gebhart/patrepeval huggingface dataset:
Processable aromatic polyimides (1985)

Abstract Two similar polyimide systems were synthesized and characterized. The only structural difference was a sulfide linkage in the anhydride‐derived portion of the first system vs. a sulfone linkage in the second. Their physical, mechanical, melt‐flow and thermal properties, and their resistance to some of the more common solvents were determined. The flow properties of these polyimides indicate a potential for melt processability.
Mutational analysis of an autoantibody: differential binding and pathogenicity. (1994)

We have used site-directed mutagenesis to change amino acid residues in the heavy chain of the pathogenic R4A anti-double-stranded DNA (dsDNA) antibody and have looked for resultant alterations in DNA binding and in pathogenicity. The data demonstrate that single amino acid substitutions in both complementarity determining and framework regions alter antigen binding. Changes in only a few amino acids entirely ablate DNA specificity or cause a 10-fold increase in relative binding. In vivo studies in mice of the pathogenicity of the mutated antibodies show that a single amino acid substitution leading to a loss of dsDNA binding leads also to a loss of glomerular sequestration. Amino acid substitutions that increase relative affinity for dsDNA cause a change in localization of immunoglobulin deposition from glomeruli to renal tubules. These studies demonstrate that small numbers of amino acid substitutions can dramatically alter antigen binding and pathogenicity, and that the pathogenicity of anti-DNA antibodies does not strictly correlate with affinity for DNA.
Diabetes Mellitus Is Associated With an Exocrine Pancreatopathy (2016)

In types 1 and 2 DM, moderate-to-severe subclinical pancreatic fibrosis and modest exocrine dysfunction occurs in the absence of clinical or histopathological evidence of chronic pancreatitis. We call this novel entity "diabetic exocrine pancreatopathy."
Weight loss caused by visceral artery disease. (2013)

Dramatic unintentional weight loss can be caused by a spectrum of diseases ranging from very serious to benign and treatable. We describe the case of a 70-year-old woman with an extensive history of cardiovascular disease who presented with unintentional weight loss. Although she was diagnosed and treated for colitis, the patient continued to lose 50 pounds over 8 months, which prompted an angiogram. The angiogram revealed occlusion of her superior and inferior mesenteric arteries just distal to their origins, together with high-grade (80%-90%) stenosis at the origin of the celiac axis. After a stent was placed in the ostium of the celiac axis, the patient immediately began to regain weight. We suggest that clinicians consider chronic mesenteric ischemia when treating patients with undiagnosed unintentional weight loss and a history of atherosclerotic disease.
N,N‐Dialkylated 4‐(4‐Arylsulfonylpiperazine‐1‐carbonyl)‐benzamidines and 4‐((‐4‐Arylsulfonyl)‐2‐oxo‐piperazin‐1‐ylmethyl)‐benzamidines as Potent Factor Xa Inhibitors. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Wide spurious free range positive-to-negative inter-resonator coupling structure for reconfigurable filters (2013)

A structure for positive-to-negative inter-resonator coupling in cavity resonator filters is shown in this paper. Mechanically and electrically reconfigurable versions of the structure are described. The structure has a wide spurious free range while retaining the capability to provide near-zero coupling because it uses symmetry to redirect digitally addressable amounts of current to adjust coupling values instead of using the phase shift through a resonance. It is applied to 6-resonator cross-coupled filters whose response can be adjusted between several different orders and shapes, including shapes with and without transmission zeros. A technique for improving the near-zero coupling state is also presented.
Willingness to Consult a Veterinarian on Physician’s Advice for Zoonotic Diseases: A Formal Role for Veterinarians in Medicine? (2015)

Physicians appear to find zoonotic diseases a challenge and consider that this topic belongs more to the veterinary profession. However, veterinarians have no formal role in clinical medicine. Data were collected as part of the Queensland Social Survey 2014 to determine the willingness of the public, if diagnosed with a zoonotic disease, to consult a veterinarian on the advice of a physician. Self-reported willingness to consult with a veterinarian at the respondent's own expense was 79.8% (95% CI: 81.96%-77.46%) (976/1223). If the cost was funded by Medicare, the Australian public health insurance scheme, 90.7% (95% CI: 92.18%-88.92%) (1109/1223) would be willing to consult a veterinarian. Therefore, a large majority of Australian residents would be willing to consult with a veterinarian on the advice of their physician if they had a zoonotic disease. Does this indicate a possible new role for veterinarians under Clinical One Health?
Role of the Neuropathology of Alzheimer Disease in Dementia in the Oldest-Old (2008)

