gebhart/patrepeval huggingface dataset:
HOST COMPUTER SYSTEM CAPACITY MANAGEMENT PROCEDURES (1988)

Abstract : The Federal Aviation Administration's Advanced Automation Program Office has recognized the need for monitoring and assessing the National Airspace System's operational performance and for long term planning during the life-cycle of the Host Computer System. The assessment of the operational performance involved the acquisition and analysis of field measurement data, while the long-term capacity planning entails execution of a Host Computer System analytical model using current and project traffic and other system loads. The procedures document defines the activities to be executed in: (1) measuring and monitoring operational performance, (2) measuring projecting system workloads, (3) predicting system performance using an analytical performance model, and (4) analyzing and reporting current and predicted future performance of the Host Computer System.
Broadband low-loss analog fiber-optic link for concurrent detection and downconversion of microwave signals (1995)

Optical fiber is an excellent medium for transmission of microwave-modulated optical signals from a remote antenna to the receiver.1 After reception, these signals are typically downconverted to a lower intermediate frequency (i.f.) to recover the baseband signal. Recently,2 we demonstrated that a pair of external interferometric modulators, cascaded in series and both biased at quadrature, may be used to concurrently receive and downconvert rf signals. Here we adapt this architecture to demonstrate a downconverting fiber-optic link, for remote operation of an antenna, in satellite,1 and wireless communication systems.
METABOLIC RELATIONSHIPS BETWEEN GREEN HYDRA AND ITS SYMBIOTIC ALGAE (1977)

1. Hydra that maintain algal symbionts evidenced three modes of metabolism depending upon the nutritional state of the host and the photoperiodic conditions under which the animals were maintained. Animals either fed or fasted but maintained in the dark exhibited an RQ of 0.725 indicating fat metabolism. When they were fed Artemia nauplii and maintained in the light, green hydra exhibited a mixed metabolism of carbohydrate and fat which gave an RQ of 0.862. Fasting green hydra, when maintained in the light, showed a pronounced carbohydrate metabolism typified by an RQ of 0.970.2. Aposymbiotic hydra, whether fed or fasted, exhibited an RQ of 0.725 indicating a high degree of fat metabolism.3. Symbiotic hydra which were fed and maintained in the light demonstrated a respiration rate of 14.4 µl/day per hydra, which was 2.5 times greater than animals (symbiotic or aposymbiotic) maintained under any other condition of fasting or photoperiod. It is hypothesized that the enhanced respiration observed in these animals is due to the metabolic activities of the symbiotic algae associated with reproduction and development.4. Calculations based on respiratory measurements and indirect calorimetry suggest that hydra consume approximately 0.0320 calories per day and that symbiotic algae may supply up to 69% of the host caloric requirements via the translocation of approximately 5 µg of carbohydrate when the host is fasting and light is provided.
Surface Biomodification of Surgical Meshes Intended for Hernia Repair (2012)

The article presents a method of producing a composite surgical mesh. A synthetic, mac-roporous mesh with mechanical properties similar to that of the abdominal wall and with reduced surface density compared to conventional surgical meshes was made of polypro-pylene (PP) monofilament. The mesh was used as a substrate for a layer of modified bac-terial cellulose (MBC) produced by a microbial synthesis with the use of the Acetobacter xylinum strain. The PP mesh was coated with the MBC layer directly in the process of biosynthesis in liquid culture medium with the addition of chitosan modifier. During the resorption process, under the action of body enzymes, amino sugars are released from the MBC layer, which have the ability to stimulate tissue granulation and accelerate the wound healing process, while preventing formation of scars. Key words: hernia, lightweight surgical mesh, semi-resorbable mesh, modified bacterial cellulose. such implants also histiocytes may accu-mulate and contribute to the rejection of
Design and Performance of Compact Air-Cooled SiC MOSFET Inverters for Low-Power Variable Speed Drive Applications (2014)

