gebhart/patrepeval huggingface dataset:
Abstract 3651: Caloric Restriction Stimulates Ischemia-induced Angiogenesis through an eNOS-dependent Pathway (2008)

Caloric restriction (CR) can extend longevity and modulate the features of obesity-related metabolic and vascular diseases. However, little is known about the role of CR in the process of ischemia-induced vascular remodeling. Here, we investigated whether CR regulates angiogenic responses in vivo employing the hindlimb model of ischemia-induced angiogenesis. Wild-type (WT), endothelial nitric oxide synthase deficient (eNOS-KO) or adiponectin deficient (APN-KO) mice were randomly divided into 2 groups that were fed either ad libitum (AL) or CR (65% of the diet consumption of AL). Four weeks later, mice were subjected to unilateral hindlimb surgery. Serum adiponectin levels were measured by ELISA. The expression and activation of eNOS were assessed by Western blot analysis. Body weight of WT mice fed CR (CR-WT) was decreased by 26% compared to WT mice fed AL (AL-WT). Angiogenic repair of ischemic hindlimb was accelerated in CR-WT compared with AL-WT as evaluated by laser Doppler blood flow (p&lt;0.05) and capillary density analyses (p&lt;0.05). In WT mice, CR significantly enhanced ischemia-induced increase in eNOS activation of muscle tissues and increased serum adiponectin levels. In eNOS-KO mice, CR significantly increased serum adiponectin levels but did not enhance limb perfusion after surgery. In APN-KO mice, ischemia induction did not increase eNOS activation in muscle tissues, and CR had no effects on blood flow recovery and eNOS activation in ischemic limb. Our observation indicates that CR can promote angiogenesis in response to tissue ischemia through its ability to increase eNOS activation that is possibly mediated by adiponectin.
Supplementary Materials and Methods, Tables 1-2 from Tasisulam Sodium, an Antitumor Agent That Inhibits Mitotic Progression and Induces Vascular Normalization (2023)

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Polymeric materials with enhanced second order nonlinearities (2003)

Electric-field poling of thin polymer films containing dipolar chromophores provides materials possessing significant bulk second-order nonlinear optical susceptibilities. Incorporation of cyanovinyl acceptor groups into the chromophores results in larger susceptibilities than when the more usual nitro group is used. This dye copolymer has been synthesized and processed to yield a novel single-component material with useful, stable bulk hyperpolarizabilities.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
EFFECTS OF DIFFERENT ENKEPHALIN TREATMENTS ON BLADDER PAIN (2008)

You have accessJournal of Urology1 Apr 2008EFFECTS OF DIFFERENT ENKEPHALIN TREATMENTS ON BLADDER PAIN Hitoshi Yokoyama, Chikashi Saitoh, Minoru Miyazato, Osamu Nishizawa, Michael B Chancellor, William F Goins, James R Goss, Joseph C Glorioso, and Naoki Yoshimura Hitoshi YokoyamaHitoshi Yokoyama More articles by this author , Chikashi SaitohChikashi Saitoh More articles by this author , Minoru MiyazatoMinoru Miyazato More articles by this author , Osamu NishizawaOsamu Nishizawa More articles by this author , Michael B ChancellorMichael B Chancellor More articles by this author , William F GoinsWilliam F Goins More articles by this author , James R GossJames R Goss More articles by this author , Joseph C GloriosoJoseph C Glorioso More articles by this author , and Naoki YoshimuraNaoki Yoshimura More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60177-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "EFFECTS OF DIFFERENT ENKEPHALIN TREATMENTS ON BLADDER PAIN." The Journal of Urology, 179(4S), p. 60 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 60 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Hitoshi Yokoyama More articles by this author Chikashi Saitoh More articles by this author Minoru Miyazato More articles by this author Osamu Nishizawa More articles by this author Michael B Chancellor More articles by this author William F Goins More articles by this author James R Goss More articles by this author Joseph C Glorioso More articles by this author Naoki Yoshimura More articles by this author Expand All Advertisement PDF downloadLoading ...
Evidence for the Predominance of Condensed Phase Reaction in Chemical Looping Reactions between Carbon and Oxygen Carriers (2012)

This study investigates the use of metal oxides as an oxygen carrier in chemical looping combustion applications. The initiation and decomposition of C/CuO and C/Fe2O3 are investigated using a time-resolved T-jump/time-of-flight mass spectrometer (T-Jump/TOFMS). Heating of the metal oxide nanopowders produces gaseous O2, but when mixed with the fuel (carbon), gaseous O2 forms temporally after the primary combustion product, CO2. This indicates condensed phase reaction between the metal oxide and carbon as the predominant reaction mechanism rather than gas phase release of O2 and subsequent burning of carbon, at least in the initiation phase. In situ heating TEM, and SEM are used to further investigate the reaction. The oxidation rate of carbon in the present experiment is estimated to be 3 to 5 orders of magnitude greater than that predicted using the Nagle Strickland-Constable model. The activation energy of C/CuO, C/Fe2O3, and C/Bi2O3 are determined using the Ozawa iso-conversion method and are found to be 110, 170, and 230 kJ/mol, respectively. The condensed phase nature of this reaction is compared to our previous studies on aluminum nanothermites and is considered to be further evidence toward a reactive sintering initiation mechanism.
Association of Human FcγRIIa (CD32) Polymorphism with Susceptibility to and Severity of Meningococcal Disease (1998)

Phagocytosis of bacteria constitutes an important defense mechanism against invasive bacterial diseases. Efficacy of phagocytosis by polymorphonuclear neutrophils is known to vary between allotypes of Fc gamma RIIa (a class of Fc receptors for immunoglobulins that is constitutively expressed on neutrophils). We compared the distribution of Fc gamma RIIa-R131 and Fc gamma RIIa-H131 allotypes in 98 Slavic complement-sufficient patients with meningococcal disease with that of the allotypes in 107 healthy controls. A strong association was found between the IIa-R/R131 allotype and the development of meningococcal disease after the age of 5 years, compared with IIa-R/H131 and IIa-H/H131 allotypes (P < .03; odds ratio [OR], 2.9). A severe course of meningococcal disease was observed in 21 (68%) of 31 episodes in patients with IIa-R/R131 genotype and in 22 (54%) of 41 episodes in patients with IIa-R/H131 genotype, in contrast to eight (31%) of 26 episodes in patients with IIa-H/H131 genotype (P < .02; OR, 4.7). Our data show that individuals older than 5 years of age who have the IIa-H/H131 allotype are less susceptible to severe meningococcal disease than are individuals with the IIa-R/R131 or IIa-R/H131 genotype.
Immunotherapy With the PreS-based Grass Pollen Allergy Vaccine BM32 Induces Antibody Responses Protecting Against Hepatitis B Infection (2016)

Our study demonstrates that the recombinant hypoallergenic grass pollen allergy vaccine BM32 induces hepatitis B-specific immune responses which protect against hepatitis B virus infection in vitro.
Fatigue, mood and quality of life improve in MS patients after progressive resistance training (2010)

Fatigue occurs in the majority of multiple sclerosis patients and therapeutic possibilities are few. Fatigue, mood and quality of life were studied in patients with multiple sclerosis following progressive resistance training leading to improvement of muscular strength and functional capacity. Fatigue (Fatigue Severity Scale, FSS), mood (Major Depression Inventory, MDI) and quality of life (physical and mental component scores, PCS and MCS, of SF36) were scored at start, end and follow-up of a randomized controlled clinical trial of 12 weeks of progressive resistance training in moderately disabled (Expanded Disability Status Scale, EDSS: 3-5.5) multiple sclerosis patients including a Control group (n = 15) and an Exercise group (n = 16). Fatigue (FSS > 4) was present in all patients. Scores of FSS, MDI, PCS-SF36 and MCS-SF36 were comparable at start of study in the two groups. Fatigue improved during exercise by -0.6 (95% confidence interval (CI) -1.4 to 0.4) a.u. vs. 0.1 (95% CI -0.4 to 0.6) a.u. in controls (p = 0.04), mood improved by -2.4 (95% CI -4.1 to 0.7) a.u. vs. 1.1 (-1.2 to 3.4) a.u. in controls (p = 0.01) and quality of life (PCS-SF36) improved by 3.5 (95% CI 1.4-5.7) a.u. vs. -1.0 (95% CI -3.4-1.4) a.u. in controls (p = 0.01). The beneficial effect of progressive resistance training on all scores was maintained at follow-up after further 12 weeks. Fatigue, mood and quality of life all improved following progressive resistance training, the beneficial effect being maintained for at least 12 weeks after end of intervention.
Bioengineering the Oxygen-Deprived Tumor Microenvironment Within a Three-Dimensional Platform for Studying Tumor-Immune Interactions (2020)

Oxygen deprivation within tumors is one of the most prevalent causes of resilient cancer cell survival and increased immune evasion in breast cancer (BCa). Current <i>in vitro</i> models do not adequately mimic physiological oxygen levels relevant to breast tissue and its tumor-immune interactions. In this study, we propose an approach to engineer a three-dimensional (3D) model (named 3D engineered oxygen, 3D-O) that supports the growth of BCa cells and generates physio- and pathophysiological oxygen levels to understand the role of oxygen availability in tumor-immune interactions. BCa cells (MDA-MB-231 and MCF-7) were embedded into plasma-derived 3D-O scaffolds that reflected physio- and pathophysiological oxygen levels relevant to the healthy and cancerous breast tissue. BCa cells grown within 3D-O scaffolds were analyzed by flow cytometry, confocal imaging, immunohistochemistry/immunofluorescence for cell proliferation, extracellular matrix protein expression, and alterations in immune evasive outcomes. Exosome secretion from 3D-O scaffolds were evaluated using the NanoSight particle analyzer. Peripheral blood mononuclear cells were incorporated on the top of 3D-O scaffolds and the difference in tumor-infiltrating capabilities as a result of different oxygen content were assessed by flow cytometry and confocal imaging. Lastly, hypoxia and Programmed death-ligand 1 (PD-L1) inhibition were validated as targets to sensitize BCa cells in order to overcome immune evasion. Low oxygen-induced adaptations within 3D-O scaffolds validated known tumor hypoxia characteristics such as reduced BCa cell proliferation, increased extracellular matrix protein expression, increased extracellular vesicle secretion and enhanced immune surface marker expression on BCa cells. We further demonstrated that low oxygen in 3D-O scaffolds significantly influence immune infiltration. CD8+ T cell infiltration was impaired under pathophysiological oxygen levels and we were also able to establish that hypoxia and PD-L1 inhibition re-sensitized BCa cells to cytotoxic CD8+ T cells. Bioengineering the oxygen-deprived BCa tumor microenvironment in our engineered 3D-O physiological and tumorous scaffolds supported known intra-tumoral hypoxia characteristics allowing the study of the role of oxygen availability in tumor-immune interactions. The 3D-O model could serve as a promising platform for the evaluation of immunological events and as a drug-screening platform tool to overcome hypoxia-driven immune evasion.
Real-Time Large-Scale Map Matching Using Mobile Phone Data (2017)

With the wide spread use of mobile phones, cellular mobile big data is becoming an important resource that provides a wealth of information with almost no cost. However, the data generally suffers from relatively high spatial granularity, limiting the scope of its application. In this article, we consider, for the first time, the utility of actual mobile big data for map matching allowing for “microscopic” level traffic analysis. The state-of-the-art in map matching generally targets GPS data, which provides far denser sampling and higher location resolution than the mobile data. Our approach extends the typical Hidden-Markov model used in map matching to accommodate for highly sparse location trajectories, exploit the large mobile data volume to learn the model parameters, and exploit the sparsity of the data to provide for real-time Viterbi processing. We study an actual, anonymised mobile trajectories data set of the city of Dakar, Senegal, spanning a year, and generate a corresponding road-level traffic density, at an hourly granularity, for each mobile trajectory. We observed a relatively high correlation between the generated traffic intensities and corresponding values obtained by the gravity and equilibrium models typically used in mobility analysis, indicating the utility of the approach as an alternative means for traffic analysis.
Exciting Localized Modes in Polar Epsilon-Near-Zero Materials (2017)

We design, fabricate and characterize nanoantennas on epsilon-near-zero polar thin films. Reflection measurements and simulations indicate a localized mode at 11.2 μm that has a strong electric field in the AlN epsilon-near-zero film.
Spectrophotometric color matching based on two‐constant kubelka‐munk theory (1988)

Abstract An algorithm is proposed to minimize the spectral difference between the reflectance of a standard and that of a match formed from a mixture of scattering colorants. This method applies linear least‐squares techniques and Kubelka‐Munk two‐constant theory to the calculation of colorant concentrations required to match the K/S curve of a standard. Several advantages may be gained over traditional tristimulus matching: the spectral reflectance of the standard and predicted formulation exhibit lower spectral difference, the use of spectrally similar colorants is enhanced, and formulations can be determined for standards measured over wavelength regions other than the visible spectrum.
Active demultiplexing of single photons from a solid‐state source (Laser Photonics Rev. 11(3)/2017) (2017)

Single photons from a solid state source are deterministically routed into different output modes by a fully integrated active optical switch network. Using a state-of-the-art single photon source made of a single quantum dot in a micropillar cavity and an innovative integrated optical demultiplexer, this scheme is capable of creating manifold single photon states. Such states are a crucial resource for photonic quantum information applications including linear optics quantum computation and quantum communications. (Picture: Mirko Lobino, Ph.D. et al., article number 1600297, in this issue)
Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma: CALGB 500104 (2006)

8014 Background: Ras-based signaling is thought to be critical in the genesis of melanoma. Farneslytransferase (FT) inhibitors (FTIs) have been developed as a pharmacologic strategy to inhibit Ras function. Additional farnesylated proteins are also important for the malignant process, and FTIs inhibit melanoma cell line proliferation in vitro. These considerations motivated the development of a phase II trial of the FTI R115777 in patients with melanoma. Farnesylated proteins are also important for T cell activation. The interest in future combinations of targeted agents and immunotherapeutics in this disease prompted analysis of T cell function ex vivo. Methods: A 3-stage design was pursued with a maximum of 40 patients planned and early stopping if there were no responders in the first 14, or fewer than 2 responders in the first 28 patients. Eligibility included intact organ function, PS≤1, no prior chemotherapy, at most 1 prior immunotherapy, no brain metastases, and presence of at least 2 cutaneous lesions amenable to excisional biopsy. R115777 (300 mg orally) was administered twice per day for 21 days of a 28-day cycle. Patients were evaluated every 2 cycles by RECIST criteria. Blood was obtained pre-treatment and during week 7 for analysis of HDJ-2 farnesylation and for T cell IFN-γ production in response to SEA. In addition, tumor biopsies were performed pre- and post-treatment when feasible to directly measure FT activity. Results: 14 patients were enrolled. 2 patients had grade 3 toxicities, which included myelosuppression, nausea/vomiting, elevated BUN, and anorexia. There were no clinical responses, and only 4 patients went on to a second course of treatment. All analyzed patients showed HDJ-2 gel shift in peripheral blood cells, as well as marked inhibition of FT activity (by 85–98%) in tumor tissue. T cell production of IFN-γ was also suppressed. Conclusions: Despite potent target inhibition, the FTI R115777 showed no evidence for clinical activity as a single agent in this cohort of 14 metastatic melanoma patients. Inhibition of T cell function has implications for future combination therapies and suggests the possibility for FTIs as candidate immunosuppressive agents. New therapeutic approaches for melanoma, or logically selected combination therapies, are needed. [Table: see text]
Energy bandgap dependence of three-photon absorption in semiconductors (2007)

The bandgap and wavelength scaling of three-photon absorption (3PA) is studied in several semiconductors by the Z-scan technique. The 3PA coefficient is found to vary as Eg-7 as predicted by theory. © 2007 Optical Society of America.
Comparison of Algorithms for Anomaly Detection in Flight Recorder Data of Airline Operations (2012)

In order to improve the current high level of safety in air carrier operations, there is increasing emphasis on developing proactive safety management systems to identify and mitigate risk areas before they manifest in aircraft accidents or incidents. One way to conduct proactive safety management for airline operations is to utilize the operational data archived in modern Flight Data Recorders (FDRs) equipped on aircraft. Recently, efforts have been made to develop algorithms to detect anomalies in sensor data from a complex engineered system in a dynamic operating environment. 1 These algorithms take a data-driven approach to build a model for detecting anomalies directly from data collected during system operation, rather than building it based on domain knowledge, standard operating procedure or human expertise. The knowledge discovery processes, in general, face the challenge of validating new discoveries from real-world data as in many cases there exists no “ground truth” that can confirm the presence of these anomalies. In this study, we compared two data-driven anomaly detection algorithms and contrasted the two datadriven methods with the traditional flight data analysis method Exceedance Detection. The two datadriven anomaly detection algorithms are Cluster-based Anomaly Detection (ClusterAD) and Multiple Kernel Anomaly Detection (MKAD). Both algorithms were developed to detect anomalous flights in recorded flight data. The Exceedance Detection method is a Flight Operational Quality Assurance (FOQA) analysis tool widely used in the airline industry. It detects exceedance events when certain flight parameters exceed pre-specified thresholds. Only known safety concerns are examined by this method. All three methods were independently tested on the same set of flight data from an airline’s normal operations. The entire dataset contains recorded flight data of a narrow-body aircraft. The data are from short to medium range flights of a commercial passenger jet airline. The comparison results of the three
Supplemental Data legends from Phase I and Preliminary Phase II Study of TRC105 in Combination with Sorafenib in Hepatocellular Carcinoma (2023)

&lt;p&gt;Supplemental Data legends&lt;/p&gt;
ALK-transformed mature T lymphocytes restore early thymus progenitor features (2020)

Anaplastic large cell lymphoma (ALCL) is a mature T cell neoplasm that often expresses the CD4+ T cell surface marker. It usually harbors the t(2;5) (p23;q35) translocation, leading to the ectopic expression of NPM-ALK, a chimeric tyrosine kinase. We demonstrated that in vitro transduction of normal human CD4+ T lymphocytes with NPM-ALK results in their immortalization and malignant transformation. The tumor cells displayed morphological and immunophenotypical characteristics of primary patient-derived anaplastic large cell lymphomas. Cell growth, proliferation, and survival were strictly dependent on NPM-ALK activity and include activation of the key factors STAT3 and DNMT1 and expression of CD30 (the hallmark of anaplastic large-cell lymphoma). Implantation of NPM-ALK-transformed CD4+ T lymphocytes into immunodeficient mice resulted in the formation of tumors indistinguishable from patients' anaplastic large cell lymphomas. Integration of "Omic" data revealed that NPM-ALK-transformed CD4+ T lymphocytes and primary NPM-ALK+ ALCL biopsies share similarities with early T cell precursors. Of note, these NPM-ALK+ lymphoma cells overexpress stem cell regulators (OCT4, SOX2, and NANOG) and HIF2A, which is known to affect hematopoietic precursor differentiation and NPM-ALK+ cell growth. Altogether, for the first time our findings suggest that NPM-ALK could restore progenitor-like features in mature CD30+ peripheral CD4+ T cells, in keeping with a thymic progenitor-like pattern.
Comparative analysis of ceramide structural modification found in fungal cerebrosides by electrospray tandem mass spectrometry with low energy collision‐induced dissociation of Li adduct ions (2000)

Fungal cerebrosides (monohexosylceramides, or CMHs) exhibit a number of ceramide structural modifications not found in mammalian glycosphingolipids, which present additional challenges for their complete characterization. The use of Li+ cationization, in conjunction with electrospray ionization mass spectrometry and low energy collision-induced dissociation tandem mass spectrometry (ESI-MS/CID-MS), was found to be particularly effective for detailed structural analysis of complex fungal CMHs, especially minor components present in mixtures at extremely low abundance. A substantial increase in both sensitivity and fragmentation was observed on collision-induced dissociation of [M + Li]+ versus [M + Na]+ of the same CMH components analyzed under similar conditions. The effects of particular modifications on fragmentation were first systematically evaluated by analysis of a wide variety of standard CMHs expressing progressively more functionalized ceramides. These included bovine brain galactocerebrosides with non-hydroxy and 2-hydroxy fatty N-acylation; a plant glucocerebroside having (E/Z)-Δ8 in addition to (E)-Δ4 unsaturation of the sphingoid base; and a pair of fungal cerebrosides known to be further modified by a branching 9-methyl group on the sphingoid moiety, and to have a 2-hydroxy fatty N-acyl moiety either fully saturated or (E)-Δ3 unsaturated. The method was then applied to characterization of both major and minor components in CMH fractions from a non-pathogenic mycelial fungus, Aspergillus niger; and from pathogenic strains of Candida albicans (yeast form); three Cryptococcus spp. (all yeast forms); and Paracoccidioides brasiliensis (both yeast and mycelium forms). The major components of all species examined differed primarily (and widely) in the level of 2-hydroxy fatty N-acyl Δ3 unsaturation, but among the minor components a significant degree of additional structural diversity was observed, based on differences in sphingoid or N-acyl chain length, as well as on the presence or absence of the sphingoid Δ8 unsaturation or 9-methyl group. Some variants were isobaric, and were not uniformly present in all species, affirming the need for MS/CID-MS analysis for full characterization of all components in a fungal CMH fraction. The diversity in ceramide distribution observed may reflect significant species-specific differences among fungi with respect to cerebroside biosynthesis and function. Copyright © 2000 John Wiley & Sons, Ltd.