gebhart/patrepeval huggingface dataset:
IL-1α and IL-1β Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation (2011)

The immune system has evolved to protect the host from invading pathogens and to maintain tissue homeostasis. Although the inflammatory process involving pathogens is well documented, the intrinsic compounds that initiate sterile inflammation and how its progression is mediated are still not clear. Because tissue injury is usually associated with ischemia and the accompanied hypoxia, the microenvironment of various pathologies involves anaerobic metabolites and products of necrotic cells. In the current study, we assessed in a comparative manner the role of IL-1α and IL-1β in the initiation and propagation of sterile inflammation induced by products of hypoxic cells. We found that following hypoxia, the precursor form of IL-1α, and not IL-1β, is upregulated and subsequently released from dying cells. Using an inflammation-monitoring system consisting of Matrigel mixed with supernatants of hypoxic cells, we noted accumulation of IL-1α in the initial phase, which correlated with the infiltration of neutrophils, and the expression of IL-1β correlated with later migration of macrophages. In addition, we were able to show that IL-1 molecules from cells transfected with either precursor IL-1α or mature IL-1β can recruit neutrophils or macrophages, respectively. Taken together, these data suggest that IL-1α, released from dying cells, initiates sterile inflammation by inducing recruitment of neutrophils, whereas IL-1β promotes the recruitment and retention of macrophages. Overall, our data provide new insight into the biology of IL-1 molecules as well as on the regulation of sterile inflammation.
Histone Deacetylase (HDAC) Inhibitor LBH589 Increases Duration of γ-H2AX Foci and Confines HDAC4 to the Cytoplasm in Irradiated Non–Small Cell Lung Cancer (2006)

Histone deacetylases (HDAC) have been identified as therapeutic targets due to their regulatory function in DNA structure and organization. LBH589 is a novel inhibitor of class I and II HDACs. We studied the effect of LBH589 and ionizing radiation (IR) on DNA repair in two human non-small cell lung cancer (NSCLC) cell lines (H23 and H460). gamma-H2AX foci present at DNA double-strand breaks (DSBs) were detected in the nuclei following 3 Gy irradiation for up to 6 hours. LBH589 administered before irradiation increased the duration of gamma-H2AX foci beyond 24 hours. Furthermore, radiation alone induced translocation of HDAC4 to the nucleus. In contrast, treatment with LBH589 followed by irradiation resulted in HDAC4 confinement to the cytoplasm, indicating that HDAC inhibition affects the nuclear localization of HDAC4. The findings that LBH589 confines HDAC4 to the cytoplasm and increases the duration of gamma-H2AX foci in irradiated cell lines suggest that HDAC4 participates in DNA damage signaling following IR. Annexin-propidium iodide flow cytometry assays, cell morphology studies, and cleaved caspase-3 Western blot analysis revealed a synergistic effect of LBH589 with IR in inducing apoptosis. Clonogenic survival showed a greater than additive effect when LBH589 was administered before irradiation compared with irradiation alone. In vivo tumor volume studies showed a growth delay of 20 days with combined treatment compared with 4 and 2 days for radiation or LBH589 alone. This study identifies HDAC4 as a biomarker of LBH589 activity and recognizes the ability of LBH589 to sensitize human NSCLC to radiation-induced DNA DSBs.
Text entry from power wheelchairs: edgewrite for joysticks and touchpads (2003)

Power wheelchair joysticks have been used to control a mouse cursor on desktop computers, but they offer no integrated text entry solution, confining users to point-and-click or point-and-dwell with on-screen keyboards. But on-screen keyboards reduce useful screen real-estate, exacerbate the need for frequent window management, and impose a second focus of attention. By contrast, we present two integrated gestural text entry methods designed for use from power wheelchairs: one for joysticks and the other for touchpads. Both techniques are adaptations of EdgeWrite, originally a stylus-based unistroke method designed for people with tremor. In a preliminary study of 7 power wheelchair users, we found that touchpad EdgeWrite was faster than joystick WiVik, and joystick EdgeWrite was only slightly slower after minimal practice. These findings reflect "walk up and use"-ability and warrant further investigation into extended use.
A Case of Lysosomal Acid Lipase Deficiency Confirmed by Response to Sebelipase Alfa Therapy (2020)

Lysosomal acid lipase (LAL) deficiency, or cholesterol ester storage disease, is a disorder affecting the breakdown of cholesterol esters and triglycerides within lysosomes. Clinical findings include hepatomegaly, hepatic dysfunction, and dyslipidemia with a wide range of phenotypic variability and age of onset. The available clinical and molecular information of the patient presented herein was consistent with a diagnosis of LAL deficiency, but her LAL activity assay repeatedly showed normal or borderline low results. Her response to enzyme replacement therapy and demonstrable deficiency on a newer specific enzymatic assay ultimately confirmed her diagnosis of LAL deficiency.
Left-Upper-Quadrant Devascularization for 'Unshuntable' Portal Hypertension (1996)

Left-upper-quadrant devascularization is a technically straightforward, safe, effective, and durable alternative to the Sugiura procedure or to radical esophagogastrectomy in patients with unshuntable portal hypertension.
Quantitative and qualitative effects of bioaugmentation on ammonia oxidisers at a two-step WWTP (2010)

Large waste water treatment plants (WWTP) often operate nitrification in two different process environments: the cold-dilute sewage is treated in the mainstream nitrification/denitrification system, while the high strength ammonia liquors from sludge dewatering are treated in a separate high temperature reactor (SBR). This study investigates transfer from nitrifier biomass into a two-stage WWTP, commonly referred to as bioaugmentation. Besides the quantitation of ammonia oxidising bacteria (AOB), community differences were analysed with two techniques, denaturing gradient gel electrophoresis and real-time PCR melt curve analysis. It was shown that, without bioaugmentation, two distinct AOB communities establish in the mainstream and in the SBR, respectively. A gradual shift of the two AOB communities with increasing pump rates between the systems could be demonstrated. These molecular findings support process engineering experience, that cycling of waste activated sludge improves the ability of AOB to adapt to different process environments.
SAW: Spectrum Assignment for WLANs (2013)

1 We consider the problem of jointly allocating channel center-frequencies and bandwidths for IEEE 802.11 wireless LANs (WLANs). The bandwidth used on a link significantly affects both the capacity experienced on this link and the interference produced on neigh-boring links. Therefore, when jointly assigning both center fre-quencies and channel widths, a trade-off must be found between interference mitigation and the potential capacity offered on each link. We study this trade-off and present SAW (spectrum assign-ment for WLANs), a decentralized algorithm that finds efficient configurations. SAW is tailored for 802.11 home networks. It is distributed, on-line and transparent. It does not require a central coordinator and it constantly adapts the spectrum usage without disrupting network traffic. The algorithm is decentralized and self-organizing; it prov-ably converges towards efficient spectrum allocations. We evaluate SAW using both simulation and a deployment on an indoor testbed composed of off-the-shelf 802.11 hardware. We observe that it dramatically increases the overall network efficiency and fairness, even when some Access Points (APs) do not behave socially.
Synthetic chenodeoxycholic acid derivative HS-1200-induced apoptosis of p815 mastocytoma cells is augmented by co-treatment with lactacystin (2003)

The antitumor activity of a synthetic chenodeoxycholic acid derivative, HS-1200, on the p815 mastocytoma cell line was investigated. We present several lines of evidence indicating that HS-1200 at 35 μM induced apoptosis of p815 cells. Reduction of mitochondrial membrane potential, the release of cytochrome c to cytosol, activation of caspase-3, nuclear condensation, production of poly(ADP-ribose) polymerase cleavage, generation of DNA fragmentation and nuclear condensation were demonstrated. Importantly, HS-1200 inhibited proteasome activity. Next, the combination treatment of HS-1200 or a proteasome inhibitor lactacystin was undertaken. Although the single treatment of 20 μM HS-1200 or 1 μM lactacystin induced apoptosis slightly, the combination treatment of them augmented prominently the extent of apoptosis. The combination therapy of HS-1200 and lactacystin could be potentially a therapeutic strategy reducing the extent and severity of treatment-related toxicity.
Design and development of a high-performance passive millimeter-wave imager for aeronautical applications (2005)

We describe a high performance optomechanically scanned millimeter-wave imager intended to monitor the ground movement of aircraft in adverse weather conditions. It employs two counter-rotating mirrors that are tilted about their axes of rotation. They simulate the linear scan of a single high speed, large aperture flapping mirror. When used with a linear receiver array, they can produce a 2-D scan of the scene at TV rates. In the present application, they were used with a single receiver and a large flapping mirror to produce a 2-D scan of the scene ±10 deg vertically and 60 deg horizontally. One of the rotating mirrors has a concave surface and acts as the focusing element in the imager. The two mirrors are driven from a single servo motor using timing belts and toothed pulleys. The flapping mirror is slaved to the motion of the rotating disks using an electronic cam. The single channel 94-GHz receiver consisted of an InP LNA followed by a down converter and a detector. The video output passes to an A/D converter and is displayed on a conventional PC. This system has virtually 100% transmission and can be used at any waveband.
DNA cloning: A personal view after 40 years (2013)

In November 1973, my colleagues A. C. Y. Chang, H. W. Boyer, R. B. Helling, and I reported in PNAS that individual genes can be cloned and isolated by enzymatically cleaving DNA molecules into fragments, linking the fragments to an autonomously replicating plasmid, and introducing the resulting recombinant DNA molecules into bacteria. A few months later, Chang and I reported that genes from unrelated bacterial species can be combined and propagated using the same approach and that interspecies recombinant DNA molecules can produce a biologically functional protein in a foreign host. Soon afterward, Boyer's laboratory and mine published our collaborative discovery that even genes from animal cells can be cloned in bacteria. These three PNAS papers quickly led to the use of DNA cloning methods in multiple areas of the biological and chemical sciences. They also resulted in a highly public controversy about the potential hazards of laboratory manipulation of genetic material, a decision by Stanford University and the University of California to seek patents on the technology that Boyer and I had invented, and the application of DNA cloning methods for commercial purposes. In the 40 years that have passed since publication of our findings, use of DNA cloning has produced insights about the workings of genes and cells in health and disease and has altered the nature of the biotechnology and biopharmaceutical industries. Here, I provide a personal perspective of the events that led to, and followed, our report of DNA cloning.
Modeling and simulation of RLC interconnect effects with the AWE method (2005)

Analysis of RLC interconnect circuit models with initial conditions and non-monotone response waveforms requires a more comprehensive waveform simulator. AWE is a generalized approach to approximating the waveform response of linear circuits with multiple steps and ramp input signals as well as unrestricted nonequilibrium initial conditions. In this paper AWE method is used to model and simulate interconnect effects such as time delay, overshoot and crosstalk. These new distributed models reveal that peak crosstalk voltage is over 60% larger for 5 GHz high-speed interconnects than predicted by current distributed RC models.
Low-frequency underwater sound generation by impacting transient cylindrical water jets (1993)

The impact of a jet of water onto a still-water surface results in the entrainment of large amounts of air and the eventual formation of a bubble plume. Results from an experimental study of the noise produced by this process is presented. Preliminary results of this study were reported previously by Kolaini et al. [J. Acoust. Soc. Am. 89, 2452–2455 (1991)]. The densely populated bubble plumes were generated by dropping a fixed volume of water, held in a cylindrical container, onto a still-water surface. High-speed video images reveal the formation of a cylindrical bubble plume with a very high void fraction which grows in size until all the water is injected into the tank. As the leading end of the plume advances, a section of the plume separates near the crater region formed by the jet. After detachment, the separated plume, which is roughly spherical in shape, undergoes volume pulsations, and radiates relatively large-amplitude, low-frequency sound. The nature of the acoustic emissions from bubble plumes depends on the height of the water in the container, the container’s radius, and the velocity of the impacting jet. The natural frequency of oscillation of an individual bubble plume is inversely proportional to the radius of the plume and ranges from a few tens of Hz to over 100 Hz depending upon the void fraction of air contained within the plume. Results obtained with salt water as well as with rough jets are also discussed. The high-speed video observations reveal that immediately following the bubble plume detachment, there is evidence of an axial jet directed downward into the bubble plume and an opposing jet directed upward into the crater formed by the impact. This jet appears to be the physical mechanism that drives the cloud into oscillation. Measurements indicate that the acoustic intensity radiated from bubble plumes correlate with the total potential energy of the water jet.
VGCF an Alternative Carbon Conductor for Li-ion Technology (2006)

Abstract not Available.
Numerical Analysis of Natural Foundation Settlement under Different Subgrade Height in the Yellow River Flood Area (2014)

Foundation subsidence is an important factor affecting the life of the highway, as well as one of the important evaluation indicators of the foundation disposal measures. In this paper, by selecting typical foundations of Jile express highway, FLAC3D was used to simulate the natural foundation settlement under different subgrade height considering the impact of groundwater levels in the Yellow River flood area. The relationship between the time T (Month) from subgrade construction completed to stabilization and the subgrade height H was found as: T=0.36H 2 -1.63H+33.47, and the appropriate value of time was got to be placed under different circumstances.
[Therapeutic drug monitoring: clinical practice]. (2008)

When requesting a blood level measurement in the context of "Therapeutic drug monitoring" (TDM), numerous aspects have to be considered in the pre-analytical and analytical area, as in the integration of associated clinical data. This review presents therapeutic classes for which a clinical benefit of TDM is established or suggested, at least in some settings. For each class of drugs, the main pharmacokinetic, pre-analytical, analytical and clinical aspects are evaluated in the scope of such a monitoring. Each step of the TDM process is important and none should be neglected. Additional clinical trials are however warranted to better establish the exact conditions of use for such a monitoring.
Control of Surface Plasmon Localization via Self-Assembly of Silver Nanoparticles along Silver Nanowires (2008)

A simple and low-cost method to create metal-metal hybrid nanostructures possessing fairly regularly spaced "hot-spots" of surface plasmon resonances is proposed. The nanohybrid structure was prepared via self-assembly during a simple drop-casting procedure, using chemically synthesized silver nanowires and silver nanoparticles prepared in a single batch of a polyol process. Wide field illumination of these nanohybrids produced hot-spots with spacings of around 500 nm to 1 microm. The intensity of the emission/scattering from the hot-spots fluctuates over time. The proposed structure can be useful for the development of molecular-sensors or as a substrate for surface enhanced Raman/fluorescence spectroscopy.
ChemInform Abstract: Influence of Hydrocarbon Chain Length and Zeolite Structure on the Catalyst Activity and Deactivation for n‐Alkane Cracking (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A New Beamforming Design for Multicast Systems (2012)

In this paper, we study a transmit beamforming technique for multiple-input–multiple-output (MIMO) downlink multicast systems. Assuming that channel state information (CSI) is available at a transmitter, we try to maximize the lowest transmit data rate among users for a given transmit power level. Since finding the optimal beamforming vector requires prohibitively high computational complexity, we propose a reduced complexity scheme by applying greedy vector search and a simple power-allocation (PA) algorithm. Simulation results show that the proposed scheme outperforms the conventional semidefinite relaxation (SDR) technique and provides a performance quite close to the optimal performance with much reduced complexity.
Conversion of Esters to Allylsilanes: Trimethyl(2‐Methylene‐4‐Phenyl;3‐Butenyl)Silane (2003)

Abstract Conversion of Esters to Allylsilanes: Trimethyl(2‐Methylene‐4‐Phenyl‐3‐Butenyl)Silane product: trimethyl(2‐methylene‐4‐phenyl‐3‐butenyl)silane byproduct: 3‐methyl‐1‐phenyl‐1,3‐butadiene
Adapting large-area flexible hybrid TFT/CMOS electronics and display technology to create an optical sensor array architecture (2017)

This work presents a hybrid TFT/CMOS circuit architecture that integrates a flexible thin-film transistor (TFT) active matrix optical sensor array with peripheral CMOS drive circuitry for optical image capture, combined with the development of a complete optical image acquisition system. This configuration was then used to capture optical test images from a representative flexible 128 column × 240 row TFT array of imaging pixels. Test results demonstrated the ability to capture full 12-bit grayscale optical images from the flexible sensor array.
1 ms column parallel vision system and its application of high speed target tracking (2002)

We have developed a 1 ms vision system, to provide a much faster frame rate than that of the conventional systems. Our 1 ms vision system has a 128/spl times/128 PD array and an all parallel processor array connected to each other in a column parallel architecture, so that the bottleneck of an image transfer is solved. 1 ms visual feedback has been realized in this system, in which the image feature value is extracted in 1 ms cycle-time for visual servoing. We have also developed a high speed active vision system (AVS)-II. Finally, we provide a detail discussion on our 1 ms vision system and its performance through some experiments.
Improvement of driving efficiency of ultrasonic motor by improvement of vibration configuration (2014)

An ultrasonic motor is generally composed of a vibrator and a rotor, and is driven by the frictional force between the vibrator/rotor. Since the contact points on the vibrator draw elliptic trajectory, relative speed of the point against the rotor varies even when the rotor rotates with a constant speed. This may cause abrasion between the vibrator/rotor and decrease in driving efficiency. This research proposes a novel method to reduce the relative speed to improve the driving efficiency of ultrasonic motors by superimposing harmonic vibrations with driving vibration. Results of numerical calculation show that driving efficiency may be improved by 27% by the proposed method.
Polystyrene–Poly(propylene imine) Dendrimers: Synthesis, Characterization, and Association Behavior of a New Class of Amphiphiles (1996)

Abstract A new class of amphiphilic macromolecules has successfully been synthesized by creating well‐defined diblock copolymers of polystyrene (PS, M n 3.2 × 10 3 , M w / M n =1.04) with poly‐(propylene imine) dendrimers. A poly‐styrene core molecule with a primary amine end‐group was prepared by a quantitative three‐step modification procedure of acid‐functionalized polystyrene. On this core molecule, five different generations from PS‐ dendr ‐NH 2 up to PS‐ dendr ‐(NH 2 ) 32 were constructed in high yields. The molecular structure of the block co‐polymers was analyzed in detail with NMR and IR spectroscopy and electrospray mass spectrometry. With conductivity measurements and monolayer pressure–area isotherm determinations, we observed generation‐dependent amphiphilic behavior. Dynamic light scattering and transmission electron microscopy showed that amphiphile geometry had a distinct effect on aggregation behavior; this is in qualitative agreement with Israelachvili's theory. Critical association concentrations determined with the pyrene probe luminescence technique were as low as 5 × 10 ‐7 M. The amphiphiles presented here, therefore, show a resemblance to traditional block copolymers with regard to size and stability, and are similar to surfactants with respect to tuning of the shape.
가자미피 (皮) 젤라틴 제조를 위한 전처리 방법의 검토 (1992)

In order to reduce long preparating time for alkali pretreated B-type gelatin, enzyme pretreatment was tried on flounder(Limanda aspera) skin for E-type gelatin. The optimal extraction conditions of the B-type gelatin were 9 folds of added water with material(w/w), 3 hrs of extraction time, 60℃ of extraction temperature and pH 5. The maximum amount of E-type gelatin was extracted at 60℃ for 3 hrs using water controlled to pH 6.0(material : water=1 : 9, w/w). The yields of the B- and E-type gelatin were 64.2% and 59.2%, respectively. The B-type was superior to the E-type in physical properties such as jelly strength, viscosity and electric conductivity. Molecular weight of B-type was so far larger than that of the E-type due to different pretreatment method. Hydrolysis ratio of the E-type was higher than that of the B-type because of its molecular weight. Results suggest that B-type product would be better than E-type as fish skin gelatin but E-type was desirable in hydrolyzate preparation.