gebhart/patrepeval huggingface dataset:
Eye Height/Width Prediction From <inline-formula> <tex-math notation="LaTeX">$S$ </tex-math> </inline-formula>-Parameters Using Learning-Based Models (2016)

Design space exploration and sensitivity analysis for electrical performance of high-speed serial links is a critical and challenging task for a robust, cost-efficient, and signal-integrity-compliant channel design. The generation of time-domain (TD) metrics like eye height and eye width at higher bit error rates requires longer bit sequences in TD circuit simulation, which is compute time intensive. Intelligent techniques to identify smaller design sets that cover the design space optimally may provide incorrect sensitivity analysis. This paper explores learning-based modeling techniques that rapidly map relevant frequency-domain metrics like differential insertion loss and total cross talk, in the presence of equalization, to TD metrics like eye height and eye width, thus facilitating a full-factorial design space sweep. Numerical results performed with multilayer-perceptron-based artificial neural network as well as least-squares support vector machine (LS-SVM) on Serial ATA 3.0 and Peripheral Component Interconnect Express Gen3 channels generate an average error of less than 2%.
Anticoagulant Effects of Synthetic Retinoids Mediated Via Different Receptors on Human Leukemia and Umbilical Vein Endothelial Cells (1997)

We recently found that retinoic acids (RAs) exert anticoagulant effects by upregulating thrombomodulin (TM) and downregulating tissue factor (TF) expression in acute promyelocytic leukemia (APL) cells and monoblastic leukemia cells. Two classes of nuclear RA receptors, termed retinoic acid receptors (RARs) and retinoid X receptors, have been identified. Each receptor class consists of three subtypes. In the present study, we have used several synthetic retinoids to determine which receptor subtypes are involved in the regulation of TM and TF expression in NB4 APL cells, U937 monoblastic leukemia cells, and human umbilical vein endothelial cells (HUVECs). Am80, which has no binding affinity for RAR gamma, and Ch55, which does not bind to cytoplasmic retinoic acid binding protein (CRABP), upregulated TM and downregulated TF in NB4 and U937 cells, similar to all-trans RA (ATRA). A specific RAR alpha antagonist, Ro41-5253, significantly suppressed the upregulation of TM by ATRA and Am80 in NB4 cells, U937 cells, and HUVECs. In contrast, only with preincubation with both RAR alpha and RAR beta antagonists was downregulation of TF by retinoids suppressed in NB4 cells. These findings indicate that the mechanism of transactivation and transrepression functions of RARs are distinct and also elucidate the major role of RAR alpha in TM upregulation by retinoids in leukemic cells and HUVECs and the cooperation of RAR alpha and RAR beta in TF downregulation by retinoids. They also indicate that binding to CRABP is not required for the anticoagulant effect of retinoids and that synthetic retinoids will prove very useful in controlling distinct targets, the TM and TF genes, at the level of transcription, and will permit the development of retinoids with a new type of anticoagulant effect.
Testing Speech Perception with Cochlear Implants Through Digital Audio Streaming in a Virtual Sound Booth: A Feasibility Study (2021)

By pre-processing the test materials to emulate the noise and reverberation characteristics of a traditional SB, we can account for differences in speech-perception scores between those obtained via DAS and in a SB.
Scavenger Receptor Class B Type I–Mediated Protection Against Atherosclerosis in LDL Receptor–Negative Mice Involves Its Expression in Bone Marrow–Derived Cells (2003)

SR-BI expression protects against atherosclerosis in LDL receptor-deficient as well as apolipoprotein E-deficient mice, and its expression in bone marrow-derived cells contributes to this protection.
A status report on the OO7 OODBMS benchmarking effort (1994)

The OO7 Benchmark was first published in 1993, and has since found a home in the marketing literature of various object-oriented database management system (OODBMS) vendors. The OO7 Benchmark (as published) was the initial result of an ongoing OODBMS performance evaluation effort at the University of Wisconsin. This paper provides an update on the status of the effort on two fronts: single-user and multi-user. On the single-user front, we review and critique the design of the initial OO7 Benchmark. We discuss some of its faults, the reasons for those faults, and things that might be done to correct them. On the multi-user front, we describe our current work on the development of a multi-user benchmark for OODBMSs. This effort includes changes and extensions to the OO7 database and the design of a family of interesting multi-user workloads.
ChemInform Abstract: METATHESIS OF ACETYLENES BY TRIPHENOXYTUNSTENACYCLOBUTADIENE COMPLEXES AND THE CRYSTAL STRUCTURE OF W(C3ET3)(O‐2,6‐C6H3(I‐PR)2)3 (1985)

