gebhart/patrepeval huggingface dataset:
Fabrication issues for a chirped subwavelength form-birefringent polarization splitter (2006)

We report here on an effort to design and fabricate a polarization splitter that utilizes form-birefringence to disperse an input beam as a function of polarization content as well as wavelength spectrum. Our approach is unique in the polarization beam splitting geometry and the potential for tailoring the polarized beams' phase fronts to correct aberrations or add focusing power. A first cut design could be realized with a chirped duty cycle grating at a single etch depth. However, this approach presents a considerable fabrication obstacle since etch depths are a strong function of feature size, or grating period. We fabricated a period of 1.0 micron form-birefringent component, with a nominal depth of 1.7 microns, in GaAs using a CAIBE system with a 2-inch ion beam source diameter. The gas flows, ion energy, and sample temperature were all optimized to yield the desired etch profile.
ELAN as flexible annotation framework for sound and image processing detectors (2010)

Annotation of digital recordings in humanities research still is, to a large extend, a process that is performed manually. This paper describes the first pattern recognition based software components developed in the AVATecH project and their integration in the annotation tool ELAN. AVATecH (Advancing Video/Audio Technology in Humanities Research) is a project that involves two Max Planck Institutes (Max Planck Institute for Psycholinguistics, Nijmegen, Max Planck Institute for Social Anthropology, Halle) and two Fraunhofer Institutes (Fraunhofer-Institut für Intelligente Analyse- und Informationssysteme IAIS, Sankt Augustin, Fraunhofer Heinrich-Hertz-Institute, Berlin) and that aims to develop and implement audio and video technology for semi-automatic annotation of heterogeneous media collections as they occur in multimedia based research. The highly diverse nature of the digital recordings stored in the archives of both Max Planck Institutes, poses a huge challenge to most of the existing pattern recognition solutions and is a motivation to make such technology available to researchers in the humanities.
Abstract 4434: 12 Months and Beyond: Long-Term Results of the Direct Flow Medical Repositionable and Retrievable Pericardial Valve for Percutaneous Aortic Valve Replacement (2009)

Background Percutaneous aortic valve replacement is considered an alternative for patients at high risk for open surgical repair. The Direct Flow Medical (Santa Rosa, CA) Percutaneous Aortic Valve ...
[Studies on coagulation-fibrinolytic system in diabetic nephropathy--with reference to plasma TAT and alpha 2PIC]. (1990)

Coagulation-fibrinolytic system is known to be one of the exacerbating factors in patients with diabetic nephropathy. The aim of the present study was to evaluate whether coagulation-fibrinolytic system in patients with diabetic nephropathy were significantly correlated with the development of this disease using new parameters of plasma thrombin antithrombin III complex (TAT) and plasmin alpha 2 plasmin inhibitor complex (alpha 2PIC). Fifty-six patients with NIDDM were examined. None of these patients showed more than 1.3 mg/dl of serum creatinine levels. These patients were divided into three groups according to the levels of albumin creatinine ratio (ACR) in urine as follows: 1) group I had ACR of less than 30 mg/g.Cr; 2) group II had ACR of greater than 30 mg/g.Cr and less than 100 mg/g.Cr; 3) group III had ACR of greater than 100 mg/g.Cr. Correlations of levels of plasma TAT and alpha 2PIC, levels of HbAlc, duration of diabetes, and presence of retinopathy were determined in these groups. The levels of plasma TAT and alpha 2PIC increased as the levels of urinary ACR increased regardless of presence of retinopathy. The levels of TAT and alpha 2PIC with retinopathy increased compared with those without retinopathy. There was a significantly positive correlation between plasma TAT and alpha 2PIC (r = 0.52, p less than 0.01). The levels of HbAlc and duration of diabetes did not significantly correlate to plasma TAT and alpha 2PIC. These data suggest that the existence of increase in coagulation-fibrinolytic system seem to be one of the exacerbating factors in patients with diabetic nephropathy.(ABSTRACT TRUNCATED AT 250 WORDS)
Induction of Bax and activation of caspases during beta-sitosterol-mediated apoptosis in human colon cancer cells. (2003)

beta-sitosterol, a main dietary phytosterol found in plants, may have the potential for prevention and therapy for human cancer. The purpose of the present study was to examine the effect of beta-sitosterol on the growth of HT116 human colon cancer cells. Treatment with beta-sitosterol resulted in a dose-dependent growth inhibition coupled with the characteristic morphological features of apoptosis and with the increase of a sub-G1 cell population. Apoptosis-inducing concentrations of beta-sitosterol induced caspase-3 and caspase-9 activation accompanied by proteolytic cleavage of poly(ADP-ribose)-polymerase. In addition, beta-sitosterol-induced apoptosis in HT116 cells was associated with a decreased expression of the anti-apototic Bcl-2 protein and mRNA and a concomitant increase of the pro-apototic Bax protein and mRNA, and with release of cytochrome c from the mitochondria into the cytosol. beta-sitosterol treatment also inhibited the expression of cIAP-1 without significant changes in the level of cIAP-2. Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of beta-sitosterol.
Large scale isolation of expression vector cassette by magnetic triple helix affinity capture (1995)

Journal Article Large scale isolation of expression vector cassette by magnetic triple helix affinity capture Get access Srinivas V. Sonti, Srinivas V. Sonti Search for other works by this author on: Oxford Academic PubMed Google Scholar Matthew C. Griffor, Matthew C. Griffor 3Dekalb Genetics Corp.62 Maritime Drive, Mystic, CT 06355-1958, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Takeshi Sano, Takeshi Sano 1Center for Advanced Biotechnology36 Cummington Street, Boston University, Boston, MA 02215, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Sandya Narayanswami, Sandya Narayanswami 2The Jackson LaboratoryMain Street, Bar Harbor, ME 04609, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Arijit Bose, Arijit Bose Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles R. Cantor, Charles R. Cantor 1Center for Advanced Biotechnology36 Cummington Street, Boston University, Boston, MA 02215, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Albert P. Kausch Albert P. Kausch * 3Dekalb Genetics Corp.62 Maritime Drive, Mystic, CT 06355-1958, USA * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 23, Issue 19, 11 October 1995, Pages 3995–3996, https://doi.org/10.1093/nar/23.19.3995 Published: 11 October 1995 Article history Received: 31 August 1995 Accepted: 31 August 1995 Published: 11 October 1995
Multilayer stacked white polymer light-emitting diodes (2009)

Multilayer stacked white polymer light-emitting diodes (WPLEDs) with a multilayer emitting structure were produced using a stamp transfer printing process. Two light-emitting layers were stacked using a transfer printing method, and the device performance of the WPLEDs was examined. Yellow light-emitting polymers spin coated onto silicone substrates were transferred to a polydimethylsiloxane stamp, which was transferred effectively to the top of blue polymers. White colour coordinates of (0.34, 0.41) were obtained from the multilayer stacked WPLEDs.
Stromal Vascular Fraction Vasculogenesis, Vessel Incorporation, and Integration with Intact Angiogenic Microvascular Networks in an Ex Vivo Cultured Tissue Model (2019)

Angiogenesis, the growth of new vessels from pre‐existing vessels, is vital to wound healing in the cases of myocardial infarction and peripheral arterial disease. Adipose‐derived stromal vascular fraction (SVF), consisting of endothelial cells, endothelial progenitor cells, pericytes, smooth muscle cells, fibroblasts and immune cells, can be transplanted to assist in wound healing as seen in various clinical trials. However, the spatiotemporal incorporation of the SVF within living tissues remains largely unknown. As such, understanding where and how SVF cells contribute to microvascular growth and remodeling will help guide their therapeutic use. The objective of this study was to evaluate the impact of SVF cells and their fate during microvascular growth utilizing a novel tissue culture model that enables time‐lapse observation of cell dynamics across intact networks. SVF was isolated from adipose of an adult male Wistar rat, labeled with DiI, and seeded onto mesentery tissues harvested from the same rat before culturing in MEM + 10% fetal bovine serum and 1% PenStrep for 3 days. Tissues were then labeled for lectin to identify vessels. Alternatively, SVF was isolated from adipose harvested from adult male or female SD‐EGFP rats, seeded onto lectin labeled mesentery from adult male Wistar rats, placed under the same culture conditions, and imaged every 24 hours. Vascularized area was increased in SVF treated versus control tissues (SVF = 84.5±1.3%; Control = 56.5%; p &lt; 0.001; n = 4 tissues per group). The SVF related microvasculature was characterized by asterisk‐shaped clusters. GFP tracking of SVF revealed vessel segment formation via vasculogenesis containing endothelial cells and pericytes in previously avascular areas. In pre‐vascularized regions, SVF cells contributed to new vessel growth and integration with and along native vessels. SVF cells were observed both in apparent endothelial cell and wrapping pericyte locations. Interestingly, examples of new vessel segments derived from SVF cells were observed along LYVE‐1 positive lymphatic vessels. These results suggest that SVF transplantation increases vascular area through vasculogenesis and contributes to angiogenesis of pre‐existing vasculature. The results also support the use of the rat mesentery culture model as a novel tool for elucidating SVF cell transplant dynamics in an intact tissue environment. Support or Funding Information Funded by NIH R01AG049821 This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
The functional CD40 antigen of fibroblasts may contribute to the proliferation of rheumatoid synovium (1996)

This paper demonstrates that CD40 is expressed on rheumatoid synovial pannus and primary fibroblast cell lines established from rheumatoid and osteoarthritic synovium as well as normal skin. Among various tested cytokines, interferon-gamma (IFN-gamma) and to a lower extent, tumour necrosis factor-alpha (TNF-alpha) were found to upregulate CD40 expression on fibroblasts. Synovial and skin fibroblasts cultured over CD40 Ligand transfected L cells (L-CD40 L) demonstrate a CD40 specific increase of DNA synthesis as measured by tritiated thymidine incorporation. Cell-cycle analysis and enumeration of viable cells further show that CD40 induced fibroblast proliferation. Costimulation with L-CD40 L and IFN-gamma resulted in maximal proliferation. Engagement of fibroblasts CD40 increased the IL-1-induced production of granulocyte macrophage-colony stimulating factor and macrophage inflammatory protein-1 alpha MIP-1 alpha. CD40 L activated fibroblasts showed decreased levels of CD40, but only marginal alterations of other cell-surface antigens. Taken together, the present results indicate that fibroblasts express functional CD40 and suggest a possible role of CD40 L expressing cells, such as activated T cells and mast cells, in the development of synovium hyperplasia.
Theoretical Calculation of the Optical Anisotropy of Substituted Cyclohexanes and Associated Bisphenyl Molecules Using Experimentally Derived Group Polarizabilities (2002)

A general method for the formulation of polarizability tensor and computation of optical anisotropy of a series of substituted cyclohexanes and their bisphenyl fragments, which are model analogues of corresponding polymers is presented. The calculation makes use of the molecular geometry and conformations from force-field simulations and the anisotropic polarizability tensors of the constituent groups derived from experiments reported in the literature. Cyclohexanes with phenyl group substitution show higher anisotropy than those with methyl substituents. For the same substitution, a higher optical anisotropy is observed for equatorial orientation than axial. The optical anisotropy for the cyclohexanes is dependent on the orientation of the substituent group rather than on its position, whereas for the bisphenyl fragments the anisotropy is dependent on both these factors along with the conformation of the whole molecule. All the cyclohexyl substituted bisphenyl fragments show lower optical anisotropy than diphenylpropane, a model analogue of bisphenol A polycarbonate that is widely used in optical applications. The results presented here have implications and potential applications in the design of molecules as well as polymers for optical media.
Conformational Analysis of Model Complexes for Methyl‐Coenzyme‐M Reductase from Methanogenic Bacteria: A Comparison of Crystal and Solution Structures (1993)

Do predictions based on crystal structure data hold for conformers in solution? This question was asked in studies of the NiII model complexes rac-1–rac-3 by NMR spectroscopy and X-ray structure analysis. The result—drastically different distributions of conformers in solution and in the solid state—may contribute to the current understanding of the mechanism of action of the nickel-containing enzyme methyl-coenzyme-M reductase.
ChemInform Abstract: DILITHIUM SEMIBULLVALENIDE: AN UNUSUAL ORGANOLITHIUM COMPOUND EXTENDS THE SCOPE OF HOMOAROMATICITY (1982)

Abstract Das Dianion, das aus der Reduktion von Semibullvalen (I) bei ‐78°C hervorgeht, weist °Li‐, 1 H‐ und 13 C‐NMR‐Spektren auf, die einer Racemi‐ sierung der Di ‐ Li‐Derivate entsprechen.
Cavity Filling Analysis and Design (2022)

No AccessInjection Mold Design EngineeringOct 2022Cavity Filling Analysis and DesignDavid O. KazmerDavid O. Kazmerhttps://doi.org/10.3139/9781569908921.005SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2022Pages: 137-173Print ISBN: 978-1-56990-891-4eISBN: 978-1-56990-892-1 Copyright & Permissions© 2022 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Inactivated hepatitis A vaccine in Chinese patients with chronic hepatitis B infection (1999)

The HAV vaccine is equally efficacious in patients with chronic HBV infection.
Frontend light source for short-pulse pumped OPCPA system (2009)

We present the development of a light source for generating optically synchronized seed pulses both for the parametric amplifier chain and the pump-laser chain of the Petawatt Field Synthesizer (PFS), which is currently under construction at MPQ. The PFS system aims at delivering waveform-controlled few-cycle laser pulses with PW-scale peak power using optical parametric chirped pulse amplification (OPCPA). Methods of generating the broadband near-infrared (NIR) seed pulses for the OPCPA chain by spectral broadening using few-cycle pulses are presented. We also demonstrate the generation of a supercontinuum spanning up to three octaves (270–1500 nm) using cascaded hollow-core fibers which supports sub-cycle pulse duration.
Theoretical Investigation of Six-Mode Multi/Demultiplexer Based on Fused-Type Multicore Fiber Coupler (2016)

A six-mode (LP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">01</sub> /LP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sub> ab/LP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">21ab</sub> /LP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">02</sub> ) multi/demultiplexer based on a fused-type multicore fiber coupler is proposed, and the coupling characteristics are investigated. The multi/demultiplex operation is achieved by a phase matching between the desired mode of center core and the LP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">01</sub> mode of the outer core in the elongated region of the fused-type multicore fiber coupler. From the numerical results based on the beam propagation method, it is found that the coupling efficiencies between the LP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">01</sub> and LP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sub> /LP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">21</sub> /LP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">02</sub> modes are more than -0.1 dB, and the crosstalk is lower than -20 dB at the wavelength of 1550 nm.
A Study on the Preferred Level of Late Reverberation in Speech and Music (2016)

S.29-34
First human dose escalation study in patients with metastatic malignancies to determine safety and pharmacokinetics of LY2157299, a small molecule inhibitor of the transforming growth factor-beta receptor I kinase (2008)

14554 Background: Transforming Growth Factor beta (TGF-β) is an important cytokine regulating physiological processes, such as neoangiogenesis, immune responses and tissue remodeling. LY2157299 is a novel small molecule inhibitor which selectively targets the kinase domain of the TGF-β receptor type I. Methods: Patients with advanced/metastatic malignancies and who had exhausted all approved treatments were enrolled in this study. A pharmacokinetic/pharmacodynamic (PK/PD) model was developed based on pre-clinical studies to define starting doses and dose selection for this First Human Dose (FHD) study. Cohorts of 3 patients each were used to determine the safety and pharmacokinetics at the daily doses of 40 mg and 80 mg. Results: Seven patients (3 and 4 patients at the 40 mg and 80 mg dose, respectively) were enrolled in this study, who had colon cancer (n=3), prostate cancer (n=1), adrenal gland cancer (n=1), breast cancer (n=1) and melanoma (n=1). LY2157299 was well tolerated at both doses of 40 and 80 mg and no drug-related CTCAE Grade 3 or 4 toxicities were observed. The PK profile was consistent with the preclinical-based PK/PD modeling. Analysis of the 2 cohorts showed that absorption of LY2157299 was rapid as determined by plasma concentrations at the first sampling time (0.5 hours). The apparent clearance (CL/F) and the apparent volume of distribution (V/F) were estimated at 27.9L/h and 146.4L, respectively. Results from a formal statistical analysis suggested dose proportionality based on the observed AUC (0–12) and Cmax across the two doses. The mean t1/2 remained relatively constant and was estimated to be 6.5 hours. No definitive accumulation of LY2157299 was observed over the 56-day BID dosing regimen. Within and between patient coefficients of variation were 29% and 49% for AUC (0–12), respectively, and 33% and 78% for Cmax/Cmax,ss, pooled across the 2 cohorts. Conclusions: Daily oral administration of LY2157299 was safe and well tolerated at the two dose levels and the pharmacokinetic profile was consistent with the prediction derived from preclinical PK/PD model. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Eli Lilly Eli Lilly
Acoustic Indicators for Targeted Detection of Stored Product and Urban Insect Pests by Inexpensive Infrared, Acoustic, and Vibrational Detection of Movement (2010)

Crawling and scraping activity of three stored-product pests, Sitophilus oryzae (L.) (Coleoptera: Curculionidae), Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae), and Stegobium paniceum (L.) (Coleoptera: Anobiidae), and two urban pests, Blattella germanica (L.) (Blattodea: Blattellidae) and Cimex lectularius L. (Hemiptera: Cimicidae), were monitored individually by infrared sensors, microphones, and a piezoelectric sensor in a small arena to evaluate effects of insect locomotory behavior and size on the ability of an inexpensively constructed instrument to detect insects and distinguish among different species. Adults of all species could be detected when crawling or scraping. The smallest insects in the study, first-fourth-instar C. lectularius nymphs, could not be detected easily when crawling, but could be detected when scraping. Sound and vibration sensors detected brief, 3-10-ms impulses from all tested species, often grouped in distinctive trains (bursts), typical of impulses in previous acoustic detection experiments. To consider the potential for targeting or focusing detection on particular species of interest, indicators were developed to assess the likelihood of detection of C. lectularius. Statistically significant differences were found between C. lectularius and other species in distributions of three measured variables: infrared signal durations, sound impulse-burst durations, and sound pressure levels (energy) of impulses that best matched an averaged spectrum (profile) of scraping behavior. Thus, there is potential that signals collected by an inexpensive, polymodal-sensor instrument could be used in automated trapping systems to detect a targeted species, 0.1 mg or larger, in environments where servicing of traps is difficult or when timeliness of trapping information is important.
Study on micro-fabrication processes in CoFeB/MgO/CoFeB magnetic tunnel junctions (2005)

The effect of reactive ion etching (RIE) micro-fabrication process using methanol (CH/sub 3/OH) gas on the magnetoresistance properties of CoFeB/MgO/CoFeB magnetic tunnel junctions (MTJs) was investigated in this paper. The result has been compared with that of the MTJs etched with ion-milling method.
Variability analysis for sub-100 nm PD/SOI CMOS SRAM cell (2004)

We have studied the impacts of floating body effect, device leakage, and gate oxide tunneling leakage on the read and write stability of a PD/SOI CMOS SRAM cell under Vt, L and W variations in sub-100 nm technology for the first time. The floating body effect is shown to degrade the read stability while improving the write stability. On the other hand, the gate-to-body tunneling current improves the read stability while degrading the write stability. It is also shown that the use of high-Vt cell transistors can improve the read and write stability without causing significant performance degradation.
Bright Light Induces Mitochondrial Fission in Photoreceptors: Implications in Retinal Degeneration (2005)

Extract HTML view is not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button. Extended abstract of a paper presented at Microscopy and Microanalysis 2005 in Honolulu, Hawaii, USA, July 31--August 4, 2005