gebhart/patrepeval huggingface dataset:
Antitumor activity of a novel small molecule agent PRLX 93936 against human tumor xenograft models (2007)

B38 PRLX 93936 was identified as a potential anti-cancer therapeutic in a synthetic lethal screen against isogenic cell lines engineered to differentially express several oncogenes including activated RasV12. Subsequent testing against a series of normal and tumor cell lines derived from tumors with dissimilar causative mutations and limited treatment options, indicated potent and selective activity against a wide variety of tumor cell lines (many with activated Ras pathway). Mass spectrometric analysis of proteins selectively pulled-down from tumor lysates by PRLX 93936 immobilized on bead surfaces led to the identification of mitochondrial outer membrane protein VDAC (Voltage Dependent Anion Channel) as a potential target. PRLX 93936 caused tumor regression in human xenograft models representing cancers such as pancreatic (PANC-1) and fibrosarcoma (HT-1080). Tumor regression was demonstrated with oral (PO), intravenous (IV), and intraperitoneal (IP) routes of administration. In vivo, PRLX 93936 produces efficacy ranging from tumor-growth inhibition to complete regression in a dose-dependent fashion. Toxicology studies with mice, rats, dogs, and monkeys indicate drug tolerance at potentially therapeutic levels based on body surface area scaling. Although its mechanism of action is still under investigation, results of pharmacodynamic studies demonstrate its promise as a novel anti-cancer drug. As a result of successful IND submission, Phase 1 clinical trials are scheduled for September 2007.
ChemInform Abstract: Identification of 3‐Enol Sulfate of Cypridina Luciferin, Cypridina Luciferyl Sulfate, in the Sea‐Firefly Cypridina (Vargula) hilgendorfii. (2014)

ChemInformVolume 45, Issue 33 Natural Products ChemInform Abstract: Identification of 3-Enol Sulfate of Cypridina Luciferin, Cypridina Luciferyl Sulfate, in the Sea-Firefly Cypridina (Vargula) hilgendorfii. Mitsuhiro Nakamura, Mitsuhiro Nakamura Yokohama Res. Cent., JNC Corp., Yokohama 236, JapanSearch for more papers by this authorTomoko Suzuki, Tomoko Suzuki Yokohama Res. Cent., JNC Corp., Yokohama 236, JapanSearch for more papers by this authorNorihiro Ishizaka, Norihiro Ishizaka Yokohama Res. Cent., JNC Corp., Yokohama 236, JapanSearch for more papers by this authorJun-ichi Sato, Jun-ichi Sato Yokohama Res. Cent., JNC Corp., Yokohama 236, JapanSearch for more papers by this authorSatoshi Inouye, Satoshi Inouye Yokohama Res. Cent., JNC Corp., Yokohama 236, JapanSearch for more papers by this author Mitsuhiro Nakamura, Mitsuhiro Nakamura Yokohama Res. Cent., JNC Corp., Yokohama 236, JapanSearch for more papers by this authorTomoko Suzuki, Tomoko Suzuki Yokohama Res. Cent., JNC Corp., Yokohama 236, JapanSearch for more papers by this authorNorihiro Ishizaka, Norihiro Ishizaka Yokohama Res. Cent., JNC Corp., Yokohama 236, JapanSearch for more papers by this authorJun-ichi Sato, Jun-ichi Sato Yokohama Res. Cent., JNC Corp., Yokohama 236, JapanSearch for more papers by this authorSatoshi Inouye, Satoshi Inouye Yokohama Res. Cent., JNC Corp., Yokohama 236, JapanSearch for more papers by this author First published: 28 July 2014 https://doi.org/10.1002/chin.201433230Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume45, Issue33August 19, 2014 RelatedInformation
Development of High-Throughput Screening Assays for Inhibitors of ETS Transcription Factors (2017)

