gebhart/patrepeval huggingface dataset:
The Effect of Medial Versus Lateral Meniscectomy on the Stability of the Anterior Cruciate Ligament-Deficient Knee (2010)

This model may have implications in the evaluation of surgical reconstruction procedures in complex knee injuries.
Abstract 13079: Synergistic Effect of Human Cardiac Stem Cells and Bone Marrow Mesenchymal Stem Cells to Reduce Infarct Size and Restore Cardiac Function (2011)

Adam R Williams, 2011 Finalist and Presenting Author
Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer (2019)

Through the use of novel digitally scored vessel-density-related metrics, this exploratory study identifies stroma-normalised VD in the invasive margin as a candidate marker for benefit of adjuvant 5-FU-based chemotherapy in stage II/III colon cancer. The findings, indicating particular importance of vessels in the invasive margin, also suggest biological mechanisms for further exploration.
GPUs surpass computers at repetitive calculations (2007)

Major performance gains can be obtained by implementing computational intelligence algorithms on graphics processing units. However, a certain amount of skill is needed for the implementation; in some cases the performance gains can be as high as 200 times, but as low as two times or actually less than CPU operation. It is necessary to understand the limitations of the graphics processing hardware and to take these limitations into account in developing algorithms targeted at the GPU. It is important to note that all the examples in this document were operating on last-generation hardware. The next generation of graphics hardware is now available, and includes an order of magnitude more shader units per processor, as well as improved branching capabilities. Consider the possible capability of 512 programmable pipelines working in parallel at 1.5 GHz each, providing the amount of computing power previously seen in large supercomputers on a single desktop machine, at a fraction of the cost. These extremely powerful computing tools are now at the disposal of software designers for entertainment, scientific- computing, and computational intelligence applications.
Array-based detection of genetic alterations associated with disease (2023)

The present invention relates to DNA sequences from regions of copy number change on chromosome 20. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases.
Impact of mental health on health specific quality of life for patients with chronic otitis media (2018)

Patients with chronic otitis media (COM) complain about otorrhoea und hardness of hearing. Spreading over many years and frequently including mutiple operations, the course of disease restricts the quality of life of the affected patients. The impairment of mental health can therefore be the consequence. However no data is available so far.
Optimizing Bi-Objective Imperfect Preventive Maintenance Model for Multi-Component System Using a Proposed Improved PSO Algorithm (2013)

This study aims to establish a bi-objective imperfect preventive maintenance (BOIPM) model in which the total maintenance cost and the mean system reliability are optimized by determining the maintenance periods and maintenance activities simultaneously. To efficiently solve the established BOIPM model, this study proposes an improved particle swarm optimization (IPSO) algorithm. The IPSO extends the practicability of the conventional PSO originally designed to solve an optimization problem with continuous decision variables. Furthermore, time-varying mechanisms associated with search parameters of the PSO are utilized to enhance the particles search capability. An adjustment mechanism addressing the issue of particles falling into the infeasible area is constructed to enhance the exploring ability of the IPSO. A case verifies the effectiveness of the proposed approach.
MayBMS: Managing Incomplete Information with Probabilistic World-Set Decompositions (2007)

Managing incomplete information is important in many real world applications. In this demonstration we present MayBMS - a system for representing and managing finite sets of possible worlds - that successfully combines expressiveness and efficiency. Some features of MayBMS are: completeness of the representation system for finite world-sets; space-efficient representation of large world-sets; scalable evaluation and support for full relational algebra queries; and probabilistic extension of the representation system and the query language. MayBMS is implemented on top of PostgreSQL. It models incomplete data using the so-called world-set decompositions (WSDs) (Ruggles et al., 2004). For this demonstration, we introduce a probabilistic extension of world-sets and WSDs, where worlds or correlations between worlds have probabilities. The main idea underlying probabilistic WSDs is to use relational factorization combined with probabilistic independence in order to efficiently decompose large world-sets into a set of independent smaller relations. Queries in MayBMS can be expressed in an SQL-like language with special constructs that deal with incompleteness and probabilities. MayBMS rewrites and optimizes user queries into a sequence of relational queries on world-set decompositions.
Sparse generalized Laguerre-Volterra model of neural population dynamics (2009)

To understand the function of a brain region, e.g., hippocampus, it is necessary to model its input-output property. Such a model can serve as the computational basis of the development of cortical prostheses restoring the transformation of population neural activities performed by the brain region. We formulate a sparse generalized Laguerre-Volterra model (SGLVM) for the multiple-input, multiple-output (MIMO) transformation of spike trains. A SGLVM consists of a set of feedforward Laguerre-Volterra kernels, a feedback Laguerre-Volterra kernel, and a probit link function. The sparse model representation involving only significant self and cross terms is achieved through statistical model selection and cross-validation methods. The SGLVM is applied successfully to the hippocampal CA3-CA1 population dynamics.
Beating Random Assignment for Approximating Quantum 2-Local Hamiltonian Problems. (2021)

Abstract not provided.
Children's toxicology from bench to bed - Drug-induced Renal Injury (3): Drug transporters and toxic nephropathy in childhood (2009)

The kidney is susceptible to drugs and environmental substances because of its anatomical and functional reasons, one of which is the existence of drug transport systems in proximal tubular cells. Among those, Organic anion transporter family (OAT family) plays the central role in elimination of drugs from the kidney and development of nephrotoxicity. Regarding drug nephrotoxicity in children, development of the child and the kidney should also be taken into account. This review focuses on the mechanisms of toxic nephropathy in children with special attention to the OAT family.
Efficient Multiparty Computation for Comparator Networks (2007)

We propose a multiparty protocol for various computations using comparator networks such as sorting and searching. By repeating the execution of a comparator, the proposed protocol can efficiently detect outlier values, without revealing them. In our scenario, all input values to a comparator network and the intermediate output from each comparator are kept secret assuming the presence of an honest majority. Possible application areas for the proposed protocol include statistical analysis while preserving the privacy of respondents.
Class-of-service mapping for QoS (2004)

The ability to provide different Quality of Service (QoS) guarantees to traffic from different applications is a highly desired feature for many IP network operators, particularly for enterprise networks. Although various mechanisms exist for providing QoS in the network, QoS is yet to be widely deployed. We believe that a key factor holding back widespread QoS adoption is the absence of suitable methodologies/processes for appropriately mapping the traffic from different applications to different QoS classes. This is a challenging task, because many enterprise network operators who are interested in QoS do not know all the applications running on their network, and furthermore, over recent years port-based application classification has become problematic. We argue that measurement based automated Class of Service (CoS) mapping is an important practical problem that needs to be studied.
A Robustly Supported Extracellular Matrix Improves the Intravascular Delivery Efficacy of Endothelial Progenitor Cells (2021)

Abstract A major barrier in the multi‐purpose use of implantable materials is an incomplete integration with surrounding tissues, causing foreign body reactions, such as fibrous encapsulation and chronic inflammation. From its viewpoint, a universal method is suggested for cloaking any kind of substrate in specific cell‐made extracellular matrices (ECMs) via robust linkages for delivery of therapeutic cells. In addition, the feasibility of ECM‐coated substrates as endothelial progenitor cells (EPCs)‐laden coronary stent platform for endovascular implantation is investigated. Characteristics and stability of cell‐secreted ECMs anchored on a substrate are evaluated, and structural and componential features are revealed similar to those of native ECMs, with enough strength to enable practical uses. The in vitro experiments demonstrated that the ECM coating effectively supports the adhesion, proliferation, and viability of EPCs and has selectively opposite effects on smooth muscle cells. The in vivo experiments using a porcine coronary model supports that ECM‐coated stents enable endothelial regeneration and inhibit neointimal growth, and the cell‐laden form is more effective than other stents. These results will allow the preparation of tissue‐integrating materials containing cellular microenvironments and safely coat surfaces with cells to enable long‐term implantation and the continuous managing of chronic diseases.
ALGORITHM FOR POINT CLOUD OCCLUSION MAPPING ON AN AUTONOMOUS GROUND VEHICLE (2024)

