gebhart/patrepeval huggingface dataset:
Surrogate Modelling of Active Flow Control (2023)

View Video Presentation: https://doi.org/10.2514/6.2023-2314.vid The development of a surrogate model for predicting aerodynamic force and moment increments due to three active flow control technologies for aircraft conceptual design is discussed in this paper. The active flow control technologies are: supercritical circulation control for roll, pitch and yaw control; forebody blowing for yaw control; and high-lift boundary layer control for augmentation of conventional control surfaces. These models were developed because existing empirical methods for predicting conceptual design aerodynamics are unable to estimate the aircraft response due to these active flow control technologies. The geometric parameterisation of the flow control technologies and the approach to incorporate aircraft planform influences on active flow control is presented. Data for the surrogate model consisted of a combination of existing data from literature, experiments, and a large database of computational fluid dynamics results generated specifically for the model. An overview of the data processing is given, and finally comparisons between the surrogate model and full three-dimensional computational fluid dynamics simulations of an aircraft are presented. The surrogate model is shown to predict the aerodynamic response of active flow control to levels of accuracy sufficient for conceptual design, and make predictions in timescales suitable for real-time flight simulation software.
A Hybrid Artificial Intelligence Method to Predict Gas Solubility and Bubble Point Pressure (2017)

Abstract Bubble point pressure (Pb) and gas solubility (Rs) are reservoir fluid properties that have significant effect on oil reservoir characterization and reservoir engineering computations. Better knowledge of these PVT properties improve the reliability of reservoir simulation. Perfectly, these properties should be obtained from actual laboratory measurements. However, these measurements are either not available or very costly to be obtained. For these reasons, there is a need for a quick and reliable method for predicting these PVT properties. There are numerous approaches for predicting PVT properties, namely, empirical correlations and computational intelligence schemes. The objective of this research is to develop reliable model by utilizing a novel comprehensive approach using hybrid Self-adaptive Differential Evolution and Artificial Neural Network (SaDE-ANN) that could be used as a robust and effective model to predict Pb and Rs of crude oils based only on oil and gas gravities in addition to the reservoir temperature. This model was developed using data sets collected from published sources. Statistical error analysis was also used to check the validation of the two proposed empirical correlations introduced based on the weights and biases of the developed SaDE-ANN model. Based on the results generated by the proposed model compared with other conventional methods, that SaDE-ANN model is a reliable and accurate approach for predicting Pb and Rs of crude oils with a high accuracy and correlation coefficient of 99%. The developed approach is inexpensive with no additional required equipment or tools. This paper, for the first time, introduced a novel approach that utilizing only on three input parameters; oil gravity, gas gravity and reservoir temperature to predict Pb and Rs of crude oils. This approach has not been applied or investigated before this research. Therefore, it is a step forward to eliminate the required PVT lab experiments and discover the capabilities of hybrid optimization and artificial intelligence models as well as their application in predicting PVT properties. Outcomes of this study could help reservoir engineers to have better understanding of reservoir fluid behavior when experimental data samples are not available.
Asymmetric printing of molecules and zeolites on self assembled monolayers (2010)

Microcontact printing (mCP) is used to immobilize dyes and peptides asymmetrically, by a "peptide coupling" reaction, on monolayers of zeolite L crystals in the contact area between the stamp and the surface of the monolayer. Chemically patterned surfaces of monolayers of zeolite L crystals are obtained by using patterned stamps with different ink solutions. Additional printing of functionalized nano-objects on SAMs of zeolite L crystals is demonstrated.
114-I * CLOSING THE GAP: FIRST RESULTS OF THE NEW 15-ML EXCOR PUMP FOR CHILDREN (2014)

Objectives: Berlin Heart EXCOR (BHE) is an important device for bridging children to heart transplantation. However, between the smallest pump (10 ml) and the next size (25 ml) there was still a remarkable gap in terms of perfect pump performance. We describe the first clinical results of post CE-mark early product surveillance (EPS) in Europe for the new 15-ml EXCOR pump. Methods: Nine patients [mean age 1.9 years, mean body surface area (BSA) 0.47 m2] were supported due to severe heart failure. Diagnosis was idiopathic cardiomyopathy in 5 children, ischaemic cardiomyopathy, myocarditis, post-transplant rejection and congenital heart disease in 1, respectively; 78% were in INTERMACS levels I and II. Two children were on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) before BHE (2 and 7 days of support). Data were analysed prospectively in a multicentre approach in 3 European high-volume paediatric heart surgery centres within the EPS (60 days follow-up). Results: All children were included in the study. There were 5 biventricular assist device (BIVAD) and 4 left ventricular assist device (LVAD). Mean length on support was 62 ± 57 days and median 33 days (range 14–182). Thirty-day and 60-day survivals were 100%. Two children were successfully explanted after 15 and 27 days of support. All other patients were successfully transplanted after a mean of 71 days on device. Within EPS time period, there were no device failures or severe adverse events (cerebrovascular accident, haematological sequelae, sepsis, multiorgan failure). Conclusion: The new 15-ml EXCOR pump showed excellent performance in post-market surveillance in Europe and seems to close the gap successfully. Further implantations are needed to confirm these first results.
Safety and efficacy of arcitumomab imaging in colorectal cancer after repeated administration. (2000)

These data indicate that at least 2 injections of arcitumomab can be given safely to patients with colorectal cancer, without increased immunogenicity and with imaging efficacy equivalent to the first administration.
Modified Sol−Gel Based Approaches for Synthesizing Borophosphosilicate Glasses and Glass-Ceramics (1998)

Modified sol−gel based processes were used to synthesize borophosphosilicate glasses and glass-ceramics, utilizing boron oxide and phosphorus pentoxide as starting precursors. In these processes, the alkoxides of boron and phosphorus were synthesized in situ using oxide precursors, which were then subjected to controlled or rapid hydrolysis and condensation reactions to form either gels (modified oxide sol−gel process: MOSG) or precipitate powders (modified oxide sol-precipitation process: MOSP). The dried gels and precipitates obtained in both processes were heat-treated to 800 °C to crystallize the BPO4 phase. The crystallinity of the as-prepared and heat-treated powders was analyzed using X-ray diffraction, while Fourier transform infrared spectroscopy (FTIR) was employed to identify the molecular linkages of the various components present. Results of these studies show that B−O−B species form during heat treatment of the MOSG-derived gels because of the presence of unreacted B−OH groups, leading to microsegregation of these units in the gels. However, these units are not detected in the powders obtained using the MOSP process, thereby suggesting differences in the gel structures. These structural differences lead to different pathways for the formation of BPO4 in the two processes. Nevertheless, independent of the process, both samples, although structurally different, exhibit almost the same extent of crystallization of BPO4 after heat treatment at 800 °C.
Does Multilevel Lumbar Stenosis Lead to Poorer Outcomes? (2010)

Patients with spinal stenosis without associated degenerative spondylolisthesis or scoliosis can be managed nonoperatively irrespective of the number of levels involved. If surgery is performed, the number of levels treated does not predict outcome. In contrast, patients with concomitant degenerative spondylolisthesis and single level stenosis do better surgically than those with additional levels of stenosis. This study emphasizes the importance of shared decision-making between the physician and patient when considering treatment for spinal stenosis.
How to design the catalyst (layer) for fuel cell using plasma techniques? (2015)

International audience
Cycloalkylpyranones and Cycloalkyldihydropyrones as HIV Protease Inhibitors:  Exploring the Impact of Ring Size on Structure−Activity Relationships (1996)

Previously, 3-substituted cycloalkylpyranones, such as 2d, have proven to be effective inhibitors of HIV protease. In an initial series of 3-(1-phenylpropyl) derivatives with various cycloalkyl ring sizes, the cyclooctyl analog was the most potent. We became interested in exploring the influence of other structural changes, such as substitution on the phenyl ring and saturation of the 5,6-double bond, on the cycloalkyl ring size structure-activity relationship (SAR). Saturation of the 5,6-double bond in the pyrone ring significantly impacts the SAR, altering the optimal ring size from eight to six. Substitution of a sulfonamide at the meta position of the phenyl ring dramatically increases the potency of these inhibitors, but it does not change the optimal ring size in either the cycloalkylpyranone or the cycloalkyldihydropyrone series. This work has led to the identification of compounds with superb binding affinity for the HIV protease (Ki values in the 10-50 pM range). In addition, the cycloalkyldihydropyrones showed excellent antiviral activity in cell culture, with ED50 values as low as 1 microM.
Effect of Celergen, a marine derivative, on in vitro hepatocarcinogenesis (2013)

The aim of this study was to test for a potential anticarcinogenic effect of Celergen, a marine derivative devoid of traceable amounts of inorganic arsenic, on cell proliferation, cell cycle progression and apoptosis in the HepG2 human liver cancer cell line. Celergen significantly inhibited the proliferation of cancer cells in a dose-dependent manner while limiting the cell cycle progression at the G1 phase and significantly inducing apoptosis. Further examination showed that Celergen enhanced expression of the p21(CIPl1WAF1), GADD153 genes and downregulated the c-myc gene. These results suggest that Celergen exerts promising chemopreventive properties to be further investigated.
Stabilization of PE/PEO Cocontinuous Blends by Interfacial Nanoclays (2015)

Organomodified clays are known to be effective in polymer blend compatibilization if located preferentially at the domain interfaces, but little is known regarding the origin of their localization. In this study, we investigate the effect of organomodifier, clay loading, and shear environment on the compatibilization extent in nonreactive polyethylene (LDPE)/poly(ethylene oxide) (PEO) and reactive maleic anhydride functional polyethylene (PE-g-MA)/PEO polymer blends. We pose important questions: If clay is to compatibilize blends by interfacial localization, how does organomodifier affect its localization? How does an increase in clay loading affect the shape and elasticity of the interface? What is the shear intensity needed to overcome the equilibrium distribution of clays and delaminate it from the interface? We utilize laser scanning confocal microscopy and 3D image analysis to calculate characteristic phase size and gain unique insights into the connection between the clay loading and the interfacial curvature. Our experiments demonstrate that 1 wt % of interfacially localized clay is sufficient to suppress coarsening and greatly reduce phase domains. However, further increase of clay loading only saw a marginal reduction in phase size compared to 1 wt % clay loading. The interfacial curvature calculations showed that with increase in clay loadings beyond 1 wt % the shape of the interface does not change significantly; however, slight broadening of curvature distribution and increasing asymmetry are observed from 3D images. This can be attributed to the multiple layers of clay jammed at the interface at higher clay loadings. When reactive PE-g-MA was substituted for LDPE, graft copolymers were generated via in situ coupling at the interface. These copolymers combined with clay resulted in the smallest phase domains. In addition, we show that clay dispersion and localization were largely independent of shear intensity, which suggests that clay does not delaminate from the interface even in high shear environments.
Investigations of the dispersion tolerance of the nonlinear optical transmission channel for different modulation formats in a WDM-system (2005)

We investigate the dispersion tolerance for nonlinear WDM transmission of the modulation formats ASK, DPSK, DQPSK and duobinary with NRZ as well as RZ pulse shape. We study different dispersion maps and determine for each modulation format an optimized dispersion map to examine the robustness against variations of the dispersion map and against nonlinear effects.
[New insights in frontotemporal dementia]. (2000)

Frontotemporal dementia (FTD) is a neurodegenerative disorder characterised by progressive behavioural disturbance, aphasia and a decline in frontal cognitive functions. Frontotemporal atrophy on CT and MRI, and hypoperfusion of the frontal brain regions on single-photon emission computed tomography (SPECT), are characteristic findings. Neuropathological examination reveals deposition of abnormally phosphorylated tau protein in neurons and glial cells in a number of the sporadic and familial cases, while aspecific changes with neuronal loss, spongiosis and gliosis are found in the remaining cases. A familial form with an autosomal dominant pattern of inheritance is seen in 20% of FTD patients. Mutations in the tau gene have been identified in a number of families with deposition of abnormal tau protein in affected brain regions. Presymptomatic DNA testing is now available for relatives of patients with tau mutations, but must only be considered after extensive genetic counselling in a centre with neurogenetic expertise.
Optimization and Analysis of Low Voltage Phosphors Deposited Electrophoretically for the FED Applications (1997)

Low voltage phosphors for the application to prototype 4-inch full color field emission display devices was successfully deposited on indium-tin oxide (ITO) glasses by utilizing an electrophoretic method. The electrophoretic suspension used consisted of each color phosphor of 1 -3um size, isopropyl alcohol (IPA), charger and binder. The deposition rate of each color phosphor was systematically investigated by changing deposition time and applied voltages under conditions of various nitrate salts, such as Mg(N03)2, La(NO3)2 and AI(N03)2. The brightness of each deposited phosphor were analyzed both in the vacuum chamber and in fully-sealed environment. Experimental results significantly exhibit uniform thickness of about 4-9um thickness over the whole 4 inch glass plate, depending on electrical properties of each color phosphor.
The Effects of a Wearable Sensory Prosthesis on Gait and Balance Function After 10 Weeks of Use in Persons With Peripheral Neuropathy and High Fall Risk – The walk2Wellness Trial (2020)

ClinicalTrials.gov (#NCT03538756).
Lymphoblastoid cell lines from patients with chronic lymphocytic leukemia: identification of tumor origin by idiotypic analysis. (1978)

Multiple lymphoblastoid cell lines have been derived from two patients with chronic lymphocytic leukemia with an associated monoclonal immunoglobulin (Ig) band. Idiotypic antisera raised against the monoclonal serum Ig bands were shown to be specific for the membrane Ig of the patients' leukemic cells. The idiotypic determinants in these patients thereby constitute tumor-specific antigens. Surface and intracellular immunofluorescence studies utilizing these idiotypic antisera were used to identify the cell lines of leukemic origin. These studies showed that certain cell lines from each patient were derived from the leukemic cells while other cell lines were derived from residual normal B lymphocytes. The leukemic cell lines were variable and contained different percentages of lymphoid cells with the idiotype-specific membrane Ig and, in addition, different percentages of plasma cells with intracellular Ig of the same specificity. Specific Ig synthesis was also demonstrated by hemagglutination-inhibition analysis of cell line supernatants. Aside from Ig specificity, no differences have been found between the leukemic cell lines and those derived from normal cells. One of the leukemic cell lines was cloned in soft agarose. All the clones were shown to be of leukemic origin.
Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+;Pdx-1-Cre mice by vitamin E -tocotrienol (2013)

The highly lethal nature of pancreatic cancer and the increasing recognition of high-risk individuals have made research into chemoprevention a high priority. Here, we tested the chemopreventive activity of δ-tocotrienol, a bioactive vitamin E derivative extracted from palm fruit, in the LSL-Kras(G12D/+);Pdx-1-Cre pancreatic cancer mouse model. At 10 weeks of age, mice (n = 92) were randomly allocated to three groups: (i) no treatment; (ii) vehicle and (iii) δ-tocotrienol (200mg/kg × 2/day, PO). Treatment was continued for 12 months. Mice treated with δ-tocotrienol showed increased median survival from the onset of treatment (11.1 months) compared with vehicle-treated mice (9.7 months) and non-treated mice (8.5 months; P < 0.025). Importantly, none of the mice treated with δ-tocotrienol harbored invasive cancer compared with 10% and 8% in vehicle-treated and non-treated mice, respectively. Furthermore, δ-tocotrienol treatment also resulted in significant suppression of mouse pancreatic intraepithelial neoplasm (mPanIN) progression compared with vehicle-treated and non-treated mice: mPanIN-1: 47-50% (P < 0.09), mPanIN-2: 6-11% (P < 0.001), mPanIN-3: 3-15% (P < 0.001) and invasive cancer: 0-10% (P < 0.001). δ-Tocotrienol treatment inhibited mutant Kras-driven pathways such as MEK/ERK, PI3K/AKT and NF-kB/p65, as well as Bcl-xL and induced p27. δ-Tocotrienol also induced biomarkers of apoptosis such as Bax and activated caspase 3 along with an increase in plasma levels of CK18. In summary, δ-tocotrienol's ability to interfere with oncogenic Kras pathways coupled with the observed increase in median survival and significant delay in PanIN progression highlights the chemopreventative potential of δ-tocotrienol and warrants further investigation of this micronutrient in individuals at high risk for pancreatic cancer.
Novel Complement C5 Small-interfering RNA Lipid Nanoparticle Prolongs Graft Survival in a Hypersensitized Rat Kidney Transplant Model (2022)

C5 siRNA-LNP combined with immunosuppressants CsA and DSG downregulated C5 activity and significantly prolonged graft survival compared with control siRNA-LNP with CsA and DSG. Downregulation of C5 expression using C5 siRNA-LNP may be an effective therapeutic approach for AMR.
Hablamos con Philip Roth (2009)

Secondary tumours of the penis are rare; they most commonly arise from the prostate and the bladder. These lesions are often associated with disseminated malignancy and have a poor prognosis, with a 6-month mortality of up to 80% reported. Penile metastases have a variety of clinical manifestations including incidental penile nodules, cutaneous findings, urinary symptoms, pain and malignant priapism. Treatment options are mainly targeted at improving the patients' quality of life and are tailored to their clinical condition, but are primarily palliative. This study reports a case of a 92-year-old man with a presentation of glandular penile metastases from prostate adenocarcinoma treated conservatively.
A high resolution single molecule sequencing-based Arabidopsis transcriptome using novel methods of Iso-seq analysis (2021)

Abstract Background Accurate and comprehensive annotation of transcript sequences is essential for transcript quantification and differential gene and transcript expression analysis. Single molecule long read sequencing technologies provide improved integrity of transcript structures including alternative splicing, and transcription start and polyadenylation sites. However, accuracy is significantly affected by sequencing errors, mRNA degradation or incomplete cDNA synthesis. Results We present a new and comprehensive Arabidopsis thaliana Reference Transcript Dataset 3 (AtRTD3). AtRTD3 contains over 160k transcripts - twice that of the best current Arabidopsis transcriptome and including over 1,500 novel genes. 79% of transcripts are from Iso-seq with accurately defined splice junctions and transcription start and end sites. We developed novel methods to determine splice junctions and transcription start and end sites accurately. Mis- match profiles around splice junctions provided a powerful feature to distinguish correct splice junctions and remove false splice junctions. Stratified approaches identified high confidence transcription start/end sites and removed fragmentary transcripts due to degradation. AtRTD3 is a major improvement over existing transcriptomes as demonstrated by analysis of an Arabidopsis cold response RNA-seq time-series. AtRTD3 provided higher resolution of transcript expression profiling and identified cold- and light-induced differential transcription start and polyadenylation site usage. Conclusions AtRTD3 is the most comprehensive Arabidopsis transcriptome currently available. It improves the precision of differential gene and transcript expression, differential alternative splicing, and transcription start/end site usage from RNA-seq data. The novel methods for identifying accurate splice junctions and transcription start/end sites are widely applicable and will improve single molecule sequencing analysis from any species.