gebhart/patrepeval huggingface dataset:
HeapCraft: Quantifying and Predicting Collaboration in Minecraft (2015)

We present Heapcraft: an open-source suite of tools for monitoring and improving collaboration in Minecraft. At the core of our system is a data collection and analysis framework for recording gameplay. We collected over 3451 player-hours of game behavior from 908 different players, and performed a general study of online collaboration. To make our game analytics easily accessible, we developed interactive information visualization tools and an analysis framework for players, administrators, and researchers to explore graphs, maps and timelines of live server activity. As part of our research, we introduce the collaboration index, a metric which allows server administrators and researchers to quantify, predict, and improve collaboration on Minecraft servers. Our analysis reveals several possible predictors of collaboration which can be used to improve collaboration on Minecraft servers. Heapcraft is designed to be general, and has the potential to be used for other shared online virtual worlds.
Supplementary Table 8 from Pacritinib Combined with Sirolimus and Low-Dose Tacrolimus for GVHD Prevention after Allogeneic Hematopoietic Cell Transplantation: Preclinical and Phase I Trial Results (2023)

&lt;p&gt;The table shows the maximum chronic GVHD organ involvement and overall score per NIH Diagnosis and Staging Criteria through full extent of study follow up on the PAC/SIR/TAC phase I trial.&lt;/p&gt;
Catalytic Enantioselective Total Synthesis of (+)-Torrubiellone C (2011)

Silyl-protected (R)-methyl 2-(hydroxymethyl)butanoate was obtained by an enantioselective Ir-catalyzed hydrogenation in high yield and selectivity. Elaboration of this building block via Takai and Stille reactions gave a protected hydroxy polyene chain, which was coupled to a 5-hydroxyphenyl-4-hydroxy-2-pyridone derivative by a modified Horner-Wadsworth-Emmons reaction. Deprotection gave synthetic (+)-torrubiellone C, which led to the assignment of the configuration of the natural product as (R).
A Sonic Hedgehog (SH) Fusion Protein Corrects Multifocal Defects In Experimental Diabetic Neuropathy (2000)

Diabetic neuropathy develops from defective interactions between nerve axons and other cells in the endoneurium; such interactions are influenced in development by hedgehog proteins. This study explored the possibility that this might be maintained in the adult and form a basis for therapy in diabetic neuropathies. Streptozotocin‐diabetic rats were treated (final 5 weeks of 10 weeks diabetes) with a SH‐IgG fusion protein (either 0.3mg/kg or 3.0mg/kg s.c. 3 times per week); control diabetic and non‐diabetic rats received vehicle. Conduction velocity (MNCV, SNCV) data and sciatic nerve levels of nerve growth factor (NGF) and neuropeptide Y (NPY) are presented below. Diabetes caused significant (p &lt; 0.05 by ANOVA with SNK tests) reductions in all variables and treatment with SH‐IgG either attenuated or prevented (p &lt; 0.05) these reductions. Since it is well‐established that the conduction deficits are unrelated to neurotrophic deficits (NGF depletion) and that NPY depletion derives from a neurotrophic defect distinct from NGF, this treatment clearly acts at multiple components of the aetiology of diabetic neuropathy.
‘The future rests with the Free Churches’ (2015)

Abstract This chapter discusses how faltering church growth led to church union and the successful revival movement in Wales in the early twentieth century. Between 1900 and 1906, the combined membership of the five main Methodist denominations — Wesleyans, New Connexion, Primitive Methodist, Bible Christian, and United Free Methodist — and of the Baptists and Congregationalists rose by 10.6 per cent or 129,475. Total Free Church membership in England and Wales rose by 13.17 per cent from 1,911,924 in 1899 to 2,201,848 in 1906. By that latter date, Free Church membership in England and Wales exceeded the number of Anglican Easter communicants by nearly 100,000.
BRDF Error Analysis (1990)

A Bidirectional reflectance distribution function (BRDF) error analysis is given. Errors in measuring each of the components of BRDF are analyzed and a total RMS error calculation is given. A computerized error analysis allows each of the terms to be tested for their effect on the total error. This shows that different error mechanisms contribute in different measurement regimes.
Spontaneous Self‐Folding in Confined Ultrathin Polymer Gels (2010)

The formation of high-aspect folded structures with uniform feature sizes in responsive gel films are described. The folding patterns observed here in ultrathin films (20–100 nm) are strikingly different compared to the smooth sinusoidal buckling and cusp-shaped singularities observed earlier in relatively thick (a few tens of micrometers to a few millimeters) and stiffer films. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Synonymous Deoptimization of Foot-and-Mouth Disease Virus Causes Attenuation In Vivo while Inducing a Strong Neutralizing Antibody Response (2015)

Foot-and-mouth disease (FMD) is one of the most feared viral diseases that can affect livestock. Although this disease appeared to be contained in developed nations by the end of the last century, recent outbreaks in Europe, Japan, Taiwan, South Korea, etc., have demonstrated that infection can spread rapidly, causing devastating economic and social consequences. The Global Foot-and-Mouth Disease Research Alliance (GFRA), an international organization launched in 2003, has set as part of their five main goals the development of next-generation control measures and strategies, including improved vaccines and biotherapeutics. Our work demonstrates that newly developed codon pair bias deoptimization technologies can be applied to FMD virus to obtain attenuated strains with potential for further development as novel live attenuated vaccine candidates that may rapidly control disease without reverting to virulence.
‘Giese-type’ radical addition reactions to an acceptor that functions by a unimolecular chain transfer reaction of a silicon hydride (1995)

D. P. Curran and J. Xu, J. Chem. Soc., Perkin Trans. 1, 1995, 3061 DOI: 10.1039/P19950003061
Mineral deposition and vascular invasion of hydroxyapatite reinforced collagen scaffolds seeded with human adipose-derived stem cells (2019)

Collagen-based scaffolds reinforced with hydroxyapatite (HA) are an attractive choice for bone tissue engineering because their composition mimics that of bone. We previously reported the development of compression-molded collagen-HA scaffolds that exhibited high porosity, interconnected pores, and mechanical properties that were well-suited for surgical handling and fixation. The objective of this study was to investigate these novel collagen-HA scaffolds in combination with human adipose-derived stem cells (hASCs) as a template for bone formation in a subcutaneous athymic mouse model. Collagen-HA scaffolds and collagen-only scaffolds were fabricated as previously described, and a clinically approved bone void filler was used as a control for the material. Constructs were seeded with hASCs and were pre-treated with either control or osteogenic media. A cell-free group was also included. Scaffolds were implanted subcutaneously in the backs of athymic nude mice for 8 weeks. Mineral deposition was quantified via micro-computed tomography. Histological and immunofluorescence images of the explants were used to analyze their vascular invasion, remodeling and cellularity. Cell-free collagen-HA scaffolds and those that were pre-seeded with osteogenically differentiated hASCs supported mineral deposition and vascular invasion at comparable rates, while cell-seeded constructs treated with the control medium showed lower mineralization after implantation. HA-reinforcement allowed collagen constructs to maintain their shape, provided improved cell-tissue-scaffold integration, and resulted in a more organized tissue when pre-treated in an osteogenic medium. Scaffold type and pre-treatment also determined osteoclast activity and therefore potential remodeling of the constructs. The results of this study cumulatively indicate that treatment medium and scaffold composition direct mineralization and angiogenic tissue formation in an ectopic model. The data suggest that it may be necessary to match the scaffold with a particular cell type and cell-specific pre-treatment to achieve optimal bone formation.
Morphine effects within the rodent anterior cingulate cortex and rostral ventromedial medulla reveal separable modulation of affective and sensory qualities of acute or chronic pain (2018)

Modulation of pain may result from engagement of opioid receptors in multiple brain regions. Whether sensory and affective qualities of pain are differentially affected by brain opioid receptor circuits remains unclear. We previously reported that opioid actions within the rostral anterior cingulate cortex (ACC) produce selective modulation of affective qualities of neuropathic pain in rodents, but whether such effects may occur in other areas of the ACC is not known. Here, morphine was microinjected into 3 regions of the ACC or into the rostral ventromedial medulla (RVM), and pain behaviors in naive, sham, or spinal nerve ligated (SNL) rats were evaluated. In naive animals, the tail-flick response was inhibited by RVM, but not ACC, morphine. Anterior cingulate cortex morphine did not affect tactile allodynia (the von Frey test) or mechanical (Randall-Selitto) or thermal (Hargreaves) hyperalgesia in spinal nerve ligated rats. In contrary, RVM morphine reduced tactile allodynia and produced both antihyperalgesic and analgesic effects against mechanical and thermal stimuli as well as conditioned place preference selectively in nerve-injured rats. Within the RVM, opioids inhibit nociceptive transmission reflected in both withdrawal thresholds and affective pain behaviors. Activation of mu opioid receptors within specific rostral ACC circuits, however, selectively modulates affective dimensions of ongoing pain without altering withdrawal behaviors. These data suggest that RVM and ACC opioid circuits differentially modulate sensory and affective qualities of pain, allowing for optimal behaviors that promote escape and survival. Targeting specific ACC opioid circuits may allow for treatment of chronic pain while preserving the physiological function of acute pain.
Sexual Dimorphism in obsessive-compulsive disorder (2004)

"Sexual Dimorphism in obsessive-compulsive disorder." The World Journal of Biological Psychiatry, 5(4), p. 235
Capacity Planning for Dynamic Inter-Data Center Networking via Erlang Modeling (2013)

Data center virtualization and cloud service delivery models are driving the need for Network-as-a-Service offerings. This paper proposes a method for dimensioning networks for such services via Erlang modeling. Dynamic service adjustment and network orchestration are shown to achieve a major reduction in transport capacity requirements.
Novel duplex vapor-electrochemical method for silicon solar cells. Quarterly progress report No. 14, May 1-July 31, 1979 (1979)

Current work on the reaction between gaseous SiF/sub 4/ and solid Na has proceeded with the following objectives: (1) obtain data needed for plant design by scaling up the reaction to produce greater amounts of reaction product; (2) increase reaction rate and overall Si production rate; (3) increase the efficiency of the reaction so that less unreacted Na and less Na/sub 2/SiF/sub 6/ are produced; and (4) produce large amounts of reaction product for use in studies of Si recovery by melt separation. The SiF/sub 4/-Na reaction system has been scaled up to a reactor i.d., of 13 cm; the capacity of the Na chip feeder has also been increased. The system can now produce 5-kg batches of reaction product (mixed Si and NaF) at a production rate of 1.2 kg Si per hour. The melt-separation system has been modified to routinely melt 5-kg batches of mixed reaction product fed in a continuous mode at a production rate of 0.5 kg Si per hour. Support studies of Si coalescence show NaOH may be added to the NaF melt in amounts up to 5 wt % before there is any tendency for the Si to form large drops rather than a single pool. (WHK)
Optical transceivers using heterogeneous integration (2015)

The heterogeneous integration of InP into a silicon photonics platform enables the integration of diverse photonic elements in a cost-effective manufacturing process that fundamentally changes how photonic transceivers can be pack aged and integrated in to systems. This paper describes Aurrion's technology and provides some recent experimental results at the component and system level.
MIMO radar for sense and avoid for UAV (2010)

UAV are easily deployable platforms. Up to now they carry payloads (surveillance, combat) for military purposes in crisis or war time. For training, UAV are flown in special areas attributed in a limited space and a limited time slot. In the future, UAV will also be used for civilian tasks. For these reasons, UAV will have to be inserted in the general Air traffic and “Sense and Avoid” systems will be mandatory. Among the possible sensors, the radar is the most pertinent one: it is “all-weather” and provides accurate range, direction and closing speed. In this paper, a low cost solution based on the coherent “MIMO” principles is described. This solution allows the location of the radar within the UAV airframe without any moving parts, hence provides a high reliability level. The rationale of the proposed architecture is explained, then the enabling technologies and related waveforms are described.
Optimized T1-MPRAGE Sequence for Better Visualization of Spinal Cord Multiple Sclerosis Lesions at 3T (2013)

The optimized T1-MPRAGE sequence described here improves the reliability of lesion visualization and estimation of lesion burden, especially when used in conjunction with other well-established clinical sequences.
Robust Nonspiro‐Based Hole Conductors for High‐Efficiency Perovskite Solar Cells (2022)

Abstract Despite considerable development in performance, both poor operational stability and high costs associated with hole conductors such as 2,2′,7,7′‐tetrakis[ N , N ‐di(4‐methoxyphenyl)amino]‐9,9′‐spirobifluorene (spiro‐OMeTAD) and Poly[bis(4‐phenyl)(2,4,6‐trimethylphenyl)amine (PTAA) of perovskite solar cells (PSCs) need to be addressed by the research community. Here, two nonspiro hole transporting materials (HTMs), namely HTM‐1 and HTM‐2 , are designed and straightforwardly synthesized exhibiting remarkable electrochemical properties and hole mobilities. In particular, the PSC based on the methoxy derivative ( HTM‐2) exhibits a remarkable efficiency of 21.2% (stabilized efficiency of 20.8%), which is superior to the benchmark HTM spiro‐OMeTAD (stabilized efficiency of 20.4%). These results establish that the molecular design is effective in improving the performance of PSCs. Importantly, these two HTMs show admissible long‐term stability under different harsh conditions such as thermal stress up to 85 °C, high humidity level of 60% ± 10%, and continuous illumination over 1000 h. These insights allow correlating the impact of molecular design on optoelectronic properties of nonspiro‐based hole conductors with the overall device performance.
Pre-diabetes is associated with attenuation rather than volume of epicardial adipose tissue on computed tomography (2023)

The volume of epicardial adipose tissue (EATV) is increased in type-2 diabetes (T2D), while its attenuation (EATA) appears to be decreased. Similar patterns have been suggested in pre-diabetes, but data is scarce. In both pre-diabetes and T2D, any independent role of EATV and EATA in disease development remains to be proven, a task complicated by their substantial co-variation with other anthropometrics, e.g. BMI, waist circumference, and abdominal visceral adipose tissue (VAT). EATV and EATA was quantified in computed tomography (CT) images in a population study (n = 1948) using an automatic technique. Data was available on BMI, waist circumference, abdominal visceral adipose tissue (VAT) area, insulin resistance (IR) and glucose tolerance, the latter ranging from normal (NGT), over pre-diabetes (impaired fasting glucose [IFG, n = 414] impaired glucose tolerance [IGT, n = 321] and their combination [CGI, n = 128]), to T2D. EATV was increased in pre-diabetes, T2D and IR in univariable analyses and when adjusting for BMI, however not when adjusting for waist or VAT. EATA was reduced in pre-diabetes, T2D and IR in univariable analyses and when adjusting for BMI and waist, however not when adjusting for VAT. Adjustment for other co-variates had little influence on the results. In conclusion, EATV is increased and EATA reduced in pre-diabetes, T2D and IR, however, significant co-variation with other anthropometrics, especially VAT, obscures their function in disease development. The current results do not exclude a pathophysiological role of epicardial fat, but future studies need to adjust for anthropometrics, or focus on the microenvironment within the pericardial sac.
Photophysics, photochemistry, and theoretical calculations of some benz[a]anthracene-3,4-diones and their significance (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotophysics, photochemistry, and theoretical calculations of some benz[a]anthracene-3,4-diones and their significanceRalph S. Becker, L. V. Natarajan, Christian. Lenoble, and Ronald G. HarveyCite this: J. Am. Chem. Soc. 1988, 110, 21, 7163–7167Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://doi.org/10.1021/ja00229a034Request reuse permissionsArticle Views104Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (631 KB) Get e-Alertsclose Get e-Alerts
Adaptive Force Control for Unknown Environment Using Sliding Mode Controller with Variable Hyperplane (2003)

In this paper, a new type of sliding mode controller with gain-scheduled variable hyper plane for position and force control is presented. In this controller, the hyper plane in the sliding mode controller is continuously adjusted according to the environmental stiffness identified in real time. This controller is applied for force control using a one-degree-of-freedom manipulator system, and the performance of this controller is verified for both simulation and experiments.
Localized Quantum Walks in Quasiperiodic Photonics Lattices (2022)

Localized quantum walks are theoretically investigated in new class of quasiperiodic photonics lattices. Theoretical results have been validated quantitatively by experiments of quantum walks in Fibonacci multicore fibers.
Integration of Mid-Infrared Light Sources on Silicon-Based Waveguide Platforms in 3.5–4.7 μm Wavelength Range (2019)

Mid-infrared light sources are attracting attention for use in spectroscopic sensing, thermal imaging, and infrared countermeasures. Integration of these sources on Si-based waveguides allows for more functional and complex photonic circuits to be integrated on a single chip. This paper focuses on the key aspects of this integrated platform. The operation of silicon-on-insulator waveguides beyond 4.0 μm wavelength with increasing waveguide core thickness is discussed, and the effects of various cladding materials on waveguide propagation loss is demonstrated. Low loss waveguides and Mach-Zehnder interferometers in Ge-on-Si waveguide platform are discussed and beam combiners in the form of arrayed waveguide gratings are demonstrated in both the platforms. Interband cascade lasers are integrated on silicon-on-insulator waveguides with direct bonding to realize Fabry-Perot lasers. Power scaling of integrated lasers is validated by integrating quantum cascade lasers with silicon-on-insulator beam combiners. Results for the first integrated Fabry-Perot quantum cascade lasers on Ge-on-Si waveguides are discussed, together with the potential use of these waveguides to provide a better heat sink for integrated mid-infrared light sources.
The anatomy of the register file in a multiscalar processor (2005)

This paper presents the operation of the register file in the multiscalar architecture. The register file provides the appearance of a logically centralized register file, yet is implemented as physically decentralized register files, queues, and control logic in a multiscalar processor. We address the key issues of storage, communication, and synchronization required for a successful design and discuss the complications that arise in the face of speculation. In particular, the hardware required to implement the register file is detailed, and software support to streamline the operation of the register file is described. Illustrative examples detailing important aspects of the operation of the register file and an evaluation of its effectiveness are provided.
Les vecteurs viraux : outils modernes de vaccination (2008)

Les vaccins destinés aux animaux appartiennent à deux grandes catégories : les vaccins à agents vivants, et ceux à agents inertes. Depuis quelques années, dans chacune de ces catégories, les innovations technologiques ont considérablement amélioré et diversifié les stratégies vaccinales disponibles en fonction des contraintes liées à des préoccupations tant d’innocuité, que d’efficacité ou encore de nature économique. C’est dans ce cadre que l’INRA a depuis de nombreuses années orienté les efforts de recherche vers l’élaboration de nouveaux vaccins s’appuyant sur la mise au point de vecteurs viraux adaptés à diverses espèces animales et susceptibles de répondre aux exigences des filières animales. Dans cette revue, nous décrivons ainsi les principes d’obtention et le développement de vecteurs vaccinaux fondés sur l’emploi de poxvirus animaux à spectre d’hôte étroit (virus myxomateux), d’adenovirus humains ou animaux défectifs (c’est-à-dire ayant perdu toute capacité à se multiplier chez l’hôte) ainsi que de rhabdovirus de poissons modifiés par génétique inverse. Des exemples d’application de vaccination non seulement contre des maladies animales d’intérêt économique, mais aussi dans le cadre de modèles de pathologie comparée permettent d’illustrer le potentiel indiscutable de ces vecteurs viraux et d’envisager leur emploi pour le contrôle de maladies animales émergentes ou réémergentes en Europe.
Autofluorescence Imaging Resolves Early Cancer Treatment Response In Vivo (2013)

NADH and FAD auto-fluorescence intensity and lifetime imaging are used to monitor breast cancer metabolism. In vivo imaging of xenograft tumors revealed metabolic differences in responsive but not resistant tumors treated with trastuzumab at earlier time points than FDG-PET.
Conception d'une Antenne de Tag RFID UHF Passif (2007)

International audience