gebhart/patrepeval huggingface dataset:
Feasibility and safety of non-invasive ultrasound therapy (NIUT) on an porcine aortic valve (2020)

Calcific aortic stenosis (CAS) is associated with advanced age and comorbidities, therefore a non-invasive therapy for it would be beneficial. We previously demonstrated that ultrasound therapy improved calcified bioprosthetic valve function in an open chest model. For translational applications, we tested non-invasive ultrasound therapy (NIUT) transthoracically on swine aortic valves and investigated the need for antithrombotic treatment as a follow-up. Primary objective: feasibility and safety of NIUT. Secondary objectives: occurrence, severity and evolution of side effects during therapy and at 1 month follow-up. The device (Valvosoft, Cardiawave) consisted of an electronically steered multi-element transducer and a 2D echocardiographic probe. Three groups of swine received treatment on aortic valves: NIUT (group 1; n = 10); NIUT and 1 month antithrombotic treatment (group 2; n = 5); sham group (group 3; n = 4). Feasibility was successfully reached in all treated swine (n = 15) and no life-threatening arrhythmia were detected. Non-sustained ventricular tachycardia occurred during the procedure in seven swine. Decrease or interruption of NIUT ended arrhythmia. Histopathology revealed no valve or surrounding tissue damage and echocardiography revealed no valvular dysfunction. Only one animal had side effects [right ventricle (RV) dilatation], but the RV normalized after therapy cessation with no sequelae at follow-up. No disturbance in biological markers nor valve thrombosis were observed at follow-up. Antithrombotic treatment did not demonstrate any advantage. Survival at 30 d was 100%. We demonstrated, in vivo, the feasibility and safety of transthoracic NIUT on aortic valves in a swine model without serious adverse events. We expect this first-time transthoracic delivery of NIUT to pave the way towards a new non-invasive approach to valve softening in human CAS to restore valve function.
Correlation of Molecular Structure with Photophysical Properties and Device Performances of Thermally Activated Delayed Fluorescent Emitters (2016)

Thermally activated delayed fluorescent (TADF) emitters having bicarbazole as a donor unit based on a twin emitting core design were developed by substituting the bicarbazole donor with a diphenyltriazine acceptor. Three bicarbazole derived delayed fluorescent emitters linked via 2,3′-, 3,3′-, and 3,4′-positions of carbazole were synthesized and investigated as blue dopants of the TADF devices. A twin emitting core based TADF emitter derived from a 3,3′-bicarbazole donor exhibited a high quantum efficiency of 25.0% in the greenish blue TADF device. A 3,3′-linkage induced red shift of the emission wavelength, a small singlet–triplet energy gap, and a high quantum efficiency were revealed.
Modelling selection response in plant-breeding programs using crop models as mechanistic gene-to-phenotype (CGM-G2P) multi-trait link functions (2020)

Abstract Plant-breeding programs are designed and operated over multiple cycles to systematically change the genetic makeup of plants to achieve improved trait performance for a Target Population of Environments (TPE). Within each cycle, selection applied to the standing genetic variation within a structured reference population of genotypes (RPG) is the primary mechanism by which breeding programs make the desired genetic changes. Selection operates to change the frequencies of the alleles of the genes controlling trait variation within the RPG. The structure of the RPG and the TPE has important implications for the design of optimal breeding strategies. The breeder’s equation, together with the quantitative genetic theory behind the equation, informs many of the principles for design of breeding programs. The breeder’s equation can take many forms depending on the details of the breeding strategy. Through the genetic changes achieved by selection, the cultivated varieties of crops (cultivars) are improved for use in agriculture. From a breeding perspective, selection for specific trait combinations requires a quantitative link between the effects of the alleles of the genes impacted by selection and the trait phenotypes of plants and their breeding value. This gene-to-phenotype link function provides the G2P map for one to many traits. For complex traits controlled by many genes, the infinitesimal model for trait genetic variation is the dominant G2P model of quantitative genetics. Here we consider motivations and potential benefits of using the hierarchical structure of crop models as CGM-G2P trait link functions in combination with the infinitesimal model for the design and optimization of selection in breeding programs.
Beta-Band Oscillations Represent Auditory Beat and Its Metrical Hierarchy in Perception and Imagery (2015)

With magnetoencephalography, we examined β-band oscillatory activities around 20 Hz while participants listened to metronome beats and imagined musical meters such as a march and waltz. We demonstrated that β-band event-related desynchronization in the auditory cortex differentiates between beat positions, specifically between downbeats and the following beat. This is the first demonstration of β-band oscillations related to hierarchical and internalized timing information. Moreover, the meter representation in the β oscillations was widespread across the brain, including sensorimotor and premotor cortices, parietal lobe, and cerebellum. The results extend current understanding of the role of β oscillations in neural processing of predictive timing.
Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease (2021)

Abstract The COVID-19 pandemic has led to an urgent need for the identification of new antiviral drug therapies that can be rapidly deployed to treat patients with this disease. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2. We developed a computational approach to identify new antiviral drug targets and repurpose clinically-relevant drug compounds for the treatment of COVID-19. Our approach is based on graph convolutional networks (GCN) and involves multiscale host-virus interactome analysis coupled to off-target drug predictions. Cellbased experimental assessment reveals several clinically-relevant repurposing drug candidates predicted by the in silico analyses to have antiviral activity against human coronavirus infection. In particular, we identify the MET inhibitor capmatinib as having potent and broad antiviral activity against several coronaviruses in a MET-independent manner, as well as novel roles for host cell proteins such as IRAK1/4 in supporting human coronavirus infection, which can inform further drug discovery studies.
A cost-effective multistage interconnection network with network overlapping and memory interleaving (1985)

A cost-effective design is proposed for circuit-switching multistage interconnection networks (CSMINs). Increase of the network bandwidth and reduction of the network size (and thus low costs) are accomplished by network overlapping and memory interleaving (NOMI), instead of by increasing the number of switches or adding buffers. NOMI and its control principle are described on the basis of the structure and interconnection functions of CSMINs. Detailed accounts of both the network design and the drastic reduction in hardware costs are given. The impact of NOMI on system performance is also analyzed.
Ceramic strain gages for propulsion health monitoring (2002)

A robust ceramic strain gage has been developed for propulsion health monitoring which is capable of measuring both static and dynamic strains at temperatures up to 1400/spl deg/C. These thin film sensors are ideally suited for in-situ strain measurement in harsh environments such as those encountered in the hot sections of gas turbine engines. The sensors are non-intrusive and robust enough to withstand the high "g" loading associated with rotating engine components. Since gage thickness is considerably less than the boundary layer thickness, these sensors do not adversely affect the gas flow path through the engine. Results of recent laboratory tests have shown that these strain gages can meet many of the current demands of high performance propulsion engines. Specifically, static strain tests have been performed at temperatures as high as 1400/spl deg/C, which have resulted in a relatively large and reproducible piezoresistive response. In addition, high frequency dynamic strain tests were performed at temperatures up to 500/spl deg/C and at frequencies up to 2000 Hz to simulate conditions that would be encountered during high cycle fatigue. The results indicated that not only did these sensors survive severe testing conditions, including an applied strain of /spl plusmn/500 /spl mu//spl epsiv/, but that they were sensitive enough to isolate possible causes of high cycle fatigue. The results of both the static and dynamic strain measurements at elevated temperature using these ceramic strain gages are presented and the prospects of using these strain gages for structural health monitoring are discussed.
Experimental Study of a Relativistic Resonant Traveling-Wave Tube With Selective Feedback Provided by Bragg Reflectors (2010)

The realization of single-mode generation in a microwave oscillator is considered for a relativistic resonant traveling-wave tube (RTWT) with spiral Bragg reflectors at the ends of a multimode electrodynamic system. An oversized azimuthally symmetric slow-wave structure was chosen so that only two field structures are synchronous with a 1-MeV electron beam. Experiments using different means that allow us to separate these field structures are described. As a result, two radiation patterns were observed separately, which are a narrow Gaussian-like wave beam with a power of up to 1.5 GW and an efficiency of about 20% in 40-ns pulses and radiation corresponding to the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">01</sub> mode with four times weaker power. The dependences of RTWT operation on the parameters of the electron beam, the length of interaction space, reflection coefficients, and the amplitude of guide axial magnetic field are investigated in detail.
Novel gene encoding a unique luciferase from the fireworm Odontsyllis undecimdonta (2018)

