gebhart/patrepeval huggingface dataset:
Pump-phase-noise-free optical wavelength data exchange between QAM signals with 50-GHz channel-spacing using coherent DFB pump (2016)

An important challenge for implementing optical signal processing functions such as wavelength conversion or wavelength data exchange (WDE) is to avoid the introduction of linear and nonlinear phase noise in the subsystem. This is particularly important for phase noise sensitive, high-order quadrature-amplitude modulation (QAM) signals. In this paper, we propose and experimentally demonstrate an optical data exchange scheme through cascaded 2nd-order nonlinearities in periodically-poled lithium niobate (PPLN) waveguides using coherent pumping. The proposed coherent pumping scheme enables noise from the coherent pumps to be cancelled out in the swapped data after WDE, even with broad linewidth distributed feedback (DFB) pump lasers. Hence, this scheme allows phase noise tolerant processing functions, enabling the low-cost implementation of WDE for high-order QAM signals. We experimentally demonstrate WDEs between 10-Gbaud 4QAM (4QAM) signal and 12.5-Gbaud 4QAM (16QAM) signal with 3.5-MHz linewidth DFB pump lasers and 50-GHz channel spacing. Error-free operation is observed for the swapped QAM signals with coherent DFB pumping whilst use of free-running DFB pumps leads to visible error floors and unrecoverable phase errors. The phase noise cancellation in the coherent pump scheme is further confirmed by study of the recovered carrier phase of the converted signals. In addition to pump phase noise, the influence of crosstalk caused by the finite extinction ratio in WDE is also experimentally investigated for the swapped QAM signals.
HeartMate III: Pump Design for a Centrifugal LVAD with a Magnetically Levitated Rotor (2001)

A long-term, compact left ventricular assist device (LVAD), the HeartMate III, has been designed and fabricated, featuring a centrifugal pump with a magnetically levitated rotor. The pump has been optimized by in vitro testing to achieve a design point of 7 L/min against 135 mm Hg at high hydrodynamic efficiency (30%) and to be capable of up to 10 L/min under such a load. Furthermore, the pump has demonstrated no mechanical failures, low hemolysis (4-10 mg/dl plasma free Hb), and low thrombogenicity during six (40, 27, 59, 42, 27, and 49-day) in vivo bovine studies.
Reference-based manga colorization by graph correspondence using quadratic programming (2014)

Manga (Japanese comics) are popular all over the world. However, most existing manga are monochrome. If such monochrome manga can be colorized, readers can enjoy the richer representations. In this paper, we propose a semiautomatic colorization method for manga. Given a previously colored reference manga image and target monochrome manga images, we propagate the colors of the reference manga to the target manga by representing images as graphs and matching graphs. The proposed method enables coloring of manga images without time-consuming manual colorization. We show results in which the colors of characters were correctly transferred to target characters, even those with complex structures.
Quantum dots for biomedical applications (2008)

The use of quantum dots in biomedical applications is accelerating owing to their unique physical attributes, imaging capabilities, and potential for therapeutic delivery.
Splicing mutation in the ATR-X gene can lead to a dysmorphic mental retardation phenotype without alpha-thalassemia. (1996)

We have previously reported the isolation of a gene from Xq13 that codes for a putative regulator of transcription (XNP) and has now been shown to be the gene involved in the X-linked alpha-thalassemia with mental retardation (ATR-X) syndrome. The widespread expression and numerous domains present in the putative protein suggest that this gene could be involved in other phenotypes. The predominant expression of the gene in the developing brain, as well as its association with neuron differentiation, indicates that mutations of this gene might result in a mental retardation (MR) phenotype. In this paper we present a family with a splice junction mutation in XNP that results in the skipping of an exon and in the introduction of a stop codon in the middle of the XNP-coding sequence. Only the abnormal transcript is expressed in two first cousins presenting the classic ATR-X phenotype (with alpha-thalassemia and HbH inclusions). In a distant cousin presenting a similar dysmorphic MR phenotype but not having thalassemia, approximately 30% of the XNP transcripts are normal. These data demonstrate that the mode of action of the XNP gene product on globin expression is distinct from its mode of action in brain development and facial morphogenesis and suggest that other dysmorphic mental retardation phenotypes, such as Juberg-Marsidi or some sporadic cases of Coffin-Lowry, could be due to mutations in XNP.
Percolation Threshold Effects on the Electrical Contact Resistance and Adhesion of Microelectromechanical Systems Thin-Film Materials. (2006)

