gebhart/patrepeval huggingface dataset:
Stress Control of Deep Rift Intrusion at Mauna Loa Volcano, Hawaii (2007)

Mauna Loa volcano, Hawaii, deforms by a combination of shallow dike intrusions in the rift zones and earthquakes along the base of the volcano, but it is not known how the spreading is accommodated in the lower part of the volcanic edifice. We present evidence from interferometric synthetic aperture radar data for secular inflation of a dike-like magma body at intermediate depth in the southwest rift zone during 2002 to 2005. Magma accumulation occurred in a section of the rift zone that was unclamped by previous dikes and earthquakes, suggesting that stress transfer plays an important role in controlling subsurface magma accumulation.
Développement et évaluation d'un détecteur à scintillateur pour les petits faisceaux de radiothérapie (2021)

International audience
Kinetic and Structural Characterization of Manganese(II)-Loaded Methionyl Aminopeptidases (2002)

Manganese(II) activation of the methionyl aminopeptidases from Escherichia coli (EcMetAP-I) and the hyperthermophilic archaeon Pyrococcus furiosus (PfMetAP-II) was investigated. Maximum catalytic activity for both enzymes was obtained with 1 equiv of Mn(II), and the dissociation constants (K(d)) for the first metal binding site were found to be 6 +/- 0.5 and 1 +/- 0.5 microM for EcMetAP-I and PfMetAP-II, respectively. These K(d) values were verified by isothermal titration calorimetry (ITC) and found to be 3.0 +/- 0.2 and 1.4 +/- 0.2 microM for EcMetAP-I and PfMetAP-II, respectively. The hydrolysis of MGMM was measured in triplicate between 25 and 85 degrees C at eight substrate concentrations ranging from 2 to 20 mM for PfMetAP-II. Both specific activity and K(m) values increased with increasing temperature. An Arrhenius plot was constructed from the kcat values and was found to be linear over the temperature range 25-85 degrees C. The activation energy for the Mn(II)-loaded PfMetAP-II hydrolysis of MGMM was found to be 25.7 kJ/mol while the remaining thermodynamic parameters calculated at 25 degrees C are DeltaG+ = 50.1 kJ/mol, DeltaH+ = 23.2 kJ/mol, and DeltaS++ = -90.2 J x mol(-1) x K(-1).
Hoe 694, a new Na+/H+ exchange inhibitor and its effects in cardiac ischaemia (1993)

1. The benzoylguanidine derivative Hoe 694 ((3-methylsulphonyl-4- piperidino-benzoyl) guanidine methanesulphonate) was characterized as an inhibitor of Na+/H+ exchange in rabbit erythrocytes, rat platelets and bovine endothelial cells. The potency of the compound was slightly lower or comparable to ethylisopropyl amiloride (EIPA). 2. To investigate a possible cardioprotective role of the Na+/H+ exchange inhibitor Hoe 694, rat isolated working hearts were subjected to ischaemia and reperfusion. In these experiments all untreated hearts suffered ventricular fibrillation on reperfusion. Addition of 10(-7) M Hoe 694 to the perfusate almost abolished reperfusion arrhythmias in the rat isolated working hearts. 3. Hoe 694 reduced the release of lactate dehydrogenase (LDH) and creatine kinase (CK), which are indicators of cellular damage during ischaemia, into the venous effluent of the hearts by 60% and 54%, respectively. 4. The tissue content of glycogen at the end of the experiments was increased by 60% and the high energy phosphates ATP and creatine phosphate were increased by 240% and 270% respectively in the treated hearts as compared to control hearts. 5. Antiischaemic effects of the Na+/H+ exchange inhibitor, Hoe 694, were investigated in a second experiment in anaesthetized rats undergoing coronary artery ligation. In these animals, pretreatment with Hoe 694 caused a dose-dependent reduction of ventricular premature beats and ventricular tachycardia as well as a complete suppression of ventricular fibrillation down to doses of 0.1 mg kg-1, i.v. Blood pressure and heart rate remained unchanged. 6. We conclude that the new Na+/H+ exchange inhibitor, Hoe 694, shows cardioprotective and antiarrhythmic effects in ischaemia and reperfusion in rat isolated hearts and in anaesthetized rats. In view of the role which Na+/H+ exchange seems to play in the pathophysiology of cardiac ischaemia these effects could probably be attributed to Na+/H+ exchange inhibition.
Multiple source multiple destination topology inference using network coding (2009)

