gebhart/patrepeval huggingface dataset:
Application-specific, dynamic reservation of 5G compute and network resources by using reinforcement learning (2022)

5G services and applications explicitly reserve compute and network resources in today's complex and dynamic infrastructure of multi-tiered computing and cellular networking to ensure application-specific service quality metrics, and the infrastructure providers charge the 5G services for the resources reserved. A static, one-time reservation of resources at service deployment typically results in extended periods of under-utilization of reserved resources during the lifetime of the service operation. This is due to a plethora of reasons like changes in content from the IoT sensors (for example, change in number of people in the field of view of a camera) or a change in the environmental conditions around the IoT sensors (for example, time of the day, rain or fog can affect data acquisition by sensors). Under-utilization of a specific resource like compute can also be due to temporary inadequate availability of another resource like the network bandwidth in a dynamic 5G infrastructure. We propose a novel Reinforcement Learning-based online method to dynamically adjust an application's compute and network resource reservations to minimize under-utilization of requested resources, while ensuring acceptable service quality metrics. We observe that a complex application-specific coupling exists between the compute and network usage of an application. Our proposed method learns this coupling during the operation of the service, and dynamically modulates the compute and network resource requests to mimimize under-utilization of reserved resources. Through experimental evaluation using real-world video analytics application, we show that our technique is able to capture complex compute-network coupling relationship in an online manner i.e. while the application is running, and dynamically adapts and saves upto 65% compute and 93% network resources on average (over multiple runs), without significantly impacting application accuracy.
The translational mobility of substances within the cytoplasmic matrix. (1984)

The translational mobility of fluorescent-labeled molecules injected into the cytoplasm of living cells can be measured by the fluorescence recovery after photobleaching (FRAP) technique. In the fibroblast cytoplasm, the diffusion coefficients, D, of test macromolecules ranging in molecular weight from 12,000 to 440,000 are about 10(-8) cm2/sec and exhibit almost no dependence on molecular weight. FRAP experiments also showed that macromolecular diffusion within Sepharose beads having an effective pore size smaller than the "microtrabecular lattice" is only slightly retarded compared to buffer values--in contrast to the marked retardation measured in the cytoplasm. This leads to the conclusion that diffusion in the cytomatrix is dominated not by steric effects but rather by binding of the diffusing species to elements of the cytomatrix. These diffusion rates were difficult to modulate; cytochalasin, colchicine (except at 5 degrees C), and taxol treatments had little effect. The diffusion rates were not dependent on cellular energy metabolism. However, hypotonic treatment increased the D for bovine serum albumin by nearly 2-fold, whereas hypertonic treatment halved D. Withdrawing the free water from the cell by using 44% polyethylene glycol treatment stopped the translational mobility of the test molecules. A survey of the recent literature is presented, which shows that major differences in the cytomatrix of different cell types exist with respect to the translational diffusion of injected probes. Finally, the spectrum of cytoplasmic translational mobilities ranging from small molecules to organelles is discussed.
Psychological distress and risk of pre‐diabetes and Type 2 diabetes in a prospective study of Swedish middle‐aged men and women (2008)

The results indicate that psychological distress, including symptoms of anxiety, apathy, depression, fatigue and insomnia, increases the risk of pre-diabetes and Type 2 diabetes in Swedish middle-aged men. Increased risks were not present in women, except for pre-diabetes in the middle index group.
Evaluating the efficacy of continuous, low irradiance photodynamic therapy in vivo: artificial light versus natural sunlight (Conference Presentation) (2018)

