gebhart/patrepeval huggingface dataset:
A phase Ib study of vosaroxin, an anticancer quinolone derivative, in patients with relapsed or refractory acute leukemia (2011)

This study of vosaroxin evaluated dose-limiting toxicity (DLT), maximum-tolerated dose (MTD), pharmacokinetics (PK), clinical activity and pharmacodynamics in relapsed/refractory leukemia. Dosing was weekly (days 1, 8 and 15) or twice weekly (days 1, 4, 8 and 11). Seventy-three treated patients had a median age of 65 years, 85% had acute myeloid leukemia and 78% had refractory disease. Weekly schedule: 42 patients received 18-90 mg/m(2); MTD was 72 mg/m(2). Twice-weekly schedule: 31 patients received 9-50 mg/m(2); MTD was 40 mg/m(2). DLT was stomatitis; primary non-hematologic toxicity was reversible gastrointestinal symptoms and febrile neutropenia. Thirty-day all-cause mortality was 11%. Five patients had complete or incomplete remissions; median duration was 3.1 months. A morphologic leukemia-free state (bone marrow blast reduction to <5%) occurred in 11 additional patients. Antileukemic activity was associated with total dose or weekly time above 1 μmol/l plasma vosaroxin concentration (P<0.05). Vosaroxin exposure was dose proportional over 9-90 mg/m(2). The average terminal half-life was ~25 h and clearance was non-renal. No induction or inhibition of vosaroxin metabolism was evident. Vosaroxin-induced DNA damage was detected as increased intracellular γH2AX. Vosaroxin had an acceptable safety profile, linear PK and encouraging clinical activity in relapsed/refractory leukemia.
Progress of BazookaSPECT (2009)

Recent progress on a high-resolution, photon-counting gamma-ray and x-ray imager called BazookaSPECT is presented. BazookaSPECT is an example of a new class of scintillation detectors based on integrating detectors such as CCD(charge-coupled device) or CMOS(complementary metal-oxide semiconductor) sensors. BazookaSPECT is unique in that it makes use of a scintillator in close proximity to a microchannel plate-based image intensifier for up-front optical amplification of scintillation light. We discuss progress made in bringing about compact BazookaSPECT modules and in real-time processing of event data using graphics processing units (GPUs). These advances are being implemented in the design of a high-resolution rodent brain imager called FastSPECT III. A key benefit of up-front optical gain is that any CCD/CMOS sensor can now be utilized for photon counting. We discuss the benefits and feasibility of using CMOS sensors as photon-counting detectors for digital radiography, with application in mammography and computed tomography (CT). We present as an appendix a formal method for comparing various photon-counting integrating detectors using objective statistical criteria.
Cage and Window Effects in the Adsorption of n-Alkanes on Chabazite and SAPO-34 (2008)

The adsorption of C1−C14 n-alkanes on SAPO-34 and Na-CHA zeolites was studied at low surface coverage using the pulse chromatographic method. On both isostructural materials, containing cages interconnected via small windows, the Henry adsorption constant K′ varies in a nonmonotonous way with carbon number. K′ increases more or less exponentially with carbon number from methane to n-hexane. On Na-CHA, K′ decreases from n-hexane, reaches a minimum at n-octane, and then increases again. On SAPO-34, a minimum is attained at n-decane. From this point on, K′ increases till the longest alkane studied, i.e., n-tetradecane. On SAPO-34, the increase in zero coverage adsorption enthalpy per additional methylene group in the alkane chain becomes smaller for carbon numbers between 5 and 11. A local minimum in adsorption enthalpy occurs at n-undecane. A compensation plot between adsorption entropy and enthalpy shows a pronounced discontinuity at n-undecane for SAPO-34. The present observations provide additional proof for the existence of “window effects”. Given their molecular length, C1−C6 alkanes adsorb in a relatively unhindered way in the SAPO-34 cages. C7−C10 alkanes adopt a coiled configuration inside the cage, which strongly affects their adsorption enthalpy and entropy. From n-undecane onward, the alkanes are no longer fitting within the cage and protrude the small windows connecting the cages. The presence of cations on Na-CHA results in stronger energetic interactions compared to SAPO-34, which shifts the window protrusion to lower chain lengths.
Green-Suppressed Quasi-Phase-Matched Optical Parametric Oscillation (2013)

Parasitic green light has been a trigger of the damage in 1um-pumped OPO through GReen-Induced InfraRed Absorption (GRIIRA). A phase-reversed-cluster QPM device suppresses unwanted green light while maintaining OPO performance.
Uplink power control method for LTE femtocells based on resource usage aggregation (2012)

In LTE, uplink (UL) transmit power control is important to mitigate the UL aggregate interference from all femtocells to the macrocell, which is increased as the number of femtocells is increased. We propose an UL power control method for LTE femtocells adaptively setting target received power by using the aggregation of the resource usage of femtocells. With this method, when the aggregate resource usage is small, the UL throughput of femtocells is improved by increasing the UL transmit power. When the aggregate resource usage is large, the UL throughput of macrocells is maintained by decreasing the UL transmit power. With LTE system level simulations, it is shown that while in the full buffer traffic condition the decline in the UL throughput of macrocells due to introducing femtocells was suppressed, in the FTP traffic condition the UL throughput of femtocells was improved by 24% at the largest in comparison with the method using the number of active HeNBs.
Using Microfluidics for Metabolic Monitoring of Single Embryo Cultures (2008)

In recent years, microfluidics has demonstrated novel methods of culturing and studying cells. Within welldefined volumes comparable to the sample of interest, media, nutrients or toxins may be precisely targeted to individual cells via diffusion or advection, enabled by integrated valves and pumps. Tools, which both enable a repeatable and systematic means of single embryo culture, as well as provide information on metabolic activity of individual embryos, would be of significant utility to the embryologist. To address the need of controlled culture environments and improve embryo health and subsequent positive implantation rates, we have developed programmable microfluidic devices for quantifying metabolite levels in the culture media. Our microfluidic platform provides a high throughput, accurate and repeatable means to non-invasively assess embryo viability, which should be of significant utility to the clinical embryologist.
Induction of experimental autoimmune encephalomyelitis by native myelin basic protein‐activated T lymphocyte lines (1992)

Self antigens bind to MHC class II molecules in vivo. The capacity of class II molecules to bind native self antigen, namely antigen that has not been processed through an endososomal pathway, could increase susceptibility to autoimmune diseases if recognized by autoreactive T lymphocytes. To confirm this prediction we designed experiments to show that: (a) native myelin basic protein (BP) activates encephalitogenic T lymphocyte lines, and (b) these activated lines cause experimental autoimmune encephalomyelitis (EAE) in naive rats. We show that two encephalitogenic T lymphocytes lines, LEW and BN, are activated by native BP in the presence of paraformaldehyde pre-fixed antigen-presenting cells (APC). The degree of activation, as measured by T lymphocyte proliferation, was equal to that obtained in response to BP processed by APC prior to paraformaldehyde fixing. The response to native BP was confirmed by demonstrating insensitivity to the presence of the lysosomotropic agent chloroquine or protease inhibitors. Activation of T lymphocytes by BP required the presence of syngeneic APC. The activated T lymphocyte lines were injected into naive recipient rats that developed EAE within 5 days. Both disease incidence and severity were equal to that observed in rats that were treated with T lymphocytes activated by processed BP. Hence, at least in EAE, the risk of an autoimmune event could be precipitated by a complex of native antigen and class II molecules on cells that do not possess an endososomal pathway for antigen processing and presentation.
Advantages of Permanent Integrity Monitoring using Guided Wave Tomography (2010)

Abstract Corrosion and erosion are two major degradation mechanisms of piping systems and pipelines that both lead to wall thickness loss. To ensure sufficient integrity levels of these assets NDE is currently conducted at time based intervals often associated with shut downs. However, both economical and social requirements are pushing the industry to higher levels of availability, reliability and safety of installations at minimum costs. Using permanent sensors that continuously monitor the wall thickness of assets over large areas allows improvement of the availability of installations at lower inspection costs. Because when inline data is continuously available the maintenance can be planned (just) in time at the most optimal moment. Therefore, the permanent sensors will save inspection costs and minimize unplanned maintenance. This can not be achieved with the current method of periodic inspections and local measurements even when this is done risk based, because some corrosion processes behave unpredictable. This paper demonstrates a system that monitors the wall thickness of pipe lines over large areas in an economical attractive way using a limited number of low-power ultrasonic transducers. By applying tomographic inversion to the travel time of guided wave modes along different paths, a wall thickness map with 100% coverage can be obtained. Experimental results on a 10" steel pipe with a wall thickness of 8 mm show that this system is able to detect and size defects with a depth of 10% and diameter of 15 cm. The area covered in this case was the complete wall of a pipe with a length of 4 m. This paper further explains the performance and it will give an outlook of the possible applications and possibilities to integrate other functionality like crack monitoring with the same system. In this paper there will be a focus on applying this concept in new build installations because of the low additional costs involved when applying the sensors while manufacturing the assets. This makes it very attractive for remote oil and gas production installations. However, it has been shown that it can save costs also for existing installations by replacing inspections at sections of installation, which are not piggable and difficult to approach. This is in general the case in oil and gas (offshore) production installations. Cost of inspection projects are extremely high in off shore environments and saving one inspection job can probably guarantee already your return on investment. Next, when using this technique it will also allow to make a wall thickness map of areas that are not accessible by current inspection techniques like corrosion under supports and feed through.
Recycled FPGA Detection Using Exhaustive LUT Path Delay Characterization and Voltage Scaling (2019)

Field-programmable gate arrays (FPGAs) have been extensively used because of their lower nonrecurring engineering and design costs, instant availability and reduced visibility of failure, high performance, and power benefits. Reports indicate that previously used or recycled FPGAs are infiltrating the electronics’ supply chain and making the security and reliability of the critical systems and networks vulnerable. Current recycled integrated circuit (IC) detection procedures include parametric, functional, and burn-in tests that require golden or reference data. Besides, they are time consuming, require expensive equipment, and do not focus on FPGAs. In this article, we propose two recycled FPGA detection methods based on supervised and unsupervised machine learning algorithms. We develop a sophisticated ring oscillator (RO) design to exploit the degradation of lookup tables (LUTs) and use them in the proposed methods. In the supervised method, a one-class classifier is trained with RO frequencies, kurtosis, and skewness data obtained from unused FPGAs, which differentiates unused and aged FPGAs. The unsupervised method uses $k$ -means clustering and Silhouette value analysis to detect suspect recycled components with very little (if any) golden information. In addition, we introduce a voltage scaling-assisted RO frequency measurement technique that improves the classification. The proposed methods are examined for Spartan-3A and Spartan-6 FPGAs, and the result shows that both methods are effective in detecting recycled FPGAs, which experience accelerated aging for at least 12 h equivalent to 70 days in real-time age.
Nonlinear Amplifier Distortion in Cooperative Amplify-and-Forward OFDM Systems (2009)

This paper studies receiver techniques for nonlinear amplifier distortion compensation in an OFDM relay-assisted cooperative communication system. The system model includes a nonlinear amplifier at the amplify-and-forward relay, modeled as a solid state power amplifier (SSPA). A maximum ratio combiner (MRC) is introduced that includes the effects of the amplifier distortions. The MRC is obtained by a proper modeling of the nonlinear distortion noise. Furthermore, we introduce a power amplifier nonlinearity cancellation (PANC) technique that is suitable for cooperative systems. Our simulation results confirm that the new MRC and PANC techniques offer substantial performance improvements if the relayed signal is subject to nonlinear distortion.
Isolated Coronary Artery Bypass Grafting in Obese Individuals - A Propensity Matched Analysis of Outcomes - (2011)

Obesity was associated with an increased risk of postoperative respiratory failure, postoperative renal failure, and surgical site infections. However, obesity was not associated with in-hospital mortality in patients undergoing CABG.
Abstract #3896: Growth inhibition of human lung cancer cells by Cucurbitacin B: potential mechanisms (2009)

Lung cancer is the most common cause of cancer mortality worldwide, with over 1.3 million deaths and continues to be a major health problem. Chemotherapeutic, radiation and surgical interventions have produced slight declines in mortality rates in recent years; however, it appears unlikely that additional marked improvements with these practices alone will occur in the near future. This grim overview urges powerfully for new, emerging approaches such as molecular or biologically targeted therapies and chemoprevention for the control of lung cancer. Over the recent years plant derived phytochemicals have gained increasing importance for their potential cancer chemopreventive and therapeutic activities. In this study we tested varied phytochemicals belonging to diverse chemical classes such as phenols, carotenoids, flavonoids, terpenoids, indoles, tocopherol/trienols, etc. for their antiproliferative effects on two non small cell lung cancer (NSCLC) cell lines, H1299 (p53 null) and A549 (p53 WT). The terpenoid compounds were found to be the most potent. One such terpenoid, Cucurbitacin B, (CuB) used in folk medicine for centuries for its wide spectrum of pharmacological activities was used in this study to gain mechanistic insights into its anticancer effects on the NSCLC cells. CuB, exhibited a significant dose-dependant inhibitory effect on the growth of both cell lines with IC 50 in low nanomolar range as assayed by MTT and Cy-Quant cell proliferation assays. The cells underwent rapid morphologic changes after 10-30 mins of exposure to CuB as evidenced by phase-contrast microscopy, which might be suggestive of the impairment of actin filament organization and microtubule disruption. To understand the molecular basis of the putative anticancer activity, we investigated the effects of CuB treatment on cell cycle distribution and apoptosis. Flow cytometric analysis showed a significant dose dependent arrest of cells in the G2/M phase ofthe cell cycle in as early as 8 hrs. The down regulation of checkpoint protein Cyclin B was well correlated with the cell cycle arrest at G2/M. Apoptosis, assayed by ethidium bromide and acridine orange fluorescence staining revealed signs of nuclear condensation, nuclei fragmentation, and membrane blebbing with CuB treatment. Western blot analysis showed a dose dependent downregulation of anti-apoptotic protein Bcl2 and the proteolytic cleavage of PARP (Poly (ADP-ribose) polymerase) that is a known downstream target of Caspase-3 activation and one of the hall mark feature associated with apoptosis. Taken together our results suggest that CuB exhibits pleotropic effects on the cells inducing both cell cycle arrest and apoptosis and can have therapeutic effects on both p53- and p53+ non small cell lung cancer. Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 3896.
Supplementary Figure 6 from Pericentromeric Instability and Spontaneous Emergence of Human Neoacrocentric and Minute Chromosomes in the Alternative Pathway of Telomere Lengthening (2023)

Supplementary Figure 6 from Pericentromeric Instability and Spontaneous Emergence of Human Neoacrocentric and Minute Chromosomes in the Alternative Pathway of Telomere Lengthening
Processing and Dielectric Properties of Sillenite Compounds Bi 12 MO 20−δ (M = Si, Ge, Ti, Pb, Mn, B 1/2 P 1/2 ) (2001)

Six sillenite compounds Bi 12 MO 20‐δ (M = Si, Ge, Ti, Pb, Mn, B 1/2 P 1/2 ) were synthesized, and the resulting single‐phase powders were then sintered to obtain ∼97% dense ceramics. An analysis of their microwave dielectric properties, performed at ∼5.5 GHz, revealed a permittivity of ∼40 for all six compounds. The temperature coefficient of resonant frequency was the lowest for the Pb analogue (−84 ppm/K) and was found to increase with increasing ionic radius of the B‐site ion to a value of −20 ppm/K for the Bi 12 SiO 20 and Bi 12 (B 1/2 P 1/2 )O 20 compounds. The Q × f value is a maximum for Bi 12 SiO 20 and Bi 12 GeO 20 with 8100 and 7800 GHz, respectively. The dielectric properties of the sillenites have been correlated with the structure of the oxygen network of the sillenite crystal lattice. As a result of its low sintering temperature (850°C), chemical compatibility with silver, low dielectric losses, and temperature‐stable permittivity, the Bi 12 SiO 20 compound is a suitable material for applications in low‐temperature cofiring ceramic (LTCC) technology.
Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia (2012)

The protein tyrosine phosphatase CD45, encoded by the PTPRC gene, is well known as a regulator of B- and T-cell receptor signaling. In addition, CD45 negatively regulates JAK family kinases downstream of cytokine receptors. Here, we report the presence of CD45 inactivating mutations in T-cell acute lymphoblastic leukemia. Loss-of-function mutations of CD45 were detected in combination with activating mutations in IL-7R, JAK1, or LCK, and down-regulation of CD45 expression caused increased signaling downstream of these oncoproteins. Furthermore, we demonstrate that down-regulation of CD45 expression sensitizes T cells to cytokine stimulation, as observed by increased JAK/STAT signaling, whereas overexpression of CD45 decreases cytokine-induced signaling. Taken together, our data identify a tumor suppressor role for CD45 in T-cell acute lymphoblastic leukemia.
pH dependence of methyl phosphonic acid, dipicolinic acid, and cyanide by surface-enhanced Raman spectroscopy (2004)

U.S. and Coalition forces fighting terrorism in Afghanistan and Iraq must consider a wide range of attack scenarios in addition to car bombings. Among these is the intentional poisoning of water supplies to obstruct military operations. To counter such attacks, the military is developing portable analyzers that can identify and quantify potential chemical agents in water supplies at microgram per liter concentrations within 10 minutes. To aid this effort we have been investigating the value of a surface-enhanced Raman spectroscopy based portable analyzer. In particular we have been developing silver-doped sol-gels to generate SER spectra of chemical agents and their hydrolysis products. Here we present SER spectra of methyl phosphonic acid and cyanide as a function of pH, an important factor affecting quantitation measurements, which to our knowledge has not been examined. In addition, dipicolinic acid, a chemical signature associated with anthrax-causing spores, is also presented.
Performance of CMS muon reconstruction in cosmic-ray events (2010)

MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA). Individuals have received support from the Marie-Curie IEF program (European Union); the Leventis Foundation; the A. P. Sloan Foundation; and the Alexander von Humboldt Foundation.
New complex space-time block codes for efficient transmit diversity (2002)

The two new methods of complex orthogonal space-time block coding are proposed, which make possible a more efficient transmit diversity with larger number of transmit antennas. The new space-time block codes, based on modulatable orthogonal sequences, have the minimum code length for a given number of antennas, resulting in the minimised complexity of the receiver.
Towards automatic drawing animation using physics-based evolution (2020)

We demonstrate a system to automatically animate hand-drawn characters. Starting with skeleton extraction, meshing and vertex skinning, our system simulates characters using a neural network in a physics-based environment. Using an evolutionary algorithm, it searches for networks that move characters far while keeping a good posture. We validated the system through a user study with 26 participants. For most drawings (60 %), they felt satisfied with the generated animation, and in 76% of cases, they wished to draw and animate additional characters. The participants reported mostly positive emotions after seeing the animations. Only a minority had feelings of strangeness or had negative emotions. This work demonstrates the possibility of creating an automated 2-D character animation system making little assumption on what is drawn. We believe that this work can enable more children to engage in creative play and explore their imagination.
Reproducibility of Nigh Vision Goggle Visual Acuity Measurements Using Landolt C's (1999)

Abstract : The main purpose of the study was to determine reproducibility limits of night vision goggle (NVG) acuity measurement under relatively high and low illumination levels. Psychometric acuity functions of three observers were repeatedly measured using Landolt C's as stimuli. The reproducibility limits of the Snellen acuity value (20/xx) relating to 50, 75 and 95% correct (adjusted for chance) were then determined. Reproducibility limit is defined as approximately 95% of all pairs of replications (20/xx) from the same illuminance and same observer, generated on different days, should differ in absolute value by less than the reproducibility limit. It was determined that for the lower illumination (8.61E-4 lux) at 50% corrected for chance probability level, the reproducibility limit was 5.1 Snellen acuity (20/xx) and for the higher illumination (1.38E- 2 lux), 2.5 Snellen acuity. These limits were 17% and 13% of mean acuity, respectively.