gebhart/patrepeval huggingface dataset:
New Technical Resource for Induction Heat Treating Professionals (2015)

Abstract The recently published ASM Handbook, Volume 4C is specifically devoted to meeting the needs of the induction heating and heat treating community. It is a long-awaited expansion of the ASM Handbook series to cover induction technology in depth. Heating by electromagnetic induction is a topic of major technological significance that continues to grow at an accelerated rate in a variety of thermal applications such as hardening, tempering, stress relieving, brazing, soldering, shrink fitting, melting, normalizing, annealing, coating, as well as re-heating ferrous and non-ferrous metallic materials prior to warm and hot working. The new ASM Handbook volume reflects an ambitious undertaking to compile an all-new, comprehensive resource on 21st-century induction thermal processes. World-recognized experts from leading universities, national research laboratories, and industrial corporations from 10 countries contributed to this volume, making it a truly international work to address leading-edge induction technologies.
The Structures of COPI-Coated Vesicles Reveal Alternate Coatomer Conformations and Interactions (2012)

Transport between compartments of eukaryotic cells is mediated by coated vesicles. The archetypal protein coats COPI, COPII, and clathrin are conserved from yeast to human. Structural studies of COPII and clathrin coats assembled in vitro without membranes suggest that coat components assemble regular cages with the same set of interactions between components. Detailed three-dimensional structures of coated membrane vesicles have not been obtained. Here, we solved the structures of individual COPI-coated membrane vesicles by cryoelectron tomography and subtomogram averaging of in vitro reconstituted budding reactions. The coat protein complex, coatomer, was observed to adopt alternative conformations to change the number of other coatomers with which it interacts and to form vesicles with variable sizes and shapes. This represents a fundamentally different basis for vesicle coat assembly.
Environmental aging of epoxy based stereolithography Part 2 – Effect of absorbed moisture on mechanical properties (2012)

The first part of this paper demonstrated how the quasi-Fickian moisture uptake exhibited by stereolithography resins could be modelled. This part outlines the effect of moisture absorption on the mechanical properties of one of the materials. Fickian and dual Fickian diffusion models, using both analytical and finite element analysis (FEA) techniques, were used to model the moisture uptake in aged samples. Uniaxial tensile testing of dog bone samples revealed a decrease in elastic modulus and yield stress and an increase in strain to failure with increased moisture content. A model has been developed to predict the change in stiffness of aged samples over time. The results produced from this model show a good correlation with the experimental data and FEA predictions. It is proposed that FEA based coupled stress diffusion analysis methods can be used to predict the effect of moisture on the mechanical performance of parts made by stereolithography when used in service.
Protein Functionality in Food Systems (1994)

This volume examines the contributions of proteins to the technological and organoleptic characteristics of food. It provides a solid basis for understanding the principles of food protein functionality and offers information to help develop unique food products using proteins as novel ingredients. Properties such as solubility, viscosity, gelation
Characterization of the dog lipocalin allergen Can f 6: the role in cross‐reactivity with cat and horse (2012)

Can f 6 is a new lipocalin dog allergen that cross-reacts with lipocalins from horse and cat. Can f 6 and homologous allergens may contribute to multisensitization and symptoms in individuals allergic to mammals.
Antimicrobial equipment of poly(isoprene) applying thiol‐ene chemistry (2012)

Abstract The functionalization of anionically polymerized isoprene with cysteamine applying the thiol‐ene reaction is reported. Antimicrobial activity is implemented by quaternization of the amino functionality by either alkylation or by protonation. The resulting polymers were tested against Gram‐positive as well as Gram‐negative bacteria strains according to the Japanese Industrial Standard Z2801:2000 protocol, partly revealing excellent biocidal performance. Thermal stability up to 200°C allows extrusion processing of the functionalized poly(isoprene)s. The best performing polymer, that is, bearing butylated ammonium‐groups, was compounded with the commodity material poly(propylene). The compound bearing 5 wt % of the biocidal polymer exhibited satisfactory biocidal properties. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Refurbishment of turbogenerators for plant life extension (1988)

The need to replace major components of turbine generators depends on their expected reliability over future operating periods. Assessment of the reliability should take account of operating experience for the particular design of generator and of the condition of lead units judged from detailed inspection and NDT testing during overhaul. However, the expected reliability is only one element of the economic assessment. The decision to exchange plant will necessarily be made by the utility, taking account of such external factors as the availability of spare capacity on the system and the cost of operating replacement plant. The authors discuss various aspects of turbogenerators refurbishment concerned with the rotors and stators.
Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis (2011)

Neural stem cells (NSCs) are slowly dividing astrocytes that are intimately associated with capillary endothelial cells in the subventricular zone (SVZ) of the brain. Functionally, members of the vascular endothelial growth factor (VEGF) family can stimulate neurogenesis as well as angiogenesis, but it has been unclear whether they act directly via VEGF receptors (VEGFRs) expressed by neural cells, or indirectly via the release of growth factors from angiogenic capillaries. Here, we show that VEGFR-3, a receptor required for lymphangiogenesis, is expressed by NSCs and is directly required for neurogenesis. Vegfr3:YFP reporter mice show VEGFR-3 expression in multipotent NSCs, which are capable of self-renewal and are activated by the VEGFR-3 ligand VEGF-C in vitro. Overexpression of VEGF-C stimulates VEGFR-3-expressing NSCs and neurogenesis in the SVZ without affecting angiogenesis. Conversely, conditional deletion of Vegfr3 in neural cells, inducible deletion in subventricular astrocytes, and blocking of VEGFR-3 signaling with antibodies reduce SVZ neurogenesis. Therefore, VEGF-C/VEGFR-3 signaling acts directly on NSCs and regulates adult neurogenesis, opening potential approaches for treatment of neurodegenerative diseases.
Gds1 interacts with NuA4 to promote H4 acetylation at ribosomal protein genes (2021)

Abstract In our previously published studies, RNA polymerase II transcription initiation complexes were assembled from yeast nuclear extracts onto immobilized transcription templates and analyzed by quantitative mass spectrometry. In addition to the expected basal factors and coactivators, we discovered that the uncharacterized protein Gds1 showed activator-stimulated association with promoter DNA. Gds1 co-precipitated with the histone H4 acetyltransferase NuA4, and its levels often tracked with NuA4 in immobilized template experiments. GDS1 deletion led to reduction in H4 acetylation in vivo and other phenotypes consistent with partial loss of NuA4 activity. Genome-wide chromatin immunoprecipitation revealed that the reduction in H4 acetylation was strongest at ribosomal protein gene promoters and other genes with high NuA4 occupancy. Therefore, while Gds1 is not a stoichiometric subunit of NuA4, we propose that it interacts with and modulates NuA4 in specific promoter contexts. Gds1 has no obvious metazoan homolog, but structural predictions suggest it may be distantly related to the DEK protein.
The effects of age and dietary restriction without nutritional supplementation on whole bone structural properties in C57BL/6J mice. (1999)

While caloric restriction is a proven means to extend longevity, its effects on bone are not well understood. This study examined the effects of dietary restriction without vitamin or mineral supplementation on bone in female 60- and 120-day-old C57BL/6J mice. Baseline controls were sacrificed at 60 or 120 days, while diet-restricted animals ate approximately 72.9-78.6% of the ad libitum fed animals for thirty days. 60-day-old ad libitum animals experienced normal growth with average increases of 6.4% in bone length, 23.5% in bone mass, 9.4% in %mineralization, 36.4% in maximum strength, 59.2% in stiffness, 22.3% in cortical thickness, 12.9% in %cortical area, and 11.3% in microhardness. Growth in 120-day-old ad libitum animals followed a trend but with more modest increases. Diet-restricted mice matured very little from baseline levels in 60-day-old animals. There were no significant changes from baseline levels in the parameters indicated above, except for a 8.3% decrease in %cortical area attributable to increased resorption. 120-day-old diet-restricted animals also evidenced little deviation from baseline levels except for significant decreases in %mineralization (2.1%) and %cortical area (6.7%). The effects of diet restriction on bone properties decreased with age. Bone from 60-day-old diet-restricted mice showed diminished mechanical and compositional properties, resulting from little growth and excess resorption. Bone from 120-day-old diet-restricted mice showed little growth and some resorption. Increased resorption, localized on the endosteal surfaces, likely minimized the negative impact of structural degradation of the long bones. Resorption may have also provided minerals to compensate for nutritional deficiencies.
Optimization of solid-phase synthesis of [Ala8]-dynorphin A (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptimization of solid-phase synthesis of [Ala8]-dynorphin ANuria A. Sole and George BaranyCite this: J. Org. Chem. 1992, 57, 20, 5399–5403Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/jo00046a022https://doi.org/10.1021/jo00046a022research-articleACS PublicationsRequest reuse permissionsArticle Views1029Altmetric-Citations206LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hexagonal transverse‐coupled‐cavity VCSEL redefining the high‐speed lasers (2018)

Abstract Vertical‐cavity surface‐emitting lasers (VCSELs) have emerged as a vital approach for realizing energy‐efficient and high‐speed optical interconnects in the data centers and supercomputers. Indeed, VCSELs are the most suitable mass production lasers in terms of cost‐effectiveness and reliability. However, there are still key challenges that prevent achieving modulation speeds beyond 30s GHz. Here, we propose a novel VCSEL design of a hexagonal transverse‐coupled‐cavity adiabatically coupled through a central cavity. Following this scheme, we show a prototype demonstrating a 3‐dB roll‐off modulation bandwidth of 45 GHz, which is five times greater than a conventional VCSEL fabricated on the same epiwafer structure. This design harnesses the Vernier effect to increase the laser’s aperture and therefore is capable of maintaining single‐mode operation of the laser for high injection currents, hence extending the dynamic roll‐off point and offering increases power output. Simultaneously, extending both the laser modulation speed and output power for this heavily deployed class of lasers opens up new opportunities and fields of use ranging from data‐comm to sensing, automotive, and photonic artificial intelligence systems.
Photonic crystals: a versatile platform for optics-based biological detection (2012)

Photonic crystal surfaces that can be fabricated inexpensively over large surface areas can be designed to produce optical resonances for any desired wavelength in the optical spectrum from ultraviolet to infrared. Label-free biosensing is obtained by measuring shifts in the resonant wavelength as biomaterial deposits on the photonic crystal, while the intensified electric fields that occur due to coupling of illumination at the resonant wavelength may be used to more effectively excite fluorescence or Raman scattering. Photon emitters, such as quantum dots, fluorescent dye molecules, and Raman scatters can efficiently couple their energy to detection instruments when they are in close proximity to a photonic crystal with a resonance that matches the emission wavelength. Finally, the narrowband optical filtering capability of photonic crystals can be effectively applied for infrared absorption imaging of biological specimens at discrete wavelengths. This talk will summarize recent activities in the Nano Sensors Group at the University of Illinois in which photonic crystals are used to address a variety of problems in biological sensing.
Cover Picture: Recent Advances in the Catalytic Conversion of Cellulose (ChemCatChem 1/2011) (2011)

The cover picture shows a filmstrip illustrating the bright future of cellulosic biomass as a sustainable feedstock for producing valuable chemicals and biofuels. We are, however, still far away from cost-effective, large-scale catalytic applications and the state-of-the-art is still frequently hampered by the notorious recalcitrance of the polymeric biomolecules. In their Minireview on p. 82 ff., Van de Vyver et al. make an attempt to capture the wide range of recent developments in this area, and they speculate on possible future directions with a primary focus on the role of heterogeneous catalysis.
Cytochrome P-450: Cytochrome P-450 Reductase Interactions (1989)

(1989). Cytochrome P-450: Cytochrome P-450 Reductase Interactions. Drug Metabolism Reviews: Vol. 20, No. 2-4, pp. 519-533.
Broadcasting in Multi-Channel Wireless Infrastructure Networks Employing Directional Antenna (2010)

Multi-channel wireless networks are increasingly being employed as infrastructure networks in metro areas. In addition, nodes in these networks employ directional antennas to improve spatial throughput. In such networks, we consider the problem of finding a broadcast tree from a given root with channel assignment such that all the links in the broadcast tree can be active simultaneously without interfering with each other. We prove that finding such a tree is an NP-hard problem. Hence, we formulate the problem as an integer linear program (ILP) and develop heuristics to find the broadcast tree with channel assignment. We evaluate and compare the performances of the developed heuristics with respect to their success rate, average depth of the obtained tree, and average path length from root to a node in the network.
Mechanism of resistance of noncycling mammalian cells to 4'-(9-acridinylamino)methanesulfon-m-anisidide: comparison of uptake, metabolism, and DNA breakage in log- and plateau-phase Chinese hamster fibroblast cell cultures. (1988)

Resistance of noncycling cells to amsacrine (m-AMSA) has been widely reported and may limit the activity of this drug against solid tumors. The biochemical mechanism(s) for this resistance have been investigated using spontaneously transformed Chinese hamster fibroblasts (AA8 cells, a subline of Chinese hamster ovary-cells) in log- and plateau-phase spinner cultures. In early plateau phase most cells entered a growth-arrested state with a G1-G0 DNA content and showed a marked decrease in sensitivity to cytotoxicity induced by a 1-h exposure to m-AMSA or to its solid tumor-active analogue, CI-921. Studies with radiolabeled m-AMSA established that similar levels of drug were accumulated by log- and plateau-phase cells and that there was no significant drug metabolism in either of these cultures after 1 h. However, marked differences in sensitivity to m-AMSA-induced DNA breakage were observed using a fluorescence assay for DNA unwinding (Kanter P.M., and Schwartz, H.S., Mol. Pharmacol., 22: 145-151, 1982). Changes in sensitivity to DNA breakage occurred in parallel with changes in sensitivity to m-AMSA-induced cell killing. DNA breaks disappeared rapidly after drug removal (half-time approximately 4 min), suggesting that these lesions were probably mediated by DNA topoisomerase II. Resistance to m-AMSA may therefore be associated with changes in topoisomerase II activity in noncycling cells.
Design of Marchand balun of spiral shape using physical transformer model on silicon integrated passive device substrate (2010)

A simple and effective technique for designing integrated Marchand balun is presented in this paper. The approach uses the physical transformer model to replace the lossy coupled transmission lines in a conventional design. As a demonstration and validation of the design approach, a spiral-shaped Marchand balun using silicon integrated passive device (IPD) technology has been carried out to provide low insertion loss and high common-mode rejection ratio (CMRR) over a remarkably wide bandwidth around an operating center frequency of 2.45 GHz. Comparison among modeled, EM simulated and measured results shows good agreement.
Effect of fermented oyster extract on growth promotion in Sprague–Dawley rats (2020)

FO have high content of GABA, and induced positive effects on body length, tibial length, growth-plate length and hepatic IGF-1 synthesis in SD rats with no toxicity or alterations of hematological profile. Therefore, these results suggest that GABA-enriched FO could be considered a potential alternative treatment for growth stimulation.
Lipophilic Triphosphate Prodrugs of Various Nucleoside Analogues (2020)

The antiviral efficacy of many nucleoside analogues is strongly dependent on their intracellular activation by host cellular kinases to yield ultimately the bioactive nucleoside analogue triphosphates (NTP). The metabolic conversion of nucleoside analogues into their triphosphates often proceeds insufficiently. We developed a nucleoside triphosphate (NTP) delivery system (the Tri<i>PPP</i>ro approach), in which the γ-phosphate is covalently modified by two different biodegradable masking units, one is the acyloxybenzyl (AB) moiety and the other is the alkoxycarbonyloxybenzyl (ACB) group. Such compounds formed NTPs with high selectivity by an enzyme-triggered mechanism in human T-lymphocyte CEM cell extracts loosing first the AB moiety, followed by the ACB group. This enables the bypass of all steps of the intracellular phosphorylation. This approach was applied here to convert some modestly active or even inactive nucleoside analogues into powerful biologically active metabolites. Potent antiviral activity profiles were obtained depending on the lipophilicity of the Tri<i>PPP</i>ro-NTP prodrugs against HIV-1 and HIV-2 replication in cultures of infected wild-type CD4<sup>+</sup> CEM T-cells and more importantly in thymidine kinase-deficient CD4<sup>+</sup> T-cells (CEM/TK<sup>-</sup>). This Tri<i>PPP</i>ro strategy offers high potential for future antiviral and antitumoral chemotherapies.
Figure S7 from Functional morphology of a lobopod: case study of an onychophoran leg (2019)

<b>Morphology of the claw retractor muscle in <i>E. rowelli</i>.</b> Volume rendering based on nanoCT data from left mid-trunk leg.
A 3.6 pJ/Access 480 MHz, 128 kb On-Chip SRAM With 850 MHz Boost Mode in 90 nm CMOS With Tunable Sense Amplifiers (2009)

An extremely low energy per operation, single cycle 32 bit/word, 128 kb SRAM is fabricated in 90 nm CMOS. In the 850 MHz boost mode, total energy consumption is 8.4 pJ/access. This reduces to 3.6 pJ/access in the normal 480 MHz mode and bottoms out at a very aggressive 2.7 pJ/access in the 240 MHz low power mode. Several techniques were combined to obtain these performance numbers. Short buffered local bit lines reduce the impact of the cell read current on memory delay. Extended global bitlines are used which improves delay and energy consumption and which reduces the number of sense amplifiers in the memory to 32. Cell stability and speed issues are avoided by applying selective voltage scaling. Novel, digitally tunable sense amplifiers and a tunable timing circuit cope gracefully with the stochastic variations in the periphery.
İmam Hatip Lisesi Öğrencilerinin Özgüven Düzeyleri Hakkında Nicel Bir Analiz (2019)

Bu çalışmanın amacı, imam hatip lisesi öğrencilerinin özgüven düzeylerini bazı değişkenlere göre incelemektir. Araştırmanın çalışma grubunu Çorum il merkezinde bulunan imam hatip liselerinde öğrenim gören 276 öğrenci oluşturmaktadır. Veriler araştırmacı tarafından hazırlanan “Kişisel Bilgi Formu” ve “Öz-güven Ölçeği” kullanılarak toplanmıştır. Araştırmada Akın tarafından geliştirilen 33 maddelik Öz-güven Ölçeğinin Cronbach Alpha güvenirlik katsayısı .90 olarak bulunmuştur. Toplanan verilerin değerlendirilmesinde SPSS 16.0 paket programı kullanılmıştır. Araştırma sonucunda hem özgüven ölçeğinin geneline göre hem de alt ölçeklerden elde edilen sonuçlara göre öğrencilerin özgüven düzeylerinin yüksek olduğu tespit edilmiştir. Ayrıca, öğrencilerin özgüven düzeyleri ile aile içi iletişim, geçmiş öğretim yılı başarı durumu ve okul dışında herhangi bir etkinliğe katılma durumu arasında anlamlı bir farklılaşma bulunmuştur. Özgüven düzeyi en yüksek olan öğrenci grubunun ailesiyle iletişimlerinin de “çok iyi” olduğu görülmüştür. Geçmiş öğretim yılı başarısı yüksek olan öğrencilerin tüm ölçeklerde özgüven düzeyi de yüksek çıkmıştır. Öğrencinin başarı düzeyi arttıkça, özgüven düzeyi de artmaktadır. Sinema, konser gibi etkinliklere gitmek, çeşitli sportif faaliyetlerde yer almak, arkadaşlarıyla zaman geçirmek, yazılım kursu, işaret dili kursu, bağlama kursu, fotoğrafçılık, okçuluk, satranç ve el sanatları gibi başka etkinliklere katılmak öğrencilerin özgüvenlerini olumlu olarak etkilemektedir. Özgüven, okul dışında herhangi bir faaliyete katılmayan öğrencilerin yer aldığı grupta en düşük düzeydedir. Bununla birlikte; özgüven ile cinsiyet, sınıf düzeyi, anne-baba eğitim durumu, ailenin ekonomik durumu, ailenin öğrenciye karşı tutumu ve öğrencilerin harçlık durumu arasında ise anlamlı bir farklılığın olmadığı bulgulanmıştır.