gebhart/patrepeval huggingface dataset:
10 Gb/s Integrated Tunable Hybrid III-V/Si Laser and Silicon Mach-Zehnder Modulator (2012)

We demonstrate a tunable transmitter, integrating a hybrid III-V/Si laser fabricated by wafer bonding and a silicon Mach-Zehnder modulator. The integrated transmitter exhibits 9 nm wavelength tunability by heating an intra-cavity ring resonator, high extinction ratio from 6 to 10 dB, and excellent bit-error-rate performance at 10 Gb/s.
Parameter Domain Loudness Estimation in Parametric Audio Object Coding (2018)

Parametric audio object coding employs principles of informed source separation for obtaining object reconstructions from the mixture signal used in the transport enabling flexible output signal rendering into output scenes unknown at the encoder. Information of the object level in the rendered output is important for loudness and dynamic range control applications, e.g., in broadcast. This paper proposes a method for estimating the object level in an arbitrary output scene based on the downmix signal level that is then projected through the combined un-mixing and rendering matrix. This avoids explicit reconstruction of the objects only for the level estimation offering computational complexity savings. In the evaluations, the proposed method shows a high estimation accuracy with a root-mean squared error of 0.26 LUFS (loudness units relative to full scale) compared to 3.7 L UFS of the baseline with object reconstructions.
Study on STI planarization process using fixed abrasive tool (1st Report) (2004)

Novel chemical mechanical polishing (CMP) process using a fixed abrasive tool (FX-tool), which is a kind of grindstone, was developed for dielectric planarization. In order to obtain flat surface for 45-nm-node of semiconductor generation, two points that are adopting stiff polishing pad/tool and reducing concentration of free-abrasives become critical issues. Newly developed FX-tool has more than ten times higher Young's modulus than that of a conventional CMP pad, and simultaneously, concentration of free abrasives on its surface can be controlled by polishing time. In experiments using several test-wafers, less than 30nm of dishing was obtained up to 3mm-length-pattern. Additionally, polyacrylic ammonium (PAA) effectively affects to increase degree of selectivity between oxide and nitride for shallow trench isolation (STI) process. The selectivity of 41 was obtained at 3 vol.% concentration of PAA. STI test wafers were successfully polished without any additional processes such as etching back.
Abstract 2128: Autocrine fibronectin inhibits breast cancer metastasis (2018)

Abstract The processes of the epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are strongly linked to breast cancer metastasis via their ability to generate cells of increased invasive capacity and enhanced tumor-initiating phenotypes. Numerous growth factors, cytokines and chemotherapies present in the tumor microenvironment are capable of inducing EMT, but the role of extracellular matrix (ECM) components in this process remains less well understood. Analysis of the METABRIC dataset strongly linked high-level FN expression to decreased patient survival. However, in vitro analysis of the MCF-10A progression series indicated that autocrine FN expression was associated with nonmetastatic cells. Therefore, we utilized differential bioluminescent imaging to track the metastasis of these isogenic epithelial and mesenchymal cells within heterogeneous primary tumors. Using this approach, we demonstrate that tumor cells expressing autocrine FN display a constitutively mesenchymal phenotype and are incapable of completing the metastatic process, even when grown within a tumor containing epithelial tumor cells. Importantly, depletion of FN allows tumor cells to exit their mesenchymal state, regain epithelial characteristics and initiate tumor growth in a metastatic microenvironment. Using a tessellated three-dimensional polymer scaffolding, we show that depletion of FN or pharmacologic inhibition of focal adhesion kinase prevents mesenchymal tumor cells from producing structural fibrils and thus supporting the growth and migration of metastatic-competent epithelial tumor cells. Finally, dynamic FN coating of this 3D growth scaffold resulted in formation of a functionalized fibrillar FN network that was sufficient to induce transient EMT events as metastatic cells migrated along FN fibrils. Taken together, our data indicate that autocrine expression of FN by tumor cells supports a stable mesenchymal phenotype limiting their metastatic potential. Instead, this tumor cell-derived production of fibrillar FN acts in a paracrine fashion to support transient EMT events in metastatic competent cells within a heterogeneous tumor microenvironment. Citation Format: Aparna Shinde, Ammara Abdullah, Luis Solorio, Michael Wendt. Autocrine fibronectin inhibits breast cancer metastasis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2128.
Discrete-Time Reduced-Complexity Youla Parameterization for Dual-Input Single-Output Systems (2015)

A controller design is presented for directly shaping the sensitivity function in the feedback control of dual-input single-output (DISO) systems. We provide special forms of discrete-time Youla-Kucera (YK) parameterization to obtain stabilizing controllers for DISO systems, and discuss concepts to achieve a reduced-complexity formulation. The proposed YK parameterization is based on an inverse of the loop transfer function, which gives benefits such as clearer design intuition and reduced complexity in construction. The algorithm is verified by simulations and experiments on hard disk drive systems, with application to wideband vibration and harmonic disturbance rejections.
Microsatellites and SNPs linkage analysis in a Sardinian genetic isolate confirms several essential hypertension loci previously identified in different populations (2009)

Our search for major susceptibility EH genetic factors evidences that EH in the genetic isolate of Talana is due to the contribution of several genes contained in loci identified and replicated by earlier findings in different human populations.
Dexmedetomidine Partially Attenuates the Sympathetically Mediated Systemic and Coronary Hemodynamic Effects of Cocaine (1995)

Departments of Anesthesiology, Pharmacology, and Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, and the Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin
Precision extruding deposition (PED) fabrication of polycaprolactone (PCL) scaffolds for bone tissue engineering (2009)

Bone tissue engineering is an emerging field providing viable substitutes for bone regeneration. Recent advances have allowed scientists and engineers to develop scaffolds for guided bone growth. However, success requires scaffolds to have specific macroscopic geometries and internal architectures conducive to biological and biophysical functions. Freeform fabrication provides an effective process tool to manufacture three-dimensional porous scaffolds with complex shapes and designed properties. A novel precision extruding deposition (PED) technique was developed to fabricate polycaprolactone (PCL) scaffolds. It was possible to manufacture scaffolds with a controlled pore size of 350 microm with designed structural orientations using this method. The scaffold morphology, internal micro-architecture and mechanical properties were evaluated using scanning electron microscopy (SEM), micro-computed tomography (micro-CT) and mechanical testing, respectively. An in vitro cell-scaffold interaction study was carried out using primary fetal bovine osteoblasts. Specifically, the cell proliferation and differentiation was evaluated by Alamar Blue assay for cell metabolic activity, alkaline phosphatase activity and osteoblast production of calcium. An in vivo study was performed on nude mice to determine the capability of osteoblast-seeded PCL to induce osteogenesis. Each scaffold was implanted subcutaneously in nude mice and, following sacrifice, was explanted at one of a series of time intervals. The explants were then evaluated histologically for possible areas of osseointegration. Microscopy and radiological examination showed multiple areas of osseous ingrowth suggesting that the osteoblast-seeded PCL scaffolds evoke osteogenesis in vivo. These studies demonstrated the viability of the PED process to fabricate PCL scaffolds having the necessary mechanical properties, structural integrity, and controlled pore size and interconnectivity desired for bone tissue engineering.
The use of imaging for electrophysiological and devices procedures: a report from the first European Heart Rhythm Association Policy Conference, jointly organized with the European Association of Cardiovascular Imaging (EACVI), the Council of Cardiovascular Imaging and the European Society of Cardiac Radiology (2013)

Implantations of cardiac devices therapies and ablation procedures frequently depend on accurate and reliable imaging modalities for pre-procedural assessments, intra-procedural guidance, detection of complications, and the follow-up of patients. An understanding of echocardiography, cardiovascular magnetic resonance imaging, nuclear cardiology, X-ray computed tomography, positron emission tomography, and vascular ultrasound is indispensable for cardiologists, electrophysiologists as well as radiologists, and it is currently recommended that physicians should be trained in several imaging modalities. There are, however, no current guidelines or recommendations by electrophysiologists, cardiac imaging specialists, and radiologists, on the appropriate use of cardiovascular imaging for selected patient indications, which needs to be addressed. A Policy Conference on the use of imaging in electrophysiology and device management, with representatives from different expert areas of radiology and electrophysiology and commercial developers of imaging and device technologies, was therefore jointly organized by European Heart Rhythm Association (EHRA), the Council of Cardiovascular Imaging and the European Society of Cardiac Radiology (ESCR). The objectives were to assess the state of the level of evidence and a first step towards a consensus document for currently employed imaging techniques to guide future clinical use, to elucidate the issue of reimbursement structures and health economy, and finally to define the need for appropriate educational programmes to ensure clinical competence for electrophysiologists, imaging specialists, and radiologists.
Impact of Ethylene on Efficiency and Stereocontrol in Olefin Metathesis: When to Add It, When to Remove It, and When to Avoid It (2020)

