gebhart/patrepeval huggingface dataset:
Degradation Behavior of Lithium-Ion Batteries Based on Lifetime Models and Field Measured Frequency Regulation Mission Profile (2016)

Energy storage systems based on Lithium-ion (Li-ion) batteries have been proposed as an environmentally friendly alternative to traditional conventional generating units for providing grid frequency regulation. One major challenge regarding the use of Lithium-ion batteries in such applications is their higher cost-in comparison with other storage technologies or with the traditional frequency regulation methods-combined with performance-degradation uncertainties. In order to surpass this challenge and to allow for optimal sizing and proper operation of the battery, accurate knowledge about the lifetime of the Li-ion battery and its degradation behavior is required. Thus, this paper aims to investigate, based on a laboratory developed lifetime model, the degradation behavior of the performance parameters (i.e., capacity and power capability) of a Li-ion battery cell when it is subjected to a field measured mission profile, which is characteristic for the primary frequency regulation service.
Temperature dependent carrier lifetime measurements of InAs/InAsSb T2SLs (2015)

Temperature dependent measurements of carrier recombination rates using a time-resolved pump-probe technique are reported for mid-wave infrared InAs/InAsSb type-2 superlattices (T2SLs). By engineering the layer widths and alloy compositions a 16 K band-gap of ~235 &plusmn; 10meV was achieved for four doped and five undoped T2SLs. Carrier lifetimes were determined by fitting lifetime models of Shockley-Read-Hall (SRH), radiative, and Auger recombination processes simultaneously to the temperature and excess carrier density dependent data. The contribution of each recombination process at a given temperature is identified and the total lifetime is determined over a range of excess carrier densities. The minority carrier and Auger lifetimes were observed to increase with increasing antimony content and decreasing layer thickness for the undoped T2SLs. It is hypothesized that a reduction in SRH recombination centers or a shift in the SRH defect energy relative to the T2SL band edges is the cause of this increase in the SRH minority carrier lifetime. The lower Auger coefficients are attributed to a reduced number of final Auger states in the SL samples with greater antimony content. An Auger limited minority carrier lifetime is observed for the doped T2SLs, and it is found to be a factor of ten shorter than for undoped T2SLs. The Auger rates for all the InAs/InAsSb T2SLs were significantly larger than those previously reported for InAs/GaSb T2SLs.
WARPY: Sketching Environment-Aware 3D Curves in Mobile Augmented Reality (2023)

Three-dimensional curve drawing in Augmented Reality (AR) enables users to create 3D curves that fit within the real-world scene. It has applications in 3D design, sculpting, and animation. However, the task complexity increases when the desirable path for the curve is obstructed by the physical environment or by what the camera can see. For example, it is difficult to draw a curve that wraps around an object or scales to out-of-reach places. We propose WARPY, an environment-aware 3D curve drawing tool for mobile AR. Our system enables users to draw freeform curves from a distance in AR by combining 2D-to-3D sketch inference with geometric proxies. Geometric Proxies can be obtained via 3D scanning or from a list of pre-defined primitives. WARPY also provides a multi-view mode to enable users to sketch a curve from multiple viewpoints, which is useful if the target curve cannot fit within the camera's field of view. We conducted two user studies and found that WARPY can be a viable tool to help users create complex and large curves in AR.
Angiotensin converting enzyme inhibiting and anti-dipsogenic activities ofEuphorbia hirta extracts (1997)

The methanol extract obtained from the leaves and stems of Euphorbia hirta inhibited the activity of angiotensin converting enzyme (ACE) by 90% and 50% at 500 μg and 160 μg respectively using enzyme linked immunosorbent assay (ELISA). The effect of the extract on thirst was examined using Wistar rats. Intraperitoneal administration of 10 mg/100 mg body wt of the extract significantly (p <0.05) decreased the amount of water consumed by rats. This effect lasted for 2 h. © 1997 John Wiley & Sons, Ltd.
A novel ultra-wideband signal acquisition scheme using multiple correlator outputs jointly (2011)

