gebhart/patrepeval huggingface dataset:
Intramuscular Transplantation of Human Postnatal Myoblasts Generates Functional Donor-Derived Satellite Cells (2010)

Myogenic cell transplantation is an experimental approach for the treatment of myopathies. In this approach, transplanted cells need to fuse with pre-existing myofibers, form new myofibers, and generate new muscle precursor cells (MPCs). The last property was fully reported following myoblast transplantation in mice but remains poorly studied with human myoblasts. In this study, we provide evidence that the intramuscular transplantation of postnatal human myoblasts in immunodeficient mice generates donor-derived MPCs and specifically donor-derived satellite cells. In a first experiment, cells isolated from mouse muscles 1 month after the transplantation of human myoblasts proliferated in vitro as human myoblasts. These cells were retransplanted in mice and formed myofibers expressing human dystrophin. In a second experiment, we observed that inducing muscle regeneration 2 months following transplantation of human myoblasts led to myofiber regeneration by human-derived MPCs. In a third experiment, we detected by immunohistochemistry abundant human-derived satellite cells in mouse muscles 1 month after transplantation of postnatal human myoblasts. These human-derived satellite cells may correspond totally or partially to the human-derived MPCs evidenced in the first two experiments. Finally, we present evidence that donor-derived satellite cells may be produced in patients that received myoblast transplantation.
The effects of thin capping layers between quantum wells and barriers on the quantum efficiency enhancement in InGaN-based light emitting diodes (2013)

We discovered that adding H2 to the carrier gas in GaN barrier growth improved the light emitting diode (LED) peak quantum efficiency and shifted the efficiency maxima toward lower currents (∼20 mA). This implies that the Shockley–Read–Hall nonradiative process can be suppressed via the introduction of combination carrier gas (H2/N2) during barrier growth. Further, 1–2 nm thick Al-In-Ga-N alloys were adopted as capping layers to circumvent H2 etching effect during growth interruption. It was then revealed that quantum efficiency was effectively enhanced for LEDs employed with these thin large bandgap capping layers, particularly at low injection levels. Numerical simulation suggested that the improved quantum efficiency can be ascribed to the increased electron capture rate in the active region as well as enhanced electron and hole wavefunction overlap, which correlated well with experimental results.
Carbodiimide modification enhances activity of pig pancreatic phospholipase A2 (1994)

Pig phospholipase A2, pig iso-phospholipase A2 and bovine pancreatic phospholipase A2 were reacted in solution with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, in the presence of N-hydroxysulfosuccinimide, at pH 7. The influence of micellar protectants was analyzed. In the presence of n-hexadecylphosphocholine, the losses of activity in micellar diheptanoyl-lecithin were 80, 35, and 10% in bovine phospholipase A2, pig iso-phospholipase A2, and pig phospholipase A2, respectively. With 1-oleoylglycerophosphocholine, the bovine enzyme lost 40% activity, but the pig enzyme was activated sevenfold. The modified pig enzyme showed pre-micellar activation on monomeric diheptanoyl-lecithin, and either reduced or increased activities on mixed micelles of bile salt with egg phosphatidylcholine, depending on the composition of the micelles. This activation is consistent with previous protein-engineering studies of pig pancreatic phospholipase A2. In this study, we present new information concerning the specificity and interfacial recognition behaviour of this enzyme in relation to this activation.
Effect of Silver Nanoparticles and Antibiotics on Antibiotic Resistance Genes in Anaerobic Digestion (2013)

Water resource recovery facilities have been described as creating breeding ground conditions for the selection, transfer, and dissemination of antibiotic resistance genes (ARGs) among various bacteria. The objective of this study was to determine the effect of direct addition of antibiotic and silver nanoparticles (Ag NPs, or nanosilver) on the occurrence of ARGs in thermophilic anaerobic digesters. Test thermophilic digesters were amended with environmentally-relevant concentrations of Ag NP (0.01, 0.1, and 1.0 mg-Ag/L; corresponding to approximately 0.7, 7.0, and 70 mg-Ag/kg total solids) and sulfamethoxazole (SMX) that span susceptible to resistant classifications (1, 5, and 50 mg/L) as potential selection pressures for ARGs. Tetracycline (tet(O), tet(W)) and sulfonamide (sulI, sulII) ARGs and the integrase enzyme gene (intI1) associated with Class 1 integrons were measured in raw sludge, test thermophilic digesters, a control thermophilic digester, and a control mesophilic digester. There was no apparent effect of Ag NPs on thermophilic anaerobic digester performance. The maximum SMX addition (50 mg/L) resulted in accumulation of volatile fatty acids and low pH, alkalinity, and volatile solids reduction. There was no significant difference between ARG gene copy numbers (absolute or normalized to 16S rRNA genes) in amended thermophilic digesters and the control thermophilic digester. Antibiotic resistance gene copy numbers in digested sludge ranged from 10(3) to 10(6) copies per microL (approximately 8 x10(1) to 8 x 10(4) copies per microg) of sludge as result of a 1-log reduction of ARGs (2-log reduction for intI1). Quantities of the five ARGs in raw sludge ranged from 10(4) to 10(8) copies per microL (approximately 4 x 10(2) to 4 x 10(6) per microg) of sludge. Test and control thermophilic digesters (53 degrees C, 12-day solids retention time [SRT]) consistently reduced but did not eliminate levels of all analyzed genes. The mesophilic digester (37 degrees C, 20-day SRT) also reduced levels of sulI, sulII, and intI1 genes, but levels of tet(O) and tet(W) were the same or higher than in raw sludge. Antibiotic resistance gene reductions remained constant despite the application of selection pressures, which suggests that digester operating conditions are a strong governing factor of the bacterial community composition and thus the prevalence of ARGs.
Test-retest reliability of FreeSurfer-derived volume, area and cortical thickness from MPRAGE and MP2RAGE brain MRI images (2022)

Data collected on different scanners and head coils using MPRAGE and MP2RAGE are generally consistent for surface area and volume estimates. However, regional variability may constrain accuracy in some regions and cortical thickness measurements exhibit higher generalized variability.
Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms (2021)

Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms
Current detection circuit in multiple parallel connection circuit of high‐power semiconductor modules (2021)

Abstract We are developing current‐detection technology that directly measures the main current of a high‐power semiconductor module using the wiring inductance of the module. In a previous study, we proposed a circuit that detects current by integrating the voltage generated in the wiring inductance between the sense emitter and emitter terminals of the IGBT (Insulated Gate Bipolar Transistor) module. In this study, we developed a total current detection scheme for parallel‐connected modules. The basic principle of this scheme is that the total current can be obtained by the total of each voltage generated on the wiring inductance of each module. It was realized by using only one integrating circuit. A challenge for this study was avoiding reflection caused by impedance mismatch. We addressed this by adding a termination resistance with the same value as the characteristic impedance.
Estimate on CO 2 Emissions Reduction Effects Achieved by the Adoption of a Water Spray Humidification System to Clean Rooms ISSM Paper: ES-O-130 (2007)

We proposed water spray humidification in an indoor system for clean rooms used for the production of semiconduc- tors and FPDs, and calculated the energy-saving effect and CO2 emission reduction effect of this system. As a result of estimate on annual energy consumption by air conditioning at model semiconductor factory, this system can be reduced heating load of 76% and CO2 emission of 0.23 ton-CO2/Year per volume of outside air of 1 m 3 /min.
Comparison of fluorine-18-fluorodeoxyglucose and carbon-11-methionine PET in detection of malignant tumors. (1996)

PET using FDG and Met appear equally effective in detecting residual or recurrent malignant tumors although FDG uptakes were slightly higher than Met uptakes. Both showed a limited diagnostic sensitivity for small (< 1.5 cm) tumors.
Simulation of Morphology and Dynamics in Hydroxide-Conducting Polysulfones for Alkaline Batteries. (2023)

Abstract not provided.
Vibroseis simultaneous shooting using encoded sweeps: A field experiment (2017)

Simultaneous shooting for land seismic acquisition has been used very successfully in recent years to improve source sampling and acquisition efficiency. Most of the simultaneous shooting methodscurrently employed are applicable for surveys conducted in areas where very large receiver arrays can be used, and where there are no restrictions to using a large number of vibrators and how they move in the field. Here, we propose a vibroseis simultaneous shooting method for areas where the use of a very large receiver spread and free vibrator access is not possible. Presentation Date: Wednesday, September 27, 2017 Start Time: 10:10 AM Location: 371F Presentation Type: ORAL
A Limited Fixation, Olecranon Sparing Approach, for Management of Geriatric Intra-Articular Distal Humerus Fractures (2020)

A limited fixation technique based on achieving varus/valgus stability with columnar fixation, demonstrated equivalent outcomes in elderly patients with intra-articular distal humerus fractures when compared to intra-articular ORIF with an olecranon osteotomy.
Supplementary Figure 5 from Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus (2023)

&lt;p&gt;Model of mTOR activation and everolimus sensitivity caused by TSC2 loss.&lt;/p&gt;
3D-optimized SRAM Macro Design and Application to Memory-on-Logic 3D-IC at Advanced Nodes (2020)

We present local & global SRAM macro optimizations for 3nm FinFET and 2nm Nanosheet using Face-to-Face (F2F) and Wafer-to-Wafer (W2W) hybrid bonding at sub 1um pitch. Bonding pad parasitics are measured experimentally to calibrate RC models of the pad used to evaluate 3D-optimized memory macro delays. 3Doptimized macros are designed to reduce the macro external delay by ~50%. With customized SRAM BEOL, performance improvement of up to 70% for larger memories is observed compared with 2D macro. We also show that bit-cell tech-level optimizations have minor impact on the performance of large caches at advanced nodes due to high metal resistance in the macro global routing. Finally, at system-level we partition a L2 data memory (with 3D-optimized macro) from logic showing that the 3D implementation achieves a total of 33% performance gain with respect to a 2D implementation.
Information theoretic bounds on the throughput scaling of wireless relay networks (2005)

The throughput of wireless networks is known to scale poorly when the number of users grows. The rate at which an arbitrary pair of nodes can communicate must decrease to zero as the number of users tends to infinity, under various assumptions. One of them is the requirement that the network is fully connected: the computed rate must hold for any pair of nodes of the network. We show that this requirement can be responsible for the lack of throughput scalability. We consider a two-dimensional network of extending area with only one active source-destination pair at any given time, and all remaining nodes acting only as possible relays. Allowing an arbitrary small fraction of the nodes to be disconnected, we show that the per-node throughput remains constant as the network size increases. This result relies on percolation theory arguments and does not hold for one-dimensional networks, where a non-vanishing rate is impossible even if we allow an arbitrary large fraction of nodes to be disconnected. A converse bound is obtained using an ergodic property of shot noises. We show that communications occurring at a fixed nonzero rate imply a fraction of the nodes to be disconnected. Our results are of information theoretic flavor, as they hold without assumptions on the communication strategies employed by the network nodes.
ChemInform Abstract: Synthesis of 5‐Cyanoindazole and 1‐Methyl‐ and 1‐Aryl‐5‐cyanoindazoles. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Importance of Communication Between Producers and Consumers of Publicly Available Experimental Data (2005)

The application of mass spectrometry to discover new cancer biomarkers is in its infancy. Many of these new markers are low-abundance proteins that exist as fragments associated with carrier proteins. Although reproducibility is key to the use of mass spectrometry for ion fingerprint analysis, the scientific community has yet to establish a common platform or standardized operating procedures that are necessary for intra- and inter-laboratory comparison. In an effort to assist others who are perfecting mass spectrometry platforms for profiling, ongoing experimental data were posted for public consumption. An unintended consequence of unrestricted access to experimental data is the risk of inappropriate conclusions drawn and publicly disseminated that could have been avoided by communication between the producers and consumers of the data. Such disputes, however, should not divert us from the validation of this promising new approach.
Pilot-aided carrier frequency offset estimation for OFDM systems (2008)

The paper proposes novel carrier frequency offset estimation algorithm that exploits scattered pilot symbols used for channel estimation of OFDM systems. Carefully designed pilot symbols can be incorporated to form null subcarriers by trivial manipulation of the received OFDM signals so that null subcarrier based maximum likelihood CFO estimation method can be applied, whereas conventional maximum likelihood CFO estimation using pilot symbols jointly estimates CFO and channel impulse response iteratively which is impractical. Simulation results show satisfactory performance for frequency tracking stage. The paper also provides reduced order polynomial rooting method for simple and fast CFO estimation.
Variability Across Ten Production Lots of a Single Demineralized Bone Matrix Product (2010)

Assays for demineralized bone matrix-extracted BMP-2 and BMP-7 levels may be feasible and sufficient for predicting spinal fusion performance of individual production lots from the same demineralized bone matrix-based product.
Constructive and Destructive Processes During the 2018–2019 Eruption Episode at Shiveluch Volcano, Kamchatka, Studied From Satellite and Aerial Data (2021)

Dome-building volcanoes often develop by intrusion and extrusion, recurrent destabilization and sector collapses, and renewed volcanic growth inside the collapse embayment. However, details of the structural architecture affiliated with renewed volcanic activity and the influences of regional structures remain poorly understood. Here, we analyze the recent activity of Shiveluch volcano, Kamchatka Peninsula, characterized by repeated episodes of lava dome growth and destruction due to large explosions and gravity-driven collapses. We collect and process a multisensor dataset comprising high-resolution optical (aerial and tri-stereo Pleiades satellite), radar (TerraSAR-X and TanDEM-X satellites), and thermal (aerial and MODIS, Sentinel-2, and Landsat 8 satellites) data. We investigate the evolution of the 2018–2019 eruption episode and evaluate the morphological and structural changes that led to the August 29, 2019 explosive eruption and partial dome collapse. Our results show that a new massive lava lobe gradually extruded onto the SW flank of the dome, concurrent with magmatic intrusion into the eastern dome sector, adding 0.15 km 3 to the lava dome complex. As the amphitheater infilled, new eruption craters emerged along a SW-NE alignment close to the amphitheater rim. Then, the large August 29, 2019 explosive eruption occurred, followed by partial dome collapse, which was initially directed away from this SW-NE trend. The eruption and collapse removed 0.11 km 3 of the dome edifice and led to the formation of a new central SW-NE-elongated crater with dimensions of 430 m × 490 m, a collapse scar at the eastern part of the dome, and pyroclastic density currents that traveled ∼12 km downslope. This work sheds light on the structural architecture dominated by a SW-NE lineament and the complex interplay of volcano constructive and destructive processes. We develop a conceptual model emphasizing the relevance of structural trends, namely, 1) a SW-NE-oriented (possibly regional) structure and 2) the infilled amphitheater and its decollement surface, both of which are vital for understanding the directions of growth and collapse and for assessing the potential hazards at both Shiveluch and dome-building volcanoes elsewhere.
Sequential Convective Therapies (SCT): A Prospective Study on Feasibility, Safety, Adequacy and Tolerance of On-Line Hemofiltration and Hemodiafiltration in Sequence (2005)

Sequential dialysis techniques (i.e pure ultrafiltration followed by dialysis) have been used in the past, due to their capability to remove large volumes of fluids without inducing hemodynamic instability. The disadvantages of inadequate efficiency and lack of technology lead to the decline of such methods. Hemofiltration (HF) and hemodiafiltration (HDF) are recently being utilized in a greater proportion thanks to on-line fluid preparation systems. Each process (HF and HDF) has its own benefits in the removal of small, medium and high-molecular weight substances and in hemodynamic stability. Sequential convective therapies (SCT) such as hemofiltration-hemodiafiltration in sequence (HF-HDF) may combine the benefits and eliminate the disadvantages of each method and should be studied in order to explore their potential application in modern dialysis. Furthermore they can be easily applied nowadays, due to the development of new sophisticated dialysis machines. In order to evaluate the feasibility, safety, efficiency and tolerance of different SCT methods we studied 3 schedules: SCT1: 1h pre-dilution HF followed by 3h of postdilution HDF (in the HF mode we lost 25% of the total fluid that had to be removed). SCT2: 1h pre-dilution HF followed by 3h of post-dilution HDF (in the HF mode we lost 50% of the total fluid that had to be removed). SCT3: 2h pre-dilution HF followed by 2h of post-dilution HDF (in the HF mode we lost 50% of the total fluid that had to be removed). We studied 6 chronic hemodialysis patients using the same machine (AK200 ULTRA), with on-line fluid preparation system and the same type of dialyzer (Polyflux 210). SCT schedules were compared to on-line HF, on-line HDF and high flux dialysis performed with the same dialyzers. The treatments resulted safe, easy, feasible and well tolerated with an improved hemodynamic response to high volume convective therapies. Adequacy of treatment was satisfactory in all SCT schedules while middle molecular weight solute clearance and removal resulted higher in treatments with higher convective component. SCT might represent an interesting option for the future especially in patients with hemodynamic instability and requirements for interventions during treatment.
Integration of HIV-1 DNA Is Regulated by Interplay between Viral Rev and Cellular LEDGF/p75 Proteins (2009)

The present work describes a novel interaction between the human immunodeficiency virus type 1 (HIV-1) Rev protein and the cellular lens epithelium-derived growth factor p75 (LEDGF/p75) protein in vitro and in virus-infected cells. Here we show, for the first time, that formation of an Rev-LEDGF/p75 complex is a crucial step in regulating viral cDNA integration. Coimmunoprecipitation experiments at various times after virus infection revealed that, first, an integrase enzyme (IN)-LEDGF/p75 complex is formed, which is then replaced by a Rev-LEDGF/p75 and Rev-IN complexes. This was supported by in vitro experiments showing that Rev promotes dissociation of the IN-LEDGF/p75 complex. Combination of the viral IN and the cellular LEDGF/p75 is required for proper integration of the viral cDNA into the host chromosomal DNA. Our findings demonstrate that integration of HIV-1 cDNA is regulated by an interplay between viral Rev and the host-cell LEDGF/p75 proteins.
A Novel Polar Separation Medium for the Size Exclusion Chromatography of Small Molecules: Uniformly Sized, Porous Poly(vinylphenol-co-divinylbenzene) Beads (1997)

Abstract A novel separation medium based on uniform size beads of 4-hydroxystyrene-divinylbenzene can be used for both the size exclusion chromatography of small molecules and their separation by reversed-phase chromatography. The new 5 μm material is prepared by the controlled swelling of monodispersed polystyrene particles, that serve both as porogen and shape template, with a polymerization mixture consisting of the monomers and dibutylphthalate, followed by a suspension polymerization. Removal of the acetoxy groups by hydrolysis with aqueous base leads to the final poly(4-vinylphenol-co-divinylbenzene) monodispersed beads. Polymerization conditions that favor the formation of very small pores were developed to optimize the beads for the SEC separation of small molecules. The SEC calibration curve confirms that the optimized beads contain a large volume of pores suitable for the separation of solutes with a molecular weight of up to about 1000. The ability to separate alkylbenzenes according to their hydrodynamic sizes has been demonstrated using a column packed with this material. In addition, the phenol chemistry used in combination with a hydrophobic crosslinking monomer provides this separation medium with an unusual versatility that allows both reversed phase and normal phase chromatography to be run in the same column after a simple change of the mobile phase.
Electrically conductive thin-film color filters made of single-material indium-tin-oxide (2011)

Periodic multilayer thin-film color filters (CFs) entirely made of nano-porous indium-tin-oxide (ITO) with tunable refractive index are explored. The interference CFs are electrically conductive and transmit light in the pass-band spectral region without absorbing light outside of the pass-band region. The transfer matrix method, implemented in conjunction with a genetic algorithm optimization method, is used to design the optimal thickness and refractive index of layers for red, green, and blue (RGB) filters. RGB filters with 2 pairs (4 layers) are experimentally demonstrated by using a porosity-controlling deposition technique for a single material—ITO. A maximum transmittance of 95.2% and a minimum transmittance of 26.2% are demonstrated for the four pairs of a red filter structure. A light recycling structure using these RGB filters is proposed to reduce the optical loss occurring in conventional liquid-crystal display systems.