gebhart/patrepeval huggingface dataset:
Postoperative Mortality After Surgery for Brain Tumors by Patient Insurance Status in the United States (2012)

Uninsured patients who underwent craniotomy for a brain tumor experienced the highest in-hospital mortality. Differences in overall health do not fully account for this disparity.
Supplementary Table 1 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner (2023)

&lt;p&gt;PDF file - 674K, Cells labeled with tumor type of NSCLC have an undetermined histotype. Genes listed in the table have mutations in the tumor lines marked with +, determined by sequencing by the Sanger Center (Forbes et al., 2001). Tumor types are as follows, adenocarcinoma (AC), squamous cell carcinoma (SCC), large cell carcinoma (LCC), tumors with undefined histo-subtype are simply labeled as NSCLC.&lt;/p&gt;
DNA methylation analysis in self-sampled brush material as a triage test in hrHPV-positive women (2014)

DNA methylation analysis as a triage test in hrHPV-positive women is an attractive alternative to cytology. Furthermore, DNA methylation is feasible directly on brush-based self-samplers and showed good correlation with matched physician-taken samples. Direct molecular triage on self-collected specimens could optimise the screening program, especially for non-responders, as this would eliminate the need for an additional physician-taken scraping for triage testing.
pH‐Dependent Conformational Switching in 2,6‐Benzamidodiphenylacetylenes (2011)

The conformational equilibrium of a pH-dependent switch based on an intramolecularly H-bonded diphenylacetylene can be predictably biased by using electron-donating or -withdrawing groups. Furthermore, protonation of the electron-donating dimethylamino group converts it into an electron-withdrawing dimethylammonium cation with a concomitant switch in conformation.
A signature test framework for rapid production testing of RF circuits (2003)

Production test costs for today's RF circuits are rapidly escalating. Two factors are responsible for this cost escalation: (a) the high cost of RF ATEs and (b) long test times required by elaborate performance tests. In this paper, we propose a framework for low-cost signature test of RF circuits using modulation of a baseband test signal and subsequent demodulation of the DUT response. The demodulated response of the DUT is used as a "signature" from which all the performance specifications are predicted. The applied test signal is optimized in such a way that the error between the measured DUT performances and the predicted DUT performances is minimized. The proposed low-cost solution can be easily built into a load board that can be interfaced to an inexpensive tester.
Adaptive Multi-Connectivity Scheduling for Reliable Low-Latency Communication in 802.11be (2022)

The demand for wireless communication systems that provide low latency with high reliability is growing due to emerging applications such as wireless industrial control or mobile robotics. A promising approach to improve latency and reliability performance of wireless communications is Multi-Connectivity (MC), i.e., using multiple communication paths at the same time. The task group working on the upcoming 802.11be amendment is discussing multi-link operation as one of the main features. In previous work different static MC scheduling schemes have been evaluated and in different scenarios different schemes demonstrated to provide the best latency and reliability performance. Based on these findings and in coherence with the discussion about multi-link operation in the 802.11be task group an adaptive MC scheduling scheme is proposed in this work. Two variants are proposed and both perform a client-based decision. The first variant decides solely based on the parameters available at every station itself. The second variant also takes into account additional information about the network that are gathered and shared with the stations by the AP. System level simulations with ns-3 for an industrial scenario show that the adaptive MC schemes can significantly improve the latency and reliability performance, especially in scenarios with medium network load. The insights gained in this work can be used to develop multi-link operation concepts in order to improve latency and reliability performance in the upcoming 802.11be amendment.
Double-barrier superlattice infrared photodetector combined with quantum well infrared photodetector for operation at high temperature and low bias (2009)

We have designed a double-barrier superlattice infrared photodetector combined with quantum well infrared photodetector which has a superlattice (SL) sandwiched between the thick and graded barriers then multiple quantum wells(MQWs) are inserted in the right side of them . The two barriers can let the photoelectrons to bounce back and forth then the photoelectrons inject through the MQWs which are used as noise filter. The detector shows high-temperature operation (~110 K) at low bias. The associated detectivity is also optimized so this device is the promising candidate of a pixel in the focal plane array.
Implications of blood-brain barrier disruption in ALS (2008)

Our letter to the editor addresses important questions regarding the role of the blood-spinal cord barrier in amyotrophic lateral sclerosis. The novel finding of barrier dysfunction in ALS has implications for disease pathogenesis. This discussion should prove of widespread interest to researchers and may help in formulating various new therapeutic strategies to protect barrier function and thus extend functionality and lifespan in ALS patients.
<title>Implementing a real-time chain of segmentation of images on a multi-FPGA architecture</title> (1998)

In this paper we present the study and the implementation of an optimized chain of segmentation operators. We implemented this chain in real time, consisting of a Deriche contour detection, double threshold, closing of contours and finally region labeling, on a multi-FPGA architecture. This architecture has four processing FPGAs and four memory modules. Deriche operator, closing of contours and labeling occupy each one an FPGA. Double threshold and detection of the extremities filled partially the forth FPGA. The slowest component of the chain is Deriche operator which can go up to 11.4 Mhz, assuring the process of an image every 40 ms. Deriche operator tries to extract the contours by assuming that a contour is a step super positioned by a white gaussian noise. Our implementation consists of a smoothing part of four second order filters and a Sobel as a derivation part. The second order filters are causal and non-causal horizontal and vertical operators. The gradient image passes through a double threshold filter to select the real contours and the crests and the background pixels. Closing of contours eliminates the false crests and finally the labeling gives a unique label to each closed region. The latency of the chain is in the order of three images. This implementation shows the efficiency of the chain and also it demonstrates the capabilities of our architecture as a prototyping system.
ChemInform Abstract: Selective Dopamine D‐2 Autoreceptor Agonists with 8‐Azaindole Substructure: Synthesis and Theoretical Investigations. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Molecular Mechanism of Zinc Action, and a Note on the Treatment of SLE in the Mouse with Zinc (1982)

We believe a major clue as to the molecular mechanism of zinc action at pharmacological dosage levels can be derived from the existence of zinc-calcium antagonism (Brewer, 1980). Since we have considerable information about the molecular mechanism of calcium action, zinc antagonism to those actions suggests that we explore the possibility of a related molecular mechanism of action for zinc.
Structural Change of Cellulose Nanofibers in Supercapacitor Electrodes during Galvanostatic Cycling (2015)

Graphene and other carbon-based materials are often used as electrodes in electrochemical double-layer supercapacitors (EDLCs), due to their ability to store electrical energy. Cellulose nanofibers (CNF) have been proven to be suitable as a dispersion agent and binder in graphite based electrodes for supercapacitor applications, especially due to their capability to improve the wet and dry strength of the electrode. At the same time the capacitance is maintained or even increased with addition of CNF. It is reasonable to believe that the addition of CNF manages to stabilize smaller graphite particles in the dispersion which results in larger internal surface area in the dry material. When the amount of CNF is around 20 wt%, (in ratio to the total mass of active material), both scanning electron microscopy and XPS analysis showed that the surface is almost completely covered with the nano-cellulose. Even with this isolating layer of cellulose it is interesting to note that the capacitance is as high as 90 F/g, compared to around 50 F/g for the lowest CNF amount of 5 wt%. However, by applying voltage pulses during the galvanostatic cycling procedure for capacitance measurements, an initial transient behavior is observed during the first cycles. Therefore the capacitance is calculated after 4000 charge and discharge curves, when curves are completely stabilized. We found that the electrode structure changes significantly during this capacitance measurement and already after a short pulse of 10 s and 0.3 V the structural change is noticeable. After cycling for 24 hours, a completely new structure emerges where large fiber-like structures are developed with diameters around 20-30 µm. The galvanostatic cycling procedure has created fiber-like cellulose structures around 1000 times larger than the initial size of the nano-cellulose. Structural properties of the electrode have often been related to the electronic properties in the supercapacitor. Our result shows that due to this change in the CNF structure, the electrode properties after galvanostatic cycling are indeed also of interest to study. This structural change might be critical to device performance and durability.
High-Resolution Compton Scattering Study of Li: Asphericity of the Fermi Surface and Electron Correlation Effects (1995)

We present high-resolution Compton scattering spectra from Li single crystals together with corresponding highly accurate local-density-approximation (LDA) based computations. The data are analyzed to obtain Fermi surface radii along the three principal symmetry directions; the maximum measured anisotropy is found to be $\left(4.6\ifmmode\pm\else\textpm\fi{}1.0\right)%$. Comparisons between the measured and computed spectra clearly reveal departures from the conventional one-particle LDA picture of the ground state momentum density of the electron gas. This study establishes the potential of Compton scattering as a tool for investigating Fermiology-related issues in materials.
Frequency-narrowed diode array bar (2005)

We describe a method to frequency narrow multielement high-power diode bars. Using a commercial 60-W, 49-element, 1-cm-long diode array bar at 795 nm running at 45 W, we narrow the linewidth from 1000 to 64 GHz with only a loss of 33% in output power. The resulting laser light is well suited for spin-exchange optical pumping of noble gas nuclei.
Characterization of different bubble formulations for blood-brain barrier opening using a focused ultrasound system with acoustic feedback control (2018)

