gebhart/patrepeval huggingface dataset:
Monitoring of centrifugal pump operation by a frequency converter (2011)

Centrifugal pumps are widely used in industrial and municipal applications, and they are an important end-use application of electric energy. However, in many cases centrifugal pumps operate with a significantly lower energy efficiency than they actually could, which typically has an increasing effect on the pump energy consumption and the resulting energy costs. Typical reasons for this are the incorrect dimensioning of the pumping system components and inefficiency of the applied pump control method. Besides the increase in energy costs, an inefficient operation may increase the risk of a pump failure and thereby the maintenance costs. In the worst case, a pump failure may lead to a process shutdown accruing additional costs.&#13;\nNowadays, centrifugal pumps are often controlled by adjusting their rotational speed, which affects the resulting flow rate and output pressure of the pumped fluid. Typically, the speed control is realised with a frequency converter that allows the control of the rotational speed of an induction motor. Since a frequency converter can estimate the motor rotational speed and shaft torque without external measurement sensors on the motor shaft, it also allows the development and use of sensorless methods for the estimation of the pump operation. Still today, the monitoring of pump operation is based on additional measurements and visual check-ups, which may not be applicable to determine the energy efficiency of the pump operation.&#13;\nThis doctoral thesis concentrates on the methods that allow the use of a frequency converter as a monitoring and analysis device for a centrifugal pump. Firstly, the determination of energy-efficiency- and reliability-based limits for the recommendable operating region of a variable-speed-driven centrifugal pump is discussed with a case study for the laboratory pumping system. Then, three model-based estimation methods for the pump operating location are studied, and their accuracy is determined by laboratory tests. In addition, a novel method to detect the occurrence of cavitation or flow recirculation in a centrifugal pump by a frequency converter is introduced. Its sensitivity compared with known cavitation detection methods is evaluated, and its applicability is verified by laboratory measurements for three different pumps and by using two different frequency converters. &#13;\nThe main focus of this thesis is on the radial flow end-suction centrifugal pumps, but the studied methods can also be feasible with mixed and axial flow centrifugal pumps, if allowed by their characteristics.
Testing of automata system (2016)

The problem of testing of aggregate systems is considered. The system is described with an oriented graph of links. The nodes correspond to automata of the components and arcs correspond to simplex communication channels. The hypothesis of the links is assumed: the graph of links is static and the link structure is error-free. In each state, the automaton can accept and send multiple messages through incoming and outgoing arcs (at most one message through each arc). The goal of testing is to cover transitions of the automata reachable during the system work. It assumed that during testing it is possible to observe the state changes of automata and the messages on the arcs. A simplified system model with only one message circulating is considered at the beginning. On its example we show that the hypothesis on links allows considerably reduce the number of required testing actions from the multiplication of numbers of the component automata states to the sum of these numbers. If the numbers of states of all automata are equal, it gives exponential reduction of the number of test actions. Then the more general model is considered when the system can simultaneously contain multiple messages, but not more than one on each arc. A composition of the system automata is defined and the restrictions on automata making the system deterministic are described. An algorithm of test generation is proposed basing on test filtration generated for covering all transitions of the deterministic composition system. Test is rejected if it covers only such transitions of the components that are covered by the remaining tests. In conclusion, the directions of future research are described.
Examining sialic acid derivatives as potential inhibitors of SARS-CoV-2 spike protein receptor binding domain (2023)

Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has been the primary reason behind the COVID-19 global pandemic which has affected millions of lives worldwide. The fundamental cause of the infection is the molecular binding of the viral spike protein receptor binding domain (SP-RBD) with the human cell angiotensin-converting enzyme 2 (ACE2) receptor. The infection can be prevented if the binding of RBD-ACE2 is resisted by utilizing certain inhibitors or drugs that demonstrate strong binding affinity towards the SP RBD. Sialic acid based glycans found widely in human cells and tissues have notable propensity of binding to viral proteins of the coronaviridae family. Recent experimental literature have used N-acetyl neuraminic acid (Sialic acid) to create diagnostic sensors for SARS-CoV-2, but a detailed interrogation of the underlying molecular mechanisms is warranted. Here, we perform all atom molecular dynamics (MD) simulations for the complexes of certain Sialic acid-based molecules with that of SP RBD of SARS CoV-2. Our results indicate that Sialic acid not only reproduces a binding affinity comparable to the RBD-ACE2 interactions, it also assumes the longest time to dissociate completely from the protein binding pocket of SP RBD. Our predictions corroborate that a combination of electrostatic and van der Waals energies as well the polar hydrogen bond interactions between the RBD residues and the inhibitors influence free energy of binding.Communicated by Ramaswamy H. Sarma.
Effective use of prosody in parsing conversational speech (2005)

We identify a set of prosodic cues for parsing conversational speech and show how such features can be effectively incorporated into a statistical parsing model. On the Switchboard corpus of conversational speech, the system achieves improved parse accuracy over a state-of-the-art system which uses only lexical and syntactic features. Since removal of edit regions is known to improve downstream parse accuracy, we explore alternatives for edit detection and show that PCFGs are not competitive with more specialized techniques.
Raman Study of Hydrogenated and Fluorinated Single‐walled Carbon Nanotubes (2008)

Abstract Hydrogenated and fluorinated single‐walled carbon nanotubes (SWNT‐H and SWNT‐F) were investigated by micro‐Raman spectroscopy. The as‐prepared SWNT‐H exhibits giant structureless hot luminescence that screens the Raman peaks. The luminescence background, attributed to random binding of the hydrogen atoms, gradually decreases upon annealing of the sample. In contrast, the as‐prepared SWNT‐F shows no luminescence but the Raman peaks are rather broad. The annealing of SWNT‐F results in structural ordering due to fluorine removal. Keywords: Single‐walled carbon nanotubesRaman spectraHydrogenationfluorination ACKNOWLEDGMENTS The support by the Russian Foundation for Basic Research, grant No 08‐02‐00890, and the support of the General Secretariat for Research and Technology (Greece) and Russian Academy of Sciences under the bilateral Greek‐Russian collaboration program, are greatly acknowledged.
Iterative Soft Interference Cancelation for HSPA Uplink (2010)

Interference cancelation (IC) has been well studied in literature as a potential capacity approaching scheme for uplink code-division multiple-access (CDMA) systems. With the advance of silicon technology, it is becoming implementationally feasible. In this paper, we study a soft IC algorithm which could be iteratively concatenated with Turbo decoding. The algorithm only relies on a conventional single user Rake receiver. We study the IC efficiency as well as optimal soft decision methods. We compare different types of add-back operations between iterations. Finally we provide both link level as well as system level simulation results.
Experimental and Numerical Assessment of Chemical EOR in Oil-Wet Naturally-Fractured Reservoirs (2014)

Abstract Among various ways to extend the lifetime of mature fields, chemical EOR processes have been subject of renewed interest in the recent years. Oil-wet fractured reservoirs represent a real challenge for chemical EOR as the matrix medium does not spontaneously imbibe the aqueous solvent of chemical additives. However, a wide variety of surfactants can now be considered for EOR, among which products that alter the matrix wettability. The present paper deals with that recovery strategy and compares it with other strategies based on viscous drive enhancement. Comparison is based on the physical and numerical interpretation of original representative experiments. The kinetics of spontaneous imbibition of chemical solutions in oil-wet limestone plugs and mini-plugs has been quantified thanks to X-ray CT-scanning and NMR measurements. Despite the small size of samples and the slowness of experiments, accurate recovery curves could be inferred from in-situ fluid saturation measurements. Scale effects were found quite consistent between mini-plugs and plugs. During a second experimental step, representative drive conditions of a fractured reservoir were imposed between the end-faces of a plug, in order to account for the possibly-significant contribution of fracture viscous drive to matrix oil recovery. These experiments were carefully analyzed and their numerical modeling was initiated with a simulation software that takes into account the multiple effects of surfactant presence on rock-fluids systems, including rock wettability modification and water-oil interfacial tension reduction. Model capability to reproduce experimental results is quite satisfactory provided that the evolution of capillary pressures in the presence of additives is sufficiently characterized. A few sensitivity studies underline also the necessity of disposing of a completely-documented physico-chemical data set to minimize modeling uncertainties in view of reliable recovery kinetics optimization. In summary, the present paper provides an original quantitative description of chemical EOR process in neutral to oil-wet fractured reservoirs. This work calls for further development in order to specify the conditions on chemical additives and recovery process implementation that satisfy economic viability.
Locating Physical Interface Objects on Interactive Surfaces. (2006)

Pin&Play has enabled a new type of surface-based physical user interface, characterised by dynamic arrangement of interface objects on a surface area. Previous work has shown that this affords rapid re-arrangement of the spatial layout of interface objects, for example in adaptation to user preferences, but the Pin&Play system did not support tracking of object locations on the surface. In this paper, we investigate and compare two practical location techniques for interactive surfaces that are based on external sensing: detection of surface events using load sensors, and camera-based detection using object beacons.
OUTC-05. DIFFERENCES IN FACTORS INFLUENCING SURVIVAL IN CHILDHOOD AND ADULT CNS MALIGNANCIES (2023)

Abstract Socioeconomic factors such as income and community type have shown to correlate with outcomes in neuro-oncologic care. In pediatric populations, however, fewer conclusions have been drawn on the effects of factors such as race, gender, and insurance status on survival due to the relative rarity of such cases. This analysis utilizes the National Cancer Institute’s Surveillance, Epidemiology and End Results (SEER) program database to determine differences in factors influencing survival in both pediatric and adult CNS malignancies. From the SEER Research Nov 2020 (1975-2018) dataset, 29865 patients with malignant CNS tumors (identified by ICD-0-3 code) diagnosed between 1990-2018 and directly causing patient demise were selected and data were collected on age at diagnosis, sex, race, median household income (in 2019 USD), community type (rural-urban continuum), and survival (in months). This cohort was separated into pediatric (ages 0-19, n = 1509) and adult (ages 20 and above, n = 28356) subgroups and independent survival analysis was conducted by income, community type, sex, race, and decade of diagnosis. Kaplan-Meier curves were visualized for each comparison. Log rank analysis of survival in the pediatric cohort showed greater mortality in females (p = 0.0224) and in the most recent decade (p &amp;lt; 0.0001). The same analysis in the adult cohort showed greater mortality in lower income groups, more rural community settings, females, patients categorized as White, and in the most recent decade (p &amp;lt; 0.0001 for all comparisons). Unlike in the adult population, income, community setting, and race were not associated with significant differences in survival in the pediatric population, prompting further investigation into healthcare delivery differences between pediatric and adult populations. Further study should focus on the cause of these discrepancies to improve equity in neurosurgical care.
Myeloperoxidase-derived Hypochlorous Acid Antagonizes the Oxidative Stress-mediated Activation of Iron Regulatory Protein 1 (2003)

Hypochlorous acid (HOCl) is a highly reactive product generated by the myeloperoxidase reaction during the oxidative burst of activated neutrophils, which is implicated in many bactericidal and cytotoxic responses. Recent evidence suggests that HOCl may also play a role in the modulation of redox sensitive signaling pathways. The short half-life of HOCl and the requirement for a continuous presence of H2O2 as a substrate for its myeloperoxidase-catalyzed generation make the study of HOCl-mediated responses very difficult. We describe here an enzymatic model consisting of glucose/glucose oxidase, catalase, and myeloperoxidase (GOX/CAT/MPO) that allows the controlled generation of both HOCl and H2O2 and thus, mimics the oxidative burst of activated neutrophils. By employing this model we show that HOCl prevents the H2O2-mediated activation of iron regulatory protein 1 (IRP1), a central post-transcriptional regulator of mammalian iron metabolism. Activated IRP1 binds to (R)iron-responsive elements" (IREs) within the mRNAs encoding proteins of iron metabolism and thereby controls their translation or stability. The inhibitory effect of HOCl is not a result of a direct modification of IRP1 by this oxidant. Kinetics experiments provide evidence that HOCl intervenes with the signaling cascade, which results in the activation of IRP1. We further demonstrate that HOCl antagonizes the H2O2-mediated increase in the levels of transferrin receptor, which is a downstream target of IRP1. Our findings suggest that HOCl can modulate signaling pathways in a concerted action with H2O2. The GOX/CAT/MPO system provides a valuable tool for studying the regulatory function of HOCl.
Call for Proposals [2021 IEEE Radar Conference (RadarConf21) (2017)

