gebhart/patrepeval huggingface dataset:
Characterization of a high-resolution breath acetone meter for ketosis monitoring (2020)

ABSTRACT Background The ketone bodies beta-hydroxybutyrate (BHB) and acetone are endogenous products of fatty acid metabolism. Although ketone levels can be monitored by measuring either blood BHB or breath acetone, determining the precise correlation between these two measurement methods has been challenging. The purpose of this study is to characterize the performance of a novel portable breath acetone meter (PBAM) developed by Readout, Inc., to compare single versus multiple daily ketone measurements, and to compare breath acetone (BrAce) and blood BHB measurements. Methods We conducted a 14-day prospective observational cohort study of 21 subjects attempting to follow either a low-carbohydrate/ketogenic or a standard diet. Subjects were asked to concurrently measure both blood BHB and BrAce five times per day and report the results using an online data entry system. We evaluated the utility of multiple daily measurements by calculating the coefficient of variation (CV) for each daily group of measurements. We calculated the correlation between coincident BrAce and blood BHB measurements using linear ordinary least squares regression analysis. We assessed the ability of the BrAce measurement to accurately predict blood BHB states using receiver operating characteristic (ROC) analysis. Finally, we calculated a daily ketone exposure (DKE) using the area under the curve (AUC) of a ketone concentration versus time graph and compared the DKE of BrAce and blood BHB using linear ordinary least squares regression. Results BrAce and blood BHB varied throughout the day by an average of 44% and 46%, respectively. The BrAce measurement accurately predicted whether blood BHB was greater than or less than the following thresholds: 0.3 mM (AUC = 0.898), 0.5 mM (AUC = 0.854), 1.0 mM (AUC = 0.887), and 1.5 mM (AUC = 0.935). Coincident BrAce and blood BHB measurements were moderately correlated with R 2 = 0.57 ( P &lt; 0.0001), similar to literature reported values. However, daily ketone exposures, or areas under the curve, for BrAce and blood BHB were highly correlated with R 2 = 0.83 ( P &lt; 0.0001). Conclusions The results validated the performance of the PBAM. The BrAce/BHB correlation was similar to literature values where BrAce was measured using highly accurate lab instruments. Additionally, BrAce measurements using the PBAM can be used to predict blood BHB states. The relatively high daily variability of ketone levels indicate that single blood or breath ketone measurements are often not sufficient to assess daily ketone exposure for most users. Finally, although single coincident blood and breath ketone measurements show only a moderate correlation, possibly due to the temporal lag between BrAce and blood BHB, daily ketone exposures for blood and breath are highly correlated.
Flow Cytometry in Transfusion Medicine: Development, Strategies and Applications (2004)

Nowadays, flow cytometry represents an essential tool for the daily work in laboratories for transfusion medicine. After cytophotometry of immobilized cells, flow cytometry was developed since the 1960s using moving fluorescence-stained cells. This technique enabled the determination of several thousand cells per second, e.g. from blood, bone marrow, or organ-associated cell suspensions. The introduction of monoclonal fluorescence-labeled antibodies in diagnostics has further accelerated the development of flow cytometry. In the meantime, numerous cellular and nuclear properties can simultaneously be measured on single cell level in automated devices at high speed and precision. Internal standards and quality control systems further increased the accuracy of flow cytometric analyses. Flow cytometry is therefore likewise suitable for routine diagnostics in patients, quality control of blood components and scientific purposes in transfusion medicine. Nevertheless, many flow cytometric applications are related to counting of rare events or detection of cells with low antigen expression. Therefore, several pre-analytic and analytic factors (e.g. erythrocyte lysing procedures, cell gating strategies, etc.) may essentially affect the accurate determination of cell numbers and functions. In this issue, TRANSFUSION MEDICINE AND HEMOTHERAPY starts a recurrent sequence of reviews focused on ‘Flow Cytometry in Transfusion Medicine’. In order to introduce the flow cytometry series, this review summarizes the development, principles, and strategies of flow cytometry as an increasing diagnostic tool in medical laboratories. Also, current and possibly future flow cytometric applications in transfusion medicine are epitomized, e.g. quality control of blood products, immunohematologic diagnostics, hematopoietic progenitor cell transplantation, adoptive immunotherapy, and further therapeutic applications. In following issues of this journal, reviews of notable authors will then focus on special applications and give more detailed insights into single diagnostic fields.
A Simple and Efficient Method to Handle Sparse Preference Data Using Domination Graphs: An Application to YouTube (2016)

The phenomenal growth of the number of videos on YouTube provides enormous potential for users to find content of interest to them. Unfortunately, as the size of the repository grows, the task of discovering high-quality content becomes more daunting. To address this, YouTube occasionally asks users for feedback on videos. In one such event (the YouTube Comedy Slam), users were asked to rate which of two videos was funnier. This yielded sparse pairwise data indicating a participant's relative assessment of two videos. Given this data, several questions immediately arise: how do we make inferences for uncompared pairs, overcome noisy, and usually contradictory, data, and how do we handle severely skewed, real-world, sampling? To address these questions, we introduce the concept of a domination-graph, and demonstrate a simple and scalable method, based on the Adsorption algorithm, to efficiently propagate preferences through the graph. Before tackling the publicly available YouTube data, we extensively test our approach on synthetic data by attempting to recover an underlying, known, rank-order of videos using similarly created sparse preference data.
Experimental Validation of Nodal Aberration Theory with a Customized Ritchey–Chrétien Telescope (2016)

To experimentally validate Nodal Aberration Theory, third order spherical, coma, and astigmatism are investigated in a custom Ritchey–Chrétien telescope with precisely controlled misalignments achieved with a secondary mirror mounted on a hexapod.
Contribution of ions in radio frequency properties of atmospheric pressure microgaps (2014)

In this paper, the contribution of ions in RF permittivity and electrical conductivity of atmospheric pressure micro- and sub-microgaps in both pre-breakdown and post-breakdown regimes is investigated. It is shown that ions are ignorable in post-breakdown conditions, while their role becomes significant in pre-breakdown mode especially for gaps on the right side of Paschen's curve. Also, it is demonstrated that the contribution of ions in RF properties increases by decreasing the operating frequency in comparison with ion-neutral collision frequency.
Towards Efficient Graph Convolutional Networks for Point Cloud Handling (2021)

In this paper, we aim at improving the computational efficiency of graph convolutional networks (GCNs) for learning on point clouds. The basic graph convolution that is typically composed of a $K$-nearest neighbor (KNN) search and a multilayer perceptron (MLP) is examined. By mathematically analyzing the operations there, two findings to improve the efficiency of GCNs are obtained. (1) The local geometric structure information of 3D representations propagates smoothly across the GCN that relies on KNN search to gather neighborhood features. This motivates the simplification of multiple KNN searches in GCNs. (2) Shuffling the order of graph feature gathering and an MLP leads to equivalent or similar composite operations. Based on those findings, we optimize the computational procedure in GCNs. A series of experiments show that the optimized networks have reduced computational complexity, decreased memory consumption, and accelerated inference speed while maintaining comparable accuracy for learning on point clouds. Code will be available at \url{https://github.com/ofsoundof/EfficientGCN.git}.
Myelodysplastic/Myeloproliferative Neoplasms Unclassified (MDS/MPN-U) Overlap: Can We Alter the Natural History? (2016)

