gebhart/patrepeval huggingface dataset:
Activation of a metal axial ligand bond in aluminum porphyrin by visible light (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTActivation of a metal axial ligand bond in aluminum porphyrin by visible lightYasuhiro. Hirai, Hideki. Murayama, Takuzo. Aida, and Shohei. InoueCite this: J. Am. Chem. Soc. 1988, 110, 22, 7387–7390Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/ja00230a019https://doi.org/10.1021/ja00230a019research-articleACS PublicationsRequest reuse permissionsArticle Views410Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hybrid electrolytes for group 2 cation-based electrochemical energy storage device (2023)

This invention relates to the field of energy storage devices, and especially electrochemical energy storage devices including electrolytes comprising an ionic liquid, one or more solvents, and one or more salts of a Group 2 element. Effects on electrochemical performance of the electrolyte of each of the components of the electrolyte were systematically determined. In addition, interactions between the electrolytes and separator films were dissected to optimize electrochemical performance of coin cell batteries.
Safe Operation of Automated Vehicles in Intersections (2018)

This report describes the technology needed for safe and efficient operation of signalized intersections in the presence of automated vehicles (AVs).
DECADES: A 67mm2, 1.46TOPS, 55 Giga Cache-Coherent 64-bit RISC-V Instructions per second, Heterogeneous Manycore SoC with 109 Tiles including Accelerators, Intelligent Storage, and eFPGA in 12nm FinFET (2023)

As Moore’s Law is coming to an end, heterogeneous SoCs have become ubiquitous, improving performance and efficiency with specialized hardware. However, the addition of hardware accelerators makes data supply more challenging. Feeding data to accelerators becomes a bottleneck, especially for data-intensive workloads such as graph analytics, sparse linear algebra, and machine learning applications. DECADES addresses this issue with a combination of accelerators, embedded FPGA (eFPGA), and its unique ‘‘intelligent storage’’ (IS) tile. DECADES is one of the largest chips ever built in academia and has the highest core count of cache-coherent, OS-capable, 64-bit RISC-V processors.
Organophosphorus Chemistry (2006)

Organophosphorus Chemistry provides a comprehensive annual review of the literature. Coverage includes phosphines and their chalcogenides, phosphonium salts, low coordination number phosphorus compounds, penta- and hexa-coordinated compounds, tervalent phosphorus acids, nucleotides and nucleic acids, ylides and related compounds, and phosphazenes. The series will be of value to research workers in universities, government and industrial research organisations, whose work involves the use of organophosphorus compounds. It provides a concise but comprehensive survey of a vast field of study with a wide variety of applications, enabling the reader to rapidly keep abreast of the latest developments in their specialist areas. Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.
DC dynamic pull-in predictions for a generalized clamped–clamped micro-beam based on a continuous model and bifurcation analysis (2008)

This study is devoted to providing precise predictions of the dc dynamic pull-in voltages of a clamped–clamped micro-beam based on a continuous model. A pull-in phenomenon occurs when the electrostatic force on the micro-beam exceeds the elastic restoring force exerted by beam deformation, leading to contact between the actuated beam and bottom electrode. DC dynamic pull-in means that an instantaneous application of the voltage (a step function such as voltage) is applied. To derive the pull-in voltage, a dynamic model in partial differential equations is established based on the equilibrium among beam flexibility, inertia, residual stress, squeeze film, distributed electrostatic forces and its electrical field fringing effects. The method of Galerkin decomposition is then employed to convert the established system equations into reduced discrete modal equations. Considering lower-order modes and approximating the beam deflection by a different order series, bifurcation based on phase portraits is conducted to derive static and dynamic pull-in voltages. It is found that the static pull-in phenomenon follows dynamic instabilities, and the dc dynamic pull-in voltage is around 91–92% of the static counterpart. However, the derived dynamic pull-in voltage is found to be dependent on the varied beam parameters, different from a fixed predicted value derived in past works, where only lumped models are assumed. Furthermore, accurate closed-form predictions are provided for non-narrow beams. The predictions are finally validated by finite element analysis and available experimental data.
Preprocessor design for hybrid preprocessing with selection in massive MISO systems (2017)

Hybrid preprocessing, where an analogue preprocessing matrix is used to feed a large antenna array to fewer up/down-conversion chains, helps reduce hardware cost of massive Multiple-Input-Multiple-Output systems. Here, we analyze a variant of hybrid preprocessing, namely hybrid preprocessing with selection (HPwS), as an attractive solution to reduce this hardware cost while retaining good performance. In HPwS, the preprocessing matrix, built from radio frequency (RF) hardware, has a larger number of input ports L than the number of up/down-conversion chains K. A bank of RF switches connects the instantaneously best K input ports to the up/down-conversion chains. The preprocessor is designed based on average channel statistics and therefore needs to be updated only infrequently. This allows for a higher diversity-order and/or simpler RF hardware than some conventional hybrid preprocessing systems. In this paper, we propose a generic architecture of HPwS with a possibly non-unitary rectangular preprocessing matrix. A novel preprocessor is designed that maximizes a capacity lower bound for channels with isotropic scattering. In addition, we study how L, the number of users, and the use of low complexity RF hardware, such as discrete phase-shifters, impact system performance. We also present a method to extend the preprocessor design to anisotropic channels.
Abstract 2515: Anti- GP88 (progranulin) antibody to GP88 (progranulin) inhibits breast tumor growth and restores sensitivity to tamoxifen (2012)

Abstract GP88 (Progranulin, PCDGF, acrogranin) is an 88 kDa glycoprotein that is the largest member of the granulin/epithelin family of growth modulators characterized by 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Our laboratory demonstrated the role of GP88 as an autocrine growth and survival factor in breast cancer: 1) GP88 expression increases with tumorigenesis; 2) inhibition of GP88 expression by antisense transfection in MDA-MB-468 cells inhibited tumor formation in nude mice by 90%; 3) in ER+ breast cancer cells, GP88 stimulates proliferation and its overexpression confers estrogen independence; 4) GP88 is a strong survival factor that confers resistance to anti-estrogen and aromatase inhibitors in ER+ breast cancer; 5) GP88 is expressed in 80% invasive ductal carcinoma and 60% of ductal carcinoma whereas it is negative in benign lesions and normal mammary epithelial cells; 6) pathological studies with 530 cases of ER+ invasive ductal carcinoma showed that GP88 tumor expression is a prognostic indicator of recurrence in early stage breast cancer patients; 7) GP88 is secreted and can be detected in the serum of breast cancer patients at an increased level when compared to healthy subjects. Based on these results GP88 represents an ideal therapeutic and diagnostic target in breast cancer. We developed a neutralizing anti-GP88 antibody AG1. AG1 inhibits GP88 biological effect in a dose-dependent fashion. In the present study, we investigated the effect of AG1 on the tumor development of tamoxifen sensitive (MCF-7) and resistant (TamR) estrogen receptor positive breast cancer cells lines injected in nude mice. We show that AG1 alone (5mg/kg) inhibited tumor growth of MCF-7 cells injected into nude mice in a similar efficacy as tamoxifen. Interestingly, AG1 in combination with tamoxifen inhibited by more than 50% tumor formation of TamR cells, whereas tamoxifen only had no effect. These data suggest that inhibiting GP88 provide a novel and alternate pathway for restoration of tamoxifen sensitivity in ER+ breast cancer. This works is supported by grant 2R44CA124179 from the National Cancer Institute. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2515. doi:1538-7445.AM2012-2515
Preconditioning for Large Scale-Free Graphs. (2013)

Abstract not provided.
Using electro-optic sampling in two-dimensional mapping of the distribution of electric field over a resonant electrode (2003)

In this study, we present some results of a rigorous experimental investigation of the distributions of electric field for two variants of the double-slab structure. Electro-optic (EO) sampling was used to measure the distribution of electric field over the electrode.
Conductive-Noise Suppression Control Improved by Synchronous Compensation for Switching (2021)

In noise suppression control that switches between two inverters with opposite phases, the synchronization accuracy of switching limits the noise reduction and bandwidth. To improve the noise suppression control, this paper proposes a control method that detects the rise and fall of the inverter output voltage and compensates for the synchronization error between two inverters. The effectiveness of the proposed method was verified by applying it to the double-three-phase motor drive system; the synchronization error was reduced to 10ns.
Photoluminescence and Raman scattering in axial Si/Ge nanowire heterojunctions (2009)

In crystalline, dislocation-free, Si/Ge nanowire axial heterojunctions grown using the vapor-liquid-solid technique, photoluminescence and Raman spectroscopy reveal a SiGe alloy transition layer with preferential chemical composition and strain. In addition to the lattice mismatch, strain in Si/Ge nanowires is observed from a temperature dependent study to be affected by the difference in Si and Ge thermal expansion. The conclusions are supported by analytical transmission electron microscopy measurements.
Tourniquet Use During Cementation Only During Total Knee Arthroplasty: A Randomized Trial (2013)

With the numbers available, our results suggest that there are no important clinical differences between patients who had a tourniquet inflated throughout the procedure compared with those who had it inflated only during cementation. Tourniquet inflation for cementation only provides the benefit of bloodless bone for fixation and may eliminate the risks associated with prolonged tourniquet use.
Numerical and experimental investigation of impacts of nonlinear scattering encapsulated microbubbles on Nakagami distribution (2019)

The Nakagami distribution was suitable for the EMBs characterization but the corresponding m parameter was affected by the EMBs' nonlinearity. These validations provided support and nonlinear impact assessment for the EMBs' characterization using the Nakagami statistical model in the future.
ChemInform Abstract: Cr‐MCM‐41‐Catalyzed Selective Oxidation of Alkylarenes with TBHP. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hierarchical Bayesian Models of Verb Learning in Children (2012)

The productivity of language lies in the ability to generalize linguistic knowledge to new situations. To understand how children can learn to use language in novel, productive ways, we must investigate how children can find the right abstractions over their input, and how these abstractions can actually guide generalization. In this thesis, I present a series of hierarchical Bayesian models that provide an explicit computational account of how children can acquire and generalize highly abstract knowledge of the verb lexicon from the language around them. By applying the models to large, naturalistic corpora of child-directed speech, I show that these models capture key behaviours in child language development. These models offer the power to investigate developmental phenomena with a degree of breadth and realism unavailable in existing computational accounts of verb learning. By most accounts, children rely on strong regularities between form and meaning to help them acquire abstract verb knowledge. Using a token-level clustering model, I show that by attending to simple syntactic features of potential verb arguments in the input, children can acquire abstract representations of verb argument structure that can reasonably distinguish the senses of a highly polysemous verb. I develop a novel hierarchical model that acquires probabilistic representations of verb argument structure, while also acquiring classes of verbs with similar overall patterns of usage. In a simulation of verb learning within a broad, naturalistic context, I show how this abstract, probabilistic knowledge of alternations can be generalized to new verbs to support learning. I augment this verb class model to acquire associations between form and meaning in verb argument structure, and to generalize this knowledge appropriately via the syntactic and semantic aspects of verb alternations. The model captures children&apos;s ability to use the alternation pattern of a novel verb to infer aspects of the verb&apos;s meaning, and to use the meaning of a novel verb to predict the range of syntactic forms in which the verb may participate. These simulations also provide new predictions of children&apos;s linguistic development, emphasizing the value of this model as a useful framework to investigate verb learning in a complex linguistic environment.
Abstract 4695: Functional group elaboration of a low molecular weight fragment to yield the novel BET family bromodomain inhibitor ABBV-075 (2016)

Abstract Phenotypic cell-based screening assays combined with affinity chromatography and mass-spectrometry identified the BET family of bromodomains as potential targets for blocking proliferation in a variety of cancer cell lines. Lead-finding investigations included screening a library of compounds with an average molecular weight of 225 for binding to the 13C-labeled 2nd bromodomain of BRD4 using 2-dimensional NMR. A pyridazinone fragment emerged from this effort that possessed weak binding affinity (Kd = 130 uM). The binding affinity was improved by roughly 100,000-fold through an X-ray structure enabled medicinal chemistry program that included moving to a pyrrolopyridone core along with judicious placement of additional functional groups. Antiproliferative potencies strongly correlated with potencies in a cell-based target engagement assay, suggesting that the antiproliferative effects resulted from the inhibition of BRD4/BET protein function. In vitro metabolite ID studies in rat liver microsomes helped identify sites of oxidative metabolism. The addition of fluorine atoms at these locations improved rat in vitro microsomal stability that translated to low in vivo clearance and high oral exposure in rat. The final molecule, ABBV-075, exhibited long half-lives and low unbound clearances in rat, mouse, dog and monkey. ABBV-075 demonstrated significant tumor growth inhibition in mouse flank xenograft studies representing diverse hematological and solid tumor malignancies and recently entered Phase I clinical studies. Disclosures: All authors are employees of AbbVie. The design, study conduct, and financial support for this research were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the publication. Citation Format: Keith McDaniel, Le Wang, George Sheppard, Steve Fidanze, John Pratt, Dachun Liu, Lisa Hasvold, Robert Mantei, Chang Park, Aparna Sarthy, Leiming Li, Daniel H. Albert, Xiaoyu Lin, Scott Warder, Emily Faivre, Mai H. Bui, Xiaoli Huang, Denise Wilcox, Rongqi Wang, Terry Magoc, Ganesh Rajaraman, Andrew Petros, Sanjay Panchal, Chaohong Sun, Guowei Fang, Steven W. Elmore, Saul Rosenberg, Yu Shen, Warren Kati. Functional group elaboration of a low molecular weight fragment to yield the novel BET family bromodomain inhibitor ABBV-075. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4695.
Nanoelectromechanical DRAM for ultra-large-scale integration (ULSI) (2006)

A nanoelectromechanical (NEM) device developed for dynamic random access memory (DRAM) is reported. A vertical nanotube structure is employed to form the electromechanical switch and capacitor structure. The mechanical movement of the nanotube defines 'ON' and 'OFF' states and the electrical signals which result lead to charge storage in a vertical capacitor structure as in a traditional DRAM. The vertical structure contributes greatly to a decrease in cell dimension. The main concept of the NEM switch and capacitor can be applied to other memory devices as well
Diagnosis and Treatment of Optic Nerve Trauma (2014)

Decreasing visual acuity secondary to orbital trauma or orbital and anterior skull base surgery may be caused by either sudden space-occupying intraorbital lesions, including retrobulbar hemorrhage (RBH), or direct damage to the prechiasmatic pathway. Contrary to traumatic optic neuropathy, RBH must be diagnosed and treated immediately to prevent permanent damage to the visual system. Therefore, monitoring and handling of visual pathway damage are mandatory. Flash visual evoked potentials and electroretinograms can provide evidence of the status of conductivity of the visual pathway when clinical assessment is not feasible. Both are thus essential diagnostic procedures not only for primary diagnosis but also for intraoperative evaluation. In case of RBH surgical decompression is compulsory. However, traumatic optic neuropathy does not respond to either corticosteroids or optic canal surgery. Modern craniomaxillofacial surgery requires detailed consideration of the diagnosis and treatment of traumatic visual pathway damage with the ultimate goal of preserving visual acuity.
A Cyano‐Bridged Vanadium–Niobium Bimetal Assembly Exhibiting a High Curie Temperature of 210 K (Eur. J. Inorg. Chem. 16/2012) (2012)

Abstract The front cover picture shows a schematic representation of the coordination network and the temperature dependence of magnetization of a cyano‐bridged V–Nb bimetal assembly, K 0.59 V II 1.59 V III 0.41 [Nb IV (CN) 8 ] · (SO 4 ) 0.50 · 6.9H 2 O. This compound exhibits ferrimagnetism with a high Curie temperature ( T C ) of 210�K. This temperature is the highest T C value among those of octacyano‐bridged bimetal assemblies. The Short Communication by S. Ohkoshi et al. on p. 2649 ff. demonstrates that the increase in the superexchange pathways of V II –NC–Nb IV contributes to the achievement of the high T C value. magnified image
Ribosides and Ribotide of a Fairy Chemical, Imidazole-4-carboxamide, as Its Metabolites in Rice (2019)

The metabolism of imidazole-4-carboxamide (ICA) in plants has been unknown. Two metabolites (<b>1</b> and <b>2</b>) were isolated from ICA-treated rice, and their structures were determined by spectroscopic analysis including the single-crystal X-ray diffraction technique and synthesis. The ribotide of ICA (<b>3</b>), whose existence was predicted, was also synthesized and detected from the treated rice by LC-MS/MS. These results indicated that rice might interconvert ICA, <b>1</b>, and <b>3</b> to regulate the biological activity.
ChemInform Abstract: Polyfluorinated Cycloalkoxyphenyl Ether Systems (III) as Dopants for Liquid Crystal Display Applications (2011)

Abstract synthesis and electro‐optical properties
Role of basal lamina in neoplastic disorganization of tissue architecture. (1981)

We have studied a transplantable carcinoma of the rat pancreas [Reddy, J. K. & Rao, M. S. (1977( Science 198, 78-80] that is composed of cytologically differentiated acinar cells that have lost their epithelial orientation and do not form acini. Light microscopy shows, however, consistent palisading, reorientation, and polarization of these cells in areas of contact with the vasculature. Electron microscopy reveals a normal basal lamina (BL) along the basal portions of repolarized tumor cells that is physically separate from the endothelial BL. We used indirect immunofluorescence to examine the distribution of BL constituents, laminin (Lm) and type IV collagen (type IV), within the different microenvironments of this tumor. In normal pancreas, Lm and type IV are distributed linearly, outlining acini and blood vessels. In the tumor parenchyma, type IV is not detected, whereas Lm appears in a punctate distribution outlining cells. Reorientation of tumor cells is observed only along linearly deposited Lm and type IV bordering vessels. These data indicate that this nonmetastatic tumor has lost the ability to produce or maintain a complete BL within its disorganized parenchyma, while its cells retain the capacity to produce and reorganize along liner BL when in contact with vascular adventitia. We suggest that failure to maintain a complete BL may be involved in the neoplastic disorganization of normal tissue architecture as well as in the breakdown of boundaries during the development of invasive carcinomata.