gebhart/patrepeval huggingface dataset:
Superconductor-to-metal transition in overdopedLa2−xSrxCuO4 (1994)

The low-temperature transition from superconductor to metal of overdoped ${\mathrm{La}}_{2\mathrm{\ensuremath{-}}\mathit{x}}$${\mathrm{Sr}}_{\mathit{x}}$${\mathrm{CuO}}_{4}$ has been monitored by measurements of resistivity versus temperature as a function of pressure over the compositional range 0.15\ensuremath{\le}x\ensuremath{\le}0.30. Polycrystalline samples were annealed under oxygen for periods up to 1 month to obtain homogeneous, stoichiometric samples. The pressure dependence of the critical temperature is ${\mathit{dT}}_{\mathit{c}}$/dP&gt;0 in the orthorhombic phase found for x\ensuremath{\le}0.22; it vanishes in the tetragonal phase occurring with x&gt;0.22. Pressure favors the tetragonal phase, lowering the orthorhombic-tetragonal transition temperature ${\mathit{T}}_{\mathit{t}}$ and shifting the transitional composition ${\mathit{x}}_{\mathit{t}}$ to ${\mathit{x}}_{\mathit{t}}$0.20 above 10 kbar. This shift is shown to be due to an unusually large compressibility of the Cu-O bonds in the ${\mathrm{CuO}}_{2}$ sheets. The persistence of ${\mathit{T}}_{\mathit{c}}$ into the tetragonal phase with x&gt;${\mathit{x}}_{\mathit{t}}$ is not due to orthorhombic-phase fluctuations, as has been speculated. Whereas the superconductive transition temperature ${\mathit{T}}_{\mathit{c}}$ decreases with increasing x, an elastic transition at ${\mathit{T}}_{\mathit{d}}$\ensuremath{\approxeq}37 K persists over the entire compositional range, including the metallic phase at x=0.30. Careful measurements of resistance and Seebeck coefficient across ${\mathit{T}}_{\mathit{d}}$ reveal a ${\mathit{T}}_{\mathit{d}}$\ensuremath{\ge}${\mathit{T}}_{\mathit{c}}$; but superconductive-pair fluctuations may occur below a ${\mathit{T}}_{\mathit{f}}$&gt;${\mathit{T}}_{\mathit{d}}$ where ${\mathit{T}}_{\mathit{c}}$\ensuremath{\approxeq}${\mathit{T}}_{\mathit{d}}$, which is consistent with a transition from two- to three-dimensional metallic conduction. The data also suggest that the superconductor-metal transition is not smooth.
SYGMA: A System for Generalizable and Modular Question Answering Over Knowledge Bases (2022)

Sumit Neelam, Udit Sharma, Hima Karanam, Shajith Ikbal, Pavan Kapanipathi, Ibrahim Abdelaziz, Nandana Mihindukulasooriya, Young-Suk Lee, Santosh Srivastava, Cezar Pendus, Saswati Dana, Dinesh Garg, Achille Fokoue, G P Shrivatsa Bhargav, Dinesh Khandelwal, Srinivas Ravishankar, Sairam Gurajada, Maria Chang, Rosario Uceda-Sosa, Salim Roukos, Alexander Gray, Guilherme Lima, Ryan Riegel, Francois Luus, L V Subramaniam. Findings of the Association for Computational Linguistics: EMNLP 2022. 2022.
Cycolor ® Imaging Technology (1989)

Mead Imaging is commercializing Cycolor<sup>®</sup>, a revolutionary photoimaging system which will have broad applications in color copying and reproduction, referred to as cylithography. Cycolor possesses the following characteristics: &bull; panchromatic sensitivity &bull; dry processing &bull; high resolution &bull; continuous tone &bull; high color quality &bull; low cost. The Cycolor system is a result of work carried out at Mead Corporation over the past several years on the microencapsulated process.
IgG4 but no IgG1 antibody production after intralymphatic immunotherapy with recombinant MAT‐Feld1 in human (2016)

Allergy immunotherapy (AIT) mediates protection against allergen exposure in part due to allergen-specific antibodies. While immunization typically stimulated IgG1 and IgG2, AIT is often associated with production of IgG4. Here, twenty cat dander-sensitized patients were randomized to receive three injections of intralymphatic immunotherapy (ILIT) with MAT-Feld1 adsorbed to aluminum hydroxide or just aluminum hydroxide (placebo) in a double-blind setting (ClinicalTrials.gov NCT00718679). Whereas the clinical data, showing benefit of Mat-Feld1 ILIT was published in 2012 (Senti et al., J Allergy Clin Immunol, vol 129(5):1290-1296), the current study investigated the cat allergen-specific antibody responses. Blood was drawn prior to ILIT, as well as 1, 3, and 12 months after first ILIT. The sera were analyzed to characterize all IgG subclasses and IgE antibody responses. ILIT with MAT-Feld1 elicited high levels of total IgG that were maintained for at least 12 months. Interestingly, a strong increase in IgG4 and some increase in IgG2 were observed throughout the study, while production of cat-specific IgG1 and IgG3 was not stimulated by MAT-Feld1 ILIT. The IgE levels remained constant.
STRAIN-INDUCED TISSUE REMODELING IN EX VIVO BLADDER ORGAN CULTURE: IMPLICATIONS FOR REGENERATIVE MEDICINE (2008)

You have accessJournal of Urology1 Apr 2008STRAIN-INDUCED TISSUE REMODELING IN EX VIVO BLADDER ORGAN CULTURE: IMPLICATIONS FOR REGENERATIVE MEDICINE Rebecca A Long, Aron Parekh, Michael B Chancellor, and Michael Sacks Rebecca A LongRebecca A Long More articles by this author , Aron ParekhAron Parekh More articles by this author , Michael B ChancellorMichael B Chancellor More articles by this author , and Michael SacksMichael Sacks More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)61018-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "STRAIN-INDUCED TISSUE REMODELING IN EX VIVO BLADDER ORGAN CULTURE: IMPLICATIONS FOR REGENERATIVE MEDICINE." The Journal of Urology, 179(4S), p. 348 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 348 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Rebecca A Long More articles by this author Aron Parekh More articles by this author Michael B Chancellor More articles by this author Michael Sacks More articles by this author Expand All Advertisement PDF downloadLoading ...
The Mycobacterium tuberculosis ECF sigma factor σE: role in global gene expression and survival in macrophages† (2001)

In previously published work, we identified three Mycobacterium tuberculosis sigma (σ) factor genes responding to heat shock ( sigB , sigE and sigH ). Two of them ( sigB and sigE ) also responded to SDS exposure. As these responses to stress suggested that the σ factors encoded by these genes could be involved in pathogenicity, we are studying their role in physiology and virulence. In this work, we characterize a sigE mutant of M. tuberculosis H37Rv. The sigE mutant strain was more sensitive than the wild‐type strain to heat shock, SDS and various oxidative stresses. It was also defective in the ability to grow inside both human and murine unactivated macrophages and was more sensitive than the wild‐type strain to the killing activity of activated murine macrophages. Using microarray technology and quantitative reverse transcription–polymerase chain reaction (RT–PCR), we started to define the σ E regulon of M. tuberculosis and its involvement in the global regulation of the stress induced by SDS. We showed the requirement for a functional sigE gene for full expression of sigB and for its induction after SDS exposure but not after heat shock. We also identified several genes that are no longer induced when σ E is absent. These genes encode proteins belonging to different classes including transcriptional regulators, enzymes involved in fatty acid degradation and classical heat shock proteins.
Electromagnetic Interaction Between the Component Coils of Multiplex Magnets (2017)

Ultra-high field the pulsed magnets are usually designed as a group of nested, concentric coils driven by separated power sources to reduce the required driving voltages and to distribute the mechanical load. Since the magnet operates in a fast transient mode, there will be strong and complicated electromagnetic couplings between the component coils. The high eddy currents generated in the reinforcement shells of the component coils during the pulses also strongly affect these couplings. Therefore, understanding the electromagnetic interaction between the component coils will allow safer, more optimized design and operation of our magnets. This paper will focus on our finite element modeling and experimental results for the electromagnetic interactions between the component coils of the 100-T nondestructive magnet and 80-T duplex magnet at our facility.
Visualization of Gene Reciprocity among Lactic Acid Bacteria in Yogurt by RNase H-Assisted Rolling Circle Amplification-Fluorescence In Situ Hybridization (2021)

Recently, we developed an <i>in situ</i> mRNA detection method termed RNase H-assisted rolling circle amplification-fluorescence <i>in situ</i> hybridization (RHa-RCA-FISH), which can detect even short mRNA in a bacterial cell. However, because this FISH method is sensitive to the sample condition, it is necessary to find a suitable cell permeabilization and collection protocol. Here, we demonstrate its further applicability for detecting intrinsic mRNA expression using lactic acid bacteria (LAB) as a model consortium. Our results show that this method can visualize functional gene expression in LAB cells and can be used for monitoring the temporal transition of gene expression. In addition, we also confirmed that data obtained from bulk analyses such as RNA-seq or microarray do not always correspond to gene expression in individual cells. RHa-RCA-FISH will be a powerful tool to compensate for insufficient data from metatranscriptome analyses while clarifying the carriers of function in microbial consortia. By extending this technique to capture spatiotemporal microbial gene expression at the single-cell level, it will be able to characterize microbial interactions in phytoplankton-bacteria interactions.
High-Speed High-Resolution 1200 dpi LED Print Head (2001)

We have developed a new 1200 dots-per-inch (dpi) light emitting diode (LED) print head for high-quality digital color printers in the next generation. The LED print head is suitable for high-speed color printer print heads. In order to achieve the high performance of the LED print head, we have developed an original 1200 dpi LED array chip with matrix structured wiring. Moreover, the LED array chip realizes a &#x201C;Low cost LED print head&#x201D; in which the number of bonding wires and driver integrated circuit (IC) chips on the LED print head has been decreased to less than half, compared to the conventional 1200 dpi print head.
Compressor Volute Design System: Part II — New Volute Design System Approach (2002)

Volutes are widely used in industrial process, refrigeration system, small gas turbines and gas pipeline centrifugal compressors as the transition from the impeller-diffuser to the pipings, because of their simple structure, ease of production and wide operating range. This paper illustrates a new design tool that incorporates a new volute design system that integrates and automates geometry generation, grid generation and aerodynamic analysis. In optimizing the available technology in terms of grid generation, CFD, and computer graphics, the program will utilize existing technology used by industry to generate a powerful volute design tool. The design tool is programmed in a way that integrates the features and methods a designer would use for volute design. This is fundamentally by means of geometrical constraints and/or functional relationships. Grids can be generated in minutes accommodating geometrical changes thus reducing the bottlenecks associated with geometry/grid generation for CFD applications. Prior to most CFD analysis work, a structured grid must be produced ensuring high quality such that convergence is assured and the time to convergence of the solution is minimized. However, there are usually only a few people that have the required skills to produce the geometry and generate a high quality structured grid. In essence, the tool provides a sidestep around both the geometry generation and the grid generation process. It automates the process such that anybody can produce a high quality grid from the geometry and move straight to the CFD component of the work and hence can incorporate CFD as part of the design process. The volute design tool will enable the user to generate a family of volutes and display 2D volute cross sections and 3D solid models of the scroll, diffuser inlet, discharge conic, and connecting channel. Separate interfaces will be written to accommodate the different operating systems. The geometry generation will be written in windows however, a separate interface will be written to produce the grid being compatible in NT, Unix, and Linux platforms.
Strategies for Discovering Kinase Drugs (2008)

This chapter contains sections titled: Introduction Protein Kinase Structural Features Generating and Optimizing Kinase Inhibitors Establishing Screens for Understanding Kinase Activity and Selectivity Case Studies of Successful Kinase Drug Discovery References
High-Frequency Ultrasound-Guided Injection for the Generation of a Novel Orthotopic Mouse Model of Human Thyroid Carcinoma (2016)

This study demonstrated the technical feasibility of an HFUS-guided orthotopic mouse model of FTC. The HFUS-guided orthotopic model is easily reproducible and allows prolonged monitoring of the disease because the animals showed an increased survival rate.
Online identification of directional graph topologies capturing dynamic and nonlinear dependencies (2018)

Linear structural vector autoregressive models (SVARMs) have well-documented merits for topology inference of directional graphs emerging in diverse applications, including gene-regulatory, brain, and social networks. Although simple and tractable, linear SVARMs cannot capture nonlinearities that are inherent to complex systems, such as the human brain, that can also vary over time. Given nodal measurements, these considerations motivate the dynamic nonlinear SVARM approach developed here to track the possibly directed and dynamic nonlinear interactions among network nodes. For slow-varying topologies, nonlinear model parameters are estimated via functional stochastic gradient descent. Numerical tests showcase the effectiveness of the novel algorithms in unveiling sparse dynamically-evolving topologies.
Phase transition in bulk single crystals and thin films ofVO2by nanoscale infrared spectroscopy and imaging (2015)

Infrared spectroscopy of VO${}_{2}$ thin films at high spatial resolution shows new electronic and lattice states due to epitaxial strain that differ fundamentally from those in the bulk. This is the first ultra-broadband infrared near-field study of a correlated electron material, made possible by the newly developed synchrotron infrared near-field spectroscopy method (SINS) on the Advanced Light Source at Lawrence Berkeley National Laboratory.
Anaerobic glycolysis and lactate dehydrogenase (LDH) isoenzymes in articular cartilage. (1969)

Abstract The production of lactate by slices of bovine articular cartilage incubated in vitro remains unchanged despite deprivation of oxygen or the addition of 10 −3 or 10 −4 M of sodium cyanide. Lactate generation is markedly lowered in the presence of 10 −4 M of sodium monoiodoacetate (MIA) and increased by 10 −4 M dinitrophenol (DNP). The LDH isoenzyme pattern of articular cartilage from rabbit, cow, and man contains mostly LDH 4 and LDH 5 isoenzymes, which have been suggested as facilitators of anaerobic glycolysis. These findings suggest that anaerobic metabolism (glycolysis) is the major pathway for energy generation in articular cartilage. They further suggest that the function of mitochondria in articular cartilage might be substantially different from mitochondrial function in most other tissues.
Multilamellar Nanoparticles Self-Assembled from Opposite Charged Blends: Insights from Mesoscopic Simulation (2015)

Multilamellar nanoparticles (NPs) are spontaneously formed when mixing two components with opposite charges, meaningful for drug delivery. However, details of NPs association and mechanisms of this process remain largely unknown, due to the limitation of experimental technique. In this work, we use dissipative particle dynamics (DPD) simulation for the first time to determine the structure–property relationships of multilamellar NPs formed by charged blends. As a case study, a system with polyanionic fondparinux (Fpx) and cationic derivatives squalenoyl (CSq, including Sq+ and Sq++) in aqueous media is investigated, with a focus on the optimized formation condition and mechanism of regular spherical multilamellar NPs. In particular, we find that highly ordered multilamellar structures tend to form when the nonbonded interaction between Fpx–CSq and hydrophobic interaction contributed by CSq are well-balanced. The DPD results strongly agree with corresponding experimental results of this novel nanoparticulate drug carrier. This study could help develop promising multilamellar NPs formed by charged blends through self-assembly for drug delivery.
Measurement of differential and integrated fiducial cross sections for Higgs boson production in the four-lepton decay channel in pp collisions at s = 7 $$ \sqrt{s}=7 $$ and 8 TeV (2016)

Integrated fiducial cross sections for the production of four leptons via the H 4 decays ( = e, ) are measured in pp collisions at s = 7 and 8 TeV. Measurements are performed with data corresponding to integrated luminosities of 5.1 fb -1 at 7 TeV, and 19.7 fb -1 at 8 TeV, collected with the CMS experiment at the LHC. Differential cross sections are measured using the 8 TeV data, and are determined as functions of the transverse momentum and rapidity of the four-lepton system, accompanying jet multiplicity, transverse momentum of the leading jet, and difference in rapidity between the Higgs boson candidate and the leading jet. A measurement of the Z 4 cross section, and its ratio to the H 4 cross section is also performed. All cross sections are measured within a fiducial phase space defined by the requirements on lepton kinematics and event topology. The integrated H 4 fiducial cross section is measured to be 0.56 +0.67 -0.44 (stat) +0.21 -0.06 (syst) fb at 7 TeV, and 1.11 +0.41 -0.35 (stat) +0.14 -0.10 (syst) fb at 8 TeV. The measurements are found to be compatible with theoretical calculations based on the standard model.
Dynamic 3D chromosomal landscapes in acute leukemia (2019)

ABSTRACT Three-dimensional (3D) chromatin architectural changes can alter the integrity of topologically associated domains (TADs) and rewire specific enhancer-promoter interactions impacting gene expression. Recently, such alterations have been implicated in human disease, highlighting the need for a deeper understanding of their role. Here, we investigate the reorganization of chromatin architecture in T cell acute lymphoblastic leukemia (T-ALL) using primary human leukemia specimens and its dynamic responses to pharmacological agents. Systematic integration of matched in situ Hi-C, RNA-Seq and CTCF ChIP-Seq datasets revealed widespread changes in intra-TAD chromatin interactions and TAD boundary insulation in T-ALL. Our studies identify and focus on a TAD “fusion” event being associated with loss of CTCF-mediated insulation, enabling direct interactions between the MYC promoter and a distal super-enhancer. Moreover, our data show that small molecule inhibitors targeting either oncogenic signal transduction or epigenetic regulation reduce specific 3D interactions associated with transformation. Overall, our study highlights the impact, complexity and dynamic nature of 3D chromatin architecture in human acute leukemia. One Sentence Summary 3D chromatin alterations in T cell leukemia are accompanied by changes in insulation and oncogene expression and can be partially restored by targeted drug treatments.
Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor α (2006)

These data show that arthritis is sufficiently initiated and maintained in tmTNFalpha-transgenic/TNFalpha-KO mice, and that it can be neutralized by recombinant human p55 or p75 sTNFR, resulting in amelioration of the biologic and subsequent histologic destructive effects of tmTNFalpha.
Antiangiogenic tetrathiomolybdate enhances the efficacy of doxorubicin against breast carcinoma. (2003)

Constitutive activation of nuclear factor kappaB is implicated to be a critical survival mechanism used by carcinoma cells to escape apoptosis. Tetrathiomolybdate (TM), a novel copper chelator, exhibits potent antiangiogenic properties, in part, through suppression of the nuclear factor kappaB signaling cascade. In this study, we determined whether TM enhances doxorubicin-induced apoptosis in SUM149 inflammatory breast carcinoma cells. Apoptosis was not observed in these cells after TM treatment. Moreover, SUM149 cells were relatively resistant to doxorubicin-induced apoptosis ranging from 9.9 +/- 2.9% to 21.5 +/- 2.0% apoptotic cells for 0.1 to 2.5 micro M doxorubicin treatment. A greater-than-additive increase (33.8 +/- 4.6%, 57.5 +/- 5.2%, or 83.7 +/- 1.0% apoptosis with TM and 0.1, 0.5, or 2.5 micro M doxorubicin, respectively) in apoptosis was observed in cells treated with the combination therapy of TM and doxorubicin. In SUM149 xenografts, TM and doxorubicin significantly retarded tumor growth in comparison with either agent administered alone (P < 0.03). Tumor cell apoptosis in the combination therapy-treated mice was 113.3 +/- 20% greater than that in TM-treated mice and 52.4 +/- 14.3% greater than that in doxorubicin-treated mice. These results suggest that TM may enhance the rate of pathological complete response when used in combination with an anthracycline in neoadjuvant therapy of breast carcinoma.
Solid‐phase synthesis of uniform linear oligoethers with repeating functional arms as multivalent spacers (2010)

Polystyrene-bound uniform linear oligoethers, where each repeating unit bears a functional arm, were prepared by stepwise solid-phase synthesis. These oligomeric spacers are an alternative to dendritic oligoethers and preserve the multivalent nature of the latter. L-Proline, immobilized on the support equipped with such oligomeric spacers, induced in the model aldol reaction activity and selectivity, comparable to those of the proline immobilized on a related dendronized support. The functional side chains of the oligoethers can be dendronized, thus increasing, even more, the local density of the functional groups near each attachment site on the polystyrene matrix. Additional Supporting Information may be found in the online version of this article. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Changing Patterns of H6 Influenza Viruses in Hong Kong Poultry Markets (2010)

Until 2001, H6N1 influenza viruses in the Hong Kong bird markets were represented by a single stable A/teal/Hong Kong/W312/97-like lineage. Beginning in 2001, despite a reduction in overall prevalence, an increase was observed in the number of H6 viruses isolated from chickens and other hosts. To assess any changes in H6 viruses, we characterized 18 H6 viruses isolated in the Hong Kong bird markets from 2001 to 2003. Experimental data showed that the 2003 H6 viruses had similar infectivity for chickens as did A/teal/HK/W312/97, and they were unable to transmit. Although all hemagglutinin genes were closely related to A/teal/HK/W312/97, 7 isolates were reassortant viruses containing similar gene segments of co-circulating H9N2 or H5N1 viruses. The receptor specificity was different from that of A/teal/Hong Kong/W312/97. Interestingly, similar observations have been documented in H9N2 viruses in Hong Kong. This evolution strongly suggests that some change in the ecology of influenza in the region selected for these changes. Taken together, these findings suggest that the H6 influenza viruses isolated in the Hong Kong markets are not well adapted to chickens and that the likely continued source of these viruses are other "minor" poultry species in which they are undergoing genetic and biologic evolution.