gebhart/patrepeval huggingface dataset:
Potent Benzimidazole Sulfonamide Protein Tyrosine Phosphatase 1B Inhibitors Containing the Heterocyclic ( S )-Isothiazolidinone Phosphotyrosine Mimetic (2006)

Potent nonpeptidic benzimidazole sulfonamide inhibitors of protein tyrosine phosphatase 1B (PTP1B) were derived from the optimization of a tripeptide containing the novel (S)-isothiazolidinone ((S)-IZD) phosphotyrosine (pTyr) mimetic. An X-ray cocrystal structure of inhibitor 46/PTP1B at 1.8 A resolution demonstrated that the benzimidazole sulfonamides form a bidentate H bond to Asp48 as designed, although the aryl group of the sulfonamide unexpectedly interacts intramolecularly in a pi-stacking manner with the benzimidazole. The ortho substitution to the (S)-IZD on the aryl ring afforded low nanomolar enzyme inhibitors of PTP1B that also displayed low caco-2 permeability and cellular activity in an insulin receptor (IR) phosphorylation assay and an Akt phosphorylation assay. The design, synthesis, and SAR of this novel series of benzimidazole sulfonamide containing (S)-IZD inhibitors of PTP1B are presented herein.
Improving adaptive feedback cancellation in hearing aids using an affine combination of filters (2016)

In adaptive feedback cancellation an adaptive filter is used to model the acoustic feedback path between the hearing aid loudspeaker and the microphone. An important parameter for adaptive filters is the step-size, providing a trade-off between fast convergence and low steady-state misalignment. In order to achieve both fast convergence as well as low steady-state misalignment, it has been proposed to use an affine combination scheme of two filters operating with different step-sizes. In this paper we apply such an affine combination scheme to the acoustic feedback cancellation problem in hearing aids. We show that for speech signals a time-domain affine combination scheme yields a biased solution. To reduce this bias we propose to use a partitioned-block frequency-domain affine combination scheme. Experimental results using measured acoustic feedback paths show that in terms of misalignment and added stable gain the proposed adaptive feedback cancellation system outperforms a system that only uses a single adaptive filter with either of the fixed step-sizes used for the affine combination scheme.
Photoelectrochemical Properties of Supramolecular Composite of Fullerene Nanoclusters and 9-Mesityl-10-carboxymethylacridinium Ion on SnO2 (2004)

[structure: see text] The photovoltaic cell composed of both fullerene nanoclusters and 9-mesityl-10-carboxymethylacridinium ion exhibits significant enhancement in the photoelectrochemical performance as well as broader photoresponse in the visible and near-infrared regions as compared with the reference system containing only each component.
Measurement of CP asymmetries in the decays B 0 → K *0 μ + μ − and B + → K + μ + μ − (2014)

The direct CP asymmetries of the decays B 0 K * 0 + -and B + K + + - are measured using pp collision data corresponding to an integrated luminosity of 3.0 fb -1 collected with the LHCb detector. The respective control modes B 0 J/K * 0 and B + J/K + are used to account for detection and production asymmetries. The measurements are made in several intervals of + -invariant mass squared, with the (1020) and charmonium resonance regions excluded. Under the hypothesis of zero CP asymmetry in the control modes, the average values of the asymmetries are
Downlink Base Station Cooperative Transmission Under Limited-Capacity Backhaul (2013)

Coordinated multi-point transmission (CoMP) joint processing (CoMP-JP) is a promising technique for supporting high spectral efficiency in future cellular systems. However, this technique requires high-capacity backhaul links for connecting multiple base stations (BSs), which leads to high deployment costs. CoMP coordinated beamforming (CoMP-CB) needs less backhaul capacity, but with lower maximal multiplexing gain. In this paper, we study downlink CoMP strategies with limited-capacity backhaul. We start by investigating the optimal interference-free transmission strategy under backhaul rate constraints, where only a part of the data is shared among the BSs. We then study soft and hard switching between the CoMP-JP and CoMP-CB modes. Finally, a closed-form semi-dynamic distributed hard switching scheme is proposed, which depends on the local large-scale channel gains of the users. Simulation results show that both the soft and hard mode switching transmission perform closely to the optimal strategy and outperform the single-mode CoMP transmission especially when the backhaul capacity is very limited.
Detection Probability of PRACH with Short Sequence Considering Carrier Frequency Offset for NR Radio Interface (2022)

This paper presents the miss-detection probability (MDP) of the Physical Random Access Channel (PRACH) with a short sequence for the New Radio radio interface considering carrier frequency offset(CFO)based on link-level simulations. The sequence and received timing of the PRACH are detected in the time domain based on the correlation between the received PRACH signal and the PRACH sequence candidates obtained using a matched filter in the frequency domain. This is followed by combining the correlations of the fast Fourier transform blocks that correspond to the repeated PRACH sequences in the time domain. Based on the PRACH MDP, we compare the combining method for the correlations of the repeated PRACH sequences in the in-phase/quadrature domains to that in the power domain. We also present the PRACH MDP for the subcarrier spacing (SCS) from 120 kHz to 960 kHz considering the CFO and show the effectiveness of a wide SCS in reducing the PRACH MDP.
Prostate Cancer Reshapes the Secreted and Extracellular Vesicle Urinary Proteomes (2023)

Urine is a complex biofluid that reflects both overall physiologic state and the state of the genitourinary tissues through which it passes. It contains both secreted proteins and proteins encapsulated in tissue-derived extracellular vesicles (EVs). To understand the population variability and clinical utility of urine, we quantified the secreted and EV proteomes from 190 men, including a subset with prostate cancer. We demonstrate that a simple protocol enriches prostatic proteins in urine. Secreted and EV proteins arise from different subcellular compartments. Urinary EVs are faithful surrogates of tissue proteomes, but secreted proteins in urine or cell line EVs are not. The urinary proteome is longitudinally stable over several years. It can accurately and non-invasively distinguish malignant from benign prostatic lesions, and can risk-stratify prostate tumors. This resource quantifies the complexity of the urinary proteome, and reveals the synergistic value of secreted and EV proteomes for translational and biomarker studies.
Production of Interleukin-6 by Folliculo-Stellate Cells of the Anterior Pituitary Gland in a Histiotypic Cell Aggregate Culture System (1989)

Reaggregate cell cultures of mouse or rat anterior pituitary were found to produce interleukin-6 (IL-6), a cytokine known for its multiple actions in the immune system. Studies on aggregates prepared from differentially enriched pituitary cell populations revealed the presence of folliculo-stellate (FS) cells to be essential for IL-6 production. Aggregates that contained only hormone-secreting, but no FS cells, failed to produce IL-6. Furthermore, the yield of IL-6 increased with increasing proportions of FS cells present in the aggregates. It is suggested that IL-6 participates in the local regulation of the secretory function of the hypophysis and may constitute a link between events in the immune system and those in the endocrine system.
Simulation Studies for Nonlinear-Transmission-Line Based Ultrafast Rise Times and Waveform Shaping for Pulsed-Power Applications (2008)

The generation of high-voltage electrical pulses with very fast rise times is important for several pulsed-power applications. Although several techniques and devices have been used to generate ultrashort rise-time pulses, most suffer from problems relating to reliability, lifetime, and power-handling capacity. Here, the concept of using nonlinear transmission lines is used for attaining ultrashort rise times and pulse sharpening. Numerical simulations are carried out using barium strontium titanate as the dielectric system. The concept is based on using the nonlinear voltage-dependent capacitance of the granular material. The presence of internal grains increases the breakdown strength and also provides for a nonlinear voltage-dependent capacitance that depends on the internal grain size. The output characteristics of transmission lines based on such nonlinear material are simulated. Our results clearly demonstrated rise-time shortening. The results were in agreement with some published experimental data.
Numerical investigation of interface region flows in mass spectrometers: neutral gas transport (2004)

The supersonic jet flows of neutral gas from atmospheric to near-vacuum conditions in the interface region of mass-spectrometer systems is investigated by continuum-based (fluid) numerical simulations. An enhanced understanding of the neutral gas transport is of paramount importance to fully understand flows in the interface region of mass spectrometers, for it is the neutral dynamics that governs and drives the ions from the high pressure ion source through the interface orifice towards the ion optics and detector subsystems. The key features and structure of the complex neutral gas flow are examined and the influence of large pressure differences imposed across the interface region, orifice geometry, and gas skimmer configuration used for flow control are assessed. The flow structure is shown to be that of a classical under-expanded free jet for 'skimmer-absent' cases and very good agreement between the numerical predictions and empirical and experimental values is demonstrated. For the 'skimmer-present' cases, the shock structure downstream of the orifice and skimmer is identified and fully described and its influences on the flow skimming and focusing processes are discussed.
Nearly instantaneous collision and interference detection using in-band full duplex (2017)

In wireless communication it is assumed that transmitting nodes are unable to detect collisions. However, using recent advances in in-band full duplex, a system can be developed where the self-transmitted signal is sufficiently canceled in order to detect ongoing collisions. Enabling concurrent transmission and collision detection can greatly improve wireless communication by enhancing throughput and decreasing delay and energy consumption. For this demo, we implemented a real-time collision and interference detection algorithm on the FPGA of a USRP. Inband full duplex is enabled using an electrical balance duplexer. A second USRP is used to generate interfering signals on demand.
Microwave Assisted Novel Efficient Pd-free Catalyst for Suzuki C-C Coupling Reaction (2019)

Suzuki cross-coupling reaction has developed one of the furthermost effectual approaches for the synthesis of biaryls or substituted aromatic moieties from aryl halides and arylboronic acids with a palladium-catalyst in the past two era&amp;rsquo;s. Herein, Pd-free layered double hydroxide containing nickel catalysts were prepared by co-precipitation method under ultrasonic irradiation and N2 atmosphere with different molar ratios of Ni: Mg: Al and coded as (1NiLDHs-Dr), (1.5NiLDHs-Dr) and (2NiLDHs-Dr). A series of reduced catalysts under 5%H2/N2 at different temperatures were coded as 1NiLDHs-R200, 1.5NiLDHs-R200 and 2NiLDHs-R200. As-synthesized 2NiLDHs-Dr was the superlative catalyst when coupling different aryl halides with different boronic acids derivatives. Deep investigation of all catalysts was done using different techniques such as inductively coupled plasma optical emission spectroscopy (ICP-OES), x-ray photoelectron spectroscopy (XPS), powder x-ray diffraction (XRD), thermogravimetric analyses (TGA), Fourier transfer infrared (FTIR), scanning electron microscope (SEM) connected with energy dispersive x-ray (EDX) and N2-physisorption at -196 ℃. The results attained verified that ɑ-Ni(OH)2 was fashioned for 2NiLDHs-Dr catalyst and the enclosure of nickel ions in the cationic sheet of layered structure were responsible for the fascinating catalytic efficacy rather than the basic nature of material. The Ni-containing LDHs catalysts encourage forthcoming studies in Pd-free catalyzed C-C coupling reactions.
Combined Partial Acid Hydrolysis and Electrospray Ionization-Mass Spectrometry for the Structural Determination of Oligosaccharides (2000)

A general oligosaccharide acid hydrolysis method, amenable to electrospray ionization mass spectrometry (ESI-MS), is described that allows for hydrolysis of glycosidic bonds for both hexose- and N-acetylhexosamine-containing oligosaccharides. The partial acid hydrolysis of oligosaccharides is obtained by using an acid-exchange resin as the acid catalyst. A ladder sequence of the glycan is produced in solution that is directly analyzed by ESI tandem mass spectrometry, employing both ion trap and Fourier transform ion cyclotron resonance mass spectrometers, to provide sequence and linkage information. Unlike traditional acid hydrolysis procedures, there is minimal degradation of monosaccharide residues or deacetylation of N-acetylhexosamines by employing this technique. It is further demonstrated that the stereochemistry of the released monosaccharides and the anomeric configuration within disaccharides is determined by direct derivatization of the hydrolysate with Zn(dien)-Cl2 followed by ESI-MS/MS.
Fast automatic algorithm for bifurcation detection in vascular CTA scans (2012)

Endovascular imaging aims at identifying vessels and their branches. Automatic vessel segmentation and bifurcation detection eases both clinical research and routine work. In this article a state of the art bifurcation detection algorithm is developed and applied on vascular computed tomography angiography (CTA) scans to mark the common iliac artery and its branches, the internal and external iliacs. In contrast to other methods our algorithm does not rely on a complete segmentation of a vessel in the 3D volume, but evaluates the cross-sections of the vessel slice by slice. Candidates for vessels are obtained by thresholding, following by 2D connected component labeling and prefiltering by size and position. The remaining candidates are connected in a squared distanced weighted graph. With Dijkstra algorithm the graph is traversed to get candidates for the arteries. We use another set of features considering length and shape of the paths to determine the best candidate and detect the bifurcation. The method was tested on 119 datasets acquired with different CT scanners and varying protocols. Both easy to evaluate datasets with high resolution and no apparent clinical diseases and difficult ones with low resolution, major calcifications, stents or poor contrast between the vessel and surrounding tissue were included. The presented results are promising, in 75.7% of the cases the bifurcation was labeled correctly, and in 82.7% the common artery and one of its branches were assigned correctly. The computation time was on average 0.49 s &plusmn; 0.28 s, close to human interaction time, which makes the algorithm applicable for time-critical applications.
Modelling of Proton Density Distribution in Active Nanopores of Fuel Cell Catalyst Layers (2016)

Proton density and mobility in porous electrodes determine the proton conductivity as well as the rates of interfacial electrochemical processes. In the case of polymer electrolyte fuel cells (PEFCs), the foremost practical objective is to design porous electrodes or catalyst layers with high performance at markedly reduced platinum loading. Achieving this objective demands an understanding of the impact of composition and porous structure as well as surface structure and charging properties of pore walls on the proton density distribution 1 . In the presented work, we consider simple pore geometries to study the concerted effects of ionomer structure and metal charging properties on proton density in nanopores. The approach employs Poisson-Nernst-Planck theory 2, 3 . The basic model system is a cylindrical pore confined by an ionomer shell. The core to consist of a solid metal rod and the gap space between the core and the ionomer shell is filled with water. The set of ordinary differential equations for proton density and reaction in these model structures is formulated and solved. Solutions are analysed by comparing potential and proton density distributions for varying pore geometries and charging properties at interfaces. The effectiveness factor of catalyst utilization is calculated to evaluate the electrocatalytic performance at the pore level 4, 5 . References [1] A.Weber et al., J. Electrochem. Soc. 161(12), (2014), F1254-F1299 [2] R.Coalson and M.Kurnikova, Biological membrane Ion channels, Chap 13, Springer, NewYork (2001) [3] K.Chan and M.Eikerling, J. Electrochem. Soc. 158(1), (2011), B18-B28. [4] K.Chan and M.Eikerling, J. Electrochem. Soc. 159(2), (2012), B155-B164 [5] A.Bonnefont, F.Argoul, and M.Z.Bazant, J. Electroanal. Chem., 500, 52, (2011
Abstract A98: Cancer-associated fibroblasts promote immunosuppression by inducing NOX2-expressing monocytic MDSCs in lung squamous cell carcinoma (2020)

Abstract Cancer-associated fibroblasts (CAFs) are activated fibroblasts that constitute the stromal component in the tumor microenvironment (TME). Although CAFs have been shown to promote tumor growth and mediate resistance to chemotherapy, their roles and potential mechanisms by which they may contribute to immune suppression in lung squamous cell carcinoma (LSCC) remain largely unexplored. Here, we identified a positive correlation between CAF and monocytic myeloid cell abundances in 501 primary LSCCs by mining the TCGA dataset. We further validated this finding in an independent cohort using imaging mass cytometry and found a significant spatial interaction between CAFs and monocytic myeloid cells in the TME. To delineate the interplay between CAFs and monocytic myeloid cells, we used chemotaxis assays to show that LSCC patient-derived CAFs promoted recruitment of CCR2+ monocytes via CCL2, which could be reversed by CCR2 inhibition. Using a three-dimensional culture system, we found that CAFs polarized monocytes to adopt a myeloid-derived suppressor cell (MDSC) phenotype characterized by robust suppression of autologous CD8+ T-cell proliferation and IFNγ production. To elucidate additional immunosuppressive mechanisms of CAF-educated MDSCs, we performed proteomic profiling and identified the NADPH oxidase 2 (NOX2) complex to be highly enriched in MDSCs. Pharmacologic inhibition of NOX2 activity in CAF-induced MDSCs restored CD8+ T-cell proliferation. Taken together, our study highlights a pivotal role of CAFs in regulating monocyte recruitment and differentiation and demonstrates that NOX2 inhibition abrogates the CAF-MDSC axis, illuminating a potential therapeutic path to reversing the CAF-mediated immunosuppressive microenvironment. Citation Format: Handan Xiang, Carlo Ramil, Josephine Hai, Chunsheng Zhang, Huijun Wang, Amanda A. Watkins, Roshi Afshar, Peter Georgiev, Xuelei Song, Dongyu Sun, Andrey Loboda, Yanlin Jia, Lily Y Moy, An Chi, Philip E. Brandish. Cancer-associated fibroblasts promote immunosuppression by inducing NOX2-expressing monocytic MDSCs in lung squamous cell carcinoma [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology and Immunotherapy; 2019 Nov 17-20; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2020;8(3 Suppl):Abstract nr A98.
Pharmacokinetics of Saruplase, a Recombinant Unglycosylated Human Single-Chain Urokinase-Type Plasminogen Activator and Its Effects on Fibrinolytic and Haemostatic Parameters in Healthy Male Subjects (1993)

Pharmacokinetics of two doses of the recombinant single-chain urokinase-type plasminogen activator (r-scu-PA) saruplase (40 and 20 mg) and its effect on fibrinolytic and haemostatic parameters were studied in six healthy male subjects using a randomized, double-blind, placebo-controlled, cross-over study. Special precautions were taken to prevent artefactual in vitro effects on fibrinolytic activity. The clearance of saruplase ranged from 310 to 862 ml/min and the apparent volume of distribution of the central compartment was about 8 1. Both doses of saruplase caused alpha 2-antiplasmin consumption, indicating some systemic fibrinolytic activation. However, the 20 mg dose caused no detectable fibrinogen breakdown and only a small increase in total fibrin/fibrinogen degradation products (TDP) (from 0.16 microgram/ml [range 0.14 to 0.19] to 0.78 microgram/ml [range 0.56 to 1.26]), while the 40 mg dose produce a fibrinogen breakdown to an average value of 44% (range 19 to 60%) and TDP increased from 0.12 microgram/ml (range 0.11-0.12) to 2.29 micrograms/ml (range 0.45 to 5.55). The breakdown of fibrinogen was related to the quantity of saruplase converted to active two-chain u-PA (tcu-PA) in vivo (6 to 22% conversion). There were no important effects of saruplase on overall blood coagulation (activated partial thromboplastin time) and platelet function (collagen induced platelet aggregation, urinary [2,3-dinor]-thromboxane B2 excretion and plasminogen activator inhibitor 1 [PAI-1] release from platelets). Saruplase is cleared rapidly from the plasma and a variable amount is converted to tcu-PA. This two-chain form of u-PA probably causes the dose-dependent systemic fibrinolytic activation.
An Algorithm to Generate Representations of System Identification Errors (2008)

An algorithm to generate representations of system identification (SI) errors, which enables systematic testing of the performance of system equalization techniques, is proposed. With this algorithm, the normalized projection misalignment (NPM) of the generated error representation can be chosen to suit the particular characteristics of the application under test. Additionally, the generated error representation can represent all the error vectors corresponding to different scaling factors in the estimates of the system impulse response (SIR), without influencing the signal‐to‐distortion ratio (SDR) of the equalized impulse response.