gebhart/patrepeval huggingface dataset:
Boronic Acid for the Traceless Delivery of Proteins into Cells (2015)

The use of exogenous proteins as intracellular probes and therapeutic agents is in its infancy. A major hurdle has been the delivery of native proteins to an intracellular site of action. Herein, we report on a compact delivery vehicle that employs the intrinsic affinity of boronic acids for the carbohydrates that coat the surface of mammalian cells. In the vehicle, benzoxaborole is linked to protein amino groups via a "trimethyl lock." Immolation of this linker is triggered by cellular esterases, releasing native protein. Efficacy is demonstrated by enhanced delivery of green fluorescent protein and a cytotoxic ribonuclease into mammalian cells. This versatile strategy provides new opportunities in chemical biology and pharmacology.
815 The Study on Hybrid Active Noise Contorl Usitrg a Resonator (2001)

Many of the noise in ducts, such as air intake noise of vehicles, contain single or multiple large periodic and broadband random noise. Generally, such air intake noise is reduced with multiple resonators that require large-sized area. On the other hand, there are many applications of ANC with Filtered-X LMS algorithm for ductlike structures. However, if the target noise contains very large periodic component, it is difficult to reduce the broadband random noise sufficiently by ANC. In this study, we suggest to apply a new system, namely "hybrid ANC system", in which a Helmholtz resonator is utilized. In the application to the duct noise containing single or multiple periodic components, hybrid ANC can reduce both of the periodic and broadband random noise more effectively than any conventional ANC system.
Highly Mesoporous Single-Crystalline Zeolite Beta Synthesized Using a Nonsurfactant Cationic Polymer as a Dual-Function Template (2014)

Mesoporous zeolites are useful solid catalysts for conversion of bulky molecules because they offer fast mass transfer along with size and shape selectivity. We report here the successful synthesis of mesoporous aluminosilicate zeolite Beta from a commercial cationic polymer that acts as a dual-function template to generate zeolitic micropores and mesopores simultaneously. This is the first demonstration of a single nonsurfactant polymer acting as such a template. Using high-resolution electron microscopy and tomography, we discovered that the resulting material (Beta-MS) has abundant and highly interconnected mesopores. More importantly, we demonstrated using a three-dimensional electron diffraction technique that each Beta-MS particle is a single crystal, whereas most previously reported mesoporous zeolites are comprised of nanosized zeolitic grains with random orientations. The use of nonsurfactant templates is essential to gaining single-crystalline mesoporous zeolites. The single-crystalline nature endows Beta-MS with better hydrothermal stability compared with surfactant-derived mesoporous zeolite Beta. Beta-MS also exhibited remarkably higher catalytic activity than did conventional zeolite Beta in acid-catalyzed reactions involving large molecules.
Hydrogel-Based Integrated Antenna-pH Sensor (2007)

In this paper, a miniaturized integrated antenna-sensor based on a pH-sensitive hydrogel is designed, fabricated and characterized. The proposed sensor geometry is based on a 5-mm-long slot antenna whose frequency is controlled by a back-metal coated on the pH-sensitive hydrogel that is patterned on a glass substrate. When the antenna is immersed in a solution whose pH changes from 5 to 12 it shows a variation of its resonant frequency by approximately 160 MHz around a center frequency of 21.7 GHz. Except for an abnormal behavior around the pH=l state caused by the back-metal-hydrogel bond, the pH-antenna frequency mapping exhibits a well-defined monotonic region from pH=5 to 12 thus covering many practical solutions.
Nanostructured and Self-Assembled Superhydrophilic Bipolar Plate Coatings for Fuel Cell Water Management (2009)

Layer-by-Layer (LbL) assembly of silica nanoparticles onto Proton Exchange Membrane Fuel Cell (PEMFC) bipolar plates is demonstrated for enhanced hydrophilicity (contact angle < 15o), enabling effective water management and stable low-power operation of a FC stack. Besides superhydrophilicity, the coating nanostructure and thickness are tailored to meet other competing and challenging requirements―including low electrical contact resistance, high electrochemical stability, good wet adhesion, and low costs―by modifying the electrostatic interaction between the anionic silica particles and cationic polymer layer and by selecting the appropriate number of polymer/silica bilayers. Three hydrophilic degradation mechanisms are observed in FC stacks―dissolution, adhesion, and contamination. It’s unclear whether superhydrophilicity can be maintained throughout a 10-year stack life, particularly with respect to contamination robustness.
Real-Time Microseismic Monitoring of Simultaneous Hydraulic Fracturing Treatments in Adjacent Horizontal Wells in the Woodford Shale (2009)

Introduction The commercial success of horizontal wells drilled in shale-gas reservoirs depends upon the ability to initiate multiple parallel fractures, and/or the presence of complex networks of natural fractures that are connected by induced hydraulic fractures. Production modeling of horizontal well completions shows that recovery might be improved if the distance between parallel hydraulic fractures can be reduced. Simultaneous fracturing of two or more adjacent and parallel horizontal wells has been tested in the Barnett Shale to create hydraulic fracture networks more closely spaced than can be achieved from a single wellbore. Positive results in comparison to wells completed individually were attributed to increased fracture complexity resulting from the interaction of hydraulic fractures initiated in parallel wells. Pressure response while fracturing and radioactive tracer surveys were the primary evaluation tools used. The two previously mentioned references contained an implicit assumption that rock mechanical properties were more or less constant along the length of the horizontal lateral. Evaluation of fracture stimulation treatments in the Barnett Shale that incorporated advanced open-hole logging measurements such as image logs, and borehole-based microseismic monitoring, showed that fracture geometry can be influenced greatly by changes in rock properties along the length of the lateral. The implications of such heterogeneity cannot be ignored when transferring technology from the Barnett Shale to other gas-shale reservoirs. In this paper, we present the results of a microseismic monitoring campaign undertaken as part of a drilling and completion program in the Woodford Shale of south-central Oklahoma that included both single-well and simultaneous fracturing treatments. Two project areas, designated Eastern and Western were selected for live microseismic monitoring during fracturing operations. The project began with a single-well completion in May, 2007 in the Eastern project area. In April, 2008, a four-well simultaneous fracturing treatment was performed in the Western project area. The Eastern project area was finished in June, 2008 and included re-stimulation of the first well completed in May, 2007, a two-well simultaneous fracturing treatment, and the completion of a single well. All treatments were monitored with borehole-based
Distributed-Raman-amplification effect on pulse interactions and collisions in long-haul dispersion-managed soliton transmissions (2002)

We study the effect of distributed Raman amplification on strongly dispersion-managed soliton interactions and collisions in N×20 Gbit/s wavelength-division-multiplexed long-haul transmissions. The measured reduction of noise accumulation with Raman amplification permits determination of the allowable reduction of signal power, when compared with the case of lumped erbium-doped fiber amplifiers. Hence we analytically estimate the reduction of intrachannel interactions and interchannel collisions induced by distributed Raman amplification and evaluate the corresponding decrease of timing jitter.
Technical Note. Do Arterial Phase Helical CT Images Improve Detection or Characterization of Colorectal Liver Metastases? (1997)

Our goal was to determine if arterial phase images from dual phase helical CT improve either the detection or the characterization of hepatic metastases in patients with colorectal carcinoma. Sixty-two patients with known colorectal cancer underwent 65 dual phase helical CT examinations to evaluate for possible liver metastases. Three blinded reviewers independently evaluated the portal venous phase images alone to determine if hepatic metastases were present or absent. Arterial phase images were then analyzed to determine if they identified additional lesions or aided in characterizing small hepatic lesions. Scores of the two methods for diagnosing metastases were compared with the "gold standard" established by a consensus panel of three other radiologists who reviewed all images together with clinical, pathologic, and other imaging data. The addition of arterial phase imaging did not detect any new metastases. However, in 6 of the 64 technically adequate examinations, hepatic arterial phase images increased lesion conspicuity and significantly increased diagnostic confidence when compared with portal vein phase scans alone. In patients with colorectal cancer, the addition of arterial phase imaging does not increase sensitivity, but improves the specificity in diagnosing liver metastases in a small number of cases. Dual phase helical CT does not appear to be indicated in the evaluation of liver metastases from colorectal cancer.
Distributed abstraction and verification of an installed optical fibre network (2021)

The management of wavelength routed optical mesh networks is complex with many potential light path routes and numerous physical layer impairments to transmission performance. This complexity can be reduced by applying the ideas of abstraction from computer science where different equipment is described in the same basic terms. The noise-to-signal ratio can be used as a metric to describe the quality of transmission performance of a signal propagated through a network element and accumulates additively through a sequence of such elements allowing the estimation of end-to-end performance. This study aims to explore the robustness of the noise-to-signal ratio metric in an installed fibre infrastructure. We show that the abstracted noise-to-signal ratio is independent of the observers and their location. We confirm that the abstracted noise-to-signal ratio can reasonably predict the performance of light-paths subsequently set in our network. Having a robust network element abstraction that can be incorporated into routeing engines allows the network management controller to make decisions on the most effective way to use the network resources in terms of the routeing and data coding format.
Antenna cancellation for simultaneous cognitive radio communication and sensing (2013)

