gebhart/patrepeval huggingface dataset:
Experimental Evaluation of Distributor Technologies for Trickle-Bed Reactors (2013)

In this paper, different technologies of distributors for trickle bed reactors were compared, in terms of intrinsic performance of distribution and resistance to tray unlevelness. γ-ray tomography has first been used, in a large column unit, to visualize gas–liquid distribution just below several tray technologies. Results obtained show a better distribution performance under multiaperture chimney trays, in comparison with gas-lift and bubble cap systems. Then, a specific cold mock-up was designed in order to mimic tray tilt between two tray elements. Sensitivities to tray unlevelness of both gas-lift and multiaperture systems are comparable, far better than the one for the bubble cap system. Multiaperture chimneys have indeed excellent behavior at nominal conditions, while gas-lift technology is interesting for its ability to behave similarly over a large flow range. Considering those results, some guidelines are finally given for the choice of the distribution technology.
Depth-of-interaction recognition using optical filters for nuclear medicine imaging (2005)

This paper describes a depth-of-interaction recognition method that can be applied to radiation detectors for positron emission tomography. The proposed method uses optical filters to differentiate wavelength distribution of scintillation photons depending on crystal depth positions. Then the crystal of interaction can be identified with a multianode photodetector whose sensitive surface is partly covered with optical filters. A validation experiment was performed with a position sensitive photomultiplier. As a result, it was proved that the crystal depth of interaction was clearly identified for photoabsorption events.
Complexity Reduction Techniques Applied to The Compression of High Definition Sequences in Digital TV (2008)

Resumo-O H.264/AVC um codificador de modulac o de cdigo de pulso com estrutura hbrida em que so conectados mdulos preditivos e de transformac o. Neste trabalho propomos uma abordagem mais eficiente para a implementac o do mdulo de predic o, notavelmente o estgio mais complexo computacionalmente desse codificador. A idia testar apenas subconjunto de modos de predic o dominantes em vez de fazer o teste exaustivo de todos os modos recomendados pelo padro H
Biomedical polymers : molecular design to clinical applications (1993)

Part 1 Biomaterials for tissue engineering: design of synthetic polymeric structures for cell transplantation and tissue engineering. Part 2 Biomaterials for hard tissue applications: histological patterns of the tissue reaction to polymers in orthopaedic surgery. Part 3 Biomaterials for soft tissue, blood and cardiovascular applications: a new gas discharge process for preparation of non-fouling surfaces on biomaterials. Part 4 Biomaterials for drug delivery systems: a morphine-triggered delivery system useful in the treatment of heroin addiction. (Part contents - a full list of papers is available on request to the publisher).
10104 Students Recognition on Spectroscopic Education (2006)

At Department of Mechanical Engineering Tokyo University, about 90 students take the subject "Manufacturing Exercise" in one team. We divide the students into 2 classes, and in each class, 8 groups are constructed, 5 to 6 students belong to each group. Under the guidance of setup in the Optical understanding of principle Spectrum and study on diffraction Spectrum can be applied to the mechanical engineering in this paper the authors are reporting on Optical instrument in the students manufacturing Exercise
Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models (2019)

The alkylating agent platinum is first-line chemotherapy treatment for high-grade serous carcinomas (HGSC) of tubal-ovarian origin. Platinum compounds cause DNA damage and induce apoptotic cell death in the bulk tumor population. However, subpopulations of tumor cells may exhibit diverging behaviors from the bulk tumor due to an alternate stress response that diverts tumor cells from apoptotic death. In this study, we identified a salvage survival pathway in which G2-arrested tumor cells bypassed apoptosis and progressed through aberrant mitotic events to then emerge as a distinct subpopulation of viable large hyperploid cells but with uncertain long-term propagation potential. Platinum-induced large hyperploid cells were flow sorted and showed rare regrowth capacity as compared to their more proficiently regenerating non-hyperploid counterparts. However, detailed time-lapse microscopy provided direct evidence that these hyperploid cells were mitotically active and could divide successfully to produce viable daughter cells. The <i>hyperploid survival response</i> was observed across different cell lines and utilization of this survival pathway was dependent on the strength of the G2-M checkpoint. Conceivably, this salvage survival strategy may contribute to increased genomic diversity of the regenerating tumor cell line through a coupled hyperploidization and de-polyploidization process that may be relevant for drug resistance.
Improving quality and harvest period of protein crystals for structure-based drug design: effects of a gel and a magnetic field on bovine adenosine deaminase crystals (2003)

The overall crystal quality as well as the harvest period of bovine adenosine deaminase containing a zinc ion at the active centre has been compared in three different environments: crystallization as a control, crystallization with agarose gel and crystallization in a high magnetic field. In crystallization with agarose gel, the probability of obtaining high-quality crystals was somewhat increased, but the harvest period was elongated. On the other hand, in crystallization in a magnetic field, the probability of obtaining high-quality crystals was greatly increased. Furthermore, the harvest period for crystal growth in a magnetic field was much shorter than that with agarose gel.
Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62 (2015)

Atypical protein kinase C (aPKC) enzymes signal on protein scaffolds, yet how they are maintained in an active conformation on scaffolds is unclear. A myristoylated peptide based on the autoinhibitory pseudosubstrate fragment of the atypical PKCζ, zeta inhibitory peptide (ZIP), has been extensively used to inhibit aPKC activity; however, we have previously shown that ZIP does not inhibit the catalytic activity of aPKC isozymes in cells (Wu-Zhang, A. X., Schramm, C. L., Nabavi, S., Malinow, R., and Newton, A. C. (2012) J. Biol. Chem. 287, 12879-12885). Here we sought to identify a bona fide target of ZIP and, in so doing, unveiled a novel mechanism by which aPKCs are maintained in an active conformation on a protein scaffold. Specifically, we used protein-protein interaction network analysis, structural modeling, and protein-protein docking to predict that ZIP binds an acidic surface on the Phox and Bem1 (PB1) domain of p62, an interaction validated by peptide array analysis. Using a genetically encoded reporter for PKC activity fused to the p62 scaffold, we show that ZIP inhibits the activity of wild-type aPKC, but not a construct lacking the pseudosubstrate. These data support a model in which the pseudosubstrate of aPKCs is tethered to the acidic surface on p62, locking aPKC in an open, signaling-competent conformation. ZIP competes for binding to the acidic surface, resulting in displacement of the pseudosubstrate of aPKC and re-engagement in the substrate-binding cavity. This study not only identifies a cellular target for ZIP, but also unveils a novel mechanism by which scaffolded aPKC is maintained in an active conformation.
A Tunable Hybrid III-V-on-Si MOS Microring Resonator with Negligible Tuning Power Consumption (2016)

We demonstrate a novel hybrid microring resonator with an integrated III-V-on-Si metal-oxide-semiconductor (MOS) capacitor structure for essentially zero-power resonance tuning. Over 1,000,000,000 times better tuning efficiency than conventional thermal tuning approach has been achieved.
PUTTING THE URETER TO “REST”: THE EFFECTS OF NIFEDIPINE, KETOPROFEN, OR THE COMBINATION ON PHENYLEPHRINE ENHANCED PERISTALSIS IN AN EX VIVO INTRALUMINALLY PERFUSED PORCINE URETERAL MODEL (2008)

You have accessJournal of Urology1 Apr 2008PUTTING THE URETER TO “REST”: THE EFFECTS OF NIFEDIPINE, KETOPROFEN, OR THE COMBINATION ON PHENYLEPHRINE ENHANCED PERISTALSIS IN AN EX VIVO INTRALUMINALLY PERFUSED PORCINE URETERAL MODEL Ralph E Purdy, Stan Shelkovnikov, Scott M Summers, Jeffrey M Herz, Clark E Tedford, Geoffrey N Box, Michael K Louie, and Ralph V Clayman Ralph E PurdyRalph E Purdy More articles by this author , Stan ShelkovnikovStan Shelkovnikov More articles by this author , Scott M SummersScott M Summers More articles by this author , Jeffrey M HerzJeffrey M Herz More articles by this author , Clark E TedfordClark E Tedford More articles by this author , Geoffrey N BoxGeoffrey N Box More articles by this author , Michael K LouieMichael K Louie More articles by this author , and Ralph V ClaymanRalph V Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)61649-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "PUTTING THE URETER TO “REST”: THE EFFECTS OF NIFEDIPINE, KETOPROFEN, OR THE COMBINATION ON PHENYLEPHRINE ENHANCED PERISTALSIS IN AN EX VIVO INTRALUMINALLY PERFUSED PORCINE URETERAL MODEL." The Journal of Urology, 179(4S), p. 561 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 561 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Ralph E Purdy More articles by this author Stan Shelkovnikov More articles by this author Scott M Summers More articles by this author Jeffrey M Herz More articles by this author Clark E Tedford More articles by this author Geoffrey N Box More articles by this author Michael K Louie More articles by this author Ralph V Clayman More articles by this author Expand All Advertisement PDF DownloadLoading ...
ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis (2017)

Heparin-binding EGF-like growth factor (HB-EGF) plays an indispensable role in suppression of cell proliferation during mouse valvulogenesis. However, ligands of the EGF receptor (EGFR/ErbB1), including HB-EGF, are generally considered as growth-promoting factors, as shown in cancers. HB-EGF binds to and activates ErbB1 and ErbB4. We investigated the role of ErbB receptors in valvulogenesis <i>in vivo</i> using ErbB1- and ErbB4-deficient mice, and an <i>ex vivo</i> model of endocardial cushion explants. We show that HB-EGF suppresses valve mesenchymal cell proliferation through a heterodimer of ErbB1 and ErbB4, and an ErbB1 ligand (or ligands) promotes cell proliferation through a homodimer of ErbB1. Moreover, a rescue experiment with cleavable or uncleavable isoforms of ErbB4 in <i>ERBB4</i>-null cells indicates that the cleavable JM-A, but not the uncleavable JM-B, splice variant of ErbB4 rescues the defect of the null cells. These data suggest that the cytoplasmic intracellular domain of ErbB4, rather than the membrane-anchored tyrosine kinase, achieves this suppression. Our study demonstrates that opposing signals generated by different ErbB dimer combinations function in the same cardiac cushion mesenchymal cells for proper cardiac valve formation.
Additive Digital Casting: From Lab to Industry (2022)

Concrete construction harms our environment, making it urgent to develop new methods for building with less materials. Structurally efficient shapes are, however, often expensive to produce, because they require non-standard formworks, thus, standard structures, which use more material than is often needed, remain cheaper. Digital fabrication has the potential to change this paradigm. One method is Digital Casting Systems (DCS), where the hydration of self-compacting concrete is controlled on the fly during production, shortening the required setting time and reducing hydrostatic pressure on the formwork to a minimum. This enables a productivity increase for standard concrete production. More importantly, though, it enables a rethinking of formworks, as the process requires only cheap thin formworks, thus, unlocking the possibility to produce optimised structural members with less bulk material and lower environmental cost. While DCS has already proven effective in building structural members, this process faces the challenge of moving into industry. This paper covers the next steps in doing so. First, we present the benchmark and expectations set by the industry. Second, we consider how we comply with these requirements and convert our fast-setting self-compacting mortar mix into a coarser one. Third, we present the next generation of our digital processing system, which moves closer to the industrial requirements in terms of size and the control system. Finally, two prototypes demonstrate how DSC: (a) increases standard bulk production by 50% and (b) can be cast into ultra-thin formworks. We discuss the results and the short-term industrial concerns for efficiency and robustness, which must be addressed for such a system to be fully implemented in industry.
Microelectrospray (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
National survey of periventricular leukomalacia in Japan (1998)

It was roughly calculated that about 750 cases of CP with PVL occurred annually in Japan, thus accounting for about one-third of the total number of cases of CP.
Multi‐omics analyses reveal epigenomics basis for cotton somatic embryogenesis through successive regeneration acclimation process (2018)

Plant regeneration via somatic embryogenesis is time-consuming and highly genotype-dependent. The plant somatic embryogenesis process provokes many epigenetics changes including DNA methylation and histone modification. Recently, an elite cotton Jin668, with an extremely high regeneration ability, was developed from its maternal inbred Y668 cultivar using a Successive Regeneration Acclimation (SRA) strategy. To reveal the underlying mechanism of SRA, we carried out a genome-wide single-base resolution methylation analysis for nonembryogenic calluses (NECs), ECs, somatic embryos (SEs) during the somatic embryogenesis procedure and the leaves of regenerated offspring plants. Jin668 (R4) regenerated plants were CHH hypomethylated compared with the R0 regenerated plants of SRA process. The increase in CHH methylation from NEC to EC was demonstrated to be associated with the RNA-dependent DNA methylation (RdDM) and the H3K9me2-dependent pathway. Intriguingly, the hypomethylated CHH differentially methylated regions (DMRs) of promoter activated some hormone-related and WUSCHEL-related homeobox genes during the somatic embryogenesis process. Inhibiting DNA methylation using zebularine treatment in NEC increased the number of embryos. Our multi-omics data provide new insights into the dynamics of DNA methylation during the plant tissue culture and regenerated offspring plants. This study also reveals that induced hypomethylation (SRA) may facilitate the higher plant regeneration ability and optimize maternal genetic cultivar.
Memory Errors and Memory Safety: A Look at Java and Rust (2023)

We consider memory errors and memory safety in the cases of the Java and Rust programming languages. We also give a view of how type safety fits in.
Tetra-Thymidine Phosphorofluoridates via Tetra-Thymidine Phosphoro-selenoates: Synthesis and Stability (1999)

Abstract Tetra-thymidine phosphoroselenoates obtained via phosphoramidite methodology with bis(di-O,O-isopropyl phosphinothioyl)diselenide as oxidising reagent, under treatment with iodine and triethylamine tris(hydrofluoride) (TAF) provide a diastereomeric mixture of tetra-thymidine phosphorofluoridates whose hydrotytic stability was studied by HPLC.
Neurokinin-1 (NK-1) receptor is required in Clostridium difficile- induced enteritis. (1998)

Toxin A, a 308,000-Mr enterotoxin from Clostridium difficile, mediates antibiotic-associated diarrhea and colitis in humans. Injection of toxin A into animal intestine triggers an acute inflammatory response characterized by activation of sensory neurons and immune cells of the intestinal lamina propria, including mast cells and macrophages, and migration of circulating neutrophils in the involved intestinal segment. In this study we show that mice genetically deficient in the neurokinin-1 receptor are protected from the secretory and inflammatory changes as well as from epithelial cell damage induced by toxin A. The protective effect of neurokinin-1R deletion correlates with diminished intestinal levels of the cytokine TNF-alpha and its mRNA and the leukocyte enzyme myeloperoxidase. These results demonstrate a major requirement for substance P receptors in the pathogenesis of acute inflammatory diarrhea.
Optofluidic particle manipulation in a liquid-core/liquid-cladding waveguide (2012)

This paper describes a method for particle manipulation in a liquid-core/liquid-cladding optical waveguide system. Step-index and graded-index waveguides were modeled with consideration for, respectively, miscible and immiscible core and cladding fluids. The characteristic motions of four different particles with refractive indices of 1.59, 1.48, 1.37, and 1.22 were examined. The guided beam was assumed to be Gaussian in shape. Our results showed that high-refractive-index particles converged at the center of the core fluid due to a positive gradient force, whereas low-refractive-index particles converged at the flow periphery. The nonlinearity of the particle motion increased as the flow velocity and the guided beam waist decreased and the laser power and the particle size increased. The initial beam waist of the guided beam in the graded-index waveguide did not significantly affect the characteristics of the particle motion due to the effects of diffusion.
Use of Postprostatectomy Radiation Therapy at an NCI-Designated Comprehensive Cancer Center (2015)

A larger proportion of patients treated with RT for localized prostate cancer are now receiving PPRT. No increase was seen in the proportion of patients treated with adjuvant RT. Over time, patients with lower PSAs were referred for salvage RT.
Influence of Paravalvular Leakage after TAVR on Left Ventricular Work and Coronary Flow: An In-vitro Study (2019)

Objective: To assess the influence of paravalvular leakage (PVL) on stroke work and coronary flow (CF) after transcatheter aortic valve replacement in a pulse duplicator. Methods: A Medtronic CoreValve 29mm aortic valve was used for the measurements. The aortic root model featured three sinuses of valsalvae, two coronary arteries and a mechanism to induce progressive PVL at each of the sinuses. Pressure, flow and PV-loops were measured at normotensive conditions (no PVL, 5L/min cardiac output (CO), 100mmHg mean aortic pressure (MAP)) and at various degrees of PVL up to leakage rates considered severe in clinical routine. The PV loops allowed for the calculation of left ventricular work. Results: CO decreased steadily with increasing PVL up to a minimum of 3.4L/min at severe PVL at 40%. MAP decreased with increasing PVL (MAP 60mmHg at 40% PVL, p<0.01). The stroke work required to maintain normotensive conditions with PVL increased significantly with more severe leakage up to a maximum of 2.2J at 40% PVL (baseline 1.27J, p<0.01). Coronary flow decreased with increasing PVL by up to 33% and 43% for the left and right coronary artery, respectively, at 40% PVL. The location of the PVL with regards to the coronary ostia did not show any impact on CF. Readjusting the stroke of the pulse duplicator to normotensive conditions resulted in an increase of CF back to baseline values. Conclusions: The increased stroke work necessary to regain sufficient CO, CF and MAP when PVL is present puts additional strain on the left ventricle potentially promoting hypertrophy and subsequently heart failure. Effects of PVL location on CF such as the Venturi effect that have been described in literature were not seen.
Incidental prenatal detection of an Xp deletion using an anonymous primer pair for fetal sexing (2000)

We report on the incidental prenatal detection of an interstitial X-chromosomal deletion in a male fetus and his mother by fetal sexing with a primer pair recognizing an X-Y homologous locus (DXYS19), formerly unassigned on the X chromosome. The proband asked for prenatal diagnosis because of her elevated age and risk of Duchenne muscular dystrophy (DMD). Prior to molecular genetic testing for DMD, fetal sexing was carried out on DNA prepared from cultured amniocytes. PCR analysis revealed the expected Y-chromosomal product, but did not show the constitutive X-chromosomal fragment. The absence of the X-chromosomal fragment in the fetus and on one X chromosome of the mother was confirmed by Southern hybridization of HindIII restricted DNA with probe pJA1165 (DXYS19). DXYS19X was mapped to Xp22.3 by combining several approaches, including: (1) analysis of somatic cell hybrid lines containing different fragments of the human X chromosome; (2) Southern hybridization of a yeast artificial chromosome (YAC)-filter panel provided by the Resource Center/Primary Database (RZPD); (3) FISH analysis; and (4) re-evaluation of two patients with interstitial deletions in Xp22.3. The extent of the deletion in the fetus was estimated by further markers from Xp22.3 and found to include the STS gene. Mental retardation could not be excluded since some mentally retarded patients exhibit overlapping deletions.