gebhart/patrepeval huggingface dataset:
Investigation Of A Laser-controlled, Copper-doped GaAs Closing And Opening Switch For Pulsed Power Applications (2005)

This paper describes the recent power scaling of the Bulk Optically Controlled Semiconductor Switch (BOSS). The processes of persistent photoconductivity followed by photo-quenching have been demonstrated in copper-compensated, silicon-doped, semi-insulating GaAs (GaAs:Cu:Si). These processes allow a switch to be developed which can be closed by the application of one laser pulse and opened by the application of a second laser pulse of longer wavelength. The high-power switching results indicate that the BOSS device will operate at multi-megawatt power levels. The results of our power scaling effort have suggested improvements to the basic BOSS design that will allow us to achieve reliable operation at high power levels.
Supplementary Figure 7 from CD4<sup>+</sup> T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8<sup>+</sup> T Lymphocytes (2023)

Supplementary Figure 7 from CD4&lt;sup&gt;+&lt;/sup&gt; T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8&lt;sup&gt;+&lt;/sup&gt; T Lymphocytes
Ultrastructural immunocytochemical localization of hormones in human pituitary adenomas (1985)

peer reviewed
Covalent Triazine Framework Nanoparticles via Size‐Controllable Confinement Synthesis for Enhanced Visible‐Light Photoredox Catalysis (2020)

For metal-free, organic conjugated polymer-based photocatalysts, synthesis of defined nanostructures is still highly challenging. Here, we report the formation of covalent triazine framework (CTF) nanoparticles via a size-controllable confined polymerization strategy. The uniform CTF nanoparticles exhibited significantly enhanced activity in the photocatalytic formation of dibenzofurans compared to the irregular bulk material. The optoelectronic properties of the nanometer-sized CTFs could be easily tuned by copolymerizing small amounts of benzothiadiazole into the conjugated molecular network. This optimization of electronic properties led to a further increase in observed photocatalytic efficiency, resulting in total an 18-fold enhancement compared to the bulk material. Full recyclability of the heterogeneous photocatalysts as well as catalytic activity in dehalogenation, hydroxylation and benzoimidazole formation reactions demonstrated the utility of the designed materials.
Integrated sensor biopsy device for real time tissue metabolism analysis (2018)

Current methods for guiding cancer biopsies rely almost exclusively on images derived from X-ray, ultrasound, or magnetic resonance, which essentially characterize suspected lesions based only on tissue density. This paper presents a sensor integrated biopsy device for in situ tissue analysis that will enable biopsy teams to measure local tissue chemistry in real time during biopsy procedures, adding a valuable new set of parameters to augment and extend conventional image guidance. A first demonstrator integrating three chemical and biochemical sensors was tested in a mice strain that is a spontaneous breast cancer model. In all cases, the multisensory probe was able to discriminate between healthy tissue, the edge of the tumor, and total insertion inside the cancer tissue, recording real-time information about tissue metabolism.
Wave Equation Processing and Imaging of Marine Multicomponent Data Beyond Traditional RTM (2014)

Summary Methods for wavefield injection are used in for instance reverse time extrapolation of shot gathers in reverse time migration. We show that by carefully considering the models used for wavefield injection, a number of long-standing problems in marine seismic data processing and imaging can be solved using conventional time-domain finite-difference propagators. The wavefield injection methodology requires pressure and particle velocity data such as multicomponent towed marine or seabed seismic recordings. In this paper we outline and demonstrate a number of important applications including wavefield separation (deghosting), direct wave removal, source signature estimation and reverse time migration using both primaries and multiples.
Identification of α-Fe in High-Silica Zeolites on the Basis of ab Initio Electronic Structure Calculations (2017)