Introduction: Topical photodynamic therapy (PDT) is a popular treatment for many non-melanoma skin cancers including actinic keratosis, Bowen’s disease, and some basal cell carcinomas. A chief complaint among patients is the pain that sometimes accompanies the procedure. This has led to a surge of interest in continuous, low-fluence rate PDT which is thought to be less painful. There is myriad evidence in the literature to suggest that natural sunlight can be an effective photo-activator of PpIX, the cytotoxic intermediate. However, there is some concern among the dermatological community regarding the degree to which this method of light delivery may be controlled. It is in this vein that we seek to compare the efficacy of natural sunlight with artificial light. Purpose: The present study compares three low-fluence rate light sources in normal mouse skin, combined with ALA-PDT. The light sources of interest are natural sunlight, a 415 nm LED bulb, and a broad spectrum, white light, horticultural bulb. Methods: A PpIX weighted fluence of 20 J/cm^2 was given to each light group, delivered over ~ 2 hours. Acute indicators of PDT efficacy were assayed via PpIX dosimetry, interrogation of Stat3 crosslinking, and analysis of epidermal keratinocytes for morphological changes.
ChemInform Abstract: Trichodion, a New Bioactive Pyrone from a Trichosporiella Species. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
LIVING WITH THE HIV/AIDS CARRIER: OPINION OF CARNIVAL PARTICIPANTES (2013)

Objective: to identify people's opinion about the coexistence with HIV bearer. Method: this was a descriptive research with a quantitative approach, held in Rio de Janeiro in 2011. The sample was randomly composed by 630 participants of the samba school parades, by applying a structured interview script. The data were tabulated, organized and analyzed using descriptive statistics; being approved by the CEP of the University Veiga de Almeida number 270/11. Results: the majority of respondents would not have protected sex with a person with HIV/AIDS; they consider that this person should always work and would not worry that their child studies with a virus carrier. Conclusion: The results indicate that living with a person with HIV at work or school, have higher acceptance than the maintenance of sexual relationship, and is necessary to highlight the importance of demystifying the subject.
Micro Artificial Muscle Actuator using Jet Flow of Electro-conjugate Fluid (2005)

Soft mechanics inspired from natural systems is one of keywords in the robotic field in last decate. Accordingly, artificial muscles were widely investigated due to their potentials in soft machines or soft robots. There developed many types of artificial muscles including pneumatic ones, ion-exchange polymer composite ones, polymer gels, shape memory alloys, and so on, however, they are not used as a practical actuator. In this study, the authors propose a new type of micro artificial muscle actuator (<1 cm3) utilizing the electro-conjugate fluid (ECF) which generates powerful jet flow (ECF jet) with high voltage supply (-kV). The actuator is mainly composed of a fiber-reinforced silicone rubber tube and a micro pressure source using the ECF. The inner pressure of the silicone rubber tube is increased by the ECF jet generated at the pressure source. The silicone rubber tube contracts along the actuator axis with the increasing pressure. The driving characteristics of the micro artificial muscle actuator were experimentally investigated. The experimental results confirm the effectiveness of the proposed actuator.
Negative modulation of α5GABAAreceptors in rats may partially prevent memory impairment induced by MK-801, but not amphetamine- or MK-801-elicited hyperlocomotion (2015)

Reportedly, negative modulation of α5 GABAA receptors may improve cognition in normal and pharmacologically-impaired animals, and such modulation has been proposed as an avenue for treatment of cognitive symptoms in schizophrenia. This study assessed the actions of PWZ-029, administered at doses (2, 5, and 10 mg/kg) at which it reached micromolar concentrations in brain tissue with estimated free concentrations adequate for selective modulation of α5 GABAA receptors, in three cognitive tasks in male Wistar rats acutely treated with the noncompetitive N-methyl-d-aspartate receptor antagonist, MK-801 (0.1 mg/kg), as well in tests of locomotor activity potentiated by MK-801 (0.2 mg/kg) or amphetamine (0.5 mg/kg). In a hormetic-like manner, only 5 mg/kg PWZ-029 reversed MK-801-induced deficits in novel object recognition test (visual recognition memory), whereas in the Morris water maze, the 2 mg/kg dose of PWZ-029 exerted partial beneficial effects on spatial learning impairment. PWZ-029 did not affect recognition memory deﬁcits in social novelty discrimination procedure. Motor hyperactivity induced with MK-801 or amphetamine was not preventable by PWZ-029. Our results show that certain MK-801-induced memory deficits can be ameliorated by negative modulation of α5 GABAA receptors, and point to the need for further elucidation of their translational relevance to cognitive deterioration in schizophrenia.
Graphenes Converted from Polymers (2011)

