gebhart/patrepeval huggingface dataset:
Importance of Parallel Vectors and "Hydrophobic Collapse" of the Aligned Aromatic Rings: Discovery of a Potent Substance P Antagonist (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImportance of Parallel Vectors and "Hydrophobic Collapse" of the Aligned Aromatic Rings: Discovery of a Potent Substance P AntagonistManoj C. Desai, Lawrence A. Vincent, and James P. RizziCite this: J. Med. Chem. 1994, 37, 25, 4263–4266Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/jm00051a001https://doi.org/10.1021/jm00051a001research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Damage-free transfer mechanics of 2-dimensional materials: competition between adhesion instability and tensile strain (2021)

Abstract The transfer of two-dimensional (2D) materials is crucial to the realization of 2D material-based devices for practical applications. The thinness of 2D materials renders them prone to mechanical damage during the transfer process and to degradation of their superior electrical and mechanical properties. Herein, the mechanisms involved in the damage of chemical vapor deposition-grown graphene (Gr) and MoS 2 are investigated during a roll-based transfer process. We identify two different damage mechanisms, i.e., instability-induced damage and tensile strain-induced damage. The two mechanisms compete, depending on the thickness of the transfer medium, and induce dissimilar damage. By minimizing these two mechanisms, we realize and demonstrate the damage-free transfer of 2D materials. The sheet resistance and mobility of transferred Gr are 235 ± 29 Ω sq –1 and 2250 cm 2 V –1 s –1 , respectively, with no microscopic cracks or tear-out damage. We observe instability-induced damage to be ubiquitous in monolayer MoS 2 , thin metals, and thin oxide films. By understanding the instability-induced damage mechanism, a broad range of 2D materials and thin films can be transferred without mechanical damage. Damage-free transfer will contribute to the high-yield fabrication of 2D material-based electronic devices.
Data from Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor (2023)

&lt;div&gt;Abstract&lt;p&gt;The Krüppel-like family of transcription factors plays critical roles in human development and is associated with cancer pathogenesis. Krüppel-like factor 5 gene (&lt;i&gt;KLF5&lt;/i&gt;) has been shown to promote cancer cell proliferation and tumorigenesis and to be genomically amplified in cancer cells. We recently reported that the &lt;i&gt;KLF5&lt;/i&gt; gene is also subject to other types of somatic coding and noncoding genomic alterations in diverse cancer types. Here, we show that these alterations activate KLF5 by three distinct mechanisms: (i) Focal amplification of superenhancers activates &lt;i&gt;KLF5&lt;/i&gt; expression in squamous cell carcinomas; (ii) Missense mutations disrupt KLF5–FBXW7 interactions to increase KLF5 protein stability in colorectal cancer; (iii) Cancer type–specific hotspot mutations within a zinc-finger DNA binding domain of KLF5 change its DNA binding specificity and reshape cellular transcription. Utilizing data from CRISPR/Cas9 gene knockout screening, we reveal that cancer cells with &lt;i&gt;KLF5&lt;/i&gt; overexpression are dependent on KLF5 for their proliferation, suggesting KLF5 as a putative therapeutic target.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Significance:&lt;/b&gt; Our observations, together with previous studies that identified oncogenic properties of KLF5, establish the importance of KLF5 activation in human cancers, delineate the varied genomic mechanisms underlying this occurrence, and nominate KLF5 as a putative target for therapeutic intervention in cancer. &lt;i&gt;Cancer Discov; 8(1); 108–25. ©2017 AACR.&lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;i&gt;This article is highlighted in the In This Issue feature, p. 1&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
High-speed, high-reliability GaN power device with integrated gate driver (2018)

An enhancement-mode GaN power switch with monolithically integrated gate driver is demonstrated on a 650-V GaN-on-Si power device platform. The integrated GaN-based gate driver features advanced designs such as bootstrapped gate-charging current source that enables high current driving capability during the entire turn-on process and rail-to-rail output. The GaN power transistor with integrated gate driver was characterized up to 300 V/15 A switching operations using a double pulse tester, and exhibits suppressed gate ringing and fast switching speed. The peak drain voltage slew rate d V/dt is above 125 V/ns during turn-on, and 336 V/ns during turn-off.
ChemInform Abstract: Pinene‐Derived Monodentate Phosphoramidites for Asymmetric Hydrogenation. (2015)

