gebhart/patrepeval huggingface dataset:
P–459 Ex vivo perfusion of whole ewe ovaries with follicular maturation for up to seven days: towards the development of an alternative fertility preservation method (2021)

Abstract Study question To develop an alternative fertility preservation method for young female cancer patients based on an ex vivo perfusion of whole ovaries serving as a platform for future ovarian stimulation studies. Summary answer It is possible to maintain viable follicles and to retrieve oocytes after ex vivo perfusion of ewe ovaries for up to 7 days. What is known already Some progress has been made in terms of follicular growth and the isolation of mature oocytes in vitro. However, full development, from early follicular stages to a viable offspring, has only been described in rodent models. The complex events controlling follicular expansion and the long time required for folliculogenesis and oocyte maturity in large mammalian species creating challenges and limitations for in vitro studies. Ex vivo perfusion of a whole ovary could potentially be a solution by exploiting the intact ovarian architecture to support folliculogenesis and oocyte maturation. Study design, size, duration Thirty-one ewe ovaries were divided into 4 groups and ex vivo perfused in a bioreactor. Group 1 (n = 14) perfusion for 48 hours with no hormone supplementation; Group 2 (n = 4) perfusion 96–101 hours with follicle stimulating hormone (FSH); Group 3 (n = 3) perfusion 120–168 hours with human menopausal gonadotropin (hMG); Group 4 (n = 10) perfusion 72–144 hours with hMG. Participants/materials, setting, methods Ewe ovaries from sexually mature ewes were ex vivo perfused in a bioreactor under normothermic conditions for up to 7 days (max total 168 hours). Histomorphological, immunohistochemical, hormonal and biochemical analyses were performed to assess ovarian structure and viability after cold ischemia and after perfusion which was subsequently compared to control ovaries. Main results and the role of chance The perfused ovaries in group 2 and 3 showed no significant differences in follicular density, viability and oocyte quality after ischemia and perfusion compared to control ovaries. Estradiol and progesterone levels did not increase during the perfusion. The perfused ovaries in group 1 and 4 showed a significant decrease in the ovarian reserve and oocyte quality. In total, 16 GV-MI oocytes were retrieved from groups 3 and 4. Limitations, reasons for caution 1. Ovaries were retrieved from ewes of unknown cycle and reproductive history. 2. The perfusion medium was changed after 24 hours from perfusion start to remove detrimental metabolites and this could affect the measured concentrations of hormones and metabolites in the perfusion medium. Wider implications of the findings: These results pave the way to propose ex vivo perfusion as a good platform for fertility preservation studies on whole mammalian and human ovaries to retrieve fully mature oocytes. Trial registration number Not applicable
Information dimension in fractal structures (1989)

We derive an exact formula for the recently introduced information dimension ${D}_{I}$ for random-walk processes in terms of the V(r,n) function, the function that gives the number of sites that have exactly r visits during a random walk on a lattice after n steps. This form is general, and it pertains both to regular lattices and fractal structures. The controlling parameter is ${S}_{n}$, the number of sites visited at least once in an n-step walk. We perform computer simulations on regular lattices and on fractal structures: the Sierpinski gasket, two-dimensional, and three-dimensional percolation clusters exactly at criticality. It is found that ${D}_{I}$ has the same numerical value as the spectral dimension as n\ensuremath{\rightarrow}\ensuremath{\infty}, but it takes unusually long times to reach such behavior.
Bridge to Loop Transition in a Shear Aligned Lamellae Forming Heptablock Copolymer (2004)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTBridge to Loop Transition in a Shear Aligned Lamellae Forming Heptablock CopolymerLifeng Wu, Timothy P. Lodge, and Frank S. BatesView Author Information Department of Chemical Engineering and Materials Science and Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455 Cite this: Macromolecules 2004, 37, 22, 8184–8187Publication Date (Web):October 1, 2004Publication History Received6 July 2004Revised21 September 2004Published online1 October 2004Published inissue 1 November 2004https://pubs.acs.org/doi/10.1021/ma048635whttps://doi.org/10.1021/ma048635wrapid-communicationACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views493Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Conformation,Copolymers,Morphology,Transmission electron microscopy,X-ray scattering Get e-Alerts
Novel Air-gap Formation Technology Using Ru Barrier Metal for Cu Interconnects with High Reliability and Low Capacitance (2011)

A novel technology for obtaining low-capacitance Cu interconnects with air gaps has been proposed. Using a Ru barrier metal as a self-mask, a Cu interconnect was effectively protected from losing its cross-sectional shape during the intermetal dielectric etching process. The wiring capacitance with air-gaps was about 30% lower than that of the conventional low- k ( k = 2.65)/Cu structure without air-gaps. The time-dependent dielectric breakdown (TDDB) lifetime of the air-gap interconnect with a Ru barrier was 100 times longer than that of the low- k /Cu structure. These results indicate that an air-gap interconnect with a Ru barrier metal can be an effective solution to boost the circuit operating speed and to reduce the power dissipation without the degradation of interconnect reliability for devices of 45 nm nodes and beyond.
F-18-ALX5406: Eine hirngängige Prodrug zur PET-Bildgebung des Glycintransporters Typ 1 (2022)

Ziel/Aim ALX5407 ist ein selektiver Inhibitor des Glycintransporters Typ 1 (GlyT1) mit potenziell antipsychotischer Wirkung. Während sein klinischer Nutzen durch dosisabhängige Nebenwirkungen eingeschränkt ist, stellen radiomarkierte Analoga vielversprechende Kandidaten für die Darstellung des GlyT1 mittels PET dar. Ziel dieser Arbeit war, F-18-ALX5407 (F-18-1) sowie den entsprechenden Methylester F-18-ALX5406 (F-18-2) mittels Alkohol-verstärkter, Cu-vermittelter Radiofluorierung darzustellen und biologisch zu evaluieren.
Robust 3.3kV silicon carbide MOSFETs with surge and short circuit capability (2017)

An approach to implement electrically robust MOSFETs in a functioning half-bridge will be investigated. For the first time, reverse conducting 3.3kV SiC MOSFETs have been fabricated with dilferent cell pitches from 14μm (p1.0) to 26μm (pl.8) that are able to withstand short circuit pulse of up to 10μs and a 9ms surge current event up to 15x the nominal current. LinPak half-bridge modules have been fabricated showing reduction of the switching loss by more than 90% compared to a silicon IGBT/diode half bridge.
Evaluation of Water Transport and Oxygen Presence in Single Chamber Microbial Fuel Cells with Carbon-Based Cathodes (2013)

Water transport through the cathode and oxygen presence/absence in the anodic solution, are important for operation and performance of single chamber microbial fuel cells (SCMFCs). This study focused on water transport and biofilm formation on carbon papers with different characteristics: hydrophobicity, thickness, and presence of a micro porous layer (MPL). The results showed that higher hydrophobicity, thicker structures and the presence of the MPL decreased the water transport over time. The carbon papers with low hydrophobicity had complete penetration of biofilms and higher water transport, while those with high hydrophobicity and MPL had no biofilm penetration and lower water transport, indicating a clear correlation of biofilm penetration and water transport across carbon papers. Salt precipitation on carbon papers clogged the pores and resulted in lower water transport. Cyclic voltammograms using Au/Hg microelectrode inserted near the cathode indicated the absence of oxygen in the anodic solution due to the oxygen consumption by aerobic/anaerobic biofilms on cathodes. The results of water transport and oxygen presence illustrated that the biofilms can be used as a cost-effective membrane/separator for SCMFCs.
Measurement of the Higgs boson mass in the H → ZZ⁎ → 4ℓ decay channel using 139 fb−1 of s=13 TeV pp collisions recorded by the ATLAS detector at the LHC (2023)

The mass of the Higgs boson is measured in the H→ZZ⁎→4ℓ decay channel. The analysis uses proton–proton collision data from the Large Hadron Collider at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector between 2015 and 2018, corresponding to an integrated luminosity of 139 fb−1. The measured value of the Higgs boson mass is 124.99±0.18(stat.)±0.04(syst.) GeV. In final states with muons, this measurement benefits from an improved momentum-scale calibration relative to that adopted in previous publications. The measurement also employs an analytic model that takes into account the invariant-mass resolution of the four-lepton system on a per-event basis and the output of a deep neural network discriminating signal from background events. This measurement is combined with the corresponding measurement using 7 and 8 TeV pp collision data, resulting in a Higgs boson mass of 124.94±0.17(stat.)±0.03(syst.) GeV.
Overview of diffraction gratings technologies for space-flight satellites and astronomy (2014)

The diffraction gratings are widely used in Space-flight satellites for spectrograph instruments or in ground-based telescopes in astronomy. The diffraction gratings are one of the key optical components of such systems and have to exhibit very high optical performances. HORIBA Jobin Yvon S.A.S. (part of HORIBA Group) is in the forefront of such gratings development for more than 40 years. During the past decades, HORIBA Jobin Yvon (HJY) has developed a unique expertise in diffraction grating design and manufacturing processes for holographic, ruled or etched gratings. We will present in this paper an overview of diffraction grating technologies especially designed for space and astronomy applications. We will firstly review the heritage of the company in this field with the space qualification of different grating types. Then, we will describe several key grating technologies developed for specific space or astronomy projects: ruled blazed low groove density plane reflection grating, holographic blazed replica plane grating, high-groove density holographic toroidal and spherical grating and transmission Fused Silica Etched (FSE) grismassembled grating.
Practical Synthesis of the New Carbapenem Antibiotic Ertapenem Sodium (2005)

[reaction: see text] A practical synthesis for the large-scale production of the new carbapenem antibiotic, [4R,5S,6S]-3-[[(3S,5S)-5-[[(3-Carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium salt (ertapenem sodium, 1), has been developed. The synthesis features the novel use of 1,1,3,3-tetramethylguanidine as base for the low-temperature reaction of a thiol, derived from trans-4-hydroxy-L-proline, with the carbapenem nucleus activated as the enol phosphate. Hydrogenolysis of a p-nitrobenzyl ester is effected using a palladium on carbon catalyst to give an overall yield for the two steps of 90%. The use of bicarbonate in the hydrogenolysis was key in providing protection of the pyrrolidine amine as the sodium carbamate improving both the performance of the reaction and the stability of the product. This discovery made processing at manufacturing scale possible. Experimental evidence for the formation of the sodium carbamate is provided. A remarkably expedient process for the simultaneous purification and concentration of the aqueous product stream relies on ion-pairing extraction for the removal of the water-soluble 1,1,3,3-tetramethylguanidine. Crystallization then affords 59-64% overall yield of the monosodium salt form of the product.
Functional protein microarrays for parallel characterisation of p53 mutants (2004)

Understanding the way in which single nucleotide polymorphisms and mutations in the human genome result in individual susceptibility to disease is a major goal in the postgenomic era. Such knowledge should accelerate the development of personalised medicine in which drug treatment can specifically match an individual's genotype. High-throughput DNA sequencing is generating the initial information required, but new technologies are required that can rapidly characterise the phenotypic effects of the identified polymorphisms. For example, many thousands of allelic variants of the p53 gene have been described and are responsible for more than 50% of cancers, however few of the protein products have been functionally characterised. Here we have quantified in parallel the effects of mutations and polymorphisms on the DNA-binding function of the p53 oncoprotein using a protein microarray, allowing their subclassification according to functional effect. Protein-protein interactions between p53 variants and (i) a regulatory oncoprotein, (ii) a regulatory kinase resulting in on-chip phosphorylation, are also described, suggesting the more general utility of this high-throughput assay format.
Discovery and Development of a Novel mPGES-1/5-LOX Dual Inhibitor LFA-9 for Prevention and Treatment of Chronic Inflammatory Diseases (2020)

Overall study results suggest that LFA-9 is a mPGES-1/5-LOX dual inhibitor and showed anti-inflammatory and colorectal cancer preventive activities, and warranted detailed studies.
Deinking of Digital Prints: Effect of Near-Neutral Deinking Chemistry on Deinkability (2012)

