gebhart/patrepeval huggingface dataset:
On using partial supervision for text categorization (2004)

We discuss the merits of building text categorization systems by using supervised clustering techniques. Traditional approaches for document classification on a predefined set of classes are often unable to provide sufficient accuracy because of the difficulty of fitting a manually categorized collection of documents in a given classification model. This is especially the case for heterogeneous collections of Web documents which have varying styles, vocabulary, and authorship. Hence, we investigate the use of clustering in order to create the set of categories and its use for classification of documents. Completely unsupervised clustering has the disadvantage that it has difficulty in isolating sufficiently fine-grained classes of documents relating to a coherent subject matter. We use the information from a preexisting taxonomy in order to supervise the creation of a set of related clusters, though with some freedom in defining and creating the classes. We show that the advantage of using partially supervised clustering is that it is possible to have some control over the range of subjects that one would like the categorization system to address, but with a precise mathematical definition of how each category is defined. An extremely effective way then to categorize documents is to use this a priori knowledge of the definition of each category. We also discuss a new technique to help the classifier distinguish better among closely related clusters.
Synthesis of Soluble Host Materials for Highly Efficient Red Phosphorescent Organic Light-Emitting Diodes (2016)

New soluble host materials with benzocarbazole and triphenyltriazine moieties, 11-[3-(4,6-diphenyl-[1,3,5]triazin-2-yl)-phenyl]-11H-benzo[a]carbazole and 11-[3′-(4,6-diphenyl-[1,3,5]triazin-2-yl)-biphenyl-4-yl]-11H-benzo[a]carbazole, were synthesized for highly efficient red phosphorescent organic light-emitting diodes (PHOLED). Hole-transporting benzocarbazole moiety and electron transporting triphenyltriazine moiety, which are severely twisted each other enhance the solubility of those materials in common organic solvent. The improved solubility from this molecular design could be due to a reduced π–π stacking interaction, which gives a very uniform film morphology after spin coating of those materials. As a result, we obtained highly efficient soluble PHOLEDs combined with an evaporated blue common layer structure. The resultant red PHOLED exhibited the maximum current efficiency as well as external quantum efficiency values up to 23.7 cd/A and 19.0%.
Superfocusing terahertz waves below λ/250 using plasmonic parallel-plate waveguides (2010)

We experimentally demonstrate complete two-dimensional (2-D) confinement of terahertz (THz) energy in finite-width parallel-plate waveguides, defying conventional wisdom in the century-old field of microwave waveguide technology. We find that the degree of energy confinement increases exponentially with decreasing plate separation. We propose that this 2-D confinement is mediated by the mutual coupling of plasmonic edge modes, analogous to that observed in slot waveguides at optical wavelengths. By adiabatically tapering the width and the separation, we focus THz waves down to a size of 10 microm (approximately lambda/260) by 18 microm ( approximately lambda/145), which corresponds to a mode area of only 2.6 x 10(-5) lambda(2).
Analog‐ESD Signal Pin Co‐synthesis (2014)

This chapter addresses analog and ESD signal pin cosynthesis that introduces usage of interdigitated layout and common centroid concepts to provide ideal matching, low capacitance, and small area in differential signal pins. Using interdigitated designs, the parasitic elements are utilized for signal pin-to-signal pin ESD protection. In conclusion, the issue of common centroid design of ESD protection networks which integrates signal pin-to-signal pin ESD protection with the interdigitation pattern for ESD pin-to-rail protection network for differential pair circuitry is discussed for the first time. With integration of the ESD pin-to-rail solution and the ESD signal pin solution, a significant reduction of the area and loading effect for CMOS differential circuits is established. This novel concept will provide significant advantage for present and future high-performance analog and RF design for matching, area reduction, and performance advantages.
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology (2021)

