gebhart/patrepeval huggingface dataset:
African Swine Fever Virus Protein A238L Interacts with the Cellular Phosphatase Calcineurin via a Binding Domain Similar to That of NFAT (2000)

The African swine fever virus protein A238L inhibits activation of NFAT transcription factor by binding calcineurin and inhibiting its phosphatase activity. NFAT controls the expression of many immunomodulatory proteins. Here we describe a 14-amino-acid region of A238L that is needed and sufficient for binding to calcineurin. By introducing mutations within this region, we have identified a motif (PxIxITxC/S) required for A238L binding to calcineurin; a similar motif is found in NFAT proteins. Peptides corresponding to this domain of A238L bind calcineurin but do not inhibit its phosphatase activity. Binding of A238L to calcineurin stabilizes the A238L protein in cells. Although A238L-mediated suppression of NF-kappaB-dependent gene expression occurs by a different mechanism, the A238L-calcineurin interaction may be required to stabilize A238L.
Second-harmonic controlled all-optical modulation by cascading (2002)

The results presented here give a demonstration of the potential of all-optical switching using X/sup 2/ nonlinearities. The switching irradiance scales as [X/sup 2/]/sup -2/ so that new organic crystals with X/sup 2/ more than ten times that of KTP will significantly reduce switching irradiances. In addition, waveguide geometries will lead to further reductions in the switching energy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Improvement of Field-Emission Characteristics of Carbon Nanotubes by Post Electrical Treatment (2007)

The field-emission characteristics of carbon nanotubes (CNTs), such as uniformity and brightness, were improved by electrical treatment using nonstationary electric fields between the cathode of screen-printed CNT emitters and the anode of a phosphor-coated indium-tin-oxide glass substrate in diode configuration. Dead or weak emission spots, where almost no emission of electrons was observed, started to emit electrons by applying an alternating-current voltage to the cathode electrode and a constant voltage to the anode electrode. The nonstationary electrical treatment was more effective than the direct-current (dc) and the square-pulsed electrical treatments for the emission uniformity and brightness. It was found that the nonstationary electrical treatment not only activated CNT emitters but also suppressed abnormally high emission spots without the drawbacks of electrical breakdown. Consequently, more than 1.8 and 1.3 times improvements of emission uniformity and brightness, respectively, were obtained after the treatment, when compared with the dc electrical treatment for the same amount of emission currents and the same duration of the treatments. Therefore, the method can be effectively applied to field-emission devices based on CNTs for the enhancement of emission properties.
FastDepth: Fast Monocular Depth Estimation on Embedded Systems (2019)

Depth sensing is a critical function for robotic tasks such as localization, mapping and obstacle detection. There has been a significant and growing interest in depth estimation from a single RGB image, due to the relatively low cost and size of monocular cameras. However, state-of-the-art single-view depth estimation algorithms are based on fairly complex deep neural networks that are too slow for real-time inference on an embedded platform, for instance, mounted on a micro aerial vehicle. In this paper, we address the problem of fast depth estimation on embedded systems. We propose an efficient and lightweight encoder-decoder network architecture and apply network pruning to further reduce computational complexity and latency. In particular, we focus on the design of a low-latency decoder. Our methodology demonstrates that it is possible to achieve similar accuracy as prior work on depth estimation, but at inference speeds that are an order of magnitude faster. Our proposed network, FastDepth, runs at 178 fps on an NVIDIA Jetson TX2 GPU and at 27 fps when using only the TX2 CPU, with active power consumption under 10 W. FastDepth achieves close to state-of-the-art accuracy on the NYU Depth v2 dataset. To the best of the authors' knowledge, this paper demonstrates real-time monocular depth estimation using a deep neural network with the lowest latency and highest throughput on an embedded platform that can be carried by a micro aerial vehicle.
Composite TTS voices. (2010)

