gebhart/patrepeval huggingface dataset:
Photoacoustic microscopy of blood pulse wave (2012)

Blood pulse wave velocity (PWV) is an important physiological parameter that characterizes vascular stiffness. In this letter, we present electrocardiogram-synchronized, photoacoustic microscopy for noninvasive quantification of the PWV in the peripheral vessels of living mice. Interestingly, blood pulse wave-induced fluctuations in blood flow speed were clearly observed in arteries and arterioles, but not in veins or venules. Simultaneously recorded electrocardiograms served as references to measure the travel time of the pulse wave between two cross sections of a chosen vessel and vessel segmentation analysis enabled accurate quantification of the travel distance. PWVs were quantified in ten vessel segments from two mice. Statistical analysis shows a linear correlation between the PWV and the vessel diameter which agrees with known physiology.
Multiple metal-carbon bonds. 25. Preparation and structure of tungsten neopentylidene hydride, neopentylidene carbonyl, and neopentylidene ethylene complexes (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple metal-carbon bonds. 25. Preparation and structure of tungsten neopentylidene hydride, neopentylidene carbonyl, and neopentylidene ethylene complexesJ. H. Wengrovius, R. R. Schrock, M. R. Churchill, and H. J. WassermanCite this: J. Am. Chem. Soc. 1982, 104, 6, 1739–1740Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://pubs.acs.org/doi/10.1021/ja00370a051https://doi.org/10.1021/ja00370a051research-articleACS PublicationsRequest reuse permissionsArticle Views239Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Investigations of NucleosideH-Phosphonamidate in the Design of Nucleotide Prodrug (2003)

The synthesis, anti-HIV activity and stability studies of a H-phosphonamidate derivative of 3'-azido-2',3'-dideoxythymidine (AZT) incorporating a N,N-diisopropylamino residue as first model of alkylamino group are reported. The results demonstrate that such phosphorylated structure exerts its biological effects via chemical hydrolysis into the corresponding H-phosphonate, precursor of the parent nucleoside.
The structure of zinc and copper oxide species hosted in porous siliceous matrices (2003)

Microporous and mesoporous siliceous phases (MFI, FAU, MCM-48, MCM-41, and SBA-15) were modified with zinc via aqueous and organometallic routes and characterized with techniques that reflect the structure of the matrix, the distribution of zinc over the matrix, and the structure of the zinc oxide species (XRD, nitrogen physisorption, IR spectroscopy, XPS, X-ray absorption fine structure (XAFS), UV-Vis spectroscopy). For comparison, MFI and MCM-48 were modified with copper alone and characterised by XPS/X-ray induced Auger electron spectroscopy and XAFS. From the results, it can be concluded that zinc interacts strongly with the siliceous surfaces, which prevents the formation of ZnO aggregates even when the coverage exceeds the monolayer limit. While zinc could be well distributed over FAU and mesoporous matrices by treatment with diethyl zinc, it remained on the external surface of MFI, possibly due to pore entrance narrowing by adsorbed species. For MCM-48 and MCM-41, the formation of a thin, probably monolayer surface zinc silicate coating was concluded from the data. With an aqueous impregnation technique, strong changes in the pore system of MCM-48 were noted, which indicate rupture of pore walls and partial structural damage. Different from zinc, copper forms small oxide aggregates upon introduction into micro and mesoporous siliceous matrices.
3300V Scaled IGBTs Driven by 5V Gate Voltage (2019)

In this work, 5V gate drive 3300V IGBTs, designed based on a scaling principle, have been demonstrated. Turn-off characteristics without noticeable degradation in the gate voltage waveforms were confirmed. Turn-off tail current of the scaled devices significantly decreased than conventional 15V-driven devices. As a result of both Vce and turn-off loss reduction, 35% improvement in Eoff vs Vcesat relationship was achieved.
Disparate Affinities of Antifolates for Folylpolyglutamate Synthetase From Human Leukemia Cells (1997)

Previous work showed that acute myelocytic leukemia blasts accumulate less long chain polyglutamates of methotrexate (MTX) than acute lymphocytic leukemia blasts when incubated with this radiolabeled antifolate. This difference likely explains the increased sensitivity of lymphoid leukemias to short-term exposure of MTX as compared with myeloid leukemias. In this study, we examined the basis for differences between long chain MTX polyglutamate accumulation between different leukemia cell types using both leukemia cell lines and blasts freshly isolated from blood of leukemic patients. The major difference found between leukemia cells that accumulate long chain polyglutamates and those that do not were differences in Km values for the enzyme folylpolyglutamate synthetase. Km values did not change with partial purification of this enzyme, indicating that interfering substances in crude lysates were not responsible for this difference. We postulate that there may be differences in the properties of this enzyme related to tissue specific expression. In contrast to MTX, both Tomudex (Zeneca Pharmaceuticals, Wilmington, DE) and 1843U89, potent inhibitors of thymidylate synthetase, have low Kms for folylpolyglutamate synthetase, and polyglutamate forms of these inhibitors are accumulated to the same degree in both myeloid and lymphoid acute leukemia cells, paralleling the equivalent cytotoxicity found between myeloid and lymphoid leukemia cell lines. Based on these results, we believe a clinical trial of Tomudex in patients with acute myeloid leukemia is warranted.
Multicomponent access to novel proline/cyclized cysteine tethered monastrol conjugates as potential anticancer agents (2019)

The versatility of multicomponent Biginelli’s reaction is exploited in the development of proline and cyclized cysteine tethered conjugates of monastrol, a kinesin Eg5 inhibitor. Ten new conjugates are synthesized focusing on structural replacement of the ester moiety (C-5 position) of the monastrol backbone with amino acid based amide moieties. On cytotoxic evaluation, conjugate 24 has shown promising in vitro cytotoxic activity against leukemia. Molecular docking studies revealed that the conjugates 19 and 24 exhibit better interaction at kinesin Eg5 receptor compared to monastrol. Moreover, computational calculations and predictions of important molecular properties suggest that these new amino acid based conjugates could be further improved to provide potential anticancer agents.
De Novo Damaging Variants, Clinical Phenotypes, and Post-Operative Outcomes in Congenital Heart Disease (2020)

In patients with congenital heart disease undergoing open-heart surgery, de novo variants were associated with worse transplant-free survival and longer times on the ventilator. De novo variants were most strongly associated with adverse outcomes among patients without extra-cardiac anomalies, suggesting a benefit for preoperative genetic testing even when genetic abnormalities are not suspected during routine clinical practice. Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01196182.
Thermal Monitoring Technique for Limiting Energy Accumulation in Automotive Power Switches within SOA (2019)

In this work, a relative thermal shutdown circuit is implemented to monitor abrupt junction temperature rise and provide reliable solution to keep device operation within its SOA limit for high in-rush current applications like light-bulb driving in an automotive system by effectively limiting energy accumulation, which turns into heat and causes thermal runaway in power switch devices. Relative thermal shutdown in a MCM (multi-chip-module) package solution is implemented by independently sensing and comparing the thermal diode voltages on both controller die and power-MOSFET die, and when the temperature of the power-MOSFET exceeds the temperature of controller by a certain threshold, the relative thermal shutdown is triggered to shut down and protect the device. Depending on the relative thermal shutdown threshold level, the total energy accumulation in the 8mohm high side switch during short-circuit test with 85A output current clamping is effectively limited under 80mJ (with 30° C threshold) to 145mJ (with 65° C threshold). Silicon validation results show that 8mΩ automotive high-side switch with the relative thermal shutdown protection circuit can pass >160k cycles of 300ms enable pulses to short circuit loading condition (AECQ100-12) with 85A current limit.
Preliminary analysis of feasible benchmark problems for the hydrid PRAM/NUMA REPLICA architecture (2012)

We study benchmarking on modern chip multi-processors (CMP), and outline a set of programs to measure the architectural performance properties, focusing on the REPLICA architecture employing a hybrid of PRAM and NUMA computational models. We analyse the parallel data processing and storage mechanisms on mainstream and research CMPs and their utilization in benchmarks to identify the strong and weak points of REPLICA and to further develop the benchmarks to demonstrate its scalability and performance.
An analysis of factors affecting the incidence of inhibitor formation in patients with congenital haemophilia in Japan (2011)

Studies conducted in European and North American countries have demonstrated that various factors including races affect the frequency of inhibitor formation in haemophilia patients. The present study was undertaken to analyse factors affecting the incidence of inhibitor formation in Japanese haemophilia A and B patients. Analytical data were retrospectively collected from haemophilia A and B patients born after 1988, the year when monoclonal antibody-purified factor VIII products were first marketed in Japan. Various data were collected from 184 patients (153 cases of haemophilia A; 31 cases of haemophilia B). The sample size of haemophilia B cases was too small to reveal any significant differences between the inhibitor formation group and the inhibitor-free group in any of background variables. For patients with haemophilia A, on the other hand, univariate analysis identified the severity of haemophilia and a positive family history of inhibitor development as risk factors for the formation of inhibitors. In analyses of the clotting factor products used, the incidence of inhibitor formation did not differ significantly between the group treated with plasma-derived products (29.7%) and the group treated with recombinant products (25.0%). When background variables were compared, age was higher in the group treated with plasma-derived products but none of the other background variables differed between the two groups. These results suggest that in Japanese haemophilia patients, the type of clotting factor preparations used for therapy has not influenced the incidence of inhibitor formation.
A Phase 3, Placebo Controlled Study of the Safety and Efficacy of Avanafil for the Treatment of Erectile Dysfunction After Nerve Sparing Radical Prostatectomy (2012)

Avanafil in 100 and 200 mg doses was effective and well tolerated in improving erectile function after prostatectomy. Results suggest a rapid onset of action and sustained duration of effect, with all 3 primary end points being achieved at both dose levels.
Endocrine Actions of Bile Acids Via Nuclear Receptors and FGFs (2007)

Bile acids are amphipathic cholesterol metabolites that are required for the solubilization of lipophilic nutrients in the small intestine and also influence whole‐body lipid homeostasis. Many of the biological actions of bile acids are mediated through the nuclear receptor FXR, which is highly expressed in liver and intestine. Evidence will be presented that activation of FXR in small intestine induces expression of the hormone fibroblast growth factor 15 (FGF15), which in turn regulates bile acid homeostasis in multiple tissues. Administration of FGF15 to mice rapidly represses bile acid synthesis in liver and induces gallbladder filling. We will present our most recent findings regarding the functions of FXR and FGF15 in the regulation of digestion and lipid homeostasis.
Plasma enhanced atomic layer etching of high-k layers on WS2 (2022)

The etching of HfO2 and ZrO2 high-k dielectrics is studied using plasma enhanced atomic layer etching. The etching method relies on a continuous argon inductively coupled plasma discharge in which reactive gases are pulsed, followed by substrate biasing; both steps are separated by purge periods. It is found that pure BCl3 is too chemically active while a Cl2–BCl3 allows a high process synergy; in addition, the latter gives a high selectivity to SiO2. The optimal etch conditions are applied to high-k layers deposited on top of WS2 transition metal dichalcogenide. Postetch analysis shows negligible tungsten and sulfur depletion as well as negligible change in optical (Raman) response of the 2D layer, indicating that atomic layer etching concepts allows us to prevent WS2 material loss or damage.
Passive seismic imaging of hydraulic fracture proppant placement (2004)

