gebhart/patrepeval huggingface dataset:
Widely varying photophysical properties of ligand-nitrated bis(.mu.-chloro)tetrakis(2-phenylpyridinato)diiridium(III) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTWidely varying photophysical properties of ligand-nitrated bis(.mu.-chloro)tetrakis(2-phenylpyridinato)diiridium(III)Gregory A. Carlson, Peter I. Djurovich, and Richard J. WattsCite this: Inorg. Chem. 1993, 32, 21, 4483–4484Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://pubs.acs.org/doi/10.1021/ic00073a001https://doi.org/10.1021/ic00073a001research-articleACS PublicationsRequest reuse permissionsArticle Views364Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ab initio calculation of the properties and the geometry of the lowest triplet state of pyrazine (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAb initio calculation of the properties and the geometry of the lowest triplet state of pyrazineJames C. Ellenbogen, David Feller, and Ernest R. DavidsonCite this: J. Phys. Chem. 1982, 86, 9, 1583–1588Publication Date (Print):April 1, 1982Publication History Published online1 May 2002Published inissue 1 April 1982https://doi.org/10.1021/j100206a022RIGHTS & PERMISSIONSArticle Views53Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (823 KB) Get e-Alerts
Mode of origin differentially influences the fitness of parthenogenetic freshwater snails (2005)

How parthenogenetic lineages arise from sexual ancestors may strongly influence their persistence over evolutionary time. Hybrid parthenogens often have elevated heterozygosity and ploidy, thus making it difficult to disentangle the influence of reproductive mode, hybridity and ploidy on their relative fitness. By comparing the relative fitness of both hybrid and non-hybrid parthenogens to their sexual ancestors, further insight may be gained into how these three factors influence the maintenance of sexual and parthenogenetic reproduction. In the present study, hybrid and non-hybrid parthenogenetic and sexual snails (Campeloma sp.) were compared for the following characteristics: female size-fecundity curves, offspring size, survivorship, and growth. Compared to nearby sexual populations, triploid hybrid parthenogens from the Florida Gulf coast have similar fecundity and offspring size, five-times higher survivorship, and 60% higher growth. Relative to nearby sexual populations, non-hybrid parthenogenetic C. limum from the Atlantic coast have significantly higher fecundity, smaller offspring size, similar survivorship and slightly lower growth. Given the considerable fitness advantages of parthenogens, especially hybrid parthenogens, it is enigmatic as to why these parthenogens occupy marginal natural habitats.
Designing functional aromatic multisulfonyl chloride initiators for complex organic synthesis by living radical polymerization (2000)

The similarities and differences between sulfonyl chloride and alkyl halide initiators for metal-catalyzed living radical polymerizations are discussed. The differences in the rates of formation, reactivities, and reactions of primary radicals derived from sulfonyl halides and alkyl halides demonstrated the design principles for monosulfonyl and multisulfonyl chlorides that provided quantitative initiation and higher rates of initiation than of propagation. Multifunctional initiators with two, three, four, six, and eight sulfonyl chloride groups that produced perfect star polymers in 95% conversions were designed and synthesized on the basis of these principles. © 2000 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 38: 4776–4791, 2000
Regelung von rotierenden Blutpumpen zur Linksherzunterstützung (2010)

Zusammenfassung Es wird ein physiologischer Regelalgorithmus für ein kontinuierlich förderndes Herzunterstützungssystem vorgestellt. Die Regelung erfolgt auf der Basis der vom System INCOR gelieferten Messwerte des Differenzdruckes. Dabei wird die Pulsatilität des Differenzdruckes auf einen Sollwert geregelt. Die Vorgabe des Sollwertes erfolgt automatisch durch Identifikation und Einstellung eines der klinischen Indikation entsprechenden Arbeitspunktes.
Supplementary Data S1a and S1b from Optimizing Precision Medicine for Breast Cancer Brain Metastases with Functional Drug Response Assessment (2023)

&lt;p&gt;S1a. Breast cancer brain metastases cohort (Group A) selection S1b. Clinical characteristics of breast cancer brain metastases cohort (Group A)&lt;/p&gt;
Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP (2016)

The protein methyltransferase (PMT) SETDB1 is a strong candidate oncogene in melanoma and lung carcinomas. SETDB1 methylates lysine 9 of histone 3 (H3K9), utilizing S-adenosylmethionine (SAM) as the methyl donor and its catalytic activity, has been reported to be regulated by a partner protein ATF7IP. Here, we examine the contribution of ATF7IP to the in vitro activity and substrate specificity of SETDB1. SETDB1 and ATF7IP were co-expressed and 1:1 stoichiometric complexes were purified for comparison against SETDB1 enzyme alone. We employed both radiometric flashplate-based and SAMDI mass spectrometry assays to follow methylation on histone H3 15-mer peptides, where lysine 9 was either unmodified, monomethylated, or dimethylated. Results show that SETDB1 and the SETDB1:ATF7IP complex efficiently catalyze both monomethylation and dimethylation of H3K9 peptide substrates. The activity of the binary complex was 4-fold lower than SETDB1 alone. This difference was due to a decrease in the value of kcat as the substrate KM values were comparable between SETDB1 and the SETDB1:ATF7IP complex. H3K9 methylation by SETDB1 occurred in a distributive manner, and this too was unaffected by the presence of ATF7IP. This finding is important as H3K9 can be methylated by HMTs other than SETDB1 and a distributive mechanism would allow for interplay between multiple HMTs on H3K9. Our results indicate that ATF7IP does not directly modulate SETDB1 catalytic activity, suggesting alternate roles, such as affecting cellular localization or mediating interaction with additional binding partners.
High‐Speed Optical Communications Using Advanced Modulation Formats (2016)

Conventional optical transmission systems use simple modulation techniques, while radio‐wave wireless systems rely on advanced modulation formats to increase spectral efficiency. However, state‐of‐the‐art optical modulation techniques can provide precise and high‐speed control of lightwave for advanced modulation formats, so the difference in modulation formats becomes small enough to use optical modulation techniques for radio‐wave communications. This article reviews high‐speed optical communication systems and focusing on optical modulation and demodulation technologies. Recently developed vector modulation techniques, which can control amplitude, phase, and frequency comprehensively, are discussed. In addition, high‐performance digital signal processing and narrow‐linewidth lasers, enabling recovery of optical phase under fluctuation of lasers or fibers, are also presented.
The sharing architecture (2014)

Businesses and Academics are increasingly turning to Infrastructure as a Service (IaaS) Clouds such as Amazon's Elastic Compute Cloud (EC2) to fulfill their computing needs. Unfortunately, current IaaS systems provide a severely restricted pallet of rentable computing options which do not optimally fit the workloads that they are executing. We address this challenge by proposing and evaluating a manycore architecture, called the Sharing Architecture, specifically optimized for IaaS systems by being reconfigurable on a sub-core basis. The Sharing Architecture enables better matching of workload to micro-architecture resources by replacing static cores with Virtual Cores which can be dynamically reconfigured to have different numbers of ALUs and amount of Cache. This reconfigurability enables many of the same benefits of heterogeneous multicores, but in a homogeneous fabric, and enables the reuse and resale of resources on a per ALU or per KB of cache basis. The Sharing Architecture leverages Distributed ILP techniques, but is designed in a way to be independent of recompilation. In addition, we introduce an economic model which is enabled by the Sharing Architecture and show how different users who have varying needs can be better served by such a flexible architecture. We evaluate the Sharing Architecture across a benchmark suite of Apache, SPECint, and parts of PARSEC, and find that it can achieve up to a 5x more economically efficient market when compared to static architecture multicores. We implemented the Sharing Architecture in Verilog and present area overhead results.
Anionic polymerization and polyhomologation: an ideal combination to synthesize polyethylene-based block copolymers (2013)

A novel one-pot methodology combining anionic polymerization and polyhomologation, through a "bridge" molecule (BF3OEt2), was developed for the synthesis of polyethylene (PE)-based block copolymers. The anionically synthesized macroanion reacts with the "bridge" molecule to afford a 3-arm star (trimacromolecular borane) which serves as an initiator for the polyhomologation.
Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy (2021)

These data show a safe, effective intratumoral therapy that can enhance antigen presentation and recruit CD8 T cells, which are required for the antitumor efficacy. We identify a Tavo treatment-related gene signature associated with improved outcomes and conversion of nonresponsive tumors, potentially even beyond TNBC.
Exploiting HBM on FPGAs for Data Processing (2022)

Field Programmable Gate Arrays (FPGAs) are increasingly being used in data centers and the cloud due to their potential to accelerate certain workloads as well as for their architectural flexibility, since they can be used as accelerators, smart-NICs, or stand-alone processors. To meet the challenges posed by these new use cases, FPGAs are quickly evolving in terms of their capabilities and organization. The utilization of High Bandwidth Memory (HBM) in FPGA devices is one recent example of such a trend. In this article, we study the potential of FPGAs equipped with HBM from a data analytics perspective. We consider three workloads common in analytics-oriented databases and implement them on an FPGA showing in which cases they benefit from HBM: range selection, hash join, and stochastic gradient descent for linear model training. We integrate our designs into a columnar database (MonetDB) and show the trade-offs arising from the integration related to data movement and partitioning. We consider two possible configurations of the HBM, using a single and a dual clock version design. With the right design, FPGA+HBM-based solutions are able to surpass the highest performance provided by either a two-socket POWER9 1 system or a 14-core Xeon 2 E5 by up to 5.9× (range selection), 18.3× (hash join), and 6.1× (SGD).
Organometallic Bioprobes for Cellular Imaging (2014)

The aim of this chapter is to illustrate the unique contribution made by transition organometallic complexes in the field of cellular imaging, emphasizing their specificity, and indeed their superiority, compared with organic and inorganic tracers. Historically, the word “bioprobes” stands for functional molecules or devices that provide information about biological systems. However, bioprobes dedicated to cellular imaging require additional attributes, such as stability toward enzymes and preservation of their photophysical or spectroscopic features in cells when subjected to UV-vis or infrared radiation. Since eukaryotic cells are small and complex, it is very difficult to elucidate their structure, establish their molecular composition, and ultimately understand the role and function of their specific components. For these reasons, techniques that allow light to penetrate deep within a cell provide invaluable information regarding cell biology. The goal is not only to describe the biology at a single-component level but also to understand biological processes, mechanisms, and principles. In this chapter, we present an overview of d6, d8, and d10 metal-based organometallic compounds suitable for cellular imaging. In particular, luminescent complexes containing Re(I), Ir(III), Rh(III), Pt(II), and Au(I) and metal carbonyl complexes of Re, Os, and Mn that can be detected, thanks to vibrational techniques (infrared and Raman), will be discussed.
Maximum Likelihood-based Gridless DoA Estimation Using Structured Covariance Matrix Recovery and SBL with Grid Refinement (2022)

We consider the parametric data model employed in applications such as line spectral estimation and direction-of-arrival estimation. We focus on the stochastic maximum likelihood estimation (MLE) framework and offer approaches to estimate the parameter of interest in a gridless manner, overcoming the model complexities of the past. This progress is enabled by the modern trend of reparameterization of the objective and exploiting the sparse Bayesian learning (SBL) approach. The latter is shown to be a correlation-aware method, and for the underlying problem it is identified as a grid-based technique for recovering a structured covariance matrix of the measurements. For the case when the structured matrix is expressible as a sampled Toeplitz matrix, such as when measurements are sampled in time or space at regular intervals, additional constraints and reparameterization of the SBL objective leads to the proposed structured matrix recovery technique based on MLE. The proposed optimization problem is non-convex, and we propose a majorization-minimization based iterative procedure to estimate the structured matrix; each iteration solves a semidefinite program. We recover the parameter of interest in a gridless manner by appealing to the Caratheodory-Fejer result on decomposition of PSD Toeplitz matrices. For the general case of irregularly spaced time or spatial samples, we propose an iterative SBL procedure that refines grid points to increase resolution near potential source locations, while maintaining a low per iteration complexity. We provide numerical results to evaluate and compare the performance of the proposed techniques with other gridless techniques, and the CRB. The proposed correlation-aware approach is more robust to environmental/system effects such as low number of snapshots, correlated sources, small separation between source locations and improves sources identifiability.
Supplementary Figure 3 from Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors (2023)

Supplementary Figure 3 from Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors
Supplemental Figures 1-4; Supplemental Tables 2,4,5 from <i>HEXIM1</i> as a Robust Pharmacodynamic Marker for Monitoring Target Engagement of BET Family Bromodomain Inhibitors in Tumors and Surrogate Tissues (2023)

&lt;p&gt;Supplemental Figure 1. Chemical structure and biochemical potency of BET inhibitors used in this study. Supplemental Figure 2. Rapid reversal of PD marker responses upon BET inhibitor washout in OPM-2 cells. Supplemental Figure 3. In vivo antitumor efficacies of ABBV-075 in the OPM-2 model at the 0.25 mg/kg, qdx21 and 1 mg/kg, qdx21 dose levels. Supplemental Figure 4. Identification of potential PD markers in skin. Supplemental Table 2. Common pathways regulated by MS417 in NCI-H1299 and MiaPaCa-2 cells Supplemental Table 4.Correlation of EC50s of MS417 and ABBV-075 in regulating PD makers vs. their anti-proliferative EC50s in OPM-2 cells. Supplemental Table 5. Identification of potential PD markers in whole blood.&lt;/p&gt;
Condition monitoring and diagnostics [Editorial] (2013)

This special issue of the IEEE Transactions on Dielectrics and Electrical Insulation (TDEI) is devoted to Condition Monitoring and Diagnostics (CMD) of high voltage insulation systems. Our intension was to pinpoint actual trends in this area of research and engineering. Especially the diagnostics of insulation systems of power equipment becomes particularly important, driven by multi-stress operational conditions and the strive for higher transmission capacity. Also the increasing requirements with respect to safety and reliability in electric power and industrial networks as well as their environmental compatibility set new and special demands.
Supplementary Table S1 from A Phase II Trial of Dovitinib in BCG-Unresponsive Urothelial Carcinoma with <i>FGFR3</i> Mutations or Overexpression: Hoosier Cancer Research Network Trial HCRN 12-157 (2023)

&lt;p&gt;Supplementary Table S1: All-Grade Toxicity&lt;/p&gt;
Immunoconjugates and new molecular targets in hairy cell leukemia. (2012)

Hairy cell leukemia (HCL) is a B-cell malignancy that in its classic form is exquisitely sensitive to single-agent purine analog therapy, but that is associated in many patients with late relapse and eventual purine analog resistance. Minimal residual disease, which is present in most patients achieving complete remission with purine analogs, retains Ags that are ideal for targeted therapy. Rituximab, which targets CD20, is active as a single agent, particularly if combined with purine analogs. Recombinant immunotoxins targeting either CD25 or CD22 and containing truncated Pseudomonas exotoxin have achieved major responses in relapsed/refractory HCL. Moxetumomab pasudotox in phase 1 testing achieved responses in 86% of such patients (complete in 46%) without dose limiting toxicity and often without MRD. Soluble CD22 has been used for improved detection and monitoring of HCL, particularly the poor-prognosis variant that lacks CD25. Ig rearrangements unique for each HCL patient have been cloned, sequenced, and followed by real-time quantitative PCR using sequence-specific reagents. Analysis of these rearrangements has identified an unmutated IGVH4-34-expressing poor-prognosis variant with immunophenotypic characteristics of either classic or variant HCL. The BRAF V600E mutation, reported in 50% of melanomas, is present in > 85% of HCL cases that are both classic and express rearrangements other than IGVH4-34, making HCL a potential target for specific inhibitors of BRAF V600E. Additional targets are being defined in both classic and variant HCL, which should improve both detection and therapy.
ChemInform Abstract: N,N′‐Bis(2,2,2‐trifluoroethyl)‐N,N′‐ethylenetartramide: An Improved Chiral Auxiliary for the Asymmetric Allylboration Reaction. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Metalorganic chemical vapor deposition route to epitaxial neodymium gallate thin films (1992)

Phase-pure epitaxial thin films of the YBa2Cu3O7−δ lattice-matched, low dielectric loss perovskite insulator NdGaO3 have been grown on (110) LaAlO3 substrates by a metalorganic chemical vapor deposition (MOCVD)/post-annealing process. Amorphous Nd-Ga-O films are first prepared by MOCVD using the volatile metalorganic β-diketonate precursors Nd(dpm)3 and Ga(dpm)3 (dpm=dipivaloylmethanate). Subsequent postannealing affords phase pure, highly oriented [(001) and/or (110) orientations perpendicular to the substrate surface] and epitaxial NdGaO3 films as assessed by x-ray diffraction θ-2θ, ω, and φ scans. Cross-sectional high-resolution electron microscopic images show that the epitaxial growth occurs with atomically abrupt film-substrate interfaces and with coexisting NdGaO3 (001) and (110) orientation domains.
Multi-criteria aggregation for adaptive multifunction Radar Resource Management performances evaluation (2017)

Multifunction radars (MFR) have to achieve their capability requirements in an increasingly complex environment, populated with diverse and hostile targets (e.g. low RCS, low speed targets in clutter or high speed, ballistic targets) in saturating scenarios (due to e.g. RF interference or threats). These radar systems are increasingly exploiting active electronically scanned array (AESA) technology to dynamically interleaved functions. However, the increasing complexity and adaptive nature of MFR radar makes it very difficult to specify their performance in a way which can both deliver the required capability and which can be verified in a cost-effective manner. Addressing the challenges in this area will benefit via better understood requirements which can be more easily interpreted. After definition of FoM (Figures of Merit) for phased array radar operation and performance, we have computed them on benchmark test scenarios of varying complexity. We describe a new methodology to aggregate these metrics to provide a global notation of MFR radar performances.