gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Tertiary Amine‐Promoted Enone Aziridination: Investigations into Factors Influencing Enantioselective Induction. (2014)

Abstract Upon several tested tertiary amines quinine shows to be the best promoter for the asymmetric aziridination of α,β‐unsaturated ketones.
Hemophagocytic lymphohistiocytosis and hemozoin deposition in bone marrow macrophages in falciparum malaria (2022)

The authors declare no conflict of interest.
High-resolution MR imaging of the wrist and eye with short TR, short TE, and partial-echo acquisition. (1992)

High-resolution spin-echo and two- and three-dimensional gradient-recalled acquisition in the steady state (GRASS) and spoiled GRASS images of the wrist and eye were obtained with a whole-body magnetic resonance imager by using trapezoidal phase-encoding gradient waveforms and by lowering receiver bandwidth to +/- 8 kHz, which results in a minimum field of view (FOV) of 4 cm and pixel resolution of 156 microns for a 256 x 256 matrix. Short echo times were achieved by using partial-echo acquisition. Poor signal-to-noise ratio resulting from smaller voxel sizes was overcome by using prototype receive-only eye and wrist coils. Images were obtained in reduced time and were superior to those obtained in studies performed with an 8-12-cm FOV and commercially available coils.
An Efficient Limited Feedback for Multi-panel based 2D Antenna Array (2018)

In this paper, a multi-component codebook structure is proposed for a channel state information (CSI) feedback to achieve an optimized beamforming gain with a limited feedback overhead when a base station (BS) is equipped with a multi-panel based 2D antenna array, where each antenna panel is a uniform rectangular array (URA). The proposed multi-component code-book structure is extended from a codebook designed for a single-panel based 2D antenna array by introducing a component pre-coder which is used to co-phase precoders across the panels. System level simulation results show that introduction of the component precoders for co-phasing of multiple panels can provide significant user packet throughput performance gain with a marginal increase in feedback overhead.
Answering Science Exam Questions Using Query Reformulation with Background Knowledge (2019)

Open-domain question answering (QA) is an important problem in AI and NLP that is emerging as a bellwether for progress on the generalizability of AI methods and techniques. Much of the progress in open-domain QA systems has been realized through advances in information retrieval methods and corpus construction. In this paper, we focus on the recently introduced ARC Challenge dataset, which contains 2,590 multiple choice questions authored for grade-school science exams. These questions are selected to be the most challenging for current QA systems, and current state of the art performance is only slightly better than random chance. We present a system that reformulates a given question into queries that are used to retrieve supporting text from a large corpus of science-related text. Our rewriter is able to incorporate background knowledge from ConceptNet and -- in tandem with a generic textual entailment system trained on SciTail that identifies support in the retrieved results -- outperforms several strong baselines on the end-to-end QA task despite only being trained to identify essential terms in the original source question. We use a generalizable decision methodology over the retrieved evidence and answer candidates to select the best answer. By combining query reformulation, background knowledge, and textual entailment our system is able to outperform several strong baselines on the ARC dataset.
Two purified factors bind to the same sequence in the enhancer of mouse MHC class I genes: one of them is a positive regulator induced upon differentiation of teratocarcinoma cells (1989)

The MHC class I murine and beta-2-microglobulin genes are silent in embryonal carcinoma (EC) cells but are induced upon differentiation of these cells. We have previously shown that enhancer-like sequences located in the promoter of the H-2Kb gene are non-functional in F9 and PCC3 cells. We have previously purified a 48 kd protein (KBF1) from a mouse T cell line which binds to a palindromic sequence located in this enhancer and to a similar sequence in the promoter of the beta-2-microglobulin gene. We describe here the purification of a second protein (KBF2, 58 kd) which also binds to this sequence. While both activities are present in differentiated cells, KBF1 binding activity is absent in undifferentiated EC cells, where the palindromic sequence shows no enhancer activity. Upon differentiation, KBF1 binding activity is induced and the palindromic sequence becomes active as an enhancer. Thus, the absence of KBF1 activity in undifferentiated EC cells is at least in part responsible for the lack of expression of H-2 class I and beta-2-microglobulin genes in these cells and suggests that KBF1 activity is regulated during differentiation.
Monitoring microseismic fracture development to optimize stimulation and production in aging fields (2005)

The increasing worldwide demand for energy motivates the oil and gas industry to develop reservoirs that are continually more difficult to produce. These difficulties are due to the reservoir characters (tight gas sands, coal bed methane reservoirs, condensate reservoirs, deep and ultradeep reservoirs, etc.) or their history (mature fields, etc.) One way to improve and accelerate hydrocarbon recovery is an effective stimulation program.
Evolution of the excitation spectrum of cuprate superconductors with doping and temperature (2010)

Understanding the mechanism by which d-wave superconductivity in the cuprates emerges and is optimized by doping a Mott insulator is one of the major outstanding problems in physics. A key unresolved question in this field is how the strength of electron pairing evolves as a function of doping and temperature and whether pairing strength and the Tc of the sample are related, as they are in simple BCS superconductors. To address these questions, we have developed several new experimental techniques with the scanning tunneling microscope to measure the excitation spectra in the cuprates on the atomic scale as a function of doping and temperature. In this thesis, we will describe these techniques as well as a series of new experiments that reveal a surprisingly simple picture of how superconductivity in the cuprates is optimized. We will first show that over a wide range of doping (optimal to overdoped), the pairing gaps in these systems nucleate in nanoscale regions at temperatures above Tc unlike in the conventional superconductors where the superconducting order parameter sets in at the bulk Tc. These regions proliferate as the temperature is lowered, resulting in a spatial distribution of gap sizes in the superconducting state. Analysis of our data shows no correlation between the inhomogeneous pairing gaps and either the energy scale of the boson modes or the strength of the local electron-boson coupling as measured by the local excitation spectra. This spatially inhomogeneous pairing strength is in fact determined by the unusual electronic excitations of the normal state, suggesting that strong electron-electron interactions rather than low-energy (&lt;0.1 eV) electron-boson interactions are responsible for superconductivity in the cuprates. In contrast, the excitation spectra in the underdoped samples show multiple features that can't be fit to a simple d-wave order parameter. However, these spectra show a universal low energy excitation spectrum, indicating that the pairing strength near the nodes is independent of doping. The transition temperature Tc in this doping regime correlates with the fraction of the Fermi surface over which the samples exhibit the universal d-wave spectrum. Optimal Tc is achieved when all parts of the Fermi surface follow this universal behavior. Increasing temperature above Tc turns the universal spectrum into an arc of gapless excitations, while overdoping breaks down the universal nodal behavior.
Immunoadsorption of Cryptococcus-specific suppressor T-cell factors (1986)

In the murine cryptococcal suppressor cell circuit, two different T-cell suppressor factors, TsF1 and TsF2, have been identified which specifically suppress the delayed-type hypersensitivity (DTH) response to cryptococcal culture filtrate antigen (CneF). TsF1 is produced by a first-order T suppressor (Ts1) cell population and suppresses the afferent limb of the DTH response, whereas TsF2 is produced by a second-order T suppressor (Ts2) cell population and suppresses the efferent limb of the cryptococcal DTH response. The objective of this study was to ascertain whether TsF1 or TsF2 could bind to cryptococcal antigen. To assess this, adsorption of TsF1 and TsF2 was performed with heat-killed Cryptococcus neoformans cells and by solid-phase immunoadsorption (SPIA) on columns containing cryptococcal antigens, i.e., CneF covalently bound to Sepharose 4B. The suppressive effect of TsF1 was removed by adsorption with intact heat-killed cryptococci and by SPIA on CneF-Sepharose 4B. The binding of cryptococcal TsF1 to the cryptococcal SPIA column was shown to be specific since Sepharose 4B columns either coupled with Saccharomyces cerevisiae mannan or blocked with glycine did not adsorb the suppressor activity. In contrast, the suppressive component of TsF2 did not bind to heat-killed cryptococci, CneF-Sepharose 4B, S. cerevisiae mannan-Sepharose 4B, or glycine-Sepharose 4B columns. These results, together with the finding that cryptococcal antigen, anticryptococcal antibody, and C1q-binding immune complexes were not demonstrated in either TsF1 or TsF2, establish that TsF1 and TsF2 can be differentiated on the basis of their affinity for cryptococcal antigen.
Resonant Photoemission at the2pEdges of Ni: Resonant Raman and Interference Effects (1997)

Unambiguous evidence for resonant photoemission in Ni is presented. Interference effects are identified at the $2p$ edges for the valence band and the 6 eV satellite. A rapid transition from a resonant Raman to an Auger-like regime shows that the core-excited states above threshold are not localized enough to significantly enhance the photoemission intensity, implying a large fraction of incoherent intensity. The results indicate that the appearance of interference effects does not require strong localization of the intermediate state.
Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation (2019)

An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in <i>r</i><sub>1</sub> at 1.4 T that was attributed to an oligomerization of the probe upon oxidation. This probe, Gd-5-HT-DOTAGA, provided specific detection of lung inflammation by MRI in bleomycin-injured mice.
Limited Control Over the Body as Intriguing Play Design Resource (2021)

Interest in combining interactive play and the human body, using “bodily play” systems, is increasing. While these systems primarily prioritize a player's control over their bodily actions, we see intriguing possibilities in the pursuit of “limited control over the body” as an intriguing design resource for bodily play systems. In this paper, we use three of our bodily play systems to illustrate how designers can engage with limited control over the body by varying the player's degree of indirect control (for instance, via other bodily activity and external triggers). We also propose four strategies for employing limited control over the body: Exploration, Reflection, Learning and Embracement. We hope our own work and the strategies developed from it will assist designers to employ limited control over the body, ultimately helping people benefit from engaging their bodies through play.
Supplemental Table S9 from The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma (2023)

&lt;p&gt;Supplemental Table S9. Fusion calls in Merkel cell carcinoma by transcriptome sequencing&lt;/p&gt;
Estimates of Cosmological Parameters Using the Cosmic Microwave Background Angular Power Spectrum of ACBAR (2003)

We report an investigation of cosmological parameters based on the measurements of anisotropy in the cosmic microwave background radiation (CMB) made by the Arcminute Cosmology Bolometer Array Receiver (ACBAR). We use the ACBAR data in concert with other recent CMB measurements to derive Bayesian estimates of parameters in inflation-motivated adiabatic cold dark matter models. We apply a series of additional cosmological constraints on the shape and amplitude of the density power spectrum and the Hubble parameter and from supernovae to further refine our parameter estimates. Previous estimates of parameters are confirmed, with sensitive measurements of the power spectrum now ranging from l ~ 3 to 2800. Comparing individual best-fit models, we find that the addition of ΩΛ as a parameter dramatically improves the fits. We also use the high-l data of ACBAR, along with similar data from the Cosmic Background Imager and Berkeley-Illinois-Maryland Association array, to investigate potential secondary anisotropies from the Sunyaev-Zel'dovich effect. We show that the results from the three experiments are consistent under this interpretation and use the data, combined and individually, to estimate σ8 from the Sunyaev-Zel'dovich component.
Wavelet Transform and Its Application to Image Coding and Processing. (1994)

新しい信号解析の手法として, 最近注目を集めているウェーブレット変換について紹介すると共に, 画像符号化と画像処理への応用という立場から眺めた際の離散ウェーブレット変換の特徴に重点を置いて最近の研究動向に関して記述する.
Magnetic probe factor with consideration of probe tilt for near-field measurement (2014)

This paper presents a frequency and space dependent analytical model of near-field magnetic probe factor with probe tilt angle for measuring electromagnetic emissions. The principle and derivation of the probe factor are elucidated. The vector-network-analyzer (VNA) measurement of the probe factor is also introduced. The correlation between the measured and calculated probe factors is finally demonstrated.
Activation of cells in a cavitation flow (2007)

A cavitation flow in an expanding nozzle is numerically simulated. The cavitation activation of cells is studied experimentally.
Aberration Correction for the Writing and Read-Out of Multi-Layer Optical Memory (2005)

We investigate using adaptive optics to improve the performance of multi-layer optical memories. A deformable membrane mirror corrects aberrations for both recording and read-out of bitwise data in stratified photochromic media, extending the useable depth.
Reliable Operation of SiC JFET Subjected to Over 2.4 Million 1200-V/115-A Hard Switching Events at 150 $^{\circ}\hbox{C}$ (2013)

A requirement for the commercialization of power SiC transistors is their long-term reliable operation under hard switching conditions and high temperatures encountered in the field. Normally ON 1200-V vertical-channel implanted-gate SiC JFETs, designed for high-power bidirectional (four-quadrant) solid-state circuit breaker applications, were repetitively pulsed hard switched at 150 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$^{\circ}\hbox{C}$ </tex></formula> from a 1200-V blocking state to an on-state current of 115 A, which is in excess of 13 times the JFET's 250- <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\hbox{W}/\hbox{cm}^{2}$ </tex></formula> rated current at 150 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$^{\circ}\hbox{C}$</tex></formula> . The JFETs were fabricated in seven photolithographic levels with a single masked ion implantation forming the <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\hbox{p}^{+}$</tex></formula> gates and guard rings and with no epitaxial regrowth. The pulsed testing was performed using a low-inductance <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$RLC$</tex> </formula> circuit. In this circuit, the energy initially stored in a capacitor is discharged in a load resistor through the JFET under test. The JFET hard switch stressing included over 2.4 million 1200-V/115-A hard switch events at 150 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$^{\circ}\hbox{C}$</tex></formula> and at a repetition rate of 10 Hz. The peak energies and powers dissipated by the JFET at each hard switch event were 73.2 mJ and 68.2 kW, respectively. The current rise rate was 166 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\hbox{A}/\mu\hbox{s}$</tex></formula> , and the pulse FWHM was 1.8 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\mu\hbox{s}$</tex></formula> . After over 2.4 million hard switch events at 150 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$^{\circ}\hbox{C}$</tex></formula> , the JFET blocking voltage characteristics remained unchanged while the on-state current conduction slightly improved, which indicate reliable operation.
A phase 2 study of nivolumab combined with ibrutinib in patients with diffuse large B-cell Richter transformation of CLL (2022)

