gebhart/patrepeval huggingface dataset:
Readily useable bulk phenoxazine-based covalent organic framework cathode materials with superior kinetics and high redox potentials (2021)

Two p-type phenoxazine-based COFs with high discharge potentials (up to 3.6 V <italic>vs</italic>. Li/Li<sup>+</sup>) were achieved as directly usable cathode materials with superior active-site accessibility, ultrafast redox kinetics, and remarkable cycling stability.
Abstract 659: Chemerin Connects Fat to Blood Pressure (2012)

Obesity and hypertension have become comorbid in near epidemic proportion, yet their biological connection is still largely a mystery. We hypothesized that the peptide chemerin (TIG2) is a candidate for connecting fat deposits (both perivascular and visceral) to elevated blood pressure. The normal Sprague Dawley or deoxycorticosterone acetate salt (DOCA) rat was used as the model. Real time RT-PCR demonstrated that chemerin was synthesized in periadventitial fat (PVAT) around the aorta. Immunohistochemical experiments showed that the primary receptor for chemerin, ChemR23, was expressed in the tunica media and endothelial layer and not in resident inflammatory cells of the artery. The potent analog chemerin-9 (1 nM — 3 uM) caused a concentration-dependent isometric contraction in isolated aorta and superior mesenteric artery that was modest in tissues at baseline [∼6-11% phenylephrine (PE) maximum contraction] but significantly amplified in the presence of the nitric oxide synthase inhibitor nitro-L-arginine (LNNA; 2.5 fold increase in maximum), endothelial removal (5.95 fold increase) or agonist-induced tone (3.2 fold increase). Chemerin-induced contraction in tissues incubated with LNNA was concentration-dependently antagonized by the novel ChemR23 antagonist CCX832, demonstrating a new role for ChemR23. Arteries from the DOCA-salt hypertensive rat demonstrated endothelial dysfunction, and chemerin-induced maximum contraction from baseline was markedly increased in the aorta (DOCA = 16+3.6%, Sham = 6.7 + 2.2% PE contraction) and superior mesenteric artery (DOCA=57.9+12.8, Sham = 11.2+2.9 % PE contraction; p&lt;0.05). These data support a new role for chemerin as a vasoactive substance and a potential connector of the biological activity of the adipose tissue and liver (sources of chemerin) to blood pressure regulation, especially in conditions of endothelial dysfunction.
Differential Regulation by Toll-Like Receptor Agonists Reveals That<b><i> MCPIP1</i></b> Is the Potent Regulator of Innate Immunity in Bacterial and Viral Infections (2012)

Toll-like receptors (TLRs) are key molecules in innate immunity that recognize a variety of pathogen-associated molecular patterns. Activation of TLRs by their agonists initiates several signaling cascades, which eventually result in the expression of immune modifiers. Despite the fact that MCPIP1 is reported as an important immune regulator involved in macrophage activation, modulation of its expression by all known TLR agonists has never been documented. In this study, we present for the first time that in human monocyte-derived macrophages all TLR agonists, except CpG, markedly induced the expression of MCPIP1. The level of the induced transcript, as well as the protein and time of their appearance varied depending on the agonist. Furthermore, we confirmed the strong and differential upregulation of MCPIP1 during bacteria, virus and fungus infection. MCPIP1 belongs to a group of early-response genes; however, in the present study, we show for the first time the sustained high level of MCPIP1 expression during long-term Staphylococcus aureus infection. Taken together, our results implicate MCPIP1 as a potent regulator of innate immunity, which can be strongly engaged in the pathogenesis of acute and chronic infective diseases.
Supplementary Figure 4 from Pharmacokinetic and Pharmacodynamic Analysis of Circulating Biomarkers of Anti-NRP1, a Novel Antiangiogenesis Agent, in Two Phase I Trials in Patients with Advanced Solid Tumors (2023)

&lt;p&gt;PDF file, 51K, Ratio to baseline for plasma VEGF from the days 2 or 28 time points for all animals administered a single dose of MNRP1685A at varying dose levels. Each dose level contained n=4 animals. Plasma VEGF was measured using an MSD assay.&lt;/p&gt;
An Electrical Mine Monitoring System Utilizing the IEC 61850 Standard (2014)

Motor control assets are foundational elements in many industrial operations. In the mining industry, these assets primarily consist of motor control centers and drives, which are available with a comprehensive assortment of control and monitoring devices. Various intelligent electronic devices (IEDs) are now used to prevent machine damage and downtime. As motor control devices have advanced in technology, so too have the IEDs that protect them. These advances have resulted in new standards, such as the International Electrotechnical Commission (IEC) 61850, that have embedded intelligence and a standard set of communication schemes by which IEDs can share information in a peer-to-peer or one-to-many fashion. This paper discusses the merits and steps involved with interfacing IEDs to a mining process control network via the use of the IEC 61850 standard.
Axial Force And Deformation Of A Restrained Steel Beam In Fire : Description and validation of a simplified analytical procedure (2016)

Structural fire design is exceedingly adopting the performance based approach. There are evidentadvantages of this approach compared to the prescriptive methods from codes. An analytical procedure, ...
Synthesis and enzymatic evaluation of mucin type core 4 O-glycan. (2001)

Lactosylaminylated core-4 tetrasaccharide found in mucin type O-glycans has been synthesized . The non-reducing galactose residue of the deblocked tetrasaccharide was removed by beta-galactosidase from E. coli to produce the corresponding GlcNAc terminated compound. The core-2 and core-4 tetrasaccharides were evaluated as acceptors for the beta-1,3-N-acetylglucosaminyltransferase (iGnT), beta-1,4-Galactosyltransferase IV(beta4GalTIV) and beta-1,4-Galactosyltransferase I(beta4GalTI).
Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration (2019)

The human retinal pigment epithelium (RPE) and choroid are complex tissues that provide crucial support to the retina. Disease affecting either of these supportive tissues can lead to irreversible blindness in the setting of age-related macular degeneration. In this study, single-cell RNA sequencing was performed on macular and peripheral regions of RPE-choroid from 7 human donor eyes in 2 independent experiments. In the first experiment, total RPE/choroid preparations were evaluated and expression profiles specific to RPE and major choroidal cell populations were identified. As choroidal endothelial cells represent a minority of the total RPE/choroidal cell population but are strongly implicated in age-related macular degeneration (AMD) pathogenesis, a second single-cell RNA-sequencing experiment was performed using endothelial cells enriched by magnetic separation. In this second study, we identified gene expression signatures along the choroidal vascular tree, classifying the transcriptome of human choriocapillaris, arterial, and venous endothelial cells. We found that the choriocapillaris highly and specifically expresses the regulator of cell cycle gene (<i>RGCC</i>), a gene that responds to complement activation and induces apoptosis in endothelial cells. In addition, <i>RGCC</i> was the most up-regulated choriocapillaris gene in a donor diagnosed with AMD. These results provide a characterization of the human RPE and choriocapillaris transcriptome, offering potential insight into the mechanisms of choriocapillaris response to complement injury and choroidal vascular disease in age-related macular degeneration.
Une colonie de peuplement au XVIIIe siècle: les luxembourgeois dans le Banat hongrois (autour de Timisoara) (1998)

info:eu-repo/semantics/published
An algorithm to extract blood-pressure waveform features during intra-aortic balloon pump assist (2003)

An adaptive, real-time algorithm that detects clinically important features of blood pressure (BP) waveforms and yields accurate BP measurements during intra-aortic balloon pump (IABP) support is presented. The algorithm uses an existing electrocardiogram (ECG) or ECG synch output signal in identifying BP beat features. The algorithm is compared with algorithms used in four commercial cardiovascular monitors, using data previously recorded from patients on IABP support. The features extracted by the present algorithm are found to estimate BP parameters better than commercial monitors.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
C−C Bond Formation via C−H Bond Activation:  Synthesis of the Core of Teleocidin B4 (2002)

The core of teleocidin B4, a complex fragment of a natural product containing two quaternary stereocenters and a penta-substituted benzene ring, was synthesized in four C-C bond-forming steps starting from tert-butyl derivative 1. The first step involved alkenylation of the tert-butyl group with a vinyl boronic acid, followed by the successful annulation of the cyclohexane ring to the benzene nucleus via an intramolecular Friedel-Crafts reaction. The third step required a diastereoselective oxidative carbonylation of the geminal dimethyl group, followed at last by indole assembly via the alkenylation of the phenol nucleus, to afford the teleocidin B4 core. Noteworthy is the fact that steps 1 and 3 critically depended on the directing role of the aniline nitrogen (directed C-H bond functionalization).
RF Filter using Boundary Acoustic Wave (2006)

In this paper, we report a new structure of a shear horizontal (SH) type boundary acoustic wave for cellular phone applications. Such a structure composed of electrodes with a low shear wave velocity between two materials, namely, the SiO2 film/Au-electrode/LiNbO3 substrate, is proposed. The ladder filter used in this paper had this structure. By changing the propagation angle of the acoustic wave, the electromechanical coupling factor k2 range from 0 to 16% was obtained, as well as a normalized bandwidth range 0.67 to 1.85 fold as large as that of a 36–46°Y–X LiTaO3 leaky surface acoustic wave (LT-LSAW) filter. In addition, an excellent temperature coefficient of delay time (TCD=25 ppm/°C) and a large mutual coupling coefficient κ12 (=0.15) were also obtained.
A chemically-defined screening platform reveals behavioral similarities between primary human mesenchymal stem cells and endothelial cells (2012)

Chemically defined substrates, which rigorously control protein-surface and cell-surface interactions, can be used to probe the effects of specific biomolecules on cell behavior. Here we combined a chemically-defined, array-based format with automated, time-lapse microscopy to efficiently screen cell-substrate interactions. Self-assembled monolayers (SAMs) of alkanethiolates bearing oligo(ethylene glycol) units and reactive terminal groups were used to present cell adhesion peptides while minimizing non-specific protein interactions. Specifically, we describe rapid fabrication of arrays of 1 mm spots, which present varied densities of the integrin-binding ligand Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP). Results indicate that cell attachment, cell spreading, and proliferation exhibit strong dependencies on GRGDSP density for both human mesenchymal stem cells (hMSCs) and human umbilical vein endothelial cells (HUVECs). Furthermore, relative spreading and proliferation over a broad range of GRGDSP densities were similar for both primary cell types, and detailed comparison between cell behaviors identified a 1 : 1 correlation between spreading and proliferation for both HUVECs and hMSCs. Finally, time-lapse microscopy of SAM arrays revealed distinct adhesion-dependent migratory behaviors for HUVECs and hMSCs. These results demonstrate the benefits of using an array-based screening platform for investigating cell function. While the proof-of-concept focuses on simple cellular properties, the quantitative similarities observed for hMSCs and HUVECs provides a direct example of how phenomena that would not easily be predicted can be shown to correlate between different cell types.
Human blood basophils synthesize interleukin-2 binding sites (1990)

Recent data suggest that basophils express receptors for a variety of lymphokines. In this study we present the biochemical characterization of the interleukin-2 (IL-2) receptor on the basophil surface membrane. Highly enriched populations (purity: 92% to 99%) of blood basophils were obtained from chronic granulocytic leukemia (CGL) patients (n = 3) by negative selection using monoclonal antibodies (MoAbs) and complement. CGL basophils were found to bind CD25 MoAbs (n = 4) directed against different epitopes of the 55- to 60-Kd subunit of the IL-2 receptor (= Tac peptide). Immunoprecipitation experiments with lysates of purified CGL basophils and CD25 MoAbs showed a protein with a molecular weight of 60 Kd, equivalent to the Tac peptide on human T blasts. Quantitative binding studies and Scatchard plot analysis using radiolabeled recombinant human (rh) IL-2 indicated the presence of 12,000 +/- 4,700 low affinity IL-2 binding sites (kd = 66 nmol/L) per purified CGL basophil. Northern blot analysis with enriched CGL basophils showed two messenger RNA bands of 3.5 and 1.5 kilobases hybridizing to radiolabeled Tac cDNA. Immunoprecipitation of the Tac peptide from enriched basophils metabolically labeled with 35S-methionine showed active synthesis of the IL-2 receptor. Our results show that human blood basophils synthesize and express receptors for IL-2.
Thermal metasurface with tunable narrowband absorption from a hybrid graphene/silicon photonic crystal resonance (2022)

We report the design of a tunable, narrowband, thermal metasurface that employs a hybrid resonance generated by coupling a tunable permittivity graphene ribbon to a silicon photonic crystal. The gated graphene ribbon array, proximitized to a high quality factor Si photonic crystal supporting a guided mode resonance, exhibits tunable narrowband absorbance lineshapes (Q > 10,000). Actively tuned Fermi level modulation in graphene with applied gate voltage between high absorptivity and low absorptivity states gives rise to absorbance on/off ratios exceeding 60. We employ coupled-mode theory as a computationally efficient approach to elements of the metasurface design, demonstrating an orders of magnitude speedup over typical finite element computational methods.
References to remote mobile objects in Thor (1993)

Thor is a distributed object-oriented database where objects are stored persistently at highly available servers called object repositories, or ORs. In a large Thor system, performance tuning and system reconfiguration dictate that objects must be able to migrate among ORs. The paper describes two schemes for object references that support object migration, one using location-independent names and the other, location-dependent names. The paper analyzes the performance of the two schemes and concludes that location-dependent names are the right choice for systems like Thor, where we want fast access to objects that have migrated.
Synthesis and Biological Evaluation of Some Acyclic Pyridine C-Nucleosides. Part Two (1996)

Abstract 3-Bromo-5-(2-hydroxyethylthiomethyl)pyridine (7) was synthesized by reaction of 3-bromo-5-chloromethylpyridine hydrochloride (6) with the mono sodium salt of 2-mercaptoethanol. 3-Bromo-5-hydroxymethylpyridine (10) was, after protection as a silyl ether, converted to the 3-carboxy analogue using BuLi and CO2. After deprotection with NH4F, the alcohol function was chlorinated using SOCl2. Finally, attachment of the acyclic chain and ammonolysis gave the acyclic nicotinamide nucleosides. Treatment of the latter compounds with Lawesson's reagent gave the thioamide analogues. All compounds were identified by NMR and DCI-MS. The acyclic pyridine C-nucleosides were evaluated against a series of tumor-cell lines and a variety of viruses. No marked biological activity was found.
Stochasticity of particle orbits in a collective particle accelerator (1985)

A detailed investigation of the behavior of particle orbits in the simultaneous presence of three large amplitude waves such as those encountered in the Collective Particle Accelerator (CPA) experiment is undertaken. Stochasticity arising out of the resonance overlap of the waves can influence the particle dynamics significantly and thereby affect the outcome of the experimental results. Choice of initial phase and energy for successful operation is identified and discussed. Keywords: Relativistic electron beam; Stochasticity; Collective accelerator.
Enantioselective Organocatalytic Conjugate Addition of Amines to α,β‐Unsaturated Aldehydes: One‐Pot Asymmetric Synthesis of β‐Amino Acids and 1,3‐Diamines. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Biocompatibility and resorption of a radiopaque premixed calcium phosphate cement (2012)

Calcium phosphate cements (CPC) are used as bone void filler in various orthopedic indications; however, there are some major drawbacks regarding mixing, transfer, and injection of traditional CPC. By using glycerol as mixing liquid, a premixed calcium phosphate cement (pCPC), some of these difficulties can be overcome. In the treatment of vertebral fractures the handling characteristics need to be excellent including a high radio-opacity for optimal control during injection. The aim of this study is to evaluate a radiopaque pCPC regarding its resorption behavior and biocompatibility in vivo. pCPC and a water-based CPC were injected into a Ø 4-mm drilled femur defect in rabbits. The rabbits were sacrificed after 2 and 12 weeks. Cross sections of the defects were evaluated using histology, electron microscopy, and immunohistochemical analysis. Signs of inflammation were evaluated both locally and systemically. The results showed a higher bone formation in the pCPC compared to the water-based CPC after 2 weeks by expression of RUNX-2. After 12 weeks most of the cement had been resorbed in both groups. Both materials were considered to have a high biocompatibility since no marked immunological response was induced and extensive bone ingrowth was observed. The conclusion from the study was that pCPC with ZrO(2) radiopacifier is a promising alternative regarding bone replacement material and may be suggested for treatment of, for example, vertebral fractures based on its high biocompatibility, fast bone ingrowth, and good handling properties.
Abstract 955: Musashi-2 regulates EGFR expression in NSCLC, cell proliferation and survival, response to EGFR inhibitors in EGFR-mutant NSCLC (2019)

Abstract Musashi-2 (MSI2) is an RNA-binding protein that regulates mRNA translation. We recently established that MSI2 is elevated in a subset of non-small cell lung cancer (NSCLC) tumors upon progression and drives NSCLC metastasis, in part based on activity supporting a TGF-beta/SMAD3/claudin signaling cascade. Here, reverse phase protein array (RPPA) analysis of MSI2-depleted versus control KrasLA1/+;P53R172HΔG/+ murine NSCLC cell lines identified a significant upregulation of HER3 (ERBB3) upon MSI2 depletion. Negative MSI2-dependent regulation of ERBB3 protein was confirmed in multiple murine and human NSCLC models, based on analysis of MSI2 depletion or overexpression. Further, MSI2 positively regulated expression of the epidermal growth factor receptor (EGFR) protein in the same models. Comparing EGFR and KRAS driven models, we found that MSI2 depletion significantly impairs cell proliferation and clonogenicity only in EGFR-mutant NSCLC cell lines. Using RNA immunoprecipitation analysis coupled with qPCR, we show that MSI2 directly binds to EGFR and, to a lesser extent, to HER3 mRNA. MSI2 mRNA binding was correlating with the presence of predicted MSI2 binding sites in corresponding mRNAs. Taken together, this data suggest direct regulation of EGFR protein expression by MSI2 at post transcriptional level. NSCLC lung tissue microarray immunohistochemistry analysis revealed that MSI2 total positivity by H-score, 2+/3+ and 3+ positivity correlated with EGFR 3+ staining. Finally, EGFR inhibitors erlotinib and afatinib synergized with MSI2 depletion in EGFR mutant models, suggesting that therapeutic targeting of MSI2 could be of clinical value, especially in EGFR-mutant lung cancer. In vivo experiments of erlotinib treatments of wild type or MSI2 depleted tumors are ongoing and these results will be presented. Citation Format: Alexander Kudinov, Petr Makhov, Bulat Faezov, Igor Bychkov, Alexander Deneka, Emmanuelle Nicolas, Kathy Q Q. Caid, Rohan Brebione, Eleanor Avrilf, Anna S. Nikonova, Ilya G. Serebriiskii, Hossein Borghaei, Erica A. Golemis, Yanis Boumber. Musashi-2 regulates EGFR expression in NSCLC, cell proliferation and survival, response to EGFR inhibitors in EGFR-mutant NSCLC [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 955.
Performance of a 0.13 µm SOI integrated 60 GHz dipole antenna (2007)

4 pages
In Vitro Evidence for the Dual Function of Alg2 and Alg11:  Essential Mannosyltransferases in N-Linked Glycoprotein Biosynthesis (2006)

The biosynthesis of asparagine-linked glycoproteins utilizes a dolichylpyrophosphate-linked glycosyl donor (Dol-PP-GlcNAc(2)Man(9)Glc(3)), which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. This biosynthetic pathway is highly conserved throughout eukaryotic evolution. While complementary genetic and bioinformatic approaches have enabled identification of most of the dolichol pathway enzymes in Saccharomyces cerevisiae, the roles of two of the mannosyltransferases in the pathway, Alg2 and Alg11, have remained ambiguous because these enzymes appear to catalyze only two of the remaining four unannotated transformations. To address this issue, a biochemical approach was taken using recombinant Alg2 and Alg11 from S. cerevisiae and defined dolichylpyrophosphate-linked substrates. A cell-membrane fraction isolated from Escherichia coli overexpressing thioredoxin-tagged Alg2 was used to demonstrate that this enzyme actually carries out an alpha1,3-mannosylation, followed by an alpha1,6-mannosylation, to form the first branched pentasaccharide intermediate of the pathway. Then, using thioredoxin-tagged Alg2 for the chemoenzymatic synthesis of the dolichylpyrophosphate pentasaccharide, it was thus possible to define the biochemical function of Alg11, which is to catalyze the next two sequential alpha1,2-mannosylations. The elucidation of the dual function of each of these enzymes thus completes the identification of the entire ensemble of glycosyltransferases that comprise the dolichol pathway.
Randomized Controlled Trial of Resection Versus Radiotherapy After Induction Chemotherapy in Stage IIIA-N2 Non-Small-Cell Lung Cancer (2007)

In selected patients with pathologically proven stage IIIA-N2 NSCLC and a response to induction chemotherapy, surgical resection did not improve overall or progression-free survival compared with radiotherapy. In view of its low morbidity and mortality, radiotherapy should be considered the preferred locoregional treatment for these patients.