gebhart/patrepeval huggingface dataset:
Nonlinear model predictive control leveraging quantum-inspired optimization in the three body problem with uncertainty (2023)

The optimization and control of spacecraft trajectories in presence of uncertainties and unmodeled disturbances represents a challenging problem. Future missions would benefit from robust control techniques to compute their trajectory in a complex, nonlinear environment and in presence of stochasticity. In this work the Stochastic Optimal Control problem in the Circular Restricted Three Body Problem is addressed and a method is proposed based on Nonlinear Model Predictive control (NMPC). This method presents the challenge of solving a nonlinear optimization problem on-board. A Quantum-inspired meta-heuristic optimization algorithm is tested in this context: the Diffusion Monte Carlo (DMC) method is based on a numerical techniques used in Quantum Mechanics, adapted to solve optimization problems. The NMPC with DMC is implemented, taking into account an estimate of the computational time required through the introduction of delayed actuation of the control. Two applications are presented featuring transfer trajectories between planar periodic orbits in the vicinity of the Moon; the proposed method proved able to successfully generate trajectories when disturbance accelerations and uncertain initial conditions are present.
A Comparison of Processed and Fresh Squeezed ‘Hamlin’ Orange Juice—Nutrients and Phytonutrients (2010)

‘Hamlin’ orange juices were prepared using one of following methods: 1) freshly squeezed with a commercial food service squeezer (fresh), 2) freshly squeezed and pasteurized (fresh/pasteurized), and 3) processed with industrial extractor and pasteurized (processed). Samples were taken from the juices directly after extraction and again after 4 d of juice storage at 5 °C for analysis of flavonoids, limonoids, alkaloids, carotenoids, ascorbic acid and total phenolic content. Processed juice had higher levels of insoluble solids, but lower levels of peel oil in comparison to fresh juice regardless of pasteurization. The majority of flavonoid glycosides including hesperidin, narirutin, narirutin 4´-glucoside, 6,8-di-C-glucosyl apigenin and isosakuranetin rutinoside, which are rich in the albedo and segment membranes, occurred at the highest levels in processed juice. In contrast, the polymethoxylatedflavones associated with peel oil, such as quercetagetin hexamethyl ether, sinensetin, nobiletin, tetramethylscutellarein, heptamethoxyflavone and tangeretin occurred at the highest levels in the fresh juices. Limonoids (limonin glucoside, limonin aglycone, nomilin glucoside, nomilinic acid glucoside, and nomilin aglycone), alkaloids (feruloyl putrescine and an unknown alkaloid) and carotenoids (zeaxanthin, lutein, s-cryptoxanthin, α-carotene and s-carotene) occurred at higher levels in the processed juice than in the fresh juice regardless of pasteurization. The processed juice had higher total phenolic content but lower ascorbic acid content than the fresh juices. Thermal pasteurization increased the contents of the polymethoxylated flavones, but decreased the contents of carotenoids. During 4-d storage at 5 °C, 20% to 80% of hesperidin, narirutin, narirutin 4´-glucoside and isosakuranetin rutinoside precipitated in the processed juice but not the fresh juice.
Optimizing Hydrant Selections for Conventional Flushing of Water Distribution Systems (2015)

Flushing water distribution network is a routine operation task for companies to ensure adequate water quality. This paper presents an optimization model, the extension of author’s previous work on optimal hydrant selection for fire flushing, for selecting hydrants to flush water distribution pipes without valve operations. The method is formulated to search for a given number of hydrants and the corresponding hydrant flows. Each of the selected hydrants is flushed one by one, so that the total length of the cleaned pipes is maximized. An example system C-Town network is used to demonstrate the application of the optimized hydrant selection and hydrant flow for flushing water pipeline network.
Perforin Expression in Human Cell-Mediated Luteolysis (1995)

After ovulation and in the absence of fertilization, the human corpus luteum regresses in an orderly sequence of morphological changes. This study demonstrated that luteal regression involved progressive infiltration of lymphocytes and macrophages. The inflammatory infiltrate began in the theca externa and gradually invaded granulosa cells, with maximum accumulation of lymphocytes and macrophages at the time of menstruation. Immunoperoxidase staining showed that the majority of lymphocytes were CD2+, CD3+, CD8+ T lymphocytes, and 15% of these T cells expressed perforin, a cytolytic protein implicated as a mediator of cytotoxicity. The remaining mononuclear infiltrate showed strong reactivity with monocyte/macrophage markers. These findings indicate that (a) a physiologic cell-mediated inflammatory process in the regressing human corpus luteum is mediated mainly by CD8+ T lymphocytes and cells of monocyte/macrophage lineage and (b) perforin expression in T lymphocytes supports a possible role for cytolytic T cells during the physiologic inflammatory response in human luteolysis.
FTY720 Demonstrates Promising in-Vitro and in-Vivo Pre-Clinical Activity by Down-Modulation of Cyclin D1 and Pakt in Mantle Cell Lymphoma. (2009)

Abstract Abstract 3728 Poster Board III-664 Over-expression of Cyclin D1 and constitutive phosphorylation of Akt has been implicated in the pathogenesis of mantle cell lymphoma (MCL). Here we describe FTY720 (fingolimod), an immunosuppressive agent currently being explored in phase III studies in renal transplantation and multiple sclerosis patients, to mediate time- and dose-dependent cell death in primary MCL cells (6 patients) and MCL cell lines, Jeko and Mino. FTY720-induced apoptosis was associated with reactive oxygen species (ROS) generation, Bax up-regulation but not associated with caspase 3 activation in MCL. FTY720 treatment resulted in time-dependent down-modulation of Cyclin D1 and phospho Akt (p-Akt) protein level, two critical disease-relevant molecules in the pathogenesis of MCL. Consistent with the modulation of Cyclin D1, FTY720-induced cell cycle arrest with accumulation of cells in G0/G1 and G2/M phases of the cell cycle with concomitant decrease in S phase entry. Importantly, FTY720 treatment was also associated with a time-dependent phospho Erk (p-Erk) induction in Mino and Jeko cells. To determine the in vivo efficacy of FTY720, we developed a preclinical, in vivo xenograft model of human MCL where MCL cell lines (Jeko, Mino and SP53) were engrafted into severe combined immune deficient (SCID) mice. Cell dose titration trials identified 4 × 107 Mino or Jeko cells injected intravenously via tail vein to result in consistent engraftment and fatal tumor burden in all mice. All mice engrafted with 4 × 107 Jeko cells developed a disseminated disease within 3 weeks and had a median survival of 28 days (compared to 43 days for Mino and 51 days for SP53). Because the Jeko cell line was established from the peripheral blood of a patient with blastic variant MCL and demonstrated a more resistant phenotype to several immuno-chemoterapeutic compounds, this cell line was chosen to create a more stringent in vivo preclinical model. SCID mice were treated with the monoclonal antibody TMβ1 to deplete murine NK cells, engrafted with 4 × 107 Jeko cells and observed daily for signs of tumor burden. Ten mice/group were treated starting at day 15 post-engraftment with intraperitoneal injection of 100 μl of saline or FTY720 (5 mg/kg resuspended in 100 μl of saline), every day, for two weeks. The median survival for FTY720-treated mice (N=10) was 38 days (95% CI:30-39) compared to 26.5 days (95% CI: 26-27 days) for the control group mice (N=10). The results from the log-rank test indicated an overall statistical significant difference in survival functions between the FTY720 treatment and the control group (p=0.001). These results provide the first evidence for a potential use of FTY720 in targeting key pathways that are operable in the pathogenesis of MCL and warrant the further investigation of FTY720 in combination with other agents in clinical trials treating patients with MCL. Disclosures: No relevant conflicts of interest to declare.
Molecular Cloning and Expression of CYP2J2, a Human Cytochrome P450 Arachidonic Acid Epoxygenase Highly Expressed in Heart (1996)

A cDNA encoding a human cytochrome P450 arachidonic acid epoxygenase was isolated from a human liver cDNA library. Sequence analysis revealed that this 1,876-base pair cDNA contained an open reading frame and encoded a new 502-amino acid protein designated CYP2J2. Blot hybridization analysis of RNA prepared from human tissues revealed that CYP2J2 was highly expressed in the heart. Recombinant CYP2J2 protein was prepared using the baculovirus expression system and purified to near electrophoretic homogeneity. The enzyme metabolized arachidonic acid predominantly via olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids (catalytic turnover 65 pmol of product formed/nmol of cytochrome P450/min at 30 degrees C). Epoxidation of arachidonic acid by CYP2J2 at the 14,15-olefin was highly enantioselective for (14R, 15S)-epoxyeicosatrienoic acid (76% optical purity). Immunoblotting of microsomal fractions prepared from human tissues using a polyclonal antibody raised against the recombinant hemoprotein confirmed primary expression of CYP2J2 protein in human heart. The in vivo significance of CYP2J2 was suggested by documenting the presence of epoxyeicosatrienoic acids in the human heart using gas chromatography/mass spectroscopy. Importantly, the chirality of CYP2J2 products matched that of the epoxyeicosatrienoic acid enantiomers present, in vivo, in human heart. We propose that CYP2J2 is one of the enzymes responsible for epoxidation of endogenous arachidonic acid pools in human heart and that epoxyeicosatrienoic acids may, therefore, play important functional roles in cardiac physiology.
Detection of Paracoccidioides brasiliensis gp43 Gene in Sputa by Loop‐Mediated Isothermal Amplification Method (2009)

The fungus Paracoccidioides brasiliensis is the pathogen of paracoccidioidomycosis (PCM), a systemic mycosis prevalent in Latin America. The loop-mediated isothermal amplification method (LAMP) was used in this study to detect the presence of P. brasiliensis in sputa samples from patients with chronic PCM, suspected PCM, and a negative control. The target P. brasiliensis gp43 gene was amplified in less than 4 hr in 11 of 18 sputa samples tested. The LAMP method had the advantage of speed and simplicity compared with the classic diagnostic methods such as the histopathological test or biological material culture and did not require sophisticated technical apparatus. It would be an important aid in cases where immediate treatment would mean patient survival, especially in immune-suppressed patients.
Bayesian techniques for onboard train localization (2009)

Precise train localization is a prerequisite for any efficient security and disposition tasks in modern transportation systems. In contrast to airplanes or ships, the localization of a train is not satisfyingly solvable with satellite systems. Occlusions in urban areas, tunnels and forests enforce the application of diverse sensor principles or cost intensive installations on track side. This contribution proposes an on-board train localization solely relying on a topological map and an eddy current sensor. The sensor principle is based on electromagnetic induction and is capable of estimating the speed of the train as well as detecting and classifying turnouts. These are represented by nodes in the map and allow absolute localization and recalibration of the distance measurement. Bayesian methods, in particular hidden Markov models in combination with the sequential Monte Carlo method, are used to solve the arising problems of a real-time and generalized detection and classification as well as localization within the topological map.
Discrimination between different kind of surface defects on Compac Discs (2004)

Compact Disc players have problems playing discs with surface defects such as scratches and finger prints. The problem is that handling normal disturbances such as mechanical shocks etc, require a high bandwidth of the controllers which keep the Optical Pick-Up focused and radial tracked on the information track on the disc. In order for the controllers to handle the surface defects it is required that they are non-sensitive to the frequency contents of the defect, since a defect can be viewed as a disturbance on the measurements. A simple solution to this problem is to decrease the controller bandwidth during the defect. However, due to the variation of defects a more adaptive control strategy would be preferable. In this paper the defects are categorised into three groups. A discriminator is designed, based on the local most discriminating basis vectors of the Karhunen-Loève and Haar bases as well as the mean of defect groups vectors. In these bases the discrimination rule is simple. The defect in question is a member of the group it is closest too. The Karhunen-Loève basis gives a correct classification rate of more than 85.7% with 3 basis vectors and the Haar basis of more than 94.6% with 5 basis vectors.
3D‐Printed Cathodes of LiMn1−xFexPO4 Nanocrystals Achieve Both Ultrahigh Rate and High Capacity for Advanced Lithium‐Ion Battery (2016)

A 3D‐printing technology and printed 3D lithium‐ion batteries (3D‐printed LIBs) based on LiMn 0.21 Fe 0.79 PO 4 @C (LMFP) nanocrystal cathodes are developed to achieve both ultrahigh rate and high capacity. Coin cells with 3D‐printed cathodes show impressive electrochemical performance: a capacity of 108.45 mAh g −1 at 100 C and a reversible capacity of 150.21 mAh g −1 at 10 C after 1000 cycles. In combination with simulation using a pseudo 2D hidden Markov model and experimental data of 3D‐printed and traditional electrodes, for the first time deep insight into how to achieve the ultrahigh rate performance for a cathode with LMFP nanocrystals is obtained. It is estimated that the Li‐ion diffusion in LMFP nanocrystal is not the rate‐limitation step for the rate to 100 C, however, that the electrolyte diffusion factors, such as solution intrinsic diffusion coefficient, efficiency porosity, and electrode thickness, will dominate ultrahigh rate performance of the cathode. Furthermore, the calculations indicate that the above factors play important roles in the equivalent diffusion coefficient with the electrode beyond a certain thickness, which determines the whole kinetic process in LIBs. This fundamental study should provide helpful guidance for future design of LIBs with superior electrochemical performance.
Peptide p277 of HSP60 signals T cells: inhibition of inflammatory chemotaxis (2006)

Peptide p277 is a 24-amino acid fragment of the heat shock protein 60 molecule, first discovered to be an antigen for diabetogenic T-cell clones in non-obese diabetic (NOD) mice. Therapeutic vaccination with p277 can arrest the spontaneous diabetogenic process both in NOD mice and in humans associated with a T(h)1 to T(h)2 cytokine shift specific for the autoimmune T cells. We now report that p277 can directly signal human T cells via innate toll-like receptor (TLR)-2, leading to up-regulation of integrin-mediated adhesion to fibronectin, and inhibition of chemotaxis to the chemokine SDF-1alpha in vitro. Resting CD45RA(+) T cells responded to lower concentrations of p277 than resting CD45RO(+) T cells, but activation of CD45RO(+) T cells greatly increased their sensitivity to p277. Mouse T cells, but not macrophages, were also sensitive to the innate effects of peptide p277, and adoptive transfer of diabetes by splenic T cells from NOD mice could be inhibited by p277 treatment before transfer. Thus, T cells do respond innately to p277, and signaling by soluble p277 through TLR2 could contribute to the treatment of type 1 diabetes; p277 may stop the destruction of beta cells by signaling in concert both innate and adaptive receptors on T cells.
A Monte Carlo evaluation of the accident rate of a plant equipped with an aging single-channel trip device (2017)

This paper discusses the evaluation of the accident rate of an industrial facility equipped with a single-channel protective system subjected to aging. This issue is very important for plant life extension. We discuss possible models for solving the problem and present an initial solution based on a Monte Carlo method. The model was validated by comparing channels with exponential failure time results with published results. It is concluded that the Monte Carlo approach gives reasonable results for typical plant demand rates for at least 5,000 trials.
High-quality p–n junctions with quaternary AlInGaN/InGaN quantum wells (2000)

We report on quaternary AlInGaN/InGaN multiple quantum well (MQW) light emitting diode structures grown on sapphire substrates. The structures demonstrate high quality of the p–n junctions with quaternary MQW. At low forward bias (below 2 V), the temperature dependent of current–voltage characteristics are exponential with the ideality factor of 2.28, which is in a good agreement with the model of the injected carrier recombination in the space charge region. This ideality factor value is approximately three times lower than for conventional GaN/InGaN light emitting diodes (LEDs). The obtained data indicate the recombination in p–n junction space charge region to be responsible for a current transport in LED structures with quaternary quantum wells. This is in contrast to InGaN based LEDs, where carrier tunneling dominates either because of high doping of the active layer or due to the high density of localized states.
Multipath sequence maintenance (2000)

This document discusses the issue of packet re-ordering which occurs
as a specific problem in multi-path connections without reliable
transport protocols such as TCP. The topic is relevant for devices
connected via multiple accesses technologies towards the network as is
foreseen e.g. within Access Traffic Selection, Switching, and
Splitting (ATSSS) service of 3rd Generation Partnership Project (3GPP)
enabling fixed mobile converged (FMC) scenario.
ChemInform Abstract: Palladium‐Catalyzed Coupling of Vinylogous Amides with Aryl Halides: Applications to the Synthesis of Heterocycles. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Development of an IT equipment lumped capacitance parameter database for transient data center simulations (2014)

The transient behavior of IT equipment can be represented by a lumped thermal capacitance for use in data center level transient thermal simulations. Previous work has proposed a mathematical methodology to extract the necessary lumped capacitance parameters, the server's time constant and heat transfer effectiveness, via air temperature measurements. This work describes and experimentally tests that proposed methodology to introduce a possible approach for developing an easy-to-use database of lumped capacitance characteristics for use in transient thermal simulations. The database will allow the user to select the appropriate transient parameters based on characteristics that do not require an “autopsy” of each-and-every server in the data center. Experiments are conducted to provide representative transient parameters which classify the servers by mass density and operating air flow rate. The paper describes the experimental methodology in detail to allow for the easy addition of other IT equipment or future server generations.
Preoperative Amiodarone as Prophylaxis against Atrial Fibrillation after Heart Surgery (1997)

Preoperative oral amiodarone in patients undergoing complex cardiac surgery is well tolerated and significantly reduces the incidence of postoperative atrial fibrillation and the duration and cost of hospitalization.
Programming Massively Parallel Processors, Third Edition: A Hands-on Approach (2016)

Programming Massively Parallel Processors: A Hands-on Approach, Third Edition shows both student and professional alike the basic concepts of parallel programming and GPU architecture, exploring, in detail, various techniques for constructing parallel programs. Case studies demonstrate the development process, detailing computational thinking and ending with effective and efficient parallel programs. Topics of performance, floating-point format, parallel patterns, and dynamic parallelism are covered in-depth. For this new edition, the authors have updated their coverage of CUDA, including coverage of newer libraries, such as CuDNN, moved content that has become less important to appendices, added two new chapters on parallel patterns, and updated case studies to reflect current industry practices. Teaches computational thinking and problem-solving techniques that facilitate high-performance parallel computing Utilizes CUDA version 7.5, NVIDIA's software development tool created specifically for massively parallel environments Contains new and updated case studies Includes coverage of newer libraries, such as CuDNN for Deep Learning
Determinants in Canadian Health Care Workers of the Decision to Withdraw Life Support From the Critically Ill (1995)

Objective. —To examine the attitudes of health care workers regarding the withdrawal of life support. Design. —Cross-sectional survey. Participants. —Attending staff, house staff, and intensive care unit (ICU) nurses in 37 Canadian university-affiliated hospitals. Main Outcome Measures. —Health care workers' ratings of the importance of 17 factors considered in the decision to withdraw life support, and their ratings of five levels of care ranging from comfort measures to intensive care in two of 12 different clinical scenarios. Results. —We surveyed 1361 respondents (149 of 167 potentially eligible ICU attending staff, 142 of 173 ICU house staff, and 1070 of 1455 ICU nurses, with response rates of 89%, 82% and 74%, respectively). The most important factors were likelihood of surviving the current episode, likelihood of long-term survival, premorbid cognitive function, and age of the patient. In choosing the level of care for the patient scenarios, the same option was chosen by more than 50% of respondents in only one of 12 scenarios; opposite extremes of care were chosen by more than 10% of the respondents in eight of 12 scenarios. Respondent characteristics affecting choices included the number of years since graduation, the city and province in which they worked, the number of beds in their ICU, and their assessment of the likelihood that they would withdraw life support in comparison with their colleagues (P Conclusions. —While ICU health care workers consistently identify a number of patient factors as important in decisions to withdraw care, there is extreme variability, which may be explained in part by the values of individual health care providers. (JAMA. 1995;273:703-708)
Effective research writing (2011)

Good writing isn’t forged by magic or hatched out of thin air. Good writing happens when human beings take particular steps to take control of their sentences, to make their words do what they want them to do.
ChemInform Abstract: Model Reactions of Molybdo‐Reductase. A Novel and Highly Efficient Reduction of Nitrobenzene to Aniline Catalyzed by a Molybdenum‐ Mediated Oxygen Atom Transfer Reaction. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.