gebhart/patrepeval huggingface dataset:
Phase I study of CHP-HER2 polyvalent cancer vaccine, HER2 protein combined with a novel nanoparticle antigen delivery system of cholesteryl hydrophobized polysaccharides (2005)

2523 Background: Cholesteryl hydrophobized polysacharide-HER2 protein complex (CHP-HER2) is a cancer vaccine with a novel nanoparticle antigen delivery system, which is a complex of hydrophobized polysaccharides, pullulan (CHP) and truncated HER2 protein. Antigen-presenting cells, after incorporating CHP-HER2, can process the HER2 protein and present both MHC class I and class II-binding peptides, suggesting immunization with CHP-HER2 elicits both CD8+ and CD4+ T cell responses against HER2 antigens. Methods: Phase I trial of CHP-HER2 vaccine (LUD01–016) were conducted for HLA-A2402-positive patients with HER2-expressing refractory cancers. CHP-HER2 vaccine was subcutaneously injected every two weeks for three times at the dose of 300 micrograms of HER2 protein. The endpoints were its toxicity and specific immune reactions to HER2 antigens. Results: Nine patients were enrolled, including four patients with breast cancer, two with non-small cell lung cancer, and one each with pancreatic, urinary pelvic, and nasal cavity cancer. Adverse events were transient skin reactions at the injection sites (grade I) in all nine patients. No other adverse events were seen. During the trial, no tumor responses were observed, where eight cases with stable disease and one with progressive disease were seen. The median period of time-to-progression was 5 months. In all patients with more than three vaccinations, IgG antibodies against HER2 protein were detected. Western blot analysis showed that the antibodies also specifically reacted with the full-length HER2 molecules. For T cell immune responses, we prepared autologous PHA-stimulated CD4+ blasts (T-APCs) transduced with mRNA encoding HER2. The T-APC cells were used both for in vitro T cell stimulation and for target cells in ELISPOT assays. Specific CD8+ and CD4+ T cells became detectable after eight vaccinations, which subsequently increased in frequency with additional vaccinations. HER2-specific T-cell immune responses have been detected in three out of six vaccinated patients to date. Conclusions: CHP-HER2 is safe, and it induces both humoral and cellular immune responses to HER2 antigens. No significant financial relationships to disclose.
The Use of Flow Improvers to Decrease Pressure Drop in Multiphase Pipelines (2002)

Experiments were performed in a 10-cm diameter, 44 m long Plexiglas pipes, multiphase flow loop to examine the effect of flow improver in slug flow at inclinations of ±5degrees. Superficial liquid velocities between 0.5 and 1.5 m/s and superficial gas velocities between 2 and 6 m/s were studied. A 2.5 cP oil at 25 °C was used and water cut was 10%. The experiments were undertaken at a pressure of 0.13 MPa and a temperature of 25 °C with carbon dioxide as the gas. The effectiveness of flow improver on pressure drop and slug frequency was examined for concentrations ranging from 0 ppm to 50 ppm. The results showed that the flow improver was effective in reducing the pressure drop significantly at all superficial liquid and gas velocities. The flow improver concentration of 50 ppm was more effective than 25 ppm for all cases. At superficial gas velocities of less than 4 m/s and all liquid velocities with 50 ppm flow improver, the effectiveness of flow improver in upward flow was around 30%. At superficial liquid and gas velocities of 1.0 and 2 m/s with 50 ppm flow improver concentration, the effectiveness of up to 64% was achieved in downward flow. The slug frequency in both upward and downward flows decreased significantly in all cases with addition of flow improver. For example, at superficial liquid and gas velocities of 1.5 and 2 m/s, the slug frequency in downward flow decreased from 43 to 14 slugs/min. when 50 ppm of chemical was added. The flow pattern in downward flow was changed from slug flow to stratified flow at several velocities, which led to a large decrease in the pressure drop.
The Ga core exciton at unrelaxed GaAs (110) (1980)

Core excitonic effects at an unrelaxed GaAs (110) surface are studied using a localized orbital approach. A realistic Hamiltonian for the conduction bands is obtained with inclusion of 5s orbitals and third nearest neighbor interactions. The binding energies of core excitons both in the bulk and at the surface are calculated. The results are in good agreement with experimental measurements, with a contact potential of ∠l.0 eV. In addition it is shown that the binding energy has a maximum value and the limiting case can be thought of as an ideal vacancy.
Carrier Mobilities in Organic Electron Transport Materials Determined from Space Charge Limited Current (2001)

We report the mobility in organic electron transport materials determined from current–voltage characteristics in the regime of space charge limited current. The electron mobilities obtained are highly dependent on applied electric field, similar to the cases using a conventional time-of-flight method. The electron mobilities of phenanthroline derivatives are high and comparable to hole mobilities of conventional hole transport materials. Two parameters, zero-field mobility and electric field activation parameter are discussed from the viewpoint of oxidation and reduction reactions. The electric field activation parameter increases gradually with the increase of ionization potential. These facts suggest that there is a good possibility for realizing low driving voltage in organic light-emitting diodes (OLEDs).
A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins (2015)

Botulinum neurotoxins (BoNTs) form a large class of potent and deadly neurotoxins. Given their growing number, it is of paramount importance to discover novel inhibitors targeting common steps of their intoxication process. Recently, EGA was shown to inhibit the action of bacterial toxins and viruses exhibiting a pH-dependent translocation step in mammalian cells, by interfering with their entry route. As BoNTs act in the cytosol of nerve terminals, the entry into an appropriate compartment wherefrom they translocate the catalytic moiety is essential for toxicity. Herein we propose an optimized procedure to synthesize EGA and we show that, in vitro, it prevents the neurotoxicity of different BoNT serotypes by interfering with their trafficking. Furthermore, in mice, EGA mitigates botulism symptoms induced by BoNT/A and significantly decreases the lethality of BoNT/B and BoNT/D. This opens the possibility of using EGA as a lead compound to develop novel inhibitors of botulinum neurotoxins.
One-to-Two Wireless Interchip Communication Link (2019)

Wireless interchip communication between adjacent ICs in extreme conditions of orthogonal antennas is studied. The use of soft/hard surfaces and symmetrical layers concepts is employed in a 1:2 wireless interchip communication link to improve the overall link budget. A Y-shaped 1:2 wireless interchip link is fabricated and tested. The simulated results are validated by measurements.
Public Law 99-506, “Section 508” Electronic Equipment Accessibility for disabled workers (1988)

Article Free Access Share on Public Law 99-506, “Section 508” Electronic Equipment Accessibility for disabled workers Authors: R. E. Ladner Univ. of Washington, Washington, DC Univ. of Washington, Washington, DCView Profile , F. A. McDonough General Services Administration General Services AdministrationView Profile , W. Roth Center for Computing and Disability, SUNY Albany Center for Computing and Disability, SUNY AlbanyView Profile , L. A. Scadden Electronics Industries Foundation Electronics Industries FoundationView Profile , G. C. Vanderheiden Trace Research and Development Center Trace Research and Development CenterView Profile Authors Info & Claims CHI '88: Proceedings of the SIGCHI Conference on Human Factors in Computing SystemsMay 1988 Pages 219–222https://doi.org/10.1145/57167.57204Online:01 May 1988Publication History 5citation418DownloadsMetricsTotal Citations5Total Downloads418Last 12 Months13Last 6 weeks8 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Luminescence from Self‐Trapped Excitons and Energy Transfers in Vacancy‐Ordered Hexagonal Halide Perovskite Cs2HfF6 Doped with Rare Earths for Radiation Detection (2022)

Abstract Compared to halides Cs 2 HfX 6 (X = Cl, Br, I) with a vacancy‐ordered cubic double perovskite structure, the halide Cs 2 HfF 6 (CHF), with a hexagonal Bravais lattice, possesses a higher mass density and chemical stability for radiation detection. Luminescence properties and energy transfer mechanisms of rare‐earths‐doped CHF materials are studied here. The structure of CHF is identified as a new type of vacancy‐ordered hexagonal perovskite, with the same type of building blocks of the double perovskite but stacked with single layers. Density‐functional theory calculations reveal a large bandgap of CHF. A broad emission is observed from the pristine CHF host, which is suggested to be associated with self‐trapped excitons (STEs). A series of rare‐earths‐doped materials are designed utilizing the STE emissions, and efficient energy transfers from STEs and Tb 3+ to Eu 3+ are achieved for tunable emissions. The codoped material shows stable emission under X‐ray irradiation, with 10.2% reduction from its initial emission intensity, associated with possible structural evolution by radiation‐induced deformation of the soft host. The radiation responses of singly and codoped materials are evaluated, and the codoped material is found to be more sensitive to the radiation energy than the singly doped or pristine CHF for radiation detection.
Application of cationic polymerization to grafting and coating of silica particles (1998)

Abstract The cationic polymerization of electron rich monomers such as vinyl ethers, vinyl furane, and cyclopentadiene on silica surfaces can be initiated by aryl methyl halides. The reactions yield always soluble polymers (by heterogeneous catalysis) and novel polymer/silica hybrid materials. The link between polymer and solid is caused by covalent Si‐O‐C bonds, by network formation of the polymers during the chain growth, or by a combination of both of them. The analysis of the polymer structures on the surface by 1 H MAS NMR spectroscopy in suspension and by solid state 13 C CP MAS NMR spectroscopy is described. Proof of Si‐O‐C bonds via DRIFT spectroscopy and 13 C CP MAS NMR spectroscopy is given. The most effective method of irreversibly linking the polymer to the silica surface is the network formation. Polyvinyl ethers are bound strongly to the surface, as can be shown by FTIR measurements, but the linkage is not stable due to the Si‐O‐C bonds' susceptibility to hydrolysis. Poly‐cyclopentadienes (PCPD) are linked to the surface by Si‐O‐C bonds, which show an extraordinary high resistance to acids and bases. Si‐O‐C bond formation of poly‐2‐vinyl furane could not yet be detected by 13 C CP MAS NMR spectroscopy and DRIFT spectroscopy. In this case the high degree of coating derives from the bifunctionality of 2‐vinyl furane: it may undergo Friedel‐Crafts‐alkylation at the 5‐position of the furane ring as well as chain polymerization via the vinyl group at the 2‐position.
No evidence for viral transcripts in dermatofibrosarcoma protuberans (2019)

International audience
A Curative Method for Primary Gushing of Beer and Carbonated Beverages: Characterization and Application of Antifoam Based on Hop Oils (2014)

J. Am. Soc. Brew. Chem. 72(1):12-21, 2014 Gushing is the vigorous overfoaming of carbonated beverages when the bottle is opened. Primary gushing in beer is mostly caused by a group of proteins called hydrophobins secreted by filamentous fungi, which contaminate CO2 gaseous molecules during carbonation and form nanobubbles. The influence of hop oil antifoam on primary gushing showed a complete suppressing effect in sparkling water, a decreasing effect in wort, and no influence on gushing-positive beers. This shows the importance of the critical point of addition of this product in the brewing process. GC and GC-MS analysis show that commercial available lipophilic hop extract comprises fatty acids, either saturated fatty acids (SFA) or unsaturated fatty acids (UFA) (both free and incorporated in mono-, di-, and triglycerides), waxes (long-chain alkanes), and steroid compounds. Gushing analysis of each compound showed that SFA and UFA behave in a different manner regarding gushing. In contrast to SFA and trans-form UFA, cis-form UFAs do not induce gushing. Long-chain alkanes provide sufficient hydrophobic structures to interact with gaseous CO2 molecules and induce gushing. Because hop antifoam molecules are hydrophobic, they interact with hydrophobins and prevent interaction with CO2 and, consequently, inhibit the possibilities of development of the explosive nanobubble structure.
A wide‐band lumped circuit model of the terminal and internal electromagnetic response of coaxially insulated windings mounted on a core (2003)

Abstract This paper presents a wide‐band lumped circuit model of coaxially insulated windings mounted on a core. The polyphase model can be used to simulate the terminal and internal electromagnetic response in Dryformer TM , a new oil‐free power transformer, and similar electromagnetic power devices. The circuit parameters are based on geometrical and material data. The simulated frequency and transient response of the lumped circuit is compared to measurements on a 20 MVA 140/6.6 kV three‐phase transformer of the Dryformer TM type. The comparison shows that the model can be used to estimate resonance frequencies and transient overvoltages in the transformer, although the damping is not accurately modelled. The influence of the core is discussed and investigated.
The Human Plasma Proteome: History, Character, and Diagnostic Prospects (2003)

Vol. 1 (2002) 845–867The Human Plasma Proteome: History, Character, and Diagnostic ProspectsN. Leigh Anderson and Norman G. AndersonPage 856, Fig. 3: The positions of proteins on the figure was incorrect. The correct figure is shown following. Vol. 1 (2002) 845–867The Human Plasma Proteome: History, Character, and Diagnostic ProspectsN. Leigh Anderson and Norman G. AndersonPage 856, Fig. 3: The positions of proteins on the figure was incorrect. The correct figure is shown following. The Human Plasma Proteome: History, Character, and Diagnostic ProspectsN. Leigh Anderson and Norman G. AndersonPage 856, Fig. 3: The positions of proteins on the figure was incorrect. The correct figure is shown following. N. Leigh Anderson and Norman G. Anderson Page 856, Fig. 3: The positions of proteins on the figure was incorrect. The correct figure is shown following.
Intergeneric transfer and functional expression of the tomato disease resistance gene Pto. (1995)

Plant disease resistance loci have been used successfully in breeding programs to transfer traits from resistant germplasm to susceptible plant cultivars. The molecular cloning of plant disease resistance genes now permits the transfer of such traits across species boundaries by genetic transformation of recipient hosts. The tomato disease resistance gene Pto confers resistance to strains of the bacterial pathogen Pseudomonas syringae pv tomato expressing the avirulence gene avrPto. Transformation of Nicotiana benthamiana with Pto results in specific resistance to P. s. pv tabaci strains carrying avrPto. The resistant phenotype is manifested by a strong inhibition of bacterial growth and the ability to exhibit a hypersensitive response. Resistance cosegregates with the Pto gene in transgene selfings and testcrosses. Our results demonstrate the conservation of disease resistance functions across genus boundaries and suggest that the utility of host-specific resistance genes can be extended by intergeneric transfer.
Measurement of synchrotron x-ray energies and line shapes using diffraction markers (1982)

Standard reference markers for accurate, reproducible synchrotron x-ray energies are obtained using a three Si crystal spectrometer. The first two crystals are in the monochromator and the third is used to obtain diffraction markers which monitor the energy. Then for any value of the glancing angle on the reference Si crystal the energy for the (333) diffraction must occur at 3/4 that of the (444) and 3/5 of that for the (555). This establishes for the first time an absolute synchrotron energy scale. Higher-order diffractions are used to determine excitation line profiles. We conclude that the use of reference diffractions is necessary to measure reproducible x-ray energies and to analyze the incident photons’ line profile. The detection of diffractions near the edge of measurement and near the Cu edge will provide a fast secondary standard which will allow comparison of edge data between different laboratories. The diffraction profiles will allow the proper analysis of spectral line widths.
L‐2: Late‐News Paper : A 2.2‐inch, Narrow Frame Liquid Crystal System Display with Low Voltage Interface Circuitry (2006)

Abstract A 2.2‐inch, QVGA format system display, which fully integrates a low voltage 6‐bit RGB parallel interface circuit, has been developed by using low temperature poly‐Si (LTPS) TFT technology. This panel integrates a low voltage (1.8V) interface circuit, which directly connects to an external controller LSI. We also have developed a horizontal driver that allows for the narrowest frame width to date in mobile displays.
Biosynthesis of the antiparasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea (2001)

In the above article, which was published in Volume 37, Issue 4, on pages 752–762, the statement in the text and in Figs 1, 2 and 4 that l-megosamine is identical to l-rhodosamine is incorrect. l-Megosamine differs in stereochemistry from l-rhodosamine at carbons 3 and 4. In Figs 1 and 2, the structure of megosamine was drawn incorrectly. The hydroxyl and methyl substituents shown as equatorial should be axial. In Fig. 4, the compounds depicted in the l-megosamine pathway are also drawn with the incorrect stereochemistry. The corrected Fig. 4 is shown on the following page. Proposed biosynthetic pathways for synthesis of the deoxysugars involved in erythromycin and megalomicin synthesis. Similar routes to desosamine and mycarose have been previously proposed in erythromycin biosynthesis (Gaisser et al. 1997; Summers et al. 1997) and for desosamine in methymycin/picromycin biosynthesis (Zhao et al. 1998).
A Predictive Model for Force-Sensing Resistor Nonlinearity for Pressure Measurement in a Wearable Wireless Sensor Patch (2018)

Implementation of a Pressure Ulcer Prevention System would prevent pressure ulcers, ease workload on caregivers, enabling patient treatment and monitoring outside a hospital setting, and reduce health care costs. Accurate measurement of pressure is an important criteria in order to achieve the above said goals. A challenge associated with using Force-Sensing Resistors (FSRs) as a pressure sensor is the part-to-part variability of up to ±25%. This paper presents a novel modeling technique for correcting force sensor nonidealities, without requirement of prior knowledge of material parameters, and enabling measurement accuracies of ±2% over a pressure range of 1N to 5N.
Impact of sedation vs. general anaesthesia on percutaneous epicardial access safety and procedural outcomes (2016)

Choice of anaesthesia for EpiAcc does not appear to significantly affect safety and procedural or clinical outcomes. For patients in whom anaesthesia may pose increased risk, it is reasonable to obtain epicardial access under sedation.
Using a Saliency Map for Active Spatial Selective Attention: Implementation & Initial Results (1994)

In many vision based tasks, the ability to focus attention on the important portions of a scene is crucial for good performance on the tasks. In this paper we present a simple method of achieving spatial selective attention through the use of a saliency map. The saliency map indicates which regions of the input retina are important for performing the task. The saliency map is created through predictive auto-encoding. The performance of this method is demonstrated on two simple tasks which have multiple very strong distracting features in the input retina. Architectural extensions and application directions for this model are presented.
Ground-Based NDVI Sensing: Separating the Ground Surface from the Cotton Canopy (2015)

<abstract> <b><sc>Abstract.</sc></b> A normalized difference vegetation index (NDVI) sensor can be used for nondestructively assessing the nitrogen (N) status of crops. When deployed as a mobile ground-based sensor for variable-rate cropping applications, its readings can be influenced by the irregular or sparse canopy coverages of the ground surface. The soil and ground stubble backgrounds that are periodically exposed within the sensorâs view will generate erroneous readings. The objective of this research was to develop an algorithm that improves an NDVI-based instrumentation systemâs ability to discriminate between cotton plant biomass and the ground surface, thereby providing a more accurate N status for the crop. The research focused on N concentration assessment as a measure of N status; hence, eliminating the exposed soil background became essential. Algorithms were developed to correct the errors resulting from irregular cotton populations. A statistical analysis of field data taken using manipulated crop populations highlighted two effective algorithms.
Olodaterol Attenuates Citric Acid-Induced Cough in Naïve and Ovalbumin-Sensitized and Challenged Guinea Pigs (2015)

Excessive coughing is a common feature of airway diseases. Different G-protein coupled receptors, including β2-adrenergic receptors (β2-AR), have been implicated in the molecular mechanisms underlying the cough reflex. However, the potential antitussive property of β2-AR agonists in patients with respiratory disease is a matter of ongoing debate. The aim of our study was to test the efficacy of the long-acting β2-AR agonist olodaterol with regard to its antitussive property in a pre-clinical model of citric acid-induced cough in guinea pigs and to compare the results to different clinically relevant β2-AR agonists. In our study β2-AR agonists were intratracheally administered, as dry powder, into the lungs of naïve or ovalbumin-sensitized guinea pigs 15 minutes prior to induction of cough by exposure to citric acid. Cough events were counted over 15 minutes during the citric acid exposure. Olodaterol dose-dependently inhibited the number of cough events in naïve and even more potently and with a greater maximal efficacy in ovalbumin-sensitized guinea pigs (p < 0.01). Formoterol and salmeterol showed a trend towards reducing cough. On the contrary, indacaterol demonstrated pro-tussive properties as it significantly increased the number of coughs, both in naïve and ovalbumin-sensitized animals (p < 0.001). In conclusion, olodaterol, at doses eliciting bronchodilation, showed antitussive properties in a model of citric acid-induced cough in naïve and ovalbumin-sensitized guinea pigs. This is in agreement with pre-clinical and clinical studies showing antitussive efficacy of β2-AR agonists. Indacaterol increased the number of coughs in this model, which concurs with clinical data where a transient cough has been observed after indacaterol inhalation. While the antitussive properties of β2-AR agonists can be explained by their ability to lead to the cAMP-induced hyperpolarization of the neuron membrane thereby inhibiting sensory nerve activation and the cough reflex, the mechanism underlying the pro-tussive property of indacaterol is not known.