gebhart/patrepeval huggingface dataset:
Conversion of differentiation inducer resistance to differentiation inducer sensitivity in erythroleukemia cells. (1990)

Hexamethylene bisacetamide (HMBA) is a potent inducer of differentiation of murine erythroleukemia cells (MELC). Commitment, the irreversible initiation of the program of terminal-cell differentiation, is first detected in HMBA-sensitive DS19-SC9 MELC in culture after 10 to 12 h of exposure to HMBA. Vincristine (VC)-resistant MELC derived from the DS19-SC9 MELC line display increased sensitivity to HMBA and become committed with little or no latent period. In the present study, we showed that the MELC line R1, which is resistant to HMBA-mediated differentiation, became sensitive to inducer if selected for a low level of VC resistance (less than 10 ng of VC per ml). Four independently derived VC-resistant cell lines from HMBA-resistant R1 cells, designated R1[VCR]a to R1[VCR]d, acquired sensitivity to HMBA and the accelerated kinetics of commitment that are characteristic of VC-resistant MELC derived from the parental DS19-SC9 cells. The calcium channel blocker verapamil suppresses the VC resistance of R1[VCR] cells but does not alter the accelerated response to HMBA. In R1[VCR] cells there was no detectable increase in the level of the 140-kilodalton P-glycoprotein. Transient inhibition of protein synthesis during the latent period delays inducer-mediated commitment of VC-sensitive DS19-SC9 MELC but does not alter the accelerated commitment kinetics of R1[VCR]a cells. Previously, we have reported evidence that protein kinase C beta (PKC beta) plays a role in HMBA-induced MELC differentiation and that compared with DS19-SC9 cells, R1 cells have a relatively low level and R1[VCR]a cells have a high level of PKC beta. These findings suggest that (i) acquisition of VC resistance overcomes the block acquired by R1 cells to HMBA-mediated differentiation; (ii) the accelerated kinetics of HMBA-induced commitment of VC-resistant MELC is not dependent on the verapamil-sensitive transport channel that is responsible, at least in part, for resistance to VC; (iii) in VC-resistant MELC, there is constitutive expression or accumulation of a protein required for HMBA-induced differentiation; and (iv) an elevated level of PKC beta activity may play a role in the altered response of R1[VCR] and other VC-resistant MELC to HMBA.
Welcome to Professor Hsin-Yi Lai, the Newest Associate Editor for ACS Chemical Neuroscience (2020)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTWelcome to Professor Hsin-Yi Lai, the Newest Associate Editor for ACS Chemical NeuroscienceCraig W. LindsleyCraig W. LindsleyMore by Craig W. Lindsleyhttp://orcid.org/0000-0003-0168-1445Cite this: ACS Chem. Neurosci. 2020, 11, 11, 1519Publication Date (Web):June 3, 2020Publication History Published online3 June 2020Published inissue 3 June 2020https://pubs.acs.org/doi/10.1021/acschemneuro.0c00266https://doi.org/10.1021/acschemneuro.0c00266editorialACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views781Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (464 KB) Get e-AlertscloseSUBJECTS:Central nervous system,Chemical neuroscience,Imaging,Neuroscience,Ultrasound Get e-Alerts
Remote Training for Medical Staff in Low-Resource Environments Using Augmented Reality (2022)

This work aims to leverage medical augmented reality (AR) technology to counter the shortage of medical experts in low-resource environments. We present a complete and cross-platform proof-of-concept AR system that enables remote users to teach and train medical procedures without expensive medical equipment or external sensors. By seeing the 3D viewpoint and head movements of the teacher, the student can follow the teacher’s actions on the real patient. Alternatively, it is possible to stream the 3D view of the patient from the student to the teacher, allowing the teacher to guide the student during the remote session. A pilot study of our system shows that it is easy to transfer detailed instructions through this remote teaching system and that the interface is easily accessible and intuitive for users. We provide a performant pipeline that synchronizes, compresses, and streams sensor data through parallel efficiency.
<title>Classified wavelet transform coding of images using vector quantization</title> (1994)

The discrete wavelet transform (DWT) has recently emerged as a powerful technique for image compression in conjunction with a variety of quantization schemes. In this paper, a new image coding scheme--classified wavelet transform/vector quantization (DWT/CVQ)--is proposed to efficiently exploit correlation among different DWT layers aiming to improve its performance. In this scheme, DWT coefficients are rearranged to form the small blocks, which are composed of the corresponding coefficients from all the subbands. The block matrices are classified into four classes depending on the directional activities, i.e., energy distribution along each direction. These are further divided adaptively into subvectors depending on the DWT coefficient statistics as this allows efficient distribution of bits. The subvectors are then vector quantized. Simulation results show that under this technique the reconstruction images preserve the detail and structure in a subjective sense compared to other approaches at a bit rate of 0.3 bit/pel.
Towards Understanding the Evolution of Wars in Virtual and Real Worlds (2009)

Emerging massively multiplayer online real time strategy games require complex game server architecture to make the transmission of the state information of a huge number of units generated by a lot of players feasible. This architecture design is supported by network traffic simulations based on the accurate characterization of player behavior. However, these characteristics of player behavior in RTS games have not been investigated yet, thus, this is the main motivation of this paper. In particular, we introduce a method that can identify the war periods in real-time strategy game sessions based on non-intrusive measurements thus, it is possible to analyze a vast number of game plays. The paper also presents some early results comparing the real and gaming worlds.
Molecular Dynamics Simulation at High Sodium Chloride Concentration: Toward the Inactive Conformation of the Human Adenosine A2A Receptor (2010)

The recently solved crystal structure of the human adenosine A2A receptor (hA2AR) shows the characteristics of a partially activated state. Experimental data suggests that high sodium chloride concentration shifts hA2AR to the inactive state. We found that molecular dynamics simulations at high sodium chloride concentration result in an inactive form of hA2AR reflected in the reformation of the “ionic lock” (Arg102(3.50)−Glu228(6.30)) as well as in the reduction of the αC−αC distance between the intracellular sides of transmembrane helices 3 and 6 (TM3 and TM6). Interestingly, no such stabilization effect was observed at physiological concentrations. Our results suggest that the effect of high sodium chloride concentration might be exploited to generate an inactive state of hA2AR, which is more favorable for identifying pharmacologically relevant antagonists or inverse agonists.
Optically stimulated electron emission analysis of surface contamination levels on epoxy composites and effect on failure mode of adhesively bonded specimens (2019)

Adhesive bonding is adversely affected by contamination on the adherend surfaces. Various surface monitoring techniques have been developed to assure that surfaces are sufficiently free from those contaminants, which can be adsorbed on to the adherend surfaces prior to applying the adhesive and degrade bond performance. Contaminants, even at low concentrations, can pose a risk to adhesive bonding and the durability of the bonded structure. It remains a challenge to measure residual surface concentrations of critical contaminant molecules (e.g. molecules from mold release agents) by current surface control procedures. Recently, we have made advances in an existing technique, optically stimulated electron emission (OSEE), originally developed for detection of contamination on metallic surfaces. Improvements in instrument design and in measurement analysis have extended this measurement modality to low levels of molecular species of contaminants on carbon fiber reinforced polymer (CFRP) materials. In this work, we present the basics of the measurement analysis and give some typical measurement results on smooth and laser ablated surfaces. We confirm the mercury spectral absorption mechanism of the contaminant species polydimethylsiloxane (PDMS), a major component of silicone-based mold release agents. Effects of PDMS levels on adhesive bond performance through analysis of double cantilever beam (DCB) testing is shown. Service life implications from failure modes of adhesive bonding onto PDMS-contaminated surfaces are made.
Supplementary Table 2 from Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis (2023)

&lt;p&gt;Variant and mutation calling&lt;/p&gt;
Appendix 2: Definition of Terms (1994)

Appendix 2: Definition of Terms" ablationremoval of material from a surface by application of energy, often from a abrasion resistanceability of a material to resist surface wear.activation energyminimum energy necessary for a reaction to proceed via an "activated complex" or transition state.active componentselectronic components, such as transistors, diodes, electron tubes, and thyristors that operate on an applied electrical signal to change their basic characteristics, e.g., rectification, amplification, and switching.pulsed laser.additive processprocess for obtaining conductive patterns by deposition.adhesionability of a conductor or insulator material to withstand a force attempting to adsorptionsee chemisorb and physisorb alloy -(a) any of a large number of substances having metallic properties and consisting of two or more usually metallic elements; (b) to make or melt an alloy.ambientenvironment that surrounds and contacts a system or component.amphoterichas both acidic and basic properties.anisotropicexhibiting different properties when tested along axes in different directions; in magnetics, capable of being magnetized more readily in one direction than in a transverse direction.accelerating reactive ions towards substrates which results in etching in the direction of the ion velocity with no lateral removal of material.specific product.separate it from the substrate.anisotropic etchingetching of a material in one direction, generally achieved by application-specific integrated circuitan integrated circuit chip customized for a aspect ratioratio of vertical dimension to horizontal dimension of a hole diameter.ballistic transporttransport of a material to a surface from a source without gas-phase barrier layerssee diffusion barrier.base metalnonprecious metal from which a connector, contact, or other metal collisions.accessory is made and on which one or more metals or coatings may be deposited.bipolardevice in which both majority and minority carriers are present; for integrated circuits, describes a specific type of construction.Bipolar and metaloxide semiconductor (MOS) are the most common types of integrated circuits (see also metal-oxide semiconductor).blanket depositiondeposition of a material over the entire surface of a substrate.
Magnetic resonance imaging and measurement of blood flow. (1994)

