gebhart/patrepeval huggingface dataset:
Synthesis and Characterization of Diaminophenylindane Based Polyimides via Ester-Acid Solution Imidization (1997)

The solution polycondensation of 1-(4-aminophenyl)-5(6)-aminoindane (DAPI) with a number of commercially available dianhydrides using the two-step ester-acid solution imidization route is described. High molecular weight polyimides were successfully synthesized from a 1:1 molar ratio of dianhydride to diamine. These film-forming systems have high glass transition temperatures (331–368 °C) and very good short-term thermal stability as judged by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA). The fully cyclized polyimides are also highly soluble in common solvents.
Material Protection, Accounting, and Control Technologies (MPACT): Modeling and Simulation Roadmap (2016)

The development of sustainable advanced nuclear fuel cycles is a long-term goal of the Office of Nuclear Energy’s (DOE-NE) Fuel Cycle Technologies program. The Material Protection, Accounting, and Control Technologies (MPACT) campaign is supporting research and development (R&D) of advanced instrumentation, analysis tools, and integration methodologies to meet this goal. This advanced R&D is intended to facilitate safeguards and security by design of fuel cycle facilities. The lab-scale demonstration of a virtual facility, distributed test bed, that connects the individual tools being developed at National Laboratories and university research establishments, is a key program milestone for 2020. These tools will consist of instrumentation and devices as well as computer software for modeling. To aid in framing its long-term goal, during FY16, a modeling and simulation roadmap is being developed for three major areas of investigation: (1) radiation transport and sensors, (2) process and chemical models, and (3) shock physics and assessments. For each area, current modeling approaches are described, and gaps and needs are identified.
Untreated PKU patients without intellectual disability: SHANK gene family as a candidate modifier (2021)

Phenylketonuria (PKU) is an inborn error of metabolism caused by variants in the phenylalanine hydroxylase (<i>PAH</i>) gene and it is characterized by excessively high levels of phenylalanine in body fluids. PKU is a paradigm for a genetic disease that can be treated and majority of developed countries have a population-based newborn screening. Thus, the combination of early diagnosis and immediate initiation of treatment has resulted in normal intelligence for treated PKU patients. Although PKU is a monogenic disease, decades of research and clinical practice have shown that the correlation between the genotype and corresponding phenotype is not simple at all. Attempts have been made to discover modifier genes for PKU cognitive phenotype but without any success so far. We conducted whole genome sequencing of 4 subjects from unrelated non-consanguineous families who presented with pathogenic mutations in the <i>PAH</i> gene, high blood phenylalanine concentrations and near-normal cognitive development despite no treatment. We used cross sample analysis to select genes common for more than one patient. Thus, the <i>SHANK</i> gene family emerged as the only relevant gene family with variants detected in 3 of 4 analyzed patients. We detected two novel variants, p.Pro1591Ala in <i>SHANK1</i> and p.Asp18Asn in <i>SHANK2</i>, as well as <i>SHANK2</i>:p.Gly46Ser, <i>SHANK2</i>:p.Pro1388_Phe1389insLeuPro and <i>SHANK3</i>:p.Pro1716Thr variants that were previously described. Computational analysis indicated that the identified variants do not abolish the function of SHANK proteins. However, changes in posttranslational modifications of SHANK proteins could influence functioning of the glutamatergic synapses, cytoskeleton regulation and contribute to maintaining optimal synaptic density and number of dendritic spines. Our findings are linking <i>SHANK</i> gene family and brain plasticity in PKU for the first time. We hypothesize that variant SHANK proteins maintain optimal synaptic density and number of dendritic spines under high concentrations of phenylalanine and could have protective modifying effect on cognitive development of PKU patients.
Enhanced offline secondary path modeling method for narrowband active noise control system (2016)

This paper analyzes the performance of off-line secondary path modeling algorithms for narrowband active noise control (ANC) systems. The accuracy and convergence rate of adaptive system identification will be degraded by disturbance. A delayless filterbank is utilized to partition the full-band excitation and error signals in order to reduce the order of the secondary-path model and increase the convergence rate of the parallel-structure narrowband ANC system. The improved performance is verified by computer simulations using measured transfer functions from the experimental setup.
A Neoplasm with Pancreatic and Hepatocellular Differentiation Presenting with Subcutaneous Fat Necrosis (1987)