Recent data suggest that the inhibition of arginase (ARG) has therapeutic potential for the treatment of a number of indications ranging from pulmonary and vascular disease to cancer. Thus, high demand exists for selective small molecule ARG inhibitors with favorable druglike properties and good oral bioavailability. In light of the significant challenges associated with the unique physicochemical properties of previously disclosed ARG inhibitors, we use structure-based drug design combined with a focused optimization strategy to discover a class of boronic acids featuring a privileged proline scaffold with superior potency and oral bioavailability. These compounds, exemplified by inhibitors <b>4a</b>, <b>18</b>, and <b>27</b>, demonstrated a favorable overall profile, and <b>4a</b> was well tolerated following multiple days of dosing at concentrations that exceed those required for serum arginase inhibition and concomitant arginine elevation in a syngeneic mouse carcinoma model.
[Cardio-renal axis: pathophysiological evidences and clinical implications]. (2017)

According to the recent definition proposed by the Consensus conference on Acute Dialysis Quality Initiative Group, the term cardio-renal syndrome CRS has been used to define different clinical conditions in which heart and kidney dysfunction overlap. Type 1 CRS acute cardio - renal syndrome is characterized by acute worsening of cardiac function leading to AKI in the setting of active cardiac disease such as ADHF, while type - 2 CRS occurs in a setting of chronic heart disease. Type 3 CRS is closely link to acute kidney injury, while type 4 represent cardiovascular involvement in chronic kidney disese patients. Type 5 CRS represent cardiac and renal involvement in several diseases such as sepsis, hepato - renal syndrome and immune - mediated diseases.
Normovolemic hemodilution with Hb vesicle solution attenuates hypoxia in ischemic hamster flap tissue (2003)

The aim of this study was to test whether oxygenation in acutely ischemic, collateralized tissue may be improved by normovolemic hemodilution with a solution containing liposome-encapsulated human Hb (HbV). A skin flap model in anesthetized hamsters was used, which consisted of two parts receiving either anatomic or collateral perfusion. Microhemodynamics were investigated with intravital microscopy. Partial tissue oxygen tension was measured with a Clark-type microprobe. Hemodilution was obtained by exchanging 50% of the total blood volume with HbV suspended in 8% human serum albumin (HSA8) or 6% Dextran 70 (Dx70). The size of the vesicles was 276 nm, the P(50) was 22 mmHg, and the Hb concentration of the solutions was 7.5 g/dl. Colloid osmotic pressure and viscosity were 49.9 mmHg and 8.7 cP for HbV-Dx70 and 40.0 mmHg and 2.9 cP for HbV-HSA8, respectively. Hemodilution with HbV-Dx70 led to an increase in microvascular blood flow in the ischemic microvessels to maximally 158% (median, P < 0.01), whereas blood flow remained virtually unchanged after hemodilution with HbV-HSA8. In the ischemic tissue, oxygen tension was improved from 11.9 to 17.0 mmHg (P < 0.01) after hemodilution with HbV-Dx70 but remained virtually unchanged after hemodilution with HbV-HSA8. Our study suggests that the oxygenation in acutely ischemic, collateralized tissue may be improved by normovolemic hemodilution with HbV suspended in Dx70. The effect was achieved by an increase in microcirculatory blood flow related to the rheological properties of the suspending medium.
Human type 1 and type 2 conventional dendritic cells express indoleamine 2,3‐dioxygenase 1 with functional effects on T cell priming (2021)

Dendritic cells (DCs) are key regulators of the immune system that shape T cell responses. Regulation of T cell induction by DCs may occur via the intracellular enzyme indoleamine 2,3-dioxygenase 1 (IDO), which catalyzes conversion of the essential amino acid tryptophan into kynurenine. Here, we examined the role of IDO in human peripheral blood plasmacytoid DCs (pDCs), and type 1 and type 2 conventional DCs (cDC1s and cDC2s). Our data demonstrate that under homeostatic conditions, IDO is selectively expressed by cDC1s. IFN-γ or TLR ligation further increases IDO expression in cDC1s and induces modest expression of the enzyme in cDC2s, but not pDCs. IDO expressed by conventional DCs is functionally active as measured by kynurenine production. Furthermore, IDO activity in TLR-stimulated cDC1s and cDC2s inhibits T cell proliferation in settings were DC-T cell cell-cell contact does not play a role. Selective inhibition of IDO1 with epacadostat, an inhibitor currently tested in clinical trials, rescued T cell proliferation without affecting DC maturation status or their ability to cross-present soluble antigen. Our findings provide new insights into the functional specialization of human blood DC subsets and suggest a possible synergistic enhancement of therapeutic efficacy by combining DC-based cancer vaccines with IDO inhibition.
Swift Morphosynthesis of Hierarchical Nanostructures of CdS via Microwave-Induced Semisolvothermal Route (2007)

For the swift generation of hierarchical nanostructures of CdS, we propose herein a docile microwave-induced semi-solvothermal reaction (i.e., involving simultaneous usage of nonaqueous and aqueous solvents) between cadmium acetate and thiourea in binary solution of diethylenetriamine and deionized water. Typically, such microwave-assisted reaction was accomplished within 5 minutes as against 12 h required in conventional approach. The resultant products were characterized by X-ray diffractometry, scanning electron microscopy, transmission electron microscopy, energy dispersive analysis by X-rays, laser Raman spectroscopy and photoluminescence spectroscopy. X-ray diffraction data indicates occurrence of hexagonal CdS with strong (002) preferred orientation. SEM images reveal formation of solvent-ratio dependent complex morphological (i.e., hierarchical) features both at the microscale and nanoscale. Fine-scale microstructure examination by TEM discloses formation of entangled nanorods, nano(potato)sticks, nanoflowers etc. Elemental analysis facility (equipped with TEM) suggests presence of Cd rich product. Raman spectroscopy shows the fundamental and overtone bands pertaining to hexagonal CdS with remarkable enhancement in relative intensities of such bands in case of sample corresponding to diethylenetriamine(DETA)/deionized water(DI) volume ratio of 6:1. Room temperature photoluminescence spectra mainly reveal broad asymmetric emission background composed of classical band edge and trap-induced emission in CdS.
Treatment and outcome of adult patients with acute asthma in emergency departments in Australasia, South East Asia and Europe: Are guidelines followed? AANZDEM/EuroDEM study (2021)

Objective Asthma exacerbations are common presentations to ED. Key guideline recommendations for management include administration of inhaled bronchodilators, systemic corticosteroids and titrated oxygen therapy. Our aim was to compare management and outcomes between patients treated for asthma in Europe (EUR) and South East Asia/Australasia (SEA) and compliance with international guidelines. Methods In each region, prospective, interrupted time series studies were performed including adult (age >18 years) patients presenting to ED with the main complaint of dyspnoea during three 72 h periods. This was a planned sub-study that included those with an ED primary diagnosis of asthma. Data was collected on demographics, clinical features, treatment in ED, diagnosis, disposition and in-hospital outcome. The results of interest were differences in treatment and outcome between EUR and SEA cohorts. Results Five hundred and eighty-four patients were identified from 112 EDs (66 EUR and 46 SEA). The cohorts had similar demographics and co-morbidity patterns, with 89% of the cohort having a previous diagnosis of asthma. There were no significant differences in treatment between EUR and SEA patients - inhaled beta-agonists were administered in 86% of cases, systemic corticosteroids in 66%, oxygen therapy in 44% and antibiotics in 20%. Two thirds of patients were discharged home from the ED. Conclusion The data suggests that compliance with guideline-recommended therapy in both regions, particularly corticosteroid administration, is sub-optimal. It also suggests over-use of antibiotics.
Ion-beam-sputtered AlOxNy encapsulating films (1979)

The encapsulating properties of 800–1500 Å aluminum oxynitride (AlOxNy) films, deposited on GaAs by low energy ion beam sputtering, were studied over a range of y from 0.1 to 0.8. Particular attention was given to chemical and sputter cleaning procedures. The structures were characterized by optical microscopy, electrical conductivity, Auger profiling, and ellipsometry. The better films were found to withstand annealing to above 900°C with minimal physical deterioration. The films with a higher proportion of oxygen allowed some oxygen diffusion; those made with inferior cleaning procedures allowed an out-diffusion of arsenic.
CLINICAL AND FUNDAMENTAL ASPECTS OF ANGIOGENESIS AND ANTI-ANGIOGENESIS (2007)

