gebhart/patrepeval huggingface dataset:
Durability of complete response after blinatumomab therapy for refractory/relapsed aggressive B-cell non-Hodgkin lymphoma. (2019)

e19041 Background: Achieving durable response in patients (pts) with relapsed/refractory (R/R) aggressive B-cell lymphoma (B-NHL) is challenging. Blinatumomab, a bispecific T-cell engager (BiTE) immunotherapy targeting CD19-expressing cancer cells, has shown promising efficacy in pts with R/R aggressive B-NHL. We report the durability of complete response (DOCR) in pts treated with blinatumomab. Methods: The DOCR in pts with R/R aggressive B-NHL responding to blinatumomab was assessed using data from two phase 2 studies (study 1 [N = 25], NCT01741792; study 2 [N = 41], NCT02910063) in pts with R/R aggressive B-NHL. CR was assessed using Cheson (study 1) and Lugano (study 2) criteria. Time-to-event variables were analyzed using the Kaplan-Meier (KM) method. Results: Baseline pt characteristics in the pooled analysis were: median age 59 years (range, 4177); 54% men; 54% treatment refractory; median 2 lines of prior therapy (range, 17); and 15% with prior autologous hematopoietic stem cell transplant. Of 25 pts treated with blinatumomab in study 1, 4 (16%) evaluable pts achieved CR. Of 41 pts treated with blinatumomab in study 2, 9 (22%) achieved CR. Median DOCR was not reached (Table). At a median follow-up of 9.1 months in the pooled analysis, 3 pts (23%) had relapsed (study 1, n = 2 [50%]; study 2, n = 1 [11%]). At 12 and 18 months, the KM probability of maintaining CR in the pooled analysis was 53.0% (95% confidence interval [CI], 8.5, 85.0). Conclusions: For pts with R/R aggressive B-NHL who received blinatumomab, a durable response is possible. Longer-term follow up is needed to fully characterize the DOCR to blinatumomab. Clinical trial information: NCT01741792; NCT02910063. [Table: see text]
Improving classification accuracy of feedforward neural networks for\n spiking neuromorphic chips (2017)

Deep Neural Networks (DNN) achieve human level performance in many image\nanalytics tasks but DNNs are mostly deployed to GPU platforms that consume a\nconsiderable amount of power. New hardware platforms using lower precision\narithmetic achieve drastic reductions in power consumption. More recently,\nbrain-inspired spiking neuromorphic chips have achieved even lower power\nconsumption, on the order of milliwatts, while still offering real-time\nprocessing.\n However, for deploying DNNs to energy efficient neuromorphic chips the\nincompatibility between continuous neurons and synaptic weights of traditional\nDNNs, discrete spiking neurons and synapses of neuromorphic chips need to be\novercome. Previous work has achieved this by training a network to learn\ncontinuous probabilities, before it is deployed to a neuromorphic architecture,\nsuch as IBM TrueNorth Neurosynaptic System, by random sampling these\nprobabilities.\n The main contribution of this paper is a new learning algorithm that learns a\nTrueNorth configuration ready for deployment. We achieve this by training\ndirectly a binary hardware crossbar that accommodates the TrueNorth axon\nconfiguration constrains and we propose a different neuron model.\n Results of our approach trained on electroencephalogram (EEG) data show a\nsignificant improvement with previous work (76% vs 86% accuracy) while\nmaintaining state of the art performance on the MNIST handwritten data set.\n
Characterization of the BCR promoter in Philadelphia chromosome-positive and -negative cell lines. (1991)

The t(9;22) Philadelphia chromosome translocation fuses 5' regulatory and coding sequences of the BCR gene to the c-ABL proto-oncogene. This results in the formation of hybrid BCR-ABL mRNAs and proteins. The shift in ABL transcriptional control to the BCR promoter may play a role in cellular transformation mediated by this rearrangement. We have functionally localized the BCR promoter to a region 1 kb 5' of BCR exon 1 coding sequences by using a chloramphenicol acetyltransferase reporter gene assay. Nucleotide sequence analysis of this region revealed many consensus binding sequences for transcription factor SP1 as well as two potential CCAAT box binding factor sites and one putative helix-loop-helix transcription factor binding site. No TATA-like or "initiator" element sequences were found. Because of low steady-state levels of BCR mRNA and the high GC content (78%) of the promoter region, definitive mapping of transcription start sites required artificial amplification of BCR promoter-directed transcripts. Overexpression from the BCR promoter in a COS cell system was effective in demonstrating multiple transcription initiation sites. In order to assess the effects of chromosomal translocation on the transcriptional control of the BCR gene, we determined S1 nuclease protection patterns of poly(A)+ RNA from tumor cell lines. No differences were observed in the locations and levels of BCR transcription initiation sites between those lines that harbored the t(9;22) translocation and those that did not. This demonstrates that BCR promoter function remains intact in spite of genomic rearrangement. The BCR promoter is structurally similar to the ABL promoters. Together, this suggests that the structural fusion of BCR-ABL and not its transcriptional deregulation is primarily responsible for the transforming effect of the t(9;22) translocation.
Apogeu e Decadência do Império Português: o profetismo bandárrico (2008)

Resumo: A proposta incide sobre a observacao das Trovas do Bandarra e, inserindo-se na tematica do sebastianismo na cultura portuguesa, abarca tambem alguns aspectos relacionados com a interseccao entre cultura popular e cultura erudita. Goncalo Anes, o Bandarra, deveu a sua celebridade mais a interpretacao sebastianista das suas trovas do que ao seu estro poetico, assim, neste estudo tivemos em linha de conta a natureza multifacetada e aberta da sua obra, considerada por muitos historiadores como o documento fundamental da crenca sebastica. Neste trabalho intentamos articular diferentes niveis de analise, embora a investigacao sobre os problemas levantados pelos contextos de producao e recepcao nos tivessem interessado muito mais do que a analise da estrutura interna da obra, um auto pastoril muito singelo. No entanto, pensamos que uma maior atencao dada ao seu conteudo revelaria certamente aspectos muito interessantes para o estudo da cultura portuguesa no seculo XVI. O Estado Liberal na linha da tradicao romântica fez da cultura popular o seu estandarte para a defesa da identidade nacional e, nao por acaso, Fernando Pessoa viu em Bandarra o simbolo de Portugal. Palavras-chave: Profetismo, cultura popular, identidade nacional.
Multi-user Relaying with Full Frequency Reuse for Enhanced LTE-GBR Coverage (2011)

LTE-OFDM systems will be deployed on the next generation of cellular networks. The peak data rate capability has undergone a tremendous improvement. Yet, novel outdoor to indoor coverage solutions are needed, mainly because more users are expected to be indoors where the fading loss is high. Relaying has been considered as a promising solution. Here we provide a novel scheme for delivering guaranteed instantaneous bit rate to users via decode and forward (DF) relays, which exploit full frequency reuse indoors. We employ hierarchical OFDMA to support multiple relays and to allow multiple users to access each relay. We then suggest optimisation of channel access to base station considering that the relays are half duplex. A pertinent question then arises whether relaying is performance-effective. We find that significant coverage gain can be obtained from our solution, mainly from taking advantage of the frequency diversity and spatial diversity available at the DF relay. To obtain realistic numerical results, we use measured channels and a motivational case of 2 Mbps user bit rates.
Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: Results from the EPIC cohort (2020)

A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 791 cases and 1669 matched controls. Serum antibodies against C. trachomatis, Mycoplasma genitalium, herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) 16, 18 and 45 were assessed using multiplex fluorescent bead-based serology. Conditional logistic regression was used to estimate relative risks (RR) and 95% confidence intervals (CI) comparing women with positive vs. negative serology. A total of 40% of the study population was seropositive to at least one STI. Positive serology to C. trachomatis Pgp3 antibodies was not associated with EOC risk overall, but with higher risk of the mucinous histotype (RR = 2.30 [95% CI = 1.22-4.32]). Positive serology for chlamydia heat shock protein 60 (cHSP60-1) was associated with higher risk of EOC overall (1.36 [1.13-1.64]) and with the serous subtype (1.44 [1.12-1.85]). None of the other evaluated STIs were associated with EOC risk overall; however, HSV-2 was associated with higher risk of endometrioid EOC (2.35 [1.24-4.43]). The findings of our study suggest a potential role of C. trachomatis in the carcinogenesis of serous and mucinous EOC, while HSV-2 might promote the development of endometrioid disease.
Unsupervised Discovery of Actions in Instructional Videos (2021)

In this paper we address the problem of automatically discovering atomic actions in unsupervised manner from instructional videos. Instructional videos contain complex activities and are a rich source of information for intelligent agents, such as, autonomous robots or virtual assistants, which can, for example, automatically `read' the steps from an instructional video and execute them. However, videos are rarely annotated with atomic activities, their boundaries or duration. We present an unsupervised approach to learn atomic actions of structured human tasks from a variety of instructional videos. We propose a sequential stochastic autoregressive model for temporal segmentation of videos, which learns to represent and discover the sequential relationship between different atomic actions of the task, and which provides automatic and unsupervised self-labeling for videos. Our approach outperforms the state-of-the-art unsupervised methods with large margins. We will open source the code.
Flexible Pulse-Shape Picosecond Front-End for XFEL Photocathode Lasers (2019)

X-ray Free-Electron Lasers rely on low-emittance photo-injectors driven by UV laser pulses. For optimum performance temporally shaped laser pulses are desired. Here we present a laser front-end which delivers NIR ps-laser pulses of arbitrary pulse-envelope. © 2019 The Author(s)
Controlling cell migration and adhesion into a scaffold by external electric currents (2015)

Fabrication of more complex tissue-engineered structures, resembling the tissues and organs in vivo requires combining more than one cell type within the same construct. This can be achieved by designing and fabricating complex scaffolds with asymmetric properties but controlled arrangement of cells within the scaffold could also be realized by using electric current. External electric currents are able to modify cell adhesion, orientation and migration and this can be used for influencing cell location within a scaffold. In this paper we studied the effect of an electric current on cell migration and adhesion into a three-dimensional scaffold through a conductive mesh.
High spatial resolution 1H‐MRSI and segmented MRI of cortical gray matter and subcortical white matter in three regions of the human brain (1999)

High-resolution MR imaging and spectroscopic imaging were used to study differences in proton spectra between cortical gray matter and subcortical white matter in 23 normal volunteers using a 1.5 T scanner and surface coil receivers. A point-resolved spectroscopy (PRESS) volume with an 8 × 8 × 8 phase-encoding matrix was used to acquire over 1900 0.09–0.2 cc spectral voxels. The high-resolution (0.7 × 0.7 × 0.8 mm3 or 0.8 × 0.8 × 1 mm3) images were corrected for the surface coil reception profile and segmented into cerebrospinal fluid (CSF) and gray and white matter to correlate with the spectra. The data showed that N-acetyl aspartate (NAA) and creatine (Cr) were higher in the gray matter than in the white matter (NAAg/w = 1.4 ± 0.36, Crg/w = 1.4 ± 0.41). Choline was significantly lower in the gray matter of the occipital lobe than in the white matter (0.73 ± 0.19), but not significantly different in the other regions. NAA/Cho was found to be significantly higher in the occipital lobe than in the left frontal or vertex regions. Magn Reson Med 41:21-29, 1999. © 1999 Wiley-Liss, Inc.
Materials for nonlinear optics‐orientationally ordered polymer films (1989)

Abstract Emerging guided‐wave integrated optical technologies require suitable active devices and optical interconnects. Certain organic molecular materials possess the required optical nonlinearities for application in active devices. Glassy polymers, such as poly(methyl methacrylate), have been used to fabricate high optical quality passive structures. For application in integrated optics, requirements include high optical quality (low scattering and absorption losses), low dielectric constant, and suitable fabrication techniques. We describe the preparation and optical properties of a new material, class, poled polymer glasses, which combines the attractive properties of the optical nonlinearities of organic molecules and the optical quality of polymer glasses. These materials are formed by incorporating organic compounds possessing large optical nonlinearities into a host material lacking long‐range order. The orientational order is imparted to the composite system by applying a strong electric field at a temperature above the glass transition temperature, where molecular motion is enhanced, thereby aligning the optically nonlinear dopant molecules. By cooling the material through the phase transition with the field still applied, the orientational order is frozen in, and the composite material possesses second‐order nonlinear optical properties.
Remarkable catalysis of intersystem crossing of singlet (pentafluorophenyl)nitrene (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRemarkable catalysis of intersystem crossing of singlet (pentafluorophenyl)nitreneRussell Poe, Jennifer Grayzar, M. Jennifer T. Young, Elisa Leyva, Karlyn A. Schnapp, and Matthew S. PlatzCite this: J. Am. Chem. Soc. 1991, 113, 8, 3209–3211Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://doi.org/10.1021/ja00008a080RIGHTS & PERMISSIONSArticle Views287Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (356 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Protein engineering of chymosin and expression in Trichoderma reesei (1991)

Conference Article| August 01 1991 Protein engineering of chymosin and expression in Trichoderma reesei Jim E. Pitts; Jim E. Pitts 1Laboratory of Molecular Biology, Department of Crystallography, Birkbeck College, Malet Street, London WCIE 7HX, U.K. Search for other works by this author on: This Site PubMed Google Scholar Dominic Quinn; Dominic Quinn 1Laboratory of Molecular Biology, Department of Crystallography, Birkbeck College, Malet Street, London WCIE 7HX, U.K. Search for other works by this author on: This Site PubMed Google Scholar Jaana Uusitalo; Jaana Uusitalo *Biotechnical Laboratory, VTT, Espoo, Finland Search for other works by this author on: This Site PubMed Google Scholar Merja Penttilä Merja Penttilä *Biotechnical Laboratory, VTT, Espoo, Finland Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: April 12 1991 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1991 Biochemical Society1991 Biochem Soc Trans (1991) 19 (3): 663–666. https://doi.org/10.1042/bst0190663 Article history Received: April 12 1991 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Jim E. Pitts, Dominic Quinn, Jaana Uusitalo, Merja Penttilä; Protein engineering of chymosin and expression in Trichoderma reesei. Biochem Soc Trans 1 August 1991; 19 (3): 663–666. doi: https://doi.org/10.1042/bst0190663 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: cbh, cellobiohydrolase This content is only available as a PDF. © 1991 Biochemical Society1991 Article PDF first page preview Close Modal You do not currently have access to this content.
A 13Bit 5GS/S ADC with Time-Interleaved Chopping Calibration in 16NM FinFET (2018)