These findings suggest that the neuropathological features of dementia in the oldest-old are not the same as those of cognitively impaired younger-old persons and compel a vigorous search for neuropathological indices of dementia in this most rapidly growing segment of the elderly population.
Identification and Functional Validation of the Novel Antimalarial Resistance Locus PF10_0355 in Plasmodium falciparum (2011)

The Plasmodium falciparum parasite's ability to adapt to environmental pressures, such as the human immune system and antimalarial drugs, makes malaria an enduring burden to public health. Understanding the genetic basis of these adaptations is critical to intervening successfully against malaria. To that end, we created a high-density genotyping array that assays over 17,000 single nucleotide polymorphisms (∼ 1 SNP/kb), and applied it to 57 culture-adapted parasites from three continents. We characterized genome-wide genetic diversity within and between populations and identified numerous loci with signals of natural selection, suggesting their role in recent adaptation. In addition, we performed a genome-wide association study (GWAS), searching for loci correlated with resistance to thirteen antimalarials; we detected both known and novel resistance loci, including a new halofantrine resistance locus, PF10_0355. Through functional testing we demonstrated that PF10_0355 overexpression decreases sensitivity to halofantrine, mefloquine, and lumefantrine, but not to structurally unrelated antimalarials, and that increased gene copy number mediates resistance. Our GWAS and follow-on functional validation demonstrate the potential of genome-wide studies to elucidate functionally important loci in the malaria parasite genome.
Primary Graft Dysfunction in Lung Transplantation: A Review of Mechanisms and Future Applications (2023)

Lung allograft recipients have worse survival than all other solid organ transplant recipients, largely because of primary graft dysfunction (PGD), a major form of acute lung injury affecting a third of lung recipients within the first 72 h after transplant. PGD is the clinical manifestation of ischemia-reperfusion injury and represents the predominate cause of early morbidity and mortality. Despite PGD's impact on lung transplant outcomes, no targeted therapies are currently available; hence, care remains supportive and largely ineffective. This review focuses on molecular and innate immune mechanisms of ischemia-reperfusion injury leading to PGD. We also discuss novel research aimed at discovering biomarkers that could better predict PGD and potential targeted interventions that may improve outcomes in lung transplantation.
Laschiatrion, a New Antifungal Agent from a Favolaschia Species (Basidiomycetes) Active Against Human Pathogens. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Novel Low-Overhead Operand Isolation Techniques for Low-Power Datapath Synthesis (2006)

Power consumption in datapath modules due to redundant switching is an important design concern for high-performance applications. Operand isolation schemes that reduce this redundant switching incur considerable overhead in terms of delay, power, and area. This paper presents novel operand isolation techniques based on supply gating that reduce overheads associated with isolating circuitry. The proposed schemes also target leakage minimization and additional operand isolation at the internal logic of datapath to further reduce power consumption. We integrate the proposed techniques and power/delay models to develop a synthesis flow for low-power datapath synthesis. Simulation results show that the proposed operand isolation techniques achieve at least 40% reduction in power consumption compared to original circuit with minimal area overhead (5%) and delay penalty (0.15%)
Towards the energy efficient future factory (2009)

Up to now, most factories and their processes were designed and constructed with the cost as the most important economic factor. However due to the increased changes in energy sector, the energy optimization should be another key indicator for cross layer optimization. In order to achieve this optimization, energy has to be measured locally and almost in real time, while manufacturing control activities should also be aware of the energy consumed. Furthermore higher-residing decision support systems and enterprise services, will take also into consideration the overall energy consumption, for each process and optimize globally and locally. These goals are assisted with the increasing automation within the factories that can provide better visibility and efficiency of the shop floor.
José Saramago: evaluating History, evaluating the human (2020)

Neste artigo, proponho-me fundamentar uma tese tão divulgada quanto ainda não devidamente esclarecida: José Saramago não era otimista em relação à(s) natureza(s) humana(s) e ao devir da História, e a prová-lo temos tanto os seus depoimentos como a sua escrita literária. Para o autor de Folhas Políticas (1999), ao contrário do que preconizam tanto os marxistas-leninistas como os liberais e os neoliberais mais ortodoxos, algures no futuro não está necessariamente o bem: nem aquele bem que uns dizem decorrer das leis inflexíveis da História, nem aquele que outros afirmam resultar da Providência (da vontade de Deus) e/ou dos mercados sem regulação estatal e internacional. Pretendo evidenciar que Saramago nunca defendeu a existência de leis da História predeterminadas e imutáveis, nem se deixou seduzir pela vitória tantas vezes anunciada e definitiva do bem.
TEMPERATURE VARIATION, HEAT TRANSFER, AND VOID VOLUME DEVELOPMENT IN THE TRANSIENT ATMOSPHERIC BOILING WATER (1961)

Experimental determinations of surface temperature, and the volume of vapor produced are given for the atmospheric pool boiling of water on metallic ribbons in which energy is uniformly generated at an exponentially increasing rate in time. The subcooling of the pool was varied between 2 and 112 deg F and the period of the transient pulse ranges between 5 and 80 milliseconds. These conditions are typical of those in a nuclear reactor experiencing a prompt- critical excursion. The effeets of thermal capacity of the ribbon and orientation of the heating surface were also studied. These results exhibited decided trends although, since the system was extremely sensitive to minor random variations, they were reproducible only within limits that wvere necessarily broad. No general correlations wcre formed, but a method for predicting the rate of vapor volume development was devised and applied with some suceess in the case of saturated transient boiling. The effects of pressure and velocity are presently being studied. (auth)
Supplemental Methods, Figures and Tables from Circulating Tumor DNA as a Clinical Test in Resected Pancreatic Cancer (2023)

&lt;p&gt;Supplemental Methods, Figures and Tables&lt;/p&gt;
The genetic causes of basal ganglia calcification, dementia, and bone cysts (2005)

Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy should be considered in adult patients under age 50 years with dementia and basal ganglia calcification. Radiographs of ankles and wrists, and DNA test in uncertain cases, confirm the diagnosis.
Calculation of quadratic hyperpolarizabilities for organic π electron chromophores: Molecular geometry sensitivity of second‐order nonlinear optical response (1992)

Abstract This contribution explores the sensitivity of computed quadratic hyperpolarizabilities to the choice of chromophore molecular geometry. The nonlinear optical response of 25 organic π‐electron molecular chromophores is calculated for four different types of input geometries using the ZINDO‐SOS formalism. The calculated nonlinear optical susceptibilites are found to be surprisingly sensitive to certain key alternations in molecular structure; this is understandable in terms of modifications in the conjugation strength through the π system. We also describe an efficient, a priori prescription for constructing chromophore input geometries that yield accurate quadratic hyper‐polarizabilities within the ZINDO‐SOS formalism. The first optical absorption maxima, the dipole moments, and the second‐order nonlinear optical responses computed from these idealized geometries are essentially identical to those derived from MOPAC‐optimized structures and correspond well with available experimental data.
Diagnóstico de nematodos fitoparásitos en plátano (Musa AAB) cv. Hartón en el Sur del Lago de Maracaibo Diagnostic of plant-parasitic nematodes in plantain (Musa AAB) cv. Hartón at the southern of Maracaibo Lake (2011)

1Programa Ingenieria de la Produccion Agropecuaria. Universidad Nacional Experimental Sur del Lago (UNESUR). Santa. Barbara del Zulia, Venezuela. Apdo. postal 5148. 2Dpto. Fitosanitario. Instituto de Investigaciones Agronomicas. Facultad de Agronomia. Universidad del Zulia. Maracaibo, ZU4005, Venezuela. 3Posgrado de Fitopatologia. Universidad Centroccidental Lisandro Alvarado, Barquisimeto, estado Lara.
Effect of Rebamipide Ophthalmic Suspension on Optical Quality in the Short Break-up Time Type of Dry Eye (2013)

