gebhart/patrepeval huggingface dataset:
A Comparison of the Adsorption and Diffusion of Hydrogen on the {111} Surfaces of Ni, Pd, and Pt from Density Functional Theory Calculations (2001)

We present gradient corrected density function theory calculations on the adsorption and thermally activated diffusion pathways of hydrogen on the {111} surfaces of Ni, Pd, and Pt. We find that the variation of the adsorption energy as a function of adsorption site shows considerable differences between the three metals. For Ni and Pd, the adsorption energies vary as a function of hydrogen coordination with the 3-fold hollow sites the most stable and the 1-fold atop site considerably less stable. On Pt the adsorption energies for all the sites are similar indicating that diffusion across the surface will be faster on Pt than on Ni or Pd. The activation energies for diffusion have been calculated with that for Pt (2−3 kJ mol-1) considerably smaller than for Ni or Pd (13 kJ mol-1). The calculated adsorption and activation energies are in good agreement with experimental investigations of the structure, energetics, and diffusion properties.
Metabolic and functional correlates of age-related hearing loss: advanced MRI findings and rehabilitation perspectives of the central auditory pathways (2021)

BACKGROUND: Presbycusis is the hearing loss (HL) determined by aging mechanisms affecting the inner ear. Auditory cortical hypoperfusion has been shown in the early phases of presbycusis, suggesting a regionally selective metabolic vulnerability secondary to peripheral loss of function. In this study, HL patients were stratified according to the audiogram profiles to possibly enable a finer regional characterization of cortical perfusion changes within the primary auditory cortex.METHODS: Sixty-two HL patients (age range: 47-78 years, PTA>50dB) and thirty-two normal hearing (NH) subjects (age-range 48-78 years) were enrolled in a 3 Tesla MRI study. Two clusters of HL patients were identified, and labeled as low-loss-high-slope (LLHS) and high-loss-low-slope (HLLS), according to the audiogram centro-types from an independent data set of fifty-five HL patients (age range: 45-80 years, PTA>50dB). Pseudo-continuous arterial spin labeling (ASL) and T1-weighted MRI were performed to derive cerebral blood flow (CBF) maps and to assess group-level perfusion changes within the primary auditory cortex.RESULTS: The comparison of CBF maps of all HL patients vs. NH controls confirmed a statistically significant CBF reduction in a compact region encompassing the right transverse temporal gyrus. The separate comparisons of LLHS and HLLS patients vs. NH subjects resulted in different localizations of the hypoperfusion region along the transverse temporal gyrus.CONCLUSIONS: Presbycusis is associated with perfusion reductions in the right primary auditory cortex with a different spatial pattern according to the audiogram profile. The observed heterogeneity of central auditory perfusion patterns may underlie different pathogenetic aspects and clinical forms of presbycusis.
Ability to Use Duplex US to Quantify Internal Carotid Arterial Stenoses: Fact or Fiction? (2000)

Doppler US is excellent for classifying stenoses as above or below a single degree of severity but does not function well in stenosis subclassification.
Effect of SCH 48461 on oral cholesterol absorption. (1996)

Clinical Pharmacology & Therapeutics (1996) 59, 194–194; doi: 10.1038/sj.clpt.1996.274
Polycrystalline Perovskite X-ray Detectors (2020)

Metal-halide perovskite materials have begun to attract much attention recently for their potential use in radiation detection applications. This interest is mainly due to their favourable semi-conductive properties, high electron density, ease of manufacture and relatively low cost compared to popular detector materials. In this paper we investigate inorganic caesium lead bromide (CsPbBr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ). Polycrystalline powder samples were produced by solution growth and simple `sandwich' devices were fabricated. The powder was manually ground and then pressed to form pellets of a few mm thickness. Gold planar electrodes were deposited on the top and bottom perovskite surfaces by evaporation and were connected to an external circuit. We have made comparative measurements of the photoluminescence (PL), dark current and temporal radiation response. The PL measurements showed stable emissions centred at 525 nm for CsPbBr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ' which is typical of these materials and within a useful range for this application. A CsPbBr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> device was exposed to X-rays and demonstrates a good increase in photocurrent over the dark current under both positive and negative bias with a sensitivity of 33.8 μCGy <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">air</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2 </sup> and the temporal response was determined to be ~40 ms by measuring the photocurrent decay after X-ray illumination.
AREA-Time Efficient Addition in Charge Based Technology (1981)

Using the model developed by Mead and Conway for charge based technology, a methodology for the production of area-time efficient adders which imbeds the buffering required to drive large loads caused by the carry-lookahead tree has been developed. This methodology can be used to produce an 0(logN) time and 0(NlogN) area layout. Additionally, an algorithm was written to produce minimal silicon area layouts for a given time bound. This algorithm involves optimization at both the cellular level and the layout level in an iterative fashion to allow the relevant technological parameters to play a role in the cellular design phase. Results of the algorithm including examples and an area-time curve for a 48 bit adder using typical 5 micron NMOS [MeCo80] are displayed.
Synthesis and characterization of a series of (pentamethylcyclopentadienyl)tungsten(V) and -(VI) amino, amido, imido, and bridging nitrido complexes and molybdenum analogs (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of a series of (pentamethylcyclopentadienyl)tungsten(V) and -(VI) amino, amido, imido, and bridging nitrido complexes and molybdenum analogsTimothy E. Glassman, Michael G. Vale, and Richard R. SchrockCite this: Organometallics 1991, 10, 12, 4046–4057Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/om00058a020https://doi.org/10.1021/om00058a020research-articleACS PublicationsRequest reuse permissionsArticle Views407Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
FLOW CYTOMETRIC ANALYSIS OF INTRACELLULAR CYTOKINE PRODUCTION IN RENAL TRANSPLANT RECIPIENTS (1999)

14 Despite advances in the prevention and treatment of acute rejection, accurate, non-invasive monitoring of the immune response remains an important target of transplantation research. Certain patterns of cytokine and effector molecule gene expression in graft and peripheral blood mononuclear cells (PBMCs) have previously been shown to correlate with episodes of acute rejection. Our group has already shown that flow cytometric analysis of Th1 and Th2 cytokine production in PBMCs is a potential useful marker of activity in autoimmune disease [J Clin Invest 1998 102: 671-8]. We examined patterns of cytokine production in patients on stable immunosuppression (n=27), greater that 9 months post renal transplantation using intracytoplasmic staining techniques as previously described [J Clin Invest 1998 102: 671-8]. A subset of these patients had chronic allograft nephropathy (CAN; n=9), defined as the presence of hypertension, creatinine >2.0mg/dL, proteinuria ± classical biopsy findings. Immunosuppressive regimens were equivalent in patients with and without CAN. Healthy, non-transplanted individuals were used as controls (n=12). PBMCs were isolated by density centrifugation and incubated for 6 hours with monensin (an inhibitor of cytokine export from the cell) ± mitogen (PHA, PMA and ionomycin). After staining of cell surface markers, cell membranes were permeablized, allowing staining of intracellular cytokines with specific anti-cytokine antibody. Cells were then analyzed using standard 2-color flow cytometry. The percentage of cytokine positive cells was calculated by subtracting the isotype control antibody signal from the specific anti-cytokine antibody signal. Results: There was a trend towards decreased production of IL-2 and IFNγ in lymphocytes from transplanted patients compared to healthy controls: 7.1±3.4 versus 13.3± 3.1 and 15.4±6.7 versus 21.0±11.9 respectively (all values mean±SD), presumably representing the effect of immunosuppressive drugs. The principal difference between transplanted patients with and without CAN was in lymphocyte production of IL-10 and in monocyte production of TGFβ (see table). Tableabove shows percentage of cells positive for a given cytokine in transplanted patients with or without CAN. Conclusion: These preliminary data suggest that CAN is associated with detectable alterations in cytokine/growth factor production in PBMCs. Ongoing studies will determine the clinical usefulness of this technique in the prospective monitoring of transplant patients. Type investigators and affiliations inside this box (Underline presenting author)Table
Implementation of an active vibration damping system for the SOFIA telescope assembly (2014)

The NASA/DLR Stratospheric Observatory for Infrared Astronomy (SOFIA) employs a 2.5-meter reflector telescope in a Boeing 747SP. The image stability goal for SOFIA is 0.2 arc-seconds. An active damping control system is being developed for SOFIA to reduce image jitter and degradation due to resonance of the telescope assembly. We describe the vibration control system design and implementation in hardware and software. The system’s unique features enabling system testing, control system design, and online health monitoring will also be presented.
Carina implantation in patients with mixed hearing loss: Influence of coupling site on speech comprehension (2020)

Introduction In patients with mixed hearing loss after multiple tympanoplasty and poor middle ear ventilation, fitting of conventional hearing aids is often failed due to the high hearing threshold . From an audiological point of view, implantable hearing aids provide a sufficient treatment option in these patients. In patients with medium to high-grade inner ear component, the fully implantable hearing aid Carina can close the supply gap because of its power characteristics.
Harmonic Current Reduction Control Based on Model Predictive Direct Current Control of IPMSM and Input Grid Circuit (2019)

This paper proposes a new inverter control method to reduce the input current harmonics and switching frequency of electrolytic capacitorless inverters for interior permanent magnet synchronous motor (IPMSM) drives. In an electrolytic capacitorless inverter system, the input current oscillates due to a resonance between the grid inductance and DC-link capacitor. Due to the oscillation in the input current caused by the LC resonance, the regulations for input current harmonics are sometimes not satisfied. The proposed method, which adopts a model predictive direct current control (MPDCC) method, reduces the switching frequency and satisfies the input current harmonics regulations IEC61000-3-2. MPDCC predicts the motor and input currents and evaluates them using a cost function to select a voltage vector. The cost function reduces the number of switching times and results in a current response that follows the current reference. The prediction model for input current is constructed using the state equations of the input LC resonance circuit and IPMSM. The effectiveness of the proposed method is confirmed experimentally. Further, the experimental results confirm that the proposed method satisfies the input current harmonics regulation IEC61000-3-2.
T cell therapy targeting a public neoantigen in microsatellite instable colon cancer reducesin vivotumor growth (2017)

T-cell receptor (TCR) transfer is an attractive strategy to increase the number of cancer-specific T cells in adoptive cell therapy. However, recent clinical and pre-clinical findings indicate that careful consideration of the target antigen is required to limit the risk of off-target toxicity. Directing T cells against mutated proteins such as frequently occurring frameshift mutations may thus be a safer alternative to tumor-associated self-antigens. Furthermore, such frameshift mutations result in novel polypeptides allowing selection of TCRs from the non-tolerant T-cell repertoire circumventing the problem of low affinity TCRs due to central tolerance. The transforming growth factor β Receptor II frameshift mutation (TGFβRII<sup>mut</sup>) is found in Lynch syndrome cancer patients and in approximately 15% of sporadic colorectal and gastric cancers displaying microsatellite instability (MSI). The -1A mutation within a stretch of 10 adenine bases (nucleotides 709-718) of the TGFβRII gene gives rise to immunogenic peptides previously used for vaccination of MSI+ colorectal cancer patients in a Phase I clinical trial. From a clinically responding patient, we isolated a cytotoxic T lymphocyte (CTL) clone showing a restriction for HLA-A2 in complex with TGFβRII<sup>mut</sup> peptide. Its TCR was identified and shown to redirect T cells against colon carcinoma cell lines harboring the frameshift mutation. Finally, T cells transduced with the HLA-A2-restricted TGFβRII<sup>mut</sup>-specific TCR were demonstrated to significantly reduce the growth of colorectal cancer and enhance survival in a NOD/SCID xenograft mouse model.
Reversible Ligand Exchange in a Metal–Organic Framework (MOF): Toward MOF-Based Dynamic Combinatorial Chemical Systems (2013)

Reversible benzene dicarboxylate/2-bromobenzene dicarboxylate ligand exchange has been studied in the cubic metal-organic framework MOF-5. Significant exchange (up to ∼50%), with continuous compositional variation, was observed using ex-situ (1)H NMR following treatment over ∼6 h at ∼85 °C in 10-40 mM ligand solutions. Exchange occurred without significant structural degradation as characterized by X-ray diffraction, nitrogen adsorption, and scanning electron microscopy. Solid-state (13)C NMR was used to show that exchanged ligands were incorporated into the framework lattice and not simply adsorbed within the pores. Exchange was found to be sensitive to the small free energy changes caused by the ligand concentration in the exchanging solution indicating that exchange is energetically nearly degenerate. This demonstration of reversible, nearly isoenergetic exchange indicates that mixed ligand MOFs could be developed as dynamic combinatorial chemical systems.
Enhancement of Interfacial Adhesion between Amorphous Polyamide and Polystyrene by in-Situ Copolymer Formation at the Interface (1994)

The enhancement of interfacial adhesion between immiscible amorphous polyamide and polystyrene (PS) by the addition of thin layers of styrene-maleic anhydride (SMA) random copolymer, used as a reactive compatibilizer, has been investigated. The asymmetric fracture test was employed to measure the fracture toughness of the interface as a function of the SMA amount placed at the interface. The fracture toughness of the interface between amorphous polyamide and bulk SMA remained low at all temperatures and annealing times of our experiment. When a thin layer of SMA was introduced between amorphous polyamide and PS, the fracture toughness was however remarkably increased as the amount of SMA layer and the annealing temperature were increased. This is believed to be due to copolymer formation at the interface due to reaction between the amine end group of the polyamide and the maleic anhydride (MAH) of SMA. A qualitative model is suggested for the combined effect of reaction at the interface and diffusion to obtain a strong interface. On the basis of this model, the experimental results obtained here are successfully divided into two regions: a diffusion-dominant region and a region in which the diffusion and the reaction at the interface are comparable, thus yielding a strong interface.
High-Resolution Lidar Using Random Demodulation (2018)

Recently emerging applications, such as autonomous navigation, mapping, and home entertainment, have increased the demand for inexpensive and high quality depth sensing. In this paper we fundamentally re-examine the problem, considering recent advances in photoelectric devices, increased availability of fast electronics, reduced computation cost, and developments in sensing theory. Our main contribution is a real-time hardware architecture for time-of- flight (ToF) depth sensors that exploits random modulation to significantly reduce the acquisition burden. The proposed design is able to acquire compressive, critical, or redundant measurements, without requiring any hardware modifications, at the expense of small reduction in the system frame rate. The architecture we propose is sufficiently flexible to be operable in a variety of conditions and with a variety of reconstruction algorithms.
Frequency on the Lifetime of a Surface ined Microe gine Driving a Load (1998)

Experiments have been performed on surface micromachined microengines driving load gears to determine the effect of the rotation frequency on median cycles to failure. We did observe a frequency dependence and have developed a model based on fundamental wear mechanisms and forces exhibited in resonant mechanical systems. Stressing loaded microengines caused observable wear in the rotating joints and in a few instances lead to fracture of the pin joint in the drive gear.
Distinct epitope structures of defensin‐like proteins linked to proline‐rich regions give rise to differences in their allergenic activity (2017)

Despite structural similarity, different IgE-binding profiles and proteolytic processing impacted the allergenic capacity of defensin-polyproline-linked molecules. Based on the fact that Amb a 4 demonstrated distinct IgE-binding epitopes, we suggest inclusion in molecule-based allergy diagnosis.
Characterization of the complete mitochondrial genomes of two sibling species of parasitic roundworms, Haemonchus contortus and Teladorsagia circumcincta. (2020)

