gebhart/patrepeval huggingface dataset:
Toward application of conformal decomposition finite elements to non‐colloidal particle suspensions (2012)

SUMMARY Particle suspensions play an important role in many engineering applications, yet their behavior in a number of respects remains poorly understood. In conjunction with careful experiments, modeling and simulation of these systems can provide key insight into their complex behavior. However, these two‐phase systems pose the challenge of simultaneously, accurately, and efficiently capturing the complex geometric structure, kinematics, and dynamics of the particulate discrete phase and the discontinuities it introduces into the variables (e.g., velocity, pressure, density) of the continuous phase. To this end, a new conformal decomposition finite element method (CDFEM) is introduced for solid particles in a viscous fluid. The method is verified in several simple test problems that are representative of aspects of particle suspension behavior. In all cases, we find the CDFEM to perform accurately and efficiently leading to the conclusion that it forms a prime candidate for application to the full direct numerical simulation of particle suspensions. Copyright © 2012 John Wiley &amp; Sons, Ltd.
High-resolution brain tumor visualization using three-dimensional x-ray phase contrast tomography (2007)

We report on significant advances and new results concerning a recently developed method for grating-based hard x-ray phase tomography. We demonstrate how the soft tissue sensitivity of the technique is increased and show in vitro tomographic images of a tumor bearing rat brain sample, without use of contrast agents. In particular, we observe that the brain tumor and the white and gray brain matter structure in a rat's cerebellum are clearly resolved. The results are potentially interesting from a clinical point of view, since a similar approach using three transmission gratings can be implemented with more readily available x-ray sources, such as standard x-ray tubes. Moreover, the results open the way to in vivo experiments in the near future.
Using Storage Class Memory Efficiently for an In-memory Database (2016)

Storage class memory (SCM) is an emerging class of memory devices that are both byte addressable, and persistent. There are many different technologies that can be considered SCM, at different stages of maturity. Examples of such technologies include NVDIMM-N, PCM, SttRAM, Racetrack, FeRAM, and others.
Efflorescent (2016)

This Glossary of Terms Related to Pharmaceutics is needed by practitioners in the field of pharmaceutics as this field fulfills an important and crucial role, different from the roles of other scientific disciplines involved in the drugmaking process. The glossary contains 168 definitions used in pharmaceutics. These are related to various aspects of this discipline, such as: (1) physicochemical characterization of pharmaceutical preparations and the active ingredients they contain; (2) unit operations used in the practice of pharmaceutics; (3) terms related to the various dosage forms; (4) terms related to the various modes and routes of drug delivery; (5) terms used in pharmacokinetics and biopharmaceutics in general; and additional miscellaneous terms. The field of pharmaceutics itself is of a multidisciplinary nature as its practitioners come from a variety of disciplines, such as chemistry or various biological sciences, thus a glossary containing authoritative definitions would be useful for them. The terms used in pharmaceutics are rarely covered by existing glossaries, and in the cases they are, their definitions are often inappropriate for the field of pharmaceutics and require new or modified definitions to better fit the new context.
Intraoperative high-dose rate interstitial irradiation of hepatic metastases from colorectal carcinoma.Results of a phase I–II trial (1993)

This innovative, radical approach to unresectable colorectal hepatic metastases proved safe. Additional study is needed to determine whether interstitial irradiation is as effective as surgical resection, or whether it alters the natural history of the disease or longevity.
Both variant and IGHV4-34–expressing hairy cell leukemia lack the BRAF V600E mutation (2011)

Recently, the BRAF V600E mutation was reported in all cases of hairy cell leukemia (HCL) but not in other peripheral B-cell neoplasms. We wished to confirm these results and assess BRAF status in well-characterized cases of HCL associated with poor prognosis, including the immunophenotypically defined HCL variant (HCLv) and HCL expressing the IGHV4-34 immunoglobulin rearrangement. Fifty-three classic HCL (HCLc) and 16 HCLv cases were analyzed for BRAF, including 5 HCLc and 8 HCLv expressing IGHV4-34. BRAF was mutated in 42 (79%) HCLc, but wild-type in 11 (21%) HCLc and 16 (100%) HCLv. All 13 IGHV4-34(+) HCLs were wild-type. IGHV gene usage in the 11 HCLc BRAF wild-type cases included 5 IGHV4-34, 5 other, and 1 unknown. Our results suggest that HCLv and IGHV4-34(+) HCLs have a different pathogenesis than HCLc and that a significant minority of other HCLc are also wild-type for BRAF V600.
Islet culture improves islet viability by increasing ATP content and OCR. (2015)

&lt;p&gt;&lt;i&gt;(&lt;/i&gt;&lt;b&gt;&lt;i&gt;a&lt;/i&gt;&lt;/b&gt;&lt;i&gt;)&lt;/i&gt; ATP was measured and normalized to DNA content (nmol/mg protein/mg-DNA) as described in &lt;i&gt;“&lt;/i&gt;&lt;a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0099796#s2" target="_blank"&gt;&lt;i&gt;Materials and Methods&lt;/i&gt;&lt;/a&gt;&lt;i&gt;”&lt;/i&gt;. Graphic represents ATP/DNA values. Results are means ± SEM of five separate experiments performed in triplicate (n = 5, &lt;i&gt;&lt;sup&gt;**&lt;/sup&gt;P&lt;0.01&lt;/i&gt; for &lt;i&gt;D&lt;sub&gt;0&lt;/sub&gt;&lt;/i&gt; (black bars) &lt;i&gt;vs. D&lt;sub&gt;7&lt;/sub&gt;&lt;/i&gt; (grey bars)). &lt;i&gt;(&lt;/i&gt;&lt;b&gt;&lt;i&gt;b&lt;/i&gt;&lt;/b&gt;&lt;i&gt;)&lt;/i&gt; Islet samples were used for OCR measurements normalized to DNA content (nmolO&lt;sub&gt;2&lt;/sub&gt;/min/mg-DNA) as described in &lt;i&gt;“&lt;/i&gt;&lt;a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0099796#s2" target="_blank"&gt;&lt;i&gt;Materials and Methods&lt;/i&gt;&lt;/a&gt;&lt;i&gt;”&lt;/i&gt;. Graphic represents OCR/DNA values. Data are means ± SEM of eighteen separate experiments performed in triplicate (n = 18, &lt;i&gt;&lt;sup&gt;***&lt;/sup&gt;P&lt;0.001&lt;/i&gt; for &lt;i&gt;D&lt;sub&gt;0&lt;/sub&gt; vs. D&lt;sub&gt;7&lt;/sub&gt;&lt;/i&gt;). &lt;i&gt;(&lt;/i&gt;&lt;b&gt;&lt;i&gt;c/d&lt;/i&gt;&lt;/b&gt;&lt;i&gt;)&lt;/i&gt; Protein extracts (30 µg) from islet samples with &lt;i&gt;(&lt;/i&gt;&lt;b&gt;&lt;i&gt;c&lt;/i&gt;&lt;/b&gt;&lt;i&gt;)&lt;/i&gt; high or &lt;i&gt;(&lt;/i&gt;&lt;b&gt;&lt;i&gt;d&lt;/i&gt;&lt;/b&gt;&lt;i&gt;)&lt;/i&gt; low JNK3 protein content in &lt;i&gt;D&lt;sub&gt;0&lt;/sub&gt;&lt;/i&gt; and &lt;i&gt;D&lt;sub&gt;7&lt;/sub&gt;&lt;/i&gt; were tested by Western blot. Polyclonal antibodies against: p-Akt1, p-Akt2, p-GSK3β, JNK3, MKK7, Akts and PTEN were used. Equal protein loading was assessed by blotting membranes with antibodies against tubulin and GAPDH. Data are representative of at least three separate experiments (n = 3–8).&lt;/p&gt;
Nonlinear elasto-plastic analysis of wire bond reliability for optical LQFP package (2005)

