gebhart/patrepeval huggingface dataset:
Regression of hypertension-induced vascular hypertrophy by an ACE inhibitor and calcium antagonist in the spontaneously hypertensive rat. (1992)

This study was designed to investigate the effects of antihypertensive drugs on vascular hypertrophy and vascular angiotensin II in vivo in spontaneously hypertensive rats (SHR). Hydralazine (10 mg/kg/day), delapril (angiotensin converting enzyme inhibitor; 20 mg/kg/day), manidipine (calcium channel blocker; 10 mg/kg/day), and vehicle were given by gavage to four groups of SHR between 4 and 5 months of age. The aortic angiotensin II level was measured by highly sensitive radioimmunoassay coupled with high pressure liquid chromatography; aortic morphologic studies were performed. Each drug treatment effectively lowered blood pressure to the same level. However, the aortic wall thickness, medial-intimal areas, and wall to lumen ratio of abdominal aorta decreased significantly (p < 0.05, p < 0.01, p < 0.01, respectively) with delapril and manidipine but not hydralazine. Delapril significantly decreased aortic angiotensin II levels (p < 0.05), whereas manidipine treatment significantly increased them (p < 0.05). The aortic angiotensin II level was not changed by hydralazine. These results show that delapril and manidipine caused regression of hypertension-induced vascular hypertrophy in SHR. The probable mechanism of regression of aortic hypertrophy by delapril was inhibition of vascular angiotensin II formation, but the mechanism for manidipine was unclear.
Supplementary Table S5 from Integrated Genomic Characterization of the Human Immunome in Cancer (2023)

&lt;p&gt;Table S5. Small molecules that alter immunological gene expression signatures.&lt;/p&gt;
Tumor heterogeneity in neoplasms of breast, colon, and skin (2010)

Our observations imply that tumor heterogeneity could be seen as an independent parameter for determining the characteristics of tumors. In the context of more comprehensive usage of array CGH or genome sequencing in a clinical setting our study provides a new way to realize the full potential of tumor genetic analysis.
Necesidades de investigación: unos cuantos enfoques (2000)

Presentacion realizada en la Reunion de Consulta de Expertos de la OPS/OMS sobre Vacunas y Estrategias de Vacunacion en los Programas de Control y Erradicacion de la Brucelosis; 16-18 noviembre 1999.
CMOS integrated poly-sigemems accelerometer above 0.18 &#x00B5;m technology (2015)

The paper demonstrates the very first CMOS integrated monolithic MEMS (Micro Electro Mechanical System) accelerometer with SiGeMEMS technology on top of TSMC 0.18 μm CMOS technology. The developed SiGeMEMS technology shows the ability for integration above any standard foundry process. This has allowed us to build a surface micromachined accelerometer with a very small form factor. The accelerometer dimension, is one of the smallest of its kind for consumer application.. The total area of the accelerometer including the MEMS structure and the CMOS readout is 1.35 mm × 1.35 mm and the total thickness of the active device including MEMS and CMOS (excluding substrate ) is ~ 25 μm. Full functionality of the device is demonstrated with a sensitivity of ~0.14 volts/g This paper doesn't emphasize on the performance of an micro-accelerometer (merely serves as a test vehicle) but rather on technology development (SiGeMEMS above foundry CMOS).
Hydrophobic Particle Films Improve Tree Fruit Productivity (1998)

Hydrophobic particle film technology (HPF) is a developing pest control system for tree fruit production systems. Studies were established in Chile, and Washington, Pennsylvania, and West Virginia in the United States, to evaluate the effect of HPF technology on tree fruit yield and quality. Studies in Chile, Washington, and West Virginia demonstrated increased photosynthetic rate at the leaf level. Yield was increased in peaches (Chile) and apples (West Virginia), and fruit size was increased in apples (Washington and Pennsylvania). Increased red color in apple was demonstrated at all sites with reduced russetting and `Stayman' cracking in Pennsylvania. HPF technology appears to be an effective tool in reducing water and heat stress in tree fruit resulting in increased fruit quality.
Computed Tomographic Biomarkers in Idiopathic Pulmonary Fibrosis. The Future of Quantitative Analysis (2018)

