gebhart/patrepeval huggingface dataset:
The Effect of Progestational Agents on Male Gonadal and Pituitary Function. (1969)

s1 May 1969The Effect of Progestational Agents on Male Gonadal and Pituitary Function.J. Geller, M.D., A. Baron, B.S., V. Warburton, B. A., A. LohJ. Geller, M.D.Search for more papers by this author, A. Baron, B.S.Search for more papers by this author, V. Warburton, B. A.Search for more papers by this author, A. LohSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1062_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo determine whether cyproterone acetate, a progestational antiandrogen compound, decreased testosterone production by a direct effect on the testis or indirectly by inhibition of pituitary gonadotrophins, urinary testosterone glucuronide and luteinizing hormone were assayed at simultaneous intervals in patients with carcinoma of the prostate before and during drug therapy, 250 mg daily. The effect of cyproterone acetate on testicular function was also assessed by comparison of levels of urinary testosterone glucuronide on the third and fourth days of stimulation with human chorionic gonadotrophin before and during administration of the test drug. Urinary testosterone glucuronide was measured by gas-chromatography and luteinizing... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bronx, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNormalization of sexual behaviour in a female with dementia after treatment with cyproteroneAntiandrogens: Basic Concepts and Clinical TrialsContinuous oral low-dosage cyproterone acetate for fertility regulation in the male? — A trend analysis in 15 volunteers —AntiandrogensClinical Uses of Antiandrogens 1 May 1969Volume 70, Issue 5Page: 1062-1062KeywordsDrug administrationDrug therapyDrugsLuteinizing hormoneTestosterone Issue Published: 1 May 1969 PDF DownloadLoading ...
An Open Architecture Framework for the Integration of Virtual Prototyping Software Tools (1997)

Abstract The use of virtual prototyping tools typically results in products with lower costs, better quality, and shorter development cycles. However, there are many interface/configuration problems that occur in the process of obtaining a design solution using the typical gamut of virtual prototyping tools. This paper presents the architecture, design, and implementation of a framework to support the integration of the multiple software systems used in the virtual prototyping of mechanical components. Some of the virtual prototyping software systems considered in the implementation of this framework were customer input systems, solid modeling systems, finite-element systems, knowledge-based systems, NC code generator systems, and virtual assembly systems. There is a pressing need for the different software systems to talk to each other while transferring the required data at varying levels of abstraction without compromising data integrity. Of special significance is the fact that the philosophy of the framework is widely applicable to any mechanical system, and is almost independent of specific software utilities. Thus, this design incorporates a clear path towards expansion to encompass other independent tools/systems. The architecture was designed using object-oriented methods. The framework was very successfully demonstrated for a well-defined subset of software systems being used at Isothermal Systems Research (ISR) Inc., a leader in proprietary spray cooling systems for multi-chip modules. This framework effectively supports the strong industry push towards integrated design, manufacturing, and virtual prototyping. The work presented in this paper was supported by an SBIR grant from the Department of Commerce, DOC contract 50-DKNB-5-00117.
Self‐Assembly of a Heteropolyoxopalladate Nanocube: [PdII13AsV8O34(OH)6]8− (2008)

Not like the others: A molecular palladium oxide cluster was formed by self-assembly of palladium(II) and arsenic(V) using mild reaction conditions. The resulting heteropolypalladate [PdII13AsV8O34(OH)6]8− has a distorted cubic shape and edge lengths of about 1 nm. The thirteen PdII ions retain four-coordinate square-planar geometry, in marked contrast to all other known discrete polyoxometalates.
Proof of concept for identifying cystic fibrosis from perspiration samples (2019)