The Radar Systems Panel (RSP) of the IEEE Aerospace & Electronic Systems Society welcomes proposals from prospective organizers to host the 2021 IEEE Radar Conference. This conference series, originally initiated in 1984 at the US National Radar Conference, has grown to have an internationally diverse attendance and a reputation for the highest quality. The RadarConf series is the premier forum for the technological advancement of the field of radar including theoretical and experimental results for a diverse array of civil, scientific, and defense applications.
On John Biggers (2014)

I first met John Biggers outside Foyle's Bookshop in London, in 1979. The background to this meeting was that I was a new Lecturer (Assistant Professor) at York University in the UK and my senior p...
Evaluation of Liquid Topical Antimicrobials for Use in Austere Environments (2006)

In order to improve the care given to patients in austere environments, we have conducted research to identify and test liquid topical antimicrobials. Though well proven in efficacy, antimicrobial creams are difficult to use in austere environments for numerous reasons. In order to rigorously test these agents, we used the Walker-Mason rat scald model with a 20% TBSA full thickness injury inoculated with P. aeurginosa. The maturity of products assessed included agents with FDA approval for other indications as well as candidates in various stages of pre-clinical testing. Here we report the results of this testing to date, and the trends observed when testing various agents in this established model. Antimicrobials were obtained from commercial sources if available, or by materials transfer agreement with the developer when required. Agents tested were: 85mg/g Mafenide Acetate Cream, 5% Mafenide Acetate Solution, 5% Mafenide HCl solution, 1%, 5% and 10% Proprietary Antimicrobial Compound...
Inosine to Increase Serum and Cerebrospinal Fluid Urate in Parkinson Disease (2014)

clinicaltrials.gov Identifier: NCT00833690.
<title>Holographic display of computer simulations</title> (1991)

Computer simulations can generate massive quantities of data. One problem for scientists and engineers is to assimilate and place in perspective the information available from the simulation and to communicate this information to other interested parties. The authors have been exploring some novel holographic display formats that provide hardcopy output of the results of computer simulations. These holograms allow rapid survey of graphical data as well as an opportunity to examine specific results. The hologram is more portable than a graphics workstation and is easily reproduced for wide distribution. The authors describe some of the holographic techniques, make some comments on pictorial presentation of data, and illustrate these points with examples from fluid dynamics, fracture mechanics, and architecture.
Prognose nach Knollenblätterpilzintoxikation – eine prospektive Fallserie (2014)

Ziel ist der Vergleich gängiger Prognoseparameter mit der tatsächlichen Überlebenswahrscheinlichkeit.
19.1: Invited Paper : Printing Processes for the Vacuum Free Manufacture of Liquid Crystal Cells with Plastic Substrates (2000)

Abstract Printing processes for etch resist, alignment layer, glue and also nematic and ferrorelectric LCs are presented. Special care is taken to print the FLC with the desired alignment. A comparison between knife coating with a doctor blade as well as flexographic and inkjet printing will be offered.
Chemistry in supercritical fluids for the synthesis of metal nanomaterials (2019)

The supercritical flow synthesis of metal nanomaterials is sustainable and scalable for the efficient production of materials.
Computer‐Generated Diagnostic Diagrams for Pacemaker Rhythm Analysis and Pacing System Evaluation (1987)

An automatic computer generated Pacemaker Diagnostic Diagram described previously (PACE 8:691) was plotted below the ECG to aid the diagnosis of complex pacemaker‐heart interaction. During routine followup visits, 14 patients with Symbios 7005 or 7006 DDD pacemakers were studied during various temporary programming protocols to demonstrate common and unusual pacemaker problems. The examples discussed in this paper explain how the side‐by‐side ECG and diagram synergistically aid human diagnosis of undersensing, oversensing, loss of capture in either or both chambers, upper rate limiting, safety pacing and atrial arrhythmias. The Pacemaker Diagnostic Diagram was a useful clinical too! especially for analysis of complex pacemaker arrhythmias.
On The Usage of Gaussian Processes for Visible Light Positioning With Real Radiation Patterns (2021)

In this work the performance of a two dimensional, Received Signal Strength-based Visible Light Positioning strategy using multilateration, that assumes ideal Lambertian radiation patterns, is compared to a data-based machine learning strategy that uses Gaussian Process regression to perform localization. The results are obtained from a simulation framework that leverages the accurately measured radiation patterns of four off-the-shelf LEDs, which are specified by the manufacturer to be Lambertian sources. The main results are that when using the idealized Lambertian model for localization a significant bias is introduced with a p95 error of up to 14.1 cm, while the data-based approach using a Gaussian Process for localization proves to be much better suited, delivering a p95 error of 1.26 cm in the best performing considered scenario.
SU-G-201-15: Nomogram as an Efficient Dosimetric Verification Tool in HDR Prostate Brachytherapy (2016)

Purpose: Nomogram as a simple QA tool for HDR prostate brachytherapy treatment planning has been developed and validated clinically. Reproducibility including patient-to-patient and physician-to-physician variability was assessed. Methods: The study was performed on HDR prostate implants from physician A (n=34) and B (n=15) using different implant techniques and planning methodologies. A nomogram was implemented as an independent QA of computer-based treatment planning before plan execution. Normalized implant strength (total air kerma strength Sk*t in cGy cm2 divided by prescribed dose in cGy) was plotted as a function of PTV volume and total V100. A quadratic equation was used to fit the data with R2 denoting the model predictive power. Results: All plans showed good target coverage while OARs met the dose constraint guidelines. Vastly different implant and planning styles were reflected on conformity index (entire dose matrix V100/PTV volume, physician A implants: 1.27±0.14, physician B: 1.47±0.17) and PTV V150/PTV volume ratio (physician A: 0.34±0.09, physician B: 0.24±0.07). The quadratic model provided a better fit for the curved relationship between normalized implant strength and total V100 (or PTV volume) than a simple linear function. Unlike the normalized implant strength versus PTV volume nomogram which differed between physicians, a unique quadratic model based nomogram (Sk*t)/D=−0.0008V2+0.0542V+1.1185 (R2=0.9977) described the dependence of normalized implant strength on total V100 over all the patients from both physicians despite two different implant and planning philosophies. Normalized implant strength - total V100 model also generated less deviant points distorting the smoothed ones with a significantly higher correlation. Conclusion: A simple and universal, excel-based nomogram was created as an independent calculation tool for HDR prostate brachytherapy. Unlike similar attempts, our nomogram is insensitive to implant style and does not rely on reproducing dose calculations using TG-43 formalism, thus making it a truly independent check.
Accumulation of high molecular weight kininogen in the brains of Alzheimer's disease patients may affect microglial function by altering phagocytosis and lysosomal cathepsin activity (2022)

Increased activation of the contact system protein high molecular weight kininogen (HK) has been shown in plasma and cerebrospinal fluid of Alzheimer's disease (AD) patients, but its potential role in the brain has not been explored. We assessed HK levels in brain tissue from 20 AD patients and controls and modeled the effects of HK on microglia-like cells in culture. We show increased levels of HK in the hippocampus of AD patients, which colocalized with amyloid beta (Aβ) deposits and activated microglia. Treatment of microglia with HK led to cell clustering and elevated levels of phagocytosed Aβ. We demonstrate that microglia internalize HK and traffic it to lysosomes, which is accompanied by reduced activity of lysosomal cathepsins L and S. Our results suggest that HK accumulation in the AD hippocampus may alter microglial uptake and degradation of Aβ fibrils, possibly contributing to microglial dysfunction in AD.