gebhart/patrepeval huggingface dataset:
Infrared surface plasmons on heavily doped silicon (2011)

Conductors with infrared plasma frequencies are potentially useful hosts of surface plasmon polaritons (SPP) with sub-wavelength mode confinement for sensing applications. A challenge is to identify such a conductor that also has sharp SPP excitation resonances and the capability to be functionalized for biosensor applications. In this paper we present experimental and theoretical investigations of IR SPPs on doped silicon and their excitation resonances on doped-silicon gratings. The measured complex permittivity spectra for p-type silicon with carrier concentration 6×1019 and 1×1020 cm−3 show that these materials should support SPPs beyond 11 and 6 μm wavelengths, respectively. The permittivity spectra were used to calculate SPP mode heights above the silicon surface and SPP propagation lengths. Reasonable merit criteria applied to these quantities suggest that only the heaviest doped material has sensor potential, and then mainly within the wavelength range 6 to 10 μm. Photon-to-plasmon coupling resonances, a necessary condition for sensing, were demonstrated near 10 μm wavelength for this material. The shape and position of these resonances agree well with simple analytic calculations based on the theory of Hessel and Oliner (1965).
Calibration of Distributed Acoustic Sensing (DAS) VSP Data (2016)

Summary The usefulness of distributed acoustic sensing (DAS) VSP data to map reservoir structures and extract rock properties is limited only by our understanding of the fidelity and characteristics of the measurement. In order to calibrate both the kinematics and dynamics of DAS VSP products, we document the correspondence of the DAS and geophones measurements for extracted slowness values, corridor stacks, amplitudes, linearity with source effort, and response to incident angle. The DAS slowness values match very well with the corresponding geophone slowness and up-scaled sonic log. The arrival times and amplitudes of the corridor stacks show a very good agreement. The average earth attenuation extracted from the first break amplitudes are nearly identical for the DAS (Q=86) and geophone (Q=88) data sets. Tests varying the source effort confirm that the DAS measurement performs linearly with seismic amplitude. We also confirm the cosine squared response of the fiber to the incident angle of the seismic wave field. These tests show that properly acquired DAS VSP data sets can be trusted for both travel times and amplitude information.
Bioresorbable Vesicles Formed through Spontaneous Self-Assembly of Amphiphilic Poly(ethylene oxide)-block-polycaprolactone (2006)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTBioresorbable Vesicles Formed through Spontaneous Self-Assembly of Amphiphilic Poly(ethylene oxide)-block-polycaprolactoneP. Peter Ghoroghchian, Guizhi Li, Dalia H. Levine, Kevin P. Davis, Frank S. Bates, Daniel A. Hammer, and Michael J. TherienView Author Information School of Engineering and Applied Science, and Institute for Medicine and Engineering, University of Pennsylvania, 120 Hayden Hall, 3320 Smith Walk, Philadelphia, Pennsylvania 19104; Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104; and Department of Chemical Engineering and Materials Science, University of Minnesota, 151 Amundson Hall, 421 Washington Avenue SE, Minneapolis, Minnesota 55455 Cite this: Macromolecules 2006, 39, 5, 1673–1675Publication Date (Web):February 7, 2006Publication History Received31 August 2005Revised10 January 2006Published online7 February 2006Published inissue 1 March 2006https://pubs.acs.org/doi/10.1021/ma0519009https://doi.org/10.1021/ma0519009rapid-communicationACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views3089Altmetric-Citations245LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Drug delivery,Drug release,Membranes,Polymers,Vesicles Get e-Alerts
Sleep-promoting effects of endogenous pyrogen (interleukin-1) (1984)

When infused into the lateral cerebral ventricles of rabbits, human endogenous pyrogen (EP) preparations induced dose-dependent increases in slow-wave sleep concomitant with increasing body temperature. Heating EP to 70 degrees C destroyed its sleep-promoting and pyrogenic activity. Anisomycin (an antipyretic) prevented EP from increasing body temperature without affecting its sleep-promoting activity. Intravenous injection of EP induced fever and transient increases in slow-wave sleep but failed to induce prolonged increases in slow-wave sleep. We conclude that the somnogenic activity of EP is not secondary to its pyrogenic activity.
Complexity Reduction in Joint Decoding of Block Coded Signals in Overloaded MIMO-OFDM System (2014)

This paper presents a low complexity joint decoding scheme of block coded signals in an overloaded multiple-input multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) system. In previous literature, a joint maximum likelihood decoding scheme of block coded signals has been evaluated through theoretical analysis. The diversity gain with block coding prevents the performance degradation induced by signal multiplexing. However, the computational complexity of the joint decoding scheme increases exponentially with the number of multiplexed signal streams. Thus, this paper proposes a two step joint decoding scheme for block coded signals. The first step of the proposed scheme calculates metrics to reduce the number of the candidate codewords using decoding based on joint maximum likelihood symbol detection. The second step of the proposed scheme carries out joint decoding on the reduced candidate codewords. It is shown that the proposed scheme reduces the complexity by about 1/174 for 4 signal stream transmission.
Mirror-induced reflection in the frequency domain (2022)

Mirrors are ubiquitous in optics and are used to control the propagation of optical signals in space. Here we propose and demonstrate frequency domain mirrors that provide reflections of the optical energy in a frequency synthetic dimension, using electro-optic modulation. First, we theoretically explore the concept of frequency mirrors with the investigation of propagation loss, and reflectivity in the frequency domain. Next, we explore the mirror formed through polarization mode-splitting in a thin-film lithium niobate micro-resonator. By exciting the Bloch waves of the synthetic frequency crystal with different wave vectors, we show various states formed by the interference between forward propagating and reflected waves. Finally, we expand on this idea, and generate tunable frequency mirrors as well as demonstrate trapped states formed by these mirrors using coupled lithium niobate micro-resonators. The ability to control the flow of light in the frequency domain could enable a wide range of applications, including the study of random walks, boson sampling, frequency comb sources, optical computation, and topological photonics. Furthermore, demonstration of optical elements such as cavities, lasers, and photonic crystals in the frequency domain, may be possible.
Molecular basis of cross-reactivity among allergen-specific human T cells: T-cell receptor V alpha gene usage and epitope structure. (1994)

Cross-reactivities between the major grass pollen allergens, at the level of T-cell recognition was examined employing several Lolium perenne I (Lol p I)-specific human T-cell clones. Nine of these Lol p I-specific T-cell clones exhibited cross-recognition of the recombinant Poa pratensis IX (Poa p IX) allergen, rKBG7.2, indicating that these two major antigens of a grass pollen share T-cell epitopes. Furthermore, proliferative responses of two other T-cell clones demonstrated that individual allergens of diverse grass pollens also possess common T-cell epitopes. Examination of the T-cell receptor (TcR) V alpha genes of these T-cell clones indicated that these cloned cells utilized distinct J alpha genes and that nine out of 10 clones possessed V alpha 13 gene. Furthermore, sequence comparisons of several allergenic molecules indicated that this cross-reactivity may be due to the presence of epitope(s) with structure(s) similar to the major T-cell epitope of Poa p IX allergens. Taken together, these results suggest for the first time that the major grass pollen allergens share cross-reacting T-cell epitope(s), and that this cross-reactivity is due to the structural homologies among allergens and restricted usage of TcR V alpha genes.
Autoantibodies against type I IFNs in patients with life-threatening COVID-19 (2020)

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
Modeling requirements for transmission lines in multi-gigabit systems (2005)

As computer clock speeds continue to increase at a rate dictated by Moore's Law, the system buses must also scale in proportion to the processor speed. As data rates approach 8 to 10 Gb/s, the traditional methods used to model transmission lines start to break down and become inadequate for the proper prediction of signal integrity. Specifically, the approximations made in traditional transmission line models, while perfectly adequate for slower speeds, violate conservation of energy principles and produce non-causal waveforms in the time domain responses. This work is discuss the problems associated with accurately predicting transient responses at multi-gigabit data rates and provide a simple and practical solution that accurately predicts transient responses for multi-gigabit channel design.
Progressive Geometric View Factors for Radiative Thermal Simulation (2020)

International audience
Difference in beta 2-microglobulin removal between cellulosic and synthetic polymer membrane dialyzers. (1991)

Several kinds of dialyzers, with highly permeable membranes (HPM), have been designed to specifically remove beta 2-microglobulin (BMG). To clarify their solute transport characteristics, nine types of HPM dialyzers were evaluated during in vivo and in vitro studies using human plasma and aqueous solutions. No BMG membrane adsorption and/or plugging was seen with cellulosic membrane dialyzers during in vitro experiments using human plasma. On the other hand, all synthetic polymer membrane dialyzers had adsorptive properties, and in a dialyzer with a polymethylmethacrylate membrane, a large amount of BMG was removed by adsorption alone. Dialyzers with cellulose triacetate and polyacrylonitril membranes showed higher values of BMG diffusive dialysance (greater than 20 ml/min) and sieving coefficient (greater than 0.9). From in vitro experiments using an aqueous solution containing several solutes with relatively small or middle molecular weights, all HPM dialyzers had a higher overall mass transfer coefficient than any conventional membrane dialyzer.
Optical Pulse Storage, Shaping, and Wavelength Conversion in Resonators With Controllable Input Coupling (2009)

