gebhart/patrepeval huggingface dataset:
Evaluation of a Diet Containing Probiotics and Zinc for the Treatment of Mild Diarrheal Illness in Children Younger Than One Year of Age (2005)

In our series, the feeding of a cereal containing Streptococcus thermophilus, Bifidobacterium lactis, Lactobacillus acidophilus and zinc, reduced the severity and duration of acute gastroenteritis in young children. However, whether this combination is better than either the addition of probiotics or zinc alone is yet to be determined.
Hedge Your Bets: Optimizing Long-term Cloud Costs by Mixing VM Purchasing Options (2020)

Cloud platforms offer the same VMs under many purchasing options that specify different costs and time commitments, such as on-demand, reserved, sustained-use, scheduled reserve, transient, and spot block. In general, the stronger the commitment, i.e., longer and less flexible, the lower the price. However, longer and less flexible time commitments can increase cloud costs for users if future workloads cannot utilize the VMs they committed to buying. Large cloud customers often find it challenging to choose the right mix of purchasing options to reduce their long-term costs, while retaining the ability to adjust capacity up and down in response to workload variations.To address the problem, we design policies to optimize long-term cloud costs by selecting a mix of VM purchasing options based on short- and long-term expectations of workload utilization. We consider a batch trace spanning 4 years from a large shared cluster for a major state University system that includes 14k cores and 60 million job submissions, and evaluate how these jobs could be judiciously executed using cloud servers using our approach. Our results show that our policies incur a cost within 41% of an optimistic optimal offline approach, and 50% less than solely using on-demand VMs.
Learning Chance Probability Functions for Shape Retrieval or Classification (2005)

Several example-based systems for shape retrieval and shape classification directly match input shapes to stored shapes, without using class membership information to perform the matching. We propose a method for improving the accuracy of this type of system. First, the system learns a set of chance probability functions (CPFs). The CPFs estimate the probabilities of obtaining a query shape with particular distances from each training example by chance. The learned CPFs are used at runtime to rapidly estimate the chance probabilities of the observed distances between the actual query shape and the database shapes. These estimated probabilities are then used as a dissimilarity measure for shape retrieval and/or nearest-neighbor classification. The CPF learning method is parameter-free. Experimental evaluation demonstrates that: (1) chance probabilities yield higher accuracy than Euclidean distances; (2) the learned CPFs support fast matching; and (3) the CPF-based system outperforms prior systems on a standard benchmark test of retrieval accuracy.
Sex-based Differences in Common Sports Injuries (2018)

The patient's sex plays an important role in mediating the risk for, and experience of, disease. Injuries of the musculoskeletal system are no exception to this phenomenon. Increasing evidence shows that the incidence, clinical presentation, and treatment outcomes for male and female patients with common sports injuries may vary widely. Stress fracture, which is associated with the female athlete triad, is a sports injury with known sex-based differences. Other common sports-related injuries may also have distinct sex-based differences. Understanding these differences is important to optimize each patient's musculoskeletal care.
Size-Dependent Oxidation of Monodisperse Silicon Nanocrystals with Allylphenylsulfide Surfaces (2014)

The synthesis and characterization of size-separated silicon nanocrystals functionalized with a heteroatom-substituted organic capping group, allylphenylsulfide, via photochemical hydrosilylation are described for the first time. These silicon nanocrystals form colloidally stable and highly photoluminescent dispersions in non-polar organic solvents with an absolute quantum yield as high as 52% which is 20% above that of the allylbenzene analogue. Solutions of the size-separated fractions are characterized over time to monitor the effect of aging in air by following the change of their photoluminescence and absolute quantum yields, supplemented by transmission electron microscopy.
Development And Implementation Of A Robot Based Freshman Engineering Course (2020)

We describe the background and rationale for a new freshman course incorporating construction and testing of a small mobile robot. The custom robot kit is assembled in stages as the novice students learn basic electrical principles, the terminal characteristics of circuit components, and the basic practical skills necessary to build and test a printed circuit board. In this paper we explain the risks and difficulties overcome during the course development, the features and capabilities of the custom robot kits, and the assessment results for our first group of 90 students during the Fall 2004 semester.
The Utility of NKX2.2 and TLE1 Immunohistochemistry in the Differentiation of Ewing Sarcoma and Synovial Sarcoma (2017)

Although molecular testing can definitively distinguish Ewing sarcoma (EWS) from synovial sarcoma (SS) it is frequently desirable to provide a confident preliminary diagnosis before such analysis can be completed. Recently, the nuclear markers NKX2.2 and TLE1 have been shown to have good sensitivity but imperfect specificity, respectively, for EWS and SS. However, the performance of these markers has not been extensively evaluated within this specific differential diagnosis. This study performed NKX2.2, TLE1, and CD99 immunohistochemistry in a group of EWS and SSs confirmed by reverse transcription-polymerase chain reaction to evaluate the utility of these novel markers in this context. NKX2.2 staining was overall 75% sensitive and 91.7% specific for EWS and was never seen in SS. Although the specificity of TLE1 staining was impacted by antibody used, it was at best only 75% specific for SS. However, a lack of reactivity had a 100% negative predictive value against a SS diagnosis. Overall, immunohistochemistry for NKX2.2 and TLE1 can provide a useful first step in helping to distinguish EWS and SS.
Sequence Analysis of the Genome of Carnation (Dianthus caryophyllus L.) (2013)

The whole-genome sequence of carnation (Dianthus caryophyllus L.) cv. ‘Francesco’ was determined using a combination of different new-generation multiplex sequencing platforms. The total length of the non-redundant sequences was 568 887 315 bp, consisting of 45 088 scaffolds, which covered 91% of the 622 Mb carnation genome estimated by k-mer analysis. The N50 values of contigs and scaffolds were 16 644 bp and 60 737 bp, respectively, and the longest scaffold was 1 287 144 bp. The average GC content of the contig sequences was 36%. A total of 1050, 13, 92 and 143 genes for tRNAs, rRNAs, snoRNA and miRNA, respectively, were identified in the assembled genomic sequences. For protein-encoding genes, 43 266 complete and partial gene structures excluding those in transposable elements were deduced. Gene coverage was ∼98%, as deduced from the coverage of the core eukaryotic genes. Intensive characterization of the assigned carnation genes and comparison with those of other plant species revealed characteristic features of the carnation genome. The results of this study will serve as a valuable resource for fundamental and applied research of carnation, especially for breeding new carnation varieties. Further information on the genomic sequences is available at http://carnation.kazusa.or.jp.
Resist pattern inspection for defect reduction in sub-15 nm templates (2020)

An essential element of sub-15 nm nanoimprint lithography is to create fine patterns on a template. However, it is challenging to create sub-15 nm half-pitch patterns on a template by direct drawing with a resist, owing to poor resolution and low sensitivity. We are currently researching the development of sub-15 nm half-pitch patterns by applying self-aligned double patterning on a template. The defect density of the template has not yet reached a high-volume manufacturing level. The aim of our study is to achieve a defect density of less than 1 pcs/cm<sup>2</sup> for sub-15 nm templates. To achieve this, we need to overcome stochastics-induced resist defects. We aim to determine the mechanism of defect formation by observing the details of the defects. We challenged resist-pattern inspections using a grazing-incidence coherent scatterometry microscope, which illuminated an extreme ultraviolet light to the resist pattern and detected the diffraction signal from the pattern. This study was conducted in collaboration with University of Hyogo and Kioxia Corporation. In this paper, we present the results of damage evaluations and resist-pattern inspections.
A New Picture of Ionomer Structure and Dynamics. (2014)

Abstract not provided.
Abstract C180: A novel bispecific platform for potent redirected killing of B-cell lymphoma (2009)

