gebhart/patrepeval huggingface dataset:
Wire Bonding UPH and Stitch Bond Improvement using 20 Micron Diameter Insulated Wire with Security Bump (2010)

In this study, security bumps are used for strengthening the stitch bonds of two 20 micron diameter insulated Au wire bonding example processes. Bump bonding as a variant of the ball bonding process has been commonly used in the microelectronic industry to make bumps on dies that will later be flip-chip bonded. The optimized stitch bond parameters combined with the security bumps placed upon the stitch bonds substantially improve the second bond strength demonstrated on the two example processes on two different types of wire bonding equipment. A comparison of pull test results shows that security bumps increase stitch pull force up to 100%. The effect of varying the relative position (shift) of the security bump relative to the stitch bond location is investigated for one process. The window with the highest pull force improvement is ranging from 16 to 31 micron shift towards the ball bond. Looping with insulated wire is faster than with bare wire because of less effort to mitigate the risks of wires touching each other and producing a short. If two wire loops touch each other e.g. after molding, the wire insulation prevents shorts. Therefore, the looping requirements of the example processes with security bumps can be relaxed by reducing the number of kinks (reverses) from four to two. Due to the reduced looping complexity, the overall UPH increased with insulated wire by about 3.0 % and 4.9 % for the two processes, respectively. This increase is in spite of the time required for the additional security bumps, and compared to bare wire processes without security bumps but with more complex looping.
Intelligent Airbag Deployment (2012)

This C# program uses the Microsoft Kinect API, skeleton tracking, and face tracking * to determine driver biometrics.* * Notes: * * -Both RGB and infrared stream are converted to bitmap.* -Kinect Range Mode set to Near Mode * -Kinect skeleton tracking tracks head, center of shoulder, left shoulder, * right shoulder, right elbow, left elbow, right hand and left hand.* -Calculations are made between skeleton tracking points and arbitrary points * Abitrary points include: Center of Steering wheel depth frame * Top of Steering wheel in depth frame * Bottom of Passenger Seat * These arbitrary points are determined visually from a fixed Kinect position * on the test bed.* -Facial tracking shows pitch, yaw,
Acetylene- and Phenylacetylene-Terminated Poly(Arylene Ether Benzimidazole)s (PAEBI's) (1994)

Polymers prepared by first synthesizing polymers terminated with hydroxy groups, then reacting them with either 4-ethynylbenzoyl chloride or 4-fluoro-4'-phenylethynylbenzophenone. Endcapped polymers thermally cured to yield materials with attractive combination of properties. Cured acetylene-and phenylacetylene-terminated PAEBI's exhibit higher glass-transition temperatures and better retention of mechanical properties at high temperatures. Cured acetylene- and phenylacetylene-terminated polymers exhibit excellent adhesion to copper foil and polyimide film. Potentially useful as adhesives, coatings, composite matrices, fibers, films, membranes, and moldings.
Studies of the Interaction of Human Malaria Parasites with the Metabolism of the Host Red Cell. (1977)

Abstract : The purpose of the project was to try to determine if variation in host red cell metabolism could influence malaria severity, and whether information obtained could be used in developing new treatments. During the tenure of this contract, a number of studies of the interaction of malaria and red cell metabolism were carried out. This included in vitro interactions in a cultivation system, discussed in Section A, the relationship of the red cell ATP levels of ethnic groups to natural selection by malaria, (Section B), the relationship of the severity of malaria in rhesus monkeys to their red cell ATP levels (Section D), and the pronounced decrease in red cell ATP levels that occurs under some conditions in rodent malaries (Section D). A related study to this general theme was the development of a treatment of malaria involving hyperoxia which was effective in suppressing P vinckei in rats, but not P. berghei.
Diamond Stents for Palliation of Malignant Bile Duct Obstruction: A Prospective Multicenter Evaluation (2001)

The Diamond stent compares favorably with other biliary metal stents for patients requiring biliary drainage of malignant jaundice.
Molecular Electronics on Silicon: An Ultrahigh Vacuum Scanning Tunneling Microscopy Study (2003)

An ultrahigh vacuum scanning tunneling microscope (STM) was employed as a tool to characterize two distinct molecular electronic strategies on the Si(100) surface. Initially, the self-directed growth of one-dimensional styrene molecular chains on hydrogen-passivated Si(100) was investigated. High-resolution empty states imaging of these styrene nanostructures confirms alignment of phenyl groups along the chain. However, attempts at STM charge transport measurements were limited by tip induced desorption of styrene molecules. Consequently, an alternative oxygen radical chemistry was also investigated. In particular, the chemical adsorption of 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) onto clean Si(100) leads to the formation of an exceptionally stable silicon-oxygen bond that can withstand high bias charge transport measurements up to +/- 5 volts. Direct charge transport measurements through individual TEMPO molecules on degenerately n-type doped Si(100) reveal room temperature negative differential resistance behavior for negative sample biases exceeding - 3 volts.
CCDC 748475: Experimental Crystal Structure Determination (2010)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
ChemInform Abstract: Heteroatom‐Directed Lithiations of Chiral Alkyl Carbamates: A Powerful Tool for Enantioselective Synthesis (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection (2020)

In the present study, we analyzed the functional profile of CD8+ T-cell responses directed against autologous transmitted/founder HIV-1 isolates during acute and early infection, and examined whether multifunctionality is required for selection of virus escape mutations. Seven anti-retroviral therapy-naïve subjects were studied in detail between 1 and 87 weeks following onset of symptoms of acute HIV-1 infection. Synthetic peptides representing the autologous transmitted/founder HIV-1 sequences were used in multiparameter flow cytometry assays to determine the functionality of HIV-1-specific CD8+ T memory cells. In all seven patients, the earliest T cell responses were predominantly oligofunctional, although the relative contribution of multifunctional cell responses increased significantly with time from infection. Interestingly, only the magnitude of the total and not of the poly-functional T-cell responses was significantly associated with the selection of escape mutants. However, the high contribution of MIP-1β-producing CD8+ T-cells to the total response suggests that mechanisms not limited to cytotoxicity could be exerting immune pressure during acute infection. Lastly, we show that epitope entropy, reflecting the capacity of the epitope to tolerate mutational change and defined as the diversity of epitope sequences at the population level, was also correlated with rate of emergence of escape mutants.
Temperature-Dependent Admittance Analysis of HfO2 Gate Dielectrics on Nitrogen- and Sulfur-Passivated Ge (2006)

In this work, we characterize MOS capacitors with HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> gate dielectrics that utilize sulfur (S) passivation formed by pre-treatment of the Ge surface in an aqueous (NH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> ) <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2 </sub> S solution before HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> deposition, and compare the results with those using the more-standard N-passivation. Using temperature-dependent admittance measurements, we find that the S-passivated samples have lower minimum D <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">it</sub> and reduced flat-band shift, but also display larger accumulation dispersion and hysteresis than N-passivated samples. Results of admittance spectroscopy analysis also suggest that the energy distributions of the interface states are fundamentally different in the two sample types
PD51-11 REPORTING RADICAL CYSTECTOMY OUTCOMES FOLLOWING IMPLEMENTATION OF ENHANCED RECOVERY AFTER SURGERY (ERAS) PROTOCOLS (2020)

INTRODUCTION AND OBJECTIVE: Enhanced Recovery After Surgery (ERAS) is a perioperative approach to managing surgical patients. The impact of ERAS on radical cystectomy (RC) outcomes remains under-studied. Our goal was to systematically review the literature regarding ERAS protocols and RC outcomes. The primary outcome was hospital length of stay (LOS). METHODS: A systematic review was performed using Ovid and Medline for articles published from 1970 through 2018. Individual patient data (IPD) was requested from selected papers and meta-analysis undertaken. RESULTS: Overall, 4,197 articles were retrieved and 22 (0.5%) studies, reporting 3,847 patients, were selected for review. Of the 18 observational studies which met inclusion criteria, length of stay followed by 30 and 90-d complications were the most studied primary endpoints following implementation of ERAS protocols. Only one RC study to date has assessed the impact of all 26 ERAS items on RC outcomes. ERAS use was associated with reduced morbidity, quicker bowel recovery, and shorter LOS. ERAS resulted in no increased risk of mortality. IPD were obtained for 11 studies from 6 centers reporting 2,077 patients. In multivariate analysis, ERAS factors associated with an increased LOS included use of bowel preparation (Odds Ratio (OR): 5.11; 95% Confidence Interval (CI), 2.18-11.97, p<0.001), and use of nasogastric tube (NGT) postoperatively (OR: 3.19; 1.45-7.03, p=0.004), while the use of rectus sheath/local anesthesia blocks vs. spinal/epidural was associated with a shorter hospital stay (OR: 0.56; 0.35-0.91, p=0.020). CONCLUSIONS: Implementation of ERAS protocols was associated with reduced LOS and post-operative complication rate with no increased risk of mortality. Elimination of bowel preparation and NGT, and use of regional anesthesia were significantly associated with decreased LOS. These findings reflect different components of recovery which ERAS can optimize and further support documentation of use of ERAS components when reporting RC outcomes. Source of Funding: This study was conducted with the support of a Department of Defense Peer Reviewed Cancer Research Program (PRCRP) Career Development Award (W81XWH1710576) and the Herzog Foundation (SBW).
Improved Upper Bounds on the Reliability Function of the Gaussian Channel (2008)

A new lower bound on the distance distribution of spherical codes is derived. This yields two new upper bounds on the reliability function of the Gaussian channel. These bounds outperform previously known bounds, and imply a new range of rates for which the exact value of the reliability function is known.
MindMap: utilizing multiple taxonomies and visualization to understand a document collection (2003)

We present a novel system and methodology for browsing and exploring topics and concepts within a document collection. The process begins with the generation of multiple taxonomies from the document collections, each having a unique theme. We have developed the MindMap interface to the document collection. Starting from an initial keyword query, the MindMap interface helps the user to explore the concept space by first presenting the user with related terms and high level topics in a radial graph. After refining the query by selecting any related terms, one of the related high level concepts can be selected for further investigation. The MindMap uses a novel binary tree interface to explore the composition of a concept based on the presence or absence of terms. From the binary tree a concept can be further explored and visualized. Individual documents are presented as spatial coordinates where distance between points relates to document similarity. As the user browses this spatial representation, text is presented from the document that is most relevant to the user's initial query. Individual points can be selected to pull up the relevant paragraphs from the document with the keywords highlighted. Finally, selected documents are displayed and the user is allowed to further interact and investigate.
Additive Effects of 5-HTTLPR (Serotonin Transporter) and Tryptophan Hydroxylase 2 G-703T Gene Polymorphisms on the Clinical Response to Citalopram among Children and Adolescents with Depression and Anxiety Disorders (2013)

This finding suggests that 5-HTTLPR and TPH2 genes may act in concert to modulate the clinical response to citalopram among children and adolescents with depression and/or anxiety disorders.
Photodiode (2011)

Mit der Photodiode (PD) wird der Abschnitt des Buches über Lichtempfänger eröffnet. In Schaltungen werden PDs durch das Symbol dargestellt.
Self-sensing as an integration focus for motor drives and power devices (2007)

Self-sensing (sensorless or fully integrated sensing) methods in motor drives and power devices is a major opportunity to extend the early generations of fully integrated sensing to become central to the next generation of motor drive and power device design. To achieve the next level of integration, solutions that cross technology boundaries and are intrinsically multi-functional will be required, whereby the design-for-self- sensing in all actively controlled devices will be the norm. This paper and presentation will focus on the critical elements of the new multi-disciplinary self-sensing paradigm as it applies to both machine and power devices used in motor drives and all forms of power conversion equipment.
Phase I study of oral BKM120 and oral olaparib for high-grade serous ovarian cancer (HGSC) or triple-negative breast cancer (TNBC). (2014)

2510 Background: In vivo synergy of the PI3-kinase inhibitor BKM120 and the PARP inhibitor olaparib is seen using a mouse model of BRCA1-related breast cancer (BrCa) and sporadic TNBC (Juvekar et al and Ibrahim et al, Cancer Discovery 2012). The PI3kinase pathway is activated in both TNBC and HGSC (www.cancergenome.nih.gov). Olaparib is active in HGSC and germlineBRCA mutation (gBRCAm) ovarian cancer (OvCa) and gBRCAm BrCa. These data were the rationale for this phase I, multi-center study (NCT01623349) combining BKM120 and olaparib in patients (pts) with recurrent HGSC or TNBC. Methods: This study has a 3 + 3 design, escalating dose levels (DL) if 0/3 or 1/6 pts have a dose limiting toxicity (DLT) during the first cycle (1st 28 days). Objectives are to determine the MTD and RP2D of daily oral olaparib (tablet formulation) and BKM120, assess toxicities, preliminary activity of this combination, and PK profiles of both drugs. Planned translational endpts include PI3kinase pathway effects, BRCA1 immunostaining/methylation, IL-8/circulating DNA levels, and somatic mutations in BRCA1/2 using FFPE tissue. Eligibility included: recurrent TNBC or HGSC or any histology of OvCa or BrCa with presence of a gBRCAmut, PS 0-1, and measurable/evaluable cancer. Prior PARP inhibitor use was allowed. Results: 34 pts to date have received study drugs; 9 pts w/TNBC and 25 pts wHGSC. 26 have known gBRCAm. Dosing started at DL1 (BKM120 60 mg and olaparib 100 mg BID); 2 DLTs were observed (1 gr 3 LFTs and 1 gr 3 hyperglycemia). A lower dose (-1) was pursued followed by re-escalation as below. DL 6 was not feasible because of of grade 3 LFTs and grade 3 depression early in cycle 2. Evidence of clinical benefit by RECIST 1.1 was observed on all DL’s, and AEs seen were compatible with AE profile of BKM120 and olaparib. Expansion cohorts are accruing. Conclusions: Combined BKM120 and olaparib is feasible with evidence of clinical benefit seen at all DL’s. Further studies combining PARP and PI3kinase inhibitors are warranted. Clinical trial information: NCT01623349. Dose level Olaparib dose BID (mg) BKM120 dose qD (mg) # of patients 1 100 60 3 -1 50 40 6 2 100 40 7 3 150 50 3 4A 200 40 3 4B 150 50 3 5A 300 40 3 5B 200 50 3 6 (DLT dose) 300 60 3
Discrete logarithms, Diffie-Hellman, and reductions (2011)

Abstract. We consider the One-Prime-Not-p and All-Primes-But-p variants of the Discrete Logarithm (DL) problem in a group of prime order p. We give reductions to the Diffie-Hellman (DH) problem that do not depend on any unproved conjectures about smooth or prime numbers in short intervals. We show that the One-Prime-Not-p-DL problem reduces to DH in time roughly Lp(1/2); the All-Primes-But-p-DL problem reduces to DH in time roughly Lp(2/5); and the All-Primes-But-p-DL problem reduces to the DH plus Integer Factorization problems in polynomial time. We also prove that under the Riemann Hypothesis, with ε log p queries to a yes-or-no oracle one can reduce DL to DH in time roughly Lp(1/2); and under a conjecture about smooth numbers, with εlog p queries to a yes-or-no oracle one can reduce DL to DH in polynomial time. 1.
Perioperative Inpatient Use of Selective Serotonin Reuptake Inhibitors Is Associated With a Reduced Risk of THA and TKA Revision (2018)

Level III, therapeutic study.
Chirality correlation in double-wall carbon nanotubes as studied by electron diffraction (2006)

Structural correlation between two adjacent graphitic layers in double-wall carbon nanotubes (DWNTs) was systematically examined by using electron diffraction. Chiral angles and tube diameters were carefully measured, and the chiral indices of individual DWNTs were accurately determined. As a result, it was found that the interlayer distances of DWNTs were widely distributed in the range between 0.34 and $0.38\phantom{\rule{0.3em}{0ex}}\mathrm{nm}$. Chiralities of the inner and outer tubes tended to be distributed at higher chiral angles, approaching $30\ifmmode^\circ\else\textdegree\fi{}$, for the tubes with diameter $D&lt;\ensuremath{\sim}3\phantom{\rule{0.3em}{0ex}}\mathrm{nm}$. On the other hand, for the tubes with $D&gt;\ensuremath{\sim}3\phantom{\rule{0.3em}{0ex}}\mathrm{nm}$, the chiral angles were widely distributed, covering the chiral map entirely. Therefore, we consider that tubes with small diameters have a tendency to form armchair type. Correlation of chiralities between the inner and outer tubes was found to be random.
Radioimmunotargeting with modified streptavidin-biotin. Final report (1998)

For the past three years, the author has designed and produced several useful streptavidin variants, characterized their properties both in vitro and in vivo, and developed methods and strategies needed for characterization of each molecule and the entire radioimmunotargeting approaches using these molecules. In molecular design of these streptavidin mutants, an enhanced molecular modeling method, including empirical free energy calculations was used which is of great assistance in designing streptavidin mutants effectively and intelligently. When the original proposal was submitted in 1992, the reviewers were rather skeptical about the proposal to design successfully a various streptavidin mutants, particularly a dimeric streptavidin and multi-flavor streptavidins. These were clearly very challenging tasks, but now the author has the molecules in hand. This demonstrates the power of the molecular modeling method he is using and suggests the feasibility of further enhancements of these and other streptavidin variants by the molecular modeling capability. The author has also developed signal amplification methods which could introduce large amounts of radioisotopes specifically at target tumor sites in the radioimmunotargeting approaches.
Pulmonary arterial input impedance reflects the mechanical properties of pulmonary arterial remodeling in rats with pulmonary hypertension (2018)

The finding that changes in resistance were reciprocally associated with those in compliance indicates that resistant and compliant vessels are anatomically inseparable. The analysis of Z<sub>PA</sub> might help evaluate arterial remodeling in PH according to hemodynamics.
Chemistry of carbamoyl disulfide protected derivatives of proline* (1982)

High-yield methods have been devised for the synthesis of a series of alkyl and aryldithiocarbonyl derivatives of the alpha-imino acid proline. The carbamoyl disulfide protecting groups were rapidly and quantitatively removed under a variety of reductive conditions, suggesting their potential value for orthogonal schemes of peptide synthesis.
Vector Network Coding (2010)

We develop new algebraic algorithms for scalar and vector network coding. In vector network coding, the source multicasts information by transmitting vectors of length L, while intermediate nodes process and combine their incoming packets by multiplying them with L X L coding matrices that play a similar role as coding coefficients in scalar coding. Our algorithms for scalar network jointly optimize the employed field size while selecting the coding coefficients. Similarly, for vector coding, our algorithms optimize the length L while designing the coding matrices. These algorithms apply both for regular network graphs as well as linear deterministic networks.
Erratum: “Boundary condition applicable to free-standing quantum films” [J. Appl. Phys. 87, 1581 (2000)] (2000)

First Page
Small Business Development for Molecular Diagnostics (2011)

Molecular profiling, which is the application of molecular diagnostics technology to tissue and blood -specimens, is an integral element in the new era of molecular medicine and individualized therapy. Molecular diagnostics is a fertile ground for small business development because it can generate products that meet immediate demands in the health-care sector: (a) Detection of disease risk, or early-stage disease, with a higher specificity and sensitivity compared to previous testing methods, and (b) "Companion diagnostics" for stratifying patients to receive a treatment choice optimized to their individual disease. This chapter reviews the promise and challenges of business development in this field. Guidelines are provided for the creation of a business model and the generation of a marketing plan around a candidate molecular diagnostic product. Steps to commercialization are outlined using existing molecular diagnostics companies as learning examples.