gebhart/patrepeval huggingface dataset:
Planar Nanostrip-Channel Al2O3/InAlN/GaN MISHEMTs on Si With Improved Linearity (2018)

In this work, a 100 nm-gate Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> /InAlN/GaN metal-insulator-semiconductor high electron mobility transistor (MISHEMT) with a planar nanostrip-channel was fabricated on a Si substrate and its DC, small-signal RF and two-tone intermodulation characteristics were measured. The use of a planar nanostrip-channel and MIS structure allows these devices to have close to 10 dB better intermodulation distortion than traditional InAlN/GaN high electron mobility transistors. In addition, the GaN planar nanostrip-channel MISHEMT shows five orders of magnitude lower gate current I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> , 30% higher current drivability and much improved g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> and f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> gate voltage swing than a planar nanostrip-channel GaN HEMT with a Schottky gate. This allows the planar nanostrip-channel GaN MISHEMT to be able to operate at higher input gate voltage (more than V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> = +4 V) and achieve higher output current with better linearity performance.
Personalizing Localized Prostate Cancer: Validation of a Combined Clinical Cell-cycle Risk (CCR) Score Threshold for Prognosticating Benefit From Multimodality Therapy (2021)

Patients with CCR scores below the multimodality threshold (2.112) may safely forgo multimodality therapy. The CCR score can be used as a decision aid to counsel men whether or not single-modality therapy would be sufficient for their intermediate- or high-risk prostate cancer.
On the characterization of voltage and current transducers in steady‐state distorted conditions (2001)

Abstract The traceability of measurements performed to gauge information about the operation of electrical power systems under nonsinusoidal conditions is an important and live issue, usually neglected by the technical Standards. A generalized definition of the “composite error” is proposed in this paper as a meaningful index for the metrological characterization of voltage and current transducers in steady‐state nonsinusoidal conditions. In this connection, the relationship among the composite error, the classical ratio and phase‐angle errors and other parameters characterizing the waveforms of the transduced quantities are pointed out. Finally, problems involved in the measurement of the composite error in steady‐state distorted conditions are dealt with and the results of some experimental work are presented.
Efficient generation of 200–230-nm radiation in beta barium borate by noncollinear sum-frequency mixing (1998)

Tunable ultraviolet radiation in the 200-230-nm region has been generated with beta barium borate crystals by type I sum-frequency mixing of the second harmonic with the fundamental beam from a dye laser pumped by the second harmonic of the same Nd:YAG laser. A noncollinear phase-matching configuration has made it possible to realize conversion efficiency of 21% at 208.3 nm with input power densities as low as 28 MW/cm(2) for the fundamental and 2.4 MW/cm(2) for its second-harmonic radiation. The absorption characteristic of a standard DNA sample has been studied with the generated tunable ultraviolet source, revealing additional features compared with those obtained with a spectrophotometer.
Supplementary Table 2 from KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells (2023)

&lt;p&gt;PDF - 68K, Normalized basal gene expression microarray data for non-squamous NSCLC NCI60 cell lines were grouped according to KRAS mutation status. Genes showing significant differences in expression between KRAS mutant and KRAS wildtype cells were analyzed using Ingenuity Pathway Analysis (IPA) and significantly different upstream regulators were predicted.&lt;/p&gt;
(Invited) Heterogeneous Integration of InP HBTs on CMOS: Leveraging and Providing Value to Conventional Silicon Technologies (2013)

Historically, compound semiconductors have enjoyed the benefit of material properties that lend themselves to high performance electron devices, but the ability to fabricate complex, high transistor count ICs is limited by the relative immaturity of the material system and small commercial market. Silicon based devices have made significant advances in device performance, but have not yet matched compound semiconductor device performance. However, a large commercial market has allowed the silicon system to mature and produce billion transistor count ICs in high volume. It would be advantageous to combine the merits of both compound semiconductors and silicon based CMOS/BiCMOS to enable a new class of high performance ICs. This work will review HRL's efforts in wafer scale integration of an advanced 250nm, 350GHz fT/fMAX InP DHBT technology with RF-CMOS technologies whose device proximity; heterogeneous interconnect density; and additional technology features both leverage and provide additional value to conventional silicon technologies.
No Strength or Gait Benefit of Two-incision THA: A Brief Followup at 1 Year (2010)

Level II, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
Abstract 337: cAbl Tyrosine Kinase Increases Catalase Activity in the Catalase-Dysregulated Newborn Rabbit Heart (2013)

Introduction: Pediatric patients undergoing corrective cardiothoracic surgery numbered in the tens of thousands annually and therefore it is necessary that pre- and post-operative strategies be employed to limit ischemia-reperfusion (IR) injury. We have found differences in the way the newborn (versus the adult) heart responds to IR injury. In the adult, catalase activity increases appropriately with increasing levels of hydrogen peroxide (H2O2), conferring cardioprotection. This effect however does not occur in the newborn. Materials and Methods: Hypoxia studies were carried out using primary cardiomyocytes from adult (&gt;8 weeks) and newborn rats. Ischemia-reperfusion (IR) studies were performed using newborn (4-5 days) rabbits. Isolated rat cardiomyocytes were exposed to 1 hour of hypoxia (95%N2,5%CO2). Immunoprecipitation and western blot analysis were done for phosphorylated and total catalase and c-Abl. In addition, catalase activity was determined spectrophotometrically by measuring the decomposition of H2O2. Newborn rabbit hearts were perfused using Langendorff method with ischemia and reperfusion periods lasting 30 and 60 minutes, respectively. DPH (200µM), a cAbl activator was injected directly into the newborn right ventricle (RV) two minutes before the reperfusion period. Results: Following hypoxia, the ratio of phosphorylated to total catalase and c-Abl in isolated newborn rat myocytes did not increase and were significantly lower (1.92- and 6.21-fold, respectively; p&lt;0.05) than their adult counterparts. Interestingly, when DPH was administered one hour prior to hypoxia, not only was catalase activity significantly increased 6.28-fold (p&lt;0.01) but phosphorylation levels were also altered. Finally, direct injection of DPH into the RV of Langendorff-perfused newborn rabbit hearts caused a significant improvement in percent recovery of developed pressure (from 49.53±5.42% to 125.5±15.5%) after IR, a key indicator of cardiac function. Catalase activity in these same hearts increased 2.92-fold. Conclusion: In the newborn, decreased phosphorylation of catalase by c-Abl potentially mediates IR-induced dysfunction. Activation of c-Abl may be a strategy to prevent ischemic injury associated with surgical procedures.
Entwicklung eines Tympanoplastik-Trainingsmodells (2007)

The experimental model can be used for demonstration and training in otosurgery. This model is also suitable for comparing measurements of transfer functions in a calibrated version and can be applied to development and critical evaluation of middle ear prostheses.
Genetic Linkage Is Excluded for the D<sub>2</sub>-Dopamine Receptor &lambda;HD2Gl and Flanking Loci on Chromosome 11q22-q23 in Tourette Syndrome (1990)

A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D2-dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to +/- 20% recombination were obtained. Overlapping regions of exclusion based upon primary map data permit exclusion of the entire region of the DRD2 locus in Tourette syndrome.
Perturbations of mesenchymal stromal cells after allogeneic hematopoietic cell transplantation predispose for bone marrow graft-versus-host-disease (2022)

Functional impairment of the bone marrow (BM) niche has been suggested as a major reason for prolonged cytopenia and secondary graft failure after allogeneic hematopoietic cell transplantation (alloHCT). Because mesenchymal stromal cells (MSCs) serve as multipotent progenitors for several niche components in the BM, they might play a key role in this process. We used collagenase digested trephine biopsies to directly quantify MSCs in 73 patients before (n = 18) and/or after alloHCT (n = 65). For the first time, we demonstrate that acute graft-versus-host disease (aGvHD, n = 39) is associated with a significant decrease in MSC numbers. MSC reduction can be observed even before the clinical onset of aGvHD (n = 10). Assessing MSCs instantly after biopsy collection revealed phenotypic and functional differences depending on the occurrence of aGvHD. These differences vanished during <i>ex vivo</i> expansion. The MSC endotypes observed revealed an enhanced population of donor-derived classical dendritic cells type 1 and alloreactive T cells as the causing agent for compartmental inflammation and MSC damage before clinical onset of aGvHD was ascertained. In conclusion, MSCs endotypes may constitute a predisposing conductor of alloreactivity after alloHCT preceding the clinical diagnosis of aGvHD.
Data from BAD, a Proapoptotic Member of the BCL2 Family, Is a Potential Therapeutic Target in Hepatocellular Carcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;Proteins of the BCL2 family are key regulators of apoptosis. Their expression levels are frequently altered in cancers, enabling tumor cells to survive. To gain insight into the pathogenesis of hepatocellular carcinoma (HCC), we performed a comprehensive survey of the expression of the members of the BCL2 family in samples obtained from surgically resected HCCs. Here, we report the occurrence of a new molecular anomaly, consisting of a strong reduction in the expression of the proapoptotic protein BAD in HCC compared with surrounding nontumoral tissue. We investigate the function of BAD in a panel of HCC cell lines. Using gene overexpression and RNA interference, we show that BAD is involved in the cytotoxic effects of sorafenib, a multikinase blocker, which is currently the sole therapeutic drug effective for the treatment of HCC. Finally, we report that ABT-737, a compound that interacts with proteins of the BCL2 family and exhibits a BAD-like reactivity, sensitizes HCC cells toward sorafenib-induced apoptosis. Collectively, our findings indicate that BAD is a key regulator of apoptosis in HCC and an important determinant of HCC cell response to sorafenib. Mol Cancer Res; 8(8); 1116–25. ©2010 AACR.&lt;/p&gt;&lt;/div&gt;
Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart (2022)

These results uncover a new mechanism of ischemic injury in which ARRDC4 drives glucose deprivation-induced endoplasmic reticulum stress leading to cardiomyocyte death. Our findings establish ARRDC4 as a new scaffold protein for GLUT1 that regulates cardiac metabolism in response to ischemia and provide insight into the therapeutic strategy for ischemic heart disease.
Development and characterisation of a 3D technology including TSV and Cu pillars for high frequency applications (2010)

As 3D packaging technologies are becoming more and more present in packaging roadmap, applications with higher requirement are rising continuously. Today, one of the main applications requiring 3D technologies is dedicated to nomadic components, including mobile phones, due to their very high compacity and integration capabilities. Those components need to work at high frequency, typically up to 1 GHz. For these frequencies, the resistance and the capacitance of the interconnections have to be minimized, in order to decrease the signal delay. This is a real challenge for 3D integration and especially for post process through silicon vias. In the first part of the paper, a study and a simple model to determine the main parameters responsible for resistance and parasitic capacitance variation will be presented. Then, a technical focus will be done on the improvement of the TSV electrical performances, especially the decreasing of the TSV parasitic capacitance from 2.41 pF to 0.76 pF based on Plasma Enhanced Chemical Vapour Deposition (PECVD) process development. Finally, the integration of this new material on a technological test vehicle with electrical results will be presented and discussed.
Single mode fibers with antireflective surface structures for high power laser applications (2014)

We present results for increased transmission of ~99.5% in the near-IR through the end faces of silica single mode fibers by creating a random antireflective microstructure etched into the end face of the fiber. We demonstrate high laser damage thresholds for these fibers with AR structured surfaces.
THE MINI-POSTERIOR APPROACH: EVIDENCE OVER EMINENCE – AFFIRMS (2018)

The position of this surgeon is that there is no approach that provides superior outcomes for total hip replacement (THR). The direct anterior approach (DAA) has become popular with patients becaus...
Fascia Lata in Penile Reconstructive Surgery: A Reappraisal of the Fascia Lata Graft (1997)

Various surgical techniques and innovations have been applied to manage complex penile deformities. As an adjunct to penile reconstructive surgery, use of fascia lata, the superficial connective tissue structure of the thigh, may also be considered. Herein, four case reports are described in which fascia lata was applied: penile deformity associated with multiple unsuccessful penile prosthesis surgeries; penile prosthesis migration after phalloplasty; partial penile loss after ablative penile cancer surgery; and penile fibromatosis (Peyronie's disease). Fascia lata was autogenously obtained from the lateral thigh in all cases and used for, respectively, corporoplasty, penile prosthesis fixation, penile elongation, and tunica albuginea grafting. Surgeries were successful in every instance, and each patient reported satisfactory neophallic appearance and function postoperatively. The functional anatomy of the fascia lata was investigated further with lower extremity cadaveric dissections. For penile reconstructive surgery, fascia lata offers an autogenous source, it can be expeditiously obtained causing minimal morbidity, and it serves as a viable graft material with good tensile strength. Its application derives from, and may extend to, other reconstructive surgeries.
Anisotropic Molecular Orientation of Poly(o-trimethylsilyl)-Phenylacetylene Film Swollen under High Magnetic Field (1994)

Poly(o-trimethylsllyl)-phenylacetylene (PTP) film, which was swollen in acetone under a high magnetic field of 15 T, showed birefringence and dichroism. Comparing the IR dichroism of magnetic-field-treated film with that of mechanically stretched film, it was found that the polymer long chain was aligned perpendicularly to the magnetic field. This alignment originated from the magnetic anisotropy of crystalline structures in PTP film.
Progress in developing a combined x-ray CT and SPECT system using CdZnTe detector (1999)

A medical imaging system providing both x-ray transmission and radionuclide measurements would allow correlation of structural and functional information. We therefore are evaluating a pixellated CdZnTe detector for combined x-ray CT and SPECT imaging with various readout electronics. Gamma-ray spectra of <SUP>57</SUP>Co measured using NIM electronics (2-microsecond(s) shaping time) and multichannel fast photon-counting electronics (50-ns shaping time) produced energy resolutions of 6.5 keV FWHM and 17 keV FWHM respectively at 122 keV. Fast photon-counting electronics achieved linear x-ray count-rate response up to 4 X 10<SUP>5</SUP> cps. Dual-mode digital readout electronics are described, which promise to improve SPECT and x-ray CT performance in comparison to the fast-counting electronics. The leakage current and x-ray response with the dual-mode electronics are studied. The leakage current as small as tens of pA is measured, while detector current over 5 orders of magnitude is measured with linearity over 4 orders of magnitude. Results suggest that the CdZnTe detector is capable of performing both x-ray CT and SPECT with the fast photon-counting electronics, and the digital readout electronics can improve the x-ray CT performance.
Investigation of azimuthal staging concepts in annular gas turbines (2011)

In this work, the influence of azimuthal staging concepts on the thermoacoustic behavior of annular combustion chambers is assessed theoretically and numerically. Staging is a well-known and effective method to abate thermoacoustic pulsations in combustion chambers. However, in the case of, for example, fuel staging the associated inhomogeneity of equivalence ratio may result in increased levels of NOx emissions. In order to minimize this unwanted effect a staging concept is required in which the transfer functions of the burners are changed while affecting the equivalence ratio as little as possible. In order to achieve this goal, a theoretical framework for predicting the influence of staging concepts on pulsations has been developed. Both linear and nonlinear analytical approaches are presented and it is shown that the dynamics of azimuthal modes can be described by coupled Van der Pol oscillators. A criterion based on the thermoacoustic coupling strength and on the asymmetry degree provides the modal behavior in the annular combustor, i.e. standing or traveling waves. The model predictions have been verified by numerical simulations of a heavy-duty gas turbine using an in-house thermoacoustic network-modeling tool. The interaction between the heat release of the flame and the acoustic field was modeled using measured transfer functions and source terms. These numerical simulations confirmed the original theoretical considerations.
Inhibitory effects on the production of inflammatory mediators and reactive oxygen species by Mori folium in lipopolysaccharide-stimulated macrophages and zebrafish (2017)

Mori folium, the leaf of Morus alba L. (Moraceae), has been traditionally used for various medicinal purposes from ancient times to the present. In this study, we examined the effects of water extract of Mori folium (WEMF) on the production of inflammatory mediators, such as nitric oxide (NO) and prostaglandin E2 (PGE2), and reactive oxygen species (ROS) in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophages. Our data indicated that WEMF significantly suppressed the secretion of NO and PGE2 in RAW 264.7 macrophages without any significant cytotoxicity. The protective effects were accompanied by a marked reduction in their regulatory gene expression at the transcription level. WEMF attenuated LPS-induced intracellular ROS production in RAW 264.7 macrophages. It inhibited the nuclear translocation of the nuclear factor-kappa B p65 subunit and the activation of mitogen-activated protein kinases in LPS-treated RAW 264.7 macrophages. Furthermore, WEMF reduced LPS-induced NO production and ROS accumulation in zebrafish. Although more efforts are needed to fully understand the critical role of WEMF in the inhibition of inflammation, the findings of the present study may provide insights into the approaches for Mori folium as a potential therapeutic agent for inflammatory and antioxidant disorders.
Energy migration within hexameric hemoprotein reconstituted with Zn porphyrinoid molecules (2015)

Photosensitizers, Zn protoporphyrin IX and Zn chlorin e6, are completely inserted into each heme pocket of a hexameric apohemoprotein. The fluorescence quenching efficiencies upon addition of methyl viologen are 2.3 and 2.6 fold-higher than those of the partially photosensitizer-inserted proteins, respectively, indicating that the energy migration occurs within the proteins.
Mast cell binding of neurotensin. II. Molecular conformation of neurotensin involved in the stereospecific binding to mast cell receptor sites. (1977)

Systematic substitution of the natural L-amino acids in neurotensin by their D isomers reveals that the COOH-terminal portion of this tridecapeptide is required for binding to mast cell receptors: D-amino acid replacements from Pro10 through Leu13 substantially decrease that binding. Either blockage of the COOH-terminal carboxyl group as with N-methylamidation, or formation of a cyclic structure by the inclusion of a disulfide bond, a Cys2,13 substitution, markedly reduces the specific binding to mast cell receptor sites. Modifications in the NH2-terminal portion of neurotensin do not affect the binding to mast cells. However, D-Arg8 and D-Arg9 substitutions increase binding by factors of 5- to 6-fold. The hydroxyl group at position 3 or 11 is not essential for binding since Phe3 or Phe11 is equivalent to Tyr3 or Tyr11. The COOH-terminal penta- and hexapeptides are able to displace approximately 70% 125I-neurotensin relative to the intact peptide. Of 18 other biologically active peptides tested, only xenopsin, a naturally occurring COOH-terminal analog of neurotensin, and bradykinin effectively compete in the binding assay to an extent of 60 and 100%, respectively. Histamine, diphenhydramine, and noradrenaline are ineffective in this regard.
On the Impact of Mobility on the Channel Estimation in WIMAX OFDMA-Uplink (2006)

The demand for wireless broadband access systems supporting mobility of the individual users has dramatically increased in recent years. To this end, we analyze the impact of user-mobility in the uplink of an OFDMA system on the performance of pilot-aided channel estimation. We analyze the mean square error (MSE) performance of two pilot-aided channel estimation schemes, the simple Gauss-Markov estimator and the optimal LMMSE estimator. We derive closed-form expressions for the MSE taking into account the impact of intercarrier-interference and time-variations of the channel. Different pilot allocation strategies are analyzed and their performances are compared. Finally, the results are illustrated by numerical simulations based on the WiMax 802.16e specifications