gebhart/patrepeval huggingface dataset:
Role of Bradykinin in Protection of Ischemic Preconditioning in Rabbit Hearts (1995)

Bradykinin receptor activation has been proposed to be involved in ischemic preconditioning. In the present study, we further investigated the role of this agent in preconditioning in both isolated and in situ rabbit hearts. All hearts were subjected to 30 minutes of regional ischemia followed by reperfusion for 2 hours (in vitro hearts) and 3 hours (in situ hearts). Infarct size was measured by tetrazolium staining and expressed as a percentage of the size of the risk zone. Preconditioning in situ hearts with 5 minutes of ischemia and 10 minutes of reperfusion significantly reduced infarct size to 10.2 +/- 2.2% of the risk region (P < .0005 versus control infarct size of 36.7 +/- 2.6%). Pretreatment with HOE 140 (26 micrograms/kg), a bradykinin B2 receptor blocker, did not alter infarct size in nonpreconditioned hearts (40.6 +/- 5.3% infarction) but abolished protection from ischemic preconditioning (34.1 +/- 1.6% infarction). However, when HOE 140 was administered during the initial reflow period following 5 minutes of ischemia, protection was no longer abolished (15.6 +/- 3.9% infarction versus 13.3 +/- 3.8% without HOE 140, P = NS). Bradykinin infusion in isolated hearts mimicked preconditioning, and protection was not affected by pretreatment with the nitric oxide synthase inhibitor N omega-nitro-L-arginine methyl ester or the prostaglandin synthesis inhibitor indomethacin but could be completely abolished by the protein kinase C (PKC) inhibitors polymyxin B and staurosporine as well as by HOE 140. HOE 140 could not block the protection of ischemic preconditioning in isolated hearts. That failure was apparently due to the absence of blood-borne kininogens rather than autonomic nerves. When the preconditioning stimulus in the in situ model was amplified with four cycles of 5-minute ischemia/10-minute reperfusion, HOE 140 pretreatment could no longer block protection (infarct size was 10.7 +/- 3.5% versus 6.4 +/- 2.0% without HOE 140, P = NS). We propose that bradykinin receptors protect by coupling to PKC as do adenosine receptors, and blockade of either receptor will diminish the total stimulus of PKC below threshold and prevent protection. A more intense preconditioning ischemic stimulus can overcome bradykinin receptor blockade, however, by simply enhancing the amount of adenosine and possibly other agonists released.
Enhancing the 5G-V2X Sidelink Autonomous Mode through Full-Duplex Capabilities (2022)

Efforts are underway to finalize the fifth generation (5G) vehicle-to-everything (V2X) communication technology. Direct communication among vehicles over the sidelink interface through the autonomous selection of radio resources is among the main and more challenging capabilities of such a connectivity solution. Nonetheless the crucial enhancements conceived by the Third Generation Partnership Project (3GPP) in Release 16, the autonomous resource allocation (a.k. a. Mode 2) still suffers from collisions due to the wrong estimation of the resource occupancy status enforced by half-duplex (HD) transceivers. In this paper, we argue in favour of the usage in vehicles of in-band full-duplex (FD) transceivers, gaining momentum in the research towards sixth generation (6G) systems thanks to their simultaneous transmission and reception capability. Exploiting FD, we propose to enhance the autonomous mode by detecting collisions and triggering resource reselection procedures in a more conscious manner. Simulation results show that the conceived proposal allows sidelink V2X to achieve significant improvements in terms of reliability and timeliness when compared against the legacy Mode 2.
Tunable 3-D MEMS components for reconfigurable RF front-ends (2011)

The implementation of a fully reconfigurable Cognitive Radio (CR) system relies heavily on the availability of high-quality reconfigurable RF components. This paper gives a review of the recent progress made in realizing high-performance tunable RF MEMS components for reconfigurable RF front-ends. The concept of the highly-tunable high-Q evanescent-mode tunable resonator is first discussed. Several practical considerations, such as power handling, noise and vibration perturbations are subsequently considered. These high performance tunable RF components are expected to make a significant impact on the development of reconfigurable RF systems.
SOI ring resonators with controllable MMI coupler sections (2011)

A ring resonator using a single 2&times;2 MMI as the coupler section has the distinct advantages of low sensitivity to fabrication error, temperature, wavelength and polarisation. However, the coupling coefficient of the 2&times;2 MMI coupler is fixed; hence, the performance of this type of device is limited, e.g. transmission spectrum with high extinction ratio is difficult to achieve. We have designed and simulated ring resonators with coupler sections consisting of two 2&times;2 MMIs and phase shifters, so that the coupling efficiency can be varied from 0% to 100% with relative ease. For a single ring resonator, the transmission spectrum can be controlled to achieve an extinction ratio of &gt;20dB and a spectral bandwidth of &lt;1nm. For a multiple ring filter, the transmission spectrum can be controlled to achieve an extinction ratio of &gt;30dB and a bandwidth of &lt;1nm; in addition, a flat-top transmission spectrum is also achievable. The whole device has a footprint of approximately 200&mu;m by 100&mu;m.
Data from JAGGED1 Expression Is Associated with Prostate Cancer Metastasis and Recurrence (2023)

&lt;div&gt;Abstract&lt;p&gt;Recent studies suggest that NOTCH signaling can promote epithelial-mesenchymal transitions and augment signaling through AKT, an important growth and survival pathway in epithelial cells and prostate cancer in particular. Here we show that JAGGED1, a NOTCH receptor ligand, is significantly more highly expressed in metastatic prostate cancer as compared with localized prostate cancer or benign prostatic tissues, based on immunohistochemical analysis of JAGGED1 expression in human tumor samples from 154 men. Furthermore, high JAGGED1 expression in a subset of clinically localized tumors was significantly associated with recurrence, independent of other clinical parameters. These findings support a model in which dysregulation of JAGGED1 protein levels plays a role in prostate cancer progression and metastasis and suggest that JAGGED1 may be a useful marker in distinguishing indolent and aggressive prostate cancers.&lt;/p&gt;&lt;/div&gt;
Clinical and Economic Burden of Emergency Department Visits Due to Gastrointestinal Diseases in the United States (2013)

GI illnesses account for substantial clinical and economic burdens on US emergency medical services.
Capturing Shared and Individual Information in fMRI Data (2018)

Cognitive neuroscience seeks to explain the organization of the brain, but typically focuses on aspects that are shared across people rather than those that vary across individuals. Here, we present a new method for analyzing brain imaging data that captures both shared and individual components of brain activity. Inspired by the shared response model (SRM) and the robust principal components analysis, the robust shared response model (RSRM) aligns functional topographies across humans while preserving a component of sparse, individual activity. Experimental results on adult data showed that RSRM performs as well as or better than SRM, while at the same time capturing reliable markers of individual variability. In a test case of participants with extreme variability, we found that RSRM was able to improve the accuracy more than 60% over SRM for the coding of infant fMRI data.
16 QAM synthesis by angular superposition of polarization using dual-polarization QPSK modulator (2010)

We propose a polarization-multiplexing QPSK modulator for 16 QAM generation. 16 QAM is synthesized from two QPSK signals with orthogonal polarization by a polarizer. Generation of 40 Gb/s 16 QAM with the BER of 8.13×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> was demonstrated.
Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge (2023)

Abstract Despite numerous clinically available vaccines and therapeutics, aged patients remain at increased risk for COVID-19 morbidity and mortality. Furthermore, the aged patient population has suboptimal responses to SARS-CoV-2 vaccine antigens. Here, we characterized vaccine-induced responses to SARS-CoV-2 synthetic DNA vaccine antigens in aged mouse models. Aged mice had altered cellular responses, including decreased IFNγ secretion and increased TNFα secretion as compared to young mice. Aged mice had significantly decreased binding and neutralizing antibodies in their serum compared to their young counterparts. Co-immunization with the plasmid-encoded molecular adjuvant adenosine deaminase-1 (pADA) enhanced cellular responses and expanded the breadth and affinity of humoral responses in aged mice. pADA co-delivery also altered the gene expression profiles of lymph node lymphocytes in aged animals. scRNAseq analysis of aged lymph nodes revealed that pADA co-immunization supported a strong TH1 gene profile and decreased FoxP3 gene expression. Upon challenge pADA co-immunization decreased viral loads and age-associated morbidity and mortality in mouse-adapted and ACE2 transgenic SARS-CoV-2 challenge models. These data support the use of aged mice as a model for age-associated decreases in vaccine immunogenicity and increased in infection-mediated morbidity and mortality in the context of SARS-CoV-2. These studies provide further support for the use of adenosine deaminase as a molecular adjuvant in the elderly. This work was supported by NIH NCI award T32 CA09171 (ENG) and NIH NIAID award T32-AI-055400 (EMP) and The Wistar Institute coronavirus discovery fund with additional support from CEPI/Inovio Pharmaceuticals.
Influence of Damping Constant .ALPHA. on Recording Characteristics at High Frequencies. (1999)

