gebhart/patrepeval huggingface dataset:
Predicting computer system failures using support vector machines (2008)

Mitigating the impact of computer failure is possible if accurate failure predictions are provided. Resources, applications, and services can be scheduled around predicted failure and limit the impact. Such strategies are especially important for multi-computer systems, such as compute clusters, that experience a higher rate failure due to the large number of components. However providing accurate predictions with sufficient lead time remains a challenging problem.

This paper describes a new spectrum-kernel Support Vector Machine (SVM) approach to predict failure events based on system log files. These files containmessages that represent a change of system state. While a single message in the file may not be sufficient for predicting failure, a sequence or pattern of messages may be. The approach described in this paper will use a sliding window (sub-sequence) of messages to predict the likelihood of failure. The a frequency representation of the message sub-sequences observed are then used as input to the SVM. The SVM then associates the messages to a class of failed or non-failed system. Experimental results using actual system log files from a Linux-based compute cluster indicate the proposed spectrum-kernel SVM approach has promise and can predict hard disk failure with an accuracy of 73% two days in advance.
ChemInform Abstract: Polyfluorinated Aryl Azides as Photoaffinity‐Labelling Reagents. The Room Temperature CH Insertion Reactions of Singlet Pentafluorophenylnitrene with Alkanes. (1989)

Abstract The nitrene, photochemically‐generated from pentafluorophenyl azide (I), reacts with cyclopentane (II) to yield the cyclopentylaniline (III).
Earth Mover Distance on superpixels (2010)

Earth Mover Distance (EMD) is a popular distance to compute distances between Probability Density Functions (PDFs). It has been successfully applied in a wide selection of problems of image processing. This success comes from two reasons, a physical one, since it computes a physical cost to transport an element of mass between two images or two histograms, and a statistical one, since it is a cross-bin metric (as opposed to a bin-wise metric). In computer vision, these features are useful since small variation of illuminance can shift the histogram. However, histograms are not a sufficient statistic to discriminate images since they ignore all geometric correlations. In addition, transport also called flow of an histogram loose the information of geometric flow to warp one image on to an other. This paper proposes a new construction of EMD between images. This construction approximates the EMD between two images, by computing a pixel-wise transport at the complexity cost of computing an EMD between 1-D Histograms and preserves the geometrical and topological structure of the image. This construction simply relies on a segmentation of the image (also called superpixelization of the image). Results on matching on images shows the stability of the method even when the superpixelizations are highly inconsistent across images.
Mode- and wavelength-division multiplexed transmission using all-fiber mode multiplexer based on mode selective couplers (2015)

We propose all-fiber mode multiplexer composed of two consecutive LP₁₁ mode selective couplers that allows for the multiplexing of LP₀₁ mode and two-fold degenerate LP₁₁ modes. We demonstrate WDM transmission of 32 wavelength channels with 100 GHz spacing, each carrying 3 modes of 120 Gb/s polarization division multiplexed quadrature phase shifted keying (PDM-QPSK) signal, over 560 km of few-mode fiber (FMF). Long distance transmission is achieved by 6×6 multiple-input multiple-output digital signal processing and modal differential group delay compensated link of FMF. The all-fiber mode multiplexer has considerable potential to be used in mode- and wavelength-division multiplexed transmission.
Photodetachment of Positronium Negative Ions (2011)

Photodetachment of the positronium negative ion, a bound state of one positron and two electrons, has been observed. Development of a method to produce the ions efficiently using a Na coated tungsten surface has enabled the first observation of the photodetachment. The obtained lower limit of the photodetachment cross section for the wavelength of 1064 nm is consistent with the theoretical calculations reported so far. The experimental field developed in the present work gives new opportunities to explore the quantum mechanical three-body problem and to develop energy-tunable positronium beams.
Advanced prostate cancer: an update. (2000)

A number of therapeutic options are available or on the horizon for patients for whom initial treatment of localized prostate cancer has failed. Currently under study are time of therapy, maximum androgen blockade, and palliative and adjunctive therapies.
Gate-all-around MOSFETs based on vertically stacked horizontal Si nanowires in a replacement metal gate process on bulk Si substrates (2016)

