gebhart/patrepeval huggingface dataset:
A Covariance-Based Superpositional CPHD Filter for Multisource DOA Tracking (2017)

Direction of arrival (DOA) estimation of multiple sources using an array of sensors is a well-known problem in signal processing. Most DOA estimation methods use second-order measurements in the form of covariance matrices obtained from consecutive snapshots of the array elements' raw data. In this paper, we pose the covariance-based DOA estimation problem in the random finite set framework of multitarget tracking using a superpositional model. The superpositional model allows for the measurements to be directly incorporated into a track-before-detect approximate cardinalized probability hypothesis density filter with a likelihood distributed as a complex Wishart random matrix that can perform DOA tracking with unknown time-varying number of sources. Complex Wishart and inverse-Wishart conjugacy is employed to derive the filter's update equations. The proposed filter is implemented using an auxiliary particle filter and simulation results showcase its improved performance in challenging scenarios of low (negative) signal-to-noise ratio and small number of snapshots.
The Direct Synthesis of Dibromomethylphosphonic Dibromide and Some of Its Derivatives (1979)

Abstract Compound CHBr2P(O)Br2 has been synthesized by smooth hydrolysis of the [CHBr3,PBr3,AlBr3] adduct prepared in situ. This compound in turn gave access to related dibromomethylphosphonic diesters, diamides and the difluoride in high yields.
Changes in duodenal tissue-associated microbiota following hookworm infection and consecutive gluten challenges in humans with coeliac disease (2016)

A reduced diversity of the gastrointestinal commensal microbiota is associated with the development of several inflammatory diseases. Recent reports in humans and animal models have demonstrated the beneficial therapeutic effects of infections by parasitic worms (helminths) in some inflammatory disorders, such as inflammatory bowel disease (IBD) and coeliac disease (CeD). Interestingly, these studies have described how helminths may alter the intestinal microbiota, potentially representing a mechanism by which they regulate inflammation. However, for practical reasons, these reports have primarily analysed the faecal microbiota. In the present investigation, we have assessed, for the first time, the changes in the microbiota at the site of infection by a parasitic helminth (hookworm) and gluten-dependent inflammation in humans with CeD using biopsy tissue from the duodenum. Hookworm infection and gluten exposure were associated with an increased abundance of species within the Bacteroides phylum, as well as increases in the richness and diversity of the tissue-resident microbiota within the intestine, results that are consistent with previous reports using other helminth species in humans and animal models. Hence, this may represent a mechanism by which parasitic helminths may restore intestinal immune homeostasis and exert a therapeutic benefit in CeD, and potentially other inflammatory disorders.
The pleiotropic function of Delta during postembryonic development of Drosophila melanogaster. (1993)

Analysis of the development of Delta (Dl) temperature-sensitive mutants pulsed at restrictive temperature during larval and pupal stages reveals multiple phenocritical periods during which reduction of Dl function affects viability and development of adult structures. Dl function is required during the third larval instar for post-pupal viability and during the first day of pupal development for viability through eclosion. Dl function is required biphasically for the development of sensory bristles. Earlier pulses lead to bristle multiplication and later pulses lead to bristle loss. The exact intervals during which multiplication and loss are induced vary for different bristles. Dl function is also required for development of most, if not all, cell types in the retina. Different pulses result in reduction in eye size, scarring, and glossiness, as well as multiplication and loss of interommatidial bristles. We also define intervals during which Dl function is required for aspects of leg and wing development. Phenocritical periods for Dl function are temporally coincident with those previously reported for Notch (N), consistent with the hypothesis that the proteins encoded by Dl and N interact throughout development to assure correct specification of cell fates in a variety of imaginal tissues.
Oxidative Metabolism of a Quinoxaline Derivative by Xanthine Oxidase in Rodent Plasma (2011)

As part of efforts directed at the G protein-coupled receptor 119 agonist program for type 2 diabetes, a series of cyanopyridine derivatives exemplified by isopropyl-4-(3-cyano-5-(quinoxalin-6-yl)pyridine-2-yl)piperazine-1-carboxylate (1) were identified as novel chemotypes worthy of further hit-to-lead optimization. Compound 1, however, was found to be unstable in plasma (37 °C, pH 7.4) from rat (T(1/2) = 16 min), mouse (T(1/2) = 61 min), and guinea pig (T(1/2) = 4 min). Lowering the temperature of plasma incubations (4-25 °C) attenuated the degradation of 1, implicating the involvement of an enzyme-mediated process. Failure to detect any appreciable amount of 1 in plasma samples from protein binding and pharmacokinetic studies in rats was consistent with its labile nature in plasma. Instability noted in rodent plasma was not observed in plasma from dogs, monkeys, and humans (T(1/2) > 370 min at 37 °C, pH 7.4). Metabolite identification studies in rodent plasma revealed the formation of a single metabolite (M1), which was 16 Da higher than the molecular weight of 1 (compound 1, MH(+) = 403; M1, MH(+) = 419). Pretreatment of rat plasma with allopurinol, but not raloxifene, abolished the conversion of 1 to M1, suggesting that xanthine oxidase (XO) was responsible for the oxidative instability. Consistent with the known catalytic mechanism of XO, the source of oxygen incorporated in M1 was derived from water rather than molecular oxygen. The formation of M1 was also demonstrated in incubations of 1 with purified bovine XO. The structure of M1 was determined by NMR analysis to be isopropyl-4-(3-cyano-5-(3-oxo-3,4-dihydroquinoxalin-6-yl)pyridine-2-yl)piperazine-1-carboxylate. The regiochemistry of quinoxaline ring oxidation in 1 was consistent with ab initio calculations and molecular docking studies using a published crystal structure of bovine XO. A close-in analogue of 1, which lacked the quinoxaline motif (e.g., 5-(4-cyano-3-methylphenyl)-2-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)nicotinitrile (2)) was stable in rat plasma and possessed substantially improved GPR119 agonist properties. To the best of our knowledge, our studies constitute the first report on the involvement of rodent XO in oxidative drug metabolism in plasma.
Substrate-aware mixed-signal macro-cell placement in WRIGHT (2002)

In this paper we describe a set of algorithms for handling substrate-coupled switching noise in an iterative placement framework. Our model for switching noise uses a coarse resistive grid method for analyzing the coupling of digital switching noise into the analog macros on the chip. The noise effects determined through these models are incorporated into a constrained, simulated annealing based macro cell placement flow. Our results indicate that these substrate-aware algorithms support efficient mixed signal placement optimization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Explaining the Riddle of Tension Stiffening Models for Shear Panel Experiments (2005)

Analyses of reinforced and prestressed concrete structures based on a smeared crack approach generally include a tension stiffening relationship to estimate the average concrete tensile stress after cracking. Many such equations have been developed over the years and show significant differences between them. In this study, three of these equations are compared and it is shown that the variation between the equations can be explained by the different bond conditions of the specimens tested to calibrate the equations. An expression is proposed to quantify this effect and sample results are shown. Use of this relationship should allow more realistic estimates of crack width and stiffness at service loads to be obtained.
Experiment and simulation of sub-0.25-μm resist processes for 193-nm lithography (1993)

A model was developed to simulate the behavior of near-surface-imaged resist processes, with the emphasis on modeling of resist processes for 193 nm. Silylation, bilayer, and additive resist processes can all be simulated using this model. For the silylation process, the model was found to be in excellent agreement with experimentally observed silylated resist profiles. This model was used in combination with existing programs that calculate aerial images and single-layer resist profiles to predict process margins for 193 nm (0.5 NA) lithography. The results of our simulations for 0.25 micrometers features indicate a depth of focus comparable to the Rayleigh limit (+/- 0.4 micrometers ) for a single-layer resist process and up to two times this value for near-surface-imaged resists. Focus latitudes greater than the Rayleigh limit are predicted for 0.18 micrometers features when using near-surface-imaged resists in conjunction with annular illumination.
Synthesis of Soluble Fluorinated Vinyl Ether Copolymers by Ionic Addition of Fluoroolefins to Poly(vinyl alcohol) (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSynthesis of Soluble Fluorinated Vinyl Ether Copolymers by Ionic Addition of Fluoroolefins to Poly(vinyl alcohol)Andrew E. Feiring and Edward R. WonchobaView Author Information DuPont Central Research & Development, Experimental Station, P.O. Box 80328, Wilmington, Delaware 19880-0328 Cite this: Macromolecules 1998, 31, 20, 7103–7104Publication Date (Web):September 9, 1998Publication History Received12 May 1998Revised28 July 1998Published online9 September 1998Published inissue 1 October 1998https://pubs.acs.org/doi/10.1021/ma980755ehttps://doi.org/10.1021/ma980755ebrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views365Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Ethers,Ketones,Optical properties,Polymers Get e-Alerts
Degree Day Method (2004)

Abstract An adequate description and prediction of plant development is critical for understanding plant growth and its responses to the environment. Only then we can assess the impact of a changing environment on plant productivity and survival, understand plant adaptation, design adequate agricultural production systems, and optimize natural resources management. Of particular importance for water resource management are the effects of plant ontogeny on plant water use and productivity throughout the regulation of leaf area. This determines the patterns of plant water demand and the partitioning between transpiration and evaporation components. Therefore, plant development dictates the selection of cultivars that best fit the water availability patterns under dryland conditions, and the amount, frequency and timing for irrigation otherwise.
Studying the Past for the Future: Managing Modern Biodiversity from Historic and Prehistoric Data (2010)

