gebhart/patrepeval huggingface dataset:
Inside Cover Picture: Plasma Process. Polym. 5/2020 (2020)

Inside Front Cover: Silicon nanoparticles produced in a microwave-assisted plasma reactor are subjected to in-line functionalization in the plasma after-glow. Various coating precursors including TEOS, HMDSO and OMCTS were tested for their suitability. TEOS emerged to be the optimum choice in terms of formation of thin layers of pure SiO2 around the silicon core. The photograph shows the plasma zone with the beam of luminescing silicon nanoparticles. The image is taken by Jan Menser. Further details can be found in the article by Malini Dasgupta, Paolo Fortugno, Hartmut Wiggers. (e1900245).
Spontaneous Posterior Fossa Subdural Hematoma as a Complication of Anticoagulation (1984)

We report a patient in whom a spontaneous subdural hematoma developed in the posterior fossa during anticoagulation therapy for mitral valve disease. This rare complication of anticoagulation has been reported in only three other patients.
Critical behavior of the ferromagnetic perovskites RTiO3(R=Dy, Ho, Er, Tm, Yb) by magnetocaloric measurements (2013)

Ferromagnetism in perovskites RTiO${}_{3}$ can be induced by a steric effect. The way in which the subtle local structural change can induce three-dimensional (3D) ferromagnetic coupling through Ti-O-Ti superexchange interactions remains controversial. A critical behavior study for the ferromagnetic phase has been made so far only on YTiO${}_{3}$ because the magnetization measurements are plagued by the contribution from the magnetic rare earth. Here we report critical exponents for most ferromagnetic members in the RTiO${}_{3}$ family by measuring the magnetocaloric effect and applying the corresponding scaling laws. Our results indicate that the ferromagnetic coupling in the RTiO${}_{3}$ can be well described by the 3D Heisenberg model.
Distributed cognitive coexistence of 802.15.4 with 802.11 (2006)

Thanks to recent advances in wireless technology, a broad range of standards are currently emerging. Interoperability and coexistence between these heterogeneous networks are becoming key issues, which require new adaptation strategies to avoid harmful interference. In this paper, we focus on the coexistence of 802.11 Wireless LAN and 802.15.4 sensor networks in the ISM band. Those networks have very different transmission characteristics that result in asymmetric interference patterns. We propose distributed adaptation strategies for 802.15.4 nodes, to minimize the impact of the 802.11 interference. This interference varies in time, frequency and space and the sensor nodes adapt by changing their frequency channel selection over time. Different distributed techniques are proposed, based on scanning (with increasing power cost) on the one hand, and based on increased cognition through learning on the other hand. These techniques are evaluated both for performance and energy cost. We show that it is possible to achieve distributed frequency allocation approaches that result only in an increase of 20% of the delay performance compared to ideal frequency allocation. Moreover, it is shown that a factor of two in energy consumption can be saved by adding learning to the system
Urine and fecal microbiota in a canine model of bladder cancer and comparison of canine and human urine microbiota (2022)

Urothelial carcinoma (UC) is the tenth most diagnosed cancer in humans worldwide. Dogs are a robust model for invasive UC as tumor development and progression is similar in humans and dogs. Recent studies in humans have revealed alterations in urine microbiota in individuals with UC; however, microbial alterations in dogs with UC have not been evaluated. The objective of this pilot study was to compare the urine and fecal microbiota of dogs with UC and matched healthy controls. DNA was extracted from urine and fecal samples followed by 16S rRNA sequencing and analyses using QIIME2 and R. Dogs with UC had significantly decreased microbial diversity (Kruskal–Wallis; Shannon, p = 0.048) and altered microbial composition (PERMANOVA: Unweighted UniFrac, p = 0.011) in urine, but not fecal samples. The relative abundance of Fusobacterium was also increased, although not significantly, in urine and fecal samples of dogs with UC. A comparison of canine and human urine microbiota further revealed similarities in dominant microbial taxa across both host species. This study supports the value of dogs as a model for studies on bladder cancer and urine microbiota, and it provides a foundation for future work exploring host-microbe dynamics in UC carcinogenesis, prognosis, and treatment.
Galactosylceramidase deficiency and pathological abnormalities in cerebral white matter of Krabbe disease (2022)

Krabbe Disease (KD) is an autosomal recessive disorder that results from loss-of-function mutations in the GALC gene, which encodes lysosomal enzyme galactosylceramidase (GALC). Functional deficiency of GALC is toxic to myelin-producing cells, which leads to progressive demyelination in both the central and peripheral nervous systems. It is hypothesized that accumulation of psychosine, which can only be degraded by GALC, is a primary initiator of pathologic cascades. Despite the central role of GALC in KD pathomechanism, investigations of GALC deficiency at a protein level are largely absent, due in part, to the lack of sensitive antibodies in the field. Leveraging two custom antibodies that can detect GALC at endogenous levels, we demonstrated that GALC protein is predominantly localized to oligodendrocytes in cerebral white matter of an infant brain, consistent with its functional role in myelination. Mature GALC could also be quantitatively detected as a 26 kDa band by western blotting and correlated to enzyme activity in brain tissues. The p.Ile562Thr polymorphic variant, which is over-represented in the KD population, was associated with reduced mature GALC protein and activity. In three infantile KD cases, homozygous null mutations in GALC lead to deficiency in total GALC protein and activity. Interestingly, although GALC activity was absent, normal levels of total GALC protein were detected by a sandwich ELISA using our custom antibodies in a later-onset KD brain, which suggests that the assay has the potential to differentiate infantile- and later-onset KD cases. Among the infantile KD cases, we quantified a 5-fold increase in psychosine levels, and observed increased levels of acid ceramidase, a key enzyme for psychosine production, and hyperglycosylated lysosomal-associated membrane protein 1, a marker for lysosomal activation, in periventricular white matter, a major pathological brain region, when compared with age-matched normal controls. While near complete demyelination was observed in these cases, we quantified that an early-infantile case (age of death at 10 months) had about 3-fold increases in both globoid cells, a pathological hallmark for KD, and CD8-positive T lymphocytes, a pathological marker for multiple sclerosis, in the white matter when compared with a slower progressing infantile case (age of death at 21 months), which suggests a positive correlation between clinical severity and neuropathology. Taken together, our findings have advanced the understanding of GALC protein biology in the context of normal and KD brain white matter. We also revealed new neuropathological changes that may provide insights to understand KD pathogenesis.
Highly uniform heteroepitaxy of cobalt silicide by using Co-Ti alloy for sub-quarter micron devices (2002)

A new technology of cobalt SALICIDE (Self-ALIgned siliCIDE) process using cobalt-titanium alloy has been developed for sub-quarter micron devices. Extremely flat and epitaxial CoSi/sub 2/ films are successfully grown on a (100) Si substrate. Improved SALICIDE process is not influenced by native oxide on a Si surface. This technology will be very useful for realizing deep sub-quarter micron devices.
Detection of microRNAs in patients with sepsis (2015)

To externally validate the diagnostic and prognostic value of three previously identified microRNAs in emergency department patients with sepsis. Patients meeting consensus criteria for sepsis and septic shock were compared to controls. Three microRNAs (miR-150, miR-146a, and miR-223) were measured using real-time quantitative PCR, and levels of miRNAs were compared among the three cohorts. The association between miRNAs and both inflammatory markers and Sequential Organ Failure Assessment (SOFA) score were compared. To assess the prognostic value of each miRNA, unadjusted and adjusted logistic regression models were constructed using in-hospital mortality as the dependent variable. Ninety-three patients were enrolled; 24 controls, 29 with sepsis, and 40 with septic shock. We found no difference in serum plasma miR-146a or miR-223 between cohorts, and found no association among these microRNAs and either inflammatory markers or SOFA score. miR-150 demonstrated a significant correlation with SOFA score (P= 0.31, P=0.01) and IL-10 (P=0.37, P=0.001), but no IL-6 or TNF-α (P=0.046, P=0.59). Logistic regression demonstrated miR-150 to be independently associated with mortality, even after adjusting for SOFA score (P=0.003) or initial lactate (P=0.01). miR-146a and miR-223 demonstrated no significantly diagnostic or prognostic ability in this cohort. miR-150 was associated with inflammation, severity of illness, and mortality. Given the independent predictive value of miR-150, additional research regarding its role in sepsis is warranted.
Advanced Fiber Designs and Their Applications in Transmission (2018)

It is possible to create advanced, manufacturable designs for both single- and multi-mode optical fibers that give significant performance improvements in transmission. This tutorial gives practical illustrations for both datacom and coherent long haul applications.
Alternative cleavage and polyadenylation in spermatogenesis connects chromatin regulation with post-transcriptional control (2016)

Our data suggest that open chromatin may create a favorable cis environment for 3' end processing, leading to global shortening of 3'UTR during spermatogenesis. mRNAs with shortened 3'UTRs are relatively stable thanks to evasion of powerful mRNA degradation mechanisms acting on 3'UTR elements. Stable mRNAs generated in spermatids may be important for protein production at later stages of sperm maturation, when transcription is globally halted.
Pertuzumab and Trastuzumab: Re-Responses to 2 Biological Agents in Patients with HER2-Positive Breast Cancer Which Had Previously Progressed during Therapy with Each Agent Given Separately: A New Biological and Clinical Observation. (2009)

Abstract Background: Pertuzumab, a fully humanised IgG1 monoclonal antibody, is a human epidermal growth factor receptor 2 (HER2)-dimerisation inhibitor directed to the dimerisation epitope of HER2 (trastuzumab binds to the juxta-membrane epitope). Pertuzumab has demonstrated promising activity when given with trastuzumab to patients with HER2-positive metastatic breast cancer (mBC) which had progressed during therapy with trastuzumab in a 2-step Phase II study.1Methods: The protocol was amended to include a 3rd cohort of patients to determine the activity of pertuzumab when given without trastuzumab.2 Patients recruited into this 3rd cohort were allowed to have trastuzumab re-introduced in combination with pertuzumab if there was inadequate response to pertuzumab alone or response followed by relapse.Results: Twenty-nine patients were recruited into this 3rd cohort. Patients had reached their 3rd line of treatment for mBC. To date, 15 patients have had trastuzumab re-introduced after disease progression on trastuzumab therapy and pertuzumab monotherapy. Among these 15 patients, at the time of this analysis there have been 3 patients with confirmed responses. There are also 4 patients who had not yet undergone 8 cycles of assessments to reach the overall best response end point, of which at least 2 were experiencing stablisation of disease. Updated data on activity and toxicity will be presented.Conclusions: We believe this is the first time that anti-tumour activity has been reported in patients when 2 biological agents have been used together after the disease has progressed during therapy with each agent alone. There are several mechanisms which might explain this phenomenon. Trastuzumab prevents proteolytic cleavage of the extracellular domain of HER2, keeping the receptor in situ. The addition of a second antibody to a separate epitope increases the potential for antibody-dependent cell-mediated cytotoxicity and prevents dimerisation between HER2 and other HER family members, such as HER1 and HER3. The combined antibodies might increase the efficiency of inhibition of signal transduction. There are wide-ranging and potentially significant biological and clinical implications. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5114.
Tailoring Second Harmonic Diffraction in GaAs Metasurfaces via Crystal Orientation (2019)

We use GaAs metasurfaces with (111) crystal orientation to channel the second harmonic generation (SHG) into the zero-diffraction order that is suppressed for SHG obtained from GaAs metasurfaces with (100) orientation.
Surface Charge of Polymer Particles in Water: The Role of Ionic End-Groups (2013)

Polymer particles, containing macromolecules made by the polymerization of nonionic monomers, can be ionized in water thanks to the end-groups of the macromolecules. We show that poly(methylmethacrylate) particles with ionic end-groups can acquire colloidal properties such as dispersion metastability and electrokinetic mobility. We demonstrate that the variation of these colloidal properties according to solution pH is uniquely determined by the chemical nature of the end-groups and therefore by the nature of the initiator used in the polymerization reaction. We compare polymer dispersions in which the polymer particles were made by different processes (e.g., surfactant-free emulsion polymerization or precipitation of the macromolecules induced by solvent shifting). For each colloidal dispersion, we determine the number of end-groups that are actually located at the surfaces of the particles, and we show that this number is a trace of the process by which the macromolecules were self-assembled into colloidal particles. We propose that it is possible to recover mechanistic details of this self-assembly process through measurements of the distribution of end-groups within the particles.
Microfabrication of SrRuO3 thin films on various oxide substrates using LaAlO3/BaOx sacrificial bilayers (2018)

Oxides provide various fascinating physical properties that could find use in future device applications. However, the physical properties of oxides are often affected by formation of oxygen vacancies during device fabrication processes. In this study, to develop a damage-free patterning process for oxides, we focus on a lift-off process using a sacrificial template layer, by which we can pattern oxide thin films without severe chemical treatment or plasma bombardment. As oxides need high thin-film growth temperature, a sacrificial template needs to be made of thermally stable and easily etchable materials. To meet these requirements, we develop a sacrificial template with a carefully designed bilayer structure. Combining a thermally and chemically stable LaAlO<sub>3</sub> and a water-soluble BaO<sub>x</sub>, we fabricated a LaAlO<sub>3</sub>/BaO<sub>x</sub> sacrificial bilayer. The patterned LaAlO<sub>3</sub>/BaO<sub>x</sub> sacrificial bilayers were prepared on oxide substrates by room-temperature pulsed laser deposition and standard photolithography process. The structure of the sacrificial bilayer can be maintained even in rather tough conditions needed for oxide thin film growth: several hundred degrees Celsius under high oxygen pressure. Indeed, the LaAlO<sub>3</sub>/BaO<sub>x</sub> bilayer is easily removable by sonication in water. We applied the lift-off method using the LaAlO<sub>3</sub>/BaO<sub>x</sub> sacrificial bilayer to a representative oxide conductor SrRuO<sub>3</sub> and fabricated micron-scale Hall-bar devices. The SrRuO<sub>3</sub> channels with the narrowest line width of 5 &mu;m exhibit an almost identical transport property to that of the pristine film, evidencing that the developed process is beneficial for patterning oxides. We show that the LaAlO<sub>3</sub>/BaO<sub>x</sub> lift-off process is applicable to various oxide substrates: SrTiO<sub>3</sub>, MgO, and Al<sub>2</sub>O<sub>3</sub>. The new versatile patterning process will expand the range of application of oxide thin films in electronic and photonic devices.
Trifluoromethanesulfonyl Azide:  A Powerful Reagent for the Preparation of α-Nitro-α-diazocarbonyl Derivatives (2000)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTTrifluoromethanesulfonyl Azide: A Powerful Reagent for the Preparation of α-Nitro-α-diazocarbonyl DerivativesAndré B. Charette, Ryan P. Wurz, and Thierry OllevierView Author Information Département de Chimie, Université de Montréal, P.O. Box 6128, Station Downtown, Montréal (Québec) Canada, H3C 3J7 [email protected]Cite this: J. Org. Chem. 2000, 65, 26, 9252–9254Publication Date (Web):November 30, 2000Publication History Received14 August 2000Published online30 November 2000Published inissue 1 December 2000https://pubs.acs.org/doi/10.1021/jo001235whttps://doi.org/10.1021/jo001235wbrief-reportACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views2437Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Azides,Organic compounds,Precursors,Reaction products,Reagents Get e-Alerts
1530: Nephrolithiasis in Identical Twins - The Impact of Nature vs. Nurture (2006)

You have accessJournal of UrologyModerated Poster, Wednesday, May 24, 2006, 10:00 am - 12:00 pm1 Apr 20061530: Nephrolithiasis in Identical Twins - The Impact of Nature vs. Nurture George E. Haleblian, Roger L. Sur, Asher Cantor, Kristy M. Borawski, David Kang, Dean G. Assimos, and Glenn M. Preminger George E. HaleblianGeorge E. Haleblian , Roger L. SurRoger L. Sur , Asher CantorAsher Cantor , Kristy M. BorawskiKristy M. Borawski , David KangDavid Kang , Dean G. AssimosDean G. Assimos , and Glenn M. PremingerGlenn M. Preminger View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33734-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1530: Nephrolithiasis in Identical Twins - The Impact of Nature vs. Nurture." The Journal of Urology, 175(4S), p. 494 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 494 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information George E. Haleblian More articles by this author Roger L. Sur More articles by this author Asher Cantor More articles by this author Kristy M. Borawski More articles by this author David Kang More articles by this author Dean G. Assimos More articles by this author Glenn M. Preminger More articles by this author Expand All Advertisement PDF downloadLoading ...
Reduction of pattern dependent stimulated Raman scattering crosstalk by codirectional Raman pumping (2002)

Pattern dependent crosstalk in a 160×10Gbit/s DWDM transmission system induced by stimulated Raman scattering was analyzed experimentally. Reduction of the crosstalk magnitude by the application of codirectional Raman pumping could be demonstrated.
Development of Injectable O-15 Oxygen and Estimation of Rat OEF (2003)

Cerebral metabolic rate for oxygen (CMRO(2)) and cerebral oxygen extraction fraction (OEF) are some of the most fundamental parameters to characterize the pathophysiologic status of cerebral tissue. Although O-15-labeled gases inhalation method is performed in clinical studies, application of the inhalation method on small animals requires too many intensive procedures. On this basis, the development of a new method to measure CMRO(2) and OEF in small animals is of interest. This study was aimed at developing a method to assess CMRO(2) and OEF using intravenously injectable oxygen (injectable 15O-O(2)) for small animals such as rats. Injectable 15O-O(2), 72 MBq/mL of radioactivity, was obtained after 15O-O(2) gas circulation into the artificial lung. OEF after injection of injectable 15O-O(2) was calculated using the same equation as that applied to the bolus inhalation of 15O-O(2) gas method. Values of 44 +/- 4.5 mL. min-1. 100 g-1 of CBF and 0.54 +/- 0.11 of OEF were obtained (n = 13). This OEF value was well accordance with OEF evaluated by arterial-venous difference of oxygen concentration (0.57 +/- 0.13). This method is useful to study the CMRO(2) and OEF in small animals using an animal positron emission tomography system. It may accelerate the basic research of several cerebral perfusion diseases.
TU‐AB‐BRA‐12: Quality Assurance of An Integrated Magnetic Resonance Image Guided Adaptive Radiotherapy Machine Using Cherenkov Imaging (2016)

Purpose: To investigate the viability of using Cherenkov imaging as a fast and robust method for quality assurance tests in the presence of a magnetic field, where other instruments can be limited. Methods: Water tank measurements were acquired from a clinically utilized adaptive magnetic resonance image guided radiation therapy (MR‐IGRT) machine with three multileaf‐collimator equipped 60Co sources. Cherenkov imaging used an intensified charge coupled device (ICCD) camera placed 3.5m from the treatment isocenter, looking down the bore of the 0.35T MRI into a water tank. Images were post‐processed to make quantitative comparison between Cherenkov light intensity with both film and treatment planning system predictions, in terms of percent depth dose curves as well as lateral beam profile measurements. A TG‐119 commissioning test plan (C4: C‐Shape) was imaged in real‐time at 6.33 frames per second to investigate the temporal and spatial resolution of the Cherenkov imaging technique. Results: A .33mm/pixel Cherenkov image resolution was achieved across 1024×1024 pixels in this setup. Analysis of the Cherenkov image of a 10.5×10.5cm treatment beam in the water tank successfully measured the beam width at the depth of maximum dose within 1.2% of the film measurement at the same point. The percent depth dose curve for the same beam was on average within 2% of ionization chamber measurements for corresponding depths between 3–100mm. Cherenkov video of the TG‐119 test plan provided qualitative agreement with the treatment planning system dose predictions, and a novel temporal verification of the treatment. Conclusions: Cherenkov imaging was successfully used to make QA measurements of percent depth dose curves and cross beam profiles of MRI‐IGRT radiotherapy machines after only several seconds of beam‐on time and data capture; both curves were extracted from the same data set. Video‐rate imaging of a dynamic treatment plan provided new information regarding temporal dose deposition. This study has been funded by NIH grants R21EB17559 and R01CA109558, as well as Norris Cotton Cancer Center Pilot funding.