PD10-12 PROGNOSTIC SIGNIFICANCE OF THE PROPORTION OF DUCTAL COMPONENT IN DUCTAL ADENOCARCINOMA OF THE PROSTATE (2017)

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy I1 Apr 2017PD10-12 PROGNOSTIC SIGNIFICANCE OF THE PROPORTION OF DUCTAL COMPONENT IN DUCTAL ADENOCARCINOMA OF THE PROSTATE Won Sik Jang, Myung Soo Kim, Jae Won Park, Jong Soo Lee, Jong Won Kim, Jae Yong Jeong, Sung Ku Kang, Young Sig Kim, In Rae Cho, and Young Deuk Choi Won Sik JangWon Sik Jang More articles by this author , Myung Soo KimMyung Soo Kim More articles by this author , Jae Won ParkJae Won Park More articles by this author , Jong Soo LeeJong Soo Lee More articles by this author , Jong Won KimJong Won Kim More articles by this author , Jae Yong JeongJae Yong Jeong More articles by this author , Sung Ku KangSung Ku Kang More articles by this author , Young Sig KimYoung Sig Kim More articles by this author , In Rae ChoIn Rae Cho More articles by this author , and Young Deuk ChoiYoung Deuk Choi More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.575AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES In prostate cancer, ductal adenocarcinoma is mixed with usual acinar adenocarcinoma. However, whether the proportion of ductal component affects oncologic outcomes is currently unknown. Here, we investigated whether the proportion of the ductal component predicts oncologic outcomes in ductal adenocarcinoma. METHODS We retrospectively reviewed clinical data from 3,038 patients with prostate cancer who underwent radical prostatectomy at our institution between 2005 and 2014. We excluded patients who received neoadjuvant or adjuvant treatment. Patients were stratified based on the proportion of the ductal component. We compared the probability of biochemical recurrence between groups and investigated how the proportion of the ductal component influences biochemical recurrence using Kaplan-Meier estimates and Cox regression models, respectively. RESULTS Of 2,648 patients, 101 (3.8%) had ductal adenocarcinoma and 2,547 (96.2%) had acinar adenocarcinoma. Biochemical recurrence-free survival for patients with ductal adenocarcinoma was significantly lower compared with those with acinar adenocarcinoma (p<0.001). When ductal cases were stratified by the proportion of the ductal component, biochemical recurrence-free survival for the high ductal component (≥ 30%) group was significantly lower compared that of the low ductal component (< 30%) group (p = 0.023). In univariate and multivariate Cox regression analyses, a high ductal component was a significant predictor of biochemical recurrence (hazard ratio 2.508, 95% confidence interval 1.133-5.552, p = 0.023). CONCLUSIONS The prognosis for ductal adenocarcinoma can be stratified by the proportion of the ductal component. This marker could potentially be used as a surrogate for poor prognosis or as a determinant for adjuvant therapy. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e204-e205 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Won Sik Jang More articles by this author Myung Soo Kim More articles by this author Jae Won Park More articles by this author Jong Soo Lee More articles by this author Jong Won Kim More articles by this author Jae Yong Jeong More articles by this author Sung Ku Kang More articles by this author Young Sig Kim More articles by this author In Rae Cho More articles by this author Young Deuk Choi More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...