gebhart/patrepeval huggingface dataset:
Energy-efficient Blood Pressure Monitoring based on Single-site Photoplethysmogram on Wearable Devices (2021)

The paper proposes accurate Blood Pressure Monitoring (BPM) based on a single-site Photoplethysmographic (PPG) sensor and provides an energy-efficient solution on edge cuffless wearable devices. Continuous PPG signal preprocessed and used as input of the Artificial Neural Network (ANN), and outputs systolic BP (SBP), diastolic BP (DBP), and mean arterial BP (MAP) values for each heartbeat. The improvement of the BPM accuracy is obtained by removing outliers in the preprocessing step and the whole-based inputs compared to parameter-based inputs extracted from the PPG signal. Performance obtained is 3.42 ± 5.42 mmHg (MAE ± RMSD) for SBP, 1.92 ± 3.29 mmHg for DBP, and 2.21 ± 3.50 mmHg for MAP which is competitive compared to other studies. This is the first BPM solution with edge computing artificial intelligence as we have learned so far. Evaluation experiments on real hardware show that the solution takes 42.2 ms, 18.2 KB RAM, and 2.1 mJ average energy per reading.
Rapidly tunable optical add~drop multiplexer (OADM) using a static-strain-induced grating in LiNbO/sub 3/ (2003)

A rapidly tunable, polarization-independent, low-loss optical add-drop multiplexer (OADM) for the 1550-nm wavelength regime is reported. The four-port device consists of two input waveguides, a polarization beam splitter (PBS), two polarization conversion/electrooptic tuning waveguide sections, a second PBS and two output waveguides. The waveguides, which are single mode for both TE and TM polarizations, are fabricated on a LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> substrate by Ti diffusion. Spectral selection is based on phase-matched polarization conversion due to shear strain induced by a dielectric grating overlay film. An applied voltage tunes the device by changing the waveguide birefringence and hence the optical wavelength at which most efficient polarization conversion occurs. Tuning of 0.1 nm/V with a maximum range of 24 nm has been obtained. A tuning speed of 50 ns, corresponding to a rate of 0.128 nm/ns, has been achieved. Channel isolation is better than 24 dB. Fiber-to-fiber insertion loss <5.4 dB has been obtained and polarization independent loss (PDL) of 0.24 dB for both drop and through ports have been realized over the tuning range. Thermal tuning has also been demonstrated.
Targeted Fluorogenic Cyanine Carbamates Enable In Vivo Analysis of Antibody-Drug Conjugate Linker Chemistry (2021)

Antibody-drug conjugates (ADCs) are a rapidly emerging therapeutic platform. The chemical linker between the antibody and the drug payload plays an essential role in the efficacy and tolerability of these agents. New methods that quantitively assess cleavage efficiency in complex tissue settings could provide valuable insights into the ADC design process. Here we report the development of a near-infrared (NIR) optical imaging approach that measures the site and extent of linker cleavage in mouse models. This approach is enabled by a superior variant of our recently devised cyanine carbamate (CyBam) platform. We identify a novel tertiary amine-containing norcyanine, the product of CyBam cleavage, that exhibits dramatically in-creased cellular signal due to improved cellular permeability and lysosomal accumulation. The resulting cyanine lysosome-targeting carbamates (CyLBams) are ~50X brighter in cells, and we find this strategy is essential for high-contrast in vivo targeted imaging. Finally, we compare a panel of several common ADC linkers across two antibodies and tumor models. These studies indicate that cathepsin-cleavable linkers provide dramatically higher tumor activation relative to hindered or non-hindered disulfides – an observation that is only apparent with in vivo imaging. This strategy enables quantitative com-parisons of cleavable linker chemistries in complex tissue settings with implications across the drug delivery landscape.
Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance (2002)

The Th1 cytokines IL-2 and IFN-γ, which inhibit T cell proliferation and promote activation induced cell death, may be required to diminish alloreactive T cell numbers and to foster tolerance across full allogeneic barriers. However, we hypothesized that these cytokines might be dispensable when the alloreactive T cell clone size is relatively small, as is seen in recipients of minor-mismatched grafts. We show that alloreactive T cell clone size of C57BL/6 mice against multiple minor-mismatched 129X1/sv mice was ∼4–9-fold smaller than that against MHC-mismatched BALB/c mice. In the MHC-mismatched combination, CD28-B7 blockade by CTLA4Ig induced long-term graft survival in wild-type recipients, but this treatment was ineffective in IFNγ–/– or IL-2–/– recipients. In contrast, in the minor-mismatched combination, CTLA4Ig induced long-term allograft survival in wild-type, IFNγ–/–, and IL-2–/– recipients. Bcl-xL transgenic animals, which are defective in "passive" T cell death, are likewise sensitive to the effects of CTLA4Ig only in the setting of the minor-mismatch grafts. Therefore, the alloreactive T cell clone size is an important determinant affecting the need for Th1 cytokines and T cell death in tolerance induction. These data have implications for the design of tolerance strategies in transplant recipients with varying degrees of MHC mismatching.
Defect printability in CPL mask technology (2004)

Each generation of semiconductor device technology drive new and interesting resolution enhancement technology (RET’s). The race to smaller and smaller geometry’s has forced device manufacturers to k1’s approaching 0.40. The authors have been investigating the use of Chromeless phase-shifting masks (CPL) exposed with ArF, high numerical aperture (NA), and off-axis illumination (OAI) has been shown to produce production worthy sub-100nm resist patterns with acceptable overlapped process window across feature pitch. These new reticle technologies have many issues that are similar to simple binary masks. The authors have investigated the printability of defects in CPL mask technology. Programmed defects of various sizes and types have been simulated and printed for sub 100nm imaging. High resolution scanning electron microscopy has been used to characterize these defects and develop an understanding of size and type that prints. In this paper the authors will focus on image line end shortening and the impact of through dose and focus performance for very high NA ArF imaging. The authors have built a number of test structures that require superior 2D control for SRAM gate structures. Various types of line ends have been evaluated for either straight CPL mask or hybrid type builds.
Lattice and magnetic dynamics in the YVO3 Mott insulator studied by neutron scattering and first-principles calculations (2022)

The Mott insulator ${\mathrm{YVO}}_{3}$ with ${T}_{N}=118\phantom{\rule{0.16em}{0ex}}\mathrm{K}$ is revisited to explore the role of spin, lattice, and orbital correlations across the multiple structural and magnetic transitions observed as a function of temperature. Upon cooling, the crystal structure changes from orthorhombic to monoclinic at 200 K, and back to orthorhombic at 77 K, followed by magnetic transitions. From the paramagnetic high-temperature phase, C-type magnetic ordering is first observed at 118 K, followed by a G-type spin re-orientation transition at 77 K. The dynamics of the transitions were investigated via inelastic neutron scattering and first-principles calculations. An overall good agreement between the neutron data and calculated spectra was observed. From the magnon density of states, the magnetic exchange constants were deduced to be ${J}_{ab}={J}_{c}=\ensuremath{-}5.8\phantom{\rule{0.16em}{0ex}}\mathrm{meV}$ in the G-type spin phase, and ${J}_{ab}=\ensuremath{-}3.8\phantom{\rule{0.16em}{0ex}}\mathrm{meV}$, ${J}_{c}=7.6\phantom{\rule{0.16em}{0ex}}\mathrm{meV}$ at 80 K and ${J}_{ab}=\ensuremath{-}3.0\phantom{\rule{0.16em}{0ex}}\mathrm{meV}$, ${J}_{c}=6.0\phantom{\rule{0.16em}{0ex}}\mathrm{meV}$ at 100 K in the C-type spin phase. Paramagnetic scattering was observed in the spin ordered phases, well below the C-type magnetic transition temperature, which continuously increased above the transition. Fluctuations in the temperature dependence of the phonon density of states were observed between 50 and 80 K as well, coinciding with the G-type to C-type transition. These fluctuations are attributed to optical oxygen modes above 40 meV, from first-principles calculations. In contrast, little change in the phonon spectra is observed across ${T}_{N}$.
Gradient Interphase between Reactive Epoxy and Glassy Thermoplastic from Dissolution Process, Reaction Kinetics, and Phase Separation Thermodynamics (2001)

Planar interfaces have been prepared by assembling high-Tg thermoplastics such as poly(phenylene ether) (PPE) or poly(ether imide) (PEI) and epoxy−amine networks at different conversions of the epoxy groups, Xe, followed by a complete curing. Direct evidence of the structure of the interfacial regions was made by means of electron microscopies, SEM and TEM, and atomic force microscopy, after a complete curing of the epoxy−amine. The morphologies of the interfaces are explained from the competition between the dissolution process of a thermoplastic by nonreactive solvent and the thermodynamics and the kinetics of reactive epoxy−amine/thermoplastic system. If the phase diagram indicates that the epoxy−amine/thermoplastic system is nonmiscible, the interface remains very thin (<20 nm). In the opposite, a gap range of miscibility controlled by the polymerization rate allows a diffusion of the comonomers into the thermoplastic layer and its further dissolution. As a consequence, 100−400 μm thick interphases can be generated. A gradient morphology results from the gradient composition at phase separation. The gradient composition or concentration profile is shown to depend on the type of dissolution process that is mainly determined by the competition between the thermodynamic osmotic pressure and the swelling resistance of the thermoplastic.
Laser‐scribed Graphene Electrodes as an Electrochemical Immunosensing Platform for Cancer Biomarker ‘eIF3d’ (2020)

Abstract eIF3d is a protein biomarker which has a potential for the diagnosis of various cancers. Herein, a bio‐platform was constructed for eIF3d sensing by using LSG and surface functionalization with anti eIF3d antibody via EDC/NHS chemistry. Following the surface modifications, XPS and several electrochemical methods were used. Difference in the signals were related to biomarker amounts between 75–500 ng/mL. LOD was calculated as 50.4 ng/mL. Selectivity of biosensor was tested by using of various interference molecules. EIF3d was also successfully detected in synthetic biological samples. Thus, to the best of our knowledge, this study is one of the rare studies on use of LSGs in immunosensor studies.
Molecular markers of sperm quality (2019)

Light microscopic semen evaluation provides useful information about a given sperm sample, but due to its subjective nature has limited prognostic value for the reproductive performance of males or the outcome of assisted fertilization. Cryptic sperm abnormalities (occurring at the molecular level) are not easily detectable by light microscopy, but can be revealed by an array of biomarkers. The latter include fluorescent markers of acrosomal status, fluorochromes detecting altered sperm chromatin or DNA integrity, vital dyes revealing sperm mitochondrial activity, probes detecting apoptotic events, and antibodies detecting proteins that are either up- or down-regulated in defective spermatozoa. Many of the above biomarkers are best tested by flow cytometry, permitting rapid, automated, high throughput, objective measurement of the relative abundance of these biomarkers in semen. This review summarizes a strategy for the identification of novel male fertility/sperm quality biomarkers based on proteomic, biochemical and immunocytochemical analyses of defective spermatozoa. This approach identifies proteins or ligands uniquely associated with defective spermatozoa, regardless of whether they carry gross morphological defects or subtle, but critical hidden defects (e.g. DNA strand breaks) not detected with conventional, light microscopic analysis. Such markers, including ubiquitin, sperm thioredoxin SPTRX3/TXNDC8, 15LOX, and Lewisγ-terminated N-glycans, are associated with poor semen quality and reduced fertility, warranting a designation of "negative" markers of fertility. The significance of sperm cytoplasmic droplet, a structure that accumulates several of the discussed biomarker proteins, is also discussed with regard to sperm quality and fertility.
An Integrated Hybrid Silicon Multiwavelength AWG Laser (2011)

The first integrated multiwavelength laser based on an arrayed waveguide grating (AWG) fabricated on a silicon-on-insulator wafer is presented. It consists of Fabry-Perot cavities integrated with hybrid silicon amplifiers and an intracavity filter in the form of an AWG with a channel spacing of 360 GHz. Four-channel lasing operation is shown. Single-sided fiber-coupled output powers as high as 35 μW are measured. The device shows subnanosecond rise and fall times, and direct modulation at 1 GHz gives an open eye with an extinction ratio of 7.7 dB.
Three diacylglycerol acyltransferases contribute to oil biosynthesis and normal growth in Yarrowia lipolytica (2011)

