gebhart/patrepeval huggingface dataset:
IFNL3 polymorphisms are associated with COPD severity and outcomes (2017)

<b>Introduction:</b> Interferon lambda (IFNL) has an important anti-viral/bacterial and immunomodulatory function in the respiratory tract. However, the impact of IFNLs in the context of COPD and its exacerbations has not been explored yet. <b>Methods:</b> 520 patients with COPD were included in this prospective, observational, multicentre study. We determined the genetic polymorphisms (rs8099917 and rs12979860) within the IFNL3/4 gene region and the circulating levels of IFNL3 which were associated with disease activity and outcome. <b>Results:</b> The GG genotype of the rs8099917 SNP significantly influenced severe exacerbation rate (42% vs. 23%; p=0.032) and the time to severe exacerbation (HR=2.260; p=0.012). Compared to the TT/TG genotypes, the GG genotype was associated with more severe dyspnoea, as reflected by the rate 22% vs 42% of the modified medical research council (MMRC) score ≥ median of 3 (p=0.030). The CC genotype of the rs12979860 SNP was associated with a poorer prognosis as assessed by the BODE index ≥4 (=median; body mass index, airflow obstruction, dyspnea and exercise capacity; 46% CC vs. 36% TC vs. 20.5% TT; p=0.031). Patients with stable COPD and patients in an exacerbation phase had significantly lower circulating IFNL3 compared to healthy controls (p&lt;0.001 and p&lt;0.001, respectively). No GOLD IV patients (0/80) had detectable circulating IFNL3 compared to 3% (5/180) of the GOLD III patients and 5% (14/262) of the GOLD II patients. There was a significant correlation between circulating IFNL3 and post-bronchodilator FEV1 % predicted (r=0.098; p=0.034). <b>Conclusions:</b> IFNL3 polymorphisms may play a role in disease activity and outcomes in COPD and circulating IFNL3 appears to be associated with disease severity.
Transforming growth factor β induces aβ-responsive calcium fluxes in neurons (1995)

The beta-amyloid (a beta) peptide is a neurotoxic peptide that accumulates in the brains of Alzheimer patients, but is also present in body fluids at subnanomolar levels. The potential effects of these low levels of a beta are unclear. We have recently shown that physiologic levels of a beta increase tyrosine phosphorylation and induce increases in cytosolic calcium. The basement membrane mixture, Matrigel, is required for observation of the a beta-induced calcium response. We now show that transforming growth factor beta (TGF beta) is the active component in Matrigel eliciting the a beta/calcium response. The response to the type of TGF beta varies depending on the cell type with TGF beta 1 eliciting a beta responsiveness in olfactory neuroblasts, and TGF beta 2 eliciting a beta responsiveness in PC12 cells.
Teramac-configurable custom computing (2002)

The Teramac configurable hardware system can execute synchronous logic designs of up to one million gates at rates up to 1 megahertz. A fully configured Teramac includes half a gigabyte of RAM and hardware support for large multiported register files. The system has been built from custom FPGA's packaged in large multichip modules (MCMs). A large custom circuit (/spl sim/1,000,000 gates) may be compiled onto the hardware in approximately 2 hours, without user intervention. The system is being used to explore the potential of custom computing machinery (CCM).
Quality of life measurement in chronic otitis media: Validation of international questionnairs and assessment of the response shift (2020)

Introduction Patients with chronic otitis media (COM) often have a long period of suffering, characterised by recurrent otorrhoea, hearing loss, pain and multiple surgeries. The health-related quality of life (HRQOL) plays an increasingly important role in disease assessment. Internationally, a large number of validated questionnairs are used in English. The Chronic Otitis Media Outcome Test (COMOT-15) and the Zurich chronic middle ear inventory (ZCMEI-21) are validated and available in German.
Improving Statistical Machine Translation Using Bayesian Word Alignment and Gibbs Sampling (2013)