A neoplasm demonstrating both pancreatic and hepatic phenotypes is described. The tumor, from a 53-year-old woman with the syndrome of subcutaneous fat necrosis and arthropathy, was studied histologically, immunohistochemically, ultrastructurally, and biochemically. The clinical features of this case can be explained by the production of large amounts of lipase by the tumor. The hepatocellular properties of the tumor included characteristic morphology and the synthesis of catalase. The pancreatic properties of the tumor included the production of pancreatic lipase. This neoplasm would appear to be analogous to animal models in which the transdifferentiation of pancreatic acinar cells and hepatocytes has been demonstrated. Although the bulk of the tumor was present in the liver, the authors believe the tumor arose from the pancreas. The distinction between differentiation and site of origin of tumors is discussed.
Titelbild: Chemically Programmed Supramolecular Assembly of Hemoprotein and Streptavidin with Alternating Alignment (Angew. Chem. 16/2012) (2012)

Ein alternierendes Proteinassoziat aus dem Myoglobin-Dimer (grün) und Streptavidin (grau) wurde mithilfe einer synthetisierten Cofaktor-Dyade mit einer flexiblen Brücke zwischen einer Hämgruppe (rot) und einer Bis(biotin)-Einheit (blau) erhalten. Die spezifischen Wechselwirkungen zwischen diesen drei Komponenten führten zu einem supramolekularen, submikrometergroßen, faserförmigen Assoziat, das mit AFM analysiert wurde, wie T. Hayashi, T. R. Ward et al. in der Zuschrift auf S. 3884 ff. berichten.
Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories (2016)

Fear can be highly adaptive in promoting survival, yet it can also be detrimental when it persists long after a threat has passed. Flexibility of the fear response may be most advantageous during adolescence when animals are prone to explore novel, potentially threatening environments. Two opposing adolescent fear-related behaviours-diminished extinction of cued fear and suppressed expression of contextual fear-may serve this purpose, but the neural basis underlying these changes is unknown. Using microprisms to image prefrontal cortical spine maturation across development, we identify dynamic BLA-hippocampal-mPFC circuit reorganization associated with these behavioural shifts. Exploiting this sensitive period of neural development, we modified existing behavioural interventions in an age-specific manner to attenuate adolescent fear memories persistently into adulthood. These findings identify novel strategies that leverage dynamic neurodevelopmental changes during adolescence with the potential to extinguish pathological fears implicated in anxiety and stress-related disorders.
High Conductivity and Flexible Hybrid Solid State Electrolyte (Final Report: DOE-EE0007807) (2019)

The project objective is to develop flexible hybrid electrolyte with garnet nanofibers to achieve the following: (1) flexible, with greater mechanical strength (~ 10 MPa) and thermal stability than polymer electrolytes; (2) high room-temperature ionic conductivity, ~ 0.5 mS/cm; (3) stable interface with lithium metal and effective blocking of lithium dendrites at current densities up to 3 mA/cm2; and (4) battery performance with Li S chemistry with an energy density of ≥ 450 Wh/kg (and ≥ 1000 Wh/L) and maintaining ≥ 80% of capacity up to 500 cycles. We synthesized garnet nanofibers, filled the porous region with polymer electrolyte, and characterized and tuned the flexible hybrid membrane properties. The flexible hybrid SSE microstructure was analyzed by leveraging the UMD AIMLab Focused Ion Beam Scanning Electron Microscopy (FIB-SEM) tools and integrated with electrochemical methods at the UMERC Battery Fabrication Lab to investigate the properties and stability with Li metal anode. We developed a fundamental understanding of the mechanism of Li ionic diffusion in garnet nanofibers and their mechanical properties, as well as these properties for hybrid garnet-fiber/polymer hybrids. Work progressed toward the study of the electrode assembly during electrochemical cycling of the anode.
Effect of Implementing Dental Services in Israeli Psychiatric Hospitals on the Oral and Dental Health of Inpatients (2009)

The results suggest a substantial improvement in the dental health of this at-risk population after the dental reform in psychiatric hospitals. However, oral health needs are still not fully met, and therefore, additional organizational efforts for further prevention and treatment of dental diseases are required.
Broadband imaging with one planar diffractive lens (2018)

