gebhart/patrepeval huggingface dataset:
Sequence of the seed lectin gene from pea (Pisum sativumL.) (1987)

Journal Article Sequence of the seed lectin gene from pea ( Pisum sativum L.) Get access John A. Gatehouse, John A. Gatehouse * Department of Botany, Durham UniversitySouth Road, Durham DH1 3LE, UK * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar David Bown, David Bown Department of Botany, Durham UniversitySouth Road, Durham DH1 3LE, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar I.Marta Evans, I.Marta Evans Department of Botany, Durham UniversitySouth Road, Durham DH1 3LE, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Laurence N. Gatehouse, Laurence N. Gatehouse Department of Botany, Durham UniversitySouth Road, Durham DH1 3LE, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar David Jobes, David Jobes Department of Botany, Durham UniversitySouth Road, Durham DH1 3LE, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul Preston, Paul Preston Department of Botany, Durham UniversitySouth Road, Durham DH1 3LE, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Ronald R.D. Croy Ronald R.D. Croy Department of Botany, Durham UniversitySouth Road, Durham DH1 3LE, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 15, Issue 18, 25 September 1987, Page 7642, https://doi.org/10.1093/nar/15.18.7642 Published: 25 September 1987 Article history Received: 05 August 1987 Published: 25 September 1987
NF-κB-responsive miR-155 induces functional impairment of vascular smooth muscle cells by downregulating soluble guanylyl cyclase (2019)

Vascular smooth muscle cells (VSMCs) play an important role in maintaining vascular function. Inflammation-mediated VSMC dysfunction leads to atherosclerotic intimal hyperplasia and preeclamptic hypertension; however, the underlying mechanisms are not clearly understood. We analyzed the expression levels of microRNA-155 (miR-155) in cultured VSMCs, mouse vessels, and clinical specimens and then assessed its role in VSMC function. Treatment with tumor necrosis factor-α (TNF-α) elevated miR-155 biogenesis in cultured VSMCs and vessel segments, which was prevented by NF-κB inhibition. MiR-155 expression was also increased in high-fat diet-fed ApoE<sup>-/-</sup> mice and in patients with atherosclerosis and preeclampsia. The miR-155 levels were inversely correlated with soluble guanylyl cyclase β1 (sGCβ1) expression and nitric oxide (NO)-dependent cGMP production through targeting the sGCβ1 transcript. TNF-α-induced miR-155 caused VSMC phenotypic switching, which was confirmed by the downregulation of VSMC-specific marker genes, suppression of cell proliferation and migration, alterations in cell morphology, and NO-induced vasorelaxation. These events were mitigated by miR-155 inhibition. Moreover, TNF-α did not cause VSMC phenotypic modulation and limit NO-induced vasodilation in aortic vessels of miR-155<sup>-/-</sup> mice. These findings suggest that NF-κB-induced miR-155 impairs the VSMC contractile phenotype and NO-mediated vasorelaxation by downregulating sGCβ1 expression. These data suggest that NF-κB-responsive miR-155 is a novel negative regulator of VSMC functions by impairing the sGC/cGMP pathway, which is essential for maintaining the VSMC contractile phenotype and vasorelaxation, offering a new therapeutic target for the treatment of atherosclerosis and preeclampsia.
Tuning cationic composition of La:EuTiO3−δ films (2013)

Eu1−xLaxTiO3−δ (x = 0, 0.3, 0.5) films were deposited in a p(Ar(96%)/H2(4%)) = 4 × 10−4 mbar atmosphere on (LaAlO3)0.3-(Sr2AlTaO6)0.7 vicinal substrates (0.1°). Reflection high-energy electron diffraction oscillation characteristics of a layer-by-layer growth mode were observed for stoichiometric and Ti-rich films and the laser fluence suited to deposit stoichiometric films was identified to be 1.25 J/cm2 independent of the La content. The variety of resulting film compositions follows the general trend of Eu-enrichment for low laser and Ti-enrichment for high laser fluence. X-ray diffraction confirms that all the films are compressively strained with a general trend of an increase of c-axis elongation for non-stoichiometric films. The surfaces of non-stoichiometric films have an increased roughness, the highest sheet resistances, exhibit the presence of islands, and are Eu3+ rich for films deposited at low laser fluence.
Supplemental figure 2 from Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum (2023)

&lt;p&gt;Receiver operator classification curves for lung cancer detection for the genes obtained from sputum&lt;/p&gt;
Universal Design/Design for All: Practice and Method (2008)

This chapter contains sections titled: Introduction Key Tools Universal Design and Aging Methods The Future of Universal Design Conclusions Acknowledgment References
Estimating Accuracy from Unlabeled Data: A Probabilistic Logic Approach (2017)

We propose an efficient method to estimate the accuracy of classifiers using only unlabeled data. We consider a setting with multiple classification problems where the target classes may be tied together through logical constraints. For example, a set of classes may be mutually exclusive, meaning that a data instance can belong to at most one of them. The proposed method is based on the intuition that: (i) when classifiers agree, they are more likely to be correct, and (ii) when the classifiers make a prediction that violates the constraints, at least one classifier must be making an error. Experiments on four real-world data sets produce accuracy estimates within a few percent of the true accuracy, using solely unlabeled data. Our models also outperform existing state-of-the-art solutions in both estimating accuracies, and combining multiple classifier outputs. The results emphasize the utility of logical constraints in estimating accuracy, thus validating our intuition.
Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality (2017)

info:eu-repo/semantics/published
Dynamic Evaluation of New York State’s Aluminum Pedestrian Signal Pole System (2009)

The New York State Department of Transportation (NYSDOT) mounts pedestrian “hand/man” signals to aluminum poles and uses frangible transformer bases to allow the system to break away. However, engineers at NYSDOT believed that the material properties of the aluminum poles themselves would allow the pedestrian signal poles to break away without the use of transformer bases. Elimination of the frangible transformer base would result in significant savings. An aluminum pedestrian signal pole system was erected at the Valmont testing facility and tested with the Valmont- MwRSF/UNL pendulum with crushable nose in accordance with NCHRP Report No. 350 test designation no. 3-60. Upon impact the pole broke away from the base plate assembly, and the surrogate vehicle change in velocity was measured to be 13.9 ft/s (4.2 m/s), satisfying the limit of 16.4 ft/s (5.0 m/s). However, the remaining stub height measured 4.5 in. (114 mm), and violated the 4 in. (100 mm). Thus, the test was deemed unsuccessful. The results from the impact test were used in a numerical analysis to predict the change in velocity for the high-speed impact test, test designation no. 3-61. This analysis showed that the aluminum pedestrian signal pole would also satisfy the occupant risk criteria during a high-speed test. Since the pole cleanly broke away in the test and the high-speed impact analysis showed a satisfactory change in velocity, the excessive stub height was the only result that prevented this installation from becoming crashworthy. As such, three separate design modifications were presented for aiding the system to satisfy the stub maximum height limit.
The LIN-15A and LIN-56 Transcriptional Regulators Interact to Negatively Regulate EGF/Ras Signaling inCaenorhabditis elegansVulval Cell-Fate Determination (2011)

The restricted expression of epidermal growth factor (EGF) family ligands is important for proper development and for preventing cancerous growth in mammals. In Caenorhabditis elegans, the class A and B synthetic multivulva (synMuv) genes redundantly repress expression of lin-3 EGF to negatively regulate Ras-mediated vulval development. The class B synMuv genes encode proteins homologous to components of the NuRD and Myb-MuvB/dREAM transcriptional repressor complexes, indicating that they likely silence lin-3 EGF through chromatin remodeling. The two class A synMuv genes cloned thus far, lin-8 and lin-15A, both encode novel proteins. The LIN-8 protein is nuclear. We have characterized the class A synMuv gene lin-56 and found it to encode a novel protein that shares a THAP-like C(2)CH motif with LIN-15A. Both the LIN-56 and LIN-15A proteins localize to nuclei. Wild-type levels of LIN-56 require LIN-15A, and wild-type levels and/or localization of LIN-15A requires LIN-56. Furthermore, LIN-56 and LIN-15A interact in the yeast two-hybrid system. We propose that LIN-56 and LIN-15A associate in a nuclear complex that inhibits vulval specification by repressing lin-3 EGF expression.
Cell-free microRNAs: potential biomarkers in need of standardized reporting (2013)

