gebhart/patrepeval huggingface dataset:
Modeling of U-shaped and plugged emitter resistance of high speed SiGe HBTs (2011)

In this paper, we investigate the emitter resistance R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">e</inf> in SiGe HBTs with speeds up to 280GHz, using a U-shaped polysilicon emitter. We observed that R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">e</inf> increased with lateral scaling, thereby degrading f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> . Although a negligible component in the past, in this experiment R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">e</inf> * C <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">cb</inf> transit time delay is playing a more significant role in limiting f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> . R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">e</inf> was modeled to explain the increase due to lateral scaling, and was shown to result from the plugging of the emitter opening by the emitter polysilicon. Furthermore, process experiments were conducted to investigate the effect of emitter polysilicon thickness, sidewall height, and emitter i-layer thickness.
The bright side of dark matter: lncRNAs in cancer (2016)

The traditional view of genome organization has been upended in the last decade with the discovery of vast amounts of non-protein-coding transcription. After initial concerns that this "dark matter" of the genome was transcriptional noise, it is apparent that a subset of these noncoding RNAs are functional. Long noncoding RNA (lncRNA) genes resemble protein-coding genes in several key aspects, and they have myriad molecular functions across many cellular pathways and processes, including oncogenic signaling. The number of lncRNA genes has recently been greatly expanded by our group to triple the number of protein-coding genes; therefore, lncRNAs are likely to play a role in many biological processes. Based on their large number and expression specificity in a variety of cancers, lncRNAs are likely to serve as the basis for many clinical applications in oncology.
Extracorporeal carbon dioxide removal in heart-beating donor with acute severe asthma: A case report (2020)

Status asthmaticus is a life-threatening disorder that can manifest in dangerous levels of hypercapnia and acidosis. The use of extracorporeal carbon dioxide removal (ECCO2R) has been used successfully to control pH and PaCO<sub>2</sub> in patients with acute severe asthma. The present report describes the use of this technology in near-fatal asthma with brain death, and awaiting organ harvest. The ProLUNG® system consists of a veno-venous hemoperfusion circuit with an artificial lung polymethylpentene membrane coated with phosphorylcholine with a surface of 1.81 m<sup>2</sup>. The system can reach a blood flow of 450 ml/min trough a double-lumen central venous catheter (13.0 Fr) placed in femoral, subclavian or jugular vein. The platform is provided with automated management of airflow and VCO<sub>2</sub> monitoring during treatment. The patient was maintained on extracorporeal treatment ensuring stable arterial pH control and PaCO<sub>2</sub> control. In acute status asthmaticus, complicated with cardiac arrest, mini-invasive ECCO2R was an effective method of controlling pH and PaCO<sub>2</sub>, for optimizing hemodynamic and aerobic metabolism and for performing protective ventilation for an optimal organ donor preservation until the organ harvest occurs.
Impact of platelet transfusion on toxicity and mortality after hematopoietic progenitor cell transplantation (2014)

HPCT-related toxicity and mortality are associated with increased PLT transfusion events. Alternative strategies to reduce PLT transfusions after HPCT may warrant future study.
SPOC1: a novel PHD-containing protein modulating chromatin structure and mitotic chromosome condensation (2009)

In this study, we characterize the molecular and functional features of a novel protein called SPOC1. SPOC1 RNA expression was previously reported to be highest in highly proliferating tissues and increased in a subset of ovarian carcinoma patients, which statistically correlated with poor prognosis and residual disease. These observations implied that SPOC1 might play a role in cellular proliferation and oncogenesis. Here we show that the endogenous SPOC1 protein is labile, primarily chromatin associated and its expression as well as localization are regulated throughout the cell cycle. SPOC1 is dynamically regulated during mitosis with increased expression levels and biphasic localization to mitotic chromosomes indicating a functional role of SPOC1 in mitotic processes. Consistent with this postulate, SPOC1 siRNA knockdown experiments resulted in defects in mitotic chromosome condensation, alignment and aberrant sister chromatid segregation. Finally, we have been able to show, using micrococcal nuclease (MNase) chromatin-digestion assays that SPOC1 expression levels proportionally influence the degree of chromatin compaction. Collectively, our findings show that SPOC1 modulates chromatin structure and that tight regulation of its expression levels and subcellular localization during mitosis are crucial for proper chromosome condensation and cell division.
Development and Performance Testing of the Hex Mud Pump (2003)