By controlling the coupling coefficient into a small optical resonator, the energy of an incoming pulse can be completely captured and stored within the cavity. This paper describes the conditions for complete energy capture and shows that this transfer is relatively robust to various deviations from ideal conditions. Once captured inside the optical resonator, the energy can be released with an arbitrary delay and pulse shape by again controlling the resonator coupling coefficient. In addition, the wavelength of the output pulse can be shifted through the use of an internal cavity-phase modulator. Applications of these effects will be important in the design of future optical storage and buffering devices.
Regulation of Secreted Protein Acidic and Rich in Cysteine during Adipose Conversion and Adipose Tissue Hyperplasia (2006)

SPARC expression correlated with adipose tissue hyperplasia and adipogenesis. Therefore, SPARC seems to play a role in adipose tissue physiology as it is involved in growth and differentiation.
Electronic Dispersion Pre-compensation using a Directly Modulated Laser at 10.7-Gb/s (2011)

A novel electronic dispersion pre-compensation scheme for a directly modulated laser at 10.7-Gb/s is described and experimentally demonstrated for 202 km transmission with a required OSNR of 20.3 dB at a bit error ratio of 10−3.
Fine functional organization of auditory cortex revealed by Fourier optical imaging (2005)

We provide an overall view of the functional tonotopic organization of the auditory cortex in the rat. We apply a recently developed technique for acquiring intrinsic signal optical maps, Fourier imaging, in the rat auditory cortex. These highly detailed maps, derived in a several-minute-long recording procedure, delineate multiple auditory cortical areas and demonstrate their shapes, sizes, and tonotopic order. Beyond the primary auditory cortex, there are at least three distinct areas with fine-scale tonotopic organization, as well as at least one additional high-frequency field. The arrangement of all of these cortical areas is consistent across subjects. The accuracy of these optical maps was confirmed by microelectrode mapping in the same subjects. This imaging method allows fast mapping of the auditory cortex at high spatial resolution comparable to that provided by conventional microelectrode technique. Although spiking activity is largely responsible for the evoked intrinsic signals, certain features of the optical signal cannot be explained by spiking activity only, and should probably be attributed to other mechanisms inducing metabolic activity, such as subthreshold membrane phenomena.
Simulation of the suspension structure for the improvement of colloidal processes (2015)

International audience
A single ascending dose study of single‐stranded oligodeoxyribonucleotide RO7062931 in Chinese healthy volunteers (2023)

RO7062931 is an N-acetylgalactosamine (GalNAc)-conjugated single-stranded oligodeoxyribonucleotide complementary to hepatitis B virus RNA. GalNAc conjugation targets the liver through the asialoglycoprotein receptor (ASGPR). This phase I single ascending dose (SAD) study evaluated the safety, tolerability, and pharmacokinetics of RO7062931 in Chinese healthy volunteers. There were four SAD cohorts (0.3, 1.0, 2.0, and 4.0 mg/kg), in each of which healthy volunteers were randomized to a single subcutaneous (s.c.) injection of RO7062931 or matching placebo in a 4:1 ratio. Placebo recipients were pooled as one treatment group for safety assessments. A total of 41 healthy Chinese men received one dose of RO7062931 (n = 33) or placebo (n = 8) and completed the study (85-day follow-up). Adverse events (AEs) were reported in 22 of 33 (66.6%) RO7062931 recipients (n = 80 treatment-related) and seven of eight (87.5%) placebo recipients (n = 1 treatment-related). Apart from two moderate-intensity AEs, all AEs were mild. The most frequently reported AEs were influenza, injection-related reactions, and headache. Dose-proportional increases in plasma RO7062931 exposure were observed between the 0.3 and 1.0 mg/kg doses, whereas a supra-dose-proportional increase occurred at doses greater than or equal to 2.0 mg/kg, along with a marked increase in urinary excretion. Single s.c. dose of RO7062931 up to 4.0 mg/kg were safe and well-tolerated in healthy Chinese volunteers. Pharmacokinetic data suggested that ASGPR saturation had commenced between doses of 2.0 and 4.0 mg/kg. Results were broadly consistent with observations in primarily White subjects in the global first-in-human study of RO7062931.
AUDIO ANALOGIES: CREATING NEW MUSIC FROM AN EXISTING PERFORMANCE BY CONCATENATIVE SYNTHESIS (2005)

This paper describes a method for creating new music by concatenative synthesis. Given a MIDI score and an audio recording of an example piece of monophonic music, our method synthesizes audio to correspond with a new MIDI score. The algorithm we use is based on concatenative synthesis, commonly used for generating speech. Two versions of our algorithm are explored, one in which individual notes from the example piece are concatenated, and one in which pairs of adjacent notes from the example piece are concatenated. We examine the range of example pieces and target scores for which each version of our algorithm yields good results. Our underlying framework remains general enough to be applicable to other problems, such as rendering a stylized version of the target score, and other types of sound analogies. 1.
Matrix Pencil Method: Angle of Arrival and Channel Estimation for a Massive MIMO system (2020)

