gebhart/patrepeval huggingface dataset:
Quantification of illuminant metamerism for four coloration systems via metameric mismatch gamuts (1988)

Abstract Illuminant metamerism was evaluated by generating achromatic metamers for an acrylic‐enamel coating, an acrylobutadiene styrene polymer, a polyester textile, and a nylon textile using computer colorant formulation techniques. The tristimulus matching algorithm used to generate the metamers was based on Kubelka‐Munk turbid media theory. By definition, each set of metamers that were formulated to match under CIE illuminant D 65 for the 1964 CIE standard observer would mismatch under a test illuminant, forming a gamut of colorimetric coordinates. These metameric mismatch gamuts were evaluated quantitatively using multivariate statistics. Illuminants A, F2, and F11, representing incandescent, cool‐white fluorescent, and narrow‐band fluorescent, respectively, were used as test illuminants. Illuminant similarities, coloration system similarities, tristimulus variability, and reference illuminant selection criteria were evaluated.
Immunization with Treponema pallidum endoflagella alters the course of experimental rabbit syphilis (1990)

Rabbits were immunized over a 32-week period with a total of 450 micrograms of purified Treponema pallidum endoflagella. As measured by enzyme-linked immunosorbent assay, sera from immunized rabbits had antiendoflagellar antibody titers that were fivefold greater than titers of sera from infected immune rabbits and patients with secondary disease. Sera from all immunized animals possessed complement-dependent treponemicidal activity as measured by in vitro immobilization. Immunized animals challenged with virulent T. pallidum were not protected from symptomatic infection but showed an altered course of lesion development.
26-Gbps PON Transmission over 40-km using Duobinary Detection with a Low Cost 7-GHz APD-Based Receiver (2012)

26-Gbps serial transmission over 40-km is demonstrated for downstream PON. Duobinary detection allows for a 7-GHz APD receiver at the ONU. Transmission at this rate enables future 100G-EPON in a cost effective way using 4×25.8-Gbps TWDM.
An amperometric enzyme biosensor for real‐time measurements of cellobiohydrolase activity on insoluble cellulose (2012)

An amperometric enzyme biosensor for continuous detection of cellobiose has been implemented as an enzyme assay for cellulases. We show that the initial kinetics for cellobiohydrolase I, Cel7A from Trichoderma reesei, acting on different types of cellulose substrates, semi-crystalline and amorphous, can be monitored directly and in real-time by an enzyme-modified electrode based on cellobiose dehydrogenase (CDH) from Phanerochaete chrysosporium (Pc). PcCDH was cross-linked and immobilized on the surface of a carbon paste electrode which contained a mediator, benzoquinone. An oxidation current of the reduced mediator, hydroquinone, produced by the CDH-catalyzed reaction with cellobiose, was recorded under constant-potential amperometry at +0.5 V (vs. Ag/AgCl). The CDH-biosensors showed high sensitivity (87.7 µA mM(-1) cm(-2)), low detection limit (25 nM), and fast response time (t(95%) ≈ 3 s) and this provided experimental access to the transient kinetics of cellobiohydrolases acting on insoluble cellulose. The response from the CDH-biosensor during enzymatic hydrolysis was corrected for the specificity of PcCDH for the β-anomer of cello-oligosaccharides and the approach were validated against HPLC. It is suggested that quantitative, real-time data on pure insoluble cellulose substrates will be useful in attempts to probe the molecular mechanism underlying enzymatic hydrolysis of cellulose.
Verifying analog oscillator circuits using forward/backward abstraction refinement (2006)

Properties of analog circuits can be verified formally by partitioning the continuous state space and applying hybrid system verification techniques to the resulting abstraction. To verify properties of oscillator circuits, cyclic invariants need to be computed. Methods based on forward reachability have proven to be inefficient and in some cases inadequate in constructing these invariant sets. In this paper, we propose a novel approach combining forward- and backward-reachability while iteratively refining partitions at each step. The technique can yield dramatic memory and runtime reductions. We illustrate the effectiveness by verifying, for the first time, the limit cycle oscillation behavior of a third-order model of a differential VCO circuit
Alignment and orientation of N2 scattered from Ag(111) (1987)

The measurement of the alignment and orientation of nitrogen scattered from Ag(111) is reported. Pulsed supersonic beam of nitrogen is scattered off a clean Ag(111) crystal and the scattered nitrogen is detected by two−photon resonant four−photon ionization.(AIP)
Mechanobiological model to study the influence of screw design and surface treatment on osseointegration (2021)

This study aims at suggesting a new approach to peri-implant healing models, providing a set of taxis-diffusion-reaction equations under the combined influence of mechanical and biochemical factors. Early events of osseointegration were simulated for titanium screw implants inserted into a pre-drilled trabecular bone environment, up to 12 weeks of peri-implant bone healing. Simulations showed the ability of the model to reproduce biological events occurring at the implant interface through osteogenesis. Implants with shallow healing chamber showed higher proportions of lamellar bone, enhanced by the increase of mechanical stimulation. Osteoconduction was observed through the surface treatment model and similar bone healing patterns compared to <i>in vivo</i> studies.
Data from CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;To assess the potential for CUE-101, a novel therapeutic fusion protein, to selectively activate and expand HPV16 E7&lt;sub&gt;11-20&lt;/sub&gt;-specific CD8&lt;sup&gt;+&lt;/sup&gt; T cells as an off-the shelf therapy for the treatment of HPV16-driven tumors, including head and neck squamous cell carcinoma (HNSCC), cervical, and anal cancers.&lt;/p&gt;Experimental Design:&lt;p&gt;CUE-101 is an Fc fusion protein composed of a human leukocyte antigen (HLA) complex, an HPV16 E7 peptide epitope, reduced affinity human IL2 molecules, and an effector attenuated human IgG1 Fc domain. Human E7-specific T cells and human peripheral blood mononuclear cells (PBMC) were tested to demonstrate cellular activity and specificity of CUE-101, whereas &lt;i&gt;in vivo&lt;/i&gt; activity of CUE-101 was assessed in HLA-A2 transgenic mice. Antitumor efficacy with a murine surrogate (mCUE-101) was tested in the TC-1 syngeneic tumor model.&lt;/p&gt;Results:&lt;p&gt;CUE-101 demonstrates selective binding, activation, and expansion of HPV16 E7&lt;sub&gt;11-20&lt;/sub&gt;-specific CD8&lt;sup&gt;+&lt;/sup&gt; T cells from PBMCs relative to nontarget cells. Intravenous administration of CUE-101 induced selective expansion of HPV16 E7&lt;sub&gt;11-20&lt;/sub&gt;-specific CD8&lt;sup&gt;+&lt;/sup&gt; T cells in HLA-A2 (AAD) transgenic mice, and anticancer efficacy and immunologic memory was demonstrated in TC-1 tumor-bearing mice treated with mCUE-101. Combination therapy with anti-PD-1 checkpoint blockade further enhanced the observed efficacy.&lt;/p&gt;Conclusions:&lt;p&gt;Consistent with its design, CUE-101 demonstrates selective expansion of an HPV16 E7&lt;sub&gt;11-20&lt;/sub&gt;-specific population of cytotoxic CD8&lt;sup&gt;+&lt;/sup&gt; T cells, a favorable safety profile, and &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; evidence supporting its potential for clinical efficacy in an ongoing phase I trial (NCT03978689).&lt;/p&gt;&lt;/div&gt;
Figure S2 from HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors (2023)

&lt;p&gt;Relative levels of SN-38 released from STA-12-8666 or irinotecan by recombinant carboxylesterases (CES) in vitro.&lt;/p&gt;
Miniaturized on chip antenna for inter-chip and intra-chip wireless communication in 90nm CMOS (2012)

A small integrated antenna was designed for the inter-chip and intra-chip communication over the frequency band from 13.5GHz to 18.3GHz. The FR4 substrate is used to improve the gain of the antenna. The gain of the antenna varies between -5.14dB to -2.3dB which is reasonable gain for the inter- and intra-chip communication.
Mitral Valve Surgery With Severe Left Ventricular Dysfunction (2005)

The management of patients with congestive heart failure (CHF) has become an international health care problem. In the ever-aging population, advances in basic cardiac care that have extended the average life expectancy have also left more people living with chronic cardiac disease than ever before. In the United States alone, nearly 4.9 million suffer from heart failure, yet of the 500,000 new patients diagnosed annually, fewer than 3000 are offered transplantation because of limitations of age, comorbid conditions, and donor availability.
Performance evaluation of an energy meter for low-voltage system monitoring (2018)

FIGURE 6. Apex of front tibia, prolateral view. A, Corynoptera armigera sp. n. (holotype). B, C. Corynoptera fera Mohrig &amp; Heller (from Somero). C, C. vagula Tuomikoski (holotype). D, C. fratercula sp. n. (holotype). E, C. robustior sp. n. (holotype). Scale 0.05 mm.
AFM characterization for Gate-All-Around (GAA) devices (2020)

As development of stacked Nanosheet Gate All-Around (GAA) transistor continues as the candidate technology for future nodes, several key process points remain difficult to characterize effectively. With the GAA device strategy, it is critical to have an inline solution that can provide a readout of physical dimensions that have an impact on the threshold voltage (VT) and yield. Metrology challenges for obtaining these metrics arise from increasingly dense arrays coupled with both high aspect ratios, high numbers of correlated parameters, and increasingly complex 3D geometries. Large area metrology structures can be used for 3D parameters’ process monitoring through techniques such as scatterometry and xray diffraction (XRD) which deliver averaged results over that area, but variation impacting specific devices cannot currently be understood without destructive cross-section. Prior work to characterize the dimensions of these GAA devices has primarily featured optical metrology, X-ray metrology, and critical-dimension scanning electron microscopy (CDSEM), but these techniques have their own challenges at the critical process points. Atomic force microscopy (AFM) had not been utilized due to the aspect ratios and small trench widths which were inaccessible to conventional techniques. However, due to recent advances in scanning and novel probe technologies, AFM is well-suited now to solve these local, three-dimensional challenges. Through this study, we demonstrate AFM characterization of a key process point in the GAA process flow for multiple structures with varying channel lengths, after epitaxial (epi) growth along the Si sidewall. The AFM scan results are compared to CDSEM images for top-down corroboration of topography and to other reference metrology for height correlation. The impact of measured variations in epi height to device performance is also reviewed.
Interactive Online Shopping with Personalized Robot Agent (2018)

Recently, the interaction between human and intelligent agents has become an increasingly hot topic. In this area, entertainment has always played a very important role as an essential element in enriching the user experience. At this research we combined Robohon, a new generation of smart robots, to act as a new type of agent to achieve a better shopping experience through interaction with personal computers and human, which we called as tripartite guiding system. A lot of voice and action is used as the main elements to interact with humans. In the process, the intelligent robot acts as a guide to help people with a better shopping experience step by step.
Photoinduced broadening of cholesteric liquid crystal reflectors (2010)

The selective reflection of cholesteric liquid crystals (CLCs) is well-known and has been utilized in a number of dynamic optical applications. This work presents a novel approach to passively (e.g., all-optically) cue reflection notch broadening in photoresponsive CLC formulations based on high helical twisting power (HTP) bis(azo) chiral dopants. The original reflection bandwidth of approximately 100 nm is increased to as much as 1700 nm, by exposing 36 μm thick cells to UV light. The maximum attainable bandwidth is shown to be a function of cell thickness, light intensity, and strongly related to the HTP of the photoresponsive chiral dopants. An all-optical technique of simultaneous UV and green light exposure is demonstrated to trap the reflection notch at a predetermined position and bandwidth.
An S1P1 agonist, ASP4058, as a potential therapeutic candidate for intracranial aneurysm treatment (2018)

Background:
Transvenous lead extraction procedures in women based on ESC-EHRA EORP European Lead Extraction ConTRolled ELECTRa registry: is female sex a predictor of complications? (2019)

The efficacy of TLE was lower in females than males, with a higher rate of periprocedural major complications. The reasons for this difference are probably related to disparities in risk factors in women, including more pronounced leads adherence to the walls of the veins and myocardium. Lead management may be key to the effectiveness of TLE in females.
Overview of the SMS design method applied to imaging optics (2009)

The Simultaneous Multiple Surfaces (SMS) was developed as a design method in Nonimaging Optics during the 90s. Later, the method was extended for designing Imaging Optics. We present an overview of the method applied to imaging optics in planar (2D) geometry and compare the results with more classical designs based on achieving aplanatism of different orders. These classical designs are also viewed as particular cases of SMS designs. Systems with up to 4 aspheric surfaces are shown. The SMS design strategy is shown to perform always better than the classical design (in terms of image quality). Moreover, the SMS method is a direct method, i.e., it is not based in multi-parametric optimization techniques. This gives the SMS method an additional interest since it can be used for exploring solutions where the multiparameter techniques can get lost because of the multiple local minima.
Wireless Bioelectronics Towards Treatment of Glioblastoma Multiforme (2019)

Abstract ‘Bioelectronic therapies’ are defined as treatments that provide therapy via electrical stimulation. As electrochemical signalling is a key communication pathway of the human body, learning and modulating these signals could allow us to regenerate lost functions and restore health where previously regarded impossible. Bioelectronics do not yet fully exploit this possibility as they lack resolution and plasticity to fully merge with biology. We aim to negate these problems by pioneering the development of wireless bioelectronics. One exciting area we hope this can be applied is that of tumour treating fields (TTFs). TTFs apply electric fields to a tumour region, providing a non-invasive anti-mitotic treatment modality. This anti-mitotic behaviour arises due to dipole alignment and di-electrophoresis. However, an understanding of the exact mode of action has not yet been reached. We aim to improve this knowledge by analysing how healthy astrocytes vs glioblastoma cells behave in various electrical systems: comparing ionic currents with electric fields. Furthermore, we hope to improve targeting of TTFs through the in-situ growth of conductive structures, via wireless electrochemistry. Proof of concept has been achieved by wirelessly growing silver micro-wires in the presence of U251 glioblastoma cells. Wire growth has been optimised without the presence of cells, allowing controlled growth direction via electrode geometry. Wires range from 2–9µm in diameter and have been shown to be conductive through the completion of a circuit lighting an LED. Such structures could ultimately be grown in the region of a tumour, therefore therapeutically targeting the electric field to that site.
Metabolomic Analysis of Akt1-Mediated Muscle Hypertrophy in Models of Diet-Induced Obesity and Age-Related Fat Accumulation (2014)

Akt1 is a serine/threonine kinase that promotes cell growth and survival. Previously, Akt1 activation in a double transgenic (DTG) mouse model fed a high-fat/high-sucrose (HF/HS) diet was found to promote type IIb muscle growth and to lead to a significant reduction in obesity. Here, we have used metabolomics to examine the metabolic perturbations in blood serum and liver and gastrocnemius tissues of the DTG mice. Multivariate statistics highlighted consistent metabolic changes in gastrocnemius muscle following Akt1 activation, which included significant reductions of serine and histidine-containing dipeptides (anserine and carnosine), in addition to increased concentrations of phosphorylated sugars. In addition, Akt1-mediated regression in obesity could be associated with increased glycolysis in gastrocnemius muscle as well as increased gluconeogenesis, glycogenolysis, and ketogenesis in the liver. In old DTG animals, Akt1 activation was found to improve glucose metabolism and confer a beneficial effect in the regression of age-related fat accumulation. This study identifies metabolic changes induced by Akt1-mediated muscle growth and demonstrates a cross-talk between distant organs that leads to a regression of fat mass. The current findings indicate that agents that promote Akt1 induction in muscle have utility in the regression of obesity.
The ErbB2-antibody 2C4 and cardiac dysfunction in mice. (2011)

e11040 Background: Anti-ErbB2 therapies are associated with increased risk of left ventricular (LV) dysfunction. Trastuzumab increases the frequency of asymptomatic decrease in LV ejection fraction (LVEF) by 3-18%, and the risk of heart failure (HF) by 2-4%. The newer ErbB2 antibody rhuMAb 2C4 (pertuzumab) seems to affect ligand induced ErbB signaling in a more direct fashion, affecting EGFR/ErbB2 dimerization; yet, its cardiac side effects are only beginning to emerge. Here, we test whether the murine 2C4 induces cardiac dysfunction in normal mice. Methods: In vivo cardiac function was measured with LV fractional shortening (FS) by M-mode echocardiography in sedated C57BL/6 mice (2-4 mo. old) at day 0, and after 2 and 6 days of daily i.p. administration of 2C4 (2.25 μg/g/day) or doxorubicin (Doxo, 2.17 μg/g/day) as a positive control, and in sham animals. With Speckle Tracking echocardiography (ST) we also evaluated radial myocardial strain (%), a very sensitive parameter which can predict LV dysfunction. Results: After 2 days, FS was reduced with 2C4: 58±1%, p=.01 vs sham (60±0.4%). The reduction in FS obtained with Doxo was even larger: 52±0.2%, p=.0000001 vs sham, p=.00004 vs 2C4. Myocardial strain was similarly reduced in both 2C4 (40±8%) and Doxo-treated mice (43±3%) compared to sham (66±0.6%; p=.02 vs 2C4, and p=.0005 vs Doxo). After 6 days, LV dysfunction was exacerbated, with FS further reduced to similar values by 2C4 (39±5%) and Doxo (46±2%, p=NS vs 2C4; both p<.05 vs sham and vs 2 days), and strain decreased to 31±7% (2C4) and 40±7% (Doxo, p=NS vs 2C4; both p=.01 vs sham and p=NS vs 2 days). Conclusions: The murine ErbB2 antibody 2C4 is cardiotoxic in mice. The reduction in FS is milder than Doxo early at 2 days, but comparable to Doxo after 6 days. The clear mechanisms of anti ErbB2-induced cardiotoxicity are to be elucidated. Further studies will be crucial to establish the cardiotoxic mechanisms of ErbB2-antagonists, and to influence the design of future anticancer therapies in an attempt to retain anticancer effects, while minimizing cardiac toxicity. We also plan to apply speckle tracking echocardiography to clinical studies, in order to evaluate the impact of early identification of ErbB2-blockers cardiotoxicity in the treatment of women with breast cancer.
Self-healing in multi-constrained multi-actor virtualization orchestration (2018)

Multi-constrained multi-provider orchestration is alone challenging, which we complemented with an automated multi-layered failure recovery mechanism. Our proof of concept prototype demonstrates information models (both bottom-up and top-down), orchestration and recovery workflows with delegation, trial and error based backtracking among the chain of federated providers in an Industry 4.0 use-case for critical machine type communication (C-MTC). With a remote factory scenario, we show fault recovery from single to multi provider involvement. We provide insights into the responsibility split for failure handling between service agnostic resource orchestration and service specific lifecycle management components.
Early Stages of Feline Immunodeficiency Virus Infection in Lymph Nodes and Spleen (1994)

Analysis of the early stages of infection within the lymphoid organs is crucial for the understanding of the physiopathology of HIV infection. Such analysis can only be performed using animal models. Cats were infected with two strains of FIV and killed at regular intervals for a classic pathologic study along with a quantification of the viral load by in situ hybridization in the spleen and the lymph nodes. The pathological study showed a persistent follicular reaction, which peaked 15 days postinoculation (p.i.). The in situ hybridization study showed two types of labeling. The first was spot labeling corresponding to cells actively replicating the virus. The second consisted of a more diffuse labeling linked to the follicular dendritic cells (FDCs) demonstrating by colocalization of virus detected by in situ hybridization associated with the FDCs, specifically labeled by immunohistochemistry. The number of productive cells is few and identical for the two viruses tested. Despite a slight peak at 15 days p.i., the number of infected cells persists while slightly decreasing over time. The FDC virus load appears jointly with the appearance of antibody and remains permanent until the end of the study at 3 years p.i. These results show that in the FIV model, there is a chronic permanent infection in the lymphoid organs. Furthermore, as compared with the SIV-macaque model, there is a correlation between the low number of infected cells detected in these organs in the early phase and the extended length of the asymptomatic period, which contrasts with the high level of the FDC virus load lasting during the same period.