gebhart/patrepeval huggingface dataset:
Low-threshold 1.3-μm wavelength, InGaAsP strained-layer multiple quantum well lasers grown by gas source molecular beam epitaxy (1994)

We report the growth, by gas source molecular beam epitaxy (GSMBE) of low-threshold 1.3-μm wavelength strained-layer In0.86Ga0.14As0.52P0.48/In0.86Ga0.14 As0.3P0.7 separate confinement heterostructure multiple quantum well lasers. Threshold currents as low as 16 mA were measured for a 390×5-μm ridge laser, and a threshold current density of Jth=490 A/cm2 was achieved for a 1200×5-μm device. Apparently, this is the lowest value of Jth reported to date for 1.3-μm lasers grown by GSMBE, and is comparable to the best devices grown by other techniques such as chemical beam epitaxy and metalorganic vapor phase epitaxy.
Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b (2011)

Antigen presentation and microbial killing are critical arms of host defense that depend upon cargo trafficking into lysosomes. Yet, the molecular regulators of traffic into lysosomes are only partly understood. Here, using a lysosome-dependent immunological screen of a trafficking shRNA library, we identified the Arf-like GTPase Arl8b as a critical regulator of cargo delivery to lysosomes. Homotypic fusion and vacuole protein sorting (HOPS) complex members were identified as effectors of Arl8b and were dependent on Arl8b for recruitment to lysosomes, suggesting that Arl8b-HOPS plays a general role in directing traffic to lysosomes. Moreover, the formation of CD1 antigen-presenting complexes in lysosomes, their delivery to the plasma membrane, and phagosome-lysosome fusion were all markedly impaired in Arl8b silenced cells resulting in corresponding defects in T cell activation and microbial killing. Together, these results define Arl8b as a key regulator of lysosomal cellular and immunological functions.
Mechanisms of the Age-Associated Deterioration in Glucose Tolerance (2003)

Glucose tolerance decreases with age. For determining the cause of this decrease, 67 elderly and 21 young (70.1 +/- 0.7 vs. 23.7 +/- 0.8 years) participants ingested a mixed meal and received an intravenous injection of glucose. Fasting glucose and the glycemic response above basal were higher in the elderly than in the young participants after either meal ingestion (P < 0.001) or glucose injection (P < 0.01). Insulin action (Si), measured with the meal and intravenous glucose tolerance test models, was highly correlated (r = 0.72; P < 0.001) and lower (P <or= 0.002) in the elderly than in the young participants. However, when adjusted for differences in percentage body fat and visceral fat, Si no longer differed between groups. When considered in light of the degree of insulin resistance, all indexes of insulin secretion were lower (P < 0.01) in the elderly participants, indicating impaired beta-cell function. Hepatic insulin clearance was increased (P < 0.002), whereas total insulin clearance was decreased (P < 0.002) in the elderly subjects. Multivariate analysis (r = 0.70; P < 0.001) indicated that indexes of insulin action (Si) and secretion (Phi(total)) but not age, peak oxygen uptake, fasting glucose, degree of fatness, or hepatic insulin clearance predicted the postprandial glycemic response. We conclude that the deterioration in glucose tolerance that occurs in healthy elderly subjects is due to a decrease in both insulin secretion and action with the severity of the defect in insulin action being explained by the degree of fatness rather than age per se.
Interactions between Brain Endothelial Cells and Human T-Cell Leukemia Virus Type 1-Infected Lymphocytes: Mechanisms of Viral Entry into the Central Nervous System (2000)

Human T-cell leukemia virus type 1 (HTLV-1) is associated with a variety of clinical manifestations, including tropical spastic paraparesis or HTLV-1-associated myelopathy (TSP/HAM). Viral detection in the central nervous system (CNS) of TSP/HAM patients demonstrates the ability of HTLV-1 to cross the blood-brain barrier (BBB). To investigate viral entry into the CNS, rat brain capillary endothelial cells were exposed to human lymphocytes chronically infected by HTLV-1 (MT2), to lymphocytes isolated from a seropositive patient, or to a control lymphoblastoid cell line (CEM). An enhanced adhesion to and migration through brain endothelial cells in vitro was observed with HTLV-1-infected lymphocytes. HTLV-1-infected lymphocytes also induced a twofold increase in the paracellular permeability of the endothelial monolayer. These effects were associated with an increased production of tumor necrosis factor alpha by HTLV-1-infected lymphocytes in the presence of brain endothelial cells. Ultrastructural analysis showed that contact between endothelial cells and HTLV-1-infected lymphocytes resulted in a massive and rapid budding of virions from lymphocytes, followed by their internalization into vesicles by brain endothelial cells and apparent release onto the basolateral side, suggesting that viral particles may cross the BBB using the transcytotic pathway. Our study also demonstrates that cell-cell fusion occurs between HTLV-1-infected lymphocytes and brain endothelial cells, with the latter being susceptible to transient HTLV-1 infection. These aspects may help us to understand the pathogenic mechanisms associated with neurological diseases induced by HTLV-1 infection.
Syntaxin 1A Supports Voltage-Dependent Inhibition of α1BCa2+Channels by Gβγ in Chick Sensory Neurons (2001)

N-type Ca(2+) channels are modulated by a variety of G-protein-coupled pathways. Some pathways produce a transient, voltage-dependent (VD) inhibition of N channel function and involve direct binding of G-protein subunits; others require the activation of intermediate enzymes and produce a longer-lasting, voltage-independent (VI) form of inhibition. The ratio of VD:VI inhibition differs significantly among cell types, suggesting that the two forms of inhibition play unique physiological roles in the nervous system. In this study, we explored mechanisms capable of altering the balance of VD and VI inhibition in chick dorsal root ganglion neurons. We report that (1) VD:VI inhibition is critically dependent on the Gbetagamma concentration, with VI inhibition dominant at low Gbetagamma concentrations, and (2) syntaxin-1A (but not syntaxin-1B) shifts the ratio in favor of VD inhibition by potentiating the VD effects of Gbetagamma. Variations in expression levels of G-proteins and/or syntaxin provide the means to alter over a wide range both the extent and the rate of Ca(2+) influx through N channels.
Re: Testosterone Replacement Effectively Inhibits the Development of Experimental Autoimmune Orchitis in Rats: Evidence for a Direct Role of Testosterone on Regulatory T Cell Expansion (2011)

No AccessJournal of UrologyInvestigative Urology1 Jan 2012Re: Testosterone Replacement Effectively Inhibits the Development of Experimental Autoimmune Orchitis in Rats: Evidence for a Direct Role of Testosterone on Regulatory T Cell Expansion Anthony AtalaM.D. Anthony AtalaAnthony Atala View All Author Informationhttps://doi.org/10.1016/j.juro.2011.10.007AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Testosterone Replacement Effectively Inhibits the Development of Experimental Autoimmune Orchitis in Rats: Evidence for a Direct Role of Testosterone on Regulatory T Cell Expansion." The Journal of Urology, 187(1), p. 351 © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 1January 2012Page: 351 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Frequency of Uveitis in the Central Tokyo Area (2010–2012) (2016)

When compared with years 2004-2009, the present series showed an increasing trend of intraocular malignant lymphoma, bacterial endophthalmitis, and chronic iridocyclitis, and a notable increase in chronic iridocyclitis in young girls, with decreasing trends of scleritis and Vogt-Koyanagi-Harada disease.
DeLLe (2019)