Abstract Introduction: The 2008 World Health Organization classification recognized a unique overlap category that combines features of myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN). The least well characterized of the 4 overlap diseases is a rare entity known as MDS/MPN Unclassifiable (MDS/MPN-U), comprising &lt;5% of myeloid disorders. The outcome of this subtype has been reported to be poor. The response to and impact of hypomethylating agents (HMA) on outcome is not well studied. Methods: We identified MDS/MPN-U patients within the Moffitt MDS database, baseline characteristics were reviewed, and responses to HMA utilizing IWG 2006 response criteria were assessed. The Kaplan-Meier method was applied to estimate overall survival (OS). Results: Among 127 patients with MDS/MPN-U, 62 patients received HMA treatment. There was no difference in baseline characteristics among those who received HMA or not, except that those treated with HMA were less likely to have low risk disease by IPSS, MD Anderson model or very low risk by revised IPSS (R-IPSS). Among 16 patients who had NextGen sequencing data, the 5 most common mutations were ASXL-1 (56%), TET2 (31%), JAK2 (33%), SRSF2 (25%), as well as SETBP1, DNMT3A, and EZH2(19%). The best overall response to HMA (hematological improvement [HI] or better) according to the International Working Group (IWG) 2006 criteria was 26%. Only 11 patients (low risk) underwent allogeneic stem cell transplant (allo-SCT) with no improvement or decrease in OS. The median OS was 33 months (mo). Among patients with IPSS low/int-1 risk disease, the median OS was 39 and 33 mo respectively for those treated with HMA vs. HMA untreated. (p=0.50). For Int-2/high risk IPSS, the median OS was 11 and 5 mo for those who received HMA and those who did not. (p=0.02). Based on R-IPSS the median OS for very low/low risk was 47 and 39 mo respectively for those treated with HMA and without (p=0.96), for intermediate risk, the median OS was 39 and 25 mo respectively (p 0.75), and for high and very high risk the median OS was 13 and 5 mo respectively for those treated with HMA and those who did not. (p &lt; 0.005). The median OS for patients with HI+, stable disease or progressive disease was 68, 59, and 36 mo respectively (p=0.08). Conclusions: Treatment with HMA is associated with modest improvement in OS among higher risk MDS/MPN-U, reinforcing the unmet need to improve outcomes in this group. Targeted therapy may prove to be of benefit as allo-SCT does not appear to be beneficial for patients even with low risk disease. Furthermore, these data demonstrate the need for prospective analysis of the outcomes of allo-SCT in patients with MDS/MPN-U to determine potential benefit to high risk patients. Disclosures Komrokji: Novartis: Consultancy, Speakers Bureau; Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding.
Development and application of 16S rRNA-targeted oligonucleotide probe for detection of the phosphate-accumulating bacterium microlunatus phosphovorus in an enhanced biological phosphorus removal process (1998)

A 16S rRNA-targeted oligonucletide probe (MP2) specific for the phosphate-accumulating bacterium (PAB) M. phosphovorus was designed and applied to a sludge from an enhanced biological phosphorus removal (EBPR) process. Probes specific for defined phylogenetic groups and the polyphosphate staining dye, DAPI (4′, 6-diamidino-2-phenylindol dihydrochloride) were also used to analyze the activated sludge community. M. phosphovorus was about 3% of the total bacteria in the EBPR sludge used. Proteobacteria belonging to the beta subclass were the most abundant. Many coccoid bacteria similar to M. phosphovorus were stained with DAPI. The percentage of PABs detected by DAPI stain was about 9% of the total bacteria.
Microstructure and Orientation Distribution of Aragonite Crystals in Nacreous Layer of Pearl Shells (2004)

The microstructure and orientation distribution of aragonite crystals in the nacreous layer of cultured Pteria penguin are investigated in this paper. Helical patterns formed by growth forefronts of the nacreous layer for good-quality shells are observed using a laser microscope, whereas no clear pattern is observed on the nacreous layer surfaces of bad-quality shells. The observed aragonite crystals are plate-shaped and hexagonal for both the good and bad-quality shells, in which the top and bottom faces are parallel to the (001) plane and the side faces are parallel to the {110} and (010) planes. The aragonite crystals in the nacreous layer of good-quality shells seem to be harmonically oriented along a crystallographic direction. These orientation distributions basically indicate that the (001) basal planes are parallel to the inner shell surface, and the [100] and [010] axes are oriented in almost the same direction, respectively. Some of the aragonite crystals are rotated about the c axis by approximately ±60° from the basic orientation distribution. On the other hand, the aragonite crystals of bad-quality shells seem to be randomly oriented in the nacreous layer. These orientation distributions indicate that the (001) basal planes are parallel to the inner shell surface in a similar manner as those of good-quality shells, but their [100] and [010] axes are randomly oriented about the c axis. Therefore, it is considered that such different orientation distributions result in different qualities of pearls that are developed in the shells.
2006 Association of American Physicians Presidential Address:The US's changing competitiveness in the biomedical sciences (2007)

