gebhart/patrepeval huggingface dataset:
Numerical Simulation of Swirl-Stabilized Premixed Flames With a Turbulent Combustion Model Based on a Systematically Reduced 6-Step Reaction Mechanism (2000)

This paper presents the application of a detailed combustion model for turbulent premixed combustion to a swirl-stabilized premix burner. Computations are carried out for atmospheric pressure and elevated pressure of 9 atm. Results of computations for atmospheric pressure are compared to experimental data. The combustion model is of the joint-pdf type. The model is based on the characteristics of turbulent combustion under conditions typical for gas turbine burners. It incorporates a systematically reduced 6-step reaction mechanism yielding direct computation of radical concentrations via transport equations or steady-state assumptions. The model is able to simulate combustion of fuel gases containing methane, carbon monoxide, hydrogen, carbon dioxide and water. It is therefore applicable to both methane and low-BTU fuel gas combustion. Based on computed radical concentrations, a post-processor for NOx-formation is applied. This post-processor considers thermal formation of nitrogen oxides and NO-formation via the nitrous-oxide path.
A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies (2018)

The antigenically conserved hemagglutinin stalk region is a target for universal influenza virus vaccines since antibodies against it can provide broad protection against influenza viruses of different subtypes. We tested a universal influenza virus vaccination regimen based on sequential immunization with chimeric hemagglutinin (HA) containing viruses in a swine influenza virus pig model with maternal antibodies against pandemic H1N1. Vaccines were administered as live attenuated virus or inactivated influenza virus split vaccine (+/- Emulsigen adjuvant). As controls, we included groups that received trivalent inactivated influenza vaccine that contained pandemic H1N1 antigens, inactivated adjuvanted H1N2 vaccine (control group for vaccine associated enhanced respiratory disease in the pig model) or mock-vaccination. No induction of H1 head or stalk-specific antibody responses was observed upon vaccination, while responses against H3 and influenza B HA were elicited in the group vaccinated with the trivalent vaccine. Four weeks post vaccination, pigs were intratracheally challenged with pandemic H1N1 virus and euthanized 5 days after challenge. Despite the lack of detectable anti-stalk immunity, the chimeric hemagglutinin vaccine resulted in better clinical outcomes compared to control groups.
Severe peripheral blood lymphopenia without NK cell cytotoxicty deficiency is the rule in adult acquired HLH (2015)

Hemophagocytic lymphohistiocytosis (HLH) is characterized by hypercytokinemia and hemophagocytosis due to abnormal activation and proliferation of T lymphocytes and macrophages. Inherited forms are due to gene defects affecting CD8 and NK lymphocyte cytotoxicity, whereas in acquired forms complicating rheumatic, infectious or neoplastic diseases, lymphocyte subpopulation and function profiles remain poorly studied.
CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer (2008)

Tumors that progress do so via their ability to escape the antitumor immune response through several mechanisms, including developing ways to induce the differentiation and/or recruitment of CD4(+)CD25(+) Tregs. The Tregs, in turn, inhibit the cytotoxic function of T cells and NK cells, but whether they have an effect on the cytotoxic function of tumor-infiltrating DCs (TIDCs) has not been determined. Here we have shown, in 2 rodent models of colon cancer, that CD4(+)CD25(+) Tregs inhibit the ability of CD11b(+) TIDCs to mediate TNF-related apoptosis-inducing ligand-induced (TRAIL-induced) tumor cell death. In both models of cancer, combination treatment with Mycobacterium bovis Bacillus Calmette-Guérin (BCG), which activates the innate immune system via TLR2, TLR4, and TLR9, and cyclophosphamide (CTX), which depletes Tregs, eradicated the tumors. Further analysis revealed that the treatment led to a marked increase in the number of CD11b(+) TIDCs that killed the tumor cells via a TRAIL-dependent mechanism. Furthermore, acquisition of TRAIL expression by the CD11b(+) TIDCs was induced by BCG and dependent on signaling through TLR2, TLR4, and TLR9. In vivo transfer of Tregs abrogated the ability of BCG to induce CD11b(+) TIDCs to express TRAIL and thereby nullified the efficacy of the CTX-BCG treatment. Our data have therefore delineated what we believe to be a novel mechanism by which Tregs inhibit the antitumor immune response.
Pose-Guided Human Parsing by an AND/OR Graph Using Pose-Context Features (2016)

