gebhart/patrepeval huggingface dataset:
Chemical and Biological Folding Contribute to Temperature-Sensitive ΔF508 CFTR Trafficking (2020)

Proteostasis (Balch et al. (2008) Science 319: 916) refers to the biology that maintains the proteome in health and disease. Proteostasis is challenged by the most common mutation in cystic fibrosis, ΔF508, a chloride channel (the cystic fibrosis transmembrane conductance regulator (CFTR)) that exhibits a temperature-sensitive phenotype for coupling to the coatomer complex II (COPII) transport machine for exit from the endoplasmic reticulum (ER). Whether rescue of export of ΔF508-CFTR at reduced temperature simply reflects energetic stabilization of the chemical fold defined by its primary sequence, or requires a unique proteostasis environment is unknown. We now show that reduced temperature (30°C) export of ΔF508 does not occur in some cell types despite efficient export of wild-type CFTR. We find ΔF508 export requires a local biological folding environment that is sensitive to heat/stress inducible factors found in some cell types suggesting that the energetic stabilization by reduced temperature is necessary, but not sufficient for export of ΔF508. Thus, the cell may require a proteostasis environment that is in part distinct from the wild-type pathway to restore ΔF508 coupling to COPII. These results are discussed in the context of the energetics of the protein fold and the potential application of small molecules to achieve a proteostasis environment favoring export of a functional form of ΔF508.
Zero-shot Entity Linking with Less Data (2022)

G P Shrivatsa Bhargav, Dinesh Khandelwal, Saswati Dana, Dinesh Garg, Pavan Kapanipathi, Salim Roukos, Alexander Gray, L Venkata Subramaniam. Findings of the Association for Computational Linguistics: NAACL 2022. 2022.
On the Accuracy of the Cox–Strack Equation and Method for Contact Resistivity Determination (2020)

The Cox–Strack method is commonly applied to assess the contact resistivity between a metal and a semiconductor since the 1960s, while the underlying assumptions have not yet been rigorously assessed. In this article, a combination of finite-element modeling and mathematical analysis is used to investigate the accuracy of the conventional Cox–Strack equation for generic metal–semiconductor junctions. A systematic error in the spreading resistance equation is quantified, and alternative, more accurate equations are presented. Furthermore, it is shown that commonly used experimental configurations can lead to highly overestimated contact resistivities. Guidelines are formulated for accurate extraction of the contact resistivity from the Cox–Strack measurements.
Biological Variation of the Cardiac Index in Patients with Stable Chronic Heart Failure: Inert Gas Rebreathing Compared with Impedance Cardiography (2015)

Non-invasive measurements of CI are stable over time. Measurement modalities for CI, however, are not interchangeable. Biological variation is less pronounced when obtained by ICG. The influence of low-level exercise on stability of CI depends on the measurement modality.
Supplemental Figure 2 from MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor (2023)

&lt;p&gt;Supplemental Figure 2: The susceptibility of breast cancer cell lines to MCL-1 siRNA according to genotype and expression of BCL-2 family members.&lt;/p&gt;
Structural Nanocrystalline Materials: Fundamentals and Applications (2007)

Nanocrystalline materials exhibit exceptional mechanical properties, representing an exciting new class of structural materials for technological applications. The advancement of this important field depends on the development of new fabrication methods, and an appreciation of the underlying nano-scale and interface effects. This authored book addresses these essential issues, presenting for the first time a fundamental, coherent and current account at the theoretical and practical level of nanocrystalline and nanocomposite bulk materials and coatings. The subject is approached systematically, covering processing methods, key structural and mechanical properties, and a wealth of applications. This is a valuable resource for graduate students studying nanomaterials science and nanotechnologies, as well as researchers and practitioners in materials science and engineering
Elasticity management for capacity planning in software as a service cloud computing (2020)

Applications of cloud computing are increasing as companies shift from on-premise IT environments to public, private, or hybrid clouds. Consequently, cloud providers use capacity planning to maintain the capacity of computing resources (instances) required to meet the dynamic nature of the demand (queries). However, there is a trade-off between deploying too many costly instances, and deploying too few instances and paying penalties for not being able to process queries on-time. An instance has multiple resource dimensions and executing a query consumes multiple dimensions of an instance’s capacity. This detailed multi-dimensional management of cloud computing resource capacity is known as elasticity management and is an important issue faced by all cloud providers. Determining the optimal number of instances needed in a given planning horizon is challenging, due to the combinatorial nature of the optimization problem involved. We develop an optimization model and related algorithms to capture the trade-off between the resource cost versus the delayed execution penalty in software as a service applications from the cloud provider’s perspective. We develop an exact approach to solve small to medium sized applications and heuristics to solve large applications. We then evaluate their performance via extensive computational analyses with real-world data and current cloud provider approaches. We also develop a stochastic framework and methodology to deal with demand uncertainty, and using two different randomly generated data sets (representing problem instances in practice), we demonstrate that robust solutions can be obtained.
Design of Location Service for a Hybrid Network of Mobile Actors and Static Sensors (2006)

Location services are essential to many applications running on a hybrid of wirelessly-networked mobile actors and static sensors, such as surveillance systems and the pursuer and evader game (PEG). To our best knowledge, there has been no previous location service protocol for wireless sensor networks. A number of location service protocols have been proposed for mobile ad hoc networks, but they are not applicable to sensor networks due to the usually large per-hop latency between sensors. This paper presents a distributed location service protocol (DLSP) for wireless sensor networks. Using a rigorous analysis of DLSP, we derive the condition for achieving a high packet-delivery ratio, and show how to configure the protocol parameters to ensure the scalability of DLSP. We find that DLSP is scalable if the mobile's speed is below a certain fraction of the packet-transmission speed, which depends on a movement threshold. For example, if the movement threshold for the location servers at the lowest level equals the radio range, the speed limit is one-tenth of the packet-transmission speed. The mobile's theoretical speed limit is one-fifth of the packet-transmission speed, beyond which DLSP cannot scale regardless of the movement threshold. Because of the high location-update overhead of DLSP, we propose an optimization, DLSP-SN, which can reduce the overhead by over 70%, while achieving high packet-delivery ratios. However, due to the griding effect, the packet's path length of DLSP-SN may be longer than that of DLSP, incurring higher data-delivery cost
Elaboration d’électrodes de pile à combustible par plasma (2006)

Cette these en cotutelle resulte de la collaboration entre le laboratoire francais GREMI (Orleans) et le groupe australien SP3 (Universite National Australienne) sur l’optimisation des piles a combustible par procede plasma. Mon projet d’etude concerne le developpement d’une electrode de pile a combustible constituee d’une nanostructure carbonee impregnee d’agregats de catalyseur platine, l’enjeu etant de reduire la quantite de platine tout en conservant de bonnes performances electrochimiques. Durant la premiere partie passee en France, des electrodes traditionnelles non catalysees ont ete impregnees d’agregats de platine sur quelques centaines de nanometres par pulverisation plasma. Cette methode a permis de reduire considerablement la charge de platine par rapport a une electrode traditionnelle catalysee chimiquement tout en reduisant legerement ses performances. La seconde moitie de ma these en Australie concerna la croissance d’un support catalytique carbone de grande surface specifique optimise pour l’application pile a combustible. Des nanofibres de carbone (CNF) ont donc ete deposees sur du papier de carbone recouvert d’une fine couche de nickel en utilisant un procede CVD (Chemical Vapor Deposition) dans un reacteur plasma Helicon que j’ai concu et developpe. La morphologie des CNF a ete caracterisee et optimisee en fonction des parametres plasmas. Ce tapis de CNF a ete impregne d’agregats de platine par pulverisation plasma Helicon. Dans cette nouvelle electrode entierement realisee par plasma, le catalyseur est cette fois reparti sur quelques micrometres ce qui permettra d’augmenter les performances electriques de la pile.
Deuterium-incorporated gate oxide of MOS devices fabricated by using deuterium ion implantation (2012)

In the aspect of metal-oxide-semiconductor (MOS) device reliability, deuterium-incorporated gate oxide could be utilized to suppress the wear-out that is combined with oxide trap generation. An alternative deuterium process for the passivation of oxide traps or defects in the gate oxide of MOS devices has been suggested in this study. The deuterium ion is delivered to the location where the gate oxide resides by using an implantation process and subsequent N2 annealing process at the back-end of metallization process. A conventional MOS field-effect transistor (MOSFET) with a 3-nm-thick gate oxide and poly-to-ploy capacitor sandwiched with 20-nm-thick SiO2 were fabricated in order to demonstrate the deuterium effect in our process. An optimum condition of ion implantation was necessary to account for the topography of the overlaying layers in the device structure and to minimize the physical damage due to the energy of the implanted ion. Device parameter variations, the gate leakage current, and the dielectric breakdown phenomenon were investigated in the deuterium-ion-implanted devices. We found the isotope effect between hydrogen- and deuterium-implanted devices and an improved electrical reliability in the deuterated gate oxide. This implies that deuterium bonds are generated effectively at the Si/SiO2 interface and in the SiO2 bulk.
Efficient Generation of Mucosal and Systemic Antigen-Specific CD8+T-Cell Responses following Pulmonary DNA Immunization (2010)

Although mucosal CD8(+) T-cell responses are important in combating mucosal infections, the generation of such immune responses by vaccination remains problematic. In the present study, we evaluated the ability of plasmid DNA to induce local and systemic antigen-specific CD8(+) T-cell responses after pulmonary administration. We show that the pulmonary delivery of plasmid DNA formulated with polyethyleneimine (PEI-DNA) induced robust systemic CD8(+) T-cell responses that were comparable in magnitude to those generated by intramuscular (i.m.) immunization. Most importantly, we observed that the pulmonary delivery of PEI-DNA elicited a 10-fold-greater antigen-specific CD8(+) T-cell response in lungs and draining lymph nodes of mice than that of i.m. immunization. The functional evaluation of these pulmonary CD8(+) T cells revealed that they produced type I cytokines, and pulmonary immunization with PEI-DNA induced lung-associated antigen-specific CD4(+) T cells that produced higher levels of interleukin-2 than those induced by i.m. immunization. Pulmonary PEI-DNA immunization also induced CD8(+) T-cell responses in the gut and vaginal mucosa. Finally, pulmonary, but not i.m., plasmid DNA vaccination protected mice from a lethal recombinant vaccinia virus challenge. These findings suggest that pulmonary PEI-DNA immunization might be a useful approach for immunizing against pulmonary pathogens and might also protect against infections initiated at other mucosal sites.
Temperature dependence of terahertz emission from InMnAs (2007)

We have studied the terahertz radiation emitted by the dilute magnetic semiconductor InMnAs under femtosecond laser illumination, as a function of temperature. We observe a reversal of the polarity of the emitted terahertz field as the temperature is decreased, in both p-type and n-type materials. This effect is not observed in p-InAs. A competition between two oppositely directed currents, the photo-Dember current and the surface-field-induced current, can explain the observed polarity reversal. In contrast to nonmagnetic materials, these two currents are of comparable magnitude because the Mn impurity substantially reduces the carrier mobility in dilute magnetic semiconductors.
About Auteuring Requirements - Lessons from Filmmaking (2018)

Success or failure of software development projects is strongly correlated with the quality of requirements. The question: How to make RE effective continues to intrigue RE practitioners and researchers alike. The pursuit of answer to this question has encouraged researchers to explore other disciplines with the goal of finding similar challenges and possible solution patterns. We conducted an analysis of film industry processes and film theories with an aim to draw lessons for RE. In this paper, we present our observations and recommendations for RE from the Auteur theory of film criticism and script writing practices of filmmaking.
Instantaneous freuqnecy measurement for broadband radio signals using optical single sideband modulation (2017)

By using optical single sideband modulation, we demonstrated instantaneous frequency measurement, which would be useful to monitor wideband radio signals with agile frequency change.
Innovative wool geotextiles designed for erosion protection (2017)

Innovative geotextiles built from meandrically arranged thick ropes were produced. For the production of the geotextiles, the strips of woollen nonwoven were used. The segments of the geotextiles were installed on the bank of a drainage ditch. The behaviour of the geotextiles during 1 year was observed. It was demonstrated that the geotextiles installed in the ditch provide immediate protection of the bank. In the soil-covered wool, the process of slow biodegradation was initiated. Because of a low biodegradation rate at the end of the growing season, when the protective vegetation was not well developed, the geotextiles maintained their protective potential. In the following months, the biodegradation led to further destruction of wool fibres. During the biodegradation, the organic compounds rich in nitrogen were released into the soil. In spring, at the beginning of new growing season, the compounds acted as effective fertilizers, promoting the growth of protective vegetation. The vegetation growing on the bank provided an effective protection and took over the protective function of the geotextiles.
Contrasting weight changes with LY2605541, a novel long-acting insulin, and insulin glargine despite similar improved glycemic control in T1D and T2D (2013)

Objectives: The basal insulin analog LY2605541 (LY) is a PEGylated insulin lispro with a large hydrodynamic size which delays insulin absorption and reduces clearance, resulting in prolonged duration of action. Improved glycemic control with insulin generally results in weight gain. The present studies investigated how once-daily LY that showed glycemic control comparable with or superior to insulin glargine (GL), relates to weight gain in patients with type 1 or type 2 diabetes.
Diffusely Abnormal White Matter in Progressive Multiple Sclerosis: In Vivo Quantitative MR Imaging Characterization and Comparison between Disease Types (2009)

In vivo T1, MTR, ADC, and FA reflect the variable severity of pathologic changes in DAWM in MS. Moreover, these quantitative MR imaging measures suggest that DAWM may differ between PPMS and SPMS.
Appendix A: Glossary of Terms (2013)

Air Ionizer: An electronic or nuclear device that generate ions from air to be used for dissipation of static charge typically used in manufacturing and assembly environments.Antistatic: Material or coating that prevents static buildup on worksurfaces, or materials.An antistatic agent is a compound used for treatment of materials or their surfaces in order to reduce or eliminate buildup of static electricity generally caused by the triboelectric effect. Atomic Force Microscope (AFM):A microscope used for failure analysis and observation of semiconductor chips that can observe images at the atomic level.Audit: Business process review to verify conformance and compliance to ESD procedures and standards.Cable Discharge Event (CDE): An electrostatic discharge event from a cable source.Cassette Model: A test method whose source is a capacitor network with a 10 pF capacitor.This is also known as the Small Charge Model (SCM), and the "Nintendo model". Charged Board Event (CBE):A test method for evaluation of the charging of a packaged semiconductor chip mounted on a board, followed by a grounding process.The semiconductor chip is mounted on a board during this test procedure.The board is placed on an insulator during this test.Charged Device Model (CDM): A test method for evaluation of the charging of a packaged semiconductor chip, followed by a grounding a pin.The semiconductor chip is not socketed but placed on an insulator during the test.Chip-on-Board (COB): A configuration which is a chip directly attached to a printed circuit board or substrate by soldering or conductive adhesive.Circuit Breaker: An electrical over-current (EOC) protection circuit element.
The actin filament cross‐linker L‐plastin confers resistance to TNF‐α in MCF‐7 breast cancer cells in a phosphorylation‐dependent manner (2009)

