gebhart/patrepeval huggingface dataset:
∼8.5 μm-emitting InP-based quantum cascade lasers grown on GaAs by metal-organic chemical vapor deposition (2022)

Room-temperature, pulsed-operation lasing of 8.5 μm-emitting InP-based quantum cascade lasers (QCLs), with low threshold-current density and watt-level output power, is demonstrated from structures grown on (001) GaAs substrates by metal-organic chemical vapor deposition. Prior to growing the laser structure, which contains a 35-stage In0.53Ga0.47As/In0.52Al0.48As lattice-matched active-core region, a ∼2 μm-thick nearly fully relaxed InP buffer with strained 1.6 nm-thick InAs quantum-dot-like dislocation-filter layers was grown. A smooth terminal buffer-layer surface, with roughness as low as 0.4 nm on a 10 × 10 μm2 scale, was obtained, while the estimated threading-dislocation density was in the mid-range × 108 cm−2. A series of measurements, on lasers grown on InP metamorphic buffer layers (MBLs) and on native InP substrates, were performed for understanding the impact of the buffer-layer's surface roughness, residual strain, and threading-dislocation density on unipolar devices such as QCLs. As-cleaved devices, grown on InP MBLs, were fabricated as 25 μm × 3 mm deep-etched ridge guides with lateral current injection. The results are pulsed maximum output power of 1.95 W/facet and a low threshold-current density of 1.86 kA/cm2 at 293 K. These values are comparable to those obtained from devices grown on InP: 2.09 W/facet and 2.42 kA/cm2. This demonstrates the relative insensitivity of the device-performance metrics on high residual threading-dislocation density, and high-performance InP-based QCLs emitting near 8 μm can be achieved on lattice-mismatched substrates.
COMPARISON OF ONE-ELEMENT ANALYSIS RESULTS BY SOME NUMERICAL METHODS FOR JOINTED ROCK MASS (2000)

我が国では多くの地下発電所空洞建設の実績を有するが, 厳しい地質・地圧条件下での施工やより大断面の空洞掘削を可能にするためには, 空洞掘削時の岩盤挙動を正確に予測し得る解析手法の開発が不可欠である. 本研究では不連続性岩盤を対象とする最新の解析手法として, 節理の破壊を考慮したひずみ軟化解析, MBC解析, ロックボルト効果が考慮可能な等価連続体解析, 複合降伏モデル, クラックテンソルモデル, 損傷テンソルモデルを取り上げ, 簡単な節理条件に対する巨視的な等価せん断弾性係数の算定式により入力物性値の比較を行った. 次に, 既往の地下発電所空洞掘削時の岩盤変形挙動を最も良く再現できる入力パラメータを抽出し, 各解析手法による一要素解析結果の関係について論じた.
Tilt Analysis of Readback Signals from DVD-ROM Media (1998)

Although not considered a major problem for CDs, tilt is now being looked on as one of the major sources of distortion for the DVD mainly due to its smaller feature size and track pitch.
Calibration of the light-flavour jet mistagging efficiency of the b-tagging algorithms with Z+jets events using 139 $$\textrm{fb}^{-1}$$ of ATLAS proton–proton collision data at $$\sqrt{s} = 13$$ TeV (2023)

Abstract The identification of b -jets, referred to as b -tagging, is an important part of many physics analyses in the ATLAS experiment at the Large Hadron Collider and an accurate calibration of its performance is essential for high-quality physics results. This publication describes the calibration of the light-flavour jet mistagging efficiency in a data sample of proton–proton collision events at $$\sqrt{s}=13$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> </mml:mrow> </mml:math> TeV corresponding to an integrated luminosity of 139 fb $$^{-1}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mrow/> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:math> . The calibration is performed in a sample of Z bosons produced in association with jets. Due to the low mistagging efficiency for light-flavour jets, a method which uses modified versions of the b -tagging algorithms referred to as flip taggers is used in this work. A fit to the jet-flavour-sensitive secondary-vertex mass is performed to extract a scale factor from data, to correct the light-flavour jet mistagging efficiency in Monte Carlo simulations, while simultaneously correcting the b -jet efficiency. With this procedure, uncertainties coming from the modeling of jets from heavy-flavour hadrons are considerably lower than in previous calibrations of the mistagging scale factors, where they were dominant. The scale factors obtained in this calibration are consistent with unity within uncertainties.
Evaluating Energy-Efficient Schedulers on Underwater Acoustic Data (2019)

In this work, we evaluate energy-efficient schedulers for underwater acoustic point-to-point links on experimental data. We use the communication performance collected during KAM11, in order to estimate the channel statistics. We run an optimal, a heuristic, and a blind scheduler on these collected time series.
Application of Radio-Frequency Plasma Glow Discharge to Removal of Uranium Dioxide from Metal Surfaces (2000)

AbstractRecent experiments have shown that radio-frequency (rf) plasma glow discharge using NF3 gas is an effective technique for the removal of uranium oxide from metal surfaces. The results of these experiments are analyzed to explain the measured dependence of the UO2 removal or etch rate on the NF3 gas pressure and the absorbed power in the plasma. The NF3 gas pressure in the experiments was varied from 10.8 to 40 Pa, and the deposited power in the plasma was varied from 25 to 210 W. The UO2 etch rate was strongly dependent on the absorbed power and, to a lesser extent, on the NF3 pressure and decreased exponentially with immersion time. At 210 W and 17 Pa, all detectable UO2 in the samples (~10.6 mg each) was removed at the endpoint, whereas the initial etch rate was ~3.11 μm/min. When the absorbed power was ≤50 W, however, the etch rate was initially ~0.5 μg/min and almost zero at the endpoint, with UO2 only partially etched. This self-limiting etching of UO2 at low power is attributed to the formation of nonvolatile intermediates UF2, UF3, UF4, UF5, UO2F, and UO2F2 on the surface. Analysis indicated that the accumulation of UF6 and, to a lesser extent, O2 near the surface partially contributed to the exponential decrease in the UO2 etch rate with immersion time. Unlike fluorination with F2 gas, etching of UO2 using rf glow discharge is possible below 663 K. The average etch rates of the amorphous UO2 in the NF3 experiments are comparable to the peak values reported in other studies for crystalline UO2 using CF4/O2 glow discharge performed at ~150 to 250 K higher sample temperatures.
Optoelectronic Performance of Nitrogen-Doped Single-Walled Carbon Nanotube Films (2012)

We have studied the optical and electrical performance of nitrogen-doped single-walled carbon nanotube films, measured in terms of optical transmittance and sheet resistance. Using a simple resistor network model to study the geometric scaling of the optical transmittance to sheet resistance ratio, and data from similar undoped films, we show that the nitrogen-doped films have a significantly increased sheet resistance. The analysis shows that this effect is likely due to an increase in the intrabundle resistances. A possible cause is the increased backscattering of charge carriers by defect sites in the nanotubes.
Near-Null Response to Large-Signal Transients in an Augmented Buck Converter: A Geometric Approach (2011)

The maximum closed-loop bandwidth of a dc-dc converter is restricted to a fraction of its switching frequency when governed by a conventional average-based pulsewidth modulation (PWM) controller. Even an advanced geometric control is limited by internal slew rates. The bandwidth can reach or exceed the switching frequency through converter augmentation; however, this requires a nonlinear control algorithm and circuit arrangements. This paper considers methods of augmentation and control for a fast buck converter. Conditions for time-optimal transient recovery are obtained for both instantaneous and delayed transient disturbance detection. Design tradeoffs and control issues related to augmentation are considered here. The main switch is controlled using a fixed frequency PWM current-mode control with load current feedforward, and augmented switches are controlled using frequency-limited bang-bang control based on a geometric approach. A small-signal model is obtained and extended control bandwidth is demonstrated. Fast transient recovery is achieved for both single- and two-resistance augmentation. A prototype augmented buck converter is tested. Output voltage and inductor current overshoot and undershoot can be lowered more than with previous methods. It is possible to achieve near-null response in the sense of ripple band to a large-signal transient.
von Willebrand Factor and Factor VIII Clearance in Perioperative Hemophilia A Patients (2020)

VWF:Ag and VWF:GPIbM levels increase postoperatively, most significantly in patients with blood type non-O or medium risk surgery. Lower VWF antigen levels did not lead to clinically relevant higher FVIII clearance. VWF:Ag or VWF:GPIbM levels were not associated with perioperative hemorrhage.
Small-Molecule Investigation of Diels–Alder Complexes for Thermoreversible Crosslinking in Polymeric Applications (2021)

