gebhart/patrepeval huggingface dataset:
Access Control Model for Time Series Databases using NGAC (2020)

In Industry 4.0 and Industrial Internet of Things (IIoT), large amounts of time-series sensor data is collected from devices and machines. Industrial data typically contain sensitive information that may harm the data owner should it leaks. Although such risks exist, selected data frequently needs to be shared in partner eco-systems to take advantage of expertise in analyzing the data and to synchronize between partners collaborating in the production system. Consequently, access control must support efficient data selection and sharing. The access control should be capable of managing and enforcing access policies for different operations and with different levels of granularity, while being simple to properly maintain and potentially automate. In this paper we examine the possible use of Next-Generation Access Control (NGAC) for such access control. NGAC is an attribute-based access control (ABAC) standard based on relations between data elements to create, manage and enforce access control policies. We propose an Access control model that maps the NGAC policy language to the query language of time-series databases to facilitate a secure and efficient data sharing system for IIoT sensor data.
Levulinic Acid Is a Key Strategic Chemical from Biomass (2022)

Levulinic acid (LA) is one of the top twelve chemicals listed by the US Department of Energy that can be derived from biomass. It serves as a building block and platform chemical for producing a variety of chemicals, fuels and materials which are currently produced in fossil based refineries. LA is a key strategic chemical, as fuel grade chemicals and plastic substitutes can be produced by its catalytic conversion. LA derivatisation to various product streams, such as alkyl levulinates via esterification, γ-valerolactone via hydrogenation and N-substituted pyrrolidones via reductive amination and many other transformations of commercial utility are possible owing to the two oxygen functionalities, namely, carbonyl and carboxyl groups, present within the same substrate. Various biomass feedstock, such as agricultural wastes, marine macroalgae, and fresh water microalgae were successfully converted to LA in high yields. Finding a substitute to mineral acid catalysts for the conversion of biomass to LA is a challenge. The use of an ultrasound technique facilitated the production of promising nano-solid acid catalysts including Ga salt of molybophosphoric acid and Ga deposited mordenite zeolite, with optimum amounts of Lewis and Bronsted acidities needed for the conversion of glucose to LA in high yields, being 56 and 59.9 wt.% respectively. Microwave irradiation technology was successfully utilized for the accelerated production of LA (53 wt.%) from glucose in a short duration of 6 min, making use of the unique synergistic catalytic activity of ZnBr2 and HCl.
Double exponential approximation and inverse double exponential fit for Bell Labs and International-Military Standard EMP waveforms (2020)

We summarize here the double exponential and inverse double exponential approximations for two common EMP waveforms, the Bell Laboratories (Bell Labs) and the International- military standard (IEC-MIL-STD). Both models have been used frequently due to their relatively easy analytical expressions for both the time domain waveforms and their associated frequency domain spectra.
Micro-RNA bei Endometriose – Verlaufsparameter und Therapiekontrollmarker? (2020)

Einleitung Die Endometriose ist eine gutartige Erkrankung in der Gynäkologie, von der ca. 10 -15 % aller geschlechtsreifen Frauen betroffen sind [Coleman et al. 2015]. MicroRNAs (miRNAs) sind sowohl bei der Regulation physiologischer Prozesse wie Entwicklung, Wachstum und Differenzierung, als auch bei der Pathogenese verschiedenster Erkrankungen von zentraler Bedeutung.
Photoluminescence Study of Phosphorus‐Doped LPCVD Silicon Epilayers Deposited from Dichlorosilane (1991)

A set of phosphorus‐doped low pressure chemical vapor deposition Si epilayers grown from have been characterized using both dispersive and FTIR photoluminescence (PL) spectroscopy. By simultaneously growing each layer on three types of substrate, subsequent PL analysis can unambiguously identify epilayer emission. The principal shallow dopant has a relatively high radiative efficiency in all layers deposited within the temperature range 850–1050°C, there being no evidence for any competing deep radiative centers within the 0.7–1.1 eV photon range. It is shown, for the first time, that shallow bound exciton luminescence from thin (∼1 μm) Si epilayers grown at low temperature can be readily observable. Photoluminescence is also shown to be capable of qualitatively monitoring variations in vertical and lateral autodoping of epilayers from heavily doped substrates.
Electrical Performance and Scalability of Pt Dispersed SiO2Nanometallic Resistance Switch (2013)

