gebhart/patrepeval huggingface dataset:
Ergoline synthons: Synthesis of 3,4-dihydro-6-methoxybenz[cd]indol-5(1H)-one (6-methoxy-Uhle's ketone) and 3,4-dihydrobenz[cd]indol-5(1H)-one (Uhle's ketone) via a novel decarboxylation of indole-2-carboxylates (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTErgoline synthons: Synthesis of 3,4-dihydro-6-methoxybenz[cd]indol-5(1H)-one (6-methoxy-Uhle's ketone) and 3,4-dihydrobenz[cd]indol-5(1H)-one (Uhle's ketone) via a novel decarboxylation of indole-2-carboxylatesMichael D. Meyer and Lawrence I. KruseCite this: J. Org. Chem. 1984, 49, 17, 3195–3199Publication Date (Print):August 1, 1984Publication History Published online1 May 2002Published inissue 1 August 1984https://pubs.acs.org/doi/10.1021/jo00191a028https://doi.org/10.1021/jo00191a028research-articleACS PublicationsRequest reuse permissionsArticle Views1112Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Composite Correlated Molecular Orbital Theory Calculations of Ring Strain for Use in Predicting Polymerization Reactions (2022)

Strained ring systems play an important role in synthesis and can be characterized by the ring strain energy (RSE). The RSE of 3, 4, 5, and 6 membered saturated and unsaturated ring systems containing N, O, P, and S heteroatoms and H, F, SiMe<sub>3</sub> , and SO<sub>2</sub> Me substituents were calculated at the G3(MP2) composite correlated molecular orbital theory level using up to 5 models to predict the RSE. Generally, the RSE decreased as ring size increased with a substantial decrease from 4 to 5 membered rings. Replacement of a ring CH<sub>2</sub> with P or S reduced the RSE, consistent with less angle strain. The RSE for unsaturated systems were generally greater than for saturated systems due to increased angle strain. No general trends were found with respect to substituent effects. The RSE values suggest that 3-pyrroline and 2-pyrroline and their derivatives may be able to support ring opening metathesis polymerization and warrant further study.
Sequence‐Specific DNA Binding by Noncovalent Peptide–Tripyrrole Conjugates (2006)

To join the groove: Equipping basic-region bZIP peptides with a noncovalent heterodimerizing unit allows their major-groove DNA-binding capability to be triggered upon addition of appropriate external ligands that bind into adjacent minor-groove sites. The resulting noncovalent hybrids bind relatively long DNA sites with good affinity and very high specificity. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z603115_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Demonstration of Bloch Surface Waves in crystals with LiNbO3 thin films (2016)

A novel one dimensional photonic crystal (1DPHC) sustaining Bloch surface waves (BSWs) with a single crystal thin film lithium niobate (TFLN) as a part of a multilayer is theoretically and experimentally investigated. Properties of the dielectric multilayer platform with optical anisotropy introduced by X-cut TFLN are studied.
Rapid stimulation of rhodamine 123 efflux from multidrug-resistant KB cells by progesterone (1993)

Rhodamine 123 is a mitochondrial dye that is retained for prolonged periods by carcinoma cells. While investigating causes of retention of this dye, we found that 10 microM progesterone caused a rapid stimulation of efflux of rhodamine 123 within 15 min from KB V20C cells, which overexpress the multidrug resistance pump. Progesterone did not stimulate efflux from KB cells that do not overexpress the pump, and verapamil blocked rhodamine 123 efflux in the presence or absence of progesterone, indicating that rhodamine 123 is removed from KB V20C cells by the multidrug resistance pump. Progesterone, however, is unlikely to stimulate rhodamine 123 efflux by simply increasing pump activity for two reasons: (1) progesterone inhibited the efflux of daunomycin from KB V20C cells, so it did not stimulate efflux of all drugs, and (2) progesterone inhibited efflux of rhodamine 123 from L1210/VMDRC cells and had little effect on Adr MCF7 cells; both overexpress the multidrug resistance pump. In the experiments with KB V20C cells, progesterone was the most active steroid tested. At 10 microM, progesterone caused a 70-fold stimulation, desoxycorticosterone, testosterone, promegestone and estradiol about 20-fold, and others had little or no effect. Progesterone may act by a non-genomic mechanism to decrease intracellular binding of rhodamine 123, making the dye accessible to the multidrug resistance pump.
Salt-responsive lytic polysaccharide monooxygenases from the mangrove fungus Pestalotiopsis sp. NCi6 (2016)

Two new LPMOs from the mangrove fungus Pestalotiopsis sp. NCi6 were found to be fully reactive against cellulose. The combined hydrolytic activities of these salt-responsive LPMOs could therefore facilitate the saccharification process using sea water as a reaction medium for large-scale biorefineries.
Gadopentetate Dimeglumine as an Intradiscal Contrast Agent (2002)

The high interscan and interobserver correlation rates obtained for magnetic resonance discography using gadolinium, as compared with the standard computed tomographic discography technique, indicate that magnetic resonance discography may be an acceptable substitute for the imaging of disc pathology. Magnetic resonance discography with gadolinium can be recommended for patients allergic to iodinated contrast agents and for patients who wish to limit their radiation exposure.
Optimal server assignment in multi-server parallel queueing systems with random connectivities and random service failures (2012)

The problem of assignment of K identical servers to a set of N symmetric parallel queues is investigated in this paper. The parallel queueing system is considered to be time slotted and the connectivity of each queue to each server is varying randomly over time and following Bernoulli distribution with a given parameter. Each server is capable of serving at most one packet per time slot (if it is connected and assigned to a queue). At any time slot, each server can serve at most one queue and each queue can be served by at most one server. We assume that the service of a scheduled packet by a connected server fails randomly with a certain probability. The packet arrival processes to the queues are assumed to be i.i.d. and follow Bernoulli distribution with a fixed parameter. For such a symmetric system, i.e., with the same arrival, connectivity and service failure parameters for all the queues, we show that Maximum Weighted Matching (MWM) server assignment policy is delay optimal. More specifically, using stochastic ordering and dynamic coupling techniques we prove that MWM minimizes, in stochastic ordering sense, a broad range of stochastic cost functions of the queue lengths including total queue occupancy (or equivalently average queueing delay).
Penetration of Glucose Oxidase into Organized Phospholipid Monolayers Spread at the Solution/Air Interface (1997)

Adsorption of glucose oxidase (GOx) at the solution/air interface in the presence and in the absence of spread monolayers of dibehenoylphosphatidylcholine (DBPC) has been monitored by surface tension and surface potential measurements. At the monolayer-free interface and at the solution concentration levels of the enzyme higher than 4 μg/mL, this adsorption was found to be concentration and time dependent. Below this threshold concentration value, no decrease in the surface tension could be observed. Conversely, in the presence of dibehenoylphosphatidylcholine (DBPC) monolayers, increments in surface pressure were recorded even at GOx solution concentrations at which no diminution of the surface tension at the monolayer-free interface was observed. These increments in surface pressure decreased with the increase in the initial surface pressure of DBPC monolayers independently of the mode of compression of monolayers (addition of DBPC aliquots at constant area or dynamic compression). The increase in surface pressure following the injection of GOx molecules beneath a DBPC monolayer has been attributed to the occurrence of a hydrophobic interaction between hydrocarbon chains of the phospholipid and the enzyme. The differences in the magnitude and in the rate of the enzyme penetration into spread DBPC monolayers are discussed and modeled with respect to the mode of compression of monolayers.
Dual Fuel Injection (DI + PFI) for Knock and EGR Dilution Limit Extension in a Boosted SI Engine (2018)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Combined direct and port fuel injection (i.e., dual injection) in spark ignition engines is of increasing interest due to the advantages for fuel flexibility and the individual merits of each system for improving engine performance and reducing engine-out emissions. Greater understanding of the impact of dual injection will enable deriving the maximum benefit from the two injection systems. This study investigates the effects of dual injection on combustion, especially knock propensity and tolerance to exhaust gas recirculation (EGR) dilution at different levels of EGR. A baseline for comparison with dual injection results was made using direct injection fueling only. A splash blended E20 fuel was used for the direct injection only tests. For the dual injection tests, gasoline, representing 80% by volume of the total fuel, was injected using the direct injector, and ethanol, representing 20% by volume of the total fuel, was injected using the port fuel injector. EGR mass fraction was varied from 0% to 21%, under boosted intake air pressure of 1.25 bar for both injection strategies. The results showed dual injection was beneficial to shorten the burn duration and improve combustion stability. Dual injection was more sensitive to knock than direct injection primarily due to increased unburned gas temperature. The overall thermal efficiency for the two injection types was comparable. The particulate matter emissions from dual injection showed slightly lower values, and the gaseous emissions showed lower total hydrocarbons and similar nitrogen oxides compared with only using direct injection of E20.&lt;/div&gt;&lt;/div&gt;
Phase Equilibria and Thermodynamic Properties in the V<I><SUB>n</SUB></I>O<SUB>2<I>n</I>&minus;1</SUB> System (1971)

