gebhart/patrepeval huggingface dataset:
206-LB: Indian Americans as Compared with Indians Exhibit Increased Beta-Cell Responsivity and Insulin Clearance in Absence of Changes in Insulin Sensitivity (2021)

Studies suggest that Indian Americans (IA) living in US have higher basal insulin resistance than other ethnic groups thereby increasing risk for T2DM. To characterize glucose metabolism between IA to Indians (I) living in India, we studied thirty-one Indians recruited at the Chellaram Hospital in Pune, India and twenty Indian Americans at Mayo Clinic, MN. All underwent a 3-hour 9-point OGTT with analyses of glucose, insulin and C-peptide. The oral minimal model was used to estimate β-cell function (φtotal) and insulin sensitivity (SI), with assessment of β-cell responsivity (Disposition Index: DI). Insulin clearance was calculated as AUC of insulin secretion rate over insulin concentrations. Both I and IA were similar with respect to age (33±7 vs. 39±13y), BMI (25.0±1.8 vs. 24.7± 3.2kg/m2) and sex (13F and 9F) respectively. Results are in fig 1. Fasting and iAUC glucose did not differ between groups (p=0.478), while integrated C-peptide and Insulin concentrations were higher in I than IA (p<0.001). Conversely, DI was higher in IA than I (p=0.045), due to higher insulin clearance (p=0.036) and beta-cell function [φtot] (p=0.040) in the absence of changes in insulin sensitivity. We conclude that these intriguing differences observed in Indian Americans and Indians are novel. Further studies are required to tease out the factors responsible for these differences.View largeDownload slideView largeDownload slide DisclosureV. Purandare: None. A. Galderisi: None. M. Maertino: None. A. Basu: None. C. Cobelli: None. A. Unnikrishnan: Advisory Panel; Self; Sanofi-Aventis, Other Relationship; Self; Novo Nordisk A/S, Speaker’s Bureau; Self; AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Lilly Diabetes. R. Basu: None.FundingNational Institutes of Health (R01DK029953 to R.B.), (R01DK085516 to A.B.)
Flexible electricity price forecasting by switching mother wavelets based on wavelet transform and Long Short-Term Memory (2022)

Under dynamic pricing, stable and accurate electricity price forecasting on the demand side is essential for efficient energy management. We have developed a new electricity price forecasting model that provides consistently accurate forecasts. The base prediction model decomposes the time series using wavelet transform and then predicts it by Long Short-Term Memory. Previous studies using this model have always decomposed time series in the same way without changing the mother wavelet. However, this makes it difficult to respond to changes in time series that vary daily or seasonally. Therefore, we periodically switch the mother wavelet, i.e., flexibly change the time series decomposition method, to achieve stable and highly accurate electricity price forecasting. In an experiment, the model improved prediction accuracy by up to 42.8% compared to prediction with a fixed mother wavelet. Experimental results show that the proposed flexible forecasting method can consistently provide highly accurate forecasts.
Short-term impact of a robot-assisted laparoscopic prostatectomy ‘mini-residency’ experience on postgraduate urologists' practice patterns (2006)

A 5 day intensive RALP M-R course seems to encourage postgraduate urologists, already familiar with laparoscopy, to successfully incorporate robotic surgery into their practice. The take rate, or the percentage of participants performing robotic-assisted surgery within 14 months after M-R, was 95%. Continued follow-up will ultimately determine the long-term effectiveness of this 1 week intensive training programme for postgraduate urologists.
Accurate WiFi Localization by Fusing a Group of Fingerprints via a Global Fusion Profile (2018)

