gebhart/patrepeval huggingface dataset:
Side-Stream Enhanced Biological Phosphorus Removal (S2EBPR) Enables Effective Phosphorus Removal in a Pilot-scale Shortcut Nitrogen Removal System (2023)

To meet the growing interest in the development of innovative biological nutrient removal (BNR) alternatives for energy neutrality, resource recovery, and decarbonization, the adsorption/bio-oxidation (A/B) process has been widely studied for carbon capture and shortcut nitrogen (N) removal, while limited research has focused on incorporating enhanced biological phosphorus (P) removal (EBPR), mainly due to the differential carbon usage characteristics of functionally relevant microorganisms. Here, a full-scale pilot testing with an integrated system combining A-stage high-rate activated sludge (HRAS) with B-stage partial (de)nitrification/anammox and side-stream EBPR (HRAS-P(D)N/A-S2EBPR) was conducted treating real municipal wastewater. The results demonstrated that, despite the low influent carbon load, the B-stage P(D)N-S2EBPR system achieved effective and stable P removal performance, especially when the volatile fatty acid (VFA) load from A-stage was elevated. Sludge fermentation in both A-stage and B-stage promoted carbon redistribution and likely provided more competitive advantages for ammonium-oxidizing bacteria and polyphosphate accumulating organisms, leading to carbon-efficient shortcut N removal mainly through partial nitrification pathway and influent carbon-independent EBPR simultaneously. Exposure to high VFA levels was considered a potential selection factor for the suppression of nitrite-oxidizing bacteria in the system. The involvement of internal carbon-accumulating organisms would potentially play an important role in endogenous denitrification. This study provided new insights into the effects of incorporating side-stream EBPR into the A/B process on microbial ecology, metabolic activities, and system performance.
Precise Motion Control of Wafer Stages via Adaptive Neural Network and Fractional-Order Super-Twisting Algorithm (2020)

To obtain precise motion control of wafer stages, an adaptive neural network and fractional-order super-twisting control strategy is proposed. Based on sliding mode control (SMC), the proposed controller aims to address two challenges in SMC: 1) reducing the chattering phenomenon, and 2) attenuating the influence of model uncertainties and disturbances. For the first challenge, a fractional-order terminal sliding mode surface and a super-twisting algorithm are integrated into the SMC design. To attenuate uncertainties and disturbances, an add-on control structure based on the radial basis function (RBF) neural network is introduced. Stability analysis of the closed-loop control system is provided. Finally, experiments on a wafer stage testbed system are conducted, which proves that the proposed controller can robustly improve the tracking performance in the presence of uncertainties and disturbances compared to conventional and previous controllers.
Alpha 2-adrenergic stimulation promotes preadipocyte proliferation. Involvement of mitogen-activated protein kinases. (1994)

Primary cultures of rat preadipocytes were shown to express alpha 2- and beta-adrenoreceptors when maintained in serum-deprived medium. alpha 2-Adrenoreceptor stimulation led to an increase in cell number, whereas beta-adrenoreceptor stimulation was without effect. On 3T3-F442A clones stably transfected with the human alpha 2-C10 gene and expressing a physiologically related number of alpha 2-adrenoreceptors to overexpression, the proliferative effect of alpha 2-adrenoreceptor agonist UK14304 was proportional to the level of alpha 2-adrenoreceptor expressed in individual clones and required alpha-2 adrenoreceptor stimulation. Analysis of the signaling pathway linked to alpha 2-adrenoreceptor activation showed that the mitogenic effect was adenylyl cyclase- and protein kinase C-independent. It was pertussis toxin-sensitive, implying the involvement of pertussis toxin-sensitive G proteins. The activation of the mitogen-activated protein kinase pathway was increased after alpha 2-adrenoreceptor stimulation in both 3T3-F442 clones and rat preadipocytes and inhibited by pertussis toxin treatment. So, catecholamines are involved in the control of white preadipocyte proliferation through the alpha 2-adrenoreceptor activation, linked to the mitogen-activated protein kinase pathway.
Long-Range Auditory Functional Connectivity in Hearing Loss and Rehabilitation (2021)

<b><i>Background:</i></b> Patients with age-related sensorineural hearing loss (HL) may benefit from auditory input amplification by using hearing aids (HAs). However, the impact of both HL- and HA-based rehabilitation on central auditory functional connectivity (FC) is not clear. <b><i>Methodology:</i></b> Sixty-two HL (22 females, aged 64.4 ± 7.6 years, pure-tone average 50.9 ± 14.7 dB right ear, 50.7 ± 12.9 dB left ear) and 32 normal hearing (NH) subjects (22 females, aged 59.3 ± 7.3 years) were examined in a 3T magnetic resonance imaging (MRI) study. HL patients were analyzed cross-sectionally at baseline (vs. NH subjects) and longitudinally at 6-month follow-up. Between the 2 scans, 31/62 patients used the HA 9.5 ± 3.8 h a day. Arterial spin labeling and blood oxygen level-dependent resting-state functional MRI were performed to measure regional perfusion in the primary auditory cortex and, from here to the whole brain, seed-based FC was performed. Before each scan, HL patients underwent audiological and neurological assessments. <b><i>Results:</i></b> At baseline, the HL condition was associated with regional hypoperfusion in right Heschl's gyrus (seed) and negative seed-based FC (anticorrelation) in posterior brain regions. Long-range FC in the precuneus correlated negatively with pure-tone and speech reception average thresholds. At 6-month follow-up, HA usage was associated with seed-based FC increase in the right superior frontal gyrus (SFG) and seed-based FC reduction in the right middle temporal gyrus. Long-range FC changes in the SFG correlated positively with executive function improvements. <b><i>Conclusions:</i></b> These findings suggest that HA-based rehabilitation may not reverse HL-related neural effects and yet carry neurological benefits by retuning long-range FC of the auditory system. Impact statement Age-related sensorineural hearing loss (HL) affects 40% to 60% of the worldwide population and a common, viable rehabilitation strategy is to provide auditory input amplification through hearing aids (HAs). By targeting metabolically depressed, auditory cortical centers, our work reveals a possible neural link between peripheral and central vulnerability in HL patients in the form of aberrant, long-range, functional connectivity effects. Similarly, we unveil how wearing HAs for 6 months may induce neuroplastic changes that positively correlate with improved neuropsychological performances.
Relationship Between Central and Peripheral SMN Protein Increase Upon Treatment with RO7034067 (RG7916) (S46.007) (2018)

To assess tissue distribution and effect of RO7034067 (RG7916) on survival of motor neuron (SMN) protein expression in animal models of spinal muscular atrophy (SMA).
Supplementary Figures from HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress (2023)

&lt;p&gt;Figure S1- Piericidin A and HORMAD1 association identified by NPF screen; Figure S2- Piericidin A induces DNA damage in NSCLC lines; Figure S3- S2N and geneset overlaps for HORMAD1 high LUAD tumors.&lt;/p&gt;
Computational and experimental study of an oil jet in crossflow: coupling population balance model with multifluid large eddy simulation (2021)

Understanding the size of oil droplets released from a jet in crossflow is crucial for estimating the trajectory of hydrocarbons and the rates of oil biodegradation/dissolution in the water column. We present experimental results of an oil jet with a jet-to-crossflow velocity ratio of 9.3. The oil was released from a vertical pipe 25 mm in diameter with a Reynolds number of 25 000. We measured the size of oil droplets near the top and bottom boundaries of the plume using shadowgraph cameras and we also filmed the whole plume. In parallel, we developed a multifluid large eddy simulation model to simulate the plume and coupled it with our VDROP population balance model to compute the local droplet size. We accounted for the slip velocity of oil droplets in the momentum equation and in the volume fraction equation of oil through the local, mass-weighted average droplet rise velocity. The top and bottom boundaries of the plume were captured well in the simulation. Larger droplets shaped the upper boundary of the plume, and the mean droplet size increased with elevation across the plume, most likely due to the individual rise velocity of droplets. At the same elevation across the plume, the droplet size was smaller at the centre axis as compared with the side boundaries of the plume due to the formation of the counter-rotating vortex pair, which induced upward velocity at the centre axis and downward velocity near the sides of the plume.
Noise and gain in frequency mixers with NbN SIS junctions (1997)

We study noise and conversion gain in the SIS mixers with Nb/MgO/NbN junctions at the millimeter and submillimeter wavelengths in order to estimate the possibility to extent the low noise operation towards the theoretical limit of 4/spl Delta//h=2.4 THz. We present as preliminary result the lowest achieved receiver noise with NbN SIS junctions of 65 K with conversion gain of -6 dB at 162 GHz and 230 K receiver noise with conversion gain of -10 dB at 306 GHz. The junction area is 2 /spl mu/m/sup 2/ and Josephson critical current density is 1.4 KA/cm/sup 2/. The optimum R/sub N//spl omega/C of NbN junction for mixers is estimated as 600 GHz/V. In preliminary tests the junctions R/sub N//spl omega/C is 10-20 time superior to the optimum and a significant improvement of NbN SIS mixers may be expected. The noise sources in the NbN SIS junctions are studied and a possible mixer sensitivity improvement is discussed. The thermal properties of the SIS NbN are studied. The frequency limit of the low loss integrated tuning structure in NbN is estimated as at least as 1.5 THz.
Therapeutic Effect of a Novel Chimeric Molecule Targeting Both Somatostatin and Dopamine Receptors on Growth Hormone-Secreting Pituitary Adenomas (2020)

The novel chimeric molecule was effective in decreasing IGF-1 and GH levels and may serve as an effective therapeutic agent for acromegaly.
Is A Modified Supine Nephrolithotomy Better Than Prone Percutaneous Nephrolithotomy? (2022)

Background: Percutaneous nephrolithotomy [PCNL] is the gold standard surgical procedure for treating large, complex renal stones. The ultimate PCNL positioning is debatable. As a result, research on the influence of patient posture on PCNL outcomes is required.The aim of the work: This study aimed to compare the surgical outcome of PCNLs performed using modified supine positions [MSP] with the standard prone position [PP].Patients and Methods: This prospective, non-randomized study included 350 PCNL patients, 150 in the PP group and 200 in the MSP group. We included patients with urinary stones who came to the Urology Department, Al-Azhar University, Damietta, Egypt, for PCNL, during the period from January 2017 to December 2020.Results: The mean operative time of the studied patients was 120.8±32.6 and 91.7±35.4 min in PP and MSP groups, respectively [P=0.001]. The mean hospital stay was significantly [P=0.003] longer in the PP group [3.0±2.5 days] than in the MSP group [2.0±2.1 days]. Both groups have a comparable rate [MPS: 82% vs. PP 80%; P=0.856] in terms of stone-free rate. The mean heart rate was higher [p=0.002] in the PP group [96.8±12.6 bpm] than in the MSP group [72.6±11.9 bpm]. Regarding operative complications, the overall complication rate was higher in the PP [11.33%] than in the MSP group [6%]; however, there is no statistically significant difference [p=0.073].Conclusion: The current findings demonstrated that MSP had a shorter operative time and shorter hospital stays. Both groups showed a comparable stone-free rate and postoperative complications.
A Wireless Sensor for Monitoring Corrosion and Chloride (2008)

Abstract not Available.
The Microsoft HoloLens 2 Provides Accurate Measures of Gait, Turning, and Functional Mobility in Healthy Adults (2022)

Augmented-reality (AR) headsets, such as the Microsoft HoloLens 2 (HL2), have the potential to be the next generation of wearable technology as they provide interactive digital stimuli in the context of ecologically-valid daily activities while containing inertial measurement units (IMUs) to objectively quantify the movements of the user. A necessary precursor to the widespread utilization of the HL2 in the fields of movement science and rehabilitation is the rigorous validation of its capacity to generate biomechanical outcomes comparable to gold standard outcomes. This project sought to determine equivalency of kinematic outcomes characterizing lower-extremity function derived from the HL2 and three-dimensional (3D) motion capture systems (MoCap). Sixty-six healthy adults completed two lower-extremity tasks while kinematic data were collected from the HL2 and MoCap: (1) continuous walking and (2) timed up-and-go (TUG). For all the continuous walking metrics (cumulative distance, time, number of steps, step and stride length, and velocity), equivalence testing indicated that the HL2 and MoCap were statistically equivalent (error ≤ 5%). The TUG metrics, including turn duration and turn velocity, were also statistically equivalent between the two systems. The accurate quantification of gait and turning using a wearable such as the HL2 provides initial evidence for its use as a platform for the development and delivery of gait and mobility assessments, including the in-person and remote delivery of highly salient digital movement assessments and rehabilitation protocols.
Time-Asymmetric and Subcarrier-Specific Pulse Shaping in OFDM-Based Waveforms (2014)

In orthogonal frequency-division multiplexing (OFDM) systems, suppressing the out-of-band (OOB) emission with pulse shaping comes with a price. The expense emerges in designing the transition between consecutive symbols. The price can be either the reduction of spectral efficiency (SE) with symbol extension for better transition or the introduction of intersymbol and intercarrier interference (ISI and ICI) due to reduced cyclic prefix (CP) size. In this paper, we propose a time-asymmetric and per-subcarrier (per-SC) pulse-shaping method to minimize the introduced interference without sacrificing SE and OOB performances. Although time-asymmetric pulse reduces the interference due to shortened CP by exploiting the asymmetry in channel delay profile, it causes spectral growth. Thus, the time asymmetry of the pulse-shaping function is gradually increased for the inner SCs that have wider spectral room to the OOB region. A generalized Kaiser window with adjustable time asymmetry is introduced to the provided framework. Theoretical and simulation results showed that the proposed technique achieves superior BER performance while achieving the same level of OOB suppression of pulse shaping and SE of plain OFDM.
Task Migration In Hypercube Multiprocessors (2005)

Allocation and deallocation of subcubes usually result in a fragmented hypercube where even if a sufficient number of hypercube nodes are available, they do not form a subeube large enough to execute an incoming task. As the fragmentation in conventional memory allocation can be handled by memory compaction, the fragmentation problem in a hypercube can be solved by task migration, i.e., relocating tasks within the hypercubc to remove the fragmentation. The procedure for task migration closely depends on the subcube allocation strategy used, since active tasks must be relocated in such a way that the availability of subcubcs can be detected by that allocation strategy. In this paper, we develop a task migration strategy for the sub cube allocation policy based on the binary reflected Gray code. A goal configuration (of destination subeubes) without fragmentation is determined first. Then, the node-mapping between the source and destination subcubes is derived. Finally, a routing procedure to achieve shortest deadlock-free paths for relocating tasks is developed.
Improving the granularity of access control in Windows NT (2001)

This paper presents the access control mechanisms in Windows 2000 that enable fine-grained protection and centralized management. These mechanisms were added during the transition from Windows NT 4.0 to support the Active Directory, a new feature in Windows 2000. We first extended entries in access control lists to allow rights to apply to just a portion of an object. The second extension allows centralized management of object hierarchies by specifying more precisely how access control lists are inherited. The final extension allows users to limit the rights of executing programs by restricting the set of objects they may access. These changes have the combined effect of allowing centralized management of access control while precisely specifying which accesses are granted to which programs.
Safety, tolerability and immunogenicity of V934/V935 hTERT vaccination in cancer patients with selected solid tumors: a phase I study (2020)

Our results suggest the safety and feasibility of V934/V935 hTERT vaccination in cancer patients with solid tumors Trial Registration Name of the registry: ClinicalTrial.gov Trial registration number: NCT00753415 Date of registration: 16 September 2008 Retrospectively registered URL of trial registry record: https://clinicaltrials.gov/ct2/results?cond=&term=NCT00753415&cntry=&state=&city=&dist=.
Novel (110) Double-Layered Guanidinium-Lead Iodide Perovskite Material: Crystal Structure, Electronic Structure, and Broad Luminescence (2021)

In this work, a new crystalline structure of two-dimensional (2D) Ruddlesden–Popper guanidinium lead iodide [C(NH₂)₃]₂PbI₄ with a particular organic cation orientation is proposed. Density functional theory calculations indicate that this structure of [C(NH₂)₃]₂PbI₄ is more energetically stable than the reported structure belonging to the Pmna space group. The crystalline and electronic structures of the new [C(NH₂)₃]₂PbI₄ are calculated by various functionals with and without spin–orbit coupling (SOC). Powder X-ray diffraction on [C(NH₂)₃]₂PbI₄ powder and thin film materials confirm the Pmna structure. A weak, but sharp, free excitonic peak combined with a strong broadened emission feature due to the corrugated 2D layers is observed by the absorption measurement of the thin film samples and by photoluminescence spectra. The present article shows that the complementarity between experiment and simulation improves the structural and optical understanding of this new 2D [C(NH₂)₃]₂PbI₄ material. Furthermore, this material is crucial to the study of both free excitonic effects and strong exciton-phonon coupling in a double-layer confinement. In addition, our results indicate that the relativistic effect of electrons with nonzero angular momentum via SOC in this compound plays a central role in its electronic properties.
Fiber-based Frequency Modulated LiDAR With MEMS Scanning Capability for Long-range Sensing in Automotive Applications (2021)

Safe operation of driver assistance systems, especially at higher speeds, remains a challenge. For this automotive application, we propose a long-range coherent LiDAR system concept with two-dimensional micro electro-mechanical system (MEMS) scanning and sparse sensing capability. We address system design challenges for the transmitter, the fiber-based optics and coherent receiver, and the impact on MEMS mirror design. Furthermore, we compare compressed sensing and deep learning techniques to implement sparse sensing and we provide preliminary results of the systems performance with a simplified setup.
Table S1 from Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma (2023)

&lt;p&gt;Supplementary Table 1 | Gene set for kinome sequencing.&lt;/p&gt;
Molecular pathogenesis of Spondylocheirodysplastic Ehlers‐Danlos syndrome caused by mutant ZIP13 proteins (2014)

The zinc transporter protein ZIP13 plays critical roles in bone, tooth, and connective tissue development, and its dysfunction is responsible for the spondylocheirodysplastic form of Ehlers-Danlos syndrome (SCD-EDS, OMIM 612350). Here, we report the molecular pathogenic mechanism of SCD-EDS caused by two different mutant ZIP13 proteins found in human patients: ZIP13(G64D), in which Gly at amino acid position 64 is replaced by Asp, and ZIP13(ΔFLA), which contains a deletion of Phe-Leu-Ala. We demonstrated that both the ZIP13(G64D) and ZIP13(ΔFLA) protein levels are decreased by degradation via the valosin-containing protein (VCP)-linked ubiquitin proteasome pathway. The inhibition of degradation pathways rescued the protein expression levels, resulting in improved intracellular Zn homeostasis. Our findings uncover the pathogenic mechanisms elicited by mutant ZIP13 proteins. Further elucidation of these degradation processes may lead to novel therapeutic targets for SCD-EDS.
A Self-Energized Sensor for Wireless Injection Mold Cavity Pressure Measurement: Design and Evaluation (2004)

This paper presents the modeling, design, and experimental validation of a self-energized sensor system for pressure measurement in the injection mold cavity using ultrasound as the information carrier. The sensor extracts energy from the polymer melt pressure and discretizes the pressure information into ultrasonic pulses for wireless transmission through the mold to a remote receiver. Analytical and numerical models are presented for three constituent components of the sensor: the energy converter, the threshold modulator, and the signal transmitter. Quantitative results were obtained to guide the parametric design of each constituent component. Simulations and experimental studies have validated the functionality of each individual component, as well as the sensor as an integrated unit. In addition to the injection mold pressure measurement, the sensing technique developed is applicable in a broad range of process monitoring applications where high pressure fluctuations occur.
Director grating and two-beam energy exchange in a hybrid photorefractive cholesteric cell with a helicoidal polymer network (2020)

We develop a theory describing two-beam energy exchange in a cholesteric liquid crystal (CLC) stabilized in the planar state by a helicoidal polymer network. The CLC layer is placed between photorefractive and non-photorefractive substrates and illuminated by two intersecting coherent light beams. An interference pattern created by the incident beams induces a spatially periodic space-charge electric field in the photorefractive substrate. The field penetrates into the adjacent CLC layer and interacts with the charges trapped on the polymer fibrils forcing the fibrils to move along the helicoidal axis. At new positions, the fibrils reorient the CLC director and, therefore, induce a director grating. The light beams propagating across the cell couple within the grating. We calculate the energy exchange between the coupled beams and the gain of the weak light beam. We analyze the dependence of the gain coefficient on the parameters of the polymer network and the CLC and show that it can reach values greater than those obtained in typical solid photorefractive crystals.