gebhart/patrepeval huggingface dataset:
Epigenetic inactivation of secreted Frizzled‐related proteins in acute myeloid leukaemia (2008)

The Wnt signalling pathway has a key function in stem cell maintenance and differentiation of haematopoietic progenitors. Secreted Frizzled-related protein genes (SFRPs), functioning as Wnt signalling antagonists, have been found to be downregulated by promoter hypermethylation in many tumours. To analyse epigenetic dysregulation of SFRPs in acute myeloid leukaemia (AML), we examined the promoter methylation status of SFRP1, -2, -4 and -5 in AML cell lines by methylation-specific polymerase chain reaction (MSP). Aberrant CpG island methylation was found for all four SFRP genes. By real-time reverse transcription-PCR, corresponding transcriptional silencing for SFRP1 and -2 was demonstrated and treatment of cell lines with 5-aza-2'-deoxycytidine resulted in re-expression. The methylation status of the SFRP genes was analysed in 100 specimens obtained from AML patients at diagnosis. The frequencies of aberrant methylation among the patient samples were 29% for SFRP1, 19% for SFRP2, 0% for SFRP4 and 9% for SFRP5. For SFRP2, a correlation between promoter hypermethylation and transcriptional downregulation was found in primary AML samples. Among AML cases with a favourable karyotype, hypermethylation of SFRP genes was restricted to patients with core binding factor (CBF) leukaemia, and aberrant methylation of the SFRP2 promoter was an adverse risk factor for survival in CBF leukaemia.
Supplementary Figure Legends 1-9 from HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That Is Critical for Tumorigenesis (2023)

Supplementary Figure Legends 1-9 from HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That Is Critical for Tumorigenesis
Poly(L-lactide)-Degrading Enzyme from Laceyella sacchari LP175: Cloning, Sequencing, Expression, Characterization and Its Hydrolysis of Poly(L-lactide) Polymer (2019)

In this study, the poly-(L-lactide) (PLLA)-degrading enzyme from the thermophilic filamentous bacterium, Laceyella sacchari LP175 was characterized for application in biological recycling process. The gene encoding the PLLA-degrading gene (plla_lp175) was cloned and expressed in Escherichia coli. The native protein comprises 383 amino acids with a molecular mass and pI of 39.45 kDa and 8.26, respectively. The recombinant protein was purified by one-step purification, and was found to have a molecular weight of 28 kDa. Functional expression of PLLA_LP175 in E. coli with a pMAL-c5X vector enhanced the expression of PLLA-degrading enzyme up to 756 U/mg of protein, which is a 2.3-fold increase compared to the native strain. The purified recombinant protein is active in the range of pH 7.0-9.0 and 45-60 degrees C, with optimum activity at pH 9.0 and 60 degrees C. The recombinant enzyme could hydrolyse PLLA objects to a different extent depending on PLLA composition, at pH 9.0 and 50 degrees C within 24 h. Monomeric lactic acid was detected as the product from enzymatic degradation of PLLA objects. A scanning electron micrograph, showing a rough surface with holes of all PLLA objects after treatments with the recombinant enzyme, confirmed the ability of this enzyme to degrade PLLA objects.
Synthesis and characterization of the heterometallic phosphinidene clusters (C5Me5)WRu3(CO)10(.mu.3-H)(.mu.3-PPh), (C5H5)WRu2(CO)8(.mu.-H)(.mu.3-PPh), and (C5Me5)WRu2(CO)8(.mu.-H)(.mu.3-PPh) (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of the heterometallic phosphinidene clusters (C5Me5)WRu3(CO)10(.mu.3-H)(.mu.3-PPh), (C5H5)WRu2(CO)8(.mu.-H)(.mu.3-PPh), and (C5Me5)WRu2(CO)8(.mu.-H)(.mu.3-PPh)Ren Chiun Lin, Yun Chi, Shie Ming Peng, and Gene Hsiang LeeCite this: Inorg. Chem. 1992, 31, 18, 3818–3824Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/ic00044a026https://doi.org/10.1021/ic00044a026research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Analysis of the Reactive CO2 Surface Flux in Electrocatalytic Aqueous Flow Reactors (2021)

