gebhart/patrepeval huggingface dataset:
[Infection with human parvovirus B19 ('fifth disease') during pregnancy: potential life-threatening implications for the foetus]. (2008)

Four pregnant women, aged 29, 32, 36 and 36 years, respectively, were diagnosed with Human parvovirus B19 (B19V) infection. Only the first woman had exanthema and fever. In the first three cases, the source of infection appeared to be another child; two of these children were infected during a school outbreak. All four foetuses were infected, but the first foetus was asymptomatic and healthy at birth. The second foetus had anaemia and increased blood flow in the middle cerebral artery; it received an intrauterine transfusion and was healthy at birth. The third foetus was almost immobile and had cardiomegaly and hydrops fetalis; it was dead upon induced birth. In the fourth case, pregnancy was uneventful until two days before parturition, when the mother reported a decrease in foetal movement. The infant was born and developed respiratory insufficiency after 8 hours. Imaging revealed multiple bilateral lesions in frontal, occipital and parietal white matter consistent with infarction. The infant died after 5 days. Infection with B19V is associated with a wide range of clinical presentations and outcomes. Effects may range from an uncomplicated pregnancy to severe hydrops fetalis or intrauterine foetal death. Maternal symptoms may be aspecific, which complicates early diagnosis. When maternal B19V infection is suspected, immediate investigation for recent B19V infection should be performed. Quantitative B19 viral load measurements may provide insight into the stage of infection and may guide foetal monitoring. Referral to a foetal therapy unit is essential for hydrops fetalis or severe foetal anaemia. Intrauterine transfusion with erythrocytes significantly improves foetal outcome. Despite a successful transfusion procedure, long-term neurodevelopment may be affected, and developmental follow up is advised.
Capture and Visualization of Hydrogen Sulfide by a Fluorescent Probe (2011)

Reaktionsbasierter Nachweis: Eine Fluoreszenzsonde für den Nachweis von Schwefelwasserstoff wurde auf Basis der H2S-vermittelten Bildung von Benzodithiolon entwickelt und evaluiert. Die Sonde zeigte eine gute Selektivität und Empfindlichkeit für Schwefelwasserstoff.
The auxin transporter PIN1 and the cytokinin transporter AZG1 interact to regulate the root stress response (2020)

Abstract Root system development is crucial for optimal growth and yield in plants, especially in sub-optimal soil conditions. The architecture of a root system is environmentally responsive, enabling the plant to exploit regions of high nutrient density whilst simultaneously minimizing abiotic stress. Despite the vital contribution of root systems to the growth of both model and crop species, we know little of the mechanisms which regulate their architecture. One factor which is relatively well understood is the transport of auxin, a plant growth regulator which defines the frequency of lateral root (LR) initiation and the rate of LR outgrowth. Here we describe a search for proteins which regulate RSA by interacting directly with a key auxin transporter, PIN1. The native separation of PIN1 identified several co-purifying proteins. Among them, AZG1 was subsequently confirmed as a PIN1 interactor. AZG1-GFP fusions co-localized with PIN1 in procambium cells of the root meristem. Roots of azg1 plants contained less PIN1 and blocking proteolysis restored PIN1 levels, observations which are consistent with PIN1 being stabilized by AZG1 in the plasma membrane. Furthermore, we show that AZG1 is a cytokinin import protein; accordingly, azg1 plants are insensitive to exogenously applied cytokinin. In wild-type plants, the frequency of LRs falls with increasing salt concentration, a response which is not observed in azg1 x azg2 plants, although their drought response is unimpaired. This report therefore identifies a potential point for auxin:cytokinin crosstalk in the environmentally-responsive determination of root system architecture.
High energy density polymer composites for pulse-power applications (2010)

