gebhart/patrepeval huggingface dataset:
Genome-Wide Association Study of Young-Onset Hypertension in the Han Chinese Population of Taiwan (2009)

Young-onset hypertension has a stronger genetic component than late-onset counterpart; thus, the identification of genes related to its susceptibility is a critical issue for the prevention and management of this disease. We carried out a two-stage association scan to map young-onset hypertension susceptibility genes. The first-stage analysis, a genome-wide association study, analyzed 175 matched case-control pairs; the second-stage analysis, a confirmatory association study, verified the results at the first stage based on a total of 1,008 patients and 1,008 controls. Single-locus association tests, multilocus association tests and pair-wise gene-gene interaction tests were performed to identify young-onset hypertension susceptibility genes. After considering stringent adjustments of multiple testing, gene annotation and single-nucleotide polymorphism (SNP) quality, four SNPs from two SNP triplets with strong association signals (-log(10)(p)>7) and 13 SNPs from 8 interactive SNP pairs with strong interactive signals (-log(10)(p)>8) were carefully re-examined. The confirmatory study verified the association for a SNP quartet 219 kb and 495 kb downstream of LOC344371 (a hypothetical gene) and RASGRP3 on chromosome 2p22.3, respectively. The latter has been implicated in the abnormal vascular responsiveness to endothelin-1 and angiotensin II in diabetic-hypertensive rats. Intrinsic synergy involving IMPG1 on chromosome 6q14.2-q15 was also verified. IMPG1 encodes interphotoreceptor matrix proteoglycan 1 which has cation binding capacity. The genes are novel hypertension targets identified in this first genome-wide hypertension association study of the Han Chinese population.
Effect of oxygen precipitation on phosphorus diffusion in Czochralski silicon (1988)

The effects of oxygen precipitation and surface films (SiO2 vs Si3N4) on P diffusion at 1100 °C in Czochralski silicon have been studied. With a fast precipitation rate, P diffusion under both kinds of films is enhanced because of the supersaturation of Si interstitials caused by oxygen precipitation. The larger enhancement in P diffusion under Si3N4 than that under SiO2 covered with Si3N4 is attributed to the slower recombination velocity of interstitials at the Si3N4/Si interface. P diffusion in a denuded zone behaves like that in float-zone Si until the interstitials generated under that zone arrive at the interface.
Visualization of Local Gate Depletion in PMOSFETs Using Unique Backside Etching and Selective Etching Technique (1999)

Abstract A novel backside-analysis technique has been developed to identify the locations of failing transistors in manufactured LSIs. Local gate doping depletion in p+ salicide gates of PMOSFETs, which reduces drain current, was visualized for the first time. Our method consists of backside etching and subsequent selective wet etching of the gate electrode. Si substrate material was removed with a highly selective Si etchant without damaging the gate-oxide film. After the gate-oxide film removal, a locally depleted gate was selectively etched using the same etchant. Since the etching rates of nondoped Si and n+ Si are much higher than that of p+ Si for the etchant, the depleted p+ gates were well defined. Through TEM observation, we found that a large grain lay on an active channel region of a PMOSFET. This led us to attribute the gate depletion to the difference in the impurity diffusion between large and small grains. This demonstration confirmed that our technique should be quite useful for identifying failing transistor locations in manufactured memory and logic LSIs.
Asymmetric hydrogenation of ethyl pyruvate over aqueous dispersed Pt nanoparticles stabilized by a cinchonidine-functionalized β-cyclodextrin (2020)

Cinchonidine-functionalized β-cyclodextrin was used as stabilizing agent for platinum nanoparticles dispersed in water, but also as chiral modifier for the asymmetric hydrogenation of ethyl pyruvate at 30 °C under 40 bar of hydrogen. This functionalized cyclodextrin allowed getting more stable, more catalytically active and also more enantioselective Pt nanoparticles compared to control catalytic systems. NMR and MALDI-MS analyses clearly showed the reduction of the vinyl group of the cinchonidine graft during the nanoparticles preparation. Under hydrogen pressure, the hydrogenation of the quinolinic moiety was also proven and can be responsible for the difficulties encountered during the recycling study.
Molecular characterization of a fungal cyclophilin allergen Rhi o 2 and elucidation of antigenic determinants responsible for IgE–cross-reactivity (2019)

Cyclophilins are structurally conserved pan-allergens showing extensive cross-reactivity. So far, no precise information on cross-reactive IgE-epitopes of cyclophilins is available. Here, an 18-kDa IgE-reactive cyclophilin (Rhi o 2) was purified from <i>Rhizopus oryzae</i>, an indoor mold causing allergic sensitization. Based on LC-MS/MS-derived sequences of natural Rhi o 2, the full-length cDNA was cloned, and expressed as recombinant (r) allergen. Purified rRhi o 2 displayed IgE-reactivity and basophil degranulation with sera from all cyclophilin-positive patients. The melting curve of properly folded rRhi o 2 showed partial refolding after heat denaturation. The allergen displayed monomeric functional peptidyl-prolyl <i>cis-trans</i> isomerase (PPIase) activity. In IgE-inhibition assays, rRhi o 2 exhibited extensive cross-reactivity with various other cyclophilins reported as allergens from diverse sources including its homologous human autoantigen. By generating a series of deletion mutants, a conserved 69-residue (Asn<sup>81</sup>-Asn<sup>149</sup>) fragment at C terminus of Rhi o 2 was identified as crucial for IgE-recognition and cross-reactivity. Grafting of the Asn<sup>81</sup>-Asn<sup>149</sup> fragment within the primary structure of yeast cyclophilin CPR1 by replacing its homologous sequence resulted in a hybrid molecule with structural folds similar to Rhi o 2. The IgE-reactivity and allergenic activity of the hybrid cyclophilin were greater than that of CPR1. Therefore, the Asn<sup>81</sup>-Asn<sup>149</sup> fragment can be considered as the site of IgE recognition of Rhi o 2. Hence, Rhi o 2 serves as a candidate antigen for the molecular diagnosis of mold allergy, and determination of a major cross-reactive IgE-epitope has clinical potential for the design of next-generation immunotherapeutics against cyclophilin-induced allergies.
Modeling of Complex Manufacturing Processes by Hierarchical Fuzzy Basis Function Networks With Application to Grinding Processes (2004)

A framework for modeling complex manufacturing processes using fuzzy neural networks is presented with a novel training algorithm. In this study, a hierarchical structure that consists of fuzzy basis function networks (FBFN) is proposed to construct comprehensive models of the complex processes. A new adaptive least-squares (ALS) algorithm, based on the least-squares method and genetic algorithm (GA), is proposed for autonomous learning and construction of FBFNs without any human intervention. Simulation studies are performed to demonstrate advantages of the proposed modeling framework with the training algorithm in modeling complex manufacturing processes. The proposed method is implemented for the surface grinding processes based on the hierarchical structure of FBFNs. Process models for surface roughness and residual stress are developed based on the available grinding model structures with a small number of experimental data to demonstrate the concept. The accuracy of developed models is validated through independent sets of grinding experiments.
An xpath-based discourse analysis module for spoken dialogue systems (2004)

This paper describes an XPath-based discourse analysis module for Spoken Dialogue Systems that allows the dialogue author to easily manipulate and query both the user input's semantic representation and the dialogue context using a simple and compact formalism. We show that, in managing the human-machine interaction, the discourse context and the dialogue history are effectively represented as Document Object Model (DOM) structures. DOM defines interfaces that dialogue scripts can use to dynamically access and update the content, the structure and the style of the documents. In general, this approach applies also to richer multimedia and multimodal interactions where the interpretation of the user input depends on a combination of input modalitie.
Mastering the element of competition Periodic: A Game of the Elements John J. Coveyou and Paul Salomon Illustrator: Tomasz Bogusz Genius Games, 2019. (2019)

Players race to research the periodic table in an engaging new board game
Comparative Analysis of the Impact of Additively Manufactured Polymer Tools on the Fiber Configuration of Injection Molded Long-Fiber-Reinforced Thermoplastics (2020)

Additive tooling (AT) utilizes the advantages of rapid tooling development while minimizing geometrical limitations of conventional tool manufacturing such as complex design of cooling channels. This investigation presents a comparative experimental analysis of long-fiber-reinforced thermoplastic parts (LFTs), which are produced through additively manufactured injection molding polymer tools. After giving a review on the state of the art of AT and LFTs, additive manufacturing (AM) plastic tools are compared to conventionally manufactured steel and aluminum tools toward their qualification for spare part and small series production as well as functional validation. The assessment of the polymer tools focuses on three quality criteria concerning the LFT parts: geometrical accuracy, mechanical properties, and fiber configuration. The analysis of the fiber configuration includes fiber length, fiber concentration, and fiber orientation. The results show that polymer tools are fully capable of manufacturing LFTs with a cycle number within hundreds before showing critical signs of deterioration or tool failure. The produced LFTs moldings provide sufficient quality in geometrical accuracy, mechanical properties, and fiber configuration. Further, specific anomalies of the fiber configuration can be detected for all tool types, which include the occurrence of characteristic zones dependent on the nominal fiber content and melt flow distance. Conclusions toward the improvement of additively manufactured polymer tool life cycles are drawn based on the detected deteriorations and failure modes.
Hydrogel-Based Scaffolds in Oral Tissue Engineering (2021)

Regenerative therapy in dentistry has gained interest given the complexity to restore dental and periodontal tissues with inert materials. The best approach for regeneration requires three elements for restoring functions of affected or diseased organ tissues: cells, bioactive molecules, and scaffolds. This triad is capable of modulating the processes to replace lost or damaged tissues and restore function, as it has an impact on diverse cellular processes, influencing cell behavior positively to induce the complete restoration of function and morphology of such complex tissues. Hydrogels (HG) have shown advantages as scaffolds as they are soft and elastic three-dimensional (3D) networks formed from hydrophilic homopolymers, copolymers, or macromers. Besides simple or hybrid, HG show chemical, mechanical and biological activities such as the incorporation of cells in their structures, the retention of high-water content which enhances the transportation of cell nutrients and waste, and elastic and flexible characteristics that emulate the native extracellular matrix (ECM). HG can induce changes in cellular processes such as chemotaxis, proliferation, angiogenesis, biomineralization, and expression of specific tissue biomarkers, enhancing the regeneration process. Besides some of them have anti-inflammatory and anti-bacterial effects. This review aims to show an extensive overview of the most used hydrogels in tissue engineering, emphasizing those that are studied for the regeneration of oral tissues, their biological effects, and their clinical implications. Even though most of the HG are still under investigation, some of them have been studied in vitro and in vivo with outstanding results that may lead to preclinical studies. Besides there are HG that have shown their efficacy in patients such as hyaluronan HG that enhances the healing of gingival tissue.
Temporal genetic structure of an intergrade largemouth bass (Micropterus salmoides) population (1994)

Abstract Since 1972, numerous impoundments throughout Texas have been stocked with Florida largemouth bass Micropterus salmoides floridanus. In order to examine some of the long‐term effects of such efforts, the present study summarizes past studies and complements those with more current observations on the intergrade largemouth bass population in Aquilla Lake, Hill Country, Texas. The reservoir received 4 annual stockings during the month of May from 1982 to 1985. Collections occurred periodically from February 1984 to June 1987, February to August 1988, and monthly from August 1991 to November 1992. Horizontal starch‐gel electrophoresis was conducted to determine allele frequencies at loci sAAT‐B* , SOD*1 . Mean heterozygosity and percent introgression were highest for age‐0 fish of the 1986 year class. Assortative mating was not apparent in 1991 or 1992 year classes. Collections of specific year classes over time consistently indicated decreases in the relative abundance of the northern phenotype. Relative to the northern phenotype, the abundance of Florida year classes remained relatively constant over time. Relative abundances of F 1 hybrids and F x , intergrades (i. e., F 1 ) from specific year glasses were observed to generally increase with age.
Weak Bonds, Strong Effects: Enhancing the Separation Performance of UiO-66 toward Chlorobenzenes via Halogen Bonding (2023)

Halogen bonding (HaB) is a weak interaction that assists in the recognition of nucleophilic molecules. However, HaB elements are currently under-investigated as a part of functional materials in separation science. Herein, we develop a novel approach for introducing HaB elements into UiO-66 to fine-tune the adsorption properties toward chlorobenzenes (CBs). A series of UiO-66 containing various contents of 2-iodoterephtalic acid (I-TA) (0%, 33%, 50%, 67%, and 100%) was prepared, characterized, and applied for the selective removal of CB contaminants from nonchlorinated aromatic analogues that cannot be separated by common distillation. Investigation of the structure–property relationship revealed that the highest adsorption capacity was achieved in the case of UiO-66 loaded with 50% I-TA (UiO-66-Iopt), and this was attributed to the balance between the number of HaB elements and the surface area of the UiO-66 structure. According to density functional theory calculations, the formation of a conjugate between dichlorobenzene and UiO-66-Iopt was more energetically favorable (up to 1.7 kcal/mol) than that of the corresponding conjugate with UiO-66. The formation of HaBs was experimentally verified by UV–vis, Raman, and X-ray photoelectron spectroscopies. To obtain functional materials for separation applications, waste polyethylene terephthalate (PET) was used as a support and feedstock for the surface-assisted growth of UiO-66-Iopt. The as-prepared PET@UiO-66-Iopt exhibited a close-to-perfect selectivity and reusability for the separation of a wide range of CBs from nonchlorinated aromatic analogues.
Ceramic bearings for total hip arthroplasty are associated with a reduced risk of revision for infection (2018)

In this registry-based material, use of a CoC bearing was associated with a lower risk of revision for infection in patients younger than 70 years when cementless femoral components were used. Further studies are needed to verify this finding.
Design, synthesis and cytotoxicity evaluation of novel ( E )-3-(3-aryl-1-phenyl-1 H -pyrazol-4-yl)-1-(pyridin-3-yl)prop-2-en-1-ones as anticancer agents (2016)

Abstract ( E )-3-(3-Aryl-1-phenyl-1 H -pyrazol-4-yl)-1-(pyridin-3-yl)prop-2-en-1-ones 4a–i have been synthesized and evaluated for their in vitro cytotoxicity against a panel of three human cancer cell lines Caco-2, MIA PaCa-2, MCF-7 and a normal NIH-3T3 cell line. Compound 4g is cytotoxic with the IC 50 value of 15.32±0.62 μ m against the Caco-2 cell line.
Dual-Mode Time Domain Multiplexed Chirp Spread Spectrum (2023)

In this work, we introduce dual-mode (DM) time domain multiplexed (TDM) chirp spread spectrum (CSS), which offers improved spectral and energy efficiency for low-power wide-area networks (LPWANs). Previous work on LPWANs has proposed DM-CSS modulation using even and odd frequency shifts (FSs) to enhance performance over classical approaches. However, its spectral efficiency is only half that of the in-phase and quadrature (IQ)-TDM-CSS scheme, which employs IQ components with both up and down chirps, resulting in a four times higher SE of Long Range (LoRa). IQ-TDM-CSS only supports coherent detection and is sensitive to the carrier frequency and phase offsets. It makes it less practical for low-cost battery-powered LPWANs in Internet-of-Things (IoT) applications. In contrast, DM-CSS utilizes either an up-chirp or a down-chirp and consists of two chirped symbols that are multiplexed in the time domain. One of these symbols is chirped using an up-chirp and comprises even and odd FSs. The second chirped symbol is also composed of even and odd FSs, which are chirped using a down-chirp. We demonstrate that DM-TDM-CSS achieves a maximum achievable SE close to IQ-TDM-CSS while supporting both coherent and non-coherent detection. Moreover, unlike IQ-TDM-CSS, DM-TDM-CSS is robust against carrier frequency and phase offsets, making it more suitable for low-cost, battery-powered LPWANs in IoT applications.
A 5/sup th/-order continuous-time harmonicrejection G/sub M/C filter with in-situ calibration for use in transmitter applications (2005)

A 0.18 /spl mu/m CMOS fifth-order harmonic-rejection G/sub m/C filter is presented for use in offset PLL transmitter applications. Using an in-situ calibration scheme with a tuning accuracy of 2% and a maximum calibration time of 90 /spl mu/s, this filter tunes from 52 to 151MHz and draws 7mA from a 1.8V supply while achieving an IIP3 of 7dBV with an output noise floor of 9.3 /spl mu/V in a 30kHz BW.
Label-Free Iron Oxide Nanoparticles as Multimodal Contrast Agents in Cells Using Multi-Photon and Magnetic Resonance Imaging (2021)

The obtained results indicated that IONPs could be used for fluorescence label-free bioimaging at multiple wavelengths, which was proven by multiphoton imaging of IONPs internalization in A549 cancer cells.
UWB Air-to-Ground Propagation Channel Measurements and Modeling Using UAVs (2019)

This paper presents an experimental study of the air-to-ground (AG) propagation channel through ultrawideband (UWB) measurements in an open area using unmanned-aerial-vehicles (UAVs). Measurements were performed using UWB radios operating in the frequency range of 3.1 GHz-4.8 GHz and UWB planar elliptical dipole antennas having an omni-directional pattern in the azimuth plane and typical donut shaped pattern in the elevation plane. Three scenarios were considered for the channel measurements: (i) two receivers (RXs) at different heights above the ground and placed close to each other in line-of-sight (LOS) with the transmitter (TX) on the UAV and the UAV is hovering; (ii) RXs in obstructed line-of-sight (OLOS) with the UAV TX due to foliage, and the UAV is hovering; and, (iii) UAV moving in a circular path. Different horizontal and vertical distances between the RXs and the TX were used in the measurements. In addition, two different antenna orientations were used on the UAV antennas (vertical and horizontal) to analyze the effects of antenna radiation patterns on the UWB AG propagation. From the empirical results, it was observed that the received power depends mainly on the antenna radiation pattern in the elevation plane when the antennas are oriented in the same direction, as expected for these omni-azimuth antennas. Moreover, the overall antenna gain at the TX and RX can be approximated using trigonometric functions of the elevation angle. The antenna orientation (polarization) mismatch increases path loss, and produces a larger number of weak multipath components (MPCs) than when aligned. Similarly, additional path loss and a larger number of MPCs were observed for the OLOS scenario. In the case of the UAV moving in a circular path, the antenna orientation mismatch has smaller effects on the path loss than when the UAV is hovering, because a larger number of cross polarized components are received during motion. A statistical channel model for UWB AG propagation is built from the empirical results.
Switching Controller-less Approach and Contact Controls Based on Force Impulse Regulator (2020)

This paper proposes an approach and contact controls based on the force impulse regulator. The force impulse regulator is constructed using two-spring resonant system using the motor-side velocity control and the force and position sensors integrated disturbance disturbance observer (FPIDO). Control gains are determined using pole placement method and the force impulse command is determined according to desired approach speed. The proposed approach is verified through the numerical simulation and experimental results.
Identification of stepped changes of binding affinity during interactions between the disintegrin rhodostomin and integrin α IIb β 3 in living cells using optical tweezers (2004)

Integrin receptors serve as both mechanical links and signal transduction mediators between the cell and its environment. Experimental evidence demonstrates that conformational changes and lateral clustering of the integrin proteins may affect their binding to ligands and regulate downstream cellular responses; however, experimental links between the structural and functional correlations of the ligand-receptor interactions are not yet elucidated. In the present report, we utilized optical tweezers to measure the dynamic binding between the snake venom rhodostomin, coated on a microparticle and functioned as a ligand, and the membrane receptor integrin alpha(IIb)beta(3) expressed on a Chinese Hamster Ovary (CHO) cell. A progressive increase of total binding affinity was found between the bead and CHO cell in the first 300 sec following optical tweezers-guided contact. Further analysis of the cumulative data revealed the presence of "unit binding force" presumably exerted by a single rhodostomin-integrin pair. Interestingly, two such units were found. Among the measurements of less total binding forces, presumably taken at the early stage of ligand-receptor interactions, a unit of 4.15 pN per molecule pair was derived. This unit force dropped to 2.54 pN per molecule pair toward the later stage of interactions when the total binding forces were relatively large. This stepped change of single molecule pair binding affinity was not found when mutant rhodostomin proteins were used as ligands (a single unit of 1.81 pN per pair was found). These results were interpreted along with the current knowledge about the conformational changes of integrins during the "molecule activation" process.
Dysglycemia in adults at risk for or living with non-insulin treated type 2 diabetes: Insights from continuous glucose monitoring (2021)

US Department of Agriculture (Grant #2018-33800-28404) and NSF PATHS-UP ERC (Award #1648451).