A new approach to synthetic voice generation and modification is described. One aspect of the approach is that no attempt is made to parametrize voices, unlike the commonly used Gaussian Mixture Model (GMM) paradigm and the newer eigenvoice techniques. Instead, a straightforward unit selection approach is adopted. A second aspect is that we systematically examine mixing units from different voices in a unit selection context. We present experimental results to show the effect of different voice mixing strategies. The modified voices we produce are high quality but do not have the full range of possibilities achievable using voice conversion. Perceptual evaluations of voice similarity and paired comparison preference judgments of the synthetic voices were used to examine the importance of several features or classes of phones to perceived speaker identity. Index Terms: voice conversion, speech synthesis, unit selection, voice similarity, speaker identity
Effect of aging on 6-keto-PGF1.ALPHA. levels in normotensive and essential hypertensive males. (1983)

Prostacyclin (PGI2) is produced in the vessel wall and acts as a vasodilator hormone. Measurement of plasma 6-keto-PGF1 alpha is considered to be an index of PGI2 production. In the present study the effects of aging on the plasma 6-keto-PGF1 alpha levels were studied in 64 normotensive and 48 essential hypertensive males. The subjects were divided into 3 groups, i.e., young (24-39 years), middle-aged (40-55 years) and elderly (over 56 years) groups. Plasma 6-keto-PGF1 alpha was measured by specific radioimmunoassay after silicic acid column chromatographic purification. The 6-keto-PGF1 alpha levels were lower in elderly normotensive males (10.3 +/- 1.4 pg/ml, mean +/- SE, n = 12) than in normotensive young males (15.3 +/- 2.3, n = 30, p less than 0.05). The plasma 6-keto-PGF1 alpha levels in hypertensive elderly males (10.6 +/- 1.3 pg/ml, n = 10) is lower than in hypertensive young males (19.8 +/- 2.2, n = 17, p less than 0.01). These results indicate that the plasma 6-keto-PGF1 alpha levels decreased with age in both normotensive and hypertensive groups. Thus, PGI2 production may decrease with age.
Effective Targeting of Leukemic Cells in Children with B-Precursor Acute Lymphoblastic Leukemia Treated with Anti-CD22 (Epratuzumab). A Children’s Oncology Group (COG) Study. (2006)

Abstract Identifying new approaches to treating relapsed ALL is a top priority because these patients fare poorly with current retrieval strategies. COG protocol ADVL04P2 is a phase I/II feasibility pilot study for children with relapsed B-precursor ALL that uses epratuzumab, a humanized anti-CD22 monoclonal antibody, in combination with conventional re-induction chemotherapy. Children whose blasts are CD22 positive first receive 4 doses of 360 mg/m2 epratuzumab as a single agent on days minus(−)14, −10, −6 and −2. Subsequently, they receive epratuzumab weekly in combination with standard re-induction chemotherapy starting on day 0. We assessed the effectiveness of epratuzumab targeting by by assaying CD22 expression on residual leukemic blasts. Peripheral blood was obtained from 15 patients 24 hours after administration of the first dose (day −13), and again at day −6 and day 0 and stained with the combination of CD10/CD22/CD45/CD19 in four color flow cytometry to permit assessment of CD22 on analytically isolated leukemic blasts. We determined quantitative expression of CD22 with a calibration kit (Quantibrite, BDBiosciences, San Jose, CA) using two PE-conjugated anti CD22 antibodies directed against different epitopes of the CD22 molecule: clone RFB4 (Caltag, Burlingame CA), directed against the same epitope as epratuzumab, and clone SHCL-1 (BDBiosciences), directed against a non-cross-reacting epitope of CD22. RFB4 binding was decreased by more than 99% within 24 hours after administration of the first dose in all patients, indicating rapid targeting of epratuzumab to leukemic cells. In all but 4 patients, levels remained low at all subsequent time points; in 2 patients expression was restored to about 15% of baseline levels by day 0, and 2 additional patients had very small (1–2%) subsets of blasts with significant expression, one at day −6 and one at day 0. In contrast to RFB4, SHCL-1 identified residual CD22 antigen expression, but SHCL-1 binding was decreased by an average of 70–75% in 14 of 15 patients at all three post-epratuzumab timepoints. The one patient with no change in SHCL-1 binding was a patient with MLL-rearranged ALL with very low levels of CD22 expression at diagnosis, and poor response to therapy. Because binding of epratuzumab to CD22 has been shown to result in antigen internalization in vitro, we interpret our findings as demonstrating in vivo internalization of CD22 with epratuzumab binding, though we cannot exclude either shedding of antigen or conformational change to block SHCL-1 sites. We conclude that epratuzumab rapidly targets CD22 on ALL blasts in vivo, though some blasts in some patients may escape over time. Targeting is associated with a physical change in CD22 antigen expression in most patients, most likely through internalization.
PROTEIN-CODING AND MICRORNA BIOMARKER GENE PANELS PREDICTIVE OF CLINICAL RECURRENCE IN PROSTATE CANCER (2009)

