gebhart/patrepeval huggingface dataset:
Production of $\Lambda$ and $K^0_s$ in jets in p–Pb collisions at $\sqrt {s_{NN}}$ = 5.02 TeV and pp collisions at $\sqrt {s}$ = 7 TeV (2022)

The production of Λ baryons and K$_S^0$ mesons (V0 particles) was measured in p–Pb collisions at $\sqrt {s_{NN}}$ = 5.02 TeV and pp collisions at $\sqrt{s}$ = 7 TeV with ALICE at the LHC. The production of these strange particles is studied separately for particles associated with hard scatterings and the underlying event to shed light on the baryon-to-meson ratio enhancement observed at intermediate transverse momentum (p$_T$) in high multiplicity pp and p–Pb collisions. Hard scatterings are selected on an event-by-event basis with jets reconstructed with the anti-k$_T$ algorithm using charged particles. The production of strange particles associated with jets p$_{T,jetch}$ &gt; 10 and p$_{T,jetch}$ &gt; 20 GeV/c in p–Pb collisions, and with jet p$_{T,jetch}$ &gt; 10 GeV/c in pp collisions is reported as a function of p$_T$. Its dependence on angular distance from the jet axis, R(V0,jet), for jets with p$_{T,jetch}$ &gt; 10 GeV/c in p–Pb collisions is reported as well. The p$_T$-differential production spectra of strange particles associated with jets are found to be harder compared to that in the underlying event and both differ from the inclusive measurements. In events containing a jet, the density of the V0 particles in the underlying event is found to be larger than the density in the minimum bias events. The Λ/K$_S^0$ ratio associated with jets in p–Pb collisions is consistent with the ratio in pp collisions and follows the expectation of jets fragmenting in vacuum. On the other hand, this ratio within jets is consistently lower than the one obtained in the underlying event and it does not show the characteristic enhancement of baryons at intermediate pT often referred to as “baryon anomaly” in the inclusive measurements.
Supplementary Table 3 from External Validation of a Multiplex Urinary Protein Panel for the Detection of Bladder Cancer in a Multicenter Cohort (2023)

&lt;p&gt;PDF file - 93K, Summary of 10-biomarker data in control case&lt;/p&gt;
Acid-Doped Biopolymer Nanocoatings for Flame-Retardant Polyurethane Foam (2022)

Soft furnishing fires contribute to 29% of fire causalities and $8.7 billion in direct property damage annually in the United States. Polyurethane foam (PUF), a common component in soft furnishings known for its comfort and flexibility, can emit toxic gases and propagate fires due to melt dripping when ignited. Various acid salts were added to a layer-by-layer assembled nanocoating, consisting of chitosan and carboxymethyl cellulose, to improve PUF flame retardancy and to understand the influence of salt-doping on flammability. The 20-bilayer phosphoric acid-doped coating exhibits a self-extinguishing behavior, with a 67% reduction in peak heat release rate while maintaining the structural integrity of the foam. By depositing this completely environmentally sourced coating on PUF, the inherent danger of soft furnishing fires can be significantly reduced in a nontoxic manner.
Effect of the Amount of Y2O3-Nd2O3 on the Sintering and High-Temperature Properties of Silicon Nitride. (1992)

The effect of the amount of added oxide on the gas-pressure sintering behavior of silicon nitride and high-temperature properties (strength and oxidation resistance) of the sintered materials were investigated. Si3N4 containing 0.5mol% (SN05) to 10% (SN10) of equimolar Y2O3-Nd2O3 was fired at 1900°C for 4h in 10MPa N2 gas. A small amount of the oxide (1mol%; SN1) was effective for densification as well as larger amounts of the oxide (6-10mol%). Composition analysis of the sintered specimens indicated that SN1 densified through a small amount of SiO2-rich liquid phase, whereas SN10 densified by a large amount of additive oxide-rich liquid phase. SN1 had higher strength than SN10 at higher temperatures because of its smaller amounts of glassy phase. SN1 also had an excellent oxidation resistance because the composition lied in the Si3N4-Si2N2O-Y2Si2O7 compatibility triangle, where Si2N2O and Y2Si2O7 were stable with regard to oxidation.
Modeling of image shutters and motion blur in analog and digital camera systems (2009)

