gebhart/patrepeval huggingface dataset:
Supplementary Figure 1 from Neoadjuvant Enzalutamide Prior to Prostatectomy (2023)

&lt;p&gt;Residual cancer burden (RCB) from each patient in the (A) enza and (B) enza/dut/LHRHa arms.&lt;/p&gt;
76. PROTON RELAXATION ENHANCEMENT AND STABILITY OF NITROXIDE SPIN LABELS (1984)

McNamara, M. T M.D; Ehman, R. L. M.D; Couet, W.; Lovin, J. M.D., B.S; Sosnovsky, G Ph.D; Tozer, T. N. Ph.D; Eriksson, U. B.S; Revel, D. M.D; Wesbey, G. E. M.D.; Engelstab, B. L. M.D; Brasch, R. C. . M.D.
Phosphoramidite Chemistry for the Synthesis ofcycloSal-Pro-Nucleotides (1999)

An alternative synthesis of 3-methyl-cycloSal-nucleotides 3-6 using phosphoramidite chemistry is described. This protocol clearly shows advantages for the cycloSal-introduction into cytosine containing nucleoside analogues.
Neutronics and Thermal-Hydraulics Analysis of a Long Operational Life LMR for Lunar Surface Power (2012)

This paper presents the results of iterative neutronics and thermal-hydraulic design optimization of a liquid metal cooled reactor for lunar surface power. The reactor placed below grade on the lunar surface is capable of generating 1.0 MWth continuously for ~20 years without refueling. It satisfies subcriticality requirement for shutdown, during launch and when submerged in wet sand and flooded with seawater in the unlikely event of a launch abort accident. The 3-D thermal-hydraulic design ensures good flow distribution and cooling of UN fuel pins and adequate mixing in the exit duct.
Assessment of Gaussian-3 and density functional theories for a larger experimental test set (2000)

The G2/97 test set [J. Chem. Phys. 106, 1063 (1997)] for assessing quantum chemical methods used to predict thermochemical data is expanded to include 75 additional enthalpies of formation of larger molecules. This new set, referred to as the G3/99 test set, includes enthalpies of formation, ionization potentials, electron affinities, and proton affinities in the G2/97 set and 75 new enthalpies of formation. The total number of energies in the G3/99 set is 376. Overall, G3 theory has a mean absolute deviation of 1.07 kcal/mol for the G3/99 test set and does about as well for the new hydrocarbons and substituted hydrocarbons as it does for those in the G2/97 test. However, G3 theory has large deviations for several of the new nonhydrogen systems in the G3/99 test set such as SF6 and PF5. Part of the source of error is traced to the inadequate geometries used in G3 theory for these molecules. Other variations of G3 theory are also assessed such as G3(MP2), G3(MP3), and the versions of G3 theory using scaled energy terms instead of the higher level correction. These variations also do well for the larger hydrocarbons and substituted hydrocarbons, but fail for the same nonhydrogen systems as G3 theory. The density functional methods assessed in this study, including the hybrid B3LYP method, all have much larger deviations from experiment for the new enthalpies of formation in the expanded test set; the mean absolute deviation more than doubles compared to that for the enthalpies in the G2/97 test set. This is due to a cumulative effect of the errors in the larger molecules in the density functional methods.
Performance-energy trade-off exploration in dynamic data types for network applications (2006)

Demanding applications are introduced to networking field, asking simultaneously for high performance and low-energy consumption, requests more imperative in wireless networks. The dynamic nature of such applications makes the dynamic memory subsystem of an embedded system a critical contributing factor to the overall energy and execution time performance. This paper presents a novel aspect in designing dynamic data types in network applications. A systematic methodology, which is tool-supported and capable of manipulating different network traces, is proposed. Plethora of possible solutions, i.e. Pareto points, in terms of energy consumption, performance and memory size usage is achieved. Eventually, alternative optimal implementations, i.e. Pareto-optimal points can be extracted. Two real-life case studies (from NetBench suite) are studied and explored thoroughly. It is proved that up to 80% energy savings and up to 20% performance, comparing with two benchmarks' original implementation, can be accomplished. Furthermore, a plethora of trade-offs among the Pareto-optimal choices reach up to 52% for energy consumption and up to 13% for performance, are achieved.
TCP Throughput Optimized Handover Decisions (2005)

Abstract: We consider a mobile user in an environment characterized by a cellular network with whole coverage and isolated Wireless-LAN (WLAN) access points. Downloading a file from the Internet, the user is often confronted with the need to come to a decision whether to handover from the cellular system to a WLAN access point. For offthe-shelf Mobile-IP configurations we show that the overall performance of a handover to WLAN and back depends on two main parameters only. Estimating these parameters at entering the WLAN coverage lets us derive a handover decision based on the overall performance seen by the user. We show in simulation that this handover algorithm performs well in differentiating between beneficial and decremental handovers. 1.
A novel design for beamforming the Breakthrough Starshot laser array (2020)

