gebhart/patrepeval huggingface dataset:
Optimizing Drilling Operations in the Arkoma Basin: Building on Success (2006)

Abstract The Red Oak Field is located in the Arkoma Basin in Southeastern Oklahoma. The Field recently exceeded peak production levels in what was previously deemed a fully developed reservoir, through an ongoing successful infill drilling program based on the use of three-dimensional (3-D) seismic. Moreover, the redevelopment program has surpassed the 100 well mark and has delivered some high rate gas wells. The field may be characterized by its dry gas and multiple pay horizons in what has long been known to be "crookedhole country". In situ compressive strengths range from 10,000-psia through the Pennsylvanian to 55,000-psia through the Ordovician. Much work has been done in the past to optimize air drilling operations for shallow wells; however, as deeper horizons are exploited new technologies have been implemented in order to deliver continuous improvement. Drilling improvements in recent years have included the introduction of a state-of-the-art drilling rig, further optimization of air drilling operations and the introduction of Polycrystalline Diamond Compact (PDC) bits. A down-hole vibration mitigation effort was also initiated which yielded improved bit runs and the identification of micro-tortuosity and weight transfer issues. Vibration mitigation resulted in the redesign of bottom hole assemblies (BHA) and the optimization of bent-housing steerable-motor angle settings. Rig rates have increased over time, along with the need for designer wells. Rotary Steerable Systems (RSS) were therefore implemented to address these issues. Initial attempts indicated that RSS were not able to overcome the formation tendencies in 3-D space. A detailed investigation resulted in the hypothesis whereby speeding up the RSS with a motor would provide enough side force with a push-the-bit system to overcome formation tendencies. Real-time Mechanical Specific Energy (MSE) measurements were used in conjunction with the implementation of a Powered Rotary Steerable Systems (PRSS) and revealed the fact that the full benefit of the RSS was not consistently realized (mostly due to the extreme nature of the drilling environment). As such, prototype extended-gauge PDC bits were designed in order to further reduce down-hole vibration, improve well bore quality and bit performance. The result has been sustained top quartile performance, a state drilling record and the continued growth of a mature field.
Entlassung von Patienten mit Demenz und kognitiven Defiziten aus dem Krankenhaus (2014)

Im Zuge des demographischen Wandels erwarten wir eine deutliche Zunahme der absoluten Anzahl der an Demenz, oder anderen hirnorganischen Erkrankungen mit einer pathologisch eingeschränkten kognitiven Funktion (im restlichen Text als kognitive Defizite zusammengefasst), betroffenen Menschen in der Gesellschaft. Dieser Wandel wird sich auch zwangsläufig in der Zusammensetzung der Patienten in den Akutkrankenhäusern widerspiegeln. Aktuell führen wir eine deskriptive Studie an der Uniklinik Gießen und Marburg (Standort Gießen) durch, bei der wir Patienten mit kognitiven Defiziten, oder stellvertretend deren gesetzliche Betreuer, bezüglich ihrer momentanen Lebenssituation befragen und dabei mögliche Schwierigkeiten in der Versorgung ergründen. Die Befragung findet zu vier unterschiedliche Zeitpunkten (nach Aufnahme in der Uniklinik Gießen, kurz vor der Entlassung, eine Woche nach der Entlassung, und vier Wochen nach der Entlassung) statt. Ziel ist es, die aktuelle Situation bezüglich der Krankenhausentlassung von Patienten mit kognitiven Defiziten zu erfassen.
Molecular Mimicry in Innate Immunity (2009)

