gebhart/patrepeval huggingface dataset:
Search for supersymmetry with a compressed mass spectrum in the vector boson fusion topology with 1-lepton and 0-lepton final states in proton-proton collisions at $$ \sqrt{s} $$ = 13 TeV (2019)

A bstract A search for supersymmetric particles produced in the vector boson fusion topology in proton-proton collisions is presented. The search targets final states with one or zero leptons, large missing transverse momentum, and two jets with a large separation in rapidity. The data sample corresponds to an integrated luminosity of 35.9 fb −1 of proton-proton collisions at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 TeV collected in 2016 with the CMS detector at the LHC. The observed dijet invariant mass and lepton-neutrino transverse mass spectra are found to be consistent with the standard model predictions. Upper limits are set on the cross sections for chargino $$ \left({\tilde{\upchi}}_1^{\pm}\right) $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mfenced> <mml:msubsup> <mml:mover> <mml:mi>χ</mml:mi> <mml:mo>˜</mml:mo> </mml:mover> <mml:mn>1</mml:mn> <mml:mo>±</mml:mo> </mml:msubsup> </mml:mfenced> </mml:math> and neutralino $$ \left({\tilde{\upchi}}_2^0\right) $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mfenced> <mml:msubsup> <mml:mover> <mml:mi>χ</mml:mi> <mml:mo>˜</mml:mo> </mml:mover> <mml:mn>2</mml:mn> <mml:mn>0</mml:mn> </mml:msubsup> </mml:mfenced> </mml:math> production with two associated jets. For a compressed mass spectrum scenario in which the $$ {\tilde{\upchi}}_1^{\pm } $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mover> <mml:mi>χ</mml:mi> <mml:mo>˜</mml:mo> </mml:mover> <mml:mn>1</mml:mn> <mml:mo>±</mml:mo> </mml:msubsup> </mml:math> and $$ {\tilde{\upchi}}_2^0 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mover> <mml:mi>χ</mml:mi> <mml:mo>˜</mml:mo> </mml:mover> <mml:mn>2</mml:mn> <mml:mn>0</mml:mn> </mml:msubsup> </mml:math> decays proceed via a light slepton and the mass difference between the lightest neutralino $$ {\tilde{\upchi}}_1^0 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mover> <mml:mi>χ</mml:mi> <mml:mo>˜</mml:mo> </mml:mover> <mml:mn>1</mml:mn> <mml:mn>0</mml:mn> </mml:msubsup> </mml:math> and the mass-degenerate particles $$ {\tilde{\upchi}}_1^{\pm } $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mover> <mml:mi>χ</mml:mi> <mml:mo>˜</mml:mo> </mml:mover> <mml:mn>1</mml:mn> <mml:mo>±</mml:mo> </mml:msubsup> </mml:math> and $$ {\tilde{\upchi}}_2^0 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mover> <mml:mi>χ</mml:mi> <mml:mo>˜</mml:mo> </mml:mover> <mml:mn>2</mml:mn> <mml:mn>0</mml:mn> </mml:msubsup> </mml:math> is 1 (30) GeV, the most stringent lower limit to date of 112 (215) GeV is set on the mass of these latter two particles.
Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of β-tubulin at Cys 12 and suppression of microtubule dynamics (2009)

Bis(4-fluorobenzyl)trisulfide (BFBTS) is a synthetic molecule derived from a bioactive natural product, dibenzyltrisulfide, found in a subtropical shrub, Petiveria allieacea. BFBTS has potent anticancer activities to a broad spectrum of tumor cell lines with IC50 values from high nanomolar to low micromolar and showed equal anticancer potency between tumor cell lines overexpressing multidrug-resistant gene, MDR1 (MCF7/adr line and KBv200 line), and their parental MCF7 line and KB lines. BFBTS inhibited microtubule polymerization dynamics in MCF7 cells, at a low nanomolar concentration of 54 nmol/L, while disrupting microtubule filaments in cells at low micromolar concentration of 1 micromol/L. Tumor cells treated with BFBTS were arrested at G2-M phase, conceivably resulting from BFBTS-mediated antimicrotubule activities. Mass spectrometry studies revealed that BFBTS bound and modified beta-tubulin at residue Cys12, forming beta-tubulin-SS-fluorobenzyl. The binding site differs from known antimicrotubule agents, suggesting that BFBTS functions as a novel antimicrotubule agent. BFBTS at a dose of 25 mg/kg inhibited tumor growth with relative tumor growth rates of 19.91%, 18.5%, and 23.42% in A549 lung cancer, Bcap-37 breast cancer, and SKOV3 ovarian cancer xenografts, respectively. Notably, BFBTS was more potent against MDR1-overexpressing MCF7/adr breast cancer xenografts with a relative tumor growth rate of 12.3% than paclitaxel with a rate of 43.0%. BFBTS displays a novel antimicrotubule agent with potentials for cancer therapeutics.
ChemInform Abstract: Molecular and Crystal Engineering in the Design of Organic Solids with Ferromagnetic Intermolecular Interactions (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Characterization of the Intracellular Deproteinized Relaxed Circular DNA of Hepatitis B Virus: an Intermediate of Covalently Closed Circular DNA Formation (2007)

Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is formed by conversion of capsid-associated relaxed circular DNA (rcDNA) via unknown mechanisms and exists in the nucleus of the infected hepatocyte as a minichromosome that serves as the transcription template for viral RNAs. To study the molecular pathway of cccDNA formation and its regulation by viral and cellular factors, we have established a cell line that supports the replication of an envelope protein-deficient HBV genome in a tetracycline-inducible manner. Following induction of HBV replication, the cells accumulate higher levels of cccDNA as well as larger amounts of deproteinized rcDNA (DP-rcDNA) than cells that replicate wild-type HBV genomes. These results indicate that HBV envelope proteins negatively regulate cccDNA formation, and conversion of DP-rcDNA into cccDNA is a rate-limiting step of cccDNA formation in HepG2 cells. Detailed analyses reveal the following: (i) DP-rcDNA exists in both cytoplasm and nucleus; (ii) while nuclear DP-rcDNA is sensitive to DNase I digestion, a small fraction of cytoplasmic DP-rcDNA is DNase I resistant; (iii) both DNase I-sensitive and -resistant cytoplasmic DP-rcDNAs cosediment with capsids and can be immunoprecipitated with HBV core antibody; and (iv) a primer extension assay maps the 5' end of the minus strand of DP-rcDNA at the authentic end of virion rcDNA. Hence, our results favor a hypothesis that the removal of viral polymerase protein covalently linked to the 5' end of the minus-strand DNA occurs inside the capsid in the cytoplasm and most possibly via a reaction that cleaves the phosphodiester bond between the tyrosine of the polymerase and the 5' phosphoryl group of minus-strand DNA.
ChemInform Abstract: Metal‐Templated Enantioselective Enamine/H‐Bonding Dual Activation Catalysis. (2015)

Abstract The Ir(III) complex IRC constitutes one of the most efficient catalyst for the enantioselective α‐amination of aldehydes with catalyst loadings down to 0.1 mol%.
Measuring the tolerance of the genetic code to altered codon size (2021)

Summary Protein translation using four-base codons occurs in both natural and synthetic systems. What constraints contributed to the universal adoption of a triplet-codon, rather than quadruplet-codon, genetic code? Here, we investigate the tolerance of the E. coli genetic code to tRNA mutations that increase codon size. We found that tRNAs from all twenty canonical isoacceptor classes can be converted to functional quadruplet tRNAs (qtRNAs), many of which selectively incorporate a single amino acid in response to a specified four-base codon. However, efficient quadruplet codon translation often requires multiple tRNA mutations, potentially constraining evolution. Moreover, while tRNAs were largely amenable to quadruplet conversion, only nine of the twenty aminoacyl tRNA synthetases tolerate quadruplet anticodons. These constitute a functional and mutually orthogonal set, but one that sharply limits the chemical alphabet available to a nascent all-quadruplet code. Our results illuminate factors that led to selection and maintenance of triplet codons in primordial Earth and provide a blueprint for synthetic biologists to deliberately engineer an all-quadruplet expanded genetic code.
Whole-Cell Electrochemical Biosensor Integrating Microbes with Si Nanowire-Forest (2017)

In the current work, the synergetic effect of microbial cells and functional nanostructures, such as highly disordered Si nanowires (SiNW-forest), has been exploited to develop a novel whole-cell biosensor. E.Coli microbial cells, expressing and displaying recombinant ZZ proteins, were immobilized onto SiNW-forest electrode. The existence of the microbial cells was verified visually by scanning electron microscopy, and viable counting, and electrochemically using impedance spectroscopy (EIS). The electrochemical impedance spectra show a clear dependence on the number of the microbial cells by allowing the detection of different number of cells in the range between 103 and 107. In addition, the EIS investigation suggests further decrease in the detected cells concentration to be possible.
Data from A Five-Gene and Corresponding Protein Signature for Stage-I Lung Adenocarcinoma Prognosis (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Identification of effective markers for outcome is expected to improve the clinical management of non–small cell lung cancer (NSCLC). Here, we assessed in NSCLC the prognostic efficacy of genes, which we had previously found to be differentially expressed in an &lt;i&gt;in vitro&lt;/i&gt; model of human lung carcinogenesis.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Prediction algorithms and risk-score models were applied to the expression of the genes in publicly available NSCLC expression data sets. The prognostic capacity of the immunohistochemical expression of proteins encoded by these genes was also tested using formalin-fixed paraffin-embedded (FFPE) tissue specimens from 156 lung adenocarcinomas and 79 squamous cell carcinomas (SCCs).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; The survival of all-stages (&lt;i&gt;P&lt;/i&gt; &lt; 0.001, HR = 2.0) or stage-I (&lt;i&gt;P&lt;/i&gt; &lt; 0.001, HR = 2.84) adenocarcinoma patients that expressed the five-gene &lt;i&gt;in vitro&lt;/i&gt; lung carcinogenesis model (FILM) signature was significantly poorer than that of patients who did not. No survival differences were observed between SCCs predicted to express or lack FILM signature. Moreover, all stages (&lt;i&gt;P&lt;/i&gt; &lt; 0.001, HR = 1.95) or stage-I (&lt;i&gt;P&lt;/i&gt; = 0.001, HR = 2.6) adenocarcinoma patients predicted to be at high risk by FILM transcript exhibited significantly worse survival than patients at low risk. Furthermore, the corresponding protein signature was associated with poor survival (all stages, &lt;i&gt;P&lt;/i&gt; &lt; 0.001, HR = 3.6; stage-I, &lt;i&gt;P&lt;/i&gt; &lt; 0.001, HR = 3.5; stage-IB, &lt;i&gt;P&lt;/i&gt; &lt; 0.001, HR = 4.6) and mortality risk (all stages, &lt;i&gt;P&lt;/i&gt; = 0.001, HR = 4.0; stage-I, &lt;i&gt;P&lt;/i&gt; = 0.01, HR = 3.4; stage-IB, &lt;i&gt;P&lt;/i&gt; &lt; 0.001, HR = 7.2) in lung adenocarcinoma patients.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our findings highlight a gene and corresponding protein signature with effective capacity for identification of stage-I lung adenocarcinoma patients with poor prognosis that are likely to benefit from adjuvant therapy. &lt;i&gt;Clin Cancer Res; 17(6); 1490–501. ©2010 AACR.&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Fabrication of Uniform Gratings on Composite Semiconductors Using UV Nanoimprint Lithography (2009)

A fabrication method of uniform gratings on composite semiconductors using ultraviolet nanoimprint lithography (UV-NIL) is described. Since the grating pattern was batch transferred to the resin on substrates in this process, a high throughput fabrication process is expected. Both the dry etching process and the wet etching process can be performed for composite semiconductors patterning. The uniformity of the pattern height on a 3 inch GaAs substrate is better than the standard deviation of 2.6.
Efficient siRNA delivery by novel PTD-DRBD fusion proteins (2010)

Comment on: Eguchi A, et al. Nat Biotechnol 2009; 27:567-71.
Serum lipid profiles, total tract nutrient digestibility, and gastrointestinal tolerance by dogs of α-cyclodextrin (2015)

The objectives were to quantify gastrointestinal tolerance, total tract nutrient digestibility, and serum lipid profiles of dogs as affected by α-cyclodextrin (ACD) supplementation and to validate the accuracy of fat analyses techniques using novel ACD-fat complexes. The ACD was hydrolyzed and free sugars and hydrolyzed monosaccharides were quantified using high performance liquid chromatography. Known amount of fats were complexed with ACD, and fat content of complexes were determined using the ether extraction and acid-hydrolyzed fat methods. Nine mixed-breed hounds were used in a crossover design with 3 periods of 10 d each, including 6 d for diet adaptation and 4 d for fecal collection. Dogs were fed twice daily a diet with poultry byproduct meal and brewer's rice as the main ingredients, and chromic oxide (0.2%) was included as a digestion marker. Dogs were supplemented with either 0, 3, or 6 g of ACD diluted in 15 mL of water twice per day for a total of 0, 6, and 12 g ACD per day. The ACD had a very low free sugar concentration and, once hydrolyzed, released only glucose, as expected. Average daily food intake, fecal output (DM basis), and fecal scores were not significantly different among treatments. Body weight and condition score and serum triglycerides and cholesterol concentrations remained unaltered throughout the duration of the experiment. Dry matter, OM, and fat digestibility coefficients were lower (P < 0.05) for both treatment groups compared to the control. The acid-hydrolyzed fat method was valid to measure fat that was bound to ACD. Intake of ACD lowered fat digestibility somewhat but not to the extent previously reported, without affecting serum lipid concentrations or outcomes related to tolerance. Therefore, ACD supplementation resulted in a small decrease in fat digestibility, but ACD supplementation might have potential in modifying serum lipid profiles.
CLAI: A Platform for AI Skills on the Command Line. (2020)

This paper reports on the open source project CLAI (Command Line AI), aimed at bringing the power of AI to the command line interface. The platform sets up the CLI as a new environment for AI researchers to conquer by surfacing the command line as a generic environment that researchers can interface to using a simple sense-act API much like the traditional AI agent architecture. In this paper, we discuss the design and implementation of the platform in detail, through illustrative use cases of new end user interaction patterns enabled by this design, and through quantitative evaluation of the system footprint of a CLAI-enabled terminal. We also report on some early user feedback on its features from an internal survey.
Hybrid microstrip/NRD-guide filter with enhanced upside stop-band rejection (2000)

This paper presents a new technique relative to the design of hybrid planar/NRD-guide filter for millimeter-wave integrated circuits and systems. Spurious moding problems of the previous design approaches are studied and a new mode-suppressing scheme is proposed and used in this filter design. The filter performance is effectively improved, especially for the upside stop-band rejection. It is shown that both the hybrid planar/NRD transition and the developed mode suppressor are able to reduce all the spurious modes to a required level. This design technique provides a useful solution to higher performance planar NRD-guide filter at millimeter-wave frequency.
Aminotriazole Mn(I) Complexes as Effective Catalysts for Transfer Hydrogenation of Ketones (2018)

A catalytic system based on complexes comprising abundant and cheap manganese together with readily available aminotriazole ligands is reported. The new Mn(I) complexes are catalytically competent in transfer hydrogenation of ketones with 2-propanol as hydrogen source. The reaction proceeds under mild conditions at 80 °C for 20 h with 3 % of catalyst loading using either KO <sup><i>t</i></sup> Bu or NaOH as base. Good to excellent yields were obtained for a wide substrate scope with broad functional group tolerance. The obtained results by varying the substitution pattern of the ligand are consistent with an out-sphere mechanism for the H-transfer.
Synthesis of 1,2‐Disubstituted‐3‐alkylidenylpyrrolidines via a One‐Pot Three‐Component Reaction. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Phase I-II study of mitomycin C topical therapy for low-grade, low stage transitional cell carcinoma of the bladder: an interim report. (1980)

Intravesical mitomycin C therapy was administered to 63 patients with noninvasive bladder carcinoma in a phase I-II study. Doses ranged from 20 to 60 mg once a week for 8 weeks. The overall response rate was 67% including a complete remission rate of 45%. The median duration of complete remission for the two lowest dose groups was > 14 months, with a range of 1-36+ months. Followup is not yet adequate to determine the median duration of complete remission for the higher dose groups. No bone marrow suppression or other systemic toxic effects were noted. Adverse effects were localized and occurred infrequently. No mitomycin C was detected in serial serum samples after intravesical instillation.
Discovery of a Potent and Isoform-Selective Targeted Covalent Inhibitor of the Lipid Kinase PI3Kα (2013)

PI3Kα has been identified as an oncogene in human tumors. By use of rational drug design, a targeted covalent inhibitor 3 (CNX-1351) was created that potently and specifically inhibits PI3Kα. We demonstrate, using mass spectrometry and X-ray crystallography, that the selective inhibitor covalently modifies PI3Kα on cysteine 862 (C862), an amino acid unique to the α isoform, and that PI3Kβ, -γ, and -δ are not covalently modified. 3 is able to potently (EC(50) < 100 nM) and specifically inhibit signaling in PI3Kα-dependent cancer cell lines, and this leads to a potent antiproliferative effect (GI(50) < 100 nM). A covalent probe, 8 (CNX-1220), which selectively bonds to PI3Kα, was used to investigate the duration of occupancy of 3 with PI3Kα in vivo. This is the first report of a PI3Kα-selective inhibitor, and these data demonstrate the biological impact of selectively targeting PI3Kα.
Measurement system for 2D magnetic properties of electrical steel sheets: design and performance (2000)

2-DM2000
Low threshold 1260nm (GaIn) (NAs) semiconductor disk laser (2007)

Low threshold cw laser emission from a semiconductor disk laser emitting at 1260nm was demonstrated. Using high quality metal-organic vapor phase epitaxy (GaIn) (NAs) material, nonradiative processes could be minimized. As a consequence, threshold pump power densities have been reduced down to 5kW∕cm2. The capture efficiency of carriers into the quantum wells was found to be uncritical.
Photopumped 1.56 {micro}m vertical cavity surface emitting laser with AlGaAsSb/AlAsSb distributed Bragg reflectors (1998)

The authors report 77K operation of an optically pumped vertical cavity surface emitting laser with an Sb-based cavity. The structure consists of 15 and 20 pair AlGaAsSb/AlAsSb top and bottom reflectors and a bulk InGaAs active region.
High-throughput automated microfluidic sample preparation for accurate microbial genomics (2017)

Low-cost shotgun DNA sequencing is transforming the microbial sciences. Sequencing instruments are so effective that sample preparation is now the key limiting factor. Here, we introduce a microfluidic sample preparation platform that integrates the key steps in cells to sequence library sample preparation for up to 96 samples and reduces DNA input requirements 100-fold while maintaining or improving data quality. The general-purpose microarchitecture we demonstrate supports workflows with arbitrary numbers of reaction and clean-up or capture steps. By reducing the sample quantity requirements, we enabled low-input (∼10,000 cells) whole-genome shotgun (WGS) sequencing of Mycobacterium tuberculosis and soil micro-colonies with superior results. We also leveraged the enhanced throughput to sequence ∼400 clinical Pseudomonas aeruginosa libraries and demonstrate excellent single-nucleotide polymorphism detection performance that explained phenotypically observed antibiotic resistance. Fully-integrated lab-on-chip sample preparation overcomes technical barriers to enable broader deployment of genomics across many basic research and translational applications.
Sorbents (2009)

Abstract Chapter 23 discusses sorbents, including removal of target substances by sorbent in sepsis, selectivity of sorbent used for the removal of target substance, efficiency of adsorption, and typical modalities of utilization of sorbents.
Properties of Ruthenium Films Prepared by Liquid Source Metalorganic Chemical Vapor Deposition Using Ru(EtCp)2 with Tetrahydrofuran Solvent (2000)

Pure Ru thin films were deposited on SiO 2 /Si substrates, using Ru(C 2 H 5 C 5 H 4 ) 2 with C 4 H 8 O (THF) solvent, by liquid source metalorganic chemical vapor deposition. The Ru single phase could be obtained under all growth conditions. For temperatures below 350°C, deposition occurred in the surface reaction region because the kinetics increased exponentially as a function of the deposition temperature with an activation energy of about 1.1 eV. Above 350°C, the deposition was controlled by the mass transport process. Step coverage for the Ru thin films deposited at 300–325°C with an aspect ratio of 3.3 was about 100%. The Ru thin films grown at 325°C showed a dense and smooth microstructure and had resistivities of &lt;100 µΩ·cm.
Systematic Review of Emergency Physician–performed Ultrasonography for Lower‐Extremity Deep Vein Thrombosis (2008)

Systematic review of six studies suggests that EPPU may be accurate for the diagnosis of DVT compared with radiology-performed ultrasound (US). However, given the methodologic limitations identified among the primary studies, the estimates of diagnostic test performance may be overly optimistic. Further research into EPPU for suspected DVT is needed before it can be adopted into routine clinical practice.
Defining new pathogens and nonculturable infectious agents associated with inflammatory bowel disease (2000)

The causes of inflammatory bowel disease remain uncertain, but increasing evidence supports roles for two pathogenic processes: genetic susceptibility in the host and an aberrant host response to enteric bacteria. Here, we review studies showing that the pathogenesis of inflammatory bowel disease involves both bacterial agents and genetic susceptibilities. We discuss the roles of known and novel commensal intestinal bacteria in the pathogenesis of inflammatory bowel disease and the various recombinant approaches used to identify these pathogens.
Photoinitiated polymerization of vinyl monomers by benzophenone t‐butyl peresters (1983)

Abstract Benzophenone peresters undergo efficient photodecomposition when irradiated at 366 nm. This article reports peresters derived from benzophenone p , p ′‐dicarboxylic acid 1 which may produce radicals at two different centers in the same molecule. These peresters represent a unique new example of an efficient photoinitiator for acrylate and styrene polymerization. magnified image