gebhart/patrepeval huggingface dataset:
Optimization of granular formulations of Metarhizium humberi microsclerotia with humectants (2021)

Granular microsclerotial formulations of entomopathogenic fungi deserve attention because of their post-application, in situ production of new conidia that enhance and prolong mycoinsecticidal efficacy against a target pest insect. Because high ambient moisture is a crucial condition to induce fungal development and conidiogenesis on granules, we tested the impacts of the additions of three humectants-glycerin, propylene glycol, and polyethylene glycol 400-on water absorption by pellets incorporating microsclerotia of Metarhizium humberi IP 46 with microcrystalline cellulose or vermiculite carriers, and on the production of infective conidia of IP 46 microsclerotia in ambient humidities suboptimal for routine conidiogenesis. Glycerin facilitated greater and faster absorption of water than the other humectants. Microcrystalline cellulose absorbed low quantities of water without any added humectant whereas vermiculite did not. IP 46 did not grow or sporulate on pellets prepared with or without glycerin at 86% relative humidity (RH) or on control pellets without glycerin at 91% RH; conidial production on pellets prepared with vermiculite or microcrystalline cellulose and 10% glycerin reached 1.1 × 10<sup>5</sup> conidia/mg and 1 × 10<sup>5</sup> conidia/mg, respectively, after 20 days of exposure at 91% RH. Hence, these results strongly support glycerin as a suitable humectant for granular microsclerotial formulations of this fungus.
Technique for Obtaining Raman Spectra of Supersaturated Solution in the Presence of a Growing Crystal in Situ (1985)

In the study of the fundamental mechanism of growth and nucleation of a crystal from an aqueous solution, it is essential that the structural nature of the supersaturated liquid be as well understood as possible. It is suspected that the species diffusing to the surface of growing crystals are not single ions but either ion pairs or clusters.
Fabrication and Characterization of an InAs(Sb)/InxGa1−xAsySb1−y Type‐II Superlattice (2019)

A novel InAs(Sb)/InxGa1−xAsySb1−y superlattice with high-indium-content InxGa1−xAsySb1−y in the immiscibility gap has been designed and fabricated through the fractional monolayer alloy growth method by Peng Du et al. (article number 1900474). Compared to the InAs/GaSb superlattice, this neoteric superlattice InAs(Sb)/InxGa1−xAsySb1−y exhibits a flexible miniband engineering ability and high luminescence property, which would have great potential applications in infrared optoelectronic devices.
Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO) (2019)

The prevalence of osteoarthritis (OA) increases not only because of longer life expectancy but also because of the modern lifestyle, in particular physical inactivity and diets low in fiber and rich in sugar and saturated fats, which promote chronic low-grade inflammation and obesity. Adverse alterations of the gut microbiota (GMB) composition, called microbial dysbiosis, may favor metabolic syndrome and inflammaging, two important components of OA onset and evolution. Considering the burden of OA and the need to define preventive and therapeutic interventions targeting the modifiable components of OA, an expert working group was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) to review the potential contribution of GMB to OA. Such a contribution is supported by observational or dietary intervention studies in animal models of OA and in humans. In addition, several well-recognized risk factors of OA interact with GMB. Lastly, GMB is a critical determinant of drug metabolism and bioavailability and may influence the response to OA medications. Further research targeting GMB or its metabolites is needed to move the field of OA from symptomatic management to individualized interventions targeting its pathogenesis.
Liquid-Crystalline Physical Gels Formed by the Aggregation of Trans-(1R,2R)-Bis(Dodecanoylamino)Cyclohexane in a Thermotropic Nematic Liquid Crystal. Phase Behavior and Electro-Optic Properties (1999)

Abstract Liquid-crystalline physical gels have been obtained by the self-association of hydrogen-bonded molecules in a room-temperature nematic liquid crystal. Thermoreversible three states, isotopic liquid, normal (isotropic) gel, and anisotropic gel can be achieved for these mixtures. Electro-optic properties of the anisotropic gels have been examined with a twisted nematic cell.
Designing a suitable lens shape for compatibility with the tear film (1980)

