gebhart/patrepeval huggingface dataset:
Initial Timing Acquisition Algorithm for Terrestrial Cloud Transmission Systems (2014)

본 논문에서는 지상파 클라우드 방송 시스템 (cloud transmission system)을 위한 수신기 초기 타이밍 획득 알고리즘을 제안한다. 제안된 방식은 프리앰블 심벌 내의 다양한 반복패턴에 대한 자기상관 값들을 결합하여 동일채널간섭이 존재하는 클라우드 방송 시스템에서 타이밍 메트릭의 신뢰성을 향상시킬 수 있다. 전산 실험 결과는 제안한 방식이 클라우드 방송 시스템 환경에서 타이밍 메트릭의 신뢰성을 향상시킴을 보여준다. In this paper, we propose an initial timing acquisition algorithm for terrestrial cloud transmission (CTxn) systems. By combining auto-correlations of several repetition patterns within preamble symbols, the proposed scheme can improve the reliability of the timing metric for CTxn system with co-channel interferences. Simulation results show that the proposed scheme improves the reliability of the timing metric for terrestrial CTxn systems.
Frequential identification of a Proton Exchange Membrane Fuel Cell (PEMFC) fractional order model (2014)

International audience
ChemInform Abstract: Synthesis of 3‐Aminomethyl‐3‐fluoropiperidines. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Real-Time Simulation Technologies: Principles, Methodologies, and Applications (2012)

Parallel and distributed simulation (PADS) emerged in the early 1980s, and over the past three decades, PADS systems have matured into vital technologies, particularly for military applications. This chapter provides a basic overview of one specific PADS application area: distributed real-time simulation-based training (SBT). The chapter opens with a brief description of distributed real-time SBT and its development. It then lists the recurrent challenges faced by such systems with respect to instructional best practices, technology, and use.
The Epstein-Barr Virus EBNA-LP Protein Preferentially Coactivates EBNA2-Mediated Stimulation of Latent Membrane Proteins Expressed from the Viral Divergent Promoter (2005)

The mechanistic contribution of the Epstein-Barr virus (EBV) EBNA-LP protein to B-cell immortalization remains an enigma. However, previous studies have indicated that EBNA-LP may contribute to immortalization by enhancing EBNA2-mediated transcriptional activation of the LMP-1 gene. To gain further insight into the potential role EBNA-LP has in EBV-mediated B-cell immortalization, we asked whether it is a global or gene-specific coactivator of EBNA2 and whether coactivation requires interaction between these proteins. In type I Burkitt's lymphoma cells, we found that EBNA-LP strongly coactivated EBNA2 stimulation of LMP-1 and LMP2B RNAs, which are expressed from the viral divergent promoter. Surprisingly, the viral LMP2A gene and cellular CD21 and Hes-1 genes were induced by EBNA2 but showed no further induction after EBNA-LP coexpression. We also found that EBNA-LP did not stably interact with EBNA2 in coimmunoprecipitation assays, even though the conditions were adequate to observe specific interactions between EBNA2 and its cellular cofactor, CBF1. Colocalization between EBNA2 and EBNA-LP was not detectable in EBV-transformed cell lines or transfected type I Burkitt's cells. Finally, no significant interactions between EBNA2 and EBNA-LP were found with mammalian two-hybrid assays. From this data, we conclude that EBNA-LP is not a global coactivator of EBNA2 targets, but it preferentially coactivates EBNA2 stimulation of the viral divergent promoter. While this may require specific transient interactions between these proteins that only occur in the context of the divergent promoter, our data strongly suggest that EBNA-LP also cooperates with EBNA2 through mechanisms that do not require direct or indirect complex formation between these proteins.
Remote scientific visualization of progressive 3D meshes with X3D (2010)

International audience
Passive microring-resonator-coupled lasers (2001)

In this letter, a passive microring-resonator-coupled semiconductor laser structure is proposed. The weakly coupled high-Q microring resonator provides a strong mode-selection filter and could considerably extend the effective cavity length of a conventional Fabry–Perot laser. The side-mode suppression ratio, the linewidth and the frequency chirp of this laser are dramatically improved comparing to distributed feedback and distributed Bragg reflector lasers.
Basin‐scale tomography: A new tool for studying weather and climate (1991)

We present the first experimental results demonstrating the use of acoustic tomography to observe the large‐scale (&gt;500 km) temperature fluctuations in ocean basins. Use of the tomographic technique, as presented here, will eventually lead to a better understanding of weather, climate, ocean circulation, and the distributions of marine organisms. From June to September 1987, tomographic signals were transmitted between four sources and nine receivers over a 3000 by 4000 km region (the basin‐scale) in the northeast Pacific. This paper discusses five issues related to transmissions across one 3000 km section. First, basin‐scale tomography is feasible because multipaths are stable in the presence of ocean fluctuations and the multipaths can be understood with ray theory (and its extensions). Second, the tomography problem can be initiated from climatological estimates. It is unnecessary to initiate with conventional measurements during the experiment (a prohibitively expensive proposition). Third, a description of the tomographic reconstruction procedure (Kalman filtering) is presented. The filter imposes temporal and spatial constraints on the solution for the thermal field. Fourth, the sensitivity of the estimated thermal field is examined with respect to variations of the constraints. Thermal maps are not very sensitive to variations of the constraints. Fifth, tomography is used to observe significant changes from month‐to‐month in the large‐scale thermal field in the ocean, including the seasonal thermocline where week‐to‐week resolution can be obtained. In contrast, available point measurements appear to be insufficient for observing monthly changes in the large‐scale thermal field in the ocean. These acoustic measures of weather and climate in the ocean cannot be verified with other data (e.g., satellites, point measurements) and thus provide an orthogonal perspective by which weather and climate may be observed and understood.
Analysis of ASB10 variants in open angle glaucoma (2012)

Glaucoma is a common cause of visual disability and affects ∼1.6% of individuals over 40 years of age ( 1). Non-synonymous coding sequence variations in the ankyrin repeat and SOCS box containing gene 10 (ASB10) were recently associated with 6.0% of cases of primary open angle glaucoma (POAG) in patients from Oregon and Germany. We tested a cohort of POAG patients (n= 158) and normal control subjects (n= 82), both from Iowa, for ASB10 mutations. Our study had 80% power to detect a 4.9% mutation frequency in POAG patients. A total of 11 non-synonymous coding sequence mutations were detected in the cohort, but no association with POAG was detected when analyzed individually or as a group (P > 0.05). Furthermore, a survey of the National Heart, Lung, and Blood Institute's (NHLBI's) Exome Sequencing Project revealed that non-synonymous ASB10 mutations are present in the general population at a far higher frequency than the prevalence of POAG. These data suggest that non-synonymous mutations in ASB10 do not cause Mendelian forms of POAG.
Safety and Pharmacokinetics/Pharmacodynamics of the First-in-Class Dual Action HER3/EGFR Antibody MEHD7945A in Locally Advanced or Metastatic Epithelial Tumors (2015)

MEHD7945A was well-tolerated as single agent with evidence of tumor pharmacodynamic modulation and antitumor activity in SCCHN. Phase II studies were initiated with flat (nonweight-based) dosing at 1,100 mg q2w in SCCHN and colorectal cancer.
Recombinant Human Erythropoietins and Cancer Patients: Updated Meta-Analysis of 57 Studies Including 9353 Patients (2006)

This is an updated systematic review of 57 trials and 9353 cancer patients from articles, abstracts, and reports published between January 1, 1985, and April 30, 2005, on the effects of epoetin alfa and beta (i.e., epoetin) and darbepoetin alfa (i.e., darbepoetin). We included randomized controlled trials comparing epoetin or darbepoetin plus red blood cell transfusion with red blood cell transfusion alone for prophylaxis or treatment of anemia in cancer patients with or without concurrent antineoplastic therapy. The Cochrane Library, MEDLINE, EMBASE, and conference proceedings were searched. Effect estimates and 95% confidence intervals (CIs) were calculated with fixed-effects models. Treatment with epoetin or darbepoetin statistically significantly reduced the risk for red blood cell transfusions (relative risk [RR] = 0.64, 95% CI = 0.60 to 0.68; 42 trials and 6510 patients) and improved hematologic response (RR = 3.43, 95% CI = 3.07 to 3.84; 22 trials and 4307 patients). Treatment with epoetin or darbepoetin increased the risk of thrombo-embolic events (RR = 1.67, 95% CI = 1.35 to 2.06; 35 trials and 6769 patients). Uncertainties remain as to whether and how epoetin or darbepoetin affects overall survival (hazard ratio = 1.08, 95% CI = 0.99 to 1.18; 42 trials and 8167 patients). Caution is advised when using epoetin or darbepoetin in combination with thrombogenic chemotherapeutic agents or for cancer patients who are at high risk for thrombo-embolic events.
To eat, or not to eat, that is the question: Neural stem cells escape phagocytosis in autism with macrocephaly (2021)

Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder that is thought to emerge very early in development. Cerebral overgrowth, which is clinically referred to as macrocephaly, is frequently observed in children with ASD, and brain imaging studies have reported increases in both gray- and white-matter volume (1⇓⇓⇓⇓–6). Children with these early signs of brain enlargement have been shown to be part of an ASD group with high probability of receiving a diagnosis (3, 5⇓–7). The presence of additional numbers of neurons and increased cortical thickness in the prefrontal cortex of the postmortem brain from ASD patients complement these clinical observations (8). Copy number variation (CNV) in the 16p region of chromosome 16 has been linked to ASD and can manifest in opposing head sizes. Deletion of 16p11.2, which is probably one of the most well-known CNVs linked to ASD, generally leads to macrocephaly, whereas duplications in this region have been associated with smaller head sizes (9⇓⇓–12). The cellular mechanisms that underlie these opposing phenotypes remain unknown. Considering that live human brain tissues are inaccessible to study the cellular mechanisms that are contributing to these phenomena, the advent of induced pluripotent stem cell (iPSC) technologies has propelled research on this front as it allows researchers to generate any type of cell from human skin or blood. In PNAS, Li et al. take advantage of such an approach to explore the cellular mechanisms that could be involved in gray- and white-matter enlargement related to ASD (13). Here, iPSCs from a cohort of 16p11.2 deletion and duplication carriers were used to derive specific cellular models of the developing brain, in particular neural stem cells (NPCs), the precursors that will continue to form the cells of the gray … [↵][1]1To whom correspondence may be addressed. Email: sschafer{at}salk.edu or gage{at}salk.edu. [1]: #xref-corresp-1-1
In-service monitoring of PMD induced optical signal degradation using SOP vector trajectory on the Poincare sphere (2009)

The performance of signal monitoring was studied to estimate signal degradation by processing data obtained from SOP measurement. Good correlation between measured Q-value and estimation from SOP data was observed under the existence of SOPMD.
Joint common mode voltage and differential offset voltage control scheme in a low-IF receiver (2004)

Direct RF sampling has recently been presented (K. Muhammad et al., Proc. IEEE Solid-State Circ. Conf, sec. 15.1, pp. 268-269, 527, 2004; K. Muhammad and R.B. Staszewski, Proc. IEEE Intl. Symp. on Circ. and Sys., sec. ASP-L29.5, 2004) in which an input RF signal is converted to current waveform, down-converted and integrated on a sampling capacitor. A rotating capacitor shares this charge with the sampling capacitor and transfers it to a subsequent discrete time switched-capacitor filter stage. In this paper, we present a mixed-signal approach for controlling the common mode voltage as well as injecting differential charge to compensate for the DC-offsets. This approach has been validated and incorporated in a commercial Bluetooth receiver IC realized in a digital 130 nm CMOS technology that meets or exceeds performance of other conventional Bluetooth radio architectures.
Strength Development of Low Heat Cement Mortar by Carbonation Curing (1999)

The strength development caused by carbonating low heat cement mortar was compared with those of ordinary portland cement and blast-furnace slag cement mortars. The variation of the strength development of low heat cement mortar under various curing conditions was investigated. The low heat cement and blast-furnace slag cement mortars were easily carbonated than the ordinary portland cement mortar. The strength of the low heat cement mortar treated by the carbonation was higher than that of the blast-furnace slag cement mortar treated by it. However, the strength developments of these types of mortar largely varied according to the starting time and period of the carbonation reaction. The strength of mortar was measured and the distribution of pore in and the specific surface area of the hardened cement paste were studied and elucidated that the total pore volume in the hardened low heat cement was remarkably reduced and the specific surface area of it was increased by the carbonation.
Power allocation for energy-constrained cognitive radios in the presence of an eavesdropper (2014)

Reliable and agile spectrum sensing as well as secure communication are key requirements of a cognitive radio system. In this paper, secrecy throughput of a cognitive radio is maximized in order to determine the sensing threshold, the sensing time, and the transmission power. Constraints of the problem are defined as a lower-bound on the detection probability, an upper-bound on the average energy consumption per time-frame, and the maximum transmission power of the cognitive radio. We show that the problem can be solved by an on-off strategy where the cognitive radio only performs sensing and transmits data if the cognitive channel gain is greater than the average eavesdropper channel gain. The problem is then solved by a line-search over sensing time. Eventually, the secrecy throughput of the cognitive radio is evaluated employing the IEEE 802.15.4/Zig-Bee standard.
Viable Mice with Compound Mutations in the Wnt/Dvl Pathway Antagonists nkd1 and nkd2 (2007)

Gradients of Wnt/beta-catenin signaling coordinate development and physiological homeostasis in metazoan animals. Proper embryonic development of the fruit fly Drosophila melanogaster requires the Naked cuticle (Nkd) protein to attenuate a gradient of Wnt/beta-catenin signaling across each segmental anlage. Nkd inhibits Wnt signaling by binding the intracellular protein Dishevelled (Dsh). Mice and humans have two nkd homologs, nkd1 and nkd2, whose encoded proteins can bind Dsh homologs (the Dvl proteins) and inhibit Wnt signaling. To determine whether nkd genes are necessary for murine development, we replaced nkd exons that encode Dvl-binding sequences with IRES-lacZ/neomycin cassettes. Mutants homozygous for each nkd(lacZ) allele are viable with slightly reduced mean litter sizes. Surprisingly, double-knockout mice are viable, with subtle alterations in cranial bone morphology that are reminiscent of mutation in another Wnt/beta-catenin antagonist, axin2. Our data show that nkd function in the mouse is dispensable for embryonic development.
Latent Pathway Activation and Increased Pathway Capacity Enable Escherichia coli Adaptation to Loss of Key Metabolic Enzymes (2005)

The ability of biological systems to adapt to genetic and environmental perturbations is a fundamental but poorly understood process at the molecular level. By quantifying metabolic fluxes and global mRNA abundance, we investigated the genetic and metabolic mechanisms that underlie adaptive evolution of four metabolic gene deletion mutants of Escherichia coli (delta pgi, delta ppc, delta pta, and delta tpi) in parallel evolution experiments of each mutant. The initial response to the gene deletions was flux rerouting through local bypass reactions or normally latent pathways. The principal effect of evolution was improved capacity of already active pathways, whereas new flux distributions were not observed. Combinatorial changes in capacity and pathway activation, however, led to different intracellular flux states that enabled evolution in three of the four parallel cases tested. The molecular bases of the evolved phenotypes were then elucidated by global mRNA transcript analyses. Activation of latent pathways and flux changes in the tricarboxylic acid cycle were found to correlate well with molecular changes at the transcriptional level. Flux alterations in other central metabolic pathways, in contrast, were apparently not connected to changes in the transcriptional network. These results give new insight into the dynamics of the evolutionary process by demonstrating the flexibility of the metabolic network of E. coli to compensate for genetic perturbations and the utility of combining multiple high throughput data sets to differentiate between causal and noncausal mechanistic changes.
Non-invasive passive energy dissipation systems for the seismic design and retrofit of steel structures (2021)

