gebhart/patrepeval huggingface dataset:
Heptamethoxyflavone, a citrus flavonoid, suppresses inflammatory osteoclastogenesis and alveolar bone resorption (2014)

We examined the effects of heptamethoxyflavone (HMF), a citrus flavonoid on inflammatory bone resorption. HMF suppressed the osteoclast formation and PGE2 production induced by IL-1. In mouse calvarial organ cultures, HMF attenuated the bone resorption elicited by LPS. HMF suppressed bone resorption in the mandibular alveolar bone. HMF may protect against inflammatory bone loss such as periodontal disease.
Cancer-Associated Fibroblasts: Building Blocks of the Tumor Stroma (2021)

Cancer-Associated Fibroblasts (CAFs) are one of the most abundant cells in the stromal region of most solid tumors. CAFs are considered as the main source for the production of extracellular matrix in the tumor stroma. Differentiation and multiplication of CAFs is directly correlated with cancer aggressiveness and relapse chances as obviously reported in case of the highly desmoplastic pancreatic ductal adenocarcinoma. The Extracellular Matrix (ECM) constitutes the major part of the tumor stroma, and is defined as the non-cellular, intercellular component of the tumor stroma. ECM carries key physiological functions within tissues such as cellular adhesion, cell–cell crosstalk, and cell differentiation. Interestingly, in combination with gemcitabine, calcipotriol, a vitamin D3 analogue has been shown to reprogram the tumor stroma and promote gemcitabine intratumoral accumulation, lowered tumor volume, and reduced mortality in pancreatic cancer murine model. Interestingly, metformin, an anti-diabetic drug, and arsenic trioxide were found to restore cancer cells sensitivity to tamoxifen in breast cancer cells.
Doping Concentration Optimization for Ultra-Low-Loss 4H-SiC Floating Junction Schottky Barrier Diode (Super-SBD) (2009)

Previous simulation works and experiments on the loss of 4H-SiC floating junction Schottky barrier diodes (Super-SBDs) show that the loss is related to the doping concentration in the drift region and the pattern of the floating layer. The effect of the doping concentration for lowering the loss is characterized the breakdown voltage (Vbd) and the on-state resistances (RonS) of the Super-SBDs based on Baliga’s figure of Merit (BFOM). Experimental devices with two doping concentrations in the drift region are fabricated to investigate the static characteristics: Vbd and RonS. The Vbd of the Super-SBDs is close to the simulation result, near 3000 V. However the tendency of the Vbd by the doping concentration is not similar to the simulation result. And the RonS are about 3.22 mcm2 which is higher than that of simulation result. The doping concentration optimized in this study does not show significant lowering loss and the design of the floating layer in the termination region affect the low-loss static characteristics of the Super-SBD. In addition, adopting PiN structure with floating layer (Super-PiN) affects the low-loss dynamic characteristics, optimizing the doping concentration in the drift region. We conclude that the fabricated Super-SBDs with the floating layer in the termination region, the drift region with a doping concentration of 1.01016 cm-3 and mesa-shaped termination structure, have excellent Vbd of 2990 V which is almost same as that of simulation result and RonS of 3.22 mcm2.
An assessment of SMS fraud in Pakistan (2019)

SMS fraud has become a growing concern for those working toward financial inclusion, however, it is often unclear how widespread such threats are in practice. This multi-method study investigates SMS fraud in Pakistan through identification and categorization of fraudulent messages as well as the impact on those who receive such messages. We collect fraudulent SMS messages by various means, including byway of a custom-built Android smartphone application. To complement this, we interview people exposed to SMS fraud and representatives of mobile network operators. Based on our analysis, lottery type fraud schemes dominate SMS fraud in Pakistan, and these schemes have the greatest impact on vulnerable low-income, rural populations. We offer a simple heuristic for fraud detection that has a high accuracy rate and is adaptable to evolving fraud schemes, and conclude with a recommendation for a fraud mitigation strategy to target fraudster call back numbers.
The Microbial Rosetta Stone Database: A compilation of global and emerging infectious microorganisms and bioterrorist threat agents (2005)

The Microbial Rosetta Stone is available at http://www.microbialrosettastone.com/. The database provides public access to up-to-date taxonomic classifications of organisms that cause human diseases, improves the consistency of nomenclature in disease reporting, and provides useful links between different public genomic and public health databases.
McElroy field: Development of a dolomite reservoir, Permian Basin of west Texas (1987)

