gebhart/patrepeval huggingface dataset:
Cell proliferation arrest and tumor cell destruction by low intensity, frequency tuned electric fields (2004)

4331 We have shown for the first time that low intensity, intermediate frequency, alternating electric fields, delivered by means of insulated electrodes, have a profound effect on all living cells and tissues tested. The fields had a strong inhibitory effect on the growth rate and viability of a variety of human and rodent tumor cell lines (Patricia C, U-118, U-87, H-1299, MDA231, PC3, B16F1, F-98, C-6, RG2, and CT-26). These potentially tumor treating fields (TTFields) were applied to cells in culture via electrically insulated wires placed within the culture dishes. The effect of TTFields on cultures was assessed periodically during treatment using direct cell count, colorimetric cell number assessment or time-lapse microphotography. The same fields also had a profound effect on malignant tumors in animals. TTFields were applied to tumor bearing rodents either through intradermally implanted insulated electrodes, or through surface electrodes insulated with a specialized, high dielectric constant, insulation. The inhibitory effect of the TTFields on cancerous cell replication was found to be non-thermal and to selectively affect cell division in two modes: destruction of cells while undergoing division, and arrest of cell proliferation. The first mode of action is manifested by rapid disintegration of the dividing cells, while the second is associated with interference with the proper formation of the mitotic spindle. The last effect was demonstrated by post treatment staining of cultures with fluorescent antibodies against various intracellular constituents. Both effects, which are frequency dependent, are consistent with the computed directional forces exerted, by these specific fields, on charges and dipoles within the dividing cells. In view of the fact that in-vivo treatment of tumors in mice and rats, resulted in significant slowing of tumor growth and extensive destruction of tumor cells within 3 to 6 days, the described technology can potentially serve as a novel therapeutic modality for malignant tumors.
Implantation‐Related Complications (2008)

This chapter contains sections titled: Complications related directly to the implant procedure Implant or hardware-related complications that may result in recurrence of preimplantation symptoms (see also Chapter 10, Troubleshooting) References
Reactive Human-to-Robot Handovers of Arbitrary Objects (2021)

Human-robot object handovers have been an actively studied area of robotics over the past decade; however, very few techniques and systems have addressed the challenge of handing over diverse objects with arbitrary appearance, size, shape, and deformability. In this paper, we present a vision-based system that enables reactive human-to-robot handovers of unknown objects. Our approach combines closed-loop motion planning with real-time, temporally consistent grasp generation to ensure reactivity and motion smoothness. Our system is robust to different object positions and orientations, and can grasp both rigid and non-rigid objects. We demonstrate the generalizability, usability, and robustness of our approach on a novel benchmark set of 26 diverse household objects, a user study with six participants handing over a subset of 15 objects, and a systematic evaluation examining different ways of handing objects.
Mobile electric power for medium and heavy duty hybrid electric vehicles (2004)

The present paper describes a vehicle on-board power generation system rated 30 kVA, intended for medium and heavy duty hybrid electric vehicles, using the four-leg inverter technology. Control and PWM strategies, as well as experimental results are presented in detail.
Azide photoresist for thermal-laser imaging (1999)

Two azide-type compounds for thermal-laser photoresists have been investigated. One was an azide-pendant polyvinyl ether) as a binder polymer for positive imaging, and the other was a cyanine dye azide for negative imaging. The positive photoresist, which was composed of nigrosine as an infrared (IR)-absorbing dye and an azide-pendant polyvinyl ether), and the negative photoresist, which was composed of a Novolak resin and a cyanine dye azide as an IR-absorbing dye, were exposed by scanning a light spot of 15 mm from a 780 nm, 30 mW laser, giving sensitivities of 340 and 500 mJ/cm2 for the positive and the negative photoresist.
Evolution of Topologies, Modeling, Control Schemes, and Applications of Modular Multilevel Converters (2017)

Modular multilevel converter (MMC) is one of the most promising topologies for medium to high-voltage high-power applications. The main features of MMC are modularity, voltage and power scalability, fault tolerant and transformer-less operation, and high-quality output waveforms. Over the past few years, several research studies are conducted to address the technical challenges associated with the operation and control of the MMC. This paper presents the development of MMC circuit topologies and their mathematical models over the years. Also, the evolution and technical challenges of the classical and model predictive control methods are discussed. Finally, the MMC applications and their future trends are presented.
Recent Developments in the Discovery of Novel Adenosine Kinase Inhibitors: Mechanism of Action and Therapeutic Potential (2001)

