gebhart/patrepeval huggingface dataset:
Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits (2019)

Podocytes are known to express various complement factors including complement factor H (CFH) and to promote the removal of both subendothelial and subepithelial immune complex (IC) deposits. Using podocyte-selective injury model NEP25 mice and an IgG3-producing hybridoma clone 2B11.3 established by MRL/lpr mice, the present study investigated the role of podocyte complement regulation in only subendothelial IC deposition. In immunotoxin (LMB2) induced fatal podocyte injury (NEP25/LMB2) at day 12, glomerular CFH and C3a receptor (C3aR) expression was decreased as compared with NEP25/vehicle mice. In contrast, in sublytic podocyte injury 5 days after LMB2, glomerular CFH and C3aR expression was increased as compared with NEP25/vehicle mice. Intra-abdominal injection of 2B11.3 hybridoma to NEP25 mice (NEP25/hybridoma) caused IC deposition limited to the subendothelial area associated with unaltered CFH expression. NEP25/hybridoma mice with sublytic podocyte injury (NEP25/hybridoma/LMB2) resulted in increased glomerular CFH expression (1.7-fold) accompanied by decreased subendothelial IC deposition, as compared with NEP25/hybridoma. Immunostaining revealed that CFH was dominantly expressed in podocytes of NEP25/hybridoma/LMB2. In addition, puromycin-induced sublytic podocyte injury promoted CFH expression in immortalized mouse podocytes in vitro. These results suggest that in response to sublytic levels of injury, podocyte induced CFH expression locally and clearance of subendothelial IC deposits.
A Holistic Framework for Addressing the World Using Machine Learning (2018)

Millions of people are disconnected from basic services due to lack of adequate addressing. We propose an automatic generative algorithm to create street addresses from satellite imagery. Our addressing scheme is coherent with the street topology, linear and hierarchical to follow human perception, and universal to be used as a unified geocoding system. Our algorithm starts with extracting road segments using deep learning and partitions the road network into regions. Then regions, streets, and address cells are named using proximity computations. We also extend our addressing scheme to cover inaccessible areas, to be flexible for changes, and to lead as a pioneer for a unified geodatabase.
A Novel Methodology to Characterize the Thermal Behavior of Automotive Seats (2021)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;An automobile seat’s thermal performance can be challenging to quantify since it requires comprehensive human subject testing. Seat manufacturers must rely on subjective ratings to understand how the construction of a seat and its underlying heating and cooling technology may compare to other seats. Other factors may influence seat ratings published by global marketing information services companies (e.g., JD Power and Associates). In particular, occupants may be biased by the vehicle class in which a seat is installed and by how much the contribution of a specific vehicle’s HVAC system performance affects the perception of seat thermal comfort. Therefore, there is a need for an objective testing methodology that does not rely on human participants but is still capable of producing a thermal performance rating in terms of established thermal comfort scales.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;This paper describes a methodology that uses &lt;i&gt;in situ&lt;/i&gt; seat testing in a fixed temperature environment to derive the seat’s thermal characteristics. This characterization can subsequently be input to a human thermal physiology model to simulate thermal perception for a scenario of interest (e.g., a transient heat-up or cool-down), which may differ considerably from the original test environment. The test procedure involves placing a heated test device onto a seat and measuring the heat flux and temperature response at its surface. The test conditions are subsequently reproduced within a thermal model. The effective seat properties and heating characteristics are derived by matching the simulated thermal response with the measured response captured in the test data through a numerical optimizer. The study described in this paper includes a detailed description of the test protocol, the thermal model of the seat, the numerical optimization procedure used to derive its effective thermal properties, and a quantitative comparison of the simulated seat characterization results with measurements. Note that human thermal perception predictions are outside the scope of this paper but may be reported in future work.&lt;/div&gt;&lt;/div&gt;
Experimental and Analytical Approaches for Improving the Resolution of Randomly Barcoded Transposon Insertion Sequencing (RB-TnSeq) Studies (2022)

