gebhart/patrepeval huggingface dataset:
Tratamento em regime compulsivo ambulatório: estudo de follow-up após um ano em Portugal (2017)

Enquadramento: Não existem evidências suficientes relativamente ao impacto do tratamento em regime compulsivo ambulatório (TCA). Objetivos: Avaliámos o impacto do TCA ao longo de um ano em sintomas, funcionamento pessoal e social, insight e cognição. Métodos: Análise naturalística, longitudinal, no início e no follow-up após um ano, de 15 pacientes seguidos numa consulta especializada de TCA. Os pacientes foram submetidos a avaliação estandardizada com o Positive and Negative Syndrome Scale (PANSS) (Escala Positiva e Negativa do Síndroma), Personal and Social Performance Scale (PSP) (Escala de Desempenho Pessoal e Social), Berrios-Markova Scale to Assess Unawareness in Mental Disorder (SUMD) (Escala de Avaliação da Falta de Consciência no Distúrbio Mental), Trails A e B, Digit Span, e o Controlled Oral Word Association Test (COWA) (Teste de Associação Verbal Controlada). Resultados: No follow-up houve melhorias significativas no funcionamento pessoal e social (PSP inicial total: média=46,9; follow-up: média=59,3), e nomeadamente nas atividades socialmente úteis incluindo trabalho e estudos (p=0,012) e relações pessoais e sociais (p=0,033). Três pacientes (20%) pontuaram =&gt;69 no PSP, um bom nível de funcionamento. Porém, não verificámos melhorias significativas nos sintomas (PANSS=56,8), insight subjetivo ou objetivo (Berrios-Markova=10,0 e SUMD=11,0), ou desempenho cognitivo. Conclusões: No follow-up após um ano, os pacientes em TCA revelaram melhorias significativas no funcionamento pessoal e social, especificamente nas atividades socialmente úteis incluindo trabalho e estudos e nas relações pessoais e sociais, mas não registaram melhorias nos sintomas, insight e funcionamento cognitivo.
T1ρ‐based dynamic glucose‐enhanced (DGEρ) MRI at 3 T: method development and early clinical experience in the human brain (2019)

DGEρ imaging was optimized for clinical field strengths of 3 T, and a robust protocol was established for broader application. Early experience shows that DGEρ seems possible at 3 T and could not only be attributed to motion artifacts. Observed DGEρ maps showed unique patterns, partly matching with the T<sub>1</sub> -ce tumor ring enhancement. However, effect sizes are small and careful clinical application is necessary.
Tumorigenic and Metastatic Activity of Human Thyroid Cancer Stem Cells (2010)

Thyroid carcinoma is the most common endocrine malignancy and the first cause of death among endocrine cancers. We show that the tumorigenic capacity in thyroid cancer is confined in a small subpopulation of stem-like cells with high aldehyde dehydrogenase (ALDH(high)) activity and unlimited replication potential. ALDH(high) cells can be expanded indefinitely in vitro as tumor spheres, which retain the tumorigenic potential upon delivery in immunocompromised mice. Orthotopic injection of minute numbers of thyroid cancer stem cells recapitulates the behavior of the parental tumor, including the aggressive metastatic features of undifferentiated thyroid carcinomas, which are sustained by constitutive activation of cMet and Akt in thyroid cancer stem cells. The identification of tumorigenic and metastagenic thyroid cancer cells may provide unprecedented preclinical tools for development and preclinical validation of novel targeted therapies.
Thermal Inactivation of Foot-and-Mouth Disease Virus in Milk Using High-Temperature, Short-Time Pasteurization (2007)

