gebhart/patrepeval huggingface dataset:
Wearable Surface‐Lighting Micro‐Light‐Emitting Diode Patch for Melanogenesis Inhibition (2022)

Abstract Wearable light‐emitting diode (LED)‐based phototherapeutic devices have recently attracted attention as skin care tools for wrinkles, acne, and hyperpigmentation. However, the therapeutic effectiveness and safety of LED stimulators are still controversial due to their inefficient light transfer, high heat generation, and non‐uniform spot irradiation. Here, a wearable surface‐lighting micro‐LED (SµLED) photostimulator is reported for skin care and cosmetic applications. The SµLEDs, consisting of a light diffusion layer (LDL), 900 thin film µLEDs, and polydimethylsiloxane (PDMS), achieve uniform surface‐lighting in 2 × 2 cm 2 ‐sized area with 100% emission yields. The SµLEDs maximize photostimulation effectiveness on the skin surface by uniform irradiation, high flexibility, and thermal stability. The SµLED's effect on melanogenesis inhibition is evaluated via in vitro and in vivo experiments to human skin equivalents (HSEs) and mouse dorsal skin, respectively. The anti‐melanogenic effect of SµLEDs is confirmed by significantly reduced levels of melanin contents, melan‐A, tyrosinase, and microphthalmia‐associated transcription factor (MITF), compared to a conventional LED (CLED) stimulator.
vCorfu: a cloud-scale object store on a shared log (2017)

This paper presents vCorfu, a strongly consistent cloudscale object store built over a shared log. vCorfu augments the traditional replication scheme of a shared log to provide fast reads and leverages a new technique, composable state machine replication, to compose large state machines from smaller ones, enabling the use of state machine replication to be used to efficiently in huge data stores. We show that vCorfu outperforms Cassandra, a popular state-of-the art NOSQL stores while providing strong consistency (opacity, read-own-writes), efficient transactions, and global snapshots at cloud scale.
Interleukin 2‐dependent activation of tumor‐specific cytotoxic T lymphocytes in vivo (1991)

We have quantitatively studied the effect of interleukin (IL) 2 on the cytotoxic T lymphocyte (CTL) response to tumor cells in vivo. Mastocytoma P815 was transfected with murine IL 2 cDNA (P815-IL 2) and injected into syngeneic mice. The anti-tumor response was analyzed and compared with the response induced by the non-transfected cells. P815 parental cells are highly tumorigenic, causing death within 20-30 days. In contrast, IL 2-transfected cells were totally rejected. Co-injection of IL 2-secreting and parental cells resulted in the inhibition of growth of both type of tumors. In addition, the response induced by IL 2-secreting cells protected the mice against a subsequent challenge with P815. Long-term memory persisted in treated mice 3 months after tumor rejection. Frequencies of CTL precursors and CTL specific for P815 increased as a result of IL 2 secretion by the target cells. Estimates of CTL frequency at days 8 and 12 after injection were 2 to 3 times higher in mice inoculated with P815-IL 2 cells, and this correlated with tumor rejection.
Sex-Specific Crossover Distributions and Variations in Interference Level along Arabidopsis thaliana Chromosome 4 (2007)

In many species, sex-related differences in crossover (CO) rates have been described at chromosomal and regional levels. In this study, we determined the CO distribution along the entire Arabidopsis thaliana Chromosome 4 (18 Mb) in male and female meiosis, using high density genetic maps built on large backcross populations (44 markers, >1,300 plants). We observed dramatic differences between male and female map lengths that were calculated as 88 cM and 52 cM, respectively. This difference is remarkably parallel to that between the total synaptonemal complex lengths measured in male and female meiocytes by immunolabeling of ZYP1 (a component of the synaptonemal complex). Moreover, CO landscapes were clearly different: in particular, at both ends of the map, male CO rates were higher (up to 4-fold the mean value), whereas female CO rates were equal or even below the chromosomal average. This unique material gave us the opportunity to perform a detailed analysis of CO interference on Chromosome 4 in male and female meiosis. The number of COs per chromosome and the distances between them clearly departs from randomness. Strikingly, the interference level (measured by coincidence) varied significantly along the chromosome in male meiosis and was correlated to the physical distance between COs. The significance of this finding on the relevance of current CO interference models is discussed.
Design and fabrication of ultra-low crosstalk and low-loss multi-core fiber: erratum (2019)

This erratum amends typographical errors in Eq. (1) and Table 2Table 2Optical properties of each core of the fabricated MCF.Attenuation [dB/km]MFD [µm]Aeff [µm2]λcc [nm]CD [ps/nm/km]D. Slope [ps/nm2/km]Bend loss (R = 5 mm) [dB/turn]PMD [ps/√km]λ [nm]1550162515501550N/A1550155015501625C + LDesignN/AN/A9.8679.6149623.30.0630.0100.021N/ACore 10.1760.1969.8380.2150922.20.0620.0110.0200.132Core 20.1790.1979.7680.2150022.20.0620.0100.0200.134Core 30.1810.2029.8881.3150422.20.0620.0100.0200.044Core 40.1770.1999.8580.8149822.20.0620.0110.0210.093Core 50.1750.1929.7479.0148522.20.0620.0110.0220.205Core 60.1790.2009.8079.9148322.10.0620.0110.0220.116Core 70.1770.1979.7278.2149822.20.0620.0100.0190.106 in Opt. Express 19, 16576 (2011).
A Novel Liposome-Based Adjuvant CAF01 for Induction of CD8+ Cytotoxic T-Lymphocytes (CTL) to HIV-1 Minimal CTL Peptides in HLA-A*0201 Transgenic Mice (2009)

We found that CAF01 induced cellular immune responses against HIV-1 minimal CTL epitopes in HLA-A*0201 transgenic mice to levels comparable with that of incomplete Freund's adjuvant.
A low cost test vehicle for embedded DRAM capacitor: Investigation and monitoring of the process (2004)

A test vehicle for embedded DRAM capacitor is developed with a low cost approach. This test vehicle allows us to get planar DRAM capacitors for process investigation and monitoring. The test vehicle capacitor gives electrical characteristics similar to the capacitor of the product test structure. A Design Of Experiment (DOE) has been performed to get a process window of the DRAM capacitor. For the first time, we show that in-line AFM is a monitoring tool for Hemispherical Silicon Grain (HSG) deposition. We show that the leakage of the DRAM capacitor is linked to its intrinsic reliability.
Gene therapy for alpha 1-antitrypsin deficiency with an oxidant-resistant human alpha 1-antitrypsin (2020)

Alpha 1-antitrypsin (AAT) deficiency, a hereditary disorder characterized by low serum levels of functional AAT, is associated with early development of panacinar emphysema. AAT inhibits serine proteases, including neutrophil elastase, protecting the lung from proteolytic destruction. Cigarette smoke, pollution, and inflammatory cell-mediated oxidation of methionine (M) 351 and 358 inactivates AAT, limiting lung protection. In vitro studies using amino acid substitutions demonstrated that replacing M351 with valine (V) and M358 with leucine (L) on a normal M1 alanine (A) 213 background provided maximum antiprotease protection despite oxidant stress. We hypothesized that a onetime administration of a serotype 8 adeno-associated virus (AAV8) gene transfer vector coding for the oxidation-resistant variant AAT (A213/V351/L358; 8/AVL) would maintain antiprotease activity under oxidant stress compared with normal AAT (A213/M351/M358; 8/AMM). 8/AVL was administered via intravenous (IV) and intrapleural (IPL) routes to C57BL/6 mice. High, dose-dependent AAT levels were found in the serum and lung epithelial lining fluid (ELF) of mice administered 8/AVL or 8/AMM by IV or IPL. 8/AVL serum and ELF retained serine protease-inhibitory activity despite oxidant stress while 8/AMM function was abolished. 8/AVL represents a second-generation gene therapy for AAT deficiency providing effective antiprotease protection even with oxidant stress.
Planar Ego-Motion Without Correspondences (2005)

General structure-from-motion methods are not adept at dealing with constrained camera motions, even though such motions greatly simplify vision tasks like mobile robot localization. Typical ego-motion techniques designed for such a purpose require locating feature correspondences between images. However, there are many cases where features cannot be matched robustly. For example, images from panoramic sensors are limited by nonuniform angular sampling, which can complicate the feature matching process under wide baseline motions. In this paper we compute the planar ego-motion of a spherical sensor without correspondences. We propose a generalized Hough transform on the space of planar motions. Our transform directly processes the information contained within all the possible feature pair combinations between two images, thereby circumventing the need to isolate the best corresponding matches. We generate the Hough space in an efficient manner by studying the spectral information contained in images of the feature pairs, and by re-treating our Hough transform as a correlation of such feature pair images.
Annotation of chitin biosynthesis genes in Diaphorina citri, the Asian citrus psyllid (2021)

The polysaccharide chitin is critical for the formation of many insect structures, including the exoskeleton, and is required for normal development. Here we report the annotation of three genes from the chitin synthesis pathway in the Asian citrus psyllid, <i>Diaphorina citri</i> (Hemiptera: Liviidae), the vector of Huanglongbing (citrus greening disease). Most insects have two chitin synthase (CHS) genes but, like other hemipterans, <i>D. citri</i> has only one. In contrast, <i>D. citri</i> is unusual among insects in having two UDP-N-acetylglucosamine pyrophosphorylase (UAP) genes. One of the <i>D. citri</i> UAP genes is broadly expressed, while the other is expressed predominantly in males. Our work helps pave the way for potential utilization of these genes as pest control targets to reduce the spread of Huanglongbing.
812: Androgen and HSP27 Cooperatively Interact to Facilitate Genomic and Non-Genomic Activity of the Androgen Receptor to Enhance Prostate Cancer Survival (2006)

You have accessJournal of UrologyDiscussed Poster, Monday, May 22, 2006, 1:00 - 4:00 pm1 Apr 2006812: Androgen and HSP27 Cooperatively Interact to Facilitate Genomic and Non-Genomic Activity of the Androgen Receptor to Enhance Prostate Cancer Survival Amina Zoubeidi, Shannon Sinnemann, and Martin E. Gleave Amina ZoubeidiAmina Zoubeidi More articles by this author , Shannon SinnemannShannon Sinnemann More articles by this author , and Martin E. GleaveMartin E. Gleave More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33048-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "812: Androgen and HSP27 Cooperatively Interact to Facilitate Genomic and Non-Genomic Activity of the Androgen Receptor to Enhance Prostate Cancer Survival." The Journal of Urology, 175(4S), p. 262 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 262 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Amina Zoubeidi More articles by this author Shannon Sinnemann More articles by this author Martin E. Gleave More articles by this author Expand All Advertisement PDF downloadLoading ...
Fabrication and characterization of a self-aligned gate stack for electronics applications (2021)

A metal–oxide–semiconductor (MOS) gate stack that is self-aligned with the underlying silicon doping profile is demonstrated. We combine a new hybrid bottom-up patterning technique with atomic layer deposition (ALD) to selectively deposit a platinum-hafnium dioxide-silicon MOS gate stack. A poly(methyl methacrylate) (PMMA) brush is blanket grown from a Si(100) surface and selectively removed from the lightly doped (∼1018 cm−3) regions using a doping-selective KOH etch. The PMMA brush that remains on the heavily doped (∼1020 cm−3) regions effectively blocks the ALD of both HfO2 and platinum. MOS capacitors exhibit promising capacitance-voltage characteristics with a HfO2 dielectric constant of ∼25 and an average interface state density of 2.1 × 1011 eV−1 cm−2 following forming gas anneal.
Functional near-infrared spectroscopy in non-domesticated grey seals (2021)

Functional near-infrared spectroscopy is successfully used to measure brain activation to visual, auditory, and tactile stimuli in non-domesticated grey seals. The results encourage further investigation of cognition in free-ranging animals.
Supplementary Movie 4 from Tivantinib (ARQ 197) Exhibits Antitumor Activity by Directly Interacting with Tubulin and Overcomes ABC Transporter–Mediated Drug Resistance (2023)

&lt;p&gt;Control (SK-MEL-28 Fucci).&lt;/p&gt;
Vertically scaled 5 nm GaN channel enhancement-mode N-polar GaN MOS-HFET with 560 mS/mm g<sub>m</sub> and 0.76 &#x003A9;-mm R<sub>on</sub> (2011)

This paper reports a self-aligned N-polar GaN FET with a 5-nm GaN channel and atomic layer deposited (ALD) Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> gate dielectric with a peak I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> of 1.2 A/mm and peak gm of 560 mS/mm. The R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> of 0.76 Ω-mm for this device is the lowest reported for E-mode GaN FETs.
ChemInform Abstract: Activation of H2 by Chlorocarbonylbis(trimethylphosphine)rhodium(I) Labilizes CO and Produces the New Binuclear Complex H(Cl)Rh(PMe3)2(μ‐H)(μ‐Cl)Rh(PMe3)(CO). (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Contrast Inversion in TEM Studies of Poly(ferrocenylsilane)‐block‐Poly(dimethylsiloxane) Diblock Copolymers (2008)

Abstract This paper describes an unusual contrast inversion phenomenon in TEM imaging of PFS‐ b ‐PDMS block copolymer bulk samples. It is clearly observed especially in samples that show a lamellar morphology that the contrast inversion is accompanied by a contraction of the PDMS domains and an expansion of the Fe‐rich domains. The location of the iron‐ and silicon‐rich domains was monitored by EDX analysis. We infer that the contrast inversion was caused by electron beam radiation‐induced damage to, and possible cross‐linking of, PDMS chains. A simple way to selectively deposit metal on electron beam patterned polymer film was demonstrated. magnified image
Physioxia improves the selectivity of hematopoietic stem cell expansion cultures (2023)

Hematopoietic stem cells (HSCs) are a rare type of hematopoietic cell that can entirely reconstitute the blood and immune system after transplantation. Allogeneic HSC transplantation (HSCT) is used clinically as a curative therapy for a range of hematolymphoid diseases; however, it remains a high-risk therapy because of its potential side effects, including poor graft function and graft-versus-host disease (GVHD). Ex vivo HSC expansion has been suggested as an approach to improve hematopoietic reconstitution in low-cell dose grafts. Here, we demonstrate that the selectivity of polyvinyl alcohol (PVA)-based mouse HSC cultures can be improved using physioxic culture conditions. Single-cell transcriptomic analysis helped confirm the inhibition of lineage-committed progenitor cells in physioxic cultures. Long-term physioxic expansion also afforded culture-based ex vivo HSC selection from whole bone marrow, spleen, and embryonic tissues. Furthermore, we provide evidence that HSC-selective ex vivo cultures deplete GVHD-causing T cells and that this approach can be combined with genotoxic-free antibody-based conditioning HSCT approaches. Our results offer a simple approach to improve PVA-based HSC cultures and the underlying molecular phenotype, and highlight the potential translational implications of selective HSC expansion systems for allogeneic HSCT.
Slow Nonradiative Decay for Rare Earths in KPb2Br5 and RbPb2Br5 (2004)

We report on spectroscopic investigations of Nd3+- and Tb3+- doped low phonon energy, moisture-resistant host crystals, KPb2Br5 and RbPb2Br5, and their potential to serve as new solid state laser materials at new wavelengths, especially in the long wavelength infrared region. This includes emission spectra, emission lifetime measurements, Raman scattering spectra as well as calculations of the multiphonon decay rate, radiative lifetimes and quantum efficiencies for relevant (laser) transitions in these crystals.
A co-channel interference cancellation technique using orthogonal convolutional codes on multipath Rayleigh fading channel (1997)

This paper proposes and evaluates a new co-channel interference cancellation technique that utilizes orthogonal convolutional codes on a multipath Raleigh fading channel. In a spread spectrum multiple access environment co-channel interference (CCI) limits the performance of the communication link. To remove this interference, several CCI cancellation techniques have been proposed, including a technique that does not require the receiver to have knowledge of the cross-correlation between user sequences. This method leaves residual interference after the cancellation caused by errors in the initial decisions. To reduce the residual interference and improve the initial decisions, the proposed scheme utilizes the error-correcting capability of orthogonal convolutional codes. This paper evaluates the performance of this scheme. Our results show that the proposed CCI canceller offers an improvement in capacity of a factor of 1.5/spl sim/3 as compared with a conventional canceller on a multipath Rayleigh fading channel. The proposed canceller works in the presence of residual interference due to imperfect cancellation. The proposed canceller also has a capacity improvement with the use of soft handoff in a multicell configuration.
Automating Mashups for Next-Generation Enterprise Portals (2009)

The increasing number of resources available through portals establish a need to tailor information to individual needs and situations. Mashups are tools for dynamically integrating independent applications. For portals, what is needed are means to automatically create personalized mashups that optimally fit a user's information needs in a given situation. At the core of our approach are different ontology-based models that describe the user, the domain, possible information needs in this domain, and personalization rules determining which information to present to which user in which situation.
An analysis of electrical equivalent circuit constants for a GT cut quartz crystal resonator with supporting portions at both ends (1989)

Abstract A GT cut quartz crystal resonator with supporting portions at both ends has superior frequency‐temperature characteristics similar to the conventional rectangular GT plate. It was reported that it is a high‐ Q resonator with a small equivalent series resistance from experiments [1, 2]. In this paper, the electrical equivalent circuit constants of the GT cut quartz crystal resonator with supporting portions at both ends is described. First, the equivalent circuit of the GT cut quartz crystal resonator is studied. It is found that the main vibration and the subvibration can be treated approximately as a single‐mode resonator since the coupling coefficient is only about 3 percent. Next, the relationship of the motional inductance L 1 , motional capacitance C 1 , parallel capacitance C O , capacitance ratio r 1 , and electromechanical coupling coefficient K vl of the main vibration to the plate thickness electrode area and cut angle ϕ is found theoretically. Also found is the relationship of the motional inductance L 2 of the subvibration and the plate thickness. These relationships are compared with the experiments. Calculated and measured results agreed well. Hence, the present analytical results are useful for design of a resonator with a new frequency.
Supplemental Figure 4 from An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2 (2023)

&lt;p&gt;Supplemental Figure 4. DNA repair score trends higher in TTF1-low LUAD cell lines.&lt;/p&gt;
Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications (2017)

Negative allosteric modulators (NAM) of metabotropic glutamate receptor 5 (mGluR5) have been implicated as a potential pharmacotherapy for a number of psychiatric diseases, including anxiety and depression. Most of the mGluR5 NAM clinical candidates can be characterized by the central acetylenic moiety that connects the terminal pharmacophores. Identification of a sulfoquinoline hit via high throughput screening (HTS) followed by optimization provided a 4-phenyl-3-aryl-sulfoquinoline lead compound with the minimal pharmacophore. Optimization of the core and aryl appendages was performed by scanning and matrix libraries synthesized by the multiple parallel synthesis approach. Biological evaluation of matrix libraries provided a number of potent, metabolically stable, and in vivo active compounds. One of these compounds, 25 showed high efficacy and safety in preclinical in vivo models; this allowed its nomination as a novel, nonacetylenic mGluR5 NAM clinical candidate. Compound 25 was advanced to first-in-man trials for the treatment of psychiatric conditions.
Average arrival time of wave pulses through continuous random media (1985)

It is pointed out that a continuous random medium can cause an average advance of the arrival time of a pulse. This advance will occur for unsaturated and partially saturated propagation, but not in full saturation (which corresponds to the discrete scatterer case). The effect, which is associated with Fermat's principle of least time, can be observed by measuring the difference between intensity-weighted and unweighted average arrival times.
Characterization of Polystyrenes (1 kDa) Functionalized With and Without a Perfluorinated Endgroup by TOF-SIMS: Observation of Intact Oligomers and Endgroup Effects (1996)

TOF-SIMS measurements of 1 kDa polystyrene functionalized with a perfluoroalkyl endgroup are presented. Intact oligomer signals in the high mass range and fragment signals in the low mass range are observed (monolayer sample preparation on a silver substrate). The successful functionalization of the polystyrene with the perfluoroalkyl endgroup can be confirmed by the masses at which the intact oligomer signals arise. The high mass region of the spectrum is compared to TOF-SIMS measurements of polystyrene with a proton endgroup. The signal for a polystyrene oligomer with a proton endgroup with a specific degree of polymerization (n) arises at a lower mass because of the absence of the perfluoroalkyl endgroup. The effect of endgroup on the ion transformation probability of intact oligomers is demonstrated in a TOF-SIMS spectrum of a physical mixture (1:1 mole ratio) of polystyrene with a proton endgroup and polystyrene with a perfluoroalkyl endgroup.