Delivering adequate care to older people requires an increasing number of physicians competent in the treatment of this expanding subpopulation. Attitudes toward older adults are important as predictors of the quality of care of older people and of medical trainee likelihood to enter the geriatrics field. This study assessed the attitudes of 404 US medical students (MS) from the start of medical school to graduation using the University of California, Los Angeles (UCLA) Geriatrics Attitude Scale. It is the first study to utilize a longitudinal design to assess attitudes among students in a medical school with a longitudinal geriatrics clinical experience in the first two years and a required geriatrics clerkship in the third year. Participants' attitude scores toward older people were found to significantly decrease from 3.9 during the first two years to 3.7 during the final two. Significant differences existed between MS1 and MS3, MS1 and MS4, MS2 and MS3, and MS2 and MS4. Women and older students held significantly more positive attitudes than men and younger students. These results show that planned clinical exposures to older adults may not be sufficient to halt the decline in attitudes in medical school. A comprehensive empathy-building intervention embedded in the curriculum may better prevent this decline.
JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias (2018)

Activating JAK2 point mutations are implicated in the pathogenesis of myeloid and lymphoid malignancies, including high-risk B-cell acute lymphoblastic leukemia (B-ALL). In preclinical studies, treatment of JAK2 mutant leukemias with type I JAK2 inhibitors (e.g., Food and Drug Administration [FDA]-approved ruxolitinib) provided limited single-agent responses, possibly due to paradoxical JAK2<sup>Y1007/1008</sup> hyperphosphorylation induced by these agents. To determine the importance of mutant JAK2 in B-ALL initiation and maintenance, we developed unique genetically engineered mouse models of B-ALL driven by overexpressed Crlf2 and mutant Jak2, recapitulating the genetic aberrations found in human B-ALL. While expression of mutant Jak2 was necessary for leukemia induction, neither its continued expression nor enzymatic activity was required to maintain leukemia survival and rapid proliferation. CRLF2/JAK2 mutant B-ALLs with sustained depletion or pharmacological inhibition of JAK2 exhibited enhanced expression of c-Myc and prominent up-regulation of c-Myc target genes. Combined indirect targeting of c-Myc using the BET bromodomain inhibitor JQ1 and direct targeting of JAK2 with ruxolitinib potently killed JAK2 mutant B-ALLs.
Basics – Screw Elements (2019)

No AccessCo-Rotating Twin-Screw Extruders: FundamentalsNov 2019Basics – Screw ElementsKlemens KohlgrüberKlemens KohlgrüberSearch for more papers by this authorhttps://doi.org/10.3139/9781569907481.002SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2019Pages: 101-188Print ISBN: 978-1-56990-747-4eISBN: 978-1-56990-748-1 Copyright & PermissionsCopyright by Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
DHCPv6 Options for Configuration of Softwire Address and Port-Mapped Clients (2015)

This document specifies DHCPv6 options, termed Softwire46 options, for the provisioning of Softwire46 Customer Edge (CE) devices.Softwire46 is a collective term used to refer to architectures based on the notion of IPv4 Address plus Port (A+P) for providing IPv4 connectivity across an IPv6 network.
Development of multi-stack dielectric wafer bonding (2016)

We investigate multi-stack dielectric wafer bonding through two integration schemes, which provide different paths to realize vertical integration of multiple device layers. Key process steps are evaluated and optimized to enable void-less bonds at different bonding layers. Meanwhile, issues related to the wafer edge are discovered during the backside processing and the impact is analyzed. Finally, N=4 stacks are successfully demonstrated with high quality interfaces formed by dielectric bonding.
Photocatalytic syngas production using conjugated organic polymers (2021)

A range of linear conjugated polymers is reported that promote simultaneous photocatalytic CO<sub>2</sub> reduction and proton reduction with a sacrificial hole-scavenger.
Quantitative characterization of higher-order mode converters in weakly multimoded fibers (2003)

We present a rigorous analysis methodology of fundamental to higher order mode converters in step index few mode optical fibers. We demonstrate experimental conversion from a fundamental LP01 mode to the higher order LP11 mode utilizing a multiple mechanical bend mode converter. We perform a quantitative analysis of the measured light intensity, and demonstrate a modal decomposition algorithm to characterize the modal content excited in the fiber. Theoretical modelling of the current mode converter is then performed and compared with experimental findings.
Additively manufactured ultra-high vacuum chamber for portable quantum technologies (2021)

Additive manufacturing is having a dramatic impact on research and industry across multiple sectors, but the production of additively manufactured systems for ultra-high vacuum applications has so far proved elusive and widely been considered impossible. We demonstrate the first additively manufactured vacuum chamber operating at a pressure below 10−10 mbar, measured via an ion pump current reading, and show that the corresponding upper limit on the total gas output of the additively manufactured material is 3.6 × 10−13 mbar l/(s mm2). The chamber is produced from AlSi10Mg by laser powder bed fusion. Detailed surface analysis reveals that an oxidised, Mg-rich surface layer forms on the additively manufactured material and plays a key role in enabling vacuum compatibility. Our results not only enable lightweight, compact versions of existing systems, but also facilitate rapid prototyping and unlock hitherto inaccessible options in experimental science by removing the constraints that traditional manufacturing considerations impose on component design. This is particularly relevant to the burgeoning field of portable quantum sensors — a point that we illustrate by using the chamber to create a magneto-optical trap for cold 85Rb atoms — and will impact significantly on all application areas of high and ultra-high vacuum.
The Greening of Balboa Park: A Holistic, Sustainable and Replicable Model (2010)

