gebhart/patrepeval huggingface dataset:
Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury (2023)

Neutrophil extracellular traps (NETs) are abundant in sepsis, and proposed NET-directed therapies in sepsis prevent their formation or accelerate degradation. Yet NETs are important for microbial entrapment, as NET digestion liberates pathogens and NET degradation products (NDPs) that deleteriously promote thrombosis and endothelial cell injury. We proposed an alternative strategy of NET-stabilization with the chemokine, platelet factor 4 (PF4, CXCL4), which we have shown enhances NET-mediated microbial entrapment. We now show that NET compaction by PF4 reduces their thrombogenicity. In vitro, we quantified plasma thrombin and fibrin generation by intact or degraded NETs and cell-free (cf) DNA fragments, and found that digested NETs and short DNA fragments were more thrombogenic than intact NETs and high molecular weight genomic DNA, respectively. PF4 reduced the thrombogenicity of digested NETs and DNA by interfering, in part, with contact pathway activation. In endothelial cell culture studies, short DNA fragments promoted von Willebrand factor release and tissue factor expression via a toll-like receptor 9-dependent mechanism. PF4 blocked these effects. C<i>xcl4</i><sup>-/-</sup> mice infused with cfDNA exhibited higher plasma thrombin anti-thrombin (TAT) levels compared to wild-type controls. Following challenge with bacterial lipopolysaccharide, C<i>xcl4</i><sup>-/-</sup> mice had similar elevations in plasma TAT and cfDNA, effects prevented by PF4 infusion. Thus, NET-stabilization by PF4 prevents the release of short fragments of cfDNA, limiting the activation of the contact coagulation pathway and reducing endothelial injury. These results support our hypothesis that NET-stabilization reduces pathologic sequelae in sepsis, an observation of potential clinical benefit.
Preparation of Nickel Phosphide Hydrodesulfurization Catalysts Assisted by Supercritical Carbon Dioxide (2015)

Abstract The front cover artwork for Issue 21/2015 is a collaboration between the Catalysis &amp; Separation Division, IFPEN and ICMCB–CNRS. The image shows a new preparation method to obtain silica‐supported nickel phosphide nanoparticles assisted by supercritical carbon dioxide and their application to hydrodesulfurization. See the Communication itself at http://dx.doi.org/10.1002/cctc.201500755 .
Disposition and oral bioavailability of amoxicillin and clavulanic acid in pigs (2007)

The pharmacokinetic properties of amoxicillin and clavulanic acid were studied in healthy, fasted pigs after single intravenous (i.v.) and oral (p.o.) dosage of 20 mg/kg of amoxicillin and 5 mg/kg of clavulanic acid. The plasma concentrations of the drugs were determined by validated high-performance liquid chromatographic methods and the pharmacokinetic parameters were calculated by compartmental and noncompartmental analyses. After i.v. administration of the two drugs, plasma concentration-time curves were best described by a three-compartmental open model for amoxicillin and a two-compartmental open model for clavulanic acid. Amoxicillin (with a t(1/2 gamma) = 1.03 h and a clearance of 0.58 L/h.kg) and clavulanic acid (with a t(1/2 beta) of 0.74 h and a clearance of 0.41 L/h.kg) were both rapidly eliminated from plasma. Both drugs had apparently the same volume of distribution of 0.34 L/kg. After p.o. administration of the two drugs, a noncompartmental model was used. Elimination half-lives of amoxicillin and clavulanic acid were not significantly different, i.e. 0.73 and 0.67 h respectively. The mean maximal plasma concentrations of amoxicillin and clavulanic acid were 3.14 and 2.42 mg/L, and these were reached after 1.19 and 0.88 h respectively. The mean p.o. bioavailability was found to be 22.8% for amoxicillin and 44.7% for clavulanic acid.
Supplementary Table 1 from Whole-Genome and Transcriptional Analysis of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer Demonstrates Intraclass Heterogeneity (2023)

&lt;p&gt;Supplementary Table 1. Clinical Characteristics of the Whole Genome Sequencing Cohort&lt;/p&gt;
On-chip optical squeezing and quantum correlations (2014)

We present optical twin-beam squeezing from a CMOS-compatible on-chip optical parametric oscillator operating above threshold. At higher pump powers, we observe correlations among modes in the generated frequency comb.
Modeling of Fluid Balancer in Tilted Type Automatic Washing Machine (2018)

The abstract must be written in English. Type the text body in 9 point letters with the length of 100 words or less and should explain the substantial points of the paper you will be presenting.
Active movements in plants (2008)

The Venus flytrap (Dionaea muscipula Ellis) captures insects with one of the most rapid movements in the plant kingdom. We investigated trap closure by mechanical and electrical stimuli using the novel charge-injection method and high-speed recording. We proposed a new hydroelastic curvature mechanism, which is based on the assumption that the lobes possess curvature elasticity and are composed of outer and inner hydraulic layers with different hydrostatic pressure. The open state of the trap contains high elastic energy accumulated due to the hydrostatic pressure difference between the hydraulic layers of the lobe. Stimuli open pores connecting the two layers, water rushes from one hydraulic layer to another, and the trap relaxes to the equilibrium configuration corresponding to the closed state. In this paper we derived equations describing this system based on elasticity Hamiltonian and found closing kinetics. The novel charge-injection stimulation method gives insight into mechanisms of the different steps of signal transduction and response in the plant kingdom.
Distributed Index for Multi-dimensional Data in Sensor Networks (2003)

In many sensor network applications, data or events are named by attributes. Many of these attributes have scalar values, so one natural way to query events of interest is to use a multi-dimensional range query. An example of such a range query is: âÂ¡Ãlist all events whose temperature lies between 50 degree and 60 degree, and whose light levels lie between 10 and 15. Such queries are useful for correlating events occurring within the network represented by different attribute values. In this demo, we will demonstrate an implementation of a distributed index that scalably supports multi-dimensional range queries. Our distributed index for multi-dimensional data
Rapid isolation and sequencing of purified plasmid DNA from Bacillus subtilis (1993)

We report two methods for isolation of plasmid DNA from the gram-positive bacterium Bacillus subtilis. The protoplast alkaline lysis procedure was developed for general use, and the protoplast alkaline lysis magic procedure was developed for isolation of DNA for sequencing. Both procedures yielded large amounts of high-quality DNA in less than 1 h, while current protocols require 4 to 7 h to perform and give lower yields and quality. Plasmid DNA was obtained from strains containing either high- or low-copy-number plasmids. In addition, the procedures were easily adapted to yield large amounts of plasmid DNA suitable for sequencing from another gram-positive organism, Staphylococcus aureus. Further, we demonstrated that neither chloramphenicol, used for plasmid selection, nor the mutation recE4 reduced plasmid DNA yield from the strains we examined.
A Fully Integrated DAC for CMOS Position-Based Charge Qubits with Single-Electron Detector Loopback Testing (2020)

This letter presents a fully integrated interface circuitry with a position-based charge qubit structure implemented in 22-nm FDSOI CMOS. The quantum structure is controlled by a tiny capacitive DAC (CDAC) that occupies 3.5×45 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and consumes 0.27mW running at a 2-GHz system clock. The state of the quantum structure is measured by a single-electron detector that consumes 1 mW (including its output driver) with an area of 40×25 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The low power and miniaturized layout of these circuits pave the way for integration in a large quantum core with thousands of qubits, which is a necessity for practical quantum computers. The CDAC output noise of 12 μV-rms is estimated through mathematical analysis while the ≤ 0.225 mV-rms input referred noise of the detector is verified by measurements at 3.4K. The functionality of the system and performance of the CDAC are verified in a loopback mode with the detector sensing the CDAC-induced electron tunneling from the floating diffusion node into the quantum structure.
On the mechanism of marine fouling-prevention performance of oil-containing silicone elastomers: A comprehensive laboratory, field and theoretical study (2022)

Abstract For many decades, silicone elastomers with oil incorporated have served as fouling-release coating for marine applications. In a comprehensive study involving a series of laboratory-based marine fouling assays and extensive global field studies of up to 2-year duration, we compare polydimethylsiloxane (PDMS) coatings of the same composition loaded with oil. Methods using a traditional, one-pot pre-cure oil addition approach (o-PDMS) and a newer post-cure infusion approach (i-PDMS) were evaluated. The latter display a substantial increase in biofouling prevention performance that exceeds an established commercial silicone-based fouling-release coating standard. We interpret the differences in performance between one-pot and infused PDMS by developing a mechanistic model based on the Flory-Rehner theory of swollen polymer networks. Using this model, we propose that the chemical potential of the incorporated oil is a key consideration for the design of future fouling-release coatings, as the improved performance is driven by the formation and stabilization of an anti-adhesion oil overlayer on the polymer surface.
The Manifold Particle Filter for State Estimation on High-dimensional Implicit Manifolds (2016)

We estimate the state a noisy robot arm and underactuated hand using an Implicit Manifold Particle Filter (MPF) informed by touch sensors. As the robot touches the world, its state space collapses to a contact manifold that we represent implicitly using a signed distance field. This allows us to extend the MPF to higher (six or more) dimensional state spaces. Earlier work (which explicitly represents the contact manifold) only shows the MPF in two or three dimensions. Through a series of experiments, we show that the implicit MPF converges faster and is more accurate than a conventional particle filter during periods of persistent contact. We present three methods of sampling the implicit contact manifold, and compare them in experiments.
Sm^2+ → Nd^3+ energy transfer in CaF_2 (1986)

We measured the energy-transfer efficiency of Sm2+ → Nd3+ in CaF2 and found that the transfer occurs through the dipole–dipole interaction. Our calculations of the efficiency from the emission and absorption properties of the Sm2+ and Nd3+ ions are in good agreement with those obtained from the Foerster–Dexter analysis of the emission transients. In addition, the comparison of the excitation and absorption spectra of codoped samples quantitatively confirms that energy initially absorbed by Sm2+ is actually being converted into Nd3+ luminescence. Although efficiencies of 0.9 can be achieved with reasonable levels of Nd3+ doping, the Sm2+ luminescence begins to quench at temperatures >220 K. The selection of an optimal host for application to solid-state laser systems is discussed in the light of the Sm2+ spectral characteristics and the need for good efficiency at room temperature.
[Paper] Digital Calibration for a 2-Stage Cyclic Analog-to-Digital Converter Used in a 33-Mpixel 120-fps SHV CMOS Image Sensor (2014)

A digital calibration algorithm is proposed for a 2-stage cyclic analog-to-digital converter (ADC) with 12-bit resolution used in a 33-Mpixel 120-fps CMOS image sensor for Super High-Vision. This algorithm can correct errors generated in the ADC due to capacitor mismatch, finite gain error, and incomplete settling error. A simulation was performed to verify the proposed algorithm. The results show that the maximum differential nonlinearity (DNL) is improved to +0.49 / -0.48 LSB from +4.5 / -1.5 LSB, and the maximum integral nonlinearity (INL) is improved to +0.23 / -0.27 LSB from +7.5 / -1.5 LSB.
A Parametric Analysis of Embedded Tissue Marker Properties and Their Effect on the Accuracy of Displacement Measurements (2021)

Datasets obtained from cadaveric experimentation are broadly used in validating finite element models of head injury. Due to the complexity of such measurements in soft tissues, experimentalists have relied on tissue-embedded radiographic or sonomicrometry tracking markers to resolve tissue motion caused by impulsive loads. Dynamic coupling of markers with the surrounding tissue has been a previous concern, yet a thorough sensitivity investigation of marker influences on tissue deformation has not been broadly discussed. Technological improvements to measurement precision have bolstered confidence in acquired data; however, precision is often conflated with accuracy; the inclusion of markers in the tissue may alter its natural response, resulting in a loss of accuracy associated with an altered displacement field. To gain an understanding of how marker properties may influence the measured response to impact, we prepared a set of nine marker designs using a Taguchi L9 array to investigate marker design choice sensitivity. Each of these designs was cast into a block of tissue simulant and subjected to repeated drop tests. Vertical displacement was measured and compared to the response of the neat material, which contained massless tracking markers. Medium density and medium stiffness markers yielded the least deviation from the neat material response. The results provide some design guidelines indicating the importance of maintaining marker matrix density ratio below 1.75 and marker stiffness below 1.0 MPa. These properties may minimize marker interference in tissue deformation. Overall, embedded marker properties must be considered when measuring the dynamic response of tissue.
[THE MALADAPTIVE BELIEFS OF PATIENTS WITH LOW BACK PAIN. A NARRATIVE REVIEW]. (2016)

Misbeliefs are frequent in patient with low back pain. They do need to be looked for and corrected.
Spatiotemporal strategies to identify aggressive biology in precancerous breast biopsies (2020)

Over 90% of breast cancer is cured; yet there remain highly aggressive breast cancers that develop rapidly and are extremely difficult to treat, much less prevent. Breast cancers that rapidly develop between breast image screening are called "interval cancers." The efforts of our team focus on identifying multiscale integrated strategies to identify biologically aggressive precancerous breast lesions. Our goal is to identify spatiotemporal changes that occur prior to development of interval breast cancers. To accomplish this requires integration of new technology. Our team has the ability to perform single cell in situ transcriptional profiling, noncontrast biological imaging, mathematical analysis, and nanoscale evaluation of receptor organization and signaling. These technological innovations allow us to start to identify multidimensional spatial and temporal relationships that drive the transition from biologically aggressive precancer to biologically aggressive interval breast cancer. This article is categorized under: Cancer > Computational Models Cancer > Molecular and Cellular Physiology Cancer > Genetics/Genomics/Epigenetics.
TAXI: Trace Analysis for x86 Interpretation (2003)

Although x86 processors have been around for a long time and are the most ubiquitous processors in the world, the amount of academic research regarding details of their performance has been minimal. We introduce an x86 simulation environment, called TAXI (Trace Analysis for X86 Interpretation), and use it to present results for eight Win32 applications. In this paper, we explain the design and implementation of TAXI.
Partial discharges in motor wires at PWM voltages of different smoothness (2014)

Author's recent work has been focused on exploring possibilities for measuring partial discharges (PDs) under the action of pulse width modulated waveforms (PWM), which resulted in a development of an electrical measurement method adopted for such voltages. This solution allows a more flexible PD analysis since voltage shapes appearing in service can be utilized. In this paper, results are presented where several waveforms are applied to quantify the PD properties for motor wire test objects, starting from a non-filtered PWM waveform and continuing with gradually smoothened ones towards an AC voltage shape. The results suggest that non-smoothed PWM voltage introduces considerably more PDs and with larger magnitudes, which most probably influences the lifetime of the insulation system in all tested cases. Additionally, above a certain level of filtering, the use of lower carrier frequencies implies higher PD exposure, which suggests that the filters used should be evaluated together with the carrier frequency to ensure a longer lifetime of the insulation. It was also observed that the changes in duty cycle reduce the PD density at higher frequencies. This suggests that only applying square voltage waveforms with 50 % duty cycle for PD testing may fail to capture the actual stress inflicted.
222 Structural Optimization of Three Axes Tactile Sensor by Using DOE (2006)

This paper describes about the structural optimization of a three axes tactile sensor. This tactile sensor can detect three axes forces simultaneously by strain gauges. The sensor consists of a top surface and four legs which are made of brass. In this paper, based on the output principles of the tactile sensor, the relationship between the responses and the design variables is clarified by FEM and DOE. Additionally approximate expressions are obtained by GLM. Using these results, the best design variables of the three axes tactile sensor are obtained.
Extending the Resolution of Emission Images beyond Diffraction Limits Using Deconvolution (2016)

Abstract In this work, we demonstrate the effectiveness of deconvolution algorithms in improving the spatial resolution of time-integrated emission images from integrated circuits. A mathematical model of the Point Spread Function (PSF) encompassing both the optical system and the imaging detector properties is used for the deconvolution process. Tuning of the PSF parameters is achieved through the minimization of dedicated cost functions that optimize image resolution while suppressing artifacts in the deconvoluted images. The optimized PSF is then used in both the Lucy-Richardson (L-R) and blind deconvolution algorithms. Results from 32 nm and 14 nm SOI devices show that the deconvolution process significantly improves spatial resolution of time-integrated emission images, pushing their resolution beyond the diffraction limit of Solid Immersion Lenses (SILs).
Levetiracetam Improves Upper Limb Spasticity in a Patient With Unresponsive Wakefulness Syndrome: A Case Report (2020)

Severe spasticity is a frequent and disabling complication in patients presenting disorders of consciousness (DOC) that hinders their rehabilitative process, and is strongly correlated with pain reducing patients' quality of life. In these patients, abnormal postures may occur as an expression of severe brain damage. Here we present the case of a 52-year-old man in decorticate rigidity following a hypoxic-ischemic encephalopathy due to myocardial infarction who showed improvement of spasticity of upper limbs following intake of levetiracetam combined with the conventional neurorehabilitation program.
Photodetectors monolithically integrated on SOI substrate for optical pickup using blue or near-infrared semiconductor laser (2002)

We made photodetectors on a silicon-on-insulator (SOI) substrate by a 0.35-/spl mu/m BiCMOS fabrication process to detect the signal light used in an optical disk system. Investigating their characteristics at two wavelengths, 410 and 780 nm, for different structures, we found that the thickness of the silicon crystalline layer on the insulator strongly affected the frequency response at the longer wavelength, while the cutoff frequency was over 500 MHz for the shorter wavelength. We also simulated the frequency response.
Conjugated Enynes as Nonaromatic Catechol Bioisosteres:  Synthesis, Binding Experiments, and Computational Studies of Novel Dopamine Receptor Agonists Recognizing Preferentially the D3Subtype (2000)

To evaluate nonaromatic catechol bioisosteres, the conformationally restrained enynes 1 and enediynes 2 were synthesized via palladium-catalyzed coupling as the key reaction step. Subsequent receptor binding studies at the dopamine receptor subtypes D(1), D(2 long), D(2 short), D(3), and D(4) showed highly interesting binding profiles for the enynes 1a and 1b when compared to dopamine. At the guanine nucleotide-sensitive high-affinity binding site of the D(3) receptor, the target compound 1b (K(i) = 5.2 nM) was 10-fold more potent than dopamine but less potent at the D(2) and D(4) subtypes. In contrast to dopamine the agonists 1a and 1b showed strong selectivity for the receptors of the D(2) family (D(2)-D(4)). As far as we know, this study represents the first report on nonaromatic dopamine agonists. Comparison of molecular electrostatic potentials, derived from semiempirical molecular orbital calculations, and lipophilicity maps was performed.
In Vitro Methods for Plant–Microbe Interaction and Biocontrol Studies in European Ash (Fraxinus excelsior L.) (2019)

In vitro tissue culture systems are required for plant–microbe interaction studies on European ash, Fraxinus excelsior. Methods are needed for plant micropropagation and for physiological experimentation including pathogen/resistance testing and biocontrol studies. For example, systems are required for experiments on ash dieback disease, caused by the ascomycete fungus Hymenoscyphus fraxineus, that is killing ash plantations and natural populations across its native range. Methods are also needed to optimise the number of endophytes cultured from ash tissue and to taxonomically identify them. We present endophyte isolation protocols and media for ash, provide an optimised DNA barcoding procedure for endophyte identification and describe in vitro tissue culture methods suitable for ash–microbe interaction studies in both roots and shoots. Methods for both embryo culture and seed culture (with precutting) and for the bulking up of genotypes via single node culture are outlined. We also discuss the potential of tissue culture for establishing microbe/endophyte-free cultures.