gebhart/patrepeval huggingface dataset:
Comparing the Feasibility and Acceptability of a Virtual Human, Teletherapy, and an e-Manual at Delivering a Stress Management Intervention to Distressed Adult Women: A Pilot Study (Preprint) (2022)

<sec> <title>BACKGROUND</title> Virtual humans (VH), teletherapy, and self-guided e-manuals may increase the accessibility of psychological interventions. However, there is limited research on how these technologies compare in terms of their feasibility and acceptability at delivering stress management interventions. </sec> <sec> <title>OBJECTIVE</title> The objectives of this pilot study were to: (1) conduct a preliminary comparison of the feasibility and acceptability of a VH, teletherapy, and an e-manual at delivering one module of Cognitive Behavioral Stress Management (CBSM) including training in CBT and deep breathing; and (2) evaluate the feasibility of the trial methodology in preparation for future research. </sec> <sec> <title>METHODS</title> A pilot RCT was conducted with a parallel, mixed design. A community sample of adult women who self-identified as distressed were randomly allocated to receive one 90-minute session of CBSM by a VH (VH-CBSM), teletherapy (T-CBSM), or an e-manual (E-CBSM) plus homework over two weeks. Data were collected on feasibility (technical issues, missing data), acceptability (completion, engagement, self-report ratings, qualitative responses), therapist rapport and trust. </sec> <sec> <title>RESULTS</title> 38 participants’ data were included in analyses. A VH (n=12), teletherapy (n=12), and an e-manual (n=14) were found to be feasible and acceptable for delivering one session of CBSM based on the overall data (all ps&gt;.05). Rapport (p&lt;.001) and trust (p=.048) were greater with the human teletherapist than with the VH. However, participants commented favourably on the VH conversational agent perceiving it as non-judgemental and lacking social pressure. Participants were found to have a similar degree of satisfaction and willingness to recommend each technology (ps&gt;.396). There was a non-significant trend towards participants feeling more comfortable with using the VH and e-manual from home compared to teletherapy (p=.097). The methodology was feasible, although improvements were identified for a future trial. </sec> <sec> <title>CONCLUSIONS</title> A VH, teletherapy, and a self-guided e-manual were generally feasible and acceptable methods of delivering one session of a stress management intervention to healthy adult women in distress. Findings support creating additional CBSM modules for delivery by these technologies, and conducting a fully-powered RCT to compare the feasibility, acceptability, and effectiveness of the technologies when delivering a full 10-week stress management programme. </sec> <sec> <title>CLINICALTRIAL</title> Australia New Zealand Clinical Trials Registry (ANZCTR): ACTRN12620000859987 </sec>
Transient Cavitation and Acoustic Emission Produced by Different Laser Lithotripters (1998)

Transient cavitation and shockwave generation produced by pulsed-dye and holmium:YAG laser lithotripters were studied using high-speed photography and acoustic emission measurements. In addition, stone phantoms were used to compare the fragmentation efficiency of various laser and electrohydraulic lithotripters. The pulsed-dye laser, with a wavelength (504 nm) strongly absorbed by most stone materials but not by water, and a short pulse duration of approximately 1 microsec, induces plasma formation on the surface of the target calculi. Subsequently, the rapid expansion of the plasma forms a cavitation bubble, which expands spherically to a maximum size and then collapses violently, leading to strong shockwave generation and microjet impingement, which comprises the primary mechanism for stone fragmentation with short-pulse lasers. In contrast, the holmium laser, with a wavelength (2100 nm) most strongly absorbed by water as well as by all stone materials and a long pulse duration of 250 to 350 microsec, produces an elongated, pear-shaped cavitation bubble at the tip of the optical fiber that forms a vapor channel to conduct the ensuing laser energy to the target stone (Moss effect). The expansion and subsequent collapse of the elongated bubble is asymmetric, resulting in weak shockwave generation and microjet impingement. Thus, stone fragmentation in holmium laser lithotripsy is caused primarily by thermal ablation (drilling effect).
Processing Method for Interpenetrating Network Metal-Ceramic Composites with a Non-Linear Compositional Gradient (2009)

