gebhart/patrepeval huggingface dataset:
In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors. (1996)

Anergy is a major mechanism to ensure antigen-specific tolerance in T lymphocytes in the adult. In vivo, anergy has mainly been studied at the cellular level. In this study, we used the T-cell-activating superantigen staphylococcal enterotoxin A (SEA) to investigate molecular mechanisms of T-lymphocyte anergy in vivo. Injection of SEA to adult mice activates CD4+ T cells expressing certain T-cell receptor (TCR) variable region beta-chain families and induces strong and rapid production of interleukin 2 (IL-2). In contrast, repeated injections of SEA cause CD4+ T-cell deletion and anergy in the remaining CD4+ T cells, characterized by reduced expression of IL-2 at mRNA and protein levels. We analyzed expression of AP-1, NF-kappa B, NF-AT, and octamer binding transcription factors, which are known to be involved in the regulation of IL-2 gene promoter activity. Large amounts of AP-1 and NF-kappa B and significant quantities of NF-AT were induced in SEA-activated CD4+ spleen T cells, whereas Oct-1 and Oct-2 DNA binding activity was similar in both resting and activated T cells. In contrast, anergic CD4+ T cells contained severely reduced levels of AP-1 and Fos/Jun-containing NF-AT complexes but expressed significant amounts of NF-kappa B and Oct binding proteins after SEA stimulation. Resolution of the NF-kappa B complex demonstrated predominant expression of p50-p65 heterodimers in activated CD4+ T cells, while anergic cells mainly expressed the transcriptionally inactive p50 homodimer. These alterations of transcription factors are likely to be responsible for repression of IL-2 in anergic T cells.
Graphene Oxide-Supported Organo-Montmorillonite Composites for the Removal of Pb(II), Cd(II), and As(V) Contaminants from Water (2019)

The application of sorbent in solving the water pollution induced by heavy metals or metalloids is severely hindered by poor sorption performance and high cost, especially in simultaneous removal. Design and synthesis of nanocomposites as effective sorbents has been widely considered as a promising approach to address this problem. Herein, graphene oxide supported organo-montmorillonite composite (GO-OM) was prepared through a facile ultrasonic-assisted method for the first time and exhibited excellent synergetic adsorption behavior for mixed pollutants in aqueous solutions. Unlike previous studies, the simultaneous removal process can be well-described by the Freundlich and pseudo-second-order kinetic models. The sorption capacities of GO-OM are very high for both metal cations and oxyanionic groups, showing excellent potential in the removal of multiple contaminants. Our study also reveals that GO-OM has high recycling efficiency and good performance under a low level concentration. All results suggest that GO-OM can be used as effective and ecofriendly sorbents for the removal of combined pollutants in an aqueous environment. This work contributes to developing high-performance graphene materials with organic minerals and gives deep insight into simultaneous sorption of metal ions, which can be potentially extended to other multiple pollutants.
Chronotherapy and chronotoxicity of the cyclooxygenase-2 inhibitor, celecoxib, in athymic mice bearing human breast cancer xenografts. (2001)

Tumor growth response to the MTD at each HALO revealed that there was no clear relationship between dose administered and therapeutic response. COX-2 expression was not able to explain either the chronotherapy or the chronotoxicity results obtained.
A petri nets based design of cognitive radios using distributed signal processing (2009)

Reconfigurability for transceivers for wireless access networks like Bluetooth, WiMAX and W-LAN will become increasingly important. An appropriately flexible and reliable software architecture, allowing the concurrent processing of different controlling tasks for wireless terminals will hence be an important asset. Already during the 1980s reconfigurable receivers were developed for radio intelligence in the short wave range and the concept of software radio (SR) was born. A software defined radio (SDR) is a practical version of an SR: The received signals are sampled after a suitable band selection filter, usually in the base band or a low intermediate frequency band. The signal processing in both SR and SDR requires a considerable amount of concurrent processes. Since Petri nets (PNs) are both simple and strong tools for the description and the design of such concurrent processes, it is recommendable to deploy them for SDR. SDRs have paved the way towards cognitive radios (CRs), which are based on SDRs that additionally sense their environments, track changes, and react upon their findings. A CR is an autonomous unit in a communications environment that frequently exchanges information with the networks it is able to access as well as with other CRs. In this communication, the authors will introduce a realization concept for a CR which forms the basis of a hardware/firmware demonstrator developed by the authors. This demonstrator makes use of a digital signal processor (DSP) which forms the core of the design and flexibly programmable hardware accelerators based on field programmable gate arrays (FPGAs). The authors will describe the solution also in view of the recent developments of IEEE 802.22
Supplementary Table 1 from Biochemical Assays for the Discovery of TDP1 Inhibitors (2023)

&lt;p&gt;PDF - 65K, IC50 value table.&lt;/p&gt;
Multi-Ring Mirror-Based Narrow-Linewidth Widely-Tunable Lasers in Heterogeneous Silicon Photonics (2018)

We designed and fabricated narrow-linewidth widely-tunable lasers with multiring mirrors. A laser using a triple-ring mirror with 55 dB average SMSR across 30 nm tuning range and a record narrow linewidth of 17.5 kHz was demonstrated in heterogeneous silicon photonics.
Simplified calculation method of indoor optical impulse response based on recursive algorithm (2012)

A simplified method for the calculation of indoor wireless optical impulse response based on classical recursive algorithm is demonstrated. In the proposed algorithm, the optical characteristics of emitting and receiving elements have been used to reduce the complexity of computations while no sacrifice of accuracy is introduced. Theoretical investigation shows that the elementary computations for the third reflection decreases by nearly 50% in comparison with the one that utilizes the classical recursive algorithm, and can obtain a higher reduction percentage when more reflections are to be concerned.
Introduction to the Special Issue on Processing Reverberant Speech: Methodologies and Applications (2010)

The 17 papers in this special issue focus on the methodologies and applications of processing reverberant speech. The issue highlights some major aspects of the recent progress in the field.
Correction to Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models (2019)

ADVERTISEMENT RETURN TO ISSUEPREVCorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain ModelsKristopher K. AbneyKristopher K. AbneyMore by Kristopher K. Abney, Michael BubserMichael BubserMore by Michael Bubser, Yu DuYu DuMore by Yu Du, Krystian A. KozekKrystian A. KozekMore by Krystian A. Kozek, Thomas M. BridgesThomas M. BridgesMore by Thomas M. Bridges, Craig W. LindsleyCraig W. LindsleyMore by Craig W. Lindsleyhttp://orcid.org/0000-0003-0168-1445, J. Scott DanielsJ. Scott DanielsMore by J. Scott Daniels, Ryan D. MorrisonRyan D. MorrisonMore by Ryan D. Morrison, Kevin WickmanKevin WickmanMore by Kevin Wickman, Corey R. HopkinsCorey R. HopkinsMore by Corey R. Hopkinshttp://orcid.org/0000-0003-4958-1697, Carrie K. JonesCarrie K. JonesMore by Carrie K. Jones, and C. David Weaver*C. David WeaverMore by C. David Weaverhttp://orcid.org/0000-0002-6886-1195Cite this: ACS Chem. Neurosci. 2019, 10, 5, 2621Publication Date (Web):March 26, 2019Publication History Published online26 March 2019Published inissue 15 May 2019https://pubs.acs.org/doi/10.1021/acschemneuro.9b00165https://doi.org/10.1021/acschemneuro.9b00165correctionACS PublicationsCopyright © 2019 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1015Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (224 KB) Get e-AlertscloseSUBJECTS:Neurophysiology Get e-Alerts
Large-Scale Molecular Dynamics Study of Entangled Hard-Chain Fluids (1995)

Equilibrium molecular dynamics is used to simulate fluids comprised of chains of tangent hard spheres. Reptation theory predictions of segmental motion are compared with simulation results. In addition to the usual tube confinement, a second entanglement effect is observed. As the chain disengages from the tube, persistent interchain contacts cause a plateau in the segment mean-square displacement and subsequent accelerated diffusion. Associated with the plateau in the mean-square displacement is a corresponding delay in relaxation of the end-to-end vector as interior chain segments are extended during disentanglement.
Nucleotides, Part LXIII, New 2-(4-Nitrophenyl)ethyl(Npe)- and 2-(4-Nitrophenyl)ethoxycarbonyl(Npeoc)-Protected 2′-Deoxyribonucleosides and Their 3′-Phosphoramidites - Versatile Building Blocks for Oligonucleotide Synthesis (1999)

A series of new base-protected and 5′-O-(4-monomethoxytrityl)- or 5′-O-(4,4′-dimethoxytrityl)-substituted 3′-(2-cyanoethyl diisopropylphosphoramidites) and 3′-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidites] 52 – 66 and 67 – 82, respectively, are prepared as potential building blocks for oligonucleotide synthesis (see Scheme). Thus, 3′,5′-di-O-acyl- and N 2,3′-O,5′-O-triacyl-2′-deoxyguanosines can easily be converted into the corresponding O6-alkyl derivatives 6, 8, 10, 12, 14, and 16 by a Mitsunobu reaction using the appropriate alcohol. Mild hydrolysis removes the acyl groups from the sugar moiety (→ 9, 11, 13, 15, and 19 (via 18), resp.) which can then be tritylated (→ 38 – 42) and phosphitylated (→ 57 – 61) in the usual manner. N 2-[2-(4-nitrophenyl)ethoxycarbonyl]-substituted and N 2-[2-(4-nitrophenyl)ethoxycarbonyl]-O6-[2-(4-nitrophenyl)ethyl]-substituted 2′-deoxyguanosines 5 and 7, respectively, are synthesized as new starting materials for tritylation (→ 28, 35, and 37) and phosphitylation (→ 54, 56, 70, and 78). Various O4-alkylthymidines (see 20 – 24) are also converted to their 5′-O-dimethoxytrityl derivatives (see 43 – 47) and the corresponding phosphoramidites (see 62 – 66 and 79 – 82).
Multi-state decoding of point-and-click control signals from motor cortical activity in a human with tetraplegia (2007)

Basic neural prosthetic control of a computer cursor has been recently demonstrated by Hochberg et al. (2006) using the BrainGate system (Cyberkinetics Neurotechnology Systems, Inc.). While these results demonstrate the feasibility of intracortically-driven prostheses for humans with paralysis, a practical cursor-based computer interface requires more precise cursor control and the ability to "click" on areas of interest. Here we present the first practical point and click device that decodes both continuous states (e.g. cursor kinematics) and discrete states (e.g. click states) from a single neural population in human motor cortex. We describe a probabilistic multi-state decoder and the necessary training paradigms that enable point and click cursor control by a human with tetraplegia using an implanted microelectrode array. We present results from multiple recording sessions and quantify the point and click performance
Clinical conditions and risk factors for inhibitor‐development in patients with haemophilia: A decade‐long prospective cohort study in Japan, J‐HIS2 (Japan Hemophilia Inhibitor Study 2) (2022)

The J-HIS2 study has identified significant clinical variables associated with inhibitor-development in Japanese PwH, consistent with other global studies.
Double-Tensural Bistable Mechanisms (DTBM) With On-Chip Actuation and Spring-Like Post-Bistable Behavior (2005)

A set of mechanisms called Double Tensural Bistable Mechanisms (DTBM) is presented. DTBMs are fully compliant linear bistable mechanisms that have two bending segments that undergo tension loading. Five configurations of the DTBM are designed, fabricated using surface micromachining, and tested. Measured force and displacement are compared with finite element analysis (FEA) predictions. For two DTBM configurations, a novel post-switch, large-displacement, low-k linear spring behavior is predicted by the FEA models and verified through experimental testing. On-chip actuation of two devices is achieved using thermomechanical in-plane microactuators (TIMs). The DTBM mechanism set explores a relatively new design space for fully compliant micromechanisms, and mechanisms from this class have promise in such applications as shutter positioning, microvalves, electrical relays, inertial sensors and g/time switches.
5 GHz Lamb wave Wi-Fi channel filters (2022)

Lamb-wave resonators offer the possibility to adjust their resonance frequency by varying the period of their inter-digitated electrodes. Leveraging the high frequency operation of the first antisymmetric mode in thin film lithium niobate membranes, this opens perspectives towards the cointegration of several filters operating in the 4–7 GHz range on the same die. To demonstrate this, we designed and fabricated a set of channel filters for the 5 GHz Wi-Fi standard. Resonators exhibit frequencies varying from 5.1 to 5.6 GHz and electromechanical coupling ranging from 5.5 to 9% for electrodes pitches varying from 1.1 µm to 800 nm, with quality factors in the 400–600 range. 3 and 5-resonator ladder filters exhibit insertion losses close to 2 (resp. 4) dB and rejection of 20 (resp. 30) dB, mostly limited by the frequency positionning of the resonators and feedthrough capacitances.
2D Neutron Diffraction Imaging on an Ammonite (2014)

Materials Science Research Division, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki, 319-1195, Japan Information Technology System's Management and Operating Office, Center for Computational Science & e-Systems, Tokai, Ibaraki, 319-1195, Japan J-PARC Center, Japan Atomic Energy Agency, Tokai, Ibaraki, 319-1195, Japan Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), Tsukuba, Ibaraki, 305-0801, Japan
CHARACTERIZATION OF SECOND GENERATION ADVANCED DYNAMIC PYROELECTRIC FOCAL PLANE ARRAY (2010)

ABSTRACT The pyroelectric effect has been characterized for single-pixel elements consisting of strontium bismuth tantalate (SBT) ferroelectric material as the sensing element. The pixels include also a thermal insulating layer and an infrared (IR) absorber layer. These MEMS-less devices are operated in active mode, a technique that eliminates the need for a radiation chopper found in passive pyroelectric IR imagers. Test results of the SBT pixels of dimensions 7.5 μm × 7.5 μm to 200 μm × 200 μm have shown high endurance to polar cycling, high responsivity values, and very low noise-equivalent temperature difference for focal plane array applications. This paper describes and analyses the results of precursor 2 × 2 arrays using discrete sensing elements, the active detection mechanism, and its unique read-out electronics. A second-generation 32 × 32 pixels array being implemented to demonstrate the performance of a 1k-pixel array as precursor to larger size arrays is also described. The active mode detection, in addition to eliminating the use of a chopper, enables the dynamic partition of the array into pixel domains in which the pixel sensitivities in each domain can be adjusted independently. This unique feature in IR detection is not readily found in other types of IR imagers and can be applied to the simultaneous tracking of diverse contrast objects. By controlling the absorber material thickness, the arrays can be optimized for maximum response at specified wavelengths by means of quarter-wavelength interferometric technique.
FFTSVD: A Fast Multiscale Boundary-Element Method Solver Suitable for Bio-MEMS and Biomolecule Simulation (2006)

This paper presents a fast boundary-element method (BEM) algorithm that is well suited for solving electrostatics problems that arise in traditional and bio-microelectromechanical systems (bio-MEMS) design. The algorithm, FFTSVD, is Green's-function-independent for low-frequency kernels and efficient for inhomogeneous problems. FFTSVD is a multiscale algorithm that decomposes the problem domain using an octree and uses sampling to calculate low-rank approximations to dominant source distributions and responses. Long-range interactions at each length scale are computed using the FFT. Computational results illustrate that the FFTSVD algorithm performs better than precorrected-FFT (pFFT)-style algorithms or the multipole-style algorithms in FastCap.
2D Density Control of Micro-Particles using Kernel Density Estimation (2023)

We address the challenge of controlling the density of particles in two dimensions by manipulatin the electric field acting on the particles immersed in a dielectric fluid. An array of electrodes is used to control the electric field, which applies dielectrophoretic forces to achieve the desired pattern of particle density. To model the motion of a particle, we use a lumped, 2D, capacitive-based, and nonlinear model. We estimate the spatial dependence of the capacitances using electrostatic COMSOL simulations. We formulate an optimal control problem to determine the electrode potentials that will produce the desired particle density pattern. The loss function is defined in terms of the difference between the target density and the particle density at a specific final time. To estimate the particle density, we use a kernel density estimator (KDE) computed from the particle positions that vary with the electrode potentials. The effectiveness of our approach is demonstrated through numerical simulations that illustrate how the particle positions and electrode potentials change when shaping the particle density from a uniform to a Gaussian distribution.
Characterization and evaluation of inversion algorithms for MR elastography (2002)

Magnetic resonance elastography (MRE) can visualize and measure acoustic shear waves in tissue-like materials subjected to harmonic mechanical excitation. This allows the calculation of local values of material parameters such as shear modulus and attenuation. Various inversion algorithms to perform such calculations have been proposed. Under certain assumptions (discussed in detail), the problem reduces to local inversion of the Helmholtz equation. Three algorithms are considered to perform this inversion: Direct Inversion, Local Frequency Estimation, and Matched Filter. To study the noise sensitivity, resolution, and accuracy of these techniques, studies were conducted on synthetic and physical phantoms and on in-vivo breast data. All three algorithms accurately reconstruct shear modulus, demarcate differences between tissues, and identify tumors as areas of higher stiffness, but they vary in noise sensitivity and resolution. The Matched Filter, designed for optimal behavior in noise, provides the best combination of sharpness and smoothness. Challenges remain in pulse sequence design, delivering sufficient signal to certain areas of the body, and improvements in processing algorithms, but MRE shows great potential for non-invasive in vivo determination of mechanical properties.
Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes (2015)

As adjunct to insulin, dual SGLT1 and SGLT2 inhibition with sotagliflozin improved glycemic control and the CGM profile with bolus insulin dose reduction, weight loss, and no increased hypoglycemia in type 1 diabetes.
Chiral organometallic NADH mimics: preparation and X-ray crystal structure of racemic (RS)-[Fe(η5-C5H5)(CO)(PPh3)(1-methyl-1,4-dihydronicotinoyl)] and homochiral (R)-(–)-[Fe(η5-C5H5)(CO){PPh2(O-[(–)-menthyl])}(1-methyl-1,4-dihydronicotinoyl)] and asymmetric reduction of ethyl benzoylformate (1991)

The racemic complex (RS)-[Fe(η5-C5H5)(CO)(PPh3)(1-methyl-1,4-dihydronicotinoyl)] has been prepared and shown to function as a NADH mimic. An X-ray crystal structure revealed that one face of the 1,4-dihydronicotinoyl moiety is essentially blocked by the triphenylphosphine ligand. The homochiral complex (R)-(–)-[Fe(η5-C5H5)(CO)(PPh2(O-[(–)-menthyl])](1-methyl-1,4-dihydronicotinoyl)] possessing the sterically demanding chiral auxiliary [Fe(η5-C5H5)(CO){PPh2(O)-(–)menthyl)}] at C-3 has also been prepared and shown to reduce ethyl benzoylformate to ethyl mandelate in 52% enantiomeric excess by a combination of steric and chelation control.
Pyrene derivatives as fluorescent probes of conformation near the 3′ termini of polyribonucleotides (1977)

Abstract When pyrene butyric acid hydrazide or pyrene acetic acid hydrazide is attached to single‐strand RNA 3′ termini a red shift in absorbance and substantial hypochromicity are observed. A strong induced CD is seen and the fluorescence intensity is quenched by an order of magnitude. In double‐stranded samples, a further 10‐fold quenching of fluorescence is seen. Several lines of evidence suggest that the residual fluorescence of pyrene butyric acid hydrazide‐duplex conjugates arises from a minor species. The most likely possibility is dye reacted at a site other than the 3′ end. Some indication exists that 3′‐attached pyrene may perturb the relative stability of nearby duplex. Within the limits of this reservation, it appears that 3′‐pyrene conjugates may be rather useful for detecting the existence of duplex regions accessible to a dye at the 3′ end of complex RNAs.
Triplex Formation Between DNA and Mixed Purine-Pyrimidine PNA Analog withLysinesin Backbone (1997)

Abstract Melting UV experiments and mixing curves indicated slow triplex formation between lysine comprising PNA and DNA complement in 100mM Na+ solution.
Integrated circuits based on broadband pixel‐array metasurfaces for generating data‐carrying optical and THz orbital angular momentum beams (2023)

There is growing interest in using multiple multiplexed orthogonal orbital angular momentum (OAM) beams to increase the data capacity of communication systems in different frequency ranges. To help enable future deployment of OAM-based communications, an ecosystem of compact and cost-effective OAM generators and detectors is likely to play an important role. Desired features of such integrated circuits include generating and detecting multiple coaxial OAM beams, tunability of OAM orders, and operation over a wide bandwidth. In this article, we discuss the use of pixel-array-based metasurfaces as OAM transmitters and receivers for mode division multiplexing (MDM) communications in near-infrared (NIR) and terahertz (THz) regimes.