gebhart/patrepeval huggingface dataset:
Use of multilocus enzyme electrophoresis to examine genetic relationships amongst isolates of Mycobacterium intracellulare and related species (1997)

As part of a larger study investigating diversity and distribution of Mycobacterium spp. in Australia, multilocus enzyme electrophoresis was used to assess genetic relationships at 17 enzyme loci amongst a collection of reference strains and isolates initially identified on biochemical and other grounds as M. intracellulare (70), "X' mycobacteria (10), M. scrofulaceum (7), M. avium (8) and M. avium subsp. paratuberculosis (2). Two of the isolates initially identified as M. intracellulare were shown to be quite distinct from the others. Both gave negative results in a species-specific DNA probe test, whilst one was positive by PCR. These results emphasize the uncertainties involved in identifying members of this group. The other M. intracellulare isolates formed a cohesive but diverse group, being divided into 48 electrophoretic types (ETs), with a mean genetic diversity of 0.38. Forty-three of these ETs contained only single isolates. There was no clear relationship between the serovar and ET designation. The index of association calculated for M. intracellulare was significantly different from zero, suggesting that it is a clonal species. PFGE was also applied to selected isolates from the ETs containing multiple isolates, and some of these could be differentiated further. The strains of M. scrofulaceum and "X' mycobacteria were distinct from M. intracellulare, but themselves were highly heterogeneous, with mean genetic diversities of 0.66 and 0.65, respectively. Each of these groups may represent more than one species. M. avium strains were distinct from the two M. avium subsp. paratuberculosis strains, as well as from the other mycobacteria studied.
Combination of the Histone Deacetylase Inhibitor Vorinostat and Dasatinib Increases Apoptosis in Bcr-abl+ Cells and Reverses Changes Associated with CML Progression. (2006)

Abstract Chronic myelogenous leukemia (CML) is associated with the bcr-abl fusion gene product, a constitutively active non-receptor tyrosine kinase driving cell division. The potent bcr-abl kinase inhibitor, dasatinib, is now FDA approved for imatinib-refractory patients, being active in most cases other than those with the T315I mutation. However, accelerated phase CML is typified by further genetic changes, including the suppression of various DNA damage response and apoptosis related proteins (Radich, et al PNAS 2006). Thus a novel approach which may reverse these changes, might provide better treatment of accelerated phase CML. A new class of agents targeting epigenetic processes, the histone deacetylase inhibitors (HDACi), is believed to act upon chromatin allowing re-expression of tumor suppressor genes believed to be closed off to transcription by the tumor in its effort to grow in an uncontrolled manner. We reasoned that adding an HDACi to dasatinib treatment of CML cells could promote re-expression of genes responding to genetic instability in these cells. To test this hypothesis we tested dasatinib (D) and the HDACi Vorinistat (V, suberoylanilide hydroxamic acid, SAHA) alone and in combination, using K562 cells. Apoptosis was measured by Annexin V staining after 48 hours. Apoptosis results: 1uM Vorinostat: 10%; 2 uM V: 16%. Dasatinib 0.5 nM: 28%, 1 nM D: 44% In combination, 1uM V + 0.5 nM D: 41%, 1 uM V + 1nM D: 64%, 2 uM V + 0.5 nM D: 65%, 2 uM V + 1 nM D: 67%, suggesting significant increase in apoptosis for the combination over either single agent treatment alone. We therefore began surveying panels of DNA damage- and apoptosis-related genes by means of RT-PCR. Studying the combination of 2 uM V + 1 nM D, we found increased expression of several proteins, including GADD45G and FANCG, both DNA damage response proteins suppressed in the progression to accelerated phase CML. Other proapoptotic proteins were increased such as MAP2K6, SEMA4A, BIK, and TNF superfamily members 7 and 25. This data suggests that the changes associated with progression from chronic phase to accelerated and blast crisis CML may be epigenetic in nature, and that these changes may be reversed by the combination of vorinostat and dasatinib. A clinical trial of dasatanib and vorinostat in advanced phase CML would be of value.
Data from: Stimulation of the pelvic nerve increases bladder capacity in the Prostaglandin E2 rat model of overactive bladder (2022)

This dataset contains data used for the publication: Langdale et al. 2017 (DOI:10.1152/ajprenal.00116.2017). The abstract for that paper is as follows: Original Paper Abstract: Overactive bladder (OAB) syndrome is a highly prevalent condition that may lead to medical complications and decreased quality of life. Emerging therapies focusing on selective electrical stimulation of peripheral nerves associated with lower urinary tract (LUT) function may provide improved efficacy and reduced side effects compared to sacral neuromodulation for the treatment of OAB symptoms. Prior studies investigating the effects of pelvic nerve (PelN) stimulation on LUT function were focused on promoting bladder contractions, and it is unclear if selective stimulation of the PelN would be beneficial for the treatment of OAB. Therefore, our motivation was to test the hypothesis that PelN stimulation would increase bladder capacity in the prostaglandin E2 (PGE2) rat model of OAB. The effects of intravesical PGE2 vs. vehicle and PelN stimulation after intravesical PGE2 on cystometric parameters were quantified in 17 urethane-anesthetized female Sprague-Dawley rats. Intravesical infusion of PGE2 resulted in decreased bladder capacity and increased voiding efficiency without a change in bladder contraction area under the curve, maximum contraction pressure, or contraction duration. Bladder capacity was also significantly decreased compared to vehicle confirming that the change in bladder capacity was mediated by PGE2. PelN stimulation reversed the PGE2-induced change in bladder capacity and increased the EUS EMG activity at a specific stimulation condition (1.0T amplitude at 10 Hz). These results confirm that the urodynamic changes reported in conscious rats are also observed under urethane anesthesia and that PelN stimulation is a novel and promising approach for the treatment of the symptoms of OAB.
Supplemental Table 1 from MR-Guided Near-Infrared Spectral Tomography Increases Diagnostic Performance of Breast MRI (2023)

&lt;p&gt;Supplemental Table 1. Complete optical data from 30 analyzed patients.&lt;/p&gt;
A New Model for the Estimation of Breast Cancer Risk (2000)

Abstract : Cancer risk is the probability that cancer will occur in a given population. Research on cancer risk seeks to identify populations with a high probability of developing cancer. The goal of this research is to merge a computerized analysis of mammograms, which characterizes the breast pattern, with information of a woman's personal and family histories into a novel model for use in estimating risk of breast cancer. We have shown that computer-extracted features of mammographic parenchymal patterns can be used in the prediction of breast cancer risk. This has been demonstrated using three approaches: (1) correlation with clinical models of Gail and Claus, (2) separation between women at low risk and those with a positive gene testing result, and (3) separation between women at low risk and those that have breast cancer. In addition, we have shown, that the inclusion of the mammographic features with age increase the predictive power over the use of age alone in the prediction of breast cancer risk. We have also shown that with our method, the performance of the features and the classifier are quite dependent on ROl location within the breast and only slightly dependent on ROl size.
Alteration of lysophosphatidylcholine content in low density lipoprotein after oxidative modification: relationship to endothelium dependent relaxation (1994)

The raised lysophosphatidylcholine level in oxidatively modified LDL was related to the ability of the LDL to impair endothelium dependent relaxation. However, lipid peroxidation products assessed by TBARS did not relate to the phospholipid changes in LDL and therefore cannot be used to predict the vascular effects of LDL after oxidative modification.
An anti-skid braking system for aircraft via Mixed-Slip-Deceleration control and Sliding Mode Observer (2017)

For both safety and technological reasons, aircraft anti-skid control systems are typically based on the wheel speed measurement only, which yields a self-contained landing-gear subsystem, but makes the anti-skid performance sub-optimal. For a better exploitation of the available tire-runway grip, a modulating control technique is herein proposed: it ensures improved closed-loop properties but requires the estimation of the aircraft velocity, which cannot be directly measured. In this paper, an aircraft landing gear control-oriented model is presented considering the distinctive effect of the gear walk dynamics. A Mixed Slip and Deceleration anti-skid controller is introduced to suitably leverage the runway available grip. Then, a Sliding Mode Observer is proposed to estimate aircraft wheel slip and, based on a non linear curve fitting procedure, it allows also to retrieve road friction conditions. Finally, simulation results of the implemented model are shown in order to quantitatively asses the combined estimation and control performance.
Performance Enhancement in Ultra-Scaled SONOS FinFlash by Inclusion of High-k Dielectric in the Gate Stack (2008)

This paper presents the technological process and electrical behaviour of SONOS FinFlash devices fabricated on silicon-on-insulator (SOI) substrates and including HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> in the inter poly dielectric (IPD). Using trimming techniques, ultra-scaled devices were processed with aggressive dimensions down to 10 nm channel width and 30 nm gate length. Good performances are obtained in Fowler-Nordheim (FN) operation on these structures.
Supplementary Figure 8 from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors (2023)

&lt;p&gt;PDF file - 184K, EMD 1214063 and EMD 1204831 display anti-tumor activity in HGF-dependent and HGF-independent xenograft tumor models. Mice bearing subcutaneous tumors derived from the human gastric Hs746T cell line (A and B) or the glioblastoma U87MG cell line (C and D) were administered daily the indicated doses of EMD 1214063 (A and C), EMD 1204831 (B and D), or vehicle for the indicated treatment duration. Each data point represents the mean � SD of the calculated tumor volumes observed in experimental groups including ten mice. Statistical significance was evaluated by one-way ANOVA (Kruskal-Wallis, Dunn's post test). Asterisks indicate statistically significant differences between treated and control experimental groups (P≤0.05).&lt;/p&gt;
Impact of anatomical fractionation of corn stover on hammer mill throughput and energy consumption (2022)

The goal of this Case Study was to quantify the impacts of variable moisture and ash on hammer mill throughput and energy consumption and on loss of very wet stover that causes failures in the first stage grinder and that are not able to be fed to conversion, as compared to a status quo Base Case system. Also considered was convertible carbohydrate content (minimum total carbohydrate specification) and maximum ash content and the delivered feedstock cost impacts of not being able to feed stover not meeting the total carbohydrate specification to the conversion reactor. Laboratory data on the impacts of moisture content and tissue fraction on throughput and energy consumption in a stage 2 hammer mill were received from FCIC Subtask 5.1. Additional air classifier throughput, energy consumption and separation efficiency data were obtained from FCIC Subtask 5.1 for the new air classifier, which has three exit streams (lights, middle and heavies). These data were utilized to develop the necessary response surface equations to perform throughput analysis using discrete event simulation. Because the ash contents and particle sizes had not been analyzed in the laboratory at the time of the model runs, we assumed that the ash distributed proportionally with total mass into the lights and heavies in an air classifier having two exit streams (lights and heavies) and that the lights fraction from the air classifier was not removed. Key takeaways from this Case Study are that due to lower energy consumption, it is more cost effective to hammer mill fractionated corn stover tissues than whole stover. Reduction of grinding energy was significant and may possibly be connected to particle-particle interactions in the grinder that lead to increased residence time of leaves and husks, resulting in decreased throughput and higher generation of fines when milling whole stover. While we did not see significant impacts to throughput, this was due to moisture failures of the first stage grinder in each system dominating failures and downtime. The operating cost savings of reduced grinding energy savings in the second stage hammer mills alone was high enough to offset the added capital cost of the air classifier and extra grinding line.
Addition of the osmium-methylene bond in Os3(CO)11(.mu.-CH2) to bis(triphenylphosphine)platinum to give the spiked triangular cluster Os3Pt(.mu.-CH2)(CO)11(PPh3)2. NMR investigation of the fluxional properties of Os3(CO)11(.mu.-CH2) (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAddition of the osmium-methylene bond in Os3(CO)11(.mu.-CH2) to bis(triphenylphosphine)platinum to give the spiked triangular cluster Os3Pt(.mu.-CH2)(CO)11(PPh3)2. NMR investigation of the fluxional properties of Os3(CO)11(.mu.-CH2)Gregory D. Williams, Marie Chantal. Lieszkovszky, Chad A. Mirkin, Gregory L. Geoffroy, and Arnold L. RheingoldCite this: Organometallics 1986, 5, 11, 2228–2233Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://pubs.acs.org/doi/10.1021/om00142a010https://doi.org/10.1021/om00142a010research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Solid-state amperometric NO{sub x} sensor using sodium ion conductor (1996)

There has been a growing awareness of the need for in situ NO{sub x} (NO and NO{sub 2}) monitoring in combustion exhausts and environmental atmosphere. Several solid-electrolyte NO{sub x} sensors have so far been proposed and examined. These sensor devices, mostly of potentiometric type fabricated by using a couple of solid electrolyte/nitrate auxiliary phase (Type III). The authors have reported that a NASICON (sodium ion conductor)/nitrite couple shows excellent sensing characteristics, especially to NO{sub 2}. However, there has been little work on solid-state amperometric NO{sub x} sensors though it is known that amperometry, if properly fabricated, can give more precise concentration data in a limited concentration range than potentiometry. In this study, an attempt was made for an amperometric NO{sub x} sensor device using a NASICON/nitrite (or nitrate) couple.
Latent Semantic Indexing Model for Boolean Query Formulation (2000)

A new model named Boolean Latent Semantic Indexing model based on the Singular Value Decomposition and Boolean query formulation is introduced. While the Singular Value Decomposition alleviates the problems of lexical matching in the traditional information retrieval model, Boolean query formulation can help users to make precise representation of their information search needs. Retrieval experiments on a number of test collections seem to show that the proposed model achieves substantial performance gains over the Latent Semantic Indexing model.
Total synthesis of a highly oxygenated quassinoid, (.+-.)-klaineanone (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of a highly oxygenated quassinoid, (.+-.)-klaineanonePaul A. Grieco, David T. Parker, and Ravi P. NargundCite this: J. Am. Chem. Soc. 1988, 110, 16, 5568–5569Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/ja00224a050https://doi.org/10.1021/ja00224a050research-articleACS PublicationsRequest reuse permissionsArticle Views417Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Influence of the Counterion on the Synthesis of ZnO Mesocrystals under Solvothermal Conditions (2011)

Polymers and coordinating solvents have been shown to serve as templating agents to assist the precipitation of ZnO nanoparticles and address their morphology. In this work we show for the first time that a difference in the coordination strength between the polymer (poly-N-vinylpyrrolidone (PVP)) and the two Zn(II) precursor salts (nitrate and acetate) is able to promote or suppress the formation of mesocrystalline structures and even more importantly to tune their three-dimensional organization. On the basis of FTIR and (13)C NMR spectroscopic studies, we propose that not only the polymer (PVP) but also the solvent (DMF) play a key role as directing agents.
X-ray Radiography Inspection of Pores of Thin Aluminum Foam during Press Forming Immediately after Foaming (2021)

Forming aluminum foam to the desired shape while retaining its pore structures is essential for manufacturing aluminum foam products. Recently, a press forming process for aluminum foam that is performed after precursor foaming but before solidification has been proposed. In this study, to track individual pores throughout press forming immediately after foaming, X-ray radiography inspection was applied. A thin precursor was used, and foaming was constrained to the X-ray transmission direction. It was shown that, although some pores coalesced with other pores, the pores did not collapse during press forming. In addition, the porosity of aluminum foam evaluated from X-ray transmission images was constant during press forming. Some pores retained their shape during press forming but their position was changed by the material flow generated by press forming. These results show that by press forming before the solidification of aluminum foam, aluminum foam can be shaped without the collapse of pores.
Marine Bacteria, A Source for Alginolytic Enzyme to Disrupt Pseudomonas aeruginosa Biofilms (2019)

<i>Pseudomonas aeruginosa</i> biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one of the main components of its biofilm. Targeting this major biofilm component has emerged as a tempting therapeutic strategy for tackling biofilm-associated bacterial infections. The enormous potential in genetic diversity of the marine microbial community make it a valuable resource for mining activities responsible for a broad range of metabolic processes, including the alginolytic activity responsible for degrading alginate. A collection of 36 bacterial isolates were purified from marine water based on their alginolytic activity. These isolates were identified based on their 16S rRNA gene sequences. <i>Pseudoalteromonas</i> sp. 1400 showed the highest alginolytic activity and was further confirmed to produce the enzyme alginate lyase. The purified alginate lyase (AlyP1400) produced by <i>Pseudoalteromonas</i> sp. 1400 showed a band of 23 KDa on a protein electrophoresis gel and exhibited a bifunctional lyase activity for both poly-mannuronic acid and poly-glucuronic acid degradation. A tryptic digestion of this gel band analyzed by liquid chromatography-tandem mass spectrometry confirmed high similarity to the alginate lyases in polysaccharide lyase family 18. The purified alginate lyase showed a maximum relative activity at 30 °C at a slightly acidic condition. It decreased the sodium alginate viscosity by over 90% and reduced the <i>P. aeruginosa</i> (strain PA14) biofilms by 69% after 24 h of incubation. The combined activity of AlyP1400 with carbenicillin or ciprofloxacin reduced the <i>P. aeruginosa</i> biofilm thickness, biovolume and surface area in a flow cell system. The present data revealed that AlyP1400 combined with conventional antibiotics helped to disrupt the biofilms produced by <i>P. aeruginosa</i> and can be used as a promising combinational therapeutic strategy.
Effect of xylene clearance of mesenteric fat on harvest of lymph nodes after colonic resection. (1994)

Xylene clearance offers little advantage over careful traditional step-sectioning of specimens, but may be of value if the histopathologist does not do routine meticulous step-sectioning.