gebhart/patrepeval huggingface dataset:
Xetal-Pro (2010)

This paper presents Xetal-Pro SIMD processor, which is based on Xetal-II, one of the most computational-efficient (in terms of GOPS/Watt) processors available today. Xetal-Pro supports ultra wide V DD scaling from nominal supply to the sub-threshold region. Although aggressive V DD scaling causes severe throughput degradation, this can be compensated by the nature of massive parallelism in the Xetal family. The predecessor of Xetal-Pro, Xetal-II, includes a large on-chip frame memory (FM), which cannot operate reliably at ultra low voltage. Therefore we investigate both different FM realizations and memory organization alternatives. We propose a hybrid memory architecture which reduces the non-local memory traffic and enables further V DD scaling. Compared to Xetal-II operating at nominal voltage, we could gain more than 10× energy reduction while still delivering a sufficiently high throughput of 0.69 GOPS (counting multiply and add operations only). This work gives a new insight to the design of ultra-low energy SIMD processors, which are suitable for portable streaming applications.
Supplementary Table 4 from A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors (2023)

&lt;p&gt;Best Overall Response&lt;/p&gt;
Proposal of current control method of high‐speed AC motor system (2011)

Abstract In this paper, a current control method for a high‐speed AC motor system is proposed. In high‐speed driving operation, the current controller tends to lose stability because of the dead time caused by computational delay and electromagnetic coupling included in the AC motor model. The main purpose of the proposed method is reduction of the dead time on the current controller. The proposed method is based on model predictive control and optimization of the start timing. The effectiveness of the proposed method is confirmed by simulation results. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 176(1): 37–45, 2011; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/eej.21083
Inlet Flow Incidence Effects on the Thermal Performance of Showerhead Cooling in a Nozzle Vane Cascade (2019)

Abstract In the present paper, the influence of inlet flow incidence on the thermal performance of a film cooled linear nozzle vane cascade is assessed. Tests have been carried out on a cooled cascade, featuring a showerhead cooling system made of 4 rows of cylindrical holes. The cascade was tested by varying the inlet flow angle in the range ±20° at a high inlet turbulence intensity level (Tu1 = 9%) and at a constant inlet Mach number of 0.12. The thermal characterization of vane leading edge region was obtained through adiabatic film cooling effectiveness measurements. Vane load distributions supported the discussion of the results. Varying the incidence angle in either positive or negative angles, the thermal protection on the vane is reduced while the maximum protection happened at 0° incidence case.
Matrix isolation of silacyclopentadienes: UV-visible and IR spectra and photochemical interconversion (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMatrix isolation of silacyclopentadienes: UV-visible and IR spectra and photochemical interconversionValery N. Khabashesku, V. Balaji, Sergei E. Boganov, Oleg M. Nefedov, and Josef MichlCite this: J. Am. Chem. Soc. 1994, 116, 1, 320–329Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/ja00080a037https://doi.org/10.1021/ja00080a037research-articleACS PublicationsRequest reuse permissionsArticle Views516Altmetric-Citations81LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evolution of Coral Pigments Recreated (2004)

In proteins homologous to the green fluorescent protein (GFP), formation of red fluorescence requires three autocatalytic steps, whereas only two are needed for green fluorescence. Multiple red/green color diversification events in the GFP superfamily may reflect convergent evolution of the more complex three-step pathway. In the great star coral Montastraea cavernosa, a recreated common ancestor of green and red proteins turned out to be green, indicating that in this case red proteins evolved their color independently from most other homologous red proteins. Furthermore, red color appears to have evolved gradually by small incremental transitions.
N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors (2014)

The glycosidase inhibitory properties of synthetic C-alkyl and N-alkyl six-membered iminosugars have been extensively studied leading to therapeutic candidates. The related seven-membered iminocyclitols have been less examined despite the report of promising structures. Using an in house ring enlargement/C-alkylation as well as cross-metathesis methodologies as the key steps, we have undertaken the synthesis and biological evaluation of a library of fourteen 2C- and eight N-alkyl tetrahydroxylated azepanes starting from an easily available glucopyranose-derived azidolactol. Four, six, nine and twelve carbon atom alkyl chains have been introduced. The study of two distinct D-gluco and L-ido stereochemistries for the tetrol pattern as well as R and S configurations for the C-2 carbon bearing the C-alkyl chain is reported. We observed that C-alkylation of the L-ido tetrahydroxylated azepane converts it from an α-L-fucosidase to a β-glucosidase and β-galactosidase inhibitor while N-alkylation of the D-gluco iminosugar significantly improves its inhibition profile leading to potent β-glucosidase, β-galactosidase, α-L-rhamnosidase and β-glucuronidase inhibitors whatever the stereochemistry of the alkyl chain. Interestingly, the N-alkyl chain length usually parallels the azepane inhibitor potency as exemplified by the identification of a potent glucocerebrosidase inhibitor (Ki 1 μM) bearing a twelve carbon atom chain. Additionally, several C-alkyl azepanes demonstrated promising F508del-CFTR correction unlike the parent tetrahydroxyazepanes. None of the C-alkyl and N-alkyl azepanes did inhibit ER α-glucosidases I or II.
Effects of human ghrelin and the peptide analogues, BIM-28131 and BIM-28125, on body weight, food intake and body composition in a rat model of heart failure (2006)

Effects of a Protein Optimized Diet Combined with Moderate Resistance Training on the Postoperative Course in Older Patients with Hip Fracture
Replicating characteristics by SR lithography (1995)

Process optimization and pattern replication on various substrates by synchrotron radiation lithography was carried out to evaluate the problems for 0.15 micrometers level resists patters for 1-Gbit dynamic random access memory. It was found that the exposure latitude was rather restricted by the resist residue remaining between lines (scum) and the pattern collapse than the normally used +/- 10-percent critical dimensions. A simple Fresnel diffraction calculation including the phase-shifting effect and mask contrast showed that the occurrence of the scum was mainly determined by the optical images of x-rays, and could not be significantly improved by the resist process condition. We used the mask/wafer proximity gap of 20 micrometers to get a good optical image and 5000-angstrom resist thickness to suppress the pattern collapse. On the other hand, the replicating characteristics on the light element substrates were similar to that on the Si substrate, especially good on the SiN substrate, but the residues caused by secondary electrons ont he metal substrates and the catalytic reaction on the Pt substrate were observed. It was shown that protection layers could suppress those residues and serve a good pattern profile.
Liposomal vaccine delivery systems (2011)

The use of liposomes as vaccine delivery systems is evolving rapidly owing to the combined increase in technological advances and understanding of the immune system. Liposomes that contain and deliver immunostimulators and antigens are now being developed to target diseases that require stimulation of both humoral and cell-mediated immune responses. The CAF liposomal system, described in detail in this review, is one liposomal model that shows such flexibility.
Reaction Rates for the Chemiluminescence ofCypridinaLuciferin Analogues with Superoxide: A Quenching Experiment with Superoxide Dismutase (1991)

Reaction rate constants for superoxide with Cypridina luciferin analogues (CLAs), 2-methyl-6-phenyl- and 2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-ones (CLA and MCLA), and 2-methyl-6-[p-[2-[sodium 3-carboxylato-4-(6-hydroxy-3-xanthenon-9-yl)-phenylthioureylene]ethyleneoxy]phenyl]-3,7-dihydroimidazo[1,2-a]pyrazin-3-one (FCLA), were determined for the first time by using superoxide dismutase (SOD) for a quencher as 1.08 × 108, 2.54 × 108 and 8.5 × 107 M−1 sec−1 in pH 7.1 buffer solutions at 25°C.
Manipulation of autophagy by bacteria for their own benefit (2011)

