gebhart/patrepeval huggingface dataset:
Dendrite Growth Suppression by Zn2+‐Integrated Nafion Ionomer Membranes: Beyond Porous Separators toward Aqueous Zn/V2O5 Batteries with Extended Cycle Life (2019)

The dendritic/irregular growth of zinc deposits in the anode surface is often considered as a major intricacy limiting the lifespan of aqueous zinc‐ion batteries. The effect of separators on the evolution of the surface morphology of the anode/cathode is never thoroughly studied. Herein, for the first time, the efficacy of the Zn 2+ ‐integrated Nafion ionomer membrane is demonstrated as a separator to effectively suppress the growth of irregular zinc deposits in the metallic anode of an aqueous Zn/V 2 O 5 battery. The Zn 2+ ‐ions coordinated with the moieties in Nafion result in a high transference number of the Zn 2+ cation, all the while facilitating a high ionic conductivity. The Zn 2+ ‐integrated Nafion membrane enables the Zn/V 2 O 5 cell to deliver a high specific capacity of 510 mAh g −1 at a current of 0.25 A g −1 , which is close to the theoretical capacity of anhydrous V 2 O 5 (589 mAh g −1 ). Moreover, the same cell exhibits an excellent cycling stability of 88% retention of the initial capacity even after 1800 charge–discharge cycles, superior to that of the Zn/V 2 O 5 cells comprising conventional porous separators.
ChemInform Abstract: Biomimetic Ion Transport: A Functional Model of a Unimolecular Ion Channel. (1989)

Abstract A mixture of the regio‐ and stereoisomers of the macrocycle (VII) and its analogues obtained from (V) and (VIII) (instead of (IV)) is used to form a unimolecular ion channel.
Antioxidant Activities of Plant Extracts (Ammannia multiflora, Ammannia coccinea, and Salix gracilistyla) Activate the Nrf2/HO-1 Signaling Pathway (2023)

To identify potent plant extracts with strong antioxidant activity, we evaluated the free radical scavenging activity of 184 plant extracts obtained from the Freshwater Bioresources Culture Collection (FBCC) of Nakdonggang National Institute of Biological Resources (Republic of Korea), as various plant extracts have been used therapeutically to prevent chronic diseases associated with oxidative stress. From them, three plant extracts (FBCC-EP858 from Ammannia multiflora, FBCC-EP920 from Ammannia coccinea, and FBCC-EP1014 from Salix gracilistyla) were selected based on their abilities to scavenge the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical with more than 80% efficiency. We found that these extracts had in vitro half maximal inhibitory concentration (IC50) values ranging from 11.89 to 14.26 μg/mL and strong total antioxidant activity (corresponding to approximately 0.18, 0.22, and 0.23 mM Trolox, respectively). We also studied the effect of these extracts on RAW 264.7 macrophages and found that FBCC-EP920 significantly downregulated relative cell viability at a concentration of 100 μg/mL. However, the other two extracts, FBCC-EP858 and FBCC-EP1014, did not affect cell viability at the same concentration. Additionally, all three extracts inhibited hydrogen peroxide (H2O2)-induced reactive oxygen species (ROS) production and depolarization of mitochondrial membrane potential in RAW 264.7 macrophages. An additional experiment in zebrafish larvae showed that the three extracts reduced 2′,7′-dichlorodihydrofluorescein diacetate (DCFDA) fluorescent intensity induced by H2O2. The extracts also upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expression, and an HO-1 inhibitor, zinc protoporphyrin (ZnPP), attenuated the extract-induced antioxidant activity both in vivo and in vitro. Taken together, these findings suggest that the extracts from A. multiflora, A. coccinea, and S. gracilistyla have potential free radical scavenging and antioxidant capacities both in vivo and in vitro by activating the Nrf2/HO-1 signaling pathway. These results could be useful for the prevention and treatment of various oxidative stress-mediated human diseases.
Dynamic Techniques for Very Complex Database Queries. (1993)