Channel estimation is essential in massive MIMO systems. Pilot Contamination (PC) however, causes a major bottleneck in the acquisition of this information. The exploitation of the Angle of Arrival (AoA) provides multiple techniques for channel estimation under PC. However, many AoA estimation techniques require information on the signal statistics which is not available in dynamic scenarios. In this paper we propose and analyse the Matrix Pencil Method (MPM) to decorrelate contaminated channels based on their estimated AoA. We evaluate this method both through simulations and experiments in a real-life testbed. Our assessment focuses on a system with a Uniform Linear Array (ULA). The performance of the MPM is validated through simulations <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> with varying number of antennas, SNR and AoA difference. The results show that our approach effectively decorrelates the channels starting from 20 antennas and an SNR of 15 dB, which outperforms the theoretical expectation. This allows us to enhance the channel estimation quality under PC to the level of no PC. Real-life measurements confirm the simulated results. Our MPM implementation can achieve a target AoA estimation accuracy both with and without PC. We anticipate that the method can be extended for a Uniform Rectangular Array (URA). <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> We would like to thank NVIDIA for providing the GPU that was used to greatly accelerate our simulations.
Rashba spin-orbit interaction in a MgxZn1−xO/ZnO two-dimensional electron gas studied by electrically detected electron spin resonance (2013)

We report the experimental determination of Rashba spin-orbit interaction (SOI) strength in two-dimensional electrons in a MgZnO/ZnO heterostructure using electrically detected electron spin resonance. The Rashba parameter is determined to be $7.0\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}14}$ eV m, which is the second smallest value among prevalent semiconductor heterostructures, following Si/SiGe. A long transverse spin relaxation time was derived to show a maximum value of 27 ns, owing to weak SOI. Our study demonstrates that the ZnO heterostructure is a promising candidate for spintronic devices utilizing long spin coherence.
Stacking-layer-number dependence of highly stacked InAs quantum dot laser diodes fabricated using strain-compensation technique (2012)

Semiconductor quantum dots (QDs) grown using self-assembly techniques in the Stranski- Krastanov (S-K) mode are expected to be useful for high-performance optical devices such as QD lasers. A significant amount of research has been carried out on the development of highperformance QD lasers because they offer the advantages of a low threshold current, temperature stability, high modulation bandwidth, and low chirp. To realize these high-performance devices, the surface QD density should be increased by fabricating a stacked structure. We have developed a growth method based on a strain-compensation technique that enables the fabrication of a high number of stacked InAs QD layers on an InP(311)B substrate. In this study, we employed the proposed method to fabricate QD laser diodes consisting of highly stacked QD layers and investigated the dependence of the diode parameters on the stacking layer number. We fabricated QD laser diodes with 5, 10, 15, and 20 QD layers in the active region. All of the laser diodes operated at around 1.55 &mu;m at room temperature, and their threshold currents showed clear dependence on the stacking layer number. Laser diodes with more than 10 QD layers showed sufficient gain, i.e., the threshold currents decreased with a decrease in the cavity length. On the other hand, for laser diodes with less than 10 QD layers, the threshold currents increased with a decrease in the cavity length.
Mapping the idiotopes of a monoclonal anti-myoglobin antibody with syngeneic monoclonal anti-idiotypic antibodies: detection of a common idiotope. (1986)

A panel of syngeneic monoclonal anti-idiotypic antibodies was prepared by immunizing A.SW mice with keyhole limpet hemocyanin-coupled A.SW monoclonal anti-myoglobin (HAL 19, IgG1) and screening the cloned hybridomas for production of IgG2 binding to idiotype but not to certain other anti-myoglobin antibodies of the same subclass in an ELISA. With these antibodies, we identified three nonoverlapping idiotopes, based on three clusters of monoclonal anti-idiotopes that mutually inhibit within each cluster, but not between clusters (Cluster I: S2, S6, S8; Cluster II: S5, S7; Cluster III: S9). Only Cluster II antibodies block the binding of myoglobin to HAL 19 and so identify a binding site-related idiotope(s). Binding of both Cluster II monoclonals (S5 and S7) to Hal 19 is inhibited by a rabbit anti-idiotype that we previously reported detects a common cross-reactive anti-myoglobin idiotope in immune sera. However, only one of these, S7, and not S5, identifies an idiotope that is present on 20 to 30% of A.SW anti-myoglobin antibodies in immune sera and ascites. The panel of syngeneic monoclonal anti-idiotype antibodies also detects new idiotopes not detected by the rabbit anti-idiotype. The development of a panel of syngeneic monoclonal anti-idiotypic antibodies to different clusters of idiotopes on the same antibody molecule, including one that identifies a major common idiotope in immune sera, should allow the analysis of possible idiotype network regulation in vivo and in vitro in a completely syngeneic system.