gebhart/patrepeval huggingface dataset:
Markers close to the dopamine D5 receptor gene (DRD5) show significant association with schizophrenia but not bipolar disorder (2001)

Following the description of linkage of markers at chromosome 4p16 to bipolar disorder in several families [Blackwood et al., 1996], and the association of the alleles of a polymorphism closely linked to D5 dopamine receptor gene with schizophrenia [Williams et al., 1997], we have looked for linkage disequilibrium between a series of microsatellite markers from this region and major psychoses including schizophrenia, bipolar disorder, and unipolar major depressive disorder. A significant increase in the frequency of the 148 bp allele of DRD5 (P = 0.024) and the 244 bp allele of D4S615 (P = 0.001) was found in patients with schizophrenia (n = 158 DRD5; n = 133 D4S615), compared with patients with bipolar disorder (n = 270 DRD5; n = 107 D4S615), or controls without psychiatric illness (n = 437 DRD5; n = 309 D4S615). The frequency of the 148 bp allele of DRD5 was also increased in schizophrenia over unipolar major depressive disorder (n = 65). D4S615 was not typed in unipolar disorder. The estimated odds ratios confirmed that the 148 bp allele of DRD5 and the 244 bp allele of D4S615 conferred increased risk of schizophrenia. Estimated Haplotype (EH) analysis of 174 controls and 128 patients with schizophrenia who were typed for both markers confirmed the strong associations with these alleles but did not show evidence that the markers were in linkage disequilibrium with each other even though they lie approximately 150 kb apart. The data are consistent with an association between markers close to the D5 dopamine receptor and schizophrenia, but not bipolar disorder or unipolar major depression.
A simple set of grasps for a dextrous hand (2005)

This paper describes a high-level control mechanism for a dextrous hand. It overviews a distributed environment for robot control currently under development. A simple flexible set of grasps for a dextrous hand is then suggested and their implementation discussed. Finally the paper speculates about the role the grasp can play in obstacle avoidance and vice-versa.
Diastereoselectivity in cyclopropanation and epoxidation reactions of chiral (E)-crotylsilanes: Asymmetric synthesis of substituted tetrahydrofurans (1994)

Functionalized (E)-crotylsilanes 1 bearing a bis-homoallylic hydroxyl group undergo diastereoselective cyclopropanation and epoxidation reactions to produce substituted tetrahydrofurans 3 and 5 respectively after an acid catalyzed heterocyclization.
Phase-field modelling for fatigue crack growth under laser shock peening-induced residual stresses (2021)

Abstract For the fatigue life of thin-walled components, not only fatigue crack initiation, but also crack growth is decisive. The phase-field method for fracture is a powerful tool to simulate arbitrary crack phenomena. Recently, it has been applied to fatigue fracture. Those models pose an alternative to classical fracture-mechanical approaches for fatigue life estimation. In the first part of this paper, the parameters of a phase-field fatigue model are calibrated and its predictions are compared to results of fatigue crack growth experiments of aluminium sheet material. In the second part, compressive residual stresses are introduced into the components with the help of laser shock peening. It is shown that those residual stresses influence the crack growth rate by retarding and accelerating the crack. In order to study these fatigue mechanisms numerically, a simple strategy to incorporate residual stresses in the phase-field fatigue model is presented and tested with experiments. The study shows that the approach can reproduce the effects of the residual stresses on the crack growth rate.
Drug-Loaded Microbeads Sandwiched Between Nanofiber Layers for Extended Linear Release (2020)

Fabrication of a triple-layered membrane consisting of a dexamethasone (DX)-loaded polycaprolactone (PCL) microbead layer sandwiched between two PCL nanofiber layers is demonstrated for highly extended linear drug release with low initial burst. Dual syringe sequential electrospinning is used to produce the triple layers. A linear drug release of over 80 days and a significantly reduced initial burst of less than 30% is reported. With the dual syringe electrospinning system, more degrees of freedom in the fabrication of a membrane with a customizable release profile can be realized.
New simple prognostic score for primary biliary cirrhosis: Albumin‐bilirubin score (2015)

