gebhart/patrepeval huggingface dataset:
Biosafety of Brucella abortus strain RB51 for vaccination of mature bulls and pregnant heifers (1999)

Vaccination with the standard calfhood dose of SRB51 administered IM was not associated with shedding or colonization in sexually mature bulls or pregnant heifers. Also, under conditions of this study with small numbers of animals, IM vaccination with SRB51 does not appear to cause any reproductive problems when administered to sexually mature cattle.
Flip chip pin grid array (FC-PGA) packaging technology (2002)

As microelectronics moves toward greater levels of integration, functionality and performance, packaging technology complexity grows in direct proportion. With Si process evolution to finer feature sizes, microprocessor designs are achieving higher system clock speeds. As a result, the level of integration and interconnect density between processor chips and substrate has increased tremendously. This brings an array of challenges for package design, substrate technology and assembly process development. For highly integrated packaging at competitive cost, the flip chip pin grid array package (FC-PGA) is proposed as an innovative socketable solution which includes use of laser drilled blind/buried vias on PTH and SMT pins to ease routing and alleviate loop inductance. Use of an existing PGA socket infrastructure expedites OEM acceptance of the new package design in various configurations. This paper describes key features of FC-PGA and technical challenges encountered in FC-PGA design/validation and packaging process development, such as solder composition selection, SMT pin technology optimization, and resolution of via delamination and flip chip solder bump nonwetting problems. FC-PGA package design and process development efforts have demonstrated the feasibility of high density flip chip interconnect on organic substrates and high speed bus functionality with low cost, high yield, manufacturable and reliable packaging solutions, which have been utilized in Pentium/sup TM/ III microprocessors.
SAT-641 Self-Reported Psychological Stress and Glucose Variability in Type 1 Diabetes on Sensor Augmented Pump over 5 Weeks (2020)

Abstract Introduction: Patients and their families and medical providers have assumed that psychologic stress impacts glucose control in T1D (Type 1 Diabetes) though studies providing confirmatory evidence in real world settings are, to our knowledge, lacking. We hypothesized that self-reported psychologic stress worsens glucose control in T1D. Method: We studied 20 adults with T1D on continuous glucose monitor (CGM), sensor augmented insulin pump (SAP) prospectively at 2 clinical research centers. Patients reported psychological stress through stress diaries for 5 weeks on a severity scale of 1-7 using hard copy logs including time of onset and offset of stress and severity. For analytic purpose, grades 1-4 are classified as mild and grades 5-7 as severe. Results: Baseline characteristics were age 44.9±15.0 years, F/M 12/8, HbA1c 6.8 ± 0.7%, and diabetes duration of 22.9±15.9 years. We analyzed glucose variability during days of stress versus days without stress. During a 24 hour period, patients experienced less hypoglycemia during days with stress versus days without stress (p value 0.03). During the 5 week period, patients reported 23 ± 19.5 events. We analyzed the impact of self-reported stress on CGM data streams after excluding stress events associated with missing CGM data, nocturnal events (from 12 MN to 6 AM, too few events) and events for which subjects did not provide duration of stress. Thus, we analyzed 19.5 ± 17 events per patient from 6AM to 12MN. From 6 AM to 12 MN, the episodes lasted 179 ± 255 minutes with 83 % episodes being mild/moderate and 17% moderate/ severe. Number of CGM readings during daytime stress episodes were 717± 1120 compared to 8768± 1238 during non-stress periods. Impact of stress from 6 AM to 12 MN (Mid-Night) on CGM glucose was analyzed using matched paired t test. Mean glucose (160.6±41.9 vs 148.3± 28.6) and SD (53.2 ±17.7 vs 56.1±14.6) did not show a difference; however % of time spent below 70 mg/dl was less (4 ± 5) in patients during stressful periods compared to times without stress (6.3± 5.5, P value 0.02). Conclusions: To our knowledge, this is the first study attempting to analyze the impact of self-reported stress using daily stress diaries on CGM data streams in T1D patients on SAP. The study revealed significant challenges experienced by patients in reporting adequate data. Self-reported stress was not associated with hyperglycemia. However, days of self-reported stress and periods during patients reported stress were characterized by less hypoglycemia on CGM data streams.
Object-Centric Alignments (2023)

Processes tend to interact with other processes and operate on various objects of different types. These objects can influence each other creating dependencies between sub-processes. Analyzing the conformance of such complex processes challenges traditional conformance-checking approaches because they assume a single-case identifier for a process. To create a single-case identifier one has to flatten complex processes. This leads to information loss when separating the processes that interact on some objects. This paper introduces an alignment approach that operates directly on these object-centric processes. We introduce alignments that can give behavior-based insights into how closely related the event data generated by a process and the behavior specified by an object-centric Petri net are. The contributions of this paper include a definition for object-centric alignments, an algorithm to compute them, a publicly available implementation, and a qualitative and quantitative evaluation. The qualitative evaluation shows that object-centric alignments can give better insights into object-centric processes because they correctly consider inter-object dependencies. Findings from the quantitative evaluation show that the run-time grows exponentially with the number of objects, the length of the process execution, and the cost of the alignment. The evaluation results motivate future research to improve the run-time and make object-centric alignments more applicable for larger processes.
Hyperkalaemia: aetiology, epidemiology, and clinical significance (2019)

Disturbances in the potassium homeostasis are common among patients with heart failure (HF) and negatively affect clinical outcome. Patients with HF have a higher prevalence of common risk factors related to hyperkalaemia, including diabetes mellitus, hypertension, and chronic kidney disease. Furthermore, the use of renin-angiotensin-aldosterone system (RAAS) inhibitors, is an important risk factor for developing hyperkalaemia. The association between hyperkalaemia and mortality is not unequivocal, depends on the study type (trial vs. real-world setting) and is often confounded. More importantly, hyperkalaemia is an important cause of discontinuation or failure to uptitrate to guideline recommended dosages of RAAS inhibitors, which in turn may negatively impact clinical outcomes. The goal of this review is to discuss the epidemiology, aetiology, and clinical consequences of potassium disturbances in HF.
Clustering-Based Activity Detection Algorithms for Grant-Free Random Access in Cell-Free Massive MIMO (2021)

Future wireless networks need to support massive machine type communication (mMTC) where a massive number of devices accesses the network and massive MIMO is a promising enabling technology. Massive access schemes have been studied for co-located massive MIMO arrays. In this paper, we investigate the activity detection in grant-free random access for mMTC in cell-free massive MIMO networks using distributed arrays. Each active device transmits a non-orthogonal pilot sequence to the access points (APs) and the APs send the received signals to a central processing unit (CPU) for joint activity detection. The maximum likelihood device activity detection problem is formulated and algorithms for activity detection in cell-free massive MIMO are provided to solve it. The simulation results show that the macro diversity gain provided by the cell-free architecture improves the activity detection performance compared to co-located architecture when the coverage area is large.
Prevention of graft‐versus‐host disease in DLA‐haplotype mismatched dogs and hemopoietic engraftment of CD6‐depleted marrow with and without cG‐CSF treatment after transplantation (1994)

Prevention of graft-versus-host disease by depletion of CD6-positive T cells was studied in the dog. Donors were DLA-homozygous, recipients DLA-heterozygous with one DLA haplotype identical to the donor. Seven control dogs received untreated marrow and died of GvHD after full hemopoietic recovery within 28 days of transplantation. For prevention of GvHD, immunomagnetic separation of T cells with a monoclonal antibody against human CD6 that crossreacted with canine T cells was evaluated. Depletion of CD6-positive cells depleted CD4-positive cells completely, but only part of CD8-positive cells and DR-positive cells. CD6-depleted marrow exhibited strong nonspecific "natural" suppression of the generation of cytotoxic T cells in vitro. Eleven dogs received CD6-depleted marrow. Only 1 dog developed GvHD and died. Sustained engraftment was seen in 8 dogs. Hemopoietic recovery was delayed and slower after transplantation of CD6-depleted marrow than after transplantation of untreated marrow. Four of these dogs were treated with G-CSF, and this accelerated the recovery of leukocytes, but did not prevent rejection. Chimerism was mixed in 7 of 10 evaluable dogs and 1 dog recovered its own hemopoiesis 2 years after transplantation. CD6 depletion prevents GvHD across a DLA-haplotype difference, but rejection and mixed chimerism may occur. Treatment with G-CSF accelerates leukocyte recovery, but cannot prevent rejection.
Chemical Annealing of Zinc Tetraphenylporphyrin Films: Effects on Film Morphology and Organic Photovoltaic Performance (2012)

We present a chemical annealing process for organic thin films. In this process, a thin film of a molecular material, such as zinc tetraphenylporphyrin (ZnTPP), is exposed to a vapor of nitrogen-based ligand (e.g., pyrazine, pz, and triazine, tz), forming a film composed of the metal–ligand complex. Fast and quantitative formation of the complex leads to marked changes in the morphology and optical properties of the film. X-ray diffraction studies show that the chemical annealing process converts amorphous ZnTPP films to crystalline ZnTPP·ligand films, whose porphryin planes lie nearly parallel to the substrate (average deviation is 8° for the ZnTPP·pz film). Organic solar cells were prepared with ZnTPP donor and C60 acceptor layers. Devices were prepared with and without chemical annealing of the ZnTPP layer with a pyrazine ligand. The devices with chemically annealed ZnTPP donor layer show an increase in short-circuit current (JSC) and fill factor (FF) relative to analogous unannealed devices, presumably because of enhanced exciton diffusion length and improved charge conductivity. The open circuit voltages (VOC) of the chemically annealed devices are lower than their unannealed counterpart because of enhanced polaron pair recombination at the donor/acceptor heterojunction. A net improvement of 5–20% in efficiency has been achieved, after chemical annealing of ZnTPP films with pyrazine.
Measuring the pH environment of DNA delivered using nonviral vectors: Implications for lysosomal trafficking (2002)

The degradation of DNA in lysosomes represents a major obstacle to efficient nonviral gene delivery. The rational design of vectors that overcome this obstacle requires a better understanding of the lysosomal barrier to gene delivery, which in turn requires a means to investigate this intermediate step. To this end, we developed a technique to measure the pH environment of delivered DNA, from which the degree to which vectors avoided trafficking to acidic Iysosomes could be determined. The measured average pH of DNA delivered using poly-L-lysine (PLL) polyplexes was 4.5, suggesting that PLL polyplexes were trafficked to acidic lysosomes. Other vectors could avoid or buffer the pH of Iysosomes as DNA delivered using Lipofectamine Plus, polyethylenimine (PEI), linear polyethylenimine (LPEI), and two degradable poly(beta-amino ester)s (poly-1 and poly-2) had average pH values of 7.1, 5.9, 5.0, 6.7, and 6.4, respectively.
The neuroactive steroid 5beta-pregnane-3beta, 20(R)-diol alters the kinetic properties of the GABA-A receptor differently from pregnenolone-sulfate (2007)

The neuroactive steroid 5beta-pregnane-3beta, 20(R)-diol alters the kinetic properties of the GABA-A receptor differently from pregnenolone-sulfate
Supplementary Materials and Methods and Supplementary Figure Legends from Metronomic Docetaxel in PRINT Nanoparticles and EZH2 Silencing Have Synergistic Antitumor Effect in Ovarian Cancer (2023)

&lt;p&gt;PDF - 78K, Supplementary methods and legends for supplementary figures.&lt;/p&gt;
Pharmacological targeting of CDK9 in cardiac hypertrophy (2009)

Cardiac hypertrophy allows the heart to adapt to workload, but persistent or unphysiological stimulus can result in pump failure. Cardiac hypertrophy is characterized by an increase in the size of differentiated cardiac myocytes. At the molecular level, growth of cells is linked to intensive transcription and translation. Several cyclin-dependent kinases (CDKs) have been identified as principal regulators of transcription, and among these CDK9 is directly associated with cardiac hypertrophy. CDK9 phosphorylates the C-terminal domain of RNA polymerase II and thus stimulates the elongation phase of transcription. Chronic activation of CDK9 causes not only cardiac myocyte enlargement but also confers predisposition to heart failure. Due to the long interest of molecular oncologists and medicinal chemists in CDKs as potential targets of anticancer drugs, a portfolio of small-molecule inhibitors of CDK9 is available. Recent determination of CDK9's crystal structure now allows the development of selective inhibitors and their further optimization in terms of biochemical potency and selectivity. CDK9 may therefore constitute a novel target for drugs against cardiac hypertrophy.
Knowledge-Driven Analytics and Systems Impacting Human Quality of Life (2019)

