gebhart/patrepeval huggingface dataset:
Differential Induction of Apoptosis in B16 Melanoma and EL‐4 Lymphoma Cells by Cytostatin and Bactobolin (1999)

Most solid tumor cells are less sensitive to apoptosis induced by anticancer drugs than hematopoietic cancer cells. However, the mechanisms of the different responses to apoptosis in these cell types remain unknown. To explore this question, we used B16 melanoma and EL-4 lymphoma cells as solid tumor- and hematopoietic cancer-derived cell lines, and examined the effects of two apoptosis inducers, cytostatin and bactobolin, on both cell lines. Apoptosis in B16 cells was induced strongly by bactobolin, but weakly by cytostatin. In contrast, apoptosis in EL-4 cells was induced strongly by cytostatin, but weakly by bactobolin. While caspase-3 was activated upon induction of apoptosis in both cell lines, Ac-DEVD-CHO, a specific inhibitor of caspase-3, suppressed only the apoptosis in B16 cells. In B16 cells, cyclins E, A, and B1 were decreased by strongly apoptosis-inducing bactobolin prior to apoptosis commitment, but cyclin E was not decreased by weakly apoptosis-inducing cytostatin. On the other hand, in EL-4 cells cyclins D1, E, A, and B1 were decreased by strongly apoptosis-inducing cytostatin prior to apoptosis commitment, but neither cyclin A nor B1 was decreased by weakly apoptosis-inducing bactobolin. These results indicate that the dependency of apoptosis induction on caspase activity is different between the two cell lines. Furthermore, there may be an inverse correlation between specific cyclins and apoptosis induction in the two cell lines.
ChemInform Abstract: Efficacy of C—N Coupling Reactions with a New Multinuclear Copper Complex Catalyst and Its Dissociation into Mononuclear Species. (2011)

Abstract A new air‐stable copper(I)‐pyridazine/rhenate hybrid complex is prepared and its activity is explored in C—N coupling.
Induced Chromosome Deletion in a Williams-Beuren Syndrome Mouse Model Causes Cardiovascular Abnormalities (2010)

The deletion of Eln in this Wbs mouse model results in lower gene expression, hypertension, reduced cyclic strain, and fragmented elastin sheets. The observation that the number of medial lamellar units is normal in Wbs deletion mice, which is in contrast to Eln(+/-) mice, suggests other genes may be involved in vascular development.
Supplementary Figure from Discovery of a Conditionally Activated IL-2 that Promotes Antitumor Immunity and Induces Tumor Regression (2023)

Supplementary Figure from Discovery of a Conditionally Activated IL-2 that Promotes Antitumor Immunity and Induces Tumor Regression
Lessons Learned from Designing Visualization Dashboards (2016)

A variety of visualization guidelines, principles, and techniques are available to help create a visualization-based dashboard, but few publications discuss the experience of designing dashboards in the real world. This article discuss the lessons learned from designing applications for small start-up companies and institutions. From their experience as visualization practitioners, the authors confirm the need for tailored and customizable approaches, emphasize the need for a quicker way to create functional prototypes, point out frequent misconceptions on the scope of a functional prototype, discuss how performance can affect prototyping, and discuss the resistance of industrial partners to involve their customers in requirements gathering.
Addition of 1-6 GlcNAc branching to the oligosaccharide attached to Asn 772 in the serine protease domain of matriptase plays a pivotal role in its stability and resistance against trypsin (2003)

beta1-6 GlcNAc branching, a product of N-acetylglucosaminyltransferase V (GnT-V), is a key structure that is associated with malignant transformations and cancer metastasis. Although a number of reports concerning tumor metastasis-related glycoproteins that contain beta1-6 GlcNAc branching have appeared, the precise function of beta1-6 GlcNAc branching on glycoproteins remains to be elucidated. We previously reported on the importance of beta1-6 GlcNAc branching on matriptase in terms of proteolytic degradation in tumor metastasis. We report here that matriptase purified from GnT-V transfectant (beta1-6 GlcNAc matriptase) binds strongly to L4-PHA, which preferentially recognizes beta1-6 GlcNAc branches of tri- or tetraantennary sugar chains, indicating that the isolated matriptase contains beta1-6 GlcNAc branching. The beta1-6 GlcNAc matriptase was resistant to autodegradation, as well as trypsin digestion, compared with matriptase purified from mock-transfected cells. Furthermore, N-glycosidase-F treatment of beta1-6 GlcNAc matriptase greatly reduced its resistance to degradation. An analysis of matriptase mutants that do not contain potential N-glycosylation sites clearly shows that the beta1-6 GlcNAc branching on N-glycans attached to Asn 772 in the serine protease domain plays a major role in trypsin resistance. This is the first example of a demonstration of a direct relationship between beta1-6 GlcNAc branching and a biological function at the protein level.
A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk (2017)

To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together with an additional 390,225 variants from exome sequence in up to 39,339 normoglycemic individuals from five ancestry groups. We identified a novel association between the coding variant (p.Pro50Thr) in AKT2 and fasting insulin, a gene in which rare fully penetrant mutations are causal for monogenic glycemic disorders. The low-frequency allele is associated with a 12% increase in fasting plasma insulin (FI) levels. This variant is present at 1.1% frequency in Finns but virtually absent in individuals from other ancestries. Carriers of the FI-increasing allele had increased 2-hour insulin values, decreased insulin sensitivity, and increased risk of type 2 diabetes (odds ratio=1.05). In cellular studies, the AKT2-Thr50 protein exhibited a partial loss of function. We extend the allelic spectrum for coding variants in AKT2 associated with disorders of glucose homeostasis and demonstrate bidirectional effects of variants within the pleckstrin homology domain of AKT2.
Dubna “Delta-Sigma” Experiment: Results Of Treatment And Analysis Of Statistics Accumulated In 2001 Data Taking Run On Energy Dependence Of ΔσL(np) (2003)

First Page
Robust Zero-Shot Cross-Domain Slot Filling with Example Values (2019)

Task-oriented dialog systems increasingly rely on deep learning-based slot filling models, usually needing extensive labeled training data for target domains. Often, however, little to no target domain training data may be available, or the training and target domain schemas may be misaligned, as is common for web forms on similar websites. Prior zero-shot slot filling models use slot descriptions to learn concepts, but are not robust to misaligned schemas. We propose utilizing both the slot description and a small number of examples of slot values, which may be easily available, to learn semantic representations of slots which are transferable across domains and robust to misaligned schemas. Our approach outperforms state-ofthe-art models on two multi-domain datasets, especially in the low-data setting.
Capacitance reduction effect using capping-layer removal process for porous low-k (k=2.5)/Cu system toward 45nm technology node (2007)

The Cu interconnects with porous SiOC-CVD (=p-SiOC, k=2.5) was successfully integrated into 45 nm technology node featuring an effective k-value (=k- <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">eff</sub> ) decreasing process. The decrease in k-eff was achieved by removing the capping layer on p-SiOC film and the damaged interface layer in p-SiOC using dry-etching process. Using this capping layer dry-etching process (=CEP), a 10% reduction in k- <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">eff</sub> and a highly improved line-to-line leakage as well as longer TDDB lifetime are obtained for 45 nm technology node with 140 nm pitch metallization.
Spectral modulation masking patterns reveal tuning to spectral envelope frequency (2007)

Auditory processing appears to include a series of domain-specific filtering operations that include tuning in the audio-frequency domain, followed by tuning in the temporal modulation domain, and perhaps tuning in the spectral modulation domain. To explore the possibility of tuning in the spectral modulation domain, a masking experiment was designed to measure masking patterns in the spectral modulation domain. Spectral modulation transfer functions (SMTFs) were measured for modulation frequencies from 0.25 to 14 cycles/octave superimposed on noise carriers either one octave (800-1600 Hz, 6400-12,800 Hz) or six octaves wide (200-12,800 Hz). The resulting SMTFs showed maximum sensitivity to modulation between 1 and 3 cycles/octave with reduced sensitivity above and below this region. Masked spectral modulation detection thresholds were measured for masker modulation frequencies of 1, 3, and 5 cycles/octave with a fixed modulation depth of 15 dB. The masking patterns obtained for each masker frequency and carrier band revealed tuning (maximum masking) near the masker frequency, which is consistent with the theory that spectral envelope perception is governed by a series of spectral modulation channels tuned to different spectral modulation frequencies.
Decompression Alone in the Setting of Adult Degenerative Lumbar Scoliosis and Stenosis: A Systematic Review and Meta-Analysis (2022)

Current literature on decompression alone in the setting of DLS is sparse and is not high quality, limited to patients with small magnitude of lumbar coronal Cobb angle, and heterogenous in the type of procedure performed. Based on available evidence, select patients with DLS who undergo decompression alone had minimal progression of Cobb angle, relatively low reoperation rate, and favorable patient-reported outcomes.
NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4 (2020)

Abstract Pancreatic ductal adenocarcinoma (PDAC) is an almost universally fatal malignancy and there is an urgent need for new therapeutic targets. PDAC cells harbor genetic alterations and display metabolic changes that render them vulnerable to perturbations in redox homeostasis. Peroxiredoxin 4 (PRDX4) supports redox homeostasis by metabolizing H 2 O 2 in the endoplasmic reticulum (ER). Based on functional genomics, we found that PDAC cell lines are dependent on PRDX4 for their growth and survival. We validated this dependency in established and primary PDAC cells, as well as 3D models and orthotopic xenografts. Cell death induced by PRDX4 depletion was accompanied by increased levels of reactive oxygen species (ROS), DNA damage and a DNA-PKcs-governed DNA damage response. As such, PRDX4 depletion also sensitized cells and tumors to ionizing radiation. The source of ROS that created a dependency on PRDX4 was attributed to NADPH oxidase 4 (NOX4), which localizes to the ER membrane. The functional requirement for PRDX4 was correlated with cellular NADPH levels across different models of PDAC and could be rescued by depletion of NOX4 or NADPH. As such, this study has identified NOX4 as a link between metabolic deregulation and ER-specific redox vulnerability in PDAC. Since PRDX4 is not an essential gene in normal tissues, our work also suggests that PRDX4 represents a novel therapeutic target for pancreatic cancer that may be particularly potent in combination with radiotherapy.
Adaptive SPECT (2008)

Adaptive imaging systems alter their data-acquisition configuration or protocol in response to the image information received. An adaptive pinhole single-photon emission computed tomography (SPECT) system might acquire an initial scout image to obtain preliminary information about the radiotracer distribution and then adjust the configuration or sizes of the pinholes, the magnifications, or the projection angles in order to improve performance. This paper briefly describes two small-animal SPECT systems that allow this flexibility and then presents a framework for evaluating adaptive systems in general, and adaptive SPECT systems in particular. The evaluation is in terms of the performance of linear observers on detection or estimation tasks. Expressions are derived for the ideal linear (Hotelling) observer and the ideal linear (Wiener) estimator with adaptive imaging. Detailed expressions for the performance figures of merit are given, and possible adaptation rules are discussed.
Chromaffin Cell Allograft for Cancer Pain Management (1999)

Preliminary clinical trials reported with adrenal medullary transplants into the CSF for irreductible cancer pain were contradictory. The objective of these phase II study is to confirm the faisability and to evaluate the analgesic activity effects of these approach. The prospective study concern 20 allofrafts for 15 irreductible cancer pain, after failure of oral opioids. All the patients were treated by daily intrathecal (I-Th) morphine administration. The mean follow-up is 92 days (15-365). The analgesic effects are interpreted in function of 3 parameters: pain intensity score (from 0 to 10), activity pattern and complementary narcotic intake. The results were excellent (pain score: 0-1, complete interruption of I-Th morphine) in 5 cases; good (pain score <2, diminution of I-Th morphine) in 2 cases; moderate (pain score < 3, stability of I-Th morphine) in 4 cases; and evaluated as failure (pain > 3, increase of I-Th morphine) in 3 cases. Clinical data...
Beyond Output Voting: Detecting Compromised Replicas using Behavioral Distance (2018)

Many host-based anomaly detection techniques have been proposed to detect code-injection attacks on servers. The vast majority, however, are susceptible to “mimicry” attacks in which the injected code masquerades as the original server software (including returning the correct service responses) while conducting its attack. In this paper we present a novel architecture to detect mimicry attacks using “behavioral distance”, by which two diverse replicas processing the same inputs are continually monitored to detect divergence in their low-level (system-call) behaviors and hence potentially the compromise of one of them. We detail the design and implementation of our architecture, which takes advantage of virtualization to achieve its goals efficiently. We apply our system to implement intrusion-tolerant web and game servers, and through trace-driven simulations demonstrate that our approach can achieve low false-alarm rates and moderate performance costs even when tuned to detect stealthy mimicry attacks.
IMMU-51. THE COMBINATION OF CCR2 ANTAGONIST AND PD-1 BLOCKADE PROLONGS SURVIVAL IN IMMUNE CHECKPOINT INHIBITOR RESISTANT GLIOMAS (2018)

Immuno-therapy directed at the PD-1/PD-L1 axis has produced significant treatment advances in various human cancers. Unfortunately, this progress has not extended to glioblastoma, with recent clinical trials failing to show efficacy of anti-PD-1 monotherapy in recurrent tumors. Commonly employed murine glioma models exhibit varied responsiveness to anti-PD-1 monotherapy, e.g. GL261 gliomas are sensitive while KR158 tumors are resistant. Previously, we reported that combining PD-1 blockade with either chemokine receptor CCR2 deficiency or a CCR2 antagonist improved survival over anti-PD-1 monotherapy in GL261 gliomas. This was associated with reduced numbers of MDSCs within tumors. The current study evaluated the combination of PD-1 blockade and a novel CCR2 antagonist in anti-PD-1 resistant gliomas. Determine if combination anti-PD-1/CCR2 antagonist therapy is an effective treatment in anti-PD-1 insensitive gliomas. Overall survival and immune cell characteristics were determined in KR158 and 005GSC gliomas established in either CCR2 deficient or wild type mice treated with CCR2 antagonist (CCX872) and/or PD-1 blockade. CCR2 deficiency unmasked an anti-PD-1 survival benefit in KR158 glioma-bearing mice. CCX872 increased median survival as a monotherapy in KR158 tumor-bearing animals, and significantly increased median and durable overall survival when combined with anti-PD-1. In 005GSC tumors, the combination of CCX872 and anti-PD-1 prolonged median survival time. Increases in overall CCR2+ cells and CD11b+/Ly6Chi myeloid derived suppressor cells (MDSC, known to be CCR2+) were evident in the bone marrow of CCR2-deficient mice. Additionally, these mice exhibited decreased MDSCs within established gliomas. The data demonstrate CCX872/anti-PD-1 synergize to increase survival in clinically relevant glioma models via reduced MDSC infiltration, resulting in a tumor microenvironment favorable for anti-PD-1 efficacy. The combination of CCX872 and anti-PD-1 is effective in clinically relevant murine glioma models, providing a basis on which to progress this novel combinatorial treatment toward early phase human trials.
Collisional charging of interstellar grains (1987)

Collisional charging of small interstellar particles is reexamined, including effects due to electrostatic polarization of grains by the electric fields of approaching charged particles. The interaction potentials and resulting energy-dependent collisional cross sections are discussed and used to obtain the collisional charging rate for grains of specified charges in a thermal plasma. The probability distribution of the grain charges is obtained, and the application of the results to the interstellar medium is illustrated by considering the power-law grain size distribution of Mathis, Rumpl, and Nordsieck (1977). It is found that dust grains with such a size distribution can contribute appreciably to the recombination of metal ions in dark clouds.
Twentieth-Century Romance and Gothic Writers (1982)

ABBOTT, Alice. Pseudonym for Kathryn Borland, née Kilby, and Helen Ross Speicher, née Smith. Also write as Jane Land, and Jane and Ross Land. BORLAND, Kathryn. American. Born in Pullman, Michigan, 14 August 1916. Educated at Butler University, Indianapolis, B.S. 1937. Married James Borland in 1942; one son and one daughter. Editor, North Side Topics weekly newspaper, Indianapolis, 1939–42. Agent: Jay Garon-Brooke Associates, 415 Central Park West, 17D, New York, New York 10025. Address: R.R. 3, South Maish Road, Frankfort, Indiana 46041, U.S.A. SPEICHER, Helen Ross. American. Born in Indianapolis, Indiana, 14 September 1915. Educated at Butler University, Indianapolis, B.A. in journalism (magna cum laude) 1937. Married Kenneth E. Speicher in 1941; three sons and one daughter. Editor, International Typographical Union, Indianapolis, 1937–41; editor of plant magazine, International Harvester, Indianapolis, 1942–44. Address: R.R. 2, Box 490, Indianapolis, Indiana 42680, U.S.A.
FY11 Report on Metagenome Analysis using Pathogen Marker Libraries (2011)

A method, sequence library, and software suite was invented to rapidly assess whether any member of a pre-specified list of threat organisms or their near neighbors is present in a metagenome. The system was designed to handle mega- to giga-bases of FASTA-formatted raw sequence reads from short or long read next generation sequencing platforms. The approach is to pre-calculate a viral and a bacterial "Pathogen Marker Library" (PML) containing sub-sequences specific to pathogens or their near neighbors. A list of expected matches comparing every bacterial or viral genome against the PML sequences is also pre-calculated. To analyze a metagenome, reads are compared to the PML, and observed PML-metagenome matches are compared to the expected PML-genome matches, and the ratio of observed relative to expected matches is reported. In other words, a 3-way comparison among the PML, metagenome, and existing genome sequences is used to quickly assess which (if any) species included in the PML is likely to be present in the metagenome, based on available sequence data. Our tests showed that the species with the most PML matches correctly indicated the organism sequenced for empirical metagenomes consisting of a cultured, relatively pure isolate. These runs completed in 1 minute to 3 hours on 12 CPU (1 thread/CPU), depending on the metagenome and PML. Using more threads on the same number of CPU resulted in speed improvements roughly proportional to the number of threads. Simulations indicated that detection sensitivity depends on both sequencing coverage levels for a species and the size of the PML: species were correctly detected even at ~0.003x coverage by the large PMLs, and at ~0.03x coverage by the smaller PMLs. Matches to true positive species were 3-4 orders of magnitude higher than to false positives. Simulations with short reads (36 nt and ~260 nt) showed that species were usually detected for metagenome coverage above 0.005x and coverage in the PML above 0.05x, and detection probability appears to be a function of both coverages. Multiple species could be detected simultaneously in a simulated low-coverage, complex metagenome, and the largest PML gave no false negative species and no false positive genera. The presence of multiple species was predicted in a complex metagenome from a human gut microbiome with 1.9 GB of short reads (75 nt); the species predicted were reasonable gut flora and no biothreat agents were detected, showing the feasibility of PML analysis of empirical complex metagenomes.
Lossless High-speed Silicon Photonic MZI switch with a Micro-Transfer-Printed III-V amplifier (2022)

We demonstrate an array of C-band high-speed silicon MZI switches with integrated III-V amplifiers on the imec iSiPP50G platform using micro-transfer printing. The integrated amplifiers exhibit 10 dB optical gain which enables lossless switching and facilitates cross-talk suppression of the switches.
Phase Locked System for Dual Comb Molecular Spectroscopy at 2-6 µm Based on Tm-fiber Laser (2014)

We demonstrate phase-coherent, frequency-stabilized dual-comb system at 2μm, extendable to mid-IR via phase-coherent frequency conversion in a doubly-resonant GaAs OPO. Results of dual-comb molecular spectroscopy with ~1M spectral points taken in ~1ms will be presented.
Detecting Chronic Critics Based on Sentiment Polarity and Userâ€™s Behavior in Social Media (2013)

There are some chronic critics who always complain about the entity in social media. We are working to automatically detect these chronic critics to prevent the spread of bad rumors about the reputation of the entity. In social media, most comments are informal, and, there are sarcastic and incomplete contexts. This means that it is difficult for current NLP technology such as opinion mining to recognize the complaints. As an alternative approach for social media, we can assume that users who share the same opinions will link to each other. Thus, we propose a method that combines opinion mining with graph analysis for the connections between users to identify the chronic critics. Our experimental results show that the proposed method outperforms analysis based only on opinion mining techniques.
Multiple beam antenna based on a parallel plate waveguide continuous delay lens beamformer (2016)

International audience
ChemInform Abstract: A Biomimetic Route to the Ergot Derailment Products, the Clavicipitic Acids. (1986)

Abstract Es wird ein biomimetischer Weg zu den Clavicipitinsäuren beschrieben.
Power management of the third generation intel core micro architecture formerly codenamed ivy bridge (2012)

This article consists of a collection of slides from the author's conference presentation on Ivy Bridge, power management applications of the third generation core Intel micro architecture. Some of the specific topics discussed include: an overview of the Ivy Bridge architecture and supported applications; power scaling and management facilities; core product features; power efficiency; voltage control and optimization technqiues; power sharing capabilities; and system architecture.