gebhart/patrepeval huggingface dataset:
A Novel Cross-Species Antagonist to A3 Adenosine Receptors Lowers Mouse Intraocular Pressure Measured Non-Invasively (2008)

The Association for Research in Vision and Ophthalmology (ARVO) 2008 Annual Meeting, Fort Lauderdale, Florida, USA, 27 April-1 May 2008
Current and Future Clinical Strategies in Colon Cancer Prevention and the Emerging Role of Chemoprevention (2007)

In the third millennium preventive medicine is becoming a corner stone in our concept of health. Colorectal cancer (CRC) fits the criteria of a disease suitable for prevention interventions. It is a prevalent disease that is associated with considerable mortality and morbidity rates, with more than 1,000,000 new cases and 500,000 deaths annually. CRC has a natural history of transition from precursor to malignant lesion that spans, on average, 10-15 years, providing a window of opportunity for effective interventions and prevention. Indeed, CRC is preventable in up to 90% of the cases. Simple life style modifications (balanced diet avoidance of smoking and alcohol, and moderate physical activity) can prevent up to 50% of the cases of colorectal cancer. Compliance with current screening methods is a major barrier to the achievement of optimal results, a large part of the average risk population has not been screened by any method. Several newly developed screening modalities, such as the virtual colonoscopy and stool genetic testing may improve compliance. In addition, chemoprevention, a new science that has emerged during the last decade, presents an alternative approach to reducing mortality from colorectal cancer as well as other cancers. Chemoprevention involves the long-term use of a variety of oral agents that can delay, prevent or even reverse the development of adenomas in the large bowel. In light of the recent evidence of the efficacy of chemoprevention in persons at high risk for CRC cancer, it seems only appropriate to consider similar strategies for the general population.
BER-based Adaptation of I/O Link Equalizers (2007)

Many equalization techniques have been demonstrated for multi-Gb/s I/O transceivers in order to compensate for the limited bandwidth of the communication medium. Since the performance of links is typically defined by the bit-error-rate (BER), this paper proposes a new adaptation method using the BER as the objective function to maximize the receiver voltage margin. Measurement results compare the new algorithm with commonly used sign-sign least mean square (SS-LMS) adaptation. The results show significant improvement when applied to a transmitter FIR equalizer with peak power constraint, and modest improvement when used in a receiver DFE.
Transmission electron microscopy of solution‐processed, intrinsic and Al‐doped ZnO nanowires for transparent electrode fabrication (2010)

A solution-based chemistry was used to synthesize intrinsic and Al-doped (1% and 5% nominal atomic concentration of Al) ZnO nanostructures. The nanowires were grown at 300 degrees C in trioctylamine by dissolving Zn acetate and Al acetate. Different doping conditions gave rise to different nanoscale morphologies. The effect of a surfactant (oleic acid) was also investigated. An electron microscopy study correlating morphology, aspect ratio and doping of the individual ZnO wires to the electrical properties of the spin coated films is presented. HRTEM revealed single crystalline [0001] wires.
Identification of actionable targets in chromophobe renal cell carcinoma detected by multiplatform molecular analysis. (2015)

451 Background: Chromophobe renal cell carcinoma (chRCC) is a rare kidney cancer subtype that infrequently metastasizes or recurs after definitive local therapy. Limited biomarker data exists to prognosticate outcome or predict response to therapy. We explored the utility of multiplatform tumor profiling, which uses immunohistochemistry (IHC) and targeted next generation sequencing (tNGS) to identify druggable targets, with the intent of developing targeted therapy protocols in patients with (chRCC). Because of the non-aggressive nature of small chRCCs, we excluded T1a tumors. Methods: Cases were identified from 65,000+ tumors submitted for commercial testing at Caris Life Sciences. All tissues were internally reviewed by a dedicated genitourinary pathologist to confirm diagnosis. Markers were analyzed on tumor tissue removed during partial or radical nephrectomy. IHC was performed on 19 proteins. FISH was performed on EGFR, HER2, and TOP2A. tNGS was performed on 47 genes. Results: Twelve patients with chRCC were profiled. Five patients had metastatic disease. Median age was 54 years old; 50% of patients were male. One patient had a T1b tumor, two patients had T2 tumors, 8 patients had T3 tumors, and one had a T4 tumor. Thymidylate synthase (TS), ribonucleotide reductase M1 (RRM1), and O-6-methylguanine-DNA methyltransferase (MGMT) expression was absent in 12/12, 11/12 and 11/12 tumors, respectively. PTEN expression was absent in 7/12 of tumors. cKIT and PDGFR was expressed in 6/9 and 0/4 tumors, respectively. Lastly, point mutations in APC and TP53 were detected in 1/7 and 3/7 tumors, respectively. No mutations were identified in the other 45 genes tested and no changes in copy number were identified. Conclusions: Biomarker analysis showed that advanced chRCC might be amenable to chemotherapy with 5-fluorouracil, gemcitabine, or temozolamide because of absent TS, RRM1, and MGMT expression, respectively. Such rationale has been used successfully in targeted treatment of other cancers. In addition, sunitinib or imatinib but not sorafenib might be preferred tyrosine kinase inhibitors, as cKIT but not PDGFR was detected.
Synthese von Enopeptin B aus Streptomyces sp. RK‐1051 (1997)

Ein Cyclopeptolid, ein Polyen und ein Aminoredukton , Spezies vollkommen unterschiedlicher Biogenese, sind die Komponenten des — insbesondere gegen Staphylococcus aureus — antibiotisch wirksamen Naturstoffs Enopeptin B 1 . Die erste Totalsynthese dieser Verbindung einer neuartigen Substanzklasse gelang nun durch geschickte Anwendung des Methodenarsenals der modernen Peptidchemie, wobei die drei Bausteine auf zwei Wegen miteinander kombiniert wurden. magnified image
Authors' reply (1998)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Vasoactive mediators and pulmonary hypertension after cigarette smoke exposure in the guinea pig (2005)

The pathogenesis of pulmonary hypertension in patients with chronic obstructive pulmonary disease is not understood. We have previously shown increased levels of mediators that control vasoconstriction (endothelin-1), vascular cell proliferation (endothelin-1 and vascular endothelial growth factor), and vasodilation (endothelial nitric oxide synthase) in the intrapulmonary arteries of animals exposed to cigarette smoke. To determine whether these mediators could be implicated in the structural remodeling of the arterial vasculature and increased pulmonary arterial pressure caused by chronic cigarette smoke exposure, guinea pigs were exposed to daily cigarette smoke for 6 mo. Pulmonary arterial pressures were measured. Intrapulmonary artery structure was analyzed by morphometry, artery mediator protein expression by immunohistochemistry, and artery mediator gene expression by laser capture microdissection and real-time RT-PCR. We found that the smoke-exposed animals developed increases in pulmonary arterial pressure and increased muscularization of the small pulmonary arteries. Gene expression and protein levels of all three mediators were increased, and pulmonary arterial pressure correlated both with the levels of mediator production and with the degree of arterial muscularization. We conclude that chronic smoke exposure produces increased vasoactive mediator expression in the small intrapulmonary arteries and that these mediators are associated with vascular remodeling as well as increased pulmonary arterial pressure. These findings support the idea that hypertension in chronic obstructive pulmonary disease is a result of direct cigarette smoke-mediated effects on the vasculature and suggest that interference with endothelin and VEGF production and activity or augmentation of nitric oxide levels may be beneficial.
Statistical evaluation for trap energy level of RTS characteristics (2010)

The energy distributions of traps which cause RTS noise using the array test pattern having a large number of n-MOS and p-MOS are investigated. The more traps which cause RTS noise located near the conduction band. The phenomena in p-MOS are almost the same as n-MOS. However, the number of traps in p-MOS is less than that in n-MOS. The tendency of the energy distribution of the traps near the conduction band edge is different from that near the valence band edge.
Automated measurements of human cone photoreceptor density in healthy and degenerative retina by region-based segmentation (2017)

These results suggest that our method is more stable than conventional methods in cases of non-periodical photoreceptor structures such as the affected retinal area. Our method can be used in the longitudinal follow-up of retinal degenerative diseases and to determine the effect of therapy.
An M/G/1 Queue With a Hybrid Discipline (1983)

In this paper we analyze the delay in a single-server queue in which the server, when it becomes free, selects for the next service the oldest customer with current delay smaller than T. If no such customer is present, then it selects the youngest customer with the current delay in excess of T. This service discipline is desirable in applications where the success or failure of a service depends on the delay in providing the service. Telephone call processing and steel rolling are two of these applications. We obtain the delay distribution for this service discipline using a combination of level-crossing arguments and renewal theory, and compare this performance with that of the last-in-first-out discipline with respect to the throughput of successfully served customers.
Controlled fragrance release from galactose-based pro-fragrances (2014)

Conjugating α,β-unsaturated ketones<italic>via</italic>a thioether linkage to carbohydrates is an efficient way to modulate the polarity of the precursors and thus to influence the release of damascones in functional perfumery.
Multiplicity dependence of jet-like two-particle correlation structures in p–Pb collisions at sNN=5.02 TeV (2014)

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destine au dpt et la diffusion de documents scientifiques de niveau recherche, publis ou non, manant des tablissements d'enseignement et de recherche franais ou trangers, des laboratoires publics ou privs.
Evaluating sampling methods for uncooperative collections (2007)

Many server selection methods suitable for distributed information retrieval applications rely, in the absence of cooperation, on the availability of unbiased samples of documents from the constituent collections. We describe a number of sampling methods which depend only on the normal query-response mechanism of the applicable search facilities. We evaluate these methods on a number of collections typical of a personal metasearch application. Results demonstrate that biases exist for all methods, particularly toward longer documents, and that in some cases these biases can be reduced but not eliminated by choice of parameters.We also introduce a new sampling technique, "multiple queries", which produces samples of similar quality to the best current techniques but with significantly reduced cost.
Shared within-host SARS-CoV-2 variation in households (2022)

Abstract Background The limited variation observed among SARS-CoV-2 consensus sequences makes it difficult to reconstruct transmission linkages in outbreak settings. Previous studies have recovered variation within individual SARS-CoV-2 infections but have not yet measured the informativeness of within-host variation for transmission inference. Methods We performed tiled amplicon sequencing on 307 SARS-CoV-2 samples from four prospective studies and combined sequence data with household membership data, a proxy for transmission linkage. Results Consensus sequences from households had limited diversity (mean pairwise distance, 3.06 SNPs; range, 0-40). Most (83.1%, 255/307) samples harbored at least one intrahost single nucleotide variant (iSNV; median: 117; IQR: 17-208), when applying a liberal minor allele frequency of 0.5% and prior to filtering. A mean of 15.4% of within-host iSNVs were recovered one day later. Pairs in the same household shared significantly more iSNVs (mean: 1.20 iSNVs; 95% CI: 1.02-1.39) than did pairs in different households infected with the same viral clade (mean: 0.31 iSNVs; 95% CI: 0.28-0.34), a signal that increases with increasingly liberal thresholds. Conclusions Although only a subset of within-host variation is consistently shared across likely transmission pairs, shared iSNVs may augment the information in consensus sequences for predicting transmission linkages.
Equation-of-State Analysis of Binary Copolymer Systems. 1. Screening Effect (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEquation-of-State Analysis of Binary Copolymer Systems. 1. Screening EffectToshiaki Hino, Yuhua Song, and John M. PrausnitzCite this: Macromolecules 1995, 28, 17, 5709–5716Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/ma00121a004https://doi.org/10.1021/ma00121a004research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High-power 4-/spl mu/m Quantum Cascade lasers (2005)

We describe the design and implementation of a broad-gain and low-threshold (Jth = 860 A/cm 2 at 8 K) quantum-cascade laser based on strain-compensated In0.73Ga0.27As-AlAs on InP. Laser emission between 3.7 and 4.2 µm is achieved up to room temperature because the very large Γ-valley conduction band discontinuity with narrow quantum wells, allowing large intersubband energy differences. Furthermore, the design inhibits carrier loss from the upper lasing state into the continuum even at elevated operating temperatures. Laser operation in pulsed mode is achieved up to a temperature of 330 K with maximum single-facet output peak powers of 6 W at 8 K and 240 mW at 296 K. The temperature coefficient T0 is 119 K. The 30-period structure exhibits an external differential efficiency of 13 (40%/period) at low temperatures and a maximum wall-plug efficiency of 24%. The lasing transition takes place from several upper states to several lower states, resulting in a relatively broad (300 cm -1 ) gain spectrum and could allow the design to be used in external tuning configurations.
AMemImp: Novel Analog Memimpedance Device and Circuits for MAC Unit (2022)

This work presents a novel planar memimpedance device, named AMemImp, that consists of a Silver/reduced Graphene Oxide/Silver junction. AMemImp exhibits a unique ability for analog memimpedance tuning. For the first time in the literature, it is shown that the resistance and the capacitance of AMemImp device can be tuned simultaneously using a suitable voltage pulse. The oxide gap size (the distance between the metal electrodes) effect on both resistance and capacitance is also studied. It is proved that AMemImp capacitance follows semiconductors-based capacitance behavior during full ON state, while it has the insulator-based parallel plate capacitance characteristics during full OFF state. As a demonstrator, the analog capacitance switching behavior of AMemImp is utilized to build 2 capacitors and 2 transistors (2C2T) computation cell to perform multiply-and-accumulate operation. The non-volatile memcapacitor is exploited to store the data during the programming mode and perform multiplication in the computation mode. The 2C2T is used in a 5x4 crossbar where 20 operations are achieved in a single clock cycle with an error of 5.7%. AMemImp is considered great merit for tunable memory, computing, and RF systems.
Integrated optic dispersion slope equaliserfor N × 20 Gbit/s WDM transmission (2001)

The fabrication of a dispersion slope equaliser on a silica-based planar lightwave circuit for 16 × 20 Gbit/s wavelength division multiplexing transmission is reported. This device comprises an array of sixteen equalisers with different compensation values and an arrayed-waveguide grating for wavelength multiplexing.
Toll-like receptor 4 is not required for the full maturation of dendritic cells or for the degradation of Gram-negative bacteria (2002)

Toll-like receptor 4 (TLR4) has been recently associated with cellular responses to lipopolysaccharide (LPS), and mice mutated in tlr4, such as C57BL/10ScCr or C3H/HeJ mice, become hyporesponsive to LPS. In this study, we have analyzed the capacity of bone marrow-derived dendritic cells (BMDC) from C57BL/10ScCr (ScCr-BMDC) or C3H/HeJ (HeJ-BMDC) mice to respond to LPS or to Gram-negative bacteria. We show that ScCr- or HeJ-BMDC are insensitive to LPS, but can mature in response to live and killed Gram-negative bacteria. Interestingly, only ScCr-BMDC but not HeJ-BMDC, stimulated with bacteria, have reduced capacity to produce pro- and anti-inflammatory cytokines as compared to BMDC from control mice, probably due to genetic defects unrelated to the tlr4 mutation. Nevertheless, ScCr-BMDC and ScCr BM-macrophages (BM-Mphi) phagocytose Salmonella typhimurium similarly to control cells, indicating that TLR4 is not compulsory for bacterial uptake. Moreover, BM-Mphi, but not BM-DC from B10ScCr or C3H/HeJ mice, are impaired in their capacity to kill intracellular bacteria and to produce NO as compared to wild type controls. However, the bacteria killing property of BM-Mphi is completely restored by pretreating the cells with IFN-gamma. Hence, TLR4 plays different roles in DC versus Mphi.
Defects in low-k organosilicate glass and their response to processing as measured with electron-spin resonance (2011)

Defect concentrations in low-k organosilicate glass films deposited on high-resistivity silicon were measured with electron-spin resonance. Bulk dangling bonds were detected. Both plasma exposure and ultraviolet exposure were used. During argon electron cyclotron resonance plasma exposure, ion and photon bombardment increased the measured defect concentrations. Ultraviolet lamp exposure was also shown to increase the defect concentrations. Dielectric samples with various dielectric constants were examined showing that as the value of the dielectric constant was lowered, the defect concentrations were shown to increase significantly.
Effect of Two-Level Total Disc Replacement on Cervical Spine Kinematics (2009)

Cervical TDR at 2 levels can provide near-normal mobility at both levels without destabilizing the implanted segments or affecting adjacent segment motions. These observations lend support to the notion that single or multilevel cervical TDR may be advantageous when compared to fusion.
Transmission line parameters identification based on moving-window TLS and PMU data (2011)

The accuracy of transmission line parameters is crucial to power system normal operation. The development of PMU and WAMS supply a new way to obtain the real-time value of line parameters. In this paper, it is proposed that the moving-window total least squares algorithm for transmission line parameters identification directly based on PMU data. The method treats parameters constant during a time window and establish TLS model. Meanwhile, Kernel density estimation and point estimation are used to discuss the credibility of too many identification results. Comparison simulation with single sample computation demonstrates the presented algorithm can alsomaintain accuracy and stability under noisy condition. In addition, practical PMU data identification of one 500 kV transmission line verifies moving-window TLS effective.
OS06W0419 Mechanical Strength of Metallic Thin-Film Interfaces (2003)

Adhesion strength of dissimilar materials at their interfaces determines mechanical reliability of micro- and nano-scale devices. Various methods have been proposed and utilized to measure adhesion strength. However, they are mostly based on macroscopic application of delamination stresses at interfaces. On the other hand, a nano-scratch technique has a potential to measure adhesion strength in a much smaller scale. This paper presents some examples of the experimental results obtained by nano-scratch test. An excellent correlation was found between the measured adhesion strength and themicrostructure observed by transmission electron microscopy. Finite element calculation of stress distribution during nano-scratch test indicated that a large tensile stress is concentrated at the interface ahead of the indenter tip. The stress concentration was limited in a small region of approximately 50nm on the interface plane. The results suggest that the nano-scratch test is capable of measuring adhesion strength in a 50-nm scale.