gebhart/patrepeval huggingface dataset:
Evaluation of the Effect of 5 QT‐Positive Drugs on the JTpeak Interval — An Analysis of ECGs From the IQ‐CSRC Study (2019)

The JTpeak interval has been proposed as a new biomarker to demonstrate mixed ion channel effects, potentially leading to reduced late-stage electrocardiogram (ECG) monitoring for mildly QT-prolonging drugs. ECG waveforms from the IQ-CSRC study were used. Twenty healthy subjects were enrolled with 6 subjects on placebo and 9 subjects on each of 5 mildly QT-prolonging drugs - moxifloxacin, dofetilide, ondansetron, dolasetron, and quinine - and 1 negative drug, levocetirizine. A vector magnitude lead was derived from 12-lead ECGs, and measurements were made on a median beat from three 10-second replicates. Data were analyzed using a linear concentration-response model with QTcF and heart rate corrected JTpeak (JTpeak_c) as dependent variables. For moxifloxacin, dofetilide, and ondansetron, all pure hERG blockers, slopes of the concentration (C)-QTcF and C-JTpeak_c relationships were positive and statistically significant. With the prespecified linear model, the predicted effects on ΔΔQTcF and ΔΔJTpeak_c were 11.4 and 9.4 milliseconds for moxifloxacin at the geometric mean C<sub>max</sub> on day 1, 9.0 and 11.7 milliseconds for dofetilide and 11.5, and 7.9 milliseconds for ondansetron, respectively. In contrast, dolasetron and quinine, both with additional ion channel effects, prolonged QTcF with a positive C-ΔQTcF slope and predicted ΔΔQTcF effect on day 1 of 6.2 and 11.4 milliseconds, whereas the C-ΔJTpeak_c slope and the predicted ΔΔJTpeak on day 1 were negative (-0.3 and -7.5 milliseconds per ng/mL). Pure hERG-blocking drugs prolonged both the QTc and the JTpeak_c intervals, whereas drugs with mixed ion channel effects, including peak sodium inhibition, prolonged QTcF but not the JTpeak_c interval.
Effect of temperature on solid-state formation of bulk nanograined intermetallic Al3Ni during high-pressure torsion (2014)

A bulk form of nanograined intermetallic Al3Ni was produced by severe plastic deformation using high-pressure torsion (HPT). Powder mixtures of 75 mol% Al and 25 mol% Ni were processed by HPT at a selected temperature in the range of room temperature (RT) to 573 K under a pressure of 6 GPa. X-ray diffraction analysis revealed that the Al3Ni intermetallic formed after processing for 50 revolutions at RT but, as the processing temperature increased, less revolutions (i.e. lower imposed strain) were required for the formation of Al3Ni. Observations by transmission electron microscopy showed that the microstructure consists of ultrafine grains having a size of 300–2000 nm after 3 and 10 revolutions. Once the Al3Ni formed after a higher number of revolutions, equiaxed nanograins with a size of ~30 nm prevailed with a significant increase in hardness. The increase in hardness was more significant when processed at higher temperatures because of increasing the fraction of Al3Ni. It was shown that the solid-state formation of Al3Ni occurred due to enhanced diffusion (i.e. decreased activation energy for diffusion) through the presence of high density of lattice defects.
@INGate: a distributed intelligent network approach to bridge switching and packet networks (2002)

This paper presents the results of a joint project initiative, @INGate, in the area of computer/telephony network integration (CTNI) carried out by Siemens AG and the Technical University of Berlin. We propose a distributed intelligent network architecture (DINA) that implements a unified media communications service (UMCS) providing both messaging and telephony services along with network computing and service management throughout circuit switching and packet networks. The architecture comprises a series of interconnected and locally managed intelligent service nodes as interworking units (IWU) between heterogenous networks allowing the user access to a unified media store/bus (UMS/B) via traditional PSTN/ISDN/GSM equipment such as telephones, pagers and fax machines on the one hand and networked computers and PDAs equipped with mail readers and Web browsers on the other hand to enable both on-line and off-line communication. The core of this architecture is the network-bridge service node (NB-SN), a distributed intelligent network element (DINE) consisting of a channel matrix switch (CMS) and a data packet switch (DPS) to link to fixed/mobile telephony and data networks correspondingly, several resource platforms (RPs) connected to media conversion processors (MCPs) to perform media translation in required interchange formats, an Internet gateway (IG) for IP telephony and data access (including customer service control and agent-based network computing) holding the subscribers' mailboxes and providing the Internet connectivity, and a network-bridge service node controller (NB-SNC) to control the overall service logic and the above components. The NB-SN itself is managed along with other nodes in a distributed intelligent network (IN) by a TMN-compliant operation, administration and maintenance center (OAMC).
High-Speed Flex Chip-to-Chip Interconnect (2006)

Signaling rates up to 20 Gb/s on a flex-circuit chip-to-chip interconnect are reported in active testing based on 90-nm CMOS circuits. The characterization of two flex connector prototypes demonstrates their basic durability and good high-frequency performance
Coordinated Control ofFourWheelBraking andRearSteering (1992)

Inthis paper, weconsider acoordinated control of four-wheel independent braking andrearsteering. The objective ofthecontrol sytemistoimprove theoverall vehicle handling performance during combined braking aadturning maneuvers. Thebraking andsteeing inputsofthedriver areinterpreted asvehicle deceleration andyawrate commands, respectively. Thecontrol systemisdesigned using therobust servomechanism design methodology andisbased onaliearized vehicle dynmc model. Theobjective ofthecontroler istotrack thecommandeddeceleration andyawratebycoordinating the fourbrake torques andtherearsteerangle. Theeffectiveness ofthecontrol system iSevaluated bycomputer simulations using afull vehicle model. Simulation results showthat theintegrated braking andsteering control systemimproves thevehicle directional stability, path tracking, andperformance robustness toparameter variations anduncertainties.
Optimizing Memory Access in TCF Processors with Compute-Update Operations (2020)

The thick control flow (TCF) model is a data parallel abstraction of the thread model. It merges homogeneous threads (called fibers) flowing through the same control path to entities (called TCFs) with a single control flow and multiple data flows. Fibers of a TCF are executed synchronously with respect to each other and the number of them can be altered dynamically at runtime. Multiple TCFs can be executed in parallel to support control parallelism. In our previous work, we have outlined a special architecture, TPA (Thick control flow Processor Architecture), for executing TCF programs efficiently and shown that designing algorithms with the TCF model often leads to increased performance and simplified programs due to higher abstraction, eliminated loops and redundant program elements.Compute-update memory operations, such as multioperations and atomic instructions, are known to speed up parallel algorithms performing reductions and synchronizations. In this paper, we propose special compute-update memory operations for TCF processors to optimize iterative exclusive inter-fiber memory access patterns. Acceleration is achieved, e.g., in matrix addition and log-prefix style patterns in which multiple target locations can interchange data without reloads between the instructions that slows down execution. Our solution is based on modified active memory units and special memory operations that can send their reply value to another fiber than that initiating the access. We implement these operations in our TPA processor with a minimal HW cost and show that the expected speedups are achieved. Programming examples are given.
Human macroH2A1 drives nucleosome dephasing and genome instability in histone-humanized yeast (2023)

In addition to replicative histones, eukaryotic genomes encode a repertoire of non-replicative variant histones providing additional layers of structural and epigenetic regulation. Here, we systematically replaced individual replicative human histones with non-replicative human variant histones using a histone replacement system in yeast. Variants H2A.J, TsH2B, and H3.5 complemented for their respective replicative counterparts. However, macroH2A1 failed to complement and its expression was toxic in yeast, negatively interacting with native yeast histones and kinetochore genes. To isolate yeast with "macroH2A1 chromatin" we decoupled the effects of its macro and histone fold domains, which revealed that both domains sufficed to override native yeast nucleosome positioning. Furthermore, both modified constructs of macroH2A1 exhibited lower nucleosome occupancy that correlated with decreased short-range chromatin interactions (<20 Kb), disrupted centromeric clustering, and increased chromosome instability. While supporting viability, macroH2A1 dramatically alters chromatin organization in yeast, leading to genome instability and massive fitness defects.
Velocity-field characteristics of selectively doped GaAs/AlxGa1−xAs quantum-well heterostructures (1993)

Recent experimental observations indicating poor correlation between the saturation velocity and Ohmic mobility lead us to propose a theory for a velocity-limiting mechanism in quantum-well heterostructures. The theory is based on the distribution function which takes into account the electron-drift anisotropy introduced by the high electric field for a degenerately doped quantum well. The drift velocity is shown to be limited by the Fermi velocity; a result which indicates that the saturation velocity is independent of the low-field mobility which is strongly controlled by momentum-randomizing scattering events. The dominance of optical-phonon emission at high electric field lowers the saturation velocity below the Fermi velocity. Excellent agreement is obtained between the theoretical and experimental results on the velocity-field characteristics of GaAs/${\mathrm{Al}}_{\mathit{x}}$${\mathrm{Ga}}_{1\mathrm{\ensuremath{-}}\mathit{x}}$As quantum-well heterostructures.
Author Correction: Molecular engineering of safe and efficacious oral basal insulin (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
60 channel WDM transmitter using multiwavelength modelocked semiconductor laser (2002)

The simultaneous generation of 60 discrete wavelengths, with a 75 GHz interwavelength spacing, from a modelocked semiconductor diode laser is reported. The individual wavelengths are emitted as mutually synchronised 898 MHz return-to-zero pulse trains. Optical spectra and temporal diagnostics are provided.
Dry clutch control based on electromechanical actuator position feedback loop (2012)

The paper presents identification and control of an experimental dry clutch actuated by a geared dc motor and ball-ramp mechanism. The identification results are used to describe the multi-dimensional clutch friction coefficient characteristic. The proposed clutch torque control system is based on closed-loop actuator position control and the identified friction coefficient curves. In order to compensate for a clutch pack thermal expansion effect, which affects the torque control accuracy, the control strategy is extended with feedforward or feedback path that outputs a position reference additive signal. The torque control strategy is verified experimentally within a clutch slip speed control system.
EVALUATION OF CNN TEMPLATE ROBUSTNESS TOWARDS VLSI IMPLEMENTATION (1996)

In this paper a method for the evaluation of static robustness towards random variations in cellular neural network (CNN) templates is proposed. From this evaluation, circuit accuracy specifications for a VLSI implementation are derived which allow the designer to optimize the performance. Moreover, from this evaluation method, guidelines for robust template designs are derived and parametric testing templates are developed.
Sulforaphane-Mediated Reduction of Aflatoxin B-1-N-7-Guanine in Rat Liver DNA: Impacts of Strain and Sex (2011)

Aflatoxin B1 (AFB1) is a DNA-binding toxin that contributes to the burden of liver cancer in tropical areas. AFB1-DNA adducts are powerful biomarkers that discern individual and population risk from exposure to this carcinogen. The discovery of concordance between the metabolic pathways of the male Fischer rat and humans allowed data from rats to guide the development of chemoprevention strategies employed in clinical trials in high-risk regions. In this study, the variables of strain and sex are studied in the rat model, as a step toward understanding how ethnic differences and sex influence DNA adduct formation and the induction of enzymes by chemoprotective agents. Sulforaphane (SF), which induces phase II enzymes including glutathione S-transferases (GSTs), was evaluated for its ability to induce GST activity and reduce the AFB1-DNA adducts in livers of both sexes of two rat strains that differ in susceptibility to AFB1 hepatocarcinogenesis. A dose-dependent relationship was found for SF for both induction of GST and reduction in of AFB1-N7-guanine in both Fischer (sensitive to AFB1) and Sprague-Dawley rats (relatively resistant). Sprague-Dawley rats exhibited the greatest increase in GST levels and the largest reduction in AFB1-N7-guanine in liver DNA. Males and females of each strain were also compared to determine if the ability of SF to induce GST and reduce AFB1-N7-guanine correlated with gender differences in sensitivity to AFB1 carcinogenesis. No gender-specific responses to SF were observed. These results support the view that SF induction of liver GST activity may play a role in its chemoprotective activity.
Testing Reed–Muller Codes (2005)

