gebhart/patrepeval huggingface dataset:
Becoming musically enculturated: effects of music classes for infants on brain and behavior (2012)

Musical enculturation is a complex, multifaceted process that includes the development of perceptual processing specialized for the pitch and rhythmic structures of the musical system in the culture, understanding of esthetic and expressive norms, and learning the pragmatic uses of music in different social situations. Here, we summarize the results of a study in which 6-month-old Western infants were randomly assigned to 6 months of either an active participatory music class or a class in which they experienced music passively while playing. Active music participation resulted in earlier enculturation to Western tonal pitch structure, larger and/or earlier brain responses to musical tones, and a more positive social trajectory. Furthermore, the data suggest that early exposure to cultural norms of musical expression leads to early preferences for those norms. We conclude that musical enculturation begins in infancy and that active participatory music making in a positive social setting accelerates enculturation.
Reactivity of Electrolyte with the Surface of 5-Volts Positive Electrode Materials for Li-Ion Batteries (2014)

We examine the reactivity of the non-aqueous electrolyte at the surface of 5-volts positive electrode materials for Li-ion batteries. LiPF 6 -based electrolytes include various solutes as ethylene carbonate (EC), dimethyl carbonate (DMC), diethyl carbonate (DEC) and 1,2-dimethoxyethane (DME), which react with the surface of LiNi 0.5 Mn 1.5 O 4 in the voltage range 3.0–4.9 V vs. Li 0 /Li + . Effects with mixed salts and electrolyte additive are also examined.
Targeted Cancer Immunotherapy by Nanoparticle T Cell Engagers (2022)

Introduction Acute myeloid leukemia (AML) is the most common type of leukemia. Emerging immunotherapies such as chimeric antigen receptor T (CAR‐T) cells and T cell engagers (TCEs), have the potential to enhance T cell recognition and response against cancers, but come with serious limitations such as short half‐life, complex production, high cost, and inability to customize for another antigen. To overcome these limitations, we previously developed a nanoparticle‐based T cell engagers (nanoTCEs) technology that has a longer half‐life (60h vs 2h for TCEs), is convenient to make, easily customizable, and robustly activates T cells for cancer killing. In this study, we hypothesized that nanoTCEs targeting CD33/CD3 would effectively activate T cell response in an AML disease model. Material and Methods Liposomes were produced via the thin‐film hydration method with cholesterol, DPPC, and DSPE‐PEG200 at a molar ratio of 30:65:5 respectively ( Figure 1A ). CD33/CD3 nanoTCEs were created by conjugating anti‐CD3 and anti‐CD33 monoclonal antibodies (mAbs) on liposome surface with streptavidin‐biotin chemistry. Liposome binding to human T cells and AML cell lines was performed with fluorescently labeled nanoTCEs for 2 hours. The activation of T cell subsets and killing of AML cell lines was analyzed by flow cytometry after 4 days in a 3D culture model. For in vivo efficacy, immunodeficient NCG mice were inoculated with AML cell line and received Isotype/CD3 or CD33/CD3 nanoTCEs injections (0.5 mg/mouse) weekly and monitored for tumor progression and survival. Results AML cell lines (K052, MOLM‐14. NOMO‐1, and THP‐1) exhibited high expression of CD33 compared to controls. CD33/CD3 nanoTCEs bound to human T cells and AML cell lines with higher specificity than isotype controls. In addition, the CD33/CD3 nanoTCEs induced increased activation of both CD4+ and CD8+ T cells ( Figure 1B, 1C ) and achieved greater AML killing compared to the untreated and Isotype/CD3 groups ( Figure 1D ). Lastly, our in vivo results showed that weekly CD33/CD3 nanoTCE injections extended survival and decreased tumor progression of AML bearing mice compared to Isotype/CD3 nanoTCEs treated mice. By day 66 of the in vivo study, none of the Isotype/CD3 cohort was alive, while 100% of the CD33/CD3 cohort remained living ( Figure 2 ). Discussion and Conclusion This study shows that nanoTCEs are a promising novel platform for immunotherapy in AML. CD33/CD3 nanoTCEs demonstrated specific engagement of T cells to AML cells, which induced T cell activation and AML cell killing both in vitro and in vivo . It not only circumvented the limitations of traditional T cell engagers, but also presented numerous advantages such as short production time, low cost, and superior pharmacokinetic profile. Moreover, this technology is highly customizable and can be tailored to target multiple cancer antigens simultaneously. The current findings provide a strong preclinical basis for future first‐in‐human clinical trials of CD33/CD3 nanoTCEs as a novel AML immunotherapy.
A Multimodal Sensing Ring for Quantification of Scratch Intensity (2023)

An objective measurement of chronic itch is necessary for improvements in patient care for numerous medical conditions. While wearables have shown promise for scratch detection, they are currently unable to estimate scratch intensity, preventing a comprehensive understanding of the effect of itch on an individual. In this work, we present a framework for the estimation of scratch intensity in addition to the detection of scratch. This is accomplished with a multimodal ring device, consisting of an accelerometer and a contact microphone, a pressure-sensitive tablet for capturing ground truth intensity values, and machine learning algorithms for regression of scratch intensity on a 0-600 milliwatts (mW) power scale that can be mapped to a 0-10 continuous scale. We evaluate the performance of our algorithms on 20 individuals using leave one subject out cross-validation and using data from 14 additional participants, we show that our algorithms achieve clinically-relevant discrimination of scratching intensity levels. By doing so, our device enables the quantification of the substantial variations in the interpretation of the 0-10 scale frequently utilized in patient self-reported clinical assessments. This work demonstrates that a finger-worn device can provide multidimensional, objective, real-time measures for the action of scratching.
Total plasma heme concentration increases after red blood cell transfusion and predicts mortality in critically ill medical patients (2019)

Total plasma heme concentration increases in critically ill patients after RBC transfusion and is independently associated with mortality. This transfusion-associated increase in total plasma heme is not fully explained by RBC unit storage age or cell-free heme content. Additional studies are warranted to define mechanisms of transfusion-related plasma heme accumulation and test prevention strategies.
Development of Standardized and Competency-Based Curriculum in Nursing Informatics (2007)

Objective: The purposes of this study were to analyze the current status of nursing informatics course and to develop the standardized curriculum in nursing informatics course based on competency. Methods: Data were collected through two phases. In the first phase, a survey was conducted on 115 nursing institutions to analyze the current status of nursing informatics course. In the second phase, two-round delphi technique was developed to determine the priority and relative weight of contents in nursing informatics course. Final samples composed of both 43 nursing institutions and 11 nursing informatics experts. Results: Out of 43 nursing schools, 13 nursing schools offered nursing informatics course. Nursing informatics was taught mostly to the second year and had 2 credits. About 54% of respondents disagreed that nursing informatics should be included in the license examination for Registered Nurse. The subject matrix by priority and relative weight and a standardized curriculum for nursing informatics were developed. Conclusion: Continuous application and revision of nursing informatics curriculum should be needed. (Journal of Korean Society of Medical Informatics 13-3, 227-236, 2007)
Pre-Microporation Improves Outcome of Pancreatic Islet Labelling for Optical and 19F MR Imaging (2017)

For labelling of pancreatic islets using poly(lactic-co-glycolic acid) nanoparticles, the modified microporation procedure with low voltage was found to be safer than the standard microporation procedure. The modified procedure was fast, however, efficiency was lower compared to endocytosis.
An Extensible Markup Language (XML)-Based Format for Event Notification Filtering (2006)

The SIP event notification framework describes the usage of the
Session Initiation Protocol (SIP) for subscriptions and notifications
of changes to a state of a resource. The document does not describe a
mechanism whereby filtering of event notification information can be
achieved. Filtering is a mechanism for defining the preferred
notification information to be delivered and for specifying triggers
that cause that information to be delivered. In order to enable this,
a format is needed to enable the subscriber to describe the state
changes of a resource that cause notifications to be sent to it and
what those notifications are to contain. This document presents a
format in the form of an XML document. [STANDARDS-TRACK]
Brief report: validity of Finnish registry‐based diagnoses of autism with the ADI‐R (2010)

These results suggest that the validity of Finnish registry-based diagnoses of childhood autism can be considered good. Our findings lay important groundwork for further population- based studies of the aetiology of autism.
Molecular dynamics study of particle–particle collisions between hydrogen-passivated silicon nanoparticles (2004)

One of the significant challenges in the use of nanoparticles is the control of primary particle size and extent of agglomeration when grown from the gas phase. In this paper we evaluate a possible strategy of surface passivation. Here the particle--particle interaction of hydrogen-surface-terminated silicon nanoparticles has been evaluated using molecular dynamics simulation. Nanoparticles of the size between 200 and 6400 silicon atoms at 300--1800 K were studied with a reparametrized Kohen-Tully-Stillinger empirical interatomic potential. A hydrogen monolayer is shown to prevent coalescence between particles under thermal collision conditions. The critical approach energy for coalescence was found to increase with increasing particle size but decreases with increasing temperature. Both solid and liquid droplets were seen to bounce at thermal energies, and in some cases, ``superelastic'' collisions are observed, where the rebound kinetic energy of the droplet is higher than the approach energy. These results suggest that surface coatings can significantly retard nanoaerosol growth.
Time Effects in the Electrodeposition of CoPt Magnetic Alloys (2009)

Electroplating of magnetic alloys is often the preferred method of fabrication of micropermanent magnets for microelectromechanical system applications. Electroplated cobalt–platinum alloys have the desired magnetic characteristics. However, the observed current efficiency, the composition, and the magnetic properties of the deposit change with the amount of charge passed. This impedes the manufacturability of alloys. These changes are undoubtedly associated with changes in the composition of the bath, specifically the nature of the Pt-containing complex. Here we discuss the possible changes in the complex and in the other components of the bath, employing the methods of voltammetry.
Role of Hepcidin in the Setting of Hypoferremia during Acute Inflammation (2013)

The anemia of chronic disease (also called anemia of inflammation) is an acquired disorder of iron homeostasis associated with infection, malignancy, organ failure, trauma, or other causes of inflammation. It is now widely accepted that induction of hepcidin expression in response to inflammation might explain the characteristic hypoferremia associated with this condition. To determine the role of hepcidin in acute inflammation and the regulation of its receptor, the iron exporter, ferroportin, wild-type, heterozygote and hepcidin knockout mice (Hepc-/-) were challenged with sublethal doses of lipopolysaccharide (LPS). Six hours after injection, ferroportin mRNA and protein levels were assessed in the duodenum and the spleen and plasma iron was determined. Our results demonstrate that hepcidin is crucial, though not the sole mediator of LPS-mediated acute hypoferremia, and also that hepcidin major contribution relies on decreased ferroportin protein levels found in the spleen. Furthermore, we establish that LPS-mediated repression of the membrane iron transporter DMT1 and oxidoreductase Dcytb in the duodenum is independent of hepcidin. Finally, our results in the hepc+/- mice indicate that elevated hepcidin gene expression is not a prerequisite for the setting of hypoferremia during early inflammatory response, and they highlight the intimate crosstalk between inflammatory and iron-responsive pathways for the control of hepcidin.
The enol-keto trigger in initiating arene diradical formation in calicheamicin/esperamicin analogs (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe enol-keto trigger in initiating arene diradical formation in calicheamicin/esperamicin analogsM. F. Semmelhack, J. J. Gallagher, T. Minami, and T. DateCite this: J. Am. Chem. Soc. 1993, 115, 24, 11618–11619Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/ja00077a079https://doi.org/10.1021/ja00077a079research-articleACS PublicationsRequest reuse permissionsArticle Views262Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Fourth-order dispersion-limited solitary pulses (1994)

We analyze the performance of a Ti:sapphire self-mode-locked laser with near-zero second- and third-order dispersion. Our simulations show that, in the presence of fourth-order dispersion, solitary laser pulses can be supported within a wide parameter range, close to the experimental values of these parameters. We also conclude that it is possible to generate pulses much shorter than 10 fs if fourth-order dispersion is further reduced.
Telomerase Regulation and Telomere‐Length Homeostasis (2012)

This chapter contains sections titled: Introduction Telomerase Regulation at Telomeres in Yeast Post-Translational Regulation of Mammalian Telomerase Concluding Remarks References
Microstructure and Magnetic Properties of Cu-Co Alloys by Severe Plastic Deformation (2005)

Recent studies have shown that magnets processed by serve plastic deformation could achieve a high coercivity due to the grain refinement Dilute alloys of Cu-Co system are unique, since small ferromagnetic Co precipitates are formed in non-magnetic Cu matrix during the aging process. The objective of the present investigation is to clarify how one of severe plastic deformation techniques, namely Equal-Channel Angular Pressing (ECAP) [2], can improve the magnetic properties of a Cu-1.8wt.% Co-0.2wt.% Cr containing ferromagnetic precipitates.
Optimization of highly efficient mode converter for coupling light into large-slot photonic crystal waveguide (2014)

We demonstrate a highly efficient mode converter for coupling light into a silicon slotted photonic crystal waveguide with slot width as large as 320nm. The loss of the mode converter is measured to be 0.08dB.
C# Language Specification (2003)

C# is a simple, modern, object-oriented, and type-safe programming language that combines the high productivity of rapid application development languages with the raw power of C and C++. Written by the language's architect and design team members, The C# Programming Language is the definitive technical reference for C#. Moving beyond the online documentation, the book provides the complete specification of the language along with descriptions, reference materials, and code samples from the C# design team.The first part of the book opens with an introduction to the language to bring readers quickly up to speed on the concepts of C#. Next follows a detailed and complete technical specification of the C# 1.0 language, as delivered in Visual Studio .NET 2002 and 2003. Topics covered include Lexical Structure, Types, Variables, Conversions, Expressions, Statements, Namespaces, Exceptions, Attributes, and Unsafe Code.The second part of the book provides an introduction to and technical specification of the four major new features of C# 2.0: Generics, Anonymous Methods, Iterators, and Partial Types.Reference tabs and an exhaustive print index allow readers to easily navigate the text and quickly find the topics that interest them most. An enhanced online index allows readers to quickly and easily search the entire text for specific topics.With the recent acceptance of C# as a standard by both the International Organization for Standardization (ISO) and ECMA, understanding the C# specification has become critical. The C# Programming Language is the definitive reference for programmers who want to acquire an in-depth knowledge of C#.0321154916B10142003
Altered metabolism in cancer (2010)

Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its relation to energy production in cancer cells. A recent study in BMC Systems Biology by Vasquez et al. developed a mathematical model to assess some features of this altered metabolism. Here, we take a broader look at the regulation of energy metabolism in cancer cells, considering their anabolic as well as catabolic needs. See research article: http://www.biomedcentral.com/1752-0509/4/58/
Accessibility of the Highly Conserved Amino- and Carboxy-Terminal Regions from HIV-1 External Envelope Glycoproteins (1989)

Amino- and carboxy-terminal extremities of the envelope external glycoproteins are regions that have remained highly conserved between human immunodeficiency viruses HIV-1 and HIV-2. The corresponding peptides have been synthesized and their structure and function analyzed. Circular dichroism spectra showed evidence of alpha helical conformation when the peptides were dissolved in the nonpolar solvent trifuoroethanol. These two regions are indeed exposed on the molecule because they were accessible to their respective specific antibodies on the native gp160 precursor or processed gp120 glycoproteins of HIV-1. Neither the peptides nor rabbit or human antibodies directed against the N- and C-terminal peptides interfered with the interaction between HIV-1 external glycoprotein gp120 and its CD4 cellular receptor. Taken together, these results indicate that N- and C-terminal regions of gp120 are accessible on the quaternary structure of the virion as well as on the soluble form of gp120 and that these regions are not directly or indirectly involved in the binding of gp120 to CD4.
Microbial reduction of metal-organic frameworks enables synergistic chromium removal (2019)

Redox interactions between electroactive bacteria and inorganic materials underpin many emerging technologies, but commonly used materials (e.g., metal oxides) suffer from limited tunability and can be challenging to characterize. In contrast, metal-organic frameworks exhibit well-defined structures, large surface areas, and extensive chemical tunability, but their utility as microbial substrates has not been examined. Here, we report that metal-organic frameworks can support the growth of the metal-respiring bacterium Shewanella oneidensis, specifically through the reduction of Fe(III). In a practical application, we show that cultures containing S. oneidensis and reduced metal-organic frameworks can remediate lethal concentrations of Cr(VI) over multiple cycles, and that pollutant removal exceeds the performance of either component in isolation or bio-reduced iron oxides. Our results demonstrate that frameworks can serve as growth substrates and suggest that they may offer an alternative to metal oxides in applications seeking to combine the advantages of bacterial metabolism and synthetic materials.
Channel architecture optimization for performance and routability of row-based FPGAs (2002)

Considers routability and performance-driven optimization of a segmented channel architecture for row-based field programmable gate arrays (FPGAs). The routability of a channel and the performance of the routed circuit may have conflicting requirements. For a given number of tracks, very short segments usually enhance routability at the expense of performance. A simulated annealing-based channel segmentation optimization scheme has been developed, which enhances channel routability and performance based on the correlation between segment and net distributions. Excellent results have been obtained for a set of benchmark examples and industrial designs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Contribution of antibody response to recombinant HIV-1 gene-encoded products nef, rev, tat, and protease in predicting development of AIDS in HIV-1-infected individuals. (1991)

The relation between antibody-response profiles to Escherichia coli-produced HIV-1 nef, rev, tat, and protease proteins and the risk of developing AIDS was studied using stored serum samples taken sequentially from a cohort of 195 initially symptom-free men who were seropositive for antibodies to HIV-1 structural proteins and 72 men who seroconverted for such antibodies. The AIDS attack rates at 39 months follow-up were significantly higher in the men with negative versus positive antibody profiles to nef, tat, and protease, respectively. [Difference (D) between attack rates = 11.279, 5.884, and 8.322, respectively]. No significant difference was found between men with negative versus positive antibody profiles to rev. The above differences between AIDS attack rates were clearly lower than those reported from the same cohort for men who were serum HIV-1 antigen positive versus negative, and for men with low versus normal CD4+ lymphocyte counts, but with respect to nef antibody-response profiles, resembled the difference reported between anti-HIV-1 core antibody-negative versus antibody-positive men. In the subgroup of men without any of the markers previously found to be predictive of progression to AIDS in the cohort (persistent HIV-1 p24 antigenemia, low anti-HIV-1 anti-core antibody reactivity, and low CD4+ cell counts), antibody profiles to nef, rev, tat, and protease did not contribute to the prediction of outcome of infection. When used in combination with persistent HIV-1 p24 antigenemia and low CD4+ cell counts, negative antibody profiles to nef and protease, respectively, were equally sensitive and specific in predicting progression to AIDS, as was low anti-HIV-1 anti-core antibody reactivity.