Adenosine (ADO) is an endogenous inhibitory neuromodulator that limits cellular excitability in response to tissue trauma and inflammation. Adenosine kinase (AK; EC 2.7.1.20) is the primary metabolic enzyme regulating intra- and extracellular concentrations of ADO. AK inhibitors have been shown to significantly increase ADO concentrations at sites of tissue injury and to provide effective antinociceptive, antiinflammatory, and anticonvulsant activity in animal models. Structurally novel nucleoside and non-nucleoside AK inhibitors that demonstrate high specificity for the AK enzyme compared with other ADO metabolic enzymes, transporters, and receptors have recently been synthesized. These compounds have also demonstrated improved cellular and tissue penetration compared with earlier tubercidin analogs. These compounds have been shown to exert beneficial effects in animal models of pain, inflammation and epilepsy with reduced cardiovascular side effects compared with direct acting ADO receptor (P1) agonists, thus supporting the hypothesis that AK inhibitors can enhance the actions of ADO in a site- and event-specific fashion.
Supplementary Data from A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma (2023)

Supplementary Data from A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma
Interfenence Sources and Degrees of Freedom in Adaptive Nulling Antennas. (1982)

Abstract : It is sometimes desirable to know how many interference sources can N-element phased array or N-beam multiple-beam antenna can adaptively null. This problem is usually addressed by considering the antenna to have at most N-1 degrees of freedom available for placing null on interference sources. However, if some of the N-1 sources are very close together, it is possible that less than N-1 degrees of freedom are used. This paper quantitatively describes this effect by examining the eigenvalue spread of the interference covariance matrix. It is shown in the case of two equal-power interference sources in the field of view of either a multiple-beam antenna, or a phased array antenna, the two dominant eigenvalues are approximately equal when the source separation is equal to one half-power beamwidth. In other words, two degrees of freedom are consumed by two interference sources when they are separated by approximately one half-power beamwidth. This effect is also investigated for several configurations of three interference sources. To consume three degrees of freedom, it is shown that the eigenvalue spread is dependent on the interference source configuration and the antenna geometry. (Author)
Secondary Side-Channel Wireline Communication Using Transmitter Clock Frequency Modulation (2019)

A secondary communication link, or side-channel, is proposed, which uses binary frequency shift keying to modulate the frequency of a high-speed wireline transmitter clock. This side-channel data is then received using the corresponding receiver's conventional clock and data recovery (CDR) circuit. An analysis of the CDR loop parameters demonstrates that, within certain limits, the side-channel does not impact the signal integrity of the primary high-speed data. Measurements were made on a side-channel prototype using a 56-Gb/s PAM-4 (half-rate 14-GHz clock) transceiver in 7-nm FinFET technology through a 15-dB loss channel. Over 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> side-channel bits were transmitted at 50 kb/s, and the side-channel remained error-free with no visible impact on the high-speed link.
A wireless technology assessment for reliable communication in aircraft (2015)

Reliability certification of the aircraft communication infrastructure is a challenging task with any kind of wireless communication technology. In this paper a reliability framework is provided that is used to test wireless technologies against flight certification requirements. The required communication error rate of each technology is calculated against an exemplary application in order to form an understanding of the relationship between the system parameters. Results provide a guideline about the feasibility of candidate technologies for aircraft communication systems.
Failure Assessment Curves for Austenitic Stainless Steel Pipes with a Circumferential Crack at a Welded Joint. (2001)

The fracture assessment diagram approach is widely used to predict the fracture load or the critical crack size of nuclear components as in the ASME Code Case N-494. In this approach, a proper failure assessment curve must be defined to estimate fracture conditions accurately considering the effect of the thermal aging caused by long term operations. The present work deals with a crack located in the weldment of type 304 stainless steel pipes because of its higher susceptibility to the thermal aging than the base metal. So, the weldment was aged for 20, 000 hours at 400°C simulating long term operations of boiling water reactor (BWR) plants and was served to tests to obtain the mechanical properties of the aged weld metal. Using the stress-strain relationships of the unaged and aged metals, failure assessment curves are developed and compared with each other to make clear the effect of the thermal aging. Also the authors have checked the accuracy and conservatism of the curves stipulated in the R 6 approach and the ASME Code Case N-494 based on the present curve.
SYNTHETIC MODIFICATIONS OF ANTISENSE OLIGONUCLEOTIDES: NOVEL BACKBONE REPLACEMENTS WITH IMPROVED PROPERTIES (1994)

Abstract Eleven different types of backbone replacements have been investigated. The thermodynamic stability of the duplexes formed between these modified oligonucleotides and their RNA complements are summarized. Among these backbone replacements, we identified two amide derivatives which display improved properties for their application to the antisense strategy. A summary of our molecular modeling study on some of these modifications is also presented.
Electronic Cortisol Detection Using an Antibody-Embedded Polymer Coupled to a Field-Effect Transistor (2018)

