gebhart/patrepeval huggingface dataset:
Determination of arsenic in solid samples by cold acid solubilisation-hydride generation atomic absorption spectrometry (1988)

A method is described for the determination of arsenic directly from solid environmental samples by a rapid cold acid dissolution-hydride generation method incorporating atomic absorption detection. Details are given for the optimum experimental and instrumental conditions required for both solid and solution analysis. The influence of interfering elements in the sample matrix has been examined. Recoveries for the rapid dissolution method compare favourably with traditional hot acid extraction with aqua regia which commonly requires lengthy handling procedures. The method developed shows promise as a rapid screening procedure for a range of environmental sample types, being able to achieve acceptable accuracy together with precisions of the order of 7% RSD.
Meetings Diary: Electrophoresis 13/2008 (2008)

Dynamic field gradient focusing uses an electric field gradient to separate and concentrate proteins in native buffers. A prototype preparative-scale dynamic field gradient focusing apparatus reproducibly separated hemoglobin and bovine serum albumin with a mean resolution of 2.64 0.503. Run-to-run variations in the hemoglobin's focal point and peak width appeared to be related to fluctuations in the shape of the electric field, rather than the 5% accuracy of the pump that provided the counter-flow in the separation annulus. The variation in the electric field gradient was probably due to the formation and expansion of an ion-depleted region at the top of the separation annulus.
PP2Cγ: a human protein phosphatase with a unique acidic domain1 (1997)

We have cloned a novel cDNA from human skeletal muscle which encodes a protein phosphatase with a unique acidic domain. It is 34% identical to mammalian PP2C alpha and PP2C beta and we call it PP2C gamma. It more closely resembles PP2Cs from Paramecium tetraurelia and Schizosaccharomyces pombe than mammalian PP2Cs. Northern blot analysis shows that PP2C gamma is widely expressed, and is most abundant in testis, skeletal muscle, and heart. Like known PP2Cs, recombinant PP2C gamma requires Mg2+ or Mn2+ for activity. Unlike any other known phosphatase, PP2C gamma has a highly acidic domain: 75% of the 54 residues are glutamate or aspartate.
Experimental challenge and pathology of highly pathogenic avian influenza virus H5N1 in dunlin (Calidris alpina), an intercontinental migrant shorebird species (2011)

Dunlin are highly susceptible to infection with HPAIV H5N1. They become infected after exposure to relatively small doses of the virus and if they become infected, they are most likely to suffer mortality within 3-5 days. These results have important implications regarding the risks of transport and transmission of HPAIV H5N1 to North America by this species and raises questions for further investigation.
Preoperative renal insufficiency predicts postoperative adverse outcomes in a mixed surgical population: a retrospective matched cohort study using the NSQIP database (2023)

Patients with preoperative RI have an increased risk of postoperative 30-day mortality and complications. RI group patients with current dialysis, estimated glomerular filtration rate less than or equal to 30 ml/min/1.73 m 2 or concomitant anemia had an elevated risk of postoperative mortality.
MOCVD of ZrO2 and HfO2 Thin Films from Modified Monomeric Precursors (2006)

Abstract Metal‐organic precursors of Zr and Hf with excellent vaporization characteristics and low decomposition temperatures are reported. The new mixed alkoxide precursors [Zr(O t Bu) 2 (tbaoac) 2 ] (1) and [Hf(O t Bu) 2 (tbaoac) 2 ] ( 2 ) were synthesized by facile alcohol‐exchange reactions between [M(O i Pr) 2 (L) 2 ] and tert ‐butanol [M = Zr, Hf; L = tert ‐butylacetoacetate (tbaoac)]. The six‐coordinated monomeric compounds are volatile, stable in solution, and less sensitive to air and moisture compared to parent alkoxides such as [Zr(O t Bu) 4 ] and [Hf(O t Bu) 4 ]. It was possible to grow ZrO 2 and HfO 2 at low deposition temperatures, and the films were characterized by X‐ray diffraction ( XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), and Rutherford back scattering (RBS) analysis. [Zr(O t Bu) 2 (tbaoac) 2 ], evaluated in a multiwafer planetary MOCVD reactor combined with a liquid delivery system, yielded ZrO 2 films that show promise for gate oxide applications.
Distance Dependence of the Photocatalytic Efficiency of TiO2 Revealed by in Situ Ellipsometry (2012)

