gebhart/patrepeval huggingface dataset:
Supplemental Figures from CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling (2023)

&lt;p&gt;Fig. S1. Expression of CRM1 in EWS cell lines. Fig. S2. Treatment of KPT-330 caused tolerable cytotoxic effect in normal CD34+ cells. Fig. S3.p53 is regulated to drive KPT-330 dependent anti-proliferation effect in wildtype EWS cell lines. Fig. S4. KPT-330 has modest effect on regulation of other fusion proteins. Fig. S5. Combination of KPT-330 and Crizotinib synergistically inhibited cell proliferation in EWS cell lines. Fig. S6. Venn diagram of genes co-downregulated by KPT-330 compared with genes downregulated by EWS-FLI1.&lt;/p&gt;
Lead Contamination in Selected Foods from Riyadh City Market and Estimation of the Daily Intake (2010)

This study was carried out to determine lead contamination in 104 of the representative food items in the Saudi diet and to estimate the dietary lead intake of Saudi Arabians. Three samples of each selected food items were purchased from the local markets of Riyadh city, the capital of Saudi Arabia. Each pooled sample was analyzed in triplicate by ICP-AES after thorough homogenization. Sweets (0.011-0.199 μg/g), vegetables (0.002-0.195 μg/g), legumes (0.014-0.094 μg/g), eggs (0.079 μg/g), meat and meat products (0.013-0.068 μg/g) were the richest sources of lead. Considering the amounts of each food consumed, the major food sources of lead intake for Saudi can be arranged as follows: vegetables (25.4%), cereal and cereal products (24.2%), beverages (9.7%) sweets (8.2%), legumes (7.4%), fruits (5.4%) milk and milk products (5.1%). The daily intake of lead was calculated taking into account the concentration of this element in the edible part of the daily consumption data which were derived from two sources, (a) the KSA food sheet provided by the Food and Agriculture Organization (FAO) and (b) from questionnaires distributed among 300 families in Riyadh city. The results showed that the daily intakes of lead according to the two sources are 22.7 and 24.5 μg/person/day respectively, which are lower than that mentioned by The Joint Expert Committee on Food Additives (JECFA), whereas it is comprabale with that of other countries.
<title>Introduction to multiprotocol over ATM (MPOA)</title> (1997)

Multiprotocol over ATM (MPOA) is a new protocol specified by the ATM Forum. MPOA provides a framework for effectively synthesizing bridging and routing with ATM in an environment of diverse protocols and network technologies. The primary goal of MPOA is the efficient transfer of inter-subnet unicast data in a LAN Emulation (LANE) environment. MPOA integrates LANE and the next hop resolution protocol (NHRP) to preserve the benefits of LAN Emulation, while allowing inter-subnet, internetwork layer protocol communication over ATM VCCs without requiring routers in the data path. It reduces latency and the internetwork layer forwarding load on backbone routers by enabling direct connectivity between ATM-attached edge devices (i.e., shortcuts). To establish these shortcuts, MPOA uses both routing and bridging information to locate the edge device closest to the addressed end station. By integrating LANE and NHRP, MPOA allows the physical separation of internetwork layer route calculation and forwarding, a technique known as virtual routing. This separation provides a number of key benefits including enhanced manageability and reduced complexity of internetwork layer capable edge devices. This paper provides an overview of MPOA that summarizes the goals, architecture, and key attributes of the protocol. In presenting this overview, the salient attributes of LANE and NHRP are described as well.
Neutron Imaging of Water Accumulation in the Active Area and Channel-to-Manifold Transitions of a PEMFC (2013)

Management of liquid water formed by the electrochemical fuel cell reaction is a key factor in PEMFC performance and durability. For practical stack applications, an important consideration is the transport of liquid water at the transition between the ends of the bipolar plate channels and the manifolds, where excess reactant flows from all the individual cells are combined and directed to the stack exhaust. In this region, gas-phase momentum can be very low, especially on the anode, where there is little driving force to remove liquid water that may accumulate as a result of geometrical or surface energy variations, or due to relatively low temperatures that exist outside of the fuel cell active area. This study seeks to characterize the water accumulated within the active area and at the channel-to-manifold transition regions at both the anode and cathode outlets, as a function of cell operating temperature and current density. The neutron imaging method was applied to directly measure the water volumes within the transition regions, and provide a comparison to simultaneously measured water volume within the cell active area. Transition-region water was found to be weakly dependent on current density, suggesting that once water forms in this area, little driving force exists to extract it entirely by means of gas momentum. Moreover, it was found that the active area water volume is strongly dependent on cell temperature, and temperature variation of as little as 0.5 °C can produce a significant change in water accumulation which is reflected in the cell voltage.
Supported organometallic complexes: Surface chemistry, spectroscopy, and catalysis. Progress report, July 15, 1989--July 14, 1990 (1991)

Adsorbing organometallic molecules onto the surfaces of inorganic supports such as Al{sub 2}O{sub 3}, MgCl{sub 2}, SiO{sub 2}, etc. can result in dramatic enhancements in catalytic activity. The reasons for this and the structures of the resulting surface organometallic centers are not well understood. We have addressed this problem using thorium, uranium, and early transition metal complexes as model adsorbates. Characterization tools include catalytic and stoichiometric reaction chemistry, reaction kinetics and isotopic labeling, quantitative poisoning studies, model solution chemistry, and a wide array of surface-sensitive physicochemical techniques such as CPMAS, NMR, EPR, and optical spectroscopy as well as titration calorimetry.
Discrete optimization of ray potentials for semantic 3D reconstruction (2015)

Dense semantic 3D reconstruction is typically formulated as a discrete or continuous problem over label assignments in a voxel grid, combining semantic and depth likelihoods in a Markov Random Field framework. The depth and semantic information is incorporated as a unary potential, smoothed by a pairwise regularizer. However, modelling likelihoods as a unary potential does not model the problem correctly leading to various undesirable visibility artifacts. We propose to formulate an optimization problem that directly optimizes the reprojection error of the 3D model with respect to the image estimates, which corresponds to the optimization over rays, where the cost function depends on the semantic class and depth of the first occupied voxel along the ray. The 2-label formulation is made feasible by transforming it into a graph-representable form under QPBO relaxation, solvable using graph cut. The multi-label problem is solved by applying α-expansion using the same relaxation in each expansion move. Our method was indeed shown to be feasible in practice, running comparably fast to the competing methods, while not suffering from ray potential approximation artifacts.
Vagally mediated low pressure baroreflex evokes biphasic changes in sympathetic nerve activity and resets the arterial baroreflex (1169.12) (2014)

Background: Although volume loading activates the low pressure baroreflex (LBR), its quantitative impact on sympathetic nerve activity (SNA) and arterial baroreflex (ABR) remains unknown. The aim of this study is to clarify how the LBR affects SNA and ABR. Methods/Results: In 10 anesthetized rats, we isolated carotid sinuses and controlled carotid sinus pressure (CSP). We infused dextran to activate LBR. We measured central venous pressure (CVP) and SNA. We fixed CSP at 90mmHg to abolish ABR. We infused dextran of 5% blood volume stepwise with or without vagotomy. In the low CVP range (2.6±0.8 to 4.5±0.7mmHg), volume loading increased SNA as much as 64.8±19.5% from the baseline, while further volume loading in the high CVP range (4.5±0.7 to 7.0±0.8 mmHg) returned SNA to the baseline level. Bilateral vagotomy totally abolished those changes in SNA. To assess the impact of LBR on the ABR central system, we changed CSP stepwise from 60 to 160 mmHg at the normal volume, mild volume loading and high volume loading while recording SNA responses. Mild volume loading (CVP: 3.8±0.6 mmHg) increased SNA by resetting the CSP‐SNA relation upward (+45.2%), while, high volume loading (CVP: 6.0±0.3 mmHg) decreased SNA by resetting the CSP‐SNA relation to the baseline level. Conclusions: Volume loading evokes biphasic changes in SNA through the resetting of CSP‐SNA relation in ABR. LBR is a powerful modulator of sympathetic nervous system.
Flexural Strength of Fiber Cementitious Composites (1994)

Peer Reviewed
Demonstration of a 280 G-bit/s communications link utilizing plane-wave multiplexing (2014)

Get PDF Email Share Share with Facebook Share on X Post on reddit Share with LinkedIn Add to Mendeley Add to BibSonomy Share with WeChat Get Citation Copy Citation Text M. P. J. Lavery, H. Huang, Y. Ren, G. Xie, and A. E. Willner, "Demonstration of a 280 G-bit/s communications link utilizing plane-wave multiplexing," in Frontiers in Optics 2014, OSA Technical Digest (online) (Optica Publishing Group, 2014), paper FTh3B.4. Export Citation BibTex Endnote (RIS) HTML Plain Text Get Video Citation alert Save article
#4297 AN ALTERNATIVE METHOD FOR SCREENING FABRY DISEASE IN WOMEN - PARTIAL RESULTS OF A BRAZILIAN STUDY (2023)

Abstract Background and Aims Fabry disease (FD) is a rare X-linked lysosomal storage disease that can affect multiple organs, including the kidneys. The main objective of this study was to evaluate the effectiveness of a combination of α-GAL enzyme activity and plasma levels of lyso-GL3 for screening FD in women with chronic kidney disease (CKD). Method Women with CKD, stages 3 to 5, in regular nephrological follow-up were selected from renal centers in all regions of Brazil. Exclusion criteria: under 18 years old and known diagnosis of CKD. Patients underwent biochemical analysis of α-GAL enzyme activity and plasma levels of lyso-GL3. GLA gene sequencing was performed if α-GAL enzyme activity was below and/or lyso-GL3 levels were above the reference range. Sensitivity and specificity analyzes were performed to evaluate the performance of the combined biochemical approach for the diagnosis of FD. Results From October 2020 to December 2022 1,647 collections were carried out. Low α-GAL activity was found in 44 (2.6%) of the cases and increased lyso-GL3 was found in 101 (6.1%) of the cases. The mean age was 53 [42 – 64] years. All cases of low α-GAL and/or increased lyso-GL3 were submitted to genetic analysis, and 6 positive cases were found. As for genetic variants, four patients have R118C, one A143T and other with T430G, all considered variants of uncertain significance (VUS). The sensitivity and specificity of α-GAL reduction for the detection of FD was 83.3% and 97.6%, respectively. As for the increase in lyso-GL3, the values were 16.6% and 93.9%, respectively. There were no cases that presented a concomitant increase in lyso-GL3 and a reduction in enzymatic activity. Conclusion Preliminary results suggest that the combination of α-GAL enzymatic activity with lyso-GL3 measurement may be a good alternative for screening FD in women with CKD. A thorough medical evaluation is required to determine the pathogenicity of variants in these patients.
Zazen: A Mediating SOA between Ajax Applications and Enterprise Data (2008)

One reason that enterprises are adopting service-oriented architectures (SOA) is to develop applications more quickly by packaging - and then reusing - applications and data assets as services. Service encapsulation of implementation details is an important feature, and contributes to the loosely-coupled nature of a SOA. From this perspective, SOA data-services seem incompatible with AJAX frameworks which presume a great degree of client-side control of an application's data. For their part, AJAX frameworks promise to increase web-application performance by reducing the number of interactions between the browser and server. Caching server data on the web-client is a well known technique for achieving this goal, but implies that enterprise data is exposed to client-side developers. This paper presents ZAZEN, a SOA that mediates between the need to encapsulate enterprise data as a service and the needs of AJAX developers who want more control of their application's data. We describe ZAZEN's server-side architecture and discuss two APIs to the data-service: a REST API, and an implementation of the DOJO data APIs for relational databases.
In Situ Measurements of Solid Electrolyte Interphase Evolution on Silicon Electrodes (2016)

We report in situ measurements of initial solid electrolyte interphase (SEI) evolution on silicon negative electrode and also the lithiation-induced silicon volume changes in lithium ion half-cells. Thin film amorphous silicon ( a -Si) electrodes are designed to enable unambiguous measurement of SEI thickness evolution and silicon thickness evolution. The thin film electrode samples are assembled into a custom-designed electrochemical cell integrated with an atomic force microscope (AFM) to facilitate real time measurements. The films are subjected to two potentiostatic lithiation and delithiation cycles by applying a series of constant potential values against lithium metal, which serves as the counter and reference electrode. The thickness changes are measured after a state of equilibrium is reached at each potential value. Experiments are carried out with two electrolytes – 1.2M lithium hexafluoro-phosphate (LiPF 6 ) in ethylene carbonate (EC) and 1.2M LiPF 6 in propylene carbonate (PC) – to investigate the influence of electrolyte compositions on SEI formation and electrochemical performance. The results reveal that the predominant SEI thickness evolution occurs during the first cycle, and reaches steady values of approximately 17nm with EC electrolyte and 10nm with PC electrolyte. Despite the thinner SEI layer, capacity loss due to SEI formation is larger with PC electrolyte compared to that of EC electrolyte. Si volume change shows approximately 21% of irreversible volume expansion during the first cycle and no appreciable irreversible volume expansion was observed in the subsequent cycle. In addition, silicon volume expansion shows an approximate linear relationship with the state of charge. Volume change and capacity of silicon films show hysteresis as functions of equilibrium potential. We seek to explain such hysteretic behavior in terms of the stress-potential coupling in silicon, which shows both qualitative and quantitative agreement. Beyond the specific materials systems considered here, the in situ AFM based experimental technique developed in this work has broader applications to investigate the role of electrolyte composition in the SEI formation kinetics. Figure 1
Delayed-Immediate Breast Reconstruction: Technical and Timing Considerations (2010)

Delayed-immediate reconstruction allows patients who do not require postmastectomy radiation therapy to receive the benefits of skin-sparing mastectomy with aesthetic outcomes similar to those of immediate reconstruction. Patients who do require radiation receive a skin-preserving delayed reconstruction, while avoiding the problems that can be associated with radiation delivery after an immediate breast reconstruction.
Improved Methanol Oxidation Activity Through Oxidation-Induced Phase Separation of PtRu Electrocatalysts (2000)

Abstract Direct methanol fuel cells (DMFCs) offer a simpler, safer technology for point-of-use power sources compared to other hydrogen fuel cells, by avoiding the need to store hydrogen fuel or to carry out the reformation of hydrocarbons. The direct methanol oxidation electrocatalyst of choice is a nanoscale black consisting of a 50:50 atom % mixture of Pt and Ru. It has recently become known that these presumed bimetallic alloys in fact contain an array of metal, oxide and hydrous phases, which are easily misidentified in routine x-ray diffraction measurements due to particle size-broadening and poor crystallinity. By combining transmission electron microscopy, electrochemistry and thermogravimetric studies, we demonstrate here that the route to improved catalytic activity is not by phase purification of the bimetallic alloys, but instead phase engineering of hydrous ruthenium oxide and Pt mixtures.
Fast time-to-market with via-configurable transistor array regular fabric: A delay-locked loop design case study (2011)

Time-to-market is a critical issue for nowadays integrated circuits manufacturers. In this paper the Via-Configurable Transistor Array regular layout fabric (VCTA), which aims to minimize the time-to-market and its associated costs, is studied for a Delay-Locked Loop design (DLL). The comparison with a full custom design demonstrates that VCTA can be used without loss of functionality while accelerating the design time. Layout implementations, in 90 nm CMOS process, as well as the delay, energy and jitter electrical simulations are provided.
Efficacy Study of Novel Diamidine Compounds in a Trypanosoma evansi Goat Model (2020)

Three diamidines (DB 75, DB 867 and DB 1192) were selected and their ability to cure T. evansi experimentally infected goats was investigated. A toxicity assessment and pharmacokinetic analysis of these compounds were additionally carried out. Goats demonstrated no signs of acute toxicity, when treated with four doses of 1 mg/kg/day (total dose 4 mg/kg). Complete curative efficacy of experimentally infected goats was seen in the positive control group treated with diminazene at 5 mg/kg and in the DB 75 and DB 867 groups treated at 2.5 mg/kg. Drug treatment was administered once every second day for a total of seven days. Complete cure was also seen in the group of goats treated with DB 75 at 1.25 mg/kg. DB 1192 was incapable of curing goats at either four-times 2.5 mg/kg or 1.25 mg/kg. Pharmacokinetic analysis clearly demonstrated that the treatment failures of DB 1192 were due to sub-therapeutic compound levels in goat plasma, whilst compound levels for DB 75 and DB 867 remained well within the therapeutic window. In conclusion, two diamidine compounds (DB 75 and DB 867) presented comparable efficacy at lower doses than the standard drug diminazene and could be considered as potential clinical candidates against T. evansi infection.
Longevity effect of a polysaccharide from Chlorophytum borivilianum on Caenorhabditis elegans and Saccharomyces cerevisiae (2017)

The traditional Indian medicine, Ayurveda, provides insights and practical solutions towards a healthy life style. Rasayana is a branch of Ayurveda known for preserving and promoting health, enhancing the quality of life and delaying the aging process. In the traditional knowledge, the Rasayana herb, Chlorophytum borivilianum (C. borivilanum) is regarded as a general health promoting tonic that delays aging and increases lifespan, cognitive function and physical strength. Aging is a complex and multifactorial physiological phenomenon that manifests itself over a wide range of biological systems, tissues, and functions. Longevity is an obvious marker of physiological aging. Simple model systems such as the single-cell budding yeast Saccharomyces cerevisiae (S. cerevisiae) and the nematode, Caenorhabditis elegans (C. elegans) are widely used to study the aging process and longevity. Here, we show that a polysaccharide fraction obtained from C. borivilianum increases the lifespan of S. cerevisiae and C. elegans, using an automated screening platform (ChronoscreenTM). Chemical analysis of this extract revealed a low molecular weight polysaccharide of 1000 Da, predominantly comprising Glu1→6Glu linkage. This polysaccharide showed significant dose-dependent extension of the median lifespan of S. cerevisiae by up to 41% and of the median lifespan of C. elegans by up to 10%. Taking cue from these results and the traditionally described benefits of Rasayanas on skin rejuvenation, we tested in vitro the polysaccharide for potential skin benefits. In a keratinocyte culture, we observed that this polysaccharide increased cell proliferation significantly, and induced synthesis of hyaluronic acid (HA), a well-known extracellular matrix component. Furthermore, when added to culture medium of human reconstructed epidermis, we observed an enhanced production of epidermal markers, e.g. CD44 and HA that are otherwise diminished in aged skin. Together, these results suggest that in addition to life-span extension of S. cerevisiae and C. elegans, a polysaccharide from the Rasayana herb, C. borivilianum may have beneficial effects on skin aging parameters.
Recovery of Clostridium thermosulfurogenes Produced β‐Amylase by (Hydroxypropyl)methylcellulose Partition (1990)

A procedure for recovering Clostridium thermosulfurogenes produced beta-amylase from fermentation broth by partition was developed. The partition was achieved by addition of ammonium sulfate to an aqueous solution of the enzyme with (hydroxypropyl)methylcellulose. The beta-amylase-containing pellet formed upon centrifugation could be redissolved and the polymer recovered by a second salt addition. The process was not dependent on polymer/enzyme solution pH, but it was affected by temperature, polymer nominal molecular weight and loading, and fermentation carbon source. Unlike more traditional aqueous-phase partitions, such as poly(ethylene glycol)/dextran, the current approach appeared to be biospecific.
Image representation by group theoretic approach (1991)

A group theoretic approach to image representation and analysis by means of wavelet-type transforms is presented. The following special cases of interest in image representation and in biological and computer vision are discussed: 2- and 3-D rigid motion; similarities; and 2-D projective group obtained from 3-D camera rotation followed by the group of planar translation.
Peritoneal macrophage depletion by liposomal bisphosphonate attenuates endometriosis in the rat model (2008)

Macrophage depletion using IP LA has been shown to effectively inhibit the initiation and growth of EM implants, in a rat EM model. The clear dose-response effect may be viewed as a confirmation of the validity of the concept and encourages further study.
Re: Activation of HIF2α in Kidney Proximal Tubule Cells Causes Abnormal Glycogen Deposition but Not Tumorigenesis (2013)

No AccessJournal of UrologyInvestigative Urology1 Feb 2014Re: Activation of HIF2α in Kidney Proximal Tubule Cells Causes Abnormal Glycogen Deposition but Not Tumorigenesis Anthony AtalaMD Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.10.083AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Activation of HIF2α in Kidney Proximal Tubule Cells Causes Abnormal Glycogen Deposition but Not Tumorigenesis." The Journal of Urology, 191(2), p. 555 © 2014 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 191Issue 2February 2014Page: 555Supplementary Materials Advertisement Copyright & Permissions© 2014 by American Urological Association Education and Research, Inc.Metrics Author Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...