gebhart/patrepeval huggingface dataset:
TRPV2: A Cancer Biomarker and Potential Therapeutic Target (2020)

The Transient Receptor Potential Vanilloid type-2 (TRPV2) channel exhibits oncogenicity in different types of cancers. TRPV2 is implicated in signaling pathways that mediate cell survival, proliferation, and metastasis. In leukemia and bladder cancer, the oncogenic activity of TRPV2 was linked to alteration of its expression profile. In multiple myeloma patients, TRPV2 overexpression correlated with bone tissue damage and poor prognosis. In prostate cancer, TRPV2 overexpression was associated with the castration-resistant phenotype and metastasis. Loss or inactivation of TRPV2 promoted glioblastoma cell proliferation and increased resistance to CD95-induced apoptotic cell death. TRPV2 overexpression was associated with high relapse-free survival in triple-negative breast cancer, whereas the opposite was found in patients with esophageal squamous cell carcinoma or gastric cancer. Another link was found between TRPV2 expression and either drug-induced cytotoxicity or stemness of liver cancer. Overall, these findings validate TRPV2 as a prime candidate for cancer biomarker and future therapeutic target.
An Innovative Approach for Community Engagement: Using an Audience Response System. (2012)

Community-based participatory research methods allow for community engagement in the effort to reduce cancer health disparities. Community engagement involves health professionals becoming a part of the community in order to build trust, learn from the community and empower them to reduce disparities through their own initiatives and ideas. Audience Response Systems (ARS) are an innovative and engaging way to involve the community and obtain data for research purposes using keypads to report results via power point. The use of ARS within communities is very limited and serves to widen the disparity gap by not delivering new advances in medical knowledge and technology among all population groups. ARS was implemented at a community town hall event sponsored by a National Institute on Minority Health and Health Disparities Exploratory Center of Excellence, the Center for Equal Health. Participants appreciated being able to see how everyone else answered and felt included in the research process. ARS is beneficial because the community can answer truthfully and provides instant research results. Additionally, researchers can collect large amounts of data quickly, in a non-threatening way while tracking individual responses anonymously. Audience Response Systems proved to be an effective tool for successfully accomplishing community-based participatory research.
Early Covert Appearance of Marginal Zone B Cells in Salivary Glands of Sjögren′s Syndrome-Susceptible Mice: Initiators of Subsequent Overt Clinical Disease (2021)

The C57BL/6.NOD-<i>Aec1Aec2</i> mouse model has been extensively studied to define the underlying cellular and molecular bioprocesses critical in the onset of primary Sjögren's Syndrome (pSS), a human systemic autoimmune disease characterized clinically as the loss of lacrimal and salivary gland functions leading to dry eye and dry mouth pathologies. This mouse model, together with several gene knockout mouse models of SS, has indicated that B lymphocytes, especially marginal zone B (MZB) cells, are necessary for development and onset of clinical manifestations despite the fact that destruction of the lacrimal and salivary gland cells involves a classical T cell-mediated autoimmune response. Because migrations and functions of MZB cells are difficult to study in vivo, we have carried out ex vivo investigations that use temporal global RNA transcriptomic analyses to profile autoimmunity as it develops within the salivary glands of C57BL/6.NOD-<i>Aec1Aec2</i> mice. Temporal profiles indicate the appearance of Notch2-positive cells within the salivary glands of these SS-susceptible mice concomitant with the early-phase appearance of lymphocytic foci (LF). Data presented here identify cellular bioprocesses occurring during early immune cell migrations into the salivary glands and suggest MZB cells are recruited to the exocrine glands by the upregulated Cxcl13 chemokine where they recognize complement (C')-decorated antigens via their sphingosine-1-phosphate (S1P) and B cell (BC) receptors. Based on known MZB cell behavior and mobility, we propose that MZB cells activated in the salivary glands migrate to splenic follicular zones to present antigens to follicular macrophages and dendritic cells that, in turn, promote a subsequent systemic cell-mediated and autoantibody-mediated autoimmune T cell response that targets exocrine gland cells and functions. Overall, this study uses the power of transcriptomic analyses to provide greater insight into several molecular events defining cellular bioprocesses underlying SS that can be modelled and more thoroughly studied at the cellular level.
Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT) (2011)

