gebhart/patrepeval huggingface dataset:
A Novel Adaptation Method for HTTP Streaming of VBR Videos over Mobile\n Networks (2015)

Recently, HTTP streaming has become very popular for delivering video over\nthe Internet. For adaptivity, a provider should generate multiple versions of a\nvideo as well as the related metadata. Various adaptation methods have been\nproposed to support a streaming client in coping with strong bandwidth\nvariations. However, most of existing methods target at constant bitrate (CBR)\nvideos only. In this paper, we present a new method for quality adaptation in\non-demand streaming of variable bitrate (VBR) videos. To cope with strong\nvariations of VBR bitrate, we use a local average bitrate as the representative\nbitrate of a version. A buffer-based algorithm is then proposed to\nconservatively adapt video quality. Through experiments, we show that our\nmethod can provide quality stability as well as buffer stability even under\nvery strong variations of bandwidth and video bitrates.\n
ChemInform Abstract: STRUCTURAL AND STEREODYNAMIC STUDIES ON MOLECULAR EARLY TRANSITION METAL DERIVATIVES. II. NIOBIUM OXYCHLORIDE‐HEXAMETHYLPHOSPHORAMIDE AND RELATED ADDUCTS (1976)

Abstract Anhand von 1 H‐NMR‐Untersuchungen bei tiefen Temperaturen sowie durch stufenweise Addition der Liganden zu NbOCl 3 werden die Strukturen der Komplexe (I) und (II) in Acetonitril, Methylenchlorid und Chloroform untersucht.
A 1.8V 30nJ adaptive program-voltage (20V) generator for 3D-integrated NAND flash SSD (2009)

Decreasing power consumption is the key design issue of SSDs. A typical SSD consists of more than 16 NAND Flash memories, DRAMs and a NAND controller. Since the NAND write performance is 10MB/s [1,2], to raise the write speed of SSD to the level of HDD, 100MB/s, 8 or more NAND chips in SSD are simultaneously programmed. As the feature size decreases, the total bitline capacitance in a chip increases beyond 200nF. If 8 or more NAND chips operate in parallel, a large current of 800mA flows to charge the bitline capacitance in a sub-30nm SSD [3]. A good strategy to decrease the power is lowering the supply voltage, V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</inf> , from 3.3 to 1.8V. Yet, at 1.8V, the power consumption of conventional charge pumps, used to generate the 20V program voltage, V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">PGM</inf> , drastically increases and the total power consumption of the NAND does not decrease, as shown in Fig. 13.2.1(a). The charge-pump area more than doubles, which increases the NAND chip area by 5 to 10%. To overcome this problem, we implement a low-power program-voltage generator (PVG) using a boost converter with an adaptive-frequency and duty-cycle (AFD) controller.
Pathological Changes in Surgically Resected Angiographically Occult Vascular Malformations after Radiation (1998)

Radiosurgery or conventional radiation therapy did not cause histologic vascular obliteration in intracranial AOVMs evaluated 1 to 10 years (mean 3.5 yr) after radiation delivery. It should be recognized that these patients are irradiation failures who may not be representative of all irradiated patients. However, recurrent bleeding from AOVMs may relate to poor radiation response in some patients.
Injection-stimulated dislocation motion in semiconductors (1976)

Misfit dislocations introduced during LPE growth are shown to act as sinks for point defects introduced by 1-MeV electron bombardment in Ga1−xAlxAs1−yPy/GaAs p+n heterojunctions. Electron-beam-stimulated dislocation motion was observed directly with in situ TEM studies on previously bombarded material. SEM measurements have correlated beam-induced defect annealing with recombination-enhanced defect motion. These results suggest that dislocation networks, which are active in the dark-line-defect degradation mode of heterostructure lasers, may form by a climb mechanism which is activated by the injection-stimulated motion of point defects.
Insights into the Iron- and Phosphorus-Induced Structural Rearrangements in Sodium Aluminoborosilicate Glasses and Their Impact on Melt Rheology and Crystallization Behavior (2022)

This paper presents an insight into the structural rearrangements induced by Fe2O3 and P2O5 in glasses designed in the Na2O–Al2O3–B2O3–SiO2 quaternary system. A suite of state-of-the-art characterization techniques, including magic angle spinning-nuclear magnetic resonance (MAS NMR) (on both iron-free and iron-containing glasses), Raman, and Mössbauer spectroscopies, have been employed to study the structural evolution of glasses as a function of the Fe2O3/Al2O3 ratio and P2O5 content over a broad composition space. It has been shown that while P2O5 tends to repolymerize the structure of Fe2O3-free glasses, it has a minimal impact on the network connectivity of iron-rich glasses. Further, there seems to exist a strong tetrahedral avoidance between AlO4 and FeO4 units in the glass structure. In P2O5-free glasses, iron tends to preferentially bond with borate and silicate units, while in the presence of P2O5, iron prefers to associate with phosphate (over borate and silicate) units in the glass structure. Finally, an attempt has been made to correlate the underlying structural descriptors with the rheological and crystallization behavior of glasses with an overarching goal to establish the composition–structure–property relationships in the investigated glass system.
Tool automation and computer vision methodologies for faster IC diagnostics (2021)

Automated data acquisition and analysis using scripting and Computer Vision (CV) allow one to perform repetitive tasks faster with higher accuracy. In this paper, we discuss techniques to automate analytical tools and several examples of advanced image processing and data analysis to provide accurate IC diagnostics.
Porous dendritic copper: an electrocatalyst for highly selective CO2 reduction to formate in water/ionic liquid electrolyte (2016)

Copper is currently extensively studied because it provides promising electrodes for carbon dioxide electroreduction. The original combination, reported here, of a nanostructured porous dendritic Cu-based material, characterized by electron microcopy (SEM, TEM) and X-ray diffraction methods, and a water/ionic liquid mixture as the solvent, contributing to CO<sub>2</sub> solubilization and activation, results in a remarkably efficient (large current densities at low overpotentials), stable and selective (large faradic yields) electrocatalytic system for the conversion of CO<sub>2</sub> into formic acid, a product with a variety of uses. These results provide new directions for the further improvement of Cu electrodes.
Elastic optical networks: The vision of the ICT project IDEALIST (2013)

&lt;p&gt;The current generation of optical networks based on a fixed wavelength grid and on fixed-rate transponders would impose relevant limitations for future transmission rates exceeding 100 Gb/s, thereby limiting the number of potential implementations and making a new generation of elastic optical networks (EON) necessary. To this regard, flexible-grid (Flexgrid) transmission and switching technologies could significantly increase both transport network scalability and flexibility. Further benefits would come from multilayer interworking mechanisms enabling direct control of bandwidth-variable transponders (BVT) based on electronic switching technologies (IP/MPLS, OTN, etc.) for optical bandwidth optimization purposes. The development of data and control plane solutions based on EONs enabling adaptive network and service interworking is the main objective of the ICT project IDEALIST. The paper describes the data plane architecture of a future EON based on the vision of the IDEALIST project.&lt;/p&gt;
ChemInform Abstract: Flash Vacuum Pyrolysis of Stabilized Phosphorus Ylides. Part 13. Extrusion of Ph3P from Sulfinyl Ylides and Reactivity of the Resulting Sulfinyl Carbenes. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Macromol. Mater. Eng. 9/2010 (2010)

Cover: The picture presents a scanning electron microscopy image of the foam structure of a glycerol-plasticized wheat gluten material that is produced by freeze drying. The insert shows an optical image of this wheat gluten foam without glycerol. Further details can be found in the article by T. O. J. Blomfeldt, R. T. Olsson, M. Menon, D. Plackett, E. Johansson, and M. S. Hedenqvist* on page 796.
Haemophilus influenzae Type f Hijacks Vitronectin Using Protein H To Resist Host Innate Immunity and Adhere to Pulmonary Epithelial Cells (2015)

The incidence of invasive Haemophilus influenzae type b (Hib) disease has significantly decreased since the introduction of an efficient vaccine against Hib. However, in contrast to Hib, infections caused by H. influenzae serotype f (Hif) are emerging. We recently did a whole genome sequencing of an invasive Hif isolate, and reported that Hif interacts with factor H by expressing protein H (PH). In this study, upon screening with various human complement regulators, we revealed that PH is also a receptor for vitronectin (Vn), an abundant plasma protein that regulates the terminal pathway of the human complement system in addition to being a component of the extracellular matrix. Bacterial Vn binding was significantly reduced when the lph gene encoding PH was deleted in an invasive Hif isolate. The dissociation constant (KD) of the interaction between recombinant PH and Vn was 2.2 μM, as revealed by Biolayer interferometry. We found that PH has different regions for simultaneous interaction with both Vn and factor H, and that it recognized the C-terminal part of Vn (aa 352-362). Importantly, PH-dependent Vn binding resulted in better survival of the wild-type Hif or PH-expressing Escherichia coli when exposed to human serum. Finally, we observed that PH mediated an increased bacterial adherence to alveolar epithelial cells in the presence of Vn. In conclusion, our study reveals that PH most likely plays an important role in Hif pathogenesis by increasing serum resistance and adhesion to the airways.
Phosphorothioate oligonucleotides can displaceNEAT1RNA and form nuclear paraspeckle-like structures (2014)

Nuclear paraspeckles are built co-transcriptionally around a long non-coding RNA, NEAT1. Here we report that transfected 20-mer phosphorothioate-modified (PS) antisense oligonucleotides (ASOs) can recruit paraspeckle proteins to form morphologically normal and apparently functional paraspeckle-like structures containing no NEAT1 RNA. PS-ASOs can associate with paraspeckle proteins, including P54nrb, PSF, PSPC1 and hnRNPK. NEAT1 RNA can be displaced by transfected PS-ASO from paraspeckles and rapidly degraded. Co-localization of PS-ASOs with P54nrb was observed in canonical NEAT1-containing paraspeckles, in perinucleolar caps upon transcriptional inhibition, and importantly, in paraspeckle-like or filament structures lacking NEAT1 RNA. The induced formation of paraspeckle-like and filament structures occurred in mouse embryonic stem cells expressing little or no NEAT1 RNA, suggesting that PS-ASOs can serve as seeding molecules to assemble paraspeckle-like foci in the absence of NEAT1 RNA. Moreover, CTN, an RNA reported to be functionally retained in paraspeckles, was also observed to localize to paraspeckle-like structures, implying that paraspeckle-like structures assembled on PS-ASOs are functional. Together, our results indicate that functional paraspeckles can form with short nucleic acids other than NEAT1 RNA.
Alternative Models of the Rotating Beam (2011)

Rotating beams are usually analyzed under a Gauss-Laguerre modal decomposition. We examine rotating beam generation and propagation from a modeling perspective, using phase-retrieval algorithms and Hamiltonian ray-tracing, adding flexibility and insight to the design process.
Processus morphogénétiques (2015)

Enseignement Cours : Longévité cérébrale Introduction générale sur la question de longévité La longévité a été abordée sous l’angle d’une instabilité et d’un renouvellement permanent des structures vivantes, aux niveaux moléculaires et cellulaires. À quoi il faut ajouter une évolution des individus modifiés dans la structure de leur chromatine et la géométrie des réseaux de neurones. Cette identification de la part d’adaptation incluse dans le vieillissement distingue les organismes qui ont u...
Abstract 150: Identification of determinants of sensitivity to AKT inhibition using breast cancer (BC) patient-derived tumor xenografts (PDX) (2017)

Abstract The antitumor activity of AKT inhibitors is being investigated for the treatment of BC with activation of the PI3K/AKT pathway. Putative predictive biomarkers that are being tested in ongoing trials are PTEN loss/mutation (mut) (around 40% of triple negative BC) and AKT1 mutation (4-5% ER+/HER2- BC). The BEECH trial is evaluating the activity of the pan-AKT1/2/3 inhibitor (AKTi) AZD5363 in combination with the antimicrotubule agent paclitaxel in HER2-negative (HER2-) metastatic BC. We aimed to identify response biomarkers to the single agent AKTi and its degree of synergy in combination with paclitaxel, using HER2- patient-derived tumor xenografts (PDX). Fifteen PDX have been established from BC patients receiving standard treatment at our Hospital, as well as from those participating in the BEECH trial, when sample was available, by implanting their tumor biopsies at baseline, on-treatment and at progression. The antitumor activity of AZD5363 as single agent and in combination with paclitaxel has been measured in these PDX. Genotyping and protein levels have been analyzed by exome sequencing, capture-based sequencing, Western blot and immunohistochemistry (IHC). AZD5363 monotherapy results in disease stabilization or tumor regression in 3 out of 15 PDX (2/9 ER-/HER2- and 1/6 ER+/HER2-). We found a positive association between high levels of pAKT S473 by Western blot and antitumor response. Interestingly, the two ER-/HER2- responding PDX harbor a PTEN frameshift mutation or gene loss concomitant with an activating mutation within the PI3K pathway (PIK3CA or PIK3R1). The ER+/HER2- PDX responder harbors an AKT1-p.E17K mutation. AZD5363 plus paclitaxel, at a clinically relevant dose, results in disease stabilization in 2/11 PDX that progress to either single agent (1/7 ER-/HER2- and 1/4 ER+/HER2-); the latter PDX being derived from the baseline tumor biopsy of a BEECH trial patient who benefited from this combination for one year. Altogether these results suggest that double-altering events in the PI3K pathway, including PTEN loss/mut and a second PI3K-pathway alteration in ER-/HER2- tumors, or AKT1-p.E17K in ER+/HER2- tumors, and consequent high pAkt S473 levels could be associated with intrinsic sensitivity to AKT inhibition. The predictive value of these alterations as determinants of response to AKTi deserves further investigation. Citation Format: Albert Gris-Oliver, Mafalda Oliveira, Marta Guzman, Olga Rodríguez, Judit Grueso, Maurizio Scaltriti, William J. Howat, J Carl Barrett, Javier Cortés, José Baselga, Gaia Schiavon, Barry R. Davies, Cristina Saura, Violeta Serra. Identification of determinants of sensitivity to AKT inhibition using breast cancer (BC) patient-derived tumor xenografts (PDX) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 150. doi:10.1158/1538-7445.AM2017-150
Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes (2008)

A strategy for targeting protein kinases with large ATP-binding sites by using bulky and rigid octahedral ruthenium complexes as structural scaffolds is presented. A highly potent and selective GSK3 and Pim1 half-sandwich complex NP309 was successfully converted into a PAK1 inhibitor by making use of the large octahedral compounds Lambda-FL172 and Lambda-FL411 in which the cyclopentadienyl moiety of NP309 is replaced by a chloride and sterically demanding diimine ligands. A 1.65 A cocrystal structure of PAK1 with Lambda-FL172 reveals how the large coordination sphere of the ruthenium complex matches the size of the active site and serves as a yardstick to discriminate between otherwise closely related binding sites.
GNSS Fault Detection and Mitigation using Android IMU (2022)

Applications of location information provided by Android devices have been expanding rapidly due its prevalence in the technology market. However, as the development focus of the Global Navigation Satellite Systems (GNSS) chipsets inside smartphones are not only accuracy, precision, and integrity, but also power consumption and size constraints, the Android GNSS hardware and software are more susceptible to signal attenuation and interference compared to high performance geodetic GNSS receivers. For example, the Android GNSS navigation engines are more vulnerable to the effects of signal multipath and experience more frequent carrier phase cycle slips in reduced GNSS signal quality environments such as urban canyons. Although standalone smartphone GNSS receivers have these limitations, some of the smartphones have access to additional sensors for accuracy and integrity support, such as accelerometers and gyroscopes. In this paper, the effectiveness of the accelerometers and gyroscopes inside Android devices, in supporting the standalone Android GNSS receivers will be investigated. The investigation will use the smartphone embedded sensors for device-independent performance that is not reliant on any other external sources of information. The additional sensors will be mixed with the GNSS measurements through a tightly-coupled extended Kalman filter, and potential faults will be flagged and mitigated using the innovation metrics. The GNSS measurements will be singled differenced to remove the effects of clock bias and drift on the filter. The orientation of the device will be determined using the accelerometer and gyroscope, and complemented using the GNSS measurements. Also, the thresholds for the innovation metrics will be computed using nominal open-sky data. The novelty of the paper will be looking at how the additional smartphone sensors can be used to improve the position solution from the smartphone, and also detect and mitigate potential faults in the GNSS measurements due to multipath or carrier phase cycle slips.
Synthesis of unlabelled and tritium labelled 4‐isothiocyanato‐1‐(1‐phenylcyclohexyl)piperidine (fourphit), tools for the study of the dopamine reuptake complex. (1992)

Abstract The synthesis of high specific activity tritium labelled 4‐isothiocyanato‐1‐(1‐phenylcyclohexyl)piperidine ([ 3 H]fourphit), a probe for the autoradiographic study of the dopamine reuptake complex, is described. An improved, facile synthesis of unlabelled fourphit in high overall yield is also presented. Detailed study of the interaction of unlabelled and tritium labelled fourphit with the dopamine reuptake complex may lead to a better understanding of the actions of cocaine.
Comparative Mapping of Canine and Human Proximal Xq and Genetic Analysis of Canine X-Linked Severe Combined Immunodeficiency (1994)

Parallel genetic analysis of animal and human genetic diseases can facilitate the identification and characterization of the causative gene defects. For example, canine X-linked severe combined immunodeficiency (SCID) is characterized by clinical, pathological, and immunological manifestations similar to the most common form of human SCID. To derive a canine syntenic map including genes that in humans are located in proximal Xq, near human X-linked SCID, poly(TG) polymorphisms were identified at the canine phosphoglycerate kinase (PGK) and choroideremia (CHM) loci. These plus a polymorphic poly(CAG) sequence in exon 1 of the canine androgen receptor gene (AR) were used to genotype members of the colony informative for X-linked SCID. No recombinations among SCIDX1, AR, PGK, or CHM were observed. Fluorescence in situ hybridization localized PGK and CHM to proximal Xq in the dog, in the same chromosomal location occupied by the human genes. Somatic cell hybrid analysis and methylation differences at AR demonstrated that female dogs carrying X-linked SCID have the same lymphocyte-limited skewed X-chromosome inactivation patterns as human carriers. These genetic and phenotypic findings provide evidence that mutations in the same gene, now identified as the gamma chain of the IL-2 receptor, cause canine and human X-linked SCID. This approach is an efficient method for comparative gene mapping and disease identification.
A comparison of the thermal resistance of a foam neoprene wetsuit to a wetsuit fabricated from aerogel-syntactic foam hybrid insulation (2006)

The purpose of this study was to compare the thermal resistance of a wetsuit fabricated from aerogel-syntactic foam hybrid insulation developed by Bardy et al [1] to a foam neoprene wetsuit. The thermal resistance of the hybrid wetsuit and a foam neoprene wetsuit was measured on a human test subject in water at 0.25 MPa (15.25 msw) of hyperbaric pressure. Measurements showed that although certain body regions of the hybrid wetsuit had a higher thermal resistance than foam neoprene, the overall thermal resistance of the hybrid wetsuit was 41% less than a foam neoprene wetsuit, and 51–88% less than predicted values. This was postulated, based on sample testing in water, to be due, in part, to increased heat flow through the hybrid insulation from water filled surface depressions at higher pressures. Other factors may have included water flow over the skin and the presence of thermal bridges in the insulation. Due to a smooth surface and tighter fit, the measured thermal resistance of the foam neoprene wetsuit was within 2–23% of the values predicted using data from Bardy et al [2]. It was concluded that unless the surface depressions can be eliminated, and alternative methods for a tighter fit achieved, foam neoprene provides more thermal protection.
A Novel Harmonic Control Method for MMC Combining Improved Nearest Level Control and Selective Harmonic Elimination method (2019)

This paper proposes a novel harmonic control method combining the improved nearest level control (NLC) and selective harmonic elimination (SHE) method. For the proposed improved NLC, it is applied on the voltage reference of the output terminals instead of the voltage reference of each arm. It has the advantages of higher control accuracy and better harmonic performance especially for the medium voltage application where the number of submodule (SM) is not high. For SHE method, it is applied in this paper to eliminate one certain harmonic by adding an additional signal pulse in each quarter wave. By combination of the two methods, one certain undesired harmonic can be eliminated while maintaining the low switching frequency of NLC. In addition, a novel hysteresis circulating current controller is introduced in this paper, which can control the circulating current, and then effectively regulate the arm energy. Compared with conventional NLC method, the proposed method provides a better harmonic performance and eliminates one certain harmonic at the price of slightly increase of the switching frequency. Moreover, since only one SHE pulse is added in a quarter wave, the additional SHE angles can be directly calculated by equation and do not require other optimal algorithm. Therefore, it can be applied online with variable modulation index. Taking the fifth order harmonic as an example, the simulation results verify the effectiveness of the proposed harmonic control method.