Fellow AAP members, friends, and guests, it’s been a true pleasure serving the Association for the past 11 years, first as a Council member, then as an Officer, and this year as President. The entire 11 years has been a real honor and privilege, and also a thoroughly enjoyable experience. I’m glad to report that the organization is strong, financially stable, and moving forward, and I think this year’s meeting has been an excellent one, at least to this point. And this of course, brings me to the annual ritual of the Presidential Address.
UROLITHIASIS, ENDOUROLOGY AND LAPAROSCOPY (2001)

No AccessJournal of UrologyUROLOGICAL SURVEY: Abstracts1 Feb 2001UROLITHIASIS, ENDOUROLOGY AND LAPAROSCOPY Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1097/00005392-200102000-00099AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail References 1 : Survey of neuromuscular injuries to the patient and surgeon during urologic laparoscopic surgery. Urology2000; 55: 831. Google Scholar 1 : The efficacy and safety of synchronous bilateral extracorporeal shock wave lithotripsy. J Urol2000; 164: 644. Link, Google Scholar 2 : Simultaneous versus staged bilateral extracorporeal shock wave lithotripsy: long-term effect on renal function. J Urol1999; 162: 1591. Link, Google Scholar © 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 165Issue 2February 2001Page: 719-724 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement Loading ...
J/ψPolarization inppCollisions ats=7  TeV (2012)

The ALICE Collaboration has studied J/ψ production in pp collisions at √s=7 TeV at the LHC through its muon pair decay. The polar and azimuthal angle distributions of the decay muons were measured, and results on the J/ψ polarization parameters λ(θ) and λ(φ) were obtained. The study was performed in the kinematic region 2.5<y<4, 2<p(t)<8 GeV/c, in the helicity and Collins-Soper reference frames. In both frames, the polarization parameters are compatible with zero, within uncertainties.
A multicenter randomized controlled trial of two group education programs for fatigue in multiple sclerosis: Short- and medium-term benefits (2017)

Participation in FTC modestly improved self-reported fatigue for up to 6 months. This improvement did not differ significantly from that occurring with the control program.
Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer (2016)

Cancer cells often require glutamine for growth, thereby distinguishing them from most normal cells. Here we show that PIK3CA mutations reprogram glutamine metabolism by upregulating glutamate pyruvate transaminase 2 (GPT2) in colorectal cancer (CRC) cells, making them more dependent on glutamine. Compared with isogenic wild-type (WT) cells, PIK3CA mutant CRCs convert substantially more glutamine to α-ketoglutarate to replenish the tricarboxylic acid cycle and generate ATP. Mutant p110α upregulates GPT2 gene expression through an AKT-independent, PDK1-RSK2-ATF4 signalling axis. Moreover, aminooxyacetate, which inhibits the enzymatic activity of aminotransferases including GPT2, suppresses xenograft tumour growth of CRCs with PIK3CA mutations, but not with WT PIK3CA. Together, these data establish oncogenic PIK3CA mutations as a cause of glutamine dependency in CRCs and suggest that targeting glutamine metabolism may be an effective approach to treat CRC patients harbouring PIK3CA mutations.
Journal Reviews Should Count toward Continuing Education (2007)

Continuing education has become an important part of professional engineering registration. Most state boards require professional engineers to acquire a certain number of continuing education units CEUs or professional development hours PDHs over some specified time to maintain registration. The exact nature of the activities that count toward registration varies from state to state. An example from the Illinois rules http://www.ilga.gov/commission/jcar/admincode/068/068
Compact SEPIC converter using a GaN HEMT (2015)

The increasing demand for miniaturization in electronic devices has driven the design of compact power supplies which operate at higher switching frequencies. Gallium-nitride semiconductor switching devices are very promising for increasing the power density and efficiency of switch-mode power converters due to their high switching speed and low on-resistance relative to silicon devices. In this paper we describe a simple SEPIC converter using a normally-off hybrid GaN-on-Si cascode switch. Operating with a switching frequency around 1.5MHz, and with 100W load, the compact circuit was measured to have a conversion efficiency of 94.25%.
Novel Injectable Thermosensitive Hydrogels for Delivering Hyaluronic Acid–Doxorubicin Nanocomplexes to Locally Treat Tumors (2014)

The optimal formulations of DH700KMF-15 can increase the therapeutic efficacy of the local treatment of cancer with the potential for lymphotropic targeting to inhibit metastasis.
Supplementary Figure 7 from Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer (2023)

&lt;p&gt;PDF - 113K, Supplementary Figure S7. Oral dosing of CB-839 results in high exposure in mouse plasma and is well tolerated in immunocompromised mice.&lt;/p&gt;
Expression of voltage sensitive calcium channel (VSCC) L‐type Cav1.2 (α1C) and T‐type Cav3.2 (α1H) subunits during mouse bone development (2005)

Voltage-sensitive calcium channels (VSCCs) are key regulators of osteoblast plasma membrane Ca(2+) permeability and are under control of calcitropic hormones. Subtype specific antibodies were used to probe L-type Ca(v)1.2 (alpha(1C)) and T-type Ca(v)3.2 (alpha(1H)) subunit expression during mouse skeletal development. Commencing from E14.5 and continuing through skeletal maturity, immunoreactivity of Ca(v)1.2 (alpha(1C)) subunits was evident in regions of rapid long bone growth, including the perichondrium, periosteum, chondro-osseous junction and trabecular bones. Ca(v)3.2 (alpha(1H)) subunits appeared simultaneously and followed a similar distribution pattern. Both subunits were observed in osteoblasts and chondrocytes under high magnification. Interestingly, Ca(v)3.2 (alpha(1H)) subunits were present, but Ca(v)1.2 (alpha(1C)) subunits were absent from osteocytes. Western Blot and immunohistochemical assessment of in vitro cell culture models of osteogenesis and chondrogenesis confirmed the in vivo observations. We conclude that both L-type Ca(v)1.2 (alpha(1C)) and T-type Ca(v)3.2 (alpha(1H)) VSCCs are dynamically regulated in bones and cartilages during endochondral bone development.
Role of Qa-1b-binding receptors in the specificity of developing NK cells (2000)

NK cells acquire the ability to recognize MHC class I molecules during development. Studies with Qa-1(b) tetramers (Qa-1 tetramers) showed that nearly all NK1.1(+) cells from newborn C57BL/6 mice express Qa-1-binding receptors. Cytotoxic activity of these cells is fully inhibited by Qa-1 ligands on target cells. In contrast, neither receptors for H-2K(b) nor H-2D(b) were observed on NK1.1(+) cells from newborn mice. After birth, frequencies of Qa-1 tetramer(+)/ NK1.1(+) cells gradually decrease as the number of Ly49(+) /NK1.1(+) cells increases. Cell transfer studies showed that Qa-1 tetramer(+) cells from newborn mice do not lose expression of Qa-1 receptors, but that they further acquire expression of Ly49 molecules. Acquisition of Qa-1-binding receptors appears largely independent of host MHC class I molecules, as observed in studies using beta2-microglobulin-deficient (beta2m(-/-)) mice as well as K(b)/ D(b-/-) and K(b)/D(b)/beta2m(-/-) mice. The present results suggest that Qa-1-binding receptors play an important role in the specificity of developing NK cells, and suggest that these cells rely mainly on inhibitory receptors specific for non-classical MHC class I molecules to maintain self tolerance during the first weeks of life.
Robotic rehabilitation treatments: Realization of aquatic therapy effects in exoskeleton systems (2009)

Exoskeletons are attracting a great attention as a new means of rehabilitation devices. In such applications, control algorithms of exoskeletons are often inspired by nature for natural and effective assistance for patients. In this paper, a control algorithm is inspired by aquatic therapy. Aquatic therapy has various benefits for rehabilitation processes based on useful properties of water, e.g. buoyancy and drag. However, realization of such effects is challenged by limitations in hardware, such as mechanical impedance or impreciseness of actuator forces. Therefore, the resistive forces generated by actuators, which cause serious discomfort to patients, are precisely modeled and compensated to realize the control algorithm inspired by aquatic therapy effectively. The proposed methods are implemented in SUBAR developed by Sogang University and verified by experiments.
Highly Linear Electro-optic Polymer Based Traveling Wave MMI-fed Directional Coupler Modulator (2012)

We demonstrate an EO polymer based traveling-wave MMI-fed directional-coupler modulator. High-speed and linear operation is demonstrated with bandwidth-length product of 125GHz·cm, the 3-dB electrical bandwidth of 10GHz, and the SFDR of 110±3dB/Hz2/3.