Richter transformation (RT) is a rare complication of chronic lymphocytic leukemia (CLL) that has dismal outcomes. Upregulation of PD-1/PD-L1 drives immunological evasion in patients with RT. We hypothesized that combining nivolumab, a PD-1 blocking antibody, with the BTK inhibitor (BTKi) ibrutinib could potentiate tumor-cell killing. We conducted an investigator-initiated phase 2 clinical trial to assess the efficacy of combined nivolumab and ibrutinib in patients with diffuse large B-cell lymphoma (DLBCL) RT and CLL. Patients included were ≥18 years of age with adequate hepatic and renal function. Patients received nivolumab every 2 weeks of a 4-week cycle for a maximum of 24 cycles. A standard dose ibrutinib was initiated from cycle 2 onward and continued daily until progression. For patients who were already on ibrutinib at the time of study entry, the same was continued while nivolumab was initiated. A total of 24 patients with RT with a median age of 64.5 years (range, 47-88) were enrolled. Ten patients (42%) had received prior treatment for RT and 13 patients (54%) had received a prior BTKi. A total of 10 patients (42%) responded with a median duration of response of 15 months. The median overall survival was 13 months. Four of 24 (17%) patients had checkpoint inhibition-related immunological toxicities. In the CLL cohort, 10 patients were enrolled, of whom 3 patients converted from partial to complete remission; 1 patient had a grade 2 immunological toxicity. Combined nivolumab and ibrutinib is an active regimen for patients with DLBCL RT with an overall response rate of 42%. Given the limited treatment options for patients with RT, checkpoint inhibition provides a potential therapeutic option. This trial is registered at www.clinicaltrials.gov as #NCT02420912.
Stage-Adapted Treatment of HIV-Associated Hodgkin Lymphoma: Results of a Prospective Multicenter Study (2012)

In patients with HIV-HL, stage- and risk-adapted treatment is feasible and effective. The prognosis for patients with HIV-HL may approach that of HIV-negative patients with HL.
Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity (2017)

Nuclear hormone receptors (NRs) regulate physiology by sensing lipophilic ligands and adapting cellular transcription appropriately. A growing understanding of the impact of circadian clocks on mammalian transcription has sparked interest in the interregulation of transcriptional programs. Mammalian clocks are based on a transcriptional feedback loop featuring the transcriptional activators circadian locomotor output cycles kaput (CLOCK) and brain and muscle ARNT-like 1 (BMAL1), and transcriptional repressors cryptochrome (CRY) and period (PER). CRY1 and CRY2 bind independently of other core clock factors to many genomic sites, which are enriched for NR recognition motifs. Here we report that CRY1/2 serve as corepressors for many NRs, indicating a new facet of circadian control of NR-mediated regulation of metabolism and physiology, and specifically contribute to diurnal modulation of drug metabolism.
Soft-matter pressure sensors for turbulence detection (2019)

We present the design, fabrication, and testing of stretchable pressure sensing membranes. Two sensing techniques are demonstrated: resistive and capacitive. Both designs are incorporated in 400μm-thick films and are fabricated with thin film application of silicone and stencil/mask deposition of conductive materials. The resistive sensor utilizes room temperature liquid metal while the capacitive sensor utilizes multi-walled carbon nanotubes. Tests are performed with 18mm-diameter samples of each. Point load tests and acoustic response in an impedance tube provide feedback on sensor performance. The resistive sensor demonstrates a sensitivity of 0.045&Omega;/mm, and the sensor’s response has been characterized for in the 30Hz to 10kHz range with varying degrees of sensitivity. The capacitive sensor has a small point-load-deflection sensitivity ranging from 0.018pF/mm to 0.044pF/mm depending on capacitor diameter. Acoustic response are shown for 5Hz to 40 Hz, limited by external electronics. These devices are progress towards developing sensor networks capable of tracking aqueous turbulence.