gebhart/patrepeval huggingface dataset:
A Stul polymorphism on chromosome 3p14.1 -14.2 (D3S622) defined by two polymorphic Stul sites 2.4 kb apart (1991)

Journal Article A Stul polymorphism on chromosome 3p14.1 -14.2 (D3S622) defined by two polymorphic Stul sites 2.4 kb apart Get access S.L. Secore, S.L. Secore Search for other works by this author on: Oxford Academic PubMed Google Scholar A.P. Walker, A.P. Walker Search for other works by this author on: Oxford Academic PubMed Google Scholar M.H. Herbstreith, M.H. Herbstreith Search for other works by this author on: Oxford Academic PubMed Google Scholar T. Siddique, T. Siddique Search for other works by this author on: Oxford Academic PubMed Google Scholar A.J. Jeffers, A.J. Jeffers Search for other works by this author on: Oxford Academic PubMed Google Scholar T.R. DeShields, T.R. DeShields Search for other works by this author on: Oxford Academic PubMed Google Scholar H.C. Speer, H.C. Speer Search for other works by this author on: Oxford Academic PubMed Google Scholar M.A. Pericak-Vance, M.A. Pericak-Vance Search for other works by this author on: Oxford Academic PubMed Google Scholar W.A. Golembieski, W.A. Golembieski 1Wayne State University DetroitMl, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar D.I. Smith, D.I. Smith 1Wayne State University DetroitMl, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more W.Y. Hung, W.Y. Hung Search for other works by this author on: Oxford Academic PubMed Google Scholar L.H. Yamaoka, L.H. Yamaoka Search for other works by this author on: Oxford Academic PubMed Google Scholar A.D. Roses, A.D. Roses Search for other works by this author on: Oxford Academic PubMed Google Scholar R.J. Bartlett R.J. Bartlett Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 22, 25 November 1991, Page 6349, https://doi.org/10.1093/nar/19.22.6349 Published: 25 November 1991
Diastereomer Assignment of an Olefin-Linked Bis-paracyclophane by Ion Mobility Mass Spectrometry (2004)

trans-1,2-Bis([2.2]paracyclophanyl)ethene (1) exists as a pair of diastereomers whose conformations, and thus effective collision cross sections, are quite different. The two forms can be obtained by different transition metal-catalyzed reactions. To assign meso and racemic structures, a novel method is reported in which experimental gas-phase ion mobility data are compared with theoretical structures obtained from molecular mechanics calculations.
The colloid structural forces as a tool for particle characterization and control of dispersion stability (2007)

Knowing the size and interactions of colloid particles, one can predict the stepwise thickness transitions and the contact angles of particle-containing liquid films. Here, we consider the inverse problem, viz. how to determine the particle properties by measurements with liquid films. We carried out experiments with films formed from aqueous solutions of two nonionic surfactants, Brij 35 and Tween 20, which contain spherical micelles of diameters in the range 7-9 nm. From the measured contact angles, we determined the micelle aggregation number and volume fraction. In addition, from the measured disjoining-pressure isotherms we determined the micelle diameter. In other words, the liquid-film measurements give information about the micelles, which is analogous to that obtainable by dynamic and static light scattering. Furthermore, we investigate the predictions of different quantitative criteria for stability-instability transitions, having in mind that the oscillatory forces exhibit both maxima, which play the role of barriers to coagulation, and minima that could produce flocculation or coalescence in colloidal dispersions (emulsions, foams, suspensions). The interplay of the oscillatory force with the van der Waals surface force is taken into account. Two different kinetic criteria are considered, which give similar and physically reasonable results about the stability-instability transitions. Diagrams are constructed, which show the values of the micelle volume fraction, for which the oscillatory barriers can prevent the particles from coming into close contact, or for which a strong flocculation in the depletion minimum or a weak flocculation in the first oscillatory minimum could be observed.
Design and Characterization of a 10 Gb/s Clock and Data Recovery Circuit Implemented with Phase-Locked Loop (1999)

A clock and data recovery circuit with a phase-locked loop for 10 Gb/s optical transmission system was realized in a hybrid IC form. The quadri-correlation architecture is used for frequency- and phase-locked loop. A NRZ-to-PRZ converter and a 360 degree analogue phase shifter are included in the circuit. The jitter characteristics satisfy the recommendations of ITU-T. The capture range of 150 MHz and input voltage sensitivity of 100 mVp-p were showed. The temperature compensation characteristics were tested for the operating temperature from −10 to 60 °C and showed no increase of error. This circuit was adopted for the 10 Gb/s transmission system through a normal single-mode fiber with the length of 400 km and operated successfully.
Latchup-aware placement and parasitic-bounded routing of custom analog cells (1993)

This paper presents new results in constraint-directed placement and routing of device-level analog cells. We describe the first algorithm for latchup-aware device placement that guarantees sufficient placement of well/substrate contacts by simultaneous placement of latchup protection geometry and devices. A novel cost-to-target predictor for cost-based A/sup */ routing, and a new scheme for pruning evolving paths that violate user-supplied constrained routing of analog signals in dense placements are described. Experimental results suggest the strategy avoids the artifacts of length-for-crosstalk trade-offs seen in earlier algorithms, and allows users more fine-grain control of the routing of defense, high-performance cells. An implementation of these ideas in the tool set KA III is used to derive improved layouts from several analog cells.
Simulation of Pulse Discharge of the Li–CF[sub x] System (2007)

A zero-dimensional model is developed for the system to account for Butler–Volmer kinetics, internal cell resistance, and double-layer (or capacitive) charging. At the low rates involved, other transport processes can be neglected. Furthermore, for this system, Tafel kinetics is appropriate. This model is used to compare with discharge data for periodic pulses superposed on an otherwise low rate of discharge. The internal resistance and high double-layer capacity account for some aspects of the pulses, such as a long time relaxation when the load is changed, but do not account for other time constants of less than . For a long constant-load discharge without pulses, the model can be simplified further, with the capacitance being negligible and the internal resistance being important only at low load resistances. Development of a modified open-circuit potential function allows all discharge data for cells of different design and load resistance to be collapsed using a generalized design equation.
Wideband wireless access technologies to broadband internet [Guest Editorial] (2002)

Presents the guest editorial for this issue of the publication.
Critical dislocation speed in helium-4 crystals (2013)

Our experiments show that in ${}^{4}$He crystals, the binding of ${}^{3}$He impurities to dislocations does not necessarily imply their pinning. Indeed, in these crystals, there are two different regimes of the motion of dislocations when impurities bind to them. At low driving strain $\ensuremath{\epsilon}$ and frequency $\ensuremath{\omega}$, where the dislocation speed is less than a critical value (45 $\ensuremath{\mu}$m/s), dislocations and impurities apparently move together. Impurities really pin the dislocations only at higher values of $\ensuremath{\epsilon}\ensuremath{\omega}$. The critical speed separating the two regimes is two orders of magnitude smaller than the average speed of free ${}^{3}$He impurities in the bulk crystal lattice. We obtained this result by studying the dissipation of dislocation motion as a function of the frequency and amplitude of a driving strain applied to a crystal at low temperature. Our results solve an apparent contradiction between some experiments, which showed a frequency-dependent transition temperature from a soft to a stiff state, and other experiments or models where this temperature was assumed to be independent of frequency. The impurity pinning mechanism for dislocations appears to be more complicated than previously assumed.
Broadband rational modeling using Barycentric Vector Fitting (2013)

This paper demonstrates the use of a Barycentric Vector Fitting algorithm for the modeling of broadband frequency responses. This algorithm reduces the computation time of the pole-identification step by exploiting the specific form of the barycentric interpolation formula. Numerical results confirm that this approach can lead to significant savings in terms of computation time, while preserving a good accuracy of the model. The effectiveness of the algorithm is shown by applying it to a 4-port board-to-board interconnect.
Abstract 3925: Characterization of complex chromosomal aberrations in prostate cancer from whole genome sequencing (2011)

Abstract Prostate cancer is the second most common cause of male cancer deaths in the United States, accounting for 200,000 new cases and 32,000 deaths per year. Chromosomal rearrangements comprise a major mechanism driving prostate carcinogenesis. For example, recurrent gene fusions that render ETS transcription factors under the control of androgen-responsive promoters are present in the majority of prostate cancers. Other types of somatic alterations, such as base substitutions, small insertions/deletions, and chromosomal copy number alterations, have also been described, yet the full repertoire of genomic alterations that underlie primary human prostate cancer remains incompletely characterized. We present here the most comprehensive genome sequencing effort in prostate cancer reported to date. We have characterized the complete genomes of 7 primary prostate cancers and patient-matched normal samples using massively parallel sequencing technology. We observed a mean mutation frequency of 0.9 per megabase, consistent with what has been reported for other tumor types. However, our results indicate that translocations and other chromosomal rearrangements are far more common than expected, with a median of 90 per prostate cancer genome. Several tumors contained chains of balanced rearrangements involving multiple loci associated with known cancer genes. We observed a striking and unexpected relationship between rearrangement breakpoints and chromatin structure, which differed for tumors harboring the ETS gene fusion TMPRSS2-ERG and tumors lacking ETS fusions. We also observed an enrichment of point mutations near rearrangement breakpoints. Three of seven tumors contained rearrangements that disrupted CADM2, a nectin-like member of the immunoglobulin-like cell adhesion molecules; recurrent CADM2 rearrangements were also detected in an independent cohort by fluorescent in situ hybridization (FISH). Four tumors harbored rearrangements disrupting either PTEN, a prostate tumor suppressor, or MAGI2, a PTEN interacting protein not previously implicated in prostate cancer. Together, these results illuminate potential avenues for target discovery and reveal the potential of complex rearrangements to engage prostate tumorigenic mechanisms. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3925. doi:10.1158/1538-7445.AM2011-3925
Modulation of acute immune complex-mediated tissue injury by the presence of polyionic substances. (1987)

Considerable attention has been focused on the role of electrostatic charge in the pathogenesis of immune complex-mediated tissue injury. The authors have examined the ability of cationic (histone, polyhistidine, polyarginine) and anionic (polyanetholsulfonate) polyelectrolytes to modulate acute immune complex-mediated tissue injury. Tissue injury elicited in rats by the reversed dermal Arthus reaction was increased 26-43% by addition of polyelectrolytes to antibody prior to its intradermal injection. Kinetic studies using 111In-labeled neutrophils indicated that the enhanced tissue injury was not the result of increased influx of neutrophils. Infusion of polyethylene glycol-conjugated superoxide dismutase prior to induction of the Arthus reaction resulted in 40-68% suppression of tissue injury. Concomitant in vitro functional studies (enzyme secretion, O-2 and H2O2 generation, and chemiluminescence) of rat neutrophils demonstrated that addition of polyelectrolytes to preformed immune complexes (IgG-bovine serum albumin) resulted in marked increases in O-2, H2O2, and chemiluminescence, but no increases in enzyme secretion, compared with neutrophils stimulated with immune complexes alone. The cationic polyelectrolytes did not alter the capacity of preformed immune complexes to activate complement in vitro. These studies suggest that both cationic and anionic polyelectrolytes can increase the pathogenic potential of immune complexes and that this modulation is, at least in part, mediated by enhanced generation of toxic oxygen-derived metabolites by neutrophils.
Comparative study of antenna elements for TDRSS enhanced multiple access system (2006)

The tracking and data relay satellite system (TDRSS) is a constellation of geosynchronous satellites, which are the primary source of space-to-ground voice, data and telemetry for the space shuttle. The satellites also provide communications with the International Space Station and scientific spacecraft in low-Earth orbit such as the Hubble Space Telescope. Integral to the design of the TDRSS class of satellites is an architecture consisting of a multiple access (MA), S-band, phased array antenna. This MA system receives and relays data simultaneously from five lower data-rate users and transmits commands to a single user. This paper describes a study (design, fabrication, and testing) of several modified antenna elements for the enhanced MA phased array. Several antenna elements were investigated including a helix antenna, a novel short backfire antenna excited with a circular waveguide, and a corrugated horn antenna. The results for each element in terms of performance; fabrication, assembly and tuning complexity; size and mass are compared
Polarization insensitive broadband transparent DCF module (1999)

A polarization insensitive broadband transparent DCF module with faraday rotator mirror, Raman-amplified by single polarization laser-diodes pumping, was fabricated. Though Raman amplification is polarization dependent process, influence of polarization caused by single polarization Laser-diodes is almost suppressed. The DCF module compensates dispersion and dispersion slope over wide wavelength range without loss increase. The total dispersion and dispersion slope of the DCF module and 40km SMF between 1530nm and 1620nm were less than 2ps/nm and less than 0.03ps/nm2 for 1km SMF transmission line, respectively.
Task-Oriented Data Compression for Multi-Agent Communications Over Bit-Budgeted Channels (2022)

&lt;p&gt;Various applications for inter-machine communications are on the rise. Whether for autonomous vehicles or the internet of everything, machines are more connected than ever to improve their performance in fulfilling a given task. While in traditional communications, the goal has often been to reconstruct the original message, under the emerging task-oriented paradigm, the purpose of communication is to enable the receiving end to make more informed decisions or more precise estimates/computations. Motivated by these recent developments, in this paper, we perform an indirect design of the communications in a multi-agent system (MAS) in which agents cooperate to maximize the averaged sum of discounted one-stage rewards of a collaborative task. Due to the bit-budgeted communications between the agents, each agent should efficiently represent its local observation and communicate an abstracted version of the observations to improve the collaborative task performance. We first show that this problem can be approximated as a form of data-quantization problem which we call task-oriented data compression (TODC). We then introduce the state-aggregation for information compression algorithm (SAIC) to solve the formulated TODC problem. It is shown that SAIC is able to achieve near-optimal performance in terms of the achieved sum of discounted rewards. The proposed algorithm is applied to a geometric consensus problem and its performance is compared with several benchmarks. Numerical experiments confirm the promise of this indirect design approach for task-oriented multi-agent communications.&lt;/p&gt;
Uncertainty-principle noise in vacuum-tunneling transducers (1992)

The fundamental sources of noise in a vacuum-tunneling probe used as an electromechanical transducer to monitor the location of a test mass are examined using a first-quantization formalism. We show that a tunneling transducer enforces the Heisenberg uncertainty principle for the position and momentum of a test mass monitored by the transducer through the presence of two sources of noise: the shot noise of the tunneling current and the momentum fluctuations transferred by the tunneling electrons to the test mass. We analyze a number of cases including symmetric and asymmetric rectangular potential barriers and a barrier in which there is a constant electric field. Practical configurations for reaching the quantum limit in measurements of the position of macroscopic bodies with such a class of transducers are studied.
Marginal role of von Willebrand factor-binding protein and coagulase in the initiation of endocarditis in rats with catheter-induced aortic vegetations (2018)

Staphylococcus aureus is the leading cause of infective endocarditis (IE). While the role of S. aureus cell-wall associated protein clumping factor A (ClfA) in promoting IE has been already demonstrated, that of the secreted plasma-clotting factors staphylocoagulase (Coa) and von Willebrand factor-binding protein (vWbp) has not yet been elucidated. We investigated the role of Coa and vWbp in IE initiation in rats with catheter-induced aortic vegetations, using Lactococcus lactis expressing coa, vWbp, clfA or vWbp/clfA, and S. aureus Newman Δcoa, ΔvWbp, ΔclfA or Δcoa/ΔvWbp/ΔclfA mutants. vWbp-expression increased L. lactis valve infection compared to parent and coa-expressing strains (incidence: 62%, versus 0% and 13%, respectively; P < 0.01). Likewise, expression of clfA increased L. lactis infectivity (incidence: 80%), which was not further affected by co-expression of vWbp. In symmetry, deletion of the coa or vWbp genes in S. aureus did not decrease infectivity (incidence: 68 and 64%, respectively) whereas deletion of clfA did decrease valve infection (incidence: 45%; P = 0.03 versus parent), which was not further affected by the triple deletion Δcoa/ΔvWbp/ΔclfA (incidence: 36%; P > 0.05 versus ΔclfA mutant). Coa does not support the initial colonization of IE (in L. lactis) without other key virulence factors and vWbp contributes to initiation of IE (in L. lactis) but is marginal in the present of ClfA.
Targeted Nanotherapeutics for Respiratory Diseases: Cancer, Fibrosis, and Coronavirus (2020)

Systemic delivery of therapeutics for treatment of lung diseases has several limitations including poor organ distribution of delivered payload with relatively low accumulation of active substances in the lungs and severe adverse side effects. In contrast, nanocarrier based therapeutics provide a broad range of opportunities due to their ability to encapsulate substances with different aqueous solubility, transport distinct types of cargo, target therapeutics specifically to the deceased organ, cell, or cellular organelle limiting adverse side effects and increasing the efficacy of therapy. Moreover, many nanotherapeutics can be delivered by inhalation locally to the lungs avoiding systemic circulation. In addition, nanoscale based delivery systems can be multifunctional, simultaneously carrying out several tasks including diagnostics, treatment and suppression of cellular resistance to the treatment. Nanoscale delivery systems improve the clinical efficacy of conventional therapeutics allowing new approaches for the treatment of respiratory diseases which are difficult to treat or possess intrinsic or acquired resistance to treatment. The present review summarizes recent advances in the development of nanocarrier based therapeutics for local and targeted delivery of drugs, nucleic acids and imaging agents for diagnostics and treatment of various diseases such as cancer, cystic fibrosis, and coronavirus.
Optimization of a Diamond Nitrogen Vacancy Centre Magnetometer for Sensing of Biological Signals (2020)

Sensing of signals from biological processes, such as action potential propagation in nerves, are essential for clinical diagnosis and basic understanding of physiology. Sensing can be performed electrically by placing sensor probes near or inside a living specimen or dissected tissue using well established electrophysiology techniques. However, these electrical probe techniques have poor spatial resolution and cannot easily access tissue deep within a living subject, in particular within the brain. An alternative approach is to detect the magnetic field induced by the passage of the electrical signal, giving the equivalent readout without direct electrical contact. Such measurements are performed today using bulky and expensive superconducting sensors with poor spatial resolution. An alternative is to use nitrogen vacancy (NV) centres in diamond that promise biocompatibilty and high sensitivity without cryogenic cooling. In this work we present advances in biomagnetometry using NV centres, demonstrating magnetic field sensitivity of approximately 100 pT/sqrt(Hz) in the DC/low frequency range using a setup designed for biological measurements. Biocompatibility of the setup with a living sample (mouse brain slice) is studied and optimized, and we show work toward sensitivity improvements using a pulsed magnetometry scheme. In addition to the bulk magnetometry study, systematic artifacts in NV-ensemble widefield fluorescence imaging are investigated.