gebhart/patrepeval huggingface dataset:
Smart Biomaterial Scaffold for In Situ Tissue Regeneration (2012)

Biomaterials are dened as a material or a combination of materials, synthetic or natural in origin, which can be used to repair, replace or model tissues and organs in vitro and in vivo (Clare 2001; Helmus and Tweden 1995; Shi 2003). With advances in the elds of chemistry, biology, and physics, an entirely new, collaborative area of research has identied new biomaterials with improved biological performance (Binyamin et al. 2006). The biomaterials can be classied according to their performance and criteria, such as polymers, metals, ceramics, and composites. Polymers have now contributed to improved quality of life for millions of people worldwide (Binyamin et al. 2006; Dobrzanski 2006; Langer and Tirrell 2004). They represent the most signicant class of biomaterials in medical application, as they can be inert, chemically diverse, processed with ease, and some polymers are resorbable. Polymers can encompass a wide range of physical and chemical properties; they can be used directly, combined with other materials or coated onto surfaces, and they are readily functionalized and can be degraded by the body after a desired period. Additionally, polymers come in many different forms including solids, bers, lms, and gels which provide not only support but also the correct structural architecture essential for tissue regeneration (Nair and Laurencin 2007). As a result, biopolymers are currently the materials of choice for thousands of medical applications.
Application of coordinated beam selection in heterogeneous LTE-advanced networks (2011)

Coordinated Multipoint (CoMP) techniques and heterogeneous wireless networks are two enablers to achieve improvements in data rate both for average as well as cell-edge users. We present a general CoMP technique based on coordinated beam selection and apply this technique in a heterogeneous wireless network where a hexagonal layout of macro base stations is overlaid with clusters of femto cells with closed subscriber group functionality. Without coordination, this scenario can be extremely challenging to mobile users that are located in the vicinity of the femto cells but are not allowed to connect to them. We show that the proposed CoMP technique leads to significant improvements for these users.
Combined Hemoperfusion-Hemodialysis in End-Stage Renal Disease Patients (2023)

Despite advances in dialysis technology, a high level of morbidity and mortality is still present in end-stage renal disease patients undergoing maintenance dialysis. This has been in great part correlated with accumulation of uremic toxins that cannot be adequately removed by classic dialysis membranes and techniques. Improvements have been made in enhancing both membrane permeability and convection rates as in the case for expanded hemodialysis (HD) and hemodiafiltration, but these techniques still present limitations or cannot be performed due to technical reasons. Considering the abovementioned limitations of current dialysis techniques, the additional use of adsorption as a solute removal mechanism may represent an interesting option. Recent studies have underlined the significant improvement in the levels of medium-large retention solutes and toxin-related symptoms using a combination of hemoperfusion with HD at least in a session per week. These studies need further confirmation, but they may represent the doorway to further improve patient's outcome in maintenance dialysis.
Impact of Autologous Dendritic Cell–Based Immunotherapy (AGS-004) on B- and T-Cell Subset Changes and Immune Activation in HIV-Infected Patients Receiving Antiretroviral Therapy (2013)

We previously reported that a combination of antiretroviral therapy with 4 monthly injections of each patient's own autologous dendritic cells (AGS-004) electroporated with CD40 ligand and with HIV RNA antigens obtained from each patient's own pre-antiretroviral therapy plasma induced HIV-specific CD8 T-cell responses in 10 patients. To assess other AGS-004-induced immune changes, we evaluated the modifications in B- and T-cell subsets and the level of immune activation in these patients. The proportion of Bm1 naive cells was increased along with an augmentation of the proliferation marker Ki67. Memory B-cell frequency, CD4 and CD8 T-cell subsets, regulatory T-cell frequency, and CD38/HLA-DR/PD-1 T-cell activation levels remained unchanged after AGS-004 dendritic cell immunotherapy.
Multi-equalization a powerful adaptive filtering for time varying wireless channels (2005)

We propose and analyze a new equalization architecture which uses several equalizers having different structures that perform in parallel. Thus, for this technique, the received signal is filtered by all used equalizers. Then, a selection module chooses the "best" equalized signal based on an appropriate criterion. This scheme allows us to take advantage of several equalization architectures. For a time varying channel with fluctuations of the delay profile and changes in the rapidity of Doppler fading rates, multi-equalization becomes very profitable. In fact, during such communications, channel characteristics vary and so the best equalizer structure to use changes from one moment to the next. The overall performance analysis of the proposed equalization technique over Stanford University interim (SUI) channels was performed. Simulation results show the efficiency of the proposed multi-equalization technique. Error performances of the multi-equalizer combining three different equalizers are significantly better than those of each equalizer taken separately. The proposed strategy permits particularly important performance improvements with some communication scenarios combining either long and short echoes or a variation of fading rates.
Privacy-preserving chi-squared test of independence for small samples (2021)

We propose a new differentially private method, named RandChiDist, for anonymizing χ<sup>2</sup> values for an I×J contingency table with a small number of samples. The experimental results show that RandChiDist outperforms existing methods for small numbers of samples.
Endoscopy essentials: Preparation, sedation, and surveillance (2008)

Journal Article
Optimal budget allocation strategies for real time bidding in display advertising (2015)

We present a simulation model to determine optimal budget allocation strategies for real-time bidding (RTB) based display advertising. A common challenge across RTB exchanges is to optimize both budget spend and performance attainment. Our simulation model uses a stochastic dynamic programming approach based budget allocation to determine budget for each time instant. We report on results from a real-world pilot in which our approach delivered an average 18% performance gain.
Signaling incentive and drive in the primate ventral pallidum for motivational control of goal-directed action (2018)

Abstract Processing incentive and drive is essential for control of goal-directed behavior. The limbic part of the basal ganglia has been emphasized in these processes, yet the exact neuronal mechanism has remained elusive. In this study, we examined the neuronal activity of the ventral pallidum (VP) and its upstream area, the rostromedial caudate (rmCD), while two male macaque monkeys performed an instrumental lever-release task, in which a visual cue indicated the forthcoming reward size. We found that the activity of some neurons in VP and rmCD reflected the expected reward-size transiently following the cue. Reward-size coding appeared earlier and stronger in VP than in rmCD. We also found that the activity in these areas was modulated by the satiation level of monkeys, which also occurred more frequently in VP than in rmCD. The information regarding reward-size and satiation-level was independently signaled in the neuronal populations of these areas. The data thus highlighted the neuronal coding of key variables for goal-directed behavior in VP. Furthermore, pharmacological inactivation of VP induced more severe deficit of goal-directed behavior than inactivation of rmCD, which was indicated by abnormal error repetition and diminished satiation effect on the performance. These results suggest that VP encodes incentive value and internal drive, and plays a pivotal role in the control of motivation to promote goal-directed behavior. Significance Statement The limbic part of the basal ganglia has been emphasized in the motivational control of goal-directed action. Here, we investigated how the ventral pallidum (VP) and the rostromedial caudate (rmCD) encode incentive value and internal drive, and control goal-directed behavior. Neuronal recording and subsequent pharmacological inactivation revealed that VP had stronger coding of reward size and satiation level than rmCD. Reward size and satiation level were independently encoded in the neuronal population of these areas. Furthermore, VP inactivation impaired goal-directed behavior more severely than rmCD inactivation. These results highlighted the central role of VP in the motivational control of goal-directed action.
Measurement of event background fluctuations for charged particle jet reconstruction in Pb-Pb collisions at $ \sqrt {{{s_{\text{NN}}}}} = {2}{.76}\,{\text{TeV}} $ (2012)

A bstract The effect of event background fluctuations on charged particle jet reconstruction in Pb-Pb collisions at $ \sqrt {{{s_{\text{NN}}}}} = {2}{.76}\,{\text{TeV}} $ has been measured with the ALICE experiment. The main sources of non-statistical fluctuations are characterized based purely on experimental data with an unbiased method, as well as by using single high p t particles and simulated jets embedded into real Pb-Pb events and reconstructed with the anti- k t jet finder. The influence of a low transverse momentum cut-off on particles used in the jet reconstruction is quantified by varying the minimum track p t between 0.15 GeV/ c and 2 GeV/ c . For embedded jets reconstructed from charged particles with p t &gt; 0 . 15 GeV/ c , the uncertainty in the reconstructed jet transverse momentum due to the heavy-ion background is measured to be 11.3 GeV/ c (standard deviation) for the 10% most central Pb-Pb collisions, slightly larger than the value of 11.0 GeV/ c measured using the unbiased method. For a higher particle transverse momentum threshold of 2 GeV/ c , which will generate a stronger bias towards hard fragmentation in the jet finding process, the standard deviation of the fluctuations in the reconstructed jet transverse momentum is reduced to 4.8-5.0 GeV/ c for the 10% most central events. A non-Gaussian tail of the momentum uncertainty is observed and its impact on the reconstructed jet spectrum is evaluated for varying particle momentum thresholds, by folding the measured fluctuations with steeply falling spectra.
[Transanal endoscopic microsurgery for rectal intraepithelial neoplasia and early rectal carcinoma]. (2008)

TEM is an ideal minimally invasive procedure for the treatment of rectal IN and early rectal carcinoma, with excellent exposure and accurate excision, providing a high-quality tumor specimen for pathological staging. Pre-operative EUS is very important in selecting patients suitable for resection by TEM.
Stereoselective and nonstereoselective pharmacokinetics of rabeprazole – an overview (2017)

