gebhart/patrepeval huggingface dataset:
Synthesis and Fundamental Properties of Stable Ph3SnSiH3 and Ph3SnGeH3 Hydrides: Model Compounds for the Design of Si−Ge−Sn Photonic Alloys (2009)

The compounds Ph(3)SnSiH(3) and Ph(3)SnGeH(3) (Ph = C(6)H(5)) have been synthesized as colorless solids containing Sn-MH(3) (M = Si, Ge) moieties that are stable in air despite the presence of multiple and highly reactive Si-H and Ge-H bonds. These molecules are of interest since they represent potential model compounds for the design of new classes of IR semiconductors in the Si-Ge-Sn system. Their unexpected stability and high solubility also makes them a safe, convenient, and potentially useful delivery source of -SiH(3) and -GeH(3) ligands in molecular synthesis. The structure and composition of both compounds has been determined by chemical analysis and a range of spectroscopic methods including multinuclear NMR. Single crystal X-ray structures were determined and indicated that both compounds condense in a Z = 2 triclinic (P1) space group with lattice parameters (a = 9.7754(4) A, b = 9.8008(4) A, c = 10.4093(5) A, alpha = 73.35(10)(o), beta = 65.39(10)(o), gamma = 73.18(10)(o)) for Ph(3)SnSiH(3) and (a = 9.7927(2) A, b = 9.8005(2) A, c = 10.4224(2) A, alpha = 74.01(3)(o), beta = 65.48(3)(o), gamma = 73.43(3)(o)) for Ph(3)SnGeH(3). First principles density functional theory simulations are used to corroborate the molecular structures of Ph(3)SnSiH(3) and Ph(3)SnGeH(3), gain valuable insight into the relative stability of the two compounds, and provide correlations between the Si-Sn and Ge-Sn bonds in the molecules and those in tetrahedral Si-Ge-Sn solids.
Synthesis, Crystal Structure, and DFT Study of a New Derivative of Pyrido[2,3-d]pyrimidine (2021)

N-{4-[(6-bromopyrido[2,3-d]pyrimidin-4-yl)oxy]phenyl}morpholine-4-carboxamide has been synthesized as a derivative of pyrido[2,3-d]pyrimidine that demonstrates antitumor, antibacterial, anti-inflammatory, and antimicrobial activities. Synthesis of the target compound based on 2-aminonicotinic acid as the starting material has included its esterification, bromination, cyclization, and substitution reactions. Structure of the product is confirmed by 1H and 13C NMR, FT-IR, and single-crystal X-ray diffraction (XRD). The optimized structure, electrostatic potential and frontier molecular orbitals (FMO) of the compound have been approached by DFT calculations. The compound demonstrates antiproliferative activity on A375 cells.
ChemInform Abstract: Asymmetric Robinson Anellation Using Catalytic Amounts of a Rigid Bicyclic α‐Amino Acid. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Capacity Upper Bound for Adding Cells in the Super Dense Cellular Deployment Scenario (2014)

In this paper, we investigate a super dense cellular deployment case in which the cells are continuously added in order to increase the total network capacity. The effect of the other cell interference in the HSPA network is analyzed, which provides an insight into the aggregated interference impact on the cell capacity. The network capacity performance with varying cell densities has been studied with system-level simulations. The results show that there is an upper bound existing for the total HSDPA downlink capacity when continuously adding cells within an open area. This paper can serve as essential guidelines both for macro cell densification and small cell deployment. It is recommended that careful considerations need to be taken if an operator intends to improve network performance by adding cells to their networks in dense urban cities.
Clinical Genetic Risk Variants Inform a Functional Protein Interaction Network for Tetralogy of Fallot (2021)

The results are relevant to precision medicine for TOF. They suggest considerable clinical yield from genome-wide sequencing, with further evidence for <i>KDR</i> (VEGFR2) as a congenital heart disease/TOF gene and for VEGF (vascular endothelial growth factor) and Notch signaling as mechanisms in human disease. Harnessing the genetic heterogeneity of single gene defects could inform etiopathogenesis and help prioritize novel candidate genes for TOF.
Multiview Canonical Correlation Analysis over Graphs (2019)

Multiview canonical correlation analysis (MCCA) looks for shared low-dimensional representations hidden in multiple transformations of common source signals. Existing MCCA approaches do not exploit the geometry of common sources, which can be either given a priori, or constructed from do- main knowledge. In this paper, a novel graph-regularized (G) MCCA is developed to account for such geometry-bearing in- formation via graph regularization in the classical maximum- variance MCCA model. GMCCA minimizes the distance between the sought canonical variables and the common sources, while incorporating the graph-induced prior of these sources. To capture nonlinear dependencies, GMCCA is fur- ther broadened to the graph-regularized kernel (GK) MCCA. Numerical tests using real datasets document the merits of G(K)MCCA in comparison with competing alternatives.
Time-Resolved XUV Absorption Spectroscopy and Magnetic Circular Dichroism at the Ni M2,3-Edges (2020)

Ultrashort optical pulses can trigger a variety of non-equilibrium processes in magnetic thin films affecting electrons and spins on femtosecond timescales. In order to probe the charge and magnetic degrees of freedom simultaneously, we developed an X-ray streaking technique that has the advantage of providing a jitter-free picture of absorption cross-section changes. In this paper, we present an experiment based on this approach, which we performed using five photon probing energies at the Ni M2,3-edges. This allowed us to retrieve the absorption and magnetic circular dichroism time traces, yielding detailed information on transient modifications of electron and spin populations close to the Fermi level. Our findings suggest that the observed absorption and magnetic circular dichroism dynamics both depend on the extreme ultraviolet (XUV) probing wavelength, and can be described, at least qualitatively, by assuming ultrafast energy shifts of the electronic and magnetic elemental absorption resonances, as reported in recent work. However, our analysis also hints at more complex changes, highlighting the need for further experimental and theoretical studies in order to gain a thorough understanding of the interplay of electronic and spin degrees of freedom in optically excited magnetic thin films.
Distributed net-centric architecture of m2m acquisition units with optical GVA (2005)

This paper describes the architecture of a low-latency symmetric multiprocessing optical soft memory system to cluster computing inside the core of an adaptive optical signal processor with the aid of soft decision algebraic polynomial algorithms. The optical system hardware is shown to evolve along with the iterator instantiations of the soft algorithm that forms the core of the memory map. The system enables efficient cache coherence protocols used in unit multiprocessors to be run across a homogeneous cluster in optical soft memory systems. We define a structure called the Optical Generalized Viterbi Algorithm Data Structure (Optical GVA DS) that makes up the system map for adaptive optical signal processing. The system executes transforms where algorithms for handling the entire data vector is processed, shortening the computational complexity effectively. Thus the optical soft memory system as described by the evolving Optical GVA DS iterator instantiates enables the design of parallel processors to handle modulated data in the optical domain. This is of importance in the realization of distributed netcentric architectures and forms the basis of large-scale real-time data processing and acquisition in m2m units.
Performance enhancement through optimal n-tier multilevel interconnect architectures (2003)

A stochastic wire-length distribution is used to develop an optimal n-tier multilevel interconnect architecture for a 0.1 /spl mu/m ASIC macrocell. The results of the n-tier design when compared to the 2-tier design show a 30% reduction of metal levels, three fold reduction in macrocell area or three fold increase in clock frequency.
Passively Q-switched microchip lasers and applications (2004)

Passively Q-switched microchip lasers are compact, robust, high-performance devices that produce subnanosecond, multikilowatt optical pulses. They are enabling new classes of fieldable instruments to perform ranging and imaging, micromachining, material characterization, and environmental monitoring.
Study on wide area measurement system based transient stability control for power system (2005)

In this paper, the state of the arts of power systems in China and some applications in transient stability control based on wide area measurement system (WAMS) are introduced briefly. With the development of power grid interconnection and transmission utility deregulation, the operation of electric power system become more and more complex, which challenges the security and transient stability control of power systems. The advent of WAMS opens a new path to the system trajectory prediction and real time closed-loop stability control to prevent power system outage. The defects of current transient stability control system are analyzed, then a possible scheme of transient stability control based on WAMS is proposed, and the corresponding future work is put forward as well. Finally, a new way of solving cascading events is discussed.
Synthesis and Structural Characterization of Nickel Complexes Possessing P-Stereogenic Pincer Scaffolds and Their Application in Asymmetric Aza-Michael Reactions (2015)