α-Fe is the precursor of the reactive Fe<sup>IV</sup>═O core responsible for methane oxidation in Fe-containing zeolites. To get more insight into the nature and stability of α-Fe in different zeolites, the binding of Fe(II) at six-membered-ring cation exchange sites (6MR) in ZSM-5, zeolite beta, and ferrierite was investigated using DFT and multireference ab initio methods (CASSCF/CASPT2). CASPT2 ligand field (LF) excitation energies of all sites were compared with the experimental DR-UV-vis spectra reported by Snyder et al. From this comparison it is concluded that the 16000 cm<sup>-1</sup> band of α-Fe, observed in all three zeolites, can uniquely be assigned to a high-spin square-planar (SP) Fe(II) located at a 6MR with an Al-Si-Si-Al sequence, where the Al atoms are positioned opposite in the ring and as close to each other as possible. The stability of such conformations is also confirmed by the binding energies obtained from DFT. The bands at 10000 cm<sup>-1</sup> in the experimental spectra, assigned to spectator Fe(II), are attributed to six-coordinated trigonal-prismatic Fe(II) species, as calculated for the γ-site in ZSM-5. The entatic effect of the zeolite lattice on the stability of the SP sites was investigated by making use of the unconstrained Fe(II) model complex FeL<sub>2</sub> (with L = [Al(OH)<sub>4</sub>]<sup>-</sup>). The SP conformer is approximately 2 kcal/mol more stable than the tetrahedral form, indicating that the SP coordination environment of α-Fe is not imposed by the zeolite lattice but rather electronically preferred by Fe(II) in the environment of four O ligands. A significant contribution to the stability of the SP conformer is provided by mixing of the doubly occupied 3d<sub>z<sup>2</sup></sub> orbital with the higher lying 4s.
6.4: Ultra‐High Gas Barrier Films Based on a Few Barrier Layer Stack Fabricated by a Wet Coating and a Plasma Assisted Surface Modification (2014)

Abstract We have developed ultra‐high gas barrier films fabricated by wet coating technologies of barrier‐precursor and plasma assisted surface modifications. Owing to efficient coverage of wet process, our gas barrier films achieved 10 −5 g·m −2 ·day −1 under 40 °C, 90%RH by only a few layer stack of the barrier layers.
Increased Serum Klotho With Age-Related Aortic Stiffness and Peripheral Vascular Resistance in Young and Middle-Aged Swine (2020)

The anti-aging function of Klotho gene has been implicated in age-related diseases. The physiological importance of Klotho in the progression of arterial stiffness with aging, however, remains unclear. The goal of this study is to determine the correlation of circulating Klotho with early age-related aortic stiffening and peripheral hemodynamics. We measured serum Klotho levels in a group of pigs with age ranges of 1.5-9 years and investigated the relationship between Klotho levels and biomarkers of aortic stiffening with aging, including aortic pulse wave velocity (PWV), augmentation index (AIx), and pulse pressure (PP). The effects of aortic stiffening on peripheral vascular resistance, compliance, and function were also evaluated. We found that increased aortic stiffness occurred at middle age (>5 years old), as evidenced by an increase in PWV and AIx (<i>p</i> < 0.001), but with no changes in blood pressure and PP. With advancing age, increased femoral vascular resistance positively correlated with aortic PWV and AIx (<i>p</i> < 0.01). No significant difference in endothelium function and arterial compliance for femoral and small peripheral arteries was observed between young and middle-aged groups. The serum Klotho levels were lower in young and higher in middle-aged pigs (<i>p</i> < 0.001), and a positive correlation was found between Klotho and aortic PWV, AIx, and femoral vascular resistance (<i>p</i> < 0.01). Our findings suggest that early-aged aortic stiffening has adverse effect on peripheral hemodynamics, independent of blood pressure levels. Elevated Klotho secretion was associated with increased aortic stiffness and peripheral vascular resistance with aging.
Taq1A polymorphism in patients with bipolar disorder: A candidate gene study based on the dopamine hypothesis (2023)