Diacylglycerol (DAG) acyltransferase catalyses the final and committed step of triacylglycerol biosynthesis. Eukaryotes commonly contain up to three distinct classes of DAG acyltransferases: acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2), and phospholipid:diacylglycerol acyltransferase (PDAT). The non-conventional oleaginous yeast, Yarrowia lipolytica, contains at least one homologue of each class and serves as a good model to understand the role of different DAG acyltransferases in the biosynthesis of oil, a critical cellular component that serves as a storage molecule as well as a buffer for free fatty acids. We used gene disruptions in Y. lipolytica and in vitro enzyme assays to confirm the identity of genes encoding all three DAG acyltransferases and demonstrate that together they account for almost all oil biosynthesis and that all three contribute significantly to its oil biosynthesis. In Y. lipolytica ATCC 20362 strain, the total lipid% dry cell weight (DCW) as a percentage of the wild-type strain in pdat, dgat1, dgat2, dgat1/dgat2 double mutant and dgat1/dgat2/pdat triple mutant was 70%, 57%, 36%, 18% and 13%, respectively.This is the first example of DGAT1 contributing significantly to oil biosynthesis in a microorganism. The triple mutant shows significant growth defect in both increased lag phase and slower growth rate, suggesting that oil biosynthesis contributes to normal growth in this strain.
Artificial negative permeability based on a fractal Jerusalem cross (2009)

In recent years new fabrication methods have led to electromagnetic structures not previously possible to create at sub-wavelength sizes, opening up an entirely new field of engineering: metamaterials. These sub-wavelength structures can lead to new properties not found in nature, such as a negative index of refraction, which has been demonstrated to yield a working cloaking device. This field presents a new degree of freedom to designers but there are several issues preventing the ease of design found in more established fields. One of the problems with creating metamaterial structures is presented in the analysis of such structures. With structures of sub-wavelength size analysis has been shown to be valid if the metamaterial is considered a homogeneous material, but traditional analysis methods are unable to treat these structures as such. Thus, new analysis methods have been devised. A robust method of effective material parameter retrieval is implemented in this research with several well-known structures to demonstrate its effectiveness. The well-known structures of metamaterial research, such as split-ring resonators (SRR) and complementary electric L-C (CELC) resonators, have well-documented issues such as narrowband resonant responses, high losses, and polarization sensitivity. Metamaterial designers typically deal with a structure which simulates an artificial magnetic material, as with the aforementioned SRR and CELC structures. The novelty of this field has led many, if not most, researchers to deal either entirely with SRRs or structures very similar to them. The robust analysis method implemented in this research was used to design and characterize new metamaterial unit particles with improvements over the traditional SRRs and CELCs. Following initial design the new particles were simulated using Ansoft’s industry-standard electromagnetic simulation tool, HFSS. These simulations yielded scattering parameters for the new structures, permitting the robust analysis method to extract effective material parameters. The unit particles were designed with the goals of increasing polarization independence and making multi-band structures, enabling flexibility for designers not available with existing metamaterial unit particles. Particles based on a fractal Jerusalem Cross provided the multi-band capability not found in existing structures and increased rotational independence of the structure.
The Virtual Cinematographer: A Paradigm for Automatic Real-Time Camera Control and Directing (2023)

This paper presents a paradigm for automatically generating complete camera specifications for capturing events in virtual 3D environments in real-time. We describe a fully implemented system, called the Virtual Cinematographer, and demonstrate its application in a virtual "party" setting. Cinematographic expertise, in the form of film idioms, is encoded as a set of small hierarchically organized finite state machines. Each idiom is responsible for capturing a particular type of scene, such as three virtual actors conversing or one actor moving across the environment. The idiom selects shot types and the timing of transitions between shots to best communicate events as they unfold. A set of camera modules, shared by the idioms, is responsible for the low-level geometric placement of specific cameras for each shot. The camera modules are also responsible for making subtle changes in the virtual actors? positions to best frame each shot. In this paper, we discuss some basic heuristics of filmmaking and show how these ideas are encoded in the Virtual Cinematographer.
Broadband Music: Opportunities and Challenges for Multiple Source Localization (2007)

It is well-known that the subspace MUltiple SIgnal Classification (MUSIC) method provides high-resolution spatial spectral estimates in narrowband signal environments. However, for broadband signals, such high-resolution methods still elude researchers. This paper proposes a broadband version of the MUSIC method using a parameterized version of the spatial correlation matrix. The proposed algorithm utilizes both inter-microphone amplitude and phase differences; as a result, simulation results show that the proposed method allows two broadband sources which are not resolvable by conventional steered beamforming to be accurately resolved.
Object-oriented methods: A foundation (1994)

Presents the concepts and techniques that support almost any system development approach, involving computers, people or machines. This book considers object structure, object behaviour and concepts like composition, diagrams, meta-modelling and power types. It also outlines design considerations.
High-Speed, Highly Fluorous Organic Reactions (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTHigh-Speed, Highly Fluorous Organic ReactionsKristofer Olofsson, Sun-Young Kim, Mats Larhed, Dennis P. Curran, and Anders HallbergView Author Information Department of Organic Pharmaceutical Chemistry, BMC, Uppsala University, Box 574, SE-75123 Uppsala, Sweden, and Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 Cite this: J. Org. Chem. 1999, 64, 12, 4539–4541Publication Date (Web):May 19, 1999Publication History Received28 December 1998Published online19 May 1999Published inissue 1 June 1999https://pubs.acs.org/doi/10.1021/jo982511yhttps://doi.org/10.1021/jo982511ybrief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views624Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical reactions,Electromagnetic radiation,Irradiation,Organic reactions,Solvents Get e-Alerts
Memantine-induced brain activation as a model for the rapid screening of potential novel antipsychotic compounds: Exemplified by an mGlu2/3 receptor agonist (2010)

peer reviewed
The Empirical Comparative Study on Portfolio Insurance Investment Strategies for Collective DC Plans with Guaranteed Return (2022)

최근 근로자퇴직급여보장법의 일부개정을 통하여 영세근로자의 안정적인 투자수익률 제고를 위해 집합투자확정기여형퇴직연금제도(Collective DC: CDC)인 중소기업퇴직연금기금제도를 도입하였다. 특히, 중소기업퇴직연금기금과 같이 공적 성격이 강한 CDC 연기금의 경우 제도 도입의 효과를 제고 하기 위해 최소보장수익률 제공을 고려할 필요성이 있다. 본 연구는 CDC 연기금이 최소보장수익률을 제공할 경우 포트폴리오보험(Portfolio Insurance: PI) 전략을 투자전략으로 선정하고 유형별 PI전략을 적용할 경우 보증준비금과 이율보증부담률을 낮추기 위해 적합한 투자전략을 제시하였다. 보증준비금 산출 모형은 변액연금보험에서 사용하는 방법론을 활용하였으며, 적립금평가액 산출을 위해 기존의 CPPI, TIPP 전략과 TIPP 전략을 확장한 “(가칭)Flexible Portfolio Insurance(FPI)”전략을 적용하였다. 통계적 시나리오분석 결과 투자의 하방리스크를 강화하는 TIPP 전략이 가장 낮은 보증준비금을 보인 반면, 위험자산 가격흐름에 유연하게 대응하는 FPI 전략이 상승국면을 제외한 모든 시장국면에서 낮은 이율보증부담률을 보였다. 즉, 보증준비금은 투자전략의 하방리스크와 대칭적으로 발생하는 반면, 이율보증부담률은 절대 운용성과와 비대칭적인 관계를 보였다. 이러한 관점에서 CDC 연기금이 가입자에게 최소보장수익률 제공을 고려할 경우 합리적인 최소보장수익률 수준의 설정 못지않게 투자전략 선정의 중요성을 확인하였다. 따라서 본 연구를 바탕으로 향후 폭넓은 접근방법에 의한 실증연구는 지속되어야 하며, 이러한 다양한 투자전략에 대한 연구는 CDC제도의 역할 향상에 기여할 것으로 사료된다.
GaN lasers for quantum technologies (2019)

Quantum technologies containing key GaN laser components will enable a new generation of precision sensors, optical atomic clocks and secure communication systems for many applications such as next generation navigation, gravity mapping and timing since the AlGaInN material system allows for laser diodes to be fabricated over a wide range of wavelengths from the u.v. to the visible. We report our latest results on a range of AlGaInN diode-lasers targeted to meet the linewidth, wavelength and power requirements suitable for optical clocks and cold-atom interferometry systems. This includes the [5s<sup>2</sup>S<sub>1/2</sub>-5p<sup>2</sup>P<sub>1/2</sub>] cooling transition in strontium<sup>+</sup> ion optical clocks at 422 nm, the [5s<sub>2</sub><sup>1</sup>S<sub>0</sub>-5p<sup>1</sup>P1] cooling transition in neutral strontium clocks at 461 nm and the [5s<sup>2</sup>s<sub>1/2</sub>-6p<sup>2</sup>P<sub>3/2</sub>] transition in rubidium at 420 nm. Several approaches are taken to achieve the required linewidth, wavelength and power, including an extended cavity laser diode (ECLD) system and an on-chip grating, distributed feedback (DFB) GaN laser diode.