gebhart/patrepeval huggingface dataset:
Characterisation of an antibody specific for coagulation factor VIII that enhances factor VIII activity (2009)

Many reports have identified factor (F)VIII inhibitory antibodies with epitopes located in all subunits of the FVIII molecule. Antibodies that promote FVIII activity do not appear to have been reported. We characterised, for the first time, a unique anti-FVIII monoclonal antibody, mAb216, that enhanced FVIII coagulant activity. The mAb216 shortened the activated partial thromboplastin time and specifically increased FVIII activity by approximately 1.5-fold dose-dependently. FXa generation and thrombin generation were similarly increased by approximately 1.4- and approximately 2.5-fold, respectively. An A2 epitope, not overlapping the common A2 epitope, was identified and the antibody was shown to enhance thrombin (and FXa)-catalysed activation of FVIII by modestly accelerating cleavage at Arg(372). The presence of mAb216 mediated an approximately 1.5-fold decrease in K(m) for the FVIII-thrombin interaction. Enhanced FVIII activity was evident to an equal degree, even the presence of anti-FVIII neutralising antibodies with epitopes in each subunit. In addition, mAb216 depressed the rates of heat-denatured loss of FVIII activity and FVIIIa decay by 2 to approximately 2.5-fold. We have developed an anti-A2, FVIII mAb216 that augmented procoagulant activity. This enhancing effect could be attributed to an increase in thrombin-induced activation of FVIII, mediated by cleavage at Arg(372) and a tighter interaction of thrombin with the A2 domain. The findings may cast new light on new principles for improving the treatment of haemophilia A patients.
Study protocol: Whole genome sequencing Implementation in standard Diagnostics for Every cancer patient (WIDE) (2020)

WIDE will yield the optimal conditions under which WGS can be implemented in a routine molecular diagnostics setting and establish the position of WGS compared to SOC diagnostics in routine clinical care.
Introduction (2017)

Abstract This chapter introduces the main themes of the book, which deals with states in the European Union. It examines how states have been reconfigured by five processes. First, the rise of globalization processes and international organizations mean states are increasingly influenced, constrained, measured, and rated by organizations, ideas, and norms over which they have no direct control. Second, the dilution of the classic Weberian state means that comparisons with the nominally ‘weak’ American state are pertinent to understanding new public–private relationships in policy. Third, the impact of policy crises—fiscal, security, and migration—have resulted in institutional reform and expansion of state policy instruments. Fourth, the changing scale—regional and urban—and rise of regulatory agencies is a major source of reconfiguration in European states. Fifth, the traditional monopoly on violence to protect citizens remains but is overstretched, and states have developed new ways to control and monitor populations.
An 80-Tile Sub-100-W TeraFLOPS Processor in 65-nm CMOS (2008)

This paper describes an integrated network-on-chip architecture containing 80 tiles arranged as an 8x10 2-D array of floating-point cores and packet-switched routers, both designed to operate at 4 GHz. Each tile has two pipelined single-precision floating-point multiply accumulators (FPMAC) which feature a single-cycle accumulation loop for high throughput. The on-chip 2-D mesh network provides a bisection bandwidth of 2 Terabits/s. The 15-FO4 design employs mesochronous clocking, fine-grained clock gating, dynamic sleep transistors, and body-bias techniques. In a 65-nm eight-metal CMOS process, the 275 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> custom design contains 100 M transistors. The fully functional first silicon achieves over 1.0 TFLOPS of performance on a range of benchmarks while dissipating 97 W at 4.27 GHz and 1.07 V supply.
Two-Timescale End-to-End Learning for Channel Acquisition and Hybrid Precoding (2021)

In this paper, we propose an end-to-end deep learning-based joint transceiver design algorithm for millimeter wave (mmWave) massive multiple-input multiple-output (MIMO) systems, which consists of deep neural network (DNN)-aided pilot training, channel feedback, and hybrid analog-digital (HAD) precoding. Specifically, we develop a DNN architecture that maps the received pilots into feedback bits at the receiver, and then further maps the feedback bits into the hybrid precoder at the transmitter. To reduce the signaling overhead and channel state information (CSI) mismatch caused by the transmission delay, a two-timescale DNN composed of a long-term DNN and a short-term DNN is developed. The analog precoders are designed by the long-term DNN based on the CSI statistics and updated once in a frame consisting of a number of time slots. In contrast, the digital precoders are optimized by the short-term DNN at each time slot based on the estimated low-dimensional equivalent CSI matrices. A two-timescale training method is also developed for the proposed DNN with a binary layer. We then analyze the generalization ability and signaling overhead for the proposed DNN based algorithm. Simulation results show that our proposed technique significantly outperforms conventional schemes in terms of bit-error rate performance with reduced signaling overhead and shorter pilot sequences.
INHIBITION OF TUMOR NECROSIS FACTOR-INDUCED LIVER TOXICITY AND LETHALITY BY THE ACUTE PHASE PROTEINS α-1-ACID GLYCOPROTEIN AND α-1-ANTITRYPSIN. (1997)

Libert, C.; Van Molle, W.; Hochepied, T.; Ameloot, P.; Everaerdt, B.; Gansemans, Y.; Grijalba, B.; Takahashi, N.; Truong, M.-J.; Fiers, W.; Brouckaert, P. Author Information
1H Dynamic Nuclear Polarization Based on an Endogenous Radical (2012)

We demonstrate a 15-fold enhancement of solid-state NMR signals via dynamic nuclear polarization (DNP) based on a stable, naturally occurring radical in a protein: the flavin mononucleotide (FMN) semiquinone of flavodoxin. The line width of flavodoxin's EPR signal suggests that the dominant DNP mechanism is the solid effect, consistent with the field-dependent DNP enhancement profile. The magnitude of the enhancement as well as the bulk-polarization build-up time constant (τ(B)) with which it develops are dependent on the isotopic composition of the protein. Deuteration of the protein to 85% increased the nuclear longitudinal relaxation time T(1n) and τ(B) by factors of five and seven, respectively. Slowed dissipation of polarization can explain the 2-fold higher maximal enhancement than that obtained in proteated protein, based on the endogenous semiquinone. In contrast, the long τ(B) of TOTAPOL-based DNP in nonglassy samples was not accompanied by a similarly important long T(1n), and in this case the enhancement was greatly reduced. The low concentrations of radicals occurring naturally in biological systems limit the magnitude of DNP enhancement that is attainable by this means. However, our enhancement factors of up to 15 can nonetheless make an important difference to the feasibility of applying solid-state NMR to biochemical systems. We speculate that DNP based on endogenous radicals may facilitate MAS NMR characterization of biochemical complexes and even organelles, and could also serve as a source of additional structural and physiological information.
ChemInform Abstract: Asymmetric Synthesis Using Tartrate Ester‐Modified Allylboronates. Part 2. Single and Double Asymmetric Reactions with Alkoxy‐Substituted Aldehydes. (1990)

Abstract The chiral allylboranate (I) with (R,R)‐configuration reacts with optically active cyclic alkoxy aldehydes such as (II), forming diastereoselectively allylic alcohols such as (III) and (IV).
Anti-inflammatory effects of non-statin low-density lipoprotein cholesterol-lowering drugs: an unused potential? (2020)