Abstract Durch Behandeln des Carbinkomplexes (I) mit dem Li‐alkoxid (II) wird der Komplex (III) erhalten, der bei Reaktion mit 2 Äquiv.
REACTIVITY OF THE METAL-METAL MULTIPLE BOND IN METAL CARBONYL DERIVATIVES X *. REINVESTIGATION OF THE REACTION OF ( $-C, Me, (CO), Mot 2- (Mo=Mo) WITH PHOSPHORUS LIGANDS: FORMATION OF (C,Mq),Mo,(CO),PR,-(Mo340) (PR, = P(OMe),; PhP(OCH2CH,),NH) AND C,Me,(CO),(P(OMe),)Me, AND THE CRYSTAL STRUCTURE OF (C,Me5)2M02(CO)31P~(OCH2CH2)2NHI (1985)

In spite of the increase in steric crowding, [C,Me,(CO),Mo], (II), was found to I / react with P(OMe), or with the bicyclic aminophosphorane PhP(H)(OCH$H,),N in boiling toluene to give the CO-replacement products (C,Me,),Mo,(CO),P(OMe), (V) and (C,Me,),Mo,(CO),(phoran) (VI), respectively, in which “phoran” represents the open tautomeric form of the phosphorane. As a further product of the P(OMe), reaction, C,Me,(CO),M4P(OMe),]CH, (VII) was isolated in yields varying with the reaction conditions. The two dinuclear compounds are the first examples of pentamethylcyclopentadienyl molybdenum dimers containing phosphorus ligands, as well as the first dissymmetrically substituted derivatives of II. Their isolation is in contrast with the previously reported inertness of II towards phosphorus ligands, and extends the range of its reactions in which MeMo is preserved. The crystal structure of VI is surprisingly close to that of the much less crowded (C,H,),Mo,(CO),(phoran) as far as the environment of the M-MO core is concerned, but differs in the arrangement of the phoran ligand.
Optimum pump pulse selection for demultiplexer application of four-wave mixing in semiconductor laser amplifiers (1995)

We report on an analysis of four-wave mixing in semiconductor laser amplifiers used for demultiplexing time-division multiplexed data streams at ultra-high bit rates. The analysis is focused on the optimum control pulse energy and width with respect to the switching efficiency, channel crosstalk, and jitter tolerance. We use a simple model of the time resolved gain saturation and four-wave mixing. It turns out, that an optimum pulse energy exists with respect to the switching efficiency. The requirements on the pulse width are contrary for the channel crosstalk and the jitter tolerance. Results for an optimum system design are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Dendrimer Display of Tumor-Homing Peptides (2011)

In vivo selection of phage libraries that display random peptide sequences on their surface has yielded a number of peptides that specifically home to tumor tissue. In this study, two different peptides are introduced to synthetic dendritic scaffolds via oxime chemistry and the resulting compounds are analyzed for tumor homing. Modification of the dendritic wedge with a short, linear peptide that homes to clotted plasma proteins showed that a specific receptor in tumor tissue is recognized, but that the extravasation is likely affected by the size of the construct. In contrast, a positively charged cyclic peptide with cell penetrating properties was capable of directing the entire dendritic architecture toward a specific receptor in tumor lymphatics. These observations are in agreement with results previously reported for micelles and nanoparticles and emphasize the influence of peptide properties and overall size on the biodistribution of multivalent macromolecules.
Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting (2019)

