gebhart/patrepeval huggingface dataset:
Consistently large amyloid reductions in patients with and without ARIA-E in the gantenerumab SCarlet RoAD and Marguerite RoAD open-label extension studies (S9.007) (2019)

To characterize amyloid reductions among patients with and without amyloid-related imaging abnormalities– edema (ARIA-E) during the open-label extension (OLE) of the SCarlet RoAD (SR; NCT01224106) and Marguerite RoAD (MR; NCT02051608) studies of gantenerumab in patients with Alzheimer’s disease (AD).
Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1 (2008)

The cytoplasmic repressor Keap1 regulates the function of transcription factor Nrf2 which plays critical roles in oxidative and xenobiotic stresses. The Neh2 domain of Nrf2 interacts with Keap1 at the bottom region of the Kelch/beta-propeller domain which is formed by double-glycine repeat and C-terminal region domains (Keap1-DC). The structure of Keap1-DC complexed with an Nrf2 peptide containing a conserved DLG motif has been determined at 1.9 A resolution. The Keap1-bound DLG peptide possesses a hairpin conformation, and it binds to the Keap1 protein at the bottom region of the beta-propeller domain. The intermolecular interaction occurs through their complementary electrostatic interactions. Comparison of the present structure with the recently reported Keap1-DC complex structure suggests that the DLG and ETGE motifs of Neh2 in Nrf2 bind to Keap1 in a similar manner but with different binding potencies.
Mood State and Behavior Predictions in Social Media through Unstructured Data Analysis (2019)

For mood State and Behavior Predictions in Social Media through Unstructured Data Analysis, a new model, Behavior Dirichlet Probability Model (BDPM), which can capture the Behavior and Mood of user on Social media is proposed using Dirichlet distribution. There is a colossal amount of data being generated regularly on social media in the form of text from various channels by individuals in the form of posts, tweets, status, comments, blogs, reviews etc. Most of it belongs to some conversation where real-world individuals discuss, analyze, comment, exchange information. Deriving personality traits from textual data can be useful in observing the underlying attributes of the author’s personality which might explain a lot about their behavior, traits etc. These insights of the individual can be utilized to obtain a clear picture of their personality and accordingly a variety of services, utilities would follow automatically. Using Dirichlet probability distribution, the aim is to estimate the probability of each personality trait (or mood state) for an author and then model the latent features in the text which are not captured by the BDPM. As a result, the study can be helpful in prediction of mood state/personality trait as well as capturing the significance of the latent features apart from the ones present in the taxonomies, which will help in making an improved mood state or personality prediction.
A Peptide-Fc Opsonin with Pan-Amyloid Reactivity (2017)

There is a continuing need for therapeutic interventions for patients with the protein misfolding disorders that result in systemic amyloidosis. Recently, specific antibodies have been employed to treat AL amyloidosis by opsonizing tissue amyloid deposits thereby inducing cell-mediated dissolution and organ improvement. To develop a pan-amyloid therapeutic agent, we have produced an Fc-fusion product incorporating a peptide, p5, which binds many if not all forms of amyloid. This protein, designated Fcp5, expressed in mammalian cells, forms the desired bivalent dimer structure and retains pan-amyloid reactivity similar to the p5 peptide as measured by immunosorbent assays, immunohistochemistry, surface plasmon resonance, and pulldown assays using radioiodinated Fcp5. Additionally, Fcp5 was capable of opsonizing amyloid fibrils <i>in vitro</i> using a pH-sensitive fluorescence assay of phagocytosis. In mice,<sup>125</sup> I-labeled Fcp5 exhibited an extended serum circulation time, relative to the p5 peptide. It specifically bound AA amyloid deposits in diseased mice, as evidenced by biodistribution and microautoradiographic methods, which coincided with an increase in active, Iba-1-positive macrophages in the liver at 48 h postinjection of Fcp5. In healthy mice, no specific tissue accumulation was observed. The data indicate that polybasic, pan-amyloid-targeting peptides, in the context of an Fc fusion, can yield amyloid reactive, opsonizing reagents that may serve as next-generation immunotherapeutics.
17β-Estradiol suppresses visceral adipogenesis and activates brown adipose tissue-specific gene expression (2016)

