gebhart/patrepeval huggingface dataset:
75. BONY INCREASED-OFFSET REVERSE SHOULDER ARTHROPLASTY (BIO RSA): A BIOLOGLIC SOLUTION TO SCAPULAR NOTCHING, PROSTHETIC INSTABILITY AND LIMITED SHOULDER ROTATION (2011)

Purpose: We hypothesized that lateralization of the RSA, with a glenoid bone graft taken from the osteotomised humeral head, would prevent those problems without increasing torque on the glenoid component by keeping the center of rotation within the glenoid. The objectives of this study were to describe the results of the first 12 patients that underwent a bony increased-offset RSA (BIO RSA).

Method: Thirty-six shoulders in 34 consecutive patients with cuff tear arthritis (mean age 72 years, range 52–86 years) received a BIO RSA, consisted of a RSA incorporating an autogenous humeral head bone graft placed beneath the glenoid baseplate. A baseplate with a lengthened central peg (+25 mm) was inserted in the glenoid vault, securing the bone graft beneath the baseplate and screws. All patients underwent clinical and radiographic (computed tomography) review at a minimum 1-year follow-up.

Results: All patients were satisfied or very satisfied and all had no or slight pain. Mean active elevation increased from 72° to 142° (p 0.05). Constant Score improved from 27 to 63 points (p<0.05). The Subjective Shoulder Value (SSV) increased from 27% to 73% (p<0.05). Radiographically, the graft healed to the native glenoid in all cases and no graft resorption under the baseplate was observed. Complications included one patient with scapular notching (stage 1) and one patient with previous radiotherapy had a deep infection. No postoperative instability, and no glenoid loosening were observed.

Conclusion: The use of an autologous bone graft harvested from the humeral head can lateralize the center of rotation of a RSA while keeping the center of rotation at the glenoid bone-prosthesis interface. The clinical advantages of a BIO RSA are a decrease in scapular notching, enhanced stability and mobility, and improved shoulder contour while keeping the center of rotation at the glenoid bone-prosthesis interface. This bony lateralization allows maintenance of the principles of Grammont and seems to be more appropriate than prosthetic lateralization. These promising early results of this novel procedure warrant further investigation.
Exploring Clinical Time Series Forecasting with Meta-Features in Variational Recurrent Models (2020)

Clinical time series are known for irregular, highly-sporadic and strongly-complex structures and are consequently difficult to model by traditional state-space models. In this paper, we investigate the potential of applying variational recurrent neural networks (VRNNs) for forecasting clinical time series extracted from electronic health records (EHRs) of patients. Variational recurrent neural networks (VRNNs) combine recurrent neural networks (RNNs) and variational inference (VI) and are state-of-the-art methods to model highly-variable sequential data such as text, speech, time series and multimedia signals in a generative fashion. We propose to incorporate multiple correlated time series to improve the forecasting of VRNNs. The selection of these correlated time series is based on the similarity of the supplementary medical information e.g., disease diagnostics, ethnicity and age etc. between the patients. We evaluate the effectiveness of utilizing such supplementary information with root mean square error (RMSE), on clinical benchmark data-set "Medical Information Mart for Intensive Care (MIMIC III)" for multi-step-ahead prediction. We further perform subjective analysis to highlight the effects of the similarity of the supplementary medical information on individual temporal features e.g., Systolic Blood Pressure (SBP), Heart Rate (HR) etc. of the patients from the same data-set. Our results clearly show that incorporating the correlated time series based on the supplementary medical information can help improving the accuracy of the VRNNs for clinical time series forecasting.
Performance Evaluation of Rel-16 5G-MBMS (2021)

This paper introduces the performance evaluation results of 5G multimedia broadcast multicast services (5G-MBMS), which can support terrestrial broadcasting based on a 3GPP network. To meet 5G broadcasting requirements from terrestrial broadcasters, 3GPP improved the capability of release (Rel-) 14 LTE-based further evolved MBMS (FeMBMS) so that it standardized 5G-MBMS in Rel-16. We compare the differences between FeMBMS and 5G-MBMS in terms of numerology and performance of physical channels based on computer simulations. The properties and decoding performance of the physical-layer of the 5G- MBMS show that it can guarantee terrestrial broadcasting reliability in various environments. Our laboratory test shows the delivery of media contents through an FPGA-based 5G-MBMS transceiver.
Electron crystallography and organic materials with non‐linear optical properties (1999)

Abstract Results of electron microscopic studies of crystal structures of a number of bis‐benzylidene cyclohexanones are presented. It is shown that some of these compounds are efficient crystalline non‐linear optically active (NLO) chromophores with second harmonic generation (SHG) properties. Appropriately functionalized chromophores of this type can be used as a polycondensation comonomer to produce partly crystalline main‐chain NLO‐active polymers. Electron diffraction crystal structural data, obtained for very small crystals, allowed us to get reasonable estimations of macroscopic crystal NLO‐coefficients, relating quantum‐chemically calculated molecular first hyperpolarizability components to crystal axes.
Improved uniformity of sensor gratings in offset core fibers with fiber lensing mitigation (2016)

We report on improved spatial uniformity of sensor grating arrays in offset and multicore fibers. We show improvement over conventional side writing in such fibers, in which cores offset from the center of the fiber exhibit grating strength variations due to lensing at the fiber surface. Such strength variations can degrade the performance of sensing systems that rely on continuous scattering from offset cores along a fiber. Our improved system uses multicore fibers whose coating is UV transparent and applies index matching materials to mitigate lensing aberrations. We show that it is capable of continuously inscribing gratings over any length of fiber.
Late Breaking Abstract - ACE2 expression in lower airway epithelial cells is increased with age and in males, but is less in asthma (2020)

<b>Introduction:</b> COVID-19 is responsible for a global pandemic that is complicated by acute lung injury, and death. The virus SARS-CoV-2 requires the ACE2 receptor and serine proteases to enter airway epithelial cells. We sought to determine what factors were associated with levels of ACE2 expression and how this related to people with asthma and chronic obstructive pulmonary disease (COPD). <b>Methods:</b> We obtained airway epithelial cells from 146 people, aged 2 to 89 from Perth and Newcastle. The Newcastle cohort were enriched with people with asthma and COPD. Gene expression for ACE2 and other genes potentially associated with SARS-CoV-2 cell entry were assessed by quantitative PCR and immunohistochemistry. <b>Results:</b> Increased gene expression for ACE2 from lower airway epithelial cells was associated with older age (p=0.02) and male sex (p=0.03), but not packet years smoked. When we compared gene expression between adults with asthma, COPD and healthy controls, mean ACE2 was lower in asthma p=0.01(Figure). Gene expression for Furin a protease that facilitates viral endocytosis was also lower in asthma (p=0.02), while ADAM-17, a disintegrin that has been shown to cleave ACE2 from the surface was increased p=0.02. We confirmed that ACE2 protein expression was lower in endobronchial biopsies from people with asthma. <b>Conclusions:</b> Increased ACE2 expression is seen in older people and males. While people with asthma appear to have reduced expression. Altered ACE2 expression in the lower airway may be an important factor in virus tropism to the lower airway.
Continuous and Scalable Synthesis of a Porous Organic Cage by Twin Screw Extrusion (TSE) (2020)

The continuous and scalable synthesis of a porous organic cage (CC3), obtained through a 10-component imine polycondensation between triformylbenzene and a vicinal diamine, was achieved using twin screw extrusion (TSE). Compared to both batch and flow syntheses, the use of TSE enabled the large scale synthesis of CC3 using minimal solvent and in short reaction times, with liquid-assisted grinding (LAG) also promoting window-to-window crystal packing to form a 3-D diamondoid pore network in the solid state. A new kinetically trapped [3+5] product was also observed alongside the formation of the targeted [4+6] cage species. Post-synthetic purification by Soxhlet extraction of the as-extruded ‘technical grade’ mixture of CC3 and [3+5] species rendered the material porous.
Phosphorylation of Thr695 and Thr850 on the myosin phosphatase target subunit: Inhibitory effects and occurrence in A7r5 cells (2005)

