gebhart/patrepeval huggingface dataset:
Exogenous Arachidonic Acid Mediates Permeability of Human Brain Microvessel Endothelial Cells through Prostaglandin E 2 Activation of EP 3 and EP 4 Receptors (2015)

The blood‐brain barrier, formed by microvessel endothelial cells, is the restrictive barrier between the brain parenchyma and the circulating blood. Arachidonic acid (ARA; 5,8,11,14‐ cis ‐eicosatetraenoic acid) is a conditionally essential polyunsaturated fatty acid [20:4(n‐6)] and is a major constituent of brain lipids. The current study examined the transport processes for ARA in confluent monolayers of human brain microvessel endothelial cells (HBMEC). Addition of radioactive ARA to the apical compartment of HBMEC cultured on Transwell ® inserts resulted in rapid incorporation of radioactivity into the basolateral medium. Knock down of fatty acid transport proteins did not alter ARA passage into the basolateral medium due to the rapid generation of prostaglandin E 2 (PGE 2 ), an eicosanoid known to facilitate opening of the blood‐brain barrier. Permeability following ARA or PGE 2 exposure was confirmed by an increased movement of fluorescein‐labeled dextran from apical to basolateral medium. ARA‐mediated permeability was attenuated by specific cyclooxygenase‐2 inhibitors. EP 3 and EP 4 receptor antagonists attenuated the ARA mediated permeability of HBMEC. The results indicate that ARA increases permeability of HBMEC monolayers likely via increased production of PGE 2 which acts upon EP 3 and EP 4 receptors to mediate permeability. These observations may explain the rapid influx of ARA into the brain previously observed upon plasma infusion with ARA.
CCEMD: Center for Computational Engineering Molecular Dynamics. Theory and user`s guide, Version 2.2 (1995)

CCEMD (Center for Computational Engineering Molecular Dynamics) is a general purpose molecular dynamics program written in the C language, built on top of the MD program of Windemuth and Schulten. CCEMD can perform molecular dynamics, gradient minimization, genetic algorithm-based conformation searching, and ligand-protein docking. This report documents the algorithms used and provides a users` guide for the code.
Sputter Deposition of Titanium on Poly(Methyl Methacrylate) Enhances Corneal Biocompatibility (2020)

Improving the biocompatibility of the BK PMMA stem may improve long-term outcomes of implantation.
An optical and electrical hybrid system for detecting abnormal masses on mammograms using Gabor feature extractor and neural network (1999)

Abstract An optical and electrical hybrid recognition system for detecting abnormal masses on a mammogram image using a Gabor feature extractor and a neural network is presented. This prototype system detected all abnormal masses on 20 tested mammogram images without missing any.
ChemInform Abstract: AN IMPROVED PREPARATION OF N‐(TERT‐BUTYL)‐N‐(3,5‐DINITROBENZOYL)NITROXYL (1981)

Abstract tert.‐Butylamin (I) und Dibenzoylperoxid (II) werden zum Hydroxylamin‐Derivat (III) umgesetzt, das nach Acylierung mit 3,5‐Dinitrobenzoylchlorid (IV) durch Hydrazin zur Hydroxamsäure (VI) gespalten wird.
Impact of concomitant aortic stenosis on the management and outcomes of acute myocardial infarction hospitalizations in the United States (2022)

In this 18-year study, an increase in prevalence of AS in AMI hospitalization was noted. Concomitant AS was associated with lower use of guideline-directed therapies and worse clinical outcomes among AMI admissions.
First integration of Cu TSV using die-to-wafer direct bonding and planarization (2009)

Copper-filled Through-Si Vias (TSV) with diameters from 2 mum to 5 mum have been integrated in a die-to-wafer stack combining direct bonding and a planarization technique. TSVs were processed on chip backside after oxide bonding and substrate thinning. The results were compared to the ones achieved with a wafer-to-wafer test vehicle. It was demonstrated that die-to-wafer process developed for this integration does not impact TSV electrical and morphological properties. Moreover, no damage was observed on the stack during TSV process performed at 400 degC. This demonstration is the first step to validate the industrial compatibility between high density TSV process and die-to-wafer direct bonding and planarization techniques. With a resistance close to 150 mohm and a capacitance of about 30 fF, 3 mum-diameter TSV provides excellent electrical performance to heterogeneous 3D ICs.
Expression of Estrogen Sulfotransferase 1E1 and Steroid Sulfatase in Breast Cancer: A Immunohistochemical Study (2009)

It is known that the steroid sulfatase (STS) and the estrogen sulfotransferase (EST1E1) are commonly expressed in human breast carcinomas. STS and EST1E1 combined action could maintain the equilibrium between sulfated (inactive) and unconjugated (active) estrogens, which might have effects on development of hormone dependent breast cancer. We studied the expression of the STS and EST1E1 in 88 breast carcinomas and 57 adjacent non-malignant tissues by immunohistochemistry. The results were correlated with the tumor expression of estrogen receptor α (ER-α) and β (ER-β), progesterone receptor A (PR-A) and B (PR-B) and the proliferation marker CDC47, the tumoral type and stage and the age at surgery. STS expression was higher in carcinoma specimens than in adjacent normal tissues, although not to a significant level (p = 0.064) and it was positively associated with CDC47 expression (p 0.05). These observations support the hypothesis that STS is overexpressed in breast cancer and associated with a worse prognosis. EST1E1 was observed for the first time in the nuclei of epithelial and tumoral cells. Tumor expression of EST1E1 was positively correlated with ER-β (p 0.01) and PR-B (p 0.05), two steroid receptors already associated with an improve prognosis for breast cancer. Controlling the STS overexpression in carcinomas could be a way to inhibit cancer growth. The significance of the association between EST1E1 and ER-β or PR-B should be further studied since these two receptors are transcription activators and may regulate the expression of protective enzymes like EST1E1.
263: Characteristics, Predictors of Recurrence and Survival of Patients with Seminal Vesicle Invasion after Radical Prostatectomy (2005)

You have accessJournal of UrologyModerated Poster, Sunday, May 22, 2005 8:00 - 10:00 am1 Apr 2005263: Characteristics, Predictors of Recurrence and Survival of Patients with Seminal Vesicle Invasion after Radical Prostatectomy Fernando P. Secin, Fernando J. Bianco, Andrew J. Vickers, Paul A. Feam, James A. Eastham, and Peter T. Scardino Fernando P. SecinFernando P. Secin More articles by this author , Fernando J. BiancoFernando J. Bianco More articles by this author , Andrew J. VickersAndrew J. Vickers More articles by this author , Paul A. FeamPaul A. Feam More articles by this author , James A. EasthamJames A. Eastham More articles by this author , and Peter T. ScardinoPeter T. Scardino More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34528-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "263: Characteristics, Predictors of Recurrence and Survival of Patients with Seminal Vesicle Invasion after Radical Prostatectomy." The Journal of Urology, 173(4S), pp. 72–73 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 72-73 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Fernando P. Secin More articles by this author Fernando J. Bianco More articles by this author Andrew J. Vickers More articles by this author Paul A. Feam More articles by this author James A. Eastham More articles by this author Peter T. Scardino More articles by this author Expand All Advertisement PDF downloadLoading ...
Hyaluronic Acid Injections to Correct Lips Deformity Following Surgical Removal of Permanent Implant (2020)

One of the most attractive areas of the face are the lips, they are crucial for emotion and communication, both during animation and at rest. Throughout the years, several techniques to obtain permanent lip enhancement have been introduced, such as the use of nonresorbable fillers. The main problem related to permanent fillers is that undesirable results could not always be repaired; although lip sequelae can be addressed surgically, some surgeons will not perform this type of procedure due to its complexity and the lack of guidelines.In this paper, the authors present a case of a labial incompetence developed after lips implant removal performed elsewhere; after clinical examination the patient was planned for surgery, although during preoperative instrumental examination (chest X-ray) a solitary pulmonary nodule was noted; further investigation performed with needle biopsy revealed a lung cancer. For this reason, the surgical procedure planned for lip restoration was not performed; however, the patient asked for a minimally invasive procedure, thus to improve, although temporarily, her lips appearance.For the aforementioned reasons, the patient was treated just with hyaluronic acid injections achieving a pleasant result, solving also the labial incompetence at rest.To the best of the author's knowledge, this paper represents the first one describing the use of hyaluronic acid injections to restore lip competence following surgical removal of permanent implant.
Detection of label-free cancer biomarkers using nickel nanoislands and quartz crystal microbalance (2010)

