gebhart/patrepeval huggingface dataset:
Patients Discharged to Inpatient Rehabilitation Facilities Undergo More Diagnostic Interventions With No Improvement in Outcomes (2018)

The purpose of this study was to determine if there is a difference in the number of diagnostic tests and interventions, pain and function scores, or satisfaction of patients discharged to inpatient rehabilitation facilities vs to home. From February to May 2015, 171 consecutive patients were prospectively recruited following primary total knee arthroplasty. Six weeks postoperatively, based on the patients' recollections, the number and types of diagnostic imaging tests, number of blood transfusions, and overall satisfaction whether discharged to inpatient rehabilitation facilities (n=85) or to home (n=86) were assessed. A significantly greater proportion of patients discharged to inpatient rehabilitation facilities reported undergoing at least 1 diagnostic imaging test compared with patients discharged to home (25.9% vs 8.1%; P=.013). Multivariate logistic regressions revealed that patients discharged to an inpatient rehabilitation facility were more likely to have a greater number of diagnostic tests (odds ratio, 5.01; 95% confidence interval, 1.69-14.92; P=.004) and radiographs (odds ratio, 16.10; 95% confidence interval, 1.54-169.70; P=.020) performed. There was no significant difference in readmission rates for patients discharged to home (2.3%) vs to an inpatient rehabilitation facility (0%) (P=.246). No significant differences were observed in postoperative Knee Society pain or function scores (P=.083 and P=.057, respectively) or visual analog scale satisfaction scores (P=.206). Twenty-nine (34.1%) patients were discharged under the care of the visiting nurse service after leaving the rehabilitation facility. Patients discharged to an inpatient rehabilitation facility underwent more diagnostic testing, especially radiographs, than patients discharged to home. There were no clinically relevant differences in Knee Society pain or function scores or patient satisfaction. [Orthopedics. 2018; 41(6):e841-e847.].
Supplementary Table 3 from Immutable Functional Attributes of Histologic Grade Revealed by Context-Independent Gene Expression in Primary Breast Cancer Cells (2023)

Supplementary Table 3 from Immutable Functional Attributes of Histologic Grade Revealed by Context-Independent Gene Expression in Primary Breast Cancer Cells
Nitric oxide modulation of central imidazoline I1 receptors accounts for the hypertensive effect of cyclosporine in rats (2008)

This study tested the hypothesis that the hypertensive action of cyclosporine (CSA) involves interaction with central α 2 ‐receptors and/or I 1 ‐imidazoline receptors and investigated the role of nitric oxide in the interaction. The effect of clonidine (mixed α 2 /I 1 ‐receptor agonist), moxonidine (I 1 ‐receptor agonist), or guanabenz (α 2 ‐receptor agonist) on CSA hypertension was assessed in conscious rats. CSA (20 mg/kg i.v.) increased BP that continued for at least 45 min. CSA hypertension was inhibited by ganglionic (hexamethonium) or α 1 ‐receptor (prazosin) blockade. Pressor responses to phenylephrine were not affected by CSA, thereby eliminating a possible role for α 1 ‐receptors in CSA hypertension. Intravenous guanabenz (30 μg/kg), clonidine (30 μg/kg), or moxonidine (100 μg/kg) produced similar decreases in BP. Pretreatment with clonidine or moxonidine attenuated CSA hypertension whereas guanabenz had a minimal effect, suggesting a predominant role for I 1 ‐receptor neuronal pathways in the BP effect of CSA. Central administration of moxonidine (80 nmol) into cisterna magna also attenuated CSA hypertension. NOS inhibition by N G ‐nitro‐L‐arginine methyl ester abolished BP responses to moxonidine and CSA. Conclusion: facilitation of central I 1 ‐receptor‐NO signaling accounts, at least partly, for CSA hypertension. Supported by Faculty of Pharmacy, Univ. of Alexandria, Egypt.
Controlling the selectivity of bimetallic platinum–ruthenium nanoparticles supported on N-doped graphene by adjusting their metal composition (2021)

Bimetallic platinum–ruthenium nanoparticles supported on N-doped graphene as chemoselective hydrogenation catalysts.
A patch-slot combination approach for large band reflectarrays (2012)

This paper presents a new passive phase-shifting cell for reflectarray. It permits to loop back to its initial state after a whole theoretically 360° phase cycle. After optimization, a nearly 360° phase range is provided with a frequency dispersion less than 45°/GHz over a nearly 57% bandwidth. A complete analysis of the cycle is given supported with an equivalent electrical circuit.
Operation of a single-ended 550 Mbit/s, 41 fJ, hybridCMOS/MQWreceiver-transmitter (1996)

A single-ended, asynchronous, transimpedance receiver-transmitter circuit with 5 mW power dissipation, is implemented in 0.8 µm silicon CMOS. A hybrid flip-chip bonding technique is used to attach GaAs-AlGaAs MQW detectors and modulators to the circuit. Operation of the circuit at a sensitivity of –19.4 dBm (41 fJ) and a bit error rate &lt;10-9 at 550 Mbit/s is demonstrated.
Radical Intermediates and Antioxidants: An Esr Study of Radicals Formed on Carnosic Acid in the Presence of Oxidized Lipids (1994)

Carnosic acid, an antioxidant extracted from rosemary, is shown to produce radicals when in contact with oxidized methyl oleate in the absence of air above 50 degrees C. Two radical species are formed: the first one, stable up to approximately 110 degrees C, is an hydroxy-phenoxy radical whose ESR spectrum was analyzed by studying its temperature dependence and its sensitivity to deuterium/proton exchange. The second species was observed above 110 degrees C, its ESR spectrum was identical to the spectrum obtained when carnosol, another antioxidant extracted from rosemary, was heated at the same temperature in the presence of oxidized lipid. This observation is probably due to the transformation of carnosic acid into carnosol; the analysis of the corresponding ESR spectrum suggests the formation of a keto phenoxy radical exhibiting a great delocalization of the unpaired electron.
Crystal structure of trans-dichlorobis(dimesityltelluride)palladium(II), C72H88Cl4Pd2Te4 (2002)

Article Crystal structure of trans-dichlorobis(dimesityltelluride)palladium(II), C72H88Cl4Pd2Te4 was published on December 1, 2002 in the journal Zeitschrift für Kristallographie - New Crystal Structures (volume 217, issue JG).
Calcium Content and Force of Drug-Induced Contractions of Arterial Muscle During Recovery in vitro (1970)

Studies were designed, using rabbit aortic strips, to investigate the possible role calcium (Ca2+) ions play in the recovery of depressed, drug-induced contractions of excised, isolated blood vessels. The present experiments demonstrated that: (i) excision of aorta from intact rabbits and the subsequent surgical preparation and incubation of helical strips, at physiologic temperature in vitro, severely impairs the development of full sensitivity, of these aortic smooth muscle cells, to a variety of vasoactive substances for a period of 3 hr. (ii) A close relationship was found to exist between the ability or inability of different vasoactive drugs (e.g., epinephrine, histamine, potassium, and barium) to induce a maximal contractile response and the total Ca2+ content (as quantitatively determined by atomic absorption spectrophotometry). And (iii) mechanical (surgical) injury may alter the in vivo Ca2+ content of arterial smooth muscle.
Perioperative Complications After Surgical Correction in Neuromuscular Scoliosis (2007)

Patients with neuromuscular scoliosis are at high risk of developing perioperative complications after surgical correction of their deformity (overall rate, 33.1%).
Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease (2020)

Genotypes of CHD may account for increased cancer risks. In this cohort, damaging variants were prominent in the 216 genes that predominantly encode regulatory proteins. Consistent with their fundamental developmental functions, patients with CHD and damaging variants in these genes often had extracardiac manifestations. These data may also implicate cancer risk genes that are repeatedly varied in patients with unexplained CHD as CHD genes.
Novel Cyclic Compounds as Potent Phosphodiesterase 4 Inhibitors (1998)

The synthesis and biological activity of a novel series of 2, 2-disubstituted indan-1,3-dione-based PDE4 inhibitors are described. This structurally unique class of PDE4 inhibitors is markedly different from the known PDE4 inhibitors such as RP 73401 (2) and CDP 840 (3). Structure-activity relationship (SAR) studies led to the identification of inhibitors with nanomolar potency and oral activity in a murine endotoxemia model for TNF-alpha inhibition. Unlike other classical PDE4 inhibitors, several analogues were found to be nonemetic in a canine emesis model at intravenous doses of up to 3 mg/kg.
Role of CYP epoxygenases in A2AAR-mediated relaxation using A2AAR-null and wild-type mice (2008)

We hypothesized that A2A adenosine receptor (A2A AR) activation causes vasorelaxation through cytochrome P-450 (CYP) epoxygenases and endothelium-derived hyperpolarizing factors, whereas lack of A2A AR activation promotes vasoconstriction through Cyp4a in the mouse aorta. Adenosine 5'-N-ethylcarboxamide (NECA; 10(-6) M), an adenosine analog, caused relaxation in wild-type A2A AR (A2A AR+/+; +33.99 +/- 4.70%, P < 0.05) versus contraction in A2A AR knockout (A2A AR(-/-); -27.52 +/- 4.11%) mouse aortae. An A2A AR-specific antagonist (SCH-58261; 1 microM) changed the NECA (10(-6) M) relaxation response to contraction (-35.82 +/- 4.69%, P < 0.05) in A2A AR+/+ aortae, whereas no effect was noted in A2A AR(-/-) aortae. Significant contraction was seen in the absence of the endothelium in A2A AR+/+ (-2.58 +/- 2.25%) aortae compared with endothelium-intact aortae. An endothelial nitric oxide synthase inhibitor (N-nitro-L-arginine methyl ester; 100 microM) and a cyclooxygenase inhibitor (indomethacin; 10 microM) failed to block NECA-induced relaxation in A2A AR+/+ aortae. A selective inhibitor of CYP epoxygenases (methylsulfonyl-propargyloxyphenylhexanamide; 10 microM) changed NECA-mediated relaxation (-22.74 +/- 5.11% at 10(-6) M) and CGS-21680-mediated relaxation (-18.54 +/- 6.06% at 10(-6) M) to contraction in A2A AR+/+ aortae, whereas no response was noted in A2A AR(-/-) aortae. Furthermore, an epoxyeicosatrienoic acid (EET) antagonist [14,15-epoxyeicosa-5(Z)-enoic acid; 10 microM] was able to block NECA-induced relaxation in A2A AR+/+ aortae, whereas omega-hydroxylase inhibitors (10 microM dibromo-dodecenyl-methylsulfimide and 10 microM HET-0016) changed contraction into relaxation in A2A AR(-/-) aorta. Cyp2c29 protein was upregulated in A2A AR+/+ aortae, whereas Cyp4a was upregulated in A2A AR(-/-) aortae. Higher levels of dihydroxyeicosatrienoic acids (DHETs; 14,15-DHET, 11,12-DHET, and 8,9-DHET, P < 0.05) were found in A2A AR+/+ versus A2A AR(-/-) aortae. EET levels were not significantly different between A2A AR+/+ and A2A AR(-/-) aortae. It is concluded that CYP epoxygenases play an important role in A2A AR-mediated relaxation, and the deletion of the A2A AR leads to contraction through Cyp4a.
A Video Compression-Based Approach To Measure Music Structural Similarity. (2013)

[TODO] Add abstract here.
Nano-Characterization of Type-G Cement Slurry Incorporating Nanoclay Cured Under High Temperature and Pressure (2016)

Type-G cement slurry with various admixtures commonly used in oil/gas well cementing (OWC) incorporating 1, 2 and 3% nanoclay particles by weight of cement were produced. A water/cement ratio of 0.44 was used and the mixes were subjected to a temperature of 290 F and a pressure of 4666 psi for 48 hours. First, the effect of nanoclay on compressive strength evolution was investigated. Second elastic and viscoelastic characteristics of the cementitious mixes were characterized using nanoindentation. The nanoindentation tests enabled evaluating the maximum indentation depth, plastic depth, and the reduced elastic modulus. Furthermore, dwell time of 60 seconds was used to evaluate creep compliance of the cement mixes incorporating nanoclay. Fracture toughness was estimated from the nanoindentation data during the dwell loading period. Scanning electron microscope (SEM) and X-ray diffraction (XRD) microstructural analyses were conducted to explain the results observed using nanoindentation. Furthermore, finite element modeling was used to simulate the nanoindentation test and to extract the stress-strain Type-G cement material incorporating nanoclay and cured under high temperature and pressure. Moreover, The experimental observations showed that nanoclay improved compressive strength evolution with time compared with neat cement and eliminated strength retrogression problem. Furthermore, using 1 and 2% nanoclay resulted in insignificant change (-28 to +12%) of the reduced elastic modulus compared with neat cement. However, a high content of 3% nanoclay resulted in a significant increase of (+54%) in the reduced elastic modulus and a significant reduction in creep compliance compared with neat cement. Fracture analysis of nanoindentation data showed a significant improvement of fracture toughness due to the addition of nanoclay. XRD analysis and SEM investigations proved that the incorporation of nanoclay in the cement mix transforms the Calcium Hydroxide (CH) to calcium silicate hydrate (C-S-H) and reduced capillary porosity leading to higher elastic modulus and reduced creep compliance compared with neat cement. Finally, the extracted stress-strain curves using the finite element method shows that adding nanoclay resulted in stiffening OWC paste. The significance of nanoclay seems strongly dependent on the nanoclay content and the quality of its mixing with cement.
Nitrate uptake by p-phosphonic acid or p-(trimethylammonium)methyl calix[8]arene stablized laminar materials (2014)

Graphite, BN, MoS<sub>2</sub> and WS<sub>2</sub> are exfoliated and stablized in water with positively or negatively charged non-toxic calix[8]arenes. All 2D materials adsorb nitrate from waste effluent, precipitating once nitrate is bound, and can be regenerated.
Topologically Dissociable Patterns of Development of the Human Cerebral Cortex (2015)

Over 90 years ago, anatomists noted the cortex is thinner in sulci than gyri, suggesting that development may occur on a fine scale driven by local topology. However, studies of brain development in youth have focused on describing how cortical thickness varies over large-scale functional and anatomic regions. How the relationship between thickness and local sulcal topology arises in development is still not well understood. Here, we investigated the spatial relationships between cortical thickness, folding, and underlying white matter organization to elucidate the influence of local topology on human brain development. Our approach included using both T1-weighted imaging and diffusion tensor imaging (DTI) in a cross-sectional sample of 932 youths ages 8–21 studied as part of the Philadelphia Neurodevelopmental Cohort. Principal components analysis revealed separable development-related processes of regionally specific nonlinear cortical thickening (from ages 8–14) and widespread linear cortical thinning that have dissociable relationships with cortical topology. Whereas cortical thinning was most prominent in the depths of the sulci, early cortical thickening was present on the gyri. Furthermore, decline in mean diffusivity calculated from DTI in underlying white matter was correlated with cortical thinning, suggesting that cortical thinning is spatially associated with white matter development. Spatial permutation tests were used to assess the significance of these relationships. Together, these data demonstrate that cortical remodeling during youth occurs on a local topological scale and is associated with changes in white matter beneath the cortical surface.
Localized “Click” Chemistry Through Dip‐Pen Nanolithography (2007)

Local reactions are triggered by delivering molecules from an AFM probe tip, allowing for direct modification of chemically functionalized surfaces. Silicon wafer-bound acetylene moieties readily undergo 1,3-dipolar cycloadddition with solution-phase azides delivered from an AFM tip. This selective and robust technique allows for the facile creation and placement of sub-micrometer-sized features.
Telecare for Patients With Type 1 Diabetes and Inadequate Glycemic Control (2005)

We thank Biermann et al. (1) for their kind remarks about the clarity and importance of our research and for proposing a novel taxonomy of telecare interventions by purpose: as a supplement to usual care (A in their taxonomy) or as a replacement of face-to-face visits (sometimes called nonvisit encounters; B or C in their taxonomy).

Two of the trials included in our meta-analysis used, to some extent, telecare as replacement. In their 6-month trial, Chase et al. …
Immunisation with ‘naïve’ syngeneic dendritic cells protects mice from tumour challenge (2008)

Dendritic cells (DCs) 'pulsed' with an appropriate antigen may elicit an antitumour immune response in mouse models. However, while attempting to develop a DC immunotherapy protocol for the treatment of breast cancer based on the tumour-associated MUC1 glycoforms, we found that unpulsed DCs can affect tumour growth. Protection from RMA-MUC1 tumour challenge was achieved in C57Bl/6 MUC1 transgenic mice by immunising with syngeneic DCs pulsed with a MUC1 peptide. However, unpulsed DCs gave a similar level of protection, making it impossible to evaluate the effect of immunisation of mice with DCs pulsed with the specific peptide. Balb/C mice could also be protected from tumour challenge by immunisation with unpulsed DCs prior to challenge with murine mammary tumour cells (410.4) or these cells transfected with MUC1 (E3). Protection was achieved with as few as three injections of 50,000 naïve DCs per mouse per week, was not dependent on injection route, and was not specific to cell lines expressing human MUC1. However, the use of Rag2-knockout mice demonstrated that the adaptive immune response was required for tumour rejection. Injection of unpulsed DCs into mice bearing the E3 tumour slowed tumour growth. In vitro, production of IFN-gamma and IL-4 was increased in splenic cells isolated from mice immunised with DCs. Depleting CD4 T cells in vitro partially decreased cytokine production by splenocytes, but CD8 depletion had no effect. This paper shows that naïve syngeneic DCs may induce an antitumour immune response and has implications for DC immunotherapy preclinical and clinical trials.
Re: Inactivation of Androgen-Induced Regulator ARD1 Inhibits Androgen Receptor Acetylation and Prostate Tumorigenesis (2012)

No AccessJournal of UrologyInvestigative Urology1 Nov 2012Re: Inactivation of Androgen-Induced Regulator ARD1 Inhibits Androgen Receptor Acetylation and Prostate Tumorigenesis Anthony AtalaM.D. Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.07.065AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Inactivation of Androgen-Induced Regulator ARD1 Inhibits Androgen Receptor Acetylation and Prostate Tumorigenesis." The Journal of Urology, 188(5), pp. 2015–2016 © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 188Issue 5November 2012Page: 2015-2016 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Selective Direct Fluorination of Quinoline Derivatives. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
MicroRNAs: Redefining Mechanisms in Cardiac Disease (2010)

MicroRNAs (miRs) regulate protein expression by inhibiting translation of expressed mRNAs. Targeting by one or more miRs of multiple mRNA transcripts encoding proteins with common functions confers nodal control over cardiac development and stress response. Dynamic coregulation of miRs and their mRNA targets has complicated understanding their biology but also provides opportunities for clinical diagnostics and therapeutics. Here, the biology of miRs is reviewed as it relates to the cardiac system, recent findings are described that illuminate miR control of cardiac development and myofiber identity, and the clinical ramifications of miR expression profiling are illustrated.
Diffuse Histiocytic Lymphoma (1977)

Comments and Correction1 February 1977Diffuse Histiocytic LymphomaED CADMAN, M.D., J. R. BERTINO, M.D.ED CADMAN, M.D., J. R. BERTINO, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-2-244 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: At Yale we have treated 30 patients who had stage III or IV diffuse histiocytic lymphoma with a combination of cyclophosphamide, 1.5 g/m2intravenously on Day 1; vincristine, 2 mg intravenously weekly X 3; followed by methotrexate (MTX), 80 to 120 mg/m2intravenously weekly X 8 with leucovorin rescue beginning at 24 h; and cytosine arabinoside (cytarabine), 300 mg/m2intravenously with each MTX dose (COMA). In a few patients the MTX-cytosine arabinoside was given for 3 weeks only. The sequence was repeated three or more times for a total treatment period of 9 months. The median survival...Reference1. BERDCORNOGDORFMAN DJR: Long term remission in diffuse histiocytic lymphoma treated with combination sequential chemotherapy. Cancer 35:1050-1054, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: School of Medicine Yale University 333 Cedar Street New Haven, CT 06510 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByKlinik der malignen Lymphome 1 February 1977Volume 86, Issue 2Page: 244-245KeywordsComaCyclophosphamideCytosineDiffuse large B-cell lymphomaMethotrexate Issue Published: 1 February 1977 PDF DownloadLoading ...