gebhart/patrepeval huggingface dataset:
A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI (2009)

Hyperpolarized (HP) (3)He magnetic resonance imaging has been recently used to produce high-resolution images of pulmonary ventilation after methacholine (MCh) challenge in mouse models of allergic inflammation. This capability presents an opportunity to gain new insights about these models and to more sensitively evaluate new drug treatments in the pre-clinical setting. In the current study, we present our initial experience using two-dimensional (2D), time-resolved (3)He MRI of MCh challenge-induced airways hyperreactivity (AHR) to compare ovalbumin-sensitized and challenged (N = 8) mice to controls (N = 8). Imaging demonstrated that ovalbumin-sensitized and challenged animals exhibited many large ventilation defects even prior to MCh challenge (four out of eight) compared to no defects in the control animals. Additionally, the ovalbumin-sensitized and challenged animals experienced a greater number of ventilation defects (4.5 +/- 0.4) following MCh infusion than did controls (3.3 +/- 0.6). However, due to variability in MCh delivery that was specific to the small animal MRI environment, the difference in mean defect number was not statistically significant. These findings are reviewed in detail and a comprehensive solution to the variability problem is presented that has greatly enhanced the magnitude and reproducibility of the MCh response. This has permitted us to develop a new imaging protocol consisting of a baseline 3D image, a time-resolved 2D series during MCh challenge, and a post-MCh 3D image that reveals persistent ventilation defects.
High-risk human papillomavirus positive primary squamous cell carcinoma of the lacrimal gland: a case report (2020)

A 78-year-old Caucasian female presented with a painless mass in the right orbit that had progressively enlarged over several months. Computed tomography scan of the orbits showed a right lacrimal gland mass with no bony erosion. Histopathologic analysis of the biopsy specimen revealed invasive squamous cell carcinoma positive via in-situ hybridization for high-risk human papillomavirus. The patient underwent successful removal of the right lacrimal gland tumor en bloc, followed by adjuvant radiotherapy. This is an extremely rare case of primary squamous cell carcinoma of the lacrimal gland and the first report describing human papillomavirus positivity in this tumor location.
Use of color image correlation in the retrieval of gastric surface topography by endoscopic stereopair matching (1988)

We propose finding an optimal generalized color plane to carry out digital color image correlation. We seek the optimization of the correlation peak's sharpness and, for the purpose of analysis, we make some assumptions regarding the statistical properties of images to be considered. The analysis leads to a simple solution involving a projection onto the Karhunen-Loeve vectors corresponding to the smallest eigenvalues of the interprimary colors covariance matrix. We use our results in the retrieval of the gastric mucosal surface structure from stereopairs taken through an endoscope. Study of the statistics of the endoscope images shows that the assumptions used earlier can be applied to this type of image. We present some results of stereopair matching with color image correlation. We conclude by proposing a pseudo-3-D surface reconstruction of the gastric surface by mapping the endoscopic image onto the retrieved elevation information.
Delay-line phase-shifter Based Beamforming antenna for sub-6GHz 5G Mobile Communication (2019)

In this paper, a wideband phase shifter architecture using a new switching network is proposed. The new reference network consists of coupled lines and open stubs, respectively, and the delay network only consists of standard transmission lines. Since the phase scattering characteristics according to the right mode and the mode-mode impedance ratio R of the coupled line and the characteristic impedance ZM of the main transmission line and the stronger phase scattering characteristic due to the characteristic impedance ZS of the open stub are used together 45 °, 90 °, 135 ° phase shifter can be designed. Also, based on the derived formula, we confirmed the resonance frequency of the matrix circuit designed through CST-MWS, confirmed the S-parameter and radiation pattern at 3.5GHz which is the resonance frequency band, and investigated the optimization.
Effectiveness of Sodium Hypochlorite in the Prevention of Catheter Related Infections (2006)

Vascular access in hemodialysis is a major point of concern in the management of chronic patients. Although arteriovenous fistula remains as the access of first choice, tunneled central venous catheters are still commonly used. Infection remains the principal cause of catheter dysfunction or loss. Many protocols have been used in order to prevent exit site infections and bacteremia. We describe our experience with the use of sodium hypochlorite, an electrolytic chloroxidizer used as a topical disinfectant. It has been shown to be active against a broad spectrum of potential pathogens and has other specific advantages compared to other cleansing agents, including its non-toxic, non-irritating nature and its low cost. We conclude that sodium hypochlorite solution in different concentrations (10 and 50%) is effective in preventing exit site infections and bacteremia associated with tunneled central venous catheters in chronic hemodialysis patients.
Virtual-Flux Decoupling Hysteresis Control for the five-level ANPC inverter connected to the grid (2008)

Interest in multilevel power converters has been increased in the last decades due to numerous advantages. Therefore, new control concepts have to be developed or existing control techniques must be extended to take advantage of these benefits.However, although multilevel inverters present numerous advantages, some drawbacks are evident. They require a higher number of semiconductors and either multiple isolated dc sources or a bank of series connected capacitors. Consequently, the control complexity increases considerably, since more switching devices normally result in a higher number of possible combinations and the balance of the capacitors has to be guaranteed. In order to fulfill these requirements, this paper extends the Virtual-Flux Decoupling Hysteresis Control (VF-DHC) scheme previously presented for the classical two-level and the industry standard three-level NPC inverters to operate with the recently introduced five-level Active Neutral-Point Clamped Inverter (ANPC).
PO-0723 Possible advantages of probabilistic planning for head and neck cancer (2012)

To investigate possible advantages of uncertainty based probabilistic planning (PP) compared to conventional margin- based planning applied to five head and neck (HN instead, both systematic and random errors are explicitly handled during optimization and evaluation. We hypothesized that thanks to a PP approach we would be able to maintain the dose to the tumour target while decreasing the dose to the Organs at Risks (OAR)
Effect of interfaces on surface potential decay on double layered HTV silicone rubber samples (2016)

Interfaces between materials constituting composite HVDC insulation systems are typically associated with abrupt changes of the materials' dielectric properties, which cause accumulation of interfacial charges. These may affect various processes in the insulation system, including dynamics of charge transport and electric field distribution as well as its flashover performance. In the present study, the influence of macroscopic interfaces between layers made of high temperature vulcanized silicone rubbers on surface potential decay characteristics is analyzed. It is shown by comparing results of measurements on single and double layered samples that the rate of the potential decay may be significantly changed (increased or reduced) depending on how the layered structure is designed. The performed analyses show that the observed features cannot be explained by means of classical Maxwell-Wagner model and introducing additional charges at the investigated interface is necessary to successfully model the experimental data. The presented discussion concentrates on defining possible sources of such interfacial charges.
Continuous Mesoporous Pd Films by Electrochemical Deposition in Nonionic Micellar Solution (2017)

Mesoporous metals that combine catalytic activity and high surface area can provide more opportunities for electrochemical applications. Various synthetic methods, including hard and soft templating, have been developed to prepare mesoporous/nanoporous metals. Micelle assembly, typically involved in soft-templates, is flexible and convenient for such purposes. It is, however, difficult to control, and the ordering is significantly destroyed during the metal deposition process, which is detrimental when it comes to designing precisely mesostructured materials. In the present work, mesoporous Pd films were uniformly electrodeposited using a nonionic surfactant, triblock copolymer poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide), as a pore-directing agent. The interaction between micelles and metal precursors greatly influences the metal growth and determines the final structure. The water-coordinated species interact with the ethylene oxide moiety of the micelles to effectively drive the Pd(II) species toward the working electrode surface. From small-angle neutron scattering data, it is found that spherical P123 micelles, with an average diameter of ∼14 nm, are formed in the electrolyte, and the addition of Pd ions does not significantly modify their structure, which is the essence of the micelle assembly approach. The uniformly sized mesopores are formed over the entire mesoporous Pd film and have an average pore diameter of 10.9 nm. Cross-sectional observation of the film also shows mesopores spanning continuously from the bottom to the top of the film. The crystallinity, crystal phase, and electronic coordination state of the Pd film are also confirmed. Through this study, it is found that the optimized surfactant concentration and applied deposition potential are the key factors to govern the formation of homogeneous and well-distributed pores over the entire film. Interestingly, the as-prepared mesoporous Pd films exhibit superior electrocatalytic activity toward the ethanol oxidation reaction by fully utilizing the accessible active surface area. Our approach combines electrochemistry with colloidal and coordination chemistry and is widely applicable to other promising metals and alloy electrocatalysts.
Characterization of SR 121463A, a highly potent and selective, orally active vasopressin V2 receptor antagonist. (1996)

SR 121463A, a potent and selective, orally active, nonpeptide vasopressin V2 receptor antagonist, has been characterized in several in vitro and in vivo models. This compound displayed highly competitive and selective affinity for V2 receptors in rat, bovine and human kidney (0.6 < or = Ki [nM] < or = 4.1). In this latter preparation, SR 121463A potently antagonized arginine vasopressin (AVP)-stimulated adenylyl cyclase activity (Ki = 0.26+/-0.04 nM) without any intrinsic agonistic effect. In autoradiographic experiments performed in rat kidney sections, SR 121463A displaced [3H]AVP labeling especially in the medullo-papillary region and confirmed that it is a suitable tool for mapping V2 receptors. In comparison, the nonpeptide V2 antagonist, OPC-31260, showed much lower affinity for animal and human renal V2 receptors and lower efficacy to inhibit vasopressin-stimulated adenylyl cyclase (Ki in the 10 nanomolar range). Moreover, OPC-31260 exhibited a poor V2 selectivity profile and can be considered as a V2/V1a ligand. In normally hydrated conscious rats, SR 121463A induced powerful aquaresis after intravenous (0.003-0.3 mg/kg) or oral (0.03-10 mg/kg) administration. The effect was dose-dependent and lasted about 6 hours at the dose of 3 mg/kg p.o. OPC-31260 had a similar aquaretic profile but with markedly lower oral efficacy. The action of SR 121463A was purely aquaretic with no changes in urine Na+ and K+ excretions unlike that of known diuretic agents such as furosemide or hydrochlorothiazide. In addition, no antidiuretic properties have been detected with SR 121463A in vasopressin-deficient Brattleboro rats. Thus, SR 121463A is the most potent and selective, orally active V2 antagonist yet described and could be a powerful tool for exploring V2 receptors and the therapeutical usefulness of V2 blocker aquaretic agents in water-retaining diseases.
Trans-10,cis-12 conjugated linoleic acid (CLA) induces a G1 cell cycle arrest in HT-29 human colon cancer cells (2004)

Proc Amer Assoc Cancer Res, Volume 45, 2004

3897 

A commercially available mixture of CLA isomers reduces the incidence of colon tumors in rats treated with 1,2-dimethylhydrazine. CLA is a collective term used to denote one or more positional and geometric isomers of octadecadienoic acid with cis -9, trans -11 and trans -10, cis -12 CLA being the principal isomers. Our previous in vitro studies have shown that trans -10, cis -12 CLA inhibited the growth of HT-29 cells, whereas cis -9, trans -11 CLA had no effect on the cell growth. In the present study, to examine the effects of the CLA isomers on cell cycle and cell cycle regulatory proteins, HT-29 cells were treated with various concentrations (0 –4 μM) of the individual CLA isomers. Results from DNA flow cytometric analysis revealed that trans -10, cis -12 CLA induced a G1 arrest, whereas cis -9, trans -11 CLA had no effect on the cell cycle. Western blot analysis of total cell lysates revealed that trans -10, cis -12 CLA did not alter the protein expression of either cyclin A, D, and E or cyclin-dependent kinase (CDK) 2 and 4. However, trans -10, cis -12 CLA substantially increased the protein expression and mRNA accumulation of the CDK inhibitor p21Cip1/WAF1. Trans -10, cis -12 CLA decreased phosphorylated retinoblastoma protein (Rb) levels without any change in total Rb protein levels. In vitro kinase assay by using Histone H1 as a substrate showed that CDK 2 activities were markedly decreased by trans -10, cis -12 CLA. These results indicate that CLA inhibits the growth of colon cancer cells by inducing a G1 cell cycle arrest. Induction of p21Cip1/WAF1 may be one of the mechanisms by which CLA inhibits cell cycle progression in HT-29 cells. Supported by grant No. [R01-1999-000-00166-0 (2003)] from the Basic Research Program of the Korea Science & Engineering Foundation.
Low-Shrinkage Resin Matrices in Restorative Dentistry-Narrative Review (2022)

