gebhart/patrepeval huggingface dataset:
Giant room temperature compression and bending in ferroelectric oxide pillars (2022)

Plastic deformation in ceramic materials is normally only observed in nanometre-sized samples. However, we have observed high levels of plasticity (>50% plastic strain) and excellent elasticity (6% elastic strain) in perovskite oxide Pb(In<sub>1/2</sub>Nb<sub>1/2</sub>)O<sub>3</sub>-Pb(Mg<sub>1/3</sub>Nb<sub>2/3</sub>)O<sub>3</sub>-PbTiO<sub>3</sub>, under compression along <100><sub>pc</sub> pillars up to 2.1 μm in diameter. The extent of this deformation is much higher than has previously been reported for ceramic materials, and the sample size at which plasticity is observed is almost an order of magnitude larger. Bending tests also revealed over 8% flexural strain. Plastic deformation occurred by slip along {110} <1[Formula: see text]0 > . Calculations indicate that the resulting strain gradients will give rise to giant flexoelectric polarization. First principles models predict that a high concentration of oxygen vacancies weaken the covalent/ionic bonds, giving rise to the unexpected plasticity. Mechanical testing on oxygen vacancies-rich Mn-doped Pb(In<sub>1/2</sub>Nb<sub>1/2</sub>)O<sub>3</sub>-Pb(Mg<sub>1/3</sub>Nb<sub>2/3</sub>)O<sub>3</sub>-PbTiO<sub>3</sub> confirmed this prediction. These findings will facilitate the design of plastic ceramic materials and the development of flexoelectric-based nano-electromechanical systems.
Usefulness of periostin as a biomarker of pediatric asthma (2015)

<b>Background:</b> There few biomarkers of asthma which can be easily assessed for clinical use, especially in children. Periostin is an extracellular matrix protein and is upregulated by IL-4 and IL-13 stimulation from airway epithelial cells and other structural cells. Serum periostin is expected as a non-invasive biomarker for asthma diagnosis and management. <b>Purpose:</b> To assess the usefulness of serum periostin levels as a clinical biomarker of pediatric asthma. <b>Method:</b> 29 asthmatic children (BA) and 27 non-asthma control children (Cont) were investigated (6-16 years). Bronchial asthma was diagnosed by ISAAC medical questionnaire, and methacholine challenge test was performed for BA. Comorbid diseases including heart disease, renal disease, skeletal disease and atopic dermatitis were excluded. FeNO, lung function, blood eosinophil counts, serum levels of IgE, periostin were assessed. The diagnostic accuracy of these markers to identify asthma was calculated using receiver operating characteristics area under the curve (ROC AUC). <b>Results:</b> Mean PC20 of methacholine was 1.1 mg/ml. Serum periostin levels in BAwas significantly higher than in Cont (mean ± SD: 138.3 ± 34.9 vs 119.2 ± 35.0 ng/ml,p&lt;0.05). FeNO levels and eosinophil counts in BA were also significantly higher than in Cont. ROC AUC for periostin, FeNO, eosinophil counts, PEF, FEV<sub>1.0</sub> and MMF were 0.68, 0.72, 0.80, 0.59, 0.60 and 0.67 respectively. <b>Conclusion:</b> Periostin levels in BA were significantly higher in comparison with Cont. ROC AUC for periostin was equivalent to conventional biomarkers, such as FeNO and lung function, suggesting the usefulness of periostin in the diagnosis of asthma in children.
Pressure-Induced Enhancement of Giant Magnetoresistance due to Crossover of Interlayer Exchange Coupling inFe/CrMultilayers (2007)

We report the first observation of a large pressure-induced enhancement of giant magnetoresistance (GMR) in magnetic multilayers (MML). In Fe/Cr MMLs with the Cr layer thickness of approximately 30 A, a crossover from biquadratic to bilinear interlayer exchange coupling (IEC) was observed by applying pressure, and simultaneously the GMR under high pressure (>2 GPa) was enhanced to be twice as large as that at ambient pressure. The enhanced GMR is attributed to the suppression of the biquadratic IEC by applying pressure, and the electrical resistivity in parallel alignment of magnetization also showed a crossover behavior, suggesting an electronic origin for the observed pressure effects.
A Glycoprotein Set Specifically Associated with the Surface and Cytosol of Human Breast Carcinoma Cells (1978)

Abstract A new glycoprotein set, specifically associated with human breast carcinoma cells, has been identified, purified to homogeneity, and characterized. This glycoprotein set was first identified in the perchloric acid-soluble glycoprotein fraction of human ductal carcinoma of the breast after removal of known glycoproteins by affinity chromatography. Prototype antiserum to this glycoprotein, after absorption with normal tissues, reacted by gel diffusion with a single constituent of breast tumors but not with other benign or malignant tissues. This antiserum was used to isolate two types of soluble mammary tumor-associated glycoprotein (MTGP). Both types of MTGP appeared to have m.w. of about 19,500 and possess common antigenic determinants. In addition, a firmly integrated insoluble form of MTGP was identified. The soluble types of MTGP differed one from the other in respect to: a) isoelectric point, b) sedimentation velocity, c) carbohydrate composition, and d) buoyant density in cesium chloride. MTGP was found in all six metastatic breast tumors and was independent from plasma and tissue glycoproteins. Antisera to purified MTGP of Types I and II both gave reactions of identity one with the other and with both types of aqueous soluble MTGP. Each antiserum reacted only with extracts of breast tumors and not with any other tissue or type of tumor. MTGP was localized by immunohistochemical methods to both the surface and the cytoplasm of breast ductal carcinoma cells but not normal ductal cells. Positive reactions were also observed in immunologic assays with some spontaneous murine mammary carcinomas but not with the mouse mammary tumor virus. MTGP appears to provide a discrete and characterized new marker for breast carcinoma cells and thus a candidate tumor-specific antigen.
Cytologic Diagnosis of Blastocystis hominis in Peritoneal Fluid (2008)

The present case highlights the unusual identification ofextraintestinal forms of B hominis in a peritoneal fluid sample from a patient with invasive, poorly differentiated adenocarcinoma and associated bowel perforation.
Perpendicular Magnetic Anisotropy in CoFeB/Pd Bilayers (2010)

Perpendicular magnetic anisotropy is observed in ultrathin (~ 0.6 nm) amorphous Co <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">40</sub> Fe <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">40</sub> B <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">20</sub> when sputtered on an MgO (001) buffer layer and capped with Pd. The layers are superparamagnetic with a blocking temperature of ~ 230 K, below which they show an exponential temperature dependence of coercivity. Perpendicular magnetic anisotropy is observed in the as-deposited state and the mechanism is different from that of CoFeB/Pt, which requires postannealing. These ultrathin layers could be a model system for studies of electric field effects on magnetic anisotropy.
Truncated CSF3 receptors induce pro‐inflammatory responses in severe congenital neutropenia (2022)

Severe congenital neutropenia (SCN) patients are prone to develop myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML). Leukaemic progression of SCN is associated with the early acquisition of CSF3R mutations in haematopoietic progenitor cells (HPCs), which truncate the colony-stimulating factor 3 receptor (CSF3R). These mutant clones may arise years before MDS/AML becomes overt. Introduction and activation of CSF3R truncation mutants in normal HPCs causes a clonally dominant myeloproliferative state in mice treated with CSF3. Paradoxically, in SCN patients receiving CSF3 therapy, clonal dominance of CSF3R mutant clones usually occurs only after the acquisition of additional mutations shortly before frank MDS or AML is diagnosed. To seek an explanation for this discrepancy, we introduced a patient-derived CSF3R-truncating mutation in ELANE-SCN and HAX1-SCN derived and control induced pluripotent stem cells and compared the CSF3 responses of HPCs generated from these lines. In contrast to CSF3R-mutant control HPCs, CSF3R-mutant HPCs from SCN patients do not show increased proliferation but display elevated levels of inflammatory signalling. Thus, activation of the truncated CSF3R in SCN-HPCs does not evoke clonal outgrowth but causes a sustained pro-inflammatory state, which has ramifications for how these CSF3R mutants contribute to the leukaemic transformation of SCN.
Dual Role of Quantum Dots as Color Conversion Layer and Suppression of Input Light for Full-Color Micro-LED Displays (2021)

In micro-light-emitting diode (micro-LED) displays with color-conversion layers, a facile and efficient technology getting rid of the use of the color filters leads to a big technical leap in cost-effective fabrication. In this study, it is demonstrated that quantum dot (QD) color conversion layers can significantly suppress residual blue excitation light because of the high extinction coefficients of QDs, ∼0.1% transmittance of blue light for green and red core/shell CdSe/ZnS QD film with thickness of less than 17 μm, and produce green and red colors. Incorporation of TiO<sub>2</sub> nanoparticles into QD solutions enhances more than 10% of the luminous intensity by the scattering effect. It is found that the suppression of QD reabsorption is essential to achieve a high color-conversion efficiency. Our results provide a clear path to a cost-effective fabrication of QD conversion layer micro-LED displays over the full range of their applications.
Exploiting Fully Integrated Inductive Voltage Regulators to Improve Side Channel Resistance of Encryption Engines (2016)

This paper explores fully integrated inductive voltage regulators (FIVR) as a technique to improve the side channel resistance of encryption engines. We propose security aware design modes for low passive FIVR to improve robustness of an encryption-engine against statistical power attacks in time and frequency domain. A Correlation Power Analysis is used to attack a 128-bit AES engine synthesized in 130nm CMOS. The original design requires ~250 Measurements to Disclose (MTD) the 1st byte of key; but with security-aware FIVR, the CPA was unsuccessful even after 20,000 traces. We present a reversibility based threat model for the FIVR-based protection improvement and show the robustness of security aware FIVR against such threat.
The effect of F0 inhibitors on the Vibrio alginolyticus membrane ATPase (1991)

The inhibition of membrane ATPase from the marine alkalotolerant bacterium Vibrio alginolyticus by DCCD, triphenyltin and venturicidin was studied. DCCD proved to be an irreversible inhibitor, while venturicidin and triphenyltin produced a reversible inhibitory effect. The DCCD-binding proteolipid was identified in the membrane preparations. The effect of the inhibitors on ATPase activity and ATP-dependent Na(+)-transport in V. alginolyticus subcellular vesicles is discussed.
Supplementary Figures S1-S4 from PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer (2023)

&lt;p&gt;Supplementary Figures S1-S4&lt;/p&gt;
BPZT HBARs for Magnetoelastic Stress Generation at GHz Frequencies (2020)

The high-frequency performance of strong piezoelectric materials like Pb(Zr<sub>1-x</sub>Ti<sub>x</sub>)O<sub>3</sub> (PZT) remains relatively less explored due to the assumption of large dielectric/ferroelectric losses at gigahertz (GHz) frequencies. Recently, the advent of magnetoelectric technology as an on-chip route to excite magnetization dynamics has provided the impetus to evaluate the electromechanical performance of PZT at microwave frequencies. In this article, we demonstrate that high-overtone bulk acoustic resonators fabricated using barium-doped PZT (BPZT) films can efficiently generate acoustic waves up to 15 GHz. The ferroelectricity of BPZT endows added functionality to the resonator in the form of voltage tunability of the electromechanical performance. We extract the piezoelectric coefficient by numerically comparing the performance of BPZT with the Mason model. The extracted piezoelectric coefficient approximately 60 pm/V agrees well with reported values on a thin-film PZT measured at low frequencies (<100 MHz). Our results suggest that with further improvement in device design and material processing, BPZT resonators could operate as large amplitude, tunable stress transducers at GHz frequencies.
A Fast pH‐Switchable and Self‐Healing Supramolecular Hydrogel Carrier for Guided, Local Catheter Injection in the Infarcted Myocardium (2013)

Minimally invasive intervention strategies after myocardial infarction use state-of-the-art catheter systems that are able to combine mapping of the infarcted area with precise, local injection of drugs. To this end, catheter delivery of drugs that are not immediately pumped out of the heart is still challenging, and requires a carrier matrix that in the solution state can be injected through a long catheter, and instantaneously gelates at the site of injection. To address this unmet need, a pH-switchable supramolecular hydrogel is developed. The supramolecular hydrogel is switched into a liquid at pH > 8.5, with a viscosity low enough to enable passage through a 1-m long catheter while rapidly forming a hydrogel in contact with tissue. The hydrogel has self-healing properties taking care of adjustment to the injection site. Growth factors are delivered from the hydrogel thereby clearly showing a reduction of infarct scar in a pig myocardial infarction model.
Surface-Enhanced Light Olefin Yields during Steam Cracking (2000)

Various papers have shown enhanced olefin yields during steam cracking when a catalytic surface is introduced. Our studies reveal that increased light olefin yields during catalytic steam cracking are mainly due to a surface volume effect and not to a traditional catalytic effect. Augmentation of yields is also observed if inert material is introduced. We showed that this increase in ethene yield is not an artifact of altered radial or axial heat and mass transfer in the reactor arising from the presence of a packed bed. As a result, the surface-to-volume ratio mainly determines the increase in yields with respect to the homogeneous steam-cracking process. The main effects of the potassium-containing catalyst appear to be suppression of coking activity.
Metal-Alloyed NbS2 Nanotubes Synthesized by the Self-Assembly of Nanoparticles (2002)

Ag- and Nb-alloyed NbS2 nanotubes (see Figure for a TEM image of Ag-NbS2) are the first nanotubes grown by self-assembly of NbS2 nanoparticles. As growth precursors for such doped nanotubes, silver-alloyed (NbS4)xI needle crystals were used. The important stage of the growth technique is the interconversion of two-dimensional structures via an intermediate with one-dimensional needle geometry.
An Asymmetric Nitro‐Mannich Reaction Applicable to Alkyl, Aryl, and Heterocyclic Imines. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Isosteric Replacement of Carbon with Silicon in the Design of Safer Chemicals (1996)

Organosilanes are inexpensively made, lack intrinsic toxicity, and have many similarities to comparable carbon compounds. Isosteric replacement of carbon with silicon in compounds with desirable properties can lead to products with enhanced environmental degradation, or other safety features. Many examples of silicon substitution have been studied in agrochemicals and pharmaceuticals. Application of this strategy to agrochemicals, where environmental concerns are paramount, has been particularly successful. An unsuccessful application of this isosteric replacement strategy is also instructive. Three case studies, and the current understanding of the environmental fate of organosilanes, are discussed.
Label-free optical detection of circulating tumor cell clusters using confocal back scatter and fluorescence flow cytometry (2021)

Rare circulating tumor cells (CTCs) and circulating tumor cells clusters (CTCCs) have been shown to increase the metastatic potential of tumors, with CTCCs increasing metastatic potential by 23 to 50 times. Due to the high metastatic potential of CTCCs, there is a growing interest in the detection and isolation of these clusters to improve diagnosis, stratification, and treatment of cancer patients. This study aims to utilize a custom confocal back scatter and fluorescence flow cytometer (CBSFFC) that will leverage the high sensitivity of flow cytometers for in vitro and in vivo detection of CTCCs without the use of exogenous contrast agents.
Determination of Composition and Lattice Relaxation in Semipolar Ternary (In,Al,Ga)N Strained Layers from Symmetric X-ray Diffraction Measurements (2011)

We present a new method to simultaneously determine the composition and strain state for thin (In,Al,Ga)N layers grown in semipolar orientations using the data from one symmetric on-axis reciprocal space map or four symmetric on-axis rocking curve X-ray measurements. The method makes use of the one-dimensional nature of lattice mismatch relaxation in semipolar III–nitride heterostructures via operation of a unique slip system, i.e., (a/3) <1120> (0001) in the basal plane. The correlation between lattice tilt and misfit dislocation density is applied to determine the degree of relaxation, whereas the composition is found from the Bragg's law accounting for the change in planar spacing in elastically strained anisotropic wurzite (In,AlGa)N layers.
Concurrent turbo-decoding (2002)

The turbo-decoding algorithm can be viewed as a message passing procedure on a graph. We contrast the standard "forward-backward" turbo-decoding algorithm with a new "concurrent" algorithm that is suited to parallel implementation.
Prescription Trends—Brand-name Drugs vs Generic (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Miniature microstrip patch antenna loaded with a space‐filling transmission line based on the fractal Hilbert curve (2003)

Abstract A novel miniature antenna loaded with a space‐filling shaped transmission line is presented. Return loss and antenna gain results are compared with a traditional square patch. Experimental results show that the antenna presents an electrical area 18 times less than the square patch. © 2003 Wiley Periodicals, Inc. Microwave Opt Technol Lett 38: 311–312, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.11046
Implicit and Explicit Numerical Methods for Macroscopic Traffic Flow Models: Efficiency and Accuracy (2009)

Macroscopic models are used to describe traffic flow. In a simulation the model equations are discretized in both space and time. Time discretization, despite its importance to numerical stability and accuracy, has not received much attention. Most current implementations apply explicit time integration methods, which need to obey to strict stability conditions. These may result in large computing times and prevent the implementation of macroscopic traffic flow models to applications where computational efficiency is crucial, such as real time applications. The authors describe and study implicit time integration methods which have less strict stability conditions, can be used with larger time steps and reduce the computing time. Furthermore, we study the accuracy of the numerical methods. The widely used root mean square error does not take into account the nature of the error. We propose two accuracy measures which take into account errors that are important to applications in traffic flow. The phase error measures a shift of the solution over time. Numerical diffusion indicates that the solution is too 'smooth'. The authors compare explicit and implicit schemes with simple test problems for computing time and accuracy. The authors found that implicit schemes, in these cases, result in 9 to 15 times smaller computing times. However, the accuracy and the nature of the error depends on the time integration method, but can be kept at an acceptable level for computationally efficient schemes. This shows that implicit time integration methods can play a key role in applications where small computing times are crucial.
Multifractal modelling of rainfall time series (2009)

The literature produced in the last thirty years about the high space-time variability of rainfall deals with the development of stochastic models capable of representing the non-linearity and intermittence of rainfall to downscale information on rainfall fields to spatial and temporal scales useful for hydrological models, i.e. transferring to finer scales the information on rainfall observed or forecasted at large scales.
Clinical Assessment of a Plastic Optical Fiber Stylet for Human Tracheal Intubation (1999)

Novices using the imaging stylet produce fewer cases of sore throat (compared with direct laryngoscopy) and can intubate faster than when using a bronchoscope in anesthetized adult patients. The imaging stylet may be a useful aid for tracheal intubation, especially for those unable to maintain skills with a bronchoscope.
Heterogeneous programmable logic block architectures (2003)

In this paper we propose four new heterogeneous programmable logic blocks (PLBs) consisting of a combination of various sizes of look up tables (LUTs), multiplexers (MUXes), and logic gates. We demonstrate that these PLBs offer significant performance and density benefits over more homogeneous PLBs.
Anterolateral Tenodesis or Anterolateral Ligament Complex Reconstruction: Effect of Flexion Angle at Graft Fixation When Combined With ACL Reconstruction (2017)

In combined anterolateral procedure plus intra-articular ACL reconstruction, the knee flexion angle is important when fixing the graft. A modified Lemaire procedure restored intact knee laxities when fixation was performed at 0°, 30°, or 60° of flexion. The ALL procedure restored normal laxities only when fixation occurred in full extension.
Polarization Ray Tracing In Birefringent Media (1988)

A method which uses a single algorithm to trace rays in isotropic media and both ordinary and extraordinary rays in uniaxial media is presented. This method is designed to be compatible with conventional raytracing algorithms so that it is easily integrated into existing raytracing programs. A discussion of ray doubling in systems containing multiple uniaxial elements is also presented.
Wide Dynamic Range Specific Detection of Therapeutic Drugs by Photonic Crystal Microcavity Arrays (2015)

Six orders of magnitude wide dynamic range (0.1ng/ml to over 100g/ml), label-free detection of gentamicin small molecules with silicon photonic crystal microcavity biosensors multiplexed by multimode interference power splitters was experimentally demonstrated. Detection specificity was confirmed.