gebhart/patrepeval huggingface dataset:
Neutrophil mediated drug delivery for targeted glioblastoma therapy: A comprehensive review (2022)

Glioblastoma is the most common brain cancer in adults and presents a major challenge for targeted drug delivery due to the blood-brain barrier (BBB) and the highly infiltrative growth of the glioma cells into the brain. Cell-mediated drug-delivery systems have been proposed as a potential strategy to enhance the effects of drugs and reduce their side effects in the treatment of cancer. Neutrophils are the most abundant type of WBC in humans and can overcome impermeable barriers and transport drugs into inflamed sites such as tumors. Therefore, a promising approach for an innovative drug delivery system is the use of neutrophils as Trojan horses for drug delivery. However, compared to other leukocytes such as macrophages, little is known about how human neutrophils respond to and take up synthetic particles. In this review, we summarize the factors affecting the uptake of nanoparticles (NPs) by neutrophils, as well as recent advances and challenges related to the interaction between neutrophils and NPs, with particular emphasis on the interaction of magnetic mesoporous silica NPs, liposomes, albumin NPs, and PLGA NPs with neutrophils. Finally, the potential application of neutrophil-based drug delivery systems for the prevention of glioblastoma recurrence and also the potential application of neutrophil-mimicking nanoparticles (NM-NPs) in glioblastoma therapy are discussed.
Adaptive Regularization of Ill-Posed Problems: Application to Non-rigid Image Registration (2009)

We introduce an adaptive regularization approach. In contrast to conventional Tikhonov regularization, which specifies a fixed regularization operator, we estimate it simultaneously with parameters. From a Bayesian perspective we estimate the prior distribution on parameters assuming that it is close to some given model distribution. We constrain the prior distribution to be a Gauss-Markov random field (GMRF), which allows us to solve for the prior distribution analytically and provides a fast optimization algorithm. We apply our approach to non-rigid image registration to estimate the spatial transformation between two images. Our evaluation shows that the adaptive regularization approach significantly outperforms standard variational methods.
Order, disorder, and fluctuation effects in an asymmetric poly(ethylene-propylene)-poly(ethylethylene) diblock copolymer (1992)

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Effects of a ZnCuO-Nanocoated Ti-6Al-4V Surface on Bacterial and Host Cells (2022)

This study aims to investigate the effects of a novel ZnCuO nanoparticle coating for dental implants-versus those of conventional titanium surfaces-on bacteria and host cells. A multispecies biofilm composed of <i>Streptococcus sanguinis</i>, <i>Actinomyces naeslundii</i>, <i>Porphyromonas gingivalis</i>, and <i>Fusobacterium nucleatum</i> was grown for 14 days on various titanium discs: machined, sandblasted, sandblasted and acid-etched (SLA), ZnCuO-coated, and hydroxyapatite discs. Bacterial species were quantified with qPCR, and their viability was examined via confocal microscopy. Osteoblast-like and macrophage-like cells grown on the various discs for 48 h were examined for proliferation using an XTT assay, and for activity using ALP and TNF-α assays. The CSLM revealed more dead bacteria in biofilms grown on titanium than on hydroxyapatite, and less on sandblasted than on machined and ZnCuO-coated surfaces, with the latter showing a significant decrease in all four biofilm species. The osteoblast-like cells showed increased proliferation on all of the titanium surfaces, with higher activity on the ZnCuO-coated and sandblasted discs. The macrophage-like cells showed higher proliferation on the hydroxyapatite and sandblasted discs, and lower activity on the SLA and ZnCuO-coated discs. The ZnCuO-coated titanium has anti-biofilm characteristics with desired effects on host cells, thus representing a promising candidate in the complex battle against peri-implantitis.
Oxygen-Stable Hemolysins of Group A Streptococci VIII. Leukotoxic and Antiphagocytic Effects of Streptolysins S and O (1972)

Streptolysin S exists in a cell-bound form and as an extracellular complex between a nonspecific carrier (serum, serum albumin, ribonucleic acid [RNA], Triton, Tween) and a hemolytic moiety (probably a peptide) synthesized by streptococci. Although all the forms of streptolysin S, at 100 hemolytic units, killed mouse leukocyte monolayers, the time needed to kill 100% of the cells varied with the different streptolysin S preparations. Whereas 30 min was sufficient for the cell-bound hemolysin to kill all of the cells, 60 and 180 min were required when RNA streptolysin S and serum streptolysin S, respectively, were employed. Addition of 10% mouse serum to RNA streptolysin S or to cell-bound hemolysin delayed the killing of the leukocytes. The delayed killing observed with serum and albumin hemolysins is probably due to competition for the hemolytic moiety between the carrier molecules and target sites (phospholipids) upon the leukocyte membrane. Serum streptolysin S must be constantly incubated with the cells for 90 min for 100% of the cells to undergo cytopathic changes upon subsequent incubation for an additional 90 min. Streptolysin S inhibitor (trypan blue) added to the system after 30 or 60 min of incubation resulted in the killing of 50 and 100% of the leukocytes, respectively, when the cells were further incubated for 120 min. It is suggested that 30 min of incubation was not sufficient for the transfer of enough streptolysin S molecules upon the cell surface to allow killing of all of the cells. Sublethal amounts of streptolysin S, streptolysin O, and saponin suppressed phagocytosis of streptococci by mouse peritoneal macrophages. This effect was abolished by inhibitors of streptolysin S (trypan blue) and of streptolysin O and saponin (cholesterol). With sublethal amounts of streptolysin S, no inhibition of the reduction of nitro blue tetrazolium by nonphagocytosing cells was observed, but these amounts of streptolysin S caused a 50% inhibition of the reduction of nitro blue tetrazolium by phagocytosing leukocytes. It is suggested that some metabolic systems, which are normally enhanced during phagocytosis, have been affected by sublethal doses of streptolysin S. The results indicate that the in vivo production of small amounts of streptolysins S and O by group A streptococci may inhibit phagocytosis and may thus contribute to the invasiveness and pathogenicity of this microorganism.
Probing hydrogen-bonding patterns in cocrystals of amides and triarylphosphine oxides using high-resolution solid-state 31P NMR spectroscopy (1992)

The isotropic 31P chemical shift for hydrogen-bonded cocrystals formed between aryl sulfonamides and triarylphosphine oxides shows a linear corrleation with the number of hydrogen-bonds, N–H ⋯ O–P, formed by each triarylphosphine oxide fragment; this result can now be applied as a means of deriving information on the hydrogen-bonding patterns in related cocrystals of unknown structure.
Gastro‐duodenal digestion products of the major peanut allergen Ara h 1 retain an allergenic potential (2006)

Gastro-duodenal digestion fragments of Ara h 1 retain T cell stimulatory and IgE-binding and cross-linking properties of the intact protein.
Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis (2017)

By causing mitochondrial DNA (mtDNA) mutations and oxidation of mitochondrial proteins, reactive oxygen species (ROS) leads to perturbations in mitochondrial proteostasis. Several studies have linked mtDNA mutations to metastasis of cancer cells but the nature of the mtDNA species involved remains unclear. Our data suggests that no common mtDNA mutation identifies metastatic cells; rather the metastatic potential of several ROS-generating mutations is largely determined by their mtDNA genomic landscapes, which can act either as an enhancer or repressor of metastasis. However, mtDNA landscapes of all metastatic cells are characterized by activation of the SIRT/FOXO/SOD2 axis of the mitochondrial unfolded protein response (UPR<sup>mt</sup>). The UPR<sup>mt</sup> promotes a complex transcription program ultimately increasing mitochondrial integrity and fitness in response to oxidative proteotoxic stress. Using SOD2 as a surrogate marker of the UPR<sup>mt</sup>, we found that in primary breast cancers, SOD2 is significantly increased in metastatic lesions. We propose that the ability of selected mtDNA species to activate the UPR<sup>mt</sup> is a process that is exploited by cancer cells to maintain mitochondrial fitness and facilitate metastasis.
Vascular Protection and Decongestion Without Renin–Angiotensin–Aldosterone System Stimulation Mediated by a Novel Dual-Acting Vasopressin V1a/V2 Receptor Antagonist (2019)

Increased plasma vasopressin levels have been shown to be associated with the progression of congestive heart failure. Vasopressin mediates water retention by renal tubular V2 receptor activation as well as vasoconstriction, cardiac hypertrophy, and fibrosis through V1a receptor activation. Therefore, we developed a novel, dual-acting vasopressin receptor antagonist, BAY 1753011, with almost identical Ki-values of 0.5 nM at the human V1a receptor and 0.6 nM at the human V2 receptor as determined in radioactive binding assays. Renal V2 antagonism by BAY 1753011 was compared with the loop diuretic furosemide in acute diuresis experiments in conscious rats. Similar diuretic efficacy was found with 300-mg/kg furosemide (maximal diuretic response) and 0.1-mg/kg BAY 1753011. Furosemide dose-dependently induced plasma renin and angiotensin I levels, while an equiefficient diuretic BAY 1753011 dose did not activate the renin-angiotensin system. BAY 1753011 dose-dependently decreased the vasopressin-induced expression of the profibrotic/hypertrophic marker plasminogen activator inhibitor-1 and osteopontin in rat cardiomyocytes, while the selective V2 antagonist satavaptan was without any effect. The combined vascular V1a-mediated and renal V2-mediated properties as well as the antihypertrophic/antifibrotic activity enable BAY 1753011 to become a viable treatment option for oral chronic treatment of congestive heart failure.
Microstructure of Polycrystalline PBTTT Films: Domain Mapping and Structure Formation (2012)

We utilize near-edge X-ray absorption fine structure (NEXAFS) spectroscopy and scanning transmission X-ray microscopy (STXM) to study the microstructure and domain structure of polycrystalline films of the semiconducting polymer poly(2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene) (PBTTT). Total electron yield NEXAFS spectroscopy is used to examine the surface structure of the first 1-2 molecular layers, while bulk-sensitive STXM is used to produce maps of domain orientation and order sampled through the entire film thickness. We study different phases of PBTTT including as-cast, terraced and nanoribbon morphologies produced via spin-coating as well as aligned films of as-cast and nanoribbon morphologies produced by zone-casting. For the terraced morphology, domains are observed that are larger than the size of the terraced surface features, and the calculated degree of order is reduced compared to the nanoribbon morphology. For zone-cast films, we find that, although little optical anisotropy is observed in the bulk of as-cast films, a high degree of surface structural anisotropy is observed with NEXAFS spectroscopy, similar to what is observed in annealed nanoribbon films. This observation indicates that the aligned surface structure in unannealed zone-cast films templates the bulk ordering of the aligned nanoribbon phase. STXM domain mapping of aligned nanoribbon films reveals elongated, micrometer-wide domains with each domain misoriented with respect to its neighbor by up to 45°, but with broad domain boundaries. Within each nanoribbon domain, a high degree of X-ray dichroism is observed, indicating correlated ordering throughout the bulk of the film.
Additional file 11: of Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus (2017)

Orthology analysis of CAZy genes related to plant biomass degradation. (XLSX 148 kb)
Supplementary information from Genomic Landscape Established by Allelic Imbalance in the Cancerization Field of a Normal Appearing Airway (2023)

&lt;p&gt;Supplementary information including supplementary methods, supplementary tables and figures as well as supplementary figure legends. Supplementary Figure 1. HapLOH results for matched normal large airway and NSCLC tumor from case 18 Supplementary Figure 2. Distribution of posterior probabilities for airway events called by hapLOH Supplementary Figure 3: Allelic imbalance events detected in normal-appearing airway brushings Supplementary Figure 4. Event classification using B-allele frequencies and log R ratios Supplementary Figure 5. Effect of allelic imbalance on B-allele frequencies Supplementary Figure 6: Distribution of focal and arm airway events&lt;/p&gt;
ChemInform Abstract: ANTIBIOTICS FROM BASIDIOMYCETES, XIX. NAEMATOLIN AND NAEMATOLONE, TWO CARYOPHYLLANE DERIVATIVES FROM CULTURES OF HYPHOLOMA SPECIES (AGARICALES) (1984)

Abstract Aus den Kulturfiltraten verschiedener Hypholoma‐Arten werden Naematolin (Ia) und Naemotolon (II) isoliert, deren Strukturen über die Derivate (Ib) bis (Id) und durch die spektroskopischen Daten ermittelt werden.
Multifunctional Heterogeneous Catalysts: SBA‐15‐Containing Primary Amines and Sulfonic Acids (2006)

Doppelfunktion: Die Immobilisierung von primären Aminen und Sulfonsäuren auf mesoporösem Siliciumdioxid (SBA-15-A/B; siehe Schema) ergibt einen kooperativen Heterogenkatalysator für Aldolkondensationen. Die chemischen Reaktivitäten der sauren und basischen Gruppen bleiben jeweils erhalten, ohne sich, wie in homogener Lösung, zu neutralisieren. TEOS: Tetraethoxysilan. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2006/z602243_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
DETRUSOR OVERACTIVITY PRESSURE AND MIDURETHRAL SLING OUTCOMES (2009)

This document has been archived because it contains outdated information. It should not be consulted for clinical use, but for historical research only. Please visit the journal website for the most recent guidelines.
ChemInform Abstract: AMP Deaminase Inhibitors. Part 2. Initial Discovery of a Non‐Nucleotide Transition‐State Inhibitor Series. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A novel synthesis of chitosan nanoparticles in reverse emulsion (2008)

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Observations of heterogeneous nucleation of water vapor on a cold substrate. (1992)

The appearance of liquid or solid condensates from water vapor on a cold substrate was observed and the critical supersaturation ratios required for heterogeneous nucleation were determined
Supplementary Figure S5 from Leukemia Cell-Rhabdovirus Vaccine: Personalized Immunotherapy for Acute Lymphoblastic Leukemia (2023)

&lt;p&gt;Supplementary Figure S5 - PDF file 1161K, iLOV induces leukemia-specific immunity&lt;/p&gt;
Lithium Halides, Lithium Cyanide, and Related Salts (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
La tabla periódica de EuChemS. La tabla que resalta la escasez y disponibilidad de los elementos químicos naturales (2019)

El ano 2019 ha sido declarado por la Asamblea General de las Naciones Unidas como el Ano Internacional de laTabla Periodica de los Elementos Quimicos (IYPT2019, en sus siglas inglesas).
Cyclobutane Derivatives as Potent NK1 Selective Antagonists. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Qualification testing of the ZTJ GaInP<inf>2</inf>/GaInAs/Ge solar cell to the AIAA S-111 standard (2009)

We report the results to date of qualification testing of Emcore's sixth generation III-V multi-junction solar cell - the ZTJ GaInP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Ga(In)As/Ge cell. The ZTJ cell is currently undergoing space qualification per the requirements of the American Institute of Aeronautics and Astronautics (AIAA) S-111-2005 standard. The S-111 document consists of a comprehensive set of qualification tests, which include front/backside weld testing, electrical characterization, humidity exposure, radiation response, bend/mechanical tests, electrostatic discharge sensitivity, DIV, capacitance, and coupon level (both illuminated and dark) thermal cycling. With the exception of energetic charged particle irradiation and temperature-dependent LIV, all of the qualification tests are performed at Emcore. The coupon level thermal cycling testing known as ?combined effects? testing is designed to simulate the conditions the coupon will experience in geosynchronous Earth orbit (GEO). Emcore is in the process of establishing a combined effects test system to qualify the ZTJ as well as all future space solar cells to the S-111 standard. An overview of the design of the combined effects facility is presented, as well as test results. Initial data acquired from the combined effects chamber show 5.7% light uniformity over the illuminated panel area, and that the chamber meets the GEO temperature cycling requirements of -180?C to +80?C. The ZTJ cell exhibits a beginning of life (BOL) maximum power point efficiency of 29.5% (135.5 mW/cm2) under simulated AM0 illumination at 28?C. The ZTJ cell design incorporates features that have resulted in improved efficiency by 1% absolute over the previous generation BTJ cell while maintaining equivalent radiation hardness (84% remaining power) to 1 MeV electrons. Tests for temperature-dependent LIV, DIV, humidity, capacitance, ESD, and bend have been performed to date. Temperature coefficients for the ZTJ cell are: Voc = -6mV/?C, Jsc = 1.14E-2 mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /?C, FF = -4.33E-2/?C, Eff = -5.73E-2/?C, and max power = -0.312 mW/?C. The ZTJ cell is quite resistant to RB breakdown and human body model (HBM) ESD events, exhibiting an average RB breakdown voltage of -33.5V, and no change in DIV behavior following +/- 16 kV ESD pulses. Frequency-dependent capacitance measurements exhibit good agreement with theoretical models. In addition, negligible degradation is observed after 60 days of 45?C/95% humidity exposure, with a power remaining factor of 99.5%. Bend tests show that no fracture occurs until a bending diameter of 6".
Engineering NIR dyes for fluorescent lifetime contrast (2009)

The excited state of an organic molecule is a crossroads which can lead to many directions, such as non-radiative emission as heat, fluorescence, intersystem crossing and phosphorescence. Due to the unpredictable nature of the excited molecular structure, manipulation of this represents significant challenges for physicists and chemists. However, the successful management of the excited state provides a number of benefits with innumerable applications to fields like photonics and medicine. One such property of the excited state with powerful ramifications in medical diagnostics is fluorescence lifetime.
The effect of dopamine on the response to pattern stimulation--study of the chick ERG. (1994)

The effect of dopamine (DA) on the chick ERG was studied to evaluate its action on the on and off pathways and on the contrast mechanism with regard to background intensity. After intravitreal injection of DA, the b-wave, one component of the on response, was reduced with stimulus intensities lower than background intensity and enhanced with stimulus intensities that were higher. While the d-wave, one of the off responses, was enhanced with stimulus intensities higher than background intensity but not reduced with stimulus intensities that were lower. The pattern ERG amplitude was decreased at higher spatial frequencies. These results suggest that DA has different effects on the on and the off pathways as a function of the adaptive state and could affect the contrast mechanism.
Characterization of molecular association in acetone vapor. Thermal conductivity measurements and molecular orbital calculations (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of molecular association in acetone vapor. Thermal conductivity measurements and molecular orbital calculationsD. J. Frurip, L. A. Curtiss, and M. BlanderCite this: J. Phys. Chem. 1978, 82, 24, 2555–2561Publication Date (Print):November 1, 1978Publication History Published online1 May 2002Published inissue 1 November 1978https://pubs.acs.org/doi/10.1021/j100513a004https://doi.org/10.1021/j100513a004research-articleACS PublicationsRequest reuse permissionsArticle Views249Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts