gebhart/patrepeval huggingface dataset:
Air Force Center of Excellence on Bio-nano-enabled Inorganic/Organic Nanostructures and Improved Cognition (BIONIC) (2015)

Abstract : Future demands on the Air Force Warfighter will require dramatic advances in active materials utilized by the Warfighter (e.g., for remote, prolonged energy conversion and highly tunable sensing/response), as well as in the training and performance of the Warfighter (e.g., for enhanced memory and attention). Of equal importance for future Air Force technology is the training of U.S. graduate students in the development of such advanced materials and protocols for enhanced cognition. The BIONIC Air Force Center of Excellence has been focused on utilizing the expertise and capabilities of integrated teams of Georgia Tech faculty (from the Colleges of Engineering and Science), Emory University faculty, and Air Force researchers (from the Materials & Manufacturing Directorate and the Human Effectiveness Directorate of the Air Force Research Laboratory, AFRL) to: i) Fabricate and evaluate inorganic/organic nanocomposites for efficient, remote energy conversion, ii) Fabricate and evaluate inorganic/organic nanocomposites for tunable, adaptive surface structures, and iii) Develop tools and assessment methodologies for the optimization of critical cognitive processes.
Dolomite Stimulation with Retarded Acids (2021)

Abstract Globally, dolomite formations are important reservoirs for oil and gas. Acid stimulation is commonly used to extend the life of carbonate reservoirs, and a good understanding of the fluid performance is essential for effective treatment design. Three acids, hydrochloric acid (HCl), emulsified HCl, and a single-phase retarded acid based on HCl, were assessed for their ability to create wormholes in Silurian dolomite under laboratory conditions using a standard core flow experiment. Select cores were imaged by X-ray computed tomography to visualize the wormhole morphology. Similar experiments in Indiana limestone was used as a control. The core flow experiments showed that the pore volume to break-through (PVbt) values for the retarded acids in Indiana limestone were less sensitive to changes in temperature overall than unmodified HCl. For Silurian dolomite though, the opposite is observed. HCl has uniformly high PVbt values at lower (200 °F) and higher (325 °F). The emulsified acid and the single-phase retarded acid are more efficient than HCl, but the difference is smaller at 325 °F. Core images revealed that all three fluids had some degree of wormhole branching at 200 °F and much less branching at 325 °F. By visual inspection, the single-phase retarded acid has less ramification than HCl and the emulsified acid. Overall, the results show that retarded acids should make effective stimulation fluids for dolomite reservoirs.
Autohydrolysis and aqueous ammonia extraction of wheat straw: effect of treatment severity on yield and structure of hemicellulose and lignin (2014)

Pseudo-lignin accumulation in wheat straw autohydrolysis was revealed by relative double detection high-performance size-exclusion chromatography and confirmed by CuO oxidation.
Early Detection of Lymphocyte Stimulation and Mixed Lymphocyte Interaction in Man with a Semimicro Protein Synthesis Assay (1974)

Abstract A rapid semimicro assay for lymphocyte activation in man is described. It is based upon the stimulation of protein synthesis (SPS) in peripheral blood lymphocytes cultured in serum-free medium with soluble antigens, phytomitogens or allogeneic lymphocytes. Cellular response to PHA is discernible in 4 hr and response to antigen in 16 to 24 hr. Stimulation in mixed lymphocyte cultures can be detected as early as 8 to 10 hr and invariably by 42 hr. The assay permits detection of lymphocyte activation earlier and with greater precision than the widely employed thymidine incorporation blast transformation system.
The Simulation of the Abdominal MECG (1981)

In order to obtain an insight into the surface potential distribution of the maternal electrocardiogram (MECG) on the abdomen during pregnancy, a simulation model is set up. As a function of the shape of the abdomen and the internal conduction difference between uterus and surroundings, the surface potentials are calculated on a ring at the umbilicus level for the x, y, and z components of the maternal heart vector.
Silver(I)/peroxydisulfate-induced oxidative decarboxylation of amino acids. A chemical model for a possible intermediate in the monoamine oxidase-catalyzed oxidation of amines (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSilver(I)/peroxydisulfate-induced oxidative decarboxylation of amino acids. A chemical model for a possible intermediate in the monoamine oxidase-catalyzed oxidation of aminesYury Zelechonok and Richard B. SilvermanCite this: J. Org. Chem. 1992, 57, 21, 5787–5790Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/jo00047a045https://doi.org/10.1021/jo00047a045research-articleACS PublicationsRequest reuse permissionsArticle Views513Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
New skid avoidance method for electric vehicle with independently controlled 4 in-wheel motors (2003)

Novel skid detection method for electric vehicle (EV) with independently controlled four in-wheel motors is proposed. This proposed method can detect the skidding of wheels with only the values of current and rotating velocity of each motor. Estimation of vehicle chassis velocity or wheel absolute velocity is not required any more, and this is remarkable advantage over conventional methods. In this proposed method, skid is detected with the dependence of traction force on motor torque. Traction force is estimated with simple disturbance observer, thus, the exact value of shaft input torque is required. It is quite easy for EVs, but not so for internal combustion vehicles (ICVs). The proposed algorithm is examined with experimental results with a laboratory-made electric vehicle "UOT Electric March". These experimental data show the effectiveness of the authors' new skid detection method. They also carried out a simulation to show how to prevent skidding with the proposed skid detection method.
Modulation of guanylate cyclase by lipoxygenase inhibitors. (1986)

Drugs that inhibit endothelium-dependent relaxation were tested to determine their effect on soluble guanylate cyclase purified from dog aorta. Basal, arachidonic acid (10(-5) M)-stimulated, and nitroprusside (5 X 10(-5) M)-stimulated guanylate cyclase activities were inhibited by methylene blue and the lipoxygenase inhibitors nordihydroguaiaretic acid and eicosatetraynoic acid. The effective inhibitory doses were in the range of those that have been reported to inhibit endothelium-dependent relaxation. Other compounds known to inhibit endothelium-dependent relaxation had little or no effect on guanylate cyclase activity. Basal guanylate cyclase activity was more resistant to inhibition than were activated states of the enzyme. The data suggest that reported inhibition of endothelium-dependent relaxation by some lipoxygenase inhibitors may be the result, at least in part, of their direct effect on guanylate cyclase activity.
Supplementary Figure Legends 1-10, Video Legends 1-3, Methods from Unexpected Dissemination Patterns in Lymphoma Progression Revealed by Serial Imaging within a Murine Lymph Node (2023)

&lt;p&gt;PDF file - 55K&lt;/p&gt;
Dasatinib (D) in patients (pts) with chronic myelogenous leukemia (CML) in myeloid blast crisis (MBC) who are imatinib-resistant (IM-R) or IM-intolerant (IM-I): Results of the CA180006 ‘START-B’ study (2006)

6529 Background: Dasatinib (D) (BMS-354825) is an oral, multitargeted tyrosine kinase inhibitor of Bcr-Abl and SRC with activity against IM-R cell lines. In a phase I study, there was preliminary evidence that D was active in MBC-CML patients (pts). Methods: START B is an open-label study of D in IM-R or IM-I MBC carried out in 46 sites worldwide. From December 2004 to May 2005, 124 MBC pts were accrued. D was given orally at 70 mg twice a day (BID) with dose escalation to 100 mg BID for poor initial response or dose reductions to 50 mg and 40 mg BID for toxicity. Pts had weekly blood counts and monthly bone marrow evaluations, including cytogenetics. The primary endpoint was confirmed (minimum 4 weeks duration) major hematologic response (MaHR). Results: Data are currently available on the first 74 pts (68 IM-R, 6 IM-I). Median age was 55 years, 55% were male. Other prior therapy included interferon in 55% of pts and bone marrow transplant (BMT) in 12%. Prior IM dose was &gt;600 mg/day in 49% of pts and 47% of pts received IM for &gt; 3 years. At baseline, the WBC count was ≥20 × 10 3 /mm 3 in 46%, the platelet count was &lt; 100 × 10 3 /mm 3 in 72% of pts and 35% of pts had ≥ 50% bone marrow blasts. Mutations in the BCR-ABL domain were found in 27/63 (43%) pts. Median duration of therapy was 3.5 months. D doses were reduced in 35% pts, temporarily interrupted in 58% pts, and escalated in 41% pts. With a minimum of 6-month follow-up, hematologic response was seen in 39 (53%) pts: confirmed MaHR in 24 (32%) pts, Complete in 18 (24%) and No Evidence of Leukemia in 6 (8%). Major cytogenetic responses were documented in 22 (30%) pts and was complete in 20 (27%). The median time to MaHR was 56 days. There was no loss of response in pts with MaHR; the duration of MaHR ranged from 1.2+ to 7.8+ months. The median PFS had not been reached. Severe myelosuppression was very common. Non-hematologic toxicities were usually mild to moderate. Most common Grade 3–4 toxicities included diarrhea in (7%), pleural effusion (9%), nausea (4%). Peripheral edema was reported in 14% of pts (0% Grade 3–4), and rash in 11% of the pts (0% Grade 3–4). Conclusions: Dasatinib was highly effective in IM-R pts with MBC with durable MaHR. Data on all 124 pts will be presented at the meeting. [Table: see text]
CALGB 90203 (Alliance): Radical prostatectomy (RP) with or without neoadjuvant chemohormonal therapy (CHT) in men with clinically localized, high-risk prostate cancer (CLHRPC). (2019)

5079 Background: Neoadjuvant CHT followed by RP did not increase 3-year biochemical progression free-survival (bPFS) compared to RP alone in men with CLHRPC. However, there is evidence that bPFS and overall survival over time was improved. In the current analysis we assessed whether CHT followed by RP improved pathological specimen features compared to RP alone. Methods: CALGB 90203 (Alliance) is a Phase III study which randomly assigned, in a 1:1 fashion, men with CLHRPC [biopsy Gleason Grade Group (GGG) 4 or 5 or Kattan pre-op nomogram bPFS &lt; 60%] to RP alone or RP plus neoadjuvant CHT [androgen deprivation plus docetaxel (75 mg/m 2 every 3 weeks for 6 cycles)]. We conducted an exploratory analysis comparing histologic findings, determined at the treating center, in the RP specimens of men receiving CHT plus RP and men treated with RP alone. We used the Chi-square test, with P-values adjusted by the Holm method for multiple comparisons. Results: A total of 788 men (median age, 62; range: 32-83 years) were randomized, with 738 ultimately undergoing RP. There was no difference in pathologic GGG (Table). Men treated with neoadjuvant CHT had a lower pathologic T-stage and lower likelihood of having seminal vesicle invasion (SVI), positive pelvic lymph nodes, or positive surgical margins (SM) (Table). Conclusions: Most pathologic features in the RP specimen were improved in men receiving neoadjuvant CHT compared to RP alone. The relationship between pathologic changes and the development of metastasis and survival require further analysis. RP pathologic outcomes. Summary statistics are calculated for the number of patients with non-missing data for each characteristic. Clinical trial information: NCT00430183. [Table: see text]
Paracellular bicarbonate flux across human cystic fibrosis airway epithelia tempers changes in airway surface liquid pH (2020)

Airway epithelia control the pH of airway surface liquid (ASL), thereby optimizing respiratory defences. Active H<sup>+</sup> and HCO<sub>3</sub><sup>-</sup> secretion by airway epithelial cells produce an ASL that is acidic compared with the interstitial space. The paracellular pathway could provide a route for passive HCO<sub>3</sub><sup>-</sup> flux that also modifies ASL pH. However, there is limited information about paracellular HCO<sub>3</sub><sup>-</sup> flux, and it remains uncertain whether an acidic pH produced by loss of cystic fibrosis transmembrane conductance regulator anion channels or proinflammatory cytokines might alter the paracellular pathway function. To investigate paracellular HCO<sub>3</sub><sup>-</sup> transport, we studied differentiated primary cultures of human cystic fibrosis (CF) and non-CF airway epithelia. The paracellular pathway was pH-insensitive at pH 6.0 vs. pH 7.4 and was equally permeable to Cl<sup>-</sup> and HCO<sub>3</sub><sup>-</sup> . Under basal conditions at pH ∼6.6, calculated paracellular HCO<sub>3</sub><sup>-</sup> flux was weakly secretory. Treating epithelia with IL-17 plus TNFα alkalinized ASL pH to ∼7.0, increased paracellular HCO<sub>3</sub><sup>-</sup> permeability, and paracellular HCO<sub>3</sub><sup>-</sup> flux was negligible. Applying IL-13 increased ASL pH to ∼7.4 without altering paracellular HCO<sub>3</sub><sup>-</sup> permeability, and calculated paracellular HCO<sub>3</sub><sup>-</sup> flux was absorptive. These results suggest that HCO<sub>3</sub><sup>-</sup> flux through the paracellular pathway counterbalances, in part, changes in the ASL pH produced via cellular mechanisms. As the pH of ASL increases towards that of basolateral liquid, paracellular HCO<sub>3</sub><sup>-</sup> flux becomes absorptive, tempering the alkaline pH generated by transcellular HCO<sub>3</sub><sup>-</sup> secretion.
Distributed spectrum monitoring and surveillance using a cognitive radio based testbed (2016)

This paper described the development and implementation of a distributed spectrum monitoring and surveillance testbed for identifying and locating RF signals using the Universal Software Radio Peripheral (USRP). We use a centralized RF trace collection testbed to establish the baseline, and we focus on distributed RF trace collection. Challenges associated with synchronization is identified and candidate solutions are discussed. The distributed testbed was implemented using NI USRPs (293×/295×) with LabVIEW. The complex nature of implementing the distributed case necessitate the choice of LabVIEW because of the versatile features provided. Potential applications are discussed and sample traces are demonstrated.
Model and Experimental Study of Hydrodynamic Coupling between a Fuel Pump and a Direct Methanol Fuel Cell (2008)

Controlled experiments on a direct methanol fuel cell (DMFC) elucidate the effects of methanol flow rate and current density on pressure drop across the DMFC anode. A novel experimental technique is developed to measure void fraction, liquid slug length, and velocity of the slug/annular two phase flow exiting a DMFC anode. For the explored channel geometry, hydraulic diameter (Dh) of 600 microns, pressure drop scales with the number of slug/bubble interfaces, surface tension, and Dh. We present an empirical correlation of more than 160 measurements to aid in predicting pressure drop for DMFCs of similar scale. This work will aid in the design of fuel pumps for miniature DMFC systems.
Oxygen sensing tools for the improved assessment of hypoxia-related conditions (2021)

We have developed different portable tools based on phosphorescence lifetime and intensity measurements to be used together with syringes, needles, and catheters to measure oxygen partial pressure deep inside tissue with the aim to improve the assessment of acute compartment syndrome (ACS). Due to their portability and universality, the tools will also be useful in other hypoxia-related conditions such as vascular diseases, diabetic wounds, cancer, and traumatic injuries. We will present designs as well as results from in vivo porcine model studies.
Analysis of mutual coupling between two transverse dipoles series-fed electromagnetically-coupled (1992)

A rigorous analysis of the mutual coupling admittance between two transverse series-fed dipoles by proximity-coupled versus element spacing is presented. A comparison between measurements and theory has shown good agreement. Thus, this method of calculation, considering the radiating elements as a two-port model, can be included in a synthesis of a linear array of microstrip antennas electromagnetically series-fed; this type of array is more easily manufactured than a microstrip array electromagnetically parallel-fed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Substrate Nitridation Effects on GaN Grown on GaAs Substrates by Molecular Beam Epitaxy Using RF-Radical Nitrogen Source (1994)

The initial substrate nitridation effects on the crystal structure of GaN epitaxial layers grown on GaAs substrates by gas source molecular beam epitaxy using RF-radical N 2 as a nitrogen source were investigated. The crystal structure of GaN grown on (100) GaAs substrates was critically influenced by substrate nitridation time, that is, zincblende GaN was grown on the substrate without nitridation, and wurtzite GaN was grown on the nitrided substrate (longer than 120 s). The substrate misorientation effects on surface morphology and X-ray full width at half-maximum of zincblende GaN layers were also studied. A featureless smooth surface was obtained for a layer grown under the high V/III beam flux ratio condition.
The Pathognomonic FOXL2 C134W Mutation Alters DNA-Binding Specificity (2020)

The somatic missense point mutation c.402C>G (p.C134W) in the FOXL2 transcription factor is pathognomonic for adult-type granulosa cell tumors (AGCT) and a diagnostic marker for this tumor type. However, the molecular consequences of this mutation and its contribution to the mechanisms of AGCT pathogenesis remain unclear. To explore these mechanisms, we engineered V5-FOXL2<sup>WT</sup>- and V5-FOXL2<sup>C134W</sup>-inducible isogenic cell lines and performed chromatin immunoprecipitation sequencing and transcriptome profiling. FOXL2<sup>C134W</sup> associated with the majority of the FOXL2 wild-type DNA elements as well as a large collection of unique elements genome wide. This model enabled confirmation of altered DNA-binding specificity for FOXL2<sup>C134W</sup> and identification of unique targets of FOXL2<sup>C134W</sup> including <i>SLC35F2</i>, whose expression increased sensitivity to YM155. Our results suggest FOXL2<sup>C134W</sup> drives AGCT by altering the binding affinity of FOXL2-containing complexes to engage an oncogenic transcriptional program. SIGNIFICANCE: A mechanistic understanding of FOXL2<sup>C134W</sup>-induced regulatory state alterations drives discovery of a rationally designed therapeutic strategy.
Intuitive and Efficient Human-robot Collaboration via Real-time Approximate Bayesian Inference (2022)

The combination of collaborative robots and end-to-end AI, promises flexible automation of human tasks in factories and warehouses. However, such promise seems a few breakthroughs away. In the meantime, humans and cobots will collaborate helping each other. For these collaborations to be effective and safe, robots need to model, predict and exploit human's intents for responsive decision making processes. Approximate Bayesian Computation (ABC) is an analysis-by-synthesis approach to perform probabilistic predictions upon uncertain quantities. ABC includes priors conveniently, leverages sampling algorithms for inference and is flexible to benefit from complex models, e.g. via simulators. However, ABC is known to be computationally too intensive to run at interactive frame rates required for effective human-robot collaboration tasks. In this paper, we formulate human reaching intent prediction as an ABC problem and describe two key performance innovations which allow computations at interactive rates. Our real-world experiments with a collaborative robot set-up, demonstrate the viability of our proposed approach. Experimental evaluations convey the advantages and value of human intent prediction for packing cooperative tasks. Qualitative results show how anticipating human's reaching intent improves human-robot collaboration without compromising safety. Quantitative task fluency metrics confirm the qualitative claims.
Efficacy of an Acellular Pertussis Vaccine among Adolescents and Adults (2005)

The acellular pertussis vaccine was protective among adolescents and adults, and its routine use might reduce the overall disease burden and transmission to children.
Bisphosphonate drugs have actions outside the skeleton and inhibit the mevalonate pathway in alveolar macrophages (2021)

ABSTRACT Bisphosphonates drugs target the skeleton and are used globally for the treatment of common bone disorders. Nitrogen-containing bisphosphonates act by inhibiting the mevalonate pathway in bone-resorbing osteoclasts but, surprisingly, also appear to reduce the risk of death from pneumonia. We overturn the long-held belief that these drugs act only in the skeleton and show that a fluorescently-labelled bisphosphonate is internalised by alveolar macrophages and peritoneal macrophages in vivo . Furthermore, a single dose of a nitrogen-containing bisphosphonate (zoledronic acid) in mice was sufficient to inhibit the mevalonate pathway in tissue-resident macrophages, causing the build-up of a mevalonate metabolite and preventing protein prenylation. Importantly, one dose of bisphosphonate enhanced the immune response to bacterial endotoxin in the lung and increased the level of cytokines and chemokines in bronchoalveolar fluid. These studies suggest that bisphosphonates, as well as preventing bone loss, may boost immune responses to infection in the lung and provide a mechanistic basis to fully examine the potential of bisphosphonates to help combat respiratory infections that cause pneumonia.
Localization Method for Autonomous Vehicles by using Vertical Elements in the Environment (2019)

RoboCity2030-DIH-CM, Madrid Robotics Digital Innovation Hub, S2018/NMT-4331, funded by R&D Activities Program in
Comunidad de Madrid and cofunded by EU Structural Funds.