gebhart/patrepeval huggingface dataset:
Multiple Bonds between Main-Group Elements and Transition Metals. 136. "Polymerization" of an Organometal Oxide: The Unusual Behavior of Methyltrioxorhenium(VII) in Water (1995)

ADVERTISEMENT RETURN TO ISSUEPREVarticleNEXTMultiple Bonds between Main-Group Elements and Transition Metals. 136. "Polymerization" of an Organometal Oxide: The Unusual Behavior of Methyltrioxorhenium(VII) in WaterWolfgang A. Herrmann and Richard W. FischerCite this: J. Am. Chem. Soc. 1995, 117, 11, 3223–3230Publication Date (Print):March 1, 1995Publication History Published online1 March 1995Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/ja00116a026https://doi.org/10.1021/ja00116a026research-articleACS PublicationsCopyright © 1995 American Chemical SocietyRequest reuse permissionsArticle Views295Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biodegradable Polyelectrolyte Microcapsules: Antigen Delivery Tools with Th17 Skewing Activity after Pulmonary Delivery (2009)

Because of their large surface area, the lungs appear an attractive route for noninvasive vaccine delivery, harboring the potential to induce local mucosal immune responses in addition to systemic immunity. To evoke adaptive immunity, Ags require the addition of adjuvants that not only enhance the strength of the immune response but also determine the type of response elicited. In this study, we evaluate the adjuvant characteristics of polyelectrolyte microcapsules (PEMs) consisting of the biopolymers dextran-sulfate and poly-L-arginine. PEMs form an entirely new class of microcapsules that are generated by the sequential adsorption of oppositely charged polymers (polyelectrolytes) onto a sacrificial colloidal template, which is subsequently dissolved leaving a hollow microcapsule surrounded by a thin shell. Following intratracheal instillation, PEMs were not only efficiently taken up by APCs but also enhanced their activation status. Pulmonary adaptive immune responses were characterized by the induction of a strongly Th17-polarized response. When compared with a mixture of soluble Ag with empty microcapsules, Ag encapsulation significantly enhanced the strength of this local mucosal response. Given their unique property to selectively generate Th17-polarized immune responses, PEMs may become of significant interest in the development of effective vaccines against fungal and bacterial species.
Complex Interactions between the Major and Minor Envelope Proteins of Equine Arteritis Virus Determine Its Tropism for Equine CD3+T Lymphocytes and CD14+Monocytes (2010)

Extensive cell culture passage of the virulent Bucyrus (VB) strain of equine arteritis virus (EAV) to produce the modified live virus (MLV) vaccine strain has altered its tropism for equine CD3(+) T lymphocytes and CD14(+) monocytes. The VB strain primarily infects CD14(+) monocytes and a small subpopulation of CD3(+) T lymphocytes (predominantly CD4(+) T lymphocytes), as determined by dual-color flow cytometry. In contrast, the MLV vaccine strain has a significantly reduced ability to infect CD14(+) monocytes and has lost its capability to infect CD3(+) T lymphocytes. Using a panel of five recombinant chimeric viruses, we demonstrated that interactions among the GP2, GP3, GP4, GP5, and M envelope proteins play a major role in determining the CD14(+) monocyte tropism while the tropism for CD3(+) T lymphocytes is determined by the GP2, GP4, GP5, and M envelope proteins but not the GP3 protein. The data clearly suggest that there are intricate interactions among these envelope proteins that affect the binding of EAV to different cell receptors on CD3(+) T lymphocytes and CD14(+) monocytes. This study shows, for the first time, that CD3(+) T lymphocytes may play an important role in the pathogenesis of equine viral arteritis when horses are infected with the virulent strains of EAV.
Chemical potential and quantum Hall ferromagnetism in bilayer graphene (2014)

Bilayer graphene has a distinctive electronic structure influenced by a complex interplay between various degrees of freedom. We probed its chemical potential using double bilayer graphene heterostructures, separated by a hexagonal boron nitride dielectric. The chemical potential has a nonlinear carrier density dependence and bears signatures of electron-electron interactions. The data allowed a direct measurement of the electric field-induced bandgap at zero magnetic field, the orbital Landau level (LL) energies, and the broken-symmetry quantum Hall state gaps at high magnetic fields. We observe spin-to-valley polarized transitions for all half-filled LLs, as well as emerging phases at filling factors ν = 0 and ν = ±2. Furthermore, the data reveal interaction-driven negative compressibility and electron-hole asymmetry in N = 0, 1 LLs.
Study of the Impact of H+Mobile Ions on RF Performances of PECVD TEOS Silicon Dioxide Deposited at Low Temperature (2016)

International audience
Optimization of a p-Coumaric Acid Biosensor System for Versatile Dynamic Performance (2020)

Metabolic engineering is a promising approach for the synthesis of valuable compounds. Transcriptional factor-based biosensors are efficient tools to regulate the metabolic pathway dynamically. Here, we engineered the <i>p</i>-coumaric acid responsive regulator PadR from <i>Bacillus subtilis</i>. We found that <i>yveF</i> and <i>yveG</i>, two previously uncharacterized components in the sensor system, showed positive impacts on the regulation of PadR-P<sub>padC</sub> sensor system, mostly on assisting the release of the repression by PadR. By site directed PadR engineering, we obtained two mutants, K64A and H38A, which exhibited increased dynamic range and superior sensitivity. To increase the promoter strength of the sensor system and investigate whether the PadR binding boxes can function in a "plug-and-play" manner, a series of hybrid promoters were constructed. Four of them, P1, P2, P7, and P9, showed increased strength compared to P<sub>padC</sub> and can be regulated by PadR and <i>p</i>-coumaric acid. The PadR variants and hybrid promoters obtained in this paper would expand the applicability of this sensor system in future metabolic engineering research.
Development and characterization of Th17-related U-PLEX® assays (2016)

Abstract Th17-related cytokines mediate a host’s defense mechanisms against various infections and play a crucial role in crosstalk between the immune system and affected tissues. Here we describe the development and characterization of multiplexed Th17-related immunoassays on MSD’s flexible U-PLEX platform. Monoclonal and polyclonal antibodies were conjugated with biotin and/or SULFO-TAG™ and screened as capture and/or detection reagents. A number of analytical parameters were used to select antibody pairs, and assays were developed by optimizing antibody concentrations, calibrator curves, specificity, matrix tolerance, and assay robustness. Assay performance was verified to be compatible with other U-PLEX assays by running Th17-related multiplexes on the U-PLEX platform with controls and samples. Calibration curves showed expected signals, sensitivity, precision, and accuracy. Control samples for the assays had CVs &amp;lt; 10% within runs and &amp;lt; 25% between runs. Sensitivities were &amp;lt; 1 pg/mL for the majority of the assays. Dilution linearity and spike recovery studies demonstrated acceptable matrix tolerance and accurate quantification for most of the assays tested across all matrices (typically between 75% – 125%). Cross-reactivity between assays was shown to be typically &amp;lt; 0.5%. Results demonstrated a strong correlation between samples measured on U-PLEX multiplex and streptavidin singleplex panels with r2 values &amp;gt; 0.95 and slopes between 0.8–1.2. Over 20 Th17-related assays for human and mouse were developed for the U-PLEX platform. These assays enable the measurement of multiple proteins on biological matrices that are relevant to a wide range of life science applications and pre-clinical or clinical studies.
Quantifying Infant Lean Body Mass using Free-Breathing 3D Stack-of-Radial MRI (2023)

Lean body mass (LBM) is an important measure of metabolic ability. Decreased LBM during infancy may be associated with impaired growth and increased risk for future metabolic disease. This study measured skeletal muscle area as a surrogate for LBM in infants using free-breathing MRI. Psoas and paraspinal muscle areas were measured in 14 infants at the L4-L5 intervertebral disc level. Cross-sectional area of the thigh muscles was measured at the right midthigh in 8 infants. Infants with higher birth weights and those born large for gestational age had larger muscle areas than infants born lighter and/or small for gestational age.
A Discussion on the Role of Decision Support in a Location Analysis Case Study (2014)

In this paper, we discuss a case study regarding transfer stations siting in a Solid Waste Management System, building a multi-criteria model potentially adequate to the involvement of multiple actors. A Decision Support System (DSS), named SABILOC ([1]), integrating an Interactive Bi-objective Integer Programming Module and a Multi-attribute Module is used. The last module allows an a posteriori more detailed analysis of the solutions selected during the first module. Furthermore, the DSS includes meaningful graphical tools and integrates a Geographic Information System (GIS).
Distribution of interstitial cells of Cajal and nitrergic neurons in normal and diabetic human appendix (2007)

The objective of this study was to determine the distribution of enteric nerves and interstitial cells of Cajal (ICC) in the normal human appendix and in type 1 diabetes. Appendixes were collected from patients with type 1 diabetes and from non-diabetic controls. Volumes of nerves and ICC were determined using 3-D reconstruction and neuronal nitric oxide synthase (nNOS) expressing neurons were counted. Enteric ganglia were found in the myenteric plexus region and within the longitudinal muscle. ICC were found throughout the muscle layers. In diabetes, c-Kit positive ICC volumes were significantly reduced as were nNOS expressing neurons. In conclusion, we describe the distribution of ICC and enteric nerves in health and in diabetes. The data also suggest that the human appendix, a readily available source of human tissue, may be useful model for the study of motility disorders.
Evaluation of Electronic Microarrays for Genotyping Factor V, Factor II, and MTHFR (2003)

Mutation detection using the NanoChip Molecular Biology Workstation was accurate and reproducible for the three assays evaluated.
Effect of Particles Drift on Dendritic Growth (2014)

With the use of diffusion-limited aggregation modeling, we have investigated the effect of particle drift for dendritic growth. It is found that the morphology of dendritic growth is sensitive to the particle drift, i.e., the larger drift effect results in the denser growth of dendrite. From the analysis using the correlation function, we found the fractional dimension of each dendrite increases as the particles drift increases. Furthermore, we showed the height of dendrite significantly decrease for the slight change of particles drift. Finally, we discussed the strategy to reduce dendritic growth by modifying the transport properties of electrolytes.
Sequence Heterogeneity of Nef Transcripts in HIV-1-Infected Subjects at Different Stages of Disease (1996)

Nef transcripts were analyzed from peripheral blood mononuclear cells of 10 HIV-1-infected subjects with 9-822 CD4+ lymphocytes/cu mm, including 4 individuals with a probable common source infection. There was no relationship between the phylogenetic position of the various nef sequences and the disease state of the person from whom they were derived. The nef open reading frame was disrupted in all three clones from only 1 subject. Functional analyses of a representative clone from each of the remaining 9 subjects showed that all nef alleles were capable of CD4 cell surface down-regulation, but only three nef alleles suppressed the induction of IL-2 transcription.
System design optimization for multimegawatt space nuclear power applications (1990)

The results of a design and optimization study of the Pellet Bed Reactor System Concept (PBRSC) for meeting the multimegawatt power needs of some Strategic Defense Initiative (SDI) missions during both alert and burst modes of operation are presented. The power system consists of four modules, each capable of providing up to 165 MWe during the burst mode and 3.3 MWe during the alert mode. This modular approach provides redundancy, with low-mass penalty, and it increases the power plant's survivability by requiring an attack force to destroy many independent power modules. Results indicate that the specific power of a hydrogen-cooled Pellet Bed Reactor/potassium Rankine cycle module (3.8 kWe/kg) is superior to a closed-loop Brayton cycle module (3.1 kWe/kg), but comparable with an open-loop Brayton cycle module (3.8 kWe/kg). The comparison established that the closed-loop Brayton cycle module needs about 10 times higher compressor power than the Rankine cycle module, resulting in a lower specific power. Additionally, the savings in the radiator mass resulting from the higher efficiency of the closed-loop Brayton cycle module (20% vs 17% for Rankine cycle module) is offset by the higher heat rejection load caused by the higher reactor thermal power to compensate for the higher compressor power. Analysis also established that the combined masses of the hydrogen tank and the attached refrigeration unit of the open-loop Brayton cycle module favorably compare with those of the radiator and the vapor generator for the Rankine cycle module.
Dynamics of anterior–posterior axis formation in the developing mouse embryo (2012)

The development of an anterior-posterior (AP) polarity is a crucial process that in the mouse has been very difficult to analyse, because it takes place as the embryo implants within the mother. To overcome this obstacle, we have established an in-vitro culture system that allows us to follow the step-wise development of anterior visceral endoderm (AVE), critical for establishing AP polarity. Here we use this system to show that the AVE originates in the implanting blastocyst, but that additional cells subsequently acquire AVE characteristics. These 'older' and 'younger' AVE domains coalesce as the egg cylinder emerges from the blastocyst structure. Importantly, we show that AVE migration is led by cells expressing the highest levels of AVE marker, highlighting that asymmetry within the AVE domain dictates the direction of its migration. Ablation of such leading cells prevents AVE migration, suggesting that these cells are important for correct establishment of the AP axis.
Indoor Millimeter-Wave Systems: Design and Performance Evaluation (2020)

Indoor areas, such as offices and shopping malls, are a natural environment for initial millimeter-wave (mmWave) deployments. Although we already have the technology that enables us to realize indoor mmWave deployments, there are many remaining challenges associated with system-level design and planning for such. The objective of this article is to bring together multiple strands of research to provide a comprehensive and integrated framework for the design and performance evaluation of indoor mmWave systems. This article introduces the framework with a status update on mmWave technology, including ongoing fifth generation (5G) wireless standardization efforts and then moves on to experimentally validated channel models that inform performance evaluation and deployment planning. Together these yield insights on indoor mmWave deployment strategies and system configurations, from feasible deployment densities to beam management strategies and necessary capacity extensions.
Particle Rotation in Early Sintering (1984)

Shrinkage and rearrangement during the early stages of sintering are considered. In such rearrangement the sintering particles can experience both additional center‐to‐center stresses and bending moments arising from multiparticle interactions and asymmetrical neck formation. The response of a particle pair to the simultaneous action of these stresses is solved analytically in a cylindrical geometry.
Analyse de scène sonore multi-capteurs : un front-end temps-réel pour la manipulation de scène (2017)

The context of this thesis is the development of spatialized audio (5.1 contents, Dolby Atmos...) and particularly of 3D audio. Among the existing 3D audio formats, Ambisonics and Higher Order Ambisonics (HOA) allow a homogeneous spatial representation of a sound field and allows basics manipulations, like rotations or distorsions. The aim of the thesis is to provides efficient tools for ambisonics and HOA sound scene analyse and manipulations. A real-time implementation and robustness to reverberation are the main constraints to deal with. The implemented algorithm is based on a frame-by-frame Independent Component Analysis (ICA), wich decomposes the sound field into a set of acoustic contributions. Then a bayesian classification step is applied to the extracted components to identify the real sources and the residual reverberation. Direction of arrival of the sources are extracted from the mixing matrix estimated by ICA, according to the ambisonic formalism, and a real-time cartography of the sound scene is obtained. Performances have been evaluated in different acoustic environnements to assess the influence of several parameters such as the ambisonic order, the frame length or the number of sources. Accurate results in terms of source localization and source counting have been obtained for frame lengths of a few hundred milliseconds. The algorithm is exploited as a pre-processing step for a speech recognition prototype and allows a significant increasing of the recognition results, in far field conditions and in the presence of noise and interferent sources.
Calibrating accelerometers using an Electromagnetic Launcher (2012)

A Pulse Forming Network (PFN), Helical Electromagnetic Launcher (HEML), Command Module (CM), and Calibration Table (CT) were built and evaluated for the combined ability to calibrate an accelerometer. The PFN has a maximum stored energy of 19.25 kJ bank and is fired by a silicon controlled rectifier (SCR), with appropriate safety precautions. The HEML is constructed out of G-10 fiberglass and is designed to accelerate 600 grams to 10 meters per second. The CM is microcontroller based running Arduino Software. The CM has a keypad input and 7 segment outputs of the bank voltage and desired voltage. After entering a desired bank voltage, the CM controls the charge of the PFN. When the two voltages are equal it allows the fire button to send a pulse to the SCR to fire the PFN and in turn, the HEML. The HEML projectile's tip hits a target that is held by the CT. The CT consists of a table to hold the PFN and HEML, a vacuum chuck, air bearing, velocity meter and catch pot. The Target is held with the vacuum chuck awaiting impact. After impact, the air bearing allows the target to fall freely for the velocity meter to get an accurate reading. A known acceleration is determined from the known change in velocity of the target. Thus, if an accelerometer was attached to the target, the measured value can be compared to the known value.
Le concept « une seule santé », définition, relations homme-animal-environnement en parasitologie et en émergences virales (2019)

Jestin André, Dupouy-Camet Jean. Le concept « une seule santé », définition, relations homme-animal-environnement en parasitologie et en émergences virales. In: Bulletin de l'Académie Vétérinaire de France tome 172, 2019. pp. 110-111.
Interaction of the heart and its close and distant neighbours: report of the Meeting of the ESC Working Groups Myocardial Function and Cellular Biology (2013)

Intercellular and inter-organ communication is required to maintain homoeostasis in multicellular organisms. Given its life-supporting function, the heart is at the centre of a heavily studied network of interactions. Despite the long-recognized ability to receive and relay inputs to and from far and close neighbours, surprising new networks of interactions as well as new communication factors and mechanisms are currently emerging. The Myocardial Function and the Cellular Biology of the Heart Working groups of the European Society of Cardiology convened during 2–5 May 2013 to discuss emerging data and ongoing studies on intercellular and inter-organ communication, in health and disease.

Cells interact through either direct contact or secreted agonists. The signal transduction machinery inside cells eventually translates interactions with limited numbers of agonists into a cellular response. This process of scanty molecules being pinpointed by high-affinity receptors is now flanked by other emerging mechanisms of communication that involve highly abundant messengers binding to relatively low-affinity detectors. Two novel intercellular communication paths are currently arising: the flooding of cells with secreted vesicles, the so-called exosomes, with various but information-rich contents, and the sensing of different species of circulating RNA, such as miRNAs that, once captured, elicit post-transcriptional regulation of gene expression, and the extracellular RNAs (eRNA) that, from the outside of cells, trigger membrane enzyme activation and generation of classical receptor agonists.

### 2.1 Exosomes and miRNA

An exciting new concept in the field of intercellular and inter-organ communication is the idea that microscopic vesicles may ferry proteins and RNA through interstitial fluid and blood. Building on this concept, miRNA and proteins from plasma microvesicles and exosomes may offer a great potential as biomarkers for cardiovascular risk and cellular injury. Specific miRNAs act as master regulators of angiogenesis, cardiomyocyte proliferation, and regulation of cell survival. In particular, the importance of miR-199, which seems to regulate a …
Onboard Detection of Snow, Ice, Clouds and Other Geophysical Processes Using Kernel Methods (2003)

The detection of clouds within a satellite image is essential for retrieving surface geophysical parameters from optical and thermal imagery.
Effect of Boron to Magnesium Ratio on Green Color Emissions in Pyrotechnics (2022)

American Chemical Society National Meeting, Virtual, August 22-26, 2021