gebhart/patrepeval huggingface dataset:
Abstract 2689: Drivers of cancer cell invasion and metastasis. (2013)

Abstract Metastatic spread of cancer cells from their primary site requires invasion into the vasculature, evasion at the distant organ site and colonization of the distant organ. Here we studied mechanisms of attachment and invasion into endothelial monolayers by cancer cells to identify driver molecules and signaling pathways that are crucial for the invasive and metastatic phenotype. Different human and mouse cancer cell lines were transduced with lentiviral-based, genome-wide or kinome-targeted shRNA libraries. Cancer cell populations of different invasive and metastatic phenotype were then selected for their loss- or gain-of-function respectively in endothelial invasion in vitro or by tumor growth and metastasis selection in vivo. After several rounds of selection, the respective shRNA targeted genes were identified from the selected cancer cell populations or from clonal cell lines. Eighteen different genes targeted by two to four distinct shRNAs each were identified in the in vitro selection for endothelial attachment and invasion. The function of the genes as well as the clinical significance appear to explain their phenotypic selection. Citation Format: Ghada M. Sharif, Marcel O. Schmidt, Casey Shuptrine, Louis M. Weiner, Zhang-Zhi Hu, Anna T. Riegel, Anton Wellstein. Drivers of cancer cell invasion and metastasis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2689. doi:10.1158/1538-7445.AM2013-2689
Circuit characteristics of molecular electronic components (2004)

Electronic devices based on single molecules, or small assemblies of molecules, are attracting much attention as intrinsically nanoscale devices that can add functionality such as optical emission and nonvolatile storage to silicon-based electronics. One of the key issues in these devices is the nature of the microscopic contacts to the active molecules and the need to develop well-controlled interfaces in order to achieve low-resistance contacts. We describe the formation of suitable contact structures in the form of nanometer scale "break junctions" in gold lines, formed by lithographic or electrical means. The structure provides a lead frame for realizing high-quality contacts to nanometer-size molecules and nanoparticles with selective docking achieved by end-groups such as thiol (-SH). Metal-molecule-metal junctions can be formed by chemisorbing short molecules such as 1,4-benzenedithiol on the two electrodes. Current-voltage (I-V) characteristics have been measured for configurations including small numbers of molecules directly bonded in the junction and molecule/nanocluster/molecule assemblies. These junctions are being used as test beds to study electrical conduction through different types of engineered-molecules, and to subsequently develop circuit level models. By integrating these molecules with electrical contacts, selective microscopic events (e.g. doping events or gas docking) can be coupled to external circuitry.
The effect of squeeze film constriction on bandwidth improvement in interferometric accelerometers (2008)

This paper studies the effects of a constricted squeeze film on the performance of an optical microelectromechanical system accelerometer. Squeeze films are shown to extend the sensor frequency range (bandwidth) in accelerometers without decreasing the mechanical sensitivity by retarding the resonate response. By restricting the venting of a squeeze film, this preferential behavior is observed at lower frequencies than is expected for ideally vented accelerometers. Due to this effect, constricted squeeze films may be used to improve the bandwidth performance of devices of lower natural frequencies and higher inertial sensitivities. A model, extended from the existing squeeze film theory, is developed for the squeeze film formed between circular plates with generalized mixed boundary pressure conditions to describe the boundary flow resistance. These effects are experimentally observed in a parallel plate Fabry–Perot interferometric accelerometer through frequency response characterization at mechanical resonance under pressure variation. The analytical results for the constricted squeeze film are used to predict the performance gains due to the frequency-dependent squeeze film parameters. These results are experimentally confirmed by demonstrating improved bandwidth performance due to the constricted squeeze film.
DC bias analysis and small-signal characteristic of active-clamp forward-flyback DC-DC converter with a current doubler rectifier (2005)

The paper presents the steady-state and dynamic small-signal models for the active-clamp forward-flyback DC-DC converter with a current doubler rectifier. Based on the established models, several issues, such as inductor current sharing, transformer DC bias of magnetizing current and converter design, are discussed.
Machine Learning for Benchmarking Adolescent Idiopathic Scoliosis Surgery Outcomes (2023)

Classification of benchmark outcomes is improved with ensemble ML techniques and may provide much needed case-adjustment for a surgeon performance program. Precise estimates of health-related quality of life scores and continuous variables were not possible, suggesting that performance classification is a better method of performance evaluation.
A crown ether tetrathiafulvalene cage (1990)

J. Becher, T. K. Hansen, N. Malhotra, G. Bojesen, S. Bøwadt, K. S. Varma, B. Girmay, J. D. Kilburn and A. E. Underhill, J. Chem. Soc., Perkin Trans. 1, 1990, 175 DOI: 10.1039/P19900000175
Supplementary Table 1 from Exploiting the Mutanome for Tumor Vaccination (2023)

&lt;p&gt;XLS file - 15K&lt;/p&gt;
Force control including contact process using acceleration-sensor-based instantaneous state observer for high-stiffness gear drive (2016)

This paper proposes a force control system including contact process using acceleration-sensor-based instantaneous state observer for high-stiffness gear drive. The proposed system is structured by PI velocity control system and IP force control system based on resonance ratio control system. An instantaneous state observer is used to a resonance ratio control system for a high-stiffness gear drive. In proposed system, the robot arm of a high-stiffness gear drive is achieved to move closer to the environment by using PI velocity control system. Moreover, the robot arm is achieved to come in contact with the environment by using IP force control system. Additionally, the force control system including contact process is needed a smooth switching of these control system, and smooth force control. To achieve the smooth switching of control system, an initial value of an integrator of force control system is calculated by the condition that a motor-side torque reference is constant when switching the control system. In addition, the algorithm is proposed to achieve the smooth force control system. The proposed method is achieved the smooth switching of control system and smooth force control system. The effectiveness of proposed method is confirmed by numerical simulation and experiments.
Flow rate measurement using ultrasonic Doppler method with cavitation bubbles (2003)

The current principle of the flow velocity measurement method is based on the detection of the echoes of ultrasonic pulse Doppler method (UDM). However, in some applications, for example, a flow rate measurement in clean water, any particle does not exist in the flow and hence, the conventional UDM cannot be applied. The authors group proposed to employ the ultrasonic cavitation bubbles as reflectors in the flow measurement by UDM. The low frequency Langevin transducer attached to the outside wall of the pipe produces the cavitation bubbles in the flow. Therefore, UDM can be applied to the flow rate measurement without any suspending particle tracers. In this report, applicability and accuracy of the flow rate measurement are investigated in the case of the cavitations bubbles as reflectors. The measurement system with the cavitation production system is also designed and fabricated.
Association of antinuclear antibody seropositivity with inhaled environmental exposures in patients with interstitial lung disease (2021)

Patients with ILD and inhalational exposure had significantly higher prevalence of ANA-seropositivity than those without reported exposures across ILD diagnoses. Environmental and occupational exposures should be systematically reviewed in patients with ILD, particularly those with ANA-seropositivity.
Error correction of voicemail transcripts in SCANMail (2006)

Despite its widespread use, voicemail presents numerous usability challenges: People must listen to messages in their entirety, they cannot search by keywords, and audio files do not naturally support visual skimming. SCANMail overcomes these flaws by automatically generating text transcripts of voicemail messages and presenting them in an email-like interface. Transcripts facilitate quick browsing and permanent archive. However, errors from the automatic speech recognition (ASR) hinder the usefulness of the transcripts. The work presented here specifically addresses these problems by evaluating user-initiated error correction of transcripts. User studies of two editor interfaces-a grammar-assisted menu and simple replacement by typing-reveal reduced audio playback times and an emphasis on editing important words with the menu, suggesting its value in mobile environments where limited input capabilities are the norm and user privacy is essential. The study also adds to the scarce body of work on ASR confidence shading, suggesting that shading may be more helpful than previously reported.
Highly Stereoselective Hydroformylation of Olefins Possessing Chiral Sugar Templates (1998)

Hydroformylation of 1,1-disubstituted olefins possessing chiral sugar templates gave β-substituted aldehydes in good to excellent yields with up to 99% diastereoselectivity.
Study of high-p T charged particle suppression in PbPb compared to pp collisions at $\sqrt{s_{\mathrm{NN}}}=2.76~\mathrm{TeV}$ (2012)

The transverse momentum spectra of charged particles have been measured in pp and PbPb collisions at s NN = 2.76 TeV by the CMS experiment at the LHC. In the transverse momentum range p T = 5-10 GeV/c, the charged particle yield in the most central PbPb collisions is suppressed by up to a factor of 7 compared to the pp yield scaled by the number of incoherent nucleon-nucleon collisions. At higher p T , this suppression is significantly reduced, approaching roughly a factor of 2 for particles with p T in the range p T = 40-100 GeV/c.
Gonadotropin-Releasing Hormone Stimulates the Biosynthesis of Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate in the Hypothalamus (2013)

The sulfated neurosteroids pregnenolone sulfate (Δ(5)PS) and dehydroepiandrosterone sulfate (DHEAS) are known to play a role in the control of reproductive behavior. In the frog Pelophylax ridibundus, the enzyme hydroxysteroid sulfotransferase (HST), responsible for the biosynthesis of Δ(5)PS and DHEAS, is expressed in the magnocellular nucleus and the anterior preoptic area, two hypothalamic regions that are richly innervated by GnRH1-containing fibers. This observation suggests that GnRH1 may regulate the formation of sulfated neurosteroids to control sexual activity. Double labeling of frog brain slices with HST and GnRH1 antibodies revealed that GnRH1-immunoreactive fibers are located in close vicinity of HST-positive neurons. The cDNAs encoding 3 GnRH receptors (designated riGnRHR-1, -2, and -3) were cloned from the frog brain. RT-PCR analyses revealed that riGnRHR-1 is strongly expressed in the hypothalamus and the pituitary whereas riGnRHR-2 and -3 are primarily expressed in the brain. In situ hybridization histochemistry indicated that GnRHR-1 and GnRHR-3 mRNAs are particularly abundant in preoptic area and magnocellular nucleus whereas the concentration of GnRHR-2 mRNA in these 2 nuclei is much lower. Pulse-chase experiments using tritiated Δ(5)P and DHEA as steroid precursors, and 3'-phosphoadenosine 5'-phosphosulfate as a sulfonate moiety donor, showed that GnRH1 stimulates, in a dose-dependent manner, the biosynthesis of Δ(5)PS and DHEAS in frog diencephalic explants. Because Δ(5)PS and DHEAS, like GnRH, stimulate sexual activity, our data strongly suggest that some of the behavioral effects of GnRH could be mediated via the modulation of sulfated neurosteroid production.
1,5-Disubstituted Indazol-3-ols with Anti-Inflammatory Activity (1998)

A series of new indazol-3-ol derivatives was synthesized. Some of these compounds exhibit interesting anti-inflammatory activities in various models of inflammation. 5-Methoxy-1-[quinoline-2-yl-methoxy)-benzyl]-1H-indazol-3-ol (27) strongly inhibits the oxidation of arachidonic acid to 5-hydroperoxyeicosatetraenoic acid catalyzed by 5-lipoxygenase (IC50 = 44 nM). 27 also inhibits the contraction of sensitized guinea pig tracheal segments (IC50 = 2.9 microM). In guinea pigs treated with 27 (1 mg/kg i.p.) 2 h before antigen provocation, there was a marked inhibition (47%) of the antigen-induced airway eosinophilia. After topical application of 1 microgram/ear 27 inhibits the arachidonic acid induced mouse ear edema (41%).
Generation of High-Titer Neutralizing Antibodies against Botulinum Toxins A, B, and E by DNA Electrotransfer (2009)

Botulinum neurotoxins are known to be among the most toxic known substances. They produce severe paralysis by preventing the release of acetylcholine at the neuromuscular junction. Thus, new strategies for efficient production of safe and effective anti-botulinum neurotoxin antisera have been a high priority. Here we describe the use of DNA electrotransfer into the skeletal muscle to enhance antiserum titers against botulinum toxin serotypes A, B, and E in mice. We treated animals with codon-optimized plasmid DNA encoding the nontoxic but highly immunogenic C-terminal heavy chain fragment of the toxin. By employing both codon optimization and the electrotransfer procedure, the immune response and corresponding neutralizing antiserum titers were markedly increased. The cellular localization of the antigen and the immunization regimens were also shown to increase neutralizing titers to >100 IU/ml. This study demonstrates that DNA electrotransfer is an effective procedure for raising neutralizing antiserum titers to remarkably high levels.
Fully parallelized multi prover protocols for NEXP-time (2002)

A major open problem in the theory of multiprover protocols is to characterize the languages which can be accepted by fully parallelized protocols which achieve an exponentially low probability of cheating in a single round. The problem was motivated by the observation that the probability of cheating the n parallel executions of a multiprover protocol can be exponentially higher than the probability of cheating in n sequential executions of the same protocol. The problem is solved by proving that any language in NEXP-time has a fully parallelized multiprover protocol. By combining this result with a fully parallelized version of the protocol of M. Ben-Or et al. (ACM Symp. on Theory of Computing, 1988), a one-round perfect zero-knowledge protocol (under no cryptographic assumptions) can be obtained for every NEXPTIME language.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Development of augmented forward collision warning system for Head-Up Display (2014)

In this paper, we present an augmented forward collision warning system for Head-Up Display (HUD). The convergence of HUD and Augmented Reality (AR) needs challenge and make innovative application in automobile industry. We focus on an advance of Forward Collision Warning System (FCWS) by the fusion of HUD and AR. The proposed system detects the frontal vehicles and pedestrians, assesses the imminent danger caused by the detected results, and alerts the augmented warnings to support safe driving practices.
Rapid prototyping of lab-scale electrolysis cells using stereolithography and electroless plating (2023)

Electrolysis research is typically conducted using commercially available cells with standard designs that are difficult to modify or custom-machined parts that are time-consuming to produce. Here, we describe a method to rapidly produce lab-scale electrolysis cells that uses high-resolution, high-fidelity stereolithography 3D printing combined with electroless metal plating. Cells prepared by the printing/electroless plating method were compared with the same cells machined in Ti for CO electrolysis experiments. The printed cells showed performance very similar to that of the machined cells across a wide current density range (up to 250 mA cm−2) and demonstrated 24 h of stable operation in a zero-gap configuration. This work demonstrates the ability to prototype electrochemical cell designs in a fraction of the time required using conventional machining.
Feasibility of GaN-based room temperature THz laser in a spoof plasmon waveguide (2014)

We propose and study the feasibility of a THz GaN/AlGaN quantum cascade laser (QCL) consisting of only five periods with confinement provided by a spoof surface plasmon (SSP) waveguide for room temperature operation. The QCL design takes advantages of the large optical phonon energy and the ultrafast phonon scattering in GaN that allow for engineering favorable laser state lifetimes, and the SSP waveguide provides the optical confinement for the ultrathin QCL. Our analysis has shown that the waveguide loss is sufficiently low for the QCL to reach its threshold at the injection current density around 6 kA/cm<sup>2</sup> at room temperature.
Spatial Effects of Livestock Farming on Human Infections With Shiga Toxin‐Producing Escherichia coli O157 in Small but Densely Populated Regions: The Case of the Netherlands (2020)

The role of environmental transmission of typically foodborne pathogens like Shiga toxin-producing <i>Escherichia coli</i> (STEC) O157 is increasingly recognized. To gain more insights into spatially restricted risk factors that play a role in this transmission, we assessed the spatial association between sporadic STEC O157 human infections and the exposure to livestock (i.e. small ruminants, cattle, poultry, and pigs) in a densely populated country: the Netherlands. This was done for the years 2007-2016, using a state-of-the-art spatial analysis method in which hexagonal areas with different sizes (90, 50, 25 and 10 km<sup>2</sup>) were used in combination with a novel probability of exposure metric: the population-weighted number of animals per hexagon. To identify risk factors for STEC O157 infections and their population attributable fraction (PAF), a spatial regression model was fitted using integrated nested Laplace approximation (INLA). Living in hexagonal areas of 25, 50 and 90 km<sup>2</sup> with twice as much population-weighted small ruminants was associated with an increase of the incidence rate of human STEC O157 infections in summer (RR of 1.09 [95%CI;1.01-1.17], RR of 1.17 [95%CI;1.07-1.28] and RR of 1.13 [95%CI;1.01-1.26]), with a PAF of 49% (95%CI;8-72%). Results suggest exposure to small ruminants to be a risk factor, although no evidence on the mode of transmission is provided. Therefore, the underlying mechanisms warrant further investigation and could offer new targets for control. The newly proposed exposure metric has potential to improve existing spatial modeling studies on infectious diseases related to livestock exposure, especially in densely populated countries like the Netherlands.
Wave-front sensing by use of a Green’s function solution to the intensity transport equation (2003)

A method for reconstructing an unknown wave front from measurements of its intensity distribution on two planes along the direction of propagation is described. The method solves the intensity transport equation by use of Neumann boundary conditions, leading to a solution that requires only matrix multiplication. The method provides real-time wave-front reconstruction with high accuracy and is easily reposed to permit reconstruction of the wave front in any orthonormal basis set.
Optimal solid state neurons (2019)

Bioelectronic medicine is driving the need for neuromorphic microcircuits that integrate raw nervous stimuli and respond identically to biological neurons. However, designing such circuits remains a challenge. Here we estimate the parameters of highly nonlinear conductance models and derive the ab initio equations of intracellular currents and membrane voltages embodied in analog solid-state electronics. By configuring individual ion channels of solid-state neurons with parameters estimated from large-scale assimilation of electrophysiological recordings, we successfully transfer the complete dynamics of hippocampal and respiratory neurons in silico. The solid-state neurons are found to respond nearly identically to biological neurons under stimulation by a wide range of current injection protocols. The optimization of nonlinear models demonstrates a powerful method for programming analog electronic circuits. This approach offers a route for repairing diseased biocircuits and emulating their function with biomedical implants that can adapt to biofeedback.
Alpha-1-Antichymotrypsin in Renal Biopsies (1990)

Alpha 1-Antichymotrypsin (alpha 1-AK) and alpha-1-antitrypsin (alpha 1-AT) represent a defense mechanism to protect the tissues from proteolytic enzyme activity. We studied the implication of alpha 1-AK and alpha 1-AT in glomeruli of patients with different nephropathies based on the analysis of 52 paraffin-embedded renal biopsies with alpha 1-AK and alpha 1-AT antisera. The results demonstrate an intense alpha 1-AK glomerular staining in renal biopsies from patients with minimal-change disease, while a minor staining of this protein was found in the other nephropathies. No significant evidence of alpha 1-AT deposits was observed in our cases. Our findings suggest that when alpha 1-AK is lacking in glomeruli the defense mechanisms against proteolytic enzymes may not be efficient enough to protect the glomerular structures and limit the damage. Since alpha 1-AK is a reactant of the acute phase of inflammation, it may be considered as a marker of activity for monocyte-macrophages in glomerular damage.
Accurate cross-sectional stress profiling of optical fibers (2009)

A novel technique for determining two-dimensional, cross-sectional stress distributions in optical fibers and fiber-based devices is presented. Use of the Brace-Köhler compensator technique and a polarization microscope for the measurement of retardation due to stress-induced birefringence is described, along with the tomographic reconstruction process for the determination of stress. Measurements are performed on Corning SMF-28 fiber in an unperturbed section, a section near a cleaved end-face, and a section exposed to CO2 laser radiation. Cross-sectional stress distributions are presented. Stress relaxation is quantified in the cleaved fiber and the fiber exposed to CO2 laser radiation.