Parsing human into semantic parts is crucial to human-centric analysis. In this paper, we propose a human parsing pipeline that uses pose cues, e.g., estimates of human joint locations, to provide pose-guided segment proposals for semantic parts. These segment proposals are ranked using standard appearance cues, deep-learned semantic feature, and a novel pose feature called pose-context. Then these proposals are selected and assembled using an And-Or graph to output a parse of the person. The And-Or graph is able to deal with large human appearance variability due to pose, choice of clothing, etc. We evaluate our approach on the popular Penn-Fudan pedestrian parsing dataset, showing that it significantly outperforms the state of the art, and perform diagnostics to demonstrate the effectiveness of different stages of our pipeline.
Answering questions in materials science using FIB/SEM dual beam methods (2007)

Extended abstract of a paper presented at MC 2007, 33rd DGE Conference in Saarbrücken, Germany, September 2 – September 7, 2007
On the Achievable Throughput of Multi-Band Multi-Antenna Wireless Mesh Networks (2008)

Recent technological advances have enabled SDRs to switch from one frequency to another at low cost, thus making dynamic multi-band access possible. On the other hand, recent advances in signal processing combined with those in antenna technology provide MIMO capabilities, thereby creating opportunities for enhancing the throughput of wireless networks. Both SDRs and MIMO together enable next-generation wireless networks, such as wireless mesh networks, to support dynamic and adaptive bandwidth sharing along time, frequency, and space. In this paper, we develop a new framework that identifies the limits and potentials of SDRs and MIMO. We characterize and analyze the maximum throughput that wireless networks can achieve when they are SDR-capable and MIMO-equipped.
In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates. (1992)

Aberrant signal transduction has been implicated in malignant transformation, growth, and progression. This has led to the proposal to use inhibitors of signal transduction pathways to treat cancer. One approach to circumventing potential toxicity and improving efficacy would be to target pathways upon which cancer cells selectively depend. Pathways associated with the malignant process involve calcium fluxes, the release of arachidonic acid, and the generation of phosphoinositides. In this report, CAI (L651582, NSC 609974), a substituted carboxyamido-imidazole and novel inhibitor of these selected signal transduction pathways, inhibits anchorage-dependent and -independent growth in a large series of human cancer cell lines. CAI pretreatment of HT-29 human colon cancer and 5R ras-transfected rat embryo fibroblast cells inhibits the formation and growth of experimental pulmonary metastases in nude mice. Oral administration of CAI in PEG-400 vehicle arrests growth and metastasis of transplanted human melanoma and ovarian cancer xenografts. No significant gross or histological toxicity was observed at CAI doses yielding blood levels in the concentration range demonstrated to inhibit select signal transduction pathways in vitro. These data indicate the feasibility and demonstrate a potential selectivity and sensitivity of using specific signal transduction inhibitors for the experimental treatment of cancer.
Conversion of 2,3-butanediol to butadiene (2023)

A composition comprising 2,3-butanediol is dehydrated to methyl vinyl carbinol and/or 1,3-butadiene by exposure to a catalyst comprising (a) M.sub.xO.sub.y wherein M is a rare earth metal, a group IIIA metal, Zr, or a combination thereof, and x and y are based upon an oxidation state of M, or (b) M.sup.3.sub.a(PO.sub.4).sub.b where M.sup.3 is a group IA, a group IIA metal, a group IIIA metal, or a combination thereof, and a and b are based upon the oxidation state of M.sup.3. Embodiments of the catalyst comprising M.sub.xO.sub.y may further include M.sup.2, wherein M.sup.2 is a rare earth metal, a group IIA metal, Zr, Al, or a combination thereof. In some embodiments, 2,3-butanediol is dehydrated to methyl vinyl carbinol and/or 1,3-butadiene by a catalyst comprising M.sub.xO.sub.y, and the methyl vinyl carbinol is subsequently dehydrated to 1,3-butadiene by exposure to a solid acid catalyst.
An Escherichia coli gene divergently transcribed from a promoter overlapping the metA promoter (2006)

