gebhart/patrepeval huggingface dataset:
Bruton's Tyrosine Kinase Is Involved in p65-mediated Transactivation and Phosphorylation of p65 on Serine 536 during NFκB Activation by Lipopolysaccharide (2005)

Bruton's tyrosine kinase (Btk) has recently been shown to participate in the induction of nuclear factor kappaB (NFkappaB)-dependent gene expression by the lipopolysaccharide (LPS) receptor Toll-like receptor-4 (TLR4). In this study we have examined the mechanism whereby Btk participates in this response. Treatment of the murine monocytic cell line Raw264.7 with LFM-A13, a specific Btk inhibitor, blocked LPS-induced NFkappaB-dependent reporter gene expression but not IkappaB alpha degradation. Transient transfection of HEK293 cells with Btk had no effect on NFkappaB-dependent reporter gene expression but strongly promoted transactivation of a reporter gene by a p65-Gal4 fusion protein. IkappaB alpha degradation activated by LPS was intact in macrophages from X-linked immunodeficiency (Xid) mice, which contain inactive Btk. Transfection of cells with a dominant negative form of Btk (BtkK430R) inhibited LPS-driven p65 mediated transactivation. Additionally LFM-A13 impaired phosphorylation of serine 536 on p65 induced by LPS in HEK293-TLR4 cells, and in Xid macrophages this response was impaired. This study therefore reveals a novel function for Btk. It is required for the signaling pathway activated by TLR4, which culminates in phosphorylation of p65 on serine 536 promoting transactivation by NFkappaB.
Synthesis of Alicyclic &#946;-lactams via the Ugi Reaction on a Solid Support (2004)

Via the Ugi 4-centre 3-component reaction (U-4C-3CR), bicyclic cis-2-azetidinone derivatives were synthetised from cyclic β-amino acids on Super Acid Sensitive Resin (Sasrin). 2-, 3- or 4-Formylbenzoic acid was immobilised on the resin through its carboxy function. The U-4C-3CR was also carried out in solution, making use of scavenger resins for purification. Keywords: ugi reaction, amino acids, solid support, sasrin resin, solid-phase scavengers
Zivilgesellschaft zwischen Freude und Frustration (2010)

Raffgierig reckt sich aus dem Hinterhalt eine klauenartige Frstenhand nach dem Volksvermgen, doch stoppt sie die wachsame Faust eines rechtschaffenen Arbeiters.In solch martialischen Bildern jedenfalls illustrierten unzhlige Propagandaplakate 1 eine der konfliktreichsten politischen Auseinandersetzungen der Weimarer Republik: die Frage nach einer materiellen Enteignung der ehemaligen Frsten des deutschen Kaiserreichs.In ihrer kurzen Lebenszeit von weniger als fnfzehn Jahren bot die Weimarer Republik
Trainable Frontend For Robust and Far-Field Keyword Spotting (2016)

Robust and far-field speech recognition is critical to enable true hands-free communication. In far-field conditions, signals are attenuated due to distance. To improve robustness to loudness variation, we introduce a novel frontend called per-channel energy normalization (PCEN). The key ingredient of PCEN is the use of an automatic gain control based dynamic compression to replace the widely used static (such as log or root) compression. We evaluate PCEN on the keyword spotting task. On our large rerecorded noisy and far-field eval sets, we show that PCEN significantly improves recognition performance. Furthermore, we model PCEN as neural network layers and optimize high-dimensional PCEN parameters jointly with the keyword spotting acoustic model. The trained PCEN frontend demonstrates significant further improvements without increasing model complexity or inference-time cost.
PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury (2018)

