gebhart/patrepeval huggingface dataset:
Z skin incision in reduced-port surgery for colorectal cancer (2016)

Laparoscopic surgery for colorectal cancer (CRC) has recently gained in popularity due to the fewer trocars and shorter incision, leading to reduced wound pain and improved cosmetic outcome. In July, 2013, reduced-port surgery (RPS) was introduced and has been performed thereafter in our hospital. An umbilical incision is used for a main port in RPS, through which the specimen is removed and the anastomosis is performed. In order to make the incision shorter, we introduced the Z skin incision in RPS. In this study, we aimed to discuss this method and evaluate the short-term outcome. Among CRC patients undergoing RPS, Z skin incision (n=14) was compared to conventional skin incision (n=15). The clinical and surgical factors were evaluated and there were no significant differences in terms of gender, age, body mass index, tumor site, procedure, operative time, blood loss or complications between the two groups. The median incision length at the umbilicus was significantly shorter in the Z incision group (P=0.004). Particularly in functional end-to-end anastomosis, the median incision length was 2.5 cm in the Z skin incision group and 4.0 cm in the conventional incision group (P=0.018). In conclusion, Z skin incision is a useful technique for achieving an effective length of skin incision in RPS for CRC.
Analysis on the Static Performance of Vacuum-Preloaded Porous Air Bearings (2013)

Air bearings are widely used in precision stages because of low friction and high motion accuracy, however, they suffer from low stiffness in comparison with rolling bearings or hydrostatic bearings. So, several preloading methods using weight, magnet and vacuum force, and opposing pads have been used to increase the stiffness of the air bearings. In this paper, pressure distributions of the vacuum preloaded porous air bearings are calculated using the proposed method. And then, the load capacity and stiffness are analyzed. For the vacuum preloaded air bearings, the stiffness is increased owing to reduced bearing clearance by vacuum force. The simulation results indicate that variation of vacuum pressure with clearance in the vacuum pocket gives rise to low stiffness, so the vacuum pocket should be designed for pressure to be constantly maintained regardless of the bearing clearance by means of large effective pumping speed.
Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin (1996)

Recent studies have indicated that regulatory mechanisms underlying the oxygen-dependent expression of the haematopoietic growth factor erythropoietin are widely operative in non-erythropoietin-producing cells and are involved in the regulation of other genes. An important characteristic of this system is that the inducible response to hypoxia is mimicked by exposure to particular transition metals such as cobaltous ions, and by iron chelation. We have investigated the extent of operation of this system in the regulation of a range of genes concerned with energy metabolism. The effects of hypoxia (1% oxygen), cobaltous ions and desferrioxamine on gene expression in tissue-culture cells was studied using RNase protection assays. Hypoxia induced the expression of glucose transporters in an isoform-specific manner; GLUT-1 and GLUT-3 were induced by hypoxia, whereas expression of GLUT-2 was decreased. Isoenzyme-specific regulation by hypoxia was also observed for genes encoding phosphofructokinase, aldolase and lactate dehydrogenase. For all of these genes, responses to cobaltous ions and desferrioxamine correlated in both direction and magnitude with the response to hypoxia. In contrast, a reduction in mitochondrial transcripts was observed in hypoxia, but these changes were not mimicked by either cobaltous ions or desferrioxamine. These findings indicate that similarities with erythropoietin regulation extend to the oxygen-dependent regulation of genes encoding glucose transporters and glycolytic enzymes but not to the regulation of mitochondrial transcripts, and they show that in glucose metabolism regulation by this system is isoenzyme- or isoform-specific.
Osmotic dehydration of some agro-food tissue pre-treated by pulsed electric field: Impact of impeller’s Reynolds number on mass transfer and color (2012)