We present a technique for the label-free detection and recognition of cancer biomarkers using metal nanoislands intended to be integrated in a novel type of nanobiosensor. His-tagged (scFv)-F7N1N2 is the antibody fragment which is directly immobilized, by coordinative bonds, onto ~5 nm nickel islands, then deposited on the surface of a quartz crystal of a quartz crystal microbalance (QCM) to validate the technique. Biomarker GTPase RhoA was investigated because it has been found to be overexpressed in various tumors and because we have recently isolated and characterized a new conformational scFv which selectively recognizes the active form of RhoA. We implemented a surface chemistry involving an antibiofouling coating of polyethylene glycol silane (PEG-silane) (<2 nm thick) and Ni nanoislands to reach a label-free detection of the active antigen conformation of RhoA, at various concentrations. The methodology proposed here proves the viability of the concept by using Ni nanoislands as an anchoring surface layer enabling the detection of a specific conformation of a protein, identified as a potential cancer biomarker. Hence, this novel methodology can be transferred to a nanobiosensor to detect, at lower time consumption and with high sensitivity, specific biomolecules.
O2-Binding Albumin Thin Films:  Solid Membranes of Poly(ethylene glycol)-Conjugated Human Serum Albumin Incorporating Iron Porphyrin (2007)

Poly(ethylene glycol) (PEG)-conjugated human serum albumin (HSA) incorporating the tetrakis(alpha,alpha,alpha,alpha-o-amidophenyl)porphinatoiron(II) derivative (FeP) [PEG(HSA-FeP)] is a unique plasma protein-based O2 carrier as a red blood cell substitute. The aqueous solution of PEG(HSA-FeP) [mw of PEG: 2-kDa (PEG2) or 5-kDa (PEG5)] was evaporated on a glass surface to produce a red-colored solid membrane. Scanning electron microscopy observations revealed that the PEG2(HSA-FeP) membrane consisted of two parts: (i) a surface layer made of a fibrous component (10 microm thickness), and (ii) a bottom layer of an amorphous phase (5 microm thickness). The condensed solution provided a thick membrane (70 microm), which also has the amorphous bottom layer. On the other hand, the PEG5(HSA-FeP) produced homogeneous membrane made of the fibrous component. The FeP active sites in the solid membrane formed very stable O2-adduct complexes at 37 degrees C with a half-lifetime of 40 h. The O2-binding affinity of the PEG2(HSA-FeP) membrane (P1/2 = 40 Torr, 25 degrees C) was 4-fold lower than that in aqueous solution, which is kinetically due to the low association rate constant. The membrane was soluble again in water and organic solvents (ethanol and chloroform) without deformation of the secondary structure of the protein. The addition of hyaluronic acid gave a free-standing flexible thin film, and it can also bind and release O2 as well. These O2-carrying albumin membranes with a micrometer-thickness would be of significant medical importance for a variety of clinical treatments.
ChemInform Abstract: Spider Silk: From Soluble Protein to Extraordinary Fiber (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Run-Time Enforcement of Information-Flow Properties on Android (CMU-CyLab-12-015) (2018)

Recent years have seen a dramatic increase in the number and importance in daily life of smartphones and similar mobile devices. The security properties that these devices provide to their applications, however, are inadequate to protect against many undesired behaviors. A broad class of such behaviors is violations of simple information-flow properties. This paper proposes an enforcement system that permits Android applications to be concisely annotated with information-flow policies, which the system enforces at run time. Information-flow constraints are enforced both between applications and between components within applications, aiding developers in implementing least privilege. We develop a detailed model of our enforcement system using a process calculus, and use the model to prove noninterference. Our system and model have a number of useful or novel features, including support for Android’s single- and multiple-instance components, floating labels, declassification and endorsement capabilities, and support for legacy applications. Our system design fits the Android programming model and runtime cleanly enough that we have developed a fully functional prototype on Android 4.0.4. We have tested our prototype on a Nexus S phone, verifying that it can enforce practically useful policies that can be implemented with minimal modification to off-the-shelf applications.
Bile salt and micellar fat concentration in proximal small bowel contents of ileectomy patients (1968)

