gebhart/patrepeval huggingface dataset:
Improving Manipulation Capabilities of Autonomous Robots (2021)

Human-level manipulation continues to be beyond the capabilities of today’s robotic systems. Not only do current industrial robots require significant time to program a specific task, but they lack the flexibility to generalize to other tasks and be robust to changes in the environment. While collaborative robots help to reduce programming effort and improve the user interface, they still fall short on generalization and robustness. This talk will highlight recent advances in a number of key areas to improve the manipulation capabilities of autonomous robots, including methods to accurately model the dynamics of the robot and contact forces, sensors and signal processing algorithms to provide improved perception, optimization-based decision-making and control techniques, as well as new methods of interactivity to accelerate and enhance robot learning.
Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy (2015)

The majority of symptomatic peanut-allergic patients are sensitized to Ara h 2 and Ara h 6. In peanut-symptomatic patients with additional birch pollen allergy, other peanut allergens, especially Ara h 8, should be tested when IgE reactivity to Ara h 2 is absent.
Temperature and field dependence of critical currents in V&lt;inf&gt;3&lt;/inf&gt;Ga wire produced by the MJR technique (1985)

The temperature dependence of V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Ga multifilamentary wire produced by the modified jelly roll technique is reported as a function of applied magnetic field in the range 10K - 14K and 0-13T. Parameters which relate J <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</inf> to H at 4.2K were found to apply at these temperatures and fields. The form of the temperature dependence of the critical current density is compared with theory.
Centrality and pseudorapidity dependence of the transverse energy density inpPbcollisions atsNN=5.02TeV (2019)

The almost hermetic coverage of the CMS detector is used to measure the distribution of transverse energy, E T , over 13.2 units of pseudorapidity, , for pPb collisions at a center-of-mass energy per nucleon pair of s NN = 5.02 TeV. The huge angular acceptance exploits the fact that the CASTOR calorimeter at -6.6 < < -5.2 is effectively present on both sides of the colliding system because of a switch in the proton-going and lead-going beam directions. This wide acceptance enables the study of correlations between well-separated angular regions and makes the measurement a particularly powerful test of event generators. For minimum bias pPb collisions the maximum value of dE T /d is 22 GeV, which implies an E T per participant nucleon pair comparable to that of peripheral PbPb collisions at s NN = 2.76 TeV. The increase of dE T /d with centrality is much stronger for the lead-going side than for the proton-going side. The dependence of dE T /d is sensitive to the range in which the centrality variable is defined. Several modern generators are compared to these results but none is able to capture all aspects of the and centrality dependence of the data and the correlations observed between different regions.
Comment on ‘‘Alternative method of imaging surface topologies of nonconducting bulk specimens by scanning tunneling microscopy’’ (1992)

A Comment on the Letter by J.-Y. Yuan, Z. Shao, and C. Gao, Phys. Rev. Lett. 67, 863 (1991).Received 3 September 1991DOI:https://doi.org/10.1103/PhysRevLett.68.2563©1992 American Physical Society
Silhouette Fusion of Vascular and Anatomical Volume Data (2006)

In this paper we present a novel method for the combined hybrid visualization of the cerebral blood vessels, segmented from a 3D rotational angiography dataset, and datasets containing the soft tissue anatomy, such as CT or MR. This visualization method is targeted at the use in interventional treatment of vascular pathologies and endovascular treatment of the neoplastic tissue. Our method distinguishes itself since it offers the possibility to provide the clinician with a maximum amount of contextual information about the spatial relationship and topology of both datasets, without compromising the ease of use and interpretation. Further it is discussed how an interactive visualization can be implemented on off-the-shelf graphics hardware, and it is indicated which clinical benefits can be achieved.
Supplementary Table 2 from Endobronchial miRNAs as Biomarkers in Lung Cancer Chemoprevention (2023)

&lt;p&gt;PDF file - 36K, Distribution of histologies at BL and at FU in pairs of samples with best or worse histology at baseline. Legend : N=number, BL=baseline, FU=follow-up&lt;/p&gt;
Face Recognition by Projection-based 3D Normalization and Shading Subspace Orthogonalization. (2006)

