gebhart/patrepeval huggingface dataset:
Structure, magnetism, and Moessbauer spectrum of the five-coordinate complex chlorobis(N-methylbenzothiohydroxamato)iron(III) (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure, magnetism, and Moessbauer spectrum of the five-coordinate complex chlorobis(N-methylbenzothiohydroxamato)iron(III)Kevin J. Berry, Paul E. Clark, Keith S. Murray, Colin L. Raston, and Allan H. WhiteCite this: Inorg. Chem. 1983, 22, 26, 3928–3934Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/ic00168a021https://doi.org/10.1021/ic00168a021research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Table S2 from Delta-Like Ligand–Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer Prognosis (2023)

&lt;p&gt;Clinicopathological characteristics of DLL4/N1ICD risk groups (Institutional cohort)&lt;/p&gt;
A 2.7pJ/cycle 16MHz SoC with 4.3nW Power-Off ARM Cortex-M0+ Core in 28nm FD-SOI (2017)

International audience
[Experience with e new water soluble contrast medium for lumbar myelography (author's transl)]. (1976)

Meglumin-Iodrinat has been synthesized as the contrasting part of Myelografin by Schering AG. and tested for lumbar Myelography in animal experiments. The excellent neural and general compatibility justified a first clinical trial. 200 patients were examined, 100 each with following upright or lying down positions. There were no local symptoms, no signs of spinal or cerebral irritation. This is seen to be the main advantage compared with drugs used so far. Intensity of contrast corresponded with that of Conray 60 and Dimer X. The most common complaints like headache and nausea were interpreted as CSF hypotension and can be clearly reduced by lying down. Also the concentration of the contrastmedium diminishes more rapidly with the patient lying down.
Treatment of refractory aplastic anemia with recombinant human granulocyte-macrophage-colony-stimulating factor (1989)

Fifteen patients with refractory aplastic anemia or agranulocytosis received treatment with recombinant human granulocyte-macrophage-colony-stimulating factor (rhGM-CSF) in doses from 4 to 64 micrograms/kg/d by continuous intravenous (IV) infusion. Ten of 11 evaluable patients with aplastic anemia had substantial increments in granulocytes, monocytes, and eosinophils associated with myeloid and eosinophilic hyperplasia in the bone marrow. Patients with pretreatment granulocytes greater than 0.3 x 10(9)/L had greater increments in circulating myeloid cells than patients with more severe granulocytopenia. Only one patient had improvement in erythrocytes and platelets. Blood counts fell to baseline after rhGM-CSF treatment was discontinued. Doses up to 16 micrograms/kg/d were relatively well tolerated in the absence of extreme leukocytosis. Fatigue and myalgia were common. Three patients developed pulmonary infiltrates that resolved with discontinuation of treatment. Patients tended to have recurrent inflammation in previously diseased tissues. These data indicate that rhGM-CSF will increase circulating granulocytes, monocytes, and eosinophils in patients with refractory aplastic anemia. Further studies are necessary to determine if rhGM-CSF treatment will reduce morbidity or improve survival.
Naso-Temporal Asymmetry of Spatial Interactions in Strabismic Amblyopia (1998)

Our results suggest that intracortical connections underlying cortical spatial interactions might have been degraded by amblyopia. This degradation exists not only in the areas of the strabismic visual cortex responding to foveal stimuli but also in those responding to stimuli presented in the temporal visual fields.
Structural and Functional Characterization of Phosphoglycosyl Transferases from Human Pathogens (2020)

Bacterial virulence and viability are strongly dependent on extracellular glycoconjugates including lipopolysaccharide (LPS), capsular polysaccharide (CPS), wall teichoic acid (WTA) and glycoproteins. While these glycoconjugates are diverse in structure and function, they share a common biosynthetic logic. For example, in Gram‐negative bacteria the biosynthesis of a variety of glycoconjugates are initiated on the cytoplasmic face of the bacterial inner membrane, with a phosphoglycosyl transferase (PGT) catalyzing the first membrane‐committed step of the pathway. PGTs transfer a phosphosugar from a nucleotide‐activated donor substrate onto a polyprenol phosphate such as undecaprenol phosphate (UndP). PGTs comprise two distinct superfamilies – polytopic, with multiple membrane spanning helices, and the more recently described monotopic, which contain an unusual re‐entrant membrane intercalating helix. To date, monotopic PGTs have only been observed in bacteria, and remain underexplored antimicrobial targets. In an effort to understand NDP‐sugar specificity and inform inhibitor design, a library of monotopic PGTs from human pathogens was expressed, purified, and subjected to structural and functional characterization. Both detergent and styrene maleic acid (SMA) copolymers were assessed for solubilization towards the purification and stabilization of these challenging protein targets. These efforts have led to purified samples of diverse monotopic PGTs for activity analyses using the UMP‐Glo ™ assay and crystallization screens, which have afforded reproduceable crystals for further investigation. Support or Funding Information R01GM131627, F32GM134576
Experimental Comparison of Hemolytic and NonhemolyticOrnithobacterium rhinotrachealeField IsolatesIn Vivo (2014)

Ornithobacterium rhinotracheale (ORT) is a nonhemolytic, gram-negative, pleomorphic, rod-shaped bacterium that causes upper and lower respiratory tract disease in poultry. Recently, hemolytic strains of ORT have been isolated with increasing frequency from field outbreaks. A study was conducted to determine whether the hemolytic phenotype is associated with any change in virulence. Briefly, 225 turkey poults, vaccinated against hemorrhagic enteritis at 4 wk of age, were randomly divided into nine replicates housed in separate rooms: three sham treatment controls (25 poults/replicate), three challenged with a nonhemolytic (NH) field isolate (24 poults/replicate), and three challenged with a hemolytic (H) field isolate (24 poults/replicate). Nine days postvaccination, poults were inoculated intratracheally with either 0.2 ml sterile phosphate-buffered saline (PBS), 2 x 10(8) colony-forming units (CFU) of the NH isolate in 0.2 ml PBS, or 2 x 10(8) CFU of the H isolate in 0.2 ml PBS. Serum and body weights were obtained at 0, 7, 14, and 21 days postinoculation (dpi). Tissues were taken for culture and histopathology from five randomly selected poults/replicates at 7, 14, and 21 dpi. When compared with poults inoculated with the H isolate or controls, those inoculated with the NH isolate showed a highly significant depression in weight gain at 7 dpi. NH poults also had significantly higher levels of antibody against ORT at 14 and 21 dpi. Reisolations decreased over time and, by 21 dpi, only the NH phenotype could be found. Based on a Likert-type scale, poults inoculated with the NH isolate had significantly higher histopathologic lesion scores in lung tissue at 7, 14, and 21 dpi. Results suggest that nonhemolytic field isolates are more virulent then hemolytic ones. These findings are unusual because hemolytic phenotypes are often more virulent in other bacterial species.
Pulsed electron avalanche knife: new technology for cataract surgery (2007)

PEAK-fc is a very helpful cutting device for complicated cases of cataract surgery, especially for mature and congenital cataracts, traumatic zonulolysis or anterior segment complications after intraocular inflammation.
Raman spectroscopic characterization and molecular force field development of a synthetic polyamide: nylon 66 (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRaman spectroscopic characterization and molecular force field development of a synthetic polyamide: nylon 66C. G. Zimba, J. F. Rabolt, and A. D. EnglishCite this: Macromolecules 1989, 22, 6, 2863–2867Publication Date (Print):June 1, 1989Publication History Published online1 May 2002Published inissue 1 June 1989https://doi.org/10.1021/ma00196a061Request reuse permissionsArticle Views421Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (687 KB) Get e-Alertsclose Get e-Alerts
Preparation of Highly-Oriented Co2MnSi Films on a Non-Single-Crystalline Substrate Using a Titanium–Nitride Buffer Layer (2011)

Highly-oriented titanium–nitride films were prepared on a non-single-crystalline substrate as a buffer layer of a Co2MnSi film. Co2MnSi films prepared on the titanium–nitride buffer layer showed a high (001)-orientation and at least a B2-ordered phase even for room temperature preparation. The magnetization curve of the Co2MnSi film annealed at 600 °C showed an extremely low coercivity of 1.4 Oe in addition to a high saturation magnetization, which indicated no interdiffusion between a Co2MnSi layer and a buffer layer. These results indicate that titanium nitride is a potential material for applications based on Co2MnSi.
Design and Limitations of Non-Coincidence Correction Filters for Soundfield Microphones (2009)

The tetrahedral microphone capsule arrangement in a Soundfield microphone captures a so-called A-format signal which is then converted to a corresponding B-format signal. The phase differences between the A-format signal channels due to non-coincidence of the microphone capsules cause errors in the corresponding B-format signals and linear combinations thereof. Various strategies for designing B-format non-coincidence correction filters are compared and limitations are discussed.
ChemInform Abstract: Synthesis of Novel Acyclonucleosides Containing Pyridazine. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Data from Targeting Integrin-Linked Kinase Suppresses Invasion and Metastasis through Downregulation of Epithelial-to-Mesenchymal Transition in Renal Cell Carcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;Renal cell carcinoma (RCC) is the most common malignancy in the kidney. Antiangiogenic targeted therapies inhibit the progression of RCC, but have limited impacts on invasion or metastasis of tumor cells. Integrin-linked kinase (ILK) is a serine/threonine kinase implicated in the regulation of cell growth/survival, cell-cycle progression, epithelial–mesenchymal transition (EMT), invasion/migration, and angiogenesis. However, the role of ILK in RCC has not been evaluated. We investigated the role of ILK on cancer progression and metastasis and the therapeutic potential of ILK inhibition in RCC. Our investigation reveals that ILK is expressed at a low level in normal cells and low-stage RCC cells and is highly expressed in advanced and metastatic cells. Caki-1, a metastatic RCC cell line, showed higher expression of molecular EMT markers, including Snail and Zeb1, but decreased activity of GSK3β. Knockdown of ILK using small interference (si)-ILK minimally inhibited tumor proliferation and cell-cycle progression was not significantly affected. However, ILK knockdown suppressed the formation of stress fibers and focal adhesions and impeded phenotypic EMT markers, including cell migration and invasion, in Caki-1 and UMRC-3 cells. Finally, &lt;i&gt;in vivo&lt;/i&gt; knockdown of ILK suppressed the progression, invasion, and metastasis of primary RCC in nude mice by downregulation of EMT markers (Snail, Zeb1, vimentin, and E-cadherin). Our results show that ILK may be essential for invasion and metastasis in RCC and regulates vimentin and E-cadherin expression by regulating the EMT-related transcription factors Snail and Zeb1. These results suggest that ILK may be a potential target in RCC. &lt;i&gt;Mol Cancer Ther; 14(4); 1024–34. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Diagnostic accuracy of macular ganglion cell-inner plexiform layer thickness for glaucoma detection in a population-based study: Comparison with optic nerve head imaging parameters (2018)

The diagnostic performance of macular GCIPL scan is inferior compared to vertical CDR measured by Cirrus OCT ONH scan. Cirrus OCT ONH scan showed the best ability in detecting glaucoma in a Chinese population, suggesting it could be a good glaucoma screening tool in an Asian population.
3D optical elements for computational sensors (2003)

3D optical elements for computational sensors. We discuss geometric segmentation of optical fields by volume optical elements and 3D photonic circuits and describe example systems. 3D elements include volume holograms, geometric filters and microcavity arrays. Photonic crystals and heterogeneous integration may further extend volume capabilities.
Data from Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Angiotensin system inhibitors (ASI) can improve prognosis in multiple cancer types, including pancreatic ductal adenocarcinoma (PDAC). However, no study has examined the effect of ASIs alone or combined with adjuvant chemotherapy in resected PDAC patients.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We performed an analysis of the records of ASI users and nonuser patients with PDAC seen at Massachusetts General Hospital (Boston, MA) between January 2006 and December 2010. To identify mechanisms of ASIs in PDAC, we performed RNA sequencing (RNA-Seq) of resected primary lesions.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; A total of 794 consecutive patients were included. In 299 resected patients, ASI users experienced longer overall survival (OS) in both univariate (median OS, 36.3 vs. 19.3 months, &lt;i&gt;P&lt;/i&gt; = 0.011) and adjusted multivariate [HR, 0.505; 95% confidence interval (CI), 0.339–0.750; &lt;i&gt;P&lt;/i&gt; = 0.001] analyses. Propensity score–adjusted analysis also showed a longer median OS for chronic ASI users. In unresected patients, the beneficial effect of ASIs was significant in patients with locally advanced disease, but not in metastatic patients. RNA-Seq analysis revealed in tumors of ASI users (lisinopril) a normalized extracellular matrix, a reduced expression of genes involved in PDAC progression (e.g., WNT and Notch signaling), and an increased expression of genes linked with the activity of T cells and antigen-presenting cells. Finally, chronic use of ASI was associated with a gene expression signature that is predictive of survival in independent validation cohorts.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; In patients with nonmetastatic PDAC, chronic ASI use is associated with longer OS independently of chemotherapy. Our RNA-Seq analysis suggests that ASIs reduce the malignant potential of cancer cells and stimulate the immune microenvironment in primary PDAC. &lt;i&gt;Clin Cancer Res; 23(19); 5959–69. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Clinical Significance of Serum Biomarkers in Pediatric Solid Mediastinal and Abdominal Tumors (2012)

Childhood cancer is the leading cause of death by disease among U.S. children between infancy and age 15. Despite successes in treating solid tumors such as Wilms tumor, disappointments in the outcomes of high-risk solid tumors like neuroblastoma have precipitated efforts towards the early and accurate detection of these malignancies. This review summarizes available solid tumor serum biomarkers with a special focus on mediastinal and abdominal cancers in children.
Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer (2014)

Jumonji domain-containing protein 2B has an essential role in cancer cell survival and tumour growth via DDR mediation, which STAT3 partially regulates, suggesting that JMJD2B is a potential anti-cancer target.
Tunable room-temperature continuous-wave mid-infrared VCSELs (2020)

Over the last two years, our group has reported the first room-temperature continuous-wave (RTCW) fixed wavelength VCSELs operating above 3 microns, in both optically pumped and electrically pumped devices. Our optically pumped 3.3um devices employ one or two wafer-bonded GaAs/AlGaAs mirrors, in conjunction with a type I InGaAsSb/AlInGaAsSb quantum well active region. Our electrically pumped 3.3um devices employ a bottom waferbonded GaAs/AlGaAs mirror, top deposited ZnSe/ThF4 mirror, and type II interband cascade (ICL) active region. These fixed wavelength devices lay a foundation for tunable devices in the spectrally rich 3-5um region. Narrowly tunable devices can use thermal tuning, by variation of pump power (optically pumped devices), bias current (electrically pumped devices), or device temperature (both electrically and optically pumped devices). In this paper, we describe tunable CW optically pumped devices with &gt;4nm of tuning near 3.3um using variation of pump power. CW electrically pumped devices show ~2nm tuning near 3.3um using variation of bias current. These results are a critical first step towards an inexpensive and high-speed methane sensing source. A first generation of MEMS-tunable optically pumped devices has achieved 70nm tuning range near 3.34um.
Designing Conformal Cooling Channels for Tooling (1998)

SFF technologies have demonstrated the potential to produce tooling with cooling channels which are conformal to the molding cavity. 3D Printed tools with conformal cooling channels have demonstrated simultaneous improvements in production rate and part quality as compared with conventional production tools. Conformal Cooling lines of high performance and high complexity can be created, thus presenting a challenge to the tooling designer. This paper presents a systematic, modular, approach to the design of conformal cooling channels. Recognizing that the cooling is local to the surface of the tool, the tool is divided up into geometric regions and a channel system is designed for each region. Each channel system is itself modeled as composed of cooling elements, typically the region spanned by two channels. Six criteria are applied including; a transient heat transfer condition which dictates a maximum distance from mold surface to cooling channel, considerations of pressure and temperature drop along the flow channel and considerations of strength of the mold. These criteria are treated as constraints and successful designs are sought which define windows bounded by these constraints. The methodology is demonstrated in application to a complex core and cavity for injection molding.
Europan Molecular Indicators of Life Investigation (EMILI) Technology Development (2020)

International audience
Acetogenic isoquinoline alkaloids, XXI. An atropisomer‐differentiating reaction for the chemical analysis of axial chirality and its computational investigation: Proof of the stereostructure of dioncophylline A (1991)

Abstract A chemical method for the unambiguous elucidation of axial chirality in naphthylisoquinoline alkaloids such as dioncophylline A ( 1a ) is described. It involves synthetic connection of the stereogenic axis to be investigated with the stereocenters present in the same molecule. The resulting macrocyclic ansa compound 7c is formed in high yield, yet exclusively for only one of the two atropodiastereomers ( 4c ), the other isomer ( 4b ) does not cyclize at all. This cyclization behavior fully confirms the stereostructure 1a of dioncophylline A, as postulated by us earlier. For an interpretation of the striking atropisomer specificity of this ring closure reaction, computer‐assisted theoretical investigations on the molecular geometries and thus thermodynamical properties of both of the imaginable cyclization products 7b/c have been performed by using force‐field (MM2, MMX) and semiempirical methods (AM1). The optimized structures show the obtained macrocycle 7c to be a nonstrained, stable compound, whereas the other possible product 7b (which definitely is not formed) should be severely distorted.
The unusual electronic structure of ambipolar dicyanovinyl-substituted diketopyrrolopyrrole derivatives (2014)

We have synthesized two novel dicyanovinylene-substituted DPP–oligothiophene semiconductors, DPP-4T-2DCV and 2DPP-6T-2DCV. In these materials, the combination of an extended oligothiophene conjugated skeleton with the strong electron-withdrawing DPP–dicyanovinylene groups results in semiconductors exhibiting ambipolar TFT response with reasonably balanced electron and hole mobilities of up to 0.16 cm2 V−1 s−1 and 0.02 cm2 V−1 s−1, respectively. Furthermore, no thermal annealing of the semiconductors is necessary to afford high mobility, making them ideal candidates for low cost fabrication of devices on inexpensive plastic foils. Analysis of the molecular and electronic structures by means of electronic and vibrational spectroscopy techniques, electrochemistry and DFT calculations highlights a unique electronic scenario in these semiconductors, where the external cyano groups are isolated from the π-conjugated core. The appearance of these unusual π-systems explains the similar electron mobilities recorded for both DPP-4T-2DCV and 2DPP-6T-2DCV, despite their different skeletal dimensions. Furthermore, it also supports the appearance of moderately balanced hole and electron mobilities in semiconductors with such large accumulation of acceptor units. Transient spectroscopy measurements indicate the appearance of triplet excited state species, which may be related to the semiconductors' low performances in OPVs, due to the intrusion of triplets in the carrier formation process.