MicroRNAs are abundantly present and surprisingly stable in multiple biological fluids. These findings have been followed by numerous reverse transcription real-time quantitative PCR (RT-qPCR)-based reports revealing the clinical potential of using microRNA levels in body fluids as a biomarker of disease. Despite a rapidly increasing body of literature, the field has failed to adopt a set of standardized criteria for reporting the methodology used in the quantification of cell-free microRNAs. Not only do many studies based on RT-qPCR fail to address the Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) criteria but frequently there is also a distinct lack of detail in descriptions of sample source and RNA isolation. As a direct result, it is often impossible to compare the results of different studies, which in turn, hinders progress in the field. To address this point, we propose a simple set of criteria to be used in conjunction with MIQE to reveal the true potential of cell-free microRNAs as biomarkers.
ChemInform Abstract: Synthesis and Unusual Chemical Reactivity of Certain Novel 4,5‐Disubstituted 7‐Benzylpyrrolo[2,3‐d][1,2,3]triazines. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sonochemical Preparation of GaSb Nanoparticles. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hierarchical Nanotube Self‐Assembly of DNA Minor Groove‐Binding Ligand DB921 via Alkali Halide Triggering (2019)

A systematic study into a novel self‐assembling system is presented whereby the small molecule DB921 forms nearly monodisperse nanotubes upon addition of a suitable salt. Small‐angle X‐ray scattering and negative stain transmission electron microscopy are employed as the principal characterization methods to study both the fundamental assembly processes and reaction kinetics. The assembly is found to be hierarchical, culminating with helical winding of intermediate ribbon structures into nanotubes. The driving force for this process is likely the electrostatic interaction between DB921 and salt anions; this aspect can be used to control nanotube assembly and morphology.
ChemInform Abstract: AZO ANIONS IN SYNTHESIS. USE OF TRITYL‐ AND DIPHENYL‐4‐PYRIDYLMETHYLHYDRAZONES FOR REDUCTIVE CARBON‐CARBON BOND FORMATION FROM ALDEHYDES AND KETONES (1984)

Abstract Die aus den Tritylhydrazonen (III) erhaltenen Lithiumverbindungen (IV) lassen sich gemäß Formelschema in Kohlenwasserstoffe (V), Alkohole (VI) bzw. Alkene (VII) umwandeln.
A Birman-Schwinger Principle in General Relativity: Linearly Stable Shells of Collisionless Matter Surrounding a Black Hole (2022)

We develop a Birman-Schwinger principle for the spherically symmetric, asymptotically flat Einstein-Vlasov system. It characterizes stability properties of steady states such as the positive definiteness of an Antonov-type operator or the existence of exponentially growing modes in terms of a one-dimensional variational problem for a Hilbert-Schmidt operator. This requires a refined analysis of the operators arising from linearizing the system, which uses action-angle type variables. For the latter, a single-well structure of the effective potential for the particle flow of the steady state is required. This natural property can be verified for a broad class of singularity-free steady states. As a particular example for the application of our Birman-Schwinger principle we consider steady states where a Schwarzschild black hole is surrounded by a shell of Vlasov matter. We prove the existence of such steady states and derive linear stability if the mass of the Vlasov shell is small compared to the mass of the black hole.
Retroreflector diffraction modeling (1998)

The SIM metrology subsystem utilizes cornercube retroreflectors as fiducials. These components will introduce errors in the metrology output that must be quantified. Eventually, a complete modeling of the metrology subsystem will be needed. For that purpose, we are developing an optical model for a cornercube retroreflector, taking into account most of the defects present in such an optical part. Our goal is to given a phase map of the wavefront produced by the interference of the reference beam and the metrology beam. Our first step towards this goal is the construction of an optical model and its validation, using the MACOS and VSIM packages.
Analysis of Hydraulic Gradient at Coastal Aquifers in Eastern Part of Jeju Island (2005)

Groundwater level changes in coastal aquifers occur due to oceanic tides, where the properties of oceanic tides can be applied to estimate hyadraulic parameters. Hydraulic parameters of coastal aquifers located in eastern part of Jeju island were estimated using the tidal response technique. Groundwater level data from a saltwater intrusion monitoring well system was used which showed tidal effects from 3 to 5 km. The hydraulic gradient was assessed by utilizing the filtering method from 71 consecutive hourly water-level observations. Calculated hydraulic diffusivity ranged from 2.94 to 4.36 . The hydraulic gradient of the coastal aquifer area was found to be ~, whereas the gradient of the area between wells Handong-1 and 2 was found to be ~, which is very low comparatively. Analysis of groundwater monitoring data showed that groundwater levels are periodically higher near coastal areas compared to that of inner land areas due to oceanic tide influences. When assessing groundwater flow direction in coastal aquifers it is important to consider tidal fluctuation.
36-channel, 120 Gigabit/s parallel optical interconnect (2004)

This study reviews preliminary experimental data on accelerated aging test of VCSEL and detector arrays bonded to either silicon or SiGe application specific integrated circuits (ASICs). When compared with top emitting VCSEL (unbonded), results show that the flip chip bonding technology is more robust, reliable, and environmentally sound. In addition, technological benefits of 2-D array technology in terms of superior reliability over linear array solutions when scaling to high channel count is asserted. Moreover, reliability issues for modules are considered as the VCSEL data rate exceed 10 Gbs.
Energy Efficient Transceiver in Wireless Network on Chip Architectures (2016)

The emergent wireless Network-on-Chip (WiNoC) design paradigm has been proposed as a viable solution for addressing the scalability issues affecting the on-chip communication system in future manycores architectures. Within this scenario, the energy contribution of the buffers (both of the routers and radio-hubs) and the transceivers of the radio-hubs, account for a significant fraction of the total communication energy budget. In this paper, we propose a novel energy management scheme aimed at improving the energy efficiency of a WiNoC architecture based on the selective disabling of the power hungry modules that are predicted being not used during the forthcoming clock cycles. The proposed scheme, applied on different WiNoC topologies with different configurations and under different traffic scenarios, has shown interesting energy saving without any impact on the performance metrics and with a negligible impact on silicon area.
Effective electrical conductivity of two-phase disordered composite media (1985)

Perturbation expansions of the effective electrical conductivity σe of any two-phase isotropic composite medium of arbitrary dimensionality d (where d=2,3) are derived. It is shown that certain Padé approximants of a particular series representation of σe yield known rigorous bounds on the conductivity of the composite. The relationships between the conductivities of certain models that are exactly realized by some of these bounds and the perturbation expansions are discussed. A new expression for the conductivity of a broad class of three-dimensional dispersions of inclusions is derived. The formula for σe, which depends upon, among other quantities, a certain three-point probability function of the composite medium, is shown to accurately predict σe of both periodic and random arrays of impenetrable spheres, for a wide range of phase conductivities and inclusion volume fractions.
Zebrafish ambra1a and ambra1b Knockdown Impairs Skeletal Muscle Development (2014)

The essential role of autophagy in muscle homeostasis has been clearly demonstrated by phenotype analysis of mice with muscle-specific inactivation of genes encoding autophagy-related proteins. Ambra1 is a key component of the Beclin 1 complex and, in zebrafish, it is encoded by two paralogous genes, ambra1a and ambra1b, both required for normal embryogenesis and larval development. In this study we focused on the function of Ambra1, a positive regulator of the autophagic process, during skeletal muscle development by means of morpholino (MO)-mediated knockdown and compared the phenotype of zebrafish Ambra1-depleted embryos with that of Ambra1gt/gt mouse embryos. Morphological analysis of zebrafish morphant embryos revealed that silencing of ambra1 impairs locomotor activity and muscle development, as well as myoD1 expression. Skeletal muscles in ATG-morphant embryos displayed severe histopathological changes and contained only small areas of organized myofibrils that were widely dispersed throughout the cell. Double knockdown of ambra1a and ambra1b resulted in a more severe phenotype whereas defects were much less evident in splice-morphants. The morphants phenotypes were effectively rescued by co-injection with human AMBRA1 mRNA. Together, these results indicate that ambra1a and ambra1b are required for the correct development and morphogenesis of skeletal muscle.
Electron spin relaxation in zinc-blende heterostructures (2000)

Spin relaxation in-plane anisotropy is predicted for heterostructures based on zinc-blende semiconductors. It is shown that it manifests itself especially clearly if the two contributions to the D'yakonov-Perel' spin relaxation mechanism (due to the bulk spin-orbit interaction term and the Rashba term) are comparable in efficiency. Concentration dependences of spin relaxation rates for a heterostructure grown along the [001] direction are plotted for different electron spin orientations.
Structure-sensitivity relationship of anthracycline antibiotics to C7-reduction by redox enzymes. (1991)

About 30 antitumor anthracycline antibiotics were tested for their susceptibilities to reductive deglycosidation at C-7 catalyzed by rat liver microsomal NADPH-cytochrome P-450 reductase, xanthine oxidase, cytochrome C reductase and DT-diaphorase. Enzymatic activities to reduce the C-7 position of anthracycline antibiotics were similar among the four redox enzymes although a few exceptions were observed with DT-diaphorase. Among therapeutic use of anthracyclines, aclacinomycin A (ACM-A, aclarubicin) and daunomycin (daunorubicin) were found to be highly sensitive to the redox enzymes tested while adriamycin (ADM, doxorubicin) and THP-ADM (pirarubicin) were resistant to enzymatic reductive deglycosidation. When glycosidic and hydroxylated analogs of ACM-A were compared it was found that anthracyclines with smaller glycoside residues were more sensitive to the redox enzymes and the presence of hydroxyl groups on the aglycone moiety decreased the reductive deglycosidation activities. Thus, the aglycone, aklavinone, was most rapidly reduced to 7-deoxyaklavinone. 1-Hydroxy-, 2-hydroxy-, 11-hydroxy- and 1,11-dihydroaclacinomycins A were more resistant to the redox enzymes that ACM-A. Especially, 2-hydroxyaclacinomycins were completely insensitive to the enzymatic reduction. THP-ADM, 4'-substituted analog of ADM, was more resistant to the redox enzymes than ADM itself. These results show that the presence of a hydroxyl group, its position on aglycone, the presence of 4'-substituent on aminosugar and its length in the anthracycline molecule play important roles on the C-7 reduction by the redox enzymes. Relationship between reductive deglycosidation susceptibilities and cell-growth inhibitory activities of anthracycline antibiotics are also discussed.
Hydrogenation of CO2 to Dimethyl Ether over Brønsted Acidic PdZn Catalysts (2018)

Eschewing the common trend toward use of&#13;\ncatalysts composed of Cu, it is reported that PdZn alloys are&#13;\nactive for CO2 hydrogenation to oxygenates. It is shown that&#13;\nenhanced CO2 conversion is achievable through the&#13;\nintroduction of Brønsted acid sites, which promote dehydration&#13;\nof methanol to dimethyl ether. We report that&#13;\ndeposition of PdZn alloy nanoparticles onto the solid acid&#13;\nZSM-5, via chemical vapor impregnation affords catalysts for&#13;\nthe direct hydrogenation of CO2 to DME. This catalyst shows&#13;\ndual functionality; catalyzing both CO2 hydrogenation to&#13;\nmethanol and its dehydration to dimethyl in a single catalyst&#13;\nbed, at temperatures of &gt;270 °C. A physically mixed bed&#13;\ncomprising 5% Pd 15% Zn/TiO2 and H-ZSM-5 shows a&#13;\ncomparably high performance, affording a dimethyl ether synthesis rate of 546 mmol kgcat&#13;\n−1 h−1 at a reaction temperature of 270&#13;\n°C.