gebhart/patrepeval huggingface dataset:
Quantum-confined Stark effect of lead halide perovskite quantum dots in a mixed dimensional van der Waals heterostructure (2019)

We demonstrate quantum-confined Stark effect in Perovskite quantum dots by employing a voltage-tunable vertically stacked van der Waals heterostructure with 2D materials. A spectral shift of 10 meV was observed for the exciton peak.
Enantioselective Organocatalytic Amine Conjugate Addition. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Abstract B04: Multimodal cancer immunotherapy combining IL-8 inhibition, adenovirus vaccine, IL-15 super agonist, and anti-PD-L1/TGFβRII agent reduces mesenchymalization and enhances anti-tumor efficacy (2020)

Abstract Tumor cells utilize the secretion of proinflammatory cytokines and chemokines and the surface expression of inhibitory ligands to promote an immune-suppressive tumor microenvironment that facilitates tumor growth and metastasis. The overexpression of IL-8, TGF-β, PD-L1, the IL-8 receptors CXCR1 and CXCR2, as well as numerous other factors by various solid and hematologic cancers are major obstacles in the promotion of a strong and effective antitumor immune response. Both IL-8 and TGF-β have been identified as key potentiators of tumor cell plasticity and the acquisition of mesenchymal features by epithelial cancer cells, i.e., mesenchymalization, which increases metastatic dissemination. Both IL-8 and TGF-β can also promote tumor angiogenesis, myeloid-derived suppressor cell (MDSC) function in the tumor microenvironment, and resistance to immune-mediated killing. Additionally, tumor cell expression of PD-L1 inhibits effective T-cell responses at the tumor site. Here we report the use of a systematic and rational multimodal cancer immunotherapy approach that combines induction of T cell potentiation through an IL-15 super agonist and adenoviral cancer vaccine with inhibition of three immunosuppressive pathways through blockade of IL-8, TGF-β, and PD-L1. Combination of the novel small-molecule inhibitor SX-682 that irreversibly binds and blocks both CXCR1 and CXCR2 with an adenoviral-based cancer vaccine, N-IL15 (previously designated ALT-803), and the anti-PD-L1/TGFβRII agent, M7824, significantly delayed tumor growth in murine models of breast and colon cancer. Mechanistic studies demonstrated that this multimodal combination therapy was able to markedly increase tumor infiltration with CD4+ and CD8+ T cells, including central memory and effector memory subsets, and to decrease infiltration with Ly6G+/Ly6C- MDSC. Studies with SX-682 as a monotherapy suggest that CXCR1/2 inhibition reduces migration rates of Ly6G+/Ly6C- MDSC (CXCR2+). Studies with models of claudin-low, mesenchymal-enriched, human triple-negative breast cancer demonstrated that CXCR1/2 inhibition was also effective at promoting a switch from a mesenchymal to an epithelial tumor phenotype, while simultaneously enhancing the tumor cells’ susceptibility to immune-mediated cytotoxicity. Our results provide rationale for the future evaluation of this multimodal therapy in the clinic. Citation Format: Lucas Horn, Duane Hamilton, Dean Maeda, John Zebala, John Lee, Shahrooz Rabizadeh, Frank Jones, Patrick Soon-Shiong, Zhen Su, Jeffrey Schlom, Claudia Palena. Multimodal cancer immunotherapy combining IL-8 inhibition, adenovirus vaccine, IL-15 super agonist, and anti-PD-L1/TGFβRII agent reduces mesenchymalization and enhances anti-tumor efficacy [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology and Immunotherapy; 2018 Nov 27-30; Miami Beach, FL. Philadelphia (PA): AACR; Cancer Immunol Res 2020;8(4 Suppl):Abstract nr B04.
Extraction of the electric field in field plate assisted RESURF devices (2012)

It has previously been reported that the lateral electric field (E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> ) in the drain extension of thin SOI HV (700V) field plate assisted RESURF devices can be extracted from their I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> -V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> characteristics in the subthreshold regime. In this work the prerequisites for valid field extraction and the (voltage) range of validity are established for linearly graded drain extension based RESURF devices through a combination of analytical calculations and TCAD device modeling. It is shown that the most important condition for field extraction is that an increment dV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DS</sub> should not affect the lateral field at the already depleted zone. This unique condition is found to be met in the drain extension at distances larger than a specific length (5.3λ) governed by the drain extension silicon and oxide thicknesses. For realistic device parameters the method is shown to hold for devices with a BV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DS</sub> of ~ 150V and higher.
Chitoneous Materials for Control of Foodborne Pathogens and Mycotoxins in Poultry (2018)

Public concern with the incidence of antibiotic-resistant bacteria, particularly among foodborne pathogens has been challenging the poultry industry to find alternative means of control. Chitosan is a modified, natural biopolymer derived by deacetylation of chitin. The antimicrobial activity and film-forming property of chitosan makes it a potential source of food preservative or coating material of natural origin for improvement of quality and shelf life of various foods of agriculture, poultry, beef and seafood origin. In addition to its use as an antimicrobial, it has been shown that it has good properties as a mycotoxin adsorbent. The purposes of the present chapter is to summarize our experience using chitin-chitosan from Deacetylated 95% food grade chitosan (Paragon Specialty Products LLC Rainsville, AL) or Aspergillus oryzae meal (Fermacto®, PetAg Inc., Hampshire IL) to control foodborne pathogens, improve performance, biological sanitizer and mycotoxin binder in commercial poultry.
Ebolavirus Δ-Peptide Immunoadhesins Inhibit Marburgvirus and Ebolavirus Cell Entry (2011)

With the exception of Reston and Lloviu viruses, filoviruses (marburgviruses, ebolaviruses, and "cuevaviruses") cause severe viral hemorrhagic fevers in humans. Filoviruses use a class I fusion protein, GP(1,2), to bind to an unknown, but shared, cell surface receptor to initiate virus-cell fusion. In addition to GP(1,2), ebolaviruses and cuevaviruses, but not marburgviruses, express two secreted glycoproteins, soluble GP (sGP) and small soluble GP (ssGP). All three glycoproteins have identical N termini that include the receptor-binding region (RBR) but differ in their C termini. We evaluated the effect of the secreted ebolavirus glycoproteins on marburgvirus and ebolavirus cell entry, using Fc-tagged recombinant proteins. Neither sGP-Fc nor ssGP-Fc bound to filovirus-permissive cells or inhibited GP(1,2)-mediated cell entry of pseudotyped retroviruses. Surprisingly, several Fc-tagged Δ-peptides, which are small C-terminal cleavage products of sGP secreted by ebolavirus-infected cells, inhibited entry of retroviruses pseudotyped with Marburg virus GP(1,2), as well as Marburg virus and Ebola virus infection in a dose-dependent manner and at low molarity despite absence of sequence similarity to filovirus RBRs. Fc-tagged Δ-peptides from three ebolaviruses (Ebola virus, Sudan virus, and Taï Forest virus) inhibited GP(1,2)-mediated entry and infection of viruses comparably to or better than the Fc-tagged RBRs, whereas the Δ-peptide-Fc of an ebolavirus nonpathogenic for humans (Reston virus) and that of an ebolavirus with lower lethality for humans (Bundibugyo virus) had little effect. These data indicate that Δ-peptides are functional components of ebolavirus proteomes. They join cathepsins and integrins as novel modulators of filovirus cell entry, might play important roles in pathogenesis, and could be exploited for the synthesis of powerful new antivirals.
Immunity to Onchocerciasis: Cells from Putatively Immune Individuals Produce Enhanced Levels of Interleukin-5, Gamma Interferon, and Granulocyte-Macrophage Colony-Stimulating Factor in Response toOnchocerca volvulusLarval and Male Worm Antigens (2000)

Antigen-specific interleukin-5 (IL-5), gamma interferon (IFN-gamma), and granulocyte-macrophage colony-stimulating factor (GM-CSF) responses in individuals living in an area of hyperendemicity for onchocerciasis in Cameroon were examined. The responses against antigens prepared from Onchocerca volvulus third-stage larvae (L3), molting L3 (mL3), and crude extract from adult males (M-OvAg) were compared to the responses against antigens from adult female worms and skin microfilariae. Cytokine responses for the putatively immune individuals (PI) and the infected individuals (INF) were compared. A differential cytokine profile of IL-5 (Th2 phenotype) and IFN-gamma (Th1 phenotype) was found in these individuals in response to the antigens. In both the PI and the INF, Th2 responses against all the antigens tested were dominant. However, in the PI group as a whole, there was an enhanced Th2 response against the larval antigens and the adult male and adult female antigens, and a Th1 response in a subgroup of the PI (27 to 54.5%) against L3, mL3, and M-OvAg antigens was present. While the PI produced significantly higher levels of GM-CSF against L3, mL3, and M-OvAg antigens than the INF, there was no difference in the GM-CSF responses of the groups against the other antigens. The present study indicated that, in comparison to the INF, the PI have distinct larva-specific and adult male-specific cytokine responses, thus supporting the premise that immunological studies of the PI would lead to the identification of immune mechanisms and the target genes that play a role in protective immunity.
RNA polymerase. Direct evidence for a unique topographical site for initiation. (1985)

The compound 9-(3'-azido-3'-deoxy-beta-D-xylofuranosyl)adenine 5'-monophosphate is an inhibitor (Ki = 330 microM) of the initiation binding site of the DNA-dependent RNA polymerase derived from Escherichia coli. The alpha-32P derivative of this photo-labile compound is used to derivatize a site on the sigma subunit of the holoenzyme (E sigma) using either T7 delta D111 or poly[d(A-T)] as a DNA template. The incorporation of the 32P label into the sigma subunit could be prevented by the addition of either 5'-AMP or 5'-ATP. The results are suggested to support the existence of a unique initiation binding site, topographically distinct from the sites employed during the elongation phase.
Increasing Prevalence of Metabolic Syndrome in Korea (2011)

Because dyslipidemia and abdominal obesity were major factors in increasing the prevalence of metabolic syndrome in Koreans for the past 10 years, lifestyle interventions should be conducted at the national level to reduce the burden and consequences of metabolic syndrome.
The potential of backscattering interferometry as an in vitro clinical diagnostic tool for the serological diagnosis of infectious disease (2010)

Backscattering interferometry enables the detection of syphilis antibody-antigen interactions in the presence of human serum, showing promise as a diagnostic tool for the serological diagnosis of infectious disease with potentially quantitative capabilities.
Performance of time-frequency localized and frequency selective filter banks in multicarrier systems (2006)

This paper studies filter bank based multicarrier data transmission over wireless mobile channel. A complex modulated filter bank, based on cosine and sine modulated filter banks, is used as a transmultiplexer and a low complexity equalizer called AP-ASCET is used to compensate the channel distortion. At first, various filter bank design criteria are compared and analyzed based on their time-frequency localization (TFL) properties. Then, the system performance is simulated using the ITU-R vehicular-A channel model. TFL measures and uncoded bit error rate (BER) results indicate that even short subchannel filters can provide sufficient performance in narrowband interference-free channel conditions. Furthermore, the filter bank design criterion has only a small effect on the system performance if AP-ASCET approach is used
Near-field ion energy and species measurements of a 5 kW laboratory Hall thruster (1999)

Peer Reviewed
Thermomorphic phase separation in ionic liquid–organic liquid systems—conductivity and spectroscopic characterization (2005)

Electrical conductivity, FT-Raman and NMR measurements are demonstrated as useful tools to probe and determine phase behavior of thermomorphic ionic liquid-organic liquid systems. To illustrate the methods, consecutive conductivity measurements of a thermomorphic methoxyethoxyethyl-imidazolium ionic liquid/1-hexanol system are performed in the temperature interval 25-80 degrees C using a specially constructed double-electrode cell. In addition, FT-Raman and 1H-NMR spectroscopic studies performed on the phase-separable system in the same temperature interval confirm the mutual solubility of the components in the system, the liquid-liquid equilibrium phase diagram of the binary mixture, and signify the importance of hydrogen bonding between the ionic liquid and the hydroxyl group of the alcohol.
О методике настройки векторных систем автоматического управления для серийных преобразователей частоты (2016)

В статье рассматривается методика наладки векторных систем автоматического управления в серийных преобразователях частоты. В качестве примера производится настройка векторной системы управления в преобразователе Sinamics S-120 фирмы Siemens. Приводятся результаты моделирования и экспериментальных исследований на базе лабораторного стенда кафедры. В заключение показана работоспособность предложенной методики для систем электропривода с различным быстродействием и даны рекомендации для практической настройки векторных систем управления.
Learning better image representations using &#x2018;flobject analysis&#x2019; (2011)

Unsupervised learning can be used to extract image representations that are useful for various and diverse vision tasks. After noticing that most biological vision systems for interpreting static images are trained using disparity information, we developed an analogous framework for unsupervised learning. The output of our method is a model that can generate a vector representation or descriptor from any static image. However, the model is trained using pairs of consecutive video frames, which are used to find representations that are consistent with optical flow-derived objects, or `flobjects'. To demonstrate the flobject analysis framework, we extend the latent Dirichlet allocation bag-of-words model to account for real-valued word-specific flow vectors and image-specific probabilistic associations between flow clusters and topics. We show that the static image representations extracted using our method can be used to achieve higher classification rates and better generalization than standard topic models, spatial pyramid matching and gist descriptors.
Orthogonal Extraction (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Des yeux et du regard : proverbes et expressions (2020)

The eyes and the gaze participate in a major way in our non-verbal language, even before the verb appeared. From the Bible to contemporary language, through Greek mythology, theater, literature or spoken language, a multitude of expressions and proverbs present the eye, what it sees and what it symbolizes.
Synthesis of Potent Bicyclic Bisarylimidazole c-Jun N-Terminal Kinase Inhibitors by Catalytic C−H Bond Activation (2006)

The efficient preparation of the privileged bicyclic bisarylimidazole kinase inhibitor scaffold was accomplished using rhodium-catalyzed C−H activation and intramolecular alkylation. The key C−H activation/alkylation step represents one of the first evaluations of diastereocontrol in catalyzed C−H activation/olefin alkylation processes. Several inhibitors of JNK3 were prepared using this sequence, with the most potent inhibitor having an IC50 value of 1.6 nM.
Reproducibility of T1 mapping 11-heart beat MOLLI Sequence (2015)

Methods 15 healthy volunteers (31±5 years, 8 males) with no known medical conditions, on no medication, underwent CMR scans (Avanto, Siemens, 1.5T) on two separate attendances with an 11 heart beat MOLLI 5(3)3. Following frequency adjustment, native T1 maps were obtained twice on a basal and a mid-ventricular slice respectively. 15 mins following GBCA administration (0.1 mmol/kg, Gadobutrol, Bayer, Germany) both image planes were acquired again twice. Pixel-wise T1 maps were analyzed offline by 2 independent blinded operators. A Region Of Interest was manually drawn in the septum for myocardium and blood in native and post gad images as shown in fig 1.
Autoimmune Disorders and Extraintestinal Manifestations in First-degree Familial and Sporadic Inflammatory Bowel Disease (2004)

There was a positive association between IBD status (patient vs control) versus EIM, but not AD. A significant positive association between disease type (familial or sporadic) versus either EIM or AD was not detected.
Data from LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;The identification of pancreatic ductal adenocarcinoma (PDAC) dysregulated genes may unveil novel molecular targets entering inhibitory strategies. Laminins are emerging as potential targets in PDAC given their role as diagnostic and prognostic markers. Here, we investigated the cellular, functional, and clinical relevance of LAMC2 and its regulated network, with the ultimate goal of identifying potential therapies.&lt;/p&gt;Experimental Design:&lt;p&gt;LAMC2 expression was analyzed in PDAC tissues, a panel of human and mouse cell lines, and a genetically engineered mouse model. Genetic perturbation in 2D, 3D, and &lt;i&gt;in vivo&lt;/i&gt; allograft and xenograft models was done. Expression profiling of a LAMC2 network was performed by RNA-sequencing, and publicly available gene expression datasets from experimental and clinical studies examined to query its human relevance. Dual inhibition of pharmacologically targetable LAMC2-regulated effectors was investigated.&lt;/p&gt;Results:&lt;p&gt;LAMC2 was consistently upregulated in human and mouse experimental models as well as in human PDAC specimens, and associated with tumor grade and survival. LAMC2 inhibition impaired cell cycle, induced apoptosis, and sensitized PDAC to MEK1/2 inhibitors (MEK1/2i). A LAMC2-regulated network was featured in PDAC, including both classical and quasi-mesenchymal subtypes, and contained downstream effectors transcriptionally shared by the KRAS signaling pathway. LAMC2 regulated a functional FOSL1–AXL axis via AKT phosphorylation. Furthermore, genetic LAMC2 or pharmacological AXL inhibition elicited a synergistic antiproliferative effect in combination with MEK1/2is that was consistent across 2D and 3D human and mouse PDAC models, including primary patient-derived organoids.&lt;/p&gt;Conclusions:&lt;p&gt;LAMC2 is a molecular target in PDAC that regulates a transcriptional network that unveils a dual drug combination for cancer treatment.&lt;/p&gt;&lt;/div&gt;
Positron Emission Tomographic Studies of the Processing of Singe Words (1989)

PET images of blood flow change that were averaged across individuals were used to identify brain areas related to lexical (single-word) processing, A small number of discrete areas were activated during several task conditions including: modality-specific (auditory or visual) areas activated by passive word input, primary motor and premotor areas during speech output, and yet further areas during tasks making semantic or intentional demands.
No bit left behind (2008)

On one hand, the high cost of memory continues to drive demand for memory efficiency on embedded and general purpose computers. On the other hand, programmers are increasingly turning to managed languages like Java for their functionality, programmability, and reliability. Managed languages, however, are not known for their memory efficiency, creating a tension between productivity and performance. This paper examines the sources and types of memory inefficiencies in a set of Java benchmarks. Although prior work has proposed specific heap data compression techniques, they are typically restricted to one model of inefficiency. This paper generalizes and quantitatively compares previously proposed memorysaving approaches and idealized heap compaction. It evaluates a variety of models based on strict and deep object equality, field value equality, removing bytes that are zero, and compressing fields and arrays with a limited number and range of values. The results show that substantial memory reductions are possible in the Java heap. For example, removing bytes that are zero from arrays is particularly effective, reducing the application's memory footprint by 41% on average.We are the first to combine multiple savings models on the heap, which very effectively reduces the application by up to 86%, on average 58%. These results demonstrate that future work should be able to combine a high productivity programming language with memory efficiency.
ULTRA-WIDEBAND ANTENNA ARRAYS: SYSTEMS WITH TRANSFER FUNCTION AND IMPULSE RESPONSE (2014)

This paper proposes some approaches to model Ultra Wideband (UWB) antenna arrays. Based on the array factor, often stipulated as not adapted for the description of the properties of UWB arrays in the literature, an analytical expression of the beampattern is developed. The achieved results are coherent with other formulations and empiric studies proposed in the literature. Furthermore, a time-frequency modeling of UWB antenna arrays is proposed using the concept of array factor and antenna efiective length.