gebhart/patrepeval huggingface dataset:
Tenascin-C expression by fibroblasts is elevated in stressed collagen gels. (1994)

Chick embryo fibroblasts cultured on a collagen matrix exert tractional forces leading to the contraction of unrestrained, floating collagen gels and to the development of tension in attached, restrained gels. On a restrained, attached collagen gel the fibroblasts synthesize large quantities of tenascin-C, whereas in a floating, contracting gel tenascin-C synthesis is decreased. This regulation of tenascin-C synthesis can be observed by the secretion of metabolically labeled tenascin-C into the conditioned medium, as well as by the deposition of tenascin-C into the collagen matrix as judged by immunofluorescence. Regulation appears to occur at the transcriptional level, because when cells on attached or floating collagen gels are transfected with promoter constructs of the tenascin-C gene, luciferase expression driven by the tenascin-C promoter parallels the effects measured for endogenous tenascin-C synthesis, whereas luciferase expression under the control of the SV40 promoter does not depend on the state of the collagen gel. The promoter region responsible for tenascin-C induction on attached collagen gels is distinct from the region important for the induction of tenascin-C by serum, and may define a novel kind of response element. By joining this tenascin-C sequence to the SV40 promoter of a reporter plasmid, its activity can be transferred to the heterologous promoter. We propose that the tenascin-C promoter is directly or indirectly activated in fibroblasts generating and experiencing mechanical stress within a restrained collagen matrix. This may be an important aspect of the regulation of tenascin-C expression during embryogenesis as well as during wound healing and other regenerative and morphogenetic processes.
New Perfluoroarylborane Activators for Single-Site Olefin Polymerization. Acidity and Cocatalytic Properties of a “Superacidic” Perfluorodiboraanthracene (2002)

The synthesis, Lewis acid properties, and single-site olefin polymerization characteristics of catalyst systems utilizing the binuclear organo-Lewis acid cocatalyst 9,10-bis(pentafluorophenyl)-9,10-diboraoctafluoroanthracene, C12F8B2(C6F5)2 (8b), are reported. X-ray diffraction analysis of 8b reveals a nearly planar C12F8B2 core with −C6F5 rings rotated 75° out of the plane, hindering π communication between the pendant −C6F5 substituents and the C12F8B2 core, and thereby enhancing Lewis acidity at the boron centers. Competition equilibration experiments with 8b, B(C6F5)3, and acetonitrile over a wide temperature range demonstrate that 8b is a stronger Lewis acid than B(C6F5)3 by ΔH = +1.4(2) kcal/mol and ΔS = −5.3(1) eu. The diffraction-derived molecular structure of 8b←NCCH3 reveals substantial skeletal reorganization only at the coordinated boron center. When it is paired with dimethyl organo-group 4 catalyst precursors, 8b affords extremely efficient single-site olefin polymerization systems in both laboratory and large-scale reactors. In all cases, 8b forms polymerization systems with higher activities than those utilizing B(C6F5)3 as the cocatalyst.
Problems of Liberalization and the Succession at the Eighth Party Congress Roderick MacFarquhar (1973)

The eighth Congress of the Chinese Communist Party (CCP) met on 15 September 1956 in an atmosphere of some triumph. In the 11 years that had elapsed since the seventh Congress, the Communists had defeated the Kuomintang, taken over the country and set up a strong administration that had given the country the peace and unity so desperately lacking over the previous century. They had restored and developed the economy, substantially collectivized agriculture – without the drastic consequences suffered by the Soviet Union – and they had nationalized or semi-nationalized private industry and commerce. The People's Liberation Army had fought impressively in Korea, engendering a healthy respect abroad for the new Chinese regime. More recently, especially since the 1955 Bandung Conference, Chinese diplomacy had won new friends in Asia. China had stood up, Mao had said in 1949, and by 1956 it was clear to all that it had.
Etude de la morphologie interne des chars intumescents issus des tests au feu par la tomographie aux rayons X et des analyses numériques. (2017)

National audience
Negative Pressure Wound Therapy in Maxillofacial Applications (2016)

Negative pressure wound therapy has greatly advanced the field of wound healing for nearly two decades, by providing a robust surgical adjunct technique for accelerating wound closure in acute and chronic wounds. However, the application of negative pressure wound therapy in maxillofacial applications has been relatively under utilized as a result of the physical articulations and contours of the head and neck that make it challenging to obtain an airtight seal for different negative pressure wound therapy systems. Adapting negative pressure wound therapies for maxillofacial applications could yield significant enhancement of wound closure in maxillofacial applications. The current review summarizes the basic science underlying negative pressure wound therapy, as well as specific maxillofacial procedures that could benefit from negative pressure wound therapy.
Automated electric utility pole detection from aerial images (2009)

This paper presents an algorithm for the recognition of similar electrical poles from an aerial image by detecting the pole shadow. One pole is used as a template (already identified by a human operator) for the algorithm. The algorithm includes feature extraction, candidate position determination, and elimination of redundant candidates. First, features of a pole shadow are extracted using standard filters and image processing techniques. Then the extracted features are used to design convolution filters tailored to emphasize possible locations for the shadows. Subsequently, an image candidate is submitted to radon transformation to verify adherence to expected shadow characteristics. Simulations show that most poles are made much more noticeable by the algorithm.
Evaluating Query Result Significance in Databases via Randomizations (2010)

Many sorts of structured data are commonly stored in a multi-relational format of interrelated tables. Under this relational model, exploratory data analysis can be done by using relational queries. As an example, in the Internet Movie Database (IMDb) a query can be used to check whether the average rank of action movies is higher than the average rank of drama movies.
Modulation of T cell function and survival by the tumor microenvironment (2023)

Cancer immunotherapy is shifting paradigms in cancer care. T cells are an indispensable component of an effective antitumor immunity and durable clinical responses. However, the complexity of the tumor microenvironment (TME), which consists of a wide range of cells that exert positive and negative effects on T cell function and survival, makes achieving robust and durable T cell responses difficult. Additionally, tumor biology, structural and architectural features, intratumoral nutrients and soluble factors, and metabolism impact the quality of the T cell response. We discuss the factors and interactions that modulate T cell function and survive in the TME that affect the overall quality of the antitumor immune response.
Modeling of photoconductive switch using spectral domain approach (1993)

This paper deals with the microwave modeling of photoconductive switches. We extend the Spectral Domain Approach (SDA) to the modeling of microwave discontinuities realised on lossy substrates, which is the case of photoconductive switches. We show that, when coupled to the Complex Frequency Concept, the 3D SDA leads to a realistic electrical model of gaps on a microstrip line whose substrate conductivity is modified by an optical signal.
Absence of Thrombospondin-2 Causes Age-Related Dilated Cardiomyopathy (2009)

TSP-2 expression in the heart protects against age-dependent dilated cardiomyopathy.
Packet Scheduling and Traffic Differentiation in Femtocell Environment (2011)

This paper proposes new scheduling algorithms for best effort (BE) traffic classification in business femtocell networks. The purpose of traffic classification is to provide differentiated services to BE users depending on their traffic classes, and the concept of traffic classification is called Inter User Best Effort (IUBE) in CDMA2000 1x Evolution Data Optimized (EVDO) standard. Traffic differentiation is achieved by introducing Grade of Service (GoS) as a quality of service (QoS) parameter into the scheduler's decision metric (DM). New scheduling algorithms are called QoS Round Robin (QoS-RR), QoS Proportionally Fair (QoS-PF), QoS maximum data rate control (DRC) (QoS-maxDRC), QoS average DRC (QoS-aveDRC), QoS exponent DRC (QoS-expDRC), QoS maxDRC-PF (QoS-maxDRC-PF). Two different femtocell throughput experiments are performed using real femtocell devices in order to collect real DRC values. The first experiment examines 4, 8, 12 and 16 IUBE users, while second experiment examines 4 IUBE + 2 Voice over IP (VoIP), 8 IUBE + 2 VoIP, 12 IUBE + 2 VoIP, 16 IUBE + 2 (VoIP) users. Average sector throughput, IUBE traffic differentiation, VoIP delay bound error values are investigated to compare the performance of the proposed scheduling algorithms. In conclusion, QoS-maxDRC-PF scheduler is proposed for business femtocell environment.
Co-cultivation and transcriptome sequencing of two co-existing fish pathogens Moritella viscosa and Aliivibrio wodanis (2015)

From expression profiling of the transcriptomes, it is evident that the presence of A. wodanis is altering the global gene expression of M. viscosa. Co-cultivation studies showed that A. wodanis is impeding the growth of M. viscosa, and that the inhibitorial effect is not contact-dependent.
The Adsorption of Nonionic Surfactants onto Stainless Steel Surfaces from Iso-Octane (2009)

The synthesis of nine, nonionic, fuel-soluble poly(isobutylene)-based surfactants, and an assessment of their ability to remove and prevent carbonaceous deposit build up on light-duty vehicle engine valves, is described. Surfactants with varying surfactant head group polarity and structure, and tail length, were assessed for their potential fuel surfactant efficacy by establishing their adsorption kinetics and adsorption isotherms, from iso-octane, onto stainless steel surfaces, using both solution depletion and ellipsometry measurements. Increasing head group polarity from a simple phenol group, by the inclusion of an amine group, increased the adsorption affinity and the maximum adsorbed amount. Inclusion of additional amine groups also increased them maximum adsorbed amount, albeit only marginally. Replacing N-Me groups by N-H groups also increased the adsorbed amounts. Surfactant adsorption was found to be independent of tail length and the maximum adsorbed amount corresponded more-or-less to the surface concentration of strong acid groups on the steel surface, as determined by a Boehm titration. Additionally, all the surfactants studied appeared to adsorb onto the steel surface “irreversibly.”
Phase Retrieval with Application to Optical Imaging (2014)

This review article provides a contemporary overview of phase retrieval in optical imaging, linking the relevant optical physics to the information processing methods and algorithms. Its purpose is to describe the current state of the art in this area, identify challenges, and suggest vision and areas where signal processing methods can have a large impact on optical imaging and on the world of imaging at large, with applications in a variety of fields ranging from biology and chemistry to physics and engineering.
Genealogical analyses of multiple loci of litostomatean ciliates (Protista, Ciliophora, Litostomatea) (2012)

The class Litostomatea is a highly diverse ciliate taxon comprising hundreds of free-living and endocommensal species. However, their traditional morphology-based classification conflicts with 18S rRNA gene phylogenies indicating (1) a deep bifurcation of the Litostomatea into Rhynchostomatia and Haptoria+Trichostomatia, and (2) body polarization and simplification of the oral apparatus as main evolutionary trends in the Litostomatea. To test whether 18S rRNA molecules provide a suitable proxy for litostomatean evolutionary history, we used eighteen new ITS1-5.8S rRNA-ITS2 region sequences from various free-living litostomatean orders. These single- and multiple-locus analyses are in agreement with previous 18S rRNA gene phylogenies, supporting that both 18S rRNA gene and ITS region sequences are effective tools for resolving phylogenetic relationships among the litostomateans. Despite insertions, deletions and mutational saturations in the ITS region, the present study shows that ITS1 and ITS2 molecules can be used to infer phylogenetic relationships not only at species level but also at higher taxonomic ranks when their secondary structure information is utilized to aid alignment.
Evaluation of Three-Coat Stucco Installations on Commercial Buildings (2011)

Three-coat stucco (Portland cement plaster) has been successfully used as an exterior finish and weather barrier on residential structures for over a hundred years. Residential stucco is considered a highly durable material with typical lifespans in the range of 50 to 75 years. The authors have noted that in the last 20 years three-coat stucco has been increasingly used on commercial building, including mid-rise and high rise buildings. This trend may be related to the competitive aspects of stucco as an exterior finish as well as the reluctance of some architects to design with EIFS (synthetic stucco). However the performance of the stucco on commercial buildings has been, in the author's experience, rather mixed. The authors have investigated a number of commercial buildings where significant water intrusion problems have been related to the design and application of the stucco system. This paper presents a summary of problems we have observed with stucco performance on commercial buildings and explores the reasons for the difference in performance between residential and commercial stucco applications. We also make suggestions for improved stucco performance on commercial buildings.
Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1. (1992)

