gebhart/patrepeval huggingface dataset:
Electrochemically deposited polythiophene. 1. Ohmic drop compensation and the polythiophene paradox (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemically deposited polythiophene. 1. Ohmic drop compensation and the polythiophene paradoxMiklos. Gratzl, Duan Fu. Hsu, Andrew M. Riley, and Jiri. JanataCite this: J. Phys. Chem. 1990, 94, 15, 5973–5981Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/j100378a066https://doi.org/10.1021/j100378a066research-articleACS PublicationsRequest reuse permissionsArticle Views405Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
An Optical Approach for Drug Screening Based on Light‐Harvesting Conjugated Polyelectrolytes (2009)

Abstract Wirkstoffe schalten das Licht aus : Konjugierte Polyelektrolyte (CPEs) wurden in Fluoreszenzassays zum Echtzeit‐Screening von niedermolekularen Verbindungen genutzt (siehe Bild), welche die für die virale Replikation wichtige RNA‐Protein‐Komplexierung verhindern und damit als Kandidaten für die weitere Wirkstoffentwicklung dienen können. magnified image
A scalable algorithm for clustering protein sequences (2001)

The enormous growth of public sequence databases and continuing addition of fully sequenced genomes has created many challenges in developing novel and scalable computational techniques for searching, comparing, and analyzing these databases. Over the years, many methods have been developed for clustering proteins according to their sequence similarity. However, most of these methods tend to have a computational complexity that is at least quadratic on the number of sequences. In this paper we present an entirely dierent approach to protein clustering that does not require an all-against-all analysis and uses a near-linear complexity K-means based clustering algorithm. Our experimental evaluation on three dierent data sets containing up to 43,569 protein sequences, show that this approach leads to reasonably good clusters.
Photodynamic therapy for locally advanced pancreatic cancer: early clinical results (2010)

Pancreatic adenocarcinoma ranks as the fourth most common cause of cancer death in the USA. Patients usually present late with advanced disease, limiting attempted curative surgery to 10% of cases. Overall prognosis is poor with one-year survival rates of less than 10% with palliative chemotherapy and/or radiotherapy. Given these dismal results, a minimally invasive treatment capable of local destruction of tumor tissue with low morbidity may have a place in the treatment of this disease. In this paper we review the preclinical photodynamic therapy (PDT) studies which have shown that it is possible to achieve a zone of necrosis in normal pancreas and implanted tumour tissue. Side effects of treatment and evidence of a potential survival advantage are discussed. We describe the only published clinical study of pancreatic interstitial PDT, which was carried out by our group (Bown et al Gut 2002), in 16 patients with unresectable locally advanced pancreatic adenocarcinoma. All patients had evidence of tumor necrosis on follow-up imaging, with a median survival from diagnosis of 12.5 months. Finally, we outline a phase I dose-escalation study of verteporfin single fibre PDT followed by standard gemcitabine chemotherapy which our group is currently undertaking in patients with locally advanced pancreatic cancer. Randomized controlled studies are also planned.
Effect of Nanofiller Characteristics on Nanocomposite Properties (2016)

This report surveys the effect of nanofiller characteristics on nanocomposites fabricated with two polyimide matrices. Mechanical and electrical properties were determined. Microscopy results showed that matrix chemistry, nanofiller characteristics and processing conditions had significant impact on nanocomposite quality.
Shale Wettability and Influencing Factors: A Statistical Investigation (2022)

Predicting the wetting behavior of shale rocks is important for understanding fluid flow in shales for CO2 geo-storage and enhanced oil recovery applications. However, shale rocks tend to demonstrate a much wider wettability variation compared to conventional rocks. Here, we present a new model for predicting advancing and receding contact angles for shale/CO2/brine systems. The model presented here considers shale wettability variation as a function of key influencing parameters including (a) operating conditions (i.e., pressure, temperature, and salinity), (b) shale total organic carbon (TOC), (c) thermal maturity, and (d) mineralogy of shale (including quartz, calcite, dolomite, clay, and pyrite content). The developed model shows that pressure and salinity are the most influencing parameters for both the advancing and receding contact angles. These are followed by temperature, TOC, and thermal maturity. The results of this study contribute toward predicting the wetting behavior of shale with known operating and functional properties and thus serve as an essential input in simulation models pertinent to flow behavior in shale rocks and therefore enhance hydrocarbon production from shales and CO2 storage in shale formations.
Abstract 4571: 515H7, a novel anti-CXCR4 antibody: In vitro efficacy on CXCR4-associated signaling pathways and in vivo anti-tumor activity (2011)

Abstract Chemokines are small, secreted peptides that control the migration of leukocytes along a chemical gradient of ligand, especially during immune and inflammatory reactions. They are divided into two major subfamilies, CC and CXC, based on the position of their NH2-terminal cysteine residues, and bind to G protein coupled receptors, whose two major sub families are designated CCR and CXCR. More than 50 human chemokines and 18 chemokine receptors have been discovered so far. Chemokine receptor CXCR4/[Stromal cell-derived factor (SDF)-1] axis plays a central role in various physiological and pathological processes, including cancer. CXCR4 is over-expressed in a large number of tumors: colon, breast, prostate, lung, ovary, pancreas. CXCR4/SDF-1 axis is directly implicated in migration, invasion leading to metastases, cell proliferation and angiogenesis. Moreover, CXCR4 overexpression correlated with poor prognosis in many types of cancer. A novel monoclonal antibody (Mab 515H7) was raised against the human CXCR4. It displayed efficacious antagonist properties for all major pathways associated with SDF-1-induced CXCR4 signaling in vitro. It was able to efficiently bind CXCR4 on both transfected cells and human tumor cell lines. It was found to strongly inhibit SDF-1 binding, Gα protein activation and beta-arrestin2 recruitment. It also blocked second messenger release (calcium, cAMP) and constrained by itself the formation of CXCR4 homodimers. It also inhibits SDF-1-induced cell migration in vitro. 515H7 Mab antitumor activities were also investigated in vivo using several human tumor models. We demonstrated that 515H7 Mab was able to significantly inhibit growth of xenograft tumors in mice. In addition to its effect on tumor growth, 515H7 Mab was also able to significantly improve mice survival in the lethal U937 model. The herewith data demonstrate that Mab 515H7 behaves as a potent and efficacious antagonist of all major CXCR4-controlled signaling pathways and suggest that targeting CXCR4 is a promising way for the treatment of tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4571. doi:10.1158/1538-7445.AM2011-4571
Single-substrate IPS-LCD using an anisotropic polymer film (2005)

Most liquid crystal display (LCD) devices use two ITO-glass substrates in order to confine the fluidic LC. To align the LC molecules, the inner surfaces of the substrates were coated with a thin polyimide (PI) layer. These PI layers are mechanically buffed in order to produce uniform molecular alignment. To reduce weight, the single-substrate approach has been explored recently in which the LC device consists of a substrate and a thin polymer film. The major technical challenge is how to align the LC molecules on the polymer film side. In this paper, we demonstrate a new single-substrate IPS-LCD. The LC cell consists of an anisotropic LC polymer film and an interdigitated ITO-glass substrate. The anisotropic film not only behaves as a substrate but also helps align the LC molecules. Compared to the LCD using two glass substrates, the new device has almost the same bright state and the same dark state. Our new device exhibits a higher contrast ratio (~514:1) because of good LC alignment. The driving voltage is low, and the response time is reasonably fast. The measured rise time is ~8ms and decay time is ~63 ms using a 12-&mu;m cell gap and E7 LC mixture. This technology is particularly attractive for making single-substrate displays and also has potential for a double-layered guest-host display and a flexible display using IPS LCDs.
Exploring Substrate Scope ofShi-Type Epoxidations (2008)

Enantioselective epoxidations of alkenes (12 examples) were achieved using a Shi-type carbohydrate-derived hydrate and Oxone. The chiral platform provided by the catalyst tolerates a wide range of substituents providing high yields and enantioselectivities (80-95.5% ee). However, styrene derivatives were only converted with poor selectivities (11-26% ee).
Transmission of 200G PM-16QAM Subcarriers with Reduction of Penalty from Linear Crosstalk Using Super-Nyquist Filtering and Low Complexity MMSE (2017)

We improved the tolerance to linear crosstalk of 34GHz-spaced 272Gb/s PM-16QAM subcarriers by 0.5dB after 480km SSMF transmission, using Super-Nyquist Filtering and low complexity MMSE-based ISI compensation, compared to Nyquist shaping at identical circuit resource.
The design optimization of miniature low profile antennas placed in close proximity to high-impedance surfaces (2004)

The objective of the paper is to illustrate a new design optimization procedure for miniaturized antennas placed near a high-impedance surface, i.e., a perfect magnetic conductor (PMC). It is demonstrated that antennas can be optimized via a genetic algorithm (GA) to achieve superior performance characteristics (e.g., input impedance, VSWR, and gain) when placed in close proximity to a PMC ground plane as opposed to a standard perfect electric conductor (PEC) ground plane. A methodology that allows for the compensation of the coupling effects is introduced; it is based on optimizing the shape of a miniaturized fractal or stochastic antenna placed next to a PMC surface. It is also demonstrated that these genetically optimized antennas exhibit superior performance when compared to conventional half-wave dipoles with the same design specifications. Several case studies are presented that compare the performance of specific antennas when operating near PMC and PEC ground planes. It is shown that, in the case of a PMC ground plane, the desired VSWR specifications can be achieved by optimizing the geometries of fractal or stochastic antennas. This technique can be used to design miniature low-profile antennas successfully. We also illustrate the fact that it is not possible to achieve similar results using a conventional PEC ground plane.
Mobile Plug-and-Play Architecture for Collaborative Hybrid Peer-to-Peer Applications (2008)

Increasing heterogeneity of networks, services and applications emphasizes the need for middleware as an essential part of the information technology infrastructure. To implement novel 3G and beyond 3G mobile applications and services, the light-weight middleware utilizing application supernetworking- and hybrid peer-to-peer (P2P) - client/server concepts can be considered. Application supernetworking means collaboration of applications that utilize a set of common functionalities for sharing contextual information and managing sessions and connectivities. Hybrid P2P - client/server concept aims to optimize the network system features by exploiting the advantages of both the P2P and client/server domains. Hybrid scenarios could include e.g. utilizing secure client/server -based authentication for P2P networks. We have developed a plug-and-play application platform (PnPAP) mobile middleware to support novel application development and improved user experience. PnPAP provides support for seamless usage of multiple simultaneous applications, protocols and network connectivities. Required user interaction is reduced and new collaborative application scenarios, utilizing both P2P- client/server networks, are enabled. For the application developers, PnPAP enables faster development cycle by providing a unified API definition for protocol, session and connectivity management. Functionalities of the PnPAP core are controlled with state-machines, where the rules of operation can be dynamically updated over-the-air by the service provider. This enables managing the heterogeneity in a more flexible way than in the traditional systems given in this document.
SYS6: Tenet: An Architecture for Tiered Embedded Networks (2005)

Over the last five years, sensor network research has seen significant advances in the development of hardware devices and platforms, and in the design of services and infrastructural elements such as routing, localization, and time synchronization. Deployed systems, however, have lagged behind. In this poster, we will describe an alternative architecture, called Tenet, for sensor networks that constrains placement of application-specific functionality on relatively unconstrained nodes. We will then briefly describe our experiences with an early prototype system built on this architecture.
Exact solution for the conditional entropy of Poissonian LDPC codes over the Binary Erasure Channel (2007)

We consider communication over a binary erasure channel with low density parity check codes and optimal maximum a posteriori decoding. It is known that the problem of computing the average conditional entropy, over such code ensembles, in the asymptotic limit of large block length is closely related to computing the free energy of a mean field spin glass in the thermodynamic limit. Tentative, but explicit, formulas for these quantities have been derived thanks to the replica method (of spin glass theory) and are generally conjectured to be exact. In this contribution we show that the replica formulas are indeed exact in the case of Poissonian low density parity check ensembles. Our methods use ideas coming from the recent progress in the rigorous analysis of the Sherrington-Kirkpatrick model and their applications to the theory of error correcting codes.
Direct catalytic conversion of cellulose to liquid straight-chain alkanes (2014)

A novel one-pot catalytic approach is presented that is able to directly transform cellulose into straight-chain alkanes (mainly <italic>n</italic>-hexane).
An Enzymatic Toolkit for Selective Proteolysis, Detection, and Visualization of Mucin-Domain Glycoproteins (2020)

&lt;p&gt;Densely O-glycosylated mucin domains are found in a broad range of cell surface and secreted proteins, where they play key physiological roles. In addition, alterations in mucin expression and glycosylation are common in a variety of human diseases, such as cancer, cystic fibrosis, and inflammatory bowel diseases. These correlations have been challenging to uncover and establish because tools that specifically probe mucin domains are lacking. Here, we present a panel of bacterial proteases that cleave mucin domains via distinct peptide- and glycan-based motifs, generating a diverse enzymatic toolkit for mucin-selective proteolysis. By mutating catalytic residues of two such enzymes, we engineered mucin-selective binding agents with retained glycoform preferences. StcE&lt;sup&gt;E447D&lt;/sup&gt; is a pan-mucin stain derived from enterohemorrhagic &lt;i&gt;Escherichia coli &lt;/i&gt;that is tolerant to a wide range of glycoforms. BT4244&lt;sup&gt;E575A&lt;/sup&gt; derived from &lt;i&gt;Bacteroides thetaiotaomicron&lt;/i&gt; is selective for truncated, asialylated Core 1 structures commonly associated with malignant and pre-malignant tissues. We demonstrated that these catalytically inactive point mutants enable robust detection and visualization of mucin-domain glycoproteins by flow cytometry, Western blot, and immunohistochemistry. Application of our enzymatic toolkit to ovarian cancer patient ascites fluid and tissue slices facilitated characterization of patients based on differences in mucin cleavage and expression patterns.&lt;/p&gt;
Confocal laser scanning microscopy image correlation for nanoparticle flow velocimetry (2016)

We present a new particle image correlation technique for resolving nanoparticle flow velocity using confocal laser scanning microscopy (CLSM). The two primary issues that complicate nanoparticle scanning laser image correlation (SLIC) based velocimetry are (1) the use of diffusion dominated nanoparticles as flow tracers, which introduce a random decorrelating error into the velocity estimate, and (2) the effects of the scanning laser image acquisition, which introduces a bias error. To date, no study has quantified these errors or demonstrated a means to deal with them in SLIC velocimetry. In this work, we build upon the robust phase correlation (RPC) and existing methods of SLIC to quantify and mitigate these errors. First, we implement an ensemble RPC instead of using an ensemble standard cross correlation, and develop an SLIC optimal filter that maximizes the correlation strength in order to reliably and accurately detect the correlation peak representing the most probable average displacement of the nanoparticles. Secondly, we developed an analytical model of the SLIC measurement bias error due to image scanning of diffusion dominated tracer particles. We show that the bias error depends only on the ratio of the mean velocity of the tracer particles to that of the laser scanner and we use this model to correct the induced errors. We validated our technique using synthetic images and experimentally obtained SLIC images of nanoparticle flow through a micro-channel. Our technique reduced the error by up to a factor of ten compared to other SLIC algorithms for the images tested in this study. Moreover, our optimized RPC filter is reducing the number of image pairs required for the convergence of the ensemble correlation by two orders of magnitude compared to the standard cross correlation.
Advanced 3D-confocal microscopy of cleared mouse bones reveals the architecture and quantitative interrelationship of the stromal and vascular compartments in bone (2020)

status: Published
Atomic and Electrical Characterisation of Amorphous Silicon Passivation Layers (2012)

In this work, an extensive characterisation of intrinsic amorphous silicon (a-Si) passivation layers deposited on n- and p-type silicon is reported. Low temperature capacitance-voltage measurements are utilised to enable parameter extraction from the c-Si/a-Si interface and a-Si bulk. Electron spin resonance enables atomic identification of defects present. Results reveal the presence of electrically active defects at the c-Si/intrinsic a-Si interface (∼1x1012 cm-2), and throughout the amorphous silicon layer bulk (∼8x1016 cm-3), which are atomically identified as Pb0 centres and D centres silicon dangling bond defects, respectively. The value of this work is the atomic identification of these defects in this stack, coupled with their electrical activity. That they can be detected by these techniques demonstrates the power of the methodology used to assess and quantify these defects. Therein lies the significance of this work: a methodology capable of fundamentally optimising amorphous silicon processing from an atomic perspective.
Structure of the Archaeal Pab87 Peptidase Reveals a Novel Self-Compartmentalizing Protease Family (2009)

Self-compartmentalizing proteases orchestrate protein turnover through an original architecture characterized by a central catalytic chamber. Here we report the first structure of an archaeal member of a new self-compartmentalizing protease family forming a cubic-shaped octamer with D(4) symmetry and referred to as CubicO. We solved the structure of the Pyrococcus abyssi Pab87 protein at 2.2 A resolution using the anomalous signal of the high-phasing-power lanthanide derivative Lu-HPDO3A. A 20 A wide channel runs through this supramolecular assembly of 0.4 MDa, giving access to a 60 A wide central chamber holding the eight active sites. Surprisingly, activity assays revealed that Pab87 degrades specifically d-amino acid containing peptides, which have never been observed in archaea. Genomic context of the Pab87 gene showed that it is surrounded by genes involved in the amino acid/peptide transport or metabolism. We propose that CubicO proteases are involved in the processing of d-peptides from environmental origins.
Covalent Virus Layer for Mass-Based Biosensing (2008)

M13 virus particles were covalently attached to a planar gold-coated quartz crystal microbalance (QCM) through reaction with a self-assembled monolayer of N-hydroxysuccinimide thioctic ester, followed by incorporation of the blocking agent bovine serum albumin. This immobilization chemistry produced a phage multilayer having a coverage equivalent to approximately 6.5 close-packed monolayers of the virus. The properties of this "covalent virus surface" or CVS for the mass-based detection of a 148.2 kDa antibody were then evaluated in a phosphate buffer using a flow injection analysis system. The mass of the CVS increased with exposure to an antibody (p-Ab) known to bind the phage particles with high affinity. Bound p-Ab was removed by washing with 0.5 M HCl thereby regenerating the sensor surface. A calibration plot for p-Ab binding was constructed by repetitively exposing the surface to p-Ab at concentrations between 6.6 and 200 nM and HCl rinsing after each exposure. The mass-concentration relationship was linear with a sensitivity of 0.018 microg/(cm2 nM) and a limit of detection of 7 nM or 1.3 pmol. The CVS could be saturated with high doses of p-Ab enabling the determination that an average of approximately 140 binding sites are available per M13 phage particle. Exposure of the CVS to a second, nonbinding antibody (n-Ab) did not cause a measurable mass change. These results demonstrate that the covalent virus layer is a rugged, selective, and sensitive means for carrying out mass-based biodetection.