&lt;title&gt;ABSTRACT&lt;/title&gt; &lt;p&gt;For safe navigation through an environment, autonomous ground vehicles rely on sensory inputs such as cameras, LiDAR, and radar for detection and classification of obstacles and impassable terrain. These sensors provide data representing 3D space surrounding the vehicle. Often this data is obscured by dust, precipitation, objects, or terrain, producing gaps in the sensor field of view. These gaps, or occlusions, can indicate the presence of obstacles, negative obstacles, or rough terrain. Because sensors receive no data in these occlusions, sensor data provides no explicit information about what might be found in the occluded areas. To provide the navigation system with a more complete model of the environment, information about the occlusions must be inferred from sensor data. In this paper we show a probabilistic method for mapping point cloud occlusions in real-time and how knowledge of these occlusions can be integrated into an autonomous vehicle obstacle detection and avoidance system.&lt;/p&gt;
Standoff raman spectroscopy system for remote chemical detection (2005)

We have developed a class of aperture coding schemes for Remote Raman Spectrometers (RRS) that remove the traditional trade-off between throughput and spectral resolution. As a result, the size of the remote interrogation region can be driven by operational, rather than optical considerations. In this paper we present the design of our coded-aperture standoff spectroscopy system as well as experimental data collected while making remote measurements.
Inert 50-nm Polystyrene Nanoparticles That Modify Pulmonary Dendritic Cell Function and Inhibit Allergic Airway Inflammation (2011)

Nanoparticles are being developed for diverse biomedical applications, but there is concern about their potential to promote inflammation, particularly in the lung. Although a variety of ambient, anthropogenic and man-made nanoparticles can promote lung inflammation, little is known about the long-term immunomodulatory effects of inert noninflammatory nanoparticles. We previously showed polystyrene 50-nm nanoparticles coated with the neutral amino acid glycine (PS50G nanoparticles) are not inflammatory and are taken up preferentially by dendritic cells (DCs) in the periphery. We tested the effects of such nanoparticles on pulmonary DC function and the development of acute allergic airway inflammation. Surprisingly, exposure to PS50G nanoparticles did not exacerbate but instead inhibited key features of allergic airway inflammation including lung airway and parenchymal inflammation, airway epithelial mucus production, and serum allergen-specific IgE and allergen-specific Th2 cytokines in the lung-draining lymph node (LN) after allergen challenge 1 mo later. PS50G nanoparticles themselves did not induce lung oxidative stress or cardiac or lung inflammation. Mechanistically, PS50G nanoparticles did not impair peripheral allergen sensitization but exerted their effect at the lung allergen challenge phase by inhibiting expansion of CD11c(+)MHCII(hi) DCs in the lung and draining LN and allergen-laden CD11b(hi)MHCII(hi) DCs in the lung after allergen challenge. PS50G nanoparticles further suppressed the ability of CD11b(hi) DCs in the draining LN of allergen-challenged mice to induce proliferation of OVA-specific CD4(+) T cells. The discovery that a defined type of nanoparticle can inhibit, rather than promote, lung inflammation via modulation of DC function opens the door to the discovery of other nanoparticle types with exciting beneficial properties.
Multispectral plasmonic crystal sensors (2023)

The present invention provides plasmonic crystals comprising three-dimensional and quasi comprising three-dimensional distributions of metallic or semiconducting films, including multi-layered crystal structures comprising nanostructured films and film arrays. Plasmonic crystals of the present invention include precisely registered and deterministically selected nonplanar crystal geometries and spatial distributions providing highly coupled, localized plasmonic responses in thin film elements and/or nanostructures of the crystal. Coupling of plasmonic responses provided by three-dimensional and quasi-three dimensional plasmonic crystal geometries and structures of the present invention generates enhanced local plasmonic field distributions useful for detecting small changes in the composition of an external dielectric environment proximate to a sensing surface of the plasmonic crystal. Plasmonic crystal structures of the present invention are also useful for providing highly localized excitation and/or imaging of fluorophores proximate to the crystal surface.
Adolescents with Hodgkin lymphoma: old children or young adults? (2011)