A field-effect transistor-based cortisol sensor was demonstrated in physiological conditions. An antibody-embedded polymer on the remote gate was proposed to overcome the Debye length issue (λ<sub>D</sub>). The sensing membrane was made by linking poly(styrene- co-methacrylic acid) (PSMA) with anticortisol before coating the modified polymer on the remote gate. The embedded receptor in the polymer showed sensitivity from 10 fg/mL to 10 ng/mL for cortisol and a limit of detection (LOD) of 1 pg/mL in 1× PBS where λ<sub>D</sub> is 0.2 nm. A LOD of 1 ng/mL was shown in lightly buffered artificial sweat. Finally, a sandwich ELISA confirmed the antibody binding activity of antibody-embedded PSMA.
Glutathione S-Transferase and β-Glucuronidase Enzymes Inhibitory and Cytotoxic Activities of Ethanolic and Methanolic Extracts of Sri Lankan Finger Millet (Eleusine coracana (L.) Gaertn.) Varieties (2020)

International audience
Carbonate-Promoted Hydrogenation of Carbon Dioxide to Multicarbon Carboxylates (2018)

CO<sub>2</sub> hydrogenation is a potential alternative to conventional petrochemical methods for making commodity chemicals and fuels. Research in this area has focused mostly on transition-metal-based catalysts. Here we show that hydrated alkali carbonates promote CO<sub>2</sub> hydrogenation to formate, oxalate, and other C<sub>2+</sub> carboxylates at elevated temperature and pressure in the absence of transition-metal catalysts or solvent. The reactions proceed rapidly, reaching up to 56% yield (with respect to CO<sub>3</sub><sup>2-</sup>) within minutes. Isotope labeling experiments indicate facile H<sub>2</sub> and C-H deprotonations in the alkali cation-rich reaction media and identify probable intermediates for the C-C bond formations leading to the various C<sub>2+</sub> products. The carboxylate salts are in equilibrium with volatile carboxylic acids under CO<sub>2</sub> hydrogenation conditions, which may enable catalytic carboxylic acid syntheses. Our results provide a foundation for base-promoted and base-catalyzed CO<sub>2</sub> hydrogenation processes that could complement existing approaches.
Stereotactic Procedures (2013)

To remove toxins from the body, various blood-purication techniques have been used in clinical practice. e general approach of blood purication is to use a semipermeable membrane that selectively removes the solute by diusion, convection, and, optionally, adsorption. Blood-purication techniques can be broadly divided into two categories: intracorporeal therapies and extracorporeal therapies. In peritoneal dialysis, an example of an intracorporeal therapy, the native peritoneal membrane, which covers most of the intra-abdominal organs and forms the lining of the peritoneal cavity, functions as a semipermeable membrane. In contrast, during extracorporeal therapy, polymer membranes and sorbent cartridges are used to remove toxins and excess body water by concentration-driven, pressure-driven, electrochemical force, and specic antibody-driven operations. Currently, various combinations of hollow-ber membrane and sorbents support or replace internal organ functions. is chapter focuses on basic principles and clinical applications of extracorporeal blood-purication techniques to provide insights into contemporary and emerging blood-ltering techniques.
Modular High-Tg Second-Order Polymeric Nonlinear Optical Materials. Polyfunctional Epoxide and Diisocyanate Cross-Linked Chromophoric Polyhydroxystyrenes (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModular High-Tg Second-Order Polymeric Nonlinear Optical Materials. Polyfunctional Epoxide and Diisocyanate Cross-Linked Chromophoric PolyhydroxystyrenesEric T. Crumpler, Jennifer L. Reznichenko, Dequan Li, Tobin J. Marks, Weiping Lin, Paul M. Lundquist, and George K. WongCite this: Chem. Mater. 1995, 7, 4, 596–598Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/cm00052a002https://doi.org/10.1021/cm00052a002research-articleACS PublicationsRequest reuse permissionsArticle Views81Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Novel Conus Peptide Ligand for K+Channels (2003)

Voltage-gated ion channels determine the membrane excitability of cells. Although many Conus peptides that interact with voltage-gated Na(+) and Ca(2+) channels have been characterized, relatively few have been identified that interact with K(+) channels. We describe a novel Conus peptide that interacts with the Shaker K(+) channel, kappaM-conotoxin RIIIK from Conus radiatus. The peptide was chemically synthesized. Although kappaM-conotoxin RIIIK is structurally similar to the mu-conotoxins that are sodium channel blockers, it does not affect any of the sodium channels tested, but blocks Shaker K(+) channels. Studies using Shaker K(+) channel mutants with single residue substitutions reveal that the peptide interacts with the pore region of the channel. Introduction of a negative charge at residue 427 (K427D) greatly increases the affinity of the toxin, whereas the substitutions at two other residues, Phe(425) and Thr(449), drastically reduced toxin affinity. Based on the Shaker results, a teleost homolog of the Shaker K(+) channel, TSha1 was identified as a kappaM-conotoxin RIIIK target. Binding of kappaM-conotoxin RIIIK is state-dependent, with an IC(50) of 20 nm for the closed state and 60 nm at 0 mV for the open state of TSha1 channels.
Foxo3 Promotes Apoptosis of B Cell Receptor–Stimulated Immature B Cells, Thus Limiting the Window for Receptor Editing (2018)

Central tolerance checkpoints are critical for the elimination of autoreactive B cells and the prevention of autoimmunity. When autoreactive B cells encounter their Ag at the immature B cell stage, BCR cross-linking induces receptor editing, followed by apoptosis if edited cells remain autoreactive. Although the transcription factor Foxo1 is known to promote receptor editing, the role of the related factor Foxo3 in central B cell tolerance is poorly understood. We find that BCR-stimulated immature B cells from Foxo3-deficient mice demonstrate reduced apoptosis compared with wild type cells. Despite this, Foxo3<sup>-/-</sup> mice do not develop increased autoantibodies. This suggests that the increased survival of Foxo3<sup>-/-</sup> immature B cells allows additional rounds of receptor editing, resulting in more cells "redeeming" themselves by becoming nonautoreactive. Indeed, increased Igλ usage and increased recombining sequence recombination among Igλ-expressing cells were observed in Foxo3<sup>-/-</sup> mice, indicative of increased receptor editing. We also observed that deletion of high-affinity autoreactive cells was intact in the absence of Foxo3 in the anti-hen egg lysozyme (HEL)/membrane-bound HEL model. However, Foxo3 levels in B cells from systemic lupus erythematosus (SLE) patients were inversely correlated with disease activity and reduced in patients with elevated anti-dsDNA Abs. Although this is likely due in part to increased B cell activation in these SLE patients, it is also possible that low-affinity B cells that remain autoreactive after editing may survive inappropriately in the absence of Foxo3 and become activated to secrete autoantibodies in the context of other SLE-associated defects.
The Prussian States (2011)

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Spatio-temporal consistent depth maps from multi-view video (2011)

The demand for high quality depth maps from stereo and multi-camera videos increases constantly. The main application for these depth maps is rendering new perspectives of the captured scene by means of Depth Image Based Rendering (DIBR). Accurate depth maps are the linchpin of DIBR. On the basis of a four-camera set-up, we show that combining hybrid recursive matching with motion estimation, cross -bilateral post-processing and mutual depth map fusion produces spatio-temporal consistent depth maps appropriate for artifact-free view synthesis.
Robust Output Feedback Control for Discrete - Time Nonlinear Systems (1993)

In this paper we present a new approach to the solution of the output feedback robust control problem. We employ the recently developed concept of information state for output feedback dynamic games, and obtain necessary and sufficient conditions for the solution to the robust control problem expressed in terms of the information state. The resulting controller is an information state feedback controller, and is intrinsically infinite dimensional. Stability results are obtained using the theory of dissipative systems, and indeed, our results are expressed in terms of dissipation inequalities.
COVID-19 LDRD Project Summaries (2020)

Sandia National Laboratories currently has 27 COVID-related Laboratory Directed Research & Development (LDRD) projects focused on helping the nation during the pandemic. These LDRD projects cross many disciplines including bioscience, computing & information sciences, engineering science, materials science, nanodevices & microsystems, and radiation effects & high energy density science.
Figure S1 from TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations (2023)

&lt;p&gt;Supplemental Figure 1. Venn Diagram of Patients in the Study.&lt;/p&gt;
Hybrid Serverless Computing: Opportunities and Challenges (2022)

In recent years, there has been a surge in the adoption of serverless computing due to the ease of deployment, attractive pay-per-use pricing, and transparent horizontal auto-scaling. At the same time, infrastructure advancements such as the emergence of 5G networks and the explosion of devices connected to Internet known as Internet of Things (IoT), as well as new application requirements that constrain where computation and data can happen, will expand the reach of Cloud computing beyond traditional data centers into Hybrid Cloud. Digital transformation due to the pandemic, which accelerated changes to the workforce and spurred further adoption of AI, is expected to accelerate and the emergent Hybrid Cloud market could potentially expand to over trillion dollars. In the Hybrid Cloud environment, driven by the serverless tenants there will be an increased need to focus on enabling productive work for application builders that are using a distributed platform including public clouds, private clouds, and edge systems. In this chapter we investigate how far serverless computing can be extended to become Hybrid Serverless Computing.