gebhart/patrepeval huggingface dataset:
Low Thermal Budget Ohmic Contact Formation by Laser Anneal (2016)

In this work, we demonstrate the possibility to achieve an ohmic contact using a low thermal budget applicable to backside processing after wafer thinning. The process window for laser annealing as a function of the thinning process is investigated. By laser melt annealing, we demonstrate the possibility for different silicide phases from pure nickel deposition on thinned 4H-SiC, formation of uniform carbon nanoclusters at the metal/SiC interface and recovery of thinning-induced defects. This has been demonstrated as a function of different thinning process and surface conditions.
Field-resolved spectroscopy in the molecular fingerprint region (2017)

Summary form only given. In this contribution we introduce field-resolved spectroscopy (FRS) in the molecular fingerprint region, as a time-domain method able to mitigate the above-mentioned limitations and providing several major advantages over state-of-the-art broadband infrared vibrational spectroscopy schemes. FRS takes advantage of recently developed sources of phase-coherent, broadband femtosecond MIR pulses [1] and the ability to sample their electric fields in time with electro-optical sampling (EOS) [1-3], see setup in Fig. 1a. The phase-coherent superposition of all MIR frequency components to an ultrashort pulse enables the confinement of the vibration excitation event to a time window of at most a few hundred femtoseconds, which is significantly shorter than the typical decay times of the excited vibrations under scrutiny. Sampling the resulting electric field therefore allows for an efficient temporal separation of the response emerging from the sample (free induction decay, FID) from the high-power ultrashort excitation, see Fig. 1b. Thus, the FID is detected in a MIR-background-free manner such that source intensity noise does not affect the instrument's ability to detect small absorptions. Furthermore, the dynamic range of detection is adjustable to the strength of the time-domain signal, rendering the scheme power-scalable up to the deformation/damage of the sample. Finally, the heterodyne detection via EOS readily provides the full phase information of the FID and, furthermore, represents one of the most sensitive detection schemes for infrared electric fields [3]. With the above-mentioned
Choroidal endothelial and macrophage gene expression in atrophic and neovascular macular degeneration (2022)

The human choroid is a heterogeneous, highly vascular connective tissue that dysfunctions in age-related macular degeneration (AMD). In this study, we performed single-cell RNA sequencing on 21 human choroids, 11 of which were derived from donors with early atrophic or neovascular AMD. Using this large donor cohort, we identified new gene expression signatures and immunohistochemically characterized discrete populations of resident macrophages, monocytes/inflammatory macrophages and dendritic cells. These three immune populations demonstrated unique expression patterns for AMD genetic risk factors, with dendritic cells possessing the highest expression of the neovascular AMD-associated MMP9 gene. Additionally, we performed trajectory analysis to model transcriptomic changes across the choroidal vasculature, and we identified expression signatures for endothelial cells from choroidal arterioles and venules. Finally, we performed differential expression analysis between control, early atrophic AMD, and neovascular AMD samples, and we observed that early atrophic AMD samples had high expression of SPARCL1, a gene that has been shown to increase in response to endothelial damage. Likewise, neovascular endothelial cells harbored gene expression changes consistent with endothelial cell damage and demonstrated increased expression of the sialomucins CD34 and ENCM, which were also observed at the protein level within neovascular membranes. Overall, this study characterizes the molecular features of new populations of choroidal endothelial cells and mononuclear phagocytes in a large cohort of AMD and control human donors.
Carbon Dots as Nanotherapeutics for Biomedical Application (2020)

Carbon nanodots are zero-dimensional spherical allotropes of carbon and are less than 10nm in size (ranging from 2-8nm). Based on their biocompatibility, remarkable water solubility, eco- friendliness, conductivity, desirable optical properties and low toxicity, carbon dots have revolutionized the biomedical field. In addition, they have intrinsic photo-luminesce to facilitate bio-imaging, bio-sensing and theranostics. Carbon dots are also ideal for targeted drug delivery. Through functionalization of their surfaces for attachment of receptor-specific ligands, they ultimately result in improved drug efficacy and a decrease in side-effects. This feature may be ideal for effective chemo-, gene- and antibiotic-therapy. Carbon dots also comply with green chemistry principles with regard to their safe, rapid and eco-friendly synthesis. Carbon dots thus, have significantly enhanced drug delivery and exhibit much promise for future biomedical applications. The purpose of this review is to elucidate the various applications of carbon dots in biomedical fields. In doing so, this review highlights the synthesis, surface functionalization and applicability of biodegradable polymers for the synthesis of carbon dots. It further highlights a myriad of biodegradable, biocompatible and cost-effective polymers that can be utilized for the fabrication of carbon dots. The limitations of these polymers are illustrated as well. Additionally, this review discusses the application of carbon dots in theranostics, chemo-sensing and targeted drug delivery systems. This review also serves to discuss the various properties of carbon dots which allow chemotherapy and gene therapy to be safer and more target-specific, resulting in the reduction of side effects experienced by patients and also the overall increase in patient compliance and quality of life.
Synthesis of .alpha.-carbalkoxy ene thiols: a class of tautomeric thiopyruvate derivatives. Application to griseoviridin (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleSynthesis of .alpha.-carbalkoxy ene thiols: a class of tautomeric thiopyruvate derivatives. Application to griseoviridinJohn Butera, Josephine Rini, and Paul HelquistCite this: J. Org. Chem. 1985, 50, 19, 3676–3678Publication Date (Print):September 1, 1985Publication History Published online1 May 2002Published inissue 1 September 1985https://pubs.acs.org/doi/10.1021/jo00219a064https://doi.org/10.1021/jo00219a064research-articleACS PublicationsRequest reuse permissionsArticle Views338Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Laparoscopy-assisted colon resection for mucosa-associated lymphoid tissue (MALT) lymphoma in the cecum. (2003)

Colonic MALToma (mucosa-associated lymphoid tissue lymphoma) has not been well investigated compared to stomach MALToma which is related to Helicobacter pylori infection. We report the uncommon case of MALToma in the cecum initially identified as submucosal tumor, successfully treated by laparoscopy-assisted resection with systemic lymphadectomy. As the metastatic ability and sensitivity against chemotherapy of colonic MALToma is not known, temporally, this treatment seems to be the best choice.
Functional morphology of the auditory periphery of humans, common chimpanzees and bonobos and evolution of human auditory capacities (2020)

Author: Stoessel, Alexander et al.; Genre: Meeting Abstract; Issued: 2020-03; Title: Functional morphology of the auditory periphery of humans, common chimpanzees and bonobos and evolution of human auditory capacities
On average throughput and alphabet size in network coding (2005)

We analyze a special class of configurations with h sources and N receivers to demonstrate the throughput benefits of network coding and deterministic code design. We show that the throughput benefits network coding offers can increase proportionally to radicN, with respect to the average as well as the minimum throughput. For this class of configurations we also show that there exists a deterministic coding scheme that realizes these benefits using a binary alphabet whereas randomized coding may require an exponentially large alphabet size
Chronic sympathetic stress during gestation delays puberty and follicular development of female offspring (2014)

Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)
Quantitative localization of angiotensin II receptor subtypes in spontaneously hypertensive rats. (1994)

Angiotensin II (Ang II) receptors were labelled by in vitro autoradiography using 125I-[Sar1,Ile8]Ang II as a ligand in the kidney, adrenal gland, thoracic aorta, and hindbrain of adult spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). Ang II receptors were differentiated into subtypes by susceptibility to subtype 1 (AT1) and subtype 2 (AT2) antagonists. In both rat strains, the adrenal cortex contained predominantly AT1 receptors, while AT2 receptors predominated in the adrenal medulla. The kidney contained exclusively AT1 receptors in glomeruli, proximal tubules, and the outer medulla. AT1 receptors were predominant in the thoracic aorta. The nucleus of the solitary tract (NTS), dorsal motor nucleus of the vagus (DM10), area postrema, and spinal trigeminal nucleus (Sp5) contained exclusively AT1 receptors, whereas the nucleus of the inferior olive contained AT2 receptors predominantly. Significant differences in receptor density were observed between SHR and WKY. The adrenal cortex, renal outer medulla, NTS, DM10, and Sp5 displayed higher AT1 receptor density in SHR than in WKY. These results indicate that expression of AT1 receptors is regulated differently in important targets of Ang II in SHR, and suggest that altered regulation of AT1 receptor expression may be relevant to the pathogenesis of hypertension in SHR.
Influence of force fields on the selective diffusion ofpara-xylene overortho-xylene in 10-ring zeolites (2015)

A molecular dynamics study of diffusion of p-xylene and o-xylene has been performed over three different pure silica 10-ring zeolites, MFI, SFG and TUN. The shape selective properties of the frameworks of these three materials have been tested using four different types of force fields commonly used based on united atom, rigid-ion and core-shell approximations. The performance of each force field is analysed in order to find which force fields can give sufficiently accurate estimations that allow to select appropriate zeolites for selective separation of para/ortho xylene. This performance was found to depend on the quality of the structural properties of the zeolite, in particular the size and shape of the 10 rings which act as bottlenecks for the diffusion. The computational results allow us to define some optimum characteristics for the selective diffusion of p-xylene.
Microfabricated 94 GHz TWT (2014)

Teraphysics Corporation is developing a 94 GHz, 25 W helical traveling wave tube (TWT) with 60% overall efficiency. The TWT includes several innovations including a reinvented helix geometry and fabrication that is compatible with lithographic, microfabrication techniques; a novel mechanical design where the electron gun, circuit and collector are fabricated simultaneously for alignment within two microns; and a novel, compact, periodic permanent magnet focusing configuration. The result is a compact device approximately 2.6” long, 1.9” in diameter, with weight of 1 lb, which will serve as Teraphysics' platform for future mm-wave and THz devices.
Analyzing and Boosting the Performance of Power-Line Communication Networks (2014)

Power-line communications are employed in home networking to provide easy and high-throughput connectivity. IEEE 1901, the MAC protocol for power-line networks, employs a CSMA/CA protocol similar to that of 802.11, but is substantially more complex, which probably explains why little is known about its performance. One of the key differences between the two protocols is that whereas 802.11 only reacts upon collisions, 1901 also reacts upon several consecutive transmissions and thus can potentially achieve better performance by avoiding unnecessary collisions.
Structure and Phylogenetic Analysis of an Endogenous Retrovirus Inserted into the Human Growth Factor Gene Pleiotrophin (1998)

A human endogenous retrovirus-like element (HERV), flanked by long terminal repeats of 502 and 495 nucleotides is inserted into the human pleiotrophin (PTN) gene upstream of the open reading frame. Based on its Glu-tRNA primer binding site specificity and the location within the PTN gene, we named this element HERV-E.PTN. HERV-E.PTN appears to be a recombined viral element based on its high homology (70 to 86%) in distinct areas to members of two distantly related HERV type C families, HERV-E and retrovirus-like element I (RTVL-I). Furthermore, its pseudogene region is organized from 5' to 3' into gag-, pol-, env-, pol-, env-similar sequences. Interestingly, full-length and partial HERV-E.PTN-homologous sequences were found in the human X chromosome, the human hereditary haemochromatosis region, and the BRCA1 pseudogene. Finally, Southern analyses indicate that the HERV-E.PTN element is present in the PTN gene of humans, chimpanzees, and gorillas but not of rhesus monkeys, suggesting that genomic insertion occurred after the separation of monkeys and apes about 25 million years ago.
What are the Driving Factors Influencing the Size Distribution of Airborne Synthetic Clay Particles Emitted from a Jet Milling Process? (2015)

In the field of workplace air quality, measuring and analyzing the size distribution of airborne particles to identify their sources and apportion their contribution has become widely accepted, however, the driving factors that influence this parameter, particularly for nanoparticles (< 100 nm), have not been thoroughly determined. Identification of driving factors, and in turn, general trends in size distribution of emitted particles would facilitate the prediction of nanoparticles’ emission behavior and significantly contribute to their exposure assessment. In this study, a comprehensive analysis of the particle number size distribution data, with a particular focus on the ultrafine size range of synthetic clay particles emitted from a jet milling machine was conducted using the multi-lognormal fitting method. The results showed relatively high contribution of nanoparticles to the emissions in many of the tested cases, and also, that both surface treatment and feed rate of the machine are significant factors influencing the size distribution of the emitted particles of this size. In particular, applying surface treatments and increasing the machine feed rate have the similar effect of reducing the size of the particles, however, no general trend was found in variations of size distribution across different surface treatments and feed rates. The findings of our study demonstrate that for this process and other activities, where no general trend is found in the size distribution of the emitted airborne particles due to dissimilar effects of the driving factors, each case must be treated separately in terms of workplace exposure assessment and regulations.
Distributed Localization: A Linear Theory (2018)

Fifth-generation (5G) networks providing much higher bandwidth and faster data rates will allow connecting vast number of stationary and mobile devices, sensors, agents, users, machines, and vehicles, supporting Internet-of-Things (IoT), real-time dynamic networks of mobile things. Positioning and location awareness will become increasingly important, enabling deployment of new services and contributing to significantly improving the overall performance of the 5G system. Many of the currently talked about solutions to positioning in 5G are centralized, mostly requiring direct communication to the access nodes (or anchors, i.e., nodes with known locations), which in turn requires a high density of anchors. But such centralized positioning solutions may become unwieldy as the number of users and devices continues to grow without limit in sight. As an alternative to the centralized solutions, this paper discusses distributed localization in a 5G-enabled IoT environment where many low power devices, users, or agents are to locate themselves without a direct access to anchors. Even though positioning is essentially a nonlinear problem (solving circle equations by trilateration or triangulation), we discuss a cooperative linear distributed iterative solution with only local measurements, local communication, and local computation needed at each agent. Linearity is obtained by reparametrization of the agent location through barycentric coordinate representations based on local neighborhood geometry that may be computed in terms of certain Cayley-Menger determinants involving relative local inter-agent distance measurements. After a brief introduction to the localization problem, and other available distributed solutions primarily based on directly addressing the nonlinear formulation, we present the distributed linear solution for stationary agent networks and study its convergence, its robustness to noise, and extensions to mobile scenarios, in which agents, users, and (possibly) anchors are dynamic.
National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry as a standard for comparison of new devices. When should we use it, and what should we compare? (1991)

Percutaneous Transluminal Coronary Angioplasty (PTCA) Registry is a con- tinuation of the registry originally established for studying the safety and efficacy of PTCA when it first became available for nonsurgical coronary revascu- larization. The 1979-1981 registry consisted of the consecutive cases performed by the pioneers in the field. To study long-term efficacy, the registry was extended to include a minimum 5-year follow-up. During these 5 years, there were important improvements in dilatation equipment, which had a major impact on case selection and outcome. Documenta- tion of this rapid technological improvement was accomplished by the same investigators who entered a new series of consecutive cases in the registry between August 1985 and May 1986. The multicenter nature of the data base, the excellence of the coop-
Light Energy Extraction From the Minor Surface Arc of an Electrically Pumped Elliptical Microcavity Laser (2009)

In this paper, the efficiency of extracting light energy from the minor surface arc of the elliptical microcavity laser is investigated for the first time using the dynamic thermal electron quantum medium finite-difference time-domain model. Light energy is extracted from the minor surface arc of the elliptical microcavity to a perpendicular waveguide. It is deduced from the field distribution that extraction efficiency of the TM polarization is higher due to wider transverse field profile. Optimum light energy is extracted when the waveguide is 0.342 ¿m away from the edge of the elliptical minor arc. Higher extraction efficiency is also obtained when the waveguide index is lower than the microcavity index. It is believed that this method of extracting light energy allows for smaller device size with higher power output for building photonic integrated circuit.
Validation of Radiolabeling of Drug Formulations for Aerosol Deposition Assessment of Orally Inhaled Products (2012)

Radiolabeling of inhaler formulations for imaging studies is an indirect method of determining lung deposition and regional distribution of drug in human subjects. Hence, ensuring that the radiotracer and drug exhibit similar aerodynamic characteristics when aerosolized, and that addition of the radiotracer has not significantly altered the characteristics of the formulation, are critical steps in the development of a radiolabeling method. The validation phase should occur during development of the radiolabeling method, prior to commencement of in vivo studies. The validation process involves characterization of the aerodynamic particle size distribution (APSD) of drug in the reference formulation, and of both drug and radiotracer in the radiolabeled formulation, using multistage cascade impaction. We propose the adoption of acceptance criteria similar to those recommended by the EMA and ISAM/IPAC-RS for determination of therapeutic equivalence of orally inhaled products: (a) if only total lung deposition is being quantified, the fine particle fraction ratio of both radiolabeled drug and radiotracer to that of the reference drug should fall between 0.85 and 1.18, and (b) if regional lung deposition (e.g., outer and inner lung regions) is to be quantified, the ratio of both radiolabeled drug and radiotracer to reference drug on each impactor stage or group of stages should fall between 0.85 and 1.18. If impactor stages are grouped together, at least four separate groups should be provided. In addition, while conducting in vivo studies, measurement of the APSD of the inhaler used on each study day is recommended to check its suitability for use in man.
Total Chemical Synthesis of the Enzyme Sortase AΔN59 with Full Catalytic Activity (2014)

The enzyme sortase A is a ligase which catalyzes transpeptidation reactions.1, 2 Surface proteins, including virulence factors, that have a C terminal recognition sequence are attached to Gly5 on the peptidoglycan of bacterial cell walls by sortase A.1 The enzyme is an important anti-virulence and anti-infective drug target for resistant strains of Gram-positive bacteria.2 In addition, because sortase A enables the splicing of polypeptide chains, the transpeptidation reaction catalyzed by sortase A is a potentially valuable tool for protein science.3 Here we describe the total chemical synthesis of enzymatically active sortase A. The target 148 residue polypeptide chain of sortase AΔN59 was synthesized by the convergent chemical ligation of four unprotected synthetic peptide segments. The folded protein molecule was isolated by size-exclusion chromatography and had full enzymatic activity in a transpeptidation assay. Total synthesis of sortase A will enable more sophisticated engineering of this important enzyme molecule.