Vengono descritte le caratteristiche ideali di una lente a contatto che dovrebbe possedere una viscoelasticità che soddisfi i parametri fluido- meccanici del film lacrimale e che si mantenga in equilibrio dinamico indifferente sull'occhio per la corrispondenza dei baricentri tra sistema globo- oculare e lente stessa.
Data Supplement from p53MVA Therapy in Patients with Refractory Gastrointestinal Malignancies Elevates p53-Specific CD8<sup>+</sup> T-cell Responses (2023)

&lt;p&gt;Supplementary Figure 2. T cell phenotyping&lt;/p&gt;
COLIGATION OF CD40L (CD154) AND CD3 RESULTS IN CD4+ T CELL ACTIVATION AND THE INDUCTION OF APOPTOSIS. (1999)

500 Interaction of CD40 with its cognate ligand CD154 (CD40L) plays a critical role in B cell activation and isotype switching. We have recently demonstrated that the CD40L-specific antibody hu5C8 prevents rejection of mismatched renal allografts in primates. Using hu5C8 coimmobilized on beads with sub-optimal amounts of anti-CD3 to stimulate purified CD4 cells, we now report induction of specific and abortive activation of resting T cells. T cell function and signal transduction events were measured in purified CD4+ T cells following culture with antibodies bound to microsperes. Anti-CD3/CD40L-mediated responses were compared with both binding and non-binding control antibodies. Co-ligation of CD3 and CD40L induced expression of CD69, CD25 and ICAM-1 on most CD4 cells and CTLA4 on many. This activation was not dependent on CD28 since the addition of anti-B7-1 and anti-B7-2 mAbs did not prevent CD40L-mediated responses. CD3 and CD40L co-ligation resulted in increased production of TNF-α, IFN-γ and IL-10, but not IL-2. Interestingly, CD3/CD40L coligation resulted in CD4 cells proliferation for several days, but then the induction of death by apoptosis. Consistent with that observation, anti-CD3/CD40L costimulation failed to enhance expression of the anti-apoptotic gene Bcl-xl. Neutralizing antibodies to TNF-α or Fas-L did not prevent this apoptosis. Finally, this process was CSA-sensitive and associated with a gradual but sustained rise in intracellular calcium. Together these data suggest that the graft sparing effect of hu5C8 in vivo may in part result from enhanced secretion of IL-10 and apoptosis of allograft-specific CD4+ T cells.
Optical Metamaterials: From Magnetics with Rainbow Colors to Negative-Index and Cloaking (2007)

Metamaterials are expected to open a gateway to unprecedented electromagnetic properties and functionality unattainable from naturally occurring materials. We review this new emerging field and recent progress in demonstrating metamaterials in the optical range. Article not available.
Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes (1996)

The aim of this study was to investigate the expression and release of the IL-1 type II decoy receptor (R) in mononuclear phagocytes, which play a central role in immune and chronic inflammatory reactions. Human monocytes expressed both type I and type II R transcripts, the latter being two- to threefold more represented. By cross-linking and Ab blocking, the predominant surface IL-1-binding molecule was the decoy RII. IL-4, IL-13, and dexamethasone induced RI and RII transcripts and augmented the number of IL-1-binding sites with no modification of Kd values. The induced surface receptor was identified as the decoy RII. These stimuli induced the release of a soluble R with a m.w. of approximately 60 kDa, of which N-glycosylation contributed 22 kDa compared with 45 kDa released from polymorphonuclear leukocytes, of which N-glycosylation contributed 15 kDa. IL-13 and dexamethasone induced a release of 24 ng/ml/2 x 10(7) cells (from 8.7 to 43.2 ng/ml) and 25.6 ng/ml/2 x 10(7) cells (from 9.7 to 36.8 ng/ml) of decoy RII in 18 h, respectively (six donors). Thus, for instance, IL-13-treated (18 h) cells expressed 3.5 x 10(3) sites/cell and released 12 x 10(3) decoy RII/cell. The released decoy RII from monocytes bound IL-1apha and IL-1 receptor antagonist 30- and 2-fold less avidly than IL-1beta, respectively. In vitro-matured, monocyte-derived macrophages showed higher levels of surface expression and release of the IL-1 decoy RII. The results show that, on exposure to diverse molecules with anti-inflammatory properties, mononuclear phagocytes express and release copious amounts of a novel version of the soluble IL-1 decoy RII.
ChemInform Abstract: SYNTHESES OF 1,5‐DIDEOXY‐1,5‐IMINO‐D‐MANNITOL FROM D‐MANNOSE AND FROM D‐GLUCOSE (1985)