Nonlinear thermo-mechanical simulation is performed on optical low-profile quad flat package (OLQFP) to understand the root cause of the failure and to optimize the package design for improved wire bond reliability. 3D finite element model is established. Gold wire is considered as elasto-plastic material, which the properties are derived from the stress-strain curves measured at different temperatures. It is found that the total equivalent strain of the wire at stitch region is high during reflow process and on the other hand, the ultimate strain of gold wire at reflow temperature is low. Thus, the high strain in the stitch region during reflow is the root cause of the failure. The equivalent plastic strain and accumulated plastic strain during reflow and the following thermal cycling test are also analyzed in detail. Based on this methodology, the downset of die pad is optimized to improve the wire bond reliability during reflow. It should be noted that although the wire bond reliability may be improved during reflow by decreasing the downset, the life of the wire bond during the subsequent thermal cycling test may be compromised. Design guidelines are provided and discussed in the paper.
IMT-2020 Key Performance Indicators: Evaluation and Extension Towards 5G New Radio Point-to-Multipoint (2019)

5G New Radio (5G NR) is the first technology standard to enable mobile communications in three different usage scenarios: enhanced Mobile Broadband (eMBB), Ultra-Reliable Low Latency Communications (URLLC) and massive Machine Type Communications (mMTC). As a result of its technical impact, ITU-R considers 5G NR as candidate technology for the International Mobile Telecommunications for 2020 (IMT-2020) evaluation process. To assess 5G NR performance, IMT-2020 defines multiple Key Performance Indicators (KPIs) related to specific requirements to enable Point-to-Point communications (PTP). IMT-2020 does not consider Point-to-Multipoint (PTM) communications due to the absence of multicast/broadcast capabilities in the current 5G NR standardized solution. Nevertheless, PTM communications are proved to be a key feature for 5G applications in a wide number of vertical sectors as Media & Entertainment, Public Warning or Internet of Things. This paper performs an analysis of different IMT-2020 KPIs for 5G NR PTP and extends the evaluation to a PTM perspective. The results contribute to enhance the role of PTM communications towards the IMT2020 landmark.
Neutrophil Phagocytosis of Platelets in the Early Phase of 2,4,6-trinitro-1-chlorobenzene (TNCB)-induced Dermatitis in Mice (2014)

Activated platelets form platelet-leukocyte aggregates in the circulation in inflammatory diseases. We investigated whether activated platelets in inflamed skin tissues are phagocytized and removed by neutrophils. To investigate the kinetics of platelets and neutrophils, we immunohistochemically examined the spatiotemporal distribution of them in a murine model of 2,4,6-trinitro-1-chlorobenzene (TNCB)-induced dermatitis by using confocal and structured illumination microscopy. Four hours after elicitation, aggregates of CD41-positive platelets were adhered to CD31-positive endothelial cells within the vessels, and CD62P and PF4, markers of activated platelets, were expressed on platelet aggregates. At 8 hour post-elicitation, fragmented CD41-positive platelets were located both inside and outside vessels. Twenty-four hours after elicitation, the number of Ly-6G-positive neutrophils ingesting fragmented CD41-positive platelets outside vessels was increased, and CD62P and PF4 expression on the phagocytosed platelets was no longer observed. Disc-shaped CD41-positive platelets were not found outside vessels at any time during the experiment. Our data revealed that aggregates of activated platelets inside vessels were ingested and removed by neutrophils in the early stage of TNCB-induced dermatitis, suggesting that the process of removal of activated platelets by neutrophils may play an important role not only in the early phase of skin inflammation but also in other types of acute inflammation.
Down syndrome: Toward a molecular definition of the phenotype (2005)

