gebhart/patrepeval huggingface dataset:
A Functional Organic Battery (2007)

An organic battery was constructed using polymer P1, which contains a high density of pendant nitroxide radical functional groups. The reversible electrochemical formation of the oxoammonium cation from a nitroxide radical forms the basis of charge storage in this battery. To avoid dissolving the polymer in an electrolyte solution while fabricating the battery, a radical-compatible photocrosslinking strategy was developed using a bisazide photocrosslinker. Using this strategy, cathode-active films of P1 were produced and the resulting battery could be reversibly charged and discharged for up to 1000 cycles.
An adaptive MLSE receiver for TDMA systems: a hybrid of per-survivor processing and tentative decision MLSE (2003)

An adaptive maximum likelihood sequence estimation (MLSE) receiver employing both the per-survivor processing (PSP)-MLSE and the tentative decision (TD)-MLSE, and selecting either one of them depending on the received signal power is proposed. The received signal power is estimated by using a channel estimate, assuming that M-ary PSK symbols are transmitted. Simulation results demonstrate that the proposed MLSE can significantly reduce the computational complexity with little degradation in performance, as compared with the conventional PSP-MLSE.
Perceptual evaluation of dynamic cost weighting for unit selection TTS (2010)

Unit selection text-to-speech synthesis relies on multiple cost criteria, each encapsulating a different aspect of acoustic and prosodic context at any given concatenation point. For a particular set of criteria, the relative weighting of the resulting costs crucially affects final candidate ranking. We have recently advocated a new weighting strategy based on a data-driven framework separately optimized for each concatenation. In this approach, the cost distribution in every information stream is dynamically leveraged to locally shift weight towards those characteristics that prove most discriminative at this point. To further validate this procedure, this paper presents formal listening evidence suggesting that dynamic cost weighting indeed entails higher perceived TTS quality.
A novel low-loss modulation strategy for high-power bi-directional buck+boost converters (2007)

A novel low-loss, constant-frequency, zero-voltage-switching (ZVS) modulation strategy for bi-directional, cascaded, buck-boost DC/DC converters, used in a hybrid electrical vehicle (HEV), is presented and its benefits over state-of-the-art converters and soft-switching solutions are discussed in a comparative evaluation. To obtain ZVS with the purposed modulation strategy, the buck+boost inductance is selected and the switches are gated in a way that the inductor current has a negative offset current at the beginning and the end of each pulse period. This allows the MOSFET switches to turn on when the anti-parallel body diode is conducting. As the novel modulation strategy is a software-only solution, there are no additional expenses for active or passive components compared to conventional modulation implementations. Furthermore, an analytical and simulation investigation predicts an excellent efficiency over the complete operating range and a higher power density for a multi-phase converter equipped with the low-loss modulation. Experimental measurements performed with a converter prototype verify the mode of operation and the ZVS principle.
Anticorps monoclonaux ciblant le système immunitaire pour le traitement du lymphome (2010)

Des anticorps (Ac) monoclonaux ciblant le systeme immunitaire peuvent etre utilises pour stimuler la reponse immunitaire anti-tumorale. Nous avons evalue l'interet de ces Ac dits d'immunomodulation pour le traitement du lymphome. Nos resultats montrent que des Ac d'immunomodulation permettent d'augmenter la reponse immunitaire contre le lymphome dans plusieurs situations : (1) en association avec un vaccin therapeutique contre le lymphome, (2) en monotherapie, (3) en association avec l'Ac anti-CD20, rituximab. Parmi les differentes cibles d'immunomodulation testees, il semble que la molecule de costimulation CD137 (4-1BB) soit particulierement prometteuse pour le traitement du lymphome. Nous avons en effet montre qu'un Ac agoniste anti-CD137 avait une puissante action anti-lymphomateuse dans des modeles murins et pouvait induire une reponse immunitaire memoire capable de prevenir les rechutes. Grâce a une approche originale d'administration sequentielle, nous avons ainsi montre que l'Ac anti-CD137 permettait d'augmenter l'efficacite de l'Ac anti-CD20, rituximab. Ces resultats nous incitent a proposer un essai clinique evaluant un traitement par Ac anti-CD137 chez des patients atteints de lymphome, seul et/ou en association au rituximab. Ils fournissent egalement des pistes de reflexion quant au developpement futur d'Ac d'immunomodulation pour le traitement du lymphome.
Gamma ray mirror experimental campaign at INL's ZPPR facility. Preliminary report (2014)

Abstract not provided.
ChemInform Abstract: Organophosphorus‐Based Organic/Inorganic Hybrids (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High-speed addition/subtraction/complement/doubling of quaternary numbers using optical nonlinearities and DQPSK signals (2012)

We propose an innovative approach to implementing multiple arithmetic functions of quaternary numbers using optical nonlinearities and differential quadrature phase-shift keying (DQPSK) signals. By adopting 100 Gbit/s DQPSK signals (A, B) and exploiting nondegenerate four-wave mixing (FWM) for addition/subtraction and degenerate FWM for complement and doubling in a single highly nonlinear fiber, we demonstrate 50 Gbaud/s simultaneous quaternary addition (A+B), dual-directional subtraction (A-B, B-A), complement (-A, -B), and doubling (2B). Power penalties less than 4 dB (addition), 3 dB (dual-directional subtraction), 2 dB (complement), and 3.1 dB (doubling) are observed at a bit-error rate of 10(-9).
Role of insulin receptor substrate‐2 in interleukin‐9‐dependent proliferation (2000)

Interleukin-9 (IL-9) stimulation results in JAK, STAT and IRS1/2 phosphorylation. The role of IRS adaptor proteins in IL-9 signaling is not clear. We show that IL-9 induces IRS2 phosphorylation and association with phosphatidylinositol-3 kinase (PI 3-K) p85 subunit in TS1 cells and BaF/9R cells, which proliferate upon IL-9 stimulation. We observed a PI 3-K-dependent phosphorylation of protein kinase B (PKB) in TS1 cells, but not in BaF/9R, nor in other IL-9-dependent cell lines. Finally, 32D cells that were transfected with the IL-9 receptor but lack IRS expression survived in the presence of IL-9. Ectopic IRS1 expression allowed for IL-9-induced proliferation, in the absence of significant PKB phosphorylation.
The Nucleosomal Surface as a Docking Station for Kaposi's Sarcoma Herpesvirus LANA (2006)

Kaposi's sarcoma–associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) mediates viral genome attachment to mitotic chromosomes. We find that N-terminal LANA docks onto chromosomes by binding nucleosomes through the folded region of histones H2A-H2B. The same LANA residues were required for both H2A-H2B binding and chromosome association. Further, LANA did not bind Xenopus sperm chromatin, which is deficient in H2A-H2B; chromatin binding was rescued after assembly of nucleosomes containing H2A-H2B. We also describe the 2.9-angstrom crystal structure of a nucleosome complexed with the first 23 LANA amino acids. The LANA peptide forms a hairpin that interacts exclusively with an acidic H2A-H2B region that is implicated in the formation of higher order chromatin structure. Our findings present a paradigm for how nucleosomes may serve as binding platforms for viral and cellular proteins and reveal a previously unknown mechanism for KSHV latency.
Synthesis and antitrypanosomal activity of some bis(4-guanylphenyl) five- and six-membered ring heterocycles (1980)

2,5-Bis(4-guanylphenyl)-1,3-oxazole, 2,5-bis(4-guanylphenyl)-1,3,4-oxadiazole and -1,3,4-thiadiazole, and 3,6-bis(4-guanylphenyl)pyridazine and several of their "cyclic guanyl" analogues have been synthesized. 2,5-Bis(4-guanylphenyl)-1,3-oxazole and -1,3,4-thiadiazole showed good activity, whithout acute toxicity, against Trypanosoma rhodesiense in mice, producing cures at a 3 mg/kg dosage level. This activity is comparable to stilbamidine, hydroxystilbamidine, and pentamidine in this test. In contrast, 2,5-bis(4-guanylphenyl)-1,3,4-oxadiazole shows a sharp reduction in activity in our test system. Generally, the cyclic guanyl analogues exhibit low orders of activity, and toxicity begins to appear at moderate dosage levels. All guanyl and cyclic guanyl compounds were synthesized from bisnitrile precursors by way of imidate ester hydrochlorides in a classical Pinner-type approach.
Reliability Assessment of Through-Silicon Vias in Multi-Die Stack Packages (2012)

A thermo-mechanical reliability study of through-silicon vias (TSVs) is presented in this paper. TSVs are used to interconnect stacked dies to achieve 3-D packages. As the core of the TSV contains high coefficient of thermal expansion (CTE) copper surrounded by low-CTE SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and Si materials, the thermo-mechanical reliability of TSVs is a concern. When dies with such TSVs are stacked and packaged, the presence of additional structures and associated materials could introduce different thermo-mechanical concerns compared with free-standing wafers. This paper presents 3-D finite-element models for studying the thermo-mechanical stresses in TSVs in free-standing wafers and in stacked dies, which are packaged. Warpage measurements have been used to validate the finite-element modeling approach. The results from the finite-element models show that the TSV stresses in a packaging configuration are typically lower than the TSV stresses in a free-standing wafer configuration. In addition, it is seen that the microbumps connecting adjacent dies experience high magnitude of inelastic strain, indicating that such locations are of reliability concern.
Clinicopathological Features and Mutational Analysis of Patients with Aplastic Anemia and Hypoplastic Myelodysplastic Syndrome (2016)

Abstract Background: Pancytopenia and bone marrow aplasia/hypoplasia are caused by a heterogeneous group of disorders, most commonly aplastic anemia (AA), hypoplastic myelodysplastic syndrome (MDS), paroxysmal nocturnal hemoglobinuria (PNH), and T-cell large granular lymphocytosis (T-LGL). Clinical and morphological distinction among these entities is often challenging, particularly between AA and hypoplastic MDS. This study is to examine the clinicopathological and genetic features of a group of AA and hypoplastic MDS patients, with or without concurrent T-LGL and/or PNH, in order to better understand and differentiate the two entities. Methods and Materials: We retrieved 45 cases with cytopenias and hypoplastic bone marrow at Moffitt Cancer Center. Peripheral blood complete blood counts, bone marrow morphological findings, flow cytometric analyses for LGL and PNH, and cytogenetics data were extracted from electronic medical records. Targeted next-generation sequencing (54 myeloid neoplasm related genes) was performed on the bone marrow. Results: The 45 patients showed peripheral blood cytopenias and bone marrow aplasia or marked hypocellularity. There were 26 cases diagnosed with AA with no morphologic evidence of dysplasia or increased blasts in the bone marrow, and 19 cases diagnosed with hypoplastic MDS based on morphological and cytogenetic criteria. In the meantime, distinct T-LGL population was identified in 2 of 11 cases with AA (18.2%) and 3 of 11 cases with hypoplastic MDS (27.3%); PNH clones were identified in 8 of 17 cases with AA (47%) and 3 of 11 cases with hypoplastic MDS (27.3%). Clonal cytogenetic abnormalities were found in 2 of 25 cases with AA (8%) and 11 of 18 cases with hypoplastic MDS (61.1%). Twelve of 26 cases of AA (46%) showed one or more gene mutations with allele burden ranging from 7% to 52%, and most of these cases (9 of 12; 75%) involved only one gene. In contrast, 15 of 19 cases of hypoplastic MDS (78.9%) had one or more gene mutations with allele burden ranging from 19% to 53%. Seven of the 15 cases (46.7%) had two or more gene mutations. The most common mutated genes in the two groups in this study were ASXL1 and TET2. Conclusion: Although there are overlapping clinical and morphological features between AA and hypoplastic MDS, differences are present between the two entities including presence of PNH clones, cytogenetic changes, and gene mutation frequencies. These features may help to make differential diagnosis and identify the cases with more progression potential. Clinical outcomes with different treatment and larger scale studies are needed to better characterize and define the two different entities. Disclosures No relevant conflicts of interest to declare.
Unusually High Rate of Early Failure of Tibial Component in ATTUNE Total Knee Arthroplasty System at Implant–Cement Interface (2017)

