gebhart/patrepeval huggingface dataset:
Ultrafast Generation of Ferromagnetic Order via a Laser-Induced Phase Transformation in FeRh Thin Films (2004)

It is demonstrated that ultrafast generation of ferromagnetic order can be achieved by driving a material from an antiferromagnetic to a ferromagnetic state using femtosecond optical pulses. Experimental proof is provided for chemically ordered FeRh thin films. A subpicosecond onset of induced ferromagnetism is followed by a slower increase over a period of about 30 ps when FeRh is excited above a threshold fluence. Both experiment and theory provide evidence that the underlying phase transformation is accompanied, but not driven, by a lattice expansion. The mechanism for the observed ultrafast magnetic transformation is identified to be the strong ferromagnetic exchange mediated via Rh moments induced by Fe spin fluctuations.
Isolation and sequencing of a cDNA clone homologous to the v-sis oncogene from human endothelial cells. (1986)

A clone containing the 3' end of the mRNA for the human c-sis gene (homologous to the B chain of platelet-derived growth factor) was isolated from a cDNA library derived from human umbilical vein endothelial cells and then sequenced. The analysis of possible translation products in all three reading frames indicated that the A chain of platelet-derived growth factor was not coded for within the 3' end of the c-sis mRNA. The 3' end of the mRNA for c-sis is contained in or adjacent to exon 6.
A Board Level Study of an Array of Ball Grid Components—Aerodynamic and Thermal Measurements (2003)

Electronic package manufacturers publish thermal characteristics of components, which are measured using standard tests, measuring a thermal resistance value for a single component on a standard test printed circuit board (PCB). This limits the applicability of the characterization, as it does not show what aerodynamic or thermal interaction each package will have in a real system. This paper presents a new board-level electronics system test vehicle consisting of an array of ball grid components on three different effective thermal conductivity multi-layer PCB’s. Aerodynamic and thermal measurements are presented. It appears that PCB’s populated with low profile electronic packages behave like flat plates, leading to the proposition that component temperatures can be calculated using flat plate predictions. It is shown how both the airflow and the board conductivity can have a critical effect on the junction temperature, and a simple design rule is suggested, in terms of influence factors, to take account of these effects. These will lead to better estimates of electronic system reliability in the early part of the design cycle.
Improved capping layers for suppression of ambient ageing in porous silicon (1998)

Accelerator-based nuclear techniques were used to study the ageing of as-prepared and aluminium-capped porous silicon samples with a porosity of 55% and with two different morphologies (microporous and mesoporous). Aluminium surface capping layers with thicknesses in the range 0.1-0.5 m were applied by rf sputtering. The uncapped microporous samples aged more rapidly in air than did mesoporous samples. The sputtered capping layers were found to be effective for stabilizing porous silicon against atmospheric oxidation, irrespective of the thickness of the capping layer.
Native lattice strain induced structural earthquake in sodium layered oxide cathodes (2022)

High-voltage operation is essential for the energy and power densities of battery cathode materials, but its stabilization remains a universal challenge. To date, the degradation origin has been mostly attributed to cycling-initiated structural deformation while the effect of native crystallographic defects induced during the sophisticated synthesis process has been significantly overlooked. Here, using in situ synchrotron X-ray probes and advanced transmission electron microscopy to probe the solid-state synthesis and charge/discharge process of sodium layered oxide cathodes, we reveal that quenching-induced native lattice strain plays an overwhelming role in the catastrophic capacity degradation of sodium layered cathodes, which runs counter to conventional perception-phase transition and cathode interfacial reactions. We observe that the spontaneous relaxation of native lattice strain is responsible for the structural earthquake (e.g., dislocation, stacking faults and fragmentation) of sodium layered cathodes during cycling, which is unexpectedly not regulated by the voltage window but is strongly coupled with charge/discharge temperature and rate. Our findings resolve the controversial understanding on the degradation origin of cathode materials and highlight the importance of eliminating intrinsic crystallographic defects to guarantee superior cycling stability at high voltages.
Analyzing and Visualizing Jump Performance Using Wireless Body Sensors (2012)