The influence of the damping constant α on recording characteristics at high frequencies was simulated by using the Langevin equation, with the condition that the head field rise time is constant. In the frequency range up to 190 MHz the signal outputs for α = 1 and α = 0.05 are same. On the other hand, in the higher- frequency range over 190 MHz, where the head field decreases before it reaches the maximum value, the signal outputs for α = 0.05 are larger than those for α =1.0. This is because the critical switching field depends on the damping constant α and it decreases with a lower value of α.
A 170-dB $\Omega $ CMOS TIA With 52-pA Input-Referred Noise and 1-MHz Bandwidth for Very Low Current Sensing (2017)

A fully integrated current sensing interface chip employing a capacitive-feedback transimpedance amplifier (TIA) is presented. A robust dc current removal block is proposed to prevent the dc portion of the input current from saturating the output voltage. This block allows the TIA to operate in the presence of a wide range of input dc currents, and the cancellation loop is designed to enhance its stability. The TIA is fully integrated in a standard 0.13 μm CMOS technology, and a gain of 170 dBΩ is achieved without requiring any off-chip resistors. The integrated input-referred current noise of the interface circuit is 0.4, 3.8, and 52 pARMS within 0.01, 0.1, and 1 MHz integration bandwidths, respectively.
Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab (2014)

Background: Inhibition of the activated epidermal growth factor receptor (EGFR) with either enzymatic kinase inhibitors or anti-EGFR antibodies such as cetuximab, is an effective modality of treatment for multiple human cancers. Enzymatic EGFR inhibitors are effective for lung adenocarcinomas with somatic kinase domain EGFR mutations while, paradoxically, anti-EGFR antibodies are more effective in colon and head and neck cancers where EGFR mutations occur less frequently. In colorectal cancer, anti-EGFR antibodies are routinely used as second-line therapy of KRAS wild-type tumors. However, detailed mechanisms and genomic predictors for pharmacological response to these antibodies in colon cancer remain unclear. Findings: We describe a case of colorectal adenocarcinoma, which was found to harbor a kinase domain mutation, G724S, in EGFR through whole genome sequencing. We show that G724S mutant EGFR is oncogenic and that it differs from classic lung cancer derived EGFR mutants in that it is cetuximab responsive in vitro, yet relatively insensitive to small molecule kinase inhibitors. Through biochemical and cellular pharmacologic studies, we have determined that cells harboring the colon cancer-derived G719S and G724S mutants are responsive to cetuximab therapy in vitro and found that the requirement for asymmetric dimerization of these mutant EGFR to promote cellular transformation may explain their greater inhibition by cetuximab than small-molecule kinase inhibitors. Conclusion: The colon-cancer derived G719S and G724S mutants are oncogenic and sensitive in vitro to cetuximab. These data suggest that patients with these mutations may benefit from the use of anti-EGFR antibodies as part of the first-line therapy.
Effect of Mixed Layer Crystallinity on the Performance of Mixed Heterojunction Organic Photovoltaic Cells (2014)

Organic vapor-phase deposition (OVPD) is used to grow tetraphenyldibenzoperiflanthen (DBP):C70 mixed heterojunction photovoltaic devices. Compared with vacuum thermal evaporation (VTE), the OVPD-grown film develops nanocrystalline domains of C70. Optimized OVPD-grown OPVs have a 61% fill factor for a 100 nm active layer thickness, whereas VTE-grown devices have a 47% fill factor at the same thickness.
Anatomical total shoulder replacement with rotator cuff repair for osteoarthritis of the shoulder (2014)

We assessed the clinical results, radiographic outcomes and complications of patients undergoing total shoulder replacement (TSR) for osteoarthritis with concurrent repair of a full-thickness rotator cuff tear. Between 1996 and 2010, 45 of 932 patients (4.8%) undergoing TSR for osteoarthritis underwent rotator cuff repair. The final study group comprised 33 patients with a mean follow-up of 4.7 years (3 months to 13 years). Tears were classified into small (10), medium (14), large (9) or massive (0). On a scale of 1 to 5, pain decreased from a mean of 4.7 to 1.7 (p = < 0.0001), the mean forward elevation improved from 99° to 139° (p = < 0.0001), and the mean external rotation improved from 20° (0° to 75°) to 49° (20° to 80°) (p = < 0.0001). The improvement in elevation was greater in those with a small tear (p = 0.03). Radiographic evidence of instability developed in six patients with medium or large tears, indicating lack of rotator cuff healing. In all, six glenoid components, including one with instability, were radiologically at risk of loosening. Complications were noted in five patients, all with medium or large tears; four of these had symptomatic instability and one sustained a late peri-prosthetic fracture. Four patients (12%) required further surgery, three with instability and one with a peri-prosthetic humeral fracture. Consideration should be given to performing rotator cuff repair for stable shoulders during anatomical TSR, but reverse replacement should be considered for older, less active patients with larger tears.
David Mason (ed.), Explaining Ethnic Differences: Changing Patterns of Disadvantage in Britain, The Policy Press, Bristol, 2003, vii + 182 pp., £21.99 pbk, ISBN 1861344678 (2004)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Response clustering in transient stochastic synchronization and desynchronization of coupled neuronal bursters (2007)

We studied the transient dynamics of synchronized coupled neuronal bursters subjected to repeatedly applied stimuli, using a hybrid neuroelectronic system of paddlefish electroreceptors. We show experimentally that the system characteristically undergoes poststimulus transients, in which the relative phases of the oscillators may be grouped in several clusters, traversing alternate phase trajectories. These signature transient dynamics can be detected and characterized quantitatively using specific statistical measures based on a stochastic approach to transient oscillator responses.
Replication Data for: The effect of frustrated rotations on the pre-exponential factor for unimolecular reactions on surfaces: a case study of alkoxy dehydrogenation (2021)

The data underlying this published work have been made publicly available in this repository as part of the IMASC Data Management Plan. This work was supported as part of the Integrated Mesoscale Architectures for Sustainable Catalysis (IMASC), an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences under Award # DE-SC0012573.
Lamellar Diblock Copolymer Grain Boundary Morphology. 3. Helicoid Section Twist Boundary Energy (1997)

The helicoid section morphology allows a diblock copolymer lamellar phase to maintain microphase separation across a twist grain boundary. The interface between the two microphases in the grain boundary region approximates a stack of sections of the helicoid minimal surface. Grain boundary energies were calculated for the helicoid section morphology both as a function of diblock chain characteristics and as a function of grain boundary twist angle. The basic approach to grain boundary energy calculation is to formulate a general expression for local free energy density as a function both of chain characteristics and of the local curvature of the interface. The local energy density is then integrated over the mathematical model for the Scherk grain boundary. Two general methods of calculation were used, and the results where then compared. First, a self-consistent field model was formulated in which average energies per chain were calculated for all the possible interfacial curvature environments encountered by diblocks in the helicoid section morphology. A second general approach utilized a continuum (Helfrich) model for interfacial deformation in which moduli are used to impose energetic penalties for curvature of the interface in the grain boundary region. The helicoid section grain boundary energies were compared to energies of a competing twist boundary morphology, the Scherk surface, which was analyzed in the preceding paper of this series. It was found that the energies of both the Scherk morphology and the helicoid section increase with increasing twist. The Scherk and helicoid section energies are comparable at low twist angles, less than about 15°. Both morphologies are observed in this twist range. For higher twist angles, where only the Scherk morphology is observed, the helicoid section boundary energy becomes prohibitively high due to a compression of the lamellar layers.
Optical ceramics for fast scintillator materials (2013)

The chapter reviews the latest studies in the field of fast scintillation optical ceramics in the last decade focusing on the interconnection among the manufacturing technology, scintillation performance and defect ocurrence and nature in the discussed material systems. The most studied group of materials are the cubic structure aluminum or multicomponent garnets, but interesting results have been achieved also in sesquioxide, silicate, hafnate, complex perovskite or rare earth halide compounds. Both basic physics and application aspects are considered in the description of the above mentioned systems.
Cavity-enhanced direct band electroluminescence near 1550 nm from germanium microdisk resonator diode on silicon (2011)

We electrically and optically characterize a germanium resonator diode on silicon fabricated by integrating a germanium light emitting diode with a microdisk cavity. Diode current-voltage characteristics show a low ideality factor and a high on/off ratio. The optical transmission of the resonator features whispering gallery modes with quality factors of a few hundred. Direct band gap electroluminescence under continuous current injection shows a clear enhancement of emission by the cavity. At this stage, the pumping level is not high enough to cause linewidth narrowing and invert the material. A higher n-type activated doping of germanium is necessary to achieve lasing.
Nanometric hollow spheres made of MSU-X-type mesoporous silica (2002)

Submicrometric hollow spheres with mesoporous walls were prepared by applying the synthesis of MSU-X type mesoporous silica at neutral pH. The application of ultrasound in the proper power range, to a mixture of nonionic polyoxyethylene surfactant and unreacted silicon alkoxide (tetraethylorthosilicate) gives a stable emulsion where the cavitation bubbles created by the ultrasound are trapped in the solution. Further hydrolysis and condensation of the silica by the addition of sodium fluoride freezes the structure and gives a powder that exhibits a single reflection in the X-ray diffraction pattern, characteristic of a 3D-wormhole ordered porous framework. Its main feature is a large hysteresis loop in the nitrogen adsorption/desorption isotherm. This hysteresis loop corresponds to the retention of condensed nitrogen within the voids of these particles that can play the role of tanks for volatile compounds.
Modeling the Formation of Polyimide Microspheres (2002)

High temperature polyimide microspheres have been developed from polyimide solid residuum by a simple inflation process. Microspheres have been fabricated from several polyimide precursors through the use of a circulating air oven. Microsphere formation and final physical property characterization have been limited to simple mechanical and thermal testing. The present paper focuses on developing an understanding of microsphere formation through simple geometric rules for an incompressible polymeric material and microscopic observations of precursor residuum inflation. Inflation kinematics of the hollow polyimide microspheres as a function of time and temperature is discussed.
On the Filler Flocculation in Silica-Filled Rubbers Part I. Quantifying and Tracking the Filler Flocculation and Polymer-Filler Interactions in the Unvulcanized Rubber Compounds (2002)

Abstract Filler flocculation was followed for silica filled compounds containing various alkoxy silanes and non-silane type polar additives. The methodology employed in this paper permitted a quantitative characterization of filler flocculation and polymer-filler interactions after heating the compound under conditions that simulated vulcanization. With the addition of trialkoxy silanes, the reduction of filler flocculation and the degree of polymer-filler interactions were found to depend on the type and the concentration of silane added, and on the mixing drop temperature ( T d ) used. Greater polymer-filler interactions and flocculation suppression were obtained with a compound containing a tetrasulfane when compared to that containing either a disulfane or a monofunctional-silane. Polar additives such as an amine compound and a sugar alcohol did not reduce the silica flocculation during simulated vulcanization because they were dewetted from the silica surface upon heating. The filler flocculation process was monitored by following the change of dynamic storage moduli using an on-line rheometer. The flocculation process order and process constant were extracted from the non-linear regression analysis of the kinetic data. These kinetic parameters were used to quantify the suppression of filler flocculation by the additives used. Filler flocculation was found not to be affected by the vulcanization process because it occurred prior to the onset of cure.