Abstract A novel design total knee arthroplasty (TKA) system has been introduced to improve patient outcomes and increase longevity. However, we have encountered a high rate of debonding of tibial implant–cement interface. In addition, multiple reports have been filed in Manufacturer and User Facility Device Experience database (MAUDE) with the same mechanism of failure. Therefore, we evaluated: clinical, radiographic, and intraoperative findings of patients who received this system and required a revision surgery, and findings from MAUDE database compiled to this date. We reviewed three hospital databases for patients who had revision TKA for tibial loosening at the implant–cement interface. This yielded 15 cases with a mean age of 61 years (range, 47–84). All patients received a novel knee system at another institution. Radiographic analysis was performed by treating orthopaedist. The MAUDE database was reviewed for reports of aseptic failure. Patients presented with pain on weight bearing, effusion, and decreased range of motion (ROM) within 2 years after surgery. Radiographic evaluation demonstrated loosening of the tibial components in 2 of 15 knees. This included cruciate retaining, posterior stabilized, fixed bearing, and rotating platform bearing designs. Intraoperative findings demonstrated gross loosening of the tibial component at the implant–cement interface. Femoral and patellar components were well fixed. There were 21 reports of tibial loosening at the implant–cement interface in MAUDE database in the past 2 months alone. Numerous other tibial failures were reported; however, the mechanisms of failures were not specified. Tibial component loosening is a rare complication of cemented TKA at short-term follow-up. Several possible reasons include increased constraint, reduced cement pockets, and reduced keel rotational stabilizers. The tibial component, which has greater torsional loads, has lower surface roughness than femoral component. We believe that this complication is underreported due to failure of radiographs to assess loosening. In addition, MAUDE database reporting is not consistent and competing companies cannot provide data on the revised components. In patients who have negative workup for a painful joint, one must consider the diagnosis of debonding.
ODM-204: A novel dual inhibitor of CYP17A1 and androgen receptor for the treatment of castration-resistant prostate cancer—Preclinical data. (2015)

221 Background: Castration-resistant prostate cancer (CRPC) is characterized by high androgen receptor (AR) expression and persistent activation of AR signaling axis by residual tissue/tumor androgens. Targeting AR and androgen biosynthesis together may be more effective than either alone. ODM-204 is a novel, non-steroidal dual inhibitor of CYP17A1 and AR, which has shown promising results in preclinical studies. Methods: The binding affinity of ODM-204 to wild type AR was determined in rat prostate cytosolic lysates. The potency and functional activity of ODM-204 to human AR were demonstrated in cells stably transfected with the full-length AR and androgen-responsive reporter gene constructs. In addition, assays for AR nuclear translocation and the transactivation of human AR mutants T877A, W741L, and F876L were conducted. The effects of ODM-204 on the growth of androgen-dependent VCaP and LNCaP cells in vitro and subcutaneously grafted VCaP cells in vivo with the oral dose of 50 mg/kg/day were studied. The inhibition of CYP17A1 by ODM-204 was studied in vitro by using human and rat testicular microsomes and a human adrenal cortex cell line, and in vivo in male rats coadministered with luteinizing hormone releasing hormone agonist leuprolide acetate to mimic clinical situation. Results: ODM-204 is a potent inhibitor of both AR and CYP17A1. It binds to AR with a high affinity (Ki=47 nM) and selectivity and has a high potency towards CYP17A1 (IC 50 =22 nM). In addition, ODM-204 inhibited testosterone-mediated nuclear translocation of AR and the mutant ARs (IC 50 values for AR(T877A), AR(W741L), and AR(F876L) were 95, 277, and 6 nM, respectively), and suppressed androgen-induced cell proliferation of LNCaP (IC 50 =170 nM) and VCaP (IC 50 =280 nM) cells. In a VCaP xenograft model, ODM-204 showed significant antitumor activity (tumor growth inhibition=66%). In rats, inhibitory effects of leuprolide acetate on testosterone production and androgen-sensitive organ weights were potentiated by ODM-204. Conclusions: ODM-204 is a promising new dual CYP17A1 and AR inhibitor for the treatment of CRPC. Clinical trials in patients with mCRPC will be started in early 2015.
Validation of the Cancer BioChip System as a 3D siRNA Screening Tool for Breast Cancer Targets (2012)

Genomic studies have revealed that breast cancer consists of a complex biological process with patient-specific genetic variations, revealing the need for individualized cancer diagnostic testing and selection of patient-specific optimal therapies. One of the bottlenecks in translation of genomic breakthroughs to the clinic is the lack of functional genomic assays that have high clinical translatability. Anchorage-independent three-dimensional (3D) growth assays are considered to be the gold-standard for chemosensitivity testing, and leads identified with these assays have high probability of clinical success. The Cancer BioChip System (CBCS) allows for the simultaneous, quantitative, and real time evaluation of multitudes of anchorage-independent breast cancer cell growth inhibitors. We employed a Test Cancer BioChip that contains silencing RNAs (siRNAs) targeting cancer-related genes to identify 3D-specific effectors of breast cancer cell growth. We compared the effect of these siRNAs on colony growth of the hormone receptor positive (MCF7) and Human Epidermal Growth Factor Receptor 2/c- Erythroblastic Leukemia Viral Oncogene Homolog 2 (HER2/c-erb-b2) positive (SK-BR-3) cells on the Test Cancer BioChip. Our results confirmed cell-specific inhibition of MCF7 and SK-BR-3 colony formation by estrogen receptor α (ESR1) and (ERBB2) siRNA, respectively. Both cell lines were also suppressed by Phosphoinositide-3-kinase Catalytic, alpha Polypeptide (PIK3CA) siRNA. Interestingly, we have observed responses to siRNA that are unique to this 3D setting. For example, ß-actin (ACTB) siRNA suppressed colony growth in both cell types while Cathepsin L2 (CTSL2) siRNA caused opposite effects. These results further validate the importance of the CBCS as a tool for the identification of clinically relevant breast cancer targets.
Splitting matter waves using an optimized standing-wave light-pulse sequence (2005)

In a recent experiment (Wang et al., e-print cond-mat/0407689), it was observed that a sequence of two standing-wave square pulses can split a Bose-Einstein Condensate at rest into $\ifmmode\pm\else\textpm\fi{}2\ensuremath{\hbar}\mathbf{k}$ diffraction orders with almost 100% efficiency. By truncating the Raman-Nath equations to a two-state model, we provide an intuitive picture that explains this double-square-pulse beam-splitter scheme. We further show it is possible to optimize a standing-wave multiple-square-pulse sequence to efficiently diffract an atom at rest to a symmetric superposition of $\ifmmode\pm\else\textpm\fi{}2n\ensuremath{\hbar}\mathbf{k}$ diffraction orders with $n&gt;1$. The approach is considered to be qualitatively different from the traditional light-pulse schemes in the Bragg or the Raman-Nath region, and can be extended to more complex atomic optical elements that produce various tailored output momentum states from a cold atom source.
Application-aware resource management in wireless and visual sensor networks (2008)

during the winter of 2006. Her primary research interests lie in the area of wireless communication and networking, wireless sensor networks, and visual (camera-based) networks. ii Acknowledgements During the last five years I had the pleasure to work in the Wireless Lab. Among all the wonderful people I met during this period, I would first like to thank to my advisor, Professor Wendi Heinzelman for the guidance and encouragement she provided. I learned many lessons from her, but the most important were to be enthusiastic about my work and life, and to be persistent. Her intelligence, great life attitude and passion for research truly inspired me. I would also like to thank to Professor Mark Bocko for his generous support at the times I needed help most. My cordial thanks extend to Professor Gaurav Sharma on his collaboration and to Professor Kai Shen and Professor Lane Hemaspaandra for being on my dissertation defense committee. I would like to thank to all members of the Sensors group at the University of Rochester for their
An evaluation tool for FKBP12-dependent and -independent mTOR inhibitors using a combination of FKBP-mTOR fusion protein, DSC and NMR (2011)

Mammalian target of rapamycin (mTOR), a large multidomain protein kinase, regulates cell growth and metabolism in response to environmental signals. The FKBP rapamycin-binding (FRB) domain of mTOR is a validated therapeutic target for the development of immunosuppressant and anticancer drugs but is labile and insoluble. Here we designed a fusion protein between FKBP12 and the FRB domain of mTOR. The fusion protein was successfully expressed in Escherichia coli as a soluble form, and was purified by a simple two-step chromatographic procedure. The fusion protein exhibited increased solubility and stability compared with the isolated FRB domain, and facilitated the analysis of rapamycin and FK506 binding using differential scanning calorimetry (DSC) and solution nuclear magnetic resonance (NMR). DSC enabled the rapid observation of protein-drug interactions at the domain level, while NMR gave insights into the protein-drug interactions at the residue level. The use of the FKBP12-FRB fusion protein combined with DSC and NMR provides a useful tool for the efficient screening of FKBP12-dependent as well as -independent inhibitors of the mTOR FRB domain.