Hodgkin lymphoma (HL) is a malignancy of the lymphatic system with an incidence of 2-3/100,000/year in Europe and North America. The disease generally occurs in all age groups, but young adults are most often affected. Thus, adolescents aged 15 or 16 to 21 represent a relevant portion of patients. The optimum treatment for this age group is undefined. Both pediatric protocols such as OEPA (vincristine, etoposide, prednisone, adriamycin) or ABVE-PC (adriamycin, bleomycin, vincristine, etoposide, prednisone, cyclophosphamide) and adult regimens such as ABVD (adriamycin, bleomycin, vinblastine, dacarbazine) or BEACOPP (bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine, prednisone) have been shown to be safe and active, resulting in long-term survival rates of 80% and more. However, a prospective comparison of pediatric and adult treatment strategies in terms of efficacy and other important questions such as treatment-related acute and long-term toxicity has not been undertaken so far. This review aims at shedding some light on potential treatment approaches for adolescents with HL and includes more recent analyses in this patient group.
Commercialization of Fuel Cell Bipolar Plate Manufacturing by Electromagnetic Forming (2010)

The cost of manufacturing bipolar plates is a major component to the overall cost structure of a Proton Exchange Membrane (PEM) fuel cell stack. To achieve the commercialization of PEM fuel cells, a high volume and low cost manufacturing process for the bipolar plate must be developed. American Trim has identified high velocity electromagnetic forming as a suitable technology to manufacture metallic fuel cell bipolar plates, because of its low capital cost, flexible tooling and rapid prototyping capability. Through the support from the State of Ohio Third Frontier Fuel Cell Program, a group of collaborators consisting of American Trim, The Ohio State University and General Motors have developed a commercially viable prototype production process to manufacture metallic fuel cell bipolar plates in which electromagnetic coils and forming dies were integrated. To manufacture fuel cell bipolar plates, a metal sheet is accelerated by electromagnetic force to impact against, and take the shape of, the forming die surface. A novel approach which introduces a compliant layer eliminates the need for expendable driver plates in order to reduce the production cost. This process enables continuous manufacturing of fuel cell bipolar plates in short-time cycles at very low cost, which demonstrates strong potential for commercialization. This paper will introduce the electromagnetic forming process developed to manufacture metallic bipolar plates, and include a discussion of the preliminary results. The benefits of using this high velocity electromagnetic forming process over a traditional stamping press will also be discussed. To commercialize electromagnetic forming, coil life and die wear are being investigated. The results of some preliminary experiments involving coil durability and die wear will also be presented.
Continuous-time optimization of gate timing for synchronous rectification (2002)

Synchronous rectifiers, which use a controlled MOSFET in place of a standard p-n or Schottky rectifier, are an important technology for low-voltage power converters. Conventional control techniques for synchronous rectification are often very conservative, however, leaving room for improvement. This paper presents a method for monitoring current flow to adaptively optimize the relative timing of two gate signals for a buck converter with synchronous rectification. Theoretical development is given, along with experimental results for two low-voltage converters.
375 Evaluation of extruded soybean hulls for relative metabolizable energy values and as a source of fiber in monogastric nutrition. (2018)

The aims of this experiment were to determine the energy value of raw soybean hulls, in comparison to the energy values of soybean hulls post-extrusion. The roosters were precision-fed up 25 g of either raw or extruded soy hulls, then placed into individual cages with a collection tray underneath to catch excreta. After 48 h, the excreta was collected and analyzed for N, gross energy, dry matter and organic matter. The results of the rooster assay did not differ (P > 0.05) between the raw and extruded soybeans. However, the TMEn (kcal/g) were numerically smaller for the conventional roosters compared to the cecectomized. This indicates that there was very little fermentation of the soybean hulls in the ceca of the roosters. In addition to the rooster assay, a chick growth assay was conducted using Ross 308 male broiler chicks. The study lasted 14 d. Seven-day old chicks (BW: 87.0 ± SEM g). The experimental diets consisted of 7.5% and 15% inclusion of both raw and extruded soybean hulls, respectfully, added at the expense of cellulose. The chicks’ BW, feed intake, and G:F ratio were all calculated throughout the study. The results of the chick assay were more striking than that of the rooster assay. Chicks fed the 15% extruded soybean hulls diet had similar performance (P > 0.05) to the positive control; a traditional soybean meal and corn diet. In conclusion, the chick growth assay, used in combination with the precision-fed rooster assay, were able to detect differences between raw and extruded soybean hulls. These data may allow different monogastric animal production systems to include soybean hulls into diet formulation. Whether it be inclusion into weight control diets, low-energy molting diets, or for low-energy, low-cost fiber products.
CLINICAL CHARACTERISTICS OF ESSENTIAL HYPETENSION WITH HYPOADIPONECTINEIMA RELATED WITH INCREASED PLASMA ALDOSTERONE CONCENTRATION (2004)

Ohishi, M; Ito, N; Kaibe, M; Takagi, T; Ouchi, N; Kihara, S; Funahashi, T; Katsuya, T; Rakugi, H; Ogihara, T Author Information
Supplementary Figure 6 from DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy <i>In Vivo</i> (2023)

&lt;p&gt;PDF file - 740K, Neither anti-EphrinB2 nor sEphB4 affected the growth of U87-EV tumors in vivo. Compared to the control, neutralizing anti-EphrinB2 antibody (B2) alone (blue arrowhead) did not affect the tumor growth. Also, combined anti-EphrinB2 antibody (blue arrowhead) with bevacizumab (purple arrowhead) did not increase the therapeutic efficacy of bevacizumab. Similar results were obtained for sEphB4. Mean � SE, N=5. **P&lt;0.01.&lt;/p&gt;
Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma (2023)

A select group of patients with hepatocellular carcinomas (HCC) benefit from surgical, radiologic, and systemic therapies that include a combination of anti-angiogenic and immune-checkpoint inhibitors. However, because HCC is generally asymptomatic in its early stages, this not only leads to late diagnosis, but also to therapy resistance. The nucleoside analogue 6-thio-dG (THIO) is a first-in-class telomerase-mediated telomere-targeting anticancer agent. In telomerase expressing cancer cells, THIO is converted into the corresponding 5'-triphosphate, which is efficiently incorporated into telomeres by telomerase, activating telomere damage responses and apoptotic pathways. Here, we show how THIO is effective in controlling tumor growth and, when combined with immune checkpoint inhibitors, is even more effective in a T-cell-dependent manner. We also show telomere stress induced by THIO increases both innate sensing and adaptive antitumor immunity in HCC. Importantly, the extracellular high-mobility group box 1 protein acts as a prototypical endogenous DAMP (Damage Associated Molecular Pattern) in eliciting adaptive immunity by THIO. These results provide a strong rationale for combining telomere-targeted therapy with immunotherapy.
Discovery of Novel Irreversible Inhibitors of Interleukin (IL)-2-inducible Tyrosine Kinase (Itk) by Targeting Cysteine 442 in the ATP Pocket (2013)

IL-2-inducible tyrosine kinase (Itk) plays a key role in antigen receptor signaling in T cells and is considered an important target for anti-inflammatory drug discovery. In order to generate inhibitors with the necessary potency and selectivity, a compound that targeted cysteine 442 in the ATP binding pocket and with an envisaged irreversible mode of action was designed. We incorporated a high degree of molecular recognition and specific design features making the compound suitable for inhaled delivery. This study confirms the irreversible covalent binding of the inhibitor to the kinase by x-ray crystallography and enzymology while demonstrating potency, selectivity, and prolonged duration of action in in vitro biological assays. The biosynthetic turnover of the kinase was also examined as a critical factor when designing irreversible inhibitors for extended duration of action. The exemplified Itk inhibitor demonstrated inhibition of both TH1 and TH2 cytokines, was additive with fluticasone propionate, and inhibited cytokine release from human lung fragments. Finally, we describe an in vivo pharmacodynamic assay that allows rapid preclinical development without animal efficacy models.