Abstract 1,5‐Didesoxy‐1,5‐imino‐D‐mannit (VI) wird nach zwei verschiedenen Wegen aus D‐Mannose (I) oder aus D‐Glucose (VII) in der angegebenen Weise nach bekannten Verfahrensschritten hergestellt.
Outdoor Experimental Trials of Millimeter-Wave Base Station Cooperation with Digital Beamforming in High-Mobility Environments for 5G Evolution (2020)

The fifth-generation (5G) mobile communications system initially introduced massive multiple-input multiple-output (M-MIMO) with analog beamforming (BF) to compensate for the larger path-loss in millimeter-wave (mmW) bands. 5G Evolution (5GE), which should be actualized around 2025, will replace analog BF with hybrid or fully digital BF that improves the mmW-band downlink/uplink transmission performance. In addition, 5GE requires base station (BS) cooperation technologies to provide stable and reliable cell-edge transmission in the mmW bands, even when mobile stations (MSs) travel at high speed. This paper introduces our developed 28-GHz-band trial equipment employing a novel BS cooperation technology with digital BF to track the MS mobility. We present evaluation results of outdoor experimental trials at a MS velocity of 90 km/h. Two M-MIMO antennas are deployed in the trials, and the BS cooperation selects one M-MIMO antenna based on the maximum received power criterion of a reference signal transmitted by the MS. The trials clarify that the BS cooperation maintains the maximum throughput in a wider area than non-BS cooperation at 90 km/h.
Extrinsic extraction pocedure for a small-signal GaN-HEMT model (2011)

This paper presents an extrinsic extraction procedure for a small-signal GaN-HEMT model with a distributed gate model using Z-parameters equations. Experimental validation is performed on multifinger 4×20 and 2×100 μm HEMTs.
Alpha 1 Anti-Trypsin (AAT): Novel Strategy to Treat Steroid Refractory Acute Graft Versus Host Disease (2016)

22 thus augmented ISC-dependent ex vivoregeneration without indirectly activating the ISC niche. We next evaluated IL-22 signaling. While western blot analysis indicated that IL-22 increased Stat3 and Stat1 phosphorylation in SI crypts, Lgr5 + ISCs demonstrated only Stat3 phosphorylation. Indeed, Stat1-deficient organoids demonstrated an intact growth response to IL-22, while Stat3 deficiency abrogated the effect of . To confirm Stat3 importance in vivo, we performed a gene set enrichment analysis and found that expression of an Lgr5 + ISC gene signature was significantly reduced in Stat3deficient mice with colitis, which was independently validated. Modeling radiation injury, we found that irradiation increased crypt IL-22 receptor expression, IL-22 increased the growth of SI organoids after ex vivo irradiation, and in vivo treatment with F-652 (a clinically translatable rhIL-22 dimer/Fc conjugate; Generon Corp.) significantly protected SI ISCs from irradiation. F-652 also increased the size of SI and LI organoids cultured ex vivo, and F-652 treatment starting 7 days after LP into C57BL/6 allogeneic BMT significantly reduced GVHD-related mortality. In summary, we found that IL-22 promotes ex vivo ISCdependent epithelial regeneration by activating Stat3, and treatment in vivo with a novel rhIL-22 compound significantly improved survival after experimental allogeneic BMT. IL-22 may provide a tissue-targeted approach for promotion of intestinal recovery without increasing post-transplant immunodeficiency.
Immunohistochemical study of the expression of E‐cadherin in canine mammary tumours (2003)

To investigate the possible role of E-cadherin in canine mammary tumours 20 benign and 40 malignant tumours were evaluated by immunohistochemistry in formalin-fixed paraffin wax-embedded samples. In all the benign tumours, E-cadherin was strongly expressed at the intercellular borders of epithelial cells, but it was less strongly expressed in 17 (43 per cent) of the malignant tumours. Furthermore, poorly differentiated carcinomas were less immunoreactive for E-cadherin than moderately and well differentiated carcinomas.
NCI Comparative Oncology Program Testing of Non-Camptothecin Indenoisoquinoline Topoisomerase I Inhibitors in Naturally Occurring Canine Lymphoma (2018)

