gebhart/patrepeval huggingface dataset:
Competitive Mean-Squared Error Beamforming (2004)

We consider the problem of designing a linear beamformer to estimate a source signal s(t) from array observations. Conventional beamforming methods typically aim at maximizing the signal-to-interference-plus-noise ratio (SINR). However this does not guarantee a small mean-squared error (MSE), hence on average their resulting signal estimate ^s(t) can be far from s(t). To ensure that ^s(t) is close to s(t), we propose using the more appropriate design criterion of MSE. Since the MSE depends in general on s(t) which is unknown, it cannot be minimized directly. Therefore we develop a competitive beamforming approach, in which the beamformer is designed to minimize the worst-case regret over all s(t), where the regret is the difference between the MSE using a beamformer ignorant of s(t) and the smallest possible MSE attainable with a beamformer that knows s(t). Thus, we ensure that over a wide range of signal values, our beamformer will result in a relatively low MSE. We demonstrate through numerical examples that the proposed minimax regret beamformer (MMR) outperforms several existing standard and robust beamformers, for wide range of SNR values.
Supplementary Figure S3 from Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition (2023)

&lt;p&gt;Combined treatment of AR-42 and KPT-9274 leads to mitochondrial potential collapses in cell lines.&lt;/p&gt;
Intel Corporation—Intel IXP2400 Network Processor: A Second-Generation Intel NPU (2003)

Next generation access and edge equipment requires flexible programming, high performance, low power consumption, and small real estate. In context to this, Intel has developed a next-generation network processor, the IXP2400, which is optimized to meet these requirements. The Intel IXP2400 network processor delivers a new level of intelligence and performance for access and edge applications, enabling the realization of quality of service (QoS), enforcement of service-level agreements (SLAs), and traffic engineering at OC-48/2 .5 Gbps and 4 Gbps data rates. The flexible media interface allows a variety of media devices, ranging from OC3 to OC48 speeds to be connected without logic to the IXP2400 for easier design and lower system cost. These capabilities essentially allow OEMs and service providers to offer differentiated and tiered services to their customers while efficiently managing their network resources and bandwidth. The performance and flexibility of the IXP2400 makes it desirable for a wide variety of high-performance applications such as multiservice switches, DSLAMs (DSL access multiplexers), CMTS (cable modem termination system) equipment, 2.5G and 3G wireless infrastructure, and layer 4-7 switches.
Iron(II)‐Catalyzed Trifluoromethylation of Potassium Vinyltrifluoroborates (2012)

Exchanging BF3 by CF3: The title reaction proceeds under exceedingly mild reaction conditions and provides 2-arylvinyl- and 2-heteroarylvinyl-substituted substrates with E/Z selectivities of more than 95:5. Experimental observations suggest that the reaction does not proceed through a transmetalation of the RBF3K species to the iron catalyst. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Virtual Gutenberg’s Printing Press (2002)

The exhibit installation “Virtual Gutenberg’s Printing Press” helps people to understand the Gutenberg’s invention using State-of-the-Art augmented reality technology. The functionality of the Gutenberg’s printing press is shown in a user-friendly way, with presentation technology completely hidden from visitor experience and using real objects as user interface. Visitors can simulate the book printing using only real world objects such as tweezers, letter case, coloring unit, and printing press. The installation consists of three main stations – setting, coloring and printing. Additionally there is a huge display in front of the stations showing the whole process using stereo projection. The main idea is to show the people, living in an information era, the principle of the invention that made it possible to widely distribute information for the first time – the book printing.
Study on Ce:LiCAF scintillator for3He alternative detector (2012)

Neutrons are used as a probe on a large scale in a variety of scattering types, e.g. diffraction and reflection, for the study of structure and dynamics of materials not only for materials science,...
Cryogenic Lorentz TEM study of a Berezinskii–Kosterlitz–Thouless phase transition in the quasi-two-dimensional ferromagnet K2CuF4? (2021)

The dimensionality of a system has a strong influence on its structure and dynamics. Indeed, the nature of the phase transition in a low-dimensional system has attracted considerable interest for many decades. One of the celebrated works in the field is the proposal of the topological ground state in the twodimensional (2D) spin system, which was made by Kosterlitz and Thouless [1] and awarded the Nobel Prize in Physics 2016.
Genetic liability to osteoarthritis may be greater in women than men (1996)

EDITOR,—Tim D Spector and colleagues report a study of genetic influences on osteoarthritis in monozygotic and dizygotic female twins.1 They conclude that their results show a clear genetic effect for radiographic osteoarthritis of the hand and knee in women (ranging from 39% to 65%) independent of known environmental or demographic confounders. In his commentary on the paper John Hopper states that these figures must be considered to be an upper bound of the genetic influence.1

