gebhart/patrepeval huggingface dataset:
Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. (1998)

The new neuropeptide Y (NPY) Y5 receptor antagonist CGP 71683A displayed high affinity for the cloned rat NPY Y5 subtype, but > 1, 000-fold lower affinity for the cloned rat NPY Y1, Y2, and Y4 subtypes. In LMTK cells transfected with the human NPY Y5 receptor, CGP 71683A was without intrinsic activity and antagonized NPY-induced Ca2+ transients. CGP 71683A was given intraperitoneally (dose range 1-100 mg/kg) to a series of animal models of high hypothalamic NPY levels. In lean satiated rats CGP 71683A significantly antagonized the increase in food intake induced by intracerebroventricular injection of NPY. In 24-h fasted and streptozotocin diabetic rats CGP 71683A dose-dependently inhibited food intake. During the dark phase, CGP 71683A dose-dependently inhibited food intake in free-feeding lean rats without affecting the normal pattern of food intake or inducing taste aversion. In free-feeding lean rats, intraperitoneal administration of CGP 71683A for 28 d inhibited food intake dose-dependently with a maximum reduction observed on days 3 and 4. Despite the return of food intake to control levels, body weight and the peripheral fat mass remained significantly reduced. The data demonstrate that the NPY Y5 receptor subtype plays a role in NPY-induced food intake, but also suggest that, with chronic blockade, counterregulatory mechanisms are induced to restore appetite.
Using Vector Correlation To Probe the Influence of Vibrational State Selection on the Photodissociation Dynamics of HN3 (1997)

State-selected photodissociation of hydrozoic acid is investigated by vibrationally exciting the molecule in the region of the second overtone of its N−H stretching motion (3ν1) and then photodissociating it using 532 nm light. Measurement of the resulting NH fragment rotational state distribution and vector correlation reveals that photodissociation from initial nuclear configurations with an extended N−H bond leads to a substantially hotter rotational state distribution as well as a more pronounced 〈v⃗,j⃗〉 correlation than from nearly isoenergetic single-photon dissociation at 355 nm. These observations are interpreted as indicating that the region of the excited electronic surface accessed and hence the forces experienced by the molecule are different in the two isoenergetic photodissociation experiments.
A Highly Active Anilinotropone-Based Neutral Nickel(II) Catalyst for Ethylene Polymerization (2001)

The synthesis of a neutral nickel(II) complex of 2-(2,6-diisopropylanilino)tropone is described. The important attributes of this ligand include a hindered N-aryl ring, a five-membered-ring chelate, and an anionic N-donor. The complex has been characterized in the solid state by X-ray crystallography, and relevant features are discussed. The nickel complex is capable of polymerizing ethylene with a turnover frequency of up to 8.8 × 106 g of PE (mol of catalyst)-1 h-1 and of producing polyethylenes with a wide range of branching numbers by changes in pressure and temperature. The catalyst shows an excellent tolerance for polar additives in ethylene polymerization experiments and is quite insensitive to added PPh3.1
Three-phase unidirectional DELTA-switch multistate switching cells-based multilevel rectifier (2015)

This work presents a unidirectional three-phase PFC rectifier well-suited for applications targeting high efficiency, reduced conducted emissions and/or high power density. The characteristics of this circuit, which is based on the paralleling of DELTA-switch rectifiers by means of interphase transformers, including the principles of operation, modulation strategy, suitable PFC-oriented control scheme, and dimensioning equations are described in this work. Finally, a prototype is presented and experimental results verify the main characteristics of the proposed converter.
Evaluation of roughness transfer from Litho to Etch using CD-SEM (2012)