Clostridium difficile infection (CDI) causes antibiotic-associated diarrhea and pseudomembranous colitis. Hypervirulent strains of the pathogen, which are responsible for increased morbidity and mortality of CDI, produce the binary actin-ADP ribosylating toxin Clostridium difficile transferase (CDT) in addition to the Rho-glucosylating toxins A and B. CDT depolymerizes the actin cytoskeleton, increases adherence and colonization of Clostridia by induction of microtubule-based cell protrusions and, eventually, causes death of target cells. Using a haploid genetic screen, we identified the lipolysis-stimulated lipoprotein receptor as the membrane receptor for CDT uptake by target cells. Moreover, we show that Clostridium perfringens iota toxin, which is a related binary actin-ADP ribosylating toxin, enters target cells via the lipolysis-stimulated lipoprotein receptor. Identification of the toxin receptors is essential for understanding of the toxin uptake and provides a most valuable basis for antitoxin strategies.
Patulin alleviates hepatic lipid accumulation by regulating lipogenesis and mitochondrial respiration (2023)

Patulin is a potent inducer of the AMPK pathway, and AMPK-mediated mitochondrial activation is required for the efficacy of patulin to inhibit hepatic lipid accumulation. This study is the first to report that patulin is a promising bioactive compound that prevents the development and worsening of fatty liver diseases, including non-alcoholic fatty liver disease, by improving mitochondrial quality and lipid metabolism.
Hiding Personal Tendency in Set-valued Database Publication (2019)

Set-valued database publication has been increasing its importance recently due to its benefit for various applications such as marketing analysis and advertising. However, publishing raw set-valued database may cause individual privacy breach such as the leakage of sensitive information like personal tendencies when data recipients perform data analysis.
Physics studies of neutronic problems related to the heterogeneous fast reactor core concept: experimental programme PRE-RACINE performed on MASURCA (1978)

To support the heterogeneous fast reactor core concept studies, CEA and CNEN have developed an important experimental program at Cadarache on the critical facility MASURCA. This programme includes two main parts PRE-RACINE programme (1976 to 1978), which is devoted to studies of elementary neutronic properties of one central internal fertile zone; and (2) The RACINE programme (1979 to 1981), which will consider a configuration with several fertile zones and control rods. Studies of axial zones inserted at the center of the core have also been performed. They confirm the tendencies observed with the complete central fertile zone. The analysis of these experiments will provide the calculation bias factors for the following parameters breeding gain, power distribution, and sodium void reactivity effects.
Abstract 3625: Do Patients Who Meet SCD-HeFT Criteria in Clinical Practice Differ from Patients Enrolled in SCD-HeFT? (2007)

Background: Many studies have demonstrated the lack of generalizability of randomized clinical trials’ findings to clinical practice. We conducted this study to determine whether the baseline characteristics of patients meeting SCD-HeFT criteria in the ACC-NCDR ICD Registry are similar to those of patients enrolled in SCD-HeFT. Methods: Of the 1,438 US hospitals participating in the ICD Registry, 85% submit data on all ICD implants. We identified patients with NYHA class II or III symptoms and an LVEF ≤ 35%. We excluded patients with an MI within 40 days, CABG within 1 month, and PCI within 3 months prior to ICD implantation. We also excluded patients who received an ICD for secondary prevention or an ICD with cardiac resynchronization therapy. Baseline characteristics were compared using the t-test for continuous variables and the chi-square test for categorical variables. Results: Patients in the ICD Registry are significantly older and have more co-morbidities than patients enrolled in SCD-HeFT (Table ). The rates of use of ACE-inhibitors and digoxin were significantly lower in the Registry than in the trial (p &lt;0.01 for both). The rates of use of beta-blockers, aspirin and statins were significantly higher in the Registry than in the trial (p &lt;0.01 for all) Conclusions: The baseline characteristics and medical management of patients who receive an ICD in clinical practice are significantly different from those of patients enrolled in SCD-HeFT. Future studies should investigate whether these differences translate into differences in ICD effectiveness.
An Electronic Throttle Control Strategy Including Compensation of Friction and Limp-Home Effects (2004)

An electronic throttle is a low-power dc servo drive which positions the throttle plate. Its application in modern automotive engines leads to improvements in vehicle drivability, fuel economy, and emissions. Transmission friction and the return spring limp-home nonlinearity significantly affect the electronic throttle performance. The influence of these effects is analyzed by means of computer simulations, experiments, and analytical calculations. A dynamic friction model is developed in order to adequately capture the experimentally observed characteristics of the presliding-displacement and breakaway effects. The linear part of electronic throttle process model is also analyzed and experimentally identified. A nonlinear control strategy is proposed, consisting of a proportional-integral-derivative (PID) controller and a feedback compensator for friction and limp-home effects. The PID controller parameters are analytically optimized according to the damping optimum criterion. The proposed control strategy is verified by computer simulations and experiments.
Cation Electrochemical Stability in Chloroaluminate Ionic Liquids (2005)

The electrochemical stability of 10 organic cations, which can be used in ionic liquids (IL), was investigated as solutes in acetonitrile (ACN). The stability of three of the salts, BenMe2EtNCl (salt III), 1-butyl-2-methyl pyrrolidium chloride (salt VI), and its structural isomer, BuMe2ProNCl (salt VII), were also compared in chloroaluminate ILs. The chloroaluminate ILs of salts VI and VII are investigated for the first time. The NaCl-neutralized ILs of salts VI and VII have melting points of 43.2 and 3.7 degrees C, respectively. The benzyl-substituted cation, salt III, was more easily reduced in ACN or as the neutral chloroaluminate IL than the alkyl-substituted cation, salt VII, due to the better leaving ability of the benzyl group. Mass spectroscopy measurements before and after electrolysis on the benzyl-substituted solutions confirmed that reduction involves the loss of an alkyl group. In ACN, salt VI was found to be the most difficult to reduce (1 mA/cm2 at -2.09 V) due to its cyclic structure. However, in the chloroaluminate IL, the pyrrolidinium cation was more easily reduced than salt III or its isomer, salt VII, resulting in an insoluble black deposit. This is consistent with the mass spectrometry data, which do not show formation of low-molecular-weight products, as in the reduction of salts III and VII. The IL of salt VII was the most stable in the presence of sodium. Sodium ions could be reduced and reoxidized with a maximum Coulombic efficiency of 94.1% versus 87.2% for salt VI. Reduction of the pyrrolidinium cation produces insoluble products, most likely through opening of the cyclic ring, and an inferior medium for sodium ion reduction compared to the benzyl- and butyl-substituted cations, even though reduction of the cation occurs at a more negative potential in acetonitrile.
[Coronary reoperation: indications, methods and immediate postoperative prognosis. Retrospective study of 184 reoperations]. (1998)

The authors performed 184 coronary reoperations (172 redux, 12 tridux) between January 1986 and december 1995 in 177 patients (165 men, 12 women) with an average age at surgery of 62.9 +/- 7.6 years. The average interval between the surgical procedures was 9.5 +/- 4.5 years. The symptoms were recurrent angina, stable in 44%, unstable in 51%, and cardiac failure, 7%. Graft dysfunction was the cause in 94.5% of cases with progression of atheroma of the native coronary vessels in only 5.6% of cases. At reoperation 389 bypass procedures were performed (venous 39.5%, arterial 60.5%) (2.1 +/- 0.6 per patient) with 10 associated procedures (3 mitral valvuloplasties, 2 left ventricular aneurysmectomy, 3 aortic valve replacements, 1 replacement of the ascending aorta, 1 carotid endarteriectomy). The operative mortality was 10.9%. The causes of the 20 deaths were myocardial infarction (7), left ventricular failure (8), arrhythmias (2), mediastinitis (1) and multi-organ failure (2). The risk factors for death were: the date of surgery (19% before 1991 and 8% after: p = 0.03), age (18% after 60 years, 2% before: p = 0.015), the interval between the surgical procedures (33% after 15 years, p = 0.02), anterograde cardioplegic injection alone (15% versus 4.5% when mixed antero and retrograde perfusion was used: p = 0.02). The morbidity was 28% (52/184 patients); 132 patients (72%) had uncomplicated postoperative courses. The incidence of repeat coronary artery surgery is in constant progression. Improved medico-surgical management should continue to reduce the mortality which is still high.
YESS 2.0, a Tunable Platform for Enzyme Evolution, Yields Highly Active TEV Protease Variants (2021)

