gebhart/patrepeval huggingface dataset:
Efficacy of a novel SHIP1 activator in animals and healthy human volunteers exposed to inhaled lipopolysaccharide (2012)

Introduction: Suppression of PI3K is an established pharmacological approach to control inflammation. SHIP1 suppresses the downstream effects of PI(3,4,5)P3 by converting it to PI(3,4)P2. SHIP1 deletion in mice results in pulmonary inflammation, and in humans, SHIP1 protein levels negatively correlate with basophil activity. Objective : To determine the effects of AQX-1125, a small molecule SHIP1 activator, on airway inflammation in animals and humans. Methods: The efficacy of AQX-1125 on LPS-induced pulmonary inflammation was evaluated in SHIP1 +/+ and SHIP1 -/- mice, and on bronchoalveolar lavage (BAL) cell counts and inflammatory mediators of LPS-challenged rats. The ability of oral AQX-1125 (450 mg QD, 7 days) to inhibit LPS-induced airway neutrophilia in healthy human subjects (n=18) was evaluated in induced sputum in a randomized, placebo-controlled, double-blind, two-way crossover study. Results: AQX-1125 inhibited LPS-induced pulmonary neutrophilia in SHIP1 +/+ but not not SHIP1 -/- mice. AQX-1125 dose-dependently inhibited airway neutrophilia and inflammatory mediators in LPS-challenged rats (p In humans, AQX-1125 reduced LPS-induced neutrophilia. Prior to LPS exposure, sputum neutrophil cell counts were the same between treatment groups (Geometric Least Squares Mean - GLSM AQX-1125/placebo ratio = 0.96, 90% CI 0.27-3.38). Post-LPS exposure (24 h), AQX-1125 reduced the sputum neutrophils by 66% (GLSM ratio = 0.34, 90% CI 0.13-0.92). Conclusions: These data demonstrate efficacy of AQX-1125 in human and rodent pulmonary inflammation models, supporting the importance of SHIP1 as a novel target and the clinical development of AQX-1125 for inflammatory disease.
Sudden short circuiting of synchronous machines by EMTP (2003)

Abstract Applying ATP‐EMTP for the purpose of better understanding of rotating machine transients, several kinds of model synchronous machines with typical features were analyzed in the time domain with respect to sudden short circuiting, and the calculated currents and flux linkages during transient time interval were plotted on the d–q domain planes. Many interesting current/flux vector traces, representing rotating machine transients during short circuiting, were obtained. These may be helpful for understanding transients in rotating machines. © 2003 Wiley Periodicals, Inc. Electr Eng Jpn, 146(1): 78–88, 2004; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.10228
Combined Lane Keeping and Longitudinal Speed Control for Autonomous Driving (2019)

Abstract This paper presents a technique for the lane keeping and the longitudinal speed control of an autonomous vehicle with the combination of an MPC and a PID control. The goal of the proposed control method is to minimize the lateral deviation and relative yaw angle with respect to the planned trajectory, while driving the vehicle at the highest acceptable longitudinal speed. The reference profile of the longitudinal speed is computed considering both the lateral and longitudinal dynamic of the vehicle. The vehicle is represented by means of a linear 3-DoF bicycle model. The control algorithm takes the road lane boundaries as the only external input. The proposed strategy is validated in simulation on three distinct driving scenarios.
1,2-Asymmetric induction in reactions of nonconjugated acyclic radicals: a new model for highly selective atom-transfer reactions of alkyl-substituted radicals (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1,2-Asymmetric induction in reactions of nonconjugated acyclic radicals: a new model for highly selective atom-transfer reactions of alkyl-substituted radicalsGebhard Thoma, Dennis P. Curran, Steven V. Geib, Bernd Giese, Wolfgang Damm, and Frank WetterichCite this: J. Am. Chem. Soc. 1993, 115, 19, 8585–8591Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/ja00072a010https://doi.org/10.1021/ja00072a010research-articleACS PublicationsRequest reuse permissionsArticle Views520Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Analysis of modified layer formation into silicon wafer by permeable nanosecond laser (2006)

When a permeable nanosecond pulse laser which is focused into the inside of a silicon wafer is scanned in the horizontal direction, a belt-shaped high dislocation density layer including partially polycrystalline region is formed at an arbitrary depth in the wafer. Applying tensile stress perpendicularly to this belt-shaped modified-layer, silicon wafer can be separated easily into individual chip without creating any damage to the wafer surface comparing with the conventional blade dicing method, because the cracks that spread from the modified layer up and down progress to the surface. This technology is called “stealth dicing” (SD), and attracts attentions as a novel dicing technology in semiconductor industries. The purpose of this study is to clarify the formation mechanism of modified layer. We paid attention to an experimental result that the absorption coefficient varies with temperature. We analyzed a coupling problem composed of focused laser propagation in a silicon single crystal, laser absorption, temperature rise, and heat conduction. Simple thermal stress analysis was also conducted based on those results. As a result, formation mechanism of the modified layer could be explained clearly. Temperature dependence of absorption coefficient is the most important factor of the modified layer formation. The present analysis can be applied to find the optimum laser irradiation condition for SD method, and it is a future subject to confirm it experimentally. It was supported by the present analysis that the problem of thermal effect on the active region can be solved by the SD method. SD method for wafer dicing is original firstly and it is valuable that formation mechanism of the modified layer in SD method was clarified theoretically.
High temperature superconducting current leads for cryogenic applications in moderate magnetic fields (1991)

Large YBa/sub 2/Cu/sub 3/O/sub 7- delta / ceramic conductors suitable for bulk current applications have been fabricated using a magnetic technique to generate c-axis grain alignment. Critical currents on the order of several hundred amperes in a background field of 0.1 T have been achieved as a result of the aligned microstructure. The unusual dependence of the critical current on temperature and magnetic field is discussed in the context of anisotropy, self-field, and hysteretic effects.
ChemInform Abstract: A Novel Approach to Amidines from Esters. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Erratum to: Study of ϒ production in pPb collisions at $$ \sqrt{s_{\mathrm{NN}}} $$ = 8.16 TeV (2020)

In figure 11 of the original paper.
Microfluidic chemostat and turbidostat with flow rate, oxygen, and temperature control for dynamic continuous culture (2011)

This work reports on an instrument capable of supporting automated microscale continuous culture experiments. The instrument consists of a plastic-PDMS device capable of continuous flow without volume drift or evaporation. We apply direct computer controlled machining and chemical bonding fabrication for production of fluidic devices with a 1 mL working volume, high oxygen transfer rate (k(L)a≈0.025 s(-1)), fast mixing (2 s), accurate flow control (±18 nL), and closed loop control over temperature, cell density, dissolved oxygen, and pH. Integrated peristaltic pumps and valves provide control over input concentrations and allow the system to perform different types of cell culture on a single device, such as batch, chemostat, and turbidostat continuous cultures. Continuous cultures are demonstrated without contamination for 3 weeks in a single device and both steady state and dynamically controlled conditions are possible.
Nonproportionality of Scintillator Detectors: Theory and Experiment (2009)

On the basis of nonproportionality data obtained for several scintillators, we have developed a model to describe the carrier dynamics to fit the light yield versus electron energy. The theory of Onsager was adapted to explain how the carriers form excitons or sequentially arrive at the activators to promote the ion to an excited state, and the theory of Birks was employed to allow for exciton-exciton annihilation. We then developed a second model to deduce the degradation in resolution that results from nonproportionality by evoking Landau fluctuations, which are essentially variations in the deposited energy density that occur as the high energy electron travels along its trajectory. In general there is agreement with the data, in terms of fitting the nonproportionality curves and reproducing the literature values of nonproportionality's contribution to the scintillator resolution.
Personalized DNA neoantigen vaccine in combination with plasmid IL-12 for the treatment of a patient with anaplastic astrocytoma. (2021)

e14561 Background: Tumor neoantigens are epitopes derived from tumor-specific mutations that may be incorporated in personalized vaccines to prime T cell responses. DNA vaccines delivered with electroporation have recently shown strong CD8 and CD4 T cell responses in clinical trials. In preclinical studies, DNA-encoded neoantigen vaccines have shown induction of CD8 T cells against 50% of predicted high affinity epitopes with the ability to impact tumor growth. Methods: Two resection samples from a patient with IDH+ MGMT-methylated anaplastic astrocytoma were subject to whole exome and transcriptome sequencing. Epitopes derived from 27 neoantigens and 3 shared tumor-associated antigens were prioritized and included in a personalized vaccine. The patient was treated with surgery, radiotherapy and temozolomide starting June 2018 and received the first dose of the personalized vaccine in June 2019 under a compassionate use single patient IND application with the FDA. Results: As of February 10, 2021, the patient has received 10 doses of the DNA personalized vaccine. No serious adverse events have been reported. Related adverse events are limited to grade 1 injection site reactions. The patient remains progression-free 32 months after surgery and 20 months after starting vaccination. Three weeks following the third dose, a hyperintense image on the tumor bed was identified, which disappeared on the following MRI, 2 weeks following dose 5, being catalogued as pseudo progression. Ex vivo ELISpot have identified T cell responses to 21/30 epitopes (70%), including 18/27 (67%) neoantigens and 3/3 (100%) shared antigens. Flow cytometry analysis has determined that T cell responses are 92.3% CD8 and 69.2% CD4 (30.8% CD8 only; 61.5% both CD8 and CD4; and 7.7% CD4 only). Conclusions: This compassionate use treatment in an adjuvant setting demonstrates manufacturing feasibility, safety, tolerability, immunogenicity, and suggests potential for persistent clinical response of DNA encoded personalized vaccines. The data supports further investigation of DNA-encoded personalized vaccines into newly diagnosed high-grade gliomas.
Data Pattern & Memory Variation Aware Fine-Grained ECC Optimized by Neural Network for 3D-TLC NAND Flash Memories with 2.0x Data-Retention Time Extension and 30% Parity Overhead Reduction (2019)

This paper proposes fine-grained ECC optimized by Neural Network (NN) for 3D-TLC NAND flash memories. Among 48 combinations of 8 reliability enhancement techniques (RETs) and 6 BCH ECCs, proposed NN automatically selects the optimal combination of RET and BCH ECC. Errors with complicated data pattern dependence and memory variations are adaptively compensated. In addition, the design trade-off between the high reliability and parity overhead (cost) is resolved. As a result, both high reliability and small parity overhead are realized simultaneously. The acceptable data-retention time increases by 2.0-times and the data overhead decreases by 30%.
Distributed feedback modes in a partially filled ring cavity (1987)

We have studied the threshold longitudinal modes of a structure composed of a ring cavity partially filled with a distributed feedback (DFB) medium. An eigenvalue equation and dispersion relation for the propagation constant, threshold gain, and mode location are derived and numerically solved for a number of cases. We show that the incommensurate nature of the unfilled ring cavity eigenfrequencies and DFB eigenfrequencies can lead to an enhancement of the frequency selectivity of the distributed feedback laser. The analysis is extended to consider finite linewidth and dispersion.
Development of a New Force Field for Polynorbornene (1998)

A new force field has been customized for the variation of polynorbornene that contains a bicycloheptane group in the backbone structure. The force field was developed from ab initio density functional theory (DFT), and semiempirical electronic structure calculations for both stereochemical dimers of the 2,3 exo−exo isomer of polynorbornene. The bond length and bond angle parameters were determined using the HF/6-311G** ab initio SCF method. The intrinsic torsion potential was determined using the AM1 semiempirical method and the van der Waals parameters are kept same as in the Dreiding 2.21 force field. Both the bonded and torsional energy functions compared well to DFT calculations. The equilibrium geometry and the torsional energetics of the customized force field differ significantly from generic force fields such as Dreiding. Comparisons to experimentally determined geometry and infrared and Raman spectra were used to determine the optimum ab initio and semiempirical method to use for force field parametrization. The new force field reproduces a polynorbornene dimer crystal structure to a high degree of accuracy.
Development of Stem Cell-Based Therapy for Limbal Stem Cell Deficiency—From Tissue Stem Cell to iPS Cell (2019)

Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan. Correspondence: Kohji Nishida, MD, PhD, Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan (e-mail: [email protected]). Supported in part by the Japan Agency for Medical Research and Development (AMED) under Grant Number JP19bm0504005 and JP19bk0104080, the Japan Science and Technology Agency (JST), The Ministry of Health, Labour and Welfare of Japan, and Grants-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science and Technology of Japan. The author has no conflicts of interest to disclose.
Efficient Light Harvesting of pin-Type a-Si:H Solar Cells by Implementing an n-a-SiOx:H/LiF Interlayer (2014)

We have developed an hydrogenated n-type amorphous silicon oxide (n-a-SiOx:H)/lithium fluoride (LiF) interlayer for effective light trapping in pin-type hydrogenated amorphous silicon (a-Si:H)-based solar cells with a 200-nm-thick intrinsic a-Si:H absorber. The spectral response of the fabricated solar cell is clearly enhanced in the wide wavelength range of 500-800 nm because of the reduced plasmonic absorption and effective refractive index grading. As a result, the short-circuit current is improved by 10.7% (from 13.1 to 14.5 mA/cm2). Consequently, we have achieved the highest conversion efficiency of 9.0%, which confirms the possibility of cost-effective thin a-Si:H-based solar cells.
Biomimetic Synthesis of Calcium Carbonate Thin Films Using Hydroxylated Poly(methyl methacrylate) (PMMA) Template (2006)

Morphosynthesis of calcium-rich materials by tuning the chemical structure of organic matrices has tremendous potential in the preparation of functional mineralized materials. In this paper, we have demonstrated the deposition of thin films of CaCO3 by subtle modifications of the backbone of poly(methyl methacrylate) (PMMA) by the incorporation of many hydroxyl groups. The water-insoluble hydroxylated PMMA (HyPMMA) was used as a template along with poly(acrylic acid) (PA) as an additive for CaCO3 mineralization. Thin film deposition was controlled by the addition of an appropriate amount of PA to the crystallization medium. At lower concentrations (PA = 50 and 100 μg/mL), irregular aggregates of calcite crystallites were formed. As the concentration of PA was increased (500 μg/mL and 1 mg/mL), calcite thin films were deposited. Time-dependent crystallization showed that the precipitates obtained after 3 h were biphasic in structure, consisting of both amorphous and crystalline domains. Observations suggest that crystal aggregates and thin films were formed through a multistep mechanism in which an amorphous phase was deposited initially and was subsequently transformed into stable crystalline form. In contrast, mineralization in the presence of HyPMMA or PA alone yielded only calcite or calcite aggregates. Our results indicate that a concerted interplay of interactions between the insoluble polymer matrix (HyPMMA) and soluble PA determines the growth and morphology of CaCO3 by influencing the transformation of amorphous calcium carbonate (ACC) into the crystalline phase. More specifically, we have investigated the interplay of the role of acid groups on PA and accelerating alcohol groups on HyPMMA in calcium carbonate crystallization.
What the Seller Won't Tell You: Persuasion and Disclosure in Markets (2008)

Imagine that you are considering an investment in a new public offering of a firm's shares. The firm's officers make a presentation that includes an audited financial statement, an earnings forecast reviewed by its prestigious investment bankers, and an impressive demonstration of its new technology. Or suppose that you are buying a new furnace to replace an old one that is not working well. The salesman displays a chart showing that the projected total life-cycle cost of one particular model, including capital costs and fuel usage over the projected lifetime of the furnace, is lower than that of some competing models you have considered. This paper reviews the theoretical arguments about how sellers disclose information in an attempt to encourage buyers, and the potential role for regulation in encouraging efficient disclosure of information. How well does a system of private reporting work? When should we expect all the relevant information to be reported? If testing and reporting by the seller are costly, will too little testing and reporting be done? Or too much? When some information is withheld, what sort of information is withheld? How do rational buyers respond to such withholding? How are prices and welfare affected? What role is there for laws and regulations to improve the functioning of markets? We address these questions by studying the theory of persuasion games—games in which one or more sellers provide verifiable information to buyers to influence the actions they take.
Flexible Ureteroscopy: Washington University Experience With the 9.3F and 7.5F Flexible Ureteroscopes (1997)

For ureteral and renal pathological conditions the 7.5F ureteroscope is as effective as the 9.3F instrument diagnostically and therapeutically. The 7.5F ureteroscope usually can be used with sedation analgesia. Also, the smaller 7.5F ureteroscope is associated with less need for active ureteral dilation, minimal postoperative discomfort and a brief hospital stay.
Mutual disambiguation of 3D multimodal interaction in augmented and virtual reality (2003)

We describe an approach to 3D multimodal interaction in immersive augmented and virtual reality environments that accounts for the uncertain nature of the information sources. The resulting multimodal system fuses symbolic and statistical information from a set of 3D gesture, spoken language, and referential agents. The referential agents employ visible or invisible volumes that can be attached to 3D trackers in the environment, and which use a time-stamped history of the objects that intersect them to derive statistics for ranking potential referents. We discuss the means by which the system supports mutual disambiguation of these modalities and information sources, and show through a user study how mutual disambiguation accounts for over 45% of the successful 3D multimodal interpretations. An accompanying video demonstrates the system in action.
Combinatiorial Synthesis in Micro Reactors (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Influence of Follicular Maturation on Inhibition of Luteinizing Hormone-, Cyclic 3′, 5′-Adenosine Monophosphate-, and Forskolin-Stimulated Progesterone Production in Chicken Ovarian Granulosa Cells Exposed to Bursal Anti-Steroidogenic Peptide1 (1995)

Previously, we demonstrated that a peptide from chicken bursa of Fabricius, bursal anti-steroidogenic peptide (BASP), inhibited LH-stimulated progesterone biosynthesis by granulosa cells from the two largest preovulatory follicles of the chicken ovary. In the present study, we investigated the influence of follicular maturation on the ability of BASP to inhibit granulosa cell steroidogenesis. Granulosa cells from the largest (F1), third largest (F3), and fifth largest (F5), preovulatory follicles of the laying hen were exposed to BASP in the presence or absence of ovine LH, forskolin, or dibutyryl-cAMP (db-cAMP). BASP (0.125 or 0.25 bursal equivalents [BEQ]) suppressed basal progesterone production in F5, but not in F1 or F3, granulosa cells. BASP suppressed LH-stimulated progesterone production in F1, F3, and F5 granulosa cells in a concentration-dependent manner; however, the lowest level (0.06 BEQ) did not suppress progesterone production in F5 granulosa cells. All levels of BASP suppressed forskolin-stimulated progesterone production in F1 granulosa cells, but only the highest level (0.25 BEQ) inhibited forskolin-stimulated steroidogenesis in F3 and F5 granulosa cells. Similar results were obtained with db-cAMP-stimulated granulosa cells. The inhibitory effects of BASP on F1, F3, and F5 granulosa cells were directly compared on a percentage basis. In the presence of each secret-agogue, the lowest level (0.06 BEQ) of BASP effectively suppressed progesterone synthesis in F1 and F3 but not F5 granulosa cells. At higher levels, there was no consistent difference in the ability of BASP to suppress stimulated progesterone production in granulosa cells at different stages of maturation.(ABSTRACT TRUNCATED AT 250 WORDS)
Soft Error Sensitivities in 90 nm Bulk CMOS SRAMs (2009)

Enhanced single event upset (SEU) sensitivity to low energy protons, as much as 5-6 orders of ten, has been observed in 90 nm epitaxial-bulk complementary metal oxide semiconductor (CMOS) static random access memories (SRAM). Enhancements to process and cell design are discussed.