A 13bit 5GS/s time-interleaved ADC is described which uses a chopping technique to reduce the effect of interleaved flicker noise spectral artefacts and to increase the ADC immunity to input signal characteristics. Enhanced offset and time-skew calibration algorithms are developed to maximize the performance in the presence of non-ideal sampling switches. At 5GS/s, the ADC dissipates 641mW while achieving a 62dB and 57dB of SFDR and SNDR respectively while maintaining a SFDR excluding HD2 and HD3 better than 70dBc across the first Nyquist band for input amplitudes down to -20dBFS.
Strong and Tough Chitin Film from α-Chitin Nanofibers Prepared by High Pressure Homogenization and Chitosan Addition (2018)

Chitin nanofibers are an interesting biological nanomaterial for advanced applications, for example, in medicine, electronics, packaging and water purification. The challenge is to separate chitin nanofibers from protein in the exoskeleton structure of arthropods and avoid nanofibril aggregation to realize the mechanical potential of chitin. In this work, we developed a new method for the preparation of chitin nanofibers from lobster shell exoskeleton using 10 wt % chitosan as a sacrificial polymer. The addition of chitosan in the raw chitin colloidal suspension during high pressure homogenization process at pH 3 significantly reduced the agglomeration of chitin nanofibers as revealed by dynamic light scattering and transmission electron microscopy. Chitin film prepared from the chitin nanofiber suspension by vacuum filtration exhibited a true nanofibrils network structure without fibril aggregations as characterized by scanning electron microscopy. The presence of chitosan not only improves the colloidal stability of chitin nanofibers suspension but also facilitates the formation of chitin nanofiber network structure in the film as indicated by wide-angle X-ray diffraction analysis. The chitin nanofiber film with 4 ± 1 wt % residual chitosan showed high tensile strength (187.2 ± 5.6 MPa) and high work of fracture (12.1 ± 0.4 MJ/m3), much higher than those chitin and chitosan films reported previously in the literature.
In Vivo Endoscopic Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS) (2015)

Abstract Gastrointestinal cancers are a leading cause of mortality, accounting for 23 % of cancer‐related deaths worldwide. In order to improve outcomes from these cancers, novel tissue characterization methods are needed to facilitate accurate diagnosis. Rapid evaporative ionization mass spectrometry (REIMS) is a technique developed for the in vivo classification of human tissue through mass spectrometric analysis of aerosols released during electrosurgical dissection. This ionization technique was further developed by utilizing surface induced dissociation and was integrated with an endoscopic polypectomy snare to allow in vivo analysis of the gastrointestinal tract. We tested the classification performance of this novel endoscopic REIMS method in vivo. It was shown to be capable of differentiating between healthy layers of the intestinal wall, cancer, and adenomatous polyps based on the REIMS fingerprint of each tissue type in vivo.
Fundamental impact-welding parameters—an experimental investigation using a 76-mm powder cannon (1980)

A specially designed 76-mm cannon was used to drive small metal plates (copper, 3.175 mm thick) against metal target plates (steel, 6.250 mm thick) in order to study the fundamental parameters involved in the high-velocity impact-welding process. This method of study allowed experimental examination of the influence of each variable separately, in the classical mode. The results of these experiments were analyzed to define the required impact conditions for welding. A line of optimum weldability was identified and shown to be characterized by invariance in the metallic jet velocity. The analysis was also used to identity conditions applying to the transition zone between laminar and wavy interfaced welds.
Complementary metal oxide semiconductor compatible fabrication and characterization of parylene-C covered nanofluidic channels with integrated nanoelectrodes (2009)

Nanochannels offer a way to align and analyze long biopolymer molecules such as DNA with high precision at potentially single basepair resolution, especially if a means to detect biomolecules in nanochannels electronically can be developed. Integration of nanochannels with electronics will require the development of nanochannel fabrication procedures that will not damage sensitive electronics previously constructed on the device. We present here a near-room-temperature fabrication technology involving parylene-C conformal deposition that is compatible with complementary metal oxide semiconductor electronic devices and present an analysis of the initial impedance measurements of conformally parylene-C coated nanochannels with integrated gold nanoelectrodes.