gebhart/patrepeval huggingface dataset:
An intelligent admission control scheme for next generation wireless systems using distributed genetic algorithms (2004)

A different variety of services requiring different levels of quality of service (QoS) need be addressed for mobile users of the next generation wireless system (NGWS). An efficient handoff technique with intelligent admission control can accomplish this aim. In this paper, a new, intelligent handoff scheme using distributed genetic algorithms (DGA) is proposed for NGWS. This scheme uses DGA to achieve high network utilization, minimum cost and handoff latency. A performance analysis is provided to assess the efficiency of the proposed DGA scheme. Simulation results show a significant improvement in handoff latencies and costs over traditional genetic algorithms and other admission control schemes.
Apoptosis and Suppression of Tumor Growth by Artepillin C Extracted from Brazilian Propolis (1998)

Artepillin C was extracted from Brazilian propolis. Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) has a molecular weight of 300.40 and possesses antibacterial activity. When artepillin C was applied to human and murine malignant tumor cells in vitro and in vivo, artepillin C exhibited a cytotoxic effect and the growth of tumor cells was clearly inhibited. The artepillin C was found to cause significant damage to solid tumor and leukemic cells by the MTT assay, DNA synthesis assay, and morphological observation in vitro. When xenografts of human tumor cells were transplanted into nude mice, the cytotoxic effects of artepillin C were most noticeable in carcinoma and malignant melanoma. Apoptosis, abortive mitosis, and massive necrosis combined were identified by histological observation after intratumor injection of 500 microg of artepillin C three times a week. In addition to suppression of tumor growth, there was an increase in the ratio of CD4/CD8 T cells, and in the total number of helper T cells. These findings indicate that artepillin C activates the immune system, and possesses direct antitumor activity.
Role of magnesium in etiology of hypertension and atherosclerosis: is Mg/sup 2+/ a second messenger in cardiac and vascular muscle (1988)

Evidence is reviewed which implicates a modulatory role for magnesium (Mg) in the control of arterial blood pressure, vascular tone and lipid metabolism. The evidence is beginning to become persuasive in implicating lower than normal dietary intake of Mg in the etiology of some forms of hypertension, ischemic heart disease (IHD) and atherosclerosis. Hypomagnesemic states in hospitalized patients, particularly those subjects with cardiovascular disease, is becoming more frequent and a serious risk factor for cardiac arrhythmias and stroke. Experimental evidence is presented which demonstrates that Mg deficiency can lead to hypertension, atheromas and coronary vasospasm. Therapy with Mg in several forms of experimental hypertension and atherosclerosis is efficacious. Evidence is also presented to indicate that the (Mg/sup 2+/)/degree/ controls myocardial cellular bioenergetics at the cytosolic and mitochondrial levels. Lastly, the data implicates Mg/sup 2+/ as a true intracellular regulatory cation and most likely as a second messenger.
Figure from Somatic Epigenetic Silencing of <i>RIPK3</i> Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma (2023)

&lt;p&gt;DNA methyltransferase DNMT1 suppresses RIPK3 transcription. A, Immunoblot analysis of MM cells with knockdown of DNMT1 protein (184 kDa) expression. RIPK3-negative cells were transfected with two siRNAs against DNMT1 or an siControl (siCon), and DNMT1 protein levels were determined by immunoblot analysis 72 hours post-transfection. B, Semi-quantitative RT-PCR to detect knockdown of DNMT1 (500 bp), re-expression of RIPK3 (700 bp), as well as expression of control GAPDH (800 kDa).&lt;/p&gt;
ChemInform Abstract: Steroids. Part 339. Brassinolide Analogues without Side Chain. (1989)

Abstract Brassinolide analogues of type (IIa), (IV) and (V) are subjected to the second bean internode bioassay.
Biphasic Ni-Catalyzed Ethylene Oligomerization in Ionic Liquids (2007)

Diimine nickel complexes activated with aluminoxane in chloroaluminate ionic liquids are highly active catalysts either for the biphasic ethylene oligomerization or for polymerization depending on the bulkiness of the diimine ligand. The activation of Ni(0) with a Brönsted acid in different non-chloroaluminate ionic liquids is also reported. The nature of the ionic liquid and the presence or not of a nitrogen ligand affect significantly the catalytic performances. The olefinic products are weakly soluble in ionic liquids and can be separated from the catalytic ionic phase by simple decantation. The nickel catalysts are immobilized and stabilized in the ionic liquids and can be recycled.
A phase II trial of olaparib and durvalumab in metastatic BRCA wild type triple-negative breast cancer. (2019)

TPS1111 Background: There is an urgent need to develop novel non chemotherapy treatments for metastatic triple negative breast cancer (mTNBC) patients who otherwise have a poor prognosis. Immune checkpoint blockade (ICB) and PARP inhibitors (PARPi) have independently shown promise for the treatment of mTNBC, and the combination has shown early benefit in the MEDIOLA and TOPACIO trials. This trial looks to 1) evaluate the efficacy of the combination of the PARPi olaparib and the PD-L1 inhibitor durvalumab, and 2) perform extensive multi-omics including protein based image analytics (multiplex IHC, cyclic immunofluorescence) on serial biopsies to identify predictive biomarkers and resistance mechanisms. Methods: Trial Design: This is a single-arm phase II study to assess the efficacy of the combination of olaparib and durvalumab in BRCA-wildtype mTNBC. mTNBC participants will undergo a pre-treatment biopsy, then will start a 4 week induction treatment with olaparib (300 mg PO BID). At the end of 4 weeks of single agent therapy, participants will undergo a repeat on-treatment biopsy, following which durvalumab (1500 mg IV every 4 weeks) will be added to olaparib. Participants will also be offered an optional biopsy on progression. Endpoints: The primary endpoint of this study is overall response rate (ORR) to olaparib and durvalumab therapy. Secondary efficacy endpoints include clinical benefit rate, duration of response, progression-free, and overall survival. The incidence and severity of on-treatment adverse events will be collected per CTCAE 5.0. Statistical Methods: 28 participants are planned for enrollment to this study. A 2-stage analysis will be performed using a Simon 2-stage Minimax design. The null (ICB alone) and alternative (ICB + PARPi) hypotheses are: H 0 : π = 0.15 and H a : π = 0.35. For the primary endpoint, a total sample size of 28 participants will achieve 80% power to detect the ORR difference of 0.20 with one-sided type I error =0.05. The trial will be terminated in stage I if 2 or less out of the first 15 participants respond. If the trial goes on to the stage II, a total of 28 participants will be studied. If the total number responding is less than or equal to 7, the combination is rejected. Current Enrollment: The study was activated on 1/7/2019. To date, 3 out of 15 patients have been accrued to stage I of the study Clinical trial information: NCT03801369.
Modulation-Domain Parametric Multichannel Kalman Filtering for Speech Enhancement (2018)

The goal of speech enhancement is to reduce the noise signal while keeping the speech signal undistorted. Recently we developed the multichannel Kalman filtering (MKF) for speech enhancement, in which the temporal evolution of the speech signal and the spatial correlation between multichannel observations are jointly exploited to estimate the clean signal. In this paper, we extend the previous work to derive a parametric MKF (PMKF), which incorporates a controlling factor to achieve the trade-off between the speech distortion and noise reduction. The controlling factor weights between the speech distortion and noise reduction related terms in the cost function of PMKF, and based on the minimum mean squared error (MMSE) criterion, the optimal PMKF gain is derived. We analyse the performance of the proposed PMKF and show the differences with the speech distortion weighted multichannel Wiener filter (SDW-MWF). We conduct experiments in different noisy conditions to evaluate the impact of the controlling factor on the noise reduction performance, and the results demonstrate the effectiveness of the proposed method.
An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets (2020)

Interleukin-27 (IL-27) is an immunoregulatory cytokine that suppresses inflammation through multiple mechanisms, including induction of IL-10, but the transcriptional network mediating its diverse functions remains unclear. Combining temporal RNA profiling with computational algorithms, we predict 79 transcription factors induced by IL-27 in T cells. We validate 11 known and discover 5 positive (Cebpb, Fosl2, Tbx21, Hlx, and Atf3) and 2 negative (Irf9 and Irf8) Il10 regulators, generating an experimentally refined regulatory network for Il10. We report two central regulators, Prdm1 and Maf, that cooperatively drive the expression of signature genes induced by IL-27 in type 1 regulatory T cells, mediate IL-10 expression in all T helper cells, and determine the regulatory phenotype of colonic Foxp3<sup>+</sup> regulatory T cells. Prdm1/Maf double-knockout mice develop spontaneous colitis, phenocopying ll10-deficient mice. Our work provides insights into IL-27-driven transcriptional networks and identifies two shared Il10 regulators that orchestrate immunoregulatory programs across T helper cell subsets.
Assumption Trade-Offs When Choosing Identification Strategies for Pre-Post Treatment Effect Estimation: An Illustration of a Community-Based Intervention in Madagascar (2014)

Failure (or success) in finding a statistically significant effect of a large-scale intervention may be due to choices made in the evaluation. To highlight the potential limitations and pitfalls of some common identification strategies used for estimating causal effects of community-level interventions, we apply a roadmap for causal inference to a pre-post evaluation of a national nutrition program in Madagascar. Selection into the program was non-random and strongly associated with the pre-treatment (lagged) outcome. Using structural causal models (SCM), directed acyclic graphs (DAGs) and simulated data, we illustrate that an estimand with the outcome defined as the post-treatment outcome controls for confounding by the lagged outcome but not by possible unmeasured confounders. Two separate differencing estimands (of the pre- and post-treatment outcome) have the potential to adjust for a certain type of unmeasured confounding, but introduce bias if the additional identification assumptions they rely on are not met. In order to illustrate the practical impact of choice between three common identification strategies and their corresponding estimands, we used observational data from the community nutrition program in Madagascar to estimate each of these three estimands. Specifically, we estimated the average treatment effect of the program on the community mean nutritional status of children 5 years and under and found that the estimate based on the post-treatment estimand was about a quarter of the magnitude of either of the differencing estimands (0.066 SD vs. 0.26-0.27 SD increase in mean weight-for-age z-score). Choice of estimand clearly has important implications for the interpretation of the success of the program to improve nutritional status of young children. A careful appraisal of the assumptions underlying the causal model is imperative before committing to a statistical model and progressing to estimation. However, knowledge about the data-generating process must be sufficient in order to choose the identification strategy that gets us closest to the truth.
Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent‐resistant membrane compartments (2006)

The incorrect version of Fig. 2 was published in the above paper. Please find below the correct version of this figure:
Investigation of Extra-Large Pore Zeolite Synthesis by a High-Throughput Approach (2011)

Seven isoindoline-based organic structure directing agents (OSDAs) with increasing sizes have been prepared and each applied in a high throughput (HT) design of 33 × 5 experiments by varying the synthesis parameters such as Si/Ge, Al(B)/(Si+Ge), F–/(Si+Ge), and H2O/(Si+Ge). Among the 945 experiments, 395 lead to crystalline zeolite products, corresponding to eight zeolites, i.e., Beta (3D 12 × 12 × 12 ring), ITQ-7 (3D 12 × 12 × 12 ring), ITQ-17 (3D 12 × 12 × 12 ring), ITQ-15 (2D 14 × 12 ring), ITQ-21 (3D 12 × 12 × 12 ring), ITQ-37(3D 30 ring), ITQ-43 (3D 28 × 12 × 12 ring), and ITQ-44 (3D 18 × 12 × 12 ring). Most of the crystalline phases obtained (85.8%, 339 of 395) are Beta, ITQ-7, ITQ-17, and intergrowths of ITQ-7 and ITQ-17, which have been named as “Default Structures” here. It has been found that concentrated gels and high Ge/Si ratio favor the formation of low framework density structures. When the OSDAs are relatively small, only “Default Structures” can be obtained, while if the size of OSDA increases above a certain dimension, extra-large pore zeolites such as ITQ-15, ITQ-37, ITQ-44, and ITQ-43 start to appear. The mesoporous chiral zeolite ITQ-37 has been successfully synthesized here with a much less costly achiral template than the one used originally. It has also been found that there is an intergrowth of ITQ-7 and ITQ-17 due to their closely correlated structures.
ChemInform Abstract: 4‐Hydroxyphenylpyruvate Dioxygenase Inhibitors in Combination with Safeners: Solutions for Modern and Sustainable Agriculture (2013)

Abstract Review: 42 refs.
Deterministic and continuous control of the threshold voltage and noise margin of organic thin-film transistors and organic complementary circuits using mixed phosphonic acid self-assembled monolayer gate dielectrics (2009)

For many applications of organic thin-film transistors (TFTs), high-capacitance gate dielectrics that can be processed at low temperature are of interest. Several approaches exist, including vapor-deposited metal oxides, ultra-thin polymers, self-assembled nanodielectrics, and thin hybrid dielectrics based on alkyl phosphonic acid self-assembled monolayers (SAMs) on plasma-oxidized aluminum gates. None of these approaches, however, provides deterministic and continuous control of the threshold voltage. A few reports of low-voltage (¿5 V) organic complementary circuits with symmetric switching threshold and large noise margins exist, but the TFTs were not air-stable and had to be operated in an inert gas, which is not practical for real applications. Here we show how the threshold voltage of air-stable, low-voltage organic TFTs and the switching threshold and noise margin of air-stable, low-voltage, low-power organic complementary circuits can be reproducibly tuned over a wide range by using a mixed alkyl/fluoroalkyl phosphonic acid self-assembled monolayer (SAM) as a high-capacitance gate dielectric.
TCP Reno over Adaptive CSMA (2010)

An interesting distributed adaptive CSMA MAC protocol, called adaptive CSMA, was proposed recently to schedule any strictly feasible achievable rates inside the capacity region. Of particular interest is the fact that the adaptive CSMA can achieve a system utility arbitrarily close to that is achievable under a central scheduler. However, a specially designed transport-layer rate controller is needed for this result. An outstanding question is whether the widely-installed TCP Reno is compatible with adaptive CSMA and can achieve the same result. The answer to this question will determine how close to practical deployment adaptive CSMA is. Our answer is yes and no. First, we observe that running TCP Reno directly over adaptive CSMA results in severe starvation problems. Effectively, its performance is no better than that of TCP Reno over legacy CSMA (IEEE 802.11), and the potentials of adaptive CSMA cannot be realized. Fortunately, we find that multi-connection TCP Reno over adaptive CSMA with active queue management can materialize the advantages of adaptive CSMA. NS-2 simulations demonstrate that our solution can alleviate starvation and achieve fair and efficient rate allocation. Multi-connection TCP can be implemented at either application or transport layer. Application-layer implementation requires no kernel modification, making the solution readily deployable in networks running adaptive CSMA.
Improved Function After Deep Brain Stimulation for Chronic, Severe Traumatic Brain Injury (2015)

DBS, deep brain stimulationIC, internal capsuleMPAI-4, Mayo-Portland Adaptability Inventory-4NAcc, nucleus accumbensTBI, traumatic brain injury.
Surface Structure of Aerobically Oxidized Diamond Nanocrystals (2014)

We investigate the aerobic oxidation of high-pressure, high-temperature nanodiamonds (5-50 nm dimensions) using a combination of carbon and oxygen K-edge X-ray absorption, wavelength-dependent X-ray photoelectron, and vibrational spectroscopies. Oxidation at 575 °C for 2 h eliminates graphitic carbon contamination (>98%) and produces nanocrystals with hydroxyl functionalized surfaces as well as a minor component (<5%) of carboxylic anhydrides. The low graphitic carbon content and the high crystallinity of HPHT are evident from Raman spectra acquired using visible wavelength excitation (λ<sub>excit</sub> = 633 nm) as well as carbon K-edge X-ray absorption spectra where the signature of a core-hole exciton is observed. Both spectroscopic features are similar to those of chemical vapor deposited (CVD) diamond but differ significantly from the spectra of detonation nanodiamond. The importance of these findings to the functionalization of nanodiamond surfaces for biological labeling applications is discussed.
X‐ray Absorption Spectroscopy Studies of the Room‐Temperature Ferromagnetic Fe‐Doped 6H–BaTiO 3 (2014)

We investigated the effect of annealing temperature on magnetic properties of 2% and 10% Fe‐doped BaTiO 3 . To understand the possible structural differences between samples treated at different annealing temperatures, and to correlate them with the magnetic properties, several characterization techniques, such as X‐ray diffraction and X‐ray absorption spectroscopic methods ( XANES and EXAFS ) were employed. We found that the 2% Fe‐doped BaTiO 3 pseudocubic perovskite is paramagnetic regardless of the heat‐treatment conditions. Initially paramagnetic 10% Fe‐doped 6H–BaTiO 3 , treated at 1250°C, became ferromagnetic after additional annealing at higher temperature. We have crystalographically characterized the cation ordering processes in the 6H–BaTiO 3 that occurred during the high‐temperature annealing. The ferromagnetism that is induced in this stage is most probably associated with the observed diffusion processes but it extrinsic character still cannot be fully disregarded.
ChemInform Abstract: A New Indole Synthesis Promoted by Metal Triflates. (1987)

Abstract A new method for the synthesis of 4‐substituted indoles involves a reaction sequence that is shown for the example (I) → (III) → (IV) → (V).
Nitration of Aromatic Compounds (2006)

This chapter contains sections titled: Introduction Reaction mechanism Nitration of aromatic compounds using zeolites as catalysts Conclusions References
Supplementary Table 1 from Cancer-Associated Adipose Tissue Promotes Breast Cancer Progression by Paracrine Oncostatin M and Jak/STAT3 Signaling (2023)

