gebhart/patrepeval huggingface dataset:
Individual design of aberration-free intraocular lenses (2021)

An analytical tool capable of easily calculating a new aspheric intraocular lens (IOL) (shape factor, aspherization) chosen to be designed as “aberration free” in terms of spherical aberration and/or coma is reported. In terms of retinal image quality, the theoretical performances given by the new proposed IOLs compare well with commercial IOLs.
Generic UDP Encapsulation for IP Tunneling (2013)

This document describes a method of encapsulating arbitrary protocols
within GRE and UDP headers. In this encapsulation, the source UDP port
may be used as an entropy field for purposes of loadbalancing while
the payload protocol may be identified by the GRE Protocol Type.
Session details: Specification language and model transformations to support synthesis and design (2007)

No abstract available.
The COURAGE trial in perspective (2008)

The indications for percutaneous coronary intervention (PCI) continue to evolve because of the steady improvement in technology, broadened patient and lesion selection criteria, and new evidence from clinical trials. Recently, the role of PCI in patients with chronic stable angina has received considerable scrutiny and has been the subject of great controversy. In these patients, the goals of therapy include the relief of symptom, treatment of ischemia, and reducing the need for subsequent interventions. Medical therapy is the cornerstone in the management of coronary artery disease and should be optimized in all patients. The COURAGE trial investigated the efficacy of combined PCI and optimal medical therapy (OMT) versus OMT alone in patients with stable disease. The trial confirmed several issues that have been already well delineated: (1) in low risk patients, the hard endpoints of death and MI are relatively infrequent and are not reduced by PCI - for prevention of these, OMT may be sufficient, (2) crossover from OMT to PCI is frequent, even in low risk patients, (3) PCI is very effective in reducing symptoms and myocardial ischemia, and (4) significant untreated ischemia is associated with greater likelihood of death and MI.
An Improved Approach of Optical Loss Measurement Using Photocurrent and Optical Transmission in an Electroabsorption Modulator (2004)

We report an improved method to extract the optical absorption coefficient of a semiconductor electroabsorption modulator. Only the transmission and photocurrent data are needed with this method. The method makes it possible to obtain the optical coupling efficiency between laser and modulator, photocurrent conversion efficiency, and optical absorption coefficients from experimental data.
Properties of the self-deforming Ntb phase in mesogenic dimers (2013)

An overview of the results obtained from the most recent experiments performed for revealing the structure of the twistbend nematic N<sub>tb</sub> phase will be presented at the conference. This new phase provides typical X-ray diffraction pattern for the nematic phase and is found at temperatures below the conventional nematic phase in odd-chain hydrocarbon linked mesogenic dimers. The materials in the Ntb phase form self-deformed striped pattern parallel to the rubbing direction in planarly aligned rubbed cells with a well-defined period. The period is found to depend on the cell spacing. The selfdeformation stripes appear without any external electromagnetic field or thickness gradient across the cell. Although the materials are composed of non-chiral molecules, the low temperature nematic phase exhibits fast linear optical response of the order of a few microseconds. This response is reminiscent of the phase exhibiting chirality. Moreover, at higher fields some of the materials form striped domains with opposite direction of the optical response. These stripes appear normal to the rubbing direction and their periodicity depends on voltage and frequency. The Freedericksz transition in this phase also shows unusual properties and this is proven to be of the first order. The techniques to characterize this phase include polarized microscopy observation and optical contrast spectroscopy. Possible causes of the phenomena will be discussed.
Impaired Peripheral Vasomotion in Diabetes (1996)

Patterns of peripheral vasomotion are clearly disordered in diabetes. The loss of low-frequency oscillations observed here suggests a peripheral vascular abnormality that extends past the capillary network to arterial vessels. It is uncertain whether the accompanying small unmyelinated nerve C-fiber dysfunction is a cause or consequence of the impaired microvascular function. Measurement of vasomotion may prove useful as a novel test for peripheral neurovascular function.
Spotlight on afatinib and its potential in the treatment of squamous cell lung cancer: the evidence so far (2016)

