gebhart/patrepeval huggingface dataset:
A one-year prospective study of the safety,tolerability and pharmacokinetics of the highestavailable dose of paliperidone palmitate inpatients with schizophrenia (2012)

Background: There are no previous reports of paliperidone palmitate’s (PP) long term tolerability or pharmacokinetics of the highest dose in patients with schizophrenia. This study evaluates safety and tolerability, as well as pharmacokinetics, of the highest marketed dose of PP (150 mg eq. [234 mg]) in stable patients with schizophrenia over a 1-year period.
Methods: In this 1-year prospective study, eligible patients (aged 18-65 years; Positive and Negative Syndrome
Scale’s total score ≤ 70) received an initial deltoid injection of PP 150 mg eq. The second injection one week later and subsequent once-monthly injections were deltoid or gluteal. All injections were to be PP 150 mg eq. Patients
willing to participate in intensive pharmacokinetic sampling were classified as Treatment A. Patients unwilling to undergo intensive pharmacokinetic sampling or unable to tolerate the 150 mg eq. dose (consequently receiving
flexible doses of 50, 100 or 150 mg eq.) were classified as Treatment B.
Results: Of the 212 patients (safety analysis set), 73% were men; 45% white; 20% black; 34% Asians; mean (SD) age
41 (10.2) years, and mean (SD) baseline Positive and Negative Syndrome Scale total score 54.9 (9.03). A total of 53% (n = 113) patients completed the study and 104 received PP 150 mg eq. throughout. Mean (SD) mode dose of PP
was 144.8 (19.58) mg eq. The dosing initiation regimen resulted in rapidly achieved and maintained therapeutic
paliperidone levels over the study (average concentrations during the dosing interval were 34.7, 40.0, and 47.8 ng/
mL after the 2nd, 8th, and 14th injection respectively). Most frequent (≥ 10%) treatment-emergent adverse events
were nasopharyngitis (n = 37), insomnia (n = 32), injection-site pain (n = 32), headache (n = 28), and tachycardia (n= 27). Akathisia (n = 19) and tremor (n = 11) were the most common extrapyramidal adverse events. 33 patients had an SAE and 27 discontinued due to treatment-emergent adverse events. No deaths were reported. Mean (SD)
weight change from baseline was 2.5 (5.41) kg at endpoint. Patients’ psychoses remained stable.
Conclusions: Safety results after one-year therapy with the highest available dose of once-monthly paliperidone
palmitate were consistent with results from previous studies, with no new concerns noted. Plasma concentrations
were within the expected range.
ChemInform Abstract: Zirconocene‐Mediated Cyclization of 2‐Bromo α,ω‐Dienes. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Étude d’un moteur supraconducteur à flux axial avec une transmission magnétique supraconductrice intégrée (2015)

Chapitre Les supraconducteurs dans les machines tournantesAn axial-field HTS motor with integrated magnetic coupling has been also designed, constructed and tested.The test results have been checked by 3D finite element computations.
Dynamic Sunlight Filter (DSF): a passive way to increase the dynamic range in visible and SWIR cameras (2010)

Regulating optical power levels within various systems, such as cameras, requires today an electronic feedback control or offline data processing, which introduces complex and expensive systems. Sometimes the blooming is such that data is lost and cannot be recovered by any sophisticated software. We explore the unique capabilities and advantages of nanotechnology in developing next generation non-linear components and devices to control and regulate optical power in a passive way. We report on the Dynamic Sunlight Filter (DSF) enabling High Dynamic Range (HDR) for various types of camera. The DSF solution is completely passive and can be added to any camera as an external add-on.
Physical Activity and Sleep Patterns in Hemodialysis Patients in a Suburban Environment (2017)

Patients in a suburban environment walked much less than those in a previously studied urban population. They rarely met the recommended goal of 10,000 steps/day, even on non-dialysis days. Interventions to increase physical activity may target any day of the week, particularly HD days. Prospective, long-term studies are needed to evaluate the use of activity trackers in dialysis patients and their impact on physical activity.
FAPI Controller for Frequency Support in Low-Inertia Power Systems (2020)

This paper presents different forms of Fast Active Power Injection (FAPI) control schemes for the analysis and development of different mitigation measures to address the frequency stability problem due to the growth of the penetration level of the Power Electronic Interfaced Generation (PEIG) in sustainable interconnected energy systems. Among the studied FAPI control schemes, two different approaches in the form of a derivative-based control and a virtual synchronous power (VSP) based control for wind turbine applications are also proposed. All schemes are attached to the PEIG represented by a generic model of wind turbines type 4. The derivative-based FAPI control is applied as an extension of the droop based control scheme, which is dependent on the measurement of the network frequency. By contrast, the proposed VSP-based FAPI is fed by the measurement of the active power deviation. Additionally, unlike existing approaches for virtual synchronous machines, which are characterized by high-order transfer functions, the proposed VSP-based FAPI is defined by a second-order transfer function, which can contribute to fast mitigation of the system primary frequency deviations during containment period. The Great Britain (GB) test system, for the Gone-Green planning scenario for the year 2030 (GG2030), is used to evaluate the effects of the proposed FAPI controllers on the dynamics of the system frequency within the frequency containment period. Thanks to proposed FAPI controllers, it is possible to reach up to 70% for the share of wind power generation without violating the threshold limits for frequency stability. For verification purposes, a full-scale wind turbine facilitated with each FAPI controller is tested in EMT real-time simulation environment.
Data associated the publication: Static polystyrene gate charge density modulation of dinaphthothienothiophene with tetrafluorotetracyanoquinodimethane layer doping: Evidence from conductivity and Seebeck coefficient measurements and correlations (2020)

We relate the static charging of organic field effect transistor (OFET) gate dielectric polymers, the resulting change in threshold voltage shift, and the modulation of thermoelectric properties of the transistor semiconductor. We utilize a bottom gate OFET structure with cross-linkable polystyrene and plain polystyrene (XLPS/PS) bilayer dielectrics and dinaphthothienothiophene (DNTT) organic molecular semiconductor with tetrafluorotetracyanoquinodimethane (F4TCNQ) doping layer. The conductivity and Seebeck coefficient are measured before and after charging. We find that the conductivity increases significantly, while the Seebeck coefficient decreases correspondingly in a trend of S ∝ ln(σ) after the dielectrics were negatively charged, resulting in an average of 5-fold increase in power factor at the maximum charging level. Additionally, temperature-dependent conductivity measurements show that the activation energy decreases with the increasing conductivity. We calculate the Seebeck coefficient based on the activation energy and find the result is consistent with the Mott mobility edge model. This work confirms the charging mechanism in our previous published work, including the location of static charges in the bulk of the dielectric, and demonstrates modulation and enhancement of the thermoelectric properties of organic thermoelectric materials by adjacent chargeable dielectrics without changing the molecular microstructure or applying external gate voltage during operation.
Synthesis and Biological Evaluation of Bis-CNB-GABA, a Photoactivatable Neurotransmitter with Low Receptor Interference and Chemical Two-Photon Uncaging Properties (2014)

Photoactivatable "caged" neurotransmitters allow optical control of neural tissue with high spatial and temporal precision. However, the development of caged versions of the chief vertebrate inhibitory neurotransmitter, γ-amino butyric acid (GABA), has been limited by the propensity of caged GABAs to interact with GABA receptors. We describe herein the synthesis and application of a practically useful doubly caged GABA analog, termed bis-α-carboxy-2-nitrobenzyl-GABA (bis-CNB-GABA). Uncaging of bis-CNB-GABA evokes inward GABAergic currents in cerebellar molecular layer interneurons with rise times of 2 ms, comparable to flash duration. Response amplitudes depend on the square of flash intensity, as expected for a chemical two-photon uncaging effect. Importantly, prior to uncaging, bis-CNB-GABA is inactive at the GABAA receptor, evoking no changes in holding current in voltage-clamped neurons and showing an IC50 of at least 2.5 mM as measured using spontaneous GABAergic synaptic currents. Bis-CNB-GABA is stable in solution, with an estimated half-life of 98 days in the light. We expect that bis-CNB-GABA will prove to be an effective tool for high-resolution chemical control of brain circuits.
Photochemically induced nuclear polarization probes for thiol groups in peptides and proteins (1983)

K. A. Jacobson, K. A. Muszkat and I. Khait, J. Chem. Soc., Chem. Commun., 1983, 1384 DOI: 10.1039/C39830001384
OMICS AND PROGNSTIC MARKERS (2013)

Although histopathological diagnosis is essential in decision of therapeutic strategy for gliomas, sometimes the tumors diagnosed in one histological entity show thoroughly different clinical courses. This phenomenon is believed to be due primarily to the presence of the genetic subgroup. In fact, relationship between treatment response and certain genetic characteristics is indicated (e.g. better chemosensitivity in glioma with losses of 1p/19q (21p/19q)). It is highly likely that genetic classification of glioma is useful to select the adjuvant treatment. Additionally, gain of 7q (+7q) and 21p/19q are early events in 2 distinct tumor lineages, astrocytic tumors and oligodendroglial tumors, respectively, and these tumors obtain additional genetic aberration (29p, 10q) with tumor progression. On the other hand, concerning the tumors without +7q or 21p/19q, little is known about clinically important genetic aberration. Therefore the study on such tumors could provide useful information for the prognosis prediction and the determination of treatment strategy. METHODS: We selected 39 cases of gliomas without +7q or 21p/19q from 200 adult supratentorial glioma cases surgically treated and analyzed chromosomal DNA copy number aberrations (CNAs) by comparative genomic hybridization (CGH) from 2005 to 2012. We correlated clinical features of these tumors with histological characteristics, CNAs and IDH1 status. RESULTS: The clinical course of gliomas without +7q or 21p/19q was not correlated with additional genetic aberration of -9p or 10q, which have been known as genetic markers for poor prognosis, and absence of +7q or 21p/ 19q was maintained at the time of recurrence. The tumors without +7q or 21p/19q showed relatively favorable prognosis although mutation of IDH1 was infrequent in these tumors (35.8 %). CONCLUSION: The gliomas without +7q or 21p/19q have clinical features distinct from the +7q and 21p/19q gliomas. Prognostic markers for each subgroups could help establish therapeutic strategy against the tumor.
ProVeR: Probabilistic Video Retrieval using the Gauss-Tree (2007)

Modeling objects by probability density functions (pdf) is a new powerful method to represent complex objects in databases. By representing an object as a pdf e.g. a Gaussian, it is possible to represent very large and complex objects in a compact and still descriptive way. In this contribution, we propose ProVeR a prototype search engine for content-based video retrieval which represents a video as a set of Gaussians. The Gaussians are managed by the Gauss-tree, an index structure allowing the efficient processing of probabilistic queries. ProVeR provides even non-expert users with an intuitive method for efficient, content-based retrieval of videos containing similar shots and scenes.
Hydrophobic cellulose nanocrystals modified with quaternary ammonium salts (2012)

An environmentally friendly procedure in aqueous solution for the surface modification of cellulose nanocrystals (CNCs) using quaternary ammonium salts via adsorption is developed as inspired by organomodified layered silicates. CNCs with a high carboxylate content of 1.5 mmol g−1 were prepared by a new route, direct hydrochloric acid hydrolysis of 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized nanofibrillated cellulose from a softwood pulp, and characterized by atomic force microscopy (AFM) and X-ray diffraction (XRD). Four quaternary ammonium cation surfactants bearing long alkyl, phenyl, glycidyl, and diallyl groups were successfully used to modify CNCs carrying carboxylic acid groups as characterized by Fourier transform infrared spectroscopy (FTIR). The modified CNCs can be redispersed and individualized in an organic solvent such as toluene as observed by scanning transmission electron microscopy (STEM). One may envision removing excess surfactant to obtain CNC with a monolayer of surfactant. The toluene suspension of the modified CNCs showed strong birefringence under crossed polars but no further chiral-nematic ordering was observed. The model surface prepared by the CNCs modified with quaternary ammonium salts bearing C18 alkyl chains showed a significant increase in water contact angle (71°) compared to that of unmodified CNCs (12°). This new series of modified CNCs can be dried from solvent and have the potential to form well-dispersed nanocomposites with non-polar polymers.
Biological upgrading of 3,6-anhydro-l-galactose from agarose to a new platform chemical (2020)

Recently, the utilization of renewable biomass instead of fossil fuels for producing fuels and chemicals is receiving much attention due to the global climate change. Among renewable biomass, marine algae are gaining importance as third generation biomass feedstocks owing to their advantages over lignocellulose. Particularly, red macroalgae have higher carbohydrate contents and simpler carbohydrate compositions than other marine algae. In red macroalgal carbphydrates, 3,6-anhydro-L-galactose (AHG) is the main sugar composing agarose along with D-galactose. However, AHG is not a common sugar and is chemically unstable. Thus, not only AHG but also red macroalgal biomass itself cannot be efficiently converted or utilized. Here, we biologically upgraded AHG to a new platform chemical, its sugar alcohol form, 3,6-anhydro-l-galactitol (AHGol), an anhydrohexitol. To accomplish this, we devised an integrated process encompassing a chemical hydrolysis process for producing agarobiose (AB) from agarose and a biological process for converting AB to AHGol using metabolically engineered <i>Saccharomyces cerevisiae</i> to efficiently produce AHGol from agarose with high titers and yields. AHGol was also converted to an intermediate chemical for plastics, isosorbide. To our knowledge, this is the first demonstration of upgrading a red macroalgal biomass component to a platform chemical via a new biological route, by using an engineered microorganism.
Liquid lens enabled optical coherence microscope with Gabor fusion (2010)

A custom optical microscope with an integrated liquid lens to enable an extended depth imaging in biological tissue has been fabricated and shown to provide subcellular resolution using Gabor image fusion in an optical coherence tomography setup. In this paper, we report on the development and assessment path of this technology over the last few years. Specifically, we report on the optical design as well as the MTF prediction and experimental measurements of the new optical microscope head. The microscope head was integrated in a custom optical coherence microscopy setup that is presented. Images of an African frog tadpole, <i>ex vivo</i> human breast excised tissue, and <i>in vivo</i> skin images, acquired with the integrated instrument, are presented.
Cavity ringdown detection of losses in thin films in the telecommunication wavelength window (2001)

The method of cavity ringdown spectroscopy (when a tunable pulsed optical parametric oscillator was used) was extended for the loss evaluation in thin films (2-20-microm thickness). The technique was applied in two key telecommunication wavelength ranges of 1260-1330 and 1480-1650 nm. The measurement sensitivity was determined to be 50 ppm (5 x 10(-5)). The results for polymer films are in close correlation with conventional spectrophotometric data and propagation loss for planar waveguides. Films of greater thickness and better optical quality are expected to provide an even higher loss resolution.
Pt/Ru Alloys Deposited by Sputtering and Atomic Layer Deposition as Catalysts for Methanol Oxidation (2008)

Abstract not Available.
FCFS SAVI: First-Come, First-Served Source Address Validation Improvement for Locally Assigned IPv6 Addresses (2012)

This memo describes FCFS SAVI a mechanism to provide source address
validation for IPv6 networks using the First-Come First-Serve
principle. The proposed mechanism is intended to complement ingress
filtering techniques to provide a finer granularity on the control of
the source addresses used.
Suppressive effect of antibody on processing of T cell epitopes. (1993)

Immunoglobulins drive efficient antigen capture by antigen presenting cells for processing and presentation on class II MHC-molecules. High affinity antibody/antigen interactions are stable at endosomal/lysosomal pH thus altering the substrate for antigen processing. We show that this can result in strong suppression of presentation of some T cell epitopes. This effect was observed when the antibody specificity was a B cell surface Ig, or formed part of an immune complex. In the latter case the presence of the suppressing antibody boosts presentation of other T cell epitopes through enhanced uptake into Fc receptor bearing cells. The influence of bound antibodies on the outcome of antigen processing may influence with T cell epitopes dominate T cell responses and may change the focus of the response with time.
Evaluation of malignant biliary obstruction: efficacy of fast multiplanar spoiled gradient-recalled MR imaging vs spin-echo MR imaging, CT, and cholangiography. (1994)

Contrast-enhanced FMPSPGR MR imaging is sensitive for the detection of tumors causing biliary obstruction. For proximal obstruction, it may be particularly effective for detecting and defining tumor extent of hilar cholangiocarcinomas because of their enhancement with gadopentetate dimeglumine. For cases of distal obstruction, this technique showed improved tumor detection and conspicuity compared with T1- and fast spin-echo T2-weighted images, but showed no advantage over CT.
Comparative study of power transmission modelling in large scale AGC power system (2013)

This paper presents a comparative analysis for various type of power transmission modeling in multi-area AGC power system. AC power transmission, parallel AC-AC transmission lines and parallel AC-DC transmission modeling in two-area LFC power system is presented and the results are compared. Based on simulation results the positive effects of HVDC links under random load disturbance are demonstrated.
CMOS-Compatible Multiple Wavelength Source (2009)

We demonstrate parametric oscillation in a complementary metal-oxide-semiconductor (CMOS) compatible silicon nitride ring resonator. We generate up to 40 wavelengths with a threshold power as low as 50 mW.
Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth (2013)

Mutations in the Tar DNA binding protein of 43 kDa (TDP-43; TARDBP) are associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43(+) inclusions (FTLD-TDP). To determine the physiological function of TDP-43, we knocked out zebrafish Tardbp and its paralogue Tardbp (TAR DNA binding protein-like), which lacks the glycine-rich domain where ALS- and FTLD-TDP-associated mutations cluster. tardbp mutants show no phenotype, a result of compensation by a unique splice variant of tardbpl that additionally contains a C-terminal elongation highly homologous to the glycine-rich domain of tardbp. Double-homozygous mutants of tardbp and tardbpl show muscle degeneration, strongly reduced blood circulation, mispatterning of vessels, impaired spinal motor neuron axon outgrowth, and early death. In double mutants the muscle-specific actin binding protein Filamin Ca is up-regulated. Strikingly, Filamin C is similarly increased in the frontal cortex of FTLD-TDP patients, suggesting aberrant expression in smooth muscle cells and TDP-43 loss-of-function as one underlying disease mechanism.
Antiangiogenic Arming of an Oncolytic Vaccinia Virus Enhances Antitumor Efficacy in Renal Cell Cancer Models (2009)

Oncolytic vaccinia viruses have shown compelling results in preclinical cancer models and promising preliminary safety and antitumor activity in early clinical trials. However, to facilitate systemic application it would be useful to improve tumor targeting and antitumor efficacy further. Here we report the generation of vvdd-VEGFR-1-Ig, a targeted and armed oncolytic vaccinia virus. Tumor targeting was achieved by deletion of genes for thymidine kinase and vaccinia virus growth factor, which are necessary for replication in normal but not in cancer cells. Given the high vascularization typical of kidney cancers, we armed the virus with the soluble vascular endothelial growth factor (VEGF) receptor 1 protein for an antiangiogenic effect. Systemic application of high doses of vvdd-VEGFR-1-Ig resulted in cytokine induction in an immunocompromised mouse model. Upon histopathological analysis, splenic extramedullary hematopoiesis was seen in all virus-injected mice and was more pronounced in the vvdd-VEGFR-1-Ig group. Analysis of the innate immune response after intravenous virus injection revealed high transient and dose-dependent cytokine elevations. When medium and low doses were used for intratumoral or intravenous injection, vvdd-VEGFR-1-Ig exhibited a stronger antitumor effect than the unarmed control. Furthermore, expression of VEGFR-1-Ig was confirmed, and a concurrent antiangiogenic effect was seen. In an immunocompetent model, systemic vvdd-VEGFR-1-Ig exhibited superior antitumor efficacy compared to the unarmed control virus. In conclusion, the targeted and armed vvdd-VEGFR-1-Ig has promising anticancer activity in renal cell cancer models. Extramedullary hematopoiesis may be a sensitive indicator of vaccinia virus effects in mice.