gebhart/patrepeval huggingface dataset:
High-Temperature Dielectrics in BNT-BT-Based Solid Solution (2016)

Bi<sub>0.5</sub>Na<sub>0.5</sub>TiO<sub>3</sub>-BaTiO<sub>3</sub> (BNT-BT)-based ternary solid solutions were investigated for high-temperature capacitor applications. Through a comprehensive investigation of the (1 - x )(0.92Bi<sub>0.5</sub>Na<sub>0.5</sub>TiO<sub>3</sub>-0.08BaTiO<sub>3</sub>)- x NaNbO<sub>3</sub> [(1 - x )(BNT-BT)- x NN, x = 0 -0.45] system, 0.85(BNT-BT)-0.15NN was selected as the parent matrix due to its relatively high permittivity (>1800) and favorable energy-storage density (0.56 J/cm<sup>3</sup> at 7 kV/mm). The effect of bismuth substitution on the dielectric properties of the matrix was further characterized. The introduction of bismuth greatly broadened the operational temperature range of 0.85(BNT-BT)-0.15Na<sub>1-3y</sub>Bi<sub>y</sub>NbO<sub>3</sub> ceramics to over 327 °C for a ±15% tolerance. The dc resistivities were of the order of 10<sup>8</sup> - [Formula: see text] magnitude from room temperature to 300 °C. An activation energy of 1.1-1.2 eV in 200-350 °C was obtained from dc resistivity data, suggesting that the conduction process in this temperature range may be associated with oxygen vacancy migration. Furthermore, the energy-storage properties were largely improved by the addition of bismuth. When the substitution of Bi over Na achieved was up to 7%, the energy-storage density and efficiency reached 0.62 J/cm<sup>3</sup> and 88% at 7 kV/mm, respectively. These results confirm that a BNT-BT-based solid solution is a promising candidate for lead-free high-temperature capacitor applications.
PCM-Graphite Latent Heat Storage Systems for Industrial Process Heat Recovery (2010)

Increasing energy prices and shortage of fossil fuels lead to a growing interest in alternative energy sources. In combination with energy storage systems the generation of solar process heat can be provided independent from the weather leading for example to a cost efficient stabilization of power output. For this application latent heat storage units with phase change materials (PCMs) can be designed to store solar process heat within a narrow temperature interval utilizing the high storage density of the different PCMs. This is achieved using the latent heat of melting in the melting / solidification process, or the latent heat of re-crystallization in a solid / solid phase transition. However, this advantage can only be used in technical applications if the heat transfer in the PCM is sufficiently high. As most pure PCMs exhibit a low thermal conductivity (about 1 W/(m•K) or less), methods to improve heat transfer in PCMs have been under investigation for decades. The heat transfer in a PCM can be increased by addition of highly thermal conductive materials. Due to its superior properties - high thermal conductivity, good processability, and chemical inertness - graphite has distinct advantages for this purpose. Depending on the requirements of the respective application, various routes to combine PCM and graphite are used. For example, besides the fabrication of PCM/graphite composite materials, the increase of heat exchanger surface by highly thermal conductive graphite plates is a favorable method for large scale applications, in particular. Effective thermal conductivities up to 30 W/(m•K) have been realized. This paper gives an overview of actual and potential applications of PCM/graphite heat storage systems focusing on storage of solar heat for high temperature applications such as process heat generation and solar thermal power plants.
Structural Waveguides for Aerodynamic Turbulent Drag Reduction (2007)

Abstract : The objective of this project was to provide a proof-of-concept that travelling wave disturbances on the surface of a vehicle can generate viscous drag reduction benefits. This would be accomplished by developing structural waveguides within a cylinder that under actuation impart a structural surface wave disturbance in the form of a travelling wave. During the nine month performance of the work presented herein we were successful indesigning and fabricating structural waveguides. Structural characterization of the prototype demonstrates that the performance met the design expectation. Subsequently, initial aerodynamic testing was performed in order to validate that the proposed concept can impart flow disturbances that reduce turbulent viscous drag. At the time of this report only quantitative flow visualization under quiescent flow conditions had been performed and preliminary analysis of the results is presented. The PIV results showed a three stage cycle occurring, which creates a motion that sweeps the flow very close to the wall in a clockwise direction. This movement of fluid might interrupt the near-wall turbulence production.
One Hundred Ninety-Five Cases of High-Voltage Electric Injury (2005)

High-voltage electric injury (HVEI) is associated with a high incidence of extremity compartment syndrome and of major amputation. The purpose of this study was to review our experience with HVEI and to attempt to develop predictors of the need for fasciotomy and amputation in patients with HVEI. The records of the 195 patients with HVEI who were admitted to a single burn center during a 19-year period were reviewed. Evidence for muscle necrosis, to include myoglobinuria and elevated creatine phosphokinase (CPK) levels, was noted. A total 187 patients (95.9%) survived to hospital discharge. A total of 56 underwent fasciotomy within 24 h of injury; 80 patients underwent an amputation during the hospitalization. Fasciotomy was predicted by presence of myoglobinuria with an overall accuracy of 72.8%. Amputation was predicted by a logistic model incorporating myoglobinuria, undergoing a previous fasciotomy, and age, with an overall accuracy of 73.3%. HVEI was associated with high amputation risk and a low rate of mortality in patients admitted to our burn center. Patients with gross myoglobinuria are at higher risk of requiring fasciotomy and/or amputation.
p53 and Cell Cycle Proteins Participate in Spinal Motor Neuron Cell Death in ALS~!2010-02-16~!2010-02-19~!2010-04-14~! (2010)

Apoptosis has been implicated in many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). We previously demonstrated a role for G1 to S phase cell cycle regulators in ALS with increased levels of hyperphosphorylated retinoblastoma (ppRb) and E2F-1 in ALS spinal cord motor neurons. In this study we examined the levels of the cell cycle checkpoint tumor suppressor protein p53 with concurrent changes in cell death markers during ALS. Expression and subcellular distribution of p53, retinoblastoma, Bax, Fas, and caspases were explored by immunoblot, immunohistochemistry and double-label confocal microscopy in the spinal cord and motor cortex of ALS and control subjects. We identified elevated levels of p53 in ALS spinal cord motor neurons but not neurons in the motor cortex. In addition, there was an increase in Bax, Fas, caspases-8 and -3 proteins in ALS spinal motor neurons. While caspase-3 and TUNEL labeled neurons were positive for ppRb, E2F-1 and p53 in spinal motor neurons, and Fas co-localized with caspase-8 in spinal motor neurons, we failed to observe these results in large neurons in the motor cortex of ALS subjects. We have linked p53 and activation of G1 to S phase cell cycle regulators to an apoptotic mode of cell death ALS spinal cord motor neurons.
Structure of an inducibly methylatable nucleotide sequence in 23S ribosomal ribonucleic acid from erythromycin-resistant Staphylococcus aureus (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of an inducibly methylatable nucleotide sequence in 23S ribosomal ribonucleic acid from erythromycin-resistant Staphylococcus aureusChing-Juh Lai, James E. Dahlberg, and Bernard WeisblumCite this: Biochemistry 1973, 12, 3, 457–460Publication Date (Print):January 1, 1973Publication History Published online1 May 2002Published inissue 1 January 1973https://pubs.acs.org/doi/10.1021/bi00727a015https://doi.org/10.1021/bi00727a015research-articleACS PublicationsRequest reuse permissionsArticle Views73Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Session Initiation Protocol (SIP) Event Package for Communication Diversion Information in support of the Communication Diversion (CDIV) Notification (CDIVN) CDIV service (2013)

3GPP and TISPAN are defining the protocol specification for the
Communication Diversion (CDIV) service using IP Multimedia (IM) Core
Network (CN) subsystem (IMS) supplementary service. As part of CDIV, a
SIP based event package is used for notifying users about diversions
(re-directions or forwarding) of requests for communication sessions
targetting the user. This document defines the SIP event package to
support subscription and notification of diversions. The proposed
event package is applicable to the CDIV supplementary service in IMS
and may not be applicable to the general internet.
Distortion Analysis and Equivalent Multiplicative and Additive Noise Model for High-Speed DAC and ADC (2023)

By analyzing the distortions of time-interleaving convertors, equivalent model with both multiplicative and additive noises is proposed and constructed by tone-based measurements. Experiments show that the proposed model estimates system performance with 0.2 dB accuracy.
Influenza D binding properties vary amongst the two major virus clades and wildlife species (2021)

The influenza D virus (IDV) uses a trimeric hemagglutinin-esterase fusion protein (HEF) for attachment to 9-O-acetylated sialic acid receptors on the cell surface of host species. So far research has revealed that farm animals such as cattle, domestic pigs, goats, sheep and horses contain the necessary receptors on the epithelial surface of the respiratory tract to accommodate binding of the IDV HEF protein of both worldwide clades D/Oklahoma (D/OK) and D/Oklahoma/660 (D/660). More recently, seroprevalence studies have identified IDV-seropositive wildlife such as wild boar, deer, dromedaries, and small ruminants. However, no research has thus far been conducted in wildlife to reveal the distribution of acetylated sialic acid receptors that accommodate binding of IDV. Using our previously developed tissue microarray (TMA) system, we developed TMAs containing respiratory tissues of various wild and domestic species including wild boar, deer, dromedary, springbok, water buffalo, tiger, hedgehog, and Asian elephant. Protein histochemical staining of these TMAs with HEF proteins showed no receptor binding for wild Suidae, Cervidae and tiger. However, receptors were present in dromedary, springbok, water buffalo, Asian elephant, and hedgehog. In contrast to previously tested farm animals, a difference in host tropism was observed between the D/OK and D/660 clade HEF proteins in Asian elephant, and water buffalo. These results show that IDV can attach to the respiratory tract of wildlife which might facilitate transmission of IDV between wildlife and domestic animals.
Alchimies futures : compte rendu de l'expérience ESYOP (2005)

« Quelle chimie organique demain ? » Cet article présente les conclusions de la première édition des entretiens de synthèse organique et de prospective (ESYOP), dont l'objectif était d'apporter une réponse collective à cette question fondamentale. Les défis mis en évidence par une trentaine de jeunes chercheurs francophones de la génération 30–39 ans peuvent se regrouper suivant trois thèmes interdépendants : la conquête du simple, la nature comme guide et la conception d'édifices moléculaires capables d'autonomie et d'adaptabilité. Le visage de la chimie organique de demain sera peut-être celui d'une science cherchant à construire avec une grande économie de moyens des systèmes moléculaires inspirés de la nature et dotés d'une forme d'intelligence. .
Data from Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion Variants (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt;&lt;i&gt;ALK&lt;/i&gt; rearrangement–positive lung cancers can be effectively treated with ALK inhibitors. However, the magnitude and duration of response is heterogeneous. In addition, acquired resistance limits the efficacy of ALK inhibitors, with most upfront resistance mechanisms being unknown.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; By making use of the Ba/F3 cell line model, we analyzed the cytotoxic efficacy of ALK kinase inhibitors as a function of different &lt;i&gt;EML4-ALK&lt;/i&gt; fusion variants &lt;i&gt;v1&lt;/i&gt;, &lt;i&gt;v2, v3a&lt;/i&gt;, and &lt;i&gt;v3b&lt;/i&gt; as well as of three artificially designed &lt;i&gt;EML4-ALK&lt;/i&gt; deletion constructs and the &lt;i&gt;ALK&lt;/i&gt; fusion genes &lt;i&gt;KIF5b-ALK&lt;/i&gt; and &lt;i&gt;NPM1-ALK&lt;/i&gt;. In addition, the intracellular localization, the sensitivity to HSP90 inhibition and the protein stability of &lt;i&gt;ALK&lt;/i&gt; fusion proteins were studied.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Different &lt;i&gt;ALK&lt;/i&gt; fusion genes and &lt;i&gt;EML4-ALK&lt;/i&gt; variants exhibited differential sensitivity to the structurally diverse ALK kinase inhibitors crizotinib and TAE684. In addition, differential sensitivity correlated with differences in protein stability in &lt;i&gt;EML4-ALK&lt;/i&gt;–expressing cells. Furthermore, the sensitivity to HSP90 inhibition also varied depending on the ALK fusion partner but differed from ALK inhibitor sensitivity patterns. Finally, combining inhibitors of ALK and HSP90 resulted in synergistic cytotoxicity.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our results might explain some of the heterogeneous responses of &lt;i&gt;ALK&lt;/i&gt;-positive tumors to ALK kinase inhibition observed in the clinic. Thus, targeted therapy of &lt;i&gt;ALK&lt;/i&gt;-positive lung cancer should take into account the precise &lt;i&gt;ALK&lt;/i&gt; genotype. Furthermore, combining ALK and HSP90 inhibitors might enhance tumor shrinkage in &lt;i&gt;EML4-ALK&lt;/i&gt;–driven tumors. &lt;i&gt;Clin Cancer Res; 18(17); 4682–90. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Bishomoaromatic stabilization of bicyclic anions (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBishomoaromatic stabilization of bicyclic anionsWilliam N. WashburnCite this: J. Org. Chem. 1983, 48, 23, 4287–4289Publication Date (Print):November 1, 1983Publication History Published online1 May 2002Published inissue 1 November 1983https://pubs.acs.org/doi/10.1021/jo00171a026https://doi.org/10.1021/jo00171a026research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Absolute Quantification of Histone PTM Marks by MRM-Based LC-MS/MS (2014)

The N-terminal tails of core histones harbor the sites of numerous post-translational modifications (PTMs) with important roles in the regulation of chromatin structure and function. Profiling histone PTM marks provides data that help understand the epigenetics events in cells and their connections with cancer and other diseases. Our previous study demonstrated that specific derivatization of histone peptides by NHS propionate significantly improved their chromatographic performance on reversed phase columns for LC/MS analysis. As a step forward, we recently developed a multiple reaction monitoring (MRM) based LC-MS/MS method to analyze 42 targeted histone peptides. By using stable isotopic labeled peptides as internal standards that are spiked into the reconstituted solutions, this method allows to measure absolute concentration of the tryptic peptides of H3 histone proteins extracted from cancer cell lines. The method was thoroughly validated for the accuracy and reproducibility through analyzing recombinant histone proteins and cellular samples. The linear dynamic range of the MRM assays was achieved in 3 orders of magnitude from 1 nM to 1 μM for all targeted peptides. Excellent intrabatch and interbatch reproducibility (<15% CV) was obtained. This method has been used to study translocated NSD2 (a histone lysine methyltransferase that catalyzes the histone lysine 36 methylation) function with its overexpression in KMS11 multiple myeloma cells. From the results we have successfully quantitated both individual and combinatorial histone marks in parental and NSD2 selective knockout KMS11 cells.
ChemInform Abstract: A Short Total Synthesis of Cerpegin (VI) by Intramolecular Hetero Diels—Alder Cycloaddition Reaction of an Acetylene‐Tethered Pyrimidine. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The risk of carcinoma in wire localization biopsies for mammographically detected clustered microcalcifications. (1991)

A total of 183 consecutive patients undergoing biopsies for unilateral microcalcifications concentrated in one or more segments of the breast in the absence of any palpable findings were analyzed to characterize their risk of cancer. Biopsy findings were benign in 86 patients (47%) and malignant in 97 (53%). Of the clinical and mammographic characteristics evaluated, an increasing number of linear microcalcifications, either without a dominant density (p = 0.014) or with a dominant density (p = 0.019) and the presence of heterogeneous microcalcifications (p = 0.055), were associated with a significantly increased risk of malignancy. Conversely a fibronodular parenchymal pattern (p = 0.008) was associated with a significantly decreased risk of malignancy. A high-risk group was identified, 95% (40/42) of whom had malignant biopsy findings, whose mammograms had more than 10 linear microcalcifications not associated with a dominant density (16/17) or at least one linear microcalcification associated with a dominant density (24/25). Conversely a low-risk group for cancer was identified, 88% (28/32) of whom had benign biopsy findings, whose mammograms had exclusively punctate microcalcifications within a fibronodular parenchymal milieu (26/30) or demonstrated some change in the configuration of the microcalcifications on the various mammographic views (10/10). For the remaining 109 patients there was an almost equal division between malignant and benign diagnoses (49% vs 51%).
How general is the nucleation–condensation mechanism? (2008)

We investigate the structures of the major folding transition states of nine proteins by correlation of published Phi-values with inter-residue contact maps. Combined with previous studies on six proteins, the analysis suggests that at least 10 of the 15 small globular proteins fold via a nucleation-condensation mechanism with a concurrent build-up of secondary and tertiary structure contacts, but a structural consolidation that is clearly nonuniformly distributed over the molecule and most intense in a single structural region suggesting the occurrence of a single folding nucleus. However, on average helix- and sheet-forming residues show somewhat larger Phi-values in the major transition state, suggesting that secondary structure formation is one important driving force in the nucleation-condensation in many proteins and that secondary-structure forming residues tend to be more prominent in folding nuclei. We synthesize the combined information on these 10 of 15 proteins into a unified nucleation-condensation mechanism which also accounts for effects described by the framework, hydrophobic collapse, zipper, and funnel models.
The secretome of honey bee-specific lactic acid bacteria inhibits Paenibacillus larvae growth (2019)

American Foulbrood (AFB) is a particularly pernicious bacterial disease of honey bees due to the extreme persistence of endospores of the causative agent Paenibacillus larvae. These spores are resistant to harsh environmental conditions, unaffected by antimicrobial agents and can remain viable for decades. The germination of the endospore in the larval midgut is the crucial first step leading to infection, followed by vegetative growth, tissue invasion and disease, culminating in spore formation when the host´s nutrients have been exhausted. Therefore, inhibiting spore germination or impeding early vegetative growth would be a highly effective strategy for limiting the impact of AFB. We previously showed that honey bee-specific lactic acid bacteria (hbs–LAB) had a major inhibitory effect on P. larvae both in culture and in larval bioassays. The present study documents the progress towards characterization of compounds, processes and interactions between P. larvae and the hbs–LAB responsible for this inhibitory effect. Firstly, we used an agar diffusion assay and larval infection bioassay to show that most, if not all, of the inhibitory effect was associated with the extracellular fraction (secretome). Secondly, we employed a turbidimetric growth assay to demonstrate that the hbs–LAB secretome strongly inhibited P. larvae vegetative growth, however, probably not by reducing spore germination. The inhibition was similarly effective against both major P. larvae genotypes (ERIC-I and II) in all experiments. The implications of our results for characterization of the secretome and for the management and treatment of AFB and P. larvae are further discussed.