Dimethacrylate-based resin composites restorations have become widely-used intraoral materials in daily dental practice. The increasing use of composites has greatly enhanced modern preventive and conservative dentistry. They have many superior features, especially esthetic properties, bondability, and elimination of mercury and galvanic currents. However, polymeric materials are highly susceptible to polymerization shrinkage and stresses that lead to microleakage, biofilm formation, secondary caries, and restoration loss. Several techniques have been investigated to minimize the side effects of these shrinkage stresses. The primary approach is through fabrications and modification of the resin matrices. Therefore, this review article focuses on the methods for testing the shrinkage, as well as formulations of resinous matrices available to reduce polymerization shrinkage and its associated stress. Furthermore, this article reviews recent cutting-edge developments on bioactive low-shrinkage-stress nanocomposites to effectively inhibit the growth and activities of cariogenic pathogens and enhance the remineralization process.
Miniature reconfigurable multi-antenna system for IMT-Advanced band (2011)

This paper presents a compact reconfigurable multi-antenna system addressing the IMT-Advanced band. The antenna system is built using compact antennas whose miniaturization is obtained by limiting instantaneous operating bandwidth. Frequency agility technique it then used to enlarge the operating frequency in accordance with the whole operating band and communication standard waveform. Good decoupling performances are achieved with the multi-antenna device thanks to a particular arrangement of the antennas. This system has been introduced for small mobile terminals, where form factor is very important. The use of two antennas could bring benefits to limit fast fading effects introduced by mobility.
Isolation and characterization of α-enolase, a novel fibronectin-binding protein from Streptococcus suis (2008)

Streptococcus suis is an important swine pathogen that causes meningitis, endocarditis, arthritis and septicaemia. As a zoonotic agent, S. suis also causes similar diseases in humans. Binding of pathogenic bacteria to extracellular matrix components enhances their adhesion to and invasion of host cells. In the present study we isolated and identified a novel fibronectin-binding protein from S. suis. The native protein (designated SsEno) possessed not only high homology with other bacterial enolases but also enolase activity. We cloned, expressed and purified SsEno and showed that it is ubiquitously expressed by all S. suis serotypes and we identified its surface localization using immunoelectron microscopy. ELISA demonstrated that SsEno binds specifically to fibronectin and plasminogen in a lysine-dependent manner. Additional surface plasmon resonance assays demonstrated that SsEno binds to fibronectin or plasminogen with low nanomolar affinity. Inhibition experiments with anti-SsEno antibodies also showed that bacterial SsEno is important for the adhesion to and invasion of brain microvascular endothelial cells by S. suis. Overall, the present work is the first study, to our knowledge, to demonstrate a fibronectin-binding activity of a bacterial enolase, and shows that, similar to other bacterial fibronectin-binding proteins, SsEno may contribute to the virulence of S. suis.
Optically detected magnetic resonance via the magnetic circular dichroism of absorption of cerium impurities in bulk paramagnetic terbium gallium garnet (1997)

The paramagnetic resonance of dilute ions in the bulk paramagnetic host is separated from the host response by means of optically detected magnetic resonance (ODMR) using the magnetic circular dichroism (MCD) of the absorption. This result shows that it is possible in principle to extend by means of the ODMR of the absorption the regime of paramagnetic resonance detection of impurity ions to magnetic hosts, which strongly interact with the microwave field and, hence, make the impurity signals unobservable by means of conventional EPR. The observed ODMR signals are attributed to and ions by correlation with the optical bands of these species. By means of ODMR via the Faraday effect it is shown that this effect is due to transitions between Tb levels. The identification of the observed magnetic resonance structures is confirmed by calculations based on known information on and in diamagnetic hosts. The role of molecular fields is discussed.
Hypercholesterolemia Promotes Leukocyte‐Dependent Platelet Adhesion in Murine Postcapillary Venules (2004)

The findings demonstrate that the pro-thrombogenic phenotype assumed in the microvasculature during hypercholesterolemia is largely attributed to leukocyte-dependent platelet adhesion.
InP 2D Photonic Crystal Lasers integrated onto SOI waveguides (2009)

We report on the fabrication of InP-based 2D photonic crystal lasers operating around 1.5μm at room temperature integrated and evanescently coupled to SOI waveguides. Laser operation is obtained from a line defect structure accurately aligned on top the SOI circuitry.
A Pseudo-Rigid-Body Model for Rolling-Contact Compliant Beams (2007)

This paper presents a pseudo-rigid-body model (PRBM) for rolling-contact compliant beams (RCCBs). The loading conditions and boundary conditions for the RCCB can be simplified to an equivalent cantilever beam that has the same force-deflection characteristics as the RCCB. Building on the PRBM for cantilever beams, this paper defines a model for the force-deflection relationship for RCCBs. The definition of the RCCB PRBM includes the pseudo-rigid-body model parameters that determine the shape of the beam, the length of the corresponding pseudo-rigid-body links and the stiffness of the equivalent torsional spring. The behavior of the RCCB is parameterized in terms of a single parameter defined as clearance, or the distance between the contact surfaces. RCCBs exhibit a unique force-displacement curve where the force is inversely proportional to the clearance squared.
Myocardial Fiber Shortening in Humans: Initial Results of MR Imaging (2000)

Registered diffusion and strain MR imaging can be used quantitatively to map fiber orientation and its relations to myocardial deformation in humans.
Metalorganic chemical vapor deposition grown n-InGaN/n-GaN tunnel junctions for micro-light-emitting diodes with very low forward voltage (2020)

Abstract High performance GaN-based micro-light-emitting diodes (µLEDs) with epitaxial n-InGaN/n-GaN tunnel junctions (InGaN TJs) were grown by metalorganic chemical vapor deposition (MOCVD). The InGaN TJs µLEDs show a significant reduction of forward voltage (V f ) by ∼0.6 V compared to the common TJs µLEDs. The V f at 20 A cm −2 is very low varied from 3.15 V to 3.19 V in small InGaN TJ µLEDs with a size less than 40 × 40 µ m 2 , and then significantly increases in large LEDs. Selective area growth (SAG) of TJs can overcome such size limitation by vertical out diffusion of hydrogen through the apertures on top of p-GaN. The InGaN TJ µLEDs overgrown by SAG show a size-independent low V f ranged from 3.08 V to 3.25 V. The external quantum efficiency (EQE) of the packaged TJ µLEDs was improved by 6% compared to the common µLEDs with indium tin oxide (ITO) contact. This work solves the key challenges of MOCVD-grown TJs.
Virtually scaling-free adaptive CORDIC rotator (2004)

The authors propose a coordinate rotation digital computer (CORDIC) rotator algorithm that eliminates the problems of scale factor compensation and limited range of convergence associated with the classical CORDIC algorithm. In the proposed scheme, depending on the target angle or the initial coordinate of the vector, a scaling by 1 or 1/√2 is needed that can be realised with minimal hardware. The proposed CORDIC rotator adaptively selects the appropriate iteration steps and converges to the final result by executing on average only 50% of the number of iterations required by the classical CORDIC. Unlike for the classical CORDIC, the value of the scale factor is completely independent of the number of executed iterations. Based on the proposed algorithm, a 16-bit pipelined CORDIC rotator was implemented. The silicon area of the fabricated pipelined CORDIC rotator core is 2.73 mm2. This is equivalent to 38 000 inverter gates in the used 0.25 μm BiCMOS technology. The average dynamic power consumption of the fabricated CORDIC rotator is 17 mW at a 2.5 V supply voltage and a 20 Ms/s throughput. Currently, this CORDIC rotator is used as a part of the baseband processor for a project that aims to design a single-chip wireless modem compliant with the IEEE 802.11a standard.