gebhart/patrepeval huggingface dataset:
Interleukin-7 promotes autoimmune disease by enabling memory T cells to escape PD-1-mediated tolerance (164.21) (2011)

Abstract An important challenge in the therapy of immune-mediated inflammatory diseases is to control established disease, largely because autoreactive memory T lymphocytes are difficult to suppress or eliminate. Memory T cells depend on interleukin-7 (IL-7) for their generation and maintenance and genomic studies have associated the cytokine’s receptor, IL-7Rα, with increased risk for autoimmune diseases such as type 1 diabetes. Here we show that IL-7Rα blockade reverses hyperglycemia in the non-obese diabetic (NOD) mouse model of type 1 diabetes. Diabetogenic memory T cells deprived of IL-7 signals remained present in the lymphoid organs but expressed the inhibitory molecule Programmed Death 1 (PD-1), which is critical for preventing autoimmunity. Blocking the interaction of PD-1 with its ligand, PD-L1, in cured mice rapidly induced hyperglycemia, demonstrating that this mechanism inhibited memory responses to pancreatic islets after IL-7Rα blockade. Conversely, IL-7 suppressed PD-1 expression after T cell activation, indicating that IL-7 contributes to the pathogenesis of autoimmune diabetes by keeping memory T cells in a functionally competent, tolerance-resistant state. Our data uncover a novel link between IL-7 and the PD-1/PD-L1 tolerance pathway and identify IL-7Rα blockade as a potential therapeutic approach to induce PD-1-mediated inhibition of pathogenic memory T cells in established T cell-dependent inflammatory diseases.
From Field and Study (1958)

Journal Article Use of Nest Boxes by Wood Ducks in the San Joaquin Valley, California. Get access Richard H. Robinson Richard H. Robinson Monterey Peninsula CoUege, Monterey, California Search for other works by this author on: Oxford Academic Google Scholar The Condor, Volume 60, Issue 4, 1 July 1958, Pages 256–257, https://doi.org/10.2307/1365195 Published: 01 July 1958
Efficient Approach for Cd2+ and Ni2+ Removal and Recovery Using Mesoporous Adsorbent with Tunable Selectivity (2007)

Cadmium pollution from the manufacture and disposal of NiCd batteries remains an important problem in developing countries. Among the available remedial technologies, adsorption is popular because of its low cost and simplicity. The mesoporous NH2-MCM-41 displays good adsorption capacities for cadmium and nickel ions. This work demonstrated for the first time the use of the competition between complexant and sorbentto create high adsorption selectivity. The selectivity was manipulated by the judicious use of a chelating agent, thus achieving on-demand 100% selectivity for either Cd2+ or Ni2+ adsorption. Single and binary components adsorption studies, carried out with different metals and EDTA concentrations, solution compositions and pH, showed that NH2-MCM-41 adsorbs only cadmium with a capacity of 0.56 mmol g(-1) from binary mixtures at [EDTA]/[M2+] = 0.5 and pH 5. The NH2-MCM-41 displays 100% selectivityfor nickel adsorption at [EDTA]/[M2+] = 0.5 and pH 2 with a measured adsorption capacity of 0.50 mmol g(-1). Pure Cd2+ and Ni2+ solutions were recovered by a simple acid wash, and the regenerated adsorbent could be reused without lost of performance (i.e., adsorption capacity and selectivity).
Search for high-mass resonances decaying into τ-lepton pairs in pp collisions at s=7 TeV (2012)

A search for high-mass resonances decaying into + -is performed using a data sample of pp collisions at s = 7 TeV. The data were collected with the CMS detector at the LHC and correspond to an integrated luminosity of 4.9 fb -1 . The number of observed events is in agreement with the standard model predic-
Multimedia in <inline-formula><math altimg="none" display="inline" overflow="scroll"><mrow><msup><mi>JM</mi><mn>3</mn></msup></mrow></math></inline-formula> is a Win-Win for Authors and Subscribers (2007)

The <i>Journal of Micro/Nanopatterning, Materials, and Metrology</i> (JM3) publishes peer-reviewed papers on the core enabling technologies that address the patterning needs of the electronics industry.
Supplementary Text from Identification of Promiscuous KIF20A Long Peptides Bearing Both CD4<sup>+</sup> and CD8<sup>+</sup> T-cell Epitopes: KIF20A-Specific CD4<sup>+</sup> T-cell Immunity in Patients with Malignant Tumor (2023)