We present a Bayesian approach to word alignment inference in IBM Models 1 and 2. In the original approach, word translation probabilities (i.e., model parameters) are estimated using the expectation-maximization (EM) algorithm. In the proposed approach, they are random variables with a prior and are integrated out during inference. We use Gibbs sampling to infer the word alignment posteriors. The inferred word alignments are compared against EM and variational Bayes (VB) inference in terms of their end-to-end translation performance on several language pairs and types of corpora up to 15 million sentence pairs. We show that Bayesian inference outperforms both EM and VB in the majority of test cases. Further analysis reveals that the proposed method effectively addresses the high-fertility rare word problem in EM and unaligned rare word problem in VB, achieves higher agreement and vocabulary coverage rates than both, and leads to smaller phrase tables.
A tube-based robust nonlinear predictive control approach to semiautonomous ground vehicles (2014)

This paper proposes a robust control framework for lane-keeping and obstacle avoidance of semiautonomous ground vehicles. It presents a systematic way of enforcing robustness during the MPC design stage. A robust nonlinear model predictive controller (RNMPC) is used to help the driver navigating the vehicle in order to avoid obstacles and track the road centre line. A force-input nonlinear bicycle vehicle model is developed and used in the RNMPC control design. A robust invariant set is used in the RNMPC design to guarantee that state and input constraints are satisfied in the presence of disturbances and model error. Simulations and experiments on a vehicle show the effectiveness of the proposed framework.
A comparative study of ’isometric’ points for anterior cruciate ligament graft attachment (2000)

Anterior cruciate ligament (ACL) reconstruction depends critically on isometric graft placement. Unfortunately, different supposedly isometric points have been published, and no prior work has compared them to find out which are really isometric. The purpose of this study was to compare the isometry of previously published 'isometric' points for ACL reconstruction. The isometric points and knee loadings of previous studies were reproduced accurately in 12 fresh cadaveric knees. The length changes were measured through 140 degrees knee flexion, using an intra-articular suture attached to a displacement transducer. Six points had less than 1 mm length change and were located proximally in the natural ACL attachment at the posterior end of Blumensaat's line. The other seven points had length change patterns that would cause ACL graft tightening or slackening with knee flexion if they were used as the sites of bone tunnels for graft placement. This study confirms the existence of an isometric zone close to the posterior end of Blumensaat's line under several loading conditions. Other graft attachment points are less suitable for ACL reconstruction.
Efficient fault-tolerant certificate revocation (2000)

Article Efficient fault-tolerant certificate revocation Share on Authors: Rebecca N. Wright AT&T Labs - Research, 180 Park Avenue, Florham Park, NJ AT&T Labs - Research, 180 Park Avenue, Florham Park, NJView Profile , Patrick D. Lincoln SRI International, 333 Ravenswood Ave, Menlo Park, CA SRI International, 333 Ravenswood Ave, Menlo Park, CAView Profile , Jonathan K. Millen SRI International, 333 Ravenswood Ave, Menlo Park, CA SRI International, 333 Ravenswood Ave, Menlo Park, CAView Profile Authors Info & Claims CCS '00: Proceedings of the 7th ACM conference on Computer and Communications SecurityNovember 2000 Pages 19–24https://doi.org/10.1145/352600.352605Online:01 November 2000Publication History 21citation494DownloadsMetricsTotal Citations21Total Downloads494Last 12 Months3Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Dyadic Loneliness and HbA1c Levels Among Older Married Couples: Evidence From The Irish Longitudinal Study on Ageing (2021)

Abstract Loneliness is an important determinant of health and mortality among the aging population, including for cardiometabolic health. Yet research has largely focused on individual experiences of loneliness, rather than taking intimate relationships into account. However, recent studies have highlighted that the psychosocial well-being of one’s partner may impact one’s own health as well. Indeed, the stress generation hypothesis anticipates that loneliness in one partner may lead to more stressful interactions within relationships, and thus to worse health outcomes for both spouses. This is particularly true among older couples, as life events and shifting time horizons (e.g., retirement, socioemotional selectivity, reduced social networks) lead older persons to focus more time and energy on their closest relationships. Life events such as retirement may make adults’ intimate relationships – and the experiences of their partner – more salient than ever before. In this study, we use dyadic structural equation modeling to examine associations between loneliness and HbA1c levels among 1,331 older married couples from The Irish Longitudinal Study on Ageing. Further, we test whether any such associations vary by age or employment status. Results indicate that one’s own loneliness was not significantly linked with elevated HbA1c, irrespective of age or employment status. However, loneliness of a dyadic partner was significantly associated with elevated HbA1c among retired persons only. Further, this effect was not due to age, but rather to employment status itself. These findings suggest that relationship context is crucial when considering the dyadic health implications of loneliness among the older population.
Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models (2019)

