gebhart/patrepeval huggingface dataset:
Trial in progress: Open-label, randomized, comparative phase 2/3 study of combination immunotherapy plus standard-of-care chemotherapy and SBRT versus standard-of-care chemotherapy for the treatment of locally advanced or metastatic pancreatic cancer. (2021)

TPS4174 Background: Pancreatic cancer will claim an estimated 47,050 lives in the USA in 2020, with an expected 5 year survival of 10%. Thus there is an urgent need for novel treatment options in this disease. We hypothesize that effective response against pancreatic cancer requires a coordinated approach that orchestrates both the innate and adaptive immune system. We further hypothesize that by orchestrating the activation of the entire immune system, we could accomplish immunogenic cell death with durable responses in this disease. We describe a novel combination immunotherapy protocol of low-dose chemoradiation, cytokine-induced NK and T cell activation via N-803 (an IL-15 cytokine fusion protein), and off-the-shelf PDL1-targeted high-affinity NK cell (PDL1 t-haNK) infusion. Methods: The ongoing QUILT 88 phase II/III, multi-center, three-cohort, open-label, US study (NCT04390399) to evaluate the comparative efficacy and overall safety of standard-of-care chemotherapy versus standard-of-care chemotherapy in combination with aldoxorubicin HCl, N-803, and PD-L1 t-haNK in subjects with locally advanced or metastatic pancreatic cancer. Each treatment setting (ie, first line maintenance, second line, or third line or greater) will be evaluated independently as a separate cohort. Subjects with locally advanced or metastatic pancreatic cancer who have received at least 16 weeks of treatment with gemcitabine plus nab-paclitaxel, and have had either a partial response (PR), CR, or stable disease (SD), will be enrolled into Cohort A to receive first-line maintenance therapy. Subjects who have disease progression on or after receiving first-line treatment with gemcitabine plus nab-paclitaxel or another first-line chemotherapy regimen (eg, FOLFIRINOX), or who have discontinued first-line treatment (eg, due to toxicity or intolerance) will be enrolled into Cohort B to receive second-line therapy randomized to irinotecan-liposome/5FU/LV versus experimental arm. Subjects who have disease progression after receiving at least 2 lines of therapy for pancreatic cancer, will be enrolled into Cohort C to receive third-line or greater treatment. Primary endpoints by cohort are: A) PFS per RECIST V1., B &amp; C) OS. The secondary endpoints include overall response rate, DoR, DCR, OS(cohort A) and QoL by patient-reported outcomes. Clinical trial information: NCT04390399.
Kinetic Energy Release Distribution (KERD) (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Reflections on "African Voices" at the Smithsonian's National Museum of Natural History (2001)

Mary Jo Arnoldi, Christine Mullen Kreamer, Michael Atwood Mason, Reflections on "African Voices" at the Smithsonian's National Museum of Natural History, African Arts, Vol. 34, No. 2 (Summer, 2001), pp. 16-35+94
Extreme light infrastructure: laser architecture and major challenges (2010)

Extreme Light Infrastructure (ELI), the first research facility hosting an exawatt class laser will be built with a joint international effort and form an integrated infrastructure comprised at last three branches: Attosecond Science (in Szeged, Hungary) designed to make temporal investigation at the attosecond scale of electron dynamics in atoms, molecules, plasmas and solids. High Field Science will be mainly focused on producing ultra intense and ultra short sources of electons, protons and ions, coherent and high energetic X rays (in Prague, Czech Republic) as well as laserbased nuclear physics (in Magurele, Romania). The location of the fourth pillar devoted to Extreme Field Science, which will explore laser-matter interaction up to the non linear QED limit including the investigation of vacuum structure and pair creation, will be decided after 2012. The research activities will be based on an incremental development of the light sources starting from the current high intensity lasers (APOLLON, GEMINI, Vulcan and PFS) as prototypes to achieve unprecedented peak power performance, from tens of petawatt up to a fraction of exawatt (10<sup>18</sup> W). This last step will depend on the laser technology development in the above three sites as well as in current high intensity laser facilities.
Compatibility of Chlorinated Polyolefin with the Components of Thermoplastic Polyolefin:  A Study by Laser Scanning Confocal Fluorescence Microscopy (2004)

Dye-labeled samples of a chlorinated (21.8 wt % Cl), maleated polypropylene (CPO), and a dye-labeled sample of poly(ethylene-co-butene) (EBR28, with 28 wt % butene) were synthesized and characterized. The dye was a functional benzothioxanthene related to the commercial dye Hostasol Yellow 3G. These substances were introduced as tracers into blends of CPO with polypropylene (PP) and with EBR9 (9 wt % butene) as well as ternary blends of CPO + PP + EBR9. The morphology of the blends was examined by laser scanning confocal fluorescence microscopy. Control experiments at 5 wt % tracer showed that the dye-labeled CPO was fully miscible with its unlabeled precursor and that dye-labeled EBR28 was fully miscible with pure EBR9. The blend experiments showed that this particular CPO was much more miscible with EBR9 than with PP. Ternary blend experiments intended to mimic the composition of a thermoplastic polyolefin (TPO, with 25% EBR9 as the impact modifier) showed that the EBR formed micron size droplets in the PP matrix and that the CPO completely engulfed the EBR droplets to form a core−shell morphology. Center cross sections of these droplets showed the CPO layer to be uniform in thickness, with a sharp interface with the PP matrix. The inner interface, between the CPO and EBR, was noticeably broader, with a thickness on the order of 0.5 μm, indicating only weak segregation between these two components of the blend.
ChemInform Abstract: Peptide‐Based Tachykinin NK2 Receptor Antagonists (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Direct calculation of Maxwell stress tensor for accurate trajectory prediction during DEP for 2D and 3D structures (2006)

It is known that careful engineering of dielectrophoresis (DEP) forces can be strong enough to move microparticles towards regions of higher or lower field strength. While many of the microdevices exploit differing electrical properties between cells to enact separation, the use of DEP as a generic electrical technique to position and move cells is still under investigation. Our work focuses on developing a robust numerical tool based on calculation of the Maxwell stress tensor (MST) both in a 2D and in a 3D formulation that aims towards providing a deeper understanding of cells interaction using DEP as a handle to position and manipulate cells for fundamental cell biology. The complex Laplace equation is first solved to obtain a value for the potential everywhere on the structure under investigation. The electric field is then obtained by a simple finite difference approach and the time-averaged DEP force exerted on a cell immersed in a medium with complex permittivity and subject to a sinusoidal electric field is calculated using the MST technique. MST is compared with a more approximate method and the ability of the approach to model a cell trajectory from a random initial point within the vicinity of an electrode system, in addition to cell–cell interaction, is also demonstrated.
Processes in electronic commerce (2003)

Trading communities, virtual business processes and virtual enterprises are key elements in today's electronic commerce. We argue that supporting these notions is similar to supporting the development of coarse grained distributed programs and that these programs can be abstracted as processes. Following this idea, we have developed a language for the enactment of processes that incorporates several important features like exception handling, event management and transactional guarantees. We describe these features and discuss the use of processes in E-Comm.
FlashNet (2017)

During the past decade, network and storage devices have undergone rapid performance improvements, delivering ultra-low latency and several Gbps of bandwidth. Nevertheless, current network and storage stacks fail to deliver this hardware performance to the applications, often due to the loss of IO efficiency from stalled CPU performance. While many efforts attempt to address this issue solely on either the network or the storage stack, achieving high-performance for networked-storage applications requires a holistic approach that considers both.
Utilization of Ni as a Non-Noble-Metal Co-catalyst for Ceria-Supported Rhenium Oxide in Combination of Deoxydehydration and Hydrogenation of Vicinal Diols (2022)

Removal of vicinal diols by combination of deoxydehydration and hydrogenation (DODH + HG) was carried out over the mixture of ReOx/CeO2 and CeO2-supported base metals with H2 as the reducing agent, in order to replace expensive Pd in the ReOx–Pd/CeO2 catalyst used in previous studies for the same reaction. Similar high activity and selectivity of the mixture catalysts of ReOx/CeO2 and pre-reduced Ni/CeO2 were observed for DODH + HG as those of Pd-based catalysts (co-loaded ReOx–Pd/CeO2 or mixture catalysts of ReOx/CeO2 + Pd/CeO2), while co-loaded ReOx–Ni/CeO2 catalyst showed almost no activity. The ReOx/CeO2 + Ni/CeO2 catalyst system gave 99% yield of tetrahydrofuran from 1,4-anhydroerythritol and could be applied to DODH + HG of other diols and polyols such as glycerol, erythritol, and xylitol. Unlike ReOx–Pd/CeO2, the activity of the ReOx/CeO2 + Ni/CeO2 catalyst decreased in the reuse test, especially before second or later reuses, even when the recovered catalyst was calcined as regeneration. The catalysts were characterized by various methods such as thermal gravimetry–differential thermal analysis, temperature-programmed reduction with H2, and X-ray absorption fine structure spectroscopy. The deactivated ReOx/CeO2 + Ni/CeO2 catalyst after use and the inactive ReOx–Ni/CeO2 catalyst after reduction had Re–Ni direct bonds, suggesting that the strong interaction between Re and Ni species decreased the activity of ReOx/CeO2 in the DODH reaction.
Effect of Bulk-filling on the Bonding Efficacy in Occlusal Class I Cavities. (2016)

Both the configuration factor and the type of bulk-fill composite were found to have a great impact on bonding to cavity-bottom dentin.
VITRECTOMY FOR PROLIFERATIVE DIABETIC RETINOPATHY WITH ASTEROID HYALOSIS (1998)

In vitrectomy for PDR with asteroid hyalosis, and in cases of simple vitreous hemorrhage, surgery should be performed with full understanding of the anatomic characteristics. Notably, if posterior vitreous detachment is not present, the occurrence of iatrogenic retinal breaks is more likely.
Structure of 2-(α-hydroxybenzyl)-8-methyl-8-azabicyclo[3.2.1]octan-3-one (1993)

The unambiguous structure of the title compound (which was formed in the reaction of the lithium enolate of tropinone with benzaldehyde) has been determined to be the exo-anti diastereoisomer. The piperidine ring adopts a flattened-chair conformation with the carbonyl group pushed away from the ethylene bridge. There is an intermolecular hydrogen bond between the hydroxyl group and the N atom which replaces the intramolecular O-H...N hydrogen bond indicated by solution NMR data
Faculty Opinions recommendation of NikR-operator complex structure and the mechanism of repressor activation by metal ions. (2006)

Metal ion homeostasis is critical to the survival of all cells. Regulation of nickel concentrations in Escherichia coli is mediated by the NikR repressor via nickel-induced transcriptional repression of the nickel ABC-type transporter, NikABCDE. Here, we report two crystal structures of nickel-activated E. coli NikR, the isolated repressor at 2.1 A resolution and in a complex with its operator DNA sequence from the nik promoter at 3.1 A resolution. Along with the previously published structure of apo-NikR, these structures allow us to evaluate functional proposals for how metal ions activate NikR, delineate the drastic conformational changes required for operator recognition, and describe the formation of a second metal-binding site in the presence of DNA. They also provide a rare set of structural views of a ligand-responsive transcription factor in the unbound, ligand-induced, and DNA-bound states, establishing a model system for the study of ligand-mediated effects on transcription factor function. PMID: 16945905 Funding information This work was supported by: NIGMS NIH HHS, United States Grant ID: GM69857 NIGMS NIH HHS, United States Grant ID: R01 GM069857
Tail asymptotics for policies favoring short jobs in a many-flows regime (2006)

Scheduling policies that prioritize short jobs have received growing attention in recent years. The class of SMART policies includes many such disciplines, e.g. Shortest-Remaining-Processing-Time (SRPT) and Preemptive-Shortest-Job-First (PSJF). In this work, we study the delay distribution of SMART policies and contrast this distribution with that of the Least-Attained-Service (LAS) policy, which indirectly favors short jobs by prioritizing jobs with the least attained service (age).We study the delay distribution (rate function) of LAS and the SMART class in a discrete-time queueing system under the many sources regime. Our analysis in this regime (large capacity and large number of flows) hinges on a novel two dimensional queue representation, which creates tie-break rules. These additional rules do not alter the policies, but greatly simplify their analysis. We demonstrate that the queue evolution of all the above policies can be described under this single two dimensional framework.We prove that all SMART policies have the same delay distribution as SRPT and illustrate the improvements SMART policies make over First-Come-First-Served (FCFS). Furthermore, we show that the delay distribution of SMART policies stochastically improves upon the delay distribution of LAS. However, the delay distribution under LAS is not too bad -- the distribution of delay under LAS for most jobs sizes still provides improvement over FCFS. Our results are complementary to prior work that studies delay-tail behavior in the large buffer regime under a single flow.
Organolanthanide-Catalyzed Synthesis of Amine-Capped Polyethylenes (2007)

The chain transfer agent dicyclohexylamine is introduced into organolanthanide-mediated ethylene polymerizations to produce amine-terminated polyethylenes. The resulting polymers were characterized by 1H and 13C NMR, GPC, and DSC. Good polymerization activities (up to 104 g polymer/(mol Ln·atm ethylene·h)) and narrow polydispersities are observed in the polymerization/chain transfer process. Dicyclohexylamine-capped polyethylene product molecular weights are found to be inversely proportional to dicyclohexylamine concentration, supporting an amine chain transfer mechanism. The present study represents the first efficient catalytic method for introducing electron-rich amine groups into otherwise inert polyolefins.
Inhibited Autoxidation of Polypropylene (1978)

For di-tert-butyl peroxide-initiated oxidations in benzene solution at 120°C, singly hindered phenols appear to have twice the chain-stopping power of the di-tert-butylphenols; e.g., a given molar quantity of 2-tert-butyl-4-methylphenol will give twice the inhibition period of 2,6-di-tert-butyl-4-methylphenol. The stoichiometry of the polypropylene peroxy radicals reacting with 2,6-di-tert-butyl-4-alkylphenols is independent of their attachment in large molecules; all of the phenolic residues in these polyfunctional molecules were utilized in stopping oxidation chains. Although inhibition periods in polypropylene oxidations are proportional to the inhibitor concentration, the overall kinetics of the inhibited oxidations are complex. Attempts to demonstrate the superiority of singly hindered phenols in oven-aging tests were only partially successful.
Responses to “Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study”: authors’ reply (2020)

sponsorship: All the operational phase of this study (patient recruitment, data collection, and statistical analysis) was funded by Tilman SA. (Tilman SA)
Novel Flexible Sulfur Wire Fabrics (FSF) for Lithium-Sulfur Batteries (2015)

Introduction Lithium sulfur and lithium-air batteries hold much promise for the future of batteries on account of their theoretical capacities of 2567 and 3505 Wh/kg respectively(1). The dissolution of sulfur through the formation of soluble polysulfides and the poor electronic conductivity of sulfur are however, major problems hindering Li-S battery progress (1-3). In addition, particle fracture and delamination as a result of repeated volumetric expansion and contraction have also been identified as factors responsible for poor long term performance(4, 5). In our previous work on lithium-sulfur batteries, we have shown the effectiveness of using a thin Li-ion conducting barrier layer in improving the cycling characteristics(6). In this work, we develop a unique strategy to directly prepare sulfur wire mattes ( Figure 1 ) capable of being spun as yarn and thereupon being used directly in the form of ‘textile fabric batteries’. Using these wires, we generate two other morphologies to specifically tackle fade and conductivity issues existing in sulfur cathodes. This results in sulfur cathodes with high electronic conductivity, minimal volumetric expansion and improved rate capabilities and cyclability. In addition, the electrodes that we use in this study allow us to obtain high areal capacities. Figure 1 shows SEM and EDAX map of the same. Results of these studies will be presented and discussed. Captions Figure 1: (a) Scanning electron microscopy image of the sulfur wires (b) EDAX map indicating the Sulfur distribution. References 1. P. G. Bruce, S. A. Freunberger, L. J. Hardwick and J.-M. Tarascon, Nature Materials , 11 , 19 (2012). 2. J. Cabana, L. Monconduit, D. Larcher and M. Rosa Palacin, Advanced Materials , 22 , E170 (2010). 3. B. Scrosati and J. Garche, Journal of Power Sources , 195 , 2419 (2010). 4. L. Ji, M. Rao, S. Aloni, L. Wang, E. J. Cairns and Y. Zhang, Energy &amp; Environmental Science , 4 , 5053 (2011). 5. Z. Wei Seh, W. Li, J. J. Cha, G. Zheng, Y. Yang, M. T. McDowell, P.-C. Hsu and Y. Cui, Nat Commun , 4 , 1331 (2013). 6. P. J. Hanumantha, B. Gattu, O. Velikokhatnyi, M. K. Datta, S. S. Damle and P. N. Kumta, Journal of The Electrochemical Society , 161 , A1173 (2014). Figure 1
Multiple magnetic phases ofLa2CoMnO6−δ(0<~δ<~0.05) (2003)

Transport and magnetic properties of polycrystalline ${\mathrm{La}}_{2}{\mathrm{CoMnO}}_{6\ensuremath{-}\ensuremath{\delta}},$ $0&lt;~\ensuremath{\delta}&lt;~0.05,$ have revealed the existence of two distinguishable monoclinic ferromagnetic phases separated by a two-phase domain $0.02&lt;~\ensuremath{\delta}&lt;~0.05$ and a pseudotetragonal $(c/a&lt;\sqrt{2})$ phase with $\ensuremath{\delta}&gt;~0.05$ that was prepared at 600 \ifmmode^\circ\else\textdegree\fi{}C. A nearly oxygen-stoichiometric sample having a magnetization $M(5\mathrm{K},50\mathrm{kOe})=5.78{\ensuremath{\mu}}_{B}/\mathrm{f}.\mathrm{u}.$ with a Curie temperature ${T}_{c}\ensuremath{\approx}226\mathrm{K}$ is identified as atomically ordered ${\mathrm{La}}_{2}{\mathrm{Co}}^{2+}{\mathrm{Mn}}^{4+}{\mathrm{O}}_{6}$ containing about 1.8% antiferromagnetic spins at antisites. This ferromagnetic phase is an n-type polaronic conductor that progressively traps mobile electrons at the oxygen vacancies that introduced them on lowering the temperature. Although the x-ray-diffraction pattern can be indexed in orthorhombic (Pbnm) or monoclinic ${(P2}_{1}/n)$ symmetry with $\ensuremath{\beta}\ensuremath{\approx}90\ifmmode^\circ\else\textdegree\fi{},$ atomic order identifies the space group as ${P2}_{1}/n.$ A second monoclinic, ferromagnetic phase with ${T}_{c}&lt;150\mathrm{K}$ and $\ensuremath{\delta}\ensuremath{\approx}0.05$ has a large, positive thermoelectric power that increases progressively with decreasing temperature. Quenching a $\ensuremath{\delta}\ensuremath{\approx}0.02$ sample from 1350 \ifmmode^\circ\else\textdegree\fi{}C into liquid ${\mathrm{N}}_{2}$ gave a single phase with ${T}_{c}=134\mathrm{K}$ and $\ensuremath{\delta}\ensuremath{\approx}0.05.$ A sample with $\ensuremath{\delta}&gt;~0.05$ that was synthesized at 600 \ifmmode^\circ\else\textdegree\fi{}C was pseudotetragonal $(c/a&lt;\sqrt{2})$ and had a paramagnetic Weiss constant $\ensuremath{\theta}&lt;{T}_{c}\ensuremath{\approx}225\mathrm{K}$ as well as a significantly smaller magnetization, but its magnetization curve $M(T)$ showed no evidence of spin-glass behavior; its large, positive thermoelectric power was characteristic of polaronic conduction without trapping of mobile charge carriers at lower temperatures. Interpretation of the two phases with $\ensuremath{\delta}\ensuremath{\approx}0.05$ is based on the hypothesis that introduction of high-spin ${\mathrm{Mn}}^{3+}$ by the oxygen vacancies creates around it additional ${\mathrm{Mn}}^{3+}$ and intermediate-spin ${\mathrm{Co}}^{3+}$ at neighboring sites; the resulting gain in elastic energy from cooperative, dynamic Jahn-Teller deformations at these ions must be sufficient to overcome the cost of about 0.2 eV for the electron transfer from a ${\mathrm{Co}}^{2+}\mathrm{ion}$ to a ${\mathrm{Mn}}^{4+}\mathrm{ion}.$
Cyclopentadienyl titanium hydroxylaminato complexes as highly active catalysts for the polymerization of propylene (2005)

Half sandwich complexes of titanium bearing eta1 or eta2 bound nitroxide ligands are highly active catalysts for the polymerisation of propylene to high molecular weight atactic poly(propylene).