gebhart/patrepeval huggingface dataset:
Evaluation of an anther culture - derived doubled haploid population for RFLP mapping (1989)

Les auteurs estiment en conclusion de leur étude qu'une population haplodoublée dérivée de culture d'anthères à partir de croisement entre parents génétiquement éloignés offre une solution prometteuse autre que la population F2 trangréssive utilisée jusqu'ici pour la cartographie moléculaire du riz. En dépit d'évènements imprévisibles tels que l'hétérozygotie partielle et l'apparition d'allèles non-parentaux dans de rares lignées, aussi bien que des rapports de ségrégation biaisés à quelques locus, ces particularités liées à l'androgénèse ne constituent en rien des facteurs limitants en ce qui concerne la cartographie. C'est plutôt le degré de polymorphisme détecté entre les parents (spécifiques), APURA et IRAT 177 et la distribution des marqueurs mono et polymorphiques le long des chromosomes qui sont les traits particuliers de cette population haplodoublée, ce qui rend contestable sa valeur comme population permanente pour établir les cartes moléculaires
Designing optimal quantum detectors via semidefinite programming (2003)

We consider the problem of designing an optimal quantum detector to minimize the probability of a detection error when distinguishing among a collection of quantum states, represented by a set of density operators. We show that the design of the optimal detector can be formulated as a semidefinite programming problem. Based on this formulation, we derive a set of necessary and sufficient conditions for an optimal quantum measurement. We then show that the optimal measurement can be found by solving a standard (convex) semidefinite program. By exploiting the many well-known algorithms for solving semidefinite programs, which are guaranteed to converge to the global optimum, the optimal measurement can be computed very efficiently in polynomial time within any desired accuracy. Using the semidefinite programming formulation, we also show that the rank of each optimal measurement operator is no larger than the rank of the corresponding density operator. In particular, if the quantum state ensemble is a pure-state ensemble consisting of (not necessarily independent) rank-one density operators, then we show that the optimal measurement is a pure-state measurement consisting of rank-one measurement operators.
Aerogel Supported Nanoparticles in Catalysis (2007)

This chapter contains sections titled: Introduction Aerogel Nanocomposites as Catalysts of Important Reactions in Gaseous Media Fischer–Tropsch Synthesis Steam Reforming Oxidation Processes Oxidation of Carbon Monoxide Methanol Oxidation n-Butane Oxidation Volatile Organic Compounds Oxidation Dehydrochlorination of Chlorinated Volatile Organic Compounds Oxygen Reduction Reaction Cyclohexene Hydrogenation Isomerization of 1-Butene Aerogel Nanocomposites as Catalysts of Important Reactions in Liquid Media Oxidation of Olefins Dihydroxylation of Olefins Epoxidation of Olefins Claisen–Schmidt Condensation Mizoroki–Heck C–C Coupling Reactions Hydrocarbonylation of Aryl Halides Michael Additions Synthesis of Carbon Nanotubes
Recurrent neural network training by nprKF joint estimation (2003)

We present a method for training recurrent networks with the joint estimation of states and parameters, using the "derivative-free" formulation for nonlinear Kalman filters by Norgaard, Poulsen, and Ravn (2000). Our approach is consistent with that described by Williams (1992) for the extended Kalman filter (EKF). We extend the treatment to handle multistream training and propose ways of making the required computation more efficient.
Central Nervous System Cryptococcosis in Solid Organ Transplant Recipients: Clinical Relevance of Abnormal Neuroimaging Findings (2008)

Despite a higher antigen titer with meningeal lesions, outcomes tended to be worse with parenchymal compared with meningeal lesions or hydrocephalus. New onset CNS lesions may represent immune reconstitution syndrome and seemed to be associated with better outcome.
Perfusion of Endothelial Capillary Structure in Tissue Engineered Constructs by In Vitro Inosculation (2007)

In the present study we wanted to prove controlled perfusion of endothelial cells capillary channels in a collagen/chitosan/glycosaminoglycan (CCGAG) biopolymer inosculated on to a microfabricated device. This connection between a microfluidic structure, with one inlet and one outlet, and a tissue engineered construct made from human fibroblasts and umbilical vein endothelial cells should allow the generation of flow inside capillaries spontaneously created by endothelial cells within the biopolymer. We used many soft lithographic techniques to create the polycaprolactone‐poly (DL‐lactide‐co‐glycolide) acid microfluidic structure. The biopolymer is made by freeze‐drying the CCGAG solution, and then cells are seeded and cultured for a total of 31 days. Then the microfluidic structure and the biopolymer are cultured together in a bioreactor where degradation of the top layer of the microfluidic device allows inosculation in this model. We have shown such an inosculation phenomenon in our model by injecting fluorescent microspheres in the microfluidic device, separated the biopolymer from the device and performed confocal microscopy study on 30um thick cryostat sliced sample. Those are promising results for various applications such as tissue engineered vascularized organ substitutes and in vitro pharmacodynamics and angiogenesis studies. Financial support (NRC‐CIHR grant 66473)
Synthesis and Biological Evaluation of a 5-6-5 Imidazole-Phenyl-Thiazole Based α-Helix Mimetic (2008)

The development of small molecules that disrupt protein-protein interactions is a key goal in addressing a number of disease states. The alpha-helix is commonly found at protein interaction interfaces and has been the focus of substantial small molecule mimetic efforts. One of the primary drawbacks of many small molecule alpha-helix mimetics is their hydrophobic core structures. To address this problem we have developed a novel scaffold based on a more water soluble 5-6-5 imidazole-phenyl-thiazole core. An inhibitor of this class has been shown to disrupt the Cdc42/Dbs protein-protein interaction at micromolar concentrations and may be useful in overcoming Cdc42-induced tumor resistance to anticancer therapies.
Organic Light-Emitting Bistable Memory Devices with Self-Assembled Organic Nanoparticles as a Charge Trapping Center (2010)

Organic bistable memory devices were demonstrated by applying poly(styrene sulfonate)-doped poly(3,4-ethylene dioxythiopen) (PEDOT:PSS) as a self-organized charge trapping center inside a poly(9,9-dioctylfluorene) (PFO). PEDOT:PSS was introduced as nanoparticles by the chemical surface energy difference between PFO and PEDOT:PSS. The PEDOT:PSS nanoparticles played a role of the charge trapping center and an average on/off ratio around 100 was observed at a reading voltage of −2 V. The combination of PEDOT:PSS nanoparticle and LiF/Al cathode resulted in organic light-emitting bistable devices with a stable bistability and light-emitting performances.
Pharmacokinetic Analysis of Antibiotic Adsorption (Vancomycin and Teicoplanin) by the Lixelle Extracorporeal Unit (2015)

A VAN adsorption plateau indicating the VAN loading dose may be required in patients receiving DHP with the Lixelle S-35. The total TEC mass was adsorbed subsequent to 60 min of circulation, so the loading dose should be closely considered. In addition, the Lixelle S-35 may represent an option as a rescue therapy in accidental overdose of TEC.
Elastic fields of quantum dots in subsurface layers (2001)

In this work, models based on conventional small-strain elasticity theory are developed to evaluate the stress fields in the vicinity of a quantum dot or an ordered array of quantum dots. The models are based on three different approaches for solving the elastic boundary value problem of a misfitting inclusion embedded in a semi-infinite space. The first method treats the quantum dot as a point source of dilatation. In the second approach we approximate the dot as a misfitting oblate spheroid, for which exact analytic solutions are available. Finally, the finite element method is used to study complex, but realistic, quantum dot configurations such as cuboids and truncated pyramids. We evaluate these three levels of approximation by comparing the hydrostatic stress component near a single dot and an ordered array of dots in the presence of a free surface, and find very good agreement except in the immediate vicinity of an individual quantum dot.
The molecular recognition of phosphorylated proteins by designed polypeptides conjugated to a small molecule that binds phosphate (2011)

The conjugation of polypeptides from a designed set to the small molecule ligand 3,5-bis[[bis(2-pyridylmethyl)amino]methyl]benzoic acid, which in the presence of Zn(2+) ions binds inorganic phosphate, has been shown to provide a polypeptide conjugate that binds α-casein, a multiply phosphorylated protein, with a dissociation constant K(D) of 17 nM. The measured affinity is more than three orders of magnitude higher than that of the small molecule ligand for phosphate and the binding of 500 nM of α-casein was not inhibited by 10 mM phosphate buffer, providing a 2000-fold excess of phosphate ion over protein. The selectivity for phosphoproteins was demonstrated by extraction of α-casein from solutions of various complexity, including milk and human serum spiked with α-casein. In addition to α-casein, β-casein was also recognized but not ovoalbumin. Conjugation of a polypeptide to the zinc chelating ligand was therefore shown to give rise to dramatically increased affinity and also increased selectivity. A set of polypeptide conjugates is expected to be able to capture a large number of phosphorylated proteins, perhaps all, and in combination with electrophoresis or mass spectrometry become a powerful tool for the monitoring of phosphorylation levels. The presented binder can easily be attached to various types of surfaces; here demonstrated for the case of polystyrene particles. The example of phosphoproteins was selected since posttranslational phosphorylation is of fundamental importance in cell biology due to its role in signaling and therefore of great interest in drug development. The reported concept for binder development is, however, quite general and high-affinity binders can conveniently be developed for a variety of proteins including those with posttranslational modifications for which small molecule recognition elements are available.
Cognitive impairment associated with locomotive syndrome in community-dwelling elderly women in Japan (2017)

In our worldwide aging society, elderly people should maintain cognitive and physical function to help avoid health problems. Dementia is a major brain disease among elderly people, and is caused by cognitive impairment. The locomotive syndrome (LS) refers to a condition in which people require healthcare services because of problems associated with locomotion. The purpose of this study was to determine the association between cognitive impairment and LS. Study participants were 142 healthy elderly female volunteers living in a rural area in Japan. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). A score of ≤26 points on the MMSE was used to indicate categorically defined poor cognitive performance (cognitive impairment). The LS was defined by a score ≥16 points, and non-LS as <16 points, on the 25-question Geriatric Locomotive Function Scale (GLFS-25). Twenty-one participants (14.8%) had an MMSE score ≤26, and 19.0% were found to have LS. Compared with the MMSE >26 group, the ≤26 group was significantly older, had a higher percentage of body fat, and a higher GLFS-25 score. Those with LS were significantly older, had a higher body mass index, a higher percentage of body fat, and a lower MMSE score. Participants in the LS group had higher odds of cognitive impairment than those without LS [odds ratio (OR) =3.08] by logistic regression analysis adjusted for age. Furthermore, participants with GLFS-25 scores ≥6 had higher odds of cognitive impairment than those with a GLFS-25 score <6 by logistic regression analysis adjusted for both age (OR =4.44), and age and percent body fat (OR =4.12). These findings suggest that a strong relationship exists between the early stage of decreased motor function and cognitive impairment.
Anilide Derivatives of an 8-Phenylxanthine Carboxylic Congener Are Highly Potent and Selective Antagonists at Human A2B Adenosine Receptors (2000)

No highly selective antagonists of the A(2B) adenosine receptor (AR) have been reported; however such antagonists have therapeutic potential as antiasthmatic agents. Here we report the synthesis of potent and selective A(2B) receptor antagonists. The structure-activity relationships (SAR) of 8-phenyl-1, 3-di-(n-propyl)xanthine derivatives in binding to recombinant human A(2B) ARs in HEK-293 cells (HEK-A(2B)) and at other AR subtypes were explored. Various amide derivatives of 8-[4-[[carboxymethyl]oxy]phenyl]-1,3-di-(n-propyl)xanthine, 4a, were synthesized. A comparison of aryl, alkyl, and aralkyl amides demonstrated that simple anilides, particularly those substituted in the para-position with electron-withdrawing groups, such as nitro, cyano, and acetyl, bind selectively to human A(2B) receptors in the range of 1-3 nM. The unsubstituted anilide 12 had a K(i) value at A(2B) receptors of 1.48 nM but was only moderately selective versus human A(1)/A(2A) receptors and nonselective versus rat A(1) receptors. Highly potent and selective A(2B) antagonists were a p-aminoacetophenone derivative 20 (K(i) value 1.39 nM) and ap-cyanoanilide 27 (K(i) value 1.97 nM). Compound 27 was 400-, 245-, and 123-fold selective for human A(2B) receptors versus human A(1)/A(2A)/A(3) receptors, respectively, and 8.5- and 310-fold selective versus rat A(1)/A(2A) receptors, respectively. Substitution of the 1,3-dipropyl groups with 1,3-diethyl offered no disadvantage for selectivity, and high affinities at A(2B) receptors were maintained. Substitution of the p-carboxymethyloxy group of 4a and its amides with acrylic acid decreased affinity at A(2B) receptors while increasing affinity at A(1) receptors. 1, 3-Di(cyclohexylmethyl) groups greatly reduced affinity at ARs, although the p-carboxymethyloxy derivative 9 was moderately selective for A(2B) receptors. Several selective A(2B) antagonists inhibited NECA-stimulated calcium mobilization in HEK-A(2B) cells.
Quantum confinement of Bi2S3 in glass with magnetic behavior (2013)

The novel Bi2S3 quantum dots (QDs) glass nanosystems with unique magnetic properties have been investigated. The monodispersed QDs of size in the range of 3 to 15 nm were grown in the glass matrix. The optical study of these nanosystems clearly demonstrated the size quantization effect resulting in a pronounced band gap variation with QD size. The magnetic properties of the pristine glass and the Bi2S3 QD glass nanosystems were investigated by VSM and SQUID magnetometer. The pristine glass did not show any ferromagnetism while the Bi2S3 glass nanosystems showed significant and reproducible ferromagnetism. We also investigated the effect of the size of Bi2S3 QDs on the magnetic properties. The saturation magnetization for the 15 nm QD glass-nanosystem (124 memu/g) was observed to be higher as compared to the 3nm QD glass nanosystem (58.2 memu/g). The SQUID measurement gave the excellent hysteresis up to 300K. Surprisingly, the bulk Bi2S3 powder is diamagnetic in nature but Bi2S3 quantum dots glass nanosystem showed the ferromagnetic behavior for the first time. The investigated novel QD glass-nanosystem may have a potential application in spintronic devices and most importantly, this nanosystem can be fabricated in any usable shape as per the device requirement.
Resistant starch content in different types of rice in response to a range of cooking and cooling conditions (2005)

This in vitro study was carried out to test changes in the RS content of rice types dit1ering in their amylose-to-amylopectin content following various processing and cooling combinations. The hypotheses tested were: 1) rice variety will influence the RS content; 2) extrusion cooking will decrease RS content and; 3) cooking and cooling will increase the RS content.
ChemInform Abstract: Convenient Preparation of Optically Pure 3‐Aryloxy‐pyrrolidines. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
RECENT PROGRESS ON GaN-BASED ELECTRON DEVICES (2006)

We present results of some novel AlGaN/GaN heterojunction field-effect transistors (HFETs) specifically developed for RF front-end and power applications. To reduce the parasitic resistance, two unique techniques: selective Si doping into contact area and a superlattice (SL) cap structure, are developed. With the selective Si doping method, a transistor with an on-state resistance as low as 1.86 Ω·mm and a Tx/Rx switch IC with very low insertion loss (0.26 dB) and very high power handling capability (P1dB over 40 dBm) were obtained. With the SL cap HFETs, an ultra low source resistance of 0.4 Ω·mm was achieved and excellent DC and RF performances were demonstrated. The typical characteristics of these HFETs are: maximum transconductance of over 400 mS/mm, maximum drain current of 1.2 A/mm, cut-off frequency of 60 GHz, maximum oscillation frequency of 140 GHz, and a very low noise figure of 0.7 dB with 15 dB gain at 12 GHz. For power applications, in order to significantly reduce fabrication cost, we fabricated the AlGaN/GaN HFET on a conductive Si substrate with a source-via grounding (SVG) structure. The device has a very low on-state sheet resistance of 1.9 mΩ·cm 2 , a high off-state breakdown voltage of 350 V, and a current handling capability of 150 A. In addition, a sub-nano second switching response with t r of 98 ps and t f of 96 ps with a current density as high as 2.0 kA/cm 2 is demonstrated for the first time.
Prevalence of hepatitis C infection and risk factors in hospitalized diabetic patients: results of a cross-sectional study (2008)

A nosocomial source of HCV infection in hospitalized diabetic patients is suggested by the increased risk of HCV infection associated with the number of hospitalizations. This may account for at least 36% of cases of HCV infection.
Intravenous Calcium as a Pressor in a Swine Model of Hypoxic Lifeless Shock (2020)

Abstract Background: Resuscitation from hypoxic lifeless shock (LS, previously called pseudo-PEA) is often associated with hypotension refractory to catecholamine pressors. We hypothesized that this post-resuscitation state may be associated with hypocalcemia and the hypotension responsive to intravenous calcium. Results: Using pre-existing data from our hypoxic swine LS model, we measured blood pressure, hemodynamics, and electrolytes. In 9 animals with refractory hypotension we administered 37 boluses of intravenous calcium in the dosage range of 5 -20 mg. Physiological data were analyzed on a heartbeat by heartbeat basis. The midpoint of the calcium response was defined using change of curvature feature detection. Hemodynamic parameters were shifted such that the value at the midpoint was equal to zero. Comparisons were made between the average values in the time period 40-35 seconds before the bolus and 35-40 seconds after the bolus. Of the 37 administered boluses, 34 manifested a reaction in the blood pressure, with mean aortic pressure, systolic and diastolic pressures all increasing post bolus administration. Conclusions: Ionized hypocalcemia and hypotension may be common after resuscitation from hypoxic lifeless shock. Administration of intravenous calcium may be associated with a pressor-like response. Hypocalcemia is an etiology for hypotension, and intravenous calcium as a therapy in this setting should be further investigated.
Pricing Mechanisms for Crowd-Sensed Spatial-Statistics-Based Radio Mapping (2017)

Networking on white spaces (i.e., locally unused spectrum) relies on active monitoring of spectrum usage. Spectrum databases based on empirical radio propagation models are widely adopted but shown to be error-prone, since they do not account for built environments (e.g., trees and man-made buildings). As an alternative, crowd-sensed radio mapping by mobile clients who acquire local spectrum data and transmit it to a central aggregator (platform) for processing, results in more accurate radio maps. Success of such crowd-sensing systems presumes some incentive mechanisms to attract user participation. In this paper, we assume that the platform who constructs radio environment maps makes one-time offers (the incentive for participation) to users, and collects data from those who accept the offers. We design pricing mechanisms based on expected utility (EU) maximization, where EU captures the tradeoff between radio mapping performance (location and data quality), crowdsensing cost, and uncertainty in offer outcomes (i.e., possible expiration and rejection). Specifically, we consider both sequential offering, where one best price offer is sent to the best user in each round, and batched offering, where a batch of offers is made in each round. For the later, we show that EU is submodular in the discrete domain, and propose a mechanism that first fixes the pricing rule, and selects users based on unconstrained submodular maximization (USM); it then compares different pricing rules to find the best batch of offers in each round. We show that USM-based user selection has provable performance guarantee. Proposed mechanisms are evaluated and compared against utility-maximization-based baseline mechanisms.
Intranasal Immunization with RecombinantLactococcus lactisSecreting Murine Interleukin-12 Enhances Antigen-Specific Th1 Cytokine Production (2003)

Interleukin-12 (IL-12), a heterodimeric cytokine, plays an important role in cellular immunity to several bacterial, viral, and parasitic infections and has adjuvant activity when it is codelivered with DNA vaccines. IL-12 has also been used with success in cancer immunotherapy treatments. However, systemic IL-12 therapy has been limited by high levels of toxicity. We describe here inducible expression and secretion of IL-12 in the food-grade lactic acid bacterium Lactococcus lactis. IL-12 was expressed as two separate polypeptides (p35-p40) or as a single recombinant polypeptide (scIL-12). The biological activity of IL-12 produced by the recombinant L. lactis strain was confirmed in vitro by its ability to induce gamma interferon (IFN-gamma) production by mouse splenocytes. Local administration of IL-12-producing strains at the intranasal mucosal surface resulted in IFN-gamma production in mice. The activity was greater with the single polypeptide scIL-12. An antigen-specific cellular response (i.e., secretion of Th1 cytokines, IL-2, and IFN-gamma) elicited by a recombinant L. lactis strain displaying a cell wall-anchored human papillomavirus type 16 E7 antigen was dramatically increased by coadministration with an L. lactis strain secreting IL-12 protein. Our data show that IL-12 is produced and secreted in an active form by L. lactis and that the strategy which we describe can be used to enhance an antigen-specific immune response and to stimulate local mucosal immunity.
Feasibility of wireless gas detection with an FMCW RADAR interrogation of passive RF gas sensor (2010)

The feasibility of the remote measurement of gas detection from an RF gas sensor has been experimentally investigated. It consists of a Frequency-Modulated Continuous-Wave (FMCW) RADAR interrogation of an antenna loaded by the passive sensor. The frequency band of the RADAR [28.8-31GHz] allows the detection of the resonant frequencies of Whispering Gallery Modes that are sensitive to gas concentration. Reported experimental results provide the proof-of-concept of remote measurement of gas concentration fluctuation from RADAR interrogation of this new generation of passive gas sensors.