gebhart/patrepeval huggingface dataset:
Influence of cholestyramine resin administration on single dose sulindac pharmacokinetics. (1994)

Cholestyramine, a nonabsorbable anion exchange resin, has been reported to bind concomitantly administered drugs and decrease their bioavailability. The objective of the study was to determine cholestyramine effect on the plasma concentrations of sulindac and its sulfide metabolite following concurrent and staggered (sulindac 3 hours before cholestyramine) dosing. Six healthy volunteers participated in an open-label, 3-way crossover study. Subjects received 400 mg sulindac orally followed by serial blood sampling for sulindac and sulindac sulfide plasma concentrations over a 24-hour period. During the concurrent phase, 4 g of cholestyramine was coadministered resulting in a decrease (p < 0.05) in the area under the curve (AUC) for sulindac compared to sulindac alone (7.11 +/- 3.25 micrograms-h/ml vs 31.65 +/- 7.94 micrograms-h/ml respectively). Also, the sulindac sulfide AUC decreased (p < 0.05) to 7.26 +/- 4.37 micrograms-h/ml coadministration of both drugs compared to 44.69 +/- 11.81 micrograms-h/ml when sulindac is given alone. When the same doses of each drug were given 3 hours apart, the AUC for sulindac (17.88 +/- 3.69 micrograms-h/ml) and its sulfide metabolite (20.12 +/- 7.46 micrograms-h/ml) were still significantly decreased (p < 0.05) when compared to sulindac given alone (31.65 +/- 7.94 micrograms-h/ml for sulindac and 44.69 +/- 11.81 micrograms-h/ml for sulindac sulfide). Based on the lower AUCs for sulindac and sulindac sulfide, separating sulindac and cholestyramine by 3-hour intervals did not prevent the interaction. It is likely that the enterohepatic recycling features of sulindac may not prevent the interaction with cholestyramine even when the 2 drugs are staggered.
Model study by FT-IR of the interaction of select cholate dissolution inhibitors with poly(norbornene-alt-maleic anhydride) and its derivatives (1999)

The fundamental nature of the interaction between the polymer matrix and the cholate based dissolution inhibitors are being studied by Fourier Transform-IR (FTIR) spectroscopy. It was found that the simple cholate derivatives undergo, in a blend with poly(norbornene-alt- maleic anhydride) and in a blend with the terpolymers poly(norbornene-alt-maleic anhydride-co-t-butylacrylate) and poly(norbornene-alt-maleic anhydride-co-acrylic acid), stronger interaction as seen by shifts in the OH region of the spectra than do blends with dimeric or oligomeric cholates.
Impaction Allografting with Cement for Revision of the Femoral Component (1999)

Difficult revisions of the femoral component with use of impaction allografting and a precoated stem provided satisfactory clinical and radiographic results at the time of intermediate-term follow-up. However, the high rate of complications in our series led us to refine our indications for the procedure.
Technical considerations of total knee arthroplasty after proximal tibial osteotomy. (1988)

Forty-five total knee replacements in forty-one patients who had continued to have progressive osteoarthritis after a proximal tibial osteotomy were evaluated prospectively. There were 51 per cent excellent, 29 per cent good, 4 per cent fair, and 16 per cent poor results after a minimum follow-up of two years. The resection of tibial bone that was produced by the osteotomy could not be related causally to the fair or poor clinical results that were found after arthroplasty. Radiographic study, however, showed that 80 per cent of the knees had patella infera before the arthroplasty, which may contribute to altered biomechanics of the patellofemoral joint of the arthroplasty. The procedure for total knee replacement is made more difficult by the previous osteotomy, and a custom-made prosthesis may be required. The clinical results that were obtained in this series are similar to those for the revision total knee arthroplasties that have been done at this institution, but they were not as satisfactory as those that were obtained after primary total knee replacement. Our results should be considered when a surgeon compares the advantages and disadvantages of proximal tibial osteotomy with those of total knee arthroplasty for an older patient who has unicompartmental osteoarthritis of the knee.
An optimized method for measuring cyclosporin A with 125I-labeled cyclosporin. (1986)