Abstract This paper focuses on the development process of the Hex pump. Computer assisted analysis has been used extensively to optimize the pump structure and vital parts with respect to weight, strength and life. Interactive computer programs for replacing paper based documentation and service manuals have also been developed.
The MIT 'Monarch' and the Kremer World Speed Competition (1985)

The race for the Kremer World Speed Record was the closest human powered aircraft competition yet. Throughout the summer of 1983, teams in Massachusetts and California worked to construct aircraft capable of completing the 1500 meter Kremer Course in less than three minutes. Between August 14 and Septernber 23, the MIT Monarch successfully demonstrated all of the components of the Kremer Course and began making record attempts. 0n September 23, the Monarch was damaged in a landing accident, and subsequently disassembled due to pressures of the academic term. This paper traces the design and development of the Monarch.
Innovative Technology and Advanced Engineering Prove Concept for Future Field Development of an Ultra-HPHT Unconventional Gas Reservoir (2017)

Abstract The well X in the reservoir Y of the Z basin comprises several low permeability siltstone reservoirs which require propped fracture stimulation to produce at economically attractive rates. This region is known for an abnormally high geothermal gradient, resulting in bottom-hole static temperatures over 210degC / 410degF. This paper will describe the state-of-the-art technologies and techniques required to successfully complete the well and optimize well and completion design for future field development. Due to the extreme conditions, new technologies and techniques were required to address key challenges and ensure the success of the project. A novel, state-of-the-art fracturing fluid was successfully applied to ensure fluid stability when faced with temperatures in excess of 210 degC. Tracers and high temperature diagnostic tools were deployed to aid with onsite design changes and later to evaluate fracture geometry and production performance. The onsite execution data was combined with post-job diagnostics and well test data to evaluate well, formation and fracture performance with aim of optimizing well and completion design for new wells in the field. Three fracturing stages were successfully completed in this ultra-high temperature tight gas well. The key technologies and techniques applied enabled the successful completion of the operation and, more importantly, provided the data crucial for optimizing well and completion design for future wells. The well achieved commercial production rates and provided proof-of-concept for future field development. Advanced production enhancement design workflows have played a key role in optimizing job design, assessing job performance and evaluating the completion strategies required for future field development. A new ultra-high temperature fracturing fluid was applied for the first time in Europe. The first application of ultra-high temperature bottomhole gauges for reservoir characterization was performed. A reservoir centric fracture simulator was used to design and evaluate fracture performance, production prediction and optimize future well and completion designs.
The Oxidation Reaction of Lead Sulfate Formed at the Interface Between the Lead Plate and the Porous Active Material of a Lead Acid Battery (1990)

Porous lead dioxide prepared on the lead substrate was discharged galvanostatically and then discharged at −450 mV from the equilibrium potential of potentiostatically. The state of the interface between porous lead dioxide and the lead substrate scarcely changed after the galvanostatic discharge. On the other hand, after the following potentio‐static discharge, the large, plate‐like lead sulfate crystals were formed at the interface between porous lead dioxide and the lead substrate. Then, such an electrode was oxidized potentiostatically. The oxidation current‐time transients implied the existence of the electronic resistance in the electrode. Such a resistance was related to the large, plate‐like lead sulfate crystals which were formed at the interface between porous lead dioxide and the lead substrate during the potentiostatic discharge. These lead sulfate crystals were not oxidizable and remained at the interface between porous lead dioxide and the lead substrate.
Antisense therapies for movement disorders (2019)

