gebhart/patrepeval huggingface dataset:
The Proliferation and Migration Effects of Huangqi on RSC96 Schwann Cells (2009)

This study evaluated the proliferation effects of huangqi on neuron regeneration. We investigated the molecular mechanisms, which include: (1) cyclin D1, A, E-cell cycle factors and MAPK signaling proliferation (2) FGF-2-UPA-MMPs migration signaling. After treatment with various Huanqi concentrations (1.25, 12.5, 125, 250 and 500 microg/ml,), we observed that Huanqi can increase Rsc 96 cell proliferation at 12.5 microg/ml (p < 0.01) concentration determined by the MTT and wound healing tests. Examination by RT-PCR and Western blotting assay showed that Huangqi is able to stimulate the mRNA and protein expressions of cyclin D1, A, E, cell cycle controlling proteins and excite ERK and P38 MAPK signaling pathways to promote cell proliferation. Huangqi stimulates the FGF-2-UPA-MMP 9 migration pathway and enhances RSC 96 Schwann cells migration. Using MAPK chemical inhibitors, U0126, SB203580 and SP600125, the proliferative effects of Huangqi on RSC 96 cells were ERK and P38 signaling-dependent. Based on these results, applying an appropriate dose of Huangqi with biomedical materials would be a potential approach to enhancing neuron regeneration.
Permeability of carbon dioxide at elevated pressures in substituted polycarbonates (1990)

Abstract Past work has shown that hysteresis in sorption, volume dilation, and permeation result when standard bisphenol A polycarbonate is conditioned by exposure to 900 psia carbon dioxide at 35°C. This article reports hysteretic permeation results for the same polycarbonate exposed to other carbon dioxide conditioning pressures. Furthermore, permeation results are reported for tetramethyl and hexafluoropolycarbonate following conditioning with carbon dioxide. Permeation measurements with these structurally related polycarbonates show qualitatively similar, but quantitatively smaller long‐lived hysteretic effects compared with standard polycarbonate dilated to similar volume percentages. The percentage increase in permeability following conditioning treatments will be discussed in terms of fractional free volume considerations.
Different factor VIII neutralizing effects on anti‐factor VIII inhibitor antibodies associated with epitope specificity and von Willebrand factor (2013)

Inhibitor neutralization therapy based on factor (F)VIII replacement is used for haemostatic treatment in haemophilia A patients with inhibitors on low responder, but effects appear to depend on various properties of inhibitors. We investigated this nature by evaluating the global coagulation function in timed-reactions after mixing FVIII (1 U/ml) with anti-FVIII alloantibodies containing distinct epitopes (2·5 Bethesda units/ml). Thrombin generation assays showed that peak thrombin and mean velocity to peak thrombin were depressed by anti-C2 type 1 inhibitors to significantly greater extents than by anti-A2 type 1 and anti-C2 type 2 (2- to 6-fold and 10- to 20-fold, respectively). In the presence of FVIII-von Willebrand Factor (VWF) complex, the anti-C2 type 1-mediated decreased thrombin generation was reduced by 20-40%, reflecting the protective function of VWF. However, the activities of anti-A2 type 1 were little affected, and that of anti-C2 type 2 was rather enhanced by c. 2·5-fold, relative to FVIII. Clot waveform analysis also showed similar patterns. Anti-FVIII monoclonal antibodies with well-defined characteristics demonstrated similar reactions to those with polyclonal inhibitors. In conclusion, the neutralizing effects of FVIII(-VWF) depending on epitopes could have significant therapeutic implications, and it could be important to determine inhibitor properties in order to predict the effects of infused FVIII in neutralization therapy.
Pre–Radiation Therapy Fluorine 18 Fluorodeoxyglucose PET Helps Identify Patients with Esophageal Cancer at High Risk for Radiation Pneumonitis (2015)

The SUV95, a biomarker of pretreatment pulmonary metabolic activity, was shown to be prognostic of symptomatic RP. Elevation in this pretreatment biomarker identifies patients at high risk for posttreatment symptomatic RP.
Frequency-domain modeling of semiconductor mode lock lasers (2020)

A frequency-domain description of semiconductor mode-locked lasers is presented. The approach provides self-consistent accounting of locking mechanism, gain saturation, mode competition and carrier-induced refractive index, in addition to directly connecting mode-locking performance to the bandstructure.
Reduced Order Method Based on an Adaptive Formulation and its Application to Fan Blade System With Dovetail Joints (2020)

Abstract Localized nonlinearities due to the contact friction interfaces are widely present in the aero-engine structures. They can significantly reduce the vibration amplitudes and shift the resonance frequencies away from critical operating speeds, by exploiting the frictional energy dissipation at the contact interface. However, the modelling capability to predict the dynamics of such large-scale systems with these nonlinearities is often impeded by the high computational expense. Component mode synthesis (CMS) based reduced order modelling (ROM) are commonly used to overcome this problem in jointed structures. However, the computational efficiency of these classical ROMs are sometimes limited as their size is proportional to the DOFs of joint interfaces resulting in a full dense matrix. A new ROM based on an adaptive formulation is proposed in this paper to improve the CMS methods for reliable predictions of the dynamics in jointed structures. This new ROM approach is able to adaptively switch the sticking contact nodes off during the online computation leading to a significant size reduction comparing to the CMS based models. The large-scale high fidelity fan blade assembly is used as the case study. The forced response obtained from the novel ROM is compared to the state-of-the-art CMS based Craig-Bampton method. A parametric study is then carried out to assess the influence of the contact parameters on the dynamics of the fan assembly. The feasibility of using this proposed method for nonlinear modal analysis is also characterised.
A practical scheduling scheme for non-uniform parallel loops on distributed memory parallel machines (1996)

Loops without dependences among iterations are a rich source of parallelism in many applications. Among these types of loops, non-uniform loops with variable execution times need efficient scheduling schemes to take advantages of the capabilities of parallel machines. We present a global distributed control scheme (GDC) to schedule nonuniform loops on distributed memory parallel machines. GDC decentralizes scheduling controls among all processors with an attempt to keep heavily loaded processors being in charge of scheduling tasks. For comparative evaluation, GDC and other well-known scheduling schemes are implemented on a 512 processor Intel Delta parallel machine. Our experimental results show that GDC performs well on many applications with different characteristics.
Stroke prevention during and after transcatheter aortic valve implantation: From cerebral protection devices to antithrombotic management (2022)

Since its conception, transcatheter aortic valve implantation (TAVI) has undergone important improvements both in the implantation technique and in transcatheter devices, allowing an enthusiastic adoption of this therapeutic approach in a wide population of patients previously without a surgical option and managed conservatively. Nowadays, patients with severe symptomatic aortic stenosis are typically managed with TAVI, regardless of their risk to surgery, improving the prognosis of patients and thus achieving an exponential global expansion of its use. However, thromboembolic and hemorrhagic complications remain a latent concern in TAVI recipients. Both complications can appear simultaneously in the periprocedural period or during the follow-up, and when minor, they resolved without apparent sequelae, but in a relevant percentage of cases, they are devastating, overshadowing the benefit achieved with TAVI. Our review outlines the etiology and incidence of thromboembolic complications associated with TAVI, the main current strategies for their prevention, and the implications of its pharmacological management at the follow-up in a TAVI population, mostly frail and predisposed to bleeding complications.
New solutions for substation sensing, signal processing and decision making (2004)

This paper describes a new solution for integrating substation sensing, signal processing and decision making for more efficient monitoring, control and protection applications. The paper points out deficiencies of the existing approach and sets the requirements for the new approach. Once an architecture of the new solution is defined, further description of each of the elements of the new solution, namely optical sensor multiplexed network, distributed signal processing, and neural network based decision making are discussed. At the end, a concept of how all the mentioned components of the solution can be integrated is given.
Automated ARGET ATRP Accelerates Catalyst Optimization for the Synthesis of Thiol-Functionalized Polymers (2012)

Conventional synthesis of polymers by ATRP is relatively low throughput, involving iterative optimization of conditions in an inert atmosphere. Automated, high-throughput controlled radical polymerization was developed to accelerate catalyst optimization and production of disulfide-functionalized polymers without the need of an inert gas. Using ARGET ATRP, polymerization conditions were rapidly identified for eight different monomers, including the first ARGET ATRP of 2-(diethylamino)ethyl methacrylate and di(ethylene glycol) methyl ether methacrylate. In addition, butyl acrylate, oligo(ethylene glycol) methacrylate 300 and 475, 2-(dimethylamino)ethyl methacrylate, styrene, and methyl methacrylate were polymerized using bis(2-hydroxyethyl) disulfide bis(2-bromo-2-methylpropionate) as the initiator, tris(2-pyridylmethyl)amine as the ligand, and tin(II) 2-ethylhexanoate as the reducing agent. The catalyst and reducing agent concentration was optimized specifically for each monomer, and then a library of polymers was synthesized systematically using the optimized conditions. The disulfide-functionalized chains could be cleaved to two thiol-terminated chains upon exposure to dithiothreitol, which may have utility for the synthesis of polymer bioconjugates. Finally, we demonstrated that these new conditions translated perfectly to conventional batch polymerization. We believe the methods developed here may prove generally useful to accelerate the systematic optimization of a variety of chemical reactions and polymerizations.
Novel Wafer Level Package Technology Studies for Image Sensor Devices (2006)

Wafer level package for optical image sensor devices are known to be processed by re-routing of the bond pads to the back side of the chip, through (T) contacts located at the die edges. Bond pad back via contact wafer level packaging technology has been developed by Schott Electronic Packaging GmbH, Germany, which is proven to be with a number of advantages over the mechanically processed (T) contact wafer level packages. Direct contact of the bond pads from the back side of the chip offers much shorter transmission paths to the board assemblies, thus allowing faster signal speed, efficient thermal conduction and many added advantages. Also, the new technology offers area contacts with in the seal ring/isolation boundary of the device, there-by providing much higher performance for the packaged devices. The reliability of this new WLP technology has been demonstrated by testing the same for various reliability test conditions as per JEDEC/JIS standards. This paper discusses the process technology and reliability tests/results carried out on a consumer application chip, namely image sensor device.
Plasmonic bound states in the continuum for unpolarized weak spatially coherent light (2022)

Plasmonic resonances empowered by bound states in the continuum (BICs) offer unprecedented opportunities to tailor light–matter interaction. However, excitation of high quality-factor ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="m1"> <mml:mrow> <mml:mi>Q</mml:mi> </mml:mrow> </mml:math> -factor) quasi-BICs is often limited to collimated light at specific polarization and incident directions, rendering challenges for unpolarized focused light. The major hurdle is the lack of robustness against weak spatial coherence and poor polarization of incident light. Here, addressing this limitation, we demonstrate sharp resonances in symmetric plasmonic metasurfaces by exploiting BICs in the parameter space, offering ultraweak angular dispersion effect and polarization-independent performance. Specifically, a high- <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="m2"> <mml:mrow> <mml:mi>Q</mml:mi> </mml:mrow> </mml:math> ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="m3"> <mml:mrow> <mml:mo form="prefix">≈</mml:mo> <mml:mn>71</mml:mn> </mml:mrow> </mml:math> ) resonance with near-perfect absorption ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="m4"> <mml:mrow> <mml:mo form="prefix">&gt;</mml:mo> <mml:mn>90</mml:mn> <mml:mi>%</mml:mi> </mml:mrow> </mml:math> ) is obtained for the input of unpolarized focused light covering wide incident angles (from 0° to 30°). Also, giant electric and magnetic field enhancement simultaneously occurs in quasi-BICs. These results provide a way to achieve efficient near-field enhancement using focused light produced by high numerical aperture objectives.
A 90nm SiGe BiCMOS technology for mm-wave and high-performance analog applications (2014)

We present the electrical characteristics of the first 90nm SiGe BiCMOS technology developed for production in IBM's large volume 200mm fabrication line. The technology features 300 GHz f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> and 360 GHz f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MAX</sub> high performance SiGe HBTs, 135 GHz f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> and 2.5V BV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CEO</sub> medium breakdown SiGe HBTs, 90nm Low Power RF CMOS, and a full suite of passive devices. A design kit supports custom and analog designs and a library of digital functions aids logic and memory design. The technology supports mm-wave and high-performance RF/Analog applications.
Tumor‐specific expression and detection of a CEST reporter gene (2015)

The PEG-3 promoter:LRP system can be used as a cancer-specific, molecular-genetic imaging reporter system in vivo. Because of the ubiquity of MR imaging in clinical practice, sensors of this class can be used to translate molecular-genetic imaging rapidly.
A Generic Method for Automatic Ground Truth Generation of\n Camera-captured Documents (2016)

The contribution of this paper is fourfold. The first contribution is a\nnovel, generic method for automatic ground truth generation of camera-captured\ndocument images (books, magazines, articles, invoices, etc.). It enables us to\nbuild large-scale (i.e., millions of images) labeled camera-captured/scanned\ndocuments datasets, without any human intervention. The method is generic,\nlanguage independent and can be used for generation of labeled documents\ndatasets (both scanned and cameracaptured) in any cursive and non-cursive\nlanguage, e.g., English, Russian, Arabic, Urdu, etc. To assess the\neffectiveness of the presented method, two different datasets in English and\nRussian are generated using the presented method. Evaluation of samples from\nthe two datasets shows that 99:98% of the images were correctly labeled. The\nsecond contribution is a large dataset (called C3Wi) of camera-captured\ncharacters and words images, comprising 1 million word images (10 million\ncharacter images), captured in a real camera-based acquisition. This dataset\ncan be used for training as well as testing of character recognition systems on\ncamera-captured documents. The third contribution is a novel method for the\nrecognition of cameracaptured document images. The proposed method is based on\nLong Short-Term Memory and outperforms the state-of-the-art methods for camera\nbased OCRs. As a fourth contribution, various benchmark tests are performed to\nuncover the behavior of commercial (ABBYY), open source (Tesseract), and the\npresented camera-based OCR using the presented C3Wi dataset. Evaluation results\nreveal that the existing OCRs, which already get very high accuracies on\nscanned documents, have limited performance on camera-captured document images;\nwhere ABBYY has an accuracy of 75%, Tesseract an accuracy of 50.22%, while the\npresented character recognition system has an accuracy of 95.10%.\n
Mechanisms of Oncogene Activation (2022)

Cellular genes whose expression can be associated with the transformed phenotype were first recognized as coopted cellular genes inserted by transduction into retroviral genomes and responsible for most of the tumors induced by acute retroviruses. This chapter reviews different mechanisms which can activate an oncogene. Activation is used to indicate an alteration, at regulatory or structural level or at both, that affects the normal cellular allele of the oncogene itself. The distinction between regulatory and structural alterations is also exemplified by two well known cases of oncogene activation following chromosomal translocation. Recent observations have provided evidence for another class of oncogenes, in which tumor-inducing alterations are recessive of the wild-type alleles.
Assessing Risk of Future Suicidality in Emergency Department Patients (2018)

Using CFI-S, or some of its items, in busy EDs may help improve the detection of patients at high risk for future suicidality.
THE BOLEO COPPER-COBALT-ZINC-MANGANESE PROJECT (2008)

AbstractAbstractThe Boleo project is located in Mexico close to the town of Santa Rosalia on the Baja Peninsula. The Boleo deposit contains copper, cobalt, zinc and manganese values as oxides with minor sulphides. The Boleo deposit is metallurgically challenging due to: 1) the requirement to recover four separate metals 2) the presence of high levels of clay in the deposit resulting in difficult solid-liquid separations and 3) the need to use seawater for the bulk of the processing. The key steps in the flowsheet are:1. Feed preparation (scrubbing and ball milling of oversize) in copper raffinate2. Ore leaching using oxidative and reductive leaching3. Countercurrent Decantation (CCD) washing using high rate thickening technology4. Copper solvent extraction/electrowinning (SX/EW)5. Treatment of a bleed solution for cobalt, zinc and manganese recoveryThe process for cobalt, zinc and manganese recovery involves iron and aluminum removal followed by cobalt/zinc bulk extraction using CSIRO's DSX solvent extraction system and selective zinc and cobalt stripping. The zinc strip solution is evaporated to produce zinc sulphate monohydrate crystals to market and cobalt is recovered via a further SX/EW process as high purity metal. Manganese is precipitated as manganese carbonate from the direct solvent extraction (DSX) raffinate.Le projet Boléo est situé au Mexique, près de la ville de Santa Rosalia, sur la Péninsule Baja. Le dépôt de Boléo contient des valeurs de cuivre, de cobalt, de zinc et de manganèse sous forme d'oxydes avec des sulfures mineurs. Le dépôt de Boléo est ambitieux du point de vue métallurgique à cause de: 1) l'exigence de récupérer quatre métaux séparés 2) la présence de niveaux élevés d'argile dans le dépôt résultant en séparations solide-liquide difficiles et 3) le besoin d'utiliser de l'eau de mer pour la majorité du traitement. Les étapes clés du schéma de procédé sont:1. Préparation de l'alimentation (lavage et broyage avec boulets des déclassés trop grands) du raffinat de cuivre2. Lixiviation du minerai en utilisant la lixiviation oxydative et réductive3. Lavage à contre-courant par décantation (CCD) en utilisant la technologie d'épaississement à haute vitesse4. Extraction par solvant/électro-obtention (SX/EW) du cuivre5. Traitement de la solution d'exsudation pour la récupération du cobalt, du zinc et du manganèse.Le procédé de récupération du cobalt, du zinc et du manganèse implique l'enlèvement du fer et de l'aluminium suivi par l'extraction en vrac du cobalt/zinc en utilisant le système d'extraction par solvant DSX de CSIRO et le lavage sélectif du zinc et du cobalt. La solution de lavage du zinc est évaporée pour produire des cristaux de sulfate de zinc monohydrate pour la mise en marché et le cobalt est récupéré en métal de haute pureté par l'intermédiaire d'un autre procédé de SX/EW. Le manganèse est précipité sous forme de carbonate de manganèse à partir de l'extraction directe par solvant du raffinat.
Assembly of Ebola Virus Matrix Protein VP40 Is Regulated by Latch-Like Properties of N and C Terminal Tails (2012)

The matrix protein VP40 coordinates numerous functions in the viral life cycle of the Ebola virus. These range from the regulation of viral transcription to morphogenesis, packaging and budding of mature virions. Similar to the matrix proteins of other nonsegmented, negative-strand RNA viruses, VP40 proceeds through intermediate states of assembly (e.g. octamers) but it remains unclear how these intermediates are coordinated with the various stages of the life cycle. In this study, we investigate the molecular basis of synchronization as governed by VP40. Hydrogen/deuterium exchange mass spectrometry was used to follow induced structural and conformational changes in VP40. Together with computational modeling, we demonstrate that both extreme N and C terminal tail regions stabilize the monomeric state through a direct association. The tails appear to function as a latch, released upon a specific molecular trigger such as RNA ligation. We propose that triggered release of the tails permits the coordination of late-stage events in the viral life cycle, at the inner membrane of the host cell. Specifically, N-tail release exposes the L-domain motifs PTAP/PPEY to the transport and budding complexes, whereas triggered C-tail release could improve association with the site of budding.
Programmable and Open-Access Millimeter-Wave Radios in the PAWR COSMOS Testbed (2021)

While millimeter-wave (mmWave) wireless has recently gained tremendous attention with the transition to 5G, developing a broadly accessible experimental infrastructure will allow the research community to make significant progress in this area. Hence, in this paper, we present the design and implementation of various programmable and open-access 28/60 GHz software-defined radios (SDRs), deployed in the PAWR COSMOS advanced wireless testbed. These programmable mmWave radios are based on the IBM 28 GHz 64-element dual-polarized phased array antenna module (PAAM) subsystem board and the Sivers IMA 60 GHz WiGig transceiver. These front ends are integrated with USRP SDRs or Xilinx RF-SoC boards, which provide baseband signal processing capabilities. Moreover, we present measurements of the TX/RX beamforming performance and example experiments (e.g., real-time channel sounding and RFNoC-based 802.11ad preamble detection), using the mmWave radios. Finally, we discuss ongoing enhancement and development efforts focusing on these radios.
Copper‐Catalyzed Direct Alkenylation ofN‐Iminopyridinium Ylides (2009)

Pfennigfuchser: Eine vielseitige kupferkatalysierte direkte C-H-Alkenylierung von N-Iminopyridinium-Yliden, die mit einer Reihe von Kupferquellen kompatibel ist (darunter auch ein Penny), bietet eine leistungsfähige, billige Methode zur Synthese funktionalisierter Pyridinderivate. Die chemoselektive Funktionalisierung halogenhaltiger Verbindungen ermöglicht die Synthese von Alkenylpyridinen mit reaktiven Gruppen für eine weitere Funktionalisierung.