gebhart/patrepeval huggingface dataset:
Electrophysiologically guided ablation of the pulmonary veins for the curative treatment of atrial fibrillation (2000)

Catheter ablation of triggers that induce paroxysms of atrial fibrillation (AF) is an emerging curative therapy for this most common of supraventricular arrhythmias. In a series of 225 consecutive patients with multidrug resistant AF, 96% of triggering foci originated from one or several pulmonary veins (PV) independent of ambient ectopy or structural heart disease. This article describes an ablation procedure that is guided by activation mapping tailored to each individual PV, including criteria to define an arrhythmogenic PV, the use of provocative manoeuvres, the role of circumferential mapping catheters to provide information on the extent, distribution and activation of PV muscle as well as the monitoring of distal PV potentials (PVP) during ablation. Radiofrequency ablation to eliminate distal PVPs is performed by targeting the proximal PVP during sinus rhythm (right PV) or left atrial pacing (left PV). This end-point predicts a successful outcome more often than acute ectopy suppression. Complete elimination of AF is presently achieved in 70% of the patients, resulting in the elimination of antiarrhythmic treatment and suspension of anticoagulant treatment. It is anticipated that continued technological development will improve and facilitate this technique of curative treatment of AF.
New Architectures for Side Chain Liquid Crystalline Polymers with Chiral Smectic C Mesophases (1994)

Abstract All attempts at synthesizing side chain liquid crystalline polymers (SCLCPs) with chiral smectic C (sc*) mesophases simply functionalize one terminal group of the mesogen with a chiral substituent and attach the other terminus to the polymer backbone through a spacer. If a sc* mesophase is observed, it is usually in the less desirable sc*-sA phase sequence. We propose that SCLCPs with laterally attached (vs terminally attached) mesogens offer an ideal architecture for obtaining sc* meso- phases. This is because extended mesogens symmetrically disubstituted with long n-alkoxy groups can be attached to the polymer backbone through a chiral spacer. Thus, mesogens which typically form the desirable sc*-n phase sequence can be used, and the chiral group can be introduced at the center of the mesogen which should result in high values of spontaneous polarization. We are not only using mesogens which exhibit sc*-n phase sequences, but are also attempting to induce smectic layering into laterally attached systems which typically form nematic mesophases by electron-donor-acceptor interactions and immiscible hydrocarbon/fluorocarbon components. Smectic layering was successfully induced in 2,5-bis[(4'-n-alkoxybenzoyl)oxy]toluenes when the n-alkoxy substituents were terminated with perfluorinated segments.
Cobalt nanoclusters coated with N-doped carbon for chemoselective nitroarene hydrogenation and tandem reactions in water (2021)

Subnanometric cobalt nanoclusters covered by N-doped carbon layers (<bold>Co@NC-800</bold>) catalyze the chemoselective reduction of nitroarenes and the one-pot synthesis of secondary aryl amines and isoindolinones in aquo media under mild reaction conditions.
Workshop on social recommender systems (2010)

This workshop brought researchers from academia and industry together to share recent advances and discuss research directions for recommender systems in social media and Web 2.0. With social media sites becoming ubiquitous, the challenges and opportunities for recommendation technologies become greater, setting the grounds for new research and innovation.
[The influence of polypeptide liver complex and tetrapeptide KEDA on organism physiological function in norm and age-related pathology.] (2020)

The applying of many drugs in elderly and old people often is the reason of liver dysfunction. Thereat, the risk of liver fibroid induration, acute and chronic hepatitis increases during aging. It is the reason to find new, effective and harmless hepatoprotectors. In the review is shown the data of hepatoprotective, immunoprotective and antiageing properties of liver polypeptide complex (Ventvil) and KEDA tetrapeptide (Lys-Glu-Asp-Ala, Livagen). In liver pathology experimental models (liver fibroid induration, acute and chronic hepatitis) in amimals and in vitro was shown high efficiency of Ventvil and KEDA peptide. Ventvil and KEDA peptide had concordant effects - normalized immune and antioxidant status, restored liver function during hepatitis. It was demonstrated, that maximal hepato- and immunoprotective effect of peptides verified in aging.
CT-03 Phase 2 trial of induction therapy with anti-CD20 (rituximab) followed by maintenance therapy with anti-BAFF (belimumab) in patients with active lupus nephritis (2018)

<h3>Background</h3> Despite case series suggesting efficacy, controlled trials of anti-CD20 in lupus nephritis (LN) did not confirm benefit (<i>Arthritis Rheum</i> 2012;64:1215 and 2013;65:2368). <h3>Objectives</h3> One possible explanation for this failure stems from the fact that B cell depletion stimulates production of B cell activating factor (BAFF) which, in turn, facilitates maturation of autoreactive B cells in lymphoid organs or during B cell repopulation. The CALIBRATE study (NCT 02260934) was designed to test this hypothesis, to determine whether addition of anti-BAFF could enhance the clinical effects of anti-CD20, and to assess safety of the combination. <h3>Methods</h3> Forty-three patients with active LN despite conventional treatment enrolled in a prospective randomized open-label trial that compared two treatment strategies. All subjects received iv rituximab (1000 mg), CTX (750 mg), and methylprednisolone (100 mg) at wks 0 and 2, followed by 40 mg/d prednisone tapered to 10 mg/d by wk 12. At wk 4, subjects received either belimumab (10 mg/kg iv at wks 4, 6, 8 and then every 4 wks) plus prednisone (n=21) or prednisone alone (n=22). Complete response (CR) was defined as: (i) urine protein:creatinine ratio (UPCR) &lt;0.5; (ii) eGFR &gt;120 or, if &lt;120, eGFR &gt;80% of screening; and (iii) prednisone tapered to 10 mg/d. The definiton of partial response (PR) differed only in the UPCR criterion (&gt;50% reduction). <h3>Results</h3> The clinical outcome at wk 24 was similar in both groups (table 1). The CR rate was 24% in the belimumab group (RCB) and 23% in the control group (RC). Three subjects in each group withdrew (WD) prior to wk 24 (two withdrawals in each group due either to progressive nephritis or an infusion reaction, and one in each group for reasons unrelated to SLE or its treatment). B cell depletion from blood was virtually absolute in both groups at wk 12, but the pace of recovery differed. Six subjects experienced serious adverse events between wks 0 and 24; three subjects in the RC group (pneumonia followed by LN flare; deep vein thrombosis; SLE flare); and three subjects in the RCB group (anti-CD20 infusion reaction; soft-tissue abscesses prior to anti-BAFF treatment; quadriceps tendon rupture). <h3>Conclusions</h3> An interim analysis of data from CALIBRATE shows: (i) anti-BAFF following anti-CD20 for LN did not improve clinical outcome at week 24; (ii) anti-BAFF delayed blood B cell reconstitution following B cell depletion; and (iii) anti-BAFF following anti-CD20 was not associated with hypogammaglobulinemia or an increase in serious infections. Further analyses at 48 weeks and beyond will address how anti-BAFF therapy affects quantitative and qualitative recovery of B cells as well as long-term clinical outcome. <h3>Acknowledgements</h3> Conducted by ITN with support from NIAID (UM1AI109565) and Genentech. <h3>Trial registration</h3> NCT02260934
Conformational Considerations in the Design of Highly Potent and Long-Acting Peptide Hormone Agonists and Antagonists (1983)

Conformational Considerations in the Design of Highly Potent and Long-Acting Peptide Hormone Agonists and Antagonists was published in 17. Prague, Czechoslovakia, August 29–September 3, 1982 on page 19.
Transgelin-expressing myofibroblasts orchestrate ventral midline closure through TGFβ signalling (2017)

Ventral body wall (VBW) defects are among the most common congenital malformations, yet their embryonic origin and underlying molecular mechanisms remain poorly characterised. Transforming growth factor beta (TGFβ) signalling is essential for VBW closure, but the responding cells are not known. Here, we identify in mouse a population of migratory myofibroblasts at the leading edge of the closing VBW that express the actin-binding protein transgelin (TAGLN) and TGFβ receptor (TGFβR). These cells respond to a temporally regulated TGFβ2 gradient originating from the epithelium of the primary body wall. Targeted elimination of TGFβR2 in TAGLN<sup>+</sup> cells impairs midline closure and prevents the correct subsequent patterning of the musculature and skeletal components. Remarkably, deletion of <i>Tgfbr2</i> in myogenic or chondrogenic progenitor cells does not manifest in midline defects. Our results indicate a pivotal significance of VBW myofibroblasts in orchestrating ventral midline closure by mediating the response to the TGFβ gradient. Altogether, our data enable us to distinguish highly regulated epithelial-mesenchymal signalling and successive cellular migration events in VBW closure that explain early morphological changes underlying the development of congenital VBW defects.
MRI-guided breast image reconstruction with limited frequency domain phase data (2014)

A breast imaging clinical trial involving 60 patients using a MRI-guided frequency domain-continuous wave near infrared spectroscopic tomography system was completed. Optical images were reconstructed with and without frequency domain phase data.
Palbociclib plus endocrine therapy in HER2 negative, hormonal receptor‐positive, advanced breast cancer: A real‐world experience (2018)

Data from 423 human epidermal growth factor receptor 2-negative (HER2-), hormone receptor-positive (HR+) advanced breast cancer (aBC) patients treated with palbociclib and endocrine therapy (ET) were provided by 35 Italian cancer centers and analyzed for treatment outcomes. Overall, 158 patients were treated in first line and 265 in second/later lines. We observed 19 complete responses and 112 partial responses. The overall response rate (ORR) was 31% (95% confidence interval [CI], 26.6-35.4) and clinical benefit was 52.7% (95% CI, 48-57.5). ORR was negatively affected by prior exposure to everolimus/exemestane ( p = 0.002) and favorably influenced by early line-treatment ( p < 0.0001). At 6 months, median progression-free survival was 12 months (95% CI, 8-16) and median overall survival was 24 months (95% CI, 17-30). More favorable outcomes were associated with palbociclib in early lines, no visceral metastases and no prior everolimus/exemestane. The main toxicity reported was neutropenia. Our results provide further support to the use of palbociclib with ET in HER2-, HR+ aBC. Differences in outcomes across patients subsets remain largely unexplained.
Receptor Activator of Nuclear Factor κB Ligand Is a Novel Inducer of Tissue Factor in Macrophages (2010)

Our results indicate that RANKL induces TF in macrophages mainly through the cooperative action of AP-1 and Egr-1 via JNK and ERK1/2 pathways. These findings provide strong mechanistic support for the role of RANKL in the thrombogenicity of atherosclerotic plaques.
Electrical Properties of Undoped 6H- and 4H-SiC Bulk Crystals Grown by Halide Chemical Vapor Deposition (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Adhesion of Nanoparticles (2011)

We have developed a new model of nanoparticle adhesion which explicitly takes into account the change in the nanoparticle surface energy. Using combination of the molecular dynamics simulations and theoretical calculations we have showed that the deformation of the adsorbed nanoparticles is a function of the dimensionless parameter β ∝ γp(GRp)−2/3W−1/3, where G is the particle shear modulus, Rp is the initial particle radius, γp is the polymer interfacial energy, and W is the particle work of adhesion. In the case of small values of the parameter β < 0.1, which is usually the case for strongly cross-linked large nanoparticles, the particle deformation can be described in the framework of the classical Johnson, Kendall, and Roberts (JKR) theory. However, we observed a significant deviation from the classical JKR theory in the case of the weakly cross-linked nanoparticles that experience large shape deformations upon particle adhesion. In this case the interfacial energy of the nanoparticle plays an importa...
Making Privacy a Fundamental Component of Web Resources (2010)

We present a social network inspired and access control list based sharing model for web resources. We have specified it as an extension for OpenSocial 1.0 and implemented a proof of concept in Orkut as well as a mobile social photo sharing application using it. The paper explains important design decisions and how the model can be leveraged to make privacy a core component and enabler for sharing resources on the web and beyond using capabilities of mobile devices.
Long term follow-up analysis of plasma miR371 expression to detect early relapse in patients with clinical stage I testicular germ cell tumors on surveillance. (2023)

5006 Background: Clinical Stage I (CSI) is the most common presentation of germ cell testicular tumors (GCT) and patients are usually managed with active surveillance, in absence of reliable biomarkers of relapse. Circulating plasma miR371a-3p (miR371) has demonstrated high sensitivity and specificity in advanced non teratoma GCT. However, its operating characteristics and power to detect early relapse are still undefined. Methods: CSI GCT patients enrolled in the British Columbia provincial biobank with available plasma samples after radical orchiectomy were included in this study. Plasma miR371 was qualitatively assessed by RT-PCR. Sensitivity, specificity, negative and positive predictive values (NPV, PPV) and AUC in predicting tumor recurrence were evaluated in the post-orchiectomy blood samples and/or during the follow-up prior to or at the time of the clinically evident relapse. Relapse free survival (RFS) was correlated to post-orchiectomy miR371 status. Results: One-hundred-one patients were analyzed, 35 (34.6%) experienced a disease relapse with a median follow-up of 41 months. miR371 was positive in 22/35 of the relapsed patients. The specificity and PPV were 100% (95% CI: 94.5 - 100 for both), sensitivity 62.8% (95% CI: 44.9 - 78.5), NPV 83.5% (95%CI: 76.7 - 88.6) and AUC 0.81 (95% CI: 0.71 - 0.91). No false positive results were observed. The RFS of the patients with positive post-orchiectomy miR37 was significantly shorter (median: 3.5 months vs. not reached; p&lt;0.0001) compared to the patients with a negative post-orchiectomy miR371 (HR: 16.9; 95% CI: 2.1 - 135.7; p&lt;0.0001). miR371 sensitivity correlated with tumor burden, time between tumor relapse and miRNA testing and histology (nonseminoma &gt; seminoma). Conclusions: miR371 has high specificity and PPV in detecting GCT at an early stage and could be used to predict GCT relapse during surveillance and to guide treatment selection after orchiectomy. Further studies have been planned for validation of miR371 clinical utility.
Direct observation of optical magnetism from a dielectric resonator metamaterial using time-domain spectroscopy in the mid-infrared (2012)

We use phase-locked time-domain spectroscopy in the mid-infrared to directly demonstrate the “infrared magnetic mirror” behavior of an all-dielectric metamaterial. This metamaterial surface consists of micron-sized cubes of tellurium fabricated on a dielectric substrate.
Impaired ATP turnover and ADP supply depress cardiac mitochondrial respiration and elevate superoxide in nonfailing spontaneously hypertensive rat hearts (2009)

Although most attention has been focused on mitochondrial ATP production and transfer in failing hearts, less has been focused on the nonfailing hypertensive heart. Here, energetic complications are less obvious, yet they may provide insight into disease ontogeny. We studied hearts from 12-mo-old spontaneously hypertensive rats (SHR) relative to normotensive Wistar-Kyoto (WKY) rats. The ex vivo working-heart model of SHR showed reduced compliance and impaired responses to increasing preloads. High-resolution respirometry showed higher state 3 (with excess ADP) respiration in SHR left ventricle fibers with complex I substrates and maximal uncoupled respiration with complex I + complex II substrates. Respiration with ATP was depressed 15% in SHR fibers relative to WKY fibers, suggesting impaired ATP hydrolysis. This finding was consistent with a 50% depression of actomyosin ATPase activities. Superoxide production from SHR fibers was similar to that from WKY fibers respiring with ADP; however, it was increased by 15% with ATP. In addition, the apparent K(m) for ADP was 54% higher for SHR fibers, and assays conducted after ex vivo work showed a 28% depression of complex I in SHR, but not WKY, fibers. Transmission electron microscopy showed similar mitochondrial volumes but a decrease in the number of cristae in SHR mitochondria. Tissue lipid peroxidation was also 15% greater in SHR left ventricle. Overall, these data suggest that although cardiac mitochondria from nonfailing SHR hearts function marginally better than those from WKY hearts, they show dysfunction after intense work. Impaired ATP turnover in hard-working SHR hearts may starve cardiac mitochondria of ADP and elevate superoxide.
Impact of Age and Sex on Cardiovascular Magnetic Resonance Measurements (2020)

sponsorship: The authors gratefully acknowledge the study oversight provided by Ms. Stavroula Raptis. Dr. Wald was supported by the Canadian Institutes of Health Research (MOP 119353). Dr. McCrindle has been a consultant and investigator for Janssen; and has been an investigator for Mezzion. Dr. Farkouh has received research grants from Amgen and Novo Nordisk. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors' institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC: Cardiovascular Imaging https://imaging.onlinejacc.org/content/instructions-authors. (Canadian Institutes of Health Research|MOP 119353)
Oligonucleotide Therapeutics (2003)

Abstract Antisense technology expolits oligonucleotide analogs to bind to cognate RNA sequences through Watson‐Crick hybridization resulting in the destruction or disablement of the target RNA. Durign the past decade, programs on all fronts has continued and there are satisfactory consensus to all the basic questions. In this review, progress in the medicinal chemistry and molecular pharmacology of antisense is reviewed. Further, progress in understanding thepharmacokinetic, pharmacodynamic and toxicologic properties of first and second generations antisense drugs is reviewed. Additionally, a summary of clinical data on a significant number of antisense drugs is provided.
Microscope-integrated Optircal Coherence Tomography Accurately Predicts Anastomotic Patency (2022)

Background: Optical Coherence Tomography (OCT) uses low-coherence, long-wavelength light to penetrate different media and acquire high-resolution, cross-sectional images. Utilized widely in ophthalmology, OCT has yet to be routinely employed by plastic surgeons. We hypothesized that a microscope-integrated OCT platform could be used to scan through microvascular anastomoses and assess for vessel patency. Methods: Twenty anastomoses were created using 3mm synthetic vessels (10 patent anastomoses and 10 intentionally flawed anastomoses). The flawed anastomoses were created by deliberately suturing a 1mm-x-1mm piece of synthetic vessel within the lumen. The anastomoses were performed with 8-0 nylon suture using an operative microscope (6 interrupted sutures per anastomosis). The 20 anastomoses were then individually rated by 3 blinded reviewers as “patent” or “flawed,” first by visual examination, then by OCT. Results: For patent vessels, visual examination yielded a 33.33% accuracy (+/- 48.04 SD). When OCT scans were used, accuracy increased to 93.33% (+/- 25.38 SD). For flawed vessels, visual examination yielded a 25.93% accuracy (+/- 44.67 SD). When using OCT scans, accuracy increased to 90.00% (+/- 30.51 SD). Between imaging modalities (visual versus OCT), the difference in accuracy was statistically significant (p<.001). The inter-rater reliability was 0.76. Conclusions: This study demonstrates that OCT is effective in predicting vessel patency in an in-vitro model. This technology can potentially be adopted in microsurgery to improve clinical outcomes by allowing visualization of anastomoses performed in the operating room.
A Note on Denavit-Hartenberg Notation in Robotics (2005)

The Denavit-Hartenberg conventions model chains of bodies connected by joints. Originally they were applied to single-loop chains but are now almost universally applied to open-loop serial chains such as robotic manipulators. Unfortunately there are several popular variations of the notation: the original, the distal variant, and the proximal variant. These three cases are compared for their application to serial robots. The proximal variate is advanced as the most notationally transparent for the mechanical analysis of serial manipulators.
Polymerization shrinkage stress of composite resins and resin cements – What do we need to know? (2017)

Polymerization shrinkage stress of resin-based materials have been related to several unwanted clinical consequences, such as enamel crack propagation, cusp deflection, marginal and internal gaps, and decreased bond strength. Despite the absence of strong evidence relating polymerization shrinkage to secondary caries or fracture of posterior teeth, shrinkage stress has been associated with post-operative sensitivity and marginal stain. The latter is often erroneously used as a criterion for replacement of composite restorations. Therefore, an indirect correlation can emerge between shrinkage stress and the longevity of composite restorations or resin-bonded ceramic restorations. The relationship between shrinkage and stress can be best studied in laboratory experiments and a combination of various methodologies. The objective of this review article is to discuss the concept and consequences of polymerization shrinkage and shrinkage stress of composite resins and resin cements. Literature relating to polymerization shrinkage and shrinkage stress generation, research methodologies, and contributing factors are selected and reviewed. Clinical techniques that could reduce shrinkage stress and new developments on low-shrink dental materials are also discussed.