Roughness transfer from Litho to Etch has been evaluated. The impact of Line width roughness (LWR) or Line edge roughness (LER) is getting larger with shrink of semiconductor devices. In this study, the roughness measurement by using a single frame SEM image was brought in to avoid resist shrinkage, and image enhance technique is used to compensate low S/N ratio in this one frame image. CD-AFM was used as reference, and LWR measured by CD-AFM was compared to the results of one frame enhanced image taken by CD-SEM. And roughness spectrum analysis was used for evaluation of roughness characteristics taken by CD-SEM and CD-AFM, and its transition by resist shrink or by etching process. It was enabled to observe the resist roughness profile with minimum shrink by using one frame enhanced image, then roughness transfer between Litho and Etch was evaluated by comparing in exactly the same position as pre- and post-etch. As a result, it was confirmed that transferred roughness by etching was remaining the peak and valley profile in resist observed by CD-SEM, but the roughness amplitude was reduced in higher frequency domain. This result consists with the roughness characteristics comparison from Litho to Etch. This also means roughness characteristics analysis shows the actual nanoscopic event.
Response to “Comment on ‘Two pathways for photon upconversion in model organic compound systems’ [J. Appl. Phys. 101, 023101 (2007)]” (2007)

We have studied the phenomenon of photon upconversion in systems of two model compounds as highly efficient blue emitters sensitized with metallated macrocycle molecules in thin films. Aggregation between the active molecules (metallated porphyrins and anthracene derivatives) indeed plays a very important role in the triplet-triplet annihilation supported photon upconversion process. Contrary to the suggestions of Steer [J. Appl. Phys. 102, 076102 (2007)] aggregation (followed from phase separation) is a highly undesired effect: external quantum yields of the level of 1%–3% are observed only in systems with a low degree of aggregation (solutions), whereas the solid state films exhibit at least order of magnitude lower upconversion quantum yield than solutions. Additionally, the “only excitons in aggregates model” cannot explain the increase of the linear absorption of the sensitizer at the presence of the emitter. Furthermore, this hypothesis cannot explain why the upconversion quantum yield increases when decreasing the total molecular concentration. Finally, the only excitons in aggregates model needs to assume equal aggregation properties of molecules with different solubilities, sizes, and decorations, as the case of PdPh4TBP and PdPh4OMe8TNP.
Abstract 1834: Constitutive Nedd9 null genotype promotes lung cancer aggressiveness (2017)

Abstract Non-small cell lung cancer (NSCLC) has a low survival rate, with metastasis contributing to the vast majority of deaths. The NEDD9 (HEF1/Cas-L) protein has been reported to be elevated in expression and to promote metastasis in a large subset of lung cancers and in other malignancies. NEDD9 functions as a scaffold for multiple critical effectors in integrin/FAK/SRC and receptor tyrosine kinase signaling cascades, as well as for the mitotic kinase Aurora-A, with overexpression thought to sustain signaling by these pro-oncogenic proteins. Previous studies demonstrated depletion of NEDD9 by RNAi reduced the growth and invasion of established lung cell lines and tumors, based on cell culture and xenograft assays. We have now investigated the consequences of a null genotype for Nedd9 from the earliest stages of tumor formation, crossing Nedd9 null mice to a 129S/Sv-Krastm3Tyj/Trp53tm1Brn (KP) model in which Kras mutation is induced specifically in lung tissue by inhalation of adenovirus bearing the Cre gene. Unexpectedly, based on in vivo imaging, the Nedd9 null genotype significantly accelerated tumor growth in KP mice. Pathological examination of tissues indicated Nedd9 null genotype also was associated with higher invasive capacity in vivo, including direct invasion to the heart, as well as elevated proliferation rate, decreased apoptotic activity, and changes in the expression of proteins such as vimentin, associated with mesenchymal status. Although Nedd9 function has been implicated in immune cell activity, we found minimal differences in tumor infiltration of myeloid cells or macrophages based on Nedd9 genotype. Rather, use of Reverse Phase Protein Array (RPPA) analysis to characterize signaling in isolated tumors suggested tumor intrinsic changes in glycolytic and proliferative signaling pathways, which were subsequently validated using direct functional assays. These results for the first time imply that NSCLC tumor progression beyond early stages in the absence of Nedd9 requires reprogramming of intrinsic tumor signaling to compensate for the absence of this protein, emphasizing activities distinct from those associated with elevated Nedd9 in late stage tumors. Citation Format: Alexander Deneka, Meghan Kopp, Anna S. Nikonova, Anna Gaponova, Alexandra Nagele, Harvey Hensley, Erica Golemis. Constitutive Nedd9 null genotype promotes lung cancer aggressiveness [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1834. doi:10.1158/1538-7445.AM2017-1834
FPGA-Based Implementation of Torque Controller for 6-DOF Articulated Robots (2021)

Abstract This paper aims to design an impedance position-based proportional-integral-derivative (PID) controller based on forward and inverse kinematics of HIWIN RA605 articulated robot, and Field-Programmable Gate Array (FPGA) implementation for a PID torque controller. In order to control the robot, the FPGA needs to output commands to communicate with the AC servo motor drivers. An FPGA-based controller for a 6-degree-of-freedom (DOF) articulated robot that implements several tasks such as hardware implementation, encoder counters, noise cancellation algorithm, analog generators, PID controller, and communication are included, the processing time of the FPGA is 16 μs. Meanwhile, the whole process of the system only takes 82 μs to complete.
PHOSPHATE MATERIALS FOR RECHARGEABLE BATTERY APPLICATIONS (2013)

Phosphate materials are becoming more important as cathodes and electrolytes in electrochemical energy conversion devices. This review provides an overview of the recent advances in phosphate materials chemistry for lithium ion batteries. The synthesis and processing technologies are particularly focused to provide practical ways to develop advanced lithium ion batteries with high safety.
Wideband Cyclostationary Signal Processing Using Sparse Subsets of Narrowband Subchannels (2018)

The problem of signal detection and modulation recognition is addressed in both the blind and nonblind contexts. Many relevant modulation recognition algorithms have been created over the past three decades. The essential engineering tradeoff that fuels the algorithm-invention process is between generality and optimality. Optimal (e.g., maximum-likelihood) algorithms can be devised for narrow subsets of signal types, whereas highly general but suboptimal feature-based algorithms can be devised for wide subsets of types. It has previously been shown that cyclostationary-based classifiers possess highly desirable properties, such as tolerance to noise and cochannel interference, but also that they are computational costly and so are resistant to real-time hardware implementation. In this paper, we present a reduced-complexity method of signal detection and modulation recognition that exploits the cyclostationarity of over-the-air observed communication signals. The key idea is to represent wideband input data as a set of narrowband, contiguous, nonoverlapping subchannels, and then to extract the desired cyclostationary features for the wideband data using only sparse subsets of the subchannels.
Dry development of sub-0.25 μm features patterned with 193 nm silylation resist (1996)

The dry development of sub-0.25 μm silylated resist features patterned at 193 nm was optimized in an oxygen plasma using a high-ion-density plasma etcher. Low pressure and low wafer temperature eliminate lateral resist loss, resulting in vertical profiles, linewidth fidelity, and large process latitudes for 0.175 μm silylated resist features.
Supplementary Table Legends from Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer (2023)

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Direct pulsed laser crystallization of nanocrystals for absorbent layers in photovoltaics: Multiphysics simulation and experiment (2013)

Direct pulsed laser crystallization (DPLC) of nanoparticles of photoactive material—Copper Indium Selenide (nanoCIS) is investigated by multiphysics simulation and experiments. Laser interaction with nanoparticles is fundamentally different from their bulk counterparts. A multiphysics electromagnetic-heat transfer model is built to simulate DPLC of nanoparticles. It is found smaller photoactive nanomaterials (e.g., nanoCIS) require less laser fluence to accomplish the DPLC due to their stronger interactions with incident laser and lower melting point. The simulated optimal laser fluence is validated by experiments observation of ideal microstructure. Selectivity of DPLC process is also confirmed by multiphysics simulation and experiments. The combination effects of pulse numbers and laser intensity to trigger laser ablation are investigated in order to avoid undesired results during multiple laser processing. The number of pulse numbers is inversely proportional to the laser fluence to trigger laser ablation.
Does Interleukin-6 Bridge SARS-CoV-2 With Virus-Associated Cancers? (2021)

To date SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), a member of the Coronaviridae family, has infected more than 40 million people worldwide. A second wave of SARS-CoV-2 infection is aggressively surging. The clinical worsening of SARS-CoV-2 infection appears to be strictly associated with comorbidities, which can be used to establish an intrinsic patient network whose molecular profile is pivotal for identifying and successfully treating populations at risk. Herein, we focus on the direct interaction between SARS-CoV-2 and virus-associated cancers, exploring the critical role of interleukin-6 (IL-6) as a mediator of this complex cross talk. IL-6 production is enhanced in diverse viral infections ranging from human papilloma virus (HPV) to hepatitis B virus (HBV), human immunodeficiency virus (HIV), and SARS-CoV-2 infection. High systemic levels of IL-6 are associated with viral persistence and poor clinical outcomes in SARS-CoV-2-infected patients. Blockade of IL-6/IL-6R, using specific molecules, is under investigation in active clinical trials for the treatment of patients with SARS-CoV-2. Although the data are as yet inconclusive, they pave the way for selective targeting of crucial cytokine-activated aberrant signaling in SARS-CoV-2 infection.
A Novel Testing for Post-peak Tensile Behavior of Cementitious Composites (1989)

Peer Reviewed
Isolation of Novel Bacteria Including Rarely Cultivated Phyla, <i>Acidobacteria</i> and <i>Verrucomicrobia</i>, from the Roots of Emergent Plants by Simple Culturing Method (2017)

A number of novel bacteria including members of rarely cultivated phyla, Acidobacteria and Verrucomicrobia, were successfully isolated from the roots of two emergent plants, Iris pseudacorus and Scirpus juncoides, by a simple culturing method. A total of 47.1% (66 strains) for I. pseudacorus and 42.1% (59 strains) for S. juncoides of all isolates (140 strains from each sample) were phylogenetically novel. Furthermore, Acidobacteria and Verrucomicrobia occupied 10.7% (15 strains) and 2.9% (4 strains) of I. pseudacorus isolates, and 2.1% (3 strains) and 3.6% (5 strains) of S. juncoides isolates, respectively, indicating that plant roots are attractive sources for isolating rarely cultivated microbes.
Supplementary Figure from BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors (2023)

Supplementary Figure from BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors
A fast iterative physical optics (FIPO) algorithm based on non‐uniform polar grid interpolation (2002)

Abstract In this paper, a novel fast iterative physical optics (FIPO) algorithm is proposed for analysis of scattering from electrically large objects involving multiple reflections such as the case for open‐ended cavities. At each iteration, the physical optics current induced on the surface of the scatterer produces a correction to the incident field, which in turn induces a correction to the physical optics current. The FIPO algorithm relies on fast field evaluation, which is achieved via domain decomposition of the scatterer surface and comprises two steps repeated for each subdomain. First, computation of the field is produced by currents residing within a subdomain over a sparse set of points surrounding the scatterer. Second, phase removal, interpolation, phase restoration, and aggregation of the field of the subdomain are integrated into the total field on the surface. The proposed approach can be extended to fast iterative solution of problems discretized via the method of moments. © 2002 Wiley Periodicals, Inc. Microwave Opt Technol Lett 35: 240–244, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10568
Dzyaloshinskii-Moriya anisotropy in nanomagnets with in-plane magnetization (2016)

We report on a source of in-plane anisotropy in nanomagnets due to the presence of Dzyaloshinskii-Moriya interaction (DMI). This anisotropy depends on the shape of the magnet, and is orthogonal to the demagnetization shape anisotropy. This effect originates from the DMI energy reduction due to an out-of-plane tilt of the spins at edges oriented perpendicular to the magnetization. Our numerical and analytical investigations demonstrate that this energy reduction can compensate the demagnetization shape anisotropy energy in magnets of elongated shape, provided that their volumes are small enough and thus that their magnetization is quasiuniform. Our model agrees quantitatively with magnetic force microscopy observations on preliminary sub-100-nm structures.
Diffractive Optical Elements for AQUARIUS . (2020)

Abstract not provided.
Topical Review: Families Coping With Child Trauma: A Naturalistic Observation Methodology (2015)

Naturalistic observation methods such as the EAR have potential for pediatric psychology studies regarding trauma and the family environment.
Distributed Firewall For MANETs (2008)

