gebhart/patrepeval huggingface dataset:
Benefits of Positioning-Aided Communication Technology in High-Frequency Industrial IoT (2018)

The future of industrial applications is shaped by intelligent moving IoT devices, such as flying drones, advanced factory robots, and connected vehicles, which may operate (semi-)autonomously. In these challenging scenarios, dynamic radio connectivity at high frequencies -- augmented with timely positioning-related information -- becomes instrumental to improve communication performance and facilitate efficient computation offloading. Our work reviews the main research challenges and reveals open implementation gaps in Industrial IoT (IIoT) applications that rely on location awareness and multi-connectivity in super high and extremely high frequency bands. It further conducts a rigorous numerical investigation to confirm the potential of precise device localization in the emerging IIoT systems. We focus on positioning-aided benefits made available to multi-connectivity IIoT device operation at 28 GHz, which notably improve data transfer rates, communication latency, and extent of control overhead.
<title>Time reduction of MCM-D prototype realization by process control and modeling</title> (1996)

The evolution of advanced packaging techniques like multi chip modules makes the realization of prototypes necessary. This can be a long and costly operation. Therefore we developed methods permitting time gains to be made in two of the steps of this operation. To avoid the use of physical masks we have experimented a laser beam set for direct writing of metal and insulating layers in microcircuits. To shorten preliminary tests, we propose a theoretical model of the interaction between the laser beam and the photoresist. It permits us to predict the line widths etched in the photoresist and thus avoids the need of long calibration processes. Electrical test lines of various widths have been used as a validation tool. The precision obtained is better than 5%. Polyimides (PI) meet most of the requirements for dielectric materials. As the curing process is crucial for the properties of the final PI film, thermal treatment was the subject of optimization leading however to process time up to more than 4 hours. We developed an interferometric control system in combination with a hot plate in order to provide an automated and optimized curing process. Total curing time is reduced to 1- 2 hours. Characterization and FTIR measurements were done for conventional and interferometrically controlled curing samples before and after aging in wet atmosphere: controlled samples are more crystalline, show comparable electrical and reliability properties, and seem less stressed.
Quality Metrics in High-Dimensional Data Visualization: An Overview and Systematization (2011)

In this paper, we present a systematization of techniques that use quality metrics to help in the visual exploration of meaningful patterns in high-dimensional data. In a number of recent papers, different quality metrics are proposed to automate the demanding search through large spaces of alternative visualizations (e.g., alternative projections or ordering), allowing the user to concentrate on the most promising visualizations suggested by the quality metrics. Over the last decade, this approach has witnessed a remarkable development but few reflections exist on how these methods are related to each other and how the approach can be developed further. For this purpose, we provide an overview of approaches that use quality metrics in high-dimensional data visualization and propose a systematization based on a thorough literature review. We carefully analyze the papers and derive a set of factors for discriminating the quality metrics, visualization techniques, and the process itself. The process is described through a reworked version of the well-known information visualization pipeline. We demonstrate the usefulness of our model by applying it to several existing approaches that use quality metrics, and we provide reflections on implications of our model for future research.
Synthesis of Glycopeptides Containing Carbohydrate and Peptide Recognition Motifs (2000)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Glycopeptides Containing Carbohydrate and Peptide Recognition MotifsHolger Herzner, Tanja Reipen, Michael Schultz, and Horst KunzView Author Information Johannes Gutenberg-Universität, Institut für Organische Chemie, Duesbergweg 10-14, 55128 Mainz, Germany Cite this: Chem. Rev. 2000, 100, 12, 4495–4538Publication Date (Web):November 3, 2000Publication History Received17 March 2000Published online3 November 2000Published inissue 1 December 2000https://doi.org/10.1021/cr990308cCopyright © 2000 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views3769Altmetric-Citations258LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (868 KB) Get e-AlertsSUBJECTS:Monomers,Organic compounds,Organic polymers,Peptides and proteins,Solid phase synthesis Get e-Alerts
Compression techniques for improving underwater acoustic transmission of images and data (2002)

Efficient use of the bandwidth-limited acoustic communications link requires that considerable attention be given to both removing redundancy in data and minimizing superfluous resolution. In this paper we present techniques for compression of laser line scan and camera images, as well as format-specific data compression for quick-look sonar mapping data. For image compression JPEG and a wavelet-based technique (EPIC) are examined. JPEG is found to be less efficient than the wavelet transform but has the advantage that it is robust with respect to lost data packets. The wavelet-based transform is more efficient at high compression rates though below a certain rate both offer similar performance. The specific context for this work is the autonomous minehunting and mapping technology (AMMT) demonstration which utilizes the DARPA large diameter underwater vehicle. The ultimate goal of the project is identification and imaging of mine-like objects. The algorithms presented here were implemented in real-time and operated in the field for this program. Details of specific issues encountered during development of the system are also described.
Clinical Research Skills Development Program in Cell-Based Regenerative Medicine (2014)

Cell-based therapy aimed at restoring organ function is one of the most exciting and promising areas of medical research. However, a novel intervention like cell-based therapy requires physician education and training. An increasing number of physicians untrained in regenerative medicine are using cell-based therapy to treat patients for a wide variety of chronic illnesses. The current lack of training for physicians in this area combined with the sharply increasing practice of regenerative medicine is concerning for a number of reasons, namely potential harm to patients and avoidable conflicts between governmental regulatory agencies and physicians. Academic medical fellowship training programs are needed that specifically prepare physicians for treating patients with cell-based therapies for various organ systems and chronic diseases. The National Heart, Lung, and Blood Institute established the Cardiovascular Cell Therapy Network to design and conduct clinical trials that advance the field of cell-based therapy for patients with cardiovascular disease. As part of the network, a two-year Clinical Research Skills Development Program was supported at two centers with the goal of training early career investigators in cell-based clinical and translational research. In this review, we describe the implementation of this training program at our institution with the purpose of promoting the further development of academic fellowship programs in cell-based regenerative medicine.
The structure of 5-amino-4-methyl-1-isoquinolinecarbaldehyde thiosemicarbazone hydrochloride, C12H14N5S+.Cl− (1984)

(1), b= 13.906 (1), c= 12.040 (2) A, fl= 92.95 (1) , V= 1385.0 (5) ,/k 3, Z = 4, D m = 1.42, D x = 1.418 Mg m -3, 2(Cu K~t) = 1.54178 A,, g = 3.8134 mm -~, F(000) = 616, R =0.061 for 628 unique significant reflections measured at 298 K. The structure was compared with that of other active/inactive thiosemicarbazone derivatives, in the search for a structure-activity relationship. It was also compared with the structure of a related metal complex.
Somatostatin analogues increase AIP expression in somatotropinomas, irrespective of Gsp mutations (2013)

Germline aryl hydrocarbon receptor interacting protein (AIP) gene mutations confer a predisposition to pituitary adenoma (PA), predominantly GH-secreting (GH-PA). As recent data suggest a role for AIP in the pathogenesis of sporadic GH-PA and their response to somatostatin analogues (SSA), the expression of AIP and its partner, aryl hydrocarbon receptor (AHR), was determined by semiquantitative immunohistochemistry scoring in 62 sporadic GH-PA (37 treated with SSA preoperatively). The influence of Gsp status was studied in a subset of tumours (n=39, 14 Gsp(+)) and six GH-PA were available for primary cultures. AIP and AHR were detected in most cases, with a positive correlation between AIP and cytoplasmic AHR (P=0.012). Low AIP expression was significantly more frequent in untreated vs SSA-treated tumours (44.0 vs 20.5%, P=0.016). AHR expression or localisation did not differ between the two groups. Similarly, in vitro octreotide induced a median twofold increase in AIP expression (range 1.2-13.9, P=0.027) in GH-PA. In SSA-treated tumours, the AIP score was significantly higher in the presence of preoperative IGF1 decrease or tumour shrinkage (P=0.008 and P=0.014 respectively). In untreated tumours, low AIP expression was significantly associated with invasiveness (P=0.028) and suprasellar extension (P=0.019). The only effect of Gsp status was a significantly lower nuclear AHR score in Gsp(+) vs Gsp(-) tumours (P=0.025), irrespective of SSA. In conclusion, AIP is involved in the aggressiveness of sporadic GH-PA, regardless of Gsp status, and AIP up-regulation in SSA-treated tumours is associated with a better preoperative response, with no clear role for AHR.
Scanning Tunneling Optical Microscopy (STOM) Using A Stylus Sensor Application To Topography Analysis Of Guiding Surfaces (1989)

For overpassing the classical limit of resolution in optical microscopy, it is necessary to detect the diffracted light from small objects in the near field and not in the far field as in classical microscopy. A particular case is the detection of the evanescent field lying on the surface of a guiding structure. These surface waves interact with the object details and then can be used for determining the topography of the object. The chief problem is the detection because the light beam is confined on the object surface. A solution consists of frustrating the evanescent field by means of a dielectric probe. The conversion of the in-homogeneous waves into homogeneous ones is fundamentally similar to the electronic tunneling effect. Subwavelength resolution can be obtained by placing a suitable optical stylus connected to an optical fibre near the surface. A xyz piezo-electric micropositioning system allows then to scan the object surface under test. A microscope exploiting this principle has been built. Preliminary experimental results are presented and discussed.
An active learning approach to the physics of medical imaging (2007)

