gebhart/patrepeval huggingface dataset:
Characteristics of triplex-directed photoadduct formation by psoralen-linked oligodeoxynucleotides (1995)

A triplex-forming oligopyrimidine has been attached at its 5'-end to a photoreactive psoralen derivative and used to target a sequence which forms part of the coding region of the human aromatase gene. The 20 base pair sequence is not a perfect triplex target since it contains three pyrimidine interruptions within the purine-rich strand. Despite this, we have detected triplex-directed photoadduct formation at pH 7.0 between the psoralen-linked oligonucleotide and a 30mer duplex representing the aromatase target. Photoadduct formation was found to be sensitive to pH, temperature, cation concentration and the base composition of the third strand. By varying the base sequence of the target duplex around the psoralen intercalation site, we have characterised the site and mode of psoralen intercalation. The attached psoralen has been found to intercalate at the triplex-duplex junction with a strong preference for one orientation. We have shown that the psoralen will bind at the junction even when there is a preferred TpA step at an adjacent site. We have also compared the binding affinity and photoreactivity of oligodeoxyribonucleotides linked to two different psoralen derivatives and found differences in the rate of crosslinking and the extent of crosslink formation. Finally, we have examined oligodeoxyribonucleotides which are attached to psoralen by polymethylene linkers of different lengths.
Rapidly-exploring Random Belief Trees for motion planning under uncertainty (2011)

In this paper we address the problem of motion planning in the presence of state uncertainty, also known as planning in belief space. The work is motivated by planning domains involving nontrivial dynamics, spatially varying measurement properties, and obstacle constraints. To make the problem tractable, we restrict the motion plan to a nominal trajectory stabilized with a linear estimator and controller. This allows us to predict distributions over future states given a candidate nominal trajectory. Using these distributions to ensure a bounded probability of collision, the algorithm incrementally constructs a graph of trajectories through state space, while efficiently searching over candidate paths through the graph at each iteration. This process results in a search tree in belief space that provably converges to the optimal path. We analyze the algorithm theoretically and also provide simulation results demonstrating its utility for balancing information gathering to reduce uncertainty and finding low cost paths.
Polarization Effects of Fluorine on the Relative Permittivity in Polyimides (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolarization Effects of Fluorine on the Relative Permittivity in PolyimidesG. Hougham, G. Tesoro, A. Viehbeck, and J. D. Chapple-SokolCite this: Macromolecules 1994, 27, 21, 5964–5971Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/ma00099a006https://doi.org/10.1021/ma00099a006research-articleACS PublicationsRequest reuse permissionsArticle Views1240Altmetric-Citations221LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Silicon Jungle: A Novel of Deception, Power, and Internet Intrigue (2011)

What happens when a naive intern is granted unfettered access to people’s most private thoughts and actions? Stephen Thorpe lands a coveted internship at Ubatoo, an Internet empire that provides its users with popular online services, from a search engine and e-mail, to social networking. When Stephen’s boss asks him to work on a project with the American Coalition for Civil Liberties, Stephen innocently obliges, believing he is mining Ubatoo’s vast databases to protect people unfairly targeted in the name of national security. But nothing is as it seems. Suspicious individuals surface, doing all they can to access Ubatoo’s wealth of confidential information. This need not require technical wizardry—simply knowing how to manipulate a well-intentioned intern may be enough. The Silicon Jungle is a cautionary fictional tale of data mining’s promise and peril. Baluja raises ethical questions about contemporary technological innovations, and how minute details can be routinely pieced together into rich profiles that reveal our habits, goals, and secret desires—all ready to be exploited.
Lateral Collateral Ligament Repair Restores the Initial Varus Stability of the Elbow: An In Vitro Biomechanical Study (2008)

These in vitro data suggest that LCL repair using transosseous sutures is a useful technique to restore the initial kinematics of the elbow. An LCL repair tension of 20 N or perhaps slightly less should be employed in clinical studies to confirm these laboratory observations.
Using Polymer Confinement for Stem Cell Differentiation: 3D Printed vs Molded Scaffolds. (2016)

Additive manufacturing technologies are increasingly being used to replace standard extrusion or molding methods in engineering polymeric biomedical implants, which can be further seeded with cells for tissue regeneration. The principal advantage of this new technology is the ability to print directly from a scan and hence produce parts which are an ideal fit for an individual, eliminating much of the sizing and fitting associated with standard manufacturing methods. The question though arises whether devices which may be macroscopically similar, serve identical functions and are produced from the same material, interact in the same manner with cells and living tissue. Here we show that fundamental differences can exist between 3-D printed and extruded scaffolds which can impact stem cell differentiation and lineage selection. We will show how polymer confinement inherent in these methods affect the printed features on multiple length scales. We will also and how the differentiation of stem cells is affected by substrate heterogeneity in both morphological and mechanical features.
Relative Variability in Bioavailability of Oral Controlled-Release Formulations of Oxycodone and Morphine (2001)

A retrospective analysis compared the coefficients of variation associated with the maximum plasma concentration (Cmax) and the extent of absorption (area under the curve [AUC] from 0 hour to the last observation) for oral, controlled-release tablet formulations of oxycodone (OxyContin) and morphine (MS Contin). Data from fasting, male subjects aged 18 to 45 years were taken from five controlled-release oxycodone (N = 82) and seven controlled-release morphine (N = 101) single-dose, bioequivalence studies. The coefficients of variation of Cmax and AUC were approximately 33% less for controlled-release oxycodone than for controlled-release morphine (P =.005). The variation from the minimum to maximum value was two to three times less for controlled-release oxycodone than for controlled-release morphine. Among healthy male subjects, the absorption of oxycodone from oral controlled-release oxycodone was significantly more consistent than the absorption of morphine from oral controlled-release morphine in terms of both maximum absorption and extent of absorption.
Orientation Mapping by Electron Channeling (OMEC) of Polycrystals Using a Stage-Rocked Big-Data Approach (2018)

Obtaining an accurate and precise measure of orientation in a polycrystalline material is a crucial characterization step in making structure/property connections in functional materials. In the past, understanding polycrystalline texture was frequently explored using selected area electron channeling patterns (SACP). By tilting the electron beam in fine increments on a polished specimen, observed changes in BSE contrast can be described by a superposition of Bloch waves which are highly dependent on the orientation of the crystal lattice. Recording this intensity directly onto a sphere, a map of orientation space can be made. Tilting the electron beam to large angles while maintaining a fixed position was nontrivial and suffered from spherical aberration, limiting both the spatial resolution and angular field of view (FOV). Electron Backscatter Diffraction (EBSD) is relatively immune to these challenges, and with computational assistance has become a turnkey technique to produce high (although anisotropic) spatial resolution orientation maps. However, angular resolution has remained limited by the pixel density of the detector and the inherent geometric distortions from recording electrons from a tilted specimen onto an oblique detector. In this work, we will show how an orientation map complementary to EBSD can be generated from a stage-rocked sample in a conventional SEM, where full rastered BSE images are recorded at each tilt/rotation.
Infection After Unicompartmental Knee Arthroplasty: A High Risk of Subsequent Complications (2018)

Level IV, therapeutic study.
Relationship of Ultrasonic Spectral Parameters to Features of Tissue Microstructure (1987)

Absfract-&mlytical studies have been conducted to investigate the importance of specific tissue features in determining ultrasonic spectral “signatures” that have proven to be diagnostically useful. Three models of tissue microstructure were considered, and calibrated power spectra were computed for a series of scatterer sizes, concentrations, and acoustic impedances. General results were obtained, then specific parameters were employed to simulate studies of the eye and liver. These results were compared to clinical data-base information, and excellent correspondence was found. Studies using acoustic microscopy, test objects, and clinical data are continuing to refine the analytical model. I. INTRODUCTION U
DOP73 Efficacy and safety of escalation to tofacitinib 10 mg BID for patients with UC following loss of response on 5 mg BID maintenance therapy: Results from OCTAVE open-label, long-term extension study (2020)

