gebhart/patrepeval huggingface dataset:
1,4-Bis(trimethylsilyl)but-2-ene-1,4-diyl Complexes of Lithium, Magnesium, Aluminum, and Gallium (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1,4-Bis(trimethylsilyl)but-2-ene-1,4-diyl Complexes of Lithium, Magnesium, Aluminum, and GalliumMichael G. Gardiner, Colin L. Raston, F. Geoffrey N. Cloke, and Peter B. HitchcockCite this: Organometallics 1995, 14, 3, 1339–1353Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/om00003a040https://doi.org/10.1021/om00003a040research-articleACS PublicationsRequest reuse permissionsArticle Views245Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Ambient Air Pollution Associations with Retinal Morphology in the UK Biobank (2020)

Greater exposure to PM2.5, PM2.5 absorbance, and nitrogen oxides were all associated with apparently adverse retinal structural features.
Biological Augmentation of Rotator Cuff Repair (2015)

Biological therapies that can augment tendon to bone healing are desirable for the management of clinical conditions such as failed rotator cuff (RC) repair, chronic retracted RC tears, and RC tears in a compromised host (smokers, chronic medical conditions including diabetes). Bone marrow aspirate and platelet-rich plasma are 2 autologous biological therapies that are currently being used clinically to augment tendon to bone healing. The indications for this biological therapy, its efficacy, duration, dosage, and optimum cellular concentration are in the process of evolution and require continued ongoing investigations for further optimization. In this technique article, we describe the biological basis and our technique for the preparation and use of platelet-rich plasma and bone marrow aspirate for augmentation of RC repair.
Hydrogen isotope separation methods and systems (2023)

Methods and systems for the separation of hydrogen isotopes from one another are described. Methods include utilization of a hydrogen isotope selective separation membrane that includes a hydrogen isotope selective layer (e.g., graphene) and a hydrogen ion conductive supporting layer. An electronic driving force encourages passage of isotopes selectively across the membrane at an elevated separation temperature to enrich the product in a selected hydrogen isotope.
Network Mobility (2011)

Network mobility (NEMO) management is concerned about the mobility management of an entire wireless mobile network to provide uninterrupted network connectivity to many mobile devices moving together in the mobile network. This is particularly important for ubiquitous computing, which commonly means anytime, anywhere computing and communication. Most of the 3G and entire 4G and beyond wireless communication technology is all-IP. This growing use of IP devices in portable applications has created the demand for mobility support for entire networks of IP devices. NEMO solves this problem by extending Mobile IP. Devices on a mobile network are unaware of their network’s mobility; however, they are provided with uninterrupted Internet access even when the network changes its attachment point to the Internet. The main objective of NEMO is to provide continuous, optimal, and secure Internet access to all nodes and even recursively nested mobile sub-nets inside a moving network. Internet Engineering Task Force (IETF) is engaged in standardizing NEMO Basic Support protocol that ensures uninterrupted connectivity to nodes within a mobile network via a mobile router. This protocol extends the mechanisms utilized in the host mobility management protocol Mobile IPv6. There are few open problems remain to be addressed in NEMO. In this chapter, we discuss about NEMO basic support protocols, its features, and other related issues.
The trispectrum of the cosmic microwave background on subdegree angular scales: an analysis of the BOOMERanG data (2003)

The trispectrum of the cosmic microwave background can be used to assess the level of non-Gaussianity on cosmological scales. It probes the fourth-order moment, as a function of angular scale, of the probability distribution function of fluctuations and has been shown to be sensitive to primordial non-Gaussianity, secondary anisotropies (such as the Ostriker-Vishniac effect) and systematic effects (such as astrophysical foregrounds). In this paper we develop a formalism for estimating the trispectrum from high-resolution sky maps that incorporates the impact of finite sky coverage. This leads to a series of operations applied to the data set to minimize the effects of contamination due to the Gaussian component and correlations between estimates at different scales. To illustrate the effect of the estimation process, we apply our procedure to the BOOMERanG data set and show that it is consistent with Gaussianity. This work presents the first estimation of the cosmic microwave background trispectrum on subdegree scales.
Lithium Battery Cathodes: Concurrently Approaching Volumetric and Specific Capacity Limits of Lithium Battery Cathodes via Conformal Pickering Emulsion Graphene Coatings (Adv. Energy Mater. 25/2020) (2020)

