gebhart/patrepeval huggingface dataset:
Asymptotic Analysis of Complex LASSO via Complex Approximate Message Passing (CAMP) (2011)

Recovering a sparse signal from an undersampled set of random linear measurements is the main problem of interest in compressed sensing. In this paper, we consider the case where both the signal and the measurements are complex. We study the popular reconstruction method of $\ell_1$-regularized least squares or LASSO. While several studies have shown that the LASSO algorithm offers desirable solutions under certain conditions, the precise asymptotic performance of this algorithm in the complex setting is not yet known. In this paper, we extend the approximate message passing (AMP) algorithm to the complex signals and measurements and obtain the complex approximate message passing algorithm (CAMP). We then generalize the state evolution framework recently introduced for the analysis of AMP, to the complex setting. Using the state evolution, we derive accurate formulas for the phase transition and noise sensitivity of both LASSO and CAMP.
Generation of osteogenic construct using periosteal‐derived osteoblasts and polydioxanone/pluronic F127 scaffold with periosteal‐derived CD146 positive endothelial‐like cells (2012)

The purpose of this study was to generate tissue-engineered bone using human periosteal-derived osteoblasts (PO) and polydioxanone/pluronic F127 (PDO/pluronic F127) scaffold with preseeded human periosteal-derived CD146 positive endothelial-like cells (PE). PE were purified from the periosteal cell population by cell sorting. One of the important factors to consider in generating tissue-engineered bone using osteoprecursor and endothelial cells and a specific scaffold is whether the function of osteoprecursor and endothelial cells can be maintained in originally different culture medium conditions. After human PE were preseeded into PDO/pluronic F127 scaffold and cultured in endothelial cell basal medium-2 for 7 days, human PO were seeded into the PDO/pluronic F127 scaffold with PE, and then, this cell-scaffold construct was cultured in endothelial cell basal medium-2 with osteogenic induction factors, including ascorbic acid, dexamethasone, and β-glycerophosphate, for a further 7 days. Then, this 2-week cultured construct was grafted into the mandibular defect of miniature pig. Twelve weeks after implantation, the animal was sacrificed. Clinical examination revealed that newly formed bone was seen more clearly in the defect with human PO and PDO/pluronic F127 scaffold with preseeded human PE. The experimental results suggest that tissue-engineered bone formation using human PO and PDO/pluronic F127 scaffold with preseeded human PE can be used to restore skeletal integrity to various bony defects when used in clinics.
Figure S6 from Computational Staining of Pathology Images to Study the Tumor Microenvironment in Lung Cancer (2023)

&lt;p&gt;Supplemental Figure S6. Validation of macrophage detection results in whole-slide image nuclei segmentation and classification by HD-Staining model.&lt;/p&gt;
Ring-Based WDM-PON with Suppression of Rayleigh Backscattering Interferometric Noise (2011)

We demonstrate a ring-based WDM-PON. Rayleigh-backscattering (RB) can be suppressed since the upstream signal and the RB are traveling in different directions. We also analyze the network performance when upgrading to 40-Gb/s. ©2011 Optical Society of America
Magnet Temperature Estimation in Surface PM Machines During Six-Step Operation (2012)

This paper presents a method for estimating the magnet temperature in surface permanent-magnet (PM) synchronous machines during six-step operation. Six-step operation allows the maximum available dc-bus voltage to be applied to a machine, which maximizes its torque and speed range. This can be of importance in electric traction applications, including railway as well as electric and hybrid electric vehicles. However, six-step operation produces current harmonics that induce additional losses in the PMs and can therefore increase their temperature. An increase of magnet temperature can result in a reduced torque capability and eventually in a risk of demagnetization if excessive values are reached, with real-time rotor magnet temperature monitoring being therefore advisable. Six-step operation provides opportunities for rotor temperature monitoring from the electrical terminal variables (voltages and currents) of the motor. To achieve this goal, the rotor high-frequency resistance is measured using the harmonic voltages and currents due to six-step operation, from which the magnet temperature can be estimated.
A Hypomorphic Dars1D367Y Model Recapitulates Key Aspects of the Leukodystrophy HBSL (2021)

Hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL) is a leukodystrophy caused by missense mutations of the aspartyl-tRNA synthetase-encoding gene <i>DARS1</i>. The clinical picture includes the regression of acquired motor milestones, spasticity, ataxia, seizures, nystagmus, and intellectual disabilities. Morphologically, HBSL is characterized by a distinct pattern of hypomyelination in the central nervous system including the anterior brainstem, the cerebellar peduncles and the supratentorial white matter as well as the dorsal columns and the lateral corticospinal tracts of the spinal cord. Adequate HBSL animal models are lacking. <i>Dars1</i> knockout mice are embryonic lethal precluding examination of the etiology. To address this, we introduced the HBSL-causing <i>Dars1</i> <sup><i>D</i>367<i>Y</i></sup> point mutation into the mouse genome. Surprisingly, mice carrying this mutation homozygously were phenotypically normal. As hypomorphic mutations are more severe in trans to a deletion, we crossed <i>Dars1</i> <sup><i>D</i>367<i>Y</i>/<i>D</i>367<i>Y</i></sup> mice with <i>Dars1-null</i> carriers. The resulting <i>Dars1</i> <sup><i>D</i>367<i>Y</i>/-</sup> offspring displayed a strong developmental delay compared to control <i>Dars1</i> <sup><i>D</i>367<i>Y</i>/+</sup> littermates, starting during embryogenesis. Only a small fraction of <i>Dars1</i> <sup><i>D</i>367<i>Y</i>/-</sup> mice were born, and half of these mice died with hydrocephalus during the first 3 weeks of life. Of the few <i>Dars1</i> <sup><i>D</i>367<i>Y</i>/-</sup> mice that were born at term, 25% displayed microphthalmia. Throughout postnatal life, <i>Dars1</i> <sup><i>D</i>367<i>Y</i>/-</sup> mice remained smaller and lighter than their <i>Dars1</i> <sup><i>D</i>367<i>Y</i>/+</sup> littermates. Despite this early developmental deficit, once they made it through early adolescence <i>Dars1</i> <sup><i>D</i>367<i>Y</i>/-</sup> mice were phenotypically inconspicuous for most of their adult life, until they developed late onset motor deficits as well as vacuolization and demyelination of the spinal cord white matter. Expression levels of the major myelin proteins were reduced in <i>Dars1</i> <sup><i>D</i>367<i>Y</i>/-</sup> mice compared to controls. Taken together, <i>Dars1</i> <sup><i>D</i>367<i>Y</i>/-</sup> mice model aspects of the clinical picture of the corresponding missense mutation in HBSL. This model will enable studies of late onset deficits, which is precluded in <i>Dars1</i> knockout mice, and can be leveraged to test potential HBSL therapeutics including <i>DARS1</i> gene replacement therapy.
Manipulating Nanoscale Interactions in a Polymer Nanocomposite for Chiral Control of Linear and Nonlinear Optical Functions (2013)

The design, synthesis, and supramolecular organization of a nanocomposite in which nanoscale excitonic interactions between quantum dots and the chiral polymer dramatically enhance the optical activity is reported. This material is highly suitable for application in the emerging field of chiral photonics.
The laser-generated ultrasonic phased array: Analysis and experiments (1993)

Focused ultrasonic waves have been generated in a solid by irradiating its surface with a multiple beam-pulsed YAG laser. A set of 16 rectilinear sources is used, equivalent to a phased array of ultrasonic transducers. Longitudinal waves are focused in the sample by introducing an appropriate time delay between each laser pulse. The elastic waves are detected either by a broadband optical heterodyne probe to analyze the wide ultrasonic signal spectrum (0–20 MHz), or by a narrow-band piezoelectric transducer to achieve the sectorial acoustic beam scanning of the sample. Neglecting heat diffusion in the solid and considering the source as a surface center of expansion, the impulse directivity patterns of laser-generated longitudinal acoustic waves have been computed. Experiments performed on duraluminum samples in the thermoelastic regime and steel samples in the ablation regime are presented and compared with this analysis. It is shown that a high focusing and a significant improvement of the signal sensitivity for longitudinal waves can be achieved with this technique.
Synthesis and Thermal Properties of Hydrogenated Poly(styrene-co-1,1-diphenylethylene) Copolymers (2003)

ADVERTISEMENT RETURN TO ISSUEPREVNoteSynthesis and Thermal Properties of Hydrogenated Poly(styrene-co-1,1-diphenylethylene) CopolymersJing J. Xu and Frank S. BatesView Author Information Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455 Cite this: Macromolecules 2003, 36, 14, 5432–5434Publication Date (Web):June 10, 2003Publication History Received23 January 2003Revised6 May 2003Published online10 June 2003Published inissue 1 July 2003https://pubs.acs.org/doi/10.1021/ma030057ghttps://doi.org/10.1021/ma030057gbrief-reportACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views387Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalytic reactions,Copolymers,Hydrogenation,Monomers,Styrenes Get e-Alerts
High-resolution phase distortion compensation in adaptive interferometers (1998)

High resolution adaptive phase distortion suppression was experimentally demonstrated for laser interferometers using a liquid crystal television as a phase modulator and an opto-electronic feedback loop. The experiments were carried out for both amplitude division and rotational shear types of interferometers. The suggested iterative control algorithm is based solely on interference pattern information. The results of numerical simulations of a high resolution adaptive system based on rotational shear type interferometers show the system's potential for atmospheric turbulence phase distortion suppression.
Compositions and methods for inducing HIV-1 antibodies (2023)

