gebhart/patrepeval huggingface dataset:
Frequency controlled terahertz wave parametric generation based on spectral drill cavity (2022)

We demonstrated frequency controlled terahertz wave generation based on parametric wavelength conversion in a nonlinear MgO:LiNbO3 crystal. The pumping beam is generated using a PPLN-OPG seeded by a stabilized laser beam as traceable to the national standard. The generated pulses are amplified by a KTA-OPA pumped by a SLM Nd:YAG MOPA system. The seeding beam is monitored and controlled by a “spectral drill” cavity. The frequency of seeding beam is observed as intensity error signal. We expect that these methods will open up new fields.
Flexible Antenna Integrated With an Epitaxial Lift-Off Solar Cell Array for Flapping-Wing Robots (2014)

We describe the integration of a flexible UHF antenna with an epitaxial lift-off thin-film III-V solar cell array used for power generation and wireless communication in a flapping-wing robotic platform. The antenna is configured to utilize the cells and their interconnections as a part of the radiating element, leading to compact multifunctional antenna/solar cell array surface. The high junction capacitance of individual solar cells allows RF current conduction through the cells without an associated power penalty. Metallic interconnects in the solar cell array carry both the DC power as well as forming part of the UHF antenna. To suppress RF current leakage into the DC circuit used for conducting the solar cell current, a RF choke is inserted between the antenna and the solar cells in the DC path. The performance characteristics of the integrated antenna and solar cell array verify the predicted performance of the antenna for reliable communication. Further, mounting the thin film solar cell array on a 25 μm thick Kapton sheet is shown to be a robust power source when positioned on the flexible wings of flapping robotic platforms. Details about design procedure and performance of the proposed integrated antenna are discussed.
A Model for Simulating Polarization Switching and AF-F Phase Changes in Ferroelectric Ceramics (1998)

A computational micromechanics model for polycrystalline ferroelectric ceramics developed by Chen and Lynch (1997) is modified and applied to the simulation of ferroelectric and ferroelastic switching of the tetragonal and the rhombohedral crystal structures, and to antiferroelectric to ferroelectric phase changes. Interactions between different grains in the ceramic are considered. Two switching criteria are used, one for ferroelectric switching and one or phase changes. Experimental results for both types of materials are simulated.
Low temperature free-radical reactions initiated with tert-butyl p-benzoylperbenzoate. Selective acyl radical additions to substituted olefins (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLow temperature free-radical reactions initiated with tert-butyl p-benzoylperbenzoate. Selective acyl radical additions to substituted olefinsPeter Gottschalk and D. C. NeckersCite this: J. Org. Chem. 1985, 50, 19, 3498–3502Publication Date (Print):September 1, 1985Publication History Published online1 May 2002Published inissue 1 September 1985https://pubs.acs.org/doi/10.1021/jo00219a015https://doi.org/10.1021/jo00219a015research-articleACS PublicationsRequest reuse permissionsArticle Views518Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Endothelin Antagonists. Part 2. Evaluation of 2,1,3‐Benzothiadiazole as a Methylendioxyphenyl Bioisoster. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Colorimetric Minisequencing Assay for the Mutation in Codon 506 of the Coagulation Factor V Gene (1997)

Summary We describe a colorimetric screening method for the mutation in codon 506 of the coagulation factor V gene. The nucleotide at the site of the FV:Q506 mutation is identified in an immobilized amplified DNA template by extension of a primer with a hapten-labelled dNTP using a DNA polymerase. The incorporated hapten is detected by an antibody- alkaline phosphatase conjugate that catalyses the formation of a coloured end product. The assay is carried out in a microtiter plate format, and the procedure is identical to that of enzyme immunoassays. It unequivocally identifies the FV:Q506 mutation in heterozygous and homozygous form. The colorimetric minisequencing method gave the same result as a 3H-based minisequencing assay and restriction site analysis with Mnll used as reference methods. Because of its simple format and numeric result, the novel colorimetric minisequencing method should be an attractive alternative for screening for the FV:Q506 mutation in clinical laboratories.
Influence of a Black Sphere and of a Black Cylinder upon the Neutron Density in an Infinite Non-Capturing Medium (1951)

For a black body inserted into a homogeneous scattering medium, the neutron density at large distances from the body is determined using the perturbation method for the case when the scattering in the scattering medium is assumed elastic and isotropic capture is absent and the following four types of the black body are considered: (i) a sphere of radius small compared with the mean free path in the scattering medium; (ii) a sphere of radius large compared with the mean free path; (iii) an infinitely long cylinder of radius small compared with the mean free path; (iv) an infinitely long cylinder of radius large compared with the mean free path. Combining the results for the above limiting cases with the results obtained by other methods the distribution is also estimated for a sphere and an infinitely long cylinder of intermediate radii.
Lateral depletion-mode thyristors in SOI substrates (2002)

The LDMT (lateral depletion-mode thyristor), a new type of lateral MOS-controlled thyristor, is presented. This device is fabricated in a SOI (silicon-on-insulator) substrate, and uses the substrate as back-gate to turn off the thyristor action. The LDMT achieves turn-off via MMCI (MOS-controlled current interruption), whereby the displacement current of an MOS capacitor is used to interrupt the thyristor's current flow. This device is shown to have a maximum controllable current, in current implementations, which is 8.3 times its holding current. Its switching speed has been measured at less than 600 ns. The authors describe the LDMT and the MCCI mechanism, present experimental results, and discuss the advantages and disadvantages of this device.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Thermal annealing effects on a representative high-k/metal film stack (2006)

A high-k/metal film stack in a conventional complementary metal oxide semiconductor (CMOS) flow is a key candidate in the semiconductor industry for replacing the existing poly-silicon gate and silicon dioxide (SiO2) gate dielectric to reduce poly depletion and gate leakage. During conventional CMOS integration, the high-k/metal film stack is exposed to a high thermal budget process. In this work, an atomic layer deposition (ALD)-based hafnium oxide (HfO2)/titanium nitride (TiN) film stack (representative of the high-k/metal film stack) was annealed at 1000 °C to determine any change in the physical and electrical properties, such as thickness, surface roughness, density, sheet resistance, refractive index, extinction coefficient, composition, C–V characteristics, work function and etch rate. Although there was no significant electrical impact, some significant physical changes have been observed, which impact the process of integrating high-k/metal film stacks, especially in dual metal gate CMOSs.
Imaging morphogenesis of Candida albicans during infection in a live animal (2010)

Candida albicans is an opportunistic human fungal pathogen that requires an intact host immune response to prevent disease. Thus, studying host-pathogen interactions is critical to understanding and preventing this disease. We report a new model infection system in which ongoing C. albicans infections can be imaged at high spatial resolution in the ears of living mice. Intradermal inoculation into mouse ears with a C. albicans strain expressing green fluorescent protein results in systemic C. albicans infection that can be imaged in vivo using confocal microscopy. We observed filamentous growth of the organism in vivo as well as formation of microabscesses. This model system will allow us to gain significant new information about C. albicans pathogenesis through studies of host-C. albicans interactions in the native environment.
An SOI-Based Lock-in Pixel with a Shallow Buried Channel for Reducing Parasitic Light Sensitivity and Improving Modulation Contrast (2023)

This paper presents a high-NIR sensitivity SOI-gate lock-in pixel with improved modulation contrast. The proposed pixel has a shallow buried channel and intermediate gates to create both a high lateral electric field and a potential barrier to parasitic light sensitivity. Device simulation results showed that parasitic light sensitivity reduced from 13.7% to 0.13% compared to the previous structure.
Argot2: a large scale function prediction tool relying on semantic similarity of weighted Gene Ontology terms (2012)

The revised algorithm has been already employed and successfully tested during in-house genome projects of grape and apple, and has proven to have a high precision and recall in all our benchmark conditions. It has also been successfully compared with Blast2GO, one of the methods most commonly employed for sequence annotation. The server is freely accessible at http://www.medcomp.medicina.unipd.it/Argot2.
A novel system for the reconstruction of a coronary artery lumen profile in real time: a preclinical validation (2009)

Accurate sizing of vessel diameter is important for understanding the physiology of blood vessels as well as the treatment of coronary and peripheral artery disease. The objective of this study was to validate a novel catheter-based system [the LumenRECON (LR) system] for the real-time reconstruction of lumen cross-sectional area (CSA) along the length of a vessel segment. A total of 22 swine (20 Yorkshire and 2 atherosclerotic Ossabaw swine) were used to evaluate the accuracy, reproducibility, and safety of the system compared with intravascular ultrasound (IVUS). The CSA of the right coronary artery, left anterior descending coronary artery, and left circumflex artery were determined by IVUS and the LR system over a 3- to 4-cm segment in 12 Yorkshire and 2 atherosclerotic Ossabaw swine and 2 postmortem atherosclerotic human hearts. In eight chronic animals, the effect of the LR catheter on the vessel wall was evaluated at 1 day and 2 wk (4 animals each) after the intervention. A Bland-Altman plot of the LR and IVUS data showed a mean difference between the two measurements of 0.055 mm in diameter, which was not statistically significant from zero, indicating a lack of bias in the comparison of the LR system with IVUS. The root mean square error of the two measurements was 10.2% of the mean IVUS diameter. The repeatability of the LR system was assessed using duplicate measurements. The mean of the difference between the two measurements was nearly zero, and the repeatability coefficient was within 4.5% of the mean of the two measurements. No injury or intimal hyperplasia was found acutely or chronically after the use of the LR system. This study establishes the accuracy, reproducibility, and safety of a nonimaging 2.7-Fr catheter for lumen sizing of coronary arteries. The system provides a continuous quantitative axial profile of the mean vessel lumen in real time and may have significant utility in vascular research and clinically in the catheterization laboratory.
[Molecular genetic aspects of neoplasms]. (1999)

The paper presents data on the role of some genes that provide normal positive and negative regulation of cell proliferation. It considers their structural and functional changes that lead to the occurrence and progression of tumors. The characteristics of tumor suppressive genes whose inactivation determines hereditary predisposition to some forms of malignant neoplasms.
Selection and Characterization of Tau Binding ᴅ-Enantiomeric Peptides with Potential for Therapy of Alzheimer Disease (2016)

A variety of neurodegenerative disorders, including Alzheimer disease (AD), are associated with neurofibrillary tangles composed of the tau protein, as well as toxic tau oligomers. Inhibitors of pathological tau aggregation, interrupting tau self-assembly, might be useful for the development of therapeutics. Employing mirror image phage display with a large peptide library (over 109 different peptides), we have identified tau fibril binding peptides consisting of d-enantiomeric amino acids. d-enantiomeric peptides are extremely protease stable and not or less immunogenic than l-peptides, and the suitability of d-peptides for in vivo applications have already been demonstrated. Phage display selections were performed using fibrils of the d-enantiomeric hexapeptide VQIVYK, representing residues 306 to 311 of the tau protein, as a target. VQIVYK has been demonstrated to be important for fibril formation of the full lengths protein and forms fibrils by itself. Here, we report on d-enantiomeric peptides, which bind to VQIVYK, tau isoforms like tau3RD (K19) as well as to full lengths tau fibrils, and modulate the aggregation of the respective tau form. The peptides are able to penetrate cells and might be interesting for therapeutic and diagnostic applications in AD research.
Blunting the rise in body temperature reduces muscle glycogenolysis during exercise in humans (1996)

To examine the effect of blunting the rise in body temperature on exercise metabolism, seven endurance-trained men cycled for 40 min at 65% of maximal oxygen consumption (VO2,max) in an environmental chamber at either 20 degrees C and 20% relative humidity (RH) (T20) or 3 degrees C and approximately 50% RH (T3). The trials were conducted in random order at least 1 week apart. Mean oxygen consumption (VO2) during exercise was not different when comparing the two trials. In contrast, the mean respiratory exchange ratio (RER) was lower (P < 0.05) at T20 compared with T3. Heart rate, rectal temperature and plasma catecholamines were higher (P < 0.05) during exercise at T20 compared with T3, as was post-exercise muscle temperature (P < 0.01). Muscle and blood lactate and blood glucose concentrations were not significantly different when comparing T20 with T3. Net muscle glycogen utilization was greater (P < 0.05) at T20 compared with T3. These results suggest that glycogenolysis in contracting skeletal muscle is reduced during exercise when the rise in body core temperature is attenuated. These changes in carbohydrate metabolism appear to be influenced by alterations in muscle temperature and/or sympatho-adrenal activity.
Accuracy of relative distance measurement with ultra wideband system (2004)

Abstract Due to recent research and relaxed regulations, ultra wideband (UWB) wireless systems have come into practical use. UWB uses a wide bandwidth of several gigahertz and ultra‐short period pulses. Therefore, the position resolution is superior. If pulse locking exists between the transmitter and the receiver, the pulse locking point is shifted if the distance between the transmitter and the received is varied. This shift is corrected by DLL. By measuring this correction, relative position detection is possible. This paper studies the characteristics obtained when using a delay‐lock loop (DLL) for pulse locking, which is important for relative position detection. In particular, it focuses on an environment in which local timing jitter exists. The template waveform on the receiving side and the existence or nonexistence of the loop filter and data modulation are also studied in order to improve the characteristics of the entire system. © 2004 Wiley Periodicals, Inc. Electron Comm Jpn Pt 3, 87(12): 26–36, 2004; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/ ecjc.20075
Supplementary Figure 8 from TLE1 Is an Anoikis Regulator and Is Downregulated by Bit1 in Breast Cancer Cells (2023)

&lt;p&gt;PDF file - 392K, MCF10-CA1a and HOP-92 cells were treated with iRGD-CDD or etoposide (20uM).&lt;/p&gt;
Terahertz line detection by a microlens array coupled photoconductive antenna array (2008)

We present THz ultrashort pulse detection by a photoconductive antenna array consisting of 16 photoconductive antennas. The efficient excitation of the photoconductive antennas has been realized by a microlens array which generates 16 single spots from the exciting fs-laser beam. This combination of optoelectronics and microoptics improves the detection efficiency by an order of magnitude in comparison to an excitation by a line focus.
The MIT LL 2010 speaker recognition evaluation system: Scalable language-independent speaker recognition (2011)

Research in the speaker recognition community has continued to ad dress methods of mitigating variational nuisances. Telephone and auxiliary-microphone recorded speech emphasize the need for a ro bust way of dealing with unwanted variation. The design of recent 2010 NIST-SRE Speaker Recognition Evaluation (SRE) reflects this research emphasis. In this paper, we present the MIT submission applied to the tasks of the 2010 NIST-SRE with two main goals- language-independent scalable modeling and robust nuisance mitigation. For modeling, exclusive use of inner product-based and cepstral systems produced a language-independent computationally scalable system. For robustness, systems that captured spectral and prosodic information, modeled nuisance subspaces using multiple novel methods, and fused scores of multiple systems were implemented. The performance of the system is presented on a subset of the NIST SRE 2010 core tasks.
Synthetic and Structure/Activity Studies on Acid-Substituted 2-Arylphenols: Discovery of 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]- propoxy]phenoxy]benzoic Acid, a High-Affinity Leukotriene B4 Receptor Antagonist (1995)

Structural derivatives of LY255283 have been studied as receptor antagonists of leukotriene B4. Substitution of the 2-hydroxyacetophenone subunit of 1 (LY255283) with a 2-arylphenol group provided entry into several new series that feature various mono- and diacidic core functionality. These new analogues, the subject of a broad structure-activity investigation, displayed significantly increased in vitro and in vivo activity as receptor antagonists of LTB4. A series of diaryl ether carboxylic acids demonstrated especially interesting activity and led to the discovery of compound 43b, 2-[2-propyl-3-[3-[2-ethyl-4-(4- fluorophenyl)-5-hydroxyphenoxy]-propoxy]phenoxy]benzoic acid (LY293111), a 2-arylphenol-substituted diaryl ether carboxylic acid which displayed potent binding to human neutrophils (IC50 = 17 +/- 4.6 nM) and guinea pig lung membranes (IC50 = 6.6 +/- 0.71 nM), inhibition of LTB4-induced expression of the CD11b/CD18 receptor on human neutrophils (IC50 = 3.3 +/- 0.81 nM), and inhibition of LTB4-induced contraction of guinea pig lung parenchyma (pKB = 8.7 +/- 0.16). In vivo, 43b demonstrated potent activity in inhibiting LTB4-induced airway obstruction in the guinea pig when dosed by the oral (ED50 = 0.40 mg/kg) or intravenous (ED50 = 0.014 mg/kg) routes. A specific LTB4 receptor antagonist, 43b had little effect on inhibiting contractions of guinea pig lung parenchyma induced by leukotriene D4 (LTD4), histamine, carbachol, or U46619. Compound 43b has been chosen as a clinical candidate and is currently in phase I studies for a variety of inflammatory diseases.
Thermal Properties of Rocks in the Republic of Korea (2009)

We made 2511 thermal property measurements on igneous, metamorphic, and sedimentary rock samples from Korea. The average thermal conductivities of igneous, metamorphic, and sedimentary rocks are 3.10 W/m-K, 3.76 W/m-K, and 3.54 W/m-K, respectively. Igneous rock can be classified into pluton, hypabyssal rock, and volconic rock; the average thermal conductivities of those rock types are 3.16 W/m-K, 3.26 W/m-K, and 2.77 W/m-K, respectively. Nonclastic sedimentary rock has higher thermal conductivity than clastic sedimentary rock. Thermal conductivity of Palezoic era rock is higher than Mesozoic era rock, because dominant mineral contents play an important role in the determination of thermal conductivity. Thermal conductivity of rocks is influenced by porosity. Therefore thermal conductivity of sedimentary rocks generally decreases with increasing porosity. Thermal conductivity and thermal diffusivity show linear correlation, its correlation coefficient of igneous, metamorphic, and sedimentary rocks are 0.775, 0.855, and 0.876, respectively.
Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT) (2020)

COLCOT ClinicalTrials.gov number, NCT02551094.
‘Its the Economy Stupid’: Predictive Theory of Belief Shift Connecting Economic Stress to Societal Polarization (2023)

Abstract Despite growing concerns about increasing societal polarization, its mechanics remain unclear. A lack of consensus in how to measure and analyze polarization, that takes more than a few hand-picked variables into consideration, have hindered progress. Our new framework (CogNet) computationally distills emergent dependencies between diverse opinions, which then allow us to infer digital twins of society-wide survey responses. In addition to enabling reliable opinion prediction at the individual level to thousands of controversial questions, CogNet allows us to objectively assess societal polarization from social survey data. Analyzing &gt;65K US respondents from the General Social Survey, and &gt; 3.9M European Union participants from the Eurobarometer over half a century, here we provide new evidence that faltering economies forecast greater polarization, and that affective polarizationis a precursor to ideological polarization, yielding insight into how cultural clusters fragment with economic stress, leading to widening gaps between dominant ideologies.