gebhart/patrepeval huggingface dataset:
Abstract 13829: Index Event, Clinical Outcomes and Response to Vericiguat in the Victoria Trial (2020)

Introduction: The VICTORIA (Vericiguat Global Study in Subjects with HF with Reduced EF) trial included 5050 patients in 3 discrete subgroups reflecting their index worsening heart failure (HF) event: &lt;3 months after HF hospitalization (HFH) (n=3366), 3-6 months after HFH (n=871), and those requiring IV diuretic therapy without HFH within the prior 3 months (n=813). We evaluated clinical characteristics, outcomes and treatment response to vericiguat across these index event subgroups in VICTORIA. Methods: We compared primary composite (CV death and HFH) and secondary (all-cause death and HFH) outcomes across index event subgroups, both before and after adjusting for clinical covariates (HF duration, NYHA class, medical history, heart rate, HF medications and laboratory values including baseline NT-proBNP), as well as their response to vericiguat. Results: Baseline characteristics were balanced between treatment arms within each subgroup. Over a median follow up of 10.8 months, the absolute primary event rates were high in all subgroups (20.5 - 42.5 per 100 patient-years, Figure). Compared to the IV diuretic group highest relative risk was in HFH &lt;3 months (HR 1.69, 95% CI 1.46-1.95), followed by HFH 3-6 months (HR 1.26, 95% CI 1.06-1.50). After multivariable adjustment, this difference remained significant only in HFH &lt;3 months (adjusted HR [vs IV diuretic] 1.47, 95% CI 1.26-1.72). Vericiguat was associated with reduced risk of the primary outcome overall (HR 0.90, 95% CI 0.82-0.98) and in all 3 subgroups, with no evidence of treatment heterogeneity. Similar results were evident for the secondary composite outcome. Conclusions: Among patients with worsening chronic HF, those within a 3 month window of HFH had almost a 1.5 times risk of CV death or HFH compared to those requiring IV diuretics but not HFH , irrespective of age or clinical risk factors. Vericiguat added to standard therapy was associated with similar benefit across the spectrum of risk in worsening HF.
Neutron Transmission Imaging with a Portable D-T Neutron Generator (2021)

Fast-neutron transmission imaging provides complementary information to x-ray transmission imaging. While fast neutron imaging resolution is generally below x-ray imaging, 14-MeV neutrons have an advantage over portable x-ray systems. Neutrons have higher transmission through high-Z materials due to a more uniform attenuation as a function of material atomic number Z compared to X-rays, and can therefore image low-Z materials inside high-Z materials. As a result, portable neutron transmission imaging has many applications, including inspection of concrete and welds for corrosion in vehicles, bridges, and other infrastructure, measurement of material levels in containers, and inspection of suspicious packages. Fast-neutron imaging is also more practical for field use than thermal-neutron imaging due to the size and shielding requirements typical of thermal-imaging systems compared to the availability of small 14.1 MeV D-T neutron generators. However, there are limitations in portable fast-neutron imaging systems, including limited neutron output, limited light produced by neutron scintillators, and lower resolution due to neutron source spot size and 2-3 mm scintillator thickness. In addition, digital-panel dark-noise is roughly 100x higher than neutron scintillator light, and variations in noise across the panel and in time is comparable to the imaging signal. Here we discuss recent efforts in developing a portable fast-neutron radiography system, including an improved neutron scintillator, mitigation of panel noise, and new commercial portable D-T neutron generators. We also present MCNP efforts to model neutron imaging, including scintillator resolution and the effects of neutron scattering from the object and surrounding materials.
Long Term Performance of a Bi-Directional Neural Interface for Deep Brain Stimulation and Recording (2022)

<b>Background:</b> In prior reports, we described the design and initial performance of a fully implantable, bi-directional neural interface system for use in deep brain and other neurostimulation applications. Here we provide an update on the chronic, long-term neural sensing performance of the system using traditional 4-contact leads and extend those results to include directional 8-contact leads. <b>Methods:</b> Seven ovine subjects were implanted with deep brain stimulation (DBS) leads at different nodes within the Circuit of Papez: four with unilateral leads in the anterior nucleus of the thalamus and hippocampus; two with bilateral fornix leads, and one with bilateral hippocampal leads. The leads were connected to either an Activa PC+S<sup>®</sup> (Medtronic) or Percept PC<sup>°ledR</sup> (Medtronic) deep brain stimulation and recording device. Spontaneous local field potentials (LFPs), evoked potentials (EPs), LFP response to stimulation, and electrode impedances were monitored chronically for periods of up to five years in these subjects. <b>Results:</b> The morphology, amplitude, and latencies of chronic hippocampal EPs evoked by thalamic stimulation remained stable over the duration of the study. Similarly, LFPs showed consistent spectral peaks with expected variation in absolute magnitude dependent upon behavioral state and other factors, but no systematic degradation of signal quality over time. Electrode impedances remained within expected ranges with little variation following an initial stabilization period. Coupled neural activity between the two nodes within the Papez circuit could be observed in synchronized recordings up to 5 years post-implant. The magnitude of passive LFP power recorded from directional electrode segments was indicative of the contacts that produced the greatest stimulation-induced changes in LFP power within the Papez network. <b>Conclusion:</b> The implanted device performed as designed, providing the ability to chronically stimulate and record neural activity within this network for up to 5 years of follow-up.
IEEE Press Series on Sensors (2020)

