gebhart/patrepeval huggingface dataset:
Simulation, optimization, and fabrication of optical micro microresonator based lasers and filters, and coupling to radial or tangential waveguides (2011)

Microdisk, Microring, Microcylinder, and various curvilinear-shape optical resonators with sizes from submicron to hundreds of microns have become a widely used technology. We refer to them collectively as optical microresonators. These optical microresonators can be used as highly compact tunable optical filters integrated on chip. They can also be used to form wavelength-scale optical cavities for realizing microcavity lasers and various microcavity devices. There are few systematic studies of the limitations of these microresonators. Knowing their limitations is important for various practical applications. We first review the various progresses in these optical microresonators, followed by a discussion of the main factors affecting the cavity Q factor of these microresonators. To understand radiation loss, we show a numerically accurate method to compute the radiation loss using conformal transformation. We discuss how to simulate lasing properties of these optical microresonators by using a multi-level multi-electron Finite-Difference Time-Domain (MLME FDTD) quantum model for the semiconductor medium. We then discuss how to compute radiation loss and scattering loss using a FDTD method based on an active-lasing approach and to compare the results to the conformal transformation results. Lastly, we address the important question of how to optimize output coupling of the lasing light in these optical resonators utilizing either a conventional tangential waveguide coupling method or a novel radial waveguide coupling method.
Preparation, characterization, and photoswitching/light-emitting behaviors of coronene nanowires (2010)

Coronene nanowires were prepared through the reprecipitation method. The as-prepared one-dimensional (1D) nanostructures were characterized by UV-vis, fluorescence spectra, X-ray diffraction (XRD), optical microscopy, field emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM). We found that coronene nanowires in aqueous solution emitted strong green light instead of blue light for coronene molecules in THF solution. Moreover, the thin film of coronene nanowires on rGO/SiO2/Si electrode produced a strong photocurrent response upon irradiation. In addition, a heterojunction light emitting diode (LED) device with the structure of quartz/ITO/p-coronene nanowires/n-SiC/Ti (10 nm)/Au (120 nm) has been fabricated. The strong electroluminescence (EL) emission centered at ∼430 nm was detected with a forward bias at 20 V. Our result showed that the use of organic nanowires as the p-type hole injection layer could produce diodes with performance better than those with only inorganic thin-film structures.
Torsion balances, torsion pendulums, and related devices (1993)

The torsion pendulum is not only a mainstay instrument in the world of precision measurement and gravitational physics, but is important in electrical science, biophysics, petrology, metallurgy, and various other fields of endeavor. Whether used in the ‘‘static’’ (deflection) mode, the ‘‘dynamic’’ (oscillating) mode, or in some more complex configuration, instrumentation of this kind enables one to isolate and measure weak effects that would otherwise be difficult if not impossible to observe against the background gravitational field of the earth. In this review, we present a brief history of fiber-suspended apparatus and assess the fundamental limits of performance of the dumbbell pendulum. We then inventory the different versions of such systems presently used by gravitational physicists and discuss the various interrogation techniques used to monitor the movement of the suspended test mass. Next, we tabulate some of the applications for torsion instruments outside of gravitational physics, and close with a few comments on the direction of research in this area.
BNT162b2 vaccine-induced humoral and cellular responses against SARS-CoV-2 variants in Systemic Lupus Erythematosus (2021)

