gebhart/patrepeval huggingface dataset:
Macrophage Inflammatory Protein Derivative ECI301 Enhances the Alarmin-Associated Abscopal Benefits of Tumor Radiotherapy (2014)

Radiotherapy can produce antitumor benefits beyond the local site of irradiation, an immune-based phenomenon known as the abscopal effect, but the mechanisms underlying these benefits are poorly understood. Preclinical studies of ECI301, a mutant derivative of macrophage inhibitory protein-1α, have shown that its administration can improve the antitumor effects of radiotherapy in a manner associated with a tumor-independent abscopal effect. In this article, we report that i.v. administration of ECI301 after intratumoral injection of tumor cell lysates can inhibit tumor growth, not only at the site of injection but also at nontreated sites. Effects of the tumor lysate were further recapitulated by intratumoral injection [corrected] of the alarmins HSP70 or HMGB1, but not HSP60, and i.v. administration [corrected] of ECI301 + HSP70 were sufficient to inhibit tumor growth. Although i.v. administration [corrected] of ECI301 + HMGB1 did not inhibit tumor growth, we found that administration of a neutralizing HMGB1 antibody neutralized the cooperative effects of ECI301 on tumor irradiation. Moreover, mice genetically deficient in TLR4, an immune pattern receptor that binds alarmins, including HMGB1 and HSP70, did not exhibit antitumor responses to irradiation with ECI301 administration. Although ECI301 was cleared rapidly from peripheral blood, it was found to bind avidly to HSP70 and HMGB1 in vitro. Our results suggest a model in which sequential release of the alarmins HSP70 and HMGB1 from a tumor by irradiation may trap circulating ECI301, thereby licensing or restoring tumor immunosurveillance capabilities of natural killer cells or CD4(+) and CD8(+) T cells against tumor cells that may evade irradiation. Cancer Res; 74(18); 5070-8. ©2014 AACR.
Taking a quantum leap in time to solution for simulations of high-Tc superconductors (2013)

We present a new quantum cluster algorithm to simulate models of high-Tc superconductors. This algorithm extends current methods with continuous lattice self-energies, thereby removing artificial long-range correlations. This cures the fermionic sign problem in the underlying quantum Monte Carlo solver for large clusters and realistic values of the Coulomb interaction in the entire temperature range of interest. We find that the new algorithm improves time-to-solution by nine orders of magnitude compared to current, state of the art quantum cluster simulations. An efficient implementation is given, which ports to multi-core as well as hybrid CPU-GPU systems. Running on 18,600 nodes on ORNL's Titan supercomputer enables us to compute a converged value of Tc/t = 0.053 ± 0.0014 for a 28 site cluster in the 2D Hubbard model with U/t = 7 at 10% hole doping. Typical simulations on Titan sustain between 9.2 and 15.4 petaflops (double precision measured over full run), depending on configuration and parameters used.
Do That Again: Evaluating Spoken Dialogue Interfaces (2000)

We present a new technique for evaluating spoken dialogue interfaces that allows us to separate the dialogue behavior from the rest of the speech system. By using a dialogue simulator that we have developed, we can gather usability data on the system?s dialogue interaction and behaviors that can guide improvements to the speech interface. Prelimi-nary testing has shown promising results, suggesting that it is possible to test properties of dialogue separately from other factors such as recognition quality.
Do urinary mononuclear cells reflect disease activity in lupus nephritis? (2003)

Glomerular inflammation is associated with urinary mononuclear cells (UMC) in a number of diseases including IgA nephropathy and glomerulonephritis. We examined UMC from children with lupus nephritis for a number of years to characterize the types of mononuclear cells found in urine and to determine if they were associated with active lupus nephritis. Detailed analysis of UMC by cell counts and by flow cytometry showed that monocytes were the clearly dominant cell type. Evaluation of the smaller number of lymphocytes found in the urine of patients with active lupus nephritis demonstrated a strong predominance of CD8+ lymphocytes, in contrast to the normal CD4+/CD8+ ratio that is found in peripheral blood. The degree of proteinuria strongly correlated with the presence of UMC. The UMC counts decreased as their clinical condition improved as indicated by lower indices of flare. These observations suggest that UMC may be a valuable tool in detecting and monitoring disease activity in patients with severe lupus nephritis. More importantly, this study indicated that both monocytes and cytotoxic CD8+ T cells may play a role in pathogenesis of lupus nephritis.
Nonvenous Origin of Dermal Lymphatic Vasculature (2015)

Our results demonstrate a significant contribution of nonvenous-derived cells to the dermal lymphatic vasculature. Demonstration of a previously unknown lymphatic endothelial cell progenitor population will now allow further characterization of their origin, identity, and functions during normal lymphatic development and in pathology, as well as their potential therapeutic use for lymphatic regeneration.
Nano-scale photonic crystal microcavity characterization with an all-fiber based 1.2 - 2.0 ?m supercontinuum (2005)

The use of ultra-broadband supercontinuum generated by an all-fiber system to characterize high-index contrast photonic circuits over the wavelength range 1.2 - 2.0 microm is demonstrated. Efficient, broadband waveguide coupling techniques and sensitive normalized detection enable rapid and high-resolution measurements of nano-scale one-dimensional photonic crystal microcavities. Experimental mappings of bandgaps and cavity mode resonances with a wavelength resolution of 0.1 nm compare well with computer simulations.
Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly (2022)

For more than 100 years, the fruit fly <i>Drosophila melanogaster</i> has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula <i>Drosophilae</i>, that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types. We provide an in-depth analysis of cell type-related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal. Analysis of common cell types between tissues, such as blood and muscle cells, reveals rare cell types and tissue-specific subtypes. This atlas provides a valuable resource for the <i>Drosophila</i> community and serves as a reference to study genetic perturbations and disease models at single-cell resolution.
[Experimental optical impression in the CAD/CAM Dental Restorative System]. (1989)

A three dimensional measuring system was developed for the dental restorative CAD/CAM system. The equation of (formula; see text) was used for the computer simulation to demonstrate reproductibility of this measuring system, then actual measurements were also performed. The result from the simulation and from the measurement coincided, consequently it was concluded that the equation could explain the reproducibility of the system. Speckle and unwanted reflected light were found to be the main factors in restricting the range of good reproducibility. So new measuring systems based on the use of a two-beam interfere system were developed, which cancelled out the influence of these factors.
5.6-W linearly-polarized fiber laser at 1180 nm employing low-loss ytterbium-doped polarization maintaining solid photonic bandgap fiber (2010)

We have demonstrated an output power of 5.6 W at 1180 nm in linearly-polarized fiber laser using a low-loss ytterbium-doped polarization maintaining solid photonic bandgap fiber. A slope efficiency of 31 % has been achieved.
CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival (2013)

CD160 is a cell surface molecule expressed by most NK cells and approximately 50% of CD8(+) cytotoxic T lymphocytes. Engagement of CD160 by MHC class-I directly triggers a costimulatory signal to TCR-induced proliferation, cytokine production and cytotoxic effector functions. The role of CD160 in alloimmunity is unknown. Using a newly generated CD160 fusion protein (CD160Ig) we examined the role of the novel costimulatory molecule CD160 in mediating CD4(+) or CD8(+) T cell driven allograft rejection. CD160Ig inhibits alloreactive CD8(+) T cell proliferation and IFN-γ production in vitro, in particular in the absence of CD28 costimulation. Consequently CD160Ig prolongs fully mismatched cardiac allograft survival in CD4(-/-), CD28(-/-) knockout and CTLA4Ig treated WT recipients, but not in WT or CD8(-/-) knockout recipients. The prolonged cardiac allograft survival is associated with reduced alloreactive CD8(+) T cell proliferation, effector/memory responses and alloreactive IFN-γ production. Thus, CD160 signaling is particularly important in CD28-independent effector/memory CD8(+) alloreactive T cell activation in vivo and therefore may serve as a novel target for prevention of allograft rejection.
Three‐component photopolymers based on thermal crosslinking and acidolytic de‐crosslinking of vinyl ether groups. 2. effects of acid components on photopolymer characteristics (1995)