Because the direct formation of large, patterned graphene layers on active electronic devices without any physical transfer process is an ultimate important research goal for practical applications, we first developed a cost-effective, scalable, and sustainable process to form graphene films from solution-processed common polymers directly on a SiO2/Si substrate. We obtained few-layer graphene by heating the thin polymer films covered with a metal capping layer in a high-temperature furnace under low vacuum in an Ar/H2 atmosphere. We find that the metal capping layer appears to have two functions: prevention of vaporization of dissociated molecules and catalysis of graphene formation. We suggest that polymer-derived graphene growth directly on inert substrates in active electronic devices will have great advantages because of its simple, inexpensive, and safer process.
In Vivo Prevention of Bladder Urotoxicity (2011)

Urotoxicity is a troublesome complication associated with cyclophosphamide (CP) and L-buthionine-SR-sulfoximine (BSO) treatment in chemotherapy. With this concern in mind, the present study investigated the potential effects of a hydroxytyrosol extract from olive mill waste (OMW) on urotoxicity induced by acute CP and BSO doses using a Swiss albino mouse model. Toxicity modulation was evaluated by measuring lipid peroxidation (LPO) and antioxidants in urinary bladder. The findings revealed that the hydroxytyrosol extract exerted a protective effect not only on LPO but also on enzymatic antioxidants. When compared to the controls, the CP-treated animals underwent significant decreases in the glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GP), and catalase (CAT) activities. The level of glutathione (GSH) was also reduced with increased doses of LPO in the CP-treated animals. L-Buthionine-SR-sulfoximine treatment exerted an additive toxic effect on the CP-treated animals. Interestingly, pretreatment with the hydroxytyrosol extract restored the activities of all enzymes back to normal levels and exhibited an overall protective effect on the CP- and BSO-induced toxicities in urinary bladder. The restoration of GSH through the treatment with the hydroxytyrosol extract can play an important role in reversing CP-induced apoptosis and free radical-mediated LPO.
Neuroinflammation Extends Brain Tissue at Risk to Vital Peri-Infarct Tissue: A Double Tracer [11C]PK11195- and [18F]FDG-PET Study (2009)

Focal cerebral ischemia elicits strong inflammatory responses involving activation of resident microglia and recruitment of monocytes/macrophages. These cells express peripheral benzodiazepine receptors (PBRs) and can be visualized by positron emission tomography (PET) using [(11)C]PK11195 that selectively binds to PBRs. Earlier research suggests that transient ischemia in rats induces increased [(11)C]PK11195 binding within the infarct core. In this study, we investigated the expression of PBRs during permanent ischemia in rats. Permanent cerebral ischemia was induced by injection of macrospheres into the middle cerebral artery. Multimodal imaging 7 days after ischemia comprised (1) magnetic resonance imaging that assessed the extent of infarcts; (2) [(18)F]-2-fluoro-2-deoxy-D-glucose ([(18)F]FDG)-PET characterizing cerebral glucose transport and metabolism; and (3) [(11)C]PK11195-PET detecting neuroinflammation. Immunohistochemistry verified ischemic damage and neuroinflammatory processes. Contrasting with earlier data for transient ischemia, no [(11)C]PK11195 binding was found in the infarct core. Rather, permanent ischemia caused increased [(11)C]PK11195 binding in the normoperfused peri-infarct zone (mean standard uptake value (SUV): 1.93+/-0.49), colocalizing with a 60% increase in the [(18)F]FDG metabolic rate constant with accumulated activated microglia and macrophages. These results suggest that after permanent focal ischemia, neuroinflammation occurring in the normoperfused peri-infarct zone goes along with increased energy demand, therefore extending the tissue at risk to areas adjacent to the infarct.
The COL11A1 gene is associated with human stature in two population cohorts (2007)

Most human traits and common diseases have a complex genetic makeup involving more than one gene. The work presented in this thesis investigates standing body height and the common disease type 2 diabetes mellitus (T2DM). In study I we analyzed two single nucleotide polymorphisms (SNPs) in the TCF7L2 gene that had been shown to be associated with T2DM. Analysis was performed in the ULSAM population cohort of ~1500 males. We were able to replicate the association to type 2 diabetes and in addition to that we made a novel find, showing association between the risk alleles and increased proinsulin levels. In study II we analyzed four genes identified to be associated with T2DM in a genome-wide association study. We analyzed SNPs in these genes in the ULSAM population cohort and found an association between SNPs in the HHEX gene and insulin responses and insulin levels. The aim of studies III-V was to identify genes affecting normal variation in standing body height. Using a candidate gene approach in study III, 17 genes were screened in the ULSAM population cohort using SNPs. A suggestive association of the ESR1 gene with height was found and confirmed as significant in males from the PIVUS population cohort. In study IV, as a part of the GenomEUtwin project, we performed genetic fine mapping of a linked locus for body height on the X-chromosome. By analyzing 1377 SNPs in 780 Finnish twins, we mapped a region spanning 65kb of this locus with linkage to body height in males. This region contains the GPC3 and PHF6 genes that have known connections to syndromes were standing body height is affected. In study V significant linkage and association to standing body height in males was found for the COL1A11 gene, using population cohorts from Finland and Iceland.
Mechanical properties of micro- and nanocrystalline diamond foils (2015)

Diamond coating of suitable template materials and subsequent delamination allows for the manufacturing of free-standing diamond foil. The evolution of the microstructure can be influenced by secondary nucleation via control of process conditions in the hot-filament chemical vapour deposition process. Bending tests show extraordinarily high strength (more than 8 GPa), especially for diamond foils with nanocrystalline structure. A detailed fractographic analysis is conducted in order to correlate measured strength values with crack-initiating defects. The size of the failure causing flaw can vary from tens of micrometres to tens of nanometres, depending on the diamond foil microstructure as well as the loading conditions.
Simple interferometric fringe stabilization by charge-coupled-device-based feedback control (2006)

A method for producing stabilized interference patterns for ultraviolet interference lithography using a CCD camera as the detector element is described. Intensity data obtained from the CCD element are filtered in software to minimize speckle and detector noise effects as well as to determine the relative phase of the interfering beams. A control signal is then issued to correct the fringe drift. The system allows rapid reconfiguration of the lithography setup with minimum realignment of optical components.
A binder-free process for making all-plastic substrate flexible dye-sensitized solar cells having a gel electrolyte (2012)

Binder-free electrophoretic deposition (EPD) and mechanical compression were employed to fabricate TiO2 photoanodes for use in all-plastic substrate flexible dye-sensitized solar cells having a gel electrolyte. The photoanodes were composed of commercial 20 nm TiO2 powders with and without the addition of 160 nm TiO2 powders. The EPD was performed under different DC powers and deposition times to obtain photoanodes having different thicknesses. Depending on the thickness, various electron diffusion times, ranging from 8.08 to 12.40 ms, and electron lifetimes, ranging from 16.79 to 32.05 ms, were obtained for the photoanodes consisting of only commercial 20 nm TiO2. The electron diffusion time was reduced and the electron lifetime remained the same as a result of the addition of another commercial 160 nm TiO2 powder. The added 160 nm TiO2 powders enhanced the light absorptance by serving as light scattering centers. All-plastic flexible dye-sensitized solar cells were made and evaluated. Compared to the 20 nm TiO2 only cells, the cells containing mixed powders exhibit enhanced efficiencies and the enhancement can be as much as 22%.
Continuous Flow, Circulating Microwave System and Its Application in Nanoparticle Fabrication and Biodiesel Synthesis (2008)

The current research is an attempt to combine reactions in a domestic microwave oven (DMO) with a circulating pump in order to create a continuous circulating flow microwave system. This system allows the reagents and products to circulate in and out of the microwave reactor until the end of the synthesis. In fact, this is the first attempt of its kind to build a continuous flow microwave system for production of nanosized particles. The continuous DMO system has several advantages over batch microwave ovens, such as its ability to work with large quantities of reagents, the possibility to withdraw samples of the product without stopping the process, and the constant stirring of the reagents during the reaction. Various nanoparticles with different particle sizes were prepared. Another reaction that was tested in this study was the synthesis of biodiesel. Complete conversion of commercially available vegetable oils to fatty-acid esters and glycerol was accomplished in the newly designed system.
Posing polygonal objects in the plane by pushing (2003)

The authors study the use of pushing actions with a fence to orient and translate objects in the plane. They describe a planner which a guaranteed to construct a sequence of pushing actions to move any polygonal object from any initial configuration to any final configuration. This planner, which utilizes an analysis of the mechanics of pushing an object, generates open-loop plans which do not require feedback sensing. These plans are guaranteed to succeed provided certain physical assumptions are met. Results of experiments conducted to demonstrate the generated plans are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Definition Servomotor (2017)

„Was genau ist eigentlich ein Servomotor?“. Diese Frage kann selbst Experten in Verlegenheit bringen. Im Folgenden werden daher einige Begriffe rund um den Begriff Servomotor erläutert.
Optimization of HIV-1 Envelope DNA Vaccine Candidates within Three Different Animal Models, Guinea Pigs, Rabbits and Cynomolgus Macaques (2013)

HIV-1 DNA vaccines have many advantageous features. Evaluation of HIV-1 vaccine candidates often starts in small animal models before macaque and human trials. Here, we selected and optimized DNA vaccine candidates through systematic testing in rabbits for the induction of broadly neutralizing antibodies (bNAb). We compared three different animal models: guinea pigs, rabbits and cynomolgus macaques. Envelope genes from the prototype isolate HIV-1 Bx08 and two elite neutralizers were included. Codon-optimized genes, encoded secreted gp140 or membrane bound gp150, were modified for expression of stabilized soluble trimer gene products, and delivered individually or mixed. Specific IgG after repeated i.d. inoculations with electroporation confirmed in vivo expression and immunogenicity. Evaluations of rabbits and guinea pigs displayed similar results. The superior DNA construct in rabbits was a trivalent mix of non-modified codon-optimized gp140 envelope genes. Despite NAb responses with some potency and breadth in guinea pigs and rabbits, the DNA vaccinated macaques displayed less bNAb activity. It was concluded that a trivalent mix of non-modified gp140 genes from rationally selected clinical isolates was, in this study, the best option to induce high and broad NAb in the rabbit model, but this optimization does not directly translate into similar responses in cynomolgus macaques.
Resonant ac Dipolar Excitation for Ion Motion Control in the Orbitrap Mass Analyzer (2006)

A dipolar ac signal applied to the split outer electrode of an Orbitrap mass spectrometer at the axial resonance frequency causes excitation of ion axial motion and either eventual ion ejection from the trap, if applied in phase with ion motion, or de-excitation, if applied 180 degrees out of phase. Both de-excitation and excitation may be achieved mass-selectively. The extent of ion axial de-excitation depends on the ac amplitude and on the number of cycles applied; sufficient de-excitation can be accomplished such that the ion signal cannot be observed above baseline noise. After de-excitation, the ions remain trapped and in rapid orbital (but not axial) motion, which allows them to be re-excited coherently by application of a second ac waveform allowing the signal again to be observed. Both broad-band and narrow-band waveforms have been used to de-excite and to re-excite ion motion. Using narrow-band waveforms, selective de-excitation and re-excitation can be performed with unit mass selection, leaving an adjacent 13C isotopic peak unaffected. The origin and potential applications of these new capabilities is delineated.