Luciferases identified or engineered so far emit violet, blue, blue-green, green, yellow, red or near infra-red light. The unique and beautiful bluish-green bioluminescence of fireworms Odontosyllis spp. has attracted particular interest, however, their molecular basis is totally unknown partly due to the difficulty of animal collection. Here we report a novel type of luciferase gene from the Japanese fireworm O. undecimdonta. The major SDS-PAGE band of the luminous mucus showed luciferase activity. A highly sensitive mass spectrometry analysis in combination with RNA sequencing technique revealed that this band was product of a single gene with no homology to any other sequences in public databases. The recombinant protein of this putative luciferase gene expressed in mammalian cells produced the same unique bluish-green emission peak as the fireworm crude extract, indicating that this novel gene is the genuine fireworm luciferase with an evolutionary different origin from other luciferases previously described. Our findings extend the repertoire of luciferin/luciferase system to previously unavailable wavelength range.
Refocusing SoTL – Myopia, Context Lenses and Ecological Systems Theory (2023)

Submitted: 15 July 2022 Accepted: 21 September 2022 Published online: 4 April, TAPS 2023, 8(2), 80-82 https://doi.org/10.29060/TAPS.2023-8-2/PV2842 Kevin Tan1,2, Yang Yann Foo2 & Nigel Choon Kiat Tan1,2 1Office of Neurological Education, Department of Neurology, National Neuroscience Institute, Singapore; 2Duke-NUS Medical School, Singapore A program director of a one-year-old Singapore surgical residency programme reads a publication […]
Raman cross talk of soliton collision in a lossless fiber (1989)

The cross talk induced by soliton collision with a Raman effect in a lossless fiber is discussed. There are frequency-shift enhancements for the two colliding solitons in addition to the energy transfer. The maximum rate-distance product limited by energy depletion is obtained for the soliton-based wavelength-division-multiplexing system.
FOPA with Flat 21-dB Gain and NF less than 4-dB using Alternately Concatenated Pump-Phase Shifters and HNLFs (2013)

We demonstrate a single pumped fiber optical parametric amplifier using alternately concatenated highly nonlinear fibers and pump phase shifters for quasi phase matching. Gain bandwidth with 1 dB flatness is 25 nm. Noise figure is less than 4 dB.
Conantokin-Br fromConus brettinghamiand Selectivity Determinants for the NR2D Subunit of the NMDA Receptor (2009)

Conantokins are venom peptides from marine cone snails that are NMDA receptor antagonists. Here, we report the characterization of a 24 AA conantokin from Conus brettinghami Coomans , H. E. , Moolenbeek , R. G. and Wils , E. ( 1982 ) Basteria 46 ( 1/4 ), 3 - 67 , conantokin-Br (con-Br), the first conantokin that does not have the conserved glutamate residue at position 2. Molecular modeling studies suggest that con-Br has a helical structure between residues 2-13. In contrast to other characterized conantokins, con-Br has a high potency for NMDA receptors with NR2D subunits. To identify determinants for NR2D potency, we synthesized chimeras of con-Br and conantokin-R (con-R); the latter has a approximately 30-fold lower potency for the NR2D subtype. The characterization of two reciprocal chimeras (con-Br/R and con-R/Br), comprising the first 9-10 N-terminal AAs of each conantokin followed by the corresponding C-terminal AAs of the other conantokin demonstrates that determinants for NR2D selectivity are at the N-terminal region. Additional analogues comprising 1-3 amino acid substitutions from each peptide into the homologous region of the other led to the identification of a key determinant; a Tyr residue in position 5 increases potency for NR2D, while Val at this locus causes a decrease. The systematic definition of key determinants in the conantokin peptides for NMDA receptor subtype selectivity is an essential component in the development of conantokin peptides that are highly selective for each specific NMDA receptor subtype.
EXPERIMENTAL ANALYSIS AND MICROMECHANICAL MODELING OF THE BEHAVIOUR OF WIREDRAWN STEEL FIBRES, ANCHORED IN A CEMENTITIOUS MATRIX.. (1993)

Available at INIST (FR), Document Supply Service, under shelf-number : 22859, issue : a.1993 n.12 / INIST-CNRS - Institut de l'Information Scientifique et Technique
Tex2Shape: Detailed Full Human Body Geometry From a Single Image (2019)

We present a simple yet effective method to infer detailed full human body shape from only a single photograph. Our model can infer full-body shape including face, hair, and clothing including wrinkles at interactive frame-rates. Results feature details even on parts that are occluded in the input image. Our main idea is to turn shape regression into an aligned image-to-image translation problem. The input to our method is a partial texture map of the visible region obtained from off-the-shelf methods. From a partial texture, we estimate detailed normal and vector displacement maps, which can be applied to a low-resolution smooth body model to add detail and clothing. Despite being trained purely with synthetic data, our model generalizes well to real-world photographs. Numerous results demonstrate the versatility and robustness of our method.
A Comparison between Network-Controlled Repeaters and Reconfigurable Intelligent Surfaces (2022)

Network-controlled repeater (NCR) has been recently considered as a study-item in 3GPP Release 18, and the discussions are continuing in a work-item. In this paper, we introduce the concept of NCRs, as a possible low-complexity device to support for network densification and compare the performance of the NCRs with those achieved by reconfigurable intelligent surfaces (RISs). The results are presented for the cases with different beamforming methods and hardware impairment models of the RIS. Moreover, we introduce the objectives of the 3GPP Release 18 NCR work-item and study the effect of different parameters on the performance of NCR-assisted networks. As we show, with a proper deployment, the presence of NCRs/RISs can improve the network performance considerably.
Impact of facility type, insurance status, and income on use of single agent chemotherapy (SACT) for advanced hepatocellular carcinoma (AHCC): Analysis of National Cancer Database (NCDB). (2020)

504 Background: This study analyzes the pattern of use of SACT in the treatment and survival of AHCC before and after sorafenib was FDA approved in late 2007. Methods: Adult patients diagnosed with HCC and treated with only chemotherapy (CT) from 2004 – 2014 were identified in NCDB database. Patients were analyzed during 3 time frames: 2004–2006 (pre-sorafenib (PS), 2007–2011 (early sorafenib (ES) and 2012–2014 (late sorafenib (LS)). Cox proportional hazards models and Kaplan-Meier method were used for analyses. Results: The NCDB contained 31,107 patients with HCC diagnosed from 2004–2014 and treated with CT alone. Patients were generally men (77.3%), &gt;50 years of age (92.5%), and with a variety of T-stages - T1 (31.0%), T2 (23.9%), T3 (28.3%), and T4 (16.9%). The use of SACT was only 6.2% in the PS period, increased to 15.5% in the ES period, and to 22.3% in the LS period (p&lt;0.0001). During this later period, the highest proportion of SACT is among academic and integrated network facilities (23.4%) as compared to community facilities (16.4%, p&lt;0.0001). The MS of patients with AHCC treated only with CT has improved significantly over the study periods from 10 months (m) (95% CI: 9.5-10.6) to 12.5m (12.0-12.9) to 16m (15.6-16.4, p&lt; 0.001). Significant differences in MS were found between facility types in all time frames (Table). Multivariate analysis indicates worse outcomes for patients treated at community cancer programs (HR 1.66, 1.53-1.79) as compared to academic programs as well as for no insurance (HR 1.13, 1.05-1.22) and estimated household income of &lt;$63,000 (HR 1.09, 1.05-1.13). Conclusions: Despite an overall improvement in survival for AHCC patients treated with only CT, significant differences in the utilization of SACT and survival exist by facility type, insurance status, and income. [Table: see text]
Rhythm in the Premature Neonate Brain: Very Early Processing of Auditory Beat and Meter (2023)

The ability to extract rhythmic structure is important for the development of language, music, and social communication. Although previous studies show infants' brains entrain to the periodicities of auditory rhythms and even different metrical interpretations (e.g., groups of two vs three beats) of ambiguous rhythms, whether the premature brain tracks beat and meter frequencies has not been explored previously. We used high-resolution electroencephalography while premature infants (<i>n</i> = 19, 5 male; mean age, 32 ± 2.59 weeks gestational age) heard two auditory rhythms in the incubators. We observed selective enhancement of the neural response at both beat- and meter-related frequencies. Further, neural oscillations at the beat and duple (groups of 2) meter were phase aligned with the envelope of the auditory rhythmic stimuli. Comparing the relative power at beat and meter frequencies across stimuli and frequency revealed evidence for selective enhancement of duple meter. This suggests that even at this early stage of development, neural mechanisms for processing auditory rhythms beyond simple sensory coding are present. Our results add to a few previous neuroimaging studies demonstrating discriminative auditory abilities of premature neural networks. Specifically, our results demonstrate the early capacities of the immature neural circuits and networks to code both simple beat and beat grouping (i.e., hierarchical meter) regularities of auditory sequences. Considering the importance of rhythm processing for acquiring language and music, our findings indicate that even before birth, the premature brain is already learning this important aspect of the auditory world in a sophisticated and abstract way.<b>SIGNIFICANCE STATEMENT</b> Processing auditory rhythm is of great neurodevelopmental importance. In an electroencephalography experiment in premature newborns, we found converging evidence that when presented with auditory rhythms, the premature brain encodes multiple periodicities corresponding to beat and beat grouping (meter) frequencies, and even selectively enhances the neural response to meter compared with beat, as in human adults. We also found that the phase of low-frequency neural oscillations aligns to the envelope of the auditory rhythms and that this phenomenon becomes less precise at lower frequencies. These findings demonstrate the initial capacities of the developing brain to code auditory rhythm and the importance of special care to the auditory environment of this vulnerable population during a highly dynamic period of neural development.
Use of Expectation Disconfirmation Theory to Test Patient Satisfaction with Asynchronous Telemedicine for Diabetic Retinopathy Detection (2018)

The EDT model is a viable framework to study patient satisfaction of telemedicine services. While previous feasibility studies have shown that telemedicine for diabetic retinopathy screenings yields diagnostic efficacy, this study applies a theoretical framework to demonstrate the viability of telemedicine for diabetic retinopathy screenings in rural areas.
Dynamic Bandwidth Allocation and Edge Caching Optimization for Nonlinear Content Delivery through Flexible Multibeam Satellites (2022)

The next generation multibeam satellites open up a new way to design satellite communication channels with the full flexibility in bandwidth, transmit power and beam coverage management. In this paper, we exploit the flexible multibeam satellite capabilities and the geographical distribution of users to improve the performance of satellite-assisted edge caching systems. Our aim is to jointly optimize the bandwidth allocation in multibeam and caching decisions at the edge nodes to address two important problems: i) cache feeding time minimization and ii) cache hits maximization. To tackle the non-convexity of the joint optimization problem, we transform the original problem into a difference-of-convex (DC) form, which is then solved by the proposed iterative algorithm whose convergence to at least a local optimum is theoretically guaranteed. Furthermore, the effectiveness of the proposed design is evaluated under the realistic beams coverage of the satellite SES-14 and Movielens data set. Numerical results show that our proposed joint design can reduce the caching feeding time by 50\% and increase the cache hit ratio (CHR) by 10\% to 20\% compared to existing solutions. Furthermore, we examine the impact of multispot beam and multicarrier wide-beam on the joint design and discuss potential research directions.
The Design and Fabrication of Poly(dimethylsiloxane) Single Mode Rib Waveguides for Lab-on-a-Chip Applications (2009)

This paper reports on the design and fabrication of Poly(dimethylsiloxane) (PDMS) single mode rib waveguide. PDMS was chosen as the base material for both the core and cladding of the waveguide. Such a PDMS waveguide allows an easy integration with microoptical components for lab-on-a-chip systems fabricated by soft lithography fabrication methods. The modification of the PDMS refractive index was achieved by diluting the base material with hexane. The fabricated PDMS rib waveguides were characterized for mode profile characteristics and the results confirmed the excitation of the waveguide's fundamental mode. The propagation loss was characterized at a wavelength of 635 nm and found to be 0.48 dB/cm. Such a low loss waveguide is useful as basic building block for complex microphonotnics device.