gebhart/patrepeval huggingface dataset:
Assessment of risk of overall and late distant recurrence by Breast Cancer Index in postmenopausal women with early-stage, HR+ breast cancer in the TEAM trial. (2023)

509 Background: Individual risk assessment of distant recurrence (DR) is particularly relevant for early-stage HR+ breast cancer patients, as they face a prolonged risk of recurrence even after adjuvant endocrine therapy. Previously, we have shown that the Breast Cancer Index (BCI) and BCIN+ risk groups are significantly prognostic for risk of overall (0-10y) and late (5-10y) distant recurrence in N0 and N1 breast cancer patients, respectively, enrolled in the Tamoxifen and Exemestane Adjuvant Multinational (TEAM) trial. Here, the prognostic performance of BCI and BCIN+ as a continuous risk score for overall and late distant recurrence was evaluated in the TEAM trial. Methods: BCI testing was performed blinded to clinical outcome with BCI/BCIN+ risk scores calculated as previously described. Cox proportional hazard models adjusted for age, tumor size, grade and treatments were used to estimate hazard ratios (HRs) and the associated 95% confidence intervals (CIs) for BCI/ BCIN+ continuous risk scores. The 10y risk of overall and late DR were estimated as a function of risk scores from the Cox models using Breslow estimates. Results: Continuous risk curves for overall and late DR were obtained in patients who did not receive adjuvant chemotherapy and those who remained DR-free at 5 years regardless of chemotherapy, respectively, to reflect the two key time points for breast cancer treatment decision-making. InN0 patients not treated with chemotherapy (N = 1197), BCI was significantly prognostic for overall DR with a HR of 1.39 (95% CI 1.25-1.54; p &lt; 0.001), while BCIN+ was significantly prognostic in N1 patients who did not receive chemotherapy (N = 1319) with a HR of 4.29 (95% CI 2.93-6.28; p &lt; 0.001). Among patients who remained DR-free at 5 years, in the N0 subset (N = 1285), BCI was significantly prognostic for late DR with a HR of 1.23 (95% CI 1.07-1.42; p &lt; 0.001), while BCIN+ remained to be significantly prognostic in the N1 subset (N = 1762) with a HR of 2.78 (95% CI 1.75-4.43; p &lt; 0.001). Similar results were observed in the HER2- subset for both overall and late DR. Continuous risk curves for BCI and BCIN+ for overall and late DR showed an increasing risk of DR with higher BCI/BCIN+ scores. Conclusions: Results from this largest BCI study to date further support the use of BCI to provide individualized risk estimates for both overall and late DR in women with HR+ breast cancer to aid in personalized decision-making for adjuvant therapy. [Table: see text]
Scanning probe optical microscopy using an integrated submicron organic photodetector (2008)

A high-resolution scanning optical microscopy technique is developed by using focused ion beam milling and vacuum thermal evaporation to fabricate an organic photodetector with sub-micron size on a scanning probe cantilever. Optical and topographic data are recorded simultaneously and demonstrate sub-micron resolution. Potential applications of the probe include materials characterization, biology, and nanophotonics, and are aided by the fact that the probe is compatible with conventional atomic force microscopy (AFM) systems and does not suffer some of the practical difficulties of existing near-field scanning optical microscopy (NSOM) systems.
Spatio-Temporal Signatures of User-Centric Data: How Similar Are We? (2015)

Much work has been done on understanding and predicting human mobility in time. In this work, we are interested in obtaining a set of users who are spatio-temporally most similar to a query user. We propose an efficient way of user data representation called Spatio-Temporal Signatures to keep track of complete record of user movement. We define a measure called Spatio-Temporal similarity for comparing a given pair of users. Although computing exact pairwise Spatio-Temporal similarities between query user with all users is inefficient, we show that with our hybrid pruning scheme the most similar users can be obtained in logarithmic time with in a (1+\epsilon) factor approximation of the optimal. We are developing a framework to test our models against a real dataset of urban users.
Handover performance with HIP and MIPv6 (2005)

Mobility management in the current Internet is designed to work with mobile IPv4 and, when IPv6 is available, with mobile IPv6. These solutions are based on the current architecture in the Internet, where the IP address represents both the locator and the identifier of the node. In the IETF, identity and location information separation has raised a lot of discussion and new ideas have emerged to separate these. Host identity protocol is one candidate that can be used for this separation. It introduces also a new way of handling mobility management taking advantage on the mentioned identity and location separation.
Establishment of a Model to Examine the Early Events Involved in the Development of Virus‐Induced Demyelinating Lesions (2007)