Abstract ETS transcription factors from the ERG and ETV1/4/5 subfamilies are overexpressed in the majority of prostate cancer patients and contribute to disease progression. Here, we develop two in vitro assays for the interaction of ETS transcription factors with DNA that are amenable for high throughput screening. Using ETS1 as a model, these assays were applied to screen 110 compounds derived from a high-throughput virtual screen. We find that the use of lower affinity DNA-binding sequences, similar to those which ERG and ETV1 bind to in prostate cells, allowed for higher inhibition from many of these test compounds. Further pilot experiments demonstrated that the in vitro assays are robust for ERG, ETV1, and ETV5, three of the ETS transcription factors that are overexpressed in prostate cancer.
Stability and Performance of Ultrafiltration Membranes in Aqueous Ethanol (2003)

The stability of several polymeric ultrafiltration membranes in aqueous ethanol was evaluated with an ethanol-soluble protein. Concentration polarization effects were observed at concentrations of 5–150 g/L of the protein, with flux becoming independent of pressure above 100–200 kPa. The data followed the film theory, resulting in a C g value of 340 g/L with the model protein. Protein rejections for the selected membranes were 80–95%. However, even with prior conditioning, some membranes (polysulfone, polyacrylonitrile, and cellulosic) that initially appeared to give good performance and stability failed over a period of 10 weeks, resulting in an increase in flux or decrease in protein rejection. Polysulfone hollow fibers gave good initial performance but degraded in less than 24 hours of cumulative use.
Placebo effect after visual restitution training: no eye-tracking controlled perimetric improvement after visual border stimulation in late subacute and chronic visual field defects after stroke (2023)

Bright-light detection RT at the blind-field border solely induced a placebo effect and did not lead to training-induced neuroplasticity in the visual cortex of the type needed to ameliorate the visual field size of stroke patients.
Non-intrusive OSNR measurement of polarization-multiplexed signals with spectral shaping and subject to fiber non-linearity with minimum channel spacing of 375GHz (2016)

A non-intrusive OSNR measurement technique relying on the detailed spectral comparison of an optical signal with its "noise-free" spectrum is described, including mathematical basis, validity conditions and algorithmic steps. The technique's performance is experimentally demonstrated with 100G PM-QPSK and 200G PM-16QAM signals subject to fiber non-linearity induced by 100G PM-QPSK and 10G NRZ-OOK neighbors. The OSNR measurement performance is also demonstrated when root-raised cosine spectral shaping is applied to the signals, with channel spacings of 50GHz and 37.5GHz. Experimental results for OSNR levels up to 30dB and launch powers up to 3dB above the optimum BER launch conditions are shown for different system and signal configurations.
Copyright page (2011)

Copyright and Reprint Permission: Abstracting is permitted with credit to the source. Libraries are permitted to photocopy beyond the limit of U.S. copyright law for private use of patrons those articles in this volume that carry a code at the bottom of the first page, provided the per-copy fee indicated in the code is paid through Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923. For other copying, reprint or republication permission, write to IEEE Copyrights Manager, IEEE Operations Center, 445 Hoes Lane, Piscataway, NJ 08854. All rights reserved. Copyright (c) 2011 by IEEE. IEEE Catalog Number: CFP11817-ART. ISBN: 978-1-61284-878-5
Identification of the Key Residues Responsible for the Assembly of Selenodeiodinases (2006)

Type I deiodinase is the best characterized member of a small family of selenoenzymes catalyzing the bioactivation and disposal of thyroid hormone. This enzyme is an integral membrane protein composed of two 27-kDa subunits that assemble into a functional enzyme after translation using a highly conserved sequence of 16 amino acids in the C-terminal half of the polypeptide, (148)DFLXXYIXEAHXXDGW(163). In this study, we used alanine scanning mutagenesis to identify the key residues in this domain required for holoenzyme assembly. Overexpression of sequential alanine-substituted mutants of a dimerization domain-green fluorescent protein fusion showed that sequence (152)IYI(154) was required for type I enzyme assembly and that a catalytically active monomer was generated by a single I152A substitution. Overexpression of the sequential alanine-substituted dimerization domain mutants in type II selenodeiodinase-expressing cells showed that five residues ((153)FLIVY(157)) at the beginning and three residues ((164)SDG(166)) at the end of this region were required for the assembly of the type II enzyme. In vitro binding analysis revealed a free energy of association of -60 +/- 5 kJ/mol for the noncovalent interaction between dimerization domain monomers. These data identify and characterize the essential residues in the dimerization domain that are responsible for the post-translational assembly of selenodeiodinases.
Persistent Chronic Inflammation and Infection by Chikungunya Arthritogenic Alphavirus in Spite of a Robust Host Immune Response (2010)

Alphaviruses, including Chikungunya virus (CHIKV), produce a transient illness in humans, but severe forms leading to chronic incapacitating arthralgia/arthritis have been reported by mechanisms largely ill-characterized. The pathogenesis of CHIKV was addressed in a prospective cohort study of 49 hospitalized patients from Reunion Island subsequently categorized into two distinct groups at 12 mo postinfection. Comprehensive analyses of the clinical and immunological parameters throughout the disease course were analyzed in either the "recovered" or the "chronic" groups to identify prognostic markers of arthritis-like pathology after CHIKV disease. We found that the chronic group consisted mainly of more elderly patients (>60 y) and with much higher viral loads (up to 10(10) viruses per milliliter of blood) during the acute phase. Remarkably, a rapid innate immune antiviral response was demonstrated by robust dendritic/NK/CD4/CD8 cell activation and accompanied by a rather weak Th1/Th2 cytokine response in both groups. Interestingly, the antiviral immune response witnessed by high levels of IFN-alpha mRNA in PBMCs and circulating IL-12 persisted for months only in the chronic group. CHIKV (RNA and proteins) was found in perivascular synovial macrophages in one chronic patient 18 mo postinfection surrounded by infiltrating NK and T cells (CD4(++) but rare cytotoxic CD8). Fibroblast hyperplasia, strong angiogenesis, tissue lesions given the high levels of matrix metalloproteinase 2, and acute cell death [high cleaved poly(ADP-ribose) polymerase staining] were observed in the injured synovial tissue. These observed cellular and molecular events may contribute to chronic arthralgia/arthritis targeted by methotrexate used empirically for effective treatment but with immunosuppressive function in a context of viral persistence.
EACELEB: An East Asian Language Speaking Celebrity Dataset for Speaker Recognition (2022)

Large datasets are very useful for training speaker recognition systems, and various research groups have constructed several over the years. Voxceleb is a large dataset for speaker recognition that is extracted from Youtube videos. This paper presents an audio-visual method for acquiring audio data from Youtube given the speaker's name as input. The system follows a pipeline similar to that of the Voxceleb data acquisition method. However, our work focuses on fast data acquisition by using face-tracking in subsequent frames once a face has been detected -- this is preferable over face detection for every frame considering its computational cost. We show that applying audio diarization to our data after acquiring it can yield equal error rates comparable to Voxceleb. A secondary set of experiments showed that we could further decrease the error rate by fine-tuning a pre-trained x-vector system with the acquired data. Like Voxceleb, the work here focuses primarily on developing audio for celebrities. However, unlike Voxceleb, our target audio data is from celebrities in East Asian countries. Finally, we set up a speaker verification task to evaluate the accuracy of our acquired data. After diarization and fine-tuning, we achieved an equal error rate of approximately 4\% across our entire dataset.
Synthesis of a Highly Electron-Deficient, Water-Stable, Large Ionic Box: Multielectron Accumulation and Proton Conductivity (2022)

π-acidic boxes exhibiting electron reservoir and proton conduction are unprecedented because of their instability in water. We present the synthesis of one of the strongest electron-deficient ionic boxes showing e<sup>-</sup> uptake as well as proton conductivity. Two large anions fit in the box to form anion-π interactions and form infinite anion-solvent wires. The box with NO<sub>3</sub><sup>-</sup>···water wires confers high proton conductivity and presents the first example that manifests redox and ionic functionality in an organic electron-deficient macrocycle.
<title>Detection of trace levels of mercury in aqueous systems via a fiber optic probe</title> (1994)

Currently there is a great deal of interest in the development and use of fiber optic chemical sensors for characterization of contaminated waste sites. Development of remote, in-situ sensors for rapid determination of the presence, and concentration of hazardous materials will significantly reduce site remediation costs. The state-of-the-art technology for assessing site contamination is the cone penetrometer system. This system consists of a 2-1/2 ton truck, a hydraulic ram, and a steel tube. The steel tube, which is generally 1-3/4 inches OD and 1 inch ID, has a sharp tip on one end. To begin site characterization the penetrometer tube is placed into the hydraulic ram then the tube is pushed into the ground. Sensors are mounted in the penetrometer tube to measure contaminants in the surrounding soil and ground water. This system has several distinct advantages over conventional drilling techniques. Additionally, site characterization can be performed much quicker than standard drilling techniques. Fiber optic chemical sensors are readily applicable towards use in cone penetrometer systems since they are small in size and can report real time, in-situ results. Some fiber optic chemical sensors have been deployed and tested in the cone penetrometer system.
Commercial law (2013)

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Cytoplasmic Proteins Interact with a Translational Control Element in the Protein-Coding Region of Proopiomelanocortin mRNA (1999)

Previous studies have indicated that proopiomelanocortin (POMC) is translationally regulated. We proposed that the regulatory mechanism involves an interaction between trans-acting protein factors and a cis-acting stem-loop structure in the coding region of POMC mRNA. Functional interactions were tested by examining the translation of mouse POMC mRNA in a rabbit reticulocyte system. Specific binding was demonstrated with ultraviolet-crosslinking and RNA gel mobility shift assays. The evidence presented supports our hypothesis that the translational regulation of POMC gene expression involves recognition of the stem-loop by RNA-binding proteins. Furthermore, POMC stem-loop RNA-binding proteins specifically recognized a predicted stem-loop found in the coding region of corticotropin-releasing hormone, suggesting a novel mechanism of gene regulation that may extend to other neuropeptides as well.
Furan synthesis of reaction of .alpha.-hydroxy ketones with .beta.-ethoxyvinyltriphenylphosphonium salts (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFuran synthesis of reaction of .alpha.-hydroxy ketones with .beta.-ethoxyvinyltriphenylphosphonium saltsMichael E. Garst and Thomas A. SpencerCite this: J. Org. Chem. 1974, 39, 4, 584–585Publication Date (Print):February 1, 1974Publication History Published online1 May 2002Published inissue 1 February 1974https://pubs.acs.org/doi/10.1021/jo00918a044https://doi.org/10.1021/jo00918a044research-articleACS PublicationsRequest reuse permissionsArticle Views241Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Speaker turn segmentation based on between-channel differences (2004)

Multichannel recordings of meetings provide information on speaker locations in the timing and level differences between microphones. We have been experimenting with cross-correlation and energy differences as features to identify and segment speaker turns. In particular, we have used LPC whitening, spectral-domain cross-correlation, and dynamic programming to sharpen and disambiguate timing differences between mic channels that may be dominated by noise and reverberation. These cues are classified into individual speakers using spectral clustering (i.e. defined by the top eignenvectors of a similarity matrix). We show that this technique is largely robust to precise details of mic positioning etc., and can be used with some success with data collected from a number of different setups, as provided by the NIST 2004 Meetings evaluation.
Material dependence of switching speed of atomic switches made from silver sulfide and from copper sulfide (2007)

We developed an atomic switch consisting of an ionic and electronic mixed conductor electrode and a counter metal electrode, having a space of about 1 nm between them. Formation and annihilation of a conductive atomic bridge is controlled using a solid electrochemical reaction, which is caused by applying a certain bias voltage between the electrodes. In this study, we measured the switching time of atomic switches made of silver sulfide and copper sulfide. The switching times were different, and this difference can be attributed to the different activation energies and chemical potentials of the materials.
Proof of Concept in a Case Study of Glioblastoma Multiforme Successfully Treated with IV Quercetin in Combination with Leading Edge Gamma Knife and Standard Treatments (2018)

