gebhart/patrepeval huggingface dataset:
MRI-guided fluorescence tomography of the breast: a phantom study (2009)

Tissue phantoms simulating the human breast were used to demonstrate the imaging capabilities of an MRI-coupled fluorescence molecular tomography (FMT) imaging system. Specifically, phantoms with low tumor-to-normal drug contrast and complex internal structure were imaged with the MR-coupled FMT system. Images of indocyanine green (ICG) fluorescence yield were recovered using a diffusion model-based approach capable of estimating the distribution of fluorescence activity in a tissue volume from tissue-boundary measurements of transmitted light. Tissue structural information, which can be determined from standard T1 and T2 MR images, was used to guide the recovery of fluorescence activity. The study revealed that this spatial guidance is critical for recovering images of fluorescence yield in tissue with low tumor-to-normal drug contrast.
Effects of Frequency, Percolation, and Axisymmetric Microstructure on the Electrical Response of Hot‐Pressed Alumina–Silicon Carbide Whisker Composites (2010)

The electrical and dielectric properties of hot‐pressed composites containing alumina and silicon carbide (SiC) whiskers were characterized over a wide frequency range (0.1 Hz–1.8 GHz). The results were correlated to the average distances between SiC inclusions which were measured by stereology as a function of orientation and composition. Percolation of the whiskers caused a drastic increase in the dc conductivity and the prominence of a dc‐conductivity tail associated with a high‐frequency Maxwell–Wagner interfacial polarization. In percolated samples, the tail obscured the dielectric loss peak and there was evidence for the fluctuation‐induced tunneling mechanism of conduction. In nonpercolated samples, the loss peak was observed and the complex permittivity data were fit with a modified Maxwell–Wagner equation to account for a distribution of relaxation times. The frequency–dispersion magnitudes, fitting exponents, and central relaxation times were orientation‐dependent. Also, a damped resonance was observed between 1.4 and 1.7 GHz. The influence of the results on the microwave‐heating application is discussed.
Internet of NanoThings: Concepts and Applications (2018)

This chapter focuses on Internet of Things from the nanoscale point of view. The chapter starts with section 1 which provides an introduction of nanothings and nanotechnologies. The nanoscale communication paradigms and the different approaches are discussed for nanodevices development. Nanodevice characteristics are discussed and the architecture of wireless nanodevices are outlined. Section 2 describes Internet of NanoThing(IoNT), its network architecture, and the challenges of nanoscale communication which is essential for enabling IoNT. Section 3 gives some practical applications of IoNT. The internet of Bio-NanoThing (IoBNT) and relevant biomedical applications are discussed. Other Applications such as military, industrial, and environmental applications are also outlined.
Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers (2009)

There was no single anti-HIV-1 antibody specificity that was a clear correlate of immunity in controllers. Rather, for most antibody types, controllers had the same or lower levels of nAbs than viremic individuals, with the possible exception of ADCC antibodies.
Experimental Investigation of Total Pressure Loss Development in a Highly Loaded Low Pressure Turbine Cascade (2017)

Improvements in turbine design methods have resulted in the development of blade profiles with both high lift and good Reynolds lapse characteristics. An increase in aerodynamic loading of blades in the low pressure turbine section of aircraft gas turbine engines has the potential to reduce engine weight or increase power extraction. Increased blade loading means larger pressure gradients and increased secondary losses near the endwall. Prior work has emphasized the importance of reducing these losses if highly loaded blades are to be utilized. The present study analyzes the secondary flow field of the front-loaded low-pressure turbine blade designated L2F with and without blade profile contouring at the junction of the blade and endwall. The current work explores the loss production mechanisms inside the low pressure turbine cascade. Stereoscopic particle image velocimetry data and total pressure loss data are used to describe the secondary flow field. The flow is analyzed in terms of total pressure loss, vorticity, Q-Criterion, turbulent kinetic energy and turbulence production. The flow description is then expanded upon using an Implicit Large Eddy Simulation of the flow field. The RANS momentum equations contain terms with pressure derivatives. With some manipulation these equations can be rearranged to form an equation for the change in total pressure along a streamline as a function of velocity only. After simplifying for the flow field in question the equation can be interpreted as the total pressure transport along a streamline. A comparison of the total pressure transport calculated from the velocity components and the total pressure loss is presented and discussed. Peak values of total pressure transport overlap peak values of total pressure loss through and downstream of the passage suggesting that total pressure transport is a useful tool for localizing and predicting loss origins and loss development using velocity data which can be obtained non-intrusively.
Author response: Cytotoxic T-cells mediate exercise-induced reductions in tumor growth (2020)

