gebhart/patrepeval huggingface dataset:
Evaluating Overall Survival and Competing Risks of Death in Patients With Localized Renal Cell Carcinoma Using a Comprehensive Nomogram (2009)

Management of localized RCC must consider competing causes of mortality, particularly in elderly populations. Effective decision making requires treatment trade-off calculations. We present a tool to quantitate competing causes of mortality in patients with localized RCC.
In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis (2021)

Transthyretin (TTR) proteolysis has been recognized as a complementary mechanism contributing to transthyretin-related amyloidosis (ATTR amyloidosis). Accordingly, amyloid deposits can be composed mainly of full-length TTR or contain a mixture of both cleaved and full-length TTR, particularly in the heart. The fragmentation pattern at Lys48 suggests the involvement of a serine protease, such as plasmin. The most common TTR variant, TTR V30M, is susceptible to plasmin-mediated proteolysis, and the presence of TTR fragments facilitates TTR amyloidogenesis. Recent studies revealed that the serine protease inhibitor, SerpinA1, was differentially expressed in hepatocyte-like cells (HLCs) from ATTR patients. In this work, we evaluated the effects of SerpinA1 on in vitro and in vivo modulation of TTR V30M proteolysis, aggregation, and deposition. We found that plasmin-mediated TTR proteolysis and aggregation are partially inhibited by SerpinA1. Furthermore, in vivo downregulation of SerpinA1 increased TTR levels in mice plasma and deposition in the cardiac tissue of older animals. The presence of TTR fragments was observed in the heart of young and old mice but not in other tissues following SerpinA1 knockdown. Increased proteolytic activity, particularly plasmin activity, was detected in mice plasmas. Overall, our results indicate that SerpinA1 modulates TTR proteolysis and aggregation in vitro and in vivo.
Synthetic Siglec-9 Agonists Inhibit Neutrophil Activation Associated with COVID-19 (2020)

Severe cases of coronavirus disease 2019 (COVID-19), caused by infection with SARS-Cov-2, are characterized by a hyperinflammatory immune response that leads to numerous complications. Production of proinflammatory neutrophil extracellular traps (NETs) has been suggested to be a key factor in inducing a hyperinflammatory signaling cascade, allegedly causing both pulmonary tissue damage and peripheral inflammation. Accordingly, therapeutic blockage of neutrophil activation and NETosis, the cell death pathway accompanying NET formation, could limit respiratory damage and death from severe COVID-19. Here, we demonstrate that synthetic glycopolymers that activate the neutrophil checkpoint receptor Siglec-9 suppress NETosis induced by agonists of viral toll-like receptors (TLRs) and plasma from patients with severe COVID-19. Thus, Siglec-9 agonism is a promising therapeutic strategy to curb neutrophilic hyperinflammation in COVID-19.
The structure of charoite, (K,Sr,Ba,Mn)15–16(Ca,Na)32[(Si70(O,OH)180)](OH,F)4.0.nH2O, solved by conventional and automated electron diffraction (2010)

Abstract Charoite, ideally (K,Sr,Ba,Mn) 15–16 (Ca,Na) 32 [(Si 70 (O,OH) 180 )](OH,F) 4.0 · n H 2 O, a rare mineral from the Murun massif in Yakutiya, Russia, was studied using high-resolution transmission electron microscopy, selected-area electron diffraction, X-ray spectroscopy, precession electron diffraction and the newly developed technique of automated electron-diffraction tomography. The structure of charoite ( a = 31.96(6) Å, b = 19.64(4) Å, c = 7.09(1) Å, β = 90.0(1)°, V = 4450(24) Å 3 , space group P 2 1 / m ) was solved ab initio by direct methods from 2878 unique observed reflections and refined to R 1 / wR 2 = 0.17/0.21. The structure can be visualized as being composed of three different dreier silicate chains: a double dreier chain, [Si 6 O 17 ] 10– ; a tubular loop-branched dreier triple chain, [Si 12 O 30 ] 12– ; and a tubular hybrid dreier quadruple chain, [Si 17 O 43 ] 18– . The silicate chains occur between ribbons of edge-sharing Ca and Na-octahedra. The chains of tetrahedra and the ribbons of octahedra extend parallel to the z axis. K + , Ba 2+ , Sr 2+ , Mn 2+ and H 2 O molecules lie inside tubes and channels of the structure. On the basis of microprobe analyses and occupancy refinement of the cation sites, the crystal chemical formula of this charoite can be written as ( Z = 1): (K 13.88 Sr 1.0 Ba 0.32 Mn 0.36 ) Σ15.56 (Ca 25.64 Na 6.36 ) Σ32 [(Si 6 O 11 (O,OH) 6 ) 2 (Si 12 O 18 (O,OH) 12 ) 2 (Si 17 O 25 (O,OH) 18 ) 2 ](OH,F) 4.0 ·3.18H 2 O.
MCRB-based Performance Analysis of 6G Localization under Hardware Impairments (2022)

