gebhart/patrepeval huggingface dataset:
Characterization of optical performance and defect structures in nonlinear crystals for large aperture lasers (2003)

Summary form only given. Crystals of KDP and DKDP with dimensions of 41/spl times/41/spl times/1 cm/sup 3/ will be used as Pockels cell and harmonic conversion elements in the world's largest laser system, the National Ignition Facility (NIF). Determining the optical performance of these crystals under NIF-like conditions and understanding the connection between optical performance and internal defect structure has been a crucial part of the effort to build this facility. The crystals must exhibit a high degree of optical homogeneity, low anomalous birefringence, low absorption, uniform phase matching and high laser damage threshold at the 1st, 2nd and 3rd harmonics of Nd:YAG in order to meet the NIF goals for conversion efficiency, energy on target and beam focusability. Here we review the results of extensive spectroscopy, interferometry, polarimetry, X-ray topography, phase matching homogeneity and laser-induced damage measurements on full-scale and/or sub-scale crystals.
ChemInform Abstract: The BC Rings of Taxol by (4 + 4) Photocycloaddition. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Transient Spectroscopy of 5,7‐diiodo‐3‐butoxy‐6‐fluorone (DIBF) (2013)

Abstract DIBF (5,7‐diiodo‐3‐butoxy‐6‐fluorone) is a visible light photosensitizer for diaryliodonium salts, the latter being used in cationic photopolymerizations. Although photopolymerization of cycloaliphatic epoxide resins can be initiated by direct excitation of UV ‐absorbing diaryliodonium salts, such as (p‐octyloxy)phenyliodonium hexafluoroantimonate ( OPPI ), the short wavelengths required cause some practical problems. Sensitizers, of which DIBF is among the best, obviate the deep UV problem by allowing visible‐wavelength activation of the photoinitiator. Addition of 9,10‐diethoxyanthracene ( AN 910 E) dramatically accelerates photopolymerization under visible irradiation of the DIBF / OPPI system. We report herein the transient spectroscopy of the photosensitizer DIBF and discuss likely mechanisms for sensitization of OPPI .
Einführung (1993)

Im Sinne des Taylorismus besteht ein verteiltes Anwendungssystem aus einer Vielzahl von Teilanwendungen, die beim gemeinsamen Betrieb als Verarbeitungseinheiten den Zweck der Anwendung erfüllen. Ein verteiltes Anwendungssystem ist nicht durch eine einzige Verarbeitungseinheit konstituiert, sondern durch mehrere Verarbeitungseinheiten, die zueinander in Beziehung stehen. Die aus den Beziehungen resultierenden Koordinationsaufgaben zwischen den Verarbeitungseinheiten werden nachfolgend als Problemstellung und Zielsetzung der vorliegenden Arbeit herausgestellt. Anschließend wird detailliert der Aufbau der Arbeit erläutert, um den eingeschlagenen Lösungsweg zu skizzieren.
Pirtobrutinib after a Covalent BTK Inhibitor in Chronic Lymphocytic Leukemia (2023)

In this trial, pirtobrutinib showed efficacy in patients with heavily pretreated CLL or SLL who had received a covalent BTK inhibitor. The most common adverse events were infections, bleeding, and neutropenia. (Funded by Loxo Oncology; BRUIN ClinicalTrials.gov number, NCT03740529.).
Mid-Infrared Light Sources Using Parametric Amplification in Silicon Nanophotonic Wires (2012)

Progress toward realizing silicon-based mid-IR light sources will be reviewed. Using silicon nanophotonic wire parametric amplifiers as compact high-gain elements, synchronously-pumped wavelength-tunable mid-IR optical parametric oscillators and broadband supercontinuum sources have been demonstrated.
Observation of 180-deg domain structure of MgO:LiNbO 3 by SHG interference microscope (2001)

The SHG interference microscope was applied to the observation of the ferroelectric 180 degree(s) domain structure along the axial direction in a y-cut MgO:LiNbO<SUB>3</SUB>. Using four different SHG interference images with phase difference of 0, (pi) , +(pi) /2, and -(pi) /2, the special functions of the SHG intensities were calculated in the so- called (eta) -plane, from which the 3D domain structure was successfully obtained.
Direct imaging of current sharing in (BiPb)2Sr2Ca2Cu3Ox composite conductors (1997)

