gebhart/patrepeval huggingface dataset:
Therapeutic Angiogenesis Induced by Hepatocyte Growth Factor : Potential Gene Therapy for Ischemic diseases (2000)

Recent progress in molecular biology has led to the development of gene therapy as a new strategy to treat a variety of cardiovascular diseases. Targeted diseases range from single gene deficiency diseases to more complex diseases in adults such as restenosis after angioplasty. One obvious major target in the field of gene therapy is ischemic diseases such as myocardial infarction, angina and peripheral arterial diseases (i.e. ASO (arteriosclerosis obliterans)). In a large proportion of such patients, the anatomical extent and the distribution of arterial occlusive disease make the patients unsuitable for operative or percutaneous revascularization. Thus, the disease frequently follows an inexorable downhill course. Of importance, there is no optimal medical therapy for severe ischemic hearts and critical ischemic limbs. Therefore, novel therapies are required to treat these patients. Recently, the efficacy of therapeutic angiogenesis using VEGF (vascular endothelial growth factor) gene transfer has been reported in human patients with critical limb ischemia and myocardial ischemia. Thus, the strategy for therapeutic angiogenesis using angiogenic growth factors should be considered for the treatment of patients with critical limb ischemia or myocardial infarction. The endothelial cell specificity of VEGF has been considered to be an important advantage for therapeutic angiogenesis, as endothelial cells represent the critical cellular element responsible for new vessel formation. Indeed, human gene therapy for ASO and angina has already begun in the USA, with surprising and beneficial effects. We have focused on hepatocyte growth factor (HGF), which is a mesenchyme-derived pleiotropic factor that regulates cell growth, cell motility, and morphogenesis in various types of cells. Recently, HGF is also considered to be a powertul growth tactor for endothelial cells. In this review, we described the potential gene therapy for ischemic diseases using HGF.
Spin-on n-Type Silicon Films Using Phosphorous-doped Polysilanes (2007)

We have developed a liquid precursor that can be used in a solution process to form n-type doped silicon films. This precursor is based on phosphorus-doped hydrogenated polysilane synthesized by photo-copolymerizing cyclopentasilane and white phosphorus. By spin-coating this precursor, we have prepared n-type amorphous silicon films and polycrystalline silicon films with resistivities of 6.5–27 Ω·cm and 2.0–10 mΩ·cm, respectively.
The Ribonuclease-Activity of Barley (1961)

1. Harley-ribonuclease has been partially purified from dried rootlets, obtained as a by product from the malt industry.2. By chromatography on a hydroxyapatite column the enzyme preparation can be completely freed from the non-specific phosphodiesterase and to a large extend from the phosphomonoesterase.3. Soule general characteristics of barley-ribonuclease are described. The activity is optimal at pH 6.1. Cu++ and Zn++ are potent inhibitors. Free sulfhydryl-groups are not essential for activity. Neutral solutions can be stored for years, and are relatively thermostable. An enzyme solution at pH 1 resists 1 min. heating at 100° C.
Surface-Expressed Mig Protein ProtectsStreptococcus dysgalactiaeagainst Phagocytosis by Bovine Neutrophils (2001)

The mig gene of Streptococcus dysgalactiae, a major bovine mastitis pathogen, encodes two plasma protein-binding receptors, alpha2-macroglobulin (alpha2-M) and immunoglobulin G (IgG). In this study, the mig gene from one S. dysgalactiae isolate was cloned and expressed in Escherichia coli. The IgG receptor region encoded by mig was conserved in 16 S. dysgalactiae strains. An isogenic mig mutant was constructed by allele replacement mutagenesis of the wild-type gene in S. dysgalactiae. The IgG-binding activity was lost in the mig mutant strain, whereas the alpha2-M receptor activity was still expressed but was detected only in the culture supernatant. In flow cytometry phagocytosis and bacterial-colony-counting bactericidal assays, the wild-type strain was found to be significantly more resistant to phagocytosis and killing by bovine neutrophils (PMNs) than the mig mutant strain when bacteria were preincubated with bovine serum. We therefore speculate that the Mig protein of S. dysgalactiae plays a role in virulence of the bacteria by binding to the plasma protein alpha2-M or IgG and thus preventing phagocytosis by bovine PMNs.
Efficient segmentation for multi-frame iris acquisition on smartphones (2016)

An iris segmentation technique, optimized for relatively low quality images acquired with smartphone visible-near infrared cameras is presented. The proposed technique is based on 1-D processing of the eye image and does not employ geometrical shape fitting. Hence, it is computationally efficient and enables multiple iris images to be extracted sequentially at native frame rates.
Unique Superantigen Activity of Staphylococcal Exfoliative Toxins (1999)

Certain strains of Staphylococcus aureus express one or both of two related, but immunologically distinct, exfoliative toxins (ETA and ETB). These toxins induce the symptoms associated with staphylococcal scalded skin syndrome. Both ETs have been shown to stimulate T cell proliferation. Recently, it was reported that ETA is a superantigen that stimulates T cells bearing human Vbeta2 or several murine Vbetas. However, other investigators have proposed that the superantigenicity reported for ETA resulted from contaminants in commercial preparations. This present study addresses those conflicting reports by assessing the biological and immunologic activities of highly purified rETs. ETA and ETB required APCs to induce selective polyclonal expansion of several human Vbetas (huVbetas), although, neither toxin expanded huVbeta2. ETB induced expansion of murine T cells bearing Vbetas 7 and 8, those that have the highest homology to the huVbetas expanded by ETA and ETB. Although flow cytometry of ETB-stimulated T cells matched PCR results, stimulation by ETA reduced percentages of T cells positive for several huVbetas that had been shown to have increased levels of mRNA transcripts. ETA and ETB induced contrasting reactions in vivo. In rabbits, ETB was moderately pyrogenic and enhanced susceptibility to lethal shock, while ETA lacked both activities. Predictions based on comparisons with other superantigens suggest molecular regions potentially involved in receptor binding in the ETA crystal structure and a modeled ETB three-dimensional structure. These results show that ETs are superantigens with unique properties that could account for the discrepancies reported.
Towards Inverse Estimation of Properties, Process Parameters and Residual Effects for Friction Stir Welding (2015)

Forward and inverse modeling of the friction stir welding (FSW) process is an important endeavor that can be used to optimize process parameters that play a significant role on achieving manufactured part specification requirements. One such requirement is the minimization of permanent deformation induced by the plastically deformed zone close and inside the stirred zone. However, at the same time modeling FSW requires the estimation of process parameters that are not directly measurable. In this work we present a computational framework for applying an inverse approach for the heat conduction equation with experimentally guided volume heat source term that can be used to identify such parameters and subsequently use them for solving the associated forward coupled thermo-plastic problem in a Lagrangian frame of reference. We demonstrate the versatility of our framework by determining the feasibility of determining plastic (and hence residual) deformation.
Publisher’s Note: “Communication: Ion mobility of the radical cation dimers: (Naphthalene)2+• and naphthalene+•-benzene: Evidence for stacked sandwich and T-shape structures” [J. Chem. Phys. 142, 191102 (2015)] (2015)

First Page
Fast GDCI heated air intake system (2023)

A GDCI engine control system includes a fast electric heater located within a pocket in a cylinder head. The pocket is in fluid communication with multiple intake ports. A heater control system includes a capacitor that is configured to provide a voltage that is greater than battery voltage to more quickly heat the intake air during a cold start. Subsequently a lower voltage can be supplied to the heater.
Synthesis, Structures, Photoluminescent Behaviors, and DFT Studies of Novel Aluminum Complexes Containing Phenoxybenzotriazole Derivatives (2009)

Treatment of AlMe3 with 2 equiv of 2-(2H-benzo[d][1,2,3]triazol-2-yl)-4,6-di-tert-pentylphenol (Lig1H) or 2-tert-butyl-6-(5-chloro-2H-benzo[d][1,2,3] triazol-2-yl)-4-methylphenol (Lig2H) and subsequent addition of ROH afford monomeric and heteroleptic (OR)AlL2 complexes [R = C6H5, L = Lig1, 1; R = p-C6H4Ph, L = Lig1, 2; R = C6H5, L = Lig2, 3; R = p-C6H4Ph, L = Lig2, 4]. The simple reaction between a quantitative amount of water and compound 1 gave the novel dimeric aluminum complex 5 bridged by an oxygen atom. The crystal structures of 1, 3, and 5 determined from X-ray diffraction studies reveal pentacoordination geometry around the Al center with the preference for the slightly distorted trigonal-bipyramidal geometry. Monomeric complexes 1−4 showed emissions of the blue region (475 nm) with broad emission areas (half-width of peak = 150 nm) in the emission spectrum with high quantum yield. Dimeric aluminum complex 5 with enhanced thermal stability has a similar absorption and emission pattern to complexes 1 and 2, as predicted by DFT calculations. The DFT calculations suggested that the HOMO and LUMO orbitals are localized on the phenoxy group and benzotriazole group of the ligand and the effect of the phenoxide ligand is negligible.
Evaluation of heavy chain C‐terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells (2017)

Monoclonal antibodies (mAbs) have been well established as potent therapeutic agents and are used to treat many different diseases. During cell culture production, antibody charge variants can be generated by cleavage of heavy chain (HC) C-terminal lysine and proline amidation. Differences in levels of charge variants during manufacturing process changes make it challenging to demonstrate process comparability. In order to reduce heterogeneity and achieve consistent product quality, we generated and expressed antibodies with deletion of either HC C-terminal lysine (-K) or lysine and glycine (-GK). Interestingly, clones that express antibodies lacking HC C-terminal lysine (-K) had considerably lower specific productivities compared to clones that expressed either wild type antibodies (WT) or antibodies lacking HC glycine and lysine (-GK). While no measurable differences in antibody HC and LC mRNA levels, glycosylation and secretion were observed, our analysis suggests that the lower specific productivity of clones expressing antibody lacking HC C-terminal lysine was due to slower antibody HC synthesis and faster antibody degradation. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:786-794, 2017.
Local stereo cues for estimating coplanar surface alignment (2004)

Previous reports indicate that there is a special sense involved in coplanar alignment of isolated surface patches (Taroyan et al., 2000). There have been no quantitative tests of this claim. We tested it by comparing stereo-slant discrimination thresholds for a test surface patch with a coplanar or a non-coplanar reference surface present. Thresholds were lower with the coplanar than with the non-coplanar reference surface. This result suggests that a common surface could be estimated from cues derived from local surface patches. Backus et al. (1999) proposed a retinal cue for coplanar judgments that is independent of distance and azimuth: HSR/VSR^2 which is constant on a plane. However, non-coplanar surfaces will have the same ratio if they intersect at a point on the interocular axis. We investigated whether coplanar judgments worsened when the ratio cue was made ambiguous. In each trial, two surfaces were presented. The reference surface had a fixed slant and distance. A test surface from two surface families was presented at different distances. One family had the same HSR/VSR^2 as a reference surface, but different slants. The other had the same slant as a reference surface, but different values of HSR/VSR^2. Observers judged whether the test surface was closer or farther away than the extended surface of the reference (i.e., coplanar). If observers relied solely upon HSR/VSR^2 to make coplanar judgments, the constant-ratio condition should have higher thresholds than the constant-slant condition. The thresholds for the two stimulus configurations were not significantly different, which suggests that the ratio is not used to judge coplanar alignment, or that the cue is no more informative than other available cues.
ChemInform Abstract: Molecular Modelling of Carboranes Using Distance Restraints: The Molecular Dynamics Simulation of Appended Thioether Macrocycles (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
MicroBlaze-Based Multiprocessor Embedded Cryptosystem on FPGA for Elliptic Curve Scalar Multiplication Over Fp (2018)

In this paper, we present Microblaze-based parallel architectures of Elliptic Curve Scalar Multiplication (ECSM) computation for embedded Elliptic Curve Cryptosystem (ECC) on Xilinx FPGA. The proposed implementations support arbitrary Elliptic Curve (EC) forms defined over large prime field ([Formula: see text]) with different security-level sizes. ECSM is performed using Montgomery Power Ladder (MPL) algorithm in Chudnovsky projective coordinates system. At the low abstraction level, Montgomery Modular Multiplication (MMM) is considered as the critical operation. It is implemented within a hardware Accelerator MMM (AccMMM) core based on the modified high radix, [Formula: see text] MMM algorithm. The efficiency of our parallel implementations is achieved by the combination of the mixed SW/HW approach with Multi Processor System on Programmable Chip (MPSoPC) design. The integration of multi MicroBlaze processor in single architecture allows not only the flexibility of the overall system but also the exploitation of the parallelism in ECSM computation with several degrees. The Virtex-5 parallel implementations of 256-bit and 521-bis ECSM computations run at 100[Formula: see text]MHZ frequency and consume between 2,739 and 6,533 slices, 22 and 72 RAMs and between 16 and 48 DSP48E cores. For the considered security-level sizes, the delays to perform single ECSM are between 115[Formula: see text]ms and 14.72[Formula: see text]ms.
Quantitative tabletop coherent diffraction imaging microscope for EUV lithography mask inspection (2014)

Coherent diffraction imaging (CDI) has matured into a versatile phase-contrast microscopy technique capable of producing diffraction limited images without the need for high precision focusing elements. CDI has been most appropriately applied in the EUV/X-ray region of the spectrum where imaging optics are both difficult to produce and inefficient. By satisfying basic geometric constraints (such as Nyquist sampling of scattered intensities) diffraction imaging techniques essentially replace any imaging elements with sophisticated computer algorithms. We demonstrate the utility of our CDI-based, phase-contrast EUV microscope by quantitatively imaging objects in both transmission and reflection. Patterned feature depth is obtained in transmission using keyhole coherent diffraction imaging (KCDI) and feature height is quantitatively extracted in the first general, table-top reflection mode CDI microscope.
RESCUE - reduction of MR-SNR-degradation by using an MR-synchronous low interfering PET acquisition technique (2014)

The combination of PET and MRI is a challenging task, since both imaging modalities might influence each other. For unaffected imaging performance, PET detectors need to be untouched by the MR operation (MR-compatible) and RF-silent. The latter requirement is demanding, as the digital Data Acquisition and Control Architecture (DACA) produce noise in the MRI receive chain and thus deteriorate the Signal-to-Noise Ratio (SNR). To reduce these MRI-SNR degradations, we propose “RESCUE”, a MR-synchronously gated PET data acquisition technique. By controlling the PET-modules’ digital data acquisition in terms of interrupting the digital SiPM (dSiPM) operation during the MR signal receive phases, potential RF interferences can be reduced. The concept and design of RESCUE are based on the DACA of Hyperion-IID using 960 dSiPMs from Philips which are spread over 10 PET modules, every module containing 6 detector stacks. 16 dSiPMs are populated on one detector stack and a local FPGA per stack is used to clock and configure the dSiPMs and acquire data from them.

To interrupt the PET data acquisition when the MRI is in receive-mode, an MRI trigger signal is sent via the backbone of the PET insert to all PET modules. In the stacks, the dSiPM-operation is interrupted by gating the dSiPMs’ input clock signals. This clock switch-off needs to be performed at a point in time when no dSiPM cell recharge takes place, as sensor-damage might otherwise occur.

We implemented FPGA firmware to stop the above described dSiPM operation and to restart it upon release of the gating. PET-data was acquired using gating-sequences and analysis of sensor data acquired before and after interruption showed that the sensors were working properly after reapplying their clock signals.

More details and MRI SNR-measurement results to demonstrate the interference reduction obtained with RESCUE will be presented at the conference.
Dynamically Reconfigurable Liquid-Core Liquid-Cladding (L 2 ) Lens in a Microfluidic Channel (2008)

We form a liquid lens by flowing liquids in a microchannel with lateral expansion. The resulting biconvex fluidic structure focuses light. Changing flow conditions reconfigures the shape and focus of this lens in real time.
Synthesis and Crystal Structure of a (η5‐C5H5)(CO)2‐Molybdenum Bicyclophosphoranide: The first Transition Metal Complex with a “R4P⊖”‐Ligand (1981)

Tetravalent phosphorus with negative charge is present in a phosphoranide. The ligand (1), formally a phosphoranide, is contained in the title compound, which, moreover, is characterized by a MoPO three-membered ring (X-ray structure analysis). Such a ring has not been observed before.
Absence of NF-κB Activation by a New Polystyrene-Type Adsorbent Designed for Hemoperfusion (2004)

The new BetaSorb device not only appears to be highly biocompatible, but shares properties that make it probably able to interfere with the activation of the inflammatory state.
Opportunities for non-dissipative computation [adiabatic logic] (2002)

Recent advances in adiabatic or non-dissipative computation, as reflected in conceptions of novel static and dynamic energy recovery logic families, are described. The energy, power and peak power of these logic families are compared with conventional static and dynamic CMOS. Key challenges to successful implementation of adiabatic systems are summarized.
Feedforward ripple cancellation for a full-bridge converter (2002)

This paper presents a feedforward ripple cancellation technique for use with a full-bridge DC-DC converter. The full-bridge is used to energize an inductive coupling that serves as an isolating connector in a battery charging system. Feedforward ripple cancellation prevents large AC currents from flowing into the battery terminals in response to unavoidable AC ripple on the inverter input bus voltage. A computationally inexpensive technique for implementing ripple cancellation using either analog or digital hardware is described and demonstrated on a 1500 watt hardware prototype.
A Wasserstein Minimum Velocity Approach to Learning Unnormalized Models (2020)

Score matching provides an effective approach to learning flexible unnormalized models, but its scalability is limited by the need to evaluate a second-order derivative. In this paper, we present a scalable approximation to a general family of learning objectives including score matching, by observing a new connection between these objectives and Wasserstein gradient flows. We present applications with promise in learning neural density estimators on manifolds, and training implicit variational and Wasserstein auto-encoders with a manifold-valued prior.
Anycast Planning in Space Division Multiplexing Elastic Optical Networks With Multi-Core Fibers (2016)

Elastic optical networks (EONs) play an important role for the next generation core networks, especially for supporting cloud computing. However, network traffic has been growing exponentially and almost reached the physical capacity limit of single-mode fibers. Space division multiplexing (SDM) can be potentially employed to increase the fiber capacity. Multi-core fibers (MCFs) make use of SDM to aggregate multiple cores together into the cladding of one fiber, which can greatly increase the capacity of EONs but incurs new crosstalk constraints. Anycast is more flexible as compared with unicast, and anycast communications are widely used in cloud computing, distributed computing, distributed storage system, and content delivery networks. This letter formulates the anycast planning problem in the SDM EONs with MCFs. Evaluation results show that CVX and Gurobi tools can solve small size problems, but do not scale well. Therefore, we propose a heuristic algorithm to efficiently solve the problem. To the best of our knowledge, this is the first work that considers ancyast routing in the SDM EONs with MCFs.
<p>Tumor-Draining Lymph Secretome En Route to the Regional Lymph Node in Breast Cancer Metastasis</p> (2020)

Proteins and exosomal proteins in lymph draining a metastatic tumor are different from those in lymph draining non-metastatic tumors, and these proteins involved in pathways that regulate tumor cells migration and invasion.
Slice-based column generation for network slicing (2018)

We propose an algorithmic framework for network slicing based on column generation. It aims at efficiently maximizing the number of accepted slices while minimizing the cost of embedding virtual networks. It can address key QoS and high reliability constraints for 5G networks and it extensively uses parallelization to quickly solve a relaxed version of the problem and round it to a near-optimal integer solution. This poster presents performance results on small and large problem instances.