gebhart/patrepeval huggingface dataset:
Heat capacity and vibrational spectra of monolayer films adsorbed in nanotubes (1998)

Carbon or boron nitride nanotubes can adsorb condensed-phase monolayer films on their inner surfaces. Examples include inert gas or hydrogen films, which form at low temperatures in nanotubes with radius $&gt;~5 \mathrm{\AA{}}.$ We study the phonon modes and thermodynamic properties of such films. Azimuthal quantization yields quasi-one-dimensional behavior at low temperature, manifested by a heat capacity linear in T, with quasi-two-dimensional behavior at higher temperature; the crossover between these regimes has a universal form, depending only on the ratio of the film radius to the thermal phonon wavelength. The film radius and mean sound speed can be extracted from the temperature dependence of the heat capacity.
40G Field Trial with 0.8 bits/s/Hz Spectral Efficiency over 6,550 km of Installed Undersea Cable (2011)

We successfully demonstrated 64×40Gb/s transmission over 6,550km installed undersea cable using SubCom’s 40G transceivers. More than 3.3dB FEC margin for all measured channels was achieved matching our simulator predictions.
Novel dental adhesive containing antibacterial agents and calcium phosphate nanoparticles (2012)

Secondary caries remains the main reason for dental restoration failure. Replacement of failed restorations accounts for 50%-70% of all restorations performed. Antibacterial adhesives could inhibit biofilm acids at tooth-restoration margins, and calcium phosphate (CaP) ions could remineralize tooth lesions. The objectives of this study were to: (1) incorporate nanoparticles of silver (NAg), quaternary ammonium dimethacrylate (QADM), and nanoparticles of amorphous calcium phosphate (NACP) into bonding agent; and (2) investigate their effects on dentin bonding and microcosm biofilms. An experimental primer was made with pyromellitic glycerol dimethacrylate (PMGDM) and 2-hydroxyethyl methacrylate (HEMA). An adhesive was made with bisphenol-A-glycerolate dimethacrylate (BisGMA) and triethylene glycol dimethacrylate (TEGDMA). NAg was incorporated into primer at 0.1 wt %. The adhesive contained 0.1% NAg and 10% QADM, and 0%-40% NACP. Incorporating NAg into primer and NAg-QADM-NACP into adhesive did not adversely affect dentin bond strength (p > 0.1). Scanning electron microscopy showed numerous resin tags, and transmission electron microscopy revealed NAg and NACP in dentinal tubules. Viability of human saliva microcosm biofilms on primer/adhesive/composite disks was substantially reduced via NAg and QADM. Metabolic activity, lactic acid, and colony-forming units of biofilms were much lower on the new bonding agents than control (p < 0.05). In conclusion, novel dental bonding agents containing NAg, QADM, and NACP were developed with the potential to kill residual bacteria in the tooth cavity and inhibit the invading bacteria along tooth-restoration margins, with NACP to remineralize tooth lesions. The novel method of combining antibacterial agents (NAg and QADM) with remineralizing agent (NACP) may have wide applicability to other adhesives for caries inhibition.
Programmable Liquid Crystal Defect Arrays via Electric Field Modulation for Mechanically Functional Liquid Crystal Networks (2021)

The arrangement of mesogenic units determines mechanical response of the liquid crystal polymer network (LCN) film to heat. Here, we show an interesting approach to programming three-dimensional patterns of the LCN films with periodic topological defects generated by applying an electric field. The mechanical properties of three representative patterned LCN films were investigated in terms of the arrangement of mesogenic units through tensile testing. Remarkably, it was determined that LCN films showed enhanced toughness and ductility as defects increased in a given area, which is related to the elastic modulus mismatch that mitigates crack propagation. Our platform can also be used to modulate the frictional force of the patterned LCN films by varying the temperature, which can provide insight into the multiplex mechanical properties of LCN films.
Microphase Separation of Segmented Poly(urethane urea) Block Copolymers (2000)

Two series of well-defined poly(urethane urea) multiblock copolymers were synthesized to investigate the phase-separated morphology of this family of materials. Series I copolymers were synthesized from 2000 g/mol poly(tetramethylene oxide) [PTMO], 4,4‘-methylene di(p-phenyl isocyanate) [MDI], and ethylenediamine (EDA), with hard segment contents ranging from 14 to 47 wt %. Series II copolymers (all with hard segment concentrations of 22 wt %) were prepared from the same PTMO and MDI and a diamine mixture of EDA and 1,4-diaminocyclohexane. The microdomain morphology was characterized using small-angle X-ray scattering, and the scattering data were analyzed using the approach of Bonart and Müller. The series I and II copolymers were found to have relatively low overall degrees of phase separation [ranging from ∼20% at the lowest hard segment contents to greater than 40%], contrary to the common notion that these copolymers are well phase separated materials. The introduction of the second diamine results in reduced phase separation, presumably as a consequence of disruption of hard segment hydrogen bonding.
User-centric Design of Mobile & Remote Health Care and Safety Services and Supporting Technologies for China and Finland (2009)

UBI-SERV project investigates services and technology for ubiquitous computing (e.g. services applying networked, embedded computers) in welfare technology and services. User-centric design approach is applied to pinpoint the cases that fulfill research border conditions, focusing on senior citizens and selected public safety services, both in Chinese and Finnish service technology market, so that academic objectives, i.e. user-centric design goals and true business cases, can be simultaneously investigated. Also, we strive to efficient utilization of usability research methodology, general resources and scientific expertise of our research consortium. The project has research teams at Helsinki University of Technology (TKK) and Peking University (PKU). Keywords—User-centric design, remote health care, public safety, wireless networks, mobile phones, sensors
Guideline for Developing High-density Recording Media Based on Magnetic Cluster Analysis (2010)

We examined the relationship between media cluster size distribution and signal quality to obtain a guideline for developing high-density recording media. Both spin-stand measurements and micromagnetics simulations were used. The cluster size distribution and SNR of various recording media were evaluated, and the relationship between the two was analyzed using multiple regression analysis. The results demonstrate that the media SNR could be quantitatively estimated from the cluster size distribution (both average sizes and size deviations). Although reducing either the average size or the size deviation was effective in terms of improving theSNR, the impact of the average was much larger. On the other hand, we also found that the effect of size deviation increased for the smaller average-sized media. We concluded that providing the guidelines for each individual developing medium is a key step and that the proposed analysis method is therefore effective.
Author response: Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation (2016)

Structures called mitochondria act like the batteries of cells, and use several different metabolic processes to release energy. For example, neurons rely on a metabolic process called oxidative phosphorylation, while neural progenitor cells (which develop, or differentiate, into neurons) use a process called aerobic glycolysis instead. Little is known about why neurons prefer to use oxidative phosphorylation to provide them with energy, and it is also not clear why problems that affect this process are often seen in neurological disorders and neurodegenerative diseases. Zheng, Boyer et al. have now used human neural progenitor cells to explore the metabolic changes that occur as these cells develop into neurons. It appears that the loss of two metabolic enzymes, called hexokinase and lactate dehydrogenase, marks the transition from aerobic glycolysis to oxidative phosphorylation. In addition, the instructions to produce an enzyme called pyruvate kinase are altered or “alternatively spliced” when progenitor cells differentiate, which in turn changes the structure of the enzyme. The levels of the proteins that activate and regulate the production of these three metabolic enzymes also decrease dramatically during this transition. Further experiments showed that neurons that produce hexokinase and lactate dehydrogenase while they differentiate die, which means that neurons must shut off aerobic glycolysis in order to survive. The amounts of two proteins that regulate metabolism (called PGC-1α and ERRγ) increase significantly when a neuron differentiates. This sustains a constant level of activity for several metabolic and mitochondrial genes as neural progenitor cells differentiate to form neurons. Zheng, Boyer et al. also found that neurons build more mitochondria as they grow; this suggests that an unknown mechanism exists that links the creation of mitochondria to the size of the neuron. Zheng, Boyer et al. have mainly focused on how much of each metabolic enzyme is produced inside cells, but these levels may not completely reflect the actual level of enzyme activity. The next steps are therefore to investigate whether any other processes or modifications play a part in regulating the enzymes. Further investigation is also needed to determine the effects of changes in mitochondrial structure that occur as a neuron develops from a neural progenitor cell.
Overcoming catalyst deactivation during the continuous conversion of sugars to chemicals: maximising the performance of Sn-Beta with a little drop of water (2017)

The stability of Sn-beta for the continuous upgrading of sugars is enhanced dramatically by small amounts of water.
Supplementary Figure 3 from Constitutive Activation of Signal Transducers and Activators of Transcription Predicts Vorinostat Resistance in Cutaneous T-Cell Lymphoma (2023)

Supplementary Figure 3 from Constitutive Activation of Signal Transducers and Activators of Transcription Predicts Vorinostat Resistance in Cutaneous T-Cell Lymphoma
Dynamic depolarization in plasmonic metal nanoparticles (2016)

At very low photon energies most metals have a very large and negative dielectric function. For the response of a metal nanoparticle to an external field in this limit, this means that the particular choice of metal does not matter and the localized surface plasmon energy mainly depends on the shape and size of the particle. Here, we present a theoretical framework to describe this situation and unearth the interplay between the depolarization factor of the problem at hand and the dielectric function of the particle. Available experimental results compare favorably with our theoretical framework.
Assessment of imaging parameters correlated with the effects of cryopreservation on embryo development (2014)

Embryo cryopreservation is an increasingly common technique that allows patients to undergo multiple cycles of <i>in vitro</i> fertilization (IVF) without being subjected to repeated ovarian stimulation and oocyte retrieval. There are two types of cryopreservation commonly used in IVF clinics today: slow freezing and vitrification. Because vitrification has been shown to result in higher rates of embryo survival post-thaw compared to slow freezing, it is rapidly gaining popularity in clinics worldwide. However, several studies have shown that vitrification can still cause damage to embryos in the form of DNA fragmentation, altered mitochondrial distribution and changes in transcriptional activity, all of which are impossible to assess noninvasively. In this paper we demonstrate a new method of quantitatively and noninvasively assessing changes in embryo appearance due to vitrification. Using full-field optical coherence tomography (FF-OCT), we show that vitrification causes striking changes in the appearance of the cytoplasm that are not visible under conventional brightfield microscopy. Using an automated algorithm that extracts parameters to describe these changes, we show that these parameters can also predict viability in embryos that have undergone vitrification. An automated, noninvasive assessment of embryo viability after vitrification and thawing could have significant clinical impact: allowing clinicians to more accurately choose the most viable embryos to transfer back to patients could reduce the average number of IVF cycles that patients must undergo to achieve pregnancy.
Efficient Length Doubling From Tweakable Block Ciphers (2017)

We present a length doubler, LDT, that turns an n-bit tweakable block cipher into an efficient and secure cipher that can encrypt any bit string of length [n..2n − 1]. The LDT mode is simple, uses only two cryptographic primitive calls (while prior work needs at least four), and is a strong length-preserving pseudorandom permutation if the underlying tweakable block ciphers are strong tweakable pseudorandom permutations. We demonstrate that LDT can be used to neatly turn an authenticated encryption scheme for integral data into a mode for arbitrary-length data.
A metric for evaluation of the performance of saliency-tracking self-sensing control of PM motor (2013)

This paper presents a study on the performance of saliency-tracking self-sensing method for a permanent-magnet synchronous motor. It is shown that the high speed limit is a function of modulation harmonics and the extraction of the rotor information contained in the HF currents envelope as rotor speed increases. These effects degrade the rotor position signals and consequently the estimated rotor speed and the reference current. A method based on the maximum harmonic content in the reference current is detailed. The method determines the selection of observer bandwidth and the dynamic stiffness of the drive system. A complete set of simulation results is presented and validate the analysis proposed.
Reverse geroscience: how does exposure to early diseases accelerate the age‐related decline in health? (2016)

Aging is the major risk factor for both the development of chronic diseases and loss of functional capacity. Geroscience provides links among the biology of aging, the biology of disease, and the physiology of frailty, three fields where enormous progress has been made in the last few decades. While, previously, the focus was on the role of aging in susceptibility to disease and disability, the other side of this relationship, which is the contribution of disease to aging, has been less explored at the molecular/cellular level. Indeed, the role of childhood or early adulthood exposure to chronic disease and/or treatment on accelerating aging phenotypes is well known in epidemiology, but the biological basis is poorly understood. A recent summit co-organized by the National Institutes of Health GeroScience Interest Group and the New York Academy of Sciences explored these relationships, using three chronic diseases as examples: cancer, HIV/AIDS, and diabetes. The epidemiological literature clearly indicates that early exposure to any of these diseases and/or their treatments results in an acceleration of the appearance of aging phenotypes, including loss of functional capacity and accelerated appearance of clinical symptoms of aging-related diseases not obviously related to the earlier event. The discussions at the summit focused on the molecular and cellular relationships between each of these diseases and the recently defined molecular and cellular pillars of aging. Two major conclusions from the meeting include the desire to refine an operational definition of aging and to concomitantly develop biomarkers of aging, in order to move from chronological to physiological age. The discussion also opened a dialogue on the possibility of improving late-life outcomes in patients affected by chronic disease by including age-delaying modalities along with the standard care for the disease in question.
HiSIM: a drift-diffusion-based advanced MOSFET model for circuit simulation with easy parameter extraction (2002)

We present here the MOSFET model HiSIM (Hiroshima University Starc IGFET model). As HiSIM employs the drift-diffusion approximation and preserves correct modeling of the surface potential in the channel, it is not only accurate, but additionally, model parameter number is small, parameter interdependence is removed, and parameter extraction becomes easy. Measured current-voltage characteristics of advanced MOSFETs are thus reproduced with only 19 model parameters.
Light‐Activated Gene Editing with a Photocaged Zinc‐Finger Nuclease (2011)

Durch Mutagenese lässt sich eine Zinkfinger-Nuclease erhalten, in der sich ein nichtnatürliches photoaktivierbares Tyrosin an einer DNA-Protein-Grenzfläche befindet. Weil das photoaktivierbare Enzym so lange inaktiv ist, bis es mit UV-Licht bestrahlt wird, ist ein sequenzspezifisches Editieren von Genen in Säugerzellen möglich (siehe Bild). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist (2010)

Incorporation of polar functionality into a series of highly potent calcitonin gene-related peptide (CGRP) receptor antagonists was explored in an effort to improve pharmacokinetics. This strategy identified piperazinone analogues that possessed improved solubility at acidic pH and increased oral bioavailability in monkeys. Further optimization led to the discovery of the clinical candidate 2-[(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]-N-[(2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl]acetamide (MK-3207) (4), the most potent orally active CGRP receptor antagonist described to date.
Induction Chemotherapy for Primarily Unresectable Locally Advanced Pancreatic Adenocarcinoma—Who Will Benefit from a Secondary Resection? (2021)

<i>Background and Objectives:</i> An increasing number of patients (pts) with locally advanced pancreatic cancer (LAPC) are treated with an intensive neoadjuvant therapy to obtain a secondary curative resection. Only a certain number of patients benefit from this intention. The aim of this investigation was to identify prognostic factors which may predict a benefit for secondary resection. <i>Materials and Methods:</i> Survival time and clinicopathological data of pts with pancreatic cancer were prospective and consecutively collected in our Comprehensive Cancer Center Database. For this investigation, we screened for pts with primarily unresectable pancreatic cancer who underwent a secondary resection after receiving induction therapy in the time between March 2017 and May 2019. <i>Results:</i> 40 pts had a sufficient database to carry out a reliable analysis. The carbohydrate-antigen 19-9 (CA 19-9) level of the pts treated with induction therapy decreased by 44.7% from 4358.3 U/mL to 138.5 U/mL (<i>p</i> = 0.001). The local cancer extension was significantly reduced (<i>p</i> < 0.001), and the Eastern Cooperative Oncology Group (ECOG) performance status was lowered (<i>p</i> = 0.03). The median overall survival (mOS) was 20 months (95% CI: 17.2-22.9). Pts who showed a normal CA 19-9 level (<37 U/mL) at diagnosis and after neoadjuvant therapy or had a Body Mass Index (BMI) below 25 kg/m<sup>2</sup> after chemotherapy had a significant prolonged overall survival (29 vs. 19 months, <i>p</i> = 0.02; 26 vs. 18 months, <i>p</i> = 0.04; 15 vs. 24 months, <i>p</i> = 0.01). Pts who still presented elevated CA 19-9 levels >400 U/mL after induction therapy did not profit from a secondary resection (24 vs. 7 months, <i>p</i> < 0.001). Nodal negativity as well as the performance of an adjuvant therapy lead to better mOS (25 vs. 15 months, <i>p</i> = 0.003; 10 vs. 25 months, <i>p</i> < 0.001). <i>Conclusion:</i> The pts in our investigation had different benefits from the multimodal treatment. We identified the CA 19-9 level at time of diagnosis and after neoadjuvant therapy as well as the preoperative BMI as predictive factors for overall survival. Furthermore, diagnostics of presurgical nodal status should gain more importance as nodal negativity is associated with better outcome.
Modulare Produktstrukturierung (2018)

No AccessHandbuch KonstruktionJun 2018Modulare ProduktstrukturierungDieter Krause, Johanna Spallek, Christoph Blees, Thomas KippDieter KrauseSearch for more papers by this author, Johanna SpallekSearch for more papers by this author, Christoph BleesSearch for more papers by this author, Thomas KippSearch for more papers by this authorhttps://doi.org/10.3139/9783446456198.025SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2018Pages: 717-741Print ISBN: 978-3-446-45224-4eISBN: 978-3-446-45619-8 Copyright & Permissions© 2018 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
An shRNA-Based Screen of Splicing Regulators Identifies SFRS3 as a Negative Regulator of IL-1β Secretion (2011)

The generation of diversity and plasticity of transcriptional programs are key components of effective vertebrate immune responses. The role of Alternative Splicing has been recognized, but it is underappreciated and poorly understood as a critical mechanism for the regulation and fine-tuning of physiological immune responses. Here we report the generation of loss-of-function phenotypes for a large collection of genes known or predicted to be involved in the splicing reaction and the identification of 19 novel regulators of IL-1β secretion in response to E. coli challenge of THP-1 cells. Twelve of these genes are required for IL-1β secretion, while seven are negative regulators of this process. Silencing of SFRS3 increased IL-1β secretion due to elevation of IL-1β and caspase-1 mRNA in addition to active caspase-1 levels. This study points to the relevance of splicing in the regulation of auto-inflammatory diseases.
ChemInform Abstract: Pentafulvenes by Aminomethinylation of Cyclopentadiene. (1986)

Abstract Durch die aufgeführte Dreikomponentenreaktion gelingt es, die Pentafulvene (IV) zu synthetisieren.
Thermal annealing study of the mid-infrared aluminum nitride on insulator (AlNOI) photonics platform (2019)

Aluminum nitride on insulator (AlNOI) photonics platform has great potential for mid-infrared applications thanks to the large transparency window, piezoelectric property, and second-order nonlinearity of AlN. However, the deployment of AlNOI platform might be hindered by the high propagation loss. We perform thermal annealing study and demonstrate significant loss improvement in the mid-infrared AlNOI photonics platform. After thermal annealing at 400°C for 2 hours in ambient gas environment, the propagation loss is reduced by half. Bend loss and taper coupling loss are also investigated. The performance of multimode interferometer, directional coupler, and add/drop filter are improved in terms of insertion loss, quality factor, and extinction ratio. Fourier-transform infrared spectroscopy, Raman spectroscopy, and X-ray diffraction spectroscopy suggest the loss improvement is mainly attributed to the reduction of extinction coefficient in the silicon dioxide cladding. Apart from loss improvement, appropriate thermal annealing also helps in reducing thin film stress.