The advent of artificial intelligence (AI), Internet of Things (IoT), powerful computational hardwares like graphics processing units, affordable sensing devices like smart bands, wearables, smartphones pave ways for large number of useful and intelligent applications hitherto never commonly envisaged. However, it is felt that applications, which positively influence human life and society, need distinct attention from the perspective of the researchers, application developers as well as industry. It is understood that knowledge-driven initiatives in terms of technology, application and practical deployment have strong capability to enable long term human-centric convergence of cyber-physical systems. Our endeavor is to discuss those finer details, research directions and application development aspects of analytics and systems intended for impacting human quality of life.
WIPP (Waste Isolation Pilot Plant)/SRL in situ tests: Part 2, Pictorial history of MIIT (Materials Interface Interactions Tests) and final MIIT matrices, assemblies, and sample listings (1987)

In situ testing of Savannah River Plant (SRP) waste glass is an important component in ensuring technical and public confidence in the safety and effective performance of the wasteforms. Savannah River Laboratory (SRL) is currently involved in joint programs involving field testing of SRP waste in Sweden, Belgium, and the United Kingdom. Most recently, this in situ effort has been expanded to include the first field tests to be conducted in the United States, involving burial of a variety of simulated nuclear waste systems. This new effort, called the Materials Interface Interactions Tests or MIIT, is a program jointly conducted by Sandia National Laboratory/Waste Isolation Pilot Plant (WIPP) and SRL. Over 1800 samples, supplied by the United States, France, West Germany, Belgium, Canada, Japan, and the United Kingdom, were buried approximately 650m below the earth's surface in the salt geology at WIPP, near Carlsbad, New Mexico. The MIIT program is one of the largest cooperative efforts ever undertaken in the waste management field; the data produced from these tests are designed to benefit a wide cross-section of the waste management community. An earlier document provided an overview of the WIPP MIIT program and described its place in the waste glassmore » assessment program at Savannah River. This document represents the second in this series and its objectives include: (1) providing a pictorial history of assembly and installation of wasteforms, metals, and geologic samples in WIPP; (2) providing 'finalized and completed' sample matrices for the entire 7-part MIIT program; (3) documenting final sample assemblies by the use of schematic drawings, including each sample, its orientation, and its environment; and (4) providing a complete listing of all samples and the means for managing analyses and resulting data.« less
A Personalized Bayesian Approach for Early Intervention in Gestational Weight Gain Management Toward Pregnancy Care (2021)

Pre-pregnancy body mass index and weight gain management are associated with pregnancy outcomes in expecting women. Poor gestational weight gain (GWG) management could increase the risk of adverse complications. These risks can be alleviated by lifestyle based interventions if undesired GWG trend is detected early on in the pregnancy. Current literature lacks analysis of gestational weight gain data and tracking the pregnancy over time. In this work, we collected longitudinal gestational weight gain data from women during their pregnancy and model their weight measurements to predict the end-of-pregnancy weight gain and classify it in accordance with the medically recommended guidelines. The measurement frequency of the weights is often very variable such that segments of data can be missing and the need to predict early utilising few data points complicates data modelling. We propose a Bayesian approach to forecast weight gain while effectively dealing with the limited data availability for early prediction. We validate on diverse populations from Europe and China. We show that utilising individual’s data only up to mid-way through the pregnancy, our approach produces mean absolute errors of 2.45 kgs and 2.82 kgs in forecasting end-of-pregnancy weight gain on these populations respectively, whereas the best of state-of- the-art yields 8.17 and 6.60 kgs on respective populations. The proposed method can serve as a tool to keep track of individual’s pregnancy and achieve GWG goals, thus supporting the prevention of excessive or insufficient weight gain during pregnancy.
Measurement of η production in untagged two-photon collisions at LEP (1993)

A study of twelve distinct decay channels of the ηc has been performed with the L3 detector at LEP, for an integrated luminosity of 30 pb−1. Summing all channels, 28 candidate events have been identified, with an estimated background of 11 events. The two-photon radiative width is evaluated to be Γγγ(ηc) = 8.0 ± 2.3 ± 2.4 keV.
Guidelines for Transportation, Handling, and Use of Fast Pyrolysis Bio-Oil. 1. Flammability and Toxicity (2012)

An alternative sustainable fuel, biomass-derived fast pyrolysis oil or “bio-oil”, is coming into the market in Europe. Fast pyrolysis pilot and demonstration plants for fuel applications producing tonnes of bio-oil are in operation, and commercial plants are under design. There will be increasingly larger amounts of bio-oil transportation on water and by land, leading to a need for further specifications and supporting documentation. The properties of bio-oil are different from conventional liquid fuels and, therefore, may need to overcome both technical and marketing hurdles for its acceptability in the fuels market. Multiple material safety data sheets (MSDSs) are currently being used by different producers, but there is a desire to update these as more information becomes available. In order to standardize bio-oil, quality specifications are being adopted. The first bio-oil burner fuel standard in ASTM D7544 was approved in 2010. CEN standardization has been initiated in Europe. In the EU, a new chemical regulation system REACH (Registration, Evaluation and Authorisation of Chemicals) exists. Registration under REACH has to be perfomed if bio-oil is produced or imported into the EU. In the USA and Canada, bio-oil has to be filed under the TSCA (US Toxic Substances Control Act) and DSL (Domestic Substance List), respectively. In this paper, the state of the art on standardization is discussed, and new data for the transportation guidelines is presented. The focus is on flammability and toxicity.
Circle Packings from Tilings of the Plane (2023)

We introduce a new class of fractal circle packings in the plane, generalizing the polyhedral packings defined by Kontorovich and Nakamura. The existence and uniqueness of these packings are guaranteed by infinite versions of the Koebe-Andreev-Thurston theorem. We prove structure theorems giving a complete description of the symmetry groups for these packings. And we give several examples to illustrate their number-theoretic and group-theoretic significance.
Supplementary Table 1 Legend from Circulating B-Cell Chronic Lymphocytic Leukemia Cells Display Impaired Migration to Lymph Nodes and Bone Marrow (2023)

Supplementary Table 1 Legend from Circulating B-Cell Chronic Lymphocytic Leukemia Cells Display Impaired Migration to Lymph Nodes and Bone Marrow
Suppression of Interference due to IQ Modulators in OFDM(A) Based Communication Systems (2006)

Multi-carrier modulation techniques, like OFDM, has been gaining significant interest for future wireless communication systems. In spite of all the advantages of OFDM, it has its own challenges. There are several impairments that can degrade the performance of the OFDM systems if the system and transceivers are not designed properly. IQ modulator impairements are among those that can limit the performance significantly. One of the major impacts of the IQ modulator in multiuser OFDM(A) systems (like in WiMAX) is that it introduces interference between the modulated symbols on the image carriers. In this paper, the interference effect caused by IQ modulators will be discussed. Self and multi-access interference caused by the IQ modulators will be explained for multiuser OFDM(A) systems. A joint demodulation based approach to suppress IQ modulator interference will be developed. The performance of the proposed algorithm will be obtained and the performance gains with respect to the conventional receiver will be demonstrated.
Urinary Isoprostane Levels and Age-Related Macular Degeneration (2017)

Higher levels of urinary F2-IsoPs levels were associated with AMD independent of potential confounders in Chinese adults.
Heterogeneous Integration Using Omni-Directional Interconnect Packaging (2019)

We present a new packaging building block for 3D integrated circuits: Omni Directional Interconnect (ODI). It adds a new degree of freedom in packaging that enables combining the high bandwidth benefit of standard 3D stacking with the minimal die area, thermal performance and direct power delivery of 2D packaging. ODI performance and cost benefits in high-performance computing are summarized. It is shown that by using careful assembly strategy, the required tolerances can be made the same as other 2.5/3D technologies. The fabrication results for two of the architectures are included and show good repeatability and robust assembly.