Previous studies of laboratory simulation of high temperature, short time pasteurization (HTST) to eliminate foot-and-mouth disease virus (FMDV) in milk have shown that the virus is not completely inactivated at the legal pasteurization minimum (71.7 degrees C/15 s) but is inactivated in a flow apparatus at 148 degrees C with holding times of 2 to 3 s. It was the intent of this study to determine whether HTST pasteurization conducted in a continuous-flow pasteurizer that simulates commercial operation would enhance FMDV inactivation in milk. Cows were inoculated in the mammary gland with the field strain of FMDV (01/UK). Infected raw whole milk and 2% milk were then pasteurized using an Arm-field pilot-scale, continuous-flow HTST pasteurizer equipped with a plate-and-frame heat exchanger and a holding tube. The milk samples, containing FMDV at levels of up to 10(4) plaque-forming units/mL, were pasteurized at temperatures ranging from 72 to 95 degrees C at holding times of either 18.6 or 36 s. Pasteurization decreased virus infectivity by 4 log10 to undetectable levels in tissue culture. However, residual infectivity was still detectable for selected pasteurized milk samples, as shown by intramuscular and intradermal inoculation of milk into naïve steers. Although HTST pasteurization did not completely inactivate viral infectivity in whole and 2% milk, possibly because a fraction of the virus was protected by the milk fat and the casein proteins, it greatly reduced the risk of natural transmission of FMDV by milk.
Networks of non-homogeneous M/G/∞ systems (1994)

For a network of G/ ∞ service facilities, the transient joint distribution of the facility populations is shown by new simple methods to have a simple Poisson product form with simple explicit formulas for the means. In the network it is assumed that: (a) each facility has an infinite number of servers; (b) the service time distributions are general; (c) external traffic is non-homogeneous in time; (d) arrivals have random or deterministic routes through the network possibly returning to the same facility more than once; (e) arrivals use the facilities on their route sequentially or in parallel (as in the case of a circuitswitched telecommunication network). The results have relevance to communication networks and manufacturing systems.
An iterative search algorithm for designing the bend of an H-plane bend radiator (2010)

A design approach to obtain the function defining the bend that minimizes the reflected power into the feed waveguide of a structure, called the H-plane bend radiator (HPB radiator) is presented. The HPB radiator is used as a part of a high-power antenna and therefore there is a requirement for a smooth bend containing no sharp corners. As the smoothness requirement on the H-plane bend function increases, the possible number of functions to be considered in search of a solution increases; this increases the complexity of the problem. It is hypothesized that the general design philosophies in the approach can be adopted as a basis for designing other structures with bends similar to the H-plane bend in the HPB radiator. © 2010 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2010.
Synergistic antitumor activity of histone deacetylase inhibitors and anti-ErbB3 antibody in NSCLC primary cultures via modulation of ErbB receptors expression (2016)

ErbB3, a member of the ErbB family receptors, has a key role in the development and progression of several cancers, including non-small cell lung cancer (NSCLC), and in the establishment of resistance to therapies, leading to the development of anti-ErbB3 therapies.In this study we demonstrated, in a set of malignant pleural effusion-derived cultures of NSCLC, the synergistic antitumor effect of a histone deacetylase inhibitor (HDACi), such as vorinostat or valproic acid (VPA), in combination with the anti-ErbB3 monoclonal antibody (MoAb) A3. Synergistic interaction was observed in 2D and in 3D cultures conditions, both in fully epithelial cells expressing all ErbB receptors, and in cells that had undergone epithelial to mesenchymal transition and expressed low levels of ErbB3. We provided evidences suggesting that differential modulation of ErbB receptors by vorinostat or VPA, also at low doses corresponding to plasma levels easily reached in treated patients, is responsible for the observed synergism. In details, we showed in epithelial cells that both vorinostat and VPA induced time- and dose-dependent down-regulation of all three ErbB receptors and of downstream signaling. On the contrary, in A3-resistant mesenchymal cells, we observed time- and dose-dependent increase of mRNA and protein levels as well as surface expression of ErbB3, paralleled by down-regulation of EGFR and ErbB2. Our results suggest that the combination of a HDACi plus an anti-ErbB3 MoAb represents a viable strategy that warrants further evaluation for the treatment of NSCLC patients.
Estimations of Milk and Meat Withdrawal Times of Ketamine and Lidocaine in Adult Holstein Cows (2006)