Randomly barcoded transposon insertion sequencing (RB-TnSeq) is an efficient, multiplexed method to determine microbial gene function during growth under a selection condition of interest. This technique applies to growth, tolerance, and persistence studies in a variety of hosts, but the wealth of data generated can complicate the identification of the most critical gene targets. Experimental and analytical methods for improving the resolution of RB-TnSeq are proposed, using <i>Pseudomonas putida</i> KT2440 as an example organism. Several key parameters, such as baseline media selection, substantially influence the determination of gene fitness. We also present options to increase statistical confidence in gene fitness, including increasing the number of biological replicates and passaging the baseline culture in parallel with selection conditions. These considerations provide practitioners with several options to identify genes of importance in TnSeq data sets, thereby streamlining metabolic characterization.
Insect-model Based Microrobot (2005)

It should be understood that a robot is not a simple automatic machine, but instead has a certain level of intelligence. Many kinds of intelligent robots have been developed in our laboratory during the past 15 years. These robots perform many kinds of activities such as the cup and ball game, top-spinning, walking on stilts, etc. These robots appear to be intelligent, but are they really and truly intelligent? One school of thought is that these robots are no more than simple automatic machines which are controlled by a computer with sophisticated programs. If this is true, then what is actual robot intelligence? We have attempted to construct a new robotics—insect-model-based microrobotics—in order to get a new concept of robot intelligence.
Missing data interpolation by using local-global neural networks (2002)

In this paper a new connectionist model is applied to missing data interpolation. This proposed architecture is trained by a scheme based on partition of the function domain, approximating the generator function by a set of very simple supporting functions. This method showed a very interesting ability concerning interpolation. Both, controlled numerical experiments and a real data missing data application for an electricity load series, are presented.
Scintillators having the K<sub>2</sub>PtCl<sub>6</sub> crystal structure (2023)

According to one embodiment, a scintillator includes a host material having the chemical formula: A&lt;sub&gt;2&lt;/sub&gt;BX&lt;sub&gt;6&lt;/sub&gt;, where A includes a monovalent ion, B includes a tetravalent ion, and X includes a halide ion.
Supplementary Figure 1 from Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth (2023)

Supplementary Figure 1 from Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth
Preparation of ( E )‐(2‐Iodovinyl)Benzene from Benzyl Bromide and Diiodomethane (2010)

Abstract Sodium bis(trimethylsilyl)amide Benzyl bromide 1,8‐Diazbicyclo[5.4.0]undec‐7‐ene (E)‐(2‐Iodovinyl)benzene
Rapid and sensitive detection of Candida mannan related to the immune system with a plasmonic sensor chip (2023)

Abstract To establish a rapid evaluation method for Candida mannan in the saliva, which is a marker molecule of immunity, we develop a fluorescent immunosensor enhanced with grating-coupled surface plasmon resonance using a plasmonic chip i.e., a metal-coated substrate with a wavelength-sized periodic structure. A two-dimensional hole-array chip with two kinds of pitches of 495 nm × 475 nm is used for fluorescence enhancement. The capture antibody is immobilized to the aminated chip surface via a crosslinker with succinimide at both ends, and a stable capture interface is constructed by covalent bonding. Finally, Candida mannan in the standard solution is measured up to 0.1 ng ml −1 . Furthermore, in saliva samples, Candida mannan is quantitatively detected between 0.05 and 0.25 ng ml −1 , and the highly sensitive detection with the Candida mannan assay system is indicated.
Effect of TiCl/sub 4/ pre-treatment in PECVD-Ti process for sub-0.2 μm metal bit line contacts (2002)

The effect of the initial steps in PECVD-Ti process is investigated for the optimization of TiSi/sub x/ formation. A remarkable difference in TiSi/sub x/ formation is observed between pre-plasma and pre-TiCl/sub 4/ treatment in which the initial steps start with H/sub 2/ gas with plasma and TiCl/sub 4/ gas without plasma. TiCl/sub 4/ pre-treatment in the PECVD-Ti process is compared with H/sub 2/ plasma pre-treatment especially for low aspect ratio contacts. PECVD-Ti films with H/sub 2/ plasma pre-treatment results in accumulation of Cl impurities at the interface between Si and TiSi/sub x/, and subsequently results in thinner TiSi/sub x/ and higher contact resistance. With the optimized TiCl/sub 4/ pretreatment, excellent electrical characteristics are obtained in sub-0.2 /spl mu/m bit line contacts.
High Quality GaN Grown from a Nanoporous GaN Template (2007)