The gold standard for cystic fibrosis (CF) diagnosis is the determination of chloride concentration in sweat. Current testing methodology takes up to 3 h to complete and has recognized shortcomings on its diagnostic accuracy. We present an alternative method for the identification of CF by combining desorption electrospray ionization mass spectrometry and a machine-learning algorithm based on gradient boosted decision trees to analyze perspiration samples. This process takes as little as 2 min, and we determined its accuracy to be 98 ± 2% by cross-validation on analyzing 277 perspiration samples. With the introduction of statistical bootstrap, our method can provide a confidence estimate of our prediction, which helps diagnosis decision-making. We also identified important peaks by the feature selection algorithm and assigned the chemical structure of the metabolites by high-resolution and/or tandem mass spectrometry. We inspected the correlation between mild and severe CFTR gene mutation types and lipid profiles, suggesting a possible way to realize personalized medicine with this noninvasive, fast, and accurate method.
The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. (1978)

Mouse beta-globin in encoded in a discontinuous structural gene interrupted by a 550-base pair intervening sequence of DNA. Correspondingly, the mature beta-globin mRNA appears to be synthesized via a 15S precursor, the length of which roughly equals the total length of the coding and intervening sequences of the beta-globin gene. Using the electron microscope to visualize hybrid structures formed between this gene and the purified 15S beta-globin mRNA precursor, we show that the intervening sequence is present within the larger precursor molecule. This finding suggests that the precursor mRNA is processed through the removal and rejoining of internal RNA sequences.
Tuning Physicochemical Properties of a Macroporous Polysaccharide-Based Scaffold for 3D Neuronal Culture (2021)

Central nervous system (CNS) lesions are a leading cause of death and disability worldwide. Three-dimensional neural cultures in biomaterials offer more physiologically relevant models for disease studies, toxicity screenings or in vivo transplantations. Herein, we describe the development and use of pullulan/dextran polysaccharide-based scaffolds for 3D neuronal culture. We first assessed scaffolding properties upon variation of the concentration (1%, 1.5%, 3% <i>w</i>/<i>w</i>) of the cross-linking agent, sodium trimetaphosphate (STMP). The lower STMP concentration (1%) allowed us to generate scaffolds with higher porosity (59.9 ± 4.6%), faster degradation rate (5.11 ± 0.14 mg/min) and lower elastic modulus (384 ± 26 Pa) compared with 3% STMP scaffolds (47 ± 2.1%, 1.39 ± 0.03 mg/min, 916 ± 44 Pa, respectively). Using primary cultures of embryonic neurons from <i>PGK<sup>Cre</sup>, Rosa26<sup>tdTomato</sup></i> embryos, we observed that in 3D culture, embryonic neurons remained in aggregates within the scaffolds and did not attach, spread or differentiate. To enhance neuronal adhesion and neurite outgrowth, we then functionalized the 1% STMP scaffolds with laminin. We found that treatment of the scaffold with a 100 μg/mL solution of laminin, combined with a subsequent freeze-drying step, created a laminin mesh network that significantly enhanced embryonic neuron adhesion, neurite outgrowth and survival. Such scaffold therefore constitutes a promising neuron-compatible and biodegradable biomaterial.
Metabotyping ofCaenorhabditis elegansand their Culture Media Revealed Unique Metabolic Phenotypes Associated to Amino Acid Deficiency and Insulin-Like Signaling (2011)

Insulin/IGF-like signaling (IIS) and nutrient sensing are among the most potent regulators of health status and aging. Here, a global view of the metabolic changes in C. elegans with impaired function of IIS represented by daf-2 and daf-16 and the intestinal di- and tripeptide transport pept-1 was generated using (1)H nuclear magnetic resonance spectroscopic analysis of worm extracts and spent culture media. We showed that specific metabolic profiles were significantly associated with each type of mutant. On the basis of the metabonomics data, selected underlying processes were further investigated using proteomic and transcriptomic approaches. The observed changes suggest a decreased activity of the one carbon metabolism in pept-1(lg601) mutants. Higher concentration of branched-chain amino acids (BCAA) and altered transcript levels of genes involved in BCAA metabolism were observed in long-living strains daf-2(e1370) and daf-2(e1370);pept-1(lg601) when compared to wild types and daf-16(m26);daf-2(e1370);pept-1(lg601) C. elegans, suggesting a DAF-16-dependent mechanism.
Hemangioblastoma of the cerebellum--an immunocytochemical study. (1987)

