gebhart/patrepeval huggingface dataset:
α- And β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ (2015)

We investigated the identities of the isoforms of the α (NaV1)- and β (NaVβ)-subunits of voltage-gated sodium channels, including those responsible for action potentials in rodent sciatic nerves. To examine α-subunits, we used seven μ-conotoxins, which target site 1 of the channel. With the use of exogenously expressed channels, we show that two of the μ-conotoxins, μ-BuIIIB and μ-SxIIIA, are 50-fold more potent in blocking NaV1.6 from mouse than that from rat. Furthermore, we observed that μ-BuIIIB and μ-SxIIIA are potent blockers of large, myelinated A-fiber compound action potentials (A-CAPs) [but not small, unmyelinated C-fiber CAPs (C-CAPs)] in the sciatic nerve of the mouse (unlike A-CAPs of the rat, previously shown to be insensitive to these toxins). To investigate β-subunits, we used two synthetic derivatives of the recently discovered μO§-conotoxin GVIIJ that define site 8 of the channel, as previously characterized with cloned rat NaV1- and NaVβ-subunits expressed in Xenopus laevis oocytes, where it was shown that μO§-GVIIJ is a potent inhibitor of several NaV1-isoforms and that coexpression of NaVβ2 or -β4 (but not NaVβ1 or -β3) totally protects against block by μO§-GVIIJ. We report here the effects of μO§-GVIIJ on 1) sodium currents of mouse NaV1.6 coexpressed with various combinations of NaVβ-subunits in oocytes; 2) A- and C-CAPs of mouse and rat sciatic nerves; and 3) sodium currents of small and large neurons dissociated from rat dorsal root ganglia. Our overall results lead us to conclude that action potentials in A-fibers of the rodent sciatic nerve are mediated primarily by NaV1.6 associated with NaVβ2 or NaVβ4.
Extraction of differences in deformation behavior during swing of shafts with different kick points (2021)

In playing the golf, using suitable golf club is important to put out high scores and hit the correct shot. Several studies have been conducted on good club choice and improved golf club performance. A good choice of golf club not only improves the shot, but also improves the feel. However, few studies have investigated the effect of changes in the physical properties of the club on the feel. Therefore, this study aims to clarify the factors that influence the feel when golfers swing shafts with different kick points. First, a golf club was modeled by a simulation model consisting of Euler-Bernoulli beams in order to calculate the deformation behavior of the shaft. Next, we performed a motion capture test to measure the grip movement of shafts with different kick points. We calculated the inertial force generated at each node from the measured grip movement and calculated the bending behavior by inputting it to the simulation model. Then, using the calculated bending behavior as an observation matrix, singular value decomposition was applied, and the main deformation behavior was calculated and compared. Finally, we were able to find common ground among testers who prefer high-kick points and identify behaviors that affect the feel.
First Impact Factor for ACS Sensors – 5.711 (2018)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
Inference in Multi-Layer Networks with Matrix-Valued Unknowns (2020)

We consider the problem of inferring the input and hidden variables of a stochastic multi-layer neural network from an observation of the output. The hidden variables in each layer are represented as matrices. This problem applies to signal recovery via deep generative prior models, multi-task and mixed regression and learning certain classes of two-layer neural networks. A unified approximation algorithm for both MAP and MMSE inference is proposed by extending a recently-developed Multi-Layer Vector Approximate Message Passing (ML-VAMP) algorithm to handle matrix-valued unknowns. It is shown that the performance of the proposed Multi-Layer Matrix VAMP (ML-Mat-VAMP) algorithm can be exactly predicted in a certain random large-system limit, where the dimensions $N\times d$ of the unknown quantities grow as $N\rightarrow\infty$ with $d$ fixed. In the two-layer neural-network learning problem, this scaling corresponds to the case where the number of input features and training samples grow to infinity but the number of hidden nodes stays fixed. The analysis enables a precise prediction of the parameter and test error of the learning.
Patterning the topographical environment for mammalian cell culture using laminar flows in capillaries (2002)

This paper describes the use of patterned flows of multiple laminar streams of etching solutions in capillaries to create various topographical features with sizes of 10-200 /spl mu/m in poly(dimethylsiloxane) (PDMS). A variety of topographical features were created by using channels with obstacles, by adjusting the flow rates of etchant, or by controlling the duration of etching. Bovine capillary endothelial cells aligned parallel to features when grown inside these topographically patterned capillaries with 10 /spl mu/m ridges. The capillaries with topographical features could also be further patterned with surface-attached red blood cells and surface-adsorbed proteins, using laminar flows. This two-stage patterning produces patterns of proteins and cells on the topography with alignment between the different features and patterns. The technique allows simultaneous micropatterning of multiple cell culture environments using the same capillary system.
Cathodoluminescence study of radiative interface defects in thermally grown SiO2/4H-SiC(0001) structures (2015)

Radiative defects in thermally grown SiO2/4H-SiC(0001) structures and their location in depth were investigated by means of cathodoluminescence spectroscopy. It was found that while luminescence peaks ascribed to oxygen vacancy and nonbridging oxygen hole centers were observed both from thermal oxides grown on (0001) Si-face and C-face surfaces as with thermal oxides on Si, intense yellow luminescence at a wavelength of around 600 nm was identified only from the oxide interface on the Si-face substrate regardless of the oxide thickness and dopant type. Possible physical origins of the radiative centers localized near an oxide interface of a few nm thick are discussed on the basis of visible light emission from Si backbone structures.
Privacy and Identity Management. Time for a Revolution?: 10th IFIP WG 9.2, 9.5, 9.6/11.7, 11.4, 11.6/SIG 9.2.2 International Summer School, Edinburgh (2016)

This book contains a range of keynote papers and submitted papers presented at the 10th IFIP WG 9.2, 9.5, 9.6/11.7, 11.4, 11.6/SIG 9.2.2 International Summer School, held in Edinburgh, UK, in August 2015. The 14 revised full papers included in this volume were carefully selected from a total of 43 submissions and were subject to a two-step review process. In addition, the volume contains 4 invited keynote papers. The papers cover a wide range of topics:cloud computing, privacy-enhancing technologies, accountability, measuring privacy and understanding risks, the future of privacy and data protection regulation, the US privacy perspective, privacy and security, the PRISMS Decision System, engineering privacy, cryptography, surveillance, identity management, the European General Data Protection Regulation framework, communicating privacy issues to the general population, smart technologies, technology users' privacy preferences, sensitive applications, collaboration between humans and machines, and privacy and ethics.
Fut2 genotype is a risk factor for dominant stenosis and biliary candida infections in primary sclerosing cholangitis (2014)

The rs601338-FUT2 genotype is strongly associated with episodes of cholangitis, fungobilia and the incidence of dominant stenosis, which are three clinical hallmarks of PSC; FUT2 is thus an important genetic risk factor for host-microbial diversity and disease progression in PSC.
Velocity estimation from offset VSPs using directPand convertedSV‐waves (1988)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1988Velocity estimation from offset VSPs using direct P and converted SV‐wavesAuthors: Cengiz EsmersoyCengiz EsmersoySchlumberger‐Doll Researchhttps://doi.org/10.1190/1.1892324 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1892324FiguresReferencesRelatedDetailsCited By8. Vertical Seismic Profiles through Gas-Hydrate-Bearing Sediments21 March 20103C–3D VSP vector wavefield separation with constrained inversionWenbo Sun, Sam Zandong Sun, and Haijun Bai14 October 20093D VSP P‐P and P‐SV waves imaging with Kirchhoff migration on fractured and caved carbonate reservoir in Tarim basinWenbo Sun, Zandong Sun, Shiying Wu, and Ximing Wang14 October 2009Wavefield separation for borehole acoustic reflection surveys using parametric inversionNobuyasu Hirabayashi, W. Scott Leaney, and Jakob B. U. Haldorsen15 December 2008 SEG Technical Program Expanded Abstracts 1988ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1988 Pages: 1359 publication data© 1988 Copyright © 1988 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Cengiz Esmersoy, (1988), "Velocity estimation from offset VSPs using direct P and converted SV‐waves," SEG Technical Program Expanded Abstracts : 538-541. https://doi.org/10.1190/1.1892324 Plain-Language Summary PDF DownloadLoading ...
Superchannel CPE with Wyner-Ziv Cooperation for Band-Limited Interconnects in Multi-DSP Receiver (2018)

We introduce Wyner-Ziv (WZ) cooperation between multiple subcarrier receivers for joint-channel carrier phase estimation (CPE) in optical superchannel transmissions. The WZ cooperation improves CPE performance by at least 0.25 dB when inter-chip connections are band-limited.
Supplementary Data from <i>In vivo</i> antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I (2023)

Supplementary Data from &lt;i&gt;In vivo&lt;/i&gt; antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I
Structure of putative tumor suppressor ALDH1L1 (2022)