Both functional ovaries and estrogen replacement therapy (ERT) reduce the risk of type 2 diabetes (T2D). Understanding the mechanisms underlying the antidiabetic effects of 17β-estradiol (E2) may permit the development of a molecular targeting strategy for the treatment of metabolic disease. This study examines how the promotion of insulin sensitivity and weight loss by E2 treatment in high-fat-diet (HFD)-fed mice involve several anti-adipogenic processes in the visceral adipose tissue. Magnetic resonance imaging (MRI) revealed specific reductions in visceral adipose tissue volume in HFD+E2 mice, compared with HFD mice. This loss of adiposity was associated with diminished visceral adipocyte size and reductions in expression of lipogenic genes, adipokines and of the nuclear receptor nr2c2/tr4. Meanwhile, expression levels of adipose triglyceride lipase/pnpla2 and leptin receptor were increased. As mRNA levels of stat3, a transcription factor involved in brown adipose tissue differentiation, were also increased in visceral adipose, the expression of other brown adipose-specific markers was assessed. Both expression and immunohistochemical staining of ucp-1 were increased, and mRNA levels of dio-2, and of adrβ3, a regulator of ucp-1 expression during the thermogenic response, were increased. Furthermore, expression of cpt-1b, a brown adipose-specific gene involved in fatty acid utilization, was also increased. Methylation studies demonstrated that the methylation status of both dio-2 and adrβ3 was significantly reduced. These results show that improved glycemic control and weight loss due to E2 involve anti-adipogenic mechanisms which include suppressed lipogenesis and augmented fatty acid utilization, and in addition, the activation of brown adipose tissue-specific gene expression in association with E2-dependent epigenetic modifications in these genes.
Mechanistic Insights into the Pd‐Catalyzed Direct Amination of Allyl Alcohols: Evidence for an Outer‐Sphere Mechanism Involving a Palladium Hydride Intermediate (2014)

The mechanism of direct amination of allyl alcohol by a palladium triphenylphosphite complex has been explored. Labelling studies show that the reaction proceeds through a π-allylpalladium intermediate. A second-order dependence of reaction rate on allyl alcohol concentration was observed. Kinetic isotope effect studies and ESI-MS studies are in agreement with a reaction proceeding through a palladium hydride intermediate in which both O-H bond and C-O bond cleavages are involved in rate-determining steps. A stereochemical study supports an outer-sphere nucleophilic attack of the π-allylpalladium intermediate giving complete chiral transfer from starting material to product.
Add-drop filters based on mode conversion cavities (2007)

A resonator defined by mode-converting gratings in a waveguide is proposed. This resonator can exhibit narrow resonances similar to Fabry-Perot with an advantage of being a four-port device capable of serving as an add-drop filter.
Live Procedure for Ischemic Heart Failure: Contemporary Short- and Mid-Term Outcomes (2021)

Objectives: Ischemic cardiomyopathy is the principal cause of heart failure. In patients with left ventricular (LV) dilatation, low ejection fraction (EF), and transmural scar in anteroseptal distribution, surgical ventricular reconstruction (SVR) can be considered, although it is an invasive surgical procedure. Less Invasive Ventricular Enhancement (LIVE) technique emerged as a unique intervention to exclude scarred myocardium, improving symptoms and quality of life. We aim to present LIVE contemporary short and mid-term outcomes.
Induction of S Phase Arrest of the Cell Cycle by Piceatannol is Associated with Inhibition of Telomerase Activity in Human Leukemic U937 Cells (2008)

이상의 연구 결과에 의하면 piceatannol의 처리에 의한 U937 세포의 증식억제는 세포주기 S기 arrest 및 apoptosis 유발과 뚜렷한 연관성이 있었다. 또한 piceatannol은 hTERT 및 TEP-1 유전자의 발현 저하와 연관된 telomerase 활성의 저하 효과도 나타내었으나, COXs의 발현 및 PGE2의 생성에는 큰 변화를 주지 못하였다. 따라서 본 연구의 결과는 암세포에서 높게 발현되는 telomerase 활성 조절제로서 piceatannol의 적용이 가능함을 보여주며, 이는 piceatannol의 항암작용을 이해하는데 매우 유용한 자료라 생각한다. Piceatannol is a polyphenol that is found in abundant quantities in grapes and wine. Although recent experimental data revealed the anti-cancer potency of piceatannol, the molecular mechanisms underlying the antileukemic activity have not yet been studied in detail. In the present study, we investigated further possible mechanisms by which piceatannol exerts its anti-proliferative action in cultured human leukemia U937 cells. Exposure of U937 cells to piceatannol resulted in growth inhibition and induction of apoptosis as measured by MTT assay and flow cytometry analysis, which was associated with S phase arrest of the cell cycle. Piceatannol treatment markedly inhibited the activity of telomerase, and the levels of human telomerase reverse transcriptase (hTERT) and telomerase-associated protein-1 (TEP-1), main determinants of the telomerase enzymatic activity, were progressively down-regulated by piceatannol treatment in a dose-dependent fashion. However, the levels of cyclooxygenases (COXs) expression and prostaglandin E2 (PGE2) release were not changed in piceatannol-treated U937 cells. Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of piceatannol.
A study of the motion of single electrons in liquid helium (2007)

We have developed an apparatus which can be used to monitor the motion of individual electrons in liquid helium. A sound wave is used to explode an electron bubble for a fraction of a microsecond. While the bubble is expanded, it is illuminated by light from a flash lamp. We describe the details of the experiment and show the results we obtained. The phonon-roton in liquid helium drags the electron bubbles across the experiment cell. In some cases, an electron is seen to follow a snakelike path. Our tentative explanation is that the electron is sliding along a quantized vortex line.
Raising Awareness of Conveyed Personality In Social Media Traces (2017)

Users' persistent social media contents like posts on Facebook Timeline are presented as an "exhibition" about the person to others, and managing these exhibitional contents for impression management needs intentional and manual efforts. To raise awareness of and facilitate impression management around past contents, we developed a prototype called PersonalityInsight. The system employs computational psycho-linguistic analysis to help users visualize the way their past text posts might convey impressions of their personality and allowed users to modify their posts based on these visualizations. We conducted a user study to evaluate the design; users overall found that such a tool raised awareness of the fact and the ways personality might be conveyed through their past content as one aspect of impression management, but that it needs design improvement to offer action-able suggestions for content modification, as well as careful thinking about impression management as one of many values people have about their digital past.
Evaluation of S100B in the diagnosis of suspected intracranial hemorrhage after minor head injury in patients who are receiving platelet aggregation inhibitors and in patients 65 years of age and older (2015)

Levels of S100B below 0.105 μg/L can accurately predict normal CCT findings after MHI in older patients and in those treated with PAIs. Combining conventional decision criteria with measurement of S100B can reduce the CCT scan and hospital admission rates by approximately 30%.
Nano-LC-orbitrap MS/MS-based quantitative proteomics and transpcriptomics for uncovering the mechanisms of action of rosemary bioactives in colon cancer: a new foodomics approach (2016)

Resumen del trabajo presentado al 43rd Annual North American Meeting of the Federation of Analytical Chemistry and Spectroscopy Societies: "Great Scientific Exchange", celebrado en Minneapolis, Minnesota (USA) del 18 al 23 de septiembre de 2016.
Predictive nature of IgM anti-α-glucose serum biomarker for relapse activity and EDSS progression in CIS patients: a BENEFIT study analysis (2011)

We could not confirm previous results that gMS-Classifier1 can predict early conversion to MS in CIS. However, raised titres of these antibodies may predict early disability progression in this patient population.
Joint Feature Tracking and Radiometric Calibration from Auto-Exposure Video (2007)

To capture the full brightness range of natural scenes, cameras automatically adjust the exposure value which causes the brightness of scene points to change from frame to frame. Given such a video sequence, we introduce a new method for tracking features and estimating the radiometric response function of the camera and the exposure difference between frames simultaneously. We model the global and nonlinear process that is responsible for the changes in image brightness rather than adapting to the changes locally and linearly which makes our tracking more robust to the change in brightness. The radiometric response function and the exposure difference between frames are also estimated in the process which enables further video processing algorithms to deal with the varying brightness.
Advanced Arsenic Doped Epitaxial Growth for Source Drain Extension Formation in Scaled FinFET Devices (2018)

