gebhart/patrepeval huggingface dataset:
Novel Self-Assembly Process Using Magnetically Aligned $z$-Axis Anisotropic Conductive Adhesive for High-Density Vertical Interconnection (2012)

In this paper, a novel self-assembly packaging approach using a magnetically aligned <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">z</i> -axis anisotropic conductive adhesive (ACA) is introduced, enhancing the quality of interconnects and reducing packaging cost in fine-pitch electronic circuitry. This self-assembly process creates selectively agglomerated vertical columns on I/O pads and is first demonstrated using the magnetization interaction properties between ferromagnetic conductive particles and I/O pads in the presence of an external magnetic field. Experimentally, this packaging process is verified to be particularly beneficial in improving the environmental reliability of the self-aligned material. At 133 × 133-μm pad size, the resistance of the created interconnects only varies by 2.45 Ω over a 160°C temperature range. In addition, the breakdown current of the self-assembly <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">z</i> -axis ACA was measured to be 2.0 A at 1.3 V. Furthermore, this self-assembly process was demonstrated to still work at the extremely small pad size of 12×19-μm. Finally, through analysis of the design parameters of this self-assembly process, properties of the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">z</i> -axis ACA material and I/O pad structure were suggested to create vertical interconnects for small pads of size in the order of 10 μm.
Personalized Job Recommendation System at LinkedIn (2017)

Online professional social networks such as LinkedIn play a key role in helping job seekers find right career opportunities and job providers reach out to potential candidates. LinkedIn's job ecosystem has been designed to serve as a marketplace for efficient matching between potential candidates and job postings, and to provide tools to connect job seekers and job providers. LinkedIn's job recommendations product is a crucial mechanism to help achieve these goals, wherein personalized sets of recommended job postings are presented for members based on the structured, context data present in their profiles.
Abstract B061: CD81: A new target for therapy of B cell lymphoma (2016)

Abstract CD81 belongs to an evolutionary conserved family of proteins named tetraspanins and it was originally described as a B cell target. Tetraspanins associate in multi-molecular complexes in tetraspanin-enriched microdomains (TEMS). Indeed, in B cells CD81 associates with CD19 and CD21, and together function as co-receptor to lower the cell activation threshold initiated by the BCR. Recently, we have demonstrated the importance of CD81 in tumor growth and metastasis of solid tumors1. However, the role of CD81 in B cell malignancies has not been explored. Previously, we have shown that anti-CD81 antibodies had anti-proliferative effects on human B cell lymphoma cell lines in vitro2. Here we tested the therapeutic effect of a mouse anti-human CD81 antibody in vivo against Raji and SUP-B8 B cell lymphomas using a xenograft model in SCID mice. Our studies demonstrated that our anti-CD81 antibody had therapeutic effect comparable to rituximab. Moreover, we found ADCC as one of the mechanism of action. Furthermore, to enhance the anti-CD81-mediated ADCC we engineered chimeric antibodies containing human IgG1ADCC-HIGH and human IgG4 ADCC-LOW Fc constant regions. Indeed, the chimeric human IgG1 anti-CD81 mAb showed a remarkable increase in NK cell-mediated ADCC compared to Rituximab in vitro. These results suggest that CD81 can be a potential therapeutic target on B cell lymphomas by virtue of both its direct cytotoxic effect and as a mediator of ADCC. The Human IgG1 version is being developed as a therapeutic candidate. 1. Vences-Catalan, F., et al. Cancer Res 75, 4517-4526 (2015). 2. Oren, R., Takahashi, S., Doss, C., Levy, R. &amp; Levy, S. Mol Cell Biol 10, 4007-4015 (1990). Citation Format: Felipe Vences-Catalán, Chiung-Chi Kuo, Ranjani Rajapaksa, Ronald Levy, Shoshana Levy. CD81: A new target for therapy of B cell lymphoma [abstract]. In: Proceedings of the Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; 2016 Sept 25-28; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(11 Suppl):Abstract nr B061.
Limited Reliability of the Spot Urine Protein/Creatinine Ratio in the Longitudinal Evaluation of Patients With Lupus Nephritis (2018)

The spot PCR should not be used for management of LN, and perhaps, other glomerulopathies.
Circular polarized second harmonic generation in single-layered gold saw-tooth structures (2014)

