gebhart/patrepeval huggingface dataset:
(Invited) GaN Power Electron Devices (2011)

Recent progress in GaN-based power electron devices and advanced thermal management techniques for high performance GaN power devices are described. Recent advances in high performance GaN-based transistors are reviewed. The reduction of junction temperatures in low-pressure direct liquid cooling of GaN power devices for high-power and high-voltage applications are demonstrated using perfluorocarbon and perfluoroether as a working fluid, for the first time.
Modeling of Turbulent Diffusion Combustion Using a Combined Probability Density Function/Moment Method (Continued Report, Analysis Based on Detailed Chemical Kinetics) (2007)

The combined probability density function (PDF) /moment method which had been developed in the previous report has been evaluated in the frame of a detailed chemical kinetics. The method was implemented in the configuration of a turbulent jet diffusion flame and is evaluated through the comparison with the conventional PDF method with the detailed chemical kinetics, the flamelet model method with the flame structure on the one-step irreversible reaction and laser experiments. The present method overestimates the effect of finite reaction rate to lead to a slight deviation from the experimental values, especially in the near-field. This is caused by the ignition which is required in the PDF methods. Thus, the improvement in terms of the ignition is required. The present result is much better than the result of the conventional PDF method, reflecting the usefulness of the combined PDF/moment method.
Cyp46 (24S-Cholesterol Hydroxylase) (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Low Emission Technologies for High-Performance Handheld Outdoor Products (2000)

&lt;div class="htmlview paragraph"&gt;This paper reviews the current and new engine technologies that are suitable to be implemented in light-weight outdoor power equipment that is mostly powered by two-stroke engines. It gives insight in the concerns associated with the improvement of known technologies and highlights trends for future engine developments. Among others, the paper covers ways for the conventional scavenging improvement, catalyst development, low pressure mixture injection, direct fuel injection, stratified scavenging and also four-stroke technology. These concepts are assessed with respect to performance, cost, size and weight.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Special emphasis is laid on the research and development of a catalyst concept for high-performance two-strokes and direct fuel injection. The catalyst is one of the easiest and most effective ways for emission reduction. However, measures have to be found to overcome the severe thermal difficulties. The paper presents ways how to achieve the emission goal of 54 g/hph (e. g. for the CARB-regulation) not for the detriment of performance and thermal stability. From the technical and the performance viewpoint, the direct fuel injection is a very attractive solution. Here, the aspects of port timing, injection timing and mixture formation are discussed. With direct fuel injection, a specific power in excess of 56 kW/l can be achieved at high costs while retaining the HC emissions below 40 g/kWh at rated speed.&lt;/div&gt;
Effects of adenosine on intestinal hemodynamics, oxygen delivery, and capillary fluid exchange (1978)

Systemic arterial pressure, superior mesenteric arterial and venous pressures, blood flow, arteriovenous oxygen difference, lymph flow, and intestinal volume were monitored continuously from an autoperfused loop of cat ileum to determine the effects of locally infused adenosine on intestinal hemodynamics, oxygen consumption, and capillary fluid exchange. The results indicate that adenosine, inosine, and hypoxanthine are vasodilators in the intestinal circulation. Local infusion of adenosine significantly reduces vascular resistance, but lymph flow, lymph oncotic pressure, and lymphatic protein flux remained unchanged from control, and the intestinal volume rapidly became constant after an initial blood volume shift. Intestinal oxygen consumption decreased significantly in both autoperfused and constant flow preparations. Pretreatment with aminophylline prevented the reduction in oxygen consumption and greatly attenuated the vasodilatory effect of adenosine. The reactive hyperemic response to 60-s arterial occlusions was virtually unchanged following aminophylline treatment. Adenosine depressed oxygen utilization of mucosal and muscularis strips in vitro and caused a significant redistribution of blood flow from the mucosal-submucosal layer to the muscularis in autoperfused preparations. The results of this study indicate that adenosine significantly reduces vascular resistance and oxygen consumption, yet does not alter fluid exchange in the small intestine.
Typification of Hymenoscyphus sulphuratus (Ascomycota, Helotiales) (2014)

Hymenoscyphus sulphuratus is an uncommon species growing on conifer litter, but is typically found on Picea abies needles. As with many other historically described species, this name lacks a clearly defined type. The purpose of this note is to provide a type which covers all the features that agree with the protologue and our modern interpretation of this name
Modeling the effect of plasticizer on the viscoelastic response of crosslinked polymers using the tube-junction model (2000)

Plasticizers modify the mechanical properties of polymeric materials. The effects of plasticizers on glass transition temperatures can be most clearly observed in isochronal temperature sweep profiles of viscoelastic dynamic moduli. However, no simple mathematical models of plasticization are available to those who wish to design and employ plasticized materials in specific applications. We extend a phenomenological, molecular-level model (known as the tube–junction model) for crosslinked polymers to describe the effect of plasticizers on dynamic moduli. We show that the increase in free volume fraction due to the presence of the plasticizer can account for the shift in the glass transition in dynamic moduli. We also show that the secondary effects of plasticizers on the shape of the temperature sweep profiles can be explained in terms of increased width of the distribution of activation energies associated with intermolecular frictional forces.
Prediction that Uniaxial Tension along⟨111⟩Produces a Direct Band Gap in Germanium (2009)

We predict a new way to achieve a direct band gap in germanium, and hence optical emission in this technologically important group-IV element: tensile strain along the <111> direction in Ge nanowires. Although a symmetry-breaking band splitting lowers the conduction band at the corner of the Brillouin zone (at the L point), a direct gap of 0.34 eV in the center of the Brillouin zone (at Gamma) can still be achieved at 4.2% longitudinal strain, through an unexpectedly strong nonlinear drop in the conduction band edge at Gamma for strain along this axis. These strains are well within the experimentally demonstrated mechanical limits of single-crystal Ge (or Ge(x)Si(1-x)) nanowires, thereby opening a new material system for fundamental optical studies and applications.
Colorimetric Screening of DNA‐Binding Molecules with Gold Nanoparticle Probes (2006)

Nanoparticle assemblies interconnected with DNA can be used to screen for DNA-binding molecules colorimetrically. The melting temperature of the nanoparticle assembly increases in the presence of strong-DNA-binding molecules. Thus, the strength of the DNA binding can be determined by the change in this sharp melting transition, which is observable by a blue-to-red color change (see picture). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z504277_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
An ICI-Aware Approach for Physical-Layer Network Coding in Time-Frequency-Selective Vehicular Channels (2018)

Applying physical-layer network coding (PNC) to vehicular ad-hoc networks (VANETs) can theoretically boost the network throughput by 100%, thus partially addressing the intermittent node connectivity and short contact time issues caused by high speed vehicle motions. However, the application of OFDM modulated PNC in VANETs faces detrimental effects caused by carrier frequency offsets (CFOs) and time-frequency-selective channels. CFOs may destroy the orthogonality of OFDM subcarriers, resulting in inter-carrier interference (ICI). The CFOs of two transmitters may also be different, and cannot be removed by CFO tracking and equalization at the receiver as in conventional single-user communication even if the CFOs are known. In addition, time-frequency- selective channels due to delay and Doppler spreads are difficult to estimate and non-accurate channel estimations will increase the detection bit error rate (BER). To address the two challenges, this paper proposes an ICI-aware approach that jointly exploits pilot and data for channel estimation and data detection. Specifically, our approach jointly uses the belief propagation (BP) algorithm to mitigate the CFO/ICI effect for data detection, and the expectation maximization (EM) algorithm to accurately estimate the channels. A linear interpolation method and an ICI compensation method are simulated as benchmarks. Simulation results indicate that our approach improves the BER performance compared to the two benchmarks (more than 2 dB SNR gain in most cases), especially in the high SNR regime.
Protein Counting in Single Cancer Cells (2016)

The cell is the basic unit of biology and protein expression drives cellular function. Tracking protein expression in single cells enables the study of cellular pathways and behavior but requires methodologies sensitive enough to detect low numbers of protein molecules with a wide dynamic range to distinguish unique cells and quantify population distributions. This study presents an ultrasensitive and automated approach for quantifying phenotypic responses with single cell resolution using single molecule array (SiMoA) technology. We demonstrate how prostate specific antigen (PSA) expression varies over several orders of magnitude between single prostate cancer cells and how PSA expression shifts with genetic drift. Single cell SiMoA introduces a straightforward process that is capable of detecting both high and low protein expression levels. This technique could be useful for understanding fundamental biology and may eventually enable both earlier disease detection and targeted therapy.
Evaluation of derivative spectroscopy and multivariate calibration for problems in clinical chemistry (1989)

This thesis describes evaluations of data-processing methods for multiwavelength absorption and fluorescence derivative spectroscopy for multicomponent systems. The multiwavelength derivative spectra were processed by multiple linear regression and the Kalman filter. These approaches to multicomponent determinations are evaluated by using simulated data, measured absorption data for bilirubin and hemoglobin in a serum-like matrix and measured absorption and fluorescence data for porphyrins in diluted urine. In evaluations of these approaches for multicomponent determinations, four specific points addressed are: 1) accuracy and precision as functions of derivative order and width of smoothing window, 2) reduction of low-frequency background signals by using derivative data, 3) modeling of derivative data in the presence of unknown spectral interferents by the adaptive Kalman filter, and 4) reduction of collinearity among spectra by using derivative data. The results for derivative data of one-component systems show that with sufficient smoothing good precision and accuracy can be obtained with multiwavelength and one- and two-wavelength methods. For two-component systems, the multiwavelength method yielded more accurate computed concentrations when compared to one- and two-wavelength methods, and was easier to implement. It was shown that mixtures of bilirubin and hemoglobin and coproporphyrin and uroporphyrin in matrices with low-frequency background signals can be quantified accurately and precisely by using derivative data processed by multiple linear regression. For derivative data processed by the adaptive Kalman filter it was shown that optimum starting wavelengths occur in interferent-free regions of the spectrum; however, identification of these wavelengths in the presence of an unknown interferent was inconsistent when a criterion valid for zeroth-derivative data was used. As an example of an application of the filter, bilirubin was accurately quantified in the presence of unmodeled hemoglobin. Although all five porphyrins can be resolved from simulated data for mixtures by using multiple linear regression with fourth-derivative emission data oscillations in recorded spectra prevented the resolution of the five components. As an alternative, the presence of unmodeled porphyrins was detected and the total amount of porphyrins was determined by processing derivative data by multiple linear regression with models for two and three of the five porphyrins.
Identification of Multiple Genetic Loci Linked to the Propensity for “Behavioral Despair” in Mice (2002)

The forced swim test (FST) and tail suspension test (TST) are widely used and well established screening paradigms for antidepressants. A variety of antidepressive agents are known to reduce immobility time in both FST and TST. To identify genetic determinants of immobility duration in both tests, we analyzed 560 F2 mice from an intercross between C57BL/6 (B6) and C3H/He (C3) strains. Composite interval mapping revealed five major loci (suggestive and significant linkage) affecting immobility in the FST, and four loci for the TST. The quantitative trait loci (QTL) on chromosomes 8 and 11 overlap between the two behavioral measures. Genome-wide interaction analysis, which was developed to identify locus pairs that may contribute epistatically to a phenotype, detected two pairs of chromosomal loci for the TST. The QTL on chromosome 11 and its associated epistatic TST-QTL on chromosome X encode gamma-aminobutyric acid type A (GABA(A)) receptor subunits as candidates. Sequence and expression analyses of these genes from the two parental strains revealed a significantly lower expression of the alpha1 subunit gene in the frontal cortex of B6 mice compared to C3 mice. The present quantitative trait study should open up avenues for identifying novel molecular targets for antidepressants and unraveling the complex genetic mechanisms of depressive and anxiety disorders.
Control of HCV Replication With iMIRs, a Novel Anti-RNAi Agent (2015)

MicroRNAs (miRNAs) serve important roles in regulating various physiological activities through RNA interference (RNAi). miR-122 is an important mediator of RNAi that is known to control hepatitis C virus (HCV) replication and is being investigated in clinical trials as a target for anti-HCV therapy. In this study, we developed novel oligonucleotides containing non-nucleotide residues, termed iMIRs, and tested their abilities to inhibit miR-122 function. We compared the inhibitory effects of iMIRs and locked nucleic acids (LNAs) on HCV replication in OR6 cells, which contained full-length HCV (genotype 1b) and a luciferase reporter gene. We found that RNA-type iMIRs with bulge-type, imperfect complementarity with respect to miR-122 were 10-fold more effective than LNAs in inhibiting HCV replication and functioned in a dose-dependent manner. Moreover, iMIR treatment of OR6 cells reduced HCV replication without inducing interferon responses or cellular toxicity. Based on these results, we suggest that iMIRs can inhibit HCV replication more effectively than LNAs and are therefore promising as novel antiviral agents.
Do-it-yourself: construction of a custom cDNA macroarray platform with high sensitivity and linear range (2011)

Results presented here, demonstrate for the first time that self-made cDNA-based nylon macroarrays can produce highly reliable gene expression data with high sensitivity and covering the entire mammalian dynamic range of mRNA abundances. Starting off from minimal amounts of unamplified total RNA per sample, a reasonable amount of samples can be assayed simultaneously for the quantitative expression of hundreds of genes in an easily customisable and cost-effective manner.
DIPG-42. CAN WE CHANGE THE LANDSCAPE OF PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)? FIRST DEMONSTRATION OF CLINICAL AND RADIOGRAPHIC RESPONSE IN A PEDIATRIC H3-K27M MUTATED DIPG TO THE DRD2-ANTAGONIST ONC201 (2018)

DIPG is uniformly fatal, with a median survival of 8–9 months. We report the first pediatric patient with H3-K27M mutated DIPG treated with conventional radiotherapy and the small molecule DRD2-antagonist ONC201, with a sustained radiographic and clinical response after 8 months of therapy. A 10-year-old female presented with House-Brackmann Grade IV facial palsy and unilateral hearing loss in 2/2017. MRI demonstrated a 2.3x2.1x2.7 cm medullopontine tumor. Stereotactic biopsy confirmed H3-K27M mutated diffuse midline glioma. She completed intensity-modulated radiotherapy (59.4 Gy/33 fractions) in 5/2017. MR imaging 1-month post-radiotherapy demonstrated reduction in tumor volume (2.0x1.9x2.7 cm) with persistent Grade IV facial palsy.The patient began oral ONC201 (500 mg weekly) as a single agent in 6/2017 on an IRB-approved compassionate use protocol with MRI every 2 months. ONC201 is a first-in-class DRD2-antagonist that crosses the blood-brain barrier and has shown efficacy in high grade glioma preclinical models through a p53-independent mechanism. Tumor volume sequentially decreased by 30.6, 33.2, and 41.9% over the next three MRIs, reaching 1.8x1.7x1.9 cm at 6 months from initiation of ONC201. Ipsilateral hearing was restored and the facial palsy improved to House-Brackmann Grade I by 16 weeks after starting ONC201. The patient remains clinically improved and without adverse events 8 months after starting ONC201 and 11 months from diagnosis. This case provides initial proof-of-concept for this novel agent targeting H3-K27M DIPG. Phase II trials are ongoing to evaluate the efficacy of ONC201 in adult and pediatric patients with H3-K27M gliomas.
Epstein‐barr virus internalization and infectivity are blocked by selective protein kinase C inhibitors (1990)

Selective protein kinase C inhibitors can either block or significantly reduce Epstein-Barr virus infectivity: inhibition of transformation and decreased 3H-thymidine (3H-TdR) incorporation in human B lymphocytes infected with B95-8 EBV, as well as a significant reduction in the induction of early antigens in Raji cells superinfected by P3HRI EBV was achieved by pre-treating the cells with the inhibitors. The inhibitors do not act by blocking binding of the virus to its cellular receptor CR 2, but rather are effective in the viral internalization process. Our results suggest that protein kinase C may be involved in the process of viral entry into cells.
Steady state thermal radiation analysis between the TOPAZ-II radiator and a heat exchanger (1995)

In this study the authors investigate the feasibility and efficiency of coupling a single-pass heat exchanger to the TOPAZ-II space power system operating at steady state conditions. A first and second law analysis was performed in order to determine the optimal operating conditions which minimize the pumping power and maximize the flow exergy of the working fluid. The results of this study show that (1) the space power system is basically unaffected by the addition of this heat exchanger and (2) as much as 60% of the availability is destroyed by irreversibilities while operating at optimal flow conditions.
Structure-Based Library Design in Efficient Discovery of Novel Inhibitors (2010)

Structure-based library design employs both structure-based drug design (SBDD) and combinatorial library design. Combinatorial library design concepts have evolved over the past decade, and this chapter covers several novel aspects of structure-based library design together with successful case studies in the anti-viral drug design HCV target area. Discussions include reagent selections, diversity library designs, virtual screening, scoring/ranking, and post-docking pose filtering, in addition to the considerations of chemistry synthesis. Validation criteria for a successful design include an X-ray co-crystal complex structure, in vitro biological data, and the number of compounds to be made, and these are addressed in this chapter as well.
Discovery of new G-quadruplex binding chemotypes (2013)

We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.
Evaluating early dementia with and without assessment of regional cerebral metabolism by PET: a comparison of predicted costs and benefits. (2002)

Appropriate use of PET for evaluating early dementia in geriatric patients can add valuable information to the clinical work-up, without adding to the overall costs of evaluation and management, resulting in a greater number of patients being accurately diagnosed for the same level of financial expenditure. Thus, the opportunity exists for diminishing the morbidity of dementia economically, with earlier institution of more appropriate management in evaluated patients.