A code is locally testable if there is a way to indicate with high probability that a vector is far enough from any codeword by accessing only a very small number of the vector's bits. We show that the Reed-Muller codes of constant order are locally testable. Specifically, we describe an efficient randomized algorithm to test if a given vector of length n=2/sup m/ is a word in the rth-order Reed-Muller code R(r,m) of length n=2/sup m/. For a given integer r/spl ges/1, and real /spl epsi/>0, the algorithm queries the input vector /spl upsi/ at O(1//spl epsi/+r2/sup 2r/) positions. On the one hand, if /spl upsi/ is at distance at least /spl epsi/n from the closest codeword, then the algorithm discovers it with probability at least 2/3. On the other hand, if /spl upsi/ is a codeword, then it always passes the test. Our result is almost tight: any algorithm for testing R(r,m) must perform /spl Omega/(1//spl epsi/+2/sup r/) queries.
Application of the Kramers–Kronig Relations to Multi-Sine Electrochemical Impedance Measurements (2020)

Impedance spectra obtained by fast Fourier transformation of the response to a multi-sine potential perturbation are shown to be consistent with the Kramers–Kronig relations, even for systems that are nonlinear and nonstationary. These results, observed for measurements on a Li/SOCl 2 battery, were confirmed by numerical simulations. Consistency with the Kramers–Kronig relations was confirmed by use of the measurement model developed by Agrawal et al. and by a linear measurement model approach developed by Boukamp and implemented by Gamry. The present work demonstrates that application of the Kramers–Kronig relations to the results of multi-sine measurements cannot be used to determine whether the experimental system satisfies the conditions of linearity, causality and stability.
The assessment of the relationship between performance audits on public accountability in Iran (2012)

The purpose of this research is the assessment of the relationship between performance audits accountability on the point of view of Supreme Audit Court's auditors. In this research, the statistical society includes 1072 individuals taken from Audit Court Supreme's official technical experts. In the present study, 330 individuals have been chosen as sample through random sampling. T-test and Freidman Correlation test are used for analyzing data. The results show a confirmation of a direct relationship between audit performances on public accountability. Moreover, the use of performance audit leads to an increase in clarity, quality and the qualitative characteristics of information and finally to an upgrade in accountability of the government in its actions' performance. Keywords: performance audit; accountability; Iran's Supreme Audit Court; clarity.
Comparison of Diameter and Perimeter Methods for Tumor Volume Calculation (2001)

Variability of measurements was reduced with the computer-assisted perimeter method compared with the diameter method, which suggests that changes in volume can be detected more accurately with the perimeter method. The differences between these techniques seem large enough to have an impact on grading the response to therapy.
ChemInform Abstract: K2Mn(VO3)4, a New Three‐Dimensional Potassium Manganese(II) Polyvanadate. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Model-based OPC for 0.13-μm contacts using 248-nm Att PSM (2002)

Controlling errors of critical dimension (CD) uniformity is crucial to achieving optimal IC performance, high chip yield and long lasting reliability. When the CDs to be resolved are less than the wavelength equipped by a lithographic exposure tool, the chip level CD variations caused by optical proximity effect (OPE) have been found significantly. With the relentlessly reduced CDs in integrated circuits the impact of OPE to chip yield and performance is much more profound and necessitates an inverse correction. In this paper, we report a model-based full-chip OPC on the contact hole layer of 0.13-micrometers logic circuits using 248-nm photo processing and attenuated phase-shifting mask (Att PSM). The final result demonstrates that OPE of random logic contact hole level can be greatly surpassed and controlled even with mask errors and their enhancement factors included of which are typically quite significant with layers of contact holes.
Anthropogenic CO2 Properties (2012)

This chapter highlights and explores compositional quality scenarios of anthropogenic CO2 for the different capture technologies and pipeline transportation. Anthropogenic CO2 originates largely from power plants which employ the post-combustion, pre-combustion and oxyfuel capture technologies. The levels of impurities present are driven by the economic, environmental and safety considerations for both capture technology and pipeline transportation. While this chapter highlights both globally, Chapter 5 details pipeline related issues with respect to impact of impurities on pipeline design and specifications.
ChemInform Abstract: Synthesis of Novel Isoxazolinyl Substituted Imidazo[1,2‐a]pyridine C‐Nucleoside Analogues. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Trends in radical prostatectomy (2008)

The surgical treatment of prostate cancer ideally removes the entire cancer, avoids excessive blood loss or serious perioperative complications, and results in complete recovery of continence and potency. To achieve this, the surgeon must excise sufficient periprostatic tissue to cure the cancer while preserving the cavernosal nerves required for erectile function and the neuromusculature required for normal urinary and bowel function. Here we will examine recent trends in radical prostatectomy, focusing on surgical technique.
Multipotent Stem Cells in the Adult Central Nervous System (2001)

A stem cell is an undifferentiated cell capable of extensive proliferation that can give rise to more stem cells (self-renewal) as well as to a progeny that will terminally differentiate and integrate into the tissue of residence, to replace cells lost to physiological turnover or injury. These features make stem cells an essential element both in the embryonic development and in the maintenance of adult tissue cell renewal. For example, a constant number of terminally differentiated cells in tissues and organs like the intestinal crypts, the skin, and blood are maintained through stem cell activity throughout life. However, not all tissues are endowed with physiologic continuous cell renewal, and, when this is the case, they display this property at very different rates. In this context, the mature nervous tissue has long been considered incapable of cell renewal and structural remodeling, especially in mammals. Studies carried out in the last decades have uncovered unexpected potential concerning the existence and extent of postnatal and adult neurogenesis in the mammalian central nervous system (CNS). As a consequence, questions have been raised regarding the existence and location of true stem cells in the CNS, which may be able to sustain adult neurogenesis continuously and may even provide an endogenous source of new neural cells in the course of reparative processes.
Synthesis and Structure of a Trigonal Monopyramidal Vanadium(III) Complex, [(C6F5NCH2CH2)3N]V, and the Vanadium(IV) Product of Its Oxidation, {[(C6F5NCH2CH2)2N(CH2CH2NHC6F5)]V(O)}2 (1997)

Reduction of [N3NF]VCl ([N3NF]3- = [(C6F5NCH2CH2)3N]3-) with sodium amalgam in toluene yields dark green, trigonal monpyramidal, paramagnetic [N3NF]V (1). During attempts to recrystallize 1 from toluene at room temperature, bright green crystals of {[(C6F5NCH2CH2)2N(CH2CH2NHC6F5)]V(O)}2 (2) formed over a period of 2 weeks, possibly from traces of water. A key feature of 2 is that one arm of the triamidoamine ligand has been protonated and is now “dangling” away from the metal.
Graph matching problems for annotating C. Elegans (2017)

Graph matching problems as described in "Active Graph Matching for Automatic Joint Segmentation and Annotation of C. Elegans." by Kainmueller, Dagmar and Jug, Florian and Rother, Carsten and Myers, Gene, MICCAI 2014. Problems are in OpenGM2 hdf5 format (see http://hciweb2.iwr.uni-heidelberg.de/opengm/) and a custom text format used by the feature matching solver described in "Feature Correspondence via Graph Matching: Models and Global Optimization." by Lorenzo Torresani, Vladimir Kolmogorov and Carsten Rother, ECCV 2008, code at http://pub.ist.ac.at/~vnk/software/GraphMatching-v1.02.src.zip.
Learning ontologies to improve the quality of automatic web service matching (2007)

This paper presents a novel technique that significantly improves the quality of semantic Web service matching by (1) automatically generating ontologies based on Web service descriptions and (2) using these ontologies to guide the mapping between Web services.
Monomorphic post-transplant lymphoproliferative disorder of the tongue: case report and review of literature (2007)

This rare case increased our awareness of PTLD in the oral cavity of patients following solid organ transplantation and immunosuppressive therapy.
Chemical and Electrochemical Corrosion Behavior of Ti3SiC2, Ti3GeC2 and Ti in Common Acids and NaOH (2006)

Abstract not Available.