Immunocytochemical studies using a new antibody against endothelial cells and commercially available antibodies against glial fibrillary acidic protein (GFAP) and S-100 protein were performed on 10 cerebellar hemangioblastomas in order to clarify the controversy over the origin of stromal cells. Neither cytoplasmic immunoreactivity for endothelial cell markers nor for anti-GFAP and anti-S-100 protein was found in these cells. Endothelial cell markers reacted positively only with neoplastic capillaries of the tumors and anti-GFAP and anti-S-100 protein were only found in glial remainders in the centers and margins of the tumors.
Tunable Electro-Optofluidic Resonators (2012)

We design and demonstrate electrically-enabled optofluidic devices for tuning and reconfiguring lab-on-chip photonic elements in silicon platforms. Optofluidic resonators integrated with electric microheaters for resonance tuning are demonstrated.
Three-dimensional Optical Coherence Tomographic Findings of Idiopathic Multiple Serous Retinal Pigment Epithelial Detachment (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
Characterization of ocular gland morphology and tear composition of pinnipeds (2012)

Our findings indicate that the ocular gland architecture and biochemical nature of the tear film of pinnipeds have evolved to adapt to the challenges of an aquatic environment.
Changes in Silk Feedstock Rheology during Cocoon Construction: The Role of Calcium and Potassium Ions (2018)

Variation in silk feedstocks is a barrier both to our understanding of natural spinning and biomimetic endeavors. To address this, compositional changes are investigated in feedstock specimens from the domesticated silkworm (Bombyx mori). It is found that the feedstock viscosity decreased systematically by over two orders of magnitude during cocoon construction. Potential factors such as protein concentration, molecular weight, pH, or the presence of trehalose are excluded, whereas a clear correlation appear between viscosity and the relative concentrations of Ca<sup>2+</sup> and K<sup>+</sup> ions. It is expected that Ca<sup>2+</sup> ions would favor "salt bridges" between acidic (Asp and Glu) amino acids, leading to an increased viscosity, whereas K<sup>+</sup> ions would compete for these sites, thereby reducing viscosity. Thus, these findings suggest a simple, systematic yet sophisticated control of feedstock viscosity in the silkworm, which in turn can be applied to future industrial silk production.
Ex Vivo Assessment of Tumor-Targeting Fluorescent Tracers for Image-Guided Surgery (2020)

Image-guided surgery can aid in achieving complete tumor resection. The development and assessment of tumor-targeted imaging probes for near-infrared fluorescence image-guided surgery relies mainly on preclinical models, but the translation to clinical use remains challenging. In the current study, we introduce and evaluate the application of a dual-labelled tumor-targeting antibody for ex vivo incubation of freshly resected human tumor specimens and assessed the tumor-to-adjacent tissue ratio of the detectable signals. Immediately after surgical resection, peritoneal tumors of colorectal origin were placed in cold medium. Subsequently, tumors were incubated with <sup>111</sup>In-DOTA-hMN-14-IRDye800CW, an anti-carcinoembryonic antigen (CEA) antibody with a fluorescent and radioactive label. Tumors were then washed, fixed, and analyzed for the presence and location of tumor cells, CEA expression, fluorescence, and radioactivity. Twenty-six of 29 tumor samples obtained from 10 patients contained malignant cells. Overall, fluorescence intensity was higher in tumor areas compared to adjacent non-tumor tissue parts (<i>p</i> < 0.001). The average fluorescence tumor-to-background ratio was 11.8 ± 9.1:1. A similar ratio was found in the autoradiographic analyses. Incubation with a non-specific control antibody confirmed that tumor targeting of our tracer was CEA-specific. Our results demonstrate the feasibility of this tracer for multimodal image-guided surgery. Furthermore, this ex vivo incubation method may help to bridge the gap between preclinical research and clinical application of new agents for radioactive, near infrared fluorescence or multimodal imaging studies.
TMR Design Methodology for SPin-Transfer Torque RAM (SPRAM) with Nonvolatile and SRAM Compatible Operations (2008)

