gebhart/patrepeval huggingface dataset:
Continuous Soluble Ziegler‐Natta Ethylene Polymerizations in Reactor Trains, 2 – Estimation of Kinetic Parameters from Industrial Data (2008)

Abstract We show that it is possible to estimate kinetic parameters for complex mechanistic polymerization models from available industrial data. A methodology is developed for efficient handling and reconciliation of industrial data and is then applied to allow estimation of kinetic parameters for industrial ethylene polymerizations performed in reactor trains using soluble Ziegler‐Natta catalysts. The parameter estimation procedure is formulated as a nonlinear optimization procedure subject to hard and soft model and process constraints. Parameter estimates obtained for the catalyst system allow a very good description of actual industrial data used during the estimation process and also allow very good prediction of process performance when completely new operating conditions are considered. It is concluded that complex phenomenological models can be successfully fitted to actual industrial processes without the need to carry out extensive experimental tests in the laboratory. magnified image
Modeling the Dynamics of T Helper 17 Induction and Differentiation (2015)

Background: CD4+ T cells play important roles in orchestrating immune responses, maintaining homeostasis and offering a functional control of immune responses. Depending on the cytokine milieu, a naïve CD4+ T cell differentiates into different phenotypes. The T helper 17 (Th17) phenotype remains controversial since it has been identified as an inductor of inflammation, but it contributes to the regulatory arm of the immune response. With the increased availability of high-throughput datasets, data-driven computational modeling built upon a robust conceptual base becomes a powerful tool to build predictive, counterintuitive, dynamic gene expression networks. Results: We used a publicly available microarray dataset generated by Yosef et al [1]. to construct a dynamic model of Th17 differentiation. Following data treatment to tailor the data to our 2,000+ genes of interest, our data-driven modeling pipeline used the Ingenuity Pathway Analysis (IPA) platform to infer a proof-of-concept modeling network composed of 67 genes involved in induction, function, and maintenance of Th17 differentiation. In vitro time-course mRNA expression data was used to calibrate the network using COPASI. Computational simulations highlighted the potential role of IL-24 in shaping IL-17A producing responses, and local sensitivity analysis demonstrated that IL-24 is negatively correlated with FOXP3 expression, further regulating the balance between FOXP3 and ROR?. Moreover, NLRP3 was identified as another potential therapeutic target to treat Th17-driven pathologies. Local sensitivity analyses on NLRP3 highlighted the positive correlation of NLRP3 with IP-10, GM-CSF, IFN?, and IL-17A. Conclusions: We established a modeling pipeline for constructing and calibrating data-driven models of Th17 differentiation. Our results highlighted the role of IL-24, SGK1, and NLRP3 as key modulators of Th17 cell differentiation. This modeling pipeline is an example of a modeling environment for building computational models with deterministic and stochastic features to generate new mechanistic immunological knowledge and to identify novel therapeutic targets for human diseases.
A Surface-Normal Coupled-Quantum-Well Modulator at 1.55&lt;tex&gt;$mu$&lt;/tex&gt;m (2004)

We demonstrate a surface-normal coupled-quantum-well InGaAs-InAlAs electroabsorption modulator that provides optical modulation with a contrast ratio in excess of 1.5 at only 6 V. The device operates at 1.55 μm and is based on a novel strain-balanced layer structure. The operating voltage is about two times lower than that of a conventional square quantum-well modulator that achieves a comparable contrast ratio.
V. Epistola D. Guidonis Grandi, societatis regalis Londin. Socii, ad illust. Comitem D. Laurentium Magalotti, dictœ societatis socium, de natura proprietatibus soni (1709)

Abstract Elegantissimum Præsulis Armachani commentariolum de Sono, quod mihi nuper communicasti, summâ animi voluptate perlegi; at circa Semiplani figuram in calce ejus scripti commemoratam, in cujus potissimum expositione meam à te operam desiderari significaveras (sive ob argumenti ipsius difficultatem, ingenii mei viribus longè superiorem, sive ob diagrammatis Londino transmissi, minùs fortassè ad impressum exemplar exactam delineationem) vereor, ut satis assequi mentem Auctoris, tuisque votis pro merito respondere valuerim.
Pharyngeal timing and particle transport defects in Caenorhabditis elegans feeding mutants (2021)

Abstract The nematode C. elegans uses rhythmic muscle contractions (pumps) of the pharynx, a tubular feeding organ, to filter, transport, and crush food particles. A number of feeding mutants have been identified, including those with slow pharyngeal pumping rate, weak muscle contraction, defective muscle relaxation, and defective grinding of bacteria. Many aspects of these pharyngeal behavioral defects and how they affect pharyngeal function are not well understood. For example, the behavioral deficits underlying inefficient particle transport in ‘slippery’ mutants have been unclear. Here we use high speed video microscopy to describe pharyngeal pumping behaviors and particle transport in wild-type animals and in feeding mutants. Different ‘slippery’ mutants exhibit distinct defects including weak isthmus contraction, failure to trap particles in the anterior isthmus, and abnormal timing of contraction and relaxation in pharyngeal compartments. Our results show that multiple deficits in pharyngeal timing or contraction can cause defects in particle transport.
Ein carbocyclisches Carben als effizienter Katalysatorligand für C‐C‐Kupplungen (2006)

Ein neuer Spieler auf dem Feld: Carbocyclische Carbene sind möglicherweise noch bessere Steuerliganden in der C-C-Kupplungskatalyse als N-heterocyclische Carbene (NHCs). So sind einfach herzustellende, thermisch und gegenüber Säuren sehr stabile PdII-Komplexe von Cycloheptatrienyliden (siehe Abbildung) in der C-C-Kupplungskatalyse den bekannten NHC-Komplexen mindestens ebenbürtig, teils überlegen.
Bilinear Observer/Kalman Filter Identification (2014)

Bilinear systems are important per se since several phenomena in engineering and other fields are inherently bilinear. Even more interestingly, bilinear systems can approximate more general nonlinear systems, providing a promising approach to handle various nonlinear identification and control problems, such as satellite attitude control. This paper develops and demonstrates via numerical examples a method for discrete-time state-space model identification for bilinear systems in the presence of noise in the process and in the measurements. The formulation relies on a bilinear observer which is proven to have properties similar to the linear Kalman filter under the sole additional assumption of stationary white excitation input, and on a novel approach to system identification based on the estimation of the observer residuals. The latter are used to construct a new, noise-free identification problem, in which the observer is identified and the matrices of the system state-space model are recovered. The resulting method represents the bilinear counterpart of the Observer/Kalman filter Identification (OKID) approach for linear systems, originally developed for the identification of lightly-damped structures and distributed by NASA.
Ab initio molecular orbital calculations on hydrogen bonding in binary water-alcohol mixtures: (CH3OH)2(H2O), (CH3OH) (H2O)2, and (CF3CH2OH)(H2O) (2009)

Ab initio LCAO-SCF molecular orbital calculations have been performed on open-chain and cyclic trimers containing methanol and water and on dimers containing 2,2,2-trifluoroethanoI and water. These calculations were done in conjunction with experimental studies of molecular association in vapors of binary mixtures. Equilibrium structures and energies were determined using the minimal STO-3G basis set. The 2:1 and 1:2 methanol-water cyclic trimers have similar binding energies and are more stable than their respective open-chain trimers. Limited calculations were carried out to assess the importance of polarization functions and correlation energy in the methanol-water trimers. These calculations confirmed the STO-3G predictions. The most stable trifluoroethanol-water dimer has an O—H ⃛O and an H ⃛F hydrogen bond. It has a larger interaction energy than either a trifluoroethanol dimer or a water dimer.
Ado-trastuzumab emtansine in patients with HER2 amplified salivary gland cancers (SGCs): Results from a phase II basket trial. (2019)

6001 Background: SGCs are rare tumors with no approved therapy for metastatic disease. HER2 amplification occurs in 8% among all SGC histologies, and 25-33% of the aggressive salivary duct carcinoma (SDC) histologic subtype. We hypothesized that ado-trastuzumab emtansine, a HER2 targeted antibody drug conjugate, may be clinically active in these patients. Methods: A cohort of patients with HER2 amplified SGCs were enrolled into a multi-histology basket trial of ado-trastuzumab emtansine, treated at 3.6mg/kg IV every 3 weeks. The primary endpoint was overall response rate (ORR) by RECIST v1.1 or PERCIST. A Simon two-stage optimal design was applied with type I error rate under 2.7%, power of 89%, H0 10%, H1 40%; H0 will be rejected if 6 or more responses are observed in 24 patients. Other endpoints include duration of response (DOR), progression-free survival (PFS), and toxicity. HER2 amplification was identified by next generation sequencing (NGS), and tumors were subsequently tested by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). Fluorescence lifetime imaging microscopy - Förster resonance energy transfer (FLIM-FRET) assessed the propensity for HER2-HER3 heterodimerization, which leads to receptor internalization. Results: 10 patients with HER2 amplified SGCs were treated. The median age was 65 (range 36-90 years), 90% were male. The median lines of prior systemic therapy was 2 (range 0-3). ORR was 90% (9/10, 95% CI 56-100%) including 5 complete responses after prior trastuzumab, pertuzumab and anti-androgen therapy. After a median follow up period of 12 months (range 4-20 months), median DOR (range 2-19+) and median PFS (95% CI 4–22+ months) were not reached. Toxicities included grade 1 or 2 infusion reaction, thrombocytopenia and transaminitis; there were no treatment related deaths. HER2 amplification by NGS (fold change 2.8 to 22.8) correlated with HER2/CEP17≥2 by FISH (8/8 tested) or IHC3+ (10/10 tested). FLIM-FRET tested positive in 3/3. Conclusions: Ado-trastuzumab emtansine is highly efficacious in patients with HER2 amplified SGCs as identified by NGS. This study has met its primary endpoint, and cohort expansion is warranted to confirm these results. Clinical trial information: NCT02675829.
Equalization requirements for series VRLA batteries (2002)

State-of-charge (SOC) balance is a necessary task in any high-rate series battery system. This equalization task is evaluated here through cycling and hybrid vehicle platform tests of valve-regulated lead-acid (VRLA) batteries. It is shown that when voltage matching is used as the basis for SOC equalization, voltage differences must be kept small. An upper limit of 15 mV/cell was found from the tests, although a limit of 10 mV/cell is more realistic for a practical system. A diffusion model is developed for voltage-based equalization processes. A switched-capacitor equalization approach introduced previously is shown to be a low-cost way to meet the accuracy requirements while allowing the charge diffusion process to be accelerated. The tests show that switched-capacitor equalization supports lifetime extension in series strings.
ChemInform Abstract: Exceptionally E‐ and β‐Selective NHC—Cu‐Catalyzed Proto‐Silyl Additions to Terminal Alkynes and Site‐ and Enantioselective Proto‐Boryl Additions to the Resulting Vinylsilanes: Synthesis of Enantiomerically Enriched Vicinal and Geminal Borosilanes. (2013)

Abstract Protosilylation of aliphatic and aromatic terminal alkynes proceeds with complete (E)‐β‐selectivity.
Microstructural Development and Catalytic Performance of Au−Pd Nanoparticles on Al2O3 Supports: The Effect of Heat Treatment Temperature and Atmosphere (2008)

Au−Pd nanoparticles supported on a variety of oxides are known to be highly active catalysts for a number of interesting reactions, including the direct synthesis of H2O2 from H2 and O2. A systematic series of Au−Pd/Al2O3 catalysts, subjected to a variety of heat treatments, have been examined by STEM-XEDS and XPS in an effort to track the microstructural development of the bimetallic particles. It was observed that the nature and size distribution of the AuPd particles was highly dependent upon both the heat treatment temperature and the atmosphere. As synthesized particles were homogeneous alloys, but subsequent calcination in air produced metal particles which showed a progressive enrichment of Pd at their surface. The change from homogeneous alloy to Pd-rich shell/Au-rich core morphology and increase in average particle size induced by the calcination treatment was accompanied by a significant decrease in the activity of the catalyst. However, the calcination step is deemed to be necessary to produce a stable reusable catalyst that resists leaching of the metal from the oxide surface into solution. Furthermore, it is shown that the subsequent reduction of a previously calcined catalyst is highly deleterious to its performance and stimulates many of the AuPd particles to “invert” and form a Pd-rich core/Au-rich shell morphology.
Subjective effects of sidetone during telephone conversation (1964)

DURING NORMAL conversation, a speaker hears himself externally through the air and internally through his head; these two paths produce what is known as sidetone When a speaker uses the telephone, a third sidetone path results from electrical connection between the transmitter and receiver of the telephone handset. The sidetone paths which occur during these two modes of conversation are shown in Fig. 1.
Model Predictive Control: MPC's Role in the Evolution of Power Electronics (2015)

The evolution of power electronics and its control has been mainly driven by industry applications and influenced by the development achieved in several technologies, such as power semiconductors, converter topologies, automatic control, and analog and digital electronics. Digital signal processors (DSPs), in particular, have experienced an exponential development in processing power, which until now has not been fully exploited for control purposes in power converters and drive applications. Presently, the control system technology finds itself in a paradigm-changing tipping point, in which more demanding control goals, system flexibility, and functionalities required by emerging applications are driving the control system technology development, in addition to stabilization and robustness, which was the main focus in the past. This article walks briefly through the history of the mainstream power converter control scene, with an emphasis on the more recent introduction of predictive control, and gives a glimpse on the challenges and possibilities ahead. Special attention is given to finite control set (FCS)-model predictive control (MPC), because of its simplicity, flexibility, inherent adaptation to power electronic circuits and their discrete nature, both in the finite amount of switching states and the digital implementation with microprocessors.
Dynamic communities in referral networks (2003)

Consider a decentralized agent-based approach for service location, where agents provide and consume services, and also cooperate with each other by giving referrals to other agents. That is, the agents form a referral network. Based on feedback from their users, the agents judge the quality of the services provided by others. Further, based on the judgments of service quality, the agents also judge the quality of the referrals given by others. The agents can thus adaptively select their neighbors in order to improve their local performance. The choices by the agents cause communities to emerge. According to our definition, an agent belongs to a community only if it has been useful to the other members of the community in prior interactions regarding a particular topic. Hence, the membership in different communities is determined based on relationships among the agents. This paper compares topic-sensitive communities of the above kind with communities as studied in traditional link analysis. It studies the correlation between the two kinds of communities as they emerge in referral networks and evaluates the two kinds of communities in terms of their effectiveness in locating service providers. 1
Broadband Fully Integrated GaN Power Amplifier With Minimum-Inductance BPF Matching and Two-Transistor AM-PM Compensation (2020)

In this paper, we present a design technique for broadband fully integrated GaN power amplifiers (PAs), with merged bandpass filter (BPF) and AM-PM compensation. The minimum-inductance BPF structure is used as the output matching network of the PA. A new theory of the minimum-inductance BPF is developed and it is shown that, compared to the standard BPF, it can be implemented using lower total inductance and provide higher out-of-band attenuation. Furthermore, using a two-transistor architecture, an AM-PM compensation technique is proposed where compressive and expansive nonlinearity profiles of the transistors' transconductance and gate-source capacitance are combined to achieve a linear total transconductance and input capacitance, over a wide power range. A fully integrated PA prototype, implemented in a 0.25-μm GaN-on-SiC process with 28-V supply, provides 35.1-38.9dBm output power, 45-61% drain efficiency (DE), 40-55% power-added efficiency (PAE), and 11.3-13.4dB power gain, across 2.0-4.0GHz. For a 256-QAM signal with 7.2-dB PAPR and 100-MHz bandwidth at 2.4GHz, it achieves 2.5% (-32.0dB) rms error vector magnitude (EVMrms) and -37.5/-37.6dBc adjacent channel leakage ratio (ACLR), while average output power and DE/PAE are respectively 30.1dBm and 20.6/19.5%, without predistortion. EVMrms and ACLR can be improved to 0.5% (-46dB) and -46.4/-46.8dBc by using digital predistortion (DPD).
Analysis of Femur Fracture in Aged Person's Fall (2004)

Femur fracture in aged people is a serious problem as it sometimes leads to be bedridden. Every year approximately 90,000 people in Japan are found to be suffered from femoral neck fracture. 75 percentages of the fractures are due to falling. Since bone density reduces with aging, the possibility of fracture in aged people is very high. In this study, stress distributions at different possible impact locations were analyzed using 3-dimensional Finite Element Method. As a result, it was clear that stress distribution around the femoral neck greatly depended on the impact location due to falling. The fracture risk was found to be increased rapidly with aging. Under applying the impact force at posterior direction in great trochanter, femoral neck showed the highest fracture risk.
Listeria monocytogenes-Infected Hepatocytes Are Targets of Major Histocompatibility Complex Class Ib-Restricted Antilisterial Cytotoxic T Lymphocytes (1998)

Subclinical infection of BALB/c mice with the intracellular bacterial pathogen Listeria monocytogenes results in the development of protective antilisterial immunity. L. monocytogenes can infect hepatocytes, and antilisterial cytotoxic T lymphocytes (CTL) lyse Listeria-infected hepatocytes in a major histocompatibility complex (MHC) class Ia-restricted manner. It remained to be determined whether L. monocytogenes-infected hepatocytes are susceptible to MHC class Ib-restricted cytolysis. In this study, we showed that hepatocytes express MHC class Ib molecule Qa-1(b) mRNA and protein. We further showed that Listeria-infected hepatocytes are susceptible to MHC class Ib-restricted cytolysis, since C57BL/6-derived Listeria-infected hepatocytes were lysed by BALB/c-derived antilisterial CTL. These results establish that Listeria-infected hepatocytes are susceptible to cytolysis by MHC class Ib restricted Listeria-specific CTL.
Measurement of forward W → eν production in pp collisions at s = 8 $$ \sqrt{s}=8 $$ TeV (2016)

A measurement of the cross-section for W e production in pp collisions is presented using data corresponding to an integrated luminosity of 2 fb -1 collected by the LHCb experiment at a centre-of-mass energy of s = 8 TeV. The electrons are required to have more than 20 GeV of transverse momentum and to lie between 2.00 and 4.25 in pseudorapidity. The inclusive W production cross-sections, where the W decays to e, are measured to be W + e + e = 1124.4 2.1 21.5 11.2 13.0 pb, W -e -e = 809.0 1.9 18.1 7.0 9.4 pb,
Photochemical reactions of matrix-isolated aluminum atoms with methane and molecular hydrogen. 3. Structure, bonding and reactivity (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical reactions of matrix-isolated aluminum atoms with methane and molecular hydrogen. 3. Structure, bonding and reactivityJ. Mark Parnis and Geoffrey A. OzinCite this: J. Phys. Chem. 1989, 93, 4, 1220–1225Publication Date (Print):February 1, 1989Publication History Published online1 May 2002Published inissue 1 February 1989https://pubs.acs.org/doi/10.1021/j100341a012https://doi.org/10.1021/j100341a012research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Layered Polymer Light Emitting Diode Prepared by Evaporative Spray Deposition from Ultradilute Solution (ESDUS) Technique at Various Substrate Temperature (2007)

The evaporative spray deposition from ultra-dilute solution (ESDUS) technique enables preparing a polymer layered structure. The bi-layer structure consisted of two π-conjugated polymers, where the top layer was deposited from tetrahydrofuran (THF) solution with the ESDUS technique onto the preceding bottom layer composed of the other THF-soluble polymer. It has been reported that the external quantum efficiency (EQE) of the polymer light emitting diode (PLED) having the bi-layer structure is significantly higher than a corresponding single-layer device. In the present study, the polymer bi-layer films are prepared at substrate temperatures of 65 °C and 80 °C. While the photoluminescence of the bi-layer film prepared at 80 °C indicated the separation of the two components in the film, that of the film at 65 °C suggested partially mixed structure. The PLED composed of the film at 80 °C exhibited significantly better performance than that at 65 °C and the PLED composed of the spin-coated mixed film. The mixture structure of the two component films can be controlled simply by the substrate temperature during ESDUS deposition.