The cover image representing article number 2001216, by Mark C. Hersam and co-workers depicts a schematic of battery cathode particles that have been conformally coated with graphene using a scalable Pickering emulsion approach. This strategy provides high electrical conductivities at tenfold lower conductive additive loadings than conventional battery electrodes. The resulting electrodes approach theoretical volumetric and specific capacity limits without tradeoffs in cycle life, rate capability, or active material areal loading.
Comparing RTL and high-level synthesis methodologies in the design of a theora video decoder IP core (2009)

An important share of the consumer electronics market is focused on devices capable of running multimedia applications, like audio and video decoders. In order to achieve the performance level demanded by these applications, it is important to develop specialized hardware IPs in order to cope with the most computational intensive parts. Nowadays, designers are facing the challenge of integrating several components, including processor, memory, and specialized IP cores, into a single chip, giving raise to the so called systems-on-chip (SoC). The high complexity of such systems and the strict time-to-market in the electronics industry motivated the introduction of new design methodologies during the last years. This work presents a comparison between two hardware development methodologies in order to design a Theora video decoder IP core from algorithm down to FPGA.We first implemented it in hand-written RTL code using VHDL, resulting in a 56% time reduction in the decoding process when compared to a software library. The second methodology implements the same hardware using SystemC and behavioral synthesis. The second IP core was developed in 70% less time with satisfactory results. We compare the two approaches in terms of area and latency.
Testicular Endocrine Function in GH Receptor Gene Disrupted Mice (2001)

The consequences of disruption of GH receptor gene in GH receptor knockout mice on testicular function were evaluated. Adult male GH receptor knockout mice and their normal siblings were divided in to two subgroups and treated with either saline or ovine LH (0.3 microg/g BW) in saline. One hour after saline or LH administration, blood was obtained via heart puncture. Plasma IGF-I, LH, FSH, PRL, androstenedione, and testosterone levels were measured by RIAs. Testicular LH and PRL receptor numbers as well as pituitary LHbeta-subunit and testicular sulfated glycoprotein-2 mRNA levels were measured. Also, testicular morphometric analysis was performed. Unlike in normal, wild-type mice, the circulating IGF-I was undetectable in GH receptor knockout mice. The plasma PRL levels were (P<0.01) higher in GH receptor knockout mice than in their normal siblings. The basal LH secretion was similar in normal and GH receptor knockout mice. However, the circulating FSH levels were lower (P<0.001) in GH receptor gene disrupted mice. Administration of LH resulted in a significant (P<0.001) increase in plasma testosterone levels in both GH receptor knockout and normal mice. However, this testosterone response was attenuated (P < 0.01) in GH receptor knockout mice. Plasma androstenedione responses were similar in both GH receptor knockout and normal mice. Testicular LH and PRL receptor numbers were significantly decreased in GH receptor knockout mice. The results of the morphometric analysis of the testis revealed that the Leydig cell volume per testis was reduced in mice with GH receptor gene disruption. The steady-state of LHbeta-subunit and testicular sulfated glycoprotein-2 mRNA levels were not different in GH receptor knockout mice relative to their normal siblings. The present in vivo study demonstrates that in GH receptor knockout mice, LH action on the testis in terms of testosterone secretion is significantly attenuated and suggests that this is due to a decrease in the number of testicular LH receptors. The reduced number of PRL receptors may contribute to the diminished responsiveness of testicular steroidogenesis to LH by decreased ability to convert androstenedione to testosterone. These changes are most likely due to the absence of circulating IGF-I. These findings provide evidence that systemic IGF-I plays a major modulatory role in testicular endocrine function.
Biocompatible self-assembly of nano-materials for Bio-MEMS and insect reconnaissance. (2003)

This report summarizes the development of new biocompatible self-assembly procedures enabling the immobilization of genetically engineered cells in a compact, self-sustaining, remotely addressable sensor platform. We used evaporation induced self-assembly (EISA) to immobilize cells within periodic silica nanostructures, characterized by unimodal pore sizes and pore connectivity, that can be patterned using ink-jet printing or photo patterning. We constructed cell lines for the expression of fluorescent proteins and induced reporter protein expression in immobilized cells. We investigated the role of the abiotic/biotic interface during cell-mediated self-assembly of synthetic materials.
Supplementary Data from Targeting BET Proteins BRD2 and BRD3 in Combination with PI3K-AKT Inhibition as a Therapeutic Strategy for Ovarian Clear Cell Carcinoma (2023)

&lt;p&gt;Supplementary Figure 2. Gene Ontology (GO) enrichment analysis indicates OCI-C5x cells are more vulnerable to epigenetic interventions than OCI-P5x cells&lt;/p&gt;
202 In vivo and in vitro characterization of AIM ACT, a novel nanoparticle-based technology, expanded MART-1 specific T cells (2021)

<h3>Background</h3> NexImmune is developing highly differentiated immunotherapies to target, activate and expand tumor antigen-specific T cells using the proprietary Artificial Immune Modulation (AIM™) nanotechnology platform. The AIM nanoparticle (AIM-np) technology functions as synthetic dendritic cells capable of directing a specific T cell-mediated immune response. By mimicking natural T cell biology, NexImmune’s non-genetically engineered cellular therapy product candidates (AIM ACT) are designed to combine the attributes of cellular precision, potency, and persistence with reduced potential for undesired toxicities. <h3>Methods</h3> Here we present an example of AIM ACT expanded MART-1 specific T cells and their phenotypic and functional characterization in vitro and in vivo. Leukopaks from healthy donors were used to produce AIM ACT T cell products with our proprietary AIM ACT enrichment and expansion (E+E) manufacturing process and antigen peptide-loaded AIM-nanoparticles. <h3>Results</h3> The final MART1 T cell products include up to 62.8% (20.8% in average) MART-1-specific CD8+ T cells as determined by MART1 peptide (ELAGIGILTV)-loaded multimer staining. MART1-specific T cells were tested in flow cytometry-based and live cell imaging-based cytotoxicity assays using HLA-A2 positive MART1 peptide-loaded target cells. The AIM ACT-generated T cells showed potent cytotoxicity to MART1 peptide-loaded target cells in vitro, while unloaded control cells were not killed. In over 30 independent AIM ACT E+E clinical scale runs, the expanded T cells consisted of a combined average of 91.7% T stem cell like, central and effector memory T cells, as determined by CD62L, CD45RA and CD95 staining. These phenotypes have been associated with long term in vivo persistence and anti-tumor efficacy. In a human melanoma PDX model, we confirmed that transfusion of AIM ACT T cells resulted in long term survival in vivo and significant reduction of tumor growth with complete tumor clearance in 6 out of 15 animals. <h3>Conclusions</h3> The results demonstrate that AIM ACT MART1 T cells have long term persistence and anti-tumor activity in solid tumors such as melanoma, and that the AIM ACT E+E approach is a reproducible clinical scale manufacturing process for non-genetically engineered antigen-specific T cells. The AIM ACT platform is currently being used for generating T cell products for our current clinical trials, NEXI-001 (NCT04284228) and NEXI-002 (NCT04505813), and our pre-clinical development for HPV-associated malignancies. The findings support initiating Phase I trials of adoptive T cell therapy in solid tumors. <h3>Ethics Approval</h3> The study was approved by the Institutional Animal Care and Use Committee (IACUC).
Synthesis and Characterization of Tris(β‐ketoiminato)ruthenium(III) Complexes: Potential Precursors for CVD of Ru and RuO2 Thin Films (2004)

