gebhart/patrepeval huggingface dataset:
The XG-PON System: Cost Effective 10 Gb/s Access (2010)

The ten gigabit passive optical network (XG-PON) system is the newest member of the ITU-T family of passive optical network standards. XG-PON is the result of a 3 year project involving the full service access network (FSAN) group and ITU-T study group 15 (SG15) question 2. This paper reviews the deliberations that led to the selection of the XG-PON system, and then explains the three primary layers of the system: physical, protocol, and management. The paper concludes with information on standards and implementations of the system, and on future work in this area.
Understanding requirements and issues in disaster area using geotemporal visualization of Twitter analysis (2020)

During disasters, requirements and situations on the ground change very rapidly. Moreover, they depend on timing and location; thus, it is very hard to understand them in a timely manner. Social media may contain such information with the posted time and the location information. However, it is difficult to extract situational requirements from numbers of conflicting sources. In this article, we propose a system that enables us to find out such useful information from social media and visualize it to understand the data easily. The system is divided into two steps. The first step is to extract requirements and issues from textual data, such as “We cannot buy gas here” or “We are short of batteries,” using natural language processing (NLP) technologies. The system also uses NLP to extract geolocation information, such as city names and location landmarks. The second step is to visualize the results in a timely and geolocated manner. We show the system results with using real Twitter data from the Kumamoto Earthquake in 2016. By visualizing the information, the personnel in the disaster area, such as the local governments and/or volunteer organizations, can utilize this information very effectively. For instance, they can decide how to distribute food and water in the disaster area and also how to implement and responsed to their logistics.
Epoxide-Opening Cascades Promoted by Water (2007)

Selectivity rules in organic chemistry have been inferred largely from nonaqueous environments. In contrast, enzymes operate in water, and the chemical effect of the medium change remains only partially understood. Structural characterization of the "ladder" polyether marine natural products raised a puzzle that persisted for 20 years: Although the stereochemistry of adjacent tetrahydropyran (THP) cycles would seem to arise from a biosynthetic cascade of epoxide-opening reactions, experience in organic solvents argued consistently that such a pathway would be kinetically disfavored. We report that neutral water acts as an optimal promoter for the requisite ring-opening selectivity, once a single templating THP is appended to a chain of epoxides. This strategy offers a high-yielding route to the naturally occurring ladder core and highlights the likely importance of aqueous-medium effects in underpinning certain noteworthy enzymatic selectivities.
Position Selective Beam Shaping in Mid-Infrared Regime by All-Dielectric Metasurfaces (2018)

We demonstrate the design, fabrication and experimental characterization of a dielectric metasurfaces acting as a position selective computer generated hologram operating at mid infrared wavelength of 4.5 micron.
Abstract A46: Wnt5a signals through DVL1 to repress ribosomal DNA transcription by RNA polymerase I (2017)

Abstract Ribosome biogenesis is essential for cell growth and proliferation and is commonly elevated in cancer. Accordingly, numerous oncogene and tumor suppressor signaling pathways target rRNA synthesis. In breast cancer, non-canonical Wnt signaling by Wnt5a has been reported to antagonize tumor growth. Here, we show that Wnt5a rapidly represses rDNA gene transcription in breast cancer cells and generates a chromatin state with reduced transcription of rDNA by RNA polymerase I (Pol I). These effects were specifically dependent on Dishevelled1 (DVL1), which accumulates in nucleolar organizer regions (NORs) and binds to rDNA regions of the chromosome. Upon DVL1 binding, the Pol I transcription activator and deacetylase Sirtuin 7 (SIRT7) releases from rDNA loci, concomitant with disassembly of Pol I transcription machinery at the rDNA promoter. These findings reveal that Wnt5a signals through DVL1 to suppress rRNA transcription. This provides a novel mechanism for how Wnt5a exerts tumor suppressive effects and why disruption of Wnt5a signaling enhances mammary tumor growth in vivo. Note: This abstract was not presented at the conference. Citation Format: Randall Dass, Aishe Sarshad, Brittany Carson, Jennifer Feenstra, Amanpreet Kaur, Ales Obrdlik, Matthew Parks, Varsha Prakash, Damon Love, Kristian Pietras, Rosa Serra, Scott Blanchard, Piergiorgio Percipalle, Anthony Brown, Clara Theresa Vincent. Wnt5a signals through DVL1 to repress ribosomal DNA transcription by RNA polymerase I. [abstract]. In: Proceedings of the AACR Special Conference on Translational Control of Cancer: A New Frontier in Cancer Biology and Therapy; 2016 Oct 27-30; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2017;77(6 Suppl):Abstract nr A46.
Wnt Signaling Regulates Airway Epithelial Stem Cells in Adult Murine Submucosal Glands (2016)

