gebhart/patrepeval huggingface dataset:
Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B‐cell lymphoma (2016)

Primary mediastinal B-cell lymphoma (PMBL) is an entity of B-cell lymphoma distinct from the other molecular subtypes of diffuse large B-cell lymphoma (DLBCL). We investigated the prevalence, specificity, and clinical relevance of mutations of XPO1, which encodes a member of the karyopherin-β nuclear transporters, in a large cohort of PMBL. PMBL cases defined histologically or by gene expression profiling (GEP) were sequenced and the XPO1 mutational status was correlated to genetic and clinical characteristics. The XPO1 mutational status was also assessed in DLBCL, Hodgkin lymphoma (HL) and mediastinal gray-zone lymphoma (MGZL).The biological impact of the mutation on Selective Inhibitor of Nuclear Export (SINE) compounds (KPT-185/330) sensitivity was investigated in vitro. XPO1 mutations were present in 28/117 (24%) PMBL cases and in 5/19 (26%) HL cases but absent/rare in MGZL (0/20) or DLBCL (3/197). A higher prevalence (50%) of the recurrent codon 571 variant (p.E571K) was observed in GEP-defined PMBL and was associated with shorter PFS. Age, International Prognostic Index and bulky mass were similar in XPO1 mutant and wild-type cases. KPT-185 induced a dose-dependent decrease in cell proliferation and increased cell-death in PMBL cell lines harboring wild type or XPO1 E571K mutant alleles. Experiments in transfected U2OS cells further confirmed that the XPO1 E571K mutation does not have a drastic impact on KPT-330 binding. To conclude the XPO1 E571K mutation represents a genetic hallmark of the PMBL subtype and serves as a new relevant PMBL biomarker. SINE compounds appear active for both mutated and wild-type protein. Am. J. Hematol. 91:923-930, 2016. © 2016 Wiley Periodicals, Inc.
Jean-Jacques Bourdin au service de la démocratie ? Sociologie des rôles et conflictualité lors des interviews matinales (2021)

International audience
Biomass Pyrolysis and Gasification of Varying Particle Sizes in a Fluidized-Bed Reactor (2011)

A new 4 in. (102 mm) diameter fluidized-bed reactor has been built and used to study the effect of biomass particle size on the yield of light gas and tar compounds during gasification. Batch experiments were conducted with white oak milled into four sphere sizes with diameters of 6, 13, 18, and 25 mm, at reactor bed temperatures of 500, 600, 700, 800, and 900 °C. As expected, the yields of light gas increase with temperature but then reach a plateau above 800 °C. As the particle size increases, a decrease in the formation of light gases, accompanied by an increase in the formation of char, is observed. For larger particle sizes, the commonly used power law dependence of particle devolatilization time with sphere diameter holds true and the transition from heat- and mass-transport control to kinetic control as particle diameter decreases is illustrated. Measurements of the organic compounds present in the syngas are performed using a molecular beam mass spectrometer (MBMS). These measurements indicate that, as the size of the spheres increases, the formation of tars and polycyclic aromatic hydrocarbons (PAHs) increases. These observations further emphasize the important role of heat- and mass-transport restrictions for larger particles in the evolution of products during gasification and its potential implications on gasification process economics.
PDP-11 Computer Monitoring System. (1978)

Abstract : This report describes a hardware system for controlling and accounting for use of up to 15 PDP-11's with up to 700 users. The system functions much like a software accounting system on a large time-sharing system and is designed for compatibility with DEC system-10 accounting packages. The hardware includes an SBC-80/10 microcomputer interface located in each PDP-11. The interface requires one system unit in the PDP-11 box. The interface becomes 'bus master' when the PDP-11 is turned on. It remains 'bus master' until the PDP-11 user has correctly 'logged on' to the system through the console terminal. The accounting data and user identification are stored on a PDP-11/04 system which communicates with each SBC-80/10 microcomputer via a serial RS232 communications link. The user identification is generated in a DEC system-10 and transferred to the PDP-11/04 over a serial asynchronous communication link. Account data is periodically transferred to the DEC system-10 via the same communications path. (Author)
User defined files (1981)

In the past, there has been conflict between the application programmer's desire for specialized file types and the system programmer's desire to keep the operating system compact. A solution is proposed that allows a simple file or group of simple files to be encapsulated by a user program. The resulting entity (called a user-defined file) allows arbitrarily complex special-purpose file types to be emulated without continuous modifications to the operating system.
Fabrication and analysis of a directional coupler written in glass by nanojoule femtosecond laser pulses (2001)

A directional coupler written in a glass sample by the focused 400-nm output from a 25-fs oscillator is reported. The coupler is single mode; the splitting ratio is 1.9 dB at 633 nm. A refractive-index profile of the waveguide with a magnitude of Dn = 4.5 x 10(-3) was retrieved from a near-field mode pattern.
Definition and Analysis of an Innovative Ancillary Service for Microgrid Stability Improvement (2018)

In micro-grids, due to the heavy penetration of distributed energy resources (DERs), especially renewable energy sources (RESs), the characteristic inertia of the system has been decreasing with respect to the total power capacity. In a weak grid, a high step variation of the load leads to a hard transient of frequency. This could imply stability issues for the grid and specific problems for sensitive loads. In order to face this problem, in the technical literature, several algorithms introducing virtual inertia in the system have been proposed. Since, these algorithms are based on the assumption that an equivalent inertia has to be simulated, they need to exchange active power with the network. When this function is implemented in a PV system, a power reserve or an additional storage unit has to be used. In this paper, a technique to increase the transient stability of the generation system, based only on the exchange of reactive power, will be proposed. Its feasibility is demonstrated by means of numerical simulations.
Application of Atelocollagen-mediated siRNA Delivery for RNAi Therapies (2007)

RNAi has rapidly become a powerful tool for drug target discovery and validation in an in vitro culture system and, consequently, interest is rapidly growing for extension of its application to in vivo systems, such as animal disease models and human therapeutics. Novel treatments and drug discovery in pre-clinical studies based on RNAi are currently targeting a wide range of diseases, including viral infections and cancers by the local administration of synthetic small interfering RNA (siRNA) that target local lesions. Recently, specific methods for the systemic administration of siRNAs have been reported to treat non-human primates or a cancer metastasis model. In vivo siRNA-delivery technology is a key hurdle to the successful therapeutic application of RNAi. This article reviews the non-viral delivery system of atelocollagen for siRNA, which could be useful for functional screening of the genes in vitro and in vivo, and will provide a foundation for further development of RNAi therapeutics.
Constrained least squares detector for OFDM/SDMA-based wireless networks (2002)

The two major obstacles towards high-capacity indoor wireless networks are distortion due to the indoor channel and the limited bandwidth. A combined OFDM/SDMA approach efficiently tackles both obstacles and paves the way for low cost, high-capacity wireless indoor networks (see Vandenameele, P. et al., VTC Spring, p.1712-16, 1999; IEEE J. Selected Areas in Commun., vol.18, no.11, p.2312-21, 2000). Channel distortion due to multipath propagation is efficiently mitigated by orthogonal frequency division multiplexing (OFDM) while the bandwidth efficiency is increased by the use of spatial diversity multiple access (SDMA). To keep the WLAN cost low, simple SDMA processors with good performance are necessary. Hence, we propose a new, low-complexity multiuser SDMA detector, which is designed for constant modulus signals. This linear constrained least squares (CLS) receiver, which explicitly exploits the constant modulus nature of subcarrier modulation to achieve better separation, is compared in terms of performance and complexity with the zero forcing (ZF) and the minimum mean square error (MMSE) receivers. Simulations show that the CLS detector significantly outperforms the ZF detector and comes close to the performance of the MMSE detector for QPSK. For higher order MPSK, the CLS detector outperforms the MMSE detector substantially.
A multicentre, randomised, parallel‐group, double‐blind, vehicle‐controlled and open‐label, active‐controlled study (versus amorolfine 5%), to evaluate the efficacy and safety of terbinafine 10% nail lacquer in the treatment of onychomycosis (2021)

