gebhart/patrepeval huggingface dataset:
Experimental Verification of the Feasibility of the Cardiovascular Impedance Simulator (2009)

Mock circulatory systems (MCS) are often used for the development of cardiovascular devices and for the study of the dynamics of blood flow through the cardiovascular system. However, conventional MCS suffer from the repeatability, flexibility, and precision problems because they are typically built up with passive and linear fluidic elements such as compliance chamber, manual valve, and tube. To solve these limitations, we have developed an impedance simulator, comprised of a feedback-controlled positive displacement pump that is capable of generating analogous dynamic characteristics as the conventional fluidic elements would generate, thereby replacing the conventional passive fluidic elements that often cause problems. The impedance simulator is experimentally proven to reproduce the impedance of the various discrete elements, such as resistance and compliance of the cardiovascular system model, as well as the combined impedances of them.
Human respiratory syncytial virus reduces the number of cells in S-phase and increases GADD153 expression in HEp-2 cells (2009)

Human respiratory syncytial virus (HRSV) associated with bronchiolitis and asthma is known to replicate actively in ciliated epithelial cells. However, little is known about the influence of HRSV replication on the cell cycle. We found that HRSV infection of HEp-2 cells led to a reduction of the number of cells in S-phase, to an increase in the number of cells in G1-phase, together with an increase of GADD153 mRNA levels and GADD153 protein expression. These results implied that a shorter S-phase supported HRSV replication suggesting possible strategies for interfering with productive HRSV infection.
Optical neural network for real time face recognition (1992)

We describe a two layer optical network that is trained to recognize in real time ″Denk,″ who is a student in our group. The network is implemented with liquid crystal spatial light modulators for the neural planes and lithium niobate photorefractive crystals for the interconnections. The network has approximately 60,000 units at the input plane, 30 hidden units, and a single output unit. The network is trained with a video segment 1.5 min long, from which 180 frames were selected for learning. Specifically, each hidden unit was trained to respond to six frames. The trained network classified the rest of the training tape almost flawlessly. The system was then tested by presenting through a TV camera real time inputs of Denk and other members of our group. The system almost never mis-classifies other people as Denk and exhibits remarkable tolerance to changes in aspect, illumination, and facial expression.
Advanced DBC - Highly Reliable and Conductive Copper Ceramic Substrates (2016)

Abstract So far Direct Bonded Copper (DBC) substrates have been the standard for power electronics. They provide excellent electrical and thermal conductivity at low cost. Weaknesses of DBC technology are the inevitable warpage and the relatively low reliability under thermal cycling. The low reliability poses a significant hurdle in particular for automotive applications with high lifetime requirements. Thick Print Copper (TPC) substrates with low warpage and excellent reliability overcome these weaknesses, but also provide a reduced conductivity at a higher cost. We present two thick-film/DBC hybrid technologies which combine the best properties of DBC and TPC: excellent conductivity, low cost, reduced warpage and excellent reliability.
LRP and αvβ3mediate tPA activation of smooth muscle cells (2006)

Tissue-type plasminogen activator (tPA) regulates vascular contractility through the low-density lipoprotein-related receptor (LRP), and this effect is inhibited by plasminogen activator inhibitor type 1 (PAI-1). We now report that tPA-mediated vasocontraction also requires the integrin alphavbeta3. tPA-induced contraction of rat aortic rings is inhibited by the Arg-Gly-Asp (RGD) peptide and by monoclonal anti-alphavbeta3 antibody. tPA induces the formation of a complex between LRP and alphavbeta3 in vascular smooth muscle cells. The three proteins are internalized within 10 min, causing the cells to become refractory to the readdition of tPA. LRP and alphavbeta3 return to the cell surface by 90 min, restoring cell responsiveness to tPA. PAI-1 and the PAI-1-derived hexapeptide EEIIMD abolish the vasocontractile activity of tPA and inhibit the tPA-mediated interaction between LRP and alphavbeta3. tPA induces calcium mobilization from intracellular stores in vascular smooth muscle cells, and this effect is inhibited by PAI-1, RGD, and antibodies to both LRP and alphavbeta3. These data indicate that tPA-mediated vasocontraction involves the coordinated interaction of LRP with alphavbeta3. Delineating the mechanism underlying these interactions and the nature of the signals transduced may provide new tools to regulate vascular tone and other consequences of tPA-mediated signaling.
Axonal Amyloid Precursor Protein Expressed by Neurons in Vitro Is Present in a Membrane Fraction with Caveolae-like Properties (1996)

In cortical neurons differentiating in vitro, transmembrane amyloid precursor protein (APP) is distributed in two pools. Whereas the first pool is present in all cell compartments, the second pool is highly enriched in the axon and cell body. In an earlier study we demonstrated that this second pool, referred to as axonal-APP (Ax-APP), is present in the vicinity of the plasma membrane and colocalizes only partially with clathrin (Allinquant, B., Moya, K.L., Bouillot, C., and Prochiantz, A. (1994) J. Neurosci. 14, 6842-6854). In this report, using immunocytochemical and fractionation techniques we demonstrate that Ax-APP is present in microdomains enriched in the glypiated glycoprotein F3. The F3/Ax-APP microdomains are resistant to nonionic detergents and sediment at low density on a sucrose gradient. The two latter properties are reminiscent of those of caveolae, a type of plasmalemmal vesicle found in several cell types, but not previously described in the nervous system due to the absence of caveolin in neurons. The presence of Ax-APP in caveolae-like vesicles raises the possibility that APP serves as a transmembrane signaling molecule for GPI-linked glycoproteins. In addition, our data support new hypotheses on the endocytic pathways leading to the production of the amyloidogenic betaA4 peptide.
Ultrafast nonequilibrium spin dynamics in a ferromagnetic thin film (1998)

An ultrafast time-resolved magneto-optical pump probe is applied to study spin-relaxation processes in a ferromagnetic ${\mathrm{CoPt}}_{3}$ alloy film. Following spin-selective photoexcitation with circularly polarized femtosecond pulses, transient Kerr ellipticity tracks the evolution of the nonequilibrium spin system. We isolate two distinct processes: a subpicosecond component due to the relaxation of coherently spin polarized electrons, and a slower component (\ensuremath{\sim}10 psec) associated with the evolution of the thermalized spin distribution and the photoinduced transient magnetization.
Cross-Layer Design of Multicast in Fading: Network Coding and Asynchronous Subgradients (2010)

A cross-layer design along with an optimal resource allocation framework is formulated for wireless fading networks, where the nodes perform network coding. The aim is to jointly optimize end-to-end multicast rates, network code design variables, broadcast link flows, link capacities, average power consumption, and short-term power allocation policies. As in the conventional routing paradigm, the cross-layer optimization problem with network coding is non-convex in general. It is proved however, that dual decomposition is optimal so long as the fading at each wireless link is a continuous random variable. This result is leveraged to develop a subgradient algorithm for network control. The algorithm is asynchronous, whereby the dual updates at the physical layer can be affordably performed with a certain delay with respect to the resource allocation tasks in upper layers. Moreover, the long-term average values of multicast end-to-end rates, virtual flows, broadcast link flows, link capacities, and power consumption are shown to converge to near-optimal ones.
Pt-Embedded MoO[sub 3] Electrodes for Rechargeable Lithium Batteries (2007)

Effects of Pt nanoparticle incorporation into a thin film, which was prepared via cosputtering of a Pt and target, were investigated for a cathode electrode of the rechargeable Li batteries. The incorporation of the Pt with size of ca. formed a heterogeneous film morphology with nanophases of Pt and domains, leading to a better cyclic performance than the electrode of without Pt. These enhancements with Pt in the electrode could be ascribed to a combined effect of substantial decrease in the sheet resistance and amelioration of the mechanical stability of the film itself.
Prospective, Multicenter Clinical Trial of Everolimus as Primary Therapy in Waldenstrom Macroglobulinemia (WMCTG 09-214) (2016)

