gebhart/patrepeval huggingface dataset:
A new model for multi-commodity macroscopic modeling of complex traffic networks (2015)

We propose a macroscopic modeling framework for a network of roads and multi-commodity traffic. The proposed framework is based on the Lighthill-Whitham-Richards kinematic wave theory; more precisely, on its discretization, the Cell Transmission Model (CTM), adapted for networks and multi-commodity traffic. The resulting model is called the Link-Node CTM (LNCTM). In the LNCTM, we use the fundamental diagram of an "inverse lambda" shape that allows modeling of the capacity drop and the hysteresis behavior of the traffic state in a link that goes from free flow to congestion and back. A model of the node with multiple input and multiple output links accepting multi-commodity traffic is a cornerstone of the LNCTM. We present the multi-input-multi-output (MIMO) node model for multi-commodity traffic that supersedes previously developed node models. The analysis and comparison with previous node models are provided. Sometimes, certain traffic commodities may choose between multiple output links in a node based on the current traffic state of the node's input and output links. For such situations, we propose a local traffic assignment algorithm that computes how incoming traffic of a certain commodity should be distributed between output links, if this information is not known a priori.
Do Design à Criatividade (ou Vice-Versa): A Inovação Contextualizada nas Biotecnologias de Aprimoramento Humano a Partir de um Olhar Sistemático (2022)

O presente estudo visa apresentar uma revisão sistemática qualitativa sobre as relações entre as variáveis dependentes da criatividade e as bases da inovação, explorando como o design e algumas ciências projetuais têm lidado com essas duas forças no tratamento e na tradução de problemas em produtos, usando como contexto o cenário do transumanismo e das biotecnologias de aprimoramento humano.
Pink1 Mediates the Protective Effects of Thyroid Hormone T3 in Hyperoxia-Induced Lung Injury (2019)

Hyperoxia can lead to respiratory failure and death. Our previous work demonstrates that oxidant and mitochondrial injury play a critical role in hyperoxia-induced acute lung injury (HALI). Recentl...
The Spaceborne Infrared Atmospheric Sounder (SIRAS) instrument incubator demonstration (2001)

This paper will discuss the design, development and test of the SIRAS spectrometer and potential applications to future Earth Science Misions.
Targeting of two effector protein classes to the type III secretion system by a HpaC‐ and HpaB‐dependent protein complex from Xanthomonas campestris pv. vesicatoria (2005)

The Gram-negative plant pathogenic bacterium Xanthomonas campestris pv. vesicatoria translocates effector proteins via a specialized type III secretion (TTS) system into the host cell cytosol. The efficient secretion of many effector proteins depends on the global TTS chaperone HpaB. Here, we identified a novel export control protein, HpaC, which significantly contributes to bacterial pathogenicity. Deletion of hpaC leads to a severe reduction in secretion of effector proteins and the putative type III translocon proteins HrpF and XopA. By contrast, secretion of the TTS pilus protein HrpE is not affected. We provide experimental evidence that HpaC differentiates between two classes of effector proteins. Using an in vivo reporter assay, we found that HpaC specifically promotes the translocation of the effector proteins XopJ and XopF1 into the plant cell, whereas AvrBs3 and XopC are efficiently translocated even in the absence of HpaC. Similar findings were obtained for HpaB. Inhibition of protein synthesis suggests that HpaB is involved in the secretion of stored effector proteins. Furthermore, protein-protein interaction studies revealed that HpaB and HpaC form an oligomeric protein complex and that they interact with members of both effector protein classes and the conserved TTS system component HrcV. Taken together, our data indicate that HpaB and HpaC play a central role in recruiting TTS substrates to the secretion apparatus.
Materials and Processes for High k Gate Stacks: Results from the FEP Transition Center (2006)

A wide variety of materials and processes for high k dielectrics and metal gate electrodes have been studied as replacements for poly-Si/SiO2 or SiON in advanced CMOS devices. Care must be taken with the interfacial layer to control not only the nitrogen content but its spatial location. Nanocrystallization of the high k dielectric and the corresponding formation of charge and trapping levels associated with defects in the dielectric present one of the current challenges. Control of the workfunction of the gate electrode is shown to depend on many variables, including oxygen content and the material used for the capping layer on the metal gate. The hafnium oxide family of materials, along with metal alloy gates, is seen to provide the best solution for equivalent oxide thicknesses (EOT's) &lt; 0.7 nm, but higher k dielectrics and thinner interfacial layers are needed below 0.7 nm.
Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at $\sqrt{s} = 7\ \mbox{TeV}$ with the ATLAS experiment (2012)

Abstract This paper describes an analysis of the angular distribution of W → eν and W → μν decays, using data from pp collisions at $\sqrt{s} = 7\ \mbox{TeV}$ recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb −1 . Using the decay lepton transverse momentum and the missing transverse momentum, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f 0 , f L and f R over two ranges of W transverse momentum $(p_{\mathrm{T}}^{W} ): 35 &lt; p_{\mathrm{T}}^{W}&lt; 50\ \mbox{GeV}$ and $p_{\mathrm{T}}^{W}&gt; 50\ \mbox{GeV}$ . Good agreement is found with theoretical predictions. For $p_{\mathrm{T}}^{W}&gt; 50\ \mbox{GeV}$ , the values of f 0 and f L − f R , averaged over charge and lepton flavour, are measured to be: f 0 =0.127±0.030±0.108 and f L − f R =0.252±0.017±0.030, where the first uncertainties are statistical, and the second include all systematic effects.
A new family of active antiislanding schemes based on DQ implementation for grid-connected inverters (2004)

Unintentional islanding protection of distributed generation is a key function for standards compliance. For those distributed generations that use an inverter as grid interface, the function can be implemented as part of the inverter control. Existing antiislanding schemes used in inverters have power quality and nondetection zone issues. This paper proposes a new family of schemes that have negligible power quality degradation and no nondetection zone. Design guidelines based on frequency-domain analysis is also provided. Finally, both simulation and experimental results validate the proposed schemes.
Enabling Device to Device Broadcast for LTE Cellular Networks (2015)

In recent years, the public safety community has been aligning behind Long Term Evolution (LTE) technology as the basis for next generation public safety networks. Correspondingly, the 3rd Generation Partnership Project (3GPP) standards body has started multiple technical work initiatives on LTE enhancements to better support public safety use cases and requirements. Of particular importance to the public safety community is the addition of direct device-to-device (D2D) broadcast capability that can enable off-network push-to-talk (PTT) group communications in a manner equivalent to existing public safety communication systems. In this paper, we briefly explore the design objectives for, and challenges associated with, providing a D2D broadcast service. We then present and analyze a new distributed media access control (MAC) scheme for interference-aware coordination of both unicast and broadcast transmission. System-level simulation results are provided to validate the performance and the effectiveness of our approach, using a CSMA-based approach as a basis for comparison.
Impact of Organic Substrate Warp on C4 Non-Wets (2011)

Balancing the level of substrate warp at reflow with other sources contributing to C4 non-wets is an important problem. To address this, a methodology to predict the probability of non-wets during the chip attach process of an organic package has been developed. A technique for quantifying the convex or concave warp of a substrate in the form of a shape inversion (SI) plot is introduced. Geometrical factors that influence non-wets, such as C4 height, solder pad relative location, collapsed solder height etc., are described and their individual contributions to the non-wet conditions are computed. Combining these contributions onto the SI plot allows for a graphical representation of the non-wet probability. The technique is applied to a product substrate and the results are compared with the actual yield observed during chip assembly.
Operator quantum error correction (2013)

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ChemInform Abstract: Selectivity of Anionic Activation by Fluoride Ion in Solid‐Liquid Systems. Synthesis of Tetramic Acids and 4‐Methylene‐1,3‐oxazolidin‐2‐ones. (1987)

Abstract When the reaction method A) is used, title compounds of type (II) and (VI) can be synthesized in good yields as shown in the scheme.
A Monte Carlo simulation of resonance radiation transport in the rare-gas–mercury positive column (1993)

A Monte Carlo simulation is presented for the transport of mercury 254 nm radiation in the cylindrical positive column of an argon-mercury fluorescent lamp. Of particular interest are factors influencing the fraction f of photons which, once initially created by electron impact excitation in the volume of the lamp, actually escape to the outer wall of the lamp rather than being lost to nonresonant quenching. Increases in f of up to ≊6%, reported earlier from a similar model [Anderson et al., Phys. Rev. A 31, 2968 (1985)], are confirmed for artificial increases in the abundance of the 196Hg isotope to ≊10%. Other manipulations of the isotopic mercury content are investigated here, but none increase f by more than a few percent. Externally applied axial magnetic fields up to 0.15 T are found to increase f by up to 15%.
Improved compression of network coding vectors using erasure decoding and list decoding (2010)

Practical random network coding based schemes for multicast include a header in each packet that records the transformation between the sources and the terminal. The header introduces an overhead that can be significant in certain scenarios. In previous work, parity check matrices of error control codes along with error decoding were used to reduce this overhead. In this work we propose novel packet formats that allow us to use erasure decoding and list decoding. Both schemes have a smaller overhead compared to the error decoding based scheme, when the number of sources combined in a packet is not too small.
Raman Scattering from Finite Polytetrafluoroethylene Chains and a Highly Oriented TFE-HFP Copolymer Monofilament (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRaman Scattering from Finite Polytetrafluoroethylene Chains and a Highly Oriented TFE-HFP Copolymer MonofilamentJohn F. Rabolt and Bruno FanconiCite this: Macromolecules 1978, 11, 4, 740–745Publication Date (Print):July 1, 1978Publication History Published online1 May 2002Published inissue 1 July 1978https://pubs.acs.org/doi/10.1021/ma60064a025https://doi.org/10.1021/ma60064a025research-articleACS PublicationsRequest reuse permissionsArticle Views556Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Heterogeneous Catalysis with Nickel‐on‐Graphite (Ni/Cg): Reduction of Aryl Tosylates and Mesylates. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Colitis immunoregulation by CD8+T cell requires T cell cytotoxicity and B cell peptide antigen presentation (2008)

Deficient immunoregulation by CD4+ T cells is an important susceptibility trait for inflammatory bowel disease, but the role of other regulatory cell types is less understood. This study addresses the role and mechanistic interaction of B cells and CD8+ T cells in controlling immune-mediated colitis. The genetic requirements for B cells and CD8+ T cells to confer protective immunoregulation were assessed by cotransfer with colitogenic Galphai2-/- T cells into immune-deficient mice. Disease activity in Galphai2-/- T cell recipients was evaluated by CD4+ T intestinal lymphocyte abundance, cytokine production levels, and large intestine histology. B cells deficient in B7.1/B7.2, CD40, major histocompatibility complex (MHC) II (Abb), or native B cell antigen receptor (MD4) were competent for colitis protection. However, transporter-1-deficient B cells failed to protect, indicating a requirement for peptide MHC I presentation to CD8+ T cells. CD8+ T cells deficient in native T cell receptor repertoire (OT-1) or cytolysis (perforin-/-) also were nonprotective. These finding reveal an integrated role for antigen-specific perforin-dependent CD8+ T cell cytotoxicity in colitis immunoregulatory and its efficient induction by a subset of mesenteric B lymphocytes.
Sustained release of acetylcholine in rat hippocampus using a polyanhydride drug‐delivery system (1992)

Abstract A biodegradable polymer drug‐delivery system has been developed for the selective localized application of agents to brain parenchyma. The copolymer of poly[bis(p‐carboxyphenoxy)propane] anhydride and sebacic acid (PCPP–SA) was impregnated with [ 3 H]‐acetylcholine (ACh) to form 1–5 μm microspheres. Drug‐loaded microspheres were implanted into hippocampus bilaterally in 25 rats, and brain sections processed for autoradiography in groups of five animals at 2, 5, 10, 20 and 40 days, respectively. By densitometric analysis, the concentration of radiolabelled ACh in polymer and adjacent hippocampus rapidly decreased between 2 and 5 days, after which a gradual decrease in [ 3 H]‐ACh was observed up to 40 days. Between 2 and 40 days the concentration of radiolabelled ACh was reduced by 25.8% in polymer matrix and 40.1% in hippocampus. The spread of [ 3 H]‐label into adjacent brain parenchyma showed a similar temporal relationship, with initially wider dispersion at 2 days (44±3 μm), then a linear decrease in dispersion over the remaining period (10±0.9 μxm at 40 days), suggesting bulk flow of the radiolabel into hippocampus. Brain parenchyma showed only a minimal inflammatory reaction to the polyanhydride implants over all time periods. Polyanhydrides can provide localized continuous release of ACh to brain parenchyma, and may potentially be used to deliver various agents to brain in a number of clinical and experimental applications.
<title>Building terrain maps and virtual worlds from video imagery</title> (1998)

This paper is the result of Cybernet efforts starting in May of 1995 and currently on-going to develop system for capturing high resolution 3D terrain and cultural features from multiple position references video sequences. The notion is to test and implement a perception-based image rendering technique for terrain capture of real sites applicable to robotics, virtual reality and simulation applications. These techniques will enable the Army to better understand and evaluate the operational capabilities of vision based task performance. The proposed development effort has focused on the development and evaluation of image-based object constructions and rendering algorithms which will be summarized following.
Yield of Repeat Balloon-Assisted Enteroscopy in Small Bowel Bleeding (2016)

Introduction: Small bowel bleeding (SBB) accounts for 5-10% of all gastrointestinal bleeding (GIB) episodes. The long term rebleeding rate is high despite balloon assisted enteroscopy (BAE) directed therapy. There is a paucity of data on the yield of repeat BAE in SBB. The study aims were to: 1) determine the diagnostic yield (DY) and therapeutic yield (TY) of repeat BAE in SBB and 2) assess the clinical and endoscopic predictors of a positive repeat BAE. Methods: Review of a prospectively maintained endoscopy database from September 2006-August 2015 was performed. Patients who had > 1 BAE for an indication of overt or occult GIB were included. Data were abstracted for patient demographics, clinical presentation, co-morbidities, relevant medications, and BAE procedural details. Primary outcomes were the rate and predictors of a positive DY and TY of repeat BAE. Results: Out of 369 patients identified, 102 (55% men) with mean age of 63 ± 16 years met inclusion criteria. Initial BAE was performed via the antegrade route in 73% and utilizing a double balloon enteroscope (DBE) in 92% of cases. The DY of initial BAE was 43% with angiodysplasias (66%) as the most common finding. The TY was 41% with thermal monotherapy (88%) via argon plasma or bipolar coagulation as the most common treatment modality. The median time to repeat BAE was 52 days (range 0-1758). Occult re-bleeding was noted in 51%, melena in 41%, and hematochezia in 8%. Repeat BAE was performed via DBE in 99% (n=101), via antegrade route in 45% (n=46) and in the same route as initial BAE in 33% (n=34). The overall DY and TY of repeat BAE were 55% (n=56) and 40% (n=41), respectively (table 1). Thermal monotherapy was utilized in 85% (n=35), hemoclip monotherapy in 7.5% (n=3), and combination therapy in 7.5% (n=3). There was no significant difference between the positive and negative repeat BAE groups in terms of age, male gender and clinical presentation (table 1). Patients with positive findings were more likely to have cardiac comorbidities (49% vs 23%; p=0.007), chronic obstructive pulmonary disease (COPD) (29% vs. 3%; p < 0.001), aspirin use (46% vs. 21%; p=0.025), and positive TY on initial BAE (61% vs. 28%; p < 0.001).Figure 1Conclusion: Positive yield of repeat BAE for SBB is noted in approximately half of patients. Positive initial BAE, cardiac comorbidities, COPD, and aspirin use are significantly associated with a positive TY of repeat BAE.
Comparison of Properties of Membrane Bound Versus Soluble Forms of Human Leukocytic Elastase and Cathepsin G (1994)

Stimulation of human neutrophils with micromolar concentrations of N-formyl-methionyl-leucyl-phenyl-alanine (fMLP) or 4 beta-phorbol-12 beta-myristate-13 alpha-acetate (PMA), results in their degranulation and/or lysis with a concomitant release of Human Leucocyte Elastase (HLE; EC 3.4.21.37), Cathepsin G (cat G; EC 3.4.21.20) and Myeloperoxidase (MPO; EC 1.11.1.7) into the surrounding medium, some of which re-bind in an active form to neutrophil plasma membranes or membrane fragments. Histones, when present in the medium, prevent this association indicating that it is largely charge dependent. Bound proteinases have an increased resistance to inhibition by protein proteinase inhibitors, while bound MPO retains its ability to oxidatively inactivate alpha-1-proteinase inhibitor (alpha-1-PI). The attachment of oxidases and proteinases to plasma membrane or its fragments may allow them to remain active in an environment replete with proteinase inhibitors and, therefore, may be responsible for neutrophil or neutrophil-debris mediated tissue damage.
Lutein, a carotenoid, suppresses osteoclastic bone resorption and stimulates bone formation in cultures (2016)

Lutein, a member of the xanthophyll family of carotenoids, suppressed IL-1-induced osteoclast differentiation and bone resorption. The survival of mature osteoclasts was also suppressed by lutein in cultures. When lutein was added to the cultures of osteoblasts, lutein enhanced the formation of mineralized bone nodules by elevating BMP2 expression and inhibiting sclerostin expression. Lutein may be beneficial for bone health.
Homeoprotein Neuroprotection of Embryonic Neuronal Cells (2019)

Most homeoprotein transcription factors have a highly conserved internalization domain used in intercellular transfer. Internalization of homeoproteins ENGRAILED1 or ENGRAILED2 promotes the survival of adult dopaminergic cells, whereas that of OTX2 protects adult retinal ganglion cells. Here we characterize the <i>in vitro</i> neuroprotective activity of several homeoproteins in response to H<sub>2</sub>O<sub>2</sub> Protection is observed with ENGRAILED1, ENGRAILED2, OTX2, GBX2, and LHX9 on midbrain and striatal embryonic neurons, whereas cell-permeable c-MYC shows no protective effects. Therefore, five homeoproteins belonging to three different classes (ANTENNAPEDIA, PAIRED, and LIM) share the ability to protect embryonic neurons from midbrain and striatum. Because midbrain and striatal neurons do not express the same repertoire of the four proteins, a lack of neuronal specificity together with a general protective activity can be proposed. Interestingly, hEN1 and GBX2 provided protection to primary midbrain astrocytes but not to non-neural cells, including mouse embryo fibroblasts, macrophages or HeLa cells. For the four proteins, protection against cell death correlated with a reduction in the number of H<sub>2</sub>O<sub>2</sub>-induced DNA break foci in midbrain and striatal neurons. In conclusion, within the limit of the number of cell types and homeoproteins tested, homeoprotein protection against oxidative stress-induced DNA breaks and death is specific to neurons and astrocytes but shows no homeoprotein or neuronal type specificity.
Convenient microtiter plate‐based, oxygen‐independent activity assays for flavin‐dependent oxidoreductases based on different redox dyes (2013)

Flavin-dependent oxidoreductases are increasingly recognized as important biocatalysts for various industrial applications. In order to identify novel activities and to improve these enzymes in engineering approaches, suitable screening methods are necessary. We developed novel microtiter-plate-based assays for flavin-dependent oxidases and dehydrogenases using redox dyes as electron acceptors for these enzymes. 2,6-dichlorophenol-indophenol, methylene green, and thionine show absorption changes between their oxidized and reduced forms in the visible range, making it easy to judge visually changes in activity. A sample set of enzymes containing both flavoprotein oxidases and dehydrogenases - pyranose 2-oxidase, pyranose dehydrogenase, cellobiose dehydrogenase, D-amino acid oxidase, and L-lactate oxidase - was selected. Assays for these enzymes are based on a direct enzymatic reduction of the redox dyes and not on the coupled detection of a reaction product as in the frequently used assays based on hydrogen peroxide formation. The different flavoproteins show low Michaelis constants with these electron acceptor substrates, and therefore these dyes need to be added in only low concentrations to assure substrate saturation. In conclusion, these electron acceptors are useful in selective, reliable and cheap MTP-based screening assays for a range of flavin-dependent oxidoreductases, and offer a robust method for library screening, which could find applications in enzyme engineering programs.