gebhart/patrepeval huggingface dataset:
The Impact Of Prior Exposure To Rituximab On Autologous Stem Cell Transplantation In Patients With Follicular And Transformed Lymphoma (2010)

Introduction: Addition of rituximab to chemotherapy (CT) for follicular lymphoma (FL) has been shown to improve many outcome parameters. Often, high-dose therapy is followed by autologous stem-cell transplantation (ASCT) after 1, 2 or more relapses. Kang et al. (BMT (2007) 40, 973) investigated whether prior exposure to rituximab had any influence on a subsequent ASCT and found no differences in the outcomes analyzed. However, there has been evidence suggesting that that such prior exposure may alter the phenotype of these tumour cells so that they no longer express CD20, and thus potentially altering their behaviour. Methods: We performed a retrospective review on all patients having received an ASCT at the Ottawa Hospital with an initial diagnosis of FL. They were grouped into four categories according to their prior exposure to or lack of prior exposure to rituximab and according to their pre-ASCT diagnosis, non-transformed FL (FL-NT) vs. transformed (FL-T). Results: 259 patients who underwent an autoHSCT for FL were divided into 4 groups: 184 FL non-transformed (FL-NT) (31 patients received rituximab and 153 did not), and 75 FL-transformed (FL-T) (24 patients received rituximab and 51 did not). The 5-year progression-free survivals (PFS) were 61.2% and 27.6%, respectively (p<0.0001) and the overall survivals (OS) were 72.5% and 39.3%, respectively, (p<0.0001). In the FL-NT group, no differences existed in PFS or OS between FL-NT rituximab-naïve and rituximab-treated patients (5-year PFS 61% vs. 64%, p=0.69; 5-year OS 73% vs. 68%, p=0.80). Within the FL-T group, the subsequent 5-year PFS of the rituximab-naive vs. pre-treated groups were 22% and 55% (p =0.20), respectively, and the 5-year OS were 36% and 51% (p=0.39), respectively. Prior exposure to R had a positive effect (Hazard Ratio (HR): 0.44, 95% CI 0.20-0.97, p=0.04) on PFS and OS (HR: 0.5, 95% CI 0.21-1.18, p=0.11). Pre-treatment with rituximab in FL-NT prior to ASCT does not adversely impact ASCT outcomes. There is a suggestion of an increase in the number of patients with FL-T being transplanted in the post-rituximab era and as expected, the FL-T had a poorer outcome than the FL-NT patients. However, prior exposure to rituximab appeared to demonstrate a trend toward an improved OS within the FL-T group. In summary, previous rituximab exposure may be associated with an increased rate of transformation, leading to the poorer outcome of patients originally diagnosed with FL-NT.
Understanding the Rocksalt-to-Wurtzite phase transformation through microstructural analysis of (Al,Sc)N epitaxial thin films (2016)

Rocksalt-to-wurtzite structural phase transitions in semiconducting materials (such as III–V nitrides, ZnO, CdSe, and others) have been studied for several decades. Almost all experimental works related to this phase transition involve diamond anvil cells to apply hydrostatic pressure, and as a result, direct observation of the microstructural transformation during the phase transition has not been possible. In this article, we have addressed and uncovered the intimate microstructural details and epitaxial relationships between phases by capturing what is essentially a thin-film snapshot of the transformation after growth of AlxSc1-xN films with a composition chosen to be close to the equilibrium phase boundary between wurtzite and rocksalt. The results support the hypothesis that the transformation is triggered by defects at rs-{01¯1} growth fronts that offer a nearly invariant plane with respect to the parallel w-{21¯1¯0} planes. The intermediate crystal structures and their epitaxial relationships are consistent with theoretical models that predict a transformation pathway involving homogeneous orthorhombic shear strain.
Emerging energy and environmental applications of vertically-oriented graphenes (2015)

Graphene nanosheets arranged perpendicularly to the substrate surface, i.e., vertically-oriented graphenes (VGs), have many unique morphological and structural features that can lead to exciting properties. Plasma-enhanced chemical vapor deposition enables the growth of VGs on various substrates using gas, liquid, or solid precursors. Compared with conventional randomly-oriented graphenes, VGs' vertical orientation on the substrate, non-agglomerated morphology, controlled inter-sheet connectivity, as well as sharp and exposed edges make them very promising for a variety of applications. The focus of this tutorial review is on plasma-enabled simple yet efficient synthesis of VGs and their properties that lead to emerging energy and environmental applications, ranging from energy storage, energy conversion, sensing, to green corona discharges for pollution control.
Photoacoustic imaging with an acoustic lens detects prostate cancer cells labeled with PSMA-targeting near-infrared dye-conjugates (2016)

There is an urgent need for sensitive and specific tools to accurately image early stage, organ-confined human prostate cancers to facilitate active surveillance and reduce unnecessary treatment. Recently, we developed an acoustic lens that enhances the sensitivity of photoacoustic imaging. Here, we report the use of this device in conjunction with two molecular imaging agents that specifically target the prostate-specific membrane antigen (PSMA) expressed on the tumor cell surface of most prostate cancers. We demonstrate successful imaging of phantoms containing cancer cells labeled with either of two different PSMA-targeting agents, the ribonucleic acid aptamer A10-3.2 and a urea-based peptidomimetic inhibitor, each linked to the near-infrared dye IRDye800CW. By specifically targeting cells with these agents linked to a dye chosen for optimal signal, we are able to discriminate prostate cancer cells that express PSMA.
Clinical Validation of a Structural Porous Tantalum Biomaterial for Adult Reconstruction (2004)

Bobyn, J. Dennis PhD; Poggie, R.A. PhD; Krygier, J.J. CET; Lewallen, D.G. MD; Hanssen, A.D. MD; Lewis, R.J. MD; Unger, A.S. MD; O'Keefe, T.J. MD; Christie, M.J. MD; Nasser, S. MD; Wood, J.E. MD; Stulberg, S.D. MD; Tanzer, M. MD Author Information
Catalytic Transformation of Carbon Black to Carbon Nanotubes (2002)

We report here a novel method of catalytic transformation of amorphous carbon to CNT. The method involves Fe(CO)5 thermolysis in the presence of carbon black at high pressure. A mechanism is proposed; it is verified by solid-state NMR measurements.
Emerging Type‐II Superlattices of InAs/InAsSb and InAs/GaSb for Mid‐Wavelength Infrared Photodetectors (2021)

Mid‐wavelength infrared (MWIR) photodetectors (PDs) are highly essential for environmental sensing of hazardous gases, security, defense, and medical applications. Mercury cadmium telluride (MCT) materials have been the most used detector in the MWIR range. However, it is plagued by several challenges including toxicity concerns, a high rate of Auger nonradiative recombination, a large band‐to‐band (BTB) tunneling current, nonuniformity, and the need for cryogenic cooling. Theoretically, it is predicted that type‐II superlattice (T2SL) materials can emerge as an alternative with the potential to outperform the current state‐of‐the‐art MCT PDs due to suppression of Auger recombination associated with bandgap engineering and reduced BTB tunneling current caused by the larger effective mass. Based on this theoretical prediction, it is believed that T2SL have the potential to operate at high temperatures and overcome the size, weight, and power consumption limitations of MCT. Herein, a detailed review of the fundamental material properties of T2SL PDs is provided while providing a comparison of the optical and electrical performances of Ga‐free (InAs/InAsSb) and Ga‐based (InAs/GaSb) T2SL PDs. Finally, recent advances in IR detection technologies including focal plane arrays and quantum cascade infrared photodetectors are explored.
Echo-planar MR determination of relative cerebral blood volume in human brain tumors: T1 versus T2 weighting. (1996)

Although the T1 rCBV maps showed less contrast as compared with the T2 rCBV maps, they provided diagnostic information that was comparable to the T2 rCBV maps in our series of 19 patients with primary brain tumors.
An Optimal Torque Vectoring Control for Vehicle Applications via Real-Time Constraints (2015)

A generalized integrated control strategy for vehicle dynamics using an optimal torque vectoring control approach is extended in this paper. The central objective of this approach is to generate optimal additional tire forces and yaw moment over the vehicle through the application of individual wheel torque to keep the vehicle on a target path. This is achieved by minimizing the error between the actual and target forces and moment at the center of gravity (CG). In this paper, this methodology is extended to a constrained optimal control approach that handles additional real-time constraints, which has several vehicle control applications. An online optimization strategy is used to solve the resulting constrained optimization problem that gives the necessary tire force adjustments at the tire level. Some typical applications are 1) differential braking on all wheels, which is applicable to both electric and conventional cars and 2) hybrid torque vectoring on the front wheels and differential braking on the rear wheels. Both simulations and experimental results show the usefulness of this approach of handling constraints with this optimal torque vectoring control.
Highly Oxygenated Decalins via Michael-Claisen Condensation (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHighly Oxygenated Decalins via Michael-Claisen CondensationOswy Z. Pereira and T. H. ChanCite this: J. Org. Chem. 1994, 59, 22, 6710–6716Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/jo00101a033https://doi.org/10.1021/jo00101a033research-articleACS PublicationsRequest reuse permissionsArticle Views696Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A ±4A high-side current sensor with 25V input CM range and 0.9% gain error from −40°C to 85°C using an analog temperature compensation technique (2018)

