gebhart/patrepeval huggingface dataset:
Plan anual de auditoría interna basado en el enfoque de riesgos para las empresas comercializadoras de electrodomésticos en la zona metropolítana de San Salvador. (2014)

En el pais, ha existido poco interes por parte de los empresarios en mantener dentro de sus empresas un departamento de auditoria interna, que le permita con su trabajo independiente y objetivo dar valor agregado a la organizacion. Debido a las nuevas exigencias de los mercados, las empresas salvadorenas se han visto en la necesidad de incluir dentro de ellas un departamento de auditoria interna; no obstante para muchos empresarios unicamente es el cumplimiento de un requisito, visto como un mal necesario y no como un aliado estrategico que le permitira en cada gestion dar valor a su organizacion. Por tal motivo el profesional de la auditoria interna, se encuentra en un momento de constante lucha, buscando hacer enfasis en la importancia de la profesion y los beneficios que esta puede aportar a los empresarios. En vista de las limitaciones que poseen los auditores internos, el proposito del presente trabajo de investigacion, es brindar un plan anual de trabajo basado en el enfoque de riesgos para las empresas comercializadoras de electrodomesticos en la zona metropolitana de San Salvador. Para la elaboracion de dicho trabajo de investigacion, se tomaron como fuente principal de informacion, a los profesionales en contaduria publica que desarrollan su labor de auditor interno en estas empresas; la informacion fue recabada a traves de cuestionarios. De igual forma se obtuvo datos importantes por medio de entrevistas, la cual permitio tambien obtener un criterio mucho mas claro de la situacion de los auditores internos y la importancia de contar con departamento de auditoria dentro de estas organizaciones. De acuerdo a los resultados obtenidos de la investigacion, se encontro que las empresas dedicadas a la comercializacion de electrodomesticos que ostentan la clasificacion de grandes (segun la DIGESTYC), el 63% de ellas no realizan un plan anual de trabajo, por lo tanto la elaboracion de este con enfoque de riesgos sera de mucho beneficio para los profesionales que laboran para dichas empresas, asi como tambien a todos aquellos estudiantes y profesionales que lo requieran. La falta de elaboracion de un plan anual de trabajo de auditoria con enfoque de riesgo, limita a los auditores internos a realizar su trabajo de manera que garantice que los resultados obtenidos son optimos y que ayuden a agregar valor a la organizacion. Ademas las unidades de auditoria interna no cuentan con un estatuto que les garantice el desempeno de sus labores de forma independiente y objetiva.
Voltage-Sensitive Calcium Channels in Osteoblasts: Mediators of Plasma Membrane Signalling Events (1996)

Voltage-Sensitive Calcium Channels (VSCCs) are important cell surface regulators of membrane permeability to Ca2+. In non-excitable cells such as osteoblasts, VSCCs act as cellular transducers of stimulus-secretion coupling, activators of intracellular proteins, and in control of cell growth and differentiation. To obtain information concerning the molecular identity of the osteoblastic VSCC, we used an RT-PCR regional amplification approach. Effort focused on the large membrane-spanning alpha 1 subunit that is responsible for ion translocation. We designed primers using conserved alpha 1 subunit sequences common to many channel isoforms from various tissues and species. The generation of several RT-PCR products from various osteoblastic cell lines and subsequent sequencing of these products indicated that osteoblasts express at least two variants of the L-type VSCC which share regions of identity to the CaCh2 isoform first identified in cardiac myocytes. Our work provides the first molecular evidence for the existence and identity of VSCCs present in osteoblasts.
Non-Contact ECG Sensing Employing Gradiometer Electrodes (2012)

Noncontact, capacitive electrocardiogram (ECG) measurements are complicated by motion artifacts from the relative movement between the ECG electrodes and the subject. To compensate for such motion we propose to employ first and second order gradiometer electrode designs. A MATLAB-based simulation tool to enable assessment of different electrode configurations and placements on human subjects has been developed to guide the refinement of electrode designs. Experimental measurements of the sensitivity, motion artifact cancellation, and common mode rejection for various prototype designs were conducted with human subjects. Second order gradiometer electrode designs appear to give the best performance as measured by signal to noise plus distortion ratio. Finally, both gradiometer designs were compared with standard ECG recording methods and showed less than 1% beat detection mismatch employing an open source beat detection algorithm.
Cross-Reactive HIV-1 Neutralizing Human Monoclonal Antibodies with Unique Features: Structural Mimicry of CD4, Conformational Flexibility, Lack of Light Chain (2005)

DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone.
The Phytostilbene Resveratrol Induces Apoptosis in INS-1E Rat Insulinoma Cells (2009)

We investigated the effect of resveratrol on proliferation and induction of apoptosis of INS-1E rat insulinoma cells by cell counting, crystal violet staining, flow cytometry and immunoblotting. Resveratrol treatment of INS-1E cells at concentrations > or =50 microM resulted in a dose-dependent inhibition of cell proliferation, accumulation of the cells in the S and G0/G1 phase and a significant increase of the percentage of apoptotic cells. This was paralleled by an increase of cell granularity, apoptotic volume decrease (AVD), exposure of phosphatidylserine at the outer leaflet of the plasma membrane, an increase of the 7-AAD signal and caspase activation. The AMP-kinase (AMPK) inhibitor compound C (10 microM) significantly inhibited cell proliferation and induced caspase activation within 48 hours but this effect was not modified by resveratrol suggesting that AMPK is not a major target involved in mediating the proapoptotic effect of resveratrol in INS-1E cells. Immunoblotting revealed a significant inhibition of Akt (PKB) phosphorylation by 100 muM resveratrol within 1 hour. Addition of insulin (10 microM) to the culture medium strongly enhanced basal Akt phosphorylation. This enhancement was significantly attenuated by 50 and 100 microM resveratrol. We conclude that the antiproliferative/proapoptotic effect of resveratrol on INS-1E cells is due to negative interference with Akt signaling and most likely disruption of auto/paracrine insulin signaling.
A new potent morphological non-invasive technique to assess liver Fibrosis : Part I, Technical feasibility (2010)

International audience
12‐2: Development of Top‐Gate Oxide TFTs for Plastic‐Film LCDs (2018)

A thin‐film‐transistor (TFT) technology for plastic‐film liquid crystal displays (LCDs) was developed herein. Top‐gate oxide TFTs with channel lengths L = 2 and 3 μm were fabricated on a transparent polyimide layer at approximately &lt;300 °C using Generation 4.5 mother glass. The desirable performance and reliability of the TFTs were obtained.
A New Approach for an End-to-end Communication System Using Variational Auto-encoder (VAE) (2022)

In this paper, a new approach has been proposed and investigated with the help of variational auto-encoder (VAE) as a probabilistic model to reconstruct the transmitted symbol without sending the data bits out of the transmitter. The novelty of the proposed End-to-end (E2E) wireless system is in representing the symbol as a image hot vector (IHV) that contains the features of the shape such as spikes, closed squared frame, pixels index location and pixels grey-scale colours. The previously mentioned features are inferred by latent random variables (LRVs). The LRVs are used for fronthaul and backhaul data representation. The LRVs parameters have only been transmitted through the physical wireless channel instead of the original bits as in the classical modulations or the hot vectors in the Auto-encoders (AE) E2E systems. The new proposed VAE architecture achieved the reconstruction of the symbol from the received LRV. The results show that the VAE with a simple classifier can provide a better symbol error rate (SER) than both AE baseline and classical Hamming code with hard decision decoding, especially at high <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$E_{b}/N_{o}$</tex> .
A 78 dB SNDR 87 mW 20 MHz Bandwidth Continuous-Time $\Delta\Sigma$ ADC With VCO-Based Integrator and Quantizer Implemented in 0.13 $\mu$m CMOS (2009)

The use of a VCO-based integrator and quantizer within a continuous-time (CT) ΔΣ analog-to-digital converter (ADC) structure is explored, and a custom prototype in a 0.13 μm CMOS with a measured performance of 81.2/78.1 dB SNR/SNDR over a 20 MHz bandwidth while consuming 87 mW from a 1.5 V supply and occupying an active area of 0.45 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> demonstrated. A key innovation is the explicit use of the oscillator's output phase to avoid the signal distortion that had severely limited the performance of earlier VCO-based ADCs, which had made use of its output frequency only. The proposed VCO-based integrator and quantizer structure enables fourth-order noise shaping with only three opamp-based integrators.
Real-time Millimeter Wave Omnidirectional Channel Sounder Using Phased\n Array Antennas (2020)

