gebhart/patrepeval huggingface dataset:
Postprandial lysophospholipid suppresses hepatic fatty acid oxidation: the molecular link between group 1B phospholipase A 2 and diet‐induced obesity (2010)

Decrease in fat catabolic rate on consuming a high-fat diet contributes to diet-induced obesity. This study used group 1B phospholipase A(2) (Pla2g1b)-deficient mice, which are resistant to hyperglycemia, to test the hypothesis that Pla2g1b and its lipolytic product lysophospholipid suppress hepatic fat utilization and energy metabolism in promoting diet-induced obesity. The metabolic consequences of hypercaloric diet, including body weight gain, energy expenditure, and fatty acid oxidation, were compared between Pla2g1b(+/+) and Pla2g1b(-/-) mice. The Pla2g1b(-/-) mice displayed normal energy balance when fed chow, but were resistant to obesity when challenged with a hypercaloric diet. Obesity resistance in Pla2g1b(-/-) mice is due to their ability to maintain elevated energy expenditure and core body temperature when subjected to hypercaloric diet, which was not observed in Pla2g1b(+/+) mice. The Pla2g1b(-/-) mice also displayed increased postprandial hepatic fat utilization due to increased expression of peroxisome proliferator-activated receptor (PPAR)-alpha, PPAR-delta, PPAR-gamma, cd36/Fat, and Ucp2, which coincided with reduced postprandial plasma lysophospholipid levels. Lysophospholipids produced by Pla2g1b hydrolysis suppress hepatic fat utilization and down-regulate energy expenditure, thereby preventing metabolically beneficial adaptation to a high-fat diet exposure in promoting diet-induced obesity and type 2 diabetes.
Performance analysis of Givens rotation-integrated optical interdigitated-electrode cross-channel Bragg diffraction devices: extrinsic and inherent errors (1992)

The effects of extrinsic and inherent errors are analyzed for the integrated optical Givens rotation device. The extrinsic errors, caused by inaccurate voltage applied to the grating and inaccurate detection, are found to be important. The inherent errors caused by the propagation of these inaccuracies are detailed in algorithms for analog norm computation and in the QR algorithm for numerical linear algebra. A calibration procedure is developed to eliminate most of the errors.
Analysis of Inductance Gradient and Current Density Distribution Over Different Cross-section of Rails (2018)

In a rail gun system the armature accelerated due to the Lorentz force caused by the current which is diffused in to the rails. The entire system depends on the inductance gradient of the rail which is directly connected to the accelerating performance and efficiency of railgun. Hence, the exact analysis of inductance gradient is extremely significant for the railgun design. Since short duration of current pulse is applied to the rails determination of inductance gradient is very difficult. The inductance gradient varies with the geometric dimensions of the rails and armature. And it can be calculated with analytical method and numerical methods. In this paper inductance gradient of the rail has been computed and compared with the different rail cross-sectional models using Ansoft Maxwell Eddy current solver uses finite element technique to calculate the field distribution in a space. The current density, magnetic flux density, repulsive force acting on the rails also computed to analyze the performance of rail gun.
An approach to the analysis of spatially correlated multilevel functional data (2008)

Department of Statistics, Texas AM a method which is conceptually simple and straightforward to implement. Asecond novelty of our methodology is in using kernel smoothing estimation to estimate the spa-tial covariance function. The proposed procedure is illustrated with a simulation study and p27measurements data over relative cell position for a sample of rodents, in a colon carcinogenesisstudy.
The Dutch Resolution Variant of the Classical Resolution of Racemates by Formation of Diastereomeric Salts: Family Behaviour in Nucleation Inhibition (2005)

The resolution of racemates through their diastereomeric salts can be positively affected by the addition of small amounts of suitable nucleation inhibitors. This discovery is a logical extension of "Dutch Resolution", in which equimolar amounts of resolving agents that are members of the same family (i.e., structurally related) are used. We conducted a systematic search for nucleation inhibitors of the resolving agent 1-phenylethylamine. A wide range of amines that bear possible family resemblances to 1-phenylethylamine was investigated. It was found that (R)-1-phenylbutylamine is a good inhibitor of (R)-1-phenylethylamine. Results of turbidity measurements showed that, for the model case of mandelic acid resolution, the chief effect of this inhibitor was to widen the metastable zone for the more soluble diastereomer. This observation is in accordance with previous experience. Further scouting for possible family members revealed a wide variation in the effectiveness of inhibitors, dependent on their structure. By far the most effective inhibitors are bifunctional 1-phenylethylamine and/or 1-phenylbutylamine analogues. The effect of racemic inhibitors was found to approach that of enantiomerically pure inhibitors of the same absolute configuration of the 1-phenylethylamine used for resolution. The most effective inhibitors were tested for the resolution of a structural variety of racemates, and were shown to be broadly applicable.
On stability analysis of linear stochastic and time-varying deterministic systems (1992)

Article On stability analysis of linear stochastic and time-varying deterministic systems Share on Author: Cetin Cetinkaya View Profile Authors Info & Claims ISSAC '92: Papers from the international symposium on Symbolic and algebraic computationAugust 1992 Pages 278–283https://doi.org/10.1145/143242.143330Online:01 August 1992Publication History 1citation246DownloadsMetricsTotal Citations1Total Downloads246Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Vascular permeability during the early and late phases of ocular anaphylaxis. (1992)

The role of enhanced vascular permeability in a model of ocular anaphylaxis was investigated during both early- and late-phase reactions (EPR and LPR). Vascular permeability was assessed by measuring the extravascular retention of 125I-bovine serum albumin (125I-BSA) in ocular tissues. Ten groups of guinea pigs (n = 5-12 per group) were injected with dinitrophenylated (DNP) bovine gamma globulin emulsified in Freund's adjuvants and challenged after a 4-week interval by topical application of di-DNP-lysine to one eye and phosphate-buffered saline to the other eye. Thereafter, the eyes were examined and the animals were killed at different intervals after topical challenge. They were injected intravenously with 125I-BSA 0.5 hr before death. Retained radioactivity was measured separately in four tissues. The EPR (period between 0.5-1.5 hr after challenge) was characterized by enhanced retention of radioactivity in lids, conjunctiva, and orbital content. There was no significant retention of extravascular radioactivity in the globe and lacrimal gland. Thereafter (period between 2-3.5 hr after challenge), retained radioactivity was significantly diminished. The subsequent period, between 4.5-6.5 hr (LPR), was characterized by a smaller, although significant, increment of radioactivity retained in lids and conjunctiva but not in the other tissues examined. These findings indicate that enhanced microvascular permeability occurs during two phases in actively immunized guinea pigs challenged topically with di-DNP-lysine and that these phases correspond to the clinical signs that constitute the EPR and LPR of ocular anaphylaxis.
Isolation and characterization of influenza A viruses from avian species in Hong Kong. (1977)

Surveillance of apparently healthy ducks, chickens, and geese at a poultry dressing plant in Hong Kong yielded 51 haemagglutinating viruses 25 of which were influenza A viruses. Of these, 24 were subtyped into 13 combinations based on haemagglutinin and neuraminidase surface antigens. Of the 13 different influenza A viruses isolated, 7 possessed combinations of haemagglutinin and neuraminidase subunits that have not been reported previously-i.e., Hav2N1, Hav2Nav5, Hav4N2, Hav7N2, Hav7Nav1, Hav7Nav3, and Hav7Nav6. Four of the isolates were non-avid: they were not neutralized by antisera to any of the reference subtypes of influenza A viruses, yet antisera to each isolate inhibited both that virus and a known reference strain. The large number of combinations of haemagglutinin and neuraminidase and the isolation of two different influenza A viruses from one duck suggests that recombination may be occurring in nature.
New Carbon Economy Corporate Roundtable: Carbon Conversion to Valuable Products (2019)

Lawrence Livermore National Laboratory and Carbon180 hosted a workshop entitled “The New Carbon Economy Corporate Roundtable: Carbon Conversion to Valuable Products." The primary intent of the workshop was to initiate a conversation about opportunities to convert carbon in the air into valuable products.
Privacy enforcement through policy extension (2016)

Successful coalition operations require contributions from the coalition partners which might have hidden goals and desiderata in addition to the shared coalition goals. Therefore, there is an inevitable risk-utility trade-off for information producers due to the need-to-know vs. need-to-hide tension, which must take into account the trustworthiness of the other coalition partners. A balance is often achieved by deliberate obfuscation of the shared information. In this paper, we show how to integrate obfuscation capabilities within the current OASIS standard for access control policies, namely XACML.
InP Nanowire Diodes on Quartz Substrates (2008)

We demonstrate, for the first time, a unique p-i-n diode structure composed of ensembles of unintentionally doped InP nanowires bridging p-type and n-type hydrogenated microcrystalline silicon (muc-Si:H) layers on a quartz substrate. Selective area growth was used to restrict nanowires to the perimeter of a circular hole etched into vertically stacked p+ muc-Si:H/SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /n+ muc-Si:H thin films. DC electrical measurements confirm diode current-voltage characteristics with 25 nA reverse leakage current and an ideality factor of 3.9. Our demonstration suggests that active devices incorporating III-V compound semiconductor nanowires can be integrated onto low cost non- single crystal material platforms.
Finite RF Pulse Effects on Quantitative Magnetization Transfer Imaging Using Balanced SSFP (2010)

It has recently been shown that the effect of finite RF pulses can lead to considerable balanced SSFP (bSSFP) signal modulations. As bSSFP-based quantitative magnetization transfer imaging (qMTI) uses RF pulse modifications, a correction for these effects has to be included. In this work, a modification to the two-pool bSSFP equation is presented and effects on the parameter maps are assessed in human brain. This finite RF pulse correction improves the fitting quality considerably and reduces the values of the bound pool fraction F, the exchange rate kf and the transverse relaxation time of the free pool T2,f by about 10%.
Bromodomain inhibition shows antitumoral activity in mice and human luminal breast cancer (2017)

BET bromodomain inhibitors, which have an antitumoral effect against various solid cancer tumor types, have not been studied in detail in luminal breast cancer, despite the prevalence of this subtype of mammary malignancy. Here we demonstrate that the BET bromodomain inhibitor JQ1 exerts growth-inhibitory activity in human luminal breast cancer cell lines associated with a depletion of the C-MYC oncogene, but does not alter the expression levels of the BRD4 bromodomain protein. Interestingly, expression microarray analyses indicate that, upon JQ1 administration, the antitumoral phenotype also involves downregulation of relevant breast cancer oncogenes such as the Breast Carcinoma-Amplified Sequence 1 (BCAS1) and the PDZ Domain-Containing 1 (PDZK1). We have also applied these <i>in vitro</i> findings in an <i>in vivo</i> model by studying a transgenic mouse model representing the luminal B subtype of breast cancer, the MMTV-PyMT, in which the mouse mammary tumor virus promoter is used to drive the expression of the polyoma virus middle T-antigen to the mammary gland. We have observed that the use of the BET bromodomain inhibitor for the treatment of established breast neoplasms developed in the MMTV-PyMT model shows antitumor potential. Most importantly, if JQ1 is given before the expected time of tumor detection in the MMTV-PyMT mice, it retards the onset of the disease and increases the survival of these animals. Thus, our findings indicate that the use of bromodomain inhibitors is of great potential in the treatment of luminal breast cancer and merits further investigation.
HIV-1 GP140 immunogens comprising modified NHR1 regions that stabilize pre-fusion conformations (2023)

The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
High-resolution solid-state proton MASS NMR of superabsorbing polymeric gels (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh-resolution solid-state proton MASS NMR of superabsorbing polymeric gelsS. Ganapathy, M. V. Badiger, P. R. Rajamohanan, and R. A. MashelkarCite this: Macromolecules 1989, 22, 4, 2023–2025Publication Date (Print):April 1, 1989Publication History Published online1 May 2002Published inissue 1 April 1989https://pubs.acs.org/doi/10.1021/ma00194a089https://doi.org/10.1021/ma00194a089research-articleACS PublicationsRequest reuse permissionsArticle Views57Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Traction Control for Ride-by-Wire Sport Motorcycles: A Second-Order Sliding Mode Approach (2009)

This paper addresses the analysis and design of a safety-oriented traction control system for ride-by-wire sport motorcycles based on the second-order sliding mode methodology. The controller design is based on a nonlinear dynamical model of the rear wheel slip, and the modeling phase is validated against experimental data measured on an instrumented vehicle. To comply with practical applicability constraints, the position of the electronic throttle body is used as control variable and the effect of the actuator dynamics is thoroughly analyzed. After a discussion on the interplay between the controller parameters and the tracking performance, the final design effectiveness is assessed via mechanical simulation corporation BikeSim, a full-fledged commercial multibody motorcycle model.
High-Efficiency Impedance Control Network Resonant DC–DC Converter With Optimized Startup Control (2017)

This paper presents an improved efficiency impedance control network (ICN) resonant dc-dc converter that maintains zero-voltage switching (ZVS) and near-zero-current switching (ZCS) across wide ranges in input and output voltages and output power. The improvement in efficiency in this burst mode operated converter is achieved through an optimized startup control that minimizes its startup transient and helps the converter maintain ZVS and near-ZCS operation, even during the startup for each burst cycle. This optimization of startup is made possible by a new accurate time domain model for the ICN converter waveforms that helps reduce the number of non-ZVS transitions by 75%. A prototype 200 W, 500 kHz ICN resonant converter designed to operate over an input voltage range of 25-40 V and output voltage range of 250-400 V is built and tested. The prototype ICN converter achieves a peak efficiency of 97.2% and maintains greater than 96.2% full power efficiency at 250 V output voltage across the nearly 2:1 input voltage range, and maintains full power efficiency above 94.6% across its full input and output voltage range. The converter also maintains efficiency above 93.6% over a 10:1 output power range across its full input and output voltage range.
Clinicopathologic features and outcomes of patients with lung adenocarcinomas harboring BRAF mutations in the Lung Cancer Mutation Consortium (2014)

BRAF mutations occurred in 2.2% of advanced-stage lung adenocarcinomas, were most commonly V600E, and were associated with distinct clinicopathologic features in comparison with other genomic subtypes and with a high mutation rate in more than 1 gene. These findings underscore the importance of comprehensive genomic profiling in assessing patients with advanced lung adenocarcinomas.
Rotational spectra and structures of small clusters containing the HCN dimer: (HCN)2–Ar, a T-shaped trimer (1988)

Microwave rotational spectra have been observed for the four 14N/15N isotopic species of an (HCN)2–Ar trimer with the pulsed nozzle Fourier transform method using the Flygare Mark II spectrometer. Thirteen J→J′ asymmetric top transitions were measured in the 2.5 to 10 GHz region for the parent 14N,14N trimer and nine for each of the other three species. The 14N nuclear quadrupole hyperfine structure was analyzed for the transitions and the interaction constants and line centers determined. The line centers were fitted to obtain ground vibronic state rotational and quartic centrifugal distortion constants. For the 14N/14N trimer these are (in MHz) for A″, B″, and C″: 2013.5993(10), 1759.2756(3), 932.3709(2); and for τ1, τ2, τaaaa, τbbbb, and τcccc: −0.3017(1), −0.0660(1), −0.1700(9), −0.013 71(1), and −0.0088(1). The inertial defect is 3.7881 amu Å2. The zero-point vibrationally averaged geometry is planar and T shaped with the structure of the linear HCN dimer remarkably unperturbed by presence of the Ar atom. The substitution N⋅⋅⋅N distance in the cluster is 4.453 Å compared with 4.461 Å in the free dimer. The argon is attracted by the π electrons of the two –C≡N groups, being equidistant from them. The Ar⋅⋅⋅N(1) and Ar⋅⋅⋅N(2) distances are 3.671 and 4.316 Å, respectively.
Emergence of ferromagnetism due to charge transfer in compressed ilmenite powder using super-high-energy ball milling (2020)

Ilmenite, FeTiO<sub>3</sub>, is a common mineral in nature, existing as an accessory phase in the most basic igneous and metamorphic rocks, for example, it is derived from the upper mantle. Therefore, an understanding of the high-pressure physics of FeTiO<sub>3</sub> is of fundamental importance in the study of rock magnetization. Here, we provide experimental evidence of lattice compression of FeTiO<sub>3</sub> powder using super-high-energy ball milling, enabling the very high collision energy of 420 times gravitational acceleration. A sample obtained as an ilmenite- hematite 0.5FeTiO<sub>3</sub>·0.5Fe<sub>2</sub>O<sub>3</sub> solid solution showed a decrease in molar volume of approximately 1.8%. Consequently, the oxidation state in FeTiO<sub>3</sub> powder was changed into almost Fe<sup>3+</sup>Ti<sup>3+</sup>, corresponding to 87% Fe<sup>3+</sup> of the total Fe for FeTiO<sub>3</sub>, resulting in the emergence of ferromagnetism. This new ferromagnetic behaviour is of crucial importance in the study of rock magnetization which is used to interpret historical fluctuations in geomagnetism. In addition, the super-high-energy ball mill can be used to control a range of charge and spin states in transition metal oxides with high pressure.
An optical adaptive resonance neural network utilizing phase conjugation (1992)

An adaptive resonance (ART) device has been conceived that is fully optical in the input-output processing path. It is based on holographic information processing in a phase-conjugating crystal. This sets up an associative pattern retrieval in a resonating loop utilizing angle-multiplexed reference beams for pattern classification. A reset mechanism is used to reject any given beam, allowing an ART search strategy. The design is similar to an existing nonlearning optical associative memory, but it does allow learning and makes use of information the other device discards. This device is expected to offer higher information storage density than alternative ART implementations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood (2021)

Leukotrienes are pro-inflammatory lipid mediators generated by 5-lipoxygenase aided by the 5-lipoxygenase-activating protein (FLAP). BRP-201, a novel benzimidazole-based FLAP antagonist, inhibits leukotriene biosynthesis in isolated leukocytes. However, like other FLAP antagonists, BRP-201 fails to effectively suppress leukotriene formation in blood, which limits its therapeutic value. Here, we describe the encapsulation of BRP-201 into poly(lactide-co-glycolide) (PLGA) and ethoxy acetalated dextran (Ace-DEX) nanoparticles (NPs), aiming to overcome these detrimental pharmacokinetic limitations and to enhance the bioactivity of BRP-201. NPs loaded with BRP-201 were produced via nanoprecipitation and the physicochemical properties of the NPs were analyzed in-depth using dynamic light scattering (size, dispersity, degradation), electrophoretic light scattering (effective charge), NP tracking analysis (size, dispersity), scanning electron microscopy (size and morphology), UV-VIS spectroscopy (drug loading), an analytical ultracentrifuge (drug release, degradation kinetics), and Raman spectroscopy (chemical attributes). Biological assays were performed to study cytotoxicity, cellular uptake, and efficiency of BRP-201-loaded NPs versus free BRP-201 to suppress leukotriene formation in primary human leukocytes and whole blood. Both PLGA- and Ace-DEX-based NPs were significantly more efficient to inhibit leukotriene formation in neutrophils versus free drug. Whole blood experiments revealed that encapsulation of BRP-201 into Ace-DEX NPs strongly increases its potency, especially upon pro-longed (≥ 5 h) incubations and upon lipopolysaccharide-challenge of blood. Finally, intravenous injection of BRP-201-loaded NPs significantly suppressed leukotriene levels in blood of mice in vivo. These results reveal the feasibility of our pharmacological approach using a novel FLAP antagonist encapsulated into Ace-DEX-based NPs with improved efficiency in blood to suppress leukotriene biosynthesis.