gebhart/patrepeval huggingface dataset:
Amino acid substitution in the dopamine D3 receptor as a useful polymorphism for investigating psychiatric disorders (1992)

Dysfunctions in dopaminergic transmission in the brain may occur in several mental disorders. Among the five dopamine receptor genes cloned, the dopamine D3 receptor is expressed almost exclusively in limbic brain areas. The receptor is well recognized by most neuroleptics and is therefore a likely site for antipsychotic drug action and a candidate for being involved in mental disorders. We have detected a point mutation in the gene that creates a Ball restriction enzyme site and leads to a substitution of a Serine by a Glycine residue in the 5′ part of the receptor gene. A method using the polymerase chain reaction was developed to analyze this polymorphism, which was codominantly inherited in 15 nuclear families. To assess allele frequencies in a healthy population, psychiatric interviews were made and 53 individuals without present or earlier psychiatric disturbances were included as controls. A high frequency of both alleles was detected in this population, with a PIC-value (Polymorphism Information Content) of 0.32, which implies a reasonable informativity of the polymorphism in linkage analysis. Use of the polymorphism, in linkage and association studies, should represent a rapid mean to assess the D3 receptor gene as a candidate gene in psychiatric disorders.
Moldable chalcogenide glasses for multispectral imaging in the visible and thermal infrared region (2016)

International audience
Engineering of heart valves using circulating progenitor cells from patients with valvular disease ‐ A feasibility study (2007)

The potential of using progenitor-derived endothelial (ECs) and muscle (SMCs) cells in the tissue-engineering of cardiac valve has been explored in the present study. Circulating progenitor cells were isolated from blood samples of patients with valvular disease. Cells were identified using anti-CD133 and anti-KDR antibodies, expanded and differentiated into ECs and SMCs that were characterized immunohistochemically. ECs stained positive for CD31, VE-cadherin and vWF, and formed capillaries in matrigelTM. SMCs stained positive for α-actin and caldesmon. Collagen matrices prepared form decellularized porcine cardiac valves were used to develop an engineered valve. When seeded on to these matrices, ECs and SMCs attached, proliferated and formed defined cell layers. The engineered valve showed similar biomechanical properties as normal valve tissues. The degree of coagulation was minimal in cell seeded valve surfaces, when compared to unseeded matrices. This study shows the feasibility of isolating and culturing progenitor cells from patients that could be differentiated into ECs and SMCs. Progenitor-derived cells retain their characteristcs and could be used for engineering of cardiac valves for autologous implantation.
Laparoscopic Transperitoneal Nephrectomy for Renal Cancer: The University of California, Irvine, Technique (2011)

The first laparoscopic nephrectomy for a renal tumor was performed 20 years ago at Washington University in St. Louis. Since that time, laparoscopic radical nephrectomy has become a standard of care when dealing with large renal tumors or other renal cancers not amenable to partial nephrectomy or ablative therapy. In the following article and videotape, the surgical technique of a laparoscopic radical nephrectomy is traced and the method of approach is documented. This approach is the one that is currently used at the University of California, Irvine, and reflects the authors' preferred operative technique.
Modeling cumulative overall prevention efficacy for the VRC01 phase 2b efficacy trials (2018)

The Antibody Mediated Prevention trials are assessing whether intravenously-administered VRC01 (10 mg/kg or 30 mg/kg vs placebo) can prevent HIV infection. In a modeling exercise, we used two models to predict the overall prevention efficacy (PE) of each VRC01 dose in preventing HIV infection. For the first per-exposure PE model, parameters were estimated from studies where nonhuman primates (NHPs) were administered high-dose intra-rectal simian-human immunodeficiency virus challenge two days post-VRC01 infusion at various dosages ("NHP model"). To account for the fact that humans may require greater VRC01 concentration to achieve the same level of protection, we next assumed that a 5-fold greater VRC01 serum concentration would be needed to provide the same level of per-exposure PE as seen in the NHP data ("5-fold model"). For the 10 mg/kg regimen, the 5-fold and NHP models predict an overall PE of 37% and 64%, respectively; for the 30 mg/kg regimen, the two models predict an overall PE of 53% and 82%, respectively. Our results support that VRC01 may plausibly confer positive PE in the AMP trials. Given the lack of available knowledge and data to verify the assumptions undergirding our modeling framework, its quantitative predictions of overall PE are preliminary. Its current main applications are to supplement decisions to advance mAb regimens to efficacy trials, and to enable mAb regimen ranking by their potential for PE in humans.
Object Tracking in Video Pictures based on Image Segmentation and Pattern Matching (2005)

