gebhart/patrepeval huggingface dataset:
Long-term outcomes to fludarabine and rituximab in Waldenström macroglobulinemia (2008)

We report the long-term outcome of a multicenter, prospective study examining fludarabine and rituximab in Waldenström macroglobulinemia (WM). WM patients with less than 2 prior therapies were eligible. Intended therapy consisted of 6 cycles (25 mg/m(2) per day for 5 days) of fludarabine and 8 infusions (375 mg/m(2) per week) of rituximab. A total of 43 patients were enrolled. Responses were: complete response (n = 2), very good partial response (n = 14), partial response (n = 21), and minor response (n = 4), for overall and major response rates of 95.3% and 86.0%, respectively. Median time to progression for all patients was 51.2 months and was longer for untreated patients (P = .017) and those achieving at least a very good partial response (P = .049). Grade 3 or higher toxicities included neutropenia (n = 27), thrombocytopenia (n = 7), and pneumonia (n = 6), including 2 patients who died of non-Pneumocystis carinii pneumonia. With a median follow-up of 40.3 months, we observed 3 cases of transformation to aggressive lymphoma and 3 cases of myelodysplastic syndrome/acute myeloid leukemia. The results of this study demonstrate that fludarabine and rituximab are highly active in WM, although short- and long-term toxicities need to be carefully weighed against other available treatment options. This study is registered at clinicaltrials.gov as NCT00020800.
Triumph and Tragedy of 21st Century Tuberculosis Drug Development (2020)

Since the discovery of the first antituberculosis drugs 75 years ago, the pursuit of a short, effective, and affordable regimen that has acceptable side effects and is capable of curing most patients most of the time has been a major public health priority. Such a “pan-tuberculosis” regimen is seen by many as essential in reducing the global tuberculosis burden.1 The successful development of two new antituberculosis drugs — bedaquiline and pretomanid — represents an important step forward in the pursuit of pan-tuberculosis regimens fit for the 21st century. Conradie and colleagues now report in the Journal that when this all-oral . . .
An Automotive Lane Guidance System (2004)

Automotive lane guidance systems, usually referred to as Lane Keeping Aid or Lane Keeping System, are designed to prevent or warn the driver of lane departure. They typically use a buzzer to alert the driver or a steering wheel torque to actually steer the vehicle back into the center of the lane. Emergency Lane Assist (ELA) combines conventional lane guidance systems with a threat assessment module that tries to activate the lane guidance interventions according to the actual risk level of lane departure. The goal is to only prevent dangerous lane departure manoeuvres.Such a threat assessment algorithm is dependent on detailed information about the vehicle surroundings, i.e., positions and motion of other vehicles, but also information about road and lane geometry parameters such as lane width and road curvature. The thesis demonstrates that the lane estimate can be improved by using an integrated ﬁlter that combines information from object and lane tracking. This is done by introducing a road aligned, curved coordinate system which also brings other advantages when it comes to modelling and prediction.Evaluation of the integrated tracking system has been carried out on real data and the ELA decision algorithm has been tested in a demonstrator. ELA successfully distinguishes between dangerous and safe lane changes ona small set of test scenarios and is, if activated, able to take control of the vehicle and put it in a safe position in the original lane.
Numerical analysis method for wireless channel of MIMO system (2005)

A numerical analysis method for the wireless channel of the multiple-input multiple-output (MIMO) system is proposed. This method is a hybrid of the finite difference time domain (FDTD) method and the method of moment (MoM), and is capable of analyzing the MIMO system including the propagation channels consisting of scatterers with arbitrary location and structure, and the transmitting and receiving antennas with arbitrary geometry. Bit error rate (BER) and channel capacities of the MIMO systems are calculated and shown by changing the received SNR, the number of antenna elements, the array spacing and the scatterers located in the propagation channel.
NOVEL MECHANISM OF CYTOMEGALOVIRUS INHIBITION BY LEFLUNOMIDE: EQUIVALENT ACTIVITY AGAINST GANCICLOVIR/FOSCARNET-SENSITIVE AND RESISTANT ISOLATES. (1998)

