gebhart/patrepeval huggingface dataset:
Maternal immunization against Group B streptococcus: World Health Organization research and development technological roadmap and preferred product characteristics (2018)

Group B streptococcus, found in the vagina or lower gastrointestinal tract of about 10-40% of women of reproductive age, is a leading cause of early life invasive bacterial disease, potentially amenable to prevention through maternal immunization during pregnancy. Following a consultation process with global stakeholders, the World Health Organization is herein proposing priority research and development pathways and preferred product characteristics for GBS vaccines, with the aim to facilitate and accelerate vaccine licensure, policy recommendation for wide scale use and implementation.
Anti-TNF-α antibody allows healing of joint damage in polyarthritic transgenic mice (2002)

Anti-tumor-necrosis-factor-alpha (TNF-alpha) monoclonal antibody was used to treat Tg197 transgenic mice, which constitutively produce human TNF-alpha (hTNF-alpha) and develop a progressive polyarthritic disease. Treatment of both young (7- or 8-week-old) and aged (27- or 28-week-old) mice commenced when at least two limbs showed signs of moderate to severe arthritis. The therapeutic efficacy of anti-TNF-alpha antibody was assessed using various pathological indicators of disease progression. The clinical severity of arthritis in Tg197 mice was significantly reduced after anti-TNF-alpha treatment in comparison with saline-treated mice and in comparison with baseline assessments in both young and aged mice. The treatment with anti-TNF-alpha prevented loss of body weight. Inflammatory pathways as reflected by elevated circulating hTNF-alpha and local expression of various proinflammatory mediators were all diminished by anti-TNF-alpha treatment, confirming a critical role of hTNF-alpha in this model of progressive polyarthritis. More importantly, the amelioration of the disease was associated with reversal of existing structural damage, including synovitis and periosteal bone erosions evident on histology. Repair of cartilage was age dependent: reversal of cartilage degradation after anti-TNF-alpha treatment was observed in young mice but not in aged mice.
No need to war-drive (2012)

We propose UnLoc, an unsupervised indoor localization scheme that bypasses the need for war-driving. Our key observation is that certain locations in an indoor environment present identifiable signatures on one or more sensing dimensions. An elevator, for instance, imposes a distinct pattern on a smartphone's accelerometer; a corridor-corner may overhear a unique set of WiFi access points; a specific spot may experience an unusual magnetic fluctuation. We hypothesize that these kind of signatures naturally exist in the environment, and can be envisioned as internal landmarks of a building. Mobile devices that "sense" these landmarks can recalibrate their locations, while dead-reckoning schemes can track them between landmarks. Results from 3 different indoor settings, including a shopping mall, demonstrate median location errors of 1:69m. War-driving is not necessary, neither are floorplans the system simultaneously computes the locations of users and landmarks, in a manner that they converge reasonably quickly. We believe this is an unconventional approach to indoor localization, holding promise for real-world deployment.
Characterization of polymers of adenosine diphosphate ribose generated in vitro and in vivo (1987)

Methods have been developed and applied to determine the size and branching frequency of polymers of ADP-ribose synthesized in nucleotide-permeable cultured mouse cells and in intact cultured cells. Polymers were purified by affinity chromatography with a boronate resin and were fractionated according to size molecular sieve high-performance liquid chromatography. Fractions were enzymatically digested to nucleotides, which were separated by strong anion exchange high-performance liquid chromatography. From these data, average polymer size and branching frequency were calculated. A wide range of polymer sizes was observed. Polymers as large as 190 residues with at least five points of branching per molecule were generated in vitro. Polymers of up to 67 residues containing up to two points of branching per molecule were isolated from intact cells following treatment with the DNA alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine. Cells treated with hyperthermia prior to DNA damage contained polymers of an average maximum size of 244 residues containing up to six points of branching per molecule. The detection of large polymers of ADP-ribose in intact cells suggests that alterations in chromatin organization effected by poly(ADP-ribosylation) may extend beyond the covalently modified proteins and very likely involve noncovalent interactions of poly(ADP-ribose) with other components of chromatin.
Advanced Industrial Wireless Sensor Networks and Intelligent IoT (2018)

