gebhart/patrepeval huggingface dataset:
Dual-channel red/blue fluorescence dosimetry with broadband reflectance spectroscopic correction measures protoporphyrin IX production during photodynamic therapy of actinic keratosis (2014)

Dosimetry for aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) photodynamic therapy of actinic keratosis was examined with an optimized fluorescence dosimeter to measure PpIX during treatment. While insufficient PpIX generation may be an indicator of incomplete response, there exists no standardized method to quantitate PpIX production at depths in the skin during clinical treatments. In this study, a spectrometer-based point probe dosimeter system was used to sample PpIX fluorescence from superficial (blue wavelength excitation) and deeper (red wavelength excitation) tissue layers. Broadband white light spectroscopy (WLS) was used to monitor aspects of vascular physiology and inform a correction of fluorescence for the background optical properties. Measurements in tissue phantoms showed accurate recovery of blood volume fraction and reduced scattering coefficient from WLS, and a linear response of PpIX fluorescence versus concentration down to 1.95 and 250 nM for blue and red excitations, respectively. A pilot clinical study of 19 patients receiving 1-h ALA incubation before treatment showed high intrinsic variance in PpIX fluorescence with a standard deviation/mean ratio of > 0.9. PpIX fluorescence was significantly higher in patients reporting higher pain levels on a visual analog scale. These pilot data suggest that patient-specific PpIX quantitation may predict outcome response.
Food allergy and headlice update (2004)

There has been much confusion in recent years regarding the terminology used to describe allergic reactions, particularly food reactions. The World Allergy Organisation Nomenclature Review Committee has proposed the following nomenclature. The term food hypersensitivity is used to describe any adverse reaction to a food and encompasses the two distinctly different pathologies of: Food allergy. Food allergy is defined as a reaction that is due to an immunological mechanism and can be further characterised as IgE (allergy antibody) mediated or non-IgE mediated. Food intolerance. Food intolerance, in contrast, is a hypersensitivity that is non immunologically mediated. It may occur as a result of factors present in the food such as toxins (eg. histamine in scromboid fish poisoning) or pharmacologic (eg. tyramine in cheeses or red wine). These reactions can occur in most subjects when given in high enough doses. Alternatively, food intolerance may occur as a result of a metabolic disorder (eg. lactase deficiency resulting in lactose intolerance).  ---------------------- This update on headlice aims to support health professionals in their work with parents and families who are trying to manage infestations.
“Getting from Here to There”-Mechanisms and Limitations to the Activation of the Androgen Receptor in Castration-Resistant Prostate Cancer (2010)

Despite the clinical regression that typifies the initial response of advanced prostate cancer to gonadal testosterone depletion, tumors eventually progress. However, evidence supports the concept that signaling via the androgen receptor (AR) is important in progression to castration-resistant prostate cancer (CRPC). Steroid hormones are synthesized from cholesterol in a series of tightly regulated steps involving the cleavage of carbon-carbon bonds, the introduction of functional groups derived from activated molecular oxygen, and the oxidation and reduction of carbon-carbon and carbon-oxygen bonds. In the adrenal cortex and gonads, steroidogenesis is tightly regulated, very efficient, and highly directional. In contrast, steroid metabolism in peripheral tissues is characterized by competing enzymes and pathways, low efficiency, and great variability. Many steps are mechanistically and functionally irreversible, but some are not, and the repertoire of specific enzymes, intracellular redox state, and access to hormone precursors all contribute to steroid flux and accumulation. The investigation of steroid metabolizing enzymes in CRPC often assumes that the pathways and the patterns of metabolism mirror those defined in the adrenals and the gonads and validated by human deficiency syndromes. Unfortunately, several potential pathways using different enzymes might contribute substantially to androgen synthesis in CRPC. Finally, a number of mechanisms have been reported by which the AR is activated independent of ligand. Recent observations have suggested that AR forms with constitutive activity occur in CRPC, stimulating transcription without a requirement for ligand. This overview outlines a broad view of how the mechanisms by which the AR may be activated, whether by alternate pathways of androgen synthesis or the production of alternate forms of the AR, with an emphasis on what aspects must be accounted for when using model systems to explore the biology of human prostate cancer.
Effect of High Density Lipoproteins on Protein Expression in Myoblast Cell Lines (2005)

We have studied the effects of high-density lipoprotein (HDL) on rat heart (H9c2) and skeletal (L6) myoblasts using two-dimensional gel electrophoresis and tandem mass spectrometry. Gels generated from control cells and cells treated with 250 microg/mL HDL showed significant differences in the 7-10 pI region and the 30-50 kDa mass region. In particular, the membrane binding protein, annexin II, the voltage-dependent anion channel, glyceraldehyde-3-phosphate dehydrogenase and other glycolytic proteins are differentially expressed.
In-network Neural Networks (2018)

We present N2Net, a system that implements binary neural networks using commodity switching chips deployed in network switches and routers. Our system shows that these devices can run simple neural network models, whose input is encoded in the network packets' header, at packet processing speeds (billions of packets per second). Furthermore, our experience highlights that switching chips could support even more complex models, provided that some minor and cheap modifications to the chip's design are applied. We believe N2Net provides an interesting building block for future end-to-end networked systems.
Measurement and modeling of interference for multiple antenna system (2010)

Abstract This article provides a detailed signal model (DSM) based on network theory to predict the multiantenna capacity in the presence of co‐ and adjacent channel interference.This model expands on previous channel models by including the simultaneous effects of interference, antenna matching, efficiency, directivity and polarization. Single and multiantenna interference are modeled using both a statistical channel model and a site‐specific 3D ray tracer. The network theory based DSM was obtained by adding antenna front end effects at both the transmitter and receiver to the channel models. This model was validated with measurements performed in two underground tunnels. The site‐specific model predicted the capacity to within 1 bit/sec/Hz of the measurements while the statistical model was within 1‐2 bits/sec/Hz except for a few locations. It was also observed that for small antenna spacing the conjugate match provides higher capacity than the self match. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 2031–2037, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25367
Light‐Driven ZnO Brush‐Shaped Self‐Propelled Micromachines for Nitroaromatic Explosives Decomposition (2019)

Self-propelled micromachines have recently attracted lots of attention for environmental remediation. Developing a large-scale but template-free fabrication of self-propelled rod/tubular micro/nanomotors is very crucial but still challenging. Here, a new strategy based on vertically aligned ZnO arrays is employed for the large-scale and template-free fabrication of self-propelled ZnO-based micromotors with H<sub>2</sub> O<sub>2</sub> -free light-driven propulsion ability. Brush-shaped ZnO-based micromotors with different diameters and lengths are fully studied, which present a fast response to multicycles UV light on/off switches with different interval times (2/5 s) in pure water and slow directional motion in aqueous hydrogen peroxide solution in the absence of UV light. Light-induced electrophoretic and self-diffusiophoretic effects are responsible for these two different self-motion behaviors under different conditions, respectively. In addition, the pH of the media and the presence of H<sub>2</sub> O<sub>2</sub> show important effects on the motion behavior and microstructure of the ZnO-based micromotors. Finally, these novel ZnO-based brush-shaped micromotors are demonstrated in a proof-of-concept study on nitroaromatic explosive degradation, i.e., picric acid. This work opens a completely new avenue for the template-free fabrication of brush-shaped light-responsive micromotors on a large scale based on vertically aligned ZnO arrays.
Intrazeolite half-sandwich complexes of rhodium and iridium: spectroscopy and reactivity patterns (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntrazeolite half-sandwich complexes of rhodium and iridium: spectroscopy and reactivity patternsGeoffrey A. Ozin, David M. Haddleton, and Caroline J. GilCite this: J. Phys. Chem. 1989, 93, 18, 6710–6719Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://doi.org/10.1021/j100355a029RIGHTS & PERMISSIONSArticle Views104Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Supporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Java TM just-in-time compiler and virtual machine improvements for server and middleware applications (2004)

This paper describes optimization techniques recently applied to the Just-In-Time compilers that are part of the IBM® Developer Kit for JavaTM and the J9 Java virtual machine specification. It focusses primarily on those optimizations that improved server and middleware performance. Large server and middleware applications written in the Java programming language present a variety of performance challenges to virtual machines (VMs) and justin-time (JIT) compilers; we must address not only steady-state performance but also start-up time. In this paper, we describe 12 optimizations that have been implemented in IBM products because they improve the performance and scalability of these types of applications. These optimizations reduce, for example, the overhead of synchronization, object allocation, and some commonly used Java class library calls. We also describe techniques to address server start-up time, such as recompilation strategies. The experimental results show that the optimizations we discuss in this paper improve the performance of applications such as SPECjbb2000 and SPECjAppServer2002 by as much as 10-15%.
Thermal Nonlinearities in Contour Mode AlN Resonators (2013)

In this paper, we analyze the origin of elastic nonlinearities in aluminium nitride contour mode resonators (CMRs). Our study highlights that the nonlinear behavior is due to thermal effects when the resonators are electrically excited and the input is slowly (slow with respect to the device thermal time constant) swept through the excitation frequencies close to the main resonance. An analytical expression that relates the nonlinear behavior of the device to its geometry and material properties is derived. Amplitude-frequency (A-f) and third-order intermodulation (IMD3) measurements on 1-GHz AlN CMRs are employed to demonstrate the theoretical reasoning. The two experiments confirm the validity of the analytical derivation when the system is dominated by thermally induced nonlinearities. In the case of large frequency difference between the modulation frequencies, purely elastic nonlinearity can also be extracted from the IMD3 measurements.
A detailed study of attached and separated compression corner flowfields in high Reynolds number supersonic flow (1978)

An experimental study has been carried out to detail the interaction of a compressible turbulent boundary layer with shock waves of varying strengths. The interaction was produced by two-dimensional compression corners of 8, 16, 20, and 24 deg angles. The incoming boundary layer had an edge Mach number of 2.85 and a Reynolds number of 1.7 million based on overall thickness. Detailed mean-flow and surface measurements are presented for the four corner angles. The 8 deg corner flow was found to be fully attached, while the 16 deg case was near incipient separation. Both the 20 deg and 24 deg corners produced significant flow separation regions. In the discussion of these results, emphasis is placed on the development of flowfield properties from attached to separated conditions. Comparisons made with a computational solution of the Navier-Stokes equations show good agreement when the corner flow is not separated.
Coulometry‐assisted quantitation in spray ionization mass spectrometry (2020)

The concentration of target analyte in a mixture can be quantified by combining coulometric measurements with spray ionization mass spectrometry. A three-electrode system screen printed on the polymer support acts both as the coulometry platform for electrochemical oxidation and the sample loading tip for spray ionization. After loading a droplet of the analyte solution onto the tip, two steps were taken to implement quantitation. First, the electrochemical oxidation potential was optimized with cyclic voltammetry followed by coulometric measurements to calculate the amount of oxidized analyte under a constant low voltage within a fixed period of time (5 s). Then, a high voltage (+4.5 kV) was applied to the tip to trigger spray ionization for measuring the oxidation yield from the native analyte ion and its oxidized product ion intensities by mass spectrometry. The analyte's native concentration is quantified by dividing the oxidized product's concentration (based on Coulomb's law) and the oxidation yield (estimated from mass spectrometry [MS] assuming that the parent and oxidation product have nearly the same ionization efficiencies). The workflow has an advantage in being free of any standard for constructing the quantitation curve. Several model compounds (tyrosine, dopamine, and angiotensin II) were selected for method validation. It was demonstrated that this strategy was feasible with an accuracy of ~15% for a wide coverage of different species including endogenous metabolites and peptides. As an example of its possible practical use, it was initially employed to make a bilirubin assay in urine.
Topological Considerations for the Design of Molecular Donors with Multiple Absorbing Units (2014)

The molecule AT1, with two weakly conjugated chromophores, was designed, synthesized, and examined within the context of its film forming tendencies. While the addition of the second chromophore to the central core enables broadening of the absorption spectrum, this change is mostly apparent in films that are grown slowly. Grazing incidence X-ray scattering (GIWAXS) analysis indicates that these spectral characteristics correspond to an increase in solid state ordering. This information, in combination with differential scanning calorimetry, suggests that the overall molecular shape provides a kinetic barrier to crystallization. As a result, one finds the absence of molecular order when AT1 is combined with PC71BM in solution-cast blends. These findings highlight the importance of molecular topology when designing molecular components for solar cell devices.
Paracyclophene Route to Poly(p-phenylenevinylene) (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTParacyclophene Route to Poly(p-phenylenevinylene)Yi-Jun Miao and Guillermo C. BazanCite this: J. Am. Chem. Soc. 1994, 116, 20, 9379–9380Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://doi.org/10.1021/ja00099a085RIGHTS & PERMISSIONSArticle Views353Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (244 KB) Get e-AlertsSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Inhibition of renal caveolin-1 reduces natriuresis and produces hypertension in sodium-loaded rats (2011)

