gebhart/patrepeval huggingface dataset:
Supplementary Figures 1-8, Table 1 from Adjuvant Combination and Antigen Targeting as a Strategy to Induce Polyfunctional and High-Avidity T-Cell Responses against Poorly Immunogenic Tumors (2023)

Supplementary Figures 1-8, Table 1 from Adjuvant Combination and Antigen Targeting as a Strategy to Induce Polyfunctional and High-Avidity T-Cell Responses against Poorly Immunogenic Tumors
The space weather x-ray spectrometer for the Helianthus sub-L1 mission with solar photonic propulsion (2022)

Helianthus is a phase A study of a space weather station with solar photonic propulsion. The scientific payload will be made of: an x-ray spectrometer to detect solar flares; SailCor, a coronagraph with a wide field of view; a plasma analyzer; a magnetometer. The maximum allowed mass for the entire scientific payload shall not exceed 5 kg. The two imaging devices (coronagraph and X-ray spectrometer) are of fundamental importance for the sake of remotely and timely mapping the status of the Sun and provide Earth stations with early warning of potentially disruptive events. An extensive research on available x-Ray detectors was performed and the Amptek FAST-SDD spectrometer was selected. It is a very light, compact and vacuum compatible instrument. In order to prove the device readiness for flight, a measurement campaign was organized to investigate its performance in terms of spectral range, spectral resolution, dynamic range and response speed. The campaign was run at the INAF XACT facility in Palermo (Italy). This paper describes the facility, the measurement campaign and the results.
Effect of waveforms on morphology development in chaotic mixing of polymers (2004)

Abstract The effect of waveforms of rotor motion in a chaotic mixing device on the development of morphology in the blending of polypropylene (PP) and polyamide 6 (PA6) was investigated. The rotor motion was delivered in a steady and time‐periodic manner and the mixing effectiveness was evaluated in terms of Poincaré maps and stretching distribution, the speed of conversion of PP‐phase into droplets, and droplet size distribution. The pathway of morphology development, such as deformation of the PP‐phase into lamella, fibrils, and droplets, was found not to depend on the nature of the waveform. However, the makeup of each morphological form depended strongly on the particular waveform used. The best results were obtained when the rotor motion was delivered using a sine waveform. In this case, the PP‐phase turned most rapidly into fibrils and droplets and the droplets were of more uniform size. The square waveform, although produced higher mean stretching and showed more uniform mixing in Poincaré maps, yielded large‐size droplets, purportedly through premature breakup of the fibrils in the zones of weak flow, such as in the vicinity of the stationary rotors. © 2004 American Institute of Chemical Engineers AIChE J, 50: 2346–2358, 2004
733: Pre-Operative Nomogram for Predicting Biochemical-Free Probability Following Salvage Cryotherapy for Prostate Cancer (2007)

You have accessJournal of UrologyPodium 24, Monday, May 21, 2007, 8:00 - 10:00 am1 Apr 2007733: Pre-Operative Nomogram for Predicting Biochemical-Free Probability Following Salvage Cryotherapy for Prostate Cancer Philippe E. Spiess, Aaron E. Katz, Joseph L. Chin, Duke Bahn, Jeffrey K. Cohen, Katsuto Shinohara, Mike Hernandez, Julie Bossier, and Louis L. Pisters Philippe E. SpiessPhilippe E. Spiess More articles by this author , Aaron E. KatzAaron E. Katz More articles by this author , Joseph L. ChinJoseph L. Chin More articles by this author , Duke BahnDuke Bahn More articles by this author , Jeffrey K. CohenJeffrey K. Cohen More articles by this author , Katsuto ShinoharaKatsuto Shinohara More articles by this author , Mike HernandezMike Hernandez More articles by this author , Julie BossierJulie Bossier More articles by this author , and Louis L. PistersLouis L. Pisters More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30973-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "733: Pre-Operative Nomogram for Predicting Biochemical-Free Probability Following Salvage Cryotherapy for Prostate Cancer." The Journal of Urology, 177(4S), p. 246 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 246 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Philippe E. Spiess More articles by this author Aaron E. Katz More articles by this author Joseph L. Chin More articles by this author Duke Bahn More articles by this author Jeffrey K. Cohen More articles by this author Katsuto Shinohara More articles by this author Mike Hernandez More articles by this author Julie Bossier More articles by this author Louis L. Pisters More articles by this author Expand All Advertisement PDF downloadLoading ...
Novel LC/MS/MS and High-Throughput Mass Spectrometric Assays for Monoacylglycerol Acyltransferase Inhibitors (2017)