1. Proton pump inhibitors have been extensively used for the treatment of ailments due to increased gastric acid secretion such as peptic ulcers, gastroesophageal reflux disease, etc. 2. There are several approved drugs in the proton pump inhibitor class with the latest entries representing single enantiomer drugs of the previously approved racemic drugs. 3. Despite having a high degree of structural resemblance, rabeprazole, was shown to possess some unique differentiation from other drugs in the class. One of the key distinguishing features of rabeprazole was related to the lesser involvement of polymorphic metabolism in its pharmacokinetic disposition. 4. The review was aimed to provide pharmacokinetic data of rabeprazole from several clinical studies including drug-drug interaction studies where rabeprazole was either a perpetrator drug or victim drug. 5. Additional perspectives on therapy considerations due to the unique metabolic disposition of rabeprazole including the possible issues related to chirality were provided.
Tractable Generative Convolutional Arithmetic Circuits (2016)

Casting neural networks in generative frameworks is a highly sought-after endeavor these days. Contemporary methods, such as Generative Adversarial Networks, capture some of the generative capabilities, but not all. In particular, they lack the ability of tractable marginalization, and thus are not suitable for many tasks. Other methods, based on arithmetic circuits and sum-product networks, do allow tractable marginalization, but their performance is challenged by the need to learn the structure of a circuit. Building on the tractability of arithmetic circuits, we leverage concepts from tensor analysis, and derive a family of generative models we call Tensorial Mixture Models (TMMs). TMMs assume a simple convolutional network structure, and in addition, lend themselves to theoretical analyses that allow comprehensive understanding of the relation between their structure and their expressive properties. We thus obtain a generative model that is tractable on one hand, and on the other hand, allows effective representation of rich distributions in an easily controlled manner. These two capabilities are brought together in the task of classification under missing data, where TMMs deliver state of the art accuracies with seamless implementation and design.
Bit-Stream control of Doubly-Fed Induction Generators (2010)

Bit-Stream based control, which uses one bit wide signals to control power electronics applications, is a new approach for controller design. A Bit-Stream based control system for the Rotor Side Converter (RSC) of a Doubly Fed Induction Generator (DFIG) is proposed to demonstrate that the Bit-Stream control technique is suitable for complex vector control tasks. A new stator flux estimator and reference frame calculation unit are developed and used to control the rotor current of the generator. A 3.7 kW, 400 V generator and Bit-Stream control system are simulated using Mentor Graphics' ModelSim. Simulation results show that the rotor current control system offers decoupled control of the torque and flux producing components of the rotor current vector, and the ability to operate in supersynchronous or subsynchronous modes.
End‐to‐End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation (2013)

Eine Serie von Röhren: Ein kontinuierlicher Prozess für die Herstellung eines Medikaments aus chemischen Intermediaten wird beschrieben. Die Anlage im Pilotmaßstab nutzt viele Vorteile von Flussverfahren, um die aktiven pharmazeutischen Inhaltsstoffe und das Medikament in einem integrierten System herzustellen. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Ex situ formation of oxide-interlayer-mediated-epitaxial CoSi2 film using Ti capping (1999)

A modified oxide mediated epitaxy process using a single deposition and ex situ annealing by Ti capping has been developed in this study. With pure Co on Shiraki oxide, the reaction between Co and Si did not occur even at 800 °C during ex situ annealing, because of the adsorption of oxygen on the Co film. However, when the pure Co on the Shiraki oxide was capped by Ti, a uniform Ti oxide surface layer was formed during the initial stage of annealing, which had a role to eliminate the adsorption of oxygen on the Co film. It led to uniform Co diffusion into the Si substrate through the Shiraki oxide, resulting in epitaxial CoSi2. A good channeling χmin value of 18% comparable to that of the Ti/Co bilayer system was measured in the epitaxial CoSi2 formed from this modified oxide mediated epitaxy process.
ChemInform Abstract: Preparation of the Chiral Diol (2R,3R)‐2‐Hydroxymethyl‐3‐hydroxy‐tetrahydropyran from D‐Glucose via Reductive Rearrangement of Pseudo‐D‐glucal Triacetate. (1986)

Abstract Die Hydrierung des Triacetats (I) unter der angegebenen Bedingung ergibt Gemische aus dem Diacetat (II) und dem Triacetat (III).
Mosaic tetrasomy 12p with triplication of 12p detected by array‐based comparative genomic hybridization of peripheral blood DNA (2007)

A patient whose dysmorphism at birth was not diagnostic for Pallister-Killian syndrome (PKS) was found to have mosaic tetrasomy 12p by an array-based comparative genomic hybridization of peripheral blood DNA. He was determined to be mosaic for 46,XY,trp(12)(p11.2 --> p13) in cultured skin fibroblasts. His appearance was typical for PKS at 4 months of age.
Exacerbation of Granuloma Formation in IL-1 Receptor Antagonist-Deficient Mice with Impaired Dendritic Cell Maturation Associated with Th2 Cytokine Production (2005)

Dendritic cell (DC) maturation at the site of inflammation and migration into draining lymph nodes is fundamental to initiate Ag-specific immune responses. Although several proinflammatory cytokines, including IL-1, are known to promote DC maturation in vitro, their contributions to DC activation and migration within peripheral inflamed tissue compartments are not yet fully understood. We show here that endogenous IL-1 receptor antagonist (IL-1ra) controls the activation state of liver-recruited DCs and their migration in a Propionibacterium acnes-induced murine granulomatous liver disease model. After P. acnes treatment, formation of portal tract-associated lymphoid tissue was conversely impaired in IL-1ra-deficient mice. IL-1ra-deficient mice developed hepatic granulomas within 3 days after P. acnes administration and showed a more pronounced granuloma formation than wild-type mice. Although sinusoidal granulomas contained numerous CD11c+ DCs at day 7, expressions of CCR7, IL-12p40 by these DCs were dramatically decreased in IL-1ra-deficient mice, suggesting aberrant DC maturation and sinusoid portal migration in the absence of endogenous IL-1ra. This was accompanied with enhanced intrahepatic Th2 cytokine production and severe hepatocellular damage. Thus, hepatocyte-derived IL-1ra may control optimal activation and migration of inflammatory DCs within the liver and thereby determine the local immune responses in granulomatous liver disease.
Translational and Vibrational Energy in Cl2 and O2 Plasmas Probed by Innovative Optical Diagnostics (2016)

International audience
Effect of inositol hexaphosphate–loaded red blood cells (RBCs) on the rheology of sickle RBCs (2012)

Our results support the fact that IHP-RBCs could be useful in SCA by decreasing RBC aggregation and blunting the adverse effects of hypoxia on RBC deformability and blood viscosity.
Binary-optics miniature Talbot cavities for laser beam addition (1990)

A miniature external cavity has been fabricated from a single 4.5 mm substrate for coherent beam addition of a linear AlGaAs laser array. Binary-optics elements are fabricated on the front surface for laser beam collimation and onto the back surface for lateral mode selection. Near-diffraction-limited performance has been observed with up to 80% of the far-field power contained in the central lobe.
Channel sparsification beamforming for internet-of-things systems (2017)

In this paper, we propose a novel pilot beamforming and CSI acquisition strategy for IoT systems to achieve reduction in pilot overhead and enhancement in the channel estimation quality. Key idea of the proposed technique, called time-domain sparse beamforming (TDSB), is to sparsify the time-domain channel vector using the antenna-domain beamforming. As a result of TDSB, wideband channel information can be acquired with partial pilot symbols in time and frequency. From the numerical evaluations, we show that the proposed scheme outperforms conventional channel estimation schemes, and achieves substantial reduction in the pilot overhead.
A balanced injection-locked, phase-locked loop array for spectrum analysis (2009)

A balanced ILPLL array is demonstrated to provide an orthogonal basis to estimate the frequency and power of an unknown in-band signal. The opposite loop gains cause the VCOs to be tuned in opposite directions around the injected frequency. The injection frequency is then the average of the two detuned frequencies and the injected amplitude is proportional to the difference in tuning voltages. Low power consumption can be achieved by integrating the balanced ILPLL array on chip.
Life prediction of l6 steel using strain-life curve and cyclic stress-strain curve by means of low cycle fatigue testing (2017)

L6 Steel is used as die material in closed die hot forging process. This material is having some unique properties. These properties are due to its composition. Strain softening is the noticeable property of this material. Due to this in spite of cracking at high stress this material gets plastically deformed and encounters loss in time as well as money. Studies of these properties are necessary to nurture this material at fullest extent. In this paper, numerous experiments have been carried on L6 material to evaluate cyclic Stress - strain behavior as swell as strain-life behavior of the material. Low cycle fatigue test is carried out on MTS fatigue test machine at fully reverse loading condition R=-1. Also strain softening effect on forging metal forming process is explained in detail. The failed samples during low cycle fatigue test further investigated metallurgically on scanning electron microscopy. Based on this study, life estimation of hot forging die is carried out and it's correlation with actual shop floor data is found out. This work also concludes about effect of pre-treatments like nitro-carburizing and surface coating on L6 steel material, to enhance its fatigue life to certain extent.