gebhart/patrepeval huggingface dataset:
PHASE I CLINICAL TRIAL OF VACCINATION OF MPHOSPH1 AND DEPDC1 EPITOPE PEPTIDE VACCINE FOR PATIENTS WITH BLADDER CANCER (2009)

You have accessJournal of Urology1 Apr 2009PHASE I CLINICAL TRIAL OF VACCINATION OF MPHOSPH1 AND DEPDC1 EPITOPE PEPTIDE VACCINE FOR PATIENTS WITH BLADDER CANCER Wataru Obara, Mitsugu Kanehira, Ryo Takata, Takuya Tsunoda, Koji Yoshida, Toyomasa Katagiri, Yusuke Nakamura, and Tomoaki Fujioka Wataru ObaraWataru Obara More articles by this author , Mitsugu KanehiraMitsugu Kanehira More articles by this author , Ryo TakataRyo Takata More articles by this author , Takuya TsunodaTakuya Tsunoda More articles by this author , Koji YoshidaKoji Yoshida More articles by this author , Toyomasa KatagiriToyomasa Katagiri More articles by this author , Yusuke NakamuraYusuke Nakamura More articles by this author , and Tomoaki FujiokaTomoaki Fujioka More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60994-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "PHASE I CLINICAL TRIAL OF VACCINATION OF MPHOSPH1 AND DEPDC1 EPITOPE PEPTIDE VACCINE FOR PATIENTS WITH BLADDER CANCER." The Journal of Urology, 181(4S), p. 349 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 349 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetrics Author Information Wataru Obara More articles by this author Mitsugu Kanehira More articles by this author Ryo Takata More articles by this author Takuya Tsunoda More articles by this author Koji Yoshida More articles by this author Toyomasa Katagiri More articles by this author Yusuke Nakamura More articles by this author Tomoaki Fujioka More articles by this author Expand All Advertisement PDF downloadLoading ...
Herbimycin A Suppresses the Reduction of Gap‐junctional Intercellular Communication Induced by Tumor‐promoting Phorbol Ester in 3T3‐L1 Cells (1989)

We have examined the suppressive effect of herbimycin A on the reduction of gap-junctional intercellular communication that is induced by a tumor-promoting phorbol ester in 3T3-L1 cells. Most cells in growth arrest participated in dye-coupling, as evaluated by the transfer between cells of a fluorescent dye (Lucifer Yellow CH). Treatment of cells with 0.25 microgram/ml herbimycin A slightly enhanced the dye-coupling. This enhancement required treatment for periods as long as 24 h. Addition of 100 ng/ml 12-O-tetradecanoylphorbol-13-acetate (TPA) caused a rapid reduction of dye-coupling. However, addition of TPA did not suppress dye-coupling in cells pretreated for more than 24 h with herbimycin A. Pretreatment of cells for less than 6 h with herbimycin A did not suppress the TPA-induced reduction of dye-coupling. These results suggest that herbimycin A suppresses the reduction of gap-junctional intercellular communication that is induced by TPA through enhancement of the ability of the cells to participate in gap-junctional intercellular communication.
Biomolecular electronic devices with Photosystem I reaction centers (2003)

This paper will present our measurements of the electrical and optical properties of isolated Photosystem I (PSI) molecules and then show the results of our attempts to produce "bulk devices" which incorporate a large number of PSI molecules into an optically-sensitive test structure. Finally, we will present our strategies for incorporating the PSI molecules into self-assembled circuits that implement useful logical functions.
A reliable soft-output of autoregressive ML detector for perpendicular magnetic recording with intertrack interference (2008)

In this paper, we consider a behavior of an autoregressive maximum-likelihood (ARML) detector and that of a conventional partial-response ML (PRML) detector against intertrack interference (ITI) of a perpendicular magnetic recording. Based on the consideration, we propose a calculation of a branch metric with the ITI estimation for the ARML detector, And also, we explain that the performance of the ARML detector is sensitive to the ITI. Finally, we show that our proposed ARML detector can derive a better performance against the ITI.
A Novel Biasing Technique for Addressable Parametric Arrays (2009)

Addressable arrays that use switches to isolate the devices being tested are limited in size and utility by the parasitic leakage caused by those switches. A new biasing technique that reduces the leakage of these switches has been studied to address this problem. Simulations performed in a 90 nm low-power technology predicted almost a two-decade drop in parasitic leakage of the array. Experimental data confirmed this improvement. 1 times 32 and 4 times 32 arrays using this biasing technique were used to investigate probe pad effects, device variability and geometry dependence.
Two-dimensional photonic bandgap defect laser (1999)

