gebhart/patrepeval huggingface dataset:
A convergent general synthetic protocol for construction of spirocyclic ketal ionophores: an application to the total synthesis of (-)-A-23187 (calcimycin) (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA convergent general synthetic protocol for construction of spirocyclic ketal ionophores: an application to the total synthesis of (-)-A-23187 (calcimycin)Robert K. Boeckman Jr., Andre B. Charette, Theodros Asberom, and Brian H. JohnstonCite this: J. Am. Chem. Soc. 1987, 109, 24, 7553–7555Publication Date (Print):November 1, 1987Publication History Published online1 May 2002Published inissue 1 November 1987https://pubs.acs.org/doi/10.1021/ja00258a063https://doi.org/10.1021/ja00258a063research-articleACS PublicationsRequest reuse permissionsArticle Views900Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ChemInform Abstract: What′s New in Olefin Metathesis Catalyzed by Molybdenum and Tungsten Complexes? (2011)

Abstract Review: 31 refs.
Current Harmonics Cancellation in Three-Phase Four-Wire Systems by Using a Four-Branch Star Filtering Topology (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper presents a new solution for filtering current harmonics in three-phase four-wire networks. The original four-branch star (FBS) filter topology presented in this paper is characterized by a particular layout of single-phase inductances and capacitors, without using any transformer or special electromagnetic device. Via this layout, a power filter, with two different and simultaneous resonance frequencies and sequences, is achieved—one frequency for positive-/negative-sequence and another one for zero-sequence components. This filter topology can work either as a passive filter, when only passive components are employed, or as a hybrid filter, when its behavior is improved by integrating a power converter into the filter structure. The paper analyzes the proposed topology, and derives fundamental concepts about the control of the resulting hybrid power filter. From this analysis, a specific implementation of a three-phase four-wire hybrid power filter is presented as an illustrative application of the filtering topology. An extensive evaluation using simulation and experimental results from a DSP-based laboratory prototype is conducted in order to verify and validate the good performance achieved by the proposed FBS passive/hybrid power filter. </para>
ChemInform Abstract: METALATION OF 2,2‐DIMETHYL‐5‐METHYLENE‐1,3‐DIOXANE. A FUNCTIONALIZED ALLYLOXY CARBANION (1979)

Abstract Das in bekannter Weise zugängliche Dioxan (I) reagiert mit Butyllithium zu einem Anion, das mit Alkylierungsmitteln (II) zu Mischungen aus den isomeren Substitutionsprodukten (III) und (IV) umgesetzt wird.
ChemInform Abstract: A Facile Preparation of Benzyltrimethylstannanes and Their Utility in the Synthesis of 1‐Benzyl‐1,2‐dihydroisoquinolines. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Impact of SMART Pass filter in patients with ajmaline-induced Brugada syndrome and subcutaneous implantable cardioverter-defibrillator eligibility failure: results from a prospective multicentre study (2021)

https://clinicaltrials.gov Unique Identifier NCT04504591.
Segmentation of the Optic Disc in 3-D OCT Scans of the Optic Nerve Head (2009)

Glaucoma is the second leading ocular disease causing blindness due to gradual damage to the optic nerve and resultant visual field loss. Segmentations of the optic disc cup and neuroretinal rim can provide important parameters for detecting and tracking this disease. The purpose of this study is to describe and evaluate a method that can automatically segment the optic disc cup and rim in spectral-domain 3-D OCT (SD-OCT) volumes. Four intraretinal surfaces were segmented using a fast multiscale 3-D graph search algorithm. After surface segmentation, the retina in each 3-D OCT scan was flattened to ensure a consistent optic nerve head shape. A set of 15 features, derived from the segmented intraretinal surfaces and voxel intensities in the SD-OCT volume, were used to train a classifier that can determine which A-scans in the OCT volume belong to the background, optic disc cup and rim. Finally, prior knowledge about the shapes of the cup and rim was incorporated into the system using a convex hull-based approach. Two glaucoma experts annotated the cup and rim area using planimetry, and the annotations of the first expert were used as the reference standard. A leave-one-subject-out experiment on 27 optic nerve head-centered OCT volumes (14 right eye scans and 13 left eye scans from 14 patients) was performed. Two different types of classification methods were compared, and experimental results showed that the best performing method had an unsigned error for the optic disc cup of 2.52+/-0.87 pixels (0.076+/-0.026 mm) and for the neuroretinal rim of 2.04+/-0.86 pixels (0.061+/-0.026 mm). The interobserver variability as indicated by the unsigned border positioning difference between the second expert observer and the reference standard was 2.54+/-1.03 pixels (0.076+/-0.031 mm for the optic disc cup and 2.14+/-0.80 pixels (0.064+/-0.024 mm for the neuroretinal rim. The unsigned error of the best performing method was not significantly different (p > 0.2) from the interobserver variability.
Feasibility of corifollitropin alfa/GnRH antagonist protocol combined with GnRH agonist triggering and freeze-all strategy in polycystic ovary syndrome patients (2017)