Design and experimental results of a scalable and modular air-cooled power inverter using commercial SiC power MOSFETs are reported. Compared to the well-established silicon IGBT power inverter, the new SiC power MOSFET inverter offers 40% more output power and 4% higher efficiency for a 10kW, 20kHz air-cooled design. A detailed design and performance tradeoff is presented from a system-level perspective in terms of cost/kW for SiC inverter for vehicle electrification and power generation applications. The design is based on a simple circuit simulation model developed from measurements made on commercially available packaged discrete SiC power MOSFETs.
Measurement of the Curie temperature distribution in FePt granular magnetic media (2014)

Heat assisted magnetic recording (HAMR) has been recognized as a leading technology to increase the data storage density of hard disk drives. Dispersions in the properties of the grains comprising the magnetic medium can lead to grain-to-grain Curie temperature variations, which drastically affect the jitter in the recorded magnetic transitions and limit the data storage density capabilities in HAMR. Here we present a method to measure the switching probability of an ensemble of exchange-decoupled grains with perpendicular anisotropy subject to nanosecond heating pulses. The short heat exposure time ensures that the grains switch by reaching the Curie temperature rather than through thermal activation. The switching probability can be directly interpreted as representing the Curie temperature distribution. The method is applied to two sets of samples to reveal the sensitivity of the Curie temperature distribution to FePt HAMR media fabrication parameters. This technique is of importance to engineer suitable HAMR media capable of high density magnetic recording and for fundamental studies on sources of magnetic disorder in granular magnetic media.
Experimental evidence for ethylidene-d4 (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExperimental evidence for ethylidene-d4David A. Modarelli and Matthew S. PlatzCite this: J. Am. Chem. Soc. 1993, 115, 2, 470–475Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/ja00055a016https://doi.org/10.1021/ja00055a016research-articleACS PublicationsRequest reuse permissionsArticle Views207Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structural and Biochemical Changes Induced by Pulsed Electric Field Treatments on Cabernet Sauvignon Grape Berry Skins: Impact on Cell Wall Total Tannins and Polysaccharides (2014)

Pulsed electric field (PEF) treatment is an emerging technology that is arousing increasing interest in vinification processes for its ability to enhance polyphenol extraction performance. The aim of this study was to investigate the effects of PEF treatment on grape skin histocytological structures and on the organization of skin cell wall polysaccharides and tannins, which, until now, have been little investigated. This study relates to the effects of two PEF treatments on harvested Cabernet Sauvignon berries: PEF1 (medium strength (4 kV/cm); short duration (1 ms)) and PEF2 (low intensity (0.7 kV/cm); longer duration (200 ms)). Histocytological observations and the study of levels of polysaccharidic fractions and total amounts of tannins allowed differentiation between the two treatments. Whereas PEF1 had little effect on the polyphenol structure and pectic fraction, PEF2 profoundly modified the organization of skin cell walls. Depending on the PEF parameters, cell wall structure was differently affected, providing variable performance in terms of polyphenol extraction and wine quality.
Genetic Characterization of Intermixed Walleye Stocks in Claytor Lake and the Upper New River, Virginia (1999)

Historically, the New River may have contained a genetically unique, river-spawning population of walleye (Stizostedion vitreum). Additionally, a number of genetically different walleye stocks have been stocked in Claytor Lake, Virginia. The increasing importance of the walleye fishery led to interest in clarifying key unknowns regarding the biology of the New River walleye stock. A radio telemetry study and genetic evaluation of present-day stocks led to identification of three spawning areas and the characterization of the genetic stock structure of walleye in Claytor Lake and the upper New River. Using radio telemetry to track movements of walleye, I determined that two resident walleye populations co-exist: one within Claytor Lake and the other in the New River above the lake. These populations establish spatially disjunct home ranges, remaining spatially separated throughout most of the year. Although there is no blockage to movement or migration, walleye within Claytor Lake generally spawn at Allisonia, while walleye within the upper New River spawn at Buck Dam. Some walleye from both populations spawn in other areas, such as Fosters Falls. Using allozymes, microsatellite DNA, and mitochondrial DNA marker techniques to examine population structure of walleye, I determined that the walleye within Claytor Lake are a panmictic population. This is the result of years of stocking walleye from different genetic stocks and interbreeding among individuals. The genetic structure of walleye from the New River also shows the presence of more than one genetic stock. Within the New River population, there exists a genetic stock of walleye that is characterized by three mitochondrial DNA haplotypes (43, 44, and 45) that previously have not been seen. This may be indicative of a unique walleye stock that is native to the New River and which has remained spatially or temporally segregated by spawning habits. The co-existence of two different walleye populations in the Claytor Lake / upper New River system justifies different management strategies. I recommend that management of the walleye population in Claytor Lake focus on increasing the exploitation of this non-indigenous stock. Management of the upper New River walleye population should focus on conservation of the unique native stock through supportive breeding and/or strict harvest regulations.
Atmospheric pressure laser desorption/ionization on porous silicon (2002)

A recently developed commercial atmospheric pressure matrix-assisted laser desorption/ionization (AP-MALDI) source (MassTech, Inc.) was modified to adopt commercially available DIOS plates (Mass Consortium Corp.) for the studies of laser desorption from the surface of porous silicon under atmospheric pressure conditions. The feasibility of atmospheric pressure laser desorption/ionization from the surface of porous silicon (AP-DIOS) was demonstrated. The advantages of this new AP-DIOS technique include reasonably good sensitivity (subpicomole range for standard peptide mixtures), simplicity of sample preparation, uniformity of target spots and the absence of matrix peaks in the spectra. The AP-DIOS source was interfaced with a commercial ion trap (LCQ Classic, Thermo Finnigan) which additionally provides a unique MS(n) capability. The AP-DIOS spectrum of 250 fmol of unseparated tryptic digest of bovine serum albumin (BSA) was compared with that of AP-MALDI for the same compound. AP-DIOS offers significantly better coverage for the digest components in the mass range 200-1000 Da. The combined data of both techniques enabled us to nearly double the number of matched peaks in BSA digest analysis compared with AP-DIOS or AP-MALDI analysis separately.
Dynamics of Cable Harnesses on Large Precision Structures. (2016)

Abstract not provided.
Thermodynamic characteristics of poly(cyclohexylethylene‐b‐ethylene‐co‐ethylethylene) block copolymers (2010)

Abstract A series of poly(cyclohexylethylene‐ b ‐ethylene‐ co‐ ethylethylene) (C‐E/E E ) diblock copolymers containing approximately 50% by volume glassy C blocks and varying fraction ( x ) of E E repeat units, 0.07 ≤ x ≤ 0.90, was synthesized by anionic polymerization and catalytic hydrogenation. The effects of ethyl branch content on the melt state segment–segment (χ) interaction parameter and soft (E/E E ) block crystallinity were studied. The percent crystallinity ranged from approximately 30% at x = 0.07 to 0% at about x ≥ 0.30, while the melting temperature changed from 101 °C at x = 0.07 to 44 °C at x = 0.28. Dynamic mechanical spectroscopy was employed to determine the order–disorder transition (ODT) temperatures, from which χ was calculated assuming the mean‐field prediction (χ N n ) ODT = 10.5. Previously published results for the temperature dependent binary interaction parameters for C‐E ( x = 0.07), C‐E E ( x = 0.90), and E‐E E ( x = 0.07 and x = 0.90) fail to account for the quantitative x dependence of χ, based on a simple binary interaction model. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48: 566–574, 2010
Intracellular single chain Fv antibody inhibits Ras activity in T‐cell antigen receptor stimulated Jurkat cells (1994)

A mammalian expression vector directing the synthesis of a cytoplasmic single chain Fv version of the Y13-259 anti-Ras antibody was constructed and co-transfected into the human lymphoid cell line Jurkat together with a reporter construct containing the bacterial gene for chloramphenicol acetyl transferase under the transcriptional control of several copies of the binding site for the transcription factor NF-AT. The Ras specific antibody interferes with NF-AT activation upon direct activation of the T-cell antigen receptor, whereas activation by direct protein kinase C stimulation is less sensitive to the anti-Ras antibody. Furthermore, the observed inhibition is dependent on the ratio of antibody to reporter plasmid utilized in the transfection experiments.
FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome (2020)

Fragile X Syndrome results from a loss of Fragile X Mental Retardation Protein (FMRP). We now show that FMRP is a member of a Cav3-Kv4 ion channel complex that is known to regulate A-type potassium current in cerebellar granule cells to produce mossy fiber LTP. Mossy fiber LTP is absent in Fmr1 knockout (KO) mice but is restored by FMRP(1-297)-tat peptide. This peptide further rapidly permeates the blood-brain barrier to enter cells across the cerebellar-cortical axis that restores the balance of protein translation for at least 24 h and transiently reduces elevated levels of activity of adult Fmr1 KO mice in the Open Field Test. These data reveal that FMRP(1-297)-tat can improve function from the levels of protein translation to synaptic efficacy and behaviour in a model of Fragile X syndrome, identifying a potential therapeutic strategy for this genetic disorder.
Non-invasive delivery of small interfering rubonucleic acid for reduction of Huntingtin expression in the brain is achieved using focused ultrasound to disrupt the blood-brain barrier (2013)

Huntington's disease (HD) is caused by a mutation in the Huntingtin (Htt) gene which leads to neuronal dysfunction and cell death. Silencing of the Htt gene can halt or reverse the progression of the disease suggesting that RNA interference is an effective strategy for disease treatment. However, siRNA does not cross the blood-brain barrier (BBB) and therefore delivery to the brain is limited. Here, we demonstrate that focused ultrasound (FUS), combined with intravascular microbubble contrast agent, can locally and transiently disrupt the BBB and deliver siRNA into the brain. We disrupted the BBB in the right striatum of adult rats and delivered siRNA intravenously. 48 hrs following treatment, the right (treated) and left (control) striatum were dissected and analyzed for Htt mRNA levels. We observed a significant reduction in Htt expression in the right, treated striatum, in a dose dependent manner. Furthermore, reduction of Htt was positively correlated with the extent of BBB disruption. This study demonstrates that siRNA mediated reduction of Htt is feasible without the surgical intervention previously required for direct delivery to the brain. Non-invasive delivery of siRNA through the BBB would be a significant advantage for translating RNA interference therapy to HD patients.
QUANTITATIVE STUDY OP DOCTOR-PATIENT COMMUNICATION (1969)

Journal Article QUANTITATIVE STUDY OP DOCTOR-PATIENT COMMUNICATION Get access C. R. B. JOYCE, C. R. B. JOYCE 1The Department of Pharmacology Search for other works by this author on: Oxford Academic PubMed Google Scholar GRACE CAPLE, GRACE CAPLE The Department of Therapeutics Search for other works by this author on: Oxford Academic PubMed Google Scholar MICHAEL MASON, MICHAEL MASON The London Hospital Medical College Search for other works by this author on: Oxford Academic PubMed Google Scholar EVELYN REYNOLDS, EVELYN REYNOLDS The Department of Physical Medicine Search for other works by this author on: Oxford Academic PubMed Google Scholar J. A. MATHEWS J. A. MATHEWS The Department of Rheumatology, The London Hospital Search for other works by this author on: Oxford Academic PubMed Google Scholar QJM: An International Journal of Medicine, Volume 38, Issue 2, April 1969, Pages 183–194, https://doi.org/10.1093/oxfordjournals.qjmed.a067175 Published: 01 April 1969 Article history Received: 28 September 1968 Published: 01 April 1969
Facilitating an integrated Silicon Photonics platform (2015)

This paper summarises our recent work on an integrated silicon modulator and driver to achieve up to 30Gb/s, with an extinction ratio in excess of 4dB, a fabrication tolerant multiplexer, and a device to facilitate wafer scale testing.
Design of a freeform, dual fields-of-view, dual focal lengths, off-axis three-mirror imaging system with a point-by-point construction-iteration process (2016)

In this Letter, we propose a novel configuration and design method of freeform, dual fields-of-view (FOVs), dual focal lengths, off-axis three-mirror zoom imaging systems. The switch of the two zooms is achieved by rotating a single mirror element. The design of a freeform, dual focal lengths zoom system is realized by a point-by-point design approach for the first time to our knowledge. This method enables the direct design of freeform surfaces from initial planes using given system specifications and configuration, and the designed system can be taken as a good starting point for further optimization. A freeform, dual FOVs, dual focal lengths, off-axis three-mirror zoom system is demonstrated. The F-numbers of the two zooms are 2 and 2.4. The dual FOVs are 3°×3° and 2.5°×2.5°. After final optimization, both of the zooms achieve high performances.
Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction (2016)

Neuregulins are important growth factors involved in cardiac development and response to stress. Certain isoforms and fragments of neuregulin have been found to be cardioprotective. The effects of a full-length neuregulin-1β isoform, glial growth factor 2 (GGF2; USAN/INN; also called cimaglermin) were investigated in vitro. Various dosing regimens were then evaluated for their effects on left ventricular (LV) function in rats with surgically-induced myocardial infarction. In vitro, GGF2 bound with high affinity to erythroblastic leukemia viral oncogene (ErbB) 4 receptors, potently promoted Akt phosphorylation, as well as reduced cell death following doxorubicin exposure in HL1 cells. Daily GGF2 treatment beginning 7-14 days after left anterior descending coronary artery ligation produced improvements in LV ejection fraction and other measures of LV function and morphology. The improvements in LV function (e.g. 10% point increase in absolute LV ejection fraction) with GGF2 were dose-dependent. LV performance was substantially improved when GGF2 treatment was delivered infrequently, despite a serum half-life of less than 2h and could be maintained for more than 10 months with treatment once weekly or once every 2 weeks. These studies confirm previous findings that GGF2 may improve contractile performance in the failing rat heart and that infrequent exposure to GGF2 may improve LV function and impact remodeling in the failing myocardium. GGF2 is now being developed for the treatment of heart failure in humans.
Infectious reactivation of cytomegalovirus explaining age- and sex-specific patterns of seroprevalence (2017)

Human cytomegalovirus (CMV) is a herpes virus with poorly understood transmission dynamics. Person-to-person transmission is thought to occur primarily through transfer of saliva or urine, but no quantitative estimates are available for the contribution of different infection routes. Using data from a large population-based serological study (n = 5,179), we provide quantitative estimates of key epidemiological parameters, including the transmissibility of primary infection, reactivation, and re-infection. Mixture models are fitted to age- and sex-specific antibody response data from the Netherlands, showing that the data can be described by a model with three distributions of antibody measurements, i.e. uninfected, infected, and infected with increased antibody concentration. Estimates of seroprevalence increase gradually with age, such that at 80 years 73% (95%CrI: 64%-78%) of females and 62% (95%CrI: 55%-68%) of males are infected, while 57% (95%CrI: 47%-67%) of females and 37% (95%CrI: 28%-46%) of males have increased antibody concentration. Merging the statistical analyses with transmission models, we find that models with infectious reactivation (i.e. reactivation that can lead to the virus being transmitted to a novel host) fit the data significantly better than models without infectious reactivation. Estimated reactivation rates increase from low values in children to 2%-4% per year in women older than 50 years. The results advance a hypothesis in which transmission from adults after infectious reactivation is a key driver of transmission. We discuss the implications for control strategies aimed at reducing CMV infection in vulnerable groups.
Biological effect of microengineered grooved stents on strut healing: a randomised OCT-based comparative study in humans (2017)

BMS, OCT, clinical trials.
Measurements and simulation of radio frequency impulsive noise in hospitals and clinics (2002)

Electrical and mechanical equipment can be a major source of interference to indoor wireless systems. A receiver system was developed to measure the time-varying nature of such "impulsive noise" in the 450 MHz band, and extensive measurements were made in hospitals and clinics across the United States. Empirical distributions were extracted for the amplitude, inter-arrival time, and duration of the observed noise pulses. The software propagation simulation tool SIRCIM Plus was developed to include the simulation of impulsive noise in indoor environments, based on the measurements reported here.