gebhart/patrepeval huggingface dataset:
Enhanced Selection of High Affinity DNA-Reactive B Cells Following Cyclophosphamide Treatment in Mice (2010)

A major goal for the treatment of patients with systemic lupus erythematosus with cytotoxic therapies is the induction of long-term remission. There is, however, a paucity of information concerning the effects of these therapies on the reconstituting B cell repertoire. Since there is recent evidence suggesting that B cell lymphopenia might attenuate negative selection of autoreactive B cells, we elected to investigate the effects of cyclophosphamide on the selection of the re-emerging B cell repertoire in wild type mice and transgenic mice that express the H chain of an anti-DNA antibody. The reconstituting B cell repertoire in wild type mice contained an increased frequency of DNA-reactive B cells; in heavy chain transgenic mice, the reconstituting repertoire was characterized by an increased frequency of mature, high affinity DNA-reactive B cells and the mice expressed increased levels of serum anti-DNA antibodies. This coincided with a significant increase in serum levels of BAFF. Treatment of transgene-expressing mice with a BAFF blocking agent or with DNase to reduce exposure to autoantigen limited the expansion of high affinity DNA-reactive B cells during B cell reconstitution. These studies suggest that during B cell reconstitution, not only is negative selection of high affinity DNA-reactive B cells impaired by increased BAFF, but also that B cells escaping negative selection are positively selected by autoantigen. There are significant implications for therapy.
Design, Synthesis, and Evaluation of 11C-Labeled 3-Acetyl-Indole Derivatives as a Novel Positron Emission Tomography Imaging Agent for Diacylglycerol Kinase Gamma (DGKγ) in Brain (2021)

Diacylglycerol kinase gamma (DGKγ) is a subtype of DGK enzyme, which catalyzes ATP-dependent conversion of diacylglycerol to phosphatidic acid. DGKγ, localized in the brain, plays an important role in the central nervous system. However, its function has not been widely investigated. Positron emission tomography (PET) imaging of DGKγ validates target engagement of therapeutic DGKγ inhibitors and investigates DGKγ levels under normal and disease conditions. In this study, we designed and synthesized a series of 3-acetyl indole derivatives as candidates for PET imaging agents for DGKγ. Among the synthesized compounds, 2-((3-acetyl-1-(6-methoxypyridin-3-yl)-2-methyl-1H-indol-5-yl)oxy)-N-methylacetamide (<b>9</b>) exhibited potent inhibitory activity (IC<sub>50</sub> = 30 nM) against DGKγ and desirable physicochemical properties allowing efficient blood-brain barrier penetration and low levels of undesirable nonspecific binding. The radiolabeling of <b>9</b> followed by PET imaging of wild-type and DGKγ-deficient mice and rats indicated that [<sup>11</sup>C]<b>9</b> ([<sup>11</sup>C]<b>T-278</b>) specifically binds to DGKγ and yields a high signal-to-noise ratio for DGKγ in rodent brains.
70. Systemic Administration of siRNA Against EWS-FLI1 Using a Targeted, Non-Viral Formulation Inhibits Growth in a Disseminated Murine Model of Ewing's Sarcoma (2005)

Despite aggressive therapy, 40% of patients with localized Ewing's family of tumors (EFT) and 80% of patients with detectable metastasis die due to tumor progression. More specific and effective treatments are needed, especially for high-risk cases. EWS-FLI1, the chimeric gene product of a chromosome translocation found in more than 90% of EFT, is crucial for maintaining EFT tumor growth. Endogenous expression of siRNA targeting the breakpoint of the EWS-FLI1 fusion gene (siEFBP) from a pol III promoter has previously been shown to reduce EWS-FLI1 transcript levels up to 80% and resulted in growth inhibition of the cultured EFT cell line TC135. Since EWS-FLI1 expression is tumor-specific, it serves as an excellent candidate for targeted therapy of EFT, especially metastatic disease.
Hydrogen Cracking by a Pt / Al2 O 3 Catalyst and Its Propagation to GaAs Substrates for TMGa‐TEAs Organometallic Vapor‐Phase Epitaxy (1991)

Hydrogen cracking by and supply to are investigated under various conditions. It is shown that the propagation of hydrogen reactive atoms from the catalyst to the substrate is due to the spillover effect at atmospheric pressure. The propagation properties are affected by the relative arrangement of the catalysts and the substrate, and by the conductivity of the substrate. It is also shown that the presence of TMGa and TEAs does not suppress the catalysis of . This is encouraging for the application of to the growth of by alkylarsenic organometallic vapor‐phase epitaxy.
Application of fuzzy structures analysis to aircraft panels (2001)

In 2000 a research implementation of Christian Soize’s fuzzy structures analysis procedures were implemented by Sparrow in the commercial finite element program MSC/NASTRAN [MSC Software Corp. (Los Angeles, CA)] using its direct matrix abstraction program (DMAP) capability coupled with MATLAB [Mathworks, Inc. (Natick, MA)]. The background and implementation details of the new DMAP code were recently given [AIAA paper 2001–1320, Non-Deterministic Approaches Forum, 42nd AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conf., Seattle, WA, 2001]. The present talk will describe the application of the new code to two prototypical aircraft panels: a small 0.96 by 0.19 m panel with one longitudinal stringer and a larger 1.8 by 1.2 m panel including six longitudinal stringers and four equally spaced frame stiffeners. The smaller and larger panels were modeled in NASTRAN as having approximately 7900 and 60&amp;lt;th&amp;gt;000 degrees of freedom, respectively. In these studies the attachment points between the stringers and skin were assumed to be fuzzy. Results will be described comparing the fuzzy and nonfuzzy finite element predictions to experimental vibration results. [Work supported by NASA Research Cooperative Agreement NCC-1-382.]
Study of Fatty Acids Profile and Oxidative Stability of Egg Yolk from Hens Fed a Diet Containing White Lupine Seeds Meal (2018)

The aim of this study was to evaluate the effects of different dietary inclusion of raw white lupine seed meal (WL) in diets of laying hen on fatty acids (FA) profile, health lipid indices and oxidative stability of egg yolk. A total of 160 TETRA-SL LL laying hens (30-week old) were used in a ten week trial. The laying hens were randomly assigned to four dietary treatments: control diet which contained soybean meal (C), and study diets in which soybean meal was replaced with WL at 150 g/kg (E15), 200 g/kg (E20) and 250 g/kg (E25). Each treatment was replicated 5 times with 8 birds each. The inclusion of WL in experimental diets caused a linear increase in n-6 and n-3 polyunsaturated FA (PUFA) content and a decrease in monounsaturated FA (MUFA), but it had no influence on the saturated FA (SFA) of egg yolk lipids. The data suggested that the partial replacement of soybean meal with WL of in laying hen diet it significant increase h/H (hypocholesterolemic/Hypercholesterolemic) and PUFA/SFA ratio, and decrease thrombogenic index (TI), which improves human health because of the beneficial effect on the cardiovascular system. The authors determined the concentration of a-tocopherol by high performance liquid chromatography (HPLC) and assessed the degree of oxidative degradation of lipids using the classical test based on the concentration of malondialdehyde (MDA). Inclusion of WL in diets led to increases in a-tocopherol and decrease in MDA in eggs (P [0.05). Egg storage for 20 d or 40 d led to linear reduction in egg �-tocopherol and increase of MDA content (P [0.05). The results of the present study suggest that the seeds of modern white lupine varieties can be included at 250 g/kg in layer diets as an effective substitute for soybean meal, improving fatty acids profile, health lipid indices and oxidative stability of egg yolk.
Radio Access Technology (2019)

This chapter provides detailed insights into 5G radio access technology. It includes the data rate evolution from 3G to LTE and toward 5G radio access technologies. The chapter considers waveform, access technologies, massive MIMO, and channel coding and provides frame and numerology design for the 5G system with multiple frequency layers (Sub 1 GHz, sub 6 GHz, and mmWave,) as one system. The chapter also explains detailed physical layer channel structures with necessary features and functionalities. Furthermore, the chapter will also provide the complete radio protocol design of the 5G radio access.
Supplementary Figures 5 and 6A-B from Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics (2023)

Supplementary Figures 5 and 6A-B from Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics
Multi-lingual and Multi-cultural Figurative Language Understanding (2023)