Location information is expected to be the key to meeting the needs of communication and context-aware services in 6G systems. User localization is achieved based on delay and/or angle estimation using uplink or downlink pilot signals. However, hardware impairments (HWIs) distort the signals at both the transmitter and receiver sides and thus affect the localization performance. While this impact can be ignored at lower frequencies where HWIs are less severe, modeling and analysis efforts are needed for 6G to evaluate the localization degradation due to HWIs. In this work, we model various types of impairments and conduct a misspecified Cramér-Rao bound analysis to evaluate the HWI-induced performance loss. Simulation results with different types of HWIs show that each HWI leads to a different level of degradation in angle and delay estimation performance.
Research on a Lange Change Intent Inference Based on Driver Model With Cognitive Scientific Validity (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
An Access Control System for Web Service Compositions (2007)

Service composition has emerged as a fundamental technique for developing Web applications. Multiple services, often from different organizations or trust domains, may be dynamically composed to satisfy a user's request. Access control in the presence of service compositions is a challenging security problem. In this paper, we present an access control model and techniques for specifying and enforcing access control rules on Web service compositions. A key advantage of our approach is that past histories of service invocations can be used to make access control decisions. Our approach allows role hierarchies and separation of duty constraints. Access controls rules may be parameterized by one or more arguments. We have implemented our access control model via a declarative policy specification language which uses pure-past linear temporal logic (PPLTL). We describe an implementation of our approach using a supply chain management (SCM) application. Our experiments show that our approach can enforce expressive and flexible access control policies while incurring reasonable performance overhead on the application.
Fast data analytics with FPGAs (2011)

The rapidly increasing amount of data available for real-time analysis (i.e., so-called operational business intelligence) is creating an interesting opportunity for creative approaches to speeding up data processing algorithms. One such approach that is starting to become more common is using hardware accelerators for stream processing. Typically these accelerators are implemented on top of reconfigurable hardware, known as field-programmable gate arrays (FPGAs). Though the value of FPGAs for data warehouses is gradually recognized by the database community, their true potential for various business analytic tasks is yet unexplored. In this line of research, we investigate FPGA technology in the context of extreme data processing looking for opportunities where FPGAs can be exploited to improve over classical CPU-based architectures. We introduce a framework for FPGA-accelerated (real-time) analytics including a query-to-hardware compiler for static complex event detection, an XPath engine for dynamic query workloads, and templates for high-speed data mining operators in hardware.
DeCorus-NSA (2021)

The management of large data centre (DC) network infrastructure confronts Network Reliability Engineers (NRE) with challenges. A single DC at a modern cloud services provider can host thousands of network devices. The syslog messages generated by these devices are an important type of monitoring data to detect and diagnose failures. Devices in a single DC produce millions of syslog messages per day in a variety of formats.
Video Based Cocktail Causal Container for Blood Pressure Classification and Blood Glucose Prediction (2022)

With the development of modern cameras, more physiological signals can be obtained from portable devices like smartphone. Some hemodynamically based non-invasive video processing applications have been applied for blood pressure classification and blood glucose prediction objectives for unobtrusive physiological monitoring at home. However, this approach is still under development with very few publications. In this paper, we propose an end-to-end framework, entitled cocktail causal container, to fuse multiple physiological representations and to reconstruct the correlation between frequency and temporal information during multi-task learning. Cocktail causal container processes hematologic reflex information to classify blood pressure and blood glucose. Since the learning of discriminative features from video physiological representations is quite challenging, we propose a token feature fusion block to fuse the multi-view fine-grained representations to a union discrete frequency space. A causal net is used to analyze the fused higher-order information, so that the framework can be enforced to disentangle the latent factors into the related endogenous association that corresponds to down-stream fusion information to improve the semantic interpretation. Moreover, a pair-wise temporal frequency map is developed to provide valuable insights into extraction of salient photoplethysmograph (PPG) information from fingertip videos obtained by a standard smartphone camera. Extensive comparisons have been implemented for the validation of cocktail causal container using a Clinical dataset and PPG-BP benchmark. The root mean square error of 1.329±0.167 for blood glucose prediction and precision of 0.89±0.03 for blood pressure classification are achieved in Clinical dataset.
Discovery of N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a Potent and Orally Bioavailable CFTR Potentiator (2014)

Quinolinone-3-carboxamide 1, a novel CFTR potentiator, was discovered using high-throughput screening in NIH-3T3 cells expressing the F508del-CFTR mutation. Extensive medicinal chemistry and iterative structure-activity relationship (SAR) studies to evaluate potency, selectivity, and pharmacokinetic properties resulted in the identification of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, 48, ivacaftor), an investigational drug candidate approved by the FDA for the treatment of CF patients 6 years of age and older carrying the G551D mutation.
Rover: scalable location-aware computing (2002)

All the components necessary for realizing location-aware computing are available in the marketplace today. What has hindered the widespread deployment of location-based systems is the lack of an integration architecture that scales with user populations. The authors have completed the initial implementation of Rover, a system designed to achieve this sort of integration and to automatically tailor information and services to a mobile user's location. Their studies have validated Rover's underlying software architecture, which achieves system scalability through high-resolution, application-specific resource scheduling at the servers and network. The authors believe that this technology will greatly enhance the user experience in many places, including museums, amusement and theme parks, shopping malls, game fields, offices, and business centers. They designed the system specifically to scale to large user populations and expect its benefits to increase with them.
mGlu5 Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu5-Endocannabinoid Signaling (2019)

Metabotropic glutamate (mGlu) receptor type 5 (mGlu<sub>5</sub>) positive allosteric modulators (PAMs) enhance hippocampal long-term potentiation (LTP) and have cognition-enhancing effects in animal models. These effects were initially thought to be mediated by potentiation of mGlu<sub>5</sub> modulation of <i>N</i>-methyl-d-aspartate receptor (NMDAR) currents. However, a biased mGlu<sub>5</sub> PAM that potentiates Gα<sub>q</sub>-dependent mGlu<sub>5</sub> signaling, but not mGlu<sub>5</sub> modulation of NMDAR currents, retains cognition-enhancing effects in animal models, suggesting that potentiation of NMDAR currents is not required for these <i>in vivo</i> effects of mGlu<sub>5</sub> PAMs. However, it is not clear whether the potentiation of NMDAR currents is critical for the ability of mGlu<sub>5</sub> PAMs to enhance hippocampal LTP. We now report the characterization of effects of two structurally distinct mGlu<sub>5</sub> PAMs, VU-29 and VU0092273, on NMDAR currents and hippocampal LTP. As with other mGlu<sub>5</sub> PAMs that do not display observable bias for potentiation of NMDAR currents, VU0092273 enhanced both mGlu<sub>5</sub> modulation of NMDAR currents and induction of LTP at the hippocampal Schaffer collateral (SC)-CA1 synapse. In contrast, VU-29 did not potentiate mGlu<sub>5</sub> modulation of NMDAR currents but induced robust potentiation of hippocampal LTP. Interestingly, both VU-29 and VU0092273 suppressed evoked inhibitory postsynaptic currents (eIPSCs) in CA1 pyramidal cells, and this effect was blocked by the cannabinoid receptor type 1 (CB1) antagonist AM251. Furthermore, AM251 blocked the ability of both mGlu<sub>5</sub> PAMs to enhance LTP. Finally, both PAMs failed to enhance LTP in mice with the restricted genetic deletion of mGlu<sub>5</sub> in CA1 pyramidal cells. Taken together with previous findings, these results suggest that enhancement of LTP by mGlu<sub>5</sub> PAMs does not depend on mGlu<sub>5</sub> modulation of NMDAR currents but is mediated by a previously established mechanism in which mGlu<sub>5</sub> in CA1 pyramidal cells induces endocannabinoid release and CB1-dependent disinhibition.
Detecting Important Intermediates in Pd Catalyzed Depolymerization of a Lignin Model Compound by a Combination of DFT Calculations and Constrained Minima Hopping (2016)

Density functional theory (DFT) calculations, combined with a constrained minima hopping algorithm (global minimum search while preserving the molecular identity), have been performed to investigate important reaction intermediates for the heterogeneously catalyzed β-O-4′ bond cleavage in lignin derivatives. More specifically, we have studied the adsorption properties of a keto tautomer (1-methoxypropan-2-one) and its enol form on a catalytically active Pd(111) surface. In agreement with experiments, we find that for the gas-phase molecules the keto tautomer is the most stable. Interestingly, the enol tautomer has a higher affinity to the Pd catalyst than the keto form, and becomes the most stable molecular form when adsorbed on the catalyst surface. The global minimum complex found on the metal surface corresponds to an enolate structure formed when the enol tautomer chemisorbs onto the surface and donates its π-electrons from the C═C region to two adjacent palladium atoms. The actual formation of a chemical bond to the surface in the case of the enol molecule could be the key to understanding why the enol derivative is needed for an efficient β-O-4′ bond cleavage.
Cell Surfaces in Plant-Microorganism Interactions (1984)

The production of ethylene by melon (Cucumis melo cv Cantaloup charentais) tissues is stimulated during incubation in the presence of fungal glycopeptides extracted from Colletotrichum lagenarium, a pathogen of melon. These glycopeptides, called elicitors of ethylene, are found in the mycelium, the cell wall, and the culture filtrate. Elicitation of ethylene is a relatively early phenomenon and lasts for several hours. Upon purification of the crude elicitor extract by gel filtration and ion exchange chromatography, three elicitors were isolated. The three elicitors contained amino acid, sugar, and phosphate residues, and they have a decreased activity after partial chemical degradation of their sugar moiety.Elicitation of ethylene is not fungal species specific. Elicitors of phytoalexins, obtained from three Phytophtora species, enhanced ethylene biosynthesis in melon tissues.
Nanobody-based universal histone binding domains for chromatin imaging and editing (2014)

National audience
Clonal hematopoiesis: the nonhereditary genetics of age-associated cardiovascular disease (2023)

Accumulating evidence shows that clonal hematopoiesis represents a new mechanism for cardiovascular disease and a new risk factor that is as prevalent and consequential as the traditional risk factors that have been studied for decades.
Low threshold current CW operation of GaInAsP/InP buried heterostructure distributed Bragg-reflector integrated-twin-guide laser emitting at 1.5–1.6 μm (1981)

Low threshold current CW operation of a 1.5–1.6 μm-wavelength GaInAsP/InP buried heterostructure distributed Bragg reflector integrated twin guide (BH-DBR-ITG) laser was obtained up to 12°C. Single wavelength operation was obtained at a temperature range of 25 deg. The temperature dependence of lasing wavelength was 0.10 nm/deg. At 248 K, the threshold current, the differential quantum efficiency and the maximum output power were 37 mA, 16.3%/facet and 6 mW, respectively.
Collapsible Wind Powered Energy Generation and Storage Device (2015)

The described research is a light weight, inexpensive portable and collapsible wind turbine, small enough to be carried in a backpack, ruck sack or within the storage compartment of a vehicle, which can be used to recharge batteries and provide off-site, emergency, or campsite power. As a means to extend the battery life of electronic equipment while moving away from the power grid and extra battery storage, a power generating unit is needed. Current approaches are to carry the anticipated number of spare batteries, to use solar cells or any number of small generating thermionic devices. While each of these have a place in the market, they also have negative cost, size, and weight drawbacks. The objective of this research is to create a power generating/storage wind turbine device for recreational, emergency, and military use that can easily be collapsed and transported as needed. The device is a lightweight, collapsible wind turbine constructed of rugged materials to be used on camp sites, remote locations etc. and carried within a pack for travel. It is of a size and weight to be part of an emergency or survival pack. The wind turbine, in its preferred embodiment, is a self-starting/sustaining device that starts at low wind speeds so no monitoring or priming of the device is necessary. In addition to the novelty of it being collapsible, the wind turbine device employs advanced features to increase its wind energy capture efficiency and its energy storage and delivery system, along with unique design features that make it rugged, lightweight and easily assembled.
The Electromechanical Properties of SEBS and SEBS-g-MA Dielectric Elastomer Gels (2010)

Electromechanical strain responses of a poly (styrene-b-ethylene-co-butylene-b-styrene) (SEBS) and a maleic anhydride grafted poly (styrene-b-ethylene-co-butylene-b-styrene) (SEBS-g-MA) dielectric elastomer gels have been investigated via an in-situ synchrotron SAXS. The gels had the periodic nanostructures where there was glassy styrene micelles acting as physical crosslink points in the oil swelled rubbery EB matrix. The electromechanical strain of the gel was evaluated from its nanostructure dimension change monitored by the synchrotron SAXS during the electromechanical actuation. The strain was increased with electric field strength. The SEBS-g-MA gel had the higher electromechanical strain response than the SEBS gel at the same electric field.
Drone-Assisted Communications for Remote Areas and Disaster Relief (2019)

We explore an end-to-end (including access and backhaul links) UAV-assisted wireless communication system, considering both uplink and downlink traffics, with the goal of supporting demand of the Ground Users (GUs) using the minimum number of UAVs. Moreover, in order to extend the operational (flight) time of UAVs, we exploit an energy-aware routing scheme. Our intention is to design and analyze the access and backhaul connectivity of a drone-assisted communication network for remote and crowded areas and disaster relief, while minimizing the resources required i.e., the number of UAVs.
Retinal Signs and Stroke (2008)

Background and Purpose— The retinal and cerebral vasculature share similar anatomic, physiological, and embryological characteristics. We reviewed the literature, focusing particularly on recent population-based studies, to examine the relationship between retinal signs and stroke. Summary of Review— Hypertensive retinopathy signs (eg, focal retinal arteriolar narrowing, arterio-venous nicking) were associated with prevalent stroke, incident stroke, and stroke mortality, independent of blood pressure and other cerebrovascular risk factors. Diabetic retinopathy signs (eg, microaneurysms, hard exudates) were similarly associated with incident stroke and stroke mortality. Retinal arteriolar emboli were associated with stroke mortality but not incident stroke. There were fewer studies on the association of other retinal signs such as retinal vein occlusion and age-related macular degeneration with stroke, and the results were less consistent. Conclusion— Many retinal conditions are associated with stroke, reflecting possible concomitant pathophysiological processes affecting both the eye and the brain. However, the incremental value of a retinal examination for prediction of future stroke risk remains to be determined.
Decay Dynamics and Quenching of Photoluminescence from Silicon Nanocrystals by Aromatic Nitro Compounds (2000)

The decay dynamics and the quenching of the photoluminescence (PL) from Si nanocrystals are investigated. Electron acceptors whose reduction potentials lie below the conduction band (CB) edge of the Si nanocrystals quench the red emission from the Si nanocrystals. The quenching rate constants obtained from Stern−Volmer analyses for 3,5-dinitrobenzonitrile, 4-nitrophthalonitrile, 1,4-dinitrobenzene, 4-nitrobenzonitrile, 2,3-dinitrotoluene, 3,4-dinitrotoluene, 2,4-dinitrotoluene, and 2,6-dinitrotoluene are in the range of 106−107 M-1 s-1. The quenching mechanism occurs via an electron transfer from the CB band of the Si nanocrystals to the vacant orbitals of the quenchers. The PL decay profiles of the Si nanocrystals, in the presence and absence of the quencher, are well described by the stretched exponential decay law. The band gap of the Si nanocrystals estimated from the present study is larger than the PL peak energy. The results are consistent with a quantum-confinement model, where recombination of electrons and holes occurs in a surface state. The ability of nitrotoluenes to quench the PL from Si nanocrystals could be used to develop a sensor based on Si nanostructures for the detection of explosives.
Supplementary Figure 14 from Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer (2023)

&lt;p&gt;Patients who experienced local recurrence only after treatment for early stage breast cancer. cfDNA time points for all patients who experienced local recurrence only. End points represent time of last follow up or death.&lt;/p&gt;