&lt;p&gt;Supplementary Text - PDF file 195K, Supplementary Methods and Figure legends&lt;/p&gt;
Micro Orientation and Anisotropy of Conductivity in Liquid Crystalline Polymer Films Filled with Carbon Nanotubes (2005)

In this communication we report the preferential orientation of single wall carbon nanotubes (SWNT) in a nematic liquid crystalline (LC) polymer matrix. The alignment of the nanotubes was characterized through anisotropy of electrical conductivity of the composite measured in directions parallel and perpendicular to the nematic director. The anisotropy of the nanocomposite films strongly depends on the nanotube concentration in the range from 1 to 10% and vanished at higher loads. The electrical conductivity of nanocomposites is related to their structural features revealed by atomic force microscopy and Raman spectroscopy experiments and is explained by a strong coupling between the nanotubes and the polymer matrix.
Microwave-Mediated Nickel-Catalyzed Cyclotrimerization Reactions:  Total Synthesis of Illudinine (2007)

Rapid and efficient [2 + 2 + 2] cyclotrimerization reactions were discovered through the application of microwave irradiation in conjunction with a Ni(CO)(2)(PPh(3))(2) catalyst. This enables the facile construction of highly substituted indane, isoindoline, and tetraline core structures. The developed microwave-mediated Ni-catalyzed cyclotrimerization reaction was employed as the key step in a concise synthesis of the isoquinoline natural product illudinine. This represents the first example of a Ni-catalyzed cyclotrimerization reaction in total synthesis.
Effect of nicotine on cerebellar granule neuron development (2001)

To assess the role of nicotinic cholinergic receptors (nAChR) on neuronal maturation, nAChR expression and the direct effects of nAChR activation were examined in cerebellar external granular layer (EGL) precursors isolated in vitro.Treatment of EGL neuroblasts with nicotine elicited a concentration-dependent increase in DNA content and synthesis, implying an increase in cell numbers.Pretreatment of cultures with the nAChR antagonist dihydro-β-erythroidine (DHBE) attenuated nicotine-induced changes in DNA abundance and synthesis.Furthermore, chronic nicotine treatment for 4-7 days promoted EGL cell survival.Epibatidine but not cytisine stimulated granule neuroblast DNA synthesis and survival.Survival effects mediated by nicotine and epibatidine were attenuated by pre-treating cultures with DHBE.Immunocytochemical analysis revealed that EGL neurons possessed α3, but not α4, nAChR immunoreactivity.Quantitative autoradiography was used to determine which nAChRs are present during the period of granule cell neurogenesis in vivo.On postnatal day 5, the EGL was intensely labeled by [ 3 H]epibatidine but virtually devoid of [ 3 H]-A85380 binding suggesting that a high concentration of α3 nAChRs is present in granule neuroblasts.The pharmacology of [ 3 H]-epibatidine displacement from EGL neurons also suggested an interaction with the α3-nAChR subunits.Together these data provide novel evidence that the activation of nAChRs directly affect the development of primary cerebellar neuroblasts and further suggest that the effects are mediated through the α3-nAChR subtype.
Related Article from Getting Knit-PI3Ky: PIK3CA Mutation Status to Direct Multimodality Therapy? (2023)

Related Article from Getting Knit-PI3Ky: PIK3CA Mutation Status to Direct Multimodality Therapy?
All-fiber Raman oscillator for the generation of radially and azimuthally polarized beams (2014)

In this paper we demonstrate a Raman fiber oscillator for the generation of radially and azimuthally polarized beams. The Raman fiber oscillator comprises a high NA fiber and two Fiber-Bragg Gratings (FBGs). Due to the high NA of the fiber, radially and azimuthally polarized modes are guided with their own effective refractive indexes, i.e. they are not degenerated. Therefore, the FBGs reflect these modes at different wavelengths. The mode that oscillates in the resonator can be selected by controlling the coupling lens and the polarization of the pump beam. Unfortunately, at the output of the fiber oscillator the output beams exhibit a non-circularly symmetric intensity profile as a result of a slightly elliptical fiber core. Consequently, the impact of elliptical cores on the polarization degeneracy has been analyzed in detail. In order to compensate for the elliptical core we applied a transverse force on the last few cm of the fiber. With this force the waveguide characteristic of the fiber is changed in such a way that a radially or azimuthally polarized doughnutshaped beam profile is observed. Thereby an output power of 480mW (400mW) was reached for the azimuthal (radial) polarization. The presented concept is wavelength agile and suitable for all-fiber microscopic setups, especially for STED-microscopy.
Transverse momentum dependence of inclusive primary charged-particle production in p–Pb collisions at $$\sqrt{s_\mathrm{{NN}}}=5.02~\text {TeV}$$ s NN = 5.02 TeV (2014)

The transverse momentum ( p T ) distribution of primary charged particles is measured at midrapidity in minimum-bias p-Pb collisions at s NN = 5.02 TeV with the ALICE detector at the LHC in the range 0.15 < p T < 50 GeV/c. The spectra are compared to the expectation based on binary collision scaling of particle production in pp collisions, leading to a nuclear modification factor consistent with unity for p T larger than 2 GeV/c, with a weak indication of a Cronin-like enhancement for p T around 4 GeV/c. The measurement is compared to theoretical calculations and to data in Pb-Pb collisions at s NN = 2.76 TeV.
Supplementary Figure Legends 1-3 from Potent <i>In vitro</i> and <i>In vivo</i> Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia (2023)

Supplementary Figure Legends 1-3 from Potent &lt;i&gt;In vitro&lt;/i&gt; and &lt;i&gt;In vivo&lt;/i&gt; Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia
Metalorganic Vapor Phase Epitaxy Growth of a High-Quality GaN/InGaN Single Quantum Well Structure Using a Misoriented SiC Substrate (1997)

A high-quality GaN/InGaN single quantum well (SQW) structure has been successfully grown using a misoriented 6H–SiC substrate, the face of which is tilted from (0001) toward [1120] by 3.5°, by low pressure metalorganic vapor phase epitaxy (MOVPE). A sharp emission, whose full-width at half maximum (FWHM) was 24.3 meV, from the GaN/InGaN SQW structure was observed at 385 nm in the 77 K photoluminescence spectrum. From the transmission electron microscopy (TEM) analysis, the dislocations in the GaN film grown on the misoriented substrate were bent from the c -direction, and the threading dislocations to the InGaN film on the GaN film were decreased. For the InGaN film grown on the misoriented substrate, only the sharp band edge emission, whose FWHM was 92.3 meV, was observed at 385 nm in the PL spectrum at 77 K. The dislocation density, which was estimated from TEM photographs, in the InGaN film on the GaN film grown on the misoriented substrate was about 5×10 8 cm -2 , which was nearly half of that grown on the (0001) substrate.
The effect of Bifidobacterium on intestinal bacterial flora and putrefactive products in hemodialysis. (1999)

透析患者は, その病態ゆえに, 腸内細菌叢の乱れに伴って, 腐敗産物の異常産生が予測される.今回, 透析患者の腸内細菌叢の検索と, 糞便中の腐敗産物の測定を行ったところ, 好気性菌の占める割合が高くアンモニアなど腐敗産物が高かった. 透析患者に対し腸溶性マイクロカプセルビフィズス菌製剤を投与することにより, 腸内細菌叢の改善と腐敗産物の産生が抑制されたことが判明した.本研究は透析患者に対して腸溶性マイクロカプセルピフィズス菌製剤の投与を行うことが腸内環境を改善し, 健康維持に役立つ手段の一つと考える.
Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care (2018)

Author(s): Giannobile, WV; Chai, Y; Chen, Y; Healy, KE; Klein, O; Lane, N; Longaker, MT; Lotz, JC; Mooney, DJ; Sfeir, CS; Urata, M; Wagner, WR; Wu, BM; Kohn, DH
A high resolution ultrasonic range measurement method using double frequencies and phase detection (2002)

An ultrasonic range measurement method is presented which uses a pair of transmit signals with different frequencies from each other and phase detection of a pair of received signals corresponding to the pair of transmit signals, respectively. Uncertainty of detected phases in relation to integral multiples of 2 /spl pi/ is eliminated using the pair of phases and one of the envelopes of the received signals. High resolution can be obtained since the range is detected based on the information of the phases of the received signals. Experiments were done in air using the frequencies of 180 kHz and 210 kHz, and resolution of 1% of the wavelength corresponding to the frequency of 210 kHz was obtained.
BrainIAK: The Brain Imaging Analysis Kit (2020)

Functional magnetic resonance imaging (fMRI) offers a rich source of data for studying the neural basis of cognition. Here, we describe the Brain Imaging Analysis Kit (BrainIAK), an open-source, free Python package that provides computationally-optimized solutions to key problems in advanced fMRI analysis. A variety of techniques are presently included in BrainIAK: intersubject correlation (ISC) and intersubject functional connectivity (ISFC), functional alignment via the shared response model (SRM), full correlation matrix analysis (FCMA), a Bayesian version of representational similarity analysis (BRSA), event segmentation using hidden Markov models, topographic factor analysis (TFA), inverted encoding models (IEM), an fMRI data simulator that uses noise characteristics from real data (fmrisim), and some emerging methods. These techniques have been optimized to leverage the efficiencies of high performance compute (HPC) clusters, and the same code can be seamlessly transferred from a laptop to a cluster. For each of the aforementioned techniques, we describe the data analysis problem that the technique is meant to solve, and how it solves that problem; we also include an example Jupyter notebook for each technique and an annotated bibliography of papers that have used and/or described that technique. In addition to the sections describing various analysis techniques in BrainIAK, we have included sections describing the future applications of BrainIAK to real-time fMRI, tutorials that we have developed and shared online to facilitate learning the techniques in BrainIAK, computational innovations in BrainIAK, and how to contribute to BrainIAK. We hope that this manuscript helps readers to understand how BrainIAK might be useful in their research.
Framework for Developping Behavioural Models From Physical Designs (2018)

Verification of high-precision nanometer analog and mixed-signal circuits has become very challenging because traditional Analog simulators do not have the capacity required to support the circuit complexity. As a result, they are not suitable for large analog, mixed-signal, and digital circuits as the run time is too long. To overcome this limitation and address the need of speed and accuracy behavioral models are developed. This article explains the development and implementation of a new digital environment to run analog and mixed signal systems. The proposed environment was tested to verify a 400Gbit/s coherent optical modem.
Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma (2005)

Defective function of the von Hippel-Lindau (VHL) tumor suppressor ablates proteolytic regulation of hypoxia-inducible factor alpha subunits (HIF-1alpha and HIF-2alpha), leading to constitutive activation of hypoxia pathways in renal cell carcinoma (RCC). Here we report a comparative analysis of the functions of HIF-1alpha and HIF-2alpha in RCC and non-RCC cells. We demonstrate common patterns of HIF-alpha isoform transcriptional selectivity in VHL-defective RCC that show consistent and striking differences from patterns in other cell types. We also show that HIF-alpha isoforms display unexpected suppressive interactions in RCC cells, with enhanced expression of HIF-2alpha suppressing HIF-1alpha and vice-versa. In VHL-defective RCC cells, we demonstrate that the protumorigenic genes encoding cyclin D1, transforming growth factor alpha, and vascular endothelial growth factor respond specifically to HIF-2alpha and that the proapoptotic gene encoding BNip3 responds positively to HIF-1alpha and negatively to HIF-2alpha, indicating that HIF-1alpha and HIF-2alpha have contrasting properties in the biology of RCC. In keeping with this, HIF-alpha isoform-specific transcriptional selectivity was matched by differential effects on the growth of RCC as tumor xenografts, with HIF-1alpha retarding and HIF-2alpha enhancing tumor growth. These findings indicate that therapeutic approaches to targeting of the HIF system, at least in this setting, will need to take account of HIF isoform-specific functions.
Sociedad Civil y Estado en la Filosofía del Derecho de Hegel (II) (2018)

En el texto que acabo de comentar ( **\ adems del estado y la sociedad civil, aparece la persona como momento lgico igualmente esencial al todo social. Vale la pena detenernos aqu un momento, no slo por razones obvias, sino tambin porque en este punto reside el mximo de concesiones que Hegel puede hacer al individualismo moderno dentro de un cuerpo de doctrina netamente pro-social. El individuo europeo moderno, tal como Hegel lo concibe, est formado por un conjunto de estratos superpuestos que vienen a ser sedimentacin permanente de experiencias histricas. Aqu hay, creo, una manera sutil de restablecer la anamnesis platnica. Las experiencias (a posteriori, diramos) vienen a constituir el sujeto y sus modos de actuacin (su a priori). Bajo esta perspectiva cobra sentido aquella tesis filosficamente escandalosa que afirmaba que la existencia precede a la esencia o que la naturaleza no es tal, sino una combinacin entre otras que en abstracto eran igualmente probables, pero que en concreto viene a resultar estable y estabilizada (estatalizada, podramos decir, estirando el hilo) porque era ms lgica. Cuando la accin se produce, aquel a priori se reactiva o rememora. Se hace presente entonces como portador de aquella lgica que le otorga substancialidad.
Impact of Power Granularity On Chip Thermal Modeling (2006)

In this paper we investigate the impact of the granularity of the power distribution for accurately predicting semiconductor chip temperature fields. Specifically, we calculate the transfer functions between power distributions and resulting temperature maps for various microprocessor packages and cooling conditions, which establish a minimum granularity required for accurate thermal analysis. The purpose of this paper is twofold: first, we like to provide some general guidelines for the impact of different power granularities on the global chip temperatures and second we intend to spike a broader discussion about to which extent small heating effects can affect chip temperatures for circuits under full operation. As such this work is not only beneficial for package and cooling solution engineering but also important to circuit designers and computer architects in their battle against hotspots in microprocessors
Catalytic Enhancement of SAPO-34 for Methanol Conversion to Light Olefins Using in Situ Metal Incorporation (2018)

Parent and MeAPSO-34 (Me = Cu, Ca, and W) catalysts were synthesized for methanol conversion to more valuable products such as light olefins. The effect of metal presence on the catalytic performance and physicochemical properties were investigated. The comprehensive characterizations, XRD, EDX, FESEM, FTIR, N2-BET, NH3-TPD, and DR UV–vis, have been applied to characterize the metal modified SAPO-34. Even though the crystallinity of MeAPSO-34s decreased compared to that of parent SAPO-34, the diffusion and acidity properties were improved. Good activity and selectivity for olefin production were observed for all synthesized catalysts. Metal incorporation to the framework of SAPO-34 enhanced the catalytic lifetime and propylene yield. The methanol conversion was stable for 1 h over MeAPSO-34 with W/F = 6.6 g h/mol at 350 °C and 1 bar. The deactivation rate was higher for the parent SAPO-34 as compared to MeAPSO-34. CaAPSO-34 favored propylene production, while CuAPSO-34 favored ethylene.
Chirality-Memory Molecule:  A D2-Symmetric Fully Substituted Porphyrin as a Conceptually New Chirality Sensor (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTChirality-Memory Molecule: A D2-Symmetric Fully Substituted Porphyrin as a Conceptually New Chirality SensorYoshio Furusho, Takayuki Kimura, Yukitami Mizuno, and Takuzo AidaView Author Information Department of Chemistry and Biotechnology Graduate School of Engineering The University of Tokyo Hongo, Bunkyo-ku, Tokyo 113, JapanCite this: J. Am. Chem. Soc. 1997, 119, 22, 5267–5268Publication Date (Web):June 4, 1997Publication History Received10 February 1997Published online4 June 1997Published inissue 1 June 1997https://pubs.acs.org/doi/10.1021/ja970431qhttps://doi.org/10.1021/ja970431qrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1726Altmetric-Citations152LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Absolute configuration,Chirality,Molecules,Optical properties,Pyrroles Get e-Alerts
Jumplike unravelings for non-Markovian open quantum systems (2004)

Non-Markovian evolution of an open quantum system can be ``unraveled'' into pure state trajectories generated by a non-Markovian stochastic (diffusive) Schr\"odinger equation, as introduced by Di\'osi, Gisin, and Strunz. Recently we have shown that such equations can be derived using the modal (hidden variable) interpretation of quantum mechanics. In this paper we generalize this theory to treat jumplike unravelings. To illustrate the jumplike behavior we consider a simple system: a classically driven (at Rabi frequency $\ensuremath{\Omega}$) two-level atom coupled linearly to a three mode optical bath, with a central frequency equal to the frequency of the atom, ${\ensuremath{\omega}}_{0}$, and the two side bands have frequencies ${\ensuremath{\omega}}_{0}\ifmmode\pm\else\textpm\fi{}\ensuremath{\Omega}$. In the large $\ensuremath{\Omega}$ limit we observed that the jumplike behavior is similar to that observed in this system with a Markovian (broad band) bath. This is expected as in the Markovian limit the fluorescence spectrum for a strongly driven two level atom takes the form of a Mollow triplet. However, the length of time for which the Markovian-like behavior persists depends upon which jumplike unraveling is used.