Rebamipide administered to treat the short BUT type of dry eye significantly improved optical quality because of the improvement in tear stability.
Weakly-Supervised Deep Recurrent Neural Networks for Basic Dance Step Generation (2019)

Synthesizing human's movements such as dancing is a flourishing research field which has several applications in computer graphics. Recent studies have demonstrated the advantages of deep neural networks (DNNs) for achieving remarkable performance in motion and music tasks with little effort for feature pre-processing. However, applying DNNs for generating dance to a piece of music is nevertheless challenging, because of 1) DNNs need to generate large sequences while mapping the music input, 2) the DNN needs to constraint the motion beat to the music, and 3) DNNs require a considerable amount of hand-crafted data. In this study, we propose a weakly supervised deep recurrent method for real-time basic dance generation with audio power spectrum as input. The proposed model employs convolutional layers and a multilayered Long Short-Term memory (LSTM) to process the audio input. Then, another deep LSTM layer decodes the target dance sequence. Notably, this end-to-end approach has 1) an auto-conditioned decode configuration that reduces accumulation of feedback error of large dance sequence, 2) uses a contrastive cost function to regulate the mapping between the music and motion beat, and 3) trains with weak labels generated from the motion beat, reducing the amount of hand-crafted data. We evaluate the proposed network based on i) the similarities between generated and the baseline dancer motion with a cross entropy measure for large dance sequences, and ii) accurate timing between the music and motion beat with an F-measure. Experimental results revealed that, after training using a small dataset, the model generates basic dance steps with low cross entropy and maintains an F-measure score similar to that of a baseline dancer.
Site-specific delivery of polymeric encapsulated microorganisms: a patent evaluation of US20170165201A1 (2018)

Probiotics inculde live microorganisms therapeutically effective in the treatment of wide range of diseases. Probiotics possibly stimulates the growth of preferred microorganisms, crowds out potentially harmful microorganisms, and reinforces the body's natural defense mechanisms. Microencapsulation of probiotic microorganisms protects them from the destructive environment and prolongs their survival. Use of mucoadhesive and pH responsive polymers could impart extended retention, pH sensitive release and mucoadhesive properties to the system. The probiotic formulations could be used for therapeutic, diagnostic, and prophylactic purposes. Areas covered: Layer-by-layer techology was developed for encapsulating Bacillus coagulans employing chitosan and alginate as mucoadhesive polymers (for attachment to the gastrointestinal mucosa) and Eudragit EPO and Eudragit L100 as pH responsive polymers (for site-specific delivery). The formulation was evaluated for layer stability, mucoadhesion capability, protection of microorganisms from biological insults, pH responsive layer removal, in vitro evaluation in three-dimensional intestinal tissue model, probiotic bacterial delivery. Expert opinion: In this patent, a unique layer-by-layer assembly of two differently charged polymers (mucoadhesive and pH repsonsive) was achieved for encapsulating the probiotic microorganism. For assessing the clinical applicability of the invention, further studies may be needed since the conclusions are drawn solely based on in vitro data.
Organocatalytic Asymmetric Mannich Reactions: New Methodology, Catalyst Design, and Synthetic Applications (2007)

Abstract The direct, asymmetric Mannich reaction catalyzed by small organic molecules offers a facile route to optically active α‐ or β‐amino acid derivatives and 1,2‐ and γ‐amino alcohols. One‐pot reactions of unmodified carbonyl donors with preformed or in situ generated imines can be stereochemically controlled with Organic catalysts such as proline, chiral pyrrolidines, chiral Brønsted acids, and Cinchona alkaloids. The generated Mannich adducts can be further functionalized towards a variety of bioactive molecules. In this Microreview, recent contributions are discussed to present the methodology and synthetic advantages achieved so far in the asymmetric Mannich reaction. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2007)
A new polymorphic probe on chromosome 3p: λLIB49-60 [D3S155] (1989)

