gebhart/patrepeval huggingface dataset:
RELATIONSHIPS WITH INDUSTRY (2006)

Jacobs, Joshua J. MD; Moderator; Galante, Jorge O. MD, DMSC; Mirza, Sohail K. MD, MPH; Zdeblick, Thomas MD Author Information
Interference Mitigation Using Spectrum Sensing (2007)

The concept of spectrum sensing is in the broad sense, the ability to detect and interpret other signals in the band and take appropriate actions by implementing adaptive techniques in the MAC layer in addition to traditional interference cancellation techniques applied in the PHY layer. In this paper we present algorithms to detect interference to WLAN systems in the 2.4GHz spectrum originating from microwave ovens or frequency hopping devices like cordless phone, and methods to mitigate the interference. The concept can be extended to other coexistence issues as well as spectrum sharing between primary and secondary users of a spectrum.
Novel approach for structure analysis by x-ray Raman scattering (1987)

An oscillation similar to that in extended x-ray absorption fine-structure (EXAFS) measurements was observed in the x-ray Raman spectra of graphite by exciting 8265-eV x rays from synchrotron radiation. From an analysis employing the formula used for EXAFS, the carbon-carbon interatomic distances are obtained which are in good agreement with the known values in graphite. Thus, x-ray Raman scattering by hard x rays is a very promising method for the determination of the local structure around light elements.
Event-Based Modeling with High-Dimensional Imaging Biomarkers for Estimating Spatial Progression of Dementia (2019)

Event-based models (EBM) are a class of disease progression models that can be used to estimate temporal ordering of neuropathological changes from cross-sectional data. Current EBMs only handle scalar biomarkers, such as regional volumes, as inputs. However, regional aggregates are a crude summary of the underlying high-resolution images, potentially limiting the accuracy of EBM. Therefore, we propose a novel method that exploits high-dimensional voxel-wise imaging biomarkers: n-dimensional discriminative EBM (nDEBM). nDEBM is based on an insight that mixture modeling, which is a key element of conventional EBMs, can be replaced by a more scalable semi-supervised support vector machine (SVM) approach. This SVM is used to estimate the degree of abnormality of each region which is then used to obtain subject-specific disease progression patterns. These patterns are in turn used for estimating the mean ordering by fitting a generalized Mallows model. In order to validate the biomarker ordering obtained using nDEBM, we also present a framework for Simulation of Imaging Biomarkers' Temporal Evolution (SImBioTE) that mimics neurodegeneration in brain regions. SImBioTE trains variational auto-encoders (VAE) in different brain regions independently to simulate images at varying stages of disease progression. We also validate nDEBM clinically using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). In both experiments, nDEBM using high-dimensional features gave better performance than state-of-the-art EBM methods using regional volume biomarkers. This suggests that nDEBM is a promising approach for disease progression modeling.
Photoluminescence and Scintillation Properties of SiO2 Glass Activated with Eu2+ (2015)

The basic photoluminescence and scintillation properties of Eu-doped SiO 2 glass are reported. When UV light was excited to the glass, an intense blue emission band was observed owing to the 4f 6 5d-4f 7 ( 8 S 7/2 ) transition of Eu 2+ emission centers. The fluorescence quantum efficiency (QE) and the decay time of Eu 2+ were calculated to be about 95% and 1230 ns, respectively. The 5d-4f emission band of Eu 2+ also appeared in the 450 nm wavelength range in the X-ray-excited radioluminescence spectrum. By 241 Am -ray-irradiated pulse height spectra, the relative scintillation light output was found to be about 110% compared with reference lithium silicate glass (GS20) scintillator.
GSTT1as a Prognosticator for Recurrence and Progression in Patients with Non-Muscle-Invasive Bladder Cancer (2010)