Macrophages detect pathogen infection via the activation of their plasma membrane-bound Toll-like receptor proteins (TLRs). The heterotypic interaction between the Toll/interleukin-1 receptor (TIR) domains of TLRs and adaptor proteins, like Myeloid differentiation primary response gene 88 (MyD88), is the first intracellular step in the signaling pathway of the mammalian innate immune response. The hetero-oligomerization of the TIRs of the receptor and adaptor brings about the activation of the transcription factor NF-kappaB, which regulates the synthesis of pro-inflammatory cytokines. Here, we report the first crystal structure of a bacterial TIR domain solved at 2.5 A resolution. The three-dimensional fold of Paracoccus denitrificans TIR is identical to that observed for the TIR of human TLRs and MyD88 proteins. The structure shows a unique dimerization interface involving the DD-loop and EE-loop residues, whereas leaving the BB-loop highly exposed. Peptide amide hydrogen-deuterium exchange mass spectrometry also reveals that the same region is used for dimerization in solution and in the context of the full-length protein. These results, together with a functional interaction between P. denitrificans TIR and MyD88 visualized in a co-immunoprecipitation assay, further substantiate the model that bacterial TIR proteins adopt structural mimicry of the host active receptor TIR domains to interfere with the signaling of TLRs and their adaptors to decrease the inflammatory response.
Simulation Based Assessment of Plug-in Hybrid Electric Vehicle Behavior During Real-World 24-Hour Missions (2010)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;This paper proposes a simulation based methodology to assess plug-in hybrid vehicle (PHEV) behavior over 24-hour periods. Several representative 24-hour missions comprise naturalistic cycle data and information about vehicle resting time. The data were acquired during Filed Operational Tests (FOT) of a fleet of passenger vehicles carried out by the University of Michigan Transportation Research Institute (UMTRI) for safety research. Then, PHEV behavior is investigated using a simulation with two different charging scenarios: (1) Charging overnight; (2) Charging whenever possible. Charging/discharging patterns of the battery as well as trends of charge depleting (CD) and charge sustaining (CS) modes at each scenario were assessed. Series PHEV simulation is generated using Powertrain System Analysis Toolkit (PSAT) developed by Argonne National Laboratory (ANL) and in-house Matlab codes. Certification driving cycles, such as UDDS, HWFET, and US06, have been used in most previous research of PHEVs. Our results indicate very different instantaneous loads with naturalistic driving schedules. In particular, the required power of the motor frequently reached the maximum (120 kW), thus, the battery must be capable of supplying at least 134 kW power. In severe cases, the battery SOC dropped so fast to the lower limit (0.4) that the driving mode changed from the CD mode to the CS mode before the end of a one-way trip. Detailed time history of the battery SOC and current is predicted for the aggressive real-world driving conditions. This information provides valuable input for PHEV design optimization, battery health studies, assessment of real-world all electric range (AER) and charging schedules.&lt;/div&gt;&lt;/div&gt;
Preliminary properties of a resin from ethynyl terminated materials (1991)

A blend composed of an ethynyl terminated aspartimide (brittle component) and an ethynyl terminated arylene ether oligomer (tough component) was thermally cured to yield a resin which underwent preliminary evaluation to determine the potential for use in structural applications on aerospace vehicles. The blend exhibited good compression moldability, allowing for fabrication of neat moldings, adhesive specimens and composites at temperatures of 250 C under a pressure of 1.4 MPa (200 psi). Neat resin moldings and adhesive specimens provided relatively high mechanical properties. Composite specimens provided promising results in spite of fiber misalignment, fiber washout, and a small amount of panel warpage.
Characterization of Intrinsic Hydrogenated Amorphous Si1-xOx Layers for High Efficiency Heterojunction Si Solar Cells (2011)

Intrinsic hydrogenated amorphous Si1-xOx (i-a-Si1-xOx:H ) layers show good passivation properties because a formation of defective epitaxial layers is suppressed at the interface of amorphous silicon / crystalline silicon even at a high temperature exceeding 200°C. Hence, the improvement of open-circuit voltage is expected using the i-a-Si1-xOx:H layers as the surface passivation layers of n-type Si heterojunction solar cells. In this research, the effects of the CO2/SiH4 ratio, the substrate temperature, and the annealing on the passivation properties are investigated by means of a minority carrier lifetime measurement and Fourier-transform infrared (FTIR) spectroscopy. To obtain the high quality i-a-Si1-xOx:H layers, the substrate temperature should be high enough because the defective Si-H2 bonds are less. Furthermore, the passivation quality as well as the layer quality improves so much by the combination of introducing H2 dilution and annealing even at a low temperature.
Mathematical Modeling Research to Support the Development of Automated Insulin-Delivery Systems (2009)

One year after its initial meeting, the Glycemia Modeling Working Group reconvened during the 2009 Diabetes Technology Meeting in San Francisco, CA. The discussion, involving 39 scientists, again focused on the need for individual investigators to have access to the clinical data required to develop and refine models of glucose metabolism, the need to understand the differences among the distinct models and control algorithms, and the significance of day-to-day subject variability. The key conclusion was that model-based comparisons of different control algorithms, or the models themselves, are limited by the inability to access individual model-patient parameters. It was widely agreed that these parameters, as opposed to the average parameters that are typically reported, are necessary to perform such comparisons. However, the prevailing view was that, if investigators were to make the parameters available, it would limit their ability (and that of their institution) to benefit from the invested work in developing their models. A general agreement was reached regarding the importance of each model having an insulin pharmacokinetic/pharmacodynamic profile that is not different from profiles reported in the literature (88% of the respondents agreed that the model should have similar curves or be analyzed separately) and the importance of capturing intraday variance in insulin sensitivity (91% of the respondents indicated that this could result in changes in fasting glucose of >or=15%, with 52% of the respondents believing that the variability could effect changes of >or=30%). Seventy-six percent of the participants indicated that high-fat meals were thought to effect changes in other model parameters in addition to gastric emptying. There was also widespread consensus as to how a closed-loop controller should respond to day-to-day changes in model parameters (with 76% of the participants indicating that fasting glucose should be within 15% of target, with 30% of the participants believing that it should be at target). The group was evenly divided as to whether the glucose sensor per se continues to be the major obstacle in achieving closed-loop control. Finally, virtually all participants agreed that a future two-day workshop should be organized to compare, contrast, and understand the differences among the different models and control algorithms.
Recent applications and challenges on active noise control (2013)

Acoustic noise problems become more and more serious with increasing use of industrial and medical equipment, appliances, and consumer electronics. Active noise control (ANC) has been studied to solve such acoustic noise problems. ANC is a technique based on the principle of superposition, i.e., an antinoise with the same amplitude and opposite phase is generated and combined with an unwanted noise, thus resulting in the cancellation of both noises. However, ANC is still not widely used owing to the effectiveness of control algorithms, and to the physical and economical constraints of practical applications. In this paper, we briefly introduce some fundamental ANC structures, and focus on recent advances on signal processing algorithms, implementation techniques, challenges for innovative applications, and open issues for further research and development of ANC systems.
Modeling and analysis of grain-orientation effects in emerging metal-gate devices and implications for SRAM reliability (2008)

This work introduces an analytical approach to model the random threshold voltage (V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</inf> ) fluctuations in emerging high-k/metal-gate devices caused by the dependency of metal work-function (WF) on its grain orientations. It is shown that such variations can be modeled by a multi-nomial distribution where the key parameters of its probability distribution function (pdf) can be calculated in terms of the physical dimensions of the devices and properties of the materials. It is highlighted for the first time that such variations can have significant implications for the performance and reliability of minimum sized circuits such as SRAM cells.
TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau (2021)

Tau protein plays an important role in the biology of stress granules and in the stress response of neurons, but the nature of these biochemical interactions is not known. Here we show that the interaction of tau with RNA and the RNA binding protein TIA1 is sufficient to drive phase separation of tau at physiological concentrations, without the requirement for artificial crowding agents such as polyethylene glycol (PEG). We further show that phase separation of tau in the presence of RNA and TIA1 generates abundant tau oligomers. Prior studies indicate that recombinant tau readily forms oligomers and fibrils in vitro in the presence of polyanionic agents, including RNA, but the resulting tau aggregates are not particularly toxic. We discover that tau oligomers generated during copartitioning with TIA1 are significantly more toxic than tau aggregates generated by incubation with RNA alone or phase-separated tau complexes generated by incubation with artificial crowding agents. This pathway identifies a potentially important source for generation of toxic tau oligomers in tau-related neurodegenerative diseases. Our results also reveal a general principle that phase-separated RBP droplets provide a vehicle for coassortment of selected proteins. Tau selectively copartitions with TIA1 under physiological conditions, emphasizing the importance of TIA1 for tau biology. Other RBPs, such as G3BP1, are able to copartition with tau, but this happens only in the presence of crowding agents. This type of selective mixing might provide a basis through which membraneless organelles bring together functionally relevant proteins to promote particular biological activities.
Recent Progress in Cancer Therapy With Radiolabeled Monoclonal Antibodies (2011)