We report on gate-all-around (GAA) n- and p-MOSFETs made of 8-nm-diameter vertically stacked horizontal Si nanowires (NWs). We show that these devices, which were fabricated on bulk Si substrates using an industry-relevant replacement metal gate (RMG) process, have excellent short-channel characteristics (SS = 65 mV/dec, DIBL = 42 mV/V for L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">G</sub> = 24 nm) at performance levels comparable to finFET reference devices. The parasitic channels below the Si NWs were effectively suppressed by ground plane (GP) engineering.
Ultrasound analysis of the uterine wall movement for improved electrohysterographic measurement and modeling (2013)

During pregnancy, analysis of the electrohysterogram (EHG), which measures the uterine electrical activity, can provide a fundamental contribution for the assessment of uterine contractions and the diagnosis of preterm labor. However, several aspects concerning uterine physiology and its link with EHG measurements are still unclear. As a consequence, the EHG is not yet part of the clinical practice. There is general consensus that modeling and analysis of the EHG can be improved only by understanding and integrating the main properties of the uterine physiology at different levels, e:g:, cellular, tissue, and organ, and of different nature, e:g:, electrical, mechanical, and structural. In this study, we use transabdominal ultrasound (US) measurements to investigate the mechanical changes that the uterus undergoes during pregnancy under the effect of contractions. We refer to this measurement as mechanohysterogram. Analysis of the mechanohysterogram highlights, for the first time, two phenomena that can influence EHG signal interpretation, namely, changes in uterine wall thickness during contractions and respiration-induced uterine wall movements. Our results suggest that these phenomena can affect the interpretation of the EHG and should therefore be taken into account for accurate modeling and assessment of the uterine electrical activity.
An adaptive resonance neural network implementation utilizing phase conjugation (1992)

A novel adaptive resonance (ART) device, based on holographic information processing in a phase-conjugating crystal, allows pattern retrieval in a resonating loop utilizing angle-multiplexed reference beams. A reset mechanism allows an ART search strategy by rejecting beams as needed. The design is inspired by a non-learning optical associative memory, the holographic optical resonator, 1 but does learn and uses information the other device discards. The learning capability results from replacing the resonator’s fixed hologram with a barium titanate crystal. This device offers higher information storage density than do alternative ART implementations. 2-5
<title>Quantitative Doppler ultrasound-based determination of volumetric blood flow</title> (2002)

Conventional ultrasound Doppler velocity measurements are scaled by the cosine of the angle between the blood flow axis and ultrasound beam axis. In the approach used here, a transducer array was used to acquire a first cross-sectional Doppler data set of the vessel under examination. The transducer array was then moved to a different angle to acquire a second cross-sectional Doppler data set. Thereafter, we used the known angle between the two arrays ultrasound beams and the cosine (theta) scaled Doppler estimates to solve for the true angle between the blood flow axis and ultrasound beam axis of the first data set. Upon integrating the angle corrected velocity estimates over the entire vessel cross-section, we were able to estimate blood volume flow rate. The performance of the new approach was tested in a flow phantom that was designed to provide a constant flow in a simulated vessel. The data were collected for two sets of angles and three different flow velocities for each angle set. The unknown Doppler angle was calculated from the data and used to correct the flow velocity.
PON as a driver for optical components (2007)

This paper considers how passive optical networks (PONs) will act as a driver for optical components. The background and current status of PON systems and standards are presented, and a discussion of key technology areas is presented.
Impact of acoustic pressure on autoignition and heat release (2014)

A feedback mechanism for thermoacoustic pulsations in gas turbine reheat combustors is proposed and investigated, namely the impact of acoustic pressure waves on the reaction kinetics of autoignition. An analytical model framework is developed, which represents the combustor as a plug flow reactor. This analogy allows one to derive modulations of the heat release rate as a result of the history of pressure perturbations during the autoignition process. Numerical studies are conducted on homogeneous reactors with detailed chemistry simulations, in order to assess quantitatively the pressure sensitivity of the reaction kinetics of autoignition. From such sensitivities, flame transfer functions of autoignition flames are derived. The expressions obtained are successfully compared with time-domain simulations in one-dimensional space, and used in acoustic network models for stability predictions. The wider applicability of the model is demonstrated by extending it to nonlinear dynamics, transverse modes and technical premix conditions. The results obtained indicate that in general the feedback mechanism results in a positive contribution to the acoustic source term, in particular at elevated frequencies.
Enhancing Potentiometric Response of Electrochemical Sensor Using Modified Ion-Sensitive Transistor (2019)

In this work, we present a novel combination of solid-state ion-selective electrode and field effect transistor (FET) integrated on same platform. Thus, creating an extended gate field effect transistor (EGFET). We have built an electrochemical sensing unit comprised of all solid-state electrodes, an Ag/AgCl reference electrode and ionophore coated gold electrode. Unlike any of the earlier reports, all the electrodes are integrated with a FET in a single plane of the printed circuit board (PCB), hence mitigating the issues of separate wire bonding or external connection between the sensing element and the transducer by using PCB traces. In this work, we demonstrate for the first time, the use of ion sensitive electrode (ISE) in EGFET configuration without degrading the linearity and sensitivity due to the external voltage bias. Potentiometric measurement on our K + ISE shows near Nernstian limit sensitivity (49 mV/decade), low concentration for the limit of detection (10 −6 M), and linearity over a large range of detection(10 −4 M to 1 M).
Spin–torque dynamics for noise reduction in vortex-based sensors (2021)

The performance of magnetoresistive sensors is today mainly limited by their 1/f low-frequency noise. Here, we study this noise component in vortex-based TMR sensors. We compare the noise level in different magnetization configurations of the device, i.e., vortex state or uniform parallel or antiparallel states. We find that the vortex state is at least an order of magnitude noisier than the uniform states. Nevertheless, by activating the spin-transfer-induced dynamics of the vortex configuration, we observe a reduction of the 1/f noise, close to the values measured in the AP state, as the vortex core has a lower probability of pinning into defect sites. Additionally, by driving the dynamics of the vortex core by a non-resonant rf field or current, we demonstrate that the 1/f noise can be further decreased. The ability to reduce the 1/f low-frequency noise in vortex-based devices by leveraging their spin-transfer dynamics thus enhances their applicability in the magnetic sensors' landscape.
Pharmacodynamics, pharmacokinetics and safety of multiple ascending doses of the novel dual glucose‐dependent insulinotropic polypeptide/glucagon‐like peptide‐1 agonist RG 7697 in people with type 2 diabetes mellitus (2017)

Daily doses of RG7697 for 2 weeks were well tolerated by the majority of patients with T2D. Pharmacokinetic data supported once-daily dosing and pharmacodynamic effect displayed dose-dependent reductions in fasting and postprandial plasma glucose, without increasing the risk of hypoglycaemia.
Quantitative technique for robust and noise-tolerant speed measurements based on speckle decorrelation in optical coherence tomography (2014)

Intensity-based techniques in optical coherence tomography (OCT), such as those based on speckle decorrelation, have attracted great interest for biomedical and industrial applications requiring speed or flow information. In this work we present a rigorous analysis of the effects of noise on speckle decorrelation, demonstrate that these effects frustrate accurate speed quantitation, and propose new techniques that achieve quantitative and repeatable measurements. First, we derive the effect of background noise on the speckle autocorrelation function, finding two detrimental effects of noise. We propose a new autocorrelation function that is immune to the main effect of background noise and permits quantitative measurements at high and moderate signal-to-noise ratios. At the same time, this autocorrelation function is able to provide motion contrast information that accurately identifies areas with movement, similar to speckle variance techniques. In order to extend the SNR range, we quantify and model the second effect of background noise on the autocorrelation function through a calibration. By obtaining an explicit expression for the decorrelation time as a function of speed and diffusion, we show how to use our autocorrelation function and noise calibration to measure a flowing liquid. We obtain accurate results, which are validated by Doppler OCT, and demonstrate a very high dynamic range (> 600 mm/s) compared to that of Doppler OCT (±25 mm/s). We also derive the behavior for low flows, and show that there is an inherent non-linearity in speed measurements in the presence of diffusion due to statistical fluctuations of speckle. Our technique allows quantitative and robust measurements of speeds using OCT, and this work delimits precisely the conditions in which it is accurate.
Estramustine binding protein (EMBP) in rat R3327 dunning tumors: Partial characterization and effect of hormonal withdrawal, hormonal replacement, and cytotoxic treatment on its expression (1991)