Abstract — In this paper, we combine network coding and tomographic techniques for topology inference. Our goal is to infer the topology of a network by sending probes between a given set of multiple sources and multiple receivers and by having intermediate nodes perform network coding operations. We combine and extend two ideas that have been developed independently. On one hand, network coding introduces topology-dependent correlation, which can then be exploited at the receivers to infer the topology [1]. On the other hand, it has been shown that a traditional (i.e., without network coding) multiple source, multiple receiver tomography problem can be decomposed into multiple two source, two receiver subproblems [2]. Our first contribution is to show that, when intermediate nodes perform network coding, topological information contained in network coded packets allows to accurately distinguish among all different 2-by-2 subnetwork components, which was not possible with traditional tomographic techniques. Our second contribution is to use this knowledge to merge the subnetworks and accurately reconstruct the general topology. Our approach is applicable to any general Internet-like topology, and is robust to the presence of delay variability and packet loss. I.
Single-dose AAV vector gene immunotherapy to treat food allergy (2022)

Immunotherapies for patients with food allergy have shown some success in limiting allergic responses. However, these approaches require lengthy protocols with repeated allergen dosing and patients can relapse following discontinuation of treatment. The purpose of this study was to test if a single dose of an adeno-associated virus (AAV) vector can safely prevent and treat egg allergy in a mouse model. AAV vectors expressing ovalbumin (OVA) under an ubiquitous or liver-specific promoter were injected prior to or after epicutaneous sensitization with OVA. Mice treated with either AAV8-OVA vector were completely protected from allergy sensitization. These animals had a significant reduction in anaphylaxis mediated by a reduction in OVA-specific IgE titers. In mice with established OVA allergy, allergic responses were mitigated only in mice treated with an AAV8-OVA vector expressing OVA from an ubiquitous promoter. In conclusion, an AAV vector with a liver-specific promoter was more effective for allergy prevention, but higher OVA levels were necessary for reducing symptoms in preexisting allergy. Overall, our AAV gene immunotherapy resulted in an expansion of OVA-specific FoxP3<sup>+</sup> CD4<sup>+</sup> T cells, an increase in the regulatory cytokine IL-10, and a reduction in the IgE promoting cytokine IL-13.
Group-orthogonal multi-carrier CDMA (2003)

Code division multiple access (CDMA) over frequency-selective fading channels faces challenges in suppressing multiuser interference (MUI), but can also benefit from the channel-induced multipath diversity. On the other hand, uncoded orthogonal frequency division multiple access (OFDMA) is MUI-free by design, but faces challenges arising from the fading-induced loss of multipath diversity. We wed the advantages of CDMA with those of OFDMA. We design a group-orthogonal multi-carrier CDMA (GO-MC-CDMA) scheme that minimizes MUI subject to the constraint that the full multipath diversity is enabled for all users. Each group of GO-MC-CDMA users shares a properly selected set of system subcarriers. MUI only exists among users in the same small-size group, which renders the application of low-complexity multiuser detection per group practically feasible. Simulation results illustrate the merits of GO-MC-CDMA over competing multi-access alternatives.
Examination of the differential impacts of antitachycardia pacing vs. shock on patient activity in the EMPIRIC study (2015)

This study is the first to evaluate objective, behavioural effects of shock, and whether these effects are comparable with ATP therapy alone. In tandem with existing literature, current results highlight that ICD shocks and ATP have divergent effects on behavioural outcomes, with ATP's effect profile in these domains appearing somewhat favourable.
The prediction of impedance using quasi-static field theory (2002)

It is demonstrated that the impedance of practical electromagnetic devices can be accurately predicted from first principles using quasi-static time-harmonic field theory. A general method for computing the impedance of electromagnetic devices is discussed. The method entails a two-step approach in which a field solution is obtained (assuming steady-state operation) and then used to compute a lumped-parameter equivalent circuit. The field solution is computed using finite element analysis. The method is demonstrated using a simple device consisting of a loop of copper wire fixed below an aluminum plate. Impedance values are computed for a frequency range of 100 kHz to 1 MHz and compared with measured data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Materials, Figure Legends 1-6 from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer (2023)

