gebhart/patrepeval huggingface dataset:
Effects of Acute and Chronic Hyperglycemia on Morphine-Induced Inhibition of Gastrointestinal Transit in Mice (1988)

Using the charcoal meal test, the effects of morphine (3, 5 and 7 mg/kg) on gastrointestinal transit was assessed in normoglycemic as well as in acute and chronic hyperglycemic mice. Acute hyperglycemia was induced by intraperitoneal injection of glucose (5.04 g/kg), while chronic hyperglycemia was induced by streptozotocin injection (200 mg/kg i.p., 7-8 days before). Acute hyperglycemia augmented the inhibitory effect of morphine on gut transit, however, chronic hyperglycemia failed to modify the effects of morphine. The results indicate that hyperglycemia per se may not be the primary mechanism for the altered sensitivity to morphine in experimental models of diabetes.
Characterization and applicability of the natural Iraqi bentonite clay for toxic cationic dye removal: Adsorption kinetic and isotherm study (2023)

This research targets to adsorb the organic dye (methylene blue, MB) from aqueous media using natural Iraqi bentonite clay (NIBC). Several analytical methods (e.g., XRD, FTIR, SEM-EDX, XRF, pHpzc, and BET) analysis were conducted to inspect the physicochemical characteristics of the NIBC. Adsorption key variables, including dosage of adsorbent (0.02–0.1 g), pH (2–10), and initial concentrations (10–150 mg/L) were inspected for determining their impacts on MB dye removal. The Redlich-Peterson isotherm demonstrated the best account for the equilibrium adsorption of MB. The NIBC's highest adsorption capacity (qmax) for MB was 256 mg/g. The kinetics of the adsorption of MB by NIBC matched the pseudo-second-order model. This study demonstrates that the NIBC could be utilized to successfully remove MB from aqueous environments.
Pre‐emphasis enabled 50 Gbit/s transmission over 1000 m SMF using a 1060 nm single‐mode VCSEL (2018)

A single‐mode 1060 nm vertical‐cavity surface‐emitting laser (VCSEL) and single‐mode fibre (SMF) based link with two‐tap active pre‐emphasis enabling error‐free transmission of 50 Gbit/s NRZ‐OOK over 1000 m is presented.
Modeling, identification and control of a Boat Parking Assistance system (2013)

In this paper, the problem of designing a Boat Parking Assistance (BPA) system for a small-scale vessel is addressed. A control-oriented model is derived from the physics underlying the system and gray-box identification is carried out by designing suitable experiments. A 3 DOF cascade control scheme is then implemented to achieve semi-automatic parking and station-keeping. The latter is also shown to be a solid groundwork for future research on fully automatic maneuvering. The proposed strategy is finally tested on stationkeeping and parking of a real vessel.
Method and apparatus for secondary laser pumping by electron beam excitation (2023)

An electron beam of energy typically 100 keV excites a fluorescer gas which emits ultraviolet radiation. This radiation excites and drives an adjacent laser gas by optical pumping or photolytic dissociation to produce high efficiency pulses. The invention described herein was made in the course of, or under, United States Energy Research and Development Administration Contract No. W-7405-Eng-48 with the University of California.
Online Graph-Guided Inference Using Ensemble Gaussian Processes of Egonet Features (2021)

Graph-guided semi-supervised learning (SSL) and inference has emerged as an attractive research field thanks to its documented impact in a gamut of application domains, including transportation and power networks, biological, social, environmental, and financial ones. Distinct from SSL approaches that yield point estimates of the variables to be inferred, the present work puts forth a Bayesian interval learning framework that utilizes Gaussian processes (GPs) to allow for uncertainty quantification – a key component in safety-critical applications. An ensemble (E) of GPs is employed to offer an expressive model of the learning function that is updated incrementally as nodal observations become available – what caters also for delay-sensitive settings. For the first time in graph-guided SSL and inference, egonet features per node are utilized as input to the EGP learning function to account for higher order interactions than the one-hop connectivity of each node. Further enhancing these attributes through random features that encrypt sensitive information per node offers scalability and privacy for the EGP-based learning approach. Numerical tests on real and synthetic datasets corroborate the effectiveness of the novel method.
Simultaneous Expression of Different Variant-Specific Surface Proteins in Single Giardia lamblia Trophozoites during Encystation (2002)

A novel variant-specific surface protein (VSP) from Giardia was identified using the monoclonal antibody 9B10, raised against purified cyst walls. VSP9B10B is preferentially induced during encystation and expressed simultaneously with other VSPs on the surface of encysting trophozoites. These results support the hypothesis that encystation and antigenic variation are processes that are mechanistically related.
A Wound Caused by a Small Alkaline Cell (Button Battery) Under a Plaster Cast: Report of a Case (2009)

This is a case report of only the second known instance of an alkaline cell (button battery) causing a wound under a plaster cast.
Physics of Hot Crossflow Ingestion in Film Cooling (1999)

Computational fluid dynamics (CFD) is used to isolate the flow physics responsible for hot crossflow ingestion, a phenomenon that can cause failure of a film cooled gas turbine component. In the gas turbine industry, new compound-angle shaped hole (CASH) geometries are currently being developed to decrease the heat transfer coefficient and increase the adiabatic effectiveness on film cooled surfaces. These new CASH geometries can have unexpected flow patterns that result in hot crossflow ingestion at the film hole. This investigation examines a 15 deg forward-diffused film hole injected streamwise at 35 deg with a compound angle of 60 deg (FDIFF60) and with a length-to-diameter ratio (L/D) of 4.0. Qualitative and quantitative aspects of computed results agreed well with measurements, thus lending credibility to predictions. The FDIFF60 configuration is a good representative of a typical CASH geometry, and produces flow mechanisms that are characteristic of CASH film cooling. FDIFF60 has been shown to have impressive downstream film cooling performance, while simultaneously having undesirable ingestion at the film hole. In addition to identifying the physical mechanisms driving ingestion, this paper documents the effects on ingestion of the blowing ratio, the density ratio, and the film hole Reynolds number over realistic gas turbine ranges of 0.5 to 1.88, 1.6 to 2.0, and 17,350 to 70,000, respectively. The results of this study show that hot crossflow ingestion is caused by a combination of coolant blockage at the film hole exit plane and of crossflow boundary layer vorticity that has been re-oriented streamwise by the presence of jetting coolant. Ingestion results when this re-oriented vorticity passes over the blocked region of the film hole. The density ratio and the film hole Reynolds number do not have a significant effect on ingestion over the ranges studied, but the blowing ratio has a surprising nonlinear effect. Another important result of this study is that the blockage of coolant hampers convection and allows diffusion to transfer heat into the film hole even when ingestion is not present. This produces both an undesirable temperature gradient and high temperature level on the film hole wall itself. Lessons learned about the physics of ingestion are generalized to arbitrary CASH configurations. The systematic computational methodology currently used has been previously documented and has become a standard for ensuring accurate results. The methodology includes exact modeling of flow physics, proper modeling of the geometry including the crossflow, plenum, and film hole regions, a high quality mesh for grid independent results, second order discretization, and the two-equation k–ε turbulence model with generalized wall functions. The steady, Reynolds-averaged Navier–Stokes equations are solved using a fully elliptic and fully implicit pressure-correction solver with multiblock unstructured and adaptive grid capability and with multigrid convergence acceleration.
A systematic experimental investigation of thermal degradation mechanisms in lidded flip-chip packages: Effects of thermal aging and cyclic loading (2017)

This research effort is geared towards establishing a robust virtual-qualification methodology for thermal performance of flip-chip packages. In the experimental analysis presented here, test vehicles were designed and tested for degradation in the module-level thermal interface material under high temperature storage (at 100C, 125C and 150C) exposure and deep thermal cycling (-40C/+125C) conditions. The experiments conducted in this study will encompass a wide range of thermo-mechanical conditions that not only explore known JEDEC variables but also provide unique insights into understanding the effects of indirect thermal degradation drivers such as package assembly loads and chipjunction temperature variations during thermal power inputs during readouts.
Fluorinated NAD as an affinity surfactant (2002)

Nicatinamide adenine dinucleotide (NAD) with an attached perfluoropolyether tail acts as an affinity surfactant in the extraction of the enzyme horse liver alcohol dehydrogenase (HLADH) from an aqueous medium into a fluorous solvent.
Analysis and ray tracing modelling of co- and cross-polarization radio propagation in urban environment (2007)

The co- and cross-polarization behaviour of the urban propagation channel has been studied through both MIMO measurements and ray tracing (RT) simulation. A ray tracing model including diffuse scattering has been adopted, allowing the role of diffuse scattering to be highlighted through comparison between measurement and simulation. The high degree of cross-polarization power transfer observed in both measurement and simulation seems to be partly due to multipath propagation (and to diffuse scattering in particular), and partly due to the polarization behaviour of the antennas.
756. Distinct Classes of Proteasome-Modulating Agents Cooperatively Augment Recombinant Adeno-Associated Virus Type 2 and Type 5-Mediated Transduction from the Apical Surface of Human Airway Epithelia (2004)

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Tripeptidyl aldehyde proteasome inhibitors have been shown to effectively increase viral capsid ubiquitination and transduction of recombinant adeno-associated virus (rAAV) type 2 and 5 serotypes. In the present study, we have characterized a second class of proteasome-modulating agents (anthracycline derivatives) for their ability to induce rAAV transduction. The anthracycline derivatives doxorubicin and aclarubicin were chosen for analysis because they have been shown to interact with the proteasome through a mechanism distinct from that of tripeptidyl aldehydes. Our studies demonstrated that doxorubicin and aclarubicin also significantly augmented rAAV transduction in airway cell lines and polarized human airway epithelia, human bronchial xenografts, and mice lungs. Both tripeptidyl aldehyde and anthracycline proteasome-modulating agents similarly augmented nuclear accumulation of rAAV in A549 and IB3 airway cell lines but did not directly enhance the efficiency of second- strand synthesis for AAV genome conversion. However, these two cell types demonstrated cell specificity in terms of the ability of LLnL or doxorubicin to augment rAAV transduction. Interestingly, the combined administration of LLnL and doxorubicin resulted in substantially increased transduction (>2000 fold) following apical infection of human polarized epithelia with either rAAV-2 or rAAV-5. In summary, the cell-type specificity of LLnL and doxorubicin to induce rAAV transduction, together with the ability of these compounds to synergistically enhance rAAV transduction in polarized airway epithelial induction, suggest that these two classes of compounds likely modulate different proteasome functions that affect rAAV transduction. Findings from this study provide new insights into how modulation of the proteasome function can be used to augment rAAV transduction in airway epithelia for gene therapy of cystic fibrosis.
Imaging Cells using Intracellular Bimodal Optical and MR contrast agents (2006)

Advances in Magnetic Resonance Imaging (MRI) have revolutionized the way in which cellular and physiological processes are being investigated. The specificity and sensitivity of MR imaging can be further enhanced by the introduction of contrast agents (CA). Most of the available CA like Gd-DTPA, Gd-DOTA are non-specific and restricted to the extracellular space. A new generation of intracellular CA can be developed for labeling cells specifically by coupling with special peptides known as cell penetrating peptides (CPP) that convey cargo molecules attached to it across the cell membrane. Amongst the large variety of CPP available, Tat49-57 peptide (derived from HIV-1 Tat protein) is the most intensively studied and has high delivery ability for vast variety of cargos. It has been reported that better internalization is observed with retro-inverso isomer of Tat using d-form of the peptide [1] and also by introduction of modifications in sequence like replacement of glutamine (q) with ornithine (Orn, o) [2]. We present here synthesis of bimodal (magnetic and fluorescent) MR CA based on Gd-DTPA conjugated to a fluorescent dye fluorescein isothiocyanate (FITC) and CPP (Figure 1). The CPP fragments were synthesized on solid phase by Fmoc (9-fluorenylmethoxycarbonyl) mediated scheme. One lysine residue was coupled to the CPP fragment as a linker for DTPA dianhydride (via α-amino group) and FITC (via ε-amino group). The peptide conjugates were then cleaved from solid phase. After purification by reversed-phase HPLC, the conjugates were chelated with Gd3+. The products were again purified by HPLC and characterized by ESI-MS. The obtained bimodal CA were tested on cells for their internalization efficiency and cytotoxicity using fluorescence and MR imaging. Orn-d-Tat CA exhibited much better internalization compared to d-Tat CA but was also accompanied with increased toxicity. Also a difference in internalization mechanism was observed with orn-d-Tat CA. To conclude, a balance needs to be maintained between the internalization efficiency and toxicity in order to obtain a proficient intracellular MR CA that can be used for cellular tracking.
P1‐144: Assessment of structural differences in normal aging and Alzheimer's disease: Quantitative and qualitative differences using subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) (2009)

It has been suggested that the changes encountered in AD are largely an amplification of lesser but similar changes constituting “cognitive aging”. New automated techniques and large sample sizes allow for a more precise examination of between group morphological differences. We propose to examine whether AD and “normal aging” are only quantitatively different with respect to their cortical thickness and white and gray matter density “signature”, or differ in fundamental ways between the two groups. T1 volumes (196 elderly controls, 160 age-matched AD subjects; age range 57-91, mean=76) were acquired from the ADNI database, and processed at the Montreal Neurological Institute by a fully automated analysis pipeline. The resultant tissue classification volumes were used in the voxel-based morphometry (VBM) analysis; cortical surfaces were used to extract cortical thickness values. Statistical analysis consisted regressing cortical thickness or tissue density, onto age and diagnostic group. Regression of cortical thickness onto diagnostic group, demonstrated significant widespread cortical thinning in the AD group in all lobes, with relative sparing of sensory and motor areas. The largest absolute losses were seen bilaterally in middle temporal gyri, insulae, and along with the left supramarginal gyrus (> ¼ mm loss), and in the medial temporal cortex bilaterally (> ½ mm loss). Normal elderly subjects showed additional age-related thinning in primary sensory and motor areas, including primary visual and auditory cortices. The VBM analyses found that differences within the medial temporal structures were primarily quantitative in nature, with both groups showing significant bilateral hippocampal atrophy, in addition to a significant white matter loss in three regions: periventricular, callosal, and adjacent to the hippocampus. AD-related morphological changes are both quantitatively and qualitatively different from normal aging. Tissue loss within frontal and temporal association cortex, in addition to that observed within and adjacent to the hippocampus, reflects an exacerbation of normal age-related changes. Conversely, tissue loss within the insulae is only seen in AD, whereas significant thinning within the primary sensory and motor cortices is reflective of normal aging.
Ketopiperazines: Conformationally Constrained Peptidomimetic of Arginine Amides. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
On full-waveform modeling and inversion of fiber-optic VSP data (2017)

Fiber-optic-based distributed acoustic/vibration sensing technology opens up new prospects for vertical seismic profiling (VSP). Basic VSP processing algorithms have been successfully adapted to the new measurements. We aim to extract more from the acquired data by investigating the feasibility of full-waveform inversion. We report on our current progress, which comprises conventional data inversion (providing reference result), synthetic modeling of distributed vibration sensing (DVS) waveforms and a synthetic inversion test for a low noise case. Presentation Date: Tuesday, September 26, 2017 Start Time: 3:55 PM Location: 371A Presentation Type: ORAL
Comité Scientifique Avis en réponse à la saisine HCB - dossier NL-2005-281. Paris, le 17 mars 2016 (2016)

Le Haut Conseil des biotechnologies (HCB) a été saisi le 15 juillet 2015 par les autorités compétentes françaises (le ministère de l’Agriculture, de l’Agroalimentaire et de la Forêt) d’une demande d’avis relatif au dossier EFSA-GMO-NL-2005-28 de demande d’autorisation de mise sur le marché du maïs génétiquement modifié 1507 x 59122 à des fins de culture, importation, transformation et alimentation humaine et animale. Ce dossier a été conjointement déposé par les sociétés Mycogen Seeds c/o Dow AgroSciences LLC et Pioneer Hi-Bred International, Inc. auprès des autorités compétentes néerlandaises sur le fondement du règlement (CE) n° 1829/2003. L’objectif de cet avis est d’éclairer les autorités compétentes françaises en perspective d’un vote des Etats membres sur un projet de décision d’autorisation de mise sur le marché de ce maïs pour les usages spécifiés dans l’Union européenne. Le Comité scientifique (CS)2 du HCB a examiné le dossier en séance du 26 novembre 2015 sous la présidence de Jean-Christophe Pagès. Le présent avis a été adopté par voie électronique, transmis aux autorités compétentes et publié sur le site du HCB le 17 mars 2016.
Technologie der Extrusion (2017)

You have accessTechnologie der ExtrusionDec 2017Technologie der ExtrusionHelmut Greif, Andreas Limper, Gordon FattmannHelmut Greif, Andreas Limper, Gordon Fattmannhttps://doi.org/10.3139/9783446436947.fmSectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn next chapter FiguresReferencesRelatedDetails 2017Pages: I-XVIPrint ISBN: 978-3-446-43693-0eISBN: 978-3-446-43694-7 Copyright & Permissions© 2017 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Synthesis of polypropylene with improved MgCl2‐supported Ziegler‐Natta catalysts, including silane compounds as external bases (1989)

Abstract The new catalytic system comprising a diester as an internal Lewis base and a silane (triethoxyphenylsilane) as an external Lewis base presents important differences to the classical third generation catalyst with two esters in the system, i. e. a high isotacticity is obtained with a low ratio Al/Lewis base, the stereospecificity is stable with temperature and time, the sensitivity to hydrogen concerning the average molecular weight is high and the activity, which remains low without hydrogen, is greatly enhanced by the transfer agent. The selectivity of the system is controlled in a complex manner by the concentration and ratio of the cocatalytic system.
Analysis of the semileptonic decay D0→K¯0π−μ+ν (2004)

Using data collected by the fixed target Fermilab experiment FOCUS, we present several first measurements for the semileptonic decay D0→K¯0π−μ+ν. Using a model that includes a K¯0π− s-wave component, we measure the form factor ratios to be rv=1.71±0.68±0.34 and r2=0.91±0.37±0.10 and the s-wave amplitude to be A=0.35±0.22±0.05GeV−1. Finally, we measure the vector semileptonic branching ratio Γ(D0→K*(892)−μ+ν)Γ(D0→K¯0π−π+)=0.337±0.034±0.013.
Breath figure–derived porous semiconducting films for organic electronics (2020)

Porous semiconductor film morphologies facilitate fluid diffusion and mass transport into the charge-carrying layers of diverse electronic devices. Here, we report the nature-inspired fabrication of several porous organic semiconductor-insulator blend films [semiconductor: P3HT (p-type polymer), C8BTBT (p-type small-molecule), and N2200 (n-type polymer); insulator: PS] by a breath figure patterning method and their broad and general applicability in organic thin-film transistors (OTFTs), gas sensors, organic electrochemical transistors (OECTs), and chemically doped conducting films. Detailed morphological analysis of these films demonstrates formation of textured layers with uniform nanopores reaching the bottom substrate with an unchanged solid-state packing structure. Device data gathered with both porous and dense control semiconductor films demonstrate that the former films are efficient TFT semiconductors but with added advantage of enhanced sensitivity to gases (e.g., 48.2%/ppm for NO<sub>2</sub> using P3HT/PS), faster switching speeds (4.7 s for P3HT/PS OECTs), and more efficient molecular doping (conductivity, 0.13 S/m for N2200/PS).
Neonatal Vaccination and Maternal Immunization (2020)

This concise book captures the essence of current and future shifts in vaccine development research that will likely transform our understanding of methods to stimulate specific and protective immune responses to infectious diseases, and toÂ offer improved therapeutic applications for oncology patients.