gebhart/patrepeval huggingface dataset:
Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini. (1990)

We have shown previously that guanine nucleotide-binding protein (G protein) beta gamma complexes purified from bovine brain membranes are methyl esterified on a C-terminal cysteine residue of the gamma polypeptide. In the present study, 3H-methylated G beta gamma complexes cleaved to their constituent amino acids by exhaustive proteolysis were shown to contain radiolabeled material that coeluted with geranylgeranylcysteine methyl ester on reversed-phase HPLC and two TLC systems. Further treatment by performic acid oxidation yielded radiolabeled material that coeluted with L-cysteic acid methyl ester, verifying that the prenyl modification occurs on a C-terminal cysteine residue. Analysis by gas chromatography-coupled mass spectrometry of material released from purified G beta gamma by treatment with Raney nickel positively identified the covalently bound lipid as an all-trans-geranylgeranyl (C20) isoprenoid moiety. To delineate the distribution of this modification among gamma subunits, purified G beta gamma complexes were separated into 5-kDa (gamma 5) and 6-kDa (gamma 6) forms of the gamma polypeptide by reversed-phase HPLC. Gas chromatography-coupled mass spectrometry analyses of Raney nickel-treated purified gamma 5 and gamma 6 subunits showed that both polypeptides were modified by geranylgeranylation. These results demonstrate that at least two forms of brain gamma subunit are posttranslationally modified by geranylgeranylation and carboxyl methylation. These modifications may be important for targeting G beta gamma complexes to membranes.
The Influence of Lateral Fluoro-Substituents on TGB Phases in Chiral Propiolates (1995)

Abstract The transition temperatures and associated enthalpies of chiral and racemic 1-methylheptyl 4′-[(2- or 3-fluoro-4-alkoxyphenyl)propioloyl-oxy]biphenyl-4-carboxylates are reported along with phase diagrams for binary mixtures of (R)- and (S)-isomers. The position of the fluoro substituent was found to influence the formation of twist grain boundary phases both in the enantiomers and in binary mixtures of enantiomers. DSC studies revealed that the enantiomeric 3-fluoro compounds possessed a diffuse liquid-liquid transition above the clearing point, which did not arise for the racemates or for the 2-fluoro analogues. Circular dichroism and optical rotation studies carried out over the temperature range of the diffuse liquid phase, confirm that a form of cybotactic, chiral organisation in the isotropic liquid is responsible for this phenomenon.
Spectroscopy using active diode laser stabilization by optical feedback (2023)

A cavity ring down spectroscopy (CRDS) system uses a free-running continuous wave (c.w.) diode laser stabilized by frequency-shifted optical feedback in the presence of strong reflections from a high-finesse Fabry-Perot resonator. The frequency-shifted feedback stabilization eliminates the need for tightly controlling the relative positions of the laser and resonator. Non-frequency-shifted feedback is used for linewidth broadening. An acousto-optic modulator placed between the diode laser output and the resonator input frequency-shifts light reflected by the resonator input, causing the laser to cycle in phase with a period equal to the inverse of the frequency-shift. The laser diode linewidth can be stabilized from several MHz for high resolution spectroscopy of species at low pressures, to several hundred MHz for lower resolution spectroscopy of species at atmospheric pressures.
Structure of nitrated sulfobenzoic anhydride obtained from sulfobenzoic anhydride or saccharin (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of nitrated sulfobenzoic anhydride obtained from sulfobenzoic anhydride or saccharinJules B. Puschett, Butti S. Rao, and Krzysztof MatyjaszewskiCite this: J. Org. Chem. 1990, 55, 19, 5403–5404Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://pubs.acs.org/doi/10.1021/jo00306a020https://doi.org/10.1021/jo00306a020research-articleACS PublicationsRequest reuse permissionsArticle Views165Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An optimised architecture for radix-2 Montgomery modular multiplication on FPGA (2011)

In this paper, the algorithm and the hardware implementation of radix-2 Montgomery modular multiplication (MMM) are presented. The operation’s performances depend on the radix and the modulus size. The MMM with big modulus requires a large area for its implementation. The objective of this work is to realise an optimised intellectual property (IP) to perform this operation with a reduced area, independent of the modulus size, dedicated to low rate cryptographic applications. Our architecture uses a fixed data path size w to compute the MMM of two n -bits operands, with n >> w . To store these operands, we use embedded memory blocks (SelectRam), instead of long registers to overcome the routing complexity which is a timing consumer. The arithmetic unit (AU) is optimised at the low level (CLB), resulting in high performances AU. The proposed architecture is suitable to hybrid cryptosystem where both the symmetric and asymmetric cryptographies are used.
CMOS-SOI-MEMS transistor (TeraMOS) for Terahertz Imaging (2009)

This study presents a new sensor for Terahertz Imaging, dubbed here as TeraMOS, which is based on several leading technologies: CMOS-SOI (Silicon on Insulator), MEMS (Micro Electro Mechanical Systems) and Terahertz Photonics. The paper focuses on the electrical characterization of CMOS-SOI "virgin" (unreleased) transistors fabricated in the IBM 0.18¿m RF CMOS-SOI advanced process. By applying MEMS post processing to thermally isolate the transistors, the resulting CMOS-SOI-MEMS transistors become highly sensitive active bolometers - the TeraMOS sensors. The measured Temperature Coefficient of Current (TCC) as a function of temperature, gate voltage and drain current is presented. A new suggested figure of merit for the TeraMOS sensors is defined by TCC <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ·I and measured values of it are presented.
Correlates of response to IL-2 therapy in patients treated for metastatic renal cancer and melanoma. (2006)

Renal cancer and melanoma displayed separate prognostic indicators with respect to response from interleukin-2 therapy. Although significant correlates to response were identified, there was much variability and a reliable predictive model of response to therapy could not be formulated based on these results.
Tetracenomycin M, a Novel Genetically Engineered Tetracenomycin Resulting from a Combination of Mithramycin and Tetracenomycin Biosynthetic Genes (1997)

Abstract The hybrid strain Streptomyces glaucescens Tü49 (pGB7) contains recombined genes of the tetracenomycin C ( 4 ) and the mithramycin ( 6 ) biosynthesis cluster. It was designed by the trans formation of plasmid pGB7 into the tetracenomycin producer Streptomyces glaucescens Tü49. Plasmid pGB7 carries the minimal polyketide synthase (PKS) genes of mithramycin biosynthesis ( mtmP, mtmK, mtmS ) along with its upstream ( mtmX , which encodes a gene product of unknown function) and downstream flanking genes (the ketoreductasecoding mtmT1 and fragments of mtmO 1 , which encodes an oxygenase). It was assumed that early intermediates of the wellknown biosynthesis of 4 , such as tetracenomycin F 2 ( 3 ) or very similar molecules, are likely to also serve as intermediates of the biosynthesis of aureolic acid antibiotics, such as 6 . Thus, the enzymes of both parent biosynthetic pathways should be able to act on such intermediates, and several hybrid molecules were expected. Although the experiment resulted in new products, only the novel hybrid natural product tetracenomycin M ( 1 ), whose constitution was determined unambigously by spectroscopic methods, was obtained in larger amounts. The formation of 1 can be explained, if a combination of enzymes of both parent biosynthetic pathways is taken into consideration. When plasmid pGB7 is transformed into Streptomyces lividans TK21, that is, a strain which does not produce any secondary metabolites under our laboratory conditions, the production of SEK15 ( 2 ) is observed. The latter is well known as the product of the minimal PKS of decaketides, and its exclusive production indicates that the aureolic acid antibiotics are constructed via a single decaketide chain and that the enzyme products of the flanking genes mtmX, mtmT1 , and mtmO1 cannot contribute in this second experiment.
Molecular Simulation of a Zn–Triazamacrocyle Metal–Organic Frameworks Family with Extraframework Anions (2011)