Spectroscopic ellipsometry was utilized to follow in situ photodegradation of organic species in the vicinity of TiO(2) nanoparticles during UV irradiation. Stacked layers composed of TiO(2), mesoporous SiO(2), and mixed mesoporous SiO(2)/TiO(2) nanocomposites with controlled thickness and porosity were used as model materials. Lauric acid molecules and poly(vinyl chloride) (PVC) layers were used as model mobile and immobile pollutants, respectively. The local photocatalytic activity was deduced by monitoring the variation of the thickness and refractive index of each independent layer. We show that the photocatalyzed degradation of an organic pollutant takes place only when the latter is located in close vicinity to the TiO(2) nanoparticle surface or can naturally diffuse toward it. As a result, the reaction efficiency is directly related to the organic pollutant diffusion. We also show that the distance of photocatalysis efficiency (d(s)) at which radical intermediates are still present and active is <10 nm from the TiO(2) surface under the conditions of the experiments. This was confirmed by the fact that an immobile condensed organic phase such as PVC was protected from the photocatalytic degradation when separated from the TiO(2) by a 20 nm layer of mesoporous silica.
Statistical analysis of process variation induced SRAM electromigration degradation (2014)

Electromigration (EM) greatly affects the long term reliability of VLSI chips. Not only power/ground (P/G) lines, but also bit-lines of SRAM arrays may be damaged by EM. In this work, we demonstrate that the EM reliability of an SRAM array can be dramatically worsened by process variation due to a significant increase of sub-threshold leakage current on the bit-line. We statistically model the effects of process variation and offer a procedure for preventing EM failure by modifying the width of bit-lines and P/G lines. Taking into account the effect of bit-line width modification on cell stability and performance, we propose a trade-off between functional and EM failures and indicate an optimal bit line width that maximizes the yield of SRAM arrays.
Role of O-linked carbohydrate chains on leukocyte cell membranes in platelet-induced leukocyte activation. (1994)

We previously reported that activated platelets stimulated neutrophils and monocytes to produce superoxide anion (O2-) through the interaction between P-selectin and its carbohydrate ligand, sialyl Lewis X (sLeX) (Nagata, K., Tsuji, T., Todoroki, N., Katagiri, Y., Tanoue, K., Yamazaki, H., Hanai N., and Irimura, T. (1993) J. Immunol. 151, 3267-3273). In the present study, we investigated the role of cell surface carbohydrate chains of leukocytes in this process. Glycoconjugate-specific hydrolytic enzymes and inhibitors of glycosylation processing were applied. Granulocyte-like differentiated HL-60 (gHL-60) cells released an increased amount of O2- in response to activated platelets in a P-selectin-dependent manner. When HL-60 cells were differentiated in the presence of benzyl-alpha-N-acetylgalactosaminide (Bzl-alpha-GalNAc), an inhibitor of chain elongation of O-linked carbohydrates, the enhanced generation of O2- was abrogated in parallel with decrease in the expression of sLex structure and in the adhesion capacity to activated platelets. In contrast, treatment with swainsonine or 1-deoxymannojirimycin, inhibitors of processing of N-linked carbohydrate chains, did not show such effects. O-Sialoglycoprotease treatment of gHL-60 cells decreased the activated platelet-induced O2- production with concomitant reduction of cell surface sLex expression. Treatment of these cells with N-glycanase did not affect the O2- production. These results strongly suggested that serine/threonine-linked carbohydrate chains containing sLex played an essential role in the P-selectin-mediated leukocyte activation. By Western blotting analysis of gHL-60 cell lysates, we identified two glycoproteins which carried sLex structures and were sensitive to Bzl-alpha-GalNAc treatment.
Preserving the Bell Towers of Venice (2019)

Our project seeks to aid in the preservation of Venetian bells and towers. Through detailed quantitative surveys of bell towers, and the creation of interactive virtual tours, we expanded the Venice Project Center’s knowledge on bells and towers in Venice. To provide a comprehensive presentation of bell tower data, we redesigned the VPC’s Bells web application using new visualization techniques with improved data management and input technologies.
ChemInform Abstract: Cooperative Heterogeneous Organocatalysis and Homogeneous Metal Catalysis for the One‐Pot Regioselective Synthesis of 2‐Pyridones. (2013)

Abstract An unprecedented formal [3 + 3]‐cyclodehydration approach leads to the synthesis of N‐alkyl and N‐arylsubstituted 2‐pyridones from β‐ketoamides and primary or secondary propargylic alcohols.
Analysis of RMS current on DC-link capacitor with single-shunt current sensing system (2015)

A single-shunt current sensing technique is widely used in industrial system to reduce the cost and mounting space of current sensors in an inverter. In addition, a pulse shift control technique, which maintains the pulse duration and achieves reliable current detection, is used in a single-shunt current sensing system. In this paper, the RMS current on the DC-link capacitor with a pulse shift control technique was analyzed. The analysis results showed that the RMS current on the DC-link capacitor in the single-shunt current sensing system increases over 50% compared to a conventional three-phase current sensing system, in case of a low modulation factor. In addition, the rise in temperature of the DC-link capacitor with or without the single-shunt current sensing was verified by examination. An advanced single-shunt current sensing technique for a redundant inverter system to reduce the RMS current on the DC-link capacitor and the audible noise is also proposed in this paper.
Supplementary Data from Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis (2023)

&lt;p&gt;Supplemental tables 1-10.&lt;/p&gt;
Incorporating Sustainability Considerations into the Transportation Asset Management Process (2009)

The strategic, network and project-level decisions supported by transportation infrastructure asset management have many technical, economic, social and environmental impacts over the life-cycle of the transportation infrastructure. The assessment of these impacts over the whole life of the infrastructure systems is necessary for making informed decisions on how to define policies, allocate resources, select projects, and/or design and construct these projects in a sustainable manner. The paper proposes that the approach to evaluate potential transportation projects, programs and strategic plans on the basis of a combination of engineering and economic criteria is no longer sufficient if decision makers want to assure the long-term sustainability of transportation systems. To support sustainable development, transportation asset management decisions should be constructed over three pillars: economic development, ecological sustainability, and social desirability. The assessment of these three aspects has been placed under the umbrella of life-cycle management. Current practice typically includes the consideration of technical and economic issues through life cycle cost analysis (LCCA). Environmental aspects are increasingly being considered though life cycle assessment (LCA) and although the inclusion of social aspects is in its infancy, they should not be neglected. The consideration of environmental and social goals in conjunction with economic considerations promises to enhance transportation infrastructure asset management while promoting sustainable transportation infrastructure systems.
Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury (2007)

Oxidized low-density lipoproteins (oxLDL) and their scavenger receptor (SR) binding partners play a central role in atherosclerosis and by analogy may play a role in chronic kidney disease pathogenesis. The present study was designed to investigate in C57BL/6 mice the effects of hypercholesterolemia on renal injury severity and oxLDL generation after unilateral ureteral obstruction (UUO). The expression profiles of CD36, SR class AI/II (SR-A), lectin-like receptor for oxidized low-density lipoprotein-1 (Lox-1), and SR that binds phosphatidylserine and oxLDL (SR-PSOX/CXCL16) were examined. Four experimental groups were studied: sham and UUO male mice on either a high-fat Western diet or a control diet. Significantly more oxLDL accumulated in the tubulointerstitium of hypercholesterolemic mice compared with normocholesterolemic mice after 14 days of UUO (P < 0.01). Total kidney collagen was significantly higher in the obstructed kidneys of hypercholesterolemic mice compared with normocholesterolemic mice on day 14 (P < 0.01). After 14 days of obstruction, the number of interstitial F4/80+ macrophages and NF-kappaB activation increased in hypercholesterolemic mice compared with normocholesterolemic mice (P < 0.01). In normal kidneys, CD36, SR-A, Lox-1, and CXCL16 were primarily localized to renal tubular epithelia. After ureteral obstruction, CD36 increased at day 7; SR-A and Lox-1 progressively decreased in a time-dependent manner; and CXCL16 increased significantly with the onset of obstruction (P < 0.01). Strong tubular expression suggests that in addition to inflammatory interstitial cells, renal tubular scavenger receptors may help to orchestrate the inflammatory and fibrogenic pathways that are activated by oxLDL.
Abstract 3012: Development of a microRNA signature for risk of progression in renal cell carcinoma (2010)

