gebhart/patrepeval huggingface dataset:
Tumour formation by single fibroblast growth factor receptor 3-positive rhabdomyosarcoma-initiating cells (2009)

Our findings suggest that rhabdomyosarcoma cell lines include a minor subpopulation of FGFR3-positive sarcoma-initiating cells, which can be maintained indefinitely in culture and which is crucial for their malignancy.
Maize lethal necrosis (MLN): Efforts toward containing the spread and impact of a devastating transboundary disease in sub-Saharan Africa (2020)

Maize lethal necrosis (MLN), a complex viral disease, emerged as a serious threat to maize production and the livelihoods of smallholders in eastern Africa since 2011, primarily due to the introduction of maize chlorotic mottle virus (MCMV). The International Maize and Wheat Improvement Center (CIMMYT), in close partnership with national and international partners, implemented a multi-disciplinary and multi-institutional strategy to curb the spread of MLN in sub-Saharan Africa, and mitigate the impact of the disease. The strategy revolved around a) intensive germplasm screening and fast-tracked development and deployment of MLN-tolerant/resistant maize hybrids in Africa-adapted genetic backgrounds; b) optimizing the diagnostic protocols for MLN-causing viruses, especially MCMV, and capacity building of relevant public and private sector institutions on MLN diagnostics and management; c) MLN monitoring and surveillance across sub-Saharan Africa in collaboration with national plant protection organizations (NPPOs); d) partnership with the private seed sector for production and exchange of MLN pathogen-free commercial maize seed; and e) awareness creation among relevant stakeholders about MLN management, including engagement with policy makers. The review concludes by highlighting the need to keep continuous vigil against MLN-causing viruses, and preventing any further spread of the disease to the major maize-growing countries that have not yet reported MLN in sub-Saharan Africa.
Supplemental Figure S4 from <i>KRAS</i> Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine (2023)

&lt;p&gt;A, CRAF-amplifed melanoma cancer cell line (A375) was pre-treated with decitabine (0.5 ÃŽÂ¼M) or DMSO for three, six or nine days followed by co-treatment of viable cells for three additional days with decitabine (0.5 ÃŽÂ¼M) or DMSO and small molecule inhibitors, GDC-0941, bortezomib or NVP-TAE684 (two biological replicates, mean {plus minus} SD). B, A375 cells were pre-treated as described above, followed by co-treatment with decitabine and navitoclax, trametinib or selumetinib for three additional days. Data is a representative example of two independent experiments.&lt;/p&gt;
ChemInform Abstract: Tetrazoles of Manno‐ and Rhamnofuranoses. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The interdisciplinary research of big data and wireless channel: A cluster-nuclei based channel model (2016)

Recently, internet stimulates the explosive progress of knowledge discovery in big volume data resource, to dig the valuable and hidden rules by computing. Simultaneously, the wireless channel measurement data reveals big volume feature, considering the massive antennas, huge bandwidth and versatile application scenarios. This article firstly presents a comprehensive survey of channel measurement and modeling research for mobile communication, especially for 5th Generation (5G) and beyond. Considering the big data research progress, then a cluster-nuclei based model is proposed, which takes advantages of both the stochastical model and deterministic model. The novel model has low complexity with the limited number of cluster-nuclei while the cluster-nuclei has the physical mapping to real propagation objects. Combining the channel properties variation principles with antenna size, frequency, mobility and scenario dug from the channel data, the proposed model can be expanded in versatile application to support future mobile research.
Genistein treatment duration effects biomarkers of cell motility in human prostate (2019)

Genistein inhibits pathways in human prostate that drive transformation to a lethal high motility phenotype. Long term treatment induces compensatory changes in biomarkers of efficacy. The current strategy of using such biomarkers after short term intervention as go/no-go determinants in early phase chemoprevention trials should be carefully examined.
Bezold-Jarisch Reflex Blunts Arterial Baroreflex via the Shift of Neural Arc toward Lower Sympathetic Nerve Activity (2004)

Although the Bezold-Jarisch (BJ) reflex is potentially evoked during acute myocardial ischemia or infarction, its effects on the static characteristics of the arterial baroreflex remain to be analyzed in terms of an equilibrium diagram between the neural and peripheral arcs. The neural arc represents the static input-output relationship between baroreceptor pressure input and efferent sympathetic nerve activity (SNA), whereas the peripheral arc represents that between SNA and arterial pressure (AP). In 8 anesthetized rabbits, we increased carotid sinus pressure stepwise from 40 to 160 mmHg in increments of 20 mmHg at one-minute intervals while measuring renal SNA and AP under control conditions and during the activation of the BJ reflex by intravenous administration of phenylbiguanide (PBG, 100 microg.kg(-1).min(-1)). The neural arc approximated a sigmoid curve whereas the peripheral arc approximated a straight line. PBG decreased AP at the operating point from -91.3 +/- 2.4 to -71.7 +/- 3.1 mmHg (P < 0.01), and attenuated the total loop gain at the operating point from -1.31 +/- 0.44 to -0.51 +/- 0.14 (P < 0.05). The equilibrium diagram indicated that PBG caused a parallel shift of the neural arc toward lower SNA such that the maximum SNA was reduced to approximately 60% of control. PBG decreased neural and peripheral arc gains at the operating point to approximately 43% and 77%, respectively. In conclusion, the BJ reflex blunts arterial baroreflex via the shift of the neural arc toward lower SNA.
Obinutuzumab for relapsed or refractory indolent non-Hodgkin’s lymphomas (2015)

The use of anti-CD20 monoclonal antibodies (mAbs), such as rituximab, in CD20-positive B-cell malignancies has dramatically improved the outcome of chronic lymphoid leukemia and non-Hodgkin's lymphomas (NHL). However, the occurrence of relapse and development of rituximab-refractory disease highlight the need to develop novel anti-CD20 mAbs, with improved mechanisms of action. Obinutuzumab is the first humanized type II glycoengineered anti-CD20 mAb. In vitro and in vivo data suggested several differences compared with rituximab, including a low level of complement-dependent cytotoxicity and an increased direct nonapoptotic cell death. Moreover, the glycoengineered Fc-linked nonfucosylated oligosaccharide enhanced the Fc-Fcγ receptor (FcγR) IIIa interaction, resulting in improved antibody-dependent cellular cytotoxicity and phagocytosis. Preclinical models suggested that these differences translate into superior survival in murine lymphoma models. Phase I/II trials in monotherapy in relapsed or refractory B-cell NHL demonstrated that obinutuzumab has an acceptable safety profile, infusion-related reactions being the most common adverse event. In rituximab-refractory indolent NHL, the recent randomized phase III GADOLIN study demonstrated an improved median progression-free survival for patients treated with obinutuzumab plus bendamustine rather than bendamustine alone. Further trials are ongoing to determine the role of obinutuzumab as a first-line agent in the treatment of follicular lymphoma.
Complete description of two-photon (1+1′) ionization of NO deduced from rotationally resolved photoelectron angular distributions (1991)

Time-of-flight photoelectron spectroscopy has been used to record energy-resolved photoelectron angular distributions (PADs) following (1+1′) resonance-enhanced multiphoton ionization (REMPI) of NO via the vi=1,Ni=22 rovibrational level of the A 2∑+ state. The PADs corresponding to single rotational states of the resulting molecular ion show a strong dependence on the change in ion core rotation ΔN(≡N+−Ni) and also on the angle between the linear polarization vectors of the two light beams. Broken reflection symmetry [I(θ,φ)≠I(−θ,φ)] is observed when the polarization vectors of the two light beams form an angle of 54.7°. A fit to the PADs provides a complete description of this molecular photoionization, namely, the magnitudes and phases of the radial dipole matrix elements that connect the intermediate state to the ‖lλ〉 photoelectron partial waves (Refs. 1 and 2). This information is then used to predict unobserved quantities, such as ion angular momentum alignment and the full three-dimensional form of the PADs.
LINQits (2013)

We present LINQits, a flexible hardware template that can be mapped onto programmable logic or ASICs in a heterogeneous system-on-chip for a mobile device or server. Unlike fixed-function accelerators, LINQits accelerates a domain-specific query language called LINQ. LINQits does not provide coverage for all possible applications---however, existing applications (re-)written with LINQ in mind benefit extensively from hardware acceleration. Furthermore, the LINQits framework offers a graceful and transparent migration path from software to hardware. LINQits is prototyped on a 2W heterogeneous SoC called the ZYNQ processor, which combines dual ARM A9 processors with an FPGA on a single die in 28nm silicon technology. Our physical measurements show that LINQits improves energy efficiency by 8.9 to 30.6 times and performance by 10.7 to 38.1 times compared to optimized, multithreaded C programs running on conventional ARM A9 processors.
3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound (2018)

Ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides, a reaction essential for DNA replication and repair. Human RNR requires two subunits for activity, the α subunit contains the active site, and the β subunit houses the radical cofactor. Here, we present a 3.3-Å resolution structure by cryo-electron microscopy (EM) of a dATP-inhibited state of human RNR. This structure, which was determined in the presence of substrate CDP and allosteric regulators ATP and dATP, has three α<sub>2</sub> units arranged in an α<sub>6</sub> ring. At near-atomic resolution, these data provide insight into the molecular basis for CDP recognition by allosteric specificity effectors dATP/ATP. Additionally, we present lower-resolution EM structures of human α<sub>6</sub> in the presence of both the anticancer drug clofarabine triphosphate and β<sub>2</sub>. Together, these structures support a model for RNR inhibition in which β<sub>2</sub> is excluded from binding in a radical transfer competent position when α exists as a stable hexamer.
Modular High-Power Shunt-Interleaved Drive System: A Realization up to 35 MW for Oil &#x00026; Gas Applications (2008)

The paper describes experimental results of a medium-voltage, modular, 35 MW drive for oil & gas applications realized by interconnecting voltage-source three-level converters equally sharing the motor current. Drives rated for tens of Megawatts are increasingly needed as torque helpers for gas turbines in the oil & gas industry and one envisions that they will replace them completely in the future. These drives must be very reliable, often capable of reversible power flow and high power quality when connected to weak grids in remote areas. The pronounced torsional eigenmodes of large compressors and gas turbines demand for very low torque harmonic content.
ChemInform Abstract: Diastereoselective Synthesis of β‐Substituted α‐Methylserines via Chelated Alanine Ester Enolates. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Decision-Theoretic Cooperative Parking for Connected Vehicles: an Investigation (2018)

In this paper, we investigate a cooperative car parking mechanism called CoPark-WS, for finding parking spaces in large areas. It is a decentralised approach which relies on vehicle-to-vehicle communications. There are two parameters we consider here in parking search behavior, namely, searching time and walking distance. The type of strategic cooperation and rational decision-making involved in selecting the search target areas in CoPark-WS are demonstrated via extensive simulations, which also show the robust performance of CoPark-WS in different circumstances.
In vitro and in vivo antitumor activity of immunoconjugates prepared by linking 5-fluorouridine to antiadenocarcinoma monoclonal antibody. (1997)

5-Fluorouridine (5-FUr), a cytotoxic antitumoral agent not in clinical use because of its systemic toxicity, and AR-3, a monoclonal antibody specific to a human colorectal adenocarcinoma, were covalently linked via two different strategies. 5-FUr was 5' succinilated after protection of the secondary hydroxyl groups and the carboxylate derivative was then activated as N-hydroxysuccinimidyl ester in order to react with the amino groups present in the monoclonal antibody, giving an amide linkage. Alternatively, a 5-FUr immunoconjugate containing an acid-cleavable hydrazone bond was formed from the reaction between an acyl hydrazide derivative of 5-FUr and a periodate oxydized antibody with approximately 12 aldehyde groups in its carbohydrate region. An average of 9 to 12 drug molecules were attached to the antibody. In a cytotoxic assay on the human colorectal carcinoma cell line HT-29, the hydrazone containing drug conjugate was equally active as the succinylamido conjugate and the free drug. However, ELISA showed that while in the case of the succinylamido conjugate the Mab immunoreactivity was not affected after conjugation, there was a significant loss of reactivity in the acid cleavable conjugate. In a model of a disseminated intraabdominal carcinomatosis by HT-29 intraperitoneal graft in nude mice, the 5-FUr immunoconjugate selected was more effective than the unconjugated drug in medium-term therapy (21 days after the graft and 16 days after drug treatment), albeit in the longer period the efficacy of the two formulations was similar. The toxic effect of the drug-conjugate in vivo was much weaker, demonstrating its clear advantage over the drug, in terms of pharmacological efficacy.
<title>Irregular grid volume rendering with composition networks</title> (1998)

Volumetric irregular grids are the next frontier to conquer in interactive 3D graphics. Visualization algorithms for rectilinear 256<SUP>3</SUP> data volumes have been optimized to achieve one frame/second to 15 frames/second depending on the workstation. With equivalent computational resources, irregular grids with millions of cells may take minutes to render for a new viewpoint. The state of the art for graphics rendering, PixelFlow, provides screen and object space parallelism for polygonal rendering. Unfortunately volume rendering of irregular data is at odds with the sort last architecture. I investigate parallel algorithms for direct volume rendering on PixelFlow that generalize to other compositing architectures. Experiments are performed on the Nasa Langley fighter dataset, using the projected tetrahedra approach of Shirley and Tuchman. Tetrahedral sorting is done by the circumscribing sphere approach of Cignoni et al. Key approaches include sort-first on sort-last, world space subdivision by clipping, rearrangeable linear compositing for any view angle, and static load balancing. The new world space subdivision by clipping provides for efficient and correct rendering of unstructured data by using object space clipping planes. Research results include performance estimates on PixelFlow for irregular grid volume rendering. PixelFlow is estimated to achieve 30 frames/second on irregular grids of 300,00 tetrahedra or 10 million tetrahedra per second.
Nonlinear dynamics of MEMS systems (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Kimberly L. Turner, Christopher Burgner, Zi Yie, Steven W. Shaw, Nicholas Miller; Nonlinear dynamics of MEMS systems. AIP Conf. Proc. 19 April 2011; 1339 (1): 111–113. https://doi.org/10.1063/1.3574849 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Multiline balanced SSFP for rapid functional imaging at ultrahigh field (2017)

We propose a multiline bSSFP for functional BOLD imaging that approaches the speed of echo-planar imaging and that shows an increased BOLD sensitivity compared with single-line bSSFP. Magn Reson Med 79:994-1000, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Prostate stem cells and benign prostatic hyperplasia (2008)

Pharmacological approaches are available to medically-managed patients with symptomatic BPH before surgical intervention is required. These include daily treatment with alpha-blockers and 5-alpha-reductase inhibitors alone or in combination. These medical approaches have two major problems. First, treatments are chronic and must be taken daily. Second, there are significant financial costs and quality of life issues for such chronic treatments. Is it possible to develop effective acute therapy for symptomatic BPH without the long-term androgen deprivation-induced side effects? Two seminal but rarely cited studies of Walsh [Peters, Walsh: N Engl J Med 317:599-604, 1987] and Coffey et al. [Sufrin et al.: Invest Urol 13:418-423, 1976], combined with the growing understanding of the stem cell organization of the prostate stromal (S) and epithelial (E) compartments and their reciprocal paracrine and autocrine interactions provides the rationale for an acute approach.The Walsh study documents that: (1) androgen deprivation disrupts the reciprocal interaction between the prostate S and E thereby decreasing the weight of both compartments and (2) once BPH develops, androgen deprivation does not decrease the number of stem cell units in either the S or E compartments since subsequent androgen restoration fully restores the enlarged gland. The Coffey study documents that acute androgen deprivation sensitizes S-E interactions to radiation induced disruptions so that following radiation, androgen restoration does not induce full gland regrowth. Therefore, effective therapy for symptomatic BPH should be achievable by acute treatment with reversible androgen deprivation for a limited period followed by a single dose of conformal external beam radiation before allowing the man to recovery his normal serum testosterone.
Efficient, Protecting Group Free Kilogram-Scale Synthesis of the JAK1 Inhibitor GDC-4379 (2021)

