gebhart/patrepeval huggingface dataset:
Low complexity resource allocation with opportunistic feedback over downlink OFDMA networks (2008)

Optimal tone allocation in downlink OFDMA networks is a non-convex NP-hard problem that requires extensive feedback for channel information. In this paper, two constant complexity limited-feedback algorithms are proposed to achieve near-optimal performance. First, using opportunistic feedback, the proposed schemes are shown to reduce feedback overhead by requiring only users likely to be allocated resources to feedback. There are differences between the two proposed schemes for implementation of the feedback protocol. One scheme requires less feedback but is contention-based, while the other scheme is sequential and thus avoids possible collisions leading to slightly higher performance, but needs more feedback. Second, complexity is reduced for resource allocation by solving the optimization problem in a distributed manner, rather than centrally at the base station. As shown both analytically and through numerical results, these distributed algorithms reduce the required feedback overhead significantly, and achieve constant computational complexity with little performance loss compared to the optimal solution.
Synthetic Study of Tetramethyljulolidine — A Key Intermediate Toward the Synthesis of the Red Dopant DCJTB for OLED Applications. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
A protocol for urine collection and storage prior to DNA methylation analysis (2018)

Addition of EDTA offers an inexpensive preserving agent for urine storage at RT up to seven days allowing for reliable hmDNA analysis. To avoid bacterial overgrowth PenStrep can be added without negatively affecting DNA preservation.
Nitrogen and boron spin-lattice relaxation in borazole (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitrogen and boron spin-lattice relaxation in borazoleGeorge M. Whitesides, Steven L. Regen, John B. Lisle, and Robert MaysCite this: J. Phys. Chem. 1972, 76, 20, 2871–2877Publication Date (Print):September 1, 1972Publication History Published online1 May 2002Published inissue 1 September 1972https://pubs.acs.org/doi/10.1021/j100664a015https://doi.org/10.1021/j100664a015research-articleACS PublicationsRequest reuse permissionsArticle Views50Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Thermal and Chemical Integrity of Ru Electrode in Cu/TaOx/Ru ReRAM Memory Cell (2019)

A good candidate for replacing the inert platinum (Pt) electrode in the well-behaved Cu/TaO x /Pt resistive RAM memory cell is ruthenium (Ru), already successfully deployed in the CMOS back end of line. We benchmark Cu/TaO x /Ru device against Cu/TaO x /Pt and investigate the impact of embedment of Cu/TaO x /Ru on two different substrates, Ti(20nm)/SiO 2 (730nm)/Si and Ti(20nm)/TaO x (30nm)/SiO 2 (730nm)/Si, on the cell's electrical performance. While the devices show similar switching performance at some operating conditions, there are notable differences at other operation regimes shedding light on the basic switching mechanisms and the role of the inert electrode. The critical switching voltages are significantly higher for Ru than for Pt devices and can be partly explained by the work function difference and different surface roughness of the inert electrode. The poorer switching properties of the Ru device are attributed to the degraded inertness properties of the Ru electrode as a stopping barrier for Cu + ions as compared to the Pt electrode. However, some of the degraded electrical properties of the Ru devices can be mitigated by an improved integration of the device on the Si wafer. This improvement is attributed to the suppression of crystallization of Ru and its silicidation reactions that take place at elevated local temperatures, present mainly during the reset operation. This hypothesis has been corroborated by extensive XRD studies of multiple layer systems annealed at temperatures between 300K and 1173K.
A Diverse Family of Proteins Containing Tumor Necrosis Factor Receptor-associated Factor Domains (2001)

We have identified three new tumor necrosis factor-receptor associated factor (TRAF) domain-containing proteins in humans using bioinformatics approaches, including: MUL, the product of the causative gene in Mulibrey Nanism syndrome; USP7 (HAUSP), an ubiquitin protease; and SPOP, a POZ domain-containing protein. Unlike classical TRAF family proteins involved in TNF family receptor (TNFR) signaling, the TRAF domains (TDs) of MUL, USP7, and SPOP are located near the NH(2) termini or central region of these proteins, rather than carboxyl end. MUL and USP7 are capable of binding in vitro via their TDs to all of the previously identified TRAF family proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, and TRAF6), whereas the TD of SPOP interacts weakly with TRAF1 and TRAF6 only. The TD of MUL also interacted with itself, whereas the TDs of USP7 and SPOP did not self-associate. Analysis of various MUL and USP7 mutants by transient transfection assays indicated that the TDs of these proteins are necessary and sufficient for suppressing NF-kappaB induction by TRAF2 and TRAF6 as well as certain TRAF-binding TNF family receptors. In contrast, the TD of SPOP did not inhibit NF-kappaB induction. Immunofluorescence confocal microscopy indicated that MUL localizes to cytosolic bodies, with targeting to these structures mediated by a RBCC tripartite domain within the MUL protein. USP7 localized predominantly to the nucleus, in a TD-dependent manner. Data base searches revealed multiple proteins containing TDs homologous to those found in MUL, USP7, and SPOP throughout eukaryotes, including yeast, protists, plants, invertebrates, and mammals, suggesting that this branch of the TD family arose from an ancient gene. We propose the moniker TEFs (TD-encompassing factors) for this large family of proteins.
Coupling between slow-waves and sharp-wave ripples organizes distributed neural activity during sleep in humans (2020)

Abstract Hippocampal-dependent memory consolidation during sleep is hypothesized to depend on the synchronization of distributed neuronal ensembles, organized by the hippocampal sharp-wave ripples (SWRs, 80-150 Hz) and subcortical/cortical slow-waves (0.5-4 Hz). However, the precise role of SWR-slow-wave interactions in synchronizing subcortical/cortical neuronal activity is unclear. Here, we leverage intracranial electrophysiological recordings from the human hippocampus, amygdala, temporal and frontal cortices, to examine activity modulation and cross-regional coordination during SWRs. Hippocampal SWRs are associated with widespread modulation of high frequency activity (HFA; 70-200 Hz) a measure of local neuronal activation. This peri-SWR HFA modulation is predicted by the coupling between hippocampal SWRs and local subcortical/cortical slow-waves. Finally, local cortical slow-wave phase offsets during SWRs predicted functional connectivity between the frontal and temporal cortex. These findings suggest a selection mechanism wherein hippocampal SWR and cortical slow-wave synchronization governs the transient engagement of distributed neuronal populations supporting hippocampal-dependent memory consolidation.
The administration of Fructus Schisandrae attenuates dexamethasone-induced muscle atrophy in mice (2015)

In the present study, we aimed to determine whether ethanol extracts of Fructus Schisandrae (FS), the dried fruit of Schizandra chinensis Baillon, mitigates the development of dexamethasone-induced muscle atrophy. Adult SPF/VAT outbred CrljOri:CD1 (ICR) mice were either treated with dexamethasone to induce muscle atrophy. Some mice were treated with various concentrations of FS or oxymetholone, a 17α-alkylated anabolic-androgenic steroid. Muscle thickness and weight, calf muscle strength, and serum creatine and creatine kinase (CK) levels were then measured. The administration of FS attenuated the decrease in calf thickness, gastrocnemius muscle thickness, muscle strength and weight, fiber diameter and serum lactate dehydrogenase levels in the gastrocnemius muscle bundles which was induced by dexamethasone in a dose-dependent manner. Treatment with FS also prevented the dexamethasone-induced increase in serum creatine and creatine kinase levels, histopathological muscle fiber microvacuolation and fibrosis, and the immunoreactivity of muscle fibers for nitrotyrosine, 4-hydroxynonenal, inducible nitric oxide synthase and myostatin. In addition, the destruction of the gastrocnemius antioxidant defense system was also inhibited by the administration of FS in a dose-dependent manner. FS downregulated the mRNA expression of atrogin-1 and muscle ring-finger protein-1 (involved in muscle protein degradation), myostatin (a potent negative regulator of muscle growth) and sirtuin 1 (a representative inhibitor of muscle regeneration), but upregulated the mRNA expression of phosphatidylinositol 3-kinase, Akt1, adenosine A1 receptor and transient receptor potential cation channel subfamily V member 4, involved in muscle growth and the activation of protein synthesis. The overall effects of treatment with 500 mg/kg FS were comparable to those observed following treatment with 50 mg/kg oxymetholone. The results from the present study support the hypothesis that FS has a favorable ameliorating effect on muscle atrophy induced by dexamethasone, by exerting anti-inflammatory and antioxidant effects on muscle fibers, which may be due to an increase in protein synthesis and a decrease in protein degradation.
Pulmonary Administration of the Liposome-Based Adjuvant CAF01: Effect of Surface Charge on Mucosal Adjuvant Function (2022)

Mucosal surfaces of the lungs represent a major site of entry for airborne pathogens, and pulmonary administration of vaccines is an attractive strategy to induce protective mucosal immunity in the airways. Recently, we demonstrated the potential of pulmonary vaccination with the tuberculosis subunit antigen H56 adjuvanted with the cationic liposomal adjuvant formulation CAF01, which consists of the cationic lipid dimethyldioctadecylammonium (DDA) bromide and the synthetic cord factor trehalose-6,6'-dibehenate. However, the cationic charge of DDA represents a major safety challenge. Hence, replacing DDA with a safer zwitterionic or anionic phospholipid is an attractive approach to improve vaccine safety, but the effect of liposomal surface charge on the induction of mucosal immunity after airway immunization is poorly understood. Here, we investigated the effect of surface charge by replacing the cationic DDA component of CAF01 with zwitterionic dipalmitoylphosphatidylcholine (DPPC) or anionic dipalmitoylphosphatidylglycerol (DPPG), and we show that charge modification enhances antigen-specific pulmonary T-cell responses against co-formulated H56. We systematically replaced DDA with either DPPC or DPPG and found that these modifications resulted in colloidally stable liposomes that have similar size and morphology to unmodified CAF01. DPPC- or DPPG-modified CAF01 displayed surface charge-dependent protein adsorption and induced slightly higher follicular helper T cells and germinal center B cells in the lung-draining lymph nodes than unmodified CAF01. In addition, modified CAF01 induced significantly higher levels of H56-specific Th17 cells and polyfunctional CD4<sup>+</sup> T cells in the lungs, as compared to unmodified CAF01. However, the strong H56-specific humoral responses induced by CAF01 in the lungs and spleen were not influenced by surface charge. Hence, these results provide insights into the importance of surface charge for liposomal adjuvant function and can also guide the design of safe pulmonary subunit vaccines against other mucosal pathogens.
Pseudohermaphroditism, Glomerulopathy, and Wilms’ Tumor (Drash Syndrome): Frequency in End-Stage Renal Failure (1985)

No AccessJournal of Urology1 Oct 1985Pseudohermaphroditism, Glomerulopathy, and Wilms’ Tumor (Drash Syndrome): Frequency in End-Stage Renal Failure A.A. Eddy and S.M. Mauer A.A. EddyA.A. Eddy More articles by this author and S.M. MauerS.M. Mauer More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)47472-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Pseudohermaphroditism, Glomerulopathy, and Wilms’ Tumor (Drash Syndrome): Frequency in End-Stage Renal Failure." The Journal of Urology, 134(4), p. 844 © 1985 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 134Issue 4October 1985Page: 844 Advertisement Copyright & Permissions© 1985 by The American Urological Association Education and Research, Inc.MetricsAuthor Information A.A. Eddy More articles by this author S.M. Mauer More articles by this author Expand All Advertisement PDF downloadLoading ...
Presensitizing with a Toll-like receptor 3 ligand impairs CD8 T-cell effector differentiation and IL-33 responsiveness (2012)

The synthetic double-stranded RNA poly(I:C) is commonly used as an adjuvant to boost CD8 T-cell function; however, polyinosinic:polycytidylic acid [poly(I:C)] can also suppress autoimmune disease. The mechanism by which a single adjuvant achieves two distinct immunoregulatory roles is unknown. Although it is clear that coadministration of poly(I:C) with antigen elicits strong adjuvant effects in mice, we found that poly(I:C) injection before antigen substantially reduced antigen-dependent CD8 T-cell responses. Notably, CD8 T cells sensitized in poly(I:C)-pretreated mice failed to fully up-regulate IL-33R (ST2), which led to impaired T-cell receptor-independent responses to IL-33. In contrast, nonsensitized effector CD8 T cells responded robustly to IL-33 using a two-signal cytokine mechanism. During an acute lung response to Staphylococcus aureus enterotoxin, peripheral injection of poly(I:C) manifested a suppressive process by inhibiting the differentiation of both antigen- and IL-33-responsive CD8 effectors systemically. These findings highlight that early exposure to double-stranded RNA reverses its role as an adjuvant and, importantly, prevents IL-33R up-regulation on CD8 effector T cells to dampen inflammation.
In Situ Observation of Degradation by Ligand Substitution in Small-Molecule Phosphorescent Organic Light-Emitting Diodes (2014)

Solutions of facial-tris(1-phenylpyrazole)Ir(III) (fac-Ir(ppz)3), when dissolved in either tert-butyl isocyanide or in solid films of 2-naphthylisocyanide, undergo replacement of a ppz ligand by the isocyanide molecules after irradiation with UV light as demonstrated by liquid chromatograph mass spectrometer analysis. Similarly, solutions of Ir(ppz)3 and bathophenanthroline (BPhen) in CH2Cl2 or acetone-d6 form a brightly emissive species, [Ir(ppz)2(Bphen)]+ when irradiated with UV light as established by optical, mass, and 1H nuclear magnetic resonance spectroscopy. Electroluminescent data from blocked organic light-emitting diode (OLED) devices demonstrate that both mer- and fac-(Ir(ppz)3) dissociate a ligand and coordinate a neighboring BPhen molecule when the device is operated at moderate to high current levels. These experiments offer direct evidence of the dissociation of a metal–ligand bond and subsequent ligand substitution as a degradation pathway in active OLED devices during operation and provide a route to assay in situ the stability of future dopants.
Expansion of guidance for the day 8 initiation dose of paliperidone palmitate to avoid a missed dose (2013)

These simulations indicate that using the expanded dosing window of ±4 days has little effect on paliperidone exposure. A review of the overall pattern of treatment-emergent adverse events did not identify any new safety risks associated with the expanded dosing window.
Effects of shell thickness on the electric field dependence of exciton recombination in CdSe/CdS core/shell quantum dots (2017)

Here we examine the effects of shell thickness on the photophysical properties of CdSe/CdS core/shell quantum dots (QDs) in an electric field. Photoluminescence (PL) of QDs in an applied electric field is observed to decrease markedly with increasing shell thickness, with a thick-shelled (4.9 nm shell) sample exhibiting an order of magnitude greater PL suppression than a thin-shelled sample (1.25 nm shell) with the same core.
The Surface Ultrastructure of Gaucher Cells (1979)

The Gaucher cells of seven patients with Gaucher's disease were examined by both transmission and scanning electron microscopy. The ultrastructure of the cells, as seen by transmission electron microscopy, did not differ from that reported in the literature. The surface structure varied not only in the different patients but also in the same individual. The cells were oval or round, most of them with a rough surface due to presence of microvilli, ruffles, ridges, and blebs of various numbers and shapes. In two patients the Gaucher cells showed phagocytosis. The appearance of the surface ultrastructure of the Gaucher cells supports the accepted view that they are related to the cells of the reticuloendothelial system.
Multiwatt KTiOPO 4 optical parametric oscillators pumped within randomly and linearly polarized Nd:YAG laser cavities (2000)

We present 2 experiments on intracavity pumping of a KTiOPO<SUB>4</SUB> (KTP) optical parametric oscillator (OPO) within a high power 1064nm Nd:YAG laser cavity producing multiwatt level 2-micron outputs. In such high power regime, the Nd:YAG rod laser suffers significant thermally-induced birefringence loss when it is linearly polarized. Hence in the first experiment, we present our intracavity KTP OPO pumped within the simple cavity of an unpolarized Nd:YAG laser. This simple configuration, with 1-micron high reflectors forming the Nd:YAG laser cavity and R equals 75 percent and 100 percent 2-micron mirrors forming the short flat-flat OPO cavity, delivered 6.5W of 2-micron output power at 3kHz Q-switched operation. Next we pumped our intracavity OPO within a more complex polarized Nd:YAG laser cavity. In this second experiment, we compensated for the thermally-induced birefringence loss in the Nd:YAG laser by using a re-entrant laser cavity with a Faraday rotator, and the OPO was pumped within one arm of this set-up. In this case, we also obtained approximately 6.5W of 2-micron output. FInally, studies of the temporal profiles of the 1 and 2-micron laser beams also revealed interesting multiple pulse features in such intracavity OPO output.
Deoxyguanosine Phosphate Mediated Sacrificial Bonds Promote Synergistic Mechanical Properties in Nacre-Mimetic Nanocomposites (2013)

We show that functionalizing polymer-coated colloidal nanoplatelets with guanosine groups allows synergistic increase of mechanical properties in nacre-mimetic lamellar self-assemblies. Anionic montmorillonite (MTM) was first coated using cationic poly(diallyldimethylammonium chloride) (PDADMAC) to prepare core-shell colloidal platelets, and subsequently the remaining chloride counterions allowed exchange to functional anionic 2'-deoxyguanosine 5'-monophosphate (dGMP) counterions, containing hydrogen bonding donors and acceptors. The compositions were studied using elemental analysis, scanning and transmission electron microscopy, wide-angle X-ray scattering, and tensile testing. The lamellar spacing between the clays increases from 1.85 to 2.14 nm upon addition of the dGMP. Adding dGMP increases the elastic modulus, tensile strength, and strain 33.0%, 40.9%, and 5.6%, respectively, to 13.5 GPa, 67 MPa, and 1.24%, at 50% relative humidity. This leads to an improved toughness seen as a ca. 50% increase of the work-to-failure. This is noteworthy, as previously it has been observed that connecting the core-shell nanoclay platelets covalently or ionically leads to increase of the stiffness but to reduced strain. We suggest that the dynamic supramolecular bonds allow slippage and sacrificial bonds between the self-assembling nanoplatelets, thus promoting toughness, still providing dynamic interactions between the platelets.
Testis Cryopreservation for Future Autotransplantation: Comparison of Freezing Methods (2019)

Howards, Stuart S. MD, FACS; Ademoyero, Oludamilola MSc; Greene, Elizabeth D. LATG; Chen, Zhen; Atala, Anthony MD, FACS; Brockbank, Kelvin PhD; Sadri-Ardekani, Hooman MD, PhD Author Information
Adaptive Mechanisms in Cortical Networks Underlying Cortical Contributions to Learning and Nondeclarative Memory (1990)

The purpose of this paper is to summarize our research progress in studies of the dynamic mechanisms of the cerebral cortex underlying its contributions to learning and nondeclarative memory in experiments conducted over the past five years. Five years ago, we and other workers (see below) had discovered that the details of cortical representations could be altered by peripheral lesions in adult primates. Furthermore, we argued that the cortical representational reorganization in somatosensory (SI) cortical fields following peripheral nerve injuries did not merely reflect the existence of aberrantly sprouted connections (see Merrill and Wall 1978), but must manifest normal dynamic cortical processes by which the selective, distributed responses of cortical neurons—cortical “maps”—are shaped by our experiences throughout life (Merzenich et al. 1983b, 1984a,b; Merzenich 1986). We set out to confirm and extend preliminary behavioral/physiological experiments in somatosensory cortical area 3b that supported this conclusion; to determine how such distributed representational...
Linear and nonlinear identification of the carotid sinus baroreflex in the very low‐frequency range (2022)

Since the arterial baroreflex system is classified as an immediate control system, the focus has been on analyzing its dynamic characteristics in the frequency range between 0.01 and 1 Hz. Although the dynamic characteristics in the frequency range below 0.01 Hz are not expected to be large, actual experimental data are scant. The aim was to identify the dynamic characteristics of the carotid sinus baroreflex in the frequency range down to 0.001 Hz. The carotid sinus baroreceptor regions were isolated from the systemic circulation, and carotid sinus pressure (CSP) was changed every 10 s according to Gaussian white noise with a mean of 120 mmHg and standard deviation of 20 mmHg for 90 min in anesthetized Wistar-Kyoto rats (n = 8). The dynamic gain of the linear transfer function relating CSP to arterial pressure (AP) at 0.001 Hz tended to be greater than that at 0.01 Hz (1.060 ± 0.197 vs. 0.625 ± 0.067, p = 0.080), suggesting that baroreflex control was largely maintained at 0.001 Hz. Regarding nonlinear analysis, a second-order Uryson model predicted AP with a higher R<sup>2</sup> value (0.645 ± 0.053) than a linear model (R<sup>2</sup> = 0.543 ± 0.057, p = 0.025) or a second-order Volterra model (R<sup>2</sup> = 0.589 ± 0.055, p = 0.045) in testing data. These pieces of information may be used to create baroreflex models that can add a component of autonomic control to a cardiovascular digital twin for predicting acute hemodynamic responses to treatments and tailoring individual treatment strategies.