gebhart/patrepeval huggingface dataset:
OP03.19: Fetal ultrasound and magnetic resonance imaging in rhombencephalosynapsis (2006)

Rhomboencephalosynapsis (RES) is a rare, but increasingly recognized malformation consisting of fused cerebellar hemispheres, dentate nuclei and superior cerebellar peduncles and absent vermis. RES is associated with significant neurocognitive delay, seizures, and movement disorder. Associated central nervous system abnormalities are common. We report five fetal cases and discuss the fetal ultrasound and magnetic resonance imaging (MR) findings. All cases presented with hydrocephalus. Institutional ethics approval was obtained. Prenatal ultrasound is available in five cases, prenatal MR imaging in two, postnatal ultrasound and MR in two and autopsy confirmation in three. Images were evaluated for presence and degree of vermian fusion, presence of primary fissure and fastigial point and associated central nervous system anomalies. Fetal and postnatal MR readily identified the classic features of hypoplastic single lobed cerebellum with transverse folia and associated intracranial malformations, specifically within the realm of holoprosencephaly. Both also identified diamond shaped 4th ventricle on axial views, rounded ‘fastigial point’ and lack of primary fissure. Postnatal MR more readily identified fusion of the dentate nuclei. Fetal and postnatal ultrasound documented the transverse folia and narrow transverse diameter of the cerebellum. Rhomboencephalosynapsis is a rare lesion that is best imaged prenatally with fetal MR. Suspicious ultrasound features are cerebellar hypoplasia and absence of the vermis. The presence of these ultrasound findings should raise the clinical suspicion of RES, and be an indication for fetal MR if available.
Small Concentrations of oxLDL Induce Capillary Tube Formation From Endothelial Cells via LOX-1–Dependent Redox-Sensitive Pathway (2007)

These findings suggest that small concentrations of oxLDL promote capillary tube formation by inducing the expression of VEGF via LOX-1-mediated activation of NADPH oxidase- MAPKs-NF-kappaB pathway.
An Effective Unit Cell Approach to Compute the Thermal Conductivity of Composites With Cylindrical Particles (2003)

This paper introduces a novel method to model the effective thermal conductivity of cylindrical-particle-laden composite materials. This modeling methodology is a combination of the effective medium theory and the finite differences method. Typically the curvature effects of cylindrical or spherical particles are ignored while calculating the thermal conductivity of composites containing such particles through numerical techniques. These particles are modeled as cuboids or cubes. Numerical modeling of circular/spherical geometries as cubes or cuboids will lead to wrong conclusions due to two reasons: (i) It does not capture the effect of curvature on heat flow, i.e., constriction of heat flux lines near the particles due to shape, (ii) It assigns higher effective conductivity to the particles as the cubes or the cuboids have larger volume and surface area. An alternative approach to mesh the particles into small volumes is just about impossible as it leads to highly intensive computational algorithms to get accurate results. On the other hand, effective medium theory takes the effect of curvature into account but it cannot be used at high volume fractions because it does not take into account the effects of percolation. In this paper, a novel model is proposed where the cylindrical particles are still treated as squares (cuboids) but to capture the effect of curvature, an effective conductivity is assigned to the particles by using the effective medium approach. The authors call this the effective unit cell approach. Results from this model for different volume fractions, on average, have been found to lie within ±5% of experimental thermal conductivity data.
ChemInform Abstract: Photochemical Reduction of CpW(CO)3CH3 (Cp: η5‐C5H5) to CpW(CO)3‐; an Isolobal Analogy to the Disproportionation of Cp2Mo2(CO)6. (1986)