<i>Objectives</i>. Inflammatory responses are closely knit with low-density lipoprotein (LDL)-cholesterol in driving atherosclerosis. Even if LDL-cholesterol is causative to atherosclerotic diseases and LDL-cholesterol lowering reduces hard clinical endpoints, there is a residual risk for clinical events, possibly driven by inflammatory processes, in accordance with its role in autoimmune diseases. <i>Design</i>. As LDL-cholesterol treatment targets are reduced, the use of non-statin lipid-lowering drugs will probably increase. Atherosclerotic plaques evolve through lipid infiltration and modification in the intima, furthermore infiltration of cells including monocytes, macrophages, T-lymphocytes and neutrophils initiating inflammatory signaling. Here we briefly review inflammation in atherosclerosis and the effects of the non-statin lipid-lowering drugs on inflammation. The review is limited to the most common non-statin lipid lowering drugs, i.e. proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors, bile acid sequestrants (BAS) and cholesterol absorption inhibitors. <i>Results</i>. PCSK9 inhibition is mostly studied together with statins and is associated with a reduction of pro-inflammatory cytokines. Furthermore, PCSK9 inhibitors seem to have an effect on monocyte migration trough CCR2. They also have an interaction with sirtuins, possibly offering a therapeutic target. BAS have several interesting effects on inflammation, including reduction of pro-inflammatory cytokines and a reduction of the number of infiltrating macrophages, however there are relatively few reports considering that these drugs have been on the market for decades. Ezetimibe also has effects on inflammation including reduction of pro-inflammatory cytokines and adhesion molecules, however these effects are usually accomplished in tandem with statins. <i>Conclusion</i>. This topic adds an interesting piece to the puzzle of atherosclerosis, indicating that PCSK9 inhibition, BAS and ezetimibe all affect thromboinflammation.
Business Process Adaptations via Protocols (2006)

Business process management in service-oriented computing (SOC) environments poses special challenges. In particular, SOC environments are dynamic, thereby requiring frequent changes in business processes. Current business process modeling approaches handle such changes in an ad hoc manner, and lack a principled means of determining what needs to be changed and where. This paper addresses process adaptability through a novel application of business protocols, especially of protocol composition, introduced in our previous work. Through a real business scenario of auto-insurance claim processing, this paper demonstrates how a wide range of adaptations can be handled naturally and systematically via protocol composition. The illustrated adaptations have been evaluated via a prototype
Where is the beauty? (2012)

In this paper we describe a system that automatically extracts appealing scenes from a set of broadcasting videos. Unlike traditional computational aesthetic models that try to predict the hardly measurable degree of "beauty", we chose to build a system that retrieves "interesting" scenes. We create a training database of Flickr images annotated with their corresponding Flickr "interestingness" degree. We then extract existing and novel aesthetic/semantic features from the training set. Based on such features, we build a graded-relevance "interestingness" model and we rank the test shots according to their predicted "interestingness".
500-Gbps Parallel-WDM Optical Interconnect (2005)

This paper describes a 500-Gbps parallel wavelength-division multiplexed (PWDM) optical interconnect where 48 channels of 10.42-Gbps data are transmitted over a parallel 12-fiber ribbon with 4 wavelengths per fiber. The transmitter and receiver are each chip-scale packages with a footprint of 5 mm times 8 mm and a combined power consumption of 3 W. This work is motivated by the continually increasing bandwidth needs of short-distance computer processor interconnects, which are demanding optical solutions that maximize bandwidth per unit area, power consumption, and cost
Cloning of a Novel Transcription Factor-Like Gene Amplified in Human Glioma Including Astrocytoma Grade I (1997)

Gene amplification, which is generally considered to occur late in tumor development, is a common feature of high grade glioma. Up until now, there have been no reports on amplification in astrocytoma grade I. In this study, we report cloning and sequencing of a cDNA termed glioma-amplified sequence (GAS41) which was identified recently in a glioblastoma cell line by microdissection-mediated cDNA capture. This technique is tailored to isolate amplified genes from human tumors. An increased copy number of GAS41 was found in glioblastoma multiforme and astrocytoma III, and at a high frequency in astrocytoma grades I and II. Sequence comparison indicates a high homology between the GAS41 protein, the yeast and human AF-9 and the human ENL proteins. Both AF-9 and ENL belong to a new class of transcription factors, indicating that GAS41 might also represent a transcription factor. With GAS41 being the first gene found with increased copy number in low grade glioma, this study provides the first evidence that gene amplification can occur in early tumor development.
Assessing Response Time Effects of Forward Collision Warning HMIs with Central Tendency, Variance, and Dominance Tests (2014)

