gebhart/patrepeval huggingface dataset:
High Soluble Thrombomodulin Is Associated with an Increased Risk of Major Bleeding during Treatment with Oral Anticoagulants: A Case–Cohort Study (2020)

High sTM levels at the start of treatment are associated with major bleeding during vitamin K antagonist treatment, particularly in the presence of a high INR.
Manipulating light on a silicon chip (2004)

We demonstrate ultra-fast compact low power devices on silicon. The devices include electro-optic, all-optical and bistable modulators. These devices enhance the electro-optical and non-linearities properties of silicon using light confinement effects.
Stereoselectivity for the (R)‐Enantiomer of HA‐966 (l‐Hydroxy‐3‐Aminopyrrolidone‐2) at the Glycine Site of the N‐Methyl‐d‐Aspartate Receptor Complex (1990)

HA-966 (1-hydroxy-3-aminopyrrolidone-2) is an antagonist at the glycine allosteric site of the N-methyl-D-aspartate receptor ionophore complex. Unlike presently known glycine antagonists, HA-966 is chiral. We report stereoselectivity for the (R)-enantiomer at the glycine antagonist site. In [3H]glycine binding, the (R)-enantiomer has an IC50 of 4.1 +/- 0.6 microM. The racemic mixture has an IC50 of 11.2 +/- 0.5 microM, whereas (S)-HA-966 has an IC50 greater than 900 microM. In glycine-stimulated [3H]1-[1-(2- thienyl)cyclohexyl]piperidine binding, the (R)-enantiomer inhibits with an IC50 of 121 +/- 61 microM, whereas the racemic mixture has an IC50 of 216 +/- 113 microM and (S)-HA-966 is inactive. The inhibition by (R)-HA-966 can be prevented by the addition of glycine. (R)-HA-966 and racemic HA-966, but not (S)-HA-966, also prevent N-methyl-D-aspartate cytotoxicity in cortical cultures. The (R)-enantiomer and, less potently, the (S)-enantiomer inhibit N-methyl-D-aspartate-evoked [3H]norepinephrine release from rat hippocampal slices (IC50 values of about 0.3 mM and 1.6 mM, respectively), but only the inhibition by (R)-HA-966 is reversed by added glycine. In glutamate-evoked contractions of the guinea pig ileum, (R)-HA-966 causes a glycine-reversible inhibition (IC50 of about 150 microM), whereas (S)-HA-966 is much less potent (IC50 of greater than 1 mM). These results demonstrate stereoselectivity of the glycine antagonist site of the N-methyl-D-aspartate receptor complex in a variety of tissues and assays. The stereoselectivity also confirms the specificity of N-methyl-D-aspartate receptors in glutamate-evoked contractions of the guinea pig ileum, and supports their similarity to central N-methyl-D-aspartate receptors.
Quantitive Evaluation and Control of Delamination and Change in the Physico-chemical Properties of Talc by Wet Grinding. (1996)

Delamination and changes in the physico-chemical properties in the grinding of talc were studied using a multi-ring media grinding machine. Products were characterized by SEM, specific surface area, St and aspect ratio, As, determined from the Heywood diameter and thickness measured by a confocal scanning laser microscope. The change in the physico-chemical properties were examined by thermogravimetry and X-ray diffractometry. As and St increase with the increasing rate of revolution. The former levels off at above ca. 1000min-1, while the latter keeps increasing. When the St of products exceeds three times that of the starting material, the crystal structure and the physico-chemical properties of talc change remarkably, indicating the change from the delamination region to the size reduction region. The change between these two operational regions is shown to be controlled by selecting the grinding condition.
Dynamics of chemical vapor sensing with MoS2using 1T/2H phase contacts/channel (2016)

Ultra-thin transition metal dichalcogenides (TMDs) films show remarkable potential for use in chemical vapor sensing devices. Electronic devices fabricated from TMD films are inexpensive, inherently flexible, low-power, amenable to industrial-scale processing because of emergent growth techniques, and have shown high sensitivity and selectivity to electron donor analyte molecules important for explosives and nerve gas detection. However, for devices reported to date, the conductance response to chemical vapors is dominated by Schottky contacts, to the detriment of the sensitivity, selectivity, recovery, and obscuring their intrinsic behavior. Here, we use contact engineering to transition the contacts in a MoS2 FET-based chemical vapor sensor to the 1T conducting phase, while leaving the channel in the 2H semiconducting state, and thus providing Ohmic contacts to the film. We demonstrate that the resultant sensors have much improved electrical characteristics, are more selective, and recover fully after chemical vapor exposure-all major enhancements to previously MoS2 sensor devices. We identify labile nitrogen-containing electron donors as the primary species that generate a response in MoS2, and we study the dynamics of the sensing reactions, identifying two possible qualitative models for the chemical sensing reaction.
Patterns of Ship-borne Species Spread: A Clustering Approach for Risk Assessment and Management of Non-indigenous Species Spread (2014)

The spread of non-indigenous species (NIS) through the global shipping network (GSN) has enormous ecological and economic cost throughout the world. Previous attempts at quantifying NIS invasions have mostly taken "bottom-up" approaches that eventually require the use of multiple simplifying assumptions due to insufficiency and/or uncertainty of available data. By modeling implicit species exchanges via a graph abstraction that we refer to as the Species Flow Network (SFN), a different approach that exploits the power of network science methods in extracting knowledge from largely incomplete data is presented. Here, coarse-grained species flow dynamics are studied via a graph clustering approach that decomposes the SFN to clusters of ports and inter-cluster connections. With this decomposition of ports in place, NIS flow among clusters can be very efficiently reduced by enforcing NIS management on a few chosen inter-cluster connections. Furthermore, efficient NIS management strategy for species exchanges within a cluster (often difficult due higher rate of travel and pathways) are then derived in conjunction with ecological and environmental aspects that govern the species establishment. The benefits of the presented approach include robustness to data uncertainties, implicit incorporation of "stepping-stone" spread of invasive species, and decoupling of species spread and establishment risk estimation. Our analysis of a multi-year (1997--2006) GSN dataset using the presented approach shows the existence of a few large clusters of ports with higher intra-cluster species flow that are fairly stable over time. Furthermore, detailed investigations were carried out on vessel types, ports, and inter-cluster connections. Finally, our observations are discussed in the context of known NIS invasions and future research directions are also presented.
Isolation of a cDNA encoding thymic shared antigen-1. A new member of the Ly6 family with a possible role in T cell development. (1993)

We have previously characterized a novel mouse thymocyte marker, defined as thymic shared Ag-1 (TSA-1), present on both immature thymocytes and a subset of thymic medullary epithelial cells. MTS 35, a mAb specific for TSA-1, alters T cell differentiation when added to fetal thymic organ cultures, suggesting TSA-1 may be important for T cell development in the thymus. In this study, we describe the isolation of a cDNA encoding TSA-1 using transient expression of COS-7 cells and selection with MTS 35. The predicted amino acid sequence of this cDNA encodes a 15 to 17-kDa protein and the expressed protein is linked to the membrane via a phosphatidylinositol moiety. TSA-1 is transcriptionally active at various levels in all organs examined, suggesting that its role is not solely intrathymic. TSA-1 shares amino acid sequence homology to the mouse Ly6 multigene family, epidermal growth factor-like receptors, and to cobra venom neurotoxin. The Tsa-1 locus is located on chromosome 15 linked to Ly6 on the mouse genome. We also examined the effects of MTS 35 in fetal thymic organ cultures repopulated with two subsets of thymocytes representing defined stages of T cell development. Our results suggest that TSA-1 may play a role during positive selection and the transition from CD4+CD8+ thymocytes to the mature CD4+CD8- and CD4-CD8+ subsets.
Humanized anti-DEspR IgG4S228P antibody increases overall survival in a pancreatic cancer stem cell-xenograft peritoneal carcinomatosis ratnu/nu model (2021)

Collectively, the data support humanized anti-DEspR hu-6g8 as a potential targeted antibody-therapeutic with promising efficacy, safety and prevalence profiles for PPC patients.
New Toe Sleeve Enables True Casing-Pressure Test in an Eagle Ford Shale Well: A Case Study (2015)

Abstract The Eagle Ford Shale in the southern part of Texas is a carbonate-rich, oil-producing, organic shale. Typically, wells are drilled horizontally through the target section of the Eagle Ford shale formation. A long string production casing is then run and cemented in place. A plug and perforate completion helps enable hydraulic fracturing of multiple target intervals along the lateral section of the wellbore. Before fracturing the wellbore, pressure testing of the casing string to the maximum fracturing pressure has become an industry best practice. Then, a flow path is created at the toe of the wellbore using tubing-conveyed perforating (TCP) guns run into the wellbore on coiled tubing (CT). With the constant drive to improve efficiency and lower completion costs, pressure-activated toe sleeves (PATS) have rapidly replaced the TCP CT run to create the initial fluid flow path. The PATS is run as part of the completion casing and cemented in place. Internal casing pressure is then applied to open the PATS and create the flow path. However, to accomplish a casing pressure test, the first generation PATS design must have the activation pressure set higher than the testing pressure. The casing test pressure must then be exceeded to open the PATS which is not ideal operationally for a variety of reasons. This paper reviews a case study where a new, second generation PATS was used in an Eagle Ford shale well to allow a true casing pressure test and provide the initial flow path. The paper discusses the subject well, design, and operation of second generation PATS technology, and presents the results of the application. The positive economic impacts are also reviewed. The paper draws conclusions based on the results from the subject well, operation of the new PATS tool, and the economic impact experienced.
Periodic broadcast and patching services (2001)

Multimedia streaming applications can consume a significant amount of server and network resources. Periodic broadcast and patching are two approaches that use multicast transmission and client buffering in innovative ways to reduce server and network load, while at the same time allowing asynchronous access to multimedia steams by a large number of clients. Current research in this area has focussed primarily on the algorithmic aspects of these approaches, with evaluation performed via analysis or simulation. In this paper, we describe the design and implementation of a flexible streaming video server and client testbed that implements both periodic broadcast and patching, and explore the issues that arise when implementing these algorithms. We present measurements detailing the overheads associated with the various server components (signaling, transmission schedule computation, data retrieval and transmission), the interactions between the various components of the architecture, and the overall end-to-end performance. We also discuss the importance of an appropriate server video segment caching policy. We conclude with a discussion of the insights gained from our implementation and experimental evaluation.
Future Vehicular Recuperator Technology Projections (1994)

The Department of Defense and NASA have funded a major gas turbine development program, Integrated High Performance Turbine Engine Technology (IHPTET), to double the power density and fuel economy of gas turbines by the turn of the century. Seven major US gas turbine developers participated in this program. While the focus of IHPTET activity has been aircraft propulsion, the same underlying technology can be applied to water craft and terrestrial vehicle propulsion applications, such as the future main battle tank. For these applications, the gas turbines must be equipped with recuperators. Currently, there is no technology roadmap or set of goals to guide industry and government in the development of a next generation recuperator for such applications.
Evaluation of Biosafety, Antiobesity, and Endothelial Cells Proliferation Potential of Basil Seed Extract Loaded Organic Solid Lipid Nanoparticle (2021)

The present study aimed to synthesize solid lipid nanoparticles to enhance liposome-assisted intracellular uptake of basil seed active components in adipocytes and vascular smooth muscle cells to attain increased bioavailability. To obtain solid lipid nanoparticle (SLNp), the water phase containing basil seed extract (BSE) was encapsulated with lipid matrix containing chia seed phospholipids using homogenization and cold ultra-sonication method. The physicochemical characterization of BSE loaded solid lipid nanoparticles (BSE-SLNp) has been analyzed using Zetasizer, FT-IR, and TEM. The BSE-SLNp showed an average diameter of 20-110 nm on the day of preparation and it remains the same after 60 days of storage. The cytotoxicity assay confirmed that the BSE-SLNp did not produce toxicity in hMSCs, preadipocytes, or human umbilical vein endothelial cells (HUVECs) until the tested higher dose up to 64 μg/ml. During effective dose determination, 4 μg/ml of BSE-SLNp confirmed non-toxic and enhanced metabolic function in hMSCs, preadipocytes, and HUVECs. Biosafety assay confirmed normal nuclear morphology in PI staining and high mitochondrial membrane potential in JC-1 assay within 48 h in hMSCs. The maturing adipocyte treated with 4 μg/ml of BSE-SLNp significantly increased the mitochondrial efficiency and fatty acid beta-oxidation (PPARγC1α, UCP-1, and PRDM-16) related gene expression levels. Oxidative stress induced HUVECs treated with 4 μg/ml of BSE-SLNp potentially enhanced antioxidant capacity, cell growth, and microtubule development within 48 h H<sub>2</sub>O<sub>2</sub> induced oxidative stressed HUVECs have shown 39.8% viable cells, but treatment with BSE-SLNp has shown 99% of viable cells within 48 h confirmed by Annexin-V assay. In addition, mitochondrial membrane potential (Δψ<sub>m</sub>) increased to 89.4% confirmed by JC-1 assay. The observed DNA integrity, cell viability was confirmed by increased antioxidant and tumor suppressor-related gene expression levels. VEGF expression has been significantly increased and pro-inflammation-related mRNA levels were decreased in BSE-SLNp treated cells. In conclusion, enhanced adipocyte fatty acid oxidation is directly associated with decreased adipocytokine secretion which arrests obesity-associated comorbidities. In addition, suppressing vascular cell oxidative stress and metabolic inflammation supports vascular cell proliferation and arrests ageing-related vascular diseases.
Data from CD24 Expression Causes the Acquisition of Multiple Cellular Properties Associated with Tumor Growth and Metastasis (2023)

&lt;div&gt;Abstract&lt;p&gt;The glycosylphosphatidylinositol-anchored membrane protein CD24 functions as an adhesion molecule for P-selectin and L1 and plays a role in B-cell development and neurogenesis. Over the last few years, a large body of literature has also implicated CD24 expression in tumorigenesis and progression. Here, we show that ectopic CD24 expression can be sufficient to promote tumor metastasis in experimental animals. By developing a doxycycline-inducible system for the expression of CD24 in breast cancer cells, we have also analyzed the cellular properties that CD24 expression influences. We found that CD24 expression increased tumor cell proliferation. Furthermore, in addition to promoting binding to P-selectin, CD24 expression also indirectly stimulated cell adhesion to fibronectin, collagens I and IV, and laminin through the activation of α&lt;sub&gt;3&lt;/sub&gt;β&lt;sub&gt;1&lt;/sub&gt; and α&lt;sub&gt;4&lt;/sub&gt;β&lt;sub&gt;1&lt;/sub&gt; integrin activity. Moreover, CD24 expression supported rapid cell spreading and strongly induced cell motility and invasion. CD24-induced proliferation and motility were integrin independent. Together, these observations implicate CD24 in the regulation of multiple cell properties of direct relevance to tumor growth and metastasis.&lt;/p&gt;&lt;/div&gt;
Workshop W2 (2006)

The main objective of the third workshop on Multi-User and Ubiquitous User Interfaces (MU3I 2006) is to bring people with relevant backgrounds (e.g. interface design, CSCW, ubiquitous computing) together to discuss two key questions in this field: How can we build interfaces, which span multiple devices so that the user knows that they can be used to control a specific application? How can we build interfaces for public displays? Therefore, the main outcome of the workshop is expected to consists of further insights into those problems, potential solutions and a research agenda to investigate these further.
Vascular Wall Maturation and Prolonged Angiogenic Effect by Endothelial-Specific Platelet-Derived Growth Factor Expression (2006)

Systemic gene therapy with the angiogenic factors VEGF and PDGF-B under angiogenic- endothelial cell-specific regulation was effective in inducing functionally and morphologically mature vasculature.
An electro-optic modulator using a multi-channel directional coupler with a poled electro-optic polymer (2010)

We describe an electro-optic polymer modulator for 1310 nm using a multi-channel directional coupler structure, and examine various electrode structures.
Reducing segmentation failures in cardiac MRI via late feature fusion and GAN-based augmentation (2023)

Cardiac magnetic resonance (CMR) image segmentation is an integral step in the analysis of cardiac function and diagnosis of heart related diseases. While recent deep learning-based approaches in automatic segmentation have shown great promise to alleviate the need for manual segmentation, most of these are not applicable to realistic clinical scenarios. This is largely due to training on mainly homogeneous datasets, without variation in acquisition, which typically occurs in multi-vendor and multi-site settings, as well as pathological data. Such approaches frequently exhibit a degradation in prediction performance, particularly on outlier cases commonly associated with difficult pathologies, artifacts and extensive changes in tissue shape and appearance. In this work, we present a model aimed at segmenting all three cardiac structures in a multi-center, multi-disease and multi-view scenario. We propose a pipeline, addressing different challenges with segmentation of such heterogeneous data, consisting of heart region detection, augmentation through image synthesis and a late-fusion segmentation approach. Extensive experiments and analysis demonstrate the ability of the proposed approach to tackle the presence of outlier cases during both training and testing, allowing for better adaptation to unseen and difficult examples. Overall, we show that the effective reduction of segmentation failures on outlier cases has a positive impact on not only the average segmentation performance, but also on the estimation of clinical parameters, leading to a better consistency in derived metrics.
Regulation of cell-mediated immunity in cryptococcosis. III. Characterization of second-order T suppressor cells (Ts2). (1985)

Frequently, patients with systemic cryptococcosis have depressed or absent in vivo or in vitro cell-mediated immune responses to cryptococcal antigen. In addition, these patients have relatively high levels of circulating cryptococcal antigen, which is generally considered indicative of a poor prognosis. Because acquired cell-mediated immunity is an important host defense mechanism in cryptococcosis, we have been studying the effects of cryptococcal antigen on such responses. Using a murine model, we have demonstrated that cryptococcal antigen given i.v. to CBA/J mice, to simulate antigen levels found in patients, can trigger the production of a series of suppressor cells that specifically inhibit anticryptococcal cell-mediated immune responses. Briefly, cryptococcal antigen induces afferent suppressor and/or suppressor inducer (Ts1) cells in the lymph nodes of mice, and the Ts1 cells, or a soluble factor derived therefrom (TsF1), stimulate the production of second-order or efferent suppressor (Ts2) cells. This report provides data that demonstrate that the Ts2 cells were induced in spleens from cyclophosphamide (Cy)-resistant precursors in response to cryptococcal Ts1 cells or TsF1 and that a proliferative process sensitive to Cy was not required for Ts2 induction. The Ts2 cells were detectable 6 days after Ts1 injection, were specific in suppressing the cryptococcal delayed-type hypersensitivity (DTH) response, were T cells with an Lyt-1-,2+,Ia+ (I-J+) phenotype, were effective only on the efferent limb of the cryptococcal DTH response, and mediated their activity via a soluble factor (TsF2). Thus far, the suppressive pathway induced by cryptococcal antigen has characteristics more like those of the suppressor circuits described for the DTH responses to the haptens azobenzenearsonate and 4-hydroxy-3-nitrophenyl acetyl than those of the modulating circuits induced by other antigens. We postulate that a suppressive circuit similar to the one we have defined in the mouse model is operating to suppress the in vivo and in vitro cell-mediated immune responses in cryptococcosis patients who have significant amounts of circulating cryptococcal antigen.
<title>Horizontal line of sight turbulence over near-ground paths and implications for adaptive optics corrections in laser communications</title> (1997)

Atmospheric turbulence over long horizontal paths perturbs phase and also can cause severe intensity scintillation in the pupil of an optical communications receiver. This limits the bit error rate over which intensity based modulation schemes can operate. To quantifi the extent ofthe problem, we built a high speed and high resolution wavefront sensor capable of measuring both the amplitude and phase over a horizontal turbulent path. We present resulting measurements of the probability distributions ofboth amplitude and phase as well as Zernike polynomial decomposition ofthe temporal power spectra of phase fluctuations. These results are compared to existing turbulence models, and are used to determine requirements for a wavefront correction scheme using adaptive optics.