gebhart/patrepeval huggingface dataset:
Learning Model-Based Sparsity via Projected Gradient Descent (2016)

Several convex formulation methods have been proposed previously for statistical estimation with structured sparsity as the prior. These methods often require a carefully tuned regularization parameter, often a cumbersome or heuristic exercise. Furthermore, the estimate that these methods produce might not belong to the desired sparsity model, albeit accurately approximating the true parameter. Therefore, greedy-type algorithms could often be more desirable in estimating structured-sparse parameters. So far, these greedy methods have mostly focused on linear statistical models. In this paper, we study the projected gradient descent with a non-convex structured-sparse parameter model as the constraint set. Should the cost function have a stable model-restricted Hessian, the algorithm produces an approximation for the desired minimizer. As an example, we elaborate on application of the main results to estimation in generalized linear models.
Biochemical analysis of serum of rats treated with multiple doses of Phe-Ala-PQ or PQ (mean ±CI 95). (2015)

a&lt;p&gt;: p&lt;0.05 compared with control group;&lt;/p&gt;b&lt;p&gt;: p&lt;0.05 compared with PQ group.&lt;/p&gt;
Modeling and design of an EMI-immune source-buffered Miller OpAmp in 0.18 μm CMOS technology (2017)

This paper presents the modeling and design of a source-buffered Miller operational amplifier structure that is highly immune to electromagnetic interference (EMI). The source-buffered Miller operational amplifier is designed and fabricated in the 0.18 μm mixed-mode CMOS process and modeled mathematically including the body effect and channel length modulation. Measurement results show that the maximum EMI-induced input offset voltage for the source-buffered Miller operational amplifier is 22 mV at 1 GHz, when a 900 mVpp EMI signal is applied at its input. In contrast, the standard Miller operational amplifier generates an input offset voltage of 215 mV under the same operating conditions.
Building Anvi'o profiles + Interactive Viewer v1 (2017)

Protocol details how to create and merge Anvi'o profiles to view them using anvi-interactive.
Raman lasing and soliton modelocking in lithium-niobate microresonators (2019)

The recent advancement in lithium niobate on insulator (LNOI) technology is revolutionizing the optoelectronic industry as devices of higher performance, lower power consumption, and smaller footprint can be realized due to the high optical confinement in the structures. The LNOI platform offers both large \c{hi}(2) and \c{hi}(3) nonlinearities along with the power of dispersion engineering, enabling brand new nonlinear photonic devices and applications towards the next generation of integrated photonic circuits. However, the Raman scattering, one of the most important nonlinear phenomena, have not been extensively studied, neither was its influences in dispersion-engineered LNOI nano-devices. In this work, we characterize the Raman radiation spectra in a monolithic lithium niobate (LN) microresonator via selective excitation of Raman-active phonon modes. Remarkably, the dominant mode for Raman oscillation is observed in the backward direction for a continuous-wave pump threshold power of 20 mW with a reportedly highest differential quantum efficiency of 46 %. In addition, we explore the effects of Raman scattering on Kerr optical frequency combs generation. We achieve, for the first time, soliton modelocking on a X-cut LNOI chip through sufficient suppression of the Raman effect via cavity geometry control. Our analysis of the Raman effect provides guidance for the development of future chip-based photonic devices on the LNOI platform.
Bidirectional Telemetry Controller for Neuroprosthetic Devices (2009)

We present versatile multifunctional programmable controller with bidirectional data telemetry, implemented using existing commercial microchips and standard Bluetooth protocol, which adds convenience, reliability, and ease-of-use to neuroprosthetic devices. Controller, weighing 190 g, is placed on animal's back and provides bidirectional sustained telemetry rate of 500 kb/s , allowing real-time control of stimulation parameters and viewing of acquired data. In continuously-active state, controller consumes approximately 420 mW and operates without recharge for 8 h . It features independent 16-channel current-controlled stimulation, allowing current steering; customizable stimulus current waveforms; recording of stimulus voltage waveforms and evoked neuronal responses with stimulus artifact blanking circuitry. Flexibility, scalability, cost-efficiency, and a user-friendly computer interface of this device allow use in animal testing for variety of neuroprosthetic applications. Initial testing of the controller has been done in a feline model of brainstem auditory prosthesis. In this model, the electrical stimulation is applied to the array of microelectrodes implanted in the ventral cochlear nucleus, while the evoked neuronal activity was recorded with the electrode implanted in the contralateral inferior colliculus. Stimulus voltage waveforms to monitor the access impedance of the electrodes were acquired at the rate of 312 kilosamples/s. Evoked neuronal activity in the inferior colliculus was recorded after the blanking (transient silencing) of the recording amplifier during the stimulus pulse, allowing the detection of neuronal responses within 100 mus after the end of the stimulus pulse applied in the cochlear nucleus.
Characterization of Amplification Properties of the Superconducting-Ferromagnetic Transistor (2020)

We report on the measurement results of the superconducting-ferromagnetic transistors (SFTs). The devices were made at Northwestern University and Hypres (SeeQC), Inc. (Nevirkovets et al., 2014; 2015). SFT is a multiterminal device with the SIS'FIFS (or SFIFS'IS) structure (where S, I, and F denote a superconductor, an insulator, and a ferromagnetic material, respectively) exploiting intense quasiparticle injection in order to modify the nonlinear I-V curve of a superconducting tunnel junction. SFT is capable of providing voltage, current, and power amplification while having good input/output isolation. We characterized the devices using different measurement techniques. We measured S parameters of the single- and double-acceptor devices at frequencies up to 5 MHz. Importantly, we confirmed that the isolation between the input and output of the device is quite good. However, the techniques typically employed to characterize semiconductor devices do not allow for revealing the full potential of our low-resistive SFT devices, especially those having two acceptors. In the latter case, we also tested the devices using the battery-powered current sources with floating grounds. Analyzing double-acceptor I-V curves recorded at different levels of injection currents, for an optimal load, we deduced a small-signal voltage gain of 33 and a power gain of 2.4. We suggest that further improvement of the SFT device parameters is possible in optimized devices, so that the device potentially may serve as a preamplifier for readout of output signals of cryogenic detectors and be useful as an element of other superconductor-based circuits. In addition, we used scanning transmission electron microscopy to identify some problems in the fabrication of the devices without any planarization.
Leucyl-leucine methyl ester-treated haploidentical donor lymphocyte infusions can mediate graft-versus-leukemia activity with minimal graft-versus-host disease risk (2002)

L-leucyl-L-leucine methyl ester (LLME) prevents GVHD in several animal models by depleting dipeptidyl peptidase I (DPPI)-expressing cytotoxic cellular subsets. However, clinical application has been hampered by difficulties in stem cell engraftment following treatment of donor bone marrow inocula with LLME at the concentrations necessary to purge DPPI-expressing T-cells. Noting that T-cells can mediate graft-versus-leukemia (GVL) responses via both perforin (usually co-expressed in cytotoxic granules with DPPI) and Fas ligand pathways in a murine model, we hypothesized that LLME might be useful for treatment of delayed DLIs for potential GVL activity with a decreased risk of GVHD induction. In regard to the clinical setting, the ex vivo use of LLME for this purpose would circumvent any toxicity issues for donor stem cells, because by that time patients would have already achieved successful engraftment. For our preclinical studies, we used the haploidentical C57BL/6 (B6) (H2b) --> ((B6 x DBA/2)F1 (H(2b/d)) murine model with lethally irradiated hosts that had received transplants of T-cell-depleted bone marrow cells and were challenged with the MMD2-8 myeloid leukemia line (H2d) of DBA/2 origin. A DLI of LLME-treated donor splenocytes, from B6 mice presensitized to recipient alloantigens, was administered in varying doses 14 days post-marrow transplantation, and the potential for both GVHD and GVL activity was assessed. All mice that received any dose of LLME-treated DLI survived indefinitely, without evidence of cachexia nor B-cell hypoplasia, in contrast to the severe and lethal GVHD induced by mock-treated DLI. Histological analysis largely correlated with the symptomatic findings and revealed no GVHD-like lesions in the spleens of LLME-treated DLI recipients, although some mice displayed various degrees of hepatic mononuclear infiltration. Most notably, mice given LLME-treated DLI also experienced DLI dose-dependent increases in survival against the challenge with the MMD2-8 leukemia. LLME-treated splenocytes remained immunocompetent, as these cells could proliferate in response to mitogens and to restimulation with ovalbumin when used as a recall antigen. In conclusion, LLME-treated DLI possesses immune potential and, in particular, GVL activity without inducing clinically evident GVHD.
Innovative Airspeed Sensing Based on a Micromachined Sensor (2023)

The adaptability of QVAR to integrate with inertial sensors makes it useful as an auxiliary sensor for navigation. It can assist in navigation under challenging GPS conditions by utilizing Dead Reckoning based on airspeed estimates and inertial data. Additionally, QVAR can enhance the accuracy of air data sensors by utilizing cross-sensor queuing with air data sensors. The innovative technology of QVAR offers significant advantages for navigation compared to traditional Pitot tubes. It eliminates the need for airspeed estimation inlets and serves as a low-cost digital sensor. Moreover, QVAR can be easily tested on remotely piloted aircraft systems. Its minimal requirements in terms of mass, size, power consumption, and complexity make it a highly promising solution for airspeed sensing, especially on platforms with limited available resources like small unmanned aircraft. The following paper presents the development of a prototypal sensor, namely Qvar, produced by STMicroelectronics and based on MEMS technology. A digital output has been derived, and several laboratory tests have been conducted to find a correlation between this output and the speed of airflow, with the aim to exploit the developed sensor for estimating the airspeed of a drone.
New technologies in catalysis using base metals (2006)

Abstract Formation of C-C, C-N, and C-H bonds using three heterogeneous catalysts in the form of nickel-in-charcoal (Ni/C), nickel-on-graphite (Ni/C g ), and copper-in-charcoal (Cu/C) are described.
Pyrolysis modeling, sensitivity analysis, and optimization techniques for combustible materials: A review (2019)

Over the past years, pyrolysis models have moved from thermal models to comprehensive models with great flexibility including multi-step decomposition reactions. However, the downside is the need for a complete set of input data such as the material properties and the parameters related to the decomposition kinetics. Some of the parameters are not directly measurable or are difficult to determine and they carry a certain degree of uncertainty at high temperatures especially for materials that can melt, shrink, or swell. One can obtain input parameters by searching through the literature; however, certain materials may have the same nomenclature but the material properties may vary depending on the manufacturer, thereby inducing uncertainties in the model. Modelers have resorted to the use of optimization techniques such as gradient-based and direct search methods to estimate input parameters from experimental bench-scale data. As an integral part of the model, a sensitivity study allows to identify the role of each input parameter on the outputs. This work presents an overview of pyrolysis modeling, sensitivity analysis, and optimization techniques used to predict the fire behavior of combustible solids when exposed to an external heat flux.
Hardware Support For Large Atomic Units in Dynamically Scheduled Machines (1988)

Microarchitectures that implement conventional instruction set architectures are usually limited in that they are only able to execute a small number of microoperations concurrently. This limitation is due in part to the fact that the units of work that the hardware treats as indivisible are small. While this limitation is not important for microarchitectures with a low level of functionality, it can be significant if the goal is to build hardware that can support a large number of microoperations executing concurrently. In this paper we address the tradeoffs associated with the sizes of the various units of work that a processor considers indivisible, or atomic. We argue that by allowing larger units of work to be atomic, restrictions on concurrent operation are reduced and performance is increased. We outline the implementation of a front end for a dynamically scheduled processor with hardware support for large atomic units. We discuss tradeoffs in the design and show that with a modest investment in hardware, the run-time advantages of large atomic units can be realized without the need to alter the instruction set architecture.
Study of coupled QED-cavities using the self-consistent Mori projector method (2014)

We study the non-equilibrium properties of nonlinear QED-cavities coupled via photon tunneling in the presence of dissipation and coherent pumping. To illustrate the interplay between photon leakage, Rabi oscillations, and coherent photon hopping, we examine the dynamical evolution and the stationary states of finite cavity arrays in the highly nonlinear regime. Finally, we employ a cluster version of the self-consistent Mori projector method and show both its accuracy and efficiency for the determination of local quantities in the highly complex many-body situation at hand.
TABLE 1 from A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors (2023)

&lt;p&gt;Pharmacokinetic parameters of 3A and 3B in the mouse&lt;a href="#tb1fn1" target="_blank"&gt;&lt;sup&gt;a&lt;/sup&gt;&lt;/a&gt;&lt;/p&gt;
Erhöhung der Akzeptanz von Produktionssimulationen (2021)

Abstract Der Einsatz von Simulation birgt Potenzial für die Auslegung und Bewertung technischer Konzepte und Steuerungsmechanismen von Produktionslinien. Industrielle Anforderung für den Einsatz von Simulation stellen Benutzerschnittstellen für eine vereinfachte Nutzung und Auswertung von Simulationsmodellen dar. In diesem Beitrag werden die Ergebnisse des Werkzeugmaschinenlabors der RWTH Aachen und der Beiersdorf AG zur gemeinsamen Entwicklung einer anwenderfreundlichen Benutzerschnittstelle für den industriellen Einsatz ereignisorientierter Simulation vorgestellt.**
Condensed rotational separation of CO2 from natural gas (2009)

Abstract This article describes measurements of methane purification by condensed rotational separation. First, the separation concept is introduced. Then the test‐setup and measurements are described. The thermodynamic performance of the system is compared with thermodynamic predictions and is found to be in good agreement. The separation performance of the centrifugal separator is addressed. © 2009 American Institute of Chemical Engineers AIChE J, 2010
Separation of Microscale Chiral Objects by Shear Flow (2009)

We show that plane parabolic flow in a microfluidic channel causes nonmotile, helically shaped bacteria to drift perpendicular to the shear plane. Net drift results from the preferential alignment of helices with streamlines, with a direction that depends on the chirality of the helix and the sign of the shear rate. The drift is in good agreement with a model based on resistive force theory, and separation is efficient (>80%) and fast (<2 s). We estimate the effect of Brownian rotational diffusion on chiral separation and show how this method can be extended to separate chiral molecules.
Doublecortin-Like Kinase 1 Is Elevated Serologically in Pancreatic Ductal Adenocarcinoma and Widely Expressed on Circulating Tumor Cells (2015)

Doublecortin-like kinase 1 (DCLK1) is a putative pancreatic stem cell marker and is upregulated in pancreatic cancer, colorectal cancer, and many other solid tumors. It marks tumor stem cells in mouse models of intestinal neoplasia. Here we sought to determine whether DCLK1 protein can be detected in the bloodstream and if its levels in archived serum samples could be quantitatively assessed in pancreatic cancer patients. DCLK1 specific ELISA, western blotting, and immunohistochemical analyses were used to determine expression levels in the serum and staining intensity in archived tumor tissues of pancreatic ductal adenocarcinoma (PDAC) patients and in pancreatic cancer mouse models. DCLK1 levels in the serum were elevated in early stages of PDAC (stages I and II) compared to healthy volunteers (normal controls). No differences were observed between stages III/IV and normal controls. In resected surgical tissues, DCLK1 expression intensity in the stromal cells was significantly higher than that observed in tumor epithelial cells. Circulating tumor cells were isolated from KPCY mice and approximately 52% of these cells were positive for Dclk1 staining. Dclk1 levels in the serum of KPC mice were also elevated. We have previously demonstrated that DCLK1 plays a potential role in regulating epithelial mesenchymal transition (EMT). Given the increasingly recognized role of EMT derived stem cells in cancer progression and metastasis, we hypothesize that DCLK1 may contribute to the metastatic process. Taken together, our results suggest that DCLK1 serum levels and DCLK1 positive circulating tumor cells should be further assessed for their potential diagnostic and prognostic significance.
Supplementary Video 4J from Selective Targeting and Potent Control of Tumor Growth Using an EphA2/CD3-Bispecific Single-Chain Antibody Construct (2023)

Supplementary Video 4J from Selective Targeting and Potent Control of Tumor Growth Using an EphA2/CD3-Bispecific Single-Chain Antibody Construct
Modeling the Effect of Low Carbon Conductivity of the Cathode Catalyst Layer on PEM Fuel Cell Performance (2010)

Carbon corrosion is a major degradation mechanism in cathode catalyst layers (CCL) of PEM fuel cells. Carbon corrosion causes carbon particles to decrease in size and the ionomer to carbon ratio to increase. One of the consequences of these changes is the reduced electronic conductivity of the carbon phase in CCL. In the present study, the effect of reduced carbon conductivity on the cell performance was investigated through modeling of two experimental case studies of a fresh and a severely degraded CCL. The critical carbon conductivity of CCL, below which the electronic potential loss in a degraded CCL becomes an important contributing loss, is defined. The inter-relations between low carbon conductivity, electronic ohmic loss, and EPSA loss (through Pt/C particles detachment mechanism) are also discussed.
Hydrodeoxygenation of Vicinal OH Groups over Heterogeneous Rhenium Catalyst Promoted by Palladium and Ceria Support (2014)

Abstract Heterogeneous ReO x –Pd/CeO 2 catalyst showed excellent performance for simultaneous hydrodeoxygenation of vicinal OH groups. High yield (&gt;99 %), turnover frequency (300 h −1 ), and turnover number (10 000) are achieved in the reaction of 1,4‐anhydroerythritol to tetrahydrofuran. This catalyst can be applied to sugar alcohols, and mono‐alcohols and diols are obtained in high yields (≥85 %) from substrates with even and odd numbers of OH groups, respectively. The high catalytic performance of ReO x –Pd/CeO 2 can be assigned to rhenium species with +4 or +5 valence state, and the formation of this species is promoted by H 2 /Pd and the ceria support.
Functional Calcium Imaging: Maximally selective single cell target for circuit control in epilepsy (2021)

This dataset contains all functional calcium imaging datasets of larval zebrafish acute seizure models (whole-brain, cellular-resolution, N=3); dentate gyrus granule cells from control dentate gyrus (N=3); dentate gyrus granule cells from dentate gyrus of mice with chronic temporal lobe epilepsy (N=3). Additionally, the zebrafish datasets contain the physical location of each neuron after registration to a zebrafish atlas, as well as the physical brain region the neuron inhabits.
Re: Prevention of Maternal Aging-Associated Oocyte Aneuploidy and Meiotic Spindle Defects in Mice by Dietary and Genetic Strategies (2012)

No AccessJournal of UrologyUrological Survey1 May 2012Re: Prevention of Maternal Aging-Associated Oocyte Aneuploidy and Meiotic Spindle Defects in Mice by Dietary and Genetic Strategies Anthony AtalaM.D. Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.01.042AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Prevention of Maternal Aging-Associated Oocyte Aneuploidy and Meiotic Spindle Defects in Mice by Dietary and Genetic Strategies." The Journal of Urology, 187(5), pp. 1925–1926 © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187 Issue 5 May 2012 Page: 1925-1926 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.Metrics Author Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Changing LIBER (2006)

LIBER, the Ligue des Bibliothèques Européennes de Recherche, has as its mission the representation and promotion of the interests of research libraries in Europe, the improvement of access to collections in European research libraries, and the provision of more efficient information services in Europe.
Reduction of Titanium Dioxide to Metallic Titanium Conducted under the Autogenic Pressure of the Reactants (2009)

We report on a reaction to convert titanium dioxide to titanium. The reduction reaction was done under the autogenic pressure of the reactants at 750 degrees C for 5 h. The MgO, a by-product, was removed by acids to obtain pure metallic titanium.
Molecular Association of 2,3-Dihydro-2-alkyl-3-hydroxybenzisothiazole 1,1-Dioxides:  Formation of Novel Bicyclic Dimers Containing 12/14-Membered Rings (1998)

2,3-Dihydro-3-hydroxybenzisothiazole 1,1-dioxides constitute a self-complementary hydrogen-bond donor−acceptor system. 2,3-Dihydro-2-isopropyl-3-hydroxybenzisothiazole 1,1-dioxide exhibits interesting concentration and temperature-dependent NMR spectra due to association in solution. The intermolecular association of these molecules through S−O···H−O interactions resulting in the formation of novel hydrogen-bonded dimers containing 12/14-membered bicyclic bridge is revealed by X-ray crystallography. X-ray crystallographic studies also confirm the existence of N-alkyl-2-formylbenzenesulfonamides exclusively as 2,3-dihydro-2-alkyl-3-hydroxybenzisothiazole 1,1-dioxides in the solid state.