We propose a tunnel magneto resistance (TMR) design methodology for SPRAM that takes into account the disturbances during read operations and the data retention periods. We have clarified that the thermal stability factor (E/k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">B</sub> T) of TMR must be higher than 64 to ensure a 10-year data retention and a continual non-destructive read-operation. Moreover, the thick synthetic ferromagnetic free layer with Fe-rich CoFeB can achieve a E/k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">B</sub> T of 64 while maintaining a low write cell current of less than 400 muA/cell with a 100 times 160 nm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> TMR.
Duration of Electrically Induced Atrial Fibrillation Is Augmented by High Voltage of Stimulus with Higher Blood Pressure in Hypertensive Rats (2014)

Objective. Many previous clinical studies have suggested that atrial fibrillation (AF) is closely associated with hypertension. However, the benefits of antihypertensive therapy on AF are still inconsistent, and it is necessary to explore the factors augmenting AF in hypertensive rats. The aim of the present study was to investigate the correlation between arterial pressure or voltage stimulus and to the duration of electrically induced AF in normotensive or hypertensive rats. Methods. AF was reproducibly induced by transesophageal atrial burst pacing in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). We did the burst pacing at high (20 V) or low (5 V) voltage. Results. Duration of AF did not correlate with systolic blood pressure (SBP) and stimulus voltage in WKY. However, only in SHR, duration of AF with high stimulus voltage significantly correlated with SBP and was significantly longer in high than in low voltage stimulus. Discussion and Conclusion. Duration of AF is augmented by high voltage stimulus with higher blood pressure in SHR.
Shape representation and recognition from curvature (2002)

An approach for describing objects for the purpose of recognition is developed. The authors deal with two key issues: building natural descriptions of curved objects, and making these descriptions compact and abstract. Typical examples of the types of curve one is able to describe as both qualitatively similar, yet discriminably different, are shown. Methods based on curvature extrema alone are likely to find three of the four of these shapes indistinguishable, while methods based on approaches such as shape templates may be oblivious to their similarity. The central ideas of the approach are outlined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Réalisme environnemental des modèles de populations pour l'évaluation de l'impact démographique de la toxicité des contaminants : exemple de la prise en compte de la variabilité saisonnière chez les invertébrés aquatiques (2012)

/ Alors que la population constitue un niveau d'intérêt pour la gestion environnementale (a priori et a posteriori), la caractérisation des effets des contaminants reste difficile directement à ce niveau. En effet, les caractéristiques populationnelles in situ présentent une variabilité naturelle forte, compliquant une lecture spécifique des effets des contaminants. L'expérimentation quant à elle se heurte à la dimension spatiale et temporelle des phénomènes à étudier. Dans les démarches prédictives, la difficulté expérimentale est aujourd'hui contournée par l'emploi de techniques de modélisation permettant le changement d'échelle entre niveaux individuel et populationnel. La paramétrisation de ces modèles de dynamique de populations s'appuie le plus souvent sur des observations de petits groupes d'individus au laboratoire. Néanmoins, le réalisme environnemental de ces modèles doit être amélioré afin de fournir une appréciation pertinente du danger encourue par les populations naturelles. Pour exemple, en couplant encagements in situ, suivis démographiques et modélisation matricielle, nous avons caractérisé la démographie de populations d'invertébrés présents dans nos rivières. Nous montrons ainsi l'importance de prendre en compte la phénologie de ces espèces dans l'extrapolation des effets des contaminants au niveau populationnel. En effet, en recourant à l'analyse de sensibilités de ces modèles, il apparaît grâce à la modélisation que la vulnérabilité démographique des populations face au stress chimique est fortement marquée par une variabilité saisonnière, pouvant remettre fortement en question les conclusions de modèles classiques construits pour appréhender la dynamique de populations au laboratoire.
Structure-Dependent Thermal Defunctionalization of Single-Walled Carbon Nanotubes (2015)