Wnt signaling is required for lineage commitment of glandular stem cells (SCs) during tracheal submucosal gland (SMG) morphogenesis from the surface airway epithelium (SAE). Whether similar Wnt-dependent processes coordinate SC expansion in adult SMGs following airway injury remains unknown. We found that two Wnt-reporters in mice (BAT-gal and TCF/Lef:H2B-GFP) are coexpressed in actively cycling SCs of primordial glandular placodes and in a small subset of adult SMG progenitor cells that enter the cell cycle 24 hours following airway injury. At homeostasis, these Wnt reporters showed nonoverlapping cellular patterns of expression in the SAE and SMGs. Following tracheal injury, proliferation was accompanied by dynamic changes in Wnt-reporter activity and the analysis of 56 Wnt-related signaling genes revealed unique temporal changes in expression within proximal (gland-containing) and distal (gland-free) portions of the trachea. Wnt stimulation in vivo and in vitro promoted epithelial proliferation in both SMGs and the SAE. Interestingly, slowly cycling nucleotide label-retaining cells (LRCs) of SMGs were spatially positioned near clusters of BAT-gal positive serous tubules. Isolation and culture of tet-inducible H2B-GFP LRCs demonstrated that SMG LRCs were more proliferative than SAE LRCs and culture expanded SMG-derived progenitor cells outcompeted SAE-derived progenitors in regeneration of tracheal xenograft epithelium using a clonal analysis competition assay. SMG-derived progenitors were also multipotent for cell types in the SAE and formed gland-like structures in xenografts. These studies demonstrate the importance of Wnt signals in modulating SC phenotypes within tracheal niches and provide new insight into phenotypic differences of SMG and SAE SCs. Stem Cells 2016;34:2758-2771.
Dental needs and conditions of individuals with Lowe syndrome: An observational study (2023)

The findings of this study indicate that individuals with LS are more vulnerable to developing severe dental conditions and experiencing difficulties in accessing dental care than healthy individuals. Additionally, those who present with this syndrome may be less likely to receive specific necessary dental treatments. As a result, it is essential to offer appropriate dental care and support to individuals with LS to guarantee they achieve optimal oral health.
Simulating Motion - Incorporating Spatial Consistency into the NYUSIM Channel Model (2018)

This paper describes an implementation of spatial consistency in the NYUSIM channel simulation platform. NYUSIM is a millimeter wave (mmWave) channel simulator that realizes measurement-based channel models based on a wide range of multipath channel parameters, including realistic multipath time delays and multipath components that arrive at different 3-D angles in space, and generates life-like samples of channel impulse responses (CIRs) that statistically match those measured in the real world. To properly simulate channel impairments and variations for adaptive antenna algorithms or channel state feedback, channel models should implement spatial consistency which ensures correlated channel responses over short time and distance epochs. The ability to incorporate spatial consistency into channel simulators will be essential to explore the ability to train and deploy massive multiple-input and multiple-output (MIMO) and multi-user beamforming in next-generation mobile communication systems. This paper reviews existing modeling approaches to spatial consistency, and describes an implementation of spatial consistency in NYUSIM for when a user is moving in a square area having a side length of 15 m. The spatial consistency extension will enable NYUSIM to generate realistic evolutions of temporal and spatial characteristics of the wideband CIRs for mobile users in motion, or for multiple users who are relatively close to one another.
Comparison of strength properties of normotensive and hypertensive rat pulmonary arteries. (2004)

A series of tests were conducted to quantify the difference in the mechanical properties of normo- and hypertensive pulmonary arteries. A bubble-test design was employed to measure the biaxial properties of a segment of artery. The test results compare the properties at multiple orientations of the trunk, right, and left pulmonary arteries from normal (Control) and monocrotaline-treated male Long-Evans wild rats that ranged in age from 8 to 17 weeks old, along with some preliminary results from hypoxic Long-Evans knock-out rats. Data show little difference between the stress-strain relationship of the control pulmonary arteries and that of the monocrotaline-treated pulmonary arteries. However, the preliminary results from the hypoxic pulmonary arteries show that the arterial material strains less before the onset of strain-stiffening behavior. The longitudinal orientation exhibits strain stiffening at lower strains than does the circumferential orientation. The differences between the left and right main arteries are minor. The trunk consistently demonstrates less stiffening in the region of larger strains for all conditions.
Differential expression and regulation of the human CD8α and CD8β chains (1990)

The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The majority of monoclonal antibodies (mAb) reactive with the human CD8 antigen bind the CD8 alpha chain, while a single mAb, T8/2T8-5H7, has been identified which binds to the CD8 alpha/beta heterodimer. While the two chains of CD8 have been presumed to be coordinately expressed in normal T cells, this is not always the case. Northern blot analysis of a panel of T-cell leukemias and normal cells demonstrate that CD8 alpha and CD8 beta are not invariably co-transcribed and phenotypic analysis of fresh and interleukin 2 (IL-2) expanded peripheral blood mononuclear cells (PBMC) confirm that the CD8 alpha and CD8 beta chains are differentially expressed at the cell surface. Four distinct subpopulations of CD8+ cells have been identified based on the expression of CD8 alpha/alpha or CD8 alpha/beta complexes: (1) T-cell receptor (TcR) alpha beta+ T cells which are CD8 alpha+/beta+; (2) TcR alpha beta+ T cells which are CD8 alpha+/beta-; (3) TcR gamma delta+ T cells which are CD8 alpha+/beta- and (4) natural killer (NK) cells which are CD8 alpha+/beta-. We also demonstrate the down-regulation of the CD8 alpha/beta heterodimers from the surface of a CD8+ T-cell clone following treatment with phorbol myristate acetate (PMA) while CD8 alpha/alpha homodimers remain on the cell surface. This observation demonstrates that a) a CD8+ T-cell clone can express both CD8 alpha/alpha homodimers and CD8 alpha/beta heterodimers and b) these two complexes do not have identical biological properties. Together, these data suggest that CD8 alpha/alpha and CD8 alpha/beta dimers may not subserve identical functions. The differential contribution of these two CD8 complexes should be considered in models of T-cell-mediated cytotoxicity and T-cell activation.
Highlights of the DNA Vaccines 2011 Meeting (2012)

In July 2011, DNA vaccine researchers from the world over met once again to present and discuss their research at the 2011 DNA Vaccine meeting held July 12–14 in beautiful San Diego, CA along scenic Coronado Bay. This meeting, presented under the auspices of the International Society of DNA Vaccines, centered on the theme of “Building on Clinical Progress and Exploring New Targets”.

This provocative meeting covered studies on a number of important immunotherapy and vaccine targets, including those for infectious agents as well as those for non-infectious diseases. A number of these studies are included in the special issue highlighting the presentations made at this meeting. As well, we are very pleased to have the opportunity to present these papers in a peer-reviewed Special Issue of the excellent journal Human Vaccines & Immunotherapeutics.

In this issue a number of important viral infectious agents are targeted, i.e., human immunodeficiency virus (HIV), cytomegalovirus (CMV) and Ebola. Bacterial and parasitic agents also were targeted, as exemplified by the papers included in this issue on Staphylococcus aureus andmalaria, respectively. Likewise, several cancer immunotherapy papers targeting melanoma are highlighted.

There has also been a continued interest and effort in the field to utilize immune co-stimulatory molecules to further drive the potential efficacy of DNA vaccines and immunotherapeutics. This is exemplified by papers in this issue using interleukin-12 (IL-12), CCL25 chemokine, granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-28 (IL-28). Importantly, the use of these immunomodulatory agents has been applied to infectious agents as well as cancer. Lastly, there has been a continued interest and work in the area of applying “forcing” methods to assist the DNA to get into cells, with subsequent enhanced expression and associated biological activity. This is exemplified by presentations that include the use of in vivo electroporation as well as more novel delivery methods such as magneto-permeabilization and helium plasma, both of which are contact-independent modalities. All of these studies, as well as the others presented at the conference, have the important role of further documenting and potentially validating the clinical potential of the DNA plasmid vaccine and immunotherapy technology.

In sum, we look forward to welcoming you and your colleagues back to San Diego in December 2012 for the next DNA Vaccines Meeting, which of note will occur 20 years after the first reports of the ability of genes expressed from naked DNA plasmids to induce relevant immune responses against some important infectious agents. We hope that this meeting will again be a productive and provocative venue with publication opportunities to further push the recent advancements of DNA plasmids in the vaccine and immunotherapy arenas to their full clinical potential. San Diego, here we come again! Hope to see you all there!

Sincerely,

Kenneth E. Ugen PhD

Guest Editor

David B. Weiner PhD

Guest Editor
Long‐term follow‐up of 3‐month neoadjuvant hormone therapy before radical prostatectomy in a randomized trial (2009)

Although our study was not originally powered to detect differences in BCR, there was no overall benefit in BCR-free probability, local recurrence or metastasis with 3 months of NHT at 8 years of follow-up. Pending evidence of improvement in patient outcomes, NHT before RP appears to be unjustified outside of clinical trials.
Impedance Reducing Additives and Their Effect on Cell Performance (2012)

Wound LiCoO2/graphite and Li[Ni0.42Mn0.42Co0.16]O2 (NMC)/graphite cells with 1 M LiPF6 in EC:EMC (3:7 by wt) electrolyte containing 2 wt% vinylene carbonate (VC) and/or 0.3 wt% trimethoxyboroxine (TMOBX) were studied using the High Precision Charger at Dalhousie University, automated cycling/storage, AC impedance and long-term cycling at elevated temperature. The additive, VC, improves lifetime performance by increasing coulombic efficiency and decreasing charge and discharge end point capacity slippage. The impact of TMOBX on cell performance depends on electrolyte and electrode choices within the cell. When TMOBX is added to control electrolyte in LiCoO2/graphite cells, the cycle life is improved and the impedance reduced. When added to VC-containing electrolyte the impedance is also reduced with the impact on lifetime not being clear at this time. When TMOBX is added to NMC/graphite cells with control electrolyte the impedance is decreased but when added to VC-containing electrolyte the impedance is unchanged. The impact on cycle life when TMOBX is added to NMC/graphite cells is a decrease in capacity fade but a lower measured coulombic efficiency. Therefore TMOBX appears to be an interesting additive with potential to decrease impedance and/or extend cycle life based on the electrolyte formulation and electrodes used in a Li-ion cell.
Variable magnetization pattern machines (2017)

This paper presents variable magnetization pattern machines that have a capability to control the spatial property of magnetization patterns in permanent magnets by intentional dynamic demagnetization during operation. These machines can effectively reduce the unwanted property caused by the spatial harmonic magnetic flux density, such as the iron losses and torque ripple, since they can greatly reduce the source of the harmonics in the rotor magnetomotive force (MMF). The principle of magnetization pattern change, the limitations regarding the applicable machine type, and the machine performance comparison with and without magnetization pattern shaping are discussed.
Alteration of gene expression in human cumulus cells as a potential indicator of oocyte aneuploidy (2012)

In the current study, SPSB2 and TP53I3 exhibited highly significant differences in their expression between CCs of normal and chromosomally abnormal oocytes. SPSB2 is involved in intracellular signalling and homeostasis, whereas TP53I3 regulates carbohydrate metabolism and apoptosis. We speculate that both these genes might have the potential to serve as non-invasive markers of oocyte aneuploidy.
Mapping the progression of resection continuously during brain tumor surgery (2021)

