gebhart/patrepeval huggingface dataset:
Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca–/– and Fancg–/– Mice by Intraoral Administration of GS-Nitroxide (JP4-039) (2018)

Squamous cell carcinomas of the head and neck are appearing with increased frequency in both marrow transplanted and non-transplanted Fanconi anemia (FA) patients. FA patients commonly display radiosensitivity of epithelial tissues, complicating effective radiotherapy. Fancd2<sup>-/-</sup> mice (C57BL/6J and 129/Sv background) demonstrate epithelial tissue sensitivity to single-fraction or fractionated irradiation to the head and neck and distant marrow suppression (abscopal effect), both ameliorated by intraoral administration of the mitochondrial-targeted antioxidant, GS-nitroxide, JP4-039. We now report that mice of two other FA genotypes, Fancg<sup>-/-</sup> (B6) and the most prevalent human genotype Fanca<sup>-/-</sup> (129/Sv), also demonstrate: 1. reduced longevity of hematopoiesis in long-term bone marrow cultures; 2. radiosensitivity of bone marrow stromal cell lines; and 3. head and neck radiation-induced severe mucositis and abscopal suppression of distant marrow hematopoiesis. Intraoral administration of JP4-039/F15, but not non-mitochondrial-targeted 4-amino-Tempo/F15 or F15 alone, prior to each radiation treatment ameliorated both local and abscopal radiation effects. Head and neck irradiated TGF-β-resistant SMAD3<sup>-/-</sup> (129/Sv) mice and double-knockout SMAD3<sup>-/-</sup> Fancd2<sup>-/-</sup> (129/Sv) mice treated daily with TGF-β receptor antagonist, LY364947, still displayed abscopal bone marrow suppression, implicating a non-TGF-β mechanism. Thus, amelioration of both local normal tissue radiosensitivity and distant marrow suppression by intraoral administration of JP4-039 in Fancg<sup>-/-</sup> and Fanca<sup>-/-</sup> mice supports a clinical trial of this locally administered normal tissue radioprotector and mitigator during head and neck irradiation in FA patients.
The Intercellular Signaling Activity of the Mycobacterium tuberculosis Chaperonin 60.1 Protein Resides in the Equatorial Domain (2005)

The major heat shock protein, chaperonin 60, has been established to have intercellular signaling activity in addition to its established protein-folding function. Mycobacterium tuberculosis is one of a small proportion of bacteria to encode two chaperonin 60 proteins. We have demonstrated that chaperonin 60.1 from this bacterium is a very active stimulator of human monocytes. To determine structure/function relationships of chaperonin 60.1 we have cloned and expressed the apical, equatorial, and intermediate domains of this protein. We have found that the signaling activity of M. tuberculosis chaperonin 60.1 resides in the equatorial domain. This activity of the recombinant equatorial domain was completely blocked by treating the protein with proteinase K, ruling out lipopolysaccharide contamination as the cause of the cell activation. Blockade of the activity of the equatorial domain by anti-CD14 monoclonal antibodies reveals that this domain activates monocytes by binding to CD14. Looking at the oligomeric state of the active proteins, using native gel electrophoresis and protein cross-linking we found that recombinant M. tuberculosis chaperonin 60.1 fails to form the prototypic tetradecameric structure of chaperonin 60 proteins under the conditions tested and only forms dimers. It is therefore concluded that the monocyte-stimulating activity of M. tuberculosis Cpn60.1 resides in the monomeric subunit and within this subunit the biological activity is due to the equatorial domain.
Hydrogen atoms inKH2PO4crystals (1998)

Hydrogen atoms have been produced at 77 K in single crystals of potassium dihydrogen phosphate (${\mathrm{KH}}_{2}{\mathrm{PO}}_{4}$ or KDP) using either 60-kV x rays or the fourth harmonic (266 nm) of a pulsed Nd:YAG (yttrium aluminum garnet) laser. The electron-paramagnetic-resonance spectrum from these hydrogen atoms exhibits a characteristic 500-G hyperfine splitting and is easily saturated with microwave power. These atoms occupy interstitial sites and are electron traps. The corresponding hole trap is the well-known $({\mathrm{HPO}}_{4}{)}^{\ensuremath{-}}$ hole center identified by its 31-G phosphorus hyperfine splitting. Both the hydrogen atoms and the hole centers thermally decay in the temperature range between 80 and 200 K. The observed displacement of protons by 266-nm photons provides direct evidence in support of the proton-transport mechanism recently proposed by Davis, Hughes, and Lee [Chem. Phys. Lett. 207, 540 (1993)] to explain laser-induced transient optical absorption at room temperature in KDP.
JV Task-Long-Kiln NOx Reduction Study (2008)

Field sampling was conducted by the Energy & Environmental Research Center at two Lafarge North America cement kiln locations in Canada. Emissions including SO{sub x}, NO{sub x}, and particulate were measured and reported at various locations throughout the kilns. At each site data were collected on two kilns during field sampling. However, only Kiln 1 at the Ravena site was utilized for modeling efforts. Experimental work was then conducted to estimate the effectiveness of various NO{sub x} control techniques on limiting both NO{sub x} and SO{sub x} emissions in cement kiln exhaust. Theory-based models were constructed to estimate both NO{sub x} and SO{sub x} emissions from cement kilns. These models were then applied to estimating the impact of various NO{sub x} control strategies on kiln exhaust emissions. The sulfur model constructed as part of this work was successful at predicting SO{sub 2} emissions and sulfur capture in the Alpena kiln. This model is designed to run as a postprocessing step that uses the output of a NO{sub x} model as input. With an accurate NO{sub x} model, the sulfur model may prove to be a valuable tool in estimating the impact of kiln modifications on sulfur emissions. The NO{sub x} model was also applied to model several operating scenarios on three of Lafarge's kilns: Alpena 20/21, Alpena 22/23, and Ravena 1. The predictions of the flue gas temperature at the kiln feed end, the kiln shell heat loss, the quality of clinker, and the excess O{sub 2} in the flue gas are consistent with the audit data. The developed simulation tool in this project has proven to be an effective way to investigate the NO{sub x} emissions, to optimize kiln performance, and to assess changes in operating condition on kiln performance.
Digital Panel Assembly for Automotive Body-in-White (2002)

This paper presents the methodology of Digital Panel Assembly (DPA), a computer aided approach in automotive body panel assembly. Core to the methodology is special-purpose finite element software, EAVS, that can simulate the panel assembly processes and predict assembly dimensions by taking into considerations of the compliant nature of panels and sub-assemblies. To validate the methodology, a non-contact EOIS optical scanning procedure for panel measurement is established. The validation study shows that the reported methodology can accurately predict the 1st level panel sub-assemblies. Finally, the resource requirements, functional capabilities, and scalability of the digital panel assembly methodology towards a complete Body-in-White implementation are discussed.
Umlagerung des zweifach protonierten [2.2.2]Cryptanden durch Kation‐π‐ und ionische Wechselwirkungen: Synthese und Struktur des [CoCl4]·0.5 C6H5CH3‐Salzes (1996)

Aus einem arenreichen, flüssigen Clathratmedium wurde die Titelverbindung kristallin isoliert. Sie ist das erste Beispiel für eine Verbindung, in der ein Ionophor durch eine NH + 4 ‐π‐Wechselwirkung konformativ stabilisiert wird. Im Kristall liegt ein linearer supramolekularer Komplex aus fünf Komponenten vor (siehe Bild unten), in dem die Cryptatmoleküle entlang ihrer Längsachse gestreckt vorliegen. magnified image
Coated platelets and severe haemophilia A bleeding phenotype: Is there a connection? (2015)

Coated platelet levels were not associated with bleeding phenotype in this study; however, these data may suggest coated platelet levels are lower in haemophilia patients relative to healthy volunteers.
Abietane Diterpenes from Clerodendron cyrtophyllum. (1993)

Tow novel abietane derivatives, cyrtophyllones A (1) and B (2), together with six known compounds, teuvincenone F (3), unicinatone (4), sugiol (5), friedelin (6), clerodolone (7), stigmasta-5, 22, 25-trien-3β-ol (8) and clerosterol (9), were isolated from the stem of Clerodendron cyrtophyllum. One of the abietane diterpenes, cyrtophyllone A, possesses a rearranged-abietane skeleton wich contains a 17(15-16)-abeo-abietane framework. The stereo-structure proposed for 1 was characterized as 16(S)-12, 16-epoxy-11, 14-dihydroxy-6-methoxy-17(15-16)-abeo-abieta-5, 8, 11, 13-tetraen-7-one on the basis of spectral analysis (UV, IR, MS, two dimensional (2D) NMR and CD) and X-ray diffraction. The structure of 2 was also characterized as (+)-11, 12, 16-trihydroxy-abieta-8, 11, 13-trien-7-one by a combination of spectroscopic comparison with sugiol.
Non-Resonant In-Line VIV and Its Implications on Model Tests (2010)

Recently, small-scale experiments were conducted by [1] to study in-line VIV in pipe spans. The experiments were performed with six different pipes of varying stiffness and mass ratio, but with the same length-to-diameter ratio. The response of the pipe with the lowest mass and stiffness, made out of Acrylonitrile Butadiene Styrene (ABS), was surprising. The in-line RMS A/D response of the ABS pipe was larger and over a much wider reduced velocity range than shown in design codes like DnV F105. Since these codes are commonly used to design real pipelines, the authors were interested in understanding these observations. In the past, observations of VIV response over a wide reduced velocity range have been explained using added mass. This paper shows that though added mass could play an important role, observations of the in-line and cross-flow response mode and frequency content suggests that there could be other reasons for the response observed in the experiments. In particular, this paper investigates the observed large response away from the region of resonant VIV and proposes that this non-resonant in-line response could be different from what researchers typically call VIV. The paper also investigates when such a mechanism could contribute to substantial in-line VIV motion. The implications of this work could be significant, not just for pipe-span design but also for scaling pipes for in-line VIV model tests.
Interstitial Cystitis and Bladder Mastocytosis in a Woman with Chronic Urticaria (1997)

A patient with chronic urticaria and angioedema developed endoscopically confirmed interstitial cystitis. Bladder biopsy revealed bladder mastocytosis with > 60 mast cells/mm2 (normal < 10) in the detrusor and submucosa. Most of the mast cells were activated and degranulated. The occurrence of IC in a patient with urticaria and angioedema, diseases both associated with mast cell pathophysiology, supports the role of mast cells in interstitial cystitis.
Reliability Tests for Chip Modules and Smart Cards (2002)

Chapter Nine illustrates how different reliability tests can be executed on the chip module and the final smart card to ensure the functionality of a smart card in daily use. The basics of quality control, AQL and LTPD, are described. Electrical and mechanical tests are described and the usage of acceleration models for the speeding up of reliability tests are explained.
A Productive Programming Environment for Stream Computing (2005)

This paper presents StreamIt and the StreamIt Development Tool. The development tool is an IDE designed to improve the coding, debugging, and visualization of streaming applications by exploiting the ability of the StreamIt language to naturally represent streaming codes as structured, hierarchical graphs. The StreamIt Development Tool aims to emulate the best of traditional debuggers and IDEs while moving toward hierarchical visualization and debugging concepts specialized for streaming applications. As such, it provides utilities for stream graph examination, tracking of data flow between streams, and deterministic execution of parallel streams. These features are in addition to more conventional tools for creating and editing codes, integrated compilers, setting breakpoints, watchpoints, and stepby-step program execution. A user study evaluating StreamIt and the development tool was held at MIT during which participants were given erroneous programs and asked to resolve the programming errors. We compared the productivity of the users when using the StreamIt Development Tool and its graphical features to those who were restricted to lineoriented debugging strategies, and we found that the former produced ten more correct solutions compared to the latter set of users. Furthermore, our data suggests that the graphical tool chain helped to mitigate user frustration and encouraged participants to invest more time tracking and fixing programming errors. 1
Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer (2016)

Tumor-associated macrophages (TAMs) can influence ovarian cancer growth, migration, and metastasis, but the detailed mechanisms underlying ovarian cancer metastasis remain unclear. Here, we have shown a strong correlation between TAM-associated spheroids and the clinical pathology of ovarian cancer. Further, we have determined that TAMs promote spheroid formation and tumor growth at early stages of transcoelomic metastasis in an established mouse model for epithelial ovarian cancer. M2 macrophage-like TAMs were localized in the center of spheroids and secreted EGF, which upregulated αMβ2 integrin on TAMs and ICAM-1 on tumor cells to promote association between tumor cells and TAM. Moreover, EGF secreted by TAMs activated EGFR on tumor cells, which in turn upregulated VEGF/VEGFR signaling in surrounding tumor cells to support tumor cell proliferation and migration. Pharmacological blockade of EGFR or antibody neutralization of ICAM-1 in TAMs blunted spheroid formation and ovarian cancer progression in mouse models. These findings suggest that EGF secreted from TAMs plays a critical role in promoting early transcoelomic metastasis of ovarian cancer. As transcoelomic metastasis is also associated with many other cancers, such as pancreatic and colon cancers, our findings uncover a mechanism for TAM-mediated spheroid formation and provide a potential target for the treatment of ovarian cancer and other transcoelomic metastatic cancers.
Wide Variation in the Multiplicity of HIV-1 Infection among Injection Drug Users (2010)

Recent studies indicate that sexual transmission of human immunodeficiency virus type 1 (HIV-1) generally results from productive infection by only one virus, a finding attributable to the mucosal barrier. Surprisingly, a recent study of injection drug users (IDUs) from St. Petersburg, Russia, also found most subjects to be acutely infected by a single virus. Here, we show by single-genome amplification and sequencing in a different IDU cohort that 60% of IDU subjects were infected by more than one virus, including one subject who was acutely infected by at least 16 viruses. Multivariant transmission was more common in IDUs than in heterosexuals (60% versus 19%; odds ratio, 6.14; 95% confidence interval [CI], 1.37 to 31.27; P = 0.008). These findings highlight the diversity in HIV-1 infection risks among different IDU cohorts and the challenges faced by vaccines in protecting against this mode of infection.
A 40-nm CMOS permittivity sensor for chemical/biological material characterization at RF/microwave frequencies (2016)

This paper presents a complex permittivity sensor, integrated in 40-nm CMOS, for microwave dielectric spectroscopy. It utilizes a single-ended patch as a near-field sensing element, embedded in a double-balanced, fully-differential impedance bridge. A low-IF, multi-harmonic down-conversion scheme is employed to extend the characterization frequency range and increase the measurement speed. The implemented architecture is compact, accurate and fast, thus suitable for the realization of future real-time, microwave-based, 2-D dielectric imagers. Measurements on liquids show an rms error of <1% over a frequency range of 0.1 – 12 GHz.
Direct high frequency measurement method for small diameter coaxial cable (2004)

We are developing a high-quality flexible coaxial cable with a diameter of less than 1 mm. It is difficult to carry out precise measurement using the conventional coaxial connectors that are commercially available. Therefore, we have developed a high frequency measurement method for determining the characteristics of a small-diameter coaxial cable without exclusive connectors. In this method, a time domain reflectometry (TDR) measurement system and a microwave vector network analyzer (VNA) are used with a microwave probe station. The cables are molded using resin and cut vertically with a cutting tool. The surfaces of the cable edges are polished to obtain a good electrical contact. Microwave contact probes (SG or GS type) are used. We have precisely measured the characteristics of 0.8-mm-diameter coaxial cables. The impedance distribution and S parameters were successfully evaluated by TDR and VNA measurement respectively. The impedance distortion at the probe contact was negligible. The effects of the connection performance are discussed in detail.
Quantitative analysis framework for SPECT&#x00B7;CT Tc-99m bone scintigraphy (2011)

Clinical SPECT routine uses tedious manual image evaluation using simplistic region of interest statistical analysis without taking the quantification aspect into account. We introduce a software framework for quantitative analysis of 3D/4D SPECT·CT Tc-99m bone scintigraphy data that incorporates automatic analysis and osseous tissue healthiness classification based on a patient database annotated by an experienced physician. The usage workflow of our framework starts with the input of SPECT and CT data registered on each other. Using CT information we segment osseous tissue also in the co-registered SPECT dataset. Patient weight, injected dose and system calibration factor are read out of the input datasets in order to estimate tracer activity concentration (AC) in kBq/ml and standardized uptake value (SUV). Support vector machine method is used to classify tissue based on the reference patient database that contains quantitative data for normal and abnormal tissue. Evaluation of the framework was done on patient data acquired 3 hours post injection on a SPECT/CT Symbia T6 system using protocol for quantitative estimation of tracer activity. The acquired projection data was reconstructed using Ordered Subset Expectation Maximization with 3D resolution recovery (OSEM-3D) with attenuation and scatter correction. Data analysis showed a significant correlation between AC and bone density measured in Hounsfield Units (HU) for both male and female patients. The proposed methods demonstrate the ability to automatically quantify and distinguish abnormal tissue from healthy one and to increase physicians' diagnostic confidence.
Example of monitoring sound generated from wind turbine (2022)

We developed a monitoring system for sounds generated from wind turbine and measured low-frequency sounds for several weeks. From the results, we introduced a case where a sound including pure tone was observed around 120 Hz when the rotation speed of the wind turbine was high. In addition, an example was shown in which it was determined whether or not wind noise was included in the observation data by using the level difference between the two microphone outputs installed in the large wind screen.
Altering The Composition Of GaInPAs Grown By The Hydride Technique By Introducing HC1 Downstream (1989)

Thermodynamic calculations show that the In and Ga concentrations in GaInPAs change when HC1 is introduced down stream during growth by the hydride method. This results from HC1 reducing the incorporation of In more than it does for Ga. The effect is larger for the initially lattice matched material containing more Ga and therefore emitting light at longer wavelengths. The group V composition also changes with the As mole fraction increasing in intially lattice matched material containing less As and therefore emitting at shorter wavelengths. These results were qualitatively confirmed by experiment. Thus, in principle, lattice matched GaInPAs superlattices can be grown by periodically injecting HC1 downstream and simultaneously adjusting the PH3 and AsH3 flow rates.
Suction catheter for enhanced control and accuracy of transseptal access (2016)

TSAC provides controlled TSA and improves puncture accuracy, while maintaining procedure time and workflow. These findings provide a strong rationale for a first-in-man study to demonstrate the clinical utility of the device.
A complete 4DCT‐ventilation functional avoidance virtual trial: Developing strategies for prospective clinical trials (2017)

Our work demonstrated that 60-70% of stage III patients would be eligible for functional planning and that a typical functional lung mean dose reduction of 2.8 Gy can be expected relative to standard clinical plans. These findings provide salient data for the development of functional clinical trials.
Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology (2014)

Hydrogels and, in particular, supramolecular hydrogels show promising properties for application in regenerative medicine because of their ability to adapt to the natural environment these materials are brought into. However, only few studies focus on the structure-property relationships in supramolecular hydrogels. Here, we study in detail both the structure and the mechanical properties of such a network, composed of poly(ethylene glycol), end-functionalized with ureido-pyrimidinone fourfold hydrogen bonding units. This network is responsive to triggers such as concentration, temperature and pH. To obtain more insight into the sol-gel transition of the system, both rheology and small-angle X-ray scattering (SAXS) are used. We show that the sol-gel transitions based on these three triggers, as measured by rheology, coincide with the appearance of a structural feature in SAXS. We attribute this feature to the presence of hydrophobic domains where cross-links are formed. These results provide more insight into the mechanism of network formation in these materials, which can be exploited for tailoring their behavior for biomedical applications, where one of the triggers discussed might be used.
<title>Control of stress-void formation in aluminum-copper filled vias</title> (1993)

A four layer metal system, designed for high speed bipolar gate arrays, subjected to high temperature aging was found to contain mechanical stress induced voids at the metal to metal interfaces within micron and sub-micron vias. The interconnect metal used in the system, AlCu(1.5%) sputter deposited at high temperatures, literally fills the vias and is quite resistant to stress voiding in the lines. However, thermal aging at 200 degree(s)C with no current flow led to open circuit failures of the 0.8 micron stacked via structures where via two is place directly over via one, and within via one and via two chains as well. The time to failure was studied as a function of temperature, via dimension, and processing changes to both the surrounding dielectric and the metallization. Reliability studies of the original, unmodified via structure, as well as those with process changes as indicated above have identified some of the significant factors affecting stress controlled via reliability.