Examines the market for wireless sensor networks in the era and expansion of the Internet of Things. Over the past decade, the fast expansion of the Internet of Things (IoT) paradigm and wireless communication technologies has raised many scientific and engineering challenges that call for ingenious research efforts from both academia and industry. The IoT paradigm now covers several technologies beyond RFID and wireless sensor networks (WSNs). In fact, the number of potential application fields has already exceeded expectations. According to Cisco IBSG, more than 50 billion devices are expected to be connected to the Internet by 2020, with around 20 percent from the industry sector. Therefore, integrating the IoT concept and industrial WSNs (IWSNs) is an attractive choice for industrial processes, which may optimize operational efficiency, automation, maintenance, and rationalization. Moreover, IoT ensures large-scale interconnection between machines, computers, and people, enabling intelligent industrial operations. This emergent technological evolution has led to what has become the Industrial IoT (IIoT). IIoT will bring promising opportunities, along with new challenges.
Laplace Distribution Based Lagrangian Rate Distortion Optimization for Hybrid Video Coding (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> In today's hybrid video coding, Rate-Distortion Optimization (RDO) plays a critical role. It aims at minimizing the distortion under a constraint on the rate. Currently, the most popular RDO algorithm for one-pass coding is the one recommended in the H.264/AVC reference software. It, or HR-<formula formulatype="inline"><tex Notation="TeX">$\lambda $</tex></formula> for convenience, is actually a kind of universal method which performs the optimization only according to the quantization process while ignoring the properties of input sequences. Intuitively, it is not efficient all the time and an adaptive scheme should be better. Therefore, a new algorithm Lap-<formula formulatype="inline"> <tex Notation="TeX">$\lambda $</tex></formula> is presented in this paper. Based on the Laplace distribution of transformed residuals, the proposed Lap-<formula formulatype="inline"><tex Notation="TeX">$\lambda $</tex></formula> is able to adaptively optimize the input sequences so that the overall coding efficiency is improved. Cases which cannot be well captured by the proposed models are considered via escape methods. Comprehensive simulations verify that compared with HR-<formula formulatype="inline"><tex Notation="TeX">$\lambda $</tex> </formula>, Lap-<formula formulatype="inline"><tex Notation="TeX">$\lambda $</tex></formula> shows a much better or similar performance in all scenarios. Particularly, significant gains of 1.79 dB and 1.60 dB in PSNR are obtained for slow sequences and B-frames, respectively. </para>
3D video segmentation using point distance histograms (2005)

Similar to 2D video segmentation, 3D video segmentation is to divide the 3D video in temporal domain into a set of meaningful and manageable segments (shots) that are used as basic elements for indexing. This paper proposes a temporal segmentation method for 3D video for the first time as far as we know. Point distance histograms are used considering the tradeoff between computational cost and effectiveness. In order to reflect the real motion of 3D object, three fixed points are selected, which can avoid what we call "the same sphere problem." And simulation results on total 285 frames, which are composed of four different sequences, show our method is very effective.
Supplemental Table 1 from Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor (2023)

&lt;p&gt;In vitro kinase inhibition by DiscoverX KinomeScan assay. For details see (19)&lt;/p&gt;
Effects of sample preparation on concentrations of cyclosporin A measured in plasma. (1984)

