gebhart/patrepeval huggingface dataset:
Maximizing visibility in collaborative trajectory planning (2014)

In this paper we address the issue of coordinating the trajectories of two collaborating robots in environments with obstacles so that visibility between them is maximized in the presence of competing constraints. Specifically, we examine the problem of allowing one robot (the “photographer”) to follow another robot (“the subject”) through a planar environment while maintaining visual contact to the maximum degree consistent with an efficient traversal. This problem has numerous applications, for instance in scenarios where communication between robots requires line-of-sight. We formalize this problem in the context of centralized kinodynamic planning and we present solutions based on the asymptotically optimal sampling-based RRT* planner. We discuss connections to the traditional formulation of pursuit-evasion games where the analysis typically ends the moment the evader manages to escape the pursuer's visibility region. We also illustrate types of environments and other conditions under which allowing the pair of robots to break the line-of-sight is a better option than always requiring the presence of visual contact.
Coordination Frameworks for Web Services (2004)

This chapter contains sections titled: WSCL: Web Services Conversation Language WSCI: Web Service Choreography Interface WS-coordination: Specifying Coordination Web Service Transaction Types BTP: Business Transaction Protocol Notes Exercises
Abstract 1413: Replication obstacles formed within common fragile sites under replication stress are targeted by the global genomic nucleotide excision repair pathway (2017)

Abstract CFS’s are genomic loci present in higher vertebrates that are particularly sensitive to various forms of replication stress and suffer from increased breakage and rearrangements in tumors. They have rather enigmatic evolutionary role and employ various DNA repair and checkpoint mechanisms promoting their stability. We used an original approach for identification of CFS’s associated factors based on DNA probe designed to match the high flexibility island sequences typically present in some of the highly expressed CFS’s. This probe was used as affinity bait for fishing specifically enriched proteins which were further identified using SILAC and quantitative mass spectrometry. Among already known CFS’s stabilizers we identified also hits so far not implicated in CFS’s maintenance. Interestingly, most of these novel hits are components of the global genomic nucleotide excision repair pathway (GG-NER). Knock down-based functional experiments revealed that GG-NER works most likely as an important trigger turning the CFS’s-associated replication obstacles into DNA lesion further recognized by the ATR-promoted cellular checkpoint which function is to block an escape of DNA replication intermediates into mitosis and the next cell generation. Work was supported by the Grant Agency of the Czech Republic 13-17555S, Czech-BioImaging project (LM2015062 funded by MEYS, CR) and Ministry of Education of the Czech Republic (LO1304). Citation Format: Martin Mistrik, Lucie Beresova, Eva Vesela, Ivo Chamrad, Jiri Voller, Masayuki Yamada, Tomas Furst, Rene Lenobel, Katarina Chroma, Jan Gursky, Jiri Bartek. Replication obstacles formed within common fragile sites under replication stress are targeted by the global genomic nucleotide excision repair pathway [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1413. doi:10.1158/1538-7445.AM2017-1413
An ultrasonic technology for production of antibacterial nanomaterials and their coating on textiles (2014)

A method for the production of antibacterial ZnO nanoparticles has been developed. The technique combines passing an electric current with simultaneous application of ultrasonic waves. By using high-power ultrasound a cavitation zone is created between two zinc electrodes. This leads to the possibility to create a spatial electrical discharge in water. Creation of such discharge leads to the depletion of the electrodes and the formation of ZnO nanoparticles, which demonstrate antibacterial properties. At the end of this reaction the suspension of ZnO nanoparticles is transported to a specially developed ultrasonic reactor, in which the nanoparticles are deposited on the textile. The nanoparticles are embedded into the fibres by the cavitation jets, which are formed by asymmetrically collapsing bubbles in the presence of a solid surface and are directed towards the surface of textile at very high velocities. Fabrics coated with ZnO nanoparticles by using the developed method showed good antibacterial activity against E. coli.
The Limits of Human Stereopsis in Space and Time (2014)

To encode binocular disparity, the visual system determines the image patches in one eye that yield the highest correlation with patches in the other eye. The computation of interocular correlation occurs after spatiotemporal filtering of monocular signals, which leads to restrictions on disparity variations that can support depth perception. We quantified those restrictions by measuring humans' ability to see disparity variation at a wide range of spatial and temporal frequencies. Lower-disparity thresholds cut off at very low spatiotemporal frequencies, which is consistent with the behavior of V1 neurons. Those thresholds are space-time separable, suggesting that the underlying neural mechanisms are separable. We also found that upper-disparity limits were characterized by a spatiotemporal, disparity-gradient limit; to be visible, disparity variation cannot exceed a fixed amount for a given interval in space-time. Our results illustrate that the disparity variations that humans can see are very restricted compared with the corresponding luminance variations. The results also provide insight into the neural mechanisms underlying depth from disparity, such as why stimuli with long interocular delays can still yield clear depth percepts.
GraDED: A graph-based parametric dictionary learning algorithm for event detection (2017)

Short-time event detection from videos obtained using handheld or car-mounted cameras is an overarching challenge in surveillance. The problem demands simultaneous spatiotemporal localization of the event along with removal of a dynamic background. Existing state-of-the-art techniques are sensitive to non-uniform jitter, changing background, and clutter. In this paper, we propose graph Laplacian assisted parametric dictionary learning, GraDED to account for the aforementioned variations. The temporal occurrence and duration of the event is determined from weights learned using a dynamic graph, while the spatial localization is performed by graph based dictionary learning. We demonstrate the efficacy of our approach by comparing with three state-of-the-art methods and achieve on average an overall increase of 0.08 in specificity and 0.6 in sensitivity for event detection.
Is radiation necrosis in radiated melanoma brain metastasis increasing because immunotherapy is contributing to this or are patients just living longer? (2021)

e21518 Background: The use of immune checkpoint inhibitors, particularly combination ipilimumab and nivolumab, has drastically changed the management of patients with melanoma brain metastasis. Select patients also benefit from brain-directed stereotactic radiation. Radiation necrosis is a risk associated with stereotactic radiation that oncologists have been observing more frequently in the era of immunotherapy. Methods: Patients were identified who had a history of metastatic melanoma treated with stereotactic brain radiation who subsequently developed radiation necrosis. Brain tissue from those patients with a subsequent resection of their radiation necrosis was obtained and examined for immune infiltrate and other factors. The tissue obtained was evaluated by blinded pathologists who graded % viable tissue, % necrosis, % tumor and % fibrosis. In addition, they graded inflammation on a scale of 1-3. Results: Seven patients were identified who had surgery for radiation necrosis following radiation to melanoma brain metastasis. Tissue was available for five patients. Two patients had received no prior immunotherapy, one patient had received ipilimumab and two patients received combination ipilimumab and nivolumab. The samples obtained consisted of almost entirely viable brain tissue or necrosis. There was minimal inflammation seen in all patients’ samples including those who had not received immunotherapy and those who had. Conclusions: Radiation necrosis in patients on immunotherapy who receive brain-directed stereotactic radiation is a rising problem. On pathologic evaluation increased immune infiltrate is not observed in patients on immunotherapy with radiation necrosis compared to those who never received immunotherapy. This suggests that the increased rates of radiation necrosis may be more likely associated with longer survival as opposed to a direct causative effect from the immunotherapy although with our limited sample size this will need further exploration.[Table: see text]
Pediatric Back Pain: A Scoring System to Guide Use of Magnetic Resonance Imaging (2021)

Level III-diagnostic study.
<title>Influence of process variation on the functionality of a high-pressure sensor</title> (2002)

A sensor designer has to keep in mind a couple of things developing a new product. These are performance, reliability and last but not least cost. Cost is mainly a function of yield. To be successful on the market, it is therefore necessary to predict yield for a new design, based on its process steps. This can be done only by modeling a sensor based on process parameters as input to the models. How to realize this, will be shown for the design of a high pressure sensor.
A New Generation of Materials for the Calendering Industry (2000)

While polyvinyl chloride (PVC) has been employed in the calendering industry for many years, other polymers have not been as widely used. Ethylene styrene interpolymers (ESI) demonstrate the requisite rheological properties and thermal stability to be successfully used in the calendering process. Commercial scale validations were performed on ESI based formulations. Examples of the applicability of ESI to calendering are discussed.
Measurement Methods for High-Frequency Characterizations of Permeability, Permittivity, and Core Loss of Mn-Zn Ferrite Cores (2022)

Manganese–zinc (Mn-Zn) ferrites are the primary choice for high-frequency and high-power magnetic components. Optimum material selection is essential for high-performance magnetic component design. However, the manufacturers’ material specifications usually do not provide sufficient information to optimize the design. Complex permeability and permittivity, as well as specific power loss, are typically provided as one value, regardless of the core shape and size. Magnetic component design based on these incomplete specifications can result in a poorly optimized component. This article proposes methods to determine the properties of Mn-Zn ferrite at high frequencies, with tests up to 20 MHz. This article also presents experimental complex permeability and permittivity frequency characteristics for four ferrite materials: 3E10, 3F36, 3E65, and 3C95. The resulting fitted parameters for the equivalent-circuit model can be used in any design algorithm or simulation tool. The impacts of physical size, temperature and force on complex permeability and permittivity are also considered.
Development and optimization of a protocol for automated, low-throughput RNA purification from whole blood using the PAXgene blood RNA system (2007)

A44 Introduction: Gene expression analysis in peripheral blood is an important tool in molecular diagnostics, monitoring diseases at the molecular level, clinical research, and clinical trials of new drugs. Since the introduction of the PAXgene Blood RNA System, researchers have expressed a need for a low-throughput, automated (LTA) solution for RNA preparation from blood collected in PAXgene Blood RNA Tubes, with purification based on the proven silica-membrane spin-column technology in the PAXgene Blood RNA Kit. The aim of this research study was to develop and optimize a protocol for LTA RNA purification using PAXgene Blood RNA Tubes and the (manual) PAXgene Blood RNA Kit on a robotic platform.  (Note: The combination of the PAXgene Blood RNA Kit on the robotic platform is for research use only and not for use in diagnostic procedures. It has not received clearance or approval for clinical use in the US, Canada or Europe.)  Methods: Replicate blood samples were collected in PAXgene Blood RNA Tubes, and starting from the resuspended nucleic acid pellet, RNA was purified using either the manual procedure according to the PAXgene Blood RNA Kit handbook (reference protocol) or the new automated purification procedure (test protocol). To enable comparison of the test and reference protocol performance, purified RNA from both protocols was analyzed spectrophotometrically, by capillary gel electrophoresis, in real-time quantitative RT-PCR (RQ-RT-PCR), and in PCR assays to measure RNA yield, purity, integrity, RQ-RT-PCR inhibition, and traces of genomic DNA (gDNA).  Results: The new automated PAXgene Blood RNA protocol was highly reliable in that there were no failures in sample processing. Furthermore, the quantity and quality of purified RNA was comparable between both protocols: Greater than 95% of samples processed on the instrument yielded RNA of >3micrograms per tube, all samples contained Conclusion: This research study demonstrates that the new automated protocol using proven silica-membrane spin-column technology and existing chemistry with the new robotic platform provides an efficient and reliable alternative LTA solution to the manual protocol. Automated processing reduces user interaction and hands-on time, resulting in a more convenient workflow compared to the manual PAXgene Blood RNA procedure.
Notch signaling is necessary for epithelial growth arrest by TGF-β (2007)

Transforming growth factor β (TGF-β) and Notch act as tumor suppressors by inhibiting epithelial cell proliferation. TGF-β additionally promotes tumor invasiveness and metastasis, whereas Notch supports oncogenic growth. We demonstrate that TGF-β and ectopic Notch1 receptor cooperatively arrest epithelial growth, whereas endogenous Notch signaling was found to be required for TGF-β to elicit cytostasis. Transcriptomic analysis after blocking endogenous Notch signaling uncovered several genes, including Notch pathway components and cell cycle and apoptosis factors, whose regulation by TGF-β requires an active Notch pathway. A prominent gene coregulated by the two pathways is the cell cycle inhibitor p21. Both transcriptional induction of the Notch ligand Jagged1 by TGF-β and endogenous levels of the Notch effector CSL contribute to p21 induction and epithelial cytostasis. Cooperative inhibition of cell proliferation by TGF-β and Notch is lost in human mammary cells in which the p21 gene has been knocked out. We establish an intimate involvement of Notch signaling in the epithelial cytostatic response to TGF-β.
Lowering of the miscibility gap in the dioctanoylphosphatidylcholine-water system by addition of urea (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLowering of the miscibility gap in the dioctanoylphosphatidylcholine-water system by addition of ureaBruce L. Carvalho, Giuseppe Briganti, and Sow Hsin ChenCite this: J. Phys. Chem. 1989, 93, 10, 4282–4286Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://pubs.acs.org/doi/10.1021/j100347a073https://doi.org/10.1021/j100347a073research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Lipid Loss Increases Stratum Corneum Stress and Drying Rates (2020)

These results suggest that lipid loss causes marked increases in SC drying stresses, which may in turn contribute to changes in skin perception. NMF extraction may be important in vivo, but has remarkably little impact in isolated SC.
Improving Efficiency in Large-Scale Decentralized Distributed Training (2020)

Decentralized Parallel SGD (D-PSGD) and its asynchronous variant Asynchronous Parallel SGD (AD-PSGD) is a family of distributed learning algorithms that have been demonstrated to perform well for large-scale deep learning tasks. One drawback of (A)D-PSGD is that the spectral gap of the mixing matrix decreases when the number of learners in the system increases, which hampers convergence. In this paper, we investigate techniques to accelerate (A)D-PSGD based training by improving the spectral gap while minimizing the communication cost. We demonstrate the effectiveness of our proposed techniques by running experiments on the 2000-hour Switchboard speech recognition task and the ImageNet computer vision task. On an IBM P9 supercomputer, our system is able to train an LSTM acoustic model in 2.28 hours with 7.5% WER on the Hub5-2000 Switchboard (SWB) test set and 13.3% WER on the CallHome (CH) test set using 64 V100 GPUs and in 1.98 hours with 7.7% WER on SWB and 13.3% WER on CH using 128 V100 GPUs, the fastest training time reported to date.
Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligence (2022)

Abstract The protein STING (stimulator of interferon genes) is a central regulator of the innate immune system and plays an important role in antitumor immunity by inducing the production of cytokines such as type I interferon (IFN). Activation of STING stems from the selective recognition of endogenous cyclic dinucleotides (CDNs) by the large, polar, and flexible binding site, thus posing challenges to the design of small molecule agonists with drug-like physicochemical properties. In this work we present the design of SNX281, a small molecule STING agonist that functions through a unique self-dimerizing mechanism in the STING binding site, where the ligand dimer approximates the size and shape of a cyclic dinucleotide while maintaining drug-like small molecule properties. SNX281 exhibits systemic exposure, STING-mediated cytokine release, strong induction of type I IFN, potent in vivo antitumor activity, durable immune memory, and single-dose tumor elimination in mouse models via a C max -driven pharmacologic response. Bespoke computational methods – a combination of quantum mechanics, molecular dynamics, binding free energy simulations, and artificial intelligence – were developed during the course of the project to design SNX281 by explicitly accounting for the unique self-dimerization mechanism and the large-scale conformational change of the STING protein upon activation. Over the course of the project, we explored millions of virtual molecules while synthesizing and testing only 208 molecules in the lab. This work highlights the value of a multifaceted computationally-driven approach anchored by methods tailored to address target-specific problems encountered along the project progression from initial hit to the clinic.
A Review of Anesthetic Effects on Renal Function: Potential Organ Protection (2017)

The effects of anesthetic drugs on renal failure are particularly important in the context of kidney transplantation, since the conditions of preservation following removal profoundly influence the recovery of organ function. Currently, preservation procedures are typically based on the usage of a cold-storage solution. Some anesthetic drugs induce anti-inflammatory, anti-necrotic, and anti-apoptotic effects. A more thorough understanding of anesthetic effects on renal function can present a novel approach for developing organ-protective strategies. The aim of this review is to discuss the effects of different anesthetic drugs on renal function, with particular focus on IR injury. Many studies have demonstrated the organ-protective effects of some anesthetic drugs, specifically propofol, which indicate the potential of some anesthetics to introduce novel organ protective targets. This is not surprising, since lipid emulsions are major components of propofol, which accumulating data show provide organ protective effects against IR injury. Key Messages: Thorough understanding of the interaction between anesthetic drugs and renal function remains fundamental to the delivery of safe perioperative care and to optimizing outcomes after renal surgeries, particularly transplant procedures. Anesthetics can be repurposed for organ protection with more information about their effects, especially during transplant procedures. Here, we review the effects of different anesthetic drugs - specifically those that contain lipids in their structure, with special reference to IR injury.
268: Loss of Heterozygosity (LOH) of Single-Nucleotide Polymorphisms (SNPS) Detected in the Urine of Patients with Bladder Cancer: Correlation with Stage and Clinical Outcome (2004)

You have accessJournal of UrologyDiscussed Poster, Sunday, May 9, 2004, 8:00 am - 12:00 pm1 Apr 2004268: Loss of Heterozygosity (LOH) of Single-Nucleotide Polymorphisms (SNPS) Detected in the Urine of Patients with Bladder Cancer: Correlation with Stage and Clinical Outcome Ganesh S. Palapattu, Craig G. Rogers, Mohammed Hoque, Mark P. Schoenberg, and David Sidransky Ganesh S. PalapattuGanesh S. Palapattu More articles by this author , Craig G. RogersCraig G. Rogers More articles by this author , Mohammed HoqueMohammed Hoque More articles by this author , Mark P. SchoenbergMark P. Schoenberg More articles by this author , and David SidranskyDavid Sidransky More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)37530-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "268: Loss of Heterozygosity (LOH) of Single-Nucleotide Polymorphisms (SNPS) Detected in the Urine of Patients with Bladder Cancer: Correlation with Stage and Clinical Outcome." The Journal of Urology, 171(4S), pp. 70–71 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 70-71 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Ganesh S. Palapattu More articles by this author Craig G. Rogers More articles by this author Mohammed Hoque More articles by this author Mark P. Schoenberg More articles by this author David Sidransky More articles by this author Expand All Advertisement PDF downloadLoading ...
Author response: An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups (2018)

A series of novel compounds selective for N-methyl-D-aspartate-type glutamate receptor includes positive and negative allosteric modulators that act at the same site, show use-dependence, increase agonist potency, and have differential activity based on the agonist concentration.