444 Despite substantial progress in anti-viral chemotherapy and prophylaxis, cytomegalovirus (CMV) continues to complicate the clinical course of a substantial portion of allograft recipients. Enhancement of viral activity by post-transplantation pharmacologic immune suppression engages the clinician in a constant struggle to balance graft preservation with control of CMV disease. Leflunomide, an inhibitor of protein tryrosine kinase activity and pyrimidine synthesis, is an experimental immunosuppressive agent with demonstrated effectiveness against acute and chronic rejection in animal models. Since kinase activity may be essential in viral replication, we tested the hypothesis that leflunomide might exert inhibitory activity against CMV. Plaque assays performed following inoculation of human fibroblasts or endothelial cells with each of three different clinical strains of CMV demonstrated dramatic, dose-dependent reduction in infectious virus production in the presence of A77 1726 (A77), the active metabolite of leflunomide, but not in the presence of cyclosporine A or tacrolimus. Addition of exogenous uridine restored intracellular pyrimidine nucleotide triphosphates to normal levels (as determined by HPLC), with little or no effect upon viral inhibition. Immunohistochemical staining and northern blot analysis demonstrated that neither CMV immediate early antigen nor late structural glycoprotein B expression were affected by A77, and, as determined by biochemical assay of protein extracts, CMV DNA polymerase activity was likewise unaffected. Hypothesizing that A77 might interfere with virion assembly, we showed by transmission electron microscopy that nascent virions failed to acquire tegument and external membrane in the presence of this agent. Finally, this unique mechanism of viral inhibition led us to employ plaque reduction assays to test the activity of A77 against a CMV isolate exhibiting cross resistance to ganciclovir, foscarnet, and cidofovir. Indeed this isolate exhibited sensitivity to A77 equivalent to the drug-sensitive strains. These findings, together with our previous studies, implicate leflunomide as an effective immunosuppressive agent with the potential to attenuate a major complication of immunosuppression, CMV disease, while also demonstrating a novel mechanism of anti-viral activity.
Frequency-scanning interferometry (2004)

Interferometry using a frequency scanned source offers the ability to make precision measurements of both diffuse and specular objects with large surface deviations over large fields of view. In this paper we discuss the basics of frequency-scanning interferometry and compare it to conventional laser interferometry and white-light interferometry.
Assessment of municipal solid waste for valorization into biofuels (2019)

Abstract Almost 36 million tons of paper and yard trimmings are not currently being recycled or composted annually and likely end up in landfills. One approach to valorize these resources would be for biofuels production. Nonrecyclable municipal solid waste (MSW) paper and yard trimmings were assessed for their suitability as feedstocks to produce biofuels from sugars. Both materials met the cost target of less than $85.51/ton ($2016) with MSW paper ranging from $36.40 to $62.18/dry ton and grass clippings from $25.64 to $45.86/dry ton. MSW paper exceeded the carbohydrate requirement of 59% while grass clippings had significantly lower amounts of carbohydrates (30%). However, both types of MSW had ash contents significantly above the required 5% total ash with paper at 22% ash and grass clippings at 16%. While neither waste material was individually found to be suitable for biofuels production based on compositional requirements, it was determined that blending either waste with corn stover would produce materials that met carbohydrate, ash, and cost targets. The higher carbohydrate and lower ash stover compensated for the lower carbohydrates and high ash of the waste materials, while the lower cost waste materials offset the higher cost of corn stover.
Titanosilicate zeolite precursors for highly efficient oxidation reactions (2020)

Titanosilicate zeolites are catalysts of interest in the field of fine chemicals. However, the generation and accessibility of active sites in titanosilicate materials for catalyzing reactions with large molecules is still a challenge. Herein, we prepared titanosilicate zeolite precursors with open zeolitic structures, tunable pore sizes, and controllable Si/Ti ratios through a hydrothermal crystallization strategy by using quaternary ammonium templates. A series of quaternary ammonium ions are discovered as effective organic templates. The prepared amorphous titanosilicate zeolites with some zeolite framework structural order have extra-large micropores and abundant octahedrally coordinated isolated Ti species, which lead to a superior catalytic performance in the oxidative desulfurization of dibenzothiophene (DBT) and epoxidation of cyclohexene. It is anticipated that the amorphous prezeolitic titanosilicates will benefit the catalytic conversion of bulky molecules in a wide range of reaction processes.
Antagonism of central growth hormone-releasing factor activity selectively attenuates dark-onset feeding in rats (1991)

Exogenous growth hormone-releasing factor (GRF) has been shown to activate feeding by central mechanisms involving the suprachiasmatic nucleus/medial preoptic area (SCN/MPOA). Until now, however, the role played by endogenous GRF in the SCN/MPOA in naturally occurring eating has remained unknown. To investigate this, the effects of SCN/MPOA injections of GRF antiserum (AS-GRF) on feeding in rats were studied. In light of SCN involvement in the control of circadian rhythms, AS-GRF was tested during the light and dark phases of the photoperiod. Results indicated that AS-GRF significantly attenuated dark-onset feeding but had no effect on feeding during the mid-dark, mid-light, or light-onset periods. These results suggest that endogenous GRF does play a role in naturally occurring feeding and that it may be involved in the circadian organization of feeding.
Measurement of resonant andCPcomponents inB¯s0→J/ψπ+π−decays (2014)

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Bimetallic-mediated reaction of carbon monoxide and dioxygen (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBimetallic-mediated reaction of carbon monoxide and dioxygenMitsuru Kubota, Frank S. Rosenberg, and Michael J. SailorCite this: J. Am. Chem. Soc. 1985, 107, 15, 4558–4559Publication Date (Print):July 1, 1985Publication History Published online1 May 2002Published inissue 1 July 1985https://pubs.acs.org/doi/10.1021/ja00301a038https://doi.org/10.1021/ja00301a038research-articleACS PublicationsRequest reuse permissionsArticle Views111Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mathematical modeling for vehicle dynamics, steady state cornering performance prediction using non linear tire data employing a four wheel model (2014)

An accurate full vehicle mathematical model is required to represent the vehicle behaviour in order to design its control system. The model must lead to control of crucial parameters such as yaw control, anti-roll control etc. Such a model also aids in performance prediction of the vehicle prior to building the actual prototype. This paper describes the development of a four wheel vehicle model to study the behaviour of a vehicle during steady state cornering manoeuvres. The vehicle model is designed taking into account the nonlinear tire characteristics and suspension geometry effects. A fifth order polynomial, on the basis of tire data, is constructed for the tire model. The vehicle model is then used to predict vehicle understeer / oversteer. Steering response for different vehicle configurations are computed using numerical solutions. Graphs representing understeer gradient are plotted to give a better insight to the vehicle behaviour.
Design and fabrication of multispectral optics using expanded glass map (2015)

As the desire to have compact multispectral imagers in various DoD platforms is growing, the dearth of multispectral optics is widely felt. With the limited number of material choices for optics, these multispectral imagers are often very bulky and impractical on several weight sensitive platforms. To address this issue, NRL has developed a large set of unique infrared glasses that transmit from 0.9 to &gt; 14 &mu;m in wavelength and expand the glass map for multispectral optics with refractive indices from 2.38 to 3.17. They show a large spread in dispersion (Abbe number) and offer some unique solutions for multispectral optics designs. The new NRL glasses can be easily molded and also fused together to make bonded doublets. A Zemax compatible glass file has been created and is available upon request. In this paper we present some designs, optics fabrication and imaging, all using NRL materials.
Power Efficiency and EMI Attenuation Optimization in Filter Design (2017)

This paper presents a discrete conducted electromagnetic (EM) interference filter optimization procedure, based on a genetic algorithms. A macromodeling technique taking into account the load impedance, the source emissions and the filter parasitic components, including the filter layout, is used to obtain an accurate solution for the optimization process. The latter searches among supplier passive component databases and provides, for a given filter topology, an optimal set of components available on the market. This approach has been applied to a differential Class-D audio amplifier for validation. By considering the electromagnetic interference (EMI), the additional power losses introduced by the filter and the audio gain, two different optimization formulations have been tested. The first corresponds to maximizing the power efficiency of the system while respecting a determined level of EM emissions. The second corresponds to minimizing the EMI without exceeding a determined level of power loss. The optimized filters are built and measurements are carried out. The results show a remarkable power efficiency improvement and a significant EM emission reduction when compared to a reference filter.
Performance of a turbojet combustor using natural gas fuel heated to 1200 F /922 K/ (1970)

Combustion efficiency was determined using natural gas fuel over a range of injection temperatures f r o m ambient to 1200' F (922 K).The combustor was comprised of three U-gutter flameholders mounted downstream of a trumpet-shaped diffuser in a rectangulai housing.A simple film-cooled liner was used.Tests were conducted at ambient press u r e over a range of fuel-air ratios and combustor reference velocities.Increases in efficiency of m o r e than 40 percentage points w e r e achieved at the higher fuel temperat u r e s .The results a r e applicable to natural gas afterburner design and to the design of advanced low-pressure-loss primary combustors. Security Classif. (of this page)21. No.
Nuclear receptor PXR: discovery of a pharmaceutical anti-target (2015)

Transcriptional induction of the gene encoding cytochrome P450 3A oxygenase (CYP3A) causes a prominent class of dangerous drug-drug interactions wherein one drug accelerates the metabolism of another. In our 1998 JCI paper, we reported the cloning of the human nuclear receptor PXR and demonstrated that it mediates CYP3A induction. We determined that PXR is expressed in liver, acts through a DNA response element located in the CYP3A promoter, and is activated by a structurally diverse collection of drugs that induce CYP3A. Our findings revealed the molecular basis for the CYP3A induction class of drug-drug interactions and provided a high-throughput means for screening out drug candidates with this activity.
Air Object Detection Using Pulsar FSR (2021)