We study how the mass transfer of a chemical species in shear flow is suppressed by the production of a second species that partially reacts away the first species. The second species is produced at the surface with the first species as a reactant. Our work is directly motivated by electrochemical CO2 reduction in aqueous flow reactors, where OH– molecules generated by the CO evolution reaction react away CO2 molecules, ultimately inhibiting the mass transfer of CO2 to the cathode surface. We derive a simple approximation of the Sherwood number, a dimensionless measure of the mass flux into the surface, as a function of the Péclet number, surface Damköhler number, and bulk Damköhler number, and we compare our approximation to numerical solutions of the governing equations. We find that in the diffusion-limited regime, the Sherwood number is well described by the classical Graetz-Lévêque result reduced by a reaction factor due to the competing bulk reaction; with the stoichiometry relevant to electrochemical CO2 reduction, this reaction factor is 1/2. While the model problem we solve provides insight into how OH– production affects CO2 mass transfer, experimental systems often involve more complex chemistry. We thus also show how a common buffered electrolyte, KHCO3, affects our results.
Survey of Bandgap and Non-bandgap based Voltage Reference Techniques (2016)

The design challenges of voltage reference generators in CMOS technology have increased over the years in low voltage low power CMOS integrated circuits constituting analog, digital and mixed-signal modules. The emergence of hand-held power autonomous devices push the power consumption limit to nW regime. Along with these confrontations, limited full scale range of data converters at low supply levels demands accurate reference voltage generators. This paper reviews the allied design challenges and discusses the evolved methodologies to tackle them. This paper also prominently retrospect the sub -1V voltage reference topologies presented in the literature along with classic bandgap based voltage reference topologies. Non- bandgap (only CMOS) based reference architectures are proven to be area and power efficient but always have to be accompanied with auxiliary on/off chip trimming mechanism for high accuracy. We also provide insightful analysis of the voltage reference topologies, required by the designers.
Development of a coupled CH structure for the GSI proton injector (2007)

The FAIR facility, under development at GSI, needs a new dedicated proton injector for the production of intense secondary <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</i> macr beams. This injector will accelerate protons from 3 to 70 MeV at a current of 70 mA, and due to the high voltage gain and shunt impedance will be based on CH cavities powered by 6 2.5 MW, 325 MHz klystrons. An innovative coupling cell containing one drift tube of length <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Nbetalambda</i> was developed to combine multicell drift tube modules of the CH-type ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">211</sub> mode). In order to study this coupling mechanism a 1:2 scaled model of the second resonator of GSI proton injector was fabricated at IAP and it ready for testing. The according full scale prototype, a 3 meter long coupled resonator from 11.7 MeV to 24.1 MeV is under development and will be power tested with a 2.5 MW klystron at GSI early in 2009. This paper describes in detail the coupled structure together with a general overview of the R&D results achieved on the CH-DTL's cavity.
Using Nature's polyenes as templates: studies of synthetic xanthomonadin analogues and realising their potential as antioxidants (2019)

Two truncated analogues of the polyenyl photoprotective xanthomonadin pigments have been synthesised utilising an iterative Heck-Mizoroki (HM)/iododeboronation cross coupling approach and investigated as models of the natural product photoprotective agents in bacteria. Despite the instability of these types of compounds, both analogues proved to be sufficiently stable to allow isolation, spectroscopic analysis and biological studies of their photoprotective behaviour which showed that despite their shorter polyene chain length, they retained the ability to protect bacteria from photochemical damage; i.e. incorporation of one compound into E. coli provided photoprotective activity against singlet oxygen analogous to the natural photoprotective mechanisms employed by Xanthomonas bacteria, answering key questions about what minimal functionality is required to impart photoprotection, potentially leading to new classes of photoprotective and antioxidants compounds.
Identification of oncostatin M as a JAK2 V617F‐dependent amplifier of cytokine production and bone marrow remodeling in myeloproliferative neoplasms (2011)

The JAK2 mutation V617F is detectable in a majority of patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs). Enforced expression of JAK2 V617F in mice induces myeloproliferation and bone marrow (BM) fibrosis, suggesting a causal role for the JAK2 mutant in the pathogenesis of MPNs. However, little is known about mechanisms and effector molecules contributing to JAK2 V617F-induced myeloproliferation and fibrosis. We show that JAK2 V617F promotes expression of oncostatin M (OSM) in neoplastic myeloid cells. Correspondingly, OSM mRNA levels were increased in the BM of patients with MPNs (median 287% of ABL, range 22-1450%) compared to control patients (median 59% of ABL, range 12-264%; P < 0.0001). OSM secreted by JAK2 V617F+ cells stimulated growth of fibroblasts and microvascular endothelial cells and induced the production of angiogenic and profibrogenic cytokines (HGF, VEGF, and SDF-1) in BM fibroblasts. All effects of MPN cell-derived OSM were blocked by a neutralizing anti-OSM antibody, whereas the production of OSM in MPN cells was suppressed by a pharmacologic JAK2 inhibitor or RNAi-mediated knockdown of JAK2. In summary, JAK2 V617F-mediated up-regulation of OSM may contribute to fibrosis, neoangiogenesis, and the cytokine storm observed in MPNs, suggesting that OSM might serve as a novel therapeutic target molecule in these neoplasms.
Current Advances of Tubulin Inhibitors in Nanoparticle Drug Delivery and Vascular Disruption/Angiogenesis (2016)

Extensive research over the last decade has resulted in a number of highly potent tubulin polymerization inhibitors acting either as microtubule stabilizing agents (MSAs) or microtubule destabilizing agents (MDAs). These inhibitors have potent cytotoxicity against a broad spectrum of human tumor cell lines. In addition to cytotoxicity, a number of these tubulin inhibitors have exhibited abilities to inhibit formation of new blood vessels as well as disrupt existing blood vessels. Tubulin inhibitors as a vascular disrupting agents (VDAs), mainly from the MDA family, induce rapid tumor vessel occlusion and massive tumor necrosis. Thus, tubulin inhibitors have become increasingly popular in the field of tumor vasculature. However, their pharmaceutical application is halted by a number of limitations including poor solubility and toxicity. Thus, recently, there has been considerable interests in the nanoparticle drug delivery of tubulin inhibitors to circumvent those limitations. This article reviews recent advances in nanoparticle based drug delivery for tubulin inhibitors as well as their tumor vasculature disruption properties.
The Effect of Si on the Precipitates for Nb Bearing High Purity Ferritic Stainless Steel (2011)

The effect of Si on the precipitation of the Laves phase in high purity 17Cr–0.5Nb ferritic stainless steel was investigated. Precipitation was observed using a scanning electron microscope and transmission electron microscope. Quantitative analysis of the amount of precipitates as Laves phase was performed. The precipitation rate of the Laves phase and the equilibrium amount of precipitates of the Laves phase increased with the amount of Si. A Si peak was detected in the Laves phase in 0.5Si steel by energy dispersive X-ray spectrometer analysis. It was revealed that precipitation of the Laves phase was promoted and the chemical composition of the Laves phase was changed by the addition of Si.
Transcervical Ultrasonography Is Feasible to Visualize and Evaluate Base of Tongue Cancers (2014)

Ultrasonography can be used to transcervically visualize BOT tumors and provides clinically relevant characteristics that may not otherwise be appreciable.
Abstract 13269: The Tyrosine Kinase Inhibitor Nilotinib Induces Vascular Adverse Events in Patients With Chronic Myeloid Leukemia and Inhibits Endothelial Function and Angiogenesis (2013)

The second-generation BCR/ABL tyrosine kinase inhibitor nilotinib (nilo) is used for treatment of patients (pts) with chronic myeloid leukemia. Nilo has been considered a well-tolerated drug howeve...
Dynamic response to hydration in a superabsorbing polymer studied by carbon-13 NOE and spin-lattice relaxation times (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDynamic response to hydration in a superabsorbing polymer studied by carbon-13 NOE and spin-lattice relaxation timesS. Ganapathy, M. V. Badiger, P. R. Rajamohanan, and R. A. MashelkarCite this: Macromolecules 1992, 25, 17, 4255–4263Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://doi.org/10.1021/ma00043a004RIGHTS & PERMISSIONSArticle Views69Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (975 KB) Get e-Alerts Get e-Alerts
Deep Learning Advances on Different 3D Data Representations: A Survey. (2018)

3D data is a valuable asset the computer vision filed as it provides rich information about the full geometry of sensed objects and scenes. Recently, with the availability of both large 3D datasets and computational power, it is today possible to consider applying deep learning to learn specific tasks on 3D data such as segmentation, recognition and correspondence. Depending on the considered 3D data representation, different challenges may be foreseen in using existent deep learning architectures. In this work, we provide a comprehensive overview about various 3D data representations highlighting the difference between Euclidean and non-Euclidean ones. We also discuss how Deep Learning methods are applied on each representation, analyzing the challenges to overcome.
A Uniquely Accessible Route to the Diastereoselective Synthesis of Azetine Derivatives. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Mining crowd mobility and WiFi hotspots on a densely-populated campus (2017)

Understanding crowd activities at large-scale and diagnosing existing problems of planning on densely-populated campus are fundamentally hard through traditional ways of measurement and management. In this paper, we demonstrate how to collect data from ubiquitous WiFi networks (WLAN), and further to characterize the mobility of campus residents by exploring time-frequency patterns with spatial context. On the campus of Tsinghua University (where everyday nearly 60, 000 mobile devices appear in the public areas of more than 110 buildings), we obtain large-scale observations on physical activities, and provide insights for better diagnosing of WiFi hotspots.
Cu Alloy Metallization for Self-Forming Barrier Process (2006)

A novel Cu-Mn alloy has been developed to self-form a diffusion barrier layer at metal/dielectric interface without depositing a conventional metal barrier layer. The integration results are reviewed first to show its excellent reliability and electrical characteristics. Selection criteria of the alloying element are delineated. The reason why Mn is better than other elements is explained in terms of thermodynamic activity. The impacts of the self-forming barrier process on the BEOL process are discussed
Organic Photodetectors and their Application in Large Area and Flexible Image Sensors: The Role of Dark Current (2019)

Abstract Organic photodetectors (OPDs) have gained increasing interest as they offer cost‐effective fabrication methods using low temperature processes, making them particularly attractive for large area image detectors on lightweight flexible plastic substrates. Moreover, their photophysical and optoelectronic properties can be tuned both at a material and device level. Visible‐light OPDs are proposed for use in indirect‐conversion X‐ray detectors, fingerprint scanners, and intelligent surfaces for gesture recognition. Near‐infrared OPDs find applications in biomedical imaging and optical communications. For most applications, minimizing the OPD dark current density ( J d ) is crucial to improve important figures of merits such as the signal‐to‐noise ratio, the linear dynamic range, and the specific detectivity ( D *). Here, a quantitative analysis of the intrinsic dark current processes shows that charge injection from the electrodes is the dominant contribution to J d in OPDs. J d reduction is typically addressed by fine‐tuning the active layer energetics and stratification or by using charge blocking layers. Yet, most experimental J d values are higher than the calculated intrinsic limit. Possible reasons for this deviation are discussed, including extrinsic defects in the photoactive layer and the presence of trap states. This provides the reader with guidelines to improve the OPD performances in view of imaging applications.
Electro-enzymatic hydroxylation of ethylbenzene by the evolved unspecific peroxygenase of Agrocybe aegerita B Enzymatic (2016)

The unspecific peroxygenase from the fungus Agrocybe aegerita (AaeUPO) is an up-and-coming biocatalyst that is able to perform specific oxyfunctionalizations of various substrates. Due to inactivation at excess concentrations of its co-substrate H2O2, AaeUPO’s technical application is still limited. This study aims to promote catalyst efficiency via electrochemical in situ supply of H2O2, using an evolved variant of AaeUPO on the example of ethylbenzene hydroxylation. Total turnover numbers of up to 400,000molproductmolAaeUPO⁻¹ and space-time-yields of up to 25gL⁻¹d⁻¹ were achieved in the electro-enzymatic system. These numbers are in the upper range of published data. The presented system stands out by its very high atom economy. Thus, combining electrochemistry and biocatalysis is one step closer towards the first application of peroxygenases in an industrial process.
Application of deep learning-based super-resolution to T1-weighted postcontrast gradient echo imaging of the chest (2023)

The application of a novel deep learning-based super-resolution approach in T1-weighted VIBE postcontrast imaging resulted in an improvement in image quality, noise levels and diagnostic confidence as well as in a shortened acquisition time.
Correction: In-Depth Analysis of the Antibody Response of Individuals Exposed to Primary Dengue Virus Infection (2021)

Humans who experience a primary dengue virus (DENV) infection develop antibodies that preferentially neutralize the homologous serotype responsible for infection. Affected individuals also generate cross-reactive antibodies against heterologous DENV serotypes, which are non-neutralizing. Dengue cross-reactive, non-neutralizing antibodies can enhance infection of Fc receptor bearing cells and, potentially, exacerbate disease. The actual binding sites of human antibody on the DENV particle are not well defined. We characterized the specificity and neutralization potency of polyclonal serum antibodies and memory B-cell derived monoclonal antibodies (hMAbs) from 2 individuals exposed to primary DENV infections. Most DENV-specific hMAbs were serotype cross-reactive and weakly neutralizing. Moreover, many hMAbs bound to the viral pre-membrane protein and other sites on the virus that were not preserved when the viral envelope protein was produced as a soluble, recombinant antigen (rE protein). Nonetheless, by modifying the screening procedure to detect rare antibodies that bound to rE, we were able to isolate and map human antibodies that strongly neutralized the homologous serotype of DENV. Our MAbs results indicate that, in these two individuals exposed to primary DENV infections, a small fraction of the total antibody response was responsible for virus neutralization.
A highly efficient 3D micromixer fabricated by standard soft-lithography equipement (2012)

This paper reports a stereolithography-like 3D fabrication method based on soft-lithography techniques. It only requires standard equipment for photolithography, but it makes true 3D structures fabrication possible. We developed a rotating partition by this method in a microfluidic channel, which cannot be achieved by conventional soft-lithography, and demonstrated a prototyping three-dimensional flow mixer.