For motion imaging the perceived smoothness of a sequence highly depends on motion blur. The exposure for each frame is started and ended with a shutter mechanism. There are different implementations and some of them have non-ideal behavior which can introduce artifacts. In this paper an overview of real-world shutter implementations both for analog and digital camera systems is shown. We develop a general description that models all types of shutters and their imperfections. Specific models for common shutter types are presented. Measurements are used to estimate unknown parameters. The modeled shutters are finally used for a virtual camera simulation. Typical artifacts can be simulated and directly compared for different shutter types and parameters. This powerful tool is useful for the construction of camera systems and allows design decisions to be directly compared before building the camera system.
Extended InGaAs on GaAs detectors for SWIR linear sensors (2001)

High quality extended-wavelength InGaAs (80% In) has been grown heteroepitaxially on 3'-GaAs substrates by means of Molecular Beam Epitaxy (MBE). In contrast growth on InP, sensor manufacturing on GaAs substrates can be readily scaled to 6'. An additional benefit is the larger cut-off of the 80%- In material (2.5&mu;m vs. 1.7&mu;m). The photodiode layer design was optimized for maximum improvement of dark current with temperature. A high-uniformity and high- yield process was developed to manufacture bondable 128 pixel 50 &mu;m pitch linear array sensors. To this end, a dedicated mesa-type process was developed assuring high uniformity in dark current and photoresponse. The sensors were designed for top-illumination. Sensors have been characterized electrically and optically at the intended thermo-electrical operation temperature (250K). The homogeneity of dark current and photoresponse was also evaluated at 250 K. The improvement in dark current as a function of temperature has been studied in more detail, yielding a zero bias resistance of approximately 2.5 M&Omega;cm<SUP>2</SUP> at 77K. A linear array has been bonded to a commercial CMOS read-out circuit and the functionality is shown. The sensor is suitable for spectroscopic and imaging applications in the short wavelength infrared (SWIR) region. Work is underway to develop sensors with smaller pitch and up to 512 pixels.
Design and Implementation of Digital Servo Controller for High Speed Machine Tools (1991)

This paper deals with the design of a digital servo controller for a machining tool which exhibits mechanical nonlinearities. Nonlinear friction force as well as its nonlinear compensation are considered. The combination of this compensator and the linear feedforward tracking controller(Zero Phase Error Tracking Controller) achieves high precision tracking and avoids serious problems such as quadrant glitches. Experimental and simulated results are shown and the superiority of the proposed control scheme is demonstrated.
Analysis by the polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus. (1992)

DNA sequence analysis of class II HLA from Caucasian and black patients with type 1 (insulin-dependent) diabetes mellitus has suggested that aspartic acid at position 57 (Asp 57) of the DQ beta chain provides protection against insulin-dependent diabetes mellitus (IDDM). In contrast, most Japanese patients with IDDM have Asp 57-positive alleles. To determine the reason for the differences and to localize the HLA-linked diabetogenic gene in Japanese, we studied the DQA1 and DQB1 genes of Japanese patients with IDDM and control subjects by the polymerase chain reaction in combination with restriction fragment length polymorphism analysis. Associations of DQA1*0301 and DQB1*0303 with IDDM were observed. DQA1*01 was associated negatively with IDDM. The HLA-DR9 haplotype, which is associated positively with IDDM in Japanese, was associated with DQA1*0301 and DQB1*0303, indicating that the Japanese DR9 haplotype is the same as that in caucasians but different from that in blacks. Of the loci on Japanese DR9 haplotypes, the DQA1*0301 allele showed the highest association with IDDM. DQB1*0303 was also positively associated with IDDM. Since DQB1*0303 is identical to DQB1*0302 except that it contains Asp 57, the data suggests that an Asp 57-positive allele confers susceptibility to IDDM when the whole molecule of the DQ beta chain is similar to other susceptible DQ beta chains. DQA1*0301 appears to be a marker of IDDM in all these populations: Japanese, caucasian, and black.
The effect of hormonal contraception on genital tract shedding of HIV-1 (2004)

A modest but significant increase in shedding of HIV-1 DNA but not of HIV-1 RNA was detected after starting hormonal contraception. Our results may have important implications regarding the infectivity of women using hormonal contraception, and highlight the need for epidemiologic studies of transmission rates from women using and not using hormonal contraception.
Has monitoring of the contralateral breast improved the prognosis in patients treated for primary breast cancer? (1986)

Bilateral breast cancer has a cumulative incidence of about 7% in patients with primary operable breast cancer, and most of these lesions are metachronous. Most retrospective studies have shown that a majority of these patients have invasive cancer in the second breast, and varying percentages have nodal metastases, which may be of a higher stage than the first cancer. Physicians are now more aware of the importance of careful monitoring of the second breast after ipsilateral mastectomy, and improvements have been made in mammographic surveillance. A retrospective, comparative analysis of two separate breast cancer populations at risk for bilateral breast cancer was done on patients who entered into the system before effective mammographic monitoring (BEM) and after effective mammographic monitoring (AEM). The first group of patients consisted of 500 consecutive patients with primary breast cancer diagnosed during the years 1969 through 1975, of whom 37 (7.4%) had bilateral breast cancer. The second group consisted of 557 consecutive patients diagnosed during the years 1977 through 1984, of whom 36 (6.5%) had bilateral breast cancer. The staging percentages of the second breast cancer in the BEM group were Stage 0, 5.4%; Stage I, 48.6%; Stage II, 10.8%; Stage III, 21.6%; and Stage IV, 13.5%. The second group had an improvement in stage, with 33.3% being Stage 0, 22.2% Stage I, 29.6% Stage II, 3.7% Stage III, and 3.7% Stage IV (P less than 0.05). The median interval between primary lesions was 39 months in the first group and 19 months in the second group (in part, this difference may represent increased identification of synchronous cancers). The second breast cancer was undetected by mammography in 9 of 34 (26%) patients. Six were detected by contralateral biopsy (all were lobular carcinomas in situ), and three were found by clinical examination (all were invasive cancers). It was concluded that more aggressive monitoring of the second breast by frequent clinical examination, mammography, and selected contralateral biopsy appears to have increased the early detection rate of second breast cancers in patients under observation.
Electrophysiological Effects of Penticainide (CM 7857) in Isolated Human Atrial and Ventricular Fibers (1989)

The intracellular electrophysiological properties of a new antiarrhythmic agent, penticainide (5 x 10(-6) to 5 x 10(-5) M) were studied in isolated driven human right atrial appendage and papillary muscle superfused with oxygenated Tyrode's solution. In atrial fibers, penticainide decreased the amplitude, maximum rate of rise (dV/dtmax), plateau amplitude, and duration (APD) of action potentials (AP). In ventricular fibers, the main AP modification induced by penticainide was a dV/dtmax diminution. All those effects were frequency and concentration dependent. Penticainide decreased resting potential at 5 x 10(-5) M only. Ventricular APD variations were relatively weak: in most of the cases, 5 x 10(-6) M decreased APD and 5 x 10(-5) M shortened long APD (greater than 300 ms) and lengthened short APD (less than 300 ms). The class I antiarrhythmic property (dV/dtmax decrease) of penticainide was rate dependent in both human fibers and was obtained at lower drug concentrations than those used in other species. The relatively rapid rate of onset and the rather slow recovery kinetics of dV/dtmax block suggest a common mechanism of action of penticainide on sodium channels in human heart and others mammals.
X-TIME: An in-memory engine for accelerating machine learning on tabular data with CAMs (2023)

Structured, or tabular, data is the most common format in data science. While deep learning models have proven formidable in learning from unstructured data such as images or speech, they are less accurate than simpler approaches when learning from tabular data. In contrast, modern tree-based Machine Learning (ML) models shine in extracting relevant information from structured data. An essential requirement in data science is to reduce model inference latency in cases where, for example, models are used in a closed loop with simulation to accelerate scientific discovery. However, the hardware acceleration community has mostly focused on deep neural networks and largely ignored other forms of machine learning. Previous work has described the use of an analog content addressable memory (CAM) component for efficiently mapping random forests. In this work, we develop an analog-digital architecture that implements a novel increased precision analog CAM and a programmable chip for inference of state-of-the-art tree-based ML models, such as XGBoost, CatBoost, and others. Thanks to hardware-aware training, X-TIME reaches state-of-the-art accuracy and 119x higher throughput at 9740x lower latency with &gt;150x improved energy efficiency compared with a state-of-the-art GPU for models with up to 4096 trees and depth of 8, with a 19W peak power consumption.
Prevalence and Types of Pitfall in the Assessment of Mitral Isthmus Linear Conduction Block (2012)