This paper presents a fully integrated ±4A current sensor that supports a 25V input common-mode voltage range (CMVR) while operating from a single 1.5V supply. It consists of an on-chip metal shunt, a beyond-the-rails ADC [1] and a temperature-dependent voltage reference. The beyond-the-rails ADC facilitates high-side current sensing without the need for external resistive dividers or level shifters, thus reducing power consumption and system complexity. To compensate for the shunt's temperature dependence, the ADC employs a proportional-to-absolute-temperature (PTAT) reference voltage. Compared to digital temperature compensation schemes [2,3], this analog scheme eliminates the need for a temperature sensor, a band-gap voltage reference and calibration logic. As a result, the current sensor draws only 10.9μA and is 10x more energy efficient than [2]. Over a ±4A range, and after a one-point trim, the sensor exhibits a 0.9% (max) gain error from -40°C to 85°C and a 0.05% gain error at room temperature. The former is comparable with that of other fully-integrated current sensors [2-4], while the latter represents the state-of-the-art.
Supplementary Methods from Superior Efficacy of a Combined Epigenetic Therapy against Human Mantle Cell Lymphoma Cells (2023)

&lt;p&gt;PDF file, 19K.&lt;/p&gt;
ChemInform Abstract: The Direct Decomposition of NO over the La2CuO4 Nanofiber Catalyst. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Generation and Characterization of an Attenuated Mutant in a Response Regulator Gene of Francisella tularensis Live Vaccine Strain (LVS) (2008)

Francisella tularensis is a zoonotic bacterium that must exist in diverse environments ranging from arthropod vectors to mammalian hosts. To better understand how virulence genes are regulated in these different environments, a transcriptional response regulator gene (genome locus FTL0552) was deleted in F. tularensis live vaccine strain (LVS). The FTL0552 deletion mutant exhibited slightly reduced rates of extracellular growth but was unable to replicate or survive in mouse macrophages and was avirulent in the mouse model using either BALB/c or C57BL/6 mice. Mice infected with the FTL0552 mutant produced reduced levels of inflammatory cytokines, exhibited reduced histopathology, and cleared the bacteria quicker than mice infected with LVS. Mice that survived infection with the FTL0552 mutant were afforded partial protection when challenged with a lethal dose of the virulent SchuS4 strain (4 of 10 survivors, day 21 postinfection) when compared to naive mice (0 of 10 survivors by day 7 postinfection). Microarray experiments indicate that 148 genes are regulated by FTL0552. Most of the genes are downregulated, indicating that FTL0552 controls transcription of genes in a positive manner. Genes regulated by FTL0552 include genes located within the Francisella pathogenicity island that are essential for intracellular survival and virulence of F. tularensis. Further, a mutant in FTL0552 or the comparable locus in SchuS4 (FTT1557c) may be an alternative candidate vaccine for tularemia.
Actinic characterization of extreme ultraviolet bump-type phase defects (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Kenneth A. Goldberg, Iacopo Mochi; Actinic characterization of extreme ultraviolet bump-type phase defects. J. Vac. Sci. Technol. B 1 November 2011; 29 (6): 06F502. https://doi.org/10.1116/1.3653257 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science & Technology B Search Advanced Search |Citation Search
Amortized Probabilistic Detection of Communities in Graphs (2020)

Learning community structures in graphs has broad applications across scientific domains. While graph neural networks (GNNs) have been successful in encoding graph structures, existing GNN-based methods for community detection are limited by requiring knowledge of the number of communities in advance, in addition to lacking a proper probabilistic formulation to handle uncertainty. We propose a simple framework for amortized community detection, which addresses both of these issues by combining the expressive power of GNNs with recent methods for amortized clustering. Our models consist of a graph representation backbone that extracts structural information and an amortized clustering network that naturally handles variable numbers of clusters. Both components combine into well-defined models of the posterior distribution of graph communities and are jointly optimized given labeled graphs. At inference time, the models yield parallel samples from the posterior of community labels, quantifying uncertainty in a principled way. We evaluate several models from our framework on synthetic and real datasets, and demonstrate improved performance compared to previous methods. As a separate contribution, we extend recent amortized probabilistic clustering architectures by adding attention modules, which yield further improvements on community detection tasks.
Supplementary Figure 2 from Antitumor Activity of the Hsp90 Inhibitor IPI-504 in HER2-Positive Trastuzumab-Resistant Breast Cancer (2023)

Supplementary Figure 2 from Antitumor Activity of the Hsp90 Inhibitor IPI-504 in HER2-Positive Trastuzumab-Resistant Breast Cancer
Reversing statistics for scalable test databases generation (2013)

Testing the performance of database systems is commonly accomplished using synthetic data and workload generators such as TPC-H and TPC-DS. Customer data and workloads are hard to obtain due to their sensitive nature and prohibitively large sizes. As a result, oftentimes the data management systems are not properly tested before releasing, and performance-related bugs are commonly discovered after deployment, when the cost of fixing is very high. In this paper we propose RSGen, an approach to generating datasets out of customer metadata information, including schema, integrity constraints and statistics. RSGen enables generation of data that closely matches the customer environment, and is fast, scalable and extensible.
Rer1p competes with APH-1 for binding to nicastrin and regulates γ-secretase complex assembly in the early secretory pathway (2007)

