gebhart/patrepeval huggingface dataset:
Molecular and behavioral mechanisms mediating paclitaxel‐induced changes in affect‐like behavior in mice (2019)

The antineoplastic paclitaxel is associated with negative affective outcomes, such as depression, anxiety, and decreased quality of life during treatment and convalescence. With the Baby Boomer population approaching peak cancer age, it is dire that the mechanisms behind paclitaxel‐induced changes in mood are uncovered. Cancer‐free male and female C57BL/6J mice were treated with one set of four injections of vehicle or paclitaxel (32mg/kg cumulative), or two sets of four injections of vehicle or paclitaxel (64mg/kg cumulative), and periodically assessed for depression‐like behaviors. Paclitaxel caused significant, time‐dependent deficits in sucrose preference and operant responding for palatable food. Because there is growing evidence to support the role of kappa opioid receptors (KORs) in stress‐mediated depression and reward dysfunction, we investigated KOR signaling as a putative mechanism of paclitaxel‐induced depression‐like behaviors. The selective KOR antagonist norbinaltorphimine (norBNI) reversed paclitaxel‐induced attenuation of sucrose preference. At the molecular level, paclitaxel time‐dependently induced an increase in the expression of Prodynorphin mRNA, the precursor for endogenous KOR agonists, in the nucleus accumbens (NAc). Using the [ 35 S]GTPγS assay, we discovered that a history of paclitaxel time‐dependently attenuated activation of dopamine D 2 receptors (D 2 R) and KORs in the NAc but not caudate putamen. These data suggest that paclitaxel‐induced changes in affect‐like behavior may be due to time‐ and region‐dependent dysregulation of KOR and D 2 R signaling. These observations help to establish the roles of KOR and D 2 R systems in paclitaxel‐induced disruption of behavioral reward, thus revealing potential neurochemical targets for therapeutic intervention in cancer survivors with treatment‐resistant depression. Support or Funding Information Supported by: Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship to Promote Diversity in Health‐Related Research 1F31CA224930‐01A1; NIH grant 1R01‐CA206028‐01; NIHNCI Cancer Center Support Grant P30‐CA016059. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
High-Capacity Mobile Fronthaul Transmission Using IF-Over-Fiber Technology for Next-Generation C-RAN Architectures (2018)

This invited paper overviews the potential of the intermediate frequency-over-fiber (IFoF) technology for future mobile fronthaul links, and clarify its advantages and disadvantages by comparing digital-based transmission scheme. Our recent achievements including 1-Tb/s-class CPRI-equivalent rate transmission are also presented.
A 65 ns CMOS 1Mb DRAM (1986)

This paper will cover a 5.3×9.6 mm CMOS 1Mb DRAM using a 28.5μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /l transistor cell with a self-aligned contact. The memory array has been placed in an N-well reducing the soft error rate below 1000FITs without die coat.
Coherence beamforming applied to velocity estimation and partially coherent signals (2015)

Time-delay and phase-shift estimators are often used to track speckle signals in order to estimate parameters such as strain, displacement, and velocity. These estimators rely on the beamformed RF signal to accurately estimate time and phase shifts. Partially coherent targets such as speckle, however, introduce variance and bias errors into the estimation because the delay-and-sum beamformer does not adapt to the spatial variation of the sampled waveform. In addition, the presence of acoustic and thermal noise can exacerbate this problem. We introduce a method that modifies the information used by the beamformer when it is applied to velocity and displacement estimation. Using simulations, velocity was estimated between RF channel signals, rather than beamformed RF signals, using Kasai's and Loupas' autocorrelation methods. Velocity and displacement was estimated from those channel signal pairs that exhibited high correlation. By eliminating incoherent information in Kasai's and Loupas' velocity estimators, jitter was reduced in high noise environments. For example, at 0 dB noise relative to the blood in the channel signals, Limiting the signal to high coherence signals (e.g. 10 spatial lags) reduced the jitter in the Kasai velocity estimator from approximately 6.0 mm/s to 2.5 mm/s. In general, jitter increased with increasingly incoherent information added into the beamformed signal and low noise yielded smaller jitter.
A low-power 2.5-GHz 90-nm level 1 cache and memory management unit (2005)

The design of a 90-nm virtually addressed cache subsystem with separate 32-kB instruction and data caches is described. The circuits and microarchitecture are illustrated, including architecture level trace data validating low-power features and provisions to support snooping while maintaining the latency and power of virtual addressing. Low-power memory management unit design including a translation lookaside buffer with process identifier mapping is also described. Level 1 caches with support for high bandwidth, single cycle 256 bit fill and evict, as well as features for low power are also described. The design approaches are validated through both simulation and experimental results.
Characterization of a distributed feedback laser with air/semiconductor gratings embedded by the wafer fusion technique (1999)

Wafer fusion between patterned or structured wafers is very useful in the construction of new optical materials and/or devices that have submicrometer-order structures inside semiconductors. In order to investigate the feasibility of wafer fusion for this purpose, a distributed feedback (DFB) laser wafer developed which has air/semiconductor gratings that are embedded using the wafer fusion technique. In this paper, the characteristics of the newly developed DFB laser and the coupling coefficient are investigated. Single-longitudinal-mode oscillation at 1.28 /spl mu/m is achieved under pulsed conditions at room temperature with a low threshold current density of 1.3 kA/cm/sup 2/, and the coupling coefficient is estimated to he approximately 100 cm/sup -1/. In addition, high-power surface emission (over 6 mW) is demonstrated due to the large difference between the refractive index of air and that of InP. These results indicate the feasibility of applying wafer fusion techniques to form submicrometer structures in semiconductors, and several other applications are expected.
ChemInform Abstract: TECHNICAL PROCEDURES FOR THE SYNTHESIS OF CAROTENOIDS AND RELATED COMPOUNDS FROM 6‐OXOISOPHORONE. VI. SYNTHESIS OF RHODOXANTHIN AND (3RS,3′RS)‐ZEAXANTHIN; ROUTES TO THE C15‐RING COMPONENT VIA 3‐OXOIONONE DERIVATIVES (1982)

Abstract Die Darstellung der als Cls ‐Ringbausteine zur Synthese von Rhodoxanthin und Zeaxanthin benötigten Phosphoniumsalze (VIII) wird beschrieben.
Technology for Successful Aging (2006)

Americans are living longer, and research shows that seniors are embracing independence, and will benefit from living in the same place. These are the rationale for `Aging in Place' and the development of Tiger Place, an "Aging in Place' Environment in Columbia Missouri. Our goal is to minimize intrusion, allow the resident complete control over privacy and treatment (if any), and to provide substantive improvement in quality of life. Nevertheless there continues to be significant risks to the elderly which results in reduced functional and cognitive activity. While there has been much technology developed to ameliorate these factors, there is no comprehensive evaluation of the benefit of these devices nor a comprehensive strategy to improve the quality of life of seniors as determined by functional ability and possibly later cognitive ability. With our partners at the University of Virginia we are developing a system of sensors, to monitor the activity of seniors in their residences. We measure motion, footfalls, sleep and restlessness, we have stove sensors and sensing mats, all connected wirelessly to a computer which performs an initial evaluation and data transfer to a secure server for further study. Based upon the monitor data we will implement an intervention to ameliorate functional decline. Focus group studies determine the attitudes, concerns and impressions of the residents and staff. We find that senior's attitude to technology is healthy and they will try helpful approaches.
Is nebulin the product of Duchenne muscular dystrophy gene? (1987)

In October 16th issue of Nature (1986), Louis Kunkel and his associates of Harvard Medical School announced the isolation of the gene the defect of which results in Duchenne muscular dystrophy and showed that its mRNA is as large as 16 kb.l) This suggests that the gene product has a huge molecular weight of more than 500,000. The possible candidate proteins, hitherto known, are nebulin (MW, 700 kDa) and connectin (also called titin; MW, 3000 kDa) in skeletal muscle, as first suggested by Orkin.2>
Fingerprinting Software-defined Networks (2015)

Software-defined networking (SDN) eases network management by centralizing the control plane and separating it from the data plane. The separation of planes in SDN, however, introduces new vulnerabilities in SDN networks since the difference in processing packets at each plane allows an adversary to fingerprint the network's packet-forwarding logic. In this paper, we study the feasibility of fingerprinting the controller-switch interactions by a remote adversary, whose aim is to acquire knowledge about specific flow rules that are installed at the switches. This knowledge empowers the adversary with a better understanding of the network's packet-forwarding logic and exposes the network to a number of threats. In our study, we collect measurements from hosts located across the globe using a realistic SDN network comprising of OpenFlow hardware and software switches. We show that, by leveraging information from the RTT and packet-pair dispersion of the exchanged packets, fingerprinting attacks on SDN networks succeed with overwhelming probability. We also show that these attacks are not restricted to active adversaries, but can be equally mounted by passive adversaries that only monitor traffic exchanged with the SDN network. Finally, we discuss the implications of these attacks on the security of SDN networks, and we present and evaluate an efficient countermeasure to strengthen SDN networks against fingerprinting. Our results demonstrate the effectiveness of our countermeasure in deterring fingerprinting attacks on SDN networks.
Charm-quark fragmentation fractions and production cross section at midrapidity in pp collisions at the LHC (2022)

Recent pT-integrated cross-section measurements of the ground-state charm mesons and baryons, D0, D+, Ds+, Λc+, and Ξc0, are used to evaluate the charm fragmentation fractions and production cross section per unit of rapidity at midrapidity (|y|&lt;0.5), in pp collisions at √s=5.02 TeV at the LHC. The latter is dσcc¯/dy||y|&lt;0.5=1165±44(stat)-101+134(syst) μb. These measurements were obtained for the first time in hadronic collisions at the LHC, including the charm baryon states, recently measured by ALICE at midrapidity. The charm fragmentation fractions differ significantly from the values measured in e+e- and ep collisions, providing evidence of the dependence of the parton-to-hadron fragmentation fractions on the collision system, indicating that the assumption of their universality is not supported by the measured cross sections. An increase of a factor of about 3.3 for the fragmentation fraction for the Λc+ with a significance of 5σ between the values obtained in pp collisions and those obtained in e+e- (ep) collisions is reported. The fragmentation fraction for the Ξc0 was obtained for the first time in any collision system. The measured fragmentation fractions were used to update the cc¯ cross sections per unit of rapidity at |y|&lt;0.5 at √s=2.76 and 7 TeV, which are about 40% higher than the previously published results. The data were compared with perturbative-QCD calculations and lie at the upper edge of the theoretical bands.
Optimal resource allocation and performance modeling in wireless networks in the presence of delay or fading. (2005)

This thesis addresses a number of problems in optimal resource allocation and performance analysis in wireless networks characterized by delay and fading. In the first part we address the problem of optimal bandwidth allocation among heterogeneous users sharing the same medium for transmission/reception. We limit our attention to centralized schemes where a controller allocates time slots to users according to their buffer state. The state information is delayed due to physical nature of the system. The objective is to minimize the total expected packet holding cost over a finite or infinite horizon. We first study the properties of an optimal policy for a two-user system and prove that under certain conditions a threshold type policy is optimal and a multiple slot allocation can be reduced to the problem of a single slot allocation. We then consider a myopic policy and study its optimality for an arbitrary number of users in scenarios where feedback delay is either due to propagation delay or duty cycling of the devices. In the second part we study the problem of optimal resource allocation in terms of transmission power and buffer size for a single user in a fading channel. This is formulated as a joint optimal power control (transmission rate) and admission control (acceptance rate) problem. Transmission power, packet buffering and packet dropping all incur costs to the user. The goal is to minimize the total cost over a finite or infinite horizon. We derive a number of properties of the optimal policy. In the last part of this thesis we study the performance of TCP connection splitting proxy over a satellite channel via detailed performance modeling and analysis on file transfer latency. We identify conditions under which using a proxy provides significant or marginal performance gain by investigating factors including initial window size, congestion level of the proxy, and the level of asymmetry between the segments segregated by the proxy. We also discuss how these conditions affect the deployment and provisioning of such systems.
The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts (2005)

Cigarette smoking can lead to chronic lung inflammation and lung cancer. Chronic inflammation, associated with expression of cyclooxygenase-2 (COX-2) and prostaglandins, predisposes to malignancy. We recently demonstrated that human lung fibroblasts are activated by cigarette smoke to express COX-2 and prostaglandin E(2) (PGE(2)). Little is known about the mechanism whereby smoke activates human lung fibroblasts to produce proinflammatory mediators. Herein, we report the central role of the aryl hydrocarbon receptor (AHR) in cigarette smoke extract (CSE)-induced COX-2, microsomal PGE(2) synthase (mPGES), and PGE(2) production in human lung fibroblasts. Western blot analysis revealed that primary strains of human lung fibroblasts express AHR and aryl hydrocarbon nuclear translocator protein, supporting the possibility that smoke activates lung fibroblasts through this pathway. Experiments were subsequently performed to determine whether the AHR was activated by CSE. Immunocytochemistry and EMSA analysis revealed that CSE induced nuclear translocation of the AHR in human lung fibroblasts. CSE decreased protein levels of the AHR, consistent with AHR ligand-induced proteosome-mediated degradation. CSE also induced mPGES-1 and COX-2 protein and increased PGE(2) production. Treatment of human fibroblasts with AHR antagonists in the presence of CSE inhibited AHR nuclear translocation as well as COX-2, mPGES-1, and PGE(2) production. These data indicate that the AHR pathway plays an important role in cigarette smoke-mediated COX-2 and PG production in human lung fibroblasts and may contribute to tobacco-associated inflammation and lung disease.
Multi-channel CMOS ASIC preamplifiers for APD and MSGC readouts (2004)

A 10-channel (Ch) and a 16-Ch application specific integrated circuit (ASIC) preamplifier chip with telescopic-cascode topology and gain-boosted folded-cascode topology respectively has been designed for avalanche photodiode (APD) and microstrip gas chamber (MSGC) readouts. These highly integrated and reliable chips can be used for individual readout from many channels to improve the spatial resolution and counting rate of such detectors over light sharing or charge division schemes. These chips were fabricated on a 2.4 mm times 2.4 mm die area using ROHM 0.35 mu CMOS technology. The chips were tested to have a low optimum equivalent noise charge (ENC) of about 880 e <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> . The gains of the 10-Ch and 16-Ch preamplifiers are (1.4-pF) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> and (1.1-pF) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> while the rise times are 15 s and 13 s respectively. The 16-Ch chip was used to readout GSO-APD detectors and an optimum energy resolution of 11.3% (551 keV peak of Na-22) was obtained while the coincidence time resolution with a BaF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> detector is about 11.5 ns. The energy resolution of Fe-55 with a 3 times 3 cm MSGC plate is about 20.5%.
Systematic Review of the Epidemiology of Complicated Peptic Ulcer Disease: Incidence, Recurrence, Risk Factors and Mortality (2011)

Complicated peptic ulcer remains a substantial healthcare problem which places patients at a high risk of recurrent complications and death.
The β3-Adrenergic Receptor and Susceptibility to Obesity, the Insulin Resistance Syndrome, and Noninsulin-Dependent Diabetes Mellitus (1998)

Although most forms of NIDDM in humans do not exhibit simple Mendelian inheritance, the large contribution of heredity is well recognized (1-5). Progress toward an understanding of the genetic basis of NIDDM has been largely restricted to a few distinct monogenic syndromes with predictable modes of inheritance. For example, one form of autosomal-dominant maturity-onset diabetes of the young (MODY) is caused by mutations in the glucokinase (M0DY2) gene (6,7) autosomal-recessive syndromes of extreme insulin resistance are the result of mutations in the insulin receptor gene (8) and maternally inherited diabetes and deafness (MIDD) is the result of mutations in mitochondrial DNA (9). These rare subphenotypes of diabetes are examples in which single gene defects have a major influence on the phenotype and for which environmental influences on expression of the phenotype are negligible.
Routine Postoperative Imaging is Important After Ureteroscopic Stone Manipulation (2002)

Our analysis suggests that silent obstruction remains a potentially significant complication after stone management. Relying on postoperative pain to determine the necessity of postoperative imaging places patients at risk for progressive renal failure due to unrecognized obstruction. Therefore, we recommend that imaging of the collecting system should be performed by excretory urography, spiral computerized tomography or ultrasound within 3 months after routine ureteroscopic stone treatment to avoid the potential complications of unrecognized ureteral obstruction.
Review article: From allergen genes to new forms of allergy diagnosis and treatment (2008)

Type I allergy represents an important health problem that affects more than 25% of the population in industrialized countries. Specific immunotherapy is one of the few causative treatment approaches for type I allergy and is currently performed with crude allergen extracts, which consist of a mixture of allergenic and nonallergenic components, are difficult to standardize and cannot be applied according to the patient's reactivity profile. With the introduction of molecular biological techniques into allergy research, a large panel of individual recombinant allergens has become available. Recombinant allergens can be used for improved diagnosis of allergy to determine the patient's sensitization profile, which is a prerequisite to select the allergens for patient-tailored immunotherapy. They allow the elucidation of the properties of allergens and of the mechanisms of allergy as well as of the mechanisms of immunotherapy. Moreover, recombinant allergens allow the development of hypoallergenic allergen derivatives with reduced allergenic activity and retained immunogenicity. First immunotherapy trials with hypoallergenic allergen derivatives have shown that this treatment might improve immunotherapy in the near future. This review summarizes the results, which were obtained with recombinant allergens and hypoallergenic allergen derivatives. The experiences from the in vitro and in vivo evaluation of the hypoallergenic derivatives and from clinical studies as well as the contribution of hypoallergenic derivatives to develop new treatment strategies and possibly prophylactic vaccination strategies are discussed.
Supplementary Figure Legends, Table Legends from CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions (2023)

&lt;p&gt;Supplementary Figure Legends, Table Legends&lt;/p&gt;
Understanding the Limitations of CNN-based Absolute Camera Pose\n Regression (2019)

Visual localization is the task of accurate camera pose estimation in a known\nscene. It is a key problem in computer vision and robotics, with applications\nincluding self-driving cars, Structure-from-Motion, SLAM, and Mixed Reality.\nTraditionally, the localization problem has been tackled using 3D geometry.\nRecently, end-to-end approaches based on convolutional neural networks have\nbecome popular. These methods learn to directly regress the camera pose from an\ninput image. However, they do not achieve the same level of pose accuracy as 3D\nstructure-based methods. To understand this behavior, we develop a theoretical\nmodel for camera pose regression. We use our model to predict failure cases for\npose regression techniques and verify our predictions through experiments. We\nfurthermore use our model to show that pose regression is more closely related\nto pose approximation via image retrieval than to accurate pose estimation via\n3D structure. A key result is that current approaches do not consistently\noutperform a handcrafted image retrieval baseline. This clearly shows that\nadditional research is needed before pose regression algorithms are ready to\ncompete with structure-based methods.\n
Inhibitors of Inducible NO Synthase Expression: Total Synthesis of (S)‐Curvularin and Its Ring Homologues (2008)

(S)-Curvularin and its 13-, 14-, and 16-membered lactone homologues were synthesized through a uniform strategy in which a Kochi oxidative decarboxylation and ring-closing metathesis reactions constitute the key processes. In the evaluation of the anti-inflammatory effects of the synthesized compounds in assays using cells stably transfected with a human iNOS promoter-luciferase reporter gene construct, the 14- and 16-membered homologues showed a slightly higher inhibitory effect towards iNOS promoter activity than curvularin itself. However, the larger ring homologues also exhibited higher cytotoxicity, manifest in downregulated eNOS promoter activity. In contrast, the di-O-acetyl and 4-chloro derivatives of (S)-curvularin showed higher inhibitory efficiency towards induction of the iNOS promoter and less negative effect on eNOS promoter activity than curvularin.