Tissues of apple, carrot and banana were pre-treated by pulsed electric field (PEF) and subsequently osmotically dehydrated in an agitated flask at ambient temperature using a 65% sucrose solution as osmotic medium. The effect of stirring intensity was investigated through water loss (WL) and solid gain (SG). Changes in product color were also considered to analyze the impact of the treatment. The impeller’s Reynolds number was used to quantify the agitation. The Reynolds number remained inferior to 300 thus displaying laminar flow regime. Water loss (WL) and solid gain (SG) increase with the increase of Reynolds number. Mass transfer in osmotic dehydration of all three test particles has been studied on the basis of a two-exponential kinetic model. Then, mass transfer coefficients were related to the agitation intensity. This paper shows that the proposed empirical model is able to describe mass transfer phenomena in osmotic dehydration of these tissues. It is also shown that a higher agitation intensity improves both the kinetics of water loss and solid gain.
Automatic Test Generation for Model-Based Code Generators (2006)

This paper presents a novel testing approach for model-based design tools, termed GraphOTK, and applies it to the optimizing component of a code generator for Simulink and Stateflow models.
Estimation of receiver-operating characteristic curves to determine accuracy of a competitive enzyme-linked immunosorbent assay for the serodiagnosis of Brucella infection in domestic water buffalo (Bubalus bubalis) and cattle (2003)

ROC curves can be estimated by use of iterative simulation methods to determine optimal cutoff values for diagnostic tests with quantitative outcomes. A cutoff value of 35% inhibition for the c-ELISA was found to be most appropriate for confirmation of Brucella infection in cattle and water buffalo.
Mobile Computing: Challenges and Potential (1998)

d down versions of desktop operating systems and applications, and Radio Identification Devices (RFID) are providing intelligent communication and computing power with nearly any type of object. This myriad of new devices spans the technological and budgetary spectrums, making it harder to attach the definition of mobile computing to any single device or application. However, there is one underlying similarity among all these devices and applications that allow us to simply define a mobile computer as a computing device which can communicate through a wireless channel. The explosion in mobile computing has been made possible through the continued advancement of certain key technological areas. It is possible to evaluate the past successes, current trends and future opportunities by considering the following areas: First, we need to consider the relationship between mobility, portability, human ergonomics and cost. For example, in order to make a device portable it mus
Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect (2010)

Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of insulin-producing pancreatic beta cells. In both humans and the non-obese diabetic (NOD) mouse model of T1D, class II MHC alleles are the primary determinant of disease susceptibility. However, class I MHC genes also influence risk. These findings are consistent with the requirement for both CD4(+) and CD8(+) T cells in the pathogenesis of T1D. Although a large body of work has permitted the identification of multiple mechanisms to explain the diabetes-protective effect of particular class II MHC alleles, studies examining the protective influence of class I alleles are lacking. Here, we explored this question by performing biochemical and structural analyses of the murine class I MHC molecule H-2K(wm7), which exerts a diabetes-protective effect in NOD mice. We have found that H-2K(wm7) molecules are predominantly occupied by the single self-peptide VNDIFERI, derived from the ubiquitous protein histone H2B. This unexpected finding suggests that the inability of H-2K(wm7) to support T1D development could be due, at least in part, to the failure of peptides from critical beta-cell antigens to adequately compete for binding and be presented to T cells. Predominant presentation of a single peptide would also be expected to influence T-cell selection, potentially leading to a reduced ability to select a diabetogenic CD8(+) T-cell repertoire. The report that one of the predominant peptides bound by T1D-protective HLA-A*31 is histone derived suggests the potential translation of our findings to human diabetes-protective class I MHC molecules.
PCI-27483, a small molecule inhibitor of factor VIIa, inhibits tumor growth in vivo. (2007)