This paper describes a new face recognition method using a projection-based 3D normalization and a shading subspace orthogonalization under variation in facial pose and illumination. The proposed method does not need any reconstruction and reillumination for a personalized 3D model, thus it can avoid these troublesome problems and the recognition process can be done rapidly. The facial size and pose including out of plane rotation can be normalized to a generic 3D model from one still image and the input subspace is generated by perturbed cropped patterns in order to absorb the localization errors. Furthermore, by exploiting the fact that a normalized pattern is fitted to the generic 3D model, illumination robust features are extracted through the shading subspace orthogonalization. Evaluation experiments are performed using several databases and the results show the effectiveness of our method under various facial poses and illuminations.
Identification of a Glycogen Synthase Kinase‐3β Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice (2011)

Bipolar disorder is characterized by a cycle of mania and depression, which affects approximately 5 million people in the United States. Current treatment regimes include the so-called "mood-stabilizing drugs", such as lithium and valproate that are relatively dated drugs with various known side effects. Glycogen synthase kinase-3β (GSK-3β) plays a central role in regulating circadian rhythms, and lithium is known to be a direct inhibitor of GSK-3β. We designed a series of second generation benzofuran-3-yl-(indol-3-yl)maleimides containing a piperidine ring that possess IC₅₀ values in the range of 4 to 680 nM against human GSK-3β. One of these compounds exhibits reasonable kinase selectivity and promising preliminary absorption, distribution, metabolism, and excretion (ADME) data. The administration of this compound at doses of 10 to 25 mg kg⁻¹ resulted in the attenuation of hyperactivity in amphetamine/chlordiazepoxide-induced manic-like mice together with enhancement of prepulse inhibition, similar to the effects found for valproate (400 mg kg⁻¹) and the antipsychotic haloperidol (1 mg kg⁻¹). We also tested this compound in mice carrying a mutation in the central transcriptional activator of molecular rhythms, the CLOCK gene, and found that the same compound attenuates locomotor hyperactivity in response to novelty. This study further demonstrates the use of inhibitors of GSK-3β in the treatment of manic episodes of bipolar/mood disorders, thus further validating GSK-3β as a relevant therapeutic target in the identification of new therapies for bipolar patients.
Impact of Pattern Recognition Receptors on the Prognosis of Breast Cancer Patients Undergoing Adjuvant Chemotherapy (2016)

Pattern recognition receptors allow the innate immune system to perceive the presence of microbial products and to launch the first steps of the defense response. Some pattern recognition receptors also sense endogenous ligands that are released from uninfected dying cells, thereby activating immune responses against dead-cell antigens. This applies to toll-like receptors 3 and 4 (TLR3, TLR4), which sense double-stranded RNA and high-mobility group protein B1 (HMGB1), respectively, as well as to formyl peptide receptor-1 (FPR1), which interacts with Annexin A1 (ANXA1) from dead cells. Breast cancer patients who bear loss-of-function alleles in TLR3, TLR4, and FPR1 exhibit a reduced metastasis-free and overall survival after treatment with anthracycline-based adjuvant chemotherapy. These genetic defects are epistatic with respect to each other, suggesting that they act on the same pathway, linking chemotherapy to a therapeutically relevant anticancer immune response. Loss-of-function alleles in TLR4 and FPR1 also affect the prognosis of colorectal cancer patients treated with oxaliplatin-based chemotherapy. Altogether, these results support the idea that conventional anticancer treatments rely on stimulation of anticancer immune responses to become fully efficient. Cancer Res; 76(11); 3122-6. ©2016 AACR.
Heterogeneity of resistance mutations detectable by next-generation sequencing in TKI-treated lung adenocarcinoma (2016)

EGFR-mutated lung adenocarcinomas routinely develop resistance to tyrosine kinase inhibitors (TKI). To better characterize the relative frequencies of the resistance mechanisms, we analyzed 48 EGFR-mutated TKI-resistant specimens from 41 patients. Next-generation sequencing of post-treatment specimens detected EGFR p.T790M in 31 (79%) of 39 patients, PIK3CA mutations in 10 (26%), EGFR p.S768_V769delinsIL in one, and KRAS p.G12C in one. Five PIK3CA mutations were outside of codons 542, 545, and 1047. Three of four pre-treatment specimens did not carry the PIK3CA mutation found in the post-treatment sample. Small cell carcinoma transformation was identified in four patients; none had p.T790M, including two where p.T790M was identified in the co-existing adenocarcinoma. In p.T790M-mutated specimens, the allele frequency was less than 5% in 24% of cases. p.T790M allele frequency was usually lower than that of the sensitizing mutation indicating that the resistance mutation was present either in a subset of cells or, if the sensitizing mutation was amplified, in a subset of the sensitizing alleles of a dominant clone. Eight patients had multiple resistance mutations, suggesting either multiple separate resistant clones or a single clone harboring multiple resistance mechanisms. PIK3CA mutations appear to be a more significant resistance mechanism than previously recognized.
Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2) (1992)

Using the human hepatoma cell line Hep G2, we have studied a possible role of protein kinase C (PKC) activity for regulation of erythropoietin (EPO) production. During a 72-h incubation, EPO production by the cells was stimulated sevenfold by exposure to low oxygen tension (1%) and threefold by exposure to cobaltous chloride (100 microM). The phorbol ester phorbol 12-myristate-13 acetate (PMA) led to a concentration-dependent inhibition of basal and stimulated EPO formation (ED50 10 nM). This decrease of EPO production, which was apparent already after 1 h of incubation with PMA, reached its maximal effect after 24 h and held on for 72 h. It was paralleled by an inhibition of the increase of EPO mRNA levels in response to stimulation. A 24-h preincubation of the cells with PMA (100 nM) virtually blunted the effect of hypoxia on EPO formation. Recovery of EPO synthesis after removal of PMA took 48-72 h. The effect of PMA on EPO production was mimicked by phorbol 12,13-dibutyrate (ED50 1 microM) but not by 4 alpha-phorbol 12,13-didecanoate. The synthetic diacylglycerol analogues oleolyl-acetylglycerol and dioctanoylglycerol (2-200 microM) also had no effect on either basal or stimulated EPO production. Treatment with PMA caused a translocation of the alpha-isoenzyme of PKC from the cytosol to the membrane after 1 h and a disappearance of the membrane-bound form after 24 h of incubation. Staurosporine and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, two structurally different inhibitors of PKC activity, inhibited basal and stimulated EPO production with ED50 values of 9 nM and 50 microM, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Characterizing and modeling the efficiency limits in large-scale production of hyperpolarizedXe129 (2014)

The ability to produce liter volumes of highly spin-polarized <sup>129</sup>Xe enables a wide range of investigations, most notably in the fields of materials science and biomedical MRI. However, for nearly all polarizers built to date, both peak <sup>129</sup>Xe polarization and the rate at which it is produced fall far below those predicted by the standard model of Rb metal vapor, spin-exchange optical pumping (SEOP). In this work, we comprehensively characterized a high-volume, flow-through <sup>129</sup>Xe polarizer using three different SEOP cells with internal volumes of 100, 200 and 300 cc and two types of optical sources: a broad-spectrum 111-W laser (FWHM = 1.92 nm) and a line-narrowed 71-W laser (FWHM = 0.39 nm). By measuring <sup>129</sup>Xe polarization as a function of gas flow rate, we extracted peak polarization and polarization production rate across a wide range of laser absorption levels. Peak polarization for all cells consistently remained a factor of 2-3 times lower than predicted at all absorption levels. Moreover, although production rates increased with laser absorption, they did so much more slowly than predicted by the standard theoretical model and basic spin exchange efficiency arguments. Underperformance was most notable in the smallest optical cells. We propose that all these systematic deviations from theory can be explained by invoking the presence of paramagnetic Rb clusters within the vapor. Cluster formation within saturated alkali vapors is well established and their interaction with resonant laser light was recently shown to create plasma-like conditions. Such cluster systems cause both Rb and <sup>129</sup>Xe depolarization, as well as excess photon scattering. These effects were incorporated into the SEOP model by assuming that clusters are activated in proportion to excited-state Rb number density and by further estimating physically reasonable values for the nanocluster-induced, velocity-averaged spin-destruction cross-section for Rb (<σ<sub>cluster-Rb</sub>v> ≈4×10<sup>-7</sup> cm<sup>3</sup>s<sup>-1</sup>), <sup>129</sup>Xe relaxation cross-section (<σ<sub>cluster-Xe</sub>v> ≈ 4×10<sup>-13</sup> cm<sup>3</sup>s<sup>-1</sup>), and a non-wavelength-specific, photon-scattering cross-section (σ<sub>cluster</sub> ≈ 1×10<sup>-12</sup> cm<sup>2</sup>). The resulting modified SEOP model now closely matches experimental observations.
Efficacy of manipulation under anesthesia beyond three months following total knee arthroplasty (2019)

Early and late MUA resulted in statistically equivalent gains in ROM, regardless of timing after TKA. All groups showed an average improvement in ROM of ≥11°. MUA performed beyond 3 months, and even beyond 1 year, appears to be safe and may improve ROM and allow select patients to avoid revision surgery.
Abstract PD01-01: Cetuximab + Cisplatin in Estrogen Receptor-Negative, Progesterone Receptor-Negative, HER2-Negative (Triple-Negative) Metastatic Breast Cancer: Results of the Randomized Phase II BALI-1 Trial (2010)

Abstract Background: The epidermal growth factor receptor (EGFR) plays a role in triple-negative (estrogen receptor-, progesterone receptor-, HER2-negative) breast cancer (TNBC). This randomized, phase II study investigated the combination of the EGFR monoclonal antibody cetuximab and cisplatin in the treatment of metastatic (m) TNBC. Methods: Patients (pts) with mTNBC who had received ≥1 prior chemotherapy regimen for metastatic disease, were randomized 2:1 to treatment with either: cetuximab (400 mg/m2 initial dose then 250 mg/m2 weekly) + ≥6x 3-weekly cycles of cisplatin (75 mg/m2, d1); or ≥6x 3-weekly cycles of cisplatin alone. In the cisplatin arm, pts with disease progression (PD) during the 6 cisplatin cycles could switch to cetuximab plus cisplatin and those with PD after the 6 cycles could receive cetuximab alone. The primary endpoint was best overall response. Simultaneous null hypotheses assumed that the overall response rate (ORR) in the combination arm was ≥20% and that the ORRs were equal in both arms. Secondary endpoints included progression-free survival (PFS), overall survival (OS) and safety. All statistical tests were performed at alpha-level 0.1 Results: 173 pts were included in the intention-to-treat population: 115 were randomized to cetuximab/cisplatin and 58 to cisplatin. The cetuximab/cisplatin and cisplatin arms were well balanced for patient and disease characteristics (randomization strata, 73% first and 27% second line in both arms). Differences included: age ≥65 years (19.1% vs 12.1%) and lung metastases (55.7% vs 44.8%). 30 pts receiving cisplatin alone switched to cetuximab/cisplatin after first PD. 79.6% of patients on cetuximab/cisplatin and 73.7% on cisplatin received ≥90% of the relative dose intensity of cisplatin. Adverse events (AEs) were manageable and in line with what was expected from the different agents (grade 3/4 AEs are shown in the Table). Grade 3/4 AEs (%) Adding cetuximab to cisplatin nearly doubled the ORR: 20.0% (95% CI 13.1%, 28.5%) vs 10.3% (95% CI 3.9%, 21.2%) (p=0.5 for testing ORR against 20.0%), with an odds ratio of 2.126 (90% CI 0.945, 4.786, p=0.11). Cetuximab/cisplatin was associated with a significant 32.5% reduction in the risk of disease progression compared with cisplatin alone HR 0.675 (95% CI 0.470, 0.969, p=0.032). Median PFS times were 3.7 and 1.5 months, respectively. The benefits of cetuximab/cisplatin over cisplatin on ORR and PFS were observed consistently across sub-groups (according to patient, disease and treatment characteristics), but sample sizes were small. OS results will be presented at the meeting. Conclusions: Adding cetuximab to cisplatin increased the ORR compared with cisplatin alone and significantly improved PFS in mTNBC. Safety was manageable. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr PD01-01.
ChemInform Abstract: Carbohydrates as Chiral Auxiliaries: Asymmetric Cyclopropanation Reaction of Acyclic Olefins. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics (2000)

