gebhart/patrepeval huggingface dataset:
Effects of Unilateral Prefrontal Lesions on Familiarity, Recollection, and Source Memory (2005)

Recognition memory can be supported by both the assessment of the familiarity of an item and by recollection of the context in which an item was encountered. Some have hypothesized that the prefrontal cortex (PFC) disproportionately contributes to recollection, whereas an alternative view is that the PFC contributes to both recollection and familiarity. Here, we examined the effects of prefrontal lesions on recollection and familiarity. Patients with unilateral PFC lesions and age-, gender-, and education-matched controls encoded pictures of meaningful objects that were presented briefly to the left or right visual field and subsequently performed recognition tests for centrally presented objects. Laterality effects within the PFC were also assessed in relation to recollection and familiarity processes. Patients with prefrontal lesions showed impaired familiarity-based recognition, and this deficit was specific for objects encoded by the lesioned hemisphere. In addition, recollection of the context in which each item was encountered was impaired independent of the visual field of presentation in patients with left prefrontal lesions. Recollection measured by subjective reports ("remember") was not impaired in either left or right frontal patients. These findings suggest that the PFC plays a critical role in recognition memory based on familiarity as well as recollection. Furthermore, these results suggest that left PFC regions are critical for source recollection.
Human iPSC-Derived Cardiomyocytes are Susceptible to SARS-CoV-2 Infection (2020)

Coronavirus disease 2019 (COVID-19) is a viral pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is predominantly defined by respiratory symptoms, but cardiac complications including arrhythmias, heart failure, and viral myocarditis are also prevalent. Although the systemic ischemic and inflammatory responses caused by COVID-19 can detrimentally affect cardiac function, the direct impact of SARS-CoV-2 infection on human cardiomyocytes is not well-understood. We used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as a model system to examine the mechanisms of cardiomyocyte-specific infection by SARS-CoV-2. Microscopy and immunofluorescence demonstrated that SARS-CoV-2 can enter and replicate within hiPSC-CMs, localizing at perinuclear locations within the cytoplasm. Viral cytopathic effect induced hiPSC-CM apoptosis and cessation of beating after 72 hours of infection. These studies show that SARS-CoV-2 can infect hiPSC-CMs <i>in vitro</i> , establishing a model for elucidating the mechanisms of infection and potentially a cardiac-specific antiviral drug screening platform.
The effect of interconnection resistance on the performance enhancement of liquid-nitrogen-cooled CMOS circuits (1989)

The interconnection is modeled as a distributed RLC line driven by an optimal configuration of cascaded inverters. The thin-film resistivity of pure aluminum has been measured to allow accurate prediction of the effect of interconnection resistance on performance. A critical interconnect length is defined as the point at which interconnect resistance begins to dominate propagation delay time. The critical interconnect length is computed at room temperature and liquid-nitrogen temperature for present-day and scaled CMOS technologies and compared to the maximum interconnect length expected in state-of-the-art VLSI circuits.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Electronic structure of compounds containing metal-metal bonds. Decacarbonyldimetal and related complexes (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic structure of compounds containing metal-metal bonds. Decacarbonyldimetal and related complexesRobert A. Levenson and Harry B. GrayCite this: J. Am. Chem. Soc. 1975, 97, 21, 6042–6047Publication Date (Print):October 1, 1975Publication History Published online1 May 2002Published inissue 1 October 1975https://pubs.acs.org/doi/10.1021/ja00854a015https://doi.org/10.1021/ja00854a015research-articleACS PublicationsRequest reuse permissionsArticle Views417Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Experiments on IP and physical layer packet throughput performance in evolved UTRA uplink using SC-FDMA radio access (2008)

This paper presents experimental results on the throughput performance of IP and physical layer packets in the Evolved UTRA uplink using single-carrier FDMA radio access. The IP packet performance is investigated using a base station and four sets of user equipment, in which medium access control (MAC) layer processing and key packet radio access techniques in the physical layer such as frequency domain channel-dependent scheduling, adaptive modulation and coding (AMC), and hybrid automatic repeat request (HARQ) with soft-combining are implemented. The extensive experimental results clarify the robustness and effectiveness of frequency domain channel-dependent scheduling, AMC, and HARQ in achieving high throughput of IP and physical layer packets in a multipath Rayleigh fading channel.
Determination Of Kinetic Parameters Of Combustion Processes Using Optical Detection Techniques (1981)

The increased use of dirty fuels such as coal and oil shale in station-ary combustors has increased the necessity for controlling NOx emissions. A potential method to accomplish this goal is the thermal deN0x process, where ammonia added to the combustion exhaust gas chemically converts nitric oxide to harmless products (N2 and H20). A complete understanding of the chemical processes occurring has been hampered by a lack of detailed high-temperature kinetic data. Using a high-temperature fast flow reactor equipped with a variety of optical detection devices, key rate parameters and product channels are determined for this process, and, in conjunction with computer modeling, a consistent comprehensive model is developed which describes the features of the NHi/NOx chemical system.
Randomized study of paclitaxel-cisplatin versus cisplatin-teniposide in patients with advanced non-small-cell lung cancer. The European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group. (1998)

Although survival was not improved, arm B offers a better palliation for advanced NSCLC patients than arm A.
Direct synthesis of the organic and Ge free Al containing BOG zeolite (ITQ-47) and its application for transformation of biomass derived molecules (2020)

Aluminosilicate boggsite (Si/Al-BOG) has been hydrothermally synthesized without adding organic structure-directing agents (OSDAs) in the synthesis gel using the borosilicogermanium ITQ-47 (Si/B-ITQ-47) zeolite as seeds. The introduction of the costly and environmentally less benign phosphazene organic structure-directing agent is not required to grow the zeolite. Physicochemical characterization experiments show that Si/Al-BOG has good crystallinity, high surface area, tetrahedral Al<sup>3+</sup> species, and acid sites. In order to test the catalytic performance of the zeolite, the synthesis of l,l-lactide from l-lactic acid was performed. Si/Al-BOG exhibits 88.2% conversion of l-lactic acid and 83.8% l,l-lactide selectivity, which are better than those of other zeolites studied up to now.
The autoimmunity-associated BLK haplotype exhibits cis-regulatory effects on mRNA and protein expression that are prominently observed in B cells early in development (2012)

The gene B lymphocyte kinase (BLK) is associated with rheumatoid arthritis, systemic lupus erythematosus and several other autoimmune disorders. The disease risk haplotype is known to be associated with reduced expression of BLK mRNA transcript in human B cell lines; however, little is known about cis-regulation of BLK message or protein levels in native cell types. Here, we show that in primary human B lymphocytes, cis-regulatory effects of disease-associated single nucleotide polymorphisms in BLK are restricted to naïve and transitional B cells. Cis-regulatory effects are not observed in adult B cells in later stages of differentiation. Allelic expression bias was also identified in primary human T cells from adult peripheral and umbilical cord blood (UCB), thymus and tonsil, although mRNA levels were reduced compared with B cells. Allelic regulation of Blk expression at the protein level was confirmed in UCB B cell subsets by intracellular staining and flow cytometry. Blk protein expression in CD4(+) and CD8(+) T cells was documented by western blot analysis; however, differences in protein expression levels by BLK genotype were not observed in any T cell subset. Blk allele expression differences at the protein level are thus restricted to early B cells, indicating that the involvement of Blk in the risk for autoimmune disease likely acts during the very early stages of B cell development.
Molecular Genetic Analysis Reveals Chromosomal Deletion, Gene Amplification, and Autocrine Growth Factor Production in the Pathogenesis of Human Lung Cancer (1986)

These studies of lung cancer suggest that a number of molecular mechanisms may be important in the pathogenesis of lung cancer, especially SCLC. An inherited predisposition to develop SCLC may correlate with a nonfunctional, recessive allele for a gene (McKusick #18228, McKusick 1986) that maps to chromosome region 3p(14-23). Individuals at risk would be heterozygous for this allele in their germ line, carrying one copy of a normal functional gene and one mutant, recessive allele. Exposure to carcinogens, in particular cigarette smoke, can produce somatic genetic changes such as chromosomal deletion or gene mutation in the functional allele of this gene, unmasking the nonfunctional allele. Loss of this normal gene may alter the regulation of cell growth, perhaps by allowing the deregulated expression of proto-oncogenes of the myc family, or autocrine growth factors such as GRP and/or its receptor. Alternatively, loss of this gene may result in the cell returning to a less differentiated developmental state where growth regulation is less stringent. Persons with this mutant gene should be at increased risk to develop SCLC, and further RFLP analysis of the 3p region in SCLC may allow identification of specific haplotypes with increased risk of developing lung cancer. If this notion is correct, one might expect to find an increased frequency of second tumors in lung cancer patients and the presence of similar chromosomal deletions in second tumors arising in SCLC patients. In this regard, cured lung cancer patients, including those with SCLC, have a tenfold increased risk of developing a second lung cancer (Fontana 1977; Cortese et al. 1983; Johnson et al. 1986b). In fact, a chromosome 3p deletion along with other chromosomal abnormalities was identified in acute erythroleukemia cells arising in a long-term survivor of SCLC (Bradley et al. 1982), implicating this same region in the pathogenesis of both tumors. Other predictions include the correction of at least a portion of the defect by introducing a normal chromosome 3 into SCLC cells. While c-myc is expressed in many fetal and adult tissues, high-level expression of N- and L-myc is very restricted as to tissue and stage in the developing mouse, with N-myc expressed in the fetal but not adult lung, whereas the lung was the only adult tissue where L-myc expression was detected (Zimmerman et al. 1986). Could these patterns provide a clue to the differential expression of c-, N-, and L-myc found in different lung cancers (Nau et al. 1986)?(ABSTRACT TRUNCATED AT 400 WORDS)
Nanostructured Carbon and Polymer Materials‐ Synthesis and their Application in Energy Conversion Devices (2012)

This chapter contains sections titled: Introduction Inorganic and Organic Semiconductors for Solar Cell Materials for Organic Solar Cell: Donor Materials for Organic Solar Cell: Acceptor Our Efforts Towards Material Synthesis for OPV Conclusions Acknowledgements
Emerging connections between gut microbiome bioenergetics and chronic metabolic diseases (2021)

The conventional viewpoint of single-celled microbial metabolism fails to adequately depict energy flow at the systems level in host-adapted microbial communities. Emerging paradigms instead support that distinct microbiomes develop interconnected and interdependent electron transport chains that rely on cooperative production and sharing of bioenergetic machinery (i.e., directly involved in generating ATP) in the extracellular space. These communal resources represent an important subset of the microbial metabolome, designated here as the "pantryome" (i.e., pantry or external storage compartment), that critically supports microbiome function and can exert multifunctional effects on host physiology. We review these interactions as they relate to human health by detailing the genomic-based sharing potential of gut-derived bacterial and archaeal reference strains. Aromatic amino acids, metabolic cofactors (B vitamins), menaquinones (vitamin K2), hemes, and short-chain fatty acids (with specific emphasis on acetate as a central regulator of symbiosis) are discussed in depth regarding their role in microbiome-related metabolic diseases.
The Sonochemical Insertion of Nanomaterials into Mesostructures (2004)

Ultrasound radiation has been recently used for the synthesis of mesoporous materials (MSPM). The main advantages are manifested in the short preparation time and thicker walls leading to a more hydrothermally stable structure.1 This preparation method has already been reviewed.2 The discovery of MSP materials led immediately to the development of many experimental methods for the deposition of materials, especially catalytic materials, into the mesopores. Impregnation, thermal spreading, ion adsorption, and the most recent method3 in which colloidal gold solution is premixed with the precursors for the preparation of the MSPM, are among the methods used for the insertion of materials into the mesopores. Sonochemistry was also employed for this purpose. We will outline in this article the use of the sonochemical processes for the insertion of nanomaterials into the pores of MSPM. We will explain how this process is conducted, to what extent the materials are deposited in the pores and what is the mechanism for the insertion. An example will be given for the preparation of Ru/MSP TiO2 and its application as a catalyst in the wet air oxidation of succinic acid and acetic acid, which often appear as the ultimate intermediates in oxidation of many organic pollutants.
Ulerythema Ophryogenes and Keratosis Pilaris in a Child with Monosomy 18p (1994)

We report a 13-year-old boy with deletion of the short arm of chromosome 18 and follicular, partially inflammatory, keratotic papules of the eyebrows, foreskin, and cheeks (ulerythema ophryogenes) as well as the shoulders, upper back, upper arms, and thighs (keratosis pilaris), initially diagnosed as atopic dermatitis. Over 100 patients with this genetic defect have been reported, and the 18p- syndrome is considered one of the most frequently occurring deletion syndromes. However, ulerythema ophryogenes and keratosis pilaris have not been described in any of these patients, although the association of the latter with other genetic abnormalities is well known. Keratosis pilaris is a relatively common genodermatosis of ectodermal origin, frequently occurring with ichthyosis or atopy; concomitance with ulerythema ophryogenes has also been reported. The association of chromosome 18p deletion defect and ulerythema ophryogenes may be helpful in future attempts to localize the gene defect responsible for follicular genokeratoses.
Effects of Leonurus japonicus Houtt. and its N-containing constituents leonurine and stachydrine on the activity of PPARα, β/δ, and γ in a newly developed in vitro luciferase reporter gene assay (2014)

Leonurus japonicus (Yimucao; Chin.Ph., DAB) has been used in TCM since earliest times [1] for conditions presently referred to as the “metabolic syndrome”. Here, the agonistic activity of aqueous Yimucao extracts – both from China and from German TCM plant cultivation – and their dominant constituents leonurine and stachydrine [2, 3] on the metabolic syndrome related peroxisome proliferator-activated receptors (PPAR) α, β/δ, and γ was investigated using a novel luciferase reporter gene assay [4]. COS-1 cells were co-transfected with the luciferase reporter plasmid p17m2G, containing a GAL4 upstream activating sequence in the promoter region, an expression vector for the human PPARβ/δ ligand-binding domain fused to the GAL4 DNA-binding domain pPPARβ/δ-GAL4, and the secreted alkaline phosphatase control vector pSEAP. The results are relative to the luciferase expression levels, which were normalized using secreted alkaline phosphatase (SEAP) activity. The two L. japonicus extracts and the two isolated constituents (all at 6.25, 25, and 100 µg/ml), and GW0742 (positive control, 0.1 nM) were dissolved in DMSO and added to the medium of the transfected cells. The same approach was used for PPARα and PPARγ in which case the COS-1 cells were transfected with pPPARα or γ-GAL4 and p17m2G, respectively (positive controls 50µM WY14643/10µM troglitazone). Whereas significant activity was measured for the Chinese Yimucao extract in all three PPAR assays at both 100 and to a lesser extent 25 µg/ml, no activity above DMSO vehicle negative control levels could be detected for the sample from German cultivation or for the two N-containing compounds. Thus, the agonistic activity of Chinese Yimucao in all three PPARs indicates its potential for diabetes and metabolic syndrome therapy. However, the still unidentified active constituents seem to be absent from the German cultivated drug.
Biochemical Features and Functional Implications of the RNA-Based T-Box Regulatory Mechanism (2009)

The T-box mechanism is a common regulatory strategy used for modulating the expression of genes of amino acid metabolism-related operons in gram-positive bacteria, especially members of the Firmicutes. T-box regulation is usually based on a transcription attenuation mechanism in which an interaction between a specific uncharged tRNA and the 5' region of the transcript stabilizes an antiterminator structure in preference to a terminator structure, thereby preventing transcription termination. Although single T-box regulatory elements are common, double or triple T-box arrangements are also observed, expanding the regulatory range of these elements. In the present study, we predict the functional implications of T-box regulation in genes encoding aminoacyl-tRNA synthetases, proteins of amino acid biosynthetic pathways, transporters, and regulatory proteins. We also consider the global impact of the use of this regulatory mechanism on cell physiology. Novel biochemical relationships between regulated genes and their corresponding metabolic pathways were revealed. Some of the genes identified, such as the quorum-sensing gene luxS, in members of the Lactobacillaceae were not previously predicted to be regulated by the T-box mechanism. Our analyses also predict an imbalance in tRNA sensing during the regulation of operons containing multiple aminoacyl-tRNA synthetase genes or biosynthetic genes involved in pathways common to more than one amino acid. Based on the distribution of T-box regulatory elements, we propose that this regulatory mechanism originated in a common ancestor of members of the Firmicutes, Chloroflexi, Deinococcus-Thermus group, and Actinobacteria and was transferred into the Deltaproteobacteria by horizontal gene transfer.
Heat-Shielding Nanobrick Wall for Carbon Fiber-Reinforced Polymer Composites (2023)

Owing to their excellent mechanical properties, carbon fiber-reinforced polymer (CFRP) composites have a broad spectrum of applications in aerospace, civil engineering, automotive, and numerous industrial fields. Despite their many advantages, the inherent lack of thermal stability of the polymer matrix results in the loss of the composite’s mechanical properties when exposed to elevated temperatures. In an effort to provide thermal protection, a multilayer film composed of tris(hydroxymethyl)-aminomethane (THAM)-buffered polyethylenimine (PEI) and vermiculite (VMT) clay was deposited on CFRP composites via layer-by-layer assembly. When subjected to the flame from a butane torch and mechanical loading, the polymer–clay nanobrick wall provides substantial thermal insulation, decreasing the temperature on the backside of the CFRP composites by as much as 100 °C. The PEI-THAM/VMT coating also helps to maintain the storage modulus of the composite and offers significant protection from oxidative degradation, as confirmed by dynamic mechanical analysis and X-ray photoelectron spectroscopy. The performance of this polymer–clay multilayer film provides excellent thermal barrier that can be used to protect advanced composite materials from extreme heat.