gebhart/patrepeval huggingface dataset:
Multi-Modal Clique-Graph Matching for View-Based 3D Model Retrieval (2016)

Multi-view matching is an important but a challenging task in view-based 3D model retrieval. To address this challenge, we propose an original multi-modal clique graph (MCG) matching method in this paper. We systematically present a method for MCG generation that is composed of cliques, which consist of neighbor nodes in multi-modal feature space and hyper-edges that link pairwise cliques. Moreover, we propose an image set-based clique/edgewise similarity measure to address the issue of the set-to-set distance measure, which is the core problem in MCG matching. The proposed MCG provides the following benefits: 1) preserves the local and global attributes of a graph with the designed structure; 2) eliminates redundant and noisy information by strengthening inliers while suppressing outliers; and 3) avoids the difficulty of defining high-order attributes and solving hyper-graph matching. We validate the MCG-based 3D model retrieval using three popular single-modal data sets and one novel multi-modal data set. Extensive experiments show the superiority of the proposed method through comparisons. Moreover, we contribute a novel real-world 3D object data set, the multi-view RGB-D object data set. To the best of our knowledge, it is the largest real-world 3D object data set containing multi-modal and multi-view information.
Purification and partial amino acid sequence of papain-solubilized class II transplantation antigens (1982)

Papain-solubilized human class II (HLA-DR) antigens have been purified from cadaveric spleens by ion-exchange chromatography, gel chromatography, and immunosorbent purification. The isolated papain-solubilized antigens comprised two subunits with apparent molecular weights of 23 000 and 30 000, respectively. The circular dichroism spectrum for the isolated class II antigens was similar to spectra recorded for HLA-A, -B, and -C antigens, immunoglobulins, and immunoglobulin fragments. Thus, class II antigens contain a considerable amount of beta structure. The small subunit (beta chain) exhibited extensive charge heterogeneity on two-dimensional isoelectric focusing polyacrylamide gel electrophoresis, whereas the large subunit (alpha chain) was more homogeneous. The structural heterogeneity of beta chains remained after neuraminidase treatment. The NH2-terminal amino acid sequence of the beta chains displayed multiple residues in several positions in accordance with the genetic polymorphism displayed by this chain. The alpha chain also displayed multiple residues in some positions, suggesting either that some of the genetic polymorphism of the class II antigens may be endowed in this chain or that multiple loci control the expression of several alpha chains. Papain-solubilized class II antigen subunits were homologous in their amino acid sequences with HLA-DR antigens of defined antigenic specificity as well as with murine I-E/C antigens.
Single Molecule Electrochemistry: Impact of Surface Site Heterogeneity (2016)

Probing the electrochemistry of single molecules is a direct pathway toward a microscopic understanding of a variety of electron transfer processes related to energy science, such as electrocatalysis and solar fuel cells. In this context, Zaleski et al. recently studied the single electron transfer reaction of the dye molecule rhodamine-6G (R6G) by electrochemical single molecule surface-enhanced Raman spectroscopy (EC-SMSERS) (J. Phys. Chem. C 2015, 119, 28226−28234). In that work, the reductions of the dye molecule R6G were not only observed in the same potential range as in the ensemble surface cyclic voltammogram but also seen under some less negative potentials. Aiming to understand and explain this experiment theoretically, we relate the binding energy of R6G+ adsorbed on a silver nanoparticle (AgNP) to its reduction potential and further use periodic density functional theory to calculate this adsorption energy at different local surface sites. Well-defined crystal facets and defective surfaces, are considered. We find that the calculated adsorption energy distribution of the strongest binding states at each surface site closely matches the potential range of the experimentally observed Faradaic events. Moreover, the underpotential events are explained by the metastable adsorption states with less binding strength compared with those corresponding to Faradaic events. Our study reveals the importance of the heterogeneity of surface structures on the AgNP and offers a new perspective on understanding single molecule electrochemical behavior.
Element-Level Microwave Filter Integration in Fully-Digital Phased Array Radar Systems (2022)

This study presents a compact third-order microwave filter that is implemented within a single cell of the multi-layer antenna laminate stack-up of the 1024-element, dualpolarized, fully-digital active electronically scanned array, Horus. In order to fit two S-band filters within a single cell of the antenna stack-up, the filter is designed using substrate integrated waveguide, evanescent-mode cavity resonators. These resonators are miniaturized by heavily loading them with lumped-element capacitors. To suppress the spurious resonances of the filter, the coupling-matrix based design approach is leveraged to produce a transmission zero at the undesired second mode of the resonators. Two of these filters are designed and fabricated in a single cell. Excellent agreement is achieved between the simulated and measured results.
Energetics of Lithium Insertion into Magnetite, Defective Magnetite, and Maghemite (2018)

At low concentrations of lithium insertion into inverse spinel magnetite Fe3O4, a phase change to rock-salt-like LixFe3O4 has been observed. We used density-functional-theory-based (DFT-based) calculations to study the structural origins of this phase change, the concentration at which it occurs, the role of iron vacancies, and the stability of the various motifs that form during the electrochemical reduction process in the Li–Fe–O ternary space up to x = 1.33. We compared our results to new experimental measurements of the open circuit voltage for 8–9 nm magnetite particles over a comparable range of lithium insertion. Of the vacant sites in magnetite (16c, 8b, and 48f) lithium insertion was found to be most stable on 16c. Coulomb interactions between the added lithium and iron at the 8a site in magnetite led to substantial displacement of the iron. As further lithium was added, the most energetically favored motif involved lithium clustering in 16c sites around the shifted 8a iron up to a total of three lithiums. In competition with the lithium clustering motif, lithium insertion could be accompanied by the full displacement of all 8a iron to 16c sites, to form the rock-salt-like LixFe3O4, saturating at x = 1. The defective rock-salt structure was found to be more stable than the lithium clustering motif for x ≥ 0.5. The rock-salt-like LiFe3O4 was found to be stable in the Li–Fe–O ternary space for a continuous range of Li–Fe organization on the 16c sites, stabilized by Coulomb interactions. For x < 1, neither the lithium clustering motif, nor the defective rock-salt-like structure for LixFe3O4 were stable against phase segregation to LiFe3O4 and Fe3O4. This phase segregation (0 < x < 1) occurred at a predicted voltage of ∼2.0 V. However, when iron vacancies on the 16d site were introduced, lithium insertion to those vacant 16d sites in Fe2.875O4, and γ-Fe2.67O4 (maghemite), resulted in stable intercalated materials at a predicted voltage of ∼3.0 V. Beyond the concentration of such iron vacancy sites, phase segregation was predicted to the rock-salt-like Li1.125Fe2.875O4 and Li1.33Fe2.67O4, again at ∼2.0 V. These results were consistent with measured open circuit voltages. Finally, the relative stability for several lithium compositions along the FeO to LiFeO2 tie line in the defective rock-salt structure suggested stable compound formation for a range of lithium–iron compositions, but without long-range order in the cation sublattice, consistent with what has been commonly observed in the literature.
Muzinöses Dünndarmkarzinom in einer Pankreatikojejunostomie nach Frey-Operation (2014)

Einleitung: Adenokarzinome des Dünndarms sind eine sehr seltene Entität maligner gastrointestinaler Tumore. Das Auftreten in einer anastomosierten Jejunumschlinge nach einer Frey-Operation ist bisher in der Literatur nicht beschrieben.
SHS in Italy: An overview (2008)

In this work, the evolution of SHS research and development taking place in Italy during the last twenty years are addressed. The activity performed by the Italian research groups involved in this field that belong to the Universities of Cagliari, Genoa, Pavia, and Sassari, Polytechnic of Turin, and National Research Council IENI-Milan, respectively, are presented. The major results obtained from both the modeling and experimental points of view are reviewed while highlighting the international collaborations of each research group.
Abstract 15554: Heart Failure-Related Hyperphosphorylation of Ser199 on Cardiac Troponin I Causes Divergent Effects on Cardiac Function at Baseline and During Ischemia-Reperfusion (2015)

Background: Phosphorylation of cardiac troponin I (cTnI) on Ser199 is significantly increased in human heart failure (HF), however its cardiac impact in vivo remains unknown. In addition, selective proteolysis of cTnI is a marker of myocardial injury and contributes to cardiac dysfunction in ischemia/reperfusion (I/R), and Ser199 phosphorylation affects cTnI proteolysis in vitro, thus whether Ser199 phosphorylation affects cardiac performance during I/R is of great interest. Methods and Results: We generated transgenic mice (TgS200D) carrying cTnI S200D mutation to mimic the site-specific hyperphosphorylation of murine Ser200 (equivalent to human Ser199). Cardiac function was first assessed in vivo using echocardiography. TgS200D mice demonstrated unaltered ejection fraction (EF), significantly prolonged isovolumic relaxation time, and normal left ventricular (LV) chamber size and wall thickness (n=10). LV pressure-volume studies showed preserved dp/dtmax, significantly decreased -dp/dtmin and increased relaxation time constant in TgS200D when compared to non-transgenic (NTg) control group at baseline (n=10). With increasing heart rates, the two groups showed similar enhancement in both systolic and diastolic function, suggesting the positive force-frequency relation is preserved in TgS200D (n=5). After isoproterenol injection (i.v. 40ng/min/kg), although a comparable increase in dp/dtmax was observed in both groups, there was no enhancement of -dp/dtmin in TgS200D in contrast to 15% of increase in NTg (n=5, p=0.019). After ischemia (30 min)/reperfusion (60 min), LV developed pressure was recovered by ~90% in isolated TgS200D hearts but only ~40% in NTg (n=5, p=0.003). Immunoblotting detected cTnI cleavage only in NTg hearts. Conclusions: Our results indicate that hyperphosphorylation of cTnI Ser199 1) impairs basal diastolic function but preserves systolic function, without LV hypertrophy or dilation; 2) blunts cardiac lusitropic response to β-adrenergic stimulation with isoproterenol; 3) protects heart against I/R injury, likely via preventing cTnI degradation. We propose a dual role of cTnI Ser199 hyperphosphorylaiton: contributing to HF with preserved EF but protecting heart during I/R.
Model Catalytic Studies of Liquid Organic Hydrogen Carriers: Dehydrogenation and Decomposition Mechanisms of Dodecahydro-N-ethylcarbazole on Pt(111) (2014)

Liquid organic hydrogen carriers (LOHC) are compounds that enable chemical energy storage through reversible hydrogenation. They are considered a promising technology to decouple energy production and consumption by combining high-energy densities with easy handling. A prominent LOHC is <i>N</i>-ethylcarbazole (NEC), which is reversibly hydrogenated to dodecahydro-<i>N</i>-ethylcarbazole (H<sub>12</sub>-NEC). We studied the reaction of H<sub>12</sub>-NEC on Pt(111) under ultrahigh vacuum (UHV) conditions by applying infrared reflection-absorption spectroscopy, synchrotron radiation-based high resolution X-ray photoelectron spectroscopy, and temperature-programmed molecular beam methods. We show that molecular adsorption of H<sub>12</sub>-NEC on Pt(111) occurs at temperatures between 173 and 223 K, followed by initial C-H bond activation in direct proximity to the N atom. As the first stable dehydrogenation product, we identify octahydro-<i>N</i>-ethylcarbazole (H<sub>8</sub>-NEC). Dehydrogenation to H<sub>8</sub>-NEC occurs slowly between 223 and 273 K and much faster above 273 K. Stepwise dehydrogenation to NEC proceeds while heating to 380 K. An undesired side reaction, C-N bond scission, was observed above 390 K. H<sub>8</sub>-NEC and H<sub>8</sub>-carbazole are the dominant products desorbing from the surface. Desorption occurs at higher temperatures than H<sub>8</sub>-NEC formation. We show that desorption and dehydrogenation activity are directly linked to the number of adsorption sites being blocked by reaction intermediates.
Transgenic overexpression of human DMPK accumulates into hypertrophic cardiomyopathy, myotonic myopathy and hypotension traits of myotonic dystrophy (2004)

