gebhart/patrepeval huggingface dataset:
Real-Time Video Streaming Based on TFRC Using Communication Logging for 5G HetNet (2019)

The fifth-generation (5G) mobile communication system is being researched and developed for launch as a commercial service in 2020. The 5G mobile network will include many radio access technologies, such as LTE, 5G NR, and WLAN. Therefore, a user equipment (UE) will be connected to different types of base stations as it moves within a 5G heterogeneous network. Accordingly, it is assumed that the throughput will change with each change in the serving cell. The 5G mobile network is expected to serve large capacity contents, such as 4K videos. However, a conventional video streaming method cannot effectively use the available bandwidth in a 5G heterogeneous network. In this study, we propose a sending rate adaptation method based on predictions for the available bandwidth. In the proposed method, the available bandwidth is predicted from the communication log data. The communication logging database, including past throughput with its location, is created by a UE. A UE refers to the communication log data for predictions when the serving cell is likely to change. We develop a video streaming device that implements the proposed method and evaluates its performance. The results show that the proposed method can change the sending rate and resolution according to the available bandwidth. The proposed method increases the probability of transmitting high-resolution video, which is not possible with conventional methods. Moreover, we performed subjective evaluation of the transmitted video by the proof-of-concept test. The result of the subjective evaluation shows that the proposed method improves the quality of experience for video streaming.
MUTARCH: Architectural diversity for FPGA device and IP security (2017)

Field Programmable Gate Arrays (FPGAs) are being increasingly deployed in diverse applications including the emerging Internet of Things (IoT), biomedical, and automotive systems. However, security of the FPGA configuration file (i.e. bitstream), especially during in-field reconfiguration, as well as effective safeguards against unauthorized tampering and piracy during operation, are notably lacking. The current practice of bitstreram encryption is only available in high-end FPGAs, incurs unacceptably high overhead for area/energy-constrained devices, and is susceptible to side channel attacks. In this paper, we present a fundamentally different and novel approach to FPGA security that can protect against all major attacks on FPGA, namely, unauthorized in-field reprogramming, piracy of FPGA intellectual property (IP) blocks, and targeted malicious modification of the bitstream. Our approach employs the security through diversity principle to FPGA, which is often used in the software domain. We make each device architecturally different from the others using both physical (static) and logical (time-varying) configuration keys, ensuring that attackers cannot use a priori knowledge about one device to mount an attack on another. It therefore mitigates the economic motivation for attackers to reverse engineering the bitstream and IP. The approach is compatible with modern remote upgrade techniques, and requires only small modifications to existing FPGA tool flows, making it an attractive addition to the FPGA security suite. Our experimental results show that the proposed approach achieves provably high security against tampering and piracy with worst-case 14% latency overhead and 13% area overhead.
Generation of functional I-Ed variants from an antigen-presenting macrophage cell line. (1985)

We report the ability of the BAC1.2 macrophage cell line to present antigen both to populations of antigen-primed lymph node cells and to T cell hybridomas. We also describe the selection of I-Ed variants derived from this cell line. These variants have lost the ability to present antigen to an I-Ed plus ovalbumin-specific T cell line, but retain the ability to stimulate an I-Ad plus ovalbumin-restricted T cell line, and a T cell line reactive with I-Ed alone. These variants should aid in the elucidation of structural elements of the I-E molecule involved in the interaction with helper T cells.
Prosaposin activates the androgen receptor and potentiates resistance to endocrine treatment in breast cancer (2015)

The HOXC11 target gene, PSAP, is an AR activator which facilitates adaptation to a more invasive phenotype in vitro. These findings have particular relevance to the development of resistance to AI therapy which is an emerging clinical issue. PSAP is a secreted biomarker which has potential in identifying patients failing to exhibit sustained response to hormonal treatment.
Integrated auxiliary interferometer to correct non-linear tuning errors in OFDR (2020)

Swept Wavelength Interferometry (SWI) based on Tunable Laser Source (TLS) has various applications in optical measurement and imaging. Nonlinear tuning of the TLS is always a problem in SWI and require proper correction to enhance the spatial resolution and SNR of the signal. Typically, nonlinear tuning correction requires an extra (auxiliary) interferometer. A new type of Optical Frequency Domain Reflectometry (OFDR) arrangement was proposed in which auxiliary interferometer was integrated with the main interferometer and only a single detection channel was used instead of two. This new hardware design eliminated the need for an extra photodetector and an acquisition channel for the auxiliary interferometer. Single trace having beating signal from auxiliary and Rayleigh backscattering from the main interferometer was acquired in a single detection channel. Then the beating signal of the auxiliary interferometer was used to correct nonlinear tuning effects from Rayleigh backscattered signal of the main interferometer. The feasibility of new hardware design is demonstrated by correcting nonlinear tuning effects in a 50 meters long optical fiber and performing distributed strain and temperature sensing in the OFDR technique. Furthermore, an extension of the proposed new design is also described in this paper in which the auxiliary interferometer is replaced by a high reflection event inside the Fiber Under Test (FUT) created by femtosecond laser which makes the overall system design more compact and simpler.
Continuum Approaches for Describing Solid-Gas and Solid-Liquid Flow (1992)

Two-phase continuum models have been used to describe the multiphase flow properties of solid-gas and solid-liquid mixtures. The approach is limited in that it requires many fitting functions and parameters to be determined empirically, and it does not provide natural explanations for some of the qualitative behavior of solid-fluid flow. In this report, we explore a more recent single-phase continuum model proposed by Jenkins and Savage (1982) to describe granular flow. Jenkins and McTigue (1989) have proposed a modified model to describe the flow of dense suspensions, and, hence, many of our results can be straight-forwardly extended to this flow regime as well. The solid-fluid mixture is treated as a homogeneous, compressible fluid in which the particle fluctuations about the mean flow are described in terms of an effective temperature. The particle collisions are treated as inelastic. After an introduction in which we briefly comment on the present status of the field, we describe the details of the single-phase continuum model and analyze the microscopic and macroscopic flow conditions required for the approach to be valid. We then derive numerous qualitative predictions which can be empirically verified in small-scale experiments: The flow profiles are computed for simple boundary conditions, plane Couette flow and channel flow. Segregation effects when there are two (or more) particle sizes are considered.
ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo (2010)

ADAM8 expression is increased in the interface tissue around a loosened hip prosthesis and in the pannus and synovium of patients with rheumatoid arthritis, but its potential role in these processes is unclear. ADAM8 stimulates osteoclast (OCL) formation, but the effects of overexpression or loss of expression of ADAM8 in vivo and the mechanisms responsible for the effects of ADAM8 on osteoclastogenesis are unknown. Therefore, to determine the effects of modulating ADAM expression, we generated tartrate-resistant acid phosphatase (TRAP)-ADAM8 transgenic mice that overexpress ADAM8 in the OCL lineage and ADAM8 knockout (ADAM8 KO) mice. TRAP-ADAM8 mice developed osteopenia and had increased numbers of OCL precursors that formed hypermultinucleated OCLs with an increased bone-resorbing capacity per OCL. They also had an enhanced differentiation capacity, increased TRAF6 expression, and increased NF-κB, Erk, and Akt signaling compared with wild-type (WT) littermates. This increased bone-resorbing capacity per OCL was associated with increased levels of p-Pyk2 and p-Src activation. In contrast, ADAM8 KO mice did not display a bone phenotype in vivo, but unlike WT littermates, they did not increase RANKL production, OCL formation, or calvarial fibrosis in response to tumor necrosis factor α (TNF-α) in vivo. Since loss of ADAM8 does not inhibit basal bone remodeling but only blocks the enhanced OCL formation in response to TNF-α, these results suggest that ADAM8 may be an attractive therapeutic target for preventing bone destruction associated with inflammatory disease.
Tumor necrosis factor-induced c-myc expression in the absence of mitogenesis is associated with inhibition of adipocyte differentiation. (1993)

Tumor necrosis factor (TNF) inhibits and reverses differentiation of mouse adipogenic TA1 cells. We have found that TNF induces c-myc in a sustained manner in both preadipocytes and adipocytes; in contrast, serum induces c-myc transiently and only in preadipocytes. This TNF-mediated c-myc induction is not coupled with cell proliferation but is correlated with TNF-mediated inhibition of adipocyte differentiation. We prepared an inducible c-myc transformant of TA1 cells by transfection of the mouse c-myc gene under the control of the metallothionein-I promoter. These cells are unable to differentiate to adipocytes in the presence of Zn2+/Cd2+, and in differentiated TA1 cells, Zn2+/Cd2+ causes reduction of adipocyte-specific gene expression as does TNF. Lastly, exposure of TA1 cells to antisense c-myc oligonucleotide partially blocked the TNF-mediated reduction of adipocyte-specific gene expression. Thus, TNF-mediated c-myc expression is distinct in character from that involved in mitogenic responses but appears to play an important role in inhibition and reversal of adipocyte differentiation.
Both saccadic and manual responses in the amblyopic eye of strabismics are irreducibly delayed (2018)

Abnormal early visual development can result in a constellation of neural and visual deficits collectively known as amblyopia. Among the many deficits, a common finding is that both saccadic and manual reaction times to targets presented to the amblyopic eye are substantially delayed when compared to the fellow eye or to normal eyes. Given the well-known deficits in contrast sensitivity in the amblyopic eye, a natural question is whether the prolonged reaction times are simply a consequence of reduced stimulus visibility. To address this question, in Experiment 1 we measure saccadic reaction times (RT) to perifoveal stimuli as a function of effective stimulus contrast (i.e., contrast scaled by the amblyopic eye's contrast threshold). We find that when sensory differences between the eyes are minimized, the asymptotic RTs of our anisometropic amblyopes were similar in the two eyes. However, our results suggest that some strabismic amblyopes have an irreducible delay at the asymptote. That is, even when the sensory differences of the stimulus were accounted for, these observers still had large interocular differences (on average, 77 ms) in saccadic reaction time. In Experiment 2, to assess the role of fixation on saccadic reaction time we compared reaction time with and without a foveal target (the "gap effect"). Our results suggest that, while removing the fixation target does indeed speed up reaction time in the amblyopic eye, the gap effect is similar in the two eyes. Therefore, the gap effect does not eliminate the irreducible delay in the amblyopic eye. Finally, in Experiment 3 we compared the interocular differences in saccadic and manual reaction times in the same observers. This allowed us to determine the relationship between the latencies in the two modalities. We found a strong correlation between the differences in saccadic and manual reaction times; however, the manual RT difference is about half that of saccadic RT, suggesting that there may be two separable effects on saccadic reaction time: (a) a central problem with directing actions to a target, related to disengagement of attention at the fovea, which results in delays in both saccadic and manual reaction times, and (b) a further delay in saccadic reaction times because of the motor refractory period from a previous saccade or microsaccade, made in an attempt to stabilize the amblyopic eye of strabismics.
Subtype‐Selective Immunoprecipitation of the β2‐Adrenergic Receptor (1989)

Most antibodies known to interact with beta-adrenergic receptors do not exhibit subtype selectivity, nor do they provide quantitative immunoprecipitation. A monoclonal antibody, G27.1 raised against a synthetic peptide corresponding to the C-terminus of the beta 2-adrenergic receptor of hamster, is selective for the beta 2 subtype. G27.1 provides nearly quantitative immunoprecipitation of the beta 2-adrenergic receptor from hamster lung that has been photoaffinity-labeled and solubilized with sodium dodecyl sulfate. Immunoprecipitation is completely blocked by nanomolar concentrations of the immunizing peptide. This antibody interacts with beta 2-adrenergic receptors from three rodent species, but not with those from humans. When C6 glioma cells, which contain both beta 1- and beta 2-adrenergic receptors, are photoaffinity-labeled in the absence or presence of subtype-selective antagonists, subtype-selective photoaffinity-labeling results. G27.1 can immunoprecipitate beta 2-, but not beta 1-, adrenergic receptors from these cells. Similar results were obtained following subtype-selective photoaffinity-labeling of membranes from rat cerebellum and cerebral cortex. The beta-adrenergic receptors from C6 glioma cells and rat cerebral cortex exist as a mixture of two molecular weight species. These species differ in glycosylation, as shown by endoglycosidase F digestion of crude and immunoprecipitated receptors.
Cancer cell survival depends on collagen uptake into tumor-associated stroma (2022)

Collagen I, the most abundant protein in humans, is ubiquitous in solid tumors where it provides a rich source of exploitable metabolic fuel for cancer cells. While tumor cells were unable to exploit collagen directly, here we show they can usurp metabolic byproducts of collagen-consuming tumor-associated stroma. Using genetically engineered mouse models, we discovered that solid tumor growth depends upon collagen binding and uptake mediated by the TEM8/ANTXR1 cell surface protein in tumor-associated stroma. Tumor-associated stromal cells processed collagen into glutamine, which was then released and internalized by cancer cells. Under chronic nutrient starvation, a condition driven by the high metabolic demand of tumors, cancer cells exploited glutamine to survive, an effect that could be reversed by blocking collagen uptake with TEM8 neutralizing antibodies. These studies reveal that cancer cells exploit collagen-consuming stromal cells for survival, exposing an important vulnerability across solid tumors with implications for developing improved anticancer therapy.
Catheter ultrasound for cross-sectional imaging and drug delivery to vessel wall (2015)

Current methods for delivery of an anti-restenosis drug to an arterial vessel wall post-percutaneous transluminal angioplasty and stent placement are limited in terms of drug choice, dosing level, and ability to assure drug coverage between the struts of a drug eluting stent. Intravascular ultrasound (IVUS) provides real-time, radiation-free, imaging and assessment of atherosclerotic disease in terms of anatomical, functional and molecular information. In this presentation, the design of a dual imaging / therapy IVUS catheter is described and results documenting gene and drug delivery reported. Microbubbles and drug / gene (shell associated or co-injected) are dispensed from the catheter tip. Using this approach, it becomes possible to address the need for complete vessel wall coverage and achieve delivery in regions poorly addressed using conventional stent-based approaches. A range of in vitro, ex vivo and in vivo results are presented. Our most recent results involve a demonstration in a pig model of coronary balloon angioplasty that produced a 33% reduction in neointima formation versus a drug plus microbubble, but no ultrasound, control.
Analysis of random telegraph noise in spin valve heads with ultra-thin free layers (2001)

Random telegraph noise (RTN) in spin valve heads with ultra-thin free layers is analyzed in both time and frequency domain. RTN is characterized by random fluctuation between two meta-stable states and is attributed to thermally activated domain instability. Lifetime of each meta-stable state is changes with bias current, with both being equal when RTN amplitude peaks while asymmetry is near zero. The lifetime at equilibrium can be quantified by the flatness of RTN spectra and is correlated with the normalized peak area under RTN amplitude versus bias current curve. This area scales with the energy barrier associated with RTN. With the same RTN peak area, lifetime at equilibrium is shorter for heads with thinner free layers but otherwise the same structure. Impact on reader instability for ultra-high areal density recording is discussed.
The JPEG AI Standard: Providing Efficient Human and Machine Visual Data Consumption (2023)

The Joint Photographic Experts Group (JPEG) AI learning-based image coding system is an ongoing joint standardization effort between International Organization for Standardization (ISO), International Electrotechnical Commission (IEC), and International Telecommunication Union - Telecommunication Sector (ITU-T) for the development of the first image coding standard based on machine learning (a subset of artificial intelligence), offering a single stream, compact compressed domain representation, targeting both human visualization and machine consumption. The main motivation for this upcoming standard is the excellent performance of tools based on deep neural networks, in image coding, computer vision, and image processing tasks. The JPEG AI aims to develop an image coding standard addressing the needs of a wide range of applications such as cloud storage, visual surveillance, autonomous vehicles and devices, image collection storage and management, live monitoring of visual data, and media distribution. This article presents and discusses the rationale behind the JPEG AI vision, notably how this new standardization initiative aims to shape the future of image coding, through relevant application-driven use cases. The JPEG AI requirements, the JPEG AI history, and current status are also presented, offering a glimpse of the development of the first learning-based image coding standard.
Bidirectional Communication Between Microglia and Astrocytes inNeuroinflammation (2022)

Neuroinflammation is a common feature of diverse nervous system pathologies. In many instances, it begins at an early stage of the disease, paving the way for further exacerbations. The main drivers of neuroinflammation are brain-resident glial cells, such as microglia and astrocytes. Microglia are the primary responders to any insult to the brain parenchyma, translating the signals into diverse molecules. These molecules derived from microglia can regulate the stimuli-dependent reactivity of astrocytes. Once activated, astrocytes in turn, can control microglia phenotypes. Recent evidence indicates that the crosstalk between these glial cells plays an important role in delaying or accelerating neuroinflammation and overall disease progression. To date, various molecules have been recognized as key mediators of the bidirectional communication between microglia and astrocytes. The current review aims to discuss the novel molecules identified recently, which play a critical role in interglial crosstalk, highlighting their therapeutic potential.
Molecular structure of the discotic liquid crystalline phase of hexa-peri-hexabenzocoronene/oligothiophene hybrid and their charge transport properties (2015)

Using atomistic molecular dynamics simulation, we study the discotic columnar liquid crystalline (LC) phases formed by a new organic compound having hexa-peri-Hexabenzocoronene (HBC) core with six pendant oligothiophene units recently synthesized by Nan Hu et al. [Adv. Mater. 26, 2066 (2014)]. This HBC core based LC phase was shown to have electric field responsive behavior and has important applications in organic electronics. Our simulation results confirm the hexagonal arrangement of columnar LC phase with a lattice spacing consistent with that obtained from small angle X-ray diffraction data. We have also calculated various positional and orientational correlation functions to characterize the ordering of the molecules in the columnar arrangement. The molecules in a column are arranged with an average twist of 25° having an average inter-molecular separation of ∼5 Å. Interestingly, we find an overall tilt angle of 43° between the columnar axis and HBC core. We also simulate the charge transport through this columnar phase and report the numerical value of charge carrier mobility for this liquid crystal phase. The charge carrier mobility is strongly influenced by the twist angle and average spacing of the molecules in the column.
Spatiotemporal changes in influenza A virus prevalence among wild waterfowl inhabiting the continental United States throughout the annual cycle (2022)

Avian influenza viruses can pose serious risks to agricultural production, human health, and wildlife. An understanding of viruses in wild reservoir species across time and space is important to informing surveillance programs, risk models, and potential population impacts for vulnerable species. Although it is recognized that influenza A virus prevalence peaks in reservoir waterfowl in late summer through autumn, temporal and spatial variation across species has not been fully characterized. We combined two large influenza databases for North America and applied spatiotemporal models to explore patterns in prevalence throughout the annual cycle and across the continental United States for 30 waterfowl species. Peaks in prevalence in late summer through autumn were pronounced for dabbling ducks in the genera Anas and Spatula, but not Mareca. Spatially, areas of high prevalence appeared to be related to regional duck density, with highest predicted prevalence found across the upper Midwest during early fall, though further study is needed. We documented elevated prevalence in late winter and early spring, particularly in the Mississippi Alluvial Valley. Our results suggest that spatiotemporal variation in prevalence outside autumn staging areas may also represent a dynamic parameter to be considered in IAV ecology and associated risks.