gebhart/patrepeval huggingface dataset:
Subband adaptive filtering for acoustic echo control using allpass polyphase IIR filterbanks (1998)

Adaptive filtering in subbands is an attractive alternative to full-band schemes in many applications because of the potential for faster convergence and lower computational cost. However, the analysis of a signal into a subband representation and the synthesis back into its original full-band form carries three main penalties. These are that (1) the subsampling process often introduces aliasing, (2) the subband analysis and synthesis processes carry a computational overhead, thereby reducing the gain in efficiency, and (3) the subband analysis and synthesis processes introduce delay into the signal path. A subband scheme is presented that aims to minimize these penalties, thereby allowing the potential advantages of the subband approach to be more fully realized. The scheme is based on infinite impulse response (IIR) filterbanks, formed from allpass polyphase filters, which exhibit very high quality filtering compared to typical finite impulse response (FIR) implementations, have relatively low complexity, introduce a limited degree of phase distortion and have low delay. The scheme, in conjunction with normalized least mean squares (NLMS) adaptive filters, is tested in an acoustic echo control application and shown to give better convergence, lower delay, and lower computational cost than a comparable FIR subband scheme.
Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva (2020)

Abstract Currently, no effective therapies exist for fibrodysplasia ossificans progressiva (FOP), a rare congenital syndrome in which heterotopic bone is formed in soft tissues due to dysregulated activity of the bone morphogenetic protein (BMP) receptor kinase ALK2/ ACVR1 . From a screen of known biologically active compounds, we identified saracatinib as a potent ALK2 kinase inhibitor. In enzymatic and cell-based assays, saracatinib preferentially inhibited ALK2 compared with other receptors of the BMP/TGFβ signaling pathway, and induced dorsalization in zebrafish embryos consistent with BMP antagonism. We further tested the efficacy of saracatinib using an inducible ACVR1 Q207D transgenic mouse line, which provides a model of heterotopic ossification, as well as an inducible ACVR1 R206H knock-in, which serves as a genetically and physiologically faithful model of FOP. In both models, saracatinib was well tolerated and potently inhibited the development of heterotopic ossification even when administered transiently following soft tissue injury. Together, these data suggest that saracatinib is an efficacious clinical candidate for repositioning in the treatment of FOP, offering an accelerated path to clinical proof of efficacy studies and potentially significant benefits to individuals with this devastating condition.
Computational and Experimental Validation of a Vortex-Superposition-Based Buoyancy Approximation for the COMPACT Code in Data Centers (2013)

A simplified model and GUI package, named COMPACT (Compact Model of Potential Flow and Convective Transport), has been developed in previous years to provide a fast alternative to full computational fluid dynamic (CFD) thermofluidic models for a variety of data center applications. These include, but are not limited to, use as a first-order design tool, a potential improvement to plant-based controllers, and an initial guess for complex CFD solvers. COMPACT applies convective energy transport equations to a computed potential flow field to approximate a flow and temperature field, taking 30 s or less for a commercially available laptop to characterize a 7700 cell room. Previously, the results from this model were compared to experimental measurements taken from a data center at Hewlett-Packard Laboratories (HP Labs) in Palo Alto, CA. High localized temperatures in the model led to the conclusion that recirculation and buoyancy were contributing excessively to error in the model. This paper proposes a method of vortex superposition to account for these effects, in which locations with high temperature in the original model are analyzed and a corrective flow field consisting of Rankine vortices is superimposed on the solution. This approach is tested with further experimental measurements taken from the data center at HP Labs, as well as conventional commercially available CFD. These newer results show a marked decrease in mean deviation of the model from measured temperatures, as well as elimination of the highly localized temperatures which afflicted the original COMPACT results. The vortex superposition model is also “tuned,” with vortex strength optimized for multiple test cases at varying levels of recirculation.
MIMO-OFDM Training Signal Design in the Presence of Frequency Offset and Phase Noise (2006)