Loss of normal functions and gain of oncogenic functions when the p53 tumor suppressor gene is mutated are considered critical events in the development of the majority of human cancers. Human bronchial epithelial cells (BEAS-2B) provide an in vitro model system to study growth, differentiation, and neoplastic transformation of progenitor cells of lung carcinoma. When wild-type (WT) or mutant (MT; codon 143Val-Ala) human p53 cDNA was transfected into nontumorigenic BEAS-2B cells, we observed that (i) transfected WT p53 suppresses and MT p53 enhances the colony-forming efficiency of these cells, (ii) MT p53 increases resistance to transforming growth factor beta 1, and (iii) clones of MT p53 transfected BEAS-2B cells are tumorigenic when inoculated into athymic nude mice. These results are consistent with the hypothesis that certain mutations in p53 may function in multistage lung carcinogenesis by reducing the responsiveness of bronchial epithelial cells to negative growth factors.
Solution-processed high-LUMO-level polymers inn-type organic field-effect transistors: a comparative study as a semiconducting layer, dielectric layer, or charge injection layer (2015)

In solution-processed organic field-effect transistors (OFETs), the polymers with high level of lowest unoccupied molecular orbitals (LUMOs, > −3.5 eV) are especially susceptible to electron-trapping that causes low electron mobility and strong instability in successive operation. However, the role of high-LUMO-level polymers could be different depending on their locations relative to the semiconductor/insulator interface, or could even possibly benefit the device in some cases. We constructed unconventional polymer heterojunction n-type OFETs to control the location of the same polymer with a high LUMO level, to be in, under, or above the accumulation channel. We found that although the devices with the polymer in the channel suffer from dramatic instability, the same polymer causes much less instability when it acts as a dielectric modification layer or charge injection layer. Especially, it may even improve the device performance in the latter case. This result helps to improve our understanding of the electron-trapping and explore the value of these polymers in OFETs.
Mask quality assurance in cleaning for haze elimination using flexible mask specifications (2007)

We propose a new method of quality assurance for attenuated phase shifting mask (PSM) using the concept of the flexible mask specifications to extend the life of PSM [1]. The haze on PSM is a major issue for ArF lithography in semiconductor device manufacturing since it causes decline of device yield. PSM irradiated by ArF laser is periodically cleaned before haze is printed on wafer, which is a killer defect. Repetition of cleaning causes great changes of properties, i.e. phase, transmittance. Therefore, the number of times cleaning is performed has been limited by predetermined specifications based on ITRS. In this paper, relaxation of the pass/ fail criteria are studied as one solution to this limitation problem. In order to decide a suitable number of times for cleaning to be performed, we introduce the concept of flexible mask specifications, taking lithography margin into account. Firstly, we obtained mask parameters before cleaning; these parameters were, for instance, phase, transmittance and CD. Secondly, using these parameters, we simulated images of resist pattern exposed on wafer and obtained exposure latitude at desired depth of focus. Thirdly, we simulated mask parameters and exposure latitude when the mask was cleaned several times and obtained correlation between number of times cleaning is performed and exposure latitude. And finally, we estimated suitable pass/ fail criteria of mask parameters and the maximum number of times cleaning should be performed for each mask at the standard exposure latitude. In the above procedure, the maximum number of times cleaning should be performed exceeded that determined in the case of conventional specifications based on ITRS.
A brain-specific chemokine, FAM19A5, inhibits RANKL-induced osteoclast formation (2017)

Abstract Since osteoclast plays a key role in bone resorption, the identification of novel molecules that regulate osteoclastogenesis has been important issue. A neurokine or brain-specific chemokine, FAM19A5, a member of C-C chemokine family, is mainly expressed in central nervous system. In this study, we found that FAM19A5 strongly stimulated chemotactic migration of mouse bone marrow-derived macrophages (BMDM). FAM19A5 also markedly stimulated the activation of protein kinase B (Akt) and ERK, resulting in phosphorylation of the kinases in BMDM. FAM19A5 also blocks RANKL-induced osteoclastogenesis. It was confirmed by tartrate-resistant acid phosphatase (TRAP) staining and osteoclast-related gene level. Collectively, we suggest that FAM19A5 can act as a new ligand that regulates chemotactic migration of BMDM and osteoclastogenesis.
PaIntDB: network-based omics integration and visualization using protein–protein interactions in Pseudomonas aeruginosa (2021)

Supplementary data are available at Bioinformatics online.
Quantitative measurements of intraocular structures and microinjection bleb volumes using intraoperative optical coherence tomography (2022)

Intraoperative optical coherence tomography (OCT) systems provide high-resolution, real-time visualization and/or guidance of microsurgical procedures. While the use of intraoperative OCT in ophthalmology has significantly improved qualitative visualization of surgical procedures inside the eye, new surgical techniques to deliver therapeutics have highlighted the lack of quantitative information available with current-generation intraoperative systems. Indirect viewing systems used for retinal surgeries introduce distortions into the resulting OCT images, making it particularly challenging to make calibrated quantitative measurements. Using an intraoperative OCT system based in part on the Leica Enfocus surgical microscope interface, we have devised novel measurement procedures, which allowed us to build optical and mathematical models to perform validation of quantitative measurements of intraocular structures for intraoperative OCT. These procedures optimize a complete optical model of the sample arm including the OCT scanner, viewing attachments, and the patient's eye, thus obtaining the voxel pitch throughout an OCT volume and performing quantitative measurements of the dimensions of imaged objects within the operative field. We performed initial validation by measuring objects of known size in a controlled eye phantom as well as <i>ex vivo</i> porcine eyes. The technique was then extended to measure other objects and structures in <i>ex vivo</i> porcine eyes and <i>in vivo</i> human eyes.
Minimization of Ion–Solvent Clusters in Gel Electrolytes Containing Graphene Oxide Quantum Dots for Lithium‐Ion Batteries (2018)

This study uses graphene oxide quantum dots (GOQDs) to enhance the Li<sup>+</sup> -ion mobility of a gel polymer electrolyte (GPE) for lithium-ion batteries (LIBs). The GPE comprises a framework of poly(acrylonitrile-co-vinylacetate) blended with poly(methyl methacrylate) and a salt LiPF<sub>6</sub> solvated in carbonate solvents. The GOQDs, which function as acceptors, are small (3-11 nm) and well dispersed in the polymer framework. The GOQDs suppress the formation of ion-solvent clusters and immobilize PF6- anions, affording the GPE a high ionic conductivity and a high Li<sup>+</sup> -ion transference number (0.77). When assembled into Li|electrolyte|LiFePO<sub>4</sub> batteries, the GPEs containing GOQDs preserve the battery capacity at high rates (up to 20 C) and exhibit 100% capacity retention after 500 charge-discharge cycles. Smaller GOQDs are more effective in GPE performance enhancement because of the higher dispersion of QDs. The minimization of both the ion-solvent clusters and degree of Li<sup>+</sup> -ion solvation in the GPEs with GOQDs results in even plating and stripping of the Li-metal anode; therefore, Li dendrite formation is suppressed during battery operation. This study demonstrates a strategy of using small GOQDs with tunable properties to effectively modulate ion-solvent coordination in GPEs and thus improve the performance and lifespan of LIBs.
Novel one-step synthesis of amine-stabilized aqueous colloidal gold nanoparticlesElectronic supplementary information (ESI) available: FTIR, TEM, UV-vis and XRD results. See http://www.rsc.org/suppdata/jm/b4/b402823f/ (2004)

We demonstrate a simple one-step process for the synthesis of water-dispersed spherical gold nanoparticles using the multifunctional molecule oleyl amine (OLA) that electrostatically complexes with aqueous chloroaurate ions, reduces them, and subsequently caps the nanoparticles thus formed. The gold particles thus formed were of the fcc phase and were fairly monodisperse with particular concentrations of capping molecules.