B286 PCI-27483 is a selective small molecule inhibitor of activated coagulation factor VII (FVIIa), which is in preclinical development as a novel anti-cancer agent. Tissue factor (TF), the major initiator of the coagulation cascade, has been shown to be over expressed in numerous primary human tumors, including pancreatic, colon, breast and prostate, and this expression has been linked to disease progression. TF binds to and activates FVII initiating both a proteolytic cascade that leads to coagulation as well as intracellular signaling through the G protein coupled receptor PAR2. Such signaling induces phosphorylation of Akt and MAPK and secretion of vascular endothelial growth factor (VEGF) and the autocrine growth factor IL8, known to stimulate chemotaxis and invasion. Others have shown that the nematode anticoagulant protein (rNAPc2), a TF/FVIIa inhibitor, suppresses the growth of B16F10 melanoma and Lewis lung carcinoma (LLC) cells in murine tumor models (Hembrough et al, Cancer Research 2003). Previous work done in vitro has shown that PCI-27483 inhibits the TF:FVIIa complex induced phosphorylation of Akt and MAPK in BxPC3 cells, a human pancreatic cancer line that highly expresses TF (Holsinger et al, AACR Annual Meeting 2006). In order to more directly examine the role of TF:FVIIa signaling in tumor growth, we tested the efficacy of PCI-27483 in mice implanted with TF expressing tumor cells. In a syngeneic model, subcutaneous administration of PCI-27483 at 22.5 and 45 mg/kg bid to C57BL/6 mice implanted with LLC cells inhibited tumor growth by 45% and 48%, respectively, after 9 days of dosing. In a xenograft model where CD1 nu/nu mice were implanted with HCT-116 (human colorectal carcinoma) cells, subcutaneous administration of PCI-27483 at 90 mg/kg bid, inhibited tumor growth by 65% during the first 11 days of treatment. These data indicate that PCI-27483 has tumor suppression activity in vivo, more so in the LLC syngeneic model than the HCT-116 xenograft model, and suggests that the inhibition of FVIIa has significant therapeutic potential in the treatment of patients with tumors dependent on FVIIa activity for progression.
Thermal Microphotonic Focal Plane Array (TM-FPA) for Uncooled High Sensitivity Thermal Imaging (2007)

We report on a new microphotonic technique for high-sensitivity, uncooled, thermal imaging. The technique, based on the massive thermo-optic effect in thermally isolated microresonators offers potential for significantly higher sensitivity than bolometric techniques.
Role of the Translocation Factor G in the Regulation of Ribonucleic Acid Synthesis (1973)

In an Escherichia coli rel(+)arg strain (ES-2) which carries a temperature-sensitive "G factor," the synthesis of ribonucleic acid (RNA) continues at the nonpermissive temperature (42 C) even though protein synthesis is terminated. However, at 32 C, the strain exhibits a stringent control of RNA synthesis in the absence of arginine. The stringent control of RNA synthesis imposed by trimethoprim (an inhibitor of initiation of protein synthesis) at 32 C is released at the nonpermissive temperature. Even the diauxie lag in RNA synthesis, which is regulated independently of the allelic state of the rel gene, is overcome by inactivation of the G factor. The unusual guanosine nucleotide, guanosine 5'-diphosphate 2' or 3'-diphosphate (ppGpp), is produced in small amounts during growth in strain ES-2. Withdrawal of arginine results in a greater accumulation of this compound at 32 C. At 42 C, the synthesis of ppGpp is abolished and is considerably lower than the level found in ES-2 under normal growth conditions. These results indicate that the translocation factor G plays an important role in the regulation of RNA synthesis and in the synthesis of ppGpp.
Self‐Assembly of Semifluorinated Minidendrons Attached to Electron‐Acceptor Groups into Pyramidal Columns (2007)

The synthesis and self-assembly of twelve semifluorinated first-generation dendrons or minidendrons attached to electron-acceptor (n-type) groups generated from various combinations of eight acceptors and three dendrons are reported. Dendrons attached to small electron-acceptor molecules mediate their self-assembly into pi-stacks located in the center of a supramolecular helical pyramidal column with the long axis of the acceptor perpendicular to the long axis of the column. Dendrons attached to large electron-acceptor molecules, such as perylene bisimide, mediate the assembly of their acceptors in an unprecedented arrangement of pi-stacks that have the long axis of the acceptors parallel to the long axis of the supramolecular pyramidal column. All supramolecular columns self-organize into various periodic columnar arrays that exhibit liquid-crystalline phases, crystalline phases, or a liquid-crystalline phase with enhanced intracolumnar order. The present study demonstrates the simplicity and the versatility of the concept of assembly of n-type electroactive groups mediated by semifluorinated dendrons and assesses the scope and limitations of this supramolecular strategy.
Interaction of p85 subunit of PI 3‐kinase with insulin and IGF‐1 receptors analysed by using the two‐hybrid system (1995)

Interaction of the p85 subunit of PI 3-kinase with the insulin receptor (IR) and the IGF-1 receptor (IGF-1R) was investigated using the two-hybrid system by assessing for his3 and lacZ activation in S. cerevisiae. The experiments were performed with the cytoplasmic beta domain (wild type or mutated) of IR and IGF-1R and p85 or its subdomains (N + C-SH2, N-SH2, C-SH2, SH3 + N-SH2). The results of his3 activation indicated that p85, N + C-SH2 and C-SH2 interact with both IR beta and IGF-1R beta, whereas N-SH2 and SH3 + N-SH2 interact only with IR beta. Interaction of p85 and N+C-SH2 with IR beta (delta C-43) or IGF-1R beta(delta C-43) in which the C-terminal 43 amino acids (including the YXXM motif) were deleted, persisted. The internal binding site thus revealed was not altered by further mutating Y960/F for IR or Y950/F for IGF-1R. Activation of lacZ upon interaction of p85 with IR beta(delta C-43) was 4-fold less as compared to IR beta. This activation with p85 and IGF-1R beta was 4-fold less as compared to IR beta and was somewhat increased (2-fold) for IGF-1R beta (delta C-43). Thus, the C-terminal domain in IGF-1R appears to exert a negative control on binding of p85 thereby providing a possible regulatory mechanism for direct activation of the PI 3-kinase pathway.
Markov chain with small random perturbations with applications to Bacterial Genetics (1996)

Article Markov chain with small random perturbations with applications to Bacterial Genetics was published on January 1, 1996 in the journal Random Operators and Stochastic Equations (volume 4, issue 3).
Development and evaluation of cancer differentiation analysis technology: a novel biophysics-based cancer screening method (2021)

With high specificity and moderate sensitivity of CDA™ test, our study indicates that we can analyze biophysical properties in the blood to rapidly and reliably screen healthy individuals from cancer patients in a health checkup setting where most individuals are healthy or with average risk of cancer.
Total Synthesis and Biological Assessment of Benzimidazole‐Based Analogues of Epothilone A: Ambivalent Effects on Cancer Cell Growth Inhibition (2005)

Benzimidazole-based analogues of cis- and trans-Epo A, 2 and 3, have been prepared through stereoselective total synthesis. Both compounds are highly potent antiproliferative agents, but the effects of side-chain replacement on cellular activity are ambivalent. While significantly enhanced potency is observed against a drug-sensitive human cancer cell line, 2 and 3 more susceptible to P-gp-mediated drug efflux than Epo A or trans-Epo A.
High Valley-Polarization from Interlayer Excitons in van der Waals Heterostructure (2019)

Two-dimensional semiconductors feature valleytronics phenomena due to locking of the spin and momentum valley of the electrons. However, the valley polarization is intrinsically limited in monolayer crystals by the fast intervalley electron-hole exchange. Hetero-bilayer crystals have been shown to have a longer exciton lifetime and valley depolarization time. But the reported valley polarization was low; the valley selection rules and mechanisms of valley depolarization remains controversial. Here, we report singlet and brightened triplet interlayer excitons both with over 80% valley polarizations, cross- and co-polarized with the pump laser, respectively. This is achieved in WSe2/MoSe2 hetero-bilayers with precise momentum valley alignment and narrow emission linewidth. The high valley polarizations allow us to identify the band minima in a hetero-structure and con_rm unambiguously the direct band-gap exciton transition, ultrafast charge separation, strongly suppressed valley depolarization. Our results pave the way for using semiconductor heterobilayers to control valley selection rules for valleytronic applications.
L'immunité antitumorale : des concepts à l'immunothérapie active spécifique. (1999)

L es espoirs de l'immunothrapie spcifique reposent sur l'existence potentielle d'effecteurs d'une rponse antitumorale. Nous dveloppe-rons dans cet article les voies de recherche permettant d'induire cette rponse immunitaire et les ventuelles applications prcliniques et thrapeutiques qui en dcoulent. 939 L'immunit antitumorale : des concepts l'immunothrapie active spcifique Le dveloppement d'une rponse immunitaire naturelle dirige contre les tumeurs in vivo ou induite des fins thrapeutiques repose sur le postulat qu'il existe des structures spcifiques la surface des cellules tumorales (l'antigne tumoral) capables d'tre prsentes de manire efficace aux effecteurs du systme immunitaire (lymphocytes T CD4, CD8 ou natural killer). Les progrs raliss ces dernires annes ont montr que les antignes associs aux tumeurs taient des variations de diffrentes protines du soi. Les cellules dendritiques de l'environnement tumoral jouent un rle fondamental dans la prsentation de ces antignes associs aux tumeurs qui met en jeu une panoplie de cytokines immunostimulantes et de molcules de co-stimulation ncessaires la mise en route et au maintien des effecteurs lymphocytaires. Plus rcemment, un compartiment vsiculaire scrt par les cellules dendritiques, les exosomes, a t mis en vidence. Il contient les diffrentes molcules ncessaires la prsentation de l'antigne et peut interagir distance du site tumoral avec le systme immunitaire. La comprhension de l'ensemble des mcanismes de l'immunit antitumorale devrait permettre le dveloppement de stratgies thrapeutiques efficaces et de comprendre les mcanismes varis dvelopps par les tumeurs pour chapper au systme immunitaire.
Destructive Leaders and Dysfunctional Organizations: A Therapeutic Approach (2009)

Organizational behavior and leadership research has traditionally been deeply influenced by positive psychology and appreciative inquiry. Yet, in recent times, a wave of corporate scandals and spectacular organizational failures has forced management and organizational theorists to rethink this approach. Unethical CEO behavior, white collar crime, property deviance, employee grievances and lawsuits, organizational terrorism, and workplace violence have all provided the impetus for an examination of the darker side of leadership. In Destructive Leaders and Dysfunctional Organizations, Alan Goldman draws on his extensive experience as a management consultant and executive coach to provide a fascinating behind-closed-doors account of troubled leaders and the effect they have on their organizations. Featuring clinical case studies, ranging from the fashion industry to an aeronautical engineering corporation, the book explores the damaging effects of destructive leadership on organizations and provides the tools necessary for early recognition, assessment, and treatment
IBM Scenario Planning Advisor: Plan recognition as AI planning in practice (2019)

We present the IBM Research Scenario Planning Advisor (SPA), a decision support system that allows users to generate diverse alternate scenarios of the future and enhance their ability to imagine the different possible outcomes, including unlikely but potentially impactful futures. Our system, take s as input the relevant information from news and social media, representing key risk drivers, as well as the domain knowledge and generates scenarios that explain the key risk drivers and describe the alternative futures. To this end, we provide a characterization of the problem, knowledge engineering methodology, and transformation to AI planning. Furthermore, we describe the computation of the scenarios, lessons learned, and the feedback received from the pilot deployment of the SPA system in IBM.
Development of a Post-Processing Methodology for Studying Thermal Stratification in an HCCI Engine (2012)

Naturally occurring thermal stratification significantly impacts the characteristics of HCCI combustion. The in-cylinder gas temperature distributions prior to combustion dictate the ignition phasing, burn rates, combustion efficiency, and unburned hydrocarbon and CO emissions associated with HCCI operation. Characterizing the gas temperature fields in an HCCI engine and correlating them to HCCI burn rates is a prerequisite for developing strategies to expand the HCCI operating range. To study the development of thermal stratification in more detail, a new analysis methodology for post-processing experimental HCCI engine data is proposed. This analysis tool uses the autoignition integral in the context of the mass fraction burned curve to infer information about the distribution of temperature that exists in the cylinder prior to combustion. An assumption is made about the shape of the charge temperature profiles of the unburned gas during compression and after combustion starts elsewhere in the cylinder. Secondly, it is assumed that chemical reaction rates proceed very rapidly in comparison to the staggering of ignition phasing from thermal stratification. The autoignition integral is then coupled to the mass fraction burned curve to produce temperature-mass distributions that are representative of a particular combustion event. Due to the computational efficiency associated with this zero-dimensional calculation, a large number of zones can be simulated at very little computational expense. The temperature-mass distributions are then studied over a coolant temperature sweep. The results show that very small changes to compression heat transfer can shift the distribution of mass and temperature in the cylinder enough to significantly affect HCCI burn rates and emissions.