gebhart/patrepeval huggingface dataset:
Methodology for assessment of inertial response from wind power plants (2012)

High wind power penetration levels result in additional requirements from wind power in order to improve frequency stability. Replacement of conventional power plants with wind power plants reduces the power system inertia due to the wind turbine technology. Consequently, the rate of change of frequency and the maximum frequency deviation increase after a disturbance such as generation loss, load increase, etc. Having no inherent inertial response, wind power plants need additional control concepts in order to provide an additional active power following a disturbance. Several control concepts have been implemented in the literature, but the assessment of these control concepts with respect to power system requirements has not been specified. In this paper, a methodology to assess the inertial response from wind power plants is proposed. Accordingly, the proposed methodology is applied to one of the inertial response control concepts from the literature.
Abstract 236: Vascular Smooth Muscle Cells Stimulate Re-endothelialization Through Protein Kinase C-delta-dependent Release Of CXCL7 and Recruitment of Circulating Angiogenic Cells (2015)

Objective: In response of injury, vascular smooth muscle cells (VSMCs) undergo proliferation, migration, as well as apoptosis. We have previously shown that gene transfer of a pro-apoptotic mediator protein kinase C-delta (PKCδ) reduces intimal hyperplasia. Subsequently, we showed that VSMCs are a rich source of chemokines. In this study, we explored whether VSMCs may play a role in regulation of re-endothelialization through PKCδ-dependent release of chemokines. Methods and Results: We constructed an adenovirus that expresses PKCδ under VSMC-specific SM22 promoter (AdPKCδ) and use it to drive PKCδ expression in VSMCs of injured rat carotid arteries. Compared to the empty vector (AdNull), AdPKCδ accelerated re-endothelialization, reflected by a larger area that was excluded of Evan’s blue (25.38±7.52% v.s 59.60±5.01%). Media conditioned by PKCδhigh VSMCs had no measurable effects on endothelial cell functions, including BrdU incorporation, transwell migration, scratch wound healing, and tube formation. Interestingly, PKCδhigh VSMCs conditioned media attracted circulating angiogenic cells (CACs), a population of cells that promote neovascularization via production of angiogenic factors. Using a PCR array analysis, we identified a group of PKCδ upregulated chemokines in VSMCs, including MCP-1, CXCL1, and CXCL7. Neutralizing CXCL7, but not MCP-1 or CXCL1, significantly blocked PKCδhigh VSMC conditioned media induced migration of CACs. In vivo, we observed more CD133+ (a marker of CACs) cells lined up to the lumen of PKCδhigh expressing vessels, while the number of CD133+ cells was comparable in the blood of AdPKCδ treated rats and AdNull treated rats. Immunofluorescence staining revealed that delivery of PKCδ gene increased CXCL7 expression in media VSMCs. Conclusions: Our data suggest that VSMCs stimulate re-endothelialization through PKCδ-dependent release of CXCL7 and recruitment of CACs.
8.1 A 93.8% Peak Efficiency, 5V-Input, 10A Max I<inf>LOAD</inf> Flying Capacitor Multilevel Converter in 22nm CMOS Featuring Wide Output Voltage Range and Flying Capacitor Precharging (2019)

Power delivery for compute SoCs has become a major challenge due to increasing current demands, shrinking form factors, as well as highly dynamic load patterns. Traditional inductive topologies like buck converters still require large inductances since switching frequencies cannot be increased without degrading efficiency. As a result, converter sizes are difficult to scale and transient responses are slow. On the other hand, switched capacitor converters (SCCs) are promising for small form factors and offer fast transient response since they do not require large inductors. However, SCCs can achieve high efficiency only at fixed conversion ratios, thus limiting their usage since a wide continuous range of input and output voltages are needed in SoC platforms. Hybrid converters offer the combined benefits of conventional buck and SC topologies [1]-[3]. They can provide superior power density and efficiency by reducing both inductance and capacitance requirements significantly. Since they use stacked low voltage transistors like SCCs, higher switching frequencies can be achieved without degrading efficiency. In addition, soft-charging of the flying capacitors through the inductor eliminates charge-sharing losses present in pure SCCs.
3D stacked embedded component system-in-package for wearable electronic devices (2017)

This paper discusses design, fabrication and characterization of a 3D stacked small form factor (SFF) system-in-packages (SiPs) suitable for wearable electronics systems. In order to achieve very small size SiP, two SFF multi-chip packages were designed and fabricated utilizing embedded wafer-level ball grid array (e-WLB) technology. The package consisted of six radio frequency (RF) and digital integrated circuits (ICs), and 24 passive components of varying sizes. 3-D stacked system in package was of size 6.0 × 5.5 × 1.9 mm and was 55% smaller than the same system fabricated using conventional printed circuit board technology. The measured results showed that system performance was on par with or better than the previous systems.
Integer Ambiguity Estimation for Satellite Navigation (2012)

Carrier phase measurements of pseudoranges often allow for millimeter precision. The periodic nature of the carrier phase, however, leads to integer ambiguities. These ambiguities need to be resolved for accurate positioning. Blewitt and Teunissen provide two methods for the associated estimation process. The present paper complements their work with an improved real-valued diagonalization of the ambiguity covariance matrix, and a functional determination of an integer decorrelation transformation. The proposed method achieves a similar performance as Teunissen's LAMBDA method-in terms of the probability of wrong fixing, but with a reduced complexity. Furthermore, it shows a slightly different path towards ambiguity resolution.
Development of energy-tunable positronium beams employing the photodetachment of positronium negative ions (2014)

Recent progress on the development of an energy-tunable positronium beam is reviewed. We describe experimental results for the efficient emission of positronium negative ions from alkali-metal coated tungsten surfaces. The ions generated using this technique have been accelerated by an electric field and photodetached in order to produce positronium beams with a hitherto unrealized energy range up to 1.9 keV.
TNF‐Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization (2021)

Nonalcoholic steatohepatitis (NASH) is a progressive, chronic liver disease worldwide which imposes a large economic burden on society. M1/M2 macrophage balance destruction and recruitment of mononuclear immune cells to the liver play critical roles in NASH. Several studies have shown that the expression of TNF-like ligand 1 aberrance (TL1A) increased in macrophages associated with many inflammatory diseases, for example, inflammatory bowel disease, primary biliary cholangitis, and liver fibrosis. One recent research showed that weight, abdominal adipose, and liver leptin, one of the critical fat cytokines, were reduced in <i>TL1A</i> knockout mice. However, the functional and molecular regulatory mechanisms of TL1A on macrophage polarization and recruitment in NASH have yet to be clarified. The authors found that high fructose high fat diet and methionine-choline deficiency diet induced the expression of TL1A in macrophages of liver tissue from murine NASH models. Myeloid-specific TL1A overexpressed mice showed exacerbated steatohepatitis with increased hepatic lipid accumulation, inflammation, liver injury, and apoptosis. M1 macrophages' infiltration and the production of proinflammatory and chemotactic cytokines increased in liver of NASH mouse models with myeloid-specific TL1A overexpressed. Furthermore, this paper revealed that bone marrow-derived macrophages and Kupffer cells with overexpression of TL1A exacerbated the lipid accumulation and expression of proinflammatory factors in the murine primary hepatocytes after free fatty acid treatment <i>in vitro</i>. In conclusion, TL1A-mediated M1-type macrophage polarization and recruitment into the liver promoted steatohepatitis in murine NASH.
NAKFI Smart Prosthetics: Exploring Assistive Devices for the Body and Mind (2007)

Prosthetics to replace impaired or absent body functions are clearly one the earliest examples of medical technology. Many might argue that true advances in prosthetic technologies, especially repl...
Establishing a base of trust with performance counters for enterprise workloads (2015)

Understanding the performance of large, complex enterprise-class applications is an important, yet nontrivial task. Methods using hardware performance counters, such as profiling through event-based sampling, are often favored over instrumentation for analyzing such large codes, but rarely provide good accuracy at the instruction level. This work evaluates the accuracy ofmultiple eventbased sampling techniques and quantifies the impact of a range of improvements suggested in recent years. The evaluation is performed on instances of three modern CPU architectures, using designated kernels and full applications. We conclude that precisely distributed events considerably improve accuracy, with further improvements possible when using Last Branch Records. We also present practical recommendations for hardware architects, tool developers and performance engineers, aimed at improving the quality of results.
Cardiac computed tomography-derived coronary artery volume to myocardial mass (2021)

In the absence of disease impacting the coronary arteries or myocardium, there exists a linear relationship between vessel volume and myocardial mass to ensure balanced distribution of blood supply. This balance may be disturbed in diseases of either the coronary artery tree, the myocardium, or both. However, in contemporary evaluation the coronary artery anatomy and myocardium are assessed separately. Recently the coronary lumen volume to myocardial mass ratio (V/M), measured noninvasively using coronary computed tomography angiography (CTCA), has emerged as an integrated measure of myocardial blood supply and demand in vivo. This has the potential to yield new insights into diseases where this balance is altered, thus impacting clinical diagnoses and management. In this review, we outline the scientific methodology underpinning CTCA-derived measurement of V/M. We describe recent studies describing alterations in V/M across a range of cardiovascular conditions, including coronary artery disease, cardiomyopathies and coronary microvascular dysfunction. Lastly, we highlight areas of unmet research need and future directions, where V/M may further enhance our understanding of the pathophysiology of cardiovascular disease.
A power efficient framing structure for a next generation mobile broadcast system (2011)

Excellent power efficiency on the physical layer is one of the key requirements for mobile data transmission systems. Besides increasing the life time of the battery, this also minimizes the implementation costs. This paper describes a flexible framing structure, which allows for decoupling of the bandwidth of the transmitted OFDM signal and the bandwidth used by the receiver. Instead of decoding signals across the whole transmission channel, the proposed receiver utilizes only a narrow bandwidth segment with a fixed OFDM sub-carrier spacing. Hence, a low power receiver architecture with reduced complexity can be obtained. The described framing concept was originally proposed for the use in DVB's next generation handheld broadcasting standard DVB-NGH. However, this concept is not limited to broadcasting, but can be used in point to-point systems. This paper shows simulation results that prove the performance of the proposed solution in mobile channels and analyzes its power reduction capabilities.
International Consortium for Health Outcomes Measurement (ICHOM): Standardized Patient-Centered Outcomes Measurement Set for Heart Failure Patients (2019)

Whereas multiple national, international, and trial registries for heart failure have been created, international standards for clinical assessment and outcome measurement do not currently exist. The working group's objective was to facilitate international comparison in heart failure care, using standardized parameters and meaningful patient-centered outcomes for research and quality of care assessments. The International Consortium for Health Outcomes Measurement recruited an international working group of clinical heart failure experts, researchers, and patient representatives to define a standard set of outcomes and risk-adjustment variables. This was designed to document, compare, and ultimately improve patient care outcomes in the heart failure population, with a focus on global feasibility and relevance. The working group employed a Delphi process, patient focus groups, online patient surveys, and multiple systematic publications searches. The process occurred over 10 months, employing 7 international teleconferences. A 17-item set has been established, addressing selected functional, psychosocial, burden of care, and survival outcome domains. These measures were designed to include all patients with heart failure, whether entered at first presentation or subsequent decompensation, excluding cardiogenic shock. Sources include clinician report, administrative data, and validated patient-reported outcome measurement tools: the Kansas City Cardiomyopathy Questionnaire; the Patient Health Questionnaire-2; and the Patient-Reported Outcomes Measurement Information System. Recommended data included those to support risk adjustment and benchmarking across providers and regions. The International Consortium for Health Outcomes Measurement developed a dataset designed to capture, compare, and improve care for heart failure, with feasibility and relevance for patients and clinicians worldwide.
Suppl. Figure S6 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma (2023)

&lt;p&gt;S6: Correlation analysis between MEKi and ROS.&lt;/p&gt;
Study of atmospheric CH4 mole fractions at three WMO/GAW stations in China (2013)

Abstract Atmospheric CH 4 mole fractions were continuously measured from 2009 to 2011 at three WMO/GAW stations in China (Lin'an, LAN; Longfengshan, LFS; and Waliguan, WLG) using three Cavity Ring Down Spectroscopy instruments. LAN and LFS are GAW regional measurement stations. LAN is located in China's most economically developed region, and LFS is in a rice production area (planting area &gt; 40,000 km 2 ). WLG is a global measurement station in remote northwest China. At LAN, high methane mole fractions are observed in all seasons. Surface winds from the northeast enhance CH 4 values, with a maximum increase of 32 ± 15 ppb in summer. The peak to peak amplitude of the seasonal cycle is 77 ± 35 ppb. At LFS, the diurnal cycle amplitude is approximately constant throughout the year except summer, when a value of 196 ± 65 ppb is observed. CH 4 values at LFS reach their peak in July, which is different from seasonal variations typically observed in the northern hemisphere. CH 4 mole fractions at WLG show both the smallest values and the lowest variability. Maximum values occur during summer, which is different from other northern hemisphere WMO/GAW global stations. The seasonal cycle amplitude is 17 ± 11 ppb. The linear growth rates at LAN, LFS, and WLG are 8.0 ± 1.2, 7.9 ± 0.9, and 9.4 ± 0.2 ppb yr −1 , respectively, which are all larger than the global mean over the same 3 year period. Results from this study attempt to improve our basic understanding of observed atmospheric CH 4 in China.
Role of cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (mRCC). (2021)

4582 Background: The role of CN in mRCC was challenged by the results of the CARMENA trial in the targeted therapy (TT) era. We sought to evaluate the role of both upfront and deferred CN in pts receiving modern IO-based and TT regimens. Methods: Pts with synchronous mRCC who received systemic therapy (tx) for mRCC after 2011 were included from the de-identified nationwide Flatiron Health database. We evaluated 3 groups: systemic tx alone, systemic-&gt; CN, and CN-&gt; systemic tx. Overall survival (OS) was calculated from the time of initiation of first therapy – systemic or CN. Patient characteristics were compared using chi-squared tests or t-test. Weighted Kaplan-Meier curves, log-rank tests, and Cox proportional hazards regressions with time-varying covariates were used to assess the effect of tx on survival. Adjustment was conducted via inverse probability of treatment weighing based on the generalized propensity score, estimated via Bayesian Additive Regression Trees. Covariates in the model were age, gender, race, insurance at mRCC diagnosis, and IMDC risk group. Results: Of 1719 pts with mRCC, 972 (56.5%) received systemic tx alone, 605 (35.1%) received CN-&gt; systemic tx, and 142 (8.2%) received systemic-&gt;CN. 310 pts received IO or IO/IO, 123 pts received IO+TT and 1152 pts received only TT. The median follow-up was 37.1 months. In adjusted analyses using propensity score weighting and time-varying covariates, CN-&gt; systemic was significantly associated with improved OS compared with systemic tx alone (Table). When stratifying groups by type of systemic treatment (IO and TT), there was improvement of OS in the CN groups compared to systemic tx alone, although we lacked power to reach statistical significance. Among CN-treated patients, the order of systemic tx relative to CN did not change OS (hazard ratio [HR] = 1.00, 95% CI 0.76-1.32, p=0.96). Conclusions: Using a national, EHR-based cohort, which includes a large number of IO treated pts, our findings support an oncologic role for CN in select mRCC pts. The timing of CN, for pts who were able to receive both systemic therapy and CN, may not affect overall outcome. The associated improvement in survival of CN is seen in pts receiving IO and TKI based systemic tx.[Table: see text]
ChemInform Abstract: Organocatalytic Strategies for Enantioselective Metal‐Free Reductions (2014)

Abstract Review: 107 refs.
TGF-β and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3 (2008)

Expression of FOXP3, a potent gene-specific transcriptional repressor, in regulatory T cells is required to suppress autoreactive and alloreactive effector T cell function. Recent studies have shown that FOXP3 is an acetylated protein in a large nuclear complex and FOXP3 actively represses transcription by recruiting enzymatic corepressors, including histone modification enzymes. The mechanism by which extracellular stimuli regulate the FOXP3 complex ensemble is currently unknown. Although TGF-beta is known to induce murine FOXP3(+) Treg cells, TGF-beta in combination with IL-6 attenuates the induction of FOXP3 functional activities. Here we show that TCR stimuli and TGF-beta signals modulate the disposition of FOXP3 into different subnuclear compartments, leading to enhanced chromatin binding in human CD4(+)CD25(+) regulatory T cells. TGF-beta treatment increases the level of acetylated FOXP3 on chromatin and site-specific recruitment of FOXP3 on the human IL-2 promoter. However, the proinflammatory cytokine IL-6 down-regulates FOXP3 binding to chromatin in the presence of TGF-beta. Moreover, histone deacetylation inhibitor (HDACi) treatment abrogates the down-regulating effects of IL-6 and TGF-beta. These studies indicate that HDACi can enhance regulatory T cell function via promoting FOXP3 binding to chromatin even in a proinflammatory cellular microenvironment. Collectively, our data provide a framework of how different signals affect intranuclear redistribution, posttranslational modifications, and chromatin binding patterns of FOXP3.
Random walks with “back buttons” (extended abstract) (2000)

Article Free Access Share on Random walks with "back buttons" (extended abstract) Authors: Ronald Fagin IBM Almaden Research Center, 650 Harry Road, San Jose, CA IBM Almaden Research Center, 650 Harry Road, San Jose, CAView Profile , Anna R. Karlin Department of Computer Science, Box 352350, University of Washington, Seattle, WA Department of Computer Science, Box 352350, University of Washington, Seattle, WAView Profile , Jon Kleinberg Department of Computer Science, Cornell University, Ithaca, NY Department of Computer Science, Cornell University, Ithaca, NYView Profile , Prabhakar Raghavan IBM Almaden Research Center, 650 Harry Road, San Jose, CA IBM Almaden Research Center, 650 Harry Road, San Jose, CAView Profile , Sridhar Rajagopalan IBM Almaden Research Center, 650 Harry Road, San Jose, CA IBM Almaden Research Center, 650 Harry Road, San Jose, CAView Profile , Ronitt Rubinfeld NECI, 4 Independence Way, Princeton, NY NECI, 4 Independence Way, Princeton, NYView Profile , Madhu Sudan MIT Laboratory for Computer Science, 545 Technology Square NE43-307, Cambridge, MA MIT Laboratory for Computer Science, 545 Technology Square NE43-307, Cambridge, MAView Profile , Andrew Tomkins IBM Almaden Research Center, 650 Harry Road, San Jose, CA IBM Almaden Research Center, 650 Harry Road, San Jose, CAView Profile Authors Info & Claims STOC '00: Proceedings of the thirty-second annual ACM symposium on Theory of computingMay 2000 Pages 484–493https://doi.org/10.1145/335305.335362Published:01 May 2000Publication History 15citation507DownloadsMetricsTotal Citations15Total Downloads507Last 12 Months27Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF