gebhart/patrepeval huggingface dataset:
Advanced interference suppression receiver for LTE-advanced systems (2013)

Co-channel interference is considered as one of the most important issues of modern wireless communication systems. In order to address the interference issue in LTE-A systems, the linear interference rejection combining (IRC) receiver was introduced. Inter-cell interference suppression in the IRC receiver is provided via simple beam forming on the antenna elements of the receiver, which are calculated using the estimated interference covariance matrix. During the related LTE Rel-11 study item in the 3GPP RAN1 Working Group, the IRC receiver was identified as a promising mechanism for improving the cell-edge user throughput. However, for interfering links employing MIMO schemes with multiple spatial layers or in the case of more than one dominant interfering node, the interference suppression capability of the linear IRC receivers is substantially reduced. In this paper we investigate the performance of advanced non-linear IRC receiver structures for interference suppression. More specifically, we propose a maximum-likelihood detection (MLD) scheme to suppress more than one dominant interfering links. The simulation results show that the proposed MLD receiver structure, employing additional knowledge about the modulation scheme of the interfering layers, improves the cell-edge user throughput (defined as the 5 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> percentile value of the cumulative distribution function) by approximately 23% compared to the baseline linear IRC receiver.
A compact UWB MIMO antenna with inverted U-shaped slot for WLAN rejection (2017)

A compact Ultra-Wideband (UWB) MultipleInput Multiple-Output (MIMO) antenna prototype is proposed in this paper. The proposed prototype is designed using Rogers 4533, which has dielectric constant of 3.3. Radiating patch of both antennas is loaded with an inverted U-shaped slot to notch upper WLAN band. Isolation for whole UWB band is achieved using modified ground plane, while keeping both radiating elements close to each other. Parametric analysis is also presented in this paper along with other results. Results for S-parameter and radiation pattern prove that this antenna is good candidate for UWB MIMO systems.
Optical power distributions through fractal routing (2014)

Several applications in integrated optics require an equal distribution of power from a single input port among many photonic components, whether they be projection components or sensors. One method of achieving such a system is through using progressively more tightly coupled evanescent couplers to route power from a single feeding line [1]. While very compact, this approach requires careful design and characterization of evanescent couplers, and is vulnerable to process variations as the ratio of coupling has a non-linear relation to the couplers’ gap size. Fractals, widely present in nature, are recursive objects where each section is geometrically similar to its parent. They find applications in various fields [2], including RF antenna design and feeding [3]. In this paper we propose to use the fractal approach for spreading power evenly over an area using micro-machined photonic waveguides. In the fractal routing demonstrated in this work, an 1&times;2 multimode interference (MMI) coupler splits the power at each fractal stage. This provides several advantages. First, only one power splitter design is needed. Second, MMI couplers are well known, and more robust to process tolerances than evanescent couplers [3]. Third, they are symmetrical, and therefore provide a theoretically perfect power distribution independent of the fractal depth. We therefore demonstrate that a fractal routing provides a way to evenly and efficiently distribute power over a large area.
Thermal Behavior of Ferroelectric Switching Properties of SBT Thin Films (2002)

The thermal behavior of the charge properties of a Sr 0.8 Bi 2.2 Ta 2 O 9 (SBT) thin film was investigated in a range from 300 K to 559 K. The thermal behaviors of the ferroelectric switching charge and the coercive electric field for the SBT film were well explained according to the Landau-Devonshire theory.
Data from "Cavity-enhanced coherent light scattering from a quantum dot" (2016)

Data used in the figure presented in the publication "Cavity-enhanced coherent light scattering from a quantum dot."
Integrated mutational landscape analysis of uterine leiomyosarcomas (2021)

Uterine leiomyosarcomas (uLMS) are aggressive tumors arising from the smooth muscle layer of the uterus. We analyzed 83 uLMS sample genetics, including 56 from Yale and 27 from The Cancer Genome Atlas (TCGA). Among them, a total of 55 Yale samples including two patient-derived xenografts (PDXs) and 27 TCGA samples have whole-exome sequencing (WES) data; 10 Yale and 27 TCGA samples have RNA-sequencing (RNA-Seq) data; and 11 Yale and 10 TCGA samples have whole-genome sequencing (WGS) data. We found recurrent somatic mutations in TP53, MED12, and PTEN genes. Top somatic mutated genes included TP53, ATRX, PTEN, and MEN1 genes. Somatic copy number variation (CNV) analysis identified 8 copy-number gains, including 5p15.33 (TERT), 8q24.21 (C-MYC), and 17p11.2 (MYOCD, MAP2K4) amplifications and 29 copy-number losses. Fusions involving tumor suppressors or oncogenes were deetected, with most fusions disrupting RB1, TP53, and ATRX/DAXX, and one fusion (ACTG2-ALK) being potentially targetable. WGS results demonstrated that 76% (16 of 21) of the samples harbored chromoplexy and/or chromothripsis. Clinically actionable mutational signatures of homologous-recombination DNA-repair deficiency (HRD) and microsatellite instability (MSI) were identified in 25% (12 of 48) and 2% (1 of 48) of fresh frozen uLMS, respectively. Finally, we found olaparib (PARPi; <i>P</i> = 0.002), GS-626510 (C-MYC/BETi; <i>P</i> < 0.000001 and <i>P</i> = 0.0005), and copanlisib (PIK3CAi; <i>P</i> = 0.0001) monotherapy to significantly inhibit uLMS-PDXs harboring derangements in C-MYC and PTEN/PIK3CA/AKT genes (LEY11) and/or HRD signatures (LEY16) compared to vehicle-treated mice. These findings define the genetic landscape of uLMS and suggest that a subset of uLMS may benefit from existing PARP-, PIK3CA-, and C-MYC/BET-targeted drugs.
ChemInform Abstract: A New and Selective Catalyst for the [5 + 2] Cycloaddition of Vinylcyclopropanes and Alkynes. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Platelet Aggregation Inhibitory Activity of Selective A2 Adenosine Receptor Agonists (1995)

Abstract A series of new 2-alkynyl, 2-cycloalkynyl, and 2-aralkynyl derivatives of adenosine-5′-ethyluronamide (NECA) were synthesized and evaluated in binding studies and functional assays to assess their potency and selectivity at A2 vs A1 receptors. The new derivatives were also tested as inhibitors of rabbit platelet aggregation induced by ADP. While the presence of an aromatic or heteroaromatic ring conjugated to the triple bond decreased antiplatelet activity, the introduction of a hydroxyl group or a heterocyclic ring on the alkynyl side chain increased the antiaggregatory activity in comparison with NECA, resulting in the most potent inhibitors of platelet aggregation so far known in the nucleoside series. However, the presence of an α-quaternary carbon markedly reduced the antiaggregatory potency without affecting the A2 binding affinity, suggesting that the platelet receptor is not a typical A2a site.
Reciprocal Space Signals Arising from Interference of Core-Loss Electrons in the EMCD Geometry (2011)

Extended abstract of a paper presented at Microscopy and Microanalysis 2011 in Nashville, Tennessee, USA, August 7–August 11, 2011.
Evaluation of a polymerase chain reaction reverse hybridization line probe assay for the detection and identification of medically important fungi in bronchoalveolar lavage fluids (2003)

An assay system in which polymerase chain reaction (PCR) amplification of the ITS-1 region of ribosomal DNA (rDNA) is combined with a reverse-hybridization line probe assay (LiPA) was used for the identification of six Candida species and four Aspergillus species in pure cultures of clinical isolates, as well as in bronchoalveolar lavage (BAL) fluid samples from 42 patients with various underlying diseases. The results were compared with the results obtained with conventional routine identification methods as well as with a commercial enzyme-linked immunosorbent assay (ELISA) galactomannan detection assay and an Aspergillus-specific PCR. No discrepancies between the PCR-LiPA system and routine methods were found for pure cultures of Candida and Aspergillus species except in the case of Aspergillus versicolor. In BAL fluid samples in which Candida species were cultured, the PCR-LiPA system identified more species than did the routine methods. When routine analyses of patient samples were supplemented by adding data obtained by repurifying and re-identifying cultures and by taking isolates obtained from other body sites into account, the results agreed with PCR-LiPA system results in 81% of the cases (34/42). Most of the remaining discrepancies (6/8) involved cases in which such supplementary data were not available. In BAL fluid samples from which A. fumigatus was cultured, the agreement between the PCR-LiPA system and the routine methods was low. Only 2 of 11 BAL samples shown to contain A. fumigatus in ELISA and genus-specific PCR assays were positive in PCR-LiPA system. The PCR-LiPA system enables the simultaneous detection and identification of different fungal species present in pure or mixed populations within 6 h in a single assay. Optimization is required, however, before it is useful as a diagnostic tool in the clinical microbiology laboratory.
All-solid-state high-power conduction-cooled Nd:YLF rod laser (2000)