Because cyclosporin A rapidly changes its distribution in blood with changes in temperature, sample preparation affects results for it as measured in plasma. If whole blood is stored at either 4 degrees C or room temperature, results for cyclosporin A in the plasma are lower than in whole blood stored at 37 degrees C and centrifuged at this temperature. Re-equilibration of the former to 37 degrees C before cells are removed increases the analytical recovery of cyclosporin A in plasma; the optimal equilibration interval is 30 min. Use of such re-equilibration, followed by immediate centrifugation at room temperature, increases values obtained for cyclosporin in plasma by 60 to 65% over those determined after non-temperature-standardized collection procedures, but does not significantly improve the correlation between values for plasma and whole blood. Hematocrit and concentrations of cyclosporin A in plasma are inversely related. Correction for hematocrit improves the correlation between results for plasma and whole blood.
Morphological Study on Room‐Temperature‐Cured PMMA‐Grafted Natural Rubber‐Toughened Epoxy/Layered Silicate Nanocomposite (2012)

A morphological study was conducted on ternary systems containing epoxy, PMMA‐grafted natural rubber, and organic chemically modified montmorillonite (Cloisite 30B). Optical microscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive X‐ray (EDX), and wide‐angle X‐ray diffraction (WAXD) analysis were used. The following four materials were prepared at room temperature: cured unmodified epoxy, cured toughened epoxy, cured unmodified epoxy/Cloisite 30B nanocomposites, and cured toughened epoxy/Cloisite 30B nanocomposites. Mixing process was performed by mechanical stirring. Poly(etheramine) was used as the curing agent. The detailed TEM images revealed co‐continuous and dispersed spherical rubber in the epoxy‐rubber blend, suggesting a new proposed mechanism of phase separation. High‐magnification TEM analysis showed good interactions between rubber and Cloisite 30B in the ternary system. Also, it was found that rubber particles could enhance the separation of silicates layers. Both XRD and TEM analyses confirmed that the intercalation of Cloisite 30B was achieved. No distinct exfoliated silicates were observed by TEM. Aggregates of layered silicates (tactoids) were observed by SEM and EDX, in addition to TEM at low magnification. EDX analysis confirmed the presence of organic and inorganic elements in the binary and ternary epoxy systems containing Cloisite 30B.
Azithromycin Is as Effective as and Better Tolerated Than Erythromycin Estolate for the Treatment of Pertussis (2004)

In this large, multicenter, randomized trial, we found that azithromycin is as effective as erythromycin estolate for the treatment of pertussis in children. Gastrointestinal adverse events were much more common with erythromycin treatment than azithromycin. Compliance with therapy was markedly better with azithromycin than with erythromycin in this study.
Thermal Design of a Hierarchical Radially Expanding Cavity for Two-Phase Cooling of Integrated Circuits (2015)

A major challenge in the implementation of evaporative two-phase liquid-cooled ICs with embedded fluid microchannels/cavities is the high pressure drops arising from evaporation-induced expansion and acceleration of the flowing two-phase fluid in small hydraulic diameters. Our ongoing research effort addresses this challenge by utilizing a novel hierarchical radially expanding channel networks with a central embedded inlet manifold and drainage at the periphery of the chip stack. This paper presents a qualitative description of the thermal design process that has been adopted for this radial cavity. The thermal design process first involves construction of a system-level pressure-thermal model for the radial cavity based on both fundamental experiments as well as numerical simulations performed on the building block structures of the final architecture. Finally, this system-level pressure-thermal model can be used to identify the design space and optimize the geometry to maximize thermal performance, while respecting design specifications. This design flow presents a good case study for electrical-thermal co-design of two-phase liquid cooled ICs.
Control of interlayer physics in 2H transition metal dichalcogenides (2017)

It is assessed in detail both experimentally and theoretically how the interlayer coupling of transition metal dichalcogenides controls the electronic properties of the respective devices. Gated transition metal dichalcogenide structures show electrons and holes to either localize in individual monolayers, or delocalize beyond multiple layers—depending on the balance between spin-orbit interaction and interlayer hopping. This balance depends on the layer thickness, momentum space symmetry points, and applied gate fields. The design range of this balance, the effective Fermi levels, and all relevant effective masses is analyzed in great detail. A good quantitative agreement of predictions and measurements of the quantum confined Stark effect in gated MoS2 systems unveils intralayer excitons as the major source for the observed photoluminescence.
Pyrido[2,3-d]pyrimidin-7-one Inhi-bitors of Cyclin-Dependent Kinases. (2001)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionPyrido[2,3-d]pyrimidin-7-one Inhi-bitors of Cyclin-Dependent Kinases.Mark Barvian, Diane H. Boschelli, Jennifer Cossrow, Ellen Dobrusin, Ali Fattaey, Alex Fritsch, David Fry, Patricia Harvey, Paul Keller, Michelle Garrett, Frances La, Wilbur Leopold, Dennis McNamara, Maire Quin, Susanne Trumpp-Kallmeyer, Peter Toogood, Zhipei Wu, and Erli ZhangCite this: J. Med. Chem. 2001, 44, 6, 1016Publication Date (Web):February 14, 2001Publication History Published online14 February 2001Published inissue 1 March 2001https://pubs.acs.org/doi/10.1021/jm010012ahttps://doi.org/10.1021/jm010012acorrectionACS PublicationsCopyright © 2001 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views607Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (14 KB) Get e-Alertsclose Get e-Alerts
Secure Distributed Set Membership through Secret Sharing. (2015)

Abstract not provided.
Regulation of bacterial gene expression by riboswitch RNAs (2011)

Malignant melanoma is refractory to various chemotherapeutics including antitubulin agents such as paclitaxel. Previous studies have suggested a link between βIII-tubulin overexpression and paclitaxel resistance through alterations in the properties of the mitotic spindle. We found that paclitaxel treatment induced temporary mitotic arrest in 7 melanoma cell lines irrespective of the βIII-tubulin level, suggesting that βIII-tubulin had no significant influence on spindle properties. On the other hand, the amount of BCL2, an anti-apoptotic protein, was well correlated with paclitaxel resistance. Treatment of the paclitaxel-resistant cell lines with ABT-737, an inhibitor of BCL2 and BCLxL, or simultaneous knock-down of BCL2 and BCLxL dramatically increased the cells' sensitivity, while knock-down of MCL1, another member of the BCL2 family, had only a minimal effect. Our results suggest that the paclitaxel sensitivity of melanoma cells is attributable to apoptosis susceptibility rather than a change in spindle properties and that BCL2 and BCLxL play a pivotal role in the former.
Wave theoretical analysis of spot excitation near‐field scanning method for optical fiber index profiling: Effect of finite spot size (1982)

A family of near‐field spot excitation or detection techniques have recently been developed to measure the refractive index profile of optical fibers. The present paper discusses the effect of finite spot size of the illuminating beam on the accuracy of the reconstructed profile. A wave theoretical analysis is performed, and a series of numerical examples are given. Experiments of the spot excitation near‐field scanning method are performed for a nearly parabolic index fiber, resulting in a satisfactory agreement with the numerical analysis. Furthermore, a quantity is introduced which is a function of the refractive index, wavelength, and spot size of the illuminating beam. This quantity serves to determine the suitable spot size for measuring the optical fibers having different parameters.
The Biological Sludge Reduction by anaerobic/aerobic cycling (2010)

An activated sludge system that incorporates a sidestream anaerobic bioreactor, called the Cannibal process, was the focus of this study. A prior study of this process (Novak et al., 2007) found that this system generated about 60% less solids than conventional activated sludge without any negative effects on the effluent quality. Although that study showed substantial solids reduction, questions remain concerning the specific mechanism(s) that account for the solids loss. In this study, the mechanisms that account for the loss of biological solids was the focus of the investigation. The first part of this study was conducted to evaluate those effects in terms of the role of iron in the influent wastewater and feeding patterns on the performance of the Cannibal system. It was found that the Cannibal system with high iron in the influent produced less biological solids than the system receiving low iron. The data also showed that the Cannibal system operated under fast feed (high substrate pressure) produced much less solids than the system with slow feed (low substrate pressure). The high substrate pressure was achieved by feeding the influent wastewater to the Cannibal system over a short time period so that the substrate concentration would initially peak and then decline as degradation occurred. This is called “fast feed.” For low substrate pressure, the influent was added slowly so the substrate concentration remained low at all times. This is called “slow feed.” Later, an attempt to increase substrate pressure in the slow feed Cannibal system was conducted by either manipulating the aeration patterns or adding a small reactor in front of the main reactor (selector). It was found that either interrupting aeration in the aerobic reactor or providing a small aerobic reactor in front of the main reactor resulted in an increase in solids reduction. The second part of this study was to investigate the mechanisms of floc destruction in the fast and the slow feed Cannnibal systems. It was found that higher accumulation of biopolymers (proteins and polysaccharides) occurred in the fast feed system and this was associated with a greater solids reduction in the fast than the slow feed system. In addition, more protein hydrolysis and more Fe(III)-reducing microorganism activity in the fast feed environment were found to be factors in higher solids reduction. The last part of this study was to investigate the structure of the Cannibal sludge flocs generated under the fast and the slow feed conditions. It was found that the readily biodegradable (1 kDa.) protein is larger in the flocs from the fast feed than the slow feed Cannibal system. This resulted in higher floc destruction in the fast feed condition.
Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology (2015)

Our study suggests that the previously reported link between periodontitis and RA could be accounted for by P gingivalis infection, and we conclude that P gingivalis is a credible candidate for triggering and/or driving autoimmunity and autoimmune disease in a subset of RA patients.
Linear and nonlinear impairment mitigation in a Nyquist spaced DP-16QAM WDM transmission system with full-field DBP (2014)

A RRC filter with a 0.1% roll-off factor reduces the impact of linear crosstalk-induced penalty in a Nyquist spaced 10GBd DP-16QAM transmission system with a net ISD of 7.47(b/s)/Hz and the maximum reach is extended to 1940km using full-field DBP.
Monoval‐LdC: Efficient Prodrug of 2′‐Deoxy‐β‐L‐cytidine (L‐dC), a Potent and Selective anti‐HBV Agent (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Cancer of the Nasal Cavity and Paranasal Sinuses:A Clinico-pathological Study of 277 Patients (1997)

In the period 1963-1991, a total of 277 consecutive patients with malignant tumours of the nasal cavity and paranasal sinuses were treated at Aarhus University Hospital. The major histological types included squamous cell carcinoma (46%), lymphoma (14%), adenocarcinoma (13%), and malignant melanoma (9%). Kaplan-Meier estimates of 5-year corrected survival (death from cancer) showed the best prognosis for adenoid cystic carcinoma (87%), adenocarcinoma (65%) and lymphoma (56%), and the poorest prognosis for undifferentiated carcinoma (17%) and malignant melanoma (24%). The 5-year corrected survival for squamous cell carcinoma was 35%. Of the 180 patients with treatment failure, the vast majority occurred locally (n = 166); a minor proportion was regional (n = 23) or distant (n = 30). For the 195 patients with carcinoma, the following parameters were of statistical prognostic significance (5-year corrected survival): histological differentiation (moderate-well 65% vs. poor 22%), primary T-site (nasal cavity 56% vs. maxillary antrum 39% vs. other sinuses 24%), tumour stage (T2 68% vs. T3 37% vs. T4 29%), nodal stage (N0 48% vs. N1-3 21%), treatment (radiotherapy + surgery 56% vs. radiation alone 35%).
The effect of medical students’ gender, ethnicity and attitude towards poetry-reading on the evaluation of a required, clinically-integrated poetry- based educational intervention (2014)

According to students' evaluation, a format of integrated, obligatory poetry-based intervention may be suitable for enhancing "student-patient" aims in heterogeneous student populations. The higher evaluation of the "patient-student" effect among Arab and Druze as compared to Jewish students may be related to cultural differences in the perception of this component of medical professionalism. Further research can provide insight into the effect of cultural and ethnic differences on actual empathy of medical students in patient encounters.