gebhart/patrepeval huggingface dataset:
Data from The B7-H3–Targeting Antibody–Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Patients with relapsed pediatric solid malignancies have few therapeutic options, and many of these patients die of their disease. B7-H3 is an immune checkpoint protein encoded by the &lt;i&gt;CD276&lt;/i&gt; gene that is overexpressed in many pediatric cancers. Here, we investigate the activity of the B7-H3–targeting antibody–drug conjugate (ADC) m276-SL-PBD in pediatric solid malignancy patient-derived (PDX) and cell line–derived xenograft (CDX) models.&lt;/p&gt;Experimental Design:&lt;p&gt;B7-H3 expression was quantified by RNA sequencing and by IHC on pediatric PDX microarrays. We tested the safety and efficacy of m276-SL-PBD in two stages. Randomized trials of m276-SL-PBD of 0.5 mg/kg on days 1, 8, and 15 compared with vehicle were performed in PDX or CDX models of Ewing sarcoma (&lt;i&gt;N&lt;/i&gt; = 3), rhabdomyosarcoma (&lt;i&gt;N&lt;/i&gt; = 4), Wilms tumors (&lt;i&gt;N&lt;/i&gt; = 2), osteosarcoma (&lt;i&gt;N&lt;/i&gt; = 5), and neuroblastoma (&lt;i&gt;N&lt;/i&gt; = 12). We then performed a single mouse trial in 47 PDX or CDX models using a single 0.5 m/kg dose of m276-SL-PBD.&lt;/p&gt;Results:&lt;p&gt;The vast majority of PDX and CDX samples studied showed intense membranous B7-H3 expression (median H-score 177, SD 52). In the randomized trials, m276-SL-PBD showed a 92.3% response rate, with 61.5% of models showing a maintained complete response (MCR). These data were confirmed in the single mouse trial with an overall response rate of 91.5% and MCR rate of 64.4%. Treatment-related mortality rate was 5.5% with late weight loss observed in a subset of models dosed once a week for 3 weeks.&lt;/p&gt;Conclusions:&lt;p&gt;m276-SL-PBD has significant antitumor activity across a broad panel of pediatric solid tumor PDX models.&lt;/p&gt;&lt;/div&gt;
The ODAC Chronicles – Part 2. Statistics and clinical medicine in the USA: the triumph of science over art? (2004)

(2004). The ODAC Chronicles – Part 2. Statistics and clinical medicine in the USA: the triumph of science over art? Expert Review of Anticancer Therapy: Vol. 4, No. 6, pp. 941-944.
Acetal-modified Dextran: An Acid-sensitive, Biodegradable Material for Effective Microparticulate Antigen Delivery (41.53) (2009)

Abstract Polymer-based microparticle systems capable of delivering proteins to antigen-presenting cells (APCs) of the immune system have been investigated for the enhancement of vaccines and immunotherapy. The size of the particles in these systems can be controlled to passively target APCs , without being taken up by other cells in the body. We have developed a new concept in acid-sensitive microparticles based on the use of a water-soluble polysaccharide, dextran, that can be rendered insoluble in aqueous solutions by protecting the hydroxyl groups with acid-sensitive acetals. The resulting polymer is soluble in organic solvents used to generate protein loaded particles by a variety of methods in which the modified polymer is condensed around the encapsulated antigen. Once administered, the acetals rapidly hydrolyze under the acidic conditions present in the phagosomes of APCs to provide a solubility switch that enables particle degradation and release of encapsulated antigen in a controlled manner. We have recently demonstrated the ability to control the rate of particle degradation over a range of minutes to several hours at pH 5, with interesting results observed in how degradation rate affects the presentation of model antigens by APCs to T cells in vitro, as well as how degradation rate may affect the processing mechanism of the released antigen within APCs.
Security andAccuracy Trade-off inAnonymous Fingerprint Recognition (2007)

Thesecurity, lackofanonymity andrevocability ofthebiometric template arecritical issues thatneedtobe addressed inordertovindicate theviability ofbiometric based authentication systems. Several methods havebeenproposed to address these problems. However, mostofthese methods offer loweraccuracies thanthebasesystem wherethetemplate is insecure. Thisisbecause inmostsystems thegaininthesecurity isachieved asaresult oflossinnon-redundant information. Inthispaper, we describe tradeoff between accuracy ofan anonymous system andthesecurity ofthebiometrics system. Asacasestudywestart withahighly secure representation ofafingerprint. Thenwedescribe several methods andshow experimental results proving thateverytimewe addmore information tothesecure representation, theaccuracy increases, however valuable information isrevealed toanadversary. We propose, viaak-trial attack model, howthetrade-off canbe complemented byanother security policy suchasanaccount lockout after agiven numberofattempts. I.INTRODUCTION Biometric systems suchasfingerprint havelimited ac- curacies. Thisisfurther accentuated whenthematching is performed inasecure mannersoasnottoreveal information about theactual biometric. Suchsystems called, anonymous, cancelable orrevocable biometric systems often suffer from loweraccuracies ascompared totheplain counterparts, if anyexist. Inthis paper wedescribe amethod toimprove on theaccuracies ofaregistration freeanonymous fingerprint verification system. We alsodiscuss thesecurity trade-offs madetherein. Theproposed methods havebeentested using areal-time datasetfordifferent cases. InSection IIwepresent abrief discussion oftherecent worksintheareaofanonymous biometrics. Wedescribe ouranonymous fingerprint matching representation inbrief inSection IIIandthemodifications inSection IV.We alsopresent theexperimental analysis inSection IVanddiscuss theprivacy concerns witheach modification inSection V.We drawconclusions andbriefly discuss future research directions inSection VI.
Visual programming in an X Windows workstation environment (1992)

The concept of visual programming, merged with contemporary user interfaces for workstations has tremendous potential to transform non high level programmers into visual programmers. Furthermore, visual programming provides an excellent prototyping environment, one which allows the user to intuitively grasp difficult concepts. In this paper we describe our visual programming environment, termed Eyes , and explain how we intend to apply it toward education.
Monolithic integration of Sb-based photopumped lasers on Si (2005)

The monolithic integration of Sb-based electronic and photonic devices on Si is facilitated by a low defect density (<10/sup 6//cm/sup 2/) AlSb buffer layer. The buffer forms via a unique growth mode that exploits the very large AlSb/Si lattice mismatch and the strong Al-Sb bond.
meso‐ and β‐Pyrrole‐Linked Chlorin‐Bacteriochlorin Dyads for Promoting Far‐Red FRET and Singlet Oxygen Production (2020)

A series of chlorin-bacteriochlorin dyads (derived from naturally occurring chlorophyll-a and bacteriochlorophyll-a), covalently connected either through the meso-aryl or β-pyrrole position (position-3) via an ester linkage have been synthesized and characterized as a new class of far-red emitting fluorescence resonance energy transfer (FRET) imaging, and heavy atom-lacking singlet oxygen-producing agents. From systematic absorption, fluorescence, electrochemical, and computational studies, the role of chlorin as an energy donor and bacteriochlorin as an energy acceptor in these wide-band-capturing dyads was established. Efficiency of FRET evaluated from spectral overlap was found to be 95 and 98 % for the meso-linked and β-pyrrole-linked dyads, respectively. Furthermore, evidence for the occurrence of FRET from singlet-excited chlorin to bacteriochlorin was secured from studies involving femtosecond transient absorption studies in toluene. The measured FRET rate constants, k<sub>FRET</sub> , were in the order of 10<sup>11</sup> s<sup>-1</sup> , suggesting the occurrence of ultrafast energy transfer in these dyads. Nanosecond transient absorption studies confirmed relaxation of the energy transfer product, <sup>1</sup> BChl*, to its triplet state, <sup>3</sup> Bchl*. The <sup>3</sup> Bchl* thus generated was capable of producing singlet oxygen with quantum yields comparable to their monomeric entities. The occurrence of efficient FRET emitting in the far-red region and the ability to produce singlet oxygen make the present series of dyads useful for photonic, imaging and therapy applications.
High-efficiency coupling-insensitive transcutaneous power and data transmission via an inductive link (1990)

This paper presents a new approach for transmitting RF power and signal via an inductive link. Such an approach optimizes the power efficiency of the overall transmission scheme comprising the power amplifier plus the inductive link. Power amplification is based on the single ended class E concept. The power amplification stage is self oscillating, the oscillation frequency thus being influenced by the coupling of the coils. The resulting operating frequency offset yields an improved power transmission performance of the circuit since the oscillation frequency tracks the absolute transmission efficiency maximum. A detailed analysis is given. Realization of the described approach requires a minimal number of circuit components. Experimental and theoretical results are in good agreement.
Crystal structures of CaSiO3 polymorphs control growth and osteogenic differentiation of human mesenchymal stem cells on bioceramic surfaces (2013)

The repair and replacement of damaged or diseased human bone tissue requires a stable interface between the orthopedic implant and living tissue. The ideal material should be both osteoconductive (promote bonding to bone) and osteoinductive (induce osteogenic differentiation of cells and generate new bone). Partially resorbable bioceramic materials with both properties are developed by expensive trial-and-error methods. Structure-reactivity relationships for predicting the osteoinductive properties of ceramics would significantly increase the efficiency of developing materials for bone tissue engineering. Here we propose the novel hypothesis that the crystal structure of a bioceramic controls the release rates, subsequent surface modifications due to precipitation of new phases, and thus, the concentrations of soluble factors, and ultimately, the attachment, viability and osteogenic differentiation of human Mesenchymal Stem Cells (hMSCs). To illustrate our hypothesis, we used two CaSiO<sub>3</sub> polymorphs, pseudo-wollastonite (psw, β-CaSiO<sub>3</sub>) and wollastonite (wol, α-CaSiO<sub>3</sub>) as scaffolds for hMSC culture. Polymorphs are materials which have identical chemical composition and stoichiometry, but different crystal structures. We combined the results of detailed surface characterizations, including environmental Scanning Electron Microscopy (SEM) back-scattered imaging, and spot-analysis and 2D elemental mapping by SEM-Energy Dispersive X-ray (SEM-EDX), High Resolution Transmission Electron Microscopy (HRTEM) and surface roughness analysis; culture medium solution analyses; and molecular/genetic assays from cell culture. Our results confirmed the hypothesis that the psw polymorph, which has a strained silicate ring structure, is more osteoinductive than the wol polymorph, which has a more stable, open silicate chain structure. The observations could be attributed to easier dissolution (resorption) of psw compared to wol, which resulted in concentration profiles that were more osteoinductive for the former. Thus, we showed that crystal structure is a fundamental parameter to be considered in the intelligent design of pro-osteogenic, partially resorbable bioceramics.
Managing obstetric risk: Is your labor and delivery team ready? (2011)

The primary goal of medical professionals is to provide patients with the best possible care and outcome.
Mild Renal Insufficiency Results in Increases in Myocardial Collagen: Evidence for a Heart – Kidney Connection (2008)

Decreased renal function is associated with increased CV morbidity and mortality. The changes mild renal impairment may cause structurally/molecularly in the heart remain unclear. We hypothesized that mild renal dysfunction produced by unilateral nephrectomy(UNX)results in changes in ventricular structure and gene expression in the absence of hypertension or vol overload. Wistar rats were used[sham (S; n=10) and UNX; n=9]. At 4 weeks, GFR was determined by inulin clearance and RBF by PAH. Hearts and kidneys were harvested for histological analysis. Cardiac function assessed by echo. Genomewide microarray analysis was performed on LV myocardium (Affymetrix). Glomerular hypertrophy was observed in UNX. GFR tended to decrease with a reduction in RBF (S:8±1, Nx:5±1 ml/min, p&lt;0.005). Blood pressure (BP), Na and water excretions were maintained without activation of PRA, aldo or BNP. LVEF and LV diameters were normal. Microarray analysis of LV revealed that 278 genes changed with UNX (1.5 fold, P&lt;0.05) related to cell growth, bone remodeling and muscle contraction (Z value&gt;2). Importantly, Pic Red staining in the LV of UNX revealed greater fibrosis (S:2±0.1, Nx:4±0.4 %, p&lt;0.001). We conclude that mild renal insufficiency initiates myocardial gene responses and fibrosis independent of alterations in the circulating RAAS, BNP, BP, vol overload or systolic dysfunction.
Space-Terrestrial Cooperation Over Spatially Correlated Channels Relying on Imperfect Channel Estimates: Uplink Performance Analysis and Optimization (2022)

A whole suite of innovative technologies and architectures have emerged in response to the rapid growth of wireless traffic. This paper studies an integrated network design that boosts system capacity through cooperation between wireless access points (APs) and a satellite for enhancing the network’s spectral efficiency. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">As for our analytical contributions</i> , upon coherently combing the signals received by the central processing unit (CPU) from the users through the space and terrestrial links, we first mathematically derive an achievable throughput expression for the uplink (UL) data transmission over spatially correlated Rician channels. Our generic achievable throughput expression is applicable for arbitrary received signal detection techniques employed at the APs and the satellite under realistic imperfect channel estimates. A closed-form expression is then obtained for the ergodic UL data throughput, when maximum ratio combining is utilized for detecting the desired signals. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">As for our resource allocation contributions</i> , we formulate the max-min fairness and total transmit power optimization problems relying on the channel statistics for performing power allocation. The solution of each optimization problem is derived in form of a low-complexity iterative design, in which each data power variable is updated relying on a closed-form expression. Our integrated hybrid network concept allows users to be served that may not otherwise be accommodated due to the excessive data demands. The algorithms proposed allow us to address the congestion issues appearing when at least one user is served at a rate below his/her target. The mathematical analysis is also illustrated with the aid of our numerical results that show the added benefits of considering the space links in terms of improving the ergodic data throughput. Furthermore, the proposed algorithms smoothly circumvent any potential congestion, especially in face of high rate requirements and weak channel conditions.
Use of a putative transcriptional regulator gene as target for specific identification of Staphylococcus epidermidis (2006)

As a member of a specialized gene group, putative transcriptional regulator gene serp0107 may be important to Staph. epidermidis adaptation to its niche environment. Further analysis of serp0107 and its related protein may help reveal new insights on the molecular regulation of Staph. epidermidis survival and virulence.
Human MEMs are a distinct high IL-6 producing macrophage subset with anti-inflammatory and radioprotective properties in vivo (2017)

Abstract Macrophages (MØs) can polarize into subsets of “pro-inflammatory” (M1) MØs or “anti-inflammatory” (M2) MØs. Previously we described a unique population of MØs, termed human mesenchymal stem cell (MSC)-educated MØs (MEMs). In this study, we hypothesize that MEMs have potential to attenuate inflammation and promote tissue repair in vivo based on their immunophenotype and secretome. MEMs were generated by isolating monocytes from human peripheral blood and culturing them into MØs, followed by a co-culture with bone marrow-derived MSCs. RNA-Seq analysis showed genes associated with epithelial-mesenchymal transition, collagen formation, tissue development, and cell-cell adhesion were positively correlated with MEMs, while genes associated with oxidative phosphorylation were negatively correlated as compared to M1 MØs. We found increased expression of 8 genes implicated in wound healing, as well as genes representing remodeling enzymes, growth factors and the cytoskeleton. RT-PCR verified MEMs have increased CD206 (p&amp;lt;0.0001), IL-1β (p&amp;lt;0.001), TGFβ (p&amp;lt;0.001) and arginase-1 (p&amp;lt; 0.05), as well as increased IL-6 (p&amp;lt;0.0001) and CD73 (p&amp;lt;0.001) expression. MEMs produced over 4x greater amounts of IL-6 as compared to M2 MØs by ELISA (p&amp;lt;0.001), which could be enhanced with LPS stimulation (p&amp;lt;0.0001) or attenuated by inhibition of COX-2 (p&amp;lt;0.05), arginase-1 (p&amp;lt;0.01) or JAK1/JAK2 (p&amp;lt;0.05). In vivo, MEMs improved survival against lethal GVHD (p&amp;lt;0.01), in part by reducing T cell proliferation (p&amp;lt;0.001). MEMs also enhanced survival of mice from lethal radiation injury (p&amp;lt;0.01), in part by inducing host fibroblast proliferation (p&amp;lt;0.01). MEMs are a unique MØ subset with therapeutic potential for inflammatory disorders.
EFFICIENCY OF THE PHOTOPROCESSES LEADING TO SINGLET OXYGEN (1δg) GENERATION BY α‐TERTHIENYL: OPTICAL ABSORPTION, OPTOACOUSTIC CALORIMETRY AND INFRARED LUMINESCENCE STUDIES* (1990)

The triplet energy of alpha-terthienyl has been determined by heavy atom-induced optical absorption: the value of 39.7 +/- 1.5 kcal/mol is consistent with earlier energy transfer work. Combining this result with calorimetric data from optoacoustic calorimetry indicates that intersystem crossing occurs with at least 90% efficiency in polar and non-polar solvents. The quantum yields for singlet oxygen formation via energy transfer from triplet alpha-terthienyl have been obtained from time-resolved measurements of its IR phosphorescence: these yields are in the 0.6-0.8 range in non-polar and polar (hydroxylic and non-hydroxylic) solvents.
Investigation of Human-Computer Task Markets: Methods and Prototype (2009)

We present research on task markets where automated planning procedures are used to enlist computational and human expertise to jointly contribute to the solution of problems, based on a consideration of the competencies, availabilities, and pricing of the different problem-solving resources. The methods meld the area of human computation with automated reasoning. We describe a prototype that creates plans for harnessing people and computation to perform translation among multiple languages. With the prototype, people with different skills are recruited to refine rough translations generated by a machine translation system. We present details about the hardness of plan generation, provide methods for solving them, and review experiences with the use of a prototype. 1
Data from <i>In Vitro</i> and <i>In Vivo</i> Responses of Advanced Prostate Tumors to PSMA ADC, an Auristatin-Conjugated Antibody to Prostate-Specific Membrane Antigen (2023)

&lt;div&gt;Abstract&lt;p&gt;Prostate-specific membrane antigen (PSMA) is a membrane protein that is overexpressed manifold in prostate cancer and provides an attractive target for therapy. PSMA ADC is an antibody-drug conjugate (ADC) that consists of a fully human anti-PSMA monoclonal antibody conjugated to monomethylauristatin E through a valine-citrulline linker. In this study, the antitumor activity of PSMA ADC was evaluated against a panel of prostate cancer cell lines &lt;i&gt;in vitro&lt;/i&gt; and in a novel &lt;i&gt;in vivo&lt;/i&gt; model of taxane-refractory human prostate cancer. &lt;i&gt;In vitro&lt;/i&gt; cell killing was efficient for cells with abundant PSMA expression (&gt;10&lt;sup&gt;5&lt;/sup&gt; molecules/cell; IC&lt;sub&gt;50&lt;/sub&gt; ≤ 0.022 nmol/L) and 1,000-fold less efficient for cells with undetectable PSMA (IC&lt;sub&gt;50&lt;/sub&gt; &gt; 30 nmol/L). Intermediate potency (IC&lt;sub&gt;50&lt;/sub&gt; = 0.80 nmol/L) was observed for cells with approximately 10&lt;sup&gt;4&lt;/sup&gt; molecules of PSMA per cell, indicating a threshold PSMA level for selective cell killing. Similar &lt;i&gt;in vitro&lt;/i&gt; activity was observed against androgen-dependent and -independent cells that had abundant PSMA expression. &lt;i&gt;In vitro&lt;/i&gt; activity of PSMA ADC was also dependent on internalization and proper &lt;i&gt;N&lt;/i&gt;-glycosylation/folding of PSMA. In contrast, less potent and nonselective cytotoxic activity was observed for a control ADC, free monomethylauristatin E, and other microtubule inhibitors. PSMA ADC showed high &lt;i&gt;in vivo&lt;/i&gt; activity in treating xenograft tumors that had progressed following an initial course of docetaxel therapy, including tumors that were large (&gt;700 mm&lt;sup&gt;3&lt;/sup&gt;) before treatment with PSMA ADC. This study defines determinants of antitumor activity of a novel ADC. The findings here support the clinical evaluation of this agent in advanced prostate cancer. &lt;i&gt;Mol Cancer Ther; 10(9); 1728–39. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Activation Energy and Reaction Rate (2000)

This study provides evidence of abnormal cell membrane architecture and increased HLA class I expression in Iga nephropathy.
rhBMP‐2 has adverse effects on human oral carcinoma cell lines in vivo (2011)

Abstract Objectives/Hypothesis: To establish the relevance of the bone morphogenetic protein (BMP) signaling pathway in human oral squamous cell carcinoma (OSCCA) cell lines and determine if there is a biologic impact of stimulating this pathway with recombinant human (rh) BMP‐2. Study Design: In vitro laboratory investigations and in vivo analysis using an orthotopic animal model for oral cancer. Methods: Gene expression profiles for BMP‐2 and components of the BMP‐signaling pathway were determined using reverse transcriptase‐polymerase chain reaction. In vivo effects were evaluated using Kaplan‐Meier survival analysis and studying histopathologic changes in established tumor xenografts with or without rhBMP‐2 pretreatment. A phosphokinase array was used to detect levels of activation in signaling kinases. Results: The BMP‐2 gene was expressed in 90% of the 30 OSCCA cell lines tested. Gene expression of all components of the BMP‐signaling pathway was highly conserved. Tumor xenografts established with rhBMP‐2–treated cells showed more rapid local growth that resulted in worse animal survival as compared to the control group. These tumors had a more poorly differentiated morphology. Changes in protein kinases suggested interactions of BMP‐2 signaling with the Wnt‐β‐catenin, and Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways. Conclusions: Human OSCCA cell lines frequently express BMP‐2 and all necessary components of the BMP‐signaling pathway. Exogenous treatment of human OSCCA cell lines with rhBMP‐2 prior to engraftment in an orthotopic animal model caused the subsequent tumors to be more locally aggressive with worse survival. Continued caution should be used for considering rhBMP‐2 for reconstruction of bone defects in oral cancer patients.
Table S1 from Mechanism-Based Epigenetic Chemosensitization Therapy of Diffuse Large B-Cell Lymphoma (2023)

&lt;p&gt;Table S1 - PDF file 71K, Chemosensitivity and characteristics of DLBCL cell lines&lt;/p&gt;