gebhart/patrepeval huggingface dataset:
Mid‐term Follow‐Up of Endocardial Biventricular Pacing (2000)

Biventricular (BV) pacing is a promising treatment of end-stage heart failure. This article describes our experience with a strictly endocardial BV pacing system in patients with severe congestive heart failure. Three women and eight men (age 65 +/- 9 years) with drug-resistant end-stage CHF underwent implantation of an endocardial BV pacing system. In the first seven patients, the left ventricular lead was placed via a combined femoral and internal jugular approach. In the last four patients, the transseptal puncture was directly performed via the right internal jugular vein with a dedicated kit. The procedure was successful in all 11 patients. The acute left ventricular and BV thresholds were 1.3 +/- 0.6 V and 2.4 +/- 1 V, respectively. The QRS duration decreased from 214 +/- 57 to 176 +/- 25 ms. A functional improvement was noted in ten patients with a decrease in mean NYHA functional class from 3.7 +/- 0.5 before, to 2.6 +/- 0.9 after system implantation. A significant decrease in pulmonary capillary wedge pressure and increase in cardiac output were measured in eight patients. During follow-up, four patients died from CHF (n = 3) or ventricular fibrillation (n = 1). Under oral anticoagulation, no thromboembolic event was observed but one transient ischemic attack occurred in one patient whose anticoagulation was interrupted. Endocardial BV pacing is technically feasible and appears safe, though further studies are needed before it is used on a longer scale.
Metronomic ABI-007 therapy: antiangiogenic and antitumor activity of a nanoparticle albumin-bound paclitaxel (2005)

2988 Background: Metronomic chemotherapy, the low-dose and frequent administration of cytotoxic agents without prolonged drug-free breaks, is believed to target activated endothelial cells in the tumor vasculature. A number of preclinical studies have demonstrated the superior antitumor efficacy and the reduced toxicity of some metronomic regimens compared to their maximum tolerated dose (MTD) counterparts. It remains unclear whether all chemotherapeutic drugs exert similar effects or whether some are better suited for such regimens than others. Paclitaxel has been shown to inhibit angiogenesis when used at very low doses (Grant et al., Int. J. Cancer, 2003). However, it was also reported that clinically relevant concentrations of the formulation vehicle cremophor EL in Taxol nullify the antiangiogenic activity of paclitaxel, suggesting that this agent or other anticancer drugs formulated in cremophor EL may need to be used at much higher doses than anticipated to achieve effective metronomic chemotherapy (Ng et al., Cancer Res., 2004). As such, the advantage of the lack of undesirable side effects associated with low-dose paclitaxel regimens vs. conventional MTD chemotherapy may be compromised. ABI-007, a cremophor EL-free nanoparticle paclitaxel, could potentially alleviate the problem. Methods: The antiangiogenic activity of ABI-007 was assessed by the rat aortic ring, human umbilical vein endothelial cell (HUVEC) proliferation and tube formation assays. Optimal dose of ABI-007 for metronomic therapy was determined by measuring the levels of circulating endothelial progenitors (CEPs) in peripheral blood of Bal/c non-tumor bearing mice (n=5/ group; dosing: 1-30 mg/kg, i.p, qdx7) with flow cytometry (Shaked et al., Cancer Cell, in press). Subsequently, the antitumor effects of metronomic (qd; i.p.) and MTD (qdx5, 1 cycle; i.v.) ABI-007 and Taxol were evaluated and compared in SCID mice bearing human MDA-MD-231 breast and PC3 prostate cancer xenografts. Results: ABI-007 at 5 nM significantly (P
Logical vs. physical disk shadowing (2002)

Summary form only given. Bitton and Gray (1988) have defined disk shadowing as a technique for maintaining a set of two or more identical disk images on separate disk drives. Its primary purpose is to enhance reliability and availability of secondary storage by providing multiple paths to redundant data. The current paper demonstrates how disk shadowing can be further improved if not physical page images but logical data sets are mirrored with different clustering strategies on different disks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Brain astrocytes express region‐specific surface glycoproteins in culture (1988)

Astrocytes derived from the mouse brain mesencephalon and striatum regulate neuronal morphogenesis in a region-specific manner in vitro. To begin defining molecular mechanisms that may underlie this functional heterogeneity, lectin probes were used to compare surface glycoproteins expressed by astrocytes from different brain regions. These experiments demonstrated marked differences in surface glycoproteins depending on the anatomic origin of the astrocytes. In particular, mesencephalic and cerebellar astrocytes express a fucosylated glycoprotein with an apparent molecular weight of 190 kD that is absent or rarely expressed by striatal or cortical astrocytes. These findings raise the possibility that carbohydrate diversity of astrocyte surface molecules may play a role in the heterogeneity of region-specific neuron-glial interactions.
ChemInform Abstract: Antibiotics from Basidiomycetes. Part 45. Caloporoside, a New Inhibitor of Phospholipase C from Caloporus dichrous (Fr.) Ryv. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Structural Elucidation of Glycosaminoglycans (2008)

There is accumulating evidence of the importance of linear polysaccharides in modulating biological phenomena in both the normal and the diseased states. This layer of regulation results from interactions between polysaccharides and other biomolecules, such as proteins, at the cell-extracellular matrix interface. The specific sequence of chemical modifications within the polymer backbone imparts a potential for interaction with other molecular species, and thus there exists important information within the various sulfation, acetylation, and epimerization states of such complex carbohydrates. A variety of factors have made the deciphering of this chemical code elusive. To this end, this report describes several techniques to elucidate the structural information inherent in glycosaminoglycan species. First, the use of depolymerizing enzymes that cleave polysaccharides at specific sites is described. Then, capillary electrophoretic (CE) techniques are employed to characterize the disaccharide species present in an enzymatically-cleaved polysaccharide sample. Mass spectrometry (MS) procedures can further be used to establish the length of an oligosaccharide chain and the presence of specific functional groups.
Focused electron beam induced etching and in-situ monitoring: Fabrication of sub-beam sized nanoholes (2007)

In this work, the control of focused ion beam induced deposition (FEBIE) process is examined through fabrication of nanoholes on 10-nm-thin amorphous carbon (a-C) membrane using H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O and XeF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> precursor, and its in-situ stage current measurement. Nanoholes with diameters smaller than the beam size were successfully obtained. Results indicate the feasibility of fabrication of nanoholes with sub-nm diameter in the future.
Study of the performance of RPS (1976)

The objective of this study is to evaluate the impact of RPS (Rotational Position Sensing) on the response time and utilization of multiple spindle disk drives with a shared channel. Simulation models are used to compare the effectiveness of the RPS scheme with the systems without RPS capability. Analytical models for the number of RPS rotation misses and the utilization of the channel at the saturation point are given.
Impact of spillover from white matter by partial volume effect on quantification of amyloid deposition with [11C]PiB PET (2016)

High non-specific uptake of [<sup>11</sup>C]Pittsburgh compound B ([<sup>11</sup>C]PiB) in white matter and signal spillover from white matter, due to partial volume effects, confound radioactivity measured in positron emission tomography (PET) with [<sup>11</sup>C]PiB. We aimed to reveal the partial volume effect in absolute values of kinetic parameters for [<sup>11</sup>C]PiB, in terms of spillover from white matter. Dynamic data acquired in [<sup>11</sup>C]PiB PET scans with five healthy volunteers and eight patients with Alzheimer's disease were corrected with region-based and voxel-based partial volume corrections. Binding potential (BP<sub>ND</sub>) was estimated using the two-tissue compartment model analysis with a plasma input function. Partial volume corrections significantly decreased cortical BP<sub>ND</sub> values. The degree of decrease in healthy volunteers (-52.7±5.8%) was larger than that in Alzheimer's disease patients (-11.9±4.2%). The simulation demonstrated that white matter spillover signals due to the partial volume effect resulted in an overestimation of cortical BP<sub>ND</sub>, with a greater degree of overestimation for lower BP<sub>ND</sub> values. Thus, an overestimation due to partial volume effects is more severe in healthy volunteers than in Alzheimer's disease patients. Partial volume corrections may be useful for accurately quantifying Aβ deposition in cortical regions.
Qiskit Backend Specifications for OpenQASM and OpenPulse Experiments (2018)

As interest in quantum computing grows, there is a pressing need for standardized API's so that algorithm designers, circuit designers, and physicists can be provided a common reference frame for designing, executing, and optimizing experiments. There is also a need for a language specification that goes beyond gates and allows users to specify the time dynamics of a quantum experiment and recover the time dynamics of the output. In this document we provide a specification for a common interface to backends (simulators and experiments) and a standarized data structure (Qobj --- quantum object) for sending experiments to those backends via Qiskit. We also introduce OpenPulse, a language for specifying pulse level control (i.e. control of the continuous time dynamics) of a general quantum device independent of the specific hardware implementation.
Percolation and binding of monoclonal antibody BW494 to pancreatic carcinoma tissues during high dose immunotherapy and consequences for future therapy modalities. (1990)

The distribution of the monoclonal antibody (MAb) BW494 in human pancreatic carcinoma biopsies during high dose intravenous immunotherapy was investigated. Using immunohistochemical techniques combined with anti-idiotypic, endothelial cell-specific and bispecific MAbs, it was shown that 3 days after onset of immunotherapy, MAb BW494 was bivalently bound to tumour cells in some highly vascularised areas near capillaries. No binding was observed in other highly vascularised tumour cell areas although the epitope detected by MAb BW494 was present. In contrast to our expectation the majority of the tumour cells were not yet saturated by the antibody, probably due to diffusion barriers in the solid tumour tissue.
Object-Oriented Modeling and Control of Delta Robots (2018)

In this paper we derive a dynamic model of the Delta robot that is well-suited to an object-oriented modeling framework. The approach uses an augmented Lagrangian or Hamiltonian formulation together with Baumgarte's method of index reduction, and results in a singularity-free dynamic model that is well suited to dynamic analysis, control system synthesis and time-domain simulation. The object-oriented structure enables broad application to problems such as coordinated control and robotic assembly. We present several common control algorithms and conduct a dynamic analysis of the Delta robot that shows that the open-loop system is unstable for large volumes of the reachable workspace, which has fundamental implications on closed-loop performance.
A case study of software process improvement during development (1993)

We present a case study of the use of a software process improvement method which is based on the analysis of defect data. The first step of the method is the classification of software defects using attributes which relate defects to specific process activities. Such classification captures the semantics of the defects in a fashion which is useful for process correction. The second step utilizes a machine-assisted approach to data exploration which allows a project team to discover such knowledge from defect data as is useful for process correction. We show that such analysis of defect data can readily lead a project team to improve their process during development.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Polymer Optical Waveguide Chip: New Tool for Simple Evaluation of Optical Parameters of Waveguide Elements (2010)

A polymer optical chip consisting of 45°-angled cut straight waveguides, Y-splitters, and S-bend waveguides was designed and fabricated to examine a simple evaluation of multimode waveguides. Appropriate input condition was investigated for standardization of an evaluation method of optical characteristics of multimode waveguides.
Stimulation of DNA Strand Exchange by the Human TBPIP/Hop2-Mnd1 Complex (2006)

In Saccharomyces cerevisiae, the Hop2 protein forms a complex with the Mnd1 protein and is required for the alignment of homologous chromosomes during meiosis, probably through extensive homology matching between them. The Rad51 and Dmc1 proteins, the eukaryotic RecA orthologs, promote strand exchange and may function in the extensive matching of homology within paired DNA molecules. In the present study, we purified the human TBPIP/Hop2-Mnd1 complex and found that it significantly stimulates the Dmc1- and Rad51-mediated strand exchange. The human Hop2-Mnd1 complex preferentially binds to a three-stranded DNA branch, which mimics the strand-exchange intermediate. These findings are consistent with genetic data, which showed that the Hop2 and Mnd1 proteins are required for homology matching between homologous chromosomes. Therefore, the human TBPIP/Hop2-Mnd1 complex may ensure proper pairing between homologous chromosomes through its stimulation of strand exchange during meiosis.
Expression of hepatitis C virus-derived core or NS3 antigens in human dendritic cells leads to induction of pro-inflammatory cytokines and normal T-cell stimulation capabilities (2005)

The majority of hepatitis C virus (HCV)-infected individuals become chronically infected, which can result in liver cirrhosis and hepatocellular carcinoma. Patients with chronic HCV are unable to prime and maintain vigorous T-cell responses, which are required to rid the body of the viral infection. Dendritic cells (DCs) are the professional antigen-presenting cells that probably play a dominant role in priming and maintaining vigorous T-cell responses in HCV infection. Furthermore, inefficient DC function may play an important role in HCV chronicity. In order to determine the effect of HCV NS3 and core proteins on phenotype and function of human DCs, recombinant adenoviral vectors containing NS3 or core genes were used to infect human DCs. HCV NS3- or core-protein expression in DCs was confirmed by Western blotting and immunofluorescence staining. The DCs expressing HCV NS3 or core proteins expressed several inflammatory cytokine mRNAs, had a normal phenotype and effectively stimulated allogeneic T cells, as well as T cells specific for another foreign antigen (tetanus toxoid). These findings are important for rational design of cellular-vaccine approaches for the immunotherapy of chronic HCV.
Compressive Sensing and Morphology Singular Entropy-Based Real-time\n Secondary Voltage Control of Multi-area Power Systems (2018)

This paper presents an improved secondary voltage control (SVC) methodology\nincorporating compressive sensing (CS) for a multi-area power system. SVC\nminimizes the voltage deviation of the load buses while CS deals with the\nproblem of the limited bandwidth capacity of the communication channel by\nreducing the size of massive data output from phasor measurement unit (PMU)\nbased monitoring system. The proposed strategy further incorporates the\napplication of a Morphological Median Filter (MMF) to reduce noise from the\noutput of the PMUs. To keep the control area secure and protected locally,\nMathematical Singular Entropy (MSE) based fault identification approach is\nutilized for fast discovery of faults in the control area. Simulation results\nwith 27-bus and 486-bus power systems show that CS can reduce the data size up\nto 1/10th while the MSE based fault identification technique can accurately\ndistinguish between fault and steady state conditions.\n
A new approach to the modeling and simulation of flexible microstructures under the effect of squeeze-film damping (2003)

We present a new approach to the modeling and simulation of flexible microstructures under the effect of squeeze-film damping. Our approach utilizes the compressible Reynolds equation coupled with the equation governing the plate deflection. The model accounts for the electrostatic forcing of the capacitor airgap, the restoring force of the microplate and the applied in-plane loads. It also accounts for the slip condition of the flow at very low pressures. Perturbation methods are used to derive an analytical expression for the pressure distribution in terms of the structural mode shapes. This expression is substituted into the plate equation, which is solved in turn using a finite-element method for the structural mode shapes, the pressure distributions, the natural frequencies and the quality factors. We apply the new approach to a variety of rectangular and circular plates and present the final expressions for the pressure distributions and quality factors. Our theoretically calculated quality factors are in excellent agreement with available experimental data and hence our methodology can be used to simulate accurately the dynamics of flexible microstructures and predict their quality factors under a wide range of gas pressures. Because the pressure distribution is related analytically to the deflection, the dimension of the coupled structural-fluidic problem and hence the number of global variables needed to describe the dynamics of the system is reduced considerably. Consequently, the new approach can be significant to the development of computationally efficient CAD tools for microelectromechanical systems.
Origin of giant graphite balls including in the carbon nanohorns prepared by pulsed arc-discharge and their removal method (2008)

Large sized spherical graphitic particles with the diameter as large as several micrometers, so called giant graphite balls (GGBs), are more or less included in the sample of carbon nanohorns (CNHs) which are prepared by the method of pulsed arc-discharge or laser ablation. For the use of CNHs in the application, it is needed to decrease such impurity from the sample. In order to find a way to decrease the GGBs content, we investigate the origin of GGBs and find a simple method for increasing the sample purity. The origin of GGBs is the exfoliated materials from the carbon rod, and such an exfoliation can be nearly avoided by the preheat treatment of the carbon rod up to 1000°C just in advance of the arc vaporization. According to this preheat, the quantity of GGBs in the sample can be reduced from 30 to 0.01 % (100 ppm) by weight. In addition, it was found that the simple two-staged purification which is combined with the centrifugation and filtration effectively works for removing such a small quantity of GGBs.
Aberrant ZNF423 impedes B cell differentiation and is linked to adverse outcome of ETV6-RUNX1 negative B precursor acute lymphoblastic leukemia (2013)

Differentiation arrest is a hallmark of acute leukemia. Genomic alterations in B cell differentiation factors such as PAX5, IKZF1, and EBF-1 have been identified in more than half of all cases of childhood B precursor acute lymphoblastic leukemia (ALL). Here, we describe a perturbed epigenetic and transcriptional regulation of ZNF423 in ALL as a novel mechanism interfering with B cell differentiation. Hypomethylation of ZNF423 regulatory sequences and BMP2 signaling result in transactivation of ZNF423α and a novel ZNF423β-isoform encoding a nucleosome remodeling and histone deacetylase complex-interacting domain. Aberrant ZNF423 inhibits the transactivation of EBF-1 target genes and leads to B cell maturation arrest in vivo. Importantly, ZNF423 expression is associated with poor outcome of ETV6-RUNX1-negative B precursor ALL patients. Our work demonstrates that ALL is more than a genetic disease and that epigenetics may uncover novel mechanisms of disease with prognostic implications.
Supplementary Figure 9 from Aging of Preleukemic Thymocytes Drives CpG Island Hypermethylation in T-cell Acute Lymphoblastic Leukemia (2023)

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Self-Assembled Squalenoylated Penicillin Bioconjugates: An Original Approach for the Treatment of Intracellular Infections (2012)

We describe here new nanoparticles based on the bioconjugation of penicillin G to squalene in order to overcome severe intracellular infections by pathogen bacteria whose mechanism of resistance arises from the poor intracellular diffusion of several antibiotics. Two different squalene-penicillin G conjugates were synthesized (pH-sensitive and pH-insensitive), and their self-assembly as nanoparticles was investigated through morphology and stability studies. These nanoparticles had a size of 140 ± 10 nm (polydispersity index of 0.1) and a negative charge, and they did not display any supramolecular organization. Furthermore, they were found stable in water and in different culture medium. The cellular uptake and localization of these fluorescently labeled nanoparticles were explored on the macrophage cell line J774 by flow cytometry and confocal microscopy analysis. The squalenoylated nanoparticles were found to be cell internalized through clathrin-dependent and -independent endocytic pathways. Moreover, they induced an improved intracellular antibacterial activity on the facultative intracellular pathogen S. aureus, compared with free penicillin G, despite the absence of co-localization between the bacteria and the nanoparticles in the cells. This study suggests that the bioconjugation of an antibiotic to a squalene template could be a valuable approach for overcoming the antibiotic resistance due to intracellular bacterial infections.