Autophagy is the host innate immune system's first line of defense against microbial intruders. When the innate defense system recognizes invading bacterial pathogens and their infection processes, autophagic proteins act as cytosolic sensors that allow the autophagic pathway to be rapidly activated. However, many intracellular bacterial pathogens deploy highly evolved mechanisms to evade autophagic recognition, manipulate the autophagic pathway, and remodel the autophagosomal compartment for their own benefit. Here current topics regarding the recognition of invasive bacteria by the cytosolic innate immune system are highlighted, including autophagy and the mechanisms that enable bacteria to evade autophagy. Also highlighted are some selective examples of bacterial activities that manipulate the autophagic pathways for their own benefit.
Next‐generation sequencing of the intrahepatic antibody repertoire delineates a unique B‐cell response in HBV‐associated acute liver failure (2020)

Hepatitis B virus (HBV) is a major cause of acute liver failure (ALF) worldwide. While liver damage in classic acute hepatitis B is believed to be T-cell mediated, the pathogenesis of HBV-associated ALF remains largely unknown. Access to liver specimens from well-characterized patients with HBV-associated ALF provided us with the opportunity to perform next-generation sequencing (NGS) of the entire VH repertoires of IgM and IgG from the livers of four ALF patients, a control liver donor and a patient with chronic HBV infection. We found that ALF is not associated with expansion of specific B-cell lineages. However, NGS showed that the intrahepatic VH repertoires from ALF patients were characterized by the abundant presence of antibodies in germline configuration in contrast to their marginal prevalence in controls. Moreover, NGS identified a large number of VH genes in germline configuration with identical VDJ sequences in the IgM and IgG repertoires in all four ALF patients, indicating that isotype switch from IgM to IgG had occurred without somatic hypermutation. The results of this study indicate that the presence of intrahepatic antibodies in unmutated germline configuration is a broad phenomenon in the global antibody repertoire generated from total RNA derived from whole-liver tissue that is strongly associated with ALF, suggesting a major role of T cell-independent humoral immunity in the pathogenesis of ALF.
Fabrication study of single-mode optical fibers with P/F-doped cladding (1981)

In previous fabrication studies of silica-based single-mode optical fibers for long wavelength, glass compositions of Ge-doped core and pure silica cladding,1 P-doped cladding,2 and P/F-doped cladding3 were investigated. Among those three glass compositions, P/F-doped cladding is considered to be most promising because of lowered deposition temperatures of the cladding glass, which makes it possible to achieve low loss and long length. However, the reported loss value of 0.7 dB/km in Ref. 3 is not sufficiently low in comparison with those reported in Refs. 1 and 2.
Ultrasound imaging to track the advance of coagulation front in laser irradiated tissue (2002)

Several theoretical models have been developed to predict the advance of the coagulation front in a laser irradiated tissue. However, there exists a keen interest in obtaining experimental feedback methods to better understand and monitor the response of tissue to laser irradiation in surgical and therapeutic procedures, In this work, an attempt was made to track the advancement of the coagulation front in beef myocardium tissue using ultrasound imaging. An intravascular ultrasound probe was used to image tissue coagulation while being irradiated by a Nd:YAG laser. Image processing algorithms were developed to track the coagulation front automatically based on a sequence of ultrasound image frames. Parameters of a Gaussian function were employed to quantify the coagulation depth. All the algorithms were incorporated into a graphical-user-interface to allow a user-friendly and easy-to-use mechanism for computing the coagulation advancement. Histological information was then utilized to verify the validity of the coagulation depth. The results obtained demonstrate the feasibility of ultrasound imaging as a potentially viable tool for studying or monitoring laser-tissue interaction.
Regulation of a Human Cardiac Actin Gene Introduced Into Rat L6 Myoblasts Suggests a Defect in Their Myogenic Program (1986)

The rat myogenic cell line L6E9 induces skeletal but not cardiac alpha-actin mRNA upon fusion to form myotubes. However, when a human cardiac alpha-actin gene was introduced into L6E9 myoblasts, differentiation of the cells led to the accumulation of human gene transcripts in parallel with those derived from the endogenous skeletal alpha-actin gene. This result demonstrates that factors which direct rat myogenesis can regulate a muscle gene from another species and that the L6E9 cells may have a defect in their ability to activate endogenous cardiac actin gene expression.
Synthesis of Indazole‐N‐oxides via the 1,7‐Electrocyclization of Azomethine Ylides. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Catalytically Active Silica Nanoparticle-Based Supramolecular Architectures of Two Proteins – Cellobiose Dehydrogenase and Cytochrome c on Electrodes (2012)

Artificial nanobiomolecular architectures that follow natural examples in protein assembly become more and more important from basic and applied points of view. Our study describes the investigation on cellobiose dehydrogenase (CDH), cytochrome c (cyt c), and silica nanoparticles (SiNP's) for the construction of fully catalytically active supramolecular architectures on electrodes. We report on intraprotein, interprotein, and direct electron-transfer reaction cascades of cellobiose dehydrogenase and cytochrome c immobilized in multiple supramolecular layers. Carboxy-modified SiNP's are used to provide an artificial matrix, which enables protein arrangement in an electroactive form. Direct and interprotein electron transfer has been established for a two-protein system with CDH and cyt c in a layered architecture for the first time. We also highlight that the glycosylation of CDH and the silica nanoparticle size play key roles in the mode of operation in such a complex system. The response of the specific substrate, here lactose, can be tuned by the number of immobilized nanobiomolecular layers.
Inheritance of Bacillus thuringiensis Cry2Ab2 protein resistance in Helicoverpa zea (Lepidoptera: Noctuidae) (2020)

These results have significant implications for understanding the widespread field-evolved resistance of H. zea against Cry1 and Cry2 proteins in Bt corn and cotton and should be useful in developing effective IRM strategies for H. zea. © 2020 Society of Chemical Industry.
Inbreeding depression rates for six synthetic populations of maize (1991)

The objective of Inbreeding In maize (Zea mays L.) Is to develop pure lines that are used to repeatedly produce an elite hybrid. Inbreeding In maize is accompanied by a reduction In the mean phenotyplc value for most traits. This reduction in the mean is frustrating to the breeder whose goal is to develop higher yielding more vigorous lines. Any reduction in the mean is caused by an increased number of loci in an individual becoming identical by descent from a common ancestor. This genetic phenomena is known as inbreeding depression. Little empirical information was available to determine how inbreeding depression rates may have been changed by recurrent selection in maize populations. The objectives of this study were threefold: determine the relative inbreeding depression rates for 16 plant and ear traits in six synthetic maize populations; determine the relative merit of two distinctly different long-term recurrent selection programs in BSSS for changing inbreeding depression rates; and determine if the linear (additive) model explained the variation among the generation means for BSSS and BSCBl and the Improved populations BS13(S)C3, BSSS(R)C9, and BSCBl(R)C9. The population per se and seven bulked inbred subpopulations (S^ to S7) of BS13(S)C3, BSSS(R)C9, BSCB1(R)C9, BS26, BSCB1(R)C0, and BSSSCO were available for evaluation. Inbred lines B14 and B73 were Included to provide 50 entries for the study. The Inbred lines were developed from each population using a modified single seed descent procedure. Selection was not practiced during the inbreeding process so that allele
Mitochondrial Haplogroups and Control Region Polymorphisms in Age-Related Macular Degeneration: A Case-Control Study (2012)

It can be concluded that haplogroup J is a risk factor for AMD, whereas haplogroup H seems to be protective for AMD.
A Fast Method to Simulate the PDL Impact on Dual-Polarization Coherent Systems (2009)