Phenserine, a phenylcarbamate of physostigmine, is a new potent and highly selective acetylcholinesterase (AChE) inhibitor, with a > 50-fold activity versus butyrylcholinesterase (BChE), in clinical trials for the treatment of Alzheimer's disease (AD). Compared to physostigmine and tacrine, it is less toxic and robustly enhances cognition in animal models. To determine the time-dependent effects of phenserine on cholinergic function, AChE activity, brain and plasma drug levels and brain extracellular acetylcholine (ACh) concentrations were measured in rats before and after phenserine administration. Additionally, its maximum tolerated dose, compared to physostigmine and tacrine, was determined. Following i.v. dosing, brain drug levels were 10-fold higher than those achieved in plasma, peaked within 5 min and rapidly declined with half-lives of 8.5 and 12.6 min, respectively. In contrast, a high (> 70%) and long-lasting inhibition of AChE was achieved (half-life > 8.25 h). A comparison between the time-dependent plasma AChE inhibition achieved after similar oral and i.v. doses provided an estimate of oral bioavailability of 100%. Striatal, in vivo microdialysis in conscious, freely-moving phenserine-treated rats demonstrated > 3-fold rise in brain ACh levels. Phenserine thus is rapidly absorbed and cleared from the body, but produces a long-lasting stimulation of brain cholinergic function at well tolerated doses and hence has superior properties as a drug candidate for AD. It selectively inhibits AChE, minimizing potential BChE side effects. Its long duration of action, coupled with its short pharmacokinetic half-life, reduces dosing frequency, decreases body drug exposure and minimizes the dependence of drug action on the individual variations of drug metabolism commonly found in the elderly.
Prehypertension and Retinal Arteriolar Narrowing in PWH in Tanzania (2022)

Woodward, Richmond MDa; Fadhil, Salama BAScb; Kisigo, Godfrey MD, MScc; O'Donnell, Philip MDd,e; Mwanansao, Christopher MDf; Wong, Tien Yin MBBS, MMed(Ophth), PhDg,h; Cheung, Carol Y. PhDi; Hamzah, Haslina BScg; McNairy, Margaret MDc; Peck, Robert MDj,c Author Information
Modeling and capturing the human body (2015)

Modeling the human body is of special interest in computer graphics to create "virtual humans", but material and optical properties of biological tissues are complex and not easily captured. This course will cover the major topics and challenges in using image acquisition to model the human body.
Effects of Sacubitril-Valsartan Versus Valsartan in Women Compared With Men With Heart Failure and Preserved Ejection Fraction (2019)

https://www.clinicaltrials.gov. Unique identifier: NCT01920711.
SPEEK/cSMM membrane for simultaneous electricity generation and wastewater treatment in microbial fuel cell (2014)

Abstract BACKGROUND Sulfonated poly (ether ether ketone) ( SPEEK ) membranes and their modifications are viewed as arguably the most promising in microbial fuel cell (MFC) applications due to their non‐fluorinated base, superior chemical stability, and lower costs compared with Nafion membranes. In this work, SPEEK membranes with different degrees of sulfonation ( DSs ) (60% to 76%) and blended with charged surface modifying macromolecule (cSMM) were used as electrolytes in an MFC for simultaneous electricity generation and wastewater treatment. RESULTS Performance evaluation of newly fabricated membranes was carried out and was compared with that of Nafion 117. The MFC with SPEEK76/cSMM generated about 16.5% higher maximum power density (172.1 mW m −2 ) than that with Nafion 117 (143.7 mW m −2 ). In addition, the SPEEK76 / cSMM exhibited the highest coulombic efficiency (CE) of 17.6%, which was 21.6% higher than that of Nafion 117 (13.8%). Chemical oxygen demand ( COD ) removal of all characterized membranes was above 80% in our particular MFC . CONCLUSION MFC is a suitable method for simultaneous wastewater treatment and electricity generation. SPEEK76 / cSMM is a promising membrane to be applied in MFC . © 2014 Society of Chemical Industry