gebhart/patrepeval huggingface dataset:
Challenge of 1-Gb DRAM development when using optical lithography (1997)

The traditional lithographic approach employed by the semiconductor industry has been to pursue use of advanced prototype optical exposure tools and resists. The benefits of doing so have been: (1) The lithographic process that is used in development more closely resembles the process that will in fact be used to manufacture the chip. (2) The cost of low K<SUB>1</SUB> imaging (phase-masks, off-axis illumination, and surface imaging resist) can be avoided. However with the introduction of 1Gb-dynamic random access memory (DRAM) development, a paradigm shift is being experienced within the optical lithographic community. With 1Gb-DRAMs, the minimum feature size falls irreversibly below the optical wavelength used to image the feature. Such a situation will make low K<SUB>1</SUB> factor imaging unavoidable. With 175 nm groundrules typical for first generation 1G-DRAMs, K<SUB>1</SUB> factors near 0.4 will be common with 0.5 as an upper limit on advanced systems currently in development irrespective of optical wavelength. This paper will cover the selection process, experimental data, and problems encountered in defining and integrating the lithographic process used to support the critical mask levels on 1Gb-DRAM development. Factors considered include: resist, masks, and illuminations via both simulation and experiment. The simulations were conducted with both internal and externally developed software. The experimental data to be reviewed was generated using an experimental 0.6 NA KrF step and scan system provided by Nikon. The resist used is commercially available from the Shipley corporation.
Impact of water activity on oil expression from oil seeds (2012)

11th World Filtration Congress, WFC11, Gratz, Austria, April 16-20, 2012.
TxA2 inhibition and ischemia-induced loss of myocardial function and reactive hyperemia (1990)

To determine the contribution of thromboxane (Tx) A2 release in reperfusion injury, 17 dogs were subjected to total coronary occlusion for 1 h and reperfusion for 1 h. Eleven dogs were treated with saline, and six were treated with selective TxA2 synthetase inhibitor U63,557A (5 mg/kg iv) 30 min before coronary artery occlusion. In all saline-treated dogs, peak reactive hyperemia after 10-s total coronary artery occlusion was diminished (P less than 0.01) after reperfusion. Myocardial segmental shortening was also reduced (9.8 +/- 1.9 to -6.7 +/- 2.0%, P less than 0.01) in the reperfused region. Reperfusion was associated with 737 +/- 343 premature ventricular contractions (PVCs) per hour. Histology revealed extensive myocardial infiltration and capillary plugging by leukocytes in the reperfused region. Myeloperoxidase, an index of leukocyte infiltration, was also increased (P less than 0.02) in the reperfused region. In the U63,557A-treated animals, serum and plasma TxB2 levels were markedly (P less than 0.02) reduced. Decrease in myocardial shortening fraction was less in U63,557A- than in saline-treated animals (P less than 0.05). The frequency of reperfusion PVCs was also significantly reduced (10 +/- 5 PVCs/h, P less than 0.02 compared with saline-treated dogs). However, peak reactive hyperemia was reduced similar to that in saline-treated dogs. Myocardial infiltration and capillary plugging by leukocytes in the reperfused regions was also similar in the U63,557A- and saline-treated dogs. These results indicate that treatment with U63,557A decreases reperfusion arrhythmias and preserves myocardial function. However, coronary reperfusion-induced deterioration in reactive hyperemia is not affected.(ABSTRACT TRUNCATED AT 250 WORDS)
Passive and semi-active targeting of bone marrow and leukemia cells using anionic low cholesterol liposomes (2016)

Historically, the use of liposomes to enhance delivery of anticancer agents to cancer cells has focused primarily on solid tumors, which are characterized by rapid angiogenesis resulting in a poorly formed hypervasculature with abnormal vessel walls. The leaky vasculature in combination with poor lymphatic drainage has been demonstrated to lead to the accumulation of liposomes via the enhanced permeation and retention effect. However, only very limited information exists on the disposition of such delivery systems in the bone marrow compartment, the primary site of tumor cell origination and growth for many hematological malignancies. In this review we discuss the biological properties of anionic low-cholesterol liposome formulations and their potential for passively accumulating within the bone marrow and being selectively engulfed by leukemia cells compared to normal bone marrow cells. The therapeutic implications for preferential bone marrow delivery as well as the potential routes for the internalization of drug-encapsulated liposomes into cells in the absence of a targeting ligand are reviewed.
Novel Family of Carbohydrate Esterases, Based on Identification of the Hypocrea jecorina Acetyl Esterase Gene (2008)

ABSTRACT Plant cell walls have been shown to contain acetyl groups in hemicelluloses and pectin. The gene aes1 , encoding the acetyl esterase (Aes1) of Hypocrea jecorina , was identified by amino-terminal sequencing, peptide mass spectrometry, and genomic sequence analyses. The coded polypeptide had 348 amino acid residues with the first 19 serving as a secretion signal peptide. The calculated molecular mass and isoelectric point of the secreted enzyme were 37,088 Da and pH 5.89, respectively. No significant homology was found between the predicated Aes1 and carbohydrate esterases of known families, but putative aes1 orthologs were found in genomes of many fungi and bacteria that produce cell wall-degrading enzymes. The aes1 transcript levels were high when the fungal cells were induced with sophorose, cellulose, oat spelt xylan, lactose, and arabinose. The recombinant Aes1 produced by H. jecorina transformed with aes1 under the cellobiohydrolase I promoter displayed properties similar to those reported for the native enzyme. The enzyme hydrolyzed acetate ester bond specifically. Using 4-nitrophenyl acetate as substrate, the activity of the recombinant enzyme was enhanced by d -xylose, d -glucose, cellobiose, d -galactose, and xylooligosaccharides but not by arabinose, mannose, or lactose. With the use of 4-nitrophenyl-β- d -xylopyranoside monoacetate as substrate in a β-xylosidase-coupled assay, Aes1 hydrolyzed positions 3 and 4 with the same efficiency while the H. jecorina acetylxylan esterase 1 exclusively deacetylated the position 2 acetyl group. Aes1 was capable of transacetylating methylxyloside in aqueous solution. The data presented demonstrate that Aes1 and other homologous microbial proteins may represent a new family of esterases for lignocellulose biodegradation.
Advanced Age Diminishes Tendon-to-Bone Healing in a Rat Model of Rotator Cuff Repair (2014)

With increasing age and activity level of the population, the incidence of rotator cuff tears is predicted to rise. Despite advances in rotator cuff repair technique, the retear rate remains specifically high in elderly patients. The findings of this research suggest that aging negatively influences tendon-to-bone healing after rotator cuff repair in a validated animal model.
Clinical and pathological analysis of companion diagnostic testing of microsatellite instability-high for pembrolizumab in gynaecologic malignancy (2021)

Microsatellite instability-high was less commonly detected as a companion diagnosis for pembrolizumab in unselected gynaecologic patients. Genetic counselling should be always provided along with treatment selection.
Fermentation of “Quick Fiber” Produced from a Modified Corn-Milling Process into Ethanol and Recovery of Corn Fiber Oil (2004)

Approximately 9% of the 9.7 billion bushels of corn harvested in the United States was used for fuel ethanol production in 2002, half of which was prepared for fermentation by dry grinding. The University of Illinois has developed a modified dry grind process that allows recovery of the fiber fractions prior to fermentation. We report here on conversion of this fiber (Quick Fiber [QF]) to ethanol. QF was analyzed and found to contain 32%wt glucans and 65%wt total carbohydrates. QF was pretreated with dilute acid and converted into ethanol using either ethanologenic Escherichia coli strain FBR5 or Saccharomyces cerevisiae. For the bacterial fermentation the liquid fraction was fermented, and for the yeast fermentation both liquid and solids were fermented. For the bacterial fermentation, the final ethanol concentration was 30 g/L, a yield of 0.44 g ethanol/g of sugar(s) initially present in the hydrolysate, which is 85% of the theoretical yield. The ethanol yield with yeast was 0.096 gal/bu of processed corn assuming a QF yield of 3.04 lb/bu. The residuals from the fermentations were also evaluated as a source of corn fiber oil, which has value as a nutraceutical. Corn fiber oil yields were 8.28%wt for solids recovered following pretreatment.
The Cellular Biochemistry of Cholesterol and Statins: Insights into the Pathophysiology and Therapy of Alzheimer's Disease (2004)

The causes of late onset Alzheimer disease (AD) are poorly understood. Although beta-amyloid (Abeta) is thought to play a critical role in the pathophysiology of AD, no genetic evidence directly ties Abeta to late onset AD. This suggests that the accumulation of Abeta and neurodegeneration associated with AD might result from an abnormality that indirectly affects Abeta production or accumulation. Increasing evidence suggests that abnormalities in the metabolism of cholesterol and related molecules, such as cholseterol esters and 24(S) hydroxycholesterol might contribute to the pathophysiology of late onset AD by increasing production of Abeta. 24(S) Hydroxycholesterol is a member of a family of oxidized cholesterol catabolites, termed oxysterols, which function to regulate export of cholesterol from the cell and transcription of genes related to cholesterol metabolism. Cholesterol esters are cholesterol derivatives used for cholesterol storage. Levels of 24(S) hydroxycholesterol increase with AD. Polymorphisms in several different genes important for cholesterol physiology are associated with an increased load or level of Abeta in AD. These genes include apolipoprotein E, cholesterol 24 hydroxylase (Cyp46), acyl-CoA:cholesterol acetyltransferase (ACAT), and the cholesterol transporter ABCA1. Other studies show that levels of cholesterol, or its precursors, are elevated in subjects early in the course of AD. Finally, studies of the processing of amyloid precursor protein show that cholesterol and its catabolites modulate amyloid precursor protein processing and Abeta production. These lines of evidence raise the possibility that genetic abnormalities in cholesterol metabolism might contribute to the pathophysiology of AD.
Bipolar disorder in an extended pedigree with a segregation pattern compatible with X-linked transmission (1993)

The case for a linkage between chromosome Xq27–28 and a bipolar disorder spectrum has prevailed as the most thoroughly documented in psychiatric genetics. The only reports of molecular genetic linkage to the region are obtained with the F9 gene. It is questionable whether these findings reflect linkage to the more extensively studied color blindness-G6PD area. The impact of ethnic differences has been repeatedly suggested as an explanatory factor for divergent findings with respect to the region. The population in the present study derives from a genetically isolated area. To further reduce the risk of heterogeneity, the analysis was restricted to a single extended pedigree. Investigations based on a thorough genealogical exploration revealed no suggestion of father-to-son transmission. Operationally defined criteria were applied to exclude subjects who might introduce bilineal gene flow. Diagnoses were made using translations of appropriate parts of SADS-L and SCID with the aid of family history data and systematically collected records. Using two markers, F9 and DXS548, and with a diagnostic spectrum identical to that used in the studies reporting linkage to the F9 gene, we could exclude (lod score < −2) the chromosomal region between the two markers as well as the region extending 10 cM from F9 towards the centromere and 27 cM towards the telomere.
Gross Morphology of Diseased Tissues in Nezara viridula (Hemiptera: Pentatomidae) and Molecular Characterization of an Associated Microsporidian (2022)

Nezara viridula (L.) (Hemiptera: Pentatomidae), commonly known in the U.S. as the southern green stink bug (SGSB), is a cosmopolitan, highly polyphagous feeder that causes severe damage to a wide range of agronomically important crops such as fruit, vegetable, grain, tobacco, and cotton, throughout much of the United States, and is a global pest of considerable ecological, agricultural, and economical interest. During dissection of female Nz. viridula, conspicuous black and brown spots or lesions were observed on various internal organs. To determine the cause of these spots or lesions, tissues of fat body, spermatheca, ovaries, and ovulated eggs were collected from healthy and infected individuals. The gross morphology of the spots was characterized, and the microorganisms associated with the infection were identified by amplicon sequencing of the V4 region of the small subunit rRNA gene. The presence of a microsporidian pathogen Nosema maddoxi, Becnel, Solter, Hajek, Huang, Sanscrainte, & Estep (Microsporidia: Nosematidae) which has been observed on other species of stink bug, was evidenced for the first time. The characterization of the gross morphology of this associated microsporidian may enable more rapid determination of microsporidia infection in stink bug colonies and field populations.
Preface (2020)

CIRP Conference on Biomanufacturing, CIRP-BioM 2019, Guangzhou; China, 12-15 December 2019
Mutagenesis of key residues identifies the connection subdomain of HIV‐1 reverse transcriptase as the site of inhibition by heme (2001)

We have recently demonstrated that metalloporphyrins are potent inhibitors of both human immunodeficiency virus type 1 (HIV-1) and human immunodeficiency virus type 2 (HIV-2) reverse transcriptases (RTs) [Argyris, E.G., Vanderkooi, J.M., Venkateswaran, P.S., Kay, B.K., and Paterson, Y. (1999) J. Biol. Chem. 274, 1549-1556]. In addition, by screening a phage peptide library we discovered that a peptide with sequence similarity to residues 398-407 from the connection subdomain of HIV RTs binds heme. These findings suggested that this highly conserved region may be the binding site for metalloporphyrins and a novel site for inhibition of enzymatic activity. Our most recent data presented here confirm this suggestion. Screening of HIV-1 RT 398-407 peptide analogs by fluorescence assays demonstrates that Trp residues at positions 401 and 402 are important for heme binding. Furthermore, site-directed mutagenesis of these residues verified these findings and indicated that heme inhibits HIV-1 RT by binding on the connection subdomain of the p66 subunit of the enzyme but not on the p51 subunit. This was also confirmed by analyzing the binding affinities of heme for mutant HIV-1 RT heterodimers, using intrinsic fluorescence assays. The clear identification of the connection domain as a novel inhibition site is crucial in understanding the mechanism of heme binding and enzymatic inhibition and will facilitate the generation of novel porphyrin-based inhibitors of RT.
Symbolic Data Analysis to Defy Low Signal-to-Noise Ratio in Microarray Data for Breast Cancer Prognosis (2013)

Microarray profiling has recently generated the hope to gain new insights into breast cancer biology and thereby improve the performance of current prognostic tools. However, it also poses several serious challenges to classical data analysis techniques related to the characteristics of resulting data, mainly high dimensionality and low signal-to-noise ratio. Despite the tremendous research work performed to handle the first challenge in the feature selection framework, very little attention has been directed to address the second one. We propose in this article to address both issues simultaneously based on symbolic data analysis capabilities in order to derive more accurate genetic marker-based prognostic models. In particular, interval data representation is employed to model various uncertainties in microarray measurements. A recent feature selection algorithm that handles symbolic interval data is used then to derive a genetic signature. The predictive value of the derived signature is then assessed by following a rigorous experimental setup and compared with existing prognostic approaches in terms of predictive performance and estimated survival probability. It is shown that the derived signature (GenSym) performs significantly better than other prognostic models, including the 70-gene signature, St. Gallen, and National Institutes of Health criteria.
Light-Emitting Field-Effect Transistor Based on a Tetracene Thin Film (2003)

We report the first organic light-emitting field-effect transistor. The device structure comprises interdigitated gold source and drain electrodes on a Si/SiO(2) substrate. A polycrystalline tetracene thin film is vacuum sublimated on the substrate forming the active layer of the device. Both holes and electrons are injected from the gold contacts into this layer leading to electroluminescence from the tetracene. The output characteristics, transfer characteristics, and the optical emission properties of the device are reported. A possible mechanism for electron injection is suggested.
Measurement of Gastrointestinal Intramucosal pH Is a Poor Guide to Tolerable Levels of Anemia During Isovolemic Hemodilution in a Canine Model of Coronary Stenosis (1997)

Myocardium compromised by coronary stenosis is more sensitive to normovolemic hemodilution-induced ischemia than the normally perfused gut mucosa. This limits the potential utilization of the measurement of gastrointestinal intramucosal pH as a guide to tolerable levels of anemia in critically ill patients.
Effect of System Grounding, AC-DC Converter Topology and Inverter Modulation on Motor Insulation Voltage Stress (2020)

This paper analyzes major sources of motor voltage stresses on the motor stator line-to-ground and line-to-line insulation systems. Root causes of motor insulation over-voltages produced as a result of the type of the power system grounding scheme, type of dc-bus power supply (diode front end or regenerative active converter), inverter switching schemes, and long motor power cables are analyzed and discussed. Limitations of the existing definition of the low-voltage definite-purpose inverter duty motors are highlighted in relation to the line-to-ground insulation system requirements.
The oxidation behavior of a model molybdenum/tungsten-containing alloy in air alone and in air with trace levels of NaCl(g) (1983)

Thermogravimetric, metallographic, and X-ray studies of a model alloy, Ni-(17 a/o)Al-(10 a/o)Mo+W, oxidized in dry air at 600-1200 C and in air with 10 ppm NaCl gas at 900 C, are reported. The alloy was melted under Ar and pretreated in flowing H2 for 24 h at 1300 C. Polished 1.3 x 1.3 x 0.2-cm specimens were washed and degreased prior to oxidation in a quartz tube within a furnace for up to 120 hr. The oxidation activation energy of the alloy is determined to be about 30 kcal/mole. The specimens oxidized at 900 C and hotter exhibited oxidized and nitrided phases covered by complex NiMoO4, NiWO4, and NiAl2O4 scales and a porous, nonprotective outer layer of NiO. The oxidation behavior is found to be determined by the formation and growth of the scale, especially the (Mo,W)O2 component. Al2O3 scale layers were not formed, and further runs with pure O2 or Ar-(20 percent)O2 ruled out an explanation of this phenomenon based on aluminum nitride formation. The oxidation was accelerated by the addition of NaCl gas, a finding attributed to the reaction of NaCl with external locally protective Al2O3 scales and with the internal(Mo, W)O2 layers.
Fig Supp 5 from HDAC6 Plays a Noncanonical Role in the Regulation of Antitumor Immune Responses, Dissemination, and Invasiveness of Breast Cancer (2023)

&lt;p&gt;Fig Supp 5&lt;/p&gt;
Thermally Stable Perovskite Solar Cells by All-Vacuum Deposition (2022)

Vacuum deposition is a solvent-free method suitable for growing thin films of metal halide perovskite (MHP) semiconductors. However, most reports of high-efficiency solar cells based on such vacuum-deposited MHP films incorporate solution-processed hole transport layers (HTLs), thereby complicating prospects of industrial upscaling and potentially affecting the overall device stability. In this work, we investigate organometallic copper phthalocyanine (CuPc) and zinc phthalocyanine (ZnPc) as alternative, low-cost, and durable HTLs in all-vacuum-deposited solvent-free formamidinium-cesium lead triodide [CH(NH<sub>2</sub>)<sub>2</sub>]<sub>0.83</sub>Cs<sub>0.17</sub>PbI<sub>3</sub> (FACsPbI<sub>3</sub>) perovskite solar cells. We elucidate that the CuPc HTL, when employed in an "inverted" p-i-n solar cell configuration, attains a solar-to-electrical power conversion efficiency of up to 13.9%. Importantly, unencapsulated devices as large as 1 cm<sup>2</sup> exhibited excellent long-term stability, demonstrating no observable degradation in efficiency after more than 5000 h in storage and 3700 h under 85 °C thermal stressing in N<sub>2</sub> atmosphere.
Design kombinatorischer Leitstruktur-Bibliotheken (1999)

Die Optimierung von Leitverbindungen geringer Wirksamkeit zu Wirkstoffen geht oft mit einer Zunahme der Molekülmasse (Mr) und der Lipophilie einher. Treffer mit Affinitäten auf μM-Niveau, entdeckt durch das Durchmustern von Leitstruktur-Bibliotheken, geben diesem Optimierungsprozeß Spielraum, wie im Diagramm anhand der Verteilungen von Mr für eine Leitstruktur-Bibliothek (1), bekannte oral wirksame Arzneien (2) und eine typische kombinatorische Bibliothek (3) gezeigt ist. y=Prozentanteil mit einer bestimmten Molekülmasse.
Hard X-Ray Detector (HXD) on Board Suzaku (2007)

Abstract The Hard X-ray Detector (HXD) on board Suzaku covers a wide energy range from 10 keV to 600 keV by the combination of silicon PIN diodes and GSO scintillators. The HXD is designed to achieve an extremely low in-orbit background based on a combination of new techniques, including the concept of a well-type active shield counter. With an effective area of $142 \,\mathrm{cm}^{2}$ at 20 keV and $273 \,\mathrm{cm}^{2}$ at 150 keV, the background level at sea level reached $\sim 1 \times 10^{-5} \,\mathrm{cts} \,\mathrm{s}^{-1} \,\mathrm{cm}^{-2} \,\mathrm{keV}^{-1}$ at 30 keV for the PIN diodes, and $\sim 2 \times 10^{-5} \,\mathrm{cts} \,\mathrm{s}^{-1} \,\mathrm{cm}^{-2} \,\mathrm{keV}^{-1}$ at 100 keV, and $\sim 7 \times 10^{-6} \,\mathrm{cts} \,\mathrm{s}^{-1} \,\mathrm{cm}^{-2} \,\mathrm{keV}^{-1}$ at 200 keV for the phoswich counter. Tight active shielding of the HXD results in a large array of guard counters surrounding the main detector parts. These anti-coincidence counters, made of $\sim 4 \,\mathrm{cm}$ thick BGO crystals, have a large effective area for sub-MeV to MeV $\gamma$-rays. They work as an excellent $\gamma$-ray burst monitor with limited angular resolution ($\sim 5^{\circ}$). The on-board signal-processing system and the data transmitted to the ground are also described.