gebhart/patrepeval huggingface dataset:
Benign small bowel tumor. (1975)

The clinical record and histologic sections of 84 cases of benign small bowel tumor are reviewed. Manifestations of systemic diseases, congenital anomalies, and lesions of either the ileocecal valve or periampullary region were excluded. In the same time span there were 96 small bowel malignancies. Clinical presentation, pathologic findings, management and result are compared to the collected published experience of about 2000 cases. There were 36 leiomyomas, 22 lipomas, 9 angiomas, 6 neurofibromas and 4 fibromas. Thirty-six men and 48 women were affected; the majority in their fifth and sixth decade. Seventy-eight were operative and 6 autopsy diagnoses. The most common symptom was obstruction (42%) followed by hemorrhage (34%) and pain (22%), relative frequency differing for the various specific tumors. There were rarely significant physical findings. A diagnosis of small bowel tumor was made radiologically in 30 patients. Because of the nonspecificity of other signs and symptoms, an acute awareness of the possibility of small bowel tumor is mandatory for preoperative anticipation of the diagnosis. Local resection was performed in all with no deaths or significant postoperative complications.
Supplementary Figure 3 from AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer (2023)

&lt;p&gt;Supplementary Figure 3 Evaluation of DLL3 expression in tumor types other than SCLC.&lt;/p&gt;
Hardware implementation of a real-time 3D video acquisition system (2010)

An implementation of a real-time 3D video acquisition system on a single FPGA is presented. Our approach is based on the use of stereo image sensors and can display real-time 3D video when combined with shutter glasses. The 3D effect is generated based on the parallax of the stereo sensors. An overview of the system architecture is given, including some details of the FPGA implementation of actual image processing pipeline. This architecture provides the basis for a low-cost, personal 3D imaging appliance.
Aqueous Processable Portable Conformable Mask (PCM) for Submicron Lithography (1988)

To overcome the interfacial residues of the novolak resist/polymethylmethacrylate portable conformable mask (PCM), an underlayer of a terpolymer of poly (methylmethacrylate methacrylic acid‐methacrylic acid anhydride) was used in conjunction with an aqueous alkaline developer. The results reported show the submicron resolution capability of a simple capped process which uses a low toxicity aqueous developer which overcomes the interfacial scumming of the two resist layers in the novolak/PMMA‐PCM. In addition, the thermal stability of the underlayer is enhanced by the copolymerization of cyclic anhydride groups into the PMMA polymer structure.
Mitochondrial genome undergoes de novo DNA methylation that protects mtDNA against oxidative damage during the peri-implantation window (2022)

Mitochondrial remodeling during the peri-implantation stage is the hallmark event essential for normal embryogenesis. Among the changes, enhanced oxidative phosphorylation is critical for supporting high energy demands of postimplantation embryos, but increases mitochondrial oxidative stress, which in turn threatens mitochondrial DNA (mtDNA) stability. However, how mitochondria protect their own histone-lacking mtDNA, during this stage remains unclear. Concurrently, the mitochondrial genome gain DNA methylation by this stage. Its spatiotemporal coincidence with enhanced mitochondrial stress led us to ask if mtDNA methylation has a role in maintaining mitochondrial genome stability. Herein, we report that mitochondrial genome undergoes de novo mtDNA methylation that can protect mtDNA against enhanced oxidative damage during the peri-implantation window. Mitochondrial genome gains extensive mtDNA methylation during transition from blastocysts to postimplantation embryos, thus establishing relatively hypermethylated mtDNA from hypomethylated state in blastocysts. Mechanistic study revealed that DNA methyltransferase 3A (DNMT3A) and DNMT3B enter mitochondria during this process and bind to mtDNA, via their unique mitochondrial targeting sequences. Importantly, loss- and gain-of-function analyses indicated that DNMT3A and DNMT3B are responsible for catalyzing de novo mtDNA methylation, in a synergistic manner. Finally, we proved, in vivo and in vitro, that increased mtDNA methylation functions to protect mitochondrial genome against mtDNA damage induced by increased mitochondrial oxidative stress. Together, we reveal mtDNA methylation dynamics and its underlying mechanism during the critical developmental window. We also provide the functional link between mitochondrial epigenetic remodeling and metabolic changes, which reveals a role for nuclear-mitochondrial crosstalk in establishing mitoepigenetics and maintaining mitochondrial homeostasis.
Sensing of chemical vapor using a porous multilayer prepared from lightly doped silicon (2007)

Abstract A porous silicon rugate filter was prepared and investigated for its ability to sense ethanol vapors of different concentrations. The structure shows sensitivity to concentrations above 1% in volume up to saturation at room temperature. This sensitivity is in the form of a red shift of the characteristic peak of the filter due to capillary condensation phenomenon. Exposing the structure to saturated ethanol vapor produces partial filling of the pores with liquid. Theoretical calculations using the Bruggeman effective medium approximation and characteristic matrix method were employed to estimate the average volume fraction of ethanol molecules condensed into the pores. Electrochemical oxidation of the filter was performed. Furthermore, the oxidized structure was found to improve the durability of the filter and increase the adsorbed amount of ethanol molecules into the pores. (© 2007 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Mining communities and health risks (1993)

Journal Article Mining communities and health risks Get access Anna Barrettm, Anna Barrettm Clinical Nurse Specialist King's Mill HospitalNottinghamshire Search for other works by this author on: Oxford Academic PubMed Google Scholar Rosemary Gillespie Rosemary Gillespie Senior Lecturer in Health Studies School of Social and Historical Studies, University of PortsmouthMilldam, Burnaby Rd, Portsmouth POI 3AS Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Public Health, Volume 15, Issue 3, September 1993, Pages 291–293, https://doi.org/10.1093/oxfordjournals.pubmed.a042868 Published: 01 September 1993
Quantitative analysis of RNA produced by slow and fast alleles of Adh in Drosophila melanogaster. (1988)

The alcohol dehydrogenase (ADH) locus (Adh) of Drosophila melanogaster in polymorphic on a world-wide basis for two allozymes, Fast and Slow. This study was undertaken to determine whether the well-established difference in ADH protein concentration between the allozymes is due to a difference in mRNA levels. RNA gel blot hybridization and an RNase protection assay were used to quantify ADH mRNA levels. Each method used an Adh null mutant as an internal standard. Several Slow and Fast allele pairs of different geographic origins were analyzed. The results provide strong evidence that the ADH protein concentration difference is not accounted for by RNA level.
SIZE OF SOURCE EFFECT OF A TRANSFER REFERENCE THERMOMETER SUITABLE FOR INTERNATIONAL COMPARISONS NEAR TO ROOM TEMPERATURE (2009)

Abstract − We measured the size-of-source-effect (SSE) of a transfer reference thermometer (TRT) for the lowtemperature mode with the spectral range from 8 μm to 14 μm by using the direct method. The measurements were carried out for various blackbody temperatures from 10 °C to 300 °C. The size of source changed from 10 mm to 80 mm in diameter. Taking the radiation from the masked area of the aperture plate and its surroundings into account, we observed that the SSE curves measured at various temperatures overlaps well. The SSE functions show a twostep saturation behaviour unusually. Excluding the data obtained near the room temperature, the values of the SSE functions agrees within 0.05 %.
Two-Timescale Voltage Control in Distribution Grids Using Deep Reinforcement Learning (2019)

Modern distribution grids are currently being challenged by frequent and sizable voltage fluctuations, due mainly to the increasing deployment of electric vehicles and renewable generators. Existing approaches to maintaining bus voltage magnitudes within the desired region can cope with either traditional utility-owned devices (e.g., shunt capacitors), or contemporary smart inverters that come with distributed generation units (e.g., photovoltaic plants). The discrete on-off commitment of capacitor units is often configured on an hourly or daily basis, yet smart inverters can be controlled within milliseconds, thus challenging joint control of these two types of assets. In this context, a novel two-timescale voltage regulation scheme is developed for distribution grids by judiciously coupling data-driven with physicsbased optimization. On a faster timescale, say every second, the optimal setpoints of smart inverters are obtained by minimizing instantaneous bus voltage deviations from their nominal values, based on either the exact alternating current power flow model or a linear approximant of it; whereas, on the slower timescale (e.g., every hour), shunt capacitors are configured to minimize the longterm discounted voltage deviations using a deep reinforcement learning algorithm. Extensive numerical tests on a real-world 47- bus distribution network as well as the IEEE 123-bus test feeder using real data corroborate the effectiveness of the novel scheme.
HIGH-EFFICIENCY MQW ELECTROABSORPTION MODULATORS (2002)

Multi-quantum well (MQW) electroabsorption modulators (EAMs) are attractive for applications requiring signal modulation at high speed and with high efficiency (high extinction ratio at low voltage). They are promising devices for external signal mod-ulation in high-bandwidth optical communication systems. EAMs can be integrated with other devices like laser diodes, semiconductor optical amplifiers, and mode trans-formers. We have fabricated InGaAsP/InP multi-quantum well EAMs with a band-width above 25 GHz and with up to 35dB/V extinction efficiency. We analyze the transmission performance of our modulator in detail and identify optimum operation conditions. 1.
Unfolding Neural Networks for Compressive Multichannel Blind Deconvolution (2021)

We propose a learned-structured unfolding neural network for the problem of compressive sparse multichannel blind-deconvolution. In this problem, each channel’s measurements are given as convolution of a common source signal and sparse filter. Unlike prior works where the compression is achieved either through random projections or by applying a fixed structured compression matrix, this paper proposes to learn the compression matrix from data. Given the full measurements, the proposed network is trained in an unsupervised fashion to learn the source and estimate sparse filters. Then, given the estimated source, we learn a structured compression operator while optimizing for signal reconstruction and sparse filter recovery. The efficient structure of the compression allows its practical hardware implementation. The proposed neural network is an autoencoder constructed based on an unfolding approach: upon training, the encoder maps the compressed measurements into an estimate of sparse filters using the compression operator and the source, and the linear convolutional decoder reconstructs the full measurements. We demonstrate that our method is superior to classical structured compressive sparse multichannel blind-deconvolution methods in terms of accuracy and speed of sparse filter recovery.
CO2-Reservoir Oil Miscibility: Experimental and Non-experimental Characterization and Determination Approaches (2018)

Fundamentals of CO2-Oil Miscibility -- Needs to Determine CO2-Oil Minimum Miscibility Pressure (MMP) -- Analytical MMP Determination Methods -- Experimental MMP Determination Methods -- Computational MMP Determination Methods -- Advantages, Disadvantages, and Limitations of Various Methods -- Emerging CO2-Oil MMP Determination Approaches.
Data from Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-Producing Dendritic Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;Macrophages often abound within tumors, express colony-stimulating factor 1 receptor (CSF1R), and are linked to adverse patient survival. Drugs blocking CSF1R signaling have been used to suppress tumor-promoting macrophage responses; however, their mechanisms of action remain incompletely understood. Here, we assessed the lung tumor immune microenvironment in mice treated with BLZ945, a prototypical small-molecule CSF1R inhibitor, using single-cell RNA sequencing and mechanistic validation approaches. We showed that tumor control was not caused by CSF1R&lt;sup&gt;+&lt;/sup&gt; cell depletion; instead, CSF1R targeting reshaped the CSF1R&lt;sup&gt;+&lt;/sup&gt; cell landscape, which unlocked cross-talk between antitumoral CSF1R&lt;sup&gt;−&lt;/sup&gt; cells. These cells included IFNγ-producing natural killer and T cells, and an IL12-producing dendritic cell subset, denoted as DC&lt;sub&gt;3&lt;/sub&gt;, which were all necessary for CSF1R inhibitor–mediated lung tumor control. These data indicate that CSF1R targeting can activate a cardinal cross-talk between cells that are not macrophages and that are essential to mediate the effects of T cell–targeted immunotherapies and promote antitumor immunity.&lt;/p&gt;&lt;p&gt;&lt;a href="https://cancerimmunolres.aacrjournals.org/content/early/2021/12/15/2326-6066.CIR-21-0977" target="_blank"&gt;&lt;i&gt;See related Spotlight by Burrello and de Visser, p. 4&lt;/i&gt;&lt;/a&gt;.&lt;/p&gt;&lt;/div&gt;
IS THIRD RENAL TRANSPLANTATION WORKING, IS IT SAFE? (2008)

You have accessJournal of Urology1 Apr 2008IS THIRD RENAL TRANSPLANTATION WORKING, IS IT SAFE? Federico Sallusto, Marc Mouzin, Xavier Game, Nicolas Doumerc, Nassim Kamar, Lionel Rostaing, Dominique Durand, Jean P Sarramon, Bernard Malavaud, and Pascal Rischmann Federico SallustoFederico Sallusto More articles by this author , Marc MouzinMarc Mouzin More articles by this author , Xavier GameXavier Game More articles by this author , Nicolas DoumercNicolas Doumerc More articles by this author , Nassim KamarNassim Kamar More articles by this author , Lionel RostaingLionel Rostaing More articles by this author , Dominique DurandDominique Durand More articles by this author , Jean P SarramonJean P Sarramon More articles by this author , Bernard MalavaudBernard Malavaud More articles by this author , and Pascal RischmannPascal Rischmann More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)62020-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "IS THIRD RENAL TRANSPLANTATION WORKING, IS IT SAFE?." The Journal of Urology, 179(4S), p. 692 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 692 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Federico Sallusto More articles by this author Marc Mouzin More articles by this author Xavier Game More articles by this author Nicolas Doumerc More articles by this author Nassim Kamar More articles by this author Lionel Rostaing More articles by this author Dominique Durand More articles by this author Jean P Sarramon More articles by this author Bernard Malavaud More articles by this author Pascal Rischmann More articles by this author Expand All Advertisement PDF downloadLoading ...
(S)‐Selective Kinetic Resolution and Chemoenzymatic Dynamic Kinetic Resolution of Secondary Alcohols (2005)

(S)-Selective kinetic resolution was achieved through the use of a commercially available protease, which was activated with a combination of two different surfactants. The kinetic resolution (KR) process was optimized with respect to activation of the protease and to the acyl donor. The KR proved to be compatible with a range of functionalized sec-alcohols, giving good to high enantiomeric ratio values (up to >200). The enzymatic resolution was combined with a ruthenium-catalyzed racemization to give an (S)-selective dynamic kinetic resolution (DKR) of sec-alcohols. The DKR process works under very mild reaction conditions to give the corresponding esters in high yields and with excellent enantioselectivities.
Monoclonal Origin of Multicentric Kaposi's Sarcoma Lesions (1997)

These data indicate that Kaposi's sarcoma is a disseminated monoclonal cancer and that the changes that permit the clonal outgrowth of spindle cells occur before the disease spreads.
Stripping Voltammetry of Cu Overlayers Deposited on Self-Assembled Monolayers:  Field Emission of Electrons through A Phenylene Ethynylene Oligomer (2000)

Copper overlayers were formed on electrodes coated with self-assembled monolayers (SAMs) of a molecular wire candidate, 1-thio-4-[4‘-[(4‘-thio)phenylethynyl]-1‘-ethynyl]-2‘,5‘-(diethyl)phenylbenzene (TTEB), by electrochemical reduction of copper ions and by physical vapor deposition. Anodic stripping voltammetry of copper was employed to study the electrochemical and electron transport properties of SAMs of these molecules. Electrochemical copper deposition revealed that SAMs of TTEB passivate the electrode to electrochemistry in a manner similar to alkanethiols. Migration of copper ions trapped within the TTEB SAM after copper oxidation was also observed. Reduction of the solvent prevented the application of a sufficient potential to deposit copper by conduction through the TTEB SAM, so evaporation of copper metal was employed to coat the entire electrode. Anodic stripping voltammetry first removed the metal from defect sites, leaving behind copper islands connected to the gold by TTEB molecules. At higher potentials the copper islands were oxidized via electron transport through the TTEB SAM. A barrier height of 1.17 eV to charge injection was calculated from the tunneling current and overpotential by a Fowler−Nordheim-type analysis. Tunneling currents in TTEB molecules with metal contacts were found to be dominated by hole transport.
Rigid Amphiphiles for Membrane Protein Manipulation (2000)

Zwei nicht homologe Membranproteine, Bacteriorhodopsin und Rhodopsin aus Rindern, können mit Hilfe des „Dreifuß”︁-Amphiphils 1 aus den jeweiligen Membranen extrahiert werden. Beide Proteine bleiben in einer stabilen, löslichen Form erhalten, eine unbedingte Voraussetzung für die Kristallisation. Amphiphile dieses neuen Typs lassen sich leicht modifizieren und sind sehr nützlich für die Manipulation von Membranproteinen.
Detection of Heavy Metal Ions in Water by High-Resolution Surface Plasmon Resonance Spectroscopy Combined with Anodic Stripping Voltammetry (2007)

High-resolution differential surface plasmon resonance (SPR) with anodic stripping voltammetry (ASV) capability has been demonstrated for detecting heavy metal ions in water. Metal ions are electroplated onto the gold SPR sensing surface and are quantitatively detected by stripping voltammetry. Both the SPR angular shift and electrochemical current signal are recorded to identify the type and amount of the metal ions in water. The performance of the combined approach is further enhanced by a differential detection approach. The gold sensor surface is divided into a reference and a sensing area, and the difference in the SPR angles from the two areas is detected with a quadrant cell photodetector as a differential signal. Our system demonstrated quantitative detection of copper, lead, and mercury ions in water from part-per-million to sub-part-per-billion levels with good linearity.
Effect of Preheating on Creep Properties of Substrate Coated by Low Pressure Plasma Spraying. (1995)

The effect of preheating on rupture properties of substrate coated by low pressure plasma spraying was investigated in this study. Creep-rupture specimens of Ni-base superalloy, Mar-M247 were coated after preheating at several temperature ranges. Especially, a relationship between preheating temperature and microstructures of sprayed substrates was discussed. The results are summarized as follows.(1) Creep properties of Mar-M247, as a substrate, coated with CoCrA1Y were kept at the level of as cast material when preheated at the range of 1073-1173 K in low pressure plasma spraying.(2) The substrates of specimen coated after preheated at the range of 1473-1573 K were severely damaged in rupture life, strain and reduction of area. It is considered that liquation induced by high preheating in low pressure plasma spraying should occur and grow on the solidification grain boundaries of substrate. Consequently, creep properties were deteriorated, because of opening the grain boundaries during cooling period.(3) The mechanism of liquation and opening on the grain boundaries was deduced as the following. At first, selective decomposition of tungsten carbide in complex carbides is brought by heat. Simultaneously, carbon is dissolved around the grain boundaries which is one of elements decreasing melting point. After spraying, cooling shrinkage makes opening of solidification grain boundaries.
Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model (2013)

Casein kinase II (CK2) inhibitors suppress cancer cell growth. In this study, we examined the inhibitory effects of a novel CK2 inhibitor, hematein, on tumor growth in a murine xenograft model. We found that in lung cancer cells, hematein inhibited cancer cell growth, Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increased apoptosis. In a murine xenograft model of lung cancer, hematein inhibited tumor growth without significant toxicity to the mice tested. Molecular docking showed that hematein binds to CK2α in durable binding sites. Collectively, our results suggest that hematein is an allosteric inhibitor of protein kinase CK2 and has antitumor activity to lung cancer.