gebhart/patrepeval huggingface dataset:
Behavioral Modeling of Concurrent Dual-Band Transmitters Based on Radially-Pruned Volterra Model (2015)

This paper presents a radially-pruned multi-dimensional Volterra model for the modeling and linearization of concurrent dual-band transmitters. The proposed model accounts for the impact of cross-band intermodulation distortions of the dual-band power amplifier (PA) and also the effect of quadrature modulator (QM) imperfections. The performance of the proposed model is validated using a broadband class AB PA driven concurrently by two independent LTE signals at a separation frequency of around 60 MHz, in the presence of in-phase/quadrature (I/Q) modulator imperfections. The measurement results validate the accurate linearization performance of the proposed model in suppressing the adjacent channel power (ACP) , as well as the QM impairments, as compared to other state-of-the-art models.
A New Pentafluorothio-Substituted Curcuminoid with Superior Antitumor Activity (2021)

A new and readily available pentafluorothiophenyl-substituted N-methyl-piperidone curcuminoid <b>1a</b> was prepared and investigated for its anti-proliferative, pro-apoptotic and cancer stem cell-differentiating activities against a panel of human tumor cell lines derived from various tumor entities. The compound <b>1a</b> was highly anti-proliferative and reached IC<sub>50</sub> values in the nanomolar concentration range. <b>1a</b> was superior to the known anti-tumorally active curcuminoid EF24 (<b>2</b>) and its known N-ethyl-piperidone analog <b>1b</b> in all tested tumor cell lines. Furthermore, <b>1a</b> induced a noticeable increase of intracellular reactive oxygen species in HT-29 colon adenocarcinoma cells, which possibly leads to a distinct increase in sub-G1 cells, as assessed by cell cycle analysis. A considerable activation of the executioner-caspases 3 and 7 as well as nuclei fragmentation, cell rounding, and membrane protrusions suggest the triggering of an apoptotic mechanism. Yet another effect was the re-organization of the actin cytoskeleton shown by the formation of stress fibers and actin aggregation. <b>1a</b> also caused cell death in the adherently cultured glioblastoma cell lines U251 and Mz54. We furthermore observed that <b>1a</b> strongly suppressed the stem cell properties of glioma stem-like cell lines including one primary line, highlighting the potential therapeutic relevance of this new compound.
Vaccine-induced spike- and nucleocapsid-specific cellular responses maintain potent cross-reactivity to SARS-CoV-2 Delta and Omicron variants (2022)

Cell-mediated immunity may contribute to providing protection against SARS-CoV-2 and its variants of concern (VOC). We developed COH04S1, a synthetic multiantigen modified vaccinia Ankara (MVA)-based COVID-19 vaccine that stimulated potent spike (S) and nucleocapsid (N) antigen-specific humoral and cellular immunity in a phase 1 clinical trial in healthy adults. Here, we show that individuals vaccinated with COH04S1 or mRNA vaccine BNT162b2 maintain robust cross-reactive cellular immunity for six or more months post-vaccination. Although neutralizing antibodies induced in COH04S1- and BNT162b2-vaccinees showed reduced activity against Delta and Omicron variants compared to ancestral SARS-CoV-2, S-specific T cells elicited in both COH04S1- and BNT162b2-vaccinees and N-specific T cells elicited in COH04S1-vaccinees demonstrated potent and equivalent cross-reactivity against ancestral SARS-CoV-2 and the major VOC. These results suggest that vaccine-induced T cells to S and N antigens may constitute a critical second line of defense to provide long-term protection against SARS-CoV-2 VOC.
Resource driven synthesis in the HYPER system (2002)

A global optimization strategy for design synthesis is presented. This strategy, which drives the transformation, allocation, assignment, and scheduling phases of the synthesis process, uses a resource utilization table to estimate the quality of the solution and to select the next step to be taken. The technique is implemented in the HYPER system, a synthesis environment targeted at high-performance real-time systems. The effectiveness of the techniques is demonstrated with a number of examples.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Figure S4 from Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis (2023)

&lt;p&gt;Supplementary Figure S4. Images of lung parenchyma invaded by both orange (CCT54-treated) cells and green (vehicle -treated) cells.&lt;/p&gt;
Contribution à l'étude du système quinaire Ca++NH4+H+NO3−PO4H2O. III. Le système quaternaire Ca++NH4+H+NO3−H2O à 25° (1951)

Abstract Nous avons établi pour 25° le diagramme de solubilité du système quaternaire Ca ++ NH 4 + H + NO 3 − H 2 O.
Rotating and semi-stationary multi-beamline architecture study for cardiac CT imaging (2014)

Over the past decade, there has been abundant research on future cardiac CT architectures and corresponding reconstruction algorithms. Multiple cardiac CT concepts have been published, including third-generation single-source CT with wide-cone coverage, dual-source CT, and electron-beam CT, etc. In this paper, we apply a Radon space analysis method to two multi-beamline architectures: triple-source CT and semi-stationary ring-source CT. In our studies, we have considered more than thirty cardiac CT architectures and triple-source CT was identified as a promising solution, offering approximately a three-fold advantage in temporal resolution, which can significantly reduce motion artifacts due to the moving heart and lungs. In this work, we describe a triple-source CT architecture with all three beamlines (i.e. source-detector pairs) limited to the cardiac field of view in order to eliminate the radiation dose outside the cardiac region. We also demonstrate the capability of performing full field of view imaging when desired, by shifting the detectors. Ring-source dual-rotating-detector CT is another architecture of interest, which offers the opportunity to provide high temporal resolution using a full-ring stationary source. With this semi-stationary architecture, we found that the azimuthal blur effect can be greater than in a fully-rotating CT system. We therefore propose novel scanning modes to reduce the azimuthal blur in ring-source rotating detector CT. Radon space analysis method proves to be a useful method in CT system architecture study.
The Role of the Paraventricular System in the Pathogenesis of Cyclic Vomiting (1995)

The Johns Hopkins University and Hospital, Baltimore, Maryland, U.S.A. Address correspondence and reprint requests to Dr. P. J. Pasrichaat Gastroenterology Division, The Johns Hopkins Hospital,Blalock 943. 600 N. Wolfe St., Baltimore, MD 21287-4461,U.S.A.
<title>Three-dimensional reconstruction from incomplete Fourier spectra: an extrapolation approach</title> (1996)

3D reconstruction from an incomplete data set is an ill- posed problem. To overcome this drawback, an approach based on constrained optimization is introduced. This approach provides a powerful mathematical framework for selecting a specific solution from the set of feasible solutions; this is done by minimizing some criteria depending on prior densitometric information. We propose a global optimization scheme using a deterministic relaxation algorithm based on Bregman's algorithm associated with half-quadratic minimization techniques. When used for 3D vascular reconstruction from 2D digital subtracted angiography data, such an approach allows reconstructing well-contrasted 3D vascular network in comparison with results obtained by using standard algorithms.
Expanding the Diversity of Imaging-Based RNAi Screen Applications Using Cell Spot Microarrays (2013)

Over the past decade, great strides have been made in identifying gene aberrations and deregulated pathways that are associated with specific disease states. These association studies guide experimental studies aimed at identifying the aberrant genes and networks that cause the disease states. This requires functional manipulation of these genes and networks in laboratory models of normal and diseased cells. One approach is to assess molecular and biological responses to high-throughput RNA interference (RNAi)-induced gene knockdown. These responses can be revealed by immunofluorescent staining for a molecular or cellular process of interest and quantified using fluorescence image analysis. These applications are typically performed in multiwell format, but are limited by high reagent costs and long plate processing times. These limitations can be mitigated by analyzing cells grown in cell spot microarray (CSMA) format. CSMAs are produced by growing cells on small (~200 mm diameter) spots with each spot carrying an siRNA with transfection reagent. The spacing between spots is only a few hundred micrometers, thus thousands of cell spots can be arranged on a single cell culture surface. These high-density cell cultures can be immunofluorescently stained with minimal reagent consumption and analyzed quickly using automated fluorescence microscopy platforms. This review covers basic aspects of imaging-based CSMA technology, describes a wide range of immunofluorescence assays that have already been implemented successfully for CSMA screening and suggests future directions for advanced RNAi screening experiments.
In Vivo Imaging of Pressure Effects in Normal Breast Tissue with Quantitative Multi-Spectral Near-Infrared Tomography (2004)

Near-infrared tomographic images of choromphores and scatterers have been validated with phantoms and used in imaging pressure effects in normal breast tissue. Dominant changes occur in water content and scattering power under applied external pressure.
The intermediate service platform architecture for home networking services (2010)

This paper introduces an intermediate service platform architecture for home network services. The platform is composed of two layered platforms: the home network management platform and the service management platform. The former provides the common functions necessary for all home network services, while the latter provides the corresponding functions necessary for specific services. The functions enable both users and service providers to enjoy or provide many kinds of home network services flexibly. We use the platform to implement various service applications in an experimental house, and assess the validity of the platform through its operation.
Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors (2018)

Sarcomas are cancers of the bone and soft tissue often defined by gene fusions. Ewing sarcoma involves fusions between <i>EWSR1</i>, a gene encoding an RNA binding protein, and E26 transformation-specific (ETS) transcription factors. We explored how and when <i>EWSR1-ETS</i> fusions arise by studying the whole genomes of Ewing sarcomas. In 52 of 124 (42%) of tumors, the fusion gene arises by a sudden burst of complex, loop-like rearrangements, a process called chromoplexy, rather than by simple reciprocal translocations. These loops always contained the disease-defining fusion at the center, but they disrupted multiple additional genes. The loops occurred preferentially in early replicating and transcriptionally active genomic regions. Similar loops forming canonical fusions were found in three other sarcoma types. Chromoplexy-generated fusions appear to be associated with an aggressive form of Ewing sarcoma. These loops arise early, giving rise to both primary and relapse Ewing sarcoma tumors, which can continue to evolve in parallel.
Supplementary Figure 1 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq (2023)

Supplementary Figure 1 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
P‐205L: Late‐News Poster : Improvement of Viewing Angle Dependence and Out‐Coupling Efficiency of OLEDs with Strong Microcavity Structure by Introduction of Nanoporous Polymer Films (2016)

To improve a viewing angle characteristic as well as a light extraction effect, we fabricated nanoporous polymer film (NPF) as a scattering medium as well as a light extraction component. We designed two types of organic light emitting diodes (OLEDs) with strong microcavity effect containing two different hole transport layer (HTL) thickness (e.g. 30 nm and 60 nm) to investigate each optical behavior of NPF. Very interestingly, we could observe a significant enhancement of external quantum efficiency (EQE) for each device [30 nm thick HTL : 18.0 %, 60nm thick HTL : 31.6 %] when we attached 125 um thick PET film coated with NPF. Furthermore, NPF successfully suppress the viewing angle dependence to realize ideal angular emission even though it's somehow different from that of Lambertian distribution.
Correlation of L-myc Genotypes to Metastasis of Gastric Cancer and Breast Cancer (1990)

Journal Article Correlation of L-myc Genotypes to Metastasis of Gastric Cancer and Breast Cancer Get access KANJI ISHIZAK, KANJI ISHIZAK * Radiation Biology CenterJapan Correspondence to : Radiation Biology Center, Kyoto University, Yoshida-Jonoecho, Sakyo-Ku, Kyoto 606, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar MITSUO KATO, MITSUO KATO Radiation Biology CenterJapan Search for other works by this author on: Oxford Academic PubMed Google Scholar MITSUO IKENAGA, MITSUO IKENAGA Radiation Biology CenterJapan Search for other works by this author on: Oxford Academic PubMed Google Scholar KAZUO HONDA, KAZUO HONDA Second Department of Surgery Faculty of MedicineJapan Search for other works by this author on: Oxford Academic PubMed Google Scholar KAZUE OZAWA, KAZUE OZAWA Second Department of Surgery Faculty of MedicineJapan Search for other works by this author on: Oxford Academic PubMed Google Scholar JUNYA TOGUCHIDA JUNYA TOGUCHIDA Department of Orthopaedic Surgery Faculty of Medicine Kyoto University KyotoJapan Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 3, 7 February 1990, Pages 238–239, https://doi.org/10.1093/jnci/82.3.238 Published: 07 February 1990
Building a Better Mouse: Genetically Altered Mice as Models for Gene Therapy (2000)

This chapter covers: Producing mouse models of human disease Mouse models for gene therapy Models of monogenetic disease vs polygenetic disorders Models for therapeutics Chimeric animal models Xenografts in animal models
Genotype I of Japanese Encephalitis Virus Virus-like Particles Elicit Sterilizing Immunity against Genotype I and III Viral Challenge in Swine (2018)

Swine are a critical amplifying host involved in human Japanese encephalitis (JE) outbreaks. Cross-genotypic immunogenicity and sterile protection are important for the current genotype III (GIII) virus-derived vaccines in swine, especially now that emerging genotype I (GI) JE virus (JEV) has replaced GIII virus as the dominant strain. Herein, we aimed to develop a system to generate GI JEV virus-like particles (VLPs) and evaluate the immunogenicity and protection of the GI vaccine candidate in mice and specific pathogen-free swine. A CHO-heparan sulfate-deficient (CHO-HS(-)) cell clone, named 51-10 clone, stably expressing GI-JEV VLP was selected and continually secreted GI VLPs without signs of cell fusion. 51-10 VLPs formed a homogeneously empty-particle morphology and exhibited similar antigenic activity as GI virus. GI VLP-immunized mice showed balanced cross-neutralizing antibody titers against GI to GIV viruses (50% focus-reduction micro-neutralization assay titers 71 to 240) as well as potent protection against GI or GIII virus infection. GI VLP-immunized swine challenged with GI or GIII viruses showed no fever, viremia, or viral RNA in tonsils, lymph nodes, and brains as compared with phosphate buffered saline-immunized swine. We thus conclude GI VLPs can provide sterile protection against GI and GIII viruses in swine.
The cost of helical CT lung cancer screening is high (2003)

▴ Mahadevia PJ, Fleisher LA, Frick KD, et al . Lung cancer screening with helical computed tomography in older adult smokers: a decision and cost-effectiveness analysis. JAMA2003;289:313–22 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] In this study a computer simulated model of a hypothetical cohort of 100 000 60 year old current, quitting, and former smokers was used to assess the cost effectiveness of helical CT lung cancer screening. Using the best available data on outcomes associated with lung cancer screening, the costs of diagnosis, treatment … [1]: {openurl}?query=rft.jtitle%253DJAMA%26rft.stitle%253DJAMA%26rft.issn%253D0002-9955%26rft.aulast%253DMahadevia%26rft.auinit1%253DP.%2BJ.%26rft.volume%253D289%26rft.issue%253D3%26rft.spage%253D313%26rft.epage%253D322%26rft.atitle%253DLung%2BCancer%2BScreening%2BWith%2BHelical%2BComputed%2BTomography%2Bin%2BOlder%2BAdult%2BSmokers%253A%2BA%2BDecision%2Band%2BCost-effectiveness%2BAnalysis%26rft_id%253Dinfo%253Adoi%252F10.1001%252Fjama.289.3.313%26rft_id%253Dinfo%253Apmid%252F12525232%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1001/jama.289.3.313&link_type=DOI [3]: /lookup/external-ref?access_num=12525232&link_type=MED&atom=%2Fthoraxjnl%2F58%2F4%2F298.atom [4]: /lookup/external-ref?access_num=000180345100026&link_type=ISI
Pediatric‐inspired therapy compared to allografting for Philadelphia chromosome‐negative adult ALL in first complete remission (2015)

For adults with Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL) in first complete remission (CR1), allogeneic hematopoietic cell transplantation (HCT) is an established curative strategy. However, pediatric-inspired chemotherapy may also offer durable leukemia-free survival in the absence of HCT. We compared 422 HCT recipients aged 18-50 years with Ph-ALL in CR1 reported to the CIBMTR with an age-matched concurrent cohort of 108 Ph- ALL CR1 patients who received a Dana-Farber Consortium pediatric-inspired non-HCT regimen. At 4 years of follow-up, incidence of relapse after HCT was 24% (95% CI 19-28) versus 23% (95% CI 15-32) for the non-HCT (chemo) cohort (P=0.97). Treatment-related mortality (TRM) was higher in the HCT cohort [HCT 37% (95% CI 31-42) versus chemo 6% (95% CI 3-12), P<0.0001]. DFS in the HCT cohort was 40% (95% CI 35-45) versus 71% (95% CI 60-79) for chemo, P<0.0001. Similarly, OS favored chemo [HCT 45% (95% CI 40-50)] versus chemo 73% [(95% CI 63-81), P<0.0001]. In multivariable analysis, the sole factor predictive of shorter OS was the administration of HCT [hazard ratio 3.12 (1.99-4.90), P<0.0001]. For younger adults with Ph- ALL, pediatric-inspired chemotherapy had lower TRM, no increase in relapse, and superior overall survival compared to HCT. Am. J. Hematol. 91:322-329, 2016. © 2015 Wiley Periodicals, Inc.
Next generation wireless systems using Markov decision process model (2005)

A Markov Decision Process Model Based Handoff Management algorithm using interference control for next generation wireless systems (NGWS) was developed. This research is an extension of [1], which considers the different parameters of wireless networks, like power consumption, bandwidth, signaling, and switching and rerouting to make a handoff decision. We consider Signal-to-Interference ratio [4] as one more important parameter in wireless networks.
Calorimetric study of the order‐disorder conformational transition in succinoglycan (1996)

Thermally induced order-disorder conformational transition in succinoglycan was studied using the method of high-sensitivity differential scanning microcalorimetry within the range of polysaccharide concentrations from 0.1 to 3.5 mg mL−1 at NaCl concentrations 0, 0.01, and 0.1M. The positions and shapes of the excess heat capacity curves depended substantially on both the NaCl and polysaccharide concentrations. At low polysaccharide concentrations in salt-free solution the experimental curves were closely approximated by the two-state model suggesting the transition mechanism to be of the single helix-coil type. With increasing polysaccharide and/or NaCl concentration, the experimental curves changed significantly in symmetry, which indicated a changing transition mechanism. At high polysaccharide concentrations or in the presence of the salt, the order-disorder transition of succinoglycan was shown to include two stages: the cooperative dissociation of the helix dimer and subsequent two-state melting of the helix monomer. The dependence of thermodynamic parameters for the dissociation and melting of helix structures in succinoglycan on NaCl and polysaccharide concentrations was obtained by fitting the experimental excess heat capacity curves. The cooperativity parameter σ for the single helix-coil transition as well as the average length of the helix segment of succinoglycan were calculated. Some features of succinoglycan ordering in solution are discussed. © 1996 John Wiley & Sons, Inc.
Tandem Mass Spectrometry in the Detection of Inborn Errors of Metabolism for Newborn Screening (2007)

Tandem mass spectrometry has been used for determinations of enzyme activities in biological samples. Activities in rehydrated dried blood spots of lysosomal enzymes glucocerebrosidase, acid sphingomyelinase, galactocerebroside beta-galactosidase, acid-alpha-galactosidase, acid alpha-glucosidase, and alpha-D-iduronidase are measured simultaneously by multiple-reaction monitoring of ion dissociations from cations produced by electrospray ionization of enzymatic products. Simple and inexpensive assay protocols are described that are readily adopted for handling multiple samples in 96-well microtiter plates, employing simple separation steps, and using less than or equal to 3 micromol of synthetic or commercially available substrates, and less than 25 nmol of internal standards per analysis. The assays have the potential of being used for large-scale screening of newborns for the detection of inborn errors of metabolism.
(Invited) Heteroepitaxial Lattice Mismatch Stress Relaxation in Nonpolar and Semipolar GaN by Dislocation Glide (2013)

Lattice mismatch stresses in heteroepitaxial (In,Al,Ga)N structures based on nonpolar and semipolar orientations of GaN can result in relaxation via dislocation glide as a result of shear stresses on inclined slip planes, with important consequences for optoelectronic device design.
Demonstration of β-(AlxGa1−x)2O3/β-Ga2O3modulation doped field-effect transistors with Ge as dopant grown via plasma-assisted molecular beam epitaxy (2017)

β-(AlxGa1−x)2O3/β-Ga2O3 heterostructures were grown via plasma-assisted molecular beam epitaxy. The β-(AlxGa1−x)2O3 barrier was partially doped by Ge to achieve a two-dimensional electron gas (2DEG) in Ga2O3. The formation of the 2DEG was confirmed by capacitance–voltage measurements. The impact of Ga-polishing on both the surface morphology and the reduction of the unintentionally incorporated Si at the growth interface was investigated using atomic force microscopy and secondary-ion mass spectrometry. Modulation doped field-effect transistors were fabricated. A maximum current density of 20 mA/mm with a pinch-off voltage of −6 V was achieved on a sample with a 2DEG sheet charge density of 1.2 × 1013 cm−2.