Here we describe YESS 2.0, a highly versatile version of the yeast endoplasmic sequestration screening (YESS) system suitable for engineering and characterizing protein/peptide modifying enzymes such as proteases with desired new activities. By incorporating features that modulate gene transcription as well as substrate and enzyme spatial sequestration, YESS 2.0 achieves a significantly higher operational and dynamic range compared with the original YESS. To showcase the new advantages of YESS 2.0, we improved an already efficient TEV protease variant (TEV-EAV) to obtain a variant (eTEV) with a 2.25-fold higher catalytic efficiency, derived almost entirely from an increase in turnover rate (<i>k</i><sub>cat</sub>). In our analysis, eTEV specifically digests a fusion protein in 2 h at a low 1:200 enzyme to substrate ratio. Structural modeling indicates that the increase in catalytic efficiency of eTEV is likely due to an enhanced interaction between the catalytic Cys151 with the P1 substrate residue (Gln). Furthermore, the modeling showed that the ENLYFQS peptide substrate is buried to a larger extent in the active site of eTEV compared with WT TEV. The new eTEV variant is functionally the fastest TEV variant reported to date and could potentially improve efficiency in any TEV application.
Force microscopy imaging in liquids using ac techniques (1994)

Two ac techniques for imaging under liquids using atomic force microscopy are investigated. In the first method, the sample is oscillated with a sinusoidal displacement, whereas in the second method, the cantilever is oscillated with a sinusoidal magnetic force. Both techniques are successful for topographic imaging under liquids with the tip in repulsive contact with the sample. Of the two methods, the cantilever driven technique is found to be less noisy. In addition to topographic imaging, noncontact magnetic force imaging under liquid is demonstrated.
STAT3 regulation of and by microRNAs in development and disease (2012)

MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs acting at the post-transcriptional level where they promote mRNA degradation and block protein translation. Recent findings suggest that complex transcriptional and post-transcriptional circuits control miRNAs. STAT3 has emerged as an important regulator of their expression and biogenesis and, in turn, STAT3 signaling pathways are controlled by distinct miRNAs. We summarize the current knowledge on STAT3 mediated processing of individual miRNAs and contrariwise, the modulation of the STAT3 pathway by miRNAs in development and in pathophysiological conditions such as immune processes, infection, cancer, cardiovascular disease and pulmonary hypertension.
The Atacama Cosmology Telescope: cosmological parameters from three seasons of data (2013)

We present constraints on cosmological and astrophysical parameters from high-resolution microwave background maps at 148 GHz and 218 GHz made by the Atacama Cosmology Telescope (ACT) in three seasons of observations from 2008 to 2010. A model of primary cosmological and secondary foreground parameters is fit to the map power spectra and lensing deflection power spectrum, including contributions from both the thermal Sunyaev-Zeldovich (tSZ) effect and the kinematic Sunyaev-Zeldovich (kSZ) effect, Poisson and correlated anisotropy from unresolved infrared sources, radio sources, and the correlation between the tSZ effect and infrared sources. The power ℓ2<em>C</em>ℓ/2π of the thermal SZ power spectrum at 148 GHz is measured to be3.4±1.4 μK2 at ℓ = 3000, while the corresponding amplitude of the kinematic SZ power spectrum has a 95% confidence level upper limit of 8.6 μK2. Combining ACT power spectra with the WMAP 7-year temperature and polarization power spectra, we find excellent consistency with the LCDM model. We constrain the number of effective relativistic degrees of freedom in the early universe to be <em>N</em>eff = 2.79±0.56, in agreement with the canonical value of <em>N</em>eff = 3.046 for three massless neutrinos. We constrain the sum of the neutrino masses to be Σ<em>m</em>ν &lt; 0.39 eV at 95% confidence when combining ACT and WMAP 7-year data with BAO and Hubble constant measurements. We constrain the amount of primordial helium to be <em>Y</em><em>p</em> = 0.225±0.034, and measure no variation in the fine structure constant α since recombination, withα/α0 = 1.004±0.005. We also find no evidence for any running of the scalar spectral index, <em>dn</em><em>s</em>/<em>d</em>ln <em>k</em> = −0.004±0.012.
Electrically pumped laser transmitter integrated on thin-film lithium niobate (2022)

Integrated thin-film lithium niobate (TFLN) photonics has emerged as a promising platform for the realization of high-performance chip-scale optical systems. Of particular importance are TFLN electro-optic modulators featuring high-linearity, low driving voltage and low propagation loss. However, a fully integrated system requires integration of high power, low noise, and narrow linewidth lasers on TFLN chips. Here we achieve this goal, and demonstrate integrated high-power lasers on TFLN platform with up to 60 mW of optical power in the waveguides. We use this platform to realize a high-power transmitter consisting of an electrically pumped laser integrated with a 50 GHz modulator.
Analytical processing of XML documents (2005)

Online Analytical Processing (OLAP) has been a valuable tool for analyzing trends in business information. While the multi-dimensional cube model used by OLAP is ideal for analyzing structured business data, it is not suitable for representing and analyzing complex semi-structured data, such as, XML documents. Need for analyzing XML documents is gaining urgency as XML has become the language of choice for data representation across a wide range of application domains. This paper describes a proposal for analyzing XML documents using the abstract XML tree model. We argue that OLAP's multi-dimensional aggregation operators can not express structurally complex analytical operations on XML documents. Hence, we outline new extensions to XQuery for supporting such complex analytical operations. Finally, we discuss various challenges in implementing XML analysis in a real system.
Photocontrol over Cooperative Porphyrin Self‐Assembly with Phenylazopyridine Ligands (2012)

Die kooperative Selbstorganisation chiraler Zinkporphyrine wird durch einen photoresponsiven Phenylazopyridin-Ligand (1) gesteuert. Die Porphyrinstapel depolymerisieren zu Dimeren, wenn dieser Ligand in axialer Stellung koordiniert, und die Stärke dieser Koordination wird durch die photoinduzierte Isomerisierung des Liganden kontrolliert, bei der für beide Zustände Umsatzverhältnisse über 95 % erzielt werden. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Supplementary Figures 1 - 3, Table 1 from Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia (2023)

&lt;p&gt;Supplementary Figure 1. Anti-CD3 stimulation of primary human T-ALLs. Supplementary Figure 2. TCR stimulation by in vivo administration of agonistic monoclonal antibody in a preventive setting inhibits human TCR+ T-ALL development. Supplementary Figure 3. TCR signaling is essential to the anti-leukemic effect of OKT3. Supplementary Table 1. Immunophenotypic and oncogenic characteristics of T-ALL samples.&lt;/p&gt;
Multiple energy-scales in vertex-frustrated mesospin systems (2021)

The interplay between topology and energy-hierarchy plays a vital role in the collective magnetic order in artificial ferroic systems. Here we investigate, experimentally, the effect of having one or two activation energies of interacting Ising-like magnetic islands -- mesospins -- in thermalized, vertex-frustrated lattices. The thermally arrested magnetic states of the elements were determined using synchrotron-based magnetic microscopy after cooling the samples from temperatures above the Curie temperature of the material. Statistical analysis of the correlations between mesospins across several length-scales, reveals changes in the magnetic order, reflecting the amount of ground state plaquettes realized for a vertex-frustrated lattice. We show that the latter depends on the presence, or not, of different activation energies.