Blood flow can be shown as a negative image with magnetic resonance spin-echo techniques or as a positive image with gradient-echo techniques. Phase contrast refers to techniques where structures can be seen because of flow-induced phase shifts. These techniques can show the presence (slow flow) and also the direction of flow. Gradient-echo techniques--including phase-contrast versions--can be used with cardiac synchronization to obtain multiple images during the cardiac cycle. These images can be viewed in a movie or cine format to provide dynamic information about blood flow. Blood flow can be measured by using contrast media in boluses or even more elegantly with phase-contrast methods. Clinical applications of flow measurements are growing rapidly. Phase-contrast or gradient-echo techniques can be used to create magnetic resonance angiography, which was first used to study the carotid bifurcation and intracranial circulation and is now being used throughout the body.
A Simple Path-Loss Prediction Model for HVAC Systems (2004)

In this paper, we present a simple path-loss prediction model for link budget analysis in indoor wireless local area networks that use heating, ventilation, and air conditioning (HVAC) cylindrical ducts in the 2.4-2.5-GHz industrial, scientific, and medical band. The model we propose predicts the average power loss between a transmitter-receiver pair in an HVAC duct network. This prediction model greatly simplifies the link budget analysis for a complex duct network, making it a convenient and simple tool for system design. The accuracy of our prediction model is verified by an extensive set of experimental measurements.
Lysyl oxidase regulates actin filament formation through the p130Cas/Crk/DOCK180 signaling complex (2006)

We have previously demonstrated that lysyl oxidase (LOX) is expressed in invasive breast cancer cells compared to poorly invasive cells. Additionally, we have recently shown that LOX regulates cell migration, a key step in the invasion process, through a hydrogen peroxide-dependent mechanism involving the focal adhesion kinase (FAK)/Src signaling complex. Here we further elucidate the role of LOX in cell motility/migration by examining the role of LOX in actin filament polymerization. We demonstrate that inhibition of LOX leads to an increase in phalloidin staining, directly associated with an increase in actin stress fiber formation. This increase in staining was confirmed by activity assays showing an increase in Rho activity with decreased LOX activity. Additionally, Rac and Cdc42 activity decreased with the reduction in LOX activity. Taken together, these data demonstrate a loss of a motogenic phenotype with decreased LOX activity. Finally, in order to elucidate the mechanism by which LOX regulates actin polymerization, we have demonstrated that LOX facilitates p130(Cas) phosphorylation, which allows for the binding to CAS related kinase (Crk) and formation of the p130(Cas)/Crk/DOCK180 signaling complex. Formation of this complex leads to an increase in Rac-GTP, which decreases actin stress fiber formation and increases formation of lamellipodium. These data demonstrate that LOX regulates cell motility/migration through changes in actin filament polymerization, which involve the regulation of the p130(Cas)/Crk/DOCK180 signaling pathway. Elucidating the role of LOX in the regulation of cell motility will allow the development of more effective therapeutic strategies to treat invasive/metastatic breast cancer.
Controlling Listeria monocytogenes on ready-to-eat poultry products using carboxymethylcellulose film coatings containing green tea extract (GTE) combined with nisin and malic acid (2007)

The ability to control Listeria monocytogenes on ready-to-eat poultry products using carboxymethyl-cellulose film coatings containing green tea extract (GTE), malic acid (M), nisin (N), and their combinations was evaluated. The antimicrobials (GTE: 1.0%, nisin: 10,000 IU/g, malic acid: 1.0%) were incorporated alone or in combination into a carboxymethyl cellulose film coating. Pre-inoculated, fully cooked chicken pieces (~1g, 1cm x 1cm x 1cm) were coated with the film solution. The coated chicken pieces were stored at 4°C and the inhibitory activity against Listeria monocytogenes was evaluated at 0, 7, 14, 21, and 28 days. The highest inhibitory activity was found in the sample containing GTE, nisin, and malic acid in combination with a reduction of 3.3 log CFU/mL. These data demonstrate that GTE—combined with nisin and malic acid and incorporated into a carboxymethyl-cellulose film coating, multiple-hurdle technology—is effective in inhibiting L. monocytogenes growth on fully cooked chicken pieces at 4°C. Research in the area of finding natural antimicrobials to aid in the prevention of food-borne illnesses is necessary to improve safety and shelf life of products such as ready-to-eat meats. This project provides an effective combination of natural anti-microbials to control L. monocytogenes in ready-to-eat chicken pieces.
Current Interruption Properties of Self-Recovering Micro Fuse by Applying a Pulse-Shaped Overcurrent (2008)

This paper deals with the current interruption properties of self-recovering micro fuse (SRF) by applying a pulse-shaped overcurrent. The current interruption operation, i.e. the OFF state transition by flowing overcurrent, is one of the most important operations for SRF device, along with the self-recovering operation and the mechanical fuse operation as a additional function. Consequently, we successfully achieved the current interruption operation of SRF device under pulse-shaped current, and investigated fundamental interruption properties such as breaking current and breaking time. Also, we discussed the interruption mechanism in view of heat generation and electromagnetic force.
Medium-Frequency Transformer Scaling Laws: Derivation, Verif ication, and Critical Analysis (2020)

Medium-frequency transformers (MFTs) are one of the fundamental building blocks of modern power electronic converters. The usage of increased frequencies leads to improved characteristics, i.e., efficiency and power density (volumetric and gravimetric) but also to design challenges and constraints. This paper reviews the analytical modeling of MFTs. More particularly, the mapping between the design space and the performance space is analyzed. It is found that wide regions of the design space are mapped to a narrow region in the performance space, i.e., the optimum is flat and designs with very different parameters features similar performances (design space diversity). Scaling laws are derived for optimal MFTs operated at different power ratings and power densities, which provide a comprehensive and general insight on the achievable performances. In a next step, the results obtained with the analytical model are compared to numerical simulations. It is concluded that the derived scaling laws capture qualitatively and quantitatively the behavior of MFTs, but should be used with caution for accurate design processes.
[Early diagnosis and early treatment of a patient with intralobular pulmonary sequestration]. (1983)

A report is given on a case of intralobar pulmonary sequestration (I. L. S), which was hospitalized with the suspect diagnosis of a cavernous tuberculous infection. The 3 6/12-year-old boy was suffering of recurrent respiratory infections. These led finally to a thoracic X-ray control. X-rays showed a cystic malformation of the left lower lobe. This localisation drew our attention especially to I. L. S. after exclusion of various other diagnostic possibilities. For this reason a retrograde aortography was carried out and showed an abnormal blood supply of the cyst from the thoracic aorta. So this procedure established the diagnosis. Because of the high pulmonary and cardiac complication rate, a surgical treatment, as early as possible, is the therapy of choice. In our case the segmental resection was sufficient.
All-PM coherent 205 µm Thulium/Holmium fiber frequency comb source at 100 MHz with up to 05 W average power and pulse duration down to 135 fs (2013)

We report on a dual output all-PM fiber laser system running at 100 MHz repetition rate offering coherent broadband and narrowband pulses centered at 2.05 µm with a spectral FWHM bandwidth of 60 nm and 1.5 nm at up to 360 mW and 500 mW, respectively. The broadband pulses are compressed down to 135 fs. The multi-stage double-clad amplifier based on Tm/Ho codoping is seeded by a supercontinuum light source, spanning from around 1 µm up to 2.4 µm.
Tailor-Made Mutations in Arabidopsis Using Zinc Finger Nucleases (2013)

Zinc finger nucleases (ZFNs) are proteins engineered to make site-specific double-strand breaks (DSBs) in a DNA sequence of interest. Imprecise repair of the ZFN-induced DSBs by the nonhomologous end-joining (NHEJ) pathway results in a spectrum of mutations, such as nucleotide substitutions, insertions, and deletions. Here we describe a method for targeted mutagenesis in Arabidopsis with ZFNs, which are engineered by context-dependent assembly (CoDA). This ZFN-induced mutagenesis method is an alternative to other currently available gene knockout or knockdown technologies and is useful for reverse genetic studies.
Dynamic Packet Offload Tuning in Packet-Optical Network Scenarios (2013)

In packet-opto scenarios, packet offload towards the optical layer enables transit traffic to avoid packet processing in intermediate nodes saving costs and power. A strategy to dynamically tune the offload level is presented and simulated.
Bayesian ANN estimates of three-class ideal observer decision variables for classification of mammographic masses (2003)

We are using Bayesian artificial neural networks (BANNs) to classify mammographic masses. We investigated whether a BANN can estimate ideal observer decision variables to distinguish malignant, benign, and false-positive computer detections. Five features were calculated for 143 malignant and 125 benign mass lesions, and for 1049 false-positive computer detections, in 596 mammograms randomly divided into a training and testing set. A BANN was trained on the training set features and applied to the testing set features. We then used a known relation between three-class ideal observer decision variables and that used by a two-class ideal observer when two of three classes are grouped into one class, giving one decision variable for distinguishing malignant from non-malignant detections, and a second for distinguishing true-positive from false-positive computer detections. For comparison, we pooled the training data into two classes in the same two ways and trained two-class BANNs for these two tasks. The three-class BANN decision variables were essentially identical in performance to the specifically trained two-class BANNS. This is consistent with the theoretical observation that three-class ideal observer decision variables are directly related to those used by a two-class ideal observer.