The ability to study the immediate, early events in the demyelinating process has been difficult on account of the lack of model systems that address this phase of lesion development. The vast majority of animal models used to study multiple sclerosis (MS) focuses on the later events of myelin destruction. To address this deficiency, we have modified the currently used Theiler's murine encephalomyelitis virus (TMEV)-induced model of demyelination to precisely identify the area where virus-induced demyelination first occurs. Following surgical exposure of the spinal cord, we directly injected TMEV into the spinal cord of female SJL/J mice. Characterization of the events in the spinal cord in the days following injection of virus support the use of this model to dissect the pathways triggered in the host in the early phases of demyelination. A complete understanding of the genesis of the sclerotic plaque may provide insights into enhanced treatment for patients with central nervous system (CNS) demyelination.
Comment: New digital signature scheme based on discrete logarithm (1994)

The purpose of this Comment is to show that the digital signature scheme based on the discrete logarithm problem proposed by Yen and Laih (ibid., vol. 29, no. 12, p. 1120-1, 1993) is vulnerable to substitution attack like other similar signature schemes based on discrete exponentiation in their basic form. It means that given a valid signature of a known message, it is computationally feasible to generate a valid signature of another different known message without the knowledge of the private key. Substitution is typically prevented by the use of a hash function or a redundancy generating function. >
Correction to “UV Protection and Singlet Oxygen Quenching Activity of Aloesaponarin I” (2012)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to "UV Protection and Singlet Oxygen Quenching Activity of Aloesaponarin I"Shin-ichi Nagaoka*, Akiko Fujii, Megumi Hino, Mai Takemoto, Misaki Yasuda, Mariko Mishima, Keishi Ohara, Akane Masumoto, Hidemitsu Uno, and Umpei NagashimaCite this: J. Phys. Chem. B 2012, 116, 7, 2338Publication Date (Web):February 9, 2012Publication History Published online9 February 2012Published inissue 23 February 2012https://pubs.acs.org/doi/10.1021/jp300771qhttps://doi.org/10.1021/jp300771qcorrectionACS PublicationsCopyright © 2012 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views339Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (101 KB) Get e-Alertsclose Get e-Alerts
Introduction (2006)

Suddenly, systems biology is everywhere. What is it? How did it arise? The driving force for its growth is high-throughput (HT) technologies that allow us to enumerate biological components on a large scale. The delineation of the chemical interactions of these components gives rise to reconstructed biochemical reaction networks that underlie various cellular functions. Systems biology is thus not necessarily focused on the components themselves, but on the nature of the links that connect them and the functional states of the networks that result from the assembly of all such links. The stoichiometric matrix represents such links mathematically based on the underlying chemistry, and the properties of this matrix are key to determining the functional states of the biochemical reaction networks that it represents.
Pulmonary Migration of Coils Inserted for Treatment of Erectile Dysfunction Caused by Venous Leakage (1993)

Embolization of penile veins by coils and/or detachable balloons has been reported as a possible effective form of treatment of venogenic erectile dysfunction. The major appeal for this avenue of therapy in these patients is the reported low morbidity and negligible rate of complications compared to an open operation. We describe a case of asymptomatic pulmonary migration of a coil placed for venous leakage in a patient in whom the procedure was conducted through the femoral vein rather than the deep dorsal vein. We conclude that patients undergoing coil embolization for venous leakage should be appraised of the potential for coil migration.
Arthrobots (2017)

This article describes a class of robots-"arthrobots"-inspired, in part, by the musculoskeletal system of arthropods (spiders and insects, inter alia). Arthrobots combine mechanical compliance, lightweight and simple construction, and inexpensive yet scalable design. An exoskeleton, constructed from thin organic polymeric tubes, provides lightweight structural support. Pneumatic joints modeled after the hydrostatic joints of spiders provide actuation and inherent mechanical compliance to external forces. An inflatable elastomeric tube (a "balloon") enables active extension of a limb; an opposing elastic tendon enables passive retraction. A variety of robots constructed from these structural elements demonstrate (i) crawling with one or two limbs, (ii) walking with four or six limbs (including an insect-like triangular gait), (iii) walking with eight limbs, or (iv) floating and rowing on the surface of water. Arthrobots are simple to fabricate and are able to operate safely in contact with humans.
Abstract 4244: Using lysosomal immunogenic cell death to target cancer via xanthine oxidase (2022)

Abstract Lysosome-induced immunogenic cell death (LIICD) is a powerful mechanism of targeting cancer cells that kills circulating malignant cells and primes the host’s immune cells against future remission. Current immunotherapies for cancer are limited in preventing recurrence - a gap which can be bridged by training the immune system to recognize cancer neoantigens. Lysosomal leakage can be induced therapeutically to traffic antigens from dying cells to dendritic cells which can later present those tumorigenic antigens to T cells. We demonstrate that the oxidative agent native bovine xanthine oxidase can induce early markers of lysosome-induced immunogenic cell death in an in vitro human cancer cell line (CCL2). Specifically, we measured overall cell death, as well as surface-expressed calreticulin, extracellular ATP release, and HMGB1 production. These markers are consensus indicators of ICD. Flow cytometry, luminescence assays, and ELISA were used respectively to quantify biomarker levels between treated versus untreated cells. We also included a positive control group of cells dosed with doxorubicin (a known inducer of LIICD). We looked at each marker at various time points after cancer cells were treated with xanthine oxidase, doxorubicin, and an untreated group. Upregulated biomarkers after treatment with the protein indicate an immunogenic response. Further, we used confocal imaging to show lysosomal membrane permeabilization after treatment with Native Bovine Xanthine Oxidase using Lucifer Yellow staining. We thus show the potential for this protein to induce an anticancer effect paired with an adaptive immune response against tumor cells. Our research in human cell lines here provides evidence for the success of the same therapeutic method in patients and serve as the gateway to developing a new treatment approach against breast cancer. Citation Format: Iulianna Taritsa, Eric Fossel, Kuldeep Neote. Using lysosomal immunogenic cell death to target cancer via xanthine oxidase [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 4244.
Letter to the Editor: The Functional Outcome of Hip Resurfacing and Large-head THA is the Same (2010)

Dr. Lavigne and his coauthors [2] performed a PRCT to address a question that needs to be answered urgently: can resurfacing provide superior function over conventional hip replacement for active patients that might make the reported higher risk of reoperation worthwhile? However, their power calculation was based on the premise that anything less than a 12% increase in normal walking speed would not be significant on the grounds that an earlier study had found such a difference between patients who had hip resurfacing and those with an arthritic hip [3]. This position is obtuse. The difference between the comfortable walking speeds of fit men in their 30s and 70s is only 0.13 m/second or less than 10% [1]. In fast walking, as measured by Lavigne et al. [2], which might be considered a surrogate for top speed, the patients who had hip resurfacing walked 0.9 m/second, or 5% faster than the patients who had total hip replacements, however the study was not powered to detect this difference. Others have noted that patients who had hip resurfacing have higher UCLA scores than patients who had hip replacements [4], suggesting that at higher levels of activity, the presence of a normal femoral neck and head might confer some advantage. This costly and well-conducted trial has contributed a detailed methodology to the literature. However, by setting a bar of 12% superiority, the authors appear determined to avoid finding a 10% significance, a level that medical interventions use across many specialities. Even a 5% performance improvement in any sport would constitute overwhelming superiority. Such a type II error should be acknowledged in a trial which genuinely is seeking to establish superiority of an intervention.
Superparamagnetic [sic] nanofibers by electrospinning (2016)

Magnetically ultra-soft and anisotropic electrospun fibre mats.
Metamaterials with custom emissivity polarization in the near-infrared (2013)

Metamaterials have been previously studied for their ability to tailor the dispersive infrared (IR) emissivity of a surface. Here, we investigate metamaterial coatings based on an electromagnetic band-gap surface for use as near-IR emitters with custom polarization selectivity. A genetic algorithm is successfully employed to optimize the metamaterial structures to exhibit custom linear, circular, and elliptical polarization. A study is also conducted on a bi-anisotropic slab, showing that anisotropic chirality is required in the metamaterial structure in order to achieve circular or elliptical emissivity polarization.
DEVELOPMENT OF LABORATORY AND POINT OF CARE DETECTION PLATFORMS FOR COVID-19 NEUTRALIZING ANTIBODIES AND IMMUNE STATUS (2023)

Intro: Candida auris has emerged as a serious global health threat by the Centres for Disease Control and Prevention (CDC).This has drawn attention to another multidrug-resistant species, i.e., C. vulturna , a new member of C. haemulonii complex and it is closely related to C. auris .Methods: A total of 19 isolates (n = 19) of C. vulturna had been isolated from blood of immunocompromised patients in Malaysian.Yeast dentification results were documented using physiological and biochemical techniques.Molecular identification of the isolates was accomplished by PCR-sequencing techniques.Phylogenetic analysis was done to investigate the genetic relatedness of C. vulturna to other Candida species.Antifungal susceptibility test was performed using commercialised Vitek system against various antifungal agents.The minimum inhibitory concentrations (MICs) and interpretive criteria for antifungals were following CLSI (2017).Findings: Out of 19 cases of C. vulturna infections, 47% (n = 9) of the cases were reported from Sabah, followed by three cases from Klang Valley, two cases from Sarawak and five cases from other states.All isolates matched 99.7 to 100% similarity to the reference strain of C. vulturna 11-1170.Isolates of C. vulturna were resistant to amphotericin B, fluconazole and voriconazole.They were moderately resistant to itraconazole.In contrast, C. vulturna isolates showed susceptible to anidulafungin and caspofungin.Discussion: Generally, C. vulturna was isolated from all over Malaysian states, especially in Sabah.PCR-sequencing enable for an accurate identification of the species.Similarly with C. auris, C. vulturna displayed multi-drug resistant to azoles and amphotericin B. Conclusion:Our results indicate that, C. vulturna has emerge as an important opportunistic human pathogen and require more attention as C. auris , due to the difficulty to identify and resistance to antifungals.Their ability to transmitted within a healthcare facility and may cause healthcare associated outbreaks should be monitored.
Proceedings, 2000 International Conference on Parallel Processing, 21-24 August 2000 Toronto, Canada (2000)

Contains 63 papers from the August 2000 conference divided into 22 sessions. Two major topics are wireless networks and heterogeneous computing. Among the other topics are multilayer VLSI layout for interconnection networks, a network co-processor-based approach to scalable media streaming in server
Generation of intense pulsed electron beams by the pseudospark discharge (1989)

A low-pressure gas discharge is presented as a source of intense pulsed electron beams. The pseudospark discharge emits a short-duration pinched electron beam during the breakdown phase. At voltages of typically 20 kV, approximately 10-20% of the total discharge current appears as the electron-beam current of typically 20 ns in duration. According to the breakdown voltage in the beam, a power density on the order of 10/sup 9/ W/cm/sup 2/ is reached. Thus, this electron beam turns out to be a good tool for material processing, comparable to pulsed high-power lasers. Besides the drilling of holes into metals and insulators, an interesting application is the production of high-temperature superconducting thing YBa/sub 2/Cu/sub 3/O/sub 7-x/ films. The electron beam is used to evaporate material from a stoichiometric 1-2-3 target. Experimental results concerning the propagation behavior in neutral gas, the electron energy distribution, and the interaction with matter are reported.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Lab of Things (2015)

column Share on Lab of Things: Building a Research Platform for Connected Devices in the Home and Beyond Authors: Arjmand Samuel Microsoft Research Microsoft ResearchView Profile , A.J. Bernheim Brush Microsoft Research Microsoft ResearchView Profile , Ratul Mahajan Microsoft Research Microsoft ResearchView Profile Authors Info & Claims GetMobile: Mobile Computing and CommunicationsVolume 18Issue 4October 2014 pp 37–40https://doi.org/10.1145/2721914.2721927Online:13 January 2015Publication History 5citation150DownloadsMetricsTotal Citations5Total Downloads150Last 12 Months6Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
<title>Application of fluorescence depolarization to dye uptake and particle sizing in silica sols</title> (1999)

We describe a new approach to particle size measurement in silica sols based on the decay of fluorescence anisotropy of a bound near infrared dye. Changes in particle size up to 4.5 nm are resolved with sub-nanometer resolution across the sol to gel transition.
ChemInform Abstract: Photoinduced Energy and Electron Transfer Processes in Rigidly Bridged Dinuclear Ru/Os Complexes (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Development of CD8+ Effector T Cells Is Differentially Regulated by IL-18 and IL-12 (1999)

We investigated the effects of IL-18 on the development of CD8+ effector T cells in DBA/2 anti-BDF1 whole spleen cell MLC and compared the results with those of IL-12. Addition of IL-18 to the MLC resulted in a twofold increase in CD8/CD4 ratios compared with the control cultures when cells were expanded in IL-2-containing medium following MLC. Purified CD8+ T cells recovered from the IL-18-stimulated MLC produced 20- to 30-fold more IFN-gamma after secondary stimulation with C57BL/6 spleen cells or anti-CD3 mAb, and exhibited strong allospecific CTL activity. Neither IL-18 nor IL-18-supplemented culture supernatants from DBA/2 anti-BDF1 MLC induced type I CD8+ effector T cells when purified CD8+ T cells were used as responder cells in primary MLC. Furthermore, CD4+ T cell depletion from the responder cells abrogated the IL-18-induced increase in secondary IFN-gamma production by CD8+ T cells, suggesting that IL-18-induced type I effector CD8+ T cell development was CD4+ T cell dependent. In marked contrast, adding IL-12 to primary MLC decreased CD8/CD4 ratios by 50% and suppressed secondary IFN-gamma production and CTL activity by CD8+ T cells regardless of concentration, whereas Th1 development was promoted by IL-12. Moreover, both IL-12 and IL-18 efficiently induced type I CD8+ effector T cells in C57BL/6 anti-BDF1 MLC. These findings show that IL-18 plays an important role in the generation of type I CD8+ effector T cells, and further suggest that functional maturation of CD8+ T cells is differentially regulated by IL-18 and IL-12.