gebhart/patrepeval huggingface dataset:
Impact of tantalum composition in TaC/HfSiON gate stack on device performance of aggressively scaled CMOS devices with SMT and strained CESL (2008)

We report TaC <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> /HfSiON gate stack CMOS device with simplified gate 1 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> process from the viewpoints of fixed charge generation and its impact on the device performance. Moderate Metal Gate / High-K dielectric (MG/HK) interface reaction is found to be a dominant factor to improve device performance. By optimizing TaC <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> composition, fixed charge free TaC <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> /HfSiON device is successfully fabricated. Also, we have demonstrated that the strain effect in deeply scaled devices can be enhanced by eliminating the fixed charges in HfSiON, for the first time. Utilizing Stress Memorization Technique (SMT) and strained Contact Etch Stop Layer (CESL), L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> = 35 nm high performance TaC <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> /HfSiON devices is achieved.
Prognostic significance of IKZF1 deletions and IKZF1 plus profile in children with B‐cell precursor acute lymphoblastic leukemia treated according to the ALL‐IC BFM 2009 protocol (2022)

The strongest predictors of outcome in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are minimal residual disease (MRD) and specific molecular abnormalities. One unfavorable prognostic factor is the presence of IKZF1 gene aberrations, particularly when co-occurring with high MRD level at the end of induction treatment. The present study determines the predictive value of a recently-defined IKZF1-plus (IKZF1<sup>plus</sup> ) microdeletion profile in 373 children with BCP-ALL treated according to the ALL-intercontinental Berlin-Frankfurt-Munster protocol 2009 protocol. IKZF1-wild type (IKZF1<sup>wt</sup> ) patients demonstrated lower leukemic burden parameters than those carrying IKZF1 deletion (IKZF1<sup>del</sup> [n = 26, 7.0%]) or IKZF1<sup>plus</sup> pattern (n = 34, 9.1%): (i) median blast percentage at diagnosis (78.0% vs. 86.9% vs. 86.0%; p = 0.021); (ii) median MRD level at day 15 of induction protocol (0.3% vs. 2.1% vs. 0.8%; p = 0.011); (iii) poor steroid response (7.6% vs. 26.5% vs. 12.5%; p = 0.010). Minimal residual disease level at day 33 (MRD33) exceeding 10<sup>-4</sup> was more frequently observed in both the IKZF1<sup>del</sup> and IKZF1<sup>plus</sup> subgroups than in IKZF1<sup>wt</sup> patients (n = 9 [36.0%] vs. n = 13 [41.9%] vs. n = 70 [24.0%], p = 0.051). IKZF1<sup>plus</sup> individuals showed a tendency for a lower MRD reduction between day 15 and 33 compared to IKZF1<sup>del</sup> patients (p = 0.124). IKZF1<sup>del</sup> and IKZF1<sup>plus</sup> patients showed decreased relapse-free survival (HR [95%CI] for IKZF1<sup>wt</sup> as reference = 2.72 [1.21-6.11] and 2.00 [0.87-4.49], respectively, p = 0.023). Both genetic markers including IKZF1<sup>del</sup> and IKZF1<sup>plus</sup> microdeletion profile provide additional predictive value of treatment outcome in childhood BCP-ALL and may contribute to more efficient patient stratification; the same is true in MRD guided protocols, which are based on flow cytometric measurements on day 15 of induction protocol.
Troubleshooting chronic conditions in large IP networks (2008)

Chronic network conditions are caused by performance impairing events that occur intermittently over an extended period of time. Such conditions can cause repeated performance degradation to customers, and sometimes can even turn into serious hard failures. It is therefore critical to troubleshoot and repair chronic network conditions in a timely fashion in order to ensure high reliability and performance in large IP networks. Today, troubleshooting chronic conditions is often performed manually, making it a tedious, time-consuming and error-prone process.
Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids (2023)

Fluorescent reporter pluripotent stem cell (PSC) derived retinal organoids are powerful tools to investigate cell type-specific development and disease phenotypes. When combined with live imaging, they enable direct and repeated observation of cell behaviors within a developing retinal tissue. Here, we generated a human cone photoreceptor reporter line by CRISPR/Cas9 genome editing of WTC11-mTagRFPT-LMNB1 human induced pluripotent stem cells (iPSCs) by inserting enhanced green fluorescent protein (EGFP) coding sequences and a 2A self-cleaving peptide at the N-terminus of <i>Guanine Nucleotide-Binding Protein Subunit Alpha Transducin 2</i> (<i>GNAT2</i>). In retinal organoids generated from these iPSCs, the GNAT2-EGFP allele robustly and exclusively labeled both immature and mature cones starting at culture day 34. Episodic confocal live imaging of hydrogel immobilized retinal organoids allowed tracking of morphological maturation of individual cones for >18 weeks and revealed inner segment accumulation of mitochondria and growth at 12.2 cubic microns per day from day 126 to day 153. Immobilized GNAT2-EGFP cone reporter organoids provide a valuable tool for investigating human cone development and disease.
Organic Color Center Platform for Cancer Diagnosis (2021)

Organic color centers (OCC), synthetic defects incorporated into single-walled carbon nanotubes, feature extraordinary traits that make them an ideal platform for biochemical sensing applications. The OCC-induced fluorescence peak is tunable and extremely sensitive to the local microenvironment around the covalent functional group. Depending on the chemical nature of the functional group that induces each OCC, the fluorescence features can be systematically controlled. Based on the chemical tunability and sensitivity of OCCs, we construct OCC-based nanosensors that enables multiplexed sensing of bioanalytes in serum. The diverse spectral responses, processed by data analytics, enables disease identification.
Advanced multilayer resilience scheme with optical restoration for IP-over-DWDM core networks (2012)

Future IP-over-DWDM networks improve economics not only from eliminating grey interfaces substituted by coloured interfaces directly plugged into the packet routers. An even major leverage reducing cost of a traditionally over-dimensioned packet network can be attributed to architectural aspects including advanced multilayer resilience. This is enabled by newly available, flexible optical technology allowing a more dynamic mode of operation of IP-over-DWDM networks. The flexible optical layer can be used to offer service-differentiated resilience combining IP protection with optical restoration in IP-over-Optical networks. By this approach, higher interface utilization can be achieved reducing capital expenditures. In addition, this also improves the overall network availability and reduces operational expenditures. After a short overview on the key enabling technologies for flexible IP-over-DWDM interworking, the authors provide guidelines for the cost-efficient IP topology design of multilayer IP-over-DWDM core networks and show that for a German backbone reference network the combination of IP A/B-plane protection with optical restoration requires 24 - 27% fewer line interfaces compared to the multilayer optimized bypass network design.
Welding Distortion Analysis of Hull Blocks using Equivalent Load Method Based on Inherent Strain (2012)

Welding deformation reduces the dimensional accuracy of ship hull blocks and decreases productivity due to the correction work. Prediction and minimizing of welding distortion at the design stage will lead to higher quality as well as higher productivity. Therefore, it is strongly required to develop an effective method to accurately predict the weld distortion of hull blocks considering the fabrication sequences. In the case of hull block welding work in shipyard, the welding process of curved stiffened plate has large amounts of workload. This paper suggests an efficient method for predicting the welding deformation of stiffened curved plates based on the inherent strain theory combined with the finite element method. The equivalent load was determined by integrating inherent strain components which are calculated in the vicinity of heat affected zone using the highest temperature and the degree of restraint. The welding distortion of curved stiffened panels under equivalent load are calculated by elastic analysis and compared with that by intensive elasto-plastic finite element analysis. It is verified that the proposed method has a high efficiency and accuracy. Keywords: Welding deformation; Curved stiffened plate; Inherent
Continuous Propagation: Layer-Parallel Training (2018)

Continuous propagation is a parallel technique for training deep neural networks with batch size one at full utilization of a multiprocessor system. It enables spatially distributed computations on emerging deep learning hardware accelerators that do not impose programming limitations of contemporary GPUs. The algorithm achieves model parallelism along the depth of a deep network. The method is based on the continuous representation of the optimization process and enables sustained gradient generation during all phases of computation. We demonstrate that in addition to its increased concurrency, continuous propagation improves the convergence rate of state of the art methods while matching their accuracy.
Supplementation with oral probiotic bacteria maintains cutaneous immune homeostasis after UV exposure. (2007)

Probiotic bacteria have been shown to modulate the immune system of the gut and protect against infectious and inflammatory diseases of the gastro-intestinal tract. Ultraviolet radiation (UVR) is known to alter the cutaneous and systemic immune systems implicated in the development of skin tumors. In this study we investigated whether oral probiotics are able to modulate the immune system of the skin using hairless Skh:hr1 mice exposed to an acute dose of UVR. We show that nutritional supplementation with Lactobacillus johnsonii (La1) at 10(8) cfu/day for 10 days was able to protect against the UVR-induced suppression of contact hypersensitivity, the decreased epidermal Langerhans cell density and the increased IL-10 serum levels. In the absence of UV exposure, probiotic bacteria had no detectable effect on the immune system of the skin, thus acting only to re-establish skin homeostasis. In conclusion, our data demonstrate that ingested probiotic bacteria can maintain cutaneous immune capacity after UV exposure.
Size independent blue luminescence in nitrogen passivated silicon nanocrystals (2012)

Abstract The photoluminescent properties of allylamine terminated silicon nanocrystals (Si‐NCs) are investigated. Chloride surface terminated Si‐NCs of different sizes react with allylamine yielding NCs that exhibit size independent blue luminescent NCs. NCs were characterized using X‐ray diffraction, Fourier transformed infrared spectroscopy, photoluminescence spectroscopy, and dynamic light scattering. Reaction scheme summarizing surface modification approach used for the present study. magnified image
Efficient purification of labile and volatile reaction products by near-critical fluid chromatography (NCFC) (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEfficient purification of labile and volatile reaction products by near-critical fluid chromatography (NCFC)Tianmin Xie, Donald Wiesler, Paul A. David, and Milos NovotnyCite this: J. Org. Chem. 1989, 54, 17, 4213–4215Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/jo00278a041https://doi.org/10.1021/jo00278a041research-articleACS PublicationsRequest reuse permissionsArticle Views46Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Aspergillus fumigatus Cell Wall Promotes Apical Airway Epithelial Recruitment of Human Neutrophils (2019)

<i>Aspergillus fumigatus</i> is a ubiquitous fungal pathogen capable of causing multiple pulmonary diseases, including invasive aspergillosis, chronic necrotizing aspergillosis, fungal colonization, and allergic bronchopulmonary aspergillosis. Intact mucociliary barrier function and early airway neutrophil responses are critical for clearing fungal conidia from the host airways prior to establishing disease. Following inhalation, <i>Aspergillus</i> conidia deposit in the small airways, where they are likely to make their initial host encounter with epithelial cells. Challenges in airway infection models have limited the ability to explore early steps in the interactions between <i>A. fumigatus</i> and the human airway epithelium. Here, we use inverted air-liquid interface cultures to demonstrate that the human airway epithelium responds to apical stimulation by <i>A. fumigatus</i> to promote the transepithelial migration of neutrophils from the basolateral membrane surface to the apical airway surface. Promoting epithelial transmigration with <i>Aspergillus</i> required prolonged exposure with live resting conidia. Swollen conidia did not expedite epithelial transmigration. Using <i>A. fumigatus</i> strains containing deletions of genes for cell wall components, we identified that deletion of the hydrophobic rodlet layer or dihydroxynaphthalene-melanin in the conidial cell wall amplified the epithelial transmigration of neutrophils, using primary human airway epithelium. Ultimately, we show that an as-yet-unidentified nonsecreted cell wall protein is required to promote the early epithelial transmigration of human neutrophils into the airspace in response to <i>A. fumigatus</i> Together, these data provide critical insight into the initial epithelial host response to <i>Aspergillus</i>.
Analytical and Experimental Validation of Robustness of the Current Mirrors to EMI (2017)

This paper presents two electromagnetic interference (EMI) resisting current mirror topologies that use a linearization technique to filter out the EMI without producing any offset at the output. A proposed current mirror illustrating the linearization concept is implemented in standard 0.18 μm mixed-mode CMOS technology. Measurement results show that for a frequency range of 10 kHz-10 MHz, the EMI-induced offset current produced by the proposed current mirror is negligible as compared to the traditional current mirror.
Development of Automatic Magnification Calibration Function for Scanning Transmission Electron Microscope (2005)

Extract HTML view is not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button. Extended abstract of a paper presented at Microscopy and Microanalysis 2005 in Honolulu, Hawaii, USA, July 31--August 4, 2005
Nickel‐Catalyzed Coupling of Alkenes, Aldehydes, and Silyl Triflates (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Deep Learning the City : Quantifying Urban Perception At A Global Scale (2016)

Computer vision methods that quantify the perception of urban environment are increasingly being used to study the relationship between a city's physical appearance and the behavior and health of its residents. Yet, the throughput of current methods is too limited to quantify the perception of cities across the world. To tackle this challenge, we introduce a new crowdsourced dataset containing 110,988 images from 56 cities, and 1,170,000 pairwise comparisons provided by 81,630 online volunteers along six perceptual attributes: safe, lively, boring, wealthy, depressing, and beautiful. Using this data, we train a Siamese-like convolutional neural architecture, which learns from a joint classification and ranking loss, to predict human judgments of pairwise image comparisons. Our results show that crowdsourcing combined with neural networks can produce urban perception data at the global scale.
Optical quality investigation of urea crystals (1993)

The results of the two-dimensional theory of four-wave mixing (AIM) in the double phase-conjugate mirror geometry are compared with the experiment in a cubic Photorefractive BinTiao crystal. It is shown experimentally that this scheme can he used to determine the averaged surface relief of a scattering object.
Human heat shock protein (Hsp) 90 interferes with Neisseria meningitidis adhesin A (NadA)-mediated adhesion and invasion (2011)

NadA (N eisseria meningitidisadhesin A), a meningococcal surface protein, mediates adhesion to and invasion of human cells, an activity in which host membrane proteins have been implicated. While investigating these host factors in human epithelial cells by affinity chromatography, we discovered an unanticipated interaction of NadA with heat shock protein (Hsp) 90, a molecular chaperone. The specific in vitro interaction of recombinant soluble NadA and Hsp90 was confirmed by co-immunoprecipitations, dot and far-Western blot. Intriguingly, ADP, but not ATP, was required for this association, and the Hsp90 inhibitor 17-AAG promoted complex formation. Hsp90 binding to an Escherichia coli strain used as carrier to express surface exposed NadA confirmed these results in live bacteria. We also examined RNA interference, plasmid-driven overexpression, addition of exogenous rHsp90 and 17-AAG inhibition in human epithelial cells to further elucidate the involvement of Hsp90 in NadA-mediated adhesion and invasion. Together, these data suggest an inverse correlation between the amount of host Hsp90 and the NadA adhesive/invasive phenotype. Confocal microscopy also demonstrated that meningococci interact with cellular Hsp90, a completely novel finding. Altogether our results show that variation of host Hsp90 expression or activity interferes with adhesive and invasive events driven by NadA.
ChemInform Abstract: PREPARATION AND REACTIONS OF THE LITHIO AND DILITHIO SALTS OF 2,3‐DIMETHYLQUINOXALINE (1976)

Abstract Dimethylchinoxalin (I) reagiert mit Lithiumdiisopropylamid (II) in Gemischen von Tetrahydrofuran (THF) und Hexamethylphosphorsäuretriamid (HMPT) je nach dem Verhältnis der Reaktionspartner zu Mono‐ und Dilithiumsalzen (III) oder (IV).
From Dataset Recycling to Multi-Property Extraction and Beyond (2020)

This paper investigates various Transformer architectures on the WikiReading Information Extraction and Machine Reading Comprehension dataset. The proposed dual-source model outperforms the current state-of-theart by a large margin.
Magnetic Assembly and Cross-Linking of Nanoparticles for Releasable Magnetic Microstructures (2015)

This article describes a versatile method to fabricate magnetic microstructures with complex two-dimensional geometric shapes using magnetically assembled iron oxide (Fe3O4) and cobalt ferrite (CoFe2O4) nanoparticles. Magnetic pole patterns are imprinted into magnetizable media, onto which magnetic nanoparticles are assembled from a colloidal suspension into defined shapes via the shaped magnetic field gradients. The kinetics of this assembly process are studied by evaluation of the microstructure features (e.g., line width and height) as a function of time, particle type, and volume fraction. After assembly, the iron oxide particles are cross-linked in situ and subsequently released by dissolving a sacrificial layer. The free-floating magnetic structures are shown to retain their patterned shape during manipulation with external magnetic fields.
Amorphous Hole‐Transporting Material based on 2,2′‐Bis‐substituted 1,1′‐Biphenyl Scaffold for Application in Perovskite Solar Cells (2017)

Perovskite solar cells are considered a promising technology for solar-energy conversion, with power conversion efficiencies currently exceeding 20 %. In most of the reported devices, Spiro-OMeTAD is used for positive-charge extraction and transport layer. Although a number of alternative hole-transporting materials with different aromatic or heteroaromatic fragments have already been synthesized, a cheap and well-performing hole-transporting material is still in high demand. In this work, a two-step synthesis of a carbazole-based hole-transporting material is presented. Synthesized compounds exhibited amorphous nature, good solubility and thermal stability. The perovskite solar cells employing the newly synthesized material generated a power conversion efficiency of 16.5 % which is slightly lower than that obtained with Spiro-OMeTAD (17.5 %). The low-cost synthesis and high performance makes our hole-transport material promising for applications in perovskite-based optoelectronic devices.
A giant linear Fresnel zone plate as a hard x-ray condenser (2004)

We present the design and test of a large aperture linear Fresnel zone plate (FZP) as a condensing lens for hard X-rays. The FZP is made of Si and is defined by electron beam lithography and chemical wet etching of <110> oriented silicon substrates. The central zone is 75 &mu;m wide, the outermost lines have a width of 0.35 &mu;m, and the structures have a height of 10 &mu;m. These parameters result in an optimal focusing distance of 9 m, a phase shift of &#960;, and a diffraction efficiency of about 30% at 7.3 keV. We have tested the FZP at the Anomalous Scattering Beamline (ID01) of the ESRF. The FZP was inserted in the vacuum chamber in the Optics Hutch at 38.5 m from the source and 9 m from the sample. We have studied the dependence of beam size and gain as a function of energy in the range from 7 to 8.5 keV. We found the optimum energy range as 7.2-7.4 keV, where the focused beam width was 100 &mu;m and the experimental gain was 9.2, for an expected theoretical value of 9.6.
Selection of HIV-1 genotypes by cultivation in different primary cells (1999)

These results demonstrate that monocyte/macrophage and mixed MNC culture systems complement the standard lymphocyte culture in terms of the spectrum of genotypically different virus variants obtained in vitro.