gebhart/patrepeval huggingface dataset:
A Building Block IC for Designing Emerging Hybrid and Multilevel Converters (2017)

This paper introduces a practical power management integrated circuit (IC) building block, i.e., IC module, which enables the implementation of various emerging hybrid and multilevel power converter topologies in low-power highfrequency applications, operating at switching frequencies up to 10 MHz. Compared to conventional buckand boost-based topologies, the emerging multilevel and hybrid converters offer significant volume reduction and power processing efficiency improvements. These key factors are significant contributions for modern portable and/or small footprint electronics devices, where size is of great concern. The IC building block (ICBB) consists of two segmented half bridges as well as all the elements needed for implementing mixed-signal current programmed mode (CPM) control. Mixed-signal CPM compatibility coupled with a segmented power stage not only provide inherent current protection and simple controller implementation but also allows for dynamic efficiency optimization. Operation at high-switching frequencies and simple modular design with ICBB are enabled through the development of novel architectures for key functional blocks of the ICBB and a cost-effective solution for level shifting, providing communication between external control signals and module inputs. For example, solutions for high-frequency low-power current sensing and fast digital-to-analog conversion are introduced as well as a capacitive coupling and coding schemes for data transfer. Several identical custom-designed ICBB modules are fabricated in the 0.13-μm CMOS process, each providing up to 2 W of output power, while operating at a switching frequency of up to 10 MHz. The versatility and proper functionality of these modules are verified through simulation and experimental results.
Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin (2019)

The function of small G protein signalling modulators (SGSM1/2/3) in cancer remains unknown. Our findings demonstrated that SGSM2 is a plasma membrane protein that strongly interacted with E-cadherin/β-catenin. SGSM2 downregulation enhanced the phosphorylation of focal adhesion kinase (FAK; Y576/577), decreased the expression of epithelial markers such as E-cadherin, β-catenin, and Paxillin, and increased the expression of Snail and Twist-1, which reduced cell adhesion and promoted cancer cell migration. Oestrogen and fibronectin treatment was found to promote the colocalization of SGSM2 at the leading edge with phospho-FAK (Y397). The BioGRID database showed that SGSM2 potentially interacts with cytoskeleton remodelling and cell-cell junction proteins. These evidences suggest that SGSM2 plays a role in modulating cell adhesion and cytoskeleton dynamics during cancer migration.
Frequency and significance of post-intubation hypotension during emergency airway management (2011)

Arterial hypotension is known to follow emergency intubation but the significance of this event is poorly described. We aimed to measure the incidence of post-intubation hypotension (PIH) following emergency intubation and determine its association with in-hospital mortality.
Xenobiotic Induced Expression of Epsilon Glutathione S – Transferases Gste2 In Laboratory Strains of Anopheles Arabiensis (2019)

Over expression of GSTe2 has been associated with resistance to DDT in An . arabiensis. The expression of the gene was induced by exposing the fourth instar larvae obtained from KGB and MAT strains to xenobiotic inducers. Transcripts levels of GSTe2 in cDNAs of the larvae from each strain was measured by quantitative PCR at various time points post exposure to DDT, permethrin and hydrogen peroxide. Statistical analysis was used to test for differences and compare the expression of the gene between treatments and mosquito strains. The geometric mean expression levels of GSTe2 induced at one hour by DDT in the KGB was 1.028 (CI 0.901~1.172; p < 100) compared to 0.587 (CI 0.475~0.724; p = 0.025) in MAT strain. Higher induction of GSTe2 in KGB was caused by DDT and hydrogen peroxide and with permethrin and DDT in MAT strain. Further research is needed to understand the molecular mechanisms regulating response of An. arabiensis to xenobitics.
Micropores-in-macroporous gel polymer electrolytes for alkali metal batteries (2019)

Micropores-in-macroporous polymer membranes containing an immobilized-liquid electrolyte enable dendrite-free alkali metal batteries.
Efficient Leaky-Wave Antenna for Terahertz Wireless Communications (2021)

We study the radiation properties of leaky-wave antenna at terahertz frequencies for wireless communications. We introduce a novel aperture design that increase the efficiency and directionality of the generated beams.
Invited Presentation: Cabon Nanotube Terahertz Detector (2014)

We present a macroscopic terahertz detector based on optically thick films of dense and aligned carbon nanotubes. This p-n junction detector responds to a broad range of frequencies, shows a response at zero bias, good linearity with THz power, and is intrinsically sensitive to polarization. A combination of electrical, thermal, opto-thermal, and thermoelectric experiments establishes the photothermoelectric mechanism of the response.
Surface-Enhanced Raman Spectroscopy: Using Nanoparticles to Detect Trace Amounts of Colorants in Works of Art (2016)

In recent years, powerful physical processes occurring in the vicinity of nanoscale metal surfaces have been exploited in the art world for the detection of trace amounts of colorants with surface-enhanced Raman spectroscopy (SERS). With this technique, naturally occurring and man-made organic molecules used as dyes and pigments in objects from antiquity to the present day are being detected with high molecular specificity and unprecedented sensitivity. This chapter reviews the broad spectrum of SERS analytical methodologies and instrumental improvements that have been developed over the years in the field of cultural heritage science, and discusses significant case studies within different types of works of art and archaeological artifacts.
3D Reconstruction of the Magnetic Vector Potential using Model Based Iterative Reconstruction (2017)

Lorentz Transmission Electron Microscopy (TEM) observations of magnetic nanoparticles contain information on the magnetic and electrostatic potentials. Vector Field Electron Tomography (VFET) can be used to reconstruct electromagnetic potentials of the nanoparticles from their corresponding LTEM images. The VFET approach is based on the conventional filtered back projection approach to tomographic reconstructions and the availability of an incomplete set of measurements due to experimental limitations means that the reconstructed vector fields exhibit significant artifacts. In this paper, we outline a model-based iterative reconstruction (MBIR) algorithm to reconstruct the magnetic vector potential of magnetic nanoparticles. We combine a forward model for image formation in TEM experiments with a prior model to formulate the tomographic problem as a maximum a-posteriori probability estimation problem (MAP). The MAP cost function is minimized iteratively to determine the vector potential. A comparative reconstruction study of simulated as well as experimental data sets show that the MBIR approach yields quantifiably better reconstructions than the VFET approach.
Characterization of crystallographic properties and defects via X‐ray microdiffraction in GaN (0001) layers (2006)

Abstract Intrinsic stresses due to lattice mismatch, high densities of threading dislocations, and extrinsic stresses resulting from the mismatch in the coefficients of thermal expansion, are present in almost all III‐Nitride heterostructures. Stress relaxation in the GaN layers occurs in conventional, cantilever (CE) and in pendeo‐epitaxial (PE) films via the formation of additional misfit dislocations, domain boundaries, elastic strain and wing tilt. Polychromatic X‐ray microdiffraction, high resolution monochromatic X‐ray diffraction and SEM analysis have been used to determine the crystallographic properties, misfit dislocations distribution and crystallographic tilts in uncoalesced GaN layers grown by PE and CE. The crystallographic tilt between the GaN(0001) and Si(111) planes was detected in the CE grown samples on Si(111). In contrast there was no tilt between GaN(0001) and SiC(0001) planes in PE grown samples. The wings are tilted upward for both the PE and CE grown uncoalesced GaN layers. (© 2006 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Metallization contacts to nonpolar a-plane n-type GaN (2008)

We have investigated the electrical characteristics of metallization contacts to nonpolar a-plane and polar c-plane n-type GaN. Pd Schottky diodes and x-ray photoemission spectroscopy measurements show that the Schottky barrier height of the a-plane GaN is lower than that of the c-plane GaN by 0.24 and 0.30eV, respectively. Ti∕Al Ohmic contacts to the a-plane n-GaN produce lower contact resistivity than that of the c-plane samples when annealed at 500°C. However, Ti∕Al contacts to the c-plane and a-plane GaN show opposite electrical behavior when annealed at temperatures above 500°C, which is attributed to the absence of polarization-induced surface charges for a-plane GaN.
Evaluation of 64Cu-Labeled New Anti-EGFR Antibody NCAB001 with Intraperitoneal Injection for Early PET Diagnosis of Pancreatic Cancer in Orthotopic Tumor-Xenografted Mice and Nonhuman Primates (2021)

Objectives: To improve the prognosis of pancreatic cancer, new imaging methods to identify tumor lesions at a size of &lt;1 cm are urgently needed. To approach this clinical issue, we developed a new method to detect small tumor lesions in the pancreas (≥3 mm) by positron emission tomography (PET) using an intraperitoneally (ip)-administered 64Cu-labeled new anti-epidermal growth factor receptor (EGFR) antibody (encoded as NCAB001), called 64Cu-NCAB001 ipPET. Methods: NCAB001 was manufactured under cGMP conditions and labeled with 64Cu. The radiochemical and biological properties of 64Cu-NCAB001 were evaluated. Tumor uptake of an ip-administered 64Cu-NCAB001 in mice with orthotopic pancreatic tumor xPA1-DC xenografts was also evaluated. Pharmacokinetics and radiation dosimetry were examined using PET images acquired after the ip administration of 64Cu-NCAB001 into cynomolgus monkeys with pharmacologic safety monitoring. Results: Radio-chromatography, cell-binding assays, and biodistribution of 64Cu-NCAB001 in mice were identical to those of our previous data with clinically available cetuximab. Small tumor lesions in the pancreas (≥3 mm) of mice could be identified by 64Cu-NCAB001 ipPET. The ip administration of 64Cu-NCAB001 into monkeys was safely conducted using ultrasound imaging. PET images in monkeys showed that ip-administered 64Cu-NCAB001 was distributed throughout the intraperitoneal cavity for up to 6 h and cleared thereafter. Most of the radioactivity was distributed in the liver and the large intestine. The radioactivity around the pancreas became negligible 24 h after administration. The estimated human effective dose was 0.0174 mSv/MBq. Conclusion: Our data support the initiation of clinical trials of 64Cu-NCAB001 ipPET to transfer this promising tool for the early diagnosis of pancreatic cancers.
Two negative regulators of biofilm development exhibit functional divergence in conferring virulence potential toCandida albicans (2018)

Candida albicans, a human pathogen, carries an expanded family of Zn(II)2Cys6 transcription factors. A CTG clade-specific protein Zcf32 and its closely related protein Upc2, a well-conserved transcription factor across the various fungal species, belong to this family of proteins. Unlike Upc2, Zcf32 is poorly studied in C. albicans. Here, we examined roles played by these two related transcription factors in biofilm development and virulence of C. albicans. Our data show that the null mutants of each of Zcf32 or Upc2 form better biofilms than the wild-type suggesting that both of them negatively regulate the biofilm development. While acting as negative regulators of biofilm formation, these two transcription factors target a different set of biofilm genes. A mouse model of candidiasis reveals that zcf32/zcf32 was hypervirulent, while upc2/upc2 shows compromised virulence compared to the wild-type. Notably, the absence of Zcf32 enhances detrimental inflammation brought about by TNFα, IFNβ and IFNγ. upc2/upc2 failed to generate a similar feedback, instead demonstrated an elevated anti-inflammatory (IL4 and IL10) host response. Taking together, we show how a recently evolved transcription factor Zcf32 retained functional resemblance with a more ubiquitous member Upc2 but also functionally diverged from the latter in the regulation of biofilm development and virulence of the pathogen.
Trends and future of fiber Bragg grating sensing technologies: tailored draw tower gratings (DTGs) (2014)

Today fiber Bragg gratings are commonly used in sensing technology as well as in telecommunications. Numerous requirements must be satisfied for their application as a sensor such as the number of sensors per system, the measurement resolution and repeatability, the sensor reusability as well as the sensor costs. In addition current challenges need to be met in the near future for sensing fibers to keep and extend their marketability such as the suitability for sterilization, hydrogen darkening or the separation of strain and temperature (or pressure and temperature). In this contribution we will give an outlook about trends and future of the fiber Bragg gratings in sensing technologies. Specifically, we will discuss how the use of draw tower grating technology enables the production of tailored Bragg grating sensing fibers, and we will present a method of separating strain and temperature by the use of a single Bragg grating only, avoiding the need for additional sensors to realize the commonly applied temperature compensation.
Bax, Bcl‐2, Fas and Fas‐L antigen expression in human seminoma: Correlation with the apoptotic index (2002)

Apoptosis plays a crucial role in the regulation of spermatogenesis in male germ cells and is, at least in part, modulated by Bcl-2, Bax, and the Fas pathway. Seminomas have a favourable outcome and respond to radio-/chemotherapy with an increased rate of apoptosis. The expression of Bax, Bcl-2, Fas and Fas-ligand (Fas-L) in human seminoma was evaluated and correlated with the apoptotic index. Twenty-nine classical seminomas were examined by immunohistochemistry and Western blotting using antibodies against Bax, Bcl-2, Fas and Fas-L. Apoptosis was detected by in-situ end-labeling of fragmented DNA and the apoptotic index (AI) was determined. Expression of Fas was found in 26 (89.7%) of Fas-L in 24 seminomas (82.2%); none of the tumours expressed Bcl-2. No correlation between the AI and Fas, Fas-L or Bcl-2 expression was found. Bax was demonstrated in 20/29 tumours (69%). Bax-positive tumours showed an increased AI of 4.75 +/- 2.38% in contrast to 2.60 +/- 1.23% of the Bax-negative tumours (P = 0.002). The number of Bax-positive tumour cells and apoptotic cells revealed a significant correlation using chi2-test (P = 0.04) and linear regression (r = 0.54, P = 0.001). Therefore, Bax seems to play a determinant role in the modulation of apoptosis in human seminoma that may be linked to a favourable outcome.
Synthesis of Real-Time Implementations from Component-Based Software Models (2006)

Component-based software development is an effective technique for tackling the increasing complexity of large-scale embedded software systems. After building a logical software model, the designer must make design decisions, including choosing a multi-threading strategy and assigning priorities to threads, to ensure that the final implementation on the target execution platform satisfies non-functional requirements. Code generators for software design tools produce functional code, but typically ignore concurrency and timing issues. In this paper, we describe techniques for real-time scheduling and design-space exploration and optimization, with the goal of helping the designer synthesize efficient real-time implementations from component-based software models. Experimental evaluation shows that our techniques yield high-quality implementations with reasonable running time of the optimization algorithm.
No midterm advantages in the middle term using small intestinal submucosa and human amniotic membrane in Achilles tendon transverse tenotomy (2016)

SIS showed superior biomechanical properties and neovascularization over HAM in treatment of Achilles tendon injury in the early stage of healing.
Automated volumetric retinal imaging with complete visualization of Henle’s fiber layer using robotically aligned optical coherence tomography (2022)

Optical coherence tomography (OCT) allows for in vivo imaging of the individual layers of the retina, but conventional methods do not differentiate the outer nuclear layer (ONL) from Henle’s fiber layer (HFL). We have developed a robotically aligned OCT (RAOCT) system capable of automatically acquiring volumes at multiple pupil entry positions to reconstruct a retinal volume that distinguishes the HFL from the ONL. We utilized the RAOCT system to acquire such volumes from consented subjects, and used mosaicking to combine them into complete retinal volumes that show enhanced contrast in the HFL on all sides of the fovea.
Metallocene antitumor agents. Unusual Mo(.eta.5-C5H5)2Cl2 nucleotide/nucleobase aqueous coordination chemistry (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetallocene antitumor agents. Unusual Mo(.eta.5-C5H5)2Cl2 nucleotide/nucleobase aqueous coordination chemistryLouis Y. Kuo, Mercouri G. Kanatzidis, and Tobin J. MarksCite this: J. Am. Chem. Soc. 1987, 109, 23, 7207–7209Publication Date (Print):November 1, 1987Publication History Published online1 May 2002Published inissue 1 November 1987https://pubs.acs.org/doi/10.1021/ja00257a061https://doi.org/10.1021/ja00257a061research-articleACS PublicationsRequest reuse permissionsArticle Views160Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Dispersity under Scrutiny: Phase Behavior Differences between Disperse and Discrete Low Molecular Weight Block Co-Oligomers (2017)

An experimental study is presented in which we compare the bulk phase behavior of discrete and (partially) disperse diblock co-oligomers (BCOs) with high χ-low <i>N</i>. To this end, oligomers of dimethylsiloxane (<i>o</i>DMS) and lactic acid (<i>o</i>LA) were synthesized, each having either a discrete number of repeat units or a variable block length. Ligation of the blocks resulted in <i>o</i>DMS-<i>o</i>LA BCOs with dispersities ranging from <1.00001 to 1.09, as revealed by mass spectroscopy and size exclusion chromatography. The phase behavior of all BCOs was investigated by differential scanning calorimetry and small-angle X-ray scattering. Compared to the well-organized lamellae formed by discrete <i>o</i>DMS-<i>o</i>LA, we observe that an increase in the dispersity of these BCOs results in (1) an increase of the <i>stability</i> of the microphase-segregated state, (2) a decrease of the overall <i>degree of ordering</i>, and (3) an increase of the <i>domain spacing</i>.
Using Climatological, Geographical, and Taxonomic Information to Identify Sources of Mature‐Plant Salt Tolerance in Alfalfa (1994)

Performance under salinity stress has been improved in elite populations of alfalfa ( Medicago sativa L. sensu lato ) by mass selection. Use of unimproved germplasm may permit additional gains in salt tolerance or access to unique tolerance mechanisms. Resources would be used more efficiently if germplasm with specific traits could be identified from large collections using taxonomical, climatological, or geographical data. Our objective was to determine whether such information could be used to identify M. sativa accessions in the U.S. plant introduction (PI) collection likely to have improved response to salinity. We evaluated forage yield for three harvests in 630 Pis under saline (80 m M NaCI) and nonsaline irrigation in greenhouse trials. Passport data were used to classify climate (Trewartha's system) at the collection site. No significant differences were found in mean salt tolerance (forage yield with saline irrigation/nonsaline irrigation) among the subspecies of M. sativa sampled extensively ( falcata, caerulea, varia , and sativa ). Accessions considered either tolerant or with high saline yield (high forage yield with saline irrigation; highest 15.1% of accessions for these traits) were present in all subspecies. Mean salt tolerance and saline yield for accessions, and the proportion of accessions considered tolerant or with high saline yield did not differ between accessions from six basic climate groups (Tropical, Arid, Subtropical, Temperate, Boreal, Highland). An increased proportion of tolerant accessions was found from arid environments where alfalfa is usually grown without irrigation. The effects of agronomic practices seems to represent a major limitation to use of climatological data in identifying germplasm with improved performance under salinity stress.
AES-GCM-SIV: Nonce Misuse-Resistant Authenticated Encryption (2019)

This memo specifies two authenticated encryption algorithms that are
nonce misuse-resistant - that is that they do not fail
catastrophically if a nonce is repeated.
Continuous Optical Fiber Gratings for Distributed Sensing (2022)

Recent progress in the design, fabrication and analysis of very long continuous Bragg gratings in single and multicore fibers for distributed acoustic and shape sensing is presented, with applications ranging from railway monitoring to surgery.