Highly reproducible bipolar resistance switching was recently demonstrated in a composite material of Pt nanoparticles dispersed in silicon dioxide. Here, we examine the electrical performance and scalability of this system and demonstrate devices with ultrafast (<100 ps) switching, long state retention (no measurable relaxation after 6 months), and high endurance (>3 × 10(7) cycles). A possible switching mechanism based on ion motion in the film is discussed based on these observations.
Mechanisms of tissue uptake and retention of paclitaxel-coated balloons: impact on neointimal proliferation and healing (2014)

The presence of paclitaxel deposits on the vessel surface driving diffusion into the arterial tissue in a time-dependent fashion supports the mechanism of action of PCB. This specific pharmacokinetic behaviour influences the patterns of neointimal formation and healing.
Flexible Synthesis of Phenanthrenes by a PtCl2‐Catalyzed Cycloisomerization Reaction. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
IFN-γ-activated monocytes weakly produce HIV-1 but induce the recruitment of HIV-sensitive T cells and enhance the viral production by these recruited T cells (2006)

The ability of macrophages to adapt to changing cytokine environments results in the dominance of a particular functional phenotype of macrophages, which would play a significant role in HIV pathogenesis. In comparison with untreated macrophages (M0), we examined the role of macrophages derived from IFN-gamma-activated monocytes (M1) in the HIV spread. We show that M0 and M1 bind with the same efficiency HIV-1 with a predominant role of C-type lectins in the R5-HIV attachment and of the heparan sulfate proteoglycans in the X4-HIV attachment. Despite similar levels of R5- and X4-HIV DNA, M1 replicates and weakly transmits the virus to activated T cells by releasing CXCR4- and CCR5-interacting chemokines. The blockade of dendritic cell-specific ICAM-3-grabbing nonintegrin expressed on M1 by mAb does not interfere with the viral transfer. Uninfected M1 recruits HIV-sensitive T cells efficiently and releases soluble factors, enhancing the viral production by these recruited cells. This study highlights the role of IFN-gamma to induce a population of macrophages that archive HIV-1 within a latent stage and cause the persistence of the virus by favoring the recruitment of T cells or enhancing the viral replication in infected CD4(+) T cells.
Severe Weather Effects on Water Quality in Central Arizona (2015)

Extreme weather events affect surface water supplies. Water quality measurements in Central Arizona were used to quantify changes in dissolved organic carbon (DOC) and turbidity following dust storms, floods, and drought‐associated wildfires. This article describes specific extreme events, quantifies changes in DOC and turbidity, and discusses the effects of water quality changes on treatment processes and public perceptions of water quality. Study findings show a co‐occurrence of some dust storm events (high particulate matter) and increased surface water turbidity, attenuation of high DOC loads following upper watershed storm events, significant increases in total organic carbon and turbidity following severe flooding in 2005, and differing effects of upland and lowland wildfires on water quality. Finally, a means to mitigate these effects on both perceived and actual water quality by integrating information from radar systems, stream gauge readings, and online water quality analyzers is suggested.
Isoform‐Specific Effects of Apolipoproteins E2, E3, and E4 on Cerebral Capillary Sequestration and Blood‐Brain Barrier Transport of Circulating Alzheimer's Amyloid β (1997)

Cerebral capillary sequestration and blood-brain barrier (BBB) permeability to apolipoproteins E2 (apoE2), E3 (apoE3), and E4 (apoE4) and to their complexes with sA beta(1-40), a peptide homologous to the major form of soluble Alzheimer's amyloid beta, were studied in perfused guinea pig brain. Cerebrovascular uptake of three apoE isoforms was low, their blood-to-brain transport undetectable, but uptake by the choroid plexus significant. Binding of all three isoforms to sA beta(1-40) in vitro was similar with a K(D) between 11.8 and 12.9 nM. Transport into brain parenchyma and sequestration by BBB and choroid plexus were negligible for sA beta(1-40)-apoE2 and sA beta(1-40)-apoE3, but significant for sA beta(1-40)-apoE4. After 10 min, 85% of sA beta(1-40)-apoE4 taken up at the BBB remained as intact complex, whereas free sA beta(1-40) was 51% degraded. Circulating apoE isoforms have contrasting effects on cerebral capillary uptake of and BBB permeability of sA beta. ApoE2 and apoE3 completely prevent cerebral capillary sequestration and blood-to-brain transport of sA beta(1-40). Conversely, apoE4, by entering brain microvessels and parenchyma as a stable complex with sA beta, reduces peptide degradation and may predispose to cerebrovascular and possibly enhance parenchymal amyloid formation under pathological conditions.
Aging rate of low voltage transformer for a high penetration of Plug-in Hybrid Electric Vehicles (PHEVs) (2012)

In the coming years, the Plug-in Hybrid Electric Vehicles (PHEVs) will strongly penetrate in the French car fleet. This needs to estimate their impact on each element of the distribution electric grid. Based on house and transformer Daily Loads Profiles (DLPs) model's generator and probabilistic algorithms of PHEVs connections, this paper proposes the VTR_PHEV index to calculate the aging rate caused by the integration of PHEVs correlated with the load rate without PHEVs of MV/LV transformer. It is shown that aging rate of the transformer is quadratic in presence of PHEVs.
T cells support osteoclastogenesis in an in vitro model derived from human multiple myeloma bone disease: the role of the OPG/TRAIL interaction (2004)

The development of multiple myeloma (MM) bone disease is mediated by increased number and activity of osteoclasts (OCs). Using an in vitro osteoclastogenesis model consisting of unstimulated and unfractionated peripheral blood mononuclear cells (PBMCs) from patients with MM, we showed that T cells support the formation of OCs with longer survival. Different from T-cell-depleted MM PBMC cultures, exogenous macrophage-colony stimulating factor (M-CSF) and receptor activator of nuclear factor-kappaB ligand (RANKL) were necessary for the formation of OCs; however, they did not exhibit longer survival. We found up-regulated production of RANKL, osteoprotegerin (OPG), and TNF-related apoptosis-inducing ligand (TRAIL) by fresh MM T cells. Despite high OPG levels, the persistence of osteoclastogenesis can be related to the formation of the OPG/TRAIL complex demonstrated by immunoprecipitation experiments and the addition of anti-TRAIL antibody which decreases OC formation. OCs overexpressed TRAIL decoy receptor DcR2 in the presence of MM T cells and death receptor DR4 in T-cell-depleted cultures. In addition, increased Bcl-2/Bax (B-cell lymphoma-2/Bcl2-associated protein X) ratio, following Bcl-2 up-regulation, was detected in OCs generated in the presence of T cells. Our results highlight that MM T cells support OC formation and survival, possibly involving OPG/TRAIL interaction and unbalanced OC expression of TRAIL death and decoy receptors.
Improved Private Set Intersection against Malicious Adversaries. (2016)

Private set intersection (PSI) refers to a special case of secure two-party computation in which the parties each have a set of items and compute the intersection of these sets without revealing any additional information. In this paper we present improvements to practical PSI providing security in the presence of malicious adversaries.
Structural characterization of monoclonal antibodies targeting C-terminal Ser404 region of phosphorylated tau protein. (2019)

Targeting tau with immunotherapies is currently the most common approach taken in clinical trials of patients with Alzheimer's disease. The most prominent pathological feature of tau is its hyperphosphorylation, which may cause the protein to aggregate into toxic assemblies that collectively lead to neurodegeneration. Of the phospho-epitopes, the region around Ser<sup>396</sup>/Ser<sup>404</sup> has received particular attention for therapeutic targeting because of its prominence and stability in diseased tissue. Herein, we present the antigen-binding fragment (Fab)/epitope complex structures of three different monoclonal antibodies (mAbs) that target the pSer<sup>404</sup> tau epitope region. Most notably, these structures reveal an antigen conformation similar to a previously described pathogenic tau epitope, pSer<sup>422</sup>, which was shown to have a β-strand structure that may be linked to the seeding core in tau oligomers. In addition, we have previously reported on the similarly ordered conformation observed in a pSer<sup>396</sup> epitope, which is in tandem with pSer<sup>404</sup>. Our data are the first Fab structures of mAbs bound to this epitope region of the tau protein and support the existence of proteopathic tau conformations stabilized by specific phosphorylation events that are viable targets for immune modulation.
Detection diversity of multiantenna spectrum sensors (2011)

