gebhart/patrepeval huggingface dataset:
Adverse perinatal outcomes for advanced maternal age: a cross‐sectional study of Brazilian births (2015)

To investigate the risk of adverse perinatal outcomes in women aged ≥ 41 years relatively to those aged 21‐34. Approximately 8.5 million records of singleton births in Brazilian hospitals in the period 2004‐2009 were investigated. Odds ratios were estimated for preterm and post‐term births, for low Apgar scores at 1 minute and at 5 minutes, for asphyxia, for low birth weight, and for macrosomia. For pregnant women ≥ 41, increased risks were identified for preterm births, for post‐term births (except for primiparous women with schooling ≥ 12 years), and for low birth weight. When comparing older vs. younger women, higher educational levels ensure similar risks of low Apgar score at 1 minute (for primiparous mothers and term births), of low Apgar score at 5 minutes (for term births), of macrosomia (for non‐primiparous women), and of asphyxia. As a rule, older mothers are at higher risk of adverse perinatal outcomes, which, however, may be mitigated or eliminated, depending on gestational age, parity, and, especially, on the education level of the pregnant woman. Investigar o risco de resultados perinatais adversos em mulheres ≥ 41 anos relativamente àquelas com idade 21‐34. Cerca de 8,5 milhões de registros de nascimentos únicos em hospitais brasileiros no período 2004‐2009 foram investigados. Odds ratios foram estimados para nascimentos prematuros e pós‐termo, baixos índices de Apgar no 1° e 5° minutos, asfixia, baixo peso ao nascer e macrossomia. Para as mulheres grávidas ≥ 41, aumento de riscos foram identificados para nascimentos prematuros, partos pós‐termo (com exceção de primíparas com escolaridade ≥ 12 anos) e baixo peso ao nascer. Relativamente a mulheres mais velhas vs. mais jovens, maiores níveis de escolaridade garantem riscos semelhantes de baixo índice de Apgar no 1° minuto (para primíparas e nascimentos a termo), de baixo índice de Apgar no 5° minuto (para nascimentos a termo), de macrossomia (para não primíparas) e de asfixia. Em geral, mães mais velhas estão sob maiores riscos de desfechos perinatais adversos, mas esses são minimizados ou eliminados a depender da idade gestacional, da paridade e, em especial, da escolaridade da gestante.
Adversarial Framing for Image and Video Classification (2019)

Neural networks are prone to adversarial attacks. In general, such attacks deteriorate the quality of the input by either slightly modifying most of its pixels, or by occluding it with a patch. In this paper, we propose a method that keeps the image unchanged and only adds an adversarial framing on the border of the image. We show empirically that our method is able to successfully attack state-of-theart methods on both image and video classification problems. Notably, the proposed method results in a universal attack which is very fast at test time. Source code can be found at github.com/zajaczajac/adv_framing.
DEVELOPMENT OF A NEW PREDICTION METHOD OF ROCK MASS STABILITY BASED ON THE RESULTS OF THE BACK ANALYSIS DURING EXCAVATION (2002)

本論文は, 地下空洞のように多段ステップ掘削が行われる工事において, アーチ部等の掘削途中段階で計測された変位に逆解析を適用して岩盤安定性を定量的に評価するとともに, それを利用して岩盤の応力-ひずみ関係の非線形パラメーターを適切に推定し, その後の掘削段階における岩盤安定性をその非線形性も考慮して推定する方法を開発したものである. この方法は, Duncan-Chang の非線形弾性構成則が岩盤に適用できるものと仮定して, 著者らが先に開発した非均質挙動を考慮可能な逆解析の適用結果から, この非線形パラメーターを適切に推定し, その後の掘削解析では Duncan-Chang の非線形弾性解析を行うものである. この方法を実際の地下空洞掘削に適用した結果, 従来の予測解析法よりも早めの掘削段階で岩盤が不安定化する可能性のある領域を適切に予測できることが判明した.
The Renal Dopaminergic System, Hypertension, and Salt Sensitivity (2007)

The kidney is the primary organ responsible for the long-term control of blood pressure by regulating sodium and chloride transport. Various renal autocrine/paracrine and endocrine mechanisms have evolved to increase or decrease sodium reabsorption in different segments of the nephron (1,2).
Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product. (1998)

The p16/MTS1 gene is altered by deletion, mutation, or hypermethylation in a wide variety of human cancers. As a result of deficient p16 protein, these cancers lack a critical mechanism for halting G1/S cell cycle progression. In the current study, 59 cases of nasopharyngeal carcinoma were evaluated for expression of the p16 tumor suppressor protein by immunohistochemical analysis of paraffin-embedded tissue. There was no detectable p16 in 38/59 cases (64%), which implies a very high rate of p16 inactivation in this type of cancer. On the other hand, the retinoblastoma gene product, which also regulates the G1 to S phase transition of the cell cycle, was consistently expressed in nasopharyngeal carcinomas by immunohistochemical analysis. These results implicate p16 inactivation but not Rb alteration in the stepwise progression of nasopharyngeal carcinogenesis.
Interfacing enzymes with silicon nanocrystals through the thiol–ene reaction (2018)

This study reports the preparation of functional bioinorganic hybrids, through application of the thiol-ene reaction, that exhibit catalytic activity and photoluminescent properties from enzymes and freestanding silicon nanocrystals. Thermal hydrosilylation of 1,7-octadiene and alkene-terminated poly(ethylene oxide)methyl ether with hydride-terminated silicon nanocrystals afforded nanocrystals functionalized with alkene residues and poly(ethylene oxide) moieties. These silicon nanocrystals were conjugated with representative enzymes through the photochemical thiol-ene reaction to afford bioinorganic hybrids that are dispersible and photostable in buffer, and that exhibit photoluminescence (λ<sub>max</sub> = 630 nm) and catalytic activity. They were characterized using Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), dynamic light scattering analysis (DLS), absorption spectroscopy, steady-state and time-resolved photoluminescence spectroscopy, and pertinent enzyme activity assays. The general derivatization approach presented for interfacing enzymes with biocompatible silicon nanocrystals has far reaching implications for many applications ranging from sensors to therapeutic agents. The bioinorganic hybrids presented herein have potential applications in the chemical detection of nitrophenyl esters and urea. They can also be employed in enzyme-based theranostics as they combine long-lived silicon nanocrystal photoluminescence with substrate-specific enzymatic activity.
ChemInform Abstract: NUCLEOSIDES. 133. SYNTHESIS OF 5‐ALKENYL‐1‐(2‐DEOXY‐2‐FLUORO‐β‐D‐ARABINOFURANOSYL)CYTOSINES AND RELATED PYRIMIDINE NUCLEOSIDES AS POTENTIAL ANTIVIRAL AGENTS (1985)

Abstract Entsprechend dem Formelschema werden die Pyrimidin‐Nucleoside (III)‐(VI) und (IX) synthetisiert und auf antileukämische und antivirale Wirkung getestet.
Dynamically Repairing and Replacing Neural Networks: Using Hybrid Computational and Biological Tools (2012)

The debilitating effects of injury to the nervous system can have a profound effect on daily life activities of the injured person. In this article, we present a project overview in which we are utilizing computational and biological principles, along with simulation and experimentation, to create a realistic computational model of natural and injured sensorimotor control systems. Through the development of hybrid in silico/biological coadaptive symbiotic systems, the goal is to create new technologies that yield transformative neuroprosthetic rehabilitative solutions and a new test bed for the development of integrative medical devices for the repair and enhancement of biological systems.
Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity (2016)

Recombinant immunotoxins (RITs) are genetically engineered proteins being developed to treat cancer. They are composed of an Fv that targets a cancer antigen and a portion of a protein toxin. Their clinical success is limited by their immunogenicity. Our goal is to produce a new RIT that targets mesothelin and is non-immunogenic by combining mutations that decrease B- and T-cell epitopes. Starting with an immunotoxin that has B-cell epitopes suppressed, we added mutations step-wise that suppress T-cell epitopes. The final protein (LMB-T14) has greatly reduced antigenicity as assessed by binding to human anti-sera and a greatly decreased ability to activate helper T-cells evaluated in a T-cell activation assay. It is very cytotoxic to mesothelioma cells from patients, and to cancer cell lines. LMB-T14 produces complete remissions of a mesothelin expressing cancer (A431/H9) xenograft. The approach used here can be used to de-immunize other therapeutic foreign proteins.
A Semiconductor-Based 10-GHz Optical Comb Source With Sub 3-fs Shot-Noise-Limited Timing Jitter and $\sim$500-Hz Comb Linewidth (2010)

In this work, a 10.287-GHz semiconductor-based harmonically mode-locked laser with 1000 finesse intracavity etalon is demonstrated. The timing jitter integrated from 1 Hz to 100 MHz (Nyquist) is 3 fs (14 fs). The optical linewidth is ~500 Hz and the optical frequency stability is <150 kHz over 30 s.
Comparative evaluation of three-phase high power factor AC-DC converter concepts for application in future more electric aircrafts (2004)

A passive 12-pulse rectifier system, a two-level, and a three-level active three-phase PWM rectifier system are analyzed for supplying the DC voltage link of a 5 kW variable speed hydraulic pump drive of an electro-hydrostatic actuator to be employed in future more electric aircrafts. Weight, volume and efficiency of the concepts are compared for an input phase voltage range of 98 V to 132 V and an input frequency range of 400 Hz to 800 Hz. The 12-pulse system shows advantages concerning volume, efficiency and complexity but is characterized by a high system weight. Accordingly, the three-level PWM rectifier is identified as most advantageous solution. Finally, a novel extension of the 12-pulse rectifier system by turn-off power semiconductors is proposed which allows a control of the output voltage and therefore eliminates the dependency on the mains and load condition which constitutes a main drawback of the passive concept.
Hydralazine and Organic Nitrates Restore Impaired Excitation-Contraction Coupling by Reducing Calcium Leak Associated with Nitroso-Redox Imbalance* (2013)

Although the combined use of hydralazine and isosorbide dinitrate confers important clinical benefits in patients with heart failure, the underlying mechanism of action is still controversial. We used two models of nitroso-redox imbalance, neuronal NO synthase-deficient (NOS1(-/-)) mice and spontaneously hypertensive heart failure rats, to test the hypothesis that hydralazine (HYD) alone or in combination with nitroglycerin (NTG) or isosorbide dinitrate restores Ca(2+) cycling and contractile performance and controls superoxide production in isolated cardiomyocytes. The response to increased pacing frequency was depressed in NOS1(-/-) compared with wild type myocytes. Both sarcomere length shortening and intracellular Ca(2+) transient (Δ[Ca(2+)]i) responses in NOS1(-/-) cardiomyocytes were augmented by HYD in a dose-dependent manner. NTG alone did not affect myocyte shortening but reduced Δ[Ca(2+)]i across the range of pacing frequencies and increased myofilament Ca(2+) sensitivity thereby enhancing contractile efficiency. Similar results were seen in failing myocytes from the heart failure rat model. HYD alone or in combination with NTG reduced sarcoplasmic reticulum (SR) leak, improved SR Ca(2+) reuptake, and restored SR Ca(2+) content. HYD and NTG at low concentrations (1 μm), scavenged superoxide in isolated cardiomyocytes, whereas in cardiac homogenates, NTG inhibited xanthine oxidoreductase activity and scavenged NADPH oxidase-dependent superoxide more efficiently than HYD. Together, these results revealed that by reducing SR Ca(2+) leak, HYD improves Ca(2+) cycling and contractility impaired by nitroso-redox imbalance, and NTG enhanced contractile efficiency, restoring cardiac excitation-contraction coupling.
IF-over-Fiber Technology Aiming at Efficient Bandwidth Utilization and Perfect Centralized Control for Next-Generation Mobile Fronthaul Links in C-RAN Architectures (2017)

The intermediate frequency-over-fiber (IFoF) technology has attracted attention as an alternative transmission scheme to the functional split for the next-generation mobile fronthaul links due to its high spectral efficiency and perfect centralized control ability. In this paper, we discuss and clarify network architectures suited for IFoF, based on its advantages over the functional split. One of the major problems for IFoF transmission is dispersion-induced RF power fading, which limits capacity and transmission distance. We introduce our previous work, in which high-capacity and long-distance IFoF transmission was demonstrated by utilizing a parallel intensity/phase modulators (IM/PM) transmitter which can effectively avoid the fading. The IFoF technology with the proposed scheme is well suited for the long-distance mobile fronthaul links for the 5th generation (5G) mobile system and beyond.
Distinct Sustainable Carbon Nanodots Enable Free Radical Photopolymerization, Photo‐ATRP and Photo‐CuAAC Chemistry (2021)

Carbon nanodots (CDs) originating from different biomass result in different activities to sensitize photo-ATRP and photo-CuAAC reaction protocols with visible light. Free radical polymerization of tri(propylene glycol)diacrylate also exhibited a good efficiency using CDs in combination with an iodonium salt employing LEDs emitting either at 405 nm, 525 nm or 660 nm. Photo-ATRP experiments confirmed controlled polymerization conditions using Cu<sup>II</sup> at the ppm scale resulting in dispersities between 1.06 to 1.10. Chain end fidelity was successfully provided by chain extension and block copolymerization additionally approving the living feature of polymerization using a CD synthesized from lac dye comprising olefinic moieties in the originating biomass. By global analysis, time resolved fluorescence measurements indicated the appearance of several emitting species contributing to the reactivity of the excited states. Different cytotoxic response appeared following the answer of MCF-10A cells in a flow cytometry assay; that is 400 μg mL<sup>-1</sup> . Thus, cell viability was greater 80 % in the case of CD-2-CD-5 while that of CD-1 was close to 70 %.
Efficient photoinduced charge separation in layered zirconium viologen phosphonate compounds. [Erratum to document cited in CA120(2):18913f] (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEfficient photoinduced charge separation in layered zirconium viologen phosphonate compounds. [Erratum to document cited in CA120(2):18913f]Loria A. Vermeulen, Jonathan L. Snover, Linda S. Sapochak, and Mark E. ThompsonCite this: J. Am. Chem. Soc. 1994, 116, 7, 3175Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/ja00086a078https://doi.org/10.1021/ja00086a078research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Porous Tantalum Metaphyseal Cones for Severe Tibial Bone Loss in Revision Knee Arthroplasty (2015)

Porous tantalum tibial cones offer a promising management option for severe tibial bone loss. At the intermediate-term follow-up (five to nine years), porous tantalum tibial cones had durable clinical results and radiographic fixation. The biologic ingrowth of these implants offers the potential for successful long-term structural support in complex knee reconstruction.
A Compact-Finite-Difference-Based Numerical Framework for Adaptive-Grid-Refinement Simulations of Vortex-Dominated Flows (2020)

This paper presents an adaptive mesh refinement method for DNS simulating turbulent flows, with focus on simulating vortex dynamics problems. The compressible Navier-Stokes equations are solved on the multi-block computational domain with compact-finite-difference scheme. Staggered arrangement for variables are used which has shown superior advantage in robustness and accuracy for turbulent flow simulations. With the combination of high-order interpolation and high-order compact difference operator, an overall 4th-order accuracy in space can be achieved. The refinement test function is given by a sensor based on the gradient of vorticity. Test cases on vortex dynamics problems have shown that this sensor is capable of capturing and refining the location where the strain-rate is high and turbulent breakdown occurs. Future work includes DNS simulations on a topologically complicated knotted vortex reconnection problems at high Reynolds number.
Velocity regulation limits in a precision two-dimensional magnetic levitator (1999)

High-precision scanning stages need very smooth velocity, and characterization of error motions is an important task in precision positioning applications. A magnetically levitated stage is a promising solution to higher resolution systems, especially in vacuum, where other types of hearings are problematic.
Minimum tracking &amp; focusing trajectory control based on two-dimensional equivalent PTC for optical disk (2014)

Pickup systems for optical disks operate in the horizontal and vertical directions for tracking and focusing, respectively. Control systems for optical disks consist of focusing control and tracking control for each operation direction. Therefore, this paper proposes a new minimum tracking & focusing trajectory control based on two-dimensional feedforward control system. Two-dimensional feedforward control system makes the error vector combined focusing error and tracking error. The error vector is the input variable into the feedforward compensator on the basis of a zero phase error tracking control. Because, it is difficult to perform high-speed sampling in a conventional two-dimensional control system, the proposed two-dimensional feedforward compensator can perform high-speed sampling, which is based on an equivalent-perfect tracking control. The experimental results show the effectiveness of the proposed control system.
Stability of person-specific blood-based infrared molecular fingerprints opens up prospects for health monitoring (2021)

Health state transitions are reflected in characteristic changes in the molecular composition of biofluids. Detecting these changes in parallel, across a broad spectrum of molecular species, could contribute to the detection of abnormal physiologies. Fingerprinting of biofluids by infrared vibrational spectroscopy offers that capacity. Whether its potential for health monitoring can indeed be exploited critically depends on how stable infrared molecular fingerprints (IMFs) of individuals prove to be over time. Here we report a proof-of-concept study that addresses this question. Using Fourier-transform infrared spectroscopy, we have fingerprinted blood serum and plasma samples from 31 healthy, non-symptomatic individuals, who were sampled up to 13 times over a period of 7 weeks and again after 6 months. The measurements were performed directly on liquid serum and plasma samples, yielding a time- and cost-effective workflow and a high degree of reproducibility. The resulting IMFs were found to be highly stable over clinically relevant time scales. Single measurements yielded a multiplicity of person-specific spectral markers, allowing individual molecular phenotypes to be detected and followed over time. This previously unknown temporal stability of individual biochemical fingerprints forms the basis for future applications of blood-based infrared spectral fingerprinting as a multiomics-based mode of health monitoring.
Alignment of cortical vessels viewed through the surgical microscope with preoperative imaging to compensate for brain shift (2020)

Brain shift is a non-rigid deformation of brain tissue that is affected by loss of cerebrospinal fluid, tissue manipulation and gravity among other phenomena. This deformation can negatively influence the outcome of a surgical procedure since surgical planning based on pre-operative image becomes less valid. We present a novel method to compensate for brain shift that maps preoperative image data to the deformed brain during intra-operative neurosurgical procedures and thus increases the likelihood of achieving a gross total resection while decreasing the risk to healthy tissue surrounding the tumor. Through a 3D/2D non-rigid registration process, a 3D articulated model derived from pre-operative imaging is aligned onto 2D images of the vessels viewed through the surgical miscroscopic intra-operatively. The articulated 3D vessels constrain a volumetric biomechanical model of the brain to propagate cortical vessel deformation to the parenchyma and in turn to the tumor. The 3D/2D non-rigid registration is performed using an energy minimization approach that satisfies both projective and physical constraints. Our method is evaluated on real and synthetic data of human brain showing both quantitative and qualitative results and exhibiting its particular suitability for real-time surgical guidance.
Aging and Interstitial Lung Diseases: Unraveling an Old Forgotten Player in the Pathogenesis of Lung Fibrosis (2010)

Aging is a natural process characterized by a progressive functional impairment and reduced capacity to respond adaptively to environmental stimuli. Aging is associated with increased susceptibility to a variety of chronic diseases, including type 2 diabetes mellitus, cancer, and neurological diseases. Lung pathologies are not the exception, and the prevalence of several interstitial lung diseases (ILDs), primarily idiopathic pulmonary fibrosis, has been found to increase considerably with age. Although our understanding of the biology of aging has advanced remarkably in the last 2 decades, the molecular mechanisms linking aging to ILD remain unclear. Immunosenescence, oxidative stress, abnormal shortening of telomeres, apoptosis, and epigenetic changes affecting gene expression have been proposed to contribute to the aging process, and aging-associated diseases. Here, we review the emerging concepts highlighting the putative aging-associated abnormalities involved in some human ILDs.
ChemInform Abstract: Synthesis and Reactivity of Two Monomeric Tungsten(IV) Phenoxide Complexes. (1988)

Abstract The monomeric W(IV) phenoxide complexes (III) are synthesized according to the scheme.
Three-photon absorption spectra of zinc blende semiconductors: theory and experiment: erratum (2020)

We provide a correction to the spectral dependence of the three-photon absorption in zinc-blende semiconductors using Kane’s 4-band model in Opt. Lett. 33 , 2626 ( 2008 ). OPLEDP 0146-9592 10.1364/OL.33.002626