In this work, we have investigated the dielectric integrity of P(VDF-HFP)/CCTO and PS/CCTO composites. An attempt has been made to understand the effect of filler preparation method (sol-gel vs. solid state) and loading on dielectric permittivity, loss, DC breakdown, and energy density of the resulting composites. The composites show high dielectric permittivity with increasing addition of CCTO fillers, presumably due to the giant dielectric permittivity exhibited by these fillers. DC breakdown measurements performed by embedding spherical electrodes into composite films show low breakdown strength at very high filler loadings (40 vol. %) possibly due to percolative effects of fillers. Nonetheless, at lower filler loadings (&#60;20 vol. %), the composites show high permittivities and lower reduction in breakdown strength leading to high calculated energy densities of 12 J/cc. With an optimized filler loading, we have achieved a composite system capable of storing large electric energy desirable for pulse power application.
Supplementary Figure legends from Predicting the Grade of Dysplasia of Pancreatic Cystic Neoplasms Using Cyst Fluid DNA Methylation Markers (2023)

&lt;p&gt;Supplementary Figure legends&lt;/p&gt;
Pollination studies in Tagetes minuta, an important medicinal and aromatic plant (2017)

An improved understanding of the mechanics of pollination and its active management is crucial in any species in order to maximize gain from any improvement programmes. Present studies on pollination behaviour of Tagetes minuta revealed higher seed germination besides seedling vigour in open pollinated seeds coupled with non-significant seed yield between open and autogamously produced seeds. These studies lead to hypothesize that this species is i) mostly self-pollinated ii) genetic pure lines will be easier to maintain in the species as seeds harvested would be of autogamous nature without needing artificial enclosures and iii) open crossed seeds show higher germination percentage
Energy efficient data flow transformation for Givens Rotation based QR Decomposition (2014)

QR Decomposition (QRD) is a typical matrix decomposition algorithm that shares many common features with other algorithms such as LU and Cholesky decomposition. The principle can be realized in a large number of valid processing sequences that differ significantly in the number of memory accesses and computations, and hence, the overall implementation energy. With modern low power embedded processors evolving towards register files with wide memory interfaces and vector functional units (FUs), the data flow in matrix decomposition algorithms needs to be carefully devised to achieve energy efficient implementation. In this paper, we present an efficient data flow transformation strategy for the Givens Rotation based QRD that optimizes data memory accesses. We also explore different possible implementations for QRD of multiple matrices using the SIMD feature of the processor. With the proposed data flow transformation, a reduction of up to 36% is achieved in the overall energy over conventional QRD sequences.
Vietnamese infant and childhood mortality in relation to the Vietnam War. (1993)

The data are limited by assignment of birth location on the basis of mother's current residence and by inadequate information on areas of war activity. Nonetheless, the data do not indicate a widespread, sizable adverse effect of the war on national infant and childhood mortality in Vietnam but suggest detrimental effects in selected provinces.
The Reaction of Elemental Sulfur with Organic Compounds. IV. The Reactions of N-Arenesulfonylsulfilimine and Sulfoximine with Sulfur and Diaryl Disulfide (1972)

Abstract The reactions of elemental sulfur and diaryl disulfide with the compounds bearing a semipolar S→N linkage were investigated. Elemental sulfur was found to react with N-arenesulfonylsulfilimine and sulfoximine affording the corresponding sulfide and the sulfoxide respectively. Diaryl disulfide also was found to undergo similar reactions with these compounds. In the reaction of diaryl disulfide with N-arenesulfonylsulfilimine, N,N-bis-(arylthio)arenesulfonamide was obtained as a main product besides the corresponding sulfide. The mechanisms of these reactions are discussed.
TH‐A‐213A‐01: Multi‐Modality Image‐Guided Near Infrared Spectroscopy: Optimization and Clinical Applications (2009)

Image‐guided near infrared spectroscopy (IG‐NIRS) provides deep tissue functional characterization at high resolution. This approach combines conventional imaging techniques such as MRI and CT with optical near infrared technologies, giving information directly relating to the vascular and metabolic status of tissue in‐vivo. The resultant estimates of total hemoglobin, oxygen saturation, water, lipids and scatter provide a window towards understanding the mechanisms of cancer in terms of angiogenesis, hypoxia, changes in the interstitium and cell organelle structural changes. This type of spectroscopy has been applied for breast cancer diagnosis and treatment monitoring, as well as image‐guided fluorescence in small‐animals. Optimization of these systems is essential to provide quantitative and accurate spectroscopy. This optimization encompasses system design for simultaneous multi‐modality image acquisition, methods for intelligently combining spatial anatomical structure from MRI/CT into optical recovery, image segmentation, visualization and interpretation of novel combined optical and MRI/CT parameters. This talk will provide an over‐view of these aspects of multi‐modality imaging as well as results from in‐vivo clinical applications. Learning Objectives: 1. Understanding the rationale for multi‐modality IG‐NIRS systems 2. Understanding the type of information and contrast available through these systems 3. Understanding the challenges towards clinical use of these systems.
Supplementary Table S9 from Detection of Promoter DNA Methylation in Urine and Plasma Aids the Detection of Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Gene Methylation Detection, Sensitivity, Specificity Using Detectable vs. Non-detectable cutoff in blacks&lt;/p&gt;
CMOS Radio Design for Complete Single Chip GPS SoC (2005)

A GPS radio design for a complete single chip GPS receiver using 0.18-μm CMOS is presented. The complete single chip GPS receiver satisfies several key requirements for mobile applications, such as compactness, low power, and high sensitivity. The radio part, including the RF front end, the RF/IF PLLs, and IF functions, occupies 2.0 x 2.3 mm in a total chip area of 6.3 x 6.3 mm. It is fabricated using 0.18-μm CMOS technology utilizing MIM capacitors. The radio part operates within a 1.6 to 2.0 V supply voltage range and consumes 27 mW at 1.8 V. The whole GPS SoC consumes 57 mW for a fully functional chip and provides a high sensitivity of -152 dBm. The radio design features countenneasures against substrate coupling noise from the digital part.
An Architecture for Electronic Throttle Control Systems (2003)

&lt;div class="htmlview paragraph"&gt;This paper presents an architecture for monitoring and controlling an electronic throttle control system. The architecture contains two processors, the MAIN and the MCP. The MAIN is responsible for calculating the desired throttle position and the MCP for positioning the throttle using feedback control. The two processors measure all pedal and throttle sensors redundantly and continuously monitor the state-of-health of the other processor. Depending on the fault(s) detected, actuator default position, limited throttle authority, forced idle, Bowden cable mode or engine shutdown remedial action may be taken.&lt;/div&gt;
Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae (2017)

Natural product screening programs have uncovered molecules from diverse natural sources with various biological activities and unique structures. However, much is yet underexplored and additional information is hidden in these exceptional collections. We applied untargeted mass spectrometry approaches to capture the chemical space and dispersal patterns of metabolites from an in-house library of marine cyanobacterial and algal collections. Remarkably, 86% of the metabolomics signals detected were not found in other available datasets of similar nature, supporting the hypothesis that marine cyanobacteria and algae possess distinctive metabolomes. The data were plotted onto a world map representing eight major sampling sites, and revealed potential geographic locations with high chemical diversity. We demonstrate the use of these inventories as a tool to explore the diversity and distribution of natural products. Finally, we utilized this tool to guide the isolation of a new cyclic lipopeptide, yuvalamide A, from a marine cyanobacterium.
Mouse Genetic Evidence That Tranilast Reduces Smooth Muscle Cell Hyperplasia via a p21 WAF1 -Dependent Pathway (2002)

Our findings provide genetic evidence that tranilast inhibits intimal hyperplasia via a p21-dependent pathway, an activity that may contribute to its efficacy in the prophylactic treatment of postangioplasty restenosis.
Nonlinear Mechanics of Interlocking Cantilevers (2017)

The use of large-deflection springs, tabs, and other compliant systems to provide integral attachment, joining, and retention is well established and may be found throughout nature and the designed world. Such systems present a challenge for mechanical analysis due to the interaction of contact mechanics with large-deflection analysis. Interlocking structures experience a variable reaction force that depends on the cantilever angle at the contact point. This paper develops the mathematical analysis of interlocking cantilevers and provides verification with finite element analysis and physical measurements. Motivated by new opportunities for nanoscale compliant systems based on ultrathin films and two-dimensional (2D) materials, we created a nondimensional analysis of retention tab systems. This analysis uses iterative and elliptic integral solutions to the moment–curvature elastica of a suspended cantilever and can be scaled to large-deflection cantilevers of any size for which continuum mechanics applies. We find that when a compliant structure is bent backward during loading, overlap increases with load, until a force maximum is reached. In a force-limited scenario, surpassing this maximum would result in snap-through motion. By using angled cantilever restraint systems, the magnitude of insertion force relative to retention force can vary by 50× or more. The mathematical theory developed in this paper provides a basis for fast analysis and design of compliant retention systems, and expands the application of elliptic integrals for nonlinear problems.
Guest/Host Relationships in the Synthesis of the Novel Cage-Based Zeolites SSZ-35, SSZ-36, and SSZ-39 (1999)

Here, we report the synthesis and structure of three high-silica molecular sieves, SSZ-35, SSZ-36, and SSZ-39, that are prepared from a library of 37 different cyclic and polycyclic quaternized amine molecules that are used as structure-directing agents (SDAs). The size and shape of the quaternized amine molecules are purposely designed in order to obtain novel zeolite structures, and the synthesis of these molecules is presented. The selectivity for the three molecular sieve phases is found to depend on both the SDA and the degree of heteroatom lattice substitution of Al3+ or B3+ in the silicate framework. Molecular modeling is utilized to probe the effects of the nonbonded SDA/zeolite-framework interaction energy on the selectivity for the observed molecular sieve phase. The Rietveld refinement of the powder X-ray data confirms the structure of the SSZ-39 zeolite to be isomorphous with the aluminophosphate molecular sieve, SAPO-18 (AEI). The structure of SSZ-36 is found to possess a range of fault probabilities between the two-dimensional channel system, end-member polymorphs, ITQ-3 and RUB-13 (International Zeolite Association Codes ITE and RTH, respectively). The SSZ-35 structure is reported to contain a one-dimensional pore system possessing stacked cages circumscribed by alternating rings of 10 and 18 tetrahedral atoms (10- and 18-membered rings).
Structure–activity relationship study of PROTACs against hematopoietic prostaglandin D2 synthase (2022)

Degradation of hematopoietic prostaglandin D<sub>2</sub> synthase (H-PGDS) by proteolysis-targeting chimeras (PROTACs) is expected to be important in the treatment of allergic diseases and Duchenne's muscular dystrophy. We recently reported that <b>PROTAC(H-PGDS)-</b>7 (<b>PROTAC</b>1), which is composed of H-PGDS inhibitor (TFC-007) and cereblon (CRBN) E3 ligase ligand (pomalidomide), showed potent H-PGDS degradation activity. Here, we investigated the structure-activity relationships of <b>PROTAC</b>1, focusing on the C4- or C5-conjugation of pomalidomide, in addition, the H-PGDS ligand exchanging from TFC-007 with the biaryl ether to TAS-205 with the pyrrole. Three new PROTACs were evaluated for H-PGDS affinity, H-PGDS degrading activity, and inhibition of prostaglandin D<sub>2</sub> production. All compounds showed high H-PGDS degrading activities, but <b>PROTAC(H-PGDS)-</b>4<b>-TAS-205</b> (<b>PROTAC</b>3) was slightly less active than the other compounds. Molecular dynamics simulations suggested that the decrease in activity of <b>PROTAC</b>3 may be due to the lower stability of the CRBN-PROTAC-H-PGDS ternary complex.
Early identification of aortic valve sclerosis using iron oxide enhanced MRI (2009)

Although iron oxide labeling of macrophage infiltration in AVS has the potential to detect the disease process early, a macrophage-specific iron compound rather than passive targeting may be required.
Synergism between Granulosa and Theca-Interstitial Cells in Estrogen Biosynthesis by Gonadotropin-Treated Rat Ovaries: Studies on the Two-Cell, Two-Gonadotropin Hypothesis Using Steroid Antisera1 (1986)

In mammalian ovaries, luteinizing hormone (LH) induces androgen biosynthesis by theca interna cells, whereas both follicle-stimulating hormone (FSH) and LH stimulate aromatase activity by granulosa cells. The joint action of these two types of cell and pituitary hormones forms the basis of a 2-cell, 2-gonadotropin hypothesis for biosynthesis of estrogen. We tested the synergism between these cell types using antisera against the estrogen precursors progesterone and testosterone. Ovaries were obtained from immature rats two days after a single injection of pregnant mare serum gonadotropin (PMSG). Granulosa cells were obtained by puncturing the follicles, and ovarian remnants were dissociated with collagenase to derive cells from the theca interstitium. Granulosa and theca interstitial cells were cultured alone or in combination for 20 h. Granulosa cells secreted negligible amounts of estrogen and testosterone, but contained high aromatase activity. Treatment with both FSH and human chorionic gonadotropin (hCG) increased production of progesterone in granulosa cells. In contrast, theca interstitial cells had negligible aromatase activity. Treatment with hCG, but not FSH, increased androgen production by theca interstitium; the hCG action was further augmented by the inclusion of exogenous progesterone. Furthermore, co-culture of gonadotropin-treated granulosa and theca interstitial cells resulted in substantial increases in estrogen production, indicating synergism between the two types of cell. The increases in estrogen production in the co-cultures were accompanied by decreases in progesterone content. To test the possibility that progesterone released by granulosa cells may serve as a substrate for production of androgen in theca cells, specific antiserum was used to adsorb progesterone present in the medium. Addition of the progesterone antibody inhibited gonadotropin-stimulated production of testosterone (39% decrease) and estrogen (64% decrease) by the combined cell cultures. The inhibitory effect on estrogen production could be reversed by the addition of progesterone (10(-6) M) or testosterone (10(-6) M) but not by the addition of a synthetic progestin, R5020. Since testosterone released from theca cells may serve as the substrate for aromatases in granulosa cells, specific testosterone antiserum was also used. Production of estrogens by the combined cell cultures was inhibited (78%) by the testosterone antiserum, but the inhibitory effect was completely reversed by exogenous testosterone or progesterone. Thus, synergistic interactions between granulosa and theca interstitial cells are important in effecting maximal estrogen biosynthesis.(ABSTRACT TRUNCATED AT 400 WORDS)
Cooperative highway traffic: multi-agent modelling and robustness to local perturbations. (2013)

As cooperative systems, a.k.a. connected vehicles, enable the communication and exchange of information between vehicles and infrastructure, it is expected that their communication capabilities can lead to a better active traffic management on urban motorways. In such a context, technological constraints must be the basis for any management strategy. If it has been analytically proven that communication can help stabilize traffic flow at a microscopic level, it is interesting to evaluate realistic communication strategies taking into consideration multiple perturbations such as sensors faults or driver cooperation. In this paper, a three-layer multi-agent framework is used to model and control the homogenization of traffic flow. The physical layer coordinates the vehicles dynamics based on a cooperative car following model. This layer includes cooperation derived from the communication and trust layers that respectively manage information and its reliability. Simulation results highlight the positive impacts of communication and control on traffic flow stability.
ChemInform Abstract: Tandem Pd/Au‐Catalyzed Route to α‐Sulfenylated Carbonyl Compounds from Terminal Propargylic Alcohols and Thiols. (2014)

Abstract The reaction is proposed to proceed through a Pd‐catalyzed regioselective hydrothiolation at the terminal triple bond followed by an Au‐catalyzed 1,2‐hydride migration.
Metallocarbohedrenes: recent advancements (1998)

The recently discovered family of molecular clusters, metallocarbohedrenes (metcars), have generated considerable excitement in cluster chemistry. Metcar research has spread into a large number of transition metals and mixed metals and recent investigations point to the complexity and variety of metcar chemistry. The structure and electronic properties are vigorously studied by various methods of theory. Many of the earlier assumptions have been proved wrong by carefully planned experiments and detailed computational studies. Metcar research will certainly intensify in the years to come in view of their predieted novel properties.
The submaximal effort tourniquet test: Its use in evaluating experimental and chronic pain (1979)

The submaximal effort tourniquet test has been widely used to evaluate experimental and chronic pain; however, there has been great variation in the manner in which the test has been applied. The present study systemitically evaluates how different levels of exercise duration and effort affect subjects' report of pain. The data indicate the following: (1) the manner in which the exercise is performed has an important effect on subjects' rating of pain, and (2) under all conditions studied, the pain ratings do not increase as a linear function of time. Both findings warrant precautions when using the submaximal effort tourniquet test to study experimental and chronic pain.