Abstract not provided.
A Dominant Activating Mutation in the Effector Region of RAS Abolishes IRA2 Sensitivity (1992)

Previously described mutations in RAS genes that cause a dominant activated phenotype affect the intrinsic biochemical properties of RAS proteins, either decreasing the intrinsic GTPase or reducing the affinity for guanine nucleotides. In this report, we describe a novel activating mutation in the RAS2 gene of Saccharomyces cerevisiae that does not alter intrinsic biochemical properties of the mutant RAS2 protein. Rather, this mutation, RAS2-P41S (proline 41 to serine), which lies in the effector region of RAS, is shown to abolish the ability of the IRA2 protein to stimulate the GTPase activity of the mutant RAS protein. This mutation also modestly reduced the ability of the mutant protein to stimulate the target adenylate cyclase in an in vitro assay, although in vivo the phenotypes it induced suggest that it retains potency in stimulation of adenylate cyclase. Our results demonstrate that although the effector region of RAS appears to be important for interaction with both target effector and negative regulators of RAS, it is possible to eliminate negative regulator responsiveness and retain potency in effector stimulation.
Generation of Blood Cells from Human Ips Cells in Vitro through the Hematopoietic Progenitors Concentrated within the Unique Structures, Ips-Sac. (2008)

Abstract Human embryonic stem cells (hESCs) are proposed as an alternative source for transfusion therapy or studies of hematopoiesis. We have recently established an in vitro culture system whereby hESCs can be differentiated into hematopoietic progenitors within the ‘unique sac-like structures’ (ES-sacs), that are able to produce megakaryocytes and platelets (Takayama et al., Blood, 111, 5298–306, 2008). However there is a little concern that repetitive transfusion with same human ESC-derived platelets may induce immunological rejection against transfused platelets expressing allogenic HLA. Meanwhile, induced pluripotent stem (iPS) cells established from donor with identical HLA are well known as a potential and given source on platelet transfusion devoid of rejection. To examine if human iPS cells could generate platelets as well as from hESCs, we utilized 3 different human iPS cell lines; two were induced by transduction of 4 genes (Oct3/4, Klf4, Sox2, and c-Myc) in adult dermal fibroblasts, and one was by 3 genes without c-Myc. Sac-like structures (iPS-sac), inducible from 3 iPS cell lines, concentrated hematopoietic progenitors that expressed early hemato-endothelial markers, such as CD34, CD31, CD41a (integrin αIIb) and CD45. These progenitors were able to form hematopoietic colonies in semi-solid culture and differentiate into several blood cells including leukocytes, erythrocytes or platelets. Of these, obtained platelets responded to agonist stimulation, in which the function was as much as human ESC-derived platelets, as evidenced by PAC-1 binding with activated αIIbβ3 integrin or full spreading onto fibrinogen. These results collectively indicated that human dermal fibroblasts could generate functional and mature hematopoietic cells through the reprogramming process and this method may be useful for basic studies of hematopoietic disorders and clinical therapy in the future.
Learning probabilistic neural representations with randomly connected circuits (2020)

The brain represents and reasons probabilistically about complex stimuli and motor actions using a noisy, spike-based neural code. A key building block for such neural computations, as well as the basis for supervised and unsupervised learning, is the ability to estimate the surprise or likelihood of incoming high-dimensional neural activity patterns. Despite progress in statistical modeling of neural responses and deep learning, current approaches either do not scale to large neural populations or cannot be implemented using biologically realistic mechanisms. Inspired by the sparse and random connectivity of real neuronal circuits, we present a model for neural codes that accurately estimates the likelihood of individual spiking patterns and has a straightforward, scalable, efficient, learnable, and realistic neural implementation. This model's performance on simultaneously recorded spiking activity of >100 neurons in the monkey visual and prefrontal cortices is comparable with or better than that of state-of-the-art models. Importantly, the model can be learned using a small number of samples and using a local learning rule that utilizes noise intrinsic to neural circuits. Slower, structural changes in random connectivity, consistent with rewiring and pruning processes, further improve the efficiency and sparseness of the resulting neural representations. Our results merge insights from neuroanatomy, machine learning, and theoretical neuroscience to suggest random sparse connectivity as a key design principle for neuronal computation.
Host as the Variable: Model Hosts Approach the Immunological Asymptote (2005)

There is currently great interest in studying the interaction of nonmammalian hosts with microbes that are pathogenic to mammals. In recent years, numerous studies have reported the outcome of human pathogenic microbe interactions with such nonmammalian hosts as amoebae, slime molds, plants, worms, fish, and insects (18, 20, 24, 27, 32, 34). This trend is fueled by many forces, including the precedent established by the discovery of Toll receptors in flies (3), the realization that microbial virulence mechanisms are often shared and conserved among very different types of hosts (26), the suggestion that for certain microbes mammalian virulence may originate from interactions with nonmammalian hosts in the environment (7, 34), the attraction of simpler host-microbe systems with well-developed genetic tool boxes (32), fewer restrictions on the use of nonvertebrate hosts, and scientific curiosity about the extent to which host-microbe interactions are common. In this issue, we are presented with a timely Minireview on worms and flies as model hosts (20) and the description of yet another model host system for the study of fungal pathogenesis using moths (23). Clearly, the study of model hosts is a powerful tool in microbial pathogenesis; yet, their use poses questions that range from the proper lexicon to the justification for this type of scientific inquiry.
Feasibility of Cosmic Object Detection Using a Solar FSR System (2019)

The article analyses the possibility of the forward scatter radar method for detecting large-sized cosmic objects when using emission of the Sun as probing signals. The method of the forward scatter radar is based on the phenomenon of a significant increase the bistatic target radar cross section when the probe signal is scattered forward, i.e. along direction of the principal beam of locator pattern.
The Symbolic Structure of La Chanson de Roland (1950)

Critics and scholars have for years been aware that one of the characteristic devices of the author of the Chanson de Roland is his use of a three-fold rhythm in the development of the story. By this term they have meant that the usual practice of coincidence of episode with strophe, or laisse , is not observed. Instead of using one laisse for one incident or unit of an incident, as was customary in epic style, the author employs occasionally what is called laisses similaires , or strophes where the action or incident is repeated in a second or sometimes a third strophe with a slightly different wording. Anyone who has read the Chanson de Roland will have noticed these repetitive stanzas and most commentators of the poem have called attention to them. Not a few scholars have gone into the history of this device, but its aesthetic purpose has been glossed over in rather general terms.
Synergistic effects of LTC4 and TxA2 on coronary flow and myocardial function (1988)

Accumulation of leukocytes and platelets in the injured myocardium may influence coronary arteriolar resistance via release of peptidoleukotrienes and thromboxane A2 (TxA2). Although leukotriene C4 (LTC4) and TxA2 individually reduce coronary blood flow, the effects of their simultaneous administration are not known. Accordingly, the combined effects of intracoronary administration of synthetic LTC4 and thromboxane "mimic" U 46619 on coronary blood flow in patent and severely narrowed coronary arteries and myocardial segmental function were examined in eight anesthetized dogs. Administration of LTC4 and U 46619 (0.3-3 micrograms) showed concentration-dependent reductions in coronary blood flow and myocardial segment shortening. When these eicosanoids (3 micrograms each) were administered in close sequence, coronary blood flow decreased 33% in the patent artery and 47% in the narrowed artery. This reduction in coronary blood flow in the narrowed coronary artery produced a 26% decrease in myocardial segment shortening. Reductions in narrowed coronary artery blood flow and myocardial segment shortening were greater than the sum of changes caused by LTC4 and U 46619 administered separately (P less than 0.05). The histopathology of the narrowed coronary artery revealed endothelial disruption at the site of occlusion and an in vivo thrombus just distal to the site of occlusion. These data suggest marked synergism between the actions of LTC4 and TxA2, which may be released locally at the site of coronary thrombus, on blood flow in a severely narrowed coronary artery, and on segmental function in the region supplied by this vessel.
Synthesis, Biological Activity, and Crystal Structure of Potent Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase That Retain Activity against Mutant Forms of the Enzyme (2007)

In an ongoing effort to develop novel and potent nonnucleoside HIV-1 reverse transcriptase (RT) inhibitors that are effective against the wild type (WT) virus and clinically observed mutants, 1,2-bis-substituted benzimidazoles were synthesized and tested. Optimization of the N1 and C2 positions of benzimidazole led to the development of 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methylbenzimidazole (1) (IC50 = 0.2 microM, EC50 = 0.44 microM, and TC50 >/= 100 against WT). This paper describes how substitution on the benzimidazole ring profoundly affects activity. Substituents at the benzimidazole C4 dramatically enhanced potency, while at C5 or C6 substituents were generally detrimental or neutral to activity, respectively. A 7-methyl analogue did not inhibit HIV-1 RT. Determination of the crystal structure of 1 bound to RT provided the basis for accurate modeling of additional analogues, which were synthesized and tested. Several derivatives were nanomolar inhibitors of wild-type virus and were effective against clinically relevant HIV-1 mutants.
Cytokine-Induced Killer Cells Engineered with Exogenous T-Cell Receptors Directed Against Melanoma Antigens: Enhanced Efficacy of Effector Cells Endowed with a Double Mechanism of Tumor Recognition (2015)

Cytokine-induced killer (CIK) cells consist of a heterogeneous population of polyclonal T lymphocytes displaying NK phenotype and HLA-unrestricted cytotoxic activity against a broad range of tumors. We sought to determine whether transduction of CIK cells with T cell receptor (TCR) genes specific for tumor-associated antigens could generate effector cells endowed with a double mechanism of tumor recognition. HLA-A2-restricted TCR-transduced (TD) CIK directed against the melanoma antigens Mart1 and NY-ESO1 were generated by lentiviral transduction and successfully expanded over a 3-4-week period. TD-CIK cells were both CD3(+)/CD56(-) and CD3(+)/CD56(+) (31±8% and 59±9%, respectively), indicating that both major histocompatibility complex (MHC)-restricted T cells and MHC-unrestricted CIK could be targeted by lentiviral transduction. At the end of the culture, the majority of both unmodified and TD-CIK displayed an effector memory phenotype, without considerable expression of replicative senescence and exhaustion markers. Functionally, TD-CIK specifically recognized tumor cells expressing the relevant antigen as well as maintained their MHC-unrestricted tumor activity. The cytotoxic activity of TD-CIK against HLA-A2(+) melanoma cell lines was significantly higher than the untransduced counterparts at a low effector:target ratio (cytotoxic activity of TD-CIK was from 1.9- to 4.3-fold higher than untransduced counterparts). TD-CIK were highly proficient in releasing high amount of IFN-γ upon antigen-specific stimulation and were able to recognize primary melanoma targets. In conclusion, we showed that (1) the reproducibility and simplicity of CIK transduction and expansion might solve the problem of obtaining adequate numbers of potent antitumor effector cells for adoptive immunotherapy; (2) the presence of both terminal effectors as well as of less differentiated progenitors might confer them long survival in vivo; and (3) the addition of an MHC-restricted antigen recognition allows not only targeting tumor surface antigens but also a wider range of cytoplasmic or nuclear antigens, involved in tumor proliferation and survival. TD-CIK cells with a double mechanism of tumor recognition are an attractive and alternative tool for the development of efficient cell therapeutic strategies.
Electromagnet design allowing explicit and simultaneous control of minimum wire spacing and field uniformity (2012)

