gebhart/patrepeval huggingface dataset:
Listeria monocytogenes Subgroups IIIA, IIIB, and IIIC Delineate Genetically Distinct Populations with Varied Pathogenic Potential (2006)

Listeria monocytogenes lineage III strains belonging to subgroups IIIA (n = 8), IIIB (n = 5), and IIIC (n = 6) were examined along with other known serotype strains (n = 11) by PCR and Southern hybridization using several recently described species-, virulence-, and serotype-specific primers and probes. The virulence of seven representative lineage III strains was then evaluated in mice via the intraperitoneal route. The results suggest that subgroup IIIA consists of typical rhamnose-positive avirulent serotype 4a and virulent serotype 4c strains, subgroup IIIC consists of atypical rhamnose-negative virulent serotype 4c strains, and subgroup IIIB consists of atypical rhamnose-negative virulent non-serotype 4a and non-serotype 4c strains, some of which may be related to serotype 7. It is possible that subgroup IIIB (including serotype 7) may represent a novel subspecies within L. monocytogenes.
Draft Genome Sequence of Enterococcus mundtii SCPM-O-B-8398 (E28), Isolated from Fermented Milk in the Moscow Region, Russian Federation (2021)

We report the draft genome sequence of the bacteriocin-producing Enterococcus mundtii strain SCPM-O-B-8398 (E28), which was isolated from fermented milk in the Moscow region, Russian Federation.
Two-photon absorption properties of multipolar triarylamino/tosylamido 1,1,4,4-tetracyanobutadienes (2021)

The synthesis and characterization of four new tetracyanobutadiene (TCBD) derivatives (1, 3c and 4b-c) incorporating tosylamido and 4-triphenylamino moieties are reported. Along with those of five closely related or differently branched TCBDs derivatives (2, 3a-b, 4c and 5), their linear and (third-order) nonlinear optical properties were investigated by electronic absorption spectroscopy and Z-scan measurements. Among these compounds, the tri-branched compounds 3c and 5 are the most active two-photon absorbers, with effective cross-sections of 275 and 350 GM at 900 nm, respectively. These properties are briefly discussed with the help of DFT calculations, focussing on structural and electronic factors, and contextualized with results obtained previously for related compounds.
Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1‐Substituted Tetrahydroisoquinolines (2014)

The syntheses and antiproliferative activities of novel substituted tetrahydroisoquinoline derivatives and their sulfamates are discussed. Biasing of conformational populations through substitution on the tetrahydroisoquinoline core at C1 and C3 has a profound effect on the antiproliferative activity against various cancer cell lines. The C3 methyl-substituted sulfamate (±)-7-methoxy-2-(3-methoxybenzyl)-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline (6 b), for example, was found to be ∼10-fold more potent than the corresponding non-methylated compound 7-methoxy-2-(3-methoxybenzyl)-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline (4 b) against DU-145 prostate cancer cells (GI50 values: 220 nM and 2.1 μM, respectively). Such compounds were also found to be active against a drug-resistant MCF breast cancer cell line. The position and nature of substitution of the N-benzyl group in the C3-substituted series was found to have a significant effect on activity. Whereas C1 methylation has little effect on activity, introduction of C1 phenyl and C3-gem-dimethyl substituents greatly decreases antiproliferative activity. The ability of these compounds to inhibit microtubule polymerisation and to bind tubulin in a competitive manner versus colchicine confirms the mechanism of action. The therapeutic potential of a representative compound was confirmed in an in vivo multiple myeloma xenograft study.
Simple Criterion on Colloid Formation in SiO2 Glasses by Ion Implantation (1993)

A simple criterion as a first approximation to predict the formation of elementary colloids of implants in SiO 2 glasses by ion implantation has been proposed. The criterion predicts that colloid formation occurs when free energy of formation of oxides of implants is greater than that of SiO 2 at ∼3000 K, which corresponds to the fictive temperature of implanted layers. The prediction is compared with observations reported so far.
Frequency-Domain Equalization Incorporated with Frequency-Domain Redundancy for OFDM Systems (2006)

This paper proposes a frequency-domain equalizer (FEQ) which utilizes not only guard interval but also redundancy in the frequency domain to eliminate inter-symbol and inter-carrier interferences. The proposed FEQ employs the hybrid criterion, i.e., the zero-forcing (ZF) criterion for compensating desired subcarriers and the minimum mean square error (MMSE) criterion for suppressing interference. The proposed Hybrid-FEQ achieves a good equalization performance, because it can suppress the noise enhancement caused by the ZF criterion with relatively small computational complexity exploiting soft-decision forward error correction (FEC). In this paper, we show its equalization performance and complexity compared with the conventional FEQs.
Model predictive control (MPC) algorithm for tip-jet reaction drive systems (2009)

Modern technologies coupled with advanced research have allowed model predictive control (MPC) to be applied to new and often experimental systems. The purpose of this research is to develop a model predictive control algorithm for tip-jet reaction drive system. This system's faster dynamics require an extremely short sampling rate, on the order of 20ms, and its slower dynamics require a longer prediction horizon. This coupled with the fact that the tip-jet reaction drive system has multiple control inputs makes the integration of an online MPC algorithm challenging. In order to apply a model predictive control to the system in question, an algorithm is proposed that combines multiplexed inputs and a feasible cooperative MPC algorithm.&#13;\nIn the proposed algorithm, it is hypothesized that the computational burden will be reduced from approximately Hp(Nu + Nx)3 to pHp(Nx+1)3 while maintaining control performance similar to that of a centralized MPC algorithm. To capture the performance capability of the proposed controller, a comparison its performance to that of a multivariable proportional-integral (PI) controller and a centralized MPC is executed. The sensitivity of the proposed MPC to various design variables is also explored. In terms of bandwidth, interactions, and disturbance rejection, the proposed MPC was very similar to that of a centralized MPC or PI controller. Additionally in regards to sensitivity to modeling error, there is not a noticeable difference between the two MPC controllers. Although the constraints are handled adequately for the proposed controller, adjustments can be made in the design and sizing process to improve the constraint handling, so that it is more comparable to that of the centralized MPC. Given these observations, the hypothesis of the dissertation has been confirmed. The proposed MPC does in fact reduce computational burden while maintaining close to centralized MPC performance.
ChemInform Abstract: PARTIAL ′NITROSYLATION′ OF DICARBONYL(η‐CYCLOPENTADIENYL)COBALT (1977)

Abstract Die partielle Nitrosylierung des Titelkomplexes (I) gelingt bei der Umsetzung mit NO bei tiefen Temperaturen oder mit N‐Alkyl‐N‐nitrosoharnstoff in siedendem Benzol.
Redox Behavior of Cyclo[6]pyrrole in the Formation of a Uranyl Complex (2007)

A uranyl complex, the first metal complex to be formed from the cyclo[n]pyrrole series of expanded porphyrins, is formed when cyclo[6]pyrrole is treated with the uranyl cation under aerobic conditions. Spectroscopic, spectroelectrochemical, and electron spin resonance data of this species are consistent with the ligand in the complex being oxidized to an antiaromatic form.
Impact of psychological stress on irritable bowel syndrome (2014)

Psychological stress is an important factor for the development of irritable bowel syndrome (IBS). More and more clinical and experimental evidence showed that IBS is a combination of irritable bowel and irritable brain. In the present review we discuss the potential role of psychological stress in the pathogenesis of IBS and provide comprehensive approaches in clinical treatment. Evidence from clinical and experimental studies showed that psychological stresses have marked impact on intestinal sensitivity, motility, secretion and permeability, and the underlying mechanism has a close correlation with mucosal immune activation, alterations in central nervous system, peripheral neurons and gastrointestinal microbiota. Stress-induced alterations in neuro-endocrine-immune pathways acts on the gut-brain axis and microbiota-gut-brain axis, and cause symptom flare-ups or exaggeration in IBS. IBS is a stress-sensitive disorder, therefore, the treatment of IBS should focus on managing stress and stress-induced responses. Now, non-pharmacological approaches and pharmacological strategies that target on stress-related alterations, such as antidepressants, antipsychotics, miscellaneous agents, 5-HT synthesis inhibitors, selective 5-HT reuptake inhibitors, and specific 5-HT receptor antagonists or agonists have shown a critical role in IBS management. A integrative approach for IBS management is a necessary.
A 65 nm Single-Chip Application and Dual-Mode Baseband Processor With Partial Clock Activation and IP-MMU (2009)

Supporting both WCDMA with HSDPA and GSM/GPRS/EDGE, the 9.3 times 9.3 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> SoC fabricated in triple-Vth 65 nm CMOS, has three CPU cores and 20 separate power domains. Unused power domains can be powered down to reduce the leakage power. Partial clock activation scheme especially focused on music playback scene dynamically stops a PLL and clock trees when not necessary and reduces power consumption from 33.6 mW to 19.6 mW. IP-MMU translates virtual address to physical address for 18 hardware-IPs and virtual address space can be allocated when necessary and can be freed after its operation, reducing external memory by 43 MB. Video performance of D1 (720 times 520) size with 30 frames per second for MPEG/AVC decoding and encoding can be achieved under mixed virtual and physical address usage.
Lesions to the Fronto-Parietal Network Impact Alpha-Band Phase Synchrony and Cognitive Control (2018)

Long-range phase synchrony in the α-oscillation band (near 10 Hz) has been proposed to facilitate information integration across anatomically segregated regions. Which areas may top-down regulate such cross-regional integration is largely unknown. We previously found that the moment-to-moment strength of high-α band (10-12 Hz) phase synchrony co-varies with activity in a fronto-parietal (FP) network. This network is critical for adaptive cognitive control functions such as cognitive flexibility required during set-shifting. Using electroencephalography (EEG) in 23 patients with focal frontal lobe lesions (resected tumors), we tested the hypothesis that the FP network is necessary for modulation of high-α band phase synchrony. Global phase-synchrony was measured using an adaptation of the phase-locking value (PLV) in a sliding window procedure, which allowed for measurement of changes in EEG-based resting-state functional connectivity across time. As hypothesized, the temporal modulation (range and standard deviation) of high-α phase synchrony was reduced as a function of FP network lesion extent, mostly due to dorsolateral prefrontal cortex (dlPFC) lesions. Furthermore, patients with dlPFC lesions exhibited reduced cognitive flexibility as measured by the Trail-Making Test (set-shifting). Our findings provide evidence that the FP network is necessary for modulatory control of high-α band long-range phase synchrony, and linked to cognitive flexibility.
Relevance of Platelet-independent Effects of Aspirin to Its Salutary Effect in Atherosclerosis-related Events (2005)

There is a close inter-relationship between oxidative stress, coagulation, inflammation, and smooth muscle cell growth as key components of atherosclerosis (Fig. 1). As an analgesic and anti-pyretic, aspirin has been in use for over a century. It acetylates the COX enzyme, irreversibly inhibiting the formation of prostaglandin. Its action on platelet TxA2 has highlighted its role as an anti-thrombotic agent in cardiovascular patients. Over the last two decades, unique anti-inflammatory properties of aspirin not shared by other non-steroidals have been discovered. Aspirin biotransforms into salicylate, which has diverse but potent anti-inflammatory properties. As we strive to better understand the concepts of atherogenesis, chronic inflammation, oxidative stress, and endothelial activation, these novel effects of aspirin provide new insights as to how this wonder drug works. These effects of aspirin alter many, if not all, components of the atherogenesis cascade shown in Fig. 1.
System and method for islanding detection and prevention in distributed generation (2023)

A method for detecting and preventing islanding includes issuing a command to an inverter connected to a power source, where the inverter is coupled to a power grid and supplies power to the power grid, the command causes a frequency of a waveform output by the inverter to vary, and the frequency of the waveform output by the inverter is a command frequency, determining that a amount of change of the command frequency is a constant value for a predetermined amount of time, removing the power supplied by the inverter from the power grid, and determining whether the power grid is valid.
Evanescent Field Atom Optics Using Micro-Tapered Fibers (2006)

We present initial results obtained using an evanescent field of a tapered optical fibre for trapping and guiding cold, neutral atoms. Losses through the fibre are monitored in order to detect atom-light coupling.
Synthesis and reactivity of two monomeric tungsten(IV) phenoxide complexes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and reactivity of two monomeric tungsten(IV) phenoxide complexesMark L. Listemann, Richard R. Schrock, John C. Dewan, and Richard M. KolodziejCite this: Inorg. Chem. 1988, 27, 2, 264–271Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/ic00275a010https://doi.org/10.1021/ic00275a010research-articleACS PublicationsRequest reuse permissionsArticle Views489Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Squalene-Adenosine Nanoparticles: Ligands of Adenosine Receptors or Adenosine Prodrug? (2019)

Adenosine receptors (ARs) represent key drug targets in many human pathologies, including cardiovascular, neurologic, and inflammatory diseases. To overcome the very rapid metabolization of adenosine, metabolically stable AR agonists and antagonists were developed. However, few of these molecules have reached the market due to efficacy and safety issues. Conjugation of adenosine to squalene to form squalene-adenosine (SQAd) nanoparticles (NPs) dramatically improved the pharmacological efficacy of adenosine, especially for neuroprotection in stroke and spinal cord injury. However, the mechanism by which SQAd NPs displayed therapeutic activity remained totally unknown. In the present study, two hypotheses were discussed: 1) SQAd bioconjugates, which constitute the NP building blocks, act directly as AR ligands; or 2) adenosine, once released from intracellularly processed SQAd NPs, interacts with these receptors. The first hypothesis was rejected, using radioligand displacement assays, as no binding to human ARs was detected, up to 100 <i>µ</i>M SQAd, in the presence of plasma. Hence, the second hypothesis was examined. SQAd NPs uptake by HepG2 cells, which was followed using radioactive and fluorescence tagging, was found to be independent of equilibrative nucleoside transporters but rather mediated by low-density lipoprotein receptors. Interestingly, it was observed that after cell internalization, SQAd NPs operated as an intracellular reservoir of adenosine, followed by a sustained release of the nucleoside in the extracellular medium. This resulted in a final paracrine-like activation of the AR pathway, evidenced by fluctuations of the second messenger cAMP. This deeper understanding of the SQAd NPs mechanism of action provides a strong rational for extending the pharmaceutical use of this nanoformulation.
An Intuitive Way to Understand Mutual Coupling Effects in Antenna Arrays Using the Poynting Streamline Method (2018)

The flow of energy around array antenna in receiving mode can be modeled by generating streamlines of the Poynting vector field. From the streamlines that terminate on the array element loads, a geometrical shape can be assigned to the effective area of the array. These concepts provide an intuitive tool for understanding mutual coupling effects in antenna arrays. The decrease in directivity associated with mutual coupling effects, the so-called element-gain paradox, can be explained by the overlap of the element effective area shapes. The critical element spacing for the element-gain paradox effect can be predicted from the effective area shape for a single isolated array element. Antenna design for minimizing mutual coupling, which is of interest in multiple input multiple output communications systems, magnetic resonance imaging arrays, astronomical arrays, and other applications, can be guided by analysing the effective area shape for a single isolated array element.
Effects of porcine somatotropin and dietary phosphorus on growth and bone criteria in gilts (1991)

One hundred-eight gilts with an average initial wt of 129 lb were utilized to determine the effects of porcine somatotropin (pST) and dietary phosphorus on growth performance and bone mineralization and mechanical properties during the finishing phase (129 to 230 lb) and a 35 d post-finishing phase. Gilts were injected daily with placebo (control) or 4 mg pST and fed diets containing .4, .8, or 1.2% P during the finishing phase. Administration of pST improved F/G 18%, increased ADG 8%, and decreased daily feed intake 9%. There was a quadratic response to P, because gilts receiving the .8% P diet were more efficient than gilts fed either .4 or 1.2% P, regardless of whether they received pST or placebo. When pen wt reached 230 lb, half of the gilts were slaughtered and 1st rib, femur, and 3rd and 4th metacarpals were collected. First rib ash content increased linearly as the level of dietary P increased; however, pST administration had no effect on ash content. There was a pST x P interaction for rib bending moment, stress, and modulus of elasticity. Bone strength was maximized for control gilts at .8% P, whereas bone strength continued to increase as the level of dietary P was increased for pST-treated gilts. The remaining 54 gilts were individually fed 4 lb/d of a common diet for a 35 d post-finishing phase and then slaughtered. Gilts that received higher P levels in the finishing phase had higher rib ash content at the end of the post-finishing phase. There was a pST x P interaction for treatment combination received in the finishing phase on rib and femur bending moment post-finishing. Bone strength for pST-treated gilts receiving the .8 or 1.2% P diet in the finishing phased increased to levels exceeding those of control gilts by the end of the post-finishing phase, regardless of dietary P level control gilts were fed in the finishing phase. These data indicate that gilts administered pST in the finishing phase do not have higher Ca and P requirements than non-pST treated gilts to maximize growth performance. However, pST-treated gilts do have higher requirements for Ca and P than non-pST treated gilts to attain comparable bone strength in the finishing phase. Gilts receiving pST in the finishing phase demonstrate compensatory mineralization in the post-finishing phase, because bone strength increases to equal or exceed that of control gilts fed similar P levels.; Swine Day,
Skin Photoaging (2015)

This book focuses on skin photoaging, the premature aging of skin due to environmental effects such as exposure to UV radiation from the Sun. Slowing the aging process and rejuvenation have been one of the major goals of medicine and are in high demand as consumers seek agents or treatments that can prevent or reverse age-associated changes in the skin. Skin Photoaging reviews the compounds and modalities that have been shown (or have potential) to improve the appearance of prematurely aged skin.
miRNA malfunction causes spinal motor neuron disease (2010)

Defective RNA metabolism is an emerging mechanism involved in ALS pathogenesis and possibly in other neurodegenerative disorders. Here, we show that microRNA (miRNA) activity is essential for long-term survival of postmitotic spinal motor neurons (SMNs) in vivo. Thus, mice that do not process miRNA in SMNs exhibit hallmarks of spinal muscular atrophy (SMA), including sclerosis of the spinal cord ventral horns, aberrant end plate architecture, and myofiber atrophy with signs of denervation. Furthermore, a neurofilament heavy subunit previously implicated in motor neuron degeneration is specifically up-regulated in miRNA-deficient SMNs. We demonstrate that the heavy neurofilament subunit is a target of miR-9, a miRNA that is specifically down-regulated in a genetic model of SMA. These data provide evidence for miRNA function in SMN diseases and emphasize the potential role of miR-9-based regulatory mechanisms in adult neurons and neurodegenerative states.
ChemInform Abstract: Lithium/Ammonia Cleavage of the N‐N Bond in N‐(Methoxycarbonyl)‐ and N‐ Acetylhydrazines. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
How Nanoscience Translates into Technology: The Case of Self-Assembled Monolayers, Electron-Beam Writing, and Carbon Nanomembranes (2013)

One of the great quests in nanotechnology is to translate nanoprecision materials science into practical manufacturing processes. The paper by Angelova et al. in this issue of ACS Nano, which discusses the production of functional carbon-based membranes with a thickness of 0.5 to 3 nm, provides instructive insight into how researchers are pulling together complementary strands from a quarter century of nanoscience research to develop novel, hybrid processing schemes. In this Perspective, we reflect on the progress that is taking place in the two principal component technologies combined in this scheme, namely, (i) control of self-assembled monolayers, including their detailed atomic structures, and (ii) electron-induced manipulation and processing of molecular layers, as well as considering (iii) remaining challenges for thin membrane production in the future.