Exercise affects almost all tissues in the body, and scientists have found that being physically active can reduce the risk of several types of cancer as well as improving outcomes for cancer patients. However, it is still unknown how exercise exerts its protective effects. One of the hallmarks of cancer is the ability of cancer cells to evade detection by the immune system, which can in some cases stop the body from eliminating tumor cells. Rundqvist et al. used mice to investigate how exercise helps the immune system act against tumor progression. They found that when mice exercised, tumor growth was reduced, and this decrease in growth depended on the levels of a specific type of immune cell, the CD8+ T cell, circulating in the blood. Additionally, Rundqvist et al. found that CD8+ T cells were made more effective by molecules that muscles released into the blood during exercise. Isolating immune cells after intense exercise showed that these super-effective CD8+ T cells alter how they use molecules for energy production after exertion. Next, immune cells from mice that had exercised frequently were transferred into mice that had not exercised, where they were more effective against tumor cells than the immune cells from untrained mice. These results demonstrate that CD8+ T cells are altered by exercise to improve their effectiveness against tumors. The ability of T cells to identify and eliminate cancer cells is essential to avoid tumor growth, and is one of the foundations of current immune therapy treatments. Exercise could improve the outcome of these treatments by increasing the activation of the immune system, making tumor-fighting cells more effective.
Storage, retrieval, and communication of body sensor network data (2008)

Recently, Body Sensor Networks (BSNs) are being deployed for monitoring and managing medical conditions as well as human performance in sports. These BSNs include various sensors such as accelerometers, gyroscopes, EMG (Electromyogram), EKG (Electro-cardiograms), and other sensors depending on the needs of the medical conditions. Data from these sensors are typically Time Series data and the data from multiple sensors form multiple, multidimensional time series data. Analyzing data from such multiple medical sensors pose several challenges: different sensors have different characteristics, different people generate different patterns through these sensors, and even for the same person the data can vary widely depending on time and environment.This tutorial describes the technologies that go behind BSNs - both in terms of the hardware infrastructure as well as the basic software. First, we outline the BSN hardware features and the related requirements. We then discuss the energy and communication choices for BSNs. Next, we discuss approaches for classification, data mining, visualization, and securing these data. We also show several demonstrations of body sensor networks as well as the software that aid in analyzing the data.
Emergence of obsessive--compulsive symptoms and tics during clozapine withdrawal. (1998)

Treatment with clozapine may be associated with the appearance of obsessive-compulsive (OC) symptoms in up to 10% of schizophrenic patients. We present the first report of the emergence of de novo OC symptoms during clozapine withdrawal in two schizophrenic patients, associated in one with Tourette's syndrome-like tics. Resumption of clozapine led to the complete disappearance of the OC symptoms and a substantial alleviation of the tics. It is suggested that an imbalance between the dopamine and serotonin systems may account for this complication.
Selective Iterative Etching of Fused Silica with Gaseous Hydrofluoric Acid (2010)

