gebhart/patrepeval huggingface dataset:
Aufbereitung von Polymerschmelzen mit anderen Apparaten und Maschinen (2019)

No AccessPolymer-Aufbereitung und Kunststoff-CompoundierungOct 2019Aufbereitung von Polymerschmelzen mit anderen Apparaten und MaschinenKlemens Kohlgrüber, Michael Bierdel, Harald RustKlemens KohlgrüberSearch for more papers by this author, Michael BierdelSearch for more papers by this author, Harald RustSearch for more papers by this authorhttps://doi.org/10.3139/9783446460799.007SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2019Pages: 529-628Print ISBN: 978-3-446-45832-1eISBN: 978-3-446-46079-9 Copyright & Permissions© 2019 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
beta-Hydroxyaspartic acid and beta-hydroxyasparagine residues in recombinant human protein S are not required for anticoagulant cofactor activity or for binding to C4b-binding protein. (1991)

Among the vitamin K-dependent plasma proteins, only protein S contains the post-translationally modified amino acid erythro-beta-hydroxyasparagine (Hyn). Protein S also contains erythro-beta-hydroxyaspartic acid (Hya). The function of these unusual amino acids, located in the epidermal growth factor-like domains, is unknown. To determine if these post-translational modifications contribute to the functional integrity of human protein S (HPS), recombinant human protein S lacking Hya and Hyn (rHPSdesHya/Hyn) was purified from the medium of human kidney 293 cells that were transfected with HPS cDNA and grown in the presence of the hydroxylase inhibitor 2,2'-dipyridyl. Solution-phase equilibrium binding studies revealed that rHPSdesHya/Hyn binds C4b-binding protein (C4BP) in a manner indistinguishable from recombinant HPS and plasma-derived HPS, exhibiting a Kd in the presence of 2 mM CaCl2 of approximately 0.7 nM and a Kd in the presence of 4 mM EDTA approximately 10-fold higher. In a purified component system, rHPSdesHya/Hyn displayed normal anticoagulant cofactor activity in the activated protein C-catalyzed inactivation of coagulation factor Va bound in the prothrombinase complex. In addition, digestion of rHPSdesHya/Hyn with thrombin in the presence of EDTA appeared normal, and 2 mM CaCl2 prevented the cleavage. Together these results suggest that the post-translational modifications of Asn and Asp residues are not necessary for the macromolecular or Ca2+ interactions associated with the anticoagulant and C4BP binding characteristics of HPS.
Machining Performance of Brazed Diamond Wire Saw with Optimum Grain Distribution (2006)

A kind of new monolayer brazed diamond wire saw with both chemical bonding at the interface between diamond grits and brazing alloy and optimum grits distribution was made. And a machining performance comparative experiment was carried out between the sintered diamond saw from Italy and the brazed one mentioned above. The sawn material is marble with middle hardness. The testing results show that the wire saw with a brazed bonding diamond grid can achieve two to three times the working efficiency of conventional sintered diamond saw, and the corresponding service life can do 3~4 times. Furthermore, the grits of the brazed diamond wire fail mainly in micro fracture modes other than pull-out ones of the sintered diamond saw grits, indicating the strong retention of brazing alloy to the diamond grits. Almost no grits pulling out for brazed diamond wire saw is the key factor of its longer service life, and the optimum distribution and micro fracture of the brazed diamond wire grits raise the machining efficiency.
Classroom demonstrations: Learning tools or entertainment? (2004)

We compared student learning from different modes of presenting classroom demonstrations to determine how much students learn from traditionally presented demonstrations, and whether learning can be enhanced by simply changing the mode of presentation to increase student engagement. We find that students who passively observe demonstrations understand the underlying concepts no better than students who do not see the demonstration at all, in agreement with previous studies. Learning is enhanced, however, by increasing student engagement; students who predict the demonstration outcome before seeing it, however, display significantly greater understanding.
Correlated Randomized Benchmarking (2020)

To improve the performance of multi-qubit algorithms on quantum devices it is critical to have methods for characterizing non-local quantum errors such as crosstalk. To address this issue, we propose and test an extension to the analysis of simultaneous randomized benchmarking data -- correlated randomized benchmarking. We fit the decay of correlated polarizations to a composition of fixed-weight depolarizing maps to characterize the locality and weight of crosstalk errors. From these errors we introduce a crosstalk metric which indicates the distance to the closest map with only local errors. We demonstrate this technique experimentally with a four-qubit superconducting device and utilize correlated RB to validate crosstalk reduction when we implement an echo sequence.
Fatality Resulting from Methylphenidate Overdose (1986)

A case involving an accidental overdose fatality resulting from an intravenous injection of crushed Ritalin (methylphenidate) tablets is presented. The drug was quantified by gas chromatography/nitrogen-phosphorus detection and confirmed by gas chromatography/mass spectrometry. Concentrations of drug were as follows: blood, 2.8 mg/L; bile, 5.7 mg/L; kidney, 3.0 mg/kg; liver, 2.1 mg/kg; and stomach contents, 1.6 mg total. Other drugs and volatile substances were not detected.
Differences between physical therapist ratings, self-ratings, and posturographic measures when assessing static balance exercise intensity (2023)

These preliminary findings suggested that self-ratings best indicated two intensity levels (i.e., higher/lower) and sway kinematics were most reliable at intensity extremes.
ACQUA: Adaptive and cooperative quality-aware control for automotive cyber-physical systems (2017)

Controllers in cyber-physical systems integrate a design-time behavioral model of the system under design to improve their own quality. In the state-of-the-art control designs, behavioral models of other interacting neighbor systems are also integrated to form a centralized behavioral model and to enable a system-level optimization and control. Although this ideal embedded control design may result in pareto-optimal solutions, it is not scalable to larger number of systems. Moreover, the behavior of the multi-domain physical systems may be too complex for a control designer to model and may dynamically change at run time. In this paper, we propose a novel Adaptive and Cooperative Quality-Aware (ACQUA) control design which addresses these challenges. In this control design, an ACQUA-based controller for the system under design will monitor the quality of the neighbor systems to dynamically learn their behavior. Therefore, it can quickly adapt its control to cooperate with other neighbor controllers for improving the quality of not only itself, but also other neighbor systems. We apply ACQUA to design a cooperative controller for automotive navigation system, motor control unit, and battery management system in an electric vehicle. We use this automotive example to analyze the performance of the design. We show that by using our ACQUA control, we can reach up to 86% improvements achievable by an ideal embedded control design such that energy consumption reduces by 18% and battery capacity loss decreases by 12% compared to the state-of-the-art on average.
The Experimental Study on Mixing Characteristics in a Square Subchannel Geometry with Typical Flow Deflectors (2008)

The lateral flow structures in a subchannel geometry were carefully examined in an enlarged 5 × 5 rod bundle array by using a two-color LDA system. The detailed measurement data of lateral velocities in subchannels have been obtained as fabricating the rod bundle array 2.6 times larger than the real bundle size. Two types of flow deflectors were selected for the test: a conventional split-type mixing vane and a swirl-type vane that had been designed to enhance the swirling flow in a subchannel. Experiments were performed in a cold test loop facility at KAERI. The experimental conditions were normal pressure (1.5 bar) and temperature (35°C). The average axial velocity was maintained at 1.5 m/s and was equivalent to Re = 50,000. From the experimental results, specific flow characteristics for each vane types were observed.
Strains and stresses around implantation boundaries in bubble materials: Elastic model and experimental determination (1984)

An elastic model, based on distributions of dislocations, of the stress-strain distribution around implantation boundaries in bubble materials is presented. X-ray imaging under conditions of plane wave illumination serves to check upon the general validity of the model. Finally, the distribution of stress-induced easy magnetization directions around non implanted patterns is discussed.
Dynamic-Structure Resource Block Allocation Based Scheduling for 5G Systems (2022)

We propose an efficient radio resource scheduling (RRS) approach based on the existing dynamic resource block structure (D-RBS). The proposed RRS is more responsive to variations in traffic demand. More specifically, small-sized resource blocks (RB)s are allocated to user equipments (UE)s to handle the changes in the traffic needs and link failures. The proposed approach enables low latency communication without the use of punctured mini-slot based scheduling methods. Thus, the performance of enhanced mobile broadband (eMBB) UEs or cells is not degraded while prioritizing ultra-reliable low latency communication (URLLC) UEs. The available RBs are distributed using traditional scheduling algorithms such as round robin (RR), proportional fair (PF), and best channel quality indicator (BCQI). Also, the proposed scheme allows the dynamic switching of RR and BCQI scheduling based on specific thresholds, such as signal-to-noise ratio (SNR) values. System-level simulations (SLS)s are performed to evaluate the performance of the proposed approach against the conventional static resource block structure (S-RBS) approach. The simulation results demonstrate that the developed approach provides robust data rate, system throughput, spectral efficiency (SE), and achievable rate per UE for various fifth generation (5G) services.
Low dose cytarabine monotherapy for myelodysplastic syndromes (2016)

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The main objective of this systematic review is to evaluate the efficacy and safety of low dose cytarabine for patients with MDS.
ChemInform Abstract: A Concise Synthesis of neo‐Inositol. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Datacatcher Vimeo Channel (2017)

Datacatchers are custom-built, location-aware devices that stream messages about the area they are in. Derived from a large number of ‘big data’ sources, the messages simultaneously draw attention to the socio-political topology of the lived environment and to the nature of big data itself. The Studio produced 130 bespoke devices as part of our ongoing programme to explore how people appropriate and make sense of open-ended designs. They are research devices that are designed both to embody our conjectures about certain issues and to act as tools helping us to further investigate peoples’ orientations around those issues. We deployed the Datacatchers to volunteers recruited at local markets and car-boot sales, and commissioned filmmakers to produce short video documentaries of their experiences. The resulting films – over 2.5 hours in total – are available at https://vimeo.com/channels/datacatcher
Effects of allyl methyl trisulfide on glutathioneS‐transferase activity and BP‐induced neoplasia in the mouse (1986)

Allyl methyl trisulfide (AMT), a constituent of garlic oil, was studied for its effects on glutathione S-transferase (GST) activity and on benzo[a]pyrene (BP)-induced neoplasia of the forestomach and lungs of female A/J mice. AMT induced increased GST activity in the forestomach, small bowel mucosa, liver, and lung. The forestomach and small bowel mucosa responded to a single low dose of AMT (3.0 mumol) given by oral intubation, whereas liver and lung were less reactive. A dose schedule of two administrations of 15 mumol AMT given 48 hours apart gave close-to-maximum induction in all four tissues and was chosen for investigation of its inhibitory effects. With this dose schedule, AMT produced an inhibition of BP-induced neoplasia of the forestomach as shown by a greater than 70% reduction in the number of tumors found at the completion of the experiment. Inhibition of pulmonary neoplasia did not occur. AMT is a member of a new class of naturally occurring chemicals that have the capacity to inhibit chemical carcinogenesis.
Mode-division multiplexed transmission with inline few-mode fiber amplifier (2012)

We demonstrate mode-division multiplexed WDM transmission over 50-km of few-mode fiber using the fiber's LP01 and two degenerate LP11 modes. A few-mode EDFA is used to boost the power of the output signal before a few-mode coherent receiver. A 6×6 time-domain MIMO equalizer is used to recover the transmitted data. We also experimentally characterize the 50-km few-mode fiber and the few-mode EDFA.
Data from Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with high mortality and a lack of targeted therapies. To identify and prioritize druggable targets, we performed genome analysis together with genome-scale siRNA and oncology drug profiling using low-passage tumor cells derived from a patient with treatment-resistant HPV-negative HNSCC.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; A tumor cell culture was established and subjected to whole-exome sequencing, RNA sequencing, comparative genome hybridization, and high-throughput phenotyping with a siRNA library covering the druggable genome and an oncology drug library. Secondary screens of candidate target genes were performed on the primary tumor cells and two nontumorigenic keratinocyte cell cultures for validation and to assess cancer specificity. siRNA screens of the kinome on two isogenic pairs of p53-mutated HNSCC cell lines were used to determine generalizability. Clinical utility was addressed by performing drug screens on two additional HNSCC cell cultures derived from patients enrolled in a clinical trial.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Many of the identified copy number aberrations and somatic mutations in the primary tumor were typical of HPV(−) HNSCC, but none pointed to obvious therapeutic choices. In contrast, siRNA profiling identified 391 candidate target genes, 35 of which were preferentially lethal to cancer cells, most of which were not genomically altered. Chemotherapies and targeted agents with strong tumor-specific activities corroborated the siRNA profiling results and included drugs that targeted the mitotic spindle, the proteasome, and G&lt;sub&gt;2&lt;/sub&gt;–M kinases &lt;i&gt;WEE1&lt;/i&gt; and &lt;i&gt;CHK1&lt;/i&gt;. We also show the feasibility of &lt;i&gt;ex vivo&lt;/i&gt; drug profiling for patients enrolled in a clinical trial.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; High-throughput phenotyping with siRNA and drug libraries using patient-derived tumor cells prioritizes mutated driver genes and identifies novel drug targets not revealed by genomic profiling. Functional profiling is a promising adjunct to DNA sequencing for precision oncology. &lt;i&gt;Clin Cancer Res; 24(12); 2828–43. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Diversity of Fruit Quality Characteristics in Capsicum frutescens (2007)

Fruit of 40 genotypes of Capsicum frutescens L. from the US Department of Agriculture/Agricultural Research Service Capsicum germplasm collection were analyzed for a variety of fruit quality parameters, including fruit size, weight, and concentrations of capsaicinoids, sucrose, glucose, fructose, malic acid, and total acid equivalents. Fruit weight ranged from 0.23 g fresh weight to 4.04 g fresh weight (average 1.05g). Fruit length/width ranged from 1 to 8.0 (average, 3.61). Capsaicin concentrations ranged from 34 to 350 mg·100 g −1 fresh weight (average, 135 mg·100 g −1 fresh weight). Sucrose concentrations ranged from 0.28 to 1.0 g·100 g −1 (average, 0.6 g·100 g −1 fresh weight). Total sugar extracts ranged from 0.73% to 2.6% (average, 1.55%). Malic acid concentrations and total acid equivalents ranged from 0.62 to 2.29 g·100 g −1 fresh weight (average, 2.07 g·100 g −1 fresh weight) and 0.97 to 3.31 g·100 g −1 (average, 1.87 g·100 g −1 ) respectively. These data demonstrate an approximate 4 to 14-fold range in values for the characteristics examined, suggesting the presence of sufficient variability for these traits within this species to support the development of germplasm enhanced for specific or multiple fruit quality attributes.
Induction of acyl-coenzyme A:cholesterol acyltransferase-1 by 1,25-dihydroxyvitamin D3 or 9-cis-retinoic acid in undifferentiated THP-1 cells (2001)

We have previously shown that acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) protein content increases significantly during the human monocyte-macrophage differentiation process. To gain further insight, we used undifferentiated human monocytic THP-1 cells as a model system with which to examine whether ACAT-1 mRNA and protein content can be increased by treating cells with 1,25-dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)] or with 9-cis-retinoic acid (9-cis-RA), two agents known to upregulate the expression of various genes during the monocyte-macrophage differentiation process. Immunoblot analysis with anti-human ACAT-1 antibodies revealed that ACAT-1 protein was increased by 2.6-fold, using 1,25-(OH)(2)D(3) at a physiological concentration (100 pM). ACAT-1 protein was also increased when using 9-cis-RA, but only at relatively high concentrations (0.1;-1 microM). Northern blot analysis revealed that among the four ACAT-1 mRNA transcripts (2.8, 3.6, 4.2, and 7.0 kb) examined, only the 2.8- and 3.6-kb transcripts were selectively increased. On the basis of enzyme assays in vitro, ACAT activity was increased 3.0-fold by using 100 nM 1,25-(OH)(2)D(3), and 1.8-fold by using 1 microM 9-cis-RA. Together, our results suggest that 1,25-(OH)(3) participates in ACAT-1 gene expression during the monocyte-macrophage differentiation process.
Beamforming Designs Robust to Propagation Model Estimation Errors for Binaural Hearing Aids (2019)

This work introduces new binaural beamforming algorithms for hearing aids, with a good robustness to errors in the estimated target source propagation model. Two different binaural beamforming designs are proposed. One design is based on an adaptive null positioning scheme, and the second is based on a combination of the adaptive null positioning scheme and wider beampatterns. Simulations are performed using signals and propagation models obtained from multichannel binaural hearing aids recordings, including some in a mildly reverberant environment. Evaluations are done in terms of noise reduction and target distortion. Evaluation results illustrate the robustness of the two proposed designs to errors between the true and estimated directions of arrival for the target source, and to mismatch between the anechoic propagation models used for the beamformers designs and the reverberant propagation models used to generate the signals at the sensors or beamformer inputs. Both designs surpass the performance of standard binaural Minimum Variance Distortionless Response (MVDR) and binaural Generalized-Side Lobe Canceler (GSC) beamformers.
Hierarchical Control of Bridge-of-Bridge Multilevel Power Converters (2009)

Multilevel converters are among the members of the family of power-converter topologies for realizing higher power levels and better waveform quality. In addition to the established topologies of neutral-point-clamped three-level and cascaded H-bridge converters, novel topologies that offer attractive features, such as ease of modularity and functionality, continue to be introduced. Among these, the bridge-of-bridge multilevel converters have the potential for realizing multimegawatt systems with ease. This paper is aimed at presenting a systematic approach to developing their dynamic and steady-state models, leading to a hierarchical-control approach that is intuitive to realize and versatile in application. This paper presents the dynamic and steady-state models and computer simulations that demonstrate the approach in dc-1φ/ac and 3φ/ac- 3φ/ac power-conversion applications. An experimental validation of the models using a dc-1φ/ac asymmetrical-half-bridge converter is presented.
Photoassisted deposition of conducting palladium films (1991)

The authors have selectively deposited palladium on a wide variety of substrates including Kapton (polyimide resin), Ultem 1000 (polyetherimide resin), Teflon, silicon and silicon oxide. The palladium films were fabricated by ultraviolet photolytic decomposition of allylcyclopentadienyl palladium. The photolytic dissociation of this organometallic complex results in the formation of gaseous allyl (C3H5) and cyclopentadienyl (C5H5) species. These films are all conducting, but studies of the bulk resistivities suggest that thin films deposited on the polyimide resins are porous, and the resistivities deviate from the value expected for bulk palladium.
Fundamental tests of electrodynamic theories: Conceptual investigations of the Trouton-Noble and hidden momentum effects (2003)

In this paper we review certain controversial aspects of some experimental tests of electromagnetic forces and fields that imply unexpected and novel predictions of standard classical electrodynamics. Among the recent theoretical and experimental investigations in this field, we focus on a modified version of the Trouton-Noble experiment for which a non-null result is predicted. Another investigation deals with the correct expression of the force on a magnetic dipole that accounts for the harden momentum and thus, differs from the standard expression usually used in classical electrodynamics. The conceptual details of the experimental arrangements that can be used for the realization of these two tests are outlined.