gebhart/patrepeval huggingface dataset:
Mass and energy selective ion partitioning in a two-section Fourier-transform ion cyclotron resonance spectrometer cell (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMass and energy selective ion partitioning in a two-section Fourier-transform ion cyclotron resonance spectrometer cellEric L. Kerley and David H. RussellCite this: Anal. Chem. 1989, 61, 1, 53–57Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/ac00176a012https://doi.org/10.1021/ac00176a012research-articleACS PublicationsRequest reuse permissionsArticle Views32Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Incentives in Core-Selecting Auctions (2006)

A “core-selecting auction mechanism ” is a direct mechanism for a multi-item allocation problem that selects a core allocation with respect to the bidders’ reported values and the auctioneer’s exogenously given preferences. For every profile of others ’ reports, a bidder has a best reply that is a truncation report. For every “bidder optimal ” core imputation, there exists a profile of truncation reports that is a full-information Nash equilibrium for every core-selecting auction with those payoffs. Among core-selecting auctions, the incentives to deviate from truthful reporting are minimal at every preference profile if and only if the auction always selects a bidder optimal allocation with respect to the reported preferences. Finally, a core-selecting auction that selects a minimum revenue core allocation is a bidder optimal auction and make the seller’s revenue a non-decreasing function of the bids, which eliminates distortions that can otherwise occur in the process of bidder application and qualification. All these results have analogues in two-sided matching theory.
A Graph Theoretic Approach for Training Overhead Reduction in FDD Massive MIMO Systems (2018)

The overheads associated with feedback-based channel acquisition can greatly compromise the achievable rates of FDD based massive MIMO systems. Indeed, downlink (DL) training and uplink (UL) feedback overheads scale linearly with the number of base station (BS) antennas, in sharp contrast to TDD-based massive MIMO, where a single UL pilot trains the whole BS array. In this work, we propose a graph-theoretic approach to reducing DL training and UL feedback overheads in FDD massive MIMO systems. In particular, we consider a single-cell scenario involving a single BS with a massive antenna array serving to single-antenna mobile stations (MSs) in the DL. We assume the BS employs two-stage beamforming in the DL, comprising DFT pre-beamforming followed by MU-MIMO precoding. The proposed graph-theoretic approach exploits knowledge of the angular spectra of the BS-MS channels to construct DL training protocols with reduced overheads. Simulation results reveal that the proposed training-resources allocation method can provide approximately 35% sum-rate performance gain compared to conventional orthogonal training. Our analysis also sheds light into the impact of overhead reduction on channel estimation quality, and, in turn, achievable rates.
Open‐Cell Aluminum Foams by the Sponge Replication Technique: A Starting Powder Particle Study (2020)

Open‐cell aluminum foams are manufactured by a sponge replication technique, and the effect of aluminum particles with different shapes and particle sizes on foam properties is studied. It is found that aluminum powder with spheroidal particles leads to aluminum foams with a lower strut porosity, a lower amount of alumina, and a higher compressive strength compared with foams manufactured from flaky, irregularly shaped aluminum powder. This effect is explained with the lower surface area of the first mentioned type of powder.
Low-voltage organic field-effect transistors for flexible electronics (2014)

A process for the fabrication of bottom-gate, top-contact (inverted staggered) organic thin-film transistors (TFTs) with channel lengths as short as 1 μm on flexible plastic substrates has been developed. The TFTs employ vacuum-deposited small-molecule semiconductors and a low-temperature-processed gate dielectric that is sufficiently thin to allow the TFTs to operate with voltages of about 3 V. The p-channel TFTs have an effective field-effect mobility of about 1 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /Vs, an on/off ratio of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sup> , and a signal propagation delay (measured in 11-stage ring oscillators) of 300 ns per stage. For the n-channel TFTs, an effective field-effect mobility of about 0.06 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /Vs, an on/off ratio of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> , and a signal propagation delay of 17 μs per stage have been obtained.
The emerging therapeutic potential of the oncolytic immunotherapeutic Pexa-Vec (JX-594) (2015)

Oncolytic immunotherapeutics (OIs) are viruses designed to preferentially replicate in and lyse cancer cells, thereby triggering antitumor immunity. Numerous oncolytic platforms are currently in clinical development. Here we review preclinical and clinical experience with Pexa-Vec (pexastimogene devacirepvec, JX-594). Pexa-Vec is derived from a vaccinia vaccine strain that has been engineered to target cancer cells and express the therapeutic transgene granulocyte macrophage colony-stimulating factor (GM-CSF) in order to stimulate antitumor immunity. Key to its ability to target metastatic disease is the evolution of unique vaccinia virus characteristics that allow for effective systemic dissemination. Multiple mechanisms of action (MOA) for Pexa-Vec have been demonstrated in preclinical models and patients: 1) tumor cell infection and lysis, 2) antitumor immune response induction, and 3) tumor vascular disruption. This review will summarize data on the Pexa-Vec MOA as well as provide an overview of the Pexa-Vec clinical development program from multiple Phase I studies, Phase II studies in renal cell cancer and colorectal cancer, through Phase IIb clinical testing in patients with advanced hepatocellular carcinoma (primary liver cancer).
Lithium Sulfide Cathodes: A Hierarchical Particle–Shell Architecture for Long‐Term Cycle Stability of Li2S Cathodes (Adv. Mater. 37/2015) (2015)

Hierarchical Li2S–carbon-nanocomposite particles are synthesized by G. Yushin and co-workers, as described on page 5579, using a simple solution-based method followed by vapor deposition. The multiscale and multilevel protection enabled by the proposed architecture prevents mechanical degradation and polysulfide dissolution in lithium–sulfur batteries. The proposed hierarchical particle–shell design can be effectively utilized for a variety of other conversion-type cathode materials.
Data from Depletion of Peripheral Macrophages and Brain Microglia Increases Brain Tumor Titers of Oncolytic Viruses (2023)

&lt;div&gt;Abstract&lt;p&gt;Clinical trials have proven oncolytic virotherapy to be safe but not effective. We have shown that oncolytic viruses (OV) injected into intracranial gliomas established in rodents are rapidly cleared, and this is associated with up-regulation of markers (CD68 and CD163) of cells of monocytic lineage (monocytes/microglia/macrophages). However, it is unclear whether these cells directly impede intratumoral persistence of OV through phagocytosis and whether they infiltrate the tumor from the blood or the brain parenchyma. To investigate this, we depleted phagocytes with clodronate liposomes (CL) &lt;i&gt;in vivo&lt;/i&gt; through systemic delivery and &lt;i&gt;ex vivo&lt;/i&gt; in brain slice models with gliomas. Interestingly, systemic CL depleted over 80% of peripheral CD163&lt;sup&gt;+&lt;/sup&gt; macrophages in animal spleen and peripheral blood, thereby decreasing intratumoral infiltration of these cells, but CD68&lt;sup&gt;+&lt;/sup&gt; cells were unchanged. Intratumoral viral titers increased 5-fold. In contrast, &lt;i&gt;ex vivo&lt;/i&gt; CL depleted only CD68&lt;sup&gt;+&lt;/sup&gt; cells from brain slices, and intratumoral viral titers increased 10-fold. These data indicate that phagocytosis by both peripheral CD163&lt;sup&gt;+&lt;/sup&gt; and brain-resident CD68&lt;sup&gt;+&lt;/sup&gt; cells infiltrating tumor directly affects viral clearance from tumor. Thus, improved therapeutic efficacy may require modulation of these innate immune cells. In support of this new therapeutic paradigm, we observed intratumoral up-regulation of CD68&lt;sup&gt;+&lt;/sup&gt; and CD163&lt;sup&gt;+&lt;/sup&gt; cells following treatment with OV in a patient with glioblastoma. [Cancer Res 2007;67(19):9398–406]&lt;/p&gt;&lt;/div&gt;
Supplementary Figures and Tables from Imaging of Esophageal Lymph Node Metastases by Desorption Electrospray Ionization Mass Spectrometry (2023)

