gebhart/patrepeval huggingface dataset:
A comparative study of the microstructure–dielectric properties of crystalline SrTiO3 ALD films obtained via seed layer approach (2011)

Abstract SrTiO 3 (STO) films were grown by atomic layer deposition (ALD) on TiN using Sr( t ‐Bu 3 Cp) 2 , Ti(OCH 3 ) 4 and H 2 O. After crystallization anneal, large single crystals grains were obtained and nanocracks were present. The microstructure can be changed using a thin STO crystalline seed spike annealed at 700 °C, which induces formation of much smaller grains in the top layer after post‐deposition anneal. The seed approach was also applied for a layer that was directly deposited in crystalline state at 370 °C, with a Ti(Me 5 Cp)(OMe) 3 precursor thermally stable at this temperature of deposition. The nanocracks were reduced or totally eliminated when using the seed layer template approach. Nevertheless, the leakage current is only reduced for the case when the Ti(OCH 3 ) 4 precursor was used.
Towards molecular stratification of pediatric T-cell lymphoblastic lymphomas based on Minimal Disseminated Disease and NOTCH1/FBXW7 mutational status: the French EURO-LB02 experience (2020)

Abstract While outcome for pediatric T lymphoblastic lymphoma (T-LBL) has improved with Acute Leukemia-type therapy, survival after relapse remains rare. Few prognostic markers have been identified and the value of Minimal Residual Disease (MRD) is less clear than in T-ALL. Mutations of NOTCH1 and/or FBXW7 ( N/F ) identify good prognosis T-LBL and both MRD and high-level Minimal Disseminated Disease (MDD) are reported to be of poor prognosis. We evaluated MDD status by 8-color flow cytometry (MFC) and/or digital droplet PCR (ddPCR) in 86 French pediatric T-LBL, of which N/F status was known for 65 (61 treated on the Euro-LB02 protocol). Both techniques gave identical results for MDD/MRD values above 0.1%, allowing compilation. While an MDD threshold of 1% had no prognostic significance, the 54% (44/82) of protocol-treated patients with MDD ≥0.1% had a relatively favorable outcome (overall survival/OS; p = 0.026). MDD 0.1% status had no prognostic significance in the 68% of patients with N/F mutations, whereas low/negative MDD status (9/61) identified N/F germline patients at a high risk of relapse (5-year OS of 44.4% vs 90% for MDD ≥ 0.1%,p = 0.014; and a 5-year DFS of 50% vs 90.9% respectively, p = 0.041). Combining oncogenetic and MDD status allows identification of 85% of patients with an excellent outcome (5-year OS 91.9% and DFS 95%) and 15% of N/F germline/MDD&lt; 0.1% patients who clearly require early alternative treatment (5-year OS 44.4%; p&lt; 0.0001 and DFS 50%; p = 0.0001).
The feasibility of manual parameter tuning for deformable breast MR image registration from a multi-objective optimization perspective (2017)

Deformable image registration is typically formulated as an optimization problem involving a linearly weighted combination of terms that correspond to objectives of interest (e.g. similarity, deformation magnitude). The weights, along with multiple other parameters, need to be manually tuned for each application, a task currently addressed mainly via trial-and-error approaches. Such approaches can only be successful if there is a sensible interplay between parameters, objectives, and desired registration outcome. This, however, is not well established. To study this interplay, we use multi-objective optimization, where multiple solutions exist that represent the optimal trade-offs between the objectives, forming a so-called Pareto front. Here, we focus on weight tuning. To study the space a user has to navigate during manual weight tuning, we randomly sample multiple linear combinations. To understand how these combinations relate to desirability of registration outcome, we associate with each outcome a mean target registration error (TRE) based on expert-defined anatomical landmarks. Further, we employ a multi-objective evolutionary algorithm that optimizes the weight combinations, yielding a Pareto front of solutions, which can be directly navigated by the user. To study how the complexity of manual weight tuning changes depending on the registration problem, we consider an easy problem, prone-to-prone breast MR image registration, and a hard problem, prone-to-supine breast MR image registration. Lastly, we investigate how guidance information as an additional objective influences the prone-to-supine registration outcome. Results show that the interplay between weights, objectives, and registration outcome makes manual weight tuning feasible for the prone-to-prone problem, but very challenging for the harder prone-to-supine problem. Here, patient-specific, multi-objective weight optimization is needed, obtaining a mean TRE of 13.6 mm without guidance information reduced to 7.3 mm with guidance information, but also providing a Pareto front that exhibits an intuitively sensible interplay between weights, objectives, and registration outcome, allowing outcome selection.
Cell spreading properties depend on cell passage number. (2015)

&lt;p&gt;RbCF2 and RbCF8 cells were serum starved for 48 h, trypsinized and then replated in presence of 10% serum for different post-plating times. Cells were fixed and cell morphology was analyzed. (A) Representative bright field images of RbCF2 and RbCF8 cells. (B) Graphs represent time-related changes in cell spreading behavior and (D) cell polarization. An average of 70 RbCF8 cells and 154 RbCF2 cells were analyzed. (C) Representative images of RbCF2 and RbCF8 cells at different times after plating and stained with phalloidin (red) and DAPI (blue). Scale bar = 35 μm at 30X magnification.&lt;/p&gt;
Applying BGP flowspec rules on a specific interface set (2015)

The BGP Flow Specification (flowspec) Network Layer Reachability
Information (BGP NLRI) extension ([RFC5575]) is used to distribute
traffic flow specifications into BGP. The primary application of this
extension is the distribution of traffic filtering policies for the
mitigation of distributed denial of service (DDoS) attacks. By
default, flow specification filters are applied on forwarding
interfaces that are enabled for use by the BGP flowspec extension. A
network operator may wish to apply a given filter selectively to a
subset of interfaces based on an internal classification scheme.
Examples of this include all customer interfaces, all peer
interfaces, all transit interfaces, etc. This document defines BGP
Extended Communities ([RFC4360]) that permit such filters to be
selectively applied to sets of forwarding interfaces sharing a common
group identifier. The BGP Extended Communities carrying this group
identifier are referred to as the BGP Flowspec interface-set
Extended Communities.
Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59 (2011)

Clinical studies have indicated that subvirion inactivated vaccines against avian influenza viruses, particularly H5N1, are poorly immunogenic in humans. As a consequence, the use of adjuvants has been championed for the efficient vaccination of a naïve population against avian influenza. Aluminum salts (alum) and the oil-in-water emulsion MF59 are safe and effective adjuvants that are being used with influenza vaccines, but the mechanism underlying their stimulation of the immune system remains poorly understood. It was shown recently that activation of a cytosolic innate immune-sensing complex known as "NLR-Pyrin domain containing 3" (NLRP3) inflammasome, also known as "cryopyrin," "cold-induced autoinflammatory syndrome 1" (CIAS1), or nacht domain-, leucine-rich repeat-, and PYD-containing protein 3 (Nalp3), is essential for the adjuvant effect of alum. Here we show that the inflammasome component apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), an adapter protein within the NLRP3 inflammasome, is a crucial element in the adjuvant effect of MF59 when combined with H5N1 subunit vaccines. In the absence of ASC, H5-specific IgG antibody responses are significantly reduced, whereas the responses are intact in NLRP3(-/-) and caspase-1(-/-) mice. This defect is caused mainly by the failure of antigen-specific B cells to switch from IgM to IgG production. We conclude that ASC plays an inflammasome-independent role in the induction of antigen-specific humoral immunity after vaccination with MF59-adjuvanted influenza vaccines. These findings have important implications for the rational design of next-generation adjuvants.
Small-Molecule “BRCA1-Mimetics” Are Antagonists of Estrogen Receptor-α (2014)

These findings suggest that we have identified a new class of ER-α antagonists that work differently from conventional antiestrogens (eg, tamoxifen and fulvestrant).
Metformin Preconditioning of Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells Promotes Their Engraftment and Improves Post-Stroke Regeneration and Recovery (2018)

While transplantation of human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSCs) shows therapeutic potential in animal stroke models, major concerns for translating hiPSC therapy to the clinic are efficacy and safety. Therefore, there is a demand to develop an optimal strategy to enhance the engraftment and regenerative capacity of transplanted hiPSC-NSCs to produce fully differentiated neural cells to replace lost brain tissues. Metformin, an FDA-approved drug, is an optimal neuroregenerative agent that not only promotes NSC proliferation but also drives NSCs toward differentiation. In this regard, we hypothesize that preconditioning of hiPSC-NSCs with metformin before transplantation into the stroke-damaged brain will improve engraftment and regenerative capabilities of hiPSC-NSCs, ultimately enhancing functional recovery. In this study, we show that pretreatment of hiPSC-NSCs with metformin enhances the proliferation and differentiation of hiPSC-NSCs in culture. Furthermore, metformin-preconditioned hiPSC-NSCs show increased engraftment 1 week post-transplantation in a rat endothelin-1 focal ischemic stroke model. In addition, metformin-preconditioned cell grafts exhibit increased survival compared to naive cell grafts at 7 weeks post-transplantation. Analysis of the grafts demonstrates that metformin preconditioning enhances the differentiation of hiPSC-NSCs at the expense of their proliferation. As an outcome, rats receiving metformin-preconditioned cells display accelerated gross motor recovery and reduced infarct volume. These studies represent a vital step forward in the optimization of hiPSC-NSC-based transplantation to promote post-stroke recovery.
Network segmentation in the cloud a novel architecture based on UCC and IID (2015)

Cloud Computing is known for its scalability, flexibility and on-demand workload creation. Today, cloud-enabled data centers utilize VLAN, VxLAN or GRE segmentations but these techniques, despite being widely deployed, have a variety of inherent technical and architectural limitations. In this paper we introduce a novel architecture leveraging UCC and IID for segmentation, rather than those traditionally used today (e.g., VLAN, VxLAN, etc.). The proposed architecture is entirely based on IPv6 and, for illustrative purposes only, is demonstrated using OpenStack as the cloud framework. This proposed reference architecture is based entirely on UCC and IID, two OpenStack-independent concepts, could easily be realized in outer cloud frameworks as well. UCC introduces cloud-specific traffic isolation within IPv6 extension headers. IIDs can be incorporated as a unique identifier within an IPV6 address to identify endpoints. The combination of both allows network devices to segregate traffic according to cloud service, cloud tenants and endpoint affiliation. Here, we highlight current shortcomings of existing segmentation techniques as well as define design considerations for the cloud framework in question (i.e. in this case OpenStack) to circumvent such limitations. The proposed architecture is depicted and explained in the context of a traffic flow example.
On the Thermomechanical Behavior of Ni60Ti40 Coupons via High Performance Full Field Experiments (2016)

Emerging applications for shape memory alloys, such as actuation and energy absorption devices, require better understanding of the mechanics and failure behaviors associated with these materials. In this paper we study the inelastic response of a NiTi alloy under combined thermomechanical actuation. In particular, failure due to strains generated by cooling under isobaric and isothermal conditions is investigated. Strain measurements are performed using a new technique known as Direct Strain Imaging, which provides full field strains of both higher accuracy and higher spatial resolution than previously achievable. The experimental data support the conclusion that the type of fracture observed may be attributed to stress redistribution, caused by a phase transformation.
Static multi-camera factorization using rigid motion (2009)

Camera networks have gained increased importance in recent years. Previous approaches mostly used point correspondences between different camera views to calibrate such systems. However, it is often difficult or even impossible to establish such correspondences. In this paper, we therefore present an approach to calibrate a static camera network where no correspondences between different camera views are required. Each camera tracks its own set of feature points on a commonly observed moving rigid object and these 2D feature trajectories are then fed into our algorithm. By assuming the cameras can be well approximated with an affine camera model, we show that the projection of any feature point trajectory onto any affine camera axis is restricted to a 13-dimensional subspace. This observation enables the computation of the camera calibration matrices, the coordinates of the tracked feature points, and the rigid motion of the object with a non-iterative trilinear factorization approach. This solution can then be used as an initial guess for iterative optimization schemes which make use of the strong algebraic structure contained in the data. Our new approach can handle extreme configurations, e.g. a camera in a camera network tracking only one single feature point. The applicability of our algorithm is evaluated with synthetic and real world data.
ChemInform Abstract: DEALKYLATION OF ZIRCONIUM(IV) BY BORANE: THE INTIMATE MECHANISM OF AN ALKYL TRANSFER REACTION (1982)

Abstract Mittels 1 H‐ und 11 B‐NMR‐Spektroskopie wird nachgewiesen, daß die Reaktion des Dimethyl‐Zr(IV)‐Komplexes (I) mit Boran zu dem Diborato‐ Derivat (III) durch Einschiebung von BH 3 in die Zr‐Me‐Bindung erfolgt und über mehrere Zwischenstufen verläuft, die koordinierte BH4‐"Me; enthalten wie z.B. das isolierbare (II).
Additions and Corrections - Rational Synthesis of Unidimensional Mixed Valence Solids. Structure Oxidation State-Charge Transport Relationships in Iodinated Nickel and Palladium Bisbenzoquinonedioximates. (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections - Rational Synthesis of Unidimensional Mixed Valence Solids. Structure Oxidation State-Charge Transport Relationships in Iodinated Nickel and Palladium Bisbenzoquinonedioximates.Leo Brown, Davida Kalina, Malcolm McClure, Steven Schultz, Stanley Ruby, James Ibers, Carl Kannewurf, and Tobin MarksCite this: J. Am. Chem. Soc. 1979, 101, 24, 7438–7439Publication Date (Print):November 1, 1979Publication History Published online19 February 2004Published inissue 1 November 1979https://doi.org/10.1021/ja00518a609RIGHTS & PERMISSIONSArticle Views15Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (237 KB) Get e-Alerts Get e-Alerts
Trust and Political Information: Attitudinal Change in Participants in the Youth Parliament in Brazil (2012)

This article analyses the impact of socializing experiences on the political attitudes of youngsters. More specifically, our goal is to evaluate the impact of the Youth Parliament program on youngsters’ confidence levels in the Minas Gerais State Assembly (MGSA). The analysis focuses on the cognitive foundations of attitudes and results show a substantial increase in confidence levels in MGSA, an increase associated with the acquisition of information on the institution. It is asserted that the increase in confidence in MGSA represents and attitudinal “gain”. The study design involves quasi-experimental research on a non-random sample. We conducted two rounds of interviews in 2008, prior and subsequent to the program, with 335 participants (167 in the treatment group; and 168 in the control group).
Hollow-core fibers for high power pulse delivery (2016)

We investigate hollow-core fibers for fiber delivery of high power ultrashort laser pulses. We use numerical techniques to design an anti-resonant hollow-core fiber having one layer of non-touching tubes to determine which structures offer the best optical properties for the delivery of high power picosecond pulses. A novel fiber with 7 tubes and a core of 30 mu m was fabricated and it is here described and characterized, showing remarkable low loss, low bend loss, and good mode quality. Its optical properties are compared to both a 10 mu m and a 18 mu m core diameter photonic band gap hollow-core fiber. The three fibers are characterized experimentally for the delivery of 22 picosecond pulses at 1032nm. We demonstrate flexible, diffraction limited beam delivery with output average powers in excess of 70W. (C) 2016 Optical Society of America
Sensitive Immunodetection of Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern 501Y.V2 and 501Y.V1 (2021)

Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants may influence the effectiveness of existing laboratory diagnostics. In the current study we determined whether the British (20I/501Y.V1) and South African (20H/501Y.V2) SARS-CoV-2 variants of concern are detected with an in-house S1-based antigen detection assay, analyzing spiked pools of quantitative reverse-transcription polymerase chain reaction-negative nasopharyngeal swab specimens. The assay, combining 4 monoclonal antibodies, allowed sensitive detection of both the wild type and the variants of concern, despite accumulation of several mutations in the variants' S1 region-results suggesting that this combination, targeting distinct epitopes, enables both specificity and the universality.
<title>NDI method to locate intergranular corrosion around fastener holes in aluminum wing skins</title> (1998)

Contact between galvanically dissimilar metals, such as cadmium plated steel fasteners and aluminum wing skins are known to be a source of corrosion. There is a design requirement to fill the void between the contacting surfaces of steel fasteners with a wet sealant. However, if the contacting surface is damaged or a void exists between the fastener head and the aluminum skin, moisture can collect and intergranular corrosion may occur along aluminum grain boundaries, which run parallel to the surface of the wing skin. If intergranular corrosion is allowed to propagate, delamination of the thin layers of aluminum, known as exfoliation corrosion will occur. When this intergranular corrosion reaches an exfoliated state, extensive rework is involved in removing the corrosion. This paper discusses the results of a USAF E-3A Engineering Service Task 89-E3B3-16 to develop a nondestructive inspection procedure to detect intergranular corrosion in an incipient state before it reaches exfoliation. Eddy current and ultrasonic inspection techniques were evaluated. A novel ultrasonic pulse echo technique was developed which utilizes a focus transducer with a hand held fixture. Inspections were performed on test parts which were removed from the upper wing skin of a retired 707 which had varying degrees of intergranular and exfoliation corrosion. Inspection results are compared to the results from the mechanical rework of the wing skin and dissection of a wing skin fastener hole.
Supplementary Figure 3 from The Novel Tryptamine Derivative JNJ-26854165 Induces Wild-Type p53- and E2F1-Mediated Apoptosis in Acute Myeloid and Lymphoid Leukemias (2023)

Supplementary Figure 3 from The Novel Tryptamine Derivative JNJ-26854165 Induces Wild-Type p53- and E2F1-Mediated Apoptosis in Acute Myeloid and Lymphoid Leukemias
Perfect and General Virtual Implementation For Perfectly Informed Players (2009)

We show that, when the players are perfectly informed about each other, essentially all social-choice functions can be rationally robustly implemented via an extensive-form public-action mechanism that (1) is perfectly robust against collusion, (2) requires only a linear number of computation steps and communication bits, and (3) preserves the privacy of the players' types to a very high extent.
Renewably sourced polytrimethylene ether glycol by superacid catalyzed condensation of 1,3-propanediol (2010)

In this paper we describe the synthesis of a new 100% renewably sourced polymer, polytrimethylene ether glycol (polyol). This is an alternative to petroleum-sourced polytetramethylene ether glycol (PTMEG) and polypropylene glycol (PPG) and adds to the slowly expanding list of polymers from renewables, such as polylactic acid. The polymer is based upon a renewably sourced monomer, 1,3-propanediol (PDO), which itself has a lower environmental footprint compared to the chemically derived monomer, with both lower amount of green house gas emissions and energy use, during formation. Herein we discuss the development of polymerization conditions to provide polytrimethylene ether glycol with low color and low unsaturated end groups using the superacid tetrafluoroethane sulfonic acid (TFESA, b.p. 212 °C). The initial high color (brown) and high unsaturated impurities of the polymer, has been overcome by careful control of the processing conditions, leading to a new class of 100% renewably-sourced polymers. Preliminary kinetic analyses are also reported.
Event handling in clean-slate Future Internet management (2009)

Event handling is a management mechanism that provides means for the network to react on changes in the network conditions or performance. In the construction of a clean-slate management architecture, we consider this as a main building block. This paper proposes a fully distributed event distribution in a fully distributed environment: differently from existing works, no configuration is required in advance, and yet nodes have guarantee that events are delivered and that certain delivery objectives are respected. The contributions of this paper are: a generic system model for event handling and an analysis of event distribution mechanisms with respect to timeliness and traffic metrics. The paper describes and discusses in detail the results based on simulations and provides guidelines for management functions of the Future Internet.