gebhart/patrepeval huggingface dataset:
Long-wavelength vertical-cavity laser research at Gore (1999)

Vertical cavity surface emitting lasers (VCSELs) operating near 1310 or 1550 nm have been the subject of intensive research by multiple groups for several years. In the past year at Gore, we have demonstrated the first 1300 nm VCSELs which operate with useful power, high modulation rate, and low voltage over the commercial temperature range of 0 - 70 degree(s)C. These results have been achieved using a new structure in which an 850 nm VCSEL optical pump is integrated with the 1300 nm VCSEL. Electrical drive is applied to the 850 nm pump, and 1300 nm light is emitted from the integrated structure. This approach has resulted in over a milliwatt of single transverse mode power at room temperature, and several hundred microwatts of single transverse mode power at 70 degree(s)C. In addition, these devices demonstrate multi-gigabit modulation and excellent coupling efficiency to single-mode fiber.
High Pressure CO2 Removal with the FLUOR Solvent Physical Solvent Process (2006)

This paper reviews high CO2 partial pressure gas treating considerations and applications of the Fluor Solvent process to these gas streams. The discussion includes a recent plant survey of two Fluor Solvent plants - a natural gas treating plant operating at about 700 psig (48.3 barg) and a syngas treating plant operating at about 2,000 psig (138 barg). Performance data from these two plants are reviewed and several new Fluor Solvent Process configurations (patent pending) are also discussed. These new configurations are improvements over earlier designs in that they can process a wider range of gas streams with high CO2 content. One of the new configurations can be used for the production of liquid CO2 for enhanced oil recovery.

1.Introduction

As high quality natural gas resources are depleted, it is becoming necessary to produce less desirable natural gas reserves. In some cases, the acid gas concentration in these reserves is very high and the economics of producing pipeline quality gas are marginal. As the need to develop these marginal reserves increases, there is a demand for novel processes to economically remove acid gases. Physical solvents have an advantage over chemical solvents as their treating capacity increases with increasing acid gas partial pressure. The Fluor Solvent Process, based on the physical solvent propylene carbonate, has been proven in treating high CO2 content gases in both natural gas and syngas applications.
PubChain: A Decentralized Open-Access Publication Platform with Participants Incentivized by Blockchain Technology (2020)

We design and implement Publication Chain (PubChain), a decentralized open-access publication platform built on decentralized and distributed technologies of blockchain and IPFS peer-to-peer file sharing systems. The existing publication platforms have some severe drawbacks. First, instead of promoting widespread knowledge sharing, access to publications on the platforms owned by publishers is often on a fee basis. This drawback of pay wall prevents researchers from "standing on the shoulders of giants". Moreover, the peer review process on most all existing publication platforms (including both openaccess and publisher platforms) is prone to be ineffective, since there is no proper incentive to reviewers for performing high-qualified reviews. PubChain is an alternative platform to the existing publication venues aiming to address their drawbacks. No central third-party owns the contents (i.e., papers and reviews) of PubChain. Exploiting blockchain technology, we devise an elaborate incentive scheme on PubChain to incentivize key stakeholders (i.e., authors, readers and reviewers) to participate publication activities on PubChain in a substantive manner by earning credits and rewards through self-motivated interactions. We have performed simulations to investigate the robustness of our proposed incentive scheme against fraudulent publications and reviews. We also have implemented a prototype of PubChain to demonstrate its key concepts.
Analysis of longitudinal ends effects in a Linear Permanent Magnet Generator (2013)

This thesis presents research regarding a full scale linear ferrite permanent magnet generator, installed in a wave energy conversion system. The ferrite based magnetic circuit, supplementing the previous utilized Nd2Fe14B-magnet design, is designed with an electromagnetic numerical simulation tool, where the model is derived from Maxwell’s equations. The full scale design is, known to the author, the first developed linear ferrite based machine. The material change in the magnetic circuit required different mechanical solutions of the generator. The fundamental, primary theory and reasoning behind the new mechanical design is here presented, where sustainability, economy and production have been in focus and affected the final design. Two versions of the generator have been assembled and deployed at the projects experimental site on the Swedish west coast, and three more are under construction, planned to be installed during the autumn of 2013. Further, the thesis presents an electric conversion circuit based on the electric resonance phenomena. Full scale experimental results present a successfully achieved electric resonance between the linear wave energy generator and external circuit.Finally, research regarding a two pole permanent magnet motor for an electrical vehicle is presented. Detailed analytical and numerical calculations are utilized to investigate the losses in the machine over a wide frequency interval. The results indicate the possibility of an increased efficiency of electrical motors in electrical vehicle system and argue for elimination of the gearbox. The system total efficiency and mechanical stability can thereby be increased. The work concerning the wave energy converter is a part of a larger project, the Lysekil Wave Power Project, developed by a research group at Uppsala University, whereas the work concerning the electric motor so far has been carried out as an individual project. However, a future goal is to integrate the research on the electric motor for electric vehicles with ongoing research regarding a flywheel based electric driveline for an All Electric Propulsion System.
Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor–associated kinase 4 (IRAK4) (2019)

Interleukin-1 receptor-associated kinase 4 (IRAK4) is a key player in innate immune and inflammatory responses, performing a critical role in signal transduction downstream of Toll-like receptors and interleukin-1 (IL-1) receptors. Upon ligand binding and via its N-terminal death domain, IRAK4 is recruited to an oligomeric receptor that is proximal to the Myddosome signaling complex, inducing IRAK4 kinase domain dimerization, autophosphorylation, and activation. To date, all known IRAK4 structures are in the active conformation, precluding a good understanding of IRAK4's conformational dynamics. To address this issue, here we first solved three crystal structures of the IRAK4 kinase domain (at ≤2.6 Å resolution), in its unphosphorylated, inactive state bound to either the ATP analog AMP-PNP or to one of the two small-molecule inhibitors JH-I-25 and JH-I-17. The structures disclosed that although the structure in complex with AMP-PNP is in an "αC-out" inactive conformation, those in complex with type I inhibitors assume an active "Asp-Phe-Gly (DFG)-in" and "αC-in" conformation. The ability of unphosphorylated IRAK4 to take on variable conformations prompted us to screen for small-molecule inhibitors that bind preferentially to unphosphorylated IRAK4, leading to the identification of ponatinib and HG-12-6. Solving the structures of unphosphorylated IRAK4 in complex with these two inhibitors, we found that they both bind as type II inhibitors with IRAK4 in a "DFG-out" conformation. Collectively, these structures reveal conformational flexibility of unphosphorylated IRAK4 and provide unexpected insights into the potential use of small molecules to modulate IRAK4 activity in cancer, autoimmunity, and inflammation.
ChemInform Abstract: Electrospray Ionization Mass Spectrometry of Vitamin D Derivatives. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Small grains in M82 - A dusty halo surrounding the starburst (1989)

We have mapped the well-known starburst in M82 at 10.8, 19.2, and 30 microns. Scans along the galactic plane which are derived from these data reveal marked color variations with position. These color variations are correlated with the UV energy density in a manner explicable in terms of a heated mixture of dust grains extending to very small sizes. Many of the small grains may have been destroyed in the most intense regions of the starburst, but they have survived in a halo where the UV energy density is too low (&lt;~ 10 eV cm^-3^) to destroy them but still high enough to significantly heat them. We consider some implications of our results for interpreting IR continuum emission from starburst galaxies.
Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1 (2012)

Ovaries isolated from 2-year-old Laron dwarf mice exhibit a lower biological age compared with ovaries from normal WT littermates at the same age. At the same time, no morphological features of accelerated aging were found in 0.5-year-old bGHTg mice compared with ovaries from normal the same age-matched WT littermates.
Integrin mediated adhesion of mononuclear cells from patients with familial hypercholesterolemia (1999)

In contrast to studies by others, we demonstrated in the present study that the actual LFA-1 and VLA-4 mediated adhesion of T-lymphocytes and monocytes is not altered in patients with FH.
Vibrational relaxation of acetylene produced by the photolysis of vinyl bromide (1992)

Vibrational relaxation of the ν2 and 2ν2 CC stretch vibrational states in the ground electronic state of acetylene has been investigated using infrared kinetic spectroscopy. Excited vibrational states of acetylene are produced by 193 nm ArF excimer laser photolysis of vinyl bromide in a room-temperature helium buffer gas. Vibrational state populations are probed by direct absorption with the continuous single-frequency output of a color center laser operating in the 3 μm region. The vibrational transitions observed were the ν2+ν3−ν2 and the 2ν2+ν3−2ν2 combination bands. Rate constants for He vibrational relaxation are 1.5(3)×10−14 and 2.1(7)×10−14 cm3 molecule−1 s−1 for ν2 and 2ν2, respectively.
Identification of iron-activated and -repressed Fur-dependent genes by transcriptome analysis ofNeisseria meningitidisgroup B (2003)

Iron is limiting in the human host, and bacterial pathogens respond to this environment by activating genes required for bacterial virulence. Transcriptional regulation in response to iron in Gram-negative bacteria is largely mediated by the ferric uptake regulator protein Fur, which in the presence of iron binds to a specific sequence in the promoter regions of genes under its control and acts as a repressor. Here we describe DNA microarray, computational and in vitro studies to define the Fur regulon in the human pathogen Neisseria meningitidis group B (strain MC58). After iron addition to an iron-depleted bacterial culture, 153 genes were up-regulated and 80 were down-regulated. Only 50% of the iron-regulated genes were found to contain Fur-binding consensus sequences in their promoter regions. Forty-two promoter regions were amplified and 32 of these were shown to bind Fur by gel-shift analysis. Among these genes, many of which had never been described before to be Fur-regulated, 10 were up-regulated on iron addition, demonstrating that Fur can also act as a transcriptional activator. Sequence alignment of the Fur-binding regions revealed that the N. meningitidis Fur-box encompasses the highly conserved (NATWAT)3 motif. Cluster analysis was effective in predicting Fur-regulated genes even if computer prediction failed to identify Fur-box-like sequences in their promoter regions. Microarray-generated gene expression profiling appears to be a very effective approach to define new regulons and regulatory pathways in pathogenic bacteria.
Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4 (2017)

High-affinity and selective antagonists that are able to block the actions of both endogenous and synthetic agonists of G protein-coupled receptors are integral to analysis of receptor function and to support suggestions of therapeutic potential. Although there is great interest in the potential of free fatty acid receptor 4 (FFA4) as a novel therapeutic target for the treatment of type II diabetes, the broad distribution pattern of this receptor suggests it may play a range of roles beyond glucose homeostasis in different cells and tissues. To date, a single molecule, 4-methyl-<i>N</i>-9<i>H</i>-xanthen-9-yl-benzenesulfonamide (AH-7614), has been described as an FFA4 antagonist; however, its mechanism of antagonism remains unknown. We synthesized AH-7614 and a chemical derivative and demonstrated these to be negative allosteric modulators (NAMs) of FFA4. Although these NAMs did inhibit FFA4 signaling induced by a range of endogenous and synthetic agonists, clear agonist probe dependence in the nature of allosteric modulation was apparent. Although AH-7614 did not antagonize the second long-chain free fatty acid receptor, free fatty acid receptor 1, the simple chemical structure of AH-7614 containing features found in many anticancer drugs suggests that a novel close chemical analog of AH-7614 devoid of FFA4 activity, 4-methyl-<i>N</i>-(9<i>H</i>-xanthen-9-yl)benzamide (TUG-1387), will also provide a useful control compound for future studies assessing FFA4 function. Using TUG-1387 alongside AH-7614, we show that endogenous activation of FFA4 expressed by murine C3H10T1/2 mesenchymal stem cells is required for induced differentiation of these cells toward a more mature, adipocyte-like phenotype.
STAT5 Activity in Pancreatic β-Cells Influences the Severity of Diabetes in Animal Models of Type 1 and 2 Diabetes (2006)

Pancreatic beta-cell growth and survival and insulin production are stimulated by growth hormone and prolactin through activation of the transcription factor signal transducer and activator of transcription (STAT)5. To assess the role of STAT5 activity in beta-cells in vivo, we generated transgenic mice that expressed a dominant-negative mutant of STAT5a (DNSTAT5) or constitutive active mutant of STAT5b (CASTAT5) under control of the rat insulin 1 promoter (RIP). When subjected to a high-fat diet, RIP-DNSTAT5 mice showed higher body weight, increased plasma glucose levels, and impairment of glucose tolerance, whereas RIP-CASTAT5 mice were more glucose tolerant and less hyperleptinemic than wild-type mice. Although the pancreatic insulin content and relative beta-cell area were increased in high-fat diet-fed RIP-DNSTAT5 mice compared with wild-type or RIP-CASTAT5 mice, RIP-DNSTAT5 mice showed reduced beta-cell proliferation at 6 months of age. The inhibitory effect of high-fat diet or leptin on insulin secretion was diminished in isolated islets from RIP-DNSTAT5 mice compared with wild-type islets. Upon multiple low-dose streptozotocin treatment, RIP-DNSTAT5 mice exhibited higher plasma glucose levels, lower plasma insulin levels, and lower pancreatic insulin content than wild-type mice, whereas RIP-CASTAT5 mice maintained higher levels of plasma insulin. In conclusion, our results indicate that STAT5 activity in beta-cells influences the susceptibility to experimentally induced type 1 and type 2 diabetes.
A Review on Combustion Synthesis of Novel Materials: Recent Experimental and Modeling Results (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Toxicological assessment of Aralia mandshurica (Araliaceae) root extract after subchronic administration in rats. A biochemical and histological study (1994)

Abstract The toxic subchronic effect of an extract of Aralia mandshurica on rats of both sexes was studied over a period of 90 days (0.2, 1.7, 3.4 g/kg p.o.). The toxic effects of Aralia mandshurica on the following enzymes were evaluated: alanine amino transferase (ALT), aspartate amino transferase (AST), serum alkaline phosphatase (SAP), total proteins and serum urea. Blood samples were obtained by means of retroorbital puncture with a microcapillary tube on days 15, 30, 45, 75 and 90 of the administration of Aralia mandshurica. The body weight was registered every week, and at the end of the study a necropsy was performed and the liver, lungs, kidneys, heart, spleen, gonads and adrenal glands were weighed. Liver, gonads and kidneys were examined histologically. There was an increase in the levels of AST and SAP enzymes with a dose of 3.4 g/kg in both sexes on day 90 of administration, but no changes were observed in urea and serum protein. A significant decrease of the body weight was recorded in both sexes with a dose of 3.4 g/kg. Moreover, the animals treated with doses of 1.7 and 3.4 g/kg showed a diminution of faecal consistence. An increase of the liver weight was produced with all the doses of Aralia mandshurica , but neither macroscopic nor histological alterations were observed, as in the rest of the organs. Possible liver damage associated with this enzyme is discussed.
Multimaterial photosensitive fiber constructs enable large-area optical sensing and imaging (2009)

The process of optical imaging and the use of a glass lens have been hitherto inseparable since it is the lens that is responsible for mapping incoming rays to form an image. While performing this critical role, the lens, by virtue of its geometry and materials composition, presents constraints on the size, weight, angular field of view, and environmental stability of an optical imaging system as a whole. Here, a new approach to optical imaging is presented. Tough polymeric light-sensing fibers are suspended on a frame to form large-scale, low-density, two- and three-dimensional photonic meshgrids. While a single grid can indeed locate a point of illumination, it is the stacking of a multiplicity of such grids, afforded by their essential transparency, which allows for the detection of the direction of illumination with a wide angular field of view. A surface-spanning-arrangement of such fibers is used to extract an arbitrary optical intensity distribution in a plane using a tomographic algorithm. Lensless imaging is achieved by a volumetric fiber assembly that extracts both the phase and intensity distributions of an incoming electromagnetic field, enabling one to readily determine the object from which the field originally emanated. © 2009 SPIE.
Abstract 281: Identifying genetic variation and cellular heterogeneity with a comprehensive cancer analysis toolkit (2018)

Abstract Understanding disease development, progression and response to treatment remains elusive for most types of cancer. This is due both to the genetic complexity seen in tumors as well as differences in how the surrounding cells and immune system respond to the developing tumor. To fully understand all aspects of disease progression and response to treatment, a systems level approach is needed. We have developed a platform that allows for high resolution multi-omics analysis of the tumor and its microenvironment. This platform is built upon a microfluidic system that enables the production of hundreds of thousands to millions of partitioned barcoded reactions. On this platform we generate Linked-Reads that allow for the detailed resolution of complex structural variant events. To obtain more detailed information about tumor heterogeneity and clonal structure, we also perform single cell DNA analysis that allows for the detection of sub-megabase copy number variants at the single cell level.The platform also provides detailed resolution of the cells occupying the microenvironment surrounding the tumor. Using a combination of single cell gene expression and enriched V(D)J B and T cell repertoire analysis, we identify cells constituting a tumor, as well as the immune and nonimmune cells surrounding the tumor. We also provide single cell profiling of the paired antigen receptor chains for both B and T cells. As a demonstration, we have performed this analysis on three types of tumor samples: metastatic melanoma (MM), primary colorectal cancer (CRC) and primary clear cell renal carcinoma (CCRC). We are able to identify a clonal expansion in the CCRC sample and determine there is no expansion in the CRC sample. The combination of these approaches allows for unparalleled characterization of disease development, progression and response. Citation Format: Sarah Garcia, Rajiv Bharadwaj, Stéphane Boutet, Claudia Catalanotti, Valeria Giangerra, Josephine Lee, Jessica Terry, Stephen Williams, Grace X. Zheng, Tarjei Mikkelsen, Michael Schnall-Levin, Ben Hindson, Deanna M. Church. Identifying genetic variation and cellular heterogeneity with a comprehensive cancer analysis toolkit [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 281.
Location and molecular cloning of the structural gene for the deoxyguanosine triphosphate triphosphohydrolase of Escherichia coli (1989)

The structural gene for deoxyguanosine triphosphate triphosphohydrolase (dGTPase) (EC 3.1.5.1) and its regulator, optA, have been located on a lambda phage carrying a 17.5kb Escherichia coli DNA insert. The DNA fragment has been excised and ligated into pBR325 and also transferred to another lambda vector. From the results of transduction and transformation experiments, we find that the structural gene for dGTPase is very closely linked to optA and dapD, which locates it at approximately 3.6 minutes on the genetic map of E. coli K12. We propose the mnemonic dgt as the designation for the structural gene for this enzyme.
Chimie des processus biologiques (2014)

Enseignement Cours : Clusters métalliques et enzymes : le vivant inorganique Il est communément considéré que la matière vivante est organique. En réalité, on sait aujourd’hui qu’une très grande quantité de processus naturels dépendent de l’intervention d’un ou de plusieurs ions métalliques. Par exemple, près de 40 % des protéines ne fonctionnent que parce qu’elles fixent un ou plusieurs ions métalliques (sodium, magnésium, calcium, fer, zinc, cuivre, etc.) On les appelle des métalloprotéines...
Accuracy of Overlay Metrology with Nonp-enetrating and Negative-Charging Electron Beam of the Scanning Electron Microscope (2002)

The overlay metrology, which detects a difference in structures below insulator films, is realized by using the non-penetrating and negative-charging electron beam of the scanning electron microscope (SEM). Although high accuracy is obtained in a stable state of image contrast, it takes a long time to attain such state. It is shown experimentally that the speed of attaining the stable state depends on the linear charge density and that a high beam current is desirable for reducing measuring time.
A noise cancellation technique in active RF-CMOS mixers (2005)

Based on the physical understanding of noise mechanisms in active mixers, a noise cancellation technique to reduce the flicker-noise contribution of the switches in a Gilbert-type mixer is presented. A prototype double-balanced mixer in 0.13 /spl mu/m CMOS is fabricated as a proof of concept. The circuit achieves a flicker-noise corner almost an order-of-magnitude lower than that of a standard implementation without compromising the linearity, gain, or power consumption.