The phase equilibria of the V2O3–VO2 system in connection with the oxygen activity were established in the temperature range from 600° to 1200°C. A quenching method was applied to the experiments from 1000° to 1200°C under controlled oxygen atmosphere with the use of a CO2–H2 gas mixture. For the temperature range from 600° to 1000°C, a solid electrolyte cell of the type; Pt/adjacent two-phase mixture (VnO2n−1+Vn+1O2(n+1)−1)/(ZrO2)0.85(CaO)0.15/O2 (air reference electrode)/Pt, was utilized to measure the oxygen activity. The standard free energy changes of the reactions (n+1)VnO2n−1+1⁄2O2\ ightleftarrowsnVn+1O2(n+1)−1 were calculated from the electromotive force developed by the cell.
Does Asymptotic Transverse Macrodispersion Exist In Steady Darcy Flow (2019)

International audience
0477 Comparison of a Non-Contact Sleep Monitoring Device with Wrist Actigraphy in a Sample of Individuals with Chronic Insomnia (2022)

Abstract Introduction Non-contact devices (NCDs) have been developed to measure sleep longitudinally and unobtrusively in the naturalistic home setting. We compared longitudinal measurements from a wrist actigraph (Actiwatch-2, Philips Respironics) and from a NCD (SleepScore Max, SleepScore Labs) in a sample of adults with insomnia Methods N=71 adults (ages 39.0±13.0y; 50 women) who met ICSD-3 criteria for chronic insomnia and were otherwise healthy participated in an at-home sleep monitoring study. Participants continuously wore the actigraph for one week, then used the NCD to record only nightly sleep periods for the next 8 weeks. Week-by-week within-subject averages and standard deviations (SDs) over days were assessed for five major sleep parameters: total sleep time (TST), sleep onset latency (SOL), wake after sleep onset (WASO), time in bed (TIB), and sleep efficiency (SE). These sleep parameters were analyzed with mixed-effects ANOVA comparing week one (actigraphy) to the next 8 weeks (NCD), and correlations between the first week (actigraphy) and second week (NCD) were calculated. Results Significant differences for actigraphy versus NCD were found for the weekly averages of SOL and WASO (F&amp;gt;25.8, p&amp;lt;0.001). The NCD measured longer average SOL (M±SEM=25.0±1.5min) than actigraphy (12.6±2.0min) and less average WASO (40.5±2.7min) than actigraphy (51.1±3.2min). Further, significant differences were found for the weekly within-subject SDs of TST and WASO (F&amp;gt;7.52, p&amp;lt;0.01). The NCD measured greater SD for TST (71.6±2.8min) than actigraphy (60.0±4.7min) and greater SD for WASO (25.0±1.4min) than actigraphy (19.2±2.2min). Actigraphy and NCD weekly averages were positively correlated for TST, WASO, TIB, and SE (p&amp;lt;0.001), but not SOL (r=0.03, p=0.80). Similarly, weekly within-subject SDs were positively correlated for TST, WASO, TIB, and SE (p≤0.05), but not SOL (r=–0.03, p=0.81). Conclusion Actigraphy and NCD were not used simultaneously, precluding a direct comparison between these measurement modalities. Nonetheless, in this ecologically valid context, significant differences were only found for the weekly averages of SOL and WASO and for the weekly within-subject variability of SOL and TST, with significant correlations between the devices for all variables except SOL. Although actigraphy tends to underestimate SOL, NCD validation against polysomnography in chronic insomnia is warranted. Support (If Any) NIH grant KL2TR002317; research devices provided by SleepScore Labs.
Bioprocessing Separations Consortium Three-Year Overview: Technical Advances, Process Economics Influence, and State of the Science (2020)

The Bioprocessing Separations Consortium solves separations challenges that are unique to bioprocessing. To do this, the Consortium uses two methods: applying existing technologies to new challenges and developing new technologies that may address these unique challenges better than today’s commercial technologies. In its research and development, the Consortium leverages its three core capabilities: materials development and evaluation, process development, and analysis and computation. In its first three years, from 2016 to 2019, the Consortium addressed four critical challenges in biochemical and thermochemical processing. First, the Consortium targeted the fractionation of lignin to enable valorization of this portion of biomass that offers diverse, complex, and valuable building blocks and products. Second, Consortium researchers developed technologies to enable process intensification, which can reduce equipment needs, energy consumption, and waste generation, thereby cutting bioprocessing capital costs and rendering processes more efficient. Third, the Consortium sought to recover carbon from dilute aqueous streams that are common to bioprocessing; recovering dilute carbon can improve process efficiency and economics. Finally, Consortium researchers designed and developed new materials and catalysts to reduce targeted foulants and poisons in bioprocessing streams that can limit the lifetime of downstream catalysts or fermenting microorganisms. Table 1 lists the technologies that were examined and places them in the context of the Consortium’s capabilities, types of bioprocesses, and critical challenges in bioprocessing separations. Overall, across these projects, we have developed separations technologies for 10 bioprocesses, addressed 9 target compounds in bioprocessing, developed 10 materials, and evaluated 4 processes for cost and sustainability.
Active micro-mixers using surface acoustic waves on Y-cut 128° LiNbO3 (2006)

