gebhart/patrepeval huggingface dataset:
Regulatory Roles for APJ, a Seven-transmembrane Receptor Related to Angiotensin-type 1 Receptor in Blood Pressure in Vivo (2004)

APJ is a G-protein-coupled receptor with seven transmembrane domains, and its endogenous ligand, apelin, was identified recently. They are highly expressed in the cardiovascular system, suggesting that APJ is important in the regulation of blood pressure. To investigate the physiological functions of APJ, we have generated mice lacking the gene encoding APJ. The base-line blood pressure of APJ-deficient mice is equivalent to that of wild-type mice in the steady state. The administration of apelin transiently decreased the blood pressure of wild-type mice and a hypertensive model animal, a spontaneously hypertensive rat. On the other hand, this hypotensive response to apelin was abolished in APJ-deficient mice. This apelin-induced response was inhibited by pretreatment with a nitric-oxide synthase inhibitor, and apelin-induced phosphorylation of endothelial nitric-oxide synthase in lung endothelial cells from APJ-deficient mice disappeared. In addition, APJ-deficient mice showed an increased vasopressor response to the most potent vasoconstrictor angiotensin II, and the base-line blood pressure of double mutant mice homozygous for both APJ and angiotensin-type 1a receptor was significantly elevated compared with that of angiotensin-type 1a receptor-deficient mice. These results demonstrate that APJ exerts the hypotensive effect in vivo and plays a counterregulatory role against the pressor action of angiotensin II.
Arnold: Declarative Crowd-Machine Data Integration (2013)

The availability of rich data from sources such as the World Wide Web, social media, and sensor streams is giving rise to a range of applications that rely on a clean, consistent, and integrated database built over these sources. Human input, or crowd-sourcing, is an effective tool to help produce such high-quality data. It is infeasible, however, to involve humans at every step of the data cleaning process for all data. We have developed a declarative approach to data cleaning and integration that balances when and where to apply crowd-sourcing and machine computation using a new type of data independence that we term Labor Independence. Labor Independence divides the logical operations that should be performed on each record from the physical implementations of those operations. Using this layer of independence, the data cleaning process can choose the physical operator for each logical operation that yields the highest quality for the lowest cost. We introduce Arnold, a data cleaning and integration architecture that utilizes Labor Independence to efficiently clean and integrate large amounts of data. 1.
Vacuum Ultraviolet Field Emission Lamp Consisting of Neodymium Ion Doped Lutetium Fluoride Thin Film as Phosphor (2014)

A vacuum ultraviolet (VUV) field emission lamp was developed by using a neodymium ion doped lutetium fluoride (Nd(3+) : LuF3) thin film as solid-state phosphor and carbon nanofiber field electron emitters. The thin film was synthesized by pulsed laser deposition and incorporated into the lamp. The cathodoluminescence spectra of the lamp showed multiple emission peaks at 180, 225, and 255 nm. These emission spectra were in good agreement with the spectra reported for the Nd(3+) : LuF3 crystal. Moreover, application of an acceleration voltage effectively increased the emission intensity. These results contribute to the performance enhancement of the lamp operating in the VUV region.
An adaptive frequency hopping technique for conducted-noise reduction in dc-dc converters (2012)

This paper introduces a novel technique for conducted-noise reduction in dc-dc converters. The converter is operated in variable frequency modulation regime. To avoid the “bad” switching frequencies□which cause tuning with the converter parasitic elements resonant frequencies and increase the noise peaks□these bad frequencies have been determined and removed from the hop-set frequencies. Furthermore, the effect of using the proposed controller on the conducted-noise characteristics of the converter has been experimentally investigated using an FPGA-based controller. Experimental results show that the conducted-noise spectrum has been significantly improved and the noise level has been effectively reduced.
TAPESTREA (2009)

TAPESTREA is a sound design and composition framework that facilitates the creation of new sound from existing digital audio recordings, through interactive analysis, transformation and re-synthesis. During analysis, sound templates of different types are extracted using a variety of techniques. Each extracted template is transformed and synthesized independently, allowing specialized transformations on each template based on its type. The user interacts with TAPESTREA via a set of graphical interfaces that offer parametric control over every stage of analysis, transformation and re-synthesis. Synthesis is further controlled through ChucK scripts. These combined techniques form a workbench for completely transforming a sound scene, dynamically generating soundscapes, or creating musical tapestries by weaving together transformed elements from different recordings. Thus, TAPESTREA introduces a new paradigm for composition, sound design, and sonic sculpting tasks.
In Situ Biasing TEM Characterization of Resistive Switching Phenomena in TiO2-based RRAM (2014)

Journal Article In Situ Biasing TEM Characterization of Resistive Switching Phenomena in TiO2-based RRAM Get access Jonghan Kwon, Jonghan Kwon Dept. of Materials Sci. and Eng., Carnegie Mellon University, Pittsburgh, PA 15213, USA Search for other works by this author on: Oxford Academic Google Scholar Abhishek A Sharma, Abhishek A Sharma Dept. of Electrical and Computer Eng., Carnegie Mellon University, Pittsburgh, PA 15213, USA Search for other works by this author on: Oxford Academic Google Scholar James A Bain, James A Bain Dept. of Electrical and Computer Eng., Carnegie Mellon University, Pittsburgh, PA 15213, USA Search for other works by this author on: Oxford Academic Google Scholar Yoosuf N Picard, Yoosuf N Picard Dept. of Materials Sci. and Eng., Carnegie Mellon University, Pittsburgh, PA 15213, USA Search for other works by this author on: Oxford Academic Google Scholar Marek Skowronski Marek Skowronski Dept. of Materials Sci. and Eng., Carnegie Mellon University, Pittsburgh, PA 15213, USA Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 20, Issue S3, 1 August 2014, Pages 1548–1549, https://doi.org/10.1017/S1431927614009477 Published: 27 August 2014
Upcycling of Dyed Polyester Fabrics into Copper-1,4-Benzenedicarboxylate (CuBDC) Metal–Organic Frameworks (2023)

We report on a pathway to synthesize metal–organic frameworks (MOFs) using discarded textiles as a raw material. Discarded objects made of poly(ethylene terephthalate) (PET) could be an inexpensive and globally available source for 1,4-benzenedicarboxylic acid (H2BDC), also known as terephthalic acid, a building block of carboxylate-based MOFs. Previous studies on using discarded PET to synthesize MOFs have mainly focused on PET bottles. In contrast, we demonstrate the use of dyed polyester fabrics as a raw material. Specifically, we report on a synthesis path for copper-1,4-benzenedicarboxylate (CuBDC) utilizing disodium terephthalate (Na2BDC) as a linker and on how we obtained the linker from depolymerized polyester fabrics. To facilitate coordination between the copper ions and Na2BDC and create a localized acidic environment that favors the synthesis of CuBDC MOFs rather than metal oxide byproducts, we added acetic acid to the copper precursor solution. The drop-sized pH-controlled domain enabled the formation of CuBDC MOF crystals at room temperature and at a fraction of time shorter than traditional solvothermal methods. We confirmed the resulting MOF structures using powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and Fourier transform infrared (FTIR) spectroscopy, and our results were in quantitative agreement with previous reports. Furthermore, we used different copper salts as metal sources and different color-dyed polyester fabrics as linker sources, demonstrating the versatility of the proposed synthesis path. These results may open an avenue for using discarded textiles as a raw material and offer a more circular approach for managing textile waste.
Supplementary Figures S1-S8 from A Threshold Level of Intratumor CD8<sup>+</sup> T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1 (2023)

&lt;p&gt;Supplementary Figures S1-S8. Anti-PD-1 reduces tumor weight and modulates PD-1 expressing intratumor T cells in anti-PD-1-sensitive tumor (S1); Anti-PD-1 therapy mAb does not compete for the binding of PD-1 with the anti-PD-1 flow cytometry staining mAb (S2); Anti-PD-1 mAb reduces PD-1 expression on PD-1-expressing T cells (S3); Frequency of PD-1+ CD8+ T cells maintained in anti-PD1-resistant Renca tumors (S4); Anti-Tim3 and anti-PD1 sensitivity correlates with reduced frequency of PD1 expressing CD8+ T cells (S5); Anti-PD-1/PD-L1 anti-tumor effect is FcR-independent (S6); PD-1-expressing T cells are predominantly found in the tumor microenvironment (S7); PD1 MFI on CD8+ T cells predicts tumor aggressiveness and response to anti-PD1 mAb in MC38 tumor (S8).&lt;/p&gt;
Geostatistics and Stochastic Modeling (2006)

Abstract There has been a remarkable expansion in the fields of geostatistics and spatiostochastic modeling during the decades spanning the advent of the new millennium. The nearly ubiquitous nature of spatial relationships across all disciplines and all walks of life is one of the most important scientific, social, and philosophical realizations of the era; and the evolution of thought and practice in geostatistics and spatiostochastic model reflects this newfound understanding. This chapter traces some of the major developments in these fields during this time frame, particularly in the geoscience context. It also presents a glimpse into the future regarding what geostatistics and spatiostochastic modeling might look like in the coming years.
Ge-Doped Microstructured Multicore Fiber for Customizable Supercontinuum Generation (2011)

Supercontinuum generation in a multicore fiber in which several uncoupled cores were doped with dissimilar concentrations of germanium was studied experimentally. Germanium doping provided control over the separation between the zero-dispersion wavelength and the 1064-nm wavelength of a Q-switched Nd:YAG pump laser. Supercontinua generated independently in each core of the same piece of fiber displayed clear and repeatable differences due to the influence of germanium doping on refractive index and four-wave mixing. The spectral evolution of the subnanosecond pump pulses injected into the different cores was accurately reproduced by numerical simulations.
Environmental Tuning of Homologs of the Orange Carotenoid Protein-Encoding Gene in the Cyanobacterium Fremyella diplosiphon (2021)

The orange carotenoid protein (OCP) family of proteins are light-activated proteins that function in dissipating excess energy absorbed by accessory light-harvesting complexes, i.e., phycobilisomes (PBSs), in cyanobacteria. Some cyanobacteria contain multiple homologs of the OCP-encoding gene (<i>ocp</i>). <i>Fremyella diplosiphon</i>, a cyanobacterium studied for light-dependent regulation of PBSs during complementary chromatic acclimation (CCA), contains several OCP homologs - two full-length OCPs, three Helical Carotenoid Proteins (HCPs) with homology to the N-terminus of OCP, and one C-terminal domain-like carotenoid protein (CCP) with homology to the C-terminus of OCP. We examined whether these homologs are distinctly regulated in response to different environmental factors, which could indicate distinct functions. We observed distinct patterns of expression for some OCP, HCP, and CCP encoding genes, and have evidence that light-dependent aspects of <i>ocp</i> homolog expression are regulated by photoreceptor RcaE which controls CCA. RcaE-dependent transcriptional regulator RcaC is also involved in the photoregulation of some <i>hcp</i> genes. Apart from light, additional environmental factors associated with cellular redox regulation impact the mRNA levels of <i>ocp</i> homologs, including salt, cold, and disruption of electron transport. Analyses of conserved sequences in the promoters of <i>ocp</i> homologs were conducted to gain additional insight into regulation of these genes. Several conserved regulatory elements were found across multiple <i>ocp</i> homolog promoters that potentially control differential transcriptional regulation in response to a range of environmental cues. The impact of distinct environmental cues on differential accumulation of <i>ocp</i> homolog transcripts indicates potential functional diversification of this gene family in cyanobacteria. These genes likely enable dynamic cellular protection in response to diverse environmental stress conditions in <i>F</i>. <i>diplosiphon</i>.
Effect of Frozen-in Vacancies on Hardness and Tensile Properties of Polycrystalline B2 FeAl (1994)

Polycrystalline B2 FeAl sheets containing 40 and 46 mol% aluminum were prepared by arc-melting and hot-rolling. After annealing at 1123 K, they were cooled to room temperature at three cooling rates; i.e. i) air-cooling (about 25 K·s−1), ii) 0.065 K·s−1 and iii) 0.01 K·s−1. Hardness values are localized around the average value except Fe-46 mol%Al cooled at 0.065 K·s−1. Hardness of the air-cooled samples is much higher than that of slowly cooled samples at 0.01 K·s−1 because of the introduction of frozen-in vacancies. The hardness values of Fe-46 mol%Al cooled at 0.065 K·s−1 are widely distributed from grain to grain, suggesting that the elimination rate of the vacancies is different on each grain. The temperature dependence of yield stress and elongation is obtained for both alloys air-cooled and annealed at 713 K for 150 h after air-cooling to eliminate frozen-in vacancies. Yield stress of the air-cooled Fe-40 mol%Al at 473 K is much higher than that of the vacancy-eliminated Fe-40 mol%Al and shows a strong negative temperature dependence. The vacancy-eliminated Fe-40 mol%Al shows a weak positive temperature dependence at 673 K to 873 K. The difference in the yield stress between the air-cooled and the vacancy-eliminated samples disappears above 873 K. The introduction of vacancies by air-cooling raises the ductile-brittle transition temperature (DBTT), and reduces elongation below the DBTT. Fe-46 mol%Al exhibits similar tensile properties to Fe-40 mol%Al, while the positive temperature dependence of yield stress does not occur even though the vacancy elimination treatment is done. Furthermore the DBTT of Fe-46 mol%Al vacancy-eliminated is higher than that of Fe-40 mol%Al, which is considered to be intrinsic for the aluminum composition dependence of the DBTT in B2 FeAl.
Abstract 2243A: Discovery of potent hedgehog pathway inhibitors as potential anticancer agents. (2013)

Abstract The hedgehog (Hh) pathway is critically important for embryonic development, and interference with the Hh pathway could result in severe birth defect. The Hh pathway is known to be highly activated in certain cancers such as basal cell carcinoma (BCC) and medulloblastoma. The approval of hedgehog pathway inhibitor Erivedge (vismodegib, GDC-0445) for the treatment of adults BCC by FDA in early 2012 validated Hh pathway as an anticancer target.In this presentation, we report the discovery of novel hedgehog pathway inhibitors and the identification of lead compounds that are 10-100 fold more potent in multiple in vitro assays than GDC-0449. Several of these potent compounds have been found to have good oral bioavailability and brain penetration. The in vivo efficacy studies of selected compounds are in progress. Citation Format: Sui Xiong Cai, Kai Xie, Sicun Li, Lizhen Wu, Lijun Liu, Feng Yin, Chengyun Gu, Xiaozhu Wang, Sishun Kang, Shengzhi Chen, Zheng Meng, Yan Zhang, Guoxiang Wang, Hongqiang Fei, Dongmei Wang, Ye Edward Tian. Discovery of potent hedgehog pathway inhibitors as potential anticancer agents. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2243A. doi:10.1158/1538-7445.AM2013-2243A
Pyridine‐Modified Acridine‐Based Bipolar Host Material for Green Phosphorescent Organic Light‐Emitting Diodes (2012)

A bipolar host material with a phenyl-modified acridine core and a pyridine unit in the molecular structure was synthesized as the host material for green phosphorescent organic light-emitting diodes (PHOLEDs). A high triplet energy of 2.76 eV was obtained from the host and a high quantum efficiency of 13.5 % was achieved in green PHOLEDs using the acridine-based host material.
Wafer‐Scale Functional Metasurfaces for Mid‐Infrared Photonics and Biosensing (2021)

Metasurfaces have emerged as a breakthrough platform for manipulating light at the nanoscale and enabling on-demand optical functionalities for next-generation biosensing, imaging, and light-generating photonic devices. However, translating this technology to practical applications requires low-cost and high-throughput fabrication methods. Due to the limited choice of materials with suitable optical properties, it is particularly challenging to produce metasurfaces for the technologically relevant mid-infrared spectral range. These constraints are overcome by realizing functional metasurfaces on almost completely transparent free-standing metal-oxide membranes. A versatile nanofabrication process is developed and implemented for highly efficient dielectric and plasmonic mid-infrared metasurfaces with wafer-scale and complementary metal-oxide-semiconductor (CMOS)-compatible manufacturing techniques. The advantages of this method are revealed by demonstrating highly uniform and functional metasurfaces, including high-Q structures enabling fine spectral selectivity, large-area metalenses with diffraction-limited focusing capabilities, and birefringent metasurfaces providing polarization control at record-high conversion efficiencies. Aluminum plasmonic devices and their integration into microfluidics for real-time and label-free mid-infrared biosensing of proteins and lipid vesicles are further demonstrated. The versatility of this approach and its compatibility with mass-production processes bring infrared metasurfaces markedly closer to commercial applications, such as thermal imaging, spectroscopy, and biosensing.
Self-assembled photosystem-I biophotovoltaics on nanostructured TiO(subscript 2) and ZnO (2012)

The abundant pigment-protein membrane complex photosystem-I (PS-I) is at the heart of the Earth’s energy cycle. It is the central molecule in the “Z-scheme” of photosynthesis, converting sunlight into the chemical energy of life. Commandeering this intricately organized photosynthetic nanocircuitry and re-wiring it to produce electricity carries the promise of inexpensive and environmentally friendly solar power. We here report that dry PS-I stabilized by surfactant peptides functioned as both the light-harvester and charge separator in solar cells self-assembled on nanostructured semiconductors. Contrary to previous attempts at biophotovoltaics requiring elaborate surface chemistries, thin film deposition, and illumination concentrated into narrow wavelength ranges the devices described here are straightforward and inexpensive to fabricate and perform well under standard sunlight yielding open circuit photovoltage of 0.5 V, fill factor of 71%, electrical power density of 81 µW/cm[superscript 2] and photocurrent density of 362 µA/cm[superscript 2], over four orders of magnitude higher than any photosystem-based biophotovoltaic to date.
Next Generation Microbolometers for High Resolution Remote Sensing (2006)

We describe our recent work on improving the time constant and NETD of uncooled microbolometer detector. Such improvement would enable infrared remote sensing with a spatial resolution better than 150 m from low earth orbits. Radiometric simulation of the new microbolometer designs shows that reduction of time constant by a factor of 3 and reduction of NETD by a factor of 1.5 can be achieved. Linear arrays of 512/spl times/3 microbolometers embedding the new designs have been fabricated for experimental validation.
An Experimentally Derived Database of Candidate Ras-Interacting Proteins (2007)

We used a TAP-tag approach to identify candidate binding proteins for the related Ras family GTPases: H-Ras, R-Ras, and Rap1A. Protein complexes were isolated from mouse fibroblasts, and component proteins were identified by a combination of nanoflow HPLC and tandem mass spectrometry. H-Ras was found to associate with numerous cytoskeletal proteins including talin-1. R-Ras and Rap1A each associated with various signaling molecules, many of which are membrane-associated. Thus, we have established the first database of potential Ras interactors in mammalian cells.
Molten salt-directed synthesis method for LiMn2O4nanorods as a cathode material for a lithium-ion battery with superior cyclability (2017)

A molten salt synthesis technique has been used to prepare nanorods of Mn2O3 and single-crystal LiMn2O4 nanorods cathode material with superior capacity retention. The molten salt-directed synthesis involved the use of NaCl as the eutectic melt. The as-synthesized LiMn2O4 nanorods cathode material showed superior electrochemical performance compared to the LiMn2O4 sample obtained via the solid state method. The as-synthesized LiMn2O4 nanorods maintained more than 95% of the initial discharge capacity of 107 mA h g−1 over 100 cycles at a rate of 0.1 C, whereas the LiMn2O4 sample synthesized using the solid state reaction method maintained 88% of the initial discharge capacity of 98 mA h g−1 over 100 cycles at a rate of 0.1 C. Compared to the literature, the molten salt-directed method for the preparation of high-performance LiMn2O4 is simpler and less expensive, with greater potential for industrial scale-up.
The effects of fuel composition on ignition delay in homogeneous charge and direct injection compression ignition engines (1987)

This report describes the work done at the University of Wisconsin-Madison in two experimental programs. In one program comparisons were made between comprehensive chemical kinetic mechanisms and experimental data for a homogeneous charge engine that was operated in either a spark ignited or compression ignited mode. The aim was to make an assessment of our ability to model the combustion of real fuels in I.C. engines. In the second program the effect of fuel composition on diesel engine performance was evaluated. In particular the effect of the chemical composition of the volatile fraction was examined for its effect on ignition properties and emissions of a direct injection diesel engine. Two analytics were prepared for this document.
Novel photocurrent-assisted wavelength (PAW) using a traveling-wave electroabsorption modulator with signal monitoring and regeneration capabilities (2004)

We report on a novel photocurrent-assisted wavelength converter using a traveling-wave electroabsorption modulator which also provides electrical monitoring and regeneration capabilities. The proposed concept is demonstrated with 2.5-Gb/s NRZ and 10-Gb/s RZ data formats.
Complex antigen presentation pathway for an HLA-A*0201-restricted epitope from Chikungunya 6K protein (2017)

Our data have implications not only for the identification of novel Alphavirus and Togaviridae antiviral CTL responses, but also for analyzing presentation of antigen from viruses of different families and orders that use host proteinases to generate their mature envelope proteins.