Abnormal expression of human myotonic dystrophy protein kinase (hDMPK) gene products has been implicated in myotonic dystrophy type 1 (DM1), yet the impact of distress accumulation produced by persistent overexpression of this poorly understood member of the Rho kinase-related protein kinase gene-family remains unknown. Here, in the aged transgenic murine line carrying approximately 25 extra copies of a complete hDMPK gene with all exons and an intact promoter region (Tg26-hDMPK), overexpression of mRNA and protein transgene products in cardiac, skeletal and smooth muscles resulted in deficient exercise endurance, an integrative index of muscle systems underperformance. In contrast to age-matched (11-15 months) wild-type controls, hearts from Tg26-hDMPK developed cardiomyopathic remodeling with myocardial hypertrophy, myocyte disarray and interstitial fibrosis. Hypertrophic cardiomyopathy was associated with a propensity for dysrhythmia and characterized by overt intracellular calcium overload promoting nuclear translocation of transcription factors responsible for maladaptive gene reprogramming. Skeletal muscles in distal limbs of Tg26-hDMPK showed myopathy with myotonic discharges coupled with deficit in sarcolemmal chloride channels, required regulators of hyperexcitability. Fiber degeneration in Tg26-hDMPK resulted in sarcomeric disorganization, centralization of nuclei and tubular aggregation. Moreover, the reduced blood pressure in Tg26-hDMPK indicated deficient arterial smooth muscle tone. Thus, the cumulative stress induced by permanent overexpression of hDMPK gene products translates into an increased risk for workload intolerance, hypertrophic cardiomyopathy with dysrhythmia, myotonic myopathy and hypotension, all distinctive muscle traits of DM1. Proper expression of hDMPK is, therefore, mandatory in supporting the integral balance among cytoarchitectural infrastructure, ion-homeostasis and viability control in various muscle cell types.
Modeling a one-dimensional bremsstrahlung and neutron imaging array for use on Sandia’s Z machine (1999)

Inertial confinement fusion is being studied on the Z facility at Sandia National Laboratories. Z is a large z-pinch machine which can provide 20 MA of current to z-pinch loads producing ∼1.8 MJ of soft x rays in less than 10 ns. Within the pinch region, decelerated electrons produce a strong source of bremsstrahlung radiation which varies from shot to shot. Additionally, a variety of inertial confinement fusion targets may produce fusion neutrons, the intensity and distribution of which depend on the temperature and density of the pinch. In this article, we describe the computer modeling behind the shielding design of a simple time-resolved, one-dimensional imaging array. This diagnostic will provide a time history for both the bremsstrahlung and neutron production as a function of height in the target. Calculations show that by building an array of scintillator fibers separated by long, thin tungsten collimator plates, a sampling rate of 0.254 mm at the target can be achieved. The corresponding channel-to-channel discrimination for such a design is shown to be better than 1000∷1 for &amp;lt;4 MeV photons and 100∷1 for 2.45 MeV neutrons. By coupling scintillator fibers to a fiber-optic streak camera system, the system time response is expected to be dominated by the scintillator response (∼1.2 ns).
Semi-Supervised Learning in Network-Structured Data via Total Variation Minimization (2019)

We provide an analysis and interpretation of total variation (TV) minimization for semi-supervised learning from partially-labeled network-structured data. Our approach exploits an intrinsic duality between TV minimization and network flow problems. In particular, we use Fenchel duality to establish a precise equivalence of TV minimization and a minimum cost flow problem. This provides a link between modern convex optimization methods for non-smooth Lasso-type problems and maximum flow algorithms. We show how a primal-dual method for TV minimization can be interpreted as distributed network optimization. Moreover, we derive a condition on the network structure and available label information that ensures that TV minimization accurately learns (approximately) piece-wise constant graph signals. This condition depends on the existence of sufficiently large network flows between labeled data points. We verify our analysis in numerical experiments.
A YAC clone map spanning 7.5 megabases of human chromosome band Xq28 (1994)

Xq28 has been of special interest in human genetics because a large number of diseases map to this region. As a step in the molecular analysis of the as yet uncloned disease genes, and as a test for the detailed analysis of larger regions of the genome, we have constructed YAC clone contigs covering the 7.5 Mb region between IDS to the telomere on the long arm of the human X chromosome. Contigs were assembled and verified by an integrated hybridization-based strategy. Data was combined from the physical map, from YAC and cosmid mapping experiments, and from the localization of specific transcripts in the region. Two gaps in the YAC map of 250 and 100 kb were covered in part by the aid of cosmid clones, but small gaps of 50 kb each remain. The cloned region is expected to contain yet unidentified genes for at least ten genetic diseases. The construction of ordered YAC clone contigs of Xq28 represents an important step in the molecular identification of these genes, and the further analysis of one of the genetically most interesting regions of the human genome.
Dopamine transporter function assessed by antisense knockdown in the rat: Protection from dopamine neurotoxicity (2000)

The plasma membrane dopamine transporter is located on presynaptic nerve terminals and is responsible for the termination of dopaminergic neurotransmission via dopamine reuptake. The dopamine transporter may also contribute to the pathogenesis of Parkinson disease. Dopamine transporter expression correlates well with susceptibility to neuronal degeneration in 1-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine (MPTP)-induced parkinsonism. Recent studies have implicated the dopamine transporter in the uptake of both this neurotoxin and its metabolite, MPP(+), as well as another experimental neurotoxin, 6-hydroxydopamine. In these studies we examined the role of the dopamine transporter in the neurotoxicity of both MPP(+) and 6-hydroxydopamine in the rat brain using in vivo administration of phosphorothioate antisense oligonucleotides targeting dopamine transporter mRNA. Infusion of dopamine transporter antisense (1 nmol/day, 7 days) into the left substantia nigra pars compacta resulted in reduced (3)H-WIN 35-428 binding in the left striatum and significant levodopa and amphetamine-induced contralateral rotations. Unilateral pretreatment with dopamine transporter antisense prior to bilateral intrastriatal infusion of either MPP(+) or 6-hydroxydopamine resulted in asymmetrical striatal (3)H-WIN 35-428 binding and dopamine content as well as significant apomorphine-induced ipsilateral rotations, suggesting neuroprotection of nigrostriatal neurons on the antisense-treated side. Thus, the dopamine transporter appears to play a critical role in determining susceptibility to the experimental neurotoxins MPP(+) and 6-hydroxydopamine. In light of this, the dopamine transporter may prove useful, both as a marker for susceptibility to Parkinson's disease and as a target for therapeutic intervention.
Room temperature soldering of microelectronic components for enhanced thermal performance (2005)

A novel fluxless soldering process is presented, that enables lead-free soldering of semiconductor die-to-heat spreader (and heat spreader-to-heat sink structures) at room temperature. The process is based on the use of reactive multilayer foils to locally melt the solder interface. Silicon-copper samples joined with indium solder are thermally characterized for a range of die sizes and bond line thicknesses. The thermal resistance of the solder joints is found to be an order of magnitude lower than for conventional thermal interface materials (TIMs), with good thermal fatigue resistance. The predicted thermo-mechanical behavior of the solder interface in a central processing unit (CPU) application indicates that such joints would survive application environments without causing die cracking. The soldering technology employed could greatly enhance the thermal performance of power IC packages such as CPUs, by enabling the adoption of a solder-based TIM between the die and integrated heat spreader.
Data from Clinical and Biological Efficacy of Recombinant Human Interleukin-21 in Patients with Stage IV Malignant Melanoma without Prior Treatment: A Phase IIa Trial (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Human interleukin-21 (IL-21) is a class I cytokine that mediates activation of CD8&lt;sup&gt;+&lt;/sup&gt; T cells, natural killer (NK) cells, and other cell types. We report final clinical and biological results of a phase II study of recombinant human IL-21 (rIL-21) in patients with metastatic melanoma.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Open-label, single-arm, two-stage trial. Eligibility criteria: unresectable metastatic melanoma, measurable disease by Response Evaluation Criteria in Solid Tumors, no prior systemic therapy (adjuvant IFN permitted), adequate major organ function, good performance status, no significant autoimmune disease, and life expectancy at least 4 months. Primary objective: antitumor efficacy (response rate). Secondary objectives: safety, blood biomarkers, and generation of anti-rIL-21 antibodies. rIL-21 (30 μg/kg/dose) was administered by intravenous bolus injection in 8-week cycles (5 dosing days followed by 9 days of rest for 6 weeks and then 2 weeks off treatment).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Stage I of the study comprised 14 patients. One confirmed complete response (CR) was observed, and as per protocol, 10 more patients were accrued to stage II (total &lt;i&gt;n&lt;/i&gt; = 24: 10 female and 14 male). Best tumor response included one confirmed CR and one confirmed partial response, both with lung metastases. Treatment was overall well tolerated. Biomarker analyses showed increases in serum soluble CD25, frequencies of CD25&lt;sup&gt;+&lt;/sup&gt; NK and CD8&lt;sup&gt;+&lt;/sup&gt; T cells, and mRNA for IFN-γ, perforin, and granzyme B in CD8&lt;sup&gt;+&lt;/sup&gt; T and NK cells.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; rIL-21 administered at 30 μg/kg/d in 5-day cycles every second week is biologically active and well tolerated in patients with metastatic melanoma. Confirmed responses, including one CR, were observed.&lt;/p&gt;&lt;/div&gt;