gebhart/patrepeval huggingface dataset:
Abstract 3680: The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane (2010)

Abstract Persistently activated hyper-phosphorylated Akt contributes to human oncogenesis and tumor resistance. TCN-P, the active metabolite of the Akt phosphorylation inhibitor triciribine (TCN), is in clinical trials in patients whose tumors contain hyper-phosphorylated Akt, but the mechanism by which TCN-P, inhibits Akt phosphorylation is not known. In this manuscript, we show that in vitro, TCN-P inhibits neither Akt kinase activity nor the phosphorylation of Akt S473 and T308 by mTOR or PDK1, respectively. However, in intact cells, immunofluorescence and subcellular fractionation experiments demonstrate that TCN inhibits EGF-stimulated Akt recruitment to the plasma membrane and subsequent phosphorylation of Akt on Ser473 and Thr308. Surface plasmon resonance (SPR) demonstrates that TCN-P, but not TCN, binds to full-length, non-phosphorylated (inactive) Akt. However, neither TCN-P nor TCN interacts with full-length, phosphorylated (active) Akt. Furthermore, TCN-P, but not TCN, binds Akt-derived pleckstrin homology (PH) domain with KD values of 690 nM and 1.4 µM as demonstrated by SPR and isothermal calorimetry (ITC), respectively. Consistent with these data, nuclear magnetic resonance (NMR) spectroscopy shows that TCN-P, but not TCN, binds to the PH domain engaging amino acid residues in the vicinity of the PIP3 binding pocket. Thus, SPR, NMR, as well as biochemical studies indicate that the anti-cancer drug TCN-P inhibits Akt function by binding to the PH domain of Akt, blocking its recruitment to the plasma membrane and subsequent phosphorylation, suggesting that this drug may be beneficial to patients whose tumors express persistently activated Akt. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3680.
Phenytoin induced gingival overgrowth in institutionalized epileptics (1984)

In a cross-sectional, epidemiological study of phenytoin induced gingival overgrowth in 77 institutionalized persons with epilepsy, the severity of the gum lesions was quantified by means of a precise new technique. Lesion severity was then compared statistically to other clinical and laboratory parameters. Positive correlations were detected between overgrowth severity and gingival inflammation, probing depths, calculus accumulation, plaque score and the measurement gingival margin to mucogingival junction (GM-MGJ). No correlation was observed between lesion severity and patients age, daily drug dosage, plasma or saliva phenytoin level, or salivary concentration of the major phenytoin metabolite.
Ultrasound-assisted treatment of sternocutaneous fistula in post-sternotomy cardiac surgery patients (2015)

Ultrasonic debridement is a promising adjunct to SCF treatment. In combination with adequate surgical and antimicrobial therapy, we documented good mid-term results in our trial group.
Optimal Fractional Frequency Reuse (FFR) and resource allocation in multiuser OFDMA system (2009)

In this paper we determine the optimal fractional frequency reuse (FFR) and resource allocation in OFDMA system. Since the users at the cell edge are more exposed to inter-cell interference therefore each cell is partitioned into two regions; inner region and outer region. We determine the optimal FFR factor for the outer region, bandwidth assigned to each region and subcarrier and power allocation to all the users in the cell. The problem is formulated as sum-power minimization problem subject to minimum rate constraints in both the regions. This is a mixed linear integer programming problem which is relaxed into a convex optimization problem. We develop an efficient algorithm by using Lagrange dual decomposition theory at reasonable computational cost.
Transfection of TCR alpha-chains into suppressor and T helper cell hybridomas. Production of suppressor factors with predicted antigen specificity. (1995)

Conditioned medium from Ag-specific suppressor T cell hybridomas contains soluble factors (TsF) that modulate immune responses in an Ag-specific manner. We previously generated a series of TCR-alpha- and TCR-beta- expression variants from a 4-hydroxy-3-nitrophenyl acetyl (NP)-specific inducer suppressor T cell hybridoma and demonstrated that loss of TCR alpha-chain mRNA, but not TCR-beta chain mRNA, was accompanied by concomitant loss of suppressor bioactivity. Suppressor factor bioactivity was restored by expression of TCR alpha-chain cDNA, suggesting that the TCR alpha-chain plays a critical role in Ag-specific suppressor cell function. We have now transfected TCR alpha-chain from a Th cell clone specific for arsanylated peptides plus I-Ad into a TCR-alpha- derivative of an NP-specific inducer suppressor T cell hybridoma. The transfectants expressed a new hybrid TCR-alpha beta complex and produced soluble factors that suppressed azobenzenearsonate hapten (ABA) but not NP delayed-type hypersensitivity responses. These supernatants mediated suppression of the induction, but not the effector phase of the delayed-type hypersensitivity reaction. In reciprocal experiments we transfected a TCR alpha-chain from an NP-specific suppressor T cell hybridoma into a TCR-alpha- hybridoma derived from the ABA-specific Th cell hybridoma. The NP-specific TCR alpha-chain was expressed in the Th cell hybridoma, but the supernatant from this transfectant did not suppress DTH responses to either NP or ABA. However, the latter supernatants, when combined with cell lysates derived from a TCR-alpha- Ts hybridoma, specifically suppress NP DTH responses. These data are consistent with the interpretation that TCR alpha-chain imparts Ag specificity to the suppressor molecule and a second, yet undefined, component produced by the Ts hybridoma controls the immunoregulatory bioactivity.
New Horizons in Zeolites and Zeolite-Like Materials (2020)

Zeolites have been known for about 250 years, though their active life in science and industry started in the late 1960s. [...]
Increases in HIV Incidence Following Receptive Anal Intercourse Among Women: A Systematic Review and Meta-analysis (2019)

Receptive anal intercourse (RAI) carries a greater per-act risk of HIV acquisition than receptive vaginal intercourse (RVI) and may influence HIV epidemics driven by heterosexual sex. This systematic review explores the association between RAI and incident HIV among women, globally. We searched Embase and Medline through September 2018 for longitudinal studies reporting crude (cRR) or adjusted (aRR) relative risks of HIV acquisition by RAI practice among women. Of 27,563 articles identified, 17 eligible studies were included. We pooled independent study estimates using random-effects models. Women reporting RAI were more likely to acquire HIV than women not reporting RAI (pooled cRR = 1.56 95% CI 1.03-2.38, N = 18, I<sup>2</sup> = 72%; pooled aRR = 2.23, 1.01-4.92, N = 5, I<sup>2</sup> = 70%). In subgroup analyses the association was lower for women in Africa (pooled cRR = 1.16, N = 13, I<sup>2</sup> = 21%) than outside Africa (pooled cRR = 4.10, N = 5, I<sup>2</sup> = 79%) and for high-risk (pooled aRR = 1.69, N = 4, I<sup>2</sup> = 63%) than general-risk women (pooled aRR = 8.50, N = 1). Interview method slightly influenced cRR estimates (p value = 0.04). In leave-one-out sensitivity analyses pooled estimates were generally robust to removing individual study estimates. Main limitations included poor exposure definition, incomplete adjustment for confounders, particularly condom use, and use of non-confidential interview methods. More and better data are needed to explain differences in risk by world region and risk population. Women require better counselling and greater choice in prevention modalities that are effective during RVI and RAI.
Internet Gaming Disorder in Children and Adolescents (2017)

The American Psychiatric Association recently included Internet gaming disorder (IGD) as a potential diagnosis, recommending that further study be conducted to help illuminate it more clearly. This paper is a summary of the review undertaken by the IGD Working Group as part of the 2015 National Academy of Sciences Sackler Colloquium on Digital Media and Developing Minds. By using measures based on or similar to the IGD definition, we found that prevalence rates range between ∼1% and 9%, depending on age, country, and other sample characteristics. The etiology of IGD is not well-understood at this time, although it appears that impulsiveness and high amounts of time gaming may be risk factors. Estimates for the length of time the disorder can last vary widely, but it is unclear why. Although the authors of several studies have demonstrated that IGD can be treated, no randomized controlled trials have yet been published, making any definitive statements about treatment impossible. IGD does, therefore, appear to be an area in which additional research is clearly needed. We discuss several of the critical questions that future research should address and provide recommendations for clinicians, policy makers, and educators on the basis of what we know at this time.
K-domain Linearization Using Fiber Bragg Grating Array Based on Fourier Domain Optical Coherence Tomography (2011)

반도체 광 증폭기와 파브리-페롯 가변 필터를 이용한 파장 훑음 레이저 기반 광 결맞음 단층 촬영을 구성하고, 이로부터 선명한 이미징을 얻기 위한 파수 영역 선형화를 구현하였다. 파수 영역 선형화는 5 개의 서로다른 공진 파장을 가진 광섬유 격자로 이루어진 어레이를 이용하여 보간법으로 수행하였다. 샘플단의 1 mm 깊이에서 파수 영역 선형화를 수행한 후 점 분포 함수(point spread function)로부터 측정한 SNR(signal-to-noise ratio)은 12 dB 향상된 값을 얻어냈다. 또한 파수 영역 선형화 전과 후에 대해 슬라이드 글라스를 이용하여 OCT 이미징을 얻어낸 결과 파수 영역 선형화가 매우 잘 되었음을 확인할 수 있었다. We demonstrate a k-domain linearization using a fiber Bragg grating (FBG) array for Fourier domain optical coherence tomography based on a wavelength swept laser. The k-domain linearization is carried out with an interpolation method using a FBG array with five FBGs. The measured signal-to-noise ratio from the point spread function after k-domain linearization is 12 dB improved over that of without k-domain linearization at the 1 mm depth of the sample. Clear OCT imaging of the slide glass with k-domain linearization could be obtained.
Expression of Tumor Necrosis Factor α Converting Enzyme in Endocrine Cancers (2008)

Tumor necrosis factor alpha converting enzyme (TACE) mediates shedding of human epidermal growth factor receptor-4 (HER4). Recent data suggest that released HER4 intracellular domain (4ICD) induces apoptosis in breast cancer. TACE expression, as measured by immunohistochemical analysis, was observed in 183 of 383 breast carcinomas, 39 of 217 ovarian carcinomas, and 16 of 24 and 17 of 24 hormonesensitive and hormone-insensitive prostate carcinomas, respectively. HER4 expression was detected in breast carcinomas by using 2 antibodies recognizing an extracellular or intracellular epitope. TACE expression was predominantly seen in tumors with high levels of 4ICD and membranous HER4. Apoptotic activity was measured by the terminal deoxynucleotidyl transferase-mediated nick-end labeling (TUNEL) assay and cleaved caspase-3 staining in breast carcinomas. There was no significant association between cleaved caspase-3 or TUNEL positivity and 4ICD, whereas TUNEL positivity was seen predominantly in tumors with high levels of internalized HER4. The data presented herein show TACE expression in endocrine cancers and further support a role for TACE in breast cancer apoptosis.
Haemodynamic effects of hydrallazine and of hydrallazine plus glyceryl trinitrate paste in heart failure. (1978)

In a study designed to investigate potential non-parenteral treatment for chronic heart failure, hydrallazine, 225 to 300 mg per day, was given orally to 9 patients. There was no significant change in heart rate or mean arterial pressure as cardiac output increased. Left ventricular stroke work increased significantly and pulmonary artery wedge pressure fell. Systemic and pulmonary vascular resistances fell. With the addition of 2 per cent glyceryl trinitrate paste, there was a further decline in mean pulmonary arterial and wedge pressures, without a significant change in heart rate, arterial pressures, cardiac output, or systemic or pulmonary vascular resistance. There were no untoward effects from either form of treatment. All patients reported relief of shortness of breath and other symptoms related to ventricular dysfunction. This study supports the suggestion that oral hydrallazine is effective in increasing cardiac output and decreasing pulmonary congestion. Furthermore, the addition of topical glyceryl trinitrate provides a greater reduction of pulmonary pressures, probably through its predominant venodilator action. In some selected patients with heart failure, oral hydrallazine and topical glyceryl trinitrate in combination produce beneficial clinical and haemodynamic effects, probably through afterload and preload reduction, respectively.
Castor oil–citric acid copolyester for tissue augmentation (2014)

Biodegrable polyesters derived from hydroxy acids have a broad clinical use. The aim of the study was to synthesize polymer compositions based on citric acid and castor oil for use as soft tissue augmentation. Two polymers were synthesized, a branched viscous polyester with a monomer ratio of 93.5:6.5 w/w and an apparent molecular weight of 11,000 Da and a crosslinked semisolid polymer with a monomer ratio of 92.5:7.5 w/w. The branched polymer lost less than 10% of its weight during a 30‐day degradation study. In vivo biocompatibility study in rats showed 20% formulation weight loss 9 months post‐subcutaneous administration. These results were in accordance with the in vitro hydrolytic degradation of the polymer. The in vivo study revealed good tolerability of the copolymer. Copyright © 2014 John Wiley &amp; Sons, Ltd.
High speed 2D-PDA FSO receiver for high optical alignment robustness with space diversity (2020)

We present a free space optics receiver with high robustness for optical alignment using a large active area, high-speed 2D-PDA, and its demonstration of 40-Gbps (PAM4) signal detection using a space diversity technique in DSP.
Bridging Utility Maximization and Regret Minimization (2014)

We relate the strategy sets that a player ends up with after refining his own strategies according to two very different models of rationality: namely, utility maximization and regret minimization.
Structural Characterization of a Rigidified Threading Bisintercalator (2007)

NMR spectroscopy was used to explore the sequence-specific interaction of DNA with a new threading bisintercalator (C1) consisting of two intercalating 1,4,5,8-naphthalenetetracarboxylic diimide (NDI) units connected by a rigid, tricyclic spiro linker. A structural model of C1 complexed to d(CGGTACCG)2 was calculated using distance constraints obtained from solution NMR data. The model was also supported by the results from residual dipolar coupling (RDC) measurements obtained using Pf1-phage as a cosolvent. According to the model, the central cyclohexane ring of the linker connecting the two NDI units lies flat in the minor groove of DNA. Linker length, hydrogen bonding, steric, and hydrophobic factors all appear to contribute to the observed sequence specificity of binding. These results serve to illustrate the versatility of threading polyintercalation given that, in a previous study, a ligand consisiting of two NDI units joined by a flexible peptide linker was shown to bind sequence specifically within the major groove of this same sequence of DNA.
Turn-off performance of 2.6 kV 4H-SiC asymmetrical GTO thyristor (2001)

4H-SiC asymmetrical gate turn-off thyristors (GTOs) with 2.6 kV breakover voltage have been studied in relation to the gate turn-off performance. Transient characteristics of SiC GTOs and the pulse regime of gate turn-off processes were studied in the temperature range 293 to 500 K. At cathode current density of 300 A cm-2, a turn-off current gain KG of 12.5 was achieved at room temperature. The above value of KG is the highest reported for SiC GTOs. The temperature dependences of the turn-off time, pulse turn-off gate current and holding current were studied.
Speed-limiting factors in flash-type Josephson A/D converters (1989)

The authors discuss the causes of speed limitations in various A/D (analog/digital) converter designs. The upper limit on bandwidth is extracted with the help of Josephson SPICE simulations. In the Josephson A/D converter circuits discussed, the dynamic properties of the SQUIDs (superconducting quantum interference devices) determine the aperture time and dictate the bandwidth. Designs for 4-bit A/D converters that show potential for bandwidths on the order of 10 GHz are described. Particular attention is given to the bit-parallel A/D converter with self-gating AND comparator and bit-parallel A/D converters with CLAM (current latching analog microcomparator) and variable-pulse peak comparators.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Figure 2 from Androgen Deprivation Followed by Acute Androgen Stimulation Selectively Sensitizes AR-Positive Prostate Cancer Cells to Ionizing Radiation (2023)

&lt;p&gt;Formation of androgen induced DSB requires AR and TOP2B.&lt;/p&gt;
Comments on "Min-norm interpretations and consistency of MUSIC, MODE, and ML" (1998)

For original paper see Ephraim et al. (IEEE Trans. Signal Processing, vol.43, p.2937-42, 1995 December). The results and interpretations obtained in the original paper are shown to be well known or obvious. Additionally, corrections to some misleading statements are presented.
Comment on mr-2022-9 (2022)

<strong class="journal-contentHeaderColor">Abstract.</strong> Since the dawn of quantum mechanics, ways to visualize spins and their interactions have attracted the attention of researchers and philosophers of science. In this work we present a generalized measurement-based 3D-visualization approach for describing dynamics in strongly coupled spin ensembles. The approach brings together angular momentum probability surfaces (AMPS), Husimi <span class="inline-formula"><i>Q</i></span> functions, and DROPS (discrete representations of operators for spin systems) and finds particular utility when the total angular momentum basis is used for describing Hamiltonians. We show that, depending on the choice of a generalized measurement operator, the plotted surfaces either represent probabilities of finding the maximal projection of an angular momentum along any direction in space or represent measurable coherences between the states with different total angular momenta. Such effects are difficult to grasp by looking at (time-dependent) numerical values of density-matrix elements. The approach is complete in a sense that there is one-to-one correspondence between the plotted surfaces and the density matrix. Three examples of nuclear spin dynamics in two-spin systems are visualized: (i)Â a zero- to ultralow-field (ZULF) nuclear magnetic resonance (NMR) experiment in the presence of a magnetic field applied perpendicularly to the sensitive axis of the detector, (ii)Â interplay between chemical exchange and spin dynamics during high-field signal amplification by reversible exchange (SABRE), and (iii)Â a high-field spin-lock-induced crossing (SLIC) sequence, with the initial state being the singlet state between two spins. The presented visualization technique facilitates intuitive understanding of spin dynamics during complex experiments as exemplified here by the considered cases. Temporal sequences (âthe moviesâ) of such surfaces show phenomena like interconversion of spin order between the coupled spins and are particularly relevant in ZULF NMR.
Tau-Based Therapeutic Approaches for Alzheimer's Disease - A Mini-Review (2014)

The accumulation of aggregated, hyperphosphorylated tau as neurofibrillary tangles and neuropil threads are cardinal features of Alzheimer's disease (AD). The other lesions found in AD include amyloid plaques and congophilic amyloid angiopathy, both associated with the extracellular accumulation of the amyloid-beta (Aβ) peptide. AD is the most common cause of dementia globally. Currently, there are no effective means to treat AD or even to slow it down. The dominant theory for the causation of AD is the amyloid cascade hypothesis, which suggests that the aggregation of Aβ as oligomers and amyloid plaques is central to the pathogenesis of AD. Numerous therapies have been developed directed to Aβ-related pathology, in particular various immunotherapeutic approaches. So far all of these have failed in clinical trials. Recently, there has been more focus on therapy directed to tau-related pathology, which correlates better with the cognitive status of patients, compared to the amyloid burden. Immunotherapeutic targeting of tau pathology has shown great potential in treating tau pathologies in mouse models of AD. A number of studies have shown the efficacy of both passive and active immunization. This review summarizes recent advances in therapy targeting pathological tau protein, in particular focusing on immunotherapeutic approaches which are showing great promise.
Deciphering the Peculiar Behavior of β-Lapachone in Lipid Monolayers and Bilayers (2019)

β-Lapachone (β-Lap) is a promising anticancer drug whose applications have been limited so far because of its poor solubility and stability. Its encapsulation in liposomes has been proposed to overcome these issues. However, surface pressure measurements show that β-Lap exhibits atypical interfacial behavior when mixed with lipids. Although the drug does not seem to be retained in lipid monolayers as deduced from the π-<i>A</i> isotherms, small changes in compressibility moduli suggest that β-Lap actually interacts with lipids, either disorganizing or rigidifying their monolayers. Thermal and structural analyses of lipid bilayers confirm the existence of β-Lap/lipid interactions and show that the drug inserts between hydrophobic chains, close to the polar headgroup in DPPC bilayers and deeper in the acyl chains in POPC bilayers. Molecular dynamics simulations allow a comprehensive description of the drug position and orientation in DOPC and POPC bilayers in the presence or absence of cholesterol.
[Beta-adrenergic receptivity and left ventricular hypertrophy caused by pressure overload in man]. (1993)

The effect of left ventricular chronic pressure overload on right atrial (RA) and left ventricular (LV) myocardial beta-adrenoceptor (beta-AR) density and subtypes ([I125] cyanopindolol binding), adenylate cyclase activity (AC) and ADP-pertussis toxin ribosylated proteins was investigated in 13 patients with aortic stenosis (AO) and compared with the results obtained in 10 patients with mitral stenosis (MI) taken as controls. None of the patients included had any impairement of systolic function or increased plasma catecholamine levels. The total number of beta-AR in RA (62 +/- 6 vs 77 +/- 12 fmoles/mg prot) and LV (39 +/- 7 vs 32 +/- 2 fmoles/mg prot) was similar in AO and in MI. The percentage of beta 1-AR was significantly lower in LV from AO (35 +/- 11 vs 73 +/- 5% in MI) but identical in RA (79 +/- 5 vs 73 +/- 8%). The basal activity of AC was similar in membranes from patients with AO (19 +/- 4 and 22 +/- 5 pmol.mg-1 prot in RA and LV) and in controls (21 +/- 6 and 27 +/- 3 pmol.mg-1 prot in RA and LV). Isoprenaline-induced stimulation of AC was significantly lower in LV membranes from patients with AO (7 +/- 6 vs 45 +/- 6% in MI) but remained identical in RA membranes (51 +/- 18 vs 36 +/- 18% in MI). The quantification of ADP-pertussis toxin ribosylated proteins indicated a lower substrate concentration in myocardial membranes from patients with AO when compared with controls.(ABSTRACT TRUNCATED AT 250 WORDS)