gebhart/patrepeval huggingface dataset:
Faculty Opinions recommendation of TRPV1 in brain is involved in acetaminophen-induced antinociception. (2011)

Background: Acetaminophen, the major active metabolite of acetanilide in man, has become one of the most popular overthe-counter analgesic and antipyretic agents, consumed by millions of people daily. However, its mechanism of action is still a matter of debate. We have previously shown that acetaminophen is further metabolized to N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z -eicosatetraenamide (AM404) by fatty acid amide hydrolase (FAAH) in the rat and mouse brain and that this metabolite is a potent activator of transient receptor potential vanilloid 1 (TRPV 1 ) in vitro. Pharmacological activation of TRPV 1 in the midbrain periaqueductal gray elicits antinociception in rats. It is therefore possible that activation of TRPV 1 in the brain contributes to the analgesic effect of acetaminophen.
Interleukin-8 Controls Bacterial Transepithelial Translocation at the Cost of Epithelial Destruction in Experimental Shigellosis (1999)

In shigellosis, the network of cellular interactions mediated by a balance of pro- and anti-inflammatory cytokines or chemokines is clearly tipped toward acute destructive inflammation of intestinal tissues by the bacterial invader. This work has addressed the role played by interleukin-8 (IL-8) in a rabbit model of intestinal invasion by Shigella flexneri. IL-8, which is largely produced by the epithelial cells themselves, appears to be a major mediator of the recruitment of polymorphonuclear leukocytes (PMNs) to the subepithelial area and transmigration of these cells through the epithelial lining. Neutralization of IL-8 function by monoclonal antibody WS-4 caused a decrease in the amount of PMNs streaming through the lamina propria and the epithelium, thus significantly attenuating the severity of epithelial lesions in areas of bacterial invasion. These findings are in agreement with our previous work (31). In contrast to the PMNs, the bacteria displayed increased transepithelial translocation, as well as overgrowth in the lamina propria and increased passage into the mesenteric blood. By mediating eradication of bacteria at their epithelial entry site, although at the cost of severe epithelial destruction, IL-8 therefore appears to be a key chemokine in the control of bacterial translocation.
Differential near-field scanning optical microscopy (2007)

A new aperture-type near-field scanning optical microscopy (NSOM) technique, termed differential NSOM (DNSOM) is illustrated. DNSOM utilizes sharp corners of an aperture to beat diffraction-limit, and unlike conventional NSOM, the size of the aperture does not determine the resolution.
Megasonics: A Cavitation Driven Process (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Voice biometrics: perspective from the industry (2021)

Chapter Contents: 8.1 Automated password reset: an example of a commercial application using voice biometrics 8.1.1 Overview 8.1.2 Introduction 8.1.3 System architecture 8.1.4 Voice biometric system 8.1.5 Summary 8.2 Testing of commercial voice biometric systems 8.2.1 Introduction 8.2.1.1 Biometric testing 8.2.2 User analysis 8.2.3 Summary 8.3 Forensic speaker recognition 8.3.1 Introduction 8.3.2 Forensic speaker recognition and the strength of evidence 8.3.3 The forensic experts workflow 8.3.4 Technical challenges 8.3.4.1 Improving interpretability of scores 8.3.4.2 Score normalization 8.3.4.3 Score calibration 8.3.4.4 Condition adaptation 8.3.4.5 Dealing with multi-speaker recordings 8.3.5 Training—communication between system developers and end-users 8.3.6 Conclusions References
Humeral Head Shape in Native and Prosthetic Joint Replacement (2019)

A nonspherical prosthetic may influence long-term clinical outcomes in hemiarthroplasty and anatomic total shoulder arthroplasty though further research in this area is necessary.
Three Dimensional Behavior of Fully Compliant Bistable Micromechanisms (2008)

An improved understanding of the three-dimensional behavior of fully compliant bistable micromechanisms (FCBMs) would facilitate their appropriate implementation in applications such as threshold sensing arrays. A 3-D finite element model was developed to analyze the motion of a nominal FCBM design with various eccentric and off-axis loading conditions. Roll, pitch, and yaw rotations and Z-direction deflection results are presented for various loading conditions. Two distinct behaviors are discussed. Phenomenon 1 occurred when no off-axis loads were applied or when the magnitudes were small. Phenomenon 1 is characterized by shuttle motion with a relatively large pitch rotation. Phenomenon 2 occurred for larger magnitudes of off-axis loads, and was characterized by larger Z-direction deflections, lower actuation forces, and occasional loss of bistability.
Self-Organized Nano-Particles for Enhanced Wetting of Hard Surfaces∗∗ (2004)

Abstract Nano-particles or nanometer-thin layers are well established for permanent modification of hard surfaces. Depending on the physical and chemical properties, such films can lead to anti-scratch, anti-reflective and “self-cleaning” properties. The use of nano-particles and nanometer-thin polymeric films is also of interest for temporary applications. In this work it is shown that application of particle dispersions or polymers on hard ceramic surfaces can lead to distinct self-organization of the nano-particles due to electrostatic repulsion and surface free energy minimization. Some of the resulting semi-permanent surface modifications show reduced contact angles for hydrophilic liquids, which results in long-lasting effects of enhanced drainage, increased drying speed and reduced re-soiling. The self-organization of hydrophilic nano-sized particles with different size and surface characteristics is evaluated compared to polymeric surface modifiers.
Transrenal Arteriovenous Dialysis Graft Creation: Survival and Patency in a Swine Model (2003)

Transrenal arteriovenous graft creation in swine is technically feasible, and long-term patency is possible with antiplatelet therapy.
Conjugated MEMS Phased Arrays for Large Field of View Random Access Scanning (2020)

Multiple microelectromechanical system (MEMS) phased arrays in optical conjugation enable scanning over extended angular ranges beyond what is possible with a single device. We demonstrate this method for random access beam steering at 250 kHz using a MEMS phased array and a switchable grating modulator, achieving 4,352 resolvable lines from 2,176 line pairs over a field of view (FOV) of ±3.74° in the Fourier plane. With projection optics, this is extended to a far-field FOV of ±24.7° without reduction of the number of resolvable lines.
Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in Type 2 diabetes (2005)

PPL is associated with prolonged endothelial dysfunction for at least 8 h after a fatty meal. Vitamin C treatment improves endothelial dysfunction at all time points and attenuates PPL-induced oxidative stress. This highlights the importance of low-fat meals in T2DM and suggests a role for vitamin C therapy to improve endothelial function during meal ingestion.
Uterine cervical cancer associated with obstructed hemivagina and ipsilateral renal agenesis (OHVIRA) syndrome: A case report and review of the literature (2020)

•Cervical cancer occurring in patients with OHVIRA syndrome is very rare.•This case reports on HPV-negative adenocarcinoma located in the nonvisible cervix.•Colposcopy and imaging are essential for cervical cancer with uterine malformation.•In OHVIRA syndrome, cervical malignancies may be overlooked.
Assessing MAARDEC: A Comparison with Other Assistive Device Workshop and Disability Organization Models (Innovations Case Discussion: MAARDEC) (2008)

Appliances Research and Development Center (MAARDEC) features a multifaceted approach to serving the disabled community in Nigeria. In this issue of Innovations, Cosmas Okoli describes the system model he employs that goes beyond just providing mobility aids, including the mechanisms through which he is able to offer products and services that holistically improve the lives of people with disabilities. Although this model is not new and is practiced in similar forms by many other workshops in the developing world, it is insightful because it encompasses the range of disabled needs. Cosmas Okoli should be commended for working to provide opportunities, advocating for peoples’ rights, and running a sustainable organization that has multiple profit streams. Two major challenges face providers of mobility aids in developing countries: making and providing products that are appropriate for the environment in which they will be used, and finding financial mechanisms through which the products can be produced and purchased. Many of the products Okoli mentions in his article are innovative and were designed specifically for the Nigerian disabled. This is
Pulmonary aspergilloma, an unusual complication in Wegener’s granulomatosis (1982)

Abstract A patient with a limited form of Wegener’s granulomatosis is presented. The disease was complicated by the development of an aspergilloma in the excavated pulmonary infiltrate.
Whole Exome/Genome Sequencing Joint Analysis of a Family with Oligogenic Familial Hypercholesterolemia (2022)

Autosomal Dominant Hypercholesterolemia (ADH) is a genetic disorder caused by pathogenic variants in <i>LDLR</i>, <i>APOB</i>, <i>PCSK9</i> and <i>APOE</i> genes. We sought to identify new candidate genes responsible for the ADH phenotype in patients without pathogenic variants in the known ADH-causing genes by focusing on a French family with affected and non-affected members who presented a high ADH polygenic risk score (wPRS). Linkage analysis, whole exome and whole genome sequencing resulted in the identification of variants p.(Pro398Ala) in <i>CYP7A1</i>, p.(Val1382Phe) in <i>LRP6</i> and p.(Ser202His) in <i>LDLRAP1</i>. A total of 6 other variants were identified in 6 of 160 unrelated ADH probands: p.(Ala13Val) and p.(Aps347Asn) in <i>CYP7A1</i>; p.(Tyr972Cys), p.(Thr1479Ile) and p.(Ser1612Phe) in <i>LRP6</i>; and p.(Ser202LeufsTer19) in <i>LDLRAP1</i>. All six probands presented a moderate wPRS. Serum analyses of carriers of the p.(Pro398Ala) variant in <i>CYP7A1</i> showed no differences in the synthesis of bile acids compared to the serums of non-carriers. Functional studies of the four <i>LRP6</i> mutants in HEK293T cells resulted in contradictory results excluding a major effect of each variant alone. Within the family, none of the heterozygous for only the <i>LDLRAP1</i> p.(Ser202His) variant presented ADH. Altogether, each variant individually does not result in elevated LDL-C; however, the oligogenic combination of two or three variants reveals the ADH phenotype.
Uplink Physical Channel Structure (2009)

This chapter describes the channel structure used in the LTE uplink, focusing in particular on the different physical channels for the transmission of data (via the channel known as the PUSCH) and control signalling (via the channel known as the PUCCH). Data and control signalling are multiplexed together in a way which efficiently exploits the time-domain resources, while retaining the important single carrier property of the SC-FDMA scheme chosen for the LTE uplink. For data transmission, the chapter shows how the PUSCH can support both frequency-selective and frequency-diverse scheduling. For control signalling, the chapter explains in detail the various PUCCH formats which support transmission of different combinations of control information, consisting mainly of indicators used to support the downlink data transmission. The overall PUCCH structure is also described, showing how it follows from considerations of out-of-band emissions. Finally, the support of multiple transmit antenna techniques in the LTE uplink is discussed, including both closed-loop switched antenna diversity and multi-user Space Division Multiple Access.
Multiple Interactions across the Surface of the gp120 Core Structure Determine the Global Neutralization Resistance Phenotype of Human Immunodeficiency Virus Type 1 (2003)

Resistance to neutralization is an important characteristic of primary isolates of human immunodeficiency virus type 1 (HIV-1) that relates to the potential for successful vaccination to prevent infection and use of immunotherapeutics for treatment of established infection. In order to further elucidate mechanisms responsible for neutralization resistance, we studied the molecular mechanisms that determine the resistance of the primary virus isolate of the strain HIV-1 MN to neutralization by soluble CD4 (sCD4). As is the case for the global neutralization resistance phenotype, sCD4 resistance depended upon sequences in the amino-terminal heptad repeat region of gp41 (HR1), as well as on multiple functional interactions within the envelope complex. The functional interactions that determined the resistance included interactions between the variable loop 1 and 2 (V1/V2) region and sequences in or near the CD4 binding site (CD4bs) and with the V3 loop. Additionally, the V3 loop region was found to interact functionally with sequences in the outer domain of gp120, distant from the CD4bs and coreceptor-binding site, as well as with a residue thought to be located centrally in the coreceptor-binding site. These and previous results provide the basis for a model by which functional signals that determine the neutralization resistance, high-infectivity phenotype depend upon interactions occurring across the surface of the gp120 core structure and involving variable loop structures and gp41. This model should be useful in efforts to define epitopes that may be important for primary virus neutralization.
Color Management Using Optimal Three-Dimensional Look-Up Tables (2010)

Digital imaging has seen an unprecedented growth in the past five years. The variety of imaging systems available to users to create and view visual data is enormous. Color management has become an important aspect of modern imaging and display systems. Color profiles have been the de facto tool for achieving faithful visual reproduction for a long time. In this article, the authors discuss issues associated with profile-based color management systems. The authors describe an alternative approach motivated by the problem of visually matching two known display devices. The authors use a model-based method to achieve this goal and propose realizing the method with simple table look-up operations. The authors devise a framework for designing look-up tables (LUTs) which are optimal in terms of color reproduction on the displays based on resource constraints. The LUT-based color management system is shown to be more accurate and memory-efficient than a comparable International Color Consortium profile-based system.
Model for Evaluating Turbidity in Cloudy Beverages (1991)

ABSTRACT A model was developed to simulate diluted emulsions of clouding agents in beverages using uniform latex particles (ULP) at different concentrations and particle sizes ranging from 0.10 to 5.85 μm. The model allows determination of optimum concentration and diameter of suspended particles in diluted suspensions. Turbidity measurements showed that, for a given particle concentration, the haze of a diluted suspension reached a maximum when the diameter of the ULP was decreased to 0.2‐0.3 μm. A comparison of typical citrus oil in water beverage emulsions with diluted ULP suspensions showed that, when size of suspended oil globules was varied, a similar optimum particle size was found.
Optoelektronische Sensorik (2020)

No AccessHandbuch Bauelemente der OptikJan 2020Optoelektronische SensorikJürgen Bretschneider, Markus Keinath, Martin Löffler-MangJürgen Bretschneider, Markus Keinath, Martin Löffler-Manghttps://doi.org/10.3139/9783446461260.012SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2020Pages: 383-423Print ISBN: 978-3-446-46032-4eISBN: 978-3-446-46126-0 Copyright & Permissions© 2020 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Optimization of a Vertical Protection Level Equation for Dual Frequency SBAS (2011)

The advent of dual frequency Satellite Based Augmentation Systems (SBAS) will allow the aviation community to address some of the shortcomings of the current SBAS Minimum Operational Performance Standards (MOPS), in particular of the Vertical Protection Level (VPL), and also to adapt it to threats for a dual frequency user. First, satellite faults will become the dominant source of error – because the ionospheric delay threat is canceled. Second, it was discovered that there are nominal biases that cannot be corrected by the ground and that cause the current VPL to be inflated. Finally, actual data collected in support of system performance has shown that the statistics exhibit non-gaussian behavior. A Vertical Protection Level equation that addresses these points was proposed in [1]. This equation accounts explicitly for possible nominal biases and for the fact that the position error bound is dominated by one possible fault at a given time. The equation was evaluated using a Service Volume analysis tool and it was shown that it could provide significant benefits over the current equation. These simulations computed user coefficients (the coefficients that project the pseudorange onto the user position) based on a Least Squares (LS) approach. The LS approach is not optimal for the proposed VPL equation. In this paper we show that choosing optimally the coefficients that project the pseudoranges onto the position domain could significantly increase the performance of an SBAS based on the equation described in [1]. To this purpose, we will describe an algorithm that minimizes the Vertical Protection Level. Then, we will evaluate the availability benefits that can be obtained using the optimal algorithm using a Service Volume Analysis tool.
Input-powered energy harvesting interface circuits with zero standby power (2011)

This paper presents an input-powered energy-harvesting interface circuit that eliminates standby power consumption by automatically shutting down when the ac input voltage amplitude is too low for successful energy reclamation. The interface comprises an input-powered ac/dc converter and an input-powered dc/dc boost converter that are fabricated in ON Semi 3M-2P 0.5 μm CMOS process. The interface circuit starts up when the ac input amplitude exceeds 1 V and supplies a regulated dc output up to 3 V. When the input amplitude drops below 600 mV, the interface automatically enters standby mode and consumes no power. The system achieves a maximum efficiency of 60% with 1.5 V ac input amplitude and 3 V regulated dc output, delivering 3.9 mW of output power. The interface also functions properly in tests with an electrodynamic (magnetic) vibrational energy harvester.
Faculty Opinions recommendation of Discovery of a viral NLR homolog that inhibits the inflammasome. (2011)