Monoacylglycerol acyltransferase enzymes (MGAT1, MGAT2, and MGAT3) convert monoacylglycerol to diacylglycerol (DAG). MGAT1 and MGAT2 are both implicated in obesity-related metabolic diseases. Conventional MGAT enzyme assays use radioactive substrates, wherein the product of the MGAT-catalyzed reaction is usually resolved by time-consuming thin layer chromatography (TLC) analysis. Furthermore, microsomal membrane preparations typically contain endogenous diacylglycerol acyltransferase (DGAT) from the host cells, and these DGAT activities can further acylate DAG to form triglyceride (TG). Our mass spectrometry (liquid chromatography-tandem mass spectrometry, or LC/MS/MS) MGAT2 assay measures human recombinant MGAT2-catalyzed formation of didecanoyl-glycerol from 1-decanoyl-rac-glycerol and decanoyl-CoA, to produce predominantly 1,3-didecanoyl-glycerol. Unlike 1,2-DAG, 1,3-didecanoyl-glycerol is proved to be not susceptible to further acylation to TG. 1,3-Didecanoyl-glycerol product can be readily solubilized and directly subjected to high-throughput mass spectrometry (HTMS) without further extraction in a 384-well format. We also have established the LC/MS/MS MGAT activity assay in the intestinal microsomes from various species. Our assay is proved to be highly sensitive, and thus it allows measurement of endogenous MGAT activity in cell lysates and tissue preparations. The implementation of the HTMS MGAT activity assay has facilitated the robust screening and evaluation of MGAT inhibitors for the treatment of metabolic diseases.
Understanding the physical and material dynamics of multipulse femtosecond laser interactions with surfaces (2013)

We describe the evolution of laser damage spots on bulk nickel generated by multipulse femtosecond laser irradiation with a 100 &mu;m x 100 μm square flat-top beam profile as a function of the laser fluence and the number of pulses incident on the target. This large-area irradiation simulates conditions associated with the interaction of femtosecond laser pulses on a remote target. The larger area laser damage sites are characterized either by a series of self-organized surface structures with micro- and nanoscale features or a deep circular pit rather than a crater that mirrors the beam profile. Furthermore, the ablation rate of the deepest feature sharply increases above a laser fluence of 2 J/cm<sup>2</sup>; this increase is associated with the creation of a deep circular ablation pit generated during ablation with the first few pulses on the sample that continuously grows upon multipulse irradiation due to the focusing of incident laser energy into the pit by the sloped pit surfaces.
Thin-oxide charging damage to microelectronic test structures in an electron-cyclotron-resonance plasma (1995)

Processing yields in electron-cyclotron-resonance (ECR) and other high-density plasma sources will be increasingly limited by plasma-induced damage. This work investigates the effects of plasma nonuniformities on charging damage to polysilicon-gate MOS capacitor test structures exposed to O2 ECR plasmas. The nonuniformities were produced by independently biasing electrodes located above the wafer. The damage was characterized with ramp-voltage breakdown measurements. Comparison of calculated profiles of the potential difference across the gate-oxide layers of the MOS capacitors with whole wafer maps of the breakdown voltage measurements shows that maximum damage occurs where the oxide potential difference is largest but only in the presence of plasma nonuniformities.
A Supramolecular Protecting Group Strategy Introduced to the Organic Solid State: Enhanced Reactivity through Molecular Pedal Motion (2011)

A supramolecular protecting group strategy has been applied to achieve solid-state photodimerizations of olefins lined with a combination of hydrogen-bond-donor and -acceptor groups. Esters were used as protecting groups to generate head-to-head photodimers that were readily converted into diacids. A protected olefin equipped with a stilbene unit exhibits enhanced reactivity that is ascribed to pedal motions in the solid state (orange hexagons: template: blur circles: recognition sites). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Evaluation of AISI Type 304 stainless steel as a suitable surface material for evaluating the efficacy of peracetic acid-based disinfectants against Clostridium difficile spores (2017)

Disinfectants play an important role in controlling microbial contamination on hard surfaces in hospitals. The effectiveness of disinfectants in real life can be predicted by laboratory tests that measure killing of microbes on carriers. The modified Quantitative Disk Carrier Test (QCT-2) is a standard laboratory method that employs American Iron and Steel Institute (AISI) Type 430 stainless steel carriers to measure hospital disinfectant efficacy against Clostridium difficile spores. The formation of a rust-colored precipitate was observed on Type 430 carriers when testing a peracetic acid (PAA)-based disinfectant with the QCT-2 method. It was hypothesized that the precipitate was indicative of corrosion of the Type 430 carrier, and that corrosion could impact efficacy results. The objective of this study was to compare the suitability of AISI Type 430 to Type 304 stainless steel carriers for evaluating PAA-based disinfectants using the QCT-2 method. Type 304 is more corrosion-resistant than Type 430, is ubiquitous in healthcare environments, and is used in other standard methods. Suitability of the carriers was evaluated by comparing their impacts on efficacy results and PAA degradation rates. In efficacy tests with 1376 ppm PAA, reductions of C. difficile spores after 5, 7 and 10 minutes on Type 430 carriers were at least about 1.5 log10 lower than reductions on Type 304 carriers. In conditions simulating a QCT-2 test, PAA concentration with Type 430 carriers was reduced by approximately 80% in 10 minutes, whereas PAA concentration in the presence of Type 304 carriers remained stable. Elemental analyses of residues on each carrier type after efficacy testing were indicative of corrosion on the Type 430 carrier. Use of Type 430 stainless steel carriers for measuring the efficacy of PAA-based disinfectants should be avoided as it can lead to an underestimation of real life sporicidal efficacy. Type 304 stainless steel carriers are recommended as a suitable alternative.
Real-Time Wireless Data Acquisition System (2007)

Current and future aerospace requirements demand the creation of a new breed of sensing devices, with emphasis on reduced weight, power consumption, and physical size. This new generation of sensors must possess a high degree of intelligence to provide critical data efficiently and in real-time. Intelligence will include self-calibration, self-health assessment, and pre-processing of data at the sensor level. Most of these features are already incorporated in the Wireless Sensors Network (SensorNet(TradeMark)), developed by the Instrumentation Group at Kennedy Space Center (KSC). A system based on the SensorNet(TradeMark) architecture consists of data collection point(s) called Central Stations (CS) and intelligent sensors called Remote Stations (RS) where one or more CSs can be accommodated depending on the specific application. The CS's major function is to establish communications with the Remote Stations and to poll each RS for data and health information. The CS also collects, stores and distributes these data to the appropriate systems requiring the information. The system has the ability to perform point-to-point, multi-point and relay mode communications with an autonomous self-diagnosis of each communications link. Upon detection of a communication failure, the system automatically reconfigures to establish new communication paths. These communication paths are automatically and autonomously selected as the best paths by the system based on the existing operating environment. The data acquisition system currently under development at KSC consists of the SensorNet(TradeMark) wireless sensors as the remote stations and the central station called the Radio Frequency Health Node (RFHN). The RFF1N is the central station which remotely communicates with the SensorNet(TradeMark) sensors to control them and to receive data. The system's salient feature is the ability to provide deterministic sensor data with accurate time stamps for both time critical and non-time critical applications. Current wireless standards such as Zigbee(TradeMark) and Bluetooth(Registered TradeMark) do not have these capabilities and can not meet the needs that are provided by the SensorNet technology. Additionally, the system has the ability to automatically reconfigure the wireless communication link to a secondary frequency if interference is encountered and can autonomously search for a sensor that was perceived to be lost using the relay capabilities of the sensors and the secondary frequency. The RFHN and the SensorNet designs are based on modular architectures that allow for future increases in capability and the ability to expand or upgrade with relative ease. The RFHN and SensorNet sensors .can also perform data processing which forms a distributed processing architecture allowing the system to pass along information rather than just sending raw data points to the next higher level system. With a relatively small size, weight and power consumption, this system has the potential for both spacecraft and aircraft applications as well as ground applications that require time critical data.
IL-21 Induces Apoptosis of Antigen-Specific CD8+ T Lymphocytes (2007)

IL-21, a member of the common gamma-chain family of cytokines, has pleiotropic effects on T, B, and NK cells. We found that IL-21 and the prototype common gamma-chain cytokine IL-2 can stimulate proliferation and cytokine secretion by Ag-specific rhesus monkey CD8+ T cells. However, unique among the members of this family of cytokines, we found that IL-21 drives these cells to apoptosis by down-regulation of Bcl-2. These findings suggest that IL-21 may play an important role in the contraction of CD8+ T cell responses.
A 342mW mobile application processor with full-HD multi-standard video codec (2009)

Today's cellular phones must support full high-definition (full-HD) video in multiple video formats, such as H.264 and MPEG-2/-4, with low power consumption. Full-HD video processing requires six times the data bandwidth and is more computationally intensive than conventional standard-definition (SD) video. The trade-off between flexibility, performance and power consumption is a key focus of video-codec design. Homogeneous multi-core processors are power-consuming and achieving high-throughput is difficult [1]. While dedicated circuits can minimize power consumption, the dedicated decoders and encoders in previous reports [2, 3] have difficulty performing all of the media processing that is indispensable for a modern cellular phone [4]. In this paper, we have integrated a mobile application processor featuring a two-stage-processing video codec, tile-based address-translation circuits, and several audio/visual intellectual property (IP) modules.
Rapid isotropic 3D‐sodium MRI of the knee joint in vivo at 7T (2009)

The preliminary results suggest that sodium imaging at 7T may be a feasible potential alternative for physiologic OA imaging and clinical diagnosis.
Proceedings of the 2nd Workshop on Smart Energy Grid Security (2014)

It is our great pleasure to welcome you to the 2nd Smart Energy Grid Security (SEGS) Workshop. SEGS 2014 aims to foster innovative research and discussion about smart energy grid security and privacy challenges, approaches, and solutions. SEGS'14 takes places in Scottsdale, Arizona, in conjunction with ACM CCS 2014. In the last year, the digitalization of the power grids has been pushed further, with an increasing number of countries engaging in large scale rollouts of smart grid components. While the topic of security is getting more attention, we still face insufficient understanding and communication between the electricity sector and the security community. Given the long lifetime of the systems deployed now, and the fact that the first large scale attacks have already been seen, increasing this communication and working towards applicable solutions is more important than ever before. In spite of the growing number of events and conferences focusing on the digital grid, the gap in the security research community specially addressing smart grids is still wide, and many of the systems rolled out now have a wealth of unaddressed security issues. This workshop aims to fill that void and encourage more research into the area of smart grid security by providing a forum for security researchers to present their work. This workshop serves as an opportunity to foster collaboration between the power industry and the ACM CCS research community. The scope of the workshop encompasses all aspects of the smart grid, including distribution, transmission, generation, metering, e-mobility, and integration of distributed energy resources. SEGS publications offer perspectives from both academia and industry, and present novel research on theoretical and practical aspects of smart grid security and privacy, including design, analysis, experimentation, and fielded systems. SEGS also aims for the integration of other communities, such as law, economics, and HCI, which present these communities' perspectives on technological issues. We hope that the workshop will provide the participants with the opportunity to share ideas and practical experience, and will result in progress towards more resilient power systems. TOPICS OF INTEREST The SEGS Workshop focuses on the following topics: Smart grid architectures and modelsSmart grid networks and communicationSecurity and dependability in safetycritical, real-time systemsData protection and privacyGrid managementTrust and assuranceIntrusion detection and monitoring on smart gridsAlgorithms and protocols for critical infrastructuresRisk and threat analysisSmartgrid standards, testing, andcertificationTestbeds and field trialsUsability and legal issues on grid securityCloud computing and smart grids
Accurate Mass Liquid Chromatography/Mass Spectrometry on Orthogonal Acceleration Time-of-Flight Mass Analyzers Using Switching between Separate Sample and Reference Sprays. 1. Proof of Concept (2000)