We demonstrate imaging over the visible band using a single planar diffractive lens. This is enabled via multi-level diffractive optics that is designed to focus over a broad wavelength range, which we refer to as an achromatic diffractive lens (ADL). We designed, fabricated and characterized two ADLs with numerical apertures of 0.05 and 0.18. Diffraction-limited focusing is demonstrated for the NA = 0.05 lens with measured focusing efficiency of over 40% across the entire visible spectrum (450 nm to 750 nm). We characterized the lenses with a monochromatic and a color CMOS sensor, and demonstrated video imaging under natural sunlight and other broadband illumination conditions. We use rigorous electromagnetic simulations to emphasize that ADLs can achieve high NA (0.9) and large operating bandwidth (300 nm in the visible spectrum), a combination of metrics that have so far eluded other flat-lens technologies such as metalenses. These planar diffractive lenses can be cost-effectively manufactured over large areas and thereby, can enable the wide adoption of flat, low-cost lenses for a variety of imaging applications.
Selective eradication of cancer cells by delivery of adenovirus-based toxins (2017)

A proof of concept for a novel cancer safe and effective gene therapy exploiting an aberrant hyperactive pathway is achievable.
Screening for MAPK Modulators Using an In-Cell Western Assay (2013)

Several essential cellular functions are critically influenced by the Ras-Raf-MEK-ERK cascade, and pathological problems have been implicated with loss as well as gain of its activity. Therefore, there is a great demand for chemical probes that act as modulators of the cascade in order to correct medical problems associated with its malfunctions. Here we describe the use of the In-Cell Western assay, a fast and easy method for the detection of ERK activity. This method is useful for the screening of chemical libraries for compounds that modulate the intensity and duration of growth factor-induced MAPK activity. Examples are provided from a screen for MAPK modulators in Vichem Chemie Research´s Nested Chemical Library™.
Crosstalk Analysis of FSK Light Label on 112 Gbps DP-QPSK Signal in CNCG ROADM Network (2014)

We investigated crosstalk of FSK supervisory channel superimposed on a 112 Gbps DP-QPSK caused by pass-band narrowing effect in CNCG ROADM network. We estimated maximum number of ROADM nodes and frequency misalignment tolerance between main signal and center frequency of WSS pass-band that the FSK light label technique could support.
Identification of novel QTL for resistance to Fusarium head blight in a tetraploid wheat population (2012)

Most tetraploid durum wheat (Triticum turgidum L var. durum) cultivars are susceptible to Fusarium head blight (FHB). This study reports novel quantitative trait loci (QTL) associated with FHB resistance. A backcross recombinant inbred line (BCRIL) population was developed from the cross BGRC3487/2*DT735, and 160 lines were evaluated for resistance to Fusarium graminearum Schwabe (teleomorph Gibberella zeae (Schwein. Petch) in field trials over 3 years (2008-2010) and to a F. graminearum 3-acetyl-deoxynivalenol (3-ADON) chemotype in greenhouse trials. The population was genotyped with 948 polymorphic loci using DArT and microsatellite markers. Eleven QTL were associated with FHB resistance under field conditions on chromosomes 2A, 3B, 5A, 5B, 7A, and 7B. Two of these, QFhb.usw-3B from BGRC3487 and QFhb.usw-7A2, were consistently detected over environments. The QFhb.usw-3B QTL was in a similar position to a resistance QTL in hexaploid wheat. The combination of the two QTL reduced field index by 53.5%-86.2%. Two QTL for resistance to the 3-ADON chemotype were detected on chromosomes 1B and 4B. Both BGRC3487 and DT735 could provide new sources of FHB resistance and the combination of QTL reported here could be valuable tools in breeding FHB-resistant durum wheat.
Supplementary Figure 5 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells (2023)

&lt;p&gt;PDF file - 47K, 5A, The oxidative stress indicator HMOX1 expressed in wild-type MCF-7 cells after E2 treatment. Wild-type MCF-7 cells were cultured in E2 free medium for three days. Then, cells were plated in six-well plates. After one day, cells were treated with vehicle (0.1% EtOH) and E2 (10-9 mol/L) for different time points as indicated and the cells were harvested in TRIzol for real-time PCR. P&lt;0.001, ** compared with control. 5B, The oxidative stress indicator HMOX1 expressed in long-term E2 deprived MCF-7:2A cells after E2 treatment. MCF-7:2A cells were plated in six-well plates. After one day, cells were treated with vehicle (0.1% EtOH) and E2 (10-9 mol/L) for different time points as indicated and the cells were harvested in TRIzol for real-time PCR. P&lt;0.05, * compared with control. 5C, The oxidative stress indicator HMOX1 expressed in long-term E2 deprived MCF-7:5C cells after E2 treatment. MCF-7:5C cells were plated in six-well plates. After one day, cells were treated with vehicle (0.1% EtOH) and E2 (10-9 mol/L) for different time points as indicated and the cells were harvested in TRIzol for real-time PCR. P&lt;0.05, * compared with control. P&lt;0.001, ** compared with control.&lt;/p&gt;
A two‐dimensional feasibility study of deep learning‐based feature detection and characterization directly from CT sinograms (2019)

Machine Learning, especially deep learning, has been used in typical x-ray computed tomography (CT) applications, including image reconstruction, image enhancement, image domain feature detection and image domain feature characterization. To our knowledge, this is the first study on machine learning for feature detection and analysis directly based on CT projection data. Specifically, we present neural network methods for blood vessel detection and characterization in the sinogram domain avoiding any partial volume, beam hardening, or motion artifacts introduced during reconstruction. First, we estimate sinogram domain vessel maps using a residual encoder-decoder convolutional neural network (REDCNN). Next, we estimate the vessel centerline and we extract the vessel-only sinogram from the original sinogram, eliminating any background information. Finally, we use a fully connected neural network to estimate the vessel lumen cross-sectional area from the vessel-only sinogram. We trained and tested the proposed methods using CatSim simulations, real CT measurements of vessel phantoms, and clinical data from the NIH CT image database. We achieved encouraging initial results showing the feasibility of CT analysis in the sinogram domain. In principle, sinogram domain analysis should be possible for many other and more complicated clinical CT analysis tasks. Further studies are needed for this sinogram domain analysis approach to become practical for clinical applications.
Data from LIM Kinase Inhibitor Pyr1 Reduces the Growth and Metastatic Load of Breast Cancers (2023)

&lt;div&gt;Abstract&lt;p&gt;LIM kinases (LIMK) are emerging targets for cancer therapy, and they function as network hubs to coordinate actin and microtubule dynamics. When LIMKs are inhibited, actin microfilaments are disorganized and microtubules are stabilized. Owing to their stabilizing effect on microtubules, LIMK inhibitors may provide a therapeutic strategy to treat taxane-resistant cancers. In this study, we investigated the effect of LIMK inhibition on breast tumor development and on paclitaxel-resistant tumors, using a novel selective LIMK inhibitor termed Pyr1. Treatment of breast cancer cells, including paclitaxel-resistant cells, blocked their invasion and proliferation &lt;i&gt;in vitro&lt;/i&gt; and their growth &lt;i&gt;in vivo&lt;/i&gt; in tumor xenograft assays. The tumor-invasive properties of Pyr1 were investigated &lt;i&gt;in vivo&lt;/i&gt; by intravital microscopy of tumor xenografts. A striking change of cell morphology was observed with a rounded phenotype arising in a subpopulation of cells, while other cells remained elongated. Notably, although Pyr1 decreased the motility of elongated cells, it increased the motility of rounded cells in the tumor. Pyr1 administration prevented the growth of metastasis but not their spread. Overall, our results provided a preclinical proof of concept concerning how a small-molecule inhibitor of LIMK may offer a strategy to treat taxane-resistant breast tumors and metastases. &lt;i&gt;Cancer Res; 76(12); 3541–52. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Le partage des rôles et des responsabilités à l'égard du pilotage des communautés de pratique (2010)

Résumé Une communauté de pratique correspond à un groupement d’individus partageant un intérêt commun et échangeant entre eux leurs connaissances et leurs compétences de manière créatrice afin d’accroître la performance de l’organisation. Les communautés de pratique prennent depuis quelques années une place croissante au sein des organisations. Pourtant, nous en savons peu sur le partage optimal des rôles et des responsabilités entre divers acteurs eu égard à la création et à la gestion de ces communautés. En nous basant sur deux études de cas, nous indiquons que le partage des rôles et des responsabilités évolue en fonction du stade d’évolution des communautés de pratique. Puis, nous recommandons des rôles à l’égard de trois grands acteurs. Dans le cas des parrains ou de la haute direction, il s’agit d’appuyer l’existence de la communauté et de lui donner un souffle, de promouvoir les connaissances que la communauté produit et de réduire son engagement avec l’évolution de la communauté. Dans le cas des animateurs, il s’agit de construire l’identité de la communauté et de veiller sur les échanges qui y ont lieu, de moduler leur engagement selon l’évolution de la communauté et de gérer le transfert des rôles et des responsabilités aux membres de la communauté. Enfin, dans le cas des membres participants et des techniciens, il s’agit de participer aux échanges dans la communauté et de faciliter ceux-ci de même que d’accroître leur engagement avec l’évolution de la communauté. Fonctions : management, GRH, TI
Hysteresis Contributions in Carbon Black-Filled Rubbers Containing Conventional and Tin End-Modified Polymers (1998)

Abstract A methodology was developed to estimate individual hysteresis contributions arising from the carbon black network, polymer free chain ends and effective polymer network chains. The estimation technique was applied to rubber compounds formulated with linear polymers of varied number-average molecular weight (M n ) from each of three different series. The three series corresponded to polymers modified with either zero, one or two tin ends per chain. In general, the relative hysteresis contributions depend on strain amplitude and M n . For unmodified polymers at strain amplitudes from 0.02 to 0.07, and with M n in the neighborhood of 150 kg/mole, each of the three hysteresis sources contributes about one-third of the total tan δ. With respect to shear loss modulus ( G ″), the carbon black network contributes about 60%, while free chain ends and the effective polymer network chains each contribute about 20%. At the same M n and strain conditions, tin end-modified polymers reduce G ″ and tan δ by as much as 60%, in comparison to their unmodified counterparts. The benefit is achieved primarily through reductions of up to 85% in the carbon black network contribution to hysteresis. Since the hysteresis contribution from free chain ends is not reduced so much by tin end-modification, the greatest potential for additional tan δ benefits lies in further free chain end reduction. In addition, it was found that tin end-modification has no measurable effect on the hysteresis contribution from effective network chains. Further, the analysis showed that an ineffective polymer network chain provides approximately ten times the hysteresis and one-half the elasticity of an effective network chain, at the test conditions of the current study. In general, the quantitative results, and some qualitative results as well, will change with compound composition and with temperature. Consequently, the development of a methodology, one that allows estimation of individual hysteresis contributions from different sources, is a major component of the present study.
Dry Vertical Alignment Method for Multi-domain Homeotropic Thin-Film-Transistor Liquid Crystal Displays (2001)

Multi-domain homeotropic liquid crystal alignment has been recognized as an alignment method to achieve wide viewing angle for thin-film-transistor liquid crystal displays (TFT-LCDs). In the past decade, several types of multi-domain homeotropic TFT-LCDs have been well studied. In all these LCDs, a homeotropic polyimide layer is used to align liquid crystal molecules. In this paper, a new homeotropic alignment method-dry deposition vertical alignment (or vacuum deposition vertical alignment) is introduced. We studied several different vacuum deposited vertical alignment materials and one of them was demonstrated on a high resolution ridge fringe-field multi-domain homeotropic (RFFMH) TFT-LCD. This new method has advantages over the conventional polyimide alignment method: it simplifies the manufacturing process by avoiding wet chemical processes and improves the viewing angle by reducing light leakage.
FACTORS CONTROLLING WETTING OF MAGNESIUM OXIDE BY SILICATE LIQUIDS (1969)

liquid interfacial energy of the magnesium oxide-monticellite (CaO .MgO. Si02) system has been studied.The thermodynru1ic equilibrium of the magnesium oxide-monticellite system is disturbed with R203 and Ti0 2 additions to the liquid.At the liquid-solid interface, reactions occur in order to achieve an equilibrium composition.The degree of wetting is directly proportional to the magnitude of (-) ~G of this interface reaction.Therefore, the reported conta'ct angles are the steady state angles of a transient reaction stage.The contact :angle of the monticellite liquid on the (100) face of ,.MgO single crystal was in the range of 43-51 at 1550 0 C.With additions of Al203 and Fe203, the angle decreased to a value of 35 and 15, respectively.Spreading was obtained with Cr203 and Ti02 additions.'" AI> ".