Abstract Despite significant advances in the treatment of B-cell lymphoma, in many cases the disease remains untreatable or displays recurrence after initial response to therapy. The recent clinical success of bi-specific molecules capable of redirecting T-lymphocyte-mediated cytotoxicity (Bi-specific T-cell Engagers, BiTEs) against B-cell lymphoma provides a feasible therapeutic option. We have developed an alternate bi-specific platform of Dual-Affinity Re-Targeting (DART) molecules that is well suited for clinical applications. Compared to BiTEs, which comprise a pair of single-chain Fv domains in a single polypeptide, DARTs contain two separate chains associated into a heterodimeric, covalently linked, ‘diabody’ structure. We show here that DARTs are very stable in vitro and can be built to recruit and retarget different effector cells, including T cells or CD16- (Fc RIII)-positive cells, against B-cell-lineage targets. A CD3xCD19 DART capable of recruiting cytotoxic T cells against CD19-positive targets mediated extremely potent killing of human peripheral blood B lymphocytes or B-cell lymphoma lines in vitro, with an EC50 that compares favorably to that of a BiTE with identical Fv sequences. Redirected killing of Daudi, Raji, or Nalm6 lymphoma lines was observed in the picomolar range using either freshly purified T cells or peripheral blood mononuclear cells (PBMC) as effector populations. In contrast, no killing was observed against a CD19-negative cell line (RPMI-8226) with either resting or stimulated effector populations, indicating a requirement for CD19 engagement for T-cell-mediated killing by the CD3xCD19 DART molecule. Furthermore, a DART constructed with a humanized version of a pan anti-TCR-beta antibody (TCRxCD19 DART) was as efficient against CD19-positive targets as the CD3-based DART. A CD16xCD32B DART was also constructed to redirect CD16-positive NK and/or mononuclear phagocyte effector cells against CD32B-positive B cells, displaying potent killing against Daudi, Raji or RPMI-8226 cells but not against a CD32B-negative cell line (Ramos). Both TCR- and CD16-based DARTs show potent activity in vivo in several mouse models, including autologous B-cell depletion in huCD32B-transgenic mice, tumor reduction in human Raji Burkitt's lymphoma cell xenografts and Raji cell implants in NOD/SCID mice reconstituted with human PBMC. In conclusion, DARTs represent a robust and flexible platform to recruit different cell populations via various cell surface targets for re-directed killing applications against B-cell malignancies. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):C180.
2α,3α-Dihydroxy-7-oxa-6-oxo-B-homo-5α-pregnan-21-oic acid and its derivatives as brassinolide analogues (1987)

The synthesis of compounds VIIIb,c,f,h and their plant growth-promoting activity is reported. These compounds differ from the previously described substances Ia-d by the absence of the 21-methyl group, this structural change resulting in a dramatic decrease in the growth-promoting activity.
ChemInform Abstract: Si—Ge‐Based Oxynitrides: From Molecules to Solids (2010)

Abstract DFT calculations
Importance of Polarization for Dipolar Solutes in Low-Dielectric Media: 1,2-Dichloroethane and Water in Cyclohexane (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImportance of Polarization for Dipolar Solutes in Low-Dielectric Media: 1,2-Dichloroethane and Water in CyclohexaneWilliam L. Jorgensen, Nora A. McDonald, Massimo Selmi, and Paul R. RablenCite this: J. Am. Chem. Soc. 1995, 117, 47, 11809–11810Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ja00152a025https://doi.org/10.1021/ja00152a025research-articleACS PublicationsRequest reuse permissionsArticle Views385Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Hybrid wavelength-division and optical time-division multiplexed multiwavelength mode-locked semiconductor laser (2000)

A multiwavelength laser source composed of a single semiconductor optical amplifier and a commercially available off-the-shelf wavelength-division multiplexed (WDM) filter is constructed and tested under actively mode-locking operation. Five independent mode-locked wavelength channels are generated simultaneously, with a wavelength spacing of 1.6 nm established by the WDM filter. In addition, to demonstrate the potential of this mixed time-frequency, or hybrid WDM-optical time-division multiplexed, signal, we demonstrate a simple parallel-to-serial wavelength conversion to increase the pulse repetition rate of the mode-locked laser by a number of output wavelengths for applications in high-performance optical sampling applications.
CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity (1997)

CD44 is expressed in various isoforms on numerous cell types and tissues during embryogenesis and in the mature organism. CD44 may also be involved in tumor growth. To study the multiple roles of CD44, we abolished expression of all known isoforms of CD44 in mice by targeting exons encoding the invariant N-terminus region of the molecule. Surprisingly, mice were born in Mendelian ratio without any obvious developmental or neurological deficits. Hematological impairment was evidenced by altered tissue distribution of myeloid progenitors with increased levels of colony-forming unit–granulocyte-macrophage (CFU-GM) in bone marrow and reduced numbers of CFU-GM in spleen. Fetal liver colony-forming unit–spleen and granulocyte colony-stimulating factor mobilization assays, together with reduced CFU-GM in peripheral blood, suggested that progenitor egress from bone marrow was defective. In what was either a compensatory response to CD44 deficiency or an immunoregulatory defect, mice also developed exaggerated granuloma responses to Cryotosporidium parvum infection. Finally, tumor studies showed that SV40-transformed CD44-deficient fibroblasts were highly tumorigenic in nude mice, whereas reintroduction of CD44s expression into these fibroblasts resulted in a dramatic inhibition of tumor growth.
Using Wireline Formation-Tester Data for Reservoir Characterization and Connectivity Determination in Ultradeepwater and High-Pressure Wilcox Formation in Gulf of Mexico (2017)

Abstract Deepwater turbidite reservoirs have always presented several reservoir characterization challenges. Determining the complex architecture of the sand bodies, correlating them across multiple wells in the structure, and defining the sedimentological facies to determine the reservoir vertical communication and boundaries are some challenges in these Gulf of Mexico (GOM) turbidites. Other formation-related challenges of turbidite reservoir exploration and development include understanding reservoir rock quality and compartmentalization, as well as the identification of fluids. Deepwater exploration and development require innovative, cost effective evaluation technologies—technologies that help manage ultradeep and high-pressure environments. Having a detailed description of reservoir properties, fluids characterization, and a determination of the reservoir connectivity are crucial for understanding the reservoir and optimizing the field development plan. This study describes the wireline formation tester (WFT) operations performed in a harsh environment [ultradeepwater subsalt formation (&amp;gt; 32,000 ft) and high pressure (&amp;gt; 25,000 psi)] to obtain pressure data, establish gradients, evaluate vertical connectivity using vertical interference tests (VITs), check for compositional variation in different oil columns, and obtain clean formation fluid samples. Downhole fluid analysis was performed to help ensure the quality of formation samples and determine the fluid compositional analysis in real time during pumpout. To obtain high quality fluid samples while minimizing costs, an innovative technology—namely, a focused sampling probe—was used, eliminating the need for long pumpouts. Representative formation fluid samples were captured from three sample depths in approximately two hours per sample depth with minimum oil-based mud (OBM) contamination (&amp;lt; 5%). All the available openhole log data were integrated to understand the reservoir before running the WFT. Optimizing pressure and sampling depths (most representative intervals) can help reduce uncertainty when determining the number of pressure and sample points in the reservoir. Formation mobility, near-wellbore skin damage, reservoir pressure, downhole compositional fluid analysis, and reservoir connectivity were evaluated in a unique and challenging environment. Reservoir connectivity results from formation testing show good alignment with the presence of fractures and other sedimentary features from borehole image data. A similar methodology can be extended to other deepwater turbidite reservoirs in the GOM.
Supplementary Figure 1 from Molecular Imaging of the Efficacy of Heat Shock Protein 90 Inhibitors in Living Subjects (2023)

Supplementary Figure 1 from Molecular Imaging of the Efficacy of Heat Shock Protein 90 Inhibitors in Living Subjects
Genome-Wide Analysis of Heteroduplex DNA in Mismatch Repair–Deficient Yeast Cells Reveals Novel Properties of Meiotic Recombination Pathways (2011)

