gebhart/patrepeval huggingface dataset:
Preferred product attributes of a multipurpose vaginal ring: Findings from a phase 1 trial (2023)

Study findings suggest that a multipurpose IVR would make a valuable contribution to women's sexual and reproductive health options, and that both continuous and interrupted use strategies may be preferred.
Enhanced Capillary Formation Stimulated by a Chimeric Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor-C Silk Domain Fusion Protein (2007)

Vascular endothelial growth factor (VEGF)-C and VEGF-D require proteolytic cleavage of the carboxy terminal silk-homology domain for activation. To study the functions of the VEGF-C propeptides, we engineered a chimeric growth factor protein, VEGF-CAC, composed of the amino- and carboxy-terminal propeptides of VEGF-C fused to the receptor-activating core domain of VEGF. Like VEGF-C, VEGF-CAC underwent proteolytic cleavage, and like VEGF, it bound to and activated VEGF receptor-1 and VEGF receptor-2, but not the VEGF-C receptor VEGF receptor-3. VEGF-CAC also bound to neuropilins in a heparin-dependent manner. Strikingly, when VEGF-CAC was expressed via an adenovirus vector in the ear skin of immunodeficient mice, it proved to be a more potent inducer of capillary angiogenesis than VEGF. The VEGF-CAC-induced vessels differed greatly from those induced by VEGF, as they formed a very dense and fine network of pericyte and basement membrane-covered capillaries that were functional, as shown by lectin perfusion experiments. VEGF-CAC could prove useful in proangiogenic therapies in patients experiencing tissue ischemia.
Probing the Interaction of HTI-286 with Tubulin Using a Stilbene Analogue (2004)

HTI-286 is a synthetic analogue of the natural product hemiasterlin. HTI-286 is a potent antitumor agent that induces tubulin oligomerization. To investigate the binding stoichiometry and the binding site during this ligand-induced tubulin association, we synthesized an analogue of HTI-286 containing the chromophore stilbene. Using the distinct absorbance of the stilbene analogue, we determined the amounts of inhibitors bound to different tubulin oligomers by analytical ultracentrifugation. Herein we describe our findings based on these experiments. At the ratio of inhibitor to protein equal to or greater than 1, the stilbene analogue induces oligomerization of tubulin to a ring structure. The binding stoichiometry in the ring is one inhibitor per tubulin monomer (defined as an alpha/beta-heterodimer). At the ratio of inhibitor to protein less than 1, tubulin forms multiple intermediates, with the binding stoichiometry less than one inhibitor per tubulin monomer for all intermediates. The stable complex between the inhibitor and tubulin monomer was not detected under our experimental conditions. The binding site of the stilbene analogue does not overlap with the classic tubulin-binding agent, colchicine.
Towards approaching near-optimal MIMO detection performance ONAC-programmable baseband processor (2014)