Abstract The incidence of asymptomatic pathologically localized renal cell carcinoma (RCC) has shown the greatest increase in recent decades. Despite the finding of organ-confined (pT1 or T2) disease at the time of nephrectomy, a subset of patients will have local recurrence or distant metastasis after nephrectomy. Most solid neoplasms are now thought to accumulate a series of genetic and epigenetic changes as they progress through well-defined clinical and histopathological changes. The association of particular molecular markers with progression and outcome of disease means that the status of certain markers can be used to identify the presence of disease and its likelihood for progression. To identify an epigenetic signature that may predict recurrence in patients with organ-confined RCC, we examined RNA hybridized to the Agilent microRNA (miRNA) array from a large number (&amp;gt;100) of RCC patients with extensive clinicopathological annotation. The potential of miRNAs as biomarkers for risk of progression and early detection of recurrent RCC has not yet been studied. Since approximately 90% of metastatic RCC is of clear cell histology, we examined only this histological cell type. The cell type and grade of the RCC was re-reviewed blind by a single pathologist. miRNA expression signatures were established from a series of low grade (I-II), low stage (pT1-2) clear cell RCC with no evidence of disease after nephrectomy for at least 5 years; a series of high grade, high stage (pT3-4), clear cell RCC; and a series of low grade and low stage clear cell RCC that progressed. The expression of particular miRNAs was validated by qRT-PCR. In the growing number of patients who have undergone surgical resection for organ-confined RCC, the near term goal would be to identify those that should be followed more closely and a future goal, depending upon results of ongoing therapeutic trials, to be directed to adjuvant therapy. There would also be cost benefits in potentially following those RCC patients with lowest risk of progression less frequently. MiRNA signatures obtained by our study will address the clinical question whether risk of progression could be defined in patients with organ-confined RCC at initial surgery. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3012.
Polygonalization of mm-wave dual-band circular phased arrays for multi-mode beamforming (2018)

The modularization of 28 GHz multi-mode circular arrays and 60 GHz phased sub-arrays onto N-sided convex polygons is presented. This includes a study on the basic impact of phase error arising from this mapping and the achievable radiation performance from both bands. The intent of this mapping is to investigate the manufacturability and modularization of dual-band mm-wave phased arrays operating at 28 GHz and 60 GHz. The faceted 28 GHz design is operated as a non-uniform multi-mode array, where the polygon is used to approximate the ideal uniform circular array. This gives rise to a subarray concept for a multi-band (or wide band) antenna that operates as a traditional phased array panel in this architecture. In this work, we constrain the resulting design space to provide an approximation of uniform spacing based on the geometric parameterization of the structure for half-wave spacing in the 28 GHz band. The basic layout of the design is presented first and constrained to examine the error arising from modularization. A wavelength-scaled prototype operating at 2.4 GHz is used to demonstrate the measurement and error of the system.
Time-resolved Fluorescence Decay Analysis of Photoresist Film by GaN LD Pumped Single-Photon Counting Method (2007)

In order to study photoinitiating mechanism of photochemically initiated radical polymerization in thick negative photoresist, fluorescence lifetime analyses of dry film photoresist were conducted by gallium nitride semiconducter laser pumped single-photon counting method. Lifetimes of photosensitizers, 4-methyl-7-(N,N-diethyl)aminocoumarin (C1), 4,4'-(N,N,N',N'-tetraethy)aminobenzophenon (EAB), 1-phenyl -3-[2-(4''-t-butylphenyl)vinyl]-5-(4'''-t-butyl) phenylpyrazoline (Pyraz) or 9,10-di-n-butoxyanthracene in film resists with and without photoinitiator, 2,2'-bis (σ-methylphenyl)-4,4',5,5'-tetraphenyl- imidazole (Me-HABI), as a quencher were successfully obtained. Quenching efficiencies, η, defined as 1-(τ/τ0), were compared with photoinitiaing efficiencies which were obtained by RT-FTIR measurement of double bond disappearance and photospeed determined by gray scale step method. From correlation between quenching efficiencies and photoinitiating efficiencies in an extent, it was elucidated that the singlet excited state of photosensitizer seems to involve in the photoinitiation process as an important process.
Pyridine‐Containing Electron‐Transport Materials for Highly Efficient Blue Phosphorescent OLEDs with Ultralow Operating Voltage and Reduced Efficiency Roll‐Off (2014)

A series of pyridine‐containing electron‐transport materials are developed as an electron‐transport layer for the FIrpic‐based blue phosphorescent organic light‐emitting diodes. Their energy levels can be tuned by the introduction of pyridine rings in the framework and on the periphery of the molecules. Significantly reduced operating voltage is achieved without compromising external quantum efficiency by solely tuning the nitrogen atom orientations of those pyidine rings. Unprecedented low operating voltages of 2.61 and 3.03 V are realized at 1 and 100 cd m −2 , giving ever highest power efficiency values of 65.8 and 59.7 lm W −1 , respectively. In addition, the operating voltages at 100 cd m −2 can be further reduced to 2.70 V by using a host material with a small singlet‐triplet exchange energy, and the threshold voltage for electroluminescence can even be 0.2–0.3 V lower than the theoretical minimum value of the photon energy divided by electron charge. Aside from the reduced operating voltage, a further reduced roll‐off in efficiency is also achieved by the combination of an appropriate host material.
Model for macroevolutionary dynamics (2013)

The highly skewed distribution of species among genera, although challenging to macroevolutionists, provides an opportunity to understand the dynamics of diversification, including species formation, extinction, and morphological evolution. Early models were based on either the work by Yule [Yule GU (1925) Philos Trans R Soc Lond B Biol Sci 213:21-87], which neglects extinction, or a simple birth-death (speciation-extinction) process. Here, we extend the more recent development of a generic, neutral speciation-extinction (of species)-origination (of genera; SEO) model for macroevolutionary dynamics of taxon diversification. Simulations show that deviations from the homogeneity assumptions in the model can be detected in species-per-genus distributions. The SEO model fits observed species-per-genus distributions well for class-to-kingdom-sized taxonomic groups. The model's predictions for the appearance times (the time of the first existing species) of the taxonomic groups also approximately match estimates based on molecular inference and fossil records. Unlike estimates based on analyses of phylogenetic reconstruction, fitted extinction rates for large clades are close to speciation rates, consistent with high rates of species turnover and the relatively slow change in diversity observed in the fossil record. Finally, the SEO model generally supports the consistency of generic boundaries based on morphological differences between species and provides a comparator for rates of lineage splitting and morphological evolution.
LHRH et agonistes (1985)

LHRH et agonistes :La synthèse d'agonistes puissants de la LHRH (luteinizing hormone releasing hormone), hormone hypothalamique qui contrôle la sécrétion des gonadotrophines hypophysaires, a conduit rapidement à de multiples applications cliniques dans différents domaines : du traitement de l'infertilité à la contraception, du traitement du cancer de la prostate à celui de la puberté précoce et de l'endométriose.
Figure S1 from <i>EGFR</i> and <i>MET</i> Amplifications Determine Response to HER2 Inhibition in <i>ERBB2</i>-Amplified Esophagogastric Cancer (2023)

&lt;p&gt;Additional results for dual probe EGFR and ERBB2 FISH from Patients 9, 30 and 32.&lt;/p&gt;
Experimental validation of pulse contour methods for estimating stroke volume at pacing onset (2002)

Stroke volume (SV) might be an important variable in assessing cardiac function of patients under pacing therapy. To assess the accuracy of estimating SV changes from aortic pressure during VDD pacing, we implanted electromagnetic flowmeters in the aortic root of five mongrel dogs. Three pacing sites, including right ventricle, left ventricle and both ventricles were selected and paced at 5 atrioventricular delays. Each pacing site/AV delay combination was repeated 5 times in a randomized order. The protocol alternated 5 paced beats and 15 intrinsic beats. Flow and aortic pressure data were recorded and analyzed. We evaluated five pulse contour equations relating pulse pressure (PP), ejection time (ET), diastolic time (DT) and aortic pressure area during systole over the end-diastolic pressure (Psa). A good correlation (r=0.84-0.89) was shown between percent change in SV and percent change in PP, PP*ET, Psa, Psa*ET and Psa*(1+ET/DT) over the preceding baseline. The average estimated percent change in SV also correlated with the average measured percent change in SV for each pacing site/AV delay combination. In conclusion, PP, PP*ET, Psa, Psa*ET and Psa*(1+ET/DT) may be clinically applicable for assessing SV at the start of VDD pacing and may effectively predict the effects of pacing sites and AV delays on SV.