gebhart/patrepeval huggingface dataset:
AN ATROPINE‐LIKE INHIBITORY EFFECT OF DMPP ON RAT ISOLATED URINARY BLADDER (1986)

DMPP inhibits the nerve-mediated contractions of the rat isolated bladder, its effect being greater in preparations from newborn (2 day old) than adult animals. This effect of DMPP was unaffected by hexamethonium. In preparations from adult animals the effect of DMPP increased with frequency of stimulation and was fully prevented by the presence of atropine. In bladders from newborn rats low concentrations of furthrethonium (FHR) (10 nM) activated a series of rhythmic contractions which were unaffected by tetrodotoxin and abolished by DMPP through an hexamethonium-insensitive action. On the other hand DMPP did not affect rhythmic contractions produced by a low concentration of eledoisin (60 nM). In bladders from adult rats FHR (10 microM) and KCI (30 mM) produced contractures of comparable magnitude. DMPP inhibited, in concentration-related manner the FHR-induced tonic contraction but had little effect on that produced by KCI. These findings indicate that in the rat bladder, DMPP antagonizes selectivity cholinergically-mediated contractions through a mechanism which is unaffected by hexamethonium or tetrodotoxin. An "atropine-like' activity of DMPP should be considered.
High-flux nanofiltration membranes tailored by bio-inspired co-deposition of hydrophilic g-C3N4 nanosheets for enhanced selectivity towards organics and salts (2019)

NF membranes functionalized through bio-deposition of g-C<sub>3</sub>N<sub>4</sub> nanosheets have enhanced water permeability, dye retention and salt transmission, showing great potential for sustainable treatment of highly saline textile wastewater.
Surgical Versus Nonsurgical Management of Rotator Cuff Tears (2015)

Background: Rotator cuff tears are a common shoulder disorder resulting in significant disability to patients and financial burden on the health care system. While both surgical and nonsurgical management are accepted treatment options, there is a paucity of data to support a treatment algorithm for care providers. Defining variables to guide treatment allocation may be important for patient education and counseling, as well as to deliver the most efficient care plan at the time of presentation. Purpose: To identify independent variables at the time of initial clinical presentation that are associated with preferred allocation to surgical versus nonsurgical management for patients with known full-thickness rotator cuff tears. Study Design: Case control study; Level of evidence, 3. Methods: A total of 196 consecutive adult patients with known full-thickness rotator cuff tears were enrolled into a prospective cohort study. Robust data were collected for each subject at baseline, including age, sex, body mass index (BMI), shoulder activity score, smoking status, size of cuff tear, duration of symptoms, functional comorbidity index, the American Shoulder and Elbow Surgeons (ASES) score, the Western Ontario Rotator Cuff index (WORC), and the Veterans Rand 12-Item Health Survey (VR-12). Logistic regression was performed to identify variables associated with treatment allocation, and the corresponding odds ratios were calculated. Results: Of the 196 patients enrolled, 112 underwent surgical intervention and 84 nonoperative management. With covariates controlled for, significant baseline patient characteristics predictive of eventual allocation to surgical treatment included younger age, lower BMI, and durations of symptoms less than 1 year. Increasing age, higher BMI, and duration of symptoms longer than 1 year were predictive of nonsurgical treatment. Factors that were not associated with treatment allocation included sex, tear size, functional comorbidity score, or any of the patient-derived outcome scores at presentation (ASES, WORC, VR-12, shoulder activity score). Conclusion: Patient demographics at the time of initial presentation for a symptomatic rotator cuff tear are more predictive of treatment allocation to a surgical or nonoperative approach than the patient-derived outcome scores for activity level and shoulder disability. Further study is warranted to help define appropriate indications for treatment allocation in patients with rotator cuff tears.
Hot-Lot Equivalent of Publishing—The Immersion Special Section (2004)

The <i>Journal of Micro/Nanopatterning, Materials, and Metrology</i> (JM3) publishes peer-reviewed papers on the core enabling technologies that address the patterning needs of the electronics industry.
Independent evaluation of a simple clinical prediction rule to identify right ventricular dysfunction in patients with shortness of breath (2015)

