gebhart/patrepeval huggingface dataset:
Closing the Gaps in Inertial Motion Tracking (2018)

A rich body of work has focused on motion tracking techniques using inertial sensors, namely accelerometers, gyroscopes, and magnetometers. Applications of these techniques are in indoor localization, gesture recognition, inventory tracking, vehicular motion, and many others. This paper identifies room for improvement over today's motion tracking techniques. The core observation is that conventional systems have trusted gravity more than the magnetic North to infer the 3D orientation of the object. We find that the reverse is more effective, especially when the object is in continuous fast motion. We leverage this opportunity to design MUSE, a magnetometer-centric sensor fusion algorithm for orientation tracking. Moreover, when the object's motion is somewhat restricted (e.g., human-arm motion restricted by elbow and shoulder joints), we find new methods of sensor fusion to fully leverage the restrictions. Real experiments across a wide range of uncontrolled scenarios show consistent improvement in orientation and location accuracy, without requiring any training or machine learning. We believe this is an important progress in the otherwise mature field of IMU-based motion tracking.
Characterization of a Unique Anti-DNA Hybridoma (1998)

We have previously described the isolation and in vitro binding properties of eight anti-DNA monoclonal antibodies (MAbs) from an MRL-lpr mouse. In light of recent reports that have indicated it is possible to isolate multiple MAbs from a single hybridoma, our pathogenic hybridoma, 11F8, was examined for evidence of similar phenomena. Chromosome counting suggested that 11F8 cells are unusual and might indeed be expressing multiple heavy and/or light chains. PCR, cloning, and sequencing of immunoglobulin heavy and light chains indicate that 11F8 displays expression of both gamma 2a and gamma 3 heavy chains at the DNA level. Flow cytometry and amino acid sequencing reveals that expression of multiple isotypes also occurs at the protein level but only a single heavy- and light-chain sequence is able to bind DNA. Based on these results, we conclude that 11F8 is an unusual hybridoma that secretes two distinct heavy and at least one light chain from a single cell, and may represent a trioma, a stable three-cell fusion.
Ultrafast laser inscribed waveguides for mid-infrared interferometry (2016)

International audience
Supplementary Table 1 from A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti–Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors (2023)

&lt;p&gt;Supplementary Table 1. Summary of the Most Common (&gt;10%) Treatment-Emergent Adverse Events&lt;/p&gt;
The Electromagnetism Point of View (2014)

Given that a wireless system relies on the propagation of electromagnetic waves for the transmission of information, this chapter discusses the minimum set of functions to be implemented in a transceiver by considering the theory of electromagnetism. It first focuses on free space radiation and then presents a few words about the constraints linked to electromagnetic guided propagation. This mode of conduction may be used in different parts of a transceiver, for instance between the radiating elements and the active parts of the line-up. Another set of constraints on the dimensioning of transceivers comes from the characteristics of the propagation channel. The chapter illustrates the basic concepts associated with the classical description of the propagation channel in order to introduce their related impacts on receivers.
QUANTUM HALL EFFECT IN AlAs 2D ELECTRON SYSTEMS (2002)

We report on Fabrication of two-dimensional electrons in AlAs quantum wells with mobilities up to 31 m 2 /Vs. Magnetoresistance measurements reveal fractional quantum Hall states at high-order filling factors, and up to ν = 11/3. Shubnikov-de Haas oscillations of high-density samples suggest that electrons occupy two X-point valleys. We also study properties of hysteretic resistance spikes occurring at transitions between quantum Hall ferromagnets in AlAs quantum wells, and show that the spike hysteresis depends sensitively on the number of occupied energy levels involved in the transition.
How common and frequent is heterosexual anal intercourse among South Africans? A systematic review and meta‐analysis (2017)

Reported heterosexual AI is common but variable among South Africans. Nationally and regionally representative sexual behaviour studies that use standardized recall periods and confidential interview methods, to aid comparison across studies and minimize reporting bias, are needed. Such data could be used to estimate the extent to which AI contributes to South Africa's HIV epidemic.
High-Resolution Mapping of Carbene-Based Protein Footprints (2012)

Carbene chemistry has been used recently in structural mass spectrometry as a labeling method for mapping protein surfaces. The current study presents a method for quantitating label distribution at the amino acid level and explores the nature and basis for an earlier observation of labeling bias. With the use of a method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) applied to digests of holo-calmodulin, we developed a quantitation strategy to map site-specific incorporation of carbene, generated from photolysis of ionic label precursors 2-amino-4,4-azipentanoic acid and 4,4-azipentanoic acid. The approach provides reliable incorporation data for fragments generated by electron-transfer dissociation, whereas high-energy collisional dissociation leads to energy and sequence-dependent loss of the label as a neutral. However, both can produce data suitable for mapping residues in the interaction of holo-calmodulin with M13 peptide ligand. Site-specific labeling was monitored as a function of reagent, ionic strength, and temperature, demonstrating that electrostatic interactions at the protein surface can "steer" the distribution of label precursors to sites of surface charge and favor label insertion into residues in the vicinity of the surface charge. A further preference for insertion into carboxylates was observed, based on chemical reactivity. We suggest that decoupling surface partitioning from the chemistry of insertion offers a flexible, tunable labeling strategy for structural mass spectrometry that can be applied to a broad range of protein surface compositions and promotes the design of reagents to simplify the workflow.
Benefits of multi-layer switch architectures (2003)

Multi-layer switch (MLS) architectures take advantage of recent advances in transport systems, optical switching, electrical. switching, and routing algorithms to significantly reduce the cost of next generation networks. Although each is valuable as a stand-alone technology, combined they provide a number of additional benefits that can only be achieved when fully integrated. This includes elimination of back-to-back infra-office interfaces, optical to electrical conversions at by-pass nodes, and signal regenerators along the routes. Along with the reduced equipment count comes savings in floor space, power, sparing, network management, fibre congestion, and operational costs. Advanced signalling and routing protocols are required as well to fully utilize the increase in connectivity options. Consequently, all four emerging technologies must be employed together to fully realize the promise of true optical networking and leverage the value each brings.
FLAG-induced remission in a patient with acute mast cell leukemia (MCL) exhibiting t(7;10)(q22;q26) and KIT D816H (2013)

Mast cell leukemia (MCL) is a life-threatening disease associated with high mortality and drug-resistance. Only few patients survive more than 12 months. We report on a 55-year-old female patient with acute MCL diagnosed in May 2012. The disease was characterized by a rapid increase in white blood cells and mast cells (MC) in the peripheral blood, and a rapid increase of serum tryptase levels. The KIT D816H mutation was detected in the blood and bone marrow (BM). Induction chemotherapy with high-dose ARA-C and fludarabine (FLAG) was administered. Unexpectedly, the patient entered a hematologic remission with almost complete disappearance of neoplastic MC and a decrease of serum tryptase levels to normal range after 2 cycles of FLAG. Consecutively, the patient was prepared for allogeneic stem cell transplantation. However, shortly after the third cycle of FLAG, tryptase levels increased again, immature MC appeared in the blood, and the patient died from cerebral bleeding. Together, this case shows that intensive chemotherapy regimens, like FLAG, may induce remission in acute MCL. However, treatment responses are short-lived and the overall outcome remains dismal in these patients. We propose to separate this acute type of MCL from more subacute or chronic variants of MCL.
Reversible gel formation induced by ion complexation. 2. Phase diagrams (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReversible gel formation induced by ion complexation. 2. Phase diagramsE. Pezron, L. Leibler, A. Ricard, and R. AudebertCite this: Macromolecules 1988, 21, 4, 1126–1131Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/ma00182a046https://doi.org/10.1021/ma00182a046research-articleACS PublicationsRequest reuse permissionsArticle Views518Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Design of Gelled Fluid for Debris Removal in Subsea Pipeline (2012)

Abstract Transportation of hydrocarbon through a pipeline may be hindered as a result of deposition of debris. The presence of debris within the pipeline leads to reduction in the effective flow area, thus reducing the efficiency of the transportation system. Some of the factors leading to formation of the debris are changes in temperature and/or pressure of the transported fluid and chemical reactions which occur therein. Pipeline maintenance pigging is routinely performed to extend the operational life of pipelines. Recently, a combination of mechanical and chemical remedial measures has shown beneficial results in pipeline cleaning. Mechanical brush pigs loosen the debris adhering to the walls, while chemical techniques, such as the use of gelled fluids, enhance the carrying capacity and help to transport the loosened debris out of the pipeline. This paper presents the results of tests conducted to design a fast-breaking gelled fluid for a debris-removal operation in a long, large diameter subsea pipeline in the Asia Pacific region. In addition to exhibiting good stability and debris-carrying capacity under the laboratory test and field conditions, the gel had to be compatible and demonstrate stability when mixed with other additives in the transported hydrocarbon. A highly viscous, aqueous-based linear polysaccharide gel was designed to satisfy these requirements. A key environmental and operational consideration was the easy and fast disposal of the gel after completion of the cleaning operation. With oxidizing breaker, gels prepared in potable water resulted in viscosity of &amp;lt; 10 cp within two days, which was significantly shorter than when seawater-based gels were similarly treated. Preliminary field results indicate that the combined mechanical and gel system removed significant amount of debris. Data from future trials will help evaluate the feasibility of such technique for effective cleaning of the pipeline.
Proteolysis-inducing factor differentially influences transcriptional regulation in endothelial subtypes (2002)

Proteolysis-inducing factor (PIF) is a novel sulfated glycoprotein initially identified as a protein capable of triggering muscle proteolysis during the process of cancer cachexia. Only skeletal muscle and liver exhibit substantial binding of PIF in adult tissue. Here, we demonstrate that PIF induces transcriptional regulation in both the liver endothelial cell line SK-HEP-1 and in human umbilical vein endothelial cells (HUVECs) but not in pulmonary artery endothelial cells. PIF differentially induces activation of nuclear factor-kappaB, resulting in the induction of proinflammatory cytokines [interleukin (IL)-8 and IL-6] and increased expression of the cell surface proteins intercellular adhesion molecule-1 and vascular cell adhesion molecule in SK-HEP-1 and HUVECs only. In addition, PIF induces the shedding of syndecans from the cell surface. Syndecans are involved in wound repair, metastasis of cancers, and embryonic development. These results suggest that PIF may play additional roles in the proinflammatory response observed in cancer cachexia but may also have a role without the cachectic process.
Activation of Secretagogue Independent Gastric Acid Secretion via Endothelial Nitric Oxide Synthase Stimulation in Rats (2017)

We conclude that L-arginine is a novel secretagogue, which can mediate gastric acid secretion. Furthermore, the intake of L-arginine causes direct activation of the H+, K+ ATPase and increased proton extrusion from parietal cells resulting in the increased risk for acid-related diseases. The NO/sGC/cGMP pathway has never been described as a possible intracellular mechanism for H+, K+ ATPase activation before and presents a completely new scientific finding. Moreover, our studies demonstrate a novel role for L-NAME to effectively eliminate NOS induced acid secretion and thereby reducing the risk for L-arginine inducible ulcer disease.
A PRESS statistic for two-block partial least squares regression (2010)

Predictive modelling of multivariate data where both the covariates and responses are high-dimensional is becoming an increasingly popular task in many data mining applications. Partial Least Squares (PLS) regression often turns out to be a useful model in these situations since it performs dimensionality reduction by assuming the existence of a small number of latent factors that may explain the linear dependence between input and output. In practice, the number of latent factors to be retained, which controls the complexity of the model and its predictive ability, has to be carefully selected. Typically this is done by cross validating a performance measure, such as the predictive error. Although cross validation works well in many practical settings, it can be computationally expensive. Various extensions to PLS have also been proposed for regularising the PLS solution and performing simultaneous dimensionality reduction and variable selection, but these come at the expense of additional complexity parameters that also need to be tuned by cross-validation. In this paper we derive a computationally efficient alternative to leave-one-out cross validation (LOOCV), a predicted sum of squares (PRESS) statistic for two-block PLS. We show that the PRESS is nearly identical to LOOCV but has the computational expense of only a single PLS model fit. Examples of the PRESS for selecting the number of latent factors and regularisation parameters are provided.
Scan Time Reduction for Three-Directional Phase Contrast Sequences: A Signal Processing Approach (2011)

The traditional phase contrast reconstruction for three-directional flow encoding extracts a single velocity point from four acquisitions, yielding a final temporal resolution equal to four times the duration of a single encoding step. The temporal resolution can be increased by a “sliding window” reconstruction, but significant distortions of the frequency content of the signal can still be present. In this work, we present a postprocessing method based on inverse signal filtering that can partially compensate for the distortion, thus effectively increasing the available bandwidth by a factor of two with respect to the conventional reconstruction, and therefore enabling an analogous decrease of the total acquisition time.
C-band side-entry Ge quantum-well electroabsorption modulator on SOI operating at 1 V swing (2007)

An electroabsorption modulator using a side-entry architecture achieved a contrast ratio exceeding 3 dB over a 3.5 nm range in the C-band, using a voltage swing of 1 V and operating at 100°C. Modulation was due to the quantum-confined Stark effect from ten Ge/SiGe quantum wells epitaxially grown on silicon-on-insulator (SOI) wafers. The device exploits an asymmetric Fabry-Perot resonator formed between the totally internally reflecting air-SiGe interface and a frustrated total internal reflection from the buried oxide layer of the SOI substrate.
Realization of Quantum Walks with Negligible Decoherence in Waveguide Lattices (2008)

Quantum random walks are the quantum counterpart of classical random walks, and were recently studied in the context of quantum computation. Physical implementations of quantum walks have only been made in very small scale systems severely limited by decoherence. Here we show that the propagation of photons in waveguide lattices, which have been studied extensively in recent years, are essentially an implementation of quantum walks. Since waveguide lattices are easily constructed at large scales and display negligible decoherence, they can serve as an ideal and versatile experimental playground for the study of quantum walks and quantum algorithms. We experimentally observe quantum walks in large systems ( approximately 100 sites) and confirm quantum walks effects which were studied theoretically, including ballistic propagation, disorder, and boundary related effects.
Further Studies on Conformationally Constrained Tricyclic Tropane Analogues and Their Uptake Inhibition at Monoamine Transporter Sites:  Synthesis of (Z)-9-(Substituted arylmethylene)-7-azatricyclo[4.3.1.03,7]decanes as a Novel Class of Serotonin Transporter Inhibitors (2002)

A novel series of conformationally constrained tricyclic tropane analogues, (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes, were prepared, and their abilities to inhibit high-affinity uptake of dopamine (DA), serotonin (5-HT), and norepinephrine (NE) into rat brain nerve endings (synaptosomes) were evaluated. First, a systematic screening of a variety of different substituents on the phenyl ring indicated that the substitution pattern plays an important role in the monoamine transporter activity. Most compounds in this series possessed a very low activity at the DA transporter (DAT) but a good to excellent affinity for the 5-HT transporter (SERT). In the case of para-substituted phenyl analogues, the electronic character of the substituent did not affect uptake inhibition as dramatically as observed in some benztropine analogues. Among these compounds, the 4-bromophenyl and 4-isopropylphenyl analogues 8d and 8j exhibited the highest potency at the SERT with a K(i) value of 10 nM. In the 3,4-disubstituted phenyl series, even more potent and highly selective compounds were discovered. Compound 8o has a K(i) value of 2.3 nM for uptake inhibition at the SERT, a DAT/SERT uptake ratio of 2360, and a NET/SERT uptake ratio of 200. Compound 8p exhibited a K(i) value of 1.8 nM for uptake inhibition at the SERT, a DAT/SERT uptake ratio of 1740, and a NET/SERT uptake ratio of 151. These compounds are 3-4-fold more potent than the antidepressant medication fluoxetine, and the selectivities for SERT over DAT and NET are also better than those of fluoxetine. Second, a variety of functional modifications on the ester moiety were investigated. Substitution by other esters or amides as well as alkenes did not increase potency, while most of the acetates or benzoates (16-21, 23, and 24) and the ketone 28 exhibited significantly improved activity. A good hydrogen-bonding ability of the substituent is believed to be required for high activity. The most potent and selective ligand is compound 23, which displayed a K(i) value of 0.06 nM and has essentially no activity at the DAT or NET. The present results have important implications for drug addiction as well as a number of psychiatric diseases.
The effect of subsurface doping on gate oxide charging damage (1998)

The effect of wells and substrate type on gate oxide charging damage during plasma processing, and more specifically plasma immersion ion implantation, is modeled. The simulation combines the equations governing the plasma currents and integrated circuit device models to determine the gate oxide stressing voltage during implantation. Depending on the substrate type and the surface potential (V/sub s/), a depletion region may exist, reducing the gate oxide voltage, and hence the gate oxide damage. In addition, well structures, by the nature of their capacitance, modulate V/sub s/, altering the oxide stressing voltage. For most PIII implant conditions, gate oxides with p-type channel doping will be damaged more than those oxides with n-type channel doping. Experimental results confirm the substrate and well effects on plasma charging damage.
Imaging of cerebral activation at 1.5 T: optimizing a technique for conventional hardware. (1994)

Good results can be obtained at functional MR imaging with standard 1.5-T hardware. Markedly improved results can be obtained by optimizing several key variables, namely, section thickness, TE, and FOV.
Geometry of Optimization and Implicit Regularization in Deep Learning (2017)

We argue that the optimization plays a crucial role in generalization of deep learning models through implicit regularization. We do this by demonstrating that generalization ability is not controlled by network size but rather by some other implicit control. We then demonstrate how changing the empirical optimization procedure can improve generalization, even if actual optimization quality is not affected. We do so by studying the geometry of the parameter space of deep networks, and devising an optimization algorithm attuned to this geometry.
Oxycombustion in pulverized coal-fired boiler: a promising technology for CO 2 capture (2004)

A promising technology that enables CO2 capture from pulverized coal-fired power plants is described. The technology involves the replacement of the combustion air by pure oxygen diluted with recirculated flue gases, and is referred to as oxycombustion process. The resulting CO2/O2 oxidizer provides a high flexibility for temperature and flowrate control inside the boiler. Therefore, both retrofit and new boiler applications are envisioned. The economics of the oxycombustion process have been assessed and compared to that of the same capacity air-blown coal-fired boiler equipped with amine (MEA) scrubber for carbon capture. Both capture technologies result in increased cost of electricity. However, this increase is expected to be at least 30 % lower using O2/CO2 technology than using MEA system. The oxycombustion process leads to approximately $20/ton CO2 avoided, while MEA process requires more than $40/ton CO2. The main results of experimental tests performed on a pilot-scale boiler are also presented. Low-sulfur sub-bituminous coal was burned and the reported results highlight the characteristics of oxygen-fired mode versus air-fired mode. 70 % NOx emission reduction has been observed, and emission level as low as 0.08 lb / 106 Btu has been measured. The flue gas flow rate has been