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with great variability in disease severity and rate of progression. The need for a reliable, sensitive, and objective biomarker to track disease progression and response to therapy remains a great challenge in IPF clinical trials. Over the past decade, quantitative computed tomography (QCT) has emerged as an area of intensive research to address this need. We have gathered a group of pulmonologists, radiologists and scientists with expertise in this area to define the current status and future promise of this imaging technique in the evaluation and management of IPF. In this Pulmonary Perspective, we review the development and validation of six computer-based QCT methods and offer insight into the optimal use of an imaging-based biomarker as a tool for prognostication, prediction of response to therapy, and potential surrogate endpoint in future therapeutic trials.
Effects of the Endothelin Receptor Antagonist Bosentan on Hemodynamics, Symptoms and Functional Capacity in Japanese Patients With Severe Pulmonary Hypertension (2005)

Bosentan was well tolerated and improved the hemodynamics, symptoms, exercise capacity, and quality of life of Japanese patients with PAH. Thus, bosentan can be a valuable therapeutic option in Japanese patients.
Quantitative phase imaging method based on an analytical nonparaxial partially coherent phase optical transfer function (2016)

Multifilter phase imaging with partially coherent light (MFPI-PC) is a promising new quantitative phase imaging method. However, the existing MFPI-PC method is based on the paraxial approximation. In the present work, an analytical nonparaxial partially coherent phase optical transfer function is derived. This enables the MFPI-PC to be extended to the realistic nonparaxial case. Simulations over a wide range of test phase objects as well as experimental measurements on a microlens array verify higher levels of imaging accuracy compared to the paraxial method. Unlike the paraxial version, the nonparaxial MFPI-PC with obliquity factor correction exhibits no systematic error. In addition, due to its analytical expression, the increase in computation time compared to the paraxial version is negligible.
Polarization Of THz Emission From Gas Plasma Induced By Two-Color Arbitrarily Polarized Laser Pulses (2016)

We examined experimentally and theoretically polarization of THz radiation generated during dual-color (800nm+400nm) co-propagation of high-peak-power femtosecond laser pulses in gases. We reveal that THz radiation polarization is predominantly defined by the generation of the nonlinear photocurrent in the self – induced laser plasma and remains relatively stable with respect to the change of the initial polarization angle between the 800 nm and 400 nm light fields.
A Novel Solution to the ATT48 Benchmark Problem (2007)

A solution to the benchmark ATT48 Traveling Salesman Problem (from the TSPLIB95 library) results from isolating the set of vertices into ten open-ended zones with nine lengthwise boundaries. In each zone, a minimum-length Hamiltonian Path (HP) is found for each combination of boundary vertices, leading to an approximation for the minimum-length Hamiltonian Cycle (HC). Determination of the optimal HPs for subsequent zones has the effect of automatically filtering out non-optimal HPs from earlier zones. Although the optimal HC for ATT48 involves only two crossing edges between all zones (with one exception), adding inter-zone edges can accommodate more complex problems.
Characterization of New-Generation Silicon Photomultipliers for Nuclear Security Applications (2018)

Silicon photomultipliers have received a great deal of interest recently for use in applications spanning a wide variety of fields, including nuclear safeguards and nonproliferation. For nuclear-related applications, the ability of silicon photomultipliers to discriminate neutrons from gamma rays using pulse shape discrimination when coupled with certain organic scintillators is a characteristic of utmost importance. This work reports on progress characterizing the performance of twenty different silicon photomultipliers from five manufacturers with an emphasis on pulse shape discrimination performance and timing. Results are presented on pulse shape discrimination performance as a function of overvoltage for 6-mm x 6-mm silicon photomultipliers, and the time response to stilbene is characterized for silicon photomultipliers of three different sizes. Finally, comparison with a photomultiplier tube shows that some new-generation silicon photomultipliers can perform as well as photomultiplier tubes in neutron-gamma ray discrimination.
ChemInform Abstract: Rearrangement of Ammonium Ylides Produced by Intramolecular Reaction of Catalytically Generated Metal Carbenoids. Part 2. Stereoselective Synthesis of Bicyclic Amines. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
In Situ Self-Assembly of Silver Nanoparticles (2014)

We have found that the thermal decomposition of [Ag(O2CnH2n–1)]2, where n = 14, 16, 18, and 22, produces the ordered 3D nanostructure (supracrystals) directly during the chemical reaction, which makes it possible to obtain self-assembled structures in large quantities without requiring additional processing steps. The process of self-assembling of silver nanoparticles is characterized by TEM and in situ time-resolved SAXRD and WAXS data. The calculated unit-cell parameters of the fcc nanostructures formed correlate with the aliphatic chain length: these are 9.55 nm for silver myristate (n = 14), 9.8 nm for silver palmitate (n = 16), 10.46 nm for silver stearate (n = 18), and 12.5 nm for silver behenate (n = 22). Structural and morphological characteristics of supracrystals formed in situ during the thermal decomposition of silver carboxylates are found to be dependent on the sample heating rate. The self-assembled ordering of the silver nanoparticles was observed to begin at ∼180, and above ∼280 °C the supracrystalline structures begin to decompose.
High-accuracy continuous airborne measurements of greenhouse gases (CO 2 and CH 4 ) using the cavity ring-down spectroscopy (CRDS) technique (2010)

Abstract. High-accuracy continuous measurements of greenhouse gases (CO2 and CH4) during the BARCA (Balanço Atmosférico Regional de Carbono na Amazônia) phase B campaign in Brazil in May 2009 were accomplished using a newly available analyzer based on the cavity ring-down spectroscopy (CRDS) technique. This analyzer was flown without a drying system or any in-flight calibration gases. Water vapor corrections associated with dilution and pressure-broadening effects for CO2 and CH4 were derived from laboratory experiments employing measurements of water vapor by the CRDS analyzer. Before the campaign, the stability of the analyzer was assessed by laboratory tests under simulated flight conditions. During the campaign, a comparison of CO2 measurements between the CRDS analyzer and a nondispersive infrared (NDIR) analyzer on board the same aircraft showed a mean difference of 0.22±0.09 ppm for all flights over the Amazon rain forest. At the end of the campaign, CO2 concentrations of the synthetic calibration gases used by the NDIR analyzer were determined by the CRDS analyzer. After correcting for the isotope and the pressure-broadening effects that resulted from changes of the composition of synthetic vs. ambient air, and applying those concentrations as calibrated values of the calibration gases to reprocess the CO2 measurements made by the NDIR, the mean difference between the CRDS and the NDIR during BARCA was reduced to 0.05±0.09 ppm, with the mean standard deviation of 0.23±0.05 ppm. The results clearly show that the CRDS is sufficiently stable to be used in flight without drying the air or calibrating in flight and the water corrections are fully adequate for high-accuracy continuous airborne measurements of CO2 and CH4.
Encapsulating 111In in Nanocontainers for Scintigraphic Imaging: Synthesis, Characterization, and In Vivo Biodistribution (2009)

A new strategy for the radiolabeling of porous nanocontainers has been developed, and the first experiments in vivo are reported. Our approach consists of the use of nanometer-sized zeolites whose channels have been filled with the positively charged gamma-emitter (111)In(3+) via simple ion exchange. To avoid leaching of the isotope under physiological conditions, the entrances of the channels have been closed using a specifically designed molecular stopcock. This stopcock has a positively charged group that enters the channels and entraps the loaded radionuclides via electrostatic and steric repulsion. The other side of the stopcock is a bulky triethoxysilane group that can covalently bind to the walls of the zeolite entrances, thereby irreversibly closing the channels. The surface of the zeolites has been functionalized with different chemical groups in order to investigate the different biodistributions depending of the nature of the functionalizations. Preliminary in vivo experiments with Wistar rats have been performed and showed the potential of the approach. This strategy leads to a nanoimaging probe with a very high density of radioisotopes in a confined space, which is highly stable in physiological solution and could allow a large variety of functionalities on its external surface.
Cooperative interactions among subunits of a voltage-dependent potassium channel. Evidence from expression of concatenated cDNAs. (1992)

Four copies of the coding sequence for a voltage-dependent potassium channel (RBK1, rat Kv1.1) were ligated contiguously and transcribed in vitro. The resulting RNA encodes four covalently linked subunit domains ([4]RBK1). Injection of this RNA into Xenopus oocytes resulted in the expression of voltage-dependent potassium currents. A single amino acid substitution, Tyr-->Val, located within the outer mouth of the pore, introduced into the equivalent position of any of the four domains, reduced affinity for external tetraethylammonium by approximately the same amount. In constructs containing 0, 1, 2, 3, or 4 Tyr residues the free energy of binding tetraethylammonium was linearly related to the number of Tyr residues. A different amino acid substitution, Leu-->Ile, located in the S4 region, was made in the equivalent position of one, two, three, or four domains. The depolarization required for channel activation increased approximately linearly with the number of Ile residues, whereas models of independent gating of each domain predict marked nonlinearity. Expression of this concatenated channel provides direct evidence that voltage-dependent potassium channels have four subunits positioned symmetrically around a central permeation pathway and that these subunits interact cooperatively during channel activation.
Advanced baseband technology in third-generation radio base stations (2003)

The functionality of a radio base station (RBS) is divided into two main parts: userplane functions and control-plane functions. The user-plane functions are associated with transport, baseband, radio and the antenna. The control-plane functions pertain to the transmission of user data and operation and maintenance (O&M) data. Ericsson’s RBS is based on the connectivity packet platform (CPP, formerly called Cello packet platform)—that is, the RBS employs the infrastructure of hardware and software modules provided in CPP. Figure 1 shows a typical indoor RBS with power subrack, baseband subrack, radio frequency subrack and power amplifier subrack. User-plane signals from the radio network controller (RNC) via the Iub interface are input directly via CPP boards to the baseband parts, whereas control-plane signals are input to the baseband parts via the traffic and O&M control parts of the main processor. Figure 2 shows the architecture of the Ericsson RBS3000. Please note that for simplicity’s sake the CPP parts and main processor are not shown. The architecture can be broken down into a cell-specific part and a non-cell-specific part. The cell-specific part contains transceiver (TRX) boards, multicarrier power amplifier (MCPA) boards and antenna interface unit (AIU) boards, whereas the common part contains boards for baseband processing. In Figure 2, the baseband processing has been split between the transmitter (TX) and random access and receiver (RAX) boards. The TX board handles downlink processing and enables coding, spreading and modulation. The RAX board handles uplink processing and enables demodulation, de-spreading and decoding.
Polysemy in a Broad-Coverage Natural Language Processing System (2000)

Abstract MS-NLP is a broad-coverage natural language understanding system that has been under development in Microsoft Research since 1991. Perhaps the most notable characteristic of this effort has been its emphasis on arbitrarily broad coverage of natural language phenomena. The system’s goal is to produce a useful linguistic analysis of any piece of text passed to it, regardless of whether that text is formal business prose, casual email, or technical writing from an obscure scientific domain. This emphasis on handling any sort of input has had interesting implications for the design of morphological and syntactic processing. Equally interesting, though, are its implications for semantic processing. The issue of polysemy and the attendant practical task of word sense disambiguation (WSD) take on entirely new dimensions in the context of a system like this, where a word might have innumerable possible meanings. A starting assumption, for example, is that MS-NLP will routinely have to interpret words and technical word senses that are not described in standard reference dictionaries.
Inspiration Induced by Phrenic Nerve Stimulation Increases Internal Defibrillation Energy Requirements (1999)

Inspiration induced by phrenic stimulation results in a 31% increase in the E50 compared with expiration. The decrease in shock efficacy occurs in the absence of a change in impedance. Active inspiration may alter the distribution of the electrical field leading to a decrease in shock efficacy.
Profilin is required for viral morphogenesis, syncytium formation, and cell-specific stress fiber induction by respiratory syncytial virus (2003)

Profilin plays a cardinal role in RSV-mediated cell fusion and viral maturation. In contrast, interaction of profilin with the viral transcriptional proteins P and N may only nominally activate viral RNA-dependent RNA polymerase. Stress fiber formation is a cell-specific response to infection, requiring profilin and perhaps other signaling molecules that are absent in certain cell lines. Stress fibers per se play no role in RSV replication in cell culture. Clearly, the cellular architecture controls multiple steps of host-RSV interaction, some of which are regulated by profilin.
Detection of demyelination in multiple sclerosis by analysis of T 2 * relaxation at 7 T (2015)

Multiple sclerosis (MS) is a relatively common cause of inflammatory demyelinating lesions of the central nervous system. In an attempt to detect and characterize ongoing demyelination in MS patient brains, we used a novel magnetic resonance imaging (MRI) technique, involving the fitting of a three-component model to the [Formula: see text] relaxation behavior at high-field (7 T). This model allowed estimation of the amount of myelin water (and thus indirectly myelin content), axonal water, and interstitial water. In this study, 25 relapsing-remitting MS patients underwent a 7 T MRI from which 12 gadolinium-enhancing lesions, 61 non-enhancing lesions, and their corresponding contralateral normal appearing white matter (NAWM) regions were analyzed. In both enhancing and non-enhancing lesions, the amplitude of myelin water was significantly decreased, and interstitial and axonal water were increased relative to the contralateral NAWM. Longer relaxation time [Formula: see text] of interstitial and axonal water, and lower frequency shift of axonal water, were also observed in both enhancing and non-enhancing lesions when compared to the contralateral NAWM. No significant difference was found between enhancing lesions and non-enhancing lesions. These findings suggest that the fitting of a three-component model to the [Formula: see text] decay curve in MS lesions may help to quantify myelin loss.
Structural Dependence of Nonlinear Characteristics in Coupled Resonator Optical Waveguides Based on Slotted Nanobeam Cavities (2013)

We propose coupled resonator optical waveguides based on slotted nanobeam cavities. We show that our proposed structure can achieve a high effective nonlinear coefficient because of small group velocity and light confinement in slot region.
Análisis del desprendimiento del concreto en conectores de cortante tipo tornillo sometidos a tracción (2020)

Magister en Ingenieria - Estructuras.
Linea de Investigacion: Analisis y Diseno Estructural.
Modulation of the Photoluminescence of Semiconductors by Surface Adduct Formation: An Application of Inorganic Photochemsitry to Chemical Sensing (1997)

Semiconductors provide a unique perspective on inorganic photochemistry. The electronic structure of common semiconductors permits a coupling of optical and electrical phenomena. As a consequence, semiconductors have found widespread use in many common electro-optical devices, including light-emitting-diodes (LEDs), diode lasers, and solar cells. In the case of LEDs and diode lasers, electrical excitation produces a highly emissive excited states of the solid; in contrast, in solar cells, photoexcitation can produce an eletrical output.
Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat (2001)

Tamoxifen (TAM), a widely used non-steroidal anti-estrogen, has recently been shown to be neuroprotective in a rat model of reversible middle cerebral artery occlusion (rMCAo). Tamoxifen has several potential mechanisms of action including inhibition of the release of excitatory amino acids (EAA) and nitric oxide synthase (NOS) activity. The question addressed in this study was whether TAM reduces ischemia-induced production of nitrotyrosine, considered as a footprint of the product of nitric oxide and superoxide, peroxynitrite. In rat brain, 2 h rMCAo produced a time-dependent increase in nitrotyrosine content in the cerebral cortex, as measured by Western blot analysis. Compared with vehicle, TAM significantly reduced nitrotyrosine levels in the ischemic cortex at 24 h. The neuronal (n)NOS inhibitor, 7-nitroindazole also tended to reduce nitrotyrosine, but this reduction was not statistically significant. Immunostaining for nitrotyrosine was seen in cortical neurons in the MCA territory and this immunostaining was reduced by TAM. In vitro, TAM and the calmodulin inhibitor trifluoperazine inhibited, with similar EC(50) values, the activity of recombinant nNOS as well as NOS activity in brain homogenates, measured by conversion of [(3)H]arginine to [(3)H]citrulline. There was marginal inhibition of recombinant inducible (i)NOS activity up to 100 microM TAM. These data suggest that TAM is an effective inhibitor of Ca(2+)/calmodulin-dependent NOS and the derived peroxynitrite production in transient focal cerebral ischemia and this may be one mechanism for its neuroprotective effect following rMCAo.
Upstream FEC performance in combination with burst mode receivers for next generation 10 Gbit/s PON (2010)

FEC gain in DC-coupled burst mode receivers is limited because of a variance in BER between bursts. This BER variance is characterized in an XG-PON1 upstream prototype. It is shown that basic BER tests overestimate the FEC gain.