Major sites for Rho-kinase on the myosin phosphatase target subunit (MYPT1) are Thr695 and Thr850. Phosphorylation of Thr695 inhibits phosphatase activity but the role of phosphorylation at Thr850 is not clear and is evaluated here. Phosphorylation of both Thr695 and Thr850 by Rho-kinase inhibited activity of the type 1 phosphatase catalytic subunit. Rates of phosphorylation of the two sites were similar and efficacy of inhibition following phosphorylation was equivalent for each site. Phosphorylation of each site on MYPT1 was detected in A7r5 cells, but Thr850 was preferred by Rho-kinase and Thr695 was phosphorylated by an unidentified kinase(s).
An Exploration Methodology for Vliw Architecture Targeting Multimode Wireless Baseband Processing (2006)

The wide range of future and existing standards in wireless communications calls for flexible solutions. A way to introduce flexibility to digital radio systems is to replace hardwired components by programmable devices. This paper describes the exploration of a VLIW architecture targeting the domain of multimode wireless baseband processing. Target is to explore the tradeoff between flexibility, performance and power consumption. The Coware ® LISATek ™ tool suite for automated embedded processor design has been used to create a processor model with scalable number of functional units and RTL generation capability. Furthermore, a C-compilation framework based on IMPACT was adapted to enable the mapping of a Fast Fourier Transformation and parts of a SDM-OFDM receiver. The code was optimized with special instruction supported in C by intrinsic functions. To estimate the costs of the implemented optimization, the generated RTL has been synthesized in 90nm technology. It is shown that a wide energy-performance tradeoff can be ranged by varying the processor configurations. Moreover, by using special instructions for complex arithmetic, power consumption and execution time of the benchmarked kernels can be reduced by factor two. 1.
Peripartum cardiomyopathy (2013)

Different mechanisms have been investigated and give rise to promising therapeutic approach, which will be developed based on the new findings.
Supplementary Materials and Methods from Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS–Dependent Pancreatic Ductal Adenocarcinoma (2023)

&lt;p&gt;Supplementary Materials and Methods&lt;/p&gt;
The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes (2011)

The transcriptional coactivator PGC-1α is a potent regulator of skeletal muscle metabolism. Less is known about the structurally similar PGC-1α-related coactivator (PRC) that is enriched in myoblasts and adult skeletal muscle. The present study was designed to determine the effect of PRC on the metabolic profile of C2C12 myotubes. Overexpression of full-length PRC increased PRC gene expression by 2.7 ± 0.3-fold and protein content by 108 ± 5.3%. This modest elevation in PRC resulted in an increased rate of myoblast proliferation (61.5 ± 2.7%) and resulted in myotubes characterized by increased MyoD (18.2 ± 0.52%) and myosin heavy chain (15.4 ± 3.13%) protein. PRC overexpressing myotubes showed increases in mRNA for some-COX4 (2.6 ± 0.18-fold), ATP5B (2.7 ± 0.34-fold) cytochrome c (5.1 ± 0.68-fold)-but not all, MTCO1 (0.61 ± 0.18-fold) and HAD (0.98 ± 0.36-fold) mitochondrial genes, as well as a significant increase in cytochrome-c (28.7 ± 7.02%) protein content. The enzyme activity of the electron transport chain (ETC) complex IV (3.7 ± 0.01-fold) and citrate synthase (2.1 ± 0.14-fold) was increased by PRC, as was the mtDNA:nucDNA ratio (11 ± 0.3%). PRC increased cellular respiration (142%), basal (197%) and insulin-stimulated (253%) glucose uptake, as well as palmitate uptake (28.6 ± 3.31%) and oxidation (31.1 ± 2.17%). Associated with these changes in function, PRC overexpression increased GLUT4 mRNA (4.5 ± 0.22-fold) and protein (13.8 ± 2.08%) and CPT1 protein (28.9 ± 4.23%). Electrical stimulation of C2C12 myotubes resulted in a transient increase in PRC mRNA that was smaller (2.1 ± 0.3-fold vs. 4.4 ± 0.23-fold) and occurred earlier (3 h vs. 6 h) than PGC-1α. Collectively, our data show that PRC promotes skeletal muscle myogenesis and metabolism in vitro, thus identifying PRC as a functional skeletal muscle coactivator capable of regulating mitochondrial substrate utilization and respiration.
Restoration of hexosaminidase A activity in human Tay-Sachs fibroblasts via adenoviral vector-mediated gene transfer. (1996)

Tay-Sachs disease (TSD) is a lysosomal storage disease due to hexosaminidase A deficiency caused by mutations in the gene for alpha-chain (Hex alpha). A human Hex alpha cDNA was subcloned into the adenoviral plasmid pAdRSV. Hex alpha. Replication-deficient adenovirus was generated by homologous recombination in 293 cells. Human fibroblasts from a patient suffering from TSD were infected with the recombinant adenovirus. TSD fibroblasts expressing the recombinant alpha-chain had an enzyme activity on the natural substrate ranging from 40 to 84% of the normal. The corrected cells secreted up to 25 times more Hex alpha than control fibroblasts. The Hex alpha encoded by the adenovirus was shown to be correctly transported into the lysosomes and to normalize the impaired degradation of GM2 ganglioside in TSD fibroblasts.
Modeling and experimental validation of the learning process during closed-loop BMI operation (2009)

This paper presents a model and experimental validation of the learning process during operation of a closed-loop brain-machine interface. The model consists of a population of simulated cortical neurons, a decoder that transforms neural activity into motor output, a feedback controller whose role is to reduce the error based on an error-descent algorithm, and an open-loop controller whose parameters are updated based on the corrections made by the feedback controller. Using this approach, we show that the population of neurons can learn the inverse model of the decoder. Then, we validate the model by comparing its predictions with real experimental data recorded from a macaque monkey. Such a simulation tool will be useful to predict the behavior of a closed-loop BMI and in the design of optimal decoders.
Treatment of Descemet's membrane detachment after primary Descemet's stripping automated endothelial keratoplasty during surgery using intraoperative optical coherence tomography (2022)

iOCT-guided surgical interventions provide a safe and accurate approach for treating intraoperative complications in eyes with a history of DSAEK.
Polymer Chemistry for Improving Lithium Metal Anodes (2019)

Abstract Lithium metal anode based rechargeable batteries (LMBs) are regarded as a highly appealing alternatives to replace state‐of‐the‐art lithium ion batteries (LIBs) for applications that demand higher energy density. Due to the highly reactive nature of metallic lithium and the related challenges with regard to dendrite issues at the anode, and electrolyte and cathode design, the industrial success of LMBs is yet to be safely achieved. Traditionally, in an LMB, the role of polymeric components is mostly limited to separators and cathode binders. With the advancement in polymer chemistry and its growing applications in materials science, it is now recognized that functional polymers can greatly improve the practical performance of an LMB. This paper discusses some representative studies, in order to demonstrate how various macromolecular approaches could be adopted to improve LMBs especially concerning the anode side, including electrolyte and artificial solid electrolyte interphase.
OS0317 Deformation twinning model of HCP metals and its application to finite crystal plasticity FEM (2012)

A thermodynamics-based constitutive model, which accounts for both crystallographic slip and deformation twinning, is developed for a single crystal of hcp metals within the framework of finite crystal plasticity. While the volume fractions of stress-free twin deformations are introduced as internal variables, the free-energy involves the bulk energy of separate phases and the surface energy at twin interfaces, which are introduced as functions of the internal variables, in addition to the standard hardening-related energy in crystal plasticity framework. After the formulation is described in detail, a series of numerical examples is presented to verify the performance of the proposed model in predicting the deformation twinning, the successive deformation process and the twinning-induced stress responses. The results are studied with reference to the theoretical consequences and the experimental results reported in the literature.
Charging Dynamics of Single InGaAs Quantum Dots under Resonant Excitation (2017)

We investigate the rates of charge state fluctuation in single InGaAs quantum dots under resonant excitation and with an additional low-power above-band laser. Multiple charging processes are identified.
Automatic plane adjustment of orthopedic intraoperative flat panel detector CT-volumes (2022)

<b>Purpose:</b> To assess the result in orthopedic trauma surgery, usually three-dimensional volume data of the treated region is acquired. With mobile C-arm systems, these acquisitions can be performed intraoperatively, reducing the number of required revision surgeries. However, the acquired volumes are typically not aligned to the anatomical regions. Thus, the multiplanar reconstructed (MPR) planes need to be adjusted manually during the review of the volume. To speed up and ease the workflow, an automatic parameterization of these planes is needed. <b>Approach:</b> We present a detailed study of multitask learning (MTL) regression networks to estimate the parameters of the MPR planes. First, various mathematical descriptions for rotation, including Euler angle, quaternion, and matrix representation, are revised. Then, two different MTL network architectures based on the PoseNet are compared with a single task learning network. <b>Results:</b> Using a matrix description rather than the Euler angle description, the accuracy of the regressed normals improves from 7.7 deg to 7.3 deg in the mean value for single anatomies. The multihead approach improves the regression of the plane position from 7.4 to 6.1 mm, whereas the orientation does not benefit from this approach. Thus, the achieved accuracy meets the reported interrater variance in similarly complex body regions of up to 6.3 deg for the normals and up to 9.3 mm for the plane position. <b>Conclusions:</b> The use of a multihead approach with shared features leads to more accurate plane regression compared with the use of individual networks for each task. It also improves the angle estimation for the ankle region. The reported results are in the same range as manual plane adjustments. The use of a combined network with shared parameters requires less memory, which is a great benefit for the implementation of an application for the surgical environment.
On the potential of a new IVUS elasticity modulus imaging approach for detecting vulnerable atherosclerotic coronary plaques:in vitrovessel phantom study (2010)

Peak cap stress amplitude is recognized as a good indicator of vulnerable plaque (VP) rupture. However, such stress evaluation strongly relies on a precise, but still lacking, knowledge of the mechanical properties exhibited by the plaque components. As a first response to this limitation, our group recently developed, in a previous theoretical study, an original approach, called iMOD (imaging modulography), which reconstructs elasticity maps (or modulograms) of atheroma plaques from the estimation of strain fields. In the present in vitro experimental study, conducted on polyvinyl alcohol cryogel arterial phantoms, we investigate the benefit of coupling the iMOD procedure with the acquisition of intravascular ultrasound (IVUS) measurements for detection of VP. Our results show that the combined iMOD-IVUS strategy: (1) successfully detected and quantified soft inclusion contours with high positive predictive and sensitivity values of 89.7 ± 3.9% and 81.5 ± 8.8%, respectively, (2) estimated reasonably cap thicknesses larger than ∼300 µm, but underestimated thinner caps, and (3) quantified satisfactorily Young's modulus of hard medium (mean value of 109.7 ± 23.7 kPa instead of 145.4 ± 31.8 kPa), but overestimated the stiffness of soft inclusions (mean Young`s moduli of 31.4 ± 9.7 kPa instead of 17.6 ± 3.4 kPa). All together, these results demonstrate a promising benefit of the new iMOD-IVUS clinical imaging method for in vivo VP detection.
Clinical Comparison of Natural LH-RH, Synthetic LH-RH, and Two Analogues of LH-RH (1974)

Two analogues of LH-RH as well as pure, natural LH-RH were compared with synthetic LH-RH in normal men. The 9-ethylamide LH-RH caused increments in plasma levels of LH and FSH comparable to those caused by synthetic LH-RH given at double the dose level. About twice the amount of the 5-phenylalanine analogue, as compared with synthetic LH-RH was required to release similar amounts of LH and FSH. Prolongation of action was found in some subjects by the addition of 16% gelatin to the im injections and mean maximum peaks may have been delayed when the 9-ethylamide LH-RH was given as a rapid iv injection. Pure natural LH-RH was as potent as the synthetic decapeptide.
Long term effect of aflatoxin B1 on lipid peroxidation in rat liver and kidney: effect of picroliv and silymarin (2001)

Aflatoxin B(1) (AFB(1)) is a potent hepatotoxic and hepatocarcinogenic mycotoxin. The mechanism of cellular damage caused by AFB(1) has not been fully elucidated. Lipid peroxidation is one of the main manifestations of oxidative damage and has been found to play an important role in the toxicity and carcinogenesis of many carcinogens. The present investigation aims at assessing the comparative antioxidant effect of picroliv, a standardized iridoid glycoside fraction of Picrorhiza kurroa and silymarin, a well known standard hepatoprotective, on aflatoxin B(1) induced lipid-peroxidation in rat liver and kidney. Marked increases in lipid peroxide levels and a concomitant decrease in enzymic antioxidant levels were observed in aflatoxin B(1) (2 mg/kg, i.p) -toxicated rats, while drug (picroliv and silymarin both) treatment reversed the condition to near normal levels. The effects of picroliv and silymarin were comparable.