Focused ultrasound combined with bubble-based agents serves as a non-invasive way to open the blood-brain barrier (BBB). Passive acoustic detection was well studied recently to monitor the acoustic emissions induced by the bubbles under ultrasound energy, but the ability to perform reliable BBB opening with a real-time feedback control algorithm has not been fully evaluated. This study focuses on characterizing the acoustic emissions of different types of bubbles: Optison, Definity, and a custom-made nanobubble. Their performance on reliable BBB opening under real-time feedback control based on acoustic detection was evaluated both in-vitro and in-vivo. The experiments were conducted using a 0.5 MHz focused ultrasound transducer with in-vivo focal pressure ranges from 0.1-0.7 MPa. Successful feedback control was achieved with all three agents when combining with infusion injection. Localized opening was confirmed with Evans blue dye leakage. Microscopic images were acquired to review the opening effects. Under similar total gas volume, nanobubble showed a more reliable opening effect compared to Optison and Definity (p < 0.05). The conclusions obtained from this study confirm the possibilities of performing stable opening using a feedback control algorithm combined with infusion injection. It also opens another potential research area of BBB opening using sub-micron bubbles.
Ultra Wide Band SAW Resonator Composed of Grooved Cu Electrodes and its Application to Tunable Filters (2011)

A cognitive radio system, which is researched to use a limited frequency resource effectively, requires a tunable filter with a wide variable frequency range. A resonator with wide band is required to realize the tunable filter. It was reported that a resonator composed of a Cu-electrode/15°YX-LiNbO3 had wide bandwidth of 12%. This time, authors attempted to fabricate an one-port resonator composed of a grooved Cu-electrode/4°YX-LiNbO3. As the result, it had a wider bandwidth of 17% of 1.3 times than that on Cu electrode/4°YX-LiNbO3. This resonator was applied to a tunable filter, and as the results, the tunable filter having tunable range of 6.8% in center frequency was experimentally realized using a band pass filter type circuit, and those having tunable range of 9 to 12% theoretically using a ladder type circuit.
ChemInform Abstract: Synthesis and Biophysical Properties of Constrained D‐Altritol Nucleic Acids (cANA). (2014)

Abstract Constrained altritol nucleotide derivatives (I) are incorporated into antisense oligonucleotides (ASO) in order to study how conformationally restricting the D‐altritol backbone‐containing ASO will affect their ability to form duplexes with RNA.
Supplementary Tables S1-S4 from MMP16 Mediates a Proteolytic Switch to Promote Cell–Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma (2023)

&lt;p&gt;Supplementary Tables S1-S4. MMPs which are significantly over-expressed in melanoma cell lines compared to the mean expression of all cancer cell lines in the datasets with over 15 melanoma cell lines (S1); Outlier analysis of MMP16 copy number gain or over-expression using DNA and mRNA datasets containing more than 20 clinical melanoma samples (S2); MMP mRNA expression, LVI and clinicopathological data of human melanoma tumors (S3); S100B staining coverage, lymphatic and blood vessel densities of human melanoma tumors (S4)&lt;/p&gt;
Interference Evaluation in Multi-Cell Environment with Resource Allocation Algorithms (2008)

Adaptive multi-user resource allocation is one of the most promising technological breakthroughs that could improve performance of future broadband wireless communications. In a multi-cell scenario, where co-channel interference is the performance limiting factor, resource allocation algorithms select those channels with best Signal-to Interference and Noise-Ratio (SINR) and adapt transmission power, acting indirectly on the interference levels. The paper introduces an analytical procedure for evaluating how the distribution of co-channel interference is modified by different resource allocation algorithms. This procedure can be used for deriving a model of interference or for providing a deeper insight on the performance limits of the system.
Occult pulmonary hemorrhage in anticoagulated patients. (1975)

Evidence for severe intrapulmonary bleeding was obtained in 3 anticoagulated patients who presented with pulmonary infiltrates. The diagnosis of pulmonary hemorrhage was based on findings of markedly elevated quantities of stainable hemosiderin and hemoglobin in alveolar macrophages retrieved by bronchopulmonary lavage. In 2 of the patients, roentgenographic abnormalities regressed after anticoagulation was reversed. The third patient died and massive bilateral pulmonary hemorrhage was found at autopsy. The syndrome of occult pulmonary hemorrhage was characterized clinically by dyspnea, unexplained acute anemia, and infiltrates with an alveolar pattern on chest roentgenogram. Hemoptysis was conspicuously absent. Bronchopulmonary lavage and quantification of alveolar macrophage hemosiderin content may be useful in identifying intrapulmonary bleeding occurring in an otherwise occult manner. Recognition of pulmonary hemorrage in anticoagulated patients is important because reversal of anticoagulation can be life saving.
Optimum classifier for M-ary PSK signals (2002)

