gebhart/patrepeval huggingface dataset:
Contrasting Effects of Leptin on Food Anticipatory and Total Locomotor Activity (2011)

Obese, leptin deficient obob mice have profoundly decreased activity and increased food seeking behavior. The decreased activity has been attributed to obesity. In mice, we tested the hypothesis that leptin increases total locomotor activity but inhibits food anticipatory activity. We also sought to determine if leptin induced increases in total locomotor activity are independent of changes in body weight and obesity. We studied obob mice and also created a novel transgenic mouse where leptin is over-expressed in a tetracycline-off system and can be abruptly and non-invasively suppressed by doxycycline within few hours. The studies were performed using two independent behavioral assays: home cage activity (HCA) and running wheel activity (RWA). Systemic administration of leptin (150 ng/hr) to obob mice produced a 122%±30% (mean ± SEM) increase (p≤0.01) in locomotor activity within 2 days In addition, cerebroventricular administration of leptin (5 ng/hr) also produced an early and progressive increase in total locomotor activity beginning on the 1st day (+28±8%; p≤0.05) and increasing to +69±23% on day 3 without a decrease in body weight during this time. The increase in activity was restricted to the dark phase. Conversely, in a tet-off transgenic obob mouse line, acute leptin suppression reduced spontaneous locomotor activity. To further define activities that are leptin regulated, we assayed food anticipatory activity (FAA) and found that it was markedly augmented in obob mice compared to wild type mice (+38±6.7 in obob vs +20±6.3% in wild type at peak; mean ± SEM; p≤0.001) and abolished by leptin. Although melanocortin-3 receptors (MC3R) reportedly mediate FAA, we found augmented FAA and preserved inhibitory effects of leptin on FAA in MC3R-/-obob mice. In summary, this study demonstrates that total activity and FAA are regulated independently by leptin. Leptin, acting in the central nervous system and at physiologic levels, produces early increases in locomotor activity before substantial weight loss. In contrast, leptin suppresses augmented food anticipatory activity in obob mice.
Distributed Algorithms for the Placement of Network Services (2010)

Abstract — Network services play an important role in the Internet today. They serve as data caches for websites, servers for multiplayer games and relay nodes for Voice over IP (VoIP) conversations. While much research has focused on the design of such services, little attention has been focused on their actual placement. These services are often located on nodes in the network itself, making these nodes supernodes. Typically supernodes are selected in either a proprietary or ad hoc fashion, where a study of this placement is either unavailable or unnecessary. In this work we develop distributed algorithms to assign nodes the role of a supernode. We first build on prior work by modifying an existing assignment algorithm and implementing it in a distributed system called Supernode Placement in Overlay Topologies (SPOT). New algorithms are then developed to assign nodes the supernode role. 1.
Abnormal vitamin b6status in rheumatoid cachexia association with spontaneous tumor necrosis factor α production and markers of inflammation (1995)

PLP levels are reduced in patients with RA. This reduction is associated with TNF alpha production by PBMC.
Impact of Operational Parameters on Optimum Performance of SOA-Based Differential-Mode Wavelength Converters (2007)

This letter investigates the interdependencies of the operational parameters of semiconductor-optical-amplifier-based differential mode wavelength converters. Through numerical simulations, we relate the optimum device response to temporal phase variations in the two arms of the Mach-Zehnder interferometer and propose design guidelines for enhanced performance. Fundamental differences between the delayed-interference signal converter and differential cross-phase-modulation configurations are highlighted indicating that dynamic optimization of the phase-bias based on the input signal's extinction ratio can improve the regenerative performance.
Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus BMI156-14F1. II. Structure determination of leuhistin. (1991)

Leuhistin, a new inhibitor of aminopeptidase M, has been isolated from the culture broth of Bacillus laterosporus BMI156-14F1. The structure of leuhistin was determined by NMR studies. X-Ray and chemical analysis confirmed the absolute structure to be (2R,3S)-3-amino-2-hydroxy-2-(1H-imidazol-4-ylmethyl)-5-methylhe xanoic acid.
Multi-Layer Service Provisioning Over Resilient Software-Defined Partially Disaggregated Networks (2019)

The need of introducing interoperability in the transport network segment has motivated the emergence of several open initiatives and standardization efforts for the development of different interfaces to allow Software Defined Network (SDN) controllers manage and control the network devices. Optical disaggregation in particular aims the introduction of standard device-level interfaces in the optical terminals and line-systems to `open' them from vendor lock-in situations, allowing an interoperable ecosystem in the optical network's transport segment. In this article, it is firstly presented the Software Defined Transport Network (SDTN) architecture, as the control and management framework to build a L0-L3 multi-layer, multi-technology transport network, enabling end-to-end network service delivery. Later, we introduce the partially disaggregated network architecture proposed, including the technical assessment of the topology discovery and resilience service provisioning use cases, by providing a low-level description of the information models employed and the translation between models. To conclude, a proof-of-concept of multi-layer service provisioning over resilient disaggregated multi-vendor testbed is presented, including the results obtained in the experimental demonstration presented in last 2019 Optical Fiber Conference (OFC).
High-Speed Radio-on-Free-Space Optical Mobile Fronthaul System for Ultra-Dense Radio Access Network (2020)

We present a transmission of radio signals in high-frequency band over a seamless fiber–FSO system for ultra-dense radio access network. We successfully transmitted 80-Gb/s and 40-Gb/s 2×2 MIMO FBMC-OQAM signal in the 90-GHz band over the DL and UL direction.
Supplementary Table 3 from Rationale and Preclinical Efficacy of a Novel Anti-EMP2 Antibody for the Treatment of Invasive Breast Cancer (2023)

&lt;p&gt;PDF - 51K, Supplementary Table 3. Expression levels of EMP2 in triple negative breast cancer.&lt;/p&gt;
A comparison of transient heat pump cycle models using alternative flow descriptions (2015)

This article compares the effects of two different refrigerant flow modeling assumptions on the transient performance of vapor-compression heat pump cycles. This comparison is done on a dynamic system-level model of a flash tank vapor injection cycle that includes finite-volume heat exchanger models. The effect of the flow assumptions and specific slip ratio correlations on both the equilibrium operating point and the transient behavior of the cycle are demonstrated through both simulations and experiments. It is shown that equivalent simulations with different slip ratio correlations each have different equilibrium mass inventories and that some aspects of the dynamic system behavior, such as the suction superheat or pressure transients, exhibit significant differences both in simulations and in comparison to experimental data.
ChemInform Abstract: Rearrangement of Nitropyridylidenemalonate 1‐Oxides. A Novel Method for the Synthesis of Aminopyridine Derivatives. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
NCHRP REPORT 350 TEST 3-11 OF THE TEXAS TYPE T6 BRIDGE RAIL (1998)

The Texas Type T411 Bridge Rail is a concrete beam-and-posts system that was developed under a previous Texas Transportation Institute (TTI) study performed for Texas Department of Transportation (TxDOT). The Texas Type T411 was previously crash tested and approved under NCHRP Report 230 guidelines. However, with the adoption of NCHRP Report 350, the bridge rail needed to be reevaluated using the 2000-kg pickup truck. The report presents the details and results of the full-scale crach test on the Texas Type T411 Bridge Rail with the 2000-kg pickup truck traveling at 100 km/h and 25 degrees to evaluate performance at test level three. According to the specifications set for NCHRP Report 350 test designation 3-11, the Texas Type T411 Bridge Rail met all requirements except occupant risk. Significant occupant compartment deformation occurred on the center and right side of the vehicle. This deformation was judged to have the potential to cause serious injury.
Sonochemical Coating of Textiles with Hybrid ZnO/Chitosan Antimicrobial Nanoparticles (2014)

Textiles are good substrates for growth of microorganisms especially under moisture and temperature conditions found in hospitals. Microbial shedding from the body occurs continuously at contact of the patient with textile materials used in medical practices, contributing to the occurrence of hospital acquired infections. Thus, the use of efficient antimicrobial textiles is necessary to prevent the transfer of pathogens and the infection incidence. In this work, hybrid antimicrobial coatings were generated on cotton fabrics by means of a one-step simultaneous sonochemical deposition of ZnO nanoparticles (NPs) and chitosan. The process was further optimized in terms of reagents concentration and processing time in order to improve the antibacterial properties of the fabric and ensure their biocompatibility. The highest antibacterial activity of the fabrics against two medically relevant bacterial species was achieved in a 30 min sonochemical coating process using 2 mM ZnO NPs suspension. When chitosan was simultaneously deposited with the same amount of ZnO, the obtained hybrid NPs coating displayed higher by 48 and 17% antibacterial activity against Staphylococcus aureus and Escherichia coli, respectively. The presence of biopolymer also improved the durability of the antimicrobial effect of the coatings by 21% for Staphylococcus aureus and 40% for Escherichia coli, evaluated after applying multiple washing cycles at hospital laundering regimes. Finally, 87% biocompatibility improvement supported by fibroblast viability was observed for the hybrid ZnO/chitosan coating compared to the steady decrease of cells viability over one week in contact with the fabrics coated with ZnO alone.
A Bi-directional wireless power system with integrated magnetics (2017)

Electric vehicles (EVs) are becoming increasingly popular as a mean of future transportation. A wireless interface between EV and the utility grid, with a bi-directional wireless power technology (BD-WPT), has several advantages, such as safety, convenience and physical isolation. However, physical misalignment between the magnetic couplers of BD-WPT systems used in EVs are unavoidable and introduces variations in key parameters, thus, significantly increasing losses and affecting the power throughput. This paper proposes a new BD-WPT topology where the series inductors of the LCL networks are integrated in to the magnetic couplers to improve system performance under misalignment. Both DD and bi-polar type integrated magnetics are implemented and compared. A mathematical model is developed to investigate the behavior and the sensitivity to variation in parameters of the system. The results indicate that, in comparison to a benchmark LCL tuned BD-WPT system, proposed system results in up to 20% more in power throughput when pads are misaligned. Moreover, the proposed system with bi-polar pads has an efficiency of 95.5% while the system with DD pads has a slightly lower efficiency of 93.5%.
DVB-T signal in cable TV network: advantages and limitations (2002)

In this paper, we study the quality of the terrestrial digital video broadcasting (DVB-T) transmission over the cable TV network. Usually, when terrestrial digital TV signals are distributed in the cable TV network a conversion is needed in the head-end, from DVB-T (OFDM) to DVB-C (single carrier). In this work we study the possibility of using the DVB-T signal without any conversion. At first, a simple model for the channel is designed taking into account the main impairments. Secondly, the performance of the DVB-T signal is simulated and compared to that of digital cable TV standard DVB-C that is based on single carrier technique. The comparison is based on the bit error ratio that each system can achieve, in the same channel environment. Channel interference problems are also simulated.
Dynamics of Liquid Crystalline Side-Chain Poly(Vinyl Ether)s (1996)

Abstract Segmental mobility between 100 and 350 K is reported for a series of mesomorphic side-chain poly(vinyl ether)s with 4–11 methylene carbon atoms in the spacer and phenyl benzoate and stilbenyloxy groups used as mesogens. A glass-rubber transition (α) appears in the vicinity of 300 K. Three subglass processes, referred to as β, 7, and δ obey the Arrhenius and Cole-Cole equations. The δ-process is present only in polymers with flexible and dielectrically active tail groups, e.g., in polymers with an ethoxy group, in which case the process can be assigned to torsion about the pendant phenyl-carbon-ether-oxygen bond. The activation energy (35 ± 5 kJ ·−1) of the β-process is insensitive to the morphology and is assigned to local motions within the spacer. The activation energy of the β-process varied considerably among the studied polymers (60 to 126 kJ·mol−1). The absence of the β-process in the stilbenyloxy polymer suggests that this process is due to reorientation of the carboxylic group in the phenyl benzoate moiety. The relaxation strength associated with the β-process passes through a maximum as the spacer length increases. In a polymer with a short spacer group, the participating carboxyl group is not able to reorient completely. In polymers with longer spacer groups, reorientation is more complete but the concentration of active mesogens is lower. Phenyl-benzoate polymers with 11 carbon atoms in the spacer, with different tacticities, exhibited the same dielectric relaxation behavior.
Green challenges: student perspectives from the 2004 ACS-PRF Summer School on Green Chemistry (2005)

Participants in the American Chemical Society-Petroleum Research Fund (ACS-PRF) Summer School on Green Chemistry discuss the topics covered and lessons learned during the week-long summer school held July 31 through August 7, 2004, at Carnegie Mellon University. An outline of the program is accompanied by a discussion of the challenges and needs of the field of green chemistry as seen by the participants. These include further education of the public as well as members of the scientific community, thorough research and rigorous publication standards, and the formation of a cooperative and collaborative group of researchers.
NH2-Terminal Sequence of the Clostripain and NBS Peptides of Streptococcal M5 Protein Purified in One Step by HPLC (1982)

M protein, the antiphagocytic surface molecule of the Group A streptococcus is a type specific, imiriuno logic ally diverse molecule. We have shown that the molecular characteristics of M proteins and the seven residue periodicity within their partial sequences are similar to those found in tropomyosin suggesting an alpha-helical coiled-coil structure for these molecules (1, 2). To determine if the seven residue periodicity extends throughout the molecule, sequence studies have been undertaken on a biologically active 19,000 dalton M protein fragment, namely Pep M5, isolated by limited proteolysis of the type 5 streptococci with pepsin (3).
Figure S1 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery (2023)

&lt;p&gt;The effect of combination PDP and nal-IRI on tumour growth inhibition is synergistic in orthotopic MIA PaCa-2 mouse model.&lt;/p&gt;
Role of adjuvant imatinib dose in radically resected GIST harboring KIT exon 9 mutations. (2020)

11533 Background: Gastrointestinal stromal tumors (GIST) with a driver mutation in KIT exon 9 (Ex9) represent about 10% of all newly diagnosed cases. In the metastatic setting, Ex9-mutated GIST patients benefit from higher doses of imatinib (800 mg/day vs standard 400 mg/day). The additional therapeutic benefit from a higher dose of imatinib in the adjuvant setting in this molecular subgroup has not been confirmed. Methods: We retrospectively identified 105 patients (pts) with resected Ex9-mutated GIST treated with adjuvant imatinib (800 mg/day or 400 mg/day) in 15 different European centers. Disease-Free Survival (DFS) and Imatinib Failure-Free Survival (IFFS) were calculated and analyzed according to the daily dose of imatinib and relevant clinical and pathological variables. Kaplan–Meier curves were used to estimate survival in univariate analyses, and the log-rank test was used to compare the groups. Hazard Ratios (HR) with 95% confidence intervals (CI) were calculated using a univariable Cox model. A multivariate Cox regression model was also performed. Results: Of the 105 pts who met the inclusion criteria, 69 (65.7%) were treated with 400 mg/day and 36 (34.3%) with 800 mg/day. The risk score (AFIP-Miettinen criteria) between the two dose groups was not statistically different (P = 0.29). Median DFS was 73.0 months (mo) in the 400 mg/day group and 61.9 mo in the 800 mg/day group (HR = 0.82, 95% CI: 0.47-1.47; P = 0.50). Median IFFS was 156.8 mo in the 400/day mg group and 117.4 mo in the 800 mg/day group (HR = 0.66, 95% CI: 0.34-1.29; P = 0.19). In a multivariable analysis, the variables statistically associated with DFS were mitotic count, the longest tumor diameter and the duration of adjuvant therapy. Mitotic count and the duration of adjuvant therapy were also associated with IFFS. Importantly, the daily imatinib dose was not associated with survival in either analysis (Table). Conclusions: This is the largest reported cohort of pts with Ex9-mutated GIST treated with either the 400 mg/day or the 800 mg/day dose of adjuvant imatinib. Although retrospective in nature, the data confirm the prognostic value of mitotic count and suggest that patients with Ex9-mutated GIST derive no additional survival benefit from the 800 mg/day dose. [Table: see text]
DRY-RELEASED POST-CMOS COMPATIBLE CONTOUR-MODE ALUMINUM NITRIDE MICROMECHANICAL RESONATORS FOR VHF APPLICATIONS (2004)

This paper reports experimental results on a new class of dryreleased, post-CMOS compatible, contour-mode aluminum nitride resonators spanning a frequency range from 23 MHz to 225 MHz showing high quality factors both in vacuum (Q max =5,830 at 43.26 MHz) and air (Q air =3,700), and low motional resistance (~600 at 89 MHz).
In-RDBMS inverted indexes revisited (2014)

Every major open-source and commercial RDBMS offers some form of support for full-text search using inverted indexes. When providing this support, some developers have implemented specialized indexes that adapt techniques from the Information Retrieval (IR) community to work in a database setting, while others have opted to rely on the standard relational query engine to process inverted index lookups. This choice is an important one, since the storage formats and algorithms used can vary greatly between a specialized index and a relational index, but these alternatives have not been thoroughly compared in the same system. Our work explores the differences in implementation and performance of three representative environments for an in-RDBMS inverted index: an in-RDBMS IR engine, a row-oriented relational query engine, and a column-oriented relational query engine. We found that a specialized IR engine integrated into the RDBMS can provide more than an order of magnitude speedup over both the row- and column-oriented relational query engines for conjunctive and phrase queries. For warm queries, this advantage is largely algorithmic, and we show that by using ZigZag merge join to accelerate conjunctive and phrase query processing, relational inverted indexes can provide performance comparable to a specialized in-RDBMS IR engine with no change to the underlying storage format. Compression and index format, in contrast, have more impact on cold queries, where the IR and column-oriented engines are able to outperform the row-oriented engine, even with ZigZag merge join.
Biomechanical Behavior of Extensively Restored Premolars: Cusp Deformation, Marginal Integrity, and Fracture Resistance. (2015)

The low-shrinkage composite VD performed better in restoring extensively destroyed premolars than did Z250.
Secretion of atypical protein substrates by the ESAT‐6 Secretion System of Staphylococcus aureus (2013)

Staphylococcus aureus encodes the specialized ESAT-6 Secretion System (ESS). EsxA and EsxB are secreted by the ESS pathway, and share sequence features of ESAT-6 and CFP-10 of the Type VII Secretion System (T7SS) of Mycobacterium tuberculosis. Unlike ESAT-6 and CFP-10, EsxA and EsxB do not interact. Instead, EsxB associates with a novel substrate, EsxD, and EsxA dimerizes with itself or EsxC (EsaC). Unlike EsxA and EsxB, EsxC and EsxD do not share obvious sequence features of WXG100 proteins nor PE/PPE and Esp families of proteins, all of which belong to the pfam EsxAB clan of mycobacterial T7SS. EsxD carries the C-terminal motif YxxxD/E that has been proposed to target T7 substrates for secretion in mycobacteria. Here, we find that deletion, but not amino acid substitutions, in this motif prevent secretion of EsxA and EsxC but not EsxB or EsxD. This is unlike the genetic inactivation of esxA, esxB, esxC or esxD that leads to loss of secretion of all four substrates. Thus, substrate secretion can be uncoupled by deleting the last six amino acids of EsxD. The physical association of EsxC and EsxD with canonical WXG100 proteins suggests that these proteins belong to the EsxAB clan.
The role of tosylhydrazone stereochemistry upon the regiospecificity of olefin formation (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe role of tosylhydrazone stereochemistry upon the regiospecificity of olefin formationW. G. Dauben, G. T. Rivers, and W. T. ZimmermanCite this: J. Am. Chem. Soc. 1977, 99, 10, 3414–3420Publication Date (Print):May 1, 1977Publication History Published online1 May 2002Published inissue 1 May 1977https://pubs.acs.org/doi/10.1021/ja00452a038https://doi.org/10.1021/ja00452a038research-articleACS PublicationsRequest reuse permissionsArticle Views369Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts