gebhart/patrepeval huggingface dataset:
Longitudinal Penalized Functional Regression for Cognitive Outcomes on Neuronal Tract Measurements (2012)

We describe and analyze a longitudinal diffusion tensor imaging (DTI) study relating changes in the microstructure of intracranial white matter tracts to cognitive disability in multiple sclerosis patients. In this application the scalar outcome and the functional exposure are measured longitudinally. This data structure is new and raises challenges that cannot be addressed with current methods and software. To analyze the data, we introduce a penalized functional regression model and inferential tools designed specifically for these emerging types of data. Our proposed model extends the Generalized Linear Mixed Model by adding functional predictors; this method is computationally feasible and is applicable when the functional predictors are measured densely, sparsely or with error. An online appendix compares two implementations, one likelihood-based and the other Bayesian, and provides the software used in simulations; the likelihood-based implementation is included as the lpfr() function in the R package refund available on CRAN.
On chip post-processed microbattery powered with RF and thermal energy through a power management circuit (2007)

The proposed microsystem architecture comprises two power sources, and a microbattery used as a storage unit ; a complete integrated circuit transforms and manages the harvested energy and interfaces the microbattery. The first source is a RF power receiver combined with a classical RF converter. The second micropower source is a 1V miniature thermogenerator based on sintered bismuth telluride thermoelements, combined with a micropower DC/DC up converter. The converter architecture includes an innovative power switch control designed for better power efficiency, and improved supply noise performance. The microbattery is a lithium, solid-state, battery post-processed on the integrated circuit. A discharge monitor with 5nW power consumption, along with a 78% efficiency charge unit interfaces the battery. These harvesting and power storage devices are foreseen as a way to provide power on a chip, allowing either permanent active security for smart card applications or sensors supply for monitoring applications for example.
Landmark Optimization Using Local Curvature for Point-Based Nonlinear Rodent Brain Image Registration (2011)

Purpose. To develop a technique to automate landmark selection for point-based interpolating transformations for nonlinear medical image registration. Materials and Methods. Interpolating transformations were calculated from homologous point landmarks on the source (image to be transformed) and target (reference image). Point landmarks are placed at regular intervals on contours of anatomical features, and their positions are optimized along the contour surface by a function composed of curvature similarity and displacements of the homologous landmarks. The method was evaluated in two cases (n = 5 each). In one, MRI was registered to histological sections; in the second, geometric distortions in EPI MRI were corrected. Normalized mutual information and target registration error were calculated to compare the registration accuracy of the automatically and manually generated landmarks. Results. Statistical analyses demonstrated significant improvement (P < 0.05) in registration accuracy by landmark optimization in most data sets and trends towards improvement (P < 0.1) in others as compared to manual landmark selection.
New Steroidal Alkaloids from Fritillaria imperialis and Their Cholinesterase Inhibiting Activities. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Growth rate dependence of nitrogen incorporation in reactively sputtered FeXN films for recording head poles (2000)

In this paper we show that the efficiency of nitrogen incorporation in reactively sputtered FeAlN and FeN films is strongly dependent on the growth rate of the films. Efficiency is defined as the amount of nitrogen incorporated for a given ratio of arriving iron atoms to arriving nitrogen atoms. These findings are in contrast to previous work, which has suggested the amount of nitrogen incorporated in the films should be determined by this arrival flux ratio alone, and independent of growth rate. This difference may be due to the larger range of deposition rates explored in this work. A simple and phenomenological kinetic model of the deposition process is used to rationalize the observed behavior. This behavior has important consequences for scaling the deposition of FeXN up to commercial deposition rates while maintaining soft magnetic properties. This is because the amount of nitrogen incorporated has a strong effect on the soft properties of these pole materials.
Methanol Extract of Polyopes lancifolius Suppresses Tumor Necrosis Factor-α-Induced <em>Matrix</em> Metalloproteinase-9 Expression in T24 Bladder Carcinoma Cells (2012)