Covalent sidewall functionalization of single-walled carbon nanotubes (SWCNTs) is an important tool for tailoring their properties for research purposes and applications. In this study, SWCNT samples were first functionalized by reductive alkylation using metallic lithium and 1-iodododecane in liquid ammonia. Samples of the alkyl-functionalized SWCNTs were then pyrolyzed under an inert atmosphere at selected temperatures between 100 and 500 °C to remove the addends. The extent of defunctionalization was assessed using a combination of thermogravimetric analysis, Raman measurements of the D, G, and radial breathing bands, absorption spectroscopy of the first- and second-order van Hove peaks, and near-IR fluorescence spectroscopy of (n,m)-specific emission bands. These measurements all indicate a substantial dependence of defunctionalization rate on nanotube diameter, with larger diameter nanotubes showing more facile loss of addends. The effective activation energy for defunctionalization is estimated to be a factor of ∼1.44 greater for 0.76 nm diameter nanotubes as compared to those with 1.24 nm diameter. The experimental findings also reveal the quantitative variation with functionalization density of the Raman D/G intensity ratio and the relative near-IR fluorescence intensity. Pyrolyzed samples show spectroscopic properties that are equivalent to those of SWCNTs prior to functionalization. The strong structure dependence of the defunctionalization rate suggests an approach for scalable diameter sorting of mixed SWCNT samples.
ChemInform Abstract: Design, Synthesis, and Antiproliferative Activity of 3,4‐Diarylpyrazole‐1‐carboxamide Derivatives Against Melanoma Cell Line. (2012)

Abstract The title compounds (III) and (IV) are screened for their antiproliferative activity against the A375 human melanoma cell line.
Multimodal Imaging of Nanovaccine Carriers Targeted to Human Dendritic Cells (2011)

Dendritic cells (DCs) are key players in the initiation of adaptive immune responses and are currently exploited in immunotherapy against cancer and infectious diseases. The targeted delivery of nanovaccine particles (NPs) to DCs in vivo is a promising strategy to enhance immune responses. Here, targeted nanovaccine carriers were generated that allow multimodal imaging of nanocarrier-DC interactions from the subcellular to the organism level. These carriers were made of biodegradable poly(D,L-lactide-co-glycolide) harboring superparamagnetic iron oxide particles (SPIO) and fluorescently labeled antigen in a single particle. Targeted delivery was facilitated by coating the NPs with antibodies recognizing the DC-specific receptor DC-SIGN. The fluorescent label allowed for rapid analysis and quantification of specific versus nonspecific uptake of targeted NPs by DCs compared to other blood cells. In addition, it showed that part of the encapsulated antigen reached the lysosomal compartment of DCs within 24 h. Moreover, the presence of fluorescent label did not prevent the antigen from being presented to antigen-specific T cells. The incorporated SPIO was applied to track the NPs at subcellular cell organel level using transmission electron microscopy (TEM). NPs were found within endolysosomal compartments, where part of the SPIO was already released within 24 h. Furthermore, part of the NPs seemed to localize within the cytoplasm. Ex vivo loading of DCs with NPs resulted in efficient labeling and detection by MRI and did not abolish cell migration within collagen scaffolds. In conclusion, incorporation of two imaging agents within a single carrier allows tracking of targeted nanovaccines on a subcellular, cellular and possibly organism level, thereby facilitating rational design of in vivo targeted vaccination strategies.
ChemInform Abstract: New Reagents for Radical Allylations. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.