gebhart/patrepeval huggingface dataset:
Measurement of the azimuthal anisotropy of charged-particle production in Xe+Xe collisions at sNN=5.44 TeV with the ATLAS detector (2020)

This paper describes the measurements of flow harmonics v 2 -v 6 in 3 b -1 of Xe + Xe collisions at s NN = 5.44 TeV performed using the ATLAS detector at the Large Hadron Collider (LHC). Measurements of the centrality, multiplicity, and p T dependence of the v n obtained using two-particle correlations and the scalar product technique are presented. The measurements are also performed using a template-fit procedure, which was developed to remove nonflow correlations in small collision systems. This nonflow removal is shown to have a significant influence on the measured v n at high p T , especially in peripheral events. Comparisons of the measured v n with measurements in Pb + Pb collisions and p + Pb collisions at s NN = 5.02 TeV are also presented. The v n values in Xe + Xe collisions are observed to be larger than those in Pb + Pb collisions for n = 2, 3, and 4 in the most central events. However, with decreasing centrality or increasing harmonic order n, the v n values in Xe + Xe collisions become smaller than those in Pb + Pb collisions. The v n in Xe + Xe and Pb + Pb collisions are also compared as a function of the mean number of participating nucleons, N part , and the measured charged-particle multiplicity in the detector. The v 3 values in Xe + Xe and Pb + Pb collisions are observed to be similar at the same N part or multiplicity, but the other harmonics are significantly different. The ratios of the measured v n in Xe + Xe and Pb + Pb collisions, as a function of centrality, are also compared to theoretical calculations.
Essential Role for IKKβ in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells (2012)

Plasmacytoid dendritic cells (pDCs) are characterized by their ability to produce high levels of type 1 interferons in response to ligands that activate TLR7 and TLR9, but the signaling pathways required for IFN production are incompletely understood. Here we exploit the human pDC cell line Gen2.2 and improved pharmacological inhibitors of protein kinases to address this issue. We demonstrate that ligands that activate TLR7 and TLR9 require the TAK1-IKKβ signaling pathway to induce the production of IFNβ via a pathway that is independent of the degradation of IκBα. We also show that IKKβ activity, as well as the subsequent IFNβ-stimulated activation of the JAK-STAT1/2 signaling pathway, are essential for the production of IFNα by TLR9 ligands. We further show that TLR7 ligands CL097 and R848 fail to produce significant amounts of IFNα because the activation of IKKβ is not sustained for a sufficient length of time. The TLR7/9-stimulated production of type 1 IFNs is inhibited by much lower concentrations of IKKβ inhibitors than those needed to suppress the production of NFκB-dependent proinflammatory cytokines, such as IL-6, suggesting that drugs that inhibit IKKβ may have a potential for the treatment of forms of lupus that are driven by self-RNA and self-DNA-induced activation of TLR7 and TLR9, respectively.
A New Floating-Liner Test Rig Design to Investigate Factors Influencing Piston-Liner Friction (2012)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The largest contribution to engine rubbing friction is made by the piston and piston rings running in the cylinder liner. The magnitude and characteristics of the friction behaviour and the influence on these of factors such as surface roughness, piston design and lubricant properties are of keen interest. Investigating presents experimental challenges, including potential problems of uncontrolled build-to-build variability when component changes are made. These are addressed in the design of a new motored piston and floating liner rig. The design constrains transverse movement of a single liner using cantilevered mounts at the top and bottom. The mounts and two high stiffness strain gauged load cells constrain vertical movement. The outputs of the load cells are processed to extract the force contribution associated with friction. The liner, piston and crankshaft parts were taken from a EuroV-compliant, HPCR diesel engine with a swept capacity of 550cc per cylinder. Cooling, lubrication and an air injection system for cylinder pressure regulation are described. Example results are presented.&lt;/div&gt;&lt;/div&gt;
Abstract C112: Cabozantinib eradicates advanced murine prostate cancer by activating anti-tumor innate immunity (2015)