We have demonstrated optically pumped two-dimensional photonic crystal defect InGaAsP MQW lasers at 1.5 μm. Pulsed lasing action at 143 K has been obtained in microcavities as small as 2(λ/2n)^3.
Abstract 13432: Association Between a Deep Learning Enabled Algorithm Using ECG Signals to Predict Coronary Calcium and Survival (2022)

Background: We developed a deep learning algorithm to predict elevated coronary artery calcium (CAC) score from 12-lead electrocardiograms (CAC- ECG). We tested the hypothesis that this CAC-ECG algorithm will independently predict long-term survival. Methods: We leveraged a historical cohort of 43,210 consecutive patients who from the years 1997-2020 underwent clinically indicated ECG-gated unenhanced chest computed tomography (CT) to identify and quantify CAC and had an ECG within 1 year of the CT. Data on cardiovascular risk (CV) factors, and to calculate the Pooled Cohort Equation (PCE) for ASCVD was collected as part of preventive cardiology or general medical evaluations. We used the oldest CAC in record and excluded those taking statins at the time of the CAC. The algorithm was trained in 60% of the cohort, and the association between CAC-ECG and survival was evaluated with multivariate cox proportional hazard models in 40% of the remaining observations. Results: Of the 17,284 evaluated patients, mean ± SD age 55.9 ± 9.9, 33% female, 3,714 (21%) had elevated CAC ≥ 300. During an average of 15±5.9 years follow-up, 848 (5%) patients died. The algorithm’s area under the receiving operating characteristics curve (ROC), sensitivity, specificity, and accuracy to detect a CAC ≥ 300 were 0.83, 0.90%, 0.56%, 0.60%. Those with elevated CAC had a nearly two-fold risk of death, a value similar to those deemed positive by the ECG-CAC algorithm ( Figure A ). Risk of death increased with CAC-ECG probability quartiles ( Figure A ). The CAC-ECG algorithm enhanced predicted capabilities of the PCE across all ASCVD risk subgroups ( Figure B ), as well as in those with no CAC and elevated CAC ( Figure C ), all p for trend &lt;0.001. Conclusions: A deep learning-enabled CAC-ECG algorithm was independently associated with long-term survival and enhanced current risk prediction paradigms. The CAC-ECG algorithm could help identify individuals at risk in primary prevention of CV disease.
Stability of crystalline Gd2O3thin films on silicon during rapid thermal annealing (2008)

We investigate the impact of rapid thermal anneals on structural and electrical properties of crystalline Gd2O3 layers grown on Si with different orientations. Due to additional oxygen from the annealing ambient, a structureless two-layer stack (silicon-oxide-like and silicate-like) between the silicon and the crystalline oxide will be formed. The degradation of layers can be significantly reduced by sealing the layer with a-Si prior to annealing. For the capped layers, the effective capacitance equivalent thickness increases only slightly even after a 1000 °C anneal.
Accent Classification in Speech (2006)

Apart form the word content and identity of a speaker; speech also conveys information about several soft biometric traits such as accent and gender. Accurate classification of these features can have a direct impact on present speech systems. An accent specific dictionary or word models can be used to improve accuracy of speech recognition systems. Gender and accent information can also be used to improve the performance of speaker recognition systems. In this paper, we distinguish between standard American English and Indian Accented English using the second and third formant frequencies of specific accent markers. A GMM classification is used on the feature set for each accent group. The results show that using just the formant frequencies of these accent markers is sufficient to achieve a suitable classification for these two accent groups.
Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre (1996)

We have examined the effects of 11 substitutions of active centre gorge residues of human acetylcholinesterase (HuAChE) on the rates of phosphonylation by 1,2,2-trimethylpropyl methyl-phosphonofluoridate (soman) and the aging of the resulting conjugates. The rates of phosphonylation were reduced to as little as one-seventieth, mainly in mutants of the hydrogen-bond network (Glu-202, Glu-450, Tyr-133). These recombinant enzymes as well as the F338A, W86A, W86F and D74N mutant HuAChEs varied in their resistance to aging (15-3300-fold relative to the wild type). The most dramatic resistance to aging was observed for the phosphonyl conjugate of the mutant W86A enzyme (1850-3300-fold relative to the wild type). It is proposed that Trp-86 contributes to the aging process by stabilizing the evolving carbonium ion on the 1,2,2-trimethylpropyl moiety, via charge-pi interaction. The rate-enhancing effect of Trp-86 provides a rationale for the unique facility of aging in soman-inhibited cholinesterases, compared with the corresponding conjugates in other serine hydrolases. Replacements of Glu-202 by aspartic acid, glutamine or alanine residues resulted in a similar (1/130-1/300) decrease of the rates of aging. A comparable decrease was also observed for the conjugate of the F338A mutant. These results, and the similar pH dependence of aging rates for the wild-type and E202Q and F338A mutant HuAChEs, indicate that Glu-202 is not involved in proton transfer to the phosphonyl moiety. On the basis of these findings and of molecular modelling we suggest that Glu-202 and Phe-338 contribute to the aging process by stabilizing the imidazolium of the catalytic triad His-447 via charge-charge and charge-pi interactions respectively, thereby facilitating an oxonium formation on the phosphonyl moiety.
Demonstration of a novel low cost single material temporary bond solution for high topography substrates based on a mechanical wafer debonding and innovative adhesive removal (2015)

Among the technological developments pushed by the emergence of 3D-ICs, wafer thinning has become a key element in device processing over the past years. As technology matures, more emphasis is now being put on the overall cost of ownership, which is still regarded as a refraining element for technology adoption. Therefore novel temporary bond concepts and materials are being explored to further bring down the process complexity and cost.
Fatigue crack propagation behavior of cellulose esters (1994)

Abstract The effect of plasticizer concentration on fatigue crack propagation (FCP) rate in cellulose acetate‐propionate (CAP) was determined. Compact tension specimens were machined from 6.2 mm‐thick injection molded plaques and tested on an MTS servohydraulic testing machine using a sinusoidal waveform with a frequency of 1 Hz. Two FCP mechanisms were identified: a crazing mechanism, which dominated at low values of stress intensity factor range, Δ K , and a shear yielding mechanism, which dominated at high values of Δ K . The value of Δ K at the onset of the transition from the crazing mechanism to the shear yielding mechanism was a function of plasticizer concentration, and therefore yield strength of the CAP. The transition in crack propagation mechanism created a V‐shaped feature on the fracture surface, which could be used to weight the contributions from the two crack propagation mechanisms to the overall FCP rate.
Restoring autonomic balance: future therapeutic targets (2013)

Our aim was to highlight the very recent and rapid expansion of a number of contemporary, pioneering and projected interventional approaches for resistant hypertension. Our discussions of each approach centre on a new model of the cardiovascular system that emphasises the importance of the sympathetic nervous system, its differential control and reflex activation. Four interventional therapeutic strategies are discussed including targeted sympathectomies and carotid body ablation. Harnessing endogenous homeostatic control systems looks promising as a means to correct autonomic balance. The challenge will be in deciding which interventional approach should be selected.
Safety and preliminary immunogenicity of JNJ-64041809, a live attenuated, double-deleted Listeria monocytogenes-based immunotherapy, in metastatic castration-resistant prostate cancer (mCRPC). (2019)

e16509 Background: The safety and immunogenicity of JNJ-64041809 (JNJ-809), a live attenuated, double-deleted Listeria monocytogenes (LADD- Lm)-based immunotherapy targeting relevant prostate cancer antigens, was evaluated in a phase 1, multicenter, open-label study in patients (pts) with mCRPC. Methods: Men aged ≥18 years with progressive mCRPC who had received ≥2 prior approved therapies were included. The recommended phase 2 dose (RP2D) and the safety and immunogenicity of JNJ-809 were evaluated. Dose-limiting toxicities (DLTs), adverse events (AEs), T cell response, tumor response, and JNJ-809 bacterial shedding profile were assessed at 2 dose levels, 1 x 10 8 and 1 x 10 9 colony forming units (CFU). Results: 26 pts (median age 66.5 years, White 96%) were enrolled (1 x 10 8 CFU, n = 6; 1 x 10 9 CFU, n = 20). Median duration of treatment was 2.5 months (range 0-9.7). No DLTs occurred and 1 x 10 9 CFU was selected as the RP2D. Most common AEs were chills (n = 24, 92%), pyrexia (n = 21, 81%), and fatigue (n = 16, 62%). Grade ≥3 AEs were reported in 18 (69%) pts and serious AEs in 7 (27%) pts including 1 pt with investigator-assessed treatment-related grade 3 intestinal obstruction. At 1 x 10 8 CFU, all pts had negative blood cultures. At 1 x 10 9 CFU, 6 pts had LADD- Lm-positive blood cultures on day 1; blood cultures on all subsequent days were negative. JNJ-809 transiently induced peripheral cytokines including interferon-γ, interleukin-10, and tumor necrosis factor-α. Of 7 evaluable pts (1 x 10 9 CFU), post-treatment T cell responses were demonstrated in 6 pts to the Listeria antigen LLO and in 5 pts to ≥1 of the 4 encoded tumor antigens. Best overall response was stable disease (SD) in 13/25 evaluable pts with SD ≥16 weeks in 4 pts. The study was terminated early as the data collected from 26 pts were considered sufficient to evaluate safety and immune responses. Conclusions: JNJ-809 has a manageable safety profile consistent with that of other LADD- Lm-based therapies. Observed activation of immune responses with monotherapy did not translate into clinical activity, and further development of JNJ-809 will likely require a combination approach. Clinical trial information: NCT02625857.
Real-time blur with chromatic aberration drives accommodation and depth perception (2019)

In computer-generated imagery and vision science, defocus blur is often rendered to simulate objects closer or farther than the focal plane. But depth-dependent optical effects, like longitudinal chromatic aberration (LCA), are not implemented in a physically correct manner. Recent evidence has shown that incorporating LCA into rendered images produces a powerful cue for driving accommodation and depth perception. But implementing correct LCA effects is computationally expensive. Applied implementations of defocus blur with LCA are possible, but require approximations in order to run in real-time. We investigated whether real-time implementation of blur with LCA using approximate blur kernels and simplified treatment of occlusions can still drive accommodation and improve perceived depth compared to conventional methods that do not incorporate LCA. We measured accommodative responses with an autorefractor while participants viewed stimuli at various real and simulated distances. For real changes, a focus-tunable lens altered the optical distance of the stimulus, producing a blurred retinal image with the observer’s natural aberrations. For simulated changes, optical distance was constant and rendered image content changed. These stimuli were generated using 1) conventional defocus blur with all color channels treated the same; 2) defocus blur and LCA with each channel treated correctly; or 3) approximate defocus and LCA using truncated 2D Gaussian blur kernels within a real-time game engine. Simulated changes in defocus with LCA (both physically accurate and real-time) drove accommodation as well as real changes. In another experiment, participants viewed images with two planes, one partially occluding the other, and made relative depth judgments. Incorporating physically correct rendered LCA or real-time approximations improved depth ordering relative to conventional techniques that do not incorporate LCA. Chromatic information is important for accommodation and depth perception and can be implemented in real-time applications.
Micromanipulation Using Distributed Electromagnetic Actuators (1996)

Abstract A method of micromanipulation using a microcoil array is proposed. Active coils drive permanent magnets on a work platform. The magnets can push mechanical parts to perform 2-dimensional assembly. Three-dimensional operation may be achieved from 2D magnet motion when the permanent magnets are parts of a closed loop spatial linkage. Manipulation on a 4 cm × 4 cm coil array was tested, and based on this large scale experiment, we fabricated a microcoil array using IC-based processes. A 4 × 4 microcoil array with 8 turns per coil was fabricated. The chip area, including bonding pads, is 3.6 mm × 3.6 mm. The minimum current necessary to attract a magnet and its speed were measured. A 0.6 mm × 0.6 mm × 0.3 mm magnet was found to move at 79 mm/s. The top speed for a magnet to follow a square trajectory was also measured. It was demonstrated that a 1.1 mg magnet could push a 13.4 mg object out of the microcoil array.
Causes of Delivery and Outcomes of Very Preterm Twins Stratified to Zygosity (2012)

The increasing rates of preterm birth among twins implicate that solid data on associated risks and outcomes are required. Assessment of zygosity is often based on clinical criteria (evaluation of placenta; same gender, birth weight discordance as surrogate criteria for monochorionic/monozygotic twins). The aim of this study was to compare clinical versus genetic assessment of zygosity and to compare causes of preterm delivery as well as outcome data of very-low-birth-weight (VLBW; birth weight <1,500 g) twins stratified to zygosity. In a multicenter study, we selected n=176 sets of same gender twins and determined zygosity genetically. In a subgroup of 123 sets of twins, the attending physicians at the study centers were asked to document the parameter 'zygosity' (monozygotic/dizygotic) on the basis of their clinical judgment. Concordance between genetic and clinical assessment was 62.7% for monozygotic twins and 88.9% for dizygotic twins, respectively. Outcome parameters (death, BPD, ROP, NEC, IVH) were comparable in both groups. Genetically dizygotic twins were significantly more often born due to intrauterine infection (33% vs. 20% in monozygotic twins, p<.01) and antenatal antibiotics were more frequently given to mothers of dizygotic twins (62% vs. 47% in monozygotic twins, p<.01). Obstetric complications such as twin-twin-transfusion-syndrome were only seen in monozygotic twins as expected. The unexpected increase of antenatal antibiotic treatment and birth due to intrauterine infection in dizygotic twins should be confirmed in additional VLBW twin-cohorts.
Modeling the Spray Atomization of Emulsion Embedded Agricultural Solutions (2010)

Abstract A typical agricultural chemical spray process involves atomizing a liquid stream of diluted pesticide solution through hydraulic spray nozzles that inherently produce a wide spectrum of spray droplet sizes. Finer droplets have higher potential for off-target movement or drift, which is of concern due to its potential impact on neighboring crops and livestock, sensitive ecological resources, and human health. Research by the Spray Drift Task Force and others has demonstrated that, although spray nozzle selection and application parameters are the key factors to produce the desired droplet size spectrum, the physical properties of the spray solution have significant effects on the droplet size distribution for various kinds of nozzles. One of these properties of many spray fluids is the inclusion of an oil phase in the form of an emulsion. The effect of oil-in-water emulsions on the spray droplet size distribution has been demonstrated by previous work. However, the mechanisms of this effect are largely unknown. In this study, a method to model this effect was proposed. A characteristic dimensionless number for connecting the bulk spray properties and the microscopic emulsion droplet properties was defined as the ratio between the emulsion recovery time and the spray atomization time. This study will help in the design of agricultural spray nozzles and the optimization of anti-drift spray additives.
Heavy ion fusion gas desorption issues (2003)

Author(s): Molvik, A.W.; Bieniosek, F.M.; Barnard, J.J.; Bringa, E.M.; Calahan, D.A.; Celata, C.M.; Cohen, R.H.; Friedman, A.; Furman, M.A.; Kwan, J.W.; Logan, B.G.; Meier, W.R.; Sakumi, A.; Seidl, P.A.; Stoeffl, W.; Yu, S.S.
Comparison of the 5.8S rRNA Gene and Internal Transcribed Spacer Regions of Trichomonadid Protozoa Recovered from the Bovine Preputial Cavity (2003)

Sequence analysis of the 5.8S rRNA gene and the internal transcribed spacer regions (ITSRs) was used to compare trichomonadid protozoa (n = 39) of varying morphologies isolated from the bovine preputial cavity. A multiple sequence alignment was performed with bovine isolate sequences and other trichomonadid protozoa sequences available in GenBank. As a group, Tritrichomonasfoetus isolates (n = 7) had nearly complete homology. A similarity matrix showed low homology between the T. foetus isolates and other trichomonads recovered from cattle (<70%). Two clusters of trichomonads other than T. foetus were identified. Eighteen isolates comprised 1 group. These isolates shared >99% homology among themselves and with Pentatrichomonas hominis. The other non-T. foetus cluster (n = 14) did not exhibit a high degree of homology (<87%) with other bovine isolates or any of the trichomonad sequences available in GenBank. The sequence homology among isolates in that cluster was >99%, except for 1 isolate that varied from the others in both ITSRs (approximately 2% dissimilarity). Sequence analysis of the 5.8S rRNA gene and ITSRs was useful for comparing trichomonadid protozoa isolated from the bovine preputial cavity and demonstrated that 2 distinct types of trichomonads constituted the non-T. foetus isolates recovered from the bovine preputial cavity.
The Drug Evaluation Classification Program: using ocular and other signs to detect drug intoxication. (1998)

Ocular and other physiological signs can be used to detect drug intoxication and classify the type of drug taken. Knowledge of the procedures used in the Drug Recognition Program can enable optometrists to serve as consultants to the police and as expert witnesses in cases involving the use of ocular signs that indicate illicit drug use.