One possible algorithm of signal processing for airplane detection and parameters estimation using pulsar Forward Scattering Radar (FSR) is proposed. The algorithm for air target detection proposed in the article is intended for pulsar signal processing in a pulsar FSR system. The signal source is a pulsar, the receiver is a radio telescope, and the flying object is an airplane. The pulsar signal processing algorithm consists of a direct pulsar signal compensator and a detector of forward scattering signal obtained from aircraft. The proposed algorithm was simulated in the Matlab environment using a real pulsar signal.
Roland V. Shack’s discovery of nodal aberration theory, the expansion into the aberrations of freeform optics, and impact in optical design (2020)

Freeform optics is poised to revolutionize the optical systems of our collective future, including high precision imaging systems. In this tribute paper to Roland Victor Shack, we tell the story of how Nodal Aberration Theory (NAT), invented by Shack and developed to 5th order by Kevin Paul Thompson, took on an incredible journey to become the foundation for the aberrations of freeform optics. Nodal Aberration Theory was conceived initially to understand the aberrations of misaligned optical systems. Nodal aberration theory is beautiful, as is any mathematical construct that reduces complex problems into simple formulations. The impact of moving from 100 years of design with rotationally symmetric surfaces (or sections of) into freeform optics is tremendous and opens the design space towards higher performance, more aggressive specifications in the field of view and F/#, more compact solutions, broadband solutions, and distortion-free or distortion-tailored designs.
In Situ Observation of the Emission Characteristics of Zeolite‐Hosted Silver Species During Heat Treatment (2010)

The influence of heat treatment on the evolution of luminescence in silver exchanged zeolites is investigated under controlled atmosphere by using in situ fluorescence microscopy (see figure). The results indicate that the stable yellow Ag3n+ emitter is most efficiently created in a dry zeolite Y host. In zeolite A, the clusters interact with neighboring clusters or with water, decreasing the overall yellow luminescence. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The Effect of Flooring Characteristics on Plantar Pressures on the Foot during Standing (2010)

Many studies have found that “anti-fatigue” mats reduce discomfort during prolonged standing but it is unclear why mats are successful. This has made the design and selection of effective mats difficult. An abundance of physiological evidence suggests that pressure on the foot may be a source of standing discomfort, but no research has examined pressure differences between flooring as a possible explanation for the effectiveness of mats. This experiment will measure the effect of flooring on pressures on the foot for different stance and footwear conditions. Pilot data suggest that standing barefoot, standing on a harder surface while barefoot, standing with body weight near the rear of the foot, and standing with more weight on one foot increases peak pressure. A single foot stance also results in a migration of body weight toward the rear of the foot. A larger sample size will establish whether flooring affects pressures in the shod condition, which will have an impact on future research into the relation between flooring characteristics and mechanisms for discomfort.
Electrical properties of GaN-based MIS-HEMTs with Al2O3 gate insulator deposited by ALD and mist-CVD techniques (2021)

In this work, we compare the performance of AlGaN/GaN metal-insulator-semiconductor high-electron mobility transistors (MIS-HEMTs) with gate dielectric Al2O3 prepared by either ALD or mist-CVD. While for MIS-HEMTS with ALD-Al2O3 gate insulator, the threshold voltage becomes more negative with increasing thickness of Al2O3 as expected, we found that for MIS-HEMTS with mist-Al2O3 gate insulator, the threshold voltage is anomalously almost independent of Al2O thickness. We believe that these findings have potential exciting applications for achieving normally-off operation in AlGaN/GaN MIS-HEMTs.
Robustness of practical downlink wideband CDMA channel estimation algorithms to delay estimation errors (2002)

Wideband CDMA systems employ pilot symbols for coherent detection. When the pilot symbols are time-multiplexed with data symbols, their number is usually limited, due to overhead considerations and rate matching requirements. Therefore, channel estimation based only on the pilot symbols is usually not accurate enough. It was shown previously that, in the absence of code synchronization errors, a pilot-aided decision-directed (PADD) approach exhibits better BER performance than pilot-aided estimation over fading channels, because it uses both pilot and data symbols for channel estimation. This paper shows the impact of the delay estimation errors on the PADD algorithm. The multipath delays are estimated using pilot-aided (PA), non-data aided (NDA), or decision-directed (DD) algorithms, and the comparison with ideal channel estimation case is done via simulation. The PADD algorithm in the presence of multipath delay errors is also compared with the pilot-aided plus linear interpolation channel estimation. The simulation results show that the PADD algorithm is not very sensitive to the delay estimation errors when the delays are estimated via an NDA or DD approach, and it exhibits better performance than the traditional pilot-aided methods also when the delay estimation errors are present.