gebhart/patrepeval huggingface dataset:
Minimally cultured bone marrow mesenchymal stem cells ameliorate fibrotic lung injury (2009)

Clinical use of bone marrow mesenchymal stem cells (BMMSCs) holds great promise for regenerative medicine in intractable lung diseases, such as lung fibrosis or acute respiratory distress syndrome. However, a severe obstacle to the clinical application of BMMSC transplantation is the time-consuming, laborious processes required for cell culture. In order to evaluate the clinical applicability of BMMSC transplantation, we tested whether engraftment of minimally cultured BMMSCs ameliorates progressive fibrotic lung injury. Differences between murine BMMSCs cultured for 2 h (2-h adherent BMMSCs) and conventionally (9-day) cultured BMMSCs were examined in vitro. The effects of grafting either type of BMMSCs on fibrotic lung injury were then assessed by transfer experiments in a murine bleomycin-induced lung fibrosis model, in which donor cells were administered 3 days after challenge. 2-h adherent BMMSCs were smaller, less granular, possessed higher proliferative capacity and expressed higher levels of several stem cell markers and chemokine receptors than 9-day cultured BMMSCs, but lower type I procollagen, alpha-smooth muscle actin, tumour necrosis factor-beta and oncogenic transcription factor c-Myc, suggesting that they may be advantageous for cell-based therapy compared with 9-day cultured BMMSCs. Grafting 2-h adherent BMMSCs ameliorated inflammatory and fibrotic lung disorders, and reduced mortality equally well or better than 9-day cultured BMMSCs. Minimally cultured BMMSCs can substitute for conventionally cultured BMMSCs and will be a promising cell source for the treatment of acute fibrotic lung injury.
Microfluidic jet injection for delivering macromolecules into cells (2013)

We present a microfluidic-based injection system designed to achieve intracellular delivery of macromolecules by directing a picoliter jet of a solution toward the individual cells. After discussing the concept, we present design specification and criteria, elucidate performance and discuss results. The method has the potential to be quantitative and of high throughput, overcoming the limitations of current intracellular delivery protocols.
Shaping the Future of Personalized Nutrition with Metabolomics (2013)

Nutrition represents the strongest lifelong environmental determinant of human health. Modern nutrition research aims at improving health status of individuals through providing new tailored dietary and lifestyle solutions. This concept of personalized nutrition implies a deep knowledge of the complex molecular interplay between genetic makeup and environmental factors including nutrition, metabolism, and food in individual or group of consumers. The discipline of metabolomics is particularly well suited to address this scientific challenge, thanks to its ability to measure the real endpoints of the physiological regulatory processes of living organisms. Furthermore, metabolomics offers the possibility to generate a new generation of biomarkers of health status and nutrition effects at the system level. Nutritional metabolomics employs the metabolic analysis of biological samples mainly using two analytical techniques based on nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) coupled either to gas or liquid chromatography (GC?MS and LC?MS). NMR spectroscopy offers the unique prospect to holistically profile hundreds of metabolites without any preselection. MS methods are also commonly employed for global and targeted profiling with well-adapted sample preparation. MS can generate comprehensive metabolic profiles across chemically diverse classes of compounds including lipids (lipidomics), amino acids biogenic amines, and others. This chapter will review applications and challenges of NMR- and MS-assisted metabolomics for personalized nutrition.
Chiral synthesis via organoboranes. 6. Asymmetric allylboration via chiral allyldialkylboranes. Synthesis of homoallylic alcohols with exceptionally high enantiomeric excess (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChiral synthesis via organoboranes. 6. Asymmetric allylboration via chiral allyldialkylboranes. Synthesis of homoallylic alcohols with exceptionally high enantiomeric excessPrabhakar K. Jadhav, Krishna S. Bhat, P. Thirumalai Perumal, and Herbert C. BrownCite this: J. Org. Chem. 1986, 51, 4, 432–439Publication Date (Print):February 1, 1986Publication History Published online1 May 2002Published inissue 1 February 1986https://doi.org/10.1021/jo00354a003RIGHTS & PERMISSIONSArticle Views4112Altmetric-Citations326LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Constitutive Bcl-2 over-expression triggers an anabolic response in chondrocytes, with partial abatement of IL-1&#x03B2; catabolic effects (2009)

We are interested in engineering cartilage that is resistant to arthritic disease. We hypothesized that suppression of terminal differentiation pathways would lead to decreased chondrocyte catabolic response to inflammatory cytokines and used a Bcl-2 over-expression gene therapy approach targeting chondrocyte apoptosis. Retrovirally transduced chondrocytes were cultured in 1.25% alginate hydrogels and subjected to interleukin 1beta (IL-1beta) stimulation (5 ng/ml) over one month. In the absence of IL-1beta, Bcl-2 therapy induced a pro-chondrogenic effect, increasing anabolic gene expression and glycosaminoglycan (GAG) accumulation while decreasing injury markers. Though Bcl-2 continued to increase anabolic markers and tissue inhibitors of matrix metalloproteinases (MMPs) under IL-1beta stimulation, it did not override the overall IL-1beta suppression of cell number and anabolic markers. Bcl-2 further augmented MMP expression and total GAG loss with IL-1beta. However under long term IL-1beta stimulation, Bcl-2 abrogated the expression of hypertrophic markers such as collagen type X. Thus, elucidation of the mechanism driving the beneficial aspects of Bcl-2 over-expression and developing conditionally regulated anti-apoptotic gene therapy may prove therapeutic in engineering cartilage that is resistant to disease.
The Effect of Transcutaneous Spinal Cord Stimulation on Standing Postural Control in Healthy Adults (2022)

<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Aim:</i> To determine the effects of pulsed current transcutaneous spinal cord stimulation (TSCS) on both the spinal circuitry and the neuromotor response observed after a trunk force perturbation. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Methods:</i> A group of young healthy adults performed two experiments to study the effects of TSCS. In experiment I, the effect of TSCS on the spinal circuitry was assessed using the Hoffman-reflex (H-reflex) recruitment curve and recovery cycle. In Experiment II, the effect of TSCS on the response to trunk force perturbation was assessed with both stimulation on and off. The force perturbations were delivered by the robotic upright trunk support trainer (RobUST). <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Results:</i> 30 Hz monophasic pulsed current TSCS induced spinal plasticity and increased spinal excitability. This TSCS protocol also increased muscle activation in response to specific pelvic force perturbations. These results suggest that TSCS can modulate the integration of voluntary descending commands and sensory signals and alter muscle activation during a postural task, even in neurologically intact subjects. We plan to use these results to develop training protocols to improve balance during standing in patients with spinal cord injury (SCI).
High-performance scintillator screen for medical imaging applications (2004)

We report on recent advances in the development of powdered Lu<sub>2</sub>O<sub>3</sub>:Eu scintillator screens. The Lu<sub>2</sub>O<sub>3</sub>:Eu scintillator has excellent intrinsic material properties including high density (9.5 g/cm<sup>3</sup>), high average atomic number (63), and a peak emission of 610 nm. We have characterized the performance of screens fabricated from this material in comparison with commercial Gd<sub>2</sub>O<sub>2</sub>S:Tb screens. This paper presents resolution in terms of MTF(<i>f</i>), noise properties in terms of NPS(<i>f</i>), and overall NEQ(<i>f</i>), obtained by coupling the screens to a CCD detector. We have included sample radiographic images that demonstrate the ability to produce high quality images. These screens are currently under development, and further improvements in performance are expected with optimization of the scintillator and fabrication methods.
ChemInform Abstract: Functionalization of Saturated Hydrocarbons. Part 7. On the Mechanism of the Degradation of the Cholesterol Side‐Chain to 20‐Ketone by Oxidation with the Gif System. (1987)

Abstract The 3α‐acetoxy steroids (Ia) and (Ib) ‐ both obtained in several steps from lithocholic acid acetate (Ic) ‐ are converted to the ketones (II), which undergo double dehydrogenation to give the dienones (III).
Static conductivity and superconductivity of carbon nanotubes: Relations between tubes and sheets (1995)

We relate the static conductivity of carbon nanotubes to the static in-plane conductivity of a graphite sheet and conclude that isolated single-wall nanotubes are excellent conductors. In contrast, multiwall tubes at low doping may possess conductivities substantially below that of the sum of the constituent tubes. The curvature of small tubes opens new electron-phonon scattering channels that are not available to sheets. This increases the electron-phonon coupling and yields superconducting transition temperatures for small doped tubes intermediate between those of intercalated graphite and alkali-metal-doped ${\mathrm{C}}_{60}$.
Simple optimization procedure for objective lens correction collar setting (2005)

We present a new method for setting a coverglass correction collar on an objective lens. Axial scans across the interface between the specimen volume and the slide are used together with a quantitative function of merit to determine the optimum setting of the correction collar. The method, which simplifies the adjustment for the user and reduces photobleaching, was implemented within the software environment of a scanning microscope system.
Is lidocaine Bier's block safe? (2012)

No clinically significant morbidity or mortality as a consequence of lidocaine Bier's block was demonstrated in this audit.
Optical response of large-area aluminum-coated nano-bucket arrays on flexible PET substrates (2014)

