gebhart/patrepeval huggingface dataset:
Iron content correlates with peroxidase activity in cysteamine-induced astroglial organelles. (1992)

A subpopulation of astrocytes in periventricular brain regions and in cysteamine-treated neuroglial cultures contains cytoplasmic granules that exhibit an affinity for Gomori stains, orange-red autofluorescence, and non-enzymatic peroxidase activity. The autofluorescence and pseudoperoxidase activity are consistent with the presence of porphyrins and heme iron, respectively. In the present study, we employed diaminobenzidine cytochemistry, transmission electron microscopy, and energy-dispersive X-ray microanalysis (electron microprobe) in an attempt to correlate fine structure with the peroxidase activity and elemental composition of the cysteamine-induced inclusions in cultured astrocytes. In osmicated preparations, these membrane-bound inclusions varied greatly in size, were round or ovoid in shape, and exhibited an intensely electron-dense granular matrix. In non-osmicated preparations, many inclusions exhibited internal membranous partitions producing complex subcompartmentalization. Diaminobenzidine reaction product, indicative of endogenous peroxidase activity, was occasionally observed distributed diffusely throughout the granule matrix. More commonly, peroxidase activity was restricted to specific intraorganellar compartments. Elemental iron was detected in the inclusions by electron microprobe analysis. The presence and concentration of iron in these organelles correlated closely with the presence and intensity of diaminobenzidine staining, suggesting that redox-active iron mediates the pseudoperoxidase reactions in these cells. Cysteamine-induced derangements of porphyrin-heme biosynthesis may be responsible for the proliferation of iron-containing gliosomes in these astrocytes.
Platelet-Rich Plasma Promotes the Proliferation of Human Muscle Derived Progenitor Cells and Maintains Their Stemness (2013)

Human muscle-derived progenitor cells (hMDPCs) offer great promise for muscle cell-based regenerative medicine; however, prolonged ex-vivo expansion using animal sera is necessary to acquire sufficient cells for transplantation. Due to the risks associated with the use of animal sera, the development of a strategy for the ex vivo expansion of hMDPCs is required. The purpose of this study was to investigate the efficacy of using platelet-rich plasma (PRP) for the ex-vivo expansion of hMDPCs. Pre-plated MDPCs, myoendothelial cells, and pericytes are three populations of hMDPCs that we isolated by the modified pre-plate technique and Fluorescence Activated Cell Sorting (FACS), respectively. Pooled allogeneic human PRP was obtained from a local blood bank, and the effect that thrombin-activated PRP-releasate supplemented media had on the ex-vivo expansion of the hMDPCs was tested against FBS supplemented media, both in vitro and in vivo. PRP significantly enhanced short and long-term cell proliferation, with or without FBS supplementation. Antibody-neutralization of PDGF significantly blocked the mitogenic/proliferative effects that PRP had on the hMDPCs. A more stable and sustained expression of markers associated with stemness, and a decreased expression of lineage specific markers was observed in the PRP-expanded cells when compared with the FBS-expanded cells. The in vitro osteogenic, chondrogenic, and myogenic differentiation capacities of the hMDPCs were not altered when expanded in media supplemented with PRP. All populations of hMDPCs that were expanded in PRP supplemented media retained their ability to regenerate myofibers in vivo. Our data demonstrated that PRP promoted the proliferation and maintained the multi-differentiation capacities of the hMDPCs during ex-vivo expansion by maintaining the cells in an undifferentiated state. Moreover, PDGF appears to be a key contributing factor to the beneficial effect that PRP has on the proliferation of hMDPCs.
Room-Temperature Electronically-Controlled Ferromagnetism at the LaAlO3/SrTiO3 Interface (2013)

Reports of emergent conductivity, superconductivity, and magnetism at oxide interfaces have helped to fuel intense interest in their rich physics and technological potential. Here we employ magnetic force microscopy to search for room-temperature magnetism in the well-studied LaAlO3/SrTiO3 system. Using electrical top gating to deplete electrons from the oxide interface, we directly observe an in-plane ferromagnetic phase with sharply defined domain walls. Itinerant electrons, introduced by a top gate, align antiferromagnetically with the magnetization, at first screening and then destabilizing it as the conductive state is reached. Subsequent depletion of electrons results in a new, uncorrelated magnetic pattern. This newfound control over emergent magnetism at the interface between two non-magnetic oxides portends a number of important technological applications.
[4 + 2], [2 + 2], and Carbene addition reactions involving cyclohexa-3,5-diene-cis-1,2-diol derivatives (1990)

The reactions of cis-1,2-isopropylidenedioxycyclohexa-3,5-diene (1) with two N-substituted maleimides, diphenylketene, dichlorocarbene and ethoxycarbonylcarbene are described. Selected reactions of the 3-triflucromsthyl-(2) and 3-fluoro-(3) analogues with these reagents are also reported.
Metal-PZT Composite Piezoelectric Transducers and Ultrasonic Motors (2007)

Rotary and linear ultrasonic motors were developed in the present paper using metal-PZT composite piezoelectric stator transducer configuration. The transducer consists of a concentric PZT tube and a metal tube, which structurally improve the reliability of the stator transducer. The developed transducer can provide a free vibration velocity of 0.9 m/s under 100 Vp-p at the resonant state. The rotary motor and linear motor use the developed transducer as the driving component, which produces the rotational motion to drive the motor. The rotary motor is able to achieve about 700 rpm no-load speed, above 2 mNm torque, maximum 70 mW output power and 50% efficiency under driving voltage of 80 Vp-p. The linear motor produces rotational motion and linear motion simultaneously. The linear speed of 5 mm/s can be achieved under the driving voltage of 50 Vp-p under no-load state. Under the loaded state, maximum 8 N load has been observed to be moved by the motor at a speed of 0.6 m/s. The maximum output power and efficiency of the linear motor are 9 mW and 11%, respectively.
Tangible interaction with light in the IoT (2016)

Interacting with digital lighting systems opens new opportunities and challenges, especially when those systems are connected to the Internet of Things (IoT). This workshop aims at investigating richer interactions with interconnected lights. We strive for interactions that happen in our everyday environments and that go beyond not only swiping and tapping on a screen, but also the mere tangible switch. This workshop will be an opportunity to discuss and practice novel interactions with light, exploring human bodily and cognitive skills to grasp better the ephemerality of light and of the IoT.
Sulfhydrolysis of Acyl Ketene Dithioacetals: A Convenient Synthesis of β-Oxodithioesters (1999)

Abstract β-Oxodithioesters are obtained in good yields from acyl ketenedithioacetals on treatment with hydrogen sulphide in the presence of boron trifluoride eiherate in refluxing dioxane
All fiber based coherent THz magneto-spectrometer (2012)

In this paper we present a compact THz Magneto-spectrometer based on an all-fiber OSCAT system with rapid scan mode. We investigate properties of graphite and p-Ge samples in magnetic fields up to 10T.
Validation of a new non-invasive blood pressure measurement method on mice via pulse wave propagation time measurement on a cuff (2011)

In the present article, we describe the validation of a new&#13;\nnon-invasive method for measuring blood pressure (BP)&#13;\nwhich also enables to determine the three BP values: systolic,&#13;\ndiastolic and mean value. Our method is based on the pulse&#13;\ntransit time (PTT) measurement along an artery directly at&#13;\nthe BP cuff. The accuracy of this method was evaluated by&#13;\ncomparison with the direct simultaneous measurement of&#13;\nblood pressure from 40 anesthetized female mice. Close correlation&#13;\nbetween the gained data from these two methods was&#13;\nobserved.
A common variant in the MTNR1b gene is associated with increased risk of impaired fasting glucose (IFG) in youth with obesity (2015)

It has been shown for the first time in obese youth that the MTNR1B variant is associated with an increased risk of IFG.
A Practical Approach to Hybrid Beamforming for 5G Wi-Fi Systems (2021)

The conventional implementation of large-scale antenna arrays with full digital antenna (FDA) beamforming is not practical due to complexity, high cost and power consumption. Hybrid beamforming (HBF) architecture combines digital beamforming in the baseband and analog beamforming in the RF part using low-cost phase shifters. This architecture helps reduce the number of RF chains and the system complexity with an acceptable performance loss. In this paper, we investigate the effectiveness of the HBF technology in application to the upcoming 5G Wi-Fi IEEE standard 802.11be. A detailed comparative analysis of different antenna array configurations and beamforming schemes suggests the most cost-efficient HBF scheme based on a modular antenna array (MAA). This practical HBF-MAA scheme with a 16-element antenna and only 4 RF chains demonstrates in line-of-sight channels the data rates close to the expensive 16-element FDA scheme and significantly outperforms a 4-element FDA which has equivalent complexity.
Non-invasive measurement of pyruvate and glucose uptake and lactate production by sigle human preimplantation embryos (1990)

The consumption of pyruvate and glucose and the production of lactate by 40 single human preimplantation embryos has been measured using a non-invasive technique. Twelve of the embryos showed abnormal fertilization. Of the 28 normally fertilized embryos, nine (32%) developed to the blastocyst stage in culture while the remainder degenerated or arrested during cleavage. In the normal embryos, pyruvate uptake exceeded that of glucose in the early developmental stages (days 2-5 post-insemination) before glucose became the predominant substrate in the blastocyst (day 6). Considerable quantities of lactate were formed throughout development, rising from a value of 43.6 pmol/embryo/h on day 2.5 to 95.4 pmol/embryo/h on day 5.5. The values of pyruvate and glucose uptake and lactate production of those embryos which arrested were below those which developed normally. On the basis that one mole of glucose can give rise to two moles of lactate, only 50% of the lactate produced could be accounted for in terms of glucose uptake from the medium. This figure rose to 90% in the blastocyst. The remaining lactate must be derived from endogenous sources, most probably glycogen. It is proposed that the high production of lactate by human preimplantation embryos in vitro is an adaptation to the conditions of culture.
The use of 1H NMR for yield determination in the regioselective epoxidation of squalene (2005)

Abstract 1 H NMR can be used to determine the epoxide yield rapidly in the oxidation of squalene. Moreover, unequivocal distinction can be made between internal and terminal epoxide bonds. To underline the power of this technique, different stoichiometric and catalytic epoxidation procedures were carried out using squalene as substrate. They were characterized in terms of substrate conversion and regioselectivity of the epoxide fraction.
Analgesia with peripheral nerve stimulation: Absence of a peripheral mechanism (1983)

Electrical stimulation of peripheral nerve can bring pain relief to patients suffering from intractable pain of peripheral origin. Some investigators believe that the mechanism responsible for this effect is located in the central nervous system (CNS) while others suggest that it is a peripheral one involving a conduction block in small diameter afferent fibers, thereby preventing the arrival of nociceptive information to the CNS. To determine which of these mechanisms was more likely to be responsible for producing this effect we studied 9 patient volunteers who sought relief from severe chronic, post-traumatic pain in their extremities by stimulation of electrode cuffs implanted on their peripheral nerves. Using normalized stimulation procedures on human nerve and reapplying them to peripheral nerve of the cat, we were able to reconstruct, to a degree of accuracy not previously described in human subjects, the functional events occurring in nerve at the site of stimulation when patients reported pain relief. This effect was reliably induced in 7 of our 9 subjects with a mean relative stimulus intensity of 1.3T, a value insufficient to activate Aδ or C fibers. No conduction failure appeared in A fibers of the cat with prolonged stimulation at 75 Hz at intensities 4 times greater than those causing pain relief in man. Under conditions governed by patient choice there was no evidence that nerve block accounted for the effect. The mechanism appears to depend upon normal conduction of action potentials in large diameter fibers.
A NEW MOBILE ELECTRON ACCELERATOR FOR INTRA OPERATIVE ELECTRON RADIATION THERAPY (2014)

A demonstrator of a new, highly mobile, robotized linear electron accelerator for Intra Operative Electron Radiation Therapy (IOERT) is under construction at National Centre for Nuclear Studies. In an IOERT treatment, a high dose of electron radiation is delivered in a single fraction directly to an exposed location after tumor ablation during oncological surgery. Due to the fact that the tumor can be located anywhere in the body, a high maneuverability of the accelerator and its adaptability to anatomical conditions are required. Moreover, since the treatment is usually executed in an unshielded operation room, the radiation protection issues are of principal importance. To assure safety of the patient and medical personnel, the therapeutic head is designed to constrain the radiation to the volume of the tumor lodge while minimizing leakage and stray radiation. For these reasons, construction of accelerators for IOERT differs considerably from the construction of linear electron accelerators for external beam radiation therapy. This paper presents some challenges and solutions in construction of the accelerator and in particular its therapeutic head with beam forming system.
Multi-modal Potentiation of Oncolytic Virotherapy by Vanadium Compounds (2017)

Oncolytic viruses (OV) are an emerging class of anticancer bio-therapeutics that induce antitumor immunity through selective replication in tumor cells. However, the efficacy of OVs as single agents remains limited. We introduce a strategy that boosts the therapeutic efficacy of OVs by combining their activity with immuno-modulating, small molecule protein tyrosine phosphatase inhibitors. We report that vanadium-based phosphatase inhibitors enhance OV infection in vitro and ex vivo, in resistant tumor cell lines. Furthermore, vanadium compounds increase antitumor efficacy in combination with OV in several syngeneic tumor models, leading to systemic and durable responses, even in models otherwise refractory to OV and drug alone. Mechanistically, this involves subverting the antiviral type I IFN response toward a death-inducing and pro-inflammatory type II IFN response, leading to improved OV spread, increased bystander killing of cancer cells, and enhanced antitumor immune stimulation. Overall, we showcase a new ability of vanadium compounds to simultaneously maximize viral oncolysis and systemic anticancer immunity, offering new avenues for the development of improved immunotherapy strategies.
Forming-Free $\hbox{TiO}_{2}$-Based Resistive Switching Devices on CMOS-Compatible W-Plugs (2011)

In this letter, bipolar resistive switching in TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -based memory elements deposited on CMOS-compatible W-plugs is examined. By comparison with a Pt/TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /W resistive switch, it is demonstrated that the use of a 5-nm-thin Ti or W interlayer between the Pt top electrode and the 25-nm TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> film is the key step for the release from the necessity of electroforming, which is usually required in redox-based resistive switching elements. This is explained by an intentional barrier lowering between the oxide and the electrode materials. The forming-free characteristics on W-plugs make the devices very attractive for future nonvolatile memory applications.
Custom VLSI ASIC for automotive applications with recurrent networks (2002)

Demands on the performance of vehicle control and diagnostic systems are steadily increasing as a consequence of stiff global competition and government mandates. Neural networks provide a means of creating control and diagnostic strategies that will help in meeting these demands efficiently and robustly. This paper describes a VLSI design that permits such networks to be executed in real time as well as the application in misfire detection, that served as a focus for the collaborative effort.
Multi-Rate TCP Video Streaming for Client Heterogeneity (2008)

본 논문에서는 동일 서버를 통하여 이종 클라이언트들에게 동시에 비디오 스트리밍 서비스를 제공하는 환경에서 서비스 품질 보장을 위한 스트리밍 알고리듬을 제안하였다 . 이러한 환경에서 네트워크 자원을 효율적으로 사용하고 신뢰성 있는 전송을 수행하기 위해 전송계층 프로토콜로서 TCP를 사용 하여 비디오 스트리밍 서비스를 제공하면 각 스트리밍 세션들을 위한 TCP 커넥션들은 링크 대역폭을 공평하게 공유하게 된다. 이로 인해 상대적으로 높은 비트레이트를 요구하는 스트리밍 클라이언트는 재생버퍼 언더런과 같은 품질저하를 겪게 될 수 있는데 본 논문에서는 이러한 문제를 해결하기 위하여 각 클라이언트들의 요청 대역폭과 재생버퍼 크기를 고려하여 적응적으로 다중 TCP 커넥션을 사용하는 방안을 제안하였다. 제안 알고리듬을 통하여 이종 클라이언트들의 환경에 맞는 스트리밍 대역폭을 보장할 수 있게 됨을 실험결과를 통하여 확인 할 수 있다 . Key Words : 멀티레이트 비디오, 이종 단말 지원, TCP 스트리밍, QoSABSTRACT
HMM-based speech enhancement using harmonic modeling (2002)

This paper describes a technique for reduction of non-stationary noise in electronic voice communication systems. Removal of noise is needed in many such systems, particularly those deployed in harsh mobile or otherwise dynamic acoustic environments. The proposed method employs state-based statistical models of both speech and noise, and is thus capable of tracking variations in noise during sustained speech. This work extends the hidden Markov model (HMM) based minimum mean square error (MMSE) estimator to incorporate a ternary voicing state, and applies it to a harmonic representation of voiced speech. Noise reduction during voiced sounds is thereby improved. Performance is evaluated using speech and noise from standard databases. The extended algorithm is demonstrated to improve speech quality as measured by informal preference tests and objective measures, to preserve speech intelligibility as measured by informal diagnostic rhyme tests, and to improve the performance of a low bit-rate speech coder and a speech recognition system when used as a pre-processor.
A Super Stretchable Organic Thin-Film Diodes Network That Can Be Embedded Into Carbon Fiber Composite Materials for Sensor Network Applications (2016)

The ability to create a super stretchy sensor network with massive integrated sensors and embed it into carbon fiber composite materials will be very essential to enable self-sensing intelligent engineering materials. However, challenges arise on how to integrate thin-film switching devices into a super stretchy sensor network that could survive in the carbon fiber composite embedding process. In addition, ensuring good insulation between the sensor network and the conductive carbon fiber composite materials is also a challenge. Here, we report techniques to integrate thin-film organic diodes into a super stretchy sensor network through a high-resolution CMOS/MEMS fabrication process. We also demonstrate the functionalities of the network after it is embedded into carbon fiber composite materials.
Integration of light and atom optics on an atom chip (2004)

The whole business of quantum computing with neutral atoms requires accurate preparation and control of their quantum states. The envisioned procedure of preparing and operating an atom chip quantum processor involves two main tools at all its stages: quasi‐static electro‐magnetic fields to provide taylored potentials for trapping and guiding atomic qubits and light optical elements for initialisation, gate operation and read‐out. Our vision is to implement microoptics directly on the atom chip. A large scale quantum processor will probably involve microscale structures such as waveguides or photonic crystals. As a final goal even the light sources themselves (diode lasers) might be integrated on the chip. The miniaturisation of optical elements already is a rapidly growing field driven by the telecommunication boom. We hope to adapt these techniques to develope an atom optical toolbox for Quantum Information Processing. Our first experiments aim at the detection of few or even single atoms in miniaturized traps using optical fibres. Two single mode fibres will be mounted on an atom chip with a small gap between the facets. Light that is sent through the fibres will be absorbed by the atoms leading to a decreased output intensity. In order to enhance the coupling between light and atom, the two fibres should form a cavity. Each time an atom enters the cavity, the output intensity will decrease. Here we present our ongoing experiments, where we try to build a fibre cavity on a chip serving as a single atom detector. The concepts will be introduced, theoretical estimates for expectable signals will be presented and first setups will be shown. Beyond this we will discuss future perspectives of this technology.
Energy saving: Scaling network energy efficiency faster than traffic growth (2013)

As the mobile traffic is expected to continue its exponential growth in the near future, energy efficiency has gradually become a must criterion for wireless network design. Three fundamental questions need to be answered before the detailed design could be carried out, namely what energy efficiency network is, where the energy efficiency improvement may come, how the energy efficiency evaluation of a whole mobile network could be conducted. In this paper, we target to shed a light on the answers of the three questions by introducing the bottom-up energy efficiency evaluation methodology for large networks with the combination of different areas and time periods, as well as the basic traffic, deployment, and power models that will be applied therein. Moreover, we shall illustrate where the overall energy saving gain may come by analyzing the power-traffic relation and the three research projects in the GreenTouch Mobile WG.