gebhart/patrepeval huggingface dataset:
<title>Improved Y<formula><inf><roman>2</roman></inf></formula>O<formula><inf><roman>3</roman></inf></formula>-ZrO<formula><inf><roman>2</roman></inf></formula> waveguide fiber optic sensor for measuring gas-flow temperature above 2000 degrees Celsius</title> (2002)

Although Y<SUB>2</SUB>O<SUB>3</SUB>-ZrO<SUB>2</SUB> fiber-optic sensor has been developed for contact measurement of temperature higher than 2000 degree(s)C, its performance is not as good as that of sapphire fiber-optic sensor below 1900 degree(s)C due to the large optical loss of the Y<SUB>2</SUB>O<SUB>3</SUB>-ZrO<SUB>2</SUB> fiber. In order to improve the Y<SUB>2</SUB>O<SUB>3</SUB>-ZrO<SUB>2</SUB> fiber-optic sensor for ultra-high-temperature applications, in this work, based on a newly developed rectangular Y2O3-ZrO2 single-crystal waveguide with much lower optical loss, an improved Y<SUB>2</SUB>O<SUB>3</SUB>-ZrO<SUB>2</SUB> waveguide-fiber-optic sensor has been developed. The sensor has been tested up to near 2300 degree(s)C, we estimate that, the improved sensor has similar performance as the sapphire fiber-optic sensor in accuracy and resolution, except the disadvantage of relatively short waveguide. In addition, in this work, instead of the previous volatile and toxic BeO-coated probe, we use a multi-ions-doped sensor head, which is much stable and safe.
Enforcing connectivity of 3D linear structures using their 2D projections (2022)

Many biological and medical tasks require the delineation of 3D curvilinear structures such as blood vessels and neurites from image volumes. This is typically done using neural networks trained by minimizing voxel-wise loss functions that do not capture the topological properties of these structures. As a result, the connectivity of the recovered structures is often wrong, which lessens their usefulness. In this paper, we propose to improve the 3D connectivity of our results by minimizing a sum of topology-aware losses on their 2D projections. This suffices to increase the accuracy and to reduce the annotation effort required to provide the required annotated training data. Code is available at https://github.com/doruk-oner/ConnectivityOnProjections.
<title>Force regulation in multiple-manipulator systems</title> (1992)

Despite the recent progress in the motion and force control of multiple manipulators, there has been a continuing question about which physical force should be and can be controlled. The frequently used orthogonal decomposition is plagued by a unit inconsistency problem, rendering its physical interpretation difficult if not impossible. This paper introduces a new and intuitively appealing concept of internal force, and shows how its regulation can be handled by the existing approaches.
Targeting of mTOR is associated with decreased growth and decreased VEGF expression in acute myeloid leukaemia cells (2009)

mTOR-targeting drugs exert antileukaemic effects on AML cells in vitro through multiple actions, including direct inhibition of proliferation, induction of apoptosis and suppression of VEGF. Based on this study and other studies, mTOR can be regarded as a potential drug target in AML.
Possible effect of landscape design on IgE recognition profiles of two generations revealed with micro‐arrayed allergens (2017)

The aim of this study was to investigate possible effects of landscape design on the IgE sensitization profile toward inhalant allergens in patients with respiratory allergy from Uzbekistan where green areas have been changed during the last two decades by a State program. Sera from two different generations of Uzbek (n=58) and, for control purposes, from two generations of Austrian (n=58) patients were analyzed for IgE reactivity to 112 different micro-arrayed allergen molecules by ImmunoCAP ISAC technology. Changes in molecular IgE sensitization profiles to pollen allergens in the young vs the middle-aged Uzbek population were associated with replanting, whereas those in the Vienna populations reflected natural changes in plant growth. Our data indicate that anthropologic as well as natural changes in the biome may have effects on IgE sensitization profiles already from one to another generation.
Personalized Cancer Therapy Prioritization Based on Driver Alteration Co-occurrence Patterns (2019)

Abstract Identification of actionable genomic vulnerabilities is the cornerstone of precision oncology. Based on a large-scale drug screening in patient derived-xenografts, we uncover connections between driver gene alterations, derive Driver Co-Occurrence (DCO) networks, and relate these to drug sensitivity. Our collection of 53 drug response predictors attained an average balanced accuracy of 58% in a cross-validation setting, which rose to a 66% for the subset of high-confidence predictions. Morevover, we experimentally validated 12 out of 14 de novo predictions in mice. Finally, we adapted our strategy to obtain drug-response models from patients’ progression free survival data. By revealing unexpected links between oncogenic alterations, our strategy can increase the clinical impact of genomic profiling.
A fuzzy logic controller view of participatory learning (2002)

The authors discuss the participatory learning model originally introduced by R.R. Yager (1990). They analyze the learning mechanism as a stable control strategy. It is shown that the learning mechanism used in participatory learning can be expressed in a rule base formulation. This rule base formulation is used to provide new learning rules. The Widrow-Hoff rule is modified to include a participatory learning mechanism.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Development of a Brain PET System, PET-Hat: A Wearable PET System for Brain Research (2011)

Brain functional studies using PET have advantages over fMRI in some areas such as auditory research in part because PET systems produce no acoustic noise during acquisition. However commercially available PET systems are designed for whole body studies and are not optimized for brain functional studies. We developed a low cost, small, wearable brain PET system named PET-Hat dedicated for brain imaging. It employs double counter-balanced systems for mechanical supports of the detector ring while allowing the subject some freedom of motion. The motion enables subject to be measured in the sitting position and move relatively freely with the PET during acquisition. The detector consists of a Gd <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> (GSO) block, a tapered light guide and a flat panel photomultiplier tube (FP-PMT). Two types of GSO are used for depth-of-interaction (DOI) separation allowing the use of a small ring diameter without resolution degradation. The tapered light guide allows the use of larger GSO blocks with fewer FP-PMTs. Sixteen detector blocks are arranged in a 280 mm diameter ring. Transaxial and axial field-of-view (FOV) are 20 cm and 4.8 cm, respectively. Energy resolution of the block detectors was ~15% full width at half maximum (FWHM) and timing resolution was ~4.6 ns FWHM. Transaxial resolution and axial resolution at the center of the FOV were ~4.0 mm FWHM and ~3.5 mm FWHM, respectively. Sensitivity was 0.7% at the center of the axial FOV. Scatter fraction was ~0.6. Hoffman brain phantom images were successfully obtained. We conclude that the PET-Hat is a promising, low cost, small, wearable brain PET system for brain functional studies.
Built-in Self Test of RF Transceiver SoCs: from Signal Chain to RF Synthesizers (2007)

Built-in self test techniques for local oscillator phase noise, RF front-end circuits, baseband building blocks and transceiver loop-back are described. CMOS implementation of integrated RF test components, including RF detectors and phase discriminators are introduced. These devices eliminate the need for expensive external test equipment. The presented test strategies can also be used at wafer-level for fault diagnosis, localization and yield estimation. Silicon characterization results verifying most of these techniques are provided.
A model based filtering technique for driver's heart rate monitoring using seat-embedded vibration sensors (2014)

In this paper we consider the driver's heart rate monitoring problem for safety driving. To detect the heart rate of the driver, we adopt seat-embedded piezoelectric sensors. This sensor measures the body vibration caused by the heart beat but the signal also contains the large amount of car body vibration according to the road conditions. For this problem, we propose a heart rate detection system based on the ARX model based filtering technique.
A portrait of Endoscopic retrograde cholangiopancreatography and endoscopic ultrasound training programs in Europe: Current practices and opportunities for improvement (2023)

This survey first provides an overview of ERCP/EUS training programs across Europe. It shows that there is adherence to international guidelines to a certain degree, but several gaps in the application process, use of simulators for training, training curriculum and assessment of performance have been recognized. Overcoming these shortcomings could serve as a basis for further improvement in ERCP/EUS training.
Content-based image retrieval of digitized histopathology in boosted spectrally embedded spaces (2015)

Our results suggest that BoSE could serve as an important tool for CBIR and classification of high-dimensional biomedical data.
The quantity and quality of α-gal-specific antibodies differ in individuals with and without delayed red meat allergy (2016)

Patients with delayed meat allergy display IgE and IgG Ab that selectively recognize the α-gal epitope on BGG. Their enhanced α-gal-specific IgE levels are accompanied by high levels of α-gal-specific IgG1 devoid of IgE-blocking activity. This subclass distribution is atypical for food allergies and distinct from natural α-gal IgG responses in nonallergic individuals.
Genetically Encoded Fluorescent Reporters of Histone Methylation in Living Cells (2004)

We report the design and characterization of two genetically encoded fluorescent reporters of histone protein methylation. The reporters are four-part chimeric proteins consisting of a substrate peptide from the N-terminus of histone H3 fused to a chromodomain (a natural methyllysine-specific recognition domain), sandwiched between a fluorescence resonance energy transfer (FRET)-capable pair of fluorophores, cyan fluorescent protein (CFP) and yellow fluorescent protein (YFP). Enzymatic methylation by a methyltransferase induces complexation of the methylated substrate peptide to the chromodomain, changing the FRET level between the flanking CFP and YFP domains. Reporters developed using the chromodomains from HP1 and Polycomb respond to enzymatic methylation at the lysine 9 and lysine 27 positions of histone H3, respectively, giving 60% and 28% YFP/CFP emission ratio increases in vitro or in single living cells. These reporters should be useful for studying gene silencing and X-chromosome inactivation with high spatial and temporal resolution in intact cells and may also aid in the search for conjectured histone demethylase activity.
POS-055 ESTIMATED VERSUS MEASURED GLOMERULAR FILTRATION RATE IN ACUTE DECOMPENSATED HEART FAILURE (2021)

In patients undergoing decongestive therapy for acute heart failure (AHF), endogenous filtration markers such as serum creatinine (SCr) or cystatin C (CysC) are used to monitor kidney function. We tested whether dynamics of endogenous filtration markers and estimated GFR (eGFR) based on these markers appropriately reflect changes of measured GFR (mGFR) patients with AHF.
Suppression of Heavy Drinking and Alcohol Seeking by a Selective ALDH‐2 Inhibitor (2009)

Our findings suggest that selective reversible ALDH-2 inhibitors may have therapeutic potential to reduce excessive drinking and to suppress relapse in abstinent alcoholics.
Alternative Coordination Modes in Palladium(II)‐Diimino‐Bispyridine Complexes with an Axially Chiral Biphenyl Backbone (2005)

Abstract The chiral biphenyl‐bridged diimino‐bispyridine ligands N , N ′‐(6,6′‐dimethylbiphenyl‐2,2′‐diyl)bis(2‐pyridylmethyl)‐diimine( 1 )and N , N ′‐(6,6′‐dimethylbiphenyl‐2,2′‐diyl)bis[(6‐methyl‐2‐pyridyl)methyl]diimine ( 2 ) react with Pd(COD)Cl 2 to give, depending on the reaction conditions, either mono‐ or binuclear PdCl 2 complexes. In the binuclear complex 1 ‐(PdCl 2 ) 2 , the Pd nuclei are held at a distance of 3.37 Å by the ligand backbone. N , N ′‐(6,6′‐dimethylbiphenyl‐2,2′‐diyl)bis[(5‐methyl‐2‐furyl)methyl]diimine ( 3 ), with furyl instead of pyridyl rings, gives mononuclear, C 2 ‐ symmetric complexes only. Reactions of [Pd(NCCH 3 ) 4 ] 2+ (BF 4 – ) 2 with ligand 1 or 3 give the C 2 ‐ symmetric cations [ 1 ‐Pd] 2+ or [ 3 ‐Pd(NCCH 3 ) 2 ] 2+ , respectively, as their BF 4 – salts. Solid‐state structures of the chloride complexes 1 ‐PdCl 2 , 1 ‐(PdCl 2 ) 2 and 3 ‐PdCl 2 , and of the complex cations [ 1 ‐Pd] 2+ and [ 3 ‐Pd(NCCCH 3 ) 2 ] 2+ with tetradentate and bidentate ligand coordination, respectively, all show square‐planar coordination, with some distortion toward tedrahedral geometry due to the twisted biaryl‐backbone. Preliminary observations on norbornene polymerization with the catalysts 1 ‐PdCl 2 /MAO, 2 ‐PdCl 2 /MAO and [( 3 ‐Pd(NCCH 3 ) 2 ] 2+ suggest that a certain degree of stereoregularity of the polymers is induced by these chiral catalysts. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2005)
QoS and power consumption analysis of cooperative multicast scheme with cell zooming (2012)

As the demand for high-quality multimedia service over wireless networks has increased wireless multicast communication has been researched for many years in efforts to achieve high throughput. Recently, cooperative multicast scheduling scheme was proposed with the goal of achieving high throughput with good fairness. However, although much attention has been directed towards energy efficient communication, energy efficient cooperative multicast design has not received much consideration. Part of the reason for this is that significant relay power consumption is required for user cooperation. In this paper, we model Quality of Service (QoS) of multicast in terms of outage probability when the cooperative multicast scheme is adopted. From the model, we obtain analytical results for QoS and power consumption under a varying number of users and cell coverage of the Base Station (BS). Finally, the analytical models can be used to find the optimal B S's transmission power by predicting system performance if system configurations are given. This can help system deployment and system optimization.
ONE‐ AND TWO‐SESSION LASER TRABECULOPLASTY. A RANDOMIZED, PROSPECTIVE STUDY (1984)

Seventy-seven eyes with primary open angle glaucoma and exfoliation glaucoma were subjected to laser trabeculoplasty and followed in a prospective way. The full 360 degrees circumference was treated, but the patients were randomized in two groups: In group 1 the full treatment was given in one session, and in group 2 it was divided into two sessions one month apart. During the follow-up time of 3 to 18 (mean: 12) months both methods of treatment gave the same reduction of IOP. The only three cases with high post-operative transient pressure spike-occurred in group 1. Although this difference of course not is statistically significant it is in agreement with other studies suggesting that a two-session approach might be safer than treating the full circumference in one session. One month after the laser treatment the eyes of group 1, where the full circumference of the trabecular meshwork had been treated, showed only a slightly larger pressure reduction (not statistically significant) than the eyes of group 2 one month after treating 180 degrees of the meshwork.
Distribution of Deoxyribonucleic Acid Complementary to the Ribonucleic Acid of Avian Myeloblastosis Virus in Tissues of Normal and Tumor-Bearing Chickens (1972)

(3)H-labeled 70S ribonucleic acid (RNA) from purified avian myeloblastosis virus (AMV) was used as a probe in deoxyribonucleic acid (DNA)-RNA hybridization experiments to detect the presence of DNA complementary to the AMV genome in various tissues from noninfected normal chickens and from chickens infected with AMV. There was a remarkable constancy in the average cellular concentration of virus-specific DNA found in every tissue from the same uninfected chicken, and even in different chickens from the same strain. In contrast, different tissues from chickens bearing AMV-induced kidney tumors (embryonal nephromas) revealed an unequal distribution in the average virus-specific DNA content per cell. The increase was limited to tumor cells and to tissues that contain target cells for AMV, i.e., red blood cells, kidney cells, and possibly leukocytes. The red blood cells from AMV-infected chickens suffering from acute myeloblastic leukemia, although producing no virus, contained as many viral genome equivalents per cell as did leukemic myeloblasts known to produce large quantities of AMV. An increased viral DNA content was observed in the target cells of chickens that did not show any sign of tumor formation 6 months after infection with AMV. This study demonstrates that vertically transmitted viral DNA is uniformly and stably distributed among all tissues of the offspring, but that horizontal infection after hatching results in an increase in viral DNA content only in some dividing, target tissues that may or may not give rise to neoplasias.
Pangenome Analysis of Enterobacteria Reveals Richness of Secondary Metabolite Gene Clusters and their Associated Gene Sets (2019)

Abstract The growing number of sequenced genomes enables the study of secondary metabolite biosynthetic gene clusters (BGC) in phyla beyond well-studied soil bacteria. We mined 2627 enterobacterial genomes to detect 8604 BGCs, including nonribosomal peptide synthetases, siderophores, polyketide-nonribosomal peptide hybrids, and 60 other BGC types, with an average of around 3.3 BGCs per genome. These BGCs represented 212 distinct BGC families, of which only 20 have associated products in the MIBiG standard database with functions such as siderophores, antibiotics, and genotoxins. Pangenome analysis identified genes associated with a specific BGC encoding for colon cancer-related colibactin. In one example, we associated genes involved in the type VI secretion system with the presence of a colibactin BGC in Escherichia . This richness of BGCs in enterobacteria opens up the possibility to discover novel secondary metabolites, their physiological roles and provides a guide to identify and understand PKS associated gene sets.
In-line metrology for junction measurement and yield control (2002)

Modeling and device results demonstrate the high sensitivity of advanced transistors to small variation in junction depth. Non-destructive measurements with the Carrier Illumination/sup TM/ method correlate to NMOS drive current, RTA process variation, and small implant energy changes, demonstrating feasibility of in-line control for annealed implants.
The Reproduction of Specular Highlights on High Dynamic Range Displays (2006)

Recent advances in the design of high dynamic range (HDR) monitors enable the display of images having a large dynamic range, close to that encountered in the real world. As their usage will increase, we will be confronted with the problem of re-rendering images that have been mapped to standard dynamic range (SDR) displays so that they look natural on HDR monitors. We address this issue for SDR images representing original HDR scenes. We propose a tone scale function that takes advantage of the increase in dynamic range of HDR monitors to recreate the brightness of specular highlights, which were clipped or compressed by the capturing and rendering process to SDR. We validate the use of such functions with a psychovisual experiment conducted on an HDR display, where the observers' task was to judge pairs of tone-scaled images. The result of the experiment shows that using part of the extension of dynamic range provided by HDR displays to enhance the brightness of specular highlights leads to more natural looking images.
Supplementary Figure 1 from Increased Levels of Tetra-antennary <i>N</i>-Linked Glycan but Not Core Fucosylation Are Associated with Hepatocellular Carcinoma Tissue (2023)

&lt;p&gt;PDF file, 354KB, N-linked glycosylation of total protein from 16 HCC tissue and adjacent liver tissue pairs.&lt;/p&gt;
CMOS Compatible Integrated Optical Isolator (2007)

Herein we present our efforts to realise a novel integrated optical isolator. Utilising the principles of total internal reflection, the isolator is CMOS compatible and can be realised in a variety of materials.
A new discriminant analysis based on boundary/non-boundary pattern separation (2009)

In this paper, we propose a new discriminant analysis, named as linear boundary discriminant analysis (LBDA), which increases the class separability by differently emphasizing the boundary and non-boundary patterns. This is achieved by defining two novel scatter matrices and solving eigenproblem on the criterion described by these scatter matrices. As a result, the classification performance using the extracted features can be improved. This effectiveness of LBDA is theoretically explained by reformulating scatter matrices in pairwise form. In addition, LBDA can extract larger number of features than original LDA. The experiments are conducted to show the performance of LBDA, and the result shows that LBDA can outperform other algorithms in most cases.
O4‐06‐02: Active immunomodulation targeting abnormal conformation for the treatment of multiple neurodegenerative diseases (2012)

Alzheimer's Disease (AD) is the most common of the conformational neurodegenerative disorders (NDD), while prion diseases are the most transmissible NDD. No highly effective treatment is currently available for any NDD. Previously, we have shown that mutated Aβ peptides soluble and devoid of T-cell epitopes, produced a response which correlates with amelioration of AD pathology in animal models. Our lab has demonstrated that active immunization with antigens mimicking abnormal conformations, such as polymerized ABri (pABri), could elicit antibody responses to oligomerized Aβ and conformational aberrant hyperphosphorylated tau (ptau). We have now tested a combined vaccination using pBri and polymerized mutated Aβ (pAβ) in 3xTg mice and human PrP-Tg animals. We produced pBri and pAβ1-30K18K19, which by electron microscopy formed oligomer-like structures. The pBri alone was used as an immunogen in HuPrPTg animals and in conjunction with pAβ1-30KK in AD 3xTg mice, using alum as an adjuvant. At the age of 15-16 months the AD mice were subjected to behavioral testing followed by histological and biochemical analysis. The HuPrPTg were assessed for the presence of antibodies against PrPRes. 3xTg mice immunized animals showed no difference in locomotor activity compared to controls but a significant behavioral rescue by radial arm maze testing. The animals produced significant titers of IgM and IgG against Aβ42 oligomers. Histological analysis showed a significant reduction of both amyloid and tau pathology. Biochemically, Ab42 and soluble ptau were significantly reduced. In HuPrPTg animals a systemic IgM and IgG response against PrPRes was observed, similar to the systemic response obtained in our prior successful mucosal PrP vaccinations. pBri conformational vaccination can be used to elicit antibodies that recognize multiple pathological proteins, including PrPRes, oligomer Ab and ptau. In 3x Tg mice with both Ab and tau pathology which were vaccinated with the combined pABri+pAβ1-30KK, each of these pathologies were reduced histologically and biochemically, in association with a behavioral rescue. Such a combined approach targeting both pathological Aβ and tau is more likely to be efficacious in AD patients.