In the title compound, trans-[PtCl2(C15H15ClFN5)2], the Pt(II) atom, located on an inversion centre, is coordinated by the purine N atoms of the 2-chloro-6-[(3-fluoro-benz-yl)amino]-9-isopropyl-9H-purine ligands and two Cl atoms in a slightly distorted trans-square-planar coordination geometry [N-Pt-Cl angles = 89.91 (5) and 90.09 (5)°]. Weak intra-molecular N-H⋯Cl contacts occur. In the crystal, C-H⋯Cl and C-H⋯F contacts, as well as weak π-π stacking inter-actions [centroid-centroid distances = 3.5000 (11) and 3.6495 (12) Å] connect the mol-ecules into a three-dimensional architecture.
Tutorial on fuzzy control (1993)

Fuzzy logic can be summed up as a technique for handling 'lexically imprecise propositions' and in particular answering queries through propagation of 'elastic constraints'. In simpler terms fuzzy logic might be considered as a providing a framework for handling rules (for control or decision making) which have been expressed in an imprecise form. Rule based systems are those which use expertise expressed as a set of rules. Rule based systems need not use fuzzy logic and indeed many have been built which use other forms of knowledge representation. However in control applications, rule based approaches have often needed to work with fuzzy representation because of the way the control expertise has been expressed. One of the key concepts of fuzzy logic is that of a linguistic variable. Take for example temperature which would be a linguistic variable in the control of a heater. It can take on linguistic value such as high, low and quite low. Such linguistic variables are embedded in the rules of a fuzzy controller and allow human control expertise to be represented. The paper considers why fuzzy control can be a technical solution, what the structure of a fuzzy controller is and what applications are being tackled. It concludes by considering where new developments will help in the application of fuzzy control.<
 >
The Molecular Biology of Meiosis in Plants (2014)

Meiosis is the cell division that reshuffles genetic information between generations. Recently, much progress has been made in understanding this process; in particular, the identification and functional analysis of more than 80 plant genes involved in meiosis have dramatically deepened our knowledge of this peculiar cell division. In this review, we provide an overview of advancements in the understanding of all aspects of plant meiosis, including recombination, chromosome synapsis, cell cycle control, chromosome distribution, and the challenge of polyploidy.
Deformation of Polyether-Polyester Thermoelastoplastics: Mechanothermal and Structural Characterisation (2002)

The complex investigation of copoly(ether-ester) based on poly(butylene terephthalate) (PBT) and poly(tetramethylene oxide) (PTMO) reveals its microphase separated nanodomain structure. Initial morphology includes the stacks of crystalline blocks of α-PBT embedded in amorphous matrix with the different degree of continuity of the crystalline network. Two types of amorphous regions can be distinguished, the PTMO-rich phase and the other one containing the PTMO and PBT segments. Reduction of PBT content and proper decrease of its fragments length results in dramatic change in crystalline ordering, the crystallites became smaller and distorted, and more and more PBT segments are included in the amorphous phase. The initial reversible stage of deformation is controlled mostly by elastic deformation of amorphous phase, highly constrained by the network of crystallites. The further stretching results in plastic deformation and reorganisation of the crystalline blocks of PBT and a new crystalline morphology arises. Moreover, at large deformations the soft blocks of PTMO can crystallise and form very distorted paracrystalline regions. Finally, at high enough stress (≈25–30 MPa) the transition from α to β crystalline form in PBT crystal lattice occurs due to conformational changes in the tetramethylene segments. After large deformation, both the morphology and the polymer conformations are far from the equilibrium state. Annealing of the stretched samples at high temperature results in partial recovery of material properties, however the morphology is still far from the initial one even after such annealing.
Screening Effective Target Sites on mRNA: A Ribozyme Library Approach (2012)

Hammerhead ribozymes have been extensively used as RNA-inactivating agents for therapy as well as forward genomics. A ribozyme can be designed so as to specifically pair with virtually any target RNA, and cleave the phosphodiester backbone at a specified location, thereby functionally inactivating the RNA. Two major factors that determine whether ribozymes will be effective for posttranscriptional gene silencing are colocalization of the ribozyme and the target RNAs, and the choice of an appropriate target site on the mRNA. Complex secondary structures and the ability to bind to some of the cellular proteins mandate that some RNA sequences could stearically occlude binding of RNA-based antivirals like ribozymes to these sites. The use of ribozyme libraries in cell culture factors in these interactions to select for target sites on the RNA, which are more accessible to RNA-based antivirals like ribozymes or siRNA. This chapter provides a useful guide toward using ribozyme libraries to screen for effective target sites on mRNA.
Time and workload dependent device variability in circuit simulations (2011)

Simulations of an inverter and a 32-bit SRAM bit slice are performed based on an atomistic approach. The circuits' devices are populated with individual defects, which have realistic carrier-capture and emission behaviour. The wide distribution of defect time scales, accounts for both fast (Random Telegraph Noise - RTN) and near-permanent (Bias Temperature Instability - BTI) defects. The atomistic property of the model allows the detection of workload dependency in the delay of both circuits.
[The minimal effective dose of vaccine against trichophytosis in heifers]. (1991)

Calves at the age of one month were vaccinated with a lyophilized vaccine against bovine trichophytosis, or with an avirulent vaccine against bovine trichophytosis (mfd by Bioveta, Ivanovice in Haná). Prophylactic doses of the vaccines (15 mil. CFU of production strain Trichophyton verrucosum per calf) were used for immunization, and doses 10 times, 100 times and 1000 times lower. The calves were revaccinated with the same doses in 12 days after the first vaccination. Twenty-eight days later since revaccination, the vaccinated calves and a group of control nonvaccinated calves was challenged epicutaneously with a virulent strain of T. verrucosum. The protectiveness of both vaccines implanted at doses of 2 x 15 mil. and 2 x 1.5 mil. CFU per test animal was very good. No dermal lesion were observed in the challenged calves of these groups, or if any, they were not clear and could be observed for a short time. If the vaccines were used diluted at a ratio 10(-2) (150 thousand CFU of production strain), trichophytic lesions persisting for the whole period of observation were found in four of the seven calves vaccinated with a lyophilized vaccine against bovine trichophytosis and in two of the eight calves implanted an avirulent vaccine after challenge. Mycotic lesions were formed after challenge in all test animals in the groups vaccinated with doses of 2 x 15 thousand CFU of production strain per calf. The extent of these lesions was practically the same as in all nonvaccinated controls--on the surface of infected skin the hair was shed and scales and crusts were formed. A challenge strain of T. verrucosum was cultivated from these lesions.
Purification and Characterization of an NADH-Dependent Alcohol Dehydrogenase fromCandida marisfor the Synthesis of Optically Active 1-(Pyridyl)ethanol Derivatives (2011)

A novel (R)-specific alcohol dehydrogenase (AFPDH) produced by Candida maris IFO10003 was purified to homogeneity by ammonium sulfate fractionation, DEAE-Toyopearl, and Phenyl-Toyopearl, and characterized. The relative molecular mass of the native enzyme was found to be 59,900 by gel filtration, and that of the subunit was estimated to be 28,900 on SDS-polyacrylamide gel electrophoresis. These results suggest that the enzyme is a homodimer. It required NADH as a cofactor and reduced various kinds of carbonyl compounds, including ketones and aldehydes. AFPDH reduced acetylpyridine derivatives, β-keto esters, and some ketone compounds with high enantioselectivity. This is the first report of an NADH-dependent, highly enantioselective (R)-specific alcohol dehydrogenase isolated from a yeast. AFPDH is a very useful enzyme for the preparation of various kinds of chiral alcohols.
A Scalable CMOS Molecular Electronics Chip for Single-Molecule Biosensing (2022)

This work reports the first CMOS molecular electronics chip. It is configured as a biosensor, where the primary sensing element is a single molecule "molecular wire" consisting of a ∼100 GΩ, 25 nm long alpha-helical peptide integrated into a current monitoring circuit. The engineered peptide contains a central conjugation site for attachment of various probe molecules, such as DNA, proteins, enzymes, or antibodies, which program the biosensor to detect interactions with a specific target molecule. The current through the molecular wire under a dc applied voltage is monitored with millisecond temporal resolution. The detected signals are millisecond-scale, picoampere current pulses generated by each transient probe-target molecular interaction. Implemented in a 0.18 μm CMOS technology, 16k sensors are arrayed with a 20 μm pitch and read out at a 1 kHz frame rate. The resulting biosensor chip provides direct, real-time observation of the single-molecule interaction kinetics, unlike classical biosensors that measure ensemble averages of such events. This molecular electronics chip provides a platform for putting molecular biosensing "on-chip" to bring the power of semiconductor chips to diverse applications in biological research, diagnostics, sequencing, proteomics, drug discovery, and environmental monitoring.
Supplementary Materials and Methods from Synergistic Myeloma Cell Death via Novel Intracellular Activation of Caspase-10–Dependent Apoptosis by Carfilzomib and Selinexor (2023)

&lt;p&gt;Additional details of antibodies, reagents, and methods used in this manuscript.&lt;/p&gt;
Ligand-based virtual screening using binary kernel discrimination (2005)

This paper discusses the use of a machine-learning technique called binary kernel discrimination (BKD) for virtual screening in drug- and pesticide-discovery programmes. BKD is compared with several other ligand-based tools for virtual screening in databases of 2D structures represented by fragment bit-strings, and is shown to provide an effective, and reasonably efficient, way of prioritising compounds for biological screening.
EFFECTS OF CALCIUM ENTRY BLOCKERS ON BLOOD PRESSURE AND HEART RATE IN NEUROGENIC HYPERTENSIVE DOGS (1987)

The hypotensive and negative chronotropic effects of 5 calcium entry blockers (verapamil 200 micrograms/kg IV; diltiazem 300 micrograms/kg IV; nifedipine 5 micrograms/kg IV; nicardipine 50 micrograms/kg IV; and bepridil 5 mg/kg IV) were compared in control normotensive and acute neurogenic hypertensive anaesthetized dogs. Acute neurogenic hypertension was induced by sino-aortic denervation (SAD). In control normotensive dogs, all drugs (except bepridil) induced a slight and transient decrease in blood pressure. Nifedipine and nicardipine increased heart rate whereas the three other drugs remained ineffective. SAD caused a 2-2.5-fold increase in the hypotensive properties of the 5 drugs in dogs. Moreover, the duration of this induced hypotension was longer than in control normotensive animals. In SAD dogs, all calcium entry blockers significantly decreased heart rate. This study indicates that the direct cardiac inhibitory action of calcium channel blockers is modulated by baroreceptor activity in intact animals. The mechanism of the selective action of calcium entry blockers in hypertensive SAD in contrast to normotensive dogs is discussed.
Supplementary Figure 4 from Effects of HER Family–targeting Tyrosine Kinase Inhibitors on Antibody-dependent Cell-mediated Cytotoxicity in HER2-expressing Breast Cancer (2023)

&lt;p&gt;Densitometry for Figure 2B&lt;/p&gt;
Measurement of the inclusive jet cross-sections in proton-proton collisions at s = 8 $$ \sqrt{s}=8 $$ TeV with the ATLAS detector (2017)

Inclusive jet production cross-sections are measured in proton--proton collisions at a centre-of-mass energy of $\sqrt{s}=$8 TeV recorded by the ATLAS experiment at the Large Hadron Collider at CERN. The total integrated luminosity of the analysed data set amounts to $20.2$ fb$^{-1}$. Double-differential cross-sections are measured for jets defined by the anti-$k_{t}$ jet clustering algorithm with radius parameters of $R=0.4$ and $R=0.6$ and are presented as a function of the jet transverse momentum, in the range between 70 GeV and 2.5 TeV and in six bins of the absolute jet rapidity, between 0 and 3.0. The measured cross-sections are compared to predictions of quantum chromodynamics, calculated at next-to-leading order in perturbation theory, and corrected for non-perturbative and electroweak effects. The level of agreement with predictions, using a selection of different parton distribution functions for the proton, is quantified. Tensions between the data and the theory predictions are observed.
AC loss study of antiparallel connected YBCO coated conductors (2009)

Some applications of high temperature superconducting conductors require a non-inductive winding, which may be constructed from antiparallel connected YBCO (yttrium barium copper oxide) tapes. In the case of AC applications, this antiparallel winding changes the AC losses from that of an isolated conductor. This study focuses on the effect of the spatial separation and misalignment between conductors on their AC loss behavior for YBCO conductors on both rolling assisted biaxially textured substrate (RABiTS) and ion beam assisted deposition templates in an effort to fully understand the behavior of these conductors in real world applications. For RABiTS samples, the study was carried out for all three possible configurations (the so-called back-to-back, front-to-front and same-way configurations) to clarify the effect of the ferromagnetic substrate on the AC loss behavior in these conductor configurations. Numerical simulations were also employed in some cases to compare with and elucidate experimental observations.
Easily Testable Sufficient Conditions for the Robust Stability of Systems with Multiaffine Parameter Dependence (1992)

A number of robust stability problems take the following form: A polynomial has real coefficients which are multiaffine in real parameters that are confined to a box in parameter space. An efficient method is required for checking the stability of this set of polynomials. We present two sufficient conditions in this paper. They involve checking certain properties at the corners and edges of the parameter space box.
Supplementary Figure 2 from Chemotherapy Acts as an Adjuvant to Convert the Tumor Microenvironment into a Highly Permissive State for Vaccination-Induced Antitumor Immunity (2023)

&lt;p&gt;PDF file - 656K, Effect of chemotherapy on HMGB1 secretion&lt;/p&gt;
Field-free all-optical switching and electrical read-out of Tb/Co-based magnetic tunnel junctions (2023)

Switching of magnetic tunnel junction using femto-second laser enables a possible path for THz frequency memory operation, which means writing speeds 2 orders of magnitude faster than alternative electrical approaches based on spin transfer or spin orbit torque. In this work we demonstrate successful field-free 50fs single laser pulse driven magnetization reversal of [Tb/Co] based storage layer in a perpendicular magnetic tunnel junction. The nanofabricated magnetic tunnel junction devices have an optimized bottom reference electrode and show Tunnel Magnetoresistance Ratio values (TMR) up to 74\% after patterning down to sub-100nm lateral dimensions. Experiments on continuous films reveal peculiar reversal patterns of concentric rings with opposite magnetic directions, above certain threshold fluence. These rings have been correlated to patterned device switching probability as a function of the applied laser fluence. Moreover, the magnetization reversal is independent on the duration of the laser pulse. According to our macrospin model, the underlying magnetization reversal mechanism can be attributed to an in-plane reorientation of the magnetization due to a fast reduction of the out-of-plane uniaxial anisotropy. These aspects are of great interest both for the physical understanding of the switching phenomenon and their consequences for all-optical-switching memory devices, since they allow for a large fluence operation window with high resilience to pulse length variability.
Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging (2021)

During aging and neuromuscular diseases, there is a progressive loss of skeletal muscle volume and function impacting mobility and quality of life. Muscle loss is often associated with denervation and a loss of resident muscle stem cells (satellite cells or MuSCs); however, the relationship between MuSCs and innervation has not been established. Herein, we administered severe neuromuscular trauma to a transgenic murine model that permits MuSC lineage tracing. We show that a subset of MuSCs specifically engraft in a position proximal to the neuromuscular junction (NMJ), the synapse between myofibers and motor neurons, in healthy young adult muscles. In aging and in a mouse model of neuromuscular degeneration (Cu/Zn superoxide dismutase knockout - <i>Sod1<sup>-/-</sup></i>), this localized engraftment behavior was reduced. Genetic rescue of motor neurons in <i>Sod1<sup>-/-</sup></i> mice reestablished integrity of the NMJ in a manner akin to young muscle and partially restored MuSC ability to engraft into positions proximal to the NMJ. Using single cell RNA-sequencing of MuSCs isolated from aged muscle, we demonstrate that a subset of MuSCs are molecularly distinguishable from MuSCs responding to myofiber injury and share similarity to synaptic myonuclei. Collectively, these data reveal unique features of MuSCs that respond to synaptic perturbations caused by aging and other stressors.