gebhart/patrepeval huggingface dataset:
Serpin-positive Bifidobacterium breve CNCM I-5644 improves intestinal permeability in two models of irritable bowel syndrome (2022)

Probiotic supplementation can help to mitigate the pathogenesis of irritable bowel syndrome (IBS) by reinforcing the intestinal barrier, and reducing both inflammation and proteolytic activity. Here, a combination of in vitro tests was performed on 33 Bifidobacterium strains as probiotic candidates for IBS. In addition to the classical tests performed, the detection of the serine protease inhibitor (serpin) enzyme capable of decreasing the high proteolytic activity found in IBS patients was included. Three serpin-positive strains were selected: Bifidobacterium breve CNCM I-5644, Bifidobacterium longum subsp. infantis CNCM I-5645 and B. longum CNCM I-5646 for their immunomodulation properties and protection of intestinal epithelial integrity in vitro. Furthermore, we found that B. breve CNCM I-5644 strain prevented intestinal hyperpermeability by upregulating Cingulin and Tight Junction Protein 1 mRNA levels and reducing pro-inflammatory markers. The ability of CNCM I-5644 strain to restore intestinal hyperpermeability (FITC-dextran) was shown in the murine model of low-grade inflammation induced by dinitrobenzene sulfonic acid (DNBS). This effect of this strain was corroborated in a second model of IBS, the neonatal maternal separation model in mice. Altogether, these data suggest that serpin-positive B. breve CNCM I-5644 may partially prevent disorders associated with increased barrier permeability such as IBS.
PtBi, PtCu and PtBiCu nanoclusters grown in a magnetron based gas aggregation source (2019)

International audience
A Synchronization Technique for Bidirectional IPT Systems (2011)

Bidirectional inductive power transfer (IPT) systems are attractive for applications such as electric vehicles and vehicle-to-grid systems which preferably require “contactless” and two-way power transfer. However, in contrast to unidirectional IPT systems, bidirectional IPT systems require more sophisticated control strategies to control the power flow. An indispensible component of such control strategies is the robust and accurate synchronization between the primary- and pickup-side converters, without which the transfer of real power in any direction cannot be guaranteed. This paper proposes a novel technique that synchronizes converters on both the primary and pickup sides of bidirectional IPT systems. The technique uses an auxiliary winding, located on the pickup side, to produce a synchronizing signal which, in turn, can be utilized to regulate the real power flow. This paper also presents a mathematical model for the proposed technique and investigates its sensitivity for component tolerances. The viability of the technique, which is applicable to both single- and multiple-pickup IPT systems, is demonstrated through both simulations and experimental results of a 1-kW prototype bidirectional IPT system.
Iminosugars as Therapeutic Agents: Recent Advances and Promising Trends (2011)

For the purpose of this article, iminosugars are polyhydroxylated secondary and tertiary amines in which the molecules resemble monosaccharide sugars in which the ring oxygen is replaced by the nitrogen. The bicyclic structures may biologically resemble disaccharides. Very few iminosugars have been available up to now for evaluation of their pharmaceutical applications. The early compounds were discovered and selected for study due to glycosidase inhibition, which is now known to not be necessary for pharmacological activity and may cause off-target effects. Glyset® and Zavesca®, derived from the glucosidase-inhibiting natural product 1-deoxynojirimycin, are the first two examples of iminosugar drugs. Since the discovery of this first generation, many new natural products have been identified with a wide range of biological activities but few are widely available. Among the biological properties of these compounds are good oral bioavailability and very specific immune modulatory and chaperoning activity. Although the natural products from plants and microorganisms can have good specificity, modifications of the template natural products have been very successful recently in producing bioactive compounds with good profiles. The field of iminosugars continues to open up exciting new opportunities for therapeutic agent discovery and offers many new tools for precisely modifying carbohydrate structures and modulating glycosidase activity in vivo. Current efforts are directed towards a greater range of structures and a wider range of biochemical targets.
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors (2015)

Novel therapeutic approaches are urgently required for multiple myeloma (MM). We used a phenotypic screening approach using co-cultures of MM cells with bone marrow stromal cells to identify compounds that overcome stromal resistance. One such compound, BRD9876, displayed selectivity over normal hematopoietic progenitors and was discovered to be an unusual ATP non-competitive kinesin-5 (Eg5) inhibitor. A novel mutation caused resistance, suggesting a binding site distinct from known Eg5 inhibitors, and BRD9876 inhibited only microtubule-bound Eg5. Eg5 phosphorylation, which increases microtubule binding, uniquely enhanced BRD9876 activity. MM cells have greater phosphorylated Eg5 than hematopoietic cells, consistent with increased vulnerability specifically to BRD9876’s mode of action. Thus, differences in Eg5-microtubule binding between malignant and normal blood cells may be exploited to treat multiple myeloma. Additional steps are required for further therapeutic development, but our results indicate that unbiased chemical biology approaches can identify therapeutic strategies unanticipated by prior knowledge of protein targets.
Study of light scattering and transparency in human edematous corneas and application to corneal grafts (2011)

The optical properties of the cornea have been a research subject of great interest for many years. Several early theories have been put forward to explain with more or less success the optical transparency of this tissue, but it was not until Maurice demonstrated in a very elegant way during the 50s that this optical transparency could be explained by the regular ultrastructure of the cornea. When becoming edematous, the cornea’s ultrastructure is perturbed and the tissue becomes a strongly scattering medium.
Group Velocity Engineering in Silicon Nanophotonic Circuits (2005)

We report an over 300-fold reduction of the group velocity in photonic crystal waveguides measured with integrated Mach-Zehnder interferometer. We show fast (100ns) and efficient (2mW electric power) tunability of the group velocity with an integrated micro-heater.
A New Double-Lumen Tube Adapter (1980)

Tanguturi, Satyanarayana MD; Capan, Levon M. MD; Patel, Katie MD; Turndorf, Herman MD Author Information
Real-time in vivo optical coherence microscopy (2001)

Summary form only given. In-vivo confocal microscopy has been proposed/sup 1/ and demonstrated as a powerful tool for noninvasive imaging permitting optical sectioning in bulk biological samples due to its strong axial discrimination. Depending on the numerical aperture (NA), axial and lateral resolutions of several micrometers are obtainable. The maximal depth of imaging is limited to several hundred microns in highly scattering tissues such as the skin, however, by multiple scattered photons arising from out-of-focus-regions of the sample. Optical coherence microscopy (OCM) is a combination of confocal microscopy and optical coherence tomography (OCT). In OCM, the coherence gate of OCT is overlapped with the confocal gate of confocal microscopy to provide increased rejection of multiply scattered photons and therefore extend the usable depth range.
Investigation of Hydrogenated Amorphous Silicon Germanium Fabricated under High Hydrogen Dilution and Low Deposition Temperature Conditions for Stable Solar Cells (1998)

The effects of hydrogen dilution of up to 54:1 (=H 2 :SiH 4 ) on hydrogenated amorphous silicon germanium (a-SiGe:H) were investigated while keeping the optical gap ( E opt ) constant. It was found that deterioration of the film properties of a-SiGe:H due to a decrease in substrate temperature ( T s ) can be compensated by the high hydrogen dilution method. As T s decreases from 230°C to 180°C, the high photoconductivity [∼1×10 -5 (Ω·cm) -1 ] and low silicon dihydride content (∼1 at.%) of a-SiGe:H can be maintained with a high hydrogen dilution ratio of 54:1, although these properties deteriorate with the conventional low hydrogen dilution ratio of 2.5:1. Probably, hydrogen radicals supply the energy required for the surface reaction during a-SiGe:H deposition which is lost when T s is decreased. This tendency is useful for solar cell fabrication, especially for superstrate-type a-Si/a-SiGe tandem solar cells, because the decrease in the deposition temperature of a-SiGe:H for the bottom photovoltaic layer can reduce damage to the underlying layers caused by a high deposition temperature. As a result of applying this technique to the fabrication process of an a-Si/a-SiGe stacked solar cell submodule (area: 1200 cm 2 ), the world's highest stabilized efficiency of 9.5% (light-soaked and measured at JQA) was achieved.
Opossum colonic mucosa contains uroguanylin and guanylin peptides (1996)

Uroguanylin and guanylin are structurally related peptides that activate an intestinal form of membrane guanylate cyclase (GC-C). Guanylin was isolated from the intestine, but uroguanylin was isolated from urine, thus a tissue source for uroguanylin was sought. In these experiments, uroguanylin and guanylin were separated and purified independently from colonic mucosa and urine of opossums. Colonic, urinary, and synthetic forms of uroguanylin had an isoelectric point of approximately 3.0, eluted from C18 reverse-phase high-performance liquid chromatography (RP-HPLC) columns at 8-9% acetonitrile, elicited greater guanosine 3', 5'-cyclic monophosphate (cGMP) responses in T84 cells at pH 5.5 than pH 8, and were not cleaved and inactivated by pretreatment with chymotrypsin. In contrast, colonic, urinary, and synthetic guanylin had an isoelectric point of approximately 6.0, eluted at 15-16% acetonitrile on C18 RP-HPLC columns, stimulated greater cGMP responses in T84 cells at pH 8 than pH 5.5, and were inactivated by chymotrypsin, which hydrolyzed the Phe-Ala or Try-Ala bonds within guanylin. Uroguanylin joins guanylin as an intestinal peptide that may participate in an intrinsic pathway for cGMP-mediated regulation of intestinal salt and water transport. Moreover, uroguanylin and guanylin in urine may be derived from the intestinal mucosa, thus implicating these peptides in an endocrine mechanism linking the intestine with the kidney.
Efficient Top‐Gate, Ambipolar, Light‐Emitting Field‐Effect Transistors Based on a Green‐Light‐Emitting Polyfluorene (2006)

Bright, ambipolar, light-emitting polymer field-effect transistors in a bottom-contact/top-gate structure using poly(9,9-di-n-octylfluorene-alt- benzothiadiazole) (F8BT) as a green-emitting semiconductor show balanced hole and electron mobilities, depending on the polymer dielectric. The emission zone, observed as a bright line in the figure, is well defined and can be moved through the channel.
Formation of Palladium Bis(amine) Complexes from Reaction of Amine with Palladium Tris(o-tolyl)phosphine Mono(amine) Complexes (1996)

Palladium mono(benzylamine) complexes Pd[P(o-tolyl)3](p-C6H4CMe3)[H2NBn]X (X = Cl (7), Br (8), I (14)) react reversibly with benzylamine in CDCl3 at 25 °C via P(o-tolyl)3 displacement to generate the corresponding bis(amine) derivatives trans-Pd(p-C6H4CMe3)[H2NBn]2X (X = Cl (17), Keq = 0.18 ± 0.02; Br (16), Keq = 0.14 ± 0.01; I (18), Keq = 0.10 ± 0.01). Complexes 16−18 were isolated from reaction of the palladium aryl halide dimers {Pd[P(o-tolyl)3](p-C6H4CMe3)(μ-X)}2 (X = Cl (4), Br (5), I (6)) and excess benzylamine as the corresponding mono(benzylamine) solvate Pd(p-C6H4CMe3)[H2NBn]2X·H2NBn (X = Br (16·H2NBn), Cl (17·H2NBn), I (18·H2NBn)). IR and 1H NMR spectroscopy of 16·H2NBn indicated the presence of N−H···X (X = N, Br, Pd) hydrogen bonds in both the solid state and solution. The equilibrium constant for the formation of 16 and P(o-tolyl)3 from 8 and benzylamine ranged from 0.066 ± 0.005 in CD2Cl2 to 3.6 ± 0.3 in THF-d8 and in C6D6 ranged from 0.90 ± 0.07 at 25 °C to 0.44 ± 0.04 at 77 °C (ΔG°298 K = 0.06 ± 0.01 kcal mol-1; ΔH°298 K = −2.8 ± 0.1 kcal mol-1; ΔS°298 K = −9 ± 1 eu). The equilibrium constants for the formation of the bis(amine) complexes Pd(p-C6H4CMe3)[amine]2Br from the reaction of Pd[P(o-tolyl)3](p-C6H4CMe3)[amine]Br and amine decreased in the order phenethylamine ≈ cyclohexylamine ≈ benzylamine ≈ (4-methylbenzyl)amine ≫ piperidine ≫ N-methylbenzylamine.
Preparation of Macrocyclic (2014)

The first examples of catalyst-controlled stereoselective macrocyclic ring-closing metathesis reactions that generate Z-enoates as well as (E,Z)- or (Z,E)-dienoates are disclosed. Reactions promoted by 3.0–10 mol % of a Mo-based monoaryloxide pyrrolide complex proceed to completion within 2–6 h at room temperature. The desired macrocycles are formed in 79:21 to >98:2 Z/E selectivity; stereoisomerically pure products can be obtained in 43–75% yield after chromatography. Utility is demonstrated by application to a concise formal synthesis of the natural product (+)-aspicilin.
Stereoregular P(MMA)‐clay nanocomposites by metallocene catalysts: In situ synthesis and stereocomplex formation (2007)

Abstract This contribution reports the synthesis and characterization of stereochemically controlled, as well as crystalline stereocomplex, P(MMA)‐clay nanocomposites using metallocene complexes and alane‐intercalated clay activators. The ligand elimination and exchange reactions involving Lewis acids E(C 6 F 5 ) 3 (E = Al, B) and an organically modified montmorillonite clay were employed to synthesize the alane‐intercalated clay activators. When combined with dimethyl metallocenes of various symmetries, these clay activators brought about efficient MMA polymerizations leading to in situ polymerized, stereochemically controlled P(MMA)‐intercalated clay nanocomposites. The most noticeable thermal property enhancement observed for the clay nanocomposite P(MMA), when compared with the pristine P(MMA) having similar molecular weight and stereomicrostructure, has a considerable increase in T g (≥10 °C). Mixing of dilute THF solutions of two diastereomeric nanocomposites in a 1:2 isotactic to syndiotactic ratio, followed by reprecipitation or crystallization procedures, yielded unique double‐stranded helical stereocomplex P(MMA)‐clay nanocomposites with a predominantly exfoliated clay morphology. Remarkably, the resulting crystalline stereocomplex P(MMA) matrix is resistant to the boiling‐THF extraction and its clay nanocomposites exhibit high T m of 201 to 210 °C. Furthermore, the stereocomplex P(MMA)‐clay nanocomposite shows a one‐step, narrow decomposition temperature window and a single, high maximum rate decomposition temperature of 377 °C. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 2581–2592, 2007
Morphology of Vergina Star 16-Arm Block Copolymers and Scaling Behavior of Interfacial Area with Graft Point Functionality (1997)

The morphological behavior of three well-defined miktoarm star block copolymers having 16 arms/molecule was characterized using transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), and small-angle neutron scattering (SANS) techniques. The molecules, called Vergina stars, have 8 arms of polyisoprene and 8 arms of polystyrene radiating from a single junction point. The samples, with polystyrene volume fractions of 0.37, 0.44, and 0.47 and total molecular weights ranging from 330 000 to 894 000, were all found to microphase separate into lamellar morphologies. In this respect all three samples, in agreement with theory, behave in the same way as linear diblock copolymers of the same relative volume fractions. Incorporating results from previous studies in the literature of miktoarm block copolymers containing trifunctional and tetrafunctional branch points, as well as the new Vergina star data, the scaling behavior of the area per junction versus junction functionality was investigated.
Direct Observation of Counterions Bound to a Charged Surfactant Monolayer by Sum-Frequency Vibrational Spectroscopy (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect Observation of Counterions Bound to a Charged Surfactant Monolayer by Sum-Frequency Vibrational SpectroscopyDavid C. Duffy, Robert N. Ward, Paul B. Davies, and Colin D. BainCite this: J. Am. Chem. Soc. 1994, 116, 3, 1125–1126Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/ja00082a042https://doi.org/10.1021/ja00082a042research-articleACS PublicationsRequest reuse permissionsArticle Views198Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
In Vivo Photoacoustic Imaging of Anterior Ocular Vasculature: A Random Sample Consensus Approach (2017)

Visualizing ocular vasculature is important in clinical ophthalmology because ocular circulation abnormalities are early signs of ocular diseases. Photoacoustic microscopy (PAM) images the ocular vasculature without using exogenous contrast agents, avoiding associated side effects. Moreover, 3D PAM images can be useful in understanding vessel-related eye disease. However, the complex structure of the multi-layered vessels still present challenges in evaluating ocular vasculature. In this study, we demonstrate a new method to evaluate blood circulation in the eye by combining in vivo PAM imaging and an ocular surface estimation method based on a machine learning algorithm: a random sample consensus algorithm. By using the developed estimation method, we were able to visualize the PA ocular vascular image intuitively and demonstrate layer-by-layer analysis of injured ocular vasculature. We believe that our method can provide more accurate evaluations of the eye circulation in ophthalmic applications.
Bond Behavior of Prestressed CFRP Strips-to-Concrete Joints Using the EBROG Method: Experimental and Analytical Evaluation (2022)

Fiber-reinforced polymer (FRP) composites are widely employed as externally bonded reinforcement (EBR) systems for strengthening reinforced concrete members. More recently, a new technique, referred to as externally bonded reinforcement on grooves (EBROG), has been proposed, which is based on using a number of grooves throughout the concrete substrate to enhance the bond strength between the FRP composite and concrete. This study investigates the influence of groove depth on the resulting debonding process that can be observed in prestressed carbon FRP strips. To do so, prestressing force release tests were conducted on a series of EBR and EBROG FRP strips bonded to concrete specimens. Test results demonstrated that the fracture process leading to debonding of the EBROG specimens developed in a significantly different manner with respect to the case of EBR specimens. Specifically, fractures ran through deeper layers of concrete as the grooves became deeper. Numerical analyses are also proposed to scrutinize the actual bond–slip law characterizing both EBR and EBROG specimens. It was shown that a trilinear bond–slip law is appropriate for simulating the interface behavior in EBROG specimens.
Preliminary experimental scaling of the helical mirror confinement effectiveness (2020)

The paper presents experimental results from the SMOLA device that is the first facility with a helical mirror section of the magnetic field. This device is built in the Budker Institute of Nuclear Physics for the verification of the helical mirror confinement idea that is the recently introduced technique of the active control of axial losses from a confinement zone. Theory predicts that with rotating plasma, a helical mirror will provide suppression of the axial plasma flow and, simultaneously, density pinching to the axis. Experiments demonstrated that plasma density at the exit from the transport section is suppressed with activation of the helical field, the effect is significant and highly reproducible. The most pronounced effect is observed on the plasma periphery, where the mirror ratio is the highest. The integral suppression ratio reaches 2–2.5 in the discussed experiments. Experimental results are compared with simplified theoretical estimates. The integral suppression ratio matches the simple theoretical estimates even if the transversal diffusion is neglected.
Lymphoproliférations T associées au virus d'Epstein-Barr. (1998)

Depuis sa decouverte en 1964 dans une lignee de lymphome de Burkitt africain, le virus d'Epstein-Barr (EBV) a ete identifie dans de nombreuses autres maladies telles la mononucleose infectieuse, le carcinome du nasopharynx et la maladie de Hodgkin. Dans les proliferations lymphoides benignes ou malignes, il est classiquement associe aux lymphocytes B. Cependant, les observations montrant la presence de ce virus dans des lymphomes T non hodgkiniens et dans des leucemies T sont de plus en plus nombreuses. La transformation in vitro de lymphocytes B humains par l'EBV en lignees cellulaires lymphoblastoides B (LCL) est devenue routiniere. On sait, a present, qu'il est possible de transformer in vitro des lymphocytes T humains par l'EBV. Dans ces lignees T d'un phenotype naif, le virus exprime les genes EBNA 1 et LMP1. Cette presence est egalement retrouvee de facon majoritaire dans les maladies T associees a l'EBV. L'etude de ces cellules T transformees devrait favoriser la comprehension du role joue par l'EBV dans les lymphoproliferations T.
Online physical-layer impairment-aware routing with quality of transmission constraints in translucent optical networks (2009)

We propose a novel online physical-layer impairment-aware routing algorithm taking into account a minimum quality of transmission (QoT) constraint, which must be satisfied in all cases, even if the network load is changing, and new channels are activated. Our online constraint-based routing (CBR) algorithm considers the actual network load to get a more exact prediction of the signal quality degradation due to (multi-channel) nonlinear fiber impairments. We present results showing that the proposed online CBR algorithm is superior to shortest path routing with maximum transparent distance constraints as well as offline CBR algorithms, which are based on worst-case Q-factor penalties, in terms of blocking probability.
Self-assembly and mineralization of peptide-amphiphile nanofibers (2023)

Peptide-amphiphilic compositions capable of self-assembly into useful nanostructures.