gebhart/patrepeval huggingface dataset:
Converter with phase-offset switching (2023)

Various examples are directed to electrical converters and systems for operating the same. An electrical converter may comprise a first converter module configured to receive a first direct current (DC) input and provide a first output. The first converter module may comprise a first switch modulated according to a first switch control signal. A second converter module may be configured to receive a second DC input and provide a second output. The second converter module may be connected in series with the first converter module. The second converter module may comprise a second switch modulated according to a second switch control signal. A phase of the first switch control signal may be offset from a phase of the second switch control signal by a first phase offset.
Investigation of new chalcogenide materials to improve the PCM performance (2011)

International audience
Nuclear morphometric features of epithelial cells lining keratocysts. (2003)

Increased cell density, a more ovoid nuclear shape and more variation in the size of basal layer cell nuclei in keratocysts were helpful in differentiating these lesions from other odontogenic cysts.
Stable Bulky Particles Formed by TS‐1 Zeolite Nanocrystals in the Presence of H2O2 (2010)

Abstract Bulky particles of TS‐1 zeolite (larger than 20 μm) are successfully collected by simple filtration after crystallization of TS‐1 zeolite in the presence of H 2 O 2 . Bulky TS‐1 (B‐TS‐1) has good stability under both ultrasonic conditions and in recycling of the catalyst. Nitrogen isotherms show that B‐TS‐1 has a larger mesopore volume (0.55 cm 3 g −1 ) than conventional TS‐1 nanocrystals (N‐TS‐1; less than 300 nm) obtained from high‐speed centrifugation (0.28 cm 3 g −1 ). In catalytic hydroxylation of phenol with H 2 O 2 , both fresh (25 %) and recycled B‐TS‐1 (24 %) show similar high activities to N‐TS‐1 (28 %). B‐TS‐1 was further characterized by X‐ray diffraction, scanning electron microscopy, transmission electron microscopy, UV/Vis spectroscopy, and other techniques. The results suggest that bulky particles of B‐TS‐1 were formed by strong interactions of the nanocrystals with each other in the synthesis of TS‐1 zeolite. Such unique structural features might be responsible for the high stability of the bulky particles, large mesopore volume, and high catalytic activities in phenol hydroxylation, as well as the collection of B‐TS‐1 from a simple filtration route.
Temperature-dependent characteristics and single-mode performance of AlGaInP-based 670-690-nm vertical-cavity surface-emitting lasers (1995)

We report on temperature dependent characteristics and single mode performance of one-wave cavity, planar implanted, AlGaInP-based vertical-cavity surface emitting lasers. By optimizing the overlap between the gain peak and the cavity mode of the structure, we demonstrate record device performance, including 8.2 mW maximum output power and 11% power conversion efficiency for multimode operation and 1.9 mW and 9.6% power conversion efficiency for single mode operation at 687 nm. Improved performance at elevated temperatures is also achieved, with 1.5 mW output power demonstrated at 50/spl deg/C from a 15-μm-diameter device.
Mid-Infrared Opto-nanofluidics for on-Chip Chemical Sensing (2014)

A mid-infrared (mid-IR) label-free chemical sensor was developed using opto-nanofluidics consisting of a Si-liquid-Si slot-structure. A broadband mid-IR lightwave can be strongly confined within a nanofluidic capillary by utilizing the large refractive index contrast (Δn ~ 2) between the liquid core waveguide and the Si cladding. Through an optical-field enhancement together with a direct interaction between the probe light and the analyte, the sensitivity for chemical detection is increased by 50 times when compared to evanescent-wave sensing. This spectral characterization distinguished several common organic liquids (e.g., n-bromohexane, toluene, isopropanol) accurately, and could determine the ratio of chemical species (e.g., acetonitrile and ethanol) at low concentration (&lt; 5 μL/mL) in a mixture through spectral scanning over their characteristic mid-IR absorption peaks. The combination of CMOS-compatible planar mid-IR microphotonics, and a high-throughput nanofluidic sensor system, provides a unique platform for chemical detection.
Restriction of food intake by PPP1R17-expressing neurons in the DMH (2021)

Leptin-deficient ob/ob mice eat voraciously, and their food intake is markedly reduced by leptin treatment. In order to identify potentially novel sites of leptin action, we used PhosphoTRAP to molecularly profile leptin-responsive neurons in the hypothalamus and brainstem. In addition to identifying several known leptin responsive populations, we found that neurons in the dorsomedial hypothalamus (DMH) of ob/ob mice expressing protein phosphatase 1 regulatory subunit 17 (PPP1R17) constitutively express cFos and that this is suppressed by leptin treatment. Because ob mice are hyperphagic, we hypothesized that activating PPP1R17 neurons would increase food intake. However, chemogenetic activation of PPP1R17 neurons decreased food intake and body weight of ob/ob mice while inhibition of PPP1R17 neurons increased them. Similarly, in a scheduled feeding protocol that elicits increased consumption, mice also ate more when PPP1R17 neurons were inhibited and ate less when they were activated. Finally, we found that pair-feeding of ob mice reduced cFos expression to a similar extent as leptin and that reducing the amount of food available during scheduled feeding in DMH<sup>Ppp1r17</sup> neurons also decreased cFos in DMH<sup>Ppp1r17</sup> neurons. Finally, these neurons do not express the leptin receptor, suggesting that the effect of leptin on these neurons is indirect and secondary to reduced food intake. In aggregate, these results show that PPP1R17 neurons in the DMH are activated by increased food intake and in turn restrict intake to limit overconsumption, suggesting that they function to constrain binges of eating.
Optimally designed narrowband guided-mode resonance reflectance filters for mid-infrared spectroscopy (2011)

An alternative to the well-established Fourier transform infrared (FT-IR) spectrometry, termed discrete frequency infrared (DFIR) spectrometry, has recently been proposed. This approach uses narrowband mid-infrared reflectance filters based on guided-mode resonance (GMR) in waveguide gratings, but filters designed and fabricated have not attained the spectral selectivity (≤ 32 cm(-1)) commonly employed for measurements of condensed matter using FT-IR spectroscopy. With the incorporation of dispersion and optical absorption of materials, we present here optimal design of double-layer surface-relief silicon nitride-based GMR filters in the mid-IR for various narrow bandwidths below 32 cm(-1). Both shift of the filter resonance wavelengths arising from the dispersion effect and reduction of peak reflection efficiency and electric field enhancement due to the absorption effect show that the optical characteristics of materials must be taken into consideration rigorously for accurate design of narrowband GMR filters. By incorporating considerations for background reflections, the optimally designed GMR filters can have bandwidth narrower than the designed filter by the antireflection equivalence method based on the same index modulation magnitude, without sacrificing low sideband reflections near resonance. The reported work will enable use of GMR filters-based instrumentation for common measurements of condensed matter, including tissues and polymer samples.
Injection Mold Design Engineering (2007)

You have accessInjection Mold Design EngineeringAug 2007Injection Mold Design EngineeringDavid O. KazmerDavid O. Kazmerhttps://doi.org/10.3139/9783446434196.fmSectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF ShareFacebookTwitterEmailLinkedIn next chapter FiguresReferencesRelatedDetails 2007Pages: I-XXPrint ISBN: 978-3-446-41266-8eISBN: 978-3-446-43419-6 Copyright & Permissions© 2007 Carl Hanser Verlag GmbH & Co. KGPDF DownloadLoading ...
Editorial: increasing burden of nonalcoholic fatty liver disease—a call to action. Authors' reply (2020)

LINKED CONTENT This article is linked to Estes et al and Chuah and Chan papers. To view these articles, visit https://doi.org/10.1111/apt.15673 and https://doi.org/10.1111/apt.15700 .
Electrospraying, spray drying and related techniques for production and formulation of drug nanoparticles (2010)

The most important advantage of these techniques as compared with many other particle formation techniques is that the production of dried powders is possible without any extra drying step.
Passive and hybrid modelocking of a grating-coupled surface-emitting laser (GCSEL) (2005)

We report the first passive and hybrid modelocking of a grating-coupled surface-emitting laser (GCSEL), exploiting the unpumped grating section of the GCSEL as a saturable absorber to generate short pulses, is demonstrated. Pulsewidths 2.8 psec with 1.1 nm bandwidth at 980 nm are obtained.
Molybdenum oxide structure on silica-supported catalysts studied by Raman spectroscopy and EXAFS (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolybdenum oxide structure on silica-supported catalysts studied by Raman spectroscopy and EXAFSNoriyoshi Kakuta, Kazuyuki Tohji, and Yasuo UdagawaCite this: J. Phys. Chem. 1988, 92, 9, 2583–2587Publication Date (Print):May 1, 1988Publication History Published online1 May 2002Published inissue 1 May 1988https://pubs.acs.org/doi/10.1021/j100320a037https://doi.org/10.1021/j100320a037research-articleACS PublicationsRequest reuse permissionsArticle Views286Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Plenoptic system response and image formation (2013)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. A. Shroff and K. Berkner, "Plenoptic system response and image formation," in Imaging and Applied Optics, OSA Technical Digest (online) (Optica Publishing Group, 2013), paper JW3B.1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Platinum nanoparticles/graphene composite catalyst as a novel composite counter electrode for high performance dye-sensitized solar cells (2011)

We herein describe our use of a water–ethylene method to prepare a composite material consisting of platinum nanoparticles and graphene. Results obtained using XPS and XRD show that the degree of reduction of graphene was increased by the incorporation of Pt, and in addition, the increased concentration of defects was confirmed by the D/G ratio of the Raman spectra obtained. In comparison with Pt films, results obtained using CV and EIS showed that the electrocatalytic ability of the composite material was greater, and afforded a higher charge transfer rate, an improved exchange current density, and a decreased internal resistance. SEM images showed that the morphology of PtNP/GR counter electrodes is characterized by a smooth surface, however, resulting in a lower resistance to diffusion, thereby improving the total redox reaction rate that occurs at the counter electrode. PtNP/GR electrodes have a number of advantages over other electrodes that consist solely of graphene or Pt films, including a high rate of charge transfer, a low internal resistance, and a low resistance to diffusion. In our study, we showed that DSSCs that incorporate platinum-grafted graphene had a conversion efficiency of 6.35%, which is 20% higher than that of devices with platinized FTO.
In Silico Identification and Clinical Validation of a Novel Long Non-Coding RNA/mRNA/miRNA Molecular Network for Potential Biomarkers for Discriminating SARS CoV-2 Infection Severity (2021)

(1) Background: The coronavirus (COVID-19) pandemic is still a major global health problem, despite the development of several vaccines and diagnostic assays. Moreover, the broad symptoms, from none to severe pneumonia, and the various responses to vaccines and the assays, make infection control challenging. Therefore, there is an urgent need to develop non-invasive biomarkers to quickly determine the infection severity. Circulating RNAs have been proven to be potential biomarkers for a variety of diseases, including infectious ones. This study aimed to develop a genetic network related to cytokines, with clinical validation for early infection severity prediction. (2) Methods: Extensive analyses of in silico data have established a novel IL11RA molecular network (IL11RNA mRNA, LncRNAs RP11-773H22.4 and hsa-miR-4257). We used different databases to confirm its validity. The differential expression within the retrieved network was clinically validated using quantitative RT-PCR, along with routine assessment diagnostic markers (CRP, LDH, D-dimmer, procalcitonin, Ferritin), in100 infected subjects (mild and severe cases) and 100 healthy volunteers. (3) Results: IL11RNA mRNA and LncRNA RP11-773H22.4, and the IL11RA protein, were significantly upregulated, and there was concomitant downregulation of hsa-miR-4257, in infected patients, compared to the healthy controls, in concordance with the infection severity. (4) Conclusion: The in-silico data and clinical validation led to the identification of a potential RNA/protein signature network for novel predictive biomarkers, which is in agreement with ferritin and procalcitonin for determination of COVID-19 severity.
Chemical Compatibility between Silver Electrodes and Low‐Firing Binary‐Oxide Compounds: Conceptual Study (2000)

The chemical compatibility of silver electrodes and low‐firing ceramics has been considered, in terms of the existence of a tie line between silver (and/or Ag 2 O) and the binary oxide compound in the corresponding ternary phase diagram. The probability of the existence of the tie line is related to the conditions in the subordinated silver‐based isothermal binary systems. Greater probabilities have been calculated for the systems with fewer silver‐based binary compounds. Based on the concepts that have been developed, several silver‐based isothermal binary systems have been investigated to identify the oxides suitable for the development of low‐temperature cofired ceramics. The developed concept has been tested by investigating the phase relations in the Bi 2 O 3 –Nb 2 O 5 and Bi 2 O 3 –V 2 O 5 ternary systems with silver. X‐ray and microstructural investigations of bismuth niobates and bismuth vanadates reveal that, as a result of the inertness of Bi 2 O 3 and the reactivity of Nb 2 O 5 and V 2 O 5 toward silver, compounds that are rich in niobium or vanadium react with silver to form ternary Nb/V‐Bi‐Ag oxide compounds, whereas for compounds that are rich in bismuth, tie lines to silver and Ag 2 O do exist.
IL-2 and IL-7 differentially induce CD4-CD8- alpha beta TCR+NK1.1+ large granular lymphocytes and IL-4-producing cells from CD4-CD8- alpha beta TCR+NK1.1- cells: implications for the regulation of Th1- and Th2- type responses (1997)

Effector functions of CD4-CD8- double negative (DN) alpha beta TCR+ cells were examined. Among mouse DN alpha beta TCR+ thymocytes, NK1.1+ cells expressing a canonical V alpha 14/J alpha 281 TCR but not NK1.1- cells produce IL-4 upon TCR cross-linking and IFN-gamma upon cross-linking of NK1.1 as well as TCR. Production of IL-4 but not IFN-gamma from DN alpha beta TCR+NK1.1+ cells was markedly suppressed by IL-2. Whereas V alpha 14/J alpha 281 TCR+ cells express NK1.1+, these cells are not the precursor of DN alpha beta TCR+NK1.1+CD16+B220+ large granular lymphocytes (LGL). IL-2 induces rapid proliferation and generation of NK1.1+ LGL from DN alpha beta TCR+NK1.1- but not from DN alpha beta TCR+NK1.1+ cells. LGL cells exhibit NK activity and produce IFN-gamma but not IL-4 upon cross-linking of surface TCR or NK1.1 molecules. In contrast to IL-2, IL-7 does not induce LGL cells or NK activity from DN alpha beta TCR+NK1.1- cells but induces the ability to produce high levels of IL-4 upon TCR cross-linking. Our results show that DN alpha beta TCR+ T cells have several distinct subpopulations, and that IL-2 and IL-7 differentially regulate the functions of DN alpha beta TCR+ T cells by inducing different types of effector cells.
Detection of Aircrafts on a Collision Course using Spatio-Temporal HOG (2013)

This work was supported by the EU funded myCopter project. Abstract. We have developed a method for the detection of both generic flight neighbouring aircrafts and those on a collision course. Our approach employs a sliding window linear Support Vector Machine (SVM) classifier with a Histogram of Oriented Gradients (HOG) feature representation. An extension of this approach to the spatio-temporal domain is also considered and we demonstrate its advantage for the detection of aircrafts on a collision path. We evaluated our approach for the detection of both small rotorcraft and larger fixed-wing aircrafts in challenging video sequences. Our results show that aircrafts on a collision course can be detected more reliably than when assuming a generic flight path. This is very interesting in practice, since this case is of critical importance. We also show that our spatio-temporal approach improves the detection accuracy with respect to conventional singleframe approaches. 1
Smart Files: Combining the Advantages of DBMS and WfMS with the Simplicity and Flexibility of Spreadsheets. (2005)

Even though database management as well as workflow management systems have significant advantages, spreadsheets exchanged by e-mail are still in widespread use for many processes within an enterprise, causing problems such as poor data-quality and lack of process monitoring. This paper analyzes reasons for office-document based workflows (ODBWf) and presents an alternative solution that combines the advantages of DBMS and WfMS with the flexibility and simplicity of office documents. This paper introduces an autonomous mobile document-management-system based on a ‘smart’ file. This file is executable and contains a managed resource part where files can be stored. Any read/write access to its resource part is managed by the file itself; it controls who can do what and automatically synchronizes changes to other systems such as process-monitoring or business intelligence tools. Proven concepts from DBMS, such as triggers, integrity constraints and multi-user support are utilized to improve ODBWfs without restraining their flexibility.
LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy (2012)

Aurora A is overexpressed in majority of breast carcinomas. With the exception of BRCA1 and PHLDA1, no oncogenic Aurora A substrates are known in breast cancer. In this study, a chemical genetic approach was used to identify malignant targets of Aurora A, which revealed LIMK2 as a novel Aurora A substrate. Aurora A regulates LIMK2 kinase activity, subcellular localization and protein levels by direct phosphorylation at S283, T494 and T505. In response, LIMK2 also positively regulates the level of Aurora A, thereby engaging in a positive-feedback loop, promoting Aurora-A-mediated oncogenic pathways. Most importantly, LIMK2 ablation fully abrogates Aurora-A-mediated tumorigenesis in nude mice, suggesting that LIMK2 is a key oncogenic effector of Aurora A. Furthermore, LIMK2 ablation acts synergistically with inhibition of Aurora A in promoting cell death. Finally, Aurora-A-mediated upregulation of LIMK2 appears to be a common mechanism in many cancers. LIMK2 inhibition or ablation is therefore an alternative approach for modulating Aurora A deregulation in cancer.
Genetic evolution of influenza H9N2 viruses isolated from various hosts in China from 1994 to 2013 (2017)

Influenza H9N2 subtype viruses and their reassortants (such as H7N9) are posing increasing threats to birds and humans in China. During 2009-2013, multiple novel subtype viruses with H9N2 original genes emerged in China. Yet, the genetic evolution of H9N2 viruses in various host organisms in China has not been systematically investigated since 2009. In the present study, we performed large-scale sequence analysis of H9N2 viral genomes from public databases, representing the spectrum of viruses isolated from birds, mammals and humans in China from 1994 to 2013, and updated the clade classification for each segment. We identified 117 distinct genotypes in 730 H9N2 viruses. We analyzed the sequences of all eight segments in each virus and found three important time points: the years 2000, 2006 and 2010. In the periods divided by these years, genotypic diversity, geographic distribution and host range changed considerably. Genotypic diversity fluctuated greatly in 2000 and 2006. Since 2010, a single genotype became predominant in poultry throughout China, and the eastern coastal region became the newly identified epidemic center. Throughout their 20-year prevalence in China, H9N2 influenza viruses have emerged and adapted from aquatic birds to chickens. The minor avian species and wild birds exacerbated H9N2 genotypes by providing diversified genes, and chickens were the most prevalent vector in which the viruses evolved and expanded their prevalence. It is the necessity for surveillance and disease control on live-bird markets, poultry farms and wild-bird habitats in China.
HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope (2018)

HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide ("Man<sub>9</sub>-V3") for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly neutralizing antibody (bnAb) lineage ("DH270"), to visualize the epitope on Env and to study how affinity maturation of the lineage proceeded. Unlike many previous V3 mimetics, Man<sub>9</sub>-V3 encompasses two key features of the V3 region recognized by V3-glycan bnAbs-the conserved GDIR motif and the N332 glycan. In our structure of an antibody fragment of a lineage member, DH270.6, in complex with the V3 glycopeptide, the conformation of the antibody-bound glycopeptide conforms closely to that of the corresponding segment in an intact HIV-1 Env trimer. An additional structure identifies roles for two critical mutations in the development of breadth. The results suggest a strategy for use of a V3 glycopeptide as a vaccine immunogen.
Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells (2022)

Our data suggest that cord blood-derived and blood-derived cDCs are a good surrogate to study treatment responses in human tumor cDCs. While most cDCs in human tumors display a non-activated phenotype, TL8-506 combinations drive human tumor cDCs towards an immunostimulatory phenotype associated with Th1 responses on stimulation. Hence, TL8-506-based combinations may be promising candidates to initiate or boost antitumor responses in patients with cancer.