Femtosecond laser irradiation followed by chemical etching (FLICE) with hydrofluoric acid (HF) is an emerging technique for the fabrication of directly buried, three-dimensional microfluidic channels. With liquid HF, the etching process is diffusion-limited and is self-terminating, leading to maximum microchannel lengths of ≈1.5 mm. A strategy to overcome this limitation would be to perform iterative etching, periodically removing the exhausted products and replenishing the partially etched channel with fresh acid; this procedure is, however, quite cumbersome in the liquid phase. In this paper we present what is to our knowledge the first implementation of the FLICE technique with low-pressure gaseous HF etchant. The use of a gas-phase etchant naturally lends itself to the application of iterative etching techniques, since it is very easy to remove the etchant, by pumping vacuum in the reaction chamber after each etching step. We demonstrate that iterative etching in the gas phase overcomes the limitations of wet etching and allows to achieve nearly constant etching rate for a microchannel length up to ≈3 mm.
Deamination of 2-aminopropanol by ethanolamine ammonia-lyase, an AdoCbl-requiring enzyme. Kinetics and isotope effects for the R and S enantiomers of the substrate (1980)

Both (R)-2-aminopropanol and (S)-2-aminopropanol are substrates for ethanolamine ammonia-lyase, reacting to yield propionaldehyde and ammonia via a common enzyme-bound intermediate. (S)-Propanolamine shows a lower Km and a higher Vmax than the R enantiomer, indicating that the former is a substantially better substrate than the latter. From the isotope effects and other considerations, it appears that the rate-limiting step for (S)-propanolamine is the same as that for ethanolamine, namely, the transfer of hydrogen from the cofactor to the product. In contrast, isotope effects seen with (R)-propanolamine indicate that there are two rate-limiting steps, both located in the segment of the reaction mechanism which is unique to the R enantiomer. One of these is the transfer of hydrogen from the substrate to the cofactor. The other is a subsequent step whose rate is similar to that of the first hydrogen transfer step but which does not involve the rupture of a carbon-hydrogen bond. It is speculated that this second rate-limiting step may have to do with the migration of the amino group.
An association of ABO non‐identical platelet and cryoprecipitate transfusions with altered red cell transfusion needs in surgical patients (2011)

These results, in the context of previous findings, suggest that providing ABO-identical platelets and cryoprecipitate might be associated with reduction in transfusion requirements and improve outcomes in surgical patients.
Localization of Cu/Low-k Interconnect Reliability Defects by Pulsed Laser Induced Technique (2007)

Abstract In this paper, the application of pulsed-TIVA for the localization of Cu/low-k interconnect reliability defects in comb test structures is described. Two types of subtle dielectric defects which are otherwise not detectable with conventional TIVA can be detected with pulsed-TIVA.
Noninvasive Detection of Simian Immunodeficiency Virus Infection in a Wild-Living L'Hoest's Monkey ( Cercopithecus lhoesti ) (2003)

L'Hoest's monkey's (Cercopithecus Ihoesti) are believed to be naturally infected with a simian immunodeficiency virus (SIV), termed SIVIho, but only a handful of isolates, all derived from captive animals from the Democratic Republic of Congo (DCR), have thus far been characterized. Here, we report the noninvasive detection and molecular characterization of SIVIho in a wild L'Hoest's monkey from the Nyungwe Forest in Rwanda. Screening four L'Hoest's monkey fecal samples collected opportunistically as part of a larger noninvasive survey of SIV prevalence in Nyungwe National Park we identified one to be vRNA positive. Reverse transcriptase polymerase chain reaction (RT-PCR) amplification of a subgenomic pol fragment (598 bp) identified a new SIVIho strain (RW30) that differed from previously reported SIVIho isolates in 17-22% of its nucleotide sequence. In a phylogenic tree of partial Pol protein sequences, RW30 fell well within the SIVIho radiation, but was not particularly closely related to any of the other strains. These results provide the first direct evidence that L'Hoewst's monkeys harbor SIVIho in the wild, that infection is prevalent in different areas of the species' habitat, and that geographically diverse SIVIho strains cluster in a single group according to their species of origin. L'Hoest's monkeys represent the third primate species for which the utility of noninvasive SIV testing has been documented.
Quantification in Enzyme‐Linked Immunosorbent Assay of a C3 Neoepitope Expressed on Activated Human Complement Factor C3 (1988)

A sensitive double antibody enzyme-linked immunosorbent assay (ELISA) for quantification of C3 activation products in human plasma, synovial fluid, and cerebrospinal fluid is described. The monoclonal antibody MoAb bH6, which is specific for a C3 neoepitope expressed on C3b, iC3b, and C3c, was used as capture antibody. Detection antibody was a polyclonal rabbit anti-human C3c followed by development with a peroxidase-conjugated anti-rabbit Ig antiserum. The activity in normal human EDTA plasma was 1.5% of that in zymosan-activated serum (ZAS). The interassay and intra-assay coefficients of variation were 15% and 3%, respectively. The lower detection limit was 0.0005% of the ZAS standard. Reference range (1.1-2.1% of ZAS) was obtained by measuring EDTA plasma from 40 healthy blood donors. A positive correlation rs = +0.92; P less than 0.0002) was found between the present assay and an already established C3'g' activation ELISA, when samples from 16 patients were examined in both assays simultaneously. The present assay and an assay detecting the terminal complement complex showed virtually identical activation patterns in consecutively drawn samples from a patient undergoing extracorporal circulation.
Automating Stressmark Generation for Testing Processor Voltage Fluctuations (2013)

Rapid current changes (large di/dt) can lead to significant power supply voltage droops and timing errors in modern microprocessors. To test a processor's resilience to such errors and determine appropriate operating conditions, engineers generally create manual di/dt stressmarks that have large current variations at close to the power distribution network's resonance frequency to induce large voltage droops. This process is time-consuming and might need to be repeated several times to generate appropriate stressmarks for different system conditions (for example, different frequencies or di/dt throttling mechanisms). Furthermore, generating efficient di/dt stressmarks for multicore processors is difficult because of their complexity and synchronization issues. In this article, the authors measure and analyze di/dt issues on state-of-the-art multicore x86 systems. They present an automated di/dt stressmark generation framework called Audit to generate di/dt stressmarks quickly and effectively for multicore systems.
Bioinspired Materials: Nano/Micro‐Manufacturing of Bioinspired Materials: a Review of Methods to Mimic Natural Structures (Adv. Mater. 30/2016) (2016)

Through billions of years of evolution, biological systems have achieved advantageous unification between structure and properties. A review of the nano-/micromanufacturing of bioinspired hybrid materials is presented by J. C. Grunlan and co-workers on page 6292. The cover image shows a live gecko alongside a textured glove inspired by the incredibly adhesive gecko's foot. Graphic design: Igor Kraguljac.
The Chemistry of Pseudomonic Acid. 15. Synthesis and Antibacterial Activity of a Series of 5-Alkyl, 5-Alkenyl, and 5-Heterosubstituted Oxazoles (1996)

The synthesis of a range of 5-alkyl, 5-alkenyl, and 5-heterosubstituted 2-(1-normon-2-yl) oxazoles is described. The antibacterial activity was determined as the minimum inhibitory concentration against a range of Gram-positive and Gram-negative organisms using a standard Agar dilution procedure. Compounds possessing an acid functionality directly on, or close to, the ring were found to be of greatly decreased potency, while increasing lipophilicity with greater chain length led to increased potency of these derivatives.
Photopatterning Enzymes on Polymer Monoliths in Microfluidic Devices for Steady-State Kinetic Analysis and Spatially Separated Multi-Enzyme Reactions (2007)

A method for photopatterning multiple enzymes on porous polymer monoliths within microfluidic devices has been developed and used to perform spatially separated multienzymatic reactions. To reduce nonspecific adsorption of enzymes on the monolith, its pore surface was modified by grafting poly(ethylene glycol), followed by surface photoactivation and enzyme immobilization in the presence of a nonionic surfactant. Characterization of bound horseradish peroxidase (HRP) was carried out using a reaction in which the steady-state profiles of the fluorescent reaction product could be measured in situ and then analyzed using a plug-flow bioreactor model to determine the observed maximum reaction rate and Michaelis constant. The Michaelis constant of 1.9 micro mol/L agrees with previously published values. Mass-transfer limitations were evident at relatively low flow rates but were absent at higher flow rates. Sequential multienzymatic reactions were demonstrated using the patternwise assembly of two- and three-enzyme systems. Glucose oxidase (GOX) and HRP were patterned in separate regions of a single channel, and product formation was analyzed as a function of flow direction. Significant product formation occurred only in the GOX to HRP direction. A three-enzyme sequential reaction was performed using invertase, GOX, and HRP. All possible arrangements of the three enzymes were tested, but significant product formation was only observed when the enzymes were in the correct sequential order. Photopatterning enzymes on polymer monoliths provides a simple technique for preparing spatially localized multiple-enzyme microreactors capable of directional synthesis.
Supplementary Table 1 from IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils (2023)

&lt;p&gt;CRISPR screen results&lt;/p&gt;
A grating-based coupler for fiber-to-silicon waveguide excitation (2004)

Recently there has been a strong trend to fabricate smaller photonic devices. In the literature, the problem of coupling optical fibres with thin semiconductor waveguides has not been solved sufficiently well to obtain both high coupling efficiency and good fabrication tolerances. This paper discusses a new approach, the Dual Grating-Assisted Directional Coupling (DGADC), which can result in a robust and very efficient device, with relaxed fabrication tolerances. Theoretical investigation of the coupler is presented. Coupling efficiency and device length are determined as functions of layer thicknesses and refractive indices, grating periods, depths and duty ratios, and finally wavelength. Fabrication of the coupler is also given, as well as preliminary experimental results.
Sophisticated vector beams produced by photonic-crystal lasers (2010)

Various sophisticated vector beams, which are important for high-resolution microscopy, laser processing, and optical trapping, are successfully produced by the band-edge effect of two-dimensional photonic crystal.
ANALYSES OF CUTTING AND ASPIRATING PROPERTIES OF VITREOUS CUTTERS WITH HIGH-SPEED CAMERA (2008)

Larger cutting port areas and higher duty cycles are associated with higher aspirated volumes of vitreous cutters.
Compression of 2D and 3D navigation video sequences using skip mode masking of static areas (2012)

In order to assert correct behavior of electronics in modern automobiles, extensive tests are conducted. Part of these tests focus on the correct rendering of the navigation systems, including map rotation, content of info boxes and smoothness of frame updates. Test engineers have the need to record the rendered navigation system in live setups (e.g. in moving cars) and evaluate them afterwards. Traditional video encoding produces significant bitrate overhead due to the rotating characteristics of the navigation since rotation is approximated with small macroblock partitioning. In this paper, we show how to construct an encoding scheme specifically designed for encoding of 2D and 3D navigation video sequences. For this purpose we develop a Global Motion Estimation (GME) based on feature matching and model parameter estimation and combine it with an H.264/AVC video encoder as backend. By using skip mode information from the H.264/AVC rate distortion optimization, we are able to stabilize the parameter estimation process even in the presence of large static areas.
Evaluation of PiB visual interpretation with CSF Aβ and longitudinal SUVR in J-ADNI study (2019)

Trinary visual interpretation (negative/equivocal/positive) of amyloid PET imaging reflects quantitative amyloid measurements evaluated with PET and the CSF amyloid test as well as the amyloid accumulation over time evaluated with PET over 3 years. Subjects in the early stage of the AD continuum could be identified with an equivocal scan, because they showed intermediate quantitative amyloid PET, CSF measurements, and the amyloid accumulation over time.
ACM SIGSPATIAL 2016 conference report (2017)

This is the conference report on the 24 th ACM SIGSPATIAL International Conference on Advances in Geographic Information Systems (ACM SIGSPATIAL 2016), held in the San Francisco Bay Area, California, USA, October 31 through November 3, 2016. The conference started as a series of symposia and workshops back in 1993 with the aim of promoting interdisciplinary discussions among researchers, developers, users, and practitioners and fostering research in all aspects of geographic information systems, especially in relation to novel systems based on geospatial data and knowledge. It provides a forum for original research contributions covering all conceptual, design, and implementation aspects of geospatial data ranging from applications, user interfaces and visualization, to data storage, query processing, indexing and data mining. The conference is the premier annual event of the ACM Special Interest Group on Spatial Information (ACM SIGSPATIAL).