Concurrent communication and sensing is a vital cognitive radio (CR) functionality for real-time and accurate monitoring of the radio spectrum that totally depends on the ability of isolating the communication path from the sensing path to a level which ensures that the local transmissions do not overload the sensing unit. Upon discussing the basic challenges that restrain CR from simultaneously sensing the spectrum while transmitting in the same band, the paper presents a novel antenna cancellation approach that promises to empower CRs with concurrent transmission and sensing capabilities. The idea is to equip the CR with redundant transmit antennas to form a spatial filter that selectively cancels the transmit signal in the sensing direction. Such antenna cancellation resulted in an isolation level of 60dB that can be further increased when combined with active power cancellation in the RF or baseband stage.
Addition of zinc homoenolates to acetylenic esters and amides: a formal [3 + 2] cycloaddition (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAddition of zinc homoenolates to acetylenic esters and amides: a formal [3 + 2] cycloadditionMichael T. Crimmins, Philippe G. Nantermet, B. Wesley Trotter, Isabelle M. Vallin, Paul S. Watson, Lynne A. McKerlie, Tracy L. Reinhold, Adrian Wai Hing Cheung, Katherine A. Stetson, and Cite this: J. Org. Chem. 1993, 58, 5, 1038–1047Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/jo00057a013https://doi.org/10.1021/jo00057a013research-articleACS PublicationsRequest reuse permissionsArticle Views687Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
N-Acylthiadiazolines, a New Class of Liver X Receptor Agonists with Selectivity for LXRβ (2007)

We have identified a novel liver X receptor (LXR) agonist (2) that activates the LXRbeta subtype with selectivity over LXRalpha. LXRbeta selectivity was confirmed using macrophages derived from LXR mutant mice. Despite its selectivity and modest potency, the compound can induce APO-AI-dependent cholesterol efflux from macrophages with full efficacy. Our results indicate that it is possible to achieve significant LXRbeta selectivity in a small molecule while maintaining functional LXR activity.
Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM (2021)

ABSTRACT Restriction enzymes that combine DNA methylation and cleavage activities into a single polypeptide or protein assemblage and that modify just one DNA strand for host protection are capable of more efficient adaptation towards novel target sites. However, they must solve the problem of discrimination between newly replicated and unmodified host sites (needing methylation) and invasive foreign site (needing to lead to cleavage). One solution to this problem might be that the activity that occurs at any given site is dictated by the oligomeric state of the bound enzyme. Methylation requires just a single bound site and is relatively slow, while cleavage requires that multiple unmethylated target sites (often found in incoming, foreign DNA) be brought together into an enzyme-DNA complex to license rapid cleavage. To validate and visualize the basis for such a mechanism, we have determined the catalytic behavior of a bifunctional Type IIL restriction-modification (‘RM’) enzyme (DrdV) and determined its high-resolution structure at several different stages of assembly and coordination with multiple bound DNA targets using CryoEM. The structures demonstrate a mechanism of cleavage by which an initial dimer is formed between two DNA-bound enzyme molecules, positioning the single endonuclease domain from each enzyme against the other’s DNA and requiring further oligomerization through differing protein-protein contacts of additional DNA-bound enzyme molecules to enable cleavage. The analysis explains how endonuclease activity is licensed by the presence of multiple target-containing DNA duplexes and provides a clear view of the assembly through 3D space of a DNA-bound RM enzyme ‘synapse’ that leads to rapid cleavage of foreign DNA.
Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial (2020)

Tocilizumab reduced lethality rate at 30 days compared with null hypothesis, without significant toxicity. Possibly, this effect could be limited to patients not requiring mechanical respiratory support at baseline. Registration EudraCT (2020-001110-38); clinicaltrials.gov (NCT04317092).
ChemInform Abstract: Antitubercular Potential of Plants: A Brief Account of Some Important Molecules (2010)

Abstract Review: 102 refs.
Molecular Cytogenetic Delineation of Deletions and Translocations Involving Chromosome Band 7q22 in Myeloid Leukemias (1997)

Loss of chromosome 7 (-7) or deletion of its long arm (7q-) are recurring chromosome abnormalities in myeloid disorders, especially in therapy-related myelodysplastic syndrome (t-MDS) and acute myeloid leukemia (t-AML). The association of -7/7q- with myeloid leukemia suggests that these regions contain a novel tumor suppressor gene(s) whose loss of function contributes to leukemic transformation or tumor progression. Based on chromosome banding analysis, two critical regions have been identified: one in band 7q22 and a second in bands 7q32-q35. We analyzed bone marrow and blood samples from 21 patients with myeloid leukemia (chronic myeloid leukemia, n = 2; de novo MDS, n = 4; de novo AML, n = 13; t-AML, n = 2) that on chromosome banding analysis exhibited deletions (n = 19) or reciprocal translocations (n = 2) of band 7q22 using fluorescence in situ hybridization. As probes, we used Alu-polymerase chain reaction products from 22 yeast artificial chromosome (YAC) clones that span chromosome bands 7q21.1-q32, including representative clones from a panel of YACs recognizing a contiguous genomic DNA fragment of 5 to 6 Mb in band 7q22. In the 19 cases with deletions, we identified two distinct commonly deleted regions: one region within band 7q22 was defined by the two CML cases; the second region encompassed a distal part of band 7q22 and the entire band 7q31 and was defined by the MDS/AML cases. The breakpoint of one of the reciprocal translocations was mapped to 7q21.3, which is centromeric to both of the commonly deleted regions. The breakpoint of the second translocation, which was present in unstimulated bone marrow and phytohemagglutinin-stimulated blood of an MDS patient, was localized to a 400-kb genomic segment in 7q22 within the deletion cluster of the MDS/AML cases. In conclusion, our data show marked heterogeneity of 7q22 deletion and translocation breakpoints in myeloid leukemias, suggesting the existence of more than one pathogenetically relevant gene.
Dry Development Rinse Process (DDRP) and material (DDRM) for novel pattern collapse free process (2016)

Because the pattern pitch is getting smaller and smaller, the pattern collapse issue in the lithography process have been getting the sever problem. Especially, pattern collapse is one of the main reasons for minimizing of process margin at fine pitch by EUV lithography. The possible major cause of pattern collapse is the surface tension of the rinsing liquid and the shrinkage of resist pattern's surface in the process of drying the rinsing liquid. The influence of surface tension for very small pitch pattern is particularly severe. The one of the most effective solution for this problem is thinning of the resist film thickness, however this method is reaching to its limits in terms of substrate etching process anymore. The tri-layer resist process or hard mask processes have been used, but there is a limit to the thinning of resist film and there is no essential solution for this problem. On the other hand, the supercritical drying method has been known as an ultimate way to suppress the pattern collapse issue. The supercritical drying method is a dry process advanced to the vapor phase from the liquid phase via supercritical, and the supercritical drying method can dry the rinsing liquid without making the vapor-liquid coexistence state. However, this process is not applied to the mass production process because it requires the introduction of the special equipment. We newly developed the novel process and material which can prevent the pattern collapse issue perfectly without using any special equipment. The process is Dry Development Rinse Process (DDRP), and the material used in the process is Dry Development Rinse Material (DDRM). DDRM is containing the special polymer which can replace the exposed and developed part. And finally, the resist pattern will be developed by Dry etching process without any pattern collapse issue. In this paper, We will discuss the approach for preventing the pattern collapse issue in PTD and NTD process, and propose DDRP and DDRM as the solution.
Wavelength dependence of boron nitride ablation by TEA CO2 lasers (1996)

Transversely excited atmospheric (TEA) CO2 laser ablation of boron nitride ceramics in both cubic and hexagonal phases (cBN, hBN) was demonstrated. A TEA CO2 laser oscillating at a wavelength of 9.2 μm, which coincides with a TO‐phonon spectrum of the cBN, could ablate the cBN ceramics more efficiently than with 10 μm band radiation. The hBN samples were also ablated well with 9.2 μm laser irradiation, however, the ablated site color changed to black due to a boron rich phase left on the surface. In the case of hBN sintered with Al2O3 and SiO2, the ablation threshold fluence is determined by the one of Al2O3, which is the highest threshold among the three elements.
Intelligence on top of the networks: SIP based service control layer signaling (2002)

In order to support the integration of heterogeneous networks and diverse access devices, we have developed a server architecture that provides integrated telecommunications and data services spanning heterogeneous networks. The server architecture interfaces to the networks via adaptation units to provide a network independent service control on top of the networks. We have structured the architecture according to the principles of the TINA service architecture in a user control part, a service control part and a communication control part. We have adopted the IETF session initiation protocol (SIP) to serve as a service control layer signaling protocol. Our session control protocol (SesCP) supports the setup and control of complex multimedia communication services and provides flexibility in order to support a wide range of new services. In particular, SesCP provides signaling mechanisms that support different levels of the service description, starting with the service called 'called-by-name' and finally coming to a precise connection description that is realized in the networks. SesCP also supports the negotiation of service description parameters.
Propylene Polymerization with α-Keto-β-Diimine Initiators Proceeds via Enantiomorphic Site Control (2012)

13C NMR spectroscopy is used to characterize the microstructure of polypropylene (PP) obtained using a nickel α-keto-β-diimine initiator activated with methylaluminoxane (MAO) at different reaction temperatures (Trxn). The product prepared at −20 °C has structural features that resemble an ethylene-propylene copolymer. We find that the main sequences present in this sample arise as a result of normal 1,2-insertion and that propylene sequences are predominantly isotactic (m = 88%, mmmm = 63%). There is also evidence of ethylene-like sequences as a result of 3,1-enchainment, and from 2,1-insertion. A reduction in Trxn to −60 °C results in a polymer that has undetectable regioirregularities and is highly isotactic (m = 93%, mmmm = 85%). Moreover, the application of stereo propagation models gives indication that the isospecificity is a result of enantiomorphic site control.