gebhart/patrepeval huggingface dataset:
Photoswitchable quantum dots by controlling the photoinduced electron transfers (2012)

We report photoluminescence (PL) modulation of quantum dots (QDs) by photoinduced electron transfers from acridine-1,8-dione derivative surface ligands. Reversible PL switching upon many repeated cycles was demonstrated, as alternating on and off of the UV excitation for the surface ligand has successfully resulted in the QD PL modulation.
A Diesel Lean Nox Trap Model for Control Strategy Verification (2004)

&lt;div class="htmlview paragraph"&gt;Lean NOx traps are considered as a possible means to reduce diesel powertrain tail pipe NOx emissions to future stringent limits. Several publications have proposed models for lean NOx traps [&lt;span class="xref"&gt;1&lt;/span&gt;, &lt;span class="xref"&gt;2&lt;/span&gt;, &lt;span class="xref"&gt;3&lt;/span&gt; and &lt;span class="xref"&gt;4&lt;/span&gt;]. This paper focuses on a lean NOx trap model that can be used for the verification of control strategies before these strategies are implemented in target microprocessors. Strategy verification in a simulation environment is a crucial tool for reducing control strategy development and implementation time.&lt;/div&gt;
Application of Fast Light to Enhancing the Bandwidth-Sensitivity Product of a Gravitational Wave Detector (2007)

A Fast-Light based White Light Cavity can be used to enhance the bandwidth-sensitivity product for gravitational-wave detection. Here, we demonstrate such a system in a meter-long ring-cavity using bi-frequency Raman gain in the intra-cavity medium.
Synthesis of Tungsten Oxo Alkylidene Biphenolate Complexes and Ring-Opening Metathesis Polymerization of Norbornenes and Norbornadienes (2019)

We have synthesized and characterized tungsten oxo alkylidene biphenolate complexes with the formulas W(O)(CHR)(rac-biphenolate)(PPhMe2) and (R,S)-[W(μ-O)(CHR)(biphenolate)]2 (R = CMe2Ph; biphenolate = L1 or L2 in the text). They behave as initiators for the stereoselective (cis,isotactic) polymerization of 2,3-dicarbomethoxy-5-norbornadiene and eight enantiomerically pure 5-substituted norbornenes with a cis,isotactic precision of 95–98% in most cases. The active initiators are 14e W(O)(CHR)(biphenolate) complexes, which are formed through either dissociation of PPhMe2 from the phosphine adducts or scission of the heterochiral dimer. Addition of B(C6F5)3 (one per W) to (R,S)-[W(μ-O)(CHR)(L1)]2 led to formation of what we propose to be monomeric W[OB(C6F5)3](CHR)(L1) in equilibrium with B(C6F5)3 and (R,S)-[W(μ-O)(CHR)(L1)]2. This mixture decomposed over a period of 1–2 h, was much slower to initiate polymerization than (R,S)-[W(μ-O)(CHR)(L1)]2, and was much less stereoselective. Polymerization of five of the monomers with the imido alkyidene initiator, W(N-2,6-Me2C6H3)(CHCMe2Ph)(rac-L1), gave virtually identical results compared to the results obtained with oxo complexes.
Between all and nothing - versatile aborts in hardware transactional memory (2013)

Hardware Transactional Memory (HTM) implementations are becoming available in commercial, off-the-shelf components. While generally comparable, some implementations deviate from the strict all-or-nothing property of pure Transactional Memory. We analyse these deviations and find that with small modifications, they can be used to accelerate and simplify both transactional and non-transactional programming constructs. At the heart of our extensions we enable access to the transaction's full register state in the abort handler in an existing HTM without extending the architectural register state. Access to the full register state enables applications in both transactional and non-transactional parallel programming: hybrid transactional memory; transactional escape actions; transactional suspend/resume; and alert-on-update.
SR 48968 selectively prevents faecal excretion following activation of tachykinin NK2 receptors in rats (1994)

We tested the ability of SR 48968, (S)-N-methyl-N(4-(4-acetylamino-4-phenylpiperidino)-2-(3,4-dichloropheny l)butyl ) benzamide, a non-peptide antagonist highly selective for tachykinin NK2 receptors, to prevent defecation induced in rats by several agents. The tachykinin agonists substance P, [MePhe7]neurokinin B and [beta-Ala8]neurokinin A (4-10) all promoted defecation and increased faecal water content, the last compound being over ten times more potent than the other two (intraperitoneal dose inducing the excretion of 1 g faeces dry weight = 6.7 micrograms kg-1). SR 48968 given either orally (p.o.) or subcutaneously (s.c.) was similarly potent in dose-dependently inhibiting faecal output stimulated by the selective NK2-agonist [beta-Ala8]neurokinin A (4-10) (doses causing 50% inhibition 0.4 microgram kg-1, p.o. and 0.3 microgram kg-1, s.c.). This inhibition was long-lasting (more than 18 h after 1 microgram kg-1 SR 48968 either s.c. or p.o.). At the higher doses tested, SR 48968 also significantly prevented the increase in faecal water content produced by [beta-Ala8]neurokinin A (4-10). In rats treated with SR 48968, stimulation of faecal output by the alpha 2-adrenergic antagonist idazoxan and by salmonella endotoxin (LPS), but not by the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin, 5-HT, carbachol or platelet-activating factor, was partially prevented. The present results suggest that activation of intestinal NK2 receptors, either directly by the selective agonist [beta-Ala8]neurokinin A (4-10) or indirectly through the release of endogenous neurokinin A (by idazoxan or LPS), promotes defecation, presumably as a consequence of increased gut motility or secretion, or both. SR 48968 should therefore be useful for studying the role of neurokinin A-dependent mechanisms in health and disease, including those of the gastrointestinal system, and possibly for developing new therapeutic agents.
Application of near-infrared spectroscopy in human elite freedivers while deep diving on a single breath hold (2021)

Near-infrared spectroscopy was used to observe the cerebral hemodynamic response of freedivers during single breath-hold training dives. We observed variability in hemodynamic progression, and heartbeat shape changes with diving depth.
The cytolytic T lymphocyte response to trinitrophenyl-modified syngeneic cells. I. Evidence for antigen-specific helper T cells. (1979)

Mice were primed subcutaneously with trinitrophenyl (TNP)-modified syngeneic spleen cells. Seven days later, spleen cells from these in vivo primed mice, or spleen cells from naive mice, were co-cultured with TNP-modified syngeneic cells. Spleen cells from the in vivo primed mice demonstrated augmented cytolytic T lymphocyte (CTL) activity. The spleens of these in vivo primed mice contained a population of radioresistant, antigen-specific, helper T cells. Specifically, spleen cells from these mice, after x-irradiation, were able to augment the in vitro CTL response of normal spleen cells to TNP-modified syngeneic cells.
Leakage Prevention and Real-Time Internal Detection in Pipelines Using a Built-In Wireless Information and Communication Network (2020)

Summary A series of recent pipeline leakage incidents created severe societal concerns to a point of impeding, or even completely preventing, building new pipelines in North America. Various systems have been proposed to identify and locate leakages. However, despite the fact that pipelines remain the safest means of oil and gas transportation, incidents still persist and pipeline acceptance from the public has become compromised. In order to address the need for early leakage detection, while providing comprehensive leakage prevention, a novel pipeline system is proposed. This concept builds on the already existing pipe-in-pipe design by segmenting the pipeline system with segmentation rings and embedding a linear wireless network in the annular airgap between the two pipe layers. Presence of fluid in the case of a leakage into the interpipe space causes degradation of the wireless network to a point of interrupting the communication in a particular pipeline segment well before any external leak occurs. Thus, the internal leak is detected in real time by an external central unit connected to the linear wireless network, as demonstrated with a 6 ft 8 in. experimental pipeline setup.
Combined light and electron scattering for exploring hydrogen in thin metallic films (2010)

We present a method, combining optical transmission with electrical resistance, to study the hydrogen uptake in thin transition metal films. The change in optical transmission is used to determine the hydrogen concentration, while the change in resistance serves as an indicator for the ordering of hydrogen. We identify phase boundaries and regions of high and low orders as well as changes in the ordering temperature. As a demonstration of this approach we compare the hydrogen uptake of 50 and 10 nm single-crystal vanadium films. The ordered phase is found to be extended to higher temperatures in the thinner sample.
Engineering therapeutic bispecific antibodies using CrossMab technology (2018)

Bispecific antibodies have recently gained major interest as they allow novel mechanisms-of-action and/or therapeutic applications that cannot be achieved using conventional IgG-based antibodies. A major issue in engineering IgG-based bispecific antibodies has been to enable the correct association of heavy and light chains resulting in correct assembly of the desired bispecific antibody in sufficient yield. Various approaches have been described during recent years to tackle this challenge. We have developed the so-called CrossMab technology that enforces correct light chain association based on the domain crossover of immunoglobulin domains in the Fab region of the bispecific antibody. This versatile technology allows the generation of different bispecific antibody formats including asymmetric heterodimeric monovalent 1 + 1 bispecific antibodies and asymmetric heterodimeric bispecific antibodies with 2 + 1 valency in combination with approaches enabling Fc-hetermodimerization like knob-into-hole technology as well as the generation of tetravalent symmetric bispecific antibodies with 2 + 2 valency, also known as Tandem-Fab based IgG antibodies, using processes suitable for the large scale production of therapeutic bispecific antibodies. Notably, as of now, at least eight different bispecific antibodies using CrossMab technology entered clinical development, and additional CrossMabs are in late preclinical development. This review provides a summary of the status and progress with the engineering and generation of CrossMab technology based bispecific antibodies as well as their therapeutic application.
A prostate-specific membrane antigen (PSMA)-targeted prodrug with a favorable in vivo toxicity profile (2021)

Prostate-specific membrane antigen (PSMA) is a promising target for the treatment of advanced prostate cancer (PC) and various solid tumors. Although PSMA-targeted radiopharmaceutical therapy (RPT) has enabled significant imaging and prostate-specific antigen (PSA) responses, accumulating clinical data are beginning to reveal certain limitations, including a subgroup of non-responders, relapse, radiation-induced toxicity, and the need for specialized facilities for its administration. To date non-radioactive attempts to leverage PSMA to treat PC with antibodies, nanomedicines or cell-based therapies have met with modest success. We developed a non-radioactive prodrug, SBPD-1, composed of a small-molecule PSMA-targeting moiety, a cancer-selective cleavable linker, and the microtubule inhibitor monomethyl auristatin E (MMAE). SBPD-1 demonstrated high binding affinity to PSMA (K<sub>i</sub> = 8.84 nM) and selective cytotoxicity to PSMA-expressing PC cell lines (IC<sub>50</sub> = 3.90 nM). SBPD-1 demonstrated a significant survival benefit in two murine models of human PC relative to controls. The highest dose tested did not induce toxicity in immunocompetent mice. The high specific targeting ability of SBPD-1 to PSMA-expressing tumors and its favorable toxicity profile warrant its further development.
AUGMENTATION OF RESEARCH AND ANALYSIS CAPABILITIES FOR TIMELY SUPPORT OF AUTOMOTIVE FUEL ECONOMY ACTIVITIES (1981)

A series of studies were conducted in support of the Office of Research and Development of the NHTSA in areas of automotive design and technology that could affect fuel economy. Nine such studies were carried out and included assessments of spark ignition engine; fuel economy improvement potential; potential of changes in rolling resistance, aerodynamic drag, accessory load and lubricants. Other studies included a study of the potential of alternate engines, a compilation of literature, and a preliminary assessment of diesel particulates. In addition to conducting studies based on a literature review and analysis, there were two hardware studies conducted in the form of teardown studies of selected passenger car (Ford Fairmont) and light truck (Chevy Luv) models.
Correction: Common Infectious Agents and Monoclonal B-Cell Lymphocytosis: A Cross-Sectional Epidemiological Study among Healthy Adults (2013)

Background: Risk factors associated with monoclonal B-cell lymphocytosis (MBL), a potential precursor of chronic lymphocytic leukaemia (CLL), remain unknown.
Ibrutinib Plus Rituximab Versus Placebo Plus Rituximab for Waldenström's Macroglobulinemia: Final Analysis From the Randomized Phase III iNNOVATE Study (2021)

In the final analysis of iNNOVATE with a median follow-up of 50 months, ibrutinib-rituximab showed ongoing superiority across clinical outcomes in patients with WM regardless of <i>MYD88</i> or <i>CXCR4</i> mutation status, prior treatment, and key patient characteristics.
Development and Characterization of a High Performance Thin-Film Planar SOFC Stack (2005)

A planar solid oxide fuel cell (SOFC) was fabricated using a tape-cast Ni/yttria-stabilized zirconia (YSZ) anode support, a YSZ thin-film electrolyte, and a composite cathode of YSZ and (LSM). Using pure hydrogen as the fuel gas, a three-cell stack with a cross-flow design and external manifolds produced peak power densities of 0.85 and at 800 and 700°C, respectively. Using wet methane as the fuel gas, the stack produced a peak power density of at 700°C. Individual cells in the stack showed identical current-voltage characteristics. Stack lifetime was limited because of degradation of the cells from oxidation products coming from the metallic interconnect used. © 2004 The Electrochemical Society. All rights reserved.
Supplementary Data 7 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer (2023)

&lt;p&gt;Body weights for LNCaP F877L xenograft model in castrated male SHO mice&lt;/p&gt;
Scalable application layer multicast (2002)

We describe a new scalable application-layer multicast protocol, specifically designed for low-bandwidth, data streaming applications with large receiver sets. Our scheme is based upon a hierarchical clustering of the application-layer multicast peers and can support a number of different data delivery trees with desirable properties.We present extensive simulations of both our protocol and the Narada application-layer multicast protocol over Internet-like topologies. Our results show that for groups of size 32 or more, our protocol has lower link stress (by about 25%), improved or similar end-to-end latencies and similar failure recovery properties. More importantly, it is able to achieve these results by using orders of magnitude lower control traffic.Finally, we present results from our wide-area testbed in which we experimented with 32-100 member groups distributed over 8 different sites. In our experiments, average group members established and maintained low-latency paths and incurred a maximum packet loss rate of less than 1% as members randomly joined and left the multicast group. The average control overhead during our experiments was less than 1 Kbps for groups of size 100.
Sketching as a Tool for Understanding and Accelerating Self-attention for Long Sequences (2021)

Transformer-based models are not efficient in processing long sequences due to the quadratic space and time complexity of the self-attention modules. To address this limitation, Linformer and Informer are proposed to reduce the quadratic complexity to linear (modulo logarithmic factors) via low-dimensional projection and row selection respectively. These two models are intrinsically connected, and to understand their connection, we introduce a theoretical framework of matrix sketching. Based on the theoretical analysis, we propose Skeinformer to accelerate self-attention and further improve the accuracy of matrix approximation to self-attention with three carefully designed components: column sampling, adaptive row normalization and pilot sampling reutilization. Experiments on the Long Range Arena (LRA) benchmark demonstrate that our methods outperform alternatives with a consistently smaller time/space footprint.
Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of linear tricyclic carboxamides (1988)

Structure-antitumor activity relationships are reported for a number of different examples (acridine, phenazine, anthracene, acridone, xanthenone, thioxanthenone, anthraquinone, pyridoquinazoline, dibenzodioxin, thianthrene, phenothiazine, phenoxazine, dibenzofuran, carbazole, and pyridoindole) of the general class of N-[2-(dimethylamino)ethyl] linear tricyclic carboxamides. Only the compounds containing coplanar chromophores intercalated DNA. There is an absolute requirement for an oxygen or aromatic nitrogen (possibly as hydrogen-bond acceptors) peri to the carboxamide, together with a planar ring geometry for biological activity. In addition to further delineating the nature of the pharmacophore for this class of compounds, the work has also identified dibenzo[1,4]dioxin as a novel DNA-intercalating chromophore with in vivo antitumor activity.
ChemInform Abstract: Isotope Effect on Physical Properties of BEDT‐TTF Based Organic Superconductors (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effect of Indium Doping of γ-Alumina on the Stabilization of PtSn Alloyed Clusters Prepared by Surface Organostannic Chemistry (2012)

The control of the atomic-scale properties of highly dispersed multimetallic particles represents a challenging question for the optimal use of metallic active centers in nanoscience. In particular, improving the formation of PtxSn alloyed clusters on γ-alumina of a size close to 1 nm with a high Sn0/Pt ratio represents a crucial step toward more selective heterogeneous catalysts. For that purpose, bimetallic SnPt-based and trimetallic SnPtIn-based catalysts were prepared by surface organostannic chemistry on monometallic Pt and bimetallic PtIn-based catalysts. These systems were characterized by a multitechnique approach combining CO chemisorption, temperature programmed reduction, scanning transmission electron microscopy, Mössbauer spectroscopy, and X-ray absorption spectroscopy. The nature of the PtSn phase in trimetallic SnPtIn-based catalysts is found to strongly depend on the way indium is initially introduced in the parent catalyst, by either wet impregnation or coprecipitation with aluminum precursor. The key role of In3+ species on the formation of PtSn alloyed clusters is revealed. By using density functional theory calculations, we give a rational interpretation of the experimental results and provide an atomic scale description of PtxSny/γ-Al2O3 systems, with or without In3+ on the alumina surface. The formation of In–Pt, In–Sn, and O–Sn bonds is indeed favored when In3+ is present in the support. This work proposes an original approach for stabilizing PtxSn alloyed clusters with an elevated Sn0/Pt ratio and highly dispersed on γ-alumina using indium as “third element” introduced as In3+ on the support.
Optomechanical Design with Wide Field of View Fiber-Coupled Image Systems (2014)

Fiber-coupled imaging provides new opportunities for optomechanical system design and layout, and also new challenges when achieving high pixel counts and wide fields of view using multiple sensors in monocentric imaging systems with integrated focus.
A hybrid error concealment method based on H.264 standard (2006)

A hybrid error concealment method for H.264 compressed video is presented in this paper. The method can adequately exploit the spatial and temporal relativities of video sequence to adaptively select the spatial concealment or temporal concealment according to the boundary match criterion. In order to further improve the reconstructed video quality, a maximum a posteriori (MAP) estimator is then employed to post-dispose the concealed areas. The experimental results show that the proposed method can achieve excellent concealment performance with remarkably improved subjective quality of the reconstructed video
FreeCast: Graceful Free-Viewpoint Video Delivery (2018)

Wireless multi-view plus depth (MVD) video streaming enables free viewpoint video playback on wireless devices, where a viewer can freely synthesize any preferred virtual viewpoint from the received MVD frames. Existing schemes of wireless MVD streaming use digital-based compression to achieve better coding efficiency. However, the digital-based schemes have an issue called the cliff effect, where the video quality is a step function in terms of wireless channel quality. In addition, parameter optimization to assign quantization levels and transmission power across MVD frames are cumbersome. To realize high-quality wireless MVD video streaming, we propose a novel graceful video delivery scheme, called FreeCast. FreeCast directly transmits linear-transformed signals based on 5-D discrete cosine transform, without digital quantization and entropy coding operations. In addition, we exploit a fitting function based on a multidimensional Gaussian Markov random field model for overhead reduction to mitigate rate and power loss due to large overhead. The proposed FreeCast achieves graceful video quality with the improvement of wireless channel quality under a low overhead requirement. In addition, the parameter optimization to achieve highest video quality can be simplified by only controlling a transmission power assignment. Performance results with several test MVD video sequences show that FreeCast yields better video quality in band-limited environments by significantly decreasing the amount of overhead. For instance, structural similarity (SSIM) performance of FreeCast is approximately 0.127 higher than the existing graceful video delivery schemes across wireless channel quality, i.e., signal-to-noise ratio, of 0-25 dB at a transmission symbol rate of 37.5 Msymbols/s.