&lt;p&gt;MUC: mucoid carcinoma, IDCA: invasive ductal carcinoma, LOB: lobular carcinoma, I-NST: invasive, non special type, Max diam: maximal diameter, ER: estrogen receptor, PR: progesterone receptor, Pos LN: positive lymph nodes, BMI: body mass index.&lt;/p&gt;
Improvements in GeTe-based Phase Change RF Switches (2018)

Recent progress in GeTe-based phase-change RF switch technology will be presented. Use of tungsten micro-heat-ers in the inline phase change switch (IPCS) processes has improved device performance and reliability. Finite element simulations of the melt/quench process in GeTe for a thermally activated independent tungsten thin film heating element will be shown. A small (0.33mm × 0.61mm) series-shunt single-pole double-throw (SPDT) switch based on 3rd generation IPCS technology was built and characterized. The SPDT switch exhibited less than 1 dB insertion loss in the DC-65GHz bandwidth. We also report measured data of a wide-band, DC-65GHz, monolithic 4-bit attenuator circuit using IPCS technology.
Cationic Zirconium Complexes that Contain Mesityl-Substituted Diamido/Donor Ligands. Decomposition via CH Activation and Its Influence on 1-Hexene Polymerization (2001)

The dialkyl complexes [MesNMe]ZrMeNp (2b) and [MesNMe]ZrNp2 ([MesNMe]2- = [(MesNCH2CH2)2NMe]2-; Np = CH2CMe3) were prepared and shown to have distorted trigonal bipyramidal structures in which the two amido groups occupy equatorial positions. The neopentyl group in 2b was found in the axial position. Compound 2b was found to convert to another species (2a) in a first-order manner with k = 1.68 × 10-3 min-1 at 20 °C and to reach an equilibrium with Keq = [2a]/[2b] = 0.43 in C6D6. Activation of [MesNMe]ZrMeNp with [Ph3C][B(C6F5)4] led to formation of unobservable {[MesNMe]ZrNp}[B(C6F5)4], which decomposed by CH activation of an ortho mesityl methyl group to give an inactive dimer of {[activ-MesNMe]Zr}[B(C6F5)4], or in the presence of dimethylaniline by β methyl elimination to give {[MesNMe]ZrMe(PhNMe2)}[B(C6F5)4]. {[MesNMe]ZrMe}[B(C6F5)4] also decomposes to give the dimer of {[activ-MesNMe]Zr}[B(C6F5)4] with kd = 6.0 × 10-5 s-1 at 20 °C. A dimethyl complex was prepared that contained a second “internal amine” donor, i.e., {[(MesNCH2CH2)2NCH2CH2NMesMe]ZrMe2. Upon activation of the dimethyl species with [Ph3C][B(C6F5)4], one of the (now six) ortho methyl groups was CH activated; the methyl cation was not observed. 1-Hexene was polymerized too rapidly by {[MesNMe]ZrMe}[B(C6F5)4] to follow readily by NMR methods, while polymerization by {[MesNMe]Zr(PhNMe2)Me}[B(C6F5)4] and {{[MesNMe]ZrMe}2(μ-Me)}[B(C6F5)4] was found to be retarded by dimethylaniline and [MesNMe]ZrMe2, respectively. The marked curvature of the log plot of the consumption of 1-hexene by {[MesNMe]Zr(PhNMe2)Me}[B(C6F5)4] could be modeled by assuming that intermediates in the polymerization process decompose by CH activation of a mesityl methyl group and are thereby removed from the system as propagating species.
Separate-Confinement-Heterostructure Multiple-Quantum-Well Laser Diodes (1993)

High-power 1.48 pn graded-index separate-con- finement-heterostructure multiple-quantum-well laser diodes (GRIN-SCH MQW LD's) have been investigated in terms of the beam divergence, threshold current, and differential quantum efficiency. A calculation predicts that narrow beam divergence perpendicular to the junction plane could be obtained by the use of small number of step quaternary layers with wide band- gap. Experimentally, at the same time, the threshold current increased due to the small optical confinement, although the beam divergence became small. We optimized the GRIN-SCH layers for a narrow and circular output beam with maintaining low threshold current. The full width at the half maximum (FWHM) of the far-field pattern in the horizontal direction was 20 and that in the ver- tical direction was 25. The maximum output power, as high as 208 mW, was achieved at a driving current of 1000 mA for a 1 mm long device with an antireflection and high-reflection (2%/95%) coated facets. Stable transverse mode operation was confirmed up to the maximum output power. Due to high-power operation with a stable narrow and circular beam, an ex- tremely high coupling efficiency of 89% and a record high out- put power from a single-mode fiber of 185 mW were obtained at 25°C.