gebhart/patrepeval huggingface dataset:
Response of Wasmannia auropunctata (Hymenoptera: Formicidae) to Water-Soaked Imported Fire Ant Baits (2022)

La pequeña hormiga de fuego, Wasmannia auropunctata (Roger) (Hymenoptera: Formicidae), es una hormiga invasora urticante que puede establecer poblaciones dominantes extremadamente grandes en regiones tropicales y subtropicales. En Florida, está bien establecida en el sur y el centro de la Florida con un límite norte hasta el condado de Marion, Florida, EE. UU. Sin embargo, entre el 2018 y 2019 se descubrieron poblaciones que hibernan más al norte, en Gainesville, Florida. Existe la necesidad de desarrollar opciones de manejo efectivas adecuadas para los usos del sitio de estas infestaciones descubiertas recientemente. La mayoría de los cebos comerciales importados para hormigas de fuego están formulados con grano de maíz como portador que cuando se expone a la humedad, se cree que compromete la eficacia del cebo. Debido al clima húmedo y lluvioso del verano en esta región, el objetivo de este estudio fue determinar la aceptación y eficacia de los cebos para hormigas empapados en agua sobre W. auropunctata, algunos de los cuales tenían supuesta resistencia a la humedad. Las pruebas de aceptación de cebos realizadas en el campo con cebos secos determinaron que los cebos que contenían los ingredientes activos spinosad y pyriproxyfen fueron mal aceptados, mientras que W. auropunctata aceptó cebos secos y húmedos que contenían hidrametilnon, metaflumizona, indoxacarb y abamectina. Las colonias de laboratorio a las que se les dio acceso a cebos secos o húmedos exhibieron disminuciones significativas de obreras, crías y reinas y con varias eliminadas. Los resultados de este estudio indicaron que los cebos para hormigas de fuego importados empapados en agua podrían controlar W. auropunctata, y la exposición a la humedad no hizo que los cebos se volvieran desagradables. Sin embargo, estos resultados deben validarse en condiciones de campo, donde la precipitación puede reducir la accesibilidad de los cebos para las hormigas en busca de alimento.
Dynamics and Topological Constraints (2019)

This accessible new text introduces the theoretical concepts and tools essential for graduate-level courses on the physics of materials in condensed matter physics, physical chemistry, materials science and engineering, and chemical engineering. Topics covered range from fundamentals such as crystal periodicity and symmetry, and derivation of single-particle equations, to modern additions including graphene, two-dimensional solids, carbon nanotubes, topological states, and Hall physics. Advanced topics such as phonon interactions with phonons, photons and electrons, and magnetism, are presented in an accessible way, and a set of appendices reviewing crucial fundamental physics and mathematical tools makes this text suitable for students from a range of backgrounds. Students will benefit from the emphasis on translating theory into practice, with worked examples explaining experimental observations, applications illustrating how theoretical concepts can be applied to real research problems, and 242 informative full color illustrations. End-of chapter exercises are included for homework and self-study, with solutions and lecture slides for instructors available online.
Site‐Selective Ser‐Hydrolase Labelling with a Luminescent Organometallic NCN–Platinum Complex (2010)

Abstract The synthesis, spectroscopic properties and protein‐binding studies of a novel luminescent organometallic NCN–platinum complex are described. The luminescent organometallic complex was linked to a serine hydrolase reactive phosphonate group by means of click chemistry, and was exploited in serine hydrolase specific‐binding studies using gel electrophoresis. The NCN–platinum protein label was found to be a robust dye with absorbance and emission maxima between 374–380 and 482–493 nm, respectively, and quantum yields between 0.04 and 0.15.
Passivity–preserving interpolation‐based parameterized model order reduction of PEEC models based on scattered grids (2010)

Abstract The increasing operating frequencies and decreasing IC feature size call for 3‐D electromagnetic (EM) methods, such as the Partial Element Equivalent Circuit (PEEC) method, as necessary tools for the analysis and design of high‐speed systems. Very large systems of equations are often generated by 3‐D EM methods and model order reduction (MOR) techniques are commonly used to reduce such a high model complexity. A typical design process includes optimization and design space exploration, and hence requires multiple simulations for different design parameter values. Traditional MOR techniques perform model reduction only with respect to frequency and such design activities call for parameterized MOR (PMOR) methods that can reduce large systems of equations with respect to frequency and other design parameters of the circuit, such as geometrical layout or substrate characteristics. We present a novel PMOR technique applicable to the PEEC method that provides parametric reduced order models, stable and passive by construction, over a user defined design space. We treat the construction of parametric reduced order models on scattered design space grids. Pertinent numerical examples validate the proposed approach. Copyright © 2010 John Wiley &amp; Sons, Ltd.
A‐80426, a potent and selective α2‐adrenoceptor antagonist with serotonin uptake‐blocking activity and putative antidepressant‐like effects: II. Pharmacology profile (1995)

Abstract A‐80426 N ‐[2‐(benzofuran‐6‐yl)ethyl]‐ N ‐[(R)−( + (‐5‐methoxy‐1,2,3,4‐tetrahydronaphthalen‐1‐yl methyl]‐ N ‐methylamine) is a compound that combines in vitro selective inhibition of serotonin synaptosomal uptake and α 2 ‐adrenoceptor antagonism. In the present studies, A‐80426 was evaluated in vivo for its ability to block serotonin uptake and α 2 ‐adrenoceptors. The antidepressant potential of the compound was also assessed. In rats, A‐80426 significantly reduced p ‐chloroamphetamine (PCA)‐induced hyperactivity, a measure of the in vivo blockade of serotonin uptake, after acute (ED 50 = 13 μmoles/kg, po) and chronic (14 day) (ED 50 = 4.1 μmoles/kg, po) dosing. At doses of 6.7 and 22 μmoles/kg, po, A‐80426 was effective in this test procedure for at least 12 h following administration. Doses of 6.7 to 224 μmoles/kg, ip, of A‐80426, however, failed to block hypothermia and hypoactivity produced by the α 2 ‐adrenoceptor agonist clonidine, and doses of 100 and 300 μmoles/kg, po, were required to blocked clonidine‐induced mydriasis. Thus, the in vitro α 2 receptor binding and blocking effects observed with A‐80426 did not translate into the in vivo situation. A‐80426 was able to reverse the step‐down passive avoidance deficit seen in olfactory bulbectomized rats (ED 70 = 7.1 μmoles/kg, po), a finding suggesting that the compound has antidepressant potential. The compound was, however, inactive in the tail suspension and forced swim tests of antidepressant activity in mice at doses up to 72 μmoles/kg, ip. In contrast, fluoxetine was active in all three paradigms. Despite its favorable in vitro profile, A‐80426 is not an effective α 2 blocker in vivo and is inactive in the behavioral dispair models of depression. It is unlikely that A‐80426 would have antidepressant activity equivalent to existing selective serotonin reuptake inhibitors. α 2 blockade as a potential approach to eliciting antidepressant activity is discussed. © 1995 Wiley‐Liss, Inc.
Circulating RNAs as biomarkers in Epstein-Barr virus-associated nasopharyngeal carcinoma (2016)

Nasopharyngeal carcinoma (NPC) is an aggressive tumour associated with Epstein-Barr virus (EBV), which has a poor prognosis when detected late. Easy methods for detecting NPC at earlier stages are highly needed. Host and viral miRNAs are perturbed in NPC, a fraction of which are included in extracellular vesicles and/or in ribonucleoprotein complexes that enter into the circulation. Measuring circulating miRNAs may provide a robust and direct insight of the oncogenic process. Here we analysed whether host and viral circulating miRNA fingerprints may reflect tumour burden and behaviour. Defined circulating microRNAs were analysed from total serum and plasma (NPC, non-NPC patients and healthy controls). Selected NPC sera and plasma were fractionated by size-exclusion chromatography into extracellular vesicle and lipoprotein fractions. Exosome-like vesicles released from EBV-infected NPC were characterized by western blot and transmission electron microscopy. Deep RNA sequencing (RNAseq) was done for NPC cell lines, exosomes and selected sera. EBV DNA load was measured as well. Viral miRNA (mirBART7, 9, 13), host miRNA (miR16, 21, 155) and small RNAs (EBER1 and vaultRNA) were detected by stemloop reverse transcription-polymerase chain reaction (RT-PCR). We detected viral miRNAs in NPC sera and plasma which levels seem to increase with TNM stage despite absence of detectable EBV DNA in some. EBER1 RNA was absent in virtually all NPC sera and plasma, despite high levels in NPC tissues. Cellular miR155, which expression is induced by EBV-LMP1, was significantly elevated in NPC when compared to controls. Fractionation from NPC sera and plasma revealed that miR155 and vault RNA are selectively enriched in extracellular vesicles, whereas viral miRNAs are more randomly distributed. The pattern of tetraspanin (CD63, CD81) protein expression is heterogeneous in NPC patients compared to healthy controls. Further, RNAseq and RT-PCR analysis are being performed to determine the diagnostic potential of circulating miRNAs for NPC.
Solutions in closed form for a double-spiral heat exchanger (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolutions in closed form for a double-spiral heat exchangerMatthew J. Targett, William B. Retallick, and Stuart W. ChurchillCite this: Ind. Eng. Chem. Res. 1992, 31, 3, 658–669Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/ie00003a003https://doi.org/10.1021/ie00003a003research-articleACS PublicationsRequest reuse permissionsArticle Views217Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Elucidating the Mechanism of Anoctamin 5 Deficiency with a Novel KO Mouse Model (P5.092) (2014)

OBJECTIVE: To determine if Anoctamin 5 is necessary for normal muscle membrane repair function using an ANO5 KO mouse model. BACKGROUND: Limb girdle muscular dystrophy type 2L (LGMD2L) is caused by mutations in the anoctamin 5 (ANO5) gene. ANO5 encodes a predicted 107 kDa protein containing 8 transmembrane domains and is part of a family that encodes at least 2 calcium-activated chloride channels; however the exact function of ANO5 has yet to be determined. The clinical phenotype overlaps with that of LGMD2B patients having mutations in dysferlin, a gene required for membrane repair. DESIGN/METHODS: We have developed an ANO5 deficient mouse model for LGMD2L to study disease pathophysiology with the ultimate goal of considering a gene therapy approach to treat patients with ANO5 deficiencies. After breeding to homozygosity, we tested 4-month-old KO mice for defects in membrane repair as well as force deficits. We also generated an AAV vector containing the ANO5 gene to study expression and provide proof of principle for therapy. RESULTS: Preliminary characterization studies in the KO model have demonstrated a reduction in several muscle proteins that may be associated with AN05 and identified histopathological changes. We have noted a significant inability to reseal the sarcolemmal membrane after laser injury of ANO5 KO mice muscle. While the specific force in ANO5 KO mice was no different than wild type, we did find a significant decrease in force following repetitive eccentric contractions. CONCLUSIONS: The ANO5 KO mouse is novel and represents an important animal model for study of LGMD2L. It is the ideal model to develop proof of principle for gene replacement therapy or pharmacologic approaches. The model permits studies defining ANO5 function, a critical parameter for therapeutic intervention. Study Supported by: Funding to LRK provided by TRINCH and OSU. Special thanks to Viral Vector Core and the Transgenic Core at The Research Institute at Nationwide Children’s Hospital
The Effect of Distance Between Fuel and Oxidizer Nozzles on NOx Emission From High Temperature Air Combustion (2011)

This study describes NOx emission characteristics of a high temperature air combustion furnace operating with parallel jet burner system. In the parallel jet burner system, fuel nozzles are separated with a distance from an oxidizer nozzle. Objectives of this study are to clarify the effect of the distance between the fuel nozzle and the oxidizer nozzle on NOx emission. The emission index of NOx (EINOx) decreases with the increase in the distance. This is due to the dilution through entrainment of burned gas. A scaling concept is proposed to assess the dilution effect on the NOx emission. Scaling parameters employed here are the global residence time of fuel and the flame temperature evaluated on a modified flamelet model in which the dilution effect is included. The overall EINOx production rate is scaled with the flame temperature. This scaling indicates the importance of the distance between the nozzles for NOx emission.
Characterization of Genetic Variability of Venezuelan Equine Encephalitis Viruses (2016)

Venezuelan equine encephalitis virus (VEEV) is a mosquito-borne alphavirus that has caused large outbreaks of severe illness in both horses and humans. New approaches are needed to rapidly infer the origin of a newly discovered VEEV strain, estimate its equine amplification and resultant epidemic potential, and predict human virulence phenotype. We performed whole genome single nucleotide polymorphism (SNP) analysis of all available VEE antigenic complex genomes, verified that a SNP-based phylogeny accurately captured the features of a phylogenetic tree based on multiple sequence alignment, and developed a high resolution genome-wide SNP microarray. We used the microarray to analyze a broad panel of VEEV isolates, found excellent concordance between array- and sequence-based SNP calls, genotyped unsequenced isolates, and placed them on a phylogeny with sequenced genomes. The microarray successfully genotyped VEEV directly from tissue samples of an infected mouse, bypassing the need for viral isolation, culture and genomic sequencing. Finally, we identified genomic variants associated with serotypes and host species, revealing a complex relationship between genotype and phenotype.
Cell Line–Specific Network Models of ER+ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations (2021)

Durable control of invasive solid tumors necessitates identifying therapeutic resistance mechanisms and effective drug combinations. In this work, we used a network-based mathematical model to identify sensitivity regulators and drug combinations for the PI3Kα inhibitor alpelisib in estrogen receptor positive (ER<sup>+</sup>) <i>PIK3CA</i>-mutant breast cancer. The model-predicted efficacious combination of alpelisib and BH3 mimetics, for example, MCL1 inhibitors, was experimentally validated in ER<sup>+</sup> breast cancer cell lines. Consistent with the model, FOXO3 downregulation reduced sensitivity to alpelisib, revealing a novel potential resistance mechanism. Cell line-specific sensitivity to combinations of alpelisib and BH3 mimetics depended on which BCL2 family members were highly expressed. On the basis of these results, newly developed cell line-specific network models were able to recapitulate the observed differential response to alpelisib and BH3 mimetics. This approach illustrates how network-based mathematical models can contribute to overcoming the challenge of cancer drug resistance. SIGNIFICANCE: Network-based mathematical models of oncogenic signaling and experimental validation of its predictions can identify resistance mechanisms for targeted therapies, as this study demonstrates for PI3Kα-specific inhibitors in breast cancer.
Clinical Application and Challenges of Blood Glucose Measurement Technology for Self-Monitoring (2008)

Patients and many physicians believe that modern blood glucose meters provide reliable results under all circumstances. The aim of this (mini-)review is to critically review a number of aspects that should be taken into account for successful self-monitoring of blood glucose (SMBG). Usage and practical knowledge of patients about the optimal knowledge of SMBG appear to be lower than one expects. A number of factors like coding and calibration have an impact on the reliability of the measurement. Unfortunately, we have no standard procedure to evaluate the quality of the glucose measurement by the meters. In practice, SMBG is more than simply the glucose measurement; it involves many steps that also have a critical impact on the final outcome. We will also highlight that the digital number provided at the end of this diagnostics procedure is of no help per se; it requires a translation in an adequate therapeutic action. Most of the aspects mentioned have not gained thorough scientific interest in the last years. Also, in view of the economic relevance of SMBG (billions are spend each and every year) SMBG and the factors that have an impact on the reliability of the measurement should receive more attention by academia.
Abstract 20724: Matrix-Promoted Efficient Cardiac Differentiation of Human iPS and ES Cells (2010)

Efficient and reproducible approaches for differentiating human iPS and ES cells to cardiomyocytes (CMs) are needed for research and potential clinical applications. The purpose of this study was t...
On the UE Context Retrieval Enhancements for Improved Inter-RAT Mobility (2020)

Standardization efforts for 5G New Radio (NR) technology are completed and initial deployments based on both Non Standalone (NSA) mode and Standalone (SA) mode have gained momentum in several countries. The 5G rollouts i.e. NSA and SA mode lead to an interim situation where mobile operators need to maintain both Evolved Packet Core (EPC) and 5G Core (5GC). Mobile operators, in future may prefer to migrate to 5GC, albeit maintaining the LTE and NR Radio Access Technology (RAT) to preserve investments. UE inter-RAT (IRAT) mobility between LTE and NR RAT mobility within 5GC, or between EPC and 5GC will be a crucial Key Performance Indicator (KPI) for mobile operators. IRAT mobility for CONNECTED state is already supported in 3GPP specifications but very less attention is paid to mobility when the UE is in INACTIVE state or when the UE performs recovery from Radio Link Failure (RLF). INACTIVE state is supported in both LTE and NR RAT when connected to 5GC, whereas suspend mode in IDLE state is supported when LTE RAT connects to EPC. In this paper we propose UE context retrieval procedure enhancements to support: a) efficient UE mobility between LTE and NR when the UE is in INACTIVE state or suspend mode in IDLE state in LTE and b) enhancements for RLF recovery by allowing reestablishment procedure to be performed if cell selection results in suitable IRAT cell detection. Further, we studied the control plane latency performance and signaling overhead reduction during the IRAT mobility scenarios by applying proposed enhancements. We believe that the UE context retrieval enhancements during IRAT mobility in above mentioned scenarios will improve robustness and minimize service interruption thereby improving the mobility experience.
NCOG-12. IMPACT OF TUMOR-RELATED SEIZURES ON MENTAL HEALTH DISORDER ORDER IN LOW-GRADE GLIOMA (2022)

Abstract INTRODUCTION Majority of LGG patients experience seizures during their disease course, requiring anti-epileptic drugs (AEDs). Frequent seizures negatively impact health-related quality of life (HRQoL). AEDs, moreover, are hypothesized to have mood-modulating effects. As survival for LGG patients has been improving, it is essential that the impact of seizure burden and AEDs on mental health disorders (MHD) be considered. The objective was to measure an association of tumor-related seizures with MHD onset among LGG patients. METHODS This retrospective cohort study queried data from the IBM Watson Health MarketScan® Claims and Encounters Database (2005-2014) to identify LGG patients without prior MHD history who experienced glioma-related seizures. Presence of seizures was determined by anti-epileptic drug fills within one year following LGG diagnosis. Patients with new onset of MHDs were identified using ICD-9 codes for MHDs and psychotropic drug fills in the 12 months post-LGG diagnosis period. Unadjusted odds ratios measured associations between seizures and MHD prevalence. RESULTS 11,458 LGG patients with no history of MHD were included; 1,799 (15.7%) experienced seizures within 12 months of LGG diagnosis. Among them, 494 (27.5%) developed MHD in the post-LGG diagnosis period. Patients who experienced seizures were more likely to develop an MHD compared to patients who did not (OR, 2.19, 95% CI, 1.95–2.47). MHD incidence was significantly associated with female gender (OR, 1.14, 95%, 1.03–1.26) and age range of 35–44 (OR, 1.20, 95%, 1.03–1.39) compared to 18–34. CONCLUSION These findings demonstrated that tumor-related seizures were associated with MHD onset. This highlights the burden of seizures and regular AED use on mental health. The psychosocial and neurological aspects related to seizures and AEDs likely contribute to the multifaceted mental health disorder onset seen among these LGG patients. Proactive counseling, diagnosis, and management of MHDs in LGGs, particularly those with seizures, is warranted.
Towards safer blood transfusion practice (1999)

The objective of this study was to determine the current state of transfusion practice at a large metropolitan hospital in South Australia, with a view to making recommendations to improve safety. Transfusion practice was monitored using a questionnaire and a concurrent audit design. Patients identified as having received a packed red blood cell transfusion in the previous 24 h, were selected by a random number generator. Questions included those about blood pack identification, documentation of the transfusion process, and patient observation. The results of this audit indicated that areas of documentation, primarily patient consent, blood pack administration times and patient monitoring required re-evaluation. Recommendations to improve practice were made based on these results. This is an ongoing service provided by the hospital, which has proven invaluable in identifying deficiencies in transfusion practice in order to improve patient care.