Ketamine is a dissociative anesthetic commonly used for short-term and induction of anesthesia in bovine species. Ketamine has recently become popular for use as a constant-rate infusion for continuous pain relief. Lidocaine, a local anesthetic, is frequently used for local infiltration and epidural nerve blocks. Two of the most common local blocks in adult cattle are the inverted-L local infiltration and caudal epidural nerve blocks. These blocks are utilized for numerous standing surgical procedures such as cesarean sections, obstetric manipulations, correction of a displaced abomasum and perineal surgery. These animals may occasionally be sent for slaughter following a surgical procedure, and the Food and Drug Administration (FDA) has a zero-tolerance policy for drug residues in meat and milk. There is limited information and no published data on meat and milk withdrawal times for ketamine anesthesia or lidocaine administration via these two different techniques. The objectives of this study were to investigate the pharmacokinetics of ketamine following administration of a single intravenous dose and lidocaine administered via inverted-Land caudal epidural nerve blocks, and to establish the withdrawal times for meat and milk of these two anesthetics in mature Holstein cows.
Dominant factors determining the threshold voltage for thin-film electroluminescent devices (1989)

The dominant factors determining electric-field clamping for thin-film electroluminescent devices are described. It is shown that clamped electric-fields depend on emission layer conductivity. Clamped electric-field strengths decrease with increases in conductivity, which can be controlled by emission-layer preparation methods and growth conditions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
&#x201C;Tweaking&#x201D; the Pigment Color for Advanced Printing Applications (2011)

The color of organic pigments for commercial printing applications, commonly considered as invariable, can be &#x201C;tweaked&#x201D; by adjusting chemical environments surrounding the pigment particles. The extend of color change, though small, is frequently noticeable with a naked eye. This phenomenon is due to subtle interactions between the surface molecules of the pigment and surrounding polar moieties either chemisorbed or vicinal to the pigment surface. Detailed understanding of this effect may allow avoiding undesirable color changes degrading the printed color quality. It may also be used in development of advanced inks for various printing applications.
Achievement of Higher-k and High-Φ in Phase Controlled HfO2 Film Using Post Gate Electrode Deposition Annealing (2007)

Cubic-HfO2 film was formed by the post-gate-electrode-deposition annealing (PGA) process and the highest permittivity 39 was obtained. The optical bandgap (Ф) is also confirmed to be as wide as that of the low-permittivity monoclinic phase. Thus higher-k and high-Ф is achieved in cubic-HfO2 films. We found, however, that the permittivity degrades sensitively with both gate-electrode structure and PGA temperature. Analyses using x-ray diffraction, far-infrared spectroscopy, and TEM observation revealed that the cubic phase is not stable and orthorhombic and tetragonal phases appear in the degraded films. We calculated the stress in stacked structures during annealing and obtained the relationship between the stress in HfO2 films and the crystalline phases. It is shown that the stress induced in HfO2 through the PGA process has a strong impact on controlling the crystalline phases and thus the permittivity.
Molecular Modeling of Biological Electron Transfer via Molecular Recognition. Synthetic Receptor for Ubiquinone and Cytochrome c. (1998)

Electron transfer (ET) reaction in biological systems plays an important role in respiratory oxidative phosphorylation and photosynthesis. In the respiratory system, two electron carriers, ubiquinone and cytochrome c, control the overall reaction of ET process via specific interaction with membrane-bound oxidoreductases. The present review describes two topics of the synthetic modeling of noncovalently linked donor-acceptor systems using porphyrin unit; (1) preparation and characterization of ubiquinone receptors by use of a functional porphyrin, which shows the photoinduced ET reaction within the porphyrin-quinone complex formed by hydrogen bonding interaction. (2) construction of binding sites on the surface of myoglobin and mimicking of protein-protein complexation. In this review, I wish to report the suitable model systems to evaluate the intermolecular ET of the electron carriers via molecular recognition.
Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFδ/δ mouse model of amyotrophic lateral sclerosis (2010)

Downregulation of these genes involved in axon outgrowth and synapse formation in adult mice suggests a hitherto unrecognized role of VEGF in the maintenance of neuronal circuitry. Dysregulation of VEGF may lead to neurodegeneration through synaptic regression and dying-back axonopathy.
Lymphocyte Electrotaxis In Vitro and In Vivo (2008)

Electric fields are generated in vivo in a variety of physiologic and pathologic settings, including penetrating injury to epithelial barriers. An applied electric field with strength within the physiologic range can induce directional cell migration (i.e., electrotaxis) of epithelial cells, endothelial cells, fibroblasts, and neutrophils suggesting a potential role in cell positioning during wound healing. In the present study, we investigated the ability of lymphocytes to respond to applied direct current (DC) electric fields. Using a modified Transwell assay and a simple microfluidic device, we show that human PBLs migrate toward the cathode in physiologically relevant DC electric fields. Additionally, electrical stimulation activates intracellular kinase signaling pathways shared with chemotactic stimuli. Finally, video microscopic tracing of GFP-tagged immunocytes in the skin of mouse ears reveals that motile cutaneous T cells actively migrate toward the cathode of an applied DC electric field. Lymphocyte positioning within tissues can thus be manipulated by externally applied electric fields, and may be influenced by endogenous electrical potential gradients as well.
Bad medicine: clinical examination (2017)

We read with interest the letter from Lloyd warning of the danger of colchicine overdose 1 and agree that this can have devastating consequences. However, the majority of overdoses involve analgesics, antidepressants, hypnotics, anxiolytics, and antipsychotic medications whereas colchicine overdose appears to be an uncommon occurrence. [2] 3] lthough we concur with Lloyd that assessment of mood and risk of overdose should be considered when prescribing any medication, we urge prescribers not to abandon an effective treatment for this excruciatingly painful and frequently poorly managed condition.
Effects of medicinal plants of the genus Leonurus and seventeen of their isolated constituents on the activity of PPARα, β/δ, and γ in an in vitro luciferase reporter gene assay (2015)

Previously, we reported the effects of Leonurus japonicus Houtt. – used in TCM against the metabolic syndrome – and its N-containing constituents leonurine and stachydrine on the PPAR system [1]. However, no active constituents could be identified. Here we describe the isolation of 17 further dominant constituents of L. japonicus and the related European herb Leonurus cardiaca L. – namely 7R-chloro-6-desoxy-harpagide [2], ajugol, campneoside II, chicoric acid, ferulic acid, harpagide, isoacteoside, isocampneoside II, isoleosibirin, lavandulifolioside, leonoside A, rutin, and verbascoside, as well as four new phenylethanoids described here for the first time with the preliminary names LC139C, LC138C, LC141B, and LC140A1 – and their screening for activity on the metabolic syndrome related targets PPARα, β/δ, and γ in the above mentioned luciferase reporter gene assay [3]. All 17 isolated constituents (at 6.25, 25, 50, and 100 µg/mL each), and GW0742 (positive control, 0.1 nM) were dissolved in DMSO and added to the medium of the COS-1 cells, transfected as described at [1, 3]. For PPARα and γ, the positive controls WY14643 (50 µM) and troglitazone (10 µM), respectively, were used. In this assay, only 7R-chloro-6-desoxy-harpagide, which was recently isolated by our group for the first time [2], displayed significant activity in the PPARβ/δ assay at 50 µg/mL while the result for 100 µg/mL was even higher than for the GW0742 positive control. Furthermore, rutin at 100 µg/mL showed weak PPARα agonistic activity. For PPARγ no significant effects were observed. This activity of extracts of medicinal plants of the genus Leonurus and especially of their active constituent 7R-chloro-6-desoxy-harpagide on the PPARβ/δ subtype of the PPAR system strongly indicates their potential for anti-obesity therapy.
First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288 (2017)

Type I positive allosteric modulators (PAMs) of the alpha7-nicotinic receptor enhance its cholinergic activation while preserving the spatiotemporal features of synaptic transmission and the receptor's characteristic rapid desensitization kinetics. Alpha7-nicotinic receptor agonists have shown promise for improving cognition in schizophrenia, but longer-term trials have been disappointing. Therefore, the type I PAM AVL-3288 was evaluated for safety and preliminary evidence of neurocognitive effect in healthy human subjects. Single-dose oral administration in ascending doses was conducted in a double-blind, placebo-controlled Phase I trial in non-smokers. The trial found indication of positive but non-significant effects on neurocognition at 10 and 30 mg, two doses that produced overlapping peak levels. There was also some evidence for effects on inhibition of the P50 auditory evoked potential to repeated stimuli, a biomarker that responds to alpha7-nicotinic receptor activation. The pharmacokinetic characteristics were consistent between subjects, and there were no safety concerns. The effects and safety profile were also assessed at 3 mg in a cohort of smokers, in whom concurrent nicotine administration did not alter either effects or safety. The trial demonstrates that a type I PAM can be safely administered to humans and that it has potential positive neurocognitive effects in central nervous system (CNS) disorders.
Erratum to: “Composite Materials on the Basis of Phenylenecarboxylate Framework MOF-5 and Calix[4]arenes with Various Structures” (2011)

A comparative study of the texture and adsorption characteristics of newly synthesized composite materials based on 1,4-benzenedicarboxylate metal-organic framework MOF-5 and calix[4]arenes with various structures was performed.
Impact of magnetic field on molecular alignment and electrical conductivity in phthalocyanine nanowires (2012)

We demonstrate the effective use of a magnetic field to improve molecular alignment, and the resulting enhancement of the electrical conductivity of organic molecular nanowires. The structures of phthalocyanine nanowires, which are produced in porous alumina templates, are characterized by X-ray diffraction. Careful analyses reveal that the crystal morphologies of the phthalocyanine nanowires, e.g., domain size, columnar alignment and face-to-face spacing, are improved by using a 12 T magnetic field. This is because of the anisotropic magnetic susceptibility of the π-conjugated phthalocyanine macrocycle. Electrical measurements of individual nanowires performed with a multi-probe scanning electron microscope show that such highly ordered molecular packing results in a seventeen-fold increase in conductivity.
ChemInform Abstract: Cytotoxic and Antivascular 1‐Methyl‐4‐(3‐fluoro‐4‐methoxyphenyl)‐5‐(halophenyl)‐imidazoles. (2012)

Abstract New N‐methylimidazole bridged analogues (VI) (8 examples) of combretastatin A‐4 are synthesized and evaluated for their cytotoxicity and antiangiogenic activity.
VNA-Based Testbed for Accurate Linearizability Testing of RF Beamforming Arrays Under Modulated Signals (2023)

This paper presents a vector network analyzer (VNA) based testbed for accurate phased arrays linearity and linearizability testing under wideband modulated signals. The proposed testbed relies on a standard horn based channel calibration to de-embed over-the-air receiver hardware frequency response and utilizes two of the VNA’s receivers to simultaneously capture accurate representation of the array input and radiated signals. The testbed corrects the linear and nonlinear distortions exhibited by the transmitter underlying components (e.g., arbitrary waveform generator, up-converter, driver amplifiers, and couplers) as well as for the channel and receiver hardware frequency responses so that the linearizability testing is solely indicative of the performance of the array under test. Experiments conducted using an 8x8 RF beamforming array operated at 28 GHz confirmed the capacity of the proposed testbed to support digital predistortion based linearization testing under 5G NR 400 MHz OFDM test signal. More importantly, the pre- correction of the linear and nonlinear distortions exhibited by the testbed yielded an improvement of the adjacent channel power ratios of the array radiated signal by up to 2-3 dB compared to the uncorrected case while using 48% less number of coefficients.
A Small Molecule RIG-I Agonist Serves as an Adjuvant to Induce Broad Multifaceted Influenza Virus Vaccine Immunity (2023)

Retinoic acid-inducible gene I (RIG-I) is essential for activating host cell innate immunity to regulate the immune response against many RNA viruses. We previously identified that a small molecule compound, KIN1148, led to the activation of IFN regulatory factor 3 (IRF3) and served to enhance protection against influenza A virus (IAV) A/California/04/2009 infection. We have now determined direct binding of KIN1148 to RIG-I to drive expression of IFN regulatory factor 3 and NF-κB target genes, including specific immunomodulatory cytokines and chemokines. Intriguingly, KIN1148 does not lead to ATPase activity or compete with ATP for binding but activates RIG-I to induce antiviral gene expression programs distinct from type I IFN treatment. When administered in combination with a vaccine against IAV, KIN1148 induces both neutralizing Ab and IAV-specific T cell responses compared with vaccination alone, which induces comparatively poor responses. This robust KIN1148-adjuvanted immune response protects mice from lethal A/California/04/2009 and H5N1 IAV challenge. Importantly, KIN1148 also augments human CD8+ T cell activation. Thus, we have identified a small molecule RIG-I agonist that serves as an effective adjuvant in inducing noncanonical RIG-I activation for induction of innate immune programs that enhance adaptive immune protection of antiviral vaccination.