This paper proposes a novel two-stage detection scheme using multiple correlator outputs jointly to enhance the detection performance in ultra-wideband (UWB) signal acquisition. Due to the rich multipath of UWB channels, the signal energy spreads over multiple correlator outputs, which makes each correlator output have only a portion of the signal energy, and thus, degrades the detection performance of the conventional scheme where a single correlator output is used as the decision variable for detection. In the proposed two-stage detection scheme, the decision variable is formed by combining multiple correlator outputs, making it possible to collect the signal energy spread by the multipath. Simulation results show that the proposed scheme can provide a better detection performance over the conventional scheme in various UWB channel environments.
Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO (2008)

An inducible model for conditional expression of AML1-ETO in myeloid U-937 cells was generated previously to determine cellular effects of AML1-ETO and to identify target genes. Induction of AML1-ETO expression in U-937 resulted in reduced cell growth, G1 arrest and apoptosis. Microarray analysis showed more genes up-regulated than down-regulated (180 vs. 69). Clustering of AML1-ETO-positive and -negative cell lines was possible based on these differentially expressed genes. p21/WAF/Cip1 (CDKN1A) was up-regulated 4.6-fold upon induction of AML1-ETO which was confirmed in additional experiments. Knock-down of AML1-ETO by siRNA could reduce p21/WAF/Cip1 expression in Kasumi-1 cells. mRNA expression analysis of p21/WAF/Cip1 in a large cohort of acute myeloid leukemia patients demonstrated a significantly higher expression in AML1-ETO-positive leukemia. The increased expression of p21/WAF/Cip1 in primary leukemic blasts suggests that elevated p21/WAF/Cip1 levels may contribute to specific features observed in AML1-ETO positive leukemia.
Figure S1 from Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction (2023)

&lt;p&gt;Impairment of death receptor signaling results in resistance to CART19.&lt;/p&gt;
Ag MESH, a peritrophic matrix-associated protein embedded in Anopheles gambiae melanotic capsules modulates malaria parasite infection (2021)

Abstract Melanins are structurally complex pigments produced by organisms in all domains of life. In insects, melanins are essential for survival and have key roles in cuticle sclerotization, wound healing and innate immunity. In this study, we used a diverse set of molecular, biochemical, and imaging approaches to characterize mosquito melanin involved in innate immune defense (melanotic capsules). We observed that melanotic capsules enclosing Plasmodium berghei ookinetes were composed of an acid-resistant and highly hydrophobic material with granular appearance, which are characteristic properties of melanins. Spectroscopical analyses reveal chemical signatures of eumelanins and pheomelanin. Furthermore, we identified a set of 14 acid-resistant mosquito proteins embedded within the melanin matrix possibly related to an anti- Plasmodium response. Among these, Ag MESH, a mucin-related protein highly conserved among insects that is associated with the midgut brush border microvilli proteome of Anopheles gambiae and A. albimanus. AgMESH gene silencing in mosquitos was associated with reduced Plasmodium parasite infection, compromised integrity of the peritrophic matrix, and inability to synthesize a dityrosine network. Our results provide a new approach to study aspects of insect melanogenesis that revealed proteins associated with melanotic capsule, one of which was strongly implicated in the stabilization of the peritrophic matrix and pathogenesis of Plasmodium spp. mosquito infection. Given the conservation of Ag MESH among disease-transmitting insect vector species, future analysis of this protein could provide fertile ground for the identification of strategies that block transmission of vector borne diseases to humans. Significance Statement Malaria is a parasitic disease transmitted by mosquito bites. Here, we adapt methodologies to study fungal melanogenesis to explore the melanin-based immune response of Anopheles gambiae against malaria parasites. We reveal that melanotic capsules against Plasmodium are composed of pheomelanin and eumelanin. We demonstrate that melanin-encapsulated Plasmodium is associated to acid-resistant mosquito gut proteins and identify several putative factors of the melanin-mediated immunity. Disruption of Ag MESH, a surface-associated protein conserved among other mosquito vectors, demonstrates its ability to impaired formation of the dityrosine network and peritrophic matrix compromising parasite development within the mosquito gut. Our study provides a new approach to investigate the melanin-based defense mechanism in insects and identified a potential host molecule for developing novel universal vector-control schemes.
Modeling of the boost power factor correction rectifier in mixed conduction mode using PWA approximation (2008)