Manipulating genes in hematopoietic stem cells using conventional transgenesis approaches can be time-consuming, expensive, and challenging. Benefiting from advances in genome editing technology and lentivirus-mediated transgene delivery systems, an efficient and economical method is described here that establishes mice in which genes are manipulated specifically in hematopoietic stem cells. Lentiviruses are used to transduce Cas9-expressing lineage-negative bone marrow cells with a guide RNA (gRNA) targeting specific genes and a red fluorescence reporter gene (RFP), then these cells are transplanted into lethally-irradiated C57BL/6 mice. Mice transplanted with lentivirus expressing non-targeting gRNA are used as controls. Engraftment of transduced hematopoietic stem cells are evaluated by flow cytometric analysis of RFP-positive leukocytes of peripheral blood. Using this method, ~90% transduction of myeloid cells and ~70% of lymphoid cells at 4 weeks after transplantation can be achieved. Genomic DNA is isolated from RFP-positive blood cells, and portions of the targeted site DNA are amplified by PCR to validate the genome editing. This protocol provides a high-throughput evaluation of hematopoiesis-regulatory genes and can be extended to a variety of mouse disease models with hematopoietic cell involvement.
Targeting XIAP and ARC (apoptosis repressor with caspase recruitment domain) Overcomes Imatinib Resitance In Blast Crisis CML Cells. (2010)

Abstract Abstract 3415 The advent of imatinib, a Bcr-Abl tyrosine kinase inhibitor (TKI) has revolutionized the treatment of patients with CML. Development of resistance and limited activity in blast crisis (BC) CML are evolving problems facing this therapy. We found that XIAP, a potent caspase inhibitor, is highly expressed in CML cells, in both, cell lines and patient samples. Treatment with imatinib deceased XIAP levels in imatinib-sensitive KBM5 but much less so in imatinib-resistant KBM5STI571 cells (harboring T315I mutation) suggesting that XIAP expression in CML is regulated at least in part via Bcr-Abl and that targeting XIAP may promote cell death in CML cells by circumventing imatinib resistance. To test this, we treated BC CML cells with XIAP antisense oligonucleotide (ASO) and with SMAC mimetic ABT-10 and found that inhibition of XIAP induced apoptotic cell death with similar efficacy in KBM5 cells and KBM5STI517 cells (EC50=6.3±0.3 μM and 8.4±0.4 μM at 48 hours, respectively for ABT-10). However, we noted that inhibition of XIAP by ASO induced the expression, in both KBM5 and KBM5STI571 cells, of apoptosis repressor with caspase recruitment domain (ARC) in both mRNA and protein levels but not the expression of Bcl-2 protein. ARC is a unique antiapoptotic protein. It acts through inhibiting caspases and antagonizing the activity and function of p53 and Bax. Therefore, its induction may antagonize the effect of XIAP downregulation. Indeed, inhibition of both XIAP and ARC by ASO induced significantly more cell death than inhibiting either protein alone in both KBM5 and KBM5STI cells. Furthermore, we demonstrated that XIAP inhibition induced-apoptosis was enhanced by imatinib in KBM5, but not in KBM5STI cells. Interestingly, inhibition of Bcr-Abl tyrosine kinase by imatinib not only decreased XIAP, but also suppressed ARC levels in KBM5 but had minimal effects on the levels of these proteins in KBM5STI571 cells and enforced expression of the Bcr-Abl p185 fusion protein (in HL-60 cells) greatly increased both XIAP and ARC levels. This induction was inhibited by imatinib suggesting that ARC is also a downstream target of Bcr-Abl tyrosine kinase. Therefore, imatinib enhancing XIAP inhibition induced-apoptosis in KBM5, not KBM5STI cells can be explained at least in part by its ability to decrease XIAP and ARC levels. In conclusion, XIAP is highly expressed in CML cells and upregulated by Bcr-Abl. Targeting XIAP promotes death of BC and TKI resistant CML cells. Results suggest that XIAP is a potential target in BC and TKI resistant CML cells and that XIAP inhibition-induced apoptosis is enhanced by imatinib in TKI sensitive cells and by ARC inhibition independent of cellular responses to TKIs. Inhibition of XIAP and ARC as a novel therapeutic strategy in CML warrants further investigation. Disclosures: Koller: Isis Pharmaceuticals: Employment.
New Directions in Design for Manufacturing (2004)

This paper gives an overview of research that is expanding the domain of design for manufacturing (DFM) into new and important areas. This paper covers DFM and concurrent engineering, DFM for conceptual design, DFM for embodiment design, DFM for detailed design, design for production, platform design for reducing time-to-market, design for system quality, design for life cycle costs, and design for environment. The paper concludes with some general guidelines that suggest how manufacturing firms can develop useful, effective DFM tools.
In Situ Optical Studies of Solid-Oxide Fuel Cells (2010)

Thermal imaging and vibrational spectroscopy have become important tools for examining the physical and chemical changes that occur in real time in solid-oxide fuel cells (SOFCs). Imaging techniques can resolve temperature differences as fine as 0.1 degrees C across a SOFC electrode at temperatures higher than 600 degrees C. Vibrational spectroscopy can identify molecular species and changes in material phases in operating SOFCs. This review discusses the benefits and challenges associated with directly observing processes that are important to SOFC performance and durability. In situ optical methods can provide direct insight into reaction mechanisms that can be inferred only indirectly from electrochemical measurements such as voltammetry and electrochemical impedance spectroscopy and from kinetic models and postmortem, ex situ examinations of SOFC components. Particular attention is devoted to recent advances that, hopefully, will spur the development of new generations of efficient, versatile energy-producing devices.
Cellular Network Planning via Local Regularity Optimization (2021)

We propose a cell planning method for wireless cellular networks to simultaneously balance the volume shares of the cells and to preserve their regularity. In this framework, we first optimize the base station locations to minimize the coefficient of variation (CoV)-based service demand share metric using the power Voronoi algorithm. Then, we maximize the downlink coverage probability by defining a local regularity optimization problem and solve it through particle swarm, farthest point, average point, and spatial median optimization methods. Finally, we apply the proposed methods on a real network to show how the proposed methods simultaneously minimize both CoV-based service demand share and local regularity metrics.
Effects of Gonadotrophin‐Releasing Hormone Agonists on Apoptosis of Granulosa Cells (2005)

Granulosa cells are known to contribute to maturation of oocytes, and most of the growth factors exert their action via granulosa cells. It has been established that granulosa cell death during follicular atresia and luteolysis results from apoptosis. However, the precise mechanistic pathways of granulosa cell apoptosis have not yet been defined. In this study, we determined the proportions of apoptosis in granulosa cells treated with two kinds of gonadotrophin-releasing hormone agonists (GnRHa): buserelin and leuprorelin depot. The incidences of DNA fragmentation of human granulosa cells treated with buserelin and leuprorelin were 54.33% and 39.02%, respectively. The proportions of apoptotic bodies were 6.04% and 4.29%, respectively. There was a significant difference in the proportions of DNA fragmentation between the two kinds of GnRHa-treated granulosa cells. The apoptosis pathway and associated protein expression in granulosa cells treated with GnRHa were also determined. The Bax molecule, a pro-apoptosis protein, was expressed in granulosa cells undergoing apoptosis. In contrast, Bcl-2, an anti-apoptosis protein, could not be detected in the same group of granulosa cells. The distribution of cytochrome c determined via immunostaining showed a diffuse pattern, which most likely indicated that cytochrome c was translocated from mitochondria into the cytoplasm. Western blotting showed the expressions of caspase-9 and caspase-3 in patients' granulosa cells. The GnRHa effects on granulosa cells indicated a higher incidence of DNA fragmentation and apoptotic bodies in the buserelin-treated than in the leuprorelin depot-treated group. The granulosa cells go through the mitochondria-dependent apoptosis pathway; the indicated pro-apoptosis protein Bax was expressed and induced cytochrome c release from mitochondria, which then activated caspase-9 and caspase-3 until cell death occurred.
ChemInform Abstract: Deprotonative Metalation of Ferrocenes Using Mixed Lithium—Zinc and Lithium—Cadmium Combinations. (2010)

Abstract A mixed lithium‐cadmium amide and a combination of lithium and zinc amides are reacted with a range of ferrocenes.
Reactor Sensor Surveillance Using Noise Analysis (1988)

AbstractReactor noise signals, as measured by neutron detectors and process sensors, contain information about the dynamics of the process and sensor characteristics. The extent of sensor characteristics that can be determined from such measurements depends on the sensor type, the property of the process noise exciting the sensor, and its location.
Large-Scale Geosocial Multimedia [Guest editorial] (2014)

With the advance of the Web 2.0 era came an explosive growth of geographical multimedia data shared on social network websites such as Flickr, YouTube, Facebook, and Zooomr. Location-aware media description, modeling, learning, and recommendation in pervasive social media analytics have become a key focus of the recent research in computer vision, multimedia, and signal processing societies. A new breed of multimedia applications that incorporates image/video annotation, visual search, content mining and recommendation, and so on may revolutionize the field. Combined with the popularity of location-aware social multimedia, location context data makes traditionally challenging problems more tractable. This special issue brings together active researchers to share recent progress in this exciting area. This issue highlights the latest developments in large-scale multiple evidence-based learning for geosocial multimedia computing and identifies several key challenges and potential innovations.
Chemically exfoliated transition metal dichalcogenide nanosheet-based wearable thermoelectric generators (2016)

A wearable thermoelectric generator, woven on a wristband, consisting of chemically exfoliated n- and p-type transition metal dichalcogenide nanosheets.
From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding (2018)

Herein, we demonstrate that a bottom-up approach, based on halogen bonding (XB), can be successfully applied for the design of a new type of ionic liquid crystals (ILCs). Taking advantages of the high specificity of XB for haloperfluorocarbons and the ability of anions to act as XB-acceptors, we obtained supramolecular complexes based on 1-alkyl-3-methylimidazolium iodides and iodoperfluorocarbons, overcoming the well-known immiscibility between hydrocarbons (HCs) and perfluorocarbons (PFCs). The high directionality of the XB combined with the fluorophobic effect, allowed us to obtain enantiotropic liquid crystals where a rigid, non-aromatic, XB supramolecular anion acts as mesogenic core. X-ray structure analysis of the complex between 1-ethyl-3-methylimidazolium iodide and iodoperfluorooctane showed the presence of a layered structure, which is a manifestation of the well-known tendency to segregation of perfluoroalkyl chains. This is consistent with the observation of smectic mesophases. Moreover, all the reported complexes melt below 100 °C, and most are mesomorphic even at room temperature, despite that the starting materials were non-mesomorphic in nature. The supramolecular strategy reported here provides new design principles for mesogen design allowing a totally new class of functional materials.
Region-Specific Objective Signatures of Endoscopic Surgical Instrument Motion: A Cadaveric Exploratory Analysis (2016)

<b>Objectives</b> The objective of this study was to evaluate region-specific surgical instrument kinematics among novice and experienced surgeons performing endoscopic endonasal skull base surgery. <b>Design</b> Cadaveric experimental study. <b>Setting</b> Tertiary academic center. <b>Participants</b> Two novice and two experienced surgeons performed eight endoscopic total ethmoidectomies and sphenoidotomies using an optically tracked microdebrider. <b>Main Outcome Measures</b> Time-stamped Euclidian coordinates were recorded. Cumulative instrument travel, mean linear velocity and acceleration, and mean angular velocities were calculated in the anterior ethmoid, posterior ethmoid, and sphenoid sinus regions. <b>Results</b> Mean cumulative instrument travel (standard deviation) was highest in the posterior ethmoid region for both novice and experienced surgeons (9,795 mm [1,664] vs. 3,833 mm [1,080]). There was a trend in mean linear and angular velocities, and acceleration with increasing magnitudes for experienced surgeons compared with novices. Among experienced surgeons, we observed a trend of decreasing yaw velocity during the approach to the surgical target. <b>Conclusions</b> We present a novel method of evaluating surgical instrument motion with respect to anatomical regions of the skull base during endoscopic endonasal skull base surgery. These data may be used in the development of surgical monitoring and training systems to optimize patient safety.