Management of biodiversity and anthropogenic effects on the environment are some of the most difficult challenges facing humans today. In this paper, we describe how archaeological, historical, and ecological data can be combined to identify metrics of ecological change. Archaeological surveys, historic witness tree data, analysis of ancient pollen, and recent satellite imagery are combined to create indicators of change that are useable by modern environmental managers at Fort Benning Military Reservation in Georgia and Alabama in the United States. Archaeological data were collected at 30 meter intervals, historic vegetation data were collected from early nineteenth century survey maps, and ancient pollen and charcoal were collected from soil cores in lakes. We show how data sets collected with disparate goals from anthropology and ecology can be applied to make policy decisions about environmental management.
Kaposi’s sarcoma-associated herpesvirus vIRF2 protein utilizes an IFN-dependent pathway to regulate viral early gene expression (2019)

Kaposi's sarcoma-associated herpesvirus (KSHV; human herpesvirus 8) belongs to the subfamily of Gammaherpesvirinae and is the etiological agent of Kaposi's sarcoma as well as of two lymphoproliferative diseases: primary effusion lymphoma and multicentric Castleman disease. The KSHV life cycle is divided into a latent and a lytic phase and is highly regulated by viral immunomodulatory proteins which control the host antiviral immune response. Among them is a group of proteins with homology to cellular interferon regulatory factors, the viral interferon regulatory factors 1-4. The KSHV vIRFs are known as inhibitors of cellular interferon signaling and are involved in different oncogenic pathways. Here we characterized the role of the second vIRF protein, vIRF2, during the KSHV life cycle. We found the vIRF2 protein to be expressed in different KSHV positive cells with early lytic kinetics. Importantly, we observed that vIRF2 suppresses the expression of viral early lytic genes in both newly infected and reactivated persistently infected endothelial cells. This vIRF2-dependent regulation of the KSHV life cycle might involve the increased expression of cellular interferon-induced genes such as the IFIT proteins 1, 2 and 3, which antagonize the expression of early KSHV lytic proteins. Our findings suggest a model in which the viral protein vIRF2 allows KSHV to harness an IFN-dependent pathway to regulate KSHV early gene expression.
Iron Management in Hemodialysis Patients: Optimizing Outcomes in Vicenza, Italy (2003)

The management of anemia in uremic patients undergoing hemodialysis requires the appropriate combination of erythropoietin treatment, iron supplementation, and on occasion androgen therapy. Identifying and correcting functional iron deficiency is crucial to optimizing erythropoietin efficiency. Recently, however, the trend to administer maintenance iron with resultant high serum ferritin and high transferrin saturation has led to an increase in reports of iron overload. Oral iron supplementation is inexpensive and safe, but poor patient compliance and reduced intestinal absorption may limit its efficacy. Intravenous iron, on the other hand, is effective, and its safety is related to the iron salt used. Currently available data suggest that iron saccharate may be the safest iron salt available for intravenous administration, although iron gluconate is safer than the dextran forms of intravenous iron. It should be kept in mind, however, that all forms of intravenous iron may have the potential of inducing iron overload. At this time, the levels of ferritin that define iron overload are not clearly established. The side effects of iron overload are well recognized (infections, malignancies, vascular diseases); however, no guidelines exist for safe practice. There are many markers of iron deficiency, with serum ferritin and hypochromic red cell percentage currently the best markers available in clinical practice.
Decrease in transforming growth factor beta 1 binding during differentiation of rat adipocyte precursors in primary culture. (1991)

Transforming growth factor beta 1 (TGF-beta 1) binding and action were investigated during differentiation of adipocyte precursors freshly isolated from rat inguinal fat-pad cultivated in defined medium. The data presented in this paper indicate that TGF-beta 1 inhibits differentiation of adipocyte precursors with a 50% effective dose of 9 pM. Time course experiments demonstrate that TGF-beta 1 is active only when it is added to the cells while they are still undifferentiated. If added after the cells have started to differentiate, TGF-beta 1 is less active or becomes inactive. 125I-TGF-beta 1 binding studies on adipocyte precursors before and after differentiation indicate a 10-fold decrease in the number of TGF-beta 1 binding sites after the cells have differentiated. Blocking of the differentiation process by treating the cells with fetal bovine serum or with prostaglandin F2 alpha prevented the decrease in the number of TGF-beta 1 receptors, thereby demonstrating that this change in binding was specifically linked to the differentiation process. Experiments cross-linking 125I-TGF-beta 1 to adipocyte precursors showed that 125I-TGF-beta 1 is specifically cross-linked to two bands with molecular weights of 92,000 and 70,000. After differentiation, a decrease in the intensity of the cross-linked bands was observed. These results demonstrate that loss of cell surface TGF-beta 1 binding sites follows differentiation of adipocyte precursors.
Distinguishing Lesions from Posterior Acoustic Shadowing in Breast Ultrasound via Non-Linear Dimensionality Reduction (2006)

Breast ultrasound (US) in conjunction with digital mammography has come to be regarded as the gold standard for breast cancer diagnosis. While breast US has certain advantages over digital mammography, it suffers from image artifacts such as posterior acoustic shadowing (PAS), presence of which often obfuscates lesion margins. Since classification of lesions as either malignant or benign is largely dictated by lesion's shape and margin characteristics, it is important to distinguish lesion area from PAS. This paper represents the first attempt to extract and identify those image features that can help distinguish between lesion and PAS. Our methodology comprises of extracting over 100 statistical, gradient, and Gabor features at multiple scales and orientations at every pixel in the breast US image. Adaboost, a powerful feature ensemble technique is used to discriminate between lesions and PAS by combining the different image features. A non-linear dimensionality reduction method called Graph Embedding is then used to visualize separation and inter-class dependencies between lesions and PAS in a lower dimensional space. Results of quantitative evaluation on a database of 45 breast US images indicate that our methodology allows for greater discriminability between the lesion and PAS classes compared to that achievable by any individual image texture or intensity feature.
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules (2015)

The central nervous system (CNS) is considered an organ devoid of lymphatic vasculature. Yet, part of the cerebrospinal fluid (CSF) drains into the cervical lymph nodes (LNs). The mechanism of CSF entry into the LNs has been unclear. Here we report the surprising finding of a lymphatic vessel network in the dura mater of the mouse brain. We show that dural lymphatic vessels absorb CSF from the adjacent subarachnoid space and brain interstitial fluid (ISF) via the glymphatic system. Dural lymphatic vessels transport fluid into deep cervical LNs (dcLNs) via foramina at the base of the skull. In a transgenic mouse model expressing a VEGF-C/D trap and displaying complete aplasia of the dural lymphatic vessels, macromolecule clearance from the brain was attenuated and transport from the subarachnoid space into dcLNs was abrogated. Surprisingly, brain ISF pressure and water content were unaffected. Overall, these findings indicate that the mechanism of CSF flow into the dcLNs is directly via an adjacent dural lymphatic network, which may be important for the clearance of macromolecules from the brain. Importantly, these results call for a reexamination of the role of the lymphatic system in CNS physiology and disease.
Treatment of Adult Scoliosis Fractional Curve With Minimally Invasive Surgery: Anterior Versus Posterior Approach? (2019)

INTRODUCTION: The fractional curve in adult scoliosis often causes radiculopathy and may be managed in varied manners with minimally invasive (MIS) deformity correction. There are inherent risks and benefits to anterior and posterior interbody reconstruction techniques, and the purpose of this study was to evaluate for differences in outcomes or complication rates by fractional curve treatment via MIS anterior vs. posterior interbody fusion METHODS: Inclusion criteria were age = 18 yr, and one of the following: coronal cobb > 20°, SVA > 5 cm, PT > 20°, PI-LL > 10°. Patients were treated with circumferential MIS (cMIS) surgery or hybrid MIS surgery and had 2-yr minimum follow-up. Patient were divided into two groups: anterior or posterior interbody fusion at the lumbosacral junction (L4-S1). HRQOL measures included Oswestry Disability Index (ODI), visual analog score (VAS). RESULTS: A total of 112 patients who underwent MIS adult deformity surgery with minimum 2-yr follow up. A total of 74 patients underwent anterior and 38 patients underwent posterior interbody reconstruction at L4-S1 utilizing MIS technique. Preoperative spinopelvic parameters, radiographic parameters, and VAS were not different, but ODI was higher in the anterior group (53 vs 48, P = .047). Complications and reoperation rates were not different (P = .089, P = .597), but posterior had more infections (15.8% vs 2.7%, P = .01). When subdivided for cMIS only surgery, 38 had anterior and 19 underwent posterior interbody fusions in the fractional curve. Pre- and postoperative VAS leg, ODI, and fractional curve magnitude were not different. In the anterior surgery cohorts, laminectomies at L4-S1 were performed in 22% of hybrid cases and in 8% of cMIS cases. CONCLUSION: Treatment of the fractional curve of adult scoliosis appears to be similarly effective in reducing VAS, ODI, and fractional curve magnitude regardless of anterior vs posterior approach. However, posterior interbody reconstruction was associated with higher infection rate than anterior, regardless of application in cMIS or hybrid technique.
ChemInform Abstract: Studies on the Enantiospecific Synthesis of Oxindole Alkaloids. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.