The NLR (nucleotide binding and oligomerization, leucine-rich repeat) family of proteins senses microbial infections and activates the inflammasome, a multiprotein complex that promotes microbial clearance. Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to several human malignancies. We found that KSHV Orf63 is a viral homolog of human NLRP1. Orf63 blocked NLRP1-dependent innate immune responses, including caspase-1 activation and processing of interleukins IL-1β and IL-18. KSHV Orf63 interacted with NLRP1, NLRP3, and NOD2. Inhibition of Orf63 expression resulted in increased expression of IL-1β during the KSHV life cycle. Furthermore, inhibition of NLRP1 was necessary for efficient reactivation and generation of progeny virus. The viral homolog subverts the function of cellular NLRs, which suggests that modulation of NLR-mediated innate immunity is important for the lifelong persistence of herpesviruses. PMID: 21252346 Funding information This work was supported by: NCI NIH HHS, United States Grant ID: R01 CA096500 NIAID NIH HHS, United States Grant ID: F32 AI078735 NIDCR NIH HHS, United States Grant ID: R01 DE018281 NIAID NIH HHS, United States Grant ID: U54 AI057157 NCI NIH HHS, United States Grant ID: R01 CA096500-10 NIDCR NIH HHS, United States Grant ID: R01 DE018281-05 NIAID NIH HHS, United States Grant ID: T32-AI007001 NIAID NIH HHS, United States Grant ID: U19 AI077437 NIAID NIH HHS, United States Grant ID: AI91967 NIAID NIH HHS, United States Grant ID: T32-AI007419 NCI NIH HHS, United States Grant ID: CA156330 NIAID NIH HHS, United States Grant ID: AI56324 NIAID NIH HHS, United States Grant ID: R01 AI056324 NIAID NIH HHS, United States Grant ID: AI077437 NIAID NIH HHS, United States Grant ID: R01 AI091967 NIDCR NIH HHS, United States Grant ID: DE018281 NIAID NIH HHS, United States Grant ID: AI057157 NCI NIH HHS, United States Grant ID: 5R21CA131645 NCI NIH HHS, United States Grant ID: CA096500 NCI NIH HHS, United States Grant ID: R21 CA131645 NIAID NIH HHS, United States Grant ID: F32-AI78735 NIAID NIH HHS, United States Grant ID: T32 AI007419 NIAID NIH HHS, United States Grant ID: T32 AI007001 NCI NIH HHS, United States Grant ID: R01 CA156330 More Less keyboard_arrow_down
The Novel Diazoxide Analog 3-Isopropylamino-7-Methoxy-4H-1,2,4-Benzothiadiazine 1,1-Dioxide Is a Selective Kir6.2/SUR1 Channel Opener (2002)

ATP-sensitive K(+) (K(ATP)) channels are activated by a diverse group of compounds known as potassium channel openers (PCOs). Here, we report functional studies of the Kir6.2/SUR1 Selective PCO 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide (NNC 55-9216). We recorded cloned K(ATP) channel currents from inside-out patches excised from Xenopus laevis oocytes heterologously expressing Kir6.2/SUR1, Kir6.2/SUR2A, or Kir6.2/SUR2B, corresponding to the beta-cell, cardiac, and smooth muscle types of the K(ATP) channel. NNC 55-9216 reversibly activated Kir6.2/SUR1 currents (EC(50) = 16 micromol/l). This activation was dependent on intracellular MgATP and was abolished by mutation of a single residue in the Walker A motifs of either nucleotide-binding domain of SUR1. The drug had no effect on Kir6.2/SUR2A or Kir6.2/SUR2B currents. We therefore used chimeras of SUR1 and SUR2A to identify regions of SUR1 involved in the response to NNC 55-9216. Activation was completely abolished and significantly reduced by swapping transmembrane domains 8-11. The reverse chimera consisting of SUR2A with transmembrane domains 8-11 and NBD2 consisting SUR1 was activated by NNC 55-9216, indicating that these SUR1 regions are important for drug activation. [(3)H]glibenclamide binding to membranes from HEK293 cells transfected with SUR1 was displaced by NNC 55-9216 (IC(50) = 105 micromol/l), and this effect was impaired when NBD2 of SUR1 was replaced by that of SUR2A. These results suggest NNC 55-9216 is a SUR1-selective PCO that requires structural determinants, which differ from those needed for activation of the K(ATP) channel by pinacidil and cromakalim. The high selectivity of NNC 55-9216 may prove to be useful for studies of the molecular mechanism of PCO action.