This paper describes an experimentally oriented medical imaging course where the students record, process and analyse 3D data of an unknown piece of formalin fixed porcine tissue hidden in agar in order to estimate the tissue types present in a selected 2D slice. The recorded planar X-ray, CT, MRI, ultrasound and SPECT images show the tissue in very different ways. The students can only estimate the tissue type by studying the physical principles of the imaging modalities. The true answer is later revealed by anatomical photographs obtained from physical slicing. The paper describes the phantoms and methods used in the course. Sample images recorded with the different imaging modalities are provided. Challenges faced by the students are outlined. Results of the course show high increase in competencies as judged from graded reports, low course drop-out rate, high pass-rate at the exam, high student participation and large student satisfaction.
K-1502 Laser Diagnostics of the Flame Base Structure of Turbulent Lifted Jet Flames (2001)

Flame base structures of lifted diffusion flames have been investigated experimentally by using a simultaneous Rayleigh and Raman scattering method. The rations of signal to noise are estimated approximately 50 for the Rayleigh scattering method and 15 for the Raman scattering one, respectively. Experiments have been conducted in the configuration of a coaxial burner consisting of an inner tube of 3.2 ID and an outer tube of 56 ID. As a result, it is found that flames seem to limit the turbulent mixing and moreover at the flame base of lifted flames the nitrogen concentration increases near the center region of the jet, due to the turbulent mixing in the unburned region at the flame base, although decreasing at the flame region.
Antiviral and Virucidal Activities of Natural Products (2009)

Virus infection is one of the major threats to human health and can be avoided by minimizing exposure to infectious viruses. Viral clearance of pharmaceutical products and sanitization of skin and mucosal surfaces would reduce such exposures. Even with such care, virus infection does occur, requiring effective treatments by antiviral or virucidal agents. Natural products, in particular ingredients of foods and drinks we normally consume or metabolites present in human body at low concentrations, would have advantage over synthetic drugs as antiviral agents for safety concerns. For this reason, we have been studying natural products for their effects on virus inactivation and growth. Such natural products, which we have been focusing, include gallate derivatives, caffeine present in coffee, caffeic acid present in coffee and various fruits, ascorbic and dehydroascorbic acids and a cell metabolite, arginine. Here we will review our work on antiviral and virucidal activities of these compounds and the mechanism of their antiviral and virucidal effects.
ULTRA HIGH APERTURE ANGLE OBJECTIVES AND NEW EMBEDDING MEDIUM BOOST 4PI MICROSCOPY APPLICATIONS (2007)

4Pi microscopy [1] relies on the constructive coherent addition of the wavefront caps of two opposing high aperture angle lenses. The intensity point-spread-function (PSF) consists of a predominant, narrow main diffraction maximum and higher order axial side maxima (lobes) above and below the focal plane. The main maximum features a resolution that is enhanced by a factor 3-7 compared to a compared to the resolution obtained in conventional or confocal microscopy. In order to benefit of the higher resolution of it is necessary to end up with sidelobe-free images. The key element of super-resolving 4Pi microscopy is the aperture angle. The recently available oil-immersion objectives with an angle of α = 74° (1.46 Oil, Leica Microsystems, Germany) allow to further strengthen the 4Pi concept by increasing the solid aperture angle of the system. We show that these objectives, together with a new sample embedding, result in virtually sidelobe-free images in the 2photon type C mode. The sidelobes of ~10 % are achieved (Fig. 1) and therefore deconvolution is obsolete in most cases. Furthermore, the large angle enables 1-photon 4Pi microscopy of type C as well as of type A (Fig. 2). Both setups do not need a modelocked 2-photon laser, allowing for an inexpensive and simple setup at a higher quantum yield. In the case of 1-photon type A the fluorescence light is collected incoherently, rendering even path length and dispersion adjustments obsolete. This enables the most simple 4Pi setup; it can readily be implemented in commercially available 4Pi scanners to benefit from the enhanced resolution (108 nm at λexc=488 nm). On the other hand 1-photon type C offers a higher resolution (86 nm at λexc=488 nm) and lower sidelobes, which makes this setup more robust towards residual aberrations. However, to make use of these options proper sample optics is important. We therefore use the water-miscible TDE (2,2’Thiodiethanol) [2] as embedding medium. It allows us to match exactly the refractive index to the glass-oil system (n=1.518) to omit spherical aberration.
Searching for the Casimir Energy (2020)

