gebhart/patrepeval huggingface dataset:
Impairment of the antegrade fast pathway in patients with atrioventricular nodal reentrant tachycardia can be functional and treated by slow pathway ablation: a case report study (2018)

Our cases illustrate a common dilemma when dealing with patients with AVNRT and prolonged baseline interval. We show that SP ablation is feasible and safe as long as a preserved antegrade FP is present.
Seismic interpretation and characterisation of igneous rocks in Jan Mayen microcontinent, Norwegian-Greenland sea (2016)

Magmatic activity during the Cenozoic break-up and the opening of the Norwegian-Greenland Sea is preserved in the Jan Mayen Microcontinent. As the emplacements of magmatic rocks on continental margins have implications for both petroleum and mineral exploration. This work is aimed at interpreting evidence of magmatic activity from seismic reflection data and how it influences the geodynamic evolution of the study area. Igneous rocks are interpreted as positive, high amplitude reflections which are also characterized by complex geometries, abrupt terminations in adjacent sediments, and local transgression across stratigraphy levels. In the study area, they are acoustically hard and are either concordant or discordant to sedimentary bedding. The two major seismic facies interpreted in the study area are a) irregular, bedding discordant, intrusive rock, i.e., dikes, saucer-shaped, and bowl-shaped intrusions and b) horizontal, layered, and bedding parallel positive reflections e.g., pillow basalts and tabular sills. The Jan Mayen microcontinent is delimited by these igneous rocks into a western margin rich in extrusive rocks and an eastern region characterized by intrusive igneous rocks. Volcanic sills in the study area can be mapped independently on seismic profiles. They are often associated with post-depositional deformation of the Paleocene rocks. Individual sills exhibit complex fragmentation and are found in close proximity of faults. Base on their interaction with volcanic sills, faults in the study area can be grouped as deep-seated and hard-linked faults, intermediate and shallow faults. The important piece of information from this work is that magmatic intrusions influenced configuration of faults and are sued as the major control on structural reactivation in the study area. The volcanic rocks in Jan Mayen microcontinent were emplaced in Early Eocene during the opening of the southern Greenland Sea. A second phase of volcanic emplacement is related to re-configuration of plate orientation and motion in Oligocene times
Planar Hall bead array counter microchip with NiFe/IrMn bilayers (2008)

The planar Hall effect (PHE) magnetic bead array countermicrochip integrating 24 of single sensors based on a simple NiFe/IrMn bilayer structure with a patterned size of 3×3 μm2 has been fabricated and characterized. Single PHE sensors exhibit a sensitivity of about 2.5 mΩ/Oe. It was well applied for single Dynabeads® M-280 detection, where one bead can induce a signal change, ΔV∼2.2 mV, under the applied magnetic field of 20 Oe and a sensing current of 2 mA. This type of microchip is promising for quickly detecting and identifying multiple biological agents in the environment.
Failed Back Surgery Syndrome: 5-Year Follow-Up in 102 Patients Undergoing Repeated Operation (1991)

The indications for repeated operation in patients with persistent or recurrent pain after lumbosacral spine surgery are not well established. Long-term results have been reported infrequently, and in no case has mean follow-up exceeded 3 years. We report 5-year mean follow-up for a series of repeated operations performed between 1979 and 1983. Patient characteristics and modes of treatment have been assessed as predictors of long-term outcome. One hundred two patients with "failed back surgery syndrome" (averaging 2.4 previous operations), who underwent a repeated operation for lumbosacral decompression and/or stabilization, were interviewed by a disinterested third party a mean of 5.05 years postoperatively. Successful outcome (at least 50% sustained relief of pain for 2 years or at last follow-up, and patient satisfaction with the result) was recorded in 34% of patients. Twenty-one patients who were disabled preoperatively returned to work postoperatively; 15 who were working preoperatively became disabled or retired postoperatively. Improvements in activities of daily living were recorded, overall, as often as decrements. Loss of neurological function (strength, sensation, bowel and bladder control) was reported by patients more often than improvement. Most patients reduced or eliminated analgesic intake. Statistical analysis (including univariate and multivariate logistic regression) of patient characteristics as prognostic factors showed significant advantages for young patients and for female patients. Favorable outcome also was associated with a history of good results from previous operations, with the absence of epidural scar requiring surgical lysis, with employment before surgery, and with predominance of radicular (as opposed to axial) pain.(ABSTRACT TRUNCATED AT 250 WORDS)
Molecular genetic approaches to the pathogenesis of bacillary dysentery. (1988)