Putative tumor suppressor ALDH1L1, the product of natural fusion of three unrelated genes, regulates folate metabolism by catalyzing NADP<sup>+</sup>-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO<sub>2</sub>. Cryo-EM structures of tetrameric rat ALDH1L1 revealed the architecture and functional domain interactions of this complex enzyme. Highly mobile N-terminal domains, which remove formyl from 10-formyltetrahydrofolate, undergo multiple transient inter-domain interactions. The C-terminal aldehyde dehydrogenase domains, which convert formyl to CO<sub>2</sub>, form unusually large interfaces with the intermediate domains, homologs of acyl/peptidyl carrier proteins (A/PCPs), which transfer the formyl group between the catalytic domains. The 4'-phosphopantetheine arm of the intermediate domain is fully extended and reaches deep into the catalytic pocket of the C-terminal domain. Remarkably, the tetrameric state of ALDH1L1 is indispensable for catalysis because the intermediate domain transfers formyl between the catalytic domains of different protomers. These findings emphasize the versatility of A/PCPs in complex, highly dynamic enzymatic systems.
Laryngeal Carcinoma Multivariate Analysis of Prognostic Factors in 1 252 Consecutive Patients Treated with Primary Radiotherapy (2003)

Multivariate analyses of prognostic factors were carried out in 1252 consecutive patients with laryngeal squamous cell carcinoma treated with primary radical radiotherapy. Ten percent of patients had positive neck nodes Most of the patients were in stage I (48%), the remainder in stage II (24%), III (18%) and IV (10%). Of these patients, 746/1 252 (60%) were controlled by primary treatment but 506/1 252 (40%) had residual tumor or recurrent disease. The larynx was preserved in 62% of patients. The 5-year actuarial values for disease-specific and overall survival were 78% and 60%, respectively. The results of a univariate analysis showed multiple significant prognostic factors, and in a Cox proportional hazards model it was found that gender and T-classification were significant for T-failure, locoregional failure, death from cancer and death from all causes. The region of origin, nodal involvement, differentiation and pretreatment hemoglobin value were significant for several of the above-mentioned endpoints. Laryngeal carcinoma is curable when treated with primary radiotherapy, and this treatment confers a high degree of organ preservation. Independent prognostic factors in the multivariate analyses were gender, region of origin, T-stage, nodal involvement, differentiation and hemoglobin.
A robot for heights (2013)

Corrosion of reinforcing steel adversely affects the durability and safety of our&#13;\ninfrastructure (bridges, power plants or buildings) with huge annual costs.&#13;\nTimely detection of corrosion could thus greatly reduce the costs of repair interventions.&#13;\nClimbing robots using vortex technology are able to adhere&#13;\nto vertical, inclined or even underside concrete surfaces. Therefore, the objective&#13;\nis to combine two state-of-the art technologies to create a climbing robot&#13;\nfor corrosion monitoring of reinforced concrete structures.
Case study: Simulating and measuring the vibration and radiated sound of a large industrial chiller (2022)

This paper presents a case study for measuring and simulating the vibration and radiated sound for a large complex industrial chiller. We describe a simulation framework based on statistical energy analysis (SEA), which is populated using a hybrid mix of analytic, numerical, and measurement techniques. This hybrid approach was motivated by preliminary measurements of vibration and sound from the operating chiller, as well as a series of vibroacoustic transfer functions measured during quiescent non-operating conditions. Some components, like the chiller condenser shell, are modally dense and well suited to statistical estimates of SEA parameters like modal density and coupling between the shell modes and internal and external acoustic spaces. Other components, like the discharge pipe between the compressor and condenser shell, have only a few well separated modes with low damping. This component is better modeled using mobilities either measured or calculated using finite element analysis. We estimate other parameters like internal and coupling loss factors using a mix of analytics and measurements where appropriate. We validate the general model by comparing simulated and measured transfer functions between the discharge pipe and condenser shell — the components that radiated the most sound. We estimate structure-borne and fluid-borne input powers from the compressor using inference techniques based on transfer function measurements at quiescent conditions and averaged surface vibrations measured at operating conditions. This inference approach allows for estimating input powers over any chiller operating condition. Simulated vibrations and radiated sound are generally within 3 dB of measurements for several operating conditions. This case study provides a useful general methodology for modeling and measuring the vibroacoustics of chillers and other complex machinery
Fudan at MediaEval 2013: Violent Scenes Detection Using Motion Features and Part-Level Attributes. (2013)

The Violent Scenes Detection Task of MediaEval provides a valuable platform for algorithm evaluation and performance comparison. This is a very challenging task as there exist many forms of violent scenes, which vary significantly in their visual and auditory clues. In this notebook paper, we describe our system used in MediaEval 2013, which focuses on the use of motion-based features and part-level semantic attributes. One of the key components of the system is a set of trajectory-based motion features that have been observed effective in last year’s evaluation. We also adopt a newly developed part-level attribute feature, which consists of detection scores of object and scene parts. Our results indicate that the trajectory-based motion features can still offer very competitive performance, and the attribute feature is also helpful under several situations. In addition, temporally smoothing detection scores can lead to a significant performance gain. We conclude that a successful violent scenes detection system should use truly multimodal features, ranging from motion-based to static visual descriptors, as well as audio and attribute features. 1.
Review of laser applications in glaucoma filtering surgery (1994)

Laser sclerostomy is currently being evaluated as an approach which can possibly provide a better means of controlling open angle glaucoma than by conventional filtering surgery. This article will introduce various laser systems and their applications in glaucoma filtering surgery.
DNA-Templated Assembly of Conducting Gold Nanowires between Gold Electrodes on a Silicon Oxide Substrate (2005)

Here we report on the DNA-templated self-assembly of conducting gold nanowires between gold electrodes lithographically patterned on a silicon oxide substrate. An aqueous dispersion of 4-(dimethylamino)pyridine-stabilized gold nanoparticles was prepared. These nanoparticles recognize and bind selectively double-stranded calf thymus DNA aligned between the gold electrodes to form a linear nanoparticle array. Continuous polycrystalline gold nanowires are obtained by electroless deposition that enlarges and enjoins the individual gold nanoparticles. The above nanowires were structurally characterized using a range of electron and scanning probe microscopies and electrically characterized at room temperature using a standard probe setup. The results of these characterizations show these wires to be 20 nm high and 40 nm wide, to be continuous between interdigitated gold electrodes with an interelectrode spacing of 0.2 or 1.0 μm, and to possess a resistivity of 2 × 10-4 Ωm. These DNA-templated nanowires, the smallest reported to date, exhibit resistivities consistent with reported findings and current theory. The use of DNA as a template for the self-assembly of conducting gold nanowires represents a potentially important approach to the fabrication of nanoscale interconnects.
Technical Note: Investigating the impact of field size on patient selection for the 1.5T MR‐Linac (2017)

The maximum radiation field size of the MR-Linac in the superior-inferior patient direction is 22 cm. With a 1 cm margin approximately 80% of all plans would be suitable for the MR-Linac with the available field size, decreasing to 61% for larger tumor volumes. For cervix patients this may motivate investigations into treating each CTV with a separate isocentre, allowing for careful control of matching fields.
Polymerization of Purified Yeast Septins: Evidence That Organized Filament Arrays May Not Be Required for Septin Function (2021)

The septins are a family of proteins required for cytokinesis in a number of eukaryotic cell types. In budding yeast, these proteins are thought to be the structural components of a filament system present at the mother–bud neck, called the neck filaments. In this study, we report the isolation of a protein complex containing the yeast septins Cdc3p, Cdc10p, Cdc11p, and Cdc12p that is capable of forming long filaments in vitro. To investigate the relationship between these filaments and the neck filaments, we purified septin complexes from cells deleted for CDC10 or CDC11. These complexes were not capable of the polymerization exhibited by wild-type preparations, and analysis of the neck region by electron microscopy revealed that the cdc10Δ and cdc11Δ cells did not contain detectable neck filaments. These results strengthen the hypothesis that the septins are the major structural components of the neck filaments. Surprisingly, we found that septin dependent processes like cytokinesis and the localization of Bud4p to the neck still occurred in cdc10Δ cells. This suggests that the septins may be able to function in the absence of normal polymerization and the formation of a higher order filament structure.
Aggregation of Poly(styrene)−Poly(ethylene oxide) Diblock Copolymer Monolayers at the Air−Water Interface (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteAggregation of Poly(styrene)−Poly(ethylene oxide) Diblock Copolymer Monolayers at the Air−Water InterfaceA. M. Gonçalves da Silva, A. L. Simões Gamboa, and J. M. G. MartinhoView Author Information Centro de Química Estrutural, and Centro de Química-Física Molecular, Complexo I, Instituto Superior Técnico, 1096 Lisboa Codex, Portugal Cite this: Langmuir 1998, 14, 18, 5327–5330Publication Date (Web):August 6, 1998Publication History Received26 January 1998Revised1 July 1998Published online6 August 1998Published inissue 1 September 1998https://pubs.acs.org/doi/10.1021/la980101zhttps://doi.org/10.1021/la980101zbrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views423Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Compression,Copolymers,Hysteresis,Interfaces,Isotherms Get e-Alerts
Chemical redox reactions in ES-MS: Study of electrode reactions (1995)

The authors previously demonstrated that chemical redox reactions can be used to ionize neutral commpounds for electrospray mass spectrometric (ES-MS) detection. Two different compounds, viz, C{sub 60}F{sub 48} and {beta}-carotene were used to demonstrate the utility of chemical redox reactions with on-line ES-MS for the elucidation of mechanisms of complicated electron transfer reactions and for the kinetic study of electrode reactions in which relatively short-lived intermediates are involved.