gebhart/patrepeval huggingface dataset:
Action Governor for Discrete-Time Linear Systems with Non-Convex Constraints (2020)

This paper introduces an add-on, supervisory scheme, referred to as Action Governor (AG), for discrete-time linear systems to enforce exclusion-zone avoidance requirements. It does so by monitoring, and minimally modifying when necessary, the nominal control signal to a constraint-admissible one. The AG operates based on set-theoretic techniques and online optimization. This paper establishes its theoretical foundation, discusses its computational realization, and uses two simulation examples to illustrate its effectiveness.
Transcription Factor Homeobox D9 Drives the Malignant Phenotype of HPV18-Positive Cervical Cancer Cells via Binding to the Viral Early Promoter (2021)

Persistent infections with two types of human papillomaviruses (HPV), HPV16 and HPV18, are the most common cause of cervical cancer (CC). Two viral early genes, <i>E6</i> and <i>E7</i>, are associated with tumor development, and expressions of <i>E6</i> and <i>E7</i> are primarily regulated by a single viral promoter: <i>P97</i> in HPV16 and <i>P105</i> in HPV18. We previously demonstrated that the homeobox D9 (HOXD9) transcription factor is responsible for the malignancy of HPV16-positive CC cell lines via binding to the <i>P97</i> promoter. Here, we investigated whether HOXD9 is also involved in the regulation of the <i>P105</i> promoter using two HPV18-positive CC cell lines, SKG-I and HeLa. Following the HOXD9 knockdown, cell viability was significantly reduced, and <i>E6</i> expression was suppressed and was accompanied by increased protein levels of P53, while mRNA levels of <i>TP53</i> did not change. <i>E7</i> expression was also downregulated and, while mRNA levels of <i>RB1</i> and <i>E2F</i> were unchanged, mRNA levels of E2F-target genes, <i>MCM2</i> and <i>PCNA</i>, were decreased, which indicates that the HOXD9 knockdown downregulates <i>E7</i> expression, thus leading to an inactivation of E2F and the cell-cycle arrest. Chromatin immunoprecipitation and promoter reporter assays confirmed that HOXD9 is directly associated with the <i>P105</i> promoter. Collectively, our results reveal that HOXD9 drives the HPV18 early promoter activity to promote proliferation and immortalization of the CC cells.
Fluorescent-Labeled Bioconjugates of the Opioid Peptides Biphalin and Dpdpe Incorporating Fluorescein–Maleimide Linkers (2017)

Our data suggest that the biphalin scaffold could be employed to develop fluorescent ligands with the appropriate fluorescent motif, and suggest a means for further probe development.
Quantum Information on Nonlinearly Coupled Optical Modes (2020)

Pursuing room-temperature quantum hardware, we discuss multi-mode optical cavities with nonlinear couplings and focus on material and fabrication requirements for such devices. We demonstrate their use for a number of quantum communication and computation tasks.
Cycloid scanning for wide field optical coherencetomography endomicroscopy and angiography in vivo (2017)

Devices that perform wide field of view optical scanning are important for the endoscopic in situ assessment and diagnosis of luminal organ disease such as in the gastrointestinal tract. Optical scanning for imaging of organ lumens in vivo has traditionally relied on one or more mechanical actuations at the proximal end of the catheter device, limiting scan accuracy and imaging speed. There is an unmet need for rapid and precise 2-dimensional (2-D) micro-scanning technologies that could enable the translation of benchtop scanning microscopies to in vivo endoscopic imaging. We demonstrate high speed, side-viewing endomicroscopy in vivo, using a new cycloid scanning optical coherence tomography (OCT) tethered capsule. The cycloid capsule incorporates a piezoelectrically actuated resonant fiber scanner to perform a precision, small field of view, fast scan and a micromotor scanner to generate a wide field of view, slow scan, which together distally scan the beam in a 2-D cycloid pattern, generating an unwrapped ~38 mm2 strip field-of-view (FOV). Using ultrahigh speed swept-source OCT at 1.17 MHz axial scan rate, imaging of the human rectum was performed at 3 volumes/sec. Multiple continuously acquired volumes were mosaicked to generate a larger FOV. We further demonstrate OCT angiography at 0.5 volumes/sec, producing volumetric images of vasculature without contrast agents. Cycloid micro-scanning technology promises to enable 2-D beam scanning for endoscopic side viewing using not only OCT but other scanning modalities
Classics in Chemical Neuroscience: Memantine (2017)

Memantine was the first breakthrough medication for the treatment of moderate to severe Alzheimer's disease (AD) patients and represents a fundamentally new mechanism of action (moderate-affinity, uncompetitive, voltage-dependent, N-methyl-d-aspartate (NMDA) receptor antagonist that exhibits fast on/off kinetics) to modulate glutamatergic dysfunction. Since its approval by the FDA in 2003, memantine, alone and in combination with donepezil, has improved patient outcomes in terms of cognition, behavioral disturbances, daily functioning, and delaying time to institutionalization. In this review, we will highlight the historical significance of memantine to AD (and other neuropsychiatric disorders) as well as provide an overview of the synthesis, pharmacology, and drug metabolism of this unique NMDA uncompetitive antagonist that clearly secures its place among the Classics in Chemical Neuroscience.
Isolation and structures of two novel anti-mite substances, AB3217-B and C. (1992)

We previously reported1} the isolation and structure determination of a novel anti-mite substance, AB3217-A (1), one of the components of an anti-mite substance complex produced by
Measurement of the tt ¯ production cross section in the dilepton channel in pp collisions at root s=8 TeV (2014)

Journal of High Energy Physics 2012.2 (2014): 024 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)
Motor Mechanism for Protein Threading through Hsp104 (2009)

The protein-remodeling machine Hsp104 dissolves amorphous aggregates as well as ordered amyloid assemblies such as yeast prions. Force generation originates from a tandem AAA+ (ATPases associated with various cellular activities) cassette, but the mechanism and allostery of this action remain to be established. Our cryoelectron microscopy maps of Hsp104 hexamers reveal substantial domain movements upon ATP binding and hydrolysis in the first nucleotide-binding domain (NBD1). Fitting atomic models of Hsp104 domains to the EM density maps plus supporting biochemical measurements show how the domain movements displace sites bearing the substrate-binding tyrosine loops. This provides the structural basis for N- to C-terminal substrate threading through the central cavity, enabling a clockwise handover of substrate in the NBD1 ring and coordinated substrate binding between NBD1 and NBD2. Asymmetric reconstructions of Hsp104 in the presence of ATPγS or ATP support sequential rather than concerted ATP hydrolysis in the NBD1 ring.
Coherent Population Trapping of Single Spins in Diamond under Optical Excitation (2006)

Coherent population trapping is demonstrated in single nitrogen-vacancy centers in diamond under optical excitation. For sufficient excitation power, the fluorescence intensity drops almost to the background level when the laser modulation frequency matches the 2.88 GHz splitting of the ground states. The results are well described theoretically by a four-level model, allowing the relative transition strengths to be determined for individual centers. The results show that all-optical control of single spins is possible in diamond.
Broadband, Polarization-Insensitive, and Wide-Angle Optical Absorber Based on Fractal Plasmonics (2016)

In this letter, a plasmonic absorber consisting of a metal-dielectric-metal stack with a top layer of Sierpinski nanocarpet is theoretically investigated. Such a compact absorber depicts broadband angle-independent behavior over a wide optical wavelength range (400-700 nm) and a broad range of incidence angles (0°-80°). Including several feature sizes, such a fractal-like structure shows an average simulated extinction response of 0.85 for either transverse electric or magnetic polarization states under normal incidence. Underlying mechanisms of absorbance due to excited surface plasmon modes as well as electric/magnetic dipole resonances are well revealed by investigating electric field, magnetic field, and current distributions. The proposed absorber opens a path to realize high-performance ultrathin light trapping devices.
Research and Development of Novel Anti-thrombotic Agents. New anticoagulants. (2000)