In this article, we present a nano-electromechanical system (NEMS) designed to detect changes in the Casimir Energy. The Casimir effect is a result of the appearance of quantum fluctuations in the electromagnetic vacuum. Previous experiments have used nano- or micro- scale parallel plate capacitors to detect the Casimir force by measuring the small attractive force these fluctuations exert between the two surfaces. In this new set of experiments, we aim to directly detect shifts in the Casimir $\textit{energy}$ in the vacuum due to the presence of metallic parallel plates, one of which is a superconductor. A change in the Casimir energy of this configuration is predicted to shift the superconducting transition temperature (T$_\textrm{c}$) because of an interaction between it and the superconducting condensation energy. The experiment we discuss consists of taking a superconducting film, carefully measuring its transition temperature, bringing a conducting plate close to the film, creating a Casimir cavity, and then measuring the transition temperature again. The expected shifts will be small, comparable to the normal shifts one sees in cycling superconducting films to cryogenic temperatures and so using a NEMS resonator and doing this in situ is the only practical way to obtain accurate, reproducible data. Using a thin Pb film and opposing Au surface, we observe no shift in T$_\textrm{c}$ greater than 12 $μ$K down to a minimum spacing of approximately 70 nm.
Confocal endomicroscopy: new optical systems for diagnoses (2015)

International audience
Heart rate score, a measure related to chronotropic incompetence in pacemaker patients (2021)

HrSc ≥70% correlates with treadmill measures of CI and clinical sick sinus syndrome. HrSc ≥70% is a measure of CI in PM subjects that is inexpensive, repeatable, and quantitative.
EXPERIMENTAL RESULTS OF GUIDED WAVE TRAVEL TIME TOMOGRAPHY (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Arno Volker, Joost Bloom; EXPERIMENTAL RESULTS OF GUIDED WAVE TRAVEL TIME TOMOGRAPHY. AIP Conference Proceedings 23 June 2011; 1335 (1): 215–222. https://doi.org/10.1063/1.3591859 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Dietary protein restriction rapidly reduces transforming growth factor beta 1 expression in experimental glomerulonephritis. (1991)

Dietary protein restriction has been shown to slow the rate of loss of kidney function in humans with progressive glomerulosclerosis due to glomerulonephritis or diabetes mellitus. A central feature of glomerulosclerosis is the pathological accumulation of extracellular matrix within the diseased glomeruli. Transforming growth factor beta 1 (TGF-beta 1) is known to have widespread regulatory effects on extracellular matrix and has been implicated as a major cause of increased extracellular matrix synthesis and buildup of pathological matrix within glomeruli in experimental glomerulonephritis. In the present study, it is shown that administration of a low protein diet to rats rapidly reduces the elevated expression of TGF-beta 1 mRNA and TGF-beta 1 protein that is known to occur within glomeruli after induction of glomerulonephritis. Compared to a normal protein diet, glomerulonephritic rats receiving the low protein diet did not develop an increase in glomerular extracellular matrix and showed significantly less proteinuria. Glomeruli isolated from glomerulonephritic rats fed the normal protein diet showed a marked increase in proteoglycan synthesis on day 7 of disease and were demonstrated to be secreting increased amounts of TGF-beta 1 into the medium, whereas glomeruli at the same point in time isolated from rats on a low protein diet showed no increase in proteoglycan production or TGF-beta 1 secretion. These results suggest that a mechanism of the rapid therapeutic effect of a low protein diet on experimental glomerulonephritis is through suppression of TGF-beta 1 expression and prevention of the induction of extracellular matrix synthesis within the injured glomeruli.
Robotic chromatography: development and evaluation of automated instrumentation for assay of glycohemoglobin (1993)

The measurement of glycohemoglobin (GHb) by boronate affinity chromatography is useful in monitoring long-term glucose control in diabetic subjects. The inherent disadvantage of this method is the hands-on time required because the hemoglobin fractions are separated on individual disposable columns. To overcome this disadvantage, we have programmed a Hamilton Microlab 2200 automated pipetting cartesian robot to complete the procedure, from the aspiration of blood from the sample-collection tube to the transfer of the separated hemoglobin fractions to a microtiter plate for absorbance measurement. This automated robotic system can analyze 96 specimens, including patients' samples and control material, in approximately 3 h. The precision (CV) of the method ranged from 1.6% to 3.5% within-run and from 2.7% to 3.5% day-to-day. The results correlated with those obtained with the Accuflex semiautomated robot, which used the identical disposable column, and those obtained with a Primus high-performance liquid chromatograph, which used a regenerated microparticle column. Automation of the GHb procedure allowed improved throughput, reduced labor cost, improved precision, and offered greater laboratory safety.
Structure-activity relationship studies of arylthiazolidine amides as selective cytotoxic agents for melanoma. (2007)

The lead structure represents a novel class of compounds that can be further optimized for potential drug to treat advanced melanoma.