Expression of estramustine-binding protein (EMBP) was determined in eight variants of the Dunning R3327 rat prostate adenocarcinoma. This secretory protein was previously isolated from the normal rat prostate and binds estramustine and estromustine, the metabolites exerting anti-mitotic and anti-proliferative activity of the anticancer agent estramustine phosphate (EstracytR). EMBP was found in relatively high amounts only in the androgen-responsive G and H tumors from intact hosts, whereas low (AT-1, HI-F) or nondetectable levels (HI-S, AT-3, MAT-LyLu, MAT-Lu) were obtained in the androgen-independent tumors. Castration decreased EMBP expression in both G and H tumors, as did estradiol and estramustine when given separately to intact rats. Supplementation of castrates with exogenous androgen stimulated EMBP expression above the pre-castration level and was further enhanced when combined with estradiol and in particular estramustine. Partial physicochemical characterization of EMBP in G and H tumors was performed by using ligand-based and immunoblotting techniques. [3H]Estromustine was bound to cytosols and salt extracts from tumors with the same affinity and displayed similar surface-charge distribution, sedimentation behavior, and subunit composition as found for ventral and dorsolateral prostatic tissue from tumor-bearing rats. This study indicates that the synthesis of EMBP is under androgenic control and that its expression may be correlated to androgen responsiveness, metastatic potential, and androgen receptor content but not to growth rate and morphology of the tumors. EMBP may therefore provide a mechanism for concentration of cytotoxic activity at the target site in EMBP-positive tumors and help in the evaluation of antitumor effects obtained when administering estramustine.
Triangular Elastomeric Stamps for Optical Applications: Near‐Field Phase Shift Photolithography, 3D Proximity Field Patterning, Embossed Antireflective Coatings, and SERS Sensing (2012)

Abstract The use of a decal transfer lithography technique to fabricate elastomeric stamps with triangular cross‐sections, specifically triangular prisms and cones, is described. These stamps are used in demonstrations for several prototypical optical applications, including the fabrication of multiheight 3D photoresist patterns with near zero‐width features using near‐field phase shift lithography, fabrication of periodic porous polymer structures by maskless proximity field nanopatterning, embossing thin‐film antireflection coatings for improved device performance, and efficient fabrication of substrates for surface‐enhanced Raman spectroscopic sensing. The applications illustrate the utility of the triangular poly(dimethylsiloxane) decals for a wide variety of optics‐centric applications, particularly those that exploit the ability of the designed geometries and materials combinations to manipulate light–matter interactions in a predictable and controllable manner.
An oscillation-based test structure for timing information extraction (2012)

Technology scaling introduces many sources of variability and uncertainty that are difficult to model and predict [3]. The result of these uncertainties is a degradation in our ability to predict the performance of fabricated chips, i.e., a lack of model-to-hardware matching. The prediction of circuit performance is the result of a complex hierarchy of models starting at the basic MOSFET device model and rising to full-chip models of important performance metrics like power, frequency of operation, etc. The assessment of the quality of such models is an important activity, but it is becoming harder and more complex with rising levels of variability, as well as with the increase in the number of systematic effects observed in modern CMOS processes. The purpose of this paper is to introduce a special-purpose test structure that specifically focuses on ensuring the accuracy of gate timing models. The certification of digital design correctness (the so-called signoff) is based largely on the results of performing a Static Timing Analysis (STA) [15], [18], which, in turn, is based entirely on the gate timing models. Our test structure compares favorably to alternative approaches; it is far easier to obtain the desired results than direct delay measurement, and it is much more general than simple ring oscillator structures. Further, the structure is specified at a high level, allowing it to be synthesized using a standard ASIC place-and-route flow, thus capturing the systematic local layout effects which can sometimes be lost by simpler (e.g., ring oscillator) structures. Experimental results show the structure can play an important role in identifying mismatches between timing models and observed hardware.
Scintillation and photoluminescence properties of Cs 2 NaY 1− x Pr x Cl 6 crystals (2020)

Abstract Herein, Cs 2 NaY 1− x Pr x Cl 6 crystalline scintillators have newly been fabricated and characterized. The crystals exhibited emission bands at ∼300 and ∼500 nm, which originated from the 5d–4f and 4f–4f transitions of Pr 3+ ions, respectively, and the scintillation decay time constants were 19–29 and 170–370 ns, respectively. The former was attributed to the emissions from the 5d–4f transitions of Pr 3+ ions, whereas the latter was attributed to the host materials. The light yields of these crystals were higher than those of undoped Cs 2 NaYCl 6 crystals. The Cs 2 NaY 0.4 Pr 0.6 Cl 6 crystal exhibited the highest light yield (7100 photons MeV −1 ), which is approximately four times higher than that of the undoped Cs 2 NaYCl 6 crystal (1800 photons MeV −1 ).
Hybrid 320 Ton Off Highway Haul Truck: Quarterly Technical Status Report 2, DOE/AL68080-TSR02 (2003)

The hybrid OHV Energy Storage System concept was defined to be a mix of two energy storage technologies. The energy management system hardware configuration was identified, based on available GE Transportation Systems hardware. The subscale demonstration energy management system protection, performance, and sequencing requirements have been specified. A set of hybrid energy management strategies has been developed.
Cytotoxic effects toward human hematopoietic progenitor cells and tumor cell lines of paclitaxel, docetaxel, and newly developed analogues IDN5109, IDN5111, and IDN5127. (1999)

The growth inhibitory effect of paclitaxel, docetaxel, and newly developed taxanes IDN5109, IDN5111, and IDN5127 was assessed on peripheral blood (PB) CD34+ maintained in liquid culture and on three human cancer cell lines (MDA-MB231, MCF-7 ADRr, CEM VBLr). Concomitantly, DNA analysis was also performed. For unfractionated peripheral blood progenitor cells (PBPC) toxicity was also assessed by clonogenic assay. The cytotoxic effects induced by taxanes toward PBPC as measured by clonogenic assay were correlated with those found for multidrug resistance (MDR)-positive cell lines (IDN5109 > IDN5111 > IDN5127 > docetaxel > paclitaxel). We established a therapeutic index (TI) between the antitumor activity in MDR-positive cells and the toxicity toward PBPC. Paclitaxel and IDN5109, as determined by TI, showed the best value in MDR-negative and MDR-positive cells, respectively. The ranking of the cytotoxic effects observed in PB CD34+ was not correlated with that obtained in clonogenic assay and in cancer cells (IDN5127 > IDN5109 > docetaxel > IDN5111). Remarkably, in DNA analysis docetaxel induced the maximal cell cycle blocking activity. Newly developed taxanes IDN5109 and IDN5111 are endowed of a profile of anticancer activity in MDR-bearing cells and toxicity toward hematopoietic progenitors better than that of docetaxel. However, mechanism(s) underlying toxicity toward hematopoietic progenitors could be, at least in part, different from that of docetaxel and likely dependent on the interaction with P-glycoprotein function in PB CD34+ cells.
Apolipoprotein E gene and sporadic frontal lobe dementia (1997)

The apolipoprotein E gene has been associated with various types of dementia. We studied the connection between the APOE gene and the risk and onset of disease in 34 patients with clinically diagnosed frontal lobe dementia (FLD) derived from a population-based study in the Netherlands. A significant increased risk of FLD (odds ratio, 4.9; 95% CI, 1.1-20.1) was found for the apoE4E4 genotype when adjusting for age, sex, and family history of dementia other than FLD. The age at onset of the disease decreased as the number of APOE*4 alleles increased. Our population-based study suggests that persons who are homozygous for the APOE*4 allele are at increased risk for developing FLD.