Abstract Background Haemonchus contortus and Teladorsagia circumcincta are among the two most pathogenic internal parasitic nematodes infecting small ruminants, such as sheep and goats, and are a global animal health issue. Accurate identification and delineation of Haemonchidae species is essential for development of diagnostic and control strategies with high resolution for Trichostrongyloidea infection in ruminants. Here, we describe in detail and compare the complete mitochondrial (mt) genomes of the New Zealand H. contortus and T. circumcincta field strains to improve our understanding of species- and strain-level evolution in these closely related roundworms. Methods In the present study, we performed extensive comparative bioinformatics analyses on the recently sequenced complete mt genomes of the New Zealand H. contortus NZ_Hco_NP and T. circumcincta NZ_Teci_NP field strains. Amino acid sequences inferred from individual genes of each of the two mt genomes were compared, concatenated and subjected to phylogenetic analysis using Bayesian inference (BI), Maximum Likelihood (ML) and Maximum Parsimony (MP). Results The AT-rich mt genomes of H. contortus NZ_Hco_NP and T. circumcincta NZ_Teci_NP are 14,001 bp (A+T content of 77.4 %) and 14,081 bp (A+T content of 77.3 %) in size, respectively. All 36 of the typical nematode mt genes are transcribed in the forward direction in both species and comprise of 12 protein-encoding genes (PCGs), 2 ribosomal RNA ( rrn ) genes, and 22 transfer RNA ( trn ) genes. The secondary structures for the 22 trn genes and two rrn genes differ between H. contortus NZ_Hco_NP and T. circumcincta NZ_Teci_NP, however the gene arrangements of both are consistent with other Trichostrongylidea sequenced to date. Conclusions Comparative analyses of the complete mitochondrial nucleotide sequences, PCGs, A+T rich and non-coding repeat regions of H. contortus NZ_Hco_NP and T. circumcincta NZ_Teci_NP further reinforces the high levels of diversity and gene flow observed among Trichostrongylidea, and supports their potential as ideal markers for strain-level identification from different hosts and geographical regions with high resolution for future studies. The complete mt genomes of H. contortus NZ_Hco_NP and T. circumcincta NZ_Teci_NP presented here provide useful novel markers for further studies of the meta-population connectivity and the genetic mechanisms driving evolution in nematode species.
Stability by Fixed Point Theory in Consensus Dynamics]{Stability by Fixed Point Theory in Time Delayed Distributed Consensus Networks (2014)

We study the stability of linear time invariant distributed consensus dynamics in the presence of multiple propagation and processing delays. We employ fixed point theory (FPT) methods and derive sufficient conditions for asymptotic convergence to a common value while the emphasis is given in estimating the rate of convergence. We argue that this approach is novel in the field of networked dynamics as it is also flexible and thus capable of analyzing a wide variety of consensus based algorithms for which conventional Lyapunov methods are either too restrictive or unsuccessful.
In vitro DNA SCRaMbLE (2018)

The power of synthetic biology has enabled the expression of heterologous pathways in cells, as well as genome-scale synthesis projects. The complexity of biological networks makes rational de novo design a grand challenge. Introducing features that confer genetic flexibility is a powerful strategy for downstream engineering. Here we develop an in vitro method of DNA library construction based on structural variation to accomplish this goal. The "in vitro SCRaMbLE system" uses Cre recombinase mixed in a test tube with purified DNA encoding multiple loxPsym sites. Using a β-carotene pathway designed for expression in yeast as an example, we demonstrate top-down and bottom-up in vitro SCRaMbLE, enabling optimization of biosynthetic pathway flux via the rearrangement of relevant transcription units. We show that our system provides a straightforward way to correlate phenotype and genotype and is potentially amenable to biochemical optimization in ways that the in vivo system cannot achieve.