gebhart/patrepeval huggingface dataset:
Trimming of microring resonators by photo-oxidation of a plasma-polymerized organosilane cladding material (2005)

As the complexity of microphotonic devices grows, the ability to precisely trim microring resonators becomes increasingly important. Photo-oxidation trimming uses UV irradiation to oxidize a cladding layer composed of polymerized hexamethyldisilane (6M2S) deposited with plasma-enhanced chemical vapor deposition (PECVD). PECVD 6M2S has optical properties that are compatible with microring devices, and its high cross linking renders it insoluble. Photo-oxidation decreases the refractive index of PECVD 6M2S by nearly 4%, permitting large resonance shifts that are not feasible with thermal trimming techniques. Resonance shifts from single-mode, 100? ? ??m diameter Si3N4(n=2.2) rings were as large as 12.8?nm for the TE mode and 23.5?nm for the TM mode.
THE ROLE OF HISTONE DEACETYLASE 6 (HDAC6) IN MUTANT GLYCYL-TRNA SYNTHETASE (GARS) AND MUTANT SMALL HEAT SHOCK PROTEIN B1 (HSPB1)-INDUCED AXONAL CHARCOT-MARIE-TOOTH DISEASE (CMT) (2016)

Reference EPFL-CONF-222115View record in Web of Science Record created on 2016-10-18, modified on 2017-05-25
Validation of a method of estimating age, modelling growth, and describing the age composition of Coilia mystus from the Yangtze Estuary, China (2008)

Abstract He, W., Li, Z., Liu, J., Li, Y., Murphy, B. R., and Xie, S. 2008. Validation of a method of estimating age, modelling growth, and describing the age composition of Coilia mystus from the Yangtze Estuary, China. – ICES Journal of Marine Science, 65: 1655–1661. A collection of 577 Coilia mystus was made during April 2006 and 2007 from China’s Yangtze Estuary to estimate the age structure and growth patterns of the population. Examination of sectioned sagittal otoliths revealed a periodic straight/curved growth pattern. The straight zone was from April to November, and the curved zone from October to May, indicating annual periodicity. Annual periodicity was also verified by margin zone analysis. The shift from a curved-zone to the next straight-zone stanza was defined as an annulus. The fish from which the otoliths were taken were 0–5 years old. The von Bertalanffy growth function was fitted to standard length (LS)-at-age data as LS = 215.16 (1 – e−0.53 (t+ 0.30)) (n = 577, r2 = 0.81, p &lt; 0.05). The mature females included five age classes, ages 1 and 2 accounting for 74.3% of the population. The mature males included fish aged 1 and 2, those at age 1 accounting for 86.4% of the population. Mean length was smaller, and annual growth less, for mature males than for females of comparable age. The study demonstrated that the Yangtze population of C. mystus consists of more age classes than previously thought and that the age structure of the population needs to be considered in management decisions.
Cardiovascular responses to graded reductions in hindlimb perfusion in exercising dogs (1983)

In six dogs trained to run at 2, 4, and 6 mph, we caused graded reductions in hindlimb perfusion by compressing the terminal aorta. Our goal was to examine the relationship between hindlimb perfusion [terminal aortic flow (TAQ) and femoral arterial pressure (FP)] and cardiovascular responses [aortic pressure (AP), heart rate, and ascending aortic flow (CO)]. Small reductions in TAQ and FP produced bradycardia, small decreases in CO, and small increases in AP. Further reductions in TAQ and FP produced tachycardia, increased CO, and large increases in AP. AP rose by about 1 mmHg for each 1-mmHg fall in FP. The response was similar at all speeds, but as work load increased it required smaller reductions in FP and TAQ to cause a pressor response (e.g., at 6 mph we could not demonstrate a nonlinear relationship between TAQ and AP). At low work loads the cardiovascular responses to exercise were most likely set by signals other than feedback from exercising muscle because substantial reductions in hindlimb perfusion caused no significant cardiovascular responses. At moderate-to-high work loads or where muscle perfusion is restricted, metabolic feedback from muscle may play a role in cardiovascular responses to exercise.
Effect of oligosaccharides supplementation on the meat performance traits and selected indicators of humoral immunity in lambs. (2010)

The experiment was performed on 32 suckling Kamieniec lambs divided into two equal groups: I – control and II – experimental. Over a period of 60 d, experimental lambs were fed a diet supplemented with Saccharomyces cerevisiae yeast with an increased β-1,3/1,6-D-glucan and mannan-oligosaccharide content. The following meat performance parameters were determined: body weight, daily gains, growth rate, the dimensions of musculus longissimus dorsi sections, skin and subcutaneous fat thickness, and fat thickness over the loin „eye” area. Serum humoral immunity parameters: lysozyme and ceruloplasmin activities, total protein, and γ-globulin contents were determined. The yeast supplement significantly increased the values of the analysed meat performance traits. As regards the investigated humoral immunity parameters, i.e. lysozyme activity, ceruloplasmin activity (throughout the entire experiment), and γ-globulin content (from experimental day 30 to 60), significantly higher values were noted in the experimental group, compared with the control group. Statistically significant differences between the compared groups were not observed only with respect to total protein content.
INL Review of Fueling Machine Inspection Tool Development Proposal (2015)

A review of a technical proposal for James Fischer Nuclear. The document describes an inspection tool to examine the graphite moderator in an AGR reactor. The system is an optical system to look at the graphite blocks for cracks. INL reviews the document for technical value.
Abstract 3479: CPX-351 (cytarabine:daunorubicin liposome for injection) anti-leukemia activity is potentiated by Chk1 inhibition (2015)

Abstract Background: Cytarabine and an anthracycline, the mainstay of AML therapy, affords a five-year survival below 30%. Accordingly, there is a continuing need for improved AML therapies. CPX-351 encapsulates within liposomes a fixed 5:1 molar ratio of cytarabine and daunorubicin that is synergistic (in vitro) and markedly improved in anti-leukemic activity (in vivo). Promising evidence of improved remission and survival rates with CPX-351 compared to standard of care treatments has also been observed clinically and a pivotal Phase 3 trial is currently ongoing. Because Chk1 inhibition has been shown to enhance the actions of both cytarabine and anthracyclines, there has been interest in assessing the effect of CPX-351 when combined with Chk1 inhibitors. Here we describe the evaluation of CPX-351 alone and in combination with the Chk1 inhibitors MK-8776 and LY2603618 in AML cell lines and in clinical AML samples ex vivo. Methods: Effects of CPX-351 on Chk1 phosphorylation and cell cycle distribution in the human AML lines U937 and HL-60 were analyzed by immunoblotting and flow cytometry. Effects of Chk1 inhibitors on CPX-351-induced apoptosis were assessed by flow cytometry after propidium iodide staining (DNA cleavage), Hoechst staining (nuclear fragmentation) and colony formation in soft agar (long-term survival). Effects CPX-351 ± MK-8776 on clinical AML samples were assayed using clonogenic assays. Results: Treatment of U937 cells with CPX-351 resulted in phosphorylation of Chk1 on Ser317 and Ser296 (sites of ATR-mediated phosphorylation and autophosphorylation, respectively) as well as S phase slowing consistent with Chk1 activation. Co-treatment of AML cell lines with Chk1 inhibitors + CPX-351 resulted in increased apoptotic morphological changes and DNA fragmentation as well as diminished clonogenic survival compared to CPX-351 alone. The CPX-351/MK-8776 combination displayed enhanced antiproliferative effects against some clinical AML isolates ex vivo compared to CPX-351 alone, with additional assays ongoing. Conclusions: Collectively, these results show that Chk1 inhibition enhances the cytotoxicity of CPX-351 in AML cell lines and some clinical AML samples, offering the possibility that CPX-351 may be well suited for combining with such molecularly targeted agents. Citation Format: Nicole D. Vincelette, Larry M. Karnitz, Judith E. Karp, Douglas B. Smith, Allan D. Hess, Lawrence D. Mayer, Scott H. Kaufmann. CPX-351 (cytarabine:daunorubicin liposome for injection) anti-leukemia activity is potentiated by Chk1 inhibition. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3479. doi:10.1158/1538-7445.AM2015-3479
Human Breast Milk miRNA, Maternal Probiotic Supplementation and Atopic Dermatitis in Offspring (2015)

ClinicalTrials.gov NCT00159523.
Titanium oxide films on Si(100) deposited by e-beam evaporation (2000)

Titanium oxide films with a thickness of a 400 nm were deposited on p-type Si(100) at room temperature by e-beam evaporation, and titanium dioxide was evaporated in oxygen environment at a pressure of 2×10−6–4×10−5 Torr. Effects of oxygen flow rate (FO2) on the properties of the films, such as surface roughness, composition, and chemical states, have been investigated. The root-mean-square surface roughness of the films increased with increasing FO2 up to 20 sccm, and then decreased over 20 sccm. X-ray diffraction patterns show that the titanium oxide films are amorphous. Oxygen resonance backscattering spectroscopy shows that all films are oxygen rich, i.e., relative atomic ratio (CO/CTi) of the films ranged from 2.05 to 2.25. But the x-ray photoelectron spectroscopy (XPS) analysis shows that the titanium oxide films were oxygen deficient. The ratio of oxygen to titanium (CO2/CTi) of the films calculated by XPS ranged from 1.82 to 1.93. XPS shows that there exist only Ti3+ and Ti4+ charge states in the film. Ti4+ states of the films are nearly constant at 0.47 up to O2 flow rate of 20 sccm, and then slightly increase with increasing O2 flow rate. Although rutile TiO2 is used as a starting material, titanium K-edge x-ray absorption near-edge spectroscopy (XANES) spectra show that the structure of the TiO2−x films grown in oxygen environment are amorphous. The Ti K-edge XANES spectra from the films is the same regardless of FO2.
COTS Fusion Tracker Evaluation (2002)

Lincoln Laboratory was tasked by the FAA to measure the performance of a representative sample of current commercial off-the-shelf (COTS) fusion trackers. This effort included cataloging the companies that have available ATC fusion trackers, acquiring executable tracker images from as many as possible of these trackers, running the commercial tracker code on the test sets, and evaluating the performance achieved. This report presents an overall review of the state-of-the-art of fusion trackers as applied to the FAA surveillance problem. Average statistics of performance, as well as performance in special situations, are included. In each case, the performance of fusion is compared against the performance of single sensor and mosaiced tracking. Thus, the advantages and disadvantages of fusion will be evident. The statistics may also permit the generation of a fusion tracker specification should the FAA decide to procure one as part of a future automation system.
MicroRNAs in Human Cancers (2017)

This chapter focuses on microRNAs (miRNAs), which are the smallest member among all known non-coding RNAs (ncRNAs). MiRNA coding genes are located either within the introns or exons of protein-coding genes or in intergenic areas, and mostly found to be evolutionarily conserved. Biogenesis of miRNAs involves multistep processes that can be divided into transcription, nuclear cropping, export to the cytoplasm, and cytoplasmic dicing. Like a protein-coding gene, a miRNA can act as a tumor suppressor when its loss of function is related to malignant transformation of a normal cell. The loss of function of a miRNA can be a result of genomic deletion, mutation, epigenetic silencing, and/or miRNA processing alterations. Overall frequency of Single Polymorphism (SNP) in miRNA-binding site or SNP in miRNA sequences was predicted to be less than 1%, due to the size of miRNA and its binding site. In 2003, stem cell-specific miRNA signature was first described in mouse embryonic stem cells.
Hemicarceplex (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Stereoselective synthesis and structure of butalactin and lactone II isolated from Streptomyces species (2004)

Butalactin (1a) and lactone II (2a) have been synthesized starting from (S)-malic acid and sorbic acid by a straightforward route. The absolute stereochemistry of 1a and 2a was unambiguously established by this synthesis.
Supplementary Figure 2 from Lymphatic Zip Codes in Premalignant Lesions and Tumors (2023)

Supplementary Figure 2 from Lymphatic Zip Codes in Premalignant Lesions and Tumors
Saliency Maps for Point Clouds (2020)

Algorithms for creating saliency maps are well established for images, even though there is no literature on such methods for point clouds. We use orthographic projections in 2D planes which are subject to well established saliency detection algorithms to create a 3D saliency map. The results of each saliency map are projected to the 3D voxels and the results of the many projections are used to generate a 3D saliency map. Simple compression tests were carried using soft region-of-interest maps. Results have shown an increase in the quality of the voxels inside the selective regions of increased levels of interest.
ChemInform Abstract: Synthesis, Computer Modeling and Biological Evaluation of Novel Protein Kinase C Agonists Based on a 7‐Membered Lactam Moiety. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A new route for the synthesis of nitrides: The solvothermal preparation of GaN (2000)

Abstract A new solvothermal route for the synthesis of nitrides is proposed using liquid NH3 as solvent in supercritical conditions, Such a preparation method was applied to the synthesis of GaN using gallium metal as starting material. GaN is a wide band-gap semi-conductor (3.4eV). It is a very attractive nitride due to its various applications in micro- and opto-electronics [1,2]. Consequently, many research groups are interested in synthesising GaN. Two methods have been principally developed: (i) synthesis of thin films by epitaxy [3,4] (ii) synthesis of bulk GaN by high pressure method [5,6]. The new proposed process leads to fine microcrystallites of GaN with the wurtzite-type structure. The chemical purity can be optimised versus the synthesis mechanism. The size and shape of the crystallites would be influenced by the nature of the nitriding additive and the thermodynamical conditions (pressure and temperature) used for the synthesis. Key Words: High pressureGaNsolvothermal preparation
Supplementary Figure Legends 1-5, Table Legend 1 from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency (2023)

&lt;p&gt;PDF file - 100K&lt;/p&gt;
FeFe ‐Hydrogenase Assembly (2017)

Abstract Hydrogenases are a class of enzymes involved in the conversion of dihydrogen into protons and electrons and the reverse reaction, reduction of protons into hydrogen. The reaction takes place at a unique 6Fe‐metallocenter, named the H cluster. It consists of a classical [4Fe–4S] cluster and a unique [2Fe] subcluster linked to each other via a cysteine bridge. Maturation of [FeFe]‐hydrogenases involves the synthesis of the ligands of the [2Fe] subcluster, namely CO, CN − , and azapropanedithiolate (adt 2− ), and the assembly of the [2Fe] subcluster, depending on the concerted action of three metalloproteins, HydE, HydF, and HydG. HydE and HydG are “radical SAM” enzymes involved in the synthesis of the ligands. HydF functions as a scaffold protein in which a precursor of the [2Fe] subcluster is assembled before being transferred to the hydrogenase. An original chemical approach for the maturation of [FeFe]‐hydrogenases has been recently developed: a small synthetic complex, [Fe 2 (adt)(CO) 4 (CN) 2 ] 2− , mimicking the hydrogenase active site, can transform an inactive hydrogenase, lacking the [2Fe] subcluster, into a fully active enzyme, with no need for the HydEFG maturation machinery. Here, we review the current knowledge regarding the structure and the function of the three maturases and the assembly of the [2Fe] subcluster of [FeFe]‐hydrogenases via natural and chemical maturation.
ChemInform Abstract: Silicon‐Directed Nazarov Cyclizations. Part 4. Stereochemical Control. (1986)

Abstract The influence of substituents on the stereochemical outcome of the title reaction is studied.
Dynamic Contrast-Enhanced MRI–Derived Intracellular Water Lifetime (τi): A Prognostic Marker for Patients with Head and Neck Squamous Cell Carcinomas (2017)

A combined analysis of mean intracellular water molecule lifetime and volume transfer constant provided the best model to predict overall survival in patients with squamous cell carcinomas of the head and neck.
Factors Affecting the Loss of Carbon Monoxide from Stored Blood Samples* (1986)

The loss of carbon monoxide (CO) from whole blood or hemolysates has been investigated. Blood samples were exposed to the atmosphere or to a limited volume of air for various storage periods at three temperatures. The initial hemoglobin (Hb) concentration and the percent carboxyhemoglobin (%COHb) saturation were varied in separate experiments. In addition, the effect of repeated exposure of blood to air was evaluated. The %COHb saturation decreased from 80 to 50% following storage of a 1-mL blood sample with 49 mL of air in a sealed container at room temperature for 45 hr. Greater decreases in the %COHb saturation were observed in samples which were exposed to the atmosphere. Lesser, but significant, losses occurred when samples were stored in a refrigerator or freezer. The concentration of Hb in the samples as well as the initial %COHb saturation were found to influence the decrease in the %COHb saturation.
Shape deformation in ion beam irradiated colloidal monolayers: An AFM investigation (2020)

Self-assembly of colloidal monolayers represents a prominent approach to the fabrication of nanostructures. The modification of the shape of colloidal particles is essential in order to enrich the variety of attainable patterns which would be limited by the typical assembly of spherical particles in a hexagonal arrangement. Polymer particles are particularly promising in this sense. In this article, we investigate the deformation of closely-packed polystyrene particles under MeV oxygen ion irradiation at normal incidence using atomic force microscopy (AFM). By developing a procedure based on the fitting of particle topography with quadrics, we reveal a scenario of deformation more complex than the one observed in previous studies for silica particles, where several phenomena, including ion hammering, sputtering, chemical modifications, can intervene in determining the final shape due to the specific irradiation conditions. In particular, deformation into an ellipsoidal shape is accompanied by shrinkage and polymer redistribution with the presence of necks between particles for increasing ion fluence. In addition to casting light on particle irradiation in a regime not yet explored, we present an effective method for the characterization of the colloidal particle morphology which can be applied to describe and understand particle deformation in other regimes of irradiation or with different techniques.
Deciphering the role of mucosal immune responses and cervicovaginal microbiome in resistance to HIV infection in HIV-exposed seronegative (HESN) women (2021)

Abstract The female genital tract (FGT) is an essential site of HIV infection. Discerning the nature of HIV-specific local immune responses is crucial for identifying correlates of protection in HIV-exposed seronegative (HESN) individuals. The present study involved a comprehensive analysis of soluble immune mediators, secretory immunoglobulins (sIg) and levels of natural killer (NK) cells, CXCR5 + CD8 + T cells, T follicular helper cells (Tfh) and T regulatory cells (T regs) in the vaginal mucosa, as well as the nature and composition of the cervicovaginal microbiome in HESN women. We found significantly elevated antiviral cytokines, soluble immunoglobulins, and increased frequencies of activated NK cells, CXCR5 + CD8 + T cells and Tfh cells in HESN females as compared to HIV unexposed healthy (UH) women. Analysis of the genital microbiome of HESN women revealed a greater bacterial diversity and increased abundance of Gardnerella spp in the mucosa of HESN women. The findings suggest the female genital tract of HESN females represents a microenvironment equipped with innate immune factors, antiviral mediators and critical T cells subsets that protect against HIV infection.
0 to 10k in 20 Seconds: Bootstrapping Large-Scale DHT Networks (2011)

A handful of proposals address the problem of bootstrapping a large DHT network from scratch, but they all forgo the standard DHT join protocols in favor of their own distributed algorithms that build routing tables directly. Motivating their algorithms, the proposals make a perfunctory claim that the standard join protocols are not designed to handle the huge number of concurrent join requests involved in such a bootstrapping scenario. Moreover, the proposals assume a pre-existing unstructured overlay as a starting point for their algorithms. We find the assumption somewhat unrealistic. We take a step back and reexamine the performance of the standard DHT join protocols. Starting with nothing other than a well-known bootstrap server, when faced with a large number of nodes joining nearly simultaneously, can the standard join algorithms form a stable DHT overlay? If so, how quickly? Our simulation results show that Chord and Kademlia's join protocols can actually handle the bootstrapping scenario quite well. For 10,000 nodes joining at a rate of 1,000 nodes per second, Chord and Kademlia took less than 20 and 15 seconds, respectively, to form a stable overlay. The Chord join protocol, however, requires a slight modification for fast bootstrapping. We elucidate the reason why the modification is necessary.
Protein excretion and renal adaptation of transgenic mRen2 rats to changing oral sodium loads (1993)

Chung, Oliver; Schips, Thomas; Rohmeiss, Peter; Gretz, Norbert; Strauch, Manfred; Linger, Thomas Author Information