gebhart/patrepeval huggingface dataset:
Advances in Thin-Film Proton-Reaction Cell Experiments (2000)

Thin-film electrodes (layers of the order of thousands of angstroms) offer several very important advantages for cold fusion research: Good reproducibility has been demonstrated, an extremely high power density is obtained in the thin film, and reaction rates can be optimized by appropriate selection of materials and interfaces. The motivation for thin films stems from the Swimming Electron Theory, which predicts that enhanced reaction rates can occur with the careful selection of interface materials. Recent experiments have concentrated on the measurement of the H or D loading (atoms H/atom metal), using thin (1-m-long, 50-{mu}m-diam) wires to simulate thin films. Wires facilitate measurement of the loading as a function of time during a run by use of a simple resistivity measurement. These experiments show that excess heat production is associated with a dynamic resistivity oscillation, both being suddenly initiated (coincidence within 2 to 3 s) when a D/Pd loading ratio >0.9 9 is achieved. The counterpart of these experiments involves use of a unique compact electrode design where thin films are coated onto a small glass slide to provide both the anode and cathode. Experiments with these compact electrodes have consistently produced >100 W/cm{sup 3} metal.
Generation of sub-3 fs pulses in the deep ultraviolet (2010)

We demonstrate generation and measurement of intense deep-ultraviolet light pulses with a duration of approximately 2.8 fs (FWHM of the intensity envelope) and a wavelength distribution between 230 and 290 nm. They emerge via direct frequency upconversion of sub-4 fs laser pulses of a carrier wavelength of approximately 750 nm focused into an Ne-filled, quasi-static gas cell. Dispersion-free, third-order autocorrelation measurements provide access to their temporal intensity profile.
Abstract #1708: Voreloxin is active in breast cancer biopsies and potency is enhanced in a BRCA2 mutant background (2009)

Voreloxin is a novel naphthyridine analog, structurally related to the quinolones, and currently in clinical trials in acute myeloid leukemia (AML) and platinum-resistant ovarian cancer. Clinical responses have been observed in these indications (Lancet et al., 2007; McGuire et al., SGO 2008). Voreloxin\#8217;s mechanism of action involves DNA intercalation and inhibition of topoisomerase II that induces site-selective DNA double-strand breaks (DSB), G2 arrest and apoptosis. Potency was reported in primary patient biopsies from triple negative breast cancer, ovarian cancer and AML, including samples that are resistant to the topoisomerase II inhibitor doxorubicin, with activity independent of p53 family members (Hawtin et al AACR 2008). Here we report that toxic DSBs are generated at the replication fork, triggering homologous recombination repair (HRR) and that BRCA2 mutation increases sensitivity to voreloxin. We also show that the agent is active in breast cancer biopsies from patients with ductal or metastatic disease. The influence of BRCA2 on sensitivity to voreloxin was evaluated by proliferation assay in cells mutant and complemented for functional BRCA-2 (V-C8 and V-C8-B2). Activity in these assays was compared with doxorubicin. In cells mutant for BRCA2 an approximately 5-fold increase in sensitivity was identified for voreloxin as compared to cells expressing functional BRCA2 (IC 50 0.14 \#956;M vs 0.72 \#956;M). Doxorubicin sensitivity was increased approximately 4-fold (IC 50 0.05 \#956;M vs 0.19 \#956;M ). These studies were extended to the human sarcoma cell line U-20S, comparing wild-type cells to those depleted for BRCA2 using siRNA. The BRCA2 influence on sensitivity to voreloxin was evaluated by clonogenic survival and compared with doxorubicin. Voreloxin cytotoxicity toward 9 ductal and 8 metastatic primary breast cancer biopsies was determined using the Extreme Drug Resistance (EDR) proliferation assay. Voreloxin was potent in samples that were resistant to the topoisomerase II inhibitors doxorubicin and / or etoposide, and was also active in cisplatin-resistant samples. Voreloxin at 1µM (the plasma concentration sustained for approximately 24 hr in Phase 2 clinical studies) inhibited proliferation >90% in 8/9 ductal biopsies, with none being resistant to the agent. Proliferation was also inhibited >90% in 4/8 metastatic samples with only one being resistant to 1µM voreloxin. In conclusion, voreloxin induces DNA DSBs that are repaired by HRR, and BRCA2 mutations sensitize cells to the agent. Voreloxin is active in breast cancer biopsies, including those resistant to other topoisomerase II inhibitors. Combined with potent activity in triple-negative breast cancer biopsies and the known mechanism of action of voreloxin, these data support expansion of the clinical evaluation of voreloxin to include breast cancer, in which other topoisomerase II inhibitors are active. Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 1708.
The effects of the fabric properties on fabric movement and the prediction of the fabric movements in a front-loading washer (2013)

The purpose of this study is to determine the effects of the fabric properties on fabric movement and to suggest a prediction model for the fabric movements in a front-loading washer. During a wash cycle, the fabric moves in many different ways depending on the mechanical and physiochemical properties of the fabric. In this study, 14 different fabrics were measured for their mechanical and physiochemical properties by the Kawabata Evaluation System (KES) and the water absorption test. From the observation of the fabric movements in the washer, 13 movement indexes were derived, and the relationships between the fabric properties and fabric movements were studied. The critical fabric properties that affected the fabric movements were determined by the analysis of variance (one-way ANOVA) and the post hoc test using the Scheffe method. The major fabric properties that affected fabric movements were found to be fabric weight, drape coefficient, water content, shear recovery, compression linearity, and energy required for compression. These fabric properties were investigated for their relation with the fabric movement indexes. The predicting models for fabric movements were suggested by the multi-linear regression equations.
Supplementary Table 4 from A 12-Gene Set Predicts Survival Benefits from Adjuvant Chemotherapy in Non–Small Cell Lung Cancer Patients (2023)

&lt;p&gt;PDF file - 104K, Members of the 18-hub gene signature have been included in MSigDB database C2 signature catalogues.&lt;/p&gt;
Highly Efficient Smart Battery Pack for EV Drivetrains (2017)

This paper introduces a Smart Battery Pack (SBP) for Electric Vehicles (EV) application where many Li-ion battery cells connected in series are need to be balanced. The advantages of SBP over conventional methods are high efficiency, low switching frequency, and simple topology. Solution is brought by connecting battery-cells using half bridges which allows inserting or bypassing a cell based on its current state of charge (SOC), thereby balancing. Consequently, the output voltage is reduced by the overall voltage of bypassed cells. Simulation results show comparison between SBP and series connected battery pack in terms of battery utilization and discharging time.
Glucocorticoid receptor signalling activates YAP in breast cancer (2017)

The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activation of the transcription co-activator YAP (Yes-associated protein) that contributes to tumorigenesis in several tissues. Here we identify glucocorticoids (GCs) as hormonal activators of YAP. Stimulation of glucocorticoid receptor (GR) leads to increase of YAP protein levels, nuclear accumulation and transcriptional activity in vitro and in vivo. Mechanistically, we find that GCs increase expression and deposition of fibronectin leading to the focal adhesion-Src pathway stimulation, cytoskeleton-dependent YAP activation and expansion of chemoresistant cancer stem cells. GR activation correlates with YAP activity in human breast cancer and predicts bad prognosis in the basal-like subtype. Our results unveil a novel mechanism of YAP activation in cancer and open the possibility to target GR to prevent cancer stem cells self-renewal and chemoresistance.
A phase-space beam summation formulation for ultrawide-band radiation (2004)

A new discrete phase space Gaussian beam (GB) summation representation for ultrawide-band (UWB) radiation from an aperture source distribution is presented. The formulation is based on the theory of the windowed Fourier transform (WFT) frames, wherein we introduce a novel relation between the frequency and the frame overcompleteness. With this procedure, the discrete lattice of beams that are emitted by the aperture satisfies the main requirement of being frequency independent, so that only a single set of beams needs to be traced through the medium for all the frequencies in the band. It is also shown that a properly tuned class of iso-diffracting (ID) Gaussian-windows provides the "snuggest" frame representation for all frequencies, thus generating stable and localized expansion coefficients. Furthermore, due to the ID property, the resulting GBs propagators are fully described by frequency independent matrices whose calculation in the ambient environment need to be done only once for all frequencies. Consequently, the theory may also be expressed directly in the time-domain as will be presented elsewhere. The localization implied by the new formulation is demonstrated numerically for an UWB focused aperture. It is shown that the algorithm extracts the local radiation properties of the aperture source and enhances only those beams that conform with these properties, i.e., those residing near the phase space Lagrange manifold. Further localization is due to the fact the algorithm accounts only for beams that pass within a few beamwidths vicinity of the observation point. It is thus shown that the total number of beams is much smaller than the Landau Pollak bound on the aperture's degrees of freedom.
Human Substance P Receptor Expressed in Sf9 Cells Couples with Multiple Endogenous G Proteins (1998)

To identify the G proteins involved in the function of human substance P receptor (hSPR), the receptor was expressed in Sf9 cells using the baculovirus expression system. Maximal hSPR expression was up to 65 pmol/mg membrane protein. The following data indicated that hSPR in Sf9 membranes is coupled to endogenous G proteins: 1) binding of agonist radioligand [125I]BHSP to the receptor was sensitive to guanine nucleotides; and 2) stimulation of the receptor increased [35S]GTPgammaS binding. The hSPR-associated G proteins were identified by photoaffinity labeling with [alpha-32P]-azidoanilido GTP ([alpha-32P]AAGTP), followed by immunoprecipitation of the labeled G proteins with antibodies specific for various Galpha-subunits. These experiments showed that stimulation of hSPR in Sf9 membranes activated multiple endogenous G proteins including Galpha(o), Galpha(q/11), and Galpha(s). While hSPR's ability to associate with Gq/11 is well-documented, the present study provides the first evidence of hSPR's potential to activate Galpha(o) and Galpha(s).
Measurement of chirp parameters and halfwave voltages of Mach-Zehnder-type optical modulators by using a small signal operation (2003)

A method is described for measuring the chirp parameters and the halfwave voltages of Mach-Zehnder-type optical modulators. These parameters can be obtained from the optical spectrum components by using a small signal operation, while the conventional method needs large voltages. We demonstrated the measurement of the frequency responses up to 40 GHz.
Non-Polarographic Blood Gas Analysis III.

In Vitro

Evaluation of Mass Spectrometer Catheters (1980)

Four commercially available medical mass spectrometer catheters capable of providing in vivo blood gas data are evaluated. Accuracy and flow dependency data are presented on each and relative strengths and weaknesses for particular uses are discussed.
An Integrated CMOS Detector for MR Image Guided Interventions (2010)

In this work, standard CMOS technology is used to miniaturize highly integrated active tracking devices in MR image guided interventions. The presented microsystem contains a detection coil, a tuning capacitor, a low-noise amplifier, a downconversion mixer and a low-frequency gain stage on a single integrated circuit. Downconverting the NMR signal to a few kilohertz on chip significantly reduces losses in the cables and thereby facilitates the use of the system in small catheters. The feasibility of the approach is demonstrated with phantom experiments in a standard 1.5 T clinical scanner.
Nanometer-deep junctions with high doping concentration for Ge SDEs using solid source doping and flash lamp annealing (2017)

In recent years Solid Source Doping (SSD) has been considered as a viable option in fabricating advanced CMOS devices [1], especially for forming shallow and highly doped junctions for source drain extensions (SDE) while minimizing the damage to the devices [2]. Current scaled devices require diffusion control in the nanometer range in order to form shallow SDEs using SSD. Additionally, high doping concentrations are needed to lower the resistivity (see Fig. 1).
Nontypeable Haemophilus influenzae Lipooligosaccharide Expresses a Terminal Ketodeoxyoctanoate In Vivo , Which Can Be Used as a Target for Bactericidal Antibody (2018)