The development of an improved kilogram-scale synthesis of the JAK1 inhibitor GDC-4379 for the treatment of asthma is described. The new process is highlighted by a step-economical construction of a 3-substituted-4-aminopyrazole employing a telescoped oximation and hydrazine condensation of a 1,3-dielectrophile to generate nitrosopyrazole and a novel copper-catalyzed NaBH4 reduction of the nitroso group. The endgame process features an amidation of aminopyrazole with acid chloride under Schotten–Baumann conditions to provide access to the penultimate intermediate. A selective N-1 alkylation of the pyrazole moiety was accomplished under phase-transfer conditions, which delivered GDC-4379 with a defined particle-size distribution suitable for micronization after recrystallization and wet milling.
Safety and Immunogenicity of an HIV-1 Gag DNA Vaccine with or without IL-12 and/or IL-15 Plasmid Cytokine Adjuvant in Healthy, HIV-1 Uninfected Adults (2012)

Clinicaltrials.gov NCT00115960 NCT00111605.
Electrogram patterns predictive of successful catheter ablation of accessory pathways. Value of unipolar recording mode. (1991)

Some distinctive electrogram patterns concerning anterograde conduction are associated with success of accessory pathway fulguration. The unfiltered unipolar recording mode (PQS pattern) contributes significantly to optimizing the accuracy of accessory pathway localization.
Angiotensin‐converting enzyme inhibitors prevent liver‐related events in nonalcoholic fatty liver disease (2021)

ACEI, rather than ARB, treatment is associated with a lower risk of LREs in NAFLD patients, especially among those with CKD.
Catalyst‐Controlled Stereoselective Olefin Metathesis (2015)

This chapter covers the advances made since 2003 in the development of catalysts that can control the stereochemical outcome of olefin metathesis reactions. Various enantioselective processes, such as enantioselective ring-opening/cross-metathesis (EROCM) and enantioselective ring-closing metathesis (ERCM), promoted by chiral Mo or Ru complexes are discussed. A more recent development has been the introduction of complexes that can deliver the (often) higher-energy Z-alkene products selectively (vs. the typically thermodynamically favored E-alkenes generated by previous catalyst systems). The mechanistic basis and utility of different Mo, W and Ru complexes that can be utilized to access linear or macrocyclic Z-olefins is detailed. In all cases, the advantages and shortcomings of different catalyst classes (e.g., Mo/W alkylidenes vs. Ru carbenes as well as different types within each system) and their symbiotic relationships are presented. Whenever possible, applications to synthesis of natural products are discussed to underscore utility.
Borophene-graphene heterostructures (2019)

Integration of dissimilar two-dimensional (2D) materials is essential for nanoelectronic applications. Compared to vertical stacking, covalent lateral stitching requires bottom-up synthesis, resulting in rare realizations of 2D lateral heterostructures. Because of its polymorphism and diverse bonding geometries, borophene is a promising candidate for 2D heterostructures, although suitable synthesis conditions have not yet been demonstrated. Here, we report lateral and vertical integration of borophene with graphene. Topographic and spatially resolved spectroscopic measurements reveal nearly atomically sharp lateral interfaces despite imperfect crystallographic lattice and symmetry matching. In addition, boron intercalation under graphene results in rotationally commensurate vertical heterostructures. The rich bonding configurations of boron suggest that borophene can be integrated into a diverse range of 2D heterostructures.
An unexpected route for otolaryngology bacterial contamination with a Venturi atomizer (2014)

In ordinary otolaryngology practices, there are significant risks for bacterial contamination from the nasal vestibule to the tip of the Venturi atomizer even without direct contact. Clinicians must be more aware of this pattern of contamination, which has not been reported in the existing literature.