gebhart/patrepeval huggingface dataset:
Testudo: Collaborative Intelligence for Latency-Critical Autonomous Systems (2022)

Edge computing is to be widely adopted for autonomous systems (ASs) applications as compute-intensive processing tasks can be offloaded to compute-capable servers located at the edge of the network infrastructure. Given the critical nature of numerous AS applications, their tasks are mostly governed by strict execution deadlines to alleviate any safety concerns from delayed responses. Although wireless link uncertainty has prompted recent works to designate redundant local execution as an offloading fail-safe to ensure these deadlines are met, frequent invocation of such fail-safe mechanisms can potentially undermine the extent of performance gains from offloading. In this article, we thoroughly analyze how redundant execution overheads can influence the overall performance. Then, we present TESTUDO, a methodology to optimize the energy consumption for latency-sensitive AS applications employing collaborative edge computing. Primarily, our methodology encompasses two main stages: 1) designing processing pipelines supporting optimal offloading points and fail-safe integration using modular design techniques and 2) developing a context-aware adaptive runtime solution based on deep reinforcement learning to adapt the mode of operation according to the wireless network status. Our experiments for end-to-end control and object detection use-cases have shown that TESTUDO achieved energy gains reaching up to 31% and 13.4% (15.9% and 5.3% on average) for the former and latter, respectively, while incurring little-to-no degradation in prediction scores (< 1% change) from state-of-the-art strategies.
Paper-Based Electrochemical Detection of Chlorate (2018)

We describe the use of a paper-based probe impregnated with a vanadium-containing polyoxometalate anion, [PMo<sub>11</sub>VO<sub>40</sub>]<sup>5-</sup>, on screen-printed carbon electrodes for the electrochemical determination of chlorate. Cyclic voltammetry (CV) and chronocoulometry were used to characterize the ClO₃<sup>-</sup> response in a pH = 2.5 solution of 100 mM sodium acetate. A linear CV current response was observed between 0.156 and 1.25 mg/mL with a detection limit of 0.083 mg/mL (S/N > 3). This performance was reproducible using [PMo<sub>11</sub>VO<sub>40</sub>]<sup>5-</sup>-impregnated filter paper stored under ambient conditions for as long as 8 months prior to use. At high concentration of chlorate, an additional catalytic cathodic peak was seen in the reverse scan of the CVs, which was digitally simulated using a simple model. For chronocoulometry, the charge measured after 5 min gave a linear response from 0.625 to 2.5 mg/mL with a detection limit of 0.31 mg/mL (S/N > 3). In addition, the slope of charge vs. time also gave a linear response. In this case the linear range was from 0.312 to 2.5 mg/mL with a detection limit of 0.15 mg/mL (S/N > 3). Simple assays were conducted using three types of soil, and recovery measurements reported.
Pancam Multispectral Imaging Results from the Opportunity Rover at Meridiani Planum (2004)

Panoramic Camera (Pancam) images from Meridiani Planum reveal a low-albedo, generally flat, and relatively rock-free surface. Within and around impact craters and fractures, laminated outcrop rocks with higher albedo are observed. Fine-grained materials include dark sand, bright ferric iron-rich dust, angular rock clasts, and millimeter-size spheroidal granules that are eroding out of the laminated rocks. Spectra of sand, clasts, and one dark plains rock are consistent with mafic silicates such as pyroxene and olivine. Spectra of both the spherules and the laminated outcrop materials indicate the presence of crystalline ferric oxides or oxyhydroxides. Atmospheric observations show a steady decline in dust opacity during the mission. Astronomical observations captured solar transits by Phobos and Deimos and time-lapse observations of sunsets.
Mapping the Distinctive Populations of Lymphatic Endothelial Cells in Different Zones of Human Lymph Nodes (2014)

The lymphatic sinuses in human lymph nodes (LNs) are crucial to LN function yet their structure remains poorly defined. Much of our current knowledge of lymphatic sinuses derives from rodent models, however human LNs differ substantially in their sinus structure, most notably due to the presence of trabeculae and trabecular lymphatic sinuses that rodent LNs lack. Lymphatic sinuses are bounded and traversed by lymphatic endothelial cells (LECs). A better understanding of LECs in human LNs is likely to improve our understanding of the regulation of cell trafficking within LNs, now an important therapeutic target, as well as disease processes that involve lymphatic sinuses. We therefore sought to map all the LECs within human LNs using multicolor immunofluorescence microscopy to visualize the distribution of a range of putative markers. PROX1 was the only marker that uniquely identified the LECs lining and traversing all the sinuses in human LNs. In contrast, LYVE1 and STAB2 were only expressed by LECs in the paracortical and medullary sinuses in the vast majority of LNs studied, whilst the subcapsular and trabecular sinuses lacked these molecules. These data highlight the existence of at least two distinctive populations of LECs within human LNs. Of the other LEC markers, we confirmed VEGFR3 was not specific for LECs, and CD144 and CD31 stained both LECs and blood vascular endothelial cells (BECs); in contrast, CD59 and CD105 stained BECs but not LECs. We also showed that antigen-presenting cells (APCs) in the sinuses could be clearly distinguished from LECs by their expression of CD169, and their lack of expression of PROX1 and STAB2, or endothelial markers such as CD144. However, both LECs and sinus APCs were stained with DCN46, an antibody commonly used to detect CD209.
Observation of discrete time-crystalline order in a disordered dipolar many-body system (2016)

Understanding quantum dynamics away from equilibrium is an outstanding challenge in the modern physical sciences. It is well known that out-of-equilibrium systems can display a rich array of phenomena, ranging from self-organized synchronization to dynamical phase transitions. More recently, advances in the controlled manipulation of isolated many-body systems have enabled detailed studies of non-equilibrium phases in strongly interacting quantum matter. As a particularly striking example, the interplay of periodic driving, disorder, and strong interactions has recently been predicted to result in exotic "time-crystalline" phases, which spontaneously break the discrete time-translation symmetry of the underlying drive. Here, we report the experimental observation of such discrete time-crystalline order in a driven, disordered ensemble of $\sim 10^6$ dipolar spin impurities in diamond at room-temperature. We observe long-lived temporal correlations at integer multiples of the fundamental driving period, experimentally identify the phase boundary and find that the temporal order is protected by strong interactions; this order is remarkably stable against perturbations, even in the presence of slow thermalization. Our work opens the door to exploring dynamical phases of matter and controlling interacting, disordered many-body systems.
Rethinking ‘responsibility’ in precision agriculture innovation: lessons from an interdisciplinary research team (2023)

We examine the interactions, decisions, and evaluations of an interdisciplinary team of researchers tasked with developing an artificial intelligence-based agricultural decision support system that can provide farmers site-specific information about managing nutrients on their land. We answer the following research questions: (1) How does a relational perspective help an interdisciplinary team conceptualize ‘responsibility' in a project that develops precision agriculture (PA)? and (2) What are some lessons for a research team embarking on a similar interdisciplinary technology development project? We show that how RI is materialized in practice within an interdisciplinary research team can produce different understandings of responsibility, notions of measurement of ‘matter,’ and metrics of success. Future interdisciplinary projects should (1) create mechanisms for project members to see how power and privilege are exercised in the design of new technology and (2) harness social sciences as a bridge between natural sciences and engineering for organic and equitable collaborations.
Falling-Film Evaporation on Tube Bundle with Plain and Enhanced Tubes—Part I: Experimental Results (2010)

The complexities of two-phase flow and falling-film evaporation on a tube bundle present important challenges in the design of heat exchangers and the understanding of the physical phenomena taking place. The development of structured surfaces to enhance nucleate boiling heat transfer and, thus, reduce the size of evaporators adds another level of complexity, requiring the characterization of the effect of enhanced surfaces on the boiling phenomena occurring in a falling-film evaporator. In this article, falling-film evaporation measurements on a single tube row bundle and a three-row tube bundle were performed to obtain local heat transfer coefficients. Four types of tubes were tested: a plain tube, an enhanced condensing tube (Gewa-C+LW, Wieland Werke, Ulm, Germany)and two enhanced boiling tubes (Turbo-EDE2, Wolverine, Hunstville, Alabama, USA; Gewa-B4, Wieland Werke, Ulm, Germany). Two refrigerants, R134a and R236fa, were tested at a saturation temperature of 5 degrees C, liquid film Reynolds numbers ranging from 0 to 3,000, and heat fluxes between 20 and 60 kW/m(2) in pool boiling and falling-film configurations. Finally, the understanding of the physical phenomena governing the falling-film evaporation of liquid refrigerants has been investigated with visualization of the process.
Surface electronic structure of nitrogen-doped semiconducting single-walled carbon nanotube networks (2013)

We investigated the effects of vacuum annealing on the surface electronic structure and the work function of single-walled carbon nanotubes (SWCNTs). We changed the doping type of semiconducting single-walled carbon nanotubes (semi-SWCNTs) from p-type to n-type, and investigated their optical properties. The HNO3 treated p-type SWCNT network was converted to n-type after vacuum annealing due to formation of C-N bond. The C 1s sp2 binding energy of the vacuum annealed semi-SWCNTs was shifted toward a higher binding energy about 0.42 eV, which indicates a raising Fermi level as much as 0.42 eV compared with the intrinsic semi-SWCNTs. In addition, the work function of the vacuum annealed semi-SWCNT was observed towards lower energies. It is considered that the C-N bonding of semi-SWCNTs creates a donor level near the bottom of the conduction band, thus raising the Fermi level. The ultraviolet photoelectron spectroscopy and X-ray photoelectron spectroscopy revealed that the increased binding energy of C 1s sp2 and the decreased work function of semi-SWCNTs are caused by n-type doping after vacuum annealing.
Inhibition of T-cell responsiveness during experimental infections with Trypanosoma brucei: active involvement of endogenous gamma interferon (1993)

Lymph node cells (LNC) from mice infected with Trypanosoma brucei contain macrophage-like cells that inhibit interleukin-2 receptor (IL-2R) expression (M. Sileghem, A. Darji, R. Hamers, M. Van De Winkel, and P. De Baetselier, Eur. J. Immunol. 19:829-835, 1989). Evidence that gamma interferon (IFN-gamma) is actively involved in (i) the inhibition of IL-2R expression and (ii) the generation of suppressive cells during infections with T. brucei is presented. First, despite an impaired T-cell mitogenic response, LNC from infected mice are hyperresponsive for IFN-gamma production. Second, addition of neutralizing anti-IFN-gamma antibodies to cocultures of normal LNC and suppressive LNC populations reduces the level of suppression and restores the level of IL-2R expression. Third, administration of anti-IFN-gamma to T. brucei-infected animals increases the blastogenic response and reduces the suppressive activity of LNC.
Large‐scale eigenvalue calculations for stability analysis of steady flows on massively parallel computers (2001)

Abstract This paper presents an approach for determining the linear stability of steady states of partial differential equations (PDEs) on massively parallel computers. Linearizing the transient behavior around a steady state solution leads to an eigenvalue problem. The eigenvalues with the largest real part are calculated using Arnoldi's iteration driven by a novel implementation of the Cayley transformation. The Cayley transformation requires the solution of a linear system at each Arnoldi iteration. This is done iteratively so that the algorithm scales with problem size. A representative model problem of three‐dimensional incompressible flow and heat transfer in a rotating disk reactor is used to analyze the effect of algorithmic parameters on the performance of the eigenvalue algorithm. Successful calculations of leading eigenvalues for matrix systems of order up to 4 million were performed, identifying the critical Grashof number for a Hopf bifurcation. Copyright © 2001 John Wiley &amp; Sons, Ltd.
[Development of Mandarin tonal identification in noise test materials]. (2014)

The mandarin tonal identification materials were designed by both the tonal acoustic properties and the psychophysics characteristic of adults. It is an useful speech test in clinical work and research, and can potentially be used as the basic list for other tonal language identification test in the future.
Empirical approach to robust gramian-based analysis of process interactions in control structure selection (2011)

This paper deals with the estimation of a gramian-based interaction measure from logged process data, and thereby removing the need of creating parametric models prior to the selection of the significant input-output interconnections. Moreover, the resulting confidence regions of the estimates can be used to perform a robust control structure selection. The considered interaction measure is the Participation Matrix. Based on previous results, a new unbiased statistic is proposed, and confidence bounds for the estimate are derived. Examples and a case study are used to illustrate how the method can be applied.
Identification of tissue specific nuclear proteins: DNA sequence and protein binding regions in the T cell receptor beta J-C intron (1990)

We have determined the DNA sequences in the J2-C2 intron of the T cell receptor (TCR) beta gene and analyzed nuclear proteins binding to this region. Previously, we identified two tissue-specific DNase I hypersensitive regions, potential regulatory regions, in the J-C intron. The DNA sequence of the J2-C2 intron revealed that both DNase I hypersensitive regions have similar DNA sequences, suggesting that these regions are evolutionarily conserved. We have also identified tissue-specific nuclear-protein binding regions downstream of the DNase hypersensitive regions. Although transcriptional enhancer activity was not observed in the hypersensitive regions or the adjacent protein binding regions in the J-C intron, our findings suggest that the TCR-beta J-C intron may contain some other type of regulatory element.
Experimental Validation of Process-Induced Variability Aware SPICE Simulation Platform for Sub-20 nm FinFET Technologies (2021)

We propose an experimentally validated physics-based process-induced variability (PIV) aware SPICE simulation framework-enabling the estimation of performance variation due to line-edge-roughness (LER), metal-gate-granularity (MGG), random-dopant-fluctuation (RDF), and oxide-thickness-variation (OTV) at sub-20 nm technology node devices. The framework utilizes LER, RDF, OTV, and MGG defining parameters such as fin-edge correlation coefficient (ρ), autocorrelation length (Λ), grain-size (GS), σ[EOT], etc. as the inputs, and produces I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> -V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> distribution of ensemble size 250 as an output. We have validated the framework against 14 nm FinFET experimental data for I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> -V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> trends as well as for the threshold-voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> ), ON-current (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> ), and subthreshold slope (SS) distributions for a range of device dimensions with a reasonably good match. The worst and the best case R square errors are 0.64 and 0.98, respectively, for the validation. The very nature of the proposed framework allows the designers to use it for a vast range of process technologies. Such models are of dual importance, as it enables a PIV aware prediction of circuit-level performance, and provides a platform to estimate PIV parameters efficiently, on-par with sophisticated structural characterization tools.
Tradeoff Between Delay and High SNR Capacity in Quantized MIMO Systems (2019)

Analog-to-digital converters (ADCs) are a major contributor to the power consumption of multiple-input multiple-output (MIMO) communication systems with large number of antennas. Use of low resolution ADCs has been proposed as a means to decrease power consumption in MIMO receivers. However, reducing the ADC resolution leads to performance loss in terms of achievable transmission rates. In order to mitigate the rate-loss, the receiver can perform analog processing of the received signals before quantization. Prior works consider one-shot analog processing where at each channel-use, analog linear combinations of the received signals are fed to a set of one-bit threshold ADCs. In this paper, a receiver architecture is proposed which uses a sequence of delay elements to allow for blockwise linear combining of the received analog signals. In the high signal to noise ratio regime, it is shown that the proposed architecture achieves the maximum achievable transmission rate given a fixed number of one-bit ADCs. Furthermore, a tradeoff between transmission rate and the number of delay elements is identified which quantifies the increase in maximum achievable rate as the number of delay elements is increased.
Trellis-based Scalar-vector quantizer for memoryless sources (1993)

The paper describes a structured vector quantization approach for stationary memoryless sources that combines the scalar-vector quantizer (SVQ) ideas (Laroia and Farvardin, 1993) with trellis coded quantization (Marcellin and Fischer, 1990). The resulting quantizer is called the trellis-based scalar-vector quantizer (TB-SVQ). The SVQ structure allows the TB-SVQ to realize a large boundary gain while the underlying trellis code enables it to achieve a significant portion of the total granular gain. For large block-lengths and powerful (possibly complex) trellis codes the TB-SVQ can, in principle, achieve the rate-distortion bound. As indicated by the results obtained, even for reasonable block-lengths and relatively simple trellis codes, the TB-SVQ outperforms all other fixed-rate quantizers at reasonable complexity. >
Enantiopure Indolizinoindolones with in vitro Activity against Blood‐ and Liver‐Stage Malaria Parasites (2015)

Malaria continues to be a major cause of morbidity and mortality to this day, and resistance to drugs like chloroquine has led to an urgent need to discover novel chemical entities aimed at new targets. Here, we report the discovery of a novel class of potential antimalarial compounds containing an indolizinoindolone scaffold. These novel enantiopure indolizinoindolones were synthesized, in good-to-excellent yields and excellent diastereoselectivities, by cyclocondensation reaction of (S)- or (R)-tryptophanol and 2-acyl benzoic acids, followed by intramolecular α-amidoalkylation. Interestingly, we were able to synthesize for the first time 7,13b-cis indolizinoindolones in a two-step route. The novel compounds showed promising activity against erythrocytic stages of the human malaria parasite, Plasmodium falciparum, and liver stages of the rodent parasite Plasmodium berghei. In particular, an (S)-tryptophanol-derived isoindolinone was identified as a promising starting scaffold to search for novel antimalarials, combining excellent activity against both stages of the parasite's life cycle with low cytotoxicity and excellent metabolic and chemical stability in vitro.
Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues (1994)

We have reported that membranous protein kinase C (PKC) activities and total diacylglycerol (DAG) levels are increased in the heart and aorta of diabetic rats, which cannot be easily reversed by euglycemic control. However, insulin treatment, which achieved euglycemia, can prevent the increase in PKC activities and DAG levels. Chronic exposure to elevated glucose levels (5.5 vs. 22 mM) increased DAG levels in cultured bovine and rat aortic endothelial cells and smooth muscle cells by 31, 140, and 143%, respectively, only after 3 days of incubation. Glyceraldehyde, which can stimulate the de novo synthesis of DAG, significantly increased DAG levels by 7.1 +/- 0.6-fold after only 16 h of incubation. Elevated glucose levels did not affect labeled DAG when all of the vascular cells were incubated with [3H]arachidonate, [3H]glycerol, or [3H]phosphatidylcholine, whereas [3H]palmitate- and [3H]oleic acid-labeled DAG levels were significantly increased, indicating that the glucose-stimulated increase in DAG is derived partially from the de novo synthesis pathway. Immunoblotting studies showed increases only in PKC isoform beta II but not alpha in aortic smooth muscle cells. The phosphorylation level of MARCKS protein, an intracellular substrate of PKC, was also increased, consistent with the PKC activity increase. These findings showed that diabetic and hyperglycemia-induced increases in PKC activity and DAG levels in the heart and aorta are preventable by insulin treatment.
Nanoparticules mésoporeuses de silice (MSN) et applications biologiques (2009)

Des nanoparticules mésoporeuses de silice (MSN), c'est-à-dire des particules d'un diamètre de l'ordre de 60 à 300 nm, possédant une porosité organisée en réseau hexagonal avec des diamètres de pores de 1,5 à 10 nm et de grandes surfaces spécifiques de l'ordre de 1000 m2.g-1, ont pu être synthétisées. Elles possèdent des propriétés uniques, notamment une grande surface spécifique et une distribution étroite de taille de pores. Elles peuvent être facilement fonctionnalisées et sont biocompatibles, ce qui en font des candidates idéales pour des applications biologiques. Ainsi, des MSN ont été utilisées pour le marquage cellulaire, en encapsulant dans leurs pores des fluorophores mono ou biphotoniques. Elles trouvent également des utilisations en transfection génétique ou comme agents de contraste en IRM. Enfin, les systèmes de délivrance contrôlée de médicaments en sont une des applications les plus prometteuses pour l'amélioration de la santé humaine.
GHz-range resonant ultrasound spectroscopy for a free-standing nano film studied by picosecond ultrasonics (2019)

GHz-range resonant ultrasound spectroscopy