Abstract We evaluated the use of the new iodinated ligand for the in vitro measurement of cyclosporin A by radioimmunoassay (RIA). Substitution of the iodinated cyclosporin (125I-CyA) for the corresponding tritium-labeled analog (3H-CyA) considerably simplifies and accelerates the currently available RIA, and improves its precision. Analysis of the respective dose-response curves showed that the 50% B0 value was lower for the 125I-CyA assay than for the 3H-CyA assay (37 vs 77 micrograms/L). Use of whole-blood specimens minimized interferences from temperature and hematocrit. We conclude that the use of 125I-CyA in a commercially available RIA for whole-blood specimens is accessible to most laboratories and provides rapid, reproducible data for management of transplant patients.
Physics-Guided Reflection Separation From a Pair of Unpolarized and Polarized Images (2022)

Undesirable reflections contained in photos taken in front of glass windows or doors often degrade visual quality of the image. Separating two layers apart benefits both human and machine perception. The polarization status of the light changes after refraction or reflection, providing more observations of the scene, which can benefit the reflection separation. Different from previous works that take three or more polarization images as input, we propose to exploit physical constraints from a pair of unpolarized and polarized images to separate reflection and transmission layers in this paper. Due to the simplified capturing setup, the system is more under-determined compared to the existing polarization-based works. In order to solve this problem, we propose to estimate the semi-reflector orientation first to make the physical image formation well-posed, and then learn to reliably separate two layers using additional networks based on both physical and numerical analysis. In addition, a motion estimation network is introduced to handle the misalignment of paired input. Quantitative and qualitative experimental results show our approach performs favorably over existing polarization and single image based solutions.
Impact of EMC Filters on the Power Density of Modern Three-Phase PWM Converters (2009)

Electromagnetic compatibility (EMC) filters are typically included in offline power converters, controlling electromagnetic emissions, but adding volume to power electronic systems. During the last decades, one of the main objectives of the power electronics industry has been the increase of the power density. Thus, it is reasonable to analyze how filters affect power density values, imposing limits or ldquobarriersrdquo to it. The impact of the EMC filters on the overall volume of three-phase pulsewidth modulation (PWM) converters is studied here for converters in the range of 5-10 kW. An analytical procedure based on the volume minimization of the EMC filters is proposed to estimate the total filter volume as function of the converters' rated power and switching frequency. With this, the minimum volume for EMC filters that allow the converters to comply with EMC standards regarding conducted emissions can be estimated and volume limitations identified. A discussion about the limits of power density for the considered three-phase PWM converters for state-of-the-art power semiconductors is performed, and optimum switching frequencies are identified. An experimental verification is carried out, which validates the achieved results.
Detection of oxidative damage by 32P-postlabelling: 8-hydroxydeoxyguanosine as a marker of exposure. (1993)

Human exposure to reactive oxygen species is unavoidable and has been implicated in the etiology of a number of human diseases. This exposure results in the formation of various modified DNA bases: the promutagenic lesion 8-hydroxydeoxyguanosine (8OHdG), in particular, is a major product. We have developed an assay using ion-pair HPLC and 32P-postlabelling to quantify 8OHdG in human DNA with high specificity and sensitivity. An internal standard is used to account for variations in labelling efficiency. Chemically synthesized 8OHdG 3'-monophosphate and 5'-monophosphate standards were used to optimize the HPLC-32P-postlabelling and TLC separative steps, respectively. The assay was validated using known ratios of 8OHdG to normal nucleotides. The limit of detection is in the range of one 8OHdG residue per 10(6)-10(7) dG residues. Using this procedure, 8OHdG levels of 16-35 8OHdG adducts per 10(5) dG residues have been found in leukocytes isolated from patients who received 180-200 cGy of ionizing radiation. These levels were 2-4-fold greater than those found in an unexposed individual. Since 8OHdG may be formed during DNA extraction and digestion, current procedures for measuring background levels are discussed.
Long-Term Neurological Consequences Related to Boxing and American Football: A Review of the Literature (2019)

The long-term effects of repetitive head trauma on the brain have often been studied in boxers and American football players. The medical literature on this topic was reviewed in order to compare the findings related to boxing with those related to football. The evidence gathered from this review indicates that there are significant differences between the clinical and neuropathological descriptions of the chronic brain damage reported in retired boxers compared to those reported in retired football players. Differing biomechanics of head impacts in the two sports may help explain the different clinical and neuropathological consequences of participation in boxing versus football.
A mixed-signal multiplexing system for cable-count reduction in ultrasound probes (2015)

This paper presents an approach to time-multiplexing multiple receive signals in a miniature ultrasound probe onto a single micro-coaxial cable. The resulting reduction in the number of receive cables alleviates the design of high-element-count endoscope- or catheter-based ultrasound probes. A prototype multiplexing system is presented that employs a custom multiplexing chip that uses current-mode drivers to combine four receive channels, sampled at 25 MHz each, on a single 3-m micro-coaxial cable. On the system-side of the cable, a transimpedance amplifier turns the multiplexed signal back into a voltage, after which it is digitized and equalized to correct for channel-to-channel crosstalk due to non-idealities of the cable. The chip has been implemented in a 0.18 µm CMOS process and consumes less than 1 mW per input channel. Experimental results show that the system can successfully convey 6 MHz Gaussian-shaped pulses applied to the four input channels of the multiplexing chip to the system with a channel-to-channel crosstalk below −31 dB.
Evidence for the Formation and Structure of Palladacycles during Pd‐Catalyzed CN Bond Formation with Catalysts Derived from Bulky Monophosphinobiaryl Ligands (2006)

Die strukturellen Grundlagen der unterschiedlichen Katalysatoraktivität von Systemen mit 2′-substituierten und 2′,6′-disubstituierten Biarylmonophosphanliganden bei Pd-katalysierten C-N-Verknüpfungen wurden untersucht. Mit 2′,6′-disubstituierten Liganden wird die Bildung von Palladacyclen verhindert und eine optimale Katalysatoraktivität erzielt. (tAm=tert-Amyl, dppe=1,2-Bis(diphenylphosphanyl)ethan).
Learning probabilistic prediction functions (1988)

The question of how to learn rules, when those rules make probabilistic statements about the future, is considered. Issues are discussed that arise when attempting to determine what a good prediction function is, when those prediction functions make probabilistic assumptions. Learning has at least two purposes: to enable the learner to make predictions in the future and to satisfy intellectual curiosity as to the underlying cause of a process. Two results related to these distinct goals are given. In both cases, the inputs are a countable collection of functions which make probabilistic statements about a sequence of events. One of the results shows how to find one of the functions, which generated the sequence, the other result allows to do as well in terms of predicting events as the best of the collection. In both cases the results are obtained by evaluating a function based on a tradeoff between its simplicity and the accuracy of its predictions. >
The synthesis of some perhydrophenanthrene derivatives (1954)

C. Buchanan and A. C. Ritchie, J. Chem. Soc., 1954, 4523 DOI: 10.1039/JR9540004523
Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate (2015)

Autotaxin (ATX) is a secreted enzyme, which produces extracellular lysophosphatidate (LPA) from lysophosphatidylcholine (LPC). LPA activates six G protein-coupled receptors and this is essential for vasculogenesis during embryonic development. ATX is also involved in wound healing and inflammation, and in tumor growth, metastasis, and chemo-resistance. It is, therefore, important to understand how ATX is regulated. It was proposed that ATX activity is inhibited by its product LPA, or a related lipid called sphingosine 1-phosphate (S1P). We now show that this apparent inhibition is ineffective at the high concentrations of LPC that occur in vivo. Instead, feedback regulation by LPA and S1P is mediated by inhibition of ATX expression resulting from phosphatidylinositol-3-kinase activation. Inhibiting ATX activity in mice with ONO-8430506 severely decreased plasma LPA concentrations and increased ATX mRNA in adipose tissue, which is a major site of ATX production. Consequently, the amount of inhibitor-bound ATX protein in the plasma increased. We, therefore, demonstrate the concept that accumulation of LPA in the circulation decreases ATX production. However, this feedback regulation can be overcome by the inflammatory cytokines, TNF-α or interleukin 1β. This enables high LPA and ATX levels to coexist in inflammatory conditions. The results are discussed in terms of ATX regulation in wound healing and cancer.
Biomechanical and Hemodynamic Measures of Right Ventricular Diastolic Function: Translating Tissue Biomechanics to Clinical Relevance (2017)