"Progress in the use of RAIT for cancer therapy has been slow but steady, involving the reengineerin1g of antibodies (reducing murine component, altering size and clearance properties), and pretargeting methods for improvving tumor:blood and tumor:organ ratios are continuing to evolve".
Novel Blue Exciplex Comprising Acridine and Sulfone Derivatives as a Host Material for High-efficiency Blue Phosphorescent OLEDs (2015)

A wide-energy-gap exciplex comprising bis[4-(9,9-dimethyl-9,10-dihydroacridine-10-yl)phenyl]diphenylsilane (SiDMAC) and 9,9-bis[4-(phenylsulfonyl)phenyl]fluorene (BPSPF) was developed as a host mat...
Vibronic intensities in electronic spectra involving excited states with double-minimum potential surfaces (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVibronic intensities in electronic spectra involving excited states with double-minimum potential surfacesChristian Reber and Jeffrey I. ZinkCite this: J. Phys. Chem. 1991, 95, 23, 9151–9158Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://pubs.acs.org/doi/10.1021/j100176a023https://doi.org/10.1021/j100176a023research-articleACS PublicationsRequest reuse permissionsArticle Views73Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Changes in the Inferior Vena Cava Are More Sensitive Than Venous Pressure During Fluid Removal: A Proof-of-Concept Study (2022)

In patients undergoing ultrafiltration, changes in IVCD tracked changes in volume status better than venous pressure.
Synthesis, characterization and catalytic activity of novel ruthenium complexes bearing NNN click based ligands (2019)

Novel air stable ruthenium(ii) complexes bearing tridentate ligands bis((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine (L1), 1-(1-benzyl-1H-1,2,3-triazol-4-yl)-N-(pyridin-2-ylmethyl)methanamine (L2) or 2-(4-phenyl-1H-1,2,3-triazol-1-yl)-N-(pyridin-2-ylmethyl)ethan-1-amine (L3) were synthesised. The nitrogen based ligands were easily prepared by virtue of click chemistry using cheap and commercially available reagents. The ruthenium complexes were obtained by heating the Ru(PPh3)3Cl2 precursor and the tridentate NNN ligand in toluene under reflux for 2 hours, achieving yields of 82-87%. These complexes were fully characterized by means of NMR, FT-IR and high resolution ESI spectroscopy. The crystal structure of one of the complexes was determined. These complexes showed excellent activity and selectivity in the hydrogenation of ketones and aldehydes. DFT calculations show that complex 3 may react through an outer-sphere catalytic cycle rather than via an inner-sphere mechanism.
LED-Based Color Sensing and Control (2015)

New ways of light interaction are being enabled with the advent of light-emitting diodes (LEDs). In this paper, we describe an LED system with LED lamps and an LED array, where the LED array is used to sense color of a source lamp and then transport it to a destination lamp to adapt its color. We present a design prototype of the LED lamps and the LED array in order to realize the dual function of color sensing and illumination. A driving protocol is proposed such that color sensing may be performed, without causing an additional flicker during illumination. Depending on the wavelength selectivity of the LED devices, two methods for color estimation are proposed. Experimental results are presented to evaluate the performance of the proposed estimation method.
Non‐destructive Removal of the Bornanesultam Auxiliary in α‐Substituted N‐Acylbornane‐10,2‐sultanis under Mild Conditions: An efficient synthesis of enantiomerically pure ketones and aldehydes (1997)