&lt;p&gt;Table S1: Glycerophospholipid relative abundances compared between lymph node metastases (LNM) and primary tumor by means of ANOVA. Table S2: Glycerophospholipid relative abundances compared between malignant tissue (lymph node metastases and primary tumor) and non-malignant lymph node tissue types by means of ANOVA. Table S3: Contingency table comparing immunohistochemistry reference test and mass spectrometry image tissue classification prediction images. Table S4: Contingency Table comparing immunohistochemistry reference test and mass spectrometry image tissue classification prediction images (TCPI) - with re-classification of positive capsular identification on TCPI as normal lymph nodes. Figure S1: DESI-MS of normal lymph node with carbon deposits from smoking. Figure S2: DESI-MS of lymph node with macro-metastases. Figure S3: Internal cross validation - lipidomic profile of lymph node metastases versus lymph node metastases response to chemotherapy. Figure S4: Mass spectrometry image tissue classification prediction images compared to matched AE1/AE3 immunohistochemistry images of 90 lymph node (LN) data set. Figure S5: DESI-MS of mouse brain cryo-section with a spatial resolution of 20μm per pixel. Figure S6: DESI-MS of mouse brain cryo-section with a spatial resolution of 75μm and 30 scans per second. Supplementary Figure S7: Image alignment of histology image and Mass Spectrometry Image (MSI) for tissue specific pixel labeling. Supplementary Figure S8: Overview for the creation of a composite database of tissue specific mass spectra. Tissue specific mass spectra extracted from representative pixels of Mass Spectrometry Images from individual samples are used to populate combined data units of that tissue type with further sub-classification of its sample origin.&lt;/p&gt;
Phosphorescent Blue Organic Light-Emitting Diodes with New Bipolar Host Materials (2012)

We report narrow band gap bipolar host materials, CbPr-3 (9,9'-[(3,3'-Biphenyl-3.3'-yl-bipyridine)-1,3-biphenyl]bis-9H-carbazole) and Bim-4 (9,9'-[5-(1-phenyl-1H-benzimadazol-2yl)-1,3-phenylene] bis-9H-carbazole), for blue phosphorescent OLEDs application. These two bipolar hosts have high triplet energy of > 2.9 eV, capable of reducing the driving voltages and improving efficiencies. Significant low driving voltages of 7.4 and 6.6 V were obtained for CbPr-3 and Bim-4 hosts, compared with 9.0 V of the commonly used host, mCP (1,3-bis(9-carbazolyl)benzene). At a given constant luminance of 1000 cd/m2, the power efficiency of both the bipolar host devices was enhanced by 2.5 times.
Application of photoelectron spectroscopy to biologically active molecules and their constituent parts IV. Methylnitroimidazoles (1979)

Abstract Photoelectron (PE) spectra of imidazole ( 1), 1 ‐methylimidazole ( 2 ), 2‐methylimidazole ( 3 ), 4(5)‐nitroimidazole ( 4 ), 2‐methyl‐4(5)nitroimidazole ( 5 ), 1,2‐dimethyl‐5‐nitroimidazole ( 6 ), 1‐ethyl‐2‐methyl‐5‐nitroimidazole ( 7 ), 1‐bromoethyl‐2‐methyl‐5‐nitroimidazole ( 8 ) and 1‐hydroxyethyl‐2‐methyl‐5‐nitroimidazole ( 9 ) have been recorded using Hel excitation. The electronic structure of the potent antitrichomonal agent 9 is discussed in comparison with compounds 1–8 allowing for the study of the influence of substituents on the imidazole ring.
ChemInform Abstract: A New Analogue of Rocaglamide by an Oxidative Dihydrofuran Synthesis. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Downregulation of Survivin contributes to cell-cycle arrest during postnatal cardiac development in a severe spinal muscular atrophy mouse model (2017)

Spinal muscular atrophy (SMA) is the leading genetic cause of infant mortality, characterized by progressive degeneration of spinal-cord motor neurons, leading to atrophy of skeletal muscles. However, accumulating evidence indicates that it is a multi-system disorder, particularly in its severe forms. Several studies delineated structural and functional cardiac abnormalities in SMA patients and mouse models, yet the abnormalities have been primarily attributed to autonomic dysfunction. Here, we show in a severe mouse model that its cardiomyocytes undergo G0/G1 cell-cycle arrest and enhanced apoptosis during postnatal development. Microarray and real-time RT-PCR analyses revealed that a set of genes associated with cell cycle and apoptosis were dysregulated in newborn pups. Of particular interest, the Birc5 gene, which encodes Survivin, an essential protein for heart development, was down-regulated even on pre-symptomatic postnatal day 0. Interestingly, cultured cardiomyocytes depleted of SMN recapitulated the gene expression changes including downregulation of Survivin and abnormal cell-cycle progression; and overexpression of Survivin rescued the cell-cycle defect. Finally, increasing SMN in SMA mice with a therapeutic antisense oligonucleotide improved heart pathology and recovered expression of deregulated genes. Collectively, our data demonstrate that the cardiac malfunction of the severe SMA mouse model is mainly a cell-autonomous defect, caused by widespread gene deregulation in heart tissue, particularly of Birc5, resulting in developmental abnormalities through cell-cycle arrest and apoptosis.
Pattern Formation in Ultrathin Films of a Novel Dimethylsiloxane−Acrylate Triblock Copolymer (2003)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTPattern Formation in Ultrathin Films of a Novel Dimethylsiloxane−Acrylate Triblock CopolymerJoong Tark Han and Kilwon ChoView Author Information Department of Chemical Engineering, Polymer Research Institute, Pohang University of Science and Technology, Pohang 790-784, Korea Cite this: Macromolecules 2003, 36, 23, 8902–8905Publication Date (Web):October 22, 2003Publication History Received3 July 2003Revised14 August 2003Published online22 October 2003Published inissue 1 November 2003https://pubs.acs.org/doi/10.1021/ma034930phttps://doi.org/10.1021/ma034930pbrief-reportACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views215Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Copolymers,Dewetting,Self organization,Thickness,Thin films Get e-Alerts
Structures of Apurinic and Apyrimidinic Sites in Duplex DNAs (1998)

Natural and exogenous processes can give rise to abasic sites with either a purine or pyrimidine as the base on the opposing strand. The solution state structures of the apyrimidinic DNA duplex, with D6 indicating an abasic site, [sequence: see text] referred to as AD, and the apurinic DNA duplex with a dC17, referred to as CD, have been determined. A particularly striking difference is that the abasic site in CD is predominantly a beta hemiacetal, whereas in AD the alpha and beta forms are equally present. Hydrogen bonding with water by the abasic site and the base on the opposite strand appears to play a large role in determining the structure near the damaged site. Comparison of these structures with that of a duplex DNA containing a thymine glycol at the same position as the abasic site and with that of a duplex DNA containing an abasic site in the middle of a curved DNA sequence offers some insight into the common and distinct structural features of damaged DNA sites.
A 0.5 &amp;mu;m fully scaled two-level metal fully planarized interconnect structure fabricated with X-ray lithography (1990)

A fully planarized two-level-metal structure has been successfully fabricated at 0.5 μm groundrules with the use of X-ray lithography at all processing levels. A 0.5-μm minimum feature size was required for all levels, including the second-level metal. Planarized PECVD oxide and PECVD nitride were employed as dual dielectric layers below M1 and M2. Chemical vapor deposition (CVD) W studs formed by W etchback served as vertical connections for interlevel vias and contacts. All ten lithography patterning steps were performed with X-ray exposures to determine what possible implications this emerging technology might have on the implementation of the interconnect levels
Dynamic Range of Frequency Modulated Direct-Detection Analog Fiber Optic Links (2009)

A frequency modulated (FM) analog optical link using an FM discriminator is analyzed. Figures-of-merit are derived, including expressions for the second-order (OIP2) and third-order intercept points (OIP3), spurious-free dynamic range (SFDR) and noise figure (NF). It is found that a discriminator with linear field transmission and constant group delay will produce no third-order or higher-order distortions, and balanced detection will suppress the remaining second-order distortion. Low biasing the discriminator is found not to improve the NF of the link. Residual intensity modulation (IM) of the laser is shown to significantly increase the link's distortion. A discriminator using tenth-order finite-impulse response (FIR) filters implemented in planar lightwave circuits (PLC) is proposed and shown to improve OIP3 by 31 dB over a Mach-Zehnder interferometer (MZI) discriminator.
Elevated CXC chemokines in urine noninvasively discriminate OAB from UTI (2016)

Overlapping symptoms of overactive bladder (OAB) and urinary tract infection (UTI) often complicate the diagnosis and contribute to overprescription of antibiotics. Inflammatory response is a shared characteristic of both UTI and OAB and here we hypothesized that molecular differences in inflammatory response seen in urine can help discriminate OAB from UTI. Subjects in the age range of (20-88 yr) of either sex were recruited for this urine analysis study. Urine specimens were available from 62 UTI patients with positive dipstick test before antibiotic treatment. Six of these patients also provided urine after completion of antibiotic treatment. Subjects in cohorts of OAB (n = 59) and asymptomatic controls (n = 26) were negative for dipstick test. Urinary chemokines were measured by MILLIPLEX MAP Human Cytokine/Chemokine Immunoassay and their association with UTI and OAB was determined by univariate and multivariate statistics. Significant elevation of CXCL-1, CXCL-8 (IL-8), and CXCL-10 together with reduced levels for a receptor antagonist of IL-1A (sIL-1RA) were seen in UTI relative to OAB and asymptomatic controls. Elevated CXCL-1 urine levels predicted UTI with odds ratio of 1.018 and showed a specificity of 80.77% and sensitivity of 59.68%. Postantibiotic treatment, reduction was seen in all CXC chemokines with a significant reduction for CXCL-10. Strong association of CXCL-1 and CXCL-10 for UTI over OAB indicates mechanistic differences in signaling pathways driving inflammation secondary of infection in UTI compared with a lack of infection in OAB. Urinary chemokines highlight molecular differences in the paracrine signaling driving the overlapping symptoms of UTI and OAB.
Continuous Face Aging via Self-estimated Residual Age Embedding (2021)

Face synthesis, including face aging, in particular, has been one of the major topics that witnessed a substantial improvement in image fidelity by using generative adversarial networks (GANs). Most existing face aging approaches divide the dataset into several age groups and leverage group-based training strategies, which lacks the ability to provide fine-controlled continuous aging synthesis in nature. In this work, we propose a unified network structure that embeds a linear age estimator into a GAN-based model, where the embedded age estimator is trained jointly with the encoder and decoder to estimate the age of a face image and provide a personalized target age embedding for age progression/regression. The personalized target age embedding is synthesized by incorporating both personalized residual age embedding of the current age and exemplar-face aging basis of the target age, where all preceding aging bases are derived from the learned weights of the linear age estimator. This formulation brings the unified perspective of estimating the age and generating personalized aged face, where self-estimated age embeddings can be learned for every single age. The qualitative and quantitative evaluations on different datasets further demonstrate the significant improvement in the continuous face aging aspect over the state-of-the-art.
Draft Genome Sequence of Campylobacter jejuni 11168H (2017)

Campylobacter jejuni is the most prevalent cause of food-borne gastroenteritis in the developed world. The reference and original sequenced strain C. jejuni NCTC11168 has low levels of motility compared to clinical isolates. Here, we describe the draft genome of the laboratory derived hypermotile variant named 11168H.