In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH0848) and selections there—from, and methods for swarm immunizations using combinations of HIV-1 envelopes.
Radio-frequency inverters with transmission-line input networks (2006)

A soft-switching inverter topology (the Class Φ) is presented which draws dc source current through a transmission line or a lumped-network approximation of a distributed line. By aligning the inverter switching frequency just below the line's λ/4-wave resonance, the Class Φ topology enforces odd-and even-harmonic content in its drain voltage and input current, respectively. The symmetrizing action of the transmission-line dynamics results in natural square-wave operation of the switch, reducing the inverter stresses (relative to a Class E) for a given power throughput. The inverter waveforms and normalized power-output capability are analyzed in simple terms, and supported by measurements of an inverter built around a length of distributed line, and an inverter incorporating a lumped L-C ladder network. The latter implementation is constructed with air-core magnetics and inter-layer capacitances that are integrated into the thickness of a printed-circuit board. A comparison with a Class Ε inverter of similar size and ratings demonstrates the small passive-component values and manufacturing advantages afforded by the Class Φ topology.
Inhibition of Mitochondrial Na+-Ca2+ Exchanger Increases Mitochondrial Metabolism and Potentiates Glucose-Stimulated Insulin Secretion in Rat Pancreatic Islets (2003)

The mitochondrial Na(+)-Ca(2+) exchanger (mNCE) mediates efflux of Ca(2+) from mitochondria in exchange for influx of Na(+). We show that inhibition of the mNCE enhances mitochondrial oxidative metabolism and increases glucose-stimulated insulin secretion in rat islets and INS-1 cells. The benzothiazepine CGP37157 inhibited mNCE activity in INS-1 cells (50% inhibition at IC(50) = 1.5 micro mol/l) and increased the glucose-induced rise in mitochondrial Ca(2+) ([Ca(2+)](m)) 2.1 times. Cellular ATP content was increased by 13% in INS-1 cells and by 49% in rat islets by CGP37157 (1 micro mol/l). Krebs cycle flux was also stimulated by CGP37157 when glucose was present. Insulin secretion was increased in a glucose-dependent manner by CGP37157 in both INS-1 cells and islets. In islets, CGP37157 increased insulin secretion dose dependently (half-maximal efficacy at EC(50) = 0.06 micro mol/l) at 8 mmol/l glucose and shifted the glucose dose response curve to the left. In perifused islets, mNCE inhibition had no effect on insulin secretion at 2.8 mmol/l glucose but increased insulin secretion by 46% at 11 mmol/l glucose. The effects of CGP37157 could not be attributed to interactions with the plasma membrane sodium calcium exchanger, L-type calcium channels, ATP-sensitive K(+) channels, or [Ca(2+)](m) uniporter. In hyperglycemic clamp studies of Wistar rats, CGP37157 increased plasma insulin and C-peptide levels only during the hyperglycemic phase of the study. These results illustrate the potential utility of agents that affect mitochondrial metabolism as novel insulin secretagogues.
Bioactive Phenolic Compounds from a Medicinal Lichen, Usnea longissima. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Body Surface Electrocardiographic Mapping for Non-invasive Identification of Arrhythmic Sources (2013)

The authors describe a novel three-dimensional, 252-lead electrocardiography (ECG) and computed tomography (CT)-based non-invasive cardiac imaging and mapping modality. This technique images potentials, electrograms and activation sequences (isochrones) on the epicardial surface of the heart. This tool has been investigated in the normal cardiac electrophysiology and various tachyarrhythmic, conduction and anomalous depo-repolarisation disorders. The clinical application of this system includes a wide range of electrical disorders like atrial arrhythmias (premature atrial beat, atrial tachycardia, atrial fibrillation), ventricular arrhythmias (premature ventricular beat, ventricular tachycardia) and ventricular pre-excitation (Wolff-Parkinson-White syndrome). In addition, the system has been used in exploring abnormalities of the His-Purkinje conduction like the bundle branch block and intraventricular conduction disturbance and thereby useful in electrically treating the associated heart failure (cardiac resynchronisation). It has a potential role in furthering our understanding of abnormalities of ventricular action potential (depolarisation [Brugada syndrome and repolarisation], long QT and early repolarisation syndromes) and in evaluating the impact of drugs on His-Purkinje conduction and cardiac action potential.
ChemInform Abstract: OPIOID PEPTIDES. VIII. SYNTHESIS AND PRELIMINARY BIOLOGICAL ACTIVITY OF (D‐PHE3)‐ OR (α,β‐DEHYDRO‐PHE3)DERMORPHIN TETRAPEPTIDES (1985)

We describe the synthesis and preliminary in vitro pharmacological testing of two new tetrapeptide analogues of the opioid heptapeptide dermorphin H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2. The replacement of Phe3 by its D-enantiomer was hardly if at all tolerated. The unsaturated analogue carrying the phenyl ring of the delta Phe3 residue in the Z-configuration, was almost inactive.
A Crosstalk between the Biorhythms and Gatekeepers of Longevity: Dual Role of Glycogen Synthase Kinase-3 (2021)

This review discusses genetic and molecular pathways that link circadian timing with metabolism, resulting in the emergence of positive and negative regulatory feedback loops. The Nrf2 pathway is believed to be a component of the anti-aging program responsible for the healthspan and longevity. Nrf2 enables stress adaptation by activating cell antioxidant defense and other metabolic processes via control of expression of over 200 target genes in response to various types of stress. The GSK3 system represents a "regulating valve" that controls fine oscillations in the Nrf2 level, unlike Keap1, which prevents significant changes in the Nrf2 content in the absence of oxidative stress and which is inactivated by the oxidative stress. Furthermore, GSK3 modifies core circadian clock proteins (Bmal1, Clock, Per, Cry, and Rev-erbα). Phosphorylation by GSK3 leads to the inactivation and degradation of circadian rhythm-activating proteins (Bmal1 and Clock) and vice versa to the activation and nuclear translocation of proteins suppressing circadian rhythms (Per and Rev-erbα) with the exception of Cry protein, which is likely to be implicated in the fine tuning of biological clock. Functionally, GSK3 appears to be one of the hubs in the cross-regulation of circadian rhythms and antioxidant defense. Here, we present the data on the crosstalk between the most powerful cell antioxidant mechanism, the Nrf2 system, and the biorhythm-regulating system in mammals, including the impact of GSK3 overexpression and knockout on the Nrf2 signaling. Understanding the interactions between the regulatory cascades linking homeostasis maintenance and cell response to oxidative stress will help in elucidating molecular mechanisms that underlie aging and longevity.
<title>Haptic control of the hand force feedback system</title> (1999)

The Hand Force Feedback System is an anthropomorphic haptic interface for the replication of the forces arising during grasping and fine manipulation operations. It is composed of four independent finger dorsal exoskeletons which wrap up four fingers of the human hand (the little finger is excluded). Each finger possesses three electrically actuated DOF placed in correspondence with the human finger flexion axes and a passive DOF allowing finger abduction movements.
Chapter 5.1. MRI Contrast Agents: Synthesis, Applications and Perspectives (2011)

Magnetic Resonance Imaging (MRI) is a well-established diagnostic technique which allows images to be obtained of the inside of the human body. For several MRI procedures, to increase the quality and resolution of the images, a contrast agent is administered to the patient. Among the available MRI contrast agents, those based on the paramagnetic gadolinium ion are the most widely employed. The syntheses and applications of the MRI contrast agents currently available on the market are reviewed and discussed. Moreover, new perspectives in this field, such as responsive and bioactivating agents, macromolecular and supramolecular systems, and agents for innovative MRI approaches, are highlighted.
Integrated angular tracking and plasmonic membrane surfaces for a point of a care refractive index sensor (2016)

We present an optical system which integrates a plasmonic sensing surface and an angular tracking system to enable a compact refractive index measurement. A refractive index change at the surface of the sensing membrane causes a change in the angle at which monochromatic light is transmitted through the membrane. This transmission angle is measured by the angular tracking system. We show good theoretical and experimental agreement of the transmission of the plasmonic sensing surface at different angular illumination of the membranes. Using this compact optical setup the embedded angular tracking system has an accuracy of &lt;10<sup>-4</sup> deg. This corresponds to a sensitivity &lt;10<sup>-5</sup> refractive index units. Finally we demonstrate this measurement technique using different concentrations of saline solution.
Shear stress induces a transient and VEGFR-2-dependent decrease in the motion of injected particles in endothelial cells (2010)

Vascular endothelial cells form the inner lining of all blood vessels and play a central role in vessel physiology and disease. Endothelial cells are highly responsive to the mechanical stimulus of fluid shear stress that is exerted by blood flowing over their surface. In this study, the immediate micromechanical response of endothelial cells to physiological shear stress was characterized by tracking of ballistically injected, sub-micron, fluorescent particles. It was found that the mean squared displacement (MSD) of the particles decreases by a factor 1.5 within 10 min after the onset of shear stress. This decrease in particle motion is transient, since the MSD returns to control values within 15-30 min after the onset of shear. The immediate micromechanical stiffening is dependent on activation of the vascular endothelial growth factor receptor (VEGFR)-2, because inhibition of the receptor abrogates the micromechanical response. This work shows that the cytoskeleton is actively involved in the acute, functional response of endothelial cells to shear stress.