gebhart/patrepeval huggingface dataset:
LMM - A Common Component for Software License Management on Cloud (2013)

On a cloud environment, the platform that runs a program is not fixed, and there is a possibility that a program runs on several servers in a cloud environment. Transferability of the license information by a valid user should be allowed, even though general requirements for license management have to be satisfied. In this paper, we consider software license management models for cloud environments, and discuss security functions for building secure license management schemes. We show four license management models and analyze the security requirements for the models. Then, we design a common component referred to as the license management module (LMM), and explain the security functions required for the LMM. Furthermore, we discuss how to realize the security functions and evaluate their performance using a prototype implementation.
Small Molecule Insulin Receptor Activators Potentiate Insulin Action in Insulin-Resistant Cells (2001)

In type 2 diabetes, impaired insulin signaling leads to hyperglycemia and other metabolic abnormalities. To study a new class of antidiabetic agents, we compared two small, nonpeptide molecules that activate insulin receptor (IR) beta-subunit tyrosine kinase activity: Merck L7, a direct IR agonist, and Telik's TLK16998, an IR sensitizer. In rat hepatoma cells (HTCs) that overexpress the IR (HTC-IR), IR autophosphorylation was directly activated by L7 in the absence of insulin. TLK16998 did not directly activate IR autophosphorylation, but it enhanced IR autophosphorylation in the presence of insulin. Tyrosine phosphorylation of an endogenous 185-kDa IR substrate was also significantly enhanced by both Merck L7 alone and TLK16998 plus insulin. Adding TLK16998 to L7 produced synergistic effects, further indicating that these two compounds act on the IR through separate mechanisms. We next studied HTC-IR(Delta485-599) cells, which overexpress a mutant IR with a deletion in the alpha-subunit connecting domain that does not undergo autophosphorylation in response to insulin binding. L7 was able to directly activate autophosphorylation of the deletion mutant IR in these cells, whereas TLK16998 had no effect. Compounds were then tested in three other cell models of impaired IR function. Both TLK16998 and Merck L7 improved IR autophosphorylation in cells with diminished IR signaling due to either treatment with tumor necrosis factor-alpha or overexpression of membrane glycoprotein PC-1. However, in TPA (tetradecanoylphorbol acetate)-treated cells, TLK16998 but not Merck L7 was able to significantly reverse the impaired insulin-stimulated IR autophosphorylation. In summary, these two classes of IR activators selectively increased IR function in a variety of insulin-resistant cell lines.
Nonlinear oscillations of gas bubbles in liquids: An interpretation of some experimental results (1983)

Measurements are presented in this paper of the pulsation amplitude of an individual air bubble that is levitated in a glycerine–water mixture by a stationary acoustic wave operating at a frequency of 22.2 kHz. Observations of the bubble pulsation for a wide range of bubble sizes demonstrate the existence of the n=2 harmonic resonance (ω≊ω0/2). The available theoretical information on linear and nonlinear bubble oscillations is adapted to apply to the specific experimental conditions. Comparisons made with the theory show excellent agreement between measurements and predictions.
Insights into Structural Evolution of Lithium Peroxides with Reduced Charge Overpotential in Li−O2 System (2019)

Abstract Reducing charge–discharge overpotential is of great significance to enhance the efficiency and cyclability of Li−O 2 batteries. Here a dramatically reduced charge overpotential (0.4 V) via a rational design of cathode architecture, which features highly uniform Pt and Pt 3 Co nanocrystals embedding within nitrogen‐doped cobalt@graphene heterostructures is successfully achieved. Because of the improvement in the catalytic efficiency for optimizing the electrical and dynamic properties, the cathode design enables promising electrochemical performance. More importantly, the results reveal different overpotentials prompted by different structural evolution of bulk Li 2 O 2 , which largely depends on the Pt modification approach (surface‐coating and bulk‐doping). This dependence is found to be attributed to the influence of Pt nanocomponents and their dispersion on the formation and decomposition mechanism of Li 2 O 2 . Density functional theory calculations provide mechanistic insights into the promotional effect of Pt and Pt 3 Co on the reduction of the charge overpotential. Finally, an inner relationship between overpotential and electrochemical kinetics is proposed.
Introduction (2022)

No AccessInjection Mold Design EngineeringOct 2022IntroductionDavid O. KazmerDavid O. KazmerSearch for more papers by this authorhttps://doi.org/10.3139/9781569908921.001SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2022Pages: 1-21Print ISBN: 978-1-56990-891-4eISBN: 978-1-56990-892-1 Copyright & Permissions© 2022 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
A proven methodology for designing one-million-gate ASICs (2002)

This paper describes the methodology used to design a family of ASIC chips in the 400 K to one-million-gate range in a 0.5 micron technology. Working first-pass hardware was produced at an average clock speed of 100 MHz with over 99% testability. The methodology utilized a variety of third-party CAD tools from Synopsys and Cadence in combination with proprietary IBM tools.
Recent Progress in Electro-Optical Three-Dimensional Correlators (2001)

Three-dimensional (3D) spatial correlations can be done fast and in parallel due to the use of optics.We survey recent developments in 3D electro-optical correlators. Several architectures of the correlator are presented including the 3D joint transform correlator and the spatial filtering scheme. Examples from the field of pattern recognition are demonstrated. As a by-product of the 3D correlator, we present a method of hologram recording without wave interference.
H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice (2008)

Fatal human respiratory disease associated with the 1918 pandemic influenza virus and potentially pandemic H5N1 viruses is characterized by severe lung pathology, including pulmonary edema and extensive inflammatory infiltrate. Here, we quantified the cellular immune response to infection in the mouse lung by flow cytometry and demonstrate that mice infected with highly pathogenic (HP) H1N1 and H5N1 influenza viruses exhibit significantly high numbers of macrophages and neutrophils in the lungs compared to mice infected with low pathogenic (LP) viruses. Mice infected with the 1918 pandemic virus and a recent H5N1 human isolate show considerable similarities in overall lung cellularity, lung immune cell sub-population composition, and cellular immune temporal dynamics. Interestingly, while these similarities were observed, the HP H5N1 virus consistently elicited significantly higher levels of pro-inflammatory cytokines in whole lungs and primary human macrophages, revealing a potentially critical difference in the pathogenesis of H5N1 infections. Primary mouse and human macrophages and dendritic cells were also susceptible to 1918 and H5N1 influenza virus infection in vitro. These results together indicate that infection with HP influenza viruses such as H5N1 and the 1918 pandemic virus leads to a rapid cell recruitment of macrophages and neutrophils into the lungs, suggesting that these cells play a role in acute lung inflammation associated with HP influenza virus infection.
Cooperative effects in drug-DNA interactions (1987)

There have been several recent reviews on the interactions of drugs with DNA and the potential biological importance of these interactions [l–7].The structure of DNA has also been extensively discussed in a recent Cold Spring Harbor Symposium [8] and an excellent book has recently been published which summarizes our current knowledge of DNA structure [8a]. An area of growing interest and research investigation is the importance of cooperative binding of drug molecules to DNA and the influence of the cooperative effects on the biological activity of the drug molecules. The recent expansion in our knowledge of DNA and chromatin structure [8, 8a] as well as the development of theoretical models for treating cooperative and allosteric effects in drug-DNA models [9, 10] has been essential in initial efforts to develop an understanding of cooperativity in drug interactions. In this review the current state of our understanding of cooperative effects in drug-DNA interactions, the importance of drug and DNA structure to the cooperativity, and possible biological implications of the cooperative interactions will be presented.
Characterization of Xanthan—Protein Complexes Obtained with Various Fermentation Conditions (1993)

Fluid formulations used in the petroleum industry often contain synthetic polymers or biopolymers as thickening products. Biopolymers such as xanthan have different viscosifying properties, depending mainly on their chemical structure, acetate and pyruvate content and also on the purity of the samples, which can contain proteins. The main aim of this study was to investigate the effects of the origin and amount of proteins on the aggregation of xanthan chains in solution by means of rheological measurements. Modifications of fermentation conditions led to variations of intrinsic viscosity, Huggins constant and pyruvate content of the xanthan produced. The direct addition of protein-rich ingredients such as corn steep liquor or yeast extract to xanthan solutions also affected the rheological behavior of both diluted purified solutions and concentrated broth solutions. Aggregation effects on macromolecules chains and thixotropy phenomena have been observed. These effects are greatly dependent on salt content, pH, and nature of proteins, whether these proteins were added to xanthan solution or came from the fermentation medium.
1132: Salvage Cryosurgical Ablation of the Prostate (TCAP) for Patients Failing Radiation: Efficacy and Tolerability (2006)

You have accessJournal of UrologyDiscussed Poster, Tuesday, May 23, 2006, 9:00 am - 12:00 pm1 Apr 20061132: Salvage Cryosurgical Ablation of the Prostate (TCAP) for Patients Failing Radiation: Efficacy and Tolerability Aaron E. Katz, Kristofer Prepelica, James M. McKiernan, Carl A. Olsson, and Mitchell C. Benson Aaron E. KatzAaron E. Katz More articles by this author , Kristofer PrepelicaKristofer Prepelica More articles by this author , James M. McKiernanJames M. McKiernan More articles by this author , Carl A. OlssonCarl A. Olsson More articles by this author , and Mitchell C. BensonMitchell C. Benson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33357-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1132: Salvage Cryosurgical Ablation of the Prostate (TCAP) for Patients Failing Radiation: Efficacy and Tolerability." The Journal of Urology, 175(4S), p. 364 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 364 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Aaron E. Katz More articles by this author Kristofer Prepelica More articles by this author James M. McKiernan More articles by this author Carl A. Olsson More articles by this author Mitchell C. Benson More articles by this author Expand All Advertisement PDF DownloadLoading ...
Transforming face-to-face identity proofing into anonymous digital\n identity using the Bitcoin blockchain (2017)

The most fundamental purpose of blockchain technology is to enable\npersistent, consistent, distributed storage of information. Increasingly common\nare authentication systems that leverage this property to allow users to carry\ntheir personal data on a device while a hash of this data is signed by a\ntrusted authority and then put on a blockchain to be compared against. For\ninstance, in 2015, MIT introduced a schema for the publication of their\nacademic certificates based on this principle. In this work, we propose a way\nfor users to obtain assured identities based on face-to-face proofing that can\nthen be validated against a record on a blockchain. Moreover, in order to\nprovide anonymity, instead of storing a hash, we make use of a scheme of Brands\nto store a commitment against which one can perform zero-knowledge proofs of\nidentity. We also enforce the confidentiality of the underlying data by letting\nusers control a secret of their own. We show how our schema can be implemented\non Bitcoin's blockchain and how to save bandwidth by grouping commitments using\nMerkle trees to minimize the number of Bitcoin transactions that need to be\nsent. Finally, we describe a system in which users can gain access to services\nthanks to the identity records of our proposal.\n
Helicobacter pylori Infection Promotes Methylation and Silencing of Trefoil Factor 2, Leading to Gastric Tumor Development in Mice and Humans (2010)

Background &amp; Aims Trefoil factors (TFFs) regulate mucosal repair and suppress tumor formation in the stomach. Tff1 deficiency results in gastric cancer, whereas Tff2 deficiency increases gastric inflammation. TFF2 expression is frequently lost in gastric neoplasms, but the nature of the silencing mechanism and associated impact on tumorigenesis have not been determined. Methods We investigated the epigenetic silencing of TFF2 in gastric biopsy specimens from individuals with Helicobacter pylori-positive gastritis, intestinal metaplasia, gastric cancer, and disease-free controls. TFF2 function and methylation were manipulated in gastric cancer cell lines. The effects of Tff2 deficiency on tumor growth were investigated in the gp130 F/F mouse model of gastric cancer. Results In human tissue samples, DNA methylation at the TFF2 promoter began at the time of H pylori infection and increased throughout gastric tumor progression. TFF2 methylation levels were inversely correlated with TFF2 messenger RNA levels and could be used to discriminate between disease-free controls, H pylori-infected, and tumor tissues. Genome demethylation restored TFF2 expression in gastric cancer cell lines, so TFF2 silencing requires methylation. In Tff2-deficient gp130 F/F/Tff2 -/- mice, proliferation of mucosal cells and release of T helper cell type-1 (Th-1) 1 cytokines increased, whereas expression of gastric tumor suppressor genes and Th-2 cytokines were reduced, compared with gp130 F/Fcontrols.
Drag Free and Attitude Control System Design for the LISA Science Mode (2007)

The Laser Interferometer Space Antenna (LISA) Mission will enable scientists to detect and characterize gravitational waves emitted by different sources and events in our universe. LISA consists of three spacecraft flying in a triangular constellation with an arm-length of 5 mio. km in a heliocentric orbit approximately 20 degrees behind or in front of the Earth. One core technology required in order to achieve the mission requirements is the establishment of excellent free-fall conditions for the two proof-masses on board of each of the three spacecraft. The proof-masses must be isolated from external disturbances such that the residual acceleration remains below 3×10 m/s/√Hz between 0.1 and 1 mHz. In addition to the free-fall conditions, the relative jitter between the proof-masses and the spacecraft must be controlled to 2 nm/√Hz between 1 mHz and 1 Hz in order to ensure that the optical metrology achieves its required performance. Last but not least, the instrument pointing must be controlled to 8 nrad/√Hz between 1 mHz and 1 Hz in order to ensure that the inter-spacecraft laser-link achieves its required metrology performance. In this paper, a methodology is developed such that requirements for all control loops can be derived from system level requirements. Based on the requirements for each individual control loop, the feasibility of a controller design can be ensured even before an actual design has been performed. A reference design is then tested on a fully coupled linear model and verified in the framework of a non-linear time-domain simulation..
Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold(I) coordination complexes (1986)

A series of gold(I) coordination complexes including analogues of the antiarthritic agent auranofin 1 were evaluated for in vitro cytotoxic potency against both B16 melanoma cells and P388 leukemia cells and in vivo antitumor activity against P388 leukemia in mice. A number of the complexes showed potent cytotoxic activity in vitro and antitumor activity in vivo, with the phosphine-coordinated gold(I) thiosugar complexes demonstrating the greatest in vitro and in vivo activity. The data compiled for 63 complexes of the general structural formula LAuX provide the basis for the following observations: potent in vitro cytotoxic activity is observed for substituted (phosphine) gold complexes, lack of potency in vitro correlates well with lack of antitumor activity, potent cytotoxicity in vitro is not necessarily predictive of activity in vivo, in vivo antitumor activity is generally optimized by ligation of Au(I) with a substituted phosphine and a thiosugar.
A High Capacity and Long Reach DWDM-PON Using Triple-Contact F-P LDs (2010)

We propose a color-free DWDM-PON at 50 GHz channel spacing by using the triple contact F-P LD. The transmission length of 30 km and 90 km are demonstrated with and without FEC at 1.25 Gb/s-per-channel.
Formation of Patterned Microstructures of Conducting Polymers by Soft Lithography, and Applications in Microelectronic Device Fabrication (1999)

Micromolding in capillaries (MIMIC)has been used to form patterned relief structures with lateral dimensions as small as ∼350 nm. The microstructure in the figure consists of polyaniline (on an insulating Si/SiO2 base) that has been converted into the emeraldine salt to yield a conductive microstructure that could subsequently be used as a patterned electrode in fabricating all-plastic field effect transistors.
The assessment of enriched apoplastic extracts using proteomic approaches (2003)

In plant tissues the extracellular environment or apoplast, incorporating the cell wall, is a highly dynamic compartment with a role in many important plant processes including defence, development, signalling and assimilate partitioning. Soluble apoplast proteins from Arabidopsis thaliana, Triticum aestivum and Oryza sativa were separated by two-dimensional electrophoresis. The molecular weights and isoelectric points for the dominant proteins were established prior to excision, sequencing and identification by matrix-assisted laser-desorption ionisation time of flight mass spectrometry (MALDI - TOF MS). From the selected spots, 23 proteins from O. sativa and 25 proteins from A. thaliana were sequenced, of which nine identifications were made in O. sativa (39%) and 14 in A. thaliana (56%). This analysis revealed that: (i) patterns of proteins revealed by two-dimensional electrophoresis were different for each species indicating that speciation could occur at the level of the apoplast, (ii) of the proteins characterised many belonged to diverse families reflecting the multiple functions of the apoplast and (iii), a large number of the apoplast proteins could not be identified indicating that the majority of extracellular proteins are yet to be assigned. The principal proteins identified in the aqueous matrix of the apoplast were involved in defence, i.e. germin-like proteins or glucanases, and cell expansion, i.e. β-D-glucan glucohydrolases. This study has demonstrated that proteomic analysis can be used to resolve the apoplastic protein complement and to identify adaptive changes induced by environmental effectors.
Elastic Block Ciphers: The Feistel Cipher Case (2004)

We discuss the elastic versions of block ciphers whose round function processes subsets of bits from the data block differently, such as occurs in a Feistel network and in MISTY1. We focus on how specific bits are selected to be swapped after each round when forming the elastic version, using an elastic version of MISTY1 and differential cryptanalysis to illustrate why this swap step must be carefully designed. We also discuss the benefit of adding initial and final key dependent permutations in all elastic block ciphers. The implementation of the elastic version of MISTY1 is analyzed from a performance perspective.
A new synthesis ofD-glycosiduronates from unprotectedD-uronic acids (1995)

O-Glycosidation of totally O-unprotected D-galacturonic acid 1 in THF provides α-pyranosides 4a when promoted with BF3·OEt2 whereas β-furanosides 6β were obtained in the presence of FeCl3; when the same reaction is performed with D-glucuronic acid 2 or ‘D-glucurone’3, alkyl-D-glucofuranosidurono-6,3-lactones 7 are synthesized in excellent yields and high β-selectivity.
The antiproliferative action of deoxyspergualin is different from that induced by amine oxidase. (1988)

The amine oxidase activities contained in calf serum and human serum were detected at levels of 90.8 and less than 0.1 nmol O2/minute/ml serum, respectively, by measuring oxygen consumption coupled with spermidine oxidation. Deoxyspergualin (NKT-01) and spergualin (SGL) containing spermidine in their structure were also oxidized in calf serum at the rate of 3.6 and 11.6 nmol O2/minute/ml serum, respectively. To investigate whether amine oxidase is essential for NKT-01 and SGL to exhibit their antiproliferative activities or not, the in vitro activities of NKT-01, SGL and polyamines against L1210 cells were examined in the presence of calf or human serum. Polyamines exhibited antiproliferative activity only in the presence of calf serum, while NKT-01 and SGL inhibited cell growth in the presence of both calf and human serum. In the presence of calf serum the activity of NKT-01 was inhibited by aminoguanidine, an amine oxidase inhibitor. Aminoguanidine did not inhibit the activity of NKT-01 in the presence of human serum. The activity of NKT-01 was shown at much lower concentrations in the presence of human serum than that in the presence of calf serum, and was strongly dependent on incubation time. The in vivo activities of NKT-01, SGL and SGL derivatives correlated with their in vitro activities in the presence of human serum. These results suggest that the in vivo antitumor activities of NKT-01, SGL and SGL derivatives may be attributed to a mechanism different from those of amine oxidase-oxidized product and represent a novel growth inhibitory action.
New Six- to Eight-Membered-Ring Formation Based on the lntramolecular Endo-Mode Ring Closure of Allenyl (Substituted Phenyl)alkyl Ketones (1994)

Abstract Several allenyl ketones possessing an aryl group were submitted to a new intramolecular endo-mode cyclization with BF3·OEt2 or TiCl4 in CH2Cl2 to afford the corresponding 6-, 7-, and 8-membered carbocyclic products.