Abstract Irradiation of (I) in inert solvents in the presence of PPh3 gives (II) as the PPh3Me salt as well as the substitution product (III).
Data from The Discovery and Preclinical Development of ASG-5ME, an Antibody–Drug Conjugate Targeting SLC44A4-Positive Epithelial Tumors Including Pancreatic and Prostate Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Here, we report the development of an antibody–drug conjugate, ASG-5ME, which targets the solute carrier receptor SLC44A4. SLC44A4 is a member of a family of putative choline transporters that we show to be markedly upregulated in a variety of epithelial tumors, most notably prostate and pancreatic cancer. SLC44A4 is normally expressed on the apical surface of secretory epithelial cells, but in cancer we show expression is not restricted to the luminal surface in advanced and undifferentiated tumors. ASG-5ME consists of a human IgG2 anti-SLC44A4 antibody conjugated through a cleavable linker to the microtubule-disrupting agent monomethylauristatin E. It has potent antitumor activity in both cell line – and patient-derived xenograft models of pancreatic and prostate cancers. Combination studies with ASG-5ME and nab-paclitaxel demonstrated combination effect in both pancreatic and prostate tumor models. Altogether, the data presented here suggest that ASG-5ME may have the potential to offer a new therapeutic option for the treatment of pancreatic and prostate cancers. &lt;i&gt;Mol Cancer Ther; 15(11); 2679–87. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Emicizumab Prophylaxis Administered Once-weekly or Every Two Weeks Provides Effective Bleed Prevention in Persons with Hemophilia A (PwHA) without Inhibitors - Results from the Phase III HAVEN 3 Study (2019)

Objectives: Subcutaneous once-weekly (QW) prophylaxis with emicizumab - a bispecific humanized monoclonal antibody - is effective in PwHA with inhibitors. The HAVEN 3 (NCT02847637) study was designed to assess the efficacy, safety, and pharmacokinetics (PK) of emicizumab prophylaxis QW and every 2 weeks (Q2W) in adolescent/adult PwHA without inhibitors.
Nonparametric classification with polynomial MPMC cascades (2004)

A new class of nonparametric algorithms for high-dimensional binary classification is proposed using cascades of low dimensional polynomial structures. Construction of polynomial cascades is based on Minimax Probability Machine Classification (MPMC), which results in direct estimates of classification accuracy, and provides a simple stopping criteria that does not require expensive cross-validation measures. This Polynomial MPMC Cascade (PMC) algorithm is constructed in linear time with respect to the input space dimensionality, and linear time in the number of examples, making it a potentially attractive alternative to algorithms like support vector machines and standard MPMC. Experimental evidence is given showing that, compared to state-of-the-art classifiers, PMCs are competitive; inherently fast to compute; not prone to overfitting; and generally yield accurate estimates of the maximum error rate on unseen data.
Interest of synchronized pulsed plasmas for next CMOS technologies (2011)

International audience
Ripple II: faster communication through physical vibration (2016)

We envision physical vibration as a new modality of data communication. In NSDI 2015, our paper reported the feasibility of modulating the vibration of a smartphone's vibra-motor. When in physical contact with another smartphone, the accelerometer of the second phone was able to decode the vibrations at around 200 bits/s. This paper builds on our first prototype, but redesigns the entire radio stack to now achieve 30 kbps. The core redesign includes (1) a new OFDM-based physical layer that uses the microphone as a receiver (instead of the accelerometer), and (2) a MAC layer that detects collision at the transmitter and performs proactive symbol retransmissions. We also develop two example applications on top of the vibratory radio: (1) a finger ring that transmits vibratory passwords through the finger bone to enable touch based authentication, and (2) surface communication between devices placed on the same table. The overall system entails unique challenges and opportunities, including ambient sound cancellation, OFDM over vibrations, back-EMF based carrier sensing, predictive retransmissions, bone conduction, etc. We call our system Ripple II to suggest the continuity from the NSDI 2015 paper. We close the paper with a video demo that streams music as OFDM packets through vibrations and plays it in real time through the receiver's speaker.
A Synthetic Alternative to the Type-II Intramolecular 4 + 3 Cycloaddition Reaction (2003)

Oxyallyl cations generated in situ from dihaloketones have been found to undergo the Favorskii rearrangement in preference to an intramolecular Type-II 4 + 3 cycloaddition reaction in trifluoroethanol and hexafluoropropan-2-ol solvents, generating acrylate esters with high cis selectivity. A synthetic alternative to the intramolecular Type-II 4 + 3 cycloaddition has been developed on the basis of intramolecular enolate alkylation to close a 7-membered ring with an exocyclic double bond.
Epitaxial growth of light-responsive azobenzene molecular crystal actuators on oriented polyethylene films (2019)

We report on the epitaxial growth of photoresponsive alkyl-substituted azobenzene fibres on top of uniaxially oriented polyethylene (PE) films.
Slipped Capital Femoral Epiphysis (1996)

We reviewed 91 hips with slipped capital femoral epiphysis (SCFE) after an average follow-up period of 6 years 6 months. Different treatment methods used, according to types and stages of slipping, are discussed. In situ fixation appears to be the best procedure for SCFE with < 60% displacement. Careful reduction-fixation is indicated in acute and acute-on-chronic SCFE > 60%. Primary rotation osteotomies are associated with a high percentage of complications. Secondary osteotomies should be simple (preferably a subtrochanteric derotation osteotomy) to reduce the risk of necrosis. Preventive contralateral fixation is indicated when the growth cartilage is still open.
Direct Oxygenation of Benzene to Phenol Using Quinolinium Ions as Homogeneous Photocatalysts (2011)

Photocatalytic oxygenation of benzene with oxygen and water to phenol has been achieved under ambient conditions by using the 3-cyano-1-methylquinolinium ion as a photocatalyst (see picture). The mechanism was clarified by detecting the π-dimer benzene radical cation produced by photoinduced electron transfer from benzene to the photocatalyst, and by monitoring the reaction of the radical cations with water molecules. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: Kisspeptin‐10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism (2012)

Kisspeptin-10 administration increased LH pulse frequency and LH secretion in hypotestosteronaemic men with T2DM in this proof-of-concept study, with associated increases in serum testosterone. These data suggest a potential novel therapeutic role for kisspeptin agonists in enhancing endogenous testosterone secretion in men with T2DM and central hypogonadism.
Continuous flow photoassisted CO2 methanation (2017)

Photoassisted CO<sub>2</sub> methanation using Ni–Al<sub>2</sub>O<sub>3</sub>/SiO<sub>2</sub> as a photoresponsive catalyst has been carried out at 225 °C under continuous flow conditions achieving up to 3.5% conversion of CO<sub>2</sub> with complete selectivity to CH<sub>4</sub> under 2327 W m<sup>−2</sup> irradiation for a contact time of 1.3 s.
False positive endoscopic ultrasound fine needle aspiration cytology: incidence and risk factors (2010)

These findings refute the accepted paradigm that FP cytology rarely occurs with EUS FNA. Further investigation revealed that FP FNA developed secondary to endosonographer technique or initial cytological misinterpretation, and is particularly likely when perioesophageal or perirectal nodes are aspirated in the setting of a luminal neoplasm or Barrett's oesophagus. Further study is needed to determine the significance of these findings and potential impact on the performance of FNA and patient outcomes.
Enhanced optical nonlinearities in epitaxial quantum dots lasers on silicon for future photonic integrated systems (2021)

Four-wave mixing (FWM) is an important nonlinear optical phenomenon that underlines many of the discoveries and device applications since the laser was invented. Examples include parametric amplification, mode-locked pulses and frequency combs, and in the quantum optics regime, entangled-photon generation, squeezed-state production and optical transduction from the visible to infrared wavelengths. For quantum dot systems, the basic understanding of FWM is limited by the conventional investigation method, which concentrates on the FWM susceptibility measured with optical amplifiers. This paper addresses this weakness by performing laser experiments to account for all optical nonlinearities contributing to the FWM signal. Meanwhile, we gain valuable insight into the intricate interplay among optical nonlinearities. Using quantum dot lasers directly grown on silicon, we achieved FWM conversion efficiency sufficient to demonstrate self-mode-locking in a single-section laser diode, with sub-ps mode-locked pulse duration and kHz frequency-comb linewidth. A comparison with first-principles based multimode laser theory indicates measured FWM conversion efficiencies that are close to the theoretical limit. An advantage over earlier studies and crucial to confidence in the results are the quality and reproducibility of state-of-the-art quantum dot lasers. They make possible the detailed study of conversion efficiency over a broad parameter space, and the identification of the importance of p-doping. Systematic improvement based on our understanding of underlying physics will lead to transform limited performance and effective compensation of intrinsic and extrinsic effects, such as linewidth enhancement and background dispersion. The integration of FWM with lasing impacts numerous optoelectronic components used in telecom and datacom.
Photoelectrochemical liftoff of LEDs grown on freestanding c-plane GaN substrates (2016)

We demonstrate a thin-film flip-chip (TFFC) process for LEDs grown on freestanding c-plane GaN substrates. LEDs are transferred from a bulk GaN substrate to a sapphire submount via a photoelectrochemical (PEC) undercut etch. This PEC liftoff method allows for substrate reuse and exposes the N-face of the LEDs for additional roughening. The LEDs emitted at a wavelength of 432 nm with a turn on voltage of ~3 V. Etching the LEDs in heated KOH after transferring them to a sapphire submount increased the peak external quantum efficiency (EQE) by 42.5% from 9.9% (unintentionally roughened) to 14.1% (intentionally roughened).
Passives partitioning for single package single chip SoC on 32nm RFCMOS technology (2012)

Using a multilayer organic package substrate, we demonstrate that future system-on-chip with co-existing digital and radio integrated circuits can be partitioned to have critical RF inductors/transformers on package and active devices and capacitors on silicon, which enables cost and form factor reduction as well as design of radios on low resistivity substrate. As proof of concept, we present an example of silicon/package co-design, where a WLAN bandpass filter has been designed using 3D inductors on-package and multi-finger-capacitors on a 32nm silicon process. The design is validated both experimentally and through full wave electromagnetic simulation.
Toxicology of Gambierdiscus spp. (Dinophyceae) from Tropical and Temperate Australian Waters (2018)

Ciguatera Fish Poisoning (CFP) is a human illness caused by the consumption of marine fish contaminated with ciguatoxins (CTX) and possibly maitotoxins (MTX), produced by species from the benthic dinoflagellate genus <i>Gambierdiscus</i>. Here, we describe the identity and toxicology of <i>Gambierdiscus</i> spp. isolated from the tropical and temperate waters of eastern Australia. Based on newly cultured strains, we found that four <i>Gambierdiscus</i> species were present at the tropical location, including <i>G. carpenteri</i>, <i>G. lapillus</i> and two others which were not genetically identical to other currently described species within the genus, and may represent new species. Only <i>G. carpenteri</i> was identified from the temperate location. Using LC-MS/MS analysis we did not find any characterized microalgal CTXs (P-CTX-3B, P-CTX-3C, P-CTX-4A and P-CTX-4B) or MTX-1; however, putative maitotoxin-3 (MTX-3) was detected in all species except for the temperate population of <i>G. carpenteri.</i> Using the Ca<sup>2+</sup> influx SH-SY5Y cell Fluorescent Imaging Plate Reader (FLIPR) bioassay we found CTX-like activity in extracts of the unidentified <i>Gambierdiscus</i> strains and trace level activity in strains of <i>G. lapillus.</i> While no detectable CTX-like activity was observed in tropical or temperate strains of <i>G. carpenteri</i>, all species showed strong maitotoxin-like activity. This study, which represents the most comprehensive analyses of the toxicology of <i>Gambierdiscus</i> strains isolated from Australia to date, suggests that CFP in this region may be caused by currently undescribed ciguatoxins and maitotoxins.
Improved Margin in Long-Haul 40 Gb/s Systems Using Bit-Synchronously Modulated RZ-DQPSK (2006)