Geotagged tweet streams contain invaluable information about the real-world local events like sports games, protests and traffic accidents. Timely detecting and extracting such events may have various applications but yet unsolved challenges. In this paper, we present DeLLe, a methodology for automatically Detecting Latest Local Events from geotagged tweets. With the help of novel spatio temporal tweet count prediction models, DeLLe first finds unusual locations which have aggregated unexpected number of tweets in the latest time period and thereby imply potential local events. Next, DeLLe calculates, for each such unusual location, a ranking score to identify the ones most likely having ongoing local events by addressing the temporal burstiness, spatial burstiness and topical coherence. Furthermore, DeLLe infers an event candidate's spatio temporal range by tracking its event-focus point, which essentially reflects the most recent representative occurrence site. Finally, DeLLe chooses the most influential tweets to summarize local events and thereby presents succinct but yet representative descriptions. We evaluate DeLLe on the city of Seattle, WA as well as a larger city of New York. The results show that the proposed method generally outperforms competitive baseline approaches.
Roles of Non-coding RNAs and Angiogenesis in Glioblastoma (2021)

One of the significant hallmarks of cancer is angiogenesis. It has a crucial function in tumor development and metastasis. Thus, angiogenesis has become one of the most exciting targets for drug development in cancer treatment. Here we discuss the regulatory effects on angiogenesis in glioblastoma (GBM) of non-coding RNAs (ncRNAs), including long ncRNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). These ncRNAs may function in <i>trans</i> or <i>cis</i> forms and modify gene transcription by various mechanisms, including epigenetics. NcRNAs may also serve as crucial regulators of angiogenesis-inducing molecules. These molecules include, metalloproteinases, cytokines, several growth factors (platelet-derived growth factor, vascular endothelial growth factor, fibroblast growth factor, hypoxia-inducible factor-1, and epidermal growth factor), phosphoinositide 3-kinase, mitogen-activated protein kinase, and transforming growth factor signaling pathways.
Modified Preview Control for a Wireless Tracking Control System With Packet Loss (2014)

In this paper, a modified preview control technique is proposed to compensate packet loss in a wireless tracking control system, where future reference signals over a finite horizon can be previewed. In order to utilize future reference information for the controller design, the system model is augmented with a reference generator whose states are the future reference signals. As a response to the packet loss that occurs in the wireless network, the preview control technique is modified by employing Bernoulli variables to represent packet loss in both controller-actuator and sensor-controller channels. The Bernoulli packet loss model, along with tracking errors and control inputs, is included in a quadratic cost function, and the optimal controller gain that minimizes the cost function is obtained by dynamic programming. A modified Kalman filter considering packet loss is utilized for full-state estimation and state feedback control. The choice of preview horizon is discussed and the performance of the proposed controller is verified by simulation and experimental results.
Molecular Characterization of an Arabidopsis Gene Encoding Hydroperoxide Lyase, a Cytochrome P-450 That Is Wound Inducible1 (1998)

Hydroperoxide lyase (HPL) cleaves lipid hydroperoxides to produce volatile flavor molecules and also potential signal molecules. We have characterized a gene from Arabidopsis that is homologous to a recently cloned HPL from green pepper (Capsicum annuum). The deduced protein sequence indicates that this gene encodes a cytochrome P-450 with a structure similar to that of allene oxide synthase. The gene was cloned into an expression vector and expressed in Escherichia coli to demonstrate HPL activity. Significant HPL activity was evident when 13S-hydroperoxy-9(Z),11(E),15(Z)-octadecatrienoic acid was used as the substrate, whereas activity with 13S-hydroperoxy-9(Z),11(E)-octadecadienoic acid was approximately 10-fold lower. Analysis of headspace volatiles by gas chromatography-mass spectrometry, after addition of the substrate to E. coli extracts expressing the protein, confirmed enzyme-activity data, since cis-3-hexenal was produced by the enzymatic activity of the encoded protein, whereas hexanal production was limited. Molecular characterization of this gene indicates that it is expressed at high levels in floral tissue and is wound inducible but, unlike allene oxide synthase, it is not induced by treatment with methyl jasmonate.
Predictive business operations management (2006)

The ability to forecast metrics and performance indicators for business operations is crucial to proactively avoid abnormal situations, and to do effective business planning. However, expertise is typically required to drive each step of the prediction process. This is impractical when there are thousands of metrics to monitor. Fortunately, for business operations management, extreme accuracy is not required. It is usually enough to know when a metric is likely to go beyond the normal range of values. This gives opportunity for automation. In this paper, we present an engine that completely automates the prediction of metrics to support a better management of business operations.
Supplementary Figure 9 from TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia (2023)

&lt;p&gt;PDF file - 113K, Bcl2 protein expression in wild-type and Tyk2 knockout mice.&lt;/p&gt;
A Boronic Acid Conjugate of Angiogenin that Shows ROS‐Responsive Neuroprotective Activity (2017)

Angiogenin (ANG) is a human ribonuclease that is compromised in patients with amyotrophic lateral sclerosis (ALS). ANG also promotes neovascularization, and can induce hemorrhage and encourage tumor growth. The causal neurodegeneration of ALS is associated with reactive oxygen species, which are also known to elicit the oxidative cleavage of carbon-boron bonds. We have developed a synthetic boronic acid mask that restrains the ribonucleolytic activity of ANG. The masked ANG does not stimulate endothelial cell proliferation but protects astrocytes from oxidative stress. By differentiating between the two dichotomous biological activities of ANG, this strategy could provide a viable pharmacological approach for the treatment of ALS.
Contribution of Adenosine A2BReceptors in Clostridium difficile Intoxication and Infection (2012)

Clostridium difficile toxins A (TcdA) and B (TcdB) induce a pronounced systemic and intestinal inflammatory response. A(2B) adenosine receptors (A(2B)ARs) are the predominant adenosine receptors in the intestinal epithelium. We investigated whether A(2B)ARs are upregulated in human intestinal cells by TcdA or TcdB and whether blockade of A(2B)ARs can ameliorate C. difficile TcdA-induced enteritis and alter the outcome of C. difficile infection (CDI). Adenosine receptor subtype (A(1), A(2A), A(2B), and A(3)) mRNAs were assayed in HCT-8 cells. Ileal loops from wild-type rabbits and mice and A(2B)AR(-/-) mice were treated with TcdA, with or without the selective A(2B)AR antagonist ATL692 or PSB1115. A murine model of CDI was used to determine the effect of A(2B)AR deletion or blockade with the orally available agent ATL801, on clinical outcome, histopathology and intestinal interleukin-6 (IL-6) expression from infection. TcdA and TcdB upregulated A(2B)AR gene expression in HCT-8 cells. ATL692 decreased TcdA-induced secretion and epithelial injury in rabbit ileum. Deletion of A(2B)ARs reduced secretion and histopathology in TcdA-challenged mouse ileum. Deletion or blockade of A(2B)ARs reduced histopathology, IL-6 expression, weight loss, diarrhea, and mortality in C. difficile-infected mice. A(2B)ARs mediate C. difficile toxin-induced enteritis and disease. Inhibition of A(2B)AR activation may be a potential strategy to limit morbidity and mortality from CDI.
Complexity in the binding of minor groove agents: netropsin has two thermodynamically different DNA binding modes at a single site (2011)

Structural results with minor groove binding agents, such as netropsin, have provided detailed, atomic level views of DNA molecular recognition. Solution studies, however, indicate that there is complexity in the binding of minor groove agents to a single site. Netropsin, for example, has two DNA binding enthalpies in isothermal titration calorimetry (ITC) experiments that indicate the compound simultaneously forms two thermodynamically different complexes at a single AATT site. Two proposals for the origin of this unusual observation have been developed: (i) two different bound species of netropsin at single binding sites and (ii) a netropsin induced DNA hairpin to duplex transition. To develop a better understanding of DNA recognition complexity, the two proposals have been tested with several DNAs and the methods of mass spectrometry (MS), polyacrylamide gel electrophoresis (PAGE) and nuclear magnetic resonance spectroscopy in addition to ITC. All of the methods with all of the DNAs investigated clearly shows that netropsin forms two different complexes at AATT sites, and that the proposal for an induced hairpin to duplex transition in this system is incorrect.
Reaction of the anionic acylmethylidyne cluster [Ru3(CO)9(.mu.3-CO)(.mu.3-CC(O)CH3)]- with carbon monoxide and hydrogen: reversible carbon-carbon and carbon-hydrogen bond forming reactions (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of the anionic acylmethylidyne cluster [Ru3(CO)9(.mu.3-CO)(.mu.3-CC(O)CH3)]- with carbon monoxide and hydrogen: reversible carbon-carbon and carbon-hydrogen bond forming reactionsMichael J. Sailor, Michal Sabat, and Duward F. ShriverCite this: Organometallics 1988, 7, 3, 728–736Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/om00093a025https://doi.org/10.1021/om00093a025research-articleACS PublicationsRequest reuse permissionsArticle Views34Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Akratic robots and the computational logic thereof (2014)

Alas, there are akratic persons. We know this from the human case, and our knowledge is nothing new, since for instance Plato analyzed rather long ago a phenomenon all human persons, at one point or another, experience: (1) Jones knows that he ought not to — say — drink to the point of passing out, (2) earnestly desires that he not imbibe to this point, but (3) nonetheless (in the pleasant, seductive company of his fun and hard-drinking buddies) slips into a series of decisions to have highball upon highball, until collapse. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> Now; could a robot suffer from akrasia? Thankfully, no: only persons can be plagued by this disease (since only persons can have full-blown P-consciousness2, and robots can't be persons (Bringsjord 1992). But could a robot be afflicted by a purely — to follow Pollock (1995) — “intellectual” version of akrasia? Yes, and for robots collaborating with American human soldiers, even this version, in warfare, isn't a savory prospect: A robot that knows it ought not to torture or execute enemy prisoners in order to exact revenge, desires to refrain from firing upon them, but nonetheless slips into a decision to ruthlessly do so — well, this is probably not the kind of robot the U.S. military is keen on deploying. Unfortunately, for reasons explained below, unless the engineering we recommend is supported and deployed, this might well be the kind of robot that our future holds.
Charge Transfer at Hybrid Interfaces: Plasmonics of Aromatic Thiol-Capped Gold Nanoparticles (2015)

Although gold nanoparticles stabilized by organic thiols are the building blocks in a wide range of applications, the role of the ligands on the plasmon resonance of the metal core has been mostly ignored until now. Herein, a methodology based on the combination of spectroscopic ellipsometry and UV-vis spectroscopy is applied to extract dielectric functions of the different components. It is shown that aromatic thiols allow a significant charge transfer at the hybrid interface with the s and d bands of the gold core that yields "giant" red shifts of the plasmon band, up to 40 nm for spherical particles in the size range of 3-5 nm. These results suggest that hybrid nanoplasmonic devices may be designed through the suitable choice of metal core and organic components for optimized charge exchange.
Data Rate Effects on Transition and Remanence Noise in a Modeled Heat-Assisted Magnetic Recording System (2017)

The heat-assisted magnetic recording performance at varying data rate conditions is investigated using an ensemble waveform analysis method. This method decouples the transition signal-to-noise ratio (SNR) and the remanence SNR from the total spatial media SNR. For data rates below 2200 Mbpsi, transition and remanence noises are largely independent of writer field rise time (RT) values less than 150 ps. Above a data rate of 2200 Mbpsi, the transition SNR is significantly degraded for the slowest RTs considered. For all data rate values, the remanence SNR sees minimal degradation with increasing RT. At the highest data rate, at least a 1 dB loss is observed compared with the lowest data rate, across the RT range considered. For comparison, spin-stand data were also collected. The modeled results were contrasted to bit error rate (BER) trends obtained from the measurement. The spin-stand data show a significant BER degradation as a function of increasing RT at higher data rates. This trend is likely explained with the increase in transition noise observed in the model. These results suggest that moderate writer field RTs do not degrade either transition or remanence noise significantly. If RTs can be kept low, higher data rates may be allowable from a media noise perspective.