Supplementary Materials, Figure Legends 1-6 from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
Epidémiologie des adénomes hypophysaires (2007)

Les adénomes hypophysaires représentent une pathologie fréquente parmi les tumeurs cérébrales. Une étude liègoise récente a montré une prévalence des adénomes hypophysaires cliniquement actifs de 1:1064 habitants, nettement supérieure aux données antérieures. Tant dans les séries cliniques qu'autopsiques, les microadénomes à prolactine sont les adénomes prédominants. Les adénomes hypophysaires sont le plus souvent de présentation sporadique, mais des adénomes familiaux dans des formes isolées ou syndromiques sont également décrits. Les adénomes hypophysaires familiaux représentent 5 p.100 des adénomes hypophysaires et leur caractérisation clinique et génétique a été récemment enrichie par la description de la nouvelle entité FIPA (Familial Isolated Pituitary Adenomas) et des mutations du gène AIP (Aryl hydrocarbon receptor-Interactircg Protein). Bien que d'évolution habituellement bénigne, les adénomes hypophysaires sont caractérisés par une grande diversité clinique et génétique qui réclame des moyens diagnostiques et thérapeutiques spécifiques.
Simulation of cogging in a 100 kW permanent magnet octagonal linear generator for ocean wave conversion (2005)

Fluctuations in the torque acting on the rotor in a rotating electric generator i.e., cogging, gives unstable rotor motion and can venture reliable operation of the machine. Cogging also gives a similar fluctuation in the output power. This work presents a study of the cogging force in a linear permanent magnet generator. A constant output power is possible in a rotating machine with three phases winding. In a linear generator, due to the reciprocate piston motion, power fluctuations on the slow time scale of the piston bounce period cannot be avoided. Associated with power variations on a time scale shorter than the piston bounce motion is fluctuations on the force (torque) acting on the piston, i.e., cogging. Cogging is not less dangerous in linear generators compared to rotation machines and the problem requires investigation. The paper investigates means to reduce cogging by improving the geometrical design of the stator. In particular, rational number of the slots per pole and phase reduce the cogging by one order of magnitude.
Ultrasensitive Detection of Cymbidium Mosaic Potexvirus Using a Single-Wall Carbon Nanotube-Functionalized Quartz Crystal Microbalance (2010)

We have developed an ultrasensitive, convenient, real-time platform for detecting Cymbidium mosaic potexvirus (CymMV) based on single-wall carbon nanotube (SWNT)-functionalized quartz crystal microbalance (QCM) sensors. Functionalization was achieved by coating the QCM electrode with SWNTs, followed by 1,1'-carbonyldiimidazole-activated Tween 20 (CDI–Tween 20) modification and conjugation of antibodies. Sensitivity was enhanced from 2.18 to 11.5 Hz ng -1 when 0.1 µg mL -1 CymMV was applied. The low limit of detection of SWNT-functionalized QCM sensors was improved from 2.08 to 0.502 ng. The SWNT-functionalized QCM sensor was successfully used to quantify the amount of CymMV contained in infected orchid leaves. Compared to enzyme-linked immunosorbent assay (ELISA), SWNT-functionalized QCM sensors are fast, economical, and ultra-sensitive, with comparable sensitivities. The current study demonstrates the application of QCM sensors as a convenient platform to detect and quantify CymMV.
Analysis of surface generation in the ultraprecision polishing of freeform surfaces (2009)

The use of freeform designs in engineering surfaces has become increasingly popular over the last decade. Applications of freeform shapes range from aesthetics of components to the bending of light rays through advanced optic designs. The fabrication of the components for these applications requires submicrometre form accuracy, in some cases with surface roughness at nanometric levels. Ultraprecision polishing is an emerging technology for the fabrication of high-precision and high-quality freeform surfaces. However, the factors affecting nanosurface generation in ultraprecision polishing have received relatively little attention. Moreover, the quality of the polished surface relies heavily on appropriate selection of process conditions and polishing strategies. This paper presents an analytical study of the factors affecting surface generation in ultraprecision polishing. A series of polishing experiments have been designed and undertaken, allowing the relationships between various factors and the surface quality of the workpiece to be determined. The results of the study provide a better understanding of nanosurface generation, as well as the strategy for optimizing surface quality, in the ultraprecision polishing of freeform surfaces.
ChemInform Abstract: Steric and Electronic Control of Iron Porphyrin Catalyzed Hydrocarbon Oxidations. (1986)