This chapter contains sections titled: Abstract Introduction Experimental Procedure Results and Discussion Conclusion Acknowledgements References
Supplementary Figure 4 from CpG Island Methylator Phenotype–Positive Tumors in the Absence of <i>MLH1</i> Methylation Constitute a Distinct Subset of Duodenal Adenocarcinomas and Are Associated with Poor Prognosis (2023)

&lt;p&gt;PDF file, 545K, Kaplan-Meier survival estimates of time-to-recurrence in 99 patients with duodenal adenocarcinomas by (A) age, (B) stage, (C) differentiation, and (D) chemotherapy and/or radiotherapy.&lt;/p&gt;
Physical Optics versus Gaussian Beam Shooting for shadow field analysis in high frequency regime (2016)

Simulation of high frequency fields using Iterative Physical Optics and Gaussian Beam Shooting algorithms is studied. Particular attention is payed to the field evaluation accuracy in shadow regions. The accuracy is evaluated by comparing the results to those of numerically rigorous numerical methods.
Supplementary Data Set from Array-Based Comparative Genomic Hybridization Analysis Identified Cyclin D1 as a Target Oncogene at 11q13.3 in Nasopharyngeal Carcinoma (2023)

&lt;p&gt;Array CGH data set&lt;/p&gt;
Corpus processing service: A Knowledge Graph platform to perform deep data exploration on corpora (2020)

Abstract Knowledge Graphs have been fast emerging as the de facto standard to model and explore knowledge in weakly structured data. Large corpora of documents constitute a source of weakly structured data of particular interest for both the academic and business world. Key examples include scientific publications, technical reports, manuals, patents, regulations, etc. Such corpora embed many facts that are elementary to critical decision making or enabling new discoveries. In this paper, we present a scalable cloud platform to create and serve Knowledge Graphs, which we named corpus processing service (CPS). Its purpose is to process large document corpora, extract the content and embedded facts, and ultimately represent these in a consistent knowledge graph that can be intuitively queried. To accomplish this, we use state‐of‐the‐art natural language understanding models to extract entities and relationships from documents converted with our previously presented corpus conversion service platform. This pipeline is complemented with a newly developed graph engine which ensures extremely performant graph queries and provides powerful graph analytics capabilities. Both components are tightly integrated and can be easily consumed through REST APIs. Additionally, we provide user interfaces to control the data ingestion flow and formulate queries using a visual programming approach. The CPS platform is designed as a modular microservice system operating on Kubernetes clusters. Finally, we validate the quality of queries on our end‐to‐end knowledge pipeline in a real‐world application in the oil and gas industry.
Negative Refraction in the Optical Range and Left-Handed Photonics (2009)

Abstract : In this project, we were concerned primarily with studying the physical phenomena, devices and designs related to negative refraction in the optical frequency range. We used theoretical work, computer simulations, and experimental studies to further the understanding of negative refraction in the high sought-after optical range. Our work has brought a number of significant advances, including experimental demonstrations of negative refraction well into the visible range to advanced designs in hyperlens and cloaking devices. The physics and repercussions of negative refraction in nonlinear optical systems has also been considered in our work, with the goal of understanding this newly opened and extremely exciting field of optics research.
Role of inflammation in right ventricular damage and repair following experimental pulmonary embolism in rats (2008)

Right ventricular (RV) dysfunction is associated with poor clinical outcome following pulmonary embolism (PE). Previous studies in our laboratory show that influx of neutrophils contributes to acute RV damage seen in an 18 h rat model of PE. The present study describes the further progression of inflammation over 6 weeks and compares the neutrophil and monocyte responses. The RV outflow tract became white in colour by day 1 with influx of neutrophils (tissue myeloperoxidase activity increased 17-fold) and mononuclear cells with characteristics of M1 phenotype (high in Ccl20, Cxcl10, CcR2, MHCII, DNA microarray analysis). Matrix metalloproteinase activities were increased and tissue was thinned to produce a translucent appearance in weeks 1 through 6 in 40% of hearts. RV contractile function was significantly reduced at 6 weeks of PE. In this later phase, there was accumulation of myofibroblasts, the presence of mononuclear cells with M2 characteristics (high in scavenger mannose receptors, macrophage galactose lectin 1, PDGFR1, PDGFRbeta), enrichment of the subendocardial region of the RV outflow tract with neovesels (alpha-smooth muscle immunohistochemistry) and deposition of collagen fibres (picrosirius red staining) beginning scar formation. Thus, while neutrophil response is associated with the early, acute inflammatory events, macrophage cells continue to be present during the proliferative phase and initial deposition of collagen in this model, changing from the M1 to the M2 phenotype. This suggests that the macrophage cell response is biphasic.
An Architecture-Level Energy and Area Estimator for Processing-In-Memory Accelerator Designs (2020)