Bacillary dysentery is an invasive infectious disease of the human colon. At least three genetic loci on the chromosome and a huge plasmid have been implicated in its pathogenesis. Results obtained from molecular genetic studies, mainly of the genes, virG, virF and kcpA are discussed.
Inactivation of Junctional Adhesion Molecule-A Enhances Antitumoral Immune Response by Promoting Dendritic Cell and T Lymphocyte Infiltration (2010)

Junctional adhesion molecule-A (JAM-A)-null dendritic cells (DCs) are more motile and effective than their wild-type counterpart in promoting contact hypersensitivity reaction. Here, we show that the growth and aggressiveness of pancreatic islet cell carcinoma induced by SV40 T antigen expression in beta cells (Rip1Tag2 mice) are significantly reduced in JAM-A-null mice. Because these tumor cells do not express JAM-A, we focused on changes in stroma reactivity. In the absence of JAM-A, tumors showed a small but significant reduction in angiogenesis and a marked increase in the immune reaction with enhanced infiltration of DCs (CD11c+ and MHC-II+) and CD4+ and CD8+ lymphocytes. In contrast, phagocyte number was not affected. DC capacity to produce cytokines was not significantly altered, but transmigration through JAM-A-null endothelial cells was increased as compared with JAM-A-positive endothelium. On adoptive transfer, JAM-A(-/-) DCs were recruited to tumors at slightly but significantly higher rate than JAM-A(+/+) DCs. Ablation of CD4+ and CD8+ cells with specific antibodies abrogated the inhibitory effect of JAM-A deletion on tumor growth and angiogenesis. These findings support the idea that, in the Rip1Tag2 tumor model, abrogation of JAM-A reduces cancer development by increasing antitumor immune response.
Discrimination of Cultivars and Cultivation Origins from the Sepals of Dry Persimmon Using FT-IR Spectroscopy Combined with Multivariate Analysis (2015)

본 연구에서는 상업용 곶감의 꽃받침과 종자를 이용하여 대사체 수준에서의 원산지와 품종 식별 체계를 확립하였다. 실험에 이용된 곶감 시료는 국내산 곶감 함안수시(Hamansusi), 예천고종시(Yecheongojongsi), 산청단성시(Sancheongdanseongsi), 그리고 논산월하시(Nonsanwalhasi) 4개 품종과 국내에서 판매되고 있는 중국산 곶감 2개 종류의 꽃받침과 종자를 사용하였으며, 꽃받침과 종자 시료의 전세포 추출물로부터 FT-IR 스펙트럼 데이터를 기반으로 다변량 통계분석(PCA, PLS-DA)을 실시하였다. 이 결과 국내산 곶감 4품종과 중국산 곶감 2종류가 두 그룹으로 확연히 나뉘어지는 것을 확인할 수 있었다. 상업용 곶감의 꽃받침을 PLS regression을 실시한 결과 국내산과 중국산 곶감을 100% 예측할 수 있었다. 또한 곶감 종자를 이용하여 품종 식별한 결과 각 4개의 그룹으로 나뉘어지는 것을 확인할 수 있었으며, PLS regression을 실시한 결과 약 86%의 정확도로 품종 식별이 가능함을 알 수 있었다. FT-IR 스펙트럼 분석의 간편성과 신속성을 고려할 때, 본 연구 결과는 상업용 곶감에 대한 원산지나 품종 식별의 신속한 수단으로 활용할 수 있을 것으로 예상된다. 더 나아가 본 기술을 이용하여 다른 농산물의 원산지 또는 품종 식별 수단으로 활용이 가능할 것으로 기대된다. This study aimed to establish a rapid system for discriminating the cultivation origins and cultivars of dry persimmons, using metabolite fingerprinting by Fourier transform infrared (FT-IR) spectroscopy combined with multivariate analysis. Whole-cell extracts from the sepals of four Korean cultivars and two different Chinese dry persimmons were subjected to FT-IR spectroscopy. Principle component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) of the FT-IR spectral data successfully discriminated six dry persimmons into two groups depending on their cultivation origins. Principal component loading values showed that the 1750-1420 and <TEX>$1190-950cm^{-1}$</TEX> regions of the FT-IR spectra were significantly important for the discrimination of cultivation origins. The accuracy of prediction of the cultivation origins and cultivars by PLS regression was 100% (p<0.01) and 85.9% (p<0.05), respectively. These results clearly show that metabolic fingerprinting of FT-IR spectra can be applied for rapid discrimination of the cultivation origins and cultivars of commercial dry persimmons.
TLR4, Ethanol, and Lipid Rafts: A New Mechanism of Ethanol Action with Implications for other Receptor-Mediated Effects (2007)

Ethanol (EtOH) is the most widely abused substance in the United States, and it contributes to well-documented harmful (at high dosages) and beneficial (at low dosages) changes in inflammatory and immune responses. Lipid rafts have been implicated in the regulation and activation of several important receptor complexes in the immune system, including the TLR4 complex. Many questions remain about the precise mechanisms by which rafts regulate the assembly of these receptor complexes. Results summarized in this review indicate that EtOH acts by altering the LPS-induced redistribution of components of the TLR4 complex within the lipid raft and that this is related to changes in actin cytoskeleton rearrangement, receptor clustering, and subsequent signaling. EtOH provides an example of an immunomodulatory drug that acts at least in part by modifying lipid rafts, and it could represent a model to probe the relationships between rafts, receptor complexes, and signaling.
Reliability and Reproducibility of QRS Duration in the Selection of Candidates for Cardiac Resynchronization Therapy (2010)

Manual QRS duration measurements were associated with significant inter- and intraobserver variability and low concordance with computerized measurements. The measurement of QRS is, therefore, operator-dependent and a reevaluation of the measurement methods may be essential to develop clinical and investigative standards.
Solid phase extraction and ultra performance liquid chromatography-tandem mass spectrometric identification of carcinogenic/mutagenic heterocyclic amines in cooked camel meat (2014)

In the present study, three kinds of camel (Mjahim, Mgatir and Humor) from Saudi Arabia have been studied for heterocyclic amines (HAs) contents in their cooked meat.
CD28:B7 BLOCKADE PREVENTS TRANSPLANT VASCULOPÁTHY AND MONONUCLEAR CELL INFILTRATION IN A FULLY ALLOGENEIC CARDIAC TRANSPLANT MODEL (1998)

138 CTLA4Ig is a recombinant fusion protein that inhibits T cell activation by blocking the CD28:B7 interaction and is known to prevent acute rejection and induce long term graft acceptance in animal models. We have previously reported that CTLA4Ig prevents chronic rejection in the non-fully allogeneic F344 to LEW model. The aim of the current study is to assess the impact of CTLA4Ig in a more clinically relevant fully allogeneic cardiac allograft model with specific reference to mixed lymphocyte reactivity, CD8+ cytotoxicity, donor-specific allo-antibody production, and long term graft morphology. LEW rats were challenged with WF cardiac allografts. A single dose of 0.5mg CTLA4Ig in conjunction with the iv administration of 4×107 donor specific spleen cells induced long term graft acceptance in 50% of the recipients (n=12). At the timepoint of acute rejection (day+7) lymphocytes from CTLA4Ig treated animals showed significant reductions in donor specific mixed lymphocyte reactivity (Relative Response: 0.03 against WF, 0.7 against BN), compared to acutely rejecting unmodified controls. The anti-donor CTL generation/function was almost completely abolished (controls 29.1% lysis, CTLA4Ig 1.2% lysis). Flow cytometric studies of serum samples revealed profound inhibition of anti-donor allo-antibody responses. Morphometric analysis of grafts explanted at 150 days was performed using a semiquantitive scoring system in which graft vascular lesions were scored from 0 (no lesions) to 5 (severe lesions). Minimal transplant vasculopathy developed in both CTLA4Ig treated animals as well as isograft controls (Score 0.83±0.1 vs. 0.37±0.2, p=NS). In contrast, LEW recipients of WF cardiac allografts treated with long term cyclosporine (25mg/day for 14 days, thereafter 5mg/day) developed severe transplant vasculopathy (score: 2.4±0.4, p<0.05 against CTLA4Ig treated animals). After 150 days immunohistochemical analysis from grafts of CTLA4Ig treated animals showed a significantly reduced degree of T-cell infiltrates (p<0.001) as well as monocyte/macrophage infiltrates (p<0.001), as compared to cyclosporine treated animals. These results indicate that T cell costimulatory blockade induces long term graft acceptance by modulating the effector mechanisms of rejection in a fully allogeneic cardiac transplant model. More importantly, CTLA4Ig prevented the development of transplant vasculopathy compared with the long term administration of cyclosporine. This is of special interest, as clinical studies with CTLA4Ig are planned.
Revamping Cross-Modal Recipe Retrieval with Hierarchical Transformers and Self-supervised Learning (2021)

Cross-modal recipe retrieval has recently gained substantial attention due to the importance of food in people's lives, as well as the availability of vast amounts of digital cooking recipes and food images to train machine learning models. In this work, we revisit existing approaches for cross-modal recipe retrieval and propose a simplified end-to-end model based on well established and high performing encoders for text and images. We introduce a hierarchical recipe Transformer which attentively encodes individual recipe components (titles, ingredients and instructions). Further, we propose a self-supervised loss function computed on top of pairs of individual recipe components, which is able to leverage semantic relationships within recipes, and enables training using both image-recipe and recipe-only samples. We conduct a thorough analysis and ablation studies to validate our design choices. As a result, our proposed method achieves state-of-the-art performance in the cross-modal recipe retrieval task on the Recipe1M dataset. We make code and models publicly available.
Brain natriuretic peptide is removed by continuous veno-venous hemofiltration in pediatric patients (2009)

We wanted to evaluate if brain natriuretic peptide (BNP) is cleared during continuous veno-venous hemofiltration (CVVH) sessions in children with congenital heart disease. A prospective observational single-center study was conducted in a post-cardiac surgery intensive care unit of the city children's hospital. Ten children requiring CVVH for acute kidney injury following cardiac surgery were enrolled. Seven of them were undergoing postoperative extracorporeal membrane oxygenation. BNP clearance was evaluated by the difference between pre-filter and post-filter BNP blood amount indexed to pre-filter BNP concentration. All CVVH treatments were performed with 0.6 m2 polyacrylonitrile filter, in predilution setting, at a dose of 80 ml/kg/h. Troponin I and myoglobin levels were also measured and CVVH clearances of these markers calculated for comparison with BNP. A significant decrease in post-filter compared with pre-filter levels of BNP was shown in all 10 cases (P<0.01). Median BNP clearance was 35.6 (29-39.3) ml/min. Troponin I and myoglobin levels did not show any significant drop between pre- and post-filter values (P>0.05) and their clearance was significantly lower than BNP (P: 0.0004). A daily analysis of BNP levels showed a significant decrease of its blood concentration. BNP levels were significantly reduced after three and four days from CVVH start (P<0.05). During 80 ml/kg/h CVVH, utilizing polyacrylonitrile membranes, BNP is efficiently cleared from blood in a small cohort of pediatric post-cardiosurgical patients. In this situation, BNP absolute blood levels may be unpredictable.
An in vitro platform for study of the human gut microbiome under an oxygen gradient (2023)

The complex, dynamic environment of the human lower gastrointestinal tract is colonized by hundreds of bacterial species that impact health and performance. Ex vivo study of the functional interactions between microbial community members in conditions representative of those in the gut is an ongoing challenge. We have developed an in vitro 40-plex platform that provides an oxygen gradient to support simultaneous maintenance of microaerobic and anaerobic microbes from the gut microbiome that can aid in rapid characterization of microbial interactions and direct comparison of individual microbiome samples. In this report, we demonstrate that the platform more closely maintained the microbial diversity and composition of human donor fecal microbiome samples than strict anaerobic conditions. The oxygen gradient established in the platform allowed the stratification and subsequent sampling of diverse microbial subpopulations that colonize microaerobic and anaerobic micro-environments. With the ability to run forty samples in parallel, the platform has the potential to be used as a rapid screening tool to understand how the gut microbiome responds to environmental perturbations such as toxic compound exposure, dietary changes, or pharmaceutical treatments.
Concepts in Syngas Manufacture (2011)

Basic Principles:Syngas Manufacture Syngas Applications Steam Reforming Technology:Technology of Steam Reforming Carbon and Sulphur Catalysis of Steam Reforming
Latest evolution in a 300mm graphoepitaxy pilot line flow for L/S applications (2017)

Directed Self Assembly (DSA) of block-copolymers (BCPs) used as a complementary technique to the 193nm immersion lithography has demonstrated sub-10nm node applications in both via and line/space patterning. We propose however to study the performance of graphoepitaxy which allows DSA with thicker initial BCP layer, higher multiplication factors and stronger orientation control of lamellae. The aim of this work is to use the 300mm pilot line available at LETI and Arkema’s advanced materials to evaluate the performances of a novel graphoepitaxy process based on the work on a 38nm period lamellar PS-<i>b</i>-PMMA (L38) reported before.
Semiconductor analysis using organic-on-inorganic contact barriers. I. Theory of the effects of surface states on diode potential and ac admittance (1986)

A new method for measuring the density of states at semiconductor surfaces using organic-on-inorganic (OI) semiconductor contact barriers is suggested. This work is an extension of previous models of OI diode behavior which includes the ac admittance characteristics, and which considers the range of validity of approximations to OI diode capacitance used in previous experiments. The theory describes the potential distribution across the device. We consider the case of ideal OI diodes, as well as diodes with significant densities of states at the inorganic semiconductor surface. This analysis leads to a technique whereby the low-frequency conductance and capacitance characteristics can be used to obtain information about the magnitude and the energy distribution of surface states in the inorganic semiconductor bandgap. Also, the carrier concentration profiles of the substrate can be conveniently obtained. Due to the noninvasive nature of the organic/inorganic contact, information about the density of states at relatively undisturbed semiconductor surfaces obtained via this technique may prove useful in determining the processes involved in Schottky barrier formation and metal-insulator-semiconductor diode surface properties. This theory has been applied to the investigation of surfaces of III-V alloy semiconductor-based OI diodes, and the experimental results will be presented in a subsequent paper. In addition, an expression for the OI diode n value obtained from the forward current-voltage characteristics is derived. It is found that the n value depends on surface states which are in equilibrium with the organic as well as the inorganic materials. Estimates of the surface state densities obtained from previously reported n values are consistent with expectations for the semiconductors under test.
Comparison of the Quality of Oral Anticoagulant Therapy Through Patient Self-management and Management by Specialized Anticoagulation Clinics in the Netherlands (2003)

With selected patients, the quality of OAT obtained through patient self-management is at least as high as that delivered by specialized physicians at anticoagulation clinics. Weekly management of OAT with long-acting phenprocoumon has to be preferred at anticoagulation clinics or, where possible, through patient self-management.
MULTIMODALITY TREATMENT OF GIANT INTRACRANIAL ARTERIOVENOUS MALFORMATIONS (2007)

Chang, Steven D. M.D.; Marcellus, Mary L. R.N.; Marks, Michael P. M.D.; Levy, Richard P. M.D., Ph.D.; Do, Huy M. M.D.; Steinberg, Gary K. M.D., Ph.D.
Fabrication of 8K4K organic EL panel using high‐mobility IGZO material (2015)

Abstract A 13.3‐inch 8k4k organic light‐emitting diode display based on a newly developed high‐mobility indium–gallium–zinc–oxide material was fabricated. It was found that the use of a higher‐mobility material decreases the scan driver size and power consumption. Furthermore, such oxide semiconductor layers with a buried channel structure can increase process stability and reliability.
First-principles experimental demonstration of ferroelectricity in a thermotropic nematic liquid crystal: Polar domains and striking electro-optics (2020)

We report the experimental determination of the structure and response to applied electric field of the lower-temperature nematic phase of the previously reported calamitic compound 4-[(4-nitrophenoxy)carbonyl]phenyl2,4-dimethoxybenzoate (RM734). We exploit its electro-optics to visualize the appearance, in the absence of applied field, of a permanent electric polarization density, manifested as a spontaneously broken symmetry in distinct domains of opposite polar orientation. Polarization reversal is mediated by field-induced domain wall movement, making this phase ferroelectric, a 3D uniaxial nematic having a spontaneous, reorientable polarization locally parallel to the director. This polarization density saturates at a low temperature value of ∼6 µC/cm<sup>2</sup>, the largest ever measured for a fluid or glassy material. This polarization is comparable to that of solid state ferroelectrics and is close to the average value obtained by assuming perfect, polar alignment of molecular dipoles in the nematic. We find a host of spectacular optical and hydrodynamic effects driven by ultralow applied field (E ∼ 1 V/cm), produced by the coupling of the large polarization to nematic birefringence and flow. Electrostatic self-interaction of the polarization charge renders the transition from the nematic phase mean field-like and weakly first order and controls the director field structure of the ferroelectric phase. Atomistic molecular dynamics simulation reveals short-range polar molecular interactions that favor ferroelectric ordering, including a tendency for head-to-tail association into polar, chain-like assemblies having polar lateral correlations. These results indicate a significant potential for transformative, new nematic physics, chemistry, and applications based on the enhanced understanding, development, and exploitation of molecular electrostatic interaction.