gebhart/patrepeval huggingface dataset:
RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases (2019)

Abstract RBM45 is a multifunctional RNA binding protein (RBP) found in cytoplasmic and nuclear inclusions in amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and Alzheimer’s disease (AD). While cytoplasmic RBM45 inclusions contain other disease-associated proteins, nuclear RBM45 inclusions are morphologically and biochemically distinct from previously described nuclear inclusion pathology in these diseases. To better understand nuclear RBM45 aggregation and inclusion formation, we evaluated the association of RBM45 with a variety of membraneless nuclear organelles, including nuclear speckles, Cajal bodies, and nuclear gems. Under basal conditions, RBM45 is diffusely distributed throughout the nucleus and does not localize to a specific nuclear organelle. During cellular stress, however, the nuclear RBM45 distribution undergoes an RNA-binding dependent rearrangement wherein RBM45 coalesces into a small number of nuclear puncta. These puncta contain the nuclear stress body (NSB) markers heat shock factor 1 (HSF1) and scaffold attachment factor B (SAFB). During chronic stress, the persistent association of RBM45 with NSBs leads to the formation of large, insoluble nuclear RBM45 inclusions. RBM45 nuclear inclusions persist after stressor removal and NSB disassembly and the inclusions resemble the nuclear RBM45 pathology seen in ALS, FTLD, and AD. We also quantified the cell type- and disease-specific patterns of RBM45 pathology in ALS, FTLD, AD, and non-neurologic disease control subjects. RBM45 nuclear and cytoplasmic inclusions are found in neurons and glia in ALS, FTLD, and AD but not in controls. Across diseases, RBM45 nuclear inclusion pathology occurs more frequently than cytoplasmic RBM45 inclusion pathology and exhibits cell type-specific variation. Collectively, our results define new stress-associated functions of RBM45, a mechanism for its nuclear aggregation and inclusion formation, a role for NSBs in the pathogenesis of diseases such as ALS, FTLD, and AD, and further underscore the importance of self-association to both the normal and pathological functions of RBPs in these diseases.
A1.4 Highly Sensitive Compact Room Temperature Quantum Scalar Magnetometer (2020)

Magnetometry with nitrogen–vacancy (NV) defects in diamond has been extensively stud-ied in the past [1]. While most approaches in-clude the use of microwaves (MW) for the de-tection of electron spin resonance, only few investigate the sensitivity of the photolumines-cence (PL) from NV centers to an external magnetic field without MW [2, 3, 4]. This work aims to utilize this effect to build a highly sensi-tive and compact room temperature magne-tometer. The avoidance of MW serves the re-duction of production costs and allows a com-mercialization at the current patent situation.
Comparison of Solute Nanoclusters in Fe–Cr–N Tempered Martensite Observed by Different Atom Probe Instruments (2022)

Abstract The solute clustering behaviors in Fe-1.0mass%Cr-0.3mass%N tempered martensite were comparatively studied by using three atom probe instruments, i.e. LEAP 4000 HR, 5000 XR, and 5000 XS. The microstructural features of nanoclusters were measured under the same conditions in voltage pulse mode, while statistical analysis including nearest neighbor distribution, radial distribution, frequency distribution, and cluster size distribution of Cr atoms were performed on the reconstructed datasets. The results revealed the superior capability of the LEAP 5000 XR to detect Cr nanoclusters in tempered martensite compared with the LEAP 4000 HR as a result of the improvement in detection efficiency and hit detection performance, whereas the high level of background in the mass-to-charge spectrum measured by the LEAP 5000 XS in voltage pulse mode limits its application in the detection of solute nanoclusters.
FORMOSAT-3/COSMIC Spacecraft Constellation System, Mission Results, and Prospect for Follow-On Mission (2009)

The FORMOSAT-3/COS MIC space craft con stel la tion con sist ing of six LEO sat el lites is the world's first op er a tional GPS Ra dio Occultation (RO) mis sion. The mis sion is jointly de vel oped by Tai wan's Na tional Space Or ga ni za tion (NSPO) and the United States' UCAR in col lab o ra tion with NSF, USAF, NOAA, NASA, NASA's Jet Pro pul sion Lab o ra tory, and the US Na val Re search Lab o ra tory. The FORMOSAT-3/COS MIC sat el lites were suc cess fully launched from Vandenberg US AFB in Cal i for nia at 0140 UTC 15 April 2006 into the same or bit plane of the des ig nated 516 km al ti tude. The mis sion goal is to de ploy the six sat el lites into six or bit planes at 800 km al ti tude with a 30-de gree sep a ra tion for evenly dis trib uted global cov er age. All six FORMOSAT-3/COS MIC sat el lites are cur rently main tain ing a sat is fac tory good state-of-health. Five out of six sat el lites have reached their fi nal mis sion or bit of 800 km as of No vem ber 2007. The data as re ceived by FORMOSAT-3/COS MIC sat el lites con stel la tion have been pro cessed in near real time into 2500 good ion o spheric pro files and 1800 good at mo spheric pro files per day. These have out num bered the world wide ra dio sondes (~900 mostly over land) launched from the ground per day. The pro cessed at mo spheric RO data have been as sim i lated into the Nu mer i cal Weather Pre dic tion (NWP) mod els for real-time weather pre dic tion and ty phoon/hur ri cane fore cast ing by many ma jor weather cen ters in the world. This pa per de scribes the FORMOSAT-3/COS MIC sat el lite con stel la tion sys tem per for mance and the mission results that span the period from April 2006 to October 2007; and reviews the prospect of a future follow-on mission.
A donor—crown—acceptor triad: the effect of cations included into the triad on the photo-induced electron-transfer rate (1991)

A donor—crown—acceptor triad, consisting of 1,7,10,16-tetraoxa-4,13-diazacyclooctadecane as a spacer, is designed as a new approach to the elucidation of the electronic effect of a spacer on intramolecular electron transfer between bridgehead chromophores.
Detection of Audio-Video Synchronization Errors Via Event Detection (2021)

We present a new method and a large-scale database to detect audio-video synchronization(A/V sync) errors in tennis videos. A deep network is trained to detect the visual signature of the tennis ball being hit by the racquet in the video stream. Another deep network is trained to detect the auditory signature of the same event in the audio stream. During evaluation, the audio stream is searched by the audio network for the audio event of the ball being hit. If the event is found in audio, the neighboring interval in video is searched for the corresponding visual signature. If the event is not found in the video stream but is found in the audio stream, A/V sync error is flagged. We developed a large-scaled database of 504,300 frames from 6 hours of videos of tennis events, simulated A/V sync errors, and found our method achieves high accuracy on the task.
ChemInform Abstract: NEW RING CLOSURES OF QUINAZOLINE DERIVATIVES BY HEXAMINE (1976)

Abstract Das Benzophenon (I) wird beim Erhitzen mit dem Ester (II) und Urotropin (Hexamin) in Methanol (IIIa) bzw. Äthanol (IIIb) zu den Dihydrochinazolinen (IVa) [Produktgemisch mit (IVa) (R: ‐H) als Nebenprodukt] bzw. (IVb) cyclisiert.
Performance Improvement of Wild Flower Boundary Extraction in Complex Background (2013)

The performance of an automatic system for extracting flower boundaries for ten different types of wild flowers has been improved. The proposed flower boundary extraction method consists of three major procedures: the detection of four edge points, boundary tracing and performance improvement part. The flower boundary extraction part involves a new technique for automatically identifying the boundary of a flower in an image. An Intelligent Scissor algorithm is applied for boundary tracing. The color gradient magnitude and Canny edge detection are analyzed and included as the cost terms of the Intelligent Scissor algorithm. The color gradient magnitude cost term is implemented so that it can act directly on the three components of the color image. For the third procedure, we implement performance improvement. The main advantage of the proposed method was that when the program detected the wrong four edge points, using the mouse the correct positions could be clicked. The proposed method was applied to 500 photos of 10 different flowers, with 50 photos of each flower all in a complex background. The experimental results showed an extraction rate of 79.4%, which was better than before.
Venturing into the unknown --- the making of "Frozen 2" (2020)

Why was Elsa born with magical powers? What truths about the past await her as she ventures beyond Arendelle? In Walt Disney Animation Studios' "Frozen 2," she travels through the enchanted forests and meets elemental spirits on her dangerous but remarkable journey.
Chemical Mechanism of DNA Cleavage by the Homing Endonuclease I-PpoI (1999)

Homing endonucleases are distinguished by their ability to catalyze the cleavage of double-stranded DNA with extremely high specificity. I-PpoI endonuclease, a homing endonuclease from the slime mold Physarum polycephalum, is a small enzyme (2 x 20 kDa) of known three-dimensional structure that catalyzes the cleavage of a long target DNA sequence (15 base pairs). Here, a detailed chemical mechanism for catalysis of DNA cleavage by I-PpoI endonuclease is proposed and tested by creating six variants in which active-site residues are replaced with alanine. The side chains of three residues (Arg61, His98, and Asn119) are found to be important for efficient catalysis of DNA cleavage. This finding is consistent with the proposed mechanism in which His98 abstracts a proton from an attacking water molecule bound by an adjacent phosphoryl oxygen, Arg61 and Asn119 stabilize the pentavalent transition state, and Asn119 also binds to the essential divalent metal cation (e.g., Mg(2+) ion), which interacts with the 3'-oxygen leaving group. Because Mg(2+) is required for cleavage of a substrate with a good leaving group (p-nitrophenolate), Mg(2+) likely stabilizes the pentavalent transition state. The pH-dependence of k(cat) for catalysis by I-PpoI reveals a macroscopic pK(a) of 8.4 for titratable groups that modulate product release. I-PpoI appears to be unique among known restriction endonucleases and homing endonucleases in its use of a histidine residue to activate the attacking water molecule for in-line displacement of the 3'-leaving group.
Domain Adaptation for Structured Output via Discriminative Patch\n Representations (2019)

Predicting structured outputs such as semantic segmentation relies on\nexpensive per-pixel annotations to learn supervised models like convolutional\nneural networks. However, models trained on one data domain may not generalize\nwell to other domains without annotations for model finetuning. To avoid the\nlabor-intensive process of annotation, we develop a domain adaptation method to\nadapt the source data to the unlabeled target domain. We propose to learn\ndiscriminative feature representations of patches in the source domain by\ndiscovering multiple modes of patch-wise output distribution through the\nconstruction of a clustered space. With such representations as guidance, we\nuse an adversarial learning scheme to push the feature representations of\ntarget patches in the clustered space closer to the distributions of source\npatches. In addition, we show that our framework is complementary to existing\ndomain adaptation techniques and achieves consistent improvements on semantic\nsegmentation. Extensive ablations and results are demonstrated on numerous\nbenchmark datasets with various settings, such as synthetic-to-real and\ncross-city scenarios.\n
Pten Inactivation Accelerates Oncogenic K-ras –Initiated Tumorigenesis in a Mouse Model of Lung Cancer (2008)

Phosphatase and tensin homologue deleted from chromosome 10 (Pten) is expressed aberrantly in non-small cell lung cancer cells, but the role of Pten in lung neoplasia has not been fully elucidated. In this study, we used a genetic approach to inactivate Pten in the bronchial epithelium of mice. Although, by itself, Pten inactivation had no discernible effect on bronchial epithelial histology, it accelerated lung tumorigenesis initiated by oncogenic K-ras, causing more rapid lethality than that induced by oncogenic K-ras alone (8 weeks versus 24 weeks of median duration of survival, respectively). Lung tumors arose in K-ras mutant, Pten-deficient mice that rapidly obstructed bronchial lumina and replaced alveolar spaces. Relative to K-ras mutant tumors, the K-ras mutant, Pten-deficient tumors exhibited more advanced histologic severity and more prominent inflammation and vascularity. Thus, Pten inactivation cooperated with oncogenic K-ras in promoting lung tumorigenesis.
Design of an ultra thin secondary lens for visible light communication based on a white LED (2009)

Light-emitting diodes (LEDs) have begun to penetrate the traditional lighting industry and have left a profound impact on the illumination of thin and portable personnel telecommunication devices. Aside from this, LEDs can also be used in the design of visible optical wireless communication systems. In lighting applications, surface mount device (SMD) LEDs play an important role; however, their low light flux brought about by the large viewing angle should be redistributed to increase luminescence and the communication range in communication applications. For this reason, the current study issue in this application is how to achieve a long data transmission range while dramatically reducing the overall system size for use in thin electronic products. This work presents a proposed design of an ultra-thin secondary lens for visible light communication based on white LEDs. The accurate physical modeling of a chip die and its package can make ray-trace simulation a powerful tool in predicting power distribution of the SMD LEDs in the near-field. To verify the proposed method, modeled ray data was compared with measured data. While relaxing several design constraints, the secondary light colliminator was carried out with a solution of a central refractive aspheric surface and an outer reflective surface. The optical performance of the modeled LEDs was very similar to the real one. The designed lens reduced the viewing angle of white SMD LEDs from 120deg to 20deg in FWHM. The proposed lens is extremely compact and efficient and is a good starting point in achieving an effective design of visible light communication between personnel telecommunication devices.
Fighting Antibiotic-Resistant Klebsiella pneumoniae with “Sweet” Immune Targets (2018)

Antibiotics and vaccines have greatly impacted human health in the last century by dramatically reducing the morbidity and mortality associated with infectious diseases. The recent challenge posed by the emergence of multidrug-resistant bacteria could possibly be addressed by novel immune prophylactic and therapeutic approaches. Among the newly threatening pathogens, <i>Klebsiella pneumoniae</i> is particularly worrisome in the nosocomial setting, and its surface polysaccharides are regarded as promising antigen candidates. The majority of <i>Klebsiella</i> carbapenem-resistant strains belong to the sequence type 158 (ST258) lineage, with two main clades expressing capsular polysaccharides CPS1 and CPS2. In a recent article, S. D. Kobayashi and colleagues (mBio 9:e00297-18, 2018, https://doi.org/10.1128/mBio.00297-18) show that CPS2-specific IgGs render ST258 clade 2 bacteria more sensitive to human serum and phagocytic killing. E. Diago-Navarro et al. (mBio 9:e00091-18, 2018, https://doi.org/10.1128/mBio.00091-18) generated two murine monoclonal antibodies recognizing distinct glycotopes of CPS2 that presented functional activity against multiple ST258 strains. These complementary studies represent a step toward the control of this dangerous pathogen.
Unexpected Corrosion of Type 316L Stainless Steel Neutralization Tanks (1992)

Abstract Although field corrosion tests had indicated that type 316L stainless steel would be a suitable material for neutralization tanks, the vessels suffered severe corrosion when placed in service. Welded coupons of type 316L had been tested along with similar Alloy 20Cb® (UNS NO8020) specimens in a lead-lined tank equipped with copper coils that had served in this function prior to construction of the new tanks. Both materials exhibited virtually no corrosion and no preferential weld attack. Type 316L was selected for the project. The subsequent corrosion was the result of the borderline passivity of type 316L in hot dilute sulfuric acid (about 0.1%). Inaccuracy of the testing was attributed to the presence of cupric ions in the lead-lined vessel fluids, which had been released by corrosion of the copper coils. Careful control of both temperature and pH was recommended to reduce the corrosion to an acceptable limit.
Microbial alignment in flow changes ocean light climate (2011)

The growth of microbial cultures in the laboratory often is assessed informally with a quick flick of the wrist: dense suspensions of microorganisms produce translucent "swirls" when agitated. Here, we rationalize the mechanism behind this phenomenon and show that the same process may affect the propagation of light through the upper ocean. Analogous to the shaken test tubes, the ocean can be characterized by intense fluid motion and abundant microorganisms. We demonstrate that the swirl patterns arise when elongated microorganisms align preferentially in the direction of fluid flow and alter light scattering. Using a combination of experiments and mathematical modeling, we find that this phenomenon can be recurrent under typical marine conditions. Moderate shear rates (0.1 s(-1)) can increase optical backscattering of natural microbial assemblages by more than 20%, and even small shear rates (0.001 s(-1)) can increase backscattering from blooms of large phytoplankton by more than 30%. These results imply that fluid flow, currently neglected in models of marine optics, may exert an important control on light propagation, influencing rates of global carbon fixation and how we estimate these rates via remote sensing.
Wide-Band Audio Coding Based on Frequency-Domain Linear Prediction (2010)

We revisit an original concept of speech coding in which the signal is separated into the carrier modulated by the signal envelope.A recently developed technique, called frequency-domain linear prediction (FDLP), is applied for the efficient estimation of the envelope.The processing in the temporal domain allows for a straightforward emulation of the forward temporal masking.This, combined with an efficient nonuniform sub-band decomposition and application of noise shaping in spectral domain instead of temporal domain (a technique to suppress artifacts in tonal audio signals), yields a codec that does not rely on the linear speech production model but rather uses well-accepted concept of frequency-selective auditory perception.As such, the codec is not only specific for coding speech but also well suited for coding other important acoustic signals such as music and mixed content.The quality of the proposed codec at 66 kbps is evaluated using objective and subjective quality assessments.The evaluation indicates competitive performance with the MPEG codecs operating at similar bit rates.
Balancing Programmability and Silicon Efficiency of Heterogeneous Multicore Architectures (2012)

Multicore architectures provide scalable performance with a lower hardware design effort than single core processors. Our article presents a design methodology and an embedded multicore architecture, focusing on reducing the software design complexity and boosting the performance density. First, we analyze characteristics of the Task-Level Parallelism in modern multimedia workloads. These characteristics are used to formulate requirements for the programming model. Then we translate the programming model requirements to an architecture specification, including a novel low-complexity implementation of cache coherence and a hardware synchronization unit. Our evaluation demonstrates that the novel coherence mechanism substantially simplifies hardware design, while reducing the performance by less than 18% relative to a complex snooping technique. Compared to a single processor core, the multicores have already proven to be more area- and energy-efficient. However, the multicore architectures in embedded systems still compete with highly efficient function-specific hardware accelerators. In this article we identify five architectural methods to boost performance density of multicores; microarchitectural downscaling, asymmetric multicore architectures, multithreading, generic accelerators, and conjoining. Then, we present a novel methodology to explore multicore design spaces, including the architectural methods improving the performance density. The methodology is based on a complex formula computing performances of heterogeneous multicore systems. Using this design space exploration methodology for HD and QuadHD H.264 video decoding, we estimate that the required areas of multicores in CMOS 45 nm are 2.5 mm 2 and 8.6 mm 2 , respectively. These results suggest that heterogeneous multicores are cost-effective for embedded applications and can provide a good programmability support.
Detecting Age-Related Macular Degeneration: Technologies Are Best Compared When Standardized (2005)

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