<i>Objective:</i> This purpose of this study was to develop and validate methods for monitoring the progression of resection during the neurosurgical removal of brain tumors. <i>Methods:</i> An optical tracking array was attached to a surgical instrument to track its tip position relative to preoperative imaging. The tip position was monitored continuously during surgery and used to generate a map of resection progression in the form of a 3D distance field. This method was validated on 18 brain phantoms by comparing resection maps to 3D ultrasound acquired before and after resection. A clinically compatible workflow was iteratively developed and optimized during more than 15 clinical cases with input and feedback from two neurosurgeons. <i>Results:</i> Phantom studies showed that resection maps accurately model the actual resection cavity, with an average of 97.5% of voxels inside the actual resection cavity lying within 2 mm of the resection map and an average of 94.7% of tracked resection points lying within 2 mm of the actual resection cavity. In clinical workflow studies, a variety of surgical instruments were tracked continuously with minimal disruption to surgery. Preliminary clinical data demonstrated that the resection map can be used to flag brain shift and predict residual tumor. <i>Conclusion:</i> Continuous monitoring of the progression of brain tumor resection can be done accurately and with minimal disruption in the operating room. <i>Significance:</i> Providing a real-time map of resection progression will reduce the cognitive load on neurosurgeons and facilitate more complete resections, particularly during long, complex surgeries.
All-optical modulation via nonlinear cascading in type II second-harmonic generation (1995)

Utilizing a type II interaction for second-harmonic generation in a crystal of potassium titanyl phosphate, we experimentally demonstrate the all-optical action of a light modulator with both signal and output at the same optical wavelength. This modulator is controlled by the intensity of the injected signal, a characteristic that makes it a suitable candidate for all-optical transistor action and ultrafast analog processing in transparent networks for telecommunications.
Combined Supplementary Data from FS222, a CD137/PD-L1 Tetravalent Bispecific Antibody, Exhibits Low Toxicity and Antitumor Activity in Colorectal Cancer Models (2023)

&lt;p&gt;All supplementary figures and tables within one powerpoint document&lt;/p&gt;
Peak oxygen uptake (VO2peak) across childhood, adolescence and young adulthood in Barth syndrome: Data from cross-sectional and longitudinal studies (2018)

In conclusion, VO2peak relative to body weight and fat-free mass demonstrates short- and long-term stability from childhood to young adulthood in BTHS with some variability among individuals.
Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 in Aerosol Suspensions (2020)

We aerosolized severe acute respiratory syndrome coronavirus 2 and determined that its dynamic aerosol efficiency surpassed those of severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome. Although we performed experiment only once across several laboratories, our findings suggest retained infectivity and virion integrity for up to 16 hours in respirable-sized aerosols.
Supp Data from Tumor Evolution Inferred by Patterns of microRNA Expression through the Course of Disease, Therapy, and Recurrence in Breast Cancer (2023)

&lt;p&gt;Supplementary methods Figure S1: The types of samples that were collected for each patient from cohort 2 (recurrence-freee patients). Figure S2: qPCR validations for Nanostring expression measurements. Figure S3: P1 miRNAs expression levels pre- and post-treatment versus normal breast tissue. Figure S4: miR-10b* expression levels. Figure S5: P1 miRNAs and their cell cycle predicted targets BUB1B and CDC25A. Figure S6: P1 scores and Ki67 levels by immunostaining. Figure S7: P1 scores in the METABRIC dataset. Figure S8: P2 miRNAs differentiate between recurrence and recurrence-free patients. Figure S9: P1 and P2 expression levels in ER-positive patients alone. Figure S10: Enrichment of EMT-induced genes in the correlated genes to P5 miRNAs. Figure S11: P5 and P6 miRNAs expression levels at post-treatment lymph nodes approach the levels at recurrence. Figure S12: Effects of the thresholds on the number of miRNAs that were classified to a pattern. Table S1: Miller and Payne grades and RCB classes Table S2: miRNAs' potential role in breast cancer from the literature Table S3: Pathway analysis; shared correlatred pathways across each pattern Table S4: Target genes for P1 miRNAs&lt;/p&gt;