We outline a laser array beam forming concept that is capable of meeting the laser power requirements of Breakthrough Starshot, a concept aimed at propelling spacecraft to extremely high velocities via laser radiation pressure. Our laser beam forming design offers solutions to the required laser power, optical radiance, beam steering, beam focusing, and atmospheric turbulence compensation specifications. The design consists of a large array of hexagonally close-packed optical modules. Each module contains a collimating lens illuminated by a single fiber from a coherent array of fiber amplifiers. Beam steering is accomplished by transverse micromotion of the fiber amplifier tip illuminating each collimating optic, coupled with a phase shift applied to each module by an electrooptic modulator. Overall array focus is performed by adjusting the transverse and longitudinal fiber positions of each module. Thus, by simply manipulating the position of the fiber feeds of each module and applying the appropriate phase shifts, the beam shape of the entire array can be conditioned to meet the focusing and tracking requirements of the Breakthrough Starshot concept. The same hardware can compensate for the atmospheric aberrations of piston, tilt, and quadratic curvature. For our strawman design, we calculate the overall Strehl ratio reduction of the entire array resulting from incomplete array fill factors, errors in the array phasing, finite laser bandwidth and atmospheric turbulence to be 0.36.
Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction (2020)

Primary resistance to CD19-directed chimeric antigen receptor T-cell therapy (CART19) occurs in 10% to 20% of patients with acute lymphoblastic leukemia (ALL); however, the mechanisms of this resistance remain elusive. Using a genome-wide loss-of-function screen, we identified that impaired death receptor signaling in ALL led to rapidly progressive disease despite CART19 treatment. This was mediated by an inherent resistance to T-cell cytotoxicity that permitted antigen persistence and was subsequently magnified by the induction of CAR T-cell functional impairment. These findings were validated using samples from two CAR T-cell clinical trials in ALL, where we found that reduced expression of death receptor genes was associated with worse overall survival and reduced T-cell fitness. Our findings suggest that inherent dysregulation of death receptor signaling in ALL directly leads to CAR T-cell failure by impairing T-cell cytotoxicity and promoting progressive CAR T-cell dysfunction. SIGNIFICANCE: Resistance to CART19 is a significant barrier to efficacy in the treatment of B-cell malignancies. This work demonstrates that impaired death receptor signaling in tumor cells causes failed CART19 cytotoxicity and drives CART19 dysfunction, identifying a novel mechanism of antigen-independent resistance to CAR therapy.<i>See related commentary by Green and Neelapu, p. 492</i>.
Segmented channel routing (1993)

Novel problems concerning routing in a segmented routing channel are introduced. These problems are fundamental to routing and design automation for field programmable gate arrays (FPGAs), a new type of electrically programmable VLSI. The first known theoretical results on the combinatorial complexity and algorithm design for segmented channel routing are presented. It is shown that the segmented channel routing problem is in general NP-complete. Efficient polynomial time algorithms for a number of important special cases are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Characterization of the third-harmonic radiation generated by intense laser self-formed filaments propagating in air (2005)

We perform laboratory experiments to study ultraviolet radiation generated by intense self-formed laser filaments produced by propagating high-power femtosecond laser pulses in air. The laser used in the experiment is a 0.5 TW Ti:sapphire system with the center wavelength at 800 nm. The observed ultraviolet emission occurs in the form of the third harmonic and frequency-upshifted radiation from the fundamental. We present direct characterization of the generated harmonic and frequency-upshifted radiation, including transverse imaging and spatially resolved spectral measurements.
Insights into the Crystal Structure of Halide Solid Electrolytes and Li Diffusion (2022)

Lithium halides with general formula Li 3 MX 6 (M = metals such as Y, In, Yb or Sc; X = Cl or Br) have attracted significant attention because of their promising room temperature conductivities and high oxidative stability [1] . Li-ion mobility in these halides is strongly affected by the synthesis method and parameters. In Li 3 YCl 6 with a hexagonal-close-packed ( hcp ) anion framework, the ionic conductivity is commonly observed to decrease with increased crystallinity. While in Li 3 YBr 6 with a face-centered-cubic ( fcc ) anion framework, the ionic conductivity increases with increased crystallinity. So far there is no clear explanation for such opposite trends in these two otherwise very similar crystal structures. Ab initio molecular dynamics (AIMD) simulation [2] suggested higher ionic conductivity and lower activation energy in Li 3 YCl 6 than inLi 3 YBr 6 , which also does not agree well with the experimental observation that Li 3 YBr 6 commonly shows higher conductivity than Li 3 YCl 6 . Above-mentioned unexplained observations and inconsistencies imply that likely some critical structural features of these halides that strongly impact ionic diffusion are not yet explored nor taken into consideration. Here, we report our recent findings in the crystal structure of Li 3 YCl 6 and Li 3 YBr 6 and the design, synthesis and electrochemical testing of a few new halide compounds designed based on the new findings. The crystal structures are investigated with using ex situ and in situ synchrotron X-ray diffraction (XRD) and neutron diffraction (ND). Our study [3] demonstrated that the discrepancies between simulated and experimental results in Li 3 YBr 6 -type structure is partly caused by the grain boundary. Through PDF data analysis, we provide experimental evidences of cation local ordering in ab plane and stacking fault along c- direction in Li 3 YBr 6 -type structure. The lower ionic conductivity in low crystallinity is owing to the blockage of Li diffusion channel along c -direction caused by the stacking fault. Moreover, a new tetrahedral Li-site is identified, which may be critical in understanding the Li diffusion behaviors. Via rationally tuning Li occupancies at the tetrahedral and octahedral sites, low Li diffusion barriers can be achieved, which is in consistence with theoretical calculation results. [1] T. Asano, A. Sakai, S. Ouchi, M. Sakaida, A. Miyazaki, S. Hasegawa, Advanced Materials 2018 , 30 , 1803075. [2] S. Wang, Q. Bai, A. M. Nolan, Y. Liu, S. Gong, Q. Sun, Y. Mo, Angewandte Chemie International Edition 2019 , 58 , 8039-8043. [3] Z. Liu, S. Ma, J. Liu, S. Xiong, Y. Ma, H. Chen, ACS Energy Letters 2021 , 6 , 298-304.
Dielectricproperties of graphene nanoplatelets filled LDPE (2016)

This work presents studies on electrical properties of nanocomposites of low density polyethylene (LDPE) filled with graphene nanoplatelets (GnP) of different content. As compared to pure LDPE, significant reductions of the conductivity are found for the composites at relatively low electric fields (<;20 kV/mm). A crossover effect is however seen at higher fields (>20 kV/mm), where a strongfield dependentnon-linear behavior dominates, yielding higher conduction currents that increase with increasing filler content. Results of investigations of dielectric response confirm the differences found in polarization currents during the measurements of dc conductivity.
Generating small, accurate acoustic models with a modified Bayesian information criterion (2007)

Although Gaussian mixture models are commonly used in acoustic models for speech recognition, there is no standard method for determining the number of mixture components. Most models arbitrarily assign the number of mixture components with little justification. While model selection techniques with a mathematical derivation, such as the Bayesian information criterion (BIC), have been applied, these criteria focus on properly modeling the true distribution of individual tied-states (senones) without considering the entire acoustic model; this leads to suboptimal speech recognition performance. In this paper we present a method to generate statistically-justified acoustic models that consider inter-senone effects by modifying the BIC. Experimental results in the CMU Communicator domain show that in contrast to previous strategies, the new method generates not only attractively smaller acoustic models, but also ones with lower word error rate.
ChemInform Abstract: A Reliable Synthesis of 3‐Amino‐5‐alkyl and 5‐Amino‐3‐alkyl Isoxazoles. (2013)

Abstract Reaction temperature and pH are the key factors that determine the regioselectivity of the process.
Supplementary Figure 1 from Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer (2023)

Supplementary Figure 1 from Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer
Laser modulated electron capture detection for gas chromatography (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLaser modulated electron capture detection for gas chromatographyRichard A. Keller and N. DovichiCite this: Anal. Chem. 1983, 55, 3, 543–549Publication Date (Print):March 1, 1983Publication History Published online1 May 2002Published inissue 1 March 1983https://pubs.acs.org/doi/10.1021/ac00254a029https://doi.org/10.1021/ac00254a029research-articleACS PublicationsRequest reuse permissionsArticle Views31Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Integration of a poisoning-free dual damascene CDO film stack for 90 nm & beyond low-k BEOL (2005)

In this paper we report on the successful integration of a 90nm low-k full VIA-first dual damascene process architecture using carbon-doped-oxide (CDO) and SiC etch-stop-layer (ESL). One of the key features of the integration scheme is that the effects of photoresist poisoning have been eliminated by optimization of the low-k (k < 3.0) film stack deposition process. The mechanisms underlying photoresist poisoning have been investigated through detailed partition studies. Electrical yield and reliability data will be shown to demonstrate the performance of the overall integration approach.
Security of Finger Prints with Video Watermarking Techniques Based On DWT and SVD (2021)

Abstract Content producers and service providers face highly important challenges in securing digital video content. As watermarking is an important copyright protection technology, this literature includes several methods of combining data into a multimedia component. Due to its increasing application, in recent watermark schemes, the Discrete Wavelet Transformation (DWT) is used. In this text we suggest a DWT and the SVDbased hybrid system. After the image is separated into four strips, we add SVD to each strip and adjust the specific values into the same detail. Modification at all frequencies allows a framework to be established that is consistent with a broad range of threats.
Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety (2009)

ClinicalTrials.gov Identifier: NCT00961454.
Protection of FeTi thin films using palladium coatings (1988)

The use of FeTi as a hydrogen storage material is hindered by surface decomposition of the alloy when exposed to hydrogen charging gases containing PPM levels of O2/H2O impurities. This study investigates the application of palladium coatings as barrier materials against these impurities in order to increase the effective lifetime of the alloy over numerous charge-discharge cycles. Palladium was chosen because it has excellent hydrogen transport properties and it is impermeable to impurities containing oxygen at the temperatures and pressures of interest. Two 10 nm FeTi thin-film specimens were prepared, one coated with an additional 5 nm Pd overlayer, and both samples exposed to identical annealing and reduction treatments. Conversion electron Mossbauer spectroscopy (CEMS) was used along with other analytical techniques (i.e. XPS and SIMS) to obtain chemical, magnetic and electronic information at the buried and exposed interfaces. CEMS demonstrated that the Pd coating prevented subsurface decomposition of FeTi.
Dynamic distortion characterization of multiport RF PAs using MTA-based multiport measurement setup (2010)

This paper presents a dynamic AM-AM and AM-PM characterization of multiport RF power amplifiers. These measurements have been enabled by the multiport MTA-based measurement setup proposed in this paper. The setup provides simple, accurate, and time saving mechanism for these kinds of dynamic distortion characterizations since it is able to perform the measurements of multiport PAs in a single measurement shot. Finally, the measurements performed using the developed measurement setup on multiport balanced amplifier are presented.
Pre-shipment Data-retention/Read-disturb Lifetime Prediction & Aftermarket Cell Error Detection & Correction by Neural Network for 3D-TLC NAND Flash Memory (2019)

This paper proposes 2 neural network (NN) techniques for 3D-TLC (Triple-Level Cell) NAND flash memory. 1) Predict data-retention/read-disturb lifetime for chip sorting during preshipment test. 2) Detect and correct errors in aftermarket. First, in pre-shipment test, Neural Network-based Lifetime Prediction (NNLP) predicts ECC decoding fail rate (EDFR) and estimates data-retention/read-disturb lifetime. Based on predicted lifetime, NNLP sorts NAND flash. Second, in aftermarket, Neural Network-based Error Detection (NNED) detects and corrects errors. NNED decreases bit-error rate (BER) by 81.4%.
The Effect of Initial Connector Insertions on Electrical Contact Resistance (2007)

This work attempts to quantify the effect of repeated initial connector insertions and roughness on electrical contact resistance. Experimental measurements show that the electrical contact resistance increases measurably with repeated insertions. They also show that with repeated insertions the connector spring is plastically deformed, thus causing the force closing the contact across the surfaces to decrease. A multi-scale rough surface contact model was used to estimate the actual electrical contact resistance (ECR) versus applied force curve of the connector. As expected, the multiscale ECR model predicts that the ECR will decrease with applied force. Since the contact force decreases with each insertion of the connector due to plastic deformation, the model will predict that the ECR will also increase with each insertion. When the added resistance from a measurable layer of tin oxide is included, the multiscale ECR model shows fairly good agreement with the experimental measurements.
Stabilization of Kerr-type mode locking in a polarization-maintaining erbium-fiber laser with a Faraday mirror (1994)

Ultrashort fiber pulse sources based on Kerr-type passive mode locking are currently the subject of an intense research effort1 since they can be assembled with standard fiber components and offer the possibility of producing pulses at the bandwidth limit of rare-earth fiber lasers2 with gigahertz repetition rates.3 However, any practical fiber-based ultrashort pulse source must be environmentally stable; this is just the requirement that most of the various suggested cavity designs fail to fulfill so far.
Deformation of a Polydomain, Smectic Liquid Crystalline Elastomer (1998)

A main-chain, polydomain, smectic liquid crystalline elastomer (LCE) was prepared by reacting the LC epoxy monomer, diglycidyl ether of 4,4‘-dihydroxy-α-methylstilbene, with the aliphatic diacid, sebacic acid. When deformed in uniaxial tension, a “polydomain-to-monodomain” transition took place leading to bulk, macroscopic orientation. With this process was associated a plateau in the nominal stress-versus-strain curve and a dramatic change in optical properties from opaque to translucent. Polarized optical microscopy showed that the transition took place by an elongation of the LC domains and a rotation of the local director orientations along the stress axis. The strain and orientation of the deformed samples were retained upon unloading, even after annealing above Tg for extended periods. Upon heating, the oriented LCEs disordered at the same temperature as the undeformed polydomains and “remembered” their original polydomain microstructure and sample dimensions when subsequently cooled from the isotropic state.