gebhart/patrepeval huggingface dataset:
General qualitative study of point and extended defects and their interactions in non-metallic systems. Annual technical report, 1 January-31 December 1986 (1986)

This report describes progress in developing and implementing a general theoretical approach to describing the properties of defects and impurities of a general nature in nonmetallic solid systems. Also, progress in complementary nondestructive experimental tests is reviewed. These tests employ and extend newly developed techniques in EPR and NMR imaging in solids. First-of-a-kind EPR imaging experiments were performed, and a new NMR imaging laboratory was constructed.
Fibre-optic link architecture for microwave subcarriertransmission andreception (1995)

A novel fibre-optic system using subcarrier transmission and reception of microwave signals is demonstrated. Error free transmission of a 50 Mbit/s amplitude shift keyed signal over 9 and 16 GHz microwave subcarriers is demonstrated for received optical powers ≥ –30.5 and –28.5 dBm, respectively.
Gene organization of the ornithine decarboxylase-encoding region in Morganella morganii (2006)

The identification of the DNA region involved in putrescine production in M. morganii will allow additional research on their induction and regulation in order to minimize putrescine production in foods.
ZNF674: a new KRAB-containing zinc finger gene involved in non-syndromic X-linked mental retardation (2006)

Array-based comparative genomic hybridization has proven to be successful in the identification of genetic defects in disorders involving mental retardation. Here, we studied a patient with learning disabilities, retinal dystrophy, and short stature. The family history was suggestive of an X-linked contiguous gene syndrome. Hybridization of full-coverage X-chromosomal bacterial artificial chromosome arrays revealed a deletion of ∼1 Mb in Xp11.3, which harbors RP2, SLC9A7, CHST7, and two hypothetical zinc-finger genes, ZNF673 and ZNF674. These genes were analyzed in 28 families with nonsyndromic X-linked mental retardation (XLMR) that show linkage to Xp11.3; the analysis revealed a nonsense mutation, p.E118X, in the coding sequence of ZNF674 in one family. This mutation is predicted to result in a truncated protein containing the Krüppel-associated box domains but lacking the zinc-finger domains, which are crucial for DNA binding. We characterized the complete ZNF674 gene structure and subsequently tested an additional 306 patients with XLMR for mutations by direct sequencing. Two amino acid substitutions, p.T343M and p.P412L, were identified that were not found in unaffected individuals. The proline at position 412 is conserved between species and is predicted by molecular modeling to reduce the DNA-binding properties of ZNF674. The p.T343M transition is probably a polymorphism, because the homologous ZNF674 gene in chimpanzee has a methionine at that position. ZNF674 belongs to a cluster of seven highly related zinc-finger genes in Xp11, two of which (ZNF41 and ZNF81) were implicated previously in XLMR. Identification of ZNF674 as the third XLMR gene in this cluster may indicate a common role for these zinc-finger genes that is crucial to human cognitive functioning.
An asynchronous-sampling technique for the analysis of mixed signals (2003)

The paper deals with the performance evaluation of a digital method, which is based on an asynchronous sampling technique, for the analysis of bi-tone mixed signal. A deterministic and a statistical approach are proposed to study the influence of the tone frequencies, the observation interval and the sampling frequency on the behavior of the method implementation.
Properties of a human insulin receptor with a COOH-terminal truncation. I. Insulin binding, autophosphorylation, and endocytosis. (1988)

In order to test the contribution of the insulin receptor COOH terminus to insulin action, a truncation of 43 COOH-terminal amino acids was engineered by cDNA-based deletion mutagenesis. This cDNA (HIR delta CT), as well as cDNA encoding the complete receptor (HIRc) was transfected into Rat 1 fibroblasts. Cells expressing 6.4 X 10(3) and 1.25 X 10(6) normal receptors and 2.5 X 10(5) HIR delta CT receptors, as well as control Rat 1 fibroblasts were selected for further analysis. All cell lines exhibited insulin binding of similar affinity. Partial tryptic digestion and immunoprecipitation by region-specific antibodies verified that the HIR delta CT receptors were truncated at the COOH terminus. Purified HIRc and HIR delta CT receptors underwent autophosphorylation with similar insulin and ATP sensitivity, although the HIR delta CT receptors were slightly more active in the absence of insulin. Transfected HIRc and HIR delta CT receptors undergo endocytosis in a normal fashion. Insulin internalization and degradation in both HIRc and HIR delta CT cells is increased in proportion to receptor number. Intracellular insulin processing, degradation, and release were qualitatively comparable among the transfected cell lines. Complete and truncated receptors internalize, recycle, and down-regulate normally. We conclude the following: 1) the COOH-terminal portion of the insulin receptor is not necessary for partial autophosphorylation or endocytosis; 2) following internalization the intracellular itinerary of the receptor and ligand appear normal with the truncated receptor; and 3) truncation of the COOH terminus does not impair recycling of the receptor or retroendocytosis of internalized ligand.
Paper #24: Evaluation Of Current Biologic Carriers For Mesenchymal Stem Cell Application In Rotator Cuff Surgery (2013)

Differences comparing the various types of ECMs feasible for MSC application existed indicating that surgeons should be aware of the particular properties of each ECM.
ChemInform Abstract: General Sonochemical Method for the Preparation of Nanophasic Selenides: Synthesis of ZnSe Nanoparticles. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Signal transduction pathways of IL-1β-mediated iNOS in pulmonary vascular smooth muscle cells (2001)

Interleukin (IL)-1beta is an important early mediator of inflammation in pulmonary artery smooth muscle cells. We previously reported that a geranylgeranyltransferase inhibitor elevated basal levels of inducible nitric oxide synthase (iNOS) and enhanced IL-1beta-mediated induction, suggesting that Rac or Rho small G proteins are candidates for antagonism of such induction. In this study, overexpression of constitutively active Rac1 or its dominant negative mutant did not affect IL-1beta induction of iNOS. Alternatively, treatment with Clostridium botulinum C3 exoenzyme, which ADP-ribosylates Rho, was associated with superinduction of iNOS, suggesting an inhibitory role for Rho. IL-1beta activated the three mitogen-activated protein kinase (extracellular signal-regulated kinases 1 and 2, c-Jun NH2-terminal kinase/stress-activated protein kinase, and p38) and the Janus kinase (JAK)-signal transducer and activator of transcription pathways. The former two pathways were not associated with IL-1beta-mediated iNOS induction, whereas the latter two appeared to have inhibitory roles in iNOS expression. These data suggest that a broad intracellular signaling response to IL-1beta in rat pulmonary artery smooth muscle cells results in elevated levels of iNOS that is opposed by the geranylgeranylated small G protein Rho as well as the p38 and JAK2 pathways.
Long-term antibacterial surface properties of composite resin incorporating polyethyleneimine nanoparticles. (2011)

Changing the surface properties of composite resins by incorporating PEI antibacterial nanoparticles may improve their clinical performance both by inhibiting bacterial growth and by preventing changes in the surface roughness.
Cooperative Coupling of Cyanine and Tictoid Twisted π-Systems to Amplify Organic Chromophore Cubic Nonlinearities (2015)

We report a new class of hybrid π-electron chromophores with a large, sign-tunable third-order nonlinear optical (NLO) response, achieved via cooperative coupling of cyanine dye bond-length alternation effects with the rich density of states in zwitterionic twisted π-system chromophores. A combined synthetic, linear/nonlinear spectroscopic, and quantum chemical study reveals exceptional third-order response exceeding the sum of the individual chromophore contributions.
Transgenic Mice with Increased Expression of Vascular Endothelial Growth Factor in the Retina: A New Model of Intraretinal and Subretinal Neovascularization. (1998)

Okamoto, N; Tobe, T; Hackett, S F; Ozaki, H; Vinores, M A; La Rochelle, W; Zack, D J; Campochiaro, P A Author Information
Gaze Selection for Enhanced Visual Odometry During Navigation (2018)

We present an approach to enhancing visual odometry and Simultaneous Localization and Mapping (SLAM) in the context of robot navigation by actively modulating the gaze direction to enhance the quality of the odometric estimates that are returned. We focus on two quality factors: i) stability of the visual features, and ii) consistency of the visual features with respect to robot motion and the associated correspondence between frames. We assume that local texture measures are associated with underlying scene content and thus with the quality of the visual features for the associated region of the scene. Based on this assumption, we train a machine-learning system to score different regions of an image based on their texture and then guide the robot's gaze toward high scoring image regions. Our work is targeted towards motion estimation and SLAM for small, lightweight, and autonomous air vehicles where computational resources are constrained in weight, size, and power. However, we believe that our work is also applicable to other types of robotic systems. Our experimental validation consists of simulations, constrained tests, and outdoor flight experiments on an unmanned aerial vehicle. We find that modulating gaze direction can improve localization accuracy by up to 62 percent.
Ultrasensitive Electrochemical Impedance Detection of Mycoplasma agalactiae DNA by Low-Cost and Disposable Au-Decorated NiO Nanowall Electrodes (2020)

Nanostructured electrodes detecting bacteria or viruses through DNA hybridization represent a promising method, which may be useful in on-field applications where PCR-based methods are very expensive, time-consuming, and require trained personnel. Indeed, electrochemical sensors combine disposability, fast response, high sensitivity, and portability. Here, a low-cost and high-surface-area electrode, based on Au-decorated NiO nanowalls, demonstrates a highly sensitive PCR-free detection of a real sample of <i>Mycoplasma agalactiae</i> (Ma) DNA. NiO nanowalls, synthesized by aqueous methods, thermal annealing, and Au decoration, by electroless deposition, ensure a high-surface-area platform for successful immobilization of Ma thiolated probe DNA. The morphological, chemical, and electrochemical properties of the electrode were characterized, and a reproducible detection of synthetic Ma DNA was observed and investigated by impedance measurements. Electrochemical impedance spectroscopy (EIS) ascribed the origin of impedance signal to the Ma DNA hybridization with its probe immobilized onto the electrode. The electrode successfully discriminates between DNA extracted from healthy and infected sheep milk, showing the ability to detect Ma DNA in concentrations as low as 53 ± 2 copy number μL<sup>-1</sup>. The Au-decorated NiO nanowall electrode represents a promising route toward PCR-free, disposable, rapid, and molecular detection.
Search for the decay D0→π+π−μ+μ− (2013)

A search for the D 0 + - + -decay, where the muon pair does not originate from a resonance, is performed using proton-proton collision data corresponding to an integrated luminosity of 1.0 fb -1 recorded by the LHCb experiment at a centre-of-mass energy of 7 TeV. No signal is observed and an upper limit on the relative branching fraction with respect to the resonant decay mode D 0 + -( + -), under the assumption of a phase-space model, is found to be
A sustainable aqueous route to highly stable suspensions of monodispersed nano ruthenia (2011)

Highly stable suspensions of monodispersed ruthenia nanoparticles have been prepared via a sustainable aqueous oxidative pathway. The nanoparticles (2 nm) have been thoroughly characterized by TEM, XRD, XPS, MS-TGA and thermodiffraction. The addition of hydrogen peroxide in the RuCl3 solution provokes a fast oxidation of Ru(III) ions into Ru(IV). This increases the rate of the hydrolysis/condensation reactions and further promotes the nucleation over the growth of the particles. The very high stability conditions of the colloidal suspension have been studied. This aqueous one-step process, which uses no organic solvent or toxic pollutant additive, is quick and produces calibrated ruthenia nanoparticles in high yields. It presents a green alternative to the preparation and use of ruthenia. As examples, two applications are presented. In the first, RuO2 coatings have been tested for their electrical capacitance. In the second, RuO2/TiO2 catalysts, prepared from the controlled deposition of ruthenia nanoparticles on TiO2 particles, have been proven to be highly effective for the production of methane from CO2.
Room Temperature Luminescence of Silicate Sol−Gel Materials Containing Trisodium Tris(dipicolinato)neodymate(III) (1996)

Room temperature luminescence from a neodymium ion complex encapsulated in silicate sol−gel materials is observed. The organic ligand partially protects the ion and reduces radiationless deactivation. Concentration quenching is not very important in this system, but water quenching is more significant.
Ethanol vapor-mediated maturing for the enhancement of structural regularity of hexagonal mesoporous silica films (2004)

Structural regularity of hexagonal mesoporous silica films is dramatically enhanced when allowed to stand for a few hours in an ethanol vapor-containing closed bottle before dryness.
Essential Medications for Patients With Suspected or Confirmed Ebola Virus Disease in Resource-Limited Environments (2017)

Because Ebola outbreaks often occur in remote areas, proactive planning, improved preparedness, and optimal patient care for EVD are needed, especially in the context of austere environments with a scarcity of resources. We developed the EML to assist in the planning for future Ebola outbreaks in a remote clinical environment and to provide a list of medications that have been used in an ETU. The EML is a comprehensive medication list that builds on the existing publications with EVD treatment recommendations applicable to supply-constrained clinical environments. As well, it is a resource for the provision of medications when evaluating donations, procurement, and may help inform estimates for product inventory requirements for an ETU. We hope the EML will improve readiness and enhance the capabilities of local and regional international responders.
Multidisciplinary design tools for VCSEL devices and compact electronic packages (1999)

A comprehensive open environment is being developed for multi-disciplinary, multi-scale design of VCSEL devices and packages. Novel concepts of arbitrary mesh interfaces and overset Chimera grids are being developed for easy model construction and multi-scale coupling simulations. Interfaces to optical tools are also facilitated for monolithic optical and optical fiber coupling. As an example, the simulation environment has been demonstrated for analysis of thermal crosstalk in a compact proton-implanted VCSEL array package.
Indications of success: Strategies for utilizing neuroimaging biomarkers in CNS drug discovery and development (2016)

Despite large unmet medical needs in the field for several decades, CNS drug discovery and development has been largely unsuccessful. Biomarkers, particularly those utilizing neuroimaging, have played important roles in aiding CNS drug development, including dosing determination of investigational new drugs (INDs). A recent working group was organized jointly by CINP and Japanese Society of Neuropsychopharmacology (JSNP) to discuss the utility of biomarkers as tools to overcome issues of CNS drug development.The consensus statement from the working group aimed at creating more nuanced criteria for employing biomarkers as tools to overcome issues surrounding CNS drug development. To accomplish this, a reverse engineering approach was adopted, in which criteria for the utilization of biomarkers were created in response to current challenges in the processes of drug discovery and development for CNS disorders. Based on this analysis, we propose a new paradigm containing 5 distinct tiers to further clarify the use of biomarkers and establish new strategies for decision-making in the context of CNS drug development. Specifically, we discuss more rational ways to incorporate biomarker data to determine optimal dosing for INDs with novel mechanisms and targets, and propose additional categorization criteria to further the use of biomarkers in patient stratification and clinical efficacy prediction. Finally, we propose validation and development of new neuroimaging biomarkers through public-private partnerships to further facilitate drug discovery and development for CNS disorders.
Comparison of diamond-like carbon-coated nitinol stents with or without polyethylene glycol grafting and uncoated nitinol stents in a canine iliac artery model (2011)

Our findings indicate that DLC-coated nitinol stents might induce less neointimal hyperplasia than conventional nitinol stents following implantation in a canine iliac artery model; however, the DLC-coated nitinol stent surface when reformed with PEG induces more neointimal hyperplasia than either a conventional or DLC-coated nitinol stent.
Magnetic field penetration into the high temperature superconductor YBa/sub 2/Cu/sub 3/O/sub 7/minus/x/ (1988)

The penetration depth of a magnetic field into a superconducting YBa/sub 2/Cu/sub 3/O/sub 7-x/ film was measured by polarized neutron reflection. The sample comprised an epitaxial film with the c-axis of its orthorhombic structure perpendicular to the film's surface. Measurements at 14 K showed that a magnetic field (parallel to the surface) penetrates into the surface over a depth of 1400 /angstrom/. 9 refs., 3 figs.
Measuring Urban Sidewalk Practicability: a Sidewalk Robot Feasibility Index (2020)

Autonomous parcel delivery is attracting a lot of interest. Terrestrial delivery drones travel at lower speeds, are smaller and lighter than passenger cars. These features make them an ideal and valuable first step and experimental sandbox toward fully autonomous vehicles. To be useful, however, small wheeled drones need to operate on parts of the roads that are reserved to pedestrians. This is a challenge by itself. Pedestrian areas are less structured than road and abide by looser rules. The best route for a delivery drone may not be the shortest path; other aspects need to be accounted for that make a route more or less practical for the specific features of the vehicle. This paper introduces a quantitative analysis of these specific issues. The paper proposes a quantitative index that asses a route practicability for a small terrestrial drone. It combines different aspects that account for sidewalk width, sidewalk surface condition, route length and the number of driveways and crosswalks present on the way. We provide the mathematical definition of the index, and use our wheeled drone prototype to show how it can be used to classify and chose the best routes among a selection. Although the index is designed for autonomous drones, given the specific dynamic features of the drone, it can also be employed as is to quantify the accessibility of different routes for disabled people.
UDP is an antagonist at the hP2Y14 receptor (2007)

The P2Y14‐R is the eighth identified member of the P2Y‐R family of G protein‐coupled receptors (GPCRs) and is uniquely activated by nucleotide‐sugars. With the goal of developing novel high affinity ligands, we sought to identify an antagonist for the P2Y14‐R. We applied a cell‐based assay for the P2Y14‐R using a chimeric Gα subunit that allows Gαi‐coupled GPCRs to signal through phospholipase C. Uridine diphosphate (UDP) was identified as an antagonist at the hP2Y14‐R. Schild analysis confirmed the antagonism was competitive (pK B = 7.28). Antagonist activity by UDP was selective for the hP2Y14‐R among all eight human P2Y receptors. To determine whether UDP was also a competitive antagonist at other P2Y14‐R orthologs, we cloned the rat P2Y14‐R and examined the activity of UDP at this receptor. In contrast to its action at the human P2Y14‐R, UDP was a potent, full agonist at the rat P2Y14‐R with an EC50 of 0.35 μM. Discovery of high affinity ligands for the P2Y14‐R will provide important tools for expanding our knowledge of physiological roles played by this receptor.
A Soluble, Halogen-Free Oxalate from Methyl Salicylate for Chemiluminescence Demonstrations (2013)

A new oxalate ester made from methyl salicylate (oil of wintergreen) was found to be an excellent replacement for the typical halogenated oxalate ester (bis(2,4,6-trichlorophenyl) oxalate) used in peroxyoxalate chemiluminescence demonstrations. This new compound is easily prepared and has good solubility in organic solvents, such as ethyl acetate, which is an environmentally friendly solvent to use in the demonstration.
Synchronous Grammars as Tree Transducers (2004)

Tree transducer formalisms were developed in the formal language theory community as generalizations of finite-state transducers from strings to trees. Independently, synchronous tree-substitution and-adjoining grammars arose in the computational linguistics community as a means to augment strictly syntactic formalisms to provide for parallel semantics. We present the first synthesis of these two independently developed approaches to specifying tree relations, unifying their respective literatures for the first time, by using the framework of bimorphisms as the generalizing formalism in which all can be embedded. The central result is that synchronous treesubstitution grammars are equivalent to bimorphisms where the component homomorphisms are linear and complete. 1
Wind Tunnel Measurements of Non-Dimensional Lift Coefficient of a Boomerang and Comparison to Theory (2021)

View Video Presentation: https://doi.org/10.2514/6.2021-2529.vid In this paper, we measure the non-dimensional lift coefficient of a boomerang in a wind tunnel for various rotational speeds, translational speeds, and angles-of-incidence and we compare the measurements with the theoretical work of Hess, Vassberg, and Gudem. Hess’s analysis in the 1970s predicts that the non-dimensional lift coefficient is approximately proportional to the square of the non-dimensional rotational speed. Vassberg’s analysis in 2012 predicts that the non-dimensional lift coefficient is approximately proportional to a constant plus the square of the non-dimensional rotational speed. Gudem’s analysis in 2019 predicts that the non-dimensional lift coefficient is approximately linearly proportional to the non-dimensional rotational speed due to the reversal of airflow and the reversal of angle-of-attack as the blades traverse the 360 degree angles of rotation. Comparison of wind tunnel measurement results with the predictions shows that the non-dimensional lift coefficient is indeed linearly proportional to the non-dimensional rotational speed, consistent with Gudem’s theoretical predictions.