Meiotic DNA double-strand breaks (DSBs) initiate crossover (CO) recombination, which is necessary for accurate chromosome segregation, but DSBs may also repair as non-crossovers (NCOs). Multiple recombination pathways with specific intermediates are expected to lead to COs and NCOs. We revisited the mechanisms of meiotic DSB repair and the regulation of CO formation, by conducting a genome-wide analysis of strand-transfer intermediates associated with recombination events. We performed this analysis in a SK1 × S288C Saccharomyces cerevisiae hybrid lacking the mismatch repair (MMR) protein Msh2, to allow efficient detection of heteroduplex DNAs (hDNAs). First, we observed that the anti-recombinogenic activity of MMR is responsible for a 20% drop in CO number, suggesting that in MMR-proficient cells some DSBs are repaired using the sister chromatid as a template when polymorphisms are present. Second, we observed that a large fraction of NCOs were associated with trans-hDNA tracts constrained to a single chromatid. This unexpected finding is compatible with dissolution of double Holliday junctions (dHJs) during repair, and it suggests the existence of a novel control point for CO formation at the level of the dHJ intermediate, in addition to the previously described control point before the dHJ formation step. Finally, we observed that COs are associated with complex hDNA patterns, confirming that the canonical double-strand break repair model is not sufficient to explain the formation of most COs. We propose that multiple factors contribute to the complexity of recombination intermediates. These factors include repair of nicks and double-stranded gaps, template switches between non-sister and sister chromatids, and HJ branch migration. Finally, the good correlation between the strand transfer properties observed in the absence of and in the presence of Msh2 suggests that the intermediates detected in the absence of Msh2 reflect normal intermediates.
Prognostic relevance of the mTOR pathway in renal cell carcinoma (2007)

Components of the mTOR pathway are significantly associated with pathological features and survival. Not all RCC tumor types seem to be equally amenable to mTOR targeted therapy. PTEN, pAkt, p27, and pS6 may serve as surrogate parameters for patient selection and predicting prognosis. Patients with a highly activated mTOR pathway should benefit most from this therapy. External validation of our results is recommended.
Successful implementation of a disease-specific survivorship program for men with prostate cancer (PC) and their partners. (2016)

31 Background: Treatment for localized PC can adversely impact the quality of life for the patient (pts) and his partner. Addition of androgen deprivation therapy (ADT) to treat biochemical relapse or metastatic disease can result in further symptoms. We hypothesized that PC pts and partners would benefit from a clinical, educational, research-based approach to care that would focus on their specific needs. Methods: Funding from government agencies and philanthropic sources were used to establish a survivorship program in the urology clinic at the Vancouver Prostate Centre. A multi-disciplinary management team was formed to oversee the program. The Prostate Cancer Supportive Care (PCSC) Program is organized around 5 thematic modules 1) information about PC and primary treatment options (TX), 2) sexual health and intimacy (SH), 3) lifestyle changes in diet and exercise (DE), 4) managing the side effects of ADT, 5) incontinence and pelvic floor physiotherapy (PT). Group educational sessions (ED) are held 1-2 times monthly. Individual clinic appointments with SH and PT clinicians are also available. A program manager, clinic coordinator, and research assistant run PCSC on a day-to-day basis. Results: PCSC was initiated in January 2013. Urologists, nurses, pharmacists, and radiation oncologists referred patients to PCSC. Of 802 pts who enrolled (167 in 2013, 369 in 2014, and 266 in 2015 to date), to receive the quarterly newsletter, 626 (78%) chose to actively participate in at least one module (summarized in table). Feedback from couples, participating clinicians, and allied health personnel has been overwhelmingly positive. In addition, the PCSC population is proving to be a rich source of patients for research projects and training opportunities for young MDs. Conclusions: The results demonstrate that implementation of a disease specific survivorship program is feasible, well received and has other unanticipated benefits. Outcomes research and intervention protocols are in progress to address our hypothesis. [Table: see text]