The gamma-secretase complex, consisting of presenilin, nicastrin, presenilin enhancer-2 (PEN-2), and anterior pharynx defective-1 (APH-1) cleaves type I integral membrane proteins like amyloid precursor protein and Notch in a process of regulated intramembrane proteolysis. The regulatory mechanisms governing the multistep assembly of this "proteasome of the membrane" are unknown. We characterize a new interaction partner of nicastrin, the retrieval receptor Rer1p. Rer1p binds preferentially immature nicastrin via polar residues within its transmembrane domain that are also critical for interaction with APH-1. Absence of APH-1 substantially increased binding of nicastrin to Rer1p, demonstrating the competitive nature of these interactions. Moreover, Rer1p expression levels control the formation of gamma-secretase subcomplexes and, concomitantly, total cellular gamma-secretase activity. We identify Rer1p as a novel limiting factor that negatively regulates gamma-secretase complex assembly by competing with APH-1 during active recycling between the endoplasmic reticulum (ER) and Golgi. We conclude that total cellular gamma-secretase activity is restrained by a secondary ER control system that provides a potential therapeutic value.
Reduction of on-resistance and current crowding in quasi-vertical GaN power diodes (2017)

This paper studies the key parameters affecting on-resistance and current crowding in quasi-vertical GaN power devices by experiment and simulation. The current distribution in the drift region, n−-GaN, was found to be mainly determined by the sheet resistance of the current spreading layer, n+-GaN. The actual on-resistance of the drift region significantly depends on this current distribution rather than the intrinsic resistivity of the drift layer. As a result, the total specific on-resistance of quasi-vertical diodes shows a strong correlation with the device area and sheet resistance of the current spreading layer. By reducing the sheet resistance of the current spreading layer, the specific on-resistance of quasi-vertical GaN-on-Si power diodes has been reduced from ∼10 mΩ·cm2 to below 1 mΩ·cm2. Design space of the specific on-resistance at different breakdown voltage levels has also been revealed in optimized quasi-vertical GaN power diodes.
Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer (2015)

Resistance to therapy and lack of curative treatments for metastatic breast cancer suggest that current therapies may be missing the subpopulation of chemoresistant and radioresistant cancer stem cells (CSC). The ultimate success of any treatment may well rest on CSC eradication, but specific anti-CSC therapies are still limited. A comparison of the transcriptional profiles of murine Her2(+) breast tumor TUBO cells and their derived CSC-enriched tumorspheres has identified xCT, the functional subunit of the cystine/glutamate antiporter system xc(-), as a surface protein that is upregulated specifically in tumorspheres. We validated this finding by cytofluorimetric analysis and immunofluorescence in TUBO-derived tumorspheres and in a panel of mouse and human triple negative breast cancer cell-derived tumorspheres. We further show that downregulation of xCT impaired tumorsphere generation and altered CSC intracellular redox balance in vitro, suggesting that xCT plays a functional role in CSC biology. DNA vaccination based immunotargeting of xCT in mice challenged with syngeneic tumorsphere-derived cells delayed established subcutaneous tumor growth and strongly impaired pulmonary metastasis formation by generating anti-xCT antibodies able to alter CSC self-renewal and redox balance. Finally, anti-xCT vaccination increased CSC chemosensitivity to doxorubicin in vivo, indicating that xCT immunotargeting may be an effective adjuvant to chemotherapy.
Poly(vinylpyridine) Segments in Block Copolymers: Synthesis, Self-Assembly, and Versatility (2019)

This Perspective provides a current survey on the synthesis, self-assembly, and vast variety of applications possible from block copolymer (BCP) systems containing at least one segment of either poly(2-vinylpyridine), P2VP, or poly(4-vinylpyridine), P4VP. Strategies and insight toward P2VP or P4VP as the segment of choice and their influence on material properties, effective interaction parameters, and hosting a variety chemistries from small molecules to nanoparticles are provided. It is with hope that this work serves as a modern field guide to the versatility and utility of these chemistries for those new to or continuing research with these BCP systems.
Superconducting TiN through-silicon-vias for quantum technology (2019)

Through-silicon vias (TSVs) can be used to route signals and to obtain effective grounding in microwave circuits. The coating of the TSVs with a superconducting material is a challenge because of the high aspect ratio of the structures. In this paper, we present successful fabrication of superconducting 60 μm diameter TSVs, coated by atomic layer deposition (ALD) of titanium nitride. The critical temperature T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> is approximately 1.6 K.