Ethylene is the byproduct of olefin metathesis reactions that involve one or more terminal alkenes. Its volatility is one reason why many cross-metathesis or ring-closing metathesis processes, which are reversible transformations, are efficient. However, because ethylene can be converted to a methylidene complex, which is a highly reactive but relatively unstable species, its concentration can impact olefin metathesis in other ways. In some cases, introducing excess ethylene can increase reaction rate owing to faster catalyst initiation. Ethylene and a derived methylidene complex can also advantageously inhibit substrate or product homocoupling, and/or divert a less selective pathway. In other instances, a methylidene's low stability and high activity may lead to erosion of efficiency and/or kinetic selectivity, making it preferable that ethylene is removed while being generated. If methylidene decomposition is so fast that there is little or no product formation, it is best that ethylene and methylidene complex formation is avoided altogether. This is accomplished by the use of di- or trisubstituted alkenes in stereoretentive processes, which includes adopting methylene capping strategy. Here, we analyze the different scenarios through which ethylene and the involvement of methylidene complexes can be manipulated and managed so that an olefin metathesis reaction may occur more efficiently and/or more stereoselectively.
Informed data-hiding with partial side information at the decoder (2009)

In this paper, we extend a traditional robust data-hiding set-up with host state at the encoder to a case when a partial side information about host statistics is alsoavailable at the decoder. We demonstrate that the knowledge of host statistics at the decoder can relax the critical requirements of random binning-based methodsconcerning attack channel statistics at the encoder. We also analyze performance improvement of some known data-hiding methods showing that they are particular cases of the generalized set-up. Finally, we consider some related open research issues and future possible extensions.
An Overview on Ischemic Colitis Diagnostic & Management Approach (2021)

Ischemic colitis (IC) is the most frequent form of intestinal ischemia, affecting mostly older people with a reported incidence of 16 cases per 100,000 person-years. It is caused by a sudden cut in the blood flow to the colon that compromises its perfusion and functionality. It is transient in most cases and resolves without sequelae, whereas some patients develop colonic necrosis and gangrene that can be life-threatening. Therefore, a high index of suspicion, prompt diagnosis, and treatment are
Highly conserved modified nucleosides influence Mg2+-dependent tRNA folding (2002)

Transfer RNA structure involves complex folding interactions of the TPsiC domain with the D domain. However, the role of the highly conserved nucleoside modifications in the TPsiC domain, rT54, Psi55 and m5C49, in tertiary folding is not understood. To determine whether these modified nucleosides have a role in tRNA folding, the association of variously modified yeast tRNA(Phe) T-half molecules (nucleosides 40-72) with the corresponding unmodified D-half molecule (nucleosides 1-30) was detected and quantified using a native polyacrylamide gel mobility shift assay. Mg2+ was required for formation and maintenance of all complexes. The modified T-half folding interactions with the D-half resulted in K(d)s (rT54 = 6 +/- 2, m5C49 = 11 +/- 2, Psi55 = 14 +/- 5, and rT54,Psi55 = 11 +/- 3 microM) significantly lower than that of the unmodified T-half (40 +/- 10 microM). However, the global folds of the unmodified and modified complexes were comparable to each other and to that of an unmodified yeast tRNA(Phe) and native yeast tRNA(Phe), as determined by lead cleavage patterns at U17 and nucleoside substitutions disrupting the Levitt base pair. Thus, conserved modifications of tRNA's TPsiC domain enhanced the affinity between the two half-molecules without altering the global conformation indicating an enhanced stability to the complex and/or an altered folding pathway.
Deriving compact test suites for telecommunication software using distance metrics (2008)

This paper proposes a string edit distance based test selection method to generate compact test sets for telecommunications software. Following the results of previous research, a trace in a test set is considered to be redundant if its edit distance from others is less than a given parameter. The algorithm first determines the minimum cardinality of the target test set in accordance with the provided parameter, then it selects the test set with the highest sum of internal edit distances. The selection problem is reduced to an assignment problem in bipartite graphs.
Bixin stimulates immune response in cats (2007)

Studies on its immune modulatory action is lacking. Female domestic cats (3 yr old) were fed daily for 16 wk with 0, 1, 5 or 10 mg bixin (n = 14/group). Blood was sampled on wk 0, 6, 12 and 16. All cats were then vaccinated with an attenuated polyvalent vaccine on wk 12 and 14. Skin hypersensitivity response (DTH) to saline, concanavalin A, the vaccine, and histamine was assessed on wk 12 and 16. Lymphoproliferation, leukocyte subpopulations, NK cell cytotoxicity and Ig production were assessed. Acid glycoprotein concentrations and DNA damage were determined in plasma. Cats fed 1 mg bixin showed enhanced NK cytotoxicity and DTH response to vaccine, and suppressed acid glycoprotein concentration and DNA damage. Those fed 5 mg bixin generally showed the highest immune stimulatory and antioxidative action. In this treatment, bixin enhanced lymphoblastogenic response, populations of T helper and T cytotoxic cells, NK cytotoxicity and IgG production; bixin also inhibited DNA damage. At 10 mg, bixin stimulated DTH response to con A, percent of total T and T cytotoxic cells, and IgG production; however, it inhibited mitogen‐induced lymphocyte proliferation. All doses of bixin reduced skin response to histamine and CD18 subpopulations. Therefore, dietary bixin, especially at the 5 mg dose, heightened cell‐mediated and humoral immune response, and inhibited DNA oxidative damage and inflammation in cats.
A TR-induced algorithm for hot spots elimination through CT-scan HIFU simulations (2011)

Although nowadays widely spread for imaging and treatments uses, HIFU techniques are still limited by the distortion of the wavefront due to refraction and reflection on the inhomogeneous media inside the human body. CT‐scan Time Reversal (TR) procedure has risen as a promising candidate for focus control. A finite difference time domain parallelized code is used to provide simulations of TR‐enhanced propagation through elements of the human body and implement a simple algorithm to address the issue of grating lobes, i.e secondary peaks of pressure due to natural diffraction by phased arrays and enhanced by medium heterogeneity. Using an iterative, progressive process combining secondary sound sources and independent signal summation, the primary peak is strengthened while secondary peaks are increasingly obliterated. This method supports the feasibility of precise modification and enhancement of the pressure profile in the targeted area through Time Reversal based solutions.
A Brief Treatment of Generalized Functions for Use in Teaching the Laplace Transform (2006)

A simple yet rigorous treatment of generalized functions is presented, which avoids the complications of a full-fledged theory while covering the situations that occur in engineering applications. This treatment of functions with singularities is both sufficiently concrete to be quickly understood and sufficiently general to be widely useful. Using this treatment as a foundation, an approach to the unilateral Laplace transform that accepts the presence of impulses and arbitrary initial conditions is easily presented and explained
Nasotracheal Suctioning (1996)

Hilling, Lana RCP, CRTT; Bakow, Eric RRT; Fink, James MS, RCP, RRT; Kelly, Chris BS, RRT; Sobush, Dennis MA, PT; Southorn, Peter A. MD Author Information
Dipole Approximation to Predict the Resonances of Dimers Composed of Dielectric Resonators for Directional Emission (2017)

Abstract In this paper we develop a fully retarded, dipole approximation model to estimate the effective polarizabilities of a dimer made of dielectric resonators. They are computed from the polarizabilities of the two resonators composing the dimer. We analyze the situation of full cubes as well as split cubes, which have been shown to exhibit overlapping electric and magnetic resonances. We compare the effective dimer polarizabilities to ones retrieved via full‐wave simulations as well as ones computed via a quasi‐static, dipole approximation. We observe good agreement between the fully retarded solution and the full‐wave results, whereas the quasi‐static approximation is less accurate for the problem at hand. The developed model can be used to predict the electric and magnetic resonances of a dimer under parallel or orthogonal (to the dimer axis) excitation. This is particularly helpful when interested in locating frequencies at which the dimer will emit directional radiation.
BINGS: A Backpack Imaging Neutron and Gamma Spectrometer for Emergency Responders. (2011)

Abstract not provided.
State-of-the-art Tools for Computational Site of Metabolism Predictions: Comparative Analysis, Mechanistical Insights, and Future Applications (2007)

In drug design, it is crucial to have reliable information on how a chemical entity behaves in the presence of metabolizing enzymes. This requires substantial experimental efforts. Consequently, being able to predict the likely site/s of metabolism in any compound, synthesized or virtual, would be highly beneficial and time efficient. In this work, six different methodologies for predictions of the site of metabolism (SOM) have been compared and validated using structurally diverse data sets of drug-like molecules with well-established metabolic pattern in CYP3A4, CYP2C9, or both. Three of the methods predict the SOM based on the ligand's chemical structure, two additional methods use structural information of the enzymes, and the sixth method combines structure and ligand similarity and reactivity. The SOM is correctly predicted in 50 to 90% of the cases, depending on method and enzyme, which is an encouraging rate. We also discuss the underlying mechanisms of cytochrome P450 metabolism in the light of the results from this comparison.
ChemInform Abstract: Transition Metal Catalyzed Intramolecular (4 + 2) Cycloadditions: A Novel Method for the Assembly of Nitrogen Heterocycles and Its Application to Yohimban Alkaloid Synthesis. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription. (1992)

The major nuclear ribonucleoproteins (RNPs) involved in pre-mRNA processing are classified in broad terms either as small nuclear RNPs (snRNPs), which are major participants in the splicing reaction, or heterogeneous nuclear RNPs (hnRNPs), which traditionally have been thought to function in general pre-mRNA packaging. We obtained antibodies that recognize these two classes of RNP in Drosophila melanogaster. Using a sequential immunostaining technique to compare directly the distribution of these RNPs on Drosophila polytene chromosomes, we found that the two patterns were very similar qualitatively but not quantitatively, arguing for the independent deposition of the two RNP types and supporting a role for hnRNP proteins, but not snRNPs, in general transcript packaging.