Abstract The three‐component photopolymers consisting of poly(p‐hydroxystyrene) (PHS) or poly(styrene‐co‐acrylic acid) (PSA) as the binder polymer, 2,2‐bis(4‐(2‐(vinyloxy)ethoxy)phenyl)propane (BPA‐DEVE) or 1,1,1‐tris(4‐(2‐(vinyloxy)ethoxy)phenyl)ethane (THPETEVE) as the crosslinking agent, and a photoacid generator were investigated with regard to their lithographic characteristics and thermal crosslinking reactivity because of the acidity of the acid component. The thermal crosslinking rate can be represented as the pseudo first‐order reaction. The PSA copolymer with an acrylic acid unit has the higher crosslinking rate and sensitivity, and the lower activation energy. Under low baking temperatures at which crosslinking does not take place, dual‐mode resist behavior is observed.
Synthesis of 3-Substituted Isoxazolecarboxamides as Potential Fungicides (2010)

A series of new 3-substituted isoxazolecarboxamides have been prepared from aldehydes. A key step was a 1,3-dipolar cycloaddition of nitrile oxides to α,β-unsaturated esters. Some of these compounds exhibited high fungicidal activities against Alternaria alternate, Botrytis cinerea, Rhizoctonia solani, Fusarium culmorum, and Phytophthora cactorum. Keywords: Chlorination, cycloaddition, fungicides, isoxazolecarboxamides, regioselectivity, synthesis, Alternaria alternate, Botrytis cinerea, Rhizoctonia solani, Fusarium culmorum, Phytophthora cactorum, flufenacet, isoxaben, pentanochlor, flutolani, Huisgen method, HRMS, NMR spectra, racemate, ESI mass spectra, Micromass LCT, Flash-chromatography, HMPA
Three-Dimensional Chip Stack With Integrated Decoupling Capacitors and Thru-Si Via Interconnects (2010)

In this letter, the integration of CMOS-compatible thru-Si via (TSV) interconnects with deep-trench decoupling capacitors is demonstrated. Reliability test is performed with a 65-nm CMOS test chip on top of a 3-D Si interposer chip that contains 10 000 TSV interconnects. Multilayer stacking is also demonstrated, and capacitance density of 280 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\hbox{nF/mm}^{2}$</tex></formula> is achieved with two-layer Si interposer chip stacks.
Fourier Policy Gradients (2018)

We propose a new way of deriving policy gradient updates for reinforcement learning. Our technique, based on Fourier analysis, recasts integrals that arise with expected policy gradients as convolutions and turns them into multiplications. The obtained analytical solutions allow us to capture the low variance benefits of EPG in a broad range of settings. For the critic, we treat trigonometric and radial basis functions, two function families with the universal approximation property. The choice of policy can be almost arbitrary, including mixtures or hybrid continuous-discrete probability distributions. Moreover, we derive a general family of sample-based estimators for stochastic policy gradients, which unifies existing results on sample-based approximation. We believe that this technique has the potential to shape the next generation of policy gradient approaches, powered by analytical results.
The intense slow positron beam facility at the PULSTAR reactor and applications in nano-materials study (2013)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Ming Liu, Jeremy Moxom, Ayman I. Hawari, David W. Gidley; The intense slow positron beam facility at the PULSTAR reactor and applications in nano-materials study. AIP Conf. Proc. 19 April 2013; 1525 (1): 455–459. https://doi.org/10.1063/1.4802370 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Troglitazone Inhibits Progesterone Production in Porcine Granulosa Cells**This work was supported by a grant from the Sankyo Corporation (to R.J.U. and A.G.) and NIH Grant RO1-CA45181 (to M.N.). (1998)

Troglitazone (a thiazolidinedione that improves insulin resistance) lowers elevated androgen concentrations in women with polycystic ovarian syndrome. In this study, we assessed the direct effects of troglitazone on steroidogenesis in porcine granulosa cells. Troglitazone inhibited progesterone production in a dose- and time-dependent manner (earliest effects at 4 h, maximum at 24 h) without affecting cell viability. Progesterone production was also inhibited by troglitazone in the presence of 25-hydroxycholesterol, indicating that the drug does not affect intracellular cholesterol transport. Troglitazone also inhibited FSH- and forskolin-stimulated progesterone secretion. The reduced progesterone production was accompanied by marked elevations of pregnenolone concentrations, suggesting inhibition of 3beta-hydroxysteroid dehydrogenase (3beta-HSD). The activity of 3beta-HSD in troglitazone-treated granulosa cells was decreased by more than 60%, compared with controls after 24 h. Troglitazone did not affect aromatase activity in porcine granulosa cells. In summary, troglitazone has direct effects on porcine granulosa cell steroidogenesis. The drug specifically inhibits 3beta-HSD activity, resulting in impaired progesterone production. The clinical relevance of this direct in vitro effect on steroidogenesis needs further investigation.
DHFR Coamplification of t-PA in DHFR + Bovine Endothelial Cells: In Vitro Characterization of the Purified Serine Protease (1988)

High-level expression of human tissue-type plasminogen activator was accomplished in endothelial cells by a novel approach to dihydrofolate reductase (DHFR) coamplification in DHFR+ cells. A tripartite mammalian expression vector coding for DHFR, neomycin phosphotransferase, and the t-PA gene was introduced into bovine endothelial cells by transfection and selection for G418 resistance. Upon methotrexate selection of these transformants, we obtained endothelial cells that had amplified the plasmid-encoded DHFR and t-PA genes. As a result, cell lines were isolated that efficiently produced t-PA (greater than 4 pg/cell.day). This t-PA was purified and compared with recombinant t-PA produced in Chinese hamster ovary cells. These two t-PA samples differed in carbohydrate composition, and amounts of 530 and 527 amino acid forms but had similar in vitro activity.
Distributed nano-Strain Sensing Based on Random Fiber Grating Array (2021)

A high precision distributed real time measurement for dynamic strain sensing in a chirped pulse phase optical time domain reflectometry (φ-OTDR) system based on random fiber grating array is experimentally demonstrated. The minimum detectable amplitude of dynamic strain is 52 nε with frequency of 1 Hz.
Abstract 18025: Systematic Screening is Necessary to Detect Post-operative Thrombosis and Evaluate Risk in Children Undergoing Cardiac Surgery: A Prospective Observational Study (2015)

Introduction: Postoperative thrombosis in children undergoing cardiac surgery with cardiopulmonary bypass (CPB) is a frequent, under-diagnosed and clinically detrimental complication. Methods: Pediatric patients were prospectively enrolled before surgery with CPB in an observational cohort study. Children &lt;1 year old and cyanotic patients were oversampled. All subjects had serial lab assessment of hemostatic status and standardized vascular ultrasound for surveillance of post-operative thrombosis. Eligible non-enrolled patients were retrospectively reviewed as concurrent controls without study surveillance. All imaging findings underwent blinded adjudication to confirm the presence and clinical importance of identified thrombi. Results: Of 400 enrolled patients (54% males, 55% &lt;1 year, 25% cyanotic), 398 (99%) completed the study, and 339 (85%) had protocol vascular ultrasound prior to or within 1 week of hospital discharge. Post-operative thrombosis was diagnosed in 99 study patients (25%) vs. 10% of the 1,019 control patients (p&lt;0.001). Clinical evaluation alone missed 59% of all postoperative thrombi and 20% of clinically important thrombi. Multivariable factors associated with higher odds of postoperative thrombosis in study patients included 4 factors reflective of reduced heparin sensitivity and/or anticoagulation levels during CPB (Table). Postoperative thrombosis was associated with longer ICU stay (5 vs. 2 days, p=0.008), longer hospital stay (6 vs. 10 days, p&lt;0.001), increased odds of reintervention or post-operation ECMO (OR: 2.7, p=0.005) and mortality (OR: 5.9, p=0.002). Conclusions: Given the poor performance of relying on clinical suspicion for detecting post-operative thrombosis, children &lt;1 year old undergoing surgery with CPB should be systematically screened for thrombosis post-operatively. Individualization of thromboprophylaxis should consider both preoperative clinical factors and heparin sensitivity.
Advanced channel access techniques (2008)

This chapter introduces some of the advanced channel access techniques in the 802.11 standard. In addition to, and built upon, the distributed channel access techniques described in Chapter 7, the 802.11 standard includes two centrally coordinated channel access techniques. The PCF was introduced in the original 802.11 specification and HCCA was introduced in the 802.11e amendment to support parameterized QoS and to fix some of the deficiencies in the PCF. The chapter then introduces new channel access techniques in the 802.11n amendment.
Segmentation of speckle images based on level-crossing statistics (1991)

When imaging is performed by using a coherent signal, the result is frequently a realization of the stochastic process known as speckle. The information sought from this process is often the mean value of its envelope or intensity at each point in the image plane. When only a single realization of the process is available, ergodicity is required within a sufficiently large region for accurate estimation of the mean. The identification of these regions is the segmentation problem that is addressed. The approach presented clips the speckle image at a constant threshold level and analyzes the resulting bilevel image based on the level-crossing statistics of the speckle process. An analysis of the level-crossing process leads to a decision rule for identifying or segmenting distinct regions of the image based on the sizes of the fades and the excursions in the clipped speckle. The measurement of these sizes is accomplished by using the morphological transformations of opening and closing. This new approach has been applied to computer-generated speckle images and may prove useful in laser, ultrasound, and radar imaging, in which speckle phenomena are manifest.
Abstract 1290: Actinomycin D enhanced immunotoxin RG7787 killing of cancer cells (2016)

Abstract Immunotoxins are recombinant fusion proteins that contain an antibody fragment directed against a tumor selective surface antigen attached to a protein toxin. RG7787 is a newly developed, mesothelin-targeted immunotoxin designed to be less immunogenic and better tolerated than the previous clinical candidate SS1P. The targeting moiety of RG7787 consists of a humanized anti-mesothelin Fab, while its effector moiety is a truncated portion of Pseudomonas exotoxin A (PE) consisting essentially only of the catalytic domain III fused via a furin cleavable linker to the Fab fragment. The domain III variant used in RG7787 contains mutations that silence all known human B-cell and some T-cell epitopes. RG7787 targets and kills mesothelin-positive tumor cells, which are prevalent in mesothelioma, ovarian, lung, and pancreatic cancers. Safety and immunogenicity of RG7787 are being assessed in these tumor indications in an ongoing phase I trial. In order to further enhance the anti-tumoral activity of RG7787, we screened for clinically used drugs that can synergize with RG7787 in vitro and/or in vivo. Actinomycin D (Act D) is a potent transcription inhibitor and is used for treating a variety of cancers, including gestational trophoblastic neoplasia, Wilms tumor, rhabdomyosarcoma, and Ewing's sarcoma. In this study we found that the combination of Act D with RG7787 greatly stimulated cell killing of mesothelin positive cell lines, such as KB31, KLM1, and Hay. The combination also produced complete regressions of KLM1 pancreatic tumor xenografts in mice. To investigate the mechanism of killing we used an apoptosis RNA array and found that both Act D and RG7787 stimulate apoptotic stress responsive genes including TNFα, TRAILR2 (DR5), NFκB, GAD45A and TP53. The combination also increased cleavage and activation of the pro-apoptotic proteins caspase-3, -9, and PARP. Taken together our data indicate that combining RG7787 and Act D reduces the threshold for activation of apoptosis in cancer cells. Citation Format: Xiu Fen Liu, Laiman Xiang, Marco Prunotto, Gerhard Niederfellner, Ira Pastan. Actinomycin D enhanced immunotoxin RG7787 killing of cancer cells. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1290.
Near-infrared fluorescent labeling of tissue transglutaminase substrates for imaging tumor boundaries (2008)

A novel strategy is developed to optically image tumor boundaries by cross-linking near-infrared fluorescent-labeled tissue transglutaminase substrates into tumor boundary tissue.