We report an investigation by means of adsorption experiments and molecular simulation of the behavior of a recently synthesized cationic metal–organic framework. We used a combination of quantum chemistry calculations and classical forcefield-based Grand Canonical Monte Carlo simulations to shed light onto the localization of extra-framework halogenide anions in the material. We also studied the adsorption of small gas molecules into the pores of the material using molecular simulation and investigated the coadsorption of binary gas mixtures.
Design, performance, and calibration of CMS hadron-barrel calorimeter wedges (2008)

Extensive measurements have been made with pions, electrons and muons on four production wedges of the compact muon solenoid (CMS) hadron barrel (HB) calorimeter in the H2 beam line at CERN with particle momenta varying from 20 to 300 GeV/c. The time structure of the events was measured with the full chain of preproduction front-end electronics running at 34 MHz. Moving-wire radioactive source data were also collected for all scintillator layers in the HB. The energy dependent time slewing effect was measured and tuned for optimal performance.
FILTRE STOP BANDE ACTIF (2012)

La presente invention concerne un filtre stop bande actif comprenant une entree de filtre et une sortie de filtre reliees par une ligne de transmission LT, un resonateur RE couple a la ligne de transmission et connectable a une impedance de charge (Q1, L, R, C; C; Varactor). Entre le resonateur et l'impedance de charge, est monte un moyen d'activation (CM, diode PIN) de la fonction de filtrage dans une bande de fonctionnement choisie. Le filtre est utilisable dans des terminaux multistandards.
Development and clinical application of a deep learning model to identify acute infarct on magnetic resonance imaging (2022)

Stroke is a leading cause of death and disability. The ability to quickly identify the presence of acute infarct and quantify the volume on magnetic resonance imaging (MRI) has important treatment implications. We developed a machine learning model that used the apparent diffusion coefficient and diffusion weighted imaging series. It was trained on 6,657 MRI studies from Massachusetts General Hospital (MGH; Boston, USA). All studies were labelled positive or negative for infarct (classification annotation) with 377 having the region of interest outlined (segmentation annotation). The different annotation types facilitated training on more studies while not requiring the extensive time to manually segment every study. We initially validated the model on studies sequestered from the training set. We then tested the model on studies from three clinical scenarios: consecutive stroke team activations for 6-months at MGH, consecutive stroke team activations for 6-months at a hospital that did not provide training data (Brigham and Women's Hospital [BWH]; Boston, USA), and an international site (Diagnósticos da América SA [DASA]; Brazil). The model results were compared to radiologist ground truth interpretations. The model performed better when trained on classification and segmentation annotations (area under the receiver operating curve [AUROC] 0.995 [95% CI 0.992-0.998] and median Dice coefficient for segmentation overlap of 0.797 [IQR 0.642-0.861]) compared to segmentation annotations alone (AUROC 0.982 [95% CI 0.972-0.990] and Dice coefficient 0.776 [IQR 0.584-0.857]). The model accurately identified infarcts for MGH stroke team activations (AUROC 0.964 [95% CI 0.943-0.982], 381 studies), BWH stroke team activations (AUROC 0.981 [95% CI 0.966-0.993], 247 studies), and at DASA (AUROC 0.998 [95% CI 0.993-1.000], 171 studies). The model accurately segmented infarcts with Pearson correlation comparing model output and ground truth volumes between 0.968 and 0.986 for the three scenarios. Acute infarct can be accurately detected and segmented on MRI in real-world clinical scenarios using a machine learning model.
Calcitonin mRNA polymorphism: peptide switching associated with alternative RNA splicing events. (1982)

Evidence is presented which supports a model proposing that differential RNA splicing events may be used in expression of genes of the endocrine system to generate alternative polypeptide hormones. We previously reported that variation in the expression of the gene encoding the small polypeptide hormone calcitonin is associated with the production of a new calcitonin-like or pseudo-calcitonin (psi Cal) mRNA. A plasmid containing psi Cal cDNA sequences has been constructed, and calcitonin genomic clones have been isolated. Hybridization analysis reveals that calcitonin and psi Cal sequences are chromosomally linked and are present in the same nuclear RNA transcripts. Both calcitonin and psi Cal mRNAs are functional and encode different polypeptide products. These data are compatible with the proposed model that alternative RNA splicing of the transcript(s) of the calcitonin gene ultimately results in the production of different polypeptide products.
Size Exclusion HPLC Detection of Small-Size Impurities as a Complementary Means for Quality Analysis of Extracellular Vesicles (2015)

Abstract non disponibile
Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors (2017)

Zika virus (ZIKV) shares a high degree of homology with dengue virus (DENV), suggesting that preexisting immunity to DENV could affect immune responses to ZIKV. We have tracked the evolution of ZIKV-induced B cell responses in three DENV-experienced donors. The acute antibody (plasmablast) responses were characterized by relatively high somatic hypermutation and a bias toward DENV binding and neutralization, implying the early activation of DENV clones. A DENV-naïve donor in contrast showed a classical primary plasmablast response. Five months after infection, the DENV-experienced donors developed potent type-specific ZIKV neutralizing antibody responses in addition to DENV cross-reactive responses. Because cross-reactive responses were poorly neutralizing and associated with enhanced ZIKV infection in vitro, preexisting DENV immunity could negatively affect protective antibody responses to ZIKV. The observed effects are epitope-dependent, suggesting that a ZIKV vaccine should be carefully designed for DENV-seropositive populations.
Numerical Speckle Simulation Model Using Generalized Harvey-Shack Method (2016)

We propose the numerical method for simulating speckle from surface. By utilizing generalized Harvey-Shack method, speckle profile reflected from large distance could be obtained and inspected with varying parameters.
Novel Lignin-Capped Silver Nanoparticles against Multidrug-Resistant Bacteria (2021)

The emergence of bacteria resistant to antibiotics and the resulting infections are increasingly becoming a public health issue. Multidrug-resistant (MDR) bacteria are responsible for infections leading to increased morbidity and mortality in hospitals, prolonged time of hospitalization, and additional burden to financial costs. Therefore, there is an urgent need for novel antibacterial agents that will both treat MDR infections and outsmart the bacterial evolutionary mechanisms, preventing further resistance development. In this study, a green synthesis employing nontoxic lignin as both reducing and capping agents was adopted to formulate stable and biocompatible silver-lignin nanoparticles (NPs) exhibiting antibacterial activity. The resulting silver-lignin NPs were approximately 20 nm in diameter and did not agglomerate after one year of storage at 4 °C. They were able to inhibit the growth of a panel of MDR clinical isolates, including <i>Staphylococcus aureus</i>, <i>Staphylococcus epidermidis</i>, <i>Pseudomonas aeruginosa</i>, <i>Klebsiella pneumoniae</i>, and <i>Acinetobacter baumannii</i>, at concentrations that did not affect the viability of a monocyte-derived THP-1 human cell line. Furthermore, the exposure of silver-lignin NPs to the THP-1 cells led to a significant increase in the secretion of the anti-inflammatory cytokine IL-10, demonstrating the potential of these particles to act as an antimicrobial and anti-inflammatory agent simultaneously. <i>P. aeruginosa</i> genes linked with efflux, heavy metal resistance, capsular biosynthesis, and quorum sensing were investigated for changes in gene expression upon sublethal exposure to the silver-lignin NPs. Genes encoding for membrane proteins with an efflux function were upregulated. However, all other genes were membrane proteins that did not efflux metals and were downregulated.
Ga Adlayer Governed Surface Defect Evolution of (0001)GaN Films Grown by Plasma-Assisted Molecular Beam Epitaxy (2005)

The impact of the Ga adlayer coverage onto the surface morphologies and pit densities of GaN (0001) films grown by plasma-assisted molecular beam epitaxy (PAMBE) has been studied using quantitative in situ quadrupole mass spectrometry (QMS). As the equilibrium Ga adlayer coverages rise continuously from 0 to 2.5 monolayers (ML) the surface pit densities decrease from ∼2×10 9 cm -2 to zero, yielding characteristic step-flow and spiral growth hillock features. These results show that there is a direct and quantitative link between Ga adlayer coverage, adatom diffusion and surface defect structure without any discontinuities.
Mitigating the effects of intermittent interference on Bluetooth ad hoc networks (2003)

Bluetooth is a promising wireless technology aiming at supporting electronic devices to be instantly interconnected into short-range ad hoc networks. Previous studies show that since Bluetooth operates in the unlicensed 2.45 GHz frequency band, the presence of multiple piconets in the vicinity creates intermittent interference on signal reception which, in turn, degrades the overall throughput of the network. In order to cope up with this interference source, this paper proposes a sophisticated interference aware Bluetooth segmentation algorithm (IBLUES), where Bluetooth packet types are selected depending on the packet success probability, which is calculated based on the interference generated by multiple piconets. Among other things, we show that when the number of bridge nodes are larger than five the propagation delay between piconets increases rapidly. We have also observed a drastic overhead in the current Bluetooth piconet switching procedure and conclude that future enhancements to this procedure are crucial to efficiency of Bluetooth-based ad hoc networking.
Operation, design and control of dual H-bridge-based isolated bidirectional DC–DC converter (2008)

The operation, design and control of an isolated bidirectional DC–DC converter for hybrid electric vehicle energy management applications are discussed. Different operation modes and boundary conditions are distinguished by phase-shift angle and load conditions. The absolute and relative output voltage ripple was derived. The dead-band effect and safe operational area are further investigated. The relations between output power and leakage inductance and switching frequency are also presented. The proposed converter was simulated and a prototype was built and tested. Experiments on the converter&apos;s steady state and transient operations validated the design and simulation.
Soccer Video Summarization System Based on Hidden Markov Model with Multiple MPEG-7 Descriptors. (2003)

Pharmacy students differ in their needs for educational support in developing their patient counseling competency. These differences are to be taken into account in educational programs addressed to student's patient counseling competency.
Ultrasonic scattering from cancellous bone: A review (2008)

This paper reviews theory, measurements, and computer simulations of scattering from cancellous bone reported by many laboratories. Three theoretical models (binary mixture, Faran cylinder, and weak scattering) for scattering from cancellous bone have demonstrated some consistency with measurements of backscatter. Backscatter is moderately correlated with bone mineral density in human calcaneus in vitro (r(2) = 0.66 - 0.68). Backscatter varies approximately as frequency cubed and trabecular thickness cubed in human calcaneus and femur in vitro. Backscatter from human calcaneus and bovine tibia exhibits substantial anisotropy. So far, backscatter has demonstrated only modest clinical utility. Computer simulation models have helped to elucidate mechanisms underlying scattering from cancellous bones.
Industrial Organization Theory and Experimental Economics (2001)

This outstanding collection spanning three decades comprises a superb selection of Charles R. Plott’s work in experimental economics. Market Institutions and Price Discovery contains papers which define problems, create laboratory methodology and produce the first results in many areas of experimental economics.
Supplemental Figure 1 from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer (2023)

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Near room temperature electrical injection lasing for dilute nitride Ga(NAsP)/GaP quantum-well structures grown by metal organic vapour phase epitaxy (2006)

Electrical injection lasing has been verified for GaP-based broad-area Ga(NAsP)/GaP single-quantum-well heterostructures near room temperature for the first time. The lasers have been grown by metal organic vapour phase epitaxy. Owing to the comparable lattice constants of this novel material system to that of Si, this novel dilute nitride III/V laser material might be applied for optoelectronic devices integrated to Si microelectronics in the future.
Probe the spin switching in spin-crossover materials: A micro magnetometer (2012)

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