Characterization of the millimeter wave wireless channel is needed to\nfacilitate fully connected vehicular communication in the future. To study the\nmultipath-rich, rapidly varying nature of the vehicular propagation\nenvironment, fast millimeter wave channel sounders are required. We present a\nchannel sounder design capable of covering 360 degrees in azimuth and 60\ndegrees in elevation with 200 individual beam directions in 6.25 ms by using\nfour phased arrays simultaneously. The channel measurements are accompanied by\nhigh resolution positioning and video data, allowing channel sounding to be\nconducted while either the transmitter, or the receiver, or both are moving.\nChannel sounding campaigns were conducted at multiple urban locations with\nlight traffic conditions in Austin, Texas. Preliminary results show that beam\nselection at the receiver can lower the effective pathloss exponent to 1.6 for\nline-of-sight and 2.25 for non line-of-sight.\n
Next generation sequencing (NGS) in resectable non-small cell lung cancer (NSCLC): Therapeutic implications. (2016)

8541 Background: Tumor molecular profiling to direct therapy is standard for patients with advanced lung adenocarcinoma (AC) but is not routine in early stage NSCLC. Clinical trials are only beginning to test this approach for postoperative adjuvant therapy. After systematic preoperative consent and tumor/blood acquisition, we analyzed molecular profiling data in resectable NSCLC to enhance clinical trial participation and design. Methods: Prospective genomic analysis of resectable NSCLC was initiated in 2015 using MSK-IMPACT, a multiplexed NGS assay that detects base substitutions, short indels, copy number alterations and select gene rearrangements involving 341 (v1) or 410 (v2) cancer associated genes. Frequencies of mutations are summarized by histology (AC or squamous cell). AC further classified by histologic predominance as good (lepidic, MIA), intermediate (acinar, papillary), poor (micropapillary, solid) prognosis. Results: 123 tumors from 119 consecutive patients (4 synchronous 10); median age 67.8; 80(67%) females; 96(81%) Caucasian, 5(4.2%) Asian; 15 (13%) never smokers, median 26 pk/yrs smoking; 98 (80%); pStage I/II 103(84%). 60 AC (59%) had multiple mutations, predominantly EGFR+TP53 and KRAS+STK11. Conclusions: Initial experience shows a high frequency of multiple targetable mutations in resectable NSCLC that can be used to direct patients to appropriate adjuvant therapy trials. Mutations All AC * (N=102; 83%) AC Good (N=14; 14%) AC Intermediate (N=59; 58%) AC Poor (N=26; 26%) Squamous (SCC) (N=12; 10%) EGFR 28 (28%) 3 (21%) 22 (37%) 3 (12%) 1** KRAS 45 (44%) 6 (43%) 25 (42%) 13 (50%) 1 ALK 3 0 0 2 0 ROS1 3 1 1 0 0 BRAF 8 3 3 2 0 RET 5 1 1 3 0 MET ex14 3 1 0 2 0 MET other 6 0 3 3 0 ERBB2 0 0 0 0 0 TP53 42 (41%) 3 (21%) 25 (42%) 13 (50%) 10 STK11 22 (22%) 1 (7.1%) 14 (24%) 6 (23%) 1 Rb1 5 1 2 1 1 PTEN 1 1 0 0 1 P1K3CA 8 1 5 2 1 Data shown exclude carcinoid, SCLC, pleomorphic tumors (n=9); *histologic predominance unavailable (n=3); **amplification.
Antigen-Driven Patterns of TCR Bias Are Shared across Diverse Outcomes of Human Hepatitis C Virus Infection (2010)

Hepatitis C virus (HCV) infection causes significant morbidity and mortality worldwide. T cells play a central role in HCV clearance; however, there is currently little understanding of whether the disease outcome in HCV infection is influenced by the choice of TCR repertoire. TCR repertoires used against two immunodominant HCV determinants--the highly polymorphic, HLA-B*0801 restricted (1395)HSKKKCDEL(1403) (HSK) and the comparatively conserved, HLA-A*0101-restricted, (1435)ATDALMTGY(1443) (ATD)--were analyzed in clearly defined cohorts of HLA-matched, HCV-infected individuals with persistent infection and HCV clearance. In comparison with ATD, TCR repertoire selected against HSK was more narrowly focused, supporting reports of mutational escape in this epitope, in persistent HCV infection. Notwithstanding the Ag-driven divergence, T cell repertoire selection against either Ag was comparable in subjects with diverse disease outcomes. Biased T cell repertoires were observed early in infection and were evident not only in persistently infected individuals but also in subjects with HCV clearance, suggesting that these are not exclusively characteristic of viral persistence. Comprehensive clonal analysis of Ag-specific T cells revealed widespread use of public TCRs displaying a high degree of predictability in TRBV/TRBJ gene usage, CDR3 length, and amino acid composition. These public TCRs were observed against both ATD and HSK and were shared across diverse disease outcomes. Collectively, these observations indicate that repertoire diversity rather than particular Vβ segments are better associated with HCV persistence/clearance in humans. Notably, many of the anti-HCV TCRs switched TRBV and TRBJ genes around a conserved, N nucleotide-encoded CDR3 core, revealing TCR sequence mosaicism as a potential host mechanism to combat this highly variant virus.
General-purpose Tagging of Freesound Audio with AudioSet Labels: Task Description, Dataset, and Baseline (2018)

Comunicació presentada a: Detection and Classification of Acoustic Scenes and Events 2018, celebrat a Surrey, Regne Unit, del 19 al 20 de novembre de 2018.
Closed-Form Global Optimization of Beyond Diagonal Reconfigurable Intelligent Surfaces (2023)

Reconfigurable intelligent surfaces (RISs) allow controlling the propagation environment in wireless networks by tuning multiple reflecting elements. RISs have been traditionally realized through single connected architectures, mathematically characterized by a diagonal scattering matrix. Recently, beyond diagonal RISs (BD-RISs) have been proposed as a novel branch of RISs whose scattering matrix is not limited to be diagonal, which creates new benefits and opportunities for RISs. Efficient BD-RIS architectures have been realized based on group and fully connected reconfigurable impedance networks. However, a closed-form solution for the global optimal scattering matrix of these architectures is not yet available. In this paper, we provide such a closed-form solution proving that the theoretical performance upper bounds can be exactly achieved for any channel realization. We first consider the received signal power maximization in single-user single-input single-output (SISO) systems aided by a BD-RIS working in reflective or transmissive mode. Then, we extend our solution to single-user multiple-input multiple-output (MIMO) and multi-user multiple-input single-output (MISO) systems. We show that our algorithm is less complex than the iterative optimization algorithms employed in the previous literature. The complexity of our algorithm grows linearly (resp. cubically) with the number of RIS elements in the case of group (resp. fully) connected architectures.
Motorized capsule for shadow-free OCT imaging and synchronous beam control (2019)

We demonstrate a tethered motorized capsule for unobstructed optical coherence tomography (OCT) imaging of the esophagus. By using a distal reflector design, we avoided the common shadow artifact induced by the motor wires. A synchronous driving technique features three types of beam-scanning modes of the capsule, i.e., circumferential beam scanning, localized beam scanning, and accurate beam positioning. We characterized these three modes and carried out ex vivo imaging experiments using the capsule. The results show that the capsule can potentially be a useful tool for diagnostic OCT imaging and OCT-guided biopsy and therapy of the esophagus.
Effect of high-temperature drying of recycled paper on heat transfer rates and sheet properties (2009)

A gas-fired paper dryer (GFPD) was evaluated in pilot- and full-scale environments. A corresponding study was done on the effect of high temperature on paper drying rates and paper properties. The process variables studied include temperature, moisture level, refining, and basis weight. In an ideal location, heat transfer rates are maximized with a minimum effect on sheet properties. Sheet curl is a function of recycling, refining, basis weight, and drying temperatures and can be minimized by correct placement of the GFPD. Results of this study indicate optimal installation location. The heat transfer coefficient is independent of the shell temperature in the constant rate drying zone and in the first following rate zone, but decreases with an increase in shell temperature in the second following rate zone. If a gas-fired dryer is located in either the constant rate zone or in the first following rate zone, the overall drying rate increases by approximately two to four percent per single gas-fired cylinder. By using several gas-fired dryers, it is possible to increase the overall drying rate by as much as 20%.
Real-Time Parameter Estimation in Back-EMF Self-Sensing Mode with the Synergy of Induction Machine Deadbeat-Direct Torque and Flux Control Drives (2018)

Back-EMF self-sensing is commonly used in induction machine (IM) drive systems for cost and reliability considerations. Deadbeat-direct torque and flux control (DB-DTFC) has shown to be a highly effective method for IM control with a fixed switching frequency. Accurate machine parameters are critical for low speed back-EMF self-sensing and low speed DB-DTFC. Using unique properties of IM DB-DTFC drives, this paper proposes a general solution for real-time parameter estimation in the back-EMF self-sensing mode. The paper documents the low speed parameter sensitivity of back-EMF self-sensing based IM DB-DTFC drives. The paper then recognizes the potential synergy of IM back-EMF self-sensing and DB-DTFC and investigates two real-time parameter estimation methods based on flux injection and based on model reference adaptive systems (MRAS). Finally, by considering properties of the two methods, an operating region-based real-time parameter estimation system in IM DB-DTFC self-sensing drives is proposed and experimentally evaluated.
A Membrane‐Intercalating Conjugated Oligoelectrolyte with High‐Efficiency Photodynamic Antimicrobial Activity (2017)

A membrane-intercalating conjugated oligoelectrolyte (COE), PTTP, was designed and synthesized with the goal of providing red-shifted absorption spectra relative to previously synthesized COE analogs. Specifically, electron-rich and electron-poor subunits were introduced in the conjugated backbone to modulate the band gap. PTTP exhibits maxima of absorption at 507 nm and of emission at 725 nm. PTTP can also efficiently function to generate singlet oxygen in situ (Φ<sub>Δ</sub> ≈20 %) and has appropriate topology and dimensions to interact with lipid membranes. The resulting rapid membrane insertion and sensitizing ability provide PTTP with a highly efficient antibacterial capability under a low light dose (0.6 J cm<sup>-2</sup> ) toward Gram-negative bacteria E. coli, making it a remarkably efficient optically mediated antimicrobial agent.
Toughening of epoxy novolac resin using cardanol based flexibilizers (2015)

ABSTRACT In this work, two different cardanol based epoxies (Cardolite NC‐514 and Cardanol NC‐547) were employed as flexibilizers to toughen an epoxy novolac resin namely, poly[(phenylglycidyl ether)‐ co ‐formaldehyde] (PPGEF). 4,4′‐Diamino‐3,3′‐dimethyl dicyclohexyl methane (BMCHA) was used as a curing agent. Differential scanning calorimetry and dynamic mechanical thermal analysis of the composites showed a gradual decrease in glass transition temperatures ( T g ) with increase in cardolite content confirming the incorporation of flexible moieties into the brittle resin matrix. Improvement in toughening of PPGEF/Cardolite composites was manifested by increase in the izod impact strength of both the composites. The tensile strength increased marginally for composites with increasing amount of Cardolite NC‐514 but decreased for the composites containing Cardolite NC‐547. This was attributed to the lack of rotational motion in the chain due to close proximity of rigid phenyl rings in NC‐547. SEM of the cryo‐fractured surfaces of composites showed good compatibility between PPGEF and cardanol based flexibilizers. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43318.
Comparison of hydrogen and chlorine atom abstraction reactions of triplet carbenes in low-temperature matrixes (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of hydrogen and chlorine atom abstraction reactions of triplet carbenes in low-temperature matrixesB. B. Wright, K. Kanakarajan, and M. S. PlatzCite this: J. Phys. Chem. 1985, 89, 16, 3574–3577Publication Date (Print):August 1, 1985Publication History Published online1 May 2002Published inissue 1 August 1985https://pubs.acs.org/doi/10.1021/j100262a030https://doi.org/10.1021/j100262a030research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts