gebhart/patrepeval huggingface dataset:
Stereochemical studies on protonated bridgehead amines. Proton NMR determination of cis and trans B-C ring-fused structures for salts of hexahydropyrrolo[2,1-a]isoquinolines and related C ring homologs. Capture of unstable ring-fused structures in the solid state [Erratum to document cited in CA110(17):153489F] (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemical studies on protonated bridgehead amines. Proton NMR determination of cis and trans B-C ring-fused structures for salts of hexahydropyrrolo[2,1-a]isoquinolines and related C ring homologs. Capture of unstable ring-fused structures in the solid state [Erratum to document cited in CA110(17):153489F]Bruce E. Maryanoff, David F. McComsey, Ruth R. Inners, Martin S. Mutter, Gary P. Wooden, Stephen L. Mayo, and R. A. OlofsonCite this: J. Am. Chem. Soc. 1989, 111, 20, 8062Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://pubs.acs.org/doi/10.1021/ja00202a086https://doi.org/10.1021/ja00202a086research-articleACS PublicationsRequest reuse permissionsArticle Views47Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Technical Note. Tracheobronchial Tree: Three-Dimensional Spiral CT with Bronchoscopic Perspective (1996)

The purpose of this report is to describe an original 3D technique that permits bronchoscopic perspective simulations of the tracheobronchial tree on an affordable workstation. Software based on surface shading was developed to permit navigation through the central airways using spiral CT data. Multiplanar reformations are displayed simultaneously with the virtual bronchoscopy simulations to give information about tissues surrounding the airways. Two clinical examples are reported to illustrate the value of this advanced computer technique.
A class of packet-switched extended generalized shuffle networks (1992)

Extended generalized shuffle (EGS) networks 1 have recently been proposed as a broad class of multistage interconnection networks (MINs) that include strictly non-blocking networks as well as networks with finite blocking probabilities. These networks can be viewed as extensions to generalized shuffle networks 2 (GSNs) that include the facility to fan-out and fan-in at the input and output stages, respectively, of the interconnection network. We present a new class of packets-witched EGS networks. At the heart of these networks is a unipath EGS network that allows a continuous tradeoff between a crossbar and a traditional MIN in terms of fan-out and fan-in versus number of stages. We show how switching networks with self-routing capability and arbitrarily low packet contention rates can be achieved by replicating the unipath network. We also compare the performance and cost of such networks with those of the GSN. Finally, we discuss the utility of these new packet-switched networks for photonic switching using smart pixels.
Trifluoromethanesulfonyl Azide: An Efficient Reagent for the Preparation of α‐Cyano‐α‐diazo Carbonyls and an α‐Sulfonyl‐α‐diazo Carbonyl. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Minimization of Ice Adhesion to Space Shuttle Component Surfaces (2012)

Abstract The goals of this two-phase experimental program were to optimize the effectiveness of an icephobic coating for use on several Space Shuttle surfaces. Coating application with a foam brush provided consistent, controlled and reproducible surface coverage. Ice samples were grown slowly and consistently at −10°C prior to cooling to a constant −112°C temperature for cryogenic double lap shear testing. Phase 1 tests were focused on finding an optimal coating mix of Rain-X and varying weight fractions of PTFE powders MP-55 and UF-8TA. The MP-55 coatings produced large reductions in ice adhesion to aluminum coupons while the UF-8TA coatings were similar to uncoated controls. The M4 mixture with 40% MP-55 and 60% Rain-X gave the best and most consistent coating with outstanding performance and durability through five cycles of ice growth and adhesion failure. Phase 2 tests verified the effectiveness and durability of this coating over Koropon, Kapton tape, Kapton film and fire-retardant-paint surfaces on the shuttle and quantified the changes in effectiveness resulting from the addition of an ultraviolet light absorber (UVA). Solvent loss from Rain-X during prolonged mixing of the coating caused a greater increase in ice adhesion than that by adding the UVA.
Dual System To Reinforce Biological Containment of Recombinant Bacteria Designed for Rhizoremediation (2001)

Active biological containment (ABC) systems have been designed to control at will the survival or death of a bacterial population. These systems are based on the use of a killing gene, e.g., a porin-inducing protein such as the one encoded by the Escherichia coli gef gene, and a regulatory circuit that controls expression of the killing gene in response to the presence or absence of environmental signals. An ABC system for recombinant microorganisms that degrade a model pollutant was designed on the basis of the Pseudomonas putida TOL plasmid meta-cleavage regulatory circuit. The system consists of a fusion of the Pm promoter to lacI, whose expression is controlled by XylS with 3-methylbenzoate, and a fusion of a synthetic P(lac) promoter to gef. In the presence of the model pollutant, bacterial cells survived and degraded the target compound, whereas in the absence of the aromatic carboxylic acid cell death was induced. The system had two main drawbacks: (i) the slow death of the bacterial cells in soil versus the fast killing rate in liquid cultures in laboratory assays, and (ii) the appearance of mutants, at a rate of about 10(-8) per cell and generation, that did not die after the pollutant had been exhausted. We reinforced the ABC system by including it in a Deltaasd P. putida background. A P. putida Deltaasd mutant is viable only in complex medium supplemented with diaminopimelic acid, methionine, lysine, and threonine. We constructed a P. putida Deltaasd strain, called MCR7, with a Pm::asd fusion in the host chromosome. This strain was viable in the presence of 3-methylbenzoate because synthesis of the essential metabolites was achieved through XylS-dependent induction. In the P. putida MCR7 strain, an ABC system (Pm::lacI, xylS, P(lac)::gef) was incorporated into the host chromosome to yield strain MCR8. The number of MCR8 mutants that escaped killing was below our detection limit (<10(-9) mutants per cell and generation). The MCR8 strain survived and colonized rhizosphere soil with 3-methylbenzoate at a level similar to that of the wild-type strain. However, it disappeared in less than 20 to 25 days in soils without the pollutant, whereas an asd(+), biologically contained counterpart such as P. putida CMC4 was still detectable in soils after 100 days.
Enhancement of cyclability using recombination reaction of Cu for Sn2Fe nanocomposite anode for lithium-ion batteries (2010)

A Sn2Fe/C nanocomposite containing Cu was evaluated as an anode material for rechargeable lithium-ion batteries. The electrochemical reaction mechanism of this nanocomposite was examined by ex-situ X-ray diffraction and high resolution transmission electron microscopy. The Sn2Fe/C nanocomposite containing Cu showed dramatically improved cycling performance. The enhanced cyclability of the Sn2Fe/C nanocomposite containing Cu was attributed to both amorphization of the Sn2Fe phase and a recombination reaction between Sn and Cu during the charging step.
Growth and Photovoltaic Properties of High-Quality GaAs Nanowires Prepared by the Two-Source CVD Method (2016)

Growing high-quality and low-cost GaAs nanowires (NWs) as well as fabricating high-performance NW solar cells by facile means is an important development towards the cost-effective next-generation photovoltaics. In this work, highly crystalline, dense, and long GaAs NWs are successfully synthesized using a two-source method on non-crystalline SiO2 substrates by a simple solid-source chemical vapor deposition method. The high V/III ratio and precursor concentration enabled by this two-source configuration can significantly benefit the NW growth and suppress the crystal defect formation as compared with the conventional one-source system. Since less NW crystal defects would contribute fewer electrons being trapped by the surface oxides, the p-type conductivity is then greatly enhanced as revealed by the electrical characterization of fabricated NW devices. Furthermore, the individual single NW and high-density NW parallel arrays achieved by contact printing can be effectively fabricated into Schottky barrier solar cells simply by employing asymmetric Ni-Al contacts, along with an open circuit voltage of ~0.3 V. All these results indicate the technological promise of these high-quality two-source grown GaAs NWs, especially for the realization of facile Schottky solar cells utilizing the asymmetric Ni-Al contact.
Synthesis and Secondary Structure of Alternate α,β‐Hybrid Peptides Containing Oxazolidin‐2‐one Moieties (2007)

Abstract The synthesis and conformational analysis of a novel class of foldamers containing ( S )‐β 3 ‐homophenylglycine [( S )‐β 3 ‐hPhg] and D ‐4‐carboxy‐oxazolidin‐2‐one ( D ‐Oxd) residues in alternate order is reported. The experimental conformational analysis performed in solution by IR, 1 H NMR, and CD spectroscopy unambiguously proved that these oligomers fold into ordered structures with increasing sequence length. Theoretical calculations employing ab initio MO theory suggest a helix with 11‐membered hydrogen‐bonded rings as the preferred secondary structure type. The few formal helix alternatives can be excluded in particular by steric effects of the oxazolidin‐2‐one rings. The novel structures enrich the field of peptidic foldamers and might be useful in the mimicry of native peptides. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2007)
Supplementary Data from Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment (2023)

&lt;p&gt;Supplementary Methods&lt;/p&gt;
Differential Expression of Interferon Genes in a Substrain of Namalwa Cells (1985)

A substrain of Namalwa cells producing a high ratio of beta-interferon (IFN-beta) versus alpha-interferon (IFN-alpha) was investigated by constructing a cDNA library after induction with Sendai virus. The library was screened by two synthetic oligonucleotides, one specific for IFN-alpha and one complementary to both IFN-alpha and IFN-beta. Rescreening the library with two full-length cDNAs encoding IFN-alpha and IFN-beta, respectively, revealed that the frequency of the IFN-alpha and IFN-beta clones reflected the activities of IFN-alpha and IFN-beta obtained by functional assays. On the cDNA level, the dominating species was identical with the type of IFN-alpha A or IFN-alpha 2; however, one new type of cDNA also was found that was similar to the previously described IFN-alpha C. Only one type of cDNA was found encoding IFN-beta, although several IFN-beta proteins have been detected in the analyzed cell line.
OLED devices for signage applications: a review of recent advances and remaining challenges (2004)

Reported efficiency records of >70 lm/W and the community's performance roadmaps indicate the potential of OLEDs (Organic Light Emitting Diodes) for use in general lighting applications. Within a shorter timeframe, OLED technology may be exploited for signage applications. Key differences of OLED signage devices to display and lighting devices are discussed. Recent results are presented on large area device design, polymer deposition technology, device and material performance, and encapsulation technology. Finally we discuss performance and cost targets for potential applications indicating the main challenges for future developments.
Solarzellen (2011)

Mit den Solarzellen knüpfen wir nochmals an die Photodioden an, wir beschränken uns auf die bisher wirtschaftlich relevanten Zellen mit pn-Übergang in Halbleitertechnologie. Wir betrachten einen beleuchteten pn-Übergang ohne äußere Spannung, aber mit einem Lastwiderstand. Damit wird der bisher noch nicht behandelte vierte Quadrant der Kennlinie einer pn- Halbleiterdiode relevant, siehe Bild 16-1 (die gesamte Kennlinie ist im Kapitel über die Photodiode gezeigt).
Do Mirror Glasses Have the Same Effect on Brain Activity as a Mirror Box? Evidence from a Functional Magnetic Resonance Imaging Study with Healthy Subjects (2015)

Since its original proposal, mirror therapy has been established as a successful neurorehabilitative intervention in several neurological disorders to recover motor function or to relieve pain. Mirror therapy seems to operate by reactivating the contralesional representation of the non-mirrored limb in primary motor- and somatosensory cortex. However, mirror boxes have some limitations which prompted the use of additional mirror visual feedback devices. The present study evaluated the utility of mirror glasses compared to a mirror box. We also tested the hypothesis that increased interhemispheric communication between the motor hand areas is the mechanism by which mirror visual feedback recruits the representation of the non-mirrored limb. Therefore, mirror illusion capacity and brain activations were measured in a within-subject design during both mirror visual feedback conditions in counterbalanced order with 20 healthy subjects inside a magnetic resonance imaging scanner. Furthermore, we analyzed task-dependent functional connectivity between motor hand representations using psychophysiological interaction analysis during both mirror tasks. Neither the subjective quality of mirror illusions nor the patterns of functional brain activation differed between the mirror tasks. The sensorimotor representation of the non-mirrored hand was recruited in both mirror tasks. However, a significant increase in interhemispheric connectivity between the hand areas was only observed in the mirror glasses condition, suggesting different mechanisms for the recruitment of the representation of the non-mirrored hand in the two mirror tasks. We conclude that the mirror glasses might be a promising alternative to the mirror box, as they induce similar patterns of brain activation. Moreover, the mirror glasses can be easy applied in therapy and research. We want to emphasize that the neuronal mechanisms for the recruitment of the affected limb representation might differ depending on conceptual differences between MVF devices. However, our findings need to be validated within specific patient groups.
Over-expression of CD200 protects mice from dextran sodium sulfate induced colitis (P3286) (2013)

Abstract CD200:CD200R interactions have been shown to lead to potent immunosuppression, resulting in enhanced allograft survival; reduced collagen-induced arthritis; and increased growth of leukemic, lymphoma cells and breast cancer cells. We have investigated the effect of "knockout"of CD200R, or over-expression of CD200 in transgenic mice (CD200tg), on susceptibility to dextran sodium sulfate (DSS) induced colitis in C57BL/6 female mice. Control animals given DSS developed weight loss (~15%) and diarrhoea over 7 days, before slow recovery. These effects were more pronounced in CD200RKO mice, with ~40% mortality at day 7. In contrast CD200tg mice showed attenuation of all symptoms. Immunohistological analysis and protein expression array confirmed severe inflammation in CD200RKO and controls, with loss of villi, inflitration by macrophages, neutrophils and CD3+ cells, and high expression levels of IL-1β and TNF-α in the intestine. In CD200tg mice intestinal tissue showed enhanced inflitration by Foxp3+Tregs, with increased expression of IL-10. Taken together these data suggest for the first time that CD200:CD200R interactions play a role in regulating inflammatory colitis in mice, which may open new avenues for treatment of inflammatory diseases in man.
In-band quantum key distribution (QKD) on fiber populated by high-speed classical data channels (2006)

We used a commercial QKD system to conduct key exchange over 50-km fiber span that supported classical 10 Gbit/sec traffic. Both quantum and classical channels were carried by the standard ITU grid C-band wavelengths.
Investigation of pressure drop in a cocurrent downflow three‐phase moving bed (2020)

Abstract Based on a self‐established cold‐flow experimental device, the pressure drop in a cocurrent downflow three‐phase moving bed was investigated under a wide range of gas, liquid, and solid flow rates during dynamic and steady‐state operation. The results showed that for the startup of the bed, since the first bed layer packed by fall‐falling of particles had lower voidage, it would take at least one bed volume time to make the voidage in the bed reach the steady‐state. Under steady‐state conditions, the pressure drop increased with the increase of gas and liquid mass flow rates, liquid viscosity, and decreased with the increase of solid flow rate. Furthermore, it was found that the liquid distribution became more uniform due to particle movement. The experimental data obtained in this study was used to develop a correlation to predict the pressure drop in a three‐phase moving bed with an average relative error of 9.32%.
Synthesis and Characterization of New Platinum(II) and Platinum(IV) Triphyrin Complexes (2013)

Metalation of 6,13,20,21-tetrakis(4-methylphenyl)-22H-tribenzo[14]triphyrin(2.1.1) with PtCl(2) gave a platinum(II) complex having a square-planar coordination structure with two pyrrolic nitrogen atoms and two chloride ions, with a saddle-shaped macrocycle. This platinum(II) complex was easily oxidized by air to an octahedral platinum(IV) complex coordinated by three pyrrolic nitrogen atoms as a tridentate monoanionic cyclic ligand and three chloride ions. When platinum(II) triphyrin was crystallized in air, an oxygen atom was incorporated between two α-carbon atoms of the pyrroles as an oxygen bridge to intercept the 14π aromatic system.
Lung cancer breath tests (2019)

The current letter describes the rational behind breath analysis of lung cancer and the progress made so far by means of mass spectrometry and smart sensor arrays. Additionally, it presents and discusses the potential of breath analysis in enabling inexpensive and non-invasive technology that would allow efficient early detection of cancer; stratifying the population based on their bio-specification for a tailored (personalized) therapy; and bed-side fast assessment of treatment efficacy in order to change the therapeutic approach. At the end, the letter pinpoints the main implementation strengths of the method as a routine diagnostic and monitoring in the digital era.
Evanescent-mode cavity-based frequency synthesizer (2016)

An evanescent-mode (EVA) cavity-based frequency synthesizer is developed, implemented, and experimentally validated. The oscillator is integrated on the same substrate of a high-Q (Q <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">u</inf> ≥ 400) EVA resonator board to reduce parasitics in the circuit. A piezoelectric actuator is used as a tuner. A phase-locked loop (PLL) is used to control the output frequency. The frequency tuning range is 610 MHz to 950 MHz (1:1.55). The circuit also achieves a phase noise as low as −104 dBc/Hz at 100 kHz offset, −144 dBc/Hz at 1 MHz offset, and − 150 dBc/Hz as a noise floor. The RMS jitter of the system is 3 ps, and the peak-to-peak jitter is 13 ps at 700 MHz. The frequency synthesizer consumes 340 mW.
Frequency Dependency Analysis of SHF band Directional Propagation Channel in Indoor Environment (2018)

In the fifth-generation mobile communication system (5G), the millimeter wave band wireless communication is highly expected that it increases the network capacity drastically. The radio propagation characteristics in the millimeter wave band are thought to be quite different from the microwave band that has been used for the current mobile wireless communication. And it is needed to clarify those differences in a comparative way for investigating the feasibility of millimeter wave communication system in the actual environment. Author's research group has conducted channel measurements in several super high frequency (SHF) bands and investigated the frequency characteristics of the propagation channel to solve the issue. In this paper, we conducted the channel measurements in 3 GHz, 10 GHz and 28 GHz bands in a small room environment. The delay and both the azimuth and the elevation directional characteristics of the channels were investigated by using the virtual cylindrical array. The results showed that not only the reflection from walls but also the reflections from the floor and the ceiling were also significant in the early propagation delay region. The results are expected to be utilized for the system deployment of millimeter wave communication system.
Differential Use of Rap1 Effectors for Integrin Activation in Platelets and Lymphocytes (2020)

Rap1 is a major convergence point of the platelet and lymphocyte signaling pathways that result in talin1 binding to the integrin β-cytoplasmic domain and consequent integrin activation, effective hemostasis and immune functions. The nature of the connection between Rap1 and talin1 in integrin activation is an important remaining gap in our understanding of this process. Deletion of RIAM in T cells partially suppressed αLβ2 and α4β7 integrin activation but did not block activation of α4β1. In sharp contrast, deletion of both Rap1a and Rap1b isoforms or deletion of talin1 profoundly suppressed activation of α4β1 in addition to the other two integrins. The loss of homing of T cells to peripheral lymphoid organs was correlated with the loss of integrin activation in these mutant T cells. We recently identified two Rap1 binding sites in talin1 F0 and F1 domains and generated mice bearing point mutations, which block Rap1 binding to both talin1 F0 and F1 domains (R35E,R118E). In platelets, which lack endogenous RIAM, a talin1 (R35E,R118E) mutation suppresses activation of integrin αIIbβ3 and platelet aggregation to a similar extent to that observed in Rap1a,b null platelets. In contrast, talin1 (R35E,R118E)-expressing T cells manifest only partial loss of integrin activation, whereas RIAM null T cells expressing talin1 (R35E,R118E) exhibit a much more profound defect. Importantly, overexpression of RIAM can completely rescue the integrin activation defect in talin1 (R35E,R118E)-expressing T cells indicating that Rap1 binding to RIAM and talin1 are partially redundant in T cells. These findings reveal that although both Rap1 and talin1 are essential for integrin action in blood cells, the connections between them vary in different blood cells and that the final steps in integrin activation and blood cell function can be manipulated in a cell-type specific manner. Disclosures No relevant conflicts of interest to declare.