10.1149/1.2792344
Dendritic cells origin (2002)

Les cellules dendritiques (CD) sont des cellules presentatrices d'antigenes d'origine hematopoietique, specialisees dans l'interaction avec les lymphocytes T et capables d'initier des reponses T primaires. Plus heterogenes que leur decouverte initiale ne le laissait supposer, les populations dendritiques semblent appartenir a differentes lignees hematopoietiques, et possederaient des specialisations fonctionnelles s'etendant bien au-dela de la simple presentation d'antigenes et activation des cellules T. Alors que dans des systemes de culture bien definies, des CD peuvent etre obtenues a partir de progeniteurs myeloides et lymphoides, les voies de differenciation dendritiques in vivo restent encore largement meconnues et ne semblent pas toujours correlees aux resultats obtenus in vitro. Des etudes de souris genetiquement modifiees ainsi que des experiences de transfert de progeniteurs hematopoietiques chez la souris sont en cours pour essayer de repondre a ces questions. Dans cette revue, nous presenterons les progres recents de la litterature dans ce domaine et discuterons l'influence de l'ontogenie des CD sur leur fonction biologique finale, ainsi que les perspectives therapeutiques qui en decoulent.
PSIV-8 Effect of Feeding Levucell SB® 10 Titan Advantage and YANG on Performance, Blood Parameters, and Fecal VFA of Nursery Pigs (2021)

Abstract A total of 496 weaned pigs (19 ± 1 d of age) were used in a 3-phase feeding program to evaluate effects of Levucell SB 10 Titan Advantage, a live yeast, Saccharomyces cerevisiae boulardii (LEV; Elanco) and a non-viable yeast product (YANG; Elanco) on performance, complete blood count (CBC), and fecal VFA of nursery pigs. Pigs were blocked by weaning BW and gender and allotted to 44 pens (11–12 pigs/pen) which was assigned to one of 4 dietary treatments (11 pens/treatment). The study was designed as 2 x 2 factorial with LEV and YANG. Pigs were fed to meet or exceed nutrient requirements (NRC, 2012). Blood (d 10 and 22) and fecal samples (d 22) were collected from one pig per pen for CBC and VFA analyses. During d 0–7, feeding LEV or YANG alone improved (P &amp;lt; 0.05) G:F by 20% and 12%, respectively. There was a tendency of LEV*YANG interaction (P &amp;lt; 0.10) where feeding LEV increased (P &amp;lt; 0.05) BW and ADG compared to the control (CON). During d 0–14, feeding YANG with LEV reduced (P &amp;lt; 0.05) BW, ADG, and G:F compared to feeding YANG or LEV alone. Pigs fed LEV had an improved G:F compared to pigs fed CON or YANG with LEV (P &amp;lt; 0.05). During d 21–42, there was a tendency (P &amp;lt; 0.10) for a LEV*YANG effect where pigs fed CON had a lower G:F compared to other treatments. Overall, feeding LEV alone increased (P &amp;lt; 0.01) G:F (2.4%) and numerically increased final BW (0.60 kg) compared to CON. LEV tended to increase blood lymphocytes (P = 0.11) and increased platelets and platelet hematocrit (P &amp;lt; 0.05) compared to CON. There were no differences in fecal VFA measures. The results of this study indicate that feeding LEV increased G:F of nursery pigs.
A novel circuital model for power electronic transformer: sizing and simulation (2014)

The rail traffic in Europe is increasing in frequency. As a result of this, all the countries are updating their power supply system involving the use of high-power static converters. Moreover, the high required power implies the use of medium voltage (MV) supply chains (i.e. 15-25 kV) while the traction drives are operated at voltages of some kV. In order to adapt the two voltage levels, an on board transformer is typically used. Anyway, this transformer is characterized by high size and weight and limits the performances of the vehicle. A solution to this issue can be represented by the use of a power electronic transformer (PET) that is constituted by a double stage converter with an interposed high frequency transformer. The use of a high frequency transformer instead of the traditional at industrial frequency allows the reduction of size and weight with consequent advantages for vehicle performances. The paper presents a focus on circuital model, design and dimensioning of a PET. In particular, a topology of the converters and the relative control strategy are proposed. Moreover, the problem of core sizing is analysed and some guidelines are given. Finally, for chosen values of power and switching frequency, the sizing is executed and results of numerical simulations are given.
Microscale Dielectric Barrier Discharge Plasma Actuators: Performance Characterization and Numerical Comparison (2012)