Combinations of dienes and dienophiles were examined in order to elicit possible combinations for thermoreversible crosslinking units. Comparison of experimental results and quantum calculations indicated that reaction kinetics and activation energy were much better prediction factors than change in enthalpy for the prediction of successful cycloaddition. Further testing on diene-dienophile pairs that underwent successful cycloaddition determined the feasibility of thermoreversibility/retro-reaction of each of the Diels-Alder compounds. Heating and testing of the compounds in the presence of a trapping agent allowed for experimental determination of reverse kinetics and activation energy for the retro-reaction. The experimental values were in good agreement with quantum calculations. The combination of chemical calculations with experimental results provided a strong insight into the structure-property relationships and how quantum calculations can be used to examine the feasibility of the thermoreversibility of new Diels-Alder complexes in potential polymer systems or to fine-tune thermoreversible Diels-Alder systems already in use.
Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer (2017)

Advanced ovarian cancers are highly metastatic due to frequent peritoneal dissemination, resulting in dismal prognosis. Here we report the functions of cancer-derived extracellular vesicles (EVs), which are emerging as important mediators of tumour metastasis. The EVs from highly metastatic cells strongly induce metastatic behaviour in moderately metastatic tumours. Notably, the cancer EVs efficiently induce apoptotic cell death in human mesothelial cells in vitro and in vivo, thus resulting in the destruction of the peritoneal mesothelium barrier. Whole transcriptome analysis shows that MMP1 is significantly elevated in mesothelial cells treated with highly metastatic cancer EVs and intact MMP1 mRNAs are selectively packaged in the EVs. Importantly, MMP1 expression in ovarian cancer is tightly correlated with a poor prognosis. Moreover, MMP1 mRNA-carrying EVs exist in the ascites of cancer patients and these EVs also induce apoptosis in mesothelial cells. Our findings elucidate a previously unknown mechanism of peritoneal dissemination via EVs.
Phasor Imaging (2015)

In correlation-based time-of-flight (C-ToF) imaging systems, light sources with temporally varying intensities illuminate the scene. Due to global illumination, the temporally varying radiance received at the sensor is a combination of light received along multiple paths. Recovering scene properties (e.g., scene depths) from the received radiance requires separating these contributions, which is challenging due to the complexity of global illumination and the additional temporal dimension of the radiance. We propose phasor imaging, a framework for performing fast inverse light transport analysis using C-ToF sensors. Phasor imaging is based on the idea that, by representing light transport quantities as phasors and light transport events as phasor transformations, light transport analysis can be simplified in the temporal frequency domain. We study the effect of temporal illumination frequencies on light transport and show that, for a broad range of scenes, global radiance (inter-reflections and volumetric scattering) vanishes for frequencies higher than a scene-dependent threshold. We use this observation for developing two novel scene recovery techniques. First, we present micro-ToF imaging, a ToF-based shape recovery technique that is robust to errors due to inter-reflections (multipath interference) and volumetric scattering. Second, we present a technique for separating the direct and global components of radiance. Both techniques require capturing as few as 3--4 images and minimal computations. We demonstrate the validity of the presented techniques via simulations and experiments performed with our hardware prototype.
Retro-inverso Urokinase Receptor Antagonists for the Treatment of Metastatic Sarcomas (2017)

The development of metastases is a multistep process that requires the activation of physiological and biochemical processes that govern migration, invasion and entry of metastatic cells into blood vessels. The urokinase receptor (uPAR) promotes cell migration by interacting with the Formyl Peptide Receptors (FPRs). Since both uPAR and FPR1 are involved in tumor progression, the uPAR-FPR1 interaction is an attractive therapeutic target. We previously described peptide antagonists of the uPAR-FPR1 interaction that inhibited cell migration and angiogenesis. To develop enzyme-resistant analogues, we applied here the Retro-Inverso (RI) approach, whereby the topology of the side chains is maintained by inverting the sequence of the peptide and the chirality of all residues. Molecular dynamics suggests that peptide RI-3 adopts the turn structure typical of uPAR-FPR1 antagonists. Accordingly, RI-3 is a nanomolar competitor of N-formyl-Met-Leu-Phe for binding to FPR1 and inhibits migration, invasion, trans-endothelial migration of sarcoma cells and VEGF-triggered endothelial tube formation. When sarcoma cells were subcutaneously injected in nude mice, tumor size, intra-tumoral microvessel density, circulating tumor cells and pulmonary metastases were significantly reduced in animals treated daily with 6 mg/Kg RI-3 as compared to animals treated with vehicle only. Thus, RI-3 represents a promising lead for anti-metastatic drugs.
Neuronal Migration Depends on Intact Peroxisomal Function in Brain and in Extraneuronal Tissues (2003)

Functional peroxisome deficiency, as encountered in Zellweger syndrome, causes a specific impairment of neuronal migration. Although the molecular mechanisms underlying the neuronal migration defect are at present unknown, the excess of very long chain fatty acids in brain, a consequence of peroxisomalbeta-oxidation deficiency, has often been hypothesized to play a major role. The purpose of the present study was to investigate the contribution of peroxisomal dysfunction in brain as opposed to peroxisomal dysfunction in extraneuronal tissues to the migration defect. Peroxisomes were selectively reconstituted either in brain or liver of Pex5 knock-out mice, a model for Zellweger syndrome, by tissue-selective overexpression of Pex5p. We found that both rescue strains exhibited a significant correction of the neuronal migration defect despite an incomplete reconstitution of peroxisomal function in the targeted tissue. Animals with a simultaneous rescue of peroxisomes in both tissues displayed a pattern of neuronal migration indistinguishable from that of wild-type animals on the basis of cresyl violet staining and 5',3'-bromo-2'-deoxyuridine birth-dating analysis. These data suggest that peroxisomal metabolism in brain but also in extraneuronal tissues affects the normal development of the mouse neocortex. In liver-rescued mice, the improvement of the neuronal migration was not accompanied by changes in very long chain fatty acid, docosahexaenoic acid, or plasmalogen levels in brain, indicating that other metabolic factors can influence the neuronal migration process.
L'hyperthyroïdie sévère associée à la prise d'amodarone: une urgence chirurgicale (1995)

peer reviewed
Modeling a Hydraulic Response to a Contamination Event (2009)

In responding to contamination incidents that may occur in a water distribution network, a variety of actions (e.g., public notification and operational changes) can be pursued. A relatively common and effective operational response option utilized by water utilities to address water quality concerns is flushing. The effectiveness of flushing alternatives can be evaluated by modeling the water distribution system dynamics. Two approaches to modeling hydrant flushing as a hydraulic response are examined in this paper: a fixed flushing rate and flow emitters. In addition, the effects of knowing the source location and the expected contamination spread are explored. The paper generally demonstrates that the effectiveness of flushing depends on the accuracy with which the initial contaminant plume location is known. In modeling flushing as a response, use of flow emitters instead of fixed flow to model hydrant discharge should provide a more realistic description of system response to flushing.
Characterization of huJAM: evidence for involvement in cell-cell contact and tight junction regulation (2000)

Cell-cell interactions of the mucosal epithelia are important for the maintenance and establishment of epithelial barrier function. During events of inflammation, such cell-cell interactions are often disrupted, resulting in a leaky epithelial barrier, which in turn can lead to various inflammatory and infective dysfunctions. Human junctional adhesion molecule (huJAM), found on the mucosal epithelia and vascular endothelia of many major organ systems, is a membrane glycoprotein which resolves to a doublet band of approximately 40 and approximately 37 kDa under SDS-PAGE analysis, representing differentially glycosylated forms of the same protein. huJAM was localized to the lateral membrane of Caco-2 cells (a human colonic epithelial cell line) monolayers, in an area basolateral of the epithelial tight junctions (TJ). Through functional and biochemical assays, we show huJAM to be able to homotypically associate and to participate in TJ restitution after trypsin-EDTA disruption. Furthermore, we also observed a migration of huJAM expression toward areas of cell-cell contacts during events of cell adhesion and monolayer formation. These qualities makes huJAM a likely player in the regulation of cell-cell contacts and the subsequent formation of TJs.
OpenII (2010)

OpenII (openintegration.org) is a collaborative effort to create a suite of open-source tools for information integration (II). The project is leveraging the latest developments in II research to create a platform on which integration tools can be built and further research conducted. In addition to a scalable, extensible platform, OpenII includes industrial-strength components developed by MITRE, Google, UC-Irvine, and UC-Berkeley that interoperate through a common repository in order to solve II problems. Components of the toolkit have been successfully applied to several large-scale US government II challenges.
Influence of Enterococcus faecium SF68 Probiotic on Giardiasis in Dogs (2009)

Short-term treatment with E. faecium SF68 of dogs with chronic naturally acquired subclinical giardiasis fails to affect giardial cyst shedding or antigen content and does not alter innate or adaptive immune responses.
Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocations (1994)

The EVI1 gene encodes a zinc-finger, DNA-binding protein originally described as the transforming gene associated with a common ecotropic viral insertion site in myeloid leukemias. Previous studies demonstrated EVI1 expression in human leukemias in cases with 3q26 translocations, but not in normal blood or bone marrow. These studies also suggested an association between EVI1 expression and chromosome 7 deletion (del). Because of this association, we examined expression of EVI1 using RNA polymerase chain reaction (PCR) in patients with myelodysplastic syndromes (MDS) and acute leukemia with and without 3q26 translocations. EVI1 RNA was expressed in 29% of 34 (95% confidence interval, 20% to 50%) patients with the MDS subtypes refractory anemia (RA), refractory anemia with excess blasts (RAEB), or refractory anemia with excess blasts in transformation (RAEB-T). The vast majority of these cases occurred in patients with RAEB and RAEB-T. EVI1 expression was not detected in patients with chronic myelomonocytic leukemia (CMML), normal bone marrow or cord blood, or a variety of other hematologic malignancies. EVI1 RNA was detected in three of 18 patients with acute myelogenous leukemia (AML) and in two of four patients with acute promyelocytic leukemia (APL). Karyotypes showed that only one AML patient had karyotype 3q26 abnormalities, indicating that EVI1 expression is associated with cases that do not have structural abnormalities involving chromosome 3q26. These studies document for the first time the abnormal expression of EVI1 RNA by patients with MDS, and suggest an important role for EVI1 in the pathogenesis or progression of some myeloid malignancies.
Expression, crystallization and X-ray diffraction analysis of a complex between B7-H6, a tumor cell ligand for the natural cytotoxicity receptor NKp30, and an inhibitory antibody (2015)

Natural killer (NK) cells are essential components of the innate immune response to tumors and viral infections. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells. A mouse monoclonal antibody (17B1.3) against human B7-H6 has been developed (Kd = 0.2 µM) to investigate NKp30-mediated NK cell activation and to target tumors expressing B7-H6. Surprisingly, 17B1.3 blocks NK cell activation without interfering with the binding of B7-H6 to NKp30. Understanding the inhibitory mechanism of this antibody will require knowing the structure of 17B1.3 bound to B7-H6. The antigen-binding fragment (Fab) of 17B1.3 was expressed by in vitro folding from bacterial inclusion bodies. The extracellular domain of B7-H6 was produced by secretion from baculovirus-infected insect cells. Crystals of the Fab 17B1.3-B7-H6 complex grown by macro-seeding diffracted to 2.5 Å resolution and belonged to space group P2(1)2(1)2(1), with unit-cell parameters a = 89.6, b = 138.0, c = 171.4 Å, α = β = γ = 90°. Comparison of the Fab 17B1.3-B7-H6 structure with the known NKp30-B7-H6 structure will elucidate the inhibitory mechanism of 17B1.3.
Towards Formal Verification of Role-Based Access Control Policies (2008)

Specifying and managing access control policies is a challenging problem. We propose to develop formal verification techniques for access control policies to improve the current state of the art of policy specification and management. In this paper, we formalize classes of security analysis problems in the context of Role-Based Access Control. We show that in general these problems are PSPACE-complete. We also study the factors that contribute to the computational complexity by considering a lattice of various subcases of the problem with different restrictions. We show that several subcases remain PSPACE-complete, several further restricted subcases are NP-complete, and identify two subcases that are solvable in polynomial time. We also discuss our experiences and findings from experimentations that use existing formal method tools, such as model checking and logic programming, for addressing these problems.