In this paper, we demonstrate a novel Source Drain Extension (SDE) approach to enable NMOS device scaling along with improved performance. For the first time, SDE formation with epitaxially grown As doped Si (Si:As) has been examined and compared to the current state-of-the-art SDE formation in FinFET at 10nm logic ground rules. It is found that a Si:As layer based SDE provides a clear improvement in the short channel effect and a significant device performance increase. It is also shown that a careful co-optimization of the Si:As layer and Source / Drain (S/D) lateral recess is required to achieve the optimum device gain. This paves the way for the ultimate nSDE formation for current and next generation CMOS devices.
Results of MIS TKA at Mean Nine Year Follow-Up (2011)

The first 103 consecutive minimally invasive total knee arthroplasties performed by a single surgeon were assessed to determine the clinical and radiographic outcomes at a mean of 9-year follow-up (range, 8 to 10 years). Patients who died before final follow-up were 10 (13 knees), leaving 90 knees in 69 patients for final review. Outcome was evaluated using Knee Society pain and functional scores. Survival with revision as an end point was 97.1%. Knee Society scores and range of motion improved significantly to a mean of 96 and 92 points and a mean of 115 degrees, respectively. There were five patients who required surgical intervention for unexplained pain with findings of retained cement and adhesions. Radiographic analysis did not reveal any progressive radiolucencies. These results suggest that excellent long-term outcomes can be achieved with minimally invasive total knee arthroplasty.
Self-aligned printing of high-performance polymer thin-film transistors (2006)

Self-aligned printing (SAP) is a recently developed bottom-up printing technique which utilizes the unique ink droplet motion on heterogeneous surfaces to define nanoscale critical features with high yield and uniformity. It was originally developed with conductive polymers. Here we extend this method to fabrication of functional conductive nanostructures with gold nanoparticle ink that allow achieving much higher conductivities. Channel lengths down to 60 nm were achieved by controlling the motion of the droplet contact line. The higher conductivity of gold results in significantly improved thin-film transistor (TFT) performance. We will discuss the device physics of these printed submicron organic transistors, provide an update on our ongoing work to improve device scaling and further reduce parasitic capacitance, and realize high-performance printed submicrometer OTFT devices and circuits
Reader Response: Blood Biomarkers of Traumatic Brain Injury and Cognitive Impairment in Older Veterans (2021)

The article by Peltz et al.1 provides a nice example of differences in neurodegenerative biomarkers which can be found in patients with chronic traumatic brain injury (TBI) using blood samples enriched for CNS-derived exosomes. However, these differences seem driven more by the presence of cognitive impairment (CI) rather than the history of TBI itself. Based on the cohort studied (older veterans), there is no proven causality demonstrating that the CI in the TBI-CI group is actually driven by the remote TBI, which occurred decades previously. This could be an independent clinical finding in the veterans. Because the control group and the TBI-no-CI group did not differ in any of the biomarkers, it seems that the main driver of differences is cognitive impairment, which could be independent from the TBI even in the TBI-CI group. This article has some overlap with a recent study from this group, in which Aβ42 was reported to be elevated for decades after TBI.2 This is not the case in this article, with no clear explanation. One wonders the utility of these biomarkers in a clinical setting because they do not clarify the causes of the CI and are not specific to TBI.
Linee Guida AIAC 2006 all’impianto di pacemaker, dispositivi per la resincronizzazione cardiaca (CRT) e defibrillatori automatici impiantabili (ICD) (2005)

Fin dalla loro prima introduzione, le Linee Guida\nhanno sempre avuto lo scopo di informare il medico\nsulle evidenze scientifiche riportate in letteratura ed\nindirizzarlo verso il trattamento più appropriato di\nspecifiche patologie.\nDebbono cioè identificare dei gruppi di pazienti con\ndeterminate caratteristiche e suggerire per essi il trattamento\nche, in trial clinici randomizzati, abbia dimostrato\ndi garantire il miglior risultato per il paziente.\nPurtroppo, molto spesso non sono disponibili per tutte\nle categorie di pazienti, dati scientifici che evidenzino\ncon chiarezza i potenziali benefici o non benefici di specifici\ntrattamenti e ciò determina l’esistenza di grandi\n“zone grigie” nelle quali, in assenza di supporti scientifici\nchiari, la decisione terapeutica rimane totalmente\nnelle mani del medico curante il quale è chiamato a valutare\nla situazione clinica di ogni paziente su base individuale
Respiratory Medication Devices (2021)

Inhaled respiratory medications are a frontline therapy for patients presenting to the acute care setting with complaints of respiratory distress. Patients with previously diagnosed respiratory problems are often prescribed inhaled medications for use at home with a combination of dry powder inhalers, pressurized metered dose inhaler (pMDI), soft mist inhaler, or a small volume jet nebulizer. Small volume jet nebulizers (SVN) have been in use since the 1930s and are an example of single dose jet nebulizers. Breath-actuated nebulizers are vented with a one-way valve in the mouthpiece or mask, reducing the loss of continuous aerosol to atmosphere, increasing inhaled dose marginally over simple SVNs. For younger patients, the use of spacers or valved holding chambers may maximize benefit of the pMDI. Some metered dose inhalers are triggered with the negative pressure of inhalation. Most nebulizers and inhalers use a mouthpiece to interface with the patient.
Intestinal Bacterial Translocation Contributes to Diabetic Kidney Disease (2022)

Impaired MAVS signaling both in the kidney and intestine contributes to the disrupted homeostasis, leading to diabetic kidney disease progression. Controlling intestinal homeostasis may offer a novel therapeutic approach for this condition.
The future is now: single-cell genomics of bacteria and archaea (2013)

Interest in the expanding catalog of uncultivated microorganisms, increasing recognition of heterogeneity among seemingly similar cells, and technological advances in whole-genome amplification and single-cell manipulation are driving considerable progress in single-cell genomics. Here, the spectrum of applications for single-cell genomics, key advances in the development of the field, and emerging methodology for single-cell genome sequencing are reviewed by example with attention to the diversity of approaches and their unique characteristics. Experimental strategies transcending specific methodologies are identified and organized as a road map for future studies in single-cell genomics of environmental microorganisms. Over the next decade, increasingly powerful tools for single-cell genome sequencing and analysis will play key roles in accessing the genomes of uncultivated organisms, determining the basis of microbial community functions, and fundamental aspects of microbial population biology.
An Empirical Study of Factors Affecting Language-Independent Models (2022)

Scaling existing applications and solutions to multiple human languages has traditionally proven to be difficult, mainly due to the language-dependent nature of preprocessing and feature engineering techniques employed in traditional approaches. In this work, we empirically investigate the factors affecting language-independent models built with multilingual representations, including task type, language set and data resource.
CISPR 25 Radiated Emission Simulation and Measurement Correlation of an Automotive Reinforced Isolated Switch Driver (2022)

Applications of power electronics that integrate high-switching isolated gate drivers in switch mode power converters create excessive transient di/dt and dv/dt loops that exacerbate electromagnetic emissions. In this work, we developed a robust system-level coupled circuit-to-electromagnetic modeling and analysis methodology to predict the CISPR 25 radiated emission performance of a reinforced isolated switch driver during product development. The coupled method accurately captures the electromagnetic interactions between the nonlinear time-variant switchers and the system. Preliminary silicon validation measurements on an automotive high-switching isolated switch driver with an integrated power supply are presented to validate the integrity of the predictive modeling methodology. In an EMC pre-compliance lab, good correlations between modeling and measurements are achieved (i.e., within +/- 3dB for resonant peaks within the frequency band of 30MHz − 1GHz). The predictive EMC modeling methodology can be implemented to assess the performance of the initial silicon design during early IC development.
ChemInform Abstract: CYCLIC WATER SPLITTING INTO HYDROGEN AND OXYGEN BY VISIBLE LIGHT WITH COUPLED REDOX CATALYSTS (1979)

Abstract Bei Belichtung einer wäßrigen Lösung von 10 ‐4 mol/l Ru(bpy) 3 2+ und 2·10 ‐3 mol/l MV 2+ (N,N′‐Dimethylbipyridin‐Dikation) bei pH 4.7 in Gegenwart von RuO 2 (makrodispers) und kolloidalem Pt wird simultane Entwicklung von H 2 und O 2 beobachtet, und zwar ergeben 150 ml Lösung in 3 h mit einer 250 W‐Lampe 0.3 ml O 2 und 0.6 ml H 2 .
Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy (2020)

Although TTP importantly contributes to hepatic inflammation and cancer initiation, its loss with hepatocyte dedifferentiation fosters cancer cells migration and invasion. Loss of TTP may represent a clinically relevant biomarker of high-grade HCC associated with poor prognosis.