Abstract α‐Substituted N ‐acylbornane‐10, 2 ‐sultams 6, 9 , and 10 can be converted into enantiomerically pure ketones 5. 13 , and 14 , respectively, via a two‐step procedure involving a known mercaptolysis reaction followed by an [Fe(acac) 3 ]‐mediated coupling of the resulting S ‐benzyl thioesters with Grignard reagents. Furthermore, enantiomerically pure aldehydes 23 can be obtained from α‐substituted N ‐acylbornane‐10,2‐sultams 6 via a one‐step reduction with (i‐Bu) 2 AIH. No epimerization at the α‐chiral center is observed during the cleavage reaction whereby the chiral auxiliary, bornane‐10,2‐sultam 1 or ent ‐ l , was recovered. By using this methodology, several natural products or precursors thereof can be prepared.
The effect of AGM-1470 in an improved intracranial 9L gliosarcoma rat model (1994)

Angiogenesis is a process fundamental to the growth of many solid tumours. Agents that inhibit angiogenesis may have a role in preventing tumour growth. AGM-1470, a synthetic analogue of fumagillin, has been shown to inhibit tumour growth in several extracranial solid tumour models. Its use has been reported to have minimal side effects. No studies have been reported using AGM-1470 in the treatment of an intracranial tumour. To determine the effect of AGM-1470 on an intracranial glial tumour, we used an improved implantation technique to place 80,000 9L tumour cells into the right caudate nucleus of 25 male Fischer 344 rats. Starting on the first post-implantation day, 12 animals received 30 mg kg-1 AGM-1470 via intraperitoneal injection every other day until death. Thirteen control animals received vehicle only. Evidence of intracranial tumour was apparent in 22/23 animals (96%). All animals treated with AGM-1470 experienced a progressive and significant weight loss when compared to controls. At day 17, treated animals retained 80.0 +/- 2.2% of their initial weight, (mean +/- SD) compared to 100.9 +/- 3.6% for controls (p = 2.25 x 10(-12); student's t-test). AGM-1470 had no effect on survival. Median survival in the treatment group was 24.5 days compared to 25 days in the controls (p = 0.95; Mann-Whitney). AGM-1470, although promising in extracranial tumour models, may not be as effective in controlling the growth of intracranial tumours, and its use is not without significant systemic effects. More studies are needed before this drug is used in human brain tumour trials.(ABSTRACT TRUNCATED AT 250 WORDS)
Cone beam reconstruction algorithm for PET-VCT (2006)

A typical X-ray CT scanner has a 50cm reconstruction field-of-view (FOV) which is significantly smaller than the 70cm FOV typically used for PET. When CT images are used for attenuation correction in PET, significant artifacts result when portions of the scanned object extend beyond 50 cm. In this paper, we present a reconstruction algorithm to estimate the missing projection samples so that a significantly larger reconstruction FOV can be achieved. The estimation is based on the observation that the total attenuation is a continuous function over views. The initial estimate of the projection distribution makes use of the property that the projection profile does not change abruptly as a function of the projection angle. When combined with the projection values at the location of truncation, the size and location of water cylinders that best fit these parameters are calculated. Additional adjustments are made to ensure the total attenuation of the expanded projection samples matches closely to the estimated total missing projection. The estimated projection is further blended with the mirror image of the measured projections near the location of truncation. Various phantom experiments were conducted to evaluate the proposed algorithm. Both axial and helical scans were collected on a 64-slice scanner. Results show that the proposed algorithm can restore the fidelity of the reconstruction for the portion of the object inside 50 cm FOV, and provide an adequate impression of the object outside 50cm.
Moderate excess alcohol consumption and adverse cardiac remodelling in dilated cardiomyopathy (2021)

DCM patients with moderate excess alcohol consumption have adverse cardiac structure and function at presentation, but this is largely due to biological sex. Alcohol may contribute to sex-specific phenotypic differences in DCM. These findings help to inform lifestyle discussions for patients with DCM.
Nanocomposites for LTD Magnetic Cores. (2016)

Abstract not provided.