This study explored the pathophysiology of bipolar disorder (BD) and schizophrenia (SZ) by examining the associations between the two disorders and single nucleotide polymorphisms (SNPs) involved in the dopamine signaling system. This was a case-controlled, exploratory, and multicenter study. A total of 1048 patients with BD (495 male; mean age, 49.6 ​± ​15.0 years), 2106 patients with SZ (1159 male, 49.6 ​± ​15.0 years), and 2240 healthy controls (HCs) (917 male, 42.3 ​± ​14.2 years) were included, and all the volunteers were Japanese. SNPs at tyrosine hydroxylase rs10770141 ​C-824T, catechol-O-methyltransferase rs4680 ​G/A(Val158Met), dopamine receptor D2 gene (DRD2) rs1799732 -141C Ins/Del, and DRD2/ANKK1 (Taq1A) rs1800497 ​C/T were examined. Binomial logistic regression analyses were performed to analyze the four SNPs, age, and sex. C allele and heterozygous CT in Taq1A were associated with an increased risk of BD. A comparison of the BD and HC groups revealed a significant association between heterozygous CT in Taq1A and BD in female participants. Heterozygous CT in Taq1A showed a significant association with BD as compared to SZ. DRD2 Taq1A polymorphism (CT heterozygotes) is associated with a high risk of BD in the Japanese population, particularly in females. DRD2 genetic predisposition in the dopamine signaling system and sex-specific factors may be associated with the pathophysiology of BD.
Drug-Nucleic Acid Interactions at the Molecular Level (2018)

High resolution crystallography of drug-Deoxyribonucleic acid (DNA) complexes with short-defined oligonucleotides, biophysical and biochemical DNA binding studies, and computer modeling complement each other in providing a comprehensive picture of DNA interactions. Interaction of small molecules with DNA can involve covalent bonding to DNA or non-covalent binding in the grooves or insertion between the base-pairs of DNA. The most detailed structural information about intercalation comes from X-ray crystal structure determination of DNA-intercalator complexes, involving simple oligonucleotides of defined sequence. Crystal structures of dinucleoside-intercalator complexes have provided conformational details of intercalation at the atomic level. Two alternative approaches that complement X-ray crystallography are biochemical techniques and computer graphics. Among the various biochemical techniques, footprinting methodology provides high resolution information about preferred DNA-ligand binding sites. Computer graphics are being used increasingly in studying ligand receptor binding. A major advantage of the method is that it enables rapid visualization of drug-DNA interactions.
Effects of stimulation parameters and electrode location on thresholds for epidural stimulation of cat motor cortex (2011)

Epidural electrical stimulation (ECS) of the motor cortex is a developing therapy for neurological disorders. Both placement and programming of ECS systems may affect the therapeutic outcome, but the treatment parameters that will maximize therapeutic outcomes and minimize side effects are not known. We delivered ECS to the motor cortex of anesthetized cats and investigated the effects of electrode placement and stimulation parameters on thresholds for evoking motor responses in the contralateral forelimb. Thresholds were inversely related to stimulation frequency and the number of pulses per stimulus train. Thresholds were lower over the forelimb representation in motor cortex (primary site) than surrounding sites (secondary sites), and thresholds at sites <4 mm away from the primary site were significantly lower than at sites >4 mm away. Electrode location and montage influenced the effects of polarity on thresholds: monopolar anodic and cathodic thresholds were not significantly different over the primary site, cathodic thresholds were significantly lower than anodic thresholds over secondary sites and bipolar thresholds were significantly lower with the anode over the primary site than with the cathode over the primary site. A majority of bipolar thresholds were either between or equal to the respective monopolar thresholds, but several bipolar thresholds were greater than or less than the monopolar thresholds of both the anode and cathode. During bipolar stimulation, thresholds were influenced by both electric field superposition and indirect, synaptically mediated interactions. These results demonstrate the influence of stimulation parameters and electrode location during cortical stimulation, and these effects should be considered during the programming of systems for therapeutic cortical stimulation.
SAR Studies and Rational Semisynthetic Modifications of Manzamine A for Anti-Malarial Activity (2008)

Malaria is a serious infectious disease causing high annual mortality rates, in particular due to growing in international tourism to infected areas. Manzamine A, is the first representative of the manzamine alkaloids and bears a unique multi-heterocyclic ring system attached to a β-carboline moiety. Manzamine A shows potent activity as an antimalarial agent however its toxicity reduces its potential as a drug candidate. Quaternary carbolinium salts have been shown to have better antimalarial activity and less cytotoxicity than electronically neutral β-carbolines [1]. Quaternary carbolinium salts of manzamine A were synthesized and evaluated for their antiplasmodial activity. Methylation of manzamine A was performed using methyl trifluoromethanesulfonate in two different molar ratios to afford 2-N-methylmanzamine A (1) and 2-N,12-O-dimethylmanzamine A (2). The structures of 1 and 2 were established utilizing high resolution ESI-MS, 1H-NMR, 13C-NMR and HMBC, HMQC. Resulting bioactivity data showed that 1 and 2 had low cytotoxicity in Vero cells (> 8237.8 µM) compared to manzamine A (IC50 = 364.5 µM) and however both analogs 1 and 2 were less potent (IC50 = 319.3 and 1557.6 µM respectively) than manzamine A (IC50 = 8.2 µM) against Plasmodium falciparum. Acknowledgements: This work was supported by the Public Health Service, grant number R29 AI 36596-01A1 from the National Institute of Allergy and Infectious Diseases, and, in part, by the Center for Disease Control, Cooperative Agreement No. U50/CCU418839 (M.A.A.). Anti-malarial assays were conducted by John Trott. Additional support through the Ministry of Scientific Research and Higher Education – Egypt. References: [1] Takasu K, et al. (2004) Bioorganic & Medicinal Chemistry Letters 14: 1689–1692.
Supplementary Table and Supplementary Figures S1-S7 from Pomalidomide Alters Pancreatic Macrophage Populations to Generate an Immune-Responsive Environment at Precancerous and Cancerous Lesions (2023)

&lt;p&gt;Supplementary Table 1: Table with antibodies and dilutions used Supplementary Figure S1: Treatment scheme and analyses of stroma Supplementary Figure S2: Additional analyses of cell death and cell proliferation Supplementary Figure S3: Presence of Ym1+ macrophage and IL-13 in PanIN areas Supplementary Figure S4: Additional data on the role of IRF4 in macrophage polarization Supplementary Figure S5: Presence of macrophage-secreted factors and T cells Supplementary Figure S6: Treatment scheme and analyses of presence of immune cells Supplementary Figure S7: Blood counts and coagulation profile&lt;/p&gt;
호텔기업의 내부마케팅이 고객지향성과 경영성과에 미치는 영향 - 부산지역 특급호텔을 중심으로 - (2014)

본 연구는 호텔기업의 종사원들이 고객 지향적이고 높은 수준의 서비스제공을 위해 중요한 역할을 하는 내부마케팅을 규명하고, 내부마케팅이 호텔종사원의 고객지향성에 어떠한 영향을 미치는지와 호텔기업의 경영성과에 어떠한 영향을 미치는지를 파악하여 호텔기업이 나아가야 할 방향을 제시하고자 하였다. 본 연구의 조사대상은 부산지역 특급호텔의 고객접점에서 업무하는 종사원으로서 이들은 고객에게 직접 서비스를 제공하는 부서소속으로 선정하였다. 설문지는 총 300부를 배포하여 최종분석에 사용된 설문지는 266부였다. 본 연구에서는 빈도분석, 신뢰도 분석 및 요인분석을 통한 타당성 검증과 변수들과의 영향관계 확인을 위하여 회귀분석을 활용하였다.
연구결과는 첫째, 호텔기업의 내부마케팅은 종사원의 고객지향성에 부분적으로 유의한 정(+)의 영향을 미치는 것으로 나타났다. 둘째, 호텔기업의 내부마케팅은 경영성과의 모든 요인이 유의한 정(+)의 영향을 미치는 것으로 나타났다. 셋째, 호텔종사원의 고객지향성은 호텔기업의 경영성과에 유의한 정(+)의 영향을 미치는 것으로 분석되었다. 이러한 연구결과는 호텔기업의 내부마케팅전략수립에 시사점을 제공할 것으로 판단된다.
Transmission RZ de 40x40 Gbit/s sur 3 pas de 40 dB de Fibre Standard avec 27.4 dB de Gain Raman contra-propagatif et un EDFA de 27 dBm (2004)

session V « Systèmes de télécommunication » [502]
A higher anti-Müllerian hormone level is associated with an increased chance of pregnancy in patients undergoing controlled ovarian stimulation and intrauterine insemination (2014)

Anti-Müllerian hormone (AMH) level has been found to be a useful marker of ovarian reserve, and a predictor of poor and hyper-responses in patients undergoing controlled ovarian stimulation (COS). The study aimed to determine the association of serum AMH level with achieving pregnancy in patients undergoing COS with intrauterine insemination. The cross-sectional study investigated 204 patients who underwent COS with intrauterine insemination at the Obstetrics and Gynecology Department of Taipei Medical University Hospital, from January 2011 to March 2012. The medical records of these patients were reviewed, and serum AMH levels were evaluated for association with successful clinical pregnancy. The AMH level in the patients who achieved clinical pregnancy was significantly higher than in patients who did not (median 2.7 vs 2.0 ng/ml, p = 0.005). Controlling for factors affecting infertility, AMH level had a significant independent influence on outcome; a higher AMH level was associated with a decreased risk of a non-pregnant outcome (odds ratio, OR = 0.895, p = 0.026). In patients undergoing COS and intrauterine insemination, a low AMH level is associated with a decreased chance of a clinical pregnancy, and this association remains irrespective of the presence or absence of endometriosis.
Toward Real-Time SQM for WAAS: Improved Detection Techniques (2003)

involves multipath mitigation techniques and satellite signal anomalies. Todd Walter received his B. S. in physics from
UV and DSC Analyses of Suspensions of Mixtures of Phosphatidylcholine and a Fatty Acid Having a Diene Group (1991)

Abstract The aqueous suspensions of the mixtures of a phosphatidylcholine (1,2-Bis[(2E,4E)-2,4-octadecadienoyl]-sn-glycero-3-phosphocholine (1b) and 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine (1a)) with a fatty acid ((2E,4E)-2,4-octadecadienoic acid and octadecanoic acid), having a diene chromophore were analyzed by DSC and UV measurements. The phase transition was dependent on the composition of the lipid mixtures. The UV spectral change of the diene chromophore of a fatty acid for the 1a mixtures corresponded well with the phase transition determined by DSC analyses, but not for the 1b mixtures.
Broad Spectrum Antioxidant Properties of 20 Indian Medicinal Plants (2016)

Antioxidant properties of methanol extracts of 20 plants were studied by four different assays over a range of concentrations (12.5–400 µg mL−1), and compared with standard antioxidants’ ascorbic acid and butylated hydroxytoluene. Ascorbic acid–equivalent antioxidant activity of extracts by the phosphomolybdenum method ranged from 392.8 to 2942.7 µmoles g−1 at 400 µg mL−1, whereas DPPH radical scavenging was between 30.9% and 95.2%; extracts also showed strong activity by FRAP and CUPRAC assays. The extracts demonstrated dose-dependent activity and strong correlation between antioxidant activities and total phenolics. Total phenolic content was the highest in Syzygium aromaticum (279 mg GAE g−1) and the lowest in Sesame indicum (28.16 mg GAE g−1).
Metabolic syndrome and the risk of urothelial carcinoma of the bladder: a case-control study (2015)

This study supports a positive association between the MetS and bladder cancer risk.
Spectroscopy Of Nitrenes Bound To ∝-Chymotrypsin (1988)

Reaction of &prop;-chymotrypsin with various aryl azido acylimidazoles leads to covalent attachment of the aryl azide photoaffinity label. Photolysis of the polycrystalline enzyme or a frozen solution of the enzyme at 77K leads to intense EPR signals of the triplet nitrenes. The position of the EPR resonance fields and the decay kinetics can be interpreted in terms of binding of the label within or outside the binding pocket of the enzyme.
First-order transition atTCin the orthomanganites (1996)

The orthomanganites ${L}_{0.7}{A}_{0.3}\mathrm{Mn}{\mathrm{O}}_{3}$, $L=\mathrm{r}\mathrm{a}\mathrm{r}\mathrm{e}\ensuremath{-}\mathrm{e}\mathrm{a}\mathrm{r}\mathrm{t}\mathrm{h}\phantom{\rule{0ex}{0ex}}\mathrm{o}\mathrm{r}\phantom{\rule{0ex}{0ex}}\mathrm{Y}$ and $A=\mathrm{alkaline}\mathrm{earth}$, exhibit a first-order transition at a ferromagnetic Curie temperature ${T}_{C}$, where ${T}_{C}$ drops with decreasing tolerance factor $t$ from a high near 350 K at $t=0.98$ to a ${T}_{C}^{*}\ensuremath{\approx}60$ K at $t&lt;~0.96$. The paramagnetic phase is a polaronic conductor; the ferromagnetic phase contains mobile electrons in extended states for larger tolerance factors $t&gt;{t}_{c}=0.96$, but remains polaronic for $t&lt;{t}_{c}$. The temperature dependence of the thermopower is used to explore the polaron-extended state transition for five nominal compositions ${({\mathrm{La}}_{1\ensuremath{-}x}{\mathrm{Nd}}_{x})}_{0.7}{\mathrm{Ca}}_{0.3}\mathrm{Mn}{\mathrm{O}}_{3}$ designed to have tolerance factors near the critical value ${t}_{c}$. Comparison of the temperature dependence of the thermopower, $\ensuremath{\alpha}(T)$, as a result of chemical pressure, i.e., $t&lt;1$, with that for hydrostatic pressure reveals an anomalously large compressibility of the Mn-O bonds, which is characteristic of a double-well potential at a crossover from an electronic state of lower mean kinetic energy to one of greater kinetic energy. It also reveals a trapping of mobile holes above ${T}_{C}$ that increases with decreasing ${T}_{C}$. In the orthomanganites, the crossover is from polaronic-$e$ to extended-${\ensuremath{\sigma}}^{*}$ electronic conduction at ${T}_{C}$, a crossover that is responsible for the "colossal" negative magnetoresistance observed in the orthomanganites.
Prognostic impact of the expression of NCR1 and NCR3 NK cell receptors and PD-L1 on advanced non-small cell lung cancer (2016)

The putative contribution of natural killer (NK) cells to immunosurveillance in non-small cell lung cancer (NSCLC) has been an ongoing conundrum. Here, we used a readily standardizable quantitative real time polymerase chain reaction (qRT-PCR) to measure the expression of NK cell receptors in total peripheral blood mononuclear cells (PBMC) from healthy volunteers (HV), patients with gastrointestinal stromal tumors (GIST), neuroblastoma (NB), melanoma or NSCLC. We quantified <i>NCR1</i> (which codes for NKp46) and <i>NCR3</i> (which codes for NKp30), as well as that of three <i>NCR3</i> splice variants (which give rise to immunostimulatory NKp30A and NKp30B, as well as to immunosuppressive NKp30C). NSCLC patients expressed lower levels of <i>NCR1</i> than did HV. Remarkably, <i>NCR3</i> was lower in NSCLC patients than in HV as well as in all other malignancies. Moreover, a discrete proportion of NSCLC patients exhibited a particular low ratio between NKp30B and NKp30C (ΔBC). In the overall cohort, low expression of <i>NCR3</i> correlated with poor overall and progression-free survival (PFS). When patients were stratified according to the level of PD-L1 expression by NSCLC cells, within the PD-L1<sup>high</sup> category (>5% positive tumors), the sole parameter that affected prognosis was the expression of <i>NCR1</i>. However, in patients bearing tumors with negative PD-L1 expression on tumor or tumor-infiltrating stromal cells, the ΔBC<sup>low</sup> patients exhibited a dismal prognosis. Altogether, these results strongly suggest that NK cells mediate immunosurveillance against NSCLC and that measuring NK cell receptor expression by blood cells can yield useful biomarkers for patient stratification.