gebhart/patrepeval huggingface dataset:
2-Norbornyl anion. Selectivity in exo-endo proton capture (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2-Norbornyl anion. Selectivity in exo-endo proton captureJ. K. Stille, W. A. Feld, and M. E. FreeburgerCite this: J. Am. Chem. Soc. 1972, 94, 24, 8485–8489Publication Date (Print):November 1, 1972Publication History Published online1 May 2002Published inissue 1 November 1972https://pubs.acs.org/doi/10.1021/ja00779a030https://doi.org/10.1021/ja00779a030research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nutritionally related strategies for evaluation of vegetable oil and seedcake from seeds of a Cynara cardunculus Greek cultivar. From by-products to the functional food chain (2021)

Cynara cardunculus is a native plant in the Mediterranean basin, known for its therapeutic properties of its leaves, and its applications on bioenergy sector [1]. The seeds of a Greek artichoke cultivar have been recently studied [1], expressing promising phytochemical and nutrient profile with interesting bioactivities.
Signaling through 3′,5′-Cyclic Adenosine Monophosphate and Phosphoinositide-3 Kinase Induces Sodium/Iodide Symporter Expression in Breast Cancer (2004)

The sodium/iodide symporter (NIS) is a membrane transport glycoprotein normally expressed in the thyroid gland and lactating mammary gland. NIS is a target for radioiodide imaging and therapeutic ablation of thyroid carcinomas and has the potential for similar use in breast cancer treatment. To facilitate NIS-mediated radionuclide therapy, it is necessary to identify signaling pathways that lead to increased NIS expression and function in breast cancer. We examined NIS expression in mammary tumors of 14 genetically engineered mouse models to identify genetic manipulations associated with NIS induction. The cAMP and phosphoinositide-3 kinase (PI3K) signaling pathways are associated with NIS up-regulation. We showed that activation of PI3K alone is sufficient to increase NIS expression and radioiodide uptake in MCF-7 human breast cancer cells, whereas cAMP stimulation increases NIS promoter activity and NIS mRNA levels but is not sufficient to increase radioiodide uptake. This study is the first to demonstrate that NIS expression is induced by cAMP and/or PI3K in breast cancer both in vivo and in vitro.
ChemInform Abstract: Dysidotronic Acid, a New and Selective Human Phospholipase A2 Inhibitor from the Sponge Dysidea sp. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Conventional histological and cytological staining with simultaneous immunohistochemistry enabled by invisible chromogens (2021)

Conventional histological stains, such as hematoxylin plus eosin (H&E), and immunohistochemistry (IHC) are mainstays of histology that provide complementary diagnostic information. H&E and IHC currently require separate slides, because the stains would otherwise obscure one another. This consumes small specimen, limiting the total amount of testing. Additionally, performing H&E and IHC on different slides does not permit comparison of staining at the single cell level, since the same cells are not present on each slide, and alignment of tissue features can be problematic due to changes in tissue landscape with sectioning. We have solved these problems by performing conventional staining and IHC on the same slide using invisible IHC chromogens, such that the chromogens are not visible when viewing the conventional stain and the conventional stain is excluded from images of the IHC. Covalently deposited chromogens provided a convenient route to invisible chromogen design and are stable to reagents used in conventional staining. A dual-camera brightfield microscope system was developed that permits simultaneous viewing of both visible conventional stains and invisible IHC chromogens. Simultaneous staining was demonstrated on several formalin-fixed paraffin-embedded tissue specimens using single and duplex IHC, with chromogens that absorb ultraviolet and near infrared light, followed by H&E staining. The concept was extended to other conventional stains, including mucicarmine special stain and Papanicoulou stain, and further extended to cytology specimens. In addition to interactive video review, images were recorded using multispectral imaging and image processing to provide flexible production of color composite images and enable quantitative analysis.
On the reliability of gamma distributed dsds for modelling kinetic energy of rainfall* (2020)

Abstract To retrieve the gamma drop size distribution (DSD) parameters from observed drop spectra, the most common approach is the method of moments (MM). However, the goodness of this method is still disputed. To assess its reliability, the aims of this paper are: (i) estimation of empirical values of rainfall rate ( I ) and kinetic energy (KE) from DSD measurements collected by a laser‐optical disdrometer; (ii) estimation of gamma DSD parameters by MM and another widespread method, i.e. maximum likelihood (ML); (iii) evaluation of theoretical values of rainfall rate and KE and comparison between these values and measured ones. The novelty of this work is the assessment of both MM and ML using the rainfall intensity measured by the disdrometer as a benchmark, rather than the KE or a statistical test as done in common practice. The assessment of the goodness of the estimates was performed on variables most investigated in soil erosion studies (i.e. I and KE). Results show that smaller error values are associated with ML and that MM does not provide reliable estimations of I. On the other hand, both methods substantially underestimate KE with increasing rainfall intensity.
Myeloid cytokines distinctly and reversibly control LAIR-1 (CD305) expression on monocytes-mΦs/monocyte-DCs. (2016)

Abstract Cross-linking of the inhibitory immunoreceptor LAIR-1 (CD305) on the cell surface phosphorylates LAIR-1 inhibitory motifs (ITIM) and restricts the growth of monocyte-derived dendritic cells (mono-DCs). Despite the suggestion that LAIR-1’s ability to prevent unwarranted immunity is compromised in autoimmunity, much remains to be learned about the control of LAIR-1 expression. Here, we compared the ability of various myeloid cytokines to control LAIR-1 expression on the surface of monocytes/macrophages (mϕs) and mono-DCs. Treatment of freshly isolated blood monocytes from healthy donors with mono-DC growth factors (GM-CSF+IL-4/GM-CSF+IL-13) led to reduced levels of LAIR-1 at the critical monocyte-to-mono-DC juncture. In contrast, M-CSF (a steady state/M2 cytokine) sustained LAIR-1+CD14+CD33m/M+CD16+ mono-mϕs. M-CSF effects on LAIR-1 occurred under serum-supplemented and serum-free conditions. Addition of M-CSF to mono-DCs previously cultured in GM-CSF+IL-4 promptly reversed the down-regulatory effects of GM-CSF+IL-4 producing increases in LAIR-1+CD14+ cells. Conversely, addition of GM-CSF+IL-4 to M-CSF exposed cultures lowered levels of LAIR-1 and CD14. M-CSF treatment of SLE blood myeloid cells (featuring activated monocytes/mono-DCs lacking LAIR-1, CD14) produced high levels of LAIR-1 and CD14 vs GM-CSF/IL-4. Thus: 1. The expression of LAIR-1 on monocytes/mϕs and mono-DCs is distinctly and reversibly controlled by myeloid cytokines. 2. LAIR-1 expression on circulating myeloid cells in SLE may be regulated by M-CSF.
Ectopic insertion of the pectoralis minor: implication in the arthroscopic treatment of shoulder stiffness (2008)

Although ectopic insertion of the pectoralis minor has been previously described in the literature, the role of such anatomical variations in producing shoulder symptoms (i.e., pain and/or stiffness) remains controversial. We describe here a case of shoulder stiffness in which an ectopic insertion of the pectoralis minor over the supraspinatus tendon was found to be the main reason for severe contracture in external rotation and anterior thoracic pain. During arthroscopy, external rotation could not be restored despite anterior and inferior capsulotomy and release of the capsule of the rotator interval. Complete restoration of the passive external rotation was obtained only after complete release of the pectoralis minor from the supraspinatus. This observation underlines the importance of recognising such an anatomical variation when performing an arthroscopic arthrolysis in a stiff shoulder.
Substrate regulation and specificity of amylases fromAureobasidiumstrain NRRL Y-12,974 (1993)

Pullulan is an industrial biopolymer produced by the yeast-like fungus Aureobasidium, usually by direct fermentation of starch.Despite evidence that autogenous amylases produced during these fermentations are detrimental to the final molecular mass of the product, fundamental studies of these enzymes have not been reported.Total extraceUular amylases were studied from the promising production strain NRRL Y-12,974.Growth rates and yields were equivalent in cultures grown on glucose, maltose, soluble starch, or cornstarch.Total amylase levels were low and varied only three-fold, from 0.01 IU m1-1 in glucose-grown cultures to 0.03 IU m1-1 in soluble-starch-grown cultures.All cultures showed both a-amylase activity and activity against pullulan.Synthetic oligosaccharide substrates were apparently attacked by an a-glucosidase, produced in highest levels by maltose-grown cultures.
Optimal design of a tunable thomson-scattering based gamma-ray source (2007)

Thomson-scattering based systems offer a path to high-brightness high-energy (> 1 MeV) X-ray and gamma-ray sources due to their favorable scaling with electron energy. LLNL is currently engaged in an effort to optimize such a device, dubbed the "Thomson-Radiated Extreme X-ray" (T-REX) source, targeting up to 680 keV photon energy. Such a system requires precise design of the interaction between a high-intensity laser pulse and a high-brightness electron beam. Presented here are the optimal design parameters for such an interaction, including factors such as the collision angle, focal spot size, optimal bunch charge, and laser energy. These parameters were chosen based on extensive modelling using PARMELA and in-house, well-benchmarked scattering simulation codes.
Low temperature metal interdiffusion bonding for micro devices (2012)

We demonstrate solid liquid interdiffusion bonding by gallium and gold as bonding material and show the bonding at 40°C. Because of the low melting point of gallium of 29.8°C several difficulties for processing the gallium exists. We could successful develop deposition, structuring and bonding processes.
Clasificación funcional de la hipertensión pulmonar en niños: Informe del task force pediátrico del Pulmonary Vascular Research Institute (PVRI), Panamá 2011 (2012)

Los miembros del Task Force pediátrico del Pulmonary Vascular Research Institute (PVRI, su sigla en Inglés) fueron conscientes de la necesidad de desarrollar una clasificación funcional de la hipertensión pulmonar en niños. La clasificación que se propone sigue el mismo patrón y utiliza los mismos criterios de la clasificación de la hipertensión pulmonar específica para adultos de Dana Point. Fue necesario incluir modificaciones para los niños, teniendo en cuenta que la edad, el crecimiento físico y la madurez influyen en la expresión funcional de la enfermedad. Es necesario definir el estado clínico del niño, pues ello facilita revisar la evolución del mismo en una forma consistente y objetiva a medida que él/ella crecen. Particularmente en los niños más jóvenes, se trató de incluir indicadores objetivos como el crecimiento, la necesidad de alimentos suplementarios y los registros de asistencia al colegio y a la guardería. Esto ayuda a monitorear la evolución clínica y la respuesta al tratamiento a través de los años y facilita el desarrollo de algoritmos de tratamiento en estos pacientes. Se presenta un artículo de consenso sobre una clasificación aplicable a los niños con hipertensión pulmonar que se discutió en la reunión anual del PVRI que se llevó a cabo en Panamá en febrero de 2011. The members of the Pediatric Task Force of the Pulmonary Vascular Research Institute (PVRI) were aware of the need to develop a functional classification of pulmonary hypertension in children. The proposed classification follows the same pattern and uses the same criteria as the Dana Point pulmonary hypertension specific classification for adults. Modifications were necessary for children, since age, physical growth and maturation influences the way in which the functional effects of a disease are expressed. It is essential to encapsulate a child's clinical status, to make it possible to review progress with time as he/she grows up, as consistently and as objectively as possible. Particularly in younger children we sought to include objective indicators such as thriving, need for supplemental feeds and the record of school or nursery attendance. This helps monitor the clinical course of events and response to treatment over the years. It also facilitates the development of treatment algorithms for children. We present a consensus paper on a functional classification system for children with pulmonary hypertension, discussed at the Annual Meeting of the PVRI in Panama City, February 2011.
Synthesis of Molybdenum and Tungsten Alkylidene Complexes that Contain atert-Butylimido Ligand (2015)

A variety of molybdenum or tungsten complexes that contain a tert-butylimido ligand have been prepared. For example, the o-methoxybenzylidene complex W(N-t-Bu)(CH-o-MeOC6H4)(Cl)2(py) was prepared through addition of pyridinium chloride to W(N-t-Bu)2(CH2-o-MeOC6H4)2, while Mo(N-t-Bu)(CH-o-MeOC6H4)(ORF)2(t-BuNH2) complexes (ORF = OC6F5 or OC(CF3)3) were prepared through addition of two equivalents of RFOH to Mo(N-t-Bu)2(CH2-o-MeOC6H4)2. An X-ray crystallographic study of Mo(N-t-Bu)(CH-o-MeOC6H4)[OC(CF3)3]2(t-BuNH2) showed that the methoxy oxygen is bound to the metal and that two protons on the tert-butylamine ligand are only a short distance away from one of the CF3 groups on one of the perfluoro-tert-butoxide ligands (H···F = 2.456(17) and 2.467(17) Å). Other synthesized tungsten tert-butylimido complexes include W(N-t-Bu)(CH-o-MeOC6H4)(pyr)2(2,2′-bipyridine) (pyr = pyrrolide), W(N-t-Bu)(CH-o-MeOC6H4)(pyr)(OHMT) (OHMT = O-2,6-(mesityl)2C6H3), W(N-t-Bu)(CH-t-Bu)(OHMT)(Cl)(py) (py = pyridine), W(N-t-Bu)(CH-t-Bu)(OHMT)(Cl), W(N-t-Bu)(CH-t-Bu)(pyr)(ODFT)(py), W(N-t-Bu)(CH-t-Bu)(OHMT)2, and W(N-t-Bu)(CH-t-Bu)(ODFT)2 (ODFT = O-2,6-(C6F5)2C6H3). Interestingly, W(N-t-Bu)(CH-t-Bu)(OHMT)2 does not react with ethylene or 2,3-dicarbomethoxynorbornadiene. Removal of pyridine from W(N-t-Bu)(CH-t-Bu)(BiphenCF3)(pyridine) (BiphenCF3 = 3,3′-di-tert-butyl-5,5′-bistrifluoromethyl-6,6′-dimethyl-1,1′-biphenyl-2,2′-diolate) with B(C6F5)3 led to formation of a five-coordinate 14e neopentyl complex as a consequence of CH activation in one of the methyl groups in one tert-butyl group of the BiphenCF3 ligand, as was proven in an X-ray study. An attempted synthesis of W(N-t-Bu)(CH-t-Bu)(BiphenMe) (BiphenMe = 3,3′-di-tert-butyl-5,5′,6,6′-tetramethyl-1,1′-biphenyl-2,2′-diolate) led to formation of a 1:1 mixture of W(N-t-Bu)(CH-t-Bu)(BiphenMe) and a neopentyl complex analogous to the one characterized through an X-ray study. The metallacyclobutane complexes W(N-t-Bu)(C3H6)(pyrrolide)(ODFT) and W(N-t-Bu)(C3H6)(ODFT)2 were prepared in reactions involving W(N-t-Bu)(CH-t-Bu)(pyr)2(bipy), ZnCl2(dioxane), and one or two equivalents of DFTOH, respectively, under 1 atm of ethylene.
Auditory Mismatch Negativity: Detecting Spectral Contrasts in a Modulated Noise (2011)

The ability to detect sinusoidal spectral envelope from an unmodulated (flat) spectrum has shown a strong correlation with speech perception in quiet and noisy listening conditions in normal hearing, hearing-impaired, and cochlear implant users. In this study, the mismatch negativity (MMN) was collected from 10 normal-hearing adult listeners and used to determine if modulation detection thresholds derived electrophysiologically correlate with the psychophysically measured spectral modulation detection thresholds. MMNs were present for most participants with spectral contrasts of 10 and 20 dB, suggesting that the MMN may be a promising neurophysiologic measure of spectral envelope perception when nonbehavioral measures are desired.
Rheology of compatibilized immiscible blends with droplet-matrix and cocontinuous morphologies during coarsening (2014)

It is well known that addition of block copolymers to immiscible polymer blends may result in finer and more stable microstructures by reducing the driving force for coarsening, namely, the interfacial tension. This compatibilization is also reflected in the rheological behavior of the blends. We present an experimental study on the morphology and rheology of model blends composed of fluorescently labeled polystyrene and styrene-ran-acrylonitrile copolymer compatibilized with a polystyrene-b-polymethyl methacrylate diblock copolymer (BC). Three different weight ratios (wt/wt) are studied: 20/80, 35/65, and 50/50, with the following morphologies: Droplet/matrix, metastable cocontinuous, and abiding cocontinuous, respectively. It is found that regardless the type of initial morphology, the addition of BC reduces the characteristic size and increases the elastic modulus in the terminal regime, where the relaxation of the interface is probed. The relaxation spectra in the terminal zone are greatly affected by the presence of BC, which reflects the strong dependence of the viscoelastic behavior on the local microstructure (shape and area) of the interface. Furthermore, the addition of BC reduces the rate of coarsening, which is characterized by the time evolution of both the elastic modulus and the specific interfacial area. These effects are more pronounced when the molecular weight or concentration of the BC is higher. Finally, two regimes of coarsening in the symmetric (50/50) blends were identified and characterized by two different power laws.
The inositol pyrophosphate 5-InsP 7 drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85α (2020)

Sodium/potassium-transporting adenosine triphosphatase (Na<sup>+</sup>/K<sup>+</sup>-ATPase) is one of the most abundant cell membrane proteins and is essential for eukaryotes. Endogenous negative regulators have long been postulated to play an important role in regulating the activity and stability of Na<sup>+</sup>/K<sup>+</sup>-ATPase, but characterization of these regulators has been elusive. Mechanisms of regulating Na<sup>+</sup>/K<sup>+</sup>-ATPase homeostatic turnover are unknown. Here, we report that 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate (5-InsP<sub>7</sub>), generated by inositol hexakisphosphate kinase 1 (IP6K1), promotes physiological endocytosis and downstream degradation of Na<sup>+</sup>/K<sup>+</sup>-ATPase-α1. Deletion of IP6K1 elicits a twofold enrichment of Na<sup>+</sup>/K<sup>+</sup>-ATPase-α1 in plasma membranes of multiple tissues and cell types. Using a suite of synthetic chemical biology tools, we found that 5-InsP<sub>7</sub> binds the RhoGAP domain of phosphatidylinositol 3-kinase (PI3K) p85α to disinhibit its interaction with Na<sup>+</sup>/K<sup>+</sup>-ATPase-α1. This recruits adaptor protein 2 (AP2) and triggers the clathrin-mediated endocytosis of Na<sup>+</sup>/K<sup>+</sup>-ATPase-α1. Our study identifies 5-InsP<sub>7</sub> as an endogenous negative regulator of Na<sup>+</sup>/K<sup>+</sup>-ATPase-α1.
The Multi-angle Extended Three-dimensional Activities (META) stimulus set: A tool for studying event cognition (2022)

Accepted for publication in Behavior Research Methods.
Improved luminance and efficiency of ZnS-Mn and GaN:Eu TDEL devices using PZT thick dielectric films (2004)

In this paper, we report on the optimization of TDEL devices in both the phosphor material and the device structure. The TDEL device consists of a metal-insulator-semiconductor-insulator-metal (MISIM) stacked film structure built upon a transparent glass substrate. The high dielectric constant and break down field of PZT thick dielectric film along with the other thin film stacks has enabled a significantly higher charge (>3 /spl mu/C/cm/sup 2/) transport across the phosphor layer. Furthermore, the nano-porous PZT film has reduced the intensity of high field points in the device, resulting in a steeper luminance-voltage slope after device turn-on. We have also found that the phosphor electric field of the TDEL surpasses that of a thin film electroluminescent (TFEL) device, resulting in higher efficiencies under same biasing conditions.
Microwave tomography. Experimental imaging on two and three dimensional systems (2002)

We have constructed two dimensional and three dimensional microwave tomographic systems. The quantitative experimental image reconstruction has been achieved in the 2D case in both low and high dielectric contrast cases. To reconstruct 3D images we generalized the Born approximation into the vector case. The images of the 3D mathematical models and experimental phantoms have been achieved in case of low contrast of dielectrical properties.
63877 Railway Vehicle Derailment Simulation for Derailment Detection System in Early Signs(Railroad System Dynamics) (2010)

This paper proposes a derailment detection system in early signs of a railway vehicle. The proposed system detects abnormal vehicle signs before derailment using micro-electromechanical system acceleration sensors for automobiles. The new derailment detection algorithm was proposed in the former report. In this paper, a real-scale vehicle simulation is performed to apply the new derailment detection algorithm to an actual vehicle. At first, 1/10-scale vehicle simulation results are verified by using experimental results to indicate a reliability of the real-scale vehicle simulation. Finally, the real-scale vehicle results are performed in some derailment conditions.