This paper describes the use of two separate electrosprays for introducing sample and reference for accurate mass liquid chromatography/mass spectrometry (LC/MS) on an orthogonal acceleration time-of-flight mass analyzer. This is carried out using an adaptation of the multiplexed electrospray ion source in which only two of the sprays are utilized. Results are shown for the positive ion detection of trace-level components in complex matrixes and good mass accuracies are obtained, even for very low level components. An example of accurate mass measurements obtained using negative ion LC/MS is also shown. To obtain additional structural information, an example of cone voltage fragmentation is included and shows that good mass accuracy can be obtained for both precursor and fragment ions.
Quiet connections: Reduced fronto‐temporal connectivity in nondemented Parkinson's Disease during working memory encoding (2016)

Abstract Parkinson's disease (PD) is a common neurodegenerative disorder characterized primarily by motor symptoms such as bradykinesia, muscle rigidity, and resting tremor. It is now broadly accepted that these motor symptoms frequently co‐occur with cognitive impairments, with deficits in working memory and attention being among the most common cognitive sequelae associated with PD. While these cognitive impairments are now recognized, the underlying neural dynamics and precise regions involved remain largely unknown. To this end, we examined the oscillatory dynamics and interregional functional connectivity that serve working memory processing in a group of unmedicated adults with PD and a matched group without PD. Each participant completed a high‐load, Sternberg‐type working memory task during magnetoencephalography (MEG), and we focused on the encoding and maintenance phases. All data were transformed into the time–frequency domain and significant oscillatory activity was imaged using a beamforming approach. Phase‐coherence (connectivity) was also computed among the brain subregions exhibiting the strongest responses. Our most important findings were that unmedicated patients with PD had significantly diminished working memory performance (i.e., accuracy), and reduced functional connectivity between left inferior frontal cortices and left supramarginal–superior temporal cortices compared to participants without PD during the encoding phase of working memory processing. We conclude that patients with PD have reduced neural interactions between left prefrontal executive circuits and temporary verbal storage centers in the left supramarginal/superior temporal cortices during the stimulus encoding phase, which may underlie their diminished working memory function. Hum Brain Mapp 37:3224–3235, 2016 . © 2016 Wiley Periodicals, Inc.
Females' and males' end-user debugging strategies : a sensemaking perspective (2009)

Although there have been decades of research into how professional programmers debug, only recently has work begun to emerge about how end-user programmers attempt to debug their programs. Without understanding how end-user programmers approach debugging, we cannot build tools to adequately support their needs. To help fill this need, this paper reports the results of a qualitative empirical study that investigates in detail female and male end-user programmers ‘ sensemaking about a spreadsheet‘s correctness. Using our study‘s data, we derived a sensemaking model for end-user debugging and then categorized participants ‘ activities and verbalizations according to this model. We then used the categorized data to investigate how our participants went about debugging. Among the results are identification of the prevalence of information foraging during end-user debugging, two successful strategies for traversing the sensemaking model, ties to gender differences in the literature, sensemaking sequences leading to debugging progress, and sensemaking sequences tied with troublesome points in the debugging process. The results also reveal new implications for the design of spreadsheet tools to support female and male end-user programmers ‘ sensemaking as they debug.