The Stupp protocol has become standard of care for the treatment of glioblastoma (GBM) (since its publication in 2005) and has led to some limited survival improvements. This protocol, consists of radiotherapy and concomitant chemotherapy with temozolomide, an alkylating agent. Temozolomide + radiation, compared to radiation alone had added in average 3 months additional life span, 16 percent improved survival at 2 years. That said since 2005, the standard of care has not changed in regards to the treatment of early diagnosed aggressive or multifocal GBM, and unfortunately the expected survival is still poor with 75 percent of patients dying in less than 2 years and average survival of 15 months. In patients with multifocal tumors (such as the case below) the average survival is even worse with less than 4 months at her age [1]. Here we present a case study of a patient with advanced multifocal, and rapidly progressing Glioblastoma Multiforme treated with STUPP protocol in combination with IV Quercetin. The patient experienced improved quality of life and response, compared to historical data. It is our recommendation to investigate such combinational approach in patients with Glioblastoma, as in our case it proved to be safe and effective with improved quality of life and performance as well as clinical response and survival.
Data from A Single Nucleotide Change in the Mouse Genome Accelerates Breast Cancer Progression (2023)

&lt;div&gt;Abstract&lt;p&gt;In the growth factor receptor gene &lt;i&gt;FGFR4&lt;/i&gt; the presence of the common single nucleotide polymorphism Arg388 has been associated with progression of various types of cancer including breast cancer. However, a causative relationship is not readily assigned due to genetic heterogeneity in different patient cohorts. To address this issue, we compared the effects of this allele on malignant progression in the &lt;i&gt;WAP-TGFα&lt;/i&gt; transgenic mouse model of breast cancer. A knock-in strain was generated to introduce an analogous Arg385 allele into the murine &lt;i&gt;FGFR4&lt;/i&gt; gene. Mouse embryonic fibroblasts derived from this strain displayed accelerated cell transformation, with transformed cells exhibiting greater motility and invasive behavior. In the &lt;i&gt;in vivo&lt;/i&gt; context of TGFα-induced mammary carcinogenesis, tumor development and progression was significantly advanced in tumor mass, size, and onset of pulmonary metastases. Our findings definitively identify the &lt;i&gt;FGFR4 Arg388&lt;/i&gt; allele as a functional prognostic marker for breast cancer progression. Cancer Res; 70(2); 802–12&lt;/p&gt;&lt;/div&gt;
Intelligent container reallocation at Microsoft 365 (2021)

The use of containers in microservices has gained popularity as it facilitates agile development, resource governance, and software maintenance. Container reallocation aims to achieve workload balance via reallocating containers over physical machines. It affects the overall performance of microservice-based systems. However, container scheduling and reallocation remain an open issue due to their complexity in real-world scenarios. In this paper, we propose a novel Multi-Phase Local Search (MPLS) algorithm to optimize container reallocation. The experimental results show that our optimization algorithm outperforms state-of-the-art methods. In practice, it has been successfully applied to Microsoft 365 system to mitigate hotspot machines and balance workloads across the entire system.
Advantage of Increasing the Number of Airgap Surfaces in Synchronous Linear Actuators (2015)

Abstract. This paper presents an realistic comparison of several electromagnetic architectures for high force density actuators. Firstly a simple classification of synchronous actuators is presented. Four equivalent architectures are chosen and modelized by saturable reluctance schemes. For each size and each architecture, dimensions are optimized in order to maximize the force-volume ratio. This optimization is done with fixed mecanical airgap. A simple thermical model is used. Results shows that the optimal number of airgaps increase with the dimensions. Moreover, Global coil architecture performances increase faster than other architectures. Several examples of global coil multiairgaps actuators are presented in order to illustrated the theoretical result.