Purpose: To investigate the effects of the methanol extract of Polyopes lancifolius (MEPL) on the expression of matrix metalloproteinase-9 (MMP-9) and invasion in T24 human bladder carcinoma cells.Methods: Reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analyses were performed to assess the expression of MMP-9 and its regulatory proteins. MMP-9 activity was evaluated using zymography while matrigel infiltration was performed to assess T24 bladder carcinoma invasion. Electrophoretic mobility assay was used to investigate the nuclear factor-&#954;B (NF-&#954;B) activity.Results: The expression and activity of MMP-9 were significantly increased in response to TNF-&#945;, but MEPL suppressed TNF-&#945;-induced MMP-9 expression and activity. MEPL also inhibited TNF-&#945;-induced MMP-9 expression at the transcriptional level by blocking the activation of the NF-&#954;B signaling pathway. Furthermore, the extract suppressed TNF-&#945;-induced phosphorylation of I&#954;B&#945; and consequently sustained cytosolic p65 and p50 expression. Matrigel invasion assay showed that MEPL significantly reduced TNF-&#945;-induced invasion of T24 bladder carcinoma cells.Conclusion: Collectively, these data indicate that MEPL regulates TNF-&#945;-induced MMP-9 expression by suppressing NF-&#954;B activity.
3‐Cyanoindole‐Based Inhibitors of Inosine Monophosphate Dehydrogenase: Synthesis and Initial Structure—Activity Relationships. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Dynamic Cache Reconfiguration Strategies for a Cluster-Based Streaming Proxy (2006)

The high bandwidth and the relatively long-lived characteristics of digital video are key limiting factors in the wide-spread usage of streaming content over the Internet. The problem is further complicated by the fact that video popularity changes over time. In this paper, we study caching issues for a cluster-based streaming proxy in the face of changing video popularity. We show that the cache placement problem for a given video popularity is NP-complete, and propose the dynamic first fit (DFF) algorithm that give the results close to the optimal cache placement. We then propose minimum weight perfect matching (MWPM) and swapping-based techniques that can dynamically reconfigure the cache placement to adapt to changing video popularity with minimum copying overhead. Our simulation results show that MWPM reconfiguration can reduce the copying overhead by a factor of more than two, and that swapping-based reconfiguration can further reduce the copying overhead compared to MWPM, and allow for the tradeoffs between the reconfiguration copying overhead and the proxy bandwidth utilization.
ChemInform Abstract: Unexpected Fluorous Solvent Effect on Oxidation of 1‐Thioglycosides. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Specific recognition of an FGFR2 fusion by tumor infiltrating lymphocytes from a patient with metastatic cholangiocarcinoma (2023)

This finding suggests that <i>FGFR2</i> fusion-reactive TILs can be isolated from some patients with metastatic ICC, and thus provides a rationale for future exploration of T cell-based therapy targeting <i>FGFR2</i> fusions in patients with cancer. Furthermore, it augments the rationale for extending such efforts to other types of solid tumors hallmarked by oncogenic gene fusions.
Optoelectronic device with a support member (2023)

Optoelectronic devices with a support member and methods of manufacturing or assembling the same are provided. An example of an optoelectronic device according to the present disclosure includes a substrate and an optical component and an electronic component disposed thereon or therein. The optoelectronic device further includes a ferrule coupled to the optical fiber and an optical socket receiving the ferrule therein. The optoelectronic device includes a support member disposed between the substrate and the optical socket such that the optical socket is spaced from the substrate by the support member.
Development of a New 300kv Ultra-High-Resolution/High Performance Analytical TEM (H-9000) (1985)

Higher voltage is advantageous for better imaging resolution, better EELS performance and easier microscopy. Generally it results in a large scaled instrument with many associated problems. In the analytical area, there is a possibility of optimum voltage when a total performance balance is taken in consideration. We have developed a 300 KV TEM for both ultra high resolution and high performance analytical applications in view of these parameters. We have suceeded in making the instrument as compact as possible in order that it may improve the cost/performance ratio. We have taken full advantage of our ultra high voltage microscope experiences. Fig. 1 is a general view of the instrument. It is only 2.68m high and the same as conventional 200KV instruments. It consists of a 3-stage illumination and a 5-stage imaging lens system. This design allows the orientation matching for the diffraction pattern and TEM image throughout the entire magnification range.
A 10 MHz mixed-signal CPM controlled DC-DC converter IC with novel gate swing circuit and instantaneous efficiency optimization (2011)

This paper introduces a mixed-signal peak current-programmed mode controlled 10 MHz dc-dc converter integrated circuit (IC) for low-power applications. The IC combines segmented power transistors, gate drivers and the main functional blocks of a multi-mode controller. Based on the information about the peak transistor current, obtained from the voltage loop, the controller instantaneously changes the number of segments, gate drive voltage, or switches to pulse-frequency modulation, such that for each operating point efficiency is optimized. To obtain reliable operation at such a high switching frequency and achieve efficiency optimization novel architecture of gate swing circuit is combined with modifications of known designs of other functional blocks. Experimental verification of a 0.6 W buck converter IC, fabricated in a 0.13 μm process, demonstrate the peak efficiency of an 83%, near time-optimal dynamic response, and up to a 20% efficiency improvement due to the action of the efficiency optimization controller.
Interleukin-32 in chronic inflammatory conditions is associated with a higher risk of cardiovascular diseases (2017)

Contains fulltext : 177608.pdf (Publisher’s version ) (Open Access)
ChemInform Abstract: Kinetically Controlled E‐Selective Catalytic Olefin Metathesis. (2016)

Abstract The kinetically E‐selective cross‐metathesis reactions is designed to generate thermodynamically disfavored alkenyl chlorides and fluorides in high yield and with exceptional stereoselectivity.
Performance of the high brightness linac for the Advanced Free Electron Laser Initiative at Los Alamos (1993)

The AFEL accelerator has produced beams of greater than 2 {times} 10{sup 12} A/m{sup 2} at 1 nC (brightness = 2*I/{var_epsilon}{sup 2}, with I greater than 100 A and {var_epsilon} of than 2 {pi} mm-mrad normalized ms emittance). The 1300 MHz standing-wave accelerator uses on-axis coupling cells. The electron source is a photoinjector with a CsK{sub 2}Sb photocathode. The photoinjector is an integral part of a single 11-cell accelerator structure. The accelerator operates between 12 and 18 MeV. The beam emittance growth in the accelerator is minimized by using a photoinjector, a focusing solenoid to correct the emittance growth due to space charge, and a special design of the coupling slots between accelerator cavities to minimize quadrupole effects. This paper describes the experimental results and compares those results with PARMELA simulation. The simulation code PARMELA was modified for this effort. This modified version uses SUPERFISH files for the accelerator cavity fields, MAFIA files for the fields due to the coupling slots in the accelerator cells, and POISSON files for the solenoid field in the gun region.
Multiple Clonal Abnormalities in the Bronchial Epithelium of Patients With Lung Cancer (1999)

Our findings indicate that multiple small clonal or subclonal patches containing molecular abnormalities are present in normal or slightly abnormal bronchial epithelium of patients with lung cancer.
56.1: High‐Frame‐Rate, High‐Contrast Grating Light Valve Laser Projection Display (2008)

Abstract We report a high frame rate (240Hz), high contrast (30,000:1), wide color gamut GxL (G‐by‐L) laser projector. Proposed application areas for GxL are also discussed.
Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis (2021)

CRD42020152050.
Természetes vegyületek és szintetikus származékaik NMR szerkezetfelderítése = Structure elucidation of natural compounds and their synthetic derivates (2008)

