gebhart/patrepeval huggingface dataset:
Evaluation of Autoantibody Binding to Cardiac Tissue in Multisystem Inflammatory Syndrome in Children and COVID-19 Vaccination–Induced Myocarditis (2023)

This etiological diagnostic study found no evidence of antibodies from MIS-C and COVID-19 vaccine myocarditis serum binding cardiac tissue, suggesting that the cardiac pathology in both conditions is unlikely to be driven by direct anticardiac antibody-mediated mechanisms.
Polymer-Encapsulated A<I>β</I> Peptide Fragments as an Oligomeric-Specific Vaccine for Alzheimer's Disease (2016)

Vaccination is regarded as one of the most cost-effective and reliable methods for combating disease. We have developed a new method for an oligomeric Aβ-specific AD vaccination using polymer micelle-encapsulated peptide fragments, which overcome many problems of vaccination associated with the direct use of the Aβ1–42 peptide. We studied different encapsulated forms of shortened Aβ peptides with and without the entire T cell epitope in an APP/PS1 mouse model. After two inoculations with encapsulated Aβ fragments, antibodies were produced in all mice with antibody titer greater than 1:12,800. No anti-polymer antibodies were detected after five inoculations, and none of the injected mice showed any adverse effects throughout experimentation. Anti-Aβ antibodies from our polymer-encapsulated vaccine were able to bind to A plaques in the brain of our mice, and were able to specifically recognize oligomeric Aβ. Our results suggest that the safety and efficacy issues previously encountered in other Aβ vaccination trials may be successfully addressed by using micelle-encapsulated peptides. These shorter Aβ fragments are also easier to synthesize and more cost-effective than the highly hydrophobic full-length Aβ1–42 peptide.
Thrombocytopenia after immunization of Canadian children, 1992 to 2001 (2003)

Thrombocytopenia associated with routine immunization of children is rare and usually benign, resolving within 1 month in most children.
Thermally Stable Nonlinear Optical Films by Alternating Polyelectrolyte Deposition on Hydrophobic Substrates (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThermally Stable Nonlinear Optical Films by Alternating Polyelectrolyte Deposition on Hydrophobic SubstratesM. Joseph Roberts, Geoffrey A. Lindsay, Warren N. Herman, and Kenneth J. WynneView Author Information Naval Air Warfare Center Weapons Division Chemistry and Materials Branch Code 4B2200D, 1 Administration Circle China Lake, California 93555 Naval Air Warfare Center Aircraft Division Electrooptic Sensors Branch 48110 Shaw Road Unit 5 Patuxent River, Maryland 20657 Office of Naval Research 800 North Quincy Street Arlington, Virginia 22217 Cite this: J. Am. Chem. Soc. 1998, 120, 43, 11202–11203Publication Date (Web):October 16, 1998Publication History Received29 June 1998Published online16 October 1998Published inissue 1 November 1998https://pubs.acs.org/doi/10.1021/ja9822613https://doi.org/10.1021/ja9822613rapid-communicationACS PublicationsCopyright © Not subject to U.S. Copyright. Published 1998 American Chemical SocietyRequest reuse permissionsArticle Views247Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Deposition,Hydrophobicity,Nonlinear optics,Solution chemistry,Vesicles Get e-Alerts
Optimum Tolerances Synthesis for Globoidal Cam Mechanisms. (2002)

This research proposes an organized process to analyze the transmission error and to synthesize the tolerances for globoidal cam mechanisms. First, the geometric mathematical models of the cam surface are determined by the conjugating theory. Based on these models and Taylor series, the output variable is expressed by sensitivity factors about design variables and the differences from the random and the mean of them respectively. And, the transmission error is also calculated according to the practical coordinate data on the manufactured cam surface and misalignments. By applying statistics and cost-tolerance function, the objective function subjected to the variance of the tolerances is established. The Lagrange multiplier is then involved to synthesize the optimum tolerances with minimizing manufacturing cost. This process is verified in an industrial example finally.
Long Term Ablation of Protein Kinase A (PKA)-mediated Cardiac Troponin I Phosphorylation Leads to Excitation-Contraction Uncoupling and Diastolic Dysfunction in a Knock-in Mouse Model of Hypertrophic Cardiomyopathy (2014)

The cardiac troponin I (cTnI) R21C (cTnI-R21C) mutation has been linked to hypertrophic cardiomyopathy and renders cTnI incapable of phosphorylation by PKA in vivo. Echocardiographic imaging of homozygous knock-in mice expressing the cTnI-R21C mutation shows that they develop hypertrophy after 12 months of age and have abnormal diastolic function that is characterized by longer filling times and impaired relaxation. Electrocardiographic analyses show that older R21C mice have elevated heart rates and reduced cardiovagal tone. Cardiac myocytes isolated from older R21C mice demonstrate that in the presence of isoproterenol, significant delays in Ca(2+) decay and sarcomere relaxation occur that are not present at 6 months of age. Although isoproterenol and stepwise increases in stimulation frequency accelerate Ca(2+)-transient and sarcomere shortening kinetics in R21C myocytes from older mice, they are unable to attain the corresponding WT values. When R21C myocytes from older mice are treated with isoproterenol, evidence of excitation-contraction uncoupling is indicated by an elevation in diastolic calcium that is frequency-dissociated and not coupled to shorter diastolic sarcomere lengths. Myocytes from older mice have smaller Ca(2+) transient amplitudes (2.3-fold) that are associated with reductions (2.9-fold) in sarcoplasmic reticulum Ca(2+) content. This abnormal Ca(2+) handling within the cell may be attributed to a reduction (2.4-fold) in calsequestrin expression in conjunction with an up-regulation (1.5-fold) of Na(+)-Ca(2+) exchanger. Incubation of permeabilized cardiac fibers from R21C mice with PKA confirmed that the mutation prevents facilitation of mechanical relaxation. Altogether, these results indicate that the inability to enhance myofilament relaxation through cTnI phosphorylation predisposes the heart to abnormal diastolic function, reduced accessibility of cardiac reserves, dysautonomia, and hypertrophy.
Automated motion artifact removal for intravital microscopy, without a priori information (2014)

Intravital fluorescence microscopy, through extended penetration depth and imaging resolution, provides the ability to image at cellular and subcellular resolution in live animals, presenting an opportunity for new insights into in vivo biology. Unfortunately, physiological induced motion components due to respiration and cardiac activity are major sources of image artifacts and impose severe limitations on the effective imaging resolution that can be ultimately achieved in vivo. Here we present a novel imaging methodology capable of automatically removing motion artifacts during intravital microscopy imaging of organs and orthotopic tumors. The method is universally applicable to different laser scanning modalities including confocal and multiphoton microscopy and offers artifact free reconstructions independent of the physiological motion source and imaged organ. The methodology, which is based on raw data acquisition followed by image processing, is here demonstrated for both cardiac and respiratory motion compensation in mice heart, kidney, liver, pancreas and dorsal window chamber.
Effect of Amphotericin B on Capsule and Cell Size inCryptococcus neoformansduring Murine Infection (2005)

Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis.
Gaussian beams and Legendre polynomials as invariants of the time reversal operator for a large rigid cylinder (2006)

The DORT method (French acronym for decomposition of the time reversal operator) is an active remote sensing technique using an array of antennas for the detection and localization of scatterers. This method is based on the singular value decomposition of the interelement response matrix. In this paper an analytical expression of the singular vectors due to the reflection from a large rigid cylinder is provided. Depending on the array aperture, two asymptotic regimes are described. It is shown that the singular vectors correspond to Hermite-Gaussian modes for large apertures and Legendre polynomials for small ones. Using perturbation theory, the corresponding singular values are deduced. Theoretical predictions are in good agreement with experimental results.
Highly Effective Control of an AIDS Virus Challenge in Macaques by Using Vesicular Stomatitis Virus and Modified Vaccinia Virus Ankara Vaccine Vectors in a Single-Boost Protocol (2004)

Previous studies have shown that vaccination and boosting of rhesus macaques with attenuated vesicular stomatitis virus (VSV) vectors encoding Env and Gag proteins of simian immunodeficiency virus-human immunodeficiency virus (SHIV) hybrid viruses protect rhesus macaques from AIDS after challenge with the highly pathogenic SHIV 89.6P (23). In the present study, we compared the effectiveness of a single prime-boost protocol consisting of VSV vectors expressing SHIV Env, Gag, and Pol proteins to that of a protocol consisting of a VSV vector prime followed with a single boost with modified vaccinia virus Ankara (MVA) expressing the same SHIV proteins. After challenge with SHIV 89.6P, MVA-boosted animals controlled peak challenge viral loads to less than 2 x 10(6) copies/ml (a level significantly lower than that seen with VSV-boosted animals and lower than those reported for other vaccine studies employing the same challenge). MVA-boosted animals have shown excellent preservation of CD4(+) T cells, while two of four VSV-boosted animals have shown significant loss of CD4(+) T cells. The improved protection in MVA-boosted animals correlates with trends toward stronger prechallenge CD8(+)-T-cell responses to SHIV antigens and stronger postchallenge SHIV-neutralizing antibody production.
Wellens syndrome as an independent predictor of in-hospital cardiovascular complications (2022)

The presence of Wellens Syndrome is independently associated with the appearance of cardiac complications during hospitalisation.Key pointsSW is now known to be a relatively frequent presentation of ACS, not addressed in depth in clinical practice guidelines for NSTEACS. This syndrome is generally caused by a severe ADA occlusion that, if not adequately treated, could evolve into a large infarction. According to the results of the different series published, the incidence of cardiovascular risk factors in SW is similar to other forms of presentation of ischaemic heart disease.At present, the exact relationship between the main cardiovascular risk factors and SW is unknown; in addition to the possible associations of this syndrome with in-hospital cardiovascular complications and its value as a predictor of the occurrence of cardiac complications, elements that are included in the results of the present study.
Themoreversible Cross-Linking Rubber Using Supramolecular Hydrogen-Bonding Networks (2001)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTThemoreversible Cross-Linking Rubber Using Supramolecular Hydrogen-Bonding NetworksKeisuke Chino and Makoto AshiuraView Author Information Research & Development Center, The Yokohama Rubber, Co. Ltd., 2-1 Oiwake, Hiratsuka, Kanagawa 254-8601, Japan Cite this: Macromolecules 2001, 34, 26, 9201–9204Publication Date (Web):November 10, 2001Publication History Received17 July 2001Published online10 November 2001Published inissue 1 December 2001https://pubs.acs.org/doi/10.1021/ma011253vhttps://doi.org/10.1021/ma011253vbrief-reportACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views3333Altmetric-Citations163LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Addition reactions,Biopolymers,Noncovalent interactions,Nucleic acid structure,Polymers Get e-Alerts
Recovery and accumulation of ion irradiation damage leading to dose rate dependence in GaAs (2020)

Abstract Competing dynamics was analyzed for generation, recovery and accumulation of ion irradiation damage using three methods including He-ion channeling backscattering. The in situ tracing of electrical conductance after pulsed 100 keV proton irradiations at 23 °C–92 °C revealed that the subsequent recovery process was a second-order reaction with an activation energy of 0.74 eV in n -type and 0.31 eV in p -type epitaxial layers arising from long-range migration of both Ga and As interstitials. The amorphized depth by pulsed irradiations exhibited that the recovery was suppressed by the incidence of two ions within a lateral separation, which increased from ∼5 to ∼20 nm with the ion mass for 80 keV Ne + , 150 keV Ar + , and 300 keV Kr + ions of an identical projected range, 115 nm. From the comparison with ion-collision simulations, it was concluded that if two collision cascades overlap before the recovery, it enhances interstitial clustering while suppressing the annihilation and causes the dose rate dependence.
Er-doped amorphous and crystalline Al{sub 2}O{sub 3} and La{sub 2}O{sub 3} films grown with low energy ions from an ECR plasma (1996)

The effects of low energy ions from a biased electron cyclotron resonance plasma during growth of Al{sub 2}O{sub 3} and La{sub 2}O{sub 3} are used to modify the density and crystalline quality of these oxide films. The type of phase formed for Al{sub 2}O{sub 3} is varied with the ion-assisted growth from amorphous to crystalline {gamma}-Al{sub 2}O{sub 3}. The photoluminescence (PL) properties of different Er-doped Al- and La-oxide phases are examined and through comparison of the PL spectra, the local environment of Er in these oxide materials is discussed.
Eradication of Borrelia Burgdoferi in vitro using Chlorine Dioxide: A Novel Approach (2022)

Lyme disease, which is caused by the spirochete Borrelia burgdorferi is the most prevalent tick-borne illness in the world today and has grown into a major public health problem during the last decade, irrelevant to decades of efforts from various health professionals. The conventional treatment for Lyme disease is the use of a variety of antibiotics, but relapse often occurs when antibiotics are discontinued. There are several reasons why this relapse may occur, given that B. burgdorferi is a pleomorphic microorganism that can convert from vegetative spirochetes to a variety of different round bodies and biofilm colonies. Therefore, there is an urgent need for novel approaches that can eliminate all these different morphologies. This has challenged many health practitioners around the world, not to mention the suffering of many afflicted people. In this study, Chlorine dioxide (CD) at different concentrations was tested for its effectiveness in vitro against B. burgdorferi using combined fluorescent and darkfield microscopy with Live-or-Dye staining methods. Our experiments demonstrated that it is possible to completely eradicate all forms of B. burgdorferi at specific concentrations of Chlorine dioxide. Our extensive research has shown that Chlorine dioxide can be used for the eradication of B. burgdorferi morphologies. At certain concentrations of chlorine dioxide above 2 ppm the Borrelia morphologies appear to be eradicated as there is no motility of either spirochetes or round bodies, only biofilms visible. However, incubating again for another 7 days resulted in the Borrelia being motile again as they come out of the biofilms. We, therefore, decided to conduct each experiment with what we termed the Regrowth Kill Test (RKT) by incubating the initial sample with the CD in an incubator at 37 degrees centigrade in the Campypack for 7-days. It appeared that the biofilms that are quickly formed as soon as the CD is added in the initial experiment, broke up and released small spirochetes and round bodies of different morphologies. After numerous RKT experiments, it was determined that the concentration that resulted in a near complete disinfection of the spirochetes as well as round bodies was 30 ppm CD.
Hardware Mechanisms for Distributed Dynamic Software Analysis. (2012)

The complexity of modern software makes it difficult to ship correct programs. Errors can cost money and lives, so developers often use automated software analysis tools to hunt for bugs. By automatically analyzing a program's runtime operation, dynamic analysis tools can find subtle errors that would normally escape the notice of even careful human testers. These dynamic analyses are more likely to find errors if they observe the program under numerous and varied runtime situations, so, ideally, users would analyze programs as they run them. Regrettably, these tests cause orders-of-magnitude slowdowns, which few users would tolerate. This dissertation presents methods of accelerating dynamic software analyses in order to distribute these trials to users. It begins by observing that the overhead that any individual observes can be lowered by allowing each user to analyze a small, random sample of the program's operations. It then describes a sampling mechanism for dynamic dataflow analyses that only requires access to the virtual memory system. Other dynamic software analyses cannot use this technique, so the remainder of this dissertation focuses on novel hardware-based acceleration mechanisms. The first, Testudo, allows faster and more accurate dataflow analysis sampling by storing meta-data in an on-chip cache and stochastically removing these values whenever it overflows. Next, a method for performing demand-driven data race detection using existing hardware performance counters is detailed. These counters make inter-cache sharing events visible to software, allowing the data race detector to be enabled only when needed. Finally, fine-grained memory monitoring is a crucial for every analysis studied in this work. This dissertation closes by examining a hardware mechanism for allowing unlimited fine-grained watchpoints, which can be used to reduce the overheads of many analyses. In total, this dissertation demonstrates that hardware designers can play a role in mitigating software bugs, as many of the acceleration mechanisms explored in this work require hardware support in one form or another. Taken together, these works represent a step forward for accelerating dynamic software analyses and distributing them to end-users.
Direct detection antenna-coupled mmW sensors for the detection of explosive vapors (2007)

The low vapor pressure and concentration of explosive such as TNT and RDX pose significant problems for the detection of explosive vapors in the mmW bands. For the positive identification of explosive vapors using an uncooled passive mmW imaging spectrometer with a low false alarm rate (FAR) requires an unprecedented sensitivity of <150 fW. We report on the recent development of a novel uncooled mmW antenna-coupled direct detector, which shows promise of meeting this requirement.
ChemInform Abstract: Phosphinic Acid Inhibitors of 3‐Hydroxy‐3‐methylglutaryl Coenzyme A Reductase. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Regulation by glucocorticoids and osmolality of expression of ROMK (Kir 1.1), the apical K channel of thick ascending limb (2003)

Mechanisms of regulation of ROMK channel mRNA and protein expression in medullary thick ascending limb (MTAL) were assessed in rat MTAL fragments incubated for 7 h. ROMK mRNA was quantified by quantitative RT-PCR and ROMK protein by immunoblotting analysis of crude membranes. Medium hyperosmolality (450 mosmol/kgH(2)O; NaCl plus urea added to isoosmotic medium) increased ROMK mRNA (P < 0.04) and protein (P < 0.006), and 10 nM dexamethasone also increased ROMK mRNA (P < 0.02). Hyperosmolality and dexamethasone had no additive effects on ROMK mRNA. NaCl alone, but not urea or mannitol, reproduced the hyperosmolality effect on ROMK mRNA. 1-Deamino-(8-d-arginine) vasopressin (1 nM) or 0.5 mM 8-bromo-cAMP had no effect per se on ROMK mRNA and protein. However, 8-bromo-cAMP abolished the stimulatory effect of dexamethasone on ROMK mRNA in the isoosmotic but not in the hyperosmotic medium (P < 0.004). In in vivo studies, the abundance of ROMK protein and mRNA increased in adrenalectomized (ADX) rats infused with dexamethasone compared with ADX rats (P < 0.02). These results establish glucocorticoids and medium NaCl concentration as direct regulators of MTAL ROMK mRNA and protein expression, which may be modulated by cAMP-dependent factors.