gebhart/patrepeval huggingface dataset:
Morbid Obesity (2015)

Background: Morbid obesity (BMI [body mass index], ≥40 kg/m2) is associated with a higher risk of complications, including infection and implant failure, following primary total hip arthroplasty. The purpose of this study was to compare the results of two-stage revision total hip arthroplasty for infection in a morbidly obese patient cohort (BMI, ≥40 kg/m2) and nonobese patients (BMI, <30 kg/m2). Methods: Using an institutional total joint registry, we reviewed the medical records of 653 patients treated with two-stage revision total hip arthroplasty for periprosthetic joint infection over a twenty-year period (1987 to 2007). Patients were stratified according to preoperative BMI. Thirty-three patients (fourteen male and nineteen female) with a BMI of ≥40 kg/m2 were identified. These patients were matched 1:2 with a cohort of sixty-six patients (twenty-eight male and thirty-eight female) of the same sex and similar age (91% within two years) who were not obese (BMI, <30 kg/m2). All patients had a minimum of five years of clinical follow-up (mean, 8.1 years in the morbidly obese group and 10.3 years in the nonobese group). Results: Compared with nonobese patients, morbidly obese patients had significantly greater rates of reinfection (18% compared with 2%, p < 0.005), revision (42% compared with 11%, p < 0.001) and reoperation for any reason (61% compared with 12%, p < 0.001). Prior to surgery, the mean Harris Hip Score had been 50.6 in the morbidly obese group and 48.8 in the nonobese group, and these scores improved significantly in both groups postoperatively (p < 0.01). Conclusions: Morbidly obese patients have markedly elevated risks of reinfection, reoperation, and component resection as well as poorer intermediate-term clinical outcome scores compared with nonobese patients following revision total hip arthroplasty for periprosthetic joint infection. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Design and Control of a Morphing Chevron for Takeoff and Cruise Noise Reduction (2005)

‡Commercial high-bypass ratio turbofan engines generate high levels of noise as the jet exhaust mixes with the ambient air. Serrated aerodynamic devices, known as chevrons, positioned along the trailing edges of a jet engine’s primary and secondary exhaust nozzle have been shown to reduce jet noise at take off as well as shock-cell noise at cruise. Their optimum shape is a finely tuned compromise between noise-benefit and thrust-loss. We report here the development of a powered variable geometry chevron (PVGC) capable of transitioning between take off and cruise shapes. Actuators composed of thermally active nickel-titanium (NiTinol) shape memory alloy drive the shape change. A full scale PVGC was tested under representative flow conditions in Boeing’s Nozzle Test Facility (NTF). In this test a simple proportional-integral control system provided continuous control of the VGC tip immersion between take off and cruise conditions. The collected data supports the aerodynamic, thermal, and mechanical design of the PVGC as well as the control system approach.
Low-Feedback Sampling Rate Digital Predistortion Using Deep Neural Network for Wideband Wireless Transmitters (2020)

In this paper, a low-feedback-sampling-rate digital predistortion (DPD) method is proposed for wideband wireless transmitters and radio-frequency power amplifiers (PAs). This DPD method inserts a non-ideal real band-pass filter into the feedback loop to limit the feedback bandwidth. Meanwhile, to recover the band-limited feedback signal, it introduces a signal-recovery module that is based on the deep neural network (DNN). A data-preprocessing technique is proposed to reduce the amount of input data for the DNN and thereby significantly reducing its structural complexity. Also, the use of DNN makes it feasible to implement off-line training. Both the simplicity of the proposed DNN and the availability of off-line training reduce the system complexity in DPD. Experimental validation was performed on a PA driven by wideband orthogonal-frequency-division-multiplexing (OFDM) signals. The results demonstrated the superiority of the proposed method in under-sampling applications. The proposed DPD method achieved the same linearization performance as the state-of-art DPD methods while requiring a sampling rate that was approximately 5% less. Meanwhile, the proposed DPD method has been validated to have stronger anti-noise and generalization capabilities.
Pregnancy Outcomes in Patients with Crohnʼs Disease Treated with Infliximab: Results from the TREATTM Registry (2013)

Purpose: The knowledge of pregnancy outcomes in patients with Crohn's disease (CD) receiving antitumor necrosis factor therapy remains limited. Methods: TREAT is an observational registry which evaluates clinical safety outcomes in CD patients treated with infliximab (IFX) and other standards of care in North America. Pregnancy outcomes between July, 1999 and February, 2012 are reported. Results: 6,273 patients were enrolled; 3440 received IFX. At enrollment, IFX-treated patients had a disease duration of 8.4 years, had more severe disease, were more often smokers, and were using more concomitant medication(s) when compared to patients on other CD treatments. A total of 348 pregnancies have been reported in TREAT. Of these, 273 were maternal pregnancies, and 105 occurred in mothers treated with IFX. IFX-treated mothers had higher disease activity during pregnancy: 17.3% had moderate-to-severe disease, 48.0% had mild-to-moderate disease, and 34.7% were in remission, compared to 3.4%, 37.5%, and 58% of the mothers on other CD treatments, respectively. Of the IFX-treated mothers, 33.7% were on AZA/6-MP, and 26.5% were on prednisone during pregnancy, compared to 36.4% and 11.4% of the mothers in the other-treatment-only group. Through an average of 6 years of patient follow-up, 81.6% (80/98) of pregnancies with known outcome in IFX-exposed mothers and 91.0% (81/89) in other-treatments-only exposed mothers resulted in live births (p=0.064). Spontaneous abortions were reported in 16.3% of IFX-treated and 9.0% of the other-treatment-only treated mothers (p=0.134). 92.5% of IFX-exposed and 87.7% of other-treatment-only live births resulted in healthy babies with no defect or other adverse event. One (1.3%) congenital malformation (an ectrodactyly in a familial context) was reported in the IFX-exposed infants, and 3 (3.7%) (a heart murmur associated with a suspicion of cystic fibrosis, a Down's syndrome, and a cortical vision delay) in the other-treatment-only infants. Five (4.8%) IFX-exposed infants were reported to have a prolonged hospital stay, compared to 12 (11.5%) in the other-treatment-only infants. Conclusion: Data from the TREAT registry show that the clinical condition of infants born to women with prenatal exposure to IFX is comparable to those exposed to other CD treatments. A trend for a lower rate of live birth was reported among IFX-exposed mothers, as compared to mothers not exposed to IFX. The confirmation of these results and the role of potential confounding factors, such as high disease activity before or during pregnancy, smoking, and concomitant medication use, will require further study. Disclosure - Lichtenstein GR, Feagan BG, Cohen RD, Salzberg BA, and Sandborn WJ-Grant/Research Support: Janssen Research and Development, LLC; Langholff W-Employee: Janssen Research and Development, LLC; Morgan J, Nissinen R, Reddy S, Taillard F-All employees Janssen Services, LLC. This research was supported by an industry grant from Janssen Research and Development, LLC.
Decomposable and responsive power models for multicore processors using performance counters (2010)

Power modeling based on performance monitoring counters (PMCs) attracted the interest of researchers since it became a quick approach to understand and analyse power behavior on real systems. As a result, several power-aware policies use power models to guide their decisions and to trigger low-level mechanisms such as voltage and frequency scaling. Hence, the presence of power models that are informative, accurate and capable of detecting power phases is critical to increase the power-aware research chances and to improve the success of power-saving techniques based on them. In addition, the design of current processors has varied considerably with the inclusion of multiple cores with some resources shared on a single die. As a result, PMC-based power models warrant further investigation on current energy-efficient multi-core processors.
Pyrrolopyridine or Pyrazolopyridine Derivatives (2015)

ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXTPyrrolopyridine or Pyrazolopyridine DerivativesBenjamin Blass*View Author Information Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, United States*Tel: 215-707-1085. E-mail: [email protected]Cite this: ACS Med. Chem. Lett. 2015, 6, 7, 726–728Publication Date (Web):June 5, 2015Publication History Received6 May 2015Published online5 June 2015Published inissue 9 July 2015https://pubs.acs.org/doi/10.1021/acsmedchemlett.5b00185https://doi.org/10.1021/acsmedchemlett.5b00185editorialACS PublicationsCopyright © 2015 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1537Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (320 KB) Get e-AlertscloseSUBJECTS:Alkyls,Central nervous system,Diseases and disorders,Nervous system diseases,Receptors Get e-Alerts
A new direct digital transmitter architecture for constant envelope modulation (2007)

A high speed direct digital synthesizer (DDS) based transmitter architecture is presented. The DDS driven by a sigma delta (SigmaDelta) locks by injection an LC-tank oscillator on an upper harmonic. Moreover, the injection locked oscillator (ILO) provides a band-pass filtering within its locking range which rejects out of band SigmaDelta quantization noise. The DDS is detailed in order to explain how to design an output signal frequency close to the clock frequency. Then the architecture is modulated thanks to constant envelope modulation. Finally, ILO output is compared to high constraint mask such as GSM/DCS in order to simulate architecture capability.
COVID-19 Contact-Tracing Mobile Apps: Evaluation and Assessment for Decision Makers (2020)

A number of groups, from governments to non-profits, have quickly acted to innovate the contact-tracing process: they are designing, building, and launching contact-tracing apps in response to the COVID-19 crisis. A diverse range of approaches exist, creating challenging choices for officials looking to implement contact-tracing technology in their community and raising concerns about these choices among citizens asked to participate in contact tracing. We are frequently asked how to evaluate and differentiate between the options for contact-tracing applications. Here, we share the questions we ask about app features and plans when reviewing the many contact-tracing apps appearing on the global stage.
Suberoylanilide hydroxamic acid (vorinostat) represses androgen receptor expression and acts synergistically with an androgen receptor antagonist to inhibit prostate cancer cell proliferation (2007)

Growth of prostate cancer cells is initially dependent on androgens, and androgen ablation therapy is used to control tumor growth. Unfortunately, resistance to androgen ablation therapy inevitably occurs, and there is an urgent need for better treatments for advanced prostate cancer. Histone deacetylase inhibitors, such as suberoylanilide hydroxamic acid (SAHA; vorinostat), are promising agents for the treatment of a range of malignancies, including prostate cancer. SAHA inhibited growth of the androgen-responsive LNCaP prostate cancer cell line at low micromolar concentrations and induced caspase-dependent apoptosis associated with chromatin condensation, DNA fragmentation, and mitochondrial membrane depolarization at higher concentrations (>/=5 mumol/L). Gene profiling and immunoblot analyses showed a decrease in androgen receptor (AR) mRNA and protein in LNCaP cells cultured with SAHA compared with control cells, with a corresponding decrease in levels of the AR-regulated gene, prostate-specific antigen. Culture of LNCaP cells in steroid-free medium markedly sensitized the cells to SAHA. Moreover, a combination of low, subeffective doses of SAHA and the AR antagonist bicalutamide resulted in a synergistic reduction in cell proliferation and increase in caspase-dependent cell death. Addition of exogenous androgen prevented the induction of cell death, indicating that suppression of androgen signaling was required for synergy. At the subeffective concentrations, these agents had no effect, alone or in combination, on proliferation or death of AR-negative PC-3 prostate cancer cells. Our findings indicate that SAHA is effective in targeting the AR signaling axis and that androgen deprivation sensitizes prostate cancer cells to SAHA. Consequently, combinatorial treatments that target different components of the AR pathway may afford a more effective strategy to control the growth of prostate cancer cells.
Total Shoulder Arthroplasty with an All-Polyethylene Pegged Bone-Ingrowth Glenoid Component (2012)

Total shoulder arthroplasty with a minimally cemented, all-polyethylene, pegged glenoid implant can yield stable and durable fixation at short to medium-term follow-up (mean, four years).
Syntheses and Antifungal Activity of dl-Griseofulvin and Its Congeners. III. (1997)

Several congeners (1b-g), with novel substituents on the benzene ring of griseofulvin, were prepared by the application of a synthetic method developed by us. Antifungal activity of these congeners decreased in order of dl-griseofulvin (1a) = 1d > 1b, c >> 1e-f (inactive). The relationship between the antifungal activity and the position or kind of substituents on the benzene ring of griseofulvin is discussed.
Supplementary Table 1 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity (2023)

&lt;p&gt;PDF file - 15KB, Primer sequences and PCR conditions for the indicated construct.&lt;/p&gt;
Proceedings of air toxic reduction and combustion modeling (1992)

This book contains proceedings of Air Toxic Reduction and Combustion Modelling. Topics include modeling of furnaces, burners, combustors, gaseous flames, spray combustion, coal and coal slurry combustion. Both fundamental and applied studies in the area of pollution control, including NO[sub x], and efficiency are of interest. Systems of special interest included furnaces and boilers, gas turbine combustion, internal combustion engines and other power generation systems. Fundamental and applied, as well as numerical and experimental studies were of interest, with emphasis on the evolution of toxic metals and the modeling of rotary-kiln and fluidized-bed incinerators.
Toward a widely tunable narrow linewidth RF source through heterogenous silicon photonic integration (2012)

By mixing two lasers together it, is possible to generate RF signals from near DC to hundreds of GHz. Through the use of a narrow-linewidth low-frequency oscillator, optical modulator, and injection locking, much higher frequency outputs can be produced that still retain the narrow linewidth of the low frequency oscillator. Here we focus on the design and implementation of an integrated device including photonic sources and modulators to realize the system described above. Specifically, we report on the creation and mixing of two tunable lasers on a silicon platform with a heterogeneously integrated gain medium realized in a III-V material system.
Determination of citric acid based on inhibition of the crystal growth of calcium fluoride (1991)

Inhibition of the growth of calcium fluoride crystals in the presence of citrate was followed using a kinetic-potentiometric technique and a calcium ion-selective electrode, and as a consequence, a method for the determination of citrate in the range 0.5-2.4 micrograms ml-1 has been developed. The method was successfully applied to the determination of citrate contained in pharmaceutical products and urine. Urine analysis requires prior separation of phosphate, sulphate and magnesium(II). Elimination of these interferences was studied and accomplished using precipitation processes. Magnesium and phosphate were jointly eliminated in basic media by the addition of ammonium ions. Phosphate and sulphate were eliminated with barium(II). Phosphate was also eliminated as a lithium salt.
3413 A Compact Electronic-Throttle-Control Actuator with Plastic-Cover Integrated Throttle-Position Sensor (2001)

A potentiometer-type throttle-position sensor, wiring, a connector and a cover for the throttle drive mechanism are integrated in order to reduce the size of an electronic-throttle-control actuator. The throttle-position sensor inside the integrated cover showed a large signal deviation when the environmental temperature changed. This output deviation was caused by the temperature expansion of the plastic material of the integrated cover. With the aim of decreasing the output deviation, we analyzed the temperature sensitivity of the throttle-position-sensor output in order to find optimum location for arc-shaped resistor track, and we increased the rigidity of the plastic gear-cover in order to decrease the effect of the temperature expansion.
Endoscopic system for in situ ultrasonic inspection of aero-engines using optically excited ultrasonic transducers (2013)

CHeap Optical Transducers (CHOTs) are a non-contact, wireless, couplant-free alternative to the traditional piezoelectric transducers and can be used for ultrasonic inspection. Because they are cheap and very small, they can be used in large numbers and in different ways to normal ultrasonic probes. For example, they could be mounted permanently on the component for easy repeatable measurements or considered as disposables: use once and throw away. CHOTs are structures attached to the surface of the test component that are optically excited using a simple laser set-up to either generate or detect ultrasound. The use of CHOTs enables testing of components inaccessible by other techniques and potentially enabling on-site and in-service ultrasonic testing currently unavailable to the industry. An example case study of CHOTs for in situ inspection of aero-engines, without dismantling them will be presented. An endoscopic system for CHOTs excitation has been developed which uses optical fibres for generating and detecting the ultrasonic signal. The design and construction of the portable system will be presented as well as the various methods for fabricating, attaching and "reading" the CHOTs.
Amelioration of cardiodepressive effects of gadopentetate dimeglumine with addition of ionic calcium. (1992)

Doses of gadopentetate dimeglumine of 0.1-0.5 mmol/kg cause cardiodepressive effects when injected as a rapid central bolus into the left jugular vein. This study evaluated the hemodynamic effects of this magnetic resonance imaging contrast medium with and without calcium supplementation in a rat model. Also, the potential of gadopentetate dimeglumine to bind ionized serum calcium was investigated in vitro. Addition of calcium ions resulted in dose-dependent attenuation of the hemodynamic depression induced by gadopentetate dimeglumine alone. The cardiodepressive response was negated for a 0.1-mmol/kg dose of the contrast agent by addition of 6 mumol/kg of calcium, for a 0.3-mmol/kg dose by addition of 12 mumol/kg of calcium, and for a 0.5-mmol/kg dose by addition of 18 mumol/kg of calcium. Concentrations of 2 and 4 mmol/L of gadopentetate dimeglumine were found to bind 5.1% and 10.1% of the ionized calcium in rat serum under in vitro conditions, respectively.
15‐Amido Erythromycins: Synthesis and in vitro Activity of a New Class of Macrolide Antibiotics. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Identification of a Calcium Binding Site in Staphylococcus hyicus Lipase:  Generation of Calcium-Independent Variants (1998)

In this study we have identified the presence of a high-affinity binding site for calcium in the lipase from Staphylococcus hyicus. By means of isothermal titration calorimetry we showed that the enzyme binds one calcium per molecule of enzyme with a dissociation constant of 55 microM. The residual activity of the apoenzyme compared to the activity in the presence of calcium ions varies from 65% at 10 degreesC to nearly zero at 40 degreesC. On the basis of primary sequence alignment with other staphylococcal lipases and the lipases from Bacillus thermocatenulatus and from Pseudomonas glumae in combination with site-directed mutagenesis, aspartates 354 and 357 could be identified as calcium ligands. Kinetic measurements with the D357E variant showed that replacement of Asp357 by a glutamate decreased the affinity for calcium ions 30-fold. Introduction of a lysine, an asparagine, or an alanine at position 357 and of a lysine or an asparagine at position 354 resulted in calcium-independent variants. Isothermal titration calorimetry confirmed the loss of calcium binding. Although the D357K, D357N, and D357A variants did not bind calcium, at room temperature they were nearly as active as wild-type lipase in the presence of calcium, but at elevated temperatures these calcium-independent lipases showed a reduced activity. Over the whole temperature range the activities of the D354K and D354N variants are significantly lower than wild-type enzyme in the presence of calcium and are comparable to the activity of the wild-type apoenzyme. Our results show that binding of calcium is important for the structural stabilization of staphylococcal lipases (and possibly other lipases) and that it is possible to engineer calcium-independent variants on the basis of limited structural homology with another lipase.
Bismuth-loaded plastic scintillator portal monitors (2018)

Plastic scintillators incorporating 8 weight percent elemental Bismuth offer enhanced sensitivity and distinct photopeak spectra in the &lt;1000 keV range typically used in radiation portal monitors. The Bismuth-loaded plastic is based on polyvinyl toluene with standard singlet fluors. It produces ~6,000 photons/MeV with a maximum emission at 430 nm and a ~10 ns decay. Energy resolution of 49% at 59.5 keV and 16% at 662 keV are obtained for a 14 in<sup>3</sup> Bismuth plastic scintillator plate. Count rates compared to standard plastic scintillator of the same size reveal a sensitivity improvement of &gt;5x in the &lt;200 keV range. Future spectroscopic radiation portal monitors based on the Bismuth plastic scintillator could provide moderate resolution spectroscopy for radioisotope identification. In addition, the Bismuth plastic offers outstanding environmental stability to weathering effects, in contrast with standard plastic scintillator formulations.