Polarization-dependent loss (PDL) is regarded as a major distortion in dual-polarization coherent systems. Due to its statistical characteristics, a time-consuming Monte Carlo simulation is usually used to evaluate its penalty. In order to accelerate the simulation speed, a more rapid method, the reversed channel method, is proposed and verified. Compared with the Monte Carlo simulation, for example 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> iterations, simulation time is reduced from 200 h to 15 min, i.e. 800 times less, whereas the accuracy is not degraded. The reversed channel method also indicates that not only the accumulative PDL and amplified spontaneous emission levels but also their distribution profiles along the transmission line affect the system performance.
Rectification of Distorted Document Images Using Variants, Invariants and Normalization (2008)

Water stress is a major cause of yield loss in peanut cultivation. Melatonin seed priming has been used to enhance stress tolerance in several crops, but not in peanut. We investigated the impact of seed priming with melatonin on the growth, development, and drought tolerance of two peanut cultivars, TUFRunner™ '511', a drought tolerant cultivar, and New Mexico Valencia A, a drought sensitive cultivar. Peanut seed priming tests using variable rates of melatonin (0-200 μM), indicated that 50 μM of melatonin resulted in more uniform seed germination and improved seedling growth in both cultivars under non stress conditions. Seed priming with melatonin also promoted vegetative growth, as evidenced by higher whole-plant transpiration, net CO<sub>2</sub> assimilation, and root water uptake under both well-watered and water stress conditions in both cultivars. Higher antioxidant activity and protective osmolyte accumulation, lower reactive oxygen species accumulation and membrane damage were observed in primed compared with non-primed plants. Seed priming with melatonin induced a growth promoting effect that was more evident under well-watered conditions for TUFRunnner™ '511', whereas for New Mexico Valencia A, major differences in physiological responses were observed under water stress conditions. New Mexico Valencia A primed plants exhibited a more sensitized stress response, with faster down-regulation of photosynthesis and transpiration compared with non-primed plants. The results demonstrate that melatonin seed priming has significant potential to improve early establishment and promote growth of peanut under optimal conditions, while also improve stress tolerance during water stress.
Elucidating the Origin of Conformational Energy Differences in Substituted 1,3-Dioxanes:  A Combined Theoretical and Experimental Study (1996)

13C NMR spectroscopy, ab initio quantum mechanics, and molecular mechanics have been used to investigate the trans-4-(trifluoromethyl)-2,2,6-trimethyl-1,3-dioxane chair/twist-boat equilibrium. The molecular mechanics calculations were based upon the MM3 and AMBER force fields. A 6-31G basis set was used for the ab initio calculations, and MP2 correlation corrections were applied. Both the ab initio and AMBER molecular mechanics calculations are consistent with the (13)C NMR chemical shift differences for the trans-4-(trifluoromethyl)-2,2,6-trimethyl-1,3-dioxane conformers. The predicted chair to twist-boat equilibrium suggested by the MM3 calculations is not consistent with the experimental data. These results support the suggestion by Howard et al. (Howard, A. E.; Cieplak, P.; Kollman, P. A. J. Comput.Chem. 1995, 16, 243-261) on the critical role of electrostatic interactions in determining the chair/twist-boat equilibrium.
Terms Used in IPv6 over the TSCH mode of IEEE 802.15.4e (2018)

This document provides a glossary of terminology used in IPv6 over the
TSCH mode of IEEE 802.15.4e (6TiSCH). This document extends existing
terminology documents for Low-power and Lossy Networks.
Comparison of motion control loops for industrial applications (2003)

High-performance AC and DC industrial servomotor drives use standardized motion control algorithms. The algorithms are based on common feedback sensing methods (digital position measurement via encoders or resolvers) and a common assumption that the electromagnetic torque dynamics are substantially faster than the motion control dynamics desired. The vast majority of these motion control algorithms close the motion control loops in one of two ways: (1) an average velocity loop is cascaded with a position loop; or (2) multiple state variable loops are closed in parallel. If the state variable form is properly configured, the command tracking properties are virtually independent of the disturbance rejection properties. However, this controller would require a command for acceleration which is frequently not available. In this case some modified form of cascaded loop controller topology is often used. In this paper,the alternative methods for this case are explored and tuning guidelines developed based on both simulation and laboratory results.