<b>Purpose:</b> Everolimus inhibits mTOR, a component of PI3K/AKT prosurvival signaling triggered by MYD88 and CXCR4-activating mutations in Waldenstrom macroglobulinemia.<b>Experimental design:</b> We evaluated everolimus in a prospective, multicenter study of 33 symptomatic, previously untreated Waldenstrom macroglobulinemia patients. Intended therapy consisted of everolimus (10 mg/day) until progression or unacceptable toxicity. Dose deescalation was permitted. The study was registered at www.clinicaltrials.gov (NCT00976248).<b>Results:</b> At best response, median serum IgM levels declined from 4,440 to 1,360 mg/dL (<i>P</i> < 0.0001), median hemoglobin rose from 10.8 to 12 g/dL (<i>P</i> = 0.001), and median bone marrow disease burden declined from 75% to 52.5% in serially biopsied patients. The ORR and major response rates were 72.7% and 60.6%, respectively. Among genotyped patients, nonresponders associated with wild-type MYD88 and mutated CXCR4 status. Median time to response was 4 weeks. Discordance between serum IgM levels and bone marrow disease burden was remarkable. With a median follow-up of 13.1 (range, 1.6-64.6 months), the median time to progression was 21 months for all patients and 33 months for major responders. Discontinuation of everolimus led to rapid serum IgM rebound in 7 patients and symptomatic hyperviscosity in 2 patients. Toxicity led to treatment discontinuation in 27% of patients, including 18% for pneumonitis.<b>Conclusions:</b> Everolimus is active in previously untreated Waldenstrom macroglobulinemia. IgM discordance is common, and treatment cessation can often lead to rapid serum IgM rebound. Pneumonitis also appears more pronounced in untreated versus previously treated Waldenstrom macroglobulinemia patients. The risks and benefits of everolimus should be carefully weighed against other primary Waldenstrom macroglobulinemia therapy options. <i>Clin Cancer Res; 23(10); 2400-4. ©2016 AACR</i>.
Laser Controlled Semiconductor Closing And Opening Switch (1988)

Optically controlled bulk semiconductor switches have the potential to replace plasma switches in applications where fast (nanosecond) response, remote control and fast recovery are important. A concept for an optically controlled closing and opening switch is presented, where laser radiation is not used to sustain the switch conductance, but to drive the switch into and out of the conductive state. The concept is based on photoexcitation of electrons and holes, respectively from deep centers. Photoconductance measurements on cadmium sulfide doped with copper (CdS:Cu) have proved the feasibility of using stimulated electron-hole recombination as mechanism for opening a semiconductor switch. Besides CdS:Cu, gallium arsenide (GaAs) doped with copper (Cu) and silicon (Si) is used as a switch material. The steady state and transient behavior of such a GaAs:Cu:Si switch has been modeled using a system of rate equations. From the calculations it is seen that an increase or decrease in conductivity by several orders of magnitude can be achieved with laser power in the range of MW/cm<sup>2</sup>. The theoretical results are compared with the actual performance of optically controlled GaAs:Cu:Si switches.
ChemInform Abstract: Asymmetric Synthesis of a Key 1α,25‐Dihydroxy‐Vitamin D3 Ring A Synthon. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Patient-specific coronary artery supply territory AHA diagrams (2009)

The American Heart Association proposed a 17-segment model for the segmentation of the left ventricle together with a mapping from each segment to a supplying coronary artery. This proposal is based on population averages. Several studies have confirmed the inaccuracy of this mapping due to large anatomical variations of the coronary arteries among individuals. Several proposals have been made for a different mapping between the 17 segments and the coronary arteries.
Dynamics of Globally Coupled Rotators with Multiplicative Noise (1998)

We study the dynamics of globally coupled rotator model with multiplicative noise concentrating on time-delay effect. It is shown that at a critical noise intensity the system undergoes a noise-induced transition and is split into clusters. Time-delayed interaction in the system affects the picture of the transition suppressing the clustering of the rotators and generates the switching phenomenon between the clusters. For some values of delay time the system has two stable steady states which show different dynamics. According to the initial condition the system evolves into one of the stable steady states. We discuss the nature of the transition and the switching phenomenon in the system.
Efficacy and Safety of the 3-Month Formulation of Paliperidone Palmitate vs Placebo for Relapse Prevention of Schizophrenia (2015)

clinicaltrials.gov Identifier:NCT01529515.
Involvement of a Pit‐1 Binding Site in the Regulation of the Rat Somatostatin Receptor 1 Gene Expression (1998)

It was shown that at least four regions in the 2.2 kb upstream DNA of the sst1 gene are important for the cell type-specific promoter activity in GH3 and RIN cells. Moreover, the 48 bp region located between -165 to -117 harbors positive regulatory elements that are active in RIN and GH3 cells. This region is recognized by the pituitary-specific transcription factor Pit-1. It is therefore concluded that Pit-1 represents a major regulator of GH secretion at the genetic level by regulating transcriptional activity not only of the GH gene itself but also of the genes for the receptors that mediate stimulation and inhibition of GH secretion.
ChemInform Abstract: General Approach for the Synthesis of Polyquinenes via the Weiss Reaction (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Finanční analýza vybraného podniku (2008)

V teto bakalařske praci předkladam rozbor hospodařeni konkretniho podniku. Cilem teto prace je pomoci metod financni analýzy ověřit, zda podnik využiva optimalně sve zdroje z pohledu akcionaře a z dlouhodobeho hlediska jaka je likvidni pozice podniku a rizikovost spojena se ziskavanim financnich prostředků. V teoreticke casti teto bakalařske prace uvadim teorii a pojmy, ktere s financni analýzou souvisi a uvadim jednotlive metody financni analýzy. V prakticke casti Vas nejprve seznamim s podnikem, jehož financni analýza je předmětem teto prace. Pomoci různých metod financni analýzy zjistim přislusne ukazatele, pomoci kterých ověřim výse zminěne hypotezy, a zaroveň je porovnam s jejich vývojem v case. Na zavěr teto bakalařske prace provedu vyhodnoceni financni stability a financniho zdravi a navrhuji způsob využiti výsledků financni analýzy ve sledovanem podniku.
Rational Design of Cu-Doped ZnS Nanospheres for Photocatalytic Evolution of H2 with Visible Light (2022)

Photocatalytic reactions to produce hydrogen from water under visible-light irradiation are an important key process for solar energy utilization. Because Cu-doped ZnS undergoes redox reactions upon irradiation with visible light, these materials have been applied to hydrogen production. In this study, Cu-doped ZnS catalysts were prepared by a solvothermal method, and their structures were investigated using scanning electron microscopy, high-resolution transmission electron microscopy, X-ray diffraction, and ultraviolet–visible spectroscopic studies. Cu-doped ZnS consists of nanospherical particles with a diameter of 50 nm. Cu2+ doping in ZnS causes structural distortion of the ZnS. The local structures were analyzed by X-ray absorption fine structure studies. As the amount of Cu added to ZnS increased, the degree of distortion of the ZnS structure also increased, and this degree of distortion reached a maximum when the Cu/Zn ratio was 0.07 (7% Cu doping). Cu-doped ZnS exhibited high activity in the hydrogen production reaction from water using Na2S and Na2SO3 as sacrificial agents under visible-light irradiation (λ > 420 nm), and the highest activity was observed at 7% Cu doping.
Distributed microwave MCM-D circuits for X- and K-band applications (1999)

Future telecommunication applications will shift more and more to the use of higher frequencies. At these high frequencies, lumped passive components can no longer be used and distributed circuits have to be employed instead. This paper introduces such distributed microwave circuits integrated in thin film MCM-D technology. First, a fast and general high frequency analysis and design method for structures in a multilayer configuration is presented. Then, through the examples of broadband couplers and baluns, the design and realization of distributed circuits integrated in MCM-D is demonstrated.
Integrated Vehicle Health Monitoring on a Truck (2022)

There have been few practical of integrated vehicle health monitoring systems for ground vehicles. Once of the challenges of this application is the high dynamics of the engine/transmission and the non-fixed ratio of the transmission, and the drivetrain in general. Further, because of the drivetrain differential, there is no fixed ratio from the input of the differential to the drive wheels. The paper covers the development of a vibration-based vehicle health monitoring system for a truck, and some results of a 1000-mile test run on the system.
Cost effectiveness of sonic drilling (1996)