The upstream region of the metA gene in Escherichia coli contains two promoters. We have identified by lacZ fusion an additional promoter in this region, and showed that it is transcribed in the opposite orientation from the metA gene. The putative translation product corresponds to a peptide of 147 amino acids-ORF19 by molecular mass. This peptide is probably not essential for growth, as an insertion mutant is viable.
Combined lithographies for the reduction of stitching errors in lithography (1994)

A new way of lithography is presented, which makes use of overlapping address fields to expose patterns by conventional or unconventional lithographies and uses the overlap area to position subsequent pattern areas with high accuracy by image processing. Dot marks are generated by beam induced deposition in the overlap areas at the end of the exposure process of each field. Then the sample is moved to the next field. The marks are searched by taking a highly magnified image scan in a reduced area. The mark position is evaluated by processing of this image to determine the new position of the sample. The position is obtained in the address scale used for exposure with an accuracy of ±1 address steps, which makes it possible to stitch the adjacent pattern in the next field with this precision. Having a ‘‘coarse’’ field or stage positioning means with 1-μm precision is now sufficient to obtain patterns, which are stitched with an accuracy of 1 nm by using an address field of ≳14 bit for the overlapping fields and by sacrificing an area of &amp;lt;1% of the address area for the mark detection in the overlap region. The method is especially applicable to nanolithography with instruments and processes that allow inspection of the mark without destroying the lithography area. In this case, only the mark area of the size of a few pixels is lost for the patterning within the fields. This is especially valid for scanning probe lithographies and beam induced deposition lithography methods.
Assessment of radial EBUS-GS for disposition of fiducial gold marker in peripheral lung nodule before stereotaxic radiation therapy (2014)

INTRODUCTION : Radial EBUS using guide sheath (GS) is a minimally invasive technique that allows the sampling of peripheral lung nodule. AIM : To assess the use of EBUS-GS for gold fiducial marker disposition. METHODS : 28 patients underwent radial-EBUS with fiducial placement in a peripheral lung nodule at the Rouen University Hospital between May 2008 and December 2013. EBUS procedure was performed using a 4.0mm bronchoscope and a 17S Olympus® probe. After sampling (biopsy and brush) a 5 mm / 0.8 mm fiducial gold marker (Best Medical International, USA) was inserted into the distal tip of the bronchial brush and glued with lidocaine gel, for fiducial placement through the GS . RESULTS : 23 patients had a chronic respiratory insufficiency that forcluded lung surgical resection and conventional radiation therapy. Mean nodule diameter was 16mm [min-max= 6-32mm], with 24 nodules ≤ 20mm. There were 24 pulmonary cancers (8 adenocarcinoma, 10 squamous cancer cell, 6 other) and 4 metastases. The histology was known before the procedure in only 8 / 28 cases. 26 procedures were performed under local anesthesia. No adverse event was noted. Nodules were visualized using EBUS in 27/28. The marker was expulsed during cough immediately after the procedure in two cases, and remained stable in the nodules in the other cases. The markers were visible on x-ray 3 months after the procedure in 84% of the cases. CONCLUSION : Fiducial placement into peripheral nodule before stereotaxic radiation therapy is a safe and efficient technique using radial EBUS under local anesthesia.
Towards multidiffusive ultrasonic propagation for non destructive evaluation of concrete; theoretical overview (2006)

International audience
Design, Analysis, and Optimization of Ironless Stator Permanent Magnet Machines (2012)

This paper presents a methodology for the design, analysis, and graphical optimization of ironless brushless permanent magnet machines primarily for generator applications. Magnetic flux in this class of electromagnetic machine tends to be 3-D due to the lack of conventional iron structures and the absence of a constrained magnetic flux path. The proposed methodology includes comprehensive geometric, magnetic and electrical dimensioning followed by detailed 3-D finite element (FE) modeling of a base machine for which parameters are determined. These parameters are then graphically optimized within sensible volumetric and electromagnetic constraints to arrive at improved design solutions. This paper considers an ironless machine design to validate the 3-D FE model to optimize power conversion for the case of a low-speed, ironless stator generator. The machine configuration investigated in this paper has concentric arrangement of the rotor and the stator, solenoid-shaped coils, and a simple mechanical design considered for ease of manufacture and maintenance. Using performance and material effectiveness as the overriding optimization criteria, this paper suggests optimal designs configurations featuring two different winding arrangements, i.e., radial and circumferentially mounted. Performance and material effectiveness of the studied ironless stator designs are compared to published ironless machine configurations.
FD injection utilizing the wavefields generated by Marchenko redatuming: A target-oriented approach (2014)

Summary In the presence of a highly-scattering near surface, standard imaging techniques often do not succeed in producing accurate images of deeper targets. Improved images could be obtained removing the effect of the complex overburden from the data, but this requires a detailed velocity model for such a portion of the subsurface. Recently, a novel approach for retrieving the Green's function in an unknown medium from the reflection response measured at the acquisition surface and an estimate of the propagation velocity. These redatumed wavefields are redatumed below the complex near surface and then used as input for a finite-difference (FD) injection technique. This injection process will allow imaging techniques based on forward- and back-propagation, such as reverse-time migration (RTM), to produce a more accurate image of deeper targets. We introduce a workflow for the proposed method and illustrate its application with a numerical example based on a simple layered model.
Real-world evidence of stroke prevention in patients with nonvalvular atrial fibrillation in the United States: the REVISIT-US study (2016)

Rivaroxaban and apixaban were associated with less ICH than warfarin and both are likely associated with reductions in the combined endpoint. Further investigation to validate the numerically higher rate of ischemic stroke with apixaban versus warfarin is required.
Supplementary Video S4 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs (2023)

&lt;p&gt;Supplementary Video S4. Time-lapse images of hTERT-RPE1-Arl13b-GFP cells starved in serum-free Opti-MEM for 48 hours, then incubated for 3 hours in 1 µM ganetespib.&lt;/p&gt;
ZNRF Proteins Constitute a Family of Presynaptic E3 Ubiquitin Ligases (2003)

Protein ubiquitination has been implicated recently in neural development, plasticity, and degeneration. We previously identified ZNRF1/nin283, a protein with a unique, evolutionarily conserved C-terminal domain containing a juxtaposed zinc finger/RING finger combination. Here we describe the identification of a closely related protein, ZNRF2, thus defining a novel family of ZNRF E3 ubiquitin ligases. Both ZNRF1 and ZNRF2 have E3 ubiquitin ligase activity and are highly expressed in the nervous system, particularly during development. In neurons, ZNRF proteins are located in different compartments within the presynaptic terminal: ZNRF1 is associated with synaptic vesicle membranes, whereas ZNRF2 is present in presynaptic plasma membranes. Mutant ZNRF proteins with a disrupted RING finger, a domain necessary for their E3 function, can each inhibit Ca2+-dependent exocytosis in PC12 cells. These data suggest that ZNRF proteins play a role in the establishment and maintenance of neuronal transmission and plasticity via their ubiquitin ligase activity.
Flat Lenses for Ultra-lightweight Longwave-Infrared Broadband Imaging (2019)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Meem, S. Banerji, A. Majumder, B. Sensale-Rodriguez, and R. Menon, "Flat Lenses for Ultra-lightweight Longwave-Infrared Broadband Imaging," in Conference on Lasers and Electro-Optics, OSA Technical Digest (Optica Publishing Group, 2019), paper JTh2A.118. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Determinants of Conductive Hearing Loss in Tympanic Membrane Perforation (2015)

The degree of conductive hearing loss resulting from a tympanic membrane perforation would be expected with the size of perforation and pneumatization of middle ear and mastoid.
Cuffless Blood Pressure Measurement (2022)

Cuffless blood pressure (BP) measurement has become a popular field due to clinical need and technological opportunity. However, no method has been broadly accepted hitherto. The objective of this review is to accelerate progress in the development and application of cuffless BP measurement methods. We begin by describing the principles of conventional BP measurement, outstanding hypertension/hypotension problems that could be addressed with cuffless methods, and recent technological advances, including smartphone proliferation and wearable sensing, that are driving the field. We then present all major cuffless methods under investigation, including their current evidence. Our presentation includes calibrated methods (i.e., pulse transit time, pulse wave analysis, and facial video processing) and uncalibrated methods (i.e., cuffless oscillometry, ultrasound, and volume control). The calibrated methods can offer convenience advantages, whereas the uncalibrated methods do not require periodic cuff device usage or demographic inputs. We conclude by summarizing the field and highlighting potentially useful future research directions.
A Consistent Implementation of Point-Sources on Finite-Difference Grids (2020)

Summary In finite-difference (FD) simulations of the wave equation, point-sources are typically implemented by sampling a sinc function onto the FD grid. However, the sinc point-source is a suboptimal way to introduce a point-source, as (1) it can introduce ringing into the model and (2) computed synthetic traces with constant source-receiver distances (but varying offset with respect to the grid) do not yield identical results. We propose a new implementation of point-sources to use in FD modeling of the wave equation. This new point-source implementation is a function of the FD coefficients used to propagate the wavefield, and boosts or suppresses wavemodes such that the created wavefield corresponds to the spectrum that a true point-source would generate. Through homogeneous examples we show that this new point-source gives a good fit to analytical solutions, reduces ringing artifacts, and can compute synthetic traces for constant source-receiver distances (for a varying offset to the grid) that are identical to within machine precision.
Convenient Solid‐Phase Synthesis of Ureido‐Pyrimidinone Modified Peptides (2007)

Abstract Peptides have been modified with quadruple hydrogen bonding ureido‐pyrimidinone moieties to be applied in supramolecular architectures for biomedical applications. A convenient solid‐phase synthesis method was developed to functionalize peptide sequences with ureido‐pyrimidinone units. Two different ureido‐pyrimidinone synthons were used: based on a carbonyldiimidazole‐activated amine or on an isocyanate functionality. Oligopeptides were functionalized on the solid support using two coupling strategies: on the N‐terminus or selectively on the ϵ‐position of a C‐terminal lysine. Several peptides were modified to show the generality of the approach, varying from cell adhesion sequences, to collagen binding peptides and cysteine derivatives which can be used for native chemical ligation. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2007)
Crystal structure of mTNF (1996)

twitchin (B) containing the autoinhibited kinase domain and a Cterminal Ig-like domain shows that the Ig-like domain extends from the kinase domain opposite to the active site and exposes possible myosin interacting surfaces. Our studies of the regulation and domain architecture of giant protein kinases jointly with an analysis of autoinhibitory sequences of other autoinhibited kinases point to possible common and diverse features of the intrasteric regulatory mechanisms.
DeepLab2: A TensorFlow Library for Deep Labeling (2021)

DeepLab2 is a TensorFlow library for deep labeling, aiming to provide a state-of-the-art and easy-to-use TensorFlow codebase for general dense pixel prediction problems in computer vision. DeepLab2 includes all our recently developed DeepLab model variants with pretrained checkpoints as well as model training and evaluation code, allowing the community to reproduce and further improve upon the state-of-art systems. To showcase the effectiveness of DeepLab2, our Panoptic-DeepLab employing Axial-SWideRNet as network backbone achieves 68.0% PQ or 83.5% mIoU on Cityscaspes validation set, with only single-scale inference and ImageNet-1K pretrained checkpoints. We hope that publicly sharing our library could facilitate future research on dense pixel labeling tasks and envision new applications of this technology. Code is made publicly available at \url{https://github.com/google-research/deeplab2}.
Mechanisierung in der Landschaftspflege (1994)

Durch veranderte gesellschaftliche, strukturelle und politische Verhaltnisse gewinnt die Landschaftspflege als Instrument zum Erhalt unserer Kulturlandschaft zunehmend an Bedeutung. Zur Durchfuhrung der Pflegemasnahmen werden verschiedene Gerate eingesetzt, die meist direkt oder indirekt aus der Agrartechnik hervorgehen.