gebhart/patrepeval huggingface dataset:
Microwave synthesized TiP2O7 assisted by carbon‐coating as anode material for aqueous rechargeable lithium‐ion batteries (2020)

Abstract TiP 2 O 7 and carbon‐coated TiP 2 O 7 were successfully synthesized via a rapid microwave method and were electrochemically tested in 1 M Li 2 SO 4 aqueous electrolyte. Physical properties were characterized through X‐ray diffraction, thermal gravimetric analysis, scanning electron microscopy, and transmission electron microscopy. The relationship between processing parameters (graphite concentration, ball mill duration, microwave energy input, heating duration) and the final products' electrochemical performance was studied. Full cell tests with LiMn 2 O 4 cathode materials were also tested to obtain cycling stability and rate performance results. The highest specific capacity of C‐TiP 2 O 7 was 109 mAh g ‐1 (90.1% of the theoretical capacity) from the cyclic voltammetry test with the scan rate of 0.3 mV s ‐1 . After 200 cycles under the rate of 0.5C, the C‐TiP 2 O 7 ’s capacity still maintained 92% of the initial capacity. These results suggested that the rapid microwave synthesis method is a promising process to synthesis the electrode materials with excellent electrochemical performances.
The ras Oncoprotein and M-Phase Activity (1991)

The endogenous mos proto-oncogene product (Mos) is required for meiotic maturation. In Xenopus oocytes, the ras oncogene product (Ras) can induce meiotic maturation and high levels of M-phase--promoting factor (MPF) independent of endogenous Mos, indicating that a parallel pathway to metaphase exists. In addition, Ras, like Mos and cytostatic factor, can arrest Xenopus embryonic cell cleavage in mitosis and maintain high levels of MPF. Thus, in the Xenopus oocyte and embryo systems Ras functions in the M phase of the cell cycle. The embryonic cleavage arrest assay is a rapid and sensitive test for Ras function.
Antimicrobial Activity in the Gasphase with Hypochloric Acid (2021)

Background:The study investigated if the disinfecting potential of Hypochlorous acid (HOCl) in suspensions are transferrable to in-air cleaning applications and to what extent aerosolized HOCl solutions can deactivate indoor microbial contaminations in-air at or below legal limits. Material and Method: For the liquid disinfection we used a standard suspension disinfection test protocol. For the in-air tests we conducted several experiments where aerosolized bacterial suspensions were injected into lab chambers preloaded with different HOCl gas concentrations. Results:In suspension experiments we found sufficient efficacies for all studied organisms at minimum concentrations of 200 ppm HOCl. The in-air measurement set-up allows to follow microbe deactivation by HOCl interaction. The deactivation rate increases with the HOCl concentration, and the values are highest for Gram-negative bacteria. Conclusion:We confirmed our hypothesis of the high disinfecting power of HOCl in-air at safe levels for populated indoor places. The investigated bacteria provide a model system for infectious particles, including enveloped viruses (to which Coronavirus belongs). These early results suggest that HOCl should be further evaluated as an air-cleaning method which may complement established concepts.
An Adaptive Probabilistic Trust Model and its Evaluation (Short Paper) (2008)

In open settings, the participants are autonomous and there is no central authority to ensure the felicity of their interactions. When agentsinteractinsuchsettings, eachreliesuponbeingabletomodel the trustworthiness of the agents with whom it interacts. Fundamentally, such models must consider the past behavior of the other parties in order to predict their future behavior. Further, it is sensible for the agents to share information via referrals to trustworthy agents. Much progress has recently been made on probabilistic trust models including those that support the aggregation of information from multiple sources. However, current models do not support trust updates, leaving updates to be handled in an ad hoc manner. This paper proposes a trust representation that combines probabilitiesandcertainty(definedasafunctionofaprobability-certainty density function). Further, it offers a trust update mechanism to estimate the trustworthiness of referrers. This paper describes a testbed that goes beyond existing testbeds to enable the evaluation of a composite probability-certainty model. It then evaluates the proposed trust model showing that the trust model can (a) estimate trustworthiness of damping and capricious agents correctly, (b) update trust values of referrers accurately, and (c) resolve the conflicts in referral networks by certainty discounting.
Direct Observation of Ultrafast Excited State Dynamics in Condensed Phase Photochemistry and Photobiology (2000)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text R. J. Sension, N. A. Anderson, J. J. Shiang, and A. G. Cole, "Direct Observation of Ultrafast Excited State Dynamics in Condensed Phase Photochemistry and Photobiology," in Ultrafast Phenomena, T. Li, ed., Vol. 43 of OSA Trends in Optics and Photonics (Optica Publishing Group, 2000), paper ME6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
MOD Buffer/YBCO Approach to Fabricate Low-Cost Second Generation HTS Wires (2007)

The metal organic deposition (MOD) of buffer layers on RABiTS substrates is considered a potential, low-cost approach to manufacturing high performance Second Generation (2G) high temperature superconducting (HTS) wires. The typical architecture used by American Superconductor in their 2G HTS wire consists of a Ni-W (5 at.%) substrate with a reactively sputtered Y <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> seed layer, YSZ barrier layer and a CeO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> cap layer. This architecture supports critical currents of over 300 A/cm-width (77 K, self-field) with 0.8 mum YBCO films deposited by the TFA-MOD process. The main challenge in the development of the MOD buffers is to match or exceed the performance of the standard vacuum deposited buffer architecture. We have recently shown that the texture and properties of MOD - La <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Zr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">gamma</sub> (LZO) barrier layers can be improved by inserting a thin sputtered Y <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> seed layer and prepared MOD deposited LZO layers followed by MOD or RF sputtered CeO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> cap layers that support MOD-YBCO films with Ic's of 200 and 255 A/cm-width, respectively. Detailed X-ray and microstructural characterizations indicated that MOD - CeO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> cap reacted completely with MOD YBCO to form BaCeOs. However, sputtered CeO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> cap/MOD YBCO interface remains clean. By further optimizing the coating conditions and reducing the heat-treatment temperatures, we have demonstrated an Ic of 336 A/cm with improved LZO layers and sputtered CeO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> cap and exceeded the performance of that of standard vacuum deposited buffers.
Sensitive and quantitative detection of MHC-I displayed neoepitopes using a semi-automated workflow and TOMAHAQ mass spectrometry (2020)

Abstract Advances in several key technologies, including MHC peptidomics, has helped fuel our understanding of basic immune regulatory mechanisms and identify T cell receptor targets for the development of immunotherapeutics. Isolating and accurately quantifying MHC-bound peptides from cells and tissues enables characterization of dynamic changes in the ligandome due to cellular perturbations. This multi-step analytical process remains challenging, and throughput and reproducibility are paramount for rapidly characterizing multiple conditions in parallel. Here, we describe a robust and quantitative method whereby peptides derived from MHC-I complexes from a variety of cell lines, including challenging adherent lines, can be enriched in a semi-automated fashion on reusable, dry-storage, customized antibody cartridges. TOMAHAQ, a targeted mass spectrometry technique that combines sample multiplexing and high sensitivity, was employed to characterize neoepitopes displayed on MHC-I by tumor cells and to quantitatively assess the influence of neoantigen expression and induced degradation on neoepitope presentation.
Continuous countercurrent chromatographic twin‐column purification of oligonucleotides: The role of the displacement effect (2022)

