gebhart/patrepeval huggingface dataset:
Enhanced light extraction efficiency from organic light emitting diodes by insertion of a two-dimensional photonic crystal structure (2004)

We studied the characteristics of organic light emitting diode (OLED) devices containing two-dimensional (2D) SiO2∕SiNx photonic crystal (PC) layers. The finite-difference time-domain (FDTD) method was employed for the design and analysis of the PC OLED. Based on the design parameters derived from the FDTD calculations, a 2D PC layer was introduced on the glass substrate of a typical OLED structure by two-step irradiated hologram lithography and reactive ion etching. Experiments showed that incorporation of the PC layer improved the light extraction efficiency by over 50% compared to the conventional OLED, without noticeable degradation in electrical characteristics, under typical operating conditions. This improvement originates from the liberation of the photons trapped in the high-index guiding layers.
Noninvasive Quantification of Human Nucleus Pulposus Pressure with Use of T1ρ-Weighted Magnetic Resonance Imaging (2008)

T1rho-weighted magnetic resonance imaging has a strong potential as a quantitative biomarker of the mechanical function of the nucleus pulposus and of disc degeneration.
Search for the direct production of charginos, neutralinos and staus in final states with at least two hadronically decaying taus and missing transverse momentum in pp collisions at s = 8 $$ \sqrt{s}=8 $$ TeV with the ATLAS detector (2014)

Results of a search for the electroweak associated production of charginos and next-to-lightest neutralinos, pairs of charginos or pairs of tau sleptons are presented. These processes are characterised by final states with at least two hadronically decaying tau leptons, missing transverse momentum and low jet activity. The analysis is based on an integrated luminosity of 20.3 fb(-1) of proton-proton collisions at root s = 8 TeV recorded with the ATLAS experiment at the Large Hadron Collider. No significant excess is observed with respect to the predictions from Standard Model processes. Limits are set at 95% confidence level on the masses of the lighter chargino and next-to-lightest neutralino for various hypotheses for the lightest neutralino mass in simplified models. In the scenario of direct production of chargino pairs, with each chargino decaying into the lightest neutralino via an intermediate tau slepton, chargino masses up to 345 GeV are excluded for a massless lightest neutralino. For associated production of mass-degenerate charginos and next-to-lightest neutralinos, both decaying into the lightest neutralino via an intermediate tau slepton, masses up to 410 GeV are excluded for a massless lightest neutralino.
Reply to From Frailty to Gerastenia (2019)

This letter comments on the letter by Strandberg et al .
The performance of crossbar-based binary hypercubes (1995)

Wormhole routing is an attractive routing technique offering low latency communication without the need to buffer an entire packet in a single node. A new queueing-theoretic model for obtaining throughput and latency of binary hypercubes supporting wormhole routing is developed here. The model is very accurate in predicting the performance of an actual multicomputer over a range of network sizes, packet lengths, and input port priority mappings. Utilizing the model, the performance of networks with identical topologies but different node architectures is estimated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Advances in Targeting Voltage‐Gated Sodium Channels with Small Molecules (2012)

Blockade of voltage-gated sodium channels (VGSCs) has been used successfully in the clinic to enable control of pathological firing patterns that occur in conditions as diverse as chronic pain, epilepsy, and arrhythmias. Herein we review the state of the art in marketed sodium channel inhibitors, including a brief compendium of their binding sites and of the cellular and molecular biology of sodium channels. Despite the preferential action of this drug class toward over-excited cells, which significantly limits potential undesired side effects on other cells, the need to develop a second generation of sodium channel inhibitors to overcome their critical clinical shortcomings is apparent. Current approaches in drug discovery to deliver novel and truly innovative sodium channel inhibitors is next presented by surveying the most recent medicinal chemistry breakthroughs in the field of small molecules and developments in automated patch-clamp platforms. Various strategies aimed at identifying small molecules that target either particular isoforms of sodium channels involved in specific diseases or anomalous sodium channel currents, irrespective of the isoform by which they have been generated, are critically discussed and revised.
Tumor hypoxia is independent of hemoglobin and prognostic for loco-regional tumor control after primary radiotherapy in advanced head and neck cancer (2004)

There is evidence that tumor hypoxia adversely affects loco-regional tumor control and survival in head and neck cancer. The aim of the current study was to compare pretreatment tumor oxygenation measured by Eppendorf pO2 electrodes with known prognostic factors in advanced head and neck tumors after definitive radiotherapy, and to evaluate the prognostic significance of these parameters on loco-regional tumor control. Sixty-seven patients, median age 56 years (22-82), all with primary stage III-IV squamous cell carcinoma were available for survival analysis. Tumor oxygenation was described as the fraction of pO2 values < or = 2.5 mmHg (HP2.5) and the median tumor pO2. By regression analysis HP2.5 was independent of known prognostic factors including stage, pretreatment hemoglobin (Hb) and the largest tumor diameter at the site of pO2 measurement. By Kaplan-Meier analysis loco-regional tumor control at 5 years was in favor of less hypoxic tumors using either HP2.5 or median tumor pO2 as descriptors and stratifying by the median values. Also, Hb was prognostic of loco-regional tumor control at 5 years using the median value as cut off. HP2.5 as continuous parameter was highly significant for loco-regional tumor control in a multivariate analysis. In conclusion both HP2.5 and total Hb were prognostic for loco-regional tumor control, but HP2.5 as continuous variable was independently the strongest prognostic indicator for loco-regional tumor control after definitive primary radiotherapy in advanced head and neck tumors.
Sphere Packing Optimization and EXIT Chart Analysis for Multi-Dimensional QAM Signaling (2009)

We investigate on multi-dimensional QAM constellations optimized by sphere packing with the known densest lattices. We propose a greedy design method assisted by the sphere detection. It is demonstrated that the optimized constellations can significantly increase the squared minimum distance in comparison to the conventional QAM constellations. In addition, we analyze the optimized QAMs through the use of an extrinsic information transfer (EXIT) chart for iterative decoding.
High-Definition MPEG-4 AVC Traffic Analysis and Bandwidth Prediction (2008)

In this paper, we propose and evaluate the accuracy of two new MPEG-4 AVC video traffic models. The first predicts the size of the B-frames of MPEG-4 AVC compressed video. The second predicts the size of the group of pictures (GOP) of the MPEG-4 AVC compressed video. We also propose an enhancement to these models using a new scene change detector metric. These traffic models can be employed by a network scheduler to provision MPEG-4 AVC video bandwidth efficiently.
Stable poly(methyl methacrylate‐co‐divinylbenzene) microspheres via precipitation polymerization (2005)

Stable poly(MMA-co-DVB) microspheres were prepared by precipitation polymerization using acetonitrile as the main medium under various polymerization conditions including monomer and initiator concentrations.
Supplementary Table 6 from Integrative Genomic Analysis Implicates Gain of <i>PIK3CA</i> at 3q26 and <i>MYC</i> at 8q24 in Chronic Lymphocytic Leukemia (2023)

&lt;p&gt;XLS file, 1603KB.&lt;/p&gt;
Effective treatment and decolonization of a dog infected with carbapenemase (VIM‐2)‐producing Pseudomonas aeruginosa using probiotic and photodynamic therapies (2019)

Combined use of aPDT and probiotics could be a promising therapeutic strategy for treatment of superficial infections produced by carbapenem-resistant bacteria, while avoiding recurrent infection due to intestinal bacterial carriage of these multidrug-resistant pathogens.
SYNTHESIS AND THERMAL PROPERTIES OF A POLYSULFONIUM SALT WITH A COMB-LIKE STRUCTURE (2001)

Click to increase image sizeClick to decrease image size ACKNOWLEDGMENTS This work was partially supported by a Grant-in-Aid for Scientific Research (No. 11650878) from the Ministry of Education, Science, Sports and Culture, Japan. E. T. is a CREST Investigator for the Japan Science and Technology Corporation (JST).
Lithium Ion Conduction in Diblock Polymer Electrolyte with Tethered Anion (2021)

Abstract Solid polymer electrolyte (SPE) may provide a path for next generation high‐performance, hazard‐free lithium ion batteries. However, the low lithium ion transference number (t Li+ ) and electrolyte conductivity limit device performance. In this study, a diblock copolymer with a polycarbonate first block and poly(sulfonated styrene) second block has been synthesized and characterized for conductivity and shows improved t Li+ . The low dissociation of lithium salts from the tethered sulfonate anion was overcome by incorporating plasticizers. The diblock SPE material had room temperature conductivity of up to 1.95 ⋅ 10 −6 S/cm, and lithium transference number of up to 0.83 with the tethered sulfonate anion.
BindingSite-AugmentedDTA: enabling a next-generation pipeline for interpretable prediction models in drug repurposing (2023)

While research into drug-target interaction (DTI) prediction is fairly mature, generalizability and interpretability are not always addressed in the existing works in this field. In this paper, we propose a deep learning (DL)-based framework, called BindingSite-AugmentedDTA, which improves drug-target affinity (DTA) predictions by reducing the search space of potential-binding sites of the protein, thus making the binding affinity prediction more efficient and accurate. Our BindingSite-AugmentedDTA is highly generalizable as it can be integrated with any DL-based regression model, while it significantly improves their prediction performance. Also, unlike many existing models, our model is highly interpretable due to its architecture and self-attention mechanism, which can provide a deeper understanding of its underlying prediction mechanism by mapping attention weights back to protein-binding sites. The computational results confirm that our framework can enhance the prediction performance of seven state-of-the-art DTA prediction algorithms in terms of four widely used evaluation metrics, including concordance index, mean squared error, modified squared correlation coefficient ($r^2_m$) and the area under the precision curve. We also contribute to three benchmark drug-traget interaction datasets by including additional information on 3D structure of all proteins contained in those datasets, which include the two most commonly used datasets, namely Kiba and Davis, as well as the data from IDG-DREAM drug-kinase binding prediction challenge. Furthermore, we experimentally validate the practical potential of our proposed framework through in-lab experiments. The relatively high agreement between computationally predicted and experimentally observed binding interactions supports the potential of our framework as the next-generation pipeline for prediction models in drug repurposing.
Effect of Height and Radius(h/r)Ratio of Micro Lens Array Pattern on the Light Extraction of OLEDs (2011)

In this paper we discussed the effect of micro lens array(MLA) pattern fabricated on the glass substrate of organic light emitting diode(OLED) for improvement of light extraction efficiency. The MLA patterns were formed by combination of photolithography and thermal reflow method and its effect on light extraction efficiency form OLED device was examined.
The Role of Tribofilm Evolution on Tribological Behaviour of Ti3SiC2 Ceramic (2005)

The Ti3SiC2 compound is a thermodynamically stable nano-layered ternary carbide, that belongs to a family of over 50 ternary carbides and nitrides, so-called MAX phases. These phases are a new class of solids that possess a unique combination of properties: they are readily machinable, relatively soft for ceramics, but elastically stiff, and electrically and thermally conductive. However, only very few studies are dedicated to their tribological behavior. This paper presents some results on the tribological behavior of Ti3SiC2. During dry sliding on a Ti3SiC2 plane, a first regime of low friction and mild wear can be observed, with the build-up of a tribofilm on the counterface. Then, while in an apparently steady state, the tribological behavior suddenly turns to higher friction and severe wear of both counterfaces. Combining friction experiments and topographical observations of contacting surfaces during the first regime, we propose some explanations for such drastic transition in tribological behavior. While tribofilm thickness and roughness stabilize in the mild wear regime, the covering of the ball surface still increases. Thus, matter accumulation on the ball finally leads to seizure of the contact.
Chapter Four - Inhibitors of enzymes in the electron transport chain of Mycobacterium tuberculosis (2019)

The increasing prevalence of drug resistant tuberculosis has created an urgent need for new antibiotics with novel modes of action. New drug targets include various enzymes in the electron transport pathway that are critical for maintaining growth and survival of the causative bacterium. Following approval of the ATP synthase inhibitor bedaquiline, a large number of compounds with activity against these enzymes have been identified, and a few drug candidates were recently developed that are close to or have already commenced clinical trials. Such progress is indeed promising, although the predominant focus on just three targets (NADH dehydrogenase-2, QcrB in the cytochrome bc1-aa3 supercomplex, and ATP synthase) may need to be reconsidered in light of recent findings. In this chapter, we briefly review the role of each enzyme and summarize the key results for each inhibitor class.
Ferroelectric Properties of 1 mol% Mg-Doped Stoichiometric Lithium Niobate (2007)

We investigated the ferroelectric properties of 1 mol% Mg-doped stoichiometric lithium niobate (Mg:SLN), which is a promising material for use as a high-efficiency quasi-phase-matching (QPM) wavelength converter. The ferroelectric properties of Mg:SLN used for fabricating QPM devices have not been clarified yet. In our first experiment, the polarization–electric field (P–E) hysteresis loop in Mg:SLN was measured and its coercive field and spontaneous polarization were obtained. By measuring the P–E hysteresis loop, we investigated the dynamic properties and found a dependence of the coercive field on the slope rate of the electric field. Moreover, we obtained the "zero-velocity field" at which domain wall movement starts.
Short-pulsed Nd:YAG/Cr4+:YAG passively Q-switched microchip lasers (2003)

Passively Q-switched Nd: YAG/Cr4+:YAG microchip lasers have demonstrated pulse widths <150 ps. For short-pulsed operation, the pulse width is dependent on the Nd concentration and is correlated with the maximum pulse rate achievable before thermal runaway.
Combined Carotid Endarterectomy and Coronary Artery Bypass in a Community Hospital (1993)

A study examining combined carotid endarterectomy and coronary artery bypass (CAB) outside the metropolitan or university hospital setting was performed. Over a 5-year period, 52 patients underwent carotid endarterectomy and CAB under a single anesthetic. Twenty-two patients (42%) had unstable angina and 23 (44%) had previous neurologic symptoms. There were two postoperative strokes (4%), one ipsilateral and one contralateral to the endarterectomy site. No ipsilateral neurologic events occurred after discharge (mean follow-up 25 months). There were four deaths (8%), all of which were cardiac related. Three of the four deaths were in patients with a recent history of congestive heart failure, a subgroup with a high mortality rate (three of seven; 43%). Over the same period, 2421 patients underwent CAB alone with stroke and mortality rates of 1.4 and 2.0% respectively, while 344 patients had carotid endarterectomy alone with stroke and mortality rates of 0.6 and 0.6% respectively. It is concluded that the combined procedure can be performed in a community setting with morbidity and mortality rates similar to those for major centers. Although stroke and mortality rates for the combined procedure were higher than those for the isolated operations, this group has a high incidence of cardiac symptoms, including unstable angina and congestive heart failure. Patients with recent congestive heart failure had the highest mortality rate of any subgroup and these patients should be carefully examined with regard to selection for the combined procedure.
Effects of FFT coefficient quantization on sinusoidal signal detection (2003)

Detection of a sinusoid of unknown frequency in wideband noise is performed efficiently by the FFT (fast Fourier transform). The detector performs a hypothesis test on the magnitude of the FFT output. When the FFT is implemented, error due to arithmetic roundoff coefficient quantization limits the accuracy of the transform and degrades the detection performance. When the FFT is used as a detector of an unknown sinusoidal signal, the coefficient quantization error is significant and increases with the FFT length. The decimation is analyzed in time for a radix-2 FFT. The FFT output error is defined to be the maximum magnitude of the difference between the true FFT and FFT computed with the quantized coefficients. An upper bound on the error is derived by a deterministic analysis and is verified to be close to the actually measured error. Using the functional form of the bound and scaling it to fit the measured error, an empirical formula for the error is derived. The probability of detection of the quantized-coefficient FFT is computed using the empirical error formula. The probability of detection curves is presented as a function of the FFT length. Simulations indicate that when a sufficient number of bits is used to quantize the coefficients, the probability of detection does not significantly degrade.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Unsuspected viral infection in embryonic bone rudiments. (1978)

Free accessAbstractFirst published online January 5, 2017Unsuspected viral infection in embryonic bone rudiments.D J Simmons and A J KahnView all authors and affiliationsVolume 26, Issue 1https://doi.org/10.1177/26.1.202649
Correction to Discovery of 3-Oxabicyclo[4.1.0]heptane, a Non-nitrogen Containing Morpholine Isostere, and Its Application in Novel Inhibitors of the PI3K-AKT-mTOR Pathway (2019)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Discovery of 3-Oxabicyclo[4.1.0]heptane, a Non-nitrogen Containing Morpholine Isostere, and Its Application in Novel Inhibitors of the PI3K-AKT-mTOR PathwayHeather Hobbs*Heather HobbsMore by Heather Hobbshttp://orcid.org/0000-0001-8474-9016, Gianpaolo BraviGianpaolo BraviMore by Gianpaolo Bravi, Ian CampbellIan CampbellMore by Ian Campbell, Maire ConveryMaire ConveryMore by Maire Convery, Hannah DaviesHannah DaviesMore by Hannah Davies, Graham InglisGraham InglisMore by Graham Inglis, Sandeep PalSandeep PalMore by Sandeep Pal, Simon PeaceSimon PeaceMore by Simon Peace, Joanna RedmondJoanna RedmondMore by Joanna Redmond, and Declan SummersDeclan SummersMore by Declan Summershttp://orcid.org/0000-0001-7181-8764Cite this: J. Med. Chem. 2019, 62, 19, 8880Publication Date (Web):September 25, 2019Publication History Published online25 September 2019Published inissue 10 October 2019https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01498https://doi.org/10.1021/acs.jmedchem.9b01498correctionACS PublicationsCopyright © 2019 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1652Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (205 KB) Get e-Alertsclose Get e-Alerts
A Rapid and Cost-Effective Laser Based Synthesis of High Purity Cadmium Selenide Quantum Dots (2015)

A rapid and cost effective method is developed to synthesize high purity cadmium Selenide (CdSe) quantum dots in acetone medium using second harmonic of Nd:YAG nanosecond pulsed laser of 532 nm wavelength. The thermal agglomeration due the nanosecond pulse duration of the laser was successfully eliminated by using unfocussed laser beam and thereby providing a favorable conditions for the synthesis of quantum dots having the grain size of 3 nm. The morphological and optical characterizations like XRD, HRTEM, optical absorption of the synthesized CdSe quantum dots, reveal that the material possesses the similar characteristics of the one synthesized through cumbersome wet chemical methods. Relative to the CdSe bulk material, the synthesized CdSe quantum dots showed a blue shift in the measured band gap energy from near infrared spectral region to visible region, making this material very attractive for many solar energy harvesting applications like photo-catalysis and solar cells.
IMPACT PERFORMANCE EVALUATION OF WORK ZONE TRAFFIC CONTROL DEVICES (2000)

The goal of this project and related previous projects is to provide traffic control devices for use in work zones that would perform satisfactorily when impacted by errant vehicles in accordance with national safety performance guidelines set forth in National Cooperative Highway Research Program (NCHRP) Report 350. The specific objective of this project is to test and evaluate additional work zone sign supports and barricades to determine those that would perform satisfactorily when impacted by errant vehicles at 0 degrees (head-on). This report consists of four chapters describing the performance of full-scale testing on work zone barricades. Chapter I introduces the problem, background, objectives and scope. Chapter II outlines the research approach of the project, including descriptions of the work zone traffic control devices tested, the crash test matrix, and the evaluation criteria. Results of the crash tests are presented in Chapter III. A summary of findings, conclusions, and recommendations is presented in Chapter IV.