Abstract The yields and product distributions in the oxidation of hydrocarbons (cyclohexane, n‐pentane, n‐octane, methylcyclohexane, tert.‐butylcyclohexane, ethylben‐ ′ zene) using substituted iron tetraphenylporphyrins (I), iron phthalocyanine, iron perfluorophthalocyanine and iodosobenzene, are shown to be markedly affected by the nature and location of phenyl ring substituents.
Comparison of radiographical imaging modalities for measuring the diameter of renal masses: is there a sizeable difference? (2011)

•All three standard renal imaging modalities appear to accurately predict pathological tumour size. •These data are relevant to the interpretation and comparison of treatment strategies, such as active surveillance protocols and ablative therapy, where pathological size is not available. •Furthermore, lack of inferiority of ultrasonography in predicting pathological tumour size affords opportunities for the reduction of patient radiation exposure and for cost containment.
CT Findings After Nephron-Sparing Surgery of Renal Tumors (2007)

Familiarity with the various postoperative changes after nephron-sparing surgery may help radiologists in differentiating these changes from tumor recurrence or surgical complications.
Gene Encoding a Trehalose Phosphorylase fromThermoanaerobacter brockiiATCC 35047 (2002)

A gene encoding a trehalose phosphorylase was cloned from Thermoanaerobacter brockii ATCC 35047. The gene encodes a polypeptide of 774 amino acid residues. The deduced amino acid sequence was homologous to bacterial maltose phosphorylases and a trehalose 6-phosphate phosphorylase catalyzing anomer-inverting reactions. On the other hand, no homology was found between the T. brockii enzyme and an anomer-retaining trehalose phosphorylase from Grifola frondosa.
Role of leukotriene B4 in bronchial hyperresponsiveness induced by interleukin-8 (1998)

Repeated intranasal administration of interleukin 8 (IL-8) induces bronchial hyperresponsiveness (BHR) accompanied by lower airway neutrophil accumulation (ANA) in guinea-pigs. Leukotriene B4 (LTB4) is a chemotactic factor for neutrophils. To elucidate whether LTB4 and neutrophil elastase are involved in the IL-8-induced BHR and ANA, the effects of a LTB4 antagonist (ONO-4057) and a neutrophil elastase inhibitor (ONO-5046) on the responses were examined. IL-8 (5 microg x kg[-1]) was administered intranasally to guinea-pigs twice weekly for 3 weeks. One day after the last administration, animals were anaesthetized and artificially ventilated through tracheal cannulae, and lateral pressure at the tracheal cannula (Pao) was measured as an overall index of airway responses to inhaled histamine. ONO-4057 (2 or 20 mg x kg[-1]) or ONO-5046 (30 or 300 mg x kg[-1]) was administered intraperitoneally 24 and 1 h before anaesthesia. ONO-4057, but not ONO-5046, significantly inhibited the IL8-induced BHR and ANA, assessed by bronchoalveolar lavage, in a dose-dependent manner. These findings suggest that interleukin 8 causes bronchial hyperresponsiveness and airway neutrophil accumulation in guinea-pigs in vivo. In part this appears to be due to release of leukotriene B4, whereas it may not be mediated by neutrophil elastase.
CCDC 1446329: Experimental Crystal Structure Determination (2004)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Novel SAMD9 Mutation in a Patient With Immunodeficiency, Neutropenia, Impaired Anti-CMV Response, and Severe Gastrointestinal Involvement (2019)

Mutations in the Sterile alpha motif domain containing 9 (<i>SAMD9</i>) gene have been described in patients with severe multisystem disorder, MIRAGE syndrome, but also in patients with bone marrow (BM) failure in the absence of other systemic symptoms. The role of hematopoietic stem cell transplantation (HSCT) in the management of the disease is still unclear. Here, we present a patient with a novel mutation in <i>SAMD9</i> (c.2471 G>A, p.R824Q), manifesting with prominent gastrointestinal tract involvement and immunodeficiency, but without any sign of adrenal insufficiency typical for MIRAGE syndrome. He suffered from severe CMV (cytomegalovirus) infection at 3 months of age, with a delayed development of T lymphocyte functional response against CMV, profound T cell activation, significantly reduced B lymphocyte counts and impaired lymphocyte proliferative response. Cultured T cells displayed slightly lower calcium flux and decreased survival. At the age of 6 months, he developed severe neutropenia requiring G-CSF administration, and despite only mild morphological and immunophenotypical disturbances in the BM, 78% of the BM cells showed monosomy 7 at the age of 18 months. Surprisingly, T cell proliferation after CD3 stimulation and apoptosis of the cells normalized during the follow-up, possibly reflecting the gradual development of monosomy 7. Among other prominent symptoms, he had difficulty swallowing, requiring percutaneous endoscopic gastrostomy (PEG), frequent gastrointestinal infections, and perianal erosions. He suffered from repeated infections and periodic recurring fevers with the elevation of inflammatory markers. At 26 months of age, he underwent HSCT that significantly improved hematological and immunological laboratory parameters. Nevertheless, he continued to suffer from other conditions, and subsequently, he died at day 440 post-transplant due to sepsis. Pathogenicity of this novel <i>SAMD9</i> mutation was confirmed experimentally. Expression of mutant <i>SAMD9</i> caused a significant decrease in proliferation and increase in cell death of the transfected cells. <b>Conclusion:</b> We describe a novel <i>SAMD9</i> mutation in a patient with prominent gastrointestinal and immunological symptoms but without adrenal hypoplasia. Thus, SAMD9 mutations should be considered as cause of enteropathy in pediatric patients. The insufficient therapeutic outcome of transplantation further questions the role of HSCT in the management of patients with <i>SAMD9</i> mutations and multisystem involvement.
Continuous Flow Synthesis of α-Trifluoromethylthiolated Esters and Amides from Carboxylic Acids: a Telescoped Approach (2021)

A continuous flow approach to access α-trifluoromethylthiolated esters and amides using commercially available arylacetic acids and <i>N</i>-(trifluoromethylthio)phthalimide as the electrophilic reagent is described. The experimental protocol involves the in-flow conversion of the carboxylic acid into <i>N-</i>acylpyrazole followed by the α-trifluoromethylthiolation in a PTFE coil reactor and final reaction with primary or secondary amines, or alcohols, to afford in a telescoped process α-substituted SCF<sub>3</sub> amides and esters, respectively, in good overall yield and short reaction times.
Supplementary Figure 5 from ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment (2023)

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Proteoglycan 4 Reduces Neuroinflammation and Protects the Blood–Brain Barrier after Traumatic Brain Injury (2020)

Neuroinflammation and dysfunction of the blood-brain barrier (BBB) are two prominent mechanisms of secondary injury in neurotrauma. It has been suggested that Toll-like receptors (TLRs) play important roles in initiating and propagating neuroinflammation resulting from traumatic brain injury (TBI), but potential beneficial effects of targeting these receptors in TBI have not been broadly studied. Here, we investigated the effect of targeting TLRs with proteoglycan 4 (PRG4) on post-traumatic neuroinflammation and BBB function. PRG4 is a mucinous glycoprotein with strong anti-inflammatory properties, exerting its biological effects by interfering with TLR2/4 signaling. In addition, PRG4 has the ability to inhibit activation of cluster of differentiation 44 (CD44), a cell-surface glycoprotein playing an important role in inflammation. Using the controlled cortical impact model of TBI in rats, we showed a rapid and prolonged upregulation of message for TLR2/4 and CD44 in the injured cortex. In the <i>in vitro</i> model of the BBB, recombinant human PRG4 (rhPRG4) crossed the endothelial monolayers through a high-capacity, saturable transport system. In rats sustaining TBI, PRG4 delivery to the brain was enhanced by post-traumatic increase in BBB permeability. rhPRG4 injected intravenously at 1 h post-TBI potently inhibited post-traumatic activation of nuclear factor kappa B and extracellular signal-regulated kinases 1/2, the two major signal transduction pathways associated with TLR2/4 and CD44, and curtailed the post-traumatic influx of monocytes. In addition, PRG4 restored normal BBB function after TBI by preventing the post-traumatic loss of tight junction protein claudin 5 and reduced neuronal death. Our observations provide support for therapeutic strategies targeting TLRs in TBI.