A passive axial elasto-plastic device is introduced locally near beam-to-column joints of steel moment resisting frames to enhance the energy dissipating capacity during earthquakes. The geometry, stiffness and slip or yield load are chosen to maximize the energy dissipated during a monotonic push. A typical 6-story moment resisting frame is first retrofitted with haunch type connections, with no slipping allowed. The building is then retrofitted with the same geometric configuration of the haunch but with an increased stiffness. Finally a third retrofit strategy consisting of replacing the haunch with energy dissipating devices is implemented. Nonlinear time-history analyses where the fracture of welds is modeled with a strength degrading element are performed under different intensities of seismic ground motions. Results indicate that an increased haunch stiffness is more effective in protecting the weld fractures under large seismic loading. The energy dissipating haunch reduced significantly the response of the structure while still protecting the welded connections.
Aperture optimization for emission imaging:effect of a spatially varying background (1990)

A method for optimizing the aperture size in emission imaging is presented that takes into account limitations due to the Poisson nature of the detected radiation stream as well as the conspicuity limitation imposed by a spatially varying background. System assessment is based on the calculated performance of two model observers: the best linear observer, also called the Hotelling observer, and the nonprewhitening matched-filter observer. The tasks are the detection of a Gaussian signal and the discrimination of a single from a double Gaussian signal. When the background is specified, detection is optimized by enlarging the aperture; an inhomogeneous background results in an optimum aperture size matched naturally to the signal. The discrimination task has a finite optimum aperture for a flat background; a nonuniform background drives the optimum toward still-finer resolution.
ChemInform Abstract: Highly Regioselective Nickel‐Catalyzed Cross‐Coupling of N‐Tosylaziridines and Alkylzinc Reagents. (2015)

Abstract Procedures are evaluated which allow the reaction of aliphatic aziridine substrates with aliphatic organozinc reagents.
CDMP1/GDF5 Has Specific Processing Requirements That Restrict Its Action to Joint Surfaces (2006)

CDMP1/GDF5 has not demonstrated biological activity in Xenopus embryos when overexpressed by mRNA injection. We provide biological and biochemical evidence that to become active, the protein requires cleavage by two distinct proteolytic enzymes. We demonstrate a specific overlap in the expression patterns of CDMP1/GDF5 with the proteases required to release the mature peptide at the location of the future articular surface but not in the future joint space. Taken together, these observations provide a plausible mechanism for local action of CDMP1/GDF5 consistent with requirements imposed by current models of pattern formation in the developing limb.
A web of concepts (2009)

We make the case for developing a web of concepts by starting with the current view of web (comprised of hyperlinked pages, or documents, each seen as a bag of words), extracting concept-centric metadata, and stitching it together to create a semantically rich aggregate view of all the information available on the web for each concept instance. The goal of building and maintaining such a web of concepts presents many challenges, but also offers the promise of enabling many powerful applications, including novel search and information discovery paradigms. We present the goal, motivate it with example usage scenarios and some analysis of Yahoo! logs, and discuss the challenges in building and leveraging such a web of concepts. We place this ambitious research agenda in the context of the state of the art in the literature, and describe various ongoing efforts at Yahoo! Research that are related.
Slow search (2014)

Seeking to enrich the search experience by allowing for extra time and alternate resources.
Limitations of the Severe Combined Immunodeficiency (SCID) Mouse Model for Study of Human B‐Cell Responses (1995)

Mice lacking functional T and B lymphocytes offer an in vivo animal model for the study of human immune functions. We have attempted to optimize the reconstitution of severe combined immunodeficiency (SCID) mice with human peripheral blood lymphocytes (PBL) using radiation, anti-asialo GM1 antibody or cyclophosphamide (Cy) treatment of the mice and in vitro stimulation of human PBL with interleukin (IL)-2 prior to their transfer to the mice. Total human IgG and tetanus-toxoid (TT)-specific human IgG responses of the mice were used as parameters of successful reconstitution. Treatment of the mice with anti-asialo GM1 antibody significantly enhanced total human IgG levels, but not TT-specific antibody responses, whereas irradiation or Cy treatment of the mice had no effect on human antibody production. In vitro treatment of human PBL with IL-2 prior to engraftment significantly decreased total human IgG responses of human PBL-grafted SCID mice. The immune responses of individual mice within a group were highly variable, which constitutes a major disadvantage of this model.