We demonstrated a substantial improvement in FEC margin at 40 Gb/s using bit-synchronously modulated RZ-DQPSK. We transmitted 28×40 Gb/s CRZ-DQPSK channels over 6,550 km with ~2 dB of actual FEC margin, without any PMD compensation.
Phase measurement in a collinear pump probe experiment: Application to molecular dynamics studies in liquids (1998)

We propose a novel approach of nonlinear resonant spectroscopy based on a collinear and degenerated pump probe experiment. This particular scheme leads to an oscillating time-resolved signal superimposed to the usual transient absorption signal. We have performed both amplitude and phase analysis of this oscillating signal as a function of the pump probe delay for different laser wavelengths. As an example, results on the resonantly excited dye molecule hexamethylindotricarbocyanine iodide (HITCI) in ethylene glycol at room temperature have been exploited in the framework of the phenomenological Brownian oscillator model. The corresponding numerical simulations have been carried out with a special emphasis on the phase sensitivity versus pump probe delay and detuning. The chromophore dynamical parameters obtained from phase variations of our signal are compared with other available spectroscopic studies.
Experiments on coherent multicode DS-CDMA (2002)

Direct sequence code division multiple access (DS-CDMA) is a promising candidate for 3rd generation mobile communications systems. We propose a coherent multicode DS-CDMA (CM-CDMA) scheme. The major features of the proposed access scheme are application of pilot symbol-aided coherent RAKE, traffic-adaptive transmit power control, orthogonal multicode transmission, and concatenated channel coding. A series of laboratory and field tests have been conducted. The measured results for the pilot symbol-aided coherent RAKE, transmit power control based on SIR measurements and multicode transmission are presented.
A high out-of-order issue symmetric superpipeline superscalar microprocessor (2002)

Due to technology's evolution, the number of transistors that can be integrated in a same chip has become, at the dawn of the 21st century, more than sufficient to implement simple superscalar cores. This excess, nowadays generally used for on-chip caches, can also be utilized to improve core's performances, but mainly to increase the core's superscalarness degree. Although it now seems that a high degree is not justified, it could become useful in the future with progress in compilation. Setting out from this observation, we describe a new superscalar architecture with a high out-of-order issue rate. This architecture implements, in particular, precise interrupt management and multiple branch prediction. Furthermore, the architecture's specification has taken into account the aspect of hardware implementation, and thus, temporal matching of pipeline's stages. We therefore assist to a finer partitioning of this pipeline, hence the additional superpipeline label.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ChemInform Abstract: One‐Pot Synthesis of Isoquinolinium Salts by Rhodium‐Catalyzed C—H Bond Activation: Application to the Total Synthesis of Oxychelerythrine (XII). (2012)

Abstract Various substituted isoquinolinium salts are available by coupling of aromatic aldehydes with internal alkynes and primary amines under conditions A).
O-H Chemical Shift, Conformation, and Electron Delocalization in Protonated Carbonyl Compounds (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTO-H Chemical Shift, Conformation, and Electron Delocalization in Protonated Carbonyl CompoundsM. Brookhart, G. C. Levy, and S. WinsteinCite this: J. Am. Chem. Soc. 1967, 89, 7, 1735–1737Publication Date (Print):March 1, 1967Publication History Published online1 May 2002Published inissue 1 March 1967https://pubs.acs.org/doi/10.1021/ja00983a039https://doi.org/10.1021/ja00983a039research-articleACS PublicationsRequest reuse permissionsArticle Views281Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Data from A Multigene Assay Is Prognostic of Survival in Patients with Early-Stage Lung Adenocarcinoma (2023)

Supplementary Data from A Multigene Assay Is Prognostic of Survival in Patients with Early-Stage Lung Adenocarcinoma
<title>Fabrication of rare-earth-doped optical fiber</title> (1991)

Optical fibers may be doped with rare earth ions using several methods. While bulk methods such as rod-in-tube may be employed low-loss fiber requires adaptations of standard fiber fabrication processes namely modified chemical vapor deposition and vertical axial deposition. After discussion of these variations some design issues related to optical amplifiers are discussed.