Although polymorphisms in glutathione S-transferase (GST) have been associated with the risk of bladder cancer (BC), few reports provide information about the development of BC. The aim of the present study was to investigate the effect of homozygous glutathione S-transferase-μ (GSTM1) and glutathione S-transferase-&amp;phis; (GSTT1) deletions as prognostic markers in non-muscle-invasive bladder cancer (NMIBC). A total of 241 patients with primary NMIBC were enrolled in this study. GSTM1 and GSTT1 polymorphisms were analyzed by multiplex polymerase chain reaction (PCR) using blood genomic DNA. The results were compared with clinicopathological parameters. The prognostic significance of the GSTs was evaluated by Kaplan-Meier and multivariate Cox regression model. A statistically significant association between genotype and histopathological parameter was not observed. The patients with the GSTT1-positive genotype had significantly reduced recurrence- and progression-free survival than those with the GSTT1-null genotype (log-rank test, p &lt; 0.05, respectively). Recurrenceand progressionfree survival were not related to the GSTM1 genotypes. In multivariate regression analysis, the GSTT1positive genotype was the independent predictor for recurrence [hazard ratio (HR), 1.631; p = 0.043] and progression (HR, 3.418; p = 0.006). These results suggested that the GSTT1 genotype could be a useful prognostic marker for recurrence and progression in NMIBC.
Carbon Nanofilaments in Heterogeneous Catalysis: An Industrial Application for New Carbon Materials? (2001)

Special carbon! Carbon nanofilaments differ from graphite and soot catalysts in their high stability during the oxidative dehydrogenation of ethylbenzene to styrene (see picture). The high yields of styrene achieved suggest that a first industrial application of carbon nanofilaments in catalysis is possible.
Tailoring re-entrant geometry in inverse colloidal monolayers to control surface wettability (2015)

Two-dimensional nanopore arrays with adjustable re-entrant curvature are prepared from colloidal templating and used to pattern low-surface-tension liquids.
Massive MU-MIMO Downlink TDD Systems with Linear Precoding and Downlink Pilots (2013)

We consider a massive MU-MIMO downlink time-division duplex system where a base station (BS) equipped with many antennas serves several single-antenna users in the same time-frequency resource. We assume that the BS uses linear precoding for the transmission. To reliably decode the signals transmitted from the BS, each user should have an estimate of its channel. In this work, we consider an efficient channel estimation scheme to acquire CSI at each user, called beamforming training scheme. With the beamforming training scheme, the BS precodes the pilot sequences and forwards to all users. Then, based on the received pilots, each user uses minimum mean-square error channel estimation to estimate the effective channel gains. The channel estimation overhead of this scheme does not depend on the number of BS antennas, and is only proportional to the number of users. We then derive a lower bound on the capacity for maximum-ratio transmission and zero-forcing precoding techniques which enables us to evaluate the spectral efficiency taking into account the spectral efficiency loss associated with the transmission of the downlink pilots. Comparing with previous work where each user uses only the statistical channel properties to decode the transmitted signals, we see that the proposed beamforming training scheme is preferable for moderate and low-mobility environments.
Low level light effects on inflammatory cytokine production by rheumatoid arthritis synoviocytes (2009)

The mechanism for relieving joint pain in RA by LLLT may involve reducing the level of pro-inflammatory cytokines/chemokines produced by synoviocytes. This mechanism may be more general and underlie the beneficial effects of LLLT on other inflammatory conditions.
Electrical Properties of the La<sub>2</sub>O<sub>3</sub>/4H-SiC Interface Prepared by Atomic Layer Deposition Using La(iPrCp)<sub>3</sub> and H<sub>2</sub>O (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Regular Expression Matching with Memristor TCAMs (2018)

Regular expression (RegEx)matching is a key function in network security, where matching of packet data against known malicious signatures filters and alerts against active network intrusions. RegExs are widely used in open source and commercial network security systems as they easily and concisely represent complex patterns like those malicious signatures. However, the latency and power required to perform RegEx matching is incredibly high and approaches to this problem struggle to achieve > 1 Gbps on real-world rulesets while internet wirespeeds continue to increase > 100 Gbps. We propose performing RegEx matching using memristor-based ternary content addressable memories (mTCAMs)with compressed finite automata (CFA)to meet this challenge. In this work, we show fabrication of mTCAM circuits with excellent device properties from 100nm to 20nm device sizes and validate mTCAM operation. SPICE simulations investigate mTCAM performance at scale and a mTCAM dynamic power model using 16 nm mTCAM layout parameters demonstrates 0.173 fJ/bit/search energy for a 36×250 mTCAM array. Using a tiled architecture to implement a Snort ruleset, we estimate performance of our mTCAM approach to be 47.2 Gbps at 1.21 W dynamic search power (39 Gbps/W), compared to a state-of-the-art FPGA approach which achieves 3.9 Gbps at 630 mW (6.2 Gbps/W). Preliminary error analysis shows the mTCAM approach allows for arbitrarily low false positive/negative rates using minimal and standard state refresh techniques. Dynamic search power is also calculated prior to applying standard TCAM power-reduction techniques capable of lowering power by ~ ×10, further demonstrating the promise of mTCAM for wirespeed RegEx matching at low power.
Click chemistry assembly of G-quadruplex ligands incorporating a diarylurea scaffold and triazole linkers (2008)

A series of diarylurea ligands were designed to interact selectively with G-quadruplexes and were synthesised using copper(I) catalysed 'click' chemistry to incorporate the 1,4-substituted 1,2,3-triazole ring into the core of the ligands; the optimal ligands demonstrate a high degree of selective telomeric G-quadruplex stabilisation and are not cytotoxic in several cancer cell lines.
Reaction of Acetals with Various Carbon Nucleophiles under Non‐Acidic Conditions: CC Bond Formation via a Pyridinium‐Type Salt (2011)

Mild substitution reactions of acetals with carbon nucleophiles via the pyridinium-type salts generated by the treatment of acetals with TESOTf-2,4,6-collidine or 2,2'-bipyridyl have been developed. Various carbon nucleophiles, such as organocuprates, silyl enol ethers, enamines, etc., reacted with the pyridinium-type salts to give the corresponding substituted products in good yields. The reactions proceeded under very mild conditions (non-acidic conditions) and thus acid-sensitive functional groups can be tolerated during the reaction. In addition, only an acetal can form the pyridinium-type salt and react with nucleophiles in the presence of a ketal. This unusual selectivity is in contrast to general methods conducted under acidic conditions.
Robustness of Synchronized Chaotic Oscillations (1997)

In this paper we address the issue of robustness of synchronized chaotic oscillations in coupled systems. One frequently observes in physical experiments that synchronized chaotic oscillations are occasionally interrupted by brief incidents of unsynchronized behavior. By numerical simulations we show that, under certain circumstances, the regime of synchronized chaos is very sensitive to even small noise and to slightest differences between parameters of coupled systems. As a result of such sensitivity, these small perturbations lead to non-steady, "bursting" synchronization. Using experiments with nonlinear electronic circuits and analytical and numeric analyzes of their ODE model, we study certain bifurcations associated with fixed points and limit cycles in the synchronized chaotic attractor. We establish the connection between these bifurcations and the appearance of the outbursts of unsynchronized behavior. We illustrate a mechanism of formation of complicated invariant sets of trajectories that are associated with the dynamics during such outbursts.
Mechanism and enhancement of anti-parasitic-reaction catalytic activity of tungsten-carbide-coated graphite components for the growth of bulk GaN crystals (2022)

Abstract The working mechanism of the anti-parasitic-reaction (APR) catalyst of tungsten carbide (WC) coating on graphite in hydride vapor phase epitaxy GaN growth were examined. During NH 3 annealing, the surface of WC is reduced as well as nitrided. The W 2 N topmost layer was found to work as an APR-active catalyst to suppress the formation of GaN polycrystals during high-rate HVPE-GaN growth, while the regions covered with thick pyrolytic graphite residues were catalytically inert. The formation of an additional W 2 C top layer on the WC underlayer was demonstrated to exhibit superior APR activity, i.e. complete suppression of GaN polycrystal formation.
128: High prevalence of bone loss in long term survivors following allogeneic bone marrow and peripheral blood stem cell transplantation (2007)