Novel P-stereogenic pincer-Ni complexes {κP,κC,κP-3,5-Me2-2,6-(MetBuPCH2)2C6H}NiCl (3), {κP,κC,κP-3,5-Me2-2,6-(MetBuPCH2)2C6H}NiOTf (4), [{κP,κN,κP-2,6-(MetBuPCH2)2C5H3N}NiCl]Cl (7), [{κP,κN,κP-2,6-(MetBuPCH2)2C5H3N}NiCl]BF4 (8), and [{κP,κN,κP-2,6-(MetBuPCH2)2C5H3N}Ni(NCMe)](BF4)2 (9) were synthesized in 55–84% yields and characterized by 1H NMR, 13C{1H} NMR, 31P{1H} NMR, 19F{1H} NMR, and/or single-crystal X-ray diffractions. The ORTEP diagrams of complexes 3, 7, 8, and 9 show that the coordination geometries around the Ni center in all these structures are approximately square planar but have different bond lengths and angles. These complexes were shown to be active catalysts for the asymmetric aza-Michael addition of α,β-unsaturated nitriles. For most examples good to excellent yields (up to 99%) and moderate enantiomeric excesses (up to 46% ee) were obtained. Notably, the PCP complex 3 exhibited higher catalytic activity in the aza-Michael addition than the PNP complexes 7, 8, and 9. Two achiral PCP-type pincer-Ni complexes, {κP,κC,κP-3,5-Me2-2,6-(tBu2PCH2)2C6H}NiCl (11) and {κP,κC,κP-3,5-Me2-2,6-(Ph2PCH2)2C6H}NiCl (13), were also synthesized and fully characterized in order to reveal the structural differences between the chiral and achiral complexes.
Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells (2016)

The genetic integrity of each organism is intimately tied to the correct segregation of its genome during mitosis. Insights into the underlying mechanisms are fundamental for both basic research and the development of novel strategies to treat mitosis-relevant diseases such as cancer. Due to their fast mode of action, small molecules are invaluable tools to dissect mitosis. Yet, there is a great demand for novel antimitotic compounds. We performed a chemical genetic suppression screen to identify compounds that restore spindle bipolarity in cells treated with Monastrol, an inhibitor of the mitotic kinesin Eg5. We identified one compound-MAC1-that rescued spindle bipolarity in cells lacking Eg5 activity. Mechanistically, MAC1 induces the formation of additional microtubule nucleation centers, which allows kinesin Kif15-dependent bipolar spindle assembly in the absence of Eg5 activity. Thus, our chemical genetic suppression screen revealed novel unexpected insights into the mechanism of spindle assembly in mammalian cells.
Tunability of intersubband absorption from 4.5 to 5.3 μm in a GaN/Al0.2Ga0.8N superlattices grown by metalorganic chemical vapor deposition (2009)

Intersubband (ISB) absorption at wavelengths as long as 5.3 μm is realized in GaN/Al0.2Ga0.8N superlattices grown by metalorganic chemical vapor deposition. By employing low aluminum content Al0.2Ga0.8N barriers and varying the well width from 2.6 to 5.1 nm, ISB absorption has been tuned from 4.5 to 5.3 μm. Theoretical ISB absorption and interband emission models are developed and compared to the experimental results. The effects of band offsets and the piezoelectric fields on these superlattices are investigated.
Highly compact fiber optic gyrocompass for applications at depths up to 3000 meters (2002)

Octans is a fiber-optic gyrocompass with an integral motion sensor developed by Photonetics for demanding marine applications. In contrast with conventional gyrocompasses relying on a spinning gyroscope, Octans has no moving parts and utilizes instead three fiber optic gyroscopes (FOG) and three quartz accelerometers. The FOG technology is based on the relativistic Sagnac effect: light travels in opposite directions into a fiber optic coil, and interferes at the output with a phase-shift proportional to the rotation rate. Moreover, three accelerometers measure, after Schuler filtering, the local gravity vector. As the FOGs are enough accurate (typically a bias stability of 0,05 /spl deg//h), the observation of the gravity slow drift in the inertial space allows one to determine the Earth axis, thus the North direction. In addition, the real three-axis architecture allows Octans to act as a marine motion sensor and compute the complete attitude of the vessel in terms of roll, pitch, heave, surge and sway. Because of a specific algorithm, Octans is able to find the true heading without any help in three minutes even at sea. This system is obviously ideal for ROVs and AUVs applications: low power consumption, compact, light box and very low settling time.
Inhibitors of glutamate transport modulate distinct patterns in brain metabolism (2006)

High affinity uptake of glutamate plays a major role in the termination of excitatory neurotransmission. Identification of the ramifications of transporter function is essential to understand the diseases in which defective excitatory amino acid transporters (EAAT) have been implicated. In this work we incubated Guinea pig cortical tissue slices with [3-(13)C]pyruvate and major currently available glutamate uptake inhibitors and studied the resultant metabolic sequelae by (13)C and (1)H NMR spectroscopy using a multivariate statistical approach. Perturbation of glutamate uptake produced significant effects on metabolic flux through the Krebs cycle, and on glutamate/glutamine cycling rates, with this effect accounting for 76% of the variation in the total data set. The effects of all inhibitors were separable from each other along three major principal components. The competitive inhibitor L-CCG III ((2S,1'S,2'R)-2-carboxycyclopropyl)glycine) differed most from the other inhibitors, showing negative weightings on both the first and second principal components, whereas the EAAT2-specific inhibitor dihydrokainate (DHK) showed metabolic patterns similar to that of anti-endo-3,4-methanopyrolidine dicarboxylate but separate from those of DL-threo-beta-benzyloxyaspartate (TBOA) and L-trans-pyrrolidine-2,4-dicarboxylate (L-tPDC). This indicates that different inhibition mechanisms or different colocalisation of the separate transporter subtypes with glutamate receptors can produce significantly different metabolic and functional outcomes for the brain.
Cloning, recombinant expression and biochemical characterization of the murine CD83 molecule which is specifically upregulated during dendritic cell maturation (1999)

Human CD83 (hCD83) is a glycoprotein expressed predominantly on the surface of dendritic cells (DC) and represents the best marker for mature DC. Here, we report the cloning of the cDNA encoding mouse CD83 (mCD83) from a murine bone marrow-derived DC (BM-DC) cDNA library. DNA sequence analysis revealed a 196 amino acid protein including a signal peptide of 21 amino acids which shares 63% amino acid identity with hCD83. Using Northern blot analyses, mCD83 mRNA was found to be strongly expressed in mouse BM-DC and its expression was upregulated following stimulation with LPS or TNF-alpha. Transfection experiments using COS-7 cells revealed that mCD83 is glycosylated. Furthermore, the extracellular CD83 domain was recombinantly expressed in Escherichia coli and one-dimensional NMR data strongly support that the protein is structurally folded.
Parameter insensitive passive lossless current sharing method based on negative current (2010)

A parameter insensitive passive lossless current sharing method that minimizes conduction losses is introduced. Using only the information about the polarity of inductor current an optimal current sharing is achieved. The accurate knowledge of the converter component values is not required and the practical implementation is well-suited for on-chip integration. The effectiveness of the new system is demonstrated with a 12V-to-1.5V/70 W, 500 kHz dual-phase interleaved buck converter demonstrating about 1.7% improvement in efficiency compared to no current sharing.
Isoniazid: A Review of Characteristics, Properties and Analytical Methods (2017)

Isoniazid is a synthetic antimicrobial and one of the most important first-line drugs used in the treatment of tuberculosis. Since it was introduced in the therapy in 1952, the drug remains at the front line of the antituberculosis treatment mainly due to its potency and high selectivity against Mycobacterium tuberculosis. Pharmaceutical analysis and therapeutic drug monitoring of isoniazid in both, pharmaceuticals and biological samples, plays an important role to comprehend aspects regarding to bioavailability, bioequivalence and therapeutic monitoring during patients following-up. In the last case, validated and simple methods are extremely useful for Public Healthy in order to guarantee the drug efficacy, safety and reduce the tuberculosis resistance. Among the available analytical tools, HPLC-based methods coupled to ultraviolet or mass spectroscopy are the most widely used techniques to quantify isoniazid. Therefore, this review highlights the main analytical methods reported in the literature for determination of isoniazid focusing in HPLC-based methods.
Fatty Acid Based Biodegradable Polymer (2008)

Synthetic polymers have become an indispensable part of the daily‐life of human beings and the biodegradable class of polymers hold immense value in therapeutics. Fatty acid incorporation in biodegradable polymers renders flexibility, low melting point, hydrophobicity, and pliability properties. At the same time, degradation into naturally occurring compounds makes them environmentally friendly besides their utility in various applications like drug delivery and as implantable devices. Fatty acid monomers are integrated in the polymeric chain using carboxylic acid functional groups. Most fatty acids are monofunctional in nature and act only as chain terminator during polymerization. This limitation has been overcome by the dimerization of unsaturated fatty acids or by creating a functional group on the monomers. The most recent addition to this series is ricinoleic acid based polyanhydrides and copolyesters. In this article, the synthesis methods, the physical properties, the degradation, the stability, and the toxicological aspect and applications of each class of fatty acid based polymers are discussed. Keywords: biodegradable polymerfatty acidsynthesisdegradationbiocompatibilitystabilitybiomedical application
A 0.1e- vertical FPN 4.7e- read noise 71dB DR CMOS image sensor with 13b column-parallel single-ended cyclic ADCs (2009)

The performance requirements of next-generation CMOS image sensors (CIS) have been increasing in terms of frame rate, read noise, dynamic range, as well as pixel resolution. In order to satisfy strict specifications, a column-parallel ADC is a key element in a state-of-the-art CIS. However, this architecture leads to side-effects such as vertical fixed pattern noise (VFPN) and read noise. In order to reduce these non-idealities, several techniques can be applied such as digital CDS using a single-slope ADC, and pre-amplified digital CDS using a SAR ADC. It is challenging to overcome the difficulty of compatibility between ADC speed and bit resolution, while maintaining low-noise performance and high dynamic range (DR). In this paper, a low-noise high-DR and high-speed CIS with a 13b column-parallel cyclic ADC based on a single-ended architecture is presented. The cyclic ADC requires 12 cycles for 13b resolution. The ADC requires identical conversions for reset and signals, within the limited horizontal time period, at a frame rate of over 300 fps, so as to achieve perfect digital CDS and ultra-low VFPN. In addition, lower total read noise is achieved without signal amplification by removing: (1) dual analog paths in fully differential circuits, (2) a common reference route, and (3) digital coupling noise. Published cyclic ADCs that are located in the column of a CIS have column pitch of 15 mum or larger. The circuits with the single-ended architecture presented in this paper are squeezed into 5.6 mum column pitch and can be applied to 2.8 mum-pitch pixels with double-side disposition.
Tailoring the Work Function of Gold Surface by Controlling Coverage and Disorder of Polar Molecular Monolayers (2008)

We show here that the work function of Au can be controlled not only by the magnitude and direction of adsorbed polar molecules but also by the molecular coverage and (dis)order within the molecular patterns. Molecular monolayers composed of two types of molecules with opposite dipoles were deposited on Au films containing the changes of the work function due to variation of molecular coverage and disorder were monitored. The results indicate that the requirements on molecular layers covering Au surfaces are significantly relaxed and that partial, disordered monolayers can be used to tailor the work function of metal surfaces.
Creep Resistance of S304H Austenitic Steel Processed by High-Pressure Sliding (2022)

Sheets of coarse-grained S304H austenitic steel were processed by high-pressure sliding (HPS) at room temperature and a ultrafine-grained microstructure with a mean grain size of about 0.14 µm was prepared. The microstructure changes and creep behavior of coarse-grained and HPS-processed steel were investigated at 500-700 °C under the application of different loads. It was found that the processing of S304H steel led to a significant improvement in creep strength at 500 °C. However, a further increase in creep temperature to 600 °C and 700 °C led to the deterioration of creep behavior of HPS-processed steel. The microstructure results suggest that the creep behavior of HPS-processed steel is associated with the thermal stability of the SPD-processed microstructure. The recrystallization, grain growth, the coarsening of precipitates led to a reduction in creep strength of the HPS-processed state. It was also observed that in the HPS-processed microstructure the fast formation of σ-phase occurs. The σ-phase was already formed during slight grain coarsening at 600 °C and its formation was enhanced after recrystallization at 700 °C.