2LIB49-60 is a 4.3 kb EcoR I fragment isolated from a Charon 21A human chromosome 3 library (1). POLYMORPHISM: Taq I digestion of genomic DNA and hybridization with this probe detects a two allele polymorphism: 2.1 kb (TI) and 1.5/0.6 kb (T2). Constant bands are present at 1.0 and 0.8 kb. FREOUENCY: Estimated from 25 unrelated Caucasians.
Unveiling the mechanism of the photocatalytic reduction of CO2to formate promoted by porphyrinic Zr-based metal–organic frameworks (2022)

A complete picture of the reaction mechanism driving the photocatalytic reduction of CO 2 into formate promoted by the Zr-based porphyrinic MOF-545 in CH 3 CN/TEOA solutions is provided for the first time by combining experimental and computational approaches.
A Novel NF-κB Complex Containing p65 Homodimers: Implications for Transcriptional Control at the Level of Subunit Dimerization (1993)

The predominant inducible form of the NF-kappa B transcription factor is a heteromeric complex containing two Rel-related DNA-binding subunits, termed p65 and p50. Prior transfection studies have shown that when these p65 and p50 subunits are expressed independently as stable homodimers, p65 stimulates kappa B-directed transcription, whereas p50 functions as a kappa B-specific repressor. While authentic p50 homodimers (previously termed KBF1) have been detected in nuclear extracts from nontransfected cells, experimental evidence supporting the existence of p65 homodimers in vivo was lacking. We now provide direct biochemical evidence for the presence of an endogenous pool of inducible p65 homodimers in intact human T cells. As with the prototypical NF-kappa B p50-p65 heterodimer, this novel p65 homodimeric form of NF-kappa B is functionally sequestered in the cytoplasm but rapidly appears in the nuclear compartment following cellular stimulation. Site-directed mutagenesis studies indicate that the homodimerization function of p65 is dependent upon the presence of cysteine 216 and a conserved recognition motif for protein kinase A (RRPS; amino acids 273 to 276), both of which reside within a 91-amino-acid segment of the Rel homology domain that mediates self-association. In contrast, mutations at these two sites do not affect heterodimerization of p65 with p50 or its functional interaction with I kappa B alpha. These later findings indicate that neither homo- nor heterodimer formation is an absolute prerequisite for I kappa B alpha recognition of p65. Taken together with prior in vivo transcription studies, these results suggest that the biological activities of p65 and p50 homodimers are independently regulated, thereby providing an integrated and flexible control mechanism for the rapid activation and repression of NF-kappa B/Rel-directed gene expression.
Comparative genomic hybridization analysis of clear cell sarcoma of the kidney (2000)

These results are consistent with previous findings of limited chromosomal changes in CCSK karyotypes. Gain of 1 q in CCSK warrants further investigation. Copy number gains of 1 q have been repeatedly demonstrated in soft tissue and bone sarcomas, as well as other tumors, implying the presence of genes involved in tumor development and/or progression.
Constant <italic>ΔT<sub>j</sub> </italic> Power Cycling Strategy in DC Mode for Top-Metal and Bond-Wire Contacts Degradation Investigations (2018)

The study of the impact of junction temperature swings (ΔTj) on degradation mechanisms during power cycling tests (PCTs) requires both a control of the applied thermal stress and a separation of degradation modes. The first requirement can be obtained by using a “constant ΔTj” power cycling strategy that allows to minimize the cross interactions between the influencing factors. The second one is made by using a dedicated power module well suited for targeting only the chips top-side degradations (metallization and bond-wire contacts). In this paper, a constant ΔTj strategy by gate voltage regulation is performed for PCTs in the dc mode. The tested modules are ideally designed for top-metal and bond-wire contacts degradation investigations. From aging indicator on the collector-emitter voltage (VCE), the results clearly show that three regimes of degradation occur systematically at the insulated gate bipolar transistor (IGBT) chips top side, whatever the stress conditions. Moreover, comparative results in “constant ΔTj” and conventional “constant ΔI” PCT strategies have shown that the feedback between stresses and damages encountered in the second strategy is more important for low ΔTj values than for high ΔTj values. In addition, results show that in case of high stresses, the “constant ΔTj” strategy with VGE regulation gives values close to a “constant ΔI” strategy but that the extrapolation toward low values of ΔTj can be questionable for the “constant ΔTj” strategy.