gebhart/patrepeval huggingface dataset:
Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in aged mice in a sex-specific manner (2022)

Abstract Evidence for hypothalamic regulation of energy homeostasis and thermoregulation in brown adipose tissue (BAT) during aging has been well recognized, yet the central molecular mediators involved in this process are poorly understood. The arcuate hypothalamus (ARC), orexigenic agouti-related peptide (AgRP) neurons control nutrient intake, energy homeostasis, and BAT thermogenesis. To determine the roles of growth hormone receptor (GHR) signaling in the AgRP neurons we used mice with the AgRP-specific GHR deletion (AgRP ΔGHR ). We found that female AgRP ΔGHR mice were resistant to temperature adaptation, and their body core temperature remained significantly lower when held at 10°C, 22°C, or 30°C, compared to control mice. Low body core temperature in female AgRP ΔGHR mice has been associated with significant reductions in Ucp1 and Pgc1α expression in the BAT. Further, neuronal activity in AgRP in response to cold exposure was blunted in AgRP ΔGHR females, while the number of Fos + AgRP neurons was increased in control females exposed to cold. Global transcriptome from BAT identified increased expression of genes related to immune responses and chemokine activity and decreased expression of genes involved in triglycerides synthesis and metabolic pathways in AgRP ΔGHR females. Importantly, these were the same genes that are downregulated by thermoneutrality in control mice but not in the AgRP ΔGHR animals. Collectively, these data demonstrate a novel circuit of thermal regulation between the hypothalamic AgRP-GHR and BAT and provide insight into the brain systems that are critical for the thermogenic vitality of the elderly.
Electrically tunable resonant filters in phase-shifted contra-directional couplers (2012)

We demonstrate an electrically tunable resonant filter with FSR-free operation using a silicon photonic quarter-wavelength phase-shifted, grating-assisted contra-directional coupler. The spectrum shows a stop-band of 7nm, an extinction of 24dB, and a Q of 7,000.
Neisseria meningitidis expressing lgtB lipopolysaccharide targets DC-SIGN and modulates dendritic cell function (2005)

Neisseria meningitidis lipopolysaccharide (LPS) has been identified as a major determinant of dendritic cell (DC) function. Here we report that one of a series of meningococcal mutants with defined truncations in the lacto-N-neotetraose outer core of the LPS exhibited unique strong adhesion and internalization properties towards DC. These properties were mediated by interaction of the GlcNAc(beta1-3)-Gal(beta1-4)-Glc-R oligosaccharide outer core of lgtB LPS with the dendritic-cell-specific ICAM-3 grabbing non-integrin (DC-SIGN) lectin receptor. Activation of DC-SIGN with this novel oligosaccharide ligand skewed T-cell responses driven by DC towards T helper type 1 activity. Thus, the use of lgtB LPS may provide a powerful instrument to selectively induce the desired arm of the immune response and potentially increase vaccine efficacy.
Facing the challenge: developing and validating approaches for the detection and quantification of skin-sensitizing hydroperoxides in consumer products. 13th Congress of the European Society of Contact Dermatitis, Manchester, Royaume-Uni (2016)

Facing the challenge: developing and validating approaches to detect and quantify skin sensitizing hydroperoxides in consumer products Recently, a high frequency of positive patch tests to oxidized linalool and limonene was reported from multiple clinical centers.However, there is a lack of data indicating potential sources of consumer exposure to sensitizing doses of terpene hydroperoxides, which are the key sensitizers in preparations of these oxidized materials.To understand the frequent patch tests and define potential actions needed, this gap needs to be closed.Within the IDEA project (International Dialogue for the Evaluation of Allergens), three workshops were organized to look at the clinical data, the conditions leading to hydroperoxide formation and the question of significant exposure to hydroperoxides from fragranced products.IDEA formulated a program that will drive analytical and mechanistic understanding of these potential reactions which eventually will allow to develop a framework, broadly applicable to address the Pre/Pro-Hapten question in a meaningful approach.As one key action, a hydroperoxide analytical taskforce was established.This group (i) reviewed the analytical challenge, (ii) organized a reliable source for pure analytical standards, and (iii) started two method evaluation studies to compare different analytical methods to detect hydroperoxides in essential oils.LC-MS and GC-MS methods with derivatization were tested.Based on the results of these initial steps, a new study was planned to compare one promising and relatively simple method for reproducibility between laboratories.At the same time, a broad range of different methods were compared on the same products.All these analysis was done on two real-life consumer products (eau de parfume and eau de toilette) spiked with defined, but blinded, levels of hydroperoxides.Full results of this study will be presented to give a perspective on the status of this IDEA guided project and discuss the remaining analytical challenge to truly measure exposure of the public to sensitizing hydroperoxides.
Designing internal control points in partially managed processes by using business vocabulary (2011)

The challenges of automatically detecting compliance failures in partially managed processes are addressed and a solution is proposed. Detecting compliance failures by creating internal controls is a requirement of enterprise risk management framework. In case of unmanaged or partially managed processes, lack of full process visibility and the dependence on in depth knowledge of IT system and business application code are the main challenges of generating internal controls. Integration of business provenance management system with a business rule management system is proposed to overcome these challenges.
Structure and Shape Effects of Molecular Glue on Supramolecular Tubulin Assemblies (2013)

The possibility to arrange biological molecules into ordered nanostructures is an important issue in nano- and biotechnology. Nature offers a wide range of molecular "bricks" (e.g., proteins, oligonucleotides, etc.) that spontaneously assemble into more complex hierarchical systems with unique functionalities. Such molecular building blocks can be also used for the construction of nanomaterials with peculiar properties (e.g., DNA origami). In some cases, molecular glues able to bind biomolecules and to induce their assembly can be used to control the final structure and properties in a convenient way. Here we provide molecular-level description of how molecular glues designed to stick to the surface of microtubules (MTs) can control and transform the α/β-tubulin assembly upon temperature decreasing. By means of all-atom molecular dynamics (MD) simulations, we compared the adhesion to the MT surface of three molecular glues bearing the same guanidinium ion surface adhesive groups, but having different architecture, i.e., linear or dendritic backbone. Our evidence demonstrates that the adhesive properties of the different molecular glues are dependent on the shape they assume in solution. In particular, adhesion data from our MD simulations explain how globular- or linear-like molecular glues respectively stabilize MTs or transform them into a well-defined array of α/β-tubulin rings at 15 °C, where MTs naturally depolymerize. The comprehension of the MT transformation mechanism provides a useful rationale for designing ad hoc molecular glues to obtain ordered protein nanostructures from different biological materials.
Safety and effectiveness of combined ECT and clozapine in treatment-resistant mania (1996)

Two cases of patients with acute mania who responded to combined electroconvulsive therapy (ECT) and clozapine are described. This report further demonstrates the efficacy and safety of clozapine-ECT co-administration in schizoaffective patients.
A 3D Unsteady Flow Analysis in a Doubly Constricted Tube (2000)

Abstract Unsteady flow dynamics in a doubly constricted vessel is analyzed by using a time accurate Finite Volume solution of three dimensional incompressible Navier-Stokes equations. Computational experiments are carried out for various values of Reynolds number in order to assess the criticality of multiple mild constrictions in series and also to bring out the subtle 3D features like vortex formation. Studies reveal that pressure drop across a series of mild constrictions can get physiologically critical. Further this pressure drop is found to be sensitive to the spacing between the constrictions and also to the oscillatory nature of the inflow profile.
Porphyromonas gingivalis promotes monocyte migration by activating MMP‐9 (2011)

P. gingivalis supernatant increased the migratory ability of monocytes, in part, by increasing activation and expression of MMP-9.
Bradykinin suppresses endothelin-induced contraction of coronary artery through its B2-receptor on the endothelium. (1991)

Bradykinin (BK), a powerful vasodilating peptide, has been known to be one of the factors regulating vascular contractility mainly through its action on the endothelium. The effects of BK on vascular contraction induced by endothelin-1 (ET-1), a potent vasoconstrictor peptide produced in endothelium, were investigated in vitro using the canine coronary ringed artery. ET-1 at concentrations of 10(-10) to 10(-7) M induced strong and persistent contraction dose-dependently. The ET-1-induced contraction was inhibited by BK at concentrations of 10(-7) and 10(-6) M only in the presence of endothelium. A B1-receptor agonist (des-Arg9-BK) and a B1-receptor antagonist (des-Arg9-[Leu8]-BK) did not affect these effects of BK, whereas a B2-receptor antagonist ([D-Arg0,Hyp3,Thi5,8,D-Phe7]-BK) inhibited the effect of BK on the ET-1-induced contraction. These results indicate that BK may be a potent counter-factor for the ET-1-induced coronary vasoconstriction through its B2-receptors on the endothelium.
Supplementary Table 7 from Elevated TNFR1 and Serotonin in Bone Metastasis Are Correlated with Poor Survival following Bone Metastasis Diagnosis for Both Carcinoma and Sarcoma Primary Tumors (2023)

&lt;p&gt;PDF file - 58K, Machine learning dataset characteristics.&lt;/p&gt;
Power optimization of variable voltage core-based systems (1998)

The growing class of portable systems, such as personal computing and communication devices, has resulted in a new set of system design requirements, mainly characterized by dominant importance of power minimization and design reuse. We develop the design methodology for the low power core-based real-time system-on-chip based on dynamically variable voltage hardware. The key challenge is to develop effective scheduling techniques that treat voltage as a variable to be determined, in addition to the conventional task scheduling and allocation. Our synthesis technique also addresses the selection of the processor core and the determination of the instruction and data cache size and configuration so as to fully exploit dynamically variable voltage hardware, which result in significantly lower power consumption for a set of target applications than existing techniques. The highlight of the proposed approach is the non-preemptive scheduling heuristic which results in solutions very close to optimal ones for many test cases. The effectiveness of the approach is demonstrated on a variety of modern industrial-strength multimedia and communication applications.
Supplementary Tables from Melanoma Lesions Independently Acquire T-cell Resistance during Metastatic Latency (2023)

&lt;p&gt;Tab. S1: Genes covered in the applied sequencing Panel; Tab. S2: List of vaccine peptides&lt;/p&gt;
Optimal Adaptive Algorithms for Finding the Nearest and Farthest Point on a Parametric Black-Box Curve (2003)

We consider a general model for representing and manipulating parametric curves, in which a curve is specified by a black box mapping a parameter value between 0 and 1 to a point in Euclidean d-space. In this model, we consider the nearest-point-on-curve and farthest-point-on-curve problems: given a curve C and a point p, find a point on C nearest to p or farthest from p. In the general black-box model, no algorithm can solve these problems. Assuming a known bound on the speed of the curve (a Lipschitz condition), the answer can be estimated up to an additive error of epsilon using O(1/epsilon) samples, and this bound is tight in the worst case. However, many instances can be solved with substantially fewer samples, and we give algorithms that adapt to the inherent difficulty of the particular instance, up to a logarithmic factor. More precisely, if OPT(C,p,epsilon) is the minimum number of samples of C that every correct algorithm must perform to achieve tolerance epsilon, then our algorithm performs O(OPT(C,p,epsilon) log (epsilon^(-1)/OPT(C,p,epsilon))) samples. Furthermore, any algorithm requires Omega(k log (epsilon^(-1)/k)) samples for some instance C' with OPT(C',p,epsilon) = k; except that, for the nearest-point-on-curve problem when the distance between C and p is less than epsilon, OPT is 1 but the upper and lower bounds on the number of samples are both Theta(1/epsilon). When bounds on relative error are desired, we give algorithms that perform O(OPT log (2+(1+epsilon^(-1)) m^(-1)/OPT)) samples (where m is the exact minimum or maximum distance from p to C) and prove that Omega(OPT log (1/epsilon)) samples are necessary on some problem instances.
Development of Enhanced Rifled Tube for Vertical Water Wall Boilers (2019)

The rifled tubes which have high-cooling capability are adopted for vertical furnace water wall tubes of USC sliding pressure operation once-through boiler. To improve the boiler performance and reliability, it is effective for lowering mass velocity of furnace tube inside. In such case, rifled tubes are required to suppress the heat transfer deterioration phenomenon at supercritical pressure and also DNB (Departure from Nucleate Boiling) at subcritical pressure. In this research, we first screen and developed the rifled tube geometry by re-examining the past experimental results and performing CFD analysis. Finally, we determine new rifled tube geometry by experimental verification of its performance.
Total synthesis of (.+-.)-gephyrotoxin (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (.+-.)-gephyrotoxinRoger Fujimoto, Yoshito Kishi, and John F. BlountCite this: J. Am. Chem. Soc. 1980, 102, 23, 7154–7156Publication Date (Print):November 5, 1980Publication History Published online1 May 2002Published inissue 5 November 1980https://pubs.acs.org/doi/10.1021/ja00543a067https://doi.org/10.1021/ja00543a067research-articleACS PublicationsRequest reuse permissionsArticle Views1521Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Invited Presentation: Ionic Liquid-Based Lithium/oxygen Battery (2014)

In the last few years, much research effort is being focused on rechargeable lithium–air (O 2 ) batteries which feature a theoretical specific energy comparable to that of gasoline. While these cutting-edge batteries are at their early stage of development with many challenges to be overcome, they are the most promising candidates to power electric vehicles with long driving range. In the frame of the European LABOHR Project we are investigating the use of hydrophobic ionic liquid (IL)-based electrolytes in these batteries. Basic studies of the oxygen redox reaction in N-butyl-N-methyl pyrrolidinium bis(trifluoromethanesulfonyl)imide at home-made catalyst-free porous carbon electrode demonstrated that O 2 mass transport in IL becomes crucial at the fastest battery discharge rates, which are of interest for automotive applications. The study also demonstrated that it is possible to overcome this limitation by new flow-cell designs, and the main achievements are reported and discussed. Acknowledgement Work funded by the European Commission in the 7 th Framework Programme FP7-2010-GC-ELECTROCHEMICAL STORAGE, under contract no. 265971 “Lithium-Air Batteries with split Oxygen Harvesting and Redox processes” (LABOHR) . All the partners of the LABOHR Project are acknowledged for the fruitful discussions on Li/O 2 batteries with ionic liquids. References [1] www.labohr.eu [2] S. Monaco, A. M. Arangio, F. Soavi, M. Mastragostino, E. Paillard, S. Passerini, Electrochimica Acta 83 ( 2012 ) 94–104. [3] F. Soavi, S. Monaco, M. Mastragostino, Journal of Power Sources 224 ( 2013 ) 115 – 119. [4] S. Monaco, F. Soavi, M. Mastragostino, J. Phys. Chem. Lett. 4 ( 2013 ) 1379−1382.
Biodegradable Periodic Mesoporous Organosilica (BPMO) Loaded with Daunorubicin: A Promising Nanoparticle‐Based Anticancer Drug (2020)

Abstract Biodegradable periodic mesoporous organosilica (BPMO) nanoparticles have emerged as a promising type of nanocarrier for drug delivery, given the biodegradable feature is advantageous for clinical translation. In this paper, we report synthesis and characterization of daunorubicin (DNR) loaded BPMO. DNR was loaded onto rhodamine B‐labeled BPMO that contain tetrasulfide bonds. Tumor spheroids and chicken egg tumor models were used to characterize the activity in biological settings. In the first experiment we examined the uptake of BPMO into tumor spheroids prepared from ovarian cancer cells. BPMO were efficiently taken up into tumor spheroids and inhibited their growth. In the chicken egg tumor model, intravenous injection of DNR‐loaded BPMO led to the elimination of ovarian tumor. Lack of adverse effect on organs such as lung appears to be due to excellent tumor accumulation of BPMO. Thus, DNR‐loaded BPMO represents a promising nanodrug compared with free DNR currently used in cancer therapy. OK
Postural Disturbance in Patients with Benign Paroxysmal Positional Nystagmus (1984)

Abnormal vestibular function disrupts postural and ocular muscle control system references to gravity (earth) vertical. Vestibular disorders also prevent satisfactory resolution of normally redundant, but often conflicting, visual and somatosensory spatial references required for normal postural control during active and passive body motion. Using a moving platform and visual surrounds posturography technique to systematically interact visual, somatosensory, and vestibular inputs, it was clearly demonstrated that patients with the benign paroxysmal positional nystagmus type of distorted vestibular function employ an unstable, visually dependent postural sway distinct from the postural instability associated with unilateral or bilateral vestibular functional deficits. These findings have important clinical implications for diagnosis and management of patients with vestibular disorders.
A case of primary aldosteronism with polycystic kidney disease. (1986)

嚢胞腎を合併し,正常レニン活性値を示した原発性アルドステロン症の1例を経験した.本症例は39才,女性.主訴は高血圧,脱力感,低カリウム血症.副腎シンチグラム,副腎静脈造影,副腎静脈採血などにより,右副腎腺腫による原発性アルドステロン症と診断され,右副腎摘出術が施行された.嚢胞腎を合併していたが,腎機能障害は軽度であつた.血漿アルドステロン値が高値を示したにもかかわらず血漿レニン活性は正常範囲であつた.手術後降圧を認め,血清カリウム値も正常化したが,血漿レニン活性は高値を示した.嚢胞腎は腎不全が進展しないうちより,高頻度に高血圧を示すが,その原因の一部にレニンーアンジオテンシン系の関与するものがあると言われている.本症例の術前における血漿レニン活性が抑制されなかつた原因としては嚢胞腎の合併によるものと考えられた.
Catheter-induced mechanical conduction block of right-sided accessory fibers with Mahaim-type preexcitation to guide radiofrequency ablation. (1994)

The atrial origin of accessory connections with Mahaim-type preexcitation is apparently confined to the anterolateral-to-posterolateral region of the tricuspid annulus. Mechanical conduction block in the atrial input to the accessory fiber induced at the subannular level by catheter manipulation provides an optimal marker to locate the ablation site, even during atrial fibrillation. To expose early recurrence of antegrade accessory pathway conduction, intermittent atrial pacing in the 12 hours after ablation is advisable; in cases of recurrence, a repeat procedure can readily be performed using just the ablation catheter advanced to the target site at the tricuspid annulus.
Tracking superparamagnetic iron oxide labeled monocytes in brain by high‐field magnetic resonance imaging (2003)

Inflammatory cells, most notably mononuclear phagocytes (MP; macrophages and microglia), play a critical role in brain homeostasis, repair and disease. One important event in cellular biodynamics is how MP move in and throughout the nervous system. Prior studies have focused principally on cell migration across the blood-brain barrier during neuroinflammatory processes with little work done on cell movement within the brain. During the past decade our laboratories have studied the role of MP in HIV-1-associated dementia (HAD). In HAD MP incite sustained glial inflammatory reactions causing significant neuronal damage. To extend these works we investigated cell movement in brain and its influence for disease in a novel co-registration system integrating neuropathology with high-field magnetic resonance imaging (MRI). Human monocytes labeled with superparamagnetic iron oxide particles were injected into the brain of severe combined immunodeficient (SCID) mice. MRI was recorded 1, 7, and 14 days after cell injection. MRI co-registered with histology verified that the MRI signal modification was due to the labeled cells. MRI showed human monocyte-derived macrophages along the injection site, the corpus callosum, the ventricular system and in other brain sites. These data support the idea that cell migration can be monitored in vivo and provides an opportunity to assess monocyte mobility in brain and its affects on neurodegenerative processes and notably HAD.
Urine and stone analysis for the investigation of the renal stone former: a consensus conference (2020)

The Consensus Group deliberated on a number of questions concerning urine and stone analysis over a period of months, and then met to develop consensus. The Group concluded that analyses of urine and stones should be routine in the diagnosis and treatment of urinary stone diseases. At present, the 24-h urine is the most useful type of urine collection, and accepted methods for analysis are described. Patient education is also important for obtaining a proper urine sample. Graphical methods for reporting urine analysis results can be helpful both for the physician and for educating the patient as to proper dietary changes that could be beneficial. Proper analysis of stones is also essential for diagnosis and management of patients. The Consensus Group also agreed that research has shown that evaluation of urinary crystals could be very valuable, but the Group also recognizes that existing methods for assessment of crystalluria do not allow this to be part of stone treatment in many places.