Abstract An adaptive algorithm is presented that works to independently and explicitly control both local power deposition and magnetic field uniformity in a robust, automated manner. The only inputs to the algorithm are the minimum allowable wire spacing, the maximum allowable field error, and the geometry over which to produce the coil. To highlight the function of the algorithm, two examples are investigated: a transverse gradient coil insert, designed for imaging the head and neck; and a highly uniform, low‐power, B 0 field coil. Both examples require highly optimized relative weighting between power dissipation and field uniformity. The algorithm is described and implemented in terms of the boundary element method for coil design. The algorithm is shown to produce acceptable designs; conforming to engineering constraints, for both instances within a matter of minutes. © 2012 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 41B: 120–129, 2012
Surface plasmon isolator based on nonreciprocal coupling (2009)

Integrated photonics require optical isolators that achieve low insertion loss and large optical isolation. Here we describe a surface plasmon enhanced optical isolator based on nonreciprocal coupling from a dielectric waveguide coupled to a surface plasmon waveguide. The surface plasmon core consists of a magnetic metal which results in a large nonreciprocity, allowing for device lengths on the order of 50 μm. The analysis and modeling presented here indicate that greater than 30 dB isolation and less than 3 dB insertion loss are possible.
The SGN comparative map viewer (2008)

With the rapid accumulation of genetic data for a multitude of different species, the availability of intuitive comparative genomic tools becomes an important requirement for the research community. Here we describe a web-based comparative viewer for mapping data, including genetic, physical and cytological maps, that is part of the SGN website (http://sgn.cornell.edu/) but that can also be installed and adapted for other websites. In addition to viewing and comparing different maps stored in the SGN database, the viewer allows users to upload their own maps and compare them to other maps in the system. The viewer is implemented in object oriented Perl, with a simple extensible interface to write data adapters for other relational database schemas and flat file formats.
Some peculiar properties of the MDCT (2002)

Having established the interconnection between MDCT, SDFT (shifted discrete Fourier transform) and DFT, we have successfully applied the results in audio encoder design. This paper presents some new observations and analyses: (1) MDCT is not an orthogonal transform and this has an impact on audio coding, and (2) analysis of time domain alias cancellation (TDAC) during the window switching in the case of MPEG-2 AAC. Finally, we report some experimental results on the energy compaction properties of MDCT.
Management of Pediatric Supracondylar Humerus Fractures With Vascular Injury (2016)

The American Academy of Orthopaedic Surgeons has developed the Appropriate Use Criteria (AUC) document Management of Pediatric Supracondylar Humerus Fractures With Vascular Injury. Evidence-based information, in conjunction with the clinical expertise of physicians, was used to develop the criteria to improve patient care and obtain the best outcomes while considering the subtleties and distinctions necessary in making clinical decisions. The AUC clinical patient scenarios were derived from patient indications that generally accompany a pediatric supracondylar humerus fracture with vascular injury, as well as from current evidence-based clinical practice guidelines and supporting literature. The 6 patient scenarios and 18 treatments were developed by the Writing Panel, a group of clinicians who are specialists in this AUC topic. Next, the Review Panel, a separate group of volunteer physicians, independently reviewed these materials to ensure that they were representative of patient scenarios that clinicians are likely to encounter in daily practice. Finally, the multidisciplinary Voting Panel (made up of specialists and nonspecialists) rated the appropriateness of treatment of each patient scenario using a 9-point scale to designate a treatment as Appropriate (median rating, 7 to 9), May Be Appropriate (median rating, 4 to 6), or Rarely Appropriate (median rating, 1 to 3).