gebhart/patrepeval huggingface dataset:
Orchestrating QoS-based Connectivity Services in a Multi-Operator Sandbox (2019)

One of the main features of 5G networks is the coordinated orchestration of both information technology (IT) and connectivity resources. This enables the deployment of a flexible and programmable architecture able to provision end-to-end services with different (and sometimes quite) stringent quality of service (QoS) constraints. In this paradigm, service orchestration may take place over single or multiple administrative domains. The 5G Exchange (5GEx) project, building on the software-defined network and the network function virtualization (NFV) concepts, targets the design and the implementation of a multi-domain orchestrator (MdO) prototype for the automatic provisioning of network service across multiple administrative domains. This paper presents an architectural solution, designed and implemented in the context of the 5GEx MdO prototype, that can be used to establish end-to-end connectivity tunnels with QoS constraints (i.e., bandwidth and/or end-to-end delay) connecting virtualized network functions deployed in remote data centers controlled by different providers by means of an innovative stateful backward recursive path-computation-element-based computation procedure. The proposed solution has been experimentally validated in terms of scalability, reliability, and end-to-end workflow proof-of-concept. Results show how the designed solution permits the automatic establishment of QoS-based end-to-end tunnels spanning across multi-technology and multi-operator network domains. The orchestration scheme does not present scalability issues for either the advertisement of resources or for the provisioning of connectivity services. Moreover, no issues have been identified from the reliability point of view.
On-Board Calibration of Spark Timing by Extremum Seeking for Flex-Fuel Engines (2013)

An extremum-seeking controller is developed to cope with the calibration complexity for modern internal combustion engines capable of operating with different blends of ethanol and gasoline. The optimization scheme adapts the spark timing such that the fuel efficiency, estimated from in-cylinder pressure data, is maximized on-board a vehicle when driving with small load variations. Experiments, performed in a four-cylinder 2 L engine, demonstrate that the developed controller successfully manages to operate the engine close to the maximum fuel efficiency for different fuel blends, even under mild transient load conditions.
Variable Selection for Confounder Control, Flexible Modeling and Collaborative Targeted Minimum Loss-Based Estimation in Causal Inference (2015)

This paper investigates the appropriateness of the integration of flexible propensity score modeling (nonparametric or machine learning approaches) in semiparametric models for the estimation of a causal quantity, such as the mean outcome under treatment. We begin with an overview of some of the issues involved in knowledge-based and statistical variable selection in causal inference and the potential pitfalls of automated selection based on the fit of the propensity score. Using a simple example, we directly show the consequences of adjusting for pure causes of the exposure when using inverse probability of treatment weighting (IPTW). Such variables are likely to be selected when using a naive approach to model selection for the propensity score. We describe how the method of Collaborative Targeted minimum loss-based estimation (C-TMLE; van der Laan and Gruber, 2010 [27]) capitalizes on the collaborative double robustness property of semiparametric efficient estimators to select covariates for the propensity score based on the error in the conditional outcome model. Finally, we compare several approaches to automated variable selection in low- and high-dimensional settings through a simulation study. From this simulation study, we conclude that using IPTW with flexible prediction for the propensity score can result in inferior estimation, while Targeted minimum loss-based estimation and C-TMLE may benefit from flexible prediction and remain robust to the presence of variables that are highly correlated with treatment. However, in our study, standard influence function-based methods for the variance underestimated the standard errors, resulting in poor coverage under certain data-generating scenarios.
Emerging immunosuppressive drugs in myelodysplastic syndromes (2012)

Agents with the potential to induce early, durable hematologic remissions are needed and many new immunosuppressive agents are available for investigation. An immune-mediated mechanism is likely to contribute to MDS early after diagnosis. New approaches that interfere with inflammatory pathways in the bone marrow microenvironment may move closer toward sustained disease control in MDS.
Apparatus for cooling an electric machine (2023)

Provided is an apparatus, for example, for use with a rotating electric machine, that includes a housing. The housing can include a housing main portion and a housing end portion. The housing main portion can be configured to be disposed proximal to a body portion of a stator section of an electric machine. The housing main portion can define a main fluid channel that is configured to conduct fluid therethrough. The housing end portion can receive fluid from said main fluid channel and direct fluid into contact with a winding end portion of a conductive winding of the stator section.
MEMS analogous micro-patterning of thermotropic nematic liquid crystalline elastomer films using a fluorinated photoresist and a hard mask process (2017)

