gebhart/patrepeval huggingface dataset:
The effect of continuous cooking on the properties of spaghetti and its cooking water (2022)

Abstract Background and Objectives In catering environments, subsequent batches of pasta are cooked in the same water to save water and energy. This results in formation of a foam layer made up by solids leached from the pasta. Here, the effect of cooking up to 13 subsequent batches on spaghetti cooking and foaming of the cooking water was investigated. Cooking at acidic pH was also studied for a single batch. Findings Water uptake by dry spaghetti decreases with batch number. The increasingly lower mobility in the network of swollen starch and polymerized protein network reduces the extent to which albumins and globulins are leached out. Evidently, the solid content in the cooking water increases with batch number while its pH drops. Separation of pasta fragments from the cooking water does not significantly affect ( p &gt; 0.05) the foam stability. Significance and Novelty This study provides additional insights in the composition and foaming properties during the continuous cooking process of pasta.
Coastal Ocean Models as Planning Tools: A Case Study from Hurricane Katrina Storm Surge (2007)

The passage of Hurricane Katrina over the Mississippi Gulf coast has highlighted the need for and versatility of coastal ocean models as planning tools. In the case of hurricane storm surge, predicted water level maps from coastal models are sought to guide redevelopments as well as formulate future store surge mitigation strategies.
Radio Virtual Machine (2017)

Reconfigurable Radio assumes that the radio hardware platform is reconfigurable in such a way that the essential radio characteristics (carrier frequencies, spectrum bandwidth, modulation technique, coding technique, output power levels, and etc.) can be changed according to the flexibility of hardware platform that is defined by manufacturers. Corresponding radio hardware platforms are heterogeneous by nature and include computational elements with different level of programmability or reconfiguration. This paper addresses the problem of software portability and its generalization for reconfigurable platforms. Main contribution of this article is to present a novel architecture of the virtual domain-specific machine, namely, Radio Virtual Machine (RVM), which provides an efficient implementation of calculations related to radio signal processing in hardware platforms of different nature.
Synergistic Aspects of the Combination of Magnesium Hydroxide and Ammonium Polyphosphate in Flame Retardancy of Ethylene-Vinyl Acetate Copolymer (2005)

In this work, flame retardancy of ethylene-vinyl acetate copolymer (EVA) is investigated incorporating Mg(OH)2 (MDH) as flame retardant combined with ammonium polyphosphate (APP) as potential synergist. It is shown that APP is a synergistic agent in EVA-MDH formulations in terms of LOI and cone calorimetry. The interactions between APP and MDH are studied using 25Mg and 31P solid state NMR. The formation of magnesium phosphate stabilizing phosphorus in the system and it is proposed that the combination APP/MDH provides a physical/thermal barrier protecting the substrate; this barrier is constituted of magnesium phosphate glass and MgO-like ceramic. The degradation of the polymeric matrix is slowed and the flow of flammable molecules which issue from the degradation of the polymer is reduced.
Supplementary Tables 1-3 from PPP2R2C Loss Promotes Castration-Resistance and Is Associated with Increased Prostate Cancer-Specific Mortality (2023)

&lt;p&gt;PDF, 101K, Supplementary Table 1: Tissue microarray clinical-pathological parameters. Supplementary Table 2: siRNA sequences. Supplementary Table 3: qRT-PCR primer sequences.&lt;/p&gt;
Development of small silicon modulators in silicon-on-insulator (SOI) (2003)

Silicon-based optical modulators are expected to be important components in some optical networks. The optical modulation mechanism can be achieved either via the plasma dispersion effect, or by thermal means. Both are relatively slow processes when utilized in large (multi micron) waveguide structures, which researchers tend to concentrate on for ease of coupling. Using large waveguide structures limits the operating speed and hence excludes the applicability of these devices in areas where higher speeds are required. This limitation could be overcomed by using smaller waveguides (of the order of 1Rm). In this paper, we present the basic operating mechanism, design, and fabrication details of an optimum three terminal p-i-n diode based optical phase modulator based on Silicon-On-Insulator (501). The device was optimised via electrical and optical modeling and is predicted to operated at 1 .3GHz with a power reduction of900%, as compared to previously published designs.
Regulating Antifreeze Activity through Water: Latent Functions of the Sugars of Antifreeze Glycoprotein Revealed by Total Chemical Synthesis (2023)

Antifreeze glycoprotein (AFGP), which inhibits the freezing of water, is highly O-glycosylated with a disaccharide, d-Galβ1-3-d-GalNAcα (GalGalNAc). To elucidate the function of the sugar residues for antifreeze activity at the molecular level, we conducted a total chemical synthesis of partially sugar deleted AFGP derivatives, and unnatural forms of AFGPs incorporating glucose (Glc)-type sugars instead of galactose (Gal)-type sugars. These elaborated AFGP derivatives demonstrated that the stereochemistry of each sugar residue on AFGPs precisely correlates with the antifreeze activity. A hydrogen-deuterium exchange experiment using synthetic AFGPs revealed a different dynamic behavior of water around sugar residues depending on the sugar structures. These results indicate that sugar residues on AFGP form a unique dynamic water phase that disturbs the absorbance of water molecules onto the ice surface, thereby inhibiting freezing.
Magus (2015)

Planned upgrades in cellular networks occur every day, may often need to be performed on weekdays, and can potentially degrade service for customers. In this paper, we explore the problem of tuning network configurations in order to mitigate any potential impact due to a planned upgrade which takes the base station off-air. The objective is to recover the loss in service performance or coverage which would have occurred without any modifications. To our knowledge, impact mitigation for planned base station downtimes has not been explored before in the literature. The primary contribution of this work is a proactive approach based on a predictive model that uses operational data of user density distributions and path loss (rather than idealized analytical models of these) to quickly estimate the best power and tilt configuration of neighboring base stations that enables high recovery. A secondary contribution is an approach to minimize synchronized handovers. These ideas, embodied in a capability called Magus, enables us to recover up to 76% of the potential performance loss due to planned upgrades in some cases for a large US mobile network, and this recovery varies as a function of base station density. Moreover, Magus is able to reduce synchronized handovers by a factor of 8.
Issues and challenges in the performance analysis of real disk arrays (2004)

The performance modeling and analysis of disk arrays is challenging due to the presence of multiple disks, large array caches, and sophisticated array controllers. Moreover, storage manufacturers may not reveal the internal algorithms implemented in their devices, so real disk arrays are effectively black-boxes. We use standard performance techniques to develop an integrated performance model that incorporates some of the complexities of real disk arrays. We show how measurement data and baseline performance models can be used to extract information about the various features implemented in a disk array. In this process, we identify areas for future research in the performance analysis of real disk arrays.
LaAlO$_3$/SrTiO$_3$: a tale of two magnetisms (2016)

This book chapter reviews the experimental evidence for magnetic phenomena at the LaAlO3/SrTiO3 interface. We argue that essentially all of the signatures of magnetism can be sorted into two distinct categories: (1) magnetic phases (e.g., ferromagnetic or Kondo) involving local magnetic moments and their coupling to itinerant electrons; (2) metamagnetic effects that are mediated by attractive electron-electron interactions that do not involve local moments. We review possible candidates for the local moments that give rise to the ferromagnetic phases and focus on arguments for one potential source: oxygen vacancies. For the metamagnetic transport signatures, band-structure effects (e.g., Lifshitz transition) and strong attractive electron-electron interaction can help consolidate disparate experimental findings.
The modification of a single lys residue converts a molten-globule-like helix-loop-helix dimer into a native-like protein (2008)

This thesis describes the design and synthesis of molecules with potential roles in biomedicine, with an emphasis on molecular recognition in complex biological environments. The first chapter describes the synthesis and evaluation of compounds for use in nuclide therapy. Carboranes are frequently used in the development of drugs for Boron Neutron Capture Therapy. New routes for monohydroxylation at the B and C atoms of p-carborane have been developed. The Suzuki-Miyaura reaction has been applied to the cross-coupling of bis(neopentyl glycolato)diboron or bis(pinacolato)diboron and 2-I-p-carborane. The synthesized derivatives are important intermediates in the synthesis of a number of potentially biologically active carborane-containing molecules.The DNA intercalator doxorubicin has been functionalized to enable 125I labelling. The aim of combining the DNA intercalator with 125I was to achieve high delivery of cytotoxic radiation to the nucleus. The DNA-binding ability and cellular uptake of the synthesized compounds have been evaluated. One of the compounds bound strongly to DNA and had similar cellular uptake as daunorubicin, which makes the compound very interesting for further biological evaluation.The second chapter describes the use of polypeptide conjugates to broaden our knowledge of molecular recognition. The polypeptides consist of 42 amino acids each and are designed to fold into helix-loop-helix motifs that dimerize due to their amphiphilic character. The polypeptides are combined with a variety of small organic molecules. The incorporation of small aromatic molecules to influence the structure and dynamics of a polypeptide has been investigated. By attaching a dansyl group to the side chain of a lysine residue, the dynamics of the protein’s hydrophobic core where affected to such a degree that a native-like fold was formed. The polypeptide conjugates have also been used to study the binding and recognition of native proteins. High-affinity binders for chitinases and acetylcholine esterase have been developed and evaluated.
071 Hedgehog Signalling Regulates Leydig Stem Cell Function in Subcutaneous Autograft (2019)

Exogenous testosterone supplementation can be used to treat low testosterone; however, it has several adverse effects including infertility due to negative feedback on the hypothalamic-pituitary-gonadal (HPG) axis. We evaluated the feasibility of subcutaneously autografting Leydig stem cells (LSC) in combination with Sertoli and myoid cells to increase testosterone. Furthermore, we evaluated the mechanism essential for survival of LSC in extra-testicular milieu. We performed orchiectomy in sixteen adult C57/BL6 mice (subcutaneous autograft (n=8); negative controls(n=5); positive control(n=3) – testosterone pellet) and five mice were used as sham controls. Leydig stem cells were harvested from testis by collagenase/trypsin digestion. Cells from each mouse were allowed to grow separately in the media containing DMEM, FBS (10%), P/S, ITS, Dexamethasone, EGF, PDGF-AA. After 10 days following orchiectomy, 1 X 106 cells from four animals were autografted in the subcutaneous tissue with matrigel (1:1). Grafts were harvested at two weeks (n=3 autografted) and after four weeks (n=18), and blood was collected. We evaluated testosterone production, graft morphology, and expression of Leydig cell markers. Furthermore, to evaluate Hedgehog signalling on graft differentiation, LSC’s in-vitro were treated with Vismodigib (Hedgehog inhibitor) and SAG (Hedgehog inducer). Expression of Hedgehog signalling markers and LSC differentiation marker was evaluated by qRT-PCR. Additionally, LSC’s, upon treatment with Vismodigib and SAG were subcutaneously autografted in mice for 4 weeks.
Three-dimensional nuclear magnetic resonance imaging of green-state ceramics (1991)

Objective is the development of nuclear magnetic resonance imaging techniques and technology applicable to the nondestructive characterization of green-state ceramics. To this end, a three-dimensional (3-D) NMR imaging technique has been developed, based on a back-projection acquisition protocol in combination with image reconstruction techniques that are based on 3-D Radon transform inversion. The method incorporates the experimental flexibility to overcome many of the difficulties associated with imaging of solid and semisolid broad-line materials, and also provides contiguously sampled data in three dimensions. This technique has been evaluated as a nondestructive characterizauon method for determining the spatial distribution of organic additves in green-state injection-molded cylindrical Si{sub 3}N{sup 4} tensile specimens. The technique has been evaluated on the basis of providing moderate image resolution over large sample volumes, high resolution over smaller specimen volumes, and sensitivity to variations in the concentration of organics. Resolution of 200{mu}m has been obtained with excellent sensitivity to concentration. A detailed account of the 3-D imaging results obtained from the study, a discussion of the difficulties and limitations of the imaging technique, and suggestions for technique and system improvements are included.
Deriving efficient sql sequences via prefetching (2008)

Modern information architectures place business logic in an application server and persistent objects in a relational DBMS. To effectively realize such architectures, we must surmount the problem of effectively fetching objects from DBMS to the application server. Object access patterns are not random; they are driven by applications and user behaviors. Naive implementations retrieve objects from the DBMS as such objects are requested by the application, costing a DBMS roundtrip for each query. This fact, coupled with the growing performance bottleneck of computer storage systems, has resulted in a significant amount of research improving object access behavior through predicting future access objects because throughput will continue to improve but latency will not. Latency will be an ever-increasing component of object access cost. In turn, object access cost is usually the bottleneck for modern high performance systems. This yields unacceptably poor performance when application server submits sequence of relational queries to DBMSs. 
A reasonable approach would be to generate prefetch queries that retrieve objects that would later be requested by the application. However, whereas some prefetch queries would be beneficial, some would not. Distinguishing between them is nontrivial in practice, because commercial DBMSs do not expose efficient query response-time estimators. First, there is no standardized interface for an application server to force the database system to calculate the costs (e.g., response time) for a given query. Second, we still have the entire roundtrip costs between application servers and the DBMSs to estimate the total cost of query evaluation. Consequently, in current practice, programmers spend enormous amounts of time tuning the queries by which objects are retrieved by an application. 
This dissertation develops an application-independent approach for generating prefetch queries that can be implemented in conventional middleware systems. The main contribution of this dissertation is a set of application-independent guidelines for selecting, based on application's access patterns and additional parameters, efficient ways of merging the application's data requests into prefetch queries. Our guidelines take the current configuration such as local or wide area networks into account, allowing it to select strategies that give good performance in a wider range of configurations. The ensuing performance gains are evaluated via realistic settings based on a retail database inspired by the SPECJ performance test suite.
Design of polymerase chain reaction primers for the selective amplification of HIV-1 RNA in the presence of HIV-1 DNA (1992)

Since the presence of HIV-1 RNA is indicative of HIV-1 replication for the presence of HIV-1 virions, the RNA-specific primer described should facilitate the assessment of HIV-1 replication and the plasma HIV-1 viral load in HIV-1-infected individuals. This should prove useful in the evaluation of the effects of therapeutic interventions on HIV-1 infection.
Elicitation of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Mucosal Compartments of Rhesus Monkeys by Systemic Vaccination (2002)

Since most human immunodeficiency virus (HIV) infections are initiated following mucosal exposure to the virus, the anatomic containment or abortion of an HIV infection is likely to require vaccine-elicited cellular immune responses in those mucosal sites. Studying vaccine-elicited mucosal immune responses has been problematic because of the difficulties associated with sampling T lymphocytes from those anatomic compartments. In the present study, we demonstrate that mucosal cytotoxic T lymphocytes (CTL) specific for simian immunodeficiency virus (SIV) and simian HIV can be reproducibly sampled from intestinal mucosal tissue of rhesus monkeys obtained under endoscopic guidance. These lymphocytes recognize peptide-major histocompatibility complex class I complexes and express gamma interferon on exposure to peptide antigen. Interestingly, systemic immunization of monkeys with plasmid DNA immunogens followed by live recombinant attenuated poxviruses or adenoviruses with genes deleted elicits high-frequency SIV-specific CTL responses in these mucosal tissues. These studies therefore suggest that systemic delivery of potent HIV immunogens may suffice to elicit substantial mucosal CTL responses.
Quantitative Imaging of B1 Cyclin Expression Across the Cell Cycle Using Green Fluorescent Protein Tagging and Epifluorescence (2020)

In this article, we report the number of cyclin B1 proteins tagged with enhanced green fluorescent protein (eGFP) in fixed U-2 OS cells across the cell cycle. We use a quantitative analysis of epifluorescence to determine the number of eGFP molecules in a nondestructive way, and integrated over the cell we find 10<sup>4</sup> to 10<sup>5</sup> molecules. Based on the measured number of eGFP tagged cyclin B1 proteins, knowledge of cyclin B1 dynamics through the cell cycle, and the cell morphology, we identify the stages of cells in the cell cycle. © 2020 The Authors. Cytometry Part A published by Wiley Periodicals LLC. on behalf of International Society for Advancement of Cytometry.
Ultrasound characterization of slow precipitating implants for vascular occlusion (2017)

A current standard clinical treatment for liver cancer patients is drug eluting bead trans-arterial chemoembolization (DEB-TACE), where doxorubicin-loaded microparticles are injected via catheter into the hepatic artery that feeds the tumor. Due to the large bead diameter (~200μm), occlusion occurs far away from the tumor creating a hypoxic region affecting both healthy and cancerous tissue. As an alternative to beads, we have developed a slow precipitating occlusion solution (sPI) which will be capable of continuous, deeper occlusion. Because the precipitation rate of the solution is critical to the penetration depth, and to the eventual success of this application, this study tested the feasibility of controlling solution precipitation by increasing polymer to solvent ratios and evaluating the occlusion distance using ultrasound imaging in a tissue-mimicking flow phantom.
Exclusion of Lumbar Arteries by Aortic Endovascular Grafts: Can Angiography Demonstrate Sealing Characteristics? (1998)

The immediate angiographic demonstration of exclusion of lumbar arteries predicts sealing characteristics of endovascular grafts. Later angiographic reappearance is due to development of a collateral network and possible shortening of self-expandable devices.
Risk factors for surgical site infection after kidney and pancreas transplantation (2018)

Organ/space SSIs remain a serious and common complication after SPK and PAK. Prolonged cold ischemic time and SPK transplant were the risk factors predictive of SSIs. Appropriate perioperative prophylaxis in high-risk patients targeting the potential pathogens producing SSIs in kidney and/or pancreas transplant recipients and a reduction in cold ischemia may prove beneficial in reducing these SSIs.
α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH) (2017)

Given the putative role of PHGDH in cancer, development of inhibitors is required to explore its function. In this context, we established and validated a straightforward enzymatic assay suitable for high-throughput screening and we identified inhibitors with similar chemical scaffolds. Through a convergent pharmacophore approach, we synthesized α-ketothioamides that exhibit interesting in vitro PHGDH inhibition and encouraging cellular results. These novel probes may be used to understand the emerging biology of this metabolic target.
Fast Adjustment Scheme on Vector Regulator of Power Amplifier for Massive MIMO Base Stations (2022)

This paper proposes a fast adjustment scheme on vector regulator of power amplifier (PA) for Massive MIMO base stations. The configuration of the PA corresponds to a signal cancellation circuit of feed-forward PA. The proposed scheme estimates the input power to the PA using kNN (k-Nearest Neighbor) method based on the experimental data and sets the gain and phase values of the vector regulator in accordance with the estimated input power. Experimental results using 3.5 GHz-band PA show that the proposed scheme adjusts the vector regulator approximately within 15 seconds to achieve the target suppression amount of over 30 dB.