gebhart/patrepeval huggingface dataset:
Inhibition of experimental auto-immune uveitis by the A3 adenosine receptor agonist CF101 (2011)

Uveitis is an inflammation of the middle layer of the eye with a high risk of blindness. The Gi protein associated A3 adenosine receptor (A3AR) is highly expressed in inflammatory cells whereas low expression is found in normal cells. CF101 is a highly specific agonist at the A3AR known to induce a robust anti-inflammatory effect in different experimental animal models. The CF101 mechanism of action entails down-regulation of the NF-κB-TNF-α signaling pathway, resulting in inhibition of pro-inflammatory cytokine production and apoptosis of inflammatory cells. In this study the effect of CF101 on the development of retinal antigen interphotoreceptor retinoid-binding protein (IRBP)-induced experimental autoimmune uveitis (EAU) was assessed. Oral treatment with CF101 (10 µg/kg, twice daily), initiated upon disease onset, improved uveitis clinical score measured by fundoscopy and ameliorated the pathological manifestations of the disease. Shortly after treatment with CF101 A3AR expression levels were down-regulated in the lymph node and spleen cells pointing towards receptor activation. Downstream events included a decrease in PI3K and STAT-1 and proliferation inhibition of IRPB auto-reactive T cells ex vivo. Inhibition of interleukin-2, tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) production and up-regulation of interleukin-10 was found in cultured splenocytes derived from CF101-treated animals. Overall, the present study data point towards a marked anti-inflammatory effect of CF101 in EAU and support further exploration of this small molecule drug for the treatment of uveitis.
The Interplay between Kinetics and Thermodynamics in Furan Diels–Alder Chemistry for Sustainable Chemicals Production (2022)

Abstract Biomass‐derived furanic platform molecules have emerged as promising building blocks for renewable chemicals and functional materials. To this aim, the Diels–Alder (DA) cycloaddition stands out as a versatile strategy to convert these renewable resources in highly atom‐efficient ways. Despite nearly a century worth of examples of furan DA chemistry, clear structure–reactivity–stability relationships are still to be established. Detailed understanding of the intricate interplay between kinetics and thermodynamics in these very particular [4+2] cycloadditions is essential to push further development and truly expand the scope beyond the ubiquitous addend combinations of electron‐rich furans and electron‐deficient olefins. Herein, we provide pertinent examples of DA chemistry, taken from various fields, to highlight trends, establish correlations and answer open questions in the field with the aim to support future efforts in the sustainable chemicals and materials production.
Towards smart transmission substations with Modular Transformer Converter systems (2011)

This paper provides the background and introduces the concept of Modular Transformer Converter (MTC) system as a power flow controller for transmission substations. The MTC based power flow controller is desired also to provide back-up function due to aging and failure of transmission transformers. Several different connection configurations for the MTC based power flow controller are proposed and compared. The proposed MTC solution offers controllable and increased power flow margins as well as improved system performance under line faults and system disturbances. The proposed MTC solution is aimed at being scalable, transportable, efficient, and to increase reliability for transmission systems.
Contribution of Staphylococcus aureus Coagulases and Clumping Factor A to Abscess Formation in a Rabbit Model of Skin and Soft Tissue Infection (2016)

Staphylococcus aureus produces numerous factors that facilitate survival in the human host. S. aureus coagulase (Coa) and von Willebrand factor-binding protein (vWbp) are known to clot plasma through activation of prothrombin and conversion of fibrinogen to fibrin. In addition, S. aureus clumping factor A (ClfA) binds fibrinogen and contributes to platelet aggregation via a fibrinogen- or complement-dependent mechanism. Here, we evaluated the contribution of Coa, vWbp and ClfA to S. aureus pathogenesis in a rabbit model of skin and soft tissue infection. Compared to skin abscesses caused by the Newman wild-type strain, those caused by isogenic coa, vwb, or clfA deletion strains, or a strain deficient in coa and vwb, were significantly smaller following subcutaneous inoculation in rabbits. Unexpectedly, we found that fibrin deposition and abscess capsule formation appear to be independent of S. aureus coagulase activity in the rabbit infection model. Similarities notwithstanding, S. aureus strains deficient in coa and vwb elicited reduced levels of several proinflammatory molecules in human blood in vitro. Although a specific mechanism remains to be determined, we conclude that S. aureus Coa, vWbp and ClfA contribute to abscess formation in rabbits.
Multiplexed polymer-based chirped gratinglenses working at 632.8 nm wavelength (1995)

A multiplexed waveguide hologram containing two off-axis chirped grating lenses working at 632.8 nm was demonstrated on a glass substrate. Focal lengths of 35 and 37 mm were experimentally confirmed. The nature of phase modulation of the holographic medium allows the formation of multiplexed waveguide lenses on the same waveguide emulsion area. The graded index (GRIN) characteristic of the guiding medium allows the formation of polymer-based photonic devices on any substrate of interest which greatly enhances the transferability of polymer-based photonic integrated circuits (PICs) to various optoelectronic circuits.
Conserved transcriptional programming across sex and species after peripheral nerve injury predicts treatments for neuropathic pain (2022)

Abstract Chronic pain is a devastating problem affecting 1 in 5 individuals around the globe, with neuropathic pain the most debilitating and poorly treated type of chronic pain. Advances in transcriptomics and data mining have contributed to cataloging diverse cellular pathways and transcriptomic alterations in response to peripheral nerve injury but have focused on phenomenology and classifying transcriptomic responses. Here, with the goal of identifying new types of pain-relieving agents, we compared transcriptional reprogramming changes in the dorsal spinal cord after peripheral nerve injury cross-sex and cross-species and imputed commonalities, as well as differences in cellular pathways and gene regulation. We identified 93 transcripts in the dorsal horn that were increased by peripheral nerve injury in male and female mice and rats. Following gene ontology and transcription factor analyses, we constructed a pain interactome for the proteins encoded by the differentially expressed genes, discovering new, conserved signaling nodes. We interrogated the interactome with the Drug-Gene database to predict FDA-approved medications that may modulate key nodes within the network. The top hit from the analysis was fostamatinib, the molecular target of which is the non-receptor tyrosine kinase Syk, which our analysis had identified as a key node in the interactome. We found that intrathecally administrating the active metabolite of fostamatinib, R406, significantly reversed pain hypersensitivity in both sexes. Thus, we have identified and shown the efficacy of an agent that could not have been previously predicted to have analgesic properties. One sentence summary Unbiased approach to predicting safe therapies for neuropathic pain
Datasets for paper: Age and structure of a model vapour-deposited glass (2017)

Datasets, tools, and scripts for Age and structure of a model vapour-deposited glass. DOI: 10.1038/ncomms13062
Materials and Processes for Stretchable and Wearable e‐Textile Devices (2020)

Recent developments in materials and device design, specifically for mechanically flexible/stretchable, wearable electronics has broadened the applicability of “Internet of Things” concepts to a myriad of new fields and commercial products. This chapter summarizes the recent advances in developing flexible and stretchable conducting elements for e-textile device applications. It introduces several material classes for use as textile layer and/or support fiber. The chapter also summarizes the recent studies addressing specific devices, including interconnects, electrodes, sensors, heaters, supercapacitors, and energy generators by using metal nanomaterials, carbon nanomaterials, conducting polymers, polyaniline, and supporting fibers. The fabrication of e-textile can be achieved in two ways: via direct penetration/printing/in situ growth of the conducting materials into the fabric; by coating the conducting materials on fibers/yarns followed by fabric manufacturing. The electrical conductor is a critical element for enabling flexible and stretchable electronic devices. The chapter outlines the major challenges and opportunities that this research field is experiencing.
Interfacial and breakdown characteristics of MOS devices with rapidly grown ultrathin SiO2gate insulators (1987)

Metal-oxide-semiconductor (MOS) devices fabricated with composite gates and subhundred-angstrom SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> gate insulators grown by rapid thermal oxidation were characterized by various electrical measurements. The as-fabricated devices with unannealed rapidly grown oxides exhibited breakdown characteristics superior to furnace-grown oxides as evidenced by their excellent breakdown uniformity, an average breakdown field of 15 MV/cm, and an average breakdown charge density of over 50 C/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at a stress current density of 1 A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The preoxidation surface cleaning procedure was observed to affect the charge-to-breakdown and the densities of fixed oxide charges and surface states in these MOS structures.
FDA Oversight of Cell Therapy Clinical Trials (2012)

The U.S. Food and Drug Administration applies regulatory flexibility to balance benefits and risks to subjects in cell-therapy clinical trials.
Circulating cell-free messenger RNA secretome characterization of primary sclerosing cholangitis (2022)

ABSTRACT BACKGROUND &amp; AIMS Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic liver disease characterized by multi-focal bile duct strictures. To date, underlying molecular mechanisms of PSC remain unclear and therapeutic options for PSC patients are limited. We performed cell-free messenger RNA (cf-mRNA) next generation sequencing (RNA-Seq) to characterize the circulating transcriptome of PSC and non-invasively investigate potentially bioactive signals that are associated with PSC. METHODS Serum cf-mRNA profiles were compared among 50 individuals with PSC, 20 healthy controls, and 235 individuals with non-alcoholic fatty liver disease (NAFLD). Tissue and cell type-of-origin genes that are dysregulated in subjects with PSC were evaluated. Subsequently, diagnostic classifiers were built using PSC dysregulated cf-mRNA genes. RESULTS Differential expression analysis of the cf-mRNA transcriptomes of PSC and healthy controls resulted in identification of 1407 dysregulated genes. Furthermore, differentially expressed genes between PSC and the liver diseases (NAFL and Non-Alcohol Steatohepatitis (NASH)) or healthy controls shared common genes known to be involved in liver pathophysiology. In particular, genes from liver- and specific cell type-origin, including hepatocyte, hepatic stellate cells and Kupffer cells, were highly abundant in cf-mRNA of subjects with PSC. Gene cluster analysis revealed that liver-specific genes dysregulated in PSC form a distinct cluster which corresponded to a subset of the PSC subject population. Finally, we developed a cf-mRNA classifier using liver-specific genes which discriminated PSC from healthy control subjects using gene transcripts of liver origin. CONCLUSIONS Blood-based whole transcriptome cf-mRNA profiling revealed high abundance of liver-specific genes in PSC subject sera which may be used to diagnose PSC patients. We identified several unique cf-mRNA profiles of subjects with PSC. These findings may also have utility for non-invasive molecular stratification of subjects with PSC for pharmacotherapy safety and response studies. Graphical Abstract
An adaptive subchannel allocation algorithm for OFDM-based wireless home networks (2004)

We present a novel, adaptive subchannel allocation algorithm for the downlink channel of a multiuser, OFDM-based wireless home network. Since channel resources are not adaptively allocated in a traditional OFDM system, some of the users with fixed frequency channel allocation may experience deep fading in a frequency-selective multipath environment. This problem can be mitigated using an adaptive algorithm, which can be modeled as an optimization problem that allocates the proper number of subchannels to achieve maximum channel capacity. We employ the classical bipartite matching algorithm to achieve optimal OFDM subchannel allocation. Simulation results show that the total capacity increases remarkably, and that higher channel capacity is achieved when the number of users is increased. In a wireless environment, the reallocation overhead can be large. As such, we propose a hybrid method for subchannel allocation to support more users while reducing the reallocation overhead. We simulated the performance of the hybrid algorithm and compared it with the matching-only algorithm.
Responsabilidad Social de la Empresa Del Dicho al Hecho: Anales (2004)

Los Anales de la II Conferencia Interamericana sobre RSE celebrada en México.
Figure S1 from Autocrine Adenosine Regulates Tumor Polyfunctional CD73<sup>+</sup>CD4<sup>+</sup> Effector T Cells Devoid of Immune Checkpoints (2023)

&lt;p&gt;Th1.17 characteristics of CD73+ CD4+ Teff based on the expression of CXCR3, CCR6, CRTH2, the migration in response to CXCL10 or CCL20 gradient and the MDR-1-specific Rhodamine 123 exclusion assay&lt;/p&gt;
Preparation and assignment of configuration of cis- and trans-2,3,4,4a,5,6-hexahydro-2-naphthalenol (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and assignment of configuration of cis- and trans-2,3,4,4a,5,6-hexahydro-2-naphthalenolTed L. Underiner and Harlan L. GoeringCite this: J. Org. Chem. 1987, 52, 5, 897–900Publication Date (Print):March 1, 1987Publication History Published online1 May 2002Published inissue 1 March 1987https://pubs.acs.org/doi/10.1021/jo00381a031https://doi.org/10.1021/jo00381a031research-articleACS PublicationsRequest reuse permissionsArticle Views242Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Iminoheptitols as Glycosidase Inhibitors: Synthesis of α‐ Homomannojirimycin, 6‐epi‐α‐Homomannojirimycin and of a Highly Substituted Pipecolic Acid. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Understanding the Electrical Behavior of Pyrolyzed Three‐Dimensional‐Printed Microdevices (2020)

Herein the electrical and microstructural characterization of additively manufactured glassy carbon fabricated via two‐photon polymerization (2PP) is reported. Thermal decomposition at elevated temperatures volatizes much of the 2PP fabricated part, converting the crosslinked photopolymer into a carbon‐rich structure. Upon heating to continued elevated temperatures the carbon material becomes increasingly conductive. The ability to control the conductivity of the pyrolyzed material is done by varying the pyrolysis temperature, with maximum conductivity obtained of roughly 2 × 10 4 S m −1 . Microstructural characterization with Raman spectroscopy and transmission electron microscopy (TEM) confirms that the increase in conductivity comes from the increased sp 2 bonding percentage in carbon and increased crystallinity. This knowledge allows for the manufacturing of predictable, well‐controlled glassy carbon resistors that are within 10% of theoretical values.
Low level and high linearity amplifiers in integrated technologies for satellite receivers: Technical issues of linearization techniques (2007)

Based on carrier to third intermodulation ratio (C/I3), reverse engineering of a two stages low level amplifier has been made in order to access the current transistor nonlinear models. Comparisons between two models of HEMT have been performed in order to choose the one which represent accurately weak nonlinearities at low level power dynamic range. By judicious choice of bias point, 12 dB improvement of linearity has been achieved. Other issues of linearization techniques have been studied so that to be suitable for MMIC implementation.
Anomalous critical current in double-barrier Nb/Al–AlOx–Al–AlOx–Nb devices (1999)

Double-barrier Nb/Al–AlOx–Al–AlOx–Nb devices with a “dirty” middle Al layer were fabricated and investigated. An anomalously large Josephson critical current at low temperatures and a nonmonotonic dependence of the device resistance on the thickness of the middle Al layer were found.
Data Supplement from Neuronal Pentraxin 2 Supports Clear Cell Renal Cell Carcinoma by Activating the AMPA-Selective Glutamate Receptor-4 (2023)

&lt;p&gt;Supplementary Figure 1. (A) QPCR for NPTX2 expression in an array of normal (n=4) and ccRCC (n=7) cell lines. All samples are normalized to a water negative control. Four shRNA lentiviral constructs (sh804, sh855, sh1316, sh1623) against NPTX2 were used to infect A498 cells. (B) Description of ccRCC cell line VHL mutational status. (C) QPCR for NPTX2 mRNA in each of the A498 NT vs. target lentiviral clones. (D) Western blot analysis for NPTX2 protein expression in all four A498 NPTX2 shRNA clones compared to NT control. Protein expression level quantitation is normalized to β-actin. (E) Proliferation (7 day) rescue assay of A498 cells transfected with either a human NPTX2 expression vector (+NPTX2) plasmid or empty vector (EV) control, and infected with NT control, sh1316 or sh1623 NPTX2 targeting lentivirus.&lt;/p&gt;
Carrier frequency offset estimation for interleaved SC-FDMA systems (2012)

Carrier frequency offsets at the uplink of single carrier frequency division multiple access (SC-FDMA) systems destroy the orthogonality among the users and degrade the system performance. We present a semi-blind CFO estimation technique for SC-FDMA uplink with interleaved sub-carrier allocation. The estimation is based on the key observation that SC-FDMA with interleaved allocation obeys the parallel factor (PARAFAC) analysis model and therefore it is shown that the CFO of all the users can be uniquely estimated. Performance of the proposed method is evaluated through simulations and compared with the existing approaches in the literature.
A Non‐Doped Phosphorescent Organic Light‐Emitting Device with Above 31% External Quantum Efficiency (2014)

The demonstrated square-planar Pt(II)-complex has reduced triplet-triplet quenching and therefore a near unity quantum yield in the neat thin film. A non-doped phosphorescent organic light-emitting diode (PhOLED) based on this emitter achieves (31.1 ± 0.1)% external quantum efficiency without any out-coupling, which shows that a non-doped PhOLED can be comparable in efficiency to the best doped devices with very complicated device structures.
Security and Privacy Protection in Wireless Sensor Networks (2004)

Security and privacy protection are of extreme importance for many of the proposed applications of wireless sensor networks (WSNs). The list of potential applications that require protection mechanisms includes early target tracking and monitoring on a battlefield; law enforcement applications; automotive telemetric applications; room occupation monitoring in office buildings; measuring temperature and pressure in oil pipelines [1]; and forest fire detection. All these applications have unlimited benefits and potential; however, if the sensor information is not protected properly, possible compromises in user information, the environment, and even physical actuators could result. The primary driving impetus for the development of sensor networks has been military applications, where security requirements are at their highest [2]. Although a WSN deployed on a battlefield can offer a reliable assessment of battlefield conditions without risking lives, an inadequately protected network could become a powerful weapon for an enemy. Strong security requirements for such applications are often combined with an inhospitable and physically unprotected environment. For commercial applications of WSNs, the issue of privacy protection is as important as secure and reliable functioning of a network. The protection of personal physiological and psychological information is expected by any user. As the applications of WSNs become more complex and widespread, the ability to protect such systems from any unauthorized access will become increasingly important. Sensor networks operate in a variety of physical environments and under varieties of constraints. The limited resources of sensor nodes require the development of customized system architectures for each particular WSN application so that the sensor node resources are efficiently used. Because security and privacy protection mechanisms require a significant amount of computational and storage resources, Sasha Slijepcevic University of California at Los Angeles
Dynamic Network Delay Cartography (2014)

Path delays in IP networks are important metrics, required by network operators for assessment, planning, and fault diagnosis. Monitoring delays of all source-destination pairs in a large network are, however, challenging and wasteful of resources. This paper advocates a spatio-temporal Kalman filtering approach to construct network-wide delay maps using measurements on only a few paths. The proposed network cartography framework allows efficient tracking and prediction of delays by relying on both topological as well as historical data. Optimal paths for delay measurement are selected in an online fashion by leveraging the notion of submodularity. The resulting predictor is optimal in the class of linear predictors, and outperforms competing alternatives on real-world data sets.
All-angle Negative Refraction of Highly Squeezed Polaritons in Graphene-boron nitride Heterostructures (2017)

Graphene-boron nitride (BN) heterostructures provide a versatile platform to flexibly tune the sign of the group velocity of the hybrid plasmon-phonon-polaritons, enabling all-angle negative refraction between graphene plasmons, BN’s phonon polaritons and their hybrid polaritons.