The vaccine elicitation of broadly neutralizing responses is a central goal of HIV research. Recently, we elicited cross-clade neutralizing responses against the N terminus of the fusion peptide (FP), a critical component of the HIV-entry machinery. While the consistency of the elicited cross-clade neutralizing responses was good in mice, it was poor in guinea pigs: after seven immunizations comprising either envelope (Env) trimer or FP coupled to a carrier, serum from only one of five animals could neutralize a majority of a cross-clade panel of 19 wild-type strains. Such a low response rate-only 20%-made increasing consistency an imperative. Here, we show that additional Env-trimer immunizations could boost broad FP-directed neutralizing responses in a majority of immunized animals. The first boost involved a heterologous Env trimer developed from the transmitted founder clade C strain of donor CH505, and the second boost involved a cocktail that combined the CH505 trimer with a trimer from the BG505 strain. After boosting, sera from three of five animals neutralized a majority of the 19-strain panel and serum from a fourth animal neutralized 8 strains. We demonstrate that cross-reactive serum neutralization targeted the FP by blocking neutralization with soluble fusion peptide. The FP competition revealed two categories of elicited responses: an autologous response to the BG505 strain of high potency (~10,000 ID50), which was not competed by soluble FP, and a heterologous response of lower potency, which was competed by soluble FP. While the autologous response could increase rapidly in response to Env-trimer boost, the heterologous neutralizing response increased more slowly. Overall, repetitive Env-trimer immunizations appeared to boost low titer FP-carrier primed responses to detectable levels, yielding cross-clade neutralization. The consistent trimer-boosted neutralizing responses described here add to accumulating evidence for the vaccine utility of the FP site of HIV vulnerability.
Sclerosing Mesenteritis (2002)

Sclerosing MesenteritisDepiction by Multidetector CT and Three-Dimensional Volume RenderingLeo P. Lawler1, Denis M. McCarthy2, Elliot K. Fishman1 and Ralph Hruban2Audio Available | Share
Complex Lifestyle and Psychological Intervention in Knee Osteoarthritis: Scoping Review of Randomized Controlled Trials (2021)

Knee osteoarthritis (OA) causes pain, disability and poor quality of life in the elderly. The primary aim was to identify and map out the current evidence for randomised controlled trials (RCTs) on complex lifestyle and psychosocial interventions for knee OA. The secondary aim was to outline different components of complex lifestyle and psychosocial interventions. Our scoping review searched five databases from 2000 to 2021 where complex lifestyle or psychosocial interventions for patients with knee OA were compared to other interventions. Screening and data extraction were performed by two review authors independently and discrepancies resolved through consensus and in parallel with a third reviewer. A total of 38 articles were selected: 9 studied the effectiveness of psychological interventions; 11 were on self-management and lifestyle interventions; 18 looked at multifaceted interventions. This review highlights the substantial variation in knee OA interventions and the overall lack of quality in the current literature. Potential areas of future research, including identifying prognostic social factors, stratified care models, transdisciplinary care delivery and technology augmented interventions, have been identified. Further high-quality RCTs utilizing process evaluations and economic evaluation in accordance with the MRC guidelines are critical for the development of evidence-based knee OA programs globally.
High-Performance Implantable Bioelectrodes with Immunocompatible Topography for Modulation of Macrophage Responses (2022)

Implantable bioelectrodes enable precise recording or stimulation of electrical signals with living tissues in close contact. However, their performance is frequently compromised owing to inflammatory tissue reactions, which macrophages either induce or resolve by polarizing to an inflammatory (M1) or noninflammatory (M2) phenotype, respectively. Thus, we aimed to fabricate biocompatible and functional implantable conductive polymer bioelectrodes with optimal topography for the modulation of macrophage responses. To this end, we produced heparin-doped polypyrrole (PPy/Hep) electrodes of different surface roughness, with <i>R</i><sub>a</sub> values from 5.5 to 17.6 nm, by varying the charge densities during electrochemical synthesis. <i>In vitro</i> culture revealed that macrophages on rough PPy/Hep electrodes preferentially polarized to noninflammatory phenotypes. In particular, PPy/Hep-900 (<i>R</i><sub>a</sub> = 14 nm) was optimal with respect to electrochemical properties and the suppression of inflammatory M1 polarization. <i>In vivo</i> implantation indicated that PPy/Hep-900 significantly reduced macrophage recruitment, suppressed inflammatory polarization, and mitigated fibrotic tissue formation. In addition, the implanted PPy/Hep-900 electrodes could successfully record electrocardiographic signals for up to 10 days without substantial decreases in sensitivity, while other electrodes substantially lost their signal sensitivity during implantation. Altogether, we demonstrate that modulating the surface features of PPy/Hep can benefit the design and applications of high-performance and high-biocompatibility bioelectrodes.
Supplementary Data S1-S9 from Predictive Biomarkers for Adjuvant Capecitabine Benefit in Early-Stage Triple-Negative Breast Cancer in the FinXX Clinical Trial (2023)

&lt;p&gt;Data S1 shows the gene content of the 770 gene panel, Data S2-S3 show the expression scores for different gene and metagenes, Data S4-S7 show univariate analyses for different genes and metagenes according to treatment arm, Data S8-S9 show functional annotation and enrichment analysis for genes associated with capecitabine benefit&lt;/p&gt;
<I>In situ</I> SEM Observation on Microscopic Deformation of Particle Reinforced Aluminum Matrix Composites (1994)

In order to directly observe microscopic behavior of particles, matrix and their interfaces of particle reinforced metal matrix composites during static loading, the in situ tensile test in the scanning electron microscope equipped with a deformation stage was examined for the Al2O3 particle reinforced aluminum matrix composite produced with the melt stirring method. Two types of sheet tensile specimens were investigated, the one has a small hole in the center of the general tensile specimen and the another is reduced in width with a round radius. The stress and strain distributions in their specimens were analyzed by an FEM calculation and compared with observed microcracks distribution. It is possible to observe only microstructural degradation owing to structural defects without the influence of stress localization by using the latter specimen, because the stress distribution in the center part is almost homogeneous in the specimen. Some microcracks owing to the interface debonding and the particle fracture are found at early loading point before maximum loading. The microcracks do not propagate in the matrix because of its ductility, but a number of new microcracks are initiated during increasing load.
A dual fitness function genetic algorithm and application in aerodynamic inverse design (2000)

A dual fitness function, which provides a threshold distinguishing the global optimum basin of a fitness function from local optimum basin, is applied to improve the simple genetic algorithms. The resultant genetic algorithm, with the mutation probability being adjusted adaptively, is of much greater global optimization capability. The new algorithm has been applied to a geometry inverse design of a practical aerodynamic diffuser blade. The numerical simulations show that it is not only feasible but also reliable and efficient.
Tailor-made Surface Properties of Particles with a Hydrophilic or Hydrophobic Polymer Shell Mediated by Supercritical CO2 (2007)

Controlling the surface characteristics of inorganic materials with an organic shell is of great interest for control of the properties of the final material. A challenge is thus to be able to deposit a polymer shell with different solvation properties onto the surface of inorganic particles and to have a good control of the thickness of the organic layer without a prefunctionalization of surfaces. We demonstrate, in this paper, a method for coating silica particles (170-550 nm), used as model substrates, with either a hydrophilic (polyethylene glycol) or a hydrophobic polymer (polybutadiene hydroxy terminated) using a supercritical antisolvent process (precipitation from a compressed antisolvent). Several operating parameters were studied to control precisely the thickness of the deposited layer (from 2 to 30 nm), which was characterized using TEM, FESEM, XPS, and UV-visible techniques. This work demonstrates that supercritical antisolvent processes are powerful methods and good alternatives to conventional coating techniques toward the development of hybrid and/or core-shell nanomaterials.
Fatigue damage monitoring and analysis of aged asphalt concrete using acoustic emission technique (2021)

This paper presents an Acoustic Emission characterisation of the damage behaviour of asphalt concrete subjected to bending fatigue loading. An experimental campaign is carried out on an old asphalt concrete extracted from an in-service highway pavement, built-in 2001. Tests were performed in strain-controlled mode with an amplitude of 175 µstrain, a frequency of 25 Hz, and at 10°C. Failure criteria based on modulus decrease are analysed to determine the fatigue lifespan. Acoustic emission measurements are used to investigate the damage and failure processes. A network of eight piezoelectric sensors was used to acquire the acoustic signals. Therefore, different fatigue stages are identified based on the temporal evolution of acoustic activity. Hence, the event’s spatial location is presented to show the crack path propagation. The results show that sensors located at the bottom of the sample register more acoustic activity. The locations of acoustic events were in good agreement with the mechanical background calculations.
Differential effects of vasodilators on the mobilization of calcium pools during contractions of rabbit ear artery induced by noradrenaline and high potassium (1984)

The effects of some vasodilators on the mobilization of different Ca2+ pools during contractions produced by noradrenaline and high K+ medium in rabbit ear artery has been investigated. Sodium nitrite was much more effective in antagonizing high K+-stimulated Ca2+ fluxes through the potential-dependent Ca2+ channels than noradrenaline-induced mobilization of intracellular Ca2+ stores or Ca2+ fluxes through receptor-operated channels. Papaverine was only slightly more active on contractions sustained by influx of extracellular Ca2+ (through potential-dependent channels and receptor-operated channels) than on those sustained by intracellular Ca2+. Verapamil and nifedipine were much more effective in antagonizing contractions sustained by Ca2+ entry through potential-dependent channels than through receptor-operated channels. Nifedipine was completely ineffective in antagonizing noradrenaline-induced mobilization of intracellular Ca2+ stores while verapamil had a limited inhibitory action in high concentrations. Phentolamine was equieffective in antagonizing both types of noradrenaline-induced contractions while having no effect on high K+-induced tonic contraction.
Practical Regioselective Bromination of Azaindoles and Diazaindoles. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing (2011)

DNA methylation is the most common form of DNA modification in prokaryotic and eukaryotic genomes. We have applied the method of single-molecule, real-time (SMRT®) DNA sequencing that is capable of direct detection of modified bases at single-nucleotide resolution to characterize the specificity of several bacterial DNA methyltransferases (MTases). In addition to previously described SMRT sequencing of N6-methyladenine and 5-methylcytosine, we show that N4-methylcytosine also has a specific kinetic signature and is therefore identifiable using this approach. We demonstrate for all three prokaryotic methylation types that SMRT sequencing confirms the identity and position of the methylated base in cases where the MTase specificity was previously established by other methods. We then applied the method to determine the sequence context and methylated base identity for three MTases with unknown specificities. In addition, we also find evidence of unanticipated MTase promiscuity with some enzymes apparently also modifying sequences that are related, but not identical, to the cognate site.
Fluorescence Tomography and Magnetic Resonance Imaging of Myocardial Macrophage Infiltration in Infarcted Myocardium In Vivo (2007)

Noninvasive imaging of myocardial macrophage infiltration has been shown to be possible by both fluorescence tomography and magnetic resonance imaging. This could be of significant value in both the research and clinical settings. The techniques developed could also be used to image other existing fluorescent and magnetofluorescent probes and could significantly expand the role of fluorescence imaging in the heart.
ChemInform Abstract: Synthesis of New 3′‐Deoxyribonucleosides Employing the Acid‐Catalyzed Fusion Method. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Interference Mitigating Satellite Broadcast Receiver using Reduced\n Complexity List-Based Detection in Correlated Noise (2014)

The recent commercial trends towards using smaller dish antennas for\nsatellite receivers, and the growing density of broadcasting satellites,\nnecessitate the application of robust adjacent satellite interference (ASI)\ncancellation schemes. This orbital density growth along with the wider\nbeamwidth of a smaller dish have imposed an overloaded scenario at the\nsatellite receiver, where the number of transmitting satellites exceeds the\nnumber of receiving elements at the dish antenna. To ensure successful\noperation in this practical scenario, we propose a satellite receiver that\nenhances signal detection from the desired satellite by mitigating the\ninterference from neighboring satellites. Towards this objective, we propose a\nreduced complexity list-based group-wise search detection (RC-LGSD) receiver\nunder the assumption of spatially correlated additive noise. To further enhance\ndetection performance, the proposed satellite receiver utilizes a newly\ndesigned whitening filter to remove the spatial correlation amongst the noise\nparameters, while also applying a preprocessor that maximizes the\nsignal-to-interference-plus-noise ratio (SINR). Extensive simulations under\npractical scenarios show that the proposed receiver enhances the performance of\nsatellite broadcast systems in the presence of ASI compared to existing\nmethods.\n