gebhart/patrepeval huggingface dataset:
Workflows over Workflows: Practical Experiences with the Integration of SAP R/3 Business Workflow in WISE. (1999)

Business processes within companies are in general well established and supported by commercially available workflow management systems. However, when processes span multiple companies (such as, for instance, in the case of virtual enterprises or in business to business electronic commerce), software support quite is limited. In such cases, processes need to be implemented on top of already existing systems. The WISE project addresses this problem and provides adequate infrastructure to support the whole life-cycle of virtual enterprise processes, including the integration of legacy systems, especially of workflow management systems. In this paper, we describe our experience with the integration of SAP R/3 Business Workflows into WISE. In addition, and since an important characteristics of the WISE system is the enactment of processes with execution guarantees, we also discuss the provision of execution guarantees when external systems like SAP R/3 Business Workflows are involved.
Massive MIMO With Max-Min Power Control in Line-of-Sight Propagation Environment (2017)

Massive MIMO relies on the asymptotic orthogonality of channel vectors to different users. For M service antennas, the expected correlation between a pair of channel vectors under line-of-sight (LoS) conditions decreases at least as fast as log(M)/M, while in independent and identically distributed (iid) Rayleigh fading, it decreases much slower at 1/√M, but the variance is higher under LoS. This signifies that typically channel vectors are more nearly orthogonal under LoS, but with a non-negligible probability, they can have an anomalously large correlation. A single-cell analysis discloses that Massive MIMO with max-min power control performs comparably under LoS and iid Rayleigh, when a simple algorithm is applied under LoS to drop a small number of high-correlation users from service.
Characterization of Liposomes Using Quantitative Phase Microscopy (QPM) (2021)

The rapid development of nanomedicine and drug delivery systems calls for new and effective characterization techniques that can accurately characterize both the properties and the behavior of nanosystems. Standard methods such as dynamic light scattering (DLS) and fluorescent-based assays present challenges in terms of system's instability, machine sensitivity, and loss of tracking ability, among others. In this study, we explore some of the downsides of batch-mode analyses and fluorescent labeling, while introducing quantitative phase microscopy (QPM) as a label-free complimentary characterization technique. Liposomes were used as a model nanocarrier for their therapeutic relevance and structural versatility. A successful immobilization of liposomes in a non-dried setup allowed for static imaging conditions in an off-axis phase microscope. Image reconstruction was then performed with a phase-shifting algorithm providing high spatial resolution. Our results show the potential of QPM to localize subdiffraction-limited liposomes, estimate their size, and track their integrity over time. Moreover, QPM full-field-of-view images enable the estimation of a single-particle-based size distribution, providing an alternative to the batch mode approach. QPM thus overcomes some of the drawbacks of the conventional methods, serving as a relevant complimentary technique in the characterization of nanosystems.
Target Classification Based On Kinematic Data From AIS/ADS-B, Using Statistical Features Extraction and Boosting (2019)

We propose a simple yet efficient method to classify multivariate time series with an arbitrary number of timesteps, and we apply it to the classification of targets (either aircrafts or vessels) using kinematic data only. We use data obtained from the Automatic Identification System (AIS) and the Automatic Dependent Surveillance-Broadcast (ADS-B) to get labelled trajectories for supervised learning, as a proof of concept for later use on radar tracks. The method consists in extracting statistical features from each temporal variable (speed, acceleration, etc.), and then feeding them to a Gradient Boosting classifier. We show that the performance of this method is on par with the state of the art, as the classification accuracy is close to 86AIS data, and thus that it could be used in radars for the classification of targets based on their trajectory.
The T Cell Response to Art v 1, the Major Mugwort Pollen Allergen, Is Dominated by One Epitope (2002)

Mugwort (Artemisia vulgaris) pollen allergens represent the main cause of pollinosis in late summer in Europe. At least 95% of sera from mugwort pollen-allergic patients contain IgE against a highly glycosylated 24- to 28-kDa glycoprotein. Recently, this major allergen, termed Art v 1, was characterized, cloned in Escherichia coli, and produced in recombinant form. In the present study we characterized and compared the T cell responses to natural (nArt v 1) and recombinant Art v 1 (rArt v 1). In vitro T cell responses to nArt v 1 and rArt v 1 were studied in PBMC, T cell lines (TCL), and T cell clones (TCC) established from PBMC of mugwort-allergic patients. Stimulation of PBMC or allergen-specific TCL with either nArt v 1 or rArt v 1 resulted in comparable proliferative T cell responses. Eighty-five percent of the TCC reactive with rArt v 1 cross-reacted with the natural protein. The majority of the CD4(+)CD8(-)TCR alphabeta(+) Art v 1-specific TCC, obtained from 10 different donors, belonged to the Th2 phenotype. Epitope mapping of TCL and TCC using overlapping peptides revealed a single immunodominant T cell epitope recognized by 81% of the patients. Inhibition experiments demonstrated that the presentation of this peptide is restricted by HLA-DR molecules. In conclusion, the T cell response to Art v 1 is characterized by one strong immunodominant epitope and evidently differs from the T cell responses to other common pollen allergens known to contain multiple T cell epitopes. Therefore, mugwort allergy may be an ideal candidate for a peptide-based immunotherapy approach.
Metastatic Carcinoid Presenting as a Breast Lesion (2010)

Metastasis to the breast is a rare occurrence, constituting fewer than 2% of all breast tumours. Of all metastatic tumours in the breast, most arise from contralateral breast primaries. Other reported primary solid tumour sites include melanoma; lung, gastric, and renal cancers; and approximately 29 cases of carcinoid tumour.Ambiguous presentations and an absence of carcinoid syndrome features make accurate radiographic and histologic assessment of breast carcinoids challenging. Here, we report the case of a 52-year-old woman who presented with a mammographic abnormality in the left breast. Excisional biopsy revealed histopathology consistent with carcinoid. After an exhaustive work-up, carcinoid within the terminal ileum was ultimately identified, and the woman was diagnosed with metastatic breast carcinoid, an exceedingly rare entity. This paper describes the common mammographic, cytologic, and immunohistochemical features typical of metastatic breast carcinoid tumours, together with their common clinical features, prognosis, and treatment options.
Differential expression of interleukin‐32 in chronic rhinosinusitis with and without nasal polyps (2011)

Overproduction of IL-32 may be involved in the pathogenesis of CRS, although the role of IL-32 in the inflammation in CRSsNP and CRSwNP may be different.
Performance Comparison of Duobinary and DQPSK Modulation Formats for Mixed 10/40-Gb/s WDM Transmission on SMF and LEAF Fibers (2007)

Duobinary and DQPSK modulation formats are considered as the best candidates for deployment of 40 Gb/s technology on existing 10 Gb/s WDM transmission systems. We show here that DQPSK modulation format is more adapted for mixed 10/40-Gb/s WDM transmission on SMF whereas duobinary is particularly efficient on LEAFtrade fiber.
Non-magnetic substrates for low cost YBCO coated conductors (2001)

CuNiAl and NiCr alloys were made and processed to non-magnetic, bi-axially textured substrates. Epitaxial YSZ and YBCO were deposited by pulsed laser deposition on the CuNiAl. Samples were cross sectioned and investigated with TEM. It appears that Al forms a thin oxide layer at the CuNiAl surface that acts as a template for the subsequent YSZ layer. The 1.2 /spl mu/m YBCO layer had a current density of 0.16 MA/cm/sup 2/ at 75 K and self field. On the NiCr substrates an Y/sub 2/O/sub 3/ seed layer was deposited with E-beam evaporation, followed by RF sputter deposition of YSZ and a CeO/sub 2/ cap layer. These substrates were coated with a 0.4 /spl mu/m YBCO layer using a trifluoroacetate solution, a very cost effective metal-organic deposition process. These samples carried critical currents exceeding 0.7 MA/cm/sup 2/ at 77 K, self field.
Correlation between SiO2 growth rate and difference in electronegativity of metal–oxide underlayers for plasma enhanced atomic layer deposition using tris(dimethylamino)silane precursor (2020)

The growth rate of an SiO2 film on various metal–oxide (M–O) underlayers by plasma-enhanced atomic layer deposition (ALD) using tris(dimethylamino)silane precursor and O2 plasma gas is systematically investigated, and the effect of the difference in the electronegativity of the M–O underlayer on the ALD-SiO2 growth mechanism is also discussed. All data for the ALD-SiO2 film thickness on HfO2, TiO2, Al2O3, and SiO2 underlayers satisfied a linear relationship as a function of the ALD cycle. The growth per cycle (GPC) value of the ALD-SiO2 film increased in the following order: SiO2 (0.043 nm/cycle) &amp;lt; Al2O3 (0.14) &amp;lt; TiO2 (0.17) &amp;lt; HfO2 (0.22). On the other hand, the negative charge concentration of oxygen atoms in the M–O underlayer becomes higher in the following order: Si–O (1.76 eV) &amp;lt; Al–O (2.03) &amp;lt; Ti–O (2.18) &amp;lt; Hf–O (2.27) due to the electronegativity difference between the Si, Al, Ti, Hf, and O elements of the M–O underlayer. A correlation between the GPC of the ALD-SiO2 film and the difference in the electronegativity of the M–O underlayer was also determined.
Radioresistant tumor cell lines derived from head and neck radiation failures (1989)

We studied the in vitro radiobiological parameters of 16 human head and neck squamous cell carcinoma tumor cell lines cultured from patients who suffered local failure after a curative course of radiotherapy. The radiobiological parameters determined included D0, n, and D. When compared with in vitro radiobiological parameters of tumor cells cultured from head and neck cancer patients prior to radiotherapy, human sarcoma cell lines, and normal human diploid fibroblasts studied in our laboratory (as well as other human tumor cell lines reported in the literature), tumor cells derived from radiotherapy failures on average are resistant to the cytotoxic effects of ionizing radiation.
Dynamic HTTP download scheduling with respect to energy consumption (2013)

Mobile devices, in particular smartphones, are battery powered. As their small size limits their energy capacity, an intelligent and energy-saving use of resources is crucial for the mobile user experience. Especially energy saving while sending and receiving data becomes important due to the always-on nature of smartphones. One solution for a sophisticated resource usage in wireless access networks is to tailor resource management to applications. The advantage of such mechanisms is to be able to address both the perceived quality of the users and the energy consumption of mobile devices at the same time. We propose several traffic scheduling algorithms for HTTP file download in wireless networks based on this application-aware paradigm. The core idea is to use download scheduling that avoids parallel transmissions and, in contrast, favors sequential transmission.We have implemented and measured the algorithms in a wireless mesh network. The evaluation results quantify the gain of an application-aware resource management with respect to quality of experience and energy consumption.
Magnesium enrichment and distribution in plants (2003)

Food products enriched with stable isotopes are used in nutrition to study the metabolic fate of nutrients in humans. This study reports on the labeling of green beans, white beans, soybeans and wheat with a stable isotope of magnesium (25Mg) obtained in greenhouse conditions for further studies on magnesium bioavailability. Soybean and green bean are the most efficient plant species to obtain large amounts of edible parts rapidly with a minimum loss of labeled Mg in other parts of the plants. The results obtained showed that a relatively high percentage of the magnesium found in seeds (grains/beans) can come from the redistribution of magnesium previously accumulated in other organs.
Folding of Fibroblast Growth Factor 1 Is Critical for Its Nonclassical Release (2016)

Fibroblast growth factor 1 (FGF1), a ubiquitously expressed pro-angiogenic protein that is involved in tissue repair, carcinogenesis, and maintenance of vasculature stability, is released from the cells via a stress-dependent nonclassical secretory pathway. FGF1 secretion is a result of transmembrane translocation of this protein. It correlates with the ability of FGF1 to permeabilize membranes composed of acidic phospholipids. Like several other nonclassically exported proteins, FGF1 exhibits β-barrel folding. To assess the role of folding of FGF1 in its secretion, we applied targeted mutagenesis in combination with a complex of biophysical methods and molecular dynamics studies, followed by artificial membrane permeabilization and stress-induced release experiments. It has been demonstrated that a mutation of proline 135 located in the C-terminus of FGF1 results in (i) partial unfolding of FGF1, (ii) a decrease in FGF1's ability to permeabilize bilayers composed of phosphatidylserine, and (iii) drastic inhibition of stress-induced FGF1 export. Thus, folding of FGF1 is critical for its nonclassical secretion.
<title>Preisach modeling and compensation for smart material hysteresis</title> (1995)

Many of the Smart materials being investigated (e.g., Shape Memory Alloys (SMAs), piezoceramics, and magnetostrictives) exhibit significant hysteresis effects, especially when driven with large control signals. In this paper the similarity between the microscopic domain kinematics that generate static hysteresis effects, or ferromagnetics, piezoceramics and SMAs is noted. The Preisach independent domain hysteresis model, and its derivatives, have been shown to be a comprehensive class of hysteresis operator that captures the major features of ferromagnetic hysteresis, and hence it is proposed here as a suitable model for piezoceramic and SMA hysteresis also. This basic Preisach model is used to model piezoceramic sheet actuators bonded to a flexible aluminum beam, and a Nitinol SMA wire muscle that applies a bending force to the end of the beam. A numerical inverse Preisach hysteresis series compensator is also proposed and applied in a real time experiment thereby reducing the apparent nonlinear hysteresis effects for the piezoceramic actuator quasi-static case.
Imaging and Quantitation of a Tissue-Selective Lanthanide Chelate Using an Endoscopic Fluorometer (1998)

Tissue spectroscopy and endoscopy are combined with a tissue site-selective fluorescent probe molecule to demonstrate in vitro, spatial, remote, quantitative imaging of the rat small intestine. The probe molecule employed, Tb-3,6,9-tris(methylene phosphonic acid n-butyl ester)-3,6,9,15-tetraaza-bicyclo[9.3.1]pentadeca-1(15),11,13-triene (Tb-PCTMB), is shown to bind with the small intestine and provide improved image contrast. High sensitivity is possible due to the absorption-emission Stokes's shift exhibited by the Tb-PTCMB complex. Excitation is centered near 270 nm and multifeatured emission is observed at 490, 550, 590, and 625 nm. Sprague-Dawley rats were dosed with the Tb-PTCMB complex, which shows biodistribution, leading to preferential binding to the inner surface of the small intestine. It is shown that the fluorescent image, taken at 550 nm, can be used to quantify the amount of Tb-PCTMB present in an excised tissue sample. The 3σ detection limits are found to be in the femtomole range. An optical mass balance for Tb-PCTMB-dosed small intestine is performed and along with radiotracer biodistribution, demonstrates that approximately 40% of the marker probe resides in the endothelial tissue of the small intestine inner lumen. This result is of particular interest since most adult colon cancers develop in this region. These results demonstrate the ability to perform spatial, quantitative, in vitro, endoscopic imaging of a complex biological sample using a probe marker. © 1998 Society of Photo-Optical Instrumentation Engineers.
Inflamed-phenotype gene expression signatures to predict benefit from the anti-PD-1 antibody pembrolizumab in PD-L1+ head and neck cancer patients. (2015)

6017 Background: Immunotherapy with anti-PD-1 checkpoint blockade shows encouraging activity in head and neck squamous cell carcinoma (HNSCC). We tested 4 multi-gene expression signatures previously derived in melanoma patients (pts) in PD-L1+HNSCC pts from the KEYNOTE-012 (NCT01848834) study as candidate predictive biomarkers. Methods: 43 of 61 pembrolizumab-treated patients had RNA expression profiling and survival data; 40 were evaluable for objective response. FFPE-extracted RNA was analyzed on the NanoString nCounter system. Four previously established gene signatures (1) “interferon-γ,” (2) “TCR signaling,” (3) “expanded-immune,” and (4) “de novo” were examined as possible predictors for formal hypothesis testing prior to unblinding clinical outcome data. Results: Overall response (OR) rate was 9/40 = 23%. Three signatures showed significant (P < 0.05) association with OR; all 4 signatures showed strong associations (P< 0.005) with PFS. Signature scores and PFS readily segregated into 2 groups (>5 versus <5 months PFS). Using an optimal cutoff for the top-performing interferon-γ signature, positive predictive value (PPV) for response was 40.0%, and negative predictive value (NPV) was 95.0%; AUC = 0.80 [95% CI, 0.61-0.95]. When evaluating the individual signature genes, T-cell–mediated interferon-γ inducible MHC-II expression appeared to be the immune biological connection. Interferon-γ signature correlated strongly with the previously independently discovered inflamed/mesenchymal HNSCC intrinsic subtype (Keck/Seiwert CCR 2015) (R = 0.9). Conclusions: “Inflamed phenotype” signatures are strong predictors of clinical benefit from anti-PD-1 treatment for HNSCC even among a group of patients already considered to be PD-L1+. Clinical trial information: NCT01848834. Nominal 1-sided P valuea Signature OR N = 40 PFS N = 43 IFN-γ (6-gene) 0.005 < 0.001 TCR signaling (13-gene) 0.071 0.002 Expanded-immune (18-gene) 0.015 < 0.001 De novo (33-gene) 0.018 < 0.001 aFrom logistic or Cox regression for overall response and progression-free survival, respectively.
Association of the low-activity COMT 158Met allele with ADHD and OCD in subjects with velocardiofacial syndrome (2006)

Velocardiofacial syndrome (VCFS) is caused by a microdeletion in chromosome 22 and is a risk factor for the development of schizophrenia and other psychiatric disorders. The catechol-O-methyltransferase (COMT), residing in the 22q11.2 microdeletion region, is a major candidate gene for genetic susceptibility to neuropsychiatric disorders in VCFS. Individuals with VCFS carrying the low-activity allele (COMTL) are expected to have the lowest possible COMT activity since they have only a single copy of the gene. We explored the possibility that COMTL is associated with psychiatric disorders commonly found in VCFS. Fifty-five unrelated individuals with VCFS underwent psychiatric evaluation and were genotyped for the COMT 158Val/Met polymorphism coding for COMT high/low-activity alleles. The COMTL allele was significantly more prevalent in VCFS subjects with attention deficit hyperactivity disorder (ADHD) (73.9% vs. 33.3%, OR 5.67, chi2=7.76, p=0.005) and obsessive-compulsive disorder (OCD) (78.6% vs. 33.3%, OR 7.33, chi2=7.24, p=0.007) than in the control group (VCFS subjects without OCD, ADHD and schizophrenia/schizoaffective (SZ/SZaff) disorder). The results of this study suggest that greatly reduced COMT activity, as expected in VCFS COMTL individuals may be a risk factor for psychiatric sequelae in this population. Future longitudinal studies focusing on additional COMT polymorphic sites and other candidate genes from the deleted region will elucidate the molecular pathways leading to schizophrenia and other psychiatric disorders in VCFS.
Not to Overfit or Underfit the Source Domains? An Empirical Study of Domain Generalization in Question Answering (2022)

Machine learning models are prone to overfitting their training (source) domains, which is commonly believed to be the reason why they falter in novel target domains. Here we examine the contrasting view that multi-source domain generalization (DG) is first and foremost a problem of mitigating source domain underfitting: models not adequately learning the signal already present in their multi-domain training data. Experiments on a reading comprehension DG benchmark show that as a model learns its source domains better -- using familiar methods such as knowledge distillation (KD) from a bigger model -- its zero-shot out-of-domain utility improves at an even faster pace. Improved source domain learning also demonstrates superior out-of-domain generalization over three popular existing DG approaches that aim to limit overfitting. Our implementation of KD-based domain generalization is available via PrimeQA at: https://ibm.biz/domain-generalization-with-kd.
Assessment of Peripheral Fusion under the Correction of the Angle of Strabismus. Study Using New Four-Dot Test. (1997)

眼鏡を装用せずに日常視に近い状態で周辺融像の検査が可能なNEW4灯テスト(N4D)を使用して,斜視患者の潜在的両眼視機能を評価し,Worth-4灯テスト(W4D)および大型弱視鏡(SYNOPT)の周辺融像結果と比較検討した。プリズムによる眼位矯正後にN4DとW4Dで18名の斜視患者に対して周辺融像の検出率を比較すると,N4Dでは16名(88.9%)であったのに対してW4Dでは6名(33.3%)で統計学的に有為にN4Dで高い融像検出率であった。同様に,N4DとSYNOPTで26名の患者に対して周辺融像の検出率を比較すると,N4Dでは20名(76.9%)であったのに対してSYNOPTでは9名(34.6%)で,これは統計学的にN4Dで有意に高い融像検出率であった。眼位矯正後のN4D使用は,日常視に近い状態で斜視眼の潜在的な周辺融像の状態が簡単に評価でき,日常臨床においても有用であると考えられる。
An interactive eye‐tracking system for measuring radiologists' visual fixations in volumetric CT images: Implementation and initial eye‐tracking accuracy validation (2021)

An integrated eye-tracker system to assess reader eye movement and interactive viewing in relation to imaging targets demonstrated reasonable spatial accuracy for assessment of visual fixation. The head-free movement condition with audio biofeedback performed similarly to head-stabilized mode.
In vivo stimulatory effect of multi-component herbal remedy PADMA 28 on mitogen-induced proliferation of mice splenic lymphocytes and their chemokinetic activity (2013)

The results of our investigations suggest that PADMA 28 can stimulate cell-mediated immunity in mice and might be used for this purpose in the wide spectrum of doses.
Recording performances of COHOE's on dichromated gelatin, dichromated polymers and photoresists: a comparative study (1993)

peer reviewed
GaN Memory Operational at 300 °C (2022)

The most commonly used memory cells, namely a 32-bit <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\times10$ </tex-math></inline-formula> -bit read-only memory, a 1-bit 4-transistor static random-access memory, D latch, and D flip-flop (DFF), were demonstrated using high temperature (HT) GaN technology on a monolithically integrated GaN-on-Si platform and n-FET-only E/D-mode logic (E: enhancement, D: depletion). The memory cells exhibit stable operation at 300 °C. A maximum clock frequency of 36 MHz at 300 °C was estimated for the DFF using the measured setup time. To the best of the authors’ knowledge, the operational temperature of the reported prototypes represents the highest value for GaN memory, paving the way for the realization of robust mixed-signal systems operating at HT.