These results demonstrate proof-of-mechanism for indenoisoquinoline TOP1 inhibitors supporting their further clinical development. They also highlight the value of the NCI Comparative Oncology Program (https://ccr.cancer.gov/Comparative-Oncology-Program) for evaluating novel therapies in immunocompetent pets with cancers.
High-precision calibration of spectrographs (2010)

Abstract We present the first stringent tests of a novel calibration system based on a laser frequency comb (LFC) for radial velocity measurements. The tests were obtained with the high-resolution, optical spectrograph, High Accuracy Radial velocity Planet Searcher. By using only one echelle order, we obtain a calibration repeatability of 15cms−1 for exposures that are several hours apart. This is comparable with a simultaneous calibration using a Th–Ar lamp that makes use of all 72 echelle orders. In both cases, the residuals are compatible with the computed photon noise. Averaging all LFC exposures, recorded over a few hours, we could obtain a calibration curve with residuals of 2.4ms−1. Thanks to the adjustable and optimally chosen line density of the LFC, we resolve a periodicity of 512 pixels in the calibration curve that is due to the manufacturing process of the CCD mask. Previous Th–Ar calibration was unable to resolve these systematic deviations, resulting in a deviation of up to 70ms−1 from the true calibration curve. In future, we hope to be able to make use of all echelle orders in order to obtain a calibration repeatability below 1cms−1 and absolute calibration within a few ms−1.
Curing process of silsesquioxane in self-organized diblock copolymer template (2009)

In the case that a self-organized diblock copolymer pattern is applied as an etching mask, one of the polymer components is required to have a high etching durability similar to that of silicon oxide. One suitable material for the purpose is a mixture of polystyrene-b-polyethyleneoxide (PS-PEO) and silsesquioxane (SSQ). After phase separation, the SSQ component is located only in PEO phase. By the following post-treatment, the polymer component was removed and residual cured SSQ structure was formed that could be available as etching mask. In this study, the authors investigated post-treatment process of SSQ in the mixed component system, comparing thermal treatment and oxygen plasma treatment. A significant difference was observed in the vertical shrinkage of the film thickness formed on a Si wafer. The plasma-treated film shrank to 72% of the baked film. By the examination of behavior of PS phase and PEO phase during post-treatment, respectively, it was found that the difference was caused by the curing behavior of SSQ in PEO. In the case of plasma treatment, the polymer component was removed before SSQ curing. As a consequence, plasma treatment gives voidless structure. Using the template as etching mask, 16nm pitch pattern was transferred to Si wafer.
Interworking between the Session Initiation Protocol (SIP) and the Extensible Messaging and Presence Protocol (XMPP): Addresses and Error Conditions (2013)

As a foundation for the definition of application-specific, bi-
directional protocol mappings between the Session Initiation Protocol
(SIP) and the Extensible Messaging and Presence Protocol (XMPP), this
document specifies the architectural assumptions underlying such
mappings as well as the mapping of addresses and error conditions.
59-05: Accelerometer based Rate Adaptive Pacing in Micra™ Transcatheter Pacemaker (2016)

Introduction: The Micra transcatheter pacemaker has similar functionality to conventional transvenous VVIR pacing systems despite its small size (0.8 cc) and intracardiac location. It provides rate responsive (RR) pacing using a programmable 3-axis accelerometer designed to detect patient activity in the presence of cardiac motion. We evaluated the RR performance during treadmill tests to maximum exertion. Methods: Patients underwent treadmill testing at 3 or 6-months post-implant with RR programming at physician discretion. Normalized sensor indicated rate (SIR) relative to the programmed upper sensor rate was modeled as a function of normalized workload in metabolic equivalents (METS) relative to maximum METS achieved during the test. A normalized MET and SIR was determined at the end of each 1 minute treadmill stage. The proportionality of SIR to workload was evaluated by comparing the slope from this relationship to the prospectively defined tolerance margin of 0.65 to 1.35. A slope of 1.0 would indicate linear RR throughout the workload range. Conclusion: Accelerometer based rate response was linear to workload confirming appropriate RR is achievable with an entirely intracardiac pacing system.
Titaniertes Methoxyallen als neuartiges Homoaldoläquivalent in diastereoselektiven Additionen an chirale Aminoaldehyde (1993)