Bone loss (osteopenia/osteoporosis) is a complication following allogeneic stem cell transplantation (SCT). After written consent patients surviving more than three years post-transplant were enrolled in a long-term follow-up study (started in April 2005) which included an annual DEXA scan. Sixty-three patients (median age 35 years) received a fractionated total body irradiation (TBI) (12-13.6 Gy) based myeloablative SCT (MST) and 9 patients (median age 37 years) received a non-TBI non-myeloablative SCT (NST). Age of patients at transplantation ranged from 6 to 66 (median 35 years). The indication for SCT was CML (43), MDS (11), AML (11), ALL (3), CLL (2), SAA (1), and mastocytosis (1). Seventy-two (41M,31F) patients underwent DEXA scanning. Seventy (97%) patients are alive at a median follow-up of 73 months (range 32-155); Acute graft versus host disease (GVHD) occurred in 41 (57%) patients and chronic GVHD in 61 (85%). Twelve (17%) patients at a median follow up 37 (range 32-106 months) were receiving immunosuppressive therapy (IST) for chronic GVHD at the time of analysis. All patients were advised to take vitamin D and calcium supplements after transplantation and all but one female were taking hormone replacement therapy at the time of DEXA scanning. Fifty-three (74%) of patients had bone loss in at least one site measured - 30 (42%) with osteopenia and 23 (32%) with osteoporosis. There was a preponderance of osteopenia and osteoporosis in typical sites such as AP spine (22% and 18%); femoral neck (46% and 6%); and femur (Ward’s area) (38% and 8%); total hip (36% and 1%); but also in the forearm (24% and 13%) likely related to steriod therapy. Mean T score of adult patients was -1.8 ± 0.16 (male -1.9 ± 0.2; female -1.6 ± 0.3); while mean Z score of 5 children (age <18) was -1.6 ± 0.45. Factors associated with significant increase risk of bone loss were: age more than median (p=0.03) and prolonged IST (12/12 vs. 41/60; p=0.017 for bone loss and 8/12 vs.15/60; p=0.008 for osteoporosis). When patient age was analyzed by quartiles, the oldest quartile (range 44-66) was profoundly impacted for osteoporosis (mean T score -2.3 ± 0.25; p=0.016). There was no significant difference in bone loss with regard to sex, stem cell source, disease, TBI dose, acute GVHD, or chronic GVHD. In summary, we found a very high prevalence of bone loss in long term survivors of SCT. Bone loss is associated with older age at transplant and continuing treatment of chronic GVHD.
Contribución al encaminamiento óptimo en redes de circuitos virtuales con supervivencia mediante arquitecturas de memoria distribuida (1998)

El objetivo principal de esta tesis doctoral es el
desarrollo de nuevas tecnicas para encaminamiento optimo
en redes de circuitos virtuales con supervivencia, Este
tipo de problemas ha despertado gran interes en los
ultimos anos con la aparicion de redes de alta velocidad,
como puede ser el caso de ATM, con aplicacion en la RDSI
de banda ancha.

Las redes ATM son un ejemplo de redes con caminos
virtuales semipermanentes, por lo que se justifica el
desarrollo de algoritmos a priori que obtienen la
distribucion optima de dichos caminos y su capacidad.

Recientemente, se ha comenzado a introducir supervivencia
ante fallos en los modelos de caminos virtuales. Debido
al tamano y complejidad de los problemas que resultan,
los algoritmos tradicionales no pueden garantizar la
obtencion de una solucion sin un alto coste. Proponemos
un nuevo algoritmo orientado a arquitecturas paralelas,
que resulta ser superior a las alternativas existentes.
PD33-11 PROGRESSIVE MUSCLE CELL DELIVERY AS A SOLUTION FOR VOLUMETRIC MUSCLE DEFECT REPAIR (2018)

METHODS: We used a cryptorchid rat testes model of SSC disturbance. The model was generated using intra-abdominal injection of flutamide (7.5 mg/rat) into pregnant Sprague-Dawley rats. Normal testes, unilateral undescended testes (UDT), and contralateral descended testes (DT) were extirpated on postnatal day 9, when two types of SSCs (gonocytes and spermatogonia) co-existed and gonocytes began differentiation into spematogonia. A microarray examining DT and UDT focused on miR-135a, which exhibited lower expression in UDT. In situ hybridization (ISH) was used for the detection of the localization of miR-135a and quantitative polymerase chain reaction (qPCR) to determine the organ specificity of the gene. We then searched the miR-135a target genes using a computer program, followed by the luciferase assay to demonstrate the suppression effect of miR-135a in vitro.
Motexafi n gadolinium injection for the treatment of brain metastases in patients with non-small cell lung cancer (2007)