LCE films can be patterned in the micrometer range with standard MEMS techniques.
Piezoelectric Multilayer Ceramic/Polymer Composite Transducer with 2–2 Connectivity (2006)

A multilayer piezoelectric ceramic/polymer composite with 2–2 connectivity was fabricated by thermoplastic green machining after co‐extrusion. The multilayer ceramic body was composed of piezoelectrically active lead zirconate titanate (PZN)–lead zinc niobate (PZN)‐lead zirconate titanate (PZT) layers and electrically conducting PZN–PZT/Ag layers. After co‐extruding the thermoplastic body, which consisted of five piezoelectric layers interspersed with four conducting layers, it was computer numeric‐controlled machined to create periodic channels within it. Following binder burnout and sintering, an 18 vol% array of 190 μm thin PZT slabs with a channel size of 880 μm was fabricated. The channels were filled with epoxy in order to fabricate a PZN–PZT/epoxy composite with 2–2 connectivity. The piezoelectric coefficient (effective d 33 ) and hydrostatic figure of merit ( d h × g h ) of the PZN–PZT/epoxy composite were 1200 pC/N and 20 130 × 10 −15 m 2 /N, respectively. These excellent piezoelectric characteristics as well as the relatively simple fabrication procedure will contribute in widening the application range of the piezoelectric transducers.
Pronto: Rapid Augmented Reality Video Prototyping Using Sketches and Enaction (2020)

Designers have limited tools to prototype AR experiences rapidly. Can lightweight, immediate tools let designers prototype dynamic AR interactions while capturing the nuances of a 3D experience? We interviewed three AR experts and identified several recurring issues in AR design: creating and positioning 3D assets, handling the changing user position, and orchestrating multiple animations. We introduce PROJECT PRONTO, a tablet-based video prototyping system that combines 2D video with 3D manipulation. PRONTO supports four intertwined activities: capturing 3D spatial information alongside a video scenario, positioning and sketching 2D drawings in a 3D world, and enacting animations with physical interactions. An observational study with professional designers shows that participants can use PRONTO to prototype diverse AR experiences. All participants performed two tasks: replicating a sample non-trivial AR experience and prototyping their open-ended designs. All participants completed the replication task and found PRONTO easy to use. Most participants found that PRONTO encourages more exploration of designs than their current practices.
Pattern Recognition Method for Metric Space by Four Points Embedding. (1998)

: In solving pattern recognition problem in the Euclidean space, prototypes representing classes are defined. On the other hand in the metric space, Nearest Neighbor method and K-Nearest Neighbor method are frequently used without defining any prototypes. In this paper, we propose a new pattern recognition method for the metric space that can use prototypes which are the centroid of any three patterns in a class. This method is based on the theorem that four points of any metric space can be embedded into the Euclidean space by an appropriate metric transform. Keywords: metric space, Nearest Neighbor, embedding, pattern recognition 1 Introduction In pattern recognition research, patterns are often represented as points in N-dimensional vector space in which the Euclidean distance is used as a similarity metric. This space is called the Euclidean space. This representation is very convenient because the Euclidean space offers powerful analytical tools for data analysis which is not av...
The ermC leader peptide: amino acid alterations leading to differential efficiency of induction by macrolide-lincosamide-streptogramin B antibiotics (1990)

The inducibility of ermC by erythromycin, megalomicin, and celesticetin was tested with both wild-type ermC and several regulatory mutants altered in the 19-amino-acid-residue leader peptide, MGIFSIFVISTVHYQP NKK. In the model test system that was used, the ErmC methylase was translationally fused to beta-galactosidase. Mutational alterations that mapped in the interval encoding Phe-4 through Ile-9 of the leader peptide not only affected induction by individual antibiotics, but did so differentially. The subset of mutations that affected inducibility by the two macrolides erythromycin and megalomicin overlapped and were distinct from the subset of mutations that affected induction by celesticetin. These studies provide a model system for experimentally varying the relative efficiencies with which different antibiotics induce the expression of ermC. The possibility that antibiotics with inducing activity interact directly with the nascent leader peptide was tested by using a chemically synthesized decapeptide, MGIFSIFVIS--, attached at its C-terminus to a solid-phase support. This peptide, however, failed to bind erythromycin in vitro.
Multidimensional Included and Excluded Sums (2021)

This paper presents algorithms for the included-sums and excluded-sums problems used by scientific computing applications such as the fast multipole method. These problems are defined in terms of a $d$-dimensional array of $N$ elements and a binary associative operator~$\oplus$ on the elements. The included-sum problem requires that the elements within overlapping boxes cornered at each element within the array be reduced using $\oplus$. The excluded-sum problem reduces the elements outside each box. The weak versions of these problems assume that the operator $\oplus$ has an inverse $\ominus$, whereas the strong versions do not require this assumption. In addition to studying existing algorithms to solve these problems, we introduce three new algorithms. The bidirectional box-sum (BDBS) algorithm solves the strong included-sums problem in $Θ(d N)$ time, asymptotically beating the classical summed-area table (SAT) algorithm, which runs in $Θ(2^d N)$ and which only solves the weak version of the problem. Empirically, the BDBS algorithm outperforms the SAT algorithm in higher dimensions by up to $17.1\times$. The \defn{box-complement} algorithm can solve the strong excluded-sums problem in $Θ(d N)$ time, asymptotically beating the state-of-the-art corners algorithm by Demaine et al., which runs in $Ω(2^d N)$ time. In 3 dimensions the box-complement algorithm empirically outperforms the corners algorithm by about $1.4\times$ given similar amounts of space. The weak excluded-sums problem can be solved in $Θ(d N)$ time by the bidirectional box-sum complement (BDBSC) algorithm, which is a trivial extension of the BDBS algorithm. Given an operator inverse $\ominus$, BDBSC can beat box-complement by up to a factor of $4$.
Graphene-zinc Oxide Based Nanomaterials for Gas Sensing Devices (2016)

Herein, we report the preparation of a hybrid material by combination of modified graphene and ZnO. The morphological and compositional analyses of the obtained material have been performed by means of scanning electron microscopy and energy dispersive X-ray analysis. The functional properties of the prepared structures have been investigated for their application in gas sensor devices. The gas sensing performance of the hybrid material show that the structure can be used for fabrication of chemical sensors, as well as in electronic nose technology.
Spontaneous resolution of a superior mesenteric vein thrombosis after laparoscopic nissen fundoplication. (2002)

A previously fit 37-year-old man developed superior mesenteric venous thrombosis after undergoing a laparoscopic Nissen fundoplication. Despite receiving thrombo-embolic prophylaxis on postoperative day 16, he presented with a gradual onset of vague, but severe, umbilical and epigastric pains. Laboratory tests, abdominal ultrasound scan and gastroscopy were all unremarkable. Contrast enhanced abdominal spiral computerised tomography (CT) revealed a partial occlusion of the superior mesenteric and portal vein due to a thrombus; abnormal flow was confirmed on colour Doppler ultrasound. A predisposing hyper-coagulable condition was excluded. The patient responded rapidly to expectant management and a repeat spiral CT scan, 3 weeks after the initial presentation, demonstrated complete re-canalisation of the vessel. Although rare, superior mesenteric venous thrombosis is probably underdiagnosed due to the vague nature of the symptoms, the lack of clinical signs, a low index of suspicion on the part of the clinician, and then subsequent failure to request the optimal investigation--namely contrast enhanced abdominal spiral CT scan. We discuss the possible mechanisms by which laparoscopic surgery may increase the risks of developing superior mesenteric venous thrombosis, the pitfalls in diagnosis and treatment options.
Zinc Oxide-Multi Walled Carbon Nanotubes Nanocomposites for Carbon Monoxide Gas Sensor Application (2015)

Zinc oxide (ZnO)/multi walled carbon nanotubes (MWCNTs) composites based sensors with different ZnO concentrations were fabricated to improve carbon monoxide (CO) gas sensing properties in comparison to the sensors based on bare MWCNTs. To study the structure, morphology and elemental composition of the resultant products, X-ray diffraction (XRD), Field emission scanning electron microscopy (FESEM) and Energy dispersive X-ray spectroscopy (EDS) were carried out. It has been observed that as the concentration of ZnO is increased more and more ZnO nanoparticles in the form of nodes get attached to MWCNTs resulting the reduction in average diameter of MWCNTs. The typical response of ZnO/MWCNTs composites based gas sensors for different CO concentrations (40, 100, 140 and 200 ppm) was studied by using very advanced sensing setup attached to I-V measurement system. Different sensing parameters such as: resistive response, sensitivity and response time were estimated at room temperature for all the fabricated sensors. The results indicated that the sensor based on nanocomposite which has 30 mg ZnO dispersed on 20 mg MWCNTs showing highest sensitivity and fastest response. All the sensors showed response times ranging from 8 to 23 seconds. The sensing mechanism behind the sensors based on ZnO/MWCNTs nanocomposites for CO gas at room temperature is also discussed in the present report.
Young's modulus characterisation of mesoporous titania films using Love wave sensors (2009)

International audience
[ACTH-secreting tumors. Deregulation of the proopiomelanocortin gene and alterations in processing]. (1988)

ACTH is produced by proteolysis of a polypeptide precursor, proopiomelanocortin (or POMC). Various POMC-derived peptides are cosecreted with ACTH. Analysis of the ACTH--and its "satellite" peptides--molecular forms establishes the POMC "maturation profile" in different tissues. This profile is identical in normal and tumoral pituitaries (Cushing's disease and/or Nelson's syndrome). It is often altered in non-pituitary tumors responsible for the ectopic ACTH syndrome: abnormal peptides may be generated (CLIP h beta MSH5-22) which can be detected in blood. Analysis of POMC gene transcription in pituitary tumors shows no abnormality. In some non-pituitary tumors the activation of upstream promoters up to 369 nucleotides from the normal (pituitary) transcription initiation site can be shown. In normal non-pituitary tissues a third type of transcription is observed generating a short and probably non-functional messenger RNA limited to a portion of the gene non-coding region.
Interaction of Lp(a) with Plasminogen Binding Sites on Cells (1995)

Lp(a) competes with plasminogen for binding to cells but it is not known whether this competition is due to the ability of Lp(a) to interact directly with plasminogen receptors. In the present study, we demonstrate that Lp(a) can interact directly with plasminogen binding sites on monocytoid U937 cells and endothelial cells. The interaction of Lp(a) with these sites was time dependent, specific, saturable, divalent ion independent and temperature sensitive, characteristics of plasminogen binding to these sites. The affinity of plasminogen and Lp(a) for these sites also was similar (Kd = 1-3 microM), but Lp(a) bound to fewer sites (approximately 10-fold less). Both gangliosides and cell surface proteins with carboxy-terminal lysyl residues, including enolase, a candidate plasminogen receptor, inhibited Lp(a) binding to U937 cells. Additionally, Lp(a) interacted with low affinity lipoprotein binding sites on these cells which also recognized LDL and HDL. The ability of Lp(a) to interact with sites on cells that recognize plasminogen may contribute to the pathogenetic consequences of high levels of circulating Lp(a).
Evidence of a Substantial Genetic Basis for IgG2 Levels in Families with Aggressive Periodontitis (2003)

IgG2 is elevated in localized but not in generalized aggressive periodontitis (AgP). Exposure to pathogenic bacteria is essential for disease. Immune responses are dominated by IgG2 reactive with bacterial surface carbohydrates. We used variance component analyses to assess IgG2 heritability and determine whether genes that influence IgG2 are the same genes that influence disease susceptibility. We studied 17 Caucasian and 43 African American families with two or more localized or generalized AgP-affected members (274 subjects with IgG2 measurements). Only 16% of the variance in IgG2 was attributable to age, race, and smoking. Even with the addition of localized AgP, the model still explained only 19% of IgG2 variance. By contrast, heritability of IgG2 levels was estimated to be 38% and highly significant (P = 0.0006), demonstrating a substantial genetic basis. Bi-trait variance component analyses of IgG2 and quantitative measures of AgP indicate that different genes appear to control IgG2 levels and disease susceptibility.
Atypical Hemolytic Uremic Syndrome (aHUS) and Adenosine Deaminase (ADA)-Deficient Severe Combined Immunodeficiency (SCID)—Two Diseases That Exacerbate Each Other: Case Report (2021)

Hemolytic uremic syndrome (HUS) is defined by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI). Atypical HUS (aHUS), distinguished by its etiology, is caused by uncontrolled overactivation of the alternative complement pathway. The correct diagnosis of aHUS is complex and involves various gene mutations. Severe combined immunodeficiency (SCID), characterized by severe T-cell lymphocytopenia and a lack of antigen-specific T-cell and B-cell immune responses, is of seldom occurrence. In 10-15% of pediatric patients, SCID is caused by adenosine deaminase (ADA) deficiency. The authors describe the case of a boy who suffered from both aHUS and ADA-deficient SCID. At the age of 9 months, the patient presented acute kidney injury with anuria and coagulopathy. The diagnosis of aHUS was established on the basis of alternative complement pathway deregulation and disease-associated gene mutations. Further examination revealed immune system failure and, at the age of 13 months, the ADA deficiency was confirmed by genetic tests and the boy was diagnosed with ADA-SCID. ADA SCID has recently been described as a possible triggering factor of aHUS development and progression. However, more research is required in this field. Nevertheless, it is crucial in clinical practice to be aware of these two co-existing life-threatening diseases.
The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects (1999)

Individual Rel/NF-kappaB transcription factors, although dispensable for the development and maturation of most hemopoietic cells, are critical regulators of normal immune function. Redundancy among these proteins prompted us to examine the role of Rel and RelA in hemopoiesis by using mice that lack both subunits. Because of the death of double-mutant fetuses at day 13.5 of gestation (E13.5), E12 fetal liver hemopoietic progenitors were used for in vitro cultures and for repopulating stem cell studies in lethally irradiated normal recipient mice. Most striking, Rel/RelA-deficient hemopoietic precursors failed to promote the survival of myeloablated mice. This phenotype was associated with several defects including a reduction of spleen colony-forming unit progenitors, impaired erythropoiesis, and a deregulated expansion of granulocytes. In vitro progenitor assays also revealed that Rel or RelA serves an antiapoptotic role during monocyte differentiation. Despite the combined loss of Rel and RelA leading to these hemopoietic defects, c-rel(-/-)rela(-/-) stem cells contributed to the development of all lineages in mice engrafted with double-mutant fetal liver cells and normal bone marrow cells, albeit in a reduced fashion compared with controls. Collectively, these data indicate the loss of Rel and RelA does not appear to affect pluripotent stem cells; rather, Rel and RelA serve redundant functions in regulating differentiation and survival of committed progenitors in multiple hemopoietic lineages.
ChemInform Abstract: SYNTHESIS OF 1′‐DEOXY‐1′‐FLUOROSUCROSE VIA SUCROSE SYNTHETASE MEDIATED COUPLING OF 1‐DEOXY‐1‐FLUOROFRUCTOSE WITH URIDINE DIPHOSPHATE GLUCOSE (1984)

Abstract Die durch Sucrose‐Synthetase vermittelte Kupplungsreaktion der DeSoxy‐fluorofructose (II) mit UDP‐Glucose (III) liefert die Titelverbindung (IV).
Correspondence - Characterization of the effective performance of a high-frequency annular-array-based imaging system using anechoic-pipe phantoms (2012)

A resolution integral (RI) method based on anechoic- pipe, tissue-mimicking phantoms was used to compare the detection capabilities of high-frequency imaging systems based on a single-element transducer, a state-of-the-art 256-element linear array, or a 5-element annular array. All transducers had a central frequency of 40 MHz with similar conventionally measured axial and lateral resolutions (about 50 and 85 μm, respectively). Using the RI metric, the annular array achieved the highest performance (RI = 60), followed by the linear array (RI = 47), and the single-element transducer (RI = 24). Results showed that the RI metric could be used to efficiently quantify the effective transducer performance and compare the image quality of different systems.