Passive seismic imaging of hydraulic fracturing can be used to map the fracture geometry and development, determine fracture complexity and calibrate numerical fracture simulations. This is predominantly based on hypocentral location, the most fundamental parameter that can be determined from the discrete acoustic emissions or microearthquakes recorded during the fracturing treatment. Other aspects of the seismic deformation can also be inferred from the signal characteristics, including attributes that define the seismic source strength, size and strain. Using all of the seismic data to image the fracture development, and by integrating pump data and fracture modeling, the overall fracture effectiveness can also be assessed. Here we present a case study investigating proppant placement during a hydraulic fracture.
Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor (2016)

Fungal genome projects are revealing thousands of cryptic secondary metabolism (SM) biosynthetic gene clusters that encode pathways that potentially produce valuable compounds. Heterologous expression systems should allow these clusters to be expressed and their products obtained, but approaches are needed to identify the most valuable target clusters. The inp cluster of Aspergillus nidulans contains a gene, inpE, that encodes a proteasome subunit, leading us to hypothesize that the inp cluster produces a proteasome inhibitor and inpE confers resistance to this compound. Previous efforts to express this cluster have failed, but by sequentially replacing the promoters of the genes of the cluster with a regulatable promotor, we have expressed them successfully. Expression reveals that the product of the inp cluster is the proteasome inhibitor fellutamide B, and our data allow us to propose a biosynthetic pathway for the compound. By deleting inpE and activating expression of the inp cluster, we demonstrate that inpE is required for resistance to internally produced fellutamide B. These data provide experimental validation for the hypothesis that some fungal SM clusters contain genes that encode resistant forms of the enzymes targeted by the compound produced by the cluster.
The Web as a graph (2000)

The pages and hyperlinks of the World-Wide Web may be viewed as nodes and edges in a directed graph. This graph has about a billion nodes today, several billion links, and appears to grow exponentially with time. There are many reasons—mathematical, sociological, and commercial—for studying the evolution of this graph. We first review a set of algorithms that operate on the Web graph, addressing problems from Web search, automatic community discovery, and classification. We then recall a number of measurements and properties of the Web graph. Noting that traditional random graph models do not explain these observations, we propose a new family of random graph models.
Founsure 1.0: An Erasure Code Library with Efficient Repair and Update\n Features (2017)

Founsure is an open-source software library that implements a\nmulti-dimensional graph-based erasure coding entirely based on fast exclusive\nOR (XOR) logic. Its implementation utilizes compiler optimizations and\nmulti-threading to generate the right assembly code for the given multi-core\nCPU architecture with vector processing capabilities. Founsure possesses\nimportant features that shall find various applications in modern data storage,\ncommunication, and networked computer systems, in which the data needs\nprotection against device, hardware, and node failures. As data size reached\nunprecedented levels, these systems have become hungry for network bandwidth,\ncomputational resources, and average consumed power. To address that, the\nproposed library provides a three-dimensional design space that trades off the\ncomputational complexity, coding overhead, and data/node repair bandwidth to\nmeet different requirements of modern distributed data storage and processing\nsystems. Founsure library enables efficient encoding, decoding,\nrepairs/rebuilds, and updates while all the required data storage and\ncomputations are distributed across the network nodes.\n
A comparative study of surface binding of human low density and high density lipoproteins to human fibroblasts: regulation by sterols and susceptibility to proteolytic digestion (1977)

