gebhart/patrepeval huggingface dataset:
A 1.17-pJ/b, 25-Gb/s/pin Ground-Referenced Single-Ended Serial Link for Off- and On-Package Communication Using a Process- and Temperature-Adaptive Voltage Regulator (2018)

This paper describes a short-reach serial link to connect chips mounted on the same package or on neighboring packages on a printed circuit board (PCB). The link employs an energy-efficient, single-ended ground-referenced signaling scheme. Implemented in 16-nm FinFET CMOS technology, the link operates at a data rate of 25 Gb/s/pin with 1.17-pJ/bit energy efficiency and uses a simple but robust matched-delay clock forwarding scheme that cancels most sources of jitter. The modest frequency-dependent attenuation of short-reach links is compensated using an analog equalizer in the transmitter. The receiver includes active-inductor peaking in the input amplifier to improve overall receiver frequency response. The link employs a novel power supply regulation scheme at both ends that uses a PLL ring-oscillator supply voltage as a reference to flatten circuit speed and reduce power consumption variation across PVT. The link can be calibrated once at an arbitrary voltage and temperature, then track VT variation without the need for periodic re-calibration. The link operates over a 10-mm-long on-package channel with −4 dB of attenuation with 0.77-UI eye opening at bit-error rate (BER) of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−15</sup> . A package-to-package link with 54 mm of PCB and 26 mm of on-package trace with −8.5 dB of loss at Nyquist operates with 0.42 UI of eye opening at BER of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−15</sup> . Overall link die area is 686 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{m}\,\,\times $ </tex-math></inline-formula> 565 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> with the transceiver circuitry taking up 20% of the area. The transceiver’s on-chip regulator is supplied from an off-chip 950-mV supply, while the support logic operates on a separate 850-mV supply.
Alpha‐fetoprotein‐producing Immature Mediastinal Teratoma Showing Rapid and Massive Recurrent Growth in an Adult (1992)

A case of immature mediastinal teratoma in a 43-year-old Japanese man is reported. The tumor, which was multicystic with solid zones and measured 12 x 6 x 8 cm, arose in the anterior mediastinum. The serum alpha-fetoprotein (AFP) level was elevated to 5,114 ng/ml before surgery. Histologically, the solid zones showed an admixture of irregular glands lined by columnar or cuboidal epithelium set in a spindle cell stroma, some foci of primitive neural tissue, and scattered small nests of hepatoid cells. Immunohistochemically, the hepatoid cells and epithelia lining some of the cysts showed a strongly positive reaction for AFP. Eight months after surgery, the patient died of respiratory failure caused by a rapidly growing massive recurrent tumor, which measured 40 x 24 x 13 cm, in the left thoracic cavity. However, the elevated serum AFP level had been decreasing during the course of the recurrence in response to chemotherapy. The recurrent tumor showed remarkable proliferation of loose mesenchymal tissue without primitive neural tissue. These findings suggest that immature mediastinal teratoma in adults is highly malignant, and that non-AFP-producing mesenchymal tissue played a critical role in forming the rapidly growing massive recurrent tumor in the present case.
ChemInform Abstract: Co(III)(salen)‐Catalyzed HKR of Two Stereocentered Alkoxy‐ and Azido Epoxides: A Concise Enantioselective Synthesis of (S,S)‐Reboxetine and (+)‐epi‐Cytoxazone. (2010)

Abstract Chiral cobalt complexes are efficient catalysts for the hydrolytic kinetic resolution of a variety of syn‐ and anti‐epoxides.
Effect of Alloying Elements on ZrC Particurate Dispersion in Liquid Aluminum (1990)

SiC particules are mainly used as reinforcement of metal matrix composites. However, it is impossible to incorporate SiC particles with small size (<1 μm) into molten aluminum and difficult to get a good distribution of particles. ZrC is more suitable as reinforcement than SiC, because of its thermal stability and low surface energy, so the effect of alloying elements on dispersion of ZrC particles into molten aluminum was investigated. Good wettability between ZrC particle and molten aluminum is essential for particulate incorporation. A number of reports have shown the dependence of wettability between ceramics and metals upon chemical reactions. ZrAl3 was detected in the matrix of ZrC/pure Al composite by using EPMA. The time required for incorporation of ZrC particles into molten aluminum was defined as an incorporation time. The incorporation time of ZrC was shortened by alloying Si, Ti or Bi which has strong affinity for ZrC. In this case, metallic compounds including these alloying elements were detected in the matrix. On the other hand, the incorporation time was not so influenced by adding Pb, Cu or Zn which has weak affinity for ZrC and it was prolonged by adding Zr, a constituent of ZrC particle.The incorporation time was shortened by alloying Mg, Ca and Li, although no metallic compound including these elements was detected in the matrix,The microstructure of the composite shows the particulate concentration along grain boundaries of matrix, because of its slow solidification rate. However, under the condition of rapid solidification rate by casting, the uniform particulate distribution was obtained.
Toxicity of a novel dsRNA‐based insecticide to the Colorado potato beetle in laboratory and field trials (2022)

Based on the results of this study, formulated ledprona has attributes to become a useful tool in controlling Colorado potato beetle populations that is likely to be a good fit in integrated pest management protocols. © 2022 Society of Chemical Industry.
Abstract 972: Anchoring Of Thrombomodulin On Endothelium Protects Against Mouse Lung Ischemia-reperfusion Injury (2007)

The endothelial cell (EC) transmembrane protein thrombomodulin (TM) plays a key role in controlling the intertwined pathological processes of thrombosis and inflammation both through and independen...
Open Quantum Assembly Language (2017)

This document describes a quantum assembly language (QASM) called OpenQASM that is used to implement experiments with low depth quantum circuits. OpenQASM represents universal physical circuits over the CNOT plus SU(2) basis with straight-line code that includes measurement, reset, fast feedback, and gate subroutines. The simple text language can be written by hand or by higher level tools and may be executed on the IBM Q Experience.
Selection of Glutamate-Rich Protein Long Synthetic Peptides for Vaccine Development: Antigenicity and Relationship with Clinical Protection and Immunogenicity (2001)

Antibodies against three long synthetic peptides (LSPs) derived from the glutamate-rich protein (GLURP) of Plasmodium falciparum were analyzed in three cohorts from Liberia, Ghana, and Senegal. Two overlapping LSPs, LR67 and LR68, are derived from the relatively conserved N-terminal nonrepeat region (R0), and the third, LR70, is derived from the R2 repeat region. A high prevalence of antibody responses to each LSP was observed in all three areas of endemic infection. Levels of cytophilic immunoglobulin G (IgG) antibodies against both GLURP regions were significantly correlated with protection from clinical P. falciparum malaria. Protected children from the Ghana cohort possessed predominantly IgG1 antibodies against the nonrepeat epitope and IgG3 antibodies against the repeat epitope. T-cell proliferation responses, studied in the cohort from Senegal, revealed that T-helper-cell epitopes were confined to the nonrepeat region. When used as immunogens, the LR67 and LR68 peptides elicited strong IgG responses in outbred mice and LR67 also induced antibodies in mice of different H-2 haplotypes, confirming the presence of T-helper-cell epitopes in these constructs. Mouse antipeptide antisera recognized parasite proteins as determined by immunofluorescence and immunoblotting. This indicates that synthetic peptides derived from relatively conserved epitopes of GLURP might serve as useful immunogens for vaccination against P. falciparum malaria.
A litre-scale turbulence facility for microorganism-flow interactions (2022)

&amp;lt;p&amp;gt;Bacteria and phytoplankton are abundant in aquatic environments, forming the base of the food web and mediating elemental cycling at a global scale. Understanding the interactions these microorganisms have with their turbulent fluid environments is an active area of research, largely conducted in laboratory-based flow experiments. In this work, we provide an open-source design and rigorous flow characterization for a 1L, dual oscillating grid turbulence facility, the smallest volume facility to date which produces near-isotropic, homogeneous turbulence. We optimized the tank geometry (grid-to-grid and grid-to-wall spacing), the grid geometry (for both classical and fractal grids: effective mesh size, blockage ratio, and fractal grid parameters), and the grid forcing regimes (for both coupled, antiphase and decoupled, randomized forcing: frequency range, stroke range, and randomized forcing parameters) to minimize mean flows and to produce acceptably homogeneous and isotropic turbulence within the unique constraints of a litre-scale volume. We acquired particle image velocimetry (PIV) measurements for both classical and fractal grids across a wide range of grid forcing regimes. We discuss the resulting length- and timescales relevant to microorganism-flow interactions, from the integral to the Kolmogorov scales. Finally, we discuss how the range of turbulent kinetic energy (TKE) dissipation rates achieved across the operational space of the facility mimics oceanographic turbulence in a range of in situ conditions, from the nearshore to the open ocean. This facility meets a long-standing need in the oceanography community in which feasible experimental working volumes are constrained by labor-intensive culturing requirements for large volumes of aquatic bacteria and phytoplankton.&amp;lt;/p&amp;gt;
Near-field and far-field dynamics of (Al,In)GaN laser diodes (2005)

Near- and far-field dynamics of edge-emitting (Al,In)GaN laser diodes are measured simultaneously with a 100 nm spatial and a 5 ns temporal resolution using a scanning near-field microscope. We reconstruct the phase distribution at the laser diode facet. Beam steering and near-field mode dynamics are interpreted in terms of thermal and carrier induced change of refractive index in the waveguide.
A Viscoelasticity Index for Cheese Meltability Evaluation (2000)

A device especially designed for uniaxial creep test was used in this study. Cheddar cheeses of different fat content were used. To study the linear viscoelastic response of the cheese, temperature of 40 degrees C and stress of 1119.5 Pa were chosen. Tests were carried out at cheese ages of 1, 3, 6, and 12 wk after production date. A six-element Kelvin model was used to model the creep data. Instantaneous slope of the creep curve was defined as the viscoelasticity index. The results showed that the viscoelasticity index based on viscoelastic parameters could be used for predicting cheese meltability. From the analysis of variance test, it was evident that that the viscoelasticity index can be used to distinguish the meltability of Cheddar cheeses of different ages and fat levels.
Hexagonal Boron Nitride Platelet-Based Nanocoating for Fire Protection (2019)

Because of its widespread use in furniture upholstery, buildings, and transportation, the flame retardancy of flexible polyurethane foam is a matter of great concern. In an effort to impart fire resistance in an environmentally benign manner, hexagonal boron nitride (h-BN) nanosheets were dispersed by an aqueous route and deposited as a single bilayer with polyethylenimine (PEI) on flexible polyurethane foam by using layer-by-layer assembly. Butane torch exposure and cone calorimetry show that the nanocoating performs similarly to vermiculite clay (VMT), while in situ quantitative gas phase analysis reveals that carbon monoxide emissions are lower with h-BN. The PEI/h-BN system also maintains foam flexibility and protects against weathering, preventing yellowing. These combined properties make the use of h-BN nanoplatelets an interesting alternative for the protection of polyurethane foam (and perhaps other flammable substrates).
Supplementary Data from Dolaflexin: A Novel Antibody–Drug Conjugate Platform Featuring High Drug Loading and a Controlled Bystander Effect (2023)

&lt;p&gt;Supplementary methods, data and Figures&lt;/p&gt;
Modeling and Analysis of Touch on the Flexible Ultra-Thin Touch Panel by Using the Finite Element Method (2016)

The work employs the finite element method to model the finger touch on the flexible ultra-thin touch panel for analyzing the touch signal. The touch signal generates the ghost points when the fingers multi-touch on the flexible ultra-thin touch panel. The simulation of minimizing the top layer (over cover) thickness based on the model is conducted in order to eliminate the ghost points. The simulation results show the over cover thickness should be larger than 107 μm to eliminate the ghost points. Further, we propose the method to solve the ghost points and minimize the over cover thickness. The simulation results conducted in this proposed method show that the over cover thickness can be reduced further to 65 μm.
Trace Level Detection and Quantification of Crystalline Silica in an Amorphous Silica Matrix with Natural Abundance 29Si NMR (2020)

A protocol for the detection of trace amounts of quartz in amorphous silica gels by NMR spectroscopy was developed and tested on commercially available samples. Using natural abundance <sup>29</sup>Si MAS NMR spectroscopy with CPMG acquisition and standard addition of crystalline quartz, quantitative detection of quartz concentrations down to 0.1% wt. was achieved. CPMG permitted to suppress the amorphous silica-derived signal, benefitting from the extremely long <i>T</i><sub>2</sub> relaxation time of quartz in <sup>29</sup>Si and hence dramatically increasing the sensitivity. Dedicated post-processing exploiting the known CPMG spikelet frequencies allowed to probe the near-absence of quartz in commercial, 100% silica samples, enabling assessment of conformity of unknown samples to EU legislation (REACH).
Teaching the principles of biotechnology transfer: A service-learning approach (2003)

As concerns about genetically modified crops, biotechnology and technology transfer have come to the forefront of media coverage and governmental policies, such issues clearly have implications on the life of every citizen around the world. To combat uncertainties about biotechnology and technology transfer with firsthand knowledge of these subjects, a biotechnology service-learning course was designed. This class examines interdisciplinary issues regarding the transfer of biotechnology and agricultural and medical technologies through the utilization of didactic and service-learning activities. The course provides a forum to discuss global issues with respect to biotechnology transfer, which are becoming more commonly addressed by scientists, social scientists and politicians in our society. The objectives of this undergraduate course are (1) to broaden the perspective of students on global issues related to technology transfer from developed countries to developing countries, (2) to examine the efficacy of technology transfer to developing countries through case studies, (3) to critically evaluate current opinions regarding the benefits and costs of technology transfer to both developed and developing countries, and (4) to become aware of and involved with community organizations addressing the needs for and methodologies involved in technology transfer to developing countries.
Spark-Based Large-Scale Matrix Inversion for Big Data Processing (2016)

Matrix inversion is a fundamental operation for solving linear equations for many computational applications, especially for various emerging big data applications. However, it is a challenging task to invert large-scale matrices of extremely high order (several thousands or millions), which are common in most Web-scale systems, such as social networks and recommendation systems. In this paper, we present an lower upper decomposition-based block-recursive algorithm for large-scale matrix inversion. We present its well-designed implementation with optimized data structure, reduction of space complexity, and effective matrix multiplication on the Spark parallel computing platform. The experimental evaluation results show that the proposed algorithm is efficient to invert large-scale matrices on a cluster composed of commodity servers and is scalable for inverting even larger matrices. The proposed algorithm and implementation will become a solid foundation for building a high-performance linear algebra library on Spark for big data processing and applications.
Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine–driven inflammation and fibrosis (2016)

Thymic stromal lymphopoietin (TSLP), interleukin-25 (IL-25), and IL-33 are important initiators of type 2-associated mucosal inflammation and immunity. However, their role in the maintenance of progressive type 2 inflammation and fibrosis is much less clear. Using chronic models of helminth infection and allergic lung inflammation, we show that collective disruption of TSLP, IL-25, and IL-33 signaling suppresses chronic and progressive type 2 cytokine-driven inflammation and fibrosis. In a schistosome lung granuloma model or during chronic Schistosoma mansoni infection in the liver, individual ablation of TSLP, IL-25, or IL-33/ST2 had no impact on the development of IL-4/IL-13-dependent inflammation or fibrosis. However, significant reductions in granuloma-associated eosinophils, hepatic fibrosis, and IL-13-producing type 2 innate lymphoid cells (ILC2s) were observed when signaling of all three mediators was simultaneously disrupted. Combined blockade through monoclonal antibody (mAb) treatment also reduced IL-5 and IL-13 expression during primary and secondary granuloma formation in the lungs. In a model of chronic house dust mite-induced allergic lung inflammation, combined mAb treatment did not decrease established inflammation or fibrosis. TSLP/IL-33 double-knockout mice treated with anti-IL-25 mAb during priming, however, displayed decreased inflammation, mucus production, and lung remodeling in the chronic phase. Together, these studies reveal partially redundant roles for TSLP, IL-25, and IL-33 in the maintenance of type 2 pathology and suggest that in some settings, early combined targeting of these mediators is necessary to ameliorate progressive type 2-driven disease.
ChemInform Abstract: Palladium‐Catalyzed Amination of Aryl Iodides. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Topological disorder in peripheral vision (1994)

One of the most striking properties of the mammalian visual system is that it is only the central part of the visual field, the fovea, where vision is most acute. The superiority of the fovea is particularly evident in tasks requiring accurate spatial localization. It is currently thought that peripheral spatial uncertainty is a simple consequence of the decreased sampling grain of the peripheral field. We show that the topological fidelity of the afferent projection declines with eccentricity away from the fovea and that it is this rather than the sampling grain that underlies the poorer performance of the periphery in tasks involving spatial localization. The combination of normal sampling and a disordered topology results in the periphery having good sensitivity for detection but poor sensitivity for object recognition.
In-Vivo Indentation Testing of Sheep Spinal Cord with Meninges (2015)

In spinal cord stimulation (SCS) therapy neuromodulation leads are interacting with human dura during and after their implantations. Knowledge of the mechanical properties of spinal cord with meninges is essential for lead design, development, and optimization. In this study, an in-vivo indentation test method was developed to assess the equivalent Young’s Modulus of sheep spinal cord with meninges. Histological analysis of the spinal cord with meninges was conducted. In-vivo equivalent Young’s Modulus was compared with published Young’s Modulus of cadaver dura and spinal cord respectively. The equivalent modulus has a mean of 0.022 MPa and a standard deviation of 0.014 MPa. Compared to the elastic modulus of spinal cord and the elastic modulus of dura mater, the equivalent elastic modulus of spinal cord with meninges is much smaller.
Interfacial effects due to tunneling to insulator gap states in amorphous carbon on silicon metal-insulator-semiconductor structures (1984)

ac conductance and capacitance measurements over the range 10 Hz to 10 MHz for amorphous carbon on silicon metal-insulator-semiconductor structures are reported. Data can be interpreted as being due to tunneling of electrons into gap states located in the dielectric. Interface state densities as low as 1.3×1010 eV cm2 are found.
STUDY OF ANTIBODIES TO HISTONES AND HISTONE SYNTHETIC PEPTIDES IN PAUCIARTICULAR JUVENILE CHRONIC ARTHRITIS (1993)

The objective of this study was to determine the prevalence of histone antibodies in early onset pauciarticular juvenile chronic arthritis (JCA), and to assess any association with disease activity in terms of arthritis or uveitis. Forty-four children with early onset pauciarticular JCA have been assessed prospectively using clinical and laboratory parameters. Sera were collected from these patients during clinical follow-up. Some of them had serial measurements during the period of study. Patient sera were analysed for histone antibodies by ELISA. A further study using 30 synthetic peptides of calf thymus core histones was performed by ELISA. Seventy-five per cent of children have IgM antibodies to histone, usually to more than one type. The highest values were anti H3 and H4 antibodies. There was no correlation between the level of anti-histone antibodies and anterior uveitis. There were increased levels of IgG antibodies to histone peptides, in particular the N- and C-terminal peptides of H3 in 70.5% of children. Antibodies to H3 peptides tend to be in patients with chronic anterior uveitis (P = 0.04).
ChemInform Abstract: Sequential Diels‐Alder Reactions on a 1,3,7,9‐Tetraene: An Efficient and Stereoselective Route to the Perhydrophenanthrene Skeleton. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.