You have accessJournal of Urology1 Apr 2009PROTEIN-CODING AND MICRORNA BIOMARKER GENE PANELS PREDICTIVE OF CLINICAL RECURRENCE IN PROSTATE CANCER John A Petros, Yu-Heng Lai, Arun Seth, Adeboye O Osunkoya, Wei Zhou, Brent A Johnson, Robert Nam, Benjamin Barwick, Mark Abramovitz, Mark Bouzyk, Brian Leyland-Jones, and Carlos S Moreno John A PetrosJohn A Petros More articles by this author , Yu-Heng LaiYu-Heng Lai More articles by this author , Arun SethArun Seth More articles by this author , Adeboye O OsunkoyaAdeboye O Osunkoya More articles by this author , Wei ZhouWei Zhou More articles by this author , Brent A JohnsonBrent A Johnson More articles by this author , Robert NamRobert Nam More articles by this author , Benjamin BarwickBenjamin Barwick More articles by this author , Mark AbramovitzMark Abramovitz More articles by this author , Mark BouzykMark Bouzyk More articles by this author , Brian Leyland-JonesBrian Leyland-Jones More articles by this author , and Carlos S MorenoCarlos S Moreno More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)62162-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "PROTEIN-CODING AND MICRORNA BIOMARKER GENE PANELS PREDICTIVE OF CLINICAL RECURRENCE IN PROSTATE CANCER." The Journal of Urology, 181(4S), p. 776 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 776 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information John A Petros More articles by this author Yu-Heng Lai More articles by this author Arun Seth More articles by this author Adeboye O Osunkoya More articles by this author Wei Zhou More articles by this author Brent A Johnson More articles by this author Robert Nam More articles by this author Benjamin Barwick More articles by this author Mark Abramovitz More articles by this author Mark Bouzyk More articles by this author Brian Leyland-Jones More articles by this author Carlos S Moreno More articles by this author Expand All Advertisement PDF downloadLoading ...
KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines (2015)

KRAS is one of the most frequently mutated oncogenes in human cancer, yet remaining undruggable. To explore a new therapeutic strategy, a library of 5-methyl-indolo[3,2-c]quinoline derivatives (IQc) with a range of alkyldiamine side chains was designed to target DNA and RNA G-quadruplexes (G4) in the promoter and 5'-UTR mRNA of the KRAS gene. Biophysical experiments showed that di-substituted IQc compounds are potent and selective KRAS G4 stabilizers. They preferentially inhibit the proliferation of KRAS mutant cancer cell lines (0.22 < IC50 < 4.80 μM), down-regulate KRAS promoter activity in a luciferase reporter assay, and reduce both KRAS mRNA and p21(KRAS) steady-state levels in mutant KRAS colon cancer cell lines. Additionally, IQcs induce cancer cell death by apoptosis, explained in part by their capacity to repress KRAS expression. Overall, the results suggest that targeting mutant KRAS at the gene level with G4 binding small molecules is a promising anticancer strategy.
Mirror based fusion neutron source: Current status and prospective (2016)

The paper presents a recent progress in experimental studies and status of numerical simulations of the mirror based fusion neutron source developed by the Budker Institute of Nuclear Physics (Novosibirsk, Russia) and its possible applications including a fusion material test facility and a fusion-fission hybrid system. Current research activity is supported by the Russian Science Foundation (project N 14-50-00080).
Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E (2020)

The findings in this study identify new mechanisms by which circulating HDL, particularly HDL particles enriched in apoE, may provide vascular resilience to Aβ and shed new light on a potential role of peripherally-acting apoE in AD.
<title>Design and analysis of a depolarizer for the NASA MODerate-resolution Imaging Spectrometer-Tilt (MODIS-T)</title> (1992)

The design and analysis of a depolarizer for the NASA MODIS-T spectrometer is presented. The theory of spatial pseudodepolarizer operation and its effect on linear polarization sensitivity is described. Details of the HV depolarizer design and issues of depolarizer location and material are discussed. The image doubling and aberrations induced by the depolarizer and the trade-offs between increased polarization performance and decreased image quality are also addressed. The issues considered apply directly to depolarizer design for other remote sensing instruments.
Determinants of cortical gray matter volume: hypothesis based on developmental cohorts with normal and abnormal cortical morphology (2006)

Normal course of cortical maturation has been evidenced for many years through gray matter volume measurements and abnormal gray matter volumes have frequently been reported as a part of a pathological brain development in neurogenetic or psychiatric disorders. The pathogenic processes underlying abnormal gray matter volume are not yet well understood, as either altered cortical thickness or a defect in cortical expansion may decrease cortical volume. Resolving this issue may provide clues for localizing the timing of the alteration. Indeed, expansion of the cortical surface is allowed by both increase in brain perimeter and folding of the cortical sheet (gyrification) during early brain development. Conversely, alteration of cortical thickness may occur at different developmental stage. Here, we aimed to identify the respective contribution of these processes to cortical volume in the parietal lobe, in a cohort of typically developing young individuals compared to patients affected by 22q11 Deletion Syndrome (22q11DS). 22q11DS is a common neurogenetic condition in which parietal gray matter (Eliez, 2000) and gyrification (Schaer, in press) are specifically altered early in development.
Small Conductance Ca2+-Activated K+ Channel Knock-Out Mice Reveal the Identity of Calcium-Dependent Afterhyperpolarization Currents (2004)

Action potentials in many central neurons are followed by a prolonged afterhyperpolarization (AHP) that influences firing frequency and affects neuronal integration. In hippocampal CA1 pyramidal neurons, the current ascribed to the AHP (IAHP) has three kinetic components. The IfastAHP is predominantly attributable to voltage-dependent K+ channels, whereas Ca2+-dependent and voltage-independent K+channels contribute to the ImediumAHP (ImAHP) and IslowAHP (IsAHP). Apamin, which selectively suppresses a component of the mAHP, increases neuronal excitability and facilitates the induction of synaptic plasticity at Schaffer collateral synapses and hippocampal-dependent learning. The Ca2+-dependent components of the AHP have been attributed to the activity of small conductance Ca2+-activated K+ (SK) channels. Examination of transgenic mice, each lacking one of the three SK channel genes expressed in the CNS, reveals that mice without the SK2 subunit completely lack the apamin-sensitive component of the ImAHP in CA1 neurons, whereas the IsAHP is not different in any of the SK transgenic mice. In each of the transgenic lines, the expression levels of the remaining SK genes are not changed. The results demonstrate that only SK2 channels are necessary for the ImAHP, and none of the SK channels underlie the IsAHP.
New macrocycles of carbon, nitrogen and sulfur atoms incorporating 4,5-dithio-1,3-dithiole-2-thione units (1992)

Condensation of 2-thioxo-1, 3-dithiole-4,5-dithiolate dianion, generated in situ from 4,5-bis-(benzoyl-thio)-1,3-dithiole-2-thione, with 4,4′-bis(bromomethyl)-2,2′-bi-1,3-thiol gives a mixture of macrocyclic compounds 3, 4, 5 and 6 while only the symmetrical product 9 was isolated using the 5,5′-bis(ethoxycarbonyl) derivative of the same bithiazole. The use of plasma desorption mass spectroscopy in analysing oligomeric reaction products, where low solubility makes the use of other conventional methods difficult is also reported.
Thermodynamic analysis of humidification dehumidification desalination cycles (2009)

Humidification–dehumidification desalination (HDH) is a promising technology for small-scale water production applications. There are several embodiments of this technology which have been investigated by researchers around the world. However, from a previous literature [1], we have found that no study carried out a detailed thermodynamic analysis in order to improve and/ or optimize the system performance. In this paper, we analyze the thermodynamic performance of various HDH cycles by way of a theoretical cycle analysis. In addition, we propose novel high performance variations on those cycles. These high-performance cycles include multi-extraction, multi-pressure and thermal vapor compression cycles. It is predicted that the systems based on these novel cycles will have gained output ratio in excess of 5 and will outperform existing HDH systems.
A vector space approach to adaptive beamforming (2003)

A novel vector space approach for adaptive beamforming is presented. The vector space method is formulated for both narrowband and broadband arrays. It consists of first formulating the beamforming problem as a linear system of equations in a matrix-vector form and then finding the solution to the system with an iterative matrix inversion technique known as the row-action projection algorithm. The vector space approach for narrowband and broadband arrays is compared to the more well-known algorithms via computer simulations. The row-action projection algorithm demonstrates performance comparable to that of the well-known algorithms while providing potential advantages for parallel implementations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Photoinduced gliding of the surface director in azo‐dye doped nematic liquid crystals (2008)

We report photoinduced surface director gliding with azo dye‐doped nematic liquid crystals. This gliding has the same characteristics as that induced by an applied magnetic field. Fast and slow dynamic regimes are observed, the latter fitting to a stretched exponential. In addition, the gliding demonstrates a ‘sensitizing’ effect for sequential measurements.
Parallel Grid Pooling for Data Augmentation (2018)

Convolutional neural network (CNN) architectures utilize downsampling layers, which restrict the subsequent layers to learn spatially invariant features while reducing computational costs. However, such a downsampling operation makes it impossible to use the full spectrum of input features. Motivated by this observation, we propose a novel layer called parallel grid pooling (PGP) which is applicable to various CNN models. PGP performs downsampling without discarding any intermediate feature. It works as data augmentation and is complementary to commonly used data augmentation techniques. Furthermore, we demonstrate that a dilated convolution can naturally be represented using PGP operations, which suggests that the dilated convolution can also be regarded as a type of data augmentation technique. Experimental results based on popular image classification benchmarks demonstrate the effectiveness of the proposed method. Code is available at: https://github.com/akitotakeki
Oxygen Degradation in Mesoporous Al2O3/CH3NH3PbI3‐xClx Perovskite Solar Cells: Kinetics and Mechanisms (2016)

The rapid pace of development for hybrid perovskite photovoltaics has recently resulted in promising figures of merit being obtained with regard to device stability. Rather than relying upon expensive barrier materials, realizing market‐competitive lifetimes is likely to require the development of intrinsically stable devices, and to this end accelerated aging tests can help identify degradation mechanisms that arise over the long term. Here, oxygen‐induced degradation of archetypal perovskite solar cells under operation is observed, even in dry conditions. With prolonged aging, this process ultimately drives decomposition of the perovskite. It is deduced that this is related to charge build‐up in the perovskite layer, and it is shown that by efficiently extracting charge this degradation can be mitigated. The results confirm the importance of high charge‐extraction efficiency in maximizing the tolerance of perovskite solar cells to oxygen.
Speed versus Accuracy Trade-Offs in Microarchitectural Simulations (2007)

Due to the long simulation time of the reference input set, computer architects often use reduced time simulation techniques to shorten the simulation time. However, what has not yet been thoroughly evaluated is the accuracy of these techniques relative to the reference input set and with respect to each other. To rectify this deficiency, this paper uses three methods to characterize reduced input set, truncated execution, and sampling-based simulation techniques while also examining their speed versus accuracy trade-off and configuration dependence. Our results show that the three sampling-based techniques, SimPoint, SMARTS, and random sampling, have the best accuracy, the best speed versus accuracy trade-off, and the least configuration dependence. On the other hand, the reduced input set and truncated execution simulation techniques had generally poor accuracy, were not significantly faster than the sampling-based techniques, and were severely configuration dependent. The final contribution of this paper is a decision tree, which can help architects choose the most appropriate technique for their simulations.