Reaction times (RTs) to driver warning system human-machine interface (HMI) designs are often used to assess their impact on driver detection performance. This paper introduces three different ways to statistically compare alternative HMIs in terms of RTs. The most commonly reported way is to compare central tendencies such as RT means or medians. A second approach, less commonly used, compares the variability in RT distributions associated with different HMIs as an assessment of the consistency of response effects elicited by an HMI across participants. The third method is to compare the RT distributions from alternative HMIs by means of ordinal dominance statistics. This assessment directly addresses the question: “Do people tend to respond faster with HMI A than HMI B (or vice versa)?” These alternative assessments are applied to RT data from a simulator study of several alternative forward collision warning (FCW) HMIs and the insights provided by each are discussed.
Urinary fumonisin B1 and estimated fumonisin intake in women from high‐ and low‐exposure communities in Guatemala (2013)

In Jutiapa, agroecological conditions favored FB production. UFB1 mirrored the estimated FB intake. UFB1 > 0.1 ng/mL resulted in a dose-dependent increase in the risk of exceeding FB intake of 2 μg/kg b.w./day compared to women with no detectable UFB1 . More than 50% exceeded 2 μg/kg b.w./day when UFB1 was >0.5 ng/mL. UFB2 and UFB3 were rarely detected confirming that FB1 is either absorbed better or preferentially excreted in urine.
Mechanisms of spatial current-density instabilities inp+−p−−n−p+−n++structures (1999)

Semiconductor ${p}^{+}\ensuremath{-}{p}^{\ensuremath{-}}\ensuremath{-}n\ensuremath{-}{p}^{+}\ensuremath{-}{n}^{++}$ structures with large junction and contact areas are treated as $1\ifmmode\times\else\texttimes\fi{}2$-dimensional active media, in which self-organized pattern formation can be expected. The local bistable behavior of the structures may emanate from two different mechanisms both governed by a nonlinear current feedback loop between the electrons and holes injected from the outer layers. By considering the device to be composed of an active subsystem with negative differential resistance, and a passive resistive layer with positive differential resistance, an analytical approach is suggested to understand and describe the corresponding physical mechanisms in a self-consistent way. Analytical solutions of the derived model equations allow a description of homogeneous stationary states and yield explicit expressions of the current-density vs voltage characteristics of the whole structure and its subsystems. A stability analysis of the homogeneous states with respect to two-dimensional transversal harmonic fluctuations is performed for the two cases under study. The resulting dispersion relations allow two different types of instability. While the first one is of Ridley's type, which is characteristic for any spatially extended electrical system with negative differential resistance, the second type can be considered as a solid-state analogue of Turing's instability known as a generic instability mechanism, which may lead, e.g., to the formation of periodic patterns.
Hard-Baked Photoresist as a Sacrificial Layer for Sub-180 °C Surface Micromachining Processes (2018)

This letter proposes a method for utilizing a positive photoresist, Shipley 1805, as a sacrificial layer for sub-180 °C fabrication process flows. In the proposed process, the sacrificial layer is etched at the end to release the structures using a relatively fast wet-etching technique employing resist remover and a critical point dryer (CPD). This technique allows high etching selectivity over a large number of materials, including silicon-based structural materials such as silicon-carbide, metals such as titanium and aluminum, and cured polymers. This selectivity, as well as the low processing thermal budget, introduces more flexibility in material selection for monolithic integration above complementary metal oxide semiconductor (CMOS) as well as flexible substrates.
Efficient runtime performance monitoring of FPGA-based applications (2009)

Embedded computing platforms have long incorporated non-traditional architectures (e.g., FPGAs, ASICs) to combat the diminishing returns of Moore's Law as applied to traditional processors. These specialized architectures can offer higher performance potential in a smaller space, higher power efficiency, and competitive costs. A price is paid, however, in development difficulty in determining functional correctness and understanding the performance of such a system. In this paper we focus on improving the task of performance debugging streaming applications deployed on FPGAs. We describe our runtime performance monitoring infrastructure, its capabilities and overheads on several different configurations of the monitor. We then employ the monitoring system to study the performance effects of provisioning resources for Mercury BLASTN, an implementation of the BLASTN sequence comparison application on an FPGA-accelerated system.
Binary nucleation in acid–water systems. II. Sulfuric acid–water and a comparison with methanesulfonic acid–water (1991)

This work presents a systematic investigation of binary nucleation rates for sulfuric acid and water and the effect of temperature on these rates at isothermal, subsaturated conditions. The results from nucleation rate measurements for the sulfuric acid (H2SO4) –water system are discussed and compared to those previously presented for methanesulfonic acid (MSA)–water [B. E. Wyslouzil, J. H. Seinfeld, R. C. Flagan, and K. Okuyama, J. Chem. Phys. (submitted)]. Experiments were conducted at relative humidities (Rh) ranging from 0.006&amp;lt;Rh&amp;lt;0.65, relative acidities (Ra) in the range of 0.04&amp;lt;Ra&amp;lt;0.46, and at three temperatures, T=20, 25, and 30 °C, in the continuous flow mixing-type apparatus described in Paper I. Particles were formed by binary nucleation and grew by condensation as the mixed stream flowed through an isothermal glass tube. Number concentrations observed at the exit of the nucleation and growth tube as a function of Rh and Ra are extremely sensitive to the binary nucleation rate, and from these data the nucleation rate was estimated as a function of saturation level and temperature. Particle size distributions were also measured using a specially constructed differential mobility analyzer. As anticipated, the H2SO4 particles formed by nucleation and growth are much smaller than those formed in the MSA–water experiments, but particle size distribution measurements confirm that most of the particles formed are being observed. The ratio of experimental to theoretical nucleation rates, Jexpt/Jtheor, was found to be a strong function of the predicted number of acid molecules in the critical nucleus for both the H2SO4 –water and MSA–water systems.
Design and development of next-generation bottom anti-reflective coatings for 45nm process with hyper NA lithography (2006)

Integrated circuit manufacturers are consistently seeking to minimize device feature dimensions in order to reduce chip size and increase integration level. Feature sizes on chips are achieved sub 65nm with the advanced 193nm microlithography process. R&D activities of 45nm process have been started so far, and 193nm lithography is used for this technology. The key parameters for this lithography process are NA of exposure tool, resolution capability of resist, and reflectivity control with bottom anti-reflective coating (BARC). In the point of etching process, single-layer resist process can't be applied because resist thickness is too thin for getting suitable aspect ratio. Therefore, it is necessary to design novel BARC system and develop hard mask materials having high etching selectivity. This system and these materials can be used for 45nm generation lithography. Nissan Chemical Industries, Ltd. and Brewer Science, Inc. have been designed and developed the advanced BARCs for the above propose. In order to satisfy our target, we have developed novel BARC and hard mask materials. We investigated the multi-layer resist process stacked 4 layers (resist / thin BARC / silicon-contained BARC (Si-ARC) / spin on carbon hard mask (SOC)) (4 layers process). 4 layers process showed the excellent lithographic performance and pattern transfer performance. In this paper, we will discuss the detail of our approach and materials for 4 layers process.
Scaling HDFS to More Than 1 Million Operations Per Second with HopsFS (2017)

HopsFS is an open-source, next generation distribution of the Apache Hadoop Distributed File System (HDFS) that replaces the main scalability bottleneck in HDFS, single node in-memory metadata service, with a no-shared state distributed system built on a NewSQL database. By removing the metadata bottleneck in Apache HDFS, HopsFS enables significantly larger cluster sizes, more than an order of magnitude higher throughput, and significantly lower client latencies for large clusters. In this paper, we detail the techniques and optimizations that enable HopsFS to surpass 1 million file system operations per second - at least 16 times higher throughput than HDFS. In particular, we discuss how we exploit recent high performance features from NewSQL databases, such as application defined partitioning, partition-pruned index scans, and distribution aware transactions. Together with more traditional techniques, such as batching and write-ahead caches, we show how many incremental optimizations have enabled a revolution in distributed hierarchical file system performance.