gebhart/patrepeval huggingface dataset:
Myeloid-specific deletion of Zfp36 protects against insulin resistance and fatty liver in diet-induced obese mice (2018)

Obesity is associated with adipose tissue inflammation that contributes to insulin resistance. Zinc finger protein 36 (Zfp36) is an mRNA-binding protein that reduces inflammation by binding to cytokine transcripts and promoting their degradation. We hypothesized that myeloid-specific deficiency of Zfp36 would lead to increased adipose tissue inflammation and reduced insulin sensitivity in diet-induced obese mice. As expected, wild-type (Control) mice became obese and diabetic on a high-fat diet, and obese mice with myeloid-specific loss of Zfp36 [knockout (KO)] demonstrated increased adipose tissue and liver cytokine mRNA expression compared with Control mice. Unexpectedly, in glucose tolerance testing and hyperinsulinemic-euglycemic clamp studies, myeloid Zfp36 KO mice demonstrated improved insulin sensitivity compared with Control mice. Obese KO and Control mice had similar macrophage infiltration of the adipose depots and similar peripheral cytokine levels, but lean and obese KO mice demonstrated increased Kupffer cell (KC; the hepatic macrophage)-expressed Mac2 compared with lean Control mice. Insulin resistance in obese Control mice was associated with enhanced Zfp36 expression in KCs. Compared with Control mice, KO mice demonstrated increased hepatic mRNA expression of a multitude of classical (M1) inflammatory cytokines/chemokines, and this M1-inflammatory hepatic milieu was associated with enhanced nuclear localization of IKKβ and the p65 subunit of NF-κB. Our data confirm the important role of innate immune cells in regulating hepatic insulin sensitivity and lipid metabolism, challenge-prevailing models in which M1 inflammatory responses predict insulin resistance, and indicate that myeloid-expressed Zfp36 modulates the response to insulin in mice.
Evidence for “superfilling” of submicrometer trenches with electroless copper deposit (2007)

Void-free copper filling of trenches for ultralarge scale integrated interconnect structure was demonstrated by electroless deposition technique using polyethylene glycol as an inhibiting bath additive. With this electroless plating bath, the authors succeeded in demonstrating superfilling. Of particular interest is that the deposition at trench opening was nil during the filling process, while that at the bottom was very fast. This letter presents a demonstration and a proof of superfilling of trenches by electroless copper deposition.
Genome editing in the mouse brain with minimally immunogenic Cas9 RNPs (2023)

Abstract Transient delivery of CRISPR-Cas9 ribonucleoproteins (RNPs) into the central nervous system (CNS) for therapeutic genome editing could avoid limitations of viral vector-based delivery including cargo capacity, immunogenicity, and cost. Here we tested the ability of cell penetrant Cas9 RNPs to edit the mouse striatum when introduced using a convection enhanced delivery system. These transient Cas9 RNPs showed comparable editing of neurons and reduced adaptive immune responses relative to one formulation of Cas9 delivered using AAV serotype 9. The production of ultra-low-endotoxin Cas9 protein manufactured at scale further improved innate immunity. We conclude that injection-based delivery of minimally immunogenic CRISPR genome editing RNPs into the CNS provides a valuable alternative to virus-mediated genome editing.
Construction dynamique du sens : application à la prédication verbale (2010)

International audience
The defect structures and dissolution characteristics of iron filamentary single crystals / (1964)

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Supplementary Figures S1-S3 from Sequence-Specific Knockdown of EWS-FLI1 by Targeted, Nonviral Delivery of Small Interfering RNA Inhibits Tumor Growth in a Murine Model of Metastatic Ewing's Sarcoma (2023)

Supplementary Figures S1-S3 from Sequence-Specific Knockdown of EWS-FLI1 by Targeted, Nonviral Delivery of Small Interfering RNA Inhibits Tumor Growth in a Murine Model of Metastatic Ewing's Sarcoma
Preclinical experiment of auxiliary partial orthotopic liver transplantation as a curative treatment for hemophilia (2005)

The cause of hemophilia is deficiency of coagulation factor VIII production in the liver, which can be cured by liver transplantation. Because the hepatic function of hemophilia patients is quite normal except for production of factor VIII, auxiliary partial orthotopic liver transplantation (APOLT) is beneficial in that patient survival is secured by preserving native liver even in the event of graft loss. However, it is not known whether the graft of APOLT would be enough to cure hemophilia. We evaluated the efficacy and feasibility of APOLT for hemophilia in a canine hemophilia A model that we established. Partial left liver graft was taken from the normal donor (blood factor VIII activity > 60%). The graft was transplanted to the hemophilia beagle dog (blood factor VIII activity < 5%) after resection of the left lobe preserving native right lobe. Changes in time of blood factor VIII activity and liver function parameters were observed after APOLT. APOLT and perioperative hemostatic management were successfully performed. The blood factor VIII activity increased to 30% after APOLT, and was sustained at least 6 weeks throughout the observation period without symptoms of bleeding. The result demonstrated sustained production of factor VIII in the hemophilia recipient after APOLT. Transplantation of approximately one third of whole liver resulted in cure of hemophilia. In conclusion, it is suggested that APOLT would be feasible as a curative treatment of hemophilia A to improve quality of life of the patients.
Evaluation of In vitro synergistic and toxicity effects of Chromolaena odorata L. extracts with antibiotics (2022)

Natural products in this case the weed shrub Chromolaenaodorata or Siam weed is investigated for its antibiotic effects in vitro. The methanolic extract alone has demonstrated the most antibacterial effect towards S. aureus and S. pyogene. Interestingly, synergistic antimicrobial effect in combination withmethanolic extract using tetracycline and ciprofloxacin was found in both Gram-positive and Gram-negative bacteria namely S. pyogene, and Klebsiella spp. for tetracycline (3.98 ± 0.24 cm; 2.61 ± 0.12 cm) and for Ciprofloxacin, S. aureus, S. pyogene, E. coli (3.28 ± 0.16 cm; 3.79 ± 0.07 cm; 4.37 ± 0.10 cm; p<0.05). Phytochemical screening revealed positive results for carbohydrate, protein, alkaloid, flavonoid and tannin as main constituents in C. odorata. It may seem that this weed may contain potent natural compounds for alternative antibiotic treatment or formulation as surface or sub-cutaneous creams.
The Structure and Use of the GMR Combined Thermo-Mechanical Tire Power Loss Model (1981)

&lt;div class="htmlview paragraph"&gt;The operational structure and use of the “General Motors Research Laboratories Combined Thermo-Mechanical Tire Power Loss Model” are presented in this paper. The modular format of this tire power loss model is briefly reviewed. Descriptions of its three major analysis modules -- thermal, dissipation, and deformation -- are given. A flow chart is presented showing how these modules are interfaced to form an interactive, iterative model. Steps required to operate this model, procedures necessary to obtain and prepare the input data, and sample results obtained using the model are presented.&lt;/div&gt;
Hierarchical Multi-Objective Deep Reinforcement Learning for Packet Duplication in Multi-Connectivity for URLLC (2021)

In this paper, machine learning solutions have been investigated to improve the decision of packet duplication in a multi-connectivity cellular network to optimize the satisfaction of delay and reliability in 5G. A multi-agent deep reinforcement learning scheme with sequential actor-critic model has been developed to improve the decision of packet duplication from observations of radio environment including channel state, interference and load. A multi-objective reward function has been developed to minimize the transmission delay, error rate and maximize satisfaction of the URLLC targets. System-level simulations have been carried out in a heterogeneous network by utilizing dual connectivity between macro and small cells. Our deep reinforcement learning scheme is shown to prioritize packet duplication to the UE where it gains from lower queueing and interference. Comparing with standard 5G multi-connectivity, it reduces the overall packet error rate and delay, with increased satisfaction rate of URLLC targets. Furthermore, it improves the network throughput and resource efficiency in dynamic user traffic with lower redundancy.
Minimal Maximum-Level Programming—Combined Cell Mapping and Coding for Faster MLC Memory (2016)

In multi-level-cell memory, such as flash and phase-change memory, shrinking cell size and the growing number of levels per cell worsen the access rate to capacity ratio and even reduce access rate. We present minimal maximum-level programming, a scheme for expediting cell programming by sharing physical cells among multiple data sectors and exploiting the fact that making moderate changes to a cell's charge level is faster than making large ones. In particular, we encode the data such that in the k th writing of data to a cell, only the lowest k+1 levels are utilized. Unlike in previously proposed cell-sharing schemes, different same-size data sectors occupy different numbers of physical cells, and a cell may hold a fraction of a bit of a given data sector. Nevertheless, the exposed sector size remains unchanged. Data are encoded, but without redundancy. In a four-level cell example, we achieve up to 75% reduction in write latency. Read latency may be degraded, depending on the percentage of utilized capacity.
Mid-IR polarimetry: new vistas for SOFIA (2007)

Mid-infrared polarimetry remains an underexploited technique; where available it is limited in spectral coverage from the ground, and conspicuously absent from both the Spitzer and JWST instrument suites. The unique characteristics of SOFIA affords unprecedented spectral coverage and sensitivity in the mid-infrared waveband, offering new vistas in the exploration of astrophysical objects, including (a) galaxies and AGN, (b) star formation regions and (c) debris disks. Furthering the existing 5-40&mu;m imaging and spectroscopic capabilities of SOFIA, and the University of Florida's mid-IR imagers, spectrometer and polarimeter designs of T-ReCS and CanariCam, we present an overview of science highlights that could be performed from a ~5-40&mu;m imaging- and spectro-polarimeter on SOFIA. A secondary science driver is the inclusion of low- to moderate- resolution (total flux) spectroscopy at these wavelengths. Such an instrument concept would plug an unfilled area of both SOFIA and space-based instrumentation, providing SOFIA with unique and exciting science capabilities.
Autonomous optimization of nonaqueous battery electrolytes via robotic experimentation and machine learning (2021)

In this work, we introduce a novel workflow that couples robotics to machine-learning for efficient optimization of a non-aqueous battery electrolyte. A custom-built automated experiment named "Clio" is coupled to Dragonfly - a Bayesian optimization-based experiment planner. Clio autonomously optimizes electrolyte conductivity over a single-salt, ternary solvent design space. Using this workflow, we identify 6 fast-charging electrolytes in 2 work-days and 42 experiments (compared with 60 days using exhaustive search of the 1000 possible candidates, or 6 days assuming only 10% of candidates are evaluated). Our method finds the highest reported conductivity electrolyte in a design space heavily explored by previous literature, converging on a high-conductivity mixture that demonstrates subtle electrolyte chemical physics.
Informing air–carbon ablation modeling with theoretical calculations of atomic oxygen and nitrogen interacting with carbon surfaces (2023)

To understand the gas-surface chemistry above the thermal protection system of a hypersonic vehicle, it is necessary to map out the kinetics of key elementary reaction steps. In this work, extensive periodic density functional theory (DFT) calculations are performed to elucidate the interaction of atomic oxygen and nitrogen with both the basal plane and edge sites of highly oriented pyrolytic graphite (HOPG). Reaction energies and barriers are determined for adsorption, desorption, diffusion, recombination, and several reactions. These DFT results are compared with the most recent finite-rate model for air-carbon ablation. Our DFT results corroborated some of the parameters used in the model but suggest that further refinement may be necessary for others. The calculations reported here will help to establish a predictive kinetic model for the complex reaction network present under hypersonic flight conditions.
Uplink Design of Millimeter-Wave Mobile Communication Systems for High-Speed Trains (2014)

Passengers in a high-speed train (350 km/h) experience very poor multimedia services and discontinuous connections due to the much more and simultaneous handovers in the cellular networks. To handle these problems, a millimeter-wave mobile communication system for high-speed trains was introduced and its downlink structure was presented. This paper proposes the uplink structure appropriate to the millimeter-wave mobile communication system. It also describes the frame structure, the multiple access method, and the pilot deployment of the uplink channel. Especially, the uplink pilot was designed to solve the Doppler problem in order to achieve a higher spectrum efficiency. The simulation results of the uplink channel show the spectral efficiency of 4.18 bps/Hz even in 400 km/h under the Rician fading channel conditions.
MGMT: Immunohistochemical Detection in High-Grade Astrocytomas (2018)

Glioma therapeutic resistance to alkylating chemotherapy is mediated via O6-methylguanine-DNA methyltransferase (MGMT). We hypothesized that a CD45/HAM56/MGMT double-stained cocktail would improve MGMT discrimination in tumor cells versus inflammatory and endothelial cells (IEC). Total MGMT protein was quantified by IHC on 982 glioblastomas (GBM) and 199 anaplastic astrocytomas. Correcting for IEC was done by a CD45/HAM56/MGMT 2-color cocktail. Lowest IEC infiltrates (IEC "cold spots") were identified to quantitate MGMT as well as the percentage of IEC% in the IEC cold spots. MGMT promoter methylation (PM) was also determined. Among the GBM biopsies, mean uncorrected and corrected MGMT% were 19.87 (range 0-90) and 16.67; mean IEC% was 18.65 (range 1-80). Four hundred and fifty one (45.9%) GBM biopsies were positive MGMT PM. Both uncorrected and corrected MGMT% positivity correlated with PM. All 3 MGMT scores correlated with overall survival (OS) in GBM's. Cold spot IEC% was also positively associated with OS. These effects remained in a multivariate model after adjusting for age and disease status. Prognosis determined by correcting MGMT% score for IEC% is not improved in this analysis. However, IEC COLD SPOT score does provide additional prognostic information that can be gained from this correction method.
Dielectric properties, leakage behaviour, and resistance degradation of thin films of the solid solution series Ba(Ti1-yZry)O3 (1997)

Abstract Barium titanate zirconate thin films were grown on Pt-coated Si-substrates by a chemical solution deposition (CSD) method at temperatures of 750°C. The crystal structure and the morphology of these films with respect to the Ti/Zr ratio were studied by means of glancing incidence X-ray diffraction analysis, scanning and transmission electron microscopy. The dielectric properties were analyzed as a function of the composition and the applied electric field. Using transient impedance analysis, the dielectric relaxation, leakage, and resistance degradation of the thin films were investigated with respect to the Ti/Zr ratio. The measurements show that thin films of the composition Ba(Ti0.7Zr0.3)O3 exhibit an improved DRAM charge storage behaviour compared to the pure BaTiO3 films.
ChemInform Abstract: Synthesis of Isomelamines and Isocyanurates and Their Biological Evaluation. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A novel bidirectional DC-DC converter with high power efficiency for isolation in high voltage DC power feeding systems (2011)

Recently, the high voltage DC feeding system has been researched and developed to save electrical energy and to make use of the green energy from the solar cell, wind turbine and so forth. This paper presents a novel high efficiency DC-DC converter for isolation in high voltage DC feeding systems. The prototype 4.0kW bidirectional DC-DC converter has been made and tested. As a result, in the forward and regenerative operation modes, the maximum power efficiency over is 98.4% and the regulation degree of the output voltage is within 2% under the output power condition from 0.1kW to 4.0kW.
DARPA’s RASCAL: Status, Challenges, and Accomplishments (2004)

In March 2002, the Defense Advanced Research Projects Agency (DARPA) initiated the Rapid Access Small Cargo Affordable Launch (RASCAL) program and established the goal of creating a launch system capable of responsively and routinely placing small payloads into orbit at significantly reduced cost. RASCAL is a highly responsive, economical launch system capable of placing a 150 kg payload into an easterly low-Earth-orbit at a recurring cost below $10,000/kg. The RASCAL system consists of a reusable aircraft as the launch platform for a two-stage expendable rocket vehicle (ERV). A significant feature of the RASCAL aircraft is the ability for exo-atmospheric flight using a propulsion enhancement known as Mass Injection Pre-Compressor Cooling, or MIPCC. As we approach the end of Phase II in the fall of 2004, a design configuration update and discussion of major technological challenges and successes is provided. Specific discussions of system performance and risk mitigation testing are included.
Independence and interdependence of the photoregulation of pigmentation and development inFremyella diplosiphon (2010)

Many photosynthetic organisms exhibit light-dependent regulation of growth and development, including photoregulation of pigmentation, physiology, and form. We recently demonstrated that the photoregulation of cellular and filament morphology in Fremyella diplosiphon is under control of a photosensory photoreceptor and differentially impacted by photosynthetic pigment accumulation. Biliprotein photoreceptor RcaE controls the light-dependent regulation of pigmentation and of cell and filament morphology in F. diplosiphon, primarily in response to green and red light as a part of a light acclimation process known as complementary chromatic adaptation (CCA). Our recent investigations into the regulation of CCA underscored the largely independent regulation of pigmentation and cell shape by RcaE. However, recent studies on the regulation of phycobiliprotein biosynthesis indicated that filament length may depend upon correct photoregulation of photosynthetic pigment levels. Taken together, these studies suggest that aspects of the regulation of morphology in F. diplosiphon are independent of the regulation of pigmentation, yet other features of morphology depend upon the accurate photoregulation of pigment levels.
Functional expression of olfactory receptors in human primary melanoma and melanoma metastasis (2017)

We identified the olfactory receptor 51E2 in human melanoma and have measured both OR51E2 mRNA and protein expression in melanoma tissue sections. qPCR analysis revealed that the receptor is upregulated in melanoma cells compared to normal melanocytes, indicating that OR51E2 may play a role in early melanoma development and progression. Activation of endogenous OR51E2 in cultured cells derived from metastatic and vertical-growth phase (VGP) by its ligand β-ionone results in an increase in the intracellular Ca<sup>2+</sup> concentration. RNAi experiments showed that the β-ionone-induced Ca<sup>2+</sup> signal depends on the activation of OR51E2. Furthermore, OR51E2 activation inhibits the growth of VGP melanoma cells via apoptotic processes. Cell motility assays revealed that treatment with β-ionone decreases the migration of VGP melanoma cells. Overall, our data demonstrates that OR51E2 is involved in the regulation of cell proliferation and migration, suggesting that it may serve as a novel target for melanoma therapy.
CD73 Is Expressed by Human Regulatory T Helper Cells and Suppresses Proinflammatory Cytokine Production andHelicobacter felis–Induced Gastritis in Mice (2009)

CD39 and CD73 expressed by Th cells contribute to local accumulation of adenosine and attenuation of gastritis, which may favor persistent infection.
AN MRI STUDY IN SCHIZOPHRENIA: RELATIONSHIPS WITH STRUCTURAL IMAGING, EVOKED POTENTIALS AND NEUROPSYCHOLOGICAL TEST RESULTS (1992)

BLACKWOOD, D. H.R.*; YOUNG, A. H.*; MUIR, W. J.*; ROXBOROUGH, H. M.*; MCQUEEN, J. K.**; WALKER, M. T.* Author Information
Mildronate, a Novel Fatty Acid Oxidation Inhibitor and Antianginal Agent, Reduces Myocardial Infarct Size Without Affecting Hemodynamics (2006)

Mildronate is a fatty acid oxidation inhibitor approved as an antianginal drug in parts of Europe. We carried out the first study to determine whether a 10-day course of mildronate could reduce myocardial infarct size (IS) during acute myocardial ischemia. Sprague Dawley rats received 200 mg/kg/d of mildronate (treated group, n = 16) or sterile water (control group, n = 14) subcutaneously for 10 days before ischemia-reperfusion. Rats were then subjected to 45 minutes of left coronary artery occlusion and 2 hours of reperfusion. The 2 groups had identical areas at risk: treated 38 +/- 3%; controls 38 +/- 2%. The amount of necrosis was smaller in the mildronate group at 16 +/- 2% of the left ventricle versus controls, 22 +/- 2% (P = 0.05); and for any amount of risk >25%, necrosis was smaller in the treated group (P = 0.0035). Myocardial IS (% of risk zone) was 43+/-3% in the mildronate-treated rats, and 57+/-4% in controls (P = 0.004). During occlusion, there were no differences between the 2 groups in heart rate (216 +/- 12 bpm, mildronate and 210 +/- 9 bpm, control), in mean arterial pressure (60 +/- 2 mm Hg, mildronate and 64 +/- 3 mm Hg, control) or in the frequency of arrhythmias. Our study for the first time demonstrated that a 10-day treatment with mildronate reduced myocardial IS in an experimental model of acute myocardial ischemia, without any effect on hemodynamics.