Currently, few disease-modifying therapies exist for degenerative movement disorders. Antisense oligonucleotides are small DNA oligonucleotides, usually encompassing ∼20 base pairs, that can potentially target any messenger RNA of interest. Antisense oligonucleotides often contain modifications to the phosphate backbone, the sugar moiety, and the nucleotide base. The development of antisense oligonucleotide therapies spinal muscular atrophy and Duchenne muscular dystrophy suggest potentially wide-ranging therapeutic applications for antisense oligonucleotides in neurology. Successes with these two diseases have heightened interest in academia and the pharmaceutical industry to develop antisense oligonucleotides for several movement disorders, including, spinocerebellar ataxias, Huntington's disease, and Parkinson's disease. Compared to small molecules, antisense oligonucleotide-based therapies have an advantage because the target disease gene sequence is the immediate path to identifying the therapeutically effective complementary antisense oligonucleotide. In this review we describe the different types of antisense oligonucleotide chemistries and their potential use for the treatment of human movement disorders. © 2019 International Parkinson and Movement Disorder Society.
Brain calcifications and PCDH12 variants (2017)

Brain calcifications should be added to the phenotypic spectrum associated with <i>PCDH12</i> biallelic loss of function, in the context of severe cerebral developmental abnormalities. A putative role for <i>PCDH12</i> variants remains to be determined in PFBC.
On the analytical modeling of database concurrency control (1993)

The Concurrency Control (CC) scheme employed can profoundly affect the performance of transaction-processing systems. In this paper, a simple unified approximate analysis methodology to model the effect on system performance of data contention under different CC schemes and for different system structures is developed. This paper concentrates on modeling data contention and then, as others have done in other papers, the solutions of the data contention model are coupled with a standard hardware resource contention model through an iteration. The methodology goes beyond previously published methods for analyzing CC schemes in terms of the generality of CC schemes and system structures that are handled. The methodology is applied to analyze the performance of centralized transaction processing systems using various optimistic- and pessimistic-type CC schemes and for both fixed-length and variable-length transactions. The accuracy of the analysis is demonstrated by comparison with simulations. It is also shown how the methodology can be applied to analyze the performance of distributed transaction-processing systems with replicated data.
ChemInform Abstract: SYNTHETIC STUDIES TOWARD MITOMYCINS. III. TOTAL SYNTHESES OF MITOMYCINS A AND D C (1978)

Abstract Die Synthese von Mitomycin A (IVa) schließt an bekannte Synthesen in der Mitomycin‐Reihe an.
Grb10 Interacts Differentially with the Insulin Receptor, Insulin-like Growth Factor I Receptor, and Epidermal Growth Factor Receptor via the Grb10 Src Homology 2 (SH2) Domain and a Second Novel Domain Located between the Pleckstrin Homology and SH2 Domains (1998)

The Grb10 protein appears to be an adapter protein of unknown function that has been implicated in insulin receptor (IR) signaling. The interaction of this protein with the IR has been shown to be mediated in part by the Src homology 2 (SH2) domain of Grb10. Here we demonstrate the existence of a second novel domain within Grb10 that interacts with the IR and insulin-like growth factor receptor in a kinase-dependent manner. This domain was localized to a region of approximately 50 amino acids, and we term it the BPS domain to denote its location between the PH and SH2 domains. The BPS domain does not bear any obvious resemblance to other known protein interaction domains but is highly conserved among the Grb10-related proteins Grb7 and Grb14. We show that the BPS domain interaction is dependent upon receptor tyrosine kinase activity. Furthermore, interaction of the BPS domain requires the kinase domain of the IR, since mutation of the paired tyrosine residues (Y1150F/Y1151F) within the IR activation loop dramatically reduced the interaction. Last, our data suggest that the presence of two distinct protein interaction domains may help to determine the specificity by which Grb10 interacts with different receptors. Specifically, the IR, which appears to interact most strongly with Grb10, interacts well with both the SH2 and BPS domains. Conversely, the insulin-like growth factor receptor and EGFR, which interact less avidly with Grb10, interact well only with the BPS domain or the SH2 domain, respectively. In summary, our findings demonstrate the existence of a previously unidentified tyrosine kinase activity-dependent binding domain located between the Pleckstrin homology and SH2 domains of Grb10.
Quantification of the Material Ductility Effect on Notch Fracture Toughness Using Numerical Damage Analysis Method (2020)

Abstract In this study, the finite element (FE) damage analysis based on the multi-axial fracture strain model was applied to investigate the effect of the material ductility on fracture resistance of notched defect. (The fracture toughness is used only for a cracked specimen and the fracture resistance is used for notched specimens throughout the paper.) To obtain the material property with different ductility, the tensile and fracture toughness tests of the cold-worked SUS316 were used. The damage model was determined from comparing the experimental data with simulated FE analysis results. Then the FE analysis was applied to calculate the fracture resistance according to the notch radius in each material. It shows that the slope of initiation resistance according to the notch radius was related to the material ductility. To quantify this effect of ductility, the relationship between notch fracture resistance and material tensile properties was confirmed.
Curation of BIDS (CuBIDS): A workflow and software package for streamlining reproducible curation of large BIDS datasets (2022)

The Brain Imaging Data Structure (BIDS) is a specification accompanied by a software ecosystem that was designed to create reproducible and automated workflows for processing neuroimaging data. BIDS Apps flexibly build workflows based on the metadata detected in a dataset. However, even BIDS valid metadata can include incorrect values or omissions that result in inconsistent processing across sessions. Additionally, in large-scale, heterogeneous neuroimaging datasets, hidden variability in metadata is difficult to detect and classify. To address these challenges, we created a Python-based software package titled "Curation of BIDS" (CuBIDS), which provides an intuitive workflow that helps users validate and manage the curation of their neuroimaging datasets. CuBIDS includes a robust implementation of BIDS validation that scales to large samples and incorporates DataLad--a version control software package for data--as an optional dependency to ensure reproducibility and provenance tracking throughout the entire curation process. CuBIDS provides tools to help users perform quality control on their images' metadata and identify unique combinations of imaging parameters. Users can then execute BIDS Apps on a subset of participants that represent the full range of acquisition parameters that are present, accelerating pipeline testing on large datasets.
Collagen Synthesis in Growing Human Skin Fibroblasts (1986)

Collagen and noncollagen protein synthesis in cultured human skin fibroblasts was studied in relation to different growth phases. In order to quantify collagen synthesis, we determined the release of incorporated radioactivity using purified bacterial collagenase. Collagen as well as noncollagen protein synthesis markedly decreased during fibroblast growth. On the other hand, we found a 3-fold increase in relative collagen synthesis (i.e. collagen synthesis compared to total protein synthesis) comparing cells in the log growth phase with cells in the stationary growth phase.
Achieving maximum power efficiency of a novel rectifier charge pump by impedance matching in an energy harvester suited for self-powered sensors (2013)

A new rectifier (AC-DC) charge pump with impedance matching is proposed in this study for maximizing power transfer efficiency in an energy harvester circuitry equipping self-powered sensors. In addition to the rectifier charge pump, there are power management circuits, a low dropout regulator and a battery charger to complete the energy harvester circuitry module for self-power sensors. The proposed circuit is suitable for harvesting the low-frequency vibration energy in portable medical sensors or low-power high-frequency RFID sensors. In the harvester circuit, the rectifier charge pump operated in dual phase is proposed to preform efficient conversion of vibratory AC powers to DC by means of automatic switchings and capacitors. To optimize the charge pump circuit, a charging equivalent model is first derived, where all capacitances are optimized to derive maximum average energy stored in capacitors and then transferred to loadings. The design rules are distilled based on rigorous analysis, and the capacitances are optimized based on the relation between the energy stored in capacitances and inherent electronic properties of the harvester. The chips with optimized capacitances are fabricated by the TSMC 0.35um process for verification. It is shown theoretically and experimentally that implementation of the proposed optimized circuit is able to harvest more power than un-optimized.
Pu(V) reduction and enhancement of particle-water partitioning by exopolymeric substances (2008)

Abstract Central to understanding the environmental behavior of Pu in vadose- and saturated-zones, as well as waste streams, is the contribution of colloidal natural organic mater (NOM), e.g. , biopolymeric exopolymeric substances (EPS) from Pseudomonas fluorescens Biovar II and geopolymeric humic acids (HA), to Pu speciation. Because Pu(V) and Pu(IV) are present in aquatic systems at sub-pM concentrations, many established techniques for chemical speciation and oxidation state determination are not available. However, the two redox states of Pu can be distinguished through their tendency to form colloidal species. Controlled laboratory experiments with low-colloid background solutions of 0.1 M NaClO 4 with an inert buffer (Tris) and 5 μm silica particles of high specific surface area (500 m 2 /g) and small (3 nm) pores investigated the ability of NOM compounds for their binding and redox qualities showed that: 1) Pu(V) and Pu(IV) tracers at pM concentrations could be distinguished by their tendency to bind to colloidal species (≥1 kDa), with binding extent being high for Pu(IV), and low for Pu(V); 2) EPS can significantly enhance particle- (or colloid-) water partition coefficients to silica particles ( K d , K dc ), quickly (1 day) for Pu(IV) and slowly (1 month) for Pu(V); 3) Pu(V), in the presence of EPS and silica particles can become associated with particles and colloids over periods of months, likely indicating reduction; 4) K d values can be affected by the reaction sequence of tracer addition to the solution containing silica particles and NOM compounds ( e.g. , EPS or HA).
Antenna coupled Kinetic Inductance Detectors for space based sub-mm astronomy (2008)

To achieve background limited detection, future space missions in the far infrared and sub-mm radiation bands will require large arrays (&gt;1000 pixels) of very sensitive detectors. A typical requirement for the noise equivalent power is 10^-19 W/Hz^0.5 for a Fourier Transform Spectrometer, which is 100 to 1000 times more sensitive than the state of the art such as on HERSCHEL. Such low NEP is a significant technical challenge, both to achieve for the detectors and to demonstrate in the laboratory. Kinetic inductance detectors can theoretically achieve this performance and have significant advantages over other types of detectors, for example are well adapted to frequency domain multiplexing. We present antenna coupled kinetic inductance detectors, showing the loaded optical NEP measured with a well controlled narrow band black body radiation source. We will also discuss the optimization route required to reach the requirements for future missions, including the optical testing requirements
Room-temperature oxygen sensitization in highly textured, nanocrystalline PbTe films: A mechanistic study (2011)

In this paper, we report large mid-wave infrared photoconductivity in highly textured, nanocrystalline PbTe films thermally evaporated on Si at room temperature. Responsivity as high as 25 V/W is measured at the 3.5 μm wavelength. The large photoconductivity is attributed to the oxygen incorporation in the films by diffusion. Carrier concentration as low as 1017 cm−3 is identified to be the consequence of Fermi level pinning induced by the diffused oxygen. The successful demonstration of IR-sensitive PbTe films without the need for high-temperature processing presents an important step toward monolithic integration of mid-wave PbTe infrared detectors on Si read-out integrated circuits (ROICs).
Convex/Schur-Convex (CSC) Log-Priors (1999)

The folk theorem that sparsity inducing priors should be supergaussian can be rigorously stated in the low-noise limit, assuming the validity of a particular stochastic generative model. For the assumed model it is shown that supergaussianess is necessary, but not sufficient, for sparse signal coding when a Maximum A Posterior (MAP) coding is found.
Binding affinity (K<sub>D</sub>) of ligands to MCL1 and MBP-MCL1. (2015)

&lt;p&gt;All experiments are n ≥ 3, and averaged values for K&lt;sub&gt;D&lt;/sub&gt; are reported.&lt;/p&gt;&lt;p&gt;Binding affinity (K&lt;sub&gt;D&lt;/sub&gt;) of ligands to MCL1 and MBP-MCL1.&lt;/p&gt;