Binding of 125I-low density lipoprotein (LDL) and 125I-high density lipoprotein (HDL) was determined in cultured human fibroblasts from a normal subject and two subjects with homozygous familial hypercholesterolemia (HFH). Binding was assayed at 0 degree C to minimize the internalization of labeled lipoproteins. The binding of LDL and of HDL were compared following interventions reported to affect LDL binding in normal fibroblast. LDL binding to normal cells increased two to three fold 24 hours after transfer from medium containing whole fetal calf serum to medium containing lipoprotein-deficient fetal calf serum. This increase was completely blocked in the presence of cycloheximide (200 microgram/ml) or 7-ketocholesterol (2.5 microgram/ml). This increased capacity of normal fibroblasts to bind LDL could be reduced 70-80% by a subsequent 18-hour incubation with cholesterol (50 microgram/ml) or 7-ketocholesterol (2.5 microgram/ml). In contrast, no significant change in HDL binding to normal fibroblasts was observed after any of these interventions. HFH cells to show any significant change in either LDL binding or HDL binding following these interventions. These results suggest that HDL binding sites on normal fibroblasts are for the most part distinct from LDL binding sites. They also support the conclusion that LDL binding sites on HFH cells are for the most part qualitatively different from those on normal cells.
A supervision system for the intuitive usage of a telemanipulated surgical robotic setup (2011)

This paper introduces the OP:Sense system that is able to track objects and humans and. To reach this goal a complete surgical robotic system is built up that can be used for telemanipulation as well as for autonomous tasks, e.g. cutting or needle-insertion. Two KUKA lightweight robots that feature seven DOF and allow variable stiffness and damping due to an integrated impedance controller are used as actuators. The system includes two haptic input devices for providing haptic feedback in telemanipulation mode as well as including virtual fixtures to guide the surgeon even during telemanipulation mode. The supervision system consists of a marker-based optical tracking system, Photonic Mixer Device cameras (PMD) and rgb-d cameras (Microsoft Kinect). A simulation environment is constantly updated with the model of the environment, the model of the robots and tracked objects, the occupied space as well as tracked models of humans.
Parathyroid Hormone-Related Protein and Hypercalcemia in Patients With Metastatic Melanoma (2003)

Hypercalcemia associated with malignancy has been attributed to osteolytic processes secondary to bony metastases and to humoral factors causing increased bone resorption and decreased renal excretion of calcium. Parathyroid hormone-related protein (PTH-rP) is a humoral factor that has been associated with hypercalcemia in renal cell carcinoma, squamous cell carcinoma, and bladder carcinoma. Hypercalcemia does occur in patients with melanoma; however, few studies have reported on hypercalcemia in these patients, and even fewer have described a direct connection to PTH-rP. We here report a patient with stage IV malignant melanoma presenting with severe hypercalcemia associated with elevated PTH-rP levels. Immunohistochemistry showed strong expression of PTH-rP in biopsy of the patient's subcutaneous masses. In addition, we found a 4.9% incidence of hypercalcemia in 1,146 consecutive patients treated for metastatic melanoma at the Surgery Branch of the National Cancer Institute between January 1, 1988 and March 31, 2000. Thus, PTH-rP may play a significant role in severe hypercalcemia in patients with metastatic melanoma. The discovery of PTH-rP and relevant literature will also be reviewed.
Dynamic Nuclear Polarization of Oxygen-17 (2012)

Oxygen-17-detected DNP NMR of a water/glycerol glass enabled an 80-fold enhancement of signal intensity at 82 K, using the biradical TOTAPOL. The >6000-fold savings in acquisition time enable [superscript 17]O–[superscript 1]H distance measurements and heteronuclear correlation experiments. These experiments are the initial demonstration of the feasibility of DNP NMR on quadrupolar [superscript 17]O.
Caching using software-defined networking in LTE networks (2014)

Data consumption is increasing rapidly in mobile networks. The cost of the network infrastructure is increasing, which leads to an "end of profit" within next few years. Thus, mobile operators require a new technology that allows increasing the network capacity within low network costs. Therefore, using caching is the most evident solution to be used in their backhaul networks. However, the current architecture of LTE network does not provide sufficient flexibility to place the caches in the most optimal locations. The current work on Software-Defined Networking in Evolved Packet Core virtualization has enabled us to integrate dynamically the caching functionality in a LTE network and improve the caching system performances. In this paper, we will present the solution we designed for this aim based on Software Defined Networking technology. Moreover, we developed a testbed for the proof-of-concept and we will present the results and analyze the performances of this solution.