Abstract Background Tofacitinib is an oral, small-molecule JAK inhibitor for the treatment of ulcerative colitis (UC). The efficacy and safety of tofacitinib have been demonstrated in patients with moderate to severe UC in three Phase 3 studies (OCTAVE Induction 1 and 2 [NCT01465763; NCT01458951]; OCTAVE Sustain [NCT01458574]) [1]. Here, we present updated efficacy and safety data of tofacitinib dose escalation in patients with UC participating in an ongoing, open-label, long-term extension (OLE) study (OCTAVE Open, NCT01470612) [2]. Methods We present updated data from the dose-escalation subpopulation of the OLE study (as of May 2019; database not locked) comprising patients who achieved clinical response (CR) following 8 weeks of tofacitinib 10 mg twice daily (BID) induction therapy, entered OCTAVE Sustain receiving tofacitinib 5 mg BID, experienced treatment failure between Week 8 and Week 52, and subsequently entered OCTAVE Open with escalation to tofacitinib 10 mg BID. Treatment failure was defined as an increase of ≥3 points from maintenance study baseline total Mayo score, plus an increase of ≥1 point in both rectal bleeding subscore and centrally read endoscopic subscore (ES), and an absolute ES of ≥2 after ≥8 weeks of maintenance therapy. CR, mucosal healing (MH) and remission (R) were evaluated at Months 2, 12, 24 and 36 of OCTAVE Open (non-responder imputation and last observation carried forward [NRI-LOCF] and observed data). Safety was evaluated throughout the study. Results Of 944 patients enrolled in the OLE study, the dose escalation subpopulation comprised 59 patients. In these patients, CR, MH and R rates 36 months after dose escalation were, respectively, 40.7%, 39.0% and 30.5% for NRI-LOCF and 95.2%, 86.4% and 66.7% for observed data (Table). Of these 59 patients, 29 had prior tumour necrosis factor inhibitor (TNFi) failure; in these patients, CR, MH and R rates at Month 36 were, respectively, 51.7%, 51.7% and 41.4% for NRI-LOCF, and 100.0%, 92,3% and 75.0% for observed data. Incidence rates for safety events and pt-years’ exposure are reported in the table. Conclusion For most patients who lost initial CR to tofacitinib 10 mg BID induction therapy while on tofacitinib 5 mg BID maintenance therapy, including those with prior TNFi failure, dose-escalation back to 10 mg BID recaptured CR by Month 2 and was generally maintained over 3 years. The safety profile with tofacitinib 10 mg BID in the dose-escalation subpopulation was generally consistent with that in the overall study population, although there was a numerically higher rate of herpes zoster. These analyses are limited by low pt numbers and the absence of a comparator arm. References
Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling (2015)

Our findings indicate that TBI-induced IL12 augments Tc17 cell-mediated tumor immunity and underline the substantial implications of in vitro preparation of antitumor Tc17 cells with IL12 in the design of T-cell immunotherapies.
Column‐based model of electric field excitation of cerebral cortex (2004)

A model to explain the orientation selectivity of the neurophysiologic effects of electric-field transients applied to cerebral cortex is proposed and supported with neuroimaging evidence. Although it is well known that transcranial magnetic stimulation (TMS) excites cerebral cortex in an orientation-selective manner, a neurophysiologically compelling explanation of this phenomenon has been lacking. It is generally presumed that TMS-induced excitation is mediated by horizontal fibers in the cortical surfaces nearest to the stimulating coil, i.e., at the gyral crowns. No evidence exists, however, that horizontal fibers are orientation selective either anatomically or physiologically. We used positron emission tomography to demonstrate that TMS-induced cortical activation is selectively sulcal. This observation allows the well-established columnar organization of cerebral cortex to be invoked to explain the observed orientation selectivity. In addition, Rushton's cosine principle can used to model stimulation efficacy for an electrical field applied at any cortical site at any intensity and in any orientation.
Groundwater Pollution Prevention and Control in China: Current Status and Countermeasures (2022)

Groundwater is a significant source of drinking water and a strategic resource for China. However, the groundwater quality in China is unoptimistic and China faces a severe situation regarding groundwater environment protection as its groundwater pollution prevention and control started late. Therefore, problems faced by groundwater pollution prevention and control should be researched and targeted countermeasures be proposed to curb the trend of groundwater pollution and improve groundwater quality. The study reviews the existing regulations and policies, management status, and requirements of groundwater pollution prevention and control in China, and predicts the future management trend. The results indicate the following challenges. (1) The groundwater pollution status is still unclear and hierarchical and classified management of groundwater pollution is lacking. (2) The groundwater pollution forms become increasingly complex and the regulatory system requires improvement. (3) The groundwater pollution control becomes increasingly difficult and only few control technologies were applied to underground pollution treatment. (4) The requirements of groundwater environmental management are constantly improving; however, the innovation impetus is insufficient. Therefore, we proposed several countermeasures. The pollution status should be identified through continuous investigation and assessment of groundwater environment in key regions, to support the construction of a hierarchical and classified management system. Intelligent, visualized, and coordinated supervision should be achieved by establishing a multilevel groundwater environmental monitoring network and adopting supervisory measures based on information technologies. Green and sustainable models should be formed and promoted through the experimental implementation of groundwater pollution prevention and control projects and by constructing 21 pilot sites. The original innovation and management capacities should be enhanced by focusing on key technical issues such as groundwater pollution traceability, standards system construction, and development of relevant software with proprietary intellectual property rights.
A single-crystal silicon DC-40 GHz RF MEMS switch (2009)