Abstract The synthesis and characterization of Ru III metal complexes [Ru(keim1) 3 ] ( 1 ) and [Ru(keim2) 3 ] ( 2 ) are reported, where (keim)H is an abbreviation for the fluorinated ketoimine ligands with formula HOC(CF 3 )=CHCR=NMe; (keim1)H with R = Me and (keim2)H with R = CF 3 . These newly synthesized complexes were characterized by spectroscopic methods, while the second complex, 2 , was further examined by single‐crystal X‐ray diffraction (XRD), revealing an octahedral coordination for the Ru cation, with three ketoiminate arranged in a mer ‐configuration, a consequence of the enhanced steric interaction between ligands. Moreover, both Ru metal complexes show good volatility and thermal stability. CVD experiments were conducted using these complexes at temperatures of 325–450 °C. The Ru metal and RuO 2 thin films on silicon wafers were successfully obtained using either a mixture of 2 % O 2 in argon or pure O 2 as the carrier gas, respectively. Our result shows that a 2 % O 2 concentration induces the formation of Ru metal, while that only complex 1 gives formation of a columnar RuO 2 phase upon switching to pure O 2 as the CVD carrier gas. Scanning electron microscopy (SEM) images were taken to reveal surface morphologies, while X‐ray photoelectron spectroscopy (XPS) and XRD were utilized to access their atomic composition as well as the intrinsic packing of the as‐deposited thin film materials.
Electrostatic Dehydration of Heavy Oil from Polymer Flood with Partially Hydrolyzed Polyacrylamide (2013)

Abstract Polymer flood using partially hydrolyzed polyacrylamide (HPAM) has been proven to be an effective method to increase oil recovery. However, when HPAM breaks through the reservoir and shows up in the produced fluids, it brings unique emulsion characteristics and challenges to the separation processes. Operators have experienced frequent equipment failures on heat exchangers and heating elements. Traditional oil dehydration uses mechanical heater treaters which rely on elevated temperature to improve the settling of the dispersed water phase. In HPAM flood, the fire tubes in these mechanical heater treaters have become problematic and experienced repetitive failures. Electrostatic technology uses the response to the electrostatic field by the polar dispersed water phase to enhance the water settling. Electrostatic technology has been a proven technology for oil dehydration and desalting for water flood and other recovery methods such as Steam Assisted Gravity Drainage (SAGD), but not widely used in HPAM flood. A joint study was conducted between Cameron and Cenovus to evaluate the electrostatic dehydration of the heavy oil from HPAM flood. The results of the study indicate that, due to the presence of HPAM in water, the electrostatic dehydration of the wet oil from HPAM flood demonstrates some unique characteristics. Electrostatic dehydrators can achieve about 300% of the capacity of mechanical heater treaters. Proper equipment and process designs are important to reduce the equipment failures. The results of the study offer a more effective oil dehydration technology to the HPAM flood producers. The benefits of electrostatic dehydration can be especially valuable for the offshore implementation of HPAM flood due to the space and weight savings.
Estimation of internal uterine pressure by joint amplitude and frequency analysis of electrohysterographic signals (2008)

Monitoring the uterine contraction provides important prognostic information during pregnancy and parturition. The existing methods employed in clinical practice impose a compromise between reliability and invasiveness. A promising technique for uterine contraction monitoring is electrohysterography (EHG). The EHG signal measures the electrical activity which triggers the contraction of the uterine muscle. In this paper, a non-invasive method for intrauterine pressure (IUP) estimation by EHG signal analysis is proposed. The EHG signal is regarded as a non-stationary signal whose frequency and amplitude characteristics are related to the IUP. After acquisition in a multi-channel configuration, the EHG signal is therefore analyzed in the time-frequency domain. A first estimation of the IUP is then derived by calculation of the unnormalized first statistical moment of the frequency spectrum. The estimation accuracy is finally increased by identification of a second-order polynomial model. The proposed method is compared to root mean squared analysis and optimal linear filtering and validated by simultaneous measurement of the IUP on nine women during labor. The results suggest that the proposed EHG signal analysis provides an accurate estimate of the IUP.
Effect of Mint Distillation Waste on Soil Microbial Biomass in a Mint-Mustard Cropping Sequence (2004)

Abstract Field experiments were conducted for two years (1997–1999) at the Central Institute of Medicinal and Aromatic Plants (CIMAP) in Lucknow, India, to study the influence of single and combined application of organic manure and inorganic fertilizers on growth and essential oil yield of Japanese mint (Mentha arvensis) in mint-mustard cropping sequence. In the original experiment, eight treatments comprising different combinations of manure (FYM) and fertilizer NPK (applied through urea, single superphosphate and muriate of potash, respectively) were compared. Attempts were also made to elucide the changes in soil organic carbon (C), soil microbial C, nitrogen (N), and phosphorus (P), and mineralizable C and N. This article deals with the influence of inorganic fertilizer [nitrogen–phosphorus–potassium (NPK)] and organic manure (FYM, mint distillation waste) on changes in soil organic C and microbial C, N, and P in mint-fallow-mustard cropping sequence. The data indicates that while inorganic NPK did not have any direct influence on soil microbial biomass, integrated nutrient supply, residue (distillation waste of mint) and type of cropping have been observed to have significant influence on build up of microbial biomass in soil.
Biaxiality in a Cyclic Thermotropic Nematic Liquid Crystal (1994)

Birefringence and textural data are presented for a ring-shaped trimeric liquid crystal. The material apparently undergoes a uniaxial-to-biaxial nematic phase transition as a function of temperature.
Antiplatelet Activity of Valproic Acid Contributes to Decreased Soluble CD40 Ligand Production in HIV Type 1-Infected Individuals (2010)

CD40L is a type II membrane glycoprotein of the TNF family that is found on activated T cells, B cells, and platelets. We previously reported that the soluble form of this inflammatory mediator (sCD40L) is elevated in the plasma and cerebrospinal fluid of HIV-1-infected, cognitively impaired individuals. In this study, we demonstrate that the mood-stabilizing drug valproic acid (VPA) reduces sCD40L levels in plasma samples of HIV-1-infected patients (n = 23) and in washed human platelets, which are the main source of circulating sCD40L. VPA also inhibited HIV-1 transactivator of transcription-induced release of sCD40L and platelet factor 4 in C57BL/6 mice. The mechanism by which VPA was able to do so was investigated, and we demonstrate that VPA, a known glycogen synthase kinase 3β inhibitor, blocks platelet activating factor-induced activation of glycogen synthase kinase 3β in platelets in a manner that alters sCD40L release from platelets. These data reveal that VPA has antiplatelet activity, and they convey important implications for the potential of VPA as an adjunct therapy not only for cognitively impaired patients with HIV-1 infection, but also numerous inflammatory diseases for which such antiplatelet therapies are currently lacking.
ChemInform Abstract: SILICATE‐CONTAINING SODIUM BETA‐ALUMINA SOLID ELECTROLYTES (1978)

Abstract Nα‐β‐Al,O3‐Festelektrolyte mit bis zu 7.5 Gew.‐% SiOz werden durch ein schnelles Zonensinterverfahren bei 1750°C dargestellt und bezüglich Dichte, Na‐Gehalt, Gefüge und Ionenleitfähigkeit untersucht.
Delivery of pDNA to lung epithelial cells using PLGA nanoparticles formulated with a cell-penetrating peptide: understanding the intracellular fate (2020)

The combination of nanoparticles (NPs) and cell-penetrating peptide (CPP) represents a new opportunity to develop plasmid DNA (pDNA) delivery systems with desirable properties for lung delivery. In this study, poly(lactide-co-glycolide) (PLGA) NPs containing pDNA were formulated with and without CPP using a double-emulsion technique. NPs were characterized in regards of size, surface charge, release profile, pDNA encapsulation efficiency and pDNA integrity. Cellular uptake, intracellular trafficking, uptake mechanism and pDNA expression were assessed in both A549 and Beas-2B cells. Manufactured PLGA-NPs efficiently encapsulated pDNA with approximately 50% released in the first 24 h of incubation. Addition of CPP was essential to promote NP internalization in both cell lines, with 83.85 ± 1.2% and 96.76 ± 1.7% of Beas-2B and A549 cells, respectively, with internalized NP-DNA-CPP after 3 h of incubation. Internalization appears to occur mainly via clathrin-mediated endocytosis, with other pathways also being used by the different cell lines. An endosomal-escape mechanism seems to happen in both cell lines, and eGFP expression was observed in Beas-2B after 96 h of incubation. In summary, the NP-DNA-CPP delivery system efficiently encapsulated and protected pDNA structure and is being investigated as a promising tool for gene delivery to the lungs.