Anubha Kabra, Emmy Liu, Simran Khanuja, Alham Fikri Aji, Genta Winata, Samuel Cahyawijaya, Anuoluwapo Aremu, Perez Ogayo, Graham Neubig. Findings of the Association for Computational Linguistics: ACL 2023. 2023.
Mortality and Duration of Hemodialysis Treatment (1991)

Decrease in the average duration of hemodialysis treatment time is a continuing phenomenon. We investigated the relationship of 3-year mortality to duration of dialysis in a 1984-1985 national random sample of 600 hemodialysis patients from 36 dialysis units. Mortality was negatively associated with duration of dialysis treatments, as shown by the Cox model, adjusted for other patient and dialysis unit covariates. With adjustment for other covariates, patients receiving an average dialysis treatment duration of less than 3.5 hours had relative mortality risks of 1.17 to 2.18 compared with those with treatments longer than 3.5 hours (mortality risk of 1.0). Reverse causation (the possibility that more seriously ill patients received dialysis for a shorter time) appears unlikely. We conclude that duration of the dialysis procedure is an important element in determining patient mortality as one of the factors determining the adequacy of dialysis.
Test plan: WIPP Materials Interface Interactions Test (MIIT) (1986)

The WIPP Materials Interface Interactions Test (MIIT) multinational, cooperative, in situ experiments to be replaced in the Waste Isolation Pilot Plant (WIPP) starting in 1986. The MIIT involves the in situ evaluation of various waste package materials interactions in a repository-relevant, brine environment. The predominant emphasis in these tests is (1) to assess the performance.of defense high-level waste glass representative of that to be produced at the Defense Waste Processing Facility (DWPF), and (2) to obtain a fuller understanding of the relative behavior of this glass by comparing it to the behavior of many other high-level and transuranic glass waste forms in an Identical salt repository environment. For the purpose of ed to denote waste glass behavior this Test Plan, the term ``performance`` is used in the specific environment considered or tested. The tested glass waste forms come from various US and foreign laboratories. This assessment involves the long-term, in situ leaching and surface interactions testing in brine, in boreholes in the WIPP, at 90{degree}C. It is anticipated that segments of the WIPP MIIT will continue for as long as 5 years. All glass waste forms used in this test series are nonradioactive.
Development of practical simulation examples for power electronics circuit analysis (2012)

The Power Supply Working Group, created inside the Cooperative Study Group on “Applied Simulations of Power Electronics Systems” of IEEJ, is developing practical simulation examples of power supply circuits. The simulation examples have the following key features: (1) Parameters in the simulation examples are thoughtfully set to practical values so that one can readily carry out practical simulations. (2) One can easily understand the operation of practical circuits in contrast to that of ideal counterparts. The simulation examples, which are under development, are introduced in this paper.
Role of the Catalytic Subunit in Behavioral Phenotype of Mice with Inactivating Mutations of PRKAR1A or PRKACA (2012)

The role of the cAMP/PKA signaling in the molecular pathways involved in fear is well established. Prior studies in our lab reported that transgenic mice with a down-regulated Prkar1a gene exhibited behavioral abnormalities including anxiety and depression. Prior studies in our lab showed increased anxiety-like behavior in mice heterozygous for a null allele ofPrkar1a. We examined the role of altered PKA signaling on anxiety-like behaviors in both Prkar1a+/– and Prkaca+/– mice compared to wild-type (WT) littermates.
An update on gemcitabine, rituximab, and oxaliplatin in combination for relapsed/refractory non-Hodgkin lymphomas. (2012)

8084 Background: Relapsed/refractory non-Hodgkin lymphomas (NHL) have no standard of care. A variety of salvage chemotherapy options are available. We previously reported results of our phase II trial using gemcitabine, rituximab and oxaliplatin (GROC) in the salvage setting for relapsed/refractory NHL in which we observed an overall response rate of 58% with an incidence of grade 3-4 thrombocytopenia of 9% and neutropenic fever of 3.5%, but no grade 3-4 non-hematologic toxicities. Here we update progression free survival (PFS) and overall survival (OS) data. Methods: This phase II, single-arm, multicenter study evaluated safety and efficacy of GROC in patients with relapsed/refractory NHL. Patients were treated on a 14 day cycle. On day 1, patients with CD20+ NHL received rituximab (375 mg/m 2 ). On day 2, patients received gemcitabine (1000 mg/m 2 ) and oxaliplatin (100 mg/m 2 ). Granulocyte colony stimulating factor was given. Stem cell transplant (SCT) was considered after a minimum of 6 cycles. Results: A total of 58 patients were enrolled from the H. Lee Moffitt and the Auxilio Mutuo Cancer Centers. Ages ranged from 24 to 88 years (median 72 years). The majority of patients had an ECOG performance status of 0-1 (89%). Lymphoid neoplasms included large B-cell (79%), follicular (7%), lymphoblastic (1.8%), Burkitt (1.8%), primary mediastinal large B-cell (3.5%), and peripheral T-cell lymphoma (7%). Eighty-one percent of patients had stage III-IV disease, median IPI was 3, 40% had B-symptoms, 43% had bulky disease and 74% had an elevated LDH. Anthracycline-based therapy had been used in 91% of patients and 66% had received rituximab. Median PFS was 134 days (95% CI 115-153) and median OS was 296 days (95% CI 164-428). No difference in response was observed based on age &gt;60, IPI, LDH or albumin levels. Prior therapy with rituximab (p=0.02) and initial response to front-line therapy (p=0.04) appear to correlate with improved outcomes. Nine patients went on for SCT. Conclusions: GROC is a useful salvage regimen for relapsed/refractory NHL with minimal toxicities and good clinical efficacy. Several patients were able to be successfully mobilized, collected and transplanted post GROC therapy.
Efficient Synthesis of Isobenzofuran‐1(3H)‐ones (Phthalides) and Selected Biological Evaluations. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access the actual ChemInform Abstract, please click on HTML or PDF.
Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation (2016)

Strong epidemiologic evidence and common molecular mechanisms support an association between Alzheimer's disease (AD) and type 2-diabetes. Local inflammation and amyloidosis occur in both diseases and are associated with periodontitis and various infectious agents. This article reviews the evidence for the presence of local inflammation and bacteria in type 2 diabetes and discusses host pathogen interactions in chronic inflammatory disorders. Chlamydophyla pneumoniae, Helicobacter pylori and spirochetes are demonstrated in association with dementia and brain lesions in AD and islet lesions in type 2 diabetes. The presence of pathogens in host tissues activates immune responses through Toll-like receptor signaling pathways. Evasion of pathogens from complement-mediated attack results in persistent infection, inflammation and amyloidosis. Amyloid beta and the pancreatic amyloid called amylin bind to lipid bilayers and produce Ca(2+) influx and bacteriolysis. Similarly to AD, accumulation of amylin deposits in type 2 diabetes may result from an innate immune response to chronic bacterial infections, which are known to be associated with amyloidosis. Further research based on an infectious origin of both AD and type 2 diabetes may lead to novel treatment strategies.
METHANE AS A SOURCE OF CARBON AND ENERGY FOR LAKE PELAGIC FOOD WEBS (2003)

Water-column methane oxidation can represent a substantial carbon transformation pathway in lakes, and circumstantial evidence indicates that methane may be a potentially important source of carbon for pelagic food webs. We estimated methanotrophic bacterial production (MBP), methanotrophic bacterial growth efficiency (MBGE), heterotrophic bacterial production (HBP), primary production (PP), and the relative contribution of methanotrophic bacteria to overall bacterial biomass in three very different lakes during summer and winter. In addition, we measured stable carbon isotope ratios in particulate organic matter (POM), surface sediments, zooplankton, and methane. MBP corresponded to 0.3–7% of the organic C production by primary producers, and 0.5–17% of HBP during summer. During winter, MBP was 3–120% of HBP. MBP generally dominated the heterotrophic bacterial production at greater depths. Methanotrophic biomass was 3–11% of total bacterial biomass on a depth-integrated basis. Zooplankton were generally more depleted in 13C than POM. If phytoplankton δ13C signatures were −35 to −30‰, such as the POM signals, observed zooplankton signatures could be explained by a fraction of 5–15% methanotrophic bacteria in their diet. The results indicate that methanotrophic bacteria can provide a significant food source for zooplankton, and that methane oxidation represents a potentially important benthic–pelagic carbon and energy link in many lakes, particularly during winter. Corresponding Editor: J. B. Yavitt.
A 1-phytase type III effector interferes with plant hormone signaling (2017)

Most Gram-negative phytopathogenic bacteria inject type III effector (T3E) proteins into plant cells to manipulate signaling pathways to the pathogen's benefit. In resistant plants, specialized immune receptors recognize single T3Es or their biochemical activities, thus halting pathogen ingress. However, molecular function and mode of recognition for most T3Es remains elusive. Here, we show that the Xanthomonas T3E XopH possesses phytase activity, i.e., dephosphorylates phytate (myo-inositol-hexakisphosphate, InsP<sub>6</sub>), the major phosphate storage compound in plants, which is also involved in pathogen defense. A combination of biochemical approaches, including a new NMR-based method to discriminate inositol polyphosphate enantiomers, identifies XopH as a naturally occurring 1-phytase that dephosphorylates InsP<sub>6</sub> at C1. Infection of Nicotiana benthamiana and pepper by Xanthomonas results in a XopH-dependent conversion of InsP<sub>6</sub> to InsP<sub>5.</sub> 1-phytase activity is required for XopH-mediated immunity of plants carrying the Bs7 resistance gene, and for induction of jasmonate- and ethylene-responsive genes in N. benthamiana.
Energy Level Modification in Lead Sulfide Quantum Dot Thin Films through Ligand Exchange (2014)

The electronic properties of colloidal quantum dots (QDs) are critically dependent on both QD size and surface chemistry. Modification of quantum confinement provides control of the QD bandgap, while ligand-induced surface dipoles present a hitherto underutilized means of control over the absolute energy levels of QDs within electronic devices. Here, we show that the energy levels of lead sulfide QDs, measured by ultraviolet photoelectron spectroscopy, shift by up to 0.9 eV between different chemical ligand treatments. The directions of these energy shifts match the results of atomistic density functional theory simulations and scale with the ligand dipole moment. Trends in the performance of photovoltaic devices employing ligand-modified QD films are consistent with the measured energy level shifts. These results identify surface-chemistry-mediated energy level shifts as a means of predictably controlling the electronic properties of colloidal QD films and as a versatile adjustable parameter in the performance optimization of QD optoelectronic devices.
A role for ABCG2 beyond drug transport: Regulation of autophagy (2016)

The ABC drug transporters, including ABCG2, are well known for their ability to efflux a wide spectrum of chemotherapeutic agents, thereby conferring a multidrug-resistant phenotype. However, studies over the past several years suggest that the ABC transporters may play additional role(s) in cell survival in the face of stress inducers that are not ABCG2 substrates (i.e., nutrient deprivation, ionizing radiation, rapamycin). The mechanism by which this occurs is largely unknown. In the present study, using several cancer cell lines and their ABCG2-overexpressing sublines, we show that cells overexpressing ABCG2 were more resistant to these stressors. This resistance was associated with an elevated level of autophagy flux, as measured by a higher rate of SQSTM1/p62 degradation and greater accumulation of LC3-II when compared to parental cells. Knockdown of ABCG2 reduced autophagic activity in resistant cells to a level similar to that observed in parental cells, confirming that the enhanced autophagy was ABCG2-dependent. Moreover, using cell viability, apoptosis, and clonogenic assays, we demonstrated that the ABCG2-expressing cells were more resistant to amino acid starvation and radiation-induced cell death. Importantly, knockdown of the critical autophagy factors ATG5 and ATG7 greatly reduced cell survival, verifying that enhanced autophagy was critical for this effect. Taken together, these data indicate that autophagy induced by various stressors is enhanced/accelerated in the presence of ABCG2, resulting in delayed cell death and enhanced cell survival. This defines a new role for this transporter, one with potential clinical significance.
ChemInform Abstract: A Hetero‐Diels‐Alder Approach to Novel Thiopyran Analogues of Aprikalim, a Potassium Channel Activator. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Potential Role of Imatinib Mesylate (Gleevec, STI-571) in the Treatment of Vestibular Schwannoma (2010)

The expression of PDGFR-Q and c-Kit in VS tissue may indicate novel molecular targets involved in the development of this tumor. Direct inhibition of these molecules by Gleevec may have relevant therapeutic applications.