gebhart/patrepeval huggingface dataset:
3D Reconstruction of the Human Airway Mucosa In Vitro as an Experimental Model to Study NTHi Infections (2016)

We have established an in vitro 3D system which recapitulates the human tracheo-bronchial mucosa comprehensive of the pseudostratified epithelium and the underlying stromal tissue. In particular, we reported that the mature model, entirely constituted of primary cells of human origin, develops key markers proper of the native tissue such as the mucociliary differentiation of the epithelial sheet and the formation of the basement membrane. The infection of the pseudo-tissue with a strain of NonTypeable Haemophilus influenzae results in bacteria association and crossing of the mucus layer leading to an apparent targeting of the stromal space where they release large amounts of vesicles and form macro-structures. In summary, we propose our in vitro model as a reliable and potentially customizable system to study mid/long term host-pathogen processes.
ChemInform Abstract: Chiral Diaminodiamide Copper(II) Complexes for the Enantioselective Recognition of Amino Acids: Synthesis of the Ligands and Formation Constants. (1987)

Abstract The bis(aminoacyl)alkanediamines (III) are prepared from the compounds (I) and (II).
N-Benzoyl-16-acetylcycloxobuxidine: A New Alkaloid from the Leaves ofBuxus papilosa (1987)

A new alkaloid, N-benzoyl-16-acetylcycloxobuxidine, has been isolated from the leaves of BUXUS PAPILOSA, to which structure 1 has been assigned.
Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review (2007)

Based on this critical review of the published literature, direct hemoperfusion with PMX-F appears to have favorable effects on MAP, dopamine use, PaO2/FiO2 ratio, and mortality. However, publication bias and lack of blinding need to be considered. These findings support the need for further rigorous study of this therapy.
Equalizer Complexity of Mode Division Multiplexed Coherent Receivers (2012)

We show that OFDM requires the lowest equalizer complexity for crosstalk compensation in a mode-division-multiplexing receiver. For a 2000-km transmission distance and less than 10% OFDM-specific overhead, the modal dispersion must be below 12 ps/km.
Efficient estimation from right-censored data when failure indicators are missing at random (1998)

The Kaplan-Meier estimator of a survival function is well known to be asymptotically efficient when cause of failure is always observed. It has been an open problem, however, to find an efficient estimator when failure indicators are missing at random. Lo showed that nonparametric maximum likelihood estimators are inconsistent, and this has led to several proposals of ad hoc estimators, none of which are efficient. We now introduce a sieved nonparametric maximum likelihood estimator, and show that it is efficient. Our approach is related to the estimation of a bivariate survival function from bivariate right-censored data.
ChemInform Abstract: Episulfonium Ions May Not be the Stereo‐Determinants in Glycosidations of 2‐Thioalkyl Pyranosides (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Synthesis and characterization of model urethane compounds (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of model urethane compoundsZ. Y. Qin, C. W. Macosko, and Stephen T. WellinghoffCite this: Macromolecules 1985, 18, 3, 553–557Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/ma00145a040https://doi.org/10.1021/ma00145a040research-articleACS PublicationsRequest reuse permissionsArticle Views228Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Genomas, Inc. (2004)

Genomas, Inc. is developing novel diagnostic products to personalize disease prevention and health enhancement. The company's proprietary PhysioGenomics™ technology allows it to rapidly and precisely produce 'PhysioTypes™'. PhysioTypes are predictors of response to diet, exercise, and drugs (not diagnostics for disease), and are utilized to direct preventive strategies. A PhysioType is made from the combination of all genetic, physiological or clinical markers that Genomas has discovered to be significant determinants of individual response. PhysioTypes are revolutionary healthcare products that empower physicians with the unprecedented capability to prescribe personalized and highly effective preventive treatments, incorporating diet, exercise and drug regimens for each patient. Genomas conducts clinical research with major clinical institutions to discover these PhysioTypes with plans to commercialize them to practicing physicians and hospitals.
Performing a local reduction operation on a parallel computer (2023)

A parallel computer including compute nodes, each including two reduction processing cores, a network write processing core, and a network read processing core, each processing core assigned an input buffer. Copying, in interleaved chunks by the reduction processing cores, contents of the reduction processing cores&#x27; input buffers to an interleaved buffer in shared memory; copying, by one of the reduction processing cores, contents of the network write processing core&#x27;s input buffer to shared memory; copying, by another of the reduction processing cores, contents of the network read processing core&#x27;s input buffer to shared memory; and locally reducing in parallel by the reduction processing cores: the contents of the reduction processing core&#x27;s input buffer; every other interleaved chunk of the interleaved buffer; the copied contents of the network write processing core&#x27;s input buffer; and the copied contents of the network read processing core&#x27;s input buffer.
Carbon-Nanotube-Embedded Hydrogel Sheets for Engineering Cardiac Constructs and Bioactuators (2013)