Oligonucleotides (ONs) are breaking through in the biopharmaceutical industry as a promising class of biotherapeutics. The main success of these molecules is due to their peculiar way of acting in the cellular process, regulating the gene expression and hence influencing the protein synthesis at a pretranslational level. Although the Food and Drug Administration (FDA) already approved a few ON-based therapeutics, their production cost strongly limits large-scale manufacturing: a situation that can be alleviated through process intensification. In this study, we address this problem by developing an efficient and continuous chromatographic purification process for ONs. In particular, we considered the chromatographic purification of an ON crude prepared by chemical synthesis using anion exchange resins. We demonstrate that in this system the competitive adsorption of the various species on the same sites of the resin leads to the displacement of the more weakly adsorbing species by the more strongly adsorbing ones. This phenomenon affects the behavior of the chromatographic units and it has been investigated in detail. Then, we developed a continuous countercurrent solvent gradient purification (MCSGP) process, which can significantly improve the productivity and buffer consumption compared to a classical single-column, batch chromatographic process.
Aerospace Plane Ascending Trajectories with Heat Consideration (1996)

This is a study of performance and control for transatmospheric (TAV) aerospace planes, that use air-breathing propulsion. The study is structured in two parts and considers the heat load near the stagnation point. The first part is analytical and consists of two cases, it seeks closed form solutions for the non-linear feedback controls (aerodynamic and thrust), which are necessary to transfer the (TAV) from one specified state to another specified state, while satisfying pairs of equality constraints (that is, Case I: constant acceleration with constant dynamic pressure and Case II: constant rate of climb with constant dynamic pressure). This leads to closed form solutions for the controls in feedback form and also for the heat rate and load. The analytical approach gives a reasonable approximation of the general ascent trajectory to orbit, where the two cases can be used in combination with different constant values of the constraints in different levels of the hypersonic trajectory. The analytical results were a useful guide in the numerical studies. The second part describes numerical simulation and optimization. The control laws, which minimize the heat load, are found in feedback form. A numerical example is worked out for illustration. The trajectory corridor and, in general, all the constraints are satisfied for heat load ≤ 350 kJ/cm 2 using feasible controls.
Polarization controlled directional propagation of Bloch surface wave (2017)

Bloch surface waves (BSWs) are recently developing alternative to surface plasmon polaritons (SPPs). Due to dramatically enhanced propagation distance and strong field confinement these surface states can be successfully used in on-chip all-optical integrated devices of increased complexity. In this work we propose a highly miniaturized grating based BSW coupler which is gathering launching and directional switching functionalities in a single element. This device allows to control with polarization the propagation direction of Bloch surface waves at subwavelength scale, thus impacting a large panel of domains such as optical circuitry, function design, quantum optics, etc.
Lungkine, a Novel CXC Chemokine, Specifically Expressed by Lung Bronchoepithelial Cells (1999)

We describe a novel mouse CXC chemokine that is selectively expressed in lung epithelial cells and up-regulated in various lung inflammation models. Although this chemokine clusters with other ELR-CXC chemokines, none of them can confidently be assigned to be its human homologue based on sequence identity. In addition, the highly restricted mRNA tissue distribution of this chemokine differentiates it from all previously described chemokines: Lungkine could not be detected in any of the 70 cDNA libraries analyzed corresponding to specific murine cell populations and tissues. High levels of Lungkine mRNA were specifically detected in the lung and at lower levels in fetal lung tissue by Northern blot and in situ hybridization, suggesting a potential role for this chemokine during lung development. Moreover, Lungkine protein is secreted into the airway spaces and induces the in vitro and in vivo migration of neutrophils, suggesting that it is involved in lung-specific neutrophil trafficking. Using fluorescent in situ hybridization, we show that Lungkine maps to mouse chromosome 5.
Dual Probe Sensors Using Atomically Precise Noble Metal Clusters (2017)

[Image: see text] This article adds a new direction to the functional capability of protein-protected atomically precise gold clusters as sensors. Counting on the extensively researched intense luminescence of these clusters and considering the electron donating nature of select amino acids, we introduce a dual probe sensor capable of sensing changes in luminescence and conductivity, utilizing bovine serum albumin-protected atomically precise gold clusters hosted on nanofibers. To this end, we have also developed a hybrid nanofiber with a conducting core with a porous dielectric shell. We show that clusters in combination with nanofibers offer a highly selective and sensitive platform for the detection of trace quantities of trinitrotoluene, both in solution and in the vapor phase. In the solution phase, trinitrotoluene (TNT) can be detected down to 1 ppt at room temperature, whereas in vapor phase, 4.8 × 10(9) molecules of TNT can be sensed using a 1 mm fiber. Although the development in electrospinning techniques for fabricating nanofibers as sensors is quite substantial, a hybrid fiber with the dual properties of conductivity and luminescence has not been reported yet.
Dexamethasone Normalizes Brain Tumor Hemodynamics as Indicated by Dynamic Susceptibility Contrast MRI Perfusion Parameters (2005)

The purpose of this study is to demonstrate the utility of dynamic susceptibility contrast (DSC) MRI-derived perfusion parameters to characterize the hemodynamic effects of dexamethasone in a 9L gliosarcoma tumor model. Twenty-four rats underwent intracerebral inoculation with 9L tumor cells. Fifteen were treated with a total of 3mg/kg of dexamethasone on days 10-14 post-inoculation, while the remaining 9 rats served as controls. Fourteen days post-inoculation, MRI images, sensitive to total and micro-vascular cerebral blood flow (CBF), mean transit time (MTT), and intravoxel transit time distributions (TTD)s were obtained using a simultaneous gradient-echo(GE)/spin-echo(SE) DSC-MRI method. Dexamethasone-treated animals had a microvascular (SE) tumor CBF that was 45.9% higher (p = 0.0008) and a MTT that was 47.8% lower (p = 0.0005) than untreated animals. With treatment, there was a non-significant 91.3% increase in total (GE) vascular CBF (p = 0.35), and a significant decrease in MTT (49.1%, p = 0.02). The total vascular and microvascular TTDs from the treated tumors were similar to normal brain, unlike the TTDs in the untreated tumors. These findings demonstrate that DSC-MRI perfusion methods can be used to non-invasively detect the morphological and functional changes in tumor vasculature that occur in response to dexamethasone treatment.
Tracheal and bronchial granular cell tumours: A French retrospective study on 30 patients (2015)

<b>Introduction:</b> Granular cell tumours (GCT, or Abrikossoff tumours) are rare, usually benign tumours, arising from Schwann cells. Tracheal and/or bronchial involvement has been rarely described. The objective of this study is to describe population characteristics, clinical and bronchoscopic data, as well as therapeutic options for bronchial or tracheal GCTs. <b>Methods:</b> All of the French cases of tracheal or bronchial GCT were included, and data were retrospectively collected. <b>Results:</b> Thirty-five cases of proximal GCT, including 10 tracheal and 25 bronchial lesions, in 30 patients were reported between 1994 and 2013. GCTs were more frequent in males (sex ratio = 1,5), the age at diagnosis was 48 y. (13–76 y.). Synchronous lung carcinoma was found in 3 patients (10%). Tumour diameter was higher in tracheal (23,8 mm) <i>vs</i> bronchial (9,8 mm) GCTs. The macroscopic aspect during bronchoscopy was usually a white, well-limited lesion without hypervascularization. Treatment information was not available for 7 patients. Seven other patients did not receive any treatment. Local treatment was performed in 12 patients, usually by mechanic resection combined with thermocoagulation. Complete endoscopic resection was obtained in 9/12 patients (75%). Surgery was performed in 4 patients (2 for suspected lung cancer ; one because of tracheal stenosis ; unavailable surgery indication for one patient), with complete resection. There was no recurrence of GCT during a median follow-up of 19 months. <b>Conclusion:</b> This is the largest series on proximal GCTs, which suggests that, when resection is needed, endoscopic treatment enables complete resection in most of the cases and appears as a reasonable first line treatment.
A Potent Oligosaccharyl Transferase Inhibitor That Crosses the Intracellular Endoplasmic Reticulum Membrane (1999)

Recent work has resulted in the development of potent inhibitors of oligosaccharyl transferase (OT), the enzyme that catalyzes the cotranslational glycosylation of asparagine [Hendrickson, T. L., Spencer, J. R., Kato, M., and Imperiali, B. (1996) J. Am. Chem. Soc. 118, 7636-7637; Kellenberger, C., Hendrickson, T. L., and Imperiali, B. (1997) Biochemistry 36, 12554-12559]. However, no specific OT inhibitors that function in the cellular environment have yet been reported. The peptide cyclo(hex-Amb-Cys)-Thr-Val-Thr-Nph-NH2 was previously shown to exhibit nanomolar inhibition (Ki = 37 nM) through slow tight binding kinetics [Hendrickson, T. L., Spencer, J. R., Kato, M., and Imperiali, B. (1996) J. Am. Chem. Soc. 118, 7636-7637]. Included herein is the redesign of this prototype inhibitor for achieving both passive and active translocation into model membrane systems representing the endoplasmic reticulum (ER). The strategy for passive transport involved the incorporation of a membrane permeable import function previously shown to carry various peptides across the outer as well as the interior cellular membranes [Rojas, M., Donahue, J. P., Tan, Z., and Lin, Y.-Z. (1998) Nat. Biotechnol. 16, 370-375]. Assessment of function in intact ER membranes revealed that the inhibitor targeted toward passive diffusion demonstrated concentration-dependent inhibition of two different glycosylation substrates. Thus, this modified inhibitor achieved potent inhibition of glycosylation after being successfully transported through the ER membrane. In the active translocation approach, the lead OT inhibitor and a corresponding substrate were redesigned to include features recognized by the transporter associated with antigen processing (TAP). This protein translocates peptides into the lumen of the ER [Heemels, M.-T., Schumacher, T. N. M., Wonigeit, K., and Ploegh, H. L. (1993) Science 262, 2059-2063]. However, although acceptance of the cyclized substrate by the TAP receptor was demonstrated via efficient transport and glycosylation, the modified inhibitor was not translocated by TAP machinery, and therefore, active translocation was achieved for the modified substrate only. Both of these ER transport methods afforded redesigned OT inhibitors that retained their inhibitor properties in vitro, regardless of the extensions to the carboxy-terminus of the root inhibitor. The above family of redesigned inhibitors provides a template for generating a transcellular pathway and represents the first step toward OT inhibition in intact cells.
Gas sorption and transport properties of bisphenol‐I‐polycarbonate (1994)

Abstract Gas sorption and transport characterization of a new polymer in the polycarbonate family, based on the bisphenol of 3,3,5‐trimethylcyclohexane‐1‐one (BPI) is reported at 35°C. By comparison with properties of other known polycarbonates, the effects of inhibition of both packing and segmental motion due to the introduction of the bulky substituent in the backbone are elucidated. The T g of the material was measured with differential scanning calorimeter (DSC) and was found to be unusually high for a polycarbonate (233°C). This indicates a successful inhibition of the large‐scale segmental mobility of the polymer. Variable 13 C NMR analysis indicated that rotation of one phenylene ring has an unusually high (ca. 10 kcal) energy barrier, whereas the other phenylene ring has a more typical rotation profile (barrier &lt; 3 kcal). The density was measured and found to be low (1.107 g/cm 3 ), indicating a high fractional free volume (FFV) for the polymer. Consistent with expectations, the introduction of the bulky‐substituted cyclohexane group gave high permeabilities for the various gases tested (N 2 , O 2 , He, CH 4 , CO 2 ) compared to most standard polycarbonates. On the other hand, the permselectivities were typical for standard polycarbonates. The solubility coefficients of all gases were rather high, as expected for a polymer with such an open structure. © 1994 John Wiley &amp; Sons, Inc.