This paper presents a new DC-40 GHz RF MEMS switch whose moving part is made of single-crystal silicon (SCS). Unlike thin-film metals commonly employed in RF MEMS switches, SCS is essentially defect-free, has well known and repeatable material properties and is virtually stress free. This makes the switch design insensitive to process variations and amenable to high-yield manufacturing. Measured RF switches exhibit an on state insertion loss of less than 0.3 dB and an off state isolation of higher than 30 dB up to 40 GHz. Measured switching time is less than 4 us.
Application of Alloy 718 in GE Aircraft Engines: Past, Present and Next Five Years (2001)

GE Aircraft Engine's interest in Alloy 718 dates to the early 1960's. New jet engines were under development for the Supersonic Transport (SST) and the Air Force's C-5A, the first of the wide-body airplanes. These new engines required a stronger, more temperature-capable alloy than A286, without the fabrication limitations of Rene 41. Alloy 718 subsequently became the most widely used superalloy for aerospace applications. It is the alloy most used at GE Aircraft Engines (GEAE) with application in critical rotating parts, airfoils, supporting structures and pressure vessels.
The efficient cellular uptake of high density lipoprotein lipids via scavenger receptor class B type I requires not only receptor-mediated surface binding but also receptor-specific lipid transfer mediated by its extracellular domain. (1998)

Page 26343, Fig. 3: The quality of the reproduction of this figure was unsatisfactory. The figure is reprinted below.
Mobile TV - The Concept Overview and Technology Enablers (2007)

Summary form only given. Bringing TV experience to the mobile users opens up a new era in the evolution of the mobile systems. Even if it started as a mere copying of the linear TV distribution of today, the mobile systems technologies that can provide feedback channels from every user enable new ways of enhancing the TV experience. So besides just watching TV via broadcast or on demand, a whole myriad of possibilities is enabled where the end-user can actively participate in the interactivity sessions with the content provider and indirectly with other viewers. Further, more sophisticated terminals enable pre-recording of the subscribed content to be consumed at the user's convenience. Today, 3G wireless systems offer a superior streaming capabilities for TV distribution, either as unicast service (e.g. HSPA) or broadcast service (e.g. MBMS). Actually, the best utilization of the resources is provided with a combination of the unicast and broadcast services, where unicast part is used in areas with lower demand and for offering basically unlimited number of channels, while broadcast part is used as a capacity booster in areas where several users are interested in the same content. There are also alternative pure broadcast technologies like DVB-H, DMB, ISDB-T and MediaFLO that are gaining traction in different parts of the world but to provide interactivity they must be integrated with some cellular system. That makes the Mobile TV market segmented for the time being but the near future will show what model is capable of gaining the largest momentum thus creating mass market for Mobile TV.
Long-term effects of pravastatin on serum lipid levels in elderly patients with hypercholesterolemia. (1995)

The purpose of this study was to evaluate the long-term efficacy and tolerability of pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in elderly patients with hypercholesterolemia. Pravastatin was administered for 12 months at a mean final dose of 9.9 mg/d to 208 elderly patients (mean [+/- SD] age, 70 +/- 7 years) with levels of total serum cholesterol greater than 5.69 mmol/L. The mean total cholesterol level was significantly decreased from 6.85 +/- 0.80 mmol/L to 5.59 +/- 0.70 mmol/L after 3 months, and this decrease was maintained thereafter. A similar change was observed in the mean serum level of low-density lipoprotein cholesterol. Although the mean serum level of high-density lipoprotein cholesterol in all the patients did not change significantly, the level in 34 patients with a value lower than 1.03 mmol/L was significantly increased after 3 months and thereafter. The serum level of triglycerides in all patients was significantly decreased after 3 months and thereafter and the decrease was more marked in 101 patients with levels greater than 1.73 mmol/L. In 168 elderly patients receiving 10 mg/d of pravastatin, there were significant negative correlations between the percent decrease in total cholesterol and both baseline total serum cholesterol level (r = -.354, P < 0.001) and age (r = -.208, P = 0.007). No serious side effects were observed. These results indicate that long-term administration of pravastatin is beneficial in the treatment of hypercholesterolemia in elderly patients.
High-throughput multimodal Raman-fluorescence flow cytometry (Conference Presentation) (2020)

We present a high-throughput multimodal Raman-fluorescence flow cytometer that produces simultaneous Raman and fluorescence excitation spectra at a demonstrated throughput of 100 events per second. Our method combines Fourier-transform coherent anti-Stokes Raman scattering with Fourier-transform two-photon excitation fluorescence, which produces broadband Raman spectra that span the biological fingerprint region and single-detector multicolor fluorescence via spectral analysis. As a proof-of-principle demonstration, we perform multimodal label-free analysis of stress response in the microalga Haematococcus pluvialis by Raman measurement of its secondary metabolite astaxanthin and two-color fluorescence measurement of chlorophyll and fluorescent chlorophyll catabolites under different stress conditions.