The high-cost of fabrication of nanohole arrays for extraordinary optical transmission, surface-plasmon-resonance-based sensors, inhibits their widespread commercial adoption. Production typically involves the application of small-area patterning techniques, such as focused-ion-beam milling, and electron-beam lithography onto high-cost gold-coated substrates. Moving to lower-cost manufacturing is a critical step for applications such as the detection of environmental oil-leaks, or water quality assurance. In these applications, the sensitivity requirements are relatively low, and a bio-compatible inert surface, such as gold, is unnecessary. We report on the optical response of aluminum-coated nano-bucket arrays fabricated on flexible polyethylene terephthalate substrates. The arrays are fabricated using an economical roll-to-roll UV-casting process from large sheets of nickel templates generated from master quartz stamps. The nano-featured surface is subsequently coated with 50 nm of thermally-evaporated aluminum. The roll-to-roll production process has a 97% yield over a 600 m roll producing nano-buckets with 240 nm diameters, 300 nm deep, with a 70° taper. When exposed to a series of refractive index standards (glucose solutions), changes in the locations of the resonance transmission peaks result in optical sensitivities as high as 390 ± 20 nm/RIU. The peak transmission is approximately 5% of illumination, well within the sensitivity requirements of most common low-cost detectors.
Elucidating the Ordering in Self-Assembled Glycocalyx Mimicking Supramolecular Copolymers in Water (2019)

Polysaccharides present in the glycocalyx and extracellular matrix are highly important for a multitude of functions. Oligo- and polysaccharides-based biomaterials are being developed to mimic the glycocalyx, but the spatial functionalization of these polysaccharides represents a major challenge. In this paper, a series of benzene-1,3,5-tricarboxamide (BTA) based supramolecular monomers is designed and synthesized with mono- (BTA-β-d-glucose; BTA-Glc and BTA-α-d-mannose; BTA-Man) or disaccharides (BTA-β-d-cellobiose; BTA-Cel) at their periphery or a monosaccharide (BTA-OEG<sub>4</sub>-α-d-mannose; BTA-OEG<sub>4</sub>-Man) at the end of a tetraethylene glycol linker. These glycosylated BTAs have been used to generate supramolecular assemblies and it is shown that the nature of the carbohydrate appendage is crucial for the supramolecular (co)polymerization behavior. BTA-Glc and BTA-Man are shown to assemble into micrometers long 1D (bundled) fibers with opposite helicities, whereas BTA-Cel and BTA-OEG<sub>4</sub>-Man formed small spherical micelles. The latter two monomers are used in a copolymerization approach with BTA-Glc, BTA-Man, or ethylene glycol BTA (BTA-OEG<sub>4</sub>) to give 1D fibers with BTA-Cel or BTA-OEG<sub>4</sub>-Man incorporated. Consequently, the carbohydrate appendage influences both the assembly behavior and the internal order. Using this approach it is possible to create 1D-fibers with adjustable saccharide densities exhibiting tailored dynamic exchange profiles. Furthermore, hydrogels with tunable mechanical properties can be achieved, opening up possibilities for the development of multicomponent functional biomaterials.
Identification and Quantification of MIDD0301 Metabolites (2021)

MIDD0301 undergoes no phase I and moderate phase II metabolism.
Bifunctional HPPH-N2S2-99mTc conjugates as tumor imaging agents: synthesis and biodistribution studies (2003)

Pyropheophorbide-a and the corresponding 3-(1'-hexyloxyethyl)-3-devinyl derivative ( HPPH ), the tumor-avid photosensitizers were conjugated with mono- or di-bisaminoethanethiols ( N 2 S 2 ligand). The in vivo biodistribution study of the related 99m Tc complexes was performed in F-344 rats bearing Ward colon tumors at 4 h and 24 h post injection. These data show that the complexes are stable and among four tracers, HPPH di- 99 m Tc N 2 S 2 conjugate reaches the highest tumor uptake (%ID/g). The larger tumors reach higher concentrations of the tracer. However, the short 6 h half life of 99 m Tc is incompatible with the 24 h imaging time, suggesting that the use of a longer-lived isotope such as 111 In could still provide a useful scanning agent, or that further structure-activity screening could yield an HPPH analog with more appropriate pharmacokinetics for tumor imaging with 99 m Tc .
Quantitative semi-automated analysis of morphogenesis with single-cell resolution in complex embryos (2012)

A quantitative understanding of tissue morphogenesis requires description of the movements of individual cells in space and over time. In transparent embryos, such as C. elegans, fluorescently labeled nuclei can be imaged in three-dimensional time-lapse (4D) movies and automatically tracked through early cleavage divisions up to ~350 nuclei. A similar analysis of later stages of C. elegans development has been challenging owing to the increased error rates of automated tracking of large numbers of densely packed nuclei. We present Nucleitracker4D, a freely available software solution for tracking nuclei in complex embryos that integrates automated tracking of nuclei in local searches with manual curation. Using these methods, we have been able to track >99% of all nuclei generated in the C. elegans embryo. Our analysis reveals that ventral enclosure of the epidermis is accompanied by complex coordinated migration of the neuronal substrate. We can efficiently track large numbers of migrating nuclei in 4D movies of zebrafish cardiac morphogenesis, suggesting that this approach is generally useful in situations in which the number, packing or dynamics of nuclei present challenges for automated tracking.
Effects of chicken essence on recovery from mental fatigue in healthy males (2013)

We showed that daily intake of essence of chicken could be effective for the recovery from mental fatigue and is a promising candidate for use as an anti-fatigue food.
Optimal design and critical analysis of a high resolution video plenoptic demonstrator (2011)

A plenoptic camera is a natural multi-view acquisition device also capable of measuring distances by correlating a set of images acquired under different parallaxes. Its single lens and single sensor architecture have two downsides: limited resolution and depth sensitivity. In a very first step and in order to circumvent those shortcomings, we have investigated how the basic design parameters of a plenoptic camera optimize both the resolution of each view and also its depth measuring capability. In a second step, we built a prototype based on a very high resolution Red One&#174; movie camera with an external plenoptic adapter and a relay lens. The prototype delivered 5 video views of 820x410. The main limitation in our prototype is view cross talk due to optical aberrations which reduce the depth accuracy performance. We have simulated some limiting optical aberrations and predicted its impact on the performances of the camera. In addition, we developed adjustment protocols based on a simple pattern and analyzing programs which investigate the view mapping and amount of parallax crosstalk on the sensor on a pixel basis. The results of these developments enabled us to adjust the lenslet array with a sub micrometer precision and to mark the pixels of the sensor where the views do not register properly.
Gigahertz-frequency operation of a LaAlO3/SrTiO3-based nanotransistor (2013)

Nanoscale control of the metal-insulator transition of the LaAlO3/SrTiO3 interface with a conductive-atomic force microscope (c-AFM) technique has enabled a variety of electrical and photonic device concepts. While previous devices have demonstrated sub-10 nm critical features, information processing applications also require high operating speeds. Here we show that a “sketched” nanoscale transistor (“SketchFET”) can operate at frequencies in excess of 2 GHz. The combination of high speed and high conductance with a small footprint make these devices and this platform attractive for sub-10 nm computing and storage architectures.
Reducing Rate of Fertility Multiples Requires Policy Changes (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Atrial Therapies Reduce Atrial Arrhythmia Burden in Defibrillator Patients (2001)

In this study, patients with a standard ICD indication and atrial tachyarrhythmias had a significant reduction in atrial tachyarrhythmia burden with use of atrial pacing and shock therapies.
1463: EFFICACY OF HIGH AND LOW DOSES OF NOVEL PSC-INDUCED MESENCHYMAL STROMAL CELLS IN OVINE ARDS (2021)

Homma, Kento; Hashimoto, Kazuki; Bazhanov, Nikolay; Angel, Matt; Lader, Alan; Czuczman, Myron; Matthay, Michael; Enkhbaatar, Perenlei Author Information
Luminescence of black silicon (2008)

Room temperature visible and near-infrared photoluminescence from black silicon has been observed. The black silicon is manufactured by shining femtosecond laser pulses on silicon wafers in air, which were later annealed in vacuum. The photoluminescence is quenched above 120 K due to thermalization and competing nonradiative recombination of the carriers. The photoluminescence intensity at 10K depends sublinearly on the excitation laser intensity confirming band tail recombination at the defect sites.
ChemInform Abstract: A Synthetic Route to 3‐(Dialkylamino)phenothiazin‐5‐ium Salts and 3,7‐ Disubstituted Derivatives Containing Two Different Amino Groups. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Peculiar Velocity Limits from Measurements of the Spectrum of the Sunyaev‐Zeldovich Effect in Six Clusters of Galaxies (2003)

We have made measurements of the Sunyaev-Zeldovich (SZ) effect in six galaxy clusters at z &gt; 0.2 using the Sunyaev-Zeldovich Infrared Experiment (SuZIE II) in three frequency bands between 150 and 350 GHz. Simultaneous multifrequency measurements have been used to distinguish between thermal and kinematic components of the SZ effect and to significantly reduce the effects of variations in atmospheric emission that can otherwise dominate the noise. We have set limits to the peculiar velocities of each cluster with respect to the Hubble flow and have used the cluster sample to set a 95% confidence limit of less than 1420 km s-1 to the bulk flow of the intermediate-redshift universe in the direction of the cosmic microwave background dipole. This is the first time that SZ measurements have been used to constrain bulk flows. We show that systematic uncertainties in peculiar velocity determinations from the SZ effect are likely to be dominated by submillimeter point sources, and we discuss the level of this contamination.