新しい抗血栓薬の開発は,臨床ニーズの高まりと血栓症発症機序の解明を基盤として,遺伝子工学技術の発展とともに展開してきた.抗凝固薬としては,ワーファリンとヘパリンが種々の血栓塞栓性疾患に従来から繁用されており,その有用性は確立している.しかし前者は治療域が狭く用量依存性に個人差が大きく,薬物相互作用や食事の影響を受けやすいなどの問題点が指摘されている.また後者は,治療域が狭く出血の危険性が高く,効果発現が血中アンチトロンビンIII濃度に依存することや抗体産生による血小板減少症惹起などの問題点が指摘されている.したがってこれらの薬薬を使用する場合には,重篤な出血性の副作用を回避するため,凝血学的検査により抗凝固能をモニターすることが必要とされている.近年,これらの問題点を克服すべく新しい抗凝固薬の開発が行われている.これらには,トロンビン,Xa因子,IXa因子,VIIa因子/組織因子の阻害薬,あるいはプロテインC抗凝固経路の充進薬が挙げられ,静注薬のトロンビン阻害薬,トロンボモジュリン,プロテインCおよび活性化プロテインCはすでに上市あるいは臨床試験段階にある.また,経口薬のトロンビン阻害薬やXa阻害薬は現在臨床試験段階にあり,近い将来,ワーファリンに代わる血栓塞栓性疾患の治療薬として登場してくるであろう.この目標に向って,高い経口吸収性を示す化合物の探索競争が熾烈をきわめている.近い将来これらの薬薬の登場により,各種血栓症に対する抗凝固療法も大きく様変わりしていくことであろう.
Method and apparatus for advanced staged combustion utilizing forced internal recirculation (2023)

A method and apparatus for combustion of a fuel in which a first-stage fuel and a first-stage oxidant are introduced into a combustion chamber and ignited, forming a primary combustion zone. At least about 5% of the total heat output produced by combustion of the first-stage fuel and the first-stage oxidant is removed from the primary combustion zone, forming cooled first-stage combustion products. A portion of the cooled first-stage combustion products from a downstream region of the primary combustion zone is recirculated to an upstream region of primary combustion zone. A second-stage fuel is introduced into the combustion chamber downstream of the primary combustion zone and ignited, forming a secondary combustion zone. At least about 5% of the heat from the secondary combustion zone is removed. In accordance with one embodiment, a third-stage oxidant is introduced into the combustion chamber downstream of the secondary combustion zone, forming a tertiary combustion zone.
Fibre Nonlinearity Limitations of 1 Tbps (10x100 Gbps) Multi-Band e-OFDM Super-Channel (2016)

We investigate the influence of fibre nonlinear effects on the performance of a 1 Tbps (10×100 Gbps) 16QAM coherent multi-band e-OFDM super-channel propagating over 1000-km (10×100 km) of uncompensated G.652 fibre line. We demonstrate how FWM and XPM impact the performance of e-OFDM, and clearly show that PAPR is not the relevant limiting factor.
Structurally Stable Manganese Alkoxide Films Grown by Hybrid Molecular Layer Deposition for Electrochemical Applications (2019)

Abstract Hybrid molecular layer deposition (MLD) has significant potential for the creation of ultrathin electrochemically active materials, due to its ability to combine organic and inorganic species to modulate film properties. However, only a limited number of hybrid MLD processes are demonstrated with electrochemically relevant elements, such as manganese. Here, a “manganicone” manganese hybrid MLD chemistry is developed using the precursors bis(ethylcyclopentadienyl)manganese and ethylene glycol. The resulting manganese alkoxide coordination networks are shown to have many interesting properties, including the ability to seamlessly fill high aspect ratio vias and the chemical conversion into manganese carboxylate in air over several hours at room temperature. Linear, self‐saturating growth is reported. Importantly, hybrid manganicone films annealed to 480 °C in air demonstrate a greater stability to restructuring during electrochemical testing than their inorganic counterparts grown by atomic layer deposition, without reducing the activity of the reactive sites on the manganese surface. Thus, hybrid manganese films grown by MLD have significant promise for use as catalysts for the oxygen evolution reaction and as electrodes in thin film batteries.
Is haemoglobin A1c a step forward for diagnosing diabetes? (2009)

Eric Kilpatrick, Zachary Bloomgarden, and Paul Zimmet question proposals to diagnose diabetes by raised glycated haemoglobin concentration rather than glucose testing
Highly Efficient Ambient Temperature CO2 Photomethanation Catalyzed by Nanostructured RuO2 on Silicon Photonic Crystal Support (2018)

Abstract Sunlight‐driven catalytic hydrogenation of CO 2 is an important reaction that generates useful chemicals and fuels and if operated at industrial scales can decrease greenhouse gas CO 2 emissions into the atmosphere. In this work, the photomethanation of CO 2 over highly dispersed nanostructured RuO 2 catalysts on 3D silicon photonic crystal supports, achieving impressive conversion rates as high as 4.4 mmol g cat −1 h −1 at ambient temperatures under high‐intensity solar simulated irradiation, is reported. This performance is an order of magnitude greater than photomethanation rates achieved over control samples made of nanostructured RuO 2 on silicon wafers. The high absorption and unique light‐harvesting properties of the silicon photonic crystal across the entire solar spectral wavelength range coupled with its large surface area are proposed to be responsible for the high methanation rates of the RuO 2 photocatalyst. A density functional theory study on the reaction of CO 2 with H 2 revealed that H 2 splits on the surface of the RuO 2 to form hydroxyl groups that participate in the overall photomethanation process.
Fluoroscopy-Based 3-D Reconstruction of Femoral Bone Cement: A New Approach for Revision Total Hip Replacement (2005)

In revision total hip replacement the removal of the distal femoral bone cement can be a time consuming and risky operation due to the difficulty in determining the three-dimensional (3-D) boundary of the cement. We present a new approach to reconstruct the bone cement volume by using just a small number of calibrated multiplanar X-ray images. The modular system design allows the surgeon to react intraoperatively to problems arising during the individual situation. When encountering problems during conventional cement removal, the system can be used on demand to acquire a few calibrated X-ray images. After a semi-automatic segmentation and 3-D reconstruction of the cement with a deformable model, the system guides the surgeon through a free-hand navigated or robot-assisted cement removal. The experimental evaluation using plastic test implants cemented into anatomic specimen of human femoral bone has shown the potential of this method with a maximal error of 1.2 mm (0.5 mm RMS) for the distal cement based on just 4-5 multiplanar X-ray images. A first test of the complete system, comparing the 3-D-reconstruction with a computed tompgraphy data set, confirmed these results with a mean error about 1 mm.
Identification of Authentic GNSS Signals in Time-Differenced Carrier Phase Measurements with a Multi-Constellation Software Defined Radio Receiver (2023)

Time-differenced carrier phase can be computed with measurements and navigation data recorded by a multi-GNSS SDR receiver such as PyChips, from which user displacement and receiver clock drift can be solved. A random sample consensus algorithm has been developed to check consistency among measurements and data. This algorithm can successfully identify inauthentic measurements from a multi-frequency GNSS dataset, even if inauthentic satellite orbital/clock data are used.
Abstract 17928: Upregulation of Type 1 Angiotensin Ii Receptor in Arterioles is Associated With the Hypertension in D3 Dopamine Receptor Heterozygous Mice (2010)

D3 dopamine receptor (D3R) homozygous (D3−/−) and heterozygous knockout (D3−/+) mice have renin-dependent hypertension that is normalized by type 1 angiotensin II (AngII) receptor (AT1R) blockade; ...
Humeral metastasis as the only recurrence of a 5-year resected gastrointestinal stromal tumor: a case report (2021)

Bones are one of the rarest locations of gastrointestinal stromal tumor metastasis. A multidisciplinary collaboration was set up to allow conservative surgery of our patient after several months of imatinib treatment. A year and a half later, the patient is still in complete remission. This specific case supports the concept of an intermediate stage between local and oligometastatic disease that should be managed with a curative aim, as much as possible.
9.6 A 42.2Gb/s 4.3pJ/b 60GHz Digital Transmitter with 12b/Symbol Polarization MIMO (2019)

With an intent to galvanize high-speed wireless PAN connectivity in modern-day handheld computing devices around the unlicensed 57-to-71GHz band, the IEEE 802.11ay standard [1] supports 2-to-4× bonding of 2.16GHz channels (i.e. 4.32 to 8.64GHz), constellations up to 64QAM, and spatial MIMO. To support such wideband TX, prior linear 60GHz solutions [2] employ baseband modulation followed by a linear upconversion and PA with saturated power of ~10dBm. For OFDM and high-order single-carrier (SC) modulations, the PA operates in significant power back-off, leading to poor average output-to-DC (Pout-to-Pdc) power efficiency (<;1.5%). Additionally, for spectral compliance, these solutions use off-chip pulse-shaping with 8-to-12b, 25-to-65GS/s arbitrary waveform generators (AWG). Implementing such high-performance DACs on-chip would incur significant power overhead in handheld devices.
A TCP-like adaptive contention window scheme for WLAN (2004)

It has been postulated that gonadotropin-releasing hormone (GnRH) analogues may act directly on endometrial cells and inhibit their growth and proliferation by regulation of apoptotic and angiogenic mechanisms. Eutopic endometrial cells from patients with endometriosis show an increased proliferation rate and are less susceptible to cell death by apoptosis than those from subjects without the disease. Notably, the GnRH analogue, leuprorelin, inhibits cell proliferation and increases the apoptotic rate in eutopic endometrial cell cultures, an effect that appears to be mediated by an increase in the expression of the pro-apoptotic proteins Bax and FasL and a decrease in the expression of the anti-apoptotic protein Bcl-2. Angiogenesis is an important process in the development of endometrial tissue, and it is regulated by vascular endothelial growth factors (VEGFs) and angiopoietins. VEGF levels are elevated in peritoneal fluid and endometriotic tissue from patients with endometriosis. In addition, it has been demonstrated that the expression of VEGF is potentiated by a variety of cytokines, including IL-1beta. Recent studies show that leuprorelin reduces the production of VEGF-A and IL-1beta in eutopic endometrial cell cultures, suggesting a mechanism by which it could inhibit the development of endometriosis. Thus, GnRH analogues appear to be effective in reducing the growth of endometrial cells, not only due to their classical pituitary endocrine effects, but also via a direct effect on the endometrial cells themselves.
Optical trapping and micromanipulation using microbeam shaping created by micro-optical elements (2005)

Optical trapping and manipulation are based on three types of the force and momentum, in the range of pN, to grab, lift and rotate microparticles due to the light intensity or phase distribution. In the first type, particles are trapped in the highest intensity region of the beam due to optical gradient force for high refractive index particles with respective to its surrounding medium. Secondly, orbital angular momentum (OAM) of a beam can be transferred to a particle due to phase singularity within a beam. Thirdly, spin angular momentum (SAM) can be transferred to the particles due to the circular polarization of the beam. In recent years, microfabricated optical elements have been used to modulate the amplitude and phase of the optical beam to create new generation of optical tweezers with additional manipulation dimensions. In this paper, a review of our recent discoveries of optical trapping and manipulation using micro-beam shaping and micro-optical elements will be presented.
LASER SHOCK COMPRESSION AND SPALLING OF REACTIVE NI-AL LAMINATE COMPOSITES (2009)

Reactive laminates produced by successive rolling and consisting of alternate layers of Ni and Al (with bi‐layer thicknesses of 5 and 30 μm) were investigated by subjecting them to laser shock‐wave loading. The laser intensity was varied between ∼2.68×1011 W/cm2 (providing an initial estimated pressure P∼25 GPa) and ∼1.28×1013 W/cm2 (P∼333 GPa) with two distinct initial pulse durations: 3 ns and 8 ns. Hydrodynamic calculations (using commercial code HYADES) were conducted to simulate the behavior of shock‐wave propagation in the laminate structures. SEM, and XRD were carried out on the samples to study the reaction initiation, and the intermetallic compounds. It was found that the thinner bilayer thickness (5 μm) laminate exhibited the most intensive localized interfacial reaction at the higher laser intensity (1.28×1013 W/cm2); the reaction products were identified as NiAl and other Al‐rich intermetallic compounds. The reaction front and the formation of intermetallic compounds extend into the sample with a thinner bilayer thickness (5 μm) to a depth of about 50 μm. Increase in the duration of laser shock wave induces increased reaction, which occurs also in the thicker bilayer laminate samples (30 μm bi‐layer thickness). It is demonstrated that the methodology of laser shock is well suited to investigate the threshold conditions for dynamic mechanical reaction initiation caused by high intensity laser irradiation.
Shake table testing and numerical simulation of a self‐centering energy dissipative braced frame (2013)

SUMMARY The self‐centering energy dissipative (SCED) brace is a new steel bracing member that provides both damping to the structure and a re‐centering capability. The goal of this study was to confirm the behavior of SCED braces within complete structural systems and to confirm the ability to model these systems with both a state‐of‐the‐art computer model as well as a simplified model that would be useful to practicing engineers. To these ends, a three‐story SCED‐braced frame was designed and constructed for testing on a shake table. Two concurrent computer models of the entire frame were constructed: one using the opensees nonlinear dynamic modeling software, and a simplified model using the commercial structural analysis software sap2000 . The frame specimen was subjected to 12 significant earthquakes without any adjustment or modification between the tests. The SCED braces prevented residual drifts in the frame, as designed, and did not show any significant degradation due to wear. Both numerical models were able to predict the drifts, story shears, and column forces well. Peak story accelerations were overestimated in the models; this effect was found to be caused by the absence of transitions at stiffness changes in the hysteretic model of the braces. Copyright © 2013 John Wiley &amp; Sons, Ltd.