Dielectric barrier discharge (DBD) plasma devices have been designed and manufactured with microscale dimensions utilizing semiconductor fabrication techniques. Particle image velocimetry (PIV) measurements indicate induced wall jet velocities up to 2.0 m/s. Direct force measurements using a torsional balance indicate thrust values up to 3 mN/m at 5 kVpp and 1 kHz and consume an average power of 15 W/m. The measured thrust data is applied in a numerical model to compare simulated velocity flow fields with experimental PIV data. The model shows good agreement with experimental data for the velocity and wall jet thickness for macro device geometries, but inaccurately predicts the downstream velocity decay. Microscale devices demonstrated equivalent ‘thrust effectiveness’ to macroscale actuators, but with a 31% improvement in mechanical-to-electrical energy conversion efficiency. The microscale DBD actuators occupy an order of magnitude reduction in device footprint and mass, and potentially enable large arrays for distributed flow control applications.
ChemInform Abstract: TETRACYCLIC DITERPENOIDS BY INTRAMOLECULAR C‐ALKYLATION OF ΓΔ‐UNSATURATED DIAZO KETONES (1979)

Abstract Aus der Vinylverbindung (I) erhält man über eine Oxidation zu (IIa) das Diazoketon (IIb), das zum Carbinol (IIc) hydrolysiert und zu den beiden Ketonen (III) und (IV) cyclisiert werden kann.
Development of a New Generation of 4-Aminoquinoline Antimalarial Compounds Using Predictive Pharmacokinetic and Toxicology Models (2010)

Among the known antimalarial drugs, chloroquine (CQ) and other 4-aminoquinolines have shown high potency and good bioavailability. Yet complications associated with drug resistance necessitate the discovery of effective new antimalarial agents. ADMET prediction studies were employed to evaluate a library of new molecules based on the 4-aminoquinolone-related structure of CQ. Extensive in vitro screening and in vivo pharmacokinetic studies in mice helped to identify two lead molecules, 18 and 4, with promising in vitro therapeutic efficacy, improved ADMET properties, low risk for drug-drug interactions, and desirable pharmacokinetic profiles. Both 18 and 4 are highly potent antimalarial compounds, with IC(50) values of 5.6 and 17.3 nM, respectively, against the W2 (CQ-resistant) strain of Plasmodium falciparum (for CQ, IC(50) = 382 nM). When tested in mice, these compounds were found to have biological half-lives and plasma exposure values similar to or higher than those of CQ; they are therefore desirable candidates to pursue in future clinical trials.
Rate-adaptive multimedia multicasting over IEEE 802.11 wireless LANs (2006)

Multimedia services are a major application for IEEE 802.11 WLANs but the current standard does not utilize any rate adaptation technique for multicasting. SARM (SNR- based auto rate for multicast) is a new rate adaptation mechanism for multicasting multimedia content in IEEE 802.11 WLAN environments. Since there is no RTS/CTS or MAC ACK frame in multicast packet transmissions, SARM uses an auxiliary signaling method to obtain the channel quality for each mobile node. By adapting a transmission rate based on the SNR of the node experiencing the worst air-channel, SARM achieves the best quality of service for the prevailing conditions. This reduces the proportion of wireless channel resources assigned to multicasting, allowing more bandwidth for unicast flows.
Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients (2023)

ClinicalTrials.gov Identifier: NCT03443869; EudraCT: 2017-001055-30.
Contrasting the incorporation of glycerol into lipids caused by the presence of two isoforms of diacylglycerol kinase (605.20) (2014)

The mammalian isoforms of diacylglycerol kinase (DGK) include the epsilon isoform (DGKε) and the delta isoform (DGKδ). DGKε has specificity for substrates with an arachidonoyl group, while DGKδ shows no acyl chain specificity for the substrate, but it promotes fatty acid synthesis resulting in an increased fraction of lipids with shorter and less unsaturated acyl chains. We have compared the effects of knocking out each of these isoforms individually using SV40 transformed mouse embryo fibroblasts (MEFs). We compared wild‐type (WT) MEFs with those from knock‐out (KO) mice. We find that DGKδ‐KO MEFs have lower incorporation of 3 H‐glycerol into lipids compared with their WT counterparts. This is consistent with our recent demonstration (Biochemistry (2013) 52 , 7766) that the depletion of this DGK isoform results in less fatty acid synthesis. This change is not caused by a decreased expression of glycerol kinase in the KO cells. In contrast, the DGKε‐KO MEFs show greater incorporation of 3 H‐glycerol into lipids compared with their WT counterparts, with no change in the relative amounts of various lipids between the DGKε‐KO and WT MEFs. This result is explained by our observation that glycerol kinase is more highly expressed in the DGKε‐KO cells than in their WT counterparts.
Palladium‐Catalyzed Tandem Heck Reaction/CH Functionalization—Preparation of Spiro‐Indane‐Oxindoles (2008)

Tied up nicely: A novel tandem reaction involving an intramolecular Heck reaction with subsequent functionalization of an unactivated CH bond to generate spiro-fused indane-oxindoles is described (see scheme; PMB=p-methoxybenzyl).
Maximization of measurement sensitivity and reading range of passive RF sensors from complex impedance optimization (2017)

This paper reports a method to improve the performances of passive Radiofrequency sensors in terms of reading range and measurement sensitivity. More specifically the impedance profile of the sensing device that maximizes the measurement sensitivity and reading range is derived. This profile allows predicting the largest achievable reading range and the highest measurement sensitivity that can be achieved by a given sensor antenna. The proposed original method is illustrated through the design of a wireless and passive temperature sensor. Experimental results are reported for validation purposes.
Lens-coupled MeV x-radiography with transparent ceramic GLO scintillators (2021)

Lens-coupled X-ray computed tomography (X-ray CT) using a transparent scintillator imaged on a CCD camera obtains higher spatial resolution than the more commonly employed phosphor-enhanced amorphous silicon (A-Si) panels. A-Si panels are limited to resolution typically greater than ~200 microns, have a limited working life due to degradation with dose, and provide intrinsically low efficiency with thin (few hundred microns thick) phosphor coatings. Demanding applications such as imaging the interior of complex additively manufactured components require high throughput and high resolution, best achieved with a lens-coupled system. However, for large fields-of-view, very large area but thin transparent scintillators are required – a format difficult to fabricate with high light yield single crystals – therefore, glass scintillators with both modest X-ray interaction and light yield have been used for years. We have developed a new polycrystalline transparent ceramic scintillator, Gd0.3Lu1.6Eu0.1O3, or “GLO,” that offers excellent stopping power and light yield for improved contrast in sizes up to 14” x 14” plates, with thicknesses in the 2-10 mm range, and we are implementing it in systems to increase imaging throughput for 9 MeV Bremsstrahlung X-ray CT. CT imaging performance will be described.
Motivating Complex Dependence Structures in Data Mining: A Case Study with Anomaly Detection in Climate (2009)

While data mining aims to identify hidden knowledge from massive and high dimensional datasets, the importance of dependence structure among time, space, and between different variables is less emphasized. Analogous to the use of probability density functions in modeling individual variables, it is now possible to characterize the complete dependence space mathematically through the application of copulas. By adopting copulas, the multivariate joint probability distribution can be constructed without constraint to specific types of marginal distributions. Some common assumptions, like normality and independence between variables, can also be relieved. This study provides fundamental introduction and illustration of dependence structure, aimed at the potential applicability of copulas in general data mining. The case study in hydro-climatic anomaly detection shows that the frequency of multivariate anomalies is affected by the dependence level between variables. The appropriate multivariate thresholds can be determined through a copula-based approach.
Circulating Phospholipid Patterns in NAFLD Patients Associated with a Combination of Metabolic Risk Factors (2018)

Our extended lipidomic study presents a unique metabolic profile of circulating phospholipids associated with the presence of metabolic risk factors or the genetic background of NAFLD patients.
Conception automatisée d'un tag RFID UHF robuste (2009)

National audience