gebhart/patrepeval huggingface dataset:
Oligomeric self-association of basic fibroblast growth factor in the absence of heparin-like glycosaminoglycans (1999)

Basic fibroblast growth factor (FGF-2) represents a class of heparin-binding growth factors that are stored in the extracellular matrix attached to heparin-like glycosaminoglycans (HLGAGs). It has been proposed that cell surface HLGAGs have a central role in the biological activity of FGF-2, presumably by inducing dimers or oligomers of FGF-2 and leading to the dimerization or oligomerization of FGF receptor and hence signal transduction. We have previously proposed that FGF-2 possesses a natural tendency to self-associate to form FGF-2 dimers and oligomers; HLGAGs would enhance FGF-2 self-association. Here, through a combination of spectroscopic, chemical cross-linking and spectrometric techniques, we provide direct evidence for the self-association of FGF-2 in the absence of HLGAGs, defying the notion that HLGAGs induce FGF-2 oligomerization. Further, the addition of HLGAGs seems to enhance significantly the FGF-2 oligomerization process without affecting the relative percentages of FGF-2 dimers, trimers or oligomers. FGF-2 self-association is consistent with FGF-2's possessing biological activity both in the presence and in the absence of HLGAGs; this leads us to propose that FGF-2 self-association enables FGF-2 to signal both in the presence and in the absence of HLGAGs.
EFFECT OF PLANTING DATES, SIZE OF SETTS AND METHODS OF PLANTING ON KHARIF ONION (ALLIUM CEPA L.) PRODUCTION UNDER SUBMOUNTAIN LOW HILL CONDITIONS OF HIMACHAL PRADESH (2009)

The study conducted on kharif onion production involving planting time, size of setts and methods of planting revealed that August planting dates were the best compared to July and September dates. The setts planted on August, 16 recorded highest bulb yield of 45.1 7q/ha followed by August, 1 planted setts (1 27.63q). The size of setts also exhibited significant bearing on the bulb yield. Whereas, the largest setts (> 2.00cm) recorded highest yield of 119.00 quintals followed by 107.70 quintals from medium grade setts (1 .50-2.00cm), the smallest setts (1.50-1.00cm) recorded minimum production (67.47q), across all planting dates and methods of planting. Among the methods of plantings, raised bed method exhibited highest bulb yield (111 .3OqIha), followed by flat beds (1 06.30q), across all planting dates and size of setts.
INDOCYANINE GREEN ANGIOGRAPHIC FINDINGS IN A CASE OF ACUTE ANNULAR OUTER RETINOPATHY (2004)

HARINO, SEIYO MD; NAGAYA, CHIKAKO MD; MATSUDA, SATOSHI MD; IWAHASHI, YOSHIKO MD; UYAMA, MASANOBU MD; ÇEK;İÇ, OSMAN MD; HASHIMOTO, MIE MD Author Information
MitochondrialDNA: Fate of the Paternal Mitochondrial Genome (2019)

Abstract The mitochondrial genome encodes key proteins of the electron transfer chain, which generates the vast majority of cellular adenosine triphosphate through oxidative phosphorylation. This genome is normally transmitted to subsequent generations through the oocyte and is thus maternally inherited. Sperm mitochondrial deoxyribonucleic acid (mtDNA) is normally eliminated early during embryonic development, but this tends to be species specific. There are several interconnected mechanisms that could account for its elimination, including ubiquitin depended proteolysis, mtDNA digestion by a dedicated endonuclease and whole organelle autophagy/mitophagy. The elimination of sperm mitochondrial DNA is essential for the functional integrity of the embryo, and for the health, fitness and fertility of the offspring. Sperm mtDNA appears to harbour a large number of defects, whereas maternally inherited mitochondrial DNA rearrangements appear to be transmitted at a very low frequency. However, there is an increasing number of assisted reproductive technologies and therapies that could lead to the transmission of paternal/foreign mitochondrial DNA and this requires significant investigation. Key Concepts Mitochondria are semi‐autonomous energy‐producing organelles with their own genome (mitochondrial DNA/mtDNA) and transcriptional and translational machinery. Mitochondrial health influences fitness, health and fertility in humans and animals. In most animals and in humans, mitochondria and mitochondrial genomes are inherited clonally, from mother (the concept of ‘mitochondrial Eve’), though exceptions exist. Paternal mitochondria enter the oocyte at fertilisation but are eliminated soon thereafter by the ooplasmic autophagy/mitophagy machinery. Sperm‐borne (paternal) mitochondria are predestined for proteolysis and mitophagy as they are tagged with the recycling marker ubiquitin during the haploid phase of spermatogenesis. Elimination of paternal mitochondria is essential for an individual's health as it prevents the transmission of harmful mtDNA mutations and deletions. Paternal mitochondrial heteroplasmy caused by the leakage/recycling failure of sperm mitochondria after fertilisation has been associated with mitochondrial disease in humans. Some assisted reproductive therapies (ART) such as intracytoplasmic sperm injection (ICSI) may be liable to convey paternal mitochondrial leakage, though there is no consistent screening for it ART children.
Mid-IR fiber optic light source around 6 micron through parametric wavelength translation (2014)

We report numerically designed highly nonlinear all glass chalcogenide microstructured optical fiber for efficient generation of light around 6 micron through degenerate four wave mixing by considering continuous wave CO laser of 5 to 10 Watts power emitting at 5.6 micron as the pump. By tuning the pump wavelength, pump power, fiber dispersion and nonlinear properties, narrow and broad band mid-IR all-fiber light source could be realized. Parametric amplification of more than 20 decibel is achievable for the narrow band source at 6.46 micron with a maximum power conversion efficiency of 33 percent while amplification of 22 decibel is achievable for a B-band source over the wavelength range of 5 to 6.3 micron with a conversion efficiency of 40 percent.
Chemistry of 2,3-dihydro-2-metallaphenalenes. Part 1. Synthesis of CHRSiMe2CHR′C10H6(R = R′= H; R = R′= SiMe3; and R,R′= H,SiMe3) and formation of the compound [{Li(Me2NCH2CH2NMe2)}2{CHSiMe2C(SiMe3)C10H6}]via decomposition of [{Li(Me2NCH2CH2NMe2)}2{1,8-(CHSiMe3)2C10H6}]; crystal structures of two polymorphs of the silicon heterocycle dilithium complex (1984)

The complexes [{Li(tmen)}2{1,8-(CHSiMe3)2C10H6}](9)(tmen =NNN′N′-tetramethylethylenediamine) and [{Li(tmen)}{[graphic omitted]10H6}](13) have been prepared via metallation of species formed by in situ Grignard trapping reactions of 1,8-(ClCH2)2C10H6 with SiMe3Cl and SiMe2Cl2 respectively; synthesis of the siline, meso-[graphic omitted]10H6 from (9) is also described. In hexane, (9) decomposes to [{Li(tmen)}2{[graphic omitted]10H6}](10) to yield the compound [graphic omitted]10H6 on the addition of aqueous HCl, the same product as that obtained from a reaction of (13) with SiMe3Cl. The nature of (10) has been established by X-ray structure determination of two polymorphs, α and β, which differ both in the mode of interaction of the Li(tmen)+ moieties with the carbanion [η6:η3(α), cf.η4:η3(β)] and the conformation of the heterocyclic ring.
The simulation of tug operations in a multiple simulator environment (2021)

Ship handling simulators have included the effects of tugs for some time. The simulation of tugs has ranged from simple vector tugs to more complex models with various levels of interaction between the tug and the assisted ship. The availability of multiple Ship handling simulators in one facility has provided the opportunity for complete interactive real time simulations of tug operations for training and research projects. This paper describes the issues associated with the simulation of tugs and the implementation of fully interactive tug simulations, using multiple simulators. In particular, the modeling and transfer of the tow line and pushing forces between simulators are addressed. A key issue is the stability of the simulation integration with the rapidly changing forces that occur in both tow line and pushing mode. The experience with interactive tug handling studies from a number of research and training projects is discussed.
An object addressing mechanism for statically typed languages with multiple inheritance (1989)

In this paper we are concerned with addressing techniques for statically typed languages with multiple inheritance. The addressing techniques are responsible for the efficient implementation of record field selection. In object-oriented languages, this record selection is equivalent to the access of methods. Thus, the efficiency of these techniques greatly affects the overall performance of an object-oriented language. We will demonstrate that addresses, in such systems, cannot always be calculated statically and show how symbol tables have been used as address maps at run time. The essence of the paper is a new addressing technique that can statically calculate either the address of a field or the address of the address of the field. This technique is powerful enough to support an efficient implementation of multiple inheritance with implicit subtyping as described by Cardelli.
Pan-Cancer Analysis of Canonical and Modified miRNAs Enhances the Resolution of the Functional miRNAome in Cancer (2022)

Modified miRNAs may act as cancer biomarkers and function as allies or antagonists of their canonical counterparts in gene regulation, suggesting the concurrent consideration of canonical and modified miRNAs can boost patient stratification.
Pyrolysis of Poly(ferrocenylsilanes): Synthesis and Characterization of Ferromagnetic Transition-Metal-Containing Ceramics and Molecular Depolymerization Products (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrolysis of Poly(ferrocenylsilanes): Synthesis and Characterization of Ferromagnetic Transition-Metal-Containing Ceramics and Molecular Depolymerization ProductsRuth Petersen, Daniel A. Foucher, Ben-Zhong Tang, Alan Lough, Nandyala P. Raju, John E. Greedan, and Ian MannersCite this: Chem. Mater. 1995, 7, 11, 2045–2053Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/cm00059a010https://doi.org/10.1021/cm00059a010research-articleACS PublicationsRequest reuse permissionsArticle Views447Altmetric-Citations108LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Oral colonization and immune responses toStreptococcus gordoniiexpressing a pertussis toxin S1 fragment in mice (2002)

The ability of a recombinant Streptococcus gordonii RJM4 expressing the N-terminal 179-amino acid fragment of S1 subunit of pertussis toxin (PT) as a SpaP/S1 fusion protein was tested for oral colonization and immunogenicity in BALB/c mice. Following two consecutive oral inoculations, 100% of the mice were colonized by the recombinant strains for up to 9 weeks and >60% of the animals still retained the strains after 19 weeks. RJM4 recovered from the animals continued to express the SpaP/S1 fusion protein indicating the stability of the fusion gene in vivo. Secretory (S) IgA antibody against PT could be detected in saliva from RJM4-colonized mice but not from the control groups of mice. SIgA against SpaP was also detected in saliva from the RJM4-inoculated and the S. gordonii SL3 (control)-inoculated mice. Serum antibodies against PT and SpaP were not detected in these animals. In conclusion, long-term oral colonization of BALB/c mice with our recombinant S. gordonii was established and the colonization elicited mucosal antibodies against PT and SpaP.
Probing contact-mode characteristics of silicon nanowire electromechanical systems with embedded piezoresistive transducers (2015)

This article reports on a new method of monitoring nanoscale contacts in switches based on nanoelectromechanical systems, where the contact-mode switching characteristics can be recorded with the sensitive embedded piezoresistive (PZR) strain transducers. The devices are manufactured using state-of-the-art wafer-scale silicon-on-insulator technology featuring suspended silicon cantilevers and beams as switching elements and sub-100 nm thin silicon nanowires (SiNWs) as PZR transducers. Several different device configurations are studied, including mechanically 'cross'-shaped ('+'), coupled cantilever-SiNW structures, with and without local drain electrodes, and doubly clamped SiNW beams. Through detailed measurement and analysis, we demonstrate that the PZR transducers can enable detection of both mechanical and tunneling switching with multiple repeatable cycles. With the strong PZR effects in thin SiNWs, this type of device could be valuable especially for monitoring cold switching events, and when conventional direct readout of the switching events from the local gate or drain electrodes would not be efficient or sensitive, as nanoscale contacts may not be highly conductive, or may be degrading over time.
President's Message (2023)

On behalf of the Instrumentation and Measurement Society (IMS) I welcome you all to this special edition of the Instrumentation and Measurement Magazine, constituted by selected papers presented during AUTOTESTCON 2022. The Conference Committee has carried out a thorough review process to accept the papers presented at the conference. Subsequently, a few authors were invited to submit an extended version of their papers to conform this special issue with an orientation to wide audiences. As you can see, the Best Student Paper and Best Technical Paper are also proudly included in this edition. I would like to congratulate the authors, editors and reviewers for his valuable work in making this happen.
Oxygen in sputter‐deposited ZnTe thin films (2006)

Abstract Bandgap‐bowing has been observed in many of the zinc‐group‐VI compounds, when the anion is substituted with an isovalent element. Recently new results on the ZnO 1–x S x and ZnO 1–x Se x system have been presented, but so far only one report on ZnO 1–x Te x is known. We examine the possibility of substituting tellurium by oxygen in sputter‐deposited polycrystalline ZnTe thin‐films and the effects on bandgap energy and crystal structure. A first approximation of the bowing curve with a lower limit of the bowing parameter of 2.7 eV is performed. (© 2006 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration (2015)

Glutamate carboxypeptidase II (GCP-II) is a brain metallopeptidase that hydrolyzes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to NAA and glutamate. Small molecule GCP-II inhibitors increase brain NAAG, which activates mGluR3, decreases glutamate, and provide therapeutic utility in a variety of preclinical models of neurodegenerative diseases wherein excess glutamate is presumed pathogenic. Unfortunately no GCP-II inhibitor has advanced clinically, largely due to their highly polar nature resulting in insufficient oral bioavailability and limited brain penetration. Herein we report a non-invasive route for delivery of GCP-II inhibitors to the brain via intranasal (i.n.) administration. Three structurally distinct classes of GCP-II inhibitors were evaluated including DCMC (urea-based), 2-MPPA (thiol-based) and 2-PMPA (phosphonate-based). While all showed some brain penetration following i.n. administration, 2-PMPA exhibited the highest levels and was chosen for further evaluation. Compared to intraperitoneal (i.p.) administration, equivalent doses of i.n. administered 2-PMPA resulted in similar plasma exposures (AUC0-t, i.n./AUC0-t, i.p. = 1.0) but dramatically enhanced brain exposures in the olfactory bulb (AUC0-t, i.n./AUC0-t, i.p. = 67), cortex (AUC0-t, i.n./AUC0-t, i.p. = 46) and cerebellum (AUC0-t, i.n./AUC0-t, i.p. = 6.3). Following i.n. administration, the brain tissue to plasma ratio based on AUC0-t in the olfactory bulb, cortex, and cerebellum were 1.49, 0.71 and 0.10, respectively, compared to an i.p. brain tissue to plasma ratio of less than 0.02 in all areas. Furthermore, i.n. administration of 2-PMPA resulted in complete inhibition of brain GCP-II enzymatic activity ex-vivo confirming target engagement. Lastly, because the rodent nasal system is not similar to humans, we evaluated i.n. 2-PMPA also in a non-human primate. We report that i.n. 2-PMPA provides selective brain delivery with micromolar concentrations. These studies support intranasal delivery of 2-PMPA to deliver therapeutic concentrations in the brain and may facilitate its clinical development.
Optical network transformation: The way to solve bandwidth limitation (2012)

The ever increasing bandwidth-hungry applications trigger an unexpected transformation in telecommunication networks. This influences all network layers, with the highest impact in layer zero, L0.
An Update on Scaffold Devices for Rotator Cuff Repair (2017)

The annual volume of rotator cuff repairs in the United States is roughly 250,000, and failure rates still range from 20% to 70% in most studies despite significant advances in surgical technique and rehabilitation protocols. Even many “healed” repairs continue to have pain, weakness, and dysfunction, a phenomenon that may be explained by “Failure with continuity,” where the healing tendon retracts from the repaired location without a structural defect, leaving interposed scar tissue. To improve clinical outcomes, there is a need to minimize the rate of structural failure and minimize the failure with continuity that occurs after rotator cuff repair. Scaffold devices, in the form of extracellular matrix or synthetic grafts, hold promise in their abilities to mechanically and/or biologically augment repair sites. However, these devices can be technically challenging to apply, and the surgeon must be proficient in their use. To justify the increased operative time and cost associated with their use, we must also demonstrate the ability of these devices to improve structural and clinical outcomes.
Generation of Wavelength-Tunable Optical Pulses Using EDFA as External-Injection Light Source and Amplifier for Fabry–PÉrot Laser Diode (2004)

We propose and experimentally demonstrate a system for the generation of wavelength-tunable pulses using a gain-switched Fabry-Pe/spl acute/rot laser diode (FPLD) and an erbium-doped fiber amplifier (EDFA). The EDFA is used as both an external-injection light source and an amplifier for the FPLD. The wavelength tuning is achieved by a tunable filter. The optical sidemode suppression ratio of this system is better than 32 dB over the wavelength-tunable range of 34.5 nm. Moreover, the repetition frequency is 2000 MHz, and the pulsewidth is between 49.3 and 65.3 ps. The whole system is simple and can be easily constructed.
Semi-2-interpenetrating polymer networks of high temperature systems (1985)

A semi-interpenetrating (semi-IPN) polymer system of the semi-2-IPN type is described in which a polymer of acetylene-terminated imidesulfone (ATPISO2) is cross linked in the presence of polyimidesulfone (PISO2). Six different formulations obtained by mixing of either ATPISO2-1n or ATPISO2-3n with PISO2 in three different proportions were characterized in terms of glass transition temperature, thermooxidative stability, inherent viscosity, and dynamic mechanical properties. Adhesive (lap shear) strength was tested at elevated temperatures on aged samples of adhesive scrim cloth prepared from each resin. Woven graphite (Celion 1000)/polyimide composites were tested for flexural strength, flexural modulus, and shear strength. The network polymers have properties intermediate between those of the component polymers alone, have greatly improved processability over either polyimide, and are able to form good adhesive bonds and composites, making the semi-2-IPN systems superior materials for aerospace structures.
mobileVision (2014)

We present mobileVision -- a portable, robust, smartphone-based ophthalmoscopy prototype intended to reduce the barriers to ocular pathology screening in developing and underserved regions. In contrast to currently available retinal imaging solutions, mobileVision provides the portability of a handheld ophthalmoscope without sacrificing retinal field-of-view or resolution. Through tight integration with a smartphone and ergonomic design, we demonstrate novel features for such a small form factor, including: automatic compensation for patient refractive error, voice-activated multi-shot retinal image acquisition without pupil dilation (non-mydriatic), and touch-gesture based control of patient fixation and accommodation. We further demonstrate a computational lucky imaging and retinal stitching pipeline which not only increases overall retinal field-of-view, but also makes the system robust to patient saccades, blinks, device jitter, and imaging artifacts such as noise or unintended scattering from ocular surfaces. We estimate through mock eye tests that the mobileVision prototype is capable of imaging the retina with 23.5μm of retinal resolution for patients with between −6 D to +13 D refractive error, and we image over ±45° of retina during an in vivo trial.
PNA synthesis using a novel Boc/acyl protecting group strategy (2001)

The synthesis of novel Boc/acyl protected monomers for the synthesis of peptide nucleic acid (PNA) is described. The oligomerization protocol using these new monomers has been optimized with regard to coupling reagents. The use of base-labile acyl protecting groups at the exocyclic amines of the heterocyclic bases (isobutyryl for guanine and benzoyl for adenine and cytosine) and a PAM-linked solid support offers an attractive alternative to the present procedures used in PNA synthesis. This strategy has been applied for the synthesis of a test 17mer PNA on both control pore glass (CPG) and a polystyrene MBHA support and was used in the preparation of PNA–DNA chimeras. Copyright © 2001 European Peptide Society and John Wiley & Sons, Ltd.
<title>Integrated force array: interface to external systems</title> (1997)

Integrated Force Arrays (IFAs) are thin film linear actuators which operate with substantial displacement and force. The methods of attachment of these devices to external systems are under development. Our current methods to incorporate IFAs in an scanning ultrasound imaging systems as well as a new material and method for attachment will be described.