gebhart/patrepeval huggingface dataset:
Tuning the Potential of Electron Extraction from Microbes with Ferrocene‐Containing Conjugated Oligoelectrolytes (2018)

Synthetic systems that facilitate electron transport across cellular membranes are of interest in bio-electrochemical technologies such as bio-electrosynthesis, waste water remediation, and microbial fuel cells. The design of second generation redox-active conjugated oligoelectrolytes (COEs) bearing terminal cationic groups and a π-delocalized core capped by two ferrocene units is reported. The two COEs, DVFBO and F<sub>4</sub> -DVFBO, have similar membrane affinity, but fluorination of the core results in a higher oxidation potential (422 ± 5 mV compared to 365 ± 4 mV vs Ag/AgCl for the neutral precursors in chloroform). Concentration-dependent aggregation is suggested by zeta potential measurements and confirmed by cryogenic transmission electron microscopy. When the working electrode potential (E<sub>CA</sub> ) is poised below the oxidation potential of the COEs (E<sub>CA</sub> = 200 mV) in three-electrode electrochemical cells containing Shewanella oneidensis MR-1, addition of DVFBO and F<sub>4</sub> -DVFBO produces negligible biocurrent enhancement over controls. At E<sub>CA</sub> = 365 mV, DVFBO increases steady-state biocurrent by 67 ± 12% relative to controls, while the increase with F<sub>4</sub> -DVFBO is 30 ± 5%. Cyclic voltammetry supports that DVFBO increases catalytic biocurrent and that F<sub>4</sub> -DVFBO has less impact, consistent with their oxidation potentials. Overall, electron transfer from microbial species is modulated via tailoring of the COE redox properties.
Does Error-Diffusion Halftone Texture Mask Banding? (1998)

One type of common printer banding artifact is a thin white horizontal line. This can result from a clogged ink jet nozzle, from paper-feed problems in electrophotographic printers, and from other causes. The halftone texture might be expected to mask the visibility of the line, so a line on a strong texture might be less visible than a line on a uniform field. To test this hypothesis, white lines were printed on fields with different texture contrasts, and we measured the threshold visibility for detecting the line.The line was printed as a reflectance increment in one of the pixel-rows of an error-diffusion pattern. The error diffusion-pattern was produced by applying the Floyd and Steinberg algorithm to a gray square. Two experiments were conducted. In one experiment, only the contrast of the halftone pattern was varied, and the subject was required to detect the pattern. In the second experiment, both the contrast of the halftone pattern and the contrast of the line were varied, and the subject was required to detect the line. The threshold for detecting the line was then plotted as a function of the strength of the halftone.It was found that the error-diffusion halftone pattern does not mask sensitivity to a line until the halftone pattern was many times above its own detection strength. Even when the halftone pattern was at the highest contrast that could be printed (about 20 times threshold contrast), the threshold amplitude for detecting the line was only doubled. Error diffusion is typically used because it reduces the visibility of the halftone texture. Since only very strong halftone textures provided any visual masking, the contrast of the error diffusion texture had to be very high to obtain any significant masking effect. This has the unfortunate implication that objectionable banding may only be hidden with even more objectionable halftone texture. Some of the implications for modeling band visibility will be discussed. It is important to note that there are previously described halftone patterns that can physically reduce the amplitude of the bands, and the present result does not run counter to these findings.
NoCloud: Exploring Network Disconnection through On-Device Data Analysis (2018)

Application developers often advocate uploading data to the cloud for analysis or storage, primarily due to concerns about the limited computational capability of ubiquitous devices. Today, however, many such devices can still effectively operate and execute complex algorithms without reliance on the cloud. The authors recommend prioritizing on-device analysis over uploading the data to another host, and if on-device analysis is not possible, favoring local network services over a cloud service.
p16INK4a immunohistochemistry is a promising biomarker to predict the outcome of low grade cervical intraepithelial neoplasia: comparison study with HPV genotyping (2013)

p16(INK4a) overexpression was correlated with the outcome of CIN 1-2, and p16(INK4a) is considered to be a superior biomarker for predicting the outcome of CIN 1-2 compared with HPV genotyping.
Method of Trend Extraction Using Singular Spectrum Analysis (2022)

The paper presents a new method of trend extraction in the framework of the Singular Spectrum Analysis (SSA) approach. This method is easy to use, does not need specification of models of time series and trend, allows to extract trend in the presence of noise and oscillations and has only two parameters (besides basic SSA parameter called window length). One parameter manages scale of the extracted trend and another is a method specific threshold value. We propose procedures for the choice of the parameters. The presented method is evaluated on a simulated time series with a polynomial trend and an oscillating component with unknown period and on the seasonally adjusted monthly data of unemployment level in Alaska for the period 1976/01– 2006/09.
Carney complex: an update (2015)

Carney complex (CNC) is a rare autosomal dominant syndrome, characterized by pigmented lesions of the skin and mucosa, cardiac, cutaneous and other myxomas and multiple endocrine tumors. The disease is caused by inactivating mutations or large deletions of the PRKAR1A gene located at 17q22-24 coding for the regulatory subunit type I alpha of protein kinase A (PKA) gene. Most recently, components of the complex have been associated with defects of other PKA subunits, such as the catalytic subunits PRKACA (adrenal hyperplasia) and PRKACB (pigmented spots, myxomas, pituitary adenomas). In this report, we review CNC, its clinical features, diagnosis, treatment and molecular etiology, including PRKAR1A mutations and the newest on PRKACA and PRKACB defects especially as they pertain to adrenal tumors and Cushing's syndrome.
Conflict of Interest from NY-ESO-1 DNA Vaccine Induces T-Cell Responses That Are Suppressed by Regulatory T Cells (2023)

Conflict of Interest from NY-ESO-1 DNA Vaccine Induces T-Cell Responses That Are Suppressed by Regulatory T Cells
Unravelling the Influence of Oxygen on the Degradation Mechanisms of Fe-N-C Oxygen Reduction Reaction Catalysts in PEMFC Cathode (2022)

International audience
Supporting Multitasking in Video Conferencing using Gaze Tracking and On-Screen Activity Detection (2016)

The use of videoconferencing in the workplace has been steadily growing. While multitasking during video conferencing is often necessary, it is also viewed as impolite and sometimes unacceptable. One potential contributor to negative attitudes towards such multitasking is the disrupted sense of eye contact that occurs when an individual shifts their gaze away to another screen, for example, in a dual-monitor setup, common in office settings. We present an approach to improve a sense of eye contact over videoconferencing in dual-monitor setups. Our approach uses computer vision and desktop activity detection to dynamically choose the camera with the best view of a user's face. We describe two alternative implementations of our solution (RGB-only, and a combination of RGB and RGB-D cameras). We then describe results from an online experiment that shows the potential of our approach to significantly improve perceptions of a person's politeness and engagement in the meeting.
Computer Simulation of an LHR DI Diesel Engine (1988)

&lt;div class="htmlview paragraph"&gt;The effect on engine performance of insulating combustion chambers was simulated for a turbocharged direct injection diesel engine. We developed a low heat rejection (LHR) diesel cycle simulation. It includes a gas flow model, a heat transfer model, and a two zone combustion model. In the heat transfer model, convective and radiation heat transfer between the gas and walls was computed, taking into account the combustion chamber surface temperature swings. In the combustion model's combustion zone, the temperature and the chemical equilibrium compositions were determined. They were used to calculate the NO formation rate by assuming a modified Zeldvich mechanism. The combustion zone temperature was also used to estimate the radiation heat transfer. Simulations were performed of various combustion chamber surface materials and various LHR levels. The factors which affect thermal efficiency and exhaust emissions were deduced and their influences discussed.&lt;/div&gt;
Ultra-high resolution video rate in vivo retinal imaging with Spectral Domain Optical Coherence Tomography (2004)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. F. de Boer, B. Cense, N. Nassif, A. Yun, B. H. Park, M. P. Pierce, B. E. Bouma, G. J. Tearney, and T. C. Chen, "Ultra-high resolution video rate in vivo retinal imaging with Spectral Domain Optical Coherence Tomography," in Biomedical Topical Meeting, OSA Technical Digest (Optica Publishing Group, 2004), paper FA6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
An early-phase study of azacitidine and lenalidomide for untreated elderly acute myeloid leukemia (AML) patients. (2010)

TPS280 Background: Induction therapy results in suboptimal outcomes in elderly AML patients (pts). CpG hypermethylation of tumor suppressor gene (TSG) promoters can reduce expression and contribute to these poor outcomes. Azacitidine (aza) prevents DNA methyltransferase from methylating CpG cytosines, allowing transcription of previously silenced genes. Lenalidomide (len), an immunomodulatory agent, upregulates SPARC, a hypermethylated TSG with reduced expression in AML (Pellagatti A, et al. PNAS USA. 2007;104:11406). In addition, len was recently shown to activate demethylation of the promoter histone of p21, allowing expression of this TSG (Escoubet-Lozach L, et al. Cancer Res. 2009;69:7347). Therefore, we hypothesize that the low-intensity combination of aza and len will be a well-tolerated, mechanistically logical regimen that can synergistically upregulate TSG expression in elderly AML pts. Methods: Pts ≥60 with newly diagnosed untreated AML are eligible. In phase I, cohort 1 receives 75 mg/m2 aza SC/IV on days 1-7. After 3 weeks off, pts receive the same dose and schedule of aza, plus len, 5 mg PO on days 8-28 of a 42-day cycle. Cohorts 2, 3, and 4 receive 10, 25, and 50 mg of len, respectively, with the same dose and schedule of aza, for 42-day cycles. Once the maximum tolerated dose (MTD) is determined, the MTD cohort will roll over to an expanded phase II efficacy study. Sub-MTD cohort pts may continue at the same dose if they respond and tolerate the regimen. Pts may receive a maximum of 12 cycles. Disease assessments in both phases occur after cycles 1, 3, 6, and 12 by bone marrow biopsy. Using a Simon two-stage design with α= 0.05, power= 0.8, null hypothesis=20% complete remission (CR) (based on reports of use of aza alone) and alternative hypothesis=40% CR, phase II requires 33 pts. The primary endpoints for phase I and II are MTD and CR rate, respectively. Correlative studies to identify molecular features that predict responsiveness, including investigations of Cdc25C and PP2Acα phosphatase expression, TET2 mutations, and genome expression profiling, are planned. As of January 1, 11 pts, 6 with secondary AML, have enrolled in phase I (5, 3, and 3 in cohorts 1, 2, and 3), receiving a median of 2 cycles. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Celgene Celgene
Integrating III-V on Silicon for Future Nanoelectronics (2008)

This paper describes about III-V integration on silicon and summarizes the recent progress on the research efforts to combine the merits of III-V and silicon, on the same silicon wafer, for future high-speed and low-power nanoelectronics. The successful integration of III-V on silicon can open up opportunities for integrating new functionalities and features on silicon, such as integrating logic, optoelectronic and communication platforms on the same Si wafer.
Antibody Targeting of Camptothecin-Loaded PLGA Nanoparticles to Tumor Cells (2008)

Antibody targeting of drug substances can improve the efficacy of the active molecule, improving distribution and concentration of the drug at the site of injury/disease. Encapsulation of drug substances into polymeric nanoparticles can also improve the therapeutic effects of such compounds by protecting the molecule until its action is required. In this current study, we have brought together these two rationales to develop a novel immuno-nanoparticle with improved therapeutic effect against colorectal tumor cells. This nanoparticle comprised a layer of peripheral antibodies (Ab) directed toward the Fas receptor (CD95/Apo-1) covalently attached to poly(lactide-co-glycolide) nanoparticles (NP) loaded with camptothecin. Variations in surface carboxyl density permitted up to 48.5 microg coupled Ab per mg of NP and analysis of nanoparticulate cores showed efficient camptothecin loading. Fluorescence visualization studies confirmed internalization of nanoconstructs into endocytic compartments of HCT116 cells, an effect not evident in NP without superficial Ab. Cytotoxicity studies were then carried out against HCT116 cells. After 72 h, camptothecin solution resulted in an IC 50 of 21.8 ng mL (-1). Ab-directed delivery of NP-encapsulated camptothecin was shown to be considerably more effective with an IC 50 of 0.37 ng mL (-1). Calculation of synergistic ratios for these nanoconstructs demonstrated synergy of pharmacological relevance. Indeed, the results in this paper suggest that the attachment of anti-Fas antibodies to camptothecin-loaded nanoparticles may result in a therapeutic strategy that could have potential in the treatment of tumors expressing death receptors.
Quantifying Bulk and Surface Recombination in CdTe Solar Cells Using Time-Resolved Terahertz Spectroscopy (2021)

Understanding the nature of recombination mechanisms is essential for higher power conversion efficiency in photovoltaic (PV) devices. Here we use a combination of time-resolved terahertz spectroscopy and numerical modeling to determine the bulk Shockley-Read-Hall lifetime and interface and back surface recombination velocities in CdTe thin film stacks. The measurement was facilitated by fabricating wire-grid device structures using conventional laser scribing. Evaluation of a glass/FTO/SnO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> /CdS/CdTe stack treated with CdCl <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> allowed separation of the CdTe absorber bulk lifetime, 1.6 ns, from the back surface recombination velocity, ~6x10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> cm/s, and indicated that CdTe/CdS interface recombination velocity had no significant impact on carrier dynamics.
Determinants of Left Ventricular Mass in Patients on Hemodialysis (2012)

Frequent in-center hemodialysis reduces LVM. The benefit of frequent hemodialysis on LVM may be mediated by salutary effects on blood pressure. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00264758.
InGaAsP monolithic extended-cavity lasers with integrated saturable absorbers for active, passive, and hybrid mode locking at 8.6 GHz (1993)

Active, passive, and hybrid mode locking of a monolithic extended-cavity semiconductor laser with an integrated saturable absorber have been demonstrated. Actively mode locked at a repetition rate of 8.6 GHz, 6.2 ps pulses were measured. Hybrid mode locking resulted in 4.4 ps pulses. The extended-cavity laser also exhibits self-starting passive mode locking at a repetition rate of 8.57 GHz with 5.5 ps pulses. A broad spectrum allows wavelength selectivity over a range of 15 nm with little change in the pulse width.
Langmuir–Blodgett films of side-chain polysiloxanes: synthesis, characterisation and pyroelectric behaviour (1992)

Four aliphatic acid side-chain polymers have been synthesized and evaluated, based upon two different polysiloxane backbones, namely poly(methylsiloxane) and poly(methylsiloxane–dimethylsiloxane). A study of their behaviour at the water/air interface has shown that stable, fluid molecular films are formed that can be transferred as monolayers onto hydrophilic substrates. Their surface pressure–area isotherms indicate that bunching of the polysiloxane backbones may occur at relatively high surface pressures. The alternate layer deposition process has been used, in which the polysiloxane is co-deposited with a monomeric aliphatic amine (icosylamine). This ABABA⋯ sequential transfer has been monitored using the piezoelectric quartz crystal microgravimetric technique in which the alternate layer is assembled on top of a bulk quartz crystal, the oscillation frequency of which is measured precisely. The relationship between the frequency change and the number of transferred polysiloxane/monomer icosylamine bilayers is linear for the three materials that could be deposited, indicating that the deposition process is highly reproducible. The pyroelectric effect in these films has been studied. These data indicate that the level of activity is not simply related to the fraction of the silicon units along the backbones which are substituted with aliphatic acid chains. There is likely to be a trade-off between the density of acid/amine interactions and the free volume in which molecular tilting can occur.
Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements (2020)

The trimeric HIV-1 Envelope protein (Env) mediates viral-host cell fusion via a network of conformational transitions, with allosteric elements in each protomer orchestrating host receptor-induced exposure of the co-receptor binding site and fusion elements. To understand the molecular details of this allostery, here, we introduce Env mutations aimed to prevent CD4-induced rearrangements in the HIV-1 BG505 Env trimer. Binding analysis and single-molecule Förster Resonance Energy Transfer confirm that these mutations prevent CD4-induced transitions of the HIV-1 Env. Structural analysis by single-particle cryo-electron microscopy performed on the BG505 SOSIP mutant Env proteins shows rearrangements in the gp120 topological layer contacts with gp41. Displacement of a conserved tryptophan (W571) from its typical pocket in these Env mutants renders the Env insensitive to CD4 binding. These results reveal the critical function of W571 as a conformational switch in Env allostery and receptor-mediated viral entry and provide insights on Env conformation that are relevant for vaccine design.
A DIL-type miniature optical transceiver module using an InGaAsP half-transmittance photodiode for TCM optical access networks (1999)

A compact DIL-type miniature optical transceiver module has been developed without using a conventional 3 dB optical coupler. This transceiver is composed of a newly designed InGaAsP half-transmittance photodiode (HT-PD) and a 1.3-/spl mu/m multiquantum-well laser diode (MQW-LD). An HT-PD is used both as a photodetector and as a window for laser diode (LD) light. Fiber output power of 0 dBm at the drive current of 33.8 mA and responsivity of 0.58 A/W at the reverse-voltage of 2 V were obtained. The fundamental characteristics of the HT-PD are studied and discussed.
A Corning perspective on the future of technical glass in our evolving world (2022)

Abstract Glass is a material with a rich history and a bright future. Due to its outstanding properties and its versatility, it is a key material in many applications. In this paper, we present a variety of these applications in which glass is playing, and will continue to play, a significant role, including communication technologies, the semiconductor industry, advanced displays, mobile consumer electronics, healthcare, and automotive. Other critical considerations enabling continuous progress in glass science and engineering, such as improved modeling tools and characterization techniques, increased sustainability of the glass‐making process, and talent development, are also discussed.
GC-072, a Novel Therapeutic Candidate for Oral Treatment of Melioidosis and Infections Caused by Select Biothreat Pathogens (2019)

<i>Burkholderia pseudomallei</i> (<i>B. pseudomallei</i>), the etiological agent of melioidosis, is a Gram-negative bacterium with additional concern as a biothreat pathogen. The mortality rate from <i>B. pseudomallei</i> varies depending on the type of infection and extent of available health care, but in the case of septicemia left untreated it can range from 50 - 90%. Current therapy for melioidosis is biphasic, consisting of parenteral acute-phase treatment for two weeks or longer, followed by oral eradication-phase treatment lasting several months. An effective oral therapeutic for outpatient treatment of acute-phase melioidosis is needed. GC-072 is a potent, 4-oxoquinolizine antibiotic with selective inhibitory activity against bacterial topoisomerases. GC-072 has demonstrated <i>in vitro</i> potency against susceptible and drug-resistant strains of <i>B. pseudomallei</i> and is also active against <i>Burkholderia mallei</i>, <i>Bacillus anthracis</i>, <i>Yersinia pestis</i>, and <i>Francisella tularensis</i> GC-072 is bactericidal both extra- and intracellularly, with rapid killing noted within a few hours and reduced development of resistance compared to ceftazidime. GC-072, delivered intragastrically to mimic oral administration, promoted dose-dependent survival in mice using lethal inhalational models of <i>B. pseudomallei</i> infection following exposure to a 24 or 339 LD<sub>50</sub> challenge with <i>B. pseudomallei</i> strain 1026b. Overall, GC-072 appears to be a strong candidate for first-line, oral treatment of melioidosis.
Statin-Associated Muscular and Renal Adverse Events: Data Mining of the Public Version of the FDA Adverse Event Reporting System (2011)

Data mining of the FDA's adverse event reporting system, AERS, is useful for examining statin-associated muscular and renal adverse events. The data strongly suggest the necessity of well-organized clinical studies with respect to statin-associated adverse events.
Energy-efficient power amplifiers and linearization techniques for massive MIMO transmitters: a review (2020)

Highly efficient power amplifiers (PAs) and associated linearization techniques have been developed to accommodate the explosive growth in the data transmission rate and application of massive multiple input multiple output (mMIMO) systems. In this paper, energy-efficient integrated Doherty PA monolithic microwave integrated circuits (MMICs) and linearization techniques are reviewed for both the sub-6 GHz and millimeter-wave (mm-Wave) fifth-generation (5G) mMIMO systems; different semiconductor processes and architectures are compared and analyzed. Since the 5G protocols have not yet been finalized and PA specifications for mMIMO are still under consideration, it is worth investigating novel design methods to further improve their efficiency and linearity performance. Digital predistortion techniques need to evolve to be adapted in mMIMO systems, and some creative linearity enhancement techniques are needed to simultaneously improve the compensation accuracy and reduce the power consumption.