RV pressure overload in PAB rats resulted in an increase in diastolic myocardial stiffness reflected both hemodynamically, by an increase in E<sub>ed</sub>, and biomechanically, by an increase in longitudinal E<sub>1</sub>. Modest increases in tissue biomechanical stiffness are associated with large increases in E<sub>ed</sub>. Hemodynamic measurements of RV diastolic function can be used to predict biomechanical changes in the myocardium.
Field deployable OC-192 optically amplified transport network (2002)

Summary form only given. In a continuing effort to increase network capacity while reducing recurring capital costs, MCI is performing field trials in conjunction with two major transmission equipment manufacturers on production quality OC-192, 2 X 2 (four wavelength) bidirectional optical line amplifiers, and passive optical dispersion compensation techniques. The objective of this trial is to confirm the technology performance and identify deployment implications to the network in a field environment. The OC-192 terminals and regenerators with power amplifiers, receiver preamplifiers, bidirectional line amplifiers, and fiber Bragg grating technologies are being field tested on a 443-km route. These technologies will be deployed on all MCI fiber types (NDSF, DSF, LS). MCI does not endorse only wavelength-division multiplexing (WDM) as the solution to increasing network capacity, but rather the use of the combination merits of both high-speed TDM and WDM along with bidirectional line amplification.
Involvement of C3a and C5a in Interleukin-8 Secretion by Human Polymorphonuclear Cells in Response to Capsular Material of Cryptococcus neoformans (1998)

In a previous paper we demonstrated that human polymorphonuclear cells (PMN) in the presence of normal human serum (NHS) secrete proinflammatory cytokines in response to Cryptococcus neoformans or its major capsular component, glucuronoxylomannan (GXM). The hypothesis that activation of the complement system could be responsible for the observed phenomenon is supported by the fact that encapsulated and acapsular C. neoformans isolates are activators of the complement system and, in particular, large encapsulated isolates are powerful activators. In the present study we demonstrate that (i) interleukin-8 (IL-8) release in response to acapsular or encapsulated strains of C. neoformans is significantly reduced in the presence of heat-inactivated serum rather than NHS and is completely abrogated in the absence of human serum; (ii) GXM-induced IL-8 release is strictly dependent on the presence of NHS, is inhibited by specific antibodies to either C3a and C5 complement components, and is completely abrogated by the combined use of these antibodies; (iii) the addition of purified C3a and C5a directly stimulates IL-8 release by PMN; and (iv) monoclonal antibody to GXM in combination with GXM or encapsulated C. neoformans potentiates IL-8 release by PMN. These data shed light on the mechanism involved in GXM-induced IL-8 secretion by PMN, provide an additional potential role for complement in the control of C. neoformans infections, and suggest a complex interplay between the complement system, humoral immunity, and cytokine regulation.
Inhibiting DNA methylation as a strategy to enhance adipose-derived stem cells differentiation: Focus on the role of Akt/mTOR and Wnt/β-catenin pathways on adipogenesis (2022)

Adipose-derived mesenchymal stem cells (ASCs) represent a valid therapeutic option for clinical application in several diseases, due to their ability to repair damaged tissues and to mitigate the inflammatory/immune response. A better understanding of the underlying mechanisms regulating ASC biology might represent the chance to modulate their <i>in vitro</i> characteristics and differentiation potential for regenerative medicine purposes. Herein, we investigated the effects of the demethylating agent 5-azacytidine (5-aza) on proliferation, clonogenicity, migration, adipogenic differentiation and senescence of ASCs, to identify the molecular pathways involved. Through functional assays, we observed a detrimental effect of 5-aza on ASC self-renewal capacity and migration, accompanied by actin cytoskeleton reorganization, with decreased stress fibers. Conversely, 5-aza treatment enhanced ASC adipogenic differentiation, as assessed by lipid accumulation and expression of lineage-specific markers. We analyzed the involvement of the Akt/mTOR, MAPK and Wnt/β-catenin pathways in these processes. Our results indicated impairment of Akt and ERK phosphorylation, potentially explaining the reduced cell proliferation and migration. We observed a 5-aza-mediated inhibition of the Wnt signaling pathway, this potentially explaining the pro-adipogenic effect of the drug. Finally, 5-aza treatment significantly induced ASC senescence, through upregulation of the p53/p21 axis. Our data may have important translational implications, by helping in clarifying the potential risks and advantages of using epigenetic treatment to improve ASC characteristics for cell-based clinical approaches.
Amorphous silicon current steering digital to analog converter (2011)

A 6-bit current steering D/A converter (DAC) is built using only n-channel amorphous silicon (a-Si:H) thin film transistors (TFT) and capacitors. The circuit is built on silicon using a low temperature process, compatible with flexible plastic substrates. The measurements show reasonably good characteristics, achieving a DNL of less than ±1.2 LSB and INL of less than ±1.8 LSB without calibration, at a conversion rate of 500 Hz.
Thermal Analysis of Polymers (1990)

Thermal analysis embraces a group of analytical methods in which a physical property - e.g. enthalpy, mass, volume or birefringence - is measured as a function of temperature. This paper briefly presents differential scanning calorimetry (DSC), differential thermal analysis (DTA), thermogravimetry (TG), thermal mechanical analysis (TMA) and thermal optical analysis (TOA) as methods and describes in more detail their application on polymers. Examples are presented to demonstrate that the use of these methods and the interpretation of the results obtained requires special attention. The non-equilibrium nature of different polymers is illustrated by the melting and crystallization behaviour of flexible-chain polymers, the glass transition of amorphous polymers and phase transitions in liquid crystalline polymers. The information provided by thermal analysis about the morphology of crystalline polymers, the morphology of polymer blends and the chemical stability of polymers is also discussed.
Noncollinear Remanent Textures Induced by Surface Spin Flop in Synthetic Antiferromagnets with Perpendicular Anisotropy (2021)

The surface spin flop, observed in synthetic antiferromagnets (SAFs) with uniaxial anisotropy and strong antiferromagnetic (AF) interlayer exchange coupling, can be considered as a laterally homogeneous, vertical AF domain wall pushed into the SAF from either the top or the bottom in the presence of a strong external vertical magnetic field. As a result, the AF domain wall can be described as a one-dimensional entity. In this work, we present a concept to stabilize laterally homogeneous vertical AF domain walls by local variation of the perpendicular magnetic anisotropy in $\mathrm{Co}/\mathrm{Pt}$-based SAFs. Our approach not only allows the stabilization of the vertical AF domain wall in the absence of any external magnetic field, but furthermore enables a deterministic selection among four different remanent states, each one stable within a broad external magnetic field range of almost one tesla. We also demonstrate an extension to our concept by stabilizing two coexisting vertical AF domain walls, thus yielding a system with a total of six different selectable (and reprogrammable) remanent states. The controlled stabilization of noncollinear AF textures in the form of vertical AF domain walls at remanence could be used as an infrastructure for propagating spin waves within the AF domain wall itself, as well as for tuning the dynamic behavior of perpendicular standing spin wave modes existing vertically across the SAF.
Photometric computation of the sign of Gaussian curvature using a curve-orientation invariant (2002)

The authors compute the sign of Gaussian curvature using a purely geometric definition. Consider a point p on a smooth surface S and a closed curve /spl gamma/ on S which encloses p. The image of /spl gamma/ on the unit normal Gaussian sphere is a new curve /spl beta/. The Gaussian curvature at p is defined as the ratio of the area enclosed by /spl gamma/ over the area enclosed by /spl beta/ as /spl gamma/ contracts to p. The sign of Gaussian curvature at p is determined by the relative orientations of the closed curves /spl gamma/ and /spl beta/. They directly compare the relative orientation of two such curves from intensity data. They employ three unknown illumination conditions to create a photometric scatter plot. This plot is in one-to-one correspondence with the subset of the unit Gaussian sphere containing the mutually illuminated surface normals. This permits direct computation of the sign of Gaussian curvature without the recovery of surface normals. Their method is albedo invariant. They assume diffuse reflectance, but the nature of the diffuse reflectance can be general and unknown. Simulations, as well as empirical results, demonstrate the accuracy of the technique.