Advancement in technology has led to the deployment of body sensor networks (BSN) to monitor and sense human activity in pervasive environments. Using multiple wireless on-body systems, such as physiological data monitoring and motion capture systems, body sensor network data consists of heterogeneous physiologic and motoric streams that form a multidimensional framework. In this article, we analyze such high-dimensional body sensor network data by proposing an efficient, multidimensional factor analysis technique for quantifying human performance and, at the same time, providing visualization for performances of participants in a low-dimensional space for easier interpretation.
Simple and Cost-Efficient Classification of Ballpoint Pen Inks Using Digital Color Analysis (2021)

We report here a simple and cost-effective technique for classification of the samples of writing inks based on their digital color analysis (DCA). The dynamics of artificial aging of writing inks under UV irradiation was studied by means of DCA for the first time. The color of ballpoint pen marks was recorded over time using an ordinary consumer DSLR camera. The inks were classified according to the parameters of their color degradation curves with precision superior to conventional Raman scattering method, which serves as a proof-of-concept of the proposed approach. The reported approach has broad prospects for implementation by criminalists for document investigation when document forgery is suspected. The proposed technique can be of interest not only in the field of forensic science but also for those who deal with dyes and dye-containing materials and their degradation over time as well as for the study of any processes, the evolution of which is reflected in a color change.
1,4-Diaryl-1-cyclopropylbutanes (1992)

1,4-Diaryl-1-cyclopropylbutanes are potent broad spectrum foliar insecticides and, in some cases, acaricides. These highly lipophilic non-ester pyrethroids are relatively safe to fish as well as mammals. The cyclopropyl group is found to be essential; replacement by an isopropyl group results in a dramatic loss in activity. The insecticidal activity, fish safety and mammalian safety are equivalent to relevant standards.
Maintenance of Pluripotent Stem Cells is Influenced by Ser/Thr Metabolism (2014)

Abstract Recent studies have suggested not only that stem cells have different metabolic requirements than terminally differentiated cells, but also that metabolic intermediates may play a role in the maintenance of stem cells. It has long been clear that changes in acetylation and methylation of histones, as well as methylation of DNA play critical roles in deciding cell fate. The availability of critical intermediates in metabolism, especially S-adenosylmethionine (SAM), acetyl-CoA, nicotinamide adenine dinucleotide (NAD) and a-ketoglutarate play critical roles in modulating acetylation and methylation of histones and methylation of DNA. In the course of evaluating an unusual requirement of threonine (Thr) for the growth of murine embryonic stem cells, we found that metabolism of Thr to glycine (Gly) and the subsequent use of the methyl group of Gly for converting homocysteine to methionine is critical for maintaining high levels of SAM and low levels of S-adenosyl-homocysteine. Importantly, depletion of Thr from the media resulted in decreased tri-methylation of histone H3 lysine-4 (H3K4me3), leading to slowed growth and increased differentiation. Thus, abundance of SAM appears to influence H3K4me3, providing a possible mechanism by which modulation of a metabolic pathway might influence stem cell fate. Demethylation of histones and DNA can also be controlled by metabolic intermediates. Mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2 that drive acute myeloid leukemia (AML) and other cancers, produce an oncometabolite (2-hydrogyglutarate) that can compete with the a-ketoglutarate requirement for enzymes involved in hydroxy-methylation and subsequent demethylation of DNA and histones. Recent studies indicate that 2-hydroxyglutarate plays a role in blocking differentiation of cancer cells. These and other observations linking intermediates in metabolism to stem cell maintenance will be discussed. Disclosures Cantley: Agios Pharmaceuticals: Consultancy, Equity Ownership, Membership on an entity's Board of Directors or advisory committees, Patents &amp; Royalties.
Innovative coupled hydrometallurgical and pyrochemical processes for rare earth recycling (2018)

Rare earth elements (REE)Rare earth elements (ree) are regarded today as highly critical raw materialsCritical raw materials but currently lack suitable recyclingRecycling processes. A combined hydro- and pyrometallurgical process aimed at REE recoveryRecovery from used NdFeB permanent magnetsMagnets was recently developed by the CEA. The process integrates the physico-chemical treatment of magnetsMagnets , followed by a solvent extractionSolvent extraction step for the recoveryRecovery and intra-REE separationRee separation using a selective extractant. A subsequent pyrometallurgical treatment via molten chlorideChloride salt electrolysis allowed the isolation of pure Dy metal. Technical-economic assessment and life-cycle analysis were also conducted. Following this first successful demonstration, a new project aimed at the recoveryRecovery of REE from end-of-life nickelNickel -metal-hydride batteriesBatteries is currently being developed in association with industrial and academic partners. The project aims at evaluating from an experimentalExperimental and economic perspective different processes converging at the production of value-added products such as cermet materials for catalytic applications, purified REO concentrates, or metallic alloys.
Performance modeling for early analysis of multi-core systems (2007)

Performance analysis of microprocessors is a critical step in defining the microarchitecture, prior to register-transfer-level (RTL) design. In complex chip multiprocessor systems, including multiple cores, caches and busses, this problem is compounded by complex performance interactions between cores, caches and interconnections, as well as by tight interdependencies between performance, power and physical characteristics of the design (i.e., floorplan). Although there are many point tools for the analysis of performance, or power, or floorplan of complex systems-on-chip (SoCs), there are surprisingly few works on an integrated tool that is capable of analyzing these various system characteristics simultaneously and allow the user to explore different design configurations and their effect on performance, power, size and thermal aspects. This paper describes an integrated tool for early analysis of performance, power, physical and thermal characteristics of multi-core systems. It includes cycle-accurate, transaction-level SystemC-based performance models of POWER processors and system components (i.e., caches, buses). Power models, for power computation, physical models for floorplanning and packaging models for thermal analysis are also included. The tool allows the user to build different systems by selecting components from a library and connecting them together in a visual environment. Using these models, users can simulate and dynamically analyze the performance, power and thermal aspects of multi-core systems.
Two Cycles of ABVD Followed by Involved Field Radiotherapy with 20 Gray (Gy) Is the New Standard of Care in the Treatment of Patients with Early-Stage Hodgkin Lymphoma: Final Analysis of the Randomized German Hodgkin Study Group (GHSG) HD10. Study Supported by the Deutsche Krebshilfe and in Part by the Competence Network Malignant Lymphoma. (2009)

Abstract Abstract 716 Background: There has been an ongoing debate on the best treatment for patients with early favourable Hodgkin lymphoma (HL). Open questions include the choice between combined modality treatment or chemotherapy only, the number of chemotherapy cycles needed and the optimal radiation dose. The GHSG thus conducted a randomized study for patients with early-stage favourable Hodgkin lymphoma (HD10) in which these questions were addressed. Methods: HD10 was an international prospectively randomized multicenter trial comparing 2 and 4 cycles of ABVD as well as 20Gy or 30Gy involved field radiotherapy (IFRT) in a 2 × 2 statistical design. Between 5/1998 and 1/2003, a total of 1370 patients from 329 centers were randomized into four arms: 4 × ABVD + 30Gy; 4 × ABVD + 20Gy; 2 × ABVD + 30Gy; 2 × ABVD + 20Gy. All patients had their initial histology reviewed by a lymphoma expert panel. Documentation was complete in more than 99,1% of cases for this final analysis. Results: Patients were equally balanced for age, gender, stage, histology, performance status and risk factors between arms. There were significant differences in major toxicity (WHO grade III/IV) between 4 × ABVD and 2 × ABVD in the overall number of events (52% vs 33%) including leukopenia (24% vs 15%) and hair loss (28% vs 15%). In terms of radiation dose, there also was a difference in toxicity between 30Gy and 20Gy IFRT (all events: 8.7% vs 2.9%), dysphagia (3% vs 2%), mucositis (3.4% vs 0.7%). Complete remission was achieved in 97% of patients treated with 4 × ABVD, 97% with 2 × ABVD, 99% after 30Gy and 97% after 20Gy. With a median follow-up of 79–91 months, there was no significant difference between 4 × ABVD and 2 × ABVD in terms of overall survival at 5 years (OS: 4 × ABVD 97.1%; 2 × ABVD: 96.6%), freedom from treatment failure (FFTF: 93.0% vs 91.1%) and progression free survival (PFS: 93.5% vs 91.2%). For the radiotherapy question, there were also no significant differences between patients receiving 30Gy IFRT and those with 20Gy IFRT in terms of OS (97.6% vs 97.5%), FFTF (93.4% vs 92.9%) and PFS (93.7% vs 93.2%), respectively. Importantly, there was also no significant difference in terms of OS, FFTF and PFS when all four arms were compared. Conclusion: Two cycles of ABVD followed by 20Gy IFRT is the new GHSG standard of care for Hodgkin patients in early favourable stages. Disclosures: No relevant conflicts of interest to declare.
Through Recess and Regrowth Gate Technology for Realizing Process Stability of GaN-Based Gate Injection Transistors (2017)

A new gate recess process technology has been successfully implemented in normally off GaN-based gate injection transistors, in order to improve the process stability. In this process, unlike the conventional gate recess process, the initial AlGaN barrier layer in the gate region is fully removed, and then, AlGaN is reproduced by epitaxial regrowth for the first time. By using this technology, the standard deviation of threshold voltage ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${V} _{\mathsf {th}}$ </tex-math></inline-formula> ) improves drastically from 229 to 63 mV in 6-in substrate. Furthermore, <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${V} _{\mathsf {th}}$ </tex-math></inline-formula> values were easily controlled from 1.0 to 2.3 V by changing the regrown AlGaN thickness, without changing other dc characteristics and their distributions.
Enhancement of <i>In Vitro</i> Skin Transport and <i>In Vivo</i> Hypoglycemic Efficacy of Glimepiride Transdermal Patches (2014)

Purpose: To utilize hydroxybutyl-β-cyclodextrin (HB-β-CD) and polyvinyl pyrrolidone (PVP) for the enhancement of the transdermal delivery of glimepiride (GMD).Methods: Matrix-type transdermal patches containing GMD, drug coprecipitate or its inclusion complex were prepared using different gelling agents, viz, hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), carbopol and chitosan. In vitro skin permeation evaluation of the formulations was conducted using automated diffusion system. Selected patch formulations were assessed for hypoglycemic activity as well as for GMD plasma concentration in rats.Results: GMD- hydroxybutyl-β-cyclodextrin (HB-β-CD) binary systems (1:2 molar ratio) enhanced GMD aqueous solubility by &gt; 10-fold. Diffusion test showed improved release of GMD-HB-β-CD inclusion complex compared with GMD alone. Maximum cumulative amounts of GMD- HB-β-CD that permeated through rat skin was 26.97 and 14.28 µg/cm2 for patches prepared with fchitosan and HPMC, respectively. Thus, GMD-chitosan patches showed significantly higher (p &lt; 0.05) drug permeation than GMD-HPMC after 6 h. Both chitosan and HPMC patches of GMD-HB-β-CD demonstrated substantial reduction (p &lt; 0.05) in blood glucose level (192.67 ± 21.18 and 201 ± 15.11 mg/ dl, respectively), compared with the baseline value of 240 mg/ dl.Conclusion: Application of chitosan and HPMC transdermal patches of GMD-HB-β-CD can serve as a potential alternative to peroral GMD with improved bioavailability and patient compliance.Keywords: Glimepiride, Transdermal patch, Coprecipitate, Inclusion complex, Hydroxypropyl methylcellulose, Polyvinyl pyrrolidone, Chitosan, Skin permeation
Latte: a language, compiler, and runtime for elegant and efficient deep neural networks (2016)

Deep neural networks (DNNs) have undergone a surge in popularity with consistent advances in the state of the art for tasks including image recognition, natural language processing, and speech recognition. The computationally expensive nature of these networks has led to the proliferation of implementations that sacrifice abstraction for high performance. In this paper, we present Latte, a domain-specific language for DNNs that provides a natural abstraction for specifying new layers without sacrificing performance. Users of Latte express DNNs as ensembles of neurons with connections between them. The Latte compiler synthesizes a program based on the user specification, applies a suite of domain-specific and general optimizations, and emits efficient machine code for heterogeneous architectures. Latte also includes a communication runtime for distributed memory data-parallelism. Using networks described using Latte, we demonstrate 3-6x speedup over Caffe (C++/MKL) on the three state-of-the-art ImageNet models executing on an Intel Xeon E5-2699 v3 x86 CPU.
Targeting class switch recombination plays a potential role in retarding systemic lupus erythematosus (SLE) (2017)

Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease mediated mainly by autoantibodies reactive to nuclear acids and proteins. These autoantibodies are mostly of IgG isotype, indicating that class-switch recombination (CSR) may play an important role in the development of SLE. CSR is initiated by the enzyme, activation-induced cytidine deaminase (AID) which induces double strand DNA breaks then repaired by homologous recombination using the RAD51 complex. We hypothesize that therapeutic targeting of CSR will retard the development of SLE by inducing cell death in AID-expressed B cells and reducing pathogenic IgG antibodies. The BXSB/MpJ mouse is a well characterized model of human SLE, exhibiting a robust germinal center response and copious production of immunoglobulins. 4,4’-diisothiocyanatostilbene-2-2’-disulfonic acid (DIDS) is a molecule which impairs homologous recombination by inhibiting the binding of RAD51 complex to DNA. In this study, male BXSB/MpJ mice were injected with DIDS or control. Treated mice showed a reduction in the germinal center B cell population and a corresponding decrease in follicular T helper cells. T1 B cell and follicular B cell populations were significantly decreased in DIDS treated mice but no changes were found in marginal zone B cells. Sera were analyzed for the immunoglobulin levels and antinuclear antibodies. These findings demonstrate that targeting CSR by DIDS reduces potentially pathogenic B lymphocyte populations and may be a viable novel therapeutic option in the treatment of SLE.
A Binary XML for Scientific Applications (2006)

XML provides flexible, extensible data models and type systems for structured data, and has found wide-acceptance in many domains. XML processing can be slow, however, especially for scientific data, thus leading to the conventional wisdom that XML is not appropriate for such data. Instead, data is stored in specialized binary formats, and is transmitted via work-arounds such as attachments and base64 encoding. Though these work-arounds can be useful, they nonetheless relegate scientific data to second-class status within the Web services framework; and they generally require yet another API, data model, and type system. An alternative solution is to use more efficient encodings of XML, often known as "binary XML". Using XML uniformly throughout an application simplifies and unifies design and development. In this paper we present a binary XML format and implementation for scientific data called Binary XML for Scientific Applications (BXSA). We show that performance is comparable to that of commonly used scientific data formats such as netCDF. These results challenge the prevailing practice of handling control and data separately in scientific applications, with Web services for control and specialized binary formats for data
Prediction of low-energy boron doping profile for ultrashallow junction formation by hybrid molecular dynamics method (2015)

Abstract Our original hybrid method combining tight-binding quantum chemical and classical molecular dynamics was first applied to the low-energy doping process of boron into a silicon substrate, which has a depth of more than 10 nm that is needed to evaluate an ultrashallow junction position. Tight-binding quantum chemical molecular dynamics calculation was used for an injected boron atom and surrounding silicon atoms within a sphere with a radius of 0.5 nm centered at the boron atom. This method is advantageous in treating the many-body collision effect and electron–electron interaction, which are more important in low-energy doping, compared with the Monte Carlo method with binary collision approximation. A comparison with a plasma doping experiment was also carried out. The junction positions were 6.2 nm for boron doping at an initial kinetic energy of 200 eV in the simulation results and 6.4 nm for 200 eV in the experimental results. Good agreement between simulation and experimental results indicates that our hybrid molecular dynamics method is applicable to doping profile prediction in a silicon structure with a depth of more than 10 nm that is needed to evaluate ultrashallow junction formation.