A high-average-power conduction-cooled diode-pumped Nd:YLF rod laser has been developed. A new conduction-cooled side-pumping scheme with a solid prismatic pump-light confinement cavity was employed. A transparent, high-thermal-conductivity MgF>(2) prism was used as a highly efficient pump cavity as well as a low-thermal-resistance heat spreader. The pumping efficiency and thermal resistance of the cavity were 85% and 0.20 degrees C degrees W, respectively. When this scheme was combined with heat pipes for heat removal, a maximum average output power of 72 W was demonstrated, with an optical slope efficiency as high as 49%.
Derived Nominals (2010)

Abstract This chapter extends the theory of argument structure proposed earlier to derived nominals and shows that, despite differences between sentential and nominal structures, both feature the same basic argument categories. It examines how Affectee arguments are realized in the nominal system and argues that certain classic problems such as the Affectedness Constraint can be insightfully reframed within the proposed approach. The chapter also analyzes non-event nominals in English and their interaction with compounding, showing that only one type of nominal corresponds to each of the argument categories Agent, Theme, and Affectee. Such nominals are formed by derivational affixes that are simply realizations of the argument categories themselves. The chapter concludes by implying that derivational morphology and compounding are fundamentally syntactic in nature.
A Loop-Free Interface-Based Fast Reroute Technique (2008)

Nowadays, providing reliable network services is getting more and more important. However, traditional failure recovery methods in IP networks are typically reactive, therefore restoration often takes a long time. One of the most interesting solutions is interface-based fast rerouting, where not only the destination address but the incoming interface too is taken into consideration during forwarding packets in normal state and upon rerouting after a failure. Unfortunately, current methods are prone to form routing loops during the recovery process, which might make parts of the network unaffected by the failure unavailable. In this paper, we propose a new interface-based routing method, which always avoids loops at the price of a bit longer paths. We also present extensive simulation results to compare the traditional and our proposed algorithms.
Evaluation of the radiolabeled human recombinant mini-antibody 131I-L19SIP in patients (pts) with cancer: Results of a phase I/II study. (2010)

e13054 Background: The human recombinant antibody L19 selectively binds to the angiogenesis-related and tumor stroma-associated antigen extradomain B (ED-B) fibronectin. 131I-L19SIP is being investigated in a clinical trial in pts with solid cancer to define the maximum tolerated dose for a single application. Methods: All pts had failed multiple therapies and had recurrent and progressive disease at enrollment. A tracer amount of 131I-L19SIP (185 MBq or 5 mCi) was administered for biodistribution and dosimetry evaluation. Whole-body, spot, and SPECT/CT images were acquired at different time points after 131I-L19SIP injection. Three cohorts of pts were scheduled to receive 4107 MBq/m2(111 mCi/m2), 5143 MBq/m2 (139 mCi/m2), and 6167 MBq/m2 (167 mCi/m2) of 131I-L19SIP. Post-therapy planar whole-body and SPECT/CT images were obtained 8–12 days post- administration of the therapeutic dose to confirm specific tumor targeting. Results: 12 pts (7 men, 5 women; mean age 58.1±7.2 yr) were enrolled: NSCLC (4), mesothelioma (3), thymoma (2), head and neck cancer (1), uveal melanoma (1), ovarian adenocarcinoma (1). Based on selective uptake into tumor lesions (lesion/background ratio ≥4) 10 pts were eligible for the therapeutic 131I-L19SIP dose and 7 pts have received treatment (2 pts excluded because of disease progression between the diagnostic and therapeutic phase; 1 pt awaiting therapy). No dose-limiting toxicity observed so far, with the first dose cohort closed and the second actively recruiting. Transient grade 1–4 thrombocytopenia and grade 2–4 lymphocytopenia were observed in all the cases between weeks 1 and 5, with spontaneous recovery; no other systemic or organ-specific toxicity was observed. Sequential [18F]FDG-PET/CT at 2 months after therapy demonstrated significant reduction in size and intensity of [18F]FDG uptake in 1 pt, stable disease in 5 pts, and progressive disease in 1 pt. Conclusions: Preliminary data indicate that ED-B fibronectin is a promising target for the antibody-based delivery of therapeutic agents in pts with solid cancer. A single 131I-L19SIP administration of up to 5143 MBq/m2 is well tolerated. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Bayer Schering Pharma, Philogen SpA Philogen SpA Bayer Schering Pharma, Philogen SpA Philogen SpA Bayer Schering Pharma
Enabling Efficient Multi-Layer Repair in Elastic Optical Networks by Gradually Superimposing SDN (2016)

Multi-layer resilience is one of the prominent new concepts for modern carrier networks; it efficiently combines the advantages of the optical and the packet layer. However, not all features offered by modern optical transport networks can be fully used by the packet layer yet. In case of a fiber cut, an optical protection mechanism restores the original IP topology after a short transient time. But such an optical restoration is expected to use a new, longer light-path, which in turn might affect the optical capacity of the link. Bit-rate flexible optical transceivers are able to utilize the remaining optical capacity efficiently by adapting the network link capacity accordingly. However, the packet layer is not able to cope with fluctuating link capacities; often the policy is to rather shut down the link completely instead of using the remaining capacity. Consequently, this paper proposes a Segment Routing-based approach with superimposed Software-defined Networking (SDN) to allow the IP network to benefit from these new features. The minimally invasive, gradual deployment of the system is investigated, while keeping other proven and resilient technologies and systems unmodified. Using the topology and traffic matrix of a large German carrier the feasibility of such a deployment is evaluated.
Real-Time Optimal Energy Management of Heavy Duty Hybrid Electric Vehicles (2013)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The performance of energy flow management strategies is essential for the success of hybrid electric vehicles (HEVs), which are considered amongst the most promising solutions for improving fuel economy as well as reducing exhaust emissions. The heavy duty HEVs engaged in cycles characterized by start-stop configuration has attracted widely interests, especially in off-road applications. In this paper, a fuzzy equivalent consumption minimization strategy (F-ECMS) is proposed as an intelligent real-time energy management solution for heavy duty HEVs. The online optimization problem is formulated as minimizing a cost function, in terms of weighted fuel power and electrical power. A fuzzy rule-based approach is applied on the weight tuning within the cost function, with respect to the variations of the battery state-of-charge (SOC) and elapsed time. Comparing with traditional real-time supervisory control strategies, the proposed F-ECMS is more robust to the test environments with rapid dynamics. The proposed method is validated via simulation under two transient test cycles, with the fuel economy benefits of 4.43% and 6.44%, respectively. The F-ECMS shows better performance than the telemetry ECMS (T-ECMS), in terms of the sustainability of battery SOC.&lt;/div&gt;&lt;/div&gt;
Coexisting Few-Layer Assemblies of NiO and MoO3 Deposited on Vulcan Carbon as an Efficient and Durable Electrocatalyst for Water Oxidation (2019)

An efficient electrocatalyst for oxygen evolution reaction (OER) has been prepared by adopting a strategy wherein layered assembly of NiO and MoO3 could be dispersed on a Vulcan carbon support to simultaneously maintain exposure of the synergistically activated sites and electrical conductivity of the matrix. The assembly involves growth of layers of NiO on the surface of few-layer MoO3, which in turn is dispersed on Vulcan carbon (NiO@MoO3/VC) through a sequential hydrothermal process. The hydrothermal process played a key role in establishing the coexisting few-layer assembly of NiO and MoO3 on Vulcan carbon, which involved conversion of preformed MoS2 sheets to MoO3 and concomitant growth of Ni(OH)2 layer prior to its conversion to NiO during the subsequent heat treatment process. The NiO sheets have exposed edges, and they are instrumental in enhancing the OER activity of NiO@MoO3/VC. The higher activity is also credited to the lower charge transfer resistance (RCT) value possessed by NiO@MoO3/VC, which arises from the optimum combination of MoO3 and Vulcan carbon in the system. The overpotential of NiO@MoO3/VC for achieving the 10 mA cm–2 current density is 280 mV, which is an improved value over the 292 mV obtained in the case of the state-of-the-art RuO2 catalyst. NiO@MoO3/VC also demonstrates outstanding stability for 15 h in 1 M KOH solution at 1.51 V. The presence of surface nickel molybdate (NiMoO4) prevents the dissolution of MoO3 in the alkaline environment and provides excellent stability to the NiO@MoO3/VC in 1 M KOH solution.
Left ventricular failure induced by myocardial infarction. II. Tissue morphometry (1985)

Three days after myocardial infarction involving 57% of the left ventricle in rats, the viable tissue of the left ventricle expanded 29%, whereas myocardial hypertrophy in the right ventricle was 19%. To determine whether tissue oxygenation in the hypertrophied ventricles was supported by a proportional growth of the capillary network, morphometric analysis was used to measure capillary luminal volume and surface densities and the diffusion distance for O2. The volume fraction of capillary lumen and the luminal surface of capillaries, related to O2 availability and diffusion, were altered by -21 and -19%, respectively, in the left ventricle and by -23 and -20%, respectively, in the right ventricle. The path length for O2 transport was found to be increased by 12 and 15% in the left and right ventricle, respectively. In contrast, myocyte mass expanded in proportion to tissue growth in the left ventricle and exceeded tissue growth by 5% in the right ventricle. Myocyte mitochondria and myofibrils both grew in proportion to the cells, so that their volume ratio was not changed in either ventricle. The relatively inadequate adaptation of the capillary vasculature suggests that hypertrophy after severe myocardial infarction may initially leave the heart more vulnerable to additional ischemic episodes.
In Vivo Imaging of β-Galactosidase Activity Using Far Red Fluorescent Switch (2004)

beta-Galactosidase (beta-gal) has been widely used as a transgene reporter enzyme, and several substrates are available for its in vitro detection. The ability to image beta-gal expression in living animals would further extend the use of this reporter. Here we show that DDAOG, a conjugate of beta-galactoside and 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one) (DDAO), is not only a chromogenic beta-gal substrate but that the cleavage product has far-red fluorescence properties detectable by imaging. Importantly, the cleavage substrate shows a 50-nm red shift, enabling its specific detection in a background of intact probe, a highly desirable feature for in vivo imaging. Specifically, we show that beta-gal-expressing 9L gliomas are readily detectable by red fluorescence imaging in comparison with the native 9L gliomas. We furthermore show that herpes simplex virus amplicon-mediated LacZ gene transfer into tumors can be transiently and thus serially visualized over time. The results indicated that in vivo real-time detection of beta-gal activity is possible by fluorescence imaging technology.
Topical Inserts: A Versatile Delivery Form for HIV Prevention (2019)

The development of topical inserts for the prevention of sexually transmitted infections (STIs), particularly human immunodeficiency virus (HIV), represents a promising alternative to oral and parenteral pre-exposure prophylaxis (PrEP) dosage forms. They may be used for vaginal and/or rectal administration of a variety of agents with antiviral activity. Topical inserts deliver drugs to the portal of viral entry, i.e., the genital or rectal mucosa, with low systemic exposure, and therefore are safer and have fewer side effects than systemic PrEP agents. They may dissolve fast, releasing the active drugs within minutes of insertion, or slowly for long-acting drug delivery. Furthermore, they are user-friendly being easy to administer, discreet and highly portable. They are also economical and easy to manufacture at scale and to distribute, with excellent stability and shelf-life. Altogether, topical inserts represent a particularly promising form of drug delivery for HIV and STI prevention. Highlighted within this review are end-user acceptability research dedicated to understanding preferred attributes for this form of drug delivery, advantages and disadvantages of the formulation platform options, considerations for their development, clinical assessment of select placebo prototypes, future directions, and the potential impact of this dosage form on the HIV prevention landscape.