In a questionnaire sent to the Finnish twin cohort …
The effect of end to end latency in a distributed storage area network on Microsoft Exchange Server 2003 performance - Part I (2004)

The ever increasing demand for fast and reliable data storage has caused dramatic changes in the storage model. The direct attached storage (DAS) model is being replaced by storage area networks (SANs). SANs provide the capability to distribute the storage across multiple servers leading to decentralized and externalized storage. Recently, the accessibility of SANs to small companies has been improved by using existing IP networks to distribute storage over long geographical distances, leading to the distributed storage area network (DSAN). Although DSANs have provided additional capabilities to SANs, they have created a new set of problems for enterprise class applications, like Microsoft Exchange Server 2003, with increasing end to end latency (ETEL), due to large physical cable lengths. We present an attempt to analyze the effect of ETEL in DSAN on the performance of Microsoft Exchange Server 2003 by monitoring the Exchange behavior using LoadSim 2003 benchmark.
Starting with termination: a methodology for building distributed garbage collection algorithms (2002)

We propose an effective methodology in which a distributed garbage collector may be derived from a distributed termination algorithm and a centralized garbage collector in a manner that preserves interesting properties of the original collector, such as completeness. To illustrate our technique, we show how two distributed termination algorithms, credit recovery and task balancing, may be suitably described; and then map four centralized garbage collectors: reference counting; mark/scan; a generational scheme; and the Mature Object Space collector (MOS) onto this description. The advantage of our approach is that by separating the issues of distribution and collection, we alleviate the difficulty of inventing, understanding, and comparing distributed garbage collection techniques.
A localized differentiation-inducing-factor sink in the front of the Dictyostelium slug. (1993)

Differentiation-inducing factor 1 [DIF-1; 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)-hexan-1-one] induces stalk cell differentiation during Dictyostelium development. It is present as a gradient in the multicellular slug, its lowest concentration being in the anterior. Here we demonstrate the existence of a localized sink for DIF-1, also in the anterior of the slug, which could be responsible for generating the DIF-1 gradient. DIF-1 is metabolized extensively by developing cells, initially by a mono-dechlorination. We used an enzyme assay for DIF-1 dechlorinase to examine its distribution in the slug. DIF-1 dechlorinase activity is 30-fold higher in prestalk cells (largely anterior) compared with prespore cells (posterior) when these are separated from each other on Percoll density gradients. Dissection experiments showed that DIF-1 dechlorinase is 25-fold enriched in the anterior 13% of the slug compared with the rest. These experiments also showed that DIF-1 dechlorinase is more anterior-enriched than the standard prestalk markers, the ecmA and ecmB mRNAs. When cut from a slug, both prestalk and prespore fragments regulate to restore the missing cell type. Prespore fragments rapidly regain (by 30 min) a DIF-1 sink in their anteriors, and prestalk fragments restore a posterior zone with low DIF-1 dechlorinase by 4 hr after cutting. The reappearance of the DIF-1 sink in the anterior of prespore fragments is accomplished without detectable cell sorting and may, therefore, be in response to positional signals. Finally, a localized sink may provide a general way of producing a gradient of a signal substance in a developing embryo.
Tractor pulling on data warehouses (2011)

Robustness of database systems under stress is hard to quantify, because there are many factors involved, most notably the user expectation to perform a job within certain bounds of the user requirements. Nevertheless, robustness of database system is very important to end users. In this paper we develop a database benchmark suite, inspired by tractor pulling, where robustness is measured as a system's ability to process data despite a continuous increase in system load, as defined in terms of data volume, query volume and complexity. A functional evaluation is performed against several systems to highlight the benchmark capabilities.
Swarm control of cell-based microrobots using a single global magnetic field (2013)

Tetrahymena pyriformis is a single cell eukaryote that can be modified to respond to magnetic fields, a response called magnetotaxis. In experiments, a rotating field is applied to cells using a two dimensional approximate Helmholtz system. Using rotating magnetic fields, we characterize discrete cells' swarm swimming which is affected by several factors. The behavior of the cells under these fields is explained in detail. After the field is removed, relatively straight swimming is observed. By exploiting this straight swimming behavior, we propose a method to control discrete cells utilizing a single global input. Successful implementation of this swarm control method would enable teams of microrobots to perform a variety of microscale tasks impossible for single microrobots, such as pushing objects or simultaneous micromanipulation of discrete entities.
Refractory Photosensitive Epilepsy Associated with a Complex Rearrangement of Chromosome 2 (2003)

We describe the relevant clinical and therapeutic parameters in a single patient with a complex chromosome 2 abnormality presenting with refractory myoclonic photosensitive epilepsy. FISH technology using yeast artificial chromosomes (YACs) was employed to determine breakage points, microdeletions and inversions on the affected chromosome. In this patient with refractory photosensitive epilepsy, 12 breakpoints and one small inversion were identified on the abnormal chromosome 2. Our data can be used in further genetic studies on the exact location and identification of photosensitivity genes.
Supplementary Table 2 from Integrative Analysis of Genomic Aberrations Associated with Prostate Cancer Progression (2023)

Supplementary Table 2 from Integrative Analysis of Genomic Aberrations Associated with Prostate Cancer Progression
Mechanistic proposal for asparagine-linked glycosylation (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanistic proposal for asparagine-linked glycosylationB. Imperiali, K. L. Shannon, M. Unno, and K. W. RickertCite this: J. Am. Chem. Soc. 1992, 114, 20, 7944–7945Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/ja00046a069https://doi.org/10.1021/ja00046a069research-articleACS PublicationsRequest reuse permissionsArticle Views368Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Anti-PD1/PD-L1 Immunotherapy for Non-Small Cell Lung Cancer with Actionable Oncogenic Driver Mutations (2021)

Anti-PD1/PD-L1 immunotherapy has emerged as a standard of care for stage III-IV non-small cell lung cancer (NSCLC) over the past decade. Patient selection is usually based on PD-L1 expression by tumor cells and/or tumor mutational burden. However, mutations in oncogenic drivers such as <i>EGFR</i>, <i>ALK</i>, <i>BRAF</i>, or <i>MET</i> modify the immune tumor microenvironment and may promote anti-PD1/PD-L1 resistance. In this review, we discuss the molecular mechanisms associated with these mutations, which shape the immune tumor microenvironment and may impede anti-PD1/PD-L1 efficacy. We provide an overview of the current clinical data on anti-PD1/PD-L1 efficacy in NSCLC with oncogenic driver mutation.
Analysis of five deep-sequenced trio-genomes of the Peninsular Malaysia Orang Asli and North Borneo populations (2019)

Our study presents a full catalogue of the genome variants of the native Malaysian populations, which is a complement of the genome diversity in Southeast Asians. It implies specific population history of the native inhabitants, and demonstrated the necessity of more genome sequencing efforts on the multi-ethnic native groups of Malaysia and Southeast Asia.
Seismic Diffraction Response from Boreholes (2016)

Summary Borehole diameters are typically much smaller than the dominant seismic wavelength and near-vertical borehole geometries do not favor reflection response at a surface acquisition. For these reasons - resolution and illumination - we study the diffraction response from boreholes on surface seismic data. Diffractions from boreholes are observable on surface seismic data under certain relatively mild conditions (sufficient frequency content, signal-to-noise and impedance contrast between the borehole and surrounding rock), and can be used to trace its trajectory. This is the objective of Surface Seismic monitoring While Drilling. In particular, we show that organizing the diffraction imaging in a time-lapse and target-oriented fashion can result in a very efficient and accurate way of monitoring the borehole during drilling.
The effect of block copolymer architecture on the coalescence and interfacial elasticity in compatibilized polymer blends (2005)

The effect of block copolymer architecture on the suppression of droplet coalescence and on the interfacial elasticity was studied in immiscible blends of polydimethylsiloxane (PDMS) and polyisoprene (PI) with a droplet-matrix morphology. The PDMS-PI diblock copolymers used in this study to compatibilize the blends differ in molecular weight and degree of asymmetry of the blocks. The general Palierne model with an interfacial shear modulus was used to analyze the dynamic measurements performed after different shear histories. It was shown that the coalescence suppression is more effective when the amount of compatibilizer increases and when the overall molecular weight of the block copolymer increases. When comparing the coalescence behavior of a blend and the inverse blend, it was shown that coalescence is suppressed more when the longest block of the block copolymer is located in the matrix. The interfacial relaxation time increases with molecular weight of the blocks for symmetric block copolymers. Asymmetry of the blocks also causes it to increase. A scaling relation is proposed for the interfacial relaxation time of PI/PDMS blends. This master curve is extended for varying viscosity ratios of the blend and with data of a polydimethylsiloxane (PDMS)/polyisobutylene (PIB) blend and a polymethylmethacrylate (PMMA)/polystyrene (PS) blend.
Data-centric Web Services Based on Business Artifacts (2012)

Existing Web services standards consider data primarily on the level of inputs and outputs specifications, with the major focus on functional aspects of interactions. Majority of applications rely on data sources, but such data sources are not part of the Web service specifications and cannot be accessed directly by clients. The fact that data are treated independently or as second-class citizens severely limits re-use, flexibility, customization and integration options of current Web services. In this paper we suggest to extend the WS specifications by introducing a data-centric Web services model that integrates functional and data perspectives in one coherent framework. The approach is based on Business Artifacts and in particular on the declarative modular Guard-Stage-Milestone (GSM) model. We introduce a Web Data- and Artifact- centric Service (W-DAS) model using GSM in its core which in addition to usual application specific WS operations defines a set of data access interfaces including CRUD operations, artifacts retrieval interface for querying, filtering and sorting data, and operations for arbitrary custom defined ad hoc run-time queries. We discuss W-DAS publish-subscribe mechanisms and implementation.
Time-reversal of waves near critical angle on a liquid–solid interface (2004)

When sending a plane ultrasonic wave towards a liquid–solid interface, the reflected wave is affected, depending on the attack angle. In particular, when ultrapassing the critical tranverse angle, the reflection coefficient becomes complex, which in practice has the effect of dephasing the reflected wavefront. If this reflected wave is time-reversed and sent back towards the interface, the reflected wave of this time-reversed wave should not present this dephasing, as the time-reversal process restores the original phases. A theoretical and experimental study of these phenomena has been done. The dephasing of the reflected waves when passing the critical angle is observed, and as expected the signals after time-reversal are in phase. Nevertheless, a significant attenuation of the time-reversed signal is observed for attack angles around the critical transverse angle, as energy goes with the transmitted wave, which is not time-reversed. In a second part, it is shown by simulations and experiments how the fact of working at critical angle influences focusing of waves, by time-reversal or simple time-delays methods.
OTX2 homeoprotein functions in adult choroid plexus (2021)

Abstract Choroid plexus secretes cerebrospinal fluid important for brain development and homeostasis. The OTX2 homeoprotein is critical for choroid plexus development and remains highly expressed in adult choroid plexus. Through RNA sequencing analyses of constitutive and conditional knockdown adult mouse models, we reveal putative roles for OTX2 in choroid plexus function, including cell signaling and adhesion, and show that it regulates the expression of factors secreted into cerebrospinal fluid, notably transthyretin. We show that Otx2 expression impacts choroid plexus immune and stress responses, and also affects splicing which leads to changes in mRNA isoforms of proteins implicated in oxidative stress response and DNA repair. Through mass spectrometry analysis of OTX2 protein partners in the choroid plexus, and in known non-cell autonomous target regions such as visual cortex and ventricular-subventricular zone, we identified putative targets involved in cell adhesion, chromatin structure and RNA processing. Thus, OTX2 retains important roles in choroid plexus function and brain homeostasis throughout life.
Bayesian Matrix Completion via Adaptive Relaxed Spectral Regularization (2015)

Bayesian matrix completion has been studied based on a low-rank matrix factorization formulation with promising results. However, little work has been done on Bayesian matrix completion based on the more direct spectral regularization formulation. We fill this gap by presenting a novel Bayesian matrix completion method based on spectral regularization. In order to circumvent the difficulties of dealing with the orthonormality constraints of singular vectors, we derive a new equivalent form with relaxed constraints, which then leads us to design an adaptive version of spectral regularization feasible for Bayesian inference. Our Bayesian method requires no parameter tuning and can infer the number of latent factors automatically. Experiments on synthetic and real datasets demonstrate encouraging results on rank recovery and collaborative filtering, with notably good results for very sparse matrices.
Education Column (2012)

This issue's column includes a final report on research carried out by Asimina Kiourti with support from an AP-S Doctoral Research Award, a footnote from John Mahoney to his recent article on gain formulas, winners of AP-S Research Awards from the April 2011 round, and a technical contribution from José Pereira and Pedro Pinho on bandwidth analysis using the Smith chart.
SWAMP: an IoT-based Smart Water Management Platform for Precision Irrigation in Agriculture (2018)

Irrigation for agriculture is the biggest consumer of freshwater in the world, which makes a case for the intensive use of technology to optimize the use of water, reduce the consumption of energy and improve the quality of crops. While the Internet of Things (IoT) and other associated technologies are the natural choice for smart water management applications, their appropriateness is still to be proven in real settings with the deployment of on-site pilots. Also, IoT-based application development platforms should be generic enough to be adapted to different crops, climates, and countries. The SWAMP project develops IoT based methods and approaches for smart water management in precision irrigation domain and pilots them in Italy, Spain, and Brazil. In this paper, we present the SWAMP view, architecture, pilots and the scenario-based development process adopted in the project.