Der vielseitige Synthesebaustein Methoxyallen zeigt sich hier von einer neuen Seite: Das aus ihm erhältliche Titanderivat 1 reagiert mit Aldehyden unter Allenylumkehr in γ‐Position. So entstehen mit α‐ N , N ‐Dibenzylaminoaldehyden 2 in hoher anti ‐Selektivität die Methoxyalkine anti ‐ 3 , die als aktivierte Carbonsäurederivate z.B. durch Hydrolyse in die Homostatinlactone anti ‐ 4 überführt werden können. R = CH 3 , CH 2 Ph, CH 2 CHMe 2 . magnified image
Subarachnoid hemorrhage induces reactive gliosis and brain injury (2008)

A wide range of CNS pathologies are known to induce reactive gliosis, including head trauma and injury, ischemic stroke, brain tumors and neurodegenerative diseases. Little is known, however, regarding the development of reactive gliosis following subarachnoid hemorrhage (SAH). The goals of this study are to characterize reactive gliosis following SAH and to determine the cellular basis of this phenomenon. Reactive gliosis was examined by the following criteria: (1) astroglial hypertrophy (detected by increased immunostaining of glial fibrillary acidic protein), (2) dedifferentiation of astrocytes (detected by re‐expression of nestin) and (3) increased metabolism of astrocytes (monitored by enhanced S‐100B production). Our results demonstrate that brain stem and cortex obtained from a rabbit SAH model exhibit these characteristics of reactive gliosis. As astrocytes have been shown to play a critical role in cerebral blood microcirculation, reactive gliosis following SAH could have a significant impact on the ability of astrocytes to communicate vasodilatory signals to parenchymal arterioles in response to neuronal activity. This work was supported by the Totman Medical Research Trust Fund, the Peter Martin Brain Aneurysm Endowment, AHA and the NIH (R20 RR16435 &amp; R01 HL078983).
From Electron Pumps to Spin Quantum Bits in Silicon (2018)

Motivated by electrical quantum metrology of the ampere we have developed versatile silicon CMOS based single-electron transistors and quantum dots. Besides charge quantization we can also control the spin degree of freedom of a single holes or electrons confined in those dots. Spin resonance has been observed in both cases although it was less expected for electrons. Furthermore we demonstrated the first spin hole quantum bit in CMOS technology, which offers exciting prospects most notably for scaling as its control is purely electrical thanks to spin-orbit interaction.
Benzoylurea Oligomers: Synthetic Foldamers That Mimic Extended α Helices (2007)

Nicht zu kurz und wellig: Ein neues Benzoylharnstoff-Foldamergerüst nimmt bevorzugt eine durch intramolekulare Wasserstoffbrücken bestimmte lineare Konformation ein (Bildmitte). Die funktionellen Gruppen R stehen ähnlich wie in einer α-Helix auf Lücke. Iterative Synthese und Variation der funktionellen Gruppen führt zu Strukturen mit Längen ähnlich denen natürlicher α-Helices (rechts).
The extent of incorporation of excess deuterium in the platinum-catalyzed reduction of unsubstituted cycloolefins by H2 in D2O/THF increases with the strain energy of the product cycloalkanes (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe extent of incorporation of excess deuterium in the platinum-catalyzed reduction of unsubstituted cycloolefins by H2 in D2O/THF increases with the strain energy of the product cycloalkanesT. Randall Lee and George M. WhitesidesCite this: J. Am. Chem. Soc. 1991, 113, 1, 369–370Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/ja00001a059https://doi.org/10.1021/ja00001a059research-articleACS PublicationsRequest reuse permissionsArticle Views72Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modulating gut immunity and neoplasia with oral cytokine adjuvants (2015)

Oral administration of particulate IL-10 suppressed polyposis, ameliorated systemic pathology and extended lifespan in APC<sup>min/+</sup> mice. Therapeutic effect was associated with selective activity of IL-10 on intestinal CD4+Foxp3+RORγt+IL-17+ pathogenic T-regulatory cells. Studies were recently extended to a bacterially-driven murine colon adenocarcinoma model with similar results. Clinical implications of these findings are discussed.