Insight into the fundamental physiological mechanisms of blood vessel development and neoformation has led to the discovery of multiple angiogenic growth factors and inhibitors. To date, at least 5 angiogenesis inhibitors are readily available for clinical use, mainly in the treatment of cancers and age-related macular degeneration. More inhibitors are yet to come and the indications for their clinical use are expected to broaden. Conversely, the use of angiogenic stimulators, although initially promising in animal models and in small uncontrolled pilot studies in patients with ischaemic heart disease or peripheral arterial occlusive disease, could thus far not show any convincing therapeutic improvement. Challenges still remain as to which angiogenic factor or combination of factors should be administered and in which form (protein versus gene), and what route and duration of administration should be used. Further clinical perspective might come from the recent identification of vascular endothelial growth factor (VEGF) as a modifier of the neurodegenerative disease amyotrophic lateral sclerosis (ALS), and as a promising therapy in the treatment of ALS in preclinical animal models. This review discusses the different clinical trials of angiogenic inhibitors and stimulators, preceded by some fundamental aspects of angiogenesis, giving the clinician a brief overview of the most relevant angiogenic topics.
Fast and Label-Free Isolation of Circulating Tumor Cells from Blood: From a Research Microfluidic Platform to an Automated Fluidic Instrument, VTX-1 Liquid Biopsy System (2018)

Tumor tissue biopsies are invasive, costly, and collect a limited cell population not completely reflective of patient cancer cell diversity. Circulating tumor cells (CTCs) can be isolated from a simple blood draw and may be representative of the diverse biology from multiple tumor sites. The VTX-1 Liquid Biopsy System was designed to automate the isolation of clinically relevant CTC populations, making the CTCs available for easy analysis. We present here the transition from a cutting-edge microfluidic innovation in the lab to a commercial, automated system for isolating CTCs directly from whole blood. As the technology evolved into a commercial system, flexible polydimethylsiloxane microfluidic chips were replaced by rigid poly(methyl methacrylate) chips for a 2.2-fold increase in cell recovery. Automating the fluidic processing with the VTX-1 further improved cancer cell recovery by nearly 1.4-fold, with a 2.8-fold decrease in contaminating white blood cells and overall improved reproducibility. Two isolation protocols were optimized that favor either the cancer cell recovery (up to 71.6% recovery) or sample purity (≤100 white blood cells/mL). The VTX-1's performance was further tested with three different spiked breast or lung cancer cell lines, with 69.0% to 79.5% cell recovery. Finally, several cancer research applications are presented using the commercial VTX-1 system.
Quantitative evaluation of brain iron accumulation in different stages of Parkinson's disease (2021)

Our data suggest iron accumulation occurs early in the disease course and only in the SN and RN of these patients. This is a large cross-sectional study of brain iron deposition in PD patients according to H&Y staging. Prospective studies are warranted to further validate QSM as a method to follow brain iron, which could serve as a disease biomarker and a therapeutic target.
Everett: Providing Branch-Isolation for a Data Evolution Service (2010)

One benefit of Software-as-a-Service (SaaS) is the ability to rapidly deploy iterative improvements without requiring users to upgrade the application on their machine. However, the need to rapidly "develop and test" different versions of an application implies that developers need branch isolation to protect the system from local changes to both data and meta-data in the same way that they traditionally use branch-isolation to protect the system from source-code changes. Providing branch-isolation for source-code changes has well-known solutions, but these solutions do not extend well to providing isolation for changes to data and meta-data. EVERETT provides developers the ability to safely - and concurrently - change database values with new business logic or evolve data schema in various ways while sharing the same database.
Tweak regulates astrogliosis, microgliosis and skeletal muscle atrophy in a mouse model of amyotrophic lateral sclerosis (2015)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that primarily affects motoneurons in the brain and spinal cord. Astrocyte and microglia activation as well as skeletal muscle atrophy are also typical hallmarks of the disease. However, the functional relationship between astrocytes, microglia and skeletal muscle in the pathogenic process remains unclear. Here, we report that the tumor necrosis factor-like weak inducer of apoptosis (Tweak) and its receptor Fn14 are aberrantly expressed in spinal astrocytes and skeletal muscle of SOD1(G93A) mice. We show that Tweak induces motoneuron death, stimulates astrocytic interleukin-6 release and astrocytic proliferation in vitro. The genetic ablation of Tweak in SOD1(G93A) mice significantly reduces astrocytosis, microgliosis and ameliorates skeletal muscle atrophy. The peripheral neutralization of Tweak through antagonistic anti-Tweak antibody ameliorates muscle pathology and notably, decreases microglial activation in SOD1(G93A) mice. Unexpectedly, none of these approaches improved motor function, lifespan and motoneuron survival. Our work emphasizes the multi-systemic aspect of ALS, and suggests that a combinatorial therapy targeting multiple cell types will be instrumental to halt the neurodegenerative process.
Pentacarbonyl iron(0) in zeolite Y: structure and reactivity (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPentacarbonyl iron(0) in zeolite Y: structure and reactivityChris Bowers and Prabir K. DuttaCite this: J. Phys. Chem. 1989, 93, 6, 2596–2603Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://doi.org/10.1021/j100343a069RIGHTS & PERMISSIONSArticle Views85Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts
Ultrasensitive Quantification of Hepatitis B Virus A1762T/G1764A Mutant by a SimpleProbe PCR Using a Wild-Type-Selective PCR Blocker and a Primer-Blocker-Probe Partial-Overlap Approach (2011)

Hepatitis B virus (HBV) carrying the A1762T/G1764A double mutation in the basal core promoter (BCP) region is associated with HBe antigen seroconversion and increased risk of liver cirrhosis and hepatocellular carcinoma (HCC). Quantification of the mutant viruses may help in predicting the risk of HCC. However, the viral genome tends to have nucleotide polymorphism, which makes it difficult to design hybridization-based assays including real-time PCR. Ultrasensitive quantification of the mutant viruses at the early developmental stage is even more challenging, as the mutant is masked by excessive amounts of the wild-type (WT) viruses. In this study, we developed a selective inhibitory PCR (siPCR) using a locked nucleic acid-based PCR blocker to selectively inhibit the amplification of the WT viral DNA but not the mutant DNA. At the end of siPCR, the proportion of the mutant could be increased by about 10,000-fold, making the mutant more readily detectable by downstream applications such as real-time PCR and DNA sequencing. We also describe a primer-probe partial overlap approach which significantly simplified the melting curve patterns and minimized the influence of viral genome polymorphism on assay accuracy. Analysis of 62 patient samples showed a complete match of the melting curve patterns with the sequencing results. More than 97% of HBV BCP sequences in the GenBank database can be correctly identified by the melting curve analysis. The combination of siPCR and the SimpleProbe real-time PCR enabled mutant quantification in the presence of a 100,000-fold excess of the WT DNA.
The Role of Therapeutic Plasma Exchange in Poisonings and Intoxications (2012)

Poisonings, intoxications, and drug overdoses are common occurrences and rapid lowering of the toxin level is a cornerstone of all effective therapies. Therapeutic plasma exchange (TPE) has several unique characteristics that allow it to be a potentially effective therapy in rapidly achieving this goal. Specifically, TPE allows for the removal of large molecular weight, protein-bound molecules that have a small volume of distribution. Due to the nature of poisonings, intoxications, and drug overdoses, no randomized controlled trials studying the efficacy of TPE in these situations exist. Thus, careful interpretation and analysis of case reports and series are required to assess the potential efficacy of this therapy. Recent data suggest that TPE may also be effective in the therapy of patients receiving biologic treatments who develop life-threatening complications due to therapy.