Abstract Several kinase inhibitors targeting aberrant signaling pathways in tumor cells have been deployed in cancer therapy. However, their impact on the tumor immune microenvironment remains poorly understood. The tyrosine kinase inhibitor cabozantinib showed striking responses in early phase clinical trials, particularly in cancer patients with bone metastases. Here we show that cabozantinib rapidly eradicates invasive, poorly-differentiated PTEN/p53 deficient murine prostate cancer. This was associated with increased neutrophil chemotactic factor expression, including CXCL12 and HMGB1 production by tumor cells, and robust infiltration of neutrophils into the tumor. Critically, cabozantinib-induced tumor clearance in mice was abolished by antibody-mediated granulocyte depletion or HMGB1 neutralization or blockade of neutrophil chemotaxis with the CXCR4 inhibitor, plerixafor. Collectively, these results demonstrate that cabozantinib triggers neutrophil-mediated anti-tumor innate immune response that results in tumor clearance. (Manuscript submitted to Science) Citation Format: Akash Patnaik, Kenneth Swanson, Sabina Signoretti, Huihui Ye, Eva Csizmadia, Jesse Novak, Marina Gehring, Katja Helenius, Athalia Pyzer, Laleh Montaser, Lily Wang, Olivier Elemento, Elena Levantini, John Clohessy, John Asara, Kathleen Kelly, Pier Paolo Pandolfi, Jacalyn Rosenblatt, David Avigan, Steven Balk, Lewis Cantley. Cabozantinib eradicates advanced murine prostate cancer by activating anti-tumor innate immunity. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr C112.
Autonomous Wireless Technology Detection in Seamless IoT Applications (2022)

The ever-increasing use of Internet of Things (IoT) devices results in the implementation of multiple wireless technologies that would not only cater their data rate requirements but also support various applications. To optimize the energy efficiency and security of the wireless transmission, it is imperative to identify the wireless technologies in various IoT implementations. Many of the existing approaches are based on measuring only the receiving signal strength indicator (RSSI). However, such approaches may not work well because of transmit power control and complex channel variations among different wireless technologies. In this article, we propose an autonomous wireless detection scheme that considers multiple distinguishable physical (PHY)-layer settings for real-time identification of wireless technologies for real-time applications. Specifically, the proposed scheme relies on the PHY-layer measurements of the targeted spectrum. Transmission settings, such as bandwidth, carrier frequency, and RSSI are estimated from the raw in-phase and quadrature-phase (I/Q) measurements. In addition, a symbol-level extraction scheme is implemented to extract unique features of modulation settings. These aforementioned features are applied to a machine learning process to identify the received wireless technologies. Compared with raw I/Q measurements, the extracted features are much simplified and, thus, the machine learning classifier can be designed with a simple structure for fast processing on IoT nodes. The proposed schemes are primarily evaluated theoretically, followed by implementing them on a USRP software-defined radio (SDR)-based hardware testbed. The evaluation results demonstrate high accuracy in the real-time detection of different wireless technologies for seamless IoT applications.
TPAMI CVPR Special Section (2013)

The articles in this special issue include papers from the CVPR'11 conference which was held in Colorado Spring, CO, June 2011.
Micropropulsion Research at AFRL (Postprint) (2000)

Abstract : There is an increased requirement for microsatellites to support such future missions as formation-flying space-based surveillance, space control, and on-orbit satellite servicing. Devices that can provide precise impulse bits in the 10-micro-Newton range may be enabling for a new fleet of 25-kg class spacecraft supporting these missions. In response to this need, the Air Force Research Laboratory is developing a miniaturized propulsion unit: the Micro-Pulsed Plasma Thruster (Micro-PPT). Like a standard PPT, the Micro-PPT uses a surface discharge across the face of a solid Teflon(trademark) propellant to create and accelerate a combination of plasma and neutral vapor. The Micro-PPT substantially differs from the standard design by using a self-igniting discharge, eliminating the separate igniter circuit from the thruster. This simplification enables order-of-magnitude reductions in the thruster size and operational power level. A technique for accurately measuring the performance of microthrusters has also been developed. Proof-of-concept performance measurements have been performed that indicate a non-optimized Micro-PPT has a thrust-to-power ratio that is approximately half that of LES-8/9 with a 60X reduction in mass.
MAV visual SLAM with plane constraint (2011)

Bundle adjustment (BA) which produces highly accurate results for visual Simultaneous Localization and Mapping (SLAM) could not be used for Micro-Aerial Vehicles (MAVs) with limited processing power because of its O(N <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) complexity. We observed that a consistent ground plane often exists for MAVs flying in both the indoor and outdoor urban environments. Therefore, in this paper, we propose a visual SLAM algorithm that make use of the plane constraint to reduce the complexity of BA. The reduction of complexity is achieved by refining only the current camera pose and most recent map points with BA that minimizes the reprojection errors and perpendicular distances between the most recent map points and the best fit plane with all the pre-existing map points. As a result, our algorithm is approximately constant time since the number of current camera pose and most recent map points remain approximately constant. In addition, the minimization of the perpendicular distances between the plane and map points would enforce consistency between the reconstructed map points and the actual ground plane.
UCO.MIPSIM: Pipelined computer simulator for teaching purposes (1970)

Since pipelining is a very important implementation technique for processors, students in Computer Science need to achieve a good understanding of it. UCO.MIPSIM simulator has been developed to support teaching such concepts. This paper introduces the bas
Engineering Foreign Exchange Processes via Commitment Protocols (2007)

Foreign exchange (FX) markets see a transaction volume of over $2 trillion per day. A number of standard ways of conducting business have been developed in the FX industry. However, current FX specifications are informal and their business semantics unclear. The resulting implementations tend to be complex and compliance with the standards unverifiable. This results in potential loss of value due to incompatible business processes and possible trades not consummated. This paper validates a formal, protocol-based approach by specifying foreign exchange processes as standardized by the TWIST consortium. The proposed approach formalizes a small, core set of foreign exchange interaction protocols on which the desired processes can be based. The core protocols can be composed to yield a large variety of possible processes. Each protocol is rigorously defined in terms of the commitments undertaken and manipulated by the parties involved. By contrast, traditional approaches as used in the current TWIST specification lead to redundancy in specification and difficulty in understanding the import of the interactions involved. In addition, our approach discovered interesting business scenarios that traditional approaches would have missed.
Treadmill exercise reduces spinal cord injury-induced apoptosis by activating the PI3K/Akt pathway in rats (2013)

Apoptosis occurring secondary to spinal cord injury (SCI) causes further neural damage and functional loss. In this study, a rat model was used to investigate the effect of treadmill exercise on SCI-induced apoptosis and expression of neurotrophic factors. To produce SCI, a contusion injury (10 g × 25 mm) was applied subsequent to laminectomy at the T9-T10 level. Following SCI, treadmill exercise was performed for six weeks. Hindlimb motor function was evaluated with a grid-walking test. The expression of neurotrophic factors and the level of apoptosis at the site of SCI were determined by western blotting. SCI reduced hindlimb motor function and suppressed expression of neurotrophin (NT)-3 and insulin-like growth factor (IGF)-1. Expression of phosphatidylinositol 3-kinase (PI3K), the ratio of phosphorylated Akt to Akt (pAkt/Akt) and the ratio of B-cell lymphoma 2 (Bcl-2) to Bax (Bcl-2/Bax) were decreased, and cleaved caspase-3 expression was increased by SCI. Treadmill exercise enhanced hindlimb motor function and increased expression of nerve growth factor (NGF), NT-3 and IGF-1 in the SCI rats. Treadmill exercise increased PI3K expression, the pAkt/Akt and the Bcl-2/Bax ratios, and suppressed cleaved caspase-3 expression in the injured spinal cord. This study demonstrated that treadmill exercise promotes the recovery of motor function by suppressing apoptosis in the injured spinal cord. The beneficial effect of exercise may be attributed to the increase in expression of neurotrophic factors via activation of the PI3K/Akt pathway.
Does Iron Deficiency Raise the Seizure Threshold? (1995)

To determine the effect of iron status on the seizure threshold, measures of iron sufficiency were prospectively evaluated in 51 children presenting to a pediatric emergency department with a febrile illness with (26) or without (25) an associated febrile seizure. A higher proportion of children from the febrile seizure group had a family history of mental retardation (5/26 versus 0/25, P = .02) or of previous febrile seizures (10/26 versus 2/23, P = .01). The two groups were otherwise comparable for age, sex, race, family history of afebrile seizures, temperature at presentation, white blood cell count, differential, and vitamin and antibiotic use. Patients with febrile seizures were less frequently iron deficient as defined by a free erythrocyte protoporphyrin level above 0.80 ng/L (2/23 versus 10/25, P < .01), hemoglobin concentration less than 110 g/L (1/26 versus 6/25, P < .03), hematocrit less than 0.30 L/L (0/22 versus 4/25, P < .02), mean corpuscular hemoglobin less than 20 pg (0/25 versus 3/24, P < .04), mean corpuscular volume less than 65 fL (0/26 versus 4/24, P < .02), and platelet count higher than 550 x 10(9)/L (0/26 versus 3/25, P < .04). This association was even stronger when adjusted for differences in family history. None of the patients in the febrile seizure group was being treated for iron deficiency at presentation, whereas three of 25 controls used an iron supplement (P < .04). Iron deficiency may protect against the development of febrile seizures.
Micellar proportion: A parameter to compare the hydrophobicity of the pseudostationary phases or that of the analytes in micellar electrokinetic chromatography (2005)

Micellar proportion, t(prop,mic) = t(mic)/t(m), a quantity expressing how much time is spent by the analyte in the micellar phase related to its whole migration time (t(m)) has been introduced by utilizing the micellar phase residence time (t(mic)). The t(prop,mic) values have been determined for analytes of different chemical structures (alkyl benzene and alkyl phenone homologous series, alcohols, strongly hydrophobic peptides) studied by micellar elektrokinetic chromatography (MEKC) using various cationic and anionic pseudostationary phases. A good linear correlation was obtained between t(prop,mic) and the calculated hydrophobicity (CLOGP) of the analytes for all pseudostationary phases (CLOGP = A.logt(prop,mic) + B). Considering a given pseudostationary phase, t(prop,mic) as a relative quantity is a suitable parameter to characterize and compare experimentally the behavior of the various analytes in MEKC. Applying a set of probe molecules with known hydrophobicity, the CLOGP(50) value (showing the value of hydrophobicity of a virtual molecule spending exactly 50% of its migration time in the pseudostationary phase) has been calculated for each pseudostationary phase applied here. This experimentally determinable numerical value (characterizing the pseudostationary phase) can be utilized to compare the hydrophobicity and hence retention ability of the pseudostationary phases. The t(prop,mic) value was found to be applicable to compare the methylene selectivity of the different pseudostationary phases as well: logt(prop,mic) = A.Z + B, where Z is the number of carbon atoms of the alkyl chain in the alkyl benzene homologous series.
Insight into the electrochemical activation of carbon-based cathodes for hydrogen evolution reaction (2015)

The anodic Pt dissolution, although widely ignored, should be taken into consideration during electrochemical tests when Pt metal is utilized as the counter electrode.
Multipath mitigation performance of multi-correlator based code tracking algorithms in closed and open loop model (2009)

Multipath is one of the dominant error sources in satellite-based positioning. It is a well known fact that the conventional code tracking loop suffers from performance degradation due to the presence of multipath. In past years, several advanced signal processing techniques have been devised to mitigate the multipath induced errors. One particular class of these signal processing techniques is the multi-correlator based feed-forward approach. The multipath performance of these feed-forward techniques has been extensively studied in open loop configuration by the authors in. The goal of this paper is to analyze the performance of these multi-correlator based feed-forward techniques in closed loop configuration, i.e., in the presence of an NCO and a loop filter, in multipath channels. Additionally, the delay tracking methods previously studied for BPSK and sine BOC signals are also studied here with the newly proposed multiplexed BOC modulation.
Essential Roles of Natural Products and Gaseous Mediators on Neuronal Cell Death or Survival (2016)

Although precise cellular and molecular mechanisms underlying neurodegeneration still remain enigmatic, key factors associated with degenerative disorders, such as glutamate toxicity and oxidative stress, have been recently identified. Accordingly, there has been growing interest in examining the effects of exogenous and endogenous molecules on neuroprotection and neurodegeneration. In this paper, we review recent studies on neuroprotective and/or neurodegenerative effects of natural products, such as caffeic acid and chlorogenic acid, and gaseous mediators, including hydrogen sulfide and nitric oxide. Furthermore, possible molecular mechanisms of these molecules in relation to glutamate signals are discussed. Insight into the pathophysiological role of these molecules will make progress in our understanding of molecular mechanisms underlying neurodegenerative diseases, and is expected to lead to potential therapeutic approaches.
Fast radiation mapping and multiple source localization using topographic contour map and incremental density estimation (2016)

Toward a global picture of the radiation exposure of an area, particularly for fast emergency response, a UAV based exploration method is proposed. Without a priori knowledge of the radiation field, it is difficult to select the region of interest (ROI) which includes all radiation sources. For the case of a single radiation source, a greedy algorithm may localize the source by finding the maximum radiation value. However, when multiple sources generate a hotspot in a cumulative manner, the hotspot position does not coincide with one of the source positions. Therefore, we propose an efficient exploration method to quickly localize the radiation sources using the following procedures: (1) ROI selection using topographic maps with specific radiation level selection methods and (2) source localization estimating the number of sources and their positions with incremental variational Bayes inference of Gaussian mixtures. Under three different conditions according to the number of sources and their positions, we have shown that the proposed model can reduce the ROI and significantly improve the estimation accuracy than existing methods.
Antigenicity and Immunogenicity of HIV-1 Envelope Trimers Complexed to a Small-Molecule Viral Entry Inhibitor (2020)

Small-molecule viral entry inhibitors, such as BMS-626529 (BMS-529), allosterically block CD4 binding to HIV-1 envelope (Env) and inhibit CD4-induced structural changes in Env trimers. Here, we show that the binding of BMS-529 to clade C soluble chimeric gp140 SOSIP (ch.SOSIP) and membrane-bound trimers with intact transmembrane domain (gp150) prevented trimer conformational transitions and enhanced their immunogenicity. When complexed to BMS-529, ch.SOSIP trimers retained their binding to broadly neutralizing antibodies (bNAbs) and to their unmutated common ancestor (UCA) antibodies, while exposure of CD4-induced (CD4i) non-bNAb epitopes was inhibited. BMS-529-complexed gp150 trimers in detergent micelles, which were isolated from CHO cells, bound to bNAbs, including UCA and intermediates of the CD4 binding site (bs) CH103 bNAb lineage, and showed limited exposure of CD4i epitopes and a glycosylation pattern with a preponderance of high-mannose glycans. In rabbits, BMS-529-complexed V3 glycan-targeting ch.SOSIP immunogen induced in the majority of immunized animals higher neutralization titers against both autologous and select high mannose-bearing heterologous tier 2 pseudoviruses than those immunized with the noncomplexed ch.SOSIP. In rhesus macaques, BMS-529 complexed to CD4 bs-targeting ch.SOSIP immunogen induced stronger neutralization against tier 2 pseudoviruses bearing high-mannose glycans than noncomplexed ch.SOSIP trimer immunogen. When immunized with gp150 complexed to BMS-529, rhesus macaques showed neutralization against tier 2 pseudoviruses with targeted glycan deletion and high-mannose glycan enrichment. These results demonstrated that stabilization of Env trimer conformation with BMS-529 improved the immunogenicity of select chimeric SOSIP trimers and elicited tier 2 neutralizing antibodies of higher potency than noncomplexed trimers.<b>IMPORTANCE</b> Soluble forms of HIV-1 envelope trimers exhibit conformational heterogeneity and undergo CD4-induced (CD4i) exposure of epitopes of non-neutralizing antibodies that can potentially hinder induction of broad neutralizing antibody responses. These limitations have been mitigated through recent structure-guided approaches and include trimer-stabilizing mutations that resist trimer conformational transition and exposure of CD4i epitopes. The use of small-molecule viral inhibitors that allosterically block CD4 binding represents an alternative strategy for stabilizing Env trimer in the pre-CD4-triggered state of both soluble and membrane-bound trimers. In this study, we report that the viral entry inhibitor BMS-626529 restricts trimer conformational transition and improves the immunogenicity of select Env trimer immunogens.