Mobile Ad-hoc Networks (MANETs) are increasingly used in military tactical situations and in civil rapid-deployment networks, including emergency rescue operations and {\it ad hoc} disaster-relief networks. The flexibility of MANETs comes at a price, when compared to wired and basestation-based wireless networks: MANETs are susceptible to both insider (compromised node) and outsider attacks due to the lack of a well-defined perimeter in which to deploy firewalls, intrusion detection systems, and other mechanisms commonly used for network access and admission control. In this paper, we define a distributed firewall architecture that is designed specifically for MANETs. Our approach harnesses and extends the concept of a {\it network capability}, and is especially suited for environments where the communicating nodes have different roles and hence different communication requirements, such as in tactical networks. Our model enforces communication restrictions among MANET nodes and services, allowing hop-by-hop policy enforcement in a distributed manner. We use a ''deny-by-default'' model where compromised nodes have access only to authorized services, without the ability to disrupt or interfere with end-to-end service connectivity and nodes beyond their local communication radius. Our simulations show that our solution has minimal overhead in terms of bandwidth and latency, works well even in the presence of routing changes due to mobile nodes, and is effective in containing misbehaving nodes.
Regulation of nuclear superoxide production in mouse liver (2011)

Redox-regulated signal transduction requires spatially controlled production of reactive oxygen species in subcellular compartments. The nucleus has long been known to produce superoxide (O2•−); however, the mechanisms that control this function remain largely unknown. We have characterized molecular features of a nuclear superoxide-producing system in mouse liver. Using electron paramagnetic resonance, we investigated whether several NADPH oxidases and known activators of NOX contribute to nuclear O2•− production in isolated hepatic nuclei. We showed that NOX4 most significantly contributes to nuclear O2•− production that utilizes NADPH as an electron donor. Although NOX4 protein immunolocalized to both nuclear membranes and intranuclear inclusions, fluorescent detection of NADPH-dependent nuclear O2•− predominantly localized to the perinuclear space. NADP+ and G6P also induced nuclear O2•− production, suggesting that intranuclear glucose 6-phosphate dehydrogenase (G6PD) controls NOX4 activity through nuclear NADPH production. Using G6PD-mutant mice and G6PD shRNA, we confirmed that reductions in nuclear G6PD decrease the ability of hepatic nuclei to generate O2•− in response to NADP+ and G6P. NOX4 and G6PD partly co-localize within the nucleus. These findings provide new insights on the metabolic pathways for substrate regulation of nuclear O2•− production by NOX4. Support: NIH.
Traces to the oldest flint and rock crystal mining places in the Austrian Alps (2010)

Recently the Institute of Archaeology (Dep. of Pre- and Protohistory) of the University of Innsbruck has undertaken excavation work in the Kleinwalsertal (Vorarlberg). Actually all sites and finds belong to the Mesolithic period. The lithic artefacts are made to a large extend from a red and green radiolarite which has been mined in the very close surroundings. Finds of corresponding raw material in the river gravel of the valley led to the primary layers on precipitous slopes in an altitude of 1600 meters. This place can therefore be defined as the oldest and highest mining site in the Alps. From the actual explorations we can deduce that the so called fresh raw material was stroken off in form of steps. In 2007 a mining tool corresponding to a stone-hammer could be found. The raw-material is of good quality and the localized rich natural deposits in this area permits a kind of small supplying center for the western region of Austrian Alps in the Mesolithic age. Other studies were conducted in the Lechtaler Alps and in the Rofan Mountains in the upper and respectively in the lower Inn Valley of the Tyrol. There Silex resources appear in great quantities so that prehistoric mining is to be expected. Further exploration work is done in the Tuxer Alps where big quartz clefts show traces of prehistoric extractions of rock-crystal.
Proposal of a new medical manipulator for laparoscopic surgery (2001)

Click to increase image sizeClick to decrease image sizeKeywords: MINIMALLY INVASIVE SURGERYLAPAROSCOPIC SURGERYMASTER-SLAVE MANIPULATORROBOTIC TOOL
CJASN Matures to a Monthly Journal (2009)

Starting with the current issue, Clinical Journal of the American Society of Nephrology will now be published monthly. The primary reason for this change is the large number of excellent manuscripts regarding clinical nephrology that are being submitted for publication from around the world. From 2006 through 2008, CJASN was published bimonthly, and each successive issue progressively expanded to accommodate the large and growing number of manuscripts that are accepted after our rigorous peer review process. Although extremely pleased with the growth of …