ABSTRACT Objectives Our aims were to evaluate Systemic Lupus Erythematosus (SLE) disease activity and SARS-CoV-2 specific immune responses after BNT162b2 vaccination. Methods In this prospective study, disease activity and clinical assessments were recorded from the first dose of vaccine, until day 15 after the second dose in 126 SLE patients. SARS-CoV-2 antibody responses were measured against wild-type spike antigen while serum-neutralizing activity was assessed against the SARS-CoV-2 historical strain and variants of concerns (VOCs). Vaccine-specific T-cell responses were quantified by Interferon (IFN)-γ release assay after the second dose. Results BNT162b2 was well tolerated and no statistically significant variations of BILAG and SLEDAI scores were observed throughout the study in SLE patients with active and inactive disease at baseline. Mycophenolate Mofetil (MMF) and Methotrexate (MTX) treatments were associated with drastically reduced BNT162b2 antibody-response (β=-78; p=0.007, β=-122; p&lt;0.001, respectively). Anti-spike antibody response was positively associated with baseline total IgG serum levels, naïve B cell frequencies (β=2; p=0.018, β=2.5; p=0.003) and SARS-CoV-2-specific T cell response (r=0.462; p=0.003). In responders, serum neutralization activity decreased against VOCs bearing the E484K mutation but remained detectable in a majority of patients. Conclusion MMF, MTX and poor baseline humoral immune status, particularly: low naïve B cell frequencies, are independently associated with impaired BNT162b2 mRNA antibody response, delineating SLE patients who might need adapted vaccine regimens and follow-up. KEY MESSAGES What is already known about this subject? BNT162b2 efficacy and safety has been described in studies mixing different RMDs What does this study add? No serious adverse effects, nor SLE flares have been documented after BNT162b2 in SLE patients. Not only MMF and MTX, but also a poor humoral immune status at baseline impair vaccine antibody response Albeit decreased, serum neutralizing activity against VOCs is conferred to vaccine-responders. How might this impact on clinical practice or future developments? These parameters could be helpful for physicians to delineate which patients should have antibody measurement after full BNT162b2 vaccination and should be proposed a third injection of BNT162b2 vaccine.
Link Foundation Fellowship Final Report (2008)

Martinson, Alex. (2008). Link Foundation Fellowship Final Report.(Link Foundation Fellowship Final Reports: Energy Program.) Retrieved from The Scholarship Repository of Florida Institute of Technology website : https://repository.lib.fit.edu/.
Reply to van de Sandt and Rimmelzwaan: Matching epitope display with functional avidity (2015)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Configurational effects on shock wave propagation in Ni-Al multilayer composites (2012)

The shock compression response of cold-rolled Ni and Al multilayered composites at various angles of inclination are investigated by employing meso-scale simulations. The orientation of the laminate layers in the multilayered composite is varied at 0°, 45°, and 90° to the direction of shock front propagation to determine and understand the resulting changes in the shock compression response. Real, heterogeneous microstructures, obtained from optical micrographs of the multilayered composite cross-section, are incorporated into the Eulerian, finite volume code, CTH. The simulations are performed to establish the role that the orientation of material interfaces plays in the dispersion and dissipation of the shock wave as well as the US-UP relationship for each configuration. Noticeable differences are observed at the meso-scale in the pressure, temperature, and strain response, as a function of the underlying microstructure. Geometric dispersion is seen to alter the shape of the resulting pressure pulse and inhibit the development of a steady-state shock wave in the laminate geometry. This effect is heightened by the extensive non-uniformities of the layering caused by cold-rolling. Additionally, two-dimensional effects of strain are seen to increase the dissipation of the shock wave through interfacial heating and shearing, resulting in high levels of viscosity and attenuation. While the effects of dispersion are minimal on the bulk response of the multilayered composite, the high rate of dissipation is seen to change the dependence of the shock velocity on the particle velocity, making dissipation a major contributor to the bulk response of these composites under shock compression.
Nonlinear Enhancement with Graphene Heterostructures (2019)

Nonlinear nanoplasmonics provides precise control and manipulation of light. Graphene sustains electrically tunable and long-lived plasmons. By combining these platforms, we observe a 102 enhancement in the third-harmonic generation in graphene heterostructures.
Some Issues in Design of Data Warehousing Systems (2001)

Information is one of the most valuable assets of an organization, and when used properly can assist intelligent decision-making that can significantly improve the functioning of an organization. Data warehousing is a recent technology that allows information to be easily and efficiently accessed for decision-making activities. On-line analytical processing (OLAP) tools are well studied for complex data analysis. A data warehouse is a set of subject-oriented, integrated, time varying and non-volatile databases used to support the decision-making activities (Inmon, 1992).
Bimetal atom chemistry. 2. Selective bimetallic photoaggregation of silver and chromium atoms to very small clusters, CrnAgm (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBimetal atom chemistry. 2. Selective bimetallic photoaggregation of silver and chromium atoms to very small clusters, CrnAgmGeoffrey A. Ozin and Werner E. KlotzbuecherCite this: Inorg. Chem. 1979, 18, 8, 2101–2108Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/ic50198a009https://doi.org/10.1021/ic50198a009research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Necrosis Gene-Based Monitoring and Control of Potato Scab Disease (2007)

The efficacy of a scab disease control technique that combined an antagonistic microorganism (Trichoderma asperellum strain F-288) and fertilization amelioration was examined by determining the incidence of scab disease and by using quantitative competitive quenching probe PCR (QCQP-PCR) to determine the copy number of the nec1 gene in soil. We conducted the nec1 gene analysis and a planter experiment with red-yellow soil specimens collected from the Shimabara Peninsula of Nagasaki Prefecture, Japan. The results of the planter experiment suggested the possibility of inhibiting the development of potato scab disease using an antagonistic microorganism alone for soil with a low initial copy number of the nec1 gene, and using a combination of an antagonistic microorganism and fertilization amelioration for soil with a high initial copy number. We conducted research on the relationship between the copy number of nec1 in the soil and the concentration in soil of aqueous aluminum ions, an inhibitory agent of common scab disease in fertilization amelioration. The result suggested that the incidence of the disease could be reduced if the concentration of aqueous aluminum ions in the soil was 0.1 mg/L or more.
Supplemental Figure 2 from Novel Methylated DNA Markers in the Surveillance of Colorectal Cancer Recurrence (2023)

&lt;p&gt;Supplemental Figure 2: The importance of individual MDMs and CEA in contribution to the performance of random forest model in classification of early CRC from healthy control in MDM Plasma CRC Early Primary Detection Study. MDM: methylated DNA marker; CEA: carcinoembryonic antigen; CRC: colorectal cancer.&lt;/p&gt;
An Integrated High Throughput Experimentation/Predictive QSAR Modeling Approach to ansa-Zirconocene Catalysts for Isotactic Polypropylene (2020)

Compared to heterogenous Ziegler-Natta systems (ZNS), <i>ansa</i>-metallocene catalysts for the industrial production of isotactic polypropylene feature a higher cost-to-performance balance. In particular, the <i>C</i><sub>2</sub>-symmetric <i>bis</i>(indenyl) <i>ansa</i>-zirconocenes disclosed in the 1990s are complex to prepare, less stereo- and/or regioselective than ZNS, and lose performance at practical application temperatures. The golden era of these complexes, though, was before High Throughput Experimentation (HTE) could contribute significantly to their evolution. Herein, we illustrate a Quantitative Structure - Activity Relationship (QSAR) model trained on a robust and highly accurate HTE database. The clear-box QSAR model utilizes, in particular, a limited number of chemically intuitive 3D geometric descriptors that screen various regions of space in and around the catalytic pocket in a modular way thus enabling to quantify individual substituent contributions. The main focus of the paper is on the methodology, which should be of rather broad applicability in molecular organometallic catalysis. Then again, it is worth emphasizing that the specific application reported here led us to identify in a comparatively short time novel zirconocene catalysts rivaling or even outperforming all previous homologues which strongly indicates that the metallocene story is not over yet.
An improved synthesis of 6-amino-1,2,3,4-tetrahydro-2-methylisoquinoline: elucidation of the stereochemistry of some diastereoisomers of 6-amino-2-methyldecahydroisoquinoline (1976)

An improved synthesis of 6-amino-1,2,3,4-tetrahydro-2-methylisoquinoline is reported, along with the synthesis, isolation, and elucidation of the stereochemistry of three of the four possible diastereoisomers of the previously unreported 6-amino-2-methyldecahydroisoquinoline. Stereochemical assignments were made from a combination of chemical evidence, involving conversion of the amines into the corresponding known alcohols and oxidation of the alcohols to the corresponding ketones, and spectral data.
A New Class of Improved Bandwidth Planar Ultrawideband Modular Antenna (puma) Arrays Scalable to mm-Waves (2023)

A new class of Planar Ultrawideband Modular Antenna (PUMA) arrays, termed PUMAv3, is introduced to offer improved performance and further meet demand needs for multifunctional systems. PUMAv3 extends the frequency scalability of PUMA arrays to mm-waves (approximately 50 GHz) and improves bandwidth by 50\\% without the use of a matching network or external baluns. The major enabling technical innovation is the advent of a new common-mode mitigation mechanism that relies upon capacitively-loaded shorting vias to push broadside catastrophic resonances below the operating band without inhibiting low-end bandwidth performance. Ridged waveguide models are employed to explain the operational principles and accurately predict the location of the common-mode frequency within the new array topology. Additionally, the superstrate loading scheme is split into two exclusive layers to enhance broadside and wide angle impedance levels while maintaining the highest frequency at 97% of the grating lobe frequency and reducing the overall array profile by up to 30%. The PUMAv3 also retains the attractive practical advantages inherent to the PUMA array family: aperture modularity, direct 50-ohm feeding, and low-cost planar multilayer PCB fabrication. Infinite array full-wave simulations of a dual-polarized PUMAv3 satisfying manufacture guidelines suggest 10.6-47.6 GHz (4.5:1) operation with strong VSWR levels out to 45 degrees, high port isolation and low cross-polarization.
Fabrication and Characterization of ZrO2/AlGaN/GaN MIS-HEMTs with regrown AlGaN Layer (2021)

We have fabricated and characterized ZrO2/AlGaN/GaN MIS-HEMTs with a 1-nm-thick AlGaN layer regrown on top of the original AlGaN barrier layer. Capacitance-voltage characteristics revealed spill-over phenomenon, suggesting good quality of the resulting ZrO2/regrown-AlGaN interface. From the transfer characteristics, maximum drain current of 1100 mA/mm and maximum transconductance of 102 mS/mm were obtained.
Topical Antimicrobials for Burn Wound Infections (2010)

Throughout most of history, serious burns occupying a large percentage of body surface area were an almost certain death sentence because of subsequent infection. A number of factors such as disruption of the skin barrier, ready availability of bacterial nutrients in the burn milieu, destruction of the vascular supply to the burned skin, and systemic disturbances lead to immunosuppression combined together to make burns particularly susceptible to infection. In the 20th century the introduction of antibiotic and antifungal drugs, the use of topical antimicrobials that could be applied to burns, and widespread adoption of early excision and grafting all helped to dramatically increase survival. However the relentless increase in microbial resistance to antibiotics and other antimicrobials has led to a renewed search for alternative approaches to prevent and combat burn infections. This review will cover patented strategies that have been issued or filed with regard to new topical agents, preparations, and methods of combating burn infections. Animal models that are used in preclinical studies are discussed. Various silver preparations (nanocrystalline and slow release) are the mainstay of many approaches but antimicrobial peptides, topical photodynamic therapy, chitosan preparations, new iodine delivery formulations, phage therapy and natural products such as honey and essential oils have all been tested. This active area of research will continue to provide new topical antimicrobials for burns that will battle against growing multidrug resistance.
P-137 Safety of Adalimumab in Global Clinical Trials of Ulcerative Colitis Patients (2013)

The safety profile of adalimumab (ADA) has been previously reported for the double-blind (DB) pivotal trials ULTRA 1 and ULTRA 2 in patients (pts) with moderate to severe ulcerative colitis (UC).1,2 Safety data from the ongoing open-label extension (OLE) continue to be collected. All patients participating in ULTRA 1, ULTRA 2, and OLE had regular safety evaluations. Rates of adverse events (AEs) of interest were assessed per 100 patient-years (PY) of exposure. Event rates were calculated for placebo (PBO) and ADA during the DB period (up to week 52) from ULTRA 1 (160/80 mg dose group only) and ULTRA 2 and through 15 April 2012 for any ADA exposure (ULTRA 1, ULTRA 2, or the OLE). As of 15 Apr 2012, 1010 pts had received ADA for UC, totaling 2007.4 PY of exposure. AE rates observed during DB treatment and up to the 15 April 2012 update are shown (Table). A similar overall rate of AEs was observed during DB treatment between PBO and ADA. Serious AEs, serious infections, AEs leading to discontinuation, and UC worsening/flare were more frequent with PBO, whereas opportunistic infections, injection site reactions, and hepatic events were more frequent with ADA. AE rates during any ADA exposure were consistent with rates previously reported for ADA and other anti-TNFs in CD.3,4 The safety profile and AE rates observed with long-term ADA exposure (up to 4 yrs) in UC were similar to those occurring during DB therapy. No new safety signals were identified. References: 1. Reinisch, et al. 2011. Gut;60:780. 2. Sandborn, et al. 2012. Gastroenterology;142:257. 3. Colombel, et al. 2009. Inflamm Bowel Dis;5:1308. 4. Lichtenstein, et al. 2012. Am J Gastroenterol;107:1409.
A nonlinear lag correction algorithm for a‐Si flat‐panel x‐ray detectors (2012)

The NLCSC lag algorithm corrected for the exposure dependence of lag, provided superior image improvement for the pelvic phantom reconstruction, and gave similar results to the best case LTI results for the head phantom. The blurred ring artifact that is left over in the LTI corrections was better removed by the NLCSC correction in all cases.
Synthesis of nitrogen heterocycles via the intramolecular [4+2] cycloaddition of iminoacetonitriles (2003)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2003.
Cosolvent (2016)

This Glossary of Terms Related to Pharmaceutics is needed by practitioners in the field of pharmaceutics as this field fulfills an important and crucial role, different from the roles of other scientific disciplines involved in the drugmaking process. The glossary contains 168 definitions used in pharmaceutics. These are related to various aspects of this discipline, such as: (1) physicochemical characterization of pharmaceutical preparations and the active ingredients they contain; (2) unit operations used in the practice of pharmaceutics; (3) terms related to the various dosage forms; (4) terms related to the various modes and routes of drug delivery; (5) terms used in pharmacokinetics and biopharmaceutics in general; and additional miscellaneous terms. The field of pharmaceutics itself is of a multidisciplinary nature as its practitioners come from a variety of disciplines, such as chemistry or various biological sciences, thus a glossary containing authoritative definitions would be useful for them. The terms used in pharmaceutics are rarely covered by existing glossaries, and in the cases they are, their definitions are often inappropriate for the field of pharmaceutics and require new or modified definitions to better fit the new context.
Reconstructing Integrin Activation In Vitro (2013)

Integrin activation leads to an increased affinity for the extracellular matrix and regulates many cellular processes such as cell adhesion and migration. To capture the process of integrin inside-out activation in a purified system, we describe here methods to isolate platelet αIIbβ3 integrins in the inactive state and to incorporate them into phospholipid nanodiscs each bearing a single lipid-embedded αIIbβ3 integrin. We delineate a simple enzyme-linked immunosorbent assay that can be used in conjunction with binding of an activation specific monoclonal antibody, PAC1, to monitor the affinity of the integrin before and after the addition of activators such as the Talin Head Domain (THD). The system has been used to show that binding of the THD to both the integrin and the phospholipid bilayer is necessary and sufficient to activate and promote molecular extension of unclustered integrins in the absence of force. This method can be used to test various integrin-binding proteins, membrane phospholipid compositions and different types of integrins. It can also serve as the nidus for synthetic assembly of adhesion plaque like complexes from purified proteins.