Terbinafine 10% nail lacquer was an effective treatment for mild-to-moderate onychomycosis improving both clinical and mycological criteria compared with vehicle. Furthermore, there may be some benefits compared to the currently available topical agent, amorolfine 5%. Treatment was well-tolerated and safe.
Improved combined cycle power plant operation design using optimization method (1992)

Abstract Combined cycle power plant takes advantage of the efficiency, fast startup, and small environmental impact. The operation design of this plant is required to make best use of this plant advantage. A large‐scale nonlinear mathematical model of this plant was developed to check the plant condition. This simulation model was combined with the optimization using Rosenbrock method. The operation design is optimized in two steps; [Step 1]: Some points of plant condition can be checked roughly; [Step 2]: This plant operation is optimized to design using Rosenbrock method. This optimization is applied to design the combined cycle power plant operation. It is confirmed that this method is effective for the design of plant operation. From this study, plant operation can be designed with this optimization to make best use of this plant advantage. Then operation design point is decided using the optimization method on some evaluation instead of heuristic method.
Supplementary Tables from Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho (2023)

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Supplementary Table 1 from Bcl9/Bcl9l Are Critical for Wnt-Mediated Regulation of Stem Cell Traits in Colon Epithelium and Adenocarcinomas (2023)

Supplementary Table 1 from Bcl9/Bcl9l Are Critical for Wnt-Mediated Regulation of Stem Cell Traits in Colon Epithelium and Adenocarcinomas
AC Impedance Studies on Metal Hydride Electrodes (1995)

The metal hydride electrode is the negative electrode in one of the most advanced secondary batteries (i.e., nickel/metal hydride). The objective of this study is to obtain insight on the mechanism of the hydriding/dehydriding reaction in the battery by using the electrochemical impedance spectroscopy (EIS) technique. An equivalent circuit for the electrode reaction is proposed. The rate capability of charge and discharge of the electrode is determined by the kinetics of the charge‐transfer reaction at the alloy surface, which is mainly represented by the EIS responses in the low frequency region. Transient and pseudo‐steady‐state analyses (cyclic voltammetry and potential vs. current density behavior) qualitatively and quantitatively support the EIS results. EIS studies on electrodes with (i) three types of binding additives, (ii) varying amounts of active material, and (iii) two types of alloys as active materials demonstrate the usefulness of this technique for developing electrodes with the optimum composition and structure.
Photonic switching by tunnelling-assisted absorption modulation in a GaAs sawtooth structure (1988)

We report on an electrically controlled optical modulator using a novel GaAs sawtooth structure. This structure consists of alternating n-type and p-type delta-doped GaAs. Modulation of tunnelling-assisted absorption is achieved by changing the internal electric field which in turn is controlled by external bias. Modulation of light intensity is demonstrated over a broad spectral range of Δλ &gt; 100 nm. A contrast ratio of 1 : 1.7 of the opaque and transparent states is obtained. Low-voltage operation (ΔV &lt; 5V) and potential high-speed capability make the new device an attractive candidate for future photonic switching systems.
Stand-alone wind system with Vanadium Redox Battery energy storage (2008)

Energy storage devices are required for power balance and power quality in stand alone wind energy systems. A Vanadium Redox Flow Battery (VRB) system has many features which make its integration with a stand alone wind energy system attractive. This paper proposes the integration of a VRB system with a typical stand-alone wind energy system during wind speed variation as well as transient performance under variable load. The investigated system consists of a variable speed wind turbine with permanent magnet synchronous generator (PMSG), diode rectifier bridge, buck-boost converter, bidirectional charge controller, transformer, inverter, ac loads and VRB (to store a surplus of wind energy and to supply power during a wind power shortage). The main purpose is to supply domestic appliances through a single phase 230 V, 50 Hz inverter. Simulations are accomplished in order to validate the stability of the supply.
Abstract 219: Cardiac Angiogenic Imbalance Leads to Peripartum Cardiomyopathy (2012)

Peri-partum cardiomyopathy (PPCM) is a frequently fatal disease that affects women near delivery, and occurs more frequently in women with pre-eclampsia and/or multiple gestation. The etiology of PPCM, or why it associates with pre-eclampsia, remains unknown. We show here that PPCM is associated with a systemic angiogenic imbalance, accentuated by pre-eclampsia. Mice that lack cardiac PGC-1α, a powerful regulator of angiogenesis, develop profound PPCM. Importantly, the PPCM is entirely rescued by pro-angiogenic therapies. In humans, the placenta in late gestation secretes VEGF inhibitors like soluble Flt1 (sFlt1), and this is accentuated by multiple gestation and pre-eclampsia. This anti-angiogenic environment is accompanied by sub-clinical cardiac dysfunction, the extent of which correlates with circulating levels of sFlt1. Exogenous sFlt1 alone caused diastolic dysfunction in wildtype mice, and profound systolic dysfunction in mice lacking cardiac PGC-1α. Finally, plasma samples from women with PPCM contained abnormally high levels of sFlt1. These data strongly suggest that PPCM is in large part a vascular disease, caused by excess anti-angiogenic signaling in the peri-partum period. The data also explain how late pregnancy poses a threat to cardiac homeostasis, and why pre-eclampsia and multiple gestation are important risk factors for the development of PPCM.
Characterization of a Novel Staphylococcal Enterotoxin-like Superantigen, a Member of the Group V Subfamily of Pyrogenic Toxins (2002)

Staphylococcus aureus is an important human pathogen, causing a variety of diseases. Major virulence factors of this organism include staphylococcal enterotoxins (SEs) that cause food poisoning and toxic shock syndrome. Our study identified a novel enterotoxin-like protein that is a member of the new subfamily (group V) of pyrogenic toxin superantigens (PTSAgs) and examined its biochemical and immunobiological properties. The gene encoding the SE-like protein is directly 5' of another recently identified PTSAg, SEK. The SE-like protein had a molecular weight of 26000 and an experimentally determined isoelectric point between 7.5 and 8.0. We demonstrated that the PTSAg had many of the biological activities associated with SEs, including superantigenicity, pyrogenicity, and ability to enhance endotoxin shock, but lacked both lethality in rabbits when administered in subcutaneous miniosmotic pumps and emetic activity in monkeys. Recombinant protein stimulated human CD4 and CD8 T cells in a T cell receptor variable region, beta chain (TCRVbeta) specific manner. T cells bearing TCRVbeta 2, 5.1, and 21.3 were significantly stimulated.
Effects of Estrogen and Prolactin on Bovine BRCA1 Gene Expression (2001)

Primary cultures of bovine mammary secretory epithelial cells and spontaneously transformed mammary secretory epithelial cells were treated with estradiol 17-s or prolactin separately and in combination with both hormones. Both estradiol and prolactin induced BRCA1 expression in the cells. Hormone induced expression of BRCA1 was highest in transformed cells. Moreover, the induction of BRCA1 gene expression was highest when both estrogen and prolactin were in the culture medium. Gel shift assays showed that STAT5a antibody bound to a 20-bp double stranded oligonucleotide, containing a potential STAT5 response element (5'-acagtttctaaggaacactg-3', 3'-tgtcaaagattccttgtgac-5'). This is the first report showing that bovine mammary cells, in culture, are responsive to estrogen and prolactin in inducing expression of bovine BRCA1 and that BRCA1 may contain a STAT5 response element directing expression of the bovine BRCA1 gene. Further work is needed to examine the presence of estrogen response element(s) in estradiol induced BRCA1 expression. One must determine if PRL induced BRCA1 induction occurs after transfection of STAT5 -/- cells with STAT5a and STAT5a mutant constructs. This will give the strongest evidence of the direct involvement of a STAT5-BRCA1 signaling pathway.
Modulating entropic driving forces to promote high lithium mobility in solid organic electrolytes (2023)

As large-scale lithium-ion battery deployment accelerates, continued use of flammable organic electrolytes exacerbate issues associated with battery fires during operation and disposal. While ionic liquid-derived electrolytes promise safe, nonflammable alternatives to carbonate electrolytes, use of ionic liquids in batteries is hindered by poor lithium transport due to formation of long-lived lithium-anion complexes. We report the design and characterization of novel ionic liquid-inspired organic electrolytes that leverage unique self-assembly properties of molecular diamond templates, called “diamondoids.” Combining thermodynamic characterization, vibrational and magnetic spectroscopy, and single-crystal X-ray analysis, we determine that diamondoid-functionalized cations can facilitate formation of molecularly porous phases that resist restructuring upon dissolution of lithium salts. These electrolytes can suppress lithium-anion coordination, manifesting in substantially enhanced lithium-ion mobility in the organic ion matrix. Our results provide a new paradigm for enhancing lithium mobility in solid electrolytes by tuning entropic self-assembly to enhance organic cation-anion interactions, suppress lithium-anion coordination, and increase lithium mobility in solid electrolytes.
Increased Viral Loads and Exacerbated Innate Host Responses in Aged Macaques Infected with the 2009 Pandemic H1N1 Influenza A Virus (2012)

In contrast to seasonal influenza virus infections, which typically cause significant morbidity and mortality in the elderly, the 2009 H1N1 virus caused severe infection in young adults. This phenomenon was attributed to the presence of cross-protective antibodies acquired by older individuals during previous exposures to H1N1 viruses. However, this hypothesis could not be empirically tested. To address this question, we compared viral replication and the development of the immune response in naïve young adult and aged female rhesus macaques infected with A/California/04/2009 H1N1 (CA04) virus. We show higher viral loads in the bronchoalveolar lavage (BAL) fluid and nasal and ocular swabs in aged animals, suggesting increased viral replication in both the lower and upper respiratory tracts. T cell proliferation was higher in the BAL fluid but delayed and reduced in peripheral blood in aged animals. This delay in proliferation correlated with a reduced frequency of effector CD4 T cells in old animals. Aged animals also mobilized inflammatory cytokines to higher levels in the BAL fluid. Finally, we compared changes in gene expression using microarray analysis of BAL fluid samples. Our analyses revealed that the largest difference in host response between aged and young adult animals was detected at day 4 postinfection, with a significantly higher induction of genes associated with inflammation and the innate immune response in aged animals. Overall, our data suggest that, in the absence of preexisting antibodies, CA04 infection in aged macaques is associated with changes in innate and adaptive immune responses that were shown to correlate with increased disease severity in other respiratory disease models.
The business model and platform strategy of social TV: A case study (2014)

Social TV has been rapidly developing in recent years. However, it has not been discussed how to connect social interactions among users to business models. This study conducts a single case study of social TV, namely Afreeca TV. Not only watching but operating broadcasting channels are allowed in Afreeca TV. It differs in terms of providing strong monetary incentives for users to operate personal channels. It generates revenue from selling gift items, which are used for viewers to give presents to broadcasting jockeys. Based on this case, the current study suggests insightful propositions for the Internet media enterprises.
Implementation and field demonstration of PacketBLAST system for tactical communications (2006)

Multiple Input Multiple Output (MIMO) wireless communications vastly expand the capacity and connectivity of communications for forces operating in challenging environments such as urban or forested terrain. A MIMO architecture called BLAST (Bell Laboratories Layered Space-Time) has been formulated to realize these capacities. We have developed a packet version of BLAST, called PacketBLAST, specifically to support high mobility, ad-hoc, tactical communications on the move in challenging environments. PacketBLAST offers a number of benefits to tactical communications. We have implemented a first-ever, end-to-end mobile, ad-hoc network (MANET) of PacketBLAST nodes and have successfully tested it in a number of field demonstrations.