PFC converters for higher power are commonly designed for continuous conduction mode (CCM). However, at light load, discontinuous conduction mode (DCM) will appear close to the crossover of the line voltage, causing the converter to switch between the two conduction modes. As a result, the converter dynamics change abruptly, producing input current distortion. In this article a piecewise affine approximation has been employed in modeling a boost power factor correction converter operated in the mixed conduction mode. This approach makes the new model very useful in large signal analysis of PFC rectifiers and design of controller. The results obtained from the proposed model are compared with those of linear approximation and the exact nonlinear model.
TD-PSOLA VE EL I SYNTHESIS (1998)

In an effort to select a speech representation for our 'next generation concatenative text-to-speech synthesizer, the use of two candidates is investigated; TD-PSOLA and the Harmonic plus Noise Model, HNM. A formal listening test has been conducted and the two candidates have been rated regarding intelligibility, naturalness and pleasantness. Ability for database compression and computational load is also discussed. The results show that HNM consistently outperforms TD-PSOLA in all the above features except for computational load. HNM allows for high-quality speech synthesis without smoothing problems at the segmental boundaries and without buzziness or other oddities observed with TDPSOLA.
Assessment of patient-reported outcomes (PROs) and longer-term adverse events (AEs) in phase I study of 225Ac-J591-PSMA for metastatic castration-resistant prostate cancer (mCRPC). (2022)

77 Background: Prostate Specific Membrane Antigen (PSMA) is a conserved cell surface protein in PC and is used for targeted imaging and therapeutics. Antibodies circulate longer than small molecules and are less likely to reach luminal PSMA on normal organs. Here we report PROs and longer-term AEs from the dose-escalation and expansion cohorts of a first-in-human study of combined monoclonal antibody and potent alpha emitter (225Ac-J591). Methods: Eligible subjects with mCPRC were administered 225Ac-J591. Initial to maximum doses were 13.3 to 93.3 KBq/kg). AEs are reporting using CTCAE v5 and PROs, including pain (BPI-SF) and quality of life (QOL, FACT-P), and associations with PSA response were also examined. Results: A total of 32 subjects (one enrolled in both dose-escalation and expansion) were treated with a single dose of 225Ac-J591 across 7 dose levels with expansion at the level (93.3 KBq/kg, n = 16). Median age 69.5 (52-89) and PSA 149.1 (4.8-7168.4). All subjects had at least 1 AE of any grade. Most common were fatigue (31/32, 1 Gr &gt; 2), anorexia (25/32, all Gr 1-2), and thrombocytopenia (25/32, 3 Gr 3, 2 Gr 4). Xerostomia was observed in 14/32 subjects (all Gr 1), 7 of whom had prior 177Lu-PSMA. Pain flare was reported in 43% (17/32) subjects (11 Gr 1, 6 Gr 2). 19 had evaluable PROs at baseline and efficacy visit (week 12). Pain severity (p = 0.8) and interference from pain (p = 0.4) were unchanged from baseline to 12 weeks, yet better PSA response (by percent) was associated with reduced pain severity (r = 0.7, p = 0.0023). Despite at least one AE in each subject, total FACT-P was not significantly changed after treatment (p = 0.2), but emotional well-being declined over time (15 [10.0, 18.0] v 10.0 [7.5, 13.0], p = 0.011). Reduction in median emotional well-being reached clinically important score differences. When stratified by AE, subjects with xerostomia had lower FACT-P total scores, but no difference was observed between those with and without pain. PSA response was not associated with change in QOL or subscales. Conclusions: Pain and quality of life in subjects with mCRPC did not change, on average, from baseline to 12 weeks after treatment with 225Ac-J591. This is despite preliminary evidence of clinical efficacy being accompanied by frequent, treatment emergent AEs. A promising trend toward improved pain in those with PSA response warrants further analysis. Small numbers limited statistical power for testing other subgroup associations. Additional correlations with pretreatment sites of disease, performance status, and adverse event distribution are ongoing. Assessment of changes in PROs in the follow up studies [NCT04506567] are underway. Clinical trial information: NCT03276572.
Unraveling the Mechanisms of Endogenous Tissue Restoration after Bioresorbable Pulmonary Valve Implantation in Sheep (2020)

Objective: Endogenous Tissue Restoration (ETR) utilizes the regenerative response of the human body to transform an off-the-shelf available, synthetic, absorbable graft into a living functional valve. Recent preclinical studies have shown the principle of ETR for heart valve grafts to be promising1Bennink G Torri S Brugmans M et al.A novel restorative pulmonary valved conduit in a chronic sheep model: Mid-term hemodynamic function and histologic assessment.J Thorac Cardiovasc Surg. 2018; 155 (doi:10.1016/j.jtcvs.2017.12.046.): 2591-2601Google Scholar,2Kluin J Talacua H Smits AIPM et al.In situ heart valve tissue engineering using a bioresorbable elastomeric implant – From material design to 12 months follow-up in sheep.Biomater. 2017; 125 (doi:10.1016/j.biomaterials.2017.02.007.): 101-117Google Scholar. However, further detailed knowledge on the underlying mechanisms of the material-driven regenerative response remains elusive. The goal of the present study was to gain a mechanistic understanding of these processes by histopathological analysis of ETR heart valves. Methods: In this study, Xeltis Pulmonary Valved Conduits (XPV, Xeltis B.V., Eindhoven, The Netherlands) implanted in an ovine model were analyzed. Explanted valves (follow-up time: 2, 6, 12 (N=5 per timepoint) and 24 months (N=2)) were embedded in paraffin and sectioned longitudinally. Spatiotemporal analysis was performed using a comprehensive sheep-specific antibody panel3Dekker S van Geeman D van den Bogaerdt AJ et al.Sheep-specific immunohistochemical panel for the evaluation of regenerative and inflammatory processes in tissue-engineered heart valves.Front. Cardiovasc. Med. 2018; 5 (doi:10.3389/fcvm.2018.00105.): 105Google Scholar. Results: Detailed knowledge on graft absorption as well as neo-tissue formation and a better understanding of cellular influences was obtained. Interestingly, foreign body giant cells were located within the graft material at iNOS-rich degradation and tissue remodeling sites in the hinge region of the leaflet, starting as early as 2 months after implantation. In the conduit material, on the other hand, foreign body giant cells remained on the outer layers with only limited infiltration into the scaffold material. Interestingly, at the same time point vascularization was observed throughout the conduit material. Extracellular matrix components, such as collagens and elastin were formed in a highly heterogeneous fashion, suggesting an important role for hemodynamic loads on the inflammatory and regenerative processes. Conclusions: Our results enhance the mechanistic understanding of material-driven endogenous tissue restoration. These findings also highlight, the importance of the micro-environment imposed by the graft material on the regenerative response towards a biomaterial. KEYWORD: ICTEHV-O-02 The authors do not declare any conflict of interest.
Durch direkte arylierende Polykondensation zu halbleitenden Polymeren (2012)

Neue Wege zu umweltfreundlichen und kostengünstigen optoelektronischen Bauteilen können halbleitende π-konjugierte Polymere eröffnen. Diese Materialien sind durch direkte arylierende Polykondensation zugänglich, einem unkomplizierten Ansatz, der wenig Abfall und keine toxischen Begleitprodukte liefert.
Supplementary Figure Legends 1-4 from <i>Pten</i> Inactivation Accelerates Oncogenic <i>K-ras</i>–Initiated Tumorigenesis in a Mouse Model of Lung Cancer (2023)

Supplementary Figure Legends 1-4 from &lt;i&gt;Pten&lt;/i&gt; Inactivation Accelerates Oncogenic &lt;i&gt;K-ras&lt;/i&gt;–Initiated Tumorigenesis in a Mouse Model of Lung Cancer
First Measurement of Charm Production in its Fixed-Target Configuration at the LHC (2019)