Every fifth assessment of bidirectional block across mitral isthmus linear lesion using differential coronary sinus and left atrial appendage pacing techniques encounters a pitfall, which can lead to erroneous clinical diagnosis of block or absence of block. Recognition of pitfall during the procedure is feasible and necessitates careful distinction of far-field left atrium from the local coronary sinus electrograms besides appropriate adjustments in catheter position and pacing outputs.
Simplified Discodermolide Analogues:  Synthesis and Biological Evaluation of 4-epi-7-Dehydroxy-14,16-didemethyl-(+)-discodermolides as Microtubule-Stabilizing Agents (2003)

Several novel analogues of (+)-discodermolide were synthesized via a convergent strategy that used Wittig reactions to append left and right side chains to a central scaffold and then tested for biological activity. Three of the analogues in the 4-epi-7-dehydroxy-14,16-didemethyl series, 6a-c, had interesting actions. The C3-methoxymethyl ether analogue 6b was more active in antiproliferative cell-based assays as well as in hypernucleation and paclitaxel site competition assays with isolated tubulin than the other analogues, including 6a, which contained a free hydroxyl group at the C3 position. The biological results validated the initial hypothesis that the C7 hydroxy group and the C14 and C16 methyl groups of (+)-discodermolide could be deleted without undermining activity. Although less potent than (+)-discodermolide and paclitaxel, compounds 6b and 6c both showed properties unique to (+)-discodermolide. These properties, particularly the capacity to cause hypernucleation of isolated tubulin at lower temperature than paclitaxel, as well as stabilizing preformed microtubules to cold disassembly, are considered mechanistically superior to those of paclitaxel. Other variations in the right and left sides of the discodermolide scaffold revealed additional structure/activity information.
Demonstration of Hole Transport and Voltage Equilibration in Self-Assembled π-Conjugated Peptide Nanostructures Using Field-Effect Transistor Architectures (2015)

π-Conjugated peptide materials are attractive for bioelectronics due to their unique photophysical characteristics, biofunctional interfaces, and processability under aqueous conditions. In order to be relevant for electrical applications, these types of materials must be able to support the passage of current and the transmission of applied voltages. Presented herein is an investigation of both the current and voltage transmission activities of one-dimensional π-conjugated peptide nanostructures. Observations of the nanostructures as both semiconducting and gate layers in organic field-effect transistors (OFETs) were made, and the effect of systematic changes in amino acid composition on the semiconducting/conducting functionality of the nanostructures was investigated. These molecular variations directly impacted the hole mobility values observed for the nanomaterial active layers over 3 orders of magnitude (∼0.02 to 5 × 10(-5) cm(2) V(-1) s(-1)) when the nanostructures had quaterthiophene cores and the assembled peptide materials spanned source and drain electrodes. Peptides without the quaterthiophene core were used as controls and did not show field-effect currents, verifying that the transport properties of the nanostructures rely on the semiconducting behavior of the π-electron core and not just ionic rearrangements. We also showed that the nanomaterials could act as gate electrodes and assessed the effect of varying the gate dielectric layer thickness in devices where the conventional organic semiconductor pentacene spanned the source and drain electrodes in a top-contact OFET, showing an optimum performance with 35-40 nm dielectric thickness. This study shows that these peptides that self-assemble in aqueous environments can be used successfully to transmit electronic signals over biologically relevant distances.
High‐throughput solid‐phase permethylation of glycans prior to mass spectrometry (2008)

Permethylation of glycans prior to their mass spectrometric determination has now become a time-honored methodology in glycoconjugate analysis due to the advantage of a simultaneous analysis of neutral and acidic glycans as well as enhanced sensitivity and easier tandem mass spectrometry interpretation. While the different solvent extraction-based versions of this method often suffice in different structural studies, they are generally less satisfactory in the quantitative determinations aiming at minor quantities of the analyzed materials. To overcome these difficulties, we recently introduced a solid-phase capillary permethylation technique (Kang et al., Rapid Commun. Mass Spectrom. 2005; 19: 3421) for microscale determination. Here, we describe a very useful high-throughput extension of the solid-phase methodology utilizing spin columns packed with sodium hydroxide beads. This procedure has been thoroughly optimized to match the analytical performance parameters of the previously used capillary technique. As demonstrated with a high-precision glycomic profiling analysis of human blood serum, this methodological improvement offers simplicity and reproducibility, allowing the complete permethylation of 12-18 samples in less than 20 min.
Modified N,N′‐Dicarbazolyl‐3,5‐benzene as a High Triplet Energy Host Material for Deep‐Blue Phosphorescent Organic Light‐Emitting Diodes (2011)

Deeply phosphorescent device: A high efficiency deep-blue phosphorescent organic light-emitting diode was developed using a high triplet energy host material with carbazole and diphenylphosphine oxide units. A high quantum efficiency of 22.4 % with a color coordinate of (0.14,0.17) was achieved (see figure).
Vinylester and Polyester 3D Printing (CRADA NFE-17-06792 Final Report) (2019)

In Phase 2 of the technical collaboration between Oak Ridge National Laboratory (ORNL) and Polynt Composites USA, a vinyl ester composite material for extrusion deposition additive manufacturing (AM) of thermoset materials was developed, characterized, and functionality demonstrated. Through this work modeling capability was developed to determine the desired in use material characteristics and refined process parameters. Coupon level testing was performed to validate the end use functionality of printed structures. Finally, the material was printed to evaluate its performance in composites tooling applications. This combined effort led to a commercial product, PRD-1520, for Polynt Composites USA specifically designed for large-scale extrusion deposition additive manufacturing of thermoset materials.
Daytime physical activity and sleep in pre‐schoolers with developmental disorders (2014)

A high level of morning and afternoon PA can advance the sleep phase in children with ASD.
Field Tests with a Fiber Optic Biosensor (1997)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text F. S. Ligler, G. P. Anderson, and E. Saaski, "Field Tests with a Fiber Optic Biosensor," in 12th International Conference on Optical Fiber Sensors, Vol. 16 of 1997 OSA Technical Digest Series (Optica Publishing Group, 1997), paper OThA1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Modeling the cost-effectiveness of treatment options for patients with clinical stage I non seminomatous germ cell tumors (NGSCT) (2004)

4525 Background: Survival rates for good risk clinical stage I NGSCT exceed 98%. Although long term outcomes for surveillance (SURV) and primary retroperitoneal lymph node dissection (RPLND) may be equivalent, their relative cost-effectiveness is unknown. Approximately 30% on SURV will relapse and will be treated with chemotherapy (CHEMO) +/- RPLND. We present a pilot study to model the cost effectiveness of SURV vs RPLND. Methods: Patients in 4 health states (>1 year post treatment) were evaluated: a) SURV b) RPLND c) CHEMO or d) RPLND and CHEMO. Utilities were collected using the EuroQol, Time Trade Off (TTO), Standard Gamble (SG) and Visual Analog Scale (VAS). Direct medical costs (DMC) were determined using the 2002 Medicare Fee Schedule. Costas and benefits were discounted 3% annually. Health care resource use was determined using National Comprehensive Cancer Network guidelines. Paients were assumed to have only one relapse and late relapses (more than 3 years) were considered equal in both groups. Quality Adjusted Life Years (QALY) =utility*life years. Cost effective ratio (C/E)=DMC/QALY. Decision analysis was modeled using a Markov process for a 25 year old man and tested using standard and probabilistic sensitivity analysis. Results: Mean utilities are listed in the table below. Total costs for RPLND:$48,372, SURV:$62,598(primarily due to increased diagnostic tests during SURV period). QALY were 23.33 and 24.77 respectively. The incremental C/E for surveillance was $9,870 per QALY, suggesting that SURV is cost effective. Conclusion: Though limited by the small sample size and the disproportionately few patients on SURV alone, this pilot study shows that this is a feasible model for determining cost-effectiveness. This will be used as a model for a future, larger study to further clarify this issue and guide clinicians in making treatment recommendations. No significant financial relationships to disclose.