Compared to adenocarcinoma, fewer effective treatment options are available for advanced or metastatic squamous cell carcinoma (SCC) of the lung. Afatinib is an orally administered, irreversible EGFR antagonist. As a second-generation tyrosine kinase inhibitor, it has been applied in the treatment of patients with EGFR-mutant non-small-cell lung cancer. Recently, several clinical trials have shown that afatinib leads to a significant improvement in progression-free survival and overall survival of patients with SCC. Moving forward, afatinib should be one of the options among tyrosine kinase inhibitors, monoclonal antibodies, and cytotoxicity chemotherapy drugs for SCC.
Far-infrared observations of sources associated with double-lobed reflection nebulae (1978)

Far-infrared observations of GL 915, 618, 2688 and OH 0739-14 are presented. The data provide information on the total flux arising in each of these sources, and on the wavelength-dependence of the emissivity of the associated dust. Two sources, GL 618 and GL 2688, have far-infrared continua similar to those recently observed in planetary nebulae.
See-through reflective metasurface diffraction grating (2019)

Metal-dielectric reflective metasurfaces with an engineered phase response provide a versatile alternative to conventional optics, especially when wanting to defy the basic law of reflection, as in compact near-eye display systems for augmented reality applications. Specifically, a key component of these display systems is a reflective grating with see-through function or capability. For a reflective metasurface, the transmission regime is typically not allowed due to a non-transparent metal backplate. In the current work, we propose a method to enable see-through metal-dielectric metasurfaces by etching apertures of random position and diameter (RPD) much larger than the design wavelength of the metasurfaces. We demonstrate a 1200 lp/mm metal-dielectric metasurface diffraction grating for use in reflection with 650 nm illumination. The fabricated device shows ∼20% diffraction efficiency in the first diffractive order over 0-50° angle of incidence, which is in agreement with the electromagnetic simulations. The device is semitransparent, letting ∼50% of the light illuminating the back of the device through via the RPD apertures. Furthermore, the light transmitted through the RPD apertures does not show any defined features due to diffraction (rings, fringes, etc.) aside from a quasi-uniform halo.
A bifunctionalStreptomyces-E. colipromoter-probe vetor (1990)

A bifunctional Streptomyces-E. coli promoter probe vector, pULJA30, has been developed to isolate and characterize nucleotide sequences involved in transcription initiation and regulation. The vector is derived from plasmid pIJ486 [1], carries the pIJ101 replicon and utilizes the promoterless amoniglycoside phosphotransferase (neo) as indicator gene. Important features of the new vector include: wide Streptomyces host range and as high a plasmid copy number as the parental pIJ486, an upstream transcriptional terminator (toop) and a polylinker sequence with unique sites for BamHI and BglII for flexible cloning, fragment re-isolation and direct sequencing of promoter-active inserts. pULJA30 also has an E. coli replicon (from pBR322) and the possibility of selection in Streptomycers and E. coli by using the tsr, neo and bla genes, which makes it very convenient to test the comparative functionality of Streptomyces promoters in E. coli.
Conformation and membrane activity of an analogue of the peptaibol antibiotic trichogin GA IV with a lipophilic amino acid at the N-terminus. (1998)

We have synthesized by solution-phase methods two analogues of the 11-residue lipopeptaibol antibiotic trichogin GA IV in which the N-terminal n-octanoyl group is replaced either by an N-acetylated 2-amino-2-methyl-L-undecanoic acid or by an N-acetylated alpha-aminoisobutyric acid. CD, FTIR absorption. and NMR analyses unequivocally show that the main structural features of trichogin GA IV are preserved in these analogues. Since only the peptide containing the lipophilic chain exhibits membrane-modifying properties, these results strongly support the view that moving the long acyl moiety from the Nalpha-blocking group to the side chain of the N-terminal extra-residue does not affect the conformational properties or the membrane activity of trichogin GA IV.
ANTHROPOLOGIE MOLECULAIRE ET EPIDEMIOLOGIE (2010)