We engineered functional cardiac patches by seeding neonatal rat cardiomyocytes onto carbon nanotube (CNT)-incorporated photo-cross-linkable gelatin methacrylate (GelMA) hydrogels. The resulting cardiac constructs showed excellent mechanical integrity and advanced electrophysiological functions. Specifically, myocardial tissues cultured on 50 μm thick CNT-GelMA showed 3 times higher spontaneous synchronous beating rates and 85% lower excitation threshold, compared to those cultured on pristine GelMA hydrogels. Our results indicate that the electrically conductive and nanofibrous networks formed by CNTs within a porous gelatin framework are the key characteristics of CNT-GelMA leading to improved cardiac cell adhesion, organization, and cell-cell coupling. Centimeter-scale patches were released from glass substrates to form 3D biohybrid actuators, which showed controllable linear cyclic contraction/extension, pumping, and swimming actuations. In addition, we demonstrate for the first time that cardiac tissues cultured on CNT-GelMA resist damage by a model cardiac inhibitor as well as a cytotoxic compound. Therefore, incorporation of CNTs into gelatin, and potentially other biomaterials, could be useful in creating multifunctional cardiac scaffolds for both therapeutic purposes and in vitro studies. These hybrid materials could also be used for neuron and other muscle cells to create tissue constructs with improved organization, electroactivity, and mechanical integrity.
Fabrication of Low-Invasive Patch Glucose Sensors (2015)

A low invasive glucose sensor, which has sensing region at the tip of a fine tapered electrode, was developed for continuous glucose monitoring. Platinum-Iridium alloy electrode was settled at the middle of tapered PEEK tube and was employed as sensing electrode. Electrodeposition of glucose oxidase in the presence of surfactant, Triton X-100, was performed for high-density enzyme immobilization, and was followed by the electropolymerization of o-phenylenediamine for the formation of functional entrapping and permselective polymer membrane. Amperometric responses of the prepared sensors to glucose were measured at a potential of 0.60 V (vs. Ag/AgCl). The sensor showed the sensitivity of 5.387 mA/cm 2 mM, r 2 =0.992, and a good linear range from up to 21.6 mM glucose.
Porous Films from TiO[sub 2] (Anatase) with Bimodal Morphology (2007)

Mechanically stable (anatase) thin films were fabricated from a mixture of two kinds of particles: nano (ca. ) and submicrometer (ca. )-sized ones. These bimodal films were further modified by deposition of ultrasmall particles via treatment. Electrochemical insertion of lithium turned out to be a suitable method for characterization of the films' morphology. Different particle sizes can be detected by cyclic voltammetry, because the potential of the anodic (Li extraction) peak shifts regularly with the particle size.
An investigation on defect-generation conditions in immersion lithography (2006)

As a powerful candidate for a lithography technique that can accommodate the scaling-down of semiconductors, 193-nm immersion lithography-which realizes a high numerical aperture (NA) and uses deionized water as the medium between the lens and wafer in the exposure system-has been developing at a rapid pace and has reached the stage of practical application. In regards to defects that are a cause for concern in the case of 193-nm immersion lithography, however, many components are still unclear and many problems remain to be solved. It has been pointed out, for example, that in the case of 193-nm immersion lithography, immersion of the resist film in deionized water during exposure causes infiltration of moisture into the resist film, internal components of the resist dissolve into the deionized water, and residual water generated during exposure affects post-processing. Moreover, to prevent this influence of directly immersing the resist in de-ionized water, application of a protective film is regarded as effective. However, even if such a film is applied, it is still highly likely that the above-mentioned defects will still occur. Accordingly, to reduce these defects, it is essential to identify the typical defects occurring in 193-nm immersion lithography and to understand the condition for generation of defects by using some kinds of protective films and resist materials. Furthermore, from now onwards, with further scaling down of semiconductors, it is important to maintain a clear understanding of the relation between defect-generation conditions and critical dimensions (CD). Aiming to extract typical defects occurring in 193-nm immersion lithography, the authors carried out a comparative study with dry exposure lithography, thereby confirming several typical defects associated with immersion lithography. We then investigated the conditions for generation of defects in the case of some kinds of protective films. In addition to that, by investigating the defect-generation conditions and comparing the classification data between wet and dry exposure, we were able to determine the origin of each particular defect involved in immersion lithography. Furthermore, the comparison of CD for wet and dry processing could indicate the future defectivity levels to be expected with shrinking immersion process critical dimensions.
Performance of Bandwidth Extension Techniques for High-Speed Short-Range IM/DD Links (2019)

In recent years, advanced modulation formats for short-range high-speed communications have been increasingly discussed to achieve the transmission rates needed to satisfy the future demand of broadband services. A key parameter in such applications is the use of low-cost optical components, which mainly means the use of intensity modulation (IM) and direct detection (DD) schemes. In order to exploit the available bandwidth offered by the latest optical components, high-speed data converters (DAC and ADC) are required. However, the available bandwidth of DACs and ADCs is generally smaller, than that of their optical counterparts, resulting in a capacity bottleneck. This issue can be addressed by bandwidth extension techniques, which enable the full use of the optical components. In this paper, two high-speed systems are presented and experimentally analyzed for an optical link based on IM/DD, utilizing a bandwidth extension technique based on electrical up/down-conversion and passive signal combining. The experiment for the first system uses two independent subsignals, with a total bandwidth beyond 40 GHz and enables transmission rates up to 180 Gb/s. Different aspects of the system are highlighted including general performance, transmission distance, use of different modulation formats, and the influence of important components. For the second system, the experiment consists of the generation of a spectrally continuous pulse amplitude modulation signal with the help of two subsignals and its transmission over an optical IM/DD link. The challenges and requirements for the hardware and software are discussed and the impact of power and phase mismatches between both subsignals is investigated as well.
Principles of Frontal Lobe Function (2002)

Abstract This book provides a review of historical and current research on the function of the frontal lobes and frontal systems of the brain. The content spans frontal lobe functions from birth to old age, from biochemistry and anatomy to rehabilitation, and from normal to disrupted function. The book covers a variety of disciplines including neurology, neuroscience, psychiatry, psychology, and health care.
Threshold-Voltage Shifts in Organic Transistors Due to Self-Assembled Monolayers at the Dielectric: Evidence for Electronic Coupling and Dipolar Effects (2015)

The mechanisms behind the threshold-voltage shift in organic transistors due to functionalizing of the gate dielectric with self-assembled monolayers (SAMs) are still under debate. We address the mechanisms by which SAMs determine the threshold voltage, by analyzing whether the threshold voltage depends on the gate-dielectric capacitance. We have investigated transistors based on five oxide thicknesses and two SAMs with rather diverse chemical properties, using the benchmark organic semiconductor dinaphtho[2,3-b:2',3'-f]thieno[3,2-b]thiophene. Unlike several previous studies, we have found that the dependence of the threshold voltage on the gate-dielectric capacitance is completely different for the two SAMs. In transistors with an alkyl SAM, the threshold voltage does not depend on the gate-dielectric capacitance and is determined mainly by the dipolar character of the SAM, whereas in transistors with a fluoroalkyl SAM the threshold voltages exhibit a linear dependence on the inverse of the gate-dielectric capacitance. Kelvin probe force microscopy measurements indicate this behavior is attributed to an electronic coupling between the fluoroalkyl SAM and the organic semiconductor.
10.1162/153244301753683717 (2000)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
N-Heterocyclic Carbene–Copper-Catalyzed Group-, Site-, and Enantioselective Allylic Substitution with a Readily Accessible Propargyl(pinacolato)boron Reagent: Utility in Stereoselective Synthesis and Mechanistic Attributes (2015)

The first instances of catalytic allylic substitution reactions involving a propargylic nucleophilic component are presented; reactions are facilitated by 5.0 mol % of a catalyst derived from a chiral N-heterocyclic carbene (NHC) and a copper chloride salt. A silyl-containing propargylic organoboron compound, easily prepared in multigram quantities, serves as the reagent. Aryl- and heteroaryl-substituted disubstituted alkenes within allylic phosphates and those with an alkyl or a silyl group can be used. Functional groups typically sensitive to hard nucleophilic reagents are tolerated, particularly in the additions to disubstituted alkenes. Reactions may be performed on the corresponding trisubstituted alkenes, affording quaternary carbon stereogenic centers. Incorporation of the propargylic group is generally favored (vs allenyl addition; 89:11 to >98:2 selectivity); 1,5-enynes can be isolated in 75-90% yield, 87:13 to >98:2 SN2'/SN2 (branched/linear) selectivity and 83:17-99:1 enantiomeric ratio. Utility is showcased by conversion of the alkynyl group to other useful functional units (e.g., homoallenyl and Z-homoalkenyl iodide), direct access to which by other enantioselective protocols would otherwise entail longer routes. Application to stereoselective synthesis of the acyclic portion of antifungal agent plakinic acid A, containing two remotely positioned stereogenic centers, by sequential use of two different NHC-Cu-catalyzed enantioselective allylic substitution (EAS) reactions further highlights utility. Mechanistic investigations (density functional theory calculations and deuterium labeling) point to a bridging function for an alkali metal cation connecting the sulfonate anion and a substrate's phosphate group to form the branched propargyl addition products as the dominant isomers via Cu(III) π-allyl intermediate complexes.
Both C3a and C3adesArg Regulate Interleukin‐6 Synthesis in Human Peripheral Blood Mononuclear Cells (1998)

Synthesis of complement components is part of the acute-phase response. Interleukin-6 (IL-6) is a critical mediator of the acute-phase response during infections and injuries. Plasma levels of C3a and IL-6 have been proposed as prognostic indicators in sepsis and trauma. The effects of C3a and C3a(des)Arg on IL-6 gene expression and protein production in human peripheral blood mononuclear cells (PBMC) were investigated. Neither C3a nor C3a(des)Arg alone induced detectable IL-6 protein or mRNA levels. However, C3a and C3a(des)Arg affected endotoxin-induced IL-6 synthesis in a dose-dependent manner. In nonadherent PBMC, C3a or C3a(des)Arg suppressed, while in adherent PBMC, C3a or C3a(des)Arg enhanced IL-6 protein and mRNA levels. These results suggest that C3a and C3a(des)Arg may provide a control mechanism of acute-phase responses by enhancing IL-6 synthesis in adherent monocytes at local inflammatory sites and by inhibiting IL-6 synthesis in circulating monocytes.
<title>Soft computing and soft communication (SC2) hybrid rf wireless communication platforms and interfaces for BLOS and sensor WLAN applications</title> (2001)

A new type of Wireless Local Area Network (WLAN) is proposed for visual sensor communication, for both local and BLOS (Beyond-Line-of-Sight) wireless communication.
Automated Triplexed Hepatocyte-Based Viability and CYP1A and -3A Induction Assays (2011)

Cytochrome P450 (CYP) enzymes are key players in drug metabolism. Therefore, it is essential to understand how these enzymes can be affected by xenobiotics with regards to induction and toxicity to avoid potential drug–drug interactions. Typically, information has been gathered by combining data from multiple experiments, which is time-consuming and labor intensive, and interassay variability may lead to misinterpretation. Monitoring CYP induction and cytotoxicity by xenobiotics using an automated, multiplexed format can decrease workload and increase data confidence. Here the authors demonstrate the ability to monitor CYP1A and CYP3A4 induction, combined with a cytotoxicity measurement, from a single microplate well using cryopreserved human hepatocytes. The assay procedure was automated in a 384-well format, including cell manipulations, compound titration and transfer, and reagent dispensing, using simple robotic instrumentation. EC50 and Emax values were derived for multiple known CYP1A and -3A4 inducers. Induction and toxicological responses in the triplex system were validated based on literature values from conventional single-parameter assays. Validation and pharmacology data confirm that multiplexed cell-based CYP assays can simplify workload, save time and effort, and generate biologically relevant data. Cytochrome P450 (CYP) enzymes are key players in drug metabolism. Therefore, it is essential to understand how these enzymes can be affected by xenobiotics with regards to induction and toxicity to avoid potential drug–drug interactions. Typically, information has been gathered by combining data from multiple experiments, which is time-consuming and labor intensive, and interassay variability may lead to misinterpretation. Monitoring CYP induction and cytotoxicity by xenobiotics using an automated, multiplexed format can decrease workload and increase data confidence. Here the authors demonstrate the ability to monitor CYP1A and CYP3A4 induction, combined with a cytotoxicity measurement, from a single microplate well using cryopreserved human hepatocytes. The assay procedure was automated in a 384-well format, including cell manipulations, compound titration and transfer, and reagent dispensing, using simple robotic instrumentation. EC50 and Emax values were derived for multiple known CYP1A and -3A4 inducers. Induction and toxicological responses in the triplex system were validated based on literature values from conventional single-parameter assays. Validation and pharmacology data confirm that multiplexed cell-based CYP assays can simplify workload, save time and effort, and generate biologically relevant data.
MAGNUS — An ultra-high specific torque PM axial flux type motor with flux focusing and modulation (2017)

Axial flux permanent magnet (AFPM) synchronous motors are attractive for low speed direct drive systems because of their high specific torque. The present paper proposes a novel axial flux machine topology, called MAGNUS, obtained by combining a yokeless central stator type NS arrangement with two external high polarity spoke-rotors, resulting in very high flux concentration. The stator, which includes main and auxiliary teeth for air-gap profiling has a small number of concentrated coils. Two stator configurations are discussed, the first, a yokeless construction with coils wound around the teeth, and the second with coils placed around the stator core in a Gramme ring arrangement. Feasible slot pole combinations are identified. High torque densities are achievable owing to torque magnification achieved by air-gap profiling as well as flux concentration. Initial analysis indicates that this machine presents higher torque than a YASA machine, which currently holds a record for torque density.