gebhart/patrepeval huggingface dataset:
Cocaine Decreases Cortical Cerebral Blood Flow but Does Not Obscure Regional Activation in Functional Magnetic Resonance Imaging in Human Subjects (1998)

The authors used functional magnetic resonance imaging (fMRI) to determine whether acute intravenous (i.v.) cocaine use would change global cerebral blood flow (CBF) or visual stimulation-induced functional activation. They used flow-sensitive alternating inversion recovery (FAIR) scan sequences to measure CBF and blood oxygen level-dependent (BOLD) sensitive T2* scan sequences during visual stimulation to measure neuronal activation before and after cocaine and saline infusions. Cocaine (0.6 mg/kg i.v. over 30 seconds) increased heart rate and mean blood pressure and decreased end tidal carbon dioxide (CO2). All measures returned to baseline by 2 hours, the interinfusion interval, and were unchanged by saline. Flow-sensitive alternating inversion recovery imaging demonstrated that cortical gray matter CBF was unchanged after saline infusion (-2.4 +/- 6.5%) but decreased (-14.1 +/- 8.5%) after cocaine infusion (n = 8, P < 0.01). No decreases were detected in white matter, nor were changes found comparing BOLD signal intensity in cortical gray matter immediately before cocaine infusion with that measured 10 minutes after infusion. Visual stimulation resulted in comparable BOLD signal increases in visual cortex in all conditions (before and after cocaine and saline infusion). Despite a small (14%) but significant decrease in global cortical gray matter CBF after acute cocaine infusion, specific regional increases in BOLD imaging, mediated by neurons, can be measured reliably.
MP92-13 NOVEL COMBINATION TREATMENT (OGX427/ SORAFENIB) ENHANCES SENSITIVITY IN RENAL CELL CARCINOMA (2016)

be solved. We show that the autocrine secretion of IL-6 induced by TKIs-stimulation causes activation of AKT-mTOR pathway, and also show that combination therapy with IL-6 receptor antibody and TKI reduces angiogenesis and GLUT1 expression.
Electronic Pre-Compensation for a 10.7-Gb/s System Employing a Directly Modulated Laser (2011)

We investigate electronic pre-compensation for a 10.7-Gb/s system employing a directly modulated laser (DML). Initially, the nonlinear distortion resulting from the direct modulation of the laser is mitigated by pre-compensation based on reversal of the large signal rate equations and the use of digital signal processing to generate an appropriate modulating current. This concept is then utilized in a novel look-up table optimization scheme for electronic dispersion pre-compensation. Simulation results show pre-compensation of up to 350 km of single mode fiber at a required optical signal to noise ratio <; 16 dB for a bit error rate of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> . It is shown that a 42.8 GSa/s digital to analog converter is sufficient for exploiting the full potential for electronic pre-compensation using a DML.
Predictors of Abdominal Aortic Aneurysm Sac Enlargement After Endovascular Repair (2011)

In this multicenter observational study, compliance with EVAR device guidelines was low and post-EVAR aneurysm sac enlargement was high, raising concern for long-term risk of aneurysm rupture.
Optimal Protection from Impact, Shock and Vibration (2001)

Systems that provide protection from impact, shock and vibration are held up by sophisticated physical principles. In this volume, the author explores those principles in a straightforward manner. All aspects of the theory of optimal isolation are presented, from a description of the systems that use these principles to the design of such systems a
Development of a multi-pathogen enrichment broth for simultaneous growth of five common foodborne pathogens (2015)

The objective of the present study was to formulate a multi-pathogen enrichment broth which could support the simultaneous growth of five common foodborne pathogens (Salmonella enterica, Staphylococcus aureus, Shigella flexneri, Listeria monocytogenes and Escherichia coli O157:H7). The formulated broth SSSLE was composed of potassium tellurite, bile salt, lithium chloride, and sodium chloride as growth-inhibitors; glucose, esculin, mannitol and sodium pyruvate as growth-promoters. Compared with the respective specific selective enrichment broths, the individual growth pattern of each target pathogen in SSSLE was equal, or even better, except in the case of S. flexneri. In mixed-culture experiments, the gram-negative bacteria showed higher growth capabilities than the gram-positive bacteria after 8-h enrichment; however, the cell numbers after 24-h enrichment indicated that SSSLE could support the concurrent growth of five target pathogens irrespective of whether pathogens were inoculated initially at equal or unequal levels. For natural food samples under the high background flora, the final cell numbers enriched in SSSLE for five targets were enough to be detected by multiplex PCR. In conclusion, SSSLE was capable of supporting the growth of five target pathogens concurrently. The new broth formulated in this study has the potential of saving time, efforts and costs in multi-pathogen enrichment procedures.
Assisted Single-Step Acid Pretreatment Process for Enhanced Delignification of Rice Straw for Bioethanol Production (2018)

Dilute acid pretreatment of lignocellulosic biomass at higher temperatures (>160 °C) solubilizes/removes hemicelluloses (xylan, arabinan, mannan, galactan) and acid-soluble lignin (ASL), but, it does not remove acid-insoluble lignin (AIL). During acid pretreatment, the condensation and redeposition of coalesced lignin over cellulose fibers reduces the access of cellulose to cellulases. For higher delignification, various multistage pretreatments are available, however, all these are energy/chemical intensive methods. Therefore, an effective pretreatment which provides increased cellulose accessibility by enhanced removal of hemicelluloses and lignin in a single-step would be preferred. Our investigation reports a novel assisted single-step acid pretreatment (ASAP) process for enhanced delignification of biomass under acidic conditions. Pretreatment of rice straw (particle size of 20 mm) with H2SO4 (0.75% v/v) + boric acid (1% w/v) + glycerol (0.5% v/v) (solid/liquid (S/L), 1:5) at 150 °C for 20 min removed hemicelluloses completely, 44% of the lignin, and ∼48.5% of the silica leaving a solid consisting of 69 ± 1.5% glucan, 0.7 ± 0.06% ASL, 20 ± 2.0% AIL, and 12 ± 1.5% silica. The C/L (cellulose/lignin) ratio of solids resulted from ASAP was found to be > 3.00, while it was < 2.00 for acid only and untreated solids. Enzymatic hydrolysis of ASAP treated biomass with enzyme loadings of 20 FPU g–1 at 15% (w/v) solids concentration gave about 72% glucan conversion to glucose. This amount of glucose was around 2.6 times higher than obtained with enzymatic hydrolysis of acid-only-pretreated solids and 4.2 times higher than untreated rice straw (control). Therefore, the assisted-acid pretreatment dramatically enhanced delignification of rice straw and thereby glucan-to-glucose conversion.
Memory‐Enhancing Drugs (2000)

Abstract Whereas memory enhancement can be viewed as generally beneficial to many individuals, agents being developed are almost exclusively for some form of impairment. The memory‐enhancing drugs therapeutically available offer only symptomatic relief rather than slowing or stopping the progression of dementia. The greatest effort in development has been in the areas of cerebral metabolism and neurotransmission enhancers. Cerebral vasodilators and nootropics have both been developed for usage, as have cholinergic enhancers.
Autoimmune Hemolytic Anemia Accompanied by Reactivation of an Epstein-Barr Virus Infection with Suppressed CTL Response to EBV-infected Cells in an Elderly Man (2010)

An 88-year-old man with autoimmune hemolytic anemia (AIHA) who had been treated with low dose prednisolone developed a sudden worsening of his anemia accompanied by reactivation of Epstein-Barr virus (EBV). We established EBV-infected spontaneous lymphoblastoid cell lines (LCL), performed an enzyme-linked immunosorbent spot assay, and confirmed a significantly suppressed EBV-specific cytotoxic T-cell (CTL) response to the LCL. EBV reactivation might have been brought about by suppressed CTL activity which could have been due to low dose PSL administration or aging. Since the EBV-DNA titer decreased as AIHA improved, we concluded that EBV might have played a role in the development of anemia.
Highly Sb-Rich Ge-Sb-Te Engineering in 4Kb Phase-Change Memory for High Speed and High Material Stability Under Cycling (2019)

In this paper we present the engineering of highly Sb-rich Ge-Sb-Te phase-change materials integrated in state-of-the-art Phase-Change Memory devices in 4Kb arrays. Thanks to an innovative composition called “delta” or δ-GST, high speed performance and high material stability under cycling is achieved in arrays and demonstrated by both physicochemical analysis and electrical characterization. Finally, the origin of the outstanding high speed in our innovative compound is revealed.
A novel N-chlorotaurine–corticosteroid combination as a preservative-free local disinfectant: Influence on the ciliary beat frequency in vitro (2006)

The combination of 1% NCT + 0.5 mg/ml FP decreased the CBF to 42.17% of its original value after 20 min. Treatment with BAC lowered the CBF depending on the concentration to 96.61% of its original value with 0.04 mg/ml, to 91.90% with 0.1 mg/ml, to 63.46% with 0.2 mg/ml and to 0% with 0.5 mg/ml. After rinsing in saline, the CBF of samples treated with 1% NCT + 0.5 mg/ml FP recovered to 68.93% of its original value.
Phase 1, open-label, dose-escalation and expansion study of ABBV-399, an antibody drug conjugate (ADC) targeting c-Met, in patients (pts) with advanced solid tumors. (2016)

2510 Background: The c-Met receptor is overexpressed in multiple tumors. ABBV-399 is a first-in-class antibody-drug conjugate (ADC) comprised of the anti-c-Met antibody, ABT-700, and monomethyl auristatin E. Although prior efforts at targeting c-Met overexpression have met with limited clinical success, an ADC directed against c-Met represents a unique strategy to deliver a potent cytotoxin directly to c-Met+ tumor cells. Methods: In a 3+3 dose escalation design, ABBV-399 was administered at doses ranging from 0.15 to 3.3 mg/kg once every 21 days to pts with metastatic solid tumors (NCT02099058). The recommended single-agent phase 2 dose (RPTD) of ABBV-399 was then studied in a dose-expansion cohort in pts with c-Met+ (immunohistochemistry (IHC) ≥2+) non-small cell lung cancer (NSCLC). c-Met overexpression was assessed by an IHC assay utilizing the SP44 antibody (Ventana). Results: As of January 4, 2016, 45 pts received at least 1 dose of ABBV-399. Dose-proportional increases of area under the curve (AUC) for ABBV-399 and total antibody were observed after single dose administration. Half-lives for ABBV-399 and total antibody were approximately 2-4 days. Dose-limiting toxicity (DLT) of febrile neutropenia occurred in 1 pt at 3 mg/kg and 1 pt (with septic shock) at 3.3 mg/kg. The RPTD of 2.7 mg/kg was chosen based primarily on safety and tolerability. There were no toxic deaths. Treatment-related adverse events occurring in ≥10% of pts (including all dose levels and all grades) were fatigue (20%), nausea (17.8%), neuropathy (13.3%), decreased appetite (13.3%), hypoalbuminemia (11.1%), and vomiting (11%). 3/10 evaluable c-Met+ NSCLC pts had a partial response; the duration of response ranged from 1+ to 5 months. There were no responses among 9 pts with c-Met negative tumors. Conclusions: ABBV-399 is well tolerated at the RPTD of 2.7 mg/kg and has demonstrated promising anti-tumor activity in pts with cMet+ NSCLC. The study will continue to assess the anti-tumor activity and safety of ABBV-399 in c-Met+ pts both as monotherapy and in combination with standard of care. Clinical trial information: NCT02099058.
Application of phase-transfer catalysis to the chemical modification of cross-linked polystyrene resins (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplication of phase-transfer catalysis to the chemical modification of cross-linked polystyrene resinsJean M. J. Frechet, Marc D. De Smet, and M. Jean FarrallCite this: J. Org. Chem. 1979, 44, 11, 1774–1779Publication Date (Print):May 1, 1979Publication History Published online1 May 2002Published inissue 1 May 1979https://pubs.acs.org/doi/10.1021/jo01325a006https://doi.org/10.1021/jo01325a006research-articleACS PublicationsRequest reuse permissionsArticle Views430Altmetric-Citations108LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pancreas tumor interstitial pressure catheter measurement (2016)

This paper highlights the methodology in measuring interstitial pressure in pancreatic adenocarcinoma tumors. A Millar Mikrotip pressure catheter (SPR-671) was used in this study and a system was built to amplify and filter the output signal for data collection. The Millar pressure catheter was calibrated prior to each experiment in a water column at 37&deg;C, range of 0 to 60 inH2O (112 mmHg), resulting in a calibration factor of 33 mV / 1 inH2O. The interstitial pressures measured in two orthotopically grown pancreatic adenocarcinoma tumor were 57 mmHg and 48 mmHg, respectively. Verteporfin uptake into the pancreatic adenocarcinoma tumor was measured using a probe-based experimental dosimeter.
Adaptively Determination of Model Order of SVD-based Harmonics and Interharmonics Estimation (2023)

The singular value decomposition (SVD) is one of the most popular methods in harmonics and interharmonics estimation. However, its accuracy strongly depends on the correctness of the selected model order. To this purpose, this work aims at contributing to the correct estimation of the model order. This is achieved by exploiting the energy of the singular values (SVs). Firstly, the relationship between one frequency component and its corresponding SVs is theoretically investigated. Secondly, a new indicator is proposed for determining the model order, which denotes the energy of the k-th pair of consecutive SVs. Thirdly, an adaptive threshold is defined for separating signal components from noise. This way, the number of components can be obtained for unknown noise levels. Finally, the effectiveness and robustness of the proposed method has been validated by simulations. They have been run implementing typical signals designed according to the harmonics and interharmonics measurements standard, the IEC standard 61000-4-7.
Automatic Emission Spots Identification in Static and Dynamic Imaging by Research of Local Maxima (2014)

Abstract For VLSI, internal electrical measurements are key steps to solve design debug issues and to perform failure analysis. Due to multiple metal layers, active areas of the chip are only accessible from the backside of the die. The ability of optical contactless techniques to operate through the silicon substrate and the few sample preparation required have widely contributed to promote them as unavoidable tools of the defect localization workflow. Timing issue or unusual consumption can be detected by static and dynamic photon emission analysis. The identification of the emission spots is an essential step of the process. Due to scaling, more and more emission nodes are located within the acquisition area so that large variations of emission intensity can exist. Because of various limitations, former thresholding techniques cannot ensure an exhaustive localization. In this paper, an automated process is reported to locate spots in these complex areas. We will underline the challenge and define application boundaries of this technique.
Brain Correlates of Stuttering and Syllable Production (2004)

This article reports a gender replication study of the P. T. Fox et al. (2000) performance correlation analysis of neural systems that distinguish between normal and stuttered speech in adult males. Positron-emission tomographic (PET) images of cerebral blood flow (CBF) were correlated with speech behavior scores obtained during PET imaging for 10 dextral female stuttering speakers and 10 dextral, age- and sex-matched normally fluent controls. Gender comparisons were made between the total number of voxels per region significantly correlated with speech performance (as in P. T. Fox et al., 2000) plus total voxels per region that were significantly correlated with stutter rate and not with syllable rate. Stutter-rate regional correlates were generally right-sided in males, but bilateral in the females. For both sexes the positive regional correlates for stuttering were in right (R) anterior insula and the negative correlates were in R Brodmann area 21/22 and an area within left (L) inferior frontal gyrus. The female stuttering speakers displayed additional positive correlates in L anterior insula and in basal ganglia (L globus pallidus, R caudate), plus extensive right hemisphere negative correlates in the prefrontal area and the limbic and parietal lobes. The male stuttering speakers were distinguished by positive correlates in L medial occipital lobe and R medial cerebellum. Regions that positively correlated with syllable rate (essentially stutter-free speech) in stuttering speakers and controls were very similar for both sexes. The findings strengthen claims that chronic developmental stuttering is functionally related to abnormal speech-motor and auditory region interactions. The gender differences may be related to differences between the genders with respect to susceptibility (males predominate) and recovery from chronic stuttering (females show higher recovery rates during childhood).
Sunlight-induced crosslinking of 1,2-polybutadienes: access to fluorescent polymer networks (2013)

The efficient sunlight-induced crosslinking of 1,2-polybutadienes to generate fluorescent patterns with spatial resolution is reported. The photochemical conjugation method employed is based on a nitrile imine-mediated tetrazole–ene cycloaddition (NITEC) reaction, which proceeds under UV-light irradiation (λmax = 312 nm) at ambient temperature in the absence of any catalyst. The NITEC reaction between 1-pentene and a newly designed di-linker, consisting of two photosensitive diaryl-substituted tetrazoles joined by a tetraethylene glycol spacer, was investigated in an initial study. Detailed characterization of a small molecule model study was performed by size exclusion chromatography (SEC), UV-vis and fluorescence spectroscopy as well as electrospray-ionization mass spectrometry (ESI-MS), which was also employed for monitoring the progress of the reaction (100% conversion in 20 min). Finally, two 1,2-polybutadienes of disparate molar masses were each photocrosslinked with the di-linker. The crosslinking reaction parameters, such as concentration, di-linker fraction and reaction time were optimized via SEC analysis and gravimetric determination of gel fractions. The applicability of the novel crosslinking technology for generating spatially controlled highly fluorescent gel patterns is demonstrated in a solvent-free reaction for 2 h under sunlight. In summary, the current study introduces an efficient light-triggered technology platform for crosslinking polymers carrying non-activated double bonds.
Thermally Evaporated In2O3 Nanoloquats with Tunable Broad-Band Emissions (2008)

We describe synthesis of In2O3 nanoloquats grown by thermal evaporation under different oxygen flow rates and temperatures. Gold nanoparticles were used the catalysts and were dispersed on the silicon wafer to assist growth of In2O3 nanoloquats. The nanostructures of In2O3 nanoloquats were characterized by scanning electron microscopy, transmission electron microscopy and X-ray diffraction. The photoluminescence study reveals that In2O3 nanoloquats could emit different broadband luminescence peaks in the range of 410-620 nm by tuning different oxygen flow rates and temperatures. The wide tuning range in the emission peaks of In2O3 nanoloquats has potential in applications of white light illumination.
Smoking Modulates Different Secretory Subpopulations Expressing SARS-CoV-2 Entry Genes in the Nasal and Bronchial Airways (2021)

<b>Background</b> : SARS-CoV-2 infection and disease severity are influenced by viral entry (VE) gene expression patterns in airway epithelium. The similarities and differences of VE gene expression (ACE2, TMPRSS2, and CTSL) across nasal and bronchial compartments has not been fully characterized using matched samples from large cohorts. <b>Results</b> : Gene expression data from 793 nasal and 1,673 bronchial brushes obtained from individuals participating in lung cancer screening or diagnostic workup revealed that smoking was the only clinical factor significantly and reproducibly associated with VE gene expression. ACE2 and TMPRSS2 expression were higher in smokers in the bronchus but not in the nose. scRNA-seq of nasal brushings indicated that ACE2 co-expressed genes were highly expressed in club and C15orf48 <sup>+</sup> secretory cells while TMPRSS2 co-expressed genes were highly expressed in keratinizing epithelial cells. In contrast, these ACE2 and TMPRSS2 modules were highly expressed in goblet cells in scRNA-seq from bronchial brushings. Cell-type deconvolution of the RNA-seq confirmed that smoking increased the abundance of several secretory cell populations in the bronchus, but only goblet cells in the nose. <b>Conclusions</b> : The association of ACE2 and TMPRSS2 with smoking in the bronchus is due to their high expression in goblet cells which increase in abundance in current smoker airways. In contrast, in the nose these genes are not predominantly expressed in cell populations modulated by smoking. Smoking-induced VE gene expression changes in the nose likely has minimal impact on SARS-CoV-2 infection, but in the bronchus, smoking may lead to higher viral loads and more severe disease.
Fast Decentralized Nonconvex Finite-Sum Optimization with Recursive Variance Reduction (2022)

Related DatabasesWeb of Science You must be logged in with an active subscription to view this.Article DataHistorySubmitted: 20 August 2020Accepted: 01 September 2021Published online: 05 January 2022Keywordsdecentralized optimization, stochastic optimization, nonconvex optimization, variance reduction, gradient trackingAMS Subject Headings90C26, 90C15, 93A16Publication DataISSN (print): 1052-6234ISSN (online): 1095-7189Publisher: Society for Industrial and Applied MathematicsCODEN: sjope8