gebhart/patrepeval huggingface dataset:
A Receptor-Targeted Near-Infrared Fluorescence Probe for In Vivo Tumor Imaging (2002)

Shedding light on tumors: An optical probe that consists of a near-infrared fluorochrome and folic acid was designed for in vivo tumor detection. The probe binds strongly to tumor-associated folate receptors both in vitro and in vivo. After intravenous injection of the probe, an intense fluorescence signal was observed in a mouse ovarian tumor model (see picture). Modification of fluorochromes with small molecules may thus be used in many biological and medicinal applications.
Book reviews (1985)

Can psychology help in Rehabilitation?: Recovery and Management of Neuropsychological Impairments. E. Miller. J. Wiley & Sons, 1984. 179 pp., 9 illustrations. £ 12.50. ISBN 0-471-10532-5.A novel approach to education: Multiple Choice Questions in Rheumatology. P.J. Rooney, W. F. Kean, N Bellamy and W.W. Buchanan. Butterworths, London, 191 pages, 25 illustrations, £6.95. ISBN 0-407-002391.
Modeling of miRNA and Drug Action in the EGFR Signaling Pathway (2012)

MicroRNAs have gained significant interest due to their widespread occurrence and diverse functions as regulatory molecules, which are essential for cell division, growth, development and apoptosis in eukaryotes. The epidermal growth factor receptor (EGFR) signaling pathway is one of the best investigated cellular signaling pathways regulating important cellular processes and its deregulation is associated with severe diseases, such as cancer. In this study, we introduce a systems biological model of the EGFR signaling pathway integrating validated miRNA-target information according to diverse studies, in order to demonstrate essential roles of miRNA within this pathway. The model consists of 1241 reactions and contains 241 miRNAs. We analyze the impact of 100 specific miRNA inhibitors (anit-miRNAs) on this pathway and propose that the embedded miRNA-network can help to identify new drug targets of the EGFR signaling pathway and thereby support the development of new therapeutic strategies against cancer.
Dyeing Para-Aramid Textiles Pretreated with Soybean Oil and Nonthermal Plasma Using Cationic Dye (2021)

The increasing use of functional aramids in a wide array of applications and the inert nature of aramids against conventional dye and print methods requires developing new dyeing methods. This study aims to use environmentally friendly method with a cationic dye as an alternative for dyeing para-aramid fabrics. Experiments used a multi-factorial design with functions of pretreatment, dye solvent (water and/or glycerol) and auxiliary chemical additives (swelling agent and surfactant) and a sequential experimentation methodology. The most effective dyeing procedures involved the following steps: (i) pretreatments of the fabrics with soybean oil and nonthermal plasma (NTP), (ii) using water at T = 100 °C as the dye solvent, and (iii) omitting other chemical additives. With a commercial cationic dye, these conditions achieved a color strength in K/S value of 2.28, compared to ~1 for untreated samples. FTIR analysis revealed that a functional network formed on the fibers and yarns of the fabrics by chemical reactions of excited plasma species with double bonds in the soybean oil molecules was responsible for significantly improving the color strength. These results extend the potential uses of a renewable material (soybean oil) and an environmentally friendly technology (NTP) to improve the dyeing of para-aramid textiles and reduce the use of harsh dye chemicals.
Enhancement of spin-charge conversion efficiency for Co3Sn2S2 across transition from paramagnetic to ferromagnetic phase (2023)

${\mathrm{Co}}_{3}{\mathrm{Sn}}_{2}{\mathrm{S}}_{2}$ (CSS) is one of the shandite compounds and becomes a magnetic Weyl semimetal candidate below the ferromagnetic phase transition temperature (${T}_{\mathrm{C}}$). In this paper, we investigate the temperature ($T$) dependence of conversion between charge current and spin current for the CSS thin film by measuring the spin-torque ferromagnetic resonance (ST-FMR) for the trilayer consisting of CSS/Cu/CoFeB. Above ${T}_{\mathrm{C}}\ensuremath{\sim}170$ K, the CSS/Cu/CoFeB trilayer exhibits the clear ST-FMR signal coming from the spin Hall effect in the paramagnetic CSS and the anisotropic magnetoresistance (AMR) of CoFeB. Below ${T}_{\mathrm{C}}$, on the other hand, it is found that the ST-FMR signal involves the dc voltages $({V}_{\mathrm{dc}})$ not only through the AMR but also through the giant magnetoresistance (GMR). Thus, the resistance changes coming from both AMR and GMR should be taken into account to correctly understand the characteristic field angular dependence of ${V}_{\mathrm{dc}}$. The spin Hall torque generated from the ferromagnetic CSS, which possesses the same symmetry as that for spin Hall effect, dominantly acts on the magnetization of CoFeB. A definite increase in the spin-charge conversion efficiency is observed at $T&lt;{T}_{\mathrm{C}}$, indicating that the phase transition to the ferromagnetic CSS promotes the highly efficient spin-charge conversion. In addition, our theoretical calculation shows the increase in spin Hall conductivity with the emergence of magnetic moment at $T&lt;{T}_{\mathrm{C}}$, which is consistent with the experimental observation.
Multicell cooperation for LTE-advanced heterogeneous network scenarios (2013)

In this article we present two promising practical use cases for simple multicell cooperation for LTE-Advanced heterogeneous network scenarios with macro and small cells. For co-channel deployment cases, we recommend the use of enhanced interference coordination, or eICIC, to mitigate cross-tier interference and ensure sufficient offload of users from macro to small cells. It is shown how the eICIC benefit is maximized by using a distributed inter-base station control framework for dynamic adjustment of essential parameters. Second, for scenarios where macro and small cells are deployed at different carriers an efficient use of the fragmented spectrum can be achieved by using collaborative inter-site carrier aggregation. In addition to distributed coordination/collaboration between base station nodes, the importance of explicit terminal assistance is highlighted. Comprehensive system-level simulation results illustrate the performance benefits of the presented techniques.
Improving Energy Efficiency in FPGA Through Judicious Mapping of Computation to Embedded Memory Blocks (2013)

Field-programmable gate arrays (FPGAs) are being increasingly used as a preferred prototyping and accelerator platform for diverse application domains, such as digital signal processing (DSP), security, and real-time multimedia processing. However, mapping of these applications to FPGA typically suffers from poor energy efficiency because of high energy overhead of programmable interconnects (PI) in FPGA devices. This paper presents an energy-efficient heterogenous application mapping framework in FPGA, where the conventional application mappings to logic and DSP blocks (for DSP-enhanced FPGA devices) are combined with judicious mapping of specific computations to embedded memory blocks. A complete mapping methodology including functional decomposition, fusion, and optimal packing of operations is proposed and efficiently used to reduce the large energy overhead of PIs. Effectiveness of the proposed methodology is verified for a set of common applications using a commercial FPGA system. Experimental results show that the proposed heterogenous mapping approach achieves significant energy improvement for different input bit-widths (e.g., more than 35% of energy savings with 8 bit or smaller bit inputs compared to the corresponding mapping in configurable logic blocks). For further reduction of energy, we propose an energy/accuracy tradeoff approach, where the input operand bit-width is dynamically truncated to reduce memory area and energy at the expense of modest degradation in output-accuracy. We show that using a preferential truncation method, up to 88.6% energy savings can be achieved in a 32-tap finite impulse response filter with modest impact on the filter performance.
Analyzing AR Viewing Experience through Analytics Heat Maps for Augmented Content (2017)

Analytics is a well-known form of capturing information about the user behavior of an application. Augmented reality applications deal with specific data such as the camera pose, not being supported by popular analytics frameworks. To fill such gap, this work proposes an analytics framework solution for augmented reality applications. It supports both marker-based and markerless augmented reality scenarios, collecting data related to camera pose and time spent by the user on each position. Besides the multiplatform capture tool, the framework provides a data analysis visualization tool capable of highlighting the most visited 3D positions, users main areas of interest over the marker plane, the 3D path performed by the camera and also a recovery of the content viewed by the user based on the collected camera pose information.
NOAA holistic climate and earth system model strategy. Phase I, Current state. (2015)

This report describes Phase I of a two-phase study proposed and organized by the NOAA Climate Program Office (CPO) in early 2014 for the development of a NOAA Holistic Climate and Earth System Modeling Strategy. Defining NOAA’s strategy for global climate and earth system modeling for research and operations allows NOAA’s investments in this area to be optimally targeted and leveraged, facilitates linkages with broader environmental modeling efforts within NOAA and outside of NOAA, and enhances NOAA’s participation in the interagency Earth System Prediction Capability initiative. A strategy also helps to identify gaps and opportunities to advance NOAA’s global climate and earth system models and identify resources and synergies needed to maximize the return on those investments. In addition, the 2012 National Research Council report on “A National Strategy for Advancing Climate Modeling” prompts a careful reconsideration of NOAA’s strategy in this area. Phase I defines the current state of, and plans for, NOAA’s global climate and earth system models, developed at the Geophysical Fluid Dynamics Laboratory, the Earth System Research Laboratory, and the National Centers for Environmental Prediction Environmental Modeling Center. This report lays the necessary groundwork for the planned second phase of the CPO proposed study whose ultimate goal is to present potential future model development pathways contributing to the definition of a holistic strategy to advance NOAA global climate and earth system models for research and operations.
Refractive Index Tomography by Digital Holographic Microscopy (2008)

Full 3D Refractive Index (RI) tomography appears as a challenging perspective in the observation of microscopic 3D objects, biological cells in particular. Recent developments in Digital Holographic Microscopy (DHM) have permitted to achieve accurate RI 3D images.
Effects of top electrode material in hafnium-oxide-based memristive systems on highly-doped Si (2020)

This work provides useful insights into the development of HfO<sub>2</sub>-based memristive systems with a p-type silicon bottom electrode that are compatible with the complementary metal-oxide-semiconductor technology. The results obtained reveal the importance of the top electrode selection to achieve unique device characteristics. The Ag/HfO<sub>2</sub>/Si devices have exhibited a larger memory window and self-compliance characteristics. On the other hand, the Au/HfO<sub>2</sub>/Si devices have displayed substantial cycle-to-cycle variation in the ON-state conductance. These device characteristics can be used as an indicator for the design of resistive-switching devices in various scenes such as, memory, security, and sensing. The current-voltage (I-V) characteristics of Ag/HfO<sub>2</sub>/Si and Au/HfO<sub>2</sub>/Si devices under positive and negative bias conditions have provided valuable information on the ON and OFF states of the devices and the underlying resistive switching mechanisms. Repeatable, low-power, and forming-free bipolar resistive switching is obtained with both device structures, with the Au/HfO<sub>2</sub>/Si devices displaying a poorer device-to-device reproducibility. Furthermore, the Au/HfO<sub>2</sub>/Si devices have exhibited N-type negative differential resistance (NDR), suggesting Joule-heating activated migration of oxygen vacancies to be responsible for the SET process in the unstable unipolar mode.
Heterodyne-detected and ultrafast time-resolved second-harmonic generation for sensitive measurements of charge transfer (2014)

In organic photovoltaics many key ultrafast processes occur at the interface between electron donor and acceptor molecules. Traditional ultrafast spectroscopies, such as pump-probe or time-resolved fluorescence, are not ideal for studying the interface because most of their signal is from the bulk material. Time-resolved second-harmonic generation (TRSHG) spectroscopy solves this problem by only generating signal from the interface. We demonstrate an optically heterodyned TRSHG to reduce the impact of stray light, enhance sensitivity, and detect the full complex signal field.
The Key to Successfully Applying Today's Lost Circulation Solutions (2005)

Abstract Though strengthening boreholes with particulate treated mud has achieved tremendous success in the past year, the theory behind the process still has not been widely accepted. Rock mechanics analysis and laboratory data review are performed in this paper to illustrate deepened understanding on some key points that are controversial. Algorithms have been developed and demonstrated for obtaining critical parameters in designing such jobs for improving hoop stress, by which a wellbore can be strengthened while drilling. Discussion of mechanisms and case histories has led to the development of systems that are designed to improve wellbore-pressure containment (WPC) by improving least principal stress. These systems are designed to function independent of formation permeability, unlike high fluid-loss and high solid-content squeeze pills. This method is normally applied when long fractures exist and when lost circulation has occurred. Since the first approach is proactive and the latter remedial or corrective, combining the two approaches can create synergy for borehole strengthening. A computer-aided design (CAD) process is also demonstrated for better use of available information in designing a deformable, viscous, and cohesive (DVC) system.
Both SH2 Domains Are Involved in Interaction of SHP-1 with the Epidermal Growth Factor Receptor but Cannot Confer Receptor-directed Activity to SHP-1/SHP-2 Chimera (1997)

The previously demonstrated functional and physical interaction of the SH2 domain protein-tyrosine phosphatase SHP-1 with the epidermal growth factor (EGF) receptor (Tomic, S., Greiser, U., Lammers, R., Kharitonenkov, A., Imyanitov, E., Ullrich, A., and Böhmer, F. D. (1995) J. Biol. Chem. 270, 21277-21284) was investigated with respect to the involved structural elements of SHP-1. Various mutants of SHP-1 were transiently expressed in 293 or COS-7 cells and analyzed for their capacity to associate with immobilized autophosphorylated EGF receptor in vitro and to dephosphorylate coexpressed EGF receptor in intact cells. Inactivating point mutation of the C-terminal SH2 domain reduced the association weakly, point mutation of the N-terminal SH2 domain reduced association strongly and the respective double mutation abolished association totally. The capacity of SHP-1 to dephosphorylate coexpressed EGF receptor was impaired by all point mutations. Truncation of the N-terminal or of both SH2 domains strongly reduced or abolished association, respectively, but the truncated SHP-1 derivatives still dephosphorylated coexpressed EGF receptor effectively. Various chimeric protein-tyrosine phosphatases constructed from SHP-1 and the closely homologous SHP-2 dephosphorylated the EGF receptor when they contained the catalytic domain of SHP-1. As native SHP-2, the chimera lacked activity toward the receptor when they contained the catalytic domain of SHP-2, despite their capacity to associate with the receptor and to dephosphorylate an artificial phosphopeptide. We conclude that the differential interaction of SHP-1 and SHP-2 with the EGF receptor is due to the specificity of the respective catalytic domains rather than to the specificity of the SH2 domains. Functional interaction of native SHP-1 with the EGF receptor requires association mediated by both SH2 domains.
Experimental Optical Multiplexing of Two 20-Gbit/s QPSK Data Channels from Different Wavelengths onto a Single 40-Gbit/s Star 16-QAM using Fiber Nonlinearities (2011)

We experimentally demonstrate optical multiplexing of two 20 Gbit/s QPSK channels at different wavelengths onto a single 40 Gbit/s star 16 QAM channel with tunable ring ratio using cascaded fiber based nonlinear stages. The impact of QPSK channel spacing is also investigated. BER measurements confirm the effectiveness of the proposed scheme.
Some results of the action of warm waters from thermal stations on the emissaries (1973)

Some aspects of thermal pollution studies developed in Romania are exemplified with data concerning the Jiu River and the Siut-Ghiol Lake. Research has shown that the warm water discharged into these waters has a fairly small influence on the physical-chemical and biological characteristics of their waters. (PCS)
Automatic generation of efficient accelerators for reconfigurable hardware (2016)

Acceleration in the form of customized datapaths offer large performance and energy improvements over general purpose processors. Reconfigurable fabrics such as FPGAs are gaining popularity for use in implementing application-specific accelerators, thereby increasing the importance of having good high-level FPGA design tools. However, current tools for targeting FPGAs offer inadequate support for high-level programming, resource estimation, and rapid and automatic design space exploration. We describe a design framework that addresses these challenges. We introduce a new representation of hardware using parameterized templates that captures locality and parallelism information at multiple levels of nesting. This representation is designed to be automatically generated from high-level languages based on parallel patterns. We describe a hybrid area estimation technique which uses template-level models and design-level artificial neural networks to account for effects from hardware place-and-route tools, including routing overheads, register and block RAM duplication, and LUT packing. Our runtime estimation accounts for off-chip memory accesses. We use our estimation capabilities to rapidly explore a large space of designs across tile sizes, parallelization factors, and optional coarse-grained pipelining, all at multiple loop levels. We show that estimates average 4.8% error for logic resources, 6.1% error for runtimes, and are 279 to 6533 times faster than a commercial high-level synthesis tool. We compare the best-performing designs to optimized CPU code running on a server-grade 6 core processor and show speedups of up to 16.7×.
Macromol. Biosci. 1/2013 (2013)

Back Cover: Biocides obtained from the acid-mediated partial hydrolysis of poly(2-oxazoline)s show excellent antimicrobial activity when added in low quantities to polypropylene during thermoforming processes: bacteria and fungi are destroyed upon mere contact with the compounds' surfaces. Further details can be found in the article by A. M. Kelly, V. Kaltenhauser, I. Mühlbacher, K. Rametsteiner, H. Kren, C. Slugovc, F. Stelzer, and F. Wiesbrock* on page 116.
Sociodemographic risk factors for hepatitis C virus infection in a prospective cohort study of 257 persons in Canada who inject drugs (2019)

In this prospective study, differences in age, timing of HCV testing and risk behaviours were found between anti-HCV-positive and anti-HCV-negative groups.
Aligned Carbon Nanotube Reinforcement of Aerospace Carbon Fiber Composites: Substructural Strength Evaluation for Aerostructure Applications (2012)

https://www.aiaa.org/ProceedingsDetail.aspx?id=5776
Stereocontrolled synthesis of C2-symmetric and pseudo-C2-symmetric diamino alcohols and diols for use in HIV protease inhibitors (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereocontrolled synthesis of C2-symmetric and pseudo-C2-symmetric diamino alcohols and diols for use in HIV protease inhibitorsDale J. Kempf, Thomas J. Sowin, Elizabeth M. Doherty, Steven M. Hannick, LynnMarie Codavoci, Rodger F. Henry, Brian E. Green, Stephen G. Spanton, and Daniel W. NorbeckCite this: J. Org. Chem. 1992, 57, 21, 5692–5700Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/jo00047a023https://doi.org/10.1021/jo00047a023research-articleACS PublicationsRequest reuse permissionsArticle Views476Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Lysolecithins as endothelium-dependent vascular smooth muscle relaxants that differ from endothelium-derived relaxing factor (nitric oxide) (1988)

The effects of lysolecithin (lysophosphatidylcholine) derived from egg yolk as well as of synthetic lysolecithins with different aliphatic chain lengths on tension development of rabbit aortic strips were investigated. Lysolecithins caused slowly progressing, dose-dependent relaxation that was inhibited by hemoglobin, methylene blue, and nordihydroguiaretic acid. Indomethacin caused no inhibition of relaxation. The degree of relaxation was endothelium-dependent and appeared to be related to the activation of guanylate cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2]. Superoxide dismutase failed to influence relaxation. Lysolecithins with the longest aliphatic chain were the most potent relaxants of aortic strips. The experiments suggest a role of lysolecithins through their weak detergent action on membrane dynamics of endothelial cells, resulting in the production of cyclic GMP and the relaxation of arterial smooth muscle. Lysolecithins differ in several respects from endothelium-derived relaxing factor. Endothelium-derived relaxing factor is an unstable humoral substance released from endothelium and is identical to nitric oxide, itself a labile substance causing vascular relaxation and cyclic GMP accumulation. Lysolecithins may represent a different type of endothelium-dependent muscle relaxant.