This study presents an active method for micro-mixers using surface acoustic waves (SAW) to rapidly mix co-fluent fluids. Mixing is challenging work in microfluidic systems due to their low-Reynolds-number flow conditions. SAW devices were fabricated on 128° Y-cut lithium niobate (LiNbO3). The micro-mixers are these piezoelectric actuators integrated with polydimethylsiloxane microchannels. The effects of the applied voltages on interdigitated transducers (IDTs) and two layouts, parallel- and transversal-type, of micro-mixers on the mixing performance were experimentally explored. The experimental results revealed that the parallel-type mixer achieved a higher mixing effect. Meanwhile, a higher applied voltage on the IDTs led to a significant improvement in the mixing performance of the active micro-mixer. Typical temperature effects associated with the applied voltages on the IDTs were also investigated. Finally, a digestion reaction between a protein (hemoglobin) and an enzyme (trypsin) was performed to verify the capability of the micro-mixers. The protein–enzyme mixture was qualitatively analyzed using mass spectrometry. Using these SAW-based mixers, the amount of digested peptides increased. Additionally, the protein–enzyme mixture was also quantitatively analyzed using high-performance liquid chromatography. Experimental data showed that the amount of digested peptides increased 21.1% using the active mixer. Therefore, the developed micro-mixers can be applied in microfluidic systems for improving mixing efficiency and thus enhancing the bio-reaction.
Conclusion (2017)

Abstract The European state contains too many contradictions to take its persistence for granted. The challenges facing the restructured European state in 2016 are among the most basic associated with the minimal Weberian features: maintaining a monopoly on the legitimate use of force, protecting individual rights against violence and aggression, enforcing the rule of law, and defending state territorial boundaries. Almost all the chapters in this volume show the dilution of these Weberian tasks, as the state’s internal and external relations and institutional structures reconfigure under the weight of a systematic diffusion of neoliberal market mechanisms; and the rapid institutionalization of the European Union and its agencies, policies, regulations, and laws as defining components of member states. Despite crisis and challenge the European state’s resilience—both nationally and at the EU level—stand out. This chapter identifies the state-making and state-destroying mechanisms effecting the major reconfiguration of European states.
Task Frames (2000)

Forty years ago Dijkstra introduced the current conventional execution of routines. It places activation frames onto a stack. Each frame is the internal state of an executing routine. The resulting application execution is not easily helped by an external system. This presentation proposes an alternative execution of routines. It places task frames onto the stack. A task frame is the call of a routine to be executed. The feasibility of the alternative execution is demonstrated by a crude implementation. As described elsewhere, an application which executes in terms of tasks can be provided by an external system with a transparent reliable, distributed, heterogeneous, adaptive, dynamic, real-time, parallel, secure or other execution. By extending the crude implementation, this presentation outlines a simple transparent parallel execution.
Online Undergraduate Laboratories in Electrical Engineering (2019)

This innovative practice paper describes the development of online undergraduate laboratories in electrical engineering as a work in progress. Our goal is to create electrical engineering labs for the online program that are equivalent to on-campus labs. Equivalence implies that labs support the same cognitive and affective learning outcomes for both on-campus and online students. We addressed this challenge by implementing labs that fall into three specific categories: (1) labs which have a hands-on component that was realized in the online program using student-owned hardware, (2) labs which involve a simulation experience or are supported by virtual reality environments and (3) virtual laboratories that allow remote access to high-value equipment using freely available web conferencing tools. Assessment data based on Accreditation Board for Engineering and Technology (ABET) student performance criteria and student course feedback confirm that the laboratories are effective and well-received by students.
<title>Modeling human bodies from video sequences</title> (1998)

In this paper, we show that, given video sequences of a moving person acquired with a multi-camera system, we can track joint locations during the movement and recover shape information. We outline techniques for fitting a simplified model to the noisy 3-D data extracted from the images and a new tracking process based on least squares matching is presented. The recovered shape and motion parameters can be used to either reconstruct the original sequence or to allow other animation models to mimic the subject's actions. Our ultimate goal is to automate the process of building complete and realistic animation models of humans, given a set of video sequences.