Lattice Reduction aided softoutput MIMO detectors have been demonstrated to offer a promising gain. However, computing Log-Likelihood ratios (LLR) for near-optimal MIMO detection, still poses a significant challenge for practical implementations. In this work, we present counter-ML bit-flipping algorithm for LLR generation. The proposed LLR generation algorithm has been designed to take advantage of the previously reported list generation algorithm, Multi-Tree Selective Spanning (MTSS), by maximizing the reuse of computations. Afterwards, a C-programmable MIMO detector architecture providing both data level parallelism (DLP) and instruction level parallelism (ILP), is designed for implementation. The proposed solution supports multiple MIMO detection modes, with both hard and softoutput. Performance of the proposed solution can be tuned ranging from SIC to near-ML to near-MAP, by adjusting a single parameter. In case of 4 × 4 QAM-64, it achieves peak-throughputs of 2.43Gbps and 629Mbps in case of hard and softoutput MIMO detection, with only 66.37mW and 76.14mW respective power consumption.
Organotin nucleophiles. 6. Palladium-catalyzed allylic etherification with tin alkoxides (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganotin nucleophiles. 6. Palladium-catalyzed allylic etherification with tin alkoxidesEhud Keinan, Mahendra Sahai, Zeev Poth, Abraham Nudelman, and Jacob HerzigCite this: J. Org. Chem. 1985, 50, 19, 3558–3566Publication Date (Print):September 1, 1985Publication History Published online1 May 2002Published inissue 1 September 1985https://pubs.acs.org/doi/10.1021/jo00219a023https://doi.org/10.1021/jo00219a023research-articleACS PublicationsRequest reuse permissionsArticle Views751Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Assembly of Gold Nanostructured Films Templated by Colloidal Crystals and Use in Surface-Enhanced Raman Spectroscopy (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTAssembly of Gold Nanostructured Films Templated by Colloidal Crystals and Use in Surface-Enhanced Raman SpectroscopyPeter M. Tessier, Orlin D. Velev, Anand T. Kalambur, John F. Rabolt, Abraham M. Lenhoff, and Eric W. KalerView Author Information Department of Chemical Engineering and Department of Materials Science and Engineering University of Delaware, Newark, Delaware 19716 Cite this: J. Am. Chem. Soc. 2000, 122, 39, 9554–9555Publication Date (Web):September 16, 2000Publication History Received26 June 2000Revised18 August 2000Published online16 September 2000Published inissue 1 October 2000https://pubs.acs.org/doi/10.1021/ja0022831https://doi.org/10.1021/ja0022831rapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views3104Altmetric-Citations315LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amorphous materials,Crystals,Gold,Metal nanoparticles,Nanoparticles Get e-Alerts
15 W AlGaN/GaN Heterojunction FET on Sapphire Substrate (2001)

AlGaN/GaN heterojunction FETs (HJFETs) on a thinned sapphire substrate are demonstrated with improved power capability. A 16 mm wide unpassivated HJFET on a 50 μm thick sapphire demonstrated 15.9 W cw saturated output power, 9.0 dB linear gain, and 29.1% power-added efficiency (PAE) at 34 V drain bias. Also, an 8 mm wide SiN-passivated HJFET on a 50 μm thick sapphire exhibited 11.9 W cw saturated output power, 13.3 dB linear gain, and 49.7% PAE at 26 V drain bias. The 15.9 W result is the highest total power achieved for GaN FETs on sapphire, establishing the validity of the GaN-on-thinned-sapphire technology.
Stationary reference frame sensorless vector control based on primary flux linkage and sinusoidal complete tracking current controller for IPMSM (2015)

This paper proposes a sensorless vector control method based on Primary flux linkage and sinusoidal current tracking control for Interior permanent magnet synchronous motor. The proposed sensorless vector control can control torque at different speeds. Furthermore, the proposed sensorless vector control method estimates the primary flux linkage vector. At various speeds, it is possible to control the torque without relying on position or speed information.
Optoelectronic Parametric Amplification in a Microstrip Ring Resonator on GaAs Substrate (1997)

Nonlinear interaction between an optically modulated RF input and a microwave LO (local oscillator) in a nonlinear microstrip ring resonator on a semi-insulating GaAs (gallium arsenide) substrate is investigated. When the capacitive reactance of the detector is modulated, a parametric amplification effect of the mixer occurs. In this device structure, a parametric amplification gain of 10 dB without applied bias in the RF signal is obtained. This microwave optoelectronic mixer can be used in fiber-optic communication links.
In-situ measurement of solid phase transformations during dissolution testing (2006)

To combine in-situ solid phase analysis with intrinsic dissolution rate (IDR) measurements in order to achieve real-time molecular level information of solid phase behavior of APIs during dissolution testing. KEY FINDINGS The solid phase behavior cannot always be reliably derived from the IDR curve. However, with in-situ solid phase analysis, direct information on possible solid phase changes can be obtained. As a result, a deeper understanding of the phenomena related to overall dissolution is achieved.
Silicon photonics transceivers for high speed optical interconnect (2015)

In this paper we address key design and performance aspects of high-speed optical transceivers based on silicon photonics technology.
A new technique for adaptive scalar quantization of image sub-band coefficients (2002)

A new method for adaptive scalar quantization of image sub-band coefficients has been developed. This method is based on a phase dispersion technique originally developed for the design of pulse compression radar signals. For this method, the coefficient magnitudes and signs are coded separately. The magnitudes are scanned into a set of 1-D same orientation, cross-band vectors. Each vector is processed using a non-linear transformation. The result of this operation is a vector whose components are approximately identically distributed. Therefore, only one quantizer and one entropy coder are needed to code each vector. The technique offers the performance of a fully adaptive compression scheme, but with modest overhead and computational requirements. This paper provides an overview of the method as well as experimental results obtained through simulation.
Properties of Waterborne Polyurethane/Clay Nanocomposite Adhesives with Various Countercations of Carboxyl Acid Salt Group (2010)

Four series of waterborne polyurethane (WBPU)/clay nanocomposite adhesives were prepared using three different countercations, namely triethylamine (TEA), lithium hydroxide (LiOH) and copper hydroxide (Cu(OH)2 ) as well as one mixed countercation of TEA and Cu(OH)2 (1:0.5). The interaction of carboxyl acid salt group using different countercations with clay platelet was characterized by SEM and TEM, and the interaction effects on properties such as water swelling (%), thermal stability, tensile strength, glass transition temperature ( T g ), and adhesive strength were investigated. The tensile strength, water resistance and adhesive strength increased with increasing clay content up to an optimal value at which point the maximum tensile strength, water resistance and adhesive strength were recorded for each series. However, the optimal clay contents were 1.00 and 0.50 wt% for TEA/LiOH mixed countercation series and (Cu(OH)2 ) series, respectively. Among all of the samples the maximum tensile strength, water resistance and adhesive strength were found using mixed countercation (TEA and Cu(OH)2 = 1:0.5) with 1 wt% clay content.
Activation of Sarm1 produces cADPR to increase intra-axonal calcium and promote axon degeneration in CIPN (2021)

SUMMARY Cancer patients frequently develop chemotherapy-induced peripheral neuropathy (CIPN), a painful and long-lasting disorder with profound somatosensory deficits. There are no effective therapies to prevent or treat this disorder. Pathologically, CIPN is characterized by a “dying-back” axonopathy that begins at intra-epidermal nerve terminals of sensory neurons and progresses in a retrograde fashion. Calcium dysregulation constitutes a critical event in CIPN, but it is not known how chemotherapies such as paclitaxel alter intra-axonal calcium and cause degeneration. Here, we demonstrate that paclitaxel triggers Sarm1-dependent cADPR production in distal axons, promoting intra-axonal calcium flux from both intracellular and extracellular calcium stores. Genetic or pharmacologic antagonists of cADPR signaling prevent paclitaxel-induced axon degeneration and allodynia symptoms, without mitigating the anti-neoplastic efficacy of paclitaxel. Our data demonstrate that cADPR is a calcium modulating factor that promotes paclitaxel-induced axon degeneration and suggest that targeting cADPR signaling provides a potential therapeutic approach for treating CIPN. HIGHLIGHTS Paclitaxel induces intra-axonal calcium flux Sarm1-dependent cADPR production promotes axonal calcium elevation and degeneration Antagonizing cADPR signaling pathway protects against paclitaxel-induced peripheral neuropathy in vitro and in vivo
Statistical Inference for Pareto Distribution based on Progressive Type-I Hybrid Censoring Scheme (2017)

In this paper, the maximum likelihood and Bayesian estimations are developed based on progressive Type-I hybrid censored sample from the Pareto distribution. The Bayesian estimators for the unknown parameters are computed using the squared error loss function. Also, the point and interval Bayesian predictions for the unobserved failures from the same sample and that from the future sample are derived. Moreover, a Monte Carlo simulation study is carried out to compare the performance of the maximum likelihood and the Bayesian estimators. Finally, numerical example is presented for illustrating all the inferential procedures developed here.
Clinical informatics training in medical school education curricula: a scoping review (2022)

The literature reveals that CI training in the core curricula will complement if not enhance clinical skills, reiterating the need to equip students with relevant CI competencies. Furthermore, future research needs to comprehensively address current gaps in CI training in different contexts, evaluation methodologies, and delivery modes to facilitate structured training.
Deferasirox, an Iron-Chelating Agent, as Salvage Therapy for Rhinocerebral Mucormycosis (2006)

Deferasirox, an Iron-Chelating Agent, as Salvage Therapy for Rhinocerebral Mucormycosis ᰔIron availability is a critical factor in the growth of Mucorales ( 5).Here we report the novel use of deferasirox (Exjade; Novartis), an iron chelator recently approved by the U.S. Food and Drug Administration for the treatment of transfusionrelated iron overload (3), as salvage therapy for a patient with progressive rhinocerebral mucormycosis.
Serum 25-hydroxy vitamin D concentration in acute coronary syndrome. (2017)

Vitamin D may have prognostic value in cardiovascular disease (CVD) patients and, in addition to conventional biomarkers, could be a valuable tool for disease management. The aim of this study was to assess the association of vitamin D status in patients with acute coronary syndrome (ACS) and to evaluate its prognostic utility. The levels of 25(OH) vitamin D were correlated with troponin T hs. Forty-eight consecutive outpatients (40 Caucasian and 8 Asian) aged between 40 and 70 years (mean 61.5, range 43-77 years) were enrolled in the study. All patients were admitted to the Emergency Department with chest pain and suspected ACS. The main exclusion criteria were age <18 years, kidney failure, onco-haematological disease, hypo-hyperparathyroidism, hypo/hyperthyroidism, osteoporosis, treatment with bisphosphonate or 25(OH) vitamin D supplementation. Of the 48 subjects included in the study, thoracic pain symptoms were described in 12 patients with unstable angina (UA) and in 6 patients with ST elevation myocardial infarction (STEMI) and in 30 patients with non-ST-elevation myocardial infarction (NSTEMI). Low 25(OH) vitamin D levels correlated with the presence of ACS (p< 0.02) and inversely correlated with Troponin T hs (TnT hs) levels (p< 0.03). The determination of 25(OH) vitamin D levels in combination with TnT hs could improve the research for possible underlying conditions, and these should be managed meticulously according to current guidelines.
Two-Photon Excitation of Fluorogenic Probes for Redox Metabolism:  Dramatic Enhancement of Optical Contrast Ratio by Two-Photon Excitation (2007)

Fluorogenic probes for redox metabolism are shown to exhibit two-photon absorption using femtosecond pulses from a Ti/sapphire laser. The probes consist of a coumarin or naphthalene core and a ketone−alcohol functional group. The probe design is based on the changes in fluorescence properties and two-photon cross section values when the ketone derivative is reduced to the corresponding alcohol. The resulting contrast ratio of the fluorescence differs significantly from that obtained by one-photon excitation. This phenomenon was demonstrated with all three switches examined herein and represents an attractive approach to modulation of emission properties of molecular switches. The practical applicability of the two-photon-excitation redox switch was demonstrated in an enzyme-catalyzed transformation. The nonfluorescent probe 1 is efficiently converted by AKR1C3, a human 3α-hydroxysteroid dehydrogenase, to the fluorescent derivative 2. Using two-photon excitation (775 nm), we achieved a large contrast ratio between the fluorescence in the presence and the absence of the enzyme of ∼300.
Changepoint Detection on a Graph of Time Series (2023)

When analysing multiple time series that may be subject to changepoints, it is sometimes possible to specify a priori, by means of a graph, which pairs of time series are likely to be impacted by simultaneous changepoints. This article proposes an informative prior for changepoints which encodes the information contained in the graph, inducing a changepoint model for multiple time series that borrows strength across clusters of connected time series to detect weak signals for synchronous changepoints. The graphical model for changepoints is further extended to allow dependence between nearby but not necessarily synchronous changepoints across neighbouring time series in the graph. A novel reversible jump Markov chain Monte Carlo (MCMC) algorithm making use of auxiliary variables is proposed to sample from the graphical changepoint model. The merit of the proposed approach is demonstrated through a changepoint analysis of computer network authentication logs from Los Alamos National Laboratory (LANL), demonstrating an improvement at detecting weak signals for network intrusions across users linked by network connectivity, whilst limiting the number of false alerts.
Geographic routing without location information (2003)

For many years, scalable routing for wireless communication systems was a compelling but elusive goal. Recently, several routing algorithms that exploit geographic information (e.g. GPSR) have been proposed to achieve this goal. These algorithms refer to nodes by their location, not address, and use those coordinates to route greedily, when possible, towards the destination. However, there are many situations where location information is not available at the nodes, and so geographic methods cannot be used. In this paper we define a scalable coordinate-based routing algorithm that does not rely on location information, and thus can be used in a wide variety of ad hoc and sensornet environments.
(S)‐4‐Amino‐5‐phenoxypentanoate designed as a potential selective agonist of the bacterial transcription factor GabR (2020)

Addressing molecular recognition in the context of evolution requires pursuing new molecular targets to enable the development of agonists or antagonists with new mechanisms of action. Disruption of transcriptional regulation through targeting transcription factors that regulate the expression of key enzymes in bacterial metabolism may provide a promising method for controlling the bacterial metabolic pathways. To this end, we have selectively targeted a bacterial transcription regulator through the design and synthesis of a series of γ-aminobutyric acid (GABA) derivatives, including (S)-4-amino-5-phenoxypentanoate (4-phenoxymethyl-GABA), which are based on docking insights gained from a previously-solved crystal structure of GabR from Bacillus subtilis. This target was selected because GabR strictly controls GABA metabolism by regulating the transcription of the gabT/D operon. These GabR transcription modulators are selective for the bacterial transcription factor GabR and are unable to bind to structural homologs of GabR due to distinct steric constraints. We have obtained a crystal structure of 4-phenoxymethyl-GABA bound as an external aldimine with PLP in the effector binding site of GabR, which suggests that this compound is capable of binding and reacting in the same manner as the native effector ligand. Inhibition assays demonstrate high selectivity of 4-phenoxymethyl-GABA for bacterial GabR versus several selected eukaryotic enzymes. Single-molecule fluorescence resonance energy transfer (smFRET) experiments reveal a ligand-induced DNA distortion that is very similar to that of the native effector GABA, suggesting that the compound functions as a potential selective agonist of GabR.
Comparison of tumor microvasculature assessment via Ultrafast Doppler Tomography and Dynamic Contrast Enhanced Ultrasound (2014)

Assessing structural organization and dynamics of tumor blood supply is of highest interest since numerous cancer treatments rely on antiangiogenic effects. Dynamic Contrast Enhanced Ultrasound (DCE-US) is widely used in cancer research to extract quantitative parameters reflecting tumor perfusion. However, the underlying vascular structure is not revealed and local spatial fluctuations in DCE parametric maps remain unexplained. The recently introduced Ultrafast Doppler Tomography (UFD-T) has been shown able to reconstruct the 3D vascular network of a rat brain with a 100μm resolution. It is applied here to tumor vasculature imaging and quantitative hemodynamics assessment along with DCE-US to show the complementarity between the techniques.
Spinal Lordosis With Marked Opisthotonus Secondary to Dystonia Musculorum Deformans (2001)

Dystonia musculorum deformans is a rare condition resulting in coronal or sagittal plane deformities. When other treatment methods are unsuccessful, surgical instrumentation and arthrodesis may correct the deformity and improve function.
Laser Superintensi per tutti (2007)

Nuove facilities nazionali ed europeee per la produzione di impulsi laser ad altissime intensitaÁ aprono\n\nprospettive interdisciplinari tra la fisica della materia e la fisica del nucleo, delle particelle e delle interazioni\n\nfondamentali.
Multi-Band OFDM versus Single-Carrier DP-QPSK for 100 Gbps Long-Haul WDM Transmission (2012)

International audience