We propose a novel algorithm for object tracking in video pictures, based on image segmentation and pattern matching. With image segmentation, we can detect all objects in images, whether they are moving or not. Using the image segmentation results of successive frames, we exploit pattern matching in a simple feature space for tracking the objects. Consequently, the proposed algorithm can be applied to multiple moving and still objects, even in the case of a moving camera. We describe the algorithm in detail and perform simulation experiments on object tracking which verify the tracking algorithm's efficiency. VLSI implementation of the proposed algorithm is possible.
Earthshine and the Earth's albedo: 1. Earthshine observations and measurements of the lunar phase function for accurate measurements of the Earth's Bond albedo (2003)

We have been making sustained observations of the earthshine from Big Bear Solar Observatory in California since late 1998. We also have intermittent observations from 1994–1995. We have reinvigorated and modernized a nearly forgotten way of measuring the Earth's albedo, and hence its energy balance, previously studied by A. Danjon and his followers for about 25 years early in the last century using their observations of the earthshine from France. This is the first in a series of papers covering observations and simulations of the Earth's reflectance from photometric and spectral observations of the Moon. Here, we develop a modern method of measuring, instantaneously, the large‐scale reflectance of the Earth. From California we see the Moon reflecting sunlight from the third of the Earth to the west of us in our evening (before midnight, which is during the Moon's rising phase) and from the third of the Earth to our east in our morning (after midnight, which is during the Moon's declining phase). We have precisely measured the scattering from the Moon as a function of lunar phase, which enables us to measure, in a typical night's observations, the Earth's reflectance to an accuracy of 2.0% (equivalent to measuring the Earth's emission temperature to ∼0.8 K). We have also identified the lunar phase function as the major source of discrepancy between Danjon's estimates of the albedo and more recent measurements. The albedo is due to the interplay of cloud cover and different landscapes.
Synthesis and some pharmacological properties of tocinoic acid and deaminotocinoic acid (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and some pharmacological properties of tocinoic acid and deaminotocinoic acidVictor J. Hruby, Clark W. Smith, David K. Linn, Martha F. Ferger, and Vincent Du VigneaudCite this: J. Am. Chem. Soc. 1972, 94, 15, 5478–5480Publication Date (Print):July 1, 1972Publication History Published online1 May 2002Published inissue 1 July 1972https://pubs.acs.org/doi/10.1021/ja00770a052https://doi.org/10.1021/ja00770a052research-articleACS PublicationsRequest reuse permissionsArticle Views62Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Heat Transfer Measurements inside Narrow Channels with Ribs and Trenches (2017)

Detailed heat transfer coefficient distributions are obtained for high aspect ratio (width/height = 12.5) duct with rib and trench enhancement features oriented normal to the coolant flow direction. A transient thermochromic liquid crystal technique has been used to experimentally measure heat transfer coefficients from which Nusselt numbers are calculated on the duct surface featuring heat transfer enhancement features. Reynolds number (calculated based on duct hydraulic diameter) ranging from 7100 to 22400 were experimentally investigated. Detailed measurements of heat transfer provided insight into the role of protruding ribs and trenches on the fluid dynamics in the duct. Experimentally obtained Nusselt numbers are normalized by Dittus-Boelter correlation for developed turbulent flow in circular duct. The triangular trenches provide heat transfer enhancement ratios up to 1.9 for low Reynolds numbers. The in-line rib configuration shows similar levels to the trench whereas staggered rib configuration provides heat transfer enhancement ratios up to 2.2 for a low Reynolds number of 7100.
End‐to‐end collaboration to transform biopharmaceutical development and manufacturing (2021)

An ambitious 10-year collaborative program is described to invent, design, demonstrate, and support commercialization of integrated biopharmaceutical manufacturing technology intended to transform the industry. Our goal is to enable improved control, robustness, and security of supply, dramatically reduced capital and operating cost, flexibility to supply an extremely diverse and changing portfolio of products in the face of uncertainty and changing demand, and faster product development and supply chain velocity, with sustainable raw materials, components, and energy use. The program is organized into workstreams focused on end-to-end control strategy, equipment flexibility, next generation technology, sustainability, and a physical test bed to evaluate and demonstrate the technologies that are developed. The elements of the program are synergistic. For example, process intensification results in cost reduction as well as increased sustainability. Improved robustness leads to less inventory, which improves costs and supply chain velocity. Flexibility allows more products to be consolidated into fewer factories, reduces the need for new facilities, simplifies the acquisition of additional capacity if needed, and reduces changeover time, which improves cost and velocity. The program incorporates both drug substance and drug product manufacturing, but this paper will focus on the drug substance elements of the program.
High Carrier Mobility of 3.8 cm$^{2}$ V$^{-1}$ s$^{-1}$ in Polydiacetylene Thin Films Polymerized by Electron Beam Irradiation (2011)

The highest carrier mobility of polydiacetylene (PDA) thin films in field-effect transistors has been limited to less than 0.8 cm2 V-1 s-1, although the main chain conduction should show higher carrier mobility potentially. We revealed that the cause of the low carrier mobility is due to the presence of local upheaval regions generated by the volume change through the polymerization process of diacetylene monomers. In order to suppress the occurrence of the upheaval regions, we found that electron beam (EB) irradiation is effective, resulted in the highest carrier mobility of µmax = 3.8 cm2 V-1 s-1.
Elevated surum creatine kinase activity in adolescent psychiatric inpatients on admission (1998)

Studies in adults have indicated a significant relationship between high serum creatine kinase levels on admission and acute psychosis. However, data on children are sparse. The files of 183 hospitalized children and adolescents (93 boys, 90 girls) with severe psychiatric disorders were reviewed for serum creatine kinase activity on admission, psychomotor agitation, Clinical Global Impression Score, need for intramuscular injection, number of neuroleptic medications and presence of neuroleptic malignant syndrome. Serum creatine kinase levels > 201 IU/ml were considered abnormal. Boys had significantly higher creatine kinase activity than girls. Division of the cohort by diagnosis yielded significantly higher levels in those with schizophrenia, affective disorders and mental retardation. Higher levels were also associated with higher Clinical Global Impression score on admission, use of injections and physical restraint, and nonresponse to neuroleptic medication. There were no cases of neuroleptic malignant syndrome. This first large-scale investigation of serum creatine kinase activity in young psychiatric inpatients shows a significant association between high creatine kinase activity and acute psychosis, similar to that in adults. Furthermore, high creatine kinase levels on admission are predictive of the severity of the psychosis, but are not associated with neuroleptic malignant syndrome. Because psychotic adolescents with high admission creatine kinase levels tend to be nonresponders, clinicians should consider the early use of atypical antipsychotics in this subgroup.
Isoindoline‐Based Nitroxides as Bioresistant Spin Labels for Protein Labeling through Cysteines and Alkyne‐Bearing Noncanonical Amino Acids (2019)

Electron paramagnetic resonance (EPR) spectroscopy in combination with site-directed spin labeling (SDSL) is a powerful tool in protein structural research. Nitroxides are highly suitable spin labeling reagents, but suffer from limited stability, particularly in the cellular environment. Herein we present the synthesis of a maleimide- and an azide-modified tetraethyl-shielded isoindoline-based nitroxide (M- and Az-TEIO) for labeling of cysteines or the noncanonical amino acid para-ethynyl-l-phenylalanine (pENF). We demonstrate the high stability of TEIO site-specifically attached to the protein thioredoxin (TRX) against reduction in prokaryotic and eukaryotic environments, and conduct double electron-electron resonance (DEER) measurements. We further generate a rotamer library for the new residue pENF-Az-TEIO that affords a distance distribution that is in agreement with the measured distribution.
Compressed SRv6 SID List Analysis (1998)

Several mechanisms have been proposed to compress the SRv6 SID list.
This document analyzes each mechanism with regard to the requirements
stated in the companion requirements document.
Adaptive step size LMS for ECG artefact reduction during MR (2015)

International audience
Recent trends in CMOS reliability: From individual traps to circuit simulations (2011)

Summary form only given. In recent years, researchers are building models relying on a wide variety of data that can be extracted from software repositories, concerning for example characteristics of source code changes, or be related to bug introduction and fixing. Software repositories also contain a huge amount of non-structured information, often expressed in natural language, concerning communication between developers, as well as tags, commit notes, or comments developers produce during their activities. This keynote illustrates, on the one hand, how explanatory or predictive models build upon software repositories could be enhanced by integrating them with the analysis of communication among developers. On the other hand, the keynote warns agains perils in doing that, due to the intrinsic imprecision and incompleteness of such a textual information, and explains how such problems could, at least, be mitigated.
Back to the Source: an Online Approach for Sensor Placement and Source Localization (2017)

Source localization, the act of finding the originator of a disease or rumor in a network, has become an important problem in sociology and epidemiology. The localization is done using the infection state and time of infection of a few designated sensor nodes; however, maintaining sensors can be very costly in practice. We propose the first online approach to source localization: We deploy a priori only a small number of sensors (which reveal if they are reached by an infection) and then iteratively choose the best location to place new sensors in order to localize the source. This approach allows for source localization with a very small number of sensors; moreover, the source can be found while the epidemic is still ongoing. Our method applies to a general network topology and performs well even with random transmission delays.
Synthesis of functionalized amino acid derivatives as new pharmacophores for designing anticancer agents (2008)

A new series of functionalized amino acid derivatives N-substituted 1-N-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyl-5-oxazolidine carboxamide (1-17) and 1-N-substituted-3-amino-2-hydroxy-3-phenylpropane-1-carboxamide (18-34) were synthesized and evaluated for their in vitro cytotoxicity against human cancer cell lines. Compound 6 has shown interesting cytotoxicity (IC(50) = 5.67 microm) in ovarian cancer, while compound 10 exhibited promising cytotoxicity in ovarian (IC(50) = 6.1 microm) and oral (IC(50) = 4.17 microm) cancers. These compounds could be of use in designing new anti-cancer agents.
THE EFFECTS OF HEATSTROKE ON THE FUNCTION AND STRUCTURE OF THE KIDNEY (1967)

Journal Article THE EFFECTS OF HEATSTROKE ON THE FUNCTION AND STRUCTURE OF THE KIDNEY Get access M. C. KEW, M. C. KEW Department of Medicine and Renal Unit, Johannesburg Hospital and University of the Witwatersrand, and Sourth African Institute for Medical ResearchJohannesburg Search for other works by this author on: Oxford Academic PubMed Google Scholar C. ABRAHAMS, C. ABRAHAMS Department of Medicine and Renal Unit, Johannesburg Hospital and University of the Witwatersrand, and Sourth African Institute for Medical ResearchJohannesburg Search for other works by this author on: Oxford Academic PubMed Google Scholar N. W. LEVIN, N. W. LEVIN Department of Medicine and Renal Unit, Johannesburg Hospital and University of the Witwatersrand, and Sourth African Institute for Medical ResearchJohannesburg Search for other works by this author on: Oxford Academic PubMed Google Scholar H. C. SEFTEL, H. C. SEFTEL Department of Medicine and Renal Unit, Johannesburg Hospital and University of the Witwatersrand, and Sourth African Institute for Medical ResearchJohannesburg Search for other works by this author on: Oxford Academic PubMed Google Scholar A. H. RUBENSTEIN, A. H. RUBENSTEIN Department of Medicine and Renal Unit, Johannesburg Hospital and University of the Witwatersrand, and Sourth African Institute for Medical ResearchJohannesburg Search for other works by this author on: Oxford Academic PubMed Google Scholar I. BERSOHN I. BERSOHN Department of Medicine and Renal Unit, Johannesburg Hospital and University of the Witwatersrand, and Sourth African Institute for Medical ResearchJohannesburg Search for other works by this author on: Oxford Academic PubMed Google Scholar QJM: An International Journal of Medicine, Volume 36, Issue 3, July 1967, Pages 277–300, https://doi.org/10.1093/oxfordjournals.qjmed.a067113 Published: 01 July 1967 Article history Received: 20 January 1967 Published: 01 July 1967
Architecture Studies in Parallel Optoelectronic Computing. (1997)

Abstract : The 3D two-photon memory was found to be well suited for very large databases with low write requirements because of its potential capacity. raw bandwidth and random access capability. It was determined that performance can be significantly improved by utilizing and accessing feature termed bi-orthogonal access. a feature which allows both record and field parallel access to be supported simultaneously A metric termed bit retrieval efficiency was devised to evaluate the optimality of relational database operations performed with a bi-orthogonally accessed 3D optical memory. The results of this analysis I indicate that the throughput and the random access capability of a memory both affect the performance of relational database machines. A shortcoming that all massively parallel access optical memories have. in terms of this applications is that an entire page of records has to be retrieved even if only one record is desired. From this point they appear to have reduced random access capabilities. We have focused on the theoretical feasibility of obtaining 2-D photonic bandgap from a two-dimensional honeycomb dielectric lattice structure. with a particular emphasis on the effect of having a finite rod length. We have also started investigating the impact of the inclusion of active device structures (e.g.. VCSELs) into the photonic crystals.
Assessing data mining results via swap randomization (2007)

The problem of assessing the significance of data mining results on high-dimensional 0--1 datasets has been studied extensively in the literature. For problems such as mining frequent sets and finding correlations, significance testing can be done by standard statistical tests such as chi-square, or other methods. However, the results of such tests depend only on the specific attributes and not on the dataset as a whole. Moreover, the tests are difficult to apply to sets of patterns or other complex results of data mining algorithms. In this article, we consider a simple randomization technique that deals with this shortcoming. The approach consists of producing random datasets that have the same row and column margins as the given dataset, computing the results of interest on the randomized instances and comparing them to the results on the actual data. This randomization technique can be used to assess the results of many different types of data mining algorithms, such as frequent sets, clustering, and spectral analysis. To generate random datasets with given margins, we use variations of a Markov chain approach which is based on a simple swap operation. We give theoretical results on the efficiency of different randomization methods, and apply the swap randomization method to several well-known datasets. Our results indicate that for some datasets the structure discovered by the data mining algorithms is expected, given the row and column margins of the datasets, while for other datasets the discovered structure conveys information that is not captured by the margin counts.