Nontypeable <i>Haemophilus influenzae</i> (NTHi) is an important pathogen in individuals of all ages. The lipooligosaccharide (LOS) of NTHi has evolved a complex structure that can be attributed to a multiplicity of glycosyltransferases, the random switching of glycosyltransferase gene expression via phase variation, and the complex structure of its core region with multiple glycoform branch points. This article adds to that complexity by describing a multifunctional enzyme (LsgB) which optimally functions when the species is grown on a solid surface and which can add either a ketodeoxyoctanoate (KDO) or an <i>N</i>-acetylneuramic acid (Neu5Ac) moiety to a terminal <i>N-</i>acetyllactosamine structure of LOS. Our studies show that expression of <i>lsgB</i> is reduced four- to sixfold when NTHi is grown in broth. The substrate that the enzyme utilizes is dependent upon the concentration of free Neu5Ac (between 1 and 10 µg/ml) in the environment. In environments in which Neu5Ac is below that level, the enzyme utilizes endogenous CMP-KDO as the substrate. Our studies show that during <i>in vivo</i> growth in an NTHi biofilm, the KDO moiety is expressed by the organism. Monoclonal antibody 6E4, which binds KDO, is bactericidal for NTHi strains that express the KDO epitope at high levels. In a survey of 33 NTHi strains isolated from healthy and diseased individuals, the antibody was bactericidal (>90% kill) for 12 strains (36%). These studies open up the possibility of using a KDO-based glycoconjugate vaccine as part of a multicomponent vaccine against NTHi.<b>IMPORTANCE</b> Nontypeable <i>Haemophilus influenzae</i> is an important pathogen in middle ear infections in children, sinusitis in adults, and acute bronchitis in individuals with chronic obstructive lung disease. The organism is very well adapted to the human host environment, and this has hindered successful development of an effective vaccine. In this article, we describe a mechanism by which the bacteria decorates its surface lipooligosaccharide with a sugar unique to Gram-negative bacteria, ketodeoxyoctanoate (KDO). This sugar decoration is present during active infection and we have shown that an antibody directed against this sugar can result in killing of the organism. These data demonstrate that the lipooligosaccharide ketodeoxyoctanoate epitope may be a novel NTHi<i>-</i>specific candidate vaccine antigen.
Simultaneous expression of keratin and glial fibrillary acidic protein by the same cells in epiretinal membranes. (1992)

The identification of cells comprising epiretinal membranes is difficult because of the phenotypic changes that occur. Examination of intermediate filament protein content by immunocytochemical analysis can help to identify some cells with altered ultrastructure but is not always definitive because altered expression of intermediate filament proteins can also occur. To examine this issue further, the authors utilized a postembedding immunocytochemical technique with epiretinal membranes in which they were able to double label for keratin, a useful marker for identifying retinal pigment epithelial cells, and glial fibrillary acidic protein (GFAP), a useful marker for identifying glial cells. Nine of ten idiopathic epiretinal membranes contained cells that labeled for GFAP and not keratin. Two of these membranes also contained cells that labeled only for keratin and one membrane contained cells that simultaneously labeled for both GFAP and keratin. Other types of epiretinal membranes had an equal participation by cells that expressed only GFAP or keratin (12 of 17 membranes contained cells positive for keratin; 13 of 17 contained cells positive for GFAP). Ten of 17 nonidiopathic membranes contained cells simultaneously expressing GFAP and keratin, although they comprised only a minor subpopulation of the total number of cells present. These findings demonstrate that keratin and GFAP are not mutually exclusive intermediate filament proteins in cells of epiretinal membranes and that, although each may provide a helpful adjunct for cell type identification, neither is an absolutely specific marker.
Simulation on Computational Fluid Dynamics of Flow Field and Pollutant Dispersion in Block of Buildings (2013)

With the social development, motor vehicle exhaust has become a major source of pollution in the city today, so it is necessary to research the effect of the wind field around buildings and pollutants dispersion on human health. In this paper, we using Fluid Dynamics method to simulate the pollutants dispersion under different wind direction. The results showed that the maximum wind speed of the buildings in the same horizontal plane appeared in the entrance of the street. When the inflow velocity, wind directions are different, the air flow distribution is different in group of buildings. Pollutants are prone to accumulate in the place of low wind speed, atmospheric instability, and weak turbulence intensity. The concentration of pollutants from lower to upper gradually reduced, but it will appear opposite situation in the vortex.
Transaxial system models for jPET-D4 image reconstruction (2005)