All existing training signal designs for channel estimation in OFDM systems neglect phase noise or both frequency offsets and phase noise. In practice, frequency offset and phase noise are unavoidable and can seriously degrade the performance of OFDM systems. In this paper, we address the problem of designing optimal training signals for the estimation of frequency-selective channels in MIMO OFDM systems with frequency offset and phase noise. Analytical and simulation results for the corresponding channel estimation mean square error are presented. Channel estimation performance is more sensitive to frequency offset and phase noise in MIMO than in SISO OFDM systems. The performance improvement achieved by the proposed training signals becomes more significant for moderate-to-high values of SNR, frequency offset, and phase noise level
On two‐way Bayesian agglomerative clustering of gene expression data (2012)

Abstract This article introduces an agglomerative Bayesian model‐based clustering algorithm which outputs a nested sequence of two‐way cluster configurations for an input matrix of data. Each two‐way cluster configuration in the output hierarchy is specified by a row configuration and a column configuration whose Cartesian product partitions the data matrix. Variable selection is incorporated into the algorithm by identifying row clusters which form distinct groups defined by the column clusters, through the use of a mixture model. A primitive similarity measure between the two clusters is the multiplicative change in model posterior probability implied by their merger, and the hierarchy is formed by iteratively merging the cluster pair which maximize some fixed monotonic function of this quantity. A naive implementation of the algorithm would be to choose this function to be the identity function. However, when applying this naive algorithm to gene expression data where the number of genes being studied typically far exceeds the number of experimental samples available, this imbalanced dimensionality of the data results in an algorithmic bias toward merging samples. To counteract this bias, alternative functions of the similarity measure are considered which prevent degenerative behavior of the algorithm. The resulting improvements in the output cluster configurations are demonstrated on simulated data and the method is then applied to real gene expression data. © 2012 Wiley Periodicals, Inc. Statistical Analysis and Data Mining, 2012
Strong enhancement of the photoluminescence efficiency from InAs quantum dots (2003)

InAs quantum dots (QDs) have been investigated using optical spectroscopy, in order to understand the experimental observation of strong enhancement of their photoluminescence efficiency. When a tunneling barrier is introduced between the InAs layer and the GaAs cap layer, the intensity of the InAs QD emission increases by more than an order of magnitude at the excitation density of 60 W/cm2. The enhancement of the optical recombination efficiency is due to the suppression of the nonradiative transitions in the wetting layer. The strong enhancement of the InAs emission can lead to an increase in the optical gain of the InAs laser structure.
MP63-15 COMPREHENSIVE MOLECULAR CLASSIFICATION OF BLADDER CANCER REVEALS DISTINCT PROGNOSTIC SUBGROUPS WITH DIFFERENT SENSITIVITIES TO IMMUNOTHERAPY (2019)

You have accessJournal of UrologyBladder Cancer: Basic Research & Pathophysiology III (MP63)1 Apr 2019MP63-15 COMPREHENSIVE MOLECULAR CLASSIFICATION OF BLADDER CANCER REVEALS DISTINCT PROGNOSTIC SUBGROUPS WITH DIFFERENT SENSITIVITIES TO IMMUNOTHERAPY Jongsoo Lee*, Doo Yong Chung, Hyeok Jun Goh, Hyun Ho Han, Ji Eun Heo, Jae Won Park, Young Sig Kim, Dong Hoon Lim, Joong Shik Lee, Rae Cho In, Won Sik Jang, Won Sik Ham, Sun-Hee Leem, In-Sun Chu, and Young Deuk Choi Jongsoo Lee*Jongsoo Lee* More articles by this author , Doo Yong ChungDoo Yong Chung More articles by this author , Hyeok Jun GohHyeok Jun Goh More articles by this author , Hyun Ho HanHyun Ho Han More articles by this author , Ji Eun HeoJi Eun Heo More articles by this author , Jae Won ParkJae Won Park More articles by this author , Young Sig KimYoung Sig Kim More articles by this author , Dong Hoon LimDong Hoon Lim More articles by this author , Joong Shik LeeJoong Shik Lee More articles by this author , Rae Cho InRae Cho In More articles by this author , Won Sik JangWon Sik Jang More articles by this author , Won Sik HamWon Sik Ham More articles by this author , Sun-Hee LeemSun-Hee Leem More articles by this author , In-Sun ChuIn-Sun Chu More articles by this author , and Young Deuk ChoiYoung Deuk Choi More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000556858.84811.2eAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail WITHDRAWN Seoul, Korea, Republic of; Goyang, Korea, Republic of; Gwangju, Korea, Republic of; Seoul, Korea, Republic of; Goyang, Korea, Republic of; Seoul, Korea, Republic of; Daejeon, Korea, Republic of; Seoul, Korea, Republic of© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e902-e903 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jongsoo Lee* More articles by this author Doo Yong Chung More articles by this author Hyeok Jun Goh More articles by this author Hyun Ho Han More articles by this author Ji Eun Heo More articles by this author Jae Won Park More articles by this author Young Sig Kim More articles by this author Dong Hoon Lim More articles by this author Joong Shik Lee More articles by this author Rae Cho In More articles by this author Won Sik Jang More articles by this author Won Sik Ham More articles by this author Sun-Hee Leem More articles by this author In-Sun Chu More articles by this author Young Deuk Choi More articles by this author Expand All Advertisement PDF downloadLoading ...
Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases (2004)