Despite recent advances in technology, targeting, and chemotherapy, brain metastasis from non-small cell lung cancer (NSCLC) remains a significant problem. The vast majority of patients with this diagnosis undergo whole brain radiation therapy (WBRT). However, outcomes are still quite poor with median survivals measured in only months. In an effort to enhance outcomes from external beam radiation treatments, radiosensitizers have been investigated. Motexafin gadolinium (MGd) (Xcytrin, Sunnyvale, CA, USA) is a novel radiation sensitizer with a unique mechanism of action that may increase the therapeutic index of WBRT for patients with brain metastases, particularly in those with NSCLC histologies. Here we review the rationale for the use of this drug as well as its current and future role as a radiation enhancer in the management of NSCLC brain metastasis.
Concentration recovery for SPECT CNS dopamine‐receptor studies for monkeys (1994)

Most commercial SPECT scanners do not properly compensate for scattering and partial volume effects, which severely impacts the quantitation of clinical and research SPECT studies, especially in CNS dopamine studies. Hence, in this paper, a brain phantom containing a monkey skull was used to calibrate a Picker Prism 3000 SPECT camera for quantitative studies of 123I and 99mTc-labeled radiopharmaceuticals. In the calibration study, two small vials representing basal ganglia were inserted into a skull phantom. A series of images were taken with different concentration ratios between the basal ganglia and the other brain compartments to simulate the dynamic imaging study of the dopamine D2 receptor in a monkey brain. Based on this calibration, a simple method is proposed for count correction in the region of interest (ROI). This technique is superior to using a single calibration factor from a cylindrical uniform activity phantom since it can compensate for both the partial volume effect and the dynamically changing effect of scattering. A significant difference between the true and measured values was observed in the correction factors (by a factor as much as 3). Furthermore, a cylindrical phantom, approximately the size of a monkey's head and containing the same basal ganglia inserts, was used to investigate the feasibility of using a cylindrical phantom with the proposed correction method. The results indicate that it is feasible to use a cylindrical phantom for the case where the activity inside the brain cavity and the activity in the surrounding tissue are similar.
Genomic and biochemical analysis of repeatedly observed variants in DBT in individuals with maple syrup urine disease of Central American ancestry (2022)

Maple syrup urine disease (MSUD) is an intoxication-type inherited metabolic disorder in which hyperleucinemia leads to brain swelling and death without treatment. MSUD is caused by branched-chain alpha-ketoacid dehydrogenase deficiency due to biallelic loss of the protein products from the genes BCKDHA, BCKDHB, or DBT, while a distinct but related condition is caused by loss of DLD. In this case series, eleven individuals with MSUD caused by two pathogenic variants in DBT are presented. All eleven individuals have a deletion of exon 2 (delEx2, NM_001918.3:c.48_171del); six individuals are homozygous and five individuals are compound heterozygous with a novel missense variant (NM_001918.5:c.916 T > C [p.Ser306Pro]) confirmed to be in trans. Western Blot indicates decreased amount of protein product in delEx2;c.916 T > C liver cells and absence of protein product in delEx2 homozygous hepatocytes. Ultrahigh performance liquid chromatography-tandem mass spectrometry demonstrates an accumulation of branched-chain amino acids and alpha-ketoacids in explanted hepatocytes. Individuals with these variants have a neonatal-onset, non-thiamine-responsive, classical form of MSUD. Strikingly, the entire cohort is derived from families who immigrated to the Washington, DC, metro area from Honduras or El Salvador suggesting the possibility of a founder effect.
Dietary administration of β-ionone epoxide to Sprague-Dawley rats for 90 days (2021)

In a 90-day GLP-compliant study groups of Sprague-Dawley rats (10/sex/group) were fed diets containing β-ionone epoxide, a fragrance material and a flavoring substance, at dietary concentrations providing target intakes of 0, 20, 40 and 80 mg/kg bw/day. There were no deaths and no adverse changes in clinical observations, ophthalmological examinations, body weight, body weight gain, food consumption, food efficiency; hematology, serum chemistry, urinalysis parameters; or in macroscopic findings attributable to β-ionone epoxide administration. Increased absolute and relative liver weights in high dose females without correlating hepatic histopathological findings were considered non-adverse. Cortical vacuolation of adrenal zona fasciculata was observed in high-dose males but was considered non-adverse due to the nondegenerative nature of this alteration. β-Ionone epoxide did not influence estrus cyclicity in females and did not affect sperm morphology or epididymal sperm count, homogenization-resistant spermatid count and motility measurements in male rats. The no-observed-adverse-effect level (NOAEL) for administration of β-ionone epoxide in the diet was determined to be the highest dose tested of 80 mg/kg bw/day.