gebhart/patrepeval huggingface dataset:
Delayed resolution of bleomycin-induced pulmonary fibrosis in absence of MMP13 (collagenase 3) (2019)

Matrix metalloprotease 13 (MMP13) deficiency in pulmonary fibrosis has described contradictory phenotypes on inflammatory and fibrotic responses after lung injury, and its role during lung fibrosis resolution is still undefined. MMP13 has been considered the main collagenase in rodents, and the remodeling of fibrillar collagen is widely attributed to the action of this enzyme. In this study we aimed to explore the role of MMP13 during lung fibrosis progression and resolution. Lung fibrosis was induced by intratracheal instillation, and inflammatory, fibrotic, and resolution stages were evaluated in <i>Mmp13</i>-null and wild-type (WT) mice. Bronchoalveolar lavage fluid was taken for cytokine array analysis and activity of gelatinases. Our results showed that MMP13 is upregulated mainly during two stages after lung injury, inflammation and resolution of fibrosis, and it is mainly expressed by alveolar and interstitial macrophages. <i>Mmp13</i>-null mice exhibited more extensive inflammation at 7 days after bleomycin treatment, and it was characterized by increased macrophage infiltration and significant alterations in proinflammatory cytokines. We also documented that <i>Mmp13</i>-deficient mice experienced more severe and prolonged lung fibrosis compared with WT mice. Delayed resolution in <i>Mmp13</i>-deficient lungs was characterized by a decreased overall collagenolytic activity and persistent fibrotic foci associated with emphysema-like areas. Together, our findings indicate that MMP13 plays an antifibrotic role and its activity is crucial in lung repair and restoration of tissue integrity during fibrosis resolution.
Zeolite‐Catalyzed Isomerization of Triose Sugars (2009)

Zeozymes: Sn-Beta zeolite is found to be a highly active catalyst for the conversion of triose sugars. If the solvent is water, isomerization of the triose sugars takes place to form lactic acid in 90 % yield at 125 °C. If methanol is used as the solvent, an overall isomerization–esterification reaction takes place and methyl lactate is formed in quantitative yields at 80 °C. This represents one of the most selective zeolite-catalyzed biomass transformation reactions. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Low-frequency sonophoresis: application to the transdermal delivery of macromolecules and hydrophilic drugs (2010)

Ultrasound technology has the potential to impact many more transdermal delivery platforms in the future due to its unique ability to enhance skin permeability in a controlled manner.
Orleans (2011)

Cloud computing is a new computing paradigm, combining diverse client devices -- PCs, smartphones, sensors, single-function, and embedded -- with computation and data storage in the cloud. As with every advance in computing, programming is a fundamental challenge, as the cloud is a concurrent, distributed system running on unreliable hardware and networks.
PSMA PET guided salvage radiotherapy among patients with prostate cancer in the post-prostatectomy setting: A single center post-hoc analysis. (2023)

5009 Background: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) shows improved sensitivity and specificity for detection of locoregional and distant metastatic prostate cancer (PCa) compared to conventional imaging, especially at lower PSA levels as is often the case in the biochemically recurrent (BCR), post radical prostatectomy (RP) setting. Providers are now utilizing PSMA PET findings to guide their salvage radiotherapy (sRT) treatment fields and doses, although it is not well understood how PSMA PET guided sRT impacts patient outcomes. Methods: This was a post-hoc analysis of 5 prospective studies of PSMA PET conducted at UCLA from 2016 to 2021 that included patients with recurrent PCa following RP. Patients were included in this retrospective study if they initiated sRT within 3 months of PSMA PET, had at least 12 months of follow up after sRT completion, had available sRT treatment details, and did not have distant metastases (DM) by conventional imaging on upfront staging. Patients treated with palliative RT were excluded. BCR following sRT was defined as an increase in PSA of 0.2 ng/ml above the post sRT nadir. Metastasis directed therapy (MDT) was defined as sRT to all PSMA+ N1 and M1 lesions. Baseline patient demographics, PSMA PET findings, sRT &amp; ADT treatment details, and patient outcome data were collected. Results: 176 patients were included in this study. Median time between RP and PSMA PET was 38 months (range 1-329). Median PSA at the time of the PSMA PET was 0.625 ng/mL (range 0.063-35). PSMA PET was positive in 128 patients (73%): 21 (12%) miT+N0M0, 55 (31%) miTxN1M0 and 52 (30%) miTxNxM1 with 19 (11%) miTxNxM1a, 31 (18%) miTxNxM1b, and 2 (1%) miTxNxM1c. Median number of lesions seen on positive PSMA scans was 1 (range 1-8). 39 (22%) patients were subsequently treated with sRT to the prostate bed (PB) only, 59 (34%) to PB + pelvic lymph nodes (PLNs), 33 (19%) to PLNs only, 7 (4%) to PB + PLNs + DM, 7 (4%) to PLNs + DM, and 31 (18%) to DM only. 59 (34%) patients were treated with concurrent ADT at a median duration of 6 months (range 1-39). At a median follow-up of 32 months (range 12-70) after sRT, 80 patients (45%) did not develop BCR or imaging relapse (IR) following sRT, 24 patients (14%) developed BCR but not IR, 1 patient (&lt;1%) developed IR only, and 70 patients (40%) developed both BCR and IR. The median time to BCR and IR following sRT was 15 months (range 1-48) and 19 months (range 6-61), respectively. 1 year post sRT biochemical recurrence free survival was 77%. Of the 83 patients treated with MDT, 32 (39%) did not develop subsequent disease relapse. Conclusions: This post-hoc analysis assessed the outcomes of 176 patients treated with PSMA PET guided salvage RT, proving it to be an effective method for treating both pelvic and extrapelvic recurrent PCa. Further investigation is needed to assess the full extent of patient outcomes in this population.
A vortex particle method for smoke, water and explosions (2005)

Vorticity confinement reintroduces the small scale detail lost when using efficient semi-Lagrangian schemes for simulating smoke and fire. However, it only amplifies the existing vorticity, and thus can be insufficient for highly turbulent effects such as explosions or rough water. We introduce a new hybrid technique that makes synergistic use of Lagrangian vortex particle methods and Eulerian grid based methods to overcome the weaknesses of both. Our approach uses vorticity confinement itself to couple these two methods together. We demonstrate that this approach can generate highly turbulent effects unachievable by standard grid based methods, and show applications to smoke, water and explosion simulations.
Supplementary Fig. S1 from Optimization of antibody binding to FcγRIIa enhances macrophage phagocytosis of tumor cells (2023)

Supplementary Fig. S1 from Optimization of antibody binding to FcγRIIa enhances macrophage phagocytosis of tumor cells
Mechanisms of Oral Tolerance by MHC Peptides (1996)

Recent evidence indicates that MHC peptides play an important role in T-cell recognition of alloantigen. We studied the tolerogenicity of orally administered synthetic MHC allopeptides in the rat model. Initially, we demonstrated that oral administration of synthetic class II MHC allopeptides significantly inhibited the DTH response to the peptides as well as to donor-derived cells. The tolerogenic effect was antigen specific and was induced by immunogenic, but not by nonimmunogenic, allopeptides. Immunohistological studies of DTH skin lesions showed that oral tolerance is associated with a state of "immune deviation" to a predominance of Th2 cell function in the lesions. We recently extended the above observations and examined the tolerogenic effect of orally administered synthetic MHC allopeptides on MLR and CTL generation. We found that oral administration of the class II allopeptides effected significant reduction of MLR proliferation and CTL generation, which was antigen specific. In addition, similar to the DTH results when we compared the tolerogenicity of the immunogenic versus the nonimmunogenic peptides, MLR and CTL suppression was significantly higher with the immunogenic peptides. The gut immune system play an important role in oral tolerance by MHC peptides. Initial experiments showed that intestinal epithelial cells pulsed in vitro with immunogenic MHC allopeptides, or in vivo by oral administration of immunogenic peptides, were capable of presenting these peptides to primed T cells in vitro. Whether such presentation by intestinal epithelial cells or other gut antigen-presenting cells leads to preferential activation of Th2 regulatory cells, which ultimately suppress Th1 alloimmune responses, remains to be determined.
David T. Blackstock and kidney stone lithotripsy (2021)

For the past 25 years, David Blackstock served as External Advisor to an NIH Program Project Grant (PPG) dedicated to improving shock wave lithotripsy (SWL) of kidney stones. Invented in the 1980s, SWL revolutionized stone management, eliminating the need for open surgery. As a truly noninvasive surgery, SWL remains the flagship of medical acoustic therapies. Study of its engineering, bioeffects, and physical mechanisms of action helped make SWL safer and more effective and led to new modalities of diagnostic and therapeutic ultrasound. Dr. Blackstock’s role in this effort cannot be overstated. He was a regular participant in our series of in-depth, two-day, semiannual meetings where in addition to reviewing new data related to his areas of expertise in shock wave propagation and nonlinear acoustics he absorbed, dissected, and eloquently critiqued research in the broad array of fields (e.g., clinical urology, renal vascular physiology and pathology, fracture mechanics, and more) otherwise unrelated to his experience. Dr. Blackstock had the ability to learn on the spot and then add incisive, valuable suggestions based on his expertise, intuition, and critical thinking. He kept us focused. He elevated our thinking. He stimulated our creativity and encouraged us toward new ideas. Work supported by NIH-P01-DK043881.
Grading Apical Vertebral Rotation Without a Computed Tomography Scan (2009)

An accurate assessment of vertebral rotation can be performed radiographically, using screw lengths and screw tip-to-rod distances of bilateral segmental pedicle screws and a trigonometric calculation. These data support the use of a simple radiographic grading system to approximate apical vertebral rotation in AIS patients treated with bilateral apical pedicle screws.
High power sources for ultrasound thermal therapy and shock wave lithotripsy (2008)

We present a summary of Inserm's experience with high power sources, which are necessary for ultrasound thermal therapy and lithotripsy. Moreover, generating high intensity pseudo-continuous waveforms or high pressure pulses imposes different constraints on the transducer materials, specifically heat and mechanical stress. For thermal therapy, miniature piezoceramic transducers were used for interstitial, intratumoral, and endoluminal applicators. These probes operated at surface intensities up to 50 W/cm2 and generated elementary lesions in vivo within tens of seconds. Piezocomposite transducers were developed for large-aperture, highly-focused beams used in extracorporeal or intraoperative treatments. Focal intensities were 1000 W/cm2 or higher and up to 256 elements were utilized. Miniaturized piezocomposite transducers are currently being developed for dual-mode imaging and therapy. For lithotripsy, piezoelectric shock wave generators were developed as alternatives to electrohydraulic or electromagnetic generators. Using piezocomposite materials and a novel prestraining method increased transducer surface pressure compared to a multielement piezoceramic design, and therefore halved the aperture diameter. In in vitro tests, plaster kidney stone models were comminuted with ∼200 shock waves, a number comparable to values published for electrohydraulic generators, the current “gold” standard. This work contributes to the advancement of transducer performance in therapeutic ultrasound. [Supported by Inserm Post-doctoral Fellowship.]
Is Mixing 50 GHz-Spaced 32 GBaud Channels and 75GHz-Spaced 64 GBaud Ones Useful in a WDM Elastic Network? (2018)

For two WDM core elastic networks, we study whether mixing 50-GHz and 75-GHz carrier spaces brings enough extra network capacity to offset the related complexity of wavelength allocation.
Physiological Tensioning During Lower Trapezius Transfer for Irreparable Posterosuperior Rotator Cuff Tears May Be Important for Improvement in Shoulder Kinematics (2023)

Tensioning during LTT for an irreparable PSRCT may be important to sufficiently improve glenohumeral kinematics and may be an intraoperatively modifiable key variable to ensure postoperative functional success.
Chemically Locked Bicelles with High Thermal and Kinetic Stability (2015)

In situ polymerization of a bicellar mixture composed of a phospholipid and polymerizable surfactants afforded unprecedented stable bicelles. The polymerized composite showed an aligned phase over a wide thermal range (25 to >90 °C) with excellent (2)H quadrupole splitting of the solvent signal, thus implying versatility as an alignment medium for NMR studies. Crosslinking of the surfactants also brought favorable effects on the kinetic stability and alignment morphology of the bicelles. This system could thus offer a new class of scaffolds for biomembrane models.
Front Matter: Volume 11361 (2020)

This PDF file contains the front matter associated with SPIE Proceedings Volume 11361 including the Title Page, Copyright information, Table of Contents, Introduction, and Conference Committee listing.
Second-harmonic generation in a novel crosslinked pyroelectric liquid crystal polymer (PLCP) (1998)

We report second-harmonic generation in samples with a pyroelectric liquid crystal polymer (PLCP) prepared from the ferroelectric liquid crystalline acrylate monomer 4-[(R)-(-)-2-(10-acryloyloxydecyl)oxy]-3-nitrophenyl 4-[4-(11-acryloyloxyundecyloxy)phenyl]- benzoate (A2c) by in situ photopolymerization. The relation between SHG efficiency, spontaneous polarization and amount of chiral substance in this and previously synthesized PLCP materials is discussed. Electro-optical properties of the monomeric and crosslinked A2c are investigated. In the crosslinked state, the molecular mobility is found to be very low, supporting the fact that the degree of polar order in the polymer is high. In contrast to the case of a poled electret NLO material, the polarization of this material is not 'frozen-in', but an intrinsic thermodynamic property.
Exosome-Mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing (2020)

Bidirectional cell-cell communication involving exosome-borne cargo such as miRNA has emerged as a critical mechanism for wound healing. Unlike other shedding vesicles, exosomes selectively package miRNA by SUMOylation of heterogeneous nuclear ribonucleoproteinA2B1 (hnRNPA2B1). In this work, we elucidate the significance of exosome in keratinocyte-macrophage crosstalk following injury. Keratinocyte-derived exosomes were genetically labeled with GFP-reporter (Exo<sub>κ-GFP</sub>) using tissue nanotransfection (TNT), and they were isolated from dorsal murine skin and wound-edge tissue by affinity selection using magnetic beads. Surface N-glycans of Exo<sub>κ-GFP</sub> were also characterized. Unlike skin exosome, wound-edge Exo<sub>κ-GFP</sub> demonstrated characteristic N-glycan ions with abundance of low-base-pair RNA and was selectively engulfed by wound macrophages (ωmϕ) in granulation tissue. <i>In vitro</i> addition of wound-edge Exo<sub>κ-GFP</sub> to proinflammatory ωmϕ resulted in conversion to a proresolution phenotype. To selectively inhibit miRNA packaging within Exo<sub>κ-GFP</sub><i>in vivo</i>, pH-responsive keratinocyte-targeted siRNA-hnRNPA2B1 functionalized lipid nanoparticles (TLNP<sub>κ</sub>) were designed with 94.3% encapsulation efficiency. Application of TLNP<sub>κ/si-hnRNPA2B1</sub> to the murine dorsal wound-edge significantly inhibited expression of hnRNPA2B1 by 80% in epidermis compared to the TLNP<sub>κ/si-control</sub> group. Although no significant difference in wound closure or re-epithelialization was observed, the TLNP<sub>κ/si-hnRNPA2B1</sub> treated group showed a significant increase in ωmϕ displaying proinflammatory markers in the granulation tissue at day 10 post-wounding compared to the TLNP<sub>κ/si-control</sub> group. Furthermore, TLNP<sub>κ/si-hnRNPA2B1</sub> treated mice showed impaired barrier function with diminished expression of epithelial junctional proteins, lending credence to the notion that unresolved inflammation results in leaky skin. This work provides insight wherein Exo<sub>κ-GFP</sub> is recognized as a major contributor that regulates macrophage trafficking and epithelial barrier properties postinjury.
Interface property–functionality interplay suppresses bimolecular recombination facilitating above 18% efficiency organic solar cells embracing simplistic fabrication (2023)

The donor/acceptor interface properties play vital roles not only for singlet exciton dissociation but also to suppress the free charge recombination enabling state-of-the-art device fill factors (FFs).
Ocular Trauma Following Amniocentesis as the Cause of Leukocoria (1988)

Among the various causes of leukocoria in a newborn, intrauterine ocular trauma following amniocentesis is not included. We describe a three-day-old girl whose leukocoria of the left eye resulted from traction retinal detachment, caused by the perforation of the globe during diagnostic amniocentesis.
New Video Codec for High-Quality Video Service and Emerging Applications (2019)

This paper proposes a novel video compression scheme for high-quality video service and emerging applications such as 360-degree omnidirectional and high dynamic range video coding. The coding framework supports hierarchical splitting of blocks with binary and ternary-split trees and flexible coding order representations. Moreover, minimal tool set to obtain high precision prediction and compression enhancement has been proposed. Compared to HEVC, bit-rate reduction of around 40% based on objective measures has been shown. This was one of the responses to the Call for Proposals (CfP) for VVC standardization.
Force sensorless force control using notch-type friction free disturbance observer (2018)

This paper proposes force sensorless force control using the notch-type friction free disturbance observer. The force control is structured by acceleration and speed controllers. The reaction force estimation system reduces the effect of the static friction using a dither signal. A conventional friction free disturbance observer becomes unstable when a low-frequency dither signal is applied. To solve this problem, the notch-type friction free disturbance observer is employed, which allows the use of low-frequency dither signals. This paper explains the difference between the conventional design method and the proposed design method. The validity of the proposed notch- type friction free disturbance observer is verified through the experimental results using an actual industrial robot.
What Can We Learn from Multi-Objective Meta-Optimization of Evolutionary Algorithms in Continuous Domains? (2019)

Properly configuring Evolutionary Algorithms (EAs) is a challenging task made difficult by many different details that affect EAs’ performance, such as the properties of the fitness function, time and computational constraints, and many others. EAs’ meta-optimization methods, in which a metaheuristic is used to tune the parameters of another (lower-level) metaheuristic which optimizes a given target function, most often rely on the optimization of a single property of the lower-level method. In this paper, we show that by using a multi-objective genetic algorithm to tune an EA, it is possible not only to find good parameter sets considering more objectives at the same time but also to derive generalizable results which can provide guidelines for designing EA-based applications. In particular, we present a general framework for multi-objective meta-optimization, to show that “going multi-objective” allows one to generate configurations that, besides optimally fitting an EA to a given problem, also perform well on previously unseen ones.
Reduction-induced CO dissociation by a [Mn(bpy)(CO)4][SbF6] complex and its relevance in electrocatalytic CO2reduction (2019)

[Mn(bpy)(CO)3Br] is recognized as a benchmark electrocatalyst for CO2 reduction to CO, with the doubly reduced [Mn(bpy)(CO)3]- proposed to be the active species in the catalytic mechanism. The reaction of this intermediate with CO2 and two protons is expected to produce the tetracarbonyl cation, [Mn(bpy)(CO)4]+, thereby closing the catalytic cycle. However, this species has not been experimentally observed. In this study, [Mn(bpy)(CO)4][SbF6] (1) was directly synthesized and found to be an efficient electrocatalyst for the reduction of CO2 to CO in the presence of H2O. Complex 1 was characterized using X-ray crystallography as well as IR and UV-Vis spectroscopy. The redox activity of 1 was determined using cyclic voltammetry and compared with that of benchmark manganese complexes, e.g., [Mn(bpy)(CO)3Br] (2) and [Mn(bpy)(CO)3(MeCN)][PF6] (3). Infrared spectroscopic analyses indicated that CO dissociation occurs after a single-electron reduction of complex 1, producing a [Mn(bpy)(CO)3(MeCN)]+ species. Complex 1 was experimentally verified as both a precatalyst and an on-cycle intermediate in homogeneous Mn-based electrocatalytic CO2 reduction.
Four-year Water Degradation of Total-etch Adhesives Bonded to Dentin (2003)

Resin-dentin bonds degrade over time. The objective of this study was to evaluate the influence of variables like hybridization effectiveness and diffusion/elution of interface components on degradation. Hypotheses tested were: (1) There is no difference in degradation over time between two- and three-step total-etch adhesives; and (2) a composite-enamel bond protects the adjacent composite-dentin bond against degradation. The micro-tensile bond strength (microTBS) to dentin of 2 three-step total-etch adhesives was compared with that of 2 two-step total-etch adhesives after 4 years of storage in water. Quantitative and qualitative failure analyses were conducted correlating Fe-SEM and TEM. Indirect exposure to water did not significantly reduce the microTBS of any adhesive, while direct exposure resulted in a significantly reduced microTBS of both two-step adhesives. It is concluded that resin bonded to enamel protected the resin-dentin bond against degradation, while direct exposure to water for 4 years affected bonds produced by two-step total-etch adhesives.
Design of resonant mirrors with negative group delay (2014)

Resonant mirrors introduce large spectral gradients in reflected phase while maintaining high reflectivity, allowing synthesis of optimized reflected phase for many practical applications. In this paper we show theoretically that asymmetry is required for negative group delay in lossless mirrors and explore the limits of reflected phase in resonant mirrors through the use of coupled mode theory and rigorous couple wave analysis. Our coupled mode theory shows that the phase response of resonant mirrors is determined by interacting resonances and gives insight into tradeoffs in design of mirrors with desired phase response.