gebhart/patrepeval huggingface dataset:
[Diabetic complications and their features in the elderly]. (2006)

According to great increase in the number of patients with diabetes mellitus, especially in the elderly, it is important to know clinical features of diabetic complications in the elderly. In this review, we described elderly-specific clinical characteristics of diabetic complications. First, duration of diabetes in the elderly has a broad range, and as a consequence, elderly patients exhibit a remarkable heterogeneity in their complication status. Second, as acute complications, hyperglycemic coma and hypoglycemia are especially at high risk in the elderly. Third, as for chronic complications, such as retinopathy, nephropathy, neuropathy, diabetic foot, stroke as well as ischemic heart disease, several features in the elderly patients are different from those in the non-elderly. Since these complications affect both quality of life and prognosis of the elderly, understanding these elderly-specific characteristics of diabetic complications would be necessary in the management of diabetes in the elderly.
ChemInform Abstract: Examinations in the Wittig System with Regard to an Ordering Concept of Alternative Principles. (1990)

Abstract Fundamental reflections are presented as to different effects on mechanistic pathways in chemical reactions.
Tracing Active Sites in Supported Ni Catalysts during Butene Oligomerization by Operando Spectroscopy under Pressure (2016)

Supported Ni catalysts have been studied during the dimerization of butenes by operando electron paramagnetic resonance (EPR) and in situ X-ray absorption spectroscopy (XAS) at 353 K and up to 16 bar. Single NiI/NiII shuttles were identified as active sites, whereby the conversion of initial NiI to NiII by oxidative addition of butene is obviously faster than the re-reduction of NiII to NiI by reductive elimination of the C8 product, rendering the equilibrium percentage of NiI small. At p ≤ 2 bar, NiI single sites form inactive Ni0 aggregates, while this is suppressed at higher pressure (∼12 bar). A reaction mechanism is proposed.
The interaction between some serine proteinases and horse leucocyte inhibitor. (1986)

Horse blood leucocyte cytosol exhibits a broad inhibitory activity against serine proteinases. The purified inhibitor was exposed to investigated enzymes (trypsin, chymotrypsin, elastases and serine proteinase from S. aureus) for variable time and the products were analyzed by gradient polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulphate. The molar ratio I:E, association rate constants k on and inhibition constants Ki for the enzymes and inhibitor were determined. The examined elastases form stable, stoichiometric complexes with the inhibitor (Ki less than 10(-10) M), and do not undergo proteolytic degradation during 30 min incubation at 20 degrees C even at the 2-fold molar excess of the proteinases. The reactions with elastases are extremely rapid (k on greater than 10(7) M-1 s-1) and are completed within one second whereas similar reactions with chymotrypsin and trypsin are much slower (k on = 3 X 10(5) M-1 s-5 and 5 X 10(2) M-1 s-1, respectively). Serine proteinase from S. aureus neither react nor inactivates the investigated inhibitor. The complexes of the inhibitor with trypsin and chymotrypsin are digested even at a molar ratio I:E = 2:1. All these observations point out that the inhibitor from horse leucocyte cytosol is a specific and effective inhibitor of elastases.
Data from <i>Frizzled-7</i> Is Required for Wnt Signaling in Gastric Tumors with and Without <i>Apc</i> Mutations (2023)

&lt;div&gt;Abstract&lt;p&gt;A subset of patients with gastric cancer have mutations in genes that participate in or regulate Wnt signaling at the level of ligand (Wnt) receptor (Fzd) binding. Moreover, increased Fzd expression is associated with poor clinical outcome. Despite these findings, there are no &lt;i&gt;in vivo&lt;/i&gt; studies investigating the potential of targeting Wnt receptors for treating gastric cancer, and the specific Wnt receptor transmitting oncogenic Wnt signaling in gastric cancer is unknown. Here, we use inhibitors of Wnt/Fzd (OMP-18R5/vantictumab) and conditional gene deletion to test the therapeutic potential of targeting Wnt signaling in preclinical models of intestinal-type gastric cancer and &lt;i&gt;ex vivo&lt;/i&gt; organoid cultures. Pharmacologic targeting of Fzd inhibited the growth of gastric adenomas &lt;i&gt;in vivo&lt;/i&gt;. We identified Fzd7 to be the predominant Wnt receptor responsible for transmitting Wnt signaling in human gastric cancer cells and mouse models of gastric cancer, whereby Fzd7-deficient cells were retained in gastric adenomas but were unable to respond to Wnt signals and consequently failed to proliferate. Genetic deletion of &lt;i&gt;Fzd7&lt;/i&gt; or treatment with vantictumab was sufficient to inhibit the growth of gastric adenomas with or without mutations to &lt;i&gt;Apc&lt;/i&gt;. Vantictumab is currently in phase Ib clinical trials for advanced pancreatic, lung, and breast cancer. Our data extend the scope of patients that may benefit from this therapeutic approach as we demonstrate that this drug will be effective in treating patients with gastric cancer regardless of &lt;i&gt;APC&lt;/i&gt; mutation status.&lt;/p&gt;Significance:&lt;p&gt;The Wnt receptor Fzd7 plays an essential role in gastric tumorigenesis irrespective of &lt;i&gt;Apc&lt;/i&gt; mutation status, therefore targeting Wnt/Fzd7 may be of therapeutic benefit to patients with gastric cancer.&lt;/p&gt;&lt;/div&gt;
An acoustic levitation technique for the study of nonlinear oscillations of gas bubbles in liquids (1984)

First Page
Protein Intake, Metabolic Status and the Gut Microbiota in Different Ethnicities: Results from Two Independent Cohorts (2021)

Animal protein intake is associated with pre-T2D and T2D status but not with gut microbiota beta or alpha diversity, regardless of ethnicity. Gut microbial taxonomical signatures were identified, which could function as potential modulators in the association between dietary protein intake and metabolic status.
Research-Based PAM50 Subtype Predictor Identifies Higher Responses and Improved Survival Outcomes in HER2-Positive Breast Cancer in the NOAH Study (2014)

As determined by EFS and pCR, patients with HER2(+)/HER2-E tumors, or HER2(+)/RORP-high tumors, benefit substantially from trastuzumab-based chemotherapy. The clinical value of this genomic test within HER2(+) disease warrants further investigation.
MyD88‐dependent pathway is essential for the innate immunity to Enterocytozoon bieneusi (2010)

Enterocytozoon bieneusi is clinically the most significant microsporidian parasite associated with persistent diarrhoea, wasting and cholangitis in 30-50% of individuals with HIV/AIDS, as well as in malnutritional children and in the recipients of immunosuppressive therapy. However, the host immune responses to E. bieneusi have not been investigated until recently because of lack of sources of spores, cell culture system and animal models. In this study, we purified spores from heavily infected human or monkey faeces by serial salt-Percoll-sucrose-iodixanol centrifugation, and the purity of spores was confirmed by FACS and scanning electron microscopy. Exposure of dendritic cells to E. bieneusi spores induced the upregulation of the surface markers and production of pro-inflammatory cytokines. The cytokine production was independent of toll-like receptor 4, but MyD88 dependent, because dendritic cells from MyD88 knockout mice failed to secrete these pro-inflammatory cytokines, whereas dendritic cells from C3H/HeJ (a toll-like receptor 4 mutant) were activated by E. bieneusi and secreted these cytokines. Furthermore, MyD88-deficient mice were susceptible to E. bieneusi infection, in contrast to wild-type mice that resisted the infection. Collectively, the data demonstrate innate recognition of E. bieneusi by dendritic cells and the importance of MyD88-dependent signalling in resisting infection in a murine challenge model.
ChemInform Abstract: Search for Non‐Nucleoside Inhibitors of HIV‐1 Reverse Transcriptase Using Chemical Similarity, Molecular Docking, and MM‐GB/SA Scoring. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optimal adversarial strategies in learning with expert advice (2013)

We propose an adversarial setting for the framework of learning with expert advice in which one of the experts has the intention to compromise the recommendation system by providing wrong recommendations. The problem is formulated as a Markov Decision Process (MDP) and solved by dynamic programming. Somewhat surprisingly, we prove that, in the case of logarithmic loss, the optimal strategy for the malicious expert is the greedy policy of lying at every step. Furthermore, a sufficient condition on the loss function is provided that guarantees the optimality of the greedy policy. Our experimental results, however, show that the condition is not necessary since the greedy policy is also optimal when the square loss is used, even though the square loss does not satisfy the condition. Moreover, the experimental results suggest that, for absolute loss, the optimal policy is a threshold one.
Developing of Multiple-narrowband Antenna to Detect Partial Discharge-emitted Signal under Radio Communication Noise Environment (2020)

Partial discharge (PD) detection is important for high voltage equipment to monitor insulation condition. Ultra-high frequency (UHF) antenna are used as a sensor to detect PD-emitted electromagnetic wave in the UHF band. However, some radio communication and broadcasting signals could affect PD detection as noise, having line spectra. Based on this reason, the authors developed a multiple narrowband (MNB) antenna, which can eliminate the interference of the communication frequencies, selectively. In this paper, PD detection and noise elimination abilities of the MNB antenna are investigated by measuring PD in SF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> gas under the radio communication noise. The measurement results demonstrated that the MNB antenna is suitable to detect PD under the communication noise.
Characterization of Cytotoxic T Lymphocyte Function After Foot-and-Mouth Disease Virus Infection and Vaccination (2013)

The induction of neutralizing antibodies specific for foot-and-mouth disease virus (FMDV) has been the central goal of vaccination efforts against this economically important disease of cloven-hoofed animals. Although these efforts have yielded much success, challenges remain, including little cross-serotype protection and inadequate duration of immunity. Commonly, viral infections are characterized by induction of cytotoxic T lymphocytes (CTL), yet the function of CTL in FMDV immunity is poorly defined. We developed an assay for detection of CTL specific for FMDV and reported that a modified adenovirus-vectored FMDV vaccine could induce CTL activity. This allowed us to determine whether FMDV-specific CTL responses are induced during infection and to test further whether vaccine-induced CTL could protect against challenge with FMDV. We now show the induction of antigen-specific CTL responses after infection of swine with FMDV strain A24 Cruizero. In addition, we developed a vaccination strategy that induces FMDV-specific CTL in the absence of significant neutralizing antibody. Animals vaccinated using this protocol showed delayed clinical disease and significantly suppressed viremia compared to control animals, suggesting a role for CTLs in the control of virus shedding. These results provide new insights showing induction of CTL responses to FMDV following infection or vaccination, and create the potential for improving vaccine performance by targeting cellular immunity.
Understanding Public Policy through its Instruments (2007)

Public policy instrumentation and its choice of tools and modes of operation are treated either as a kind of evidence (governing means making regulations, taxing, entering into contracts, communicating, etc.) or as if the questions it raises (the properties of instruments, justifications for choosing them, their applicability, etc.) are part of a rationality of methods without any autonomous meaning. This paper aims to explain the significance of a political sociology approach to public policy instruments in accounting for processes of public policy change: (1) public policy instrumentation is a major issue in public policy, since it reveals a (fairly explicit) theorization of the relationship between the governing and the governed: every instrument constitutes a condensed form of knowledge about social control and ways of exercising it; and (2) instruments at work are not neutral devices: they produce specific effects, independently of the objective pursued (the aims ascribed to them), which structure public policy according to their own logic. \n
Phosphokinome Analysis of Barth Syndrome Lymphoblasts Identify Novel Targets in the Pathophysiology of the Disease (2018)

Barth Syndrome (BTHS) is a rare X-linked genetic disease in which the specific biochemical deficit is a reduction in the mitochondrial phospholipid cardiolipin (CL) as a result of a mutation in the CL transacylase tafazzin. We compared the phosphokinome profile in Epstein-Barr-virus-transformed lymphoblasts prepared from a BTHS patient with that of an age-matched control individual. As expected, mass spectrometry analysis revealed a significant (>90%) reduction in CL in BTHS lymphoblasts compared to controls. In addition, increased oxidized phosphatidylcholine (oxPC) and phosphatidylethanolamine (PE) levels were observed in BTHS lymphoblasts compared to control. Given the broad shifts in metabolism associated with BTHS, we hypothesized that marked differences in posttranslational modifications such as phosphorylation would be present in the lymphoblast cells of a BTHS patient. Phosphokinome analysis revealed striking differences in the phosphorylation levels of phosphoproteins in BTHS lymphoblasts compared to control cells. Some phosphorylated proteins, for example, adenosine monophosphate kinase, have been previously validated as bonafide modified phosphorylation targets observed in tafazzin deficiency or under conditions of reduced cellular CL. Thus, we report multiple novel phosphokinome targets in BTHS lymphoblasts and hypothesize that alteration in the phosphokinome profile may provide insight into the pathophysiology of BTHS and potential therapeutic targets.
Characterization of a Periplasmic ATP-Binding Cassette Iron Import System of Brachyspira ( Serpulina ) hyodysenteriae (1999)

The nucleotide sequence of the pathogenic spirochete Brachyspira hyodysenteriae bit (for "Brachyspira iron transport") genomic region has been determined. The bit region is likely to encode an iron ATP-binding cassette transport system with some homology to those encountered in gram-negative bacteria. Six open reading frames oriented in the same direction and physically linked have been identified. This system possesses a protein containing ATP-binding motifs (BitD), two hydrophobic cytoplasmic membrane permeases (BitE and BitF), and at least three lipoproteins (BitA, BitB, and BitC) with homology to iron periplasmic binding proteins. These periplasmic binding proteins exhibit lipoprotein features. They are labeled by [(3)H]palmitate when tested in recombinant Escherichia coli, and their signal peptides are typical for substrates of the type II secretory peptidase. The FURTA system and Congo red assay indicate that BitB and BitC are involved in iron binding. The Bit system is detected only in B. hyodysenteriae and is absent from B. innocens and B. pilosicoli.
Generative networks as inverse problems with Scattering transforms (2018)

Generative Adversarial Nets (GANs) and Variational Auto-Encoders (VAEs) provide impressive image generations from Gaussian white noise, but the underlying mathematics are not well understood. We compute deep convolutional network generators by inverting a fixed embedding operator. Therefore, they do not require to be optimized with a discriminator or an encoder. The embedding is Lipschitz continuous to deformations so that generators transform linear interpolations between input white noise vectors into deformations between output images. This embedding is computed with a wavelet Scattering transform. Numerical experiments demonstrate that the resulting Scattering generators have similar properties as GANs or VAEs, without learning a discriminative network or an encoder.
Photoswitchable nanoparticles for in vivo cancer chemotherapy (2013)

There are many obstacles to effective cancer chemotherapy, including drug penetration and accumulation in tumors and drug systemic toxicity. The penetration of therapies into tumors is limited by the dense tumor matrix and by compression of the tumor vasculature. We have developed spiropyran-based nanoparticles that shrink from 103 to 49 nm upon irradiation at 365 nm. That shrinkage enhanced tissue penetration and drug release. Irradiation of s.c. HT-1080 tumors in nude mice administered i.v. docetaxel-containing nanoparticles was more effective treatment than free docetaxel or encapsulated docetaxel without irradiation. Irradiation at the tumor site also resulted in less systemic toxicity than if the nanoparticles were irradiated before injection, presumably because of less systemically distributed free drug. The enhanced efficacy of nanoparticles in irradiated tumors may have been related to the observed enhanced tumor penetration by nanoparticles and decompression of tumor blood vessels, which may also increase nanoparticle delivery into tumors.
Location of Ge and extra-framework species in the zeolite ITQ-24 (2015)

The germanosilicate ITQ-24 (IWR framework type) was synthesized in fluoride medium using 1,3,5-tris(1,2-dimethylimidazolium) benzene as the structure directing agent (SDA). A structure analysis of the as-synthesized ITQ-24 material using synchrotron powder diffraction data and difference electron density calculations have allowed the fluoride ions and the germanium atoms to be located and the conformation of the SDA to be determined. The benzyl ring is perpendicular to the b axis with the three imidazolium moieties forming a "T-shaped" arrangement. Ge atoms replace some of the Si in the double-4-ring (d4r) and in one of the single-4-rings (s4r). The other s4r contains only Si. Fluoride ions are in the d4r units. Initially, the space group Cmmm (highest possible symmetry) was assumed, but the framework geometry was strained. An independent evaluation of the symmetry using the powder charge flipping algorithm in Superflip led to a successful refinement with reasonable geometry and a refined composition of |[(C6H3)(C7H10N2)3]2F2|[Si(40.2)Ge(15.8)O112] in the space group Pban.
ADAR1 Is Involved in the Regulation of Reprogramming Human Fibroblasts to Induced Pluripotent Stem Cells (2013)

Adenosine-to-inosine (A-to-I) RNA editing is a post-transcriptional, site-specific modification process that is catalyzed by Adenosine Deaminase Acting on RNA (ADAR) gene family members. Since ADARs act on double-stranded RNA, most A-to-I editing occurs within repetitive elements, particularly Alu elements, as the result of the inherent property of these sequences to fold and form double strands. ADAR1-mediated A-to-I RNA editing was recently implicated in the regulation of human embryonic stem cells (hESCs). Spontaneous and neuronal differentiation of hESC was shown to result in a decrease in A-to-I editing levels. Knockdown of ADAR1 in hESCs results in an elevation of the expression of differentiation-related genes. In addition, we found that hESCs over-expressing ADAR1 could not be generated. The current study shows that the editing levels of induced pluripotent stem cells (iPSCs) change throughout reprogramming, from a source cell level to a level similar to that of hESCs. Up- or down-regulation of the ADAR1 level in human foreskin fibroblast (HFF) cells before induction of reprogramming results in varied reprogramming efficiencies. Furthermore, HFF-iPSC early clones derived from source cells in which the ADAR1 level was down-regulated lose their iPSC properties shortly after iPSC colony formation and instead exhibit characteristics of cancer cells. Taken together, our results imply a role for ADAR1 in the regulation of pluripotency induction as well as in the maintenance of early iPSC properties.
Integration of participatory approaches, systems, and solutions using IoT and AI for designing smart community (2019)

The present era witnessed the encroachment of Information and Communication Technology (ICT) in all aspects of human life and it is changing the living conditions. By discovering new ways of using ICT for economic, social and cultural progress, communities around the world are transforming into smart communities through addressing the needs of their inhabitants. The key verticals that define a smart community include smart governance, smart energy, smart building, smart mobility, smart infrastructure, smart technology, smart healthcare, and smart citizen. Internet of Things (IoT) and Artificial Intelligence (AI) are bringing in smartness to all these key verticals with the participation of different stakeholders. This talk will focus on discussing the unique requirements and challenges in building and implementing the smart city solutions in a few case scenarios in India in the thematic areas of energy, water, environment, disaster, skill development, livelihood, etc. It will also demonstrate how the interplay of different factors such as social, economic, political, and technological has contributed to shaping these solutions to provide improved quality of life, enhanced resilience, optimal resource utilization, empowerment of the community and achieving sustainable development.
Study of a solar concentrator for space based on a diffractive/refractive optical combination (2012)

This paper presents a new design of a planar solar concentrator at 10× with spectral splitting focusing on two separated PV cells, allowing independent control. Optical elements, blazed diffraction grating and Fresnel lens, are optimized.
Unified Scaling Laws for Routed Language Models (2022)

The performance of a language model has been shown to be effectively modeled as a power-law in its parameter count. Here we study the scaling behaviors of Routing Networks: architectures that conditionally use only a subset of their parameters while processing an input. For these models, parameter count and computational requirement form two independent axes along which an increase leads to better performance. In this work we derive and justify scaling laws defined on these two variables which generalize those known for standard language models and describe the performance of a wide range of routing architectures trained via three different techniques. Afterwards we provide two applications of these laws: first deriving an Effective Parameter Count along which all models scale at the same rate, and then using the scaling coefficients to give a quantitative comparison of the three routing techniques considered. Our analysis derives from an extensive evaluation of Routing Networks across five orders of magnitude of size, including models with hundreds of experts and hundreds of billions of parameters.