A high-performance brain PET scanner, jPET-D4, which provides four-layer depth-of-interaction (DOI) information, is being developed to achieve not only high spatial resolution, but also high scanner sensitivity. One technical issue to be dealt with is the data dimensions which increase in proportion to the square of the number of DOI layers. It is, therefore, difficult to apply algebraic or statistical image reconstruction methods directly to DOI-PET, though they improve image quality through accurate system modelling. The process that requires the most computational time and storage space is the calculation of the huge number of system matrix elements. The DOI compression (DOIC) method, which we have previously proposed, reduces data dimensions by a factor of 1/5. In this paper, we propose a transaxial imaging system model optimized for jPET-D4 with the DOIC method. The proposed model assumes that detector response functions (DRFs) are uniform along line-of-responses (LORs). Then each element of the system matrix is calculated as the summed intersection lengths between a pixel and sub-LORs weighted by a value from the DRF look-up-table. 2D numerical simulation results showed that the proposed model cut the calculation time by a factor of several hundred while keeping image quality, compared with the accurate system model. A 3D image reconstruction with the on-the-fly calculation of the system matrix is within the practical limitations by incorporating the proposed model and the DOIC method with one-pass accelerated iterative methods.
Echology (2005)

We present a novel way of manipulating a spatial soundscape, one that encourages collaboration and exploration. Through a table-top display surrounded by speakers and lights, participants are invited to engage in peaceful play with Beluga whales shown through a live web camera feed from the Vancouver Aquarium in Canada. Eight softly glowing buttons and a simple interface encourage collaboration with others who are also enjoying the swirling Beluga sounds overhead.
The Pathology Residency Program of the Johns Hopkins University School of Medicine: A Model of Its Kind (2015)

While maintaining its original core values, the Johns Hopkins Pathology Residency Program has trained physicians to be outstanding researchers, diagnosticians, and leaders in pathology.
SEM Observations on the Marine Nematode Dracognomus simplex (Gerlach, 1954) Allen and Noffsinger, 1978 (Draconematidae: Prochaetosomatinae). (2002)

The free-living marine nematode Dracognomus simplex (Gerlach, 1954) Allen &Noffsinger, 1978 was studied by scanning electron microscopy (SEM). The morphology of males and females is described and illustrated in detail. In addition to the typical and modified adhesion tubes, a new type of posterior adhesion tube was discovered. A neotype is proposed for Dracognomus simplex, and D. simplex sensu Decraemer &Gourbault, 1986 is renamed as Dracognomus americanum n. sp. Additionally, a key toward the Dracognomus species is proposed.
Characterization of the Activity Spectrum of MON 88702 and the Plant-Incorporated Protectant Cry51Aa2.834_16 (2017)

The spectrum of insecticidal activity of Cry51Aa2.834_16 protein targeting hemipteran and thysanopteran insect pests in cotton was characterized by selecting and screening multiple pest and non-pest species, based on representation of ecological functional groups, taxonomic relatedness (e.g. relationship to species where activity was observed), and availability for effective testing. Seven invertebrate orders, comprising 12 families and 17 representative species were screened for susceptibility to Cry51Aa2.834_16 protein and/or the ability of the protein to protect against feeding damage in laboratory, controlled environments (e.g. greenhouse/growth chamber), and/or field studies when present in cotton plants. The screening results presented for Cry51Aa2.834_16 demonstrate selective and limited activity within three insect orders. Other than Orius insidiosus, no activity was observed for Cry51Aa2.834_16 against several groups of arthropods that perform key ecological roles in some agricultural ecosystems (e.g. pollinators, decomposers, and natural enemies).
Chiral N‐Heterocyclic Carbene/Pyridine Ligands for the Iridium‐Catalyzed Asymmetric Hydrogenation of Olefins (2013)

Tausche N,P gegen C,N! Iridium-Komplexe von zweizähnigen Pyridin-basierten C,N-Liganden mit einem N-heterocyclischen Carben (NHC) erwiesen sich als effiziente und enantioselektive Hydrierungskatalysatoren. Aus NHC-basierten Komplexen erzeugte Iridiumhydrid-Intermediate sind wegen ihrer niedrigeren Acidität besser für die Hydrierung säureempfindlicher Substrate geeignet als analoge Komplexe mit N,P-Liganden. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.