gebhart/patrepeval huggingface dataset:
Improved Battery State Estimation Under Parameter Uncertainty Caused by Aging Using Expansion Measurements (2020)

Accurate tracking of the internal electrochemical states of lithium-ion battery during cycling enables advanced battery management systems to operate the battery safely and maintain high performance while minimizing battery degradation. To this end, techniques based on voltage measurement have shown promise for estimating the lithium surface concentration of active material particles, which is an important state for avoiding aging mechanisms such as lithium plating. However, methods relying on voltage often lead to large estimation errors when the model parameters change during aging. In this paper, we utilize the in-situ measurement of the battery expansion to augment the voltage and develop an observer to estimate the lithium surface concentration distribution in each electrode particle. We demonstrate that the addition of the expansion signal enables us to correct the negative electrode concentration states in addition to the positive electrode. As a result, compared to a voltage only observer, the proposed observer can successfully recover the surface concentration when the electrodes' stoichiometric window changes, which is a common occurrence under aging by loss of lithium inventory. With a 5% shift in the electrodes' stoichiometric window, the results indicate a reduction in state estimation error for the negative electrode surface concentration. Under this simulated aged condition, the voltage based observer had 9.3% error as compared to the proposed voltage and expansion observer which had 0.1% error in negative electrode surface concentration.
Iron-Catalyzed Suzuki–Miyaura Cross-Coupling Reactions between Alkyl Halides and Unactivated Arylboronic Esters (2018)

An iron-catalyzed cross-coupling reaction between alkyl halides and arylboronic esters was developed that does not involve activation of the boronic ester with alkyllithium reagents nor requires magnesium additives. A combination of experimental and theoretical investigations revealed that lithium amide bases coupled with iron complexes containing deprotonated cyanobis(oxazoline) ligands were best to obtain high yields (up to 89%) in catalytic cross-coupling reactions. Mechanistic investigations implicate carbon-centered radical intermediates and highlight the critical importance of avoiding conditions that lead to iron aggregates. The new iron-catalyzed Suzuki-Miyaura reaction was applied toward the shortest reported synthesis of the pharmaceutical Cinacalcet.
Highly Efficient Photoinduced Electron Transfer with 2,4,6-Triphenylpyrylium Cation Incorporated inside Extra Large Pore Zeotype MCM-41 (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHighly Efficient Photoinduced Electron Transfer with 2,4,6-Triphenylpyrylium Cation Incorporated inside Extra Large Pore Zeotype MCM-41Avelino Corma, Vicente Fornes, Hermenegildo Garcia, Miguel A. Miranda, and Maria J. SabaterCite this: J. Am. Chem. Soc. 1994, 116, 21, 9767–9768Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/ja00100a059https://doi.org/10.1021/ja00100a059research-articleACS PublicationsRequest reuse permissionsArticle Views468Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Deep-learning-assisted diagnosis for knee magnetic resonance imaging: Development and retrospective validation of MRNet (2018)

Our deep learning model can rapidly generate accurate clinical pathology classifications of knee MRI exams from both internal and external datasets. Moreover, our results support the assertion that deep learning models can improve the performance of clinical experts during medical imaging interpretation. Further research is needed to validate the model prospectively and to determine its utility in the clinical setting.
Forward Scattering Series for 2-Parameter Acoustic Media: Analysis and Implications to the Inverse Scattering Task Specific Subseries (2008)

We study the 2-parameter acoustic Born series for an actual medium with constant velocity and a density distribution. Using a homogeneous background we define a perturbation, the difference between actual and reference medium (we use background and reference as synonyms), which exhibits an anisotropic behavior due to the density distribution. For an actual medium with a constant velocity, the refer- ence velocity can be selected so that the waves in the actual medium travel with the same speed as the waves in the background medium. Scattering theory decomposes the actual wave field into an infinite series where each term contains the perturbation and the propagators in the background medium. Hence, in this formalism, all prop- agations occur in the background medium and the actual medium is included only through the perturbations which scatter the propagating waves. The density-only per- turbation has an isotropic and an anisotropic component. The anisotropic component is dependent on the incident direction of the propagating waves and behaves as a pur- poseful perturbation in the sense that it annihilates the part of the Born series that acts to correct the time to build the actual wave field, an unnecessary activity when the ref- erence velocity is equal to the one in the actual medium. This means that the forward series is not attempting to correct for an issue that does not exist. We define the pur- poseful perturbation concept as the intrinsic knowledge of precisely what a given term is designed to accomplish. This is a remarkable behavior for a formalism that predicts the scatteredwave field with an infinite series. At eachorderof approximation the out- put of the series is consistent with the fact that the time is correct because the velocity is always constant. In the density-only perturbation, the forward series only seeks to predict the correct amplitudes. Finally, we extend the analysis to a wave propagating in a medium where both density and velocity change. By selecting a convenient set of parameters, we find a conceptual framework for the multiparameter Born series. This framework provides an insightful analysis that can be mapped and applied to the concepts and algorithms of the inverse scattering series.
Modeling and Simulating Human Activity (2000)