Processing-in-memory (PIM) deep neural network (DNN) accelerators, which aim to improve energy/area efficiency of DNN processing by integrating computation into data storage, have gained popularity in recent years. Therefore, it is attractive to have a generally applicable framework that is able to quickly provide insights into the various trade-offs involved in PIM accelerator designs. We present an architecture-level design estimation framework for PIM accelerators that allows easy representations of the designs with provided architecture templates and component design templates, performs analytical runtime simulations, and produces technology-dependent area and energy estimations. We show that the framework can be easily used to evaluate state of the art PIM accelerator designs; it achieves 95% accurate total energy estimations and reproduces exact area breakdowns of the components in the design. Related open-source code is available at http://accelergy.mit.edu/.
Taxamycin Studies:  CrCl2/NiCl2-Mediated Cyclizations and Unusual SeO2 Oxidations (1997)

International audience
Association between MRI parameters and the MS severity scale: a 12 year follow-up study (2009)

MRI measures of axonal loss are associated with higher overall disease severity in MS patients.
Laser sintering 2.0: DMDs enable a next generation additive manufacturing technology (2022)

Polymer powder bed additive manufacturing is the most prolific industrial additive manufacturing technology, thanks to Laser Sintering and High Speed Sintering (HSS) technologies. Recent advancements have included adding additional laser systems (with significant costs) and the use of HSS technologies to increase machine throughput. However, polymer powder bed AM technologies are still very limited on processable materials and quality control. Ascend Manufacturing is leveraging high power digital micromirror devices (DMD) to overcome these obstacles and provide a commercial next-generation additive manufacturing solution. This presentation will introduce Ascend Manufacturing's novel Large Area Projection Sintering technology and discuss the additional advantages of area-based processing.
Fine Chemicals from Lignosulfonates. 1. Synthesis of Vanillin by Oxidation of Lignosulfonates (1999)

The oxidation of lignosulfonates (LS) to vanillin by persulphate, oxygen, and a variety of catalytic systems has been investigated. Cobalt and copper catalysts appeared to be the most effective in the oxidation by oxygen. An investigation where multivariate mathematical and statistical design and modelling have been used for the process optimisation has led to the development of a multivariate mathematical model which describes the oxidation process with high predictive capacity. By using this model, an increase of the vanillin yield from 4.1% of the current procedure to 7.2% is obtained, this corresponding to 75% relative improvement of the yield.
Th2-predominant inflammation and blockade of IFN-γ signaling induce aneurysms in allografted aortas (2004)

Abdominal aortic aneurysms (AAAs) cause death due to complications related to expansion and rupture. The underlying mechanisms that drive AAA development remain largely unknown. We recently described evidence for a shift toward T helper type 2 (Th2) cell responses in human AAAs compared with stenotic atheromas. To evaluate putative pathways in AAA formation, we induced Th1- or Th2-predominant cytokine environments in an inflammatory aortic lesion using murine aortic transplantation into WT hosts or those lacking the receptors for the hallmark Th1 cytokine IFN-gamma, respectively. Allografts in WT recipients developed intimal hyperplasia, whereas allografts in IFN-gamma receptor-deficient (GRKO) hosts developed severe AAA formation associated with markedly increased levels of MMP-9 and MMP-12. Allografts in GRKO recipients treated with anti-IL-4 antibody to block the characteristic IL-4 Th2 cytokine or allografts in GRKO hosts also congenitally deficient in IL-4 did not develop AAA and likewise exhibited attenuated collagenolytic and elastolytic activities. These observations demonstrate an important dichotomy between cellular immune responses that induce IFN-gamma- or IL-4-dominated cytokine environments. The findings establish important regulatory roles for a Th1/Th2 cytokine balance in modulating matrix remodeling and have important implications for the pathophysiology of AAAs and arteriosclerosis.
ChemInform Abstract: An Efficient Synthesis of Tetrasubstituted Imidazoles from N‐(2‐Oxo)‐amides. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Study of the Effect of Hole Clearance and Thread Fit on the Self-Loosening of Threaded Fasteners (2006)

This study provides an experimental and theoretical investigation of the effect of hole clearance and thread fit on the self-loosening of tightened threaded fasteners that are subjected to a cyclic transverse service load. An experimental procedure and test set up are developed in order to collect real-time data on the rate of clamp load loss per cycle as well as the loosening rotation of the bolt head. Three levels of hole clearance are investigated; namely, 3%, 6%, and 10% of the bolt nominal diameter. For the commonly used 2A thread fit for a selected bolt size, three classes of the nut thread fit are considered; namely, 1B, 2B, and 3B. A simplified mathematical model is used for the analytical investigation of the effect of the hole clearance and thread fit on threaded fasteners self-loosening. The experimental and theoretical results are presented and discussed.
Cooperative End-to-End and Lateral Hydrogen-Bonding Motifs in Supramolecular Thermoplastic Elastomers (2006)

Communication to the Editor
Registration of intracellular pH in cancer cells with genetically encoded ratiometric sensor (2015)

This work is aimed at the development of new approach to register intracellular pH with genetically encoded ratiometric sensor. Intracellular pH of cancer cells was studied <i>in vitro </i>and <i>in vivo</i>. Changes of intracellular pH under conditions of co-culturing with fibroblast were investigated.
Mutli-layered neutron detector (2023)

A neutron detector including a plurality of layers of converter material and a plurality of layers of detector material. Each layer of converter material can be immediately adjacent to at least one layer of detector material and each layer of detector material can be immediately adjacent to at least one layer of converter material. The neutron detector may further include a read out integrated circuit (ROIC) that is electrically coupled to the plurality of layers of detector material. A value output by the ROIC may be indicative of a neutron interacting with a layer of converter material from amongst the plurality of layers of converter material.
The sigma subunit of Escherichia coli RNA polymerase senses promoter spacing. (1996)

The promoters recognized by sigma 70, the primary sigma of Escherichia coli, consist of two highly conserved hexamers located at -10 and -35 bp from the start point of transcription, separated by a preferred spacing of 17 bp. sigma factors have two distinct DNA binding domains that recognize the two hexamer sequences. However, the component of RNA polymerase recognizing the length of the spacing between hexamers has not been determined. Using an equilibrium DNA binding competition assay, we demonstrate that a polypeptide of sigma 70 carrying both DNA binding domains is very sensitive to promoter spacing, whereas a sigma 70 polypeptide with only one DNA binding domain is not. Furthermore, a mutant sigma, selected for increasing transcription of the minimal lac promoter (18-bp spacer), has an altered response to promoter spacing in vivo and in vitro. Our data support the idea that sigma makes simultaneous, productive contacts at both the -10 and the -35 regions of the promoter and discerns the spacing between these conserved regions.
Alkyl Monolayers on Silica Surfaces Prepared from Neat, Heated ClSi(CH3)2(CH2)17CH3 Analyzed by XPS (2001)

Silane monolayers on silica, prepared from mono-, di- and trichlorosilanes, are widely used in industry for surface functionalization and modification. However, unlike di- and trichlorosilanes, monochlorosilanes are particularly easy to work with because they can dimerize, but not polymerize, upon reaction with water. Typically, an organic solvent is used when depositing a silane monolayer. Here we show XPS spectra of monolayers of ClSi(CH3)2(CH2)17CH3 (octadecyldimethylchlorosilane, CAS# 18643-08-8) on silicon oxide (silicon wafer) prepared using a rapid, solvent-free approach. Reaction conditions are 120 °C for 10 min using the neat (pure) compound, and no inert atmosphere or special treatment of the compound is required.
Initial Experience With Laparoscopic Transvesical Ureteral Reimplantation at the Children’s Hospital of Philadelphia (2006)

Laparoscopic intravesical reimplantation is in its infancy and appears to have higher complication rates in young patients with small bladder capacity.
Intracellular Delivery of Oligonucleotides with Cationic Liposomes (2017)

This chapter discusses the use of cationic liposomes to facilitate delivery of antisense oligonucleotides to cells. Cationic lipids were originally synthesized as general drug delivery vehicles which would interact with the negative charge on the cell surface. P.L. Felgner demonstrated that liposomes prepared from the synthetic cationic lipid, N-[1-(2,3-dioleyloxy)propyl]-N,N,N,-trimethylammoniurn chloride, and dioleoyl phosphatidylethanolamine facilitated the intracellular delivery of DNA and RNA to cultured cells. Optimal activity of cationic liposomes was observed at an equal molar ratio of positive charge from the cationic lipid and negative charge from the oligonucleotide. The cationic lipid used in the study were synthesized with ester bonds linking the hydrophobic moiety to the cationic moiety, which was postulated to be more readily metabolized in biological assay systems than ether linkages. At oligonucleotide concentrations sufficient to neutralize the surface charge of the cationic liposomes the charge repulsion of the lipid vesicles would be eliminated, allowing the vesicles to fuse, entrapping the oligonucleotide in the process.
Synthesis and preliminary evaluation of an iodovinyl‐tetrabenazine analog as a marker for the vesicular monoamine transporter (1993)

Abstract A derivative of tetrabenazine (TBZ, 1 ) containing an iodovinyl group (I‐TBZ, 3b ) was prepared as a potential radiotracer for the vesicular monoamine transporter. The synthesis of 3a was achieved by ethynylation of TBZ. The ethynyl derivative 4 , was converted to the corresponding vinylstannane 5 . The vinylstannane intermediate was then treated with I 2 in chloroform at room temperature, to afford the iodovinyl compound ( 3a , I‐TBZ). The no‐carrier‐added [ 125 I]I‐TBZ ( 3b ) was prepared by treating an ethanolic solution of 5 with sodium[ 125 I]iodide in the presence of H 2 O 2 . Following i.v. injection, [ 125 I]I‐TBZ ( 3b ) can readily cross the blood brain barrier and localize in the brain (0.92 and 0.36% dose/organ, at 2 min and 30 min, respectively). However, no specific regional uptake of the ligand was observed. Subsequent biodistribution studies performed using two well resolved peaks obtained from chiral HPLC separation of 3b , demonstrated that Fraction I displayed higher brain uptake (0.6% dose/organ, 20 min) than the latter peak (Fraction II , 0.3% dose/organ, 20 min). Fraction I also exhibited a modest degree of specificity for the striatum which could be blocked by pretreatment with tetrabenazine. The high lipophilicity of 3a (P o/b for Fraction 1 and II =1723 and 1395, respectively) may contribute to high nonspecific binding in vivo, and result in the low target/nontarget ratio observed for this compound. Iodovinyl‐TBZ analog 3b is a poor candidate as a SPECT imaging agent for the vesicular monoamine transporter.
Extraction of Protein-Bound ATP and ADP from Human Platelets in Plasma (1990)

Actin is the major ATP and ADP binding protein in platelets, 0.9-1.3 nmol/10(8) cells, 50-70% in the unpolymerized state. The goal of these experiments was to develop a method for extracting all protein-bound ATP and ADP from undisturbed platelets in plasma. Extraction of actin-bound ADP is routine while extraction of actin-bound ATP from platelets in buffer has been unsuccessful. Prior to extraction the platelets were exposed to 14-C adenine, to label the metabolic and actin pools of ATP and ADP. The specific activity was determined from the actin-bound ADP in the 43% ethanol precipitate. Sequential ethanol and perchlorate extractions of platelet rich plasma, and the derived supernatants and precipitates were performed. ATP concentrations were determined with the luciferase assay, and radioactive nucleotides separated by TLC. A total of 1.18 nmol/10(8) cells of protein-bound ATP and ADP was recovered, 52% ATP (0.61 nmol). The recovery of protein-bound ADP was increased from 0.3 to 0.57 nmol/10(8) cells. This approach for the first time successfully recovered protein bound ATP and ADP from platelets in a concentration expected for actin.