gebhart/patrepeval huggingface dataset:
Common variants underlying cognitive ability: further evidence for association between the SNAP‐25 gene and cognition using a family‐based study in two independent Dutch cohorts (2007)

The synaptosomal associated protein of 25 kDa (SNAP‐25) gene, located on chromosome 20 p12‐12p11.2 encodes a presynaptic terminal protein. SNAP‐25 is differentially expressed in the brain, and primarily present in the neocortex, hippocampus, anterior thalamic nuclei, substantia nigra and cerebellar granular cells. Recently, a family‐based genetic association was reported between variation in intelligence quotient (IQ) phenotypes and two intronic variants on the SNAP‐25 gene. The present study is a follow‐up association study in two Dutch cohorts of 371 children (mean age 12.4 years) and 391 adults (mean age 36.2 years). It examines the complete genomic region of the SNAP‐25 gene to narrow down the location of causative genetic variant underlying the association. Two new variants in intron 1 (rs363043 and rs353016), close to the two previous reported variants (rs363039 and rs363050) showed association with variation in IQ phenotypes across both cohorts. All four single nucleotide polymorphisms were located in intron 1, within a region of about 13.8 kbp, and are known to affect transcription factor‐binding sites. Contrary to what is expected in monogenic traits, subtle changes are postulated to influence the phenotypic outcome of complex (common) traits. As a result, functional polymorphisms in (non)coding regulatory sequences may affect spatial and temporal regulation of gene expression underlying normal cognitive variation.
Mechanistic link between erectile dysfunction and systemic endothelial dysfunction in type 2 diabetic rats (2016)

Men with type 2 diabetes mellitus (T2DM) and erectile dysfunction (ED) have greater risk of cardiovascular events than T2DM men without ED, suggesting ED as a predictor of cardiovascular events in diabetic men. However, molecular mechanisms underlying endothelial dysfunction in the diabetic penis explaining these clinical observations are not known. We evaluated whether the temporal relationship between ED and endothelial dysfunction in the systemic vasculature in T2DM involves earlier redox imbalance and endothelial nitric oxidase synthase (eNOS) dysfunction in the penis than in the systemic vasculature, such as the carotid artery. Rats were rendered T2DM by high-fat diet for 2 weeks, followed by an injection with low-dose streptozotocin. After 3 weeks, erectile function (intracavernosal pressure) was measured and penes and carotid arteries were collected for molecular analyses of eNOS uncoupling, protein S-glutathionylation, oxidative stress (4-hydroxy-2-nonenal, 4-HNE), protein expression of NADPH oxidase subunit gp91(phox) , endothelium-dependent vasodilation in the carotid artery, and non-adrenergic, non-cholinergic (NANC)-mediated cavernosal relaxation. Erectile response to electrical stimulation of the cavernous nerve and NANC-mediated cavernosal relaxation was decreased (p < 0.05), while relaxation of the carotid artery to acetylcholine was not impaired in T2DM rats. eNOS monomerization, protein expressions of 4-HNE and gp91(phox) , and protein S-glutathionylation, were increased (p < 0.05) in the penis, but not in the carotid artery, of T2DM compared to non-diabetic rats. In conclusion, redox imbalance, increased oxidative stress by NADPH oxidase, and eNOS uncoupling, occur early in T2DM in the penis, but not in the carotid artery. These molecular changes contribute to T2DM ED, while vascular function in the systemic vasculature remains preserved.
Bragg Holograms And Concentrator Optics (1985)

NTS Super-High Efficiency (SHE) Holographic Technology consists of Dichromated Gelatin (DCG) Bragg Reflection Holograms possessing properties that maximum hologram diffraction efficiency (reflection, in good approximation) is close to 99.7% and optical scattering/ absorption losses are below 0.2%. Hence, NTS Reflection Holograms can achieve close to the theoretical limit for several important holographic applications, including dichroic/ polychroic mirrors, high-reflection spectrum-selective filters, spectrum-splitting PV/TPV holoconcentrators, large holographic mirrors for space applications, holographic heads-up displays, holographic fiber couplers, holographic optical elements (HOEs) holographic coders/decoders, holographic window films, holographic chromatic filters, etc. In this paper, we discussed the application of SHE Holographic Technology to concentrator optics including especially solar applications.
Exploration of biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab (2020)

This is the first clinical trial to explore the biomarkers, including potential proteomic markers, most strongly associated with improvement in EASI in patients with moderate-to-severe AD treated with dupilumab for 16 weeks (B-PAD study). A limitation is that we will only enroll Japanese patients.
SINGULAR AND NEAR‐SINGULAR INTEGRALS IN HIGH‐PRECISION DERIVATIVE COMPUTATION (1995)