The results suggest that corifollitropin alfa/GnRH antagonist protocol can be used in PCOS patients, in combination with GnRHa triggering and embryo cryopreservation.
Texture descriptors to distinguish radiation necrosis from recurrent brain tumors on multi-parametric MRI (2014)

Differentiating radiation necrosis (a radiation induced treatment effect) from recurrent brain tumors (rBT) is currently one of the most clinically challenging problems in care and management of brain tumor (BT) patients. Both radiation necrosis (RN), and rBT exhibit similar morphological appearance on standard MRI making non-invasive diagnosis extremely challenging for clinicians, with surgical intervention being the only course for obtaining definitive "ground truth". Recent studies have reported that the underlying biological pathways defining RN and rBT are fundamentally different. This strongly suggests that there might be phenotypic differences and hence cues on multi-parametric MRI, that can distinguish between the two pathologies. One challenge is that these differences, if they exist, might be too subtle to distinguish by the human observer. In this work, we explore the utility of computer extracted texture descriptors on multi-parametric MRI (MP-MRI) to provide alternate representations of MRI that may be capable of accentuating subtle micro-architectural differences between RN and rBT for primary and metastatic (MET) BT patients. We further explore the utility of texture descriptors in identifying the MRI protocol (from amongst T1-w, T2-w and FLAIR) that best distinguishes RN and rBT across two independent cohorts of primary and MET patients. A set of 119 texture descriptors (co-occurrence matrix homogeneity, neighboring gray-level dependence matrix, multi-scale Gaussian derivatives, Law features, and histogram of gradient orientations (HoG)) for modeling different macro and micro-scale morphologic changes within the treated lesion area for each MRI protocol were extracted. Principal component analysis based variable importance projection (PCA-VIP), a feature selection method previously developed in our group, was employed to identify the importance of every texture descriptor in distinguishing RN and rBT on MP-MRI. PCA-VIP employs regression analysis to provide an importance score to each feature based on their ability to distinguish the two classes (RN/rBT). The top performing features identified via PCA-VIP were employed within a random-forest classifier to differentiate RN from rBT across two cohorts of 20 primary and 22 MET patients. Our results revealed that, (a) HoG features at different orientations were the most important image features for both cohorts, suggesting inherent orientation differences between RN, and rBT, (b) inverse difference moment (capturing local intensity homogeneity), and Laws features (capturing local edges and gradients) were identified as important for both cohorts, and (c) Gd-C T1-w MRI was identified, across the two cohorts, as the best MRI protocol in distinguishing RN/rBT.
Unexpected Cardiac MRI Findings in Patients Presenting to the Emergency Department for Possible Acute Coronary Syndrome (2018)

This experience suggests that stress CMR is useful in not only diagnosing symptomatic CAD but also potentially important non-CAD-related disease. These factors may impact their use in ED-based ACS workups.
INVESTIGATIONS ON THE ULTIMATE COMPRESSIVE STRENGTH OF COMPOSITE PLATES WITH GEOMETRICAL IMPERFECTIONS (2009)

A series of studies has been performed within the MARSTRUCT Network of Excellence on Marine Structures in order to investigate the buckling response of glass fibre reinforced polymer plates. These studies include the fabrication, testing and finite element analysis of a large number of plates with initial geometric imperfections. This paper presents the validation of finite element models against a series of plate tests that were performed within this framework and parametric studies that were carried out to identify the effects of geometric imperfections on the ultimate compressive strength of composite plates with three alternative lay-up configurations.
Interaction of HIV RNA With Peptides Detected by Acoustic Shear Wave Sensor Operated in an On-line Format (2007)

Acoustic wave sensors are now widely used in various clinical applications because they allow real-time data to be rapidly obtained. In this chapter we describe the use of the thickness shear mode (TSM) acoustic wave sensor to study the interaction between the transactivation responsive region (TAR) of the HIV-1 mRNA and short peptides derived from the regulatory Tat protein as well as with two inhibitor molecules, namely neomycin and streptomycin. The interaction between the TAR-Tat system is a target for the development of antiviral drugs.
ChemInform Abstract: Besarhanamides A and B from the Marine Cyanobacterium Lyngbya majuscula. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Field grown Acacia mangium : how intensive is root growth? (1998)

Under rainfed conditions, root development of trees can be very unpredictable and variable, depending on the amount and distribution of rainfall received. This becomes more critical when the rainfall is seasonal and the soil has a high clay content. Our investigation dealt with the root development of Acacia mangium established as plantation forest on a soil with heavy clay texture in Kemasul Forest Reserve, Malaysia. The distribution of active roots was measured at 9- and 21-month-old plantations using the radioactive 32P injection method. Growth at different distances from the tree base and at different soil depths was studied. After nine months of field planting, we found that roots were mostly concentrated at the surface within 1000 mm distance from the tree base. At one year after the first measurement, roots were traced as far as 6400 mm away. A large part of these roots, however, were detected within 3700 mm distance in the upper 300mm soil. At this stage, roots still did not go deeper than 450 mm depth, probably due to the high clay content at lower depth and low pH. This rapid root growth indicates that below-ground competition can be very intense if this species is established as a mixed-species plantation.
ChemInform Abstract: Catalytic Bio—Chemo and Bio—Bio Tandem Oxidation Reactions for Amide and Carboxylic Acid Synthesis. (2015)

Abstract Three water‐based one‐pot cascades to convert aryl alcohols to acids and amides, respectively, and cyclic amines to lactams are realized.
MiR-155-5p positively regulates CCL17-induced colon cancer cell migration by targeting RhoA (2017)

Colorectal cancer is the second most common cause of cancer-related death, which is due to migration of tumor cells to distant sites of metastasis. Accumulating data indicate that mciroRNAs play an important role in several aspects of colon cancer cell biology. Herein, we examined the role of miR-155-5p in colon cancer cell migration induced by the CCL17-CCR4 axis in HT-29 colon cancer cells. We found that miR-155-5p knockdown in serum starved colon cancer cells decreased CCL17-induced cell chemotaxis. Moreover, knocking down miR-155-5p markedly decreased CCL17-provoked activation of RhoA in colon cancer cells. Bioinformatics analysis predicted two putative binding sites in the AU-rich element at the 3'-UTR of RhoA mRNA. MiR-155-5p binding to RhoA mRNA was verified using a target site blocker and functionally validated by RNA immunoprecipitation assays, showing that miR-155-5p-dependent regulation of RhoA mRNA is mediated by AU-rich elements present in the 3'-UTR region. Taken together, these results show that miR-155-5p positively regulates RhoA mRNA levels and translation as well as cell migration in serum starved colon cancer cells and indicate that targeting miR-155-5p might be a useful strategy to antagonize colon cancer metastasis.
60-Ghz OFDM Systems for Multi-Gigabit Wireless LAN Applications (2010)

This paper presents the developed 60-GHz OFDM hardware demonstrators and the newly designed 60-GHz system architecture targeting for multi-gigabit wireless LAN applications. The hardware demonstrators developed so far are made up of maximum 1-Gbps OFDM baseband realized on FPGA platform and 60-GHz super-heterodyne transceivers fabricated by SiGe BiCMOS technologies. Wireless transmission in 60-GHz links is successfully demonstrated in indoor office environments. The next generation 60-GHz OFDM systems are designed to provide data rate higher than 3-Gbps utilizing the channel bandwidth of 2.16-GHz. Advanced channel coding schemes including low-density-parity-check (LDPC) coding are applied to have higher coding gain. RF transceivers are based on sliding IF architecture and designed to be compatible to the channel plans defined in the 60-GHz standards.
Polybasic patches in both C2 domains of Synaptotagmin-1 are required for evoked neurotransmitter release (2021)

ABSTRACT Synaptotagmin-1 (Syt1) is a vesicular calcium sensor required for synchronous neurotransmitter release. It is composed of a single-pass transmembrane domain linked to two tandem C2 domains (C2A and C2B) that bind calcium, acidic lipids, and SNARE proteins that drive fusion of the synaptic vesicle with the plasma membrane. Despite its essential role, how Syt1 couples calcium entry to synchronous release is not well understood. Calcium binding to C2B, but not to C2A, is critical for synchronous release and C2B additionally binds the SNARE complex. The C2A domain is also required for Syt1 function, but it is not clear why. Here we asked what critical feature of C2A may be responsible for its functional role, and compared this to the analogous feature in C2B. We focused on highly conserved poly-lysine patches located on the sides of C2A (K189-192) and C2B (K324-327). We tested effects of charge-neutralization mutations in either region (Syt1 K189-192A and Syt1 K326-327A ) side-by-side to determine their relative contributions to Syt1 function in cultured cortical mouse neurons and in single-molecule experiments. Combining electrophysiological recordings and optical tweezers measurements to probe dynamic single C2 domain-membrane interactions, we show that both C2A and C2B polybasic patches contribute to membrane binding, and both are required for evoked release. The readily releasable vesicle pool or spontaneous release were not affected, so both patches are specifically required for synchronization of release. We suggest these patches contribute to cooperative binding to membranes, increasing the overall affinity of Syt1 for negatively charged membranes and facilitating evoked release. Significance Statement Synaptotagmin-1 is a vesicular calcium sensor required for synchronous neurotransmitter release. Its tandem cytosolic C2 domains (C2A and C2B) bind calcium, acidic lipids, and SNARE proteins that drive fusion of the synaptic vesicle with the plasma membrane. How calcium-binding to Synaptotagmin-1 leads to release and the relative contributions of the two C2 domains is not clear: unlike C2B, calcium-binding to C2A is not critical for evoked release, yet both domains are needed for Syt1 function. Combining electrophysiological recordings from cultured neurons and optical tweezers measurements that probe single C2 domain-membrane interactions, we show that conserved polybasic regions in both domains contribute to membrane binding cooperatively, and both are required for evoked release, likely by increasing the overall affinity of Synaptotagmin-1 for negatively charged membranes.
REFICS: A Step Towards Linking Vision with Hardware Assurance (2022)

Hardware assurance is a key process in ensuring the integrity, security and functionality of a hardware device. Its heavy reliance on images, especially on Scanning Electron Microscopy images, makes it an excellent candidate for the vision community. The goal of this paper is to provide a pathway for inter-community collaboration by introducing the existing challenges for hardware assurance on integrated circuits in the context of computer vision and support further development using a large-scale dataset with 800,000 images. A detailed benchmark of existing vision approaches in hardware assurance on the dataset is also included for quantitative insights into the problem.
Resorbable posterolateral graft containment in a rabbit spinal fusion model (2002)

A bioabsorbable protective graft containment device successfully enhanced posterolateral spinal fusion mass volume.
Mobile telephony through LEO satellites: To OBP or not (1991)

GLOBALSTAR is a satellite-based mobile communications system that is interoperable with the current and future Public Land Mobile Network (PLMN) and Public Switched Telephone Network (PSTN). The selection of the transponder type, bent-pipe, or onboard processing (OBP), for GLOBALSTAR is based on many criteria, each of which is essential to the commercial and technological feasibility of GLOBALSTAR. The trade study that was done to determine the pros and cons of a bent-pipe transponder or an onboard processing transponder is described. The design of GLOBALSTAR's telecommunications system is a multi-variable cost optimization between the cost and complexity of individual satellites, the number of satellites required to provide coverage to the service areas, the cost of launching the satellites into their selected orbits, the ground segment cost, user equipment cost, satellite voice channel capacity, and other issues. Emphasis is on the cost and complexity of the individual satellites, specifically the transponder type and the impact of the transponder type on satellite and ground segment cost, satellite power and weight, and satellite voice channel capacity.
Supplementary Figure S4 from Functional Kinomics Identifies Candidate Therapeutic Targets in Head and Neck Cancer (2023)

&lt;p&gt;Figure S4. Body weight of MK-1775 treated mice&lt;/p&gt;
Multiscale and multimodal reconstruction of cortical structure and function (2020)

Summary We present a semi-automated reconstruction of L2/3 mouse primary visual cortex from 3 million cubic microns of electron microscopic images, including pyramidal and inhibitory neurons, astrocytes, microglia, oligodendrocytes and precursors, pericytes, vasculature, mitochondria, and synapses. Visual responses of a subset of pyramidal cells are included. The data are being made publicly available, along with tools for programmatic and 3D interactive access. The density of synaptic inputs onto inhibitory neurons varies across cell classes and compartments. We uncover a compartment-specific correlation between mitochondrial coverage and synapse density. Frequencies of connectivity motifs in the graph of pyramidal cells are predicted quite accurately from node degrees using the configuration model of random graphs. Cells receiving more connections from nearby cells exhibit stronger and more reliable visual responses. These example findings illustrate the resource’s utility for relating structure and function of cortical circuits as well as for neuronal cell biology.
Design Considerations and Performance Trade-Offs for 56Gb/s Discrete Multi-Tone Electrical Link (2019)

For communicating over mid-to-long-reach electrical links at a data-rate above 56Gb/s, ADC-based receiver (RX) has become a dominant architecture due to its strong equalization capability using complex digital signal processing algorithm benefiting from the extreme process node shrinkage. This paper discusses the design of >56Gb/s DAC/ADC-based wireline transceiver (TRX) with discrete multi-tone (DMT) modulation. Some notable differences between wireless orthogonal frequency division multiplexing (OFDM) systems and wireline DMT systems are discussed, and some practical design considerations for a multiple tens-of-Gb/s DMT RX is provided.
Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes (2020)

We describe a strategy for the enantio- and diastereoselective synthesis of homoallylic α-trifluoromethyl amines by the catalytic hydroalkylation of terminal dienes. Trifluoromethyl-substituted isatin-derived azadienolate nucleophiles undergo γ-selective alkylation with a Pd-DTBM-SEGPHOS catalyst, which additionally promotes regioselective addition to the diene and delivers products in up to 86% yield, 10:1 dr, and 97.5:2.5 er.