Abstract We used a tumour necrosis factor (TNF)‐α resistant breast adenocarcinoma MCF‐7 cell line to investigate the involvement of the actin cytoskeleton in the mechanism of cell resistance to this cytokine. We found that TNF resistance correlates with the loss of cell epithelial properties and the gain of a mesenchymal phenotype, reminiscent of an epithelial‐to‐mesenchymal transition (EMT). Morphological changes were associated with a profound reorganization of the actin cytoskeleton and with a change in the repertoire of expressed actin cytoskeleton genes and EMT markers, as revealed by DNA microarray‐based expression profiling. L‐plastin, an F‐actin cross‐linking and stabilizing protein, was identified as one of the most significantly up‐regulated genes in TNF‐resistant cells. Knockdown of L‐plastin in these cells revealed its crucial role in conferring TNF resistance. Importantly, overexpression of wild‐type L‐plastin in TNF‐sensitive MCF‐7 cells was sufficient to protect them against TNF‐mediated cell death. Furthermore, we found that this effect is dependent on serine‐5 phosphorylation of L‐plastin and that non‐conventional protein kinase C isoforms and the ceramide pathway may regulate its phosphorylation state. The protective role of L‐plastin was not restricted to TNF‐α resistant MCF‐7 cells because a correlation between the expression of L‐plastin and the resistance to TNF‐α was observed in other breast cancer cell lines. Together, our study discloses a novel unexpected role of the actin bundling protein L‐plastin as a cell protective protein against TNF‐cytotoxicity.
Inclusion complex formation by transition-metal complexes containing a void in proximity to a site that can be made catalytically active (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInclusion complex formation by transition-metal complexes containing a void in proximity to a site that can be made catalytically activeKenneth J. Takeuchi and Daryle H. BuschCite this: J. Am. Chem. Soc. 1983, 105, 23, 6812–6816Publication Date (Print):November 1, 1983Publication History Published online1 May 2002Published inissue 1 November 1983https://pubs.acs.org/doi/10.1021/ja00361a011https://doi.org/10.1021/ja00361a011research-articleACS PublicationsRequest reuse permissionsArticle Views51Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Information from SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer (2023)

&lt;p&gt;Figures S1-S2-S3 + Suppl. Fig. legends + Suppl. Methods&lt;/p&gt;
10 GHz short pulse generation using a 1.55 μm hybrid distributed Bragg reflector (HDBR) laser source (2002)

We report, for the first time, to our knowledge, the realisation of a HDBR (hybrid distributed Bragg reflector) laser for picosecond optical pulse generation at about 10 GHz repetition rate. 12.7 ps pulses, with 400 MHz locking bandwidth have been obtained.
Acoustic feedback control in hearing aids with frequency warping (2023)

Acoustic Feedback Control continues to be a challenging problem due to the emerging form factors in advanced hearing aids and hearables, especially for severe and profound losses. In order to mitigate the effects of feedback in hearing aids, we present a novel use of frequency warping called “Freping,” for manipulating signals in the frequency domain. Freping is a non-linear transformation which breaks the similarity between the input and acoustic feedback signals of a hearing aid to prevent feedback. In this work, we implemented Freping in realtime for feedback management, as well as novel techniques to preserve the naturalness of sound. Our prior work has shown that Freping improves Added Stable Gain (ASG) in the presence of feedback while maintaining the same Hearing Aid Speech Quality Index (HASQI). We present new results for feedback management with Freping by performing “on-ear” measurements on an acoustic KEMAR manikin using standard hearing aid verification systems. We conducted feedback tests to measure the ASG with various configurations of Freping for various hearing loss levels using the NAL-NL2 prescriptions on a realtime open-source speech processing system for hearing aids. We also compare Freping feedback performance with that of commercial hearing aids.
Embedded Machine Learning on Accelerometer Data for Exercise Classification (2023)

This paper describes the use of embedded machine learning (ML) on raw accelerometer data to classify three lower-limb exercises. The developed model, which uses supervised ML can accurately classify the exercises. The model performed with an accuracy of 99.41 % on the test data and F1 score of 0.99. The trained model is deployed on the microcontroller board, Arduino Nano 33 BLE Sense (ARM Cortex M4F processer). The system has been developed using open-source platforms. The developed wearable device, PhysioSens has the potential to enhance limb exercise monitoring in home-based physical therapy.