gebhart/patrepeval huggingface dataset:
Wetting Effects Due to Surfactant Carryover through the Three-Phase Contact Line (2001)

Surfactant transport through the three-phase contact line is studied in relation to the wetting-enhancing effect of surfactants. A specially designed experimental setup is used to simultaneously monitor interfacial adsorption and wetting tension during forced immersion of a hydrophobic or hydrophilic plate into aqueous surfactant solutions. The adsorption at the liquid/solid interface has been measured by ellipsometry, the wetting tension has been determined according to the Wilhelmy plate method, and the adsorption to the liquid/vapor interface has been evaluated from surface tension measurements. The relative importance of different adsorption modes could thereby be grasped. For hydrophobic substrates, the dynamic wetting behavior is strongly affected by surfactant carryover through the advancing three-phase contact line, which appears to be the dominant mode of surfactant transport to the solid/liquid interface. Conversely, for hydrophilic substrates, three-phase contact line carryover of surfactant does not appear to be so important, the predominant transport mode being bulk diffusion.
[Long-Term Survival following Multidisciplinary Therapy for Unresectable Pancreatic Body Cancer]. (2022)

A 57-year-old man was diagnosed with a tumor in the pancreatic body at a nearby hospital and consulted our hospital. Examinations revealed that carbohydrate antigen 19-9(CA19-9)levels were 1,765.0 U/mL. We confirmed metastatic liver tumors in S4 and S8 of the liver by EOB-MRI. We diagnosed unresectable pancreatic cancer(T3N0M1, cStage Ⅳ)and administered 10 courses of gemcitabine(GEM)plus nab-paclitaxel(nab-PTX)therapy. The main lesion and the lesion in S4 subsequently disappeared, and the lesion in S8 degenerated into a cyst. CA19-9 levels were 113 U/mL. Surgery was determined as the best course of action after normalizing CA19-9 levels. Therefore, we further administered 6 courses of FOLFIRINOX therapy and 4 courses of GEM plus nab-PTX therapy, but CA19-9 was not normalized. We decided that it would be difficult to normalize CA19-9, and thus proceeded with surgery. During the operation, cystic degenerative lesions were found in S8 and peritoneal dissemination was found in the transverse mesentery. Because the ascites cytopathology was negative, it was judged that the peritoneal dissemination was localized. We performed distal pancreatectomy(D2)plus partial hepatectomy(S8)plus peritoneal dissemination resection. On day 52 after surgery, we resumed GEM plus nab-PTX. The patient has survived without any recurrence for 3 years after the initial surgery.
<title>Silicon-on-insulator optical rib waveguide circuits for fiber optic sensors</title> (1993)

Optical rib waveguides have been formed in silicon-on-insulator structures. The effects of rib waveguide dimensions on mode and loss characteristics have been studied. Waveguides with dimensions compatible with single mode optical fibers have exhibited single mode behavior with low loss. The compatibility of these silicon-on-insulator waveguide structures with optical fibers, combined with the ability to form active optical modulators in silicon based on free carrier injection/depletion is encouraging for the future use of silicon guided optics in fiber optical and integrated optical sensors. The use of SOI active waveguide circuits for closed loop AC dither fringe detection in interferometric sensors is a possible application area.
Cyclin-Dependent Kinase 5 Phosphorylation of Human Septin SEPT5 (hCDCrel-1) Modulates Exocytosis (2008)

