gebhart/patrepeval huggingface dataset:
Patient specific characteristics associated with T-cell expansion for HER2/neu vaccine-primed autologous adoptive T-cell therapy. (2018)

e15041 Background: Adoptive T-cell therapy (ACT) using tumor infiltrating lymphocytes (TIL) has shown significant response rates for metastatic melanoma. The need to harvest TIL from a visceral metastatic source for ACT has prevented its further application to other types of cancers. Two prior Phase I/II trials from our group demonstrated the feasibility of expanding and infusing autologous HER2 specific T cells from peripheral blood into advanced HER2+ breast cancer patients who received HER2 vaccination. Given the resource-intensive nature of ex-vivo T cell culture, determining patient specific characteristics predictive of favorable T-cell expansion would allow more optimal patient selection for ACT clinical trials. Methods: Under IRB approved protocols, we collected patient demographics, prior cancer therapies, baseline cell counts, and pathology data from our prior ACT trials in advanced HER2+ breast cancer. Cell expansion was calculated by comparing fold expansion after 24 days of culture from baseline T-cell counts. Pearson’s correlation test, t-test, and ANOVA were used for statistical analysis. GraphPad 7.04 was used for graphing. Results: Retrospective analysis of 26 HER2+ metastatic breast cancer patients who received ACT revealed a median age of 53 years (range 32 – 71). Most patients (16/26) had hormone receptor positive disease. The median cell fold expansion achieved was 7.4 (0.03 – 17.4). Age is negatively correlated with cell fold expansion (*p = 0.003) with a correlation coefficient of -0.56. Baseline lymphocyte count is correlated with cell fold expansion (*p = 0.04) with a correlation coefficient of +0.4. Neither HER2 (p = 0.61) nor hormone receptor status (p = 0.30) have significant correlation with cell fold expansion. Our group previously reported that magnitude of HER2-specific immunity after active immunization influences ex-vivo expansion, though current analysis showed no statistically significant association between timing of vaccine administration and cell fold expansion (p = 0.68). Conclusions: Criteria including age and baseline lymphocyte count may help guide patient selection and treatment prioritization for future ACT clinical trials.
Corroboration of Theory for H + D2 → D + HD (v′ = 3, j′ = 0) Reactive Scattering Dynamics (2008)

The differential cross section (DCS) for the reaction H + D2 --> D + HD (v' = 3, j' = 0) exhibits particularly rich dynamics; in addition to the expected direct recoil backscattering feature, a surprising time-delayed forward scattering feature appears that has been attributed to glory scattering arising from nearside and farside interference. This fact leads to a complex DCS that depends strongly on the collision energy. Its accurate calculation requires a fully quantum mechanical (QM) treatment. We report improved measurements of this DCS over the collision energy range 1.55 < or = E(coll) < or = 1.82 eV. Previous measurements using the core extraction method, while generally in agreement with theory, lacked sufficient resolution to capture all of the noteworthy behavior of the system; in the present work, we use ion imaging to observe many previously unresolved features of the DCS, particularly in the forward-scattered region. Agreement with QM calculations is found at all collision energies, reconciling an earlier discrepancy between experiment and theory near E(coll) = 1.54 eV.
ChemInform Abstract: The Importance of the Cycloaracylation Process for the Synthesis of Modern Fluoroquinolones (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Evolution and Kinetics of Volatile Organic Compounds Generated during Low-Temperature Polymer Degradation (2002)

A method using direct flame ionization detector (FID) measurement was developed to study total volatile organic compound (VOC) emissions during thermal degradation of polymers. This method was used to estimate organic emissions from different polymers, such as low-density polyethylene (PE), polypropylene (PP), polyethylene terephthalate (PET), and commingled postconsumer streams, such as recycled carpet residue and auto shredder residue (ASR). The effects of process parameters, such as temperature, heating rate, and residence time, were also studied. Significant VOC emissions were observed at normal processing temperatures, particularly from recycled polymers. Each polymer showed a distinct evolution pattern during its thermal degradation. The kinetics of VOC emissions were also studied using a nonisothermal technique. The kinetic parameters were in agreement with data from the literature.
Multistep fabrication of self-assembled unstrained quantum dashes (2006)

We describe a technique for molecular-beam-epitaxy-based fabrication of unstrained quantum dashes with AlxInyGa1−x−yAs alloys lattice matched to InP substrates. Templates for lattice-matched quantum dash growth are obtained by combining molecular beam epitaxy with in situ etching by arsenic bromide. A seed layer of strained self-assembled InAs quantum dashes is converted into nanotrench templates through overgrowth followed by strain-enhanced etching. We have explored limitations on the accessible range of alloy compositions imposed by the etch process and found that strain-induced etching is limited to compounds with low Al content. Nanotrench templates can be filled with lattice-matched alloys of varied compositions to define barriers and quantum wires that could lead to optoelectronic devices in a spectral range around 1.5μm.
Autocrine regulation of early embryonic development by the artemin‐GFRA3 (GDNF family receptor‐alpha 3) signaling system in mice (2009)

Development of early embryos is regulated by autocrine/paracrine factors. Analyzing the expression of polypeptide ligand–receptor pairs using DNA microarray datasets, we identified transcripts for artemin, a member of the GDNF (glial cell line‐derived neurotrophic factor) family, its receptor GFRA3 (GDNF family receptor‐alpha 3) and coreceptor RET. Here we report an autocrine/paracrine role of the artemin‐GFRA3 signaling system in regulating early embryonic development and apoptosis. Possible involvement of the MAP kinase signaling pathway was also demonstrated. The genome‐wide survey of ligand–receptor pairs and early embryo cultures provided a better understanding of autocrine/paracrine embryonic factors important for optimal blastocyst development.
Horizontal Disparity Pooling (1996)

Vertical magnification in one eye causes a frontoparallel surface to appear slanted about a vertical axis. Stenton, Frisby, and Mayhew [1984 Nature (London)309 622 – 623] showed using a dot display that, for mixtures of dots drawn from two populations of vertical magnification, the amount of horizontal magnification needed to null the perceive slant varies monotonically and nearly linearly with the mixture. We find a similar, but weaker, relationship for mixtures of horizontal magnification. In one experiment, a horizontal row of dots (containing no vertical disparity) was used to measure the local horizontal magnification needed to null the slant-biasing effect of a background which consisted of a pair of transparent planes made up of dots from two populations of horizontal magnification. The nulling magnification for the dot row was generally a monotonic function of the ratio of the number of dots from the two populations. In a second experiment, observers added horizontal disparity to the biplanar display itself until one plane appeared frontoparallel. The nulling horizontal magnification was again a monotonic function of the ratio of the number of dots from the two populations. We conclude that stereoscopic slant perception is influenced by pooling both of vertical and of horizontal magnifications within a stereoscopic image.
Exploratory research on impact of different data multiplexing schemes on activity recovery in cerebral SPECT imaging with AdaptiSPECT-C multi-pinhole brain-dedicated scanner (2020)

315 Objectives: SPECT can image a radiopharmaceutical distribution in brain according to cerebral perfusion, neurotransmitter, or cell density and therefore has many clinical applications [1]. We are developing a multi-detector multi-pinhole brain-dedicated SPECT scanner - AdaptiSPECT-C. Our selectable pinhole module technology [2] is used to adapt the collimator configuration such that each pinhole can be closed or open and image with a selectable aperture size. In this work, we explored the effects of 3 data acquisition (DAcq) schemes with different amounts of projection data overlap (i.e. multiplexing (MUX)) on activity recovery in brain perfusion imaging. Methods: The prototype design used in this work for AdaptiSPECT-C consists of 25 8” square detectors arranged in a truncated sphere with 3 rings of 10, 10, and 5 detector heads along caudal-cranial direction. Each detector is coupled with a 5-pinhole collimator consisting of one central and 4 diagonal pinholes of 2.5 mm diameter. We simulated 3 DAcq schemes as follows. Scheme #1 has 3 temporal frames: in the 1st frame, only the 1st pairs of the diagonal apertures are open; in the 2nd frame, only the 2nd pairs of the diagonal apertures are open; and in the 3rd frame, only the central apertures are open. In scheme #2, all apertures are open while in scheme #3, the 4 diagonal apertures are open, and the central apertures are not used. The digital XCAT phantom [3] was modified to simulate a brain perfusion distribution for the head size of 99th percentile male to investigate the near worst case in terms of MUX. Simulation and image reconstruction were performed by our generalizable multi-pinhole SPECT simulation and reconstruction software [4]. Defining the MUX% as the percentage of overlapped projection pixel counts to total acquired counts, schemes #1-3 have Conclusions: Based on a preliminary analysis of AR% of a brain perfusion phantom, we showed that in the current prototype design of AdaptiSPECT-C, opening 4 and 5 apertures per detector which allows high levels of MUX can be used to reconstruct images of AR% close to AR% in the gold standard image. Future investigations including simulating multiple noise realizations will be needed to do statistical analysis of quantification by different DAcq schemes. Research Support: National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Grant No R01 EB022521.
Shape from Texture and Shading with Wavelets (1999)

The observation of a photograph or a painting demonstrates our ability to recover a three-dimensional shape from a single image. Shape cues are provided by a combination of various types of information, including shading variations, effects of perspective and texture gradients. The goal pursued here is to answer the question: given the image of a textured surface, how is it possible to retrieve the surface depth ? Recent references to the shape from texture problem can be found in [2, 3, 8, 10, 13, 17, 18], and the shape from shading problem has been studied in [7, 12, 14, 15, 16].
Solvation of Lithium Hexamethyldisilazide by N,N-Dimethylethylenediamine:  Effects of Chelation on Competitive Solvation and Mixed Aggregation (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSolvation of Lithium Hexamethyldisilazide by N,N-Dimethylethylenediamine: Effects of Chelation on Competitive Solvation and Mixed AggregationBrett L. Lucht and David B. CollumView Author Information Department of Chemistry, Baker Laboratory Cornell University, Ithaca, New York 14853-1301 Cite this: J. Am. Chem. Soc. 1996, 118, 14, 3529–3530Publication Date (Web):April 10, 1996Publication History Received20 October 1995Published online10 April 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja953517xhttps://doi.org/10.1021/ja953517xrapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views412Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Amines,Mixtures,Monomers,Oligomers,Solvation Get e-Alerts
Total synthesis of prostaglandin-F2α, and the 9-O-benzyl derivatives of prostaglandins-F2α, -F1α, -D2, and -D1 (1981)

As an extension of the method whereby prostaglandin-F2α may be prepared by homoconjugate addition of an organocuprate reagent to the 3-endo-silyloxytricyclo[3.2.0.0.2,7]heptan-6-one (3), 3-endo-benzyloxytricyclo-[3.2.0.02,7]heptan-6-one (4) has been used to give the prostaglandin intermediate (14), in which the three hydroxy-functions at C-9, C-11, and C-15 are fully differentiated. Unmasking of the C-9 hydroxy-group gives the 15-silylated PG–F2α(15). The novel 9-O-benzyl derivatives of prostaglandin 5-F2α, -F1α, -D2, and -D1 were also prepared from (14) as possible antagonists of the natural compounds.
Fabrication of Hollow Polymeric Microstructures for Shear‐Protecting Cell‐Containers (2008)

A simple soft lithographic method is presented for generating hollow polymeric microstructures. The bottle-shaped cell containers allow for stable, non-invasive microenvironments for docked cells and could be applied to high-throughput analysis of cells under different shear conditions.
When drug nanocarriers miss their target: extracellular diffusion and cell uptake are not enough to be effective (2021)

Biocompatible nanoscale iron carboxylate metal-organic frameworks (nanoMOFs) have already demonstrated their ability to efficiently deliver various therapeutic molecules. The versatility of the synthesis methods and functionalization strategies could further improve their drug carrier potential. However, in oncology, preclinical evaluation still suffers from the lack of relevant models able to mimic the heterogeneity and the microenvironment of human tumors. This may impact the significance of the preclinical data, hindering the clinical translation and drug development process. Motivated by this hurdle, a 3D lung tumor model is herein developed to investigate nanoMOFs, as bare nanoparticles or coated with polyethylene glycol. Loading with doxorubicin, as a model drug, enables the investigation of their penetration capacity and efficacy in the 3D tumor nodule. NanoMOFs carry a large cargo, can diffuse efficiently within the tumor and are capable of significant intracellular penetration. Nevertheless, they prove to be therapeutically ineffective because the loaded drug is sequestrated in the lysosomal compartment and does not reach the nucleus, the doxorubicin sub-cellular target. These results question the in vivo evaluation of these nanoMOFs and call for further optimization to achieve successful drug delivery.
MODULATION BY β‐ADRENORECEPTORS OF SPONTANEOUS CONTRACTIONS OF RAT URINARY BLADDER (1982)

1 Propranolol (0.1 mg/kg i.v.) but not metoprolol (0.2 mg/kg i.v.) pretreatment increased the spontaneous motility triggered by progressive filling of rat urinary bladder without a concomitant effect on bladder capacity, except at high filling volumes. Compared to controls, the spontaneous motility of urinary bladder in propranolol pretreated rats displayed a higher frequency, indicating the existence of a tonic sympathetic inhibition. 2 beta-adrenoreceptor stimulation by isoprenaline (0.1-10 microgram/kg i.v.) or terbutaline (0.1-1 mg/kg i.v.) in vivo produced a dose dependent inhibition of bladder spontaneous motility which was antagonized by propranolol (0.1 mg/kg i.v.) but not by metoprolol (0.2 mg/kg i.v.). Propranolol (0.2 mg/kg i.v.) pretreatment did not antagonize the inhibition of bladder motility produced by intravenous papaverine (0.5 mg/kg). 3 Propranolol (0.1 mg/kg i.v.) significantly antagonized the isoprenaline-induced tachycardia (beta 1 mediated) and fall in diastolic blood pressure (beta 2 mediated) while metoprolol (0.2 mg/kg i.v.) antagonism was confined to beta 1 mediated responses. 4 Isoprenaline (0.25-1.5 microM) inhibited in a concentration dependent manner field stimulation induced contractions of rat detrusor muscle strips as did tetrodotoxin (0.5 microM). Hexamethonium (50 microM) had no inhibitory effect. 5 Our in vivo findings support the view that beta 2-adrenoreceptors are responsible for modulating bladder motility mainly by suppressing the onset of spontaneous contractions.
Potential Anticancer Effects of Polyphenols from Chestnut Shell Extracts: Modulation of Cell Growth, and Cytokinomic and Metabolomic Profiles (2016)

In this study, a hydroalcoholic chestnut shell extract was characterized and tested on six different human cell lines. Gallic, ellagic, and syringic acids were the most abundant non-condensed compounds in the chestnut extract, as determined by high performance liquid chromatography (HPLC). Tannins were mainly represented by condensed monomeric units of epigallocatechin and catechin/epicatechin. After 48 h of treatment, only the human hepatoblastoma HepG2 cells reached an inhibition corresponding to IC<sub>50</sub> with an increase of apoptosis and mitochondrial depolarization. The cytokinome evaluation before and after treatment revealed that the vascular endothelial growth factor (VEGF) and the tumor necrosis factor (TNF)-α decreased after the treatment, suggesting a potential anti-angiogenic and anti-inflammatory effect of this extract. Moreover, the metabolome evaluation by ¹H-NMR evidenced that the polyphenols extracted from chestnut shell (PECS) treatment affected the levels of some amino acids and other metabolites. Overall, these data highlight the effects of biomolecules on cell proliferation, apoptosis, cell cycle and mitochondrial depolarization, and on cytokinomics and metabolomics profiles.
Supplementary table 7 from Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(−) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG (2023)

&lt;p&gt;Combined multivariate analyses of HPV16 DNA, cancer stem cell markers, hypoxia and additional prognostic factors for all patients (endpoint loco-regional control). HR = hazard ratio; 95% CI = 95 percent confidence interval; ECE = extracapsular extension.&lt;/p&gt;
Daytime Glibenclamide and Bedtime NPH Insulin Compared to Intensive Insulin Treatment in Secondary Sulphonylurea Failure: a 1-Year Follow-up (1996)

The aim of this study was to compare the metabolic effects of a combination of daytime glibenclamide and evening NPH insulin with intensive insulin treatment (rapid acting insulin before meals and NPH insulin at bedtime) in patients exhibiting secondary failure to sulphonylurea treatment. Thirty-nine mildly obese NIDDM patients (BMI 25.6 +/- 0.5) were randomized after 6 weeks of intensive insulin treatment to either a combination treatment (CT, n = 20) or continued intensive insulin treatment (IT, n = 19). There were no differences between the two groups in age, diabetes duration, BMI, HbA1c, or basal and glucagon stimulated C-peptide. The patients were followed for 1 year and the findings were analysed on an intent to treat basis. Two patients in the CT group were excluded after 2 and 6 months, respectively, due to unacceptably high postprandial glucose values. There was a significant difference in HbA1c between the CT and IT groups at 6 months (8.2 +/- 0.2, n = 19, vs 6.8 +/- 0.4%, n = 19, p < 0.001)), but not at 12 months (7.8 +/- 0.3, n = 18, vs 7.5 +/- 0.4%, n = 19). After the initial intensive insulin treatment, BMI was constant in the CT group but increased significantly at 6 and 12 months in the IT group. We conclude that both treatments are associated with a marked and long-term improvement of glycaemic control. The intensive insulin treatment leads to a more pronounced weight increase which in the long run might have negative effect on overall metabolic control. Therefore, the combination treatment together with intensified education and dietary advice should be regarded as the initial treatment of choice for oral agent failure in moderately obese NIDDM patients.
An overview of current issues in the uptake of atmospheric trace gases by aerosols and clouds (2010)

Abstract. A workshop was held in the framework of the ACCENT (Atmospheric Composition Change – a European Network) Joint Research Programme on "Aerosols" and the Programme on "Access to Laboratory Data". The aim of the workshop was to hold "Gordon Conference" type discussion covering accommodation and reactive uptake of water vapour and trace pollutant gases on condensed phase atmospheric materials. The scope was to review and define the current state of knowledge of accommodation coefficients for water vapour on water droplet and ice surfaces, and uptake of trace gas species on a variety of different surfaces characteristic of the atmospheric condensed phase particulate matter and cloud droplets. Twenty-six scientists participated in this meeting through presentations, discussions and the development of a consensus review. In this review we present an analysis of the state of knowledge on the thermal and mass accommodation coefficient for water vapour on aqueous droplets and ice and a survey of current state-of the-art of reactive uptake of trace gases on a range of liquid and solid atmospheric droplets and particles. The review recommends consistent definitions of the various parameters that are needed for quantitative representation of the range of gas/condensed surface kinetic processes important for the atmosphere and identifies topics that require additional research.
Search for anomalous production of prompt same-sign lepton pairs and pair-produced doubly charged Higgs bosons with s = 8 $$ \sqrt{s}=8 $$ TeV pp collisions using the ATLAS detector (2015)

A low-background inclusive search for new physics in events with same-sign dileptons is presented. The search uses proton-proton collisions corresponding to 20.3 fb -1 of integrated luminosity taken in 2012 at a centre-of-mass energy of 8 TeV with the ATLAS detector at the LHC. Pairs of isolated leptons with the same electric charge and large transverse momenta of the type e e , e , and are selected and their invariant mass distribution is examined. No excess of events above the expected level of Standard Model background is found. The results are used to set upper limits on the cross-sections for processes beyond the Standard Model. Limits are placed as a function of the dilepton invariant mass within a fiducial region corresponding to the signal event selection criteria. Exclusion limits are also derived for a specific model of doubly charged Higgs boson production.
Adaptive optics for high-resolution microscopy (2012)

Aberrations frequently affect image quality of microscopes, especially with thick tissue specimens. Adaptive optics can correct aberrations, providing high resolution and contrast images at depth. We describe new methods and applications of this technology.