Developed for the 1915 Panama Exposition, Balboa Park now houses more than two dozen major museums, performing arts organizations, gardens, and the San Diego Zoo. Located on over 1200 acres of land with over a million square feet of property, Balboa Park is one of the nation’s largest urban cultural centers, attracting more than 6.5 million visitors annually from around the world. Through recent collaborative efforts, Balboa Park is poised to become a national model for cultural institutions and urban parks to achieve environmental sustainability. In 2008 the Balboa Park Cultural Partnership established a Park-wide sustainability program that includes 26 cultural institutions, the City of San Diego, San Diego Gas & Electric, and many other community stakeholders. Designed to be a replicable model, the Partnership’s goals are the creation and alignment of sustainable business practices; the identification of, and communication with, key internal and external stakeholders; and the education of visitors, employees, stakeholders, and the public. All sustainability initiatives and results are benchmarked, measured and quantified—a vital component for measuring its carbon footprint and aligning with the state’s plan for energy efficiency. The Balboa Park Cultural Partnership (BPCP) has become the first network of cultural institutions in the country to benchmark the energy performance of its buildings using the Environmental Protection Agency’s (EPA) ENERGY STAR® Portfolio Manager. This paper outlines BPCP’s approach to energy efficiency, resource management, land use and building retrofits, using the following methodology 1 : • How the program aligns with the Partnership’s mission and vision • How the initial key stakeholders (internal/external) were identified • The levels and types of stakeholder engagement • The program’s core areas of focus • How actions are quantified and prioritized, and • A review of results, relevant case studies, and future steps.
A simple direct procedure for the regiospecific preparation of chloro aromatic compounds (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA simple direct procedure for the regiospecific preparation of chloro aromatic compoundsElliott Bay, Peter E. Timony, and Andrea Leone-BayCite this: J. Org. Chem. 1988, 53, 12, 2858–2859Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/jo00247a042https://doi.org/10.1021/jo00247a042research-articleACS PublicationsRequest reuse permissionsArticle Views897Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Far-Zone Focusing Lenses Designed by Complex Coordinate Transformations (2014)

In this letter, a transformation optics approach involving complex coordinates is presented for designing far-zone focusing lenses fed by a single radiating electromagnetic source. In contrast to conventional coordinate transformation (CT) methods that tailor only the real parts of the material parameters, a spatial amplitude tapering function containing either gain or loss is introduced within the lens, which provides an extra degree of freedom in controlling both the amplitude and phase distributions at the aperture of the lens, resulting in a controllable far-field radiation pattern. The concept is validated by full-wave lens simulations with parametric studies carried out to investigate the impact of both the geometrical and material properties of the lens on the far-field patterns. It is then demonstrated that the lens designs can be further optimized to control the sidelobe levels (peak as well as minor lobes) while maintaining a relatively high gain. Finally, it is shown that the lens exhibits a far-field radiation pattern comparable to that of a linear array with uniform element spacing, but is unidirectional rather than bidirectional. By providing a means to control both the amplitude and phase distribution across the lens aperture, the proposed complex CT design approach provides a pathway to constructing directive emitting devices with radiation properties similar to conventional antenna arrays but with only a single feeding source.
ChemInform Abstract: Synthesis Strategies for Preparing Useful Small Pore Zeolites and Zeotypes for Gas Separations and Catalysis (2014)

Abstract Review: 113 refs.
High-temperature Characterization of a 1200 V Power Module with 36 mm2 of SiC VJFET Area (2012)

This is the first high-temperature static and dynamic characterization of a half-bridge power module using 1200 V, 45 mΩ depletion-mode vertical JFETs. With only 36 mm2 of JFET area, the peak pulsed current is measured to be nearly 500 A at room temperature (transistors not saturated), decreasing to 230 A at 250 °C (transistors saturated). Total switching losses are less than 3.2 mJ from 25 °C to 250 °C and show negligible dependence on junction temperature. The achievement of this level of performance with such a small SiC transistor area is important, since die area directly impacts achievable module footprint (system-level power density and cost), device capacitance (switching losses), and semiconductor cost.
Electroless Deposition of Disordered RuO2 Nanoskins: An Example from the Fourth Quadrant of Electronic Materials (2017)

Our team at the Naval Research Laboratory has demonstrated that an ultrathin film of nanoscale, disordered ruthenium dioxide, designated RuO 2 nanoskin, can be deposited from commercially available precursors onto metal, ceramic, semiconductor, polymer, and salt substrates using scalable, atom-efficient, low-temperature, liquid-phase, self-limiting electroless deposition. The electrical conductivity of the resulting nanoskins can be tuned over three orders of magnitude by calcining without ripening the particles comprising the film. On the basis of optical, electrical, structural, thermal, microscopic, mechanical, electrochemical, and chemical state measurements, we categorize this disordered, nanoscale oxide as a member of a rare quadrant of electronic materials: one that exhibits a high concentration of electronic carriers (n) of low mobility (m). The remarkable physicochemical properties of RuO 2 nanoskins point to the importance of expressing functional materials in disordered, forms.
Hypothalamic Hormones (1997)

Alkmeon, a 6th century B.C. physiologist and philosopher, introduced the brain as the center of human thinking, organizer of the senses, and coordinator for survival. However, the need for a visible connection between the brain and the rest of the body to explain a rapid and effective way of communication that would maintain homeostasis led Aristotle to the erroneous conclusion that the heart was the central coordinating organ and blood the means of information transmission. In contemporary medicine, the two ancient concepts are integrated in the exciting field of neuroendocrinology. The traditional distinctions between neural (brain) and hormonal (blood) control have become blurred. Endocrine secretions are influenced directly or indirectly by the central nervous system (CNS), and many hormones influence brain function. The hypothalamic—pituitary unit is the mainstay of this nonstop, interactive, and highly efficient between the two systems. Its function is mediated by hypothalamic-releasing or hypothalamic-inhibiting hormones, including gonadotropin-releasing hormone (GnRH), thyrotropin-releasing hormone (TRH), growth hormone-releasing hormone (GHRH), somatostatin (SRIF), corticotropin-releasing hormone (CRH), and the neurotransmitter dopamine.
Particle Simulations of Sheath Dynamics in Low-Pressure Capacitively Coupled Argon Plasma Discharges (2011)

A numerical study of low-pressure capacitively coupled plasma (CCP) discharges in Ar has been performed including the transport of ions in a sheath onto a substrate. We employ a two-dimensional axisymmetric particle-in-cell with a Monte Carlo collision (PIC-MCC) method for an asymmetric capacitive discharge with an external electrical circuit containing a blocking capacitor and an rf power supply. The PIC-MCC results show that for the gas pressure (5–100 mTorr), rf voltage (50–500 V), and frequency (6.78–40.68 MHz) ranges examined for a single-frequency CCP, the peak plasma density increases linearly with gas pressure, rf voltage, and frequency squared. With a decrease in pressure or increases in plasma density and sheath potential, the sheath becomes less collisional and thus significant peaks at high energies of ion energy distributions appear and narrow ion angular distributions are obtained. The tendency is in a reasonable agreement with experimental results.
Distance-Based Interpolation and Extrapolation Methods for RSS-Based Localization With Indoor Wireless Signals (2015)

Wireless local area network (WLAN)-based fingerprinting using received signal strength (RSS) has been considered to be one solution for indoor positioning. However, one widely recognized problem in fingerprinting is the collection and maintenance of a proper fingerprint database. In this paper, we consider having an incomplete fingerprint database with realistic coverage gaps, and we study the performance of several interpolation and extrapolation methods for recovering the missing fingerprint data. For this purpose, we have collected an extensive set of data at frequency bands of 2.4 and 5 GHz from one university building with four floors. The accuracy of the interpolation and extrapolation methods is studied by artificially removing fingerprints from the database using a randomized procedure and by comparing the estimated fingerprints with the original fingerprints. The average RSS estimation error of different interpolation and extrapolation methods is shown for various percentages of missing fingerprints. In addition, a cumulative RSS error distribution is studied to reveal the dispersion of the error statistics, which affect the user positioning accuracy. Here, the user positioning accuracy is defined in terms of horizontal positioning error and floor detection probability. The user positioning accuracy is also compared in four cases, namely when using the original fingerprints, the partial fingerprints, the interpolated fingerprints, and the interpolated and extrapolated fingerprints. It is shown that both the horizontal positioning accuracy and the floor detection probability can be improved with proper interpolation and extrapolation methods. However, it is also illustrated that the best positioning performance is not necessarily achieved with the best average interpolation and extrapolation accuracy, but it is important to avoid certain types of errors in interpolation and extrapolation.
Highly hydrophobic polyfluorinated azo dyes grafted on surfaces (2011)

Artificial hydrophobic surfaces have a great potential in a wide range of industrial applications owing to their self-cleaning, anti-fogging and anti-biofouling properties. A family of polyfluorinated reactive azo dyes has been prepared and some of them easily modified and grafted on cotton fabric and glass surfaces obtaining new coloured hydrophobic materials.