gebhart/patrepeval huggingface dataset:
Mapping clusters of galaxies with a stratospheric balloon experimentMapping Clusters of Galaxies with a Stratospheric Balloon Experiment. (2007)

We describe the scientific rationale and the preliminary calibrations of the OLIMPO experiment: a 2.6 m stratospheric balloon borne telescope, to be flown in 2008 in a long duration circumpolar flight. One of the main goals of the experiment is to map with high sensitivity and resolution at mm and submm wavelengths the Sunyaev-Zel’dovich effect in many clusters of galaxies, both in the Northern and in the Southern hemisphere.
Characterization of Spontaneous Mutation in the ΔsoxR and SoxS Overproducing Strains of Escherichia coli (2002)

To examine the role of the soxRS regulon in mutagenesis, we characterized the spontaneous mutations occurring in the endogenous tonB gene in the delta soxR strain and the SoxS overproducing strain of Escherichia coli. Neither the delta soxR strain nor the SoxS overproducing strain led to an enhancement or diminishment of the spontaneous mutation frequency. By DNA sequencing, we determined 50 spontaneous mutants from the delta soxR strains, and found that 36% were both base substitutions and IS insertions, 14% frameshifts and 10% deletions. Among the base substitutions, G:C-->T:A transversions and G:C-->A:T transitions predominated, followed by A:T-->T:A transversions. We determined 54 spontaneous mutants from the SoxS overproducing strains, and found that 37% were IS insertions, 31% base substitutions, 17% frameshifts, 9% deletions and 6% duplications. Among the base substitutions, G:C-->T:A transversions dominated, followed by A:T-->T:A transversions and G:C-->A:T transitions. These results were similar to those from the soxRS+ strains. Thus, it is suggested that the soxRS-regulated genes do not play a significant role in the defense against spontaneous mutagenesis.
Three-dimensional photolithography based on image reversal (2004)

In this paper we present a novel fabrication method for the realization of complex 3D multi-layer structures with commercially available photoresists. This method is based on the observation that during an image-reversal process, the post exposure bake (PEB) that is used to reverse the contrast of the exposed pattern reduces the sensitivity of the unexposed photoresist at the same time. In multi-layer lithography, this phenomenon, along with non-uniformly distributed dose can be exploited to eliminate the re-patterning effect of the subsequent exposures and thus makes suspended 3D structures possible. In this presentation we demonstrate this observation experimentally, and fabricate “woodpile” structures (&ge; 3 layers) using the proposed method.
A Genetic Porcine Model of Cancer (2015)

The large size of the pig and its similarity in anatomy, physiology, metabolism, and genetics to humans make it an ideal platform to develop a genetically defined, large animal model of cancer. To this end, we created a transgenic "oncopig" line encoding Cre recombinase inducible porcine transgenes encoding KRASG12D and TP53R167H, which represent a commonly mutated oncogene and tumor suppressor in human cancers, respectively. Treatment of cells derived from these oncopigs with the adenovirus encoding Cre (AdCre) led to KRASG12D and TP53R167H expression, which rendered the cells transformed in culture and tumorigenic when engrafted into immunocompromised mice. Finally, injection of AdCre directly into these oncopigs led to the rapid and reproducible tumor development of mesenchymal origin. Transgenic animals receiving AdGFP (green fluorescent protein) did not have any tumor mass formation or altered histopathology. This oncopig line could thus serve as a genetically malleable model for potentially a wide spectrum of cancers, while controlling for temporal or spatial genesis, which should prove invaluable to studies previously hampered by the lack of a large animal model of cancer.
Genetic background of high blood pressure is associated with reduced mortality in premature neonates (2019)

Our study provides first evidence that a genetic background of high blood pressure may be beneficial with regard to survival of preterm infants.
A Planning Tool for Improved Emergency Response (2005)

Various types of emergencies including terrorism are concerns for the safety and security of people and property on transportation systems. The Emergency Response Manual (ERM) is a tool to assist transportation agencies with pre-incident planning, emergency response training, and as a reference during emergencies. This paper discusses the applications of ERM for transportation agencies.
The Role of Mesothelin in Tumor Progression and Targeted Therapy (2013)

Mesothelin, a glycosylphosphatidylinositol (GPI) anchored cell surface protein, is a potential target for antibody-based cancer therapy due to its high expression in mesothelioma, ovarian cancer, pancreatic cancer, cholangiocarcinoma and other cancers. The SS1P immunotoxin and MORAb-009 (amatuximab), a chimeric monoclonal antibody, are currently being evaluated in clinical trials. In this review, we discuss the role of mesothelin in cancer progression and provide new insights into mesothelin-targeted cancer therapy. Recent studies highlight three mechanisms by which mesothelin plays a role in cancer progression. First, mesothelin may aid in the peritoneal implantation and metastasis of tumors through its interaction with mucin MUC16 (also known as CA125). Second, mesothelin may promote cancer cell survival and proliferation via the NF-κB signaling pathway. Finally, mesothelin expression promotes resistance to certain chemotherapy drugs such as TNF-α, paclitaxel, and a combination of platinum and cyclophosphamide. However, its cancerspecific expression makes mesothelin a potential target for monoclonal antibody therapy. New human monoclonal antibodies targeting mesothelin have been isolated by phage display technology and may provide opportunities for novel cancer therapy.
Synthesis of cyclic adenosine 5′-diphosphate ribose analogues: a C2′ endo/syn “southern” ribose conformation underlies activity at the sea urchin cADPR receptor (2010)

Novel 8-substituted base and sugar-modified analogues of the Ca(2+) mobilizing second messenger cyclic adenosine 5'-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformational analysis investigated by (1)H NMR spectroscopy revealed that a C2'endo/syn conformation of the "southern" ribose is crucial for agonist or antagonist activity at the SUH-, but not at the T cell-cADPR receptor.
Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors (2011)

Structure-activity relationship translation offers an expeditious means for discovery of new active series. This approach was applied to discover tetrahydroisoquinoline (THIQ)-based steroidomimetic microtubule disruptors. The two A-ring elements of a three-point steroidal pharmacophore were incorporated into a THIQ-based A,B-ring mimic to which an H-bond acceptor was attached as the third motif. Optimization of the representative 6c through conformational biasing delivered a 10-fold gain in activity and a new series of microtubule disruptors (e.g., 9c) with antiproliferative activity in the nanomolar range. The THIQ derivatives match, or surpass, the activities of the steroidal series and exhibit improved physicochemical properties.
Near-Field Optics Imaging in Silica Waveguide Using Near-Field Scanning Optical Microscope (2007)

We investigated the near-field optics imaging by a numerical method using special spherical chains created in a silica waveguide (SWG) and explored the possibility of how this can be used for near-field scanning optical microscopy (NSOM) applications. There are two types of spherical nanochain; type A includes nano-dielectric spheres connected closely, and type B includes silver nanoparticles 4 nm in diameter randomly distributed inside the nanospheres of type A. A spherical nanochain with the 80-nm-diameter spheres was embedded in the SWG. The interactions between light emerging from SWG and the electric field near the sample surface that affects the properties of the images produced by NSOM are analyzed using a three dimensional finite-difference time-domain method. The effects of the optical field distribution generated by some factors are also discussed. A method of controlling the light field localized in the SWG is proposed that uses the external protrusion (dielectric sphere). The proposed structure will yield some useful information and give an idea of applications in NSOM.
Angiotensin antagonists: overview and projection. (1976)

President Roosevelt describes General Wilson's conduct as "infamous" and he continues to inspire attacks from the New York Sun . The Democratic campaign committee and Democratic newspapers have sent spies to Cuba to find political and personal ammunition to use against Wood. Roosevelt promises to fight for Wood.
Integrated lithium niobate photonic platform (2023)

I will discuss progress on the development of ultra-low loss thin film lithium niobate (TFLN) photonic platform and its application in classical and quantum information processing. Examples of devices to be presented include low power consumption and high bandwidth electro-optic (EO) modulators and EO frequency comb sources, as well as their integration with high power lasers, of interest for applications in optical communications and microwave photonics. TFLN is also promising for spectral and temporal control of non-classical light. In particular, I will discuss the development of quantum transducers and photonics needed for realization of multiplexed quantum repeaters.
PACS: A Dataset for Physical Audiovisual CommonSense Reasoning (2022)

In order for AI to be safely deployed in real-world scenarios such as hospitals, schools, and the workplace, it must be able to robustly reason about the physical world. Fundamental to this reasoning is physical common sense: understanding the physical properties and affordances of available objects, how they can be manipulated, and how they interact with other objects. Physical commonsense reasoning is fundamentally a multi-sensory task, since physical properties are manifested through multiple modalities - two of them being vision and acoustics. Our paper takes a step towards real-world physical commonsense reasoning by contributing PACS: the first audiovisual benchmark annotated for physical commonsense attributes. PACS contains 13,400 question-answer pairs, involving 1,377 unique physical commonsense questions and 1,526 videos. Our dataset provides new opportunities to advance the research field of physical reasoning by bringing audio as a core component of this multimodal problem. Using PACS, we evaluate multiple state-of-the-art models on our new challenging task. While some models show promising results (70% accuracy), they all fall short of human performance (95% accuracy). We conclude the paper by demonstrating the importance of multimodal reasoning and providing possible avenues for future research.
Self-healing in wideband packet networks (1990)

A brief overview is given of wideband packet technology (WPT), with special attention to the features affecting the feasibility of self-healing, a method for automatic failure recovery proposed herein. The objectives of self-healing are set forth, and the failure detection strategy is described. With this strategy, nondisruptive trunk monitoring (self-monitoring) at the data link layer of an open system interconnection (OSI) reference model is performed to detect facility failure of under 1 s. The bit error rate (BER) on a transmission link is estimated on the basis of counts of the number of packets with cyclic redundancy check (CRC) errors at the data link layer. This failure detection strategy can respond to link failures for any given traffic mix by the provisioning of duration and level of unacceptable sustained BER. The mechanisms used to achieve recovery in frame-relay networks using packet streams to carry users' traffic are discussed. Provisioning of the WPT nodes and the network is addressed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Your reactions suggest you liked the movie (2013)

This paper describes a system for automatically rating content - mainly movies and videos - at multiple granularities. Our key observation is that the rich set of sensors available on today's smartphones and tablets could be used to capture a wide spectrum of user reactions while users are watching movies on these devices. Examples range from acoustic signatures of laughter to detect which scenes were funny, to the stillness of the tablet indicating intense drama. Moreover, unlike in most conventional systems, these ratings need not result in just one numeric score, but could be expanded to capture the user's experience. We combine these ideas into an Android based prototype called Pulse, and test it with 11 users each of whom watched 4 to 6 movies on Samsung tablets. Encouraging results show consistent correlation between the user's actual ratings and those generated by the system. With more rigorous testing and optimization, Pulse could be a candidate for real-world adoption.
Deep learning convolutional networks for image quality assessment in ultra-widefield fluorescein angiography (2020)

<strong>Purpose -</strong> Ultra-widefield fluorescein angiography (UWFA) images are used to assess retinal, vascular, and choroidal abnormalities in retinal disease. During image acquisition, images are taken in sequential time points, which allows for interrogation of vascular features, as well as other pathologies, such as leakage. Variations in eye positioning, injection, and camera positioning all contribute to variability in image quality. The purpose of this study was to evaluate the feasibility of automated image quality classification and selection using deep learning. <strong>Methods -</strong> The images for this analysis were composed of 3543 UWFA images obtained during standard UWFA image acquisition. Ground truth image quality was assessed by expert image review, and classified into one of four categories (ungradable, poor, good, or best. 3543 images were used to train the model. A testing set composed of 392 images was used to assess model performance. <strong>Results -</strong> By expert review of 3935 images, 110 (2.8%) were graded as best, 1042 (26.5%) as good, 1156 (29.4%) as poor and 1627 (41.3%) were ungradable. In the testing set, the automated qualit y assessment system showed an overall accuracy of 88% for recognizing between gradable and ungradable images, and 77% accuracy for four-category classification. The receiver operating characteristic (ROC) curve measuring performance of two-class classification (ungradable and gradable) had an AUC of 0.945. <strong>Conclusions –</strong> We created a deep learning classification model that automatic classified UWFA images by quality category. The high degree of accuracy provides evidence that this method could be used to enhance the acquisition of angiogram images and speed up clinic workflow. This could result in reduced manual image grading workload, allow quality-based image presentation to clinicians, and provide near-instantaneous feedback on image quality during image acquisition for photographers.
38.1: Embedded Liquid Crystal Capacitive Touch Screen Technology for Large Size LCD Applications (2009)

Abstract A new embedded touch screen panel (TSP) incorporated with liquid crystal capacitive (LCC) sensors and a‐Si:H TFT amplifiers has been developed. The size of sensor pixels and capacitance values have been optimized for improved sensitivity. The readout current from a sensor pixel is converted to readout voltage data, and a digital calibration process is conducted. A sensing voltage larger than 1V is obtained with 50gf finger touch, and a highly sensitive multi‐finger touch operation has been demonstrated with aproto‐type 16 inch qHD panel.
Biocompatibility and mechanical properties of a totally absorbable composite material for orthopaedic fixation devices (1992)

Bioabsorbable polymer/inorganic phosphate fiber composites are prone to rapid degradation due to water sensitivity of the interface between the degradable polymer and the degradable fiber. This article describes successful fabrication and laboratory evaluation of a candidate bioabsorbable composite implant material with mechanical properties similar to bone. The composite studied was poly(ortho ester) reinforced with randomly-oriented, crystalline microfibers of calcium-sodium-metaphosphate. The component materials showed no acute cytotoxicity as determined by tissue culture agar overlay. Treating the microfibers with a diamine-silane coupling agent improved mechanical properties and slowed degradation in saline, but strength still decreased 50% in 1 week. When the composite material was then coated with a layer of matrix polymer alone it retained 70% of its strength and 70% of its stiffness after 4 weeks exposure to 7.4 pH Tris-buffered saline at body temperature. The marked improvement with the coating can be attributed to the hydrophobicity of poly(ortho esters).
Correlation between defect properties and internal quantum efficiency in blue-emitting InGaN based light emitting diodes (2012)

This study examines the influence of the defect properties on internal quantum efficiency (IQE) in blue InGaN-based light emitting diodes (LEDs). The defect parameter is introduced for estimating defect properties among defect density, size, and defect type that are strongly correlated with IQE in InGaN LED. The value of IQE can be expressed by the value of the defect parameter, which was obtained from transmission electron microscopy and cathodoluminescence measurement.
Dynamics over Signed Networks (2019)

A signed network is a network in which each link is associated with a positive or negative sign. Models for nodes interacting over such signed networks arise from various biological, social, political, and economic systems. As modifications to the conventional DeGroot dynamics for positive links, two basic types of negative interactions along negative links, namely, the opposing rule and the repelling rule, have been proposed and studied in the literature. This paper reviews a few fundamental convergence results for such dynamics over deterministic or random signed networks under a unified algebraic-graphical method. We show that a systematic tool for studying node state evolution over signed networks can be obtained utilizing generalized Perron--Frobenius theory, graph theory, and elementary algebraic recursions.
Management of Refractory Elevated Intracranial Pressure (ICP) in an Immunocompetant Host with Cryptococcal Meningitis (P03.249) (2013)

OBJECTIVE: A case of cryptococcal meningitis in an immunocompetent host with refractory elevated ICP.
Record high-performance RF devices in an advanced FDSOI process enabling integrated Watt-level power amplifiers for WiFi and 5G applications (2019)

High-voltage RF active and passive devices, including LDMOS, fringe capacitors, transformers and inductors with good RF performance, are required for building integrated RF power amplifiers at Watt-level in high-performance cost-effective RF front-end ICs. This paper reports, for the first time, a novel 3.3V / 5V RF-LDMOS with a cutoff frequency beyond 100GHz, designed and fabricated without any additional dedicated mask in an advanced sub-28nm node FDSOI process. For passive devices, by combining the novel RF design with an RF-compatible metal stack, accurate EM simulation, and 4-port RF characterization, a record high Q-factor for a 7V-fringe capacitor, a 2-way transformer and 8-shaped inductors are obtained. The RF performance of these high-voltage (HV) capable devices is comparable to best-in-class devices in RF-HV-centric non-CMOS processes, e.g. SiGe and GaAs. This enables highly integrated cost-effective power amplifiers for both WiFi (5GHz) and 5G (28GHz) applications.
A Prospective Comparative Study in Skin Antiseptic Solutions for Posterior Spine Surgeries (2018)

While CHG-ethanol and PD-I were equally effective at eliminating the bacterial flora from the surgical site, CHG-ethanol showed a more favorable long-lasting effect for skin antisepsis in posterior spine surgeries.
A Study on a Surface Ablation of the Jet Vane System in a Rocket Nozzle (2004)

During the rocket propulsion process, the jet vane which is installed in the rear side of rocket nozzle part is ablated chemically or mechanically due to the interaction of vane with a combusted gas. In this study, the simulation for the chemical ablation phenomenon of jet vane is tried out as a basic research on the jet vane performance test. Also, distributions of thermal boundary conditions such as heat transfer coefficient and recovery temperature are calculated and used as the input values for the acquisition of surface ablation rate. The thermal boundary layer integral method is applied to the calculation of these boundary conditions. User defined functions are inserted into a numerical code (FLUENT) for calculation of thermal boundary conditions and surface ablation rate. Leading edge on a jet vane is heated heavily compared with the side surfaces and therefore the ablation occurs primarily on that part. When the jet vane is rotated, the windward surface is heated and ablated more than the leeward surface. However, the ablation rate on a side surface is much lower than that on a leading edge of vane, so ablation of jet vane side surface can be ignored during the jet vane ablation simulation. In about 10 seconds of vane operation time, total ablation area is calculated not to be over 4% of the vane side surface area.
A General and Special Catalyst for Suzuki–Miyaura Coupling Processes (2010)

Biaryl-Monophosphorliganden mit einem 2,3-Dihydrobenzo[d][1,3]oxaphosphol-Gerüst ergeben hoch effiziente palladiumkatalysierte Suzuki-Miyaura-Kreuzkupplungen mit verschiedenartigen Substraten. Der Ligand 1 eignet sich außerordentlich gut für Kupplungen von sterisch stark gehinderten Arylboronsäuren.
Synthesis and polymerization of propargylamine and aminoacetonitrile intercalation compounds (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and polymerization of propargylamine and aminoacetonitrile intercalation compoundsJohn E. Pillion and Mark E. ThompsonCite this: Chem. Mater. 1991, 3, 5, 777–779Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/cm00017a006https://doi.org/10.1021/cm00017a006research-articleACS PublicationsRequest reuse permissionsArticle Views417Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts