gebhart/patrepeval huggingface dataset:
An Adaptive Analog Front End for a Flexible PPG Sensor Patch with Self-Determined Motion Related DC Drift Removal (2021)

This paper presents, a DC drift compensated (due to motion <; 1Hz), high sensing precision and wide dynamic range analog front end (AFE) for the organic type PPG sensor. The proposed AFE utilizes an auto-programmable trans-impedance amplifier (TIA) with the DC-current cancellation loop and a band pass filter to compensate the DC drift either due to motion or ambient light change. The prototype of the readout circuit is implemented in an integrated chip with an area of 3mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> via the TSMC 180nm process. The experiment result shows that the designed readout can sense linearly from 1nA to maximum 40μ current, with a resultant dynamic range of 90dB and the measured input-referred noise is 0.256 nA/ V Hz. The total measured power consumption of the readout circuit is 460μW, while the power consumption of the on-chip OLED driver is 1.8 mW. The obtained PPG signals from the wrist are subsequently processed with quality checking, and feature extraction. The measured accuracy and standard error for the heart rate estimation are 96%, and -0.12±5 beats/minute, respectively.
Characteristic Mode Analysis of U-Shaped Folded Dipole Antenna for WiMAX (2019)

U-Shaped Folded Dipole Antenna (UFDA) have been proposed for WiMAX. UFDA element is placed on the ground plane so that the occupied volume of the UFDA element is reduced as much as possible. In this paper, Characteristic Mode Analysis (CMA) is used for the analysis of UFDA, which is composed of UFDA element and the ground plane. As a result, it is found that two types of modes in the resonance of UFDA occur. The one is the mode of UFDA element and the other is the mode of the ground plane. Two frequency bands of WiMAX can be covered, when the shape of UFDA is adjusted by using the result of CMA.
NISP: Pruning Networks Using Neuron Importance Score Propagation (2018)

To reduce the significant redundancy in deep Convolutional Neural Networks (CNNs), most existing methods prune neurons by only considering the statistics of an individual layer or two consecutive layers (e.g., prune one layer to minimize the reconstruction error of the next layer), ignoring the effect of error propagation in deep networks. In contrast, we argue that for a pruned network to retain its predictive power, it is essential to prune neurons in the entire neuron network jointly based on a unified goal: minimizing the reconstruction error of important responses in the "final response layer" (FRL), which is the second-to-last layer before classification. Specifically, we apply feature ranking techniques to measure the importance of each neuron in the FRL, formulate network pruning as a binary integer optimization problem, and derive a closed-form solution to it for pruning neurons in earlier layers. Based on our theoretical analysis, we propose the Neuron Importance Score Propagation (NISP) algorithm to propagate the importance scores of final responses to every neuron in the network. The CNN is pruned by removing neurons with least importance, and it is then fine-tuned to recover its predictive power. NISP is evaluated on several datasets with multiple CNN models and demonstrated to achieve significant acceleration and compression with negligible accuracy loss.
ANTIFIBROTIC AND ANTIOXIDANT THERAPIES PREVENT THE DEVELOPMENT OF FIBROSIS ASSOCIATED WITH TYPE 1 DIABETES IN THE PENILE CORPORA CAVERNOSA OF THE INOS KNOCK OUT MOUSE (2009)

You have accessJournal of Urology1 Apr 2009ANTIFIBROTIC AND ANTIOXIDANT THERAPIES PREVENT THE DEVELOPMENT OF FIBROSIS ASSOCIATED WITH TYPE 1 DIABETES IN THE PENILE CORPORA CAVERNOSA OF THE INOS KNOCK OUT MOUSE Monica G Ferrini, Joanne Moon, Steve Rivera, Jacob Rajfer, and Nestor F. Gonzalez-Cadavid Monica G FerriniMonica G Ferrini More articles by this author , Joanne MoonJoanne Moon More articles by this author , Steve RiveraSteve Rivera More articles by this author , Jacob RajferJacob Rajfer More articles by this author , and Nestor F. Gonzalez-CadavidNestor F. Gonzalez-Cadavid More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60850-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "ANTIFIBROTIC AND ANTIOXIDANT THERAPIES PREVENT THE DEVELOPMENT OF FIBROSIS ASSOCIATED WITH TYPE 1 DIABETES IN THE PENILE CORPORA CAVERNOSA OF THE INOS KNOCK OUT MOUSE." The Journal of Urology, 181(4S), pp. 298–299 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 298-299 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Monica G Ferrini More articles by this author Joanne Moon More articles by this author Steve Rivera More articles by this author Jacob Rajfer More articles by this author Nestor F. Gonzalez-Cadavid More articles by this author Expand All Advertisement PDF downloadLoading ...
ChemInform Abstract: TRIBOLUMINESCENCE, PHOTOLUMINESCENCE, AND HIGH‐PRESSURE SPECTROSCOPY OF TETRACYANOPLATINATE SALTS. DETERMINATION OF THE PRESSURE AT TRIBOLUMINESCENT SITES (1985)

Abstract Die Tetracyanoplatinate(II) M"[Pt(CN)4]‐ nH 2 O mit Mx: KLi, KNa, 1/2 (CszCa) und Csz zeigen unter hydrostatischen Hochdruckbedingungen starke, druckabhängige Verschiebungen der Lumineszenzmaxima (bis zu 320 cm ‐1 Vkbar).
ChemInform Abstract: Cation Radicals with 2‐Pyridylhydrazones in Nitrile Solvents. s‐Triazolo[4,3‐a]pyridines by Thianthrene Cation Radical Perchlorate and 1‐(2‐Pyridyl)‐1,2,4‐triazoles by Tris(2,4‐dibromophenyl)aminium Hexachloroantimonate. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Electrically Pumped Supermode Si/InGaAsP Hybrid Lasers (2010)

Supermode Si/InGaAsP hybrid lasers with a varying-width Si waveguide have been fabricated and shown to be superior to those lasers with a uniform-width Si waveguide. Edge emission images demonstrate mode evolution.
Hot Chips 30 (2019)

The articles in this special section reports on the 2018 Hot Chips conference which covers technical details about these chips, including technology, fundamental algorithms, packaging techniques, architecture, and circuit details. The emphasis is on real chips and applications which are part of actual products; although we do have our share of research talks, we explicitly avoid theoretical talks and marketing hype.
Algorithm-Architecture Co-Optimization of Area-Efficient SDR Baseband for Highly Diversified Digital TV Standards (2012)

The rapidly evolving and diversifying wireless landscape demands highly flexible wireless chipsets. Due to the ultimate programmability, SDR solutions are becoming more and more attractive. However, the programmability overhead is still a concern for the silicon area cost of SDR solutions. In this work, we prove that, with algorithm and architecture co- design, SDR solutions can be very competitive even when compared to highly optimized ASICs. Specifically, we show a baseband processor design that can support ISDB-T, DVB-T and ATSC, but the area cost is still comparable to the combination of ASICs which handle the three terrestrial digital TV standards respectively.
<title>Improved image segmentation techniques for hybrid waveform/object-oriented coding</title> (1994)

A current topic in image coding is to investigate how the efficiency of conventional waveform coding can be improved by utilizing methods from image analysis, image segmentation, image understanding and computer vision. A very promising approach to this problem is object- oriented analysis-synthesis coding and its combination with conventional waveform codecs (hybrid waveform/object-oriented coding). One of the most important key components needed for such a hybrid system is a reliable and generic image segmentation. In this context the underlying contribution presents an algorithm for segmenting objects in front of moving backgrounds. This algorithm is based on four subsequent processing steps which are explained in detail: pre-segmentation by using a Hough transform of conventionally estimated vector fields, global parameter mapping within the pre-segmented background area, compensation of the global background motion, thresholding and post-processing of the remaining DFD signal.
Expression of T cell differentiation antigens and Ia on rat cytotoxic T lymphocytes. (1982)

Study of lymphocyte subsets has been facilitated by the detection of various surface markers that are related to distinct functions. We have explored the use of affinity methods for separation of large quantities (10(8)) of rat cells and used this technique to identify surface markers of cytotoxic T lymphocytes. Splenocytes from animals bearing skin allografts for 7 days were depleted of B cells and were separated into T cell subsets by using W3/25 and OX8 monoclonal antibodies, which mark two nonoverlapping populations of peripheral T cells. Our results demonstrate that the cytotoxic T cells are W3/25- and OX8+. They also bear minimal or no Ag-F alloantigen, a peripheral T cell marker, and they express Ia-like products analogous to those of the mouse I-A subregion but not of the I-E/C subregion.
A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties (2015)

Neurotensin receptors have been studied as molecular targets for the treatment of pain, schizophrenia, addiction, or cancer. Neurotensin (NT) and Contulakin-G, a glycopeptide isolated from a predatory cone snail Conus geographus, share a sequence similarity at the C-terminus, which is critical for activation of neurotensin receptors. Both peptides are potent analgesics, although affinity and agonist potency of Contulakin-G toward neurotensin receptors are significantly lower, as compared to those for NT. In this work, we show that the weaker agonist properties of Contulakin-G result in inducing significantly less desensitization of neurotensin receptors and preserving their cell-surface density. Structure-activity relationship (SAR) studies suggested that both glycosylation and charged amino acid residues in Contulakin-G or NT played important roles in desensitizing neurotensin receptors. Computational modeling studies of human neurotensin receptor NTS1 and Contulakin-G confirmed the role of glycosylation in weakening interactions with the receptors. Based on available SAR data, we designed, synthesized, and characterized an analog of Contulakin-G in which the glycosylated amino acid residue, Gal-GalNAc-Thr10, was replaced by memantine-Glu10 residue. This analog exhibited comparable agonist potency and weaker desensitization properties as compared to that of Contulakin-G, while producing analgesia in the animal model of acute pain following systemic administration. We discuss our study in the context of feasibility and safety of developing NT therapeutic agents with improved penetration across the blood-brain barrier. Our work supports engineering peptide-based agonists with diverse abilities to desensitize G-protein coupled receptors and further emphasizes opportunities for conotoxins as novel pharmacological tools and drug candidates.
Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies (2011)

Single nucleotide polymorphism arrays (SNP-As) have emerged as an important tool in the identification of chromosomal defects undetected by metaphase cytogenetics (MC) in hematologic cancers, offering superior resolution of unbalanced chromosomal defects and acquired copy-neutral loss of heterozygosity. Myelodysplastic syndromes (MDSs) and related cancers share recurrent chromosomal defects and molecular lesions that predict outcomes. We hypothesized that combining SNP-A and MC could improve diagnosis/prognosis and further the molecular characterization of myeloid malignancies. We analyzed MC/SNP-A results from 430 patients (MDS = 250, MDS/myeloproliferative overlap neoplasm = 95, acute myeloid leukemia from MDS = 85). The frequency and clinical significance of genomic aberrations was compared between MC and MC plus SNP-A. Combined MC/SNP-A karyotyping lead to higher diagnostic yield of chromosomal defects (74% vs 44%, P < .0001), compared with MC alone, often through detection of novel lesions in patients with normal/noninformative (54%) and abnormal (62%) MC results. Newly detected SNP-A defects contributed to poorer prognosis for patients stratified by current morphologic and clinical risk schemes. The presence and number of new SNP-A detected lesions are independent predictors of overall and event-free survival. The significant diagnostic and prognostic contributions of SNP-A-detected defects in MDS and related diseases underscore the utility of SNP-A when combined with MC in hematologic malignancies.
Targeted knockout of a chemokine-like gene increases anxiety and fear responses (2018)

Emotional responses, such as fear and anxiety, are fundamentally important behavioral phenomena with strong fitness components in most animal species. Anxiety-related disorders continue to represent a major unmet medical need in our society, mostly because we still do not fully understand the mechanisms of these diseases. Animal models may speed up discovery of these mechanisms. The zebrafish is a highly promising model organism in this field. Here, we report the identification of a chemokine-like gene family, <i>samdori</i> (<i>sam</i>), and present functional characterization of one of its members, <i>sam2</i> We show exclusive mRNA expression of s<i>am2</i> in the CNS, predominantly in the dorsal habenula, telencephalon, and hypothalamus. We found knockout (KO) zebrafish to exhibit altered anxiety-related responses in the tank, scototaxis and shoaling assays, and increased <i>crh</i> mRNA expression in their hypothalamus compared with wild-type fish. To investigate generalizability of our findings to mammals, we developed a <i>Sam2</i> KO mouse and compared it to wild-type littermates. Consistent with zebrafish findings, homozygous KO mice exhibited signs of elevated anxiety. We also found bath application of purified SAM2 protein to increase inhibitory postsynaptic transmission onto CRH neurons of the paraventricular nucleus. Finally, we identified a human homolog of <i>SAM2</i>, and were able to refine a candidate gene region encompassing <i>SAM2</i>, among 21 annotated genes, which is associated with intellectual disability and autism spectrum disorder in the 12q14.1 deletion syndrome. Taken together, these results suggest a crucial and evolutionarily conserved role of <i>sam2</i> in regulating mechanisms associated with anxiety.
Inhibition by rat diazepam-binding inhibitor/acyl-CoA-binding protein of glucose-induced insulin secretion in the rat (1994)

Diazepam-binding inhibitor (DBI) has been localized immunohistochemically in many organs. In porcine and rat pancreas, DBI is present in non-B-cells of the pancreatic islets. Porcine peptide also has been shown to suppress insulin secretion from rat pancreas in vitro. Recently, acyl-CoA-binding protein (ACBP) was isolated from rat liver and shown to be identical structurally to DBI isolated from rat brain. Using this rat DBI/ACBP, we have studied its effects on glucose-stimulated insulin secretion in the rat, both in vivo and in isolated pancreatic islets. Infusion iv of rDBI/ACBP (25 pmol/min) during glucose stimulation induced a moderate and transient reduction of plasma insulin levels. Moreover, rDBI/ACBP suppressed insulin release from batch-incubated isolated islets, stimulated by 16.7 mmol/l glucose, by 24% at 10 nmol/l (p < 0.05) and by 40% at 100 nmol/l (p < 0.01). The peptide (100 nmol/l) also inhibited the insulin response to glucose (16.7 mmol/l) from perifused rat islets by 31% (p < 0.05), mainly by affecting the acute-phase response. Finally, incubation of isolated islets in the presence of rDBI/ACBP antiserum (diluted 1:100 and 1:300) augmented the insulin response to 16.7 mmol/l glucose (p < 0.05 or even less). We conclude that rDBI/ACBP, administered iv or added to the incubation media, suppresses insulin secretion in the rat but that the effect is moderate despite the high concentration used. It is therefore unlikely that the peptide modulates islet hormone release, acting as a classical hormone via the circulation. However, the occurrence of DBI/ACBP in the islets and the enhancing effect by the rDBI/ACBP antibodies on glucose-stimulated insulin release suggest that the peptide is a local modulator of insulin secretion.
Intracellular chloride activities in canine tracheal epithelium. Direct evidence for sodium-coupled intracellular chloride accumulation in a chloride-secreting epithelium. (1983)

Canine tracheal epithelium secretes Cl via an electrogenic transport process that appears to apply to a wide variety of secretory epithelia. To examine the mechanisms involved, intracellular chloride activity, acCl, was measured with Cl-selective intracellular microelectrodes. The results indicate that when the rate of secretion was minimal acCl was 37 mM; with stimulation of secretion the intracellular voltage depolarized, but acCl was not significantly altered, at 39 mM. These findings indicate that: (a) Cl is accumulated across the basolateral membrane under nonsecreting and secreting conditions at an activity 3.8 and 2.4 times, respectively, that predicted for an equilibrium distribution; (b) Cl exit across the apical membrane may be passive with an electrochemical driving force of 22 mV; and (c) stimulation of secretion enhanced the rate of Cl entry across the basolateral membrane, since Cl transport increased without a change in acCl. In the absence of Na in the extracellular fluid, acCl approached the value expected for an equilibrium distribution. This finding suggests that "uphill" entry of Cl into the cell against its electrochemical gradient is dependent upon, and energized by, the entry of Na down its gradient. Submucosal bumetanide, a loop diuretic, also decreased the rate of Cl secretion and decreased acCl, indicating an inhibition of Cl entry. These findings indicate that Cl entry into the cell is directed against its electrochemical gradient and is mediated by a Na-coupled, bumetanide-inhibitable, transport process at the basolateral membrane and that Cl may exit passively down a favorable electrochemical gradient across the apical membrane.
Regulation of calcium channels by RGK proteins (2010)

The RGK family of proteins, small GTPases of the Ras superfamily, are known to regulate calcium currents. It is commonly thought that this is due to an interaction with the Cavβ subunit, however, the mechanism of this inhibition is unclear. There have been conflicting reports of whether RGK proteins can affect channel trafficking or whether they reduce calcium currents by interacting with channels at the membrane. In the last year, several studies have emerged which explore the intricacies of RGK protein interaction with the channel itself and the importance of the Cavβ subunit for this interaction, in addition to providing some tantalizing suggestions for the mechanism by which RGK proteins reduce or eliminate calcium currents. In this review, we present an overview of these recent advances and suggest a model that may synthesize these latest works.
IκBα and IκBβ possess injury context-specific functions that uniquely influence hepatic NF-κB induction and inflammation (2004)

IkappaB proteins play an important role in regulating NF-kappaB induction following a diverse range of environmental injuries. Studies evaluating IkappaBbeta knock-in mice (AKBI), in which the IkappaBalpha gene is replaced by the IkappaBbeta cDNA, have uncovered divergent properties of IkappaBalpha and IkappaBbeta that influence their ability to activate hepatic NF-kappaB and subsequent downstream proinflammatory processes in a stimulus-specific manner. While AKBI mice demonstrated identical levels of hepatic NF-kappaB activation in response to endotoxin, a significantly reduced level of hepatic NF-kappaB activation was observed in AKBI mice after liver ischemia/reperfusion (I/R) injury. This reduced level of NF-kappaB activation in AKBI mice after liver I/R also correlated with decreased induction of serum TNF-alpha, reduced hepatic inflammation, and increased survival. In contrast, no differences in any of these indicators were observed between AKBI mice and WT littermates after a lethal injection of LPS. Molecular studies suggest that the specificity of IkappaBalpha, but not IkappaBbeta, to properly regulate NF-kappaB induction during the acute phase of I/R injury is due to injury context-specific activation of c-Src and subsequent tyrosine phosphorylation of IkappaBalpha on Tyr42. These results demonstrate that IkappaBalpha and IkappaBbeta play unique injury context-specific roles in activating NF-kappaB-mediated proinflammatory responses and suggest that strategies aimed at inhibiting IkappaBalpha gene expression may be of potential therapeutic benefit in hepatic I/R injury.
[Interaction of 3'-fluoro-3'-deoxyanalogs of a trimer of (2'-5')oligoadenylic acid with (2'-5')A3-antibodies: stereochemical aspect]. (1999)

Mouse antibodies to (2'-5')oligoadenylates were obtained by the immunization of animals with the (2'-5')oligoadenylic acid trimer conjugated with bovine serum albumin through a 2',3'-levulinic acid residue. Using radioimmunoassay, the reactivity of mouse polyclonal antibodies to the (2'-5')oligoadenylic acid trimer was studied for the trimer analogues containing 9-(3-deoxy-3-fluro-beta-D- xylofuranosyl)adenine and 3'-deoxy-3'-fluoro-adenosine in various positions of the chain. It was found that (a) the three-dimensional structure of short oligonucleotides is an important factor in the antibody recognition; (b) antibodies are more sensitive to modifications of the 5'-terminal and central ribose fragments of the (2'-5')oligoadenylic acid trimer; (c) the 3'-hydroxyl group plays a secondary role in the formation of the antigen determinant.
Thinfilm Deposition and Characteristics of Calcium-Silicates Bioglass (2007)

Various composition of calcium-silicate thinfilms were deposited to the thickness of 1μm by electron-beam deposition. The composition was varied by changing the composition of source. The Si concentration of thinfilm was ranged from 25 at% to 85 at%, evaluated by EDS. The specimens were immersed into PBS solution at 37 °C. Changes of the morphology and calcium phosphate formation on the specimens were examined by SEM. If the concentration of calcium is high, the calcium phosphate was quickly formed on the specimen. However, the calcium phosphate formed on the high calcium oxide concentration exhibited very poor adhesion onto the substrate. There is a range of appropriate calcium oxide concentration to use as a surface modification method for dental or orthopedic implants.
Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness (2021)

Critical illness is associated with rapid, specific and coordinated alterations in the cellular respiratory machinery, intermediary metabolism and redox response, with different trajectories in survivors and non-survivors. Unravelling the cellular and molecular foundation of human resilience may enable the development of more effective life-support strategies.