gebhart/patrepeval huggingface dataset:
The Caenorhabditis elegans Cathepsin Z-like Cysteine Protease, Ce-CPZ-1, Has a Multifunctional Role during the Worms' Development (2004)

We have analyzed the expression and function of Cecpz-1, a Caenorhabditis elegans cathepsin Z-like cysteine protease gene, during development of the worm. The cpz-1 gene is expressed in various hypodermal cells of all developmental stages and is specifically expressed in the gonads and the pharynx of adult worms. Disruption of cpz-1 function by RNA interference or cpz-1(ok497) deletion mutant suggests that cpz-1 has a role in the molting pathways. The presence of the native CPZ-1 protein in the hypodermis/cuticle of larval and adult stages and along the length of the pharynx of adult worms, as well as the cyclic expression of the transcript during larval development, supports such function. We hypothesize that the CPZ-1 enzyme functions directly as a proteolytic enzyme degrading cuticular proteins before ecdysis and/or indirectly by processing other proteins such as proenzymes and/or other proteins that have an essential role during molting. Notably, an impressive level of the CPZ-1 native protein is present in both the new and the old cuticles during larval molting, in particular in the regions that are degraded prior to shedding and ecdysis. The similar localization of the related Onchocerca volvulus cathepsin Z protein suggests that the function of CPZ-1 during molting might be conserved in other nematodes. Based on the cpz-1 RNA interference and cpz-1 (ok497) deletion mutant phenotypes, it appears that cpz-1 have additional roles during morphogenesis. Deletion of cpz-1 coding sequence or inhibition of cpz-1 function by RNA interference also caused morphological defects in the head or tail region of larvae, improperly developed gonad in adult worms and embryonic lethality. The CPZ-1 native protein in these affected regions may have a role in the cuticular and the basement membrane extracellular matrix assembly process. The present findings have defined a critical role for cathepsin Z in nematode biology.
ChemInform Abstract: POTENTIAL ANTITUMOR AGENTS. 25. AZALOGS OF THE 4′‐(9‐ACRIDINYLAMINO)METHANESULFONANILIDES (1978)

Abstract 2‐Chlorbenzoesäure (I) kondensiert mit 3‐Amino‐pyridin (II) zur Pyridylamino‐benzoesäure (III), die mit Polyphosphorsäure zu (IV) cyclisiert und mit Thionylchlorid in (V) übergeführt wird.
Supplementary Tables 1-3, Figures 1-6 from PME-1 Protects Extracellular Signal-Regulated Kinase Pathway Activity from Protein Phosphatase 2A–Mediated Inactivation in Human Malignant Glioma (2023)

Supplementary Tables 1-3, Figures 1-6 from PME-1 Protects Extracellular Signal-Regulated Kinase Pathway Activity from Protein Phosphatase 2A–Mediated Inactivation in Human Malignant Glioma
Coralyne. Intercalation with DNA as a possible mechanism of antileukemic action (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoralyne. Intercalation with DNA as a possible mechanism of antileukemic actionW. David Wilson, Alice N. Gough, James J. Doyle, and Michael W. DavidsonCite this: J. Med. Chem. 1976, 19, 10, 1261–1263Publication Date (Print):October 1, 1976Publication History Published online1 May 2002Published inissue 1 October 1976https://pubs.acs.org/doi/10.1021/jm00232a020https://doi.org/10.1021/jm00232a020research-articleACS PublicationsRequest reuse permissionsArticle Views412Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Competing Indentation Deformation Mechanisms in Glass Using Different Strengthening Methods (2016)

Chemical strengthening via ion exchange, thermal tempering, and lamination are proven techniques for the strengthening of oxide glasses. For each of these techniques, the strengthening mechanism is conventionally ascribed to the linear superposition of the compressive stress (CS) profile on the glass surface. However, in this work, we use molecular dynamics simulations to reveal the underlying indentation deformation mechanism beyond the simple linear superposition of compressive and indentation stresses. In particular, the plastic zone can be dramatically different from the commonly assumed hemispherical shape, which leads to a completely different stress field and resulting crack system. We show that the indentation-induced fracture is controlled by two competing mechanisms: the CS itself and a potential reduction in free volume that can increase the driving force for crack formation. Chemical strengthening via ion exchange tends to escalate the competition between these two effects, while thermal tempering tends to reduce it. Lamination of glasses with differential thermal expansion falls in between.
Face Card: An Information-sharing Framework on Google Glass (2016)

Wearable devices such as Google Glass can provide an efficient way to get around users information. We present Face Card, a system builds on Google Glass to provide information-sharing service with around people. With a look at Google Glass, users can quickly get information of nearby and coming users. Utilizing Bluetooth Low Energy (BLE) and proper user interface, Face Card demonstrates the potential of being an efficient information sharing system framework.
Demonstrating an absolute quantum advantage in direct absorption measurement (2017)

Engineering apparatus that harness quantum theory promises to offer practical advantages over current technology. A fundamentally more powerful prospect is that such quantum technologies could out-perform any future iteration of their classical counterparts, no matter how well the attributes of those classical strategies can be improved. Here, for optical direct absorption measurement, we experimentally demonstrate such an instance of an absolute advantage per photon probe that is exposed to the absorbative sample. We use correlated intensity measurements of spontaneous parametric downconversion using a commercially available air-cooled CCD, a new estimator for data analysis and a high heralding efficiency photon-pair source. We show this enables improvement in the precision of measurement, per photon probe, beyond what is achievable with an ideal coherent state (a perfect laser) detected with 100% efficient and noiseless detection. We see this absolute improvement for up to 50% absorption, with a maximum observed factor of improvement of 1.46. This equates to around 32% reduction in the total number of photons traversing an optical sample, compared to any future direct optical absorption measurement using classical light.
Noisy Network Coding (2010)

A noisy network coding scheme for sending multiple sources over a general noisy network is presented. For multi-source multicast networks, the scheme naturally extends both network coding over noiseless networks by Ahlswede, Cai, Li, and Yeung, and compress-forward coding for the relay channel by Cover and El Gamal to general discrete memoryless and Gaussian networks. The scheme also recovers as special cases the results on coding for wireless relay networks and deterministic networks by Avestimehr, Diggavi, and Tse, and coding for wireless erasure networks by Dana, Gowaikar, Palanki, Hassibi, and Effros. The scheme involves message repetition coding, relay signal compression, and simultaneous decoding. Unlike previous compress--forward schemes, where independent messages are sent over multiple blocks, the same message is sent multiple times using independent codebooks as in the network coding scheme for cyclic networks. Furthermore, the relays do not use Wyner--Ziv binning as in previous compress-forward schemes, and each decoder performs simultaneous joint typicality decoding on the received signals from all the blocks without explicitly decoding the compression indices. A consequence of this new scheme is that achievability is proved simply and more generally without resorting to time expansion to extend results for acyclic networks to networks with cycles. The noisy network coding scheme is then extended to general multi-source networks by combining it with decoding techniques for interference channels. For the Gaussian multicast network, noisy network coding improves the previously established gap to the cutset bound. We also demonstrate through two popular AWGN network examples that noisy network coding can outperform conventional compress-forward, amplify-forward, and hash-forward schemes.
Olefin Autoxidation in Flow (2014)

Handling hazardous multiphase reactions in flow brings not only safety advantages but also significantly improved performance, due to better mass transfer characteristics. In this paper, we present a continuous microreactor setup, capable of performing olefin autoxidations with O2, under solvent-free and catalyst-free conditions. Owing to the transparent reactor design, consumption of O2 can be visually followed and exhaustion of the gas bubbles marks a clear end point along the channel length coordinate. Tracking the position of this end point enables measuring effective rate constants. The developed system was calibrated using the well-studied β-pinene substrate, and was subsequently applied to the synthetically interesting transformation of (+)-valencene to (+)-nootkatone. For the latter, a space-time yield was obtained that is at least 3 orders of magnitude larger than that realized with established biotechnology approaches.
Editorial Comment (2006)

No AccessJournal of UrologyAdult urology1 Oct 2006Editorial Comment Jacob Rajfer Jacob RajferJacob Rajfer More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2006.06.156AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 176(4), pp. 1527–1528 Division of Urology, Harbor UCLA Medical Center, Torrance, California© 2005 by American Urological AssociationFiguresReferencesRelatedDetails Volume 176Issue 4October 2006Page: 1527-1528 Advertisement Copyright & Permissions© 2005 by American Urological AssociationMetricsAuthor Information Jacob Rajfer More articles by this author Expand All Advertisement PDF DownloadLoading ...
Abstract 14125: An in vitro Pulmonary Vascular Platform From Endothelialized Whole Lung Scaffolds (2020)

Introduction: The development of an in vitro system is critical to studying human diseases including the novel coronavirus disease-19 (COVID-19), and is typically centered on recapitulating native physiology. In the case of the pulmonary vasculature, the endothelium is critical for establishing the fluid-tight barrier in the alveolar compartment, and displays significant phenotypic and functional heterogeneity along vascular tree. Objective: Here, we developed an experimental platform that could mimic physiological functions and cellular phenotypes of pulmonary vasculature, during homeostatic and diseased states. Methods and Results: Lymphatic low pulmonary microvascular endothelial cells (Lymph low PMECs) were isolated from Prox1-GFP rodent lungs from regions of having low amounts of lymphatic tissue. Single-cell RNA-sequencing (scRNAseq) data revealed that these cells were becoming phenotypically homogenous over several passages while losing some markers of native differentiation during passaging. Intriguingly, after culturing in decellularized lung scaffolds, the phenotype of the lymph low PMEC changed back toward native lung endothelium. Vascular barrier function was partially restored in engineered lungs repopulated with endothelium, while small capillaries with patent lumens were appreciable. To evaluate the ability of the engineered endothelium to modulate permeability in response to exogenous stimuli, lipopolysaccharide (LPS) was introduced into repopulated lungs to simulate acute lung injury. After LPS treatment, the pro-inflammatory signal was significantly increased and the vascular barrier was severely impaired in the repopulated lung. Conclusions: Taken together, these results show a novel platform that recapitulates some pulmonary microvascular functions and phenotypes at a whole organ level. This development may help pave the way for using the whole organ engineering approach to model vascular diseases.
Measurement of the ratio of the vector to pseudoscalar charm semileptonic decay rate Γ(D+→K¯*0μ+νμ)/Γ(D+→K¯0μ+νμ) (2004)

Using a high statistics sample of photo-produced charm particles from the FOCUS experiment at Fermilab, we report on the measurement of the ratio of semileptonic rates Γ(D+→Kπμ+νμ)/Γ(D+→K¯0μ+νμ)=0.625±0.045±0.034. Allowing for the Kπ S-wave interference measured in [J.M. Link, et al., FOCUS Collaboration, Phys. Lett. B 544 (2002) 89], we extract the vector to pseudoscalar ratio Γ(D+→K¯*0μ+νμ)/Γ(D+→K¯0μ+νμ)=0.594±0.043±0.033 and the ratio Γ(D+→K¯0μ+νμ)/Γ(D+→K−π+π+)=1.019±0.076±0.065. Our results show a lower ratio for Γ(D→K*ℓν)/Γ(D→Kℓν) than has been reported recently and indicate the current world average branching fractions for the decays D+→K¯0(μ+,e+)νμ,e are low. Using the world average B(D+→K−π+π+) [K. Hagiwara, et al., Particle Data Group Collaboration, Phys. Rev. D 66 (2002) 010001, and 2003 partial update for edition 2004 (http://pdg.lbl.gov)] we extract B(D+→K¯0μ+ν)=(9.27±0.69±0.59±0.61)%.
Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals (2019)

Avian influenza viruses (AIVs) must acquire mammalian-adaptive mutations before they can efficiently replicate in and transmit among humans. The PB2 E627K mutation is known to play a prominent role in the mammalian adaptation of AIVs. The H7N9 AIVs that emerged in 2013 in China easily acquired the PB2 E627K mutation upon replication in humans. Here, we generate a series of reassortant or mutant H7N9 AIVs and test them in mice. We show that the low polymerase activity attributed to the viral PA protein is the intrinsic driving force behind the emergence of PB2 E627K during H7N9 AIV replication in mice. Four residues in the N-terminal region of PA are critical in mediating the PB2 E627K acquisition. Notably, due to the identity of viral PA protein, the polymerase activity and growth of H7N9 AIV are highly sensitive to changes in expression levels of human ANP32A protein. Furthermore, the impaired viral polymerase activity of H7N9 AIV caused by the depletion of ANP32A led to reduced virus replication in <i>Anp32a<sup>-/-</sup></i> mice, abolishing the acquisition of the PB2 E627K mutation and instead driving the virus to acquire the alternative PB2 D701N mutation. Taken together, our findings show that the emergence of the PB2 E627K mutation of H7N9 AIV is driven by the intrinsic low polymerase activity conferred by the viral PA protein, which also involves the engagement of mammalian ANP32A.<b>IMPORTANCE</b> The emergence of the PB2 E627K substitution is critical in the mammalian adaptation and pathogenesis of AIV. H7N9 AIVs that emerged in 2013 possess a prominent ability in gaining the PB2 E627K mutation in humans. Here, we demonstrate that the acquisition of the H7N9 PB2 E627K mutation is driven by the low polymerase activity conferred by the viral PA protein in human cells, and four PA residues are collectively involved in this process. Notably, the H7N9 PA protein leads to significant dependence of viral polymerase function on human ANP32A protein, and <i>Anp32a</i> knockout abolishes PB2 E627K acquisition in mice. These findings reveal that viral PA and host ANP32A are crucial for the emergence of PB2 E627K during adaptation of H7N9 AIVs to humans.
Abstract 19102: Cell Injection Site Influences the Human Mesenchymal Stem Cell Therapy Effectiveness for Left Ventricular Dysfunction in Ischemic Cardiomyopathy (2016)

Introduction: Clinical trials have shown that trans-endocardial stem cell injection (TESI) of mesenchymal stem cells (MSC) both reduced myocardial infarct scars and normalizes cardiac sphericity, 2...
Out-of-equilibrium lattice response to photo-induced charge-transfer in a MnFe Prussian blue analogue (2021)

Photo-induced charge-transfer in the RbMnFe Prussian blue analogue is coupled to a Jahn–Teller distortion, which results in an anisotropic crystalline lattice reorganization.
At-home sleep monitoring using generic ear-EEG (2023)

These results corroborate that generic ear-EEG is a promising alternative to the gold standard PSG for sleep stage monitoring. This will allow sleep stage monitoring to be performed in a less obtrusive way and over longer periods of time, thereby enabling diagnosis and treatment of diseases with associated sleep disorders.
A DSP-based implementation of a WCDMA reverse link design (2003)

This paper discusses a DSP (digital signal processor) implementation of a WCDMA (wideband code division multiple access) reverse link based on the TMS320C6201 fixed-point processor. The reverse link implementation does not include the analog channel modulation and demodulation blocks, but only the source encoding of the data and the spreading. The results of the real-time implementation are presented, along with the software optimization techniques employed.
Intelligent controlled three-phase squirrel-cage induction generator system using hybrid wavelet fuzzy neural network (2014)

An intelligent controlled three-phase squirrel-cage induction generator (SCIG) system for grid-connected wind power applications using hybrid wavelet fuzzy neural network (WFNN) is proposed in this study. First, the indirect field-oriented mechanism is implemented for the control of the SCIG system. Then, an AC/DC power converter and a DC/AC power inverter are developed to convert the electric power generated by a three-phase SCIG to power grid. Moreover, the dynamic model of the SCIG system and an ideal computed torque controller are developed for the control of the square of DC-link voltage. Furthermore, an intelligent hybrid WFNN controller and two WFNN controllers, which are computation intensive approaches, are proposed for the AC/DC power converter and the DC/AC power inverter respectively to improve the transient and steady-state responses of the SCIG system at different operating conditions. In the intelligent hybrid WFNN controller, to relax the requirement of the lumped uncertainty in the design of the ideal computed torque controller, a WFNN is designed as an uncertainty observer to adapt the lumped uncertainty online. Finally, the feasibility and effectiveness of the SCIG system for grid-connected wind power applications is verified with experimental results.
The preventive effect of verapamil on ethanol-induced cardiac depression: phosphorus-31 nuclear magnetic resonance and high-pressure liquid chromatographic studies of hamsters. (1987)

Alcoholic depression of left ventricular function was produced in normal hamsters by the administration of increasing concentrations of alcohol in drinking water (up to 50%) for 6 months. The result was assessed by phosphorus-31 nuclear magnetic resonance of isolated perfused hearts and high-pressure liquid chromatography of freeze-clamped tissues. Hemodynamic data and myocardial oxygen consumption were also monitored. Alcoholic hamsters had significantly higher inorganic phosphate and lower ATP levels, while maintaining normal intracellular pH, phosphocreatine, and creatine. Although coronary flow and oxygen consumption were maintained at normal levels, hamsters ingesting 50% ethanol had significantly lower left ventricular developed pressure and dP/dt. Treatment with verapamil during long-term ethanol consumption prevented the development of these metabolic and functional abnormalities. It is hypothesized that alcohol produces membrane abnormalities leading to adverse ion flux, and that these are largely prevented by concurrent administration of verapamil.
Thermal Needs and Challenges for the Solid State Lighting Devices: Materials to Packages (2005)

Light emitting diodes historically have been used for indicators and produced low amounts of heat. The introduction of high brightness LEDs with white light and monochromatic colors have led to a movement towards specialty and general illumination applications. The increased electrical currents used to drive the LEDs have focused more attention on the thermal paths in the LED packages and developments in LED power packaging. The luminous efficiency of LEDs is soon expected to reach over 80 Lumens/Watt that is approximately 6 times more than a conventional tungsten bulb. The thermal challenges include but not limited to chip architecture, packaging, phosphors for light conversion, encapsulants and fillers for optical transparency, interconnects for both electrical and thermal reasons. A typical LED power-package has a 1mm2 surface area with a total heat generation of 1 W. This corresponds to a heat flux of 100 W/cm2, which is much higher than heat fluxes at the current electronics packaging. In this paper, effect of the thermal management on packaging architectures, as well as phosphor and encapsulants are discussed. Discussions on the microscopic defects due to packaging problems as well as chip active layer defects are presented through experimental findings.
A highly reliable, high performance open avionics architecture for real time Nap-of-the-Earth operations (1995)

An Army Fault Tolerant Architecture (AFTA) has been developed to meet real-time fault tolerant processing requirements of future Army applications. AFTA is the enabling technology that will allow the Army to configure existing processors and other hardware to provide high throughput and ultrahigh reliability necessary for TF/TA/NOE flight control and other advanced Army applications. A comprehensive conceptual study of AFTA has been completed that addresses a wide range of issues including requirements, architecture, hardware, software, testability, producibility, analytical models, validation and verification, common mode faults, VHDL, and a fault tolerant data bus. A Brassboard AFTA for demonstration and validation has been fabricated, and two operating systems and a flight-critical Army application have been ported to it. Detailed performance measurements have been made of fault tolerance and operating system overheads while AFTA was executing the flight application in the presence of faults.
Endoscopic duodenal mucosal resurfacing improves glycaemic and hepatic indices in type 2 diabetes: 6-month multicentre results (2019)

Hydrothermal duodenal mucosal resurfacing (DMR) is an endoscopic technique designed to treat metabolic disease through ablation of the duodenal mucosa. DMR is a safe procedure which improves glycaemia and hepatic indices in patients with type 2 diabetes mellitus. DMR is an insulin-sensitizing intervention which can be complementary to lifestyle intervention approaches and pharmacological treatments aimed at preserving the pancreas and liver from failure. DMR is a potential therapeutic solution for patients with type 2 diabetes and fatty liver disease.