gebhart/patrepeval huggingface dataset:
A novel addition polyimide adhesive (1981)

An addition polyimide adhesive, LARC 13, was developed which shows promise for bonding both titanium and composites for applications which require service temperatures in excess of 533 K. The LARC 13 is based on an oligomeric bis nadimide containing a meta linked aromatic diamine. The adhesive melts prior to polymerization due to its oligomeric nature, thereby allowing it to be processed at 344 kPa or less. Therefore, LARC 13 is ideal for the bonding of honeycomb sandwich structures. After melting, the resin thermosets during the cure of the nadic endcaps to a highly crosslinked system. Few volatiles are evolved, thus allowing large enclosed structures to be bonded. Preparation of the adhesive as well as bonding, aging, and testing of lap shear and honeycomb samples are discussed.
Charge‐Transfer Processes in Zeolites: Toward Better Artificial Photosynthetic Models (1996)

This chapter contains sections titled: Introduction What are Zeolites? Charge-Transfer Processes in Zeolites Electrochemically Induced Charge Transfer in Zeolites Photochemical Assemblies within Zeolites Chemical Reactions with Photochemical Redox Species Charge Transfer Through Intrazeolitic Conducting Chains Needs for the Future
IMM experimentation in the next frontier: Emcore'S participation in the MISSE-8 program (2010)

In collaborations with both Lockheed-Martin (LM) and the Air Force Research Laboratory (AFRL), Emcore has incorporated its cutting-edge IMM cell technologies on MISSE-8 in a variety of cell form factors and two distinct configurations. The first is a double coverglass (DCG) arrangement, where adhesive and coverglass are attached to both the front and backsides of the solar cell, and in the second configuration the IMM cell was mounted to a rigid, lightweight, CTE-matched substrate. Pre-build test coupons were subjected to 1124 thermal cycles from -100 to 100°C, and showed no electrical degradation in six out of seven cells/strings, with the lone degraded cell exhibiting just a 3.5% loss in Jsc and no change in Voc or FF. The average AM0 efficiency (solar constant = 1353 W/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) of the IMM3J cells flown in this experiment have an average efficiency of 31.3% (omitting an anomalously low-perfoming cell), and the 4cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> IMM4J cells 33.1%.
<title>Scaled discrete cosine transform algorithms for JPEG and MPEG implementations on fused multiply/add architectures</title> (1991)

We introduce a new scaled Discrete Cosine Transform (SDCT) and inverse SDCTs optimized for architectures where a primitive arithmetic operation is a fused multiply/add. Explicit algorithms are derived for 1- dimensional inputs of 8 points and for 2-dimensional inputs of 8 X 8 points. The latter require 416 operations. When constants are programmable, descaling plus computing the inverse DCT on 8 X 8 points can be done with 417 operations.
Federal Hill Project: Interview with Vincent Pantalone by Eleanor Dyer - June 28, 1978 - TAPE 24 (1978)

Interview discusses the life of Vincent Pantalone in Italy and his experience since moving to the United States of America. Topics include religion, gender, business, and the Federal Hill neighborhood in Providence, Rhode Island.
Performance analysis of spatial multiplexing MIMO-OFDM systems under frequency-selective I/Q imbalances (2009)

This paper studies the impact of one important radio transceiver impairment, namely the I/Q imbalance, on the link performance of spatial multiplexing MIMO-OFDM systems. A closed-form solution for the effective signal-to-interference-plus-noise-ratio (SINR) at the input of the receiver detection stage due to frequency-selective transmitter and receiver I/Q imbalances is derived, taking also the effects of fading multipath radio channel and additive noise into account. As will be shown, the derived SINR can be directly mapped to the achievable detection error rate at high SNR regime, yielding a valuable analytical tool for radio transceiver designers to analyze the imbalance effects at link-level without any actual data simulations. The analytical outcomes are also verified using extensive computer simulations backing up the theoretical studies. In general, the obtained results indicate that I/Q imbalance can easily become a limiting factor to the achievable link performance in future spatial multiplexing MIMO-OFDM systems, and thus should be carefully mitigated using proper digital and/or analog signal processing.
Demonstration that endoplasmic reticulum-associated degradation of glycoproteins can occur downstream of processing by endomannosidase (2011)

During quality control in the ER (endoplasmic reticulum), nascent glycoproteins are deglucosylated by ER glucosidases I and II. In the post-ER compartments, glycoprotein endo-α-mannosidase provides an alternative route for deglucosylation. Previous evidence suggests that endomannosidase non-selectively deglucosylates glycoproteins that escape quality control in the ER, facilitating secretion of aberrantly folded as well as normal glycoproteins. In the present study, we employed FOS (free oligosaccharides) released from degrading glycoproteins as biomarkers of ERAD (ER-associated degradation), allowing us to gain a global rather than single protein-centred view of ERAD. Glucosidase inhibition was used to discriminate between glucosidase- and endomannosidase-mediated ERAD pathways. Endomannosidase expression was manipulated in CHO (Chinese-hamster ovary)-K1 cells, naturally lacking a functional version of the enzyme, and HEK (human embryonic kidney)-293T cells. Endomannosidase was shown to decrease the levels of total FOS, suggesting decreased rates of ERAD. However, following pharmacological inhibition of ER glucosidases I and II, endomannosidase expression resulted in a partial switch between glucosylated FOS, released from ER-confined glycoproteins, to deglucosylated FOS, released from endomannosidase-processed glycoproteins transported from the Golgi/ERGIC (ER/Golgi intermediate compartment) to the ER. Using this approach, we have identified a previously unknown pathway of glycoprotein flow, undetectable by the commonly employed methods, in which secretory cargo is targeted back to the ER after being processed by endomannosidase.
Active optical device enabled by dielectric metamaterials (2023)

An array of dielectric resonators is formed on a substrate. Each resonator includes an active medium having an optical transition that is operative in a process of photodetection or photoemission. The active media each include a quantum well multilayer. The dielectric resonators in the array are each dimensioned to provide a resonance that lies substantially at the frequency of the optical transition.
β-1,4-Glycanases of Cellulomonas fimi: Families, Mechanisms, and Kinetics (1996)

Four endoglucanases, two cellobiohydrolases and a mixed function exoglucanase-xylanase from Cellulomonas fimi are modular proteins comprising from two to six domains. All of them contain a catalytic domain (CD) and at least one cellulose-binding domain (CBD). The CDs come from five of the families of glycoside hydrolases; the CBDs from three of the families of CBDs, although all but one of the enzymes has a CBD from family II. The two cellobiohydrolases attack cellulose molecules from opposite ends. The CDs and the CBDs function independently of each other when separated by proteolysis or genetic engineering. The enzymes interact with cellulose in two ways. The CDs have weak affinity for substrate, relative to the CBDs, and catalyze hydrolysis of glycosidic bonds with inversion or retention of anomeric configuration, depending on the CD. The CBDs have much greater affinities for cellulose, with Ka values of the order of 0.5-1.0 μM for the family II CBDs. The family II CBDs adsorb to both crystalline and amorphous cellulose; the family IV CBD from endoglucanase CenC adsorbs to amorphous but not to crystalline cellulose. CBDCex from the exoglucanase-xylanase Cex, is a β-barrel in solution, with extensive β-sheet structure; three tryptophans, which participate in binding to cellulose, are adjacent in space and exposed on the surface of the β-barrel. Adsorption of CBDCex to crystalline cellulose is entropically driven. Although CBDCex appears to bind irreversibly, the binding is dynamic and the polypeptide is mobile on the cellulose surface.
Accelerated vaccine development against emerging infectious diseases (2012)

Emerging and re-emerging infectious diseases represent a major challenge to vaccine development since it involves two seemingly contradictory requirements. Rapid and flexible vaccine generation while using technologies and processes that can facilitate accelerated regulatory review. Development in the "-omics" in combination with advances in vaccinology offer novel opportunities to meet these requirements. Here we describe how a consortium of five different organizations from academia and industry is addressing these challenges. This novel approach has the potential to become the new standard in vaccine development allowing timely deployment to avert potential pandemics.
Routing and wavelength assignment of scheduled lightpath demands (2003)

We present algorithms that compute the routing and wavelength assignment (RWA) for scheduled lightpath demands in a wavelength-switching mesh network without wavelength conversion functionality. Scheduled lightpath demands are connection demands for which the setup and teardown times are known in advance. We formulate separately the routing problem and the wavelength assignment problem as spatio-temporal combinatorial optimization problems. For the former, we propose a branch and bound algorithm for exact resolution and an alternative tabu search algorithm for approximate resolution. A generalized graph coloring approach is used to solve the wavelength assignment problem. We compared the proposed algorithms to an RWA algorithm that sequentially computes the route and wavelength assignment for the scheduled lightpath demands.
Supplementary Figure S5 from Integrated Human and Murine Clinical Study Establishes Clinical Efficacy of Ruxolitinib in Chronic Myelomonocytic Leukemia (2023)

&lt;p&gt;Supplementary Figure S5 depicts endpoint assessments compared between vehicle-treated and ruxolitinib-treated patient-derived xenograft mice.&lt;/p&gt;
Kinematic manipulability of general constrained rigid multibody systems (1999)

This paper extends the kinematic manipulability concept commonly used for serial manipulators to general constrained rigid multibody systems. Examples of such systems include multiple cooperating manipulators, multiple fingers holding a payload, multileg walking robots, and variable geometry trusses. Explicit formulas for velocity and force manipulability ellipsoids are derived and their duality explained. Singularities are classified into two types: 1) unmanipulable singularity; 2) unstable singularity. The former is similar the singularities in serial chains where velocity manipulability ellipsoid is degenerate and force manipulability ellipsoid infinite. The latter is unique to parallel mechanisms, the velocity manipulability ellipsoid becomes infinite and force manipulability degenerate. In the case of multifinger grasp, these concepts correspond to unmanipulable or unstable grasps.
Low-Density Lipoprotein Receptor Knockout Mice Exhibit Exaggerated Microvascular Responses to Inflammatory Stimuli (1997)

The objective of this study was to determine whether genetically induced hypercholesterolemia affects leukocyte-endothelial cell interactions in postcapillary venules of the mouse cremaster muscle. Leukocyte adhesion, emigration, and other microvascular parameters were assessed in venules of normal (wild-type) and low-density lipoprotein receptor-deficient (LDLr-/-) mice maintained on either normal rodent chow or on a high cholesterol diet (HCD). Measurements were obtained under control conditions and after administration of either leukotriene B4 (LTB4), platelet-activating factor (PAF), or tumor necrosis factor-alpha (TNF-alpha). Elevated numbers of adherent and emigrated leukocytes were observed in venules of LDLr-/- (compared with wild-type) mice on HCD, both under baseline conditions and after exposure to either LTB4, PAF, or TNF-alpha. Plasma TNF-alpha levels were also elevated in LDLr-/- versus wild-type mice. Administration of blocking monoclonal antibodies demonstrated that intercellular adhesion molecule-1, but not vascular cell adhesion molecule-1, mediates the exaggerated leukocyte-endothelial cell adhesion observed in LDLr-/- mice. The results of these studies indicate that chronic hypercholesterolemia predisposes the microvasculature to intense leukocyte-endothelial cell adhesion in response to different inflammatory stimuli.
The proteolysis-inducing factor: in search of its clinical relevance in patients with metastatic gastric/esophageal cancer (2006)

The proteolysis-inducing factor is a putative mediator of cancer-associated weight loss. The goal of this study was to examine for the first time: (i) its prevalence in patients with metastatic gastric/esophageal cancer; and (ii) whether it possibly correlated with weight loss and anorexia and whether it predicted tumor response and patient survival. This study recruited 41 patients as part of a phase II therapeutic, chemotherapy protocol for patients with metastatic gastric/esophageal cancer. Patient eligibility criteria were designed to select a group of patients who would tolerate treatment with the drugs capecitabine and oxaliplatin. Urine for assaying the proteolysis-inducing factor was obtained at registration and then 6 weeks later. Patients completed the FACT-E questionnaire every 6 weeks and had their weights checked at the same interval. Patients were followed prospectively for tumor response and patient survival. Twenty-three (56%) patients had the proteolysis-inducing factor in their urine at registration, and 18 (64%) had it at 6 weeks. There was no statistically significant correlation between the presence of the proteolysis-inducing factor and weight loss or between its presence and anorexia. Moreover, there was no evidence that the presence of the proteolysis-inducing factor in urine was able to predict tumor response or patient survival. The proteolysis-inducing factor in urine does not appear to be tied to weight loss, anorexia, tumor response, or patient survival in the clinical setting of metastatic gastric/esophageal cancer.
A Novel Small Tapered Slot Antenna for Passive Imaging Sensors (2005)

We propose a compact planar antenna for a 94-GHz-band passive mm-wave (PMMW) imaging array system. The key feature is a parabolic tapered slot antenna structure with a center cut metal line that controls its radiation pattern and reduces the sidelobe level of the H-plane. By using this structure, we reduced the antenna size by one tenth compared to conventional tapered slot antennas, whereas the actual gain of this antenna was 12.4 dBi. In addition, this antenna has a circular radiation pattern. Therefore, it is suitable for a PMMW imaging array. We also present simple CPW-to-SLOT transitions with insertion loss of 0.5 dB between the 90 – 100GHz ranges.
MOLECULAR CLONING AND EXPRESSION OF A NEW ALPHA-1-ADRENERGIC RECEPTOR SUBTYPE (1990)

Departments of Anesthesiology, Medicine, and Biochemistry, Duke University Medical Center, Durham, NC 27710
Effect of bicarbonate on intracellular potential of rabbit ciliary epithelium (1992)

Extracellular HCO3- hyperpolarizes the intracellular potential and makes the aqueous medium negative with respect to the stromal surface of the rabbit ciliary epithelial syncytium. The bases for these observations have been unclear. We have been studying the bicarbonate-induced hyperpolarization (BIH) with sustained intracellular recordings for periods as long as 1-2 hrs. The BIH was observed [6.0 +/- 0.4 mV (mean +/- SE, N = 22)] even when the external pH was clamped constant by appropriately changing the CO2 tension. External HCO3- was required since aeration with CO2 at low external pH did not replicate the BIH. DIDS [4,4'-diisothiocyano-2,2'-disulfonic acid] did not abolish the effect. The hyperpolarization is unlikely to reflect the pH dependence of K+ channels alone, since the effect was not reduced by either 2 mM Ba2+ alone or 2 mM Ba2+ together with 50-100 microM quinidine. The BIH depends directly or indirectly on external Na+, since the sign of the polarization response was reversed either by replacing Na+ with N-methyl-D-glucamine or by blocking the Na+,K(+)-exchange pump with 50-100 microM ouabain. Replacement of external Cl- with NO3- or application of the Cl(-)channel blocker NPPB [5-nitro-2-(3-phenylpropylamino)-benzoate] depolarized the membrane and reversed the sign of the BIH. The response of the ciliary epithelium to HCO3- is complex and may arise from several mechanisms. We suggest that one important element is an anion channel whose conductance is reduced by bicarbonate and whose reversal potential is indirectly dependent on the operations of the Na+,K(+)-pump and a Cl(-)-linked symport.
A 0.85V Supply, High PSRR CMOS Voltage Reference without Resistor and Amplifier for Ultra-Low Power Applications (2021)

This paper presents an ultra-low power CMOS voltage reference (CVR) which is free of amplifier and resistor. A current generator circuit is used to generate a supply independent current to bias the active load in the temperature compensation circuit. Drain-source voltage of two critical MOSFETs is made equal in the current generator circuit by using a feedback arrangement to ensure a high PSRR of -75dB for the reference voltage. Temperature compensation is achieved by using the complementary to absolute temperature (CTAT) nature of gatesource of a MOSFET operating in the subthreshold region and proportional to absolute temperature (PTAT) nature of conventional composite pair architecture. The proposed CVR is designed in TSMC 180nm technology. The circuit works desirably for a supply range of 0.85V to 2.3V while generating a reference voltage of around 0.68V. Maximum temperature coefficient (TC) of 184 ppm/°C and minimum TC of 69 ppm/°C are noted for mismatch and process variations in the Monte-Carlo simulation for 1000 samples. The circuit consumes only 46nW of power, which makes it suitable for ultra-low power applications.
Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series (2015)

To increase kinase selectivity in an aminopyrazole-based PAK1 inhibitor series, analogues were designed to interact with the PAK1 deep-front pocket pre-DFG residue Thr-406, a residue that is hydrophobic in most kinases. This goal was achieved by installing lactam head groups to the aminopyrazole hinge binding moiety. The corresponding analogues represent the most kinase selective ATP-competitive Group I PAK inhibitors described to date. Hydrogen bonding with the Thr-406 side chain was demonstrated by X-ray crystallography, and inhibitory activities, particularly against kinases with hydrophobic pre-DFG residues, were mitigated. Leveraging hydrogen bonding side chain interactions with polar pre-DFG residues is unprecedented, and similar strategies should be applicable to other appropriate kinases.
Biologicals for Cancer Treatment: Monoclonal Antibodies (1985)

The use of monoclonal antibodies against human tumor cells is a theoretically highly attractive approach to cancer therapy. And technologically, the capability seems to be available. Problems such as defining the optimum antigens—and their antibodies—are currently being investigated intensively. Progress in this research and its clinical significance are reviewed.
Synthesis of a key derivative of glycosylphosphatidylinositol substances and synthesis of spacer glycosides for use in the formation of glycoconjugates and of self-assembled monolayer surfaces (1998)

The first chapter of this thesis describes glycosylation strategies for obtaining derivatives of 2-amino-2-deoxy-a-D-glucopyranosyl-(1-->6)-D-myo-inositol, a key building block for synthesis of ...
Tumor Neoantigens Derived from RNA Sequencing Analysis (2017)

Successful treatment of cancers with Immune Checkpoint Inhibitors (ICIs) has been associated with the mutational load of tumors. The biological rationale for this association between mutational load and ICI response is that neoantigens are generated by mutations in protein coding sequences that provide a steady flow of neoantigens to prime the immune system for the production of antigen-specific tumor-infiltrating lymphocytes (TILs). It is thought that mutant protein fragments will lead to altered MHC/peptide recognition and immune cell activation; ICI treatment enhances TIL functionality. Neoantigens are also relevant for an alternative, cell-based immunotherapeutic approach, i.e. Adoptive Cell Transfer (ACT). This concept of neoantigens derived from DNA mutations has led to an intense line of investigation to uncover relevant neoantigens. However, there has been mixed success with the current neoantigen discovery approach based on DNA mutation analysis of tumor samples by exome sequencing of genomic DNA. The current concept of neoantigens derived from mutant DNA ignores an alternative mechanism that can also generate neoantigens in cancers: Posttranscriptional editing of primary RNA. Here we propose to use full-length Single Molecule Real Time (SMRT) RNAseq to uncover pathologically edited mRNAs in cancers and complement the discovery of pathologic mRNA. We will discuss the respective algorithms and propose the combination with identification of candidate neoantigen peptides by mass spectrometry.
The Information Technology (IT) Industry in Bangalore (2019)

This chapter examines the causal reasons for Bangalore’s dominance in the Information Technology industry in India. It describes the urban competitiveness is defined as a process by which one urban area or one region dominates a particular economic activity more than other urban areas or regions in a geographical area. Studies related to urban competitiveness or territorial competition has largely been conducted in Western Europe and in North America. The economic liberalisation that is now taking place in many countries, including India, has increased the importance of the urban areas as recipients of Foreign Direct Investment. Economic determinants can be divided into factors of production, infrastructure, location, economic structure and urban amenities. The strategic determinants are mainly governmental effectiveness, urban strategy, institutional flexibility, and private-public sector co-operation. Urban amenities are those aspects of human society that can be realised only in cities, where there sufficient people to support a variety of services.