The ALBI score is readily derived from a blood test without using those factors evaluated subjectively or obtained by invasive procedures. It is an independent prognostic factor for PBC patients and provides better/similar prognostic performance compared with other prognostic scores.
Potentials of AI in medical image analysis in Gastroenterology and Hepatology (2020)

With the advancement of artificial intelligence (AI) technology, it comes in a big wave carrying possibly huge impact in the field of medicine. Gastroenterology and hepatology, being a specialty relying much on diagnostic imaging, endoscopy, and histopathology, AI technology has promised improving the quality and consistency of care to the patients. In this review, we will elucidate the development of machine learning methods, especially the visual representation mechanism in deep learning on recognition tasks. Various AI-image analysis applications in endoscopy, radiology, and pathology are covered in gastroenterology and hepatology and reveal the enormous potentials for AI in assisting diagnosis, prognosis, and treatment. We also discuss the promises as well as pitfalls for AI in medical image analysis and pointing out future research directions.
Privacy-preserving sharing and correction of security alerts (2004)

We present a practical scheme for Internet-scale collaborative analysis of information security threats which provides strong privacy guarantees to contributors of alerts. Wide-area analysis centers are proving a valuable early warning service against worms, viruses, and other malicious activities. At the same time, protecting individual and organizational privacy is no longer optional in today's business climate. We propose a set of data sanitization techniques and correlation, while maintaining privacy for alert contributors. Our approach is practical, scalable, does not rely on trusted third parties or secure multiparty computation schemes, and does not require sophisticated schemes, and does not require sophisticated key management.
Gene therapy for malignant brain tumors (2003)

Malignant primary and metastatic brain tumors have remained fatal in spite of major advances in diagnostic tools and the improvement of conventional therapies. Recent discoveries in the molecular basis of the disease have allowed increased understanding of the events that lead to the development of brain tumors and have also brought a new spectrum of alternatives for treatment. By using gene therapy, brain tumors can be treated by targeting their fundamental molecular defects, delivering gene-drugs to the malignant cells. The possible targets for this type of treatment are progressively increasing but abundant clinical success has yet to be obtained, in part due to imperfect delivery systems. In this review, the genetic fundamentals of various cerebral neoplasms and neurogenetic syndromes, different strategies used for gene therapy, various available DNA delivery systems, status of ongoing clinical trials, and possible prospects for the futureare discussed.
Color printing on pre-colored textiles (2021)

Managing color on a particular imaging system is a wellunderstood challenge with a wealth of existing models, methods and techniques. In the case of printing systems, these tend to operate in the context of a single substrate, where managing color on every additional substrate is approach as a separate, detached problem. While such a mind-set works reasonably well in general, it breaks down when it comes to printing onto precolored textiles, such as pre-dyed fabrics. The present paper therefore introduces a family of approaches that support the use of multiple pre-colored textiles on a given printing system that also allow for a balance between characterization effort and color match accuracy. This, in turn provides solutions that can fit a variety of practical working patterns to maximize overall efficiency and performance.
G0200204 Elastic Modulus and Micro Structure Variation from Surface to Inner Region in Bovine Cortical Bone (2015)

Mechanical properties of bone are essential to understand the changes in bone fracture risk with aging and/or osteoporosis and to evaluate the effects of osteoporotic medicines as well as bone volume fraction and bone mineral density. The relationship between mechanical properties and hierarchical structure of cortical bone has been investigated using the bone samples taken from an inner region of the diaphysis. According to an optical microscopic observation, different microstructure was observed between cortical surface and inner region of the diaphysis. Hence, the study aimed to investigate the distributions of elastic modulus, microstructure, hydroxyapatite (HAp) crystal orientation, and mineral contents from the cortical surface to the inner region of the bovine femoral diaphysis. In the experiments, strip bone specimens were taken from the surface and the inner region of bovine femoral diaphyses. As a result, elastic modulus at the surface region was significantly lower than that in the inner region (73%). Osteon area fraction at the surface region was significantly lager than that in the inner region (141%). On the other hand, HAp crystal orientation showed no significant difference. Mineral contents at the surface were slightly lower than that in the inner region (98%). It suggests that elastic modulus of osteon region is lower than that of non-osteon region and that the difference of elastic modulus between surface and inner region may depend on the osteon area fraction as well as mineral contents.
Effect of Using Fluorinated Ether and Sulfone as Electrolyte Solvents for Lithium Ion Batteries with Lithium-Rich Layered Cathodes and Silicon Oxide Anodes (2017)

We examined fluorinated ether and sulfone as electrolyte solvents for Lithium (Li) ion batteries with Li-rich layered cathodes and Silicon oxide anodes. We evaluated the mixture of cyclic carbonate, sulfone compound, and 1,1,2,2-tetrafluoroethyl 2,2,3,3-tetrafluoropopyl ether (FE1). The gas volume after the initial charge-discharge process increased with the amount of ethylene carbonate (EC) or 4-fluoro 1,3-dioxolane 2-one (FEC). These results show that the reaction between EC or FEC and cathode-active material can be considered to be the cause of gas evolution in the initial charge-discharge cycle. We evaluated sulfone compounds and low-viscosity solvents. By using electrolyte solution with ethyl isopropyl sulfone, FE1, and FEC as electrolyte solvents, the retention capacity after 500 cycles increased to around 67%, which was larger than that of conventional electrolyte solutions such as 1 M LiPF6 EC/diethyl carbonate (30/70 v/v).
Geiger-mode APD camera system for single-photon 3D LADAR imaging (2012)

The unparalleled sensitivity of 3D LADAR imaging sensors based on single photon detection provides substantial benefits for imaging at long stand-off distances and minimizing laser pulse energy requirements. To obtain 3D LADAR images with single photon sensitivity, we have demonstrated focal plane arrays (FPAs) based on InGaAsP Geiger-mode avalanche photodiodes (GmAPDs) optimized for use at either 1.06 &mu;m or 1.55 &mu;m. These state-of-the-art FPAs exhibit excellent pixel-level performance and the capability for 100% pixel yield on a 32 x 32 format. To realize the full potential of these FPAs, we have recently developed an integrated camera system providing turnkey operation based on FPGA control. This system implementation enables the extremely high frame-rate capability of the GmAPD FPA, and frame rates in excess of 250 kHz (for 0.4 &mu;s range gates) can be accommodated using an industry-standard CameraLink interface in full configuration. Real-time data streaming for continuous acquisition of 2 &mu;s range gate point cloud data with 13-bit time-stamp resolution at 186 kHz frame rates has been established using multiple solid-state storage drives. Range gate durations spanning 4 ns to 10 &mu;s provide broad operational flexibility. The camera also provides real-time signal processing in the form of multi-frame gray-scale contrast images and single-frame time-stamp histograms, and automated bias control has been implemented to maintain a constant photon detection efficiency in the presence of ambient temperature changes. A comprehensive graphical user interface has been developed to provide complete camera control using a simple serial command set, and this command set supports highly flexible end-user customization.
Webdocumentaire et ressources numériques applicables à la mise en scène, à la délinéarisation et à l’interactivité. (2016)

Le webdocumentaire a pour caractéristique d’intégrer les particularités de ses deux composantes. L’intégration de la forme numérique par le documentaire et son rapprochement du média internet induisent donc de nouvelles ressources d’écriture. Celles-ci peuvent revisiter le genre documentaire, mais aussi s’ouvrir à la puissance des réseaux informatiques et sociaux. Nous proposons de repérer les tendances de la production de webdocumentaires en inscrivant notre investigation dans la continuité de l’histoire des régimes de vision introduits par la vidéographie numérique, et l’avènement de l’hypermédia et des images algorithmiques. Dans le passé, un renouvellement des dispositifs techniques automatiques liés au cinéma, à la vidéographie analogique et à l’infographie, a entraîné une reproduction des tendances dominantes et un développement marginal de nouvelles écritures. Nous chercherons à repérer si l’hybridation d’un genre confirmé, le documentaire, et du web, a favorisé le rapprochement de la marge vers le centre, en remettant en cause les écritures initiales et en favorisant l’émergence de nouveaux « principes » créatifs.
Structure-Based Design of Molecules to Reactivate Tumor Derived p53 Mutations (2005)

Abstract : Of the genetic alterations associated with breast cancer, changes in p53 are the most frequently identified and a subset of these changes destabilize the p53 core domain structure. The overall goal of our studies is to identify small molecule compounds that bind and stabilize this subset of tumor-derived p53 mutants. We anticipate that the identification of such compounds will serve as a scaffold for the preparation of small molecule drugs for the treatment of p53-mediated breast cancer. Towards this goal, we have published studies where we have employed a Multiple Solvent Crystal Structures (MSCS) technique to identify a p53 binding sites for the small molecule compound tris(hydroxymethyl)aminomethane (Tris) and have used both solution studies and molecular dynamics simulations to show that Tris binding increases the stability of the p53 core domain. We have more recently carried out virtual screening (in silico) to identify Tris analogues that are predicted to have improved p53 core domain binding and stability properties. In the future, we will continue the virtual screening studies and test our virtual screening hits in solution for improved p53 core domain binding and stability. We will also cocrytallize the p53 core domain with the Tris analogues that show the most favorable properties for second generation structure-based optimization of these compounds.
A New Prosthesis for the Metacarpophalangeal Joint (1999)

This report discusses the Daphne prosthesis for the metacarpophalangeal joint on the basis of the mechanical, chemical and biological performance of the materials employed. The Daphne prosthesis is a mobile device. The main body is made of a new generation polymethylmetacrylate, while the hinge is made of AISI 316 L stainless steel. Biocompatibility tests were performed on the materials employed. Systemic toxicity, cytotoxicity and contact tests have given favourable results. Mechanical engineering tests have been used to investigate the performances and reliability of the selected materials. The polymethylmetacrylate used in Daphne behaves in a ductile fashion. No mechanical failures were encountered in fatigue tests after 10 million cycles.
Monocular Image Based 3D Model Retrieval (2019)

Monocular image based 3D object retrieval is a novel and challenging research topic in the field of 3D object retrieval. Given a RGB image captured in real world, it aims to search for relevant 3D objects from a dataset. To advance this promising research, we organize this SHREC track and build the first monocular image based 3D object retrieval benchmark by collecting 2D images from ImageNet and 3D objects from popular 3D datasets such as NTU, PSB, ModelNet40 and ShapeNet. The benchmark contains classified 21,000 2D images and 7,690 3D objects of 21 categories. This track attracted 9 groups from 4 countries and the submission of 20 runs. To have a comprehensive comparison, 7 commonly-used retrieval performance metrics have been used to evaluate their retrieval performance. The evaluation results show that the supervised cross domain learning get the superior retrieval performance (Best NN is 97.4 %) by bridging the domain gap with label information. However, there is still a big challenge for unsupervised cross domain learning (Best NN is 61.2%), which is more practical for the real application. Although we provided both view images and OBJ file for each 3D model, all the participants use the view images to represent the 3D model. One of the interesting work in the future is directly using the 3D information and 2D RGB information to solve the task of monocular Image based 3D model retrieval.
Robust Face Detection Combined Skin Color Features, Template Matching and VQ Histogram Method in Practical Environments (2004)

Abstract The face detection in complex background is still difficult by existing techniques. We present an approach to real-time face detection in practical environrnents using multi-module integration. We combine color extraction module, geometrical method, template-based module and face recognition module named VQ histogram method into a single robust face detection system. First, the skin color is used to locate the skin color areas and possible face candidates aze extracted by geometrical constraints, then template matching is carried out using appropriate-sized templates to extract the point of face, fmally a very simple yet highly reliable face recognition method called VQ histogram method is utilized to verify whether it is the face or not. The method is proved very effective in a practical environrnent.
Async-RED: A Provably Convergent Asynchronous Block Parallel Stochastic Method using Deep Denoising Priors (2020)

Regularization by denoising (RED) is a recently developed framework for solving inverse problems by integrating advanced denoisers as image priors. Recent work has shown its state-of-the-art performance when combined with pre-trained deep denoisers. However, current RED algorithms are inadequate for parallel processing on multicore systems. We address this issue by proposing a new asynchronous RED (ASYNC-RED) algorithm that enables asynchronous parallel processing of data, making it significantly faster than its serial counterparts for large-scale inverse problems. The computational complexity of ASYNC-RED is further reduced by using a random subset of measurements at every iteration. We present complete theoretical analysis of the algorithm by establishing its convergence under explicit assumptions on the data-fidelity and the denoiser. We validate ASYNC-RED on image recovery using pre-trained deep denoisers as priors.
Eight-Year Follow-Up of an Initial Case with NF-?B Decoy Oligodeoxynucleotide Transfection After Coronary Stent Implantation (2012)

Background: Nuclear factor–kappa B (NF-kB) plays a pivotal role in vascular remodeling after percutaneous coronary intervention (PCI) with a stent implantation. Methods and Results: This is the first clinical report to demonstrate the effect of NF-kB decoy oligodeoxynucleotide (ODN) on the prevention of restenosis after an eight-year observation period. We revealed that decoy ODN treatment suppressed neointimal formation in comparison to that without ODN transfected stent lesion in the same artery. Conclusion: We showed the long-term usefulness of NF-kB decoy ODN transfer after PCI. Keywords: CT, coronary intervention, gene therapy, nuclear factor–kappa B, oligodeoxynucleotide, restenosis, stents
Discovering patterns to extract protein-protein interactions from full biomedical texts (2004)

Although there have been many research projects to extract protein pathways, most such information still exists only in the scientific literature, usually written in natural languages and defying data mining efforts. We present a novel and robust approach for extracting protein-protein interactions from the literature. Our method uses a dynamic programming algorithm to compute distinguishing patterns by aligning relevant sentences and key verbs that describe protein interactions. A matching algorithm is designed to extract the interactions between proteins. Equipped only with a protein name dictionary, our system achieves a recall rate of about 80.0% and a precision rate of about 80.5%.
The preliminary results on Direct Torque Control for an fractional-slot concentrated winding Interior Permanent Magnet Synchronous Machine (2012)

This paper reports results of investigation of the Direct Torque Control (DTC) technique to an fractional-slot Interior Permanent Magnet Synchronous Machine (IPMSM) with concentrated windings (CW). Application of concentrated winding to IPM machine is gaining attention from research community because of its advantages such as high-power density, high efficiency, short end-turns, wider flux-weakening capability, fault tolerance, robust rotor, and presence of additional reluctance torque component, and, the major disadvantage is of non-sinusoidal magnetomotive force (MMF). However, using appropriate combination of slot and pole, sinusoidal EMF and low cogging torque can be achieved despite presence of MMF harmonics. A 14-pole, 18-slot, double layer concentrated winding IPM had been designed and constructed at the University of the New South Wales. The DTC was applied to the prototype machine. In DTC scheme, the requirement of the continuous rotor position sensor and coordinate transformation between stationary and rotating (dq) reference frame is eliminated since all of the calculation is done in stator reference frame. The speed is estimated from the stator flux linkage vectors and the torque angle. The performances of the DTC control scheme is evaluated in terms of torque and current ripple, transient response to step variations of the speed command and load disturbances at maximum torque per ampere and field weakening regions. The experiment results presented clearly demonstrate effectiveness of DTC in IPMSM with CW.
Synthesis of a novel bruceantin analog via intramolecular etherification (2020)

Reaction of the known bruceantin-derived carbinol 6 with triflic anhydride and pyridine leads to the formation of a novel hexacyclic structure 8 that results from an intramolecular etherification.