gebhart/patrepeval huggingface dataset:
pO2-weighted imaging in vivo by delayed fluorescence of intracellular Protoporphyrin IX (2020)

In this Letter, we report on the imaging of tissue oxygen by means of time-gated wide-field lifetime imaging of the microsecond-scale delayed fluorescence from Protoporphyrin IX (PpIX). PpIX is produced endogenously from a clinically used <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mi>δ</mml:mi> </mml:math> -aminolevulinic acid (5-ALA) by most cells. The lifetime of delayed fluorescence is lengthened by the absence of oxygen to quench its triplet state. Here, the images of the delayed emission from the human skin and the skin of nude mice were captured after topical application of 5-ALA, using a pulsed 635 nm excitation. Macroscopic lifetime-based images were found to be associated with the tissue oxygenation and obtained with a low light dose ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mo>∼</mml:mo> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mn>10</mml:mn> </mml:mrow> <mml:mspace width="thickmathspace"/> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msup> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi mathvariant="normal">m</mml:mi> <mml:mi mathvariant="normal">J</mml:mi> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mo>/</mml:mo> </mml:mrow> <mml:mi mathvariant="normal">c</mml:mi> <mml:mi mathvariant="normal">m</mml:mi> </mml:mrow> <mml:mn>2</mml:mn> </mml:msup> </mml:mrow> </mml:math> ) and “capture-times” of a few seconds.
A study of seroprevalence of HIV-1 and HIV-2 in six provinces of People's Republic of Angola: clues to the spread of HIV infection. (1990)

A seroepidemiological study was carried out to determine the distribution of the human immunodeficiency viruses type 1 (HIV-1) and type 2 (HIV-2) in the People's Republic of Angola, where HIV-2 existence was previously unknown and HIV-1 seropositivity was only reported to be present in Luanda and Cabinda. A total of 1,695 serum samples were obtained from healthy persons (control group) and from a group of patients in the provinces of Zaire (13), Lunda-Norte (L.N.) (749), Luanda (556), Huambo (154), Kuando-Kubango (K.-K.) (49), and Namibe (119). All samples were tested for HIV-1 and HIV-2 antibodies by enzyme-linked immunosorbent assay and an indirect immunofluorescence assay using MOLT-T4 cells. Positive samples were confirmed by the Western-blot technique. Sera giving cross reactivity at the level of HIV-1 and HIV-2 large glycoproteins were further tested by radioimmunoprecipitation assay and by reactivity against a peptide corresponding to the dominant epitope of the transmembrane protein. The overall seroprevalance was 14.2%, with significantly higher values in the patient group [19.4% (HIV-1 = 8.8%; HIV-2 = 8.4%; HIV-1 + HIV-2 = 2.2%)] than the control group [9.3% (HIV-1 = 3.3%; HIV-2 = 5.3%; HIV-1 + HIV-2 = 0.7%)]. HIV-2 as well as HIV-1 infection is actually present in Angola in all studied provinces. Higher seroprevalence was seen in the provinces of Zaire, Lunda Norte, and Huambo. People displacements, mainly as a consequence of the war, certainly play an important role in spreading HIV infection from the northern frontier areas of the country to the central and southern regions.
Synthesis of hexaazacryptands containing furan and benzene groups in the bridging arms (1998)

Abstract Two new hexaazacryptands were prepared. One contains two propylene groups and a 2,5‐furandimethylene unit between the nitrogen atoms of each bridge. The other has two propylene groups and a p ‐phenylene unit between the nitrogen atoms of each bridge.
Comparison of Leakage Performance in Three Types of Gas Annular Seals Operating at a High Temperature (300°C) (2010)

Adequate sealing in rotating machinery reduces secondary leakage and results in more efficient and stable systems. Labyrinth seals are most common, although brush seals are popular in specialized applications. The hybrid brush seal (HBS) is a novel design that adds to the bristle brush matrix a number of cantilever pads that rest on the rotor surface. Upon shaft rotation the pads lift due to the generation of a hydrodynamic gas film, and the brushes effectively seal an upstream pressure. Hence, the HBS has no wear and no local thermal distortion effects. This article presents measurements of leakage versus pressure differential obtained in a three-tooth labyrinth, a conventional brush seal, and a hybrid brush seal for operation at high temperature (300°C) and with shaft surface speeds to 26 m/s. The measurements demonstrate that the HBS leaks ∼ 31% less than a standard brush seal and is significantly better (∼ 68%) than a similarly sized labyrinth seal. As temperature increases, the labyrinth seal leakage decreases because its clearance changes due to the thermal growth of the components. The HBS, on the other hand, shows leakage that is nearly insensitive to air inlet temperature. The measurements demonstrate HBS as a reliable seal technology for use in gas turbines, for example.
Competition Between Raman and Kerr Effects in Microresonators (2017)

We investigate competing effects of Raman and Kerr gain in diamond microresonators. Strong, narrowband Raman gain inherent in crystalline materials determines a maximum microresonator size allowable to achieve Kerr combs.
Machine learning-based classification of Alzheimer’s disease and its at-risk states using personality traits, anxiety, and depression (2022)

Abstract Background Alzheimer’s disease (AD) is often preceded by stages of cognitive impairment, namely subjective cognitive decline (SCD) and mild cognitive impairment (MCI). While cerebrospinal fluid (CSF) biomarkers are established predictors of AD, other non-invasive candidate predictors include personality traits, anxiety, and depression, among others. These predictors offer non-invasive assessment and exhibit changes during AD development and preclinical stages. Methods In a cross-sectional design, we comparatively evaluated the predictive value of personality traits (Big Five), geriatric anxiety and depression scores, resting-state functional magnetic resonance imaging activity of the default mode network, apoliprotein E (ApoE) genotype, and CSF biomarkers (tTau, pTau181, Aβ42/40 ratio) in a multi-class support vector machine classification. Participants included 189 healthy controls (HC), 338 individuals with SCD, 132 with amnestic MCI, and 74 with mild AD from the multicenter DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE). Results Mean predictive accuracy across all participant groups was highest when utilizing a combination of personality, depression, and anxiety scores. HC were best predicted by a feature set comprised of depression and anxiety scores and participants with AD were best predicted by a feature set containing CSF biomarkers. Classification of participants with SCD or aMCI was near chance level for all assessed feature sets. Conclusion Our results demonstrate predictive value of personality trait and state scores for AD. Importantly, CSF biomarkers, personality, depression, anxiety, and ApoE genotype show complementary value for classification of AD and its at-risk stages. Key Points - Multi-class support vector machine classification was used to compare the predictive value of well-established and non-invasive, easy-to-assess candidate variables for classifying participants with healthy cognition, subjective cognitive decline, amnestic mild cognitive impairment, and mild Alzheimer’s disease. - Personality traits, geriatric anxiety and depression scores, resting-state functional magnetic resonance imaging activity of the default mode network, ApoE genotype, and CSF biomarkers were comparatively evaluated. - A combination of personality, anxiety, and depression scores provided the highest predictive accuracy, comparable to CSF biomarkers, indicating complementary value. - Established and candidate predictors had limited success in classifying SCD and aMCI, underscoring the heterogeneity of these cognitive states and emphasizing the need for standardizing terminology and diagnostic criteria.
Hybrid Lattice Reduction Algorithm And Its Implementation On An Sdr Baseband Processor For Lte (2011)

Publication in the conference proceedings of EUSIPCO, Barcelona, Spain, 2011
Investigation of the electrical activity of partial dislocations in SiC p-i-n diodes (2005)

The electron-beam-induced current (EBIC) mode of scanning electron microscopy was employed to investigate the nucleation and development of stacking faults (SFs) during forward high current stress operation of 4H–SiC p-i-n diodes. The EBIC technique is shown to be a valuable tool for the visualization and analysis of mobile and immobile partial dislocations bounding the SFs and their recombination activity. Both Si and C core partial dislocations exhibit similar EBIC contrast. It is shown that threading edge dislocations can be one source of SF generation leading to the degradation of p-i-n diodes.
13C CPMAS NMR spectroscopy as a probe for porphyrin–porphyrin and host–guest interactions in the solid state (1998)

Solid-state 13C cross-polarisation magic-angle spinning (CPMAS) NMR spectra of a range of metalloporphyrin monomers, dimers, trimers and various host–guest adducts have been obtained. Interpretation of these spectra provides information on crystal packing (molecular stacking) and host–guest interactions in the solid state. X-Ray structures are reported for a para- and meta-substituted zinc porphyrin monomer. Comparison of the CPMAS data with the X-ray data of these selected monomers provides convincing evidence for the crystal packing assignment based on both solid state techniques.
Photochemistry of 2-phenylbenzothiazole with ethoxyacetylene and ethoxypropyne. Synthesis of 1,5-benzothiazepines (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemistry of 2-phenylbenzothiazole with ethoxyacetylene and ethoxypropyne. Synthesis of 1,5-benzothiazepinesM. Sindler-Kulyk and D. C. NeckersCite this: J. Org. Chem. 1982, 47, 25, 4914–4919Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/jo00146a018https://doi.org/10.1021/jo00146a018research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The sonochemical synthesis and characterization of Cu1−xNixWO4nanoparticles/nanorods and their application in electrocatalytic hydrogen evolution (2009)

Cu(1-x)Ni(x)WO(4) (x = 0.0, 0.2, 0.4, 0.6, 0.8, and 1.0) nanoparticles/nanorods have been prepared by a novel sonochemical method using cetyltrimethylammonium bromide (CTAB) as the structure directing agent. The prepared materials have been characterized by thermogravimetric analysis (TGA), x-ray diffraction (XRD), Raman spectroscopy, transmission electron microscopy (TEM), and BET specific surface area. The electrocatalytic activity towards the hydrogen evolution reaction (HER) has been studied for the Ni(2+)-substituted CuWO(4) nanoparticles by using linear sweep voltammogram measurements in a 1 M H(2)SO(4) solution. Cu(0.4)Ni(0.6)WO(4) (-473 mA cm(-2) at -1 V) shows a better catalytic activity than native CuWO(4) (-300 mA cm(-2) at -1 V).
Fragmentation of organic ions bearing fixed multiple charges observed in MALDI MS (2017)

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI TOF MS) was used to analyze a series of synthetic organic ions bearing fixed multiple charges. Despite the multiple intrinsic charges, only singly charged ions were recorded in each case. In addition to the pseudo-molecular ions formed by counterion adduction, deprotonation and electron capture, a number of fragment ions were also observed. Charge splitting by fragmentation was found to be a viable route for charge reduction leading to the formation of the observed singly charged fragment ions. Unlike multivalent metal ions, organic ions can rearrange and/or fragment during charge reduction. This fragmentation process will evidently complicate the interpretation of the MALDI MS spectrum. Because MALDI MS is usually considered as a soft ionization technique, the fragment ion peaks can easily be erroneously interpreted as impurities. Therefore, the awareness and understanding of the underlying MALDI-induced fragmentation pathways is essential for a proper interpretation of the corresponding mass spectra. Due to the fragment ions generated during charge reduction, special care should be taken in the MALDI MS analysis of multiply charged ions. In this work, the possible mechanisms by which the organic ions bearing fixed multiple charges fragment are investigated. With an improved understanding of the fragmentation mechanisms, MALDI TOF MS should still be a useful technique for the characterization of organic ions with fixed multiple charges.
Design of Enhanced MT-RJ Type Connector for Physical Contact (2004)

An enhanced MT-RJ type connector was constructed employing a compact two-fiber ferrule in a newly designed housing for high-density optical duplex connection. The ferrule and the connector housing is designed to achieve physical contact (PC). As a result, the connectors we fabricated perform very well and provide ease of operation by means of direct core endface contact between the plugs. This connector is highly effective for use in the duplex connection of advanced optical networks.
Reconfigurable Nanopolygons Made of DNA Catenanes (2023)

The development of new types of bonds and linkages that can reversibly tune the geometry and structural features of molecules is an elusive goal in chemistry. Herein, we report the use of catenated DNA structures as nanolinkages that can reversibly switch their angle and form different kinds of polygonal nanostructures. We designed a reconfigurable catenane that can self-assemble into a triangular or hexagonal structure upon addition of programmable DNA strands that function via toehold strand-displacement. The nanomechanical and structural features of these catenated nanojoints can be applied for the construction of dynamic systems such as molecular motors with switchable functionalities.
Cell‐Cycle‐Dependent Active Thermal Bystander Effect (ATBE) (2011)

These results suggest that the ATBE is a cell-cycle-dependent process which requires actively dividing cells as receiving bystander cells. The cell-cycle dependency of the ATBE could have useful clinical applications in selectively targeting fast growing cells such as tumor cells. Whether the yield of the ATBE can be amplified by synchronizing the exposure to the ATBE with specific phases of the cell cycle remains subject to further investigation.
Rheological investigation of interactions between sorbitol and polyhedral oligomeric silsesquioxane in development of nanocomposites of isotactic polypropylene (2010)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Jairo E. Perilla, Byoung-Jo Lee, Sadhan C. Jana; Rheological investigation of interactions between sorbitol and polyhedral oligomeric silsesquioxane in development of nanocomposites of isotactic polypropylene. J. Rheol. 1 July 2010; 54 (4): 761–779. https://doi.org/10.1122/1.3439695 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search
The neutralization potency of anti-SARS-CoV-2 therapeutic human monoclonal antibodies is retained against viral variants (2021)

A wide range of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing monoclonal antibodies (mAbs) have been reported, most of which target the spike glycoprotein. Therapeutic implementation of these antibodies has been challenged by emerging SARS-CoV-2 variants harboring mutated spike versions. Consequently, re-assessment of previously identified mAbs is of high priority. Four previously selected mAbs targeting non-overlapping epitopes are now evaluated for binding potency to mutated RBD versions, reported to mediate escape from antibody neutralization. In vitro neutralization potencies of these mAbs, and two NTD-specific mAbs, are evaluated against two frequent SARS-CoV-2 variants of concern, the B.1.1.7 Alpha and the B.1.351 Beta. Furthermore, we demonstrate therapeutic potential of three selected mAbs by treatment of K18-human angiotensin-converting enzyme 2 (hACE2) transgenic mice 2 days post-infection with each virus variant. Thus, despite the accumulation of spike mutations, the highly potent MD65 and BL6 mAbs retain their ability to bind the prevalent viral mutants, effectively protecting against B.1.1.7 and B.1.351 variants.
Emmett Leith and the Solidification of a Communications Viewpoint in Optics (2006)

The invention of the “carrier frequency” hologram by Emmett Leith and his colleagues energized a remarkable influx of communications ideas into optics, and helped solidify the role of optics in electrical engineering.
Thermal Management of Vertically Integrated Packages (2008)

This chapter contains sections titled: Introduction Fundamentals of Heat Transfer Thermal-Packaging Modeling Metrology in Thermal Packaging Thermal Packaging Components Heat Removal in Vertically-Integrated Packages References
Glucose metabolism and rate constants in Alzheimer's disease examined with dynamic positron emission tomography scan (1989)

Glucose metabolic rate constants in patients with Alzheimer's disease were analyzed using dynamic positron emission tomography with [18-F] fluoro-2-deoxyglucose (FDG). The cerebral metabolic rate of glucose (CMRG) was calculated using obtained rate constants, as well as the autoradiographic method. The half-life and distribution volume of FDG between the blood and the brain tissue were also calculated from obtained metabolic rate constants. The most severely affected metabolic step was the phosphorylation of glucose in the parietotemporal regions. The distribution volume of FDG showed no remarkable deviation from normal controls, while the half-life of FDG was found to be longer in the parietal and temporal regions. The CMRG from rate constants and that from the autoradiographic method showed no remarkable differences.
Advanced motion control in redundant motion systems (2002)

As each joint actuator of a robot manipulator has a limited value of torque, the motion control system should consider the torque saturation. This paper proposes the new autonomous consideration method of joint torque saturation for robust redundant manipulator motion control. The proposed method consists of a torque limitation algorithm in the joint space, an adjustment algorithm of the motion control in Cartesian space, and an adjustment algorithm of the motion reference in Cartesian space. The redundant manipulator motion control using the proposed algorithms well realizes the smooth and robust motion response.
Connectionist generalization for production: an example from GridFont (2002)

The authors designed and trained a connectionist network so that it could generate letterforms in a new font given just a few exemplars from that font. During learning, the network constructed a distributed internal representation of different fonts and letters, even though each training instance had both font characteristics and letter characteristics. For successful generation of letterforms, it was found that it was necessary to have separate but interconnected hidden units for 'letter' and 'font' representations. The limitations of the network can be attributed, in part, to limited training data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Enhanced T cell recovery in HIV-1–infected adults through IL-7 treatment (2009)

HIV infection results in CD4+ T cell deficiency, but efficient combination antiretroviral therapy (c-ART) restores T cells and decreases morbidity and mortality. However, immune restoration by c-ART remains variable, and prolonged T cell deficiency remains in a substantial proportion of patients. In a prospective open-label phase I/IIa trial, we evaluated the safety and efficacy of administration of the T cell regulator IL-7. The trial included 13 c-ART-treated HIV-infected patients whose CD4+ cell counts were between 100 and 400 cells/microl and plasma HIV RNA levels were less than 50 copies/ml. Patients received a total of 8 subcutaneous injections of 2 different doses of recombinant human IL-7 (rhIL-7; 3 or 10 microg/kg) 3 times per week over a 16-day period. rhIL-7 was well tolerated and induced a sustained increase of naive and central memory CD4+ and CD8+ T cells. In the highest dose group, 4 patients experienced transient increases in viral replication. However, functional assays showed that the expanded T cells responded to HIV antigen by producing IFN-gamma and/or IL-2. In conclusion, in lymphopenic HIV-infected patients, rhIL-7 therapy induced substantial functional and quantitative changes in T cells for 48 weeks. Therefore, patients may benefit from intermittent therapy with IL-7 in combination with c-ART.