Magyar és nemzetközi kooperációban végzett kutatómunkánk 49 publikációt eredményezett, folyóiratokban megjelent közlemények száma 23. Munkánk főrészét a népi gyógyászatban is használt növényekből izolált, ismeretlen szerkezetű vegyületek szerkezetfelderítése tette ki, amelyhez alapvetően a legmodernebb, igen kis anyagmennyiségek vizsgálatát is megengedő protondetektált NMR módszereket alkalmaztuk, továbbá szemiempírikus számításokat is végeztünk. Az ekdiszteroidok témakörében közel 100 izolált terméket vizsgáltunk, melyek közül kb. 15 új szerkezetű vegyületet találtunk. Egyiptomi kutatókkal végzett munkáink kapcsán flavanol-, iridoid-, lignán-, triterpén-glikozidok és szeszkviterpének szerkezetfelderítését elvégeztük el. A természetes vegyületek szintetikus származékai témakörben indol-, indolizidino-, az izokinolin- és a piridoindol-vázas alkaloidszármazékok szerkezetét határoztuk meg. A 3-aril-1-(3-kumarinil)propen-1-on és a 2-amino-tiofenol reakciója meglepő módon nem a várt 2,4-diszubsztituált 1,5-benzotiazepint eredményezte, henem új típusú 1,5-benzotiazepin keletkezett, melynek ''4'' helyzetében a kumarinszármazék Z-konfigurációju exo kettőskötéssel kapcsolódik. A rekcióban 2-amino-tiofenol helyett 1,2-diamino-benzolt alkalmazva eddig ismeretlen vázrendszerű 10a-aril-1,2,10,10a-tetrahidrobenzo-[4,5]-imidazo[1,2-a]piridin-3-il(2-hidroxifenil)-1-metanon származékok keletkeztek. Elvégeztük a termékek 1H, 13C és 15N jelhozzárendelését is. | Our research project resulted in 49 publications, 23 of them appeared in international journals. The main part of the project have been dealt with the structure elucidation of new compounds isolated from plants applied also in the folk medicine. For the structure determination we utilised mainly the most advanced 1H-detected one- and two-dimensional NMR methods in combination with semiempirical calculations. On the field of the ecdysteroid research we have investigated more the one hundred substances, among them ca. 15 turned to be new natural product. In the joint project with colleagues from Egypt we elucidated the structures of different new flavanol-, iridoide- lignan- triterpene-glycoside and sesquiterpene derivatives. On the field of synthetic natural product analogues the structures of new indole-, indolozino-, isoquinoline- and pyridoindole type alkaloids have been determined. An unprecedented formation of a new type of 1,5-benzothiazepines with exocyclic double bond at position 4 has been achieved by the reaction of 3-aryl-1-(3-coumarinyl)propen-1-ones with 2-aminothiophenol. The reaction of 3-(3-aryl-3-oxopropenyl)chromen-4-ones with 1,2-phenylenediamine resulted in the unexpected formation of 10a-aryl-1,2,10,10a-tetrahydrobenzo-[4,5]-imidazo[1,2-a]pyridine-3-yl(2-hydroxy-phenyl)-1-methanones. Their structure elucidation and complete 1H, 13C and 15N NMR assignments have been performed by a combination of various one- and two-dimensional NMR experiments.
Ethernet over WDM: Optimization for resilience and scalability (2007)

The emerging Ethernet technologies deployed in metro networks provide services based on pure Ethernet. Low cost optical Ethernet interfaces are used to interconnect different sites. Then, the use of wavelength division multiplexing technology with optical Ethernet is clearly the next step in building cost efficient metro networks. In this paper we propose a novel architecture and configuration methods that make metro Ethernet better scale to larger traffic and to covering larger areas that consist of more nodes promising significantly lower costs. The idea is to utilize wavelength paths optimally for bypassing certain Ethernet nodes and by employing traffic grooming according to different strategies we propose and compare. The result is always a tradeoff between the cost of the solution and the achievable throughput. Our methods are based on integer linear program and combinatorial heuristics. The proposed architecture and the optimization framework support very fast recovery upon a failure. Furthermore, it handles the shared risk link groups to ensure that the working and the backup paths should be physically disjoint. The method also supports traffic engineering goals: network utilization and resilience. Furthermore, it can be well used to enforce limitations on the depth and diameter of the obtained logical topology that allows scalability.
Cuticular hydrocarbons for identifying Sarcophagidae (Diptera) (2021)

The composition and quantity of insect cuticular hydrocarbons (CHCs) can be species-specific as well as sexually dimorphic within species. CHC analysis has been previously used for identification and ageing purposes for several insect orders including true flies (Diptera). Here, we analysed the CHC chemical profiles of adult males and females of eleven species of flesh flies belonging to the genus Sarcophaga Meigen (Sarcophagidae), namely Sarcophaga africa (Wiedemann), S. agnata Rondani, S. argyrostoma Robineau-Desvoidy, S. carnaria (Linnaeus), S. crassipalpis Macquart, S. melanura Meigen, S. pumila Meigen, S. teretirostris Pandellé, S. subvicina Rohdendorf, S. vagans Meigen and S. variegata (Scopoli). Cuticular hydrocarbons extracted from pinned specimens from the collections of the Natural History Museum, London using a customised extraction technique were analysed using Gas Chromatography-Mass Spectrometry. Time of preservation prior to extraction ranged between a few weeks to over one hundred years. CHC profiles (1) allowed reliable identification of a large majority of specimens, (2) differed between males and females of the same species, (3) reliably associated males and females of the same species, provided sufficient replicates (up to 10) of each sex were analysed, and (4) identified specimens preserved for up to over one hundred years prior to extraction.
Impact patterns and temporal evolutions of water drops impinging on a rotating disc (2011)

The impact process of a water drop colliding with a rotating disc was recorded and analysed using a high-speed video camera. Four falling velocities of the drop, eight rotational speeds, and four impacting radii of the disc were chosen to study their influences on the outcomes of drop impact. The correlation of the deposition–splash boundary was found to be the function of Reynolds number, Weber number, and Rossby number. Four kinds of impact processes were classified in terms of Rossby number and several new stages of the impact outcomes not present in drop impact on a stationary plate were recognized. For deposition processes, the temporal evolutions of two spread factors, the tangential and radial spread factors, were analysed in detail. It was found that the Rossby number and the falling velocity of the drop are the major factors affecting the tangential spread factor. In contrast, the Rossby number has little effect on the radial spread factor while the falling velocity of the drop still exerts a considerable influence on it.
Using feedback to control tree saturation in multistage interconnection networks (1989)

In this paper, we propose the use of feedback schemes in multiprocessors which use an interconnection network with distributed routing control. We show that by altering system behavior so as to minimize the occurrence of a performance-degrading situation in the network, the overall throughout of the system can be improved. As an example, we have considered the problem of tree saturation caused by hot spots in multistage interconnection networks. Tree saturation degrades the performance of all processors in a system, including those not participating in the hot spot activity. We see that feedback schemes can be used to control tree saturation, reduce degradation to memory requests that are not to the hot memory module and increase overall system bandwidth. As a companion to feedback schemes, damping schemes are also considered. Simulation studies presented in this paper show that feedback schemes can improve overall system performance significantly in many cases.
The first steps of a robot based on jamming skin enabled locomotion (2009)

A soft, controllably morphable mobile robot is an ideal platform for traversing complex terrain and navigating small holes. iRobot Corporation and the University of Chicago have made use of a phenomenon known as particle jamming to create such a robot. The robot presented in this work uses jamming skin cells to enable controlled morphing and locomotion.
Motion detection in a color video sequence with an application to monitoring a baby (2022)

Personal real-time video monitoring devices are popular in recent years especially for people living in bigger houses who are taking care of babies. People take advantage of a real-time video monitoring device to monitor the babies&#x2019; activities while they are occupied by other issues. However, danger happens any time in any situations. It is necessary for a baby monitoring device to have a motion detection function to trigger recording functions or alert the guardians. This paper introduces a solution for the motion detection problem. The solution combines statistical methods, kernel density estimation and histogram analysis methods, and deep learning method for detecting the salient object. The final outputs are both the motion levels indicating the severity of the motions and the bounding boxes indicating the location of the motion happening in the video frame. The different levels of motion can later be used as triggers for different functions built into the device, such as starting video recording, playing sirens, etc., and the bounding boxes can provide reference focus areas for the guardians to check the details of the motion to decide whether to take actions or not.