We report on the study of circular polarized second harmonic generation of single-layered gold sawtooth gratings consisting of И and N basic unit incident by left hand and right hand circular polarized light. The result shows that the chiral properties of the structure lead to the chiral nonlinear optical properties.
Abstract B38: Epigenetic effects of viral proteins on global levels of 5-hydroxymethylcytosine in HBV- and HCV-associated hepatocellular carcinoma in mice (2013)

Abstract Hepatitis B virus (HBV) and hepatitis C virus (HCV) have both distinct and shared pathways to mediate development of virus-associated hepatocellular carcinoma (HCC). It has been postulated that viral encoded proteins such as HCV polyprotein or HBV X protein (HBx) induce epigenetic changes that can lead to HCC during chronic infection. 5-Hydroxymethylcytosine (5hmC) is a recently identified cytosine variant and an intermediate in enzyme-catalyzed active DNA demethylation. 5hmC is also considered a stable epigenetic mark during embryo development and tumorigenesis. Herein, we developed a liquid chromatography-mass spectrometry (LC-MS) based approach to assess global genomic 5hmC levels in tissues using several transgenic (Tg) mouse models to determine epigenetic changes induced by HBV and HCV viral proteins and role in pathogenesis of HCC. A 2-to 3-fold reduction in genomic 5hmC was observed in liver samples from both Mdr2-knockout (Mdr2-KO) mice (a model of chronic inflammation-mediated HCC) and Mdr2-KO/HCV-Tg mice (a model carrying Mdr2-KO and HCV polyprotein). Interestingly, a similar fold reduction in 5hmC was detected in (Mdr2+/-)/HCV-Tg mice, which express HCV polyprotein, but do not develop HCC. In parallel, 5hmC levels were assessed in HBx-Tg mice with high-frequency of HCC. However, reduction of 5hmC was not detectable in liver samples from HBx-Tg mice as late as 14 months of age. These results suggest that HCV polyprotein may accelerate inflammation-associated hepato-carcinogenesis in the Mdr2-KO/HCV-Tg mice. Therefore, we speculate that the HCV proteins may directly induce deconstruction of genomic 5hmC to promote HCC development. In contrast, our results in HBx-Tg mice suggest that HBx may employ a different epigenetic mechanism on 5hmC from that of HCV polyprotein. Notably, a significant change in genomic 5hmC was observed early at the pre-cancerous stages of HCC development in Mdr2-KO mice. This finding implies that, during chronic inflammation, a precipitous drop in 5hmC emerges prior to tumor formation. Therefore, 5hmC may provide an important diagnostic marker for early detection of HCC in persons with HCV chronic infection. Citation Format: Yong Jiang, Ting Nie, James Kohler, Leda Bassit, Daniel Goldenberg, Mark Feitelson, Raymond F. Schinazi. Epigenetic effects of viral proteins on global levels of 5-hydroxymethylcytosine in HBV- and HCV-associated hepatocellular carcinoma in mice. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Jun 19-22, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2013;73(13 Suppl):Abstract nr B38.
GridNews: A distributed automatic Greek broadcast transcription system (2009)

In this paper, a distributed system storing and retrieving broadcast news data recorded from the Greek television is presented. These multimodal data are processed in a grid computational environment interconnecting distributed data storage and processing subsystems. The innovative element of this system is the implementation of the signal processing algorithms in this grid environment, offering additional flexibility and computational power. Among the developed signal processing modules are: the Segmentor, cutting up the original videos into shorter ones, the classifier, recognizing whether these short videos contain speech or not, the Greek large-vocabulary speech recognizer, transcribing speech into written text, and finally the text search engine and the video retriever. All the processed data are stored and retrieved in geographically distributed storage elements. A user-friendly, Web-based interface is developed, facilitating the transparent import and storage of new multimodal data, their off-line processing and finally, their search and retrieval.
New Recoverable Poly(ethylene glycol)‐Supported C1‐Diamino‐oligothiophene Ligands for Palladium‐Promoted Asymmetric Allylic Alkylation (AAA) Reactions. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
γ-GLUTAMYLTRANSFERASE (1987)

