gebhart/patrepeval huggingface dataset:
L2TPv3 Extended Circuit Status Values (2009)

This document defines additional Layer 2 Tunneling Protocol Version 3
(L2TPv3) bit values to be used within the Circuit Status Attribute
Value Pair (AVP) to communicate more granular error states for
Attachment Circuits (ACs) and Pseudowires (PWs). It also generalizes
the Active bit and deprecates the use of the New bit in the Circuit
Status AVP, updating RFC3931, RFC4349, RFC4454, RFC4591, and RFC4719.
ChemInform Abstract: Transition Metal Catalyzed Cross Coupling Reactions (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Experimental demonstration of a multi-channel micro-optical bridge for multi-Gb/s, free-space intra-MCM interconnects (1998)

We demonstrate a 2.5Gb/s optical intra-MCM data link with a four-channel micro-optical bridge. This bridge was fabricated by deep proton lithography and monolithically integrates cylindrical lenses and micromirrors. 1.
Halogen bonding in hypervalent iodine and bromine derivatives: halonium salts (2017)

Halogen bonds have been identified in a series of ionic compounds involving bromonium and iodonium cations and several different anions, some also containing hypervalent atoms. The hypervalent bromine and iodine atoms in the examined compounds are found to have positive σ-holes on the extensions of their covalent bonds, while the hypervalent atoms in the anions have negative σ-holes. The positive σ-holes on the halogens of the studied halonium salts determine the linearity of the short contacts between the halogen and neutral or anionic electron donors, as usual in halogen bonds.
Purification of L-Type Pyruvate Kinase fromHuman Liver by Affinity Chromatography onBlue-Dextran-Sepharose Column (1977)

L-type pyruvate kinase (ATP: pyruvate 2-O-phosphotransferase; EC 2.7.1.40) was purified from human liver by an original method. This purification included toluene extraction, ammonium sulphate fractionation, DEAE-Sephadex batchwise, CM-Sephadex batchwise with elective elution by ATP and affinity chromatography on a Blue Dextran-Sepharose column with specific elution by fructose 1,6-diphosphate. This purification procedure allowed us to obtain 6 mg protein with a specific activity of 420 IU/mg protein, i.e. a 2,690-fold purification with an overall yield of 34%. This preparation was homogeneous as judged by immuno-diffusion, acrylamide and sodium dodecyl sulphate acrylamide-gel electrophoresis.
Correction to Structural Mass Spectrometry of the αβ-Tubulin Dimer Supports a Revised Model of Microtubule Assembly (2009)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Structural Mass Spectrometry of the αβ-Tubulin Dimer Supports a Revised Model of Microtubule AssemblyMelissa Bennett, John K. Chik, Gordon W. Slysz, Tyler Luchko, Jack Tuszynski, Dan L. Sackett, and David C. Schriemer*Cite this: Biochemistry 2009, 48, 40, 9704Publication Date (Web):September 16, 2009Publication History Received3 September 2009Published online16 September 2009Published inissue 13 October 2009https://pubs.acs.org/doi/10.1021/bi901540rhttps://doi.org/10.1021/bi901540rcorrectionACS PublicationsCopyright © 2009 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views478Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (567 KB) Get e-AlertscloseSUBJECTS:Mass spectrometry,Oligomers Get e-Alerts
Autoinhibited proteins as promising drug targets (2004)

Current drug discovery efforts generally focus on a limited number of protein classes, typically including proteins with well-defined catalytic active sites (e.g., kinases) or ligand binding sites (e.g., G protein-coupled receptors). Nevertheless, many clinically important pathways are mediated by proteins with no such obvious targets for small molecule inhibitors. Allosteric inhibitors offer an alternative approach to inhibition of protein activities, particularly for proteins that undergo conformational changes as part of their activity cycle. Proteins regulated by autoinhibitory domains represent one broad class of proteins that meets this criterion. In this article, we discuss the potential of autoinhibited proteins as targets for allosteric inhibitors and describe two examples of small molecules that act by stabilizing native autoinhibited conformations of their targets. We propose that proteins regulated by autoinhibition may be generally amenable to allosteric inhibition by small molecules that stabilize the native, autoinhibited fold.
Appropriate Hydrogen-Incorporated Diamond-Like Carbon Film for Application to Liquid Crystal Display (2007)

As an alternative alignment layer of polyimide, many kinds of alignment layers have been studied. Diamond-like carbon (DLC) is one of the good candidates due to its capability of aligning a liquid crystal (LC) homogeneously when it is irradiated by an ion beam (IB). To apply a DLC film to a display panel, not only LC alignment but also other properties such as pretilt angle, transmittance, resistivity, voltage holding ratio (VHR), and residual DC voltage (RDC) are important. One of the factors that affect these properties is hydrogen concentration within the DLC films. However, there are few research studies that elucidate the effects of hydrogen concentration on LC alignment and other properties in an LC cell. In this study, we showed the effects of hydrogen in a DLC film on several properties.
Three-dimensional thermomechanical converting of CTMP substrates: effect of bio-based strengthening agents and new mineral filling concept (2021)

Abstract The effects of bio-based strengthening agents and mineral filling procedure on the 3D elongation of chemi-thermomechanical pulp (CTMP) handsheets with and without mineral (PCC) filling have been investigated. The 3D elongation was measured using a press-forming machine equipped with a special converting tool. The strength of the handsheets was altered using either cationic starch or microfibrillated cellulose. Precipitated calcium carbonate (PCC) was added to the furnish either as a slurry or by precipitation of nano-sized PCC onto and into the CTMP fibre. The 3D elongation of unfilled sheets was increased by the dry-strengthening agents, but no evidence on the theorised positive effect of mineral fill on 3D elongation was seen in either filling method. The performance of the strengthening agent depended on whether the PCC was as slurry or as a precipitated PCC-CTMP. The starch was more effective with PCC-CTMP than when the PCC was added directly as a slurry to the furnish, whereas the opposite was observed with microfibrillated cellulose. The 3D elongation correlated positively with the tensile strength, bursting strength, tensile stiffness, elastic modulus and bending stiffness, even when the sheet composition was varied, but neither the strengthening agent nor the method of PCC addition affected the 3D elongation beyond what was expectable based on the tensile strength of the sheets. Finally, mechanisms affecting the properties that correlated with the 3D elongation are discussed.
DEVELOPMENT OF CONTINUOUS SOLVENT EXTRACTION PROCESSES FOR COAL DERIVED CARBON PRODUCTS (2005)

The purpose of this DOE-funded effort is to develop continuous processes for solvent extraction of coal for the production of carbon products. These carbon products include materials used in metals smelting, especially in the aluminum and steel industries, as well as porous carbon structural material referred to as ''carbon foam'' and carbon fibers. During this reporting period, efforts have focused on the development of continuous processes for hydrogenation as well as continuous production of carbon foam and coke.
Benzotrithiophene‐Based Hole‐Transporting Materials for 18.2 % Perovskite Solar Cells (2016)

New star-shaped benzotrithiophene (BTT)-based hole-transporting materials (HTM) BTT-1, BTT-2 and BTT-3 have been obtained through a facile synthetic route by crosslinking triarylamine-based donor groups with a benzotrithiophene (BTT) core. The BTT HTMs were tested on solution-processed lead trihalide perovskite-based solar cells. Power conversion efficiencies in the range of 16 % to 18.2 % were achieved under AM 1.5 sun with the three derivatives. These values are comparable to those obtained with today's most commonly used HTM spiro-OMeTAD, which point them out as promising candidates to be used as readily available and cost-effective alternatives in perovskite solar cells (PSCs).
The Use of a Microcalorimeter for Analysis of Load‐Dependent Processes Occurring in a Primary Battery (1978)

Calorimetry has been proposed as a way of measuring self‐discharge rates, particularly in very long‐lived primary batteries. A simple model for interpreting calorimetric data from a discharging ideal battery system is developed in terms of the battery's load‐voltage curve and limiting thermodynamic quantities. This treatment is extended to include real battery systems where self‐discharge and other types of parasitic processes occur. These complications are discussed and the model is applied to the and battery systems which are both important to the cardiac pacemaker industry. Anticipated and measured energy losses due to self‐discharge in these two systems appear to agree with the levels predicted via calorimetric data.
Photodynamic therapy using methylene blue in lung cancer animal models (2013)

Introduction: Photodynamic therapy (PDT) is used to treat early proximal bronchial cancer during a flexible bronchoscopy. The technique relies on the excitation of a photosensitizer by an appropriate wavelength, which is delivered into the bronchus in close contact with the tumor. Objective: To assess methylene blue (MB) as a PDT agent for the treatment of lung cancer in preclinical models. Methods: MB induced PDT was performed on cancerous lesions obtained both in the cheek pouch model, and on NCI-H460 tumoral xenografts in nude mice. Bilateral tumors were induced in each animal. PDT was carried out on right-sided tumors after intratumoral injection of methylene blue 1% (w/v) and illumination at 630 nm at 200 J/cm (Diomed PDT 630). The left tumor was used as control (illumination alone or methylene blue alone). The tumoral volume was assessed before and 15 days after PDT. Results: Nine carcinomas were treated in the cheek pouch model. MB-PDT produced a mean volume decrease of 85.8% (from 44.8% to 100%) (initial mean volume = 210 mm3 vs. final mean volume = 97 mm3). Histology analysis showed 4/9 complete responses. 14 xenografts were treated in mice, including 7 treated with MB-PDT, producing a 52% mean tumor volume regression (1568mm3 vs. 544mm3) compared to 7 controls in which tumor volume increased (p=0.007, Mann-Whitney test). Conclusion: Topical methylene blue appears unexpensive and efficient as PDT agent for lung cancer treatment. Further studies are needed to assess the safety and efficacy of MB-associated PDT for the treatment of cancerous bronchial lesions in humans. Financial support: French Ligue nationale against Cancer (Seine maritime and Eure Commitees) and ADIR, Rouen France.
ChemInform Abstract: BASED‐INDUCED REARRANGEMENTS OF α‐PHENYLSELENENYL KETONES (1982)

Abstract Aus den Phenylselenenyl‐ketonen (I) erhält man mit Lithiumdiisopropylamid die stereoisomeren Umlagerungsprodukte (II), die durch oxidative Eliminierung zu den Cycloalkenonen (III) führen.
BWR Steam Dryer Alternating Stress Assessment Procedures (2016)

This report presents an overview of Boiling Water Reactor (BWR) steam dryer design; the fatigue cracking failures that occurred at the Quad Cities (QC) plants and their root causes; a history of BWR Extended Power Uprates (EPUs) in the USA; and a discussion of steam dryer modifications/replacements, alternating stress mechanisms on steam dryers, and structural integrity evaluations (static and alternating stress).
100 kV g h o s t electron beam proximity correction on tungsten x-ray masks (1994)

100 kV electron beam exposures of tungsten x-ray masks have been made using ghost proximity correction. 0.15 μm lithography is possible on masks having a 0.3 μm thick tungsten absorber. 0.25 μm features are resolved on masks with a 0.6 μm tungsten film thickness. The linewidth control (±5%) and dose latitude (2.5 nm edge shift per 1% dose change) are as good or better than those obtained by dose modulation, and contrast is sufficiently high to permit dry etch pattern transfer into the tungsten absorber. The process latitude makes 100 kV ghost exposures suitable for patterning 1 Gbit dynamic random access memories on 1m x-ray masks.
Structural Characterization and in Vivo Evaluation of β-Hairpin Peptidomimetics as Specific CXCR4 Imaging Agents (2015)

The CXCR4 chemokine receptor is integral to several biological functions and plays a pivotal role in the pathophysiology of many diseases. As such, CXCR4 is an enticing target for the development of imaging and therapeutic agents. Here we report the evaluation of the POL3026 peptidomimetic template for the development of imaging agents that target CXCR4. Structural and conformational analyses of POL3026 and two of its conjugates, DOTA (POL-D) and PEG12-DOTA (POL-PD), by circular dichroism, two-dimensional NMR spectroscopy and molecular dynamics calculations are reported. In silico observations were experimentally verified with in vitro affinity assays and rationalized using crystal structure-based molecular modeling studies. [(111)In]-labeled DOTA conjugates were assessed in vivo for target specificity in CXCR4 expressing subcutaneous U87 tumors (U87-stb-CXCR4) through single photon emission computed tomography (SPECT/CT) imaging and biodistribution studies. In silico and in vitro studies show that POL3026 and its conjugates demonstrate similar interactions with different micelles that mimic cellular membrane and that the ε-NH2 of lysine(7) is critical to maintain high affinity to CXCR4. Modification of this group with DOTA or PEG12-DOTA led to the decrease of IC50 value from 0.087 nM for POL3026 to 0.47 nM and 1.42 nM for POL-D and POL-PD, respectively. In spite of the decreased affinity toward CXCR4, [(111)In]POL-D and [(111)In]POL-PD demonstrated high and significant uptake in U87-stb-CXCR4 tumors compared to the control U87 tumors at 90 min and 24 h post injection. Uptake in U87-stb-CXCR4 tumors could be blocked by unlabeled POL3026, indicating specificity of the agents in vivo. These results suggest POL3026 as a promising template to develop new imaging agents that target CXCR4.
ChemInform Abstract: Nakijiquinones G—I, New Sesquiterpenoid Quinones from Marine Sponge. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Stochastic Modeling of Lotus Notes with a Queueing Model. (2001)

With the increasing popularity and diversity of computer systems, quality of services for computer applications becomes more and more important. In order to facilitate the theoretical studies on the computer performance management problem, an effective simulation environment is desired. In this paper, we propose a methodology of extracting a queueing model from the measurements of computer systems. In particular, a queueing simulator in the form of a closed queueing network is constructed from Lotus Notes log files with demonstrated accuracy. 1
In-Situ Determination of Constituent Properties and Performance in an Oxide-Oxide CFCC (2008)

Oxide fibre-reinforced / oxide matrix CFCCs have the potential of resisting high-temperature degradation in the increasingly aggressive environments of the emerging applications of this still-evolving class of materials. However, a major design and processing limitation CFCCs is lack of information on the in-situ properties and performance of the composites constituents (i.e., fibres, interphase, matrix). Phenomenological and analytical evaluations of unload/reload tensile test results (i.e., hysteretic stress-strain response) were used to extract information on residual stress state, interfacial shear stress, and other constituent behaviour in an Al2O3 (Nextel™) fibre-reinforced / Al2O3 (DIMOX™) matrix composite with an oxidation-resistant BN/SiC interphase. Both monotonic and unload/reload tensile tests at room temperature were conducted on test specimens that had been exposed to 600, 800, 1000 and 1200°C temperatures in ambient air for 10 and 100 h. Other tests (e.g., impulse resonance; TGA/DTA; and fractography) substantiated micromechanics of the observed tensile behavior.
Subcellular Partitioning and Analysis of Gd3+-Loaded Ultrashort Single-Walled Carbon Nanotubes (2015)

Magnetic resonance imaging (MRI) is of vast clinical utility, with tens of millions of scans performed annually. Chemical contrast agents (CAs) can greatly enhance the diagnostic potential of MRI, and ∼50% of MRI scans use CAs. However, CAs have significant limitations such as low contrast enhancement, lack of specificity, and potential toxicity. Recently developed, Gd3+-loaded ultrashort single-walled carbon nanotubes, also referred to as gadonanotubes or GNTs, exhibit ∼40 times the relaxivities of clinical CAs, representing a potential major advance in clinically relevant MRI CA materials. Although initial cytotoxicity and MRI studies have suggested great promise for GNTs, relatively little is known regarding their subcellular interactions, which are crucial for further, safe development of GNTs as CAs. In this work, we administered GNTs to a well-established human cell line (HeLa) and to murine macrophage-like cells (J774A.1). GNTs were not acutely cytotoxic and did not reduce proliferation, except for the highest exposure concentration of 27 μg/mL for J774A.1 macrophages, yet bulk uptake of GNTs occurred in minutes at picogram quantities, or millions of GNTs per cell. J774A.1 macrophages internalized substantially more GNTs than HeLa cells in a dose-dependent manner, and Raman imaging of the subcellular distribution of GNTs revealed perinuclear localization. Fluorescence intensity and lifetime imaging demonstrated that GNTs did not grossly alter subcellular compartments, including filamentous-actin structures. Together, these results provide subcellular evidence necessary to establish GNTs as a new MRI CA material.
Breast cancer detection using Ktrans MRI imaging to guide near infrared spectroscopy tomography (2017)

The parametric image of Volume Transfer Coefficient (K<sub>trans</sub>) in MRI has been used to guide image reconstruction of Near-Infrared Spectral Tomography (NIRST). The image reconstruction used direct regularization, in which no segmentation has been involved. A total of 24 patients were involved in this study and the reconstructed results show that the tumor total hemoglobin (HbT) contrast could be used to differentiate the malignant from the benign cases (p-value= 0.018). The addition of the MRI information allows more accurate and definitive HbT values from the NIRST.
Structural characterization and fluxional behavior of cyclohexenylmanganese tricarbonyl. Intramolecular carbon-hydrogen bond activation via a 2-electron, 3-center manganese...hydrogen...carbon interaction (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural characterization and fluxional behavior of cyclohexenylmanganese tricarbonyl. Intramolecular carbon-hydrogen bond activation via a 2-electron, 3-center manganese...hydrogen...carbon interactionM. Brookhart, W. Lamanna, and M. Beth HumphreyCite this: J. Am. Chem. Soc. 1982, 104, 8, 2117–2126Publication Date (Print):April 1, 1982Publication History Published online1 May 2002Published inissue 1 April 1982https://pubs.acs.org/doi/10.1021/ja00372a006https://doi.org/10.1021/ja00372a006research-articleACS PublicationsRequest reuse permissionsArticle Views257Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Low central blood pressure and sympathetic activity predispose for the development of intradialytic hypotension (2021)

Intradialytic hypotension (IDH) may lead to a poor life quality and was associated with cardiovascular mortality in patients under hemodialysis. This study investigated the autonomic nerve and cardiovascular function in the IDH episodes.In this case-control study, 70 end stage renal disease patients (198 visits) were recruited. Pulse wave analysis and heart rate variability were evaluated before hemodialysis. Two definitions of IDH were confirmed by medical records. IDH-f indicated a drop of systolic blood pressure or mean arterial pressure, accompanied with symptoms; IDH-n indicated a low nadir systolic pressure during the hemodialysis. All parameters were evaluated for the possible predisposing factors under each definition.A total of 24 IDH-f and 37 IDH-n were noted in 177 visits. For both definitions, central pulse pressure seemed to be a consistent predisposing factor. Furthermore, lower sympathetic activity (odds ratio [OR] 0.55; 95% confidence interval [CI] 0.35-0.87), lower pulse pressure (OR 0.95; 95% CI 0.92-0.98), and higher augmentation index (OR 17.36; 95% CI 1.48-204.10) were the possible predisposing factors for IDH-f. On the contrary, lower mean arterial pressure (OR 0.87; 95% CI 0.78-0.98) was identified as the possible factor for IDH-n.It was suggested that the lower central pulse pressure and sympathetic activity might be involved in the development of IDH.