gebhart/patrepeval huggingface dataset:
Maintenance of the Ratio of Bioactive to Immunoreactive Follicle-Stimulating Hormone in Normal Men During Chronic Luteinizing Hormone-Releasing Hormone Agonist Administration* (1988)

Chronic administration of LHRH agonist analogs to humans reduces gonadal function through pituitary desensitization. Serum immunoreactive gonadotropin levels are modestly reduced, whereas serum bioactive LH levels are drastically suppressed. The effects on bioactive FSH levels, however, are not known. In this study, serum bioactive FSH was measured using an in vitro granulosa cell aromatase bioassay in four normal men given a LHRH agonist, [D-Trp6,Pro9-NEt]LHRH (LHRHA; 500 micrograms/day for 16 weeks), by sc infusion and testosterone enanthate (TE; 100 mg, im every 2 weeks) and in five men given 500 micrograms/day LHRHA by daily sc injection for 20 weeks and TE (100 mg every 2 weeks) from weeks 10 through 20. During the first study, serum immunoreactive FSH levels (IR-FSH) decreased by 56.5 +/- 4.8% (+/- SEM), and serum bioactive FSH (Bio-FSH) level decreased by 57.6 +/- 6.4%. The ratio of Bio-FSH to IR-FSH did not change. During the second study, both serum IR-FSH and Bio-FSH levels followed a triphasic pattern, decreasing slightly but not significantly immediately after initiation of LHRHA administration, progressively increasing to a peak (P less than 0.5 vs, baseline) at week 10, and then, after addition of TE to this regimen, decreasing slightly again. The Bio-FSH to IR-FSH ratio, as in the first study, did not change. When serum obtained at week 10 during the second study, just before initiation of TE, was chromatographed on a Sephadex G-100 column, IR-LH eluted in two distinct peaks, while IR-FSH eluted as a single peak. These results demonstrate that in normal men chronic LHRHA administration alone for up to 10 weeks or LHRHA plus TE for up to 16 weeks does not alter the qualitative characteristics of secreted FSH, since there was no dissociation between serum IR- and Bio-FSH levels.
Ni-Electrocatalytic C(sp3)–C(sp3) Doubly Decarboxylative Coupling (2021)

This work presents a modern spin on one of the oldest known Csp3–Csp3 bond forming reactions in synthetic chemistry: the Kolbe electrolysis. This reaction holds incredible promise for synthesis, yet its use has been near non-existent in mainstream organic synthesis. In contrast to the strongly oxidative electrolytic protocol employed traditionally since the 19th century, the present method utilizes in situ generated redox-active esters (RAEs) which are combined with a mildly reductive Ni-electrocatalytic cycle. It can be used to heterocouple 1o, 2o, and even certain 3o RAEs with a protocol reminiscent of amide bond formation in terms of simplicity. Due to its mild nature the reaction tolerates a range of functional groups, is scalable, and was strategically enlisted for the synthesis of 25 known compounds to reduce overall step-counts by 74%.
Coupled vibrations of a varying length flexible cable transporter system with arbitrary axial velocity (2004)

Modeling for coupled vibrations of a varying length flexible cable transporter system with arbitrary axial velocity is presented using the extended Hamilton's principle. Both transverse and longitudinal vibrations are considered simultaneously in the derivation. The inertia and damping of the pulleys and actuators are included in the model. The derived governing equations provide guidelines for future research on cable systems. Numerical solution of the derived nonlinear coupled partial differential equations (PDEs) is obtained using Galerkin's method. Simulation results show that increase in damping of the system can reduce the longitudinal vibration dramatically, but has little effect on the transverse vibration.
Running of the top quark mass from proton-proton collisions at s=13TeV (2020)

The running of the top quark mass is experimentally investigated for the first time. The mass of the top quark in the modified minimal subtraction (MS) renormalization scheme is extracted from a comparison of the differential top quark-antiquark (t t) cross section as a function of the invariant mass of the t t system to next-to-leading-order theoretical predictions. The differential cross section is determined at the parton level by means of a maximum-likelihood fit to distributions of final-state observables. The analysis is performed using t t candidate events in the e channel in proton-proton collision data at a centre-of-mass energy of 13 TeV recorded by the CMS detector at the CERN LHC in 2016, corresponding to an integrated luminosity of 35.9 fb -1 . The extracted running is found to be compatible with the scale dependence predicted by the corresponding renormalization group equation. In this analysis, the running is probed up to a scale of the order of 1 TeV.
Semi-permeability of graphene nanodrums in sucrose solution (2020)

Abstract Semi-permeable membranes are important elements in water purification and energy generation applications, for which the atomic thickness and strength of graphene can enhance efficiency and permeation rate while maintaining good selectivity. Here, we show that an osmotic pressure difference forms across a suspended graphene membrane as a response to a sucrose concentration difference, providing evidence for its semi-permeability. This osmotic pressure difference is detected via the deflection of the graphene membrane that is measured by atomic force microscopy. Using this technique, the time dependence of this deflection allows us to measure the water permeation rate of a single 3.4 µ m diameter graphene membrane. Its value is close to the expected value of a single nanopore in graphene. The method thus allows one to experimentally study the semi-permeability of graphene membranes at the microscale when the leakage rate is minuscule. It can therefore find use in the development of graphene membranes for filtration, and can enable sensors that measure the concentration and composition of solutions.
An Atomistic Description of the γ-Alumina/Water Interface Revealed by Ab Initio Molecular Dynamics (2017)

We report ab initio molecular dynamics (AIMD) simulations of the (100) and (110) γ-Al2O3/water interfaces at 300 K, using two sets of supercell models for each surface and two time lengths of simulation (10 and 40 ps). We first show that the effect of liquid water on the vibrational frequencies of hydroxyl groups at the interface varies according to the type of surface. This trend is explained by two key parameters affecting the interaction of both surfaces with water: the nature of the OH groups (i.e., μ1-OH, μ1-H2O, μ2-OH, and μ3-OH) and H-bond network among surface OH groups. The hydroxylated (110) surface favors the local structuration of water at the interface and the solvation of its μ1-OH and μ1-H2O groups by water similarly as in bulk liquid water. By contrast, on the (100) surface, a stronger H-bond network among μ1-OH and μ1-H2O groups reduces the water/surface interaction. We illustrate also how the interfacial interacting sites are spatially organized on the surfaces by two-dimensional maps of O–H distances. On both surfaces, the interfacial water layer orientation is predominantly Hup–Hdown. For long AIMD simulation time, Grotthuss-like mechanisms are identified on the (110) surface.
A Bridge from System to Software Development for Safety-Critical Automotive Embedded Systems (2012)

In this paper, we present a tool enhancement that allows an effective transition from the system level development phase to the software level development phase of a tool-supported safety engineering workflow aligned with the automotive functional safety standard ISO 26262. The tool enhancement has capabilities for model generation and code generation. Whereas the generation of Simulink models supports the development of application software, the configuration and generation of safety drivers supports the development of the basic software required for initialization, runtime fault detection and error handling. We describe the safety engineering workflow and its supporting tool chain including the tool enhancement. Moreover we demonstrate that the enhancement supports the transition from the system level development phase to the software level development phase using the case study of a hybrid electric vehicle development.
Central America Operator Uses Versatile Surface Packoff for Improved Well-Construction Operations (2008)

Abstract While using conventional surface launch cementing plugs during cementing operations performed on large diameter surface pipe, significant costs are incurred during the pumping of cement and displacement fluids because of the large volumes involved in the job. Additionally, high differential lifting pressures sometimes exceed the safe collapse load that can be applied to the large casing; thereby preventing the operator from checking the float valves after displacement is complete. For several operational reasons, the operator elected to cement subsequently installed surface pipe using the inner-string method of displacement. To help reduce overall job execution time and provide safer means of checking the floats after displacement is complete, a versatile surface packoff was incorporated into cementing operations on many large-diameter surface jobs. The time required to run the work string and install the surface packoff was easily justified with reduced costs associated with actual job execution. This paper documents the operators cost analysis along with operational benefits realized from the use of inner-string cementing and surface packoff methods.
Panel: user modeling and user interfaces (1990)

I will consider the problem of helping user’s retrieve information from large diverse collections of textual materials such as bibliographic databases, electronic bulletin boards and online manuals, although I believe that many of my arguments apply to other interactive environments as well. Information retrieval systems like this must handle a heterogeneous population of users, and even a single user will have a range of information needs including very specific requests as well as more general and often ill-defined topical searches. The idea of employing user models to enhance human-computer interaction in IR applications is very appealing. The hope is that some form of encapsulated knowledge about the user will mediate between user input and system responses resulting in more effective, efficient and
Appia: automatic storage area network fabric design (2002)

Designing a storage area network (SAN) fabric requires devising a set of hubs, switches and links to connect hosts to their storage devices. The network must be capable of simultaneously meeting specified data flow requirements between multiple host-device pairs, and it must do so cost-effectively, since large-scale SAN fabrics can cost millions of dollars. Given that the number of data flows can easily number in the hundreds, simple overprovisioned manual designs are often not attractive: they can cost significantly more than they need to, may not meet the performance needs, may expend valuable resources in the wrong places, and are subject to the usual sources of human error. Producing SAN fabric designs automatically can address these difficulties, but it is a non-trivial problem: it extends the NP-hard minimum-cost fixed-charge multicommodity network flow problem to include degree constraints, node capacities, node costs, unsplittable flows, and other requirements. Nonetheless, we present here two efficient algorithms for automatic SAN design. We show that these produce cost-effective SAN designs in very reasonable running times, and explore how the two algorithms behave over a range of design problems.
DIFFERENTIAL FLATNESS-BASED FORMATION FOLLOWING OF A SIMULATED AUTONOMOUS SMALL GRAIN HARVESTING SYSTEM (2004)

Researchers around the world have focused on autonomous agriculture with systems encompassing greenhouse,orchard, field, and other applications. Research has shown the potential and ability of the technology to allow a vehicle orselection of vehicles to follow a specified task. In this study, one aspect of the problem, that of operating a tractor-cartcombination in conjunction with a small-grain combine harvester, was investigated. The tractor-cart combination andcombine harvester application was selected because of the high fatigue and long duration aspects of the problem. Differentialflatness-based formation following was tested in software and robotic simulation. The software simulation was based on anactual field track from a combine yield monitor and demonstrated the potential of the system. The robotic simulation usedtwo iRobot Magellan Pro robots in an indoor environment and demonstrated that the methodology could be implemented inreal time.
Search for expertise : going beyond direct evidence (2009)

to join my dissertation committee. Many thanks to David and Maarten
Benefits of inter-flow bandwidth sharing in broadband wireless infrastructure networks (2008)

Broadband wireless infrastructure networks are increasingly becoming common in metro areas. To improve spatial bandwidth usage, the nodes in such networks employ directional transmissions over multiple orthogonal channels. In this paper, we study the benefits of sharing channel bandwidth across multiple flows. Every connection is assumed to require a bandwidth that is half of the channel bandwidth. We model the routing and channel assignment problem in two different ways to account for the presence and absence of inter-flow bandwidth sharing. Through simulations, we demonstrate that supporting inter-flow bandwidth sharing through simple time-sharing mechanism results in improved network throughput.
Analysis of a Casimir-driven parametric amplifier with resilience to Casimir pull-in for MEMS single-point magnetic gradiometry (2021)

The Casimir force, a quantum mechanical effect, has been observed in several microelectromechanical system (MEMS) platforms. Due to its extreme sensitivity to the separation of two objects, the Casimir force has been proposed as an excellent avenue for quantum metrology. Practical application, however, is challenging due to attractive forces leading to stiction and device failure, called Casimir pull-in. In this work, we design and simulate a Casimir-driven metrology platform, where a time-delay-based parametric amplification technique is developed to achieve a steady-state and avoid pull-in. We apply the design to the detection of weak, low-frequency, gradient magnetic fields similar to those emanating from ionic currents in the heart and brain. Simulation parameters are selected from recent experimental platforms developed for Casimir metrology and magnetic gradiometry, both on MEMS platforms. While a MEMS offers many advantages to such an application, the detected signal must typically be at the resonant frequency of the device, with diminished sensitivity in the low frequency regime of biomagnetic fields. Using a Casimir-driven parametric amplifier, we report a 10,000-fold improvement in the best-case resolution of MEMS single-point gradiometers, with a maximum sensitivity of 6 Hz/(pT/cm) at 1 Hz. Further development of the proposed design has the potential to revolutionize metrology and may specifically enable the unshielded monitoring of biomagnetic fields in ambient conditions.
Interaction of Antidepressants with the Serotonin and Norepinephrine Transporters (2012)

The serotonin transporter (SERT) and the norepinephrine transporter (NET) are sodium-dependent neurotransmitter transporters responsible for reuptake of released serotonin and norepinephrine, respectively, into nerve terminals in the brain. A wide range of inhibitors of SERT and NET are used as treatment of depression and anxiety disorders or as psychostimulant drugs of abuse. Despite their clinical importance, the molecular mechanisms by which various types of antidepressant drugs bind and inhibit SERT and NET are still elusive for the majority of the inhibitors, including the molecular basis for SERT/NET selectivity. Mutational analyses have suggested that a central substrate binding site (denoted the S1 pocket) also harbors an inhibitor binding site. In this study, we determine the effect of mutating six key S1 residues in human SERT (hSERT) and NET (hNET) on the potency of 15 prototypical SERT/NET inhibitors belonging to different drug classes. Analysis of the resulting drug sensitivity profiles provides novel information on drug binding modes in hSERT and hNET and identifies specific S1 residues as important molecular determinants for inhibitor potency and hSERT/hNET selectivity.
HR-MAS NMR Tissue Metabolomic Signatures Cross-validated by Mass Spectrometry Distinguish Bladder Cancer from Benign Disease (2013)

Effective diagnosis and surveillance of bladder cancer (BCa) is currently challenged by detection methods that are of poor sensitivity, particularly for low-grade tumors, resulting in unnecessary invasive procedures and economic burden. We performed HR-MAS NMR-based global metabolomic profiling and applied unsupervised principal component analysis (PCA) and hierarchical clustering performed on NMR data set of bladder-derived tissues and identified metabolic signatures that differentiate BCa from benign disease. A partial least-squares discriminant analysis (PLS-DA) model (leave-one-out cross-validation) was used as a diagnostic model to distinguish benign and BCa tissues. Receiver operating characteristic curve generated either from PC1 loadings of PCA or from predicted Y-values resulted in an area under curve of 0.97. Relative quantification of more than 15 tissue metabolites derived from HR-MAS NMR showed significant differences (P < 0.001) between benign and BCa samples. Noticeably, striking metabolic signatures were observed even for early stage BCa tissues (Ta-T1), demonstrating the sensitivity in detecting BCa. With the goal of cross-validating metabolic signatures derived from HR-MAS NMR, we utilized the same tissue samples to analyze 8 metabolites through gas chromatography-mass spectrometry (GC-MS)-targeted analysis, which undoubtedly complements HR-MAS NMR-derived metabolomic information. Cross-validation through GC-MS clearly demonstrates the utility of a straightforward, nondestructive, and rapid HR-MAS NMR technique for clinical diagnosis of BCa with even greater sensitivity. In addition to its utility as a diagnostic tool, these studies will lead to a better understanding of aberrant metabolic pathways in cancer as well as the design and implementation of personalized cancer therapy through metabolic modulation.
Application of Heuristic Algorithms for Multiuser Detection (2006)

In this paper we propose application of heuristic algorithms in multiuser detection (MUD). The proposed algorithm combines a tabu search heuristic algorithm with a local search heuristic algorithm. The new proposed structure brings several improvements when compared to both the conventional (matched filter) detector and the decorrelating detector. Additionally, the algorithm proposed here fairly approximates the performance of the optimal MUD detector with much reduced computational complexity.
Effect of fumonisins and Salmonella on digestive flora profiles assessed using a molecular tool (CE-SSCP). (2007)

Fumon1s1ns (FB) are mycotox1ns frequently found 1n vegetal feedstuffs , especially m maize used for p1g feeding . Among fumonisins , FB1 was the better described toxin. It caused pulmonary and hepatic damages as well as immune response disorders in pigs that were recognised as especially sensitive to FB Intoxication. The FB1 immunosuppressor induced a higher susceptibility of p1gs to gut pathogens such as E coli. Effects on Salmonella have poorly been studied despite the frequent asymptomatic carnage m pigs and the presumptive role of nora equilibrium on prevention of Salmonella excret1on or re-excretion . To determme the innuence of Salmonella carriage, fumon1sins or both on digest1ve nora equilibrium , the use of a molecular technique CE-SSCP (Capillary-ElectrophoresiS Single Strand Conformation Polymorphism) appeared a good complement to the conventional bacteriological techniques. The obJeCtive was to assess the perturbation of nora assoc1ated with co-exposition 1n expenmental conditions m absence of clinical sign Forty eight piglets were clustered following a 2x2 "factorial scheme in order to analyse on faecal nora, the effect of a feeding naturally contammated with FB (8.5 ppm of FB , and 2.8 ppm of FB2) associated w1th an asymtomatic carriage of Salmonella Typhimunum. The effect of FB and Salmonella has been investigated onto 10 week old piglets and during 9 weeks. Faeces of the p1gs were taken regularly Bacteriological numeration of total aerobic nora was conducted . DNA of each sample was extracted us1ng the QIAmp DNA Stool Minik1t. The extracted DNA were pooled, the PCR amplification of the rONA 16S V3 reg1on was earned out. Then the PCR products were analysed by CE-SSCP. Profiles were classified v1a dendrograms usmg the BioNumerics software and the Jaccard coefficient for similarity determination In th1s study, 5 10 4 CFU Salmonella per pig induced infections and asymptomatic carriages that didn't affect the faecal nora profiles Intoxication of the p1gs by the contam1nated feed has been confirmed by the increase of the sphmganme/sphingos1ne ratio The 8.5 ppm concentration of FB, did not mduce any effect on the ammal health mdicators , but 1t affected transiently the d1gesllve nora equilibnum. In case of co-mfect1on with FB and Salmonella , the nora profiles were rapidly and strongly modified as soon as 48h post Salmonella infection. Therefore under our experimental conditions, exposure to a medium concentration of FB 1n naturally contaminated food had no effect on the p1g health but can affected the digest1ve nora equillbnum , the Salmonella exposure amplifying th1s phenomenon
Integrated vehicle control using steering and brakes (2006)

The integration of brakes and steering actuators in vehicle lateral dynamics control is of primary relevance due to the high control authority these actuators insure. Moreover this is a challenging control problem as it is MIMO, intrinsically non-linear due to tyres characteristic and with high plant uncertainty due to variations of major parameters. This paper presents the application of state feedback linearization technique to the problem and shows some vehicle test results. The controller results globally stable, smooth and effective with the steering actuator and uses the braking correction only in critical cases.
Development of Oral Formulation Technology for Nucleic Acid Drug by Using PLGA Nanoparticles as DDS Carriers (2013)

PLGA nanoparticles (NPs) have possibility to become the useful oral DDS for nucleic acid drug. The nanocomposite powder that PLGA NPs dispersed in matrix of excipient were prepared to make two kinds of solid dosage forms such as the enteric tablet and seamless capsule containing the NF-κB decoy nucleic acid loaded PLGA NPs for human oral administration model. These two solid dosage forms proposed here showed to be high applicable for the oral DDS.
Self‐organization of “fibro‐axonal” composite tissue around unmodified metallic micro‐electrodes can form a functioning interface with a peripheral nerve: A new direction for creating long‐term neural interfaces (2015)

We have demonstrated the feasibility of a novel peripheral nerve interface through modulation of normal biologic phenomena. It has potential applications as a chronic implantable neural interface.
The ferumoxytol in renal insufficiency study (FiRST) (2013)

Background Imaging in patients with renal insufficiency (RI) is limited by contrast induced nephropathy and nephrogenic systemic fibrosis. Ferumoxytol is an FDA approved superparamagnetic iron compound used for the treatment of anemia in patients with renal insufficiency. Previous studies of its use as an MRA contrast agent did not assess safety, were not conducted in patients with RI, and were limited by small sample size. We characterized the safety, image quality, and clinical impact of ferumoxytol-enhanced MRA (FeMRA) in patients with RI as compared to gadoliniumenhanced MRA (GeMRA) in patients without RI.