Cyclin-dependent kinase 5 (Cdk5) is predominantly expressed in the nervous system, where it is involved in neuronal migration, synaptic transmission, and survival. The role of Cdk5 in synaptic transmission is mediated by regulating the cellular functions of presynaptic proteins such as synapsin, Munc18, and dynamin 1. Its multifunctional role at the synapse is complex and probably involves other novel substrates. To explore this possibility, we used a yeast two-hybrid screen of a human cDNA library with p35 as bait and isolated human septin 5 (SEPT5), known also as hCDCrel-1, as an interacting clone. Here we report that p35 associates with SEPT5 in GST (glutathione S-transferase)-pull-down and coimmunoprecipitation assays. We confirmed that Cdk5/p35 phosphorylates SEPT5 in vitro and in vivo and identified S327 of SEPT5 as a major phosphorylation site. A serine (S)-to-alanine (A) 327 mutant of SEPT5 bound syntaxin more efficiently than SEPT5 wild type. Additionally, coimmunoprecipitation from synaptic vesicle fractions and Cdk5 wild-type and knock-out lysates showed that phosphorylation of septin 5 by Cdk5/p35 decreases its binding to syntaxin-1. Moreover, mutant nonphosphorylated SEPT5 potentiated regulated exocytosis more than the wild type when each was expressed in PC12 cells. These data suggest that Cdk5 phosphorylation of human septin SEPT5 at S327 plays a role in modulating exocytotic secretion.
Podocyte-Derived BMP7 Is Critical for Nephron Development (2008)

Individuals with congenital renal hypoplasia display a defect in the growth of nephrons during development. Many genes that affect the initial induction of nephrons have been identified, but little is known about the regulation of postinductive stages of kidney development. In the absence of the growth factor bone morphogenic protein 7 (BMP7), kidney development arrests after induction of a small number of nephrons. The role of BMP7 after induction, however, has not been fully investigated. Here, we generated a podocyte-specific conditional knockout of BMP7 (Bmp7(flox/flox);Nphs2-Cre(+) [BMP7 CKO]) to study the role of podocyte-derived BMP7 in nephron maturation. By postnatal day 4, 65% of BMP7 CKO mice had hypoplastic kidneys, but glomeruli demonstrated normal patterns of laminin and collagen IV subunit expression. Developing proximal tubules, however, were reduced in number and demonstrated impaired cellular proliferation. We examined signaling pathways downstream of BMP7; the level of cortical phosphorylated Smad1, 5, and 8 was unchanged in BMP CKO kidneys, but phosphorylated p38 mitogen-activated protein kinase was significantly decreased. In addition, beta-catenin was reduced in BMP7 CKO kidneys, and its localization to intracellular vesicles suggested that it had been targeted for degradation. In summary, these results define a BMP7-mediated regulatory axis between glomeruli and proximal tubules during kidney development.
Mitigation of Sense Amplifier Degradation Using Skewed Design (2020)

Designers typically add design margins to semiconductor memories to compensate for aging. However, the aging impact increases with technology downscaling, leading to the need for higher margins. This results into a negative impact on area, yield, performance, and power consumption. As an alternative, mitigation schemes can be developed to reduce such impact. This paper proposes a mitigation scheme for the memory's sense amplifier (SA); the scheme is based on creating a skew in the relative strengths of the SA's cross-coupled inverters during design. The skew is compensated by aging due to unbalanced workloads. As a result, the impact of aging on the SA is reduced. To validate the mitigation scheme, the degradation of the sense amplifier is analyzed for several workloads. The experimental results show that the proposed mitigation scheme reduces the degradation of the sense amplifier's critical figure-of-merit, the offset voltage, with up to 26%.
ChemInform Abstract: A New Framework for the Cycloaromatization of Enediynes under Mild Conditions. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High-Power Quantum-Dot Superluminescent Diodes With p-Doped Active Region (2006)

We demonstrate the use of p-doping in the active region of quantum-dot superluminescent diodes. Modal gain measurements and light output-current characteristics prove that p-doping is beneficial for achieving higher gain, higher output power, and better temperature stability
Active site studies of neurohypophyseal hormones. Comparison of oxytocin and arginine vasopressin analogs containing 2-D-tyrosine (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTActive site studies of neurohypophyseal hormones. Comparison of oxytocin and arginine vasopressin analogs containing 2-D-tyrosineVictor J. Hruby, Donald A. Upson, Diane M. Yamamoto, Clark W. Smith, and Roderich WalterCite this: J. Am. Chem. Soc. 1979, 101, 10, 2717–2721Publication Date (Print):May 1, 1979Publication History Published online1 May 2002Published inissue 1 May 1979https://pubs.acs.org/doi/10.1021/ja00504a037https://doi.org/10.1021/ja00504a037research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Automated tuning of an eight‐channel cardiac transceive array at 7 tesla using piezoelectric actuators (2014)

Piezoelectric actuators are an attractive means of tuning RF coil arrays to yield more efficient B1 transmission into the subject. An automated mechanism for tuning these elements provides a practical solution for cardiac imaging at UHF, bringing this technology closer to clinical use.
Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors (2020)

Conopeptides are neurotoxic peptides in the venom of marine cone snails and have broad therapeutic potential for managing pain and other conditions. Here, we identified the single-disulfide peptides Czon1107 and Cca1669 from the venoms of <i>Conus zonatus</i> and <i>Conus caracteristicus</i>, respectively. We observed that Czon1107 strongly inhibits the human α3β4 (IC<sub>50</sub> 15.7 ± 3.0 μm) and α7 (IC<sub>50</sub> 77.1 ± 0.05 μm) nicotinic acetylcholine receptor (nAChR) subtypes, but the activity of Cca1669 remains to be identified. Czon1107 acted at a site distinct from the orthosteric receptor site. Solution NMR experiments revealed that Czon1107 exists in equilibrium between conformational states that are the result of a key Ser<sup>4</sup>-Pro<sup>5</sup><i>cis-trans</i> isomerization. Moreover, we found that the X-Pro amide bonds in the inter-cysteine loop are rigidly constrained to <i>cis</i> conformations. Structure-activity experiments of Czon1107 and its variants at positions P5 and P7 revealed that the conformation around the X-Pro bonds (<i>cis-trans</i>) plays an important role in receptor subtype selectivity. The <i>cis</i> conformation at the Cys<sup>6</sup>-Pro<sup>7</sup> peptide bond was essential for α3β4 nAChR subtype allosteric selectivity. In summary, we have identified a unique single-disulfide conopeptide with a noncompetitive, potentially allosteric inhibitory mechanism at the nAChRs. The small size and rigidity of the Czon1107 peptide could provide a scaffold for rational drug design strategies for allosteric nAChR modulation. This new paradigm in the "conotoxinomic" structure-function space provides an impetus to screen venom from other <i>Conus</i> species for similar, short bioactive peptides that allosterically modulate ligand-gated receptor function.
Toward molecular pathogenesis of an autoimmune disease: Refined genetic mapping of autoimmune polyglandular disease type I (APECED) (1994)

Autoimmune reactions encoupled to many human diseases are still only partially understood. Unravelling the molecular pathogenesis of inherited diseases with a strong autoimmune component in their clinical expression could help to dissect individual components in the molecular background of abnormal immune response. One such genetic disorder is autosomal recessive autoimmune polyglandular disease type I (PGD I), also known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, MIM 240300). The disease is especially enriched in the genetically isolated population of Finland and we have assigned the APECED locus to human chromosome 21q22.3 in 14 Finnish families by linkage analyses. The best positional lod score of 6.49 was observed with marker D21S49. Based on the history of the Finns, the gene pool of this population clearly demonstrates the consequences of a founder effect and consequent isolation. In the Finnish population, we can take advantage of linkage disequilibrium and allelic association studies to more precisely define the critical DNA region for our disease gene of interest than would be possible by linkage analyses alone. We are now able to define the chromosomal region of interest between two flanking markers locating 1 cM apart. Linkage disequilibrium is observed with three of the markers used in the analysesmore » and this suggests a distance of less than 500 kb to the disease locus, well approachable with molecular cloning techniques. Overlapping YAC and cosmid clones spanning our region of interest will facilitate the cloning of APECED gene in the near future.« less
Observation of 100 GHz Beat Signal for millimeter-Wave Generation using Mach-Zehnder-Modulator-Based Flat Comb Generator (2009)

We proposed a method for millimeter and terahertz wave generation using a Mach-Zehnder-modulator-based flat comb generator, and showed a 100 GHz beat signal by extracting two modes from 12.5 GHz-spaced comb signals.
In vitro Procoagulant Activity Induced in Endothelial Cells by Chemotherapy and Antiangiogenic Drug Combinations: Modulation by Lower-Dose Chemotherapy (2005)

One of the emerging problems concerning the use of antiangiogenic drugs, when used in combination with certain chemotherapy regimens, is enhanced rates and severity of adverse clotting events. For as yet unknown reasons, certain drugs and particular combinations can induce an elevated incidence of thromboembolic events in treated cancer patients [e.g., SU5416, a vascular endothelial cell growth factor receptor-2 (VEGFR-2) antagonist, when combined with gemcitabine and cisplatin (CDDP)]. Such results highlight the need to develop assays capturing the essence of enhanced clot formation under such combination treatment and which may have predictive potential as well. Here, we report the possibility of such an assay (i.e., the ratio of tissue factor over tissue factor pathway inhibitor expression or activity in cultured human endothelial cells calculated as a coagulation index). A marked increase in coagulation index was observed after exposure to SU5416 and the CDDP/gemcitabine chemotherapy combination in contrast to either of these treatments used alone. Substitution of SU5416 with any one of ZD6474, SU6668, IMC-1121, a monoclonal antibody to VEGFR-2, or an antibody to VEGF (bevacizumab) did not cause a marked increase in the coagulation index, nor did the combination of SU5416 with 5-fluorouracil and leucovorin. Finally, we noted that reducing the concentrations of gemcitabine and CDDP (i.e., use of "metronomic dosing" in vitro) significantly attenuated the coagulation index increase induced by these drugs, suggesting that use of low-dose chemotherapy regimens might be an approach to consider for reducing the incidence of adverse clotting events associated with chemotherapy alone or in conjunction with antiangiogenic drug combination therapies.
A decreased production of IL12 in vitro is associated with isolation of cytopathic HIV-1 strains in HIV-1-infected patients (1998)

The changes in type 1 (IL12, IFN gamma, IL2) and type 2(IL4, IL10) cytokine profiles may be associated with virological parameters of progression of the disease in HIV-1-infected patients. The production of cytokines was studied in LPS + PHA-activated whole-blood culture in HIV-1-infected individuals at different stages of the disease. The association was investigated between IL12p40 and IL12p70 profiles and other cytokines (IFN gamma, IL4, IL10), as well as the isolation of cytopathogenic HIV-1 strains. The phenotype of HIV strains was studied by a micromethod based on P4 cell line, allowing detection of cytopathic effects of HIV-1 isolates (syncytium-induction and cell-killing without syncytium induction). The individual variations in IL12p40 and IL12p70 production were limited in the healthy controls. Low values were observed in HIV-1-infected patients. The production of IL12 (p40 and p70) and the IL12p70/IL4 ratio and the IFN gamma/IL4 ratio were significantly lower in patients with cytopathic isolates compared with patients with noncytopathic isolates, and a correlation was obtained between the values of IL12 (IL12p40 and IL12p70) and those of IFN gamma/IL4 ratio. There was no increase in the secretion of IL4 and IL10 in patients with cytopathic strains compared with other patients. The results indicate a decreased production of type 1 cytokines (IL12, IFN gamma) in the presence of a relatively preserved production of type 2 cytokines (IL4, IL10) in HIV-1-infected patients. In conclusion, the defect of production of IL12 by whole blood is associated with virological correlates of progression of HIV-1 disease.
ChemInform Abstract: Parallel Synthesis with Fluorous Reagents and Reactants (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The structural modification of the vapor-grown carbon whisker for a high performance anode of lithium rechargeable batteries (1994)

The well-graphitized vapor-grown carbon whisker that was prepared by the modified procedure showed a high capacity (362 mAh/g) in 1 mol/dm{sup 3}-LiClO{sub 4}/ethylene carbonate (EC) + diethylcarbonate (DEC) electrolyte. Two procedures were examined to prepare the carbon whiskers: in the normal procedure (1A), the whiskers were graphitized after the chopping process, and in the other procedure (2A), they were chopped after the graphitization. The carbon whiskers by the 2A method showed much higher capacity than the whiskers of the same diameter by the 1A. In particular, 2GWH-2A showed the capacity of 362 mAh/g that is 1.6 times of that of 2GWH-1A. The cyclic voltammogram of 2GWH-2A was most different from that of natural graphite among all of the whiskers. The Raman spectrum of 2GWH-2A is suggested that a new structure affecting on the lithium-storage reaction is introduced to the well-graphitized whisker during the chopping process.
A Novel Gastric Ulcer Differentiation System Using Convolutional Neural Networks (2018)

Gastric cancer can present itself as a gastric ulcer, which can mimic a benign gastric ulcer. In this paper, we introduce an objective and precise gastric ulcer differentiation system based on deep convolutional neural network (CNN) which can support the specialists by improving the diagnostic accuracy of the endoscopic examination of gastric ulcers. We first generated a new dataset consisting of endoscopic images of gastric ulcers and their corresponding type labels obtained by biopsy. We then design various ulcer differentiation models using classification or detection networks, and evaluate the performance of the models on the new dataset. Experimental results confirm that the classification network-based method shows performance comparable to doctors' diagnosis, and the detection network-based one, which first detects ulcer regions and then determines the type of ulcer based on the detection results, exhibits the best performance. The proposed method provides an unbiased diagnosis and it outperforms endoscopic diagnoses performed by the specialists in terms of total accuracy.
Novel synthetic retinoic acid inhibits rat collagen arthritis and differentially affects serum immunoglobulin subclass levels (1996)

Retinoids affect many biological processes such as cell proliferation, differentiation and morphogenesis, but their effects on arthritic patients and animal models of arthritis are controversial. We tested the effect of a novel synthetic retinoic acid, Am-80 (4-[(5,6,7,8-tetrahydro-5,5,8,8,-tetramethyl-2-naphthalenyl) carbamoyl] benzoic acid), on type-II collagen (CII)-induced arthritis (CIA) in rats. Am-80 markedly suppressed the incidence of arthritis, hindpaw swelling and bone destruction. In contrast, 13-cis-retinoic acid (13-cis-RA) hardly inhibited these CIA symptoms. Moreover, Am-80, but not 13-cis-RA, strongly reduced the serum level of anti-CII antibody and differentially affected the levels of immunoglobulin (Ig) subclasses in vivo: IgG1 and IgG2a levels were decreased, while IgA level was increased without any change in the IgM level. These findings indicate that Am-80 may be one of the lead retinoic acids of a new class of anti-inflammatory agents.
Manipulating Triplet Yield through Control of Symmetry-Breaking Charge Transfer (2018)

The efficiency of an organic solar cell depends on the efficacy of exciton diffusion and dissociation processes, and this can be enhanced by reducing the exciton binding energy and increasing the exciton lifetime. Zinc chlorodipyrrin (ZCl) complexes exhibit reduced exciton binding energy due to ultrafast generation of intramolecular charge transfer (ICT) states via symmetry-breaking charge transfer in polar media. This Letter explores the fate of the ICT states using nanosecond transient absorption. In cyclohexane, ZCl undergoes intersystem crossing to produce triplets with ∼8 ns time constant (∼30% yield), and no ICT states are generated. However, in more polar solvents, triplets are generated within 1 ns via ICT state recombination with ∼3 times higher yield than produced via ISC. This high triplet yield in toluene (89%) and acetonitrile (76%) via ICT state recombination is a beneficial pathway to spin-protect the excited-state decay for additional charge generation from triplet excited states.
A Hydrodynamic Efficiency Parameter as a Novel Left Ventricular Diastolic Dysfunction Diagnostic Metric (2008)

Numerous studies have shown that cardiac diastolic dysfunction and diastolic filling play a critical role in dictating overall cardiac health and demonstrated that the filling wave propagation speed is a significant index of the severity of diastolic dysfunction [1, 2]. However, the governing flow physics underlying the relationship between propagation speed and diastolic dysfunction are poorly understood. More importantly, currently there is no reliable metric to allow clinicians the ability to diagnose cardiac dysfunction on the basis of the wave filling speed.