REGIOSELECTIVITY OF THE CYCLOADDITIONS OF KETENES WITH N‐ALKYL‐ AND N‐ARYLNITRONES (1978)

Abstract Die Arylnitrone (I) führen mit Cyclopentamethylenketeri, tert.‐Butylcarbethoxy‐keten oder tert.‐Butyl‐cyano‐keten in Toluol zu den Oxazolidinonen (II) und (III), jedoch nicht zu Azetidinonen.
Supplementary Table 2 from MicroRNA Signatures in Human Ovarian Cancer (2023)

Supplementary Table 2 from MicroRNA Signatures in Human Ovarian Cancer
Effect of measurement error budgets and hybrid metrology on qualification metrology sampling (2014)

Until now, metrologists had no statistics-based method to determine the sampling needed for an experiment before the start that accuracy experiment. We show a solution to this problem called inverse total measurement uncertainty (TMU) analysis, by presenting statistically based equations that allow the user to estimate the needed sampling after providing appropriate inputs, allowing him to make important “risk versus reward” sampling, cost, and equipment decisions. Application examples using experimental data from scatterometry and critical dimension scanning electron microscope tools are used first to demonstrate how the inverse TMU analysis methodology can be used to make intelligent sampling decisions and then to reveal why low sampling can lead to unstable and misleading results. One model is developed that can help experimenters minimize sampling costs. A second cost model reveals the inadequacy of some current sampling practices—and the enormous costs associated with sampling that provides reasonable levels of certainty in the result. We introduce the strategies on how to manage and mitigate these costs and begin the discussion on how fabs are able to manufacture devices using minimal reference sampling when qualifying metrology steps. Finally, the relationship between inverse TMU analysis and hybrid metrology is explored.
Abstract 1361: Fragment based drug discovery of selective inhibitors of Fibroblast Growth Factor Receptor (FGFR) (2011)

Abstract Recent data in a number of tumour types has implicated Fibroblast Growth Factor (FGF) and Fibroblast Growth Factor receptor (FGFR) signalling as being key to the molecular pathology of cancer. A fragment screening campaign was conducted against the tyrosine kinase domain of FGFR1 to detect low molecular weight compounds that bound to the hinge region of the kinase. The screening produced several fragment inhibitors (molecular weight &amp;lt;250 Da) in the micromolar range and their binding modes were confirmed by X-ray crystallography. We selected an imidazo[1,2-a]pyridine fragment that was 120 uM versus FGFR3 in the kinase inhibition bioassay. Subsequently, in the fragments-to-leads stage a detailed structural understanding of the binding interactions between the fragment and its protein kinase target, using X-ray crystallography, led to the identification of a 0.003 uM inhibitor of FGFR3 in the kinase bioassay, with significant selectivity versus VEGFR2 and FLT3. The poster will focus on the description of previously undescribed compounds bearing an imidazo[1,2-a]pyridine core scaffold where selectivity versus other protein kinases, for example FLT3, is obtained using the X-ray crystal structure and structure-based design. In summary we will illustrate how X-ray crystallography and fragment-based drug design (FBDD) can be used to discover compounds with activity in an FGFR driven xenograft model when dosed by the oral route. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1361. doi:10.1158/1538-7445.AM2011-1361
Recent Advances in Music Signal Processing [From the Guest Editors] (2018)

In this special issue of IEEE Signal Processing Magazine (SPM), we survey recent advances in music processing with a focus on audio signals. Eleven articles cover topics including music analysis, retrieval, source separation, singing-voice processing, musical sound synthesis, and user interfaces, to name a few. The tutorial-style articles provide an overview of theory and applications and discuss main advances. Although music processing has benefited a lot from traditional fields, such as signal processing, we hope to convince the reader that the rich and challenging problem domain of music also has many things to offer to signal processing and other research disciplines.
Impurity diffusion in ion implanted AlN layers on sapphire substrates by thermal annealing (2022)

Abstract We report on impurity diffusion in ion implanted AlN layers after thermal annealing. Silicon, tin, germanium, and magnesium ions were implanted into single-crystal Al-polar AlN layers grown on sapphire substrates. By annealing at 1600 °C, silicon and magnesium atoms were diffused in the AlN layer, while less change was observed in the distribution of germanium atoms. Silicon implantation introduced vacancy-related defects. By annealing at temperatures over 1300 °C, the vacancy-related defects were reduced, while oxygen atoms were diffused from the substrate due to sapphire decomposition. We reproducibly achieved silicon-implanted AlN layers with electrical conductance by controlling the annealing temperature and distribution of silicon and oxygen concentrations.
High resolution 14N NMR in solids: Single crystals of ammonium hydrogen oxalate hemihydrate (1977)

Proton decoupled 14N NMR spectra of ammonium hydrogen oxalate (AHOX) single crystals have been employed to determine the electric field gradient tensor at the 14N sites. Despite the 99.4% abundance of 14N, the spectral lines are narrow (∼300 Hz) and show two inequivalent 14NH4+ ions with (e2qQ/h) =130 kHz, η=0.39 and (e2qQ/h) =350 kHz, η=0.27. On the basis of motional averaging arguments, we surmise that these nonvanishing field gradients arise primarily because of lattice distortions of the N–H distances. The results indicate that it should be relatively easy to obtain 14N spectra in single crystals, and thus to examine a number of phenomena which have heretofore been inaccessible.