Kinins are released from kininogens through the activation of the Hageman factor-prekallikrein system or by tissue kallikrein. These peptides exert various biological activities, such as vascular permeability increase, smooth muscle contraction, pain sensation and induction of hypotension. In many instances kinins are thought to be involved in the pathophysiology of various diseases. Recent studies have revealed that microbial and human cell proteinases activate Hageman factor and/or prekallikrein, or directly release kinin from kininogens. This review discusses the activation of the kinin-release system by mast-cell tryptase and microbial proteinases, including gingipains, which are cysteine proteinases from Porphyromonas gingivalis , the major pathogen of periodontal disease. Each enzyme is evaluated in the context of its association to allergy and infectious diseases, respectively. Furthermore, a novel system of kinin generation directly from kininogens by the concerted action of two proteinases is described. An interesting example of this system with implications to bacterial pathogenicity is the release of kinins from kininogens by neutrophil elastase and a synergistic action of cysteine proteinases from Staphylococcus aureus . This alternative production of kinins by proteinases present in diseased sites indicates a significant contribution of proteinases other than kallikreins in kinin generation. Therefore kinin receptor antagonists and proteinase inhibitors may be useful as therapeutic agents.
Remodeling of the zero-stress state of femoral arteries in response to flow overload (2001)

The goal of this study is to quantitatively describe the remodeling of the zero-stress state of the femoral artery in flow overload. Increased blood flow, approximately as a unit step change, was imposed on the femoral artery by making an arteriovenous (a-v) fistula with the epigastric vein. The a-v fistula was created in the right leg of 36 rats, which were divided equally into six groups (2 days and 1, 2, 4, 8, and 12 wk after the fistula). The vessels in the left leg were used as controls without operative trauma. The in vivo blood pressure, flow, and femoral outer diameter and the in vitro zero-stress state geometry were measured. The in vivo shear rate at the endothelial surface increased approximately as a step function by approximately 83%, after 2 days, compared with the control artery. The arterial luminal and wall area significantly increased postsurgically from 0.15 +/- 0.02 and 0.22 +/- 0.02 mm(2) to 0.28 +/- 0.04 and 0.31 +/- 0.05 mm(2), respectively, after 12 wk. The wall thickness did not change significantly over time (P > 0.1). The opening angle decreased to 82 +/- 4.2 degrees postsurgically when compared with controls (102 +/- 4.4) after 12 wk and correlated linearly with the thickness-to-radius ratio. Histological analysis revealed vascular smooth muscle cell growth. The remodeling data are expressed mathematically in terms of indicial functions, i.e., change of a particular feature of a blood vessel in response to a unit step change of blood flow. The indicial function approach provides a quantitative description of the remodeling process in the blood vessel wall.
Toughening of Dental Composites with Thiourethane-Modified Filler Interfaces (2019)