This article demonstrates the effect of near-neutral deinking chemicals on the outcome of a deinking process. More specifically, we demonstrate that good deinkability of digital prints, i.e.&#xA0;liquid-electrophotographic (LEP), dry-electrophotographic and inkjet (IJ) prints, at the laboratory scale, can be achieved with effective near-neutral deinking chemistry that is based on readily available commercial chemicals. The deinking results meet or exceed the target levels, such as ink speck contamination (i.e.&#xA0;dirt area), ink elimination, filtrate darkening, color shade and luminosity, as defined by the European Recycling Paper Council&#x2019;s deinking scorecard. It is noteworthy that the proposed chemistry has a prominent effect on reducing the dirt area of LEP print media and suppressing the filtrate darkening of dye-based IJ print media. Experimental results using the proposed deinking chemistry compare favorably to those obtained with alkaline deinking chemistry.
An Acoustic Waveguide With Tight Field Confinement for High Temperature Sensing (2020)

A fused quartz acoustic waveguide structure was reported as the suspended core waveguide. The waveguide featured good acoustic wave confinement within the core and a relatively small diameter. Consistent high-temperature sensing was also demonstrated with the waveguide after a temperature sensor was fabricated inside. The waveguide was fabricated by suspending its core rod in the middle of the hollow cladding tube by discrete thin supporting disks. It was found that the characteristics of acoustic propagation in the waveguide was similar to that in a bare core rod and that the waveguide was largely insensitive to lossy surface perturbations. The diameter of the waveguide was relatively small, little more than the bulk longitudinal acoustic wavelength. For sensing, the periodic structure, the acoustic fiber Bragg grating, was fabricated on the core of the suspended core waveguide. A temperature test up to 1000 °C was performed. The central frequency of the reflected acoustic wave was found to change unidirectionally and consistently with changes in temperature. With its good field confinement and consistent sensing capabilities, the suspended core waveguide could find vast potential in many applications.
A Faster Approach to Infrared Rheo-Optics Using a Planar Array Infrared Spectrograph (2004)

Infrared rheo-optics combines dynamic mechanical analysis with infrared spectroscopy to provide molecular level information about the segmental reorientation and the changes in local environment associated with the dynamic deformation of polymers. Up to now, the application of this technique has been limited by the amount of time necessary to perform the experiments. In this article, we demonstrate that the use of a planar array infrared (PA-IR) spectrograph can accelerate the acquisition time by as much as two orders of magnitude while maintaining a signal-to-noise ratio (SNR) similar to that obtained using step-scan Fourier transform infrared (FT-IR) spectrometry, and by more than three orders of magnitude at the expense of a reduced SNR. The advantages and drawbacks of this new technique are discussed.
Intracellular Photoactivation of Caspase-3 by Molecular Glues for Spatiotemporal Apoptosis Induction (2020)

Caspase-3 (Casp-3) is an enzyme that efficiently induces apoptosis, a form of programmed cell death. We report a dendritic molecular glue <sup>PC</sup>Glue that enables intracellular delivery of Casp-3 and its photoactivation. <sup>PC</sup>Glue carrying multiple guanidinium (Gu<sup>+</sup>) ion pendants via photocleavable linkages can tightly adhere to Casp-3 and deliver it into the cytoplasm mainly by direct penetration through the plasma membrane. Casp-3, whose surface is covered by <sup>PC</sup>Glue, is unable to interact with its cellular substrates and can therefore not induce apoptosis. However, upon exposure to UV or two-photon near-infrared (NIR) light, <sup>PC</sup>Glue is cleaved off to liberate Casp-3, triggering the apoptotic signaling cascade. This intracellular photoactivation of Casp-3 allows spatiotemporal induction of apoptosis in irradiated cells.
Preparação e caracterização da zeólita MCM-36 (2003)

MCM-36 zeolite was prepared with initial Si/Al molar ratio of 50. The MCM-22 zeolite with Si/Al ratio of 50 was prepared for comparison. Both zeolites were characterized by several techniques: Chemical Analysis by Atomic Absorption Spectroscopy (AAS), X-Ray Diffraction (XRD), Textural Analysis by N2 and Ar Adsorption, Scanning Electronic Microscopy (SEM) and Infrared Spectrometry (IR). The MCM-36 material is obtained from pillarization of the MCM-22 zeolite precursor material with Si. It was observed that pillarization process provided an increase of basal spacing from 27,5 to > 45 &Aring; and of specific superficial area from 430 to 810m2/g. The MCM-36 material is formed by layers, with a porous system formed by sinusoidal channels of 10MR, separated by pillars that provide a formation of additional mesoporous in a range of 25 &Aring;.
Technical considerations in PCR-based assay design for diagnostic DNA methylation cancer biomarkers (2022)

Large variation in both assay location and design hinders the development of future DNA methylation biomarkers as well as inter-study comparability.
2A1-N-114 Development of a Robotic Forceps System for Laparoscopic Surgery(Medical and Welfare Robotics and Mechatronics 3,Mega-Integration in Robotics and Mechatronics to Assist Our Daily Lives) (2005)

( Measuring force affected on organs to prevent from accident Measuring force affected on forceps
Large time-dependent nonlinear phase shift of transparent conducting oxides at epsilon-near-zero (Conference Presentation) (2020)

Materials with vanishing real part of permittivity, also known as epsilon-near-zero, have emerged as a new paradigm to obtain large optical nonlinearities. In this region, light-matter interaction enhances significantly, which gives rise to an unprecedentedly large nonlinear phase shift. The phase sensitivity enhancement is due to the strong dispersion in this spectral region. We present nonlinear optical measurements via the Beam Deflection technique, to directly measure the spectral dependence of the ultrafast nonlinear phase shift of an Indium Tin Oxide thin film. We present simultaneously cross-phase modulation induced frequency changes that depend on how fast the nonlinear phase changes.
ChemInform Abstract: New Strategy for the Synthesis of the Taxane Diterpenes: Formation of the BC‐Rings of Taxol via a (5 + 2) Pyrylium Ylide‐Alkene Cyclization, Ring Expansion Strategy. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Parametric response mapping as an indicator of bronchiolitis obliterans syndrome in HCT recipients (2014)

The diagnosis of bronchiolitis obliterans syndrome (BOS), an obstructive lung disease that occurs following hematopoietic stem cell transplantation (HCT), is clinically challenging due to the presence of pulmonary infections. We evaluated parametric response mapping (PRM) as an indicator of BOS in HCT patients with acute pulmonary infection. PRM was performed in four subject cohorts: HCT patients diagnosed with acute infection (n=11), BOS (n=34), BOS plus infection (n=9), and age-matched, non-HCT subjects (n=23). The PRM analysis includes a 3D map and joint density histogram of voxels color-coded based on classification: green for normal, yellow for fSAD, red for emphysema and purple for parenchymal disease. Presented in the figure is the PRM analysis of a HCT recipient with BOS that was found to have extensive fSAD (yellow; PRM fSAD =40%). Significantly greater PRM fSAD values were identified in patients with BOS (38±2%) as compared to infection alone (17±4%, p fSAD were observed in patients with BOS, whether a concurrent infection was present or not. PRM is a useful indicator of BOS even in the presence of concurrent pulmonary infection. The PRM biomarker may provide a significant advance in the ability to definitively identify the non-emphysematous small airway obstruction characteristic of BOS.
Natural Human Plasmacytoid Dendritic Cells Induce Antigen-Specific T-Cell Responses in Melanoma Patients (2013)

Vaccination against cancer by using dendritic cells has for more than a decade been based on dendritic cells generated ex vivo from monocytes or CD34(+) progenitors. Here, we report on the first clinical study of therapeutic vaccination against cancer using naturally occurring plasmacytoid dendritic cells (pDC). Fifteen patients with metastatic melanoma received intranodal injections of pDCs activated and loaded with tumor antigen-associated peptides ex vivo. In vivo imaging showed that administered pDCs migrated and distributed over multiple lymph nodes. Several patients mounted antivaccine CD4(+) and CD8(+) T-cell responses. Despite the limited number of administered pDCs, an IFN signature was observed after each vaccination. These results indicate that vaccination with naturally occurring pDC is feasible with minimal toxicity and that in patients with metastatic melanoma, it induces favorable immune responses.