The existing indoor localization approaches based on single fingerprints, such as received signal strength (RSS) and channel impulse response, are rather susceptible to the changing environment, multipath, and nonline-of-sight. It is well known that indoor localization can obtain higher positioning accuracy than the single-fingerprint-based methods by fusing multiple information sources (fingerprints/fingerprint functions). However, the existing fusion methods cannot fully exploit the intrinsic complementarity among multiple information sources and thus show lower accuracy. In this paper, we propose an accurate WiFi localization approach by Fusing A Group Of fingerprinTs (WiFi-FAGOT) via a global fusion profile (GFP). WiFi-FAGOT first constructs a WiFi-based GrOup Of Fingerprints (GOOF) in the offline phase, which consists of RSS, signal strength difference, and hyperbolic location fingerprint. Then, instead of direct localization by using the WiFi-based GOOF, we design multiple classifiers by training each fingerprint in the WiFi-based GOOF, namely GOOF classifiers. To fully leverage the intrinsic complementarity among different kinds of fingerprints, we propose a GFP construction algorithm by minimizing the average positioning error over the space of all GOOF classifiers. Finally, in the online phase, we derive a grid-dependent matching algorithm, namely, optimal classifier selection, to intelligently choose a fusion profile in the GFP for more accurate localization. Experimental results demonstrate that WiFi-FAGOT performs better than other systems in real complex indoor environments.
High efficiency Doherty amplifier combining digital adaptive power distribution and dynamic phase alignment (2013)

This paper reports a Doherty power amplifier (PA) with significantly improved efficiency over large output power range. The efficiency enhancement is accomplished by associating digital adaptive power distribution and dynamic phase alignment mechanisms, which are implemented to prevent the efficiency degradation due to the problems of input drive waste at back-off, power-dependent phase misalignment between carrier and peaking branches, and impaired load modulation behavior. The measured average efficiency of the proposed Doherty PA is 53% compared to 45% for a standard Doherty PA.
Effect of DNA sequence and structure on nuclease activity of the DexA protein of bacteriophage T4 (1988)

The bacteriophage T4 dexA gene product is required during infection of Escherichia coli strains carrying a mutation in the optA gene. We purified the DexA protein from cells which overproduced the protein. The protein was assayed for nuclease activity on synthetic di- and oligonucleotide substrates of known sequence and secondary structure. Sequence and structure significantly affected nuclease activity. The properties of the enzyme may explain the requirement for the DexA protein during infection of optA mutant hosts.
Activation of Adenosine 2A Receptors Attenuates Allograft Rejection and Alloantigen Recognition (2007)

The current studies investigated the in vitro and in vivo effect of adenosine 2A receptor (A(2A)R) agonists to attenuate allogenic immune activation. We performed MLRs with spleen T lymphocytes and APCs isolated from wild-type and A(2A)R knockout mice of both C57BL/6 and BALB/c background strains. Two-way MLR-stimulated T cell proliferation was reduced by ATL313, a selective A(2A)R agonist in a dose-responsive manner (approximately 70%; 10 nM), an effect reversed by the A(2A)R antagonist ZM241385 (100 nM). By one-way MLRs, we observed that ATL313's inhibitory effect was due to effects on both T cells and APCs. ATL313 suppressed the activation markers CD25 and CD40L and the release of inflammatory cytokines IFN-gamma, RANTES, IL-12P(70), and IL-2. ATL313 also increased negative costimulatory molecules programmed death-1 and CTLA-4 expressed on T cells. In lymphocytes activated with anti-CD3e mAb, ATL313 inhibited the phosphorylation of Zap70, an effect that was reversed by the protein kinase A inhibitor H-89. In skin transplants, allograft survival was enhanced with ATL313, an effect blocked by ZM241385. These results indicate that A(2A)R agonists attenuate allogenic recognition by action on both T lymphocytes and APCs in vitro and delayed acute rejection in vivo. We conclude that A(2A)R agonists may represent a new class of compounds for induction therapy in organ transplantation.
Optimal Multilevel ASK With Noncoherent Diversity Reception in Uncorrelated Nonidentical and Correlated Rayleigh Fading (2016)

A noncoherent quadratic diversity reception system for multilevel amplitude-shift keying (ASK) signals in Rayleigh fading with different cases of the channel covariance matrix is considered. These include the important case of distributed antennas, which exhibit uncorrelated fading with distinct mean-squared channel gains (uncorrelated nonidentical fading) and weighted energy detectors, and the cases of exponentially correlated and uniformly correlated channels with equal mean-squared channel gains. For these cases, closed-form expressions for the symbol error probability (SEP) of the system are derived using the decision statistics obtained from the maximum likelihood receiver. The problem of determining the optimal amplitude levels that minimize the SEP under a total signal energy constraint is formulated and solved analytically for the high signal-to-noise ratio (SNR) configuration and numerically for the general configuration. For the high SNR configuration, it is shown that the optimal ASK levels should follow an approximately geometric progression. It is also observed that an equally spaced ASK constellation is not optimal in terms of achieving the minimum SEP. Numerical results are presented to highlight performance trends for channel gain imbalance and correlation.
Outsourced Symmetric Private Information Retrieval. (2013)

In the setting of searchable symmetric encryption (SSE), a data owner D outsources a database (or document/file collection) to a remote server E in encrypted form such that D can later search the collection at E while hiding information about the database and queries from E. Leakage to E is to be confined to well-defined forms of data-access and query patterns while preventing disclosure of explicit data and query plaintext values. Recently, Cash et al. presented a protocol, OXT, which can run arbitrary boolean queries in the SSE setting and which is remarkably efficient even for very large databases. In this paper we investigate a richer setting in which the data owner D outsources its data to a server E but D is now interested to allow clients (third parties) to search the database such that clients learn the information D authorizes them to learn but nothing else while E still does not learn about the data or queried values as in the basic SSE setting. Furthermore, motivated by a wide range of applications, we extend this model and requirements to a setting where, similarly to private information retrieval, the client’s queried values need to be hidden also from the data owner D even though the latter still needs to authorize the query. Finally, we consider the scenario in which authorization can be enforced by the data owner D without D learning the policy, a setting that arises in court-issued search warrants. We extend the OXT protocol of Cash et al. to support arbitrary boolean queries in all of the above models while withstanding adversarial non-colluding servers (D and E) and arbitrarily malicious clients, and while preserving the remarkable performance of the protocol. 1
Long/Short Chain Mixed Cellulose Esters: Effects of Long Acyl Chain Structures on Mechanical and Thermal Properties (2016)

Long/short chain mixed cellulose esters (MCE) are practical, promising polymers with interesting properties. In the molecular design of MCE, using long acyl chains made from renewable resources is important and enhances the value of MCE as sustainable materials. In this study, we focused on two types of renewable long acyl chains for MCE: the aromatic 3-pentadecylphenoxy acetyl (PA) group derived from cardanol extracted from cashew nutshells and the aliphatic stearoyl (St) group made from vegetable oils. Using these long acyl chains and the acetyl (Ac) group as a short acyl chain, we synthesized PA/Ac MCE (P-series) and St/Ac MCE (S-series) in LiCl/DMAc medium. The thermal and mechanical analyses revealed that a mixed substitution of long and short acyl chains prevented the crystallization of the long acyl chain moieties in MCE. The P-series had slightly higher bending strength and glass transition temperature than those of the S-series but showed low impact strength because of the existence of the aromatic ring in the PA group, which caused an increase in the stiffness of the cellulose backbone and the extra intermolecular interaction. However, the S-series without aromatic rings showed remarkably improved impact strength with sufficient balanced mechanical properties for use in durable products due to its composition of low crystalline long acyl chain moieties.
Persistent Infection of a Carcinoma Thyroid Cell Line with Coxsackievirus B (2009)

We demonstrate for the first time that CVB4 could replicate in thyroid cells and could persist, with predominance of viral negative RNA strands for up to 24 days p.i. without obvious cytopathic effect. Our results suggest that CVB4 may lead to thyroid cell apoptosis. Further studies are needed to determine whether CVB could play a role in thyroid pathologies.
Supplemental Figure 6 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer (2023)

&lt;p&gt;Figure S6&lt;/p&gt;
mutA and mutC: two mutator loci in Escherichia coli that stimulate transversions. (1990)

Two transversion-specific mutator loci, mutA and mutC, were identified in Escherichia coli. Mutators with high rates of A.T----T.A transversions were identified using a screening technique that relied upon the reversion of an altered lacZ gene back to wild-type via a specific A.T----T.A transversion. Among the mutators collected, one class mapped to a previously unidentified locus that we designate mutA. Analysis of reverse mutations in lacZ and forward nonsense mutations in lacI showed that the mutA strain has higher levels of A.T----T.A and G.C----T.A transversions, and to a lesser degree A.T----C.G transversions. The mutA locus maps very near to, but is separable from, mutL, at about 95 min on the E. coli chromosome. Both its mutagenic specificity and complementation experiments confirmed that mutA is distinct from mutL and from a nearby mutator locus, miaA. The phenotype of a mutA mutL double mutator strain suggests that the mutA gene product prevents some replication errors. Another mutator, designated mutC, maps very near uvrC, at 42 min, but is distinguishable from uvrC, which has no mutator effects. The specificity of reversion of lacZ mutations in a mutC strain is identical to that in a mutA strain. Also, the behavior of a mutC mutS double mutant is identical to that of a mutA mutL double mutant. It is likely that mutA and mutC are components of the same error-avoidance system.
Nuclear receptors in early hormone refractory prostate cancer and their relationship to apoptosis-related proteins. (2002)

The expression of several genes involved in apoptosis and cell cycle control can be regulated by steroid hormones and related agents via their nuclear receptors. Members of the bcl-2 gene family participate in the regulation of apoptosis in a diverse range of cell types and are implicated in the development of hormone refractory prostate cancer and resistance to anti-cancer therapy. The aim of this study, therefore, was to examine the expression of several nuclear receptors in relation to the expression of apoptosis and cell cycle related proteins in a series of patients with early hormone refractory prostate cancer. Analysis of protein expression revealed only a weak association between Bcl-2 and AR. Bax positivity and p27Kip1 expression were significantly more frequent in the AR-positive tumors, whereas RXRbeta expression was more frequently observed in the AR-negative group. The expression of AR, Bax and p27Kip1 was inversely related, and the expression of RXRbeta directly related, to Gleason pattern status. These results suggest that the immunophenotype of early hormone refractory prostate cancer may be different to that seen in more advanced stage disease. Androgen withdrawal therapy employing anti-androgens may elicit different signalling pathways that may be dependent on ARstatus and ARsensitivity.
Doping Dependence of Thermal Oxidation on n-Type 4H-SiC (2010)

The doping dependence of dry thermal oxidation rates in n-type 4H-SiC was investigated. The oxidation was performed in the temperature range of 1000 °C to 1200 °C for samples with nitrogen doping in the range of 6.5 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">15</sup> to 9.3 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">18</sup> /cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> , showing a clear doping dependence. Samples with higher doping concentrations displayed higher oxidation rates. The results were interpreted using a modified Deal-Grove model. Linear and parabolic rate constants and activation energies were extracted. Increasing nitrogen led to an increase in the linear-rate-constant preexponential factor from 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> m/s and the parabolic-rate-constant preexponential factor from 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-9</sup> to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /s. The increase in the linear rate constant was attributed to defects from doping-induced lattice mismatch, which tend to be more reactive than bulk crystal regions. The increase in the diffusion-limited parabolic rate constant was attributed to the degradation in the oxide quality originating from the doping-induced lattice mismatch. This degradation was confirmed by the observation of a decrease in the optical density of the grown oxide films from 1.4 to 1.24. The linear activation energy varied from 1.6 to 2.8 eV, while the parabolic activation energy varied from 2.7 to 3.3 eV, increasing with doping concentration. These increased activation energies were attributed to the higher nitrogen content, leading to an increase in the effective bond energy stemming from the difference in C-Si (2.82 eV) and Si-N (4.26 eV) binding energies. This paper provides crucial information in the engineering of SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> dielectrics for SiC metal-oxide-semiconductor structures, which typically involve regions of very different doping concentrations, and suggests that thermal oxidation at high doping concentrations in SiC may be defect mediated.
Multiple Low-Dose Infusions of Human Umbilical Cord Blood Cells Improve Cognitive Impairments and Reduce Amyloid-β-Associated Neuropathology in Alzheimer Mice (2012)

Alzheimer's disease (AD) is the most common progressive age-related dementia in the elderly and the fourth major cause of disability and mortality in that population. The disease is pathologically characterized by deposition of β-amyloid plaques neurofibrillary tangles in the brain. Current strategies for the treatment of AD are symptomatic only. As such, they are less than efficacious in terms of significantly slowing or halting the underlying pathophysiological progression of the disease. Modulation by cell therapy may be new promising disease-modifying therapy. Recently, we showed reduction in amyloid-β (Aβ) levels/β-amyloid plaques and associated astrocytosis following low-dose infusions of mononuclear human umbilical cord blood cells (HUCBCs). Our current study extended our previous findings by examining cognition via (1) the rotarod test, (2) a 2-day version of the radial-arm water maze test, and (3) a subsequent observation in an open pool platform test to characterize the effects of monthly peripheral HUCBC infusion (1×10(6) cells/μL) into the transgenic PSAPP mouse model of cerebral amyloidosis (bearing mutant human APP and presenilin-1 transgenes) from 6 to 12 months of age. We show that HUCBC therapy correlates with decreased (1) cognitive impairment, (2) Aβ levels/β-amyloid plaques, (3) amyloidogenic APP processing, and (4) reactive microgliosis after a treatment of 6 or 10 months. As such, this report lays the groundwork for an HUCBC therapy as potentially novel alternative to oppose AD at the disease-modifying level.
Supplementary Table 3 from A Diverse Array of Cancer-Associated <i>MTOR</i> Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity (2023)

&lt;p&gt;XLSX file 10K, Homologous mutations from S. pombe tor2 in H. sapiens MTOR are listed&lt;/p&gt;
A Type-II Phase-Tracking Receiver (2020)

We present a new analog-to-digital converter (ADC)-based architecture of a phase-tracking receiver (PT-RX) optimized for ultra-low-power (ULP) and ultra-low-voltage (ULV) operations for the Internet of Things (IoT). The RX employs a type-II loop configuration that offers improved stability compared with the previous type-I PT-RX solutions. In addition, the type-II loop is also very tolerant of long run-lengths of consecutive “1” or “0” symbol sequences. Fabricated in 28-nm CMOS, the prototype PT-RX targets Bluetooth low energy (BLE) standard consuming only 1.5 mW at a supply of ≤0.7 V. It maintains an adjacent-channel rejection (ACR) of ≥-11/3.5/17/27 dB at 0/±1/±2/±3 MHz offset and can tolerate out-of-band (OOB) blockers of minimum -21 dBm across 1.0-3.5 GHz while also offering a best-in-class figure of merit (FoM) of 181 dB, with a 1-Mb/s BLE sensitivity of -93 dBm.
Congestive Nephropathy: A Neglected Entity? Proposal for Diagnostic Criteria and Future Perspectives (2020)

Venous congestion has emerged as an important cause of renal dysfunction in patients with cardiorenal syndrome. However, only limited progress has been made in differentiating this haemodynamic phenotype of renal dysfunction, because of a significant overlap with pre-existing renal impairment due to long-term hypertension, diabetes, and renovascular disease. We propose congestive nephropathy (CN) as this neglected clinical entity. CN is a potentially reversible subtype of renal dysfunction associated with declining renal venous outflow and progressively increasing renal interstitial pressure. Venous congestion may lead to a vicious cycle of hormonal activation, increased intra-abdominal pressure, excessive renal tubular sodium reabsorption, and volume overload, leading to further right ventricular (RV) stress. Ultimately, renal replacement therapy may be required to relieve diuretic-resistant congestion. Effective decongestion could preserve or improve renal function. Congestive acute kidney injury may not be associated with cellular damage, and complete renal function restoration may be a confirmatory diagnostic criterion. In contrast, a persistently low renal perfusion pressure might induce renal dysfunction and histopathological lesions with time. Thus, urinary markers may differ. CN is mostly seen in biventricular heart failure but may also occur secondary to pulmonary arterial hypertension and elevated intra-abdominal pressure. An increase in central venous pressure to >6 mmHg is associated with a steep decrease in glomerular filtration rate. However, the central venous pressure range that can provide an optimal balance of RV and renal function remains to be determined. We propose criteria to identify cardiorenal syndrome subgroups likely to benefit from decongestive or pulmonary hypertension-specific therapies and suggest areas for future research.