Stress of polymerization is one of the most significant drawbacks of dental resin composites, since it is related to poor marginal adaptation, postoperative pain, and secondary caries. Previous studies have shown that thiourethane oligomers incorporated into the organic matrix represents a promising strategy to reduce stress and increase fracture toughness in dental composites. However, this strategy promotes a significant increase of the viscosity system, which may represent a challenge for clinical application. The objective of this study was to functionalize the surface of inorganic filler particles with thiouretanes and evaluate the impact on mechanical properties and kinetics of polymerization. Our results showed that composites filled with thiourethane-silanized inorganic fillers showed up to 35% lower stress while doubling mechanical properties values. This was achieved with no prejudice to the viscosity of the material and following a clinically acceptable photoactivation protocol.
Parametric resonance in an expanding universe (1998)

Parametric resonance has been discussed as a mechanism for copious particle production following inflation. Here we present a simple and intuitive calculational method for estimating the efficiency of parametric amplification as a function of parameters. This is important for determining whether resonant amplification plays an important role in the reheating process. We find that significant amplification occurs only for a limited range of couplings and interactions.
Monocytes do not make mast cells when cultured in the presence of SCF. Characterization of the circulating mast cell progenitor as a c- kit +, CD34+, Ly-, CD14-, CD17-, colony-forming cell. (1993)

Mast cells (MC3) belong to the hemopoietic system and arise from hemopoietic precursor cells. Human MC progenitors can be detected in the bone marrow as well as in the peripheral blood (pb) and are responsive to the mast cell growth factor SCF, the ligand of the c-kit tyrosine kinase receptor. However, little is known about the subsets of cells that become committed to and differentiate into mature human MC. In this study, the identity of the circulating MC progenitor, previously felt to be a monocyte (Mo) or basophil (Ba), was investigated. For this purpose, CD14+ pb monocytes, CD17+ pb basophils and CD34+ cord blood cells were purified to homogeneity (> 95%) from mononuclear cells (normal adult donors, n = 17, cord blood, n = 2) by counter-flow centrifugation followed by cell sorting with mAb. In the presence of rhSCF, MC developed in long term suspension culture from pure CD34+ cells but not from pure Mo, pure Ba, or Ly (MC-tryptase levels on day 42: CD14+ Mo: 3.7 +/- 0.8 vs CD17+ Ba: 3.2 +/- 0.5 vs Ly: 2.0 +/- 1.5 vs control: 196.5 +/- 92.5 ng/ml, p < 0.001). Depletion of CD34+ cells from MNC resulted in a loss of MC in long term suspension culture, whereas depletion of either Mo, Ba, or Ly did not. In methyl-cellulose cultures in the presence of rhSCF, MC and tryptase could be detected in pure (CFU-mast) and mixed (CFU-myeloid/mast) MC colonies. Together, MC do not originate from circulating Mo, Ba, or Ly. The circulating MC progenitor is a CD34+, c-kit+, Ly-, CD14-, CD17- colony-forming cell. This is the first definitive demonstration that mast cells are replenished directly from early hemopoietic progenitors and thus form a unique cell lineage within the hemopoietic system.
Single-Trial Speech Suppression of Auditory Cortex Activity in Humans (2010)

The human auditory cortex is engaged in monitoring the speech of interlocutors as well as self-generated speech. During vocalization, auditory cortex activity is reported to be suppressed, an effect often attributed to the influence of an efference copy from motor cortex. Single-unit studies in non-human primates have demonstrated a rich dynamic range of single-trial auditory responses to self-speech consisting of suppressed, nonsuppressed and excited auditory neurons. However, human research using noninvasive methods has only reported suppression of averaged auditory cortex responses to self-generated speech. We addressed this discrepancy by recording electrocorticographic activity from neurosurgical subjects performing auditory repetition tasks. We observed that the degree of suppression varied across different regions of auditory cortex, revealing a variety of suppressed and nonsuppressed responses during vocalization. Importantly, single-trial high-gamma power (γ(High), 70-150 Hz) robustly tracked individual auditory events and exhibited stable responses across trials for suppressed and nonsuppressed regions.
Cloning and expression of the vesicular stomatitis virus phosphoprotein gene in Escherichia coli: analysis of phosphorylation status versus transcriptional activity (1991)