gamma-Glutamyltransferase (EC 2.3.2.2; gamma-GT) may be important in the transport of amino acids or peptides across the blood-brain barrier. Gamma-GT activities were the same in cortical samples from Alzheimer and age-matched control brains, and there was no correlation between gamma-GT and choline acetyltransferase (ChAT) or acetylcholinesterase (AChE) levels, both of which were significantly reduced in the Alzheimer samples. ChAT and AChE activities were significantly correlated in both groups. ChAT showed a negative correlation with age in the controls and a positive correlation in the Alzheimer group. The opposite was true for gamma-GT, although the correlations were of low significance. The results do not lend any support to the hypothesis of a defect in the blood-brain barrier in Alzheimer disease.
Synthesis and Antiviral Activity of Novel Acyclic Nucleoside Analogues of 5-(1-Azido-2-haloethyl)uracils (2001)

We present the discovery of a novel category of 5-substituted acyclic pyrimidine nucleosides as potent antiviral agents. A series of 1-[(2-hydroxyethoxy)methyl] (5-7), 1-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl] (8-10), and 1-[4-hydroxy-3-(hydroxymethyl)-1-butyl] (11-13) derivatives of 5-(1-azido-2-haloethyl)uracil were synthesized and evaluated for their biological activity in cell culture. 1-[4-Hydroxy-3-(hydroxymethyl)-1-butyl]-5-(1-azido-2-chloroethyl)uracil (12) was the most effective antiviral agent in the in vitro assays against DHBV (EC(50) = 0.31-1.55 microM) and HCMV (EC(50) = 3.1 microM). None of the compounds investigated showed any detectable toxicity to several stationary and proliferating host cells.
Gentamicin release from two‐solution and powder–liquid poly(methyl methacrylate)‐based bone cements by using novel pH method (2004)

The release of gentamicin as a function of time was measured for Palacos and two-solution bone cements by using a novel pH technique. The pH of an aqueous solution of gentamicin is a function of the gentamicin concentration and it decreases linearly over concentrations of 0.0-0.1 wt %. Therefore, a new, direct, and inexpensive in vitro technique was developed based on continuous readings of the pH in phosphate-buffered saline (PBS) at 37 degrees C to determine the release kinetics of gentamicin from poly(methyl methacrylate) (PMMA)-based bone cement. In addition, this method was used to compare the release profiles of Palacos R-40 bone cement with a two-solution bone cement developed in our laboratory and loaded with two different concentrations of gentamicin sulfate. Finally, the pH-based method was used to track the elution of gentamicin in both mixed and static conditions to determine the effect of mixing on the diffusion of gentamicin out of the cement. It was found that Palacos R-40 released 4.95 +/- 0.22 wt % of its gentamicin after 24 h in PBS solution. This data compares favorably with previously reported values of gentamicin elution from Palacos R-40, which ranged from 3 to 8 wt % of the total amount of incorporated gentamicin, depending on the size and the surface area of the samples. The results show that Palacos samples released 4.84 +/- 0.27 mg after 24 h, a two-solution cement loaded with an equivalent concentration of gentamicin sulfate released 3.81 +/- 0.52 mg, and two-solution cement loaded with twice the concentration of Palacos released 5.53 +/- 0.26 mg of gentamicin. A higher percentage of release was recorded from Palacos than from the two-solution bone cement, and the effect of PBS mixing conditions on the release kinetics was only significant in the early stages of release and not at 24 h. It was concluded that monitoring the pH is an effective technique to measure gentamicin release from PMMA-based bone cements in PBS solution.
Spectral vs. spectro-temporal features for acoustic event detection (2011)

Automatic detection of different types of acoustic events is an interesting problem in soundtrack processing. Typical approaches to the problem use short-term spectral features to describe the audio signal, with additional modeling on top to take temporal context into account. We propose an approach to detecting and modeling acoustic events that directly describes temporal context, using convolutive non-negative matrix factorization (NMF). NMF is useful for finding parts-based decompositions of data; here it is used to discover a set of spectro-temporal patch bases that best describe the data, with the patches corresponding to event-like structures. We derive features from the activations of these patch bases, and perform event detection on a database consisting of 16 classes of meeting-room acoustic events. We compare our approach with a baseline using standard short-term mel frequency cepstal coefficient (MFCC) features. We demonstrate that the event-based system is more robust in the presence of added noise than the MFCC-based system, and that a combination of the two systems performs even better than either individually.
Constitutive modelling of PMMA-based bone cement: a functional model of viscoelasticity and its approximation for time domain investigations (2008)

To represent the mechanical behaviour of polyethylmethacrylate-based bone cement, a constitutive approach of finite linear viscoelasticity is formulated and identified. Motivated by the experimental data of storage and loss modulus, the model is based on a three-dimensional functional in integral representation. In the investigated frequency range, the master curve of the loss modulus is constant and that of the storage modulus increases linearly with the logarithm of the frequency. This behaviour corresponds to a viscoelastic fluid, and can be described by a continuous relaxation spectrum. For numerical simulations which are planned in future, the constitutive functional is approximated by a discrete spectrum. To this end, an earlier-developed method to approximate continuous relaxation spectra in limited time or frequency ranges by discrete ones is applied.
Robust sensorless control of grid connected converters with LCL line filters using frequency adaptive observers as AC voltage estimators (2016)

This paper presents robust control of grid connected voltage source converters (VSC) with LCL line filter without grid voltage sensors, measuring only converter inductor currents and DC link voltage. As grid impedance and step-down transformer inductance values are usually not known, proposed control algorithm relies only on converter side inductor value for control parameter, making it robust against grid variations. Proposed method uses frequency adaptive observers as filter capacitor voltage estimators, which enables the use of well-known highly dynamic performing voltage oriented control (VOC). Two versions of the frequency adaptive observers are presented, one in synchronous frame and one in stationary frame. Theoretical results are verified in simulation environment and experimentally.
A Genome-Wide Search Identifies Potential New Susceptibility Loci for Crohnʼs Disease (1999)

Chronic inflammatory bowel disease (IBD) presents as two major clinical forms, Crohn's disease (CD) and ulcerative colitis (UC). Genetic epidemiological studies and animal models suggest that inherited factors play significant roles in the susceptibility to both forms of IBD. From four genome-wide scans, putative susceptibility loci on chromosome 16 (IBD1 for CD), and on chromosomes 1, 3, 4, 6, 7, 10, and 12 for IBD, have been identified. Several other groups, including ours, have confirmed linkage to the loci on chromosomes 12 and 16. The aim of this study is to identify other potential susceptibility loci for CD with a genome-wide search approach. In our sample of 222 individuals from 46 families (20 Jewish and 26 non-Jewish), with a total of 65 sibpairs diagnosed with CD, we observed a novel locus with suggestive linkage [multipoint logarithm of the odds score (Mlod) > 2] at chromosome 14q11.2 (Mlod = 2.8, p = 0.0002). In addition, suggestive linkage was observed in our Jewish families at chromosome 17q21-q23 (Mlod = 2.1, p = 0.01) and chromosome 5q33-q35 (Mlod = 2.2, p = 0.0003). The syntenic regions of the latter locus are mapped within two putative loci on mouse chromosomes 11 and 18, which were identified in a mouse IBD model induced by dextran sulfate sodium (29). Our preliminary results provide potential evidence for several susceptibility loci contributing to the risk of CD. The observation of man-mouse synteny may accelerate the identification of CD susceptibility gene(s) on human chromosome 5.
ChemInform Abstract: REACTION OF 1,2‐ AND 1,3‐DICARBONYL COMPOUNDS WITH DIMETHYL β‐KETOGLUTARATE. I. SYNTHESIS OF METHYL 5,6,7,8‐TETRAHYDRO‐5‐OXOCOUMARIN‐Δ 4(3H),α‐ACETATE (1976)

Abstract Die Kondensation zwischen dem β‐Keto‐glutarsäuredimethylester (I) und 1,3‐Cyclohexandion (II) liefert über die Zwischenstufen (III) und (IV) das hydrierte Cumarin (V).
Enhancing the Oxygen Plasma Resistance of Low-k Methylsilsesquioxane by H2 Plasma Treatment (1999)

The organic silsesquioxane, methylsilsesquioxane (MSQ), has a low dielectric constant because of its low film density compared to thermal oxide. However, the quality of the MSQ film is degraded by the damage caused by oxygen plasma and hygroscopic behavior during photoresist stripping. In this work, we have studied the ability of H 2 plasma treatment to improve the quality of MSQ. The leakage current of MSQ decreases as the H 2 plasma treatment time is increased. The dielectric constant of treated samples remains constant (∼2.7). In addition, the thermal stability of MSQ film is significantly promoted. The H 2 plasma treatment can provide additional hydrogen to passivate the inner structure of porous MSQ film, and reduce the probability of moisture uptake. Therefore, H 2 plasma treatment can improve the quality of low- k MSQ film and reduce the issue of photoresist stripping in the integrated process.
Ultra-long term stability of single units using chronically implanted multielectrode arrays (2014)

Recordings from chronically implanted multielectrode arrays have become prevalent in both neuroscience and neural engineering experiments. To date, however, the extent to which populations of single-units remain stable over long periods of time has not been well characterized. In this study, neural activity was recorded from a Utah multielectrode array implanted in the primary motor cortex of a rhesus macaque during 18 recording sessions spanning nine months. We found that 67% of the units were stable through the first 15 days, 31% of units were stable through 47 days, 21% of units were stable through 106 days, and 8% of units were stable over 9 months. Thus not only were units stable over a timescale of several months, but units stable over 2 months were more likely to remain stable in the next 2 months.
On-Demand Single Photon Emission based on Quantum Feedback Control of a Microcavity (2016)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Heuck, M. Pant, and D. Englund, "On-Demand Single Photon Emission based on Quantum Feedback Control of a Microcavity," in Conference on Lasers and Electro-Optics, OSA Technical Digest (online) (Optica Publishing Group, 2016), paper FTu4C.7. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Shining a Light on Photoresponsive Type III Porous Liquids (2022)

Porous materials are the subject of extensive research because of potential applications in areas such as gas adsorption and molecular separations. Until recently, most porous materials were solids, but there is now an emerging class of materials known as porous liquids. The incorporation of intrinsic porosity or cavities in a liquid can result in free-flowing materials that are capable of gas uptakes that are significantly higher than conventional non-porous liquids. A handful of porous liquids have also been investigated for gas separations. Until now, the release of gas from porous liquids has relied on molecular displacement (e.g., by adding small solvent molecules), pressure or temperature swings, or sonication. Here, we explore a new method of gas release that involves photoisomerisable porous liquids comprising a photoresponsive MOF dispersed in an ionic liquid. This results in the selective uptake of CO2 over CH4, and allows gas release to be controlled by using UV light.
Coriolis and centrifugal forces drive haltere deformations and influence spike timing (2019)

The halteres of flies are mechanosensory organs that serve a crucial role in the control of agile flight, providing sensory input for rapid course corrections to perturbations. Derived from hind wings, halteres are actively flapped and are thus subject to a variety of inertial forces as the fly undergoes complex flight trajectories. Previous analyses of halteres modelled them as a point mass, showing that Coriolis forces lead to subtle deflections orthogonal to the plane of flapping. By design, these models could not consider the effects of force gradients associated with a mass distribution, nor could they reveal three-dimensional spatio-temporal patterns of strain that result from those forces. In addition, diversity in the geometry of halteres, such as shape and asymmetries, could not be simply modelled with a point mass on a massless rod. To study the effects of mass distributions and asymmetries, we examine the haltere subject to both flapping and body rotations using three-dimensional finite-element simulations. We focus on a set of simplified geometries, in which we vary the stalk and bulb shape. We find that haltere mass distribution gives rise to two unreported deformation modes: (i) halteres twist with a magnitude that strongly depends on stalk and bulb geometry and (ii) halteres with an asymmetric mass distribution experience out-of-plane bending due to centrifugal forces, independent of body rotation. Since local strains at the base of the haltere drive deformations of mechanosensory neurons, we combined measured neural encoding mechanisms with our structural analyses to predict the spatial and temporal patterns of neural activity. This activity depends on both the flapping and rotation dynamics, and we show how the timing of neural activity is a viable mechanism for rotation-rate encoding. Our results provide new insights in haltere dynamics and show the viability for timing-based encoding of fly body rotations by halteres.
Cytochrome P450?inducing antiepileptics increase the clearance of vincristine in patients with brain tumors (1999)

Drugs that induce CYP3A4 can increase the elimination of vincristine. Further studies are needed to determine whether the increased clearance of vincristine by carbamazepine or phenytoin decreases the efficacy of vincristine.