An optimum classifier is designed to classify the general M-ary phase-shift keyed (MPSK) signal buried in additive white Gaussian noise. The classification problem is treated as an N-ary (N=1+log/sub 2/ M) hypothesis testing problem, and the performance of this optimum classifier is expressed in terms of the probability of misclassification. One case illustrates the capability of this classifier, and this optimum classifier and several other algorithms are compared. The structure of this classifier is flexible and is easy to expand. Theoretical analysis shows that for a finite observation interval the performance of this proposed classifier is reasonable even in a noisy environment. Further improvement in performance can be obtained by increasing the length of the observation interval.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Display supersampling (2009)

Supersampling is widely used by graphics hardware to render anti-aliased images. In conventional supersampling, multiple scene samples are computationally combined to produce a single screen pixel. We consider a novel imaging paradigm that we call display supersampling , where multiple display samples are physically combined via the superimposition of multiple image subframes. Conventional anti-aliasing and texture mapping techniques are shown inadequate for the task of rendering high-quality images on supersampled displays. Instead of requiring anti-aliasing filters, supersampled displays actually require alias generation filters to cancel the aliasing introduced by nonuniform sampling. We present fundamental theory and efficient algorithms for the real-time rendering of high-resolution anti-aliased images on supersampled displays. We show that significant image quality gains are achievable by taking advantage of display supersampling. We prove that alias-free resolution beyond the Nyquist limits of a single subframe may be achieved by designing a bank of alias-canceling rendering filters. In addition, we derive a practical noniterative filter bank approach to real-time rendering and discuss implementations on commodity graphics hardware.
Resonant coupling of surface plasmons to radiation modes by use of dielectric gratings (2003)

Efficient outcoupling of surface-plasma waves to radiation modes by use of dielectric diffraction gratings on a flat metallic surface is discussed. The dielectric gratings, which have a surface-relief structure with only several tens of nanometers in peak-to-trough height on a flat metal surface, can efficiently extract radiation modes propagating in free space from the surface-plasmon modes. An outcoupling efficiency of 50% is estimated with the rigorous coupled-wave diffraction theory, and it is confirmed by the experiment.
Time-resolved fluorescence microscopy with phasor analysis for visualizing multicomponent topical drug distribution within human skin (2020)

Understanding a drug candidate's pharmacokinetic (PK) parameters is a challenging but essential aspect of drug development. Investigating the penetration and distribution of a topical drug's active pharmaceutical ingredient (API) allows for evaluating drug delivery and efficacy, which is necessary to ensure drug viability. A topical gel (BPX-05) was recently developed to treat moderate to severe acne vulgaris by directly delivering the combination of the topical antibiotic minocycline and the retinoid tazarotene to the pilosebaceous unit of the dermis. In order to evaluate the uptake of APIs within human facial skin and confirm accurate drug delivery, a selective visualization method to monitor and quantify local drug distributions within the skin was developed. This approach uses fluorescence lifetime imaging microscopy (FLIM) paired with a multicomponent phasor analysis algorithm to visualize drug localization. As minocycline and tazarotene have distinct fluorescence lifetimes from the lifetime of the skin's autofluorescence, these two APIs are viable targets for distinct visualization via FLIM. Here, we demonstrate that the analysis of the resulting FLIM output can be used to determine local distributions of minocycline and tazarotene within the skin. This approach is generalizable and can be applied to many multicomponent fluorescence lifetime imaging targets that require cellular resolution and molecular specificity.
Abstract 16653: Bioequivalence of Chemoenzymatically Synthesized Bioengineered Heparin versus Porcine USP Heparins (2013)

Although most pharmaceutical heparin used today is obtained from porcine intestine, heparin has historically been prepared from bovine lung and ovine intestine. There is some regulatory concern abo...
Front Matter: Volume 6629 (2007)

This PDF file contains the front matter associated with SPIE-OSA Biomedical Optics Proceedings Volume 6629, including the Title Page, Copyright information, Table of Contents, Introduction (if any), and the Conference Committee listing.
Reactions of 3,3-Diphenylcyclopropene with Iridium(I) Complexes: Probing the Mechanism of Cyclopropene Rearrangements at Transition Metal Centers (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of 3,3-Diphenylcyclopropene with Iridium(I) Complexes: Probing the Mechanism of Cyclopropene Rearrangements at Transition Metal CentersRobert T. Li, SonBinh T. Nguyen, Robert H. Grubbs, and Joseph W. ZillerCite this: J. Am. Chem. Soc. 1994, 116, 22, 10032–10040Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/ja00101a023https://doi.org/10.1021/ja00101a023research-articleACS PublicationsRequest reuse permissionsArticle Views580Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts