gebhart/patrepeval huggingface dataset:
Encuesta de conocimientos, actitudes y prácticas sobre dietas milagro en población española: estudio transversal “DiMilagro” (2021)

Introducción: La aparición de dietas milagro podría deberse a la dificultad de la población para modificar sus estilos de vida y conseguir la adherencia a intervenciones terapéuticas. El objetivo de este trabajo fue evaluar los conocimientos, actitudes y prácticas sobre dietas milagro en un panel de consumidores de características socio demográficas similares a la población española. Material y métodos: Estudio transversal con encuesta online de conocimientos, actitudes y prácticas no validada y elaborada según guías de FAO, en muestra de ambos sexos de 18 a 65 años. Resultados: Hubo 2.604 encuestas válidas (50% mujeres). La mayoría (57,9%) declaró conocer alguna característica de las dietas milagro y supo identificarlas (65,8%). El 90% cree que no funcionan y que sus efectos son principalmente negativos (82,6%). 487 personas (18,7%) declararon haber seguido una o varias dietas milagro, durante 15 días y más de 6 meses, tomado algún producto asociado (56%) que adquirieron en herboristerías (52%) y farmacias (30%), y creyeron percibir (57%, n=277) alguno de los efectos prometidos, aunque sólo a corto plazo, y el 33% creyó percibir algún efecto adverso de carácter leve. El 73,7% del total de la muestra declaró que las dietas milagro son un problema y el 78,6% que son peligrosas. El 82,1% no indicó sentirse vulnerable por la adopción de una dieta milagro. Conclusiones: El nivel de conocimiento sobre las dietas milagro en la población del estudio es medio, la mayoría las percibe como un problema, pero no se siente vulnerable ni con intención de seguir una dieta milagro. Sin embargo, el 22% de la muestra siguió algún tipo de dieta milagro, aunque solo el 18,7% lo reconoce. Es necesario nuevas investigaciones que exploren, en mayor profundidad, cómo el nivel conocimiento y actitud de la población frente a las dietas milagro se relaciona con la práctica.
Enhanced stability of SrRuO3 mixed oxide via monovalent doping in Sr1-xKxRuO3 for the oxygen evolution reaction (2022)

Ru mixed oxides are the most active catalysts for the oxygen evolution reaction (OER) in acid electrolyte. However, their stability is seriously compromised during the reaction. In this work we show that it is possible to enhance both OER activity and durability of SrRuO3 mixed oxide by the partial doping with K+ in Sr2+ sites. Sr1-xKxRuO3 perovskites (x = 0.00, 0.05, 0.10 and 0.20) have been synthesized by wet chemistry. The partial doping with K+ cations led to oxides with Ru atoms in a higher oxidation state. In addition, K-doping resulted in perovskites with slightly higher symmetry. The performance of the K-doped perovskites for the OER was assessed in acid electrolyte. Clearly, the K-doped materials, especially Sr0.80K0.20RuO3, display higher activity (lower E10) and significantly higher durability than the undoped sample SrRuO3. The results indicate that chemical modifications on Ru perovskites can be a suitable strategy to improve the stability of Ru phases during the OER.
Meningocerebrovascular amyloidosis associated with a novel transthyretin mis-sense mutation at codon 18 (TTRD 18G) (1996)

We describe a novel transthyretin mutation at codon 18 where Asp is replaced by Gly (D18G) in a Hungarian kindred. This mutation is associated with meningocerebrovascular amyloidosis, producing dementia, ataxia, and spasticity. Fifty different transthyretin mutations are related to amyloid deposition, typically producing a peripheral neuropathy or cardiac dysfunction. These symptoms are absent in this family. Up to now, amyloid-beta (A beta), cystatin C, and prion proteins have been known to be deposited as amyloid in the brain, leading to stroke or dementia. With this report we establish that transthyretin amyloid deposition can also produce central nervous system dysfunction as the major clinical symptom.
Chemistry and Biology of the 2.beta.-Alkyl-3.beta.-phenyl Analogs of Cocaine: Subnanomolar Affinity Ligands That Suggest a New Pharmacophore Model at the C-2 Position (1995)

A series of 2 beta-alkyl-3 beta-phenyltropanes (i.e., the 2 beta-alkyl analogues of the WIN series) were prepared as analogues of cocaine and tested for their ability to displace [3H]mazindol binding and to inhibit high-affinity dopamine uptake into striatal nerve endings (synaptosomes). These 2 beta-alkyl analogues were readily prepared in optically pure form starting from cocaine by proceeding through the 2 beta-phenyl-bearing aldehyde 6 as a key intermediate. Wittig reaction of 6 with the appropriate phosphorane and hydrogenation delivered the final products. All new compounds with the exception of 8e were found to exhibit nanomolar or subnanomolar affinity for the cocaine binding site in the rat striatum. These results are in apparent opposition to the binding model previously proposed which suggests a hydrogen bond donor-acceptor interaction to be present in the vicinity of the C-2 substituent. Taken together with our previous reports and recent findings from other laboratories, we suggest a new pharmacophore model in which 2 beta-substituents lacking H-bond acceptors enhance affinity to the binding site through hydrophobic interactions. The new SAR data contained herein may be relevant to the design of possible cocaine antagonists.
Effect of Physical defect on schmoos in CMOS DSM technologies (2008)

International audience
Optical synchronization of a 2 μm Ho:fiber oscillator and phase-noise analysis (2022)

A 2 μm Holmium oscillator, frequency-converted to 1025 nm, and a 1030 nm oscillator locked to an RF reference are synchronized optically. The timing jitter measured on the 2 μm oscillator is reduced to 19 fs.
Binder-Free, Thin-Film Ceramic-Coated Separators for Improved Safety of Lithium-Ion Batteries (2021)

Separators play a crucial role in ensuring the safety of lithium-ion batteries (LIBs). Commercial polyolefin-based separators such as polyethylene (PE) still possess serious safety risks under abuse conditions because of their poor thermal stability. In this work, a novel type of binder-free, thin ceramic-coated separators with superior safety characteristics is demonstrated. A thin layer of alumina (Al<sub>2</sub>O<sub>3</sub>) is coated on commercial PE separators using the electron-beam physical vapor deposition (EB-PVD) technique. Scanning electron microscopy (SEM), contact angle, impedance spectroscopy, and adhesion test techniques were employed to evaluate structure-property correlations. When compared to commercial slurry-coated separators, the EB-PVD-coated separators display (i) higher thermal stability, (ii) stronger ceramic-polymer adhesion, and (iii) competitive electrochemical performance of full LIB cells. Thermal stability, in terms of improved shutdown and breakdown characteristics of the separator, was studied using the in situ impedance technique up to 190 °C. In addition, the improved adhesion of the ceramic layer deposited on the PE separator was studied following the tape adhesion strength test. We prove that the thin (binder-free) ceramic layer coated by EB-PVD is far more effective in improving separator safety than those made using the conventional thick slurry coating.
Resonant exceptional-point gyroscopes (2021)

Operating an optical device at an EP causes small perturbations  applied to the device’s optical path length to produce a greatly enhanced splitting of resonance frequencies due to the splitting being proportional to  at the EP, instead of  as for conventional devices. For increasingly small  , the EP splitting can therefore be larger by several orders of magnitude by operating sufficiently close to the EP. This enhanced splitting has drawn great interest recently, in particular for the potential to miniaturize the optical gyroscope. However, a small but growing number of publications claim that EP sensors may not achieve a proportionally larger signal-to-noise ratio once the full readout system and noise is accounted for. Many different EP sensors have been proposed, some as passive resonators, others as resonators with internal gain operated either below or above lasing threshold. Each sensor class may use a different readout system to measure the splitting and is therefore subject to different noise, but the recent trend has been that once noise and readout system have been accounted for, the enhanced  response cancels out and a signal-to-noise ratio proportional to  is achieved. Despite this cancellation, enhanced precision in EP sensors has still been predicted, although there is disagreement in whether the enhancement arises from the EP or another aspect of the sensor’s architecture, such as the gain. In this paper, we demonstrate through simulations that the EP in two-coupled-mode resonant (below lasing threshold) gyroscopes plays no role in enhancing the signal-to-noise ratio. An all-passive EP gyro is simulated in the limits of shot noise and detector noise to show that in either of these noise limits, no improvement in SNR over the equivalent single-ring gyro is possible. One of the rings is then given gain to show that a large enhancement in detectornoise- limited SNR (~2400 fold) arises, but close proximity to the EP is not necessary to maximize this enhancement; the enhancement is actually significantly larger when the sensor is detuned from the EP. This gain-loss gyro is then compared to a single-ring gyro with gain to show that large sensitivity enhancements are possible in both architectures because the gain compensates the resonator loss, resulting in a narrowing of the resonance linewidth and a greater response to a rotation, but the coupled-ring gyro exhibits a much greater stability to gain fluctuations.
Hierarchical Behavior Model for Multi-Agent System with Evasion Capabilities and Dynamic Memory (2020)

The behavior of an agent may be simple or complex depending on its role. Behavioral simulation using agents can have multiple approaches that have different advantages and disadvantages. By combining different behaviors in a hierarchical model, situational inefficiencies can be compensated. This paper proposes a behavioral hierarchy model that combines different mechanisms in behavior plans. The study simulates the social behavior in an office environment during an emergency using collision avoidance, negotiation, conflict solution, and path-planning mechanisms in the same multi-agent model to find their effects and the efficiency of the combinational setups. Independent agents were designed to have memory expansion, pathfinding, and searching capabilities, and the ability to exchange information among themselves and perform evasive actions to find a way out of congestion and conflict. The designed model allows us to modify the behavioral hierarchy and action order of agents during evacuation scenarios. Moreover, each agent behavior can be enabled or disabled separately. The effects of these capabilities on escape performance were measured in terms of time required for evacuation and evacuation ratio. Test results prove that all mechanisms in the proposed model have characteristics that fit each other well in situations where different hierarchies are needed. Dynamic memory management (DMM), together with a hierarchical behavior plan, achieved a performance improvement of 23.14% in escape time without providing agents with any initial environmental information.
Fault Detection And Identification With Application To Advanced Vehicle Control Systems (1995)

In this report, a preliminary design of a health monitoring system for automated vehicles is developed and results of tests in a high-fidelity nonlinear simulation are reported. Two car models are described: low- dimensional linear models for fault detection filter design and high fidelity nonlinear model is used for evaluation and to obtain the linear models used for design. The faults and the fault detection filters and system are then described. An evaluation of the performance of the fault detection filters in a nonlinear simulation are presented. A fault detection filter residual processing system, using a neural network, is then described.
Silicon photonics optical frequency synthesizer - SPOFS (2019)

We demonstrate a silicon photonics optical frequency synthesizer (SPOFS). The frequency instability obtained in the telecom band is 1×10−12 at 1s level, comparable to a bench-top commercial optical frequency synthesizer system.
Temperature insensitive smart optical strain sensor (2000)

An optical strain gage, employing a hollow polyimide-coated glass capillary tube, is currently under development. The capillary tube serves as a waveguide, in which an optical signal is attenuated in an amount proportional to applied bending strain. The capillary is incorporated into an optical fiber link which acts as both the source of signal and as the return path to a photodiode detector. The inherent compatibility of this optical strain sensor with fiber optic telecommunication systems makes it amenable for incorporation into intelligent systems for the continuous monitoring and damage assessment of bridges, highways, piers, airframes, and buildings. By applying various thin films to the interior and/or exterior surfaces of the waveguide, the strain gage can be optimized for specific strain ranges. This optical strain sensor exhibits advantages in comparison to commercially available metal foil (resistance) strain gages, including gage factors 100 times larger and temperature insensitivity for operating temperatures ranging from -25 °C to +51 °C.
Video multicast in (large) local area networks (2003)

We consider the problem of distributing high-quality video signals over IP multicast in large local area networks (LANs), under realtime delay constraints, and with software-only processing. In a large LAN (such as the network of a university campus, or the network of a large company), the source of channel heterogeneity that the video communications system must cope with is not that of different bandwidth constraints available to each receiver, but it is essentially variations in the available CPU power that each receiver has in order to decode the incoming signal. We propose a new architecture for a video multicast system, present the design of the different components of this system, and show results obtained in a real implementation. Our feeds consist of video encoded at about 3 Mbits/sec and 16 frames/sec, capable of tolerating the loss of about 300 Kbits/sec worth of data. Decoding is performed on Linux PCs, and the quality of our reconstructed signals degrades gracefully with the speed of the CPU on which the receiver runs.
Dual-color emitting quantum-dot-quantum-well CdSe-ZnS heteronanocrystals hybridized on InGaN∕GaN light emitting diodes for high-quality white light generation (2008)

We report white light generation by hybridizing green-red emitting (CdSe)ZnS∕CdSe (core)shell/shell quantum-dot-quantum-well heteronanocrystals on blue InGaN∕GaN light emitting diodes with the photometric properties of tristimulus coordinates (x,y)=(0.36,0.30), luminous efficacy of optical radiation LE=278lm∕W, correlated color temperature CCT=3929K, and color-rendering index CRI=75.1. We present the photometric analysis and the quantum mechanical design of these dual-color emitting heteronanocrystals synthesized to achieve high-quality white light when hybridized on light emitting diodes. Using such multicolor emitting heteronanocrystals facilitates simple device implementation while providing good photometric properties.
Nickel catalysed asymmetric cycloisomerisation of diethyl diallylmalonate (2005)

Cationic nickel catalysts with monodentate phosphoramidites and Wilke's azaphospholene as ligands are highly regio- and enantioselective catalysts for the cycloisomerisation of diethyl diallylmalonate.
Ikaros Is a Frequently Affected Hematopoietic Differentiation Factor in Pediatric Relapse-Prone Precursor B-Cell Acute Lymphoblastic Leukemia (2008)

Abstract Relapse is the most common cause of treatment failure in childhood acute lymphoblastic leukemia (ALL), and is difficult to predict in the majority of cases. Here, we performed genome-wide copy number profiling of 34 paired diagnosis-relapse samples from children diagnosed with precursor-B cell ALL. The majority of the copy number abnormalities were preserved between matched diagnosis and relapse samples, but lesions unique in either of the two samples were observed in 82% of the cases. In 68% of the cases lesions present at diagnosis were no longer detected in relapse samples (including recurrent lesions affecting the PAX5, CDKN2A, and EBF genes), indicating that these lesions were secondary events, absent in the original therapy-resistant progenitor clone. Deletions in the IKZF1 gene encoding the hematopoietic differentiation factor Ikaros were observed in 38% of the diagnosis samples, which is &amp;gt;6-fold the amount detected in an unselected group of pediatric ALLs. Tiling-resolution oligo arrays were used to map the breakpoints, which demonstrated that the protein-coding exons 3–6, encoding the DNA-binding Zn-finger domains, were most commonly deleted. Sequence analysis revealed that point mutations in IKZF1 do occur but are less frequent. Furthermore, IKZF1 deletions were always preserved in relapse. Together, we conclude that IKZF1 deletions are frequent events in therapy-resistant clones of relapse-prone pediatric precursor B-ALL.
Holt's exponential smoothing method for forecasting silver prices (2016)

In this paper, it is suggested that for forecasting the silver prices, the optimum technique is the Holt's exponential smoothing method. For getting this conclusion we have collected the data on average monthly silver prices for period of 7 years from Jan 2008 to Dec 2014 obtained from World Silver Council and applied Single Exponential Smoothing Method, Holt's Exponential Smoothing Method and Auto Regressive Moving Average (ARMA) Methods. By comparing the above techniques basing on measures of accuracy say, Mean Absolute Percent Error(MAPE) measure, it was found that MAPE is minimum for Holt's method. Using this method to forecast the silver prices for the succeeding period.
Abortive Lytic Reactivation of KSHV in CBF1/CSL Deficient Human B Cell Lines (2013)

Since Kaposi's sarcoma associated herpesvirus (KSHV) establishes a persistent infection in human B cells, B cells are a critical compartment for viral pathogenesis. RTA, the replication and transcription activator of KSHV, can either directly bind to DNA or use cellular DNA binding factors including CBF1/CSL as DNA adaptors. In addition, the viral factors LANA1 and vIRF4 are known to bind to CBF1/CSL and modulate RTA activity. To analyze the contribution of CBF1/CSL to reactivation in human B cells, we have successfully infected DG75 and DG75 CBF1/CSL knock-out cell lines with recombinant KSHV.219 and selected for viral maintenance by selective medium. Both lines maintained the virus irrespective of their CBF1/CSL status. Viral reactivation could be initiated in both B cell lines but viral genome replication was attenuated in CBF1/CSL deficient lines, which also failed to produce detectable levels of infectious virus. Induction of immediate early, early and late viral genes was impaired in CBF1/CSL deficient cells at multiple stages of the reactivation process but could be restored to wild-type levels by reintroduction of CBF1/CSL. To identify additional viral RTA target genes, which are directly controlled by CBF1/CSL, we analyzed promoters of a selected subset of viral genes. We show that the induction of the late viral genes ORF29a and ORF65 by RTA is strongly enhanced by CBF1/CSL. Orthologs of ORF29a in other herpesviruses are part of the terminase complex required for viral packaging. ORF65 encodes the small capsid protein essential for capsid shell assembly. Our study demonstrates for the first time that in human B cells viral replication can be initiated in the absence of CBF1/CSL but the reactivation process is severely attenuated at all stages and does not lead to virion production. Thus, CBF1/CSL acts as a global hub which is used by the virus to coordinate the lytic cascade.
Single-Cell Mass Spectrometry of Metabolites Extracted from Live Cells by Fluidic Force Microscopy (2017)

Single-cell metabolite analysis provides valuable information on cellular function and response to external stimuli. While recent advances in mass spectrometry reached the sensitivity required to investigate metabolites in single cells, current methods commonly isolate and sacrifice cells, inflicting a perturbed state and preventing complementary analyses. Here, we propose a two-step approach that combines nondestructive and quantitative withdrawal of intracellular fluid with subpicoliter resolution using fluidic force microscopy, followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The developed method enabled the detection and identification of 20 metabolites recovered from the cytoplasm of individual HeLa cells. The approach was further validated in <sup>13</sup>C-glucose feeding experiments, which showed incorporation of labeled carbon atoms into different metabolites. Metabolite sampling, followed by mass spectrometry measurements, enabled the preservation of the physiological context and the viability of the analyzed cell, providing opportunities for complementary analyses of the cell before, during, and after metabolite analysis.
Human immunoglobulins are transported to HCMV viral envelope by viral Fc gamma receptors-dependent and independent mechanisms (2023)

Human cytomegaloviruses (HCMVs) employ many different mechanisms to escape and subvert the host immune system, including expression of the viral IgG Fcγ receptors (vFcγRs) <i>RL11</i> (gp34), <i>RL12</i> (gp95), <i>RL13</i> (gpRL13), and <i>UL119</i> (gp68) gene products. The role of vFcγRs in HCMV pathogenesis has been reported to operate in infected cells by interfering with IgG-mediated effector functions. We found that gp34 and gp68 are envelope proteins that bind and internalize human IgGs on the surface of infected cells. Internalized IgGs are then transported on the envelope of viral particles in a vFcR-dependent mechanism. This mechanism is also responsible for the incorporation on the virions of the anti-gH neutralizing antibody MSL-109. Intriguingly, we show that gp68 is responsible for MSL-109 incorporation, but it is dispensable for other anti-HCMV antibodies that do not need this function to be transported on mature virions. HCMV-infected cells grown in presence of anti-HCMV monoclonal antibodies generate a viral progeny still infective and possible to be neutralized. This is the first example of a virus carrying neutralizing IgGs on its surface and their possible role is discussed.
Acid Sphingomyelinase Controls Early Phases of Skeletal Muscle Regeneration by Shaping the Macrophage Phenotype (2021)

Skeletal muscle regeneration is a complex process involving crosstalk between immune cells and myogenic precursor cells, i.e., satellite cells. In this scenario, macrophage recruitment in damaged muscles is a mandatory step for tissue repair since pro-inflammatory M1 macrophages promote the activation of satellite cells, stimulating their proliferation and then, after switching into anti-inflammatory M2 macrophages, they prompt satellite cells' differentiation into myotubes and resolve inflammation. Here, we show that acid sphingomyelinase (ASMase), a key enzyme in sphingolipid metabolism, is activated after skeletal muscle injury induced in vivo by the injection of cardiotoxin. ASMase ablation shortens the early phases of skeletal muscle regeneration without affecting satellite cell behavior. Of interest, ASMase regulates the balance between M1 and M2 macrophages in the injured muscles so that the absence of the enzyme reduces inflammation. The analysis of macrophage populations indicates that these events depend on the altered polarization of M1 macrophages towards an M2 phenotype. Our results unravel a novel role of ASMase in regulating immune response during muscle regeneration/repair and suggest ASMase as a supplemental therapeutic target in conditions of redundant inflammation that impairs muscle recovery.