gebhart/patrepeval huggingface dataset:
Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts (2019)

Cancer-associated fibroblasts (CAFs), one of the major components of a tumour microenvironment, comprise heterogeneous populations involved in tumour progression. However, it remains obscure how CAF heterogeneity is governed by cancer cells. Here, we show that cancer extracellular vesicles (EVs) induce a series of chemokines in activated fibroblasts and contribute to the formation of the heterogeneity. In a xenograft model of diffuse-type gastric cancer, we showed two distinct fibroblast subpopulations with alpha-smooth muscle actin (α-SMA) expression or chemokine expression. MicroRNAs (miRNAs) profiling of the EVs and the transfection experiment suggested that several miRNAs played a role in the induction of chemokines such as CXCL1 and CXCL8 in fibroblasts, but not for the myofibroblastic differentiation. Clinically, aberrant activation of CXCL1 and CXCL8 in CAFs correlated with poorer survival in gastric cancer patients. Thus, this link between chemokine expression in CAFs and tumour progression may provide novel targets for anticancer therapy.
Ab-intio based electron-phonon scattering for 2D materials within the NEGF framework (2021)

For the last 15 years, two-dimensional (2D) materials are being actively studied as a possible replacement for silicon. Due to their layered nature, the materials can be scaled down to a single atomic layer, favouring extreme device scaling. In addition, surface effects such as roughness, dangling bonds, and interface states are also reduced/eliminated [1],[2]. Besides, these materials confine charge carriers to atomic-thin layers, which provides excellent gate-control and reduces short-channel effects [3]. Graphene (single layer graphite) was the first of the 2D material to be isolated, and very high electron mobility $(\gt 10^{5}$ cm$^{2} /$Vs) in its suspended state was reported [4]. However, it does not have a bandgap, which is a severe limitation for transistor applications (challenging to turn off the device). Still, it initiated the discovery of other 2D materials with a band gap, such as phosphorene (mono- or few-layer black phosphorous) [5] and transition metal dichalcogenides (TMDs) [6]. However, TMDs and phosphorene are found to have lower intrinsic mobility when compared to graphene [7],[8]. This can be attributed to the large electron-phonon scattering present in these materials. Theoretical calculations have predicted that, even in 2D material-based transistors of channel lengths as small as about 5 nm, electron-phonon scattering plays a significant role [9],[10].
Method for the determination of the compacta area and the mean absorption density of human bones (1975)

Here we report a 3-year and 7-month-old boy with a muscular ventricular septal defect at the apex. At age 7 months, pulmonary artery banding was performed. Surgical treatment consisted of double patch closure via septal ventriculotomy and a main pulmonary artery plasty by an end-to-end anastomosis with cardiopulmonary bypass. There was no residual leak of the ventricular septal defect or ventricular aneurysm and the postoperative course was good. This technique could be a useful surgical option for repair of apical muscular ventricular septal defects.
Electron Transfer Photoreduction of 5,7-Diiodo-3-butoxy-6-fluorone with Tetrabutylammonium Triphenylbutylborate and N,N-Dimethyl-2,6-diisopropylaniline (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron Transfer Photoreduction of 5,7-Diiodo-3-butoxy-6-fluorone with Tetrabutylammonium Triphenylbutylborate and N,N-Dimethyl-2,6-diisopropylanilineSalah Hassoon and D. C. NeckersCite this: J. Phys. Chem. 1995, 99, 23, 9416–9424Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/j100023a018https://doi.org/10.1021/j100023a018research-articleACS PublicationsRequest reuse permissionsArticle Views288Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre–B ALL (2017)

Inactivation of the tumor suppressor gene encoding the transcriptional regulator Ikaros (<i>IKZF1</i>) is a hallmark of BCR-ABL1<sup>+</sup> precursor B cell acute lymphoblastic leukemia (pre-B ALL). However, the mechanisms by which Ikaros functions as a tumor suppressor in pre-B ALL remain poorly understood. Here, we analyzed a mouse model of BCR-ABL1<sup>+</sup> pre-B ALL together with a new model of inducible expression of wild-type Ikaros in <i>IKZF1</i> mutant human BCR-ABL1<sup>+</sup> pre-B ALL. We performed integrated genome-wide chromatin and expression analyses and identified Ikaros target genes in mouse and human BCR-ABL1<sup>+</sup> pre-B ALL, revealing novel conserved gene pathways associated with Ikaros tumor suppressor function. Notably, genetic depletion of different Ikaros targets, including <i>CTNND1</i> and the early hematopoietic cell surface marker CD34, resulted in reduced leukemic growth. Our results suggest that Ikaros mediates tumor suppressor function by enforcing proper developmental stage-specific expression of multiple genes through chromatin compaction at its target genes.
Al-2.37 Dissolution Promoter (2021)

As increasingly smaller molecular materials and material structures are devised or developed for technological applications, the demands on the processes of lithography now routinely include feature sizes that are of the order of 10 nm. In reaching such a fine level of resolution, the methods of lithography have increased markedly in sophistication and brought into play 2terminology that is unfamiliar, on the one hand, to scientists tasked with the development of new lithographic materials or, on the other, to the engineers who design and operate the complex equipment that is required in modern-day processing. Publications produced by scientists need to be understood by engineers and vice versa, and these commonly arise from collaborative research that draws heavily on the terminology of two or more of the traditional disciplines. It is developments in polymer science and material science that lead progress in areas that cross traditional boundaries, such as microlithography. This document provides the exact definitions of a selection of unfamiliar terms that researchers and practitioners from different disciplines might encounter.
Reduction of Haematite Using Hydrogen Thermal Plasma (2019)

The development of hydrogen plasma smelting reduction as a CO2 emission-free steel-making process is a promising approach. This study presents a concept of the reduction of hematite using hydrogen thermal plasma. A laboratory scale and pilot scale hydrogen plasma smelting reduction (HPSR) process are introduced. To assess the reduction behavior of hematite, a series of experiments has been conducted and the main parameters of the reduction behavior, namely the degree of hydrogen utilization, degree of reduction and the reduction rate are discussed. The thermodynamic aspect of the hematite reduction is considered and the pertinent calculations have been carried out using FactSageTM 7.2. The degree of hydrogen utilization and the degree of reduction were calculated using the off-gas chemical composition. The contribution of carbon, introduced from the graphite electrode, ignition pin and steel crucible, to the reduction reactions was studied. The degree of reduction of hematite, regarding H2O, CO and CO2 as the gaseous reduction products, is determined. It is shown that the degree of hydrogen utilization and the reduction rate were high at the beginning of the experiments, then decreased during the reduction process owing to the diminishing of iron oxide. Conducting experiments with the high basicity of slag B2=2 led to a decrease of the phosphorus concentration in the produced iron.
A New Conducting Polymer for Lithium-Ion Batteries (2020)

A new electroconductive polymer based on a nickel complex with N4 Schiff base has been synthesized for the first time. Electrochemical properties of this material and the nature of charge carriers have been studied. The possibility of using this polymer as a functional component of cathodes in lithium-ion batteries is demonstrated.
643: Enhance Chemosensitization of Gemcitabine Using Antisense Oligonucleotides Targeting Clusterin for the Treatment of Bladder Cancer (2006)

You have accessJournal of UrologyDiscussed Poster, Monday, May 22, 2006, 9:00 am - 12:00 pm1 Apr 2006643: Enhance Chemosensitization of Gemcitabine Using Antisense Oligonucleotides Targeting Clusterin for the Treatment of Bladder Cancer Tony Luongo, Liana Adam, Wassim Kassouf, Alan So, Martin E. Gleave, and Colin P.N. Dinney Tony LuongoTony Luongo More articles by this author , Liana AdamLiana Adam More articles by this author , Wassim KassoufWassim Kassouf More articles by this author , Alan SoAlan So More articles by this author , Martin E. GleaveMartin E. Gleave More articles by this author , and Colin P.N. DinneyColin P.N. Dinney More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)32889-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "643: Enhance Chemosensitization of Gemcitabine Using Antisense Oligonucleotides Targeting Clusterin for the Treatment of Bladder Cancer." The Journal of Urology, 175(4S), p. 207 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 207 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Tony Luongo More articles by this author Liana Adam More articles by this author Wassim Kassouf More articles by this author Alan So More articles by this author Martin E. Gleave More articles by this author Colin P.N. Dinney More articles by this author Expand All Advertisement PDF downloadLoading ...
Alignment in total knee arthroplasty (2020)

Dissatisfaction following total knee arthroplasty is a well-documented phenomenon. Although many factors have been implicated, including modifiable and nonmodifiable patient factors, emphasis over the past decade has been on implant alignment and stability as both a cause of, and a solution to, this problem. Several alignment targets have evolved with a proliferation of techniques following the introduction of computer and robotic-assisted surgery. Mechanical alignment targets may achieve mechanically-sound alignment while ignoring the soft tissue envelope; kinematic alignment respects the soft tissue envelope while ignoring the mechanical environment. Functional alignment is proposed as a hybrid technique to allow mechanically-sound, soft tissue-friendly alignment targets to be identified and achieved. Cite this article: <i>Bone Joint J</i> 2020;102-B(3):276-279.
Etude expérimentale de la stabilité d’une flamme dans une chambre de combustion aéronautique par recirculation de gaz brûlés et par ajout d’hydrogène (2012)

Physical and chemical strategies that place designed molecules in spatially separated regions of surfactant-templated mesostructured silicate thin films are used to prepare films containing rhodamine 6G (R6G), lanthanide complexes, and both simultaneously. Fluorescence and photoexcitation spectra of R6G in amorphous and structured thin films show that it is located inside the surfactant micelles of structured thin films. A silylated ligand that binds lanthanides condenses to form part of the silica framework and causes the lanthanide to localize in the silica. Luminescence and photoexcitation spectra show that energy transfer from the metal complex to R6G occurs in the films. R6G quenches Tb emission in a concentration-dependent manner. Energy transfer efficiency is calculated using the Tb luminescence lifetime, and this quantity is used to calculate the distance between Tb and R6G with the aid of Forster theory.
Mineralization and optical characterization of copper oxide nanoparticles using a high aspect ratio bio-template (2014)

Organized chains of copper oxide nanoparticles were synthesized, without palladium (Pd) activation, using the M13 filamentous virus as a biological template. The interaction of Cu precursor ions with the negatively charged viral coat proteins were studied with Fourier transform infrared spectroscopy, transmission electron microscopy, and energy dispersive x-ray spectroscopy. Discrete nanoparticles with an average diameter of 4.5 nm and narrow size distribution were closely spaced along the length of the high aspect ratio templates. The synthesized material was identified as a mixture of cubic Cu2O and monoclinic CuO. UV/Vis absorption measurements were completed and a direct optical band gap of 2.87 eV was determined using Tauc's method. This value was slightly larger than bulk, signaling quantum confinement effects within the templated materials.
How much can hardware help routing? (1993)

We study the extent to which complex hardware can speed up routing. Specifically, we consider the following questions. How much does adaptive routing improve over oblivious routing? How much does randomness help? How does it help if each node can have a large number of neighbors? What benefit is available if a node can send packets to several neighbors within a single time step? Some of these features require complex networking hardware, and
High-Repetition-Rate Multi-Millijoule Femtosecond 2.1-μm Ho:YAG Laser (2013)

Femtosecond Ho:YAG room-temperature CPA system delivering scalable multi-mJ multi-kHz pulses with a bandwidth exceeding 12 nm and average power of 15 W is presented. Broadband white light generation with the recompressed 530-fs pulses is demonstrated.
Tremelimumab: A monoclonal antibody against CTLA-4—In combination with radiofrequency ablation (RFA) in patients with biliary tract carcinoma (BTC). (2017)

316 Background: Tremelimumab is a fully human monoclonal antibody that binds to CTLA-4 expressed on the surface of activated T lymphocytes and results in inhibition of B7-CTLA-4-mediated downregulation of T-cell activation. Radiofrequency ablation (RFA) has been shown to induce a peripheral immune response which may enhance the effect of anti-CTLA4 treatment. Methods: Patients with refractory BTC were enrolled in a study of monthly Tremelimumab (10mg/kg, 6 doses) combined with RFA (to one lesion) performed on week 6. Tumor biopsies were performed at time of RFA with regular PBMC collection for intensive immunemontoring. Results: 17 pts enrolled. Characteristics: M:F 8:9; Median age 57(range 36-67); BTC subtype - intrahepatic/exrahepatic: 12/5. 13/17 had metastatic disease. All pts were chemorefractory with 12/17 having received at least 2 regimens. While on study, 6 pts had early PD within 6 weeks; 11 were able to undergo RFA. No DLT encountered. Most common toxicity was pruritus. There were no objective responses. Of evaluable pts N = 6 (55%) had stable disease as a best response. Conclusions: Tremelimumab in combination with subtotal RFA in patients with advanced BTC is safe and feasible. No objective responses have so far been seen in this predominantly primary intrahepatic BTC population. Full efficacy and immune monitoring data will be presented. Clinical trial information: NCT01853618.
Correlation of ABI1 and PTEN expression during prostate tumor progression. (2022)

172 Background: Mechanisms of tumor invasion are not well defined. PTEN, a key tumor suppressor frequently inactivated in epithelial cancers, acts as a central node that controls tumor invasion. Despite PI-3 kinase-phospho-Akt pathway activation resulting in enhanced tumor growth, prostate tumors with PTEN loss undergo p53-mediated senescence that restricts tumor invasion. Methods: ABI1 downregulation is associated with epithelial-mesenchymal transition in highly invasive prostate tumors; these tumors frequently loose PTEN; therefore we set to examine genetic interaction of ABI1 and PTEN using novel mouse model of prostate cancer. We analyzed the correlation of ABI1 and PTEN expression in human PCa tumor tissue. Results: Here, using Abi1/Pten KO mouse model we identified a novel mechanism that guards tumor invasion. In Pten-null tumors upregulation of Abi1 leads to sequestration of activated Src kinase. In the absence of Abi1, this regulation is lost leading to activation of non-canonical WNT-SRC-STAT3 axis and enhanced invasion through activation of MMP2 activity. This molecular mechanism explains progression of tumors with Pten loss from PIN to invasive carcinoma upon concomitant Abi1 inactivation. In human tumors with low Abi1 and Pten are associated with aggressive phenotype, biochemical recurrence and metastasis. Conclusions: ABI1 acts as failsafe mechanism in PTEN null tumors by restricting SRC-mediated tumor invasion. ABI1 might have a predictive value in clinical setting in context of PTEN levels.
Eradication of Helicobacter pylori Prevents Recurrence of Ulcer After Simple Closure of Duodenal Ulcer Perforation (2000)

Eradication of H. pylori prevents ulcer recurrence in patients with H. pylori-associated perforated duodenal ulcers. Immediate acid-reduction surgery in the presence of generalized peritonitis is unnecessary.
Introduction of acis-Prolyl Mimic in Position 7 of the Peptide Hormone Oxytocin Does Not Result in Antagonistic Activity (2005)

New insights into the structure-activity relationship of the peptide hormone oxytocin are presented. Incorporation of the novel cis-prolyl mimic 2,2-dimethyl-1,3-thiazolidine-4-carboxylic acid (pseudoproline, PsiPro) at position 7 of the hormone yielded the analogue [Cys(Psi(Me,Me)pro)]7oxytocin (1) that showed a 92-95% induction of the cis peptide bond conformation between Cys6 and PsiPro7, as determined by one- and two-dimensional NMR spectra in water and in DMSO-d6. The impact of the dimethyl moiety regarding conformation and bioactivity was investigated by the synthesis of the corresponding dihydro compound, [Cys(Psi(H,H)pro)]7oxytocin (2). Biological tests of the uterotonic activity, the pressor activity, and the binding affinity to the rat and human oxytocin receptors were carried out. As a most significant result, no antagonistic activities were found for both the cis-constrained analogue 1 and analogue 2, suggesting that a cis conformation between residues 6 and 7 of the molecule does not result in antagonistic activity. However, the about 10-fold reduction in agonistic activity of 1 as compared to oxytocin is consistent with the reduction of the trans conformation from 90% for oxytocin to 5-8% for compound 1. Compound 1 retained a high binding affinity for the oxytocin receptor, with K(i) values of 8.0 and 1.9 nM for the rat and the human receptor, respectively. The correlation between the biological activities and the cis contents obtained from NMR analysis for compounds 1, 2, and oxytocin leads to the hypothesis that a cis/trans conformational change plays an important role in oxytocin receptor binding and activation.
Sequential/Session-based Recommendations (2022)

In recent years, sequential recommender systems (SRSs) and session-based recommender systems (SBRSs) have emerged as a new paradigm of RSs to capture users' short-term but dynamic preferences for enabling more timely and accurate recommendations. Although SRSs and SBRSs have been extensively studied, there are many inconsistencies in this area caused by the diverse descriptions, settings, assumptions and application domains. There is no work to provide a unified framework and problem statement to remove the commonly existing and various inconsistencies in the area of SR/SBR. There is a lack of work to provide a comprehensive and systematic demonstration of the data characteristics, key challenges, most representative and state-of-the-art approaches, typical real- world applications and important future research directions in the area. This work aims to fill in these gaps so as to facilitate further research in this exciting and vibrant area.
Genome-wide DNA methylation profile of early-onset endometrial cancer: its correlation with genetic aberrations and comparison with late-onset endometrial cancer (2019)

Abstract The present study was performed to clarify the significance of DNA methylation alterations during endometrial carcinogenesis. Genome-wide DNA methylation analysis and targeted sequencing of tumor-related genes were performed using the Infinium MethylationEPIC BeadChip and the Ion AmpliSeq Cancer Hotspot Panel v2, respectively, for 31 samples of normal control endometrial tissue from patients without endometrial cancer and 81 samples of endometrial cancer tissue. Principal component analysis revealed that tumor samples had a DNA methylation profile distinct from that of control samples. Gene Ontology enrichment analysis revealed significant differences of DNA methylation at 1034 CpG sites between early-onset endometrioid endometrial cancer (EE) tissue (patients aged ≤40 years) and late-onset endometrioid endometrial cancer (LE) tissue, which were accumulated among ‘transcriptional factors’. Mutations of the CTNNB1 gene or DNA methylation alterations of genes participating in Wnt signaling were frequent in EEs, whereas genetic and epigenetic alterations of fibroblast growth factor signaling genes were observed in LEs. Unsupervised hierarchical clustering grouped EE samples in Cluster EA (n = 22) and samples in Cluster EB (n = 12). Clinicopathologically less aggressive tumors tended to be accumulated in Cluster EB, and DNA methylation levels of 18 genes including HOXA9, HOXD10 and SOX11 were associated with differences in such aggressiveness between the two clusters. We identified 11 marker CpG sites that discriminated EB samples from EA samples with 100% sensitivity and specificity. These data indicate that genetically and epigenetically different pathways may participate in the development of EEs and LEs, and that DNA methylation profiling may help predict tumors that are less aggressive and amenable to fertility preservation treatment.
Supplemental Table 3 from Response to Neoadjuvant Targeted Therapy in Operable Head and Neck Cancer Confers Survival Benefit (2023)

&lt;p&gt;Comparison of clinical to pathologic stage migration between patients enrolled in 1 of 4 window trials compared to a second control group&lt;/p&gt;