Stimulation of protease-activated receptor 1 (PAR1) on endothelium by activated protein C (APC) is protective in several animal models of disease, and APC has been used clinically in severe sepsis and wound healing. Clinical use of APC, however, is limited by its immunogenicity and its anticoagulant activity. We show that a class of small molecules termed "parmodulins" that act at the cytosolic face of PAR1 stimulates APC-like cytoprotective signaling in endothelium. Parmodulins block thrombin generation in response to inflammatory mediators and inhibit platelet accumulation on endothelium cultured under flow. Evaluation of the antithrombotic mechanism showed that parmodulins induce cytoprotective signaling through Gβγ, activating a PI3K/Akt pathway and eliciting a genetic program that includes suppression of NF-κB-mediated transcriptional activation and up-regulation of select cytoprotective transcripts. <i>STC1</i> is among the up-regulated transcripts, and knockdown of stanniocalin-1 blocks the protective effects of both parmodulins and APC. Induction of this signaling pathway in vivo protects against thromboinflammatory injury in blood vessels. Small-molecule activation of endothelial cytoprotection through PAR1 represents an approach for treatment of thromboinflammatory disease and provides proof-of-principle for the strategy of targeting the cytoplasmic surface of GPCRs to achieve pathway selective signaling.
Second-order nonlinear optical properties induced by thermal poling in photonic oxide glasses and transparent glass-ceramics (2010)

In recent years there has been a resurgence of interest in oxide glasses due to advances in lasers for information transport. Oxide glasses combine low cost of fabrication and good compatibility with silica glass fibers, which offer the opportunity for developing structures with nonlinear optical properties in integrated optical devices. The creation of an axial symmetry under thermal poling is currently necessary to induce Second-Order NonLinear (SONL) optical properties in glasses. A description of theoretical models which have been proposed for charge migration during thermal poling is presented. A review of SONL efficiencies which have been obtained for different glass compositions by this method is reported. Correlations between SONL properties and structural modifications under poling are also presented. Finally, we focus on the challenging fabrication of transparent glass-ceramic composites, especially when they are obtained by the precipitation of ferroelectric nanoparticle phases in the glassy matrix which adds the advantageous SONL properties of ferroelectric crystals.
Improved Sustainability of Railway Systems: The Tesys Rail Project (2016)

While an important part of the total carbon dioxide emission is still caused by transport systems, the impact of railway systems is significantly lower with respect to the other ground and air concurrent systems. However, the current development trends will produce a significant improvement of the efficiency of cars and planes, thus reducing the sustainability advantages of railway systems. This paper presents research work, based on the activities of the TESYS Rail Project, deals with the optimization of railway energy consumptions in order to increase the efficiency of the system. From the simulation of railway systems, the aim of the activity is to investigate how the use of energy storage devices can really improve efficiency in different operating scenarios, and involving different train typologies. A further goal of the activity is the development of integrated design, simulation and optimization tools and the generation of a code that can be integrated in real time applications. Finally, the model proposed in this paper has been validated with a set of experimental results provided by an industrial partner.
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers (2011)

Influenza nucleoprotein (NP) plays multiple roles in the virus life cycle, including an essential function in viral replication as an integral component of the ribonucleoprotein complex, associating with viral RNA and polymerase within the viral core. The multifunctional nature of NP makes it an attractive target for antiviral intervention, and inhibitors targeting this protein have recently been reported. In a parallel effort, we discovered a structurally similar series of influenza replication inhibitors and show that they interfere with NP-dependent processes via formation of higher-order NP oligomers. Support for this unique mechanism is provided by site-directed mutagenesis studies, biophysical characterization of the oligomeric ligand:NP complex, and an X-ray cocrystal structure of an NP dimer of trimers (or hexamer) comprising three NP_A:NP_B dimeric subunits. Each NP_A:NP_B dimeric subunit contains two ligands that bridge two composite, protein-spanning binding sites in an antiparallel orientation to form a stable quaternary complex. Optimization of the initial screening hit produced an analog that protects mice from influenza-induced weight loss and mortality by reducing viral titers to undetectable levels throughout the course of treatment.
The Mode of Germination of Zoophthora Radicans Zygospores (1982)

Dormancy of Zoophthora radicans resting spores was broken by storage at 4 C and 100% r.h. for 4–5 months. Germination began in 2–4 da at 16 C on water agar; maximum germination of 70% was observed after 20 da, either in continuous light or dark. Germination was similar to that previously described for Z. canadensis in that multiple germ conidia were produced. However, during the later stages of germ tube emergence, the epispore became roughened and dehisced, a phenomenon so far unique to Z. radicans among the entomopathogenic Entomophthorales.
Fast Learning from Sparse Data (2013)

We describe two techniques that significantly improve the running time of several standard machine-learning algorithms when data is sparse. The first technique is an algorithm that effeciently extracts one-way and two-way counts--either real or expected-- from discrete data. Extracting such counts is a fundamental step in learning algorithms for constructing a variety of models including decision trees, decision graphs, Bayesian networks, and naive-Bayes clustering models. The second technique is an algorithm that efficiently performs the E-step of the EM algorithm (i.e. inference) when applied to a naive-Bayes clustering model. Using real-world data sets, we demonstrate a dramatic decrease in running time for algorithms that incorporate these techniques.
Development and Validation of Endovascular Chemotherapy Filter Device for Removing High-Dose Doxorubicin: Preclinical Study (2014)

To develop a novel endovascular chemotherapy filter (CF) able to remove excess drug from the blood during intra-arterial chemotherapy delivery (IAC), thus preventing systemic toxicities and thereby enabling higher dose IAC. A flow circuit containing 2.5 mL of ion-exchange resin was constructed. Phosphate-buffered saline (PBS) containing 50 mg doxorubicin (Dox) was placed in the flow model with the hypothesis that doxorubicin would bind rapidly to resin. To simulate IAC, 50 mg of doxorubicin was infused over 10 min into the flow model containing resin. Similar testing was repeated with porcine serum. Doxorubicin concentrations were measured over 60 min and compared to controls (without resin). Single-pass experiments were also performed. Based on these experiments, an 18F CF was constructed with resin in its tip. In a pilot porcine study, the device was deployed under fluoroscopy. A control hepatic doxorubicin IAC model (no CF placed) was developed in another animal. A second CF device was created with a resin membrane and tested in the infrarenal inferior vena cava (IVC) of a swine. In the PBS model, resin bound 76% of doxorubicin in 10 min, and 92% in 30 min (P<i> </i><i><</i><i> </i>0.001). During IAC simulation, 64% of doxorubicin bound in 10 min and 96% in 60 min (P<i> </i><i><</i><i> </i>0.001). On average, 51% of doxorubicin concentration was reduced during each pass in single pass studies. In porcine serum, 52% of doxorubicin bound in 10 min, and 80% in 30 min (P<i> </i><i><</i><i> </i>0.05). CF device placement and administration of IAC were successful in three animals. No clot was present on the resin within the CF following the in vivo study. The infrarenal IVC swine study demonstrated promising results with up to 85% reduction in peak concentration by the CF device. An endovascular CF device was developed and shown feasible in vitro. An in vivo model was established with promising results supporting high-capacity rapid doxorubicin filtration from the blood that can be further evaluated in future studies.
First experience with cardiomyoplasty in Ukraine. (1995)

We have been studying feasible surgical alternatives for treating congestive heart failure, including the use of cardiomyoplasty. In this operation, skeletal muscles are conditioned, through electrical stimulation, to provide active tension on diseased myocardium, which improves left ventricular performance and ultimately increases cardiac output. We performed cardiomyoplasty in a 37-year-old man with severe ischemic cardiomyopathy. He was discharged from the hospital 2.5 months after the operation, and he did not require medical therapy. We believe this to be the 1st cardiomyoplasty performed in Ukraine.
Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2 (2018)

The influence of Arginine 117 of human cytochrome P450 2J2 in the recognition of ebastine and a series of terfenadone derivatives was studied by site-directed mutagenesis. R117K, R117E, and R117L mutants were produced, and the behavior of these mutants in the hydroxylation of ebastine and terfenadone derivatives was compared to that of wild-type CYP2J2. The data clearly showed the importance of the formation of a hydrogen bond between R117 and the keto group of these substrates. The data were interpreted on the basis of 3D homology models of the mutants and of dynamic docking of the substrates in their active site. These modeling studies also suggested the existence of a R117-E222 salt bridge between helices B' and F that would be important for maintaining the overall folding of CYP2J2.
Real-time, concurrent checkpoint for parallel programs (1990)

We have developed and implemented a checkpointing and restart algorithm for parallel programs running on commercial uniprocessors and shared-memory multiprocessors. The algorithm runs concurrently with the target program, interrupts the target program for small, fixed amounts of time and is transparent to the checkpointed program and its compiler. The algorithm achieves its efficiency through a novel use of address translation hardware that allows the most time-consuming operations of the checkpoint to be overlapped with the running of the program being checkpointed.
Electronic Properties of Olivine Materials for Positive Electrodes in Li-Ion Batteries (2012)

Abstract not Available.
Unexpected Temperature, Time and Solvent Effects in the Catalytic Asymmetric aza-Diels-Alder Reaction of an Ethyl Glyoxylate-derivedN-Aryl Imine with Danishefsky’s Diene Catalysed by a BINOL-Zinc Complex (2004)

The catalytic asymmetric aza-Diels-Alder reaction of an ethyl glyoxylate-derived N-aryl imine with Danishefsky’s diene using a BINOL-zinc complex provides the corresponding cycloadduct with moderate to high enantioselectivity, depending on the solvent, temperature and reaction time.
H2O on Graphene/Ir(111): A Periodic Array of Frozen Droplets (2014)

Scanning tunneling microscopy (STM) and thermal desorption spectroscopy (TDS) show that deposition of water molecules onto epitaxial graphene on Ir(111) leads to the formation of an extended and well ordered array of amorphous water clusters. We trace the evolution of this cluster phase as dependent on water exposure and deposition temperature. The formation of separated clusters is due to binding energy differences within the moiré superstructure.
Convergence of Fixed and Mobile Networks (2013)

This chapter gives overview of one of a recent trend in telecommunication convergence: fixed-mobile convergence (FMC). Its types, implications, and main challenges are identified and analyzed with special respect to the protocols employed. The future integration of fixed and mobile access to next generation networks (NGN) is investigated from several aspects, such as AAA (Authentication, Authorization, and Accounting) protocols, network and application layer mobility management solutions, and policy control. The focus is on access and core networks where the convergence is going to take place. At the end, a short outlook is given to near future mobile trends.
A 12–48 V wide-vin 9–15 MHz soft-switching controlled resonant DCDC converter (2017)

The presented wide-V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in</inf> step-down converter introduces a parallel-resonant converter (PRC), comprising an integrated 5-bit capacitor array and a 300 nH resonant coil, placed in parallel to a conventional buck converter. Unlike conventional resonant concepts, the implemented soft-switching control eliminates input voltage dependent losses over a wide operating range. This ensures high efficiency across a wide range of V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in</inf> = 12–48 V, 100–500 mA load and 5 V output at up to 15 MHz switching frequency. The peak efficiency of the converter is 76.3 %. Thanks to the low output current ripple, the output capacitor can be as small as 50 nF, while the inductor tolerates a larger ESR, resulting in small component size. The proposed PRC architecture is also suitable for future power electronics applications using fast-switching GaN devices.
Image-based tree modeling (2007)

In this paper, we propose an approach for generating 3D models of natural-looking trees from images that has the additional benefit of requiring little user intervention. While our approach is primarily image-based, we do not model each leaf directly from images due to the large leaf count, small image footprint, and widespread occlusions. Instead, we populate the tree with leaf replicas from segmented source images to reconstruct the overall tree shape. In addition, we use the shape patterns of visible branches to predict those of obscured branches. We demonstrate our approach on a variety of trees.
FpvB, an alternative type I ferripyoverdine receptor of Pseudomonas aeruginosa (2004)

Under conditions of iron limitation, Pseudomonas aeruginosa secretes a high-affinity siderophore pyoverdine to scavenge Fe(III) in the extracellular environment and shuttle it into the cell. Uptake of the pyoverdine-Fe(III) complex is mediated by a specific outer-membrane receptor protein, FpvA (ferripyoverdine receptor). Three P. aeruginosa siderovars can be distinguished, each producing a different pyoverdine (type I-III) and a cognate FpvA receptor. Growth of an fpvA mutant of P. aeruginosa PAO1 (type I) under iron-limiting conditions can still be stimulated by its cognate pyoverdine, suggesting the presence of an alternative uptake route for type I ferripyoverdine. In silico analysis of the PAO1 genome revealed that the product of gene PA4168 has a high similarity with FpvA. Inactivation of PA4168 (termed fpvB) in an fpvA mutant totally abolished the capacity to utilize type I pyoverdine. The expression of fpvB is induced by iron limitation in Casamino acids (CAA) and in M9-glucose medium, but, unlike fpvA, not in a complex deferrated medium containing glycerol as carbon source. The fpvB gene was also detected in other P. aeruginosa isolates, including strains producing type II and type III pyoverdines. Inactivation of the fpvB homologues in these strains impaired their capacity to utilize type I ferripyoverdine as a source of iron. Accordingly, introduction of fpvB in trans restored the capacity to utilize type I ferripyoverdine.
The association of modernization with dyslipidaemia and changes in lipid levels in the Polynesian population of Western Samoa (1997)

Current levels of dyslipidaemia in Western Samoa are similar to those observed in developed Western populations, and are increasing rapidly. These findings, considered along with the high prevalence of other cardiovascular disease risk factors in Samoans, including smoking, obesity and NIDDM, suggest that cardiovascular disease will be a major health concern in the future.
ADRM1‐amplified metastasis gene in gastric cancer (2015)

The proteasome ubiquitin receptor ADRM1 has been shown to be a driver for 20q13.3 amplification in epithelial cancers including ovarian and colon cancer. We performed array-CGH on 16 gastric cancer cell lines and found 20q13.3 to be amplified in 19% with the minimal amplified region in gastric cancer cell line AGS spanning a 1 Mb region including ADRM1. Expression microarray analysis shows overexpression of only two genes in the minimal region, ADRM1 and OSBPL2. While RNAi knockdown of both ADRM1 and OSBPL2 led to a slight reduction in growth, only ADRM1 RNAi knockdown led to a significant reduction in migration and growth in soft-agar. Treatment of AGS cells with the ADRM1 inhibitor RA190 resulted in proteasome inhibition, but RNAi knockdown of ADRM1 did not. However, RNAi knockdown of ADRM1 led to a significant reduction in specific proteins including MNAT1, HRS, and EGFR. We hypothesize that ADRM1 may act in ADRM1-amplified gastric cancer to alter protein levels of specific oncogenes resulting in an increase in metastatic potential. Selective inhibition of ADRM1 independent of proteasome inhibition may result in a targeted therapy for ADRM1-amplified gastric cancer. In vivo models are now warranted to validate these findings. © 2015 Wiley Periodicals, Inc.
Boron profile changes during low-temperature annealing of BF+2-implanted silicon (1988)

BF+2 ions were implanted in (100) silicon at room temperature with an energy of 40 keV through a 140-Å-thick SiO2 layer. Boron profiling by secondary-ion mass spectrometry indicates that subsequent annealing in a conventional furnace in the 650–850 °C range for 30–240 min results in a pronounced secondary peak in the B and F profiles, in addition to the near-surface primary peak located in the vicinity of the projected range of the implanted species. This phenomenon was also observed in BF+2 -implanted samples which were rapid thermal annealed at 900 °C for 15–60 s. The depths of the secondary peaks in the B and F profiles correspond to the depths of a damaged layer observed by cross-sectional transmission electron microscopy. Isochronal furnace annealing revealed that there is no chemical interaction between B and F atoms during annealing. This is also supported by the observation of F atoms not affecting the B segregation coefficient during oxidation of the BF+2 -implanted samples. The end-of-range extended dislocations appear to be responsible for the gettering of B and F atoms during annealing.
Figure S1 from Targeting the MYCN–PARP–DNA Damage Response Pathway in Neuroendocrine Prostate Cancer (2023)

&lt;p&gt;Expression of MYCN-PARP-DDR pathway genes in MYCN neutral and amplified neuroblastoma tumor samples.&lt;/p&gt;
Rotating Disk Studies in Molten Carbonates: I . Electrode Design (1994)

A rotating disk electrode has been designed, fabricated, and tested for use in high temperature molten salt systems to determine mass‐transport parameters that have been difficult to obtain hitherto due to experimental difficulties. The design incorporates a centrifugally cast and machined solid gold cone soldered to an Inconel shaft, which fits snugly in a precision‐machined high purity alumina sheath. A thermal expansion seal obtained when the electrode is heated to the experimental temperature prevents seepage of electrolyte between the gold and insulator. Preliminary tests have shown good performance.