Down syndrome (DS) is a major cause of mental retardation and heart disease. Although it is usually caused by the presence of an extra chromosome 21, a subset of the diagnostic features may be caused by the presence of only band q22. Molecular and cytogenetic analysis of a family with 4 DS members has significantly narrowed the chromosomal region responsible for the DS phenotype: congenital heart disease, facial features, and possibly dermatoglyphics. Using high-resolution chromosome banding and in situ hybridization, we found the DS phenotype in the family is caused by a duplication of chromosome 21 material including a region of distal band q22.1 below the limit of cytogenetic resolution, in addition to bands q22.2-q22.3. By quantitative Southern blot analyses of DS members of the family, all random DNA sequences and expressed genes mapping in band q22.1 and proximal are found not to be duplicated. These include cDNA probes for the genes for superoxide dismutase (SOD1) mapping in 21q22.1 and for the amyloid precursor protein (APP) mapping in 21q21.05; D21S46 in 21q11.2-21.05; and D21S47 and SF57 in 21q22.1-q22.3. With one exception, DNA sequences mapping in band q22.3 are duplicated (D21S39, D21SD42, and D21S43). This analysis has now been extended to show that D21S17, previously mapped to band 21q22.3, is not duplicated. In conclusion, the genes SOD1 and APP have been excluded from a necessary role in generating the classical DS features, and the proximal border of the chromosomal region causing DS has been defined.
The double edged sword of the immune response: mutational analysis of a murine anti-pneumococcal, anti-DNA antibody. (1996)

Anti-double-stranded (ds) DNA antibodies are not only an important diagnostic marker for SLE, but also play an important role in tissue injury. Microbial antigen may be a stimulus for the production of these antibodies. We isolated 99D.7E, an IgG2b monoclonal antibody from a nonautoimmune BALB/c mouse that is cross-reactive with both dsDNA and phosphorylcholine, the dominant hapten on the pneumococcal cell wall. While partially protective against a bacterial challenge, 99D.7E is also pathogenic to the kidney. To identify those molecular motifs that confer on anti-PC antibodies the potential for autoreactivity, we created a panel of 99D.7E mutants with single amino acid substitutions in the heavy chain, and examined the changes in antigen binding and renal deposition. Our results support the hypothesis that charge and affinity for dsDNA are not adequate predictors of the pathogenicity of anti-DNA antibodies. Differential renal damage from anti-dsDNA antibodies may be due to differences in fine specificity, rather than differential affinity for dsDNA. Importantly, high affinity IgG antibodies cross-reactive with bacterial and self antigen exist and can display pathogenic potential, suggesting that defects in peripheral regulation of B cells, activated by foreign antigen but cross-reactive with self antigen, might lead to autoimmune disorders.
Photoprotection and vitamin D status (2019)

Vitamin D is produced by the skin in response to ultraviolet radiation (UVR) from sunlight. A lack of vitamin D, known as vitamin D deficiency, can cause bones to become soft and weak, which can lead to bone deformities. Whilst UVR exposure is a main source of vitamin D, it is also a primary cause of skin cancer, leading to debates on how to get the balance between ideal (sufficient) vitamin D levels and sun protection.
Fusion of bone marrow–derived stem cells with striated muscle may not be sufficient to activate muscle genes (2004)

Several studies have demonstrated the existence of pluripotent bone marrow–derived stem cells capable of homing to injured cardiac and skeletal muscle; however, there has been little evidence demonstrating the induction of tissue-specific endogenous genes in donor stem cells following engraftment. A new study in this issue reports an intriguing finding that raises additional concerns relating to stem cell plasticity and stem cell therapy in an already heated and controversial field. The study demonstrates that wild-type bone marrow–derived side population stem cells are indeed readily incorporated into both skeletal and cardiac muscle when transplanted into mice that lack δ-sarcoglycan — a model of cardiomyopathy and muscular dystrophy. However, these cells fail to express sarcoglycan and thus to repair the tissue, which suggests that this stem cell population has limited potential for cardiac and skeletal muscle regeneration.
Neptunium Oxide Target Fabrication Facility Considerations for the Production of Plutonium-238 (1994)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Louis H. Goldmann, Ivan L. Metcalf, Kenneth E. Schwartz; Neptunium Oxide Target Fabrication Facility Considerations for the Production of Plutonium‐238. AIP Conf. Proc. 1 July 1994; 301 (1): 1463–1470. https://doi.org/10.1063/1.2950165 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Table S4 from MCL1 and DEDD Promote Urothelial Carcinoma Progression (2023)

&lt;p&gt;Sequences for arrayed RNAi vectors used&lt;/p&gt;
Advances in the generation of transgenic pigs via embryo-derived and primordial germ cell-derived cells (2020)

The development of new technologies that would increase the efficiency for generation of transgenic livestock and would overcome some of the problems associated with random insertion of the transgene will greatly benefit animal agriculture. A potential alternative technology to pronuclear injection for the generation of transgenic pigs involves the isolation, culture and genetic manipulation of cell lines that can be reintroduced into the embryo for participation in the formation of the germ cells We have isolated and cultured pig primordial germ cells (PGC) while maintaining them in an undifferentiated state as determined by morphology and alkaline phosphatase (AP) activity. More importantly, PGC-derived cells were stably transformed with the green fluorescent protein . marker driven by the cytomegalovirus promoter. After visual identification of transgenic colonies, the pluripotential characteristics of the transgenic PGC-derived cells were tested by chirnaera formation and to date we have identified, by genomic Southern blots, two chimaeric fetuses that contain tissues with the transgene incorporated into their chromosomes. To our knowledge, this is the first report of a chimaeric transgenic pig fetus obtained via a cultured cell line.
A DNA Segment Encoding Two Genes Very Tightly Linked to Huntington's Disease (1987)

The discovery of D4S10, an anonymous DNA marker genetically linked to Huntington's disease (HD), introduced the capacity for limited presymptomatic diagnosis in this late-onset neurodegenerative disorder and raised the hope of cloning and characterizing the defect based on its chromosomal location. Progress on both fronts has been limited by the absence of additional DNA markers closer to the HD gene. An anonymous DNA locus, D4S43, has now been found that shows extremely tight linkage to HD. Like the disease gene, D4S43 is located in the most distal region of the chromosome 4 short arm, flanked by D4S10 and the telomere. In three extended HD kindreds, D4S43 displays no recombination with HD, placing it within 0 to 1.5 centimorgans of the genetic defect. Expansion of the D4S43 region to include 108 kilobases of cloned DNA has allowed identification of eight restriction fragment length polymorphisms and at least two independent coding segments. In the absence of crossovers, these genes must be considered candidates for the site of the HD defect, although the D4S43 restriction fragment length polymorphisms do not display linkage disequilibrium with the disease gene.
Hybrid GRAND Sphere Decoding: Accelerated GRAND for Low-Rate Codes (2023)

Guessing random additive noise decoding (GRAND) and sphere decoding (SD) are two algorithms that can achieve maximum likelihood decoding. In this paper, a hybrid GRAND-SD (HGRAND) scheme is proposed to extend GRAND to low-rate codes. An accelerated GRAND decoder, assisted by a sphere decoder running in parallel and giving hints to it to allow skipping of certain candidates allows HGRAND to achieve a latency below the minimum latency of the individual component decoders while guaranteeing error-correction performance.
The Light Field Video Camera (2000)

Abstract : We present the Light Field Video Camera, an array of CMOS image sensors for video image based rendering applications. The device is designed to record a synchronized video dataset from over one hundred cameras to a hard disk array using as few as one PC per fifty image sensors. It is intended to be flexible, modular and scalable, with much visibility and control over the cameras. The Light Field Video Camera is a modular embedded design based on the 1EEE1394 High Speed Serial Bus, with an image sensor and MPEG2 compression at each node. We show both the flexibility and scalability of the design with a six camera prototype.
Evolution and Study of Polymer-Supported Metal Catalysts for Oxygen Atom Transfer:  Oxidation of Alkanes and Alkenes by Diamide Manganese Complexes (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTADDITION / CORRECTIONThis article has been corrected. View the notice.Evolution and Study of Polymer-Supported Metal Catalysts for Oxygen Atom Transfer: Oxidation of Alkanes and Alkenes by Diamide Manganese ComplexesMiroslav Havranek, Arun Singh, and Dalibor SamesView Author Information Department of Chemistry, Columbia University New York, New York 10027 Cite this: J. Am. Chem. Soc. 1999, 121, 38, 8965–8966Publication Date (Web):September 15, 1999Publication History Received26 April 1999Published online15 September 1999Published inissue 1 September 1999https://pubs.acs.org/doi/10.1021/ja991336fhttps://doi.org/10.1021/ja991336frapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views687Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Ligands,Oxidation,Oxygen,Transition metals Get e-Alerts