This paper describes a multi-agent approach for modeling and simulating the activities of humans and systems in organizations we refer to as work practice modeling. We describe a simulation experiment of the work practice of the Apollo 12 astronauts during the ALSEP offload activity.
Action of Phospholipase C on the Thyroid (1967)

Abstract Treatment of dog thyroid slices with an enzyme present in the growth medium of Clostridium perfringens makes them unresponsive to thyroid-stimulating hormone (TSH) as measured by the oxidation of glucose-1-14C to 14CO2. This enzyme appears to be phospholipase C since (a) both the anti-TSH effect and the phospholipase activity are inseparable over a 240-fold purification, (b) both activities are inhibited by 5 x 10-4 m ethylenediaminetetraacetate and destroyed by boiling, and (c) the addition of excess phospholipid protects the thyroid from the enzyme. Phospholipase C appears to abolish the responsiveness to TSH by producing a specific alteration in the thyroid cell membrane, since thyroids treated with enzyme oxidize glucose at a normal rate in the absence of TSH and respond normally to acetylcholine, a substance previously shown to increase glucose oxidation in the thyroid.
Abstract LB-008: KRAS engages AGO2 to enhance cellular transformation (2016)

Abstract Oncogenic mutations in RAS provide a compelling yet intractable therapeutic target. Approximately 30% of all cancers harbor activating mutations in the RAS family of small GTPase proteins, making it one of the most common oncogenic aberrations in humans. Normal RAS proteins (H, K or N-RAS) localize to the inner cell membrane and transduce extracellular growth signals by cycling between an “active” GTP-bound state and “inactive” GDP-bound state. Our understanding of RAS biology is primarily from RAS protein-effector interactions that activate a variety of effectors at the plasma membrane like RAF/PI3K/RalGDS. Yet, targeting mutant RAS proteins or its effectors / pathways remains a challenging endeavor for treating RAS driven cancers. For a comprehensive identification of RAS interactors, we recently performed co-immunoprecipitation (Co-IP) Mass Spectrometric analysis of RAS immunoprecipitates from multiple cancer cell lines with differing KRAS mutation status. In all the cell lines studies, we uncovered an interaction between RAS and the core component of the RNA silencing machinery, Argonaute 2 (AGO2). Endogenously expressed RAS and AGO2 co-sediment and co-localize in intracellular membrane bound endoplasmic reticulum. AGO2 binds the Switch II region in KRAS, irrespective of GDP/GTP bound to RAS. Both endogenous and overexpressed mutant forms of KRAS, attenuate AGO2 related gene silencing function. Using NIH3T3 AGO2-/- cells, we demonstrate that the RAS-AGO2 interaction is required for maximal mutant KRAS expression and cellular transformation. Overall, our studies suggest that through its interaction with AGO2, RAS function extends well beyond its canonical role in intracellular signaling. We will present detailed characterization of the RAS-AGO2 interaction and its functional aspects that we have discovered so far. Citation Format: Sunita Shankar, Sethuramasundaram Pitchiaya, Rohit Malik, Vishal Kothari, Yasuyuki Hosono, Anastasia K. Yocum, Harika Gundlapalli, Yasmine White, Ari Firestone, Xuhong Cao, Saravana M. Dhanasekaran, Jeanne Stuckey, Gideon Bollag, Kevin Shannon, Nils Walter, Chandan Kumar-Sinha, Arul M. Chinnaiyan. KRAS engages AGO2 to enhance cellular transformation. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr LB-008.
Retinoids regulate tight junctional resistance of cultured human cervical cells (1997)

The objective of the study was to determine the effect of retinoids on paracellular resistance across the cervical epithelium and the mechanisms involved. The experimental model was cultures of human CaSki cells on filters, which retain phenotypic characteristics of the endocervical epithelium. End points for paracellular resistance were measurements of transepithelial electrical resistance and fluxes of pyranine (a trisulfonic acid that traverses the epithelium via the intercellular space). Paracellular resistance was significantly increased in cells grown in retinoid-free medium; the effect could be blocked and reversed with all-trans-retinoic acid (tRA) and with agonists of RAR and RXR receptors but only partially with retinol. The effect of tRA was dose dependent and saturable, with a 50% effective concentration of 0.8 nM. The increases in paracellular resistance induced by vitamin A deficiency required longer incubation in retinoid-free medium than decreases in resistance induced by retinoic acid. tRA had only a minimal effect on paracellular resistance in cells maintained in regular medium. Retinoid-free medium increased and tRA decreased the relative cation mobility across CaSki cultures. Also the effects of tRA were nonadditive to those of cytochalasin D (which decreases tight junctional resistance) and additive to those of ionomycin (which decreases the resistance of the lateral intercellular space), suggesting that tRA modulates tight junctional resistance. It is concluded that vitamin A determines the degree of paracellular resistance across cervical cells by a mechanism that involves modulation of tight junctional resistance.
Immunological considerations of modern animal models of malignant primary brain tumors (2009)

Recent advances in animal models of glioma have facilitated a better understanding of biological mechanisms underlying gliomagenesis and glioma progression. The limitations of existing therapy, including surgery, chemotherapy, and radiotherapy, have prompted numerous investigators to search for new therapeutic approaches to improve quantity and quality of survival from these aggressive lesions. One of these approaches involves triggering a tumor specific immune response. However, a difficulty in this approach is the the scarcity of animal models of primary CNS neoplasms which faithfully recapitulate these tumors and their interaction with the host's immune system. In this article, we review the existing methods utilized to date for modeling gliomas in rodents, with a focus on the known as well as potential immunological aspects of these models. As this review demonstrates, many of these models have inherent immune system limitations, and the impact of these limitations on studies on the influence of pre-clinical therapeutics testing warrants further attention.
Erratum: Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo (2012)

In [1], the authors report that the central bar of the histogram in Figure 4C should reflect a value of 43.9 ± 12.1 rather than a value of 50 ± 12.1, as published in the original figure. This does not change the statistical analysis, the p value, or the conclusions drawn from the data. The corrected Figure 4 is shown in its entirety on the following page. Treatment with ActRIIA.muFc from week 1 after tumor cell innoculation prevents development of osteolytic disease in 5T2MM-bearing mice. µCT-reconstructed images of tibias (A) and femurs (B) of naive and 5T2MM-bearing mice treated with vehicle or with ActRIIA.muFc. Osteolytic lesions are arrowed. Histograms showing (C) osteolytic lesion number in naive mice and 5T2MM-bearing mice treated with vehicle or with ActRIIA.muFc and (D) trabecular bone volume (BV/TV, %), trabecular number (TB.N, /mm), and trabecular thickness (TB.TH, mm) in tibias and femurs of naive mice and 5T2MMbearing mice treated with vehicle or with ActRIIA.muFc. a = p <.05 compared with naive mice; b = p <.01 compared with naive mice; c = p <.05 compared with vehicle; d = p <.01 compared with vehicle; e = p <.001 compared with vehicle.
Microemulsion Polymerization of Styrene (1989)

The polymerization of styrene microemulsions prepared from water, sodium dodecyl sulfate, and 1-pentanol was carried out using water-soluble potassium persulfate or oil-soluble 2,2'-azobis(2-methyl butyronitrile) initiator at 70°C. The latexes were stable, bluish, and less translucent than the microemulsions. The polymerization rates measured by dilatometry increased to a maximum and then decreased (only two intervals). The maximum polymerization rate and number of particles varied with the 0.47 and 0.40 powers of potassium persulfate concentration, and the 0.39 and 0.38 powers of 2,2'-azobis(2-methyl butyronitrile) concentration, respectively. The small average latex particle sizes (20-30 nm) and high polymer molecular weights (1-2x106) showed that each latex particle comprised only 2-3 polystyrene molecules. The number of particles remained unchanged when the styrene was diluted with toluene at constant oil-phase volume. The mechanism proposed for both water-soluble and oil-soluble initiators comprised nucleation in the microemulsion droplets by radical entry from the aqueous phase, with the droplets which did not capture radicals serving as reservoirs to supply monomer to the polymer particles (homogeneous nucleation was not ruled out, however). This mechanism was compared with those proposed for conventional emulsion polymerization and miniemulsion polymerization.
Synthesis of 3‐(1,5‐diphenyl‐3‐pyrazolyl)aryl propanoates (1990)

Abstract New procedures for the synthesis of 3‐(1,5‐diphenyl‐3‐pyrazolyl)aryl propanoates and related 2‐(1,5‐diphenyl‐3‐pyrazolyl)aryl propanoates from a common 3‐hydroxymethylpyrazole intermediate are described. These new procedures include an improved method for carrying out pyridinium chlorochromate oxidations under ultrasonic conditions. These syntheses also utilize lithium triethylphosphonoacetate formed from n ‐butyllithium and triethylphosphonoacetate as a Wittig‐Horner reagent to improve olefination yields.
Minute Organic Memory Fabricated by Laser Scanning and Selective Metal‐Vapor Deposition of a Diarylethene–Cu Composite Film (2018)

Abstract One of the major challenges in the field of organic electronics is miniaturization and integration of electrical components. Such miniaturization, however, has been restricted strictly so far because of the difficulty in fabricating minute electrodes on organic layers and their patterning. The conventional metal electrode has been fabricated generally using vacuum evaporation with a shadow mask, and the resolution of the shadow mask limits the electrode size. In this study, a minute organic memory cell fabricated by laser scanning and maskless Mg‐vapor deposition is reported. This fabrication method is based on selective metal‐vapor deposition on photochromic diarylethene (DAE). To obtain electrical bistability for memory operation, a DAE–Cu composite film, prepared by Cu deposition onto the DAE surface at a high substrate temperature, is adopted. The optimum condition to achieve the compatibility of selective Mg‐vapor deposition and electrical bistability is revealed here. A larger ON–OFF ratio (OOR) in electrical bistability is obtained in a smaller cell and the 10 micron sized memory cell with a large OOR of 10 5 is demonstrated.
The distribution of target registration error in rigid-body point-based registration (2001)

Guidance systems designed for neurosurgery, hip surgery, spine surgery and for approaches to other anatomy that is relatively rigid can use rigid-body transformations to accomplish image registration. These systems often rely on point-based registration to determine the transformation and many such systems use attached fiducial markers to establish accurate fiducial points for the registration, the points being established by some fiducial localization process. Accuracy is important to these systems, as is knowledge of the level of that accuracy. An advantage of marker-based systems, particularly those in which the markers are bone-implanted, is that registration error depends only on the fiducial localization and is, thus, to a large extent independent of the particular object being registered. Thus, it should be possible to predict the clinical accuracy of marker-based systems on the basis of experimental measurements made with phantoms or previous patients. For most registration tasks, the most important error measure is target registration error (TRE), which is the distance after registration between corresponding points not used in calculating the registration transform. In this paper, we derive an approximation to the distribution of TRE; this is an extension of previous work that gave the expected squared value of TRE. We show the distribution of the squared magnitude of TRE and that of the component of TRE in an arbitrary direction. Using numerical simulations, we show that our theoretical results are a close match to the simulated ones.
Recent developments in liquid crystals for microwave applications (2017)

Recent developments in Liquid Crystal mixtures for tunable microwave applications have led to two material classes with increased performance. A high tunability material class provides a tunability above 30%, while a low loss material class has shown loss tangents down to 0.08.
Updatable Oblivious Key Management for Storage Systems (2019)

We introduce Oblivious Key Management Systems (KMS) as a much more secure alternative to traditional wrapping-based KMS that form the backbone of key management in large-scale data storage deployments. The new system, that builds on Oblivious Pseudorandom Functions (OPRF), hides keys and object identifiers from the KMS, offers unconditional security for key transport, provides key verifiability, reduces storage, and more. Further, we show how to provide all these features in a distributed threshold implementation that enhances protection against server compromise.
Workflow Data Exchange Semantics, Object Discovery &amp; Integration Architecture for Cross Media Production &amp; Distribution (2006)

There has been a clear lack of common data exchange semantics for inter-organisational workflow management systems where the research has mainly focused on technical issues rather than language constructs. This paper presents the neutral data exchanges semantics required for the workflow integration within the AXMEDIS framework and presents the mechanism for object discovery from the object repository where little or no knowledge about the object is available. The paper also presents workflow independent integration architecture with the AXMEDIS framework.
A fluorescent glucose assay using poly-L-lysine and calcium alginate microencapsulated TRITC-succinyl-concanavalin A and FITC-dextran (2002)

Glucose assays based on fluorescent quenching of fluorophores due to Fluorescent Resonance Energy Transfer (FRET) has previously been successfully developed in an aqueous medium. TRITC-succinyl-Con A and FITC-Dextran have been used to determine physiological glucose concentrations, based upon competitive binding between Con A, dextran, and glucose. In the absence of glucose, TRITC-succinyl-Con A binds with FITC-Dextran, and the FITC fluorescence is quenched. As glucose binds to TRITC-succinyl-Con A, FITC-Dextran is liberated. The resulting increase in FITC fluorescence is proportional to the concentration of glucose. The authors report on attempts to develop a polymer-based fluorescent sensor using FITC-Dextran and TRITC-Succinyl-Con A encapsulated in calcium alginate gel spheres surface modified with a sodium alginate and poly-L-lysine coating to stabilize the gel. In vitro experiments of the polymer spheres in a solution of dH/sub 2/O and glucose were conducted. The fluorescence change with increasing glucose concentration, ranging from 0 to 800 mg/mL, was linear from 0 to 600 mg/mL, with a reduced response at 800 mg/mL. This reduced response is likely due to the majority of the initially bound FITC-Dextran having been released.