Accurate numerical differentiation of approximate data by methods based on Green's second identity often involves singular or nearly singular integrals over domains or their boundaries. This paper applies the finite part integration concept to evaluate such integrals and to generate suitable quadrature formulae. The weak singularity involved in first derivatives is removable; the strong singularities encountered in computing higher derivatives can be reduced. To find derivatives on or near the edge of the integration region, special treatment of boundary integrals is required. Values of normal derivative at points on the edge are obtainable by the method described. Example results are given for derivatives of analytically known functions, as well as results from finite element analysis.
The Food and Drug Administration Advisory Committees and Panels: How They Are Applied to the Drug Regulatory Process (2014)

Food and Drug Administration (FDA) advisory panels and committees play a critical role in advising the FDA on the safety and efficacy of medical devices and drugs marketed in the US. Advisory panel recommendations are used by the FDA to make decisions regarding medical products. Currently, the FDA utilizes over 50 advisory panels that serve the three major FDA centers, including the Centers for Biologics, Drugs and Device Products. Members of an advisory panel typically include academicians, clinicians, consumers, patients, and industry representatives. The FDA establishes the schedules for advisory panel meetings on an annual basis and a panel usually meets several times a year for two consecutive days in Washington, DC. Typically, the advisory panel discusses issues highlighted by the FDA and is then asked to vote a response to the questions posed in advance by the FDA. Advisory panel recommendations have a strong influence on FDA's decision to approve a product, as evidenced by the 214 Advisory Panels FDA convened between January 2008 to November 2012, during which advisory panel members voted to approve the product (or use of the product) ∼74% of the time, with FDA ultimately approving the medical product (or use of the product) ∼79% of the time. The ACG membership are encouraged to consider serving the public's interest by participating in an FDA advisory panel utilizing their expertise for the evaluation of a new drug or medical device, and providing advice about whether the product should be sold in the US.
Laparoscopic Nephropexy: Long-Term Follow-Up— Washington University Experience (2000)

Nephropexy can be safely and effectively accomplished laparoscopically, with durable radiographic and clinical resolution of the signs and symptoms.
High-fidelity video and still-image communication based on spectral information: natural vision system and its applications (2006)

In addition to the great advancement of high-resolution and large-screen imaging technology, the issue of color is now receiving considerable attention as another aspect than the image resolution. It is difficult to reproduce the original color of subject in conventional imaging systems, and that obstructs the applications of visual communication systems in telemedicine, electronic commerce, and digital museum. To breakthrough the limitation of conventional RGB 3-primary systems, "Natural Vision" project aims at an innovative video and still-image communication technology with high-fidelity color reproduction capability, based on spectral information. This paper summarizes the results of NV project including the development of multispectral and multiprimary imaging technologies and the experimental investigations on the applications to medicine, digital archives, electronic commerce, and computer graphics.
Normative data for the Montreal Cognitive Assessment (MoCA) in a population-based sample (2012)

Dr
Electron flow through biological molecules: does hole hopping protect proteins from oxidative damage? (2015)

Biological electron transfers often occur between metal-containing cofactors that are separated by very large molecular distances. Employing photosensitizer-modified iron and copper proteins, we have shown that single-step electron tunneling can occur on nanosecond to microsecond timescales at distances between 15 and 20 Å. We also have shown that charge transport can occur over even longer distances by hole hopping (multistep tunneling) through intervening tyrosines and tryptophans. In this perspective, we advance the hypothesis that such hole hopping through Tyr/Trp chains could protect oxygenase, dioxygenase, and peroxidase enzymes from oxidative damage. In support of this view, by examining the structures of P450 (CYP102A) and 2OG-Fe (TauD) enzymes, we have identified candidate Tyr/Trp chains that could transfer holes from uncoupled high-potential intermediates to reductants in contact with protein surface sites.
A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC (2016)

Colorectal cancer (CRC) is a highly heterogeneous disease, for which prognosis has been relegated to clinicopathologic staging for decades. There is a need to stratify subpopulations of CRC on a molecular basis to better predict outcome and assign therapies. Here we report targeted exome-sequencing of 1,321 cancer-related genes on 468 tumour specimens, which identified a subset of 17 genes that best classify CRC, with APC playing a central role in predicting overall survival. APC may assume 0, 1 or 2 truncating mutations, each with a striking differential impact on survival. Tumours lacking any APC mutation carry a worse prognosis than single APC mutation tumours; however, two APC mutation tumours with mutant KRAS and TP53 confer the poorest survival among all the subgroups examined. Our study demonstrates a prognostic role for APC and suggests that sequencing of APC may have clinical utility in the routine staging and potential therapeutic assignment for CRC.
A Function of Lung Surfactant Protein SP-B (1993)

The primary function of lung surfactant is to form monolayers at the alveolar interface capable of lowering the normal surface tension to near zero. To accomplish this process, the surfactant must be capable of maintaining a coherent, tightly packed monolayer that avoids collapse during expiration. The positively charged amino-terminal peptide SP-B1-25 of lung surfactant-specific protein SP-B increases the collapse pressure of an important component of lung surfactant, palmitic acid (PA), to nearly 70 millinewtons per meter. This alteration of the PA isotherms removes the driving force for "squeeze-out" of the fatty acids from the primarily dipalmitoylphosphatidylcholine monolayers of lung surfactant. An uncharged mutant of SP-B1-25 induced little change in the isotherms, suggesting that a specific charge interaction between the cationic peptide and the anionic lipid is responsible for the stabilization. The effect of SP-B1-25 on fatty acid isotherms is remarkably similar to that of simple poly-cations, suggesting that such polymers might be useful as components of replacement surfactants for the treatment of respiratory distress syndrome.
Time/Space Distributions of O2 in Running Fuel Cells (2008)

Abstract not Available.
CD8+ Cell Depletion of SHIV89.6P-Infected Macaques Induces CD4+ T Cell Proliferation that Contributes to Increased Viral Loads (2009)

Previous studies have shown that depletion of CD8(+) cells during acute and chronic simian immunodeficiency virus (SIV) infection leads to increased viral replication, morbidity, and mortality, which have been attributed to loss of CD8(+) T cell-mediated control of SIV. However, these studies did not exclude that CD8(+) cell depletion increased homeostatic proliferation of CD4(+) T cells, resulting in increased viral targets and, therefore, viral rebound. Chronically SHIV89.6P-infected cynomolgus macaques were CD8(+) cell-depleted, and the frequency, cell number, and phenotype of CD4(+) T cells and viral infection were examined using flow cytometry and quantitative real-time PCR. The frequency and number of Ki-67-expressing CD4(+) T cells were increased with CD8(+) cell depletion. This proliferation of CD4(+) T cells occurred even in animals with no rebound of viral loads. Most of the proliferating cells were effector memory CD4(+) T cells. Plasma simian HIV (SHIV) RNA copies positively correlated with proliferating CD4(+) T cells and SHIV DNA copies in Ki-67(+) CD4(+) T cells. Although this study does not exclude an important role for virus-specific CD8(+) T cells in SIV and SHIV infection, our data suggest that homeostatic proliferation is an important contributor to increases in plasma viremia that follow CD8(+) cell depletion.
Social-WaGDAT: Interaction-aware Trajectory Prediction via Wasserstein Graph Double-Attention Network (2020)

Effective understanding of the environment and accurate trajectory prediction of surrounding dynamic obstacles are indispensable for intelligent mobile systems (like autonomous vehicles and social robots) to achieve safe and high-quality planning when they navigate in highly interactive and crowded scenarios. Due to the existence of frequent interactions and uncertainty in the scene evolution, it is desired for the prediction system to enable relational reasoning on different entities and provide a distribution of future trajectories for each agent. In this paper, we propose a generic generative neural system (called Social-WaGDAT) for multi-agent trajectory prediction, which makes a step forward to explicit interaction modeling by incorporating relational inductive biases with a dynamic graph representation and leverages both trajectory and scene context information. We also employ an efficient kinematic constraint layer applied to vehicle trajectory prediction which not only ensures physical feasibility but also enhances model performance. The proposed system is evaluated on three public benchmark datasets for trajectory prediction, where the agents cover pedestrians, cyclists and on-road vehicles. The experimental results demonstrate that our model achieves better performance than various baseline approaches in terms of prediction accuracy.
Making Optimal Pump Scheduling Models Work (2010)

A great deal of research has been conducted on optimizing pumping operation but such optimization is still not widely used. This paper discusses some of the issues in applying optimal scheduling to realistic system and suggests how to make such methods work in practice.
Exploiting Application Tolerance for Functional Safety (2021)

As the use of safety critical systems is becoming more prevalent, there is a need to reduce the implementation overhead required to provide safety. The conventional design of such systems does not consider application behaviours, thereby resulting in a pessimistic design where the safety provided is often not required during large periods of the application execution. In this paper, we analyse the different phases of an application during its overall execution life cycle, together with the embedded threads to perform specific operations, and propose a new methodology for protection of the safety critical application threads. We show the benefits of this method and the ability to build lower cost systems which are functionally safe using the flexibility which is embedded inside the application itself. Two new application based protection schemes, based on altering the application execution parameters (e.g. control loop frequency) and redundant execution of selective threads, are proposed. For these experiments, we have used commercial off the shelf components without any hardware functional safety features and implemented safety measures by augmenting the application software. Experiments on Electric Vehicle Traction (EVT) and On-Board Charger (OBC) applications indicate overall MIPS savings between 70% to 95%. These results indicate that a careful design of the application can itself be the first step to protect the integrated circuits which drive them.
Evidence for hole injection from oxygen(1.DELTA.) into p-silicon (1989)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTEvidence for hole injection from oxygen(1.DELTA.) into p-siliconMichael Graetzel and Heinz FreiCite this: J. Phys. Chem. 1989, 93, 20, 7037–7041Publication Date (Print):October 1, 1989Publication History Published online1 May 2002Published inissue 1 October 1989https://pubs.acs.org/doi/10.1021/j100357a001https://doi.org/10.1021/j100357a001research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Subacute Minimally Invasive Decompression of L5 and S1 Nerve Roots for Neurologic Deficit After Fixation of Unstable Pelvic Fracture (2020)

The courses of the L5 and S1 nerve roots place them at risk of compression within the fracture during transsacral screw fixation. In highly comminuted fractures, avoidance of compression screws or use of intraoperative CT might prevent this complication. Direct nerve root decompression alone can be a successful treatment.
Monolithic integration of a semiconductor optical amplifier and a high bandwidth p-i-n photodiode using asymmetric twin-waveguide technology (2003)

An optical mode transformer, a semiconductor optical amplifier (SOA), and a high-bandwidth waveguide-coupled photodiode are monolithically integrated using separately optimized materials based on asymmetric twin-waveguide (ATG) technology. Incident light is collected by a diluted, large fiber guide followed by transfer to an SOA. After amplification, light is coupled into the uppermost In/sub 0.53/Ga/sub 0.47/As light absorption layer by two consecutive taper couplers. The device shows a peak responsivity of 11 A/W (/spl sim/12.5-dB SOA-to-detector gain) and a 3-dB electrical bandwidth of 36 GHz, corresponding to a gain-bandwidth product of 640 GHz. In this SOA/p-i-n chip, separation of optical functions (light guiding, amplification, and detection) into different waveguides allows for optimization of materials for each function without material regrowth. Generalized photonic integrated circuits containing complex combinations of these three optical functions can be realized using the integration scheme demonstrated here.
Bony ingrowth potential of 3D-printed porous titanium alloy: a direct comparison of interbody cage materials in an in vivo ovine lumbar fusion model (2018)

A direct comparison of interbody implants demonstrates significant and measurable differences in biomechanical, µ-CT, and histologic performance in an ovine model. The 3D-printed porous titanium interbody cage resulted in statistically significant reductions in ROM, increases in the bone ingrowth profile, as well as average construct stiffness compared with PEEK and PSP.
The Auditory Image (2017)

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Regulation of Human Cytotoxic Responses by Complement: C3, C3b and C3d Preparations Enhance Human Allogeneic Cytotoxic Responses (1986)

Complement components and complement breakdown products have been found to participate in the regulation of the immune response. In the present study we investigated the effect of C3 and its fragments, C3b, C3c and C3d on human allogeneic cell mediated lympholysis (CML). C3 and C3b at a concentration of 275 M X 10(-9) and C3d at a concentration of 330 M X 10(-9) enhanced human allogeneic CML by at least two fold. In contrast C3c did not affect CML responses. Both C3b and C3d had to be present at the initiation of the cultures in order to exert their effect. Similar doses of C3b and C3d did not affect the mixed lymphocyte responses (3H-thymidine uptake) while higher doses were clearly inhibitory. None of the preparations induced proliferative or cytotoxic responses in the absence of allogeneic stimulating cells. C3b and C3d added to the mixed lymphocyte cultures caused increased production of interleukin 2. We conclude that C3b and C3d facilitate allogeneic cytotoxic responses through increased production of interleukin 2.
Coupling Routing Algorithm and Data Encoding for Low Power Networks on Chip (2015)

The routing algorithm used in a Network-on-Chip (NoC) has a strong impact on both the functional and non functional indices of the overall system. Traditionally, routing algorithms have been designed considering performance and cost as the main objectives. In this study we focus on two important non functional metrics, namely, power dissipation and energy consumption. We propose a selection policy that can be coupled with any multi-path routing function and whose primary goal is reducing power dissipation. As technology shrinks, the power dissipated by the network links represents an ever more significant fraction of the total power budget. Based on this, the proposed selection policy tries to reduce link power dissipation by selecting the output port of the router which minimises the switching activity of the output link. A set of experiments carried out on both synthetic and real traffic scenarios is presented. When the proposed selection policy is used in conjunction with a data encoding technique, on average, 31% of energy reduction and 37% of power saving is observed. An architectural implementation of the selection policy is also presented and its impact on cost (silicon area) and power dissipation of the baseline router is discussed.