gebhart/patrepeval huggingface dataset:
Population level integration of individual effect measurements for in situ water quality assessment: a modelling approach with Gammarus fossarum (2010)

Multilevel biomarker studies are now a classical approach for the monitoring of contaminated environments. Nevertheless, even if the population constitutes a level of interest for environmental management, the characterization of in situ effects of contaminants at this level reminds difficult notably because it also integrates plastic, adaptive and neutral variability related to physical-chemical habitat or phylogeograhical constraints. For predictive approaches in chemical risk assessment, the experimental difficulty to assess impacts of toxic compounds at the population scale is currently addressed by modelling techniques. With the environmental relevant species G. fossarum, we develop this methodology in a diagnostic framework by coupling population dynamics modelling and in situ caging. Hence, we expect to enhance the ecological relevance of in situ toxicity assessment and to develop biologically integrated ecotoxicological indicators.\nOur approach proceeds in two steps. (i) Population models are developed to mechanistically link life history traits (survival, growth, reproductive activity, fertility) and the dynamics of reference native populations all along a year. For this, we use a dual approach combining laboratory and field experiments. The latter consisting in a demographic follow-up based on monthly population census (densities, size distributions) and an individual approach with field organisms caged in situ (reproduction, growth, survival). (ii) Effects of contamination, observed at the organism level through the exposure of transplanted individuals caged in contaminated stations, are projected into the dynamics of these reference populations in order to propose a diagnostic assessment of water quality at the population level.
Erratum: Kinetic inductance detectors for the OLIMPO experiment: design and pre-flight characterization (2019)

1 Changes Table 1 would have to be changed with the following. There was a mistake in the evaluation of NETCMB. (Table Presented). Table 3 would have to be changed with the following. There was a mistake in the units of "Range". (Table Presented) These changes do not affect the results and the conclusion.
Increased Risk for Dementia in Elderly Psychiatric Inpatients with Late-Onset Major Depression (2000)

Zalsman, Gil M.D.; Aizenberg, Dov M.D.; Sigler, Mayanit M.D.; Nahshony, Eitan M.D.; Karp, Leon M.D.; Weizman, Abraham M.D. Author Information
Robust Bessel-function-based method for determination of the(n,m)indices of single-walled carbon nanotubes by electron diffraction (2006)

We report a calibration-free method for the determination of chiral indices $(n,m)$ of single-walled carbon nanotubes from their electron diffraction patterns based on Bessel function analysis of the diffracted layer lines. An approach has been developed for confident identification of the orders of the Bessel functions from the intensity modulations of the diffraction layer lines, to which $(n,m)$ are correlated. In particular, we critically evaluate the effect of nanotube inclination on the validity of the method and show that the layer lines governed by high-order Bessel functions tolerate higher tilt angles than those of low-order Bessel functions and thus are favored for $(n,m)$ evaluation. The method is of particular significance in that it considerably enhances the precision of chiral indexing and makes possible the analysis of high-order Bessel functions, especially when EDPs are of relatively low pixel resolution. The technique can be extended to structural analysis of double-walled carbon nanotubes.
Effect of crystallographic dislocations on the reverse performance of 4H-SiC p-n diodes (2010)

A quantitative study was performed to investigate the impact of crystallographic dislocation defects, 21 including screw dislocation, basal plane dislocation, and threading edge dislocation, and their locations in 22 active and JTE region, on the reverse performance of 4H-SiC p-n diodes. It was found that higher leakage 23 current in diodes is associated with basal plane dislocations, while lower breakdown voltage is attributed to 24 screw dislocations. The above influence increases in severity when the dislocation is in the active region than 25 in the JTE region. Furthermore, due to the closed-core nature, the impact of threading edge dislocation on the 26 reverse performance of the p-n diodes is less severe than that of other dislocations although its density is 27 much higher.
Millisecond dynamics of BTK reveal kinome-wide conformational plasticity within the apo kinase domain (2017)

Bruton tyrosine kinase (BTK) is a key enzyme in B-cell development whose improper regulation causes severe immunodeficiency diseases. Design of selective BTK therapeutics would benefit from improved, in-silico structural modeling of the kinase's solution ensemble. However, this remains challenging due to the immense computational cost of sampling events on biological timescales. In this work, we combine multi-millisecond molecular dynamics (MD) simulations with Markov state models (MSMs) to report on the thermodynamics, kinetics, and accessible states of BTK's kinase domain. Our conformational landscape links the active state to several inactive states, connected via a structurally diverse intermediate. Our calculations predict a kinome-wide conformational plasticity, and indicate the presence of several new potentially druggable BTK states. We further find that the population of these states and the kinetics of their inter-conversion are modulated by protonation of an aspartate residue, establishing the power of MD & MSMs in predicting effects of chemical perturbations.
Effect of Interlayer on Read Write Processes in Perpendicular Recording (2008)

The interlayer in perpendicular recording affects the distance between the head and the soft underlayer (SUL, or keeper) and thus plays an important role in overall recording performance. We investigate the effect of interlayer thickness on read write processes in perpendicular recording. We show that different media designs lead to different responses during the write process. On the other hand, the effect of the interlayer thickness on the read-back process is more complicated; reducing the interlayer thickness may not necessarily lead to better performance.
A pediatrie gastric tube airway (1981)

From the Departments of Pediatrics and Anesthesiology, University of Florida College of Medicine and Department of Health Services Research. Veterans Administration Medical Center, Gainesville, FL.
An EGFR-ERK-SOX9 Signaling Cascade Links Urothelial Development and Regeneration to Cancer (2011)

Like many carcinomas, urothelial carcinoma (UroCa) is associated with chronic injury. A better understanding of this association could inform improved strategies for preventing and treating this disease. We investigated the expression, regulation, and function of the transcriptional regulator SRY-related high-mobility group box 9 (Sox9) in urothelial development, injury repair, and cancer. In mouse bladders, Sox9 levels were high during periods of prenatal urothelial development and diminished with maturation after birth. In adult urothelial cells, Sox9 was quiescent but was rapidly induced by a variety of injuries, including exposure to the carcinogen cyclophosphamide, culture with hydrogen peroxide, and osmotic stress. Activation of extracellular signal-regulated kinases 1/2 (ERK1/2) was required for Sox9 induction in urothelial injury and resulted from activation of the epidermal growth factor receptor (Egfr) by several Egfr ligands that were dramatically induced by injury. In UroCa cell lines, SOX9 expression was constitutively upregulated and could be suppressed by EGFR or ERK1/2 blockade. Gene knockdown showed a role for SOX9 in cell migration and invasion. Accordingly, SOX9 protein levels were preferentially induced in invasive human UroCa tissue samples (n = 84) compared with noninvasive cancers (n = 56) or benign adjacent urothelium (n = 49). These results identify a novel, potentially oncogenic signaling axis linking urothelial injury to UroCa. Inhibiting this axis is feasible through a variety of pharmacologic approaches and may have clinical utility.
Search for nonpointing and delayed photons in the diphoton and missing transverse momentum final state in 8 TeVppcollisions at the LHC using the ATLAS detector (2014)

A search has been performed, using the full 20.3 fb -1 data sample of 8 TeV proton-proton collisions collected in 2012 with the ATLAS detector at the LHC, for photons originating from a displaced vertex due to the decay of a neutral long-lived particle into a photon and an invisible particle. The analysis investigates the diphoton plus missing transverse momentum final state, and is therefore most sensitive to pair production of long-lived particles. The analysis technique exploits the capabilities of the ATLAS electromagnetic calorimeter to make precise measurements of the flight direction, as well as the time of flight, of photons. No excess is observed over the Standard Model predictions for background. Exclusion limits are set within the context of gauge mediated supersymmetry breaking models, with the lightest neutralino being the next-to-lightest supersymmetric particle and decaying into a photon and gravitino with a lifetime in the range from 250 ps to about 100 ns.
Molecular cloning, expression, and function of osteoclastic calcineurin Aα (2003)

This study explores the role of the calmodulin- and Ca(2+)-sensitive phosphatase calcineurin A in the control of bone resorption by mature osteoclasts. We first cloned full-length calcineurin Aalpha and Abeta cDNA from a rabbit osteoclast library. Sequence analysis revealed an approximately 95 and 86% homology between the amino acid and the nucleotide sequences, respectively, of the two isoforms. The two rabbit isoforms also showed significant homology with the mouse, rat, and human homologs. In situ RT-PCR showed evidence of high levels of expression of calcineurin Aalpha mRNA in freshly isolated rat osteoclasts. Semiquantitative analysis of staining intensity revealed no significant difference in calcineurin Aalpha expression in cells treated with vehicle vs. those treated with the calcineurin (activity) inhibitors cyclosporin A (8 x 10(-7) M) and FK506 (5 x 10(-9) and 5 x 10(-7) M). We then constructed a fusion protein comprising calcineurin Aalpha and TAT, a 12-amino acid-long arginine-rich sequence of the human immunodeficiency virus protein. Others have previously shown that the fusion of proteins to this sequence results in their receptor-less transduction into cells, including osteoclasts. Similarly, unfolding of the TAT-calcineurin Aalpha fusion protein by shocking with 8 M urea resulted in its rapid influx, within minutes, into as many as 90% of all freshly isolated rat osteoclasts, as was evident on double immunostaining with anti-calcineurin Aalpha and anti-TAT antibodies. Pit assays performed with TAT-calcineurin Aalpha-positive osteoclasts revealed a concentration-dependent (10-200 nM) attenuation of bone resorption in the absence of cell cytotoxicity or changes in cell number. TAT-hemaglutinin did not produce significant effects on bone resorption or cell number. The study suggests the following: 1) the 61-kDa protein phosphatase calcineurin Aalpha can be effectively tranduced into osteoclasts by using the TAT-based approach, and 2) the transduced protein retains its capacity to inhibit osteoclastic bone resorption.
Self‐Training Equalization (2002)

This chapter contains sections titled: Problem Definition and Fundamentals Three Algorithms for PAM Systems The Contour Algorithm for PAM Systems Self-training Equalization for Partial Response Systems Self-training Equalization for QAM Systems Examples of Applications Bibliography Appendix 15.A: On the Convergence of the Contour Algorithm
Limitations of predictingin vivobiostability of multiphase polyurethane elastomers using temperature-accelerated degradation testing (2014)

Polyurethane biostability has been the subject of intense research since the failure of polyether polyurethane pacemaker leads in the 1980s. Accelerated in vitro testing has been used to isolate degradation mechanisms and predict clinical performance of biomaterials. However, validation that in vitro methods reproduce in vivo degradation is critical to the selection of appropriate tests. High temperature has been proposed as a method to accelerate degradation. However, correlation of such data to in vivo performance is poor for polyurethanes due to the impact of temperature on microstructure. In this study, we characterize the lack of correlation between hydrolytic degradation predicted using a high temperature aging model of a polydimethylsiloxane-based polyurethane and its in vivo performance. Most notably, the predicted molecular weight and tensile property changes from the accelerated aging study did not correlate with clinical explants subjected to human biological stresses in real time through 5 years. Further, DMTA, ATR-FTIR, and SAXS experiments on samples aged for 2 weeks in PBS indicated greater phase separation in samples aged at 85°C compared to those aged at 37°C and unaged controls. These results confirm that microstructural changes occur at high temperatures that do not occur at in vivo temperatures. In addition, water absorption studies demonstrated that water saturation levels increased significantly with temperature. This study highlights that the multiphase morphology of polyurethane precludes the use of temperature accelerated biodegradation for the prediction of clinical performance and provides critical information in designing appropriate in vitro tests for this class of materials.
Novel Deoxyxylulosephosphate‐Reductoisomerase Inhibitors: Fosmidomycin Derivatives with Spacious Acyl Residues (2007)

1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr) represents an essential enzyme of the mevalonate-independent pathway of the isoprenoid biosynthesis. Using fosmidomycin as a specific inhibitor of Dxr, this enzyme was previously validated as target for the treatment of malaria and bacterial infections. The replacement of the formyl residue of fosmidomycin by spacious acyl residues yielded inhibitors active in the micromolar range. As predicted by flexible docking, evidence was obtained for the formation of a hydrogen bond between an appropriately placed carbonyl group in the acyl residue and the main-chain NH of Met214 located in the flexible catalytic loop of the enzyme.
Front-Contacted Multijunction Micro Solar Cells: Fabrication & Characterization (2018)

International audience
The 2019 surface acoustic waves roadmap (2019)

Abstract Today, surface acoustic waves (SAWs) and bulk acoustic waves are already two of the very few phononic technologies of industrial relevance and can been found in a myriad of devices employing these nanoscale earthquakes on a chip. Acoustic radio frequency filters, for instance, are integral parts of wireless devices. SAWs in particular find applications in life sciences and microfluidics for sensing and mixing of tiny amounts of liquids. In addition to this continuously growing number of applications, SAWs are ideally suited to probe and control elementary excitations in condensed matter at the limit of single quantum excitations. Even collective excitations, classical or quantum are nowadays coherently interfaced by SAWs. This wide, highly diverse, interdisciplinary and continuously expanding spectrum literally unites advanced sensing and manipulation applications. Remarkably, SAW technology is inherently multiscale and spans from single atomic or nanoscopic units up even to the millimeter scale. The aim of this Roadmap is to present a snapshot of the present state of surface acoustic wave science and technology in 2019 and provide an opinion on the challenges and opportunities that the future holds from a group of renown experts, covering the interdisciplinary key areas, ranging from fundamental quantum effects to practical applications of acoustic devices in life science.
Long term gain stability of traveling wave tubes (2002)

Long-term gain changes in traveling wave tubes (TWT) with helix slow-wave structures have been investigated. The major variable in the gain of the TWTs is the stability of the electrical resistivity of the carbon attenuator material deposited onto the helix support rods in the tube to damp oscillations and improve input-to-output isolation. The thin carbon layers used for this purpose are deposited onto the ceramic support rods by several different techniques that produce a variability in the material structure and electrical properties. These carbon layers are susceptible to physical damage due to the environment in the tube during conditioning and long-term operation. Modification of the electrical conductivity of the layer by energetic particle bombardment and chemical erosion decreases the net RF loss in the tube and causes the gain to increase with time. It was previously reported that a modification of the carbon resistivity due to lattice damage by energetic ion bombardment in the tube produced gain increases in S-band space-TWTs of up to 10 dB in the first several hundred hours of operation. This undesirable behavior was found to be caused by impurity gases in the tube from poorly cleaned parts. Proper cleaning of these parts eliminated the large gain changes during early life operation of these tubes.
Runtime mechanisms for leakage current reduction in CMOS VLSI circuits1,2 (2002)

Abstract. This paper describes two runtime mechanisms for reducing the leakage current of a CMOS circuit. In both cases, it is assumed that the system or environment produces a "sleep" signal that can be used to indicate that the circuit is in a standby mode. In the first method, the "sleep" signal is used to shift in a new set of external inputs and pre-selected internal signals into the circuit with the goal of setting the logic values of all of the internal signals so as to minimize the total leakage current in the circuit. This minimization is possible because the leakage current of a CMOS gate is a strong function of the input combination applied to its inputs. In the second method, NMOS and PMOS transistors are added to some of the gates in the circuit to increase the controllability of the internal signals of the circuit and decrease the leakage current of the gates using the "stack effect". This is, however, done carefully so that the minimum leakage is achieved subject to a delay constraint for all input-output paths in the circuit. In both cases, Boolean satisfiability is used to formulate the problems, which are subsequently solved by employing a highly efficient SAT solver. Experimental results on the circuits in the MCNC91 benchmark suite demonstrate that it is possible to reduce the leakage current by up to 70% in VLSI circuits at the expense of a very small overhead.
Locale Encoding for Scalable Multilingual Keyword Spotting Models (2023)

A Multilingual Keyword Spotting (KWS) system detects spoken keywords over multiple locales. Conventional monolingual KWS approaches do not scale well to multilingual scenarios because of high development/maintenance costs and lack of resource sharing. To overcome this limit, we propose two locale-conditioned universal models with locale feature concatenation and feature-wise linear modulation (FiLM). We compare these models with two baseline methods: locale-specific monolingual KWS, and a single universal model trained over all data. Experiments over 10 localized language datasets show that locale-conditioned models substantially improve accuracy over baseline methods across all locales in different noise conditions. FiLM performed the best, improving on average FRR by 61% (relative) compared to monolingual KWS models of similar sizes.
ChemInform Abstract: Novel Cyclic Compounds as Potent Phosphodiesterase 4 Inhibitors. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
RNN-Based Twin Channel Predictors for CSI Acquisition in UAV-Assisted 5G+ Networks (2021)

Unmanned aerial vehicles (UAVs) evolution has gained an unabated interest for the use in several applications, such as agriculture, aerial surveillance, goods delivery, disaster recovery, intelligent transportation. The main features of this technology are high coverage, strong line-of-sight (LoS) links, promising throughput, cost-effective and flexible deployment. Currently, the Third Generation Partnership Project (3GPP) is working on the specification of release-17 (R-17) new radio (NR) for non-terrestrial networks (NTN). Therefore, owing to the drastic increase of UAV technology, in this paper, we propose channel state information (CSI) compression and its recovery with the aid of machine learning (ML)-based twin channel predictors. Due to the characteristic of gaining higher LoS communication paths in UAV network, the proposed strategy can bring potential benefits such as over-the-air (OTA)-overhead reduction, minimizing mean-squared-error (MSE) of a channel and maximizing precoding gain. Simulation-based results corroborate the validity of the proposed strategy, which can reap benefits in multiple factors.
PhotoMat: A Material Generator Learned from Single Flash Photos (2023)

Authoring high-quality digital materials is key to realism in 3D rendering. Previous generative models for materials have been trained exclusively on synthetic data; such data is limited in availability and has a visual gap to real materials. We circumvent this limitation by proposing PhotoMat: the first material generator trained exclusively on real photos of material samples captured using a cell phone camera with flash. Supervision on individual material maps is not available in this setting. Instead, we train a generator for a neural material representation that is rendered with a learned relighting module to create arbitrarily lit RGB images; these are compared against real photos using a discriminator. We train PhotoMat with a new dataset of 12,000 material photos captured with handheld phone cameras under flash lighting. We demonstrate that our generated materials have better visual quality than previous material generators trained on synthetic data. Moreover, we can fit analytical material models to closely match these generated neural materials, thus allowing for further editing and use in 3D rendering.
ChemInform Abstract: Three‐Component Ag‐Catalyzed Enantioselective Vinylogous Mannich and Aza‐Diels—Alder Reactions with Alkyl‐Substituted Aldehydes. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Proximity Detection and Ranging Using a Modified Fluorescent Lamp for Security Applications (2006)

This paper describes a proximity detection system that uses a fluorescent lamp as a capacitive sensor. Because of the ubiquity of fluorescent lamps in commercial buildings, public spaces, and households, the potential applications of a capacitive sensor of this nature are numerous. These applications include people counting, real-time people tracking and detection of anomalous objects on a person for security verification. Modeling simulations and calculations of the electric fields under the lamp in the presence of a person as well as circuitry and electrode setups, which can be used to obtain a practical detection range are presented. Real-time tracking data and outputs collected from a working fluorescent lamp sensor are also presented