En vingt ans, l'ADN mitochondrial (ADNmt) s'est impose comme un acteur majeur de l'anthropologie moleculaire. L'etude des polymorphismes de l'ADNmt a permis d'une part de reveler la proximite de l'homme avec le chimpanze et l'Homme de Neandertal et d'autre part de demontrer l'origine africaine de l'Homme moderne.ependant, durant la meme periode, des mutations pathogenes de l'ADNmt ont ete associees a des nombreuses maladies telles que des myopathies. Nous avons etudie si les polymorphismes de l'ADNmt pouvaient influencer les pathologies causees par les mutations pathogenes. Par la suite, nous avons etudie l'homogeneite du taux de mutation des lignees europeennes de l'ADNmt. Au terme de ces travaux nous proposons que (i) certaines lignees mitochondriales (haplogroupe J) ont accumule des polymorphismes pouvant influencer l'expression des pathologies et ayant pu jouer un role dans l'adaptation au climat des populations humaines. (ii) la phylogenie mitochondriale humaine presente un rythme de mutation rapide et stable, mais pouvant neanmoins presenter des irregularites de tempo sur certaines positions (hot- spot) ou certaines lignees (R0).
Effect of Roll Materials on Lubricity in Cold Rolling (1995)

The effect of rolls made of various tool steels on the lubrication characteristics are examined by rolling annealed low carbon steels by means of the simulation testing machine developed by one of the authors. The lubricity is evaluated by measuring the coefficient of friction for each test and the antiseizure property of rolls is evaluated by the observation of surfaces of rolled workpieces and rolls which are rolled under various conditions of rolling speed and reduction in thickness. The experimental results on the anti-seizure property are discussed based on the calculation of temperature at the interface between roll and workpiece and based on the observation of appearance of friction pick up on surface of rolls. The conclusion obtained are as follows ; (1) The difference of coefficient of friction among roll materials is small. (2) Anti-seizure property depends on the carbide content of roll material and it can be quantitatively evaluated by the calculated interfacial temperature. (3) Carbides on roll surface are effective for friction pick up.
Evaluation of the Swallow-Tail Sign and Correlations of Neuromelanin Signal with Susceptibility and Relaxations (2021)

The presence of a swallow-tail sign in the nigrosome-1 with hyperintense signal shown on the susceptibility-weighted imaging (SWI) has been shown to be sensitive in detecting the abnormal iron deposits in this area. A systematic evaluation in healthy subjects is required before this tool can be recommended in a widespread application. We evaluated a simple and practical SWI approach using a multiecho gradient-echo sequence with an improved contrast-to-noise ratio (CNR). We also evaluated the association of the neuromelanin imaging contrast behavior with the susceptibility and relaxation measurements. Twenty-five older and 23 young healthy adults were evaluated. The CNRs of the nigrosome-1 were compared along with method and group. Correlations of the nigrosome-1 neuromelanin signal in the neuromelanin-sensitive imaging with CNRs in the susceptibility, T1 and T2 mappings were examined. Two different coils were used to confirm the reproducibility. Compared with the single-echo, multiecho SWI can improve the CNR of the swallow-tail sign. We found significant correlations between neuromelanin signal and CNRs in the susceptibility and T2 mappings, and T1 value. The older subjects exhibited increased CNRs compared with the young adults. No significant difference was observed in the measurements between 20 and 64 channels. The multiecho technique allows the high-quality nigrosome-1 images in SWI and allows for a joint analysis of T2* and quantitative-susceptibility mapping at high spatial resolution. The correlations of neuromelanin-sensitive imaging with susceptibility and T2 imply that the iron content in the nigrosome-1 may have significant influences on the hyperintensity of neuromelanin in the magnetization transfer-related contrast.
A non-classical intercalation model for a bleomycin amplifier. (1988)

The bleomycin amplifier 1 is sterically hindered and twisted about the torsional bond joining the two aromatic rings. The intercalation of 1 and its sterically unhindered isomer 2 with DNA has been studied using n.m.r., viscometric titrations of superhelical and linear DNA, and flow dichroism. Based on the unusually strong interaction of 1 with DNA base pairs, a non-classical intercalation model for this compound is proposed. The intrinsic twists of both the unfused biaromatic system of 1 and the hydrogen-bonded DNA base pairs are retained in the intercalator-DNA complex, and the methyl group of 1 is accommodated between the hydrogen bonded bases. The complex of 1 is the first example found to date of this type of intercalation of the methyl group with DNA. The structure-activity relationships as bleomycin amplifiers for 1, 2 and similar derivatives is discussed.
Figure S4 from Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism (2023)

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The effects of drying technique and surface pre-treatment on the cytotoxicity and dissolution rate of luminescent porous silicon quantum dots in model fluids and living cells (2019)

Tailoring of the biodegradation of photoluminescent silicon quantum dots (Si QDs) is important for their future applications in diagnostics and therapy. Here, the effect of drying and surface pretreatment on the dissolution rate of Si QDs in model liquids and living cells was studied in vitro using a combination of photoluminescence and Raman micro-spectroscopy. Porous silicon particles were obtained by mechanical milling of electrochemically etched mesoporous silicon films, and consist of interlinked silicon nanocrystals (QDs) and pores. The samples were subjected to super-critical drying with CO2 solvent (SCD) or air drying (AD) and then annealed at 600 °C for 16 hours in 1% oxygen to obtain nano-sized Si QDs. The obtained samples were characterized by a core-shell structure with a crystalline silicon core and a SiO2 layer on the surface. The sizes of the crystalline silicon cores, calculated from Raman scattering spectra, were about 4.5 nm for the initial AD-SiQDs, and about 2 nm for the initial SCD-SiQDs. Both the AD-Si QDs and the SCD-Si QDs exhibited visible photoluminescence (PL) properties due to quantum confinement effects. The dissolution of the nanocrystals was evaluated through their PL quenching, as well as by the presence of a low-frequency shift, broadening, and a decrease in the intensity of the Raman signal. The stability of the AD-Si QDs and the complete dissolution of the SCD-Si QDs during 24 hours of incubation with cells have been demonstrated. This might explain the apparent lower cytotoxicity observed for SCD-Si QDs.
Induction of Secretagogue Independent Gastric Acid Secretion via a Novel Aspirin-Activated Pathway (2019)

Aspirin has been widely recommended for acute and chronic conditions for over 2,000 years. Either single or repetitive doses are commonly used for analgesic and antipyretic reasons and to prevent heart attacks, stroke, and blood clot formation. Recent studies show that it can also be used chronically to dramatically reduce the risk of a variety of cancers. However, prolonged usage of aspirin can cause severe damage to the mucosal barrier, increasing the risk of ulcer formation and GI-bleeding events. In the present study, we show the effects of acute low-dose aspirin exposure as an active secretagogue-inducing gastric acid secretion. Studies were carried out with isolated gastric glands using the pH-sensitive dye BCECF-AM to assess acid secretion. The non-selective NOS inhibitor L-NAME (30 μM), or the specific inhibitor ODQ (1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one) was applied while monitoring intracellular pH. The effects of basolateral exposure to aspirin (acetylsalicylic acid, ASA) caused activation of gastric acid secretion <i>via</i> the H<sup>+</sup>, K<sup>+</sup>-ATPase. Our data suggest that aspirin increases nitric oxide (NO) production, which in turn activates acid secretion. Exposure of gastric glands to either the non-selective NOS inhibitor L-NAME, and the highly selective, soluble guanylyl cyclase inhibitor 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) effectively inhibited aspirin-dependent gastric acid secretion. Aspirin can be considered as a novel secretagogue, in the way that it activates the H<sup>+</sup>, K<sup>+</sup>-ATPase. With increased daily aspirin consumption, our findings have important implications for all individuals consuming aspirin even in low doses and the potential risks for increased acid secretion.
Role of Adherence in the Pathogenesis of Pseudomonas aeruginosa Lung Infection in Cystic Fibrosis Patients (1980)

A correlation has been demonstrated between the in vitro adherence of Pseudomonas aeruginosa to upper respiratory tract epithelium and colonization of the respiratory tract by this organism. Twenty patients with cystic fibrosis (CF) and 20 age-matched controls were examined in this study. All of the CF patients but none of the controls were colonized with P. aeruginosa at the time of study. P. aeruginosa adherence to isolated epithelial cells, as determined by an in vitro assay, was 19.1 +/- 1.1 bacteria per buccal epithelial cell in the CF patients and 2.3 +/- 0.3 bacteria per cell in the controls (P < 0.01). P. aeruginosa strains of the mucoid colony type adhered in significantly lower numbers to buccal epithelial cells than did strains of the rough colony type (1.8 + 0.1 versus 24.8 +/- 0.9, P < 0.001). This difference might explain the common observation that the initial pseudomonas colonization of the respiratory tract of CF patients is due to organisms of the rough colony type. We have further demonstrated that increased P. aeruginosa adherence in vitro varies directly with the loss of a protease-sensitive glycoprotein, fibronectin, from the cell surface, as well as increased levels of salivary proteases in CF patients. When examined by a direct radioimmune binding assay, buccal cells from CF patients possessed only 17% of the total cell surface fibronectin present on similar cells obtained from controls. Salivary protease levels, as measured by (125)I release from an (125)I-labeled insoluble fibrin matrix, were increased about threefold in CF patients versus controls. Thus, colonization of the respiratory tract by P. aeruginosa in CF patients correlates well with buccal cell adherence of this organism; increased adherence is associated with decreased amounts of fibronectin on respiratory epithelial cell surfaces and increased levels of salivary proteases.
3×3 MIMO 60-GHz Direct-Detection OFDM RoFMF System with Mitigation of Optical Carrier Power Fading (2021)

We propose a novel method to mitigate the power fading effect in a V-band fiber-wireless 3x3 MIMO system. The proposed scheme can realize the 114.71-Gbps RoFMF system with 1.7-m FMF and 3-m wireless transmission.
Observation of an Inverse Kinetic Isotope Effect in a Co(III)-Catalyzed Polymerization of Ethylene (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationObservation of an Inverse Kinetic Isotope Effect in a Co(III)-Catalyzed Polymerization of EthyleneMartha J. Tanner, M. Brookhart, and J. M. DeSimoneView Author Information Department of Chemistry University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514 Cite this: J. Am. Chem. Soc. 1997, 119, 32, 7617–7618Publication Date (Web):August 13, 1997Publication History Received24 April 1997Published online13 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/ja971300shttps://doi.org/10.1021/ja971300srapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views653Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Isotope effects,Metals,Monomers,Transition states Get e-Alerts
Taste and aroma of fresh and stored mandarins (2010)

During the last decade there has been a continuous rise in consumption of fresh easy-to-peel mandarins. However, mandarins are much more perishable than other citrus fruit, mainly due to rapid deterioration in sensory acceptability after harvest. In the current review we discuss the biochemical components involved in forming the unique flavor of mandarins, and how postharvest storage operations influence taste and aroma and consequently consumer sensory acceptability. What we perceive as mandarin flavor is actually the combination of basic taste, aroma and mouth-feel. The taste of mandarins is principally governed by the levels of sugars and acids in the juice sacs and the relative ratios among them, whereas the aroma of mandarins is derived from a mixture of different aroma volatiles, including alcohols, aldehydes, ketones, terpenes/hydrocarbons and esters. During postharvest storage and marketing there is a gradual decrease in mandarin sensory acceptability, which has been attributed to decreases in acidity and typical mandarin flavor, paralleling an accumulation of off-flavor. Biochemical analysis of volatile and non-volatile constituents in mandarin juice demonstrated that these changes in sensory acceptability were concomitant with decreases in acidity and content of terpenes and aldehydes, which provide green, piney and citrus aroma on the one hand, and increases in ethanol fermentation metabolism products and esters on the other, which are likely to cause 'overripe' and off-flavors. Overall, we demonstrate the vast importance of the genetic background, maturity stage at harvest, commercial postharvest operation treatments, including curing, degreening and waxing, and storage duration on mandarin sensory quality.