Renal dopamine receptor function and ion transport inhibition are impaired in essential hypertension. We recently reported that caveolin-1 (CAV1) and lipid rafts are necessary for normal D(1)-like receptor-dependent internalization of Na-K-ATPase in human proximal tubule cells. We now hypothesize that CAV1 is necessary for the regulation of urine sodium (Na(+)) excretion (U(Na)V) and mean arterial blood pressure (MAP) in vivo. Acute renal interstitial (RI) infusion into Sprague-Dawley rats of 1 μg·kg⁻¹·min⁻¹ fenoldopam (FEN; D(1)-like receptor agonist) caused a 0.46 ± 0.15-μmol/min increase in U(Na)V (over baseline of 0.29 ± 0.04 μmol/min; P < 0.01). This increase was seen in Na(+)-loaded rats, but not in those under a normal-sodium load. Coinfusion with β-methyl cyclodextrin (βMCD; lipid raft disrupter, 200 μg·kg⁻¹·min⁻¹) completely blocked this FEN-induced natriuresis (P < 0.001). Long-term (3 day) lipid raft disruption via continuous RI infusion of 80 μg·kg⁻¹·min⁻¹ βMCD decreased renal cortical CAV1 expression (47.3 ± 6.4%; P < 0.01) and increased MAP (32.4 ± 6.6 mmHg; P < 0.001) compared with vehicle-infused animals. To determine whether the MAP rise was due to a CAV1-dependent lipid raft-mediated disruption, Na(+)-loaded rats were given a bolus RI infusion of CAV1 siRNA. Two days postinfusion, cortical CAV1 expression was decreased by 73.6 ± 8.2% (P < 0.001) and the animals showed an increase in MAP by 17.4 ± 2.9 mmHg (P < 0.01) compared with animals receiving scrambled control siRNA. In summary, acute kidney-specific lipid raft disruption decreases CAV1 expression and blocks D(1)-like receptor-induced natriuresis. Furthermore, chronic disruption of lipid rafts or CAV1 protein expression in the kidney induces hypertension.
Flat-Profile Tape–Head Friction and Magnetic Spacing (2013)

The friction and magnetic spacing between magnetic tape and a recording head are measured as a function of the wrap angle at several tape speeds and tape tensions for two tape samples with different roughnesses. An increase in friction and a decrease in magnetic spacing are measured for: 1) increasing wrap angle; 2) decreasing tape speed; and 3) increasing tape tension. The relation between the magnetic spacing and friction is fixed when varying the tape tension or wrap angle. For the rougher tape sample, reducing the tape speed (and adjusting the tape tension and wrap angle accordingly) reduces the magnetic spacing without increasing the friction. Although the smoother tape experiences more friction for a fixed wrap angle and tape tension, a smaller magnetic spacing at a specified friction is measured for it than for the rougher tape.
High-power considerations in metamaterial antennas (2014)

While many studies have been conducted on metamaterials at microwave frequencies, comparatively few have examined their use in high-power applications. Here, we perform a general study of metamaterial geometries to identify configurations that are well-suited for utilization in high-power environments. We further develop a genetic algorithm optimization scheme for synthesizing pixelized geometries with artificial magnetic conducting (AMC) properties and reduced maximum field enhancement factor (MFEF).
Efficient binaural rendering of spherical microphone array data by linear filtering (2021)

Abstract High-quality rendering of spatial sound fields in real-time is becoming increasingly important with the steadily growing interest in virtual and augmented reality technologies. Typically, a spherical microphone array (SMA) is used to capture a spatial sound field. The captured sound field can be reproduced over headphones in real-time using binaural rendering, virtually placing a single listener in the sound field. Common methods for binaural rendering first spatially encode the sound field by transforming it to the spherical harmonics domain and then decode the sound field binaurally by combining it with head-related transfer functions (HRTFs). However, these rendering methods are computationally demanding, especially for high-order SMAs, and require implementing quite sophisticated real-time signal processing. This paper presents a computationally more efficient method for real-time binaural rendering of SMA signals by linear filtering. The proposed method allows representing any common rendering chain as a set of precomputed finite impulse response filters, which are then applied to the SMA signals in real-time using fast convolution to produce the binaural signals. Results of the technical evaluation show that the presented approach is equivalent to conventional rendering methods while being computationally less demanding and easier to implement using any real-time convolution system. However, the lower computational complexity goes along with lower flexibility. On the one hand, encoding and decoding are no longer decoupled, and on the other hand, sound field transformations in the SH domain can no longer be performed. Consequently, in the proposed method, a filter set must be precomputed and stored for each possible head orientation of the listener, leading to higher memory requirements than the conventional methods. As such, the approach is particularly well suited for efficient real-time binaural rendering of SMA signals in a fixed setup where usually a limited range of head orientations is sufficient, such as live concert streaming or VR teleconferencing.
ChemInform Abstract: Solution Synthesis of Nanoparticular Binary Transition Metal Antimonides. (2011)

Abstract The transition metal antimonides MSb with M: Co, Ni, and Zn and Cu 2 Sb with particle sizes ranging from 20 to 60 nm are prepared using presynthesized antimony nanoparticles and activated metal nanoparticles as precursors.