In the context of spectrum sensing, we investigate the performance of detectors equipped with M antennas (co-located or distributed) under Rayleigh fading, in terms of detection diversity. Rather than the high-SNR concept of diversity order common in the communications literature, we adopt the notion recently advocated by Daher and Adve in the radar community: the slope of the average probability of detection (P̅ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> ) vs. SNR curve at P̅ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> = 0.5. This definition is well suited to spectrum sensing, which invariably deals with low SNR levels. It is shown that the diversity order grows as M for an optimal centralized detector having access to all observations, whereas for the two distributed schemes considered (the multiantenna energy detector and the OR detector) it grows no faster than √M.
Recombinant Production of the Amino Terminal Cytoplasmic Region of Dengue Virus Non-Structural Protein 4A for Structural Studies (2014)

Small molecules targeting amphipathic helices in the related Hepatitis C virus were shown to inhibit viral replication, representing a new class of antiviral drugs. These findings highlight the need for an efficient procedure that provides large quantities of the amphipathic helix containing NS4A peptides. The double tag strategy presented in this manuscript answers these needs yielding amounts that are sufficient for comprehensive biophysical and structural studies, which might reveal new drug targets.
Abstract 3712: Proliferative and invasive colorectal tumors in pet dogs provide unique insights into human colorectal cancer (2019)

Abstract Spontaneous tumors in pet dogs represent a valuable but undercharacterized cancer model. To better use this resource, we performed an initial global comparison between proliferative and invasive colorectal tumors from 20 canine cases and evaluated their molecular homology to human colorectal cancer (CRC). We sequenced 15 canine intestinal samples for WGS and 26 for RNA-seq. We investigated alterations in the genome and transcriptome, using state-of-the-art analysis tools. We aslso investigated their microbiome, by mapping WGS and RNA-seq read pairs that could not be placed onto the canine genome to two microbial genome databases: The Human Microbiome Project database and all bacterial genomic sequences. We performed the same analysis with TCGA (The Cancer Genome Atlas) colon cancer data. Based on our analysis, proliferative canine tumors harbor overactivated WNT/β-catenin pathways and recurrent CTNNB1 (β-catenin) mutations S45F/P, D32Y and G34E. Invasive canine tumors harbor prominent fibroblast proliferation and overactivated stroma. Both groups have recurrent TP53 mutations. We observed three invasion patterns in canine tumors: collective, crypt-like and epithelial-mesenchymal transition (EMT). We detected enriched Helicobacter bilis and Alistipes finegoldii in proliferative and crypt-like tumors, but depleted mucosa-microbes in the EMT tumor. Additionally, guided by our canine findings, we classified 79% of 478 human colon cancers from TCGA into four subtypes: primarily proliferative, or with collective, crypt-like or EMT invasion features. Their molecular characteristics match those of canine tumors. We showed that consensus molecular subtype 4 (mesenchymal) of human CRC should be further divided into EMT and crypt-like subtypes, which differ in TGF-β activation and mucosa-microbe content. Our canine tumors share the same pathogenic pathway as human CRCs. Dog-human integration identifies three CRC invasion patterns and improves CRC subtyping. Citation Format: Jin Wang, Tianfang Wang, Yanfang Sun, Yuan Feng, William C. Kisseberth, Carolyn J. Henry, Irene Mok, Susan E. Lana, Kevin Dobbin, Nicole Northrup, Elizabeth W. Howerth, Shaying Zhao, Houjian Cai. Proliferative and invasive colorectal tumors in pet dogs provide unique insights into human colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3712.
Resorcinol-Templated Head-to-Head Photodimerization of a Thiophene in the Solid State and Unusual Edge-to-Face Stacking in a Discrete Hydrogen-Bonded Assembly (2014)

A head-to-head photodimerization of a β-substituted thiophene stacked face-to-face in the solid state using a ditopic hydrogen-bond-donor template is reported. The face-to-face stacking is attributed to contributions of intertemplate forces, which contrasts an assembly wherein the same thiophenes stack edge-to-face yet maintain a discrete hydrogen-bonded structure.
Chronic hyperammonemia impairs the glutamate–nitric oxide–cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo (1998)

The aim of this work was to assess whether ammonia concentrations similar to the increase found in the brain of hyperammonemic rats (100 microM), impair N-methyl-D-aspartate (NMDA) receptor-mediated signal transduction. We first measured glutamate neurotoxicity, which in these neurons is mediated by activation of NMDA receptors, as an initial parameter reflecting activation of NMDA receptor-mediated pathways. Long-term treatment of cultured neurons with ammonia prevents glutamate-induced neuronal death. The EC50 was 20 microM, and at 100 microM the protection was complete. The induction of the protective effect was not immediate, but took several hours. Treatment with 100 microM ammonia did not prevent a glutamate- or NMDA-induced rise of intracellular calcium. Ammonia impaired the glutamate-nitric oxide-cGMP (3',5'-cyclic guanosine monophosphate) pathway in a dose- and time-dependent manner. Glutamate-induced formation of cGMP was reduced by 42%, while activation of nitric oxide synthase was not affected. Ammonia reduced by 31% cGMP formation induced by S-nitroso-N-acetyl-penicillamine (SNAP), a NO-generating agent, confirming that the interference occurs at the level of guanylate cyclase activation by nitric oxide. To assess whether chronic moderate hyperammonemia in vivo also impairs the glutamate-nitric oxide-cGMP pathway, we determined by in vivo brain microdialysis in freely moving rats the formation of cGMP induced by NMDA. In hyperammonemic rats, the formation of cGMP induced by NMDA and SNAP was reduced by ca. 60 and 41%, respectively, indicating that chronic hyperammonemia in the animal in vivo also impairs the glutamate-nitric oxide-cGMP pathway. Impairment of this pathway can contribute to the neurological alterations found in hyperammonemia and hepatic encephalopathy.
Consequences of Depletion of Susceptibles for Hazard Ratio Estimators Based on Propensity Scores (2020)

We use simulated data to examine the consequences of depletion of susceptibles for hazard ratio (HR) estimators based on a propensity score (PS). First, we show that the depletion of susceptibles attenuates marginal HRs toward the null by amounts that increase with the incidence of the outcome, the variance of susceptibility, and the impact of susceptibility on the outcome. If susceptibility is binary then the Bross bias multiplier, originally intended to quantify bias in a risk ratio from a binary confounder, also quantifies the ratio of the instantaneous marginal HR to the conditional HR as susceptibles are depleted differentially. Second, we show how HR estimates that are conditioned on a PS tend to be between the true conditional and marginal HRs, closer to the conditional HR if treatment status is strongly associated with susceptibility and closer to the marginal HR if treatment status is weakly associated with susceptibility. We show that associations of susceptibility with the PS matter to the marginal HR in the treated (ATT) though not to the marginal HR in the entire cohort (ATE). Third, we show how the PS can be updated periodically to reduce depletion-of-susceptibles bias in conditional estimators. Although marginal estimators can hit their ATE or ATT targets consistently without updating the PS, we show how their targets themselves can be misleading as they are attenuated toward the null. Finally, we discuss implications for the interpretation of HRs and their relevance to underlying scientific and clinical questions. See video Abstract: http://links.lww.com/EDE/B727.
A Modulated Helical Nanofilament Phase (2013)

A new liquid crystal phase, denoted modulated helical nanofilament (HNF(mod)), is formed from a very simple class of biphenyl carboxylates lacking the benzylidene aniline moieties typically found in HNF mesogens. The HNF(mod) phase represents a novel kind of nanoparticle possessing stacked aromatic rings, with potential applications in organic electronics. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
ChemInform Abstract: Acylsilanes as Geminal Radical Acceptor/Radical Donor Equivalents in Tandem Cyclization/Addition Reactions. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.