gebhart/patrepeval huggingface dataset:
Theoretical Mechanistic Investigation into Metal-Free Alternating Copolymerization of CO2 and Epoxides: The Key Role of Triethylborane (2018)

The copolymerization of carbon dioxide (CO2) and epoxides has received much attention during the past decades for the production of aliphatic polycarbonates. Remarkably, the green synthesis of polycarbonates was recently demonstrated by copolymerization of CO2 with epoxides under metal-free conditions. In this work, the reaction mechanism of this highly selective polymerization was further investigated using DFT calculations. Four steps were studied: step I describes the epoxide ring-opening by the chloride anion in the presence of the Lewis acid triethylborane (TEB); step II is related to the subsequent insertion of CO2; step III corresponds to the alternating insertion of an epoxide facilitated by TEB; step IV is characterized by the leaving of TEB followed by a new round of polymerization. The high selectivity to form alternating polycarbonates and the suppression of backbiting and homopolymerization that respectively generate cyclic carbonates and polyethers were confirmed by the difference of energy barriers. The key role of TEB at every step was also elucidated. Our theoretical results support the proposed experimental outcomes and provide the fundamental mechanistic insights.
ELIXIR-EXCELERATE D6.3: Report describing a set of tools, pipelines and search engine for interrogation of marine metagenomic data. (2019)

● Pipelines expanded to increase scope of analysis, tools updated and tailoring of analysis to meet the demands of the Marine Metagenomics community. ● Analysis pipelines described in the Common Workflow Language (CWL) to enable reproducibility, facilitate comparisons and enhance development agility. ● Benchmark datasets generated for evaluating amplicon analyses across a range of biomes and 6 different marine shotgun metagenomics datasets developed. ● Cloud deployment of pipelines to increase compute capacity. ● New data analysis outputs that will feed the databases developed as part of this work package. ● Examples generated for federating searches across resource programmatic interfaces. ● Wide range of different training activities and material developed. ● Major interaction with Compute (WP4) and Interoperability (WP5) platforms in sharing problems and driving solutions (e.g. AAI and CWL, respectively)
Through-Hole Contactless Slipring System Based on Rotating Magnetic Field for Rotary Applications (2014)

Contactless slipring system based on inductive power transfer is a preferable alternative to mechanical slipring assemblies. They are designed to deliver required output power to a rotary shaft without direct electrical contacts. The current single or multiple-unit through-hole single-phase systems often have limited power transfer capability within a confined physical space; thus, they may not be able to meet the load requirement for certain applications such as wind power pitch control. This paper presents an integrated polyphase through-hole contactless slipring system by generating a rotating primary magnetic field coupled with balanced power pickups at the secondary side with zero mechanical driving torque on the shaft. A new index termed “mutual inductance per pole” is introduced to simplify the analysis of the mutually coupled polyphase system to a single-phase basis. Simulation and practical experiments have demonstrated that, with the same physical size, the proposed contactless slipring setup can transfer 55% more power compared with the existing single-phase counterpart.
End‐group modified retro‐inverso isomers of tripeptide oxytocin analogues: binding to neurophysin II and enhancement of its self‐association properties (1995)

The importance of peptide backbone structure in peptide/protein recognition events has been tested evaluating the binding properties of end-group modified retro-inverso isomers of MYF and LYF amides, tripeptides able to mimic oxytocin in binding neurophysin II and in potentiating its self-association. The isomers, topochemically related to their parent peptides, have been prepared respectively from all-D N-acetyl-FYM and N-acetyl-FYL amides via the Hofmann-type rearrangement mediated by iodobenzene bis-trifluoroacetate. Retro-inverso isomers recognised neurophysin II with similar affinity as the parent peptides, as determined by analytical affinity chromatography on columns prepared immobilising neurophysin II on preactivated supports. In addition, their effect on neurophysin II self-association was similar to the tripeptide oxytocin analogues, potentiating neurophysin II dimerization to the same extent, as evaluated by solid-phase binding assays on microtiter plates coated with neurophysin II. Recognition specificity of retro-inverso isomers was further demonstrated by their inhibitory effect on the interaction between neurophysin II and oxytocin tripeptide analogues. Results suggest that only the proper orientation of the alpha-amino group and of the side chains plays a dominant role in the binding of tripeptide analogues to neurophysin II and potentiation of its self-association, while the peptide backbone topology has little influence on the recognition process.
Fluorescence studies of polymer adsorption. 3. Adsorption of pyrene-end-labeled poly(ethylene glycol) on colloidal polystyrene particles (1989)

The adsorption of pyrene-end-labeled poly(ethy1ene glycol) (Py-PEG-Py) onto aqueous colloidal polystyrene (PS) particles is investigated by photostationary fluorescence, fluorescence decay, and photostationary fluorescence depolarization experiments. All of the spectroscopic observations on this system suggest the association of hydrophobic pyrene moieties with hydrophobic particles: (i) the complete disappearance of excimers accompanied by a slight wavelength shift to lower energy in the monomer emission spectrum, (ii) a significant red-shift of about 3.5 nm in the monomer excitation spectrum, (iii) an increase in the average lifetime of the fluorescence decay, and (iv) increased averaged anisotropy measured in fluorescence depolarization experiments of chromophores 1,6-diphenyl-l,3,5-hexatrien(eD PH) and pyrene upon addition of PS particles. This association with the surface contrasts with previous observations of Py-PEG-Py adsorbing on hydrophilic silica particles (Char, K.; Gast, A. P.; Frank, C. W. Langmuir 1988, 4, 989). Excitation spectra of pyrene groups at various particle concentrations are much more sensitive to their state of binding than emission spectra. Qualitative displacement experiments and studies of the effect of molecular weight of Py-PEG-Py both suggest that the binding of hydrophobic pyrene to the PS surface is stronger than that of PEG segments to the surface.
The Thirteen Colonies (2012)

Students will demonstrate understanding of similarities and differences between the Thirteen Colonies and their community today.
Complete proton and carbon spectral assignments of acrihellin and hellebrigenin (1991)

Abstract The complete assignment of all 1 H and 13 C NMR signals of acrihellin in chloroform solution is presented. The analysis of the 1 H and 13 C NMR spectra was performed using the heteronuclear 2D NMR techniques H,C‐COSY and H,C‐COLOC. For an unambiguous assignment of the 13 C NMR spectrum the elucidation of carbon–carbon connectivities via 2D‐INADEQUATE was most important. The INADEQUATE experiment was also applied to hellebrigenin in DMSO‐ d 6 solution. This experiment confirmed a recently published carbon assignment.
Polymerized Ionic Liquids: Solution Properties and Electrospinning (2009)

In this study, the solution properties and electrospinning of a polymerized ionic liquid was explored. Polymerized ionic liquids are synthesized from polymerizing ionic liquid monomers, where ionic liquids are of great interest due to their unique physiochemical properties. Compared to other polyelectrolyte solutions, this polymerized ionic liquid solution exhibits similar viscosity scaling relationships in the semidilute unentangled and semidilute entangled regimes. However, the electrospraying-electrospinning transition occurs at similar polymer solution concentrations compared to neutral polymers, where electrospinning produced beaded fibers and defect-free fibers at ∼1.25 and ∼2 times the entanglement concentration, respectively. Due to high solution conductivities, electrospinning produces fibers approximately an order of magnitude smaller than neutral polymers at equivalent normalized solution concentrations. In addition, a high ionic conductivity of the solid-state fiber mat was observed under dry conditions and even higher conductivities were observed for polyelectrolyte fiber mats produced from electrospinning polyelectrolyte−ionic liquid solutions, where both anion and cation are mobile species.
Placement of cuffed tunneled dual-lumen catheters for children treated with the long-term extracorporeal blood purification (2010)

カテーテルの出口部が下方を向く挿入・固定法だった1999年から2004年のA群 (6症例) と，カテーテルの出口部を耳介後部から垂直に上方に向けて挿入・固定した2005年から2009年のB群 (3症例) の2群に分け，当院で経験した15歳以下の症例に対する長期留置型バスキュラーアクセス (Vascular Access: VA) についてカテーテルトラブルの発生率・その内容・カテーテルの留置期間を中心に検討した。A群では1症例あたり平均37.7回，B群では21.3回の体外循環血液浄化療法 (Extracorporeal blood purification: EBP) が施行されていた。EBP施行期間の平均は，A群では87.5日間で，B群では61.0日間であった。A群では全例でEBPの中断を余儀なくされたのに対して，B群でのEBP中断症例は1例もなかった。B群では中断や入れ替えを必要とせずにEBPが可能であったことから，カテーテルの出口部を上方に向けて直線的に挿入・固定することで屈曲・閉塞を防ぎ，十分な血液流量を確保できたことがEBPの安全かつ確実な継続に繋がったと考えられた。
Trajectory-based observer for hybrid automata fault diagnosis (2015)

A method for constructing state observers for hybrid automata is proposed. The approach is trajectory-based. So it does not require the system to be fully observable. The discrete and continuous states of the system can be estimated constantly. We present implementation of the observer, and its application to fault diagnosis problem of hybrid automata.
Clinical practice guidelines for high-resolution breast PET, 2019 edition (2021)

Breast positron emission tomography (PET) has had insurance coverage when performed with conventional whole-body PET in Japan since 2013. Together with whole-body PET, accurate examination of breast cancer and diagnosis of metastatic disease are possible, and are expected to contribute significantly to its treatment planning. To facilitate a safer, smoother, and more appropriate examination, the Japanese Society of Nuclear Medicine published the first edition of practice guidelines for high-resolution breast PET in 2013. Subsequently, new types of breast PET have been developed and their clinical usefulness clarified. Therefore, the guidelines for breast PET were revised in 2019. This article updates readers as to what is new in the second edition. This edition supports two different types of breast PET depending on the placement of the detector: the opposite-type (positron emission mammography; PEM) and the ring-shaped type (dedicated breast PET; dbPET), providing an overview of these scanners and appropriate imaging methods, their clinical applications, and future prospects. The name "dedicated breast PET" from the first edition is widely used to refer to ring-shaped type breast PET. In this edition, "breast PET" has been defined as a term that refers to both opposite- and ring-shaped devices. Up-to-date breast PET practice guidelines would help provide useful information for evidence-based breast imaging.
Supplementary Figure 1 from Telomerase Peptide Vaccination in NSCLC: A Phase II Trial in Stage III Patients Vaccinated after Chemoradiotherapy and an 8-Year Update on a Phase I/II Trial (2023)

&lt;p&gt;PDF file - 2417KB&lt;/p&gt;
An Optimized Temporal Filter Implementation for Practical Applications (2022)

VVenC, an open and optimized VVC encoder implementation, employs a temporal filter from the literature as a pre-processing step. The filter effectively reduces camera noise from input video, thereby increasing the encoding gain for lossy encoding, at a price of fairly high complexity, further increased by the necessity of consistent application to many pictures. The filter represents one of the most runtime consuming processing steps for the fastest operating points of VVenC. In this paper, steps are described to reduce the complexity of the temporal filtering in VVenC, to allow its application with low-complexity presets. Overall, the filter runtime is reduced by a factor of around 17 compared to the state of the art, while slightly improving its performance. An additional 4 times speedup is achieved using vectorized implementation. In the proposed version, for the VVenC preset faster, the filter provides 7.36% BD-rate gain at only 2% runtime overhead.
Disease Pathways and Novel Therapeutic Targets in Hypertrophic Cardiomyopathy (2011)

As described in earlier reviews in this series on the molecular basis of hypertrophic cardiomyopathy (HCM), HCM is one of the archetypal monogenic cardiovascular disorders to be understood at the molecular level. Twenty years after the discovery of the first HCM disease gene, genetic studies still confirm that HCM is principally a disease of the sarcomere. At the biophysical level, myofilament mutations generally enhance Ca(2+) sensitivity, maximal force production, and ATPase activity. These defects ultimately appear to converge on energy deficiency and altered Ca(2+) handling as major common paths leading to the anatomic (hypertrophy, myofiber disarray, and fibrosis) and functional features (pathological signaling and diastolic dysfunction) characteristic of HCM. In this review, we provide an account of the consequences of HCM mutations and describe how specifically targeting these molecular features has already yielded early promise for novel therapies for HCM. Although substantial efforts are still required to understand the molecular link between HCM mutations and their clinical consequences, HCM endures as an exemplar of how novel insights derived from molecular characterization of Mendelian disorders can inform the understanding of biological processes and translate into rational therapies.
Administration of Voriconazole in Patients With Renal Dysfunction (2012)

Voriconazole route of administration and baseline renal function were not predictors of worsening renal dysfunction on days 3, 7, and EOT. Underlying disease, baseline liver impairment, and concomitant administration of other drugs (eg, penicillins, fluoroquinolones, immunosuppressants) were the strongest predictors of renal dysfunction.
Creating ensemble of diverse maximum entropy models (2012)

Diversity of a classifier ensemble has been shown to benefit overall classification performance. But most conventional methods of training ensembles offer no control on the extent of diversity and are meta-learners. We present a method for creating an ensemble of diverse maximum entropy (∂MaxEnt) models, which are popular in speech and language processing. We modify the objective function for conventional training of a MaxEnt model such that its output posterior distribution is diverse with respect to a reference model. Two diversity scores are explored - KL divergence and posterior cross-correlation. Experiments on the CoNLL-2003 Named Entity Recognition task and the IEMOCAP emotion recognition database show the benefits of a ∂MaxEnt ensemble.
A 3D Level Sets Method for Segmenting the Mouse Spleen and Follicles in Volumetric microCT Images (2006)

We present a semi-automatic, 3D approach for segmenting the mouse spleen, and its interior follicles, in volumetric microCT imagery. Based upon previous 2D level sets work, we develop a fully 3D implementation and provide the corresponding finite difference formulas. We incorporate statistical and proximity weighting schemes to improve segmentation performance. We also note an issue with the original algorithm and propose a solution that proves beneficial in our experiments. Experimental results are provided for artificial and real data.
Spin-Selective AC Stark Shifts in a Charged Quantum Dot (2019)

We demonstrate a spin-selective modification to the energy structure of a charged quantum dot using the AC Stark effect. This mechanism offers a potentially rapid, reversible, and coherent control of the energy structure.
Paste (2016)

We’ve built this digital research platform to provide academics everywhere with fast, stable and secure digital access to our library of over 110,000 scholarly books and 800,000 journal articles. We’ve tested the platform in close cooperation with leading academic institutions. If you have any questions or you notice something doesn’t quite work as it should, please visit our <a href="/publishing/faq?lang=en" class="text-primary">Help/FAQ</a> page and let us know.
Novel Signal Processing Method for Super-Resolution Discs (2007)

To improve signal quality of super-resolution discs, we propose a signal processing method to reduce the normal-resolution component. From the simulation results based on FDTD, bit error rate was reduced from 10−2 to under 10−4.
High-resolution structure of an HIV-1 quasispecies (1992)

Some of the myriad proviruses present in an individual harbour novel coding sequences. While these are probably of little importance for AIDS pathogenesis they emphasize the ability of HIV to explore a huge range of genetic configurations.
Polymer Modification of Fiber Optic Chemical Sensors as a Method of Enhancing Fluorescence Signal for pH Measurement (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolymer modification of fiber optic chemical sensors as a method of enhancing fluorescence signal for pH measurementChristiane Munkholm, David R. Walt, Fred P. Milanovich, and Stanley M. KlainerCite this: Anal. Chem. 1986, 58, 7, 1427–1430Publication Date (Print):June 1, 1986Publication History Published online22 September 2008Published inissue 1 June 1986https://pubs.acs.org/doi/10.1021/ac00298a034https://doi.org/10.1021/ac00298a034research-articleACS PublicationsRequest reuse permissionsArticle Views628Altmetric-Citations151LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis bioaerosols (2019)

Abstract The tuberculosis (TB) pandemic demands urgent interventions such as those designed to interrupt Mycobacterium tuberculosis ( Mtb ) transmission, a challenge exacerbated by our poor understanding of the events enabling successful transfer of infectious bacilli between hosts. To address this problem, we developed the Respiratory Aerosol Sampling Chamber (RASC), a personal clean-room equipped with high-efficiency filtration and sampling technologies that allow biosafe capture and isolation of particulate matter – including Mtb bacilli – released by patients during natural breathing and (non-induced) cough. Here, we demonstrate the use of DMN-trehalose labelling to detect and quantify live Mtb bacilli among complex bioaerosol samples arrayed in a bespoke nanowell device following capture in the RASC. A pilot study identified Mtb in more than 85 % of known TB patients, improving significantly on previous work which has relied on animal infection and cough sampling to estimate transmission events. Moreover, intra-patient comparisons of bioaerosol and sputum samples indicated that Mtb aerosols likely derive from a compartment other than sputum. These results support the utility of the RASC platform for research aimed at interrupting Mtb transmission, including the non-invasive detection of Mtb -infected individuals who are predicted to contribute to bacillary spread despite the absence of clinical symptoms.
New 2,6,9-trisubstituted adenines as adenosine receptor antagonists: a preliminary SAR profile (2007)

A new series of 2,6,9-trisubstituted adenines (5-14) have been prepared and evaluated in radioligand binding studies for their affinity at the human A(1), A(2A) and A(3) adenosine receptors and in adenylyl cyclase experiments for their potency at the human A(2B) subtype. From this preliminary study the conclusion can be drawn that introduction of bulky chains at the N (6) position of 9-propyladenine significantly increased binding affinity at the human A(1) and A(3) adenosine receptors, while the presence of a chlorine atom at the 2 position resulted in a not univocal effect, depending on the receptor subtype and/or on the substituent present in the N (6) position. However, in all cases, the presence in the 2 position of a chlorine atom favoured the interaction with the A(2A) subtype. These results demonstrated that, although the synthesized compounds were found to be quite inactive at the human A(2B) subtype, adenine is a useful template for further development of simplified adenosine receptor antagonists with distinct receptor selectivity profiles.
Efficient and stable photoelectrochemical energy conversion using p-type WSe2 photocathodes implications (2013)

We have synthesized highly cryst. p-type WSe2 and characterized its electrochem. and photoelectrochem. behavior in a variety of&#13;\naq. redox couples. Energy conversion efficiencies of &gt; 7% with respect to the thermodn. potential for hydrogen evolution have&#13;\nbeen achieved for p-WSe2 photocathodes deposited with a mixed Ru/Pt cocatalyst under 100 mW cm^(-2) white light illumination.&#13;\nAddnl., these photocathodes exhibit good stability during photoredn. of Me viologen for at least two hours under illumination at&#13;\npH values of 2 and 10. Spectral response measurements suggest that energy conversion efficiencies are limited by short&#13;\nminority-carrier diffusion lengths, but impedance spectroscopy indicates that the p-WSe2 band-edge positions are nearly ideal for&#13;\nattaining max. photovoltages for the hydrogen evolution reaction.
High activity catalysts for the total oxidation of naphthalene based on mesoporous ceria modified with low levels of copper (2012)

1 figure.-- Work presented at the 15th International Congress on Catalysis, ICC 2012, in Munich (Germany), July 1st-6th, 2012.