gebhart/patrepeval huggingface dataset:
Study of reorientational dynamics during real-time crystallization of absorbable poly(p-dioxanone) by dielectric relaxation spectroscopy (2000)

The real-time crystallization of absorbable poly(p-dioxanone) (PDS) was studied by dielectric relaxation spectroscopy. The dipole dynamic changes in the diminishing amorphous phase were investigated over a wide range of crystallization conditions. The location, shape, and magnitude of the α relaxation and the apparent activation energy were monitored and compared before and after the onset of crystallization. We observed no correlation between the degree of crystallinity and the location (hence, the most probable relaxation time, τ) of the α relaxation from just after the initiation up to the latest stages of the isothermal crystallization. However, an abrupt change in the intensity of the α process and the apparent activation energy allowed for the precise detection of the onset of crystallization. This was probably caused by a reorganization of dipole units occurring a few moments before the crystallization began. As crystallization proceeded, an asymmetric broadening of the α peak was observed that was directly influenced by the appearance of a new lower frequency process that originated in the highly confined amorphous portion located inside the spherulites. Finally, PDS crystallization kinetics determined from the changes of the relaxed permittivity with time are discussed and compared with calorimetric and optical microscopy data. © 2000 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 38: 2436–2448, 2000
Polyethers, Propylene Oxide Polymers (2000)

Abstract Propylene oxide and other epoxides under go homopolymerization to form polyethers. In industry the polymerization is started with multifunctional compounds to give a polyether structure having hydroxyl end groups. The hydroxyl end groups are utilized in a polyurethane forming reaction. This article is mainly concerned with propylene oxide and its various homopolymers that are used in the urethane industry. The polymerization of propylene oxide can be catalyzed by base (used commercially), acid (for glycol synthesis), and by coordination catalysts containing Al, Zn, or Fe as the central atom. The mechanism of base‐catalyzed polymerization is reviewed. The physical properties of poly(propylene oxide) as well as the physical methods for determining them are reviewed. Particular emphasis is placed on nmr which has yielded a wealth of information about the structure of poly(propylene oxide) and copolymers of propylene oxide and ethylene oxide.
Sensor and actuator networks - Vineyard computing: sensor networks in agricultural production (2004)

Using ethnographic research methods, the authors studied the structure of the needs and priorities of people working in a vineyard to gain a better understanding of the potential for sensor networks in agriculture. We discuss an extended study of vineyard workers and their work practices to assess the potential for sensor network systems to aid work in this environment. The major purpose is to find new directions and new topics that pervasive computing and sensor networks might address in designing technologies to support a broader range of users and activities.
Photodynamic decontamination of blood for transfusion (1995)

Currently transfused cellular components of blood are not available in a sterile form and carry a small risk of transmitting viral and parasite diseases. Using phthalocyanines and red light, lipid enveloped viruses, e.g., HIV-1, can be inactivated in red blood cell concentrates (RBCC). Under conditions leading to virus sterilization the blood borne parasites Trypanosoma cruzi (Chagas disease) and Plasmodium falciparum (malaria) could be eliminated to undetectable levels (&gt; 4 log<SUB>10</SUB> kill). RBC damage during treatment could be avoided by increasing the light fluence rate to 80 mW/cm<SUP>2</SUP>, and by including the free radical scavenger glutathione and the vitamin E derivative Trolox during light exposure. Similar sterilization of platelet concentrates was achieved with the psoralen derivative AMT and UVA light. Platelet damage due to PUVA treatment was avoided by including the plant flavonoid rutin during irradiation. It is concluded that elimination of the risk of transmitting pathogens during blood transfusion is feasible with photochemical treatments.
The First European Interdisciplinary Ewing Sarcoma Research Summit (2012)

The European Network for Cancer Research in Children and Adolescents (ENCCA) provides an interaction platform for stakeholders in research and care of children with cancer. Among ENCCA objectives is the establishment of biology-based prioritization mechanisms for the selection of innovative targets, drugs, and prognostic markers for validation in clinical trials. Specifically for sarcomas, there is a burning need for novel treatment options, since current chemotherapeutic treatment protocols have met their limits. This is most obvious for metastatic Ewing sarcoma (ES), where long term survival rates are still below 20%. Despite significant progress in our understanding of ES biology, clinical translation of promising laboratory results has not yet taken place due to fragmentation of research and lack of an institutionalized discussion forum. To fill this gap, ENCCA assembled 30 European expert scientists and five North American opinion leaders in December 2011 to exchange thoughts and discuss the state of the art in ES research and latest results from the bench, and to propose biological studies and novel promising therapeutics for the upcoming European EWING2008 and EWING2012 clinical trials.
Reducing Coherence Overheads with Multi-line Invalidation (MLI) Messages (2013)

Most multiprocessors employ coherent caches despite the overheads of doing so. As future processors will be multi-processors with elaborate cache hierarchies, the overheads of cache coherence will be an important area for efficiency improvements. This paper proposes a novel technique, called Multi-Line Invalidation (MLI) messages, to reduce an important aspect of coherence overhead - the invalidation traffic - by combining multiple traditional (single-line) invalidation messages into a single message. MLI messages can be used alongside any traditional coherence protocols. Two empirical phenomena - the coarse-grain nature of data sharing and the trend towards programs that are free of data races - enhance the utility of MLI messages.&#13;\n&#13;\nThis paper illustrates how MLI messages could be constructed and deployed alongside an existing coherence protocol. It then presents an evaluation of their effectiveness in reducing the number of invalidation messages for several benchmark programs. We find that in several cases a significant reduction in the overall address network traffic and energy consumption could be achieved without performance degradation.
Initial spreading: A fast Start-Up TCP mechanism (2013)

With most internet connections being short-lived (i.e. 10 segments), it is very tempting to enlarge the TCP Initial Window (IW). This would save two of the three RTTs needed to transfer most of the web pages through a legacy slow start. However it has been demonstrated that the bursts created by a larger IW greatly impair global performance. An intuitive solution is the TCP Pacing. By spreading the transmission over the whole RTT, Pacing smoothes the bursts and delays the congestion. While postponing congestion provides good performance for short-lived connections, it could significantly deteriorate global network performance insofar as the reaction to congestion is also delayed. This paper analyzes the weaknesses of large IW and TCP Pacing and proposes a fast Start-Up mechanism to speed up short-lived connections while preserving long-term connections. Extensive simulations and analysis demonstrate that our solution is as efficient as a larger IW would be in an uncongested network and better than current mechanisms in congested environments.
Modified Stability Checking for On-line Error Detection (2007)

The paper propose a unified error detection technique, based on stability checking, for on-line detection of delay, crosstalk and transient faults in combinational circuits and SEUs in sequential elements. The proposed method, called modified stability checking (MSC), overcomes the limitations of the earlier stability checking methods. The paper also proposed a novel checker circuit to realize this scheme. The checker is self-checking for a wide set of realistic internal faults including transient faults. Extensive circuit simulations have been done to characterize the checker circuit. A prototype checker circuit for a 1mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> standard cell array has been implemented in a 0.13mum process
Computational model of retinal photocoagulation and rupture (2009)

In patterned scanning laser photocoagulation, shorter duration (&lt; 20 ms) pulses help reduce thermal damage beyond the photoreceptor layer, decrease treatment time and minimize pain. However, safe therapeutic window (defined as the ratio of rupture threshold power to that of light coagulation) decreases for shorter exposures. To quantify the extent of thermal damage in the retina, and maximize the therapeutic window, we developed a computational model of retinal photocoagulation and rupture. Model parameters were adjusted to match measured thresholds of vaporization, coagulation, and retinal pigment epithelial (RPE) damage. Computed lesion width agreed with histological measurements in a wide range of pulse durations and power. Application of ring-shaped beam profile was predicted to double the therapeutic window width for exposures in the range of 1 - 10 ms.
Src Inhibition with Saracatinib Reverses Fulvestrant Resistance in ER-Positive Ovarian Cancer Models In Vitro and In Vivo (2012)

Saracatinib augments effects of fulvestrant by opposing estrogen-mediated Src activation and target gene expression, increasing cell-cycle arrest, and impairing survival, all of which would oppose antiestrogen resistance in these ER+ ovarian cancer models. These data support further preclinical and clinical evaluation of combined fulvestrant and saracatinib in ovarian cancer.
Assembling capacity of phosphorus/nitrogen ligands derived from bicyclic aminophosphoranes: obtaining of di- and trimetallic iron nitrosyls (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAssembling capacity of phosphorus/nitrogen ligands derived from bicyclic aminophosphoranes: obtaining of di- and trimetallic iron nitrosylsLaurence Mordenti, Jean Louis Roustan, and Jean G. RiessCite this: Organometallics 1983, 2, 7, 843–845Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/om50001a011https://doi.org/10.1021/om50001a011research-articleACS PublicationsRequest reuse permissionsArticle Views60Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Table 1 from Angiopoietin-2 Functions as a Tie2 Agonist in Tumor Models, Where It Limits the Effects of VEGF Inhibition (2023)

&lt;p&gt;PDF file - 60K, Biacore analysis of REGN910 binding to human, monkey and mouse Ang2&lt;/p&gt;
Data from A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High-Risk Bladder Cancer Patients (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Hypoxia modification improves overall survival in muscle-invasive bladder cancer patients who undergo radiotherapy. There is evidence that hypoxic tumors benefit most from hypoxia modification. The study aimed to identify or derive a hypoxia gene signature that predicts benefit from hypoxia-modifying treatment in bladder cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Published hypoxia signatures were tested and a new one derived by analyzing bladder cancer transcriptomic data from public databases. Tumor samples were available from the BCON phase III randomized trial of radiotherapy alone or with carbogen and nicotinamide (CON). Gene expression data were generated for 151 tumors using Affymetrix Human 1.0 Exon ST arrays and used for independent validation.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; A 24-gene signature was derived, which was prognostic in four of six independent surgical cohorts (&lt;i&gt;n&lt;/i&gt; = 679; meta HR, 2.32; 95% CI, 1.73–3.12; &lt;i&gt;P&lt;/i&gt; &lt; 0.0001). The signature was also prognostic in BCON patients receiving radiotherapy alone (&lt;i&gt;n&lt;/i&gt; = 75; HR for local relapse-free survival, 2.37; 95% CI, 1.26–4.47; &lt;i&gt;P&lt;/i&gt; = 0.0076). The signature predicted benefit from CON (&lt;i&gt;n&lt;/i&gt; = 76; HR, 0.47; 95% CI, 0.26–0.86; &lt;i&gt;P&lt;/i&gt; = 0.015). Prognostic significance (&lt;i&gt;P&lt;/i&gt; = 0.017) and predictive significance (&lt;i&gt;P&lt;/i&gt; = 0.058) remained after adjusting for clinicopathologic variables. A test for interaction between hypoxia status and treatment arms was significant (&lt;i&gt;P&lt;/i&gt; = 0.0094).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; A 24-gene hypoxia signature has strong and independent prognostic and predictive value for muscle-invasive bladder cancer patients. The signature can aid identification of patients likely to benefit from the addition of carbogen and nicotinamide to radiotherapy. &lt;i&gt;Clin Cancer Res; 23(16); 4761–8. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Bandwidth Enhancement for an Optical Access Link by using a Frequency Interleaved DAC (2018)

We present the experimental realization of the frequency interleaved DAC concept for an IM/DD based access link. The first open 80 GBd PAM-4 electrical eye diagram of the frequency-interleaved DAC without using post-equalization is presented.
CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3–kinase/AKT/NF-κB signaling (2003)

Multiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in the bone marrow and their egress into peripheral blood with progression to plasma cell leukemia. Our previous study defined a functional role of CD40 activation in MM cell homing and migration. In this study, we examine signaling events mediating CD40-induced MM cell migration. We show that cross-linking CD40, using either soluble CD40L (sCD40L) or anti-CD40 monoclonal antibody (mAb), induces phosphatidylinositol 3-kinase (PI3K) activity and activates its downstream effector AKT in MM.1S cells. CD40 activation also activates the MAP kinase (MEK) pathway, evidenced by phosphorylation of extracellular signal-regulated mitogen-activated protein kinase (ERK), but not c-jun amino-terminal kinase (JNK) or p38, in a dose- and time-dependent manner. Using pharmacologic inhibitors of PI3K and MEK, as well as adenoviruses expressing dominant-negative and constitutively expressed AKT, we demonstrate that PI3K and AKT activities are required for CD40-induced MM cell migration. In contrast, inhibition of ERK/MEK phosphorylation only partially (10%-15%) prevents migration, suggesting only a minor role in regulation of CD40-mediated MM migration. We further demonstrate that CD40 induces nuclear factor (NF)-kappa B activation as a downstream target of PI3K/AKT signaling, and that inhibition of NF-kappa B signaling using specific inhibitors PS1145 and SN50 completely abrogates CD40-induced MM migration. Finally, we demonstrate that urokinase plasminogen activator (uPA), an NF-kappa B target gene, is induced by CD40; and conversely, that uPA induction via CD40 is blocked by PI3K and NF-kappa B inhibitors. Our data therefore indicate that CD40-induced MM cell migration is primarily mediated via activation of PI3K/AKT/NF-kappa B signaling, and further suggest that novel therapies targeting this pathway may inhibit MM cell migration associated with progressive MM.
Adaptive entropy coded DCT coding of magnetic resonance image sequences (2002)

Compression of magnetic resonance (MR) image sequences have proved to be difficult as compared to other medical imaging modalities. Some of the factors partially responsible for this are significant amount of noise and image artifacts which are present in a 3-D MR dataset. Another factor is use of unsuitable intensity matching techniques in removal of inter-slice dependencies. In this paper we introduce an adaptive DCT coding scheme that employs a triangle-based matching (TBM) algorithm to explore the inter-slice dependencies. The proposed scheme is used to encode a heart sequence. An improvement of 0.3 dB is achieved over adaptive intra-slice schemes at low bit-rates.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Effects of age on mechanical and structural properties of myocardium of Fischer 344 rats (1989)

To determine whether the mechanical and structural characteristics of the myocardium from the left and right ventricles are comparable in the adult rat and whether aging affects the two ventricles in a similar manner, the left and right posterior papillary muscles of rats at 10-11 and 19-20 mo of age were studied in terms of function and quantitative morphology. At 10-11 mo of age, the duration of isometric contraction was shorter and resting tension higher in the right muscle than in the left muscle. Isotonic velocity of shortening and relengthening were quicker in the left, but time-to-peak shortening was faster in the right. With aging (19-20 mo), velocity of shortening fell in the left ventricle while duration of contraction became prolonged. No such age-related effects were found in the right papillary muscle. On a structural basis, myocardial damage in the form of replacement scarring was present in the left and right muscles at 10-11 mo of age. However, the left muscle was more severely injured, and this difference persisted with age because a comparable increase in replacement fibrosis occurred in both muscles. It was concluded that cardiac performance is distinctly different in the left and right papillary muscles and aging exerts its detrimental impact on the left more than in the right myocardium, an observation that is further supported by the magnitude of tissue injury.
Abstract P1-01-04: Early stage breast cancer prognostication using whole tumor or Ki67 heterogeneity-based digital imaging (2016)

Abstract Introduction: Accurate prognosis of hormone-positive early stage breast cancer patients offers the opportunity to make more informed follow-up choices, for example the addition of adjuvant chemotherapy. More recently patient prognostication based on immunohistochemistry-scored protein expression (ER, PR, Her2 and Ki67) in the ATAC trial has been described as IHC4 (C-index of 0.78). However, IHC4 clinical translation has not occurred and may be hindered by the need for a clinically-validated standardized assay as well as pathologist scoring reproducibility. To address this idea, we employed a standardized assay system and automated scoring using digital image analysis to assess either whole tumor (WT) IHC expression values or Ki67 heterogeneity (Ki67H) quantification. The goals were to 1) establish a prognostic model based on and potentially improving the IHC4 concept and 2) improve pathologist scoring reproducibility. Material and Methods: A paraffin-embedded whole tissue cohort consisting of 120 cases of hormone-positive, HER2-negative, stage I and II, breast cancer patient samples were re-stained with standardized ER, PR, HER2, and Ki67 IHC assays. Three pathologists independently scored conventional glass slides microscopically (CM) and annotated WT on H&amp;E and Ki67 heterogeneous regions on whole slide scanned images (WSI) for each case separately. The annotations were separately registered across serial stained slides and also scored via the digital pathology algorithm. Results: The mean patient age at the time of diagnosis is 63 years with a maximum follow-up of 18 years. Patients with regional and/or distal recurrence compose 26% of the cohort with a median recurrence free survival of 8.5 years. years. Clinical variables (CV) plus WT (C-index 0.74, r2 0.38) or Ki67H (C-index 0.77, r2 0.39) models improved on patient prognostication each as compared to the IHC4 plus CV (C-index 0.70, r2 0.19) in this cohort. High inter-pathologist reproducibility for the IHC score, as measured by concordance correlation coefficient was noted for Ki67H (0.90). Conclusions: Novel algorithmic scoring methodologies such as WT and Ki67H may improve on the IHC4 concept with high inter-pathology reproducibility. We are currently validating in a larger 600 patient cohort. Citation Format: Barnes M, Srinivas C, Xu C, Dean S, Singh S, Henricksen LA, Wik N, Morris D, Magliocco A, LaFleur B. Early stage breast cancer prognostication using whole tumor or Ki67 heterogeneity-based digital imaging. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P1-01-04.
Columns, Content, and the Society Collective [Notes from the Editor] (2013)

Presents the editorial for this issue of the publication.
An efficient urine peptidomics workflow identifies chemically defined dietary gluten peptides from patients with celiac disease (2021)

ABSTRACT Celiac disease (CeD) is an autoimmune disorder induced by consuming gluten proteins from wheat, barley, and rye. Glutens resist gastrointestinal proteolysis, resulting in peptides that elicit inflammation in patients with CeD. Despite well-established connections between glutens and CeD, chemically defined, bioavailable peptides produced from dietary proteins have never been identified from humans in an unbiased manner. This is largely attributable to technical challenges, impeding our knowledge of potentially diverse peptide species that encounter the immune system. Here, we developed a novel liquid chromatographic-mass spectrometric workflow for untargeted sequence analysis of the urinary peptidome. We detected 679 distinct dietary peptides, of which ~35% have a CeD-relevant T cell epitope and ~5% are known to stimulate innate immune responses. Remarkably, gluten peptides from patients with CeD qualitatively and quantitatively differ from controls. Our results provide a new foundation for understanding gluten immunogenicity, improving CeD management, and characterizing the dietary and urinary peptidomes.
Recoverable and Recyclable Chiral Organic Catalysts (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.