gebhart/patrepeval huggingface dataset:
Intracavernous delivery of clonal mesenchymal stem cells rescues erectile function in the streptozotocin‐induced diabetic mouse (2015)

The major hurdle for the clinical application of stem cell therapy is the heterogeneous nature of the isolated cells, which may cause different treatment outcomes. The aim of this study was to examine the effectiveness of mouse clonal bone marrow-derived stem cells (BMSCs) obtained from a single colony by using subfractionation culturing method for erectile function in diabetic animals. Twelve-week-old C57BL/6J mice were divided into four groups: controls, diabetic mice, and diabetic mice treated with a single intracavernous injection of PBS (20 μL) or clonal BMSCs (3 × 10(5) cells/20 μL). Clonal BMSCs were isolated from 5-week-old C3H mice. Two weeks after treatment, erectile function was measured by electrical stimulation of the cavernous nerve. The penis was stained with antibodies to PECAM-1, smooth muscle α-actin, neuronal nitric oxide synthase (nNOS), neurofilament, and phosphorylated endothelial NOS (phospho-eNOS). We also performed Western blot for phospho-eNOS, and eNOS in the corpus cavernosum tissue. Local delivery of clonal BMSCs significantly restored cavernous endothelial and smooth muscle cell contents, and penile nNOS and neurofilament contents, and induced eNOS phosphorylation (Ser1177) in diabetic mice. Intracavernous injection of clonal BMSCs induced significant recovery of erectile function, which reached 80-90% of the control values. Clonal BMSCs successfully restored erectile function through dual angiogenic and neurotrophic effects in diabetic mice. The homogenous nature of clonal mesenchymal stem cells may allow their clinical applications and open a new avenue through which to treat diabetic erectile dysfunction.
Chemical and Structural Parameter Connecting Cavity Architecture, Confined Hydrocarbon Pool Species, and MTO Product Selectivity in Small-Pore Cage-Based Zeolites (2019)

The catalysts used in the methanol-to-olefins (MTO) reaction are considered dual systems comprising an inorganic zeolite framework and organic compounds hosted inside that act as cocatalysts. The influence of zeolite cavity architecture on the preferential stabilization of cationic intermediates involved in the paring and side-chain routes of the hydrocarbon pool mechanism is analyzed by means of density functional theory (DFT) calculations, catalyst testing, and 13C NMR spectroscopy for some small-pore cage-based zeolites. A correlation between the degree of methylation of the entrapped methylbenzenium (MB+) cations and the selectivity to ethene and propene is found experimentally and explained in terms of the electronic distribution of the first intermediate of the paring route. A deep understanding of the reaction mechanism and of the specific host–guest interactions taking place inside zeolite catalysts allows establishing a quantitative parameter that is indicative for the contribution of the paring route and therefore the C3=/C2= ratio in the MTO reaction.
6G Architectural Trends and Enablers (2021)

By 2030, the next generation mobile network (6G) is expected to be ready. Currently, as work on 6G is being ramped up, prospective technical components are being explored with objective to fulfil challenges and requirements expected for 6G. In this paper we address the important task of reevaluating and evolving the network architecture, to ensure that performance, e.g., data rates, coverage, energy efficiency, will support use cases, both current and future, while minimizing total cost of ownership (TCO). This task includes aspects of cloudification, where shared generic hardware replaces dedicated hardware to improve flexibility and reduce TCO, jointly with cloud-optimized network architecture, as well as more flexible deployments expected for 6G, for instance, macro base stations, mesh networks, satellites, private networks, and connectivity using sub-THz frequencies, which are expected for 6G. Given this range of deployments, the network will need novel procedures for mobility to ensure reliable and resilient connectivity with unprecedented performance.
All-fiber broadband frequency comb source at 2050 nm center wavelength (2013)

In the last decade, laser development based on Tm and Ho doped materials in the mid-IR has made a significant progress, especially in fiber technology [1-2]. Current work focusses on Tm doped fiber broadband amplifiers at the central wavelength toward 1.95 μm with high average power and pulse duration of 141 fs [3]. Whereas purely Tm doped fibers are well suited for a center wavelength in the 1.9–2 μm range, the co-doping with Ho ions shifts the gain region to 2–2.15 μm in the water transparency window. Up to our knowledge, no broadband fiber based amplifier has been demonstrated using the advantage of Tm/Ho co-doping.
EM-Cube (1997)

EM-Cube is a VLSI architecture for low-cost, high quality volume rendering at full video frame rates. Derived from the Cube4 architecture developed at SUNY at Stony Brook, EM-Cube computes sample points and gradients on-the-fly to project 3-dimensional volume dnta onto 2-dimensional images with realistic lighting and shading. A modest rendering system based on EM-Cube consists of a PC1 card with four rendering chips (ASICs), four 64Mbit SDRAMs to hold the volume data, and four SRAMs to capture the rendered image. The performance target for this configuration is to render images from a 25G3 x 16 bit data set at 30 fmmes/sec. The EM-Cube architecture can be scaled to larger volume data-sets and/or higher frame rates by adding additional ASKS, SDRAMs, and SRAMs. This paper addresses three major challenges encountered developing EM-Cube into a pm&al product: exploiting the bandwidth inherent in the SDRAMs containing the volume data, keeping the pin-count between adjacent ASICs at a tractable level, and reducing the on-chip stomge required to hold the intermediate results of rendering.
Importance of biexcitonic scattering in exciton dephasing in quantum dots (2003)

Summary form only given. The mechanism of exciton dephasing was clarified in zero-dimensional(0-D) InGaAs quantum dots by high-energy resolution single dot spectroscopy. We measured the exciton dephasing time from homogenous linewidth of excited levels of an exciton in an isolated quantum dot. Although the exciton acoustic phonon scattering has been believed to be the origin of the dephasing so far, we found that the biexcitonic scattering plays an very important role in the dephasing. This is a distinct feature of the 0-D quantum dot structure which has never been observed in 3-D, 2-D and 1-D structures.
Corrosion-Resistant Coatings on Spent Nuclear Fuel Canisters to Mitigate and Repair Potential Stress Corrosion Cracking (FY22 Status) (2022)

This report summarizes the activities performed by Sandia National Laboratories in FY22 to identify and test coating materials for the prevention, mitigation, and/or repair of potential chloride-induced stress corrosion cracking in spent nuclear fuel dry storage canisters. This work continues efforts by Sandia National Laboratories that are summarized in previous reports in FY20 and FY21 on the same topic. The previous work detailed the specific coating properties desired for application and implementation to spent nuclear fuel canisters (FY20) and identified several potential coatings for evaluation (FY21). In FY22, Sandia National Laboratories, in collaboration with four industry partners through a Memorandum of Understanding, started evaluating the physical, mechanical, and corrosion-resistance properties of 6 different coating systems (11 total coating variants) to develop a baseline understanding of the viability of each coating type for use to prevent, mitigate, and/or repair potential stress corrosion on cracking on spent nuclear fuel canisters. This collaborative R&D program leverages the analytical and laboratory capabilities at Sandia National Laboratories and the material design and synthesis capabilities of the industry collaborators. The coating systems include organic (polyetherketoneketone, modified polyimide/polyurea, modified phenolic resin), organic/inorganic ceramic hybrids (silane-based polyurethane hybrid and a quasi-ceramic sol-gel polyurethane hybrid), and hybrid systems in conjuncture with a Zn-rich primer. These coatings were applied to stainless steel coupons (the same coupons were supplied to all vendors by SNL for direct comparison) and have undergone several physical, mechanical, and electrochemical tests. The results and implications of these tests are summarized in this report. These analyses will be used to identify the most effective coatings for potential use on spent nuclear fuel dry storage canisters, and also to identify specific needs for further optimization of coating technologies for their application on spent nuclear fuel canisters. In FY22, Sandia National Laboratories performed baseline testing and atmospheric exposure tests of the coating samples supplied by the vendors in accordance with the scope of work defined in the Memorandum of Understanding. In FY23, Sandia National Laboratories will continue evaluating coating performance with a focus on thermal and radiolytic stability.
COMBINED TRACTIONAL RHEGMATOGENOUS RETINAL DETACHMENT IN FAMILIAL EXUDATIVE VITREORETINOPATHY ASSOCIATED WITH POSTERIOR RETINAL HOLES: Surgical Therapy (1998)

From the*Department of Ophthalmology, Kyoto Prefectural University of Medicine, and †Department of Ophthalmology, Osaka University Medical School, Osaka, Japan. This study was supported in part by the Japanese Ministry of Education. Culture and Science (research grants 06454500 and 06771529). the Kyoto Foundation for the Promotion of Medical Science, and the intramural research fund of Kyoto Prefectural University of Medicine. Reprint requests: Tsunehiko Ikeda, MD, Department of Ophthalmology. Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji Kamigyo-ku, Kyoto 602-0841, Japan.
Premixed calcium silicate cement for endodontic applications: injectability, setting time and radiopacity. (2014)

Calcium silicate-based materials (also called MTA) are increasingly being used in endodontic applications. However, the handling properties of MTA are not optimal when it comes to injectability and cohesion. Premixing the cements using glycerol avoids these issues. However, there is a lack of data on the effect of common cement variables on important properties of premixed cements for endodontic applications. In this study, the effects of liquid-to-powder ratio, amount of radiopacifier and amount of calcium sulfate (added to control the setting time) were screened using a statistical model. In the second part of the study, the liquid-to-powder ratio was optimized for cements containing three different amounts of radiopacifier. Finally, the effect of using glycerol rather than water was evaluated in terms of radiopacity. The setting time was found to increase with the amount of radiopacifier when the liquid-to-powder ratio was fixed. This was likely due to the higher density of the radiopacifier in comparison to the calcium silicate, which gave a higher liquid-to-powder ratio in terms of volume. Using glycerol rather than water to mix the cements led to a decrease in radiopacity of the cement. In conclusion, we were able to produce premixed calcium silicate cements with acceptable properties for use in endodontic applications.
Counterfactual reasoning and learning systems: the example of computational advertising (2013)

This work shows how to leverage causal inference to understand the behavior of complex learning systems interacting with their environment and predict the consequences of changes to the sys-tem. Such predictions allow both humans and algorithms to select the changes that would have improved the system performance. This work is illustrated by experiments on the ad placement system associated with the Bing search engine.
Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma (2017)

Alterations in PIK3CA, the gene encoding the p110α subunit of phosphatidylinositol 3-kinase (PI3Kα), are frequent in head and neck squamous cell carcinomas. Inhibitors of PI3Kα show promising activity in various cancer types, but their use is curtailed by dose-limiting side effects such as hyperglycaemia. In the present study, we explore the efficacy, specificity and safety of the targeted delivery of BYL719, a PI3Kα inhibitor currently in clinical development in solid tumours. By encapsulating BYL719 into P-selectin-targeted nanoparticles, we achieve specific accumulation of BYL719 in the tumour milieu. This results in tumour growth inhibition and radiosensitization despite the use of a sevenfold lower dose of BYL719 compared with oral administration. Furthermore, the nanoparticles abrogate acute and chronic metabolic side effects normally observed after BYL719 treatment. These findings offer a novel strategy that could potentially enhance the efficacy of PI3Kα inhibitors while mitigating dose-limiting toxicity in patients with head and neck squamous cell carcinomas.
Relationship of Retinal Vascular Caliber with Retinal Nerve Fiber Layer Thickness: The Singapore Malay Eye Study (2009)

Narrower retinal vessel caliber was associated with reduced RNFL thickness in this Asian population.
Tumor pretargeting in mice using oxygen-dependent degradable streptavidin and radioiodinated biotin: A comparison between immunohistochemical analysis of hypoxia-inducible factor-1{alpha} and autoradiography (2010)

221 Objectives Hypoxia-inducible factor-1α (HIF-1α) is degraded in an oxygen-dependent manner under normoxic conditions, but it is stable under hypoxic conditions and plays an important role in the progression of malignant tumors. We had previously developed an oxygen-dependent degradable streptavidin (POS) and a radiolabeled biotin [(3-123I-iodobenzoyl)norbiotinamide; 123I-IBB], and successfully used them in pretargeted tumor imaging. In the present study, we evaluated the feasibility of this pretargeting system for HIF-1-active tumor imaging. Methods The mice carrying tumors with the HIF-1-dependent luciferase reporter gene were pretargeted with POS, and 24 h later, they were administered 125I-IBB. The correlation between 125I-IBB accumulation and luciferase bioluminescence was examined at 6 h after administration of 125I-IBB. The radioactivity in the tumors was analyzed using size-exclusion chromatography at the same time point. The intratumoral distribution of 125I-IBB was examined by autoradiography, and the same sections were then subjected to HIF-1α immunohistochemical analysis. Results The tumoral accumulation of 125I-IBB significantly correlated with HIF-1-dependent luciferase bioluminescence (R = 0.84, P Conclusions The accumulation of 125I-IBB in the tumors pretargeted with POS corresponded with the expression of HIF-1. Therefore, this pretargeting system will be useful for imaging of HIF-1-active tumors
Targeting insulin to the liver corrects defects in glucose metabolism caused by peripheral insulin delivery (2019)

Peripheral hyperinsulinemia resulting from subcutaneous insulin injection is associated with metabolic defects which include abnormal glucose metabolism. The first aim of this study was to quantify the impairments in liver and muscle glucose metabolism that occur when insulin is delivered via a peripheral vein compared to when it is given through its endogenous secretory route (the hepatic portal vein) in overnight fasted conscious dogs. The second aim was to determine if peripheral delivery of a hepato-preferential insulin analog could restore the physiologic response to insulin that occurs under meal feeding conditions. This study is the first to show that hepatic glucose uptake correlates with insulin's direct effects on the liver under hyperinsulinemic-hyperglycemic conditions. In addition, glucose uptake was equally divided between the liver and muscle when insulin was infused into the portal vein, but when it was delivered into a peripheral vein the percentage of glucose taken up by muscle was 4-times greater than that going to the liver, with liver glucose uptake being less than half of normal. These defects could not be corrected by adjusting the dose of peripheral insulin. On the other hand, hepatic and non-hepatic glucose metabolism could be fully normalized by a hepato-preferential insulin analog.
Data acquisition system for Harmonic Motion Microwave Doppler Imaging (2014)

Harmonic Motion Microwave Doppler Imaging (HMMDI) is a hybrid method proposed for breast tumor detection, which images the coupled dielectric and elastic properties of the tissue. In this paper, the performance of a data acquisition system for HMMDI method is evaluated on breast phantom materials. A breast fat phantom including fibro-glandular and tumor phantom regions is produced. The phantom is excited using a focused ultrasound probe and a microwave transmitter. The received microwave signal level is measured on three different points inside the phantom (fat, fibro-glandular, and tumor regions). The experimental results using the designed homodyne receiver proved the effectiveness of the proposed setup. In tumor phantom region, the signal level decreased about 3 dB compared to the signal level obtained from the fibro-glandular phantom area, whereas this signal was about 4 dB higher than the received signal from the fat phantom.
ZNF683 (Hobit) Marks a CD8+ T Cell Population Associated with Anti-Tumor Immunity Following Anti-PD-1 Therapy for Richter Syndrome (2022)

International audience
Optimal Positioning for Advanced Raim (2013)

We present a method to improve the integrity error bound in Advanced RAIM by optimizing the position solution and the integrity allocation simultaneously. Since the reduction in the error bound is achieved by degrading the position accuracy under nominal conditions, the method takes into account the accuracy constraint in the optimization. Advanced RAIM may have to consider a larger number of satellites and increased probabilities of fault, so this method is designed to accept a wide variety of threat models (in particular multiple faults). The search of the optimal coefficients is cast as a convex optimization problem with constraints. The solution is obtained iteratively, and the convexity of the problem guarantees a very fast convergence. The algorithm is evaluated by comparing its performance with algorithms where the position solution is not optimized, and showing how it could help achieve worldwide coverage of vertical guidance (LPV-200). Copyright © 2013 Institute of Navigation
Structural analysis of rectangular metallic silos (2006)

Recently Brazil has undergone agricultural growth that has forced several sectors to adjusttheir business structure to maintain competitiveness within the process of economic globalization. Inthis context, the poultry production has focused on new alternatives to increase productivity andreduce costs without affecting the quality of the final product. Among these alternatives, the use ofvertical silos due to their capacity and ease of accurate feed ingredient rationing have reduced theneed for large horizontal warehouses. The present research has focused on the stresses inrectangular, hopper bottom bins with a unique zigzag corrugation. The model bin was 2m x 1m witha hopper and the stresses obtained when loaded with pelleted soybean meal and compared totheories and standards DIN 1055, ISO 11697, EUROCODE 1 and AS 3774. The stresses wereestimated using Ravenet and Troitskys simplified methods and compared to the experimentalresults. Strain gauges and displacement transducers were used to obtain data on the stress within the bin walls. It was concluded that either Ravenet or Troitskys theory can be recommended for thedesign of rectangular silos since they provide a high level of accuracy compared with experimentalvalues.
Next-generation IGBT module structure for hybrid vehicle with high cooling performance and high temperature operation (2014)

We developed a new technology for the Fuji 4 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> generation power module for hybrid vehicle application. It achieved a 30-% volume reduction, and a 33-% weight reduction compared to the 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> generation. Requirement trends for the power module for hybrid vehicles are high energy-efficient, downsizing, lightweight and higher reliability. To achieve these requirements, IGBT module needs low thermal resistance and high operating temperature. We developed new technologies, 1) New cooling structure with high cooling performance. 2) The Tjmax.=175°C continuous operation with automotive required quality.
Age-dependent food utilisation of Acheta domesticus (Orthoptera: Gryllidae) in small groups at two temperatures (2018)

Insects hold potential as a sustainable source of animal protein. In recent years a new and rapidly growing industry of insect-based foods has emerged. The house cricket, Acheta domesticus (L.) (Orthoptera: Gryllidae), is one of the most important insect species being produced commercially in the USA for feed and food. However, the price of cricket powder remains much higher in comparison with other animal sources of protein. This study seeks to contribute to reduce cricket production costs by determining food conversion efficiency at different ages as a mean of establishing an optimal harvesting age. Two temperature treatments of 27 and 29 °C consisting of 27 groups of five crickets each were monitored weekly to measure food consumption and growth for a period of 10 and 9 weeks respectively. Data were used to calculate efficiency of conversion of ingested food (ECI) for each week and treatment. Crickets at 27 °C produced more biomass and adults were significantly larger than those developing at 29 °C. The peak individual weekly biomass gain was observed at the end of 8 weeks at 27 °C (87.9±8.1 mg) (mean ± SEM) and at the end of 6 weeks at 29 °C (51.4±7.1 mg). Mean ECI values during weeks 1 to 8 at 27 °C (20.7, 22.6, 22, 20.8, 21.6, 20.9, 20, and 16.5%) and weeks 1 to 6 at 29 °C (18, 24.4, 19.9, 18.9, 21.1, and 16.4%) did not differ significantly. Decline of ECI values was better explained by the increase in adult proportions than by mortality. The optimal age to harvest based on food consumption and cricket biomass gain ratios was at the end of 8 weeks at 27 °C and at the end of 6 weeks at 29 °C. An economic analysis resulted in slightly higher profits ($ 1.04 USD) per g of hatchling/year at 27 °C.