Sonic drilling (combination of mechanical vibrations and rotary power) is an innovative environmental technology being developed in cooperation with DOE`s Arid-Site Volatile Organic Compounds Integrated Demonstration at Hanford and the Mixed Waste Landfill Integrated Demonstration at Sandia. This report studies the cost effectiveness of sonic drilling compared with cable-tool and mud rotary drilling. Benefit of sonic drilling is its ability to drill in all types of formations without introducing a circulating medium, thus producing little secondary waste at hazardous sites. Progress has been made in addressing the early problems of failures and downtime.
Antimicrobial Protection of the Mouse Testis: Synthesis of Defensins of the Cryptdin Family1 (1997)

We report the synthesis by mouse testicular cells of antibiotic peptides related to the defensins secreted by the Paneth cells of the intestinal epithelium. A Sertoli cell-derived line (15P-1), Sertoli cells in primary cultures, and explanted testicular tissue in culture medium were observed to release protease-sensitive material with a broad-spectrum antibacterial activity. The activity of 15P-1 culture medium was increased 10- to 50-fold in the presence of fractions enriched in round spermatids and of nerve growth factor. Two series of results suggest that this activity may correspond to the release by testicular cells of defensin peptides, and specifically, of peptides of the cryptdin family first identified in the Paneth cells of intestinal crypts. First, a characteristic nucleotide sequence corresponding to the conserved first exon of the mouse cryptdin and cryptdin-related (CRS) genes was evidenced in the RNA of 15P-1 cells and of the testis. Second, immunohistochemical analysis demonstrated the presence of cryptdins of the cryp-1, -2, -3, -6 group in 15P-1 cells, and identified two distinct localizations in the testis. Inside the seminiferous tubule, these cryptdins were found accumulated in Sertoli cells at stages corresponding to the maturation of spermatids. In the interstitial space, Leydig cells also contained immunoreactive cryptdins.
High-Throughput, Kingdom-Wide Prediction and Annotation of Bacterial Non-Coding RNAs (2008)

Candidate loci were identified across all branches of the bacterial evolutionary tree, suggesting a central and ubiquitous role for RNA-mediated regulation among bacterial species. Annotation of candidate loci by SIPHT provides clues into the potential biological function of thousands of previously confirmed and candidate regulatory RNAs and affords new insights into the evolution of bacterial riboregulation.
Noninvasive wall shear stress measurements in human carotid artery using echo particle image velocimetry: Initial clinical studies (2009)

Wall shear stress (WSS) has been shown to be important to endothelial cell function and gene expression. Previous studies have shown that fluid dynamics might be closely related to the initialization of atherosclerotic plaques which preferentially originate in areas of disturbed flow in human vessels, where WSS is low or oscillatory. We recently developed a novel ultrasound-based technique, termed echo particle image velocimetry (echo PIV), by which the multi-component hemodynamic information in human cardiovascular system could be assessed. In this paper, we show that echo PIV was successfully employed to measure hemodynamic information in the right common carotid artery (rCCA) of ten healthy volunteers and that the values show good agreement with phase-contrast magnetic resonance imaging (PC-MRI) measurements with mean absolute differences (mean±SD) of 10.0%±9.8%, 10.1%±8.8% and 17.0%±15.3% for velocity, flow rate and WSS, respectively. In particular, the mean WSS (dynes/cm^2) in rCCA of ten volunteers was found to be 9.2±2.0 by echo PIV, and 8.0±1.4 by PC-MRI, both in agreement with published data. We further showed that calculating WSS by either peak/mean velocity or flow rate together with arterial diameter was invalid for in-vivo measurements due to invalidity of assuming parabolic velocity profile in carotid artery. We found that the peak velocity across radial direction in rCCA was about 1.6 times of the mean velocity, not 2 times as it should be in parabolic distribution. In conclusion, echo PIV demonstrated several advantages over traditional techniques in terms of both temporal and spatial resolution when measuring WSS in human vessels.