Sensing phenomena and sensing technology is perhaps the most common thread that connects just about all areas of technology, as well as technology with medical and biological sciences.Until the year 2000, IEEE had no journal or transactions or a society or council devoted to the topic of sensors.It is thus no surprise that the IEEE Sensors Journal launched by the newly-minted IEEE Sensors Council in 2000 (with this Series Editor as founding Editor-in-Chief) turned out to be so successful, both in quantity (from 460 to 10,000 pages a year in the span 2001-2016) and quality (today one of the very top in the field).The very existence of the Journal, its owner, IEEE Sensors Council, and its flagship IEEE SENSORS Conference, have stimulated research efforts in the sensing field around the world.The same philosophy that made this happen is brought to bear with the book series.
A Resistor-Based Temperature Sensor With a 0.13 pJ $\cdot$ K2 Resolution FoM (2017)

This paper describes a high-resolution energy-efficient CMOS temperature sensor, intended for the temperature compensation of MEMS/quartz frequency references. The sensor is based on silicided poly-silicon thermistors, which are embedded in a Wien-bridge RC filter. When driven at a fixed frequency, the filter exhibits a temperature-dependent phase shift, which is digitized by an energy-efficient continuous-time phase-domain delta-sigma modulator. Implemented in a 0.18-μm CMOS technology, the sensor draws 87 μA from a 1.8 V supply and achieves a resolution of 410 μK <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> in a 5-ms conversion time. This translates into a state-of-the-art resolution figure-of-merit of 0.13 pJ · K <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . When packaged in ceramic, the sensor achieves an inaccuracy of 0.2 °C (3σ) from -40 °C to 85 °C after a singlepoint calibration and a correction for systematic nonlinearity. This can be reduced to ±0.03 °C (3σ) after a first-order fit. In addition, the sensor exhibits low 1/f noise and packaging shift.
TRILL Transparent Transport over MPLS (2016)

This document specifies how to interconnect multiple Transparent
Interconnection of Lots of links (TRILL) sites with an intervening
MPLS network using existing TRILL and VPLS standards. This draft
addresses two problems as follows: 1) Providing connection between
more than two TRILL sites that are separated by MPLS provider network.
2) Providing a single logical virtualized TRILL network for different
tenants that are separated by an MPLS provider network.
LARGE AREA PYROELECTRIC MOTION TRACKING SYSTEM (2005)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Shankar, D. B. Jones, R. G. Swagart, J. B. Burchett, B. D. Guenther, S. D. Feller, and D. J. Brady, "LARGE AREA PYROELECTRIC MOTION TRACKING SYSTEM," in Adaptive Optics: Analysis and Methods/Computational Optical Sensing and Imaging/Information Photonics/Signal Recovery and Synthesis Topical Meetings on CD-ROM, Technical Digest (Optica Publishing Group, 2005), paper CTuC6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Selective Activation of Trophoblast-specific PLAC1 in Breast Cancer by CCAAT/Enhancer-binding Protein β (C/EBPβ) Isoform 2 (2009)

The trophoblast-specific gene PLAC1 (placenta-specific 1) is ectopically expressed in a wide range of human malignancies, most frequently in breast cancer, and is essentially involved in cancer cell proliferation, migration, and invasion. Here we show that basal activity of the PLAC1 promoter is selectively controlled by ubiquitous transcription factor SP1 and isoform 2 of CCAAT/enhancer-binding protein beta that we found to be selectively expressed in placental tissue and cancer cells. Binding of both factors to their respective elements within the PLAC1 promoter was essential to attain full promoter activity. Estrogen receptor alpha (ERalpha) signaling further augmented transcription and translation of PLAC1 and most likely accounts for the positive correlation between PLAC1 expression levels and the ERalpha status we observed in primary breast cancer specimens. DNA affinity precipitation and chromatin immunoprecipitation assays revealed that transactivation of the PLAC1 promoter by ligand-activated ERalpha is based on a nonclassical pathway independent of estrogen-response elements, by tethering of ERalpha to DNA-bound CCAAT/enhancer-binding protein beta-2, and SP1. Our findings provide first insight into a novel and hitherto unknown regulatory mechanism governing selective activation of trophoblast-specific gene expression in breast cancer.
<title>Sequential injection separation and sensing</title> (1999)

Automated microfluidic analysis has historically been carried out by flow injection analysis techniques. Sequential injection analysis represents a more versatile method for automated fluid handling. We have explored the use of sequential injection analysis for performing microcolumn separations. These separations can be used as part of a microanalytical procedure, or for sample preparation. In addition, with detection of retained species on the microcolumn, sequential injection separation represents a technique for sensing. Recently, it has been demonstrated that sequential injection separation can be carried out with renewable separation columns--the beads with interactive surfaces can be delivered to the microcolumn, used for processing the sample, and discarded after each measurement. Delivery of new beads for each measurement provides a method for renewable surface separation and renewable surface sensing. Applications in environmental analysis and bioanalytical chemistry will be presented.
pyKNEEr: An image analysis workflow for open and reproducible research on femoral knee cartilage - Validation data (2019)

Image data used in the paper introducing pyKNEEr. Explanations about these data are in the GitHub repository Changes in version 0.2.0: - Added inHouse images - Segmented images casted to int16 for smaller file size
DDS and Me (2004)

With the success of the human genome project, the focus of life science research has shifted to the functional and structural analyses of proteins, such as proteomics and structural genomics. These analyses of proteins including newly identified proteins are expected to contribute to the identification of therapeutically applicable proteins for various diseases. Thus, pharmaco-proteomic-based drug discovery and development for protein therapies, including gene therapy, cell therapy, and vaccine therapy, is attracting current attention. However, there is clinical difficulty in using almost all bioactive proteins, because of their very low stability and pleiotropic actions in vivo. To promote pharmaco-proteomic-based drug discovery and development, we have attempted to develop drug delivery systems (DDSs), such as the protein-drug innovation system and the optimal cell therapeutic system. In this review, we introduce our original DDSs.
Supporting Figures S5-S8 from Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer (2023)

&lt;p&gt;S5: UT-155 prevents nuclear localization of AR and AR v567es. S6: UT-155 binds to AR AF-1 domain. S7: Results from microarray with SARDs.S8: UT-155 inhibits transactivation of AD1 and D567es AR transactivation. Metabolism properties of SARDs.&lt;/p&gt;
Molecular Dynamic Simulation of Evaporative Heat Transfer on Graphene Coated Silicon Substrate for Electronics Cooling (2019)

Traditional heat dissipation methods based on single phase air or liquid cooling are reaching their limits for keeping the functional unit at a sufficiently low temperature with an ultra-high heat flux $( \gt 1\mathrm {k}\mathrm {W}/\mathrm {c}\mathrm {m}^{2})^{1-2}$. Twophase cooling such as thin film evaporation, owing to the large amount of latent heat in the phase change process, can effectively remove large amounts of heat while maintaining a small temperature difference across the heat transport system. As the evaporating liquid becomes sufficient thin, the surface characteristics such as interfacial thermal resistance become important parameters affecting the heat and mass transport during thin-film evaporation. This resistance is induced by the acoustic mismatch between the solid and liquid molecules, which impedes for heat propagating across the interface 3–4. Besides, based on the fundamental theory behind interfacial thermal resistance, the heat exchange across the solid-liquid interface is a strong function of the affinity between the two phases, i.e., the surface wettability. In general, it is expected that interfacial thermal resistance is positively related to the contact angle of the working fluid on the solid substrate. However, it remains unclear if the surface wettability has a direct impact on evaporative transport behavior from a thin liquid film. More importantly, we still lack a general description of the change in interfacial resistance with surface wettability and how such resistance can affect the thin-film evaporative transport. Understanding the relationship between interfacial thermal resistance, surface wettability, and evaporation behavior is important for evaluating the evaporative transport rate on different surfaces and designing rational nanocoatings to enhance evaporative heat transfer.
Fab-Nanolipoprotein Conjugate Causes Vitreous Opacity and Cataracts Following a Single Intravitreal Administration in New Zealand White Rabbits (2020)

One strategy employed to prolong the ocular half-life of large molecule therapeutics is via covalent attachment to a carrier, resulting in an increase in size thereby slowing their clearance from the eye. Rabbit antigen-binding fragment conjugated to nanolipoprotein (RabFab-NLP) is a novel conjugate intended to prolong ocular half-life through an increase in hydrodynamic radius compared to Fab alone (∼12 vs ∼3 nm). Nanolipoproteins are mimetics of endogenous high-density lipoproteins and consist of lipids and apolipoproteins (ApoE422k), both biologically derived materials. The objective of this study was to evaluate the ocular toxicity and toxicokinetics of RabFab-NLP after a single intravitreal administration in New Zealand White rabbits. Serum toxicokinetic data suggested a significant increase in ocular residence time of RabFab-NLP compared to RabFab alone. Ophthalmic examinations showed that RabFab-NLP caused vitreous and lens opacities as early as day 3 and day 8 postdose, respectively, which persisted for the entire study duration to day 30. The RabFab-NLP-related microscopic findings were present in the lens, vitreous cavity, and/or optic nerve head. Based on the observed ocular toxicity, a single intravitreal dose of 1.3 mg/eye RabFab-NLP was not tolerated and caused vitreous opacity and cataracts in rabbit eyes.
Targeting vascular (endothelial) dysfunction (2016)

This article is part of a themed section on Redox Biology and Oxidative Stress in Health and Disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.12/issuetoc.
Altering electrical connections in the nervous system of the pteropod mollusc Clione limacina by neuronal injections of gap junction mRNA (2002)

Neurons can communicate with each other either via exchange of specific molecules at synapses or by direct electrical connections between the cytoplasm of either cell [for review see Bruzzone et al. (1996) Eur. J. Biochem., 238, 1-27]. Although electrical connections are abundant in many nervous systems, little is known about the mechanisms which govern the specificity of their formation. Recent cloning of the innexins--gap junction proteins responsible for electrical coupling in invertebrates (Phelan et al. (1998) Trends Genet., 14, 348-349], has made it possible to study the molecular mechanisms of patterning of the electrical connections between individual neurons in model systems. Here we demonstrate that intracellular injection of mRNA encoding the molluscan innexin Panx1 (Panchin et al. 2000 Curr. Biol., 10, R473-R474) drastically alters the specificity of electrical coupling between identified neurons of the pteropod mollusc Clione limacina.
Novel vaccination strategies (2005)

Vaccination is one of the most significant public health interventions ever made, sparing millions of people from infectious diseases. It has been calculated that use of currently available vaccines saves more than eight million lives annually, which corresponds to one person saved every five seconds. These remarkable results have been achieved in 200 years of vaccination history, which are largely based on two basic, simple technologies: the inactivation of toxins and pathogens with formaldehyde treatment (first performed by Glenny and Hopkins in 1923 and Ramon in 1924) [1–3], and the stable attenuation of pathogens by serial passage in vitro. From 1920 to 1980, these now “easy technologies” were applied to develop vaccines that have been used worldwide to control or even eradicate many infectious diseases. One of the most brilliant successes of vaccination is the eradication of smallpox virus in 1977. It has been estimated that to date, smallpox eradication has spared the global community of some 350 million new smallpox victims and about 40 million deaths from the disease. The annual savings as a result of vaccination being stopped and hospitals being able to be converted to other uses is estimated to be in excess of US$ 2000 million each year [4]. Vaccination has also resulted in the elimination of poliovirus from the Americas in 1994, Western Pacific in 2000 and Europe in June 2002. The goal of the WHO Global Polio Eradication Initiative is to interrupt transmission of wild poliovirus by end-2004 leading to global certification by 2008. Overall, since the Initiative was launched in 1988, the number of cases has fallen by over 99%, from an estimated 350,000 cases to the 89 cases reported in the first three months of 2004. In the same period, the number of polio-infected countries was reduced from 125 to 6 [5]. Moreover, the incidence of seven other frightening diseases (diphtheria, measles, rubella, mumps, pertussis, Haemophilus influenzae type b – Hib –, and tetanus) has fallen by more than 98% in those states where the related vaccines have been introduced (see Tab. 1). Novel vaccination strategies
Experimental investigation on 15 GHz band integrated front-end module including antenna and filter for 5G mobile communications systems (2017)

This paper proposes an integrated module configuration including a slot antenna and a substrate integrated waveguide (SIW) filter for a vehicular transceiver. It is very important that the vehicular transceiver provides lower profile and lighter weight because of installing for an automobile roof. The proposed configuration only employs one print board where one side has the slot antenna and the opposite side has the SIW filter. In order to investigate, a 15 GHz band proposed module is fabricated. Experimental results confirm that the fabricated module offers the frequency characteristics of gain attained by the proposed configuration. This investigation leads to extremely lower profile and lighter weight of vehicular transceiver.