Using a high-resolution magneto-optical imaging technique, we study the flow of transport currents around cracks in monofilament (BiPb)2Sr2Ca2Cu2Ox composite conductors. Shunting through the Ag clad is directly observed. The current in the silver decays exponentially with distance from the crack as expected in a one dimensional distributed resistance model. At 77 K, the transfer length, λ, is approximately 0.56 mm, implying an interface resistivity of 7.5×10−8 Ω cm2. This transfer length is found to increase slightly with increasing temperature.
Senescent Colon and Breast Cancer Cells Induced by Doxorubicin Exhibit Enhanced Sensitivity to Curcumin, Caffeine, and Thymoquinone (2020)

Cellular senescence is a process of physiological growth arrest that can be induced by intrinsic or extrinsic stress signals. Some cancer therapies are associated with senescence of cancer cells with a typical cell cycle arrest. Doxorubicin (Dox) induces senescence by a p53-dependent pathway and telomere dysfunction of numerous cancers. However, cellular senescence induces suppression in proliferation activity, and these cells will remain metabolically active and play an important role in tumor relapse and development of drug resistance. In the current study, we investigated the apoptotic effect of curcumin (Cur), caffeine (Caff), and thymoquinone (TQ) on senescent colon cancer HCT116 and breast cancer MCF7 cell lines treated with Dox. Results showed typical senescence markers including decreased bromodeoxyuridine incorporation, increased accumulation of senescence-associated β-galactosidase (SA-β-gal), cell cycle arrest, and upregulation of p53, P-p53, and p21 proteins. Annexin-V analysis by flow cytometry revealed 2- to 6-fold increases in annexin-V-positive cells in Dox-treated MCF7 and HCT116 cells by Cur (15 µM), Caff (10 mM), and TQ (50 µM; <i>P</i> < .001). In comparison between proliferative and senescent of either HCT116 or MCF7 cells, Caff at 15 mM and TQ at 25 µM induced significant increases in apoptosis of Dox-treated cells compared with proliferative cells (<i>P</i> < .001). Data revealed that Cur, Caff, and TQ potentially induced apoptosis of both proliferative and senescent HCT116 and MCF7 cells. In vivo and clinical trials are of great importance to validate this result.
Reconfigurable Intelligent Surfaces vs. Relaying: Differences, Similarities, and Performance Comparison (2020)

IEEE Open Journal of the Communications Society ( Volume: 1 )
Behavior of the Reststrahlen Band in the 17–25 μm Spectral Region in the Diffuse Reflection Spectra of Sand and Silt Mixtures (2019)

Studies on the reflectance spectra of different mixtures of sand and silt were performed in the infrared spectral region of 7-25 µm to explore the behavior of a second reststrahlen band occurring between 17 and 25 µm with respect to different mixtures of sand and silt. The reflectance spectrum of all samples exhibited reststrahlen bands within both the long wavelength infrared (LWIR) and the very long wavelength infrared (VLWIR) regions of the reflectance spectrum. Results demonstrate that both LWIR and VLWIR reststrahlen bands increase in area as the fraction of sand increases to 80%. More importantly, the data demonstrate that the VLWIR reststrahlen band, like that in LWIR, exhibits a significant and reproducible decrease in reflectivity for mixed soil versus weathered soil.
Insulin-stimulated tyrosine protein kinase. Characterization and relation to the insulin receptor. (1984)

Utilizing histone phosphorylation as the basis for a quantitative assay, the insulin-stimulated protein kinase in human placenta has been characterized, The kinase copurifies through wheat germ agglutinin-Sepharose and DEAE-cellulose in constant ratio to the insulin binding function.Both activities are bound to the same extent on insulin-Sepharose, and the immobilized kinase, after extensive washing, exhibits activity versus histone, which closely approaches that of the insulin-stimulated, solubilized kinase.In addition, the bound kinase retains the ability to phosphorylate the
Position information based disturbance and speed observer having no influence on overflow of counter (2002)

The position information based disturbance observer estimates both disturbance torque and motor speed by using the informations of rotor position and motor current. It is expected to be useful and practical for the several industrial drive systems. However, this disturbance observer always has influence on overflow of encoder pulse counter. In order to overcome this problem, this paper proposes a new position information based disturbance and speed observer, which has no influence on overflow of encoder pulse counter. The simulation and experimental results show that the speed control system based on the proposed observer well regulates the motor speed and the motor torque stably and quickly on condition that the encoder pulse counter has the overflow phenomena.
FoxP3 in Treg cell biology: a molecular and structural perspective (2019)

Regulatory T cells (T<sub>regs</sub> ) are specialized in immune suppression and play a dominant role in peripheral immune tolerance. T<sub>reg</sub> cell lineage development and function maintenance is determined by the forkhead box protein 3 (FoxP3) transcriptional factor, whose activity is fine-tuned by its post-translational modifications (PTMs) and interaction partners. In this review, we summarize current studies in the crystal structures, the PTMs and interaction partners of FoxP3 protein, and discuss how these insights may provide a roadmap for new approaches to modulate T<sub>reg</sub> suppression, and new therapies to enhance immune tolerance in autoimmune diseases.
Small-Animal PET of Melanocortin 1 Receptor Expression Using a 18F-Labeled -Melanocyte-Stimulating Hormone Analog (2007)

(18)F-FB-NAPamide is a promising molecular probe for alpha-MSH receptor-positive melanoma PET and warrants further study.
Personalized information delivery (1992)

Increasing amounts of information in electronic form are becoming available. With this overload, it is not often possible to keep up to date with the current literature. Thus, automatic methods to filter out the non-relevant information have become more important and can serve a practical purpose. Information filtering methods could, for example, deliver personalized lists describing research that is relevant to any particular person's interests.
Influence of dissolved organic carbon on toxicity of copper to a unionid mussel ( Villosa iris ) and a cladoceran ( Ceriodaphnia dubia ) in acute and chronic water exposures (2011)

Acute and chronic toxicity of copper (Cu) to a unionid mussel (Villosa iris) and a cladoceran (Ceriodaphnia dubia) were determined in water exposures at four concentrations of dissolved organic carbon (DOC; nominally 0.5, 2.5, 5, and 10 mg/L as carbon [C]). Test waters with DOC concentrations of 2.5 to 10 mg C/L were prepared by mixing a concentrate of natural organic matter (Suwannee River, GA, USA) in diluted well water (hardness 100 mg/L as CaCO(3) , pH 8.3, DOC 0.5 mg C/L). Acute median effect concentrations (EC50s) for dissolved Cu increased approximately fivefold (15-72 µg Cu/L) for mussel survival in 4-d exposures and increased about 11-fold (25-267 µg Cu/L) for cladoceran survival in 2-d exposures across DOC concentrations from 0.5 to 10 mg C/L. Similarly, chronic 20% effect concentrations (EC20s) for the mussel in 28-d exposures increased about fivefold (13-61 µg Cu/L for survival; 8.8-38 µg Cu/L for biomass), and the EC20s for the cladoceran in 7-d exposures increased approximately 17-fold (13-215 µg Cu/L) for survival or approximately fourfold (12-42 µg Cu/L) for reproduction across DOC concentrations from 0.5 to 10 mg C/L. The acute and chronic values for the mussel were less than or approximately equal to the values for the cladoceran. Predictions from the biotic ligand model (BLM) used to derive the U.S. Environmental Protection Agency's ambient water quality criteria (AWQC) for Cu explained more than 90% of the variation in the acute and chronic endpoints for the two species, with the exception of the EC20 for cladoceran reproduction (only 46% of variation explained). The BLM-normalized acute EC50s and chronic EC20s for the mussel and BLM-normalized chronic EC20s for the cladoceran in waters with DOC concentrations of 2.5 to 10 mg C/L were equal to or less than the final acute value and final chronic value in the BLM-based AWQC for Cu, respectively, indicating that the Cu AWQC might not adequately protect the mussel from acute and chronic exposure, and the cladoceran from chronic exposure.
Novel Synthetic Monoketone Transmute Radiation-Triggered NFκB-Dependent TNFα Cross-Signaling Feedback Maintained NFκB and Favors Neuroblastoma Regression (2013)

Recently, we demonstrated that radiation (IR) instigates the occurrence of a NFκB-TNFα feedback cycle which sustains persistent NFκB activation in neuroblastoma (NB) cells and favors survival advantage and clonal expansion. Further, we reported that curcumin targets IR-induced survival signaling and NFκB dependent hTERT mediated clonal expansion in human NB cells. Herein, we investigated the efficacy of a novel synthetic monoketone, EF24, a curcumin analog in inhibiting persistent NFκB activation by disrupting the IR-induced NFκB-TNFα-NFκB feedback signaling in NB and subsequent mitigation of survival advantage and clonal expansion. EF24 profoundly suppressed the IR-induced NFκB-DNA binding activity/promoter activation and, maintained the NFκB repression by deterring NFκB-dependent TNFα transactivation/intercellular secretion in genetically varied human NB (SH-SY5Y, IMR-32, SK-PN-DW, MC-IXC and SK-N-MC) cell types. Further, EF24 completely suppressed IR-induced NFκB-TNFα cross-signaling dependent transactivation/translation of pro-survival IAP1, IAP2 and Survivin and subsequent cell survival. In corroboration, EF24 treatment maximally blocked IR-induced NFκB dependent hTERT transactivation/promoter activation, telomerase activation and consequent clonal expansion. EF24 displayed significant regulation of IR-induced feedback dependent NFκB and NFκB mediated survival signaling and complete regression of NB xenograft. Together, the results demonstrate for the first time that, novel synthetic monoketone EF24 potentiates radiotherapy and mitigates NB progression by selectively targeting IR-triggered NFκB-dependent TNFα-NFκB cross-signaling maintained NFκB mediated survival advantage and clonal expansion.
Accelerating preclinical development for AAV based gene therapies: bridging the gap between discovery and clinical development (2021)

<div class="authors authors-lg"><div class="author"><div class="author-img"><img src="https://bioinsightscdn.blob.core.windows.net/uploads/lrodinoklapac.jpg" data-image="1"></div><div class="author-det"> <b>Dr. Rodino-Klapac</b> is a gene therapy pioneer who has dedicated her professional life to advancing medicines designed to treat genetically based diseases. With professional experience across industry and academia, she is renowned for her contributions to molecular genetics and gene therapy that have advanced the field. She is author to a vast body of published, peer-reviewed work, the recipient of multiple awards, a National Institutes of Health (NIH) Fellow appointee, and current Board member of the Association for Regenerative Medicine, as well as a member of the American Society for Gene and Cell Therapy, the American Academy of Neurology, and the American Association for the Advancement of Science. She is the former head of the Laboratory for Gene Therapy Research at Nationwide Children’s Hospital, established the Gene Therapy Center of Excellence within Sarepta and leads the Company’s Gene Editing Innovation Center, directing a team of researchers to discover and develop novel gene replacement and gene editing therapies. She co-founded and served as chief scientific officer of Myonexus Therapeutics, a gene therapy company focused on limb-girdle muscular dystrophies acquired by Sarepta in 2019. She currently serves as Sarepta’s Executive Vice President, Chief Scientific Officer. Her work has led to 11 investigational new drug applications and she is the co-inventor of SRP-9001, an investigational micro-dystrophin gene therapy, and the inventor of five investigational gene therapies for limb-girdle muscular dystrophy. She is the inventor of over 50 U.S. and over 70 international published patent applications. She earned her Ph.D. in molecular genetics from the Ohio State University and graduated summa cum laude from Kings College in Wilkes-Barre, Pennsylvania, with a Bachelor of Science degree in Biology. <i></i><!--EndFragment--> </div></div></div>
Diagnosing small bowel carcinoid tumor in a patient with oligometastatic prostate cancer imaged with PSMA-Targeted [18F]DCFPyL PET/CT: Value of the PSMA-RADS-3D Designation (2017)

Radiotracers targeting prostate-specific membrane antigen (PSMA), including [<sup>18</sup>F]DCFPyL, have been extensively investigated as a means to image prostate cancer more accurately. We present the case of a man with oligometastatic prostate cancer who was also diagnosed with a metastatic small bowel carcinoid tumor following the detection of indeterminate findings on a [<sup>18</sup>F]DCFPyL PET and discuss how this case highlights the utility of a newly proposed reporting system for PSMA-targeted PET (PSMA-RADS version 1.0).
Characterization and metabolic regulation of a liver-specific 5.4-kilobase mRNA whose synthesis is transcriptionally induced by carbohydrates and repressed by glucagon and cyclic AMP (1985)

Four clones derived from a carbohydrate-induced rat liver cDNA library were found to hybridize with a 5.4-kilobase mRNA species encoding a 36 kDa protein. This mRNA was abundant in the liver, barely detectable in adipocytes and kidney, and absent from the other tissues tested. In the liver, the mRNA was fully induced by a carbohydrate-rich diet, but was undetectable during both starvation and feeding with a protein-rich or lipid-rich diet. Adrenalectomized, thyroidectomized and diabetic animals did not express the mRNA in their liver when re-fed with the carbohydrate-rich diet. When these animals were given the missing hormone, the amount of hybridizable RNA returned to normal values, but administration of the hormone alone failed to induce mRNA synthesis in starved animals. Both glucagon and its second messenger, cyclic AMP, abolished the induction of the mRNA in re-fed animals. Exogenous insulin, whatever the dose, did not reverse the inhibitory action of glucagon. In an isolated nuclei transcription system, no detectable RNA transcripts were found in starved animals, whereas feeding the animals with the carbohydrate-rich diet led to a maximum rate of gene transcription. Although unidentified, this mRNA proves to be a remarkable marker of dietary and hormonal control of gene expression in vivo. It will provide a useful model for further analysis of the role of cyclic AMP in regulating the transcription of eukaryotic genes.
FIPAC: Thwarting Fault- and Software-Induced Control-Flow Attacks with ARM Pointer Authentication (2021)

With the improvements of computing technology, more and more applications embed powerful ARM processors into their devices. These systems can be attacked by redirecting the control-flow of a program to bypass critical pieces of code such as privilege checks or signature verifications. Control-flow hijacks can be performed using classical software vulnerabilities, physical fault attacks, or software-induced fault attacks. To cope with this threat and to protect the control-flow, dedicated countermeasures are needed. To counteract control-flow hijacks, control-flow integrity~(CFI) aims to be a generic solution. However, software-based CFI typically either protects against software or fault attacks, but not against both. While hardware-assisted CFI can mitigate both types of attacks, they require extensive hardware modifications. As hardware changes are unrealistic for existing ARM architectures, a wide range of systems remains unprotected and vulnerable to control-flow attacks. In this work, we present FIPAC, an efficient software-based CFI scheme protecting the execution at basic block granularity of ARM-based devices against software and fault attacks. FIPAC exploits ARM pointer authentication of ARMv8.6-A to implement a cryptographically signed control-flow graph. We cryptographically link the correct sequence of executed basic blocks to enforce CFI at this granularity. We use an LLVM-based toolchain to automatically instrument programs. The evaluation on SPEC2017 with different security policies shows a code overhead between 54-97\% and a runtime overhead between 35-105%. While these overheads are higher than for countermeasures against software attacks, FIPAC outperforms related work protecting the control-flow against fault attacks. FIPAC is an efficient solution to provide protection against software- and fault-based CFI attacks on basic block level on modern ARM devices.
Effects on coagulation factor production following primaryhepatomitogen-induced direct hyperplasia (2009)

Investigating the coagulation cascade protein profiles during liver regeneration by DH may help to better understand the basic biology of the liver under normal and pathological conditions.
A Guide for Aircraft Certification by Analysis (2021)

Analysis-based means of compliance for airplane and engine certification, commonly known as Certification by Analysis (CbA), provides a strong motivation for the development and maturation of current and future flight and engine modeling technology. The many benefits of CbA include streamlined product certification testing programs at lower cost while maintaining equivalent levels of safety. Flight and engine testing represent a substantial cost to airplane and engine development programs. This report provides a far-reaching vision for CbA and presents a research roadmap for computational technology development to enable CbA.
A new imaging science test object for performance measurements of ultrasonic imaging systems (1997)

A novel test object for ultrasound imaging has been developed. The test object, or phantom, is manufactured with thin film techniques allowing precise placement of ‘‘digital scatterers’’ which can produce sophisticated test targets, similar to those that are widely used in imaging science to evaluate displays, printers, and electronic imaging systems. This type of test object can be used to determine parameters such as the MTF and resolution limits, and can facilitate the detection of imaging phenomena and artifacts such as spatial warping and spatial frequency aliasing. These test objects can be used in conjunction with standard performance evaluation methods and devices to augment and enhance their capabilities and range of application. In addition, by imparting an appropriate motion to the target, it is possible to provide unique test stimuli for pulsed and continuous wave as well as color flow and color energy Doppler ultrasound systems. Results are presented which demonstrate how the ability to make precise line targets allowed the assessment of direction related resolution and spatial frequency response by inspection, thus facilitating the implementation of a simple evaluation procedure.