Abstract Newly synthesized phosphoramidite ligands are used in asymmetric catalysis.
Cryptoeconomic Security for Data Availability Committees (2022)

Layer 2 systems have received increasing attention due to their potential to scale the throughput of L1 blockchains. To avoid the cost of putting data on chain, these systems increasingly turn to off-chain data availability solutions such as data availability committees (DACs). However, placing trust on DACs conflicts with the goal of obtaining an L2 architecture whose security relies solely on the L1 chain. To eliminate such trust assumptions, we propose a DAC protocol that provides financial incentives to deter the DAC nodes from adversarial behavior such as withholding data upon request. We then analyze the interaction of rational DAC nodes and clients as a dynamic game, with a Byzantine adversary that can corrupt and bribe the participants. We also define a notion of optimality for the DAC protocols, inspired by fairness and economic feasibility. Our main result shows that our protocol is optimal and guarantees security with the highest possible probability under reasonable assumptions on the adversary.
Induction of regulatory T cell–resistant helper CD4+ T cells by bacterial vector (2007)

Salmonella typhimurium engineered to deliver cancer/testis antigen NY-ESO-1 through type III secretion (S typhimurium-NY-ESO-1) was shown to be an efficient cancer vaccine construct in mice and to stimulate NY-ESO-1-specific CD8(+)/CD4(+) T cells in vitro in patients with cancer with NY-ESO-1 spontaneous immunity. We also showed that individuals without spontaneous immunity to NY-ESO-1 had specific CD4(+) T-cell precursors with high avidity to NY-ESO-1 under tight control by CD4(+)CD25(+) regulatory T (Treg) cells. We now found that in healthy donors and patients with melanoma without NY-ESO-1 spontaneous immunity, S typhimurium-NY-ESO-1 elicits CD4(+) T helper 1 (Th1) cells in vitro recognizing naturally processed antigen from these high-avidity NY-ESO-1-specific naive precursors. In contrast to peptide stimulation, induction of specific Th1 cells with S typhimurium-NY-ESO-1 did not require in vitro depletion of CD4(+)CD25(+) Treg cells, and this prevailing effect was partially blocked by disruption of interleukin-6 or glucocorticoid-induced TNF receptor (GITR) signals. Furthermore, S typhimurium-induced Th1 cells had higher GITR expression than peptide-induced Th1 cells and were resistant to suppression by CD4(+)CD25(+) Treg cells in a GITR-dependent fashion. We propose that S typhimurium-NY-ESO-1 induces antigen-specific T-cell responses that are resistant to suppression by CD4(+)CD25(+) Treg cells.
High resolution prism based SPR imaging for the study and early detection of bacteria (2019)

International audience
Simple two-step synthesis of 2,4-disubstituted pyrroles and 3,5-disubstituted pyrrole-2-carbonitriles from enones (2014)

The cyclocondensation of enones with aminoacetonitrile furnishes 3,4-dihydro-2H-pyrrole-2-carbonitriles which can be readily converted to 2,4-disubstituted pyrroles by microwave-induced dehydrocyanation. Alternatively, oxidation of the intermediates produces 3,5-disubstituted pyrrole-2-carbonitriles.
Exponentially more precise quantum simulation of fermions in second quantization (2016)

We introduce novel algorithms for the quantum simulation of fermionic systems which are dramatically more efficient than those based on the Lie–Trotter–Suzuki decomposition. We present the first application of a general technique for simulating Hamiltonian evolution using a truncated Taylor series to obtain logarithmic scaling with the inverse of the desired precision. The key difficulty in applying algorithms for general sparse Hamiltonian simulation to fermionic simulation is that a query, corresponding to computation of an entry of the Hamiltonian, is costly to compute. This means that the gate complexity would be much higher than quantified by the query complexity. We solve this problem with a novel quantum algorithm for on-the-fly computation of integrals that is exponentially faster than classical sampling. While the approaches presented here are readily applicable to a wide class of fermionic models, we focus on quantum chemistry simulation in second quantization, perhaps the most studied application of Hamiltonian simulation. Our central result is an algorithm for simulating an N spin–orbital system that requires N t5 ( ) ~ gates. This approach is exponentially faster in the inverse precision and at least cubically faster in N than all previous approaches to chemistry simulation in the literature.
Electrical Properties of SIC-ALN Composites (2008)

Aluminum nitride and silicon carbide are two materials with drastically different electrical properties. Silicon carbide is a semiconductor and aluminum nitride is an insulator. In this study, the electrical properties of ceramic compacts containing various ratios of SiC and AIN were studied. The combined use of three different impedance analyzers allows the frequency response to be measured from 10−5 Hz up to 109 Hz. It was found that both SiC and AIN pure samples show an interfacial relaxation. Addition of SiC to AIN results in an extended solid solution which shows an increasing dielectric constant. Addition of AIN to SiC results in a diminishing interfacial polarization, which enhances the low frequency conductivity.
Two-phase study of hepatic artery vascular occlusion with microencapsulated cisplatin in patients with liver metastases from neuroendocrine tumors. (1998)

Hepatic artery vascular occlusion therapy using encapsulated cisplatin is feasible, can palliate symptoms, and can produce biochemical and objective responses in liver metastases from neuroendocrine tumors. The maximum tolerated dose appears to be 100 mg/m2 of body surface area per treatment. Polylactic acid capsules have potential because they can incorporate multiple agents. With surface coating, such capsules can also be used to target specific receptors.
Gadonanostructures as Magnetic Resonance Imaging Contrast Agents (2010)

This chapter contains sections titled: Magnetic Resonance Imaging (MRI) and the Role of Contrast Agents (CAs) The Advantages of Gadonanostructures as MRI Contrast Agent Synthons Gadofullerenes as MRI Contrast Agents Understanding the Relaxation Mechanism of Gadofullerenes Gadonanotubes as MRI Contrast Agents Acknowledgement References
Synthesis and single-crystal x-ray structural investigation of 1,1-bis(pentacarbonylmanganio)-3,4-dimethylgermacyclopent-3-ene and bis[1-(tetracarbonylferrio)-3,4-dimethylgermacyclopent-3-ene]: the first evidence for a puckered ground-state conformation in germacyclopent-3-enes (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and single-crystal x-ray structural investigation of 1,1-bis(pentacarbonylmanganio)-3,4-dimethylgermacyclopent-3-ene and bis[1-(tetracarbonylferrio)-3,4-dimethylgermacyclopent-3-ene]: the first evidence for a puckered ground-state conformation in germacyclopent-3-enesDeqing Lei, Mark J. Hampden-Smith, Eileen N. Duesler, and John C. HuffmanCite this: Inorg. Chem. 1990, 29, 4, 795–798Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://doi.org/10.1021/ic00329a044RIGHTS & PERMISSIONSArticle Views65Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (529 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Unraveling the Structural Puzzle of the Giant Glutenin Polymer—An Interplay between Protein Polymerization, Nanomorphology, and Functional Properties in Bioplastic Films (2018)

A combination of genotype, cultivation environment, and protein separation procedure was used to modify the nanoscale morphology, polymerization, and chemical structure of glutenin proteins from wheat. A low-polymerized glutenin starting material was the key to protein-protein interactions mainly via SS cross-links during film formation, resulting in extended β-sheet structures and propensity toward the formation of nanoscale morphologies at molecular level. The properties of glutenin bioplastic films were enhanced by the selection of a genotype with a high number of cysteine residues in its chemical structure and cultivation environment with a short grain maturation period, both contributing positively to gluten strength. Thus, a combination of factors affected the structure of glutenins in bioplastic films by forming crystalline β-sheets and propensity toward the ordered nanostructures, thereby resulting in functional properties with high strength, stiffness, and extensibility.
Optimized Smart Grid Energy Procurement for LTE Networks Using Evolutionary Algorithms (2014)

Energy efficiency aspects in cellular networks can contribute significantly to reducing worldwide greenhouse gas emissions. The base station (BS) sleeping strategy has become a well-known technique to achieve energy savings by switching off redundant BSs mainly for lightly loaded networks. Moreover, introducing renewable energy as an alternative power source has become a real challenge among network operators. In this paper, we formulate an optimization problem that aims to maximize the profit of Long-Term Evolution (LTE) cellular operators and to simultaneously minimize the CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> emissions in green wireless cellular networks without affecting the desired quality of service (QoS). The BS sleeping strategy lends itself to an interesting implementation using several heuristic approaches, such as the genetic (GA) and particle swarm optimization (PSO) algorithms. In this paper, we propose GA-based and PSO-based methods that reduce the energy consumption of BSs by not only shutting down underutilized BSs but by optimizing the amounts of energy procured from different retailers (renewable energy and electricity retailers), as well. A comparison with another previously proposed algorithm is also carried out to evaluate the performance and the computational complexity of the employed methods.
Benchmarking EUV mask inspection beyond 0.25 NA (2008)

The SEMATECH Berkeley Actinic Inspection Tool (AIT) is an EUV zoneplate microscope dedicated to photomask research. Recent upgrades have given the AIT imaging system selectable numerical aperture values of 0.25, 0.30, and 0.35 (4 equivalent). The highest of which provides resolution beyond the current generation of EUV lithography research tools, giving above 75% contrast for dense-line features with 100-nm half-pitch on the mask, and above 70% for 88-nm half-pitch. To improve the imaging system alignment, we used through-focus images of small contacts to extract aberration magnitudes and compare with modeling. The astigmatism magnitude reached a low value of 0.08 waves RMS. We present the results of performance benchmarking and repeatability tests including contrast, and line width measurements.
Implementation of Real-Time Channel Module for Applying Wireless Communication Environments (2016)

본 논문은 소프트웨어 라디오 범용 하드웨어 USRP(Universal Software Radio Peripheral) 보드와 데이터 수집 및 분석을 위한 프로그램 LabVIEW(Laboratory Virtual Instrument Engineering Workbench)를 이용하여 실시간으로 무선 통신 환경을 적용할 수 있는 채널 모듈을 구현하였다. 제안된 모듈은 기존에 하드웨어로 구현된 인지 무선, 주파수 간섭 분석 등의 시뮬레이터와 함께 쓰여 해당 테스트베드의 전파 환경에 대한 신뢰도를 높일 수 있다. 게다가, 통신 가능한 데이터 전송속도가 한정적이라는 기존 하드웨어 시뮬레이터의 한계를 모듈내의 설계를 통해 극복하였다. 이와 더불어 원하는 통신 시스템의 동작주파수, 안테나 출력, 송수신기 간의 거리 등의 채널 파라미터를 입력하여 보다 쉽게 통신 성능을 예측할 수 있고, 추후 새로운 시나리오 및 통신 채널을 구현할 시에 유연하게 적용할 수 있다는 장점을 가지고 있다. 본 논문에서 모듈을 이용해 시나리오에 따른 통신 성능을 성상도 및 BER을 통해 예측하였고, 이 결과를 통해 제안된 모듈을 이용한 통신 성능 예측이 가능함을 확인하였다. In this paper, A real-time channel module which can apply the wireless propagation channel was developed using USRP and Lab-VIEW. When the proposed channel module is used in conjunction with the implemented HW(hardware) simulators for cognitive radio and frequency interference analysis and so on, it can increase the reliability about wireless propagation environments. In addition, the proposed module overcomes the limit of existing HW simulator that data transfer rate is limitative in communication system through the design of the inner parts. Along with this, it is possible to apply channel parameters necessary to estimate the easier communication performance. Also, this has the advantage that it can be flexibly applied in implementing the communication channel with the upcoming new scenarios. The proposed module can estimate the communication performance via constellation and BER using the implemented module.
Robotic Revelation (2003)

Perer, Elise MD*; Lee, David I MD*; Ahlering, Thomas MD, FACS*, **; Clayman, Ralph V MD, FACS* Author Information
Light-harvesting pigment distribution in algae and cyanobacteria determined by hyperspectral confocal fluorescence microscopy. (2011)

Abstract not provided.
Telmisartan ameliorates carbon tetrachloride‐induced acute hepatotoxicity in rats (2016)

This study assessed the potential hepatoprotective effect of telmisartan (TLM), a selective angiotensin II type 1 (AT<sub>1</sub> ) receptor blocker, on carbon tetrachloride (CCl<sub>4</sub> )-induced acute hepatotoxity in rats. Intraperitoneal injection of male Wistar rats with CCl<sub>4</sub> 1 mL kg<sup>-1</sup> , 1:1 mixture with corn oil for 3 days increased serum alanine transaminase, aspartate transaminase, and alkaline phosphatase activities as well as total bilirubin, triglycerides and total cholesterol levels. This is in addition to the disrupted histological architecture in the CCl<sub>4</sub> group. Rats receiving CCl<sub>4</sub> and co-treated with TLM (3 and 10 mg kg<sup>-1</sup> , orally) showed ameliorated serum biochemical and histological changes almost to the control level. Nevertheless, rats treated with TLM (1 mg kg<sup>-1</sup> ) didn't show any significant changes compared to CCl<sub>4</sub> intoxicated group. In addition, TLM rectified oxidative status disrupted by CCl<sub>4</sub> intoxication. Interestingly, TLM protected against CCl<sub>4</sub> -induced expressions of nuclear factor-κB, inducible nitric oxide synthase and cyclooxygenase-II, in a dose related manner. Moreover, TLM (3 and 10 mg kg<sup>-1</sup> ) significantly modified CCl<sub>4</sub> -induced elevation in tumor necrosis factor-α and nitric oxide levels. Furthermore, TLM showed a marked decline in CD68+ cells stained areas and reduced activity of myeloperoxidase enzyme compared to CCl<sub>4</sub> -intoxicated group. In conclusion, both doses of TLM (3 and 10 mg kg<sup>-1</sup> ) showed significant hepato-protective effects. However, TLM at a dose of 10 mg kg<sup>-1</sup> didn't show significant efficacy above 3 mg kg<sup>-1</sup> which is nearly equivalent to the human anti-hypertensive dose of 40 mg. Thus, may be effective in guarding against several hepatic complications due to its antioxidant and anti-inflammatory activities. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 359-370, 2017.
Visualisation of Multiple Tight Junctional Complexes in Human Airway Epithelial Cells (2018)

The present study demonstrates the importance of a personalised approach to optimise staining for the visualisation of different tight junction proteins. Of significance, the workflow, once optimised, can readily be translated into primary airway epithelial cell air-liquid interface cultures where it can be used to assess barrier integrity in chronic lung diseases.
Neuroendocrine tumor of the nasal cavity (esthesioneuroblastome) : about one case with paraneoplastic Cushing's syndrome. (1989)

peer reviewed
The CARD plays a critical role in ASC foci formation and inflammasome signalling (2012)

The ASC (apoptosis speck-like protein) is a key component of multimeric protein complexes that mediate inflammation and host defence. Comprising a PYD (Pyrin) domain and a CARD (caspase activation and recruitment domain), ASC functions downstream of NLRs (nucleotide-binding domain, leucine-rich repeat-containing receptors) and AIM2 (absent in melanoma 2) through the formation of supramolecular structures termed inflammasomes. However, the mechanism underlying ASC signalling and its dependency on oligomeric arrangements in inflammasome formation remain poorly understood. When expressed in cells, ASC forms discrete foci (called 'specks') typically with one speck per cell. We employed a BiFC (bimolecular fluorescence complementation) system to investigate and visualize ASC foci formation in living cells. We demonstrated that the CARD of ASC plays a central role in ASC inflammasome assembly, representing the minimal unit capable of forming foci in conjunction with the caspase 1 CARD. Mutational studies point to multiple surfaces on the ASC CARD and two predominant areas on the caspase 1 CARD mediating the formation of ASC/caspase 1 foci. The lack of foci formation for ASC CARD mutants correlates with a loss of IL-1β (interleukin 1β) processing in response to NLRP (NLR family, PYD domain-containing) 3 or AIM2 agonists in RAW264.7 cell reconstitution assays. Analogously, we show that productive formation of the Salmonella typhimurium-induced NLRC4 (NLR family CARD domain-containing protein 4) inflammasome is dependent on ASC-CARD-mediated platform formation. Thus the results of the present study depict a central role of CARDs in the formation of ASC signalling platforms and provide an important tool for investigation of CARD-dependent networks.