Studies were carried out to test the hypothesis that abnormal bile salt metabolism (interruption of the enterohepatic circulation) is responsible for steatorrhea in patients with ileal disease and (or) ileectomy.Duodenal bile salt concentration after a single, standard meal eaten at 8 a.m. was measured in 8 patients with ileectomy steatorrhea and compared with 11 normal control subjects and 7 hospitalized patients without gastrointestinal disease. Mean bile salt concentration was approximately half normal in the ileectomy group, but some of the patients fell well within the normal range, even on repeat studies. However, it was shown that the second and third meals eaten during a single day were associated with a marked depression of duodenal bile salt concentration in ileectomy patients, which suggested that the first meals in these patients flush out a large fraction of the bile salt pool. Simultaneously measured turnover studies with taurocholate-(14)C showed at t((1/2)) of 3.1 hr in these patients compared with 29.5 and 32 hr in two control subjects, proving that the enterohepatic circulation had indeed been interrupted by ileectomy. Hepatic synthesis can apparently partially reconstitute the bile salt pool during the overnight period. Additional studies were carried out to determine the relation between bile salt and micellar fat concentration in proximal small bowel contents after ingestion of the same standard meal. Below a bile salt concentration of 1.7 mg/ml, less than 0.8 mg/ml of lipid existed in the micellar phase of intestinal contents, whereas when bile salt concentration exceeded this level the amount of fat in the micellar phase rose progressively. Only 1 of 11 samples from three ileectomy patients had a micellar fat concentration > 0.8 mg/ml, whereas 33 of 42 samples from control subjects had micellar fat concentration > 0.8 mg/ml.Thus, abnormally low duodenal bile salt concentration during at least a portion of the day, with the associated depression of micellar fat, appears to be a major cause of decreased fat absorption in patients with ileectomy steatorrhea.
Síntese, caracterização e propriedades espectroscópicas de criptatos de lantanídeo do tipo [Ln<FONT FACE=Symbol>Ì</FONT>(bipy)2py(CO2Et) 2(3+)] (2004)

SPECTROSCOPIC PROPERTIES OF [Ln⊂(bipy) 2 py(CO 2 Et) 2 ] 3+ LANTHANIDE CRYPTATES.This work reports on the synthesis, characterization (infrared and hidrogen nmr spectra) and photophysical properties (luminescence spectra and emission quantum yield) of the lanthanide cryptates [Ln⊂(bipy) 2 py(CO 2 Et) 2 ] 3+ with Ln = Eu 3+ , Tb 3+ or Gd 3+ , which can be applied as efficient Light-Conversion-Molecular-Devices.From emission spectra of [Eu⊂(bipy) 2 py(CO 2 Et) 2 ] 3+ it was possible to assign C 3 symmetry to the metal ion.The spectroscopic studies show a higher emission quantum yield (q=25%) for [Tb⊂(bipy) 2 py(CO 2 Et) 2 ] 3+ in aqueous solution, whereas the europium cryptate presents q=14%.This is justified by a more efficient energy transfer between triplet and emission levels of terbium (T→ 5 D 4 ).
The clinical characteristics of X-linked acro-gigantism syndrome (2015)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Tungsten(0) inserts into a carbon–fluorine bond in the presence of a carbon–hydrogen bond (1991)

The first examples of chelate assisted insertion of a transition metal centre into a C–F bond of mono- and di-fluoro substituted aromatic rings resulting in chelate stabilized aryl fluoride oxidative addition complexes are reported.
A mAb against surface-expressed FSHR engineered to engage adaptive immunity for ovarian cancer immunotherapy (2022)

Despite advances in ovarian cancer (OC) therapy, recurrent OC remains a poor-prognosis disease. Because of the close interaction between OC cells and the tumor microenvironment (TME), it is important to develop strategies that target tumor cells and engage components of the TME. A major obstacle in the development of OC therapies is the identification of targets with expression limited to tumor surface to avoid off-target interactions. The follicle-stimulating hormone receptor (FSHR) has selective expression on ovarian granulosa cells and is expressed on 50%-70% of serous OCs. We generated mAbs targeting the external domain of FSHR using in vivo-expressed FSHR vector. By high-throughput flow analysis, we identified multiple clones and downselected D2AP11, a potent FSHR surface-targeted mAb. D2AP11 identifies important OC cell lines derived from tumors with different mutations, including BRCA1/2, and lines resistant to a wide range of therapies. We used D2AP11 to develop a bispecific T cell engager. In vitro addition of PBMCs and T cells to D2AP11-TCE induced specific and potent killing of different genetic and immune escape OC lines, with EC50s in the ng/ml range, and attenuated tumor burden in OC-challenged mouse models. These studies demonstrate the potential utility of biologics targeting FSHR for OC and perhaps other FSHR-positive cancers.
Naturally Occurring Antihormones (1988)

Department of Reproductive Medicine M-025, University of California, San Diego, La Jolla, California Science 239: 72, 1988
Synthesis and Structure−Activity Relationships of 1-Aralkyl-4-Benzylpiperidine and 1-Aralkyl-4-Benzylpiperazine Derivatives as Potent σ Ligands (2004)

In the attempt to define more accurately structure-affinity relationships for sigma(1) and sigma(2) ligands, we synthesized and tested on sigma subtype receptors a series of aralkyl derivatives of 4-benzylpiperidine, in which the effect of modifications on the aralkyl moiety was studied in a systematic way. The affinity of the compounds here described varied to a great extent, with a sigma(2)/sigma(1) selectivity ranging from 0.1 to 9. Thus, to confirm the ability of the piperazine derivative to bind to sigma(1) receptors in a different way than piperidines, we synthesized and tested a series of piperazine compounds; the comparison of their affinity with that of the corresponding piperidines strongly supports the possibility of a different binding mode. While the compounds here described are on the whole selective for sigma vs serotonin 5-HT(1A) and dopamine D(2) receptors, 9aa, 9ba and 9ab possess a remarkable affinity for both sigma and 5-HT(1A) receptors, with K(i) in the nanomolar range, and are selective with respect to D(2) receptors. They displayed also a partial agonist profile in a human 5-HT(1A) [(35)S]GTP gamma S binding assay, suggesting their potential use as atypical antipsychotic agents.
Wideband mechanical energy harvester based on piezoelectric longitudinal mode (2012)

This paper presents how an adjustable electrical load can be used to achieve a wideband mechanical vibration energy harvester based on piezoelectric material. We discuss within this paper the design optimization of the developed structure in terms of coupling mode and cantilever shape. The developed device is based on longitudinal piezoelectric mode; it features two principal modes, 208 Hz at short circuit condition and 294 Hz at open condition. The adjustable electrical load coupled with the piezoelectric material will allow a controllable shift of the resonant frequency between these two principal modes.
High-frame-rate deep-ultraviolet-optimized charge-coupled device for simultaneous measurements of illumination intensity, polarization amplitude, and polarization direction for very high numerical aperture imaging systems (2005)

Lincoln Laboratory has designed and fabricated a charge-coupled device (CCD) array capable of imaging both polarization and illumination uniformity. The device consists of an 1107-element linear array of UV-optimized silicon photodiodes readout by a three-stage CCD through a single ~1-MHz output amplifier. This yields an effective clock rate for the whole array of ~1 kHz. Each of the active diode surfaces within the 1107-element array is covered by a UV-opaque layer of polysilicon into which are patterned 140-nm, transmissive sampling slits. The orientation and location of the slits enables simultaneous determination of illumination uniformity, degree and direction of polarization, and polarization uniformity. The device is tested with a 193-nm excimer laser equipped with variably polarized illumination and the theoretical performance of the device was supported by finite-difference time domain optical simulations.
Ab initiotheory of the Si(111)-(7×7) surface reconstruction: A challenge for massively parallel computation (1992)

An ab initio investigation of the Si(111)-(7\ifmmode\times\else\texttimes\fi{}7) surface reconstruction is undertaken using the state of the art in massively parallel computation. Calculations of the total energy of an \ensuremath{\sim}700 effective-atom supercell are performed to determine (1) the fully relaxed atomic geometry, (2) the scanning-tunneling-microscope images as a function of bias voltage, and (3) the energy difference between the (7\ifmmode\times\else\texttimes\fi{}7) and the (2\ifmmode\times\else\texttimes\fi{}1) reconstructions. The (7\ifmmode\times\else\texttimes\fi{}7) reconstruction is found to be energetically favorable to the (2\ifmmode\times\else\texttimes\fi{}1) surface by 60 meV per (1\ifmmode\times\else\texttimes\fi{}1) unit cell.