gebhart/patrepeval huggingface dataset:
Homogeneous Emission Line Broadening in the Organo Lead Halide Perovskite CH3NH3PbI3–xClx (2014)

The organic–inorganic hybrid perovskites methylammonium lead iodide (CH3NH3PbI3) and the partially chlorine-substituted mixed halide CH3NH3PbI3–xClx emit strong and broad photoluminescence (PL) around their band gap energy of ∼1.6 eV. However, the nature of the radiative decay channels behind the observed emission and, in particular, the spectral broadening mechanisms are still unclear. Here we investigate these processes for high-quality vapor-deposited films of CH3NH3PbI3–xClx using time- and excitation-energy dependent photoluminescence spectroscopy. We show that the PL spectrum is homogenously broadened with a line width of 103 meV most likely as a consequence of phonon coupling effects. Further analysis reveals that defects or trap states play a minor role in radiative decay channels. In terms of possible lasing applications, the emission spectrum of the perovskite is sufficiently broad to have potential for amplification of light pulses below 100 fs pulse duration.
alpha1 AR-MEDIATED CONTRACTION IN HUMAN MAMMARY ARTERY IS MEDIATED BY alpha1a and alpha1b AR SUBTYPES (1999)

Introduction: alpha1-adrenergic receptors (alpha1a, alpha1b, alpha1d ARs) regulate blood pressure, as well as regional vascular resistance and venous capacitance. We recently demonstrated that both alpha1a and alpha (1b) ARs are present in human mammary artery [1]. However, the presence of a protein does not guarantee functional responsiveness. Therefore we tested the hypothesis that both alpha1 AR subtypes are functionally active in human mammary artery. Methods: With IRB approval, human mammary artery was obtained from patients during CABG surgery. Each vessel was cleaned, hung, and tested with KCl, then examined for the effect of various alpha1 AR antagonists (prazosin, non-subtype selective; 5-MU, alpha1a selective; spiperone, alpha1b selective; BMY7378, alpha1d selective) on phenylephrine (Phe)-induced mammary artery contraction assays. Results: Antagonists prazosin, 5-MU, and spiperone demonstrate a concentration dependent shift in potency of Phe contraction curves without reducing maximum response. BMY7378 does not produce a significant shift. Figure 1Figure 1Discussion: Both alpha1a and alpha1b AR subtypes are functionally responsive in human mammary artery. These findings are in contrast to previously reported studies in rat vasculature, suggesting predominance of alpha1a (mesenteric) and alpha1d (aorta) [2,3], and therefore provide potentially novel targets for intervention in mammary arteries used in coronary revascularization.
A Minimal Coherent Receiver for 200 Gb/s/λ PON Downstream With Measured 29 dB Power Budget (2023)

We experimentally demonstrate 200 Gb/s/ <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\lambda $ </tex-math></inline-formula> downstream transmission for a passive optical network (PON) with a minimal coherent receiver at optical network unit (ONU). The low complexity receiver required at the cost-sensitive ONU employs heterodyne detection and requires a single photodiode, a 3-dB optical coupler and a local oscillator, and is the simplest coherent receiver. At the optical line terminal (OLT), digital pre-emphasis and Alamouti-coding is applied to the 50 GBaud signal. A power budget of 29 dB is experimentally demonstrated, increasing to 34.5 dB if a balanced receiver is utilized.
Proteinase expression during differentiation of human osteoclasts in vitro (2000)

Osteoclasts are macrophage-derived polykaryons that degrade bone in an acidic extracellular space. This differentiation includes expression of proteinases and acid transport proteins, cell fusion, and bone attachment, but the sequence of events is unclear. We studied two proteins expressed at high levels only in the osteoclast, cathepsin K, a thiol proteinase, and tartrate-resistant acid phosphatase (TRAP), and compared this expression with acid transport and bone degradation. Osteoclastic differentiation was studied using human apheresis macrophages cocultured with MG63 osteosarcoma cells, which produce cytokines including RANKL and CSF-1 that mediate efficient osteoclast formation. Immunoreactive cathepsin K appeared at 3-5 days. Cathepsin K activity was seen on bone substrate but not within cells, and cathepsin K increased severalfold during further differentiation and multinucleation from 7 to 14 days. TRAP also appeared at 3-5 d, independently of cell fusion or bone attachment, and TRAP activity reached much higher levels in osteoclasts attached to bone fragments. Two proteinases that occur in the precursor macrophages, cathepsin B, a thiol proteinase related to cathepsin K, and an unrelated lysosomal aspartate proteinase, cathepsin D, were also studied to determine the specificity of the differentiation events. Cathepsin B occurred at all times, but increased two- to threefold in parallel with cathepsin K. Cathepsin D activity did not change with differentiation, and secreted activity was not significant. In situ acid transport measurements showed increased acid accumulation after 7 days either in cells on osteosarcoma matrix or attached to bone, but bone pit activity and maximal acid uptake required 10-14 days. We conclude that TRAP and thiol proteinase expression begin at essentially the same time, and precede cell fusion and bone attachment. However, major increases in acid secretion and proteinases expression continue during cell fusion and bone attachment from 7 to 14 days.
A personal perspective on visualization and visual analytics (2014)

Data surrounds each and every one of us in our daily lives, ranging from logs of exercise and diet, to information about our home energy use, to archives of our interactions with others on social media, to online resources pertaining to our hobbies and interests. There is enormous potential for us use this data to gain insight and knowledge about ourselves and our communities. However, designing and applying visualization and visual analytics in our personal lives brings a unique set of design challenges. If these tools belong in our personal lives, work type criteria such as efficiency may no longer apply. In this workshop we will identify and explore research directions and design criteria for personal visualization and personal visual analytics. Our goal is to call research attention to these areas, to engage the design community in this timely and growing field, and to establish a community and common vision for researchers and practitioners working in this space.
Synthesis of Branched Polyethylene by Tandem Catalysis (2001)

Linear low-density polyethylene (LLDPE) can be prepared by addition of ethylene to a mixture of two catalysts. In this “tandem catalysis” scheme one catalyst dimerizes or oligomerizes ethylene to α-olefins while the second site incorporates these α-olefins into a growing polyethylene chain. A variety of classical catalyst combinations are available for this purpose. Better control over the polymerization process, and therefore product properties, is attained by the use of homogenous “single site” catalysts. The best-behaved tandem processes take advantage of well-defined catalysts that require stoichiometric quantities of activators. One such system employs [(C6H5)2PC6H4C(OB(C6F5)3)O-κ2P,O]Ni(η3-CH2CMeCH2) and {[(η5-C5Me4)SiMe2(η1-NCMe3)]TiMe}{MeB(C6F5)3}. The nickel sites are responsible for converting ethylene to 1-butene or mixtures of 1-butene with 1-hexene. These olefins are copolymerized with ethylene at the titanium sites. It is possible to obtain a linear correlation between the branching content in the polymer product and the Ni/Ti ratio. The effect of ligand substitution at nickel has also been investigated. When the benzyl derivative [(C6H5)2PC6H4C(O-B(C6F5)3)O-κ2P,O]Ni(η3-CH2C6H5) is used instead of the methallyl counterpart [(C6H5)2PC6H4C(OB(C6F5)3)O-κ2P,O]Ni(η3-CH2CMeCH2), one obtains, at a constant Ni/Ti ratio, considerably more branching in the final polymer structure. These results are rationalized in terms of a more efficient initiation when the more labile benzyl ligand is used.
LEGO Materials (2008)

Two papers in this issue report important developments in the field of inorganic nanomaterials. Chen and O'Brien discuss self-assembly of semiconductor nanocrystals into binary nanoparticle superlattices (BNSLs). They show that simple geometrical principles based on maximizing the packing density can determine BNSL symmetry in the absence of cohesive electrostatic interactions. This finding highlights the role of entropy as the driving force for ordering nanoparticles. The other paper, by Weller and co-workers, addresses an important problem related to device integration of nanoparticle assemblies. They employ the Langmuir-Blodgett technique to prepare long-range ordered monolayers of close-packed nanocrystals and transfer them to different substrates.
Characterization of Interconnect Defects Using Scanning Thermal Conductivity Microscopy (2004)

Abstract In this paper, scanning thermal conductivity microscopy is used to characterize interconnect defects due to electromigration. Similar features are observed both in the temperature and thermal conductivity micrographs. The key advantage of the thermal conductivity mode is that specimen bias is not required. This is an important advantage for the characterization of defects in large scale integrated circuits. The thermal conductivity micrographs of extrusion, exposed and subsurface voids are presented and compared with the corresponding topography and temperature micrographs.
Role of Class 1 Serine Protease Autotransporter in the Pathogenesis of Citrobacter rodentium Colitis (2014)

A growing family of virulence factors called serine protease autotransporters of Enterobacteriaceae (SPATEs) are secreted by Shigella, Salmonella, and Escherichia coli pathotypes. SPATEs are subdivided into class 1 and class 2 based on structural features and phylogenetics. Class 1 SPATEs induce cytopathic effects in numerous epithelial cell lines, and several have been shown to cleave the cytoskeletal protein spectrin in vitro. However, to date the in vivo role of class 1 SPATEs in enteric pathogenesis is unknown. Citrobacter rodentium, a natural mouse pathogen, has recently been shown to harbor class 1 and class 2 SPATEs. To better understand the contribution of class 1 SPATEs in enteric infection, we constructed a class 1 SPATE null mutant (Δcrc1) in C. rodentium. Upon infection of C57BL/6 mice, the Δcrc1 mutant exhibited a hypervirulent, hyperinflammatory phenotype compared with its parent, accompanied by greater weight loss and a trend toward increased mortality in young mice; the effect was reversed when the crc1 gene was restored. Using flow cytometry, we observed increased infiltration of T cells, B cells, and neutrophils into the lamina propria of the distal colon in mice fed the Δcrc1 mutant, starting as early as 5 days after infection. No significant difference in epithelial cytotoxicity was observed. Reverse transcription-PCR (RT-PCR) analysis of distal colonic tissue on day 10 postinfection showed significant increases in mRNA encoding cytokines interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), gamma interferon (IFN-γ), IL-1β, and inducible nitric oxide synthase (iNOS) but not in mRNA encoding IL-17, IL-4, or IL-10 in the Δcrc1 mutant-infected mice. Our data suggest a previously unsuspected role for class 1 SPATEs in enteric infection.
Diffusion profiling using the graded C(V) method (1980)

A simple and quick technique for determination of impurity-diffusion profiles in semiconductors from MOS <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C(V)</tex> measurements on a gradually etched surface is presented and analyzed, This technique is most useful for slowly varying profiles in the range of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">16</sup> -5 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">18</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> . Experimental profiles are given for P in Si, and for Cd in InSb.
Intraoperative functional brain imaging - hemodynamic response visualization using Laser Doppler (2008)

Optics -Laser Doppler Imaging
Program Execution on Multicore and Heterogenous Systems (2010)

As uniprocessor performance fails to improve at the&#13;\nerstwhile rates, computer architects are turning to&#13;\nmulticore architectures to stay on the performance&#13;\ncurve. Parallel programming holds the key to&#13;\nunlocking the performance benefits of such architectures.&#13;\nConventional parallel programming models require&#13;\nprogrammers to abandon the well established sequential&#13;\nprogramming paradigm, and write parallel programs.&#13;\nSuch models are fraught with pitfalls such as deadlocks,&#13;\nlivelocks, nondeterminism, etc. Recently Allen et.&#13;\nal. [3] introduced a new dynamic dependence based&#13;\nprogramming model, called Serialization Sets, which&#13;\nmaintains the sequential program semantics and yet&#13;\ndelivers performance comparable to the conventional&#13;\nmethods. While we extended the Serialization Sets&#13;\nmodel in [21], to allow programmers to express&#13;\ndata dependencies between computations, and extracted&#13;\nadditional parallelism, the model still had limited&#13;\ncapability to discover parallelism. In this work, we&#13;\npropose a generic dataflow execution model capable&#13;\nof exploiting all possible parallelism, using the same&#13;\nimperative programming framework. We present the&#13;\ndetails of the implementation and show that the new&#13;\nmodel improves the performance of the applications we&#13;\ndeveloped by 15%-25% on a general purpose multicore&#13;\narchitecture, and at the same time scales well with the&#13;\nincrease in the number of processors. We also apply&#13;\nthis framework to another class of architecture, GPGPU,&#13;\nand show we are able to derive similar performance&#13;\nbenefits while greatly simplifying programming for such&#13;\narchitectures.
Resonant Converter Design Using Two-Port Passive Network: Single Frequency Design (2018)

This paper proposes a design method of resonant converter through two-port network analysis. The impedance conversion characteristics of a two-port network consisting solely of passive elements are analyzed at a single frequency. Through this analysis, this paper presents a general method of designing resonant networks that satisfy the desired input- and output-specifications under the rated conditions and has the desired characteristics for load variations. This design method allows designers to configure resonant networks suitable for specific applications without relying on case studies. To verify the proposed design concept, design examples are introduced and simulation results are provided.
ChemInform Abstract: SYNTHESIS OF α‐METHYLENE‐Γ‐LACTONES INVOLVING BAEYER‐VILLIGER OXIDATION OF α‐SUBSTITUTED CYCLOBUTANONES (1976)

Abstract Baeyer‐Villiger‐Oxidation bicyclischer Ketone wird nach Methode A) mit m‐Chlorperbenzoesäure in CHCla in Gegenwart von NaHCO 3 und nach Methode B) mit H 2 O 2 /Essigsäure in Na‐acetat durchgeführt.
Recent advances in multidimensional sensor array signal processing (1989)

Summary form only given. ESPRIT is a patented technique for high-resolution estimation of signal parameters that exploits an invariance structure designed into the sensor array to achieve a reduction in computational requirements of many orders of magnitude over previous techniques such as MUSIC, Burg's MEM, and Capon's ML, with virtually no loss in performance as measured by parameter estimate variance. Whereas ESPRIT only requires that the sensor array possess a single invariance best visualized by considering tow identical but otherwise arbitrary arrays of sensors displaced (but not rotated) with respect to each other, many arrays currently in use in various applications are uniform arrays of identical sensor elements with displacements in more than one dimension. The uniformly sampled phased-array radar is a typical example, and such systems are commonplace in high-resolution direction finding systems. Such arrays possess many invariances in potentially more than one dimension. Recent developments in extending the concepts behind ESPRIT to multiple invariances and multidimensional parameter spaces were examined.
T49. SOCIODEMOGRAPHIC AND LIFESTYLE FACTORS ASSOCIATED WITH GOOD PERFORMANCE IN PAIRED ASSOCIATES LEARNING TEST IN PATIENTS WITH SCHIZOPHRENIA (2020)

Abstract Background Schizophrenia patients have been found to have long lasting, clinical state independent impairments in intellectual abilities as well as in specific cognitive domains of which visual learning and memory are central to our current study. The main aim of this study was to investigate the sociodemographic and lifestyle factors associated with good visual learning and memory in patients with schizophrenia in a sample of patients. Methods The basic population for this study consists of Finnish SUPER study on genetic mechanisms of psychotic disorders (SUPER), part of the Stanley Global Neuropsychiatric Genomics Initiative. The Northern Finland Birth Cohort 1966 (NFBC 1966) functioned as a reference group to define good cognitive performance. The Finnish SUPER study on genetic mechanisms of psychotic disorders is a part of the international Stanley Global Neuropsychiatric Genomics Initiative. The objective of the study is to understand the genetic and biological background of psychotic disorders. The participants of the present study were patients with clinical diagnosis of schizophrenia who were born between 1950–1979 (N=1,907). The reference group of members of the NFBC 1966 consisted 5,506 individuals aged 46–47 years. Paired Associates Learning (PAL) was used both in SUPER and NFBC 1966 studies. PAL test measures visual memory and new learning. We used the primary outcome variable of ‘total errors adjusted’ (TEA) which assesses learning over repeated attempts. Lower than the mean score of TEA of NFBC 1966 was used as cut-off for good performance in PAL test. SUPER participants with good performance in the PAL test were compared to other SUPER participants. Participants in SUPER study were interviewed and filled in a questionnaire about general mental wellbeing, subjective health and lifestyle factor. The association of following sociodemographic and lifestyle factors were investigated: education, age, marital status, self-rated memory, psychotropic medication use, alcohol consumption and cigarette smoking. Results Of the SUPER participants, 129 (6,9 %) performed at least on the level on which 50% of the participants of the NFBC 1966 performed. Of SUPER participant males 5,9 % and of the females 8,1 % performed on this level. Performing above the NFBC 1966 50% level in the PAL test was associated with higher educational level and higher use of alcohol in males, and with higher educational level and being married in females. Discussion In previous studies age, education, duration of illness, severity of symptoms have been found to count for some of the overall impairments found in schizophrenia. We found a subgroup of schizophrenia patients with good visual learning and memory and sociodemographic and lifestyle factors that were associated with good performance. In our study education and marital status in women and alcohol use in men was associated with better performance in PAL test.
Experimental study of granular convection (1996)

Dry granular material confined to a cylindrical vessel convects when subjected to either continuous or discrete vertical oscillations of sufficient intensity. Particles flow upward in the center of the container and fall in a thin stream along the wall. We have studied this motion experimentally in three-dimensional cylinders for a variety of material, container, and vibration parameters using tracer particle techniques and magnetic resonance imaging. By combining these methods, we have characterized both the depth and radial dependence of the vertical flow velocity. We find that the upward flow velocity along the cylinder axis decays exponentially from the top free surface into the bulk of the material. This flow decreases and changes direction as the inner container walls are approached, displaying a radial dependence closely approximated by either a hyperbolic cosine or a modified Bessel function of order zero. We propose a simple model of granular convection consistent with these findings. \textcopyright{} 1996 The American Physical Society.
Epigenetic maintenance of stemness and malignancy in peripheral neuroectodermal tumors by EZH2 (2009)

Chromatin modifications are increasingly recognized as a key mechanism in cancer. The histone methyltransferase Enhancer of Zeste, Drosophila, Homolog 2 (EZH2), the enzymatic subunit of the polycomb PRC2 complex methylates histone H3K27, thereby, mediating gene silencing. EZH2 is overexpressed in a variety of tumor tissue including breast and prostate. Ewing tumors (ET), alias peripheral neuroectodermal tumors (PNET), are highly malignant tumors molecularly defined by ews/ets translocations. We found EWS-FLI1 bound to the EZH2 promoter in vivo. Other components of the PRC2 complex, like EED or SUZ12 were not deregulated in ET. Downregulation of EZH2 by RNA interference suppressed tumor development and metastasis in vivo and microarray analysis of EZH2 knock down revealed an EZH2-maintained, undifferentiated, reversible phenotype in ET. EZH2 suppression resulted in a generalized loss of H3K27me3 as well as increase in H3 acetylation. ChIP-Chip assays for H3K27me3 verified such genes that had specifically lost H3K27me3 upon EZH2 silencing, suggesting that stemness features are preserved via epigenetic mechanisms. Taken together, the genetic EWS-FLI1 translocation is intimately linked to global and gene specific epigenetic alterations in ET biology. EZH2 mediates neuroectodermal and endothelial embryonal tumor stem cell growth and metastatic spread induced by a translocation derived chimeric transcription factor.
Plastic Part Design (2022)

No AccessInjection Mold Design EngineeringOct 2022Plastic Part DesignDavid O. KazmerDavid O. Kazmerhttps://doi.org/10.3139/9781569908921.002SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF ShareFacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2022Pages: 23-59Print ISBN: 978-1-56990-891-4eISBN: 978-1-56990-892-1 Copyright & Permissions© 2022 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in breast cancer cell lines. (2003)

The fragile histidine triad (FHIT) gene at chromosome 3p14.2 is a tumor suppressor gene that is altered mainly by deletion in a large fraction of human tumors, including breast cancers. To evaluate the potential of FHIT gene therapy in this type of cancer, we have studied the biological effects of adenoviral FHIT transduction (Ad-FHIT) in breast cancer cell lines. The results showed that, after FHIT restoration in BT-549, MDA-MB-436, and HCC1806 cells, they underwent apoptosis by activation of the intrinsic pathway. In all three cell lines infected with Ad-FHIT, we have found activation of caspase-2, which is required for permeabilization of mitochondria, release of cytochrome c, and apoptosis. Furthermore, Fhit overexpression produces alteration in cell cycling properties, as well as reduction of the tumorigenic potential in nude mice.