gebhart/patrepeval huggingface dataset:
Preparation and Characterization of Amino Acids-Based Trimethoprim Salts (2012)

Trimethoprim (TMP) is a dihydrofolate reductase (DHFR) inhibitor which prevents the conversion of dihydrofolic acid into tetrahydrofolic acid, resulting in the depletion of the latter and leading to bacterial death. Oral bioavailability of TMP is hindered by both its low solubility and low permeability. This study aims to prepare novel salts of TMP using anionic amino acids; aspartic and glutamic acid as counter ions in order to improve solubility and dissolution. TMP salts were prepared by lyophilisation and characterized using FT-IR spectroscopy, proton nuclear magnetic resonance (1HNMR), Differential Scanning Calorimetry (DSC) and Thermogravimetric analysis (TGA). Both the amino acids formed salts with TMP in a 1:1 molar ratio and showed a 280 fold improvement in solubility. Investigation of the microbiological activity of the prepared salts against TMP sensitive Escherichia coli showed that the new salts not only retained antibacterial activity but also exhibited higher zone of inhibition which was attributed to improved physicochemical characters such as higher solubility and dissolution. The results are an important finding that could potentially impact on faster onset of antibacterial activity and reduced therapeutic dose when administered to patients. Studies are underway investigating the effect of ion-pairing TMP with amino acids on the permeability profile of the drug.
A Case of Fibrosing Alveolitis combined with Pulmonary Tuberculosis (1975)

A case of fibrosing alveolitis associated with pulmonary tuberculosis is presented. This is a ' case of 50-year.old woman admitted with dyspnea on exertion and fatigue for 8 months. She has clubbing fingers.
Time Series Prediction with Multilayer Perception, FIR and Elman Neural Networks (1996)

Multilayer perceptron network (MLP), FIR neural network and Elman neural network were compared in four different time series prediction tasks. Time series include load in an electric network series, fluctuations in a far-infrared laser series, numerically generated series and behaviour of sunspots series. FIR neural network was trained with temporal backpropagation learning algorithm. Results show that the efficiency of the learning algorithm is more important factor than the network model used. Elman network models load in an electric network series better than MLP network and in other prediction tasks it performs similar to MLP network. FIR network performs adequately but not as good as Elman network.
Bcl-2 and Bax Exert Opposing Effects on Ca2+ Signaling, Which Do Not Depend on Their Putative Pore-forming Region (2004)

Recent work has shown that Bcl-2 and other anti-apoptotic proteins partially deplete the endoplasmic reticulum (ER) Ca(2+) store and that this alteration of Ca(2+) signaling reduces cellular sensitivity to apoptotic stimuli. We expressed in HeLa cells Bcl-2, Bax, and Bcl-2/Bax chimeras in which the putative pore-forming domains of the two proteins (alpha 5-alpha 6) were mutually swapped, comparing the effects on Ca(2+) signaling of the two proteins and relating them to defined molecular domains. The results showed that only Bcl-2 reduces ER Ca(2+) levels and that this effect does not depend on the alpha 5-alpha 6 helices of this oncoprotein. Soon after its expression, Bax increased ER Ca(2+) loading, with ensuing potentiation of mitochondrial Ca(2+) responses. Then the cells progressed into an apoptotic phenotype (which included drastic reductions of cytosolic and mitochondrial Ca(2+) responses and alterations of organelle morphology). These results provide a coherent scenario that high-lights a primary role of Ca(2+) signals in deciphering apoptotic stimuli.
TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres (2013)

Human telomeres are maintained by the shelterin protein complex in which TRF1 and TRF2 bind directly to duplex telomeric DNA. How these proteins find telomeric sequences among a genome of billions of base pairs and how they find protein partners to form the shelterin complex remains uncertain. Using single-molecule fluorescence imaging of quantum dot-labeled TRF1 and TRF2, we study how these proteins locate TTAGGG repeats on DNA tightropes. By virtue of its basic domain TRF2 performs an extensive 1D search on nontelomeric DNA, whereas TRF1's 1D search is limited. Unlike the stable and static associations observed for other proteins at specific binding sites, TRF proteins possess reduced binding stability marked by transient binding (∼ 9-17 s) and slow 1D diffusion on specific telomeric regions. These slow diffusion constants yield activation energy barriers to sliding ∼ 2.8-3.6 κ(B)T greater than those for nontelomeric DNA. We propose that the TRF proteins use 1D sliding to find protein partners and assemble the shelterin complex, which in turn stabilizes the interaction with specific telomeric DNA. This 'tag-team proofreading' represents a more general mechanism to ensure a specific set of proteins interact with each other on long repetitive specific DNA sequences without requiring external energy sources.
Modeling CD4 + T cells dynamics in HIV-infected patients receiving repeated cycles of exogenous Interleukin 7 (2017)

International audience
Image compression with on-line and off-line learning (2004)

Images typically contain smooth regions, which are easily compressed by linear transforms, and high activity regions (edges, textures), which are harder to compress. To compress the first kind, we use a "zero" encoder that has infinite context, very low capacity, and which adapts very quickly to the content. For the second, we use an "interpolation" encoder, based on neural networks, which has high capacity, a finite-size context, and is trained off-line. The two encoders can be used separately or in combination. The zero-encoder surpasses JPEG2000 by 3.5% in overall compression, even though it is less efficient in high activity regions. Thanks to off-line training, the interpolation-encoder predicts high activity regions well, so it also matches the performance of JPEG2000, even though it does not use an arithmetic encoder and is less efficient in low activity regions. In both cases it is surprising that we match the state-of-the-art in image compression without using adaptive arithmetic encoding.
A Review of Prognostics and Health Management for Power Semiconductor Modules (2015)

&#x0D; &#x0D; &#x0D; In this paper, a review of current techniques used in the prognostics and state-of-health monitoring for power semiconductor modules is provided. Given the increasing trend in power modules having a larger share of the power electronic market, understanding their lifetime limitations is critical to improving the life-cycle cost of the power electronic product. Hence, this paper reviews common failure mechanisms in power modules and the state-of-art in predicting the lifetime of the module based on a given mission profile. Prognostics are reviewed in terms of stress- based and condition monitoring-based methods, while the potential of prognostics is presented for applications that utilize power modules.&#x0D; &#x0D; &#x0D;
Structure and Polyphenylvinylene Concentration Effect on the Photoconductivity Response from Mesostructured Silica Films (2003)

Highly ordered thin films were made by a dip-coating technique. Sodium dodecyl sulfate (SDS)-templated sol−gel films possess lamellar structure, and cetyltrimethylammonium bromide-templated sol−gel films exhibit a hexagonal structure. In this work, mesostructured films made with these surfactants were doped with polyphenylvinylene (PPV). X-ray diffraction patterns indicate that the films have the known structure. The photoconductivity technique was used to determine the charge-transport mechanism on these films. The parameters for the photovoltaic effect (φl0) and photoconductivity (φμτ) were determined from the current density versus the applied-electrical-field results. Lamellar films have bigger values of these parameters than the corresponding ones from the hexagonal films, and the conductivity is better in the former. Charge-transport parameters are quite high in the PPV-doped samples compared with the reported values in films doped with Disperse Red 1 and carbazole (SiK). KNbO3:Fe3+ photorefractive crystals are less photoconductive and photovoltaic than the PPV films, too. There is a critical polymer concentration in the SDS samples.
Distension-Induced Gastric Contraction is Attenuated in an Experimental Model of Gastric Restraint (2010)

The results show that distension-induced gastric contractility is regulated by both central nervous system and local mechanisms with the former being more substantial. Furthermore, the gastric restraint significantly attenuates gastric contractility (decreased amplitude and shortened duration of contraction) which is mediated by the efferent vagus activation. These findings have important implications for gastric motility and physiology and may improve our understanding of satiety.
Banff 2019 Meeting Report: Molecular diagnostics in solid organ transplantation–Consensus for the Banff Human Organ Transplant (B-HOT) gene panel and open source multicenter validation (2020)

This meeting report from the XV Banff conference describes the creation of a multiorgan transplant gene panel by the Banff Molecular Diagnostics Working Group (MDWG). This Banff Human Organ Transplant (B-HOT) panel is the culmination of previous work by the MDWG to identify a broadly useful gene panel based on whole transcriptome technology. A data-driven process distilled a gene list from peer-reviewed comprehensive microarray studies that discovered and validated their use in kidney, liver, heart, and lung transplant biopsies. These were supplemented by genes that define relevant cellular pathways and cell types plus 12 reference genes used for normalization. The 770 gene B-HOT panel includes the most pertinent genes related to rejection, tolerance, viral infections, and innate and adaptive immune responses. This commercially available panel uses the NanoString platform, which can quantitate transcripts from formalin-fixed paraffin-embedded samples. The B-HOT panel will facilitate multicenter collaborative clinical research using archival samples and permit the development of an open source large database of standardized analyses, thereby expediting clinical validation studies. The MDWG believes that a pathogenesis and pathway based molecular approach will be valuable for investigators and promote therapeutic decision-making and clinical trials.
Diagnosis of Helicobacter pylori infection. (1996)

A number of reliable methods are currently available for the diagnosis of Helicobacter pylori infection. These diagnostic tests can be classified into invasive methods that require endoscopy and gastric biopsy, and noninvasive methods. Invasive methods include gastric mucosal biopsies at endoscopy for bacteriologic culture, histology, and the rapid urease test. Noninvasive methods include the urea breath test and serologic tests. Each of these diagnostic tests has its advantages and disadvantages. Histologic examination remains the gold standard for diagnosis. It can also detect coccoidal forms of the bacteria and be used to assess the severity of gastritis. Culture of H pylori should be performed if antibiotic sensitivity of the organism is required. A rapid urease test is the quickest test for H pylori status. The urea breath test detects urease activity in the entire stomach, thus eliminating the possibility of a sampling error, which occurs in random gastric biopsies. Serologic tests using either ELISA or latex-agglutination methods are excellent for diagnosis of H pylori infection, but not useful for monitoring effects of therapy. Recently, the polymerase chain reaction has been applied to fixed-tissue biopsies, as well as body secretions in the diagnosis of H pylori infection.
Formation of Self-Assembled, Double-Perovskite, Ba2YNbO6Nanocolumns and Their Contribution to Flux-Pinning andJcin Nb-Doped YBa2Cu3O7-δFilms (2010)

Ba2RENbO6 (RE = rare earth elements including Y) compounds are considered new additives for superior flux-pinning in YBa2Cu3O7-δ (YBCO) films due to their excellent chemical inertness to and large lattice mismatches with YBCO. Simultaneous laser ablation of a YBCO target and a Nb metal foil attached to the surface of the target resulted in epitaxial growth of YBCO films having columnar defects comprised of self-aligned Ba2YNbO6 (BYNO) nanorods parallel to the c-axis of the film. Compared to pure YBCO, YBCO+BYNO films exhibited no Tc reduction as well as superior Jc performance with higher self- and in-field Jc by a factor of 1.5–7 and also exhibited a strong Jc peak for H∥c indicative of strong c-axis correlated flux-pinning.
Proton diffusion in the pores of silicate sol-gel glasses (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProton diffusion in the pores of silicate sol-gel glassesJohn McKiernan, Eric Simoni, Bruce Dunn, and Jeffrey I. ZinkCite this: J. Phys. Chem. 1994, 98, 3, 1006–1009Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/j100054a043https://doi.org/10.1021/j100054a043research-articleACS PublicationsRequest reuse permissionsArticle Views187Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
REMPI-TOFMS for on-line monitoring and controlling the coffee roasting process (2001)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Ralph Dorfner, Thomas Ferge, Chahan Yeretzian, Ralf Zimmermann, Antonius Kettrup; REMPI-TOFMS for on-line monitoring and controlling the coffee roasting process. AIP Conf. Proc. 22 August 2001; 584 (1): 241–246. https://doi.org/10.1063/1.1405610 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Cabergoline Treatment Promotes Myocardial Recovery in Peripartum Cardiomyopathy (2022)

In the experimental PPCM mouse model, the selective D2R agonist cabergoline prevents the onset of postpartum HF similar to bromocriptine. In PPCM patients, cabergoline treatment was safe and effective as all patients fully recovered. Cabergoline might serve as a promising alternative to bromocriptine. However, these findings are based on experimental data and a small case series and thus have to be interpreted with caution and should be validated in a larger clinical trial.
AU‐rich RNA‐binding induces changes in the quaternary structure of AUH (2008)

The human AU RNA binding protein/enoyl-Coenzyme A hydratase (AUH) is a 3-hydroxy-3-methylglutaconyl-CoA dehydratase in the leucine degradation pathway. It also possesses an RNA-binding activity to AUUU repeats, which involves no known conserved RNA-binding domains and is seemingly unrelated to the enzymatic activity. In this study, we performed mass spectrometric analyses to elucidate the oligomeric states of AUH in the presence and absence of RNA. With a short RNA (AUUU) or without RNA, AUH mainly exists as a trimer in solution. On the other hand, the AUH trimer dimerizes upon binding to one molecule of a long RNA containing 24 repeats of the AUUU motif, (AUUU)(24)A. AUH was crystallized with the long RNA. Although the RNA was disordered in the crystalline lattice, the AUH structure was determined as an asymmetric dimer of trimers with a kink in the alignment of the trimer axes, resulting in the formation of two clefts with significantly different sizes.
Closed Loop Controlled Precision Irrigation Sensor Network (2018)

A closed loop irrigation system is demonstrated that fully automates the delivery of irrigation and calculates the water requirement from satellite images. The system optimizes water delivery for 140 cells located across four hectares of land based on two independent objectives (e.g., maximizing yield and increasing water efficiency) and is continuously adapting irrigation scheduling to the local spatial–temporal variability of the vegetation across the growing season. Irrigation is controlled by a central computer that issues commands to 693 control nodes to start irrigation based on the analysis of satellite images. The control nodes are laid out to create 15 m <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\times15$ </tex-math></inline-formula> m cells and each cell can be addressed independently and can irrigate differentially. After two years of operation, this variable rate drip irrigation approach resulted in a 26% yield increase in the second year and an average increase of 16% in water use efficiency. This paper demonstrates that combining closed loop automation and advanced irrigation analytics can improve the water use efficiency and increase the yield on existing agricultural lands.
Detecting closely spaced and occluded pedestrians using specialized deep models for counting (2017)

Pedestrian detection is an important task in surveillance applications and becomes particularly challenging when pedestrians are close together or occluding one another. This paper presents a novel approach to detect pedestrians in such challenging scenarios. A deep convolutional neural network trained for counting is specialized to count one pedestrian. The feature extractor learned thereby is exploited to detect one pedestrian at a time iteratively. For the base counting model and the specialization, extensive annotation efforts are not required since only a single number at the image level is used. Use of our method on pedestrian datasets with occlusion showed an improvement in the average miss rate values as compared to other methods for handling occlusion.
Customizable Multiplex Antibody Array Immunoassays with Attomolar Sensitivities (2020)

We have developed a customizable contact printed multiplex immunoassay capable of simultaneously measuring up to five analytes with attomolar sensitivities. This enzyme-linked immunosorbent assay (ELISA) was based on spotting different antibodies in a circular pattern at the bottom of a microtiter plate well. Unlike traditional antibody printing for ELISA that prints a capture antibody specific to a target of interest, in this ELISA we printed unique "anchor" antibodies at the well surface, each having a high affinity for a specific peptide target. By coupling each peptide to a unique assay capture antibody, this array of anchor antibodies enabled a customizable contact printed multiplex immunoassay workflow. As a proof of concept, we developed a 5-plex assay measuring interleukin 5 (IL-5), interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 22 (IL-22), and tumor necrosis factor alpha (TNF-α). Measurements of these five analytes in serum and plasma correlated well between the method utilizing the anchor antibodies and peptides and the traditional capture antibody printing approach, with <i>r</i><sup>2</sup> values of 0.99, 0.93, 0.99, 0.96, and 0.75 for IL-5, IL-6, IL-10, IL-22, and TNFα, respectively. This approach makes customizable multiplex ultrasensitive ELISA available to laboratories without access to the precision printing instrumentation and will be useful for antibody screening, custom assay development, biomarker detection, and protein profiling for diagnostic applications.
ChemInform Abstract: Total Synthesis of Fluorinated Analogues of Inositol and Inositol 1,4, 5‐Triphosphate. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ENERGY DISSIPATION CHARACTERISTICS OF CLUSTERED RUBBER CYLINDERS. FINAL REPORT (1989)

Crash cushions have proven to be one of the most cost-beneficial life-saving devices on our nation's highways. However, all of the widely used designs utilize sacrificial, energy-absorbing materials. A significant maintenance effort, with associated costs, is necessary to restore these cushions after an impact. The purpose of the present research was to develop a low-maintenance crash cushion utilizing reusable rubber elements. An extensive laboratory study was made to evaluate various rubber compounds and shapes in terms of energy-absorbing characteristics, durability, sensitivity to the environment, and cost. Of the materials examined, it was found that a natural rubber--20% EPDM blend--offered the greatest promise. A full-scale prototype crash cushion was then constructed consisting of a cluster of hollow circular cylinders formed from the above material. The prototype was subjected to a series of vehicular crash tests. Due to unexpected failures in the rubber cylinders, it was not possible to completely qualify the cushion in terms of recommended impact performance criteria. The failures were attributed to the mandrell wrapping process by which the cylinders were constructed. It was concluded that these problems could be solved by constructing the cylinders from a compression mold process. It was further concluded that a low-maintenance rubber crash cushion is feasible and could reduce life-cycle costs in excess of 60 percent for high accident locations. Further research is recommended to complete the work reported herein.
Intra super-channel nonlinearity mitigation in uniform and non-uniform links employing pre-dispersed spectral inversion (2015)

Pre-dispersed spectral inversion enables ~2.7dB, ~2.3dB, and ~1.6dB improvements for SSMF, LAPSCF, and TWC based uniform fiber links, respectively. Non-uniform links employing 50% mixing (worst-case) enable ~1.3dB and ~0.5dB improvements for SSMF/LAPSCF and SSMF/TWC fiber-mixes.
Photosensitized inactivation of Plasmodium falciparum in human red cells by phthalocyanines (1996)

Photodynamic treatment with Pc 4 could make red cell concentrate not only virally safe for transfusion but also safe with respect to transmitting malaria.