Abstract Background Many patients have unexplained persistent dyspnea after negative computed tomographic pulmonary angiography (CTPA). We hypothesized that many of these patients have isolated right ventricular (RV) dysfunction from treatable causes. We previously derived a clinical decision rule (CDR) for predicting RV dysfunction consisting of persistent dyspnea and normal CTPA, finding that 53% of CDR-positive patients had isolated RV dysfunction. Our goal is to validate this previously derived CDR by measuring the prevalence of RV dysfunction and outcomes in dyspneic emergency department patients. Methods A secondary analysis of a prospective observational multicenter study that enrolled patients presenting with suspected PE was performed. We included patients with persistent dyspnea, a nonsignificant CTPA, and formal echo performed. Right ventricular dysfunction was defined as RV hypokinesis and/or dilation with or without moderate to severe tricuspid regurgitation. Results A total of 7940 patients were enrolled. Two thousand six hundred sixteen patients were analyzed after excluding patients without persistent dyspnea and those with a significant finding on CTPA. One hundred ninety eight patients had echocardiography performed as standard care. Of those, 19% (95% confidence interval [CI], 14%-25%) and 33% (95% CI, 25%-42%) exhibited RV dysfunction and isolated RV dysfunction, respectively. Patients with isolated RV dysfunction or overload were more likely than those without RV dysfunction to have a return visit to the emergency department within 45 days for the same complaint (39% vs 18%; 95% CI of the difference, 4%-38%). Conclusion This simple clinical prediction rule predicted a 33% prevalence of isolated RV dysfunction or overload. Patients with isolated RV dysfunction had higher recidivism rates and a trend toward worse outcomes.
Universal Design for Quality of Life Technologies (2012)

Engineers and other designers commonly use specifications to frame a project's objectives and constraints. These are supplemented by standards, codes, and regulations to create the design package. However, typical design practices often inadvertently ignore the usefulness of the product, environment or information system by people for whom the product would benefit. Consequently, an early design does not work and requires additional iterations and phases of redesign. This drives up the design costs, delays the process, or by tradeoff, prevents individuals with various types of abilities and disabilities to use the design. The universal design approach offers an efficient cost-effective method to expand the population of potential consumers of a product design. Quality of life technologies demand designs that consider populations that are often missed. This paper defines the need for and characteristics of good universal design with illustrations of successful universal product design as well as erred designs that neglected significant populations of potential product users. By definition, quality of life technologies are inclusive, such as aging populations who function with impairments in vision, hearing, and motor abilities. Executing universal design strategies create more successful outcomes.
Dual-VT SRAM cells with full-swing single-ended bit line sensing for high-performance on-chip cache in 0.13 μm technology generation (2000)

Comparisons among different dual-VT design choices for a large on-chip cache with single-ended sensing show that the design using a dual-VT cell and low-VT peripheral circuits is the best, and provides 10% performance gain with 1.2x larger active leakage power, and 1.6% larger cell area compared to the best design using high-VT cells.
Nanosynthesis of Si-Ge-Sn Semiconductors and Devices via Purpose-built Hydride Compounds (2008)

We describe new routes to the growth of Ge and Sn-containing semiconductors on Si(100). For modest Sn concentrations GeSn alloys are expected to be direct-gap materials and this property can be exploited to develop band-to-band devices. The ternary GeSiSn system eliminates one of the major limitations of SiGe/Si by decoupling strain and bandgap. This may lead to new families of devices including quantum cascade lasers and high-efficiency solar cells based on hybrid group IV/III-V designs. The latest advances in low-temperature CVD of SiGe/Si, Ge/Si, GeSn/Si, GeSiSn/GeSn/Si and GeSiSn/Ge/Si materials are described and key developments leading to practical device fabrication are emphasized. This includes selective growth via novel epitaxy and practical doping protocols via designer molecular sources to achieve carrier concentrations n, p &gt; 1019 cm-3 for which alloy scattering to the electron and hole mobilities is very small. As an example of a GeSn/GeSiSn prototype device the fabrication of a simple photoconductor at 1.55 μm is presented.
Dynamic RF Combining for Multi-Antenna Ambient Energy Harvesting (2021)

Ambient radio frequency (RF) energy harvesting (EH) technology is key to realize self-sustainable, always-on, low-power, massive Internet of Things networks. Typically, rigid (non-adaptable to channel fluctuations) multi-antenna receive architectures are proposed to support reliable EH operation. Herein, we introduce a dynamic RF combining architecture for ambient RF EH use cases, and exemplify the attainable performance gains via three simple phase shifts’ exploration mechanisms, namely, brute force (BF), sequential testing (ST) and codebook based (CB). Among the proposed mechanisms, BF demands the highest power consumption, while CB requires the highest-resolution phase shifters, thus tipping the scales in favor of ST. Finally, we show that the performance gains of ST over a rigid RF combining scheme increase with the number of receive antennas and energy transmitters’ deployment density.
Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV (2022)

People living with HIV (PLH) have significantly higher rates of cognitive impairment (CI) and major depressive disorder (MDD) versus the general population. The enzyme neutral sphingomyelinase 2 (nSMase2) is involved in the biogenesis of ceramide and extracellular vesicles (EVs), both of which are dysregulated in PLH, CI, and MDD. Here we evaluated EcoHIV-infected mice for behavioral abnormalities relevant to depression and cognition deficits, and assessed the behavioral and biochemical effects of nSMase2 inhibition. Mice were infected with EcoHIV and daily treatment with either vehicle or the nSMase2 inhibitor (R)-(1-(3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl)pyrrolidin-3-yl)-carbamate (PDDC) began 3 weeks post-infection. After 2 weeks of treatment, mice were subjected to behavior tests. EcoHIV-infected mice exhibited behavioral abnormalities relevant to MDD and CI that were reversed by PDDC treatment. EcoHIV infection significantly increased cortical brain nSMase2 activity, resulting in trend changes in sphingomyelin and ceramide levels that were normalized by PDDC treatment. EcoHIV-infected mice also exhibited increased levels of brain-derived EVs and altered microRNA cargo, including miR-183-5p, miR-200c-3p, miR-200b-3p, and miR-429-3p, known to be associated with MDD and CI; all were normalized by PDDC. In conclusion, inhibition of nSMase2 represents a possible new therapeutic strategy for the treatment of HIV-associated CI and MDD.
Amphiphilic Biaryl Monophosphine Ligands by Regioselective Sulfonation (2021)

Amphiphilic ligands are valued for their ability to facilitate organometallic reactions in the presence of water. The regioselective sulfonation of a series of commercially available biaryl monophosphines to generate amphiphilic ligands is presented. In this one-step protocol, the temperature and addition of fuming sulfuric acid were carefully controlled to arrive at sulfonated biaryl monophosphine ligands in high yields with >95% regioselectivity without the need for chromatographic purification.
The light-induced effect of a-Si films and solar cells fabricated by the super chamber (1987)

The light‐induced effect of a‐Si films and solar cells fabricated by the super chamber (separated UHV reaction chamber) was systematically studied. It was confirmed that the reduction of impurities reduces the light‐induced effect in the range of 1018 cm−3 for oxygen. Furthermore, in the low impurity region, we found that other factors also have an influence on the light‐induced effect. In the low impurity region, the light‐induced degradations in a‐Si films and a‐Si solar cells were found to be reduced by reducing the SiH2 bond density. These results are effective for both the prevention of the light‐induced effect and the improvement of the conversion efficiency. As for cell structure, by using an n‐SiN/p‐SiC structure at the n/p junction in tandem solar cells, we obtained stable photovoltaic characteristics after light exposure for several hundred hours.
Accounting for the influence of salt water in the physics required for processing underwater UXO EMI signals (2018)

Processing electromagnetic induction signals from subsurface targets, for purposes of discrimination, requires accurate physical models. To date, successful approaches for on-land cases have entailed advanced modeling of responses by the targets themselves, with quite adequate treatment of instruments as well. Responses from the environment were typically slight and/or were treated very simply. When objects are immersed in saline solutions, however, more sophisticated modeling of the diffusive EMI physics in the environment is required. One needs to account for the response of the environment itself as well as the environment’s frequency and time-dependent effects on both primary and secondary fields, from sensors and targets, respectively. Here we explicate the requisite physics and identify its effects quantitatively via analytical, numerical, and experimental investigations. Results provide a path for addressing the quandaries posed by previous underwater measurements and indicate how the environmental physics may be included in more successful processing.
Prolactin-Releasing Activity of Dermorphin, a New Synthetic Potent Opiate-Like Peptide, in Normal Human Subjects* (1983)

Dermorphins (D) are heptapeptides (H-Tyr-D-Ala-Phe-Gly-Tyr-X-Ser-NH2; X, Pro or Hyp) with powerful central and peripheral opiate-like activity, originally isolated from the skin of South American frogs. To study the effect of a synthetic D on PRL secretion in man, either D (5.5 micrograms/kg . min for 30 min) or D-placebo (0.9% saline) infusion over 30 min was administered iv in random sequence to 11 volunteers (6 women and 5 men). In all the subjects, D induced a significant increase in the levels of PRL, more consistently in women than in men. To investigate whether the increase in PRL was due to the opiate agonist properties of D, the study was repeated in the same subjects during naloxone infusion. The PRL response to D was completely suppressed, suggesting that the peptide exerts its effect on PRL release via an opiate receptor stimulation of the mu-type. These data allow us to conclude that D may affect PRL release in humans; however, further investigation is necessary before any physiological significance might be attributed to D in man.
Synthesis and Structure of Nickel(II) Complex with Methyl-Substituted N2O2 Tetradentate Shiff Base (2021)

The crystal structure of the N,N′-(2,3-dimethylbutane-2,3-diylbis(3-methylsalicylideneiminate)nickel(II) complex was determined by means of single crystal X-ray analysis. The main characteristics of the complex obtained by 1H NMR, UV-VIS, and IR spectroscopy and voltammetry are presented.
Inhibition of protein kinase C prevents asbestos-induced c-fos and c-jun proto-oncogene expression in mesothelial cells. (1997)

Asbestos and the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), increase c-fos and c-jun mRNA levels and AP-1 DNA binding activity in rat pleural mesothelial (RPM) cells, a target cell of asbestos-induced mesotheliomas (N. H. Heintz et al., Proc. Natl. Acad. Sci. USA, 90: 3299-3303, 1993). Because protein kinase C (PKC) is the intracellular receptor of phorbol ester tumor promoters and asbestos is a putative tumor promoter in the respiratory tract, we hypothesized that PKC might play a critical role in asbestos-induced cell signaling pathways associated with regulation of proto-oncogenes. Using a panel of PKC antibodies, we identified PKC alpha as the major PKC isozyme in RPM cells. We then pretreated cells with phorbol ester dibutyrate to down-modulate PKC or with calphostin C, a specific PKC inhibitor, to determine if depletion of PKC alpha could block asbestos-induced c-fos/c-jun expression. Quantitation of Northern blots showed that fiber-associated c-fos/c-jun mRNA levels were significantly lower either after PKC alpha down-modulation or pretreatment with calphostin C. In addition, to determine whether tyrosine kinases also were involved in proto-oncogene activation by asbestos, tyrphostin AG82 or herbimycin A was added to RPM cells before exposure to asbestos. These inhibitors decreased crocidolite-induced c-fos but not c-jun levels, suggesting that tyrosine kinases have different regulatory roles in asbestos-induced c-fos versus c-jun signaling pathways. The ability to block induction of asbestos-induced proto-oncogene expression using pharmacological intervention may be important in prevention and treatment of asbestos-induced proliferative diseases including lung cancers, mesothelioma, and pulmonary fibrosis.
Noninvasive measurement of rate of left ventricular relaxation by Doppler echocardiography. Validation with simultaneous cardiac catheterization. (1993)

The descending limb of the Doppler-derived mitral regurgitation velocity signal can be used as a semiquantitative estimate of the rate of ventricular relaxation. This method requires knowledge of left atrial pressure and may not be sufficiently accurate for detecting small changes in the rate of relaxation on a beat-to-beat basis.
An Allogeneic Foundational Microorganism Relocate (2021)

Allogeneic immature microorganism transplantation includes moving the undifferentiated cells from a sound individual (the contributor) to the patient's body after extreme focus chemotherapy or radiation. The gave undeveloped cells can emerge out of either a related or a disconnected giver. Prior to an allogeneic undifferentiated organism transplantation, the patient gets a molding routine of chemotherapy and, now and again, radiation treatment. This molding therapy is given to annihilate any leftover malignancy cells in the body. This debilitates the patient's resistant framework to assist with holding the body back from dismissing the gave cells after the transfer. It additionally permits the giver cells to travel through the circulation system deep down marrow, where the benefactor cells will start to develop and deliver fresh blood cells, including red platelets, platelets and white platelets. This interaction is designated engraftment.
Data from Next Generation Sequencing of Prostate Cancer from a Patient Identifies a Deficiency of Methylthioadenosine Phosphorylase, an Exploitable Tumor Target (2023)

&lt;div&gt;Abstract&lt;p&gt;Castrate-resistant prostate cancer (CRPC) and neuroendocrine carcinoma of the prostate are invariably fatal diseases for which only palliative therapies exist. As part of a prostate tumor sequencing program, a patient tumor was analyzed using Illumina genome sequencing and a matched renal capsule tumor xenograft was generated. Both tumor and xenograft had a homozygous 9p21 deletion spanning the &lt;i&gt;MTAP&lt;/i&gt;, &lt;i&gt;CDKN2&lt;/i&gt;, and &lt;i&gt;ARF&lt;/i&gt; genes. It is rare for this deletion to occur in primary prostate tumors, yet approximately 10% express decreased levels of methylthioadenosine phosphorylase (MTAP) mRNA. Decreased &lt;i&gt;MTAP&lt;/i&gt; expression is a prognosticator for poor outcome. Moreover, it seems that this deletion is more common in CRPC than in primary prostate cancer. We show for the first time that treatment with methylthioadenosine and high dose 6-thioguanine causes marked inhibition of a patient-derived neuroendocrine xenograft growth while protecting the host from 6-thioguanine toxicity. This therapeutic approach can be applied to other MTAP-deficient human cancers as deletion or hypermethylation of the &lt;i&gt;MTAP&lt;/i&gt; gene occurs in a broad spectrum of tumors at high frequency. The combination of genome sequencing and patient-derived xenografts can identify candidate therapeutic agents and evaluate them for personalized oncology. &lt;i&gt;Mol Cancer Ther; 11(3); 775–83. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Flexibility of Interdomain Contacts Revealed by Topological Isomers of Bivalent Consolidated Ligands to the Dual Src Homology Domain SH(32) of Abelson, (1999)

Src homology (SH)2 and SH3 domains are found in a variety of proteins involved in the control of cellular signaling and architecture. The possible interrelationships between domains are not easily investigated, even though several cases of multiple domain-containing constructs have been studied structurally. As a complement to direct structural methods, we have developed consolidated ligands and tested their binding to the Abl SH(32) complex. Consolidated ligands combine in the same molecule peptide sequences recognized by SH2 and SH3 domains, i.e., Pro-Val-pTyr-Glu-Asn-Val and Pro-Pro-Ala-Tyr-Pro-Pro-Pro-Pro-Val-Pro, respectively; these are joined by oligoglycyl linkers. Four types of ligands were chemically synthesized, representing all the possible relative orientations of ligands. Their affinities were found to vary with binding portion topologies and linker lengths. Two of these types were shown to bind to both SH2 and SH3 dual domains with high affinities and specificities, showing increases of one order of magnitude, as compared to the most strongly bound monovalent equivalent. These results suggest that the relative orientation of SH2 and SH3 in Abl SH(32) is not fixed, and this synthetic approach may be generally useful for determining the structures of ligated complexes and for developing reagents with high affinities and specificities.