The phosphoprotein (P, previously known as NS) genes of vesicular stomatitis virus serotypes New Jersey and Indiana have been cloned in the Escherichia coli expression vector pET-3a. Transcription of P genes in these clones initiated from a phage T7 RNA polymerase promoter, whereas translation was driven by the Shine-Dalgarno sequence and the initiator AUG codon of the T7 gene 10 message. The clones were introduced into an appropriate E. coli strain in which T7 RNA polymerase was expressed under the control of the lac promoter. Under optimal conditions of induction with isopropylthiogalactopyranoside, P protein made in these bacterial strains constituted 5 to 20% of total cellular protein. P protein expressed in bacteria was unphosphorylated and transcriptionally active in an in vitro reconstitution assay with viral L protein and an N-RNA template. However, the P protein was phosphorylated in vitro by the kinase activities associated with L and the N-RNA template.
P‐186: High Quality Patterned Retarder for Transflective LCDs (2008)

Abstract A patterned retarder for a transflective LCD can be fabricated by photo polymerization of a liquid crystalline monomer. It is required for the retarder that pattern size is smaller than pixel size of a LCD and that retardation of the retarder is thermally stable against over 200°C. We have optimized liquid crystalline monomer and fabrication processes of the retarder to achieve high quality patterned retarder.
Subcell Segmentation for the Optimization of a Four-Subcell Multijunction Solar Cell Design (2020)

Detailed balance calculation of subcell segmentation in the extension of the InGaP/InGaAs/Ge system to 4-subcell designs shows performance above the level of the standard optimal bandgap is achievable in conjunction with other practical advantages.
Integrating Computational and Biochemical Studies to Explore Mechanisms in NF-κB Signaling (2008)

Biochemistry involves the quantitative characterization of molecular mechanisms in biology. Contextualizing in vitro molecular studies within cellular or human physiology and disease is an important and often challenging component. Computational models of reaction networks may be useful in this regard, and recent advances in commercially and freely available software are likely to broaden the impact of this approach. This review will highlight the utility and strategy of integrating biochemical and computational techniques by describing how such an approach was taken to analyze the regulation of NF-κB. 2The abbreviations used are: NF-κB, nuclear factor-κB; IKK, IκB kinase; TNF, tumor necrosis factor; ODE, ordinary differential equation.
Capacitive accelerometer laboratory using polymer-film rapid prototyping technology (2013)

We present a rapid prototyping substitute for silicon MEMS Fabrication, which allows students to understand the fundamental tradeoffs in designing a planar accelerometer. The laboratory uses commercially available polymer-films and a CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> laser cutter for device fabrication and design validation.
Macrolides and Antifungals via Biotransformation (2014)

This chapter contains sections titled: Introduction to Polyketides and Their Activity Mechanism of Polyketide Biosynthesis Conclusions
Stabilization of a mode-locked semiconductor laser optical frequency comb using the Pound-Drever-Hall scheme (2003)

We report optical frequency comb drift stabilization of an external cavity semiconductor laser hybridly modelocked at the 10 GHz cavity fundamental using the Pound-Drever-Hall frequency stabilization scheme. Laser longitudinal mode comb was locked to a Fabry-Perot reference cavity with a finesse value of 214. The frequency error signal was fed back to the bias current of the semiconductor gain medium to change the effective laser cavity length through the coupling between carrier density and refractive index. The peak-to-peak 2.4 GHz frequency drift of the comb of longitudinal modes was reduced to a RMS fluctuation of 30 MHz for up to 5 minutes. To the authors’ knowledge, this is the first optical frequency comb stabilization of a modelocked semiconductor laser. The intended application of the optical frequency stabilization is to keep the laser optical frequency comb locked to a WDM filter that is used for spatially separating the individual longitudinal modes of the laser for photonic arbitrary waveform generation.