gebhart/patrepeval huggingface dataset:
A fast telemetric pressure and temperature sensor system for medical applications (2007)

A new implantable sensor system with RF data and energy link is presented. This system comprises a telemetry made of standard components and is connected via a micro cable to a well-known miniature pressure and temperature sensor−ASIC. Due to this separation of telemetry and sensor the total size at the measurement spot could be reduced to less than 4 Fr. (1.2 mm) including the whole encapsulation of the sensor. The complete system provides telemetric data transfer of pressure measurements, with at least 30 Hz and parallel temperature measurements of the arterial blood with up to 1 Hz. The system performance is demonstrated for in vitro as well as in vivo animal testings. The telemetry with electronics and the corresponding software in the implant as well as the reader station is built up modular. This gives the opportunity to equip the implant with additional different sensors.
Development of a novel fungicide, penthiopyrad<sup>#</sup> (2013)

Penthiopyrad is a novel fungicide belonging to the carboxamide group. This compound was discovered by Mitsui Chemicals Agro, Inc., and launched in Japan in 2010 under the trade name Affet® SC in the fruit and the vegetable market and in 2009 under the name Gaia® WDG in the turf market. Penthiopyrad has broad antifungal spectrum of not only Basidiomycetes but also Ascomycetes and Deuteromycetes, and as a result, the broad antifungal spectrum contributes to its excellent ability to control various kinds of diseases on important crops in one treatment.
Gene Expression Profiles of Primary Breast Carcinomas from Patients at High Risk for Local Recurrence after Breast-Conserving Therapy (2006)

No significant differences in gene expression between primary breast cancer tumors in patients with or without local recurrence after BCT were identified. Furthermore, analyses of primary tumors and local recurrences show a preservation of the overall gene expression pattern in the local recurrence, even after radiotherapy.
Novel Mouse Tauopathy Model for Repetitive Mild Traumatic Brain Injury: Evaluation of Long-Term Effects on Cognition and Biomarker Levels After Therapeutic Inhibition of Tau Phosphorylation (2019)

Traumatic brain injury (TBI) is a risk factor for a group of neurodegenerative diseases termed tauopathies, which includes Alzheimer's disease and chronic traumatic encephalopathy (CTE). Although TBI is stratified by impact severity as either mild (m), moderate or severe, mTBI is the most common and the most difficult to diagnose. Tauopathies are pathologically related by the accumulation of hyperphosphorylated tau (P-tau) and increased total tau (T-tau). Here we describe: (i) a novel human tau-expressing transgenic mouse model, TghTau/PS1, to study repetitive mild closed head injury (rmCHI), (ii) quantitative comparison of T-tau and P-tau from brain and plasma in TghTau/PS1 mice over a 12 month period following rmCHI (and sham), (iii) the usefulness of P-tau as an early- and late-stage blood-based biochemical biomarker for rmCHI, (iii) the influence of kinase-targeted therapeutic intervention on rmCHI-associated cognitive deficits using a combination of lithium chloride (LiCl) and R-roscovitine (ros), and (iv) correlation of behavioral and cognitive changes with concentrations of the brain and blood-based T-tau and P-tau. Compared to sham-treated mice, behavior changes and cognitive deficits of rmCHI-treated TghTau/PS1 mice correlated with increases in both cortex and plasma T-tau and P-tau levels over 12 months. In addition, T-tau, but more predominantly P-tau, levels were significantly reduced in the cortex and plasma by LiCl + ros approaching the biomarker levels in sham and drug-treated sham mice (the drugs had only modest effects on the T-tau and P-tau levels in sham mice) throughout the 12 month study period. Furthermore, although we also observed a reversal of the abnormal behavior and cognitive deficits in the drug-treated rmCHI mice (compared to the untreated rmCHI mice) throughout the time course, these drug-treated effects were most pronounced up until 10 and 12 months where the abnormal behavior and cognition deficits began to gradually increase. These studies describe: (a) a translational relevant animal model for TBI-linked tauopathies, and (b) utilization of T-tau and P-tau as rmCHI biomarkers in plasma to monitor novel therapeutic strategies and treatment regimens for these neurodegenerative diseases.
Controlling the Site Selectivity in Acylations of Amphiphilic Diols: Directing the Reaction toward the Apolar Domain in a Model Diol and the Midecamycin A1 Macrolide Antibiotic (2022)

Seeking to improve the site selectivity of acylation of amphiphilic diols, which is induced by imidazole-based nucleophilic catalysts and directs the reaction toward apolar sites, as we recently reported, we examined a new improved catalytic design and an alteration of the acylating agent. The new catalysts performed slightly better selectivity-wise in the model reaction, compared to the previous set, but notably could be prepared in a much more synthetically economic way. The change of the acylating agent from anhydride to acyl chloride, particularly in combination with the new catalysts, accelerated the reaction and increased the selectivity in favor of the apolar site. The new selectivity-inducing techniques were applied to midecamycin, a natural amphiphilic antibiotic possessing a secondary alcohol moiety in each of its two domains, polar as well as apolar. In the case of the anhydride, a basic dimethylamino group, decorating this substrate, overrides the catalyst's selectivity preference and forces selective acylation of the alcohol in the polar domain with a more than 91:1 ratio of the monoacylated products. To counteract the internal base influence, an acid additive was used or the acylating agent was changed to acyl chloride. The latter adjustment leads, in combination with our best catalyst, to the reversal of the ratio between the products to 1:11.
Glucose Concentration and Streptomycin Alter In Vitro Muscle Function and Metabolism (2014)

Cell culture conditions can vary between laboratories and have been optimised for 2D cell culture. In this study, engineered muscle was cultured in 5.5 mM low glucose (LG) or 25 mM high glucose (HG) and in the absence or presence (+S) of streptomycin and the effect on C2C12 tissue-engineered muscle function and metabolism was determined. Following 2 weeks differentiation, streptomycin (3-fold) and LG (0.5-fold) significantly decreased force generation. LG and/or streptomycin resulted in upward and leftward shifts in the force-frequency curve and slowed time-to-peak tension and half-relaxation time. Despite changes in contractile dynamics, no change in myosin isoform was detected. Instead, changes in troponin isoform, calcium sequestering proteins (CSQ and parvalbumin) and the calcium uptake protein SERCA predicted the changes in contractile dynamics. Culturing in LG and/or streptomycin resulted in increased fatigue resistance despite no change in the mitochondrial enzymes SDH, ATPsynthase and cytochrome C. However, LG resulted in increases in the β-oxidation enzymes LCAD and VLCAD and the fatty acid transporter CPT-1, indicative of a greater capacity for fat oxidation. In contrast, HG resulted in increased GLUT4 content and the glycolytic enzyme PFK, indicative of a more glycolytic phenotype. These data suggest that streptomycin has negative effects on force generation and that glucose can be used to shift engineered muscle phenotype via changes in calcium-handling and metabolic proteins.
Kirk, David, "A Journal and its Field: The Impact of the Journal of Curriculum Studies," Journal of Curriculum Studies, 26(November-December, 1994), 669-681. (1994)

Reviews the citation of articles from this journal by Social Science Citation Index and discusses the journal's impact.
Dual-color superresolution imaging using genetically expressed probes (2008)

We report dual-color superresolution imaging using endogenously expressed fluorescent proteins. An imaging resolution of 20-30 nm facilitates study of the ultrastructural relationship between proteins present in adhesion complexes at the surfaces of whole, fixed cells.
Über zweistufige Redoxsysteme, XVI1) Spektroskopie und Polarographie vinyloger Bibenzimidazole, Bibenzoxazole und Bibenzothiazole sowie ihrer Aza‐Derivate (1974)

Abstract Die vinylogen Verbindungen N1–3, O1–2, S1–3 sowie ihre Azaderivate N2 a 2 und S2 a 4 erweisen sich als zweistufige Redoxsysteme, deren Semichinonbildungskonstante K sem mit wachsender Kettenlänge stark fällt (ca. 10 5 → 10 1 ). Für die planaren vinylogen Systeme gilt log K Sem ˜ J Sem mm (Coulombsches Repulsionsintegral). Azasubstitution erhöht K Sem stark und verschiebt den gesamten Potentialbereich positiv. N3 a 4 , O3 a 4 und S3 a 4 zeigen keine reversible Oxidationswelle. Die schwach basischen Amidrazone AS und ASe bilden bei der elektrochemischen Oxidation Tetrazene (z. B. S2 a 4 ). Soweit möglich, werden die Elektronenspektren der Redoxsysteme mitgeteilt. Nur die Radikalkationen zeigen einen Vinylensprung von 100–140 nm.
Effective longitudinal shear moduli of random composites comprising radially-graded fibres (2009)

The homogenization problem for random composites comprising radially-graded fibres is dealt with, in the framework of antiplane shear deformations, by generalizing the Rayleigh multipole expansion method. The statistics of the effective moduli are obtained in simulation. The feasibility of reducing the shear stress at the fibre/matrix interface by properly grading the fibre stiffness along the radius is proved.
Lumbar Interbody Fusion Using Bone Morphogenetic Protein: Results and Fusion Assessment (2003)

Background: The rapid differentiation between intracerebral haemorrhage (ICH) and ischaemic stroke (IS) using biomarker testing would allow the prehospital, cause-specific management of stroke patients. Based on single measurements made during the acute phase of stroke, the value of serum glial fibrillary acidic protein (GFAP) was reported to be higher in ICH patients than in IS patients. The aim of the present study was to characterise the diagnostic window of serum GFAP for differentiating between ICH and IS. Methods: 63 stroke patients admitted within 6 h of symptom onset were prospectively included. ICH (n = 18) and IS (n = 45) were diagnosed using brain imaging. Blood sampling was scheduled for 1, 2, 3, 4, 6, 12, 24 and 48 h after stroke onset (if applicable), and serum GFAP was measured using an ELISA test. Results: For the first 24 h after stroke, median GFAP values in IS patients remained below the detection limit. Between 2 and 6 h of stroke onset, serum GFAP was significantly higher in ICH patients than in IS patients (p < 0.001 for all 4 time points). According to a receiver operating characteristic curve analysis, the overall diagnostic accuracy of GFAP in differentiating between ICH and IS was >0.80 within the 2- to 6-hour time window. Two hours after stroke onset, serum GFAP values were significantly correlated with ICH volume (r = 0.755, p = 0.007). Conclusions: The time window between 2 and 6 h after stroke onset is best for using GFAP to differentiate between ICH and IS. In the very early phase (i.e. <2 h), sensitivity for detecting ICH is low, thus hampering the application of GFAP as a near-patient test in the prehospital phase.
Vacuum Ultraviolet Spectrum of IBr (1972)

Abstract Rydberg transitions for the interhalogen IBr, are reported in the wavelength region 160-130 nm. Key Words: Vacuum Ultravioletiodine bromidespectrum
Liquid crystal Bragg filters (2011)

Bragg filters or gratings have the advantages of spectrally selective reflection and high diffraction efficiency, which make them useful for a variety of applications. Liquid crystal Bragg gratings possess an additional interesting and useful feature in that they are switchable or tunable. In switchable filters the reflection notch can be switched on and off, while in a tunable filter it can be scanned through a broad spectral range. We have explored these types of filters for several years and present a review of some of their more intriguing aspects. Two types of filter have been studied: holographic polymer-dispersed liquid crystals and cholesteric liquid crystals. We describe the Bragg diffraction of these two types of filter and explore their similarities and differences. Here we will focus on switching and tuning by external stimuli such as electric fields as well as thermal and mechanical mechanisms. We further describe the physics of these devices and point out some new features we have observed as well as open questions concerning their behavior.
Effect of organic solvent and anion type on cation binding constants with silica gel bound macrocycles and their use in designing selective concentrator columns (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of organic solvent and anion type on cation binding constants with silica gel bound macrocycles and their use in designing selective concentrator columnsMerlin L. Bruening, David M. Mitchell, Jerald S. Bradshaw, Reed M. Izatt, and Ronald L. BrueningCite this: Anal. Chem. 1991, 63, 1, 21–24Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/ac00001a004https://doi.org/10.1021/ac00001a004research-articleACS PublicationsRequest reuse permissionsArticle Views272Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Highly Dynamic Host Actin Reorganization around Developing Plasmodium Inside Hepatocytes (2012)

Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around developing Plasmodium berghei parasites inside human hepatoma cells. Actin reorganization is most prominent between 10 to 16 hours post infection and depends on the actin severing and capping protein, gelsolin. Live cell imaging studies also suggest that the hepatocyte cytoskeleton may contribute to parasite elimination during Plasmodium development in the liver.
A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)&#8211;Cell Interaction and the Resultant Bioeffects at the Single-cell Level (2017)

In this manuscript, we first describe the fabrication protocol of a microfluidic chip, with gold dots and fibronectin-coated regions on the same glass substrate, that precisely controls the generation of tandem bubbles and individual cells patterned nearby with well-defined locations and shapes. We then demonstrate the generation of tandem bubbles by using two pulsed lasers illuminating a pair of gold dots with a few-microsecond time delay. We visualize the bubble-bubble interaction and jet formation by high-speed imaging and characterize the resultant flow field using particle image velocimetry (PIV). Finally, we present some applications of this technique for single cell analysis, including cell membrane poration with macromolecule uptake, localized membrane deformation determined by the displacements of attached integrin-binding beads, and intracellular calcium response from ratiometric imaging. Our results show that a fast and directional jetting flow is produced by the tandem bubble interaction, which can impose a highly localized shear stress on the surface of a cell grown in close proximity. Furthermore, different bioeffects can be induced by altering the strength of the jetting flow by adjusting the standoff distance from the cell to the tandem bubbles.
Targeting DNA to a Previously Integrated Transgenic Locus Using Zinc Finger Nucleases (2012)

Targeting exogenously supplied DNA to a predetermined location within a plant genome provides a powerful tool for basic studies of plant gene function and opens up some intriguing possibilities for crop improvement. The induction of double-strand DNA breaks at specific genomic loci via the use of designed zinc finger nucleases (ZFNs) allows for targeted transgene integration. Preintegrating a reporter construct containing a nonfunctional herbicide resistance gene flanked by ZFN binding sites results in a locus capable of being targeted. Retransformation with a corresponding ZFN-expressing cassette and a donor DNA with sequences homologous to the integrated construct and capable of functionalizing the herbicide resistance gene following site-specific integration results in targeted DNA addition. Targeted DNA integration can be confirmed in herbicide-resistant plant cells using PCR analysis.
Neural Contextual Bandits Based Dynamic Sensor Selection for Low-Power Body-Area Networks (2022)

Providing health monitoring devices with machine intelligence is important for enabling automatic mobile healthcare applications. However, this brings additional challenges due to the resource scarcity of these devices. This work introduces a neural contextual bandits based dynamic sensor selection methodology for high-performance and resource-efficient body-area networks to realize next generation mobile health monitoring devices. The methodology utilizes contextual bandits to select the most informative sensor combinations during runtime and ignore redundant data for decreasing transmission and computing power in a body area network (BAN). The proposed method has been validated using one of the most common health monitoring applications: cardiac activity monitoring. Solutions from our proposed method are compared against those from related works in terms of classification performance and energy while considering the communication energy consumption. Our final solutions could reach $78.8\%$ AU-PRC on the PTB-XL ECG dataset for cardiac abnormality detection while decreasing the overall energy consumption and computational energy by $3.7 \times$ and $4.3 \times$, respectively.
Adsorption of molecular oxygen by polymer covalently bonded co(II) porhyrin complex in toluene (1978)

Abstract Reaction betwenn molecular oxygen and polystyrene covalently bonded Co(II) protoporphyrin IX complex, which was prepaired by the incorporation of a cobaltous ion into the metal‐free porphyrin polymer, was studied in the presence of N ‐ethylimidazole by measuring visible absorption and electron spin resonance spectra. It was found that the complex forms a monomeric oxygen adduct reversibly at low temperature dependent on oxygen pressure. In the presence of molecular oxygen, a new electron spin resonance signal due to the oxygen complex at g iso =2.02 shows no superhyperfine splitting structure in fluid toluene solution even at −80 °C, but it was observed in frozen toulene glass solution at −120°C, The oxygen adducts of the complexes between C0(II) protoporphyrin IX dimethyl ester and N ‐ethylimidazole and copoly(styrene‐ N ‐vinylimidazole) showed eight resolved superhyperfine splitting at −40 and −60°C, respectively. The polymer covalently bonded Co(II) complex with N ‐ethylimidazole was oxidized at room temperature under oxygen atmosphere. It was suggested that a Co(II) porphyrin–oxygen adduct with an axial ligand may be oxidised monomolecularly at high temperature.
Unsaturated NHC Complexes Immobilized by the Backbone: Synthesis and Application (2013)

Abstract The synthesis and an exemplary catalytic application of a SBA‐15‐supported rhodium– N ‐heterocyclic carbene (NHC) complex is reported. In contrast to the conventional method of immobilization of unsaturated NHC complexes, the rhodium–NHC compound described here is connected to the SBA‐15 surface by a linker originating from the backbone of the unsaturated NHC ligand. The unique characteristics of the new immobilization mode enable the supported NHC complexes to maintain two unchanged “wing‐tip” ligands. This method of immobilization of unsaturated NHC complexes provides a new way to maintain the original configuration of homogeneous NHC complexes in the heterogenized catalytic system. The immobilized rhodium–NHC catalyst is used in a hydrogenation reaction with styrene as substrate.
<title>Reverse saturable absorption in polymethine dyes</title> (1997)

Thenonlinear absorption of a series of polymethine dyes (PD's) have been investigated, and some of them are identified as potential candidates for optical limiting applications. We have demonstrated that very low optical limiting thresholds can be obtained by using polymethine dyes with a large ratio of the absorption cross section ofthe excited to the ground-state: a ratio as large as 200 has been measured in one of the PD's. This value is significantly higher than any previously reported value, while, at the same time, maintaining a large ground-state cross section. It has been shown that nonlinear absorption of PD's in polyurethane acrylate (PUA) polymer is as large as in ethanol solution. In addition, photostability of the PD's and initial measurements ofoptical limiting in these samples are reported.
Survey of CT radiation dose levels during PET/CT from ACR CT Dose Index Registry (2015)

1696 Objectives Several societies are proposing diagnostic reference levels to provide common benchmarks for typical radiation dose levels. Despite awareness that CT acquisitions can be performed for different reasons during PET/CT exams, there is little to no data on the normative practice in the US for these acquisitions. In this work, the American College of Radiation (ACR) and the SNMMI Dose Optimization task force partnered to summarize CT dosing strategies for PET/CT. Methods CT exams, with keywords associated with whole-body PET/CT exams, were extracted from the ACR CT Dose Index Registry (DIR). The CT Dose Index (CTDIvol), dose length product (DLP), and number of acquisitions were analyzed for all exams. Results In total, 24,785 CT acquisitions from whole body-PET/CT studies from 35 facilities were evaluated from July 2011 to December 2014. For the CT for these exams, the average total CTDIvol was 11.7 mGy (IQR: 4.2-14.5 mGy) and DLP was 672 (IQR: 376-861) mGy*cm. These dose levels would lead to an effective dose of roughly 11.1 mSv (IQR: 6.2-14.2 mSv). Results suggest that most sites perform one CT acquisition per PET/CT exam, while 25% of sites perform 2 or more CT acquisitions per PET/CT. Conclusions The CT acquisition during whole-body PET/CT can be performed for attenuation correction only (0.5-2 mSv), localization (2-6 mSv), or diagnostic purposes (7-20 mSv). These results demonstrate that most of the sites participating in the ACR DIR are using the CT for diagnostic purposes. While this is the largest survey of CT practice for PET/CT in the US, the results likely do not capture the diversity of PET/CT practice in the US. In particular, the results are likely more reflective of CT-focused practices, such as those that engage in the ACR DIR.