The first measurement of heavy-flavor production by the LHCb experiment in its fixed-target mode is presented. The production of J/ψ and D^{0} mesons is studied with beams of protons of different energies colliding with gaseous targets of helium and argon with nucleon-nucleon center-of-mass energies of sqrt[s_{NN}]=86.6 and 110.4 GeV, respectively. The J/ψ and D^{0} production cross sections in pHe collisions in the rapidity range [2, 4.6] are found to be σ_{J/ψ}=652±33(stat)±42(syst) nb/nucleon and σ_{D^{0}}=80.8±2.4(stat)±6.3(syst) μb/nucleon, where the first uncertainty is statistical and the second is systematic. No evidence for a substantial intrinsic charm content of the nucleon is observed in the large Bjorken-x region.
Data from Characterization of CD33/CD3 Tetravalent Bispecific Tandem Diabodies (TandAbs) for the Treatment of Acute Myeloid Leukemia (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Randomized studies with gemtuzumab ozogamicin have validated CD33 as a target for antigen-specific immunotherapy of acute myelogenous leukemia (AML). Here, we investigated the potential of CD33/CD3-directed tandem diabodies (TandAbs) as novel treatment approach for AML. These tetravalent bispecific antibodies provide two binding sites for each antigen to maintain the avidity of a bivalent antibody and have a molecular weight exceeding the renal clearance threshold, thus offering a longer half-life compared to smaller antibody constructs.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We constructed a series of TandAbs composed of anti-CD33 and anti-CD3 variable domains of diverse binding affinities and profiled their functional properties in CD33&lt;sup&gt;+&lt;/sup&gt; human leukemia cell lines, xenograft models, and AML patient samples.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Our studies demonstrated that several CD33/CD3 TandAbs could induce potent, dose-dependent cytolysis of CD33&lt;sup&gt;+&lt;/sup&gt; AML cell lines. This effect was modulated by the effector-to-target cell ratio and strictly required the presence of T cells. Activation and proliferation of T cells and maximal AML cell cytolysis correlated with high avidity to both CD33 and CD3. High-avidity TandAbs were broadly active in primary specimens from patients with newly diagnosed or relapsed/refractory AML &lt;i&gt;in vitro&lt;/i&gt;, with cytotoxic properties independent of CD33 receptor density and cytogenetic risk. Tumor growth delay and inhibition were observed in both prophylactic and established HL-60 xenograft models in immunodeficient mice.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our data show high efficacy of CD33/CD3 TandAbs in various preclinical models of human AML. Together, these findings support further study of CD33/CD3 TandAbs as novel immunotherapeutics for patients with AML. &lt;i&gt;Clin Cancer Res; 22(23); 5829–38. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Test chamber for determining damage thresholds for high-amplitude underwater sound exposure in animal models (1998)

In order to determine the effects of low-frequency underwater sound on small animal models it is desirable to expose them to well-characterized fields which closely simulate the (locally) plane-wave open ocean stimulus. It is also desirable to produce pure pressure and acceleration stimuli to isolate the effects of the individual components of the acoustic plane wave. It is necessary to produce sufficiently strong signals to enable damage thresholds to be determined. The range of frequencies over which such stimuli must be produced is quite broad since it must include the actual band of interest (100–500 Hz) to examine damage on a cellular and tissue level, as well as at scaled frequencies (∼1–5 kHz) to examine the effects of organ structure. The problem is subtler than one might imagine because of the high compliance of the test animals due to the air in their lungs. The lungs will drastically alter the acoustic field in the chamber and change the loading on the sources and the chamber could alter the vibrational response of the lung. Careful consideration is required to ascertain what is required of the chamber to assure valid measurements and to determine the true effective sound pressure level.
Abstract 14111: Feasibility of Therapeutic Ultrasound Delivery for the Treatment of Mitral Stenosis (2021)

Introduction: Currently, the only disease-modifying therapy for degenerative mitral stenosis (DMS) due to mitral annular calcification (MAC) is open surgical valve repair or replacement, but it is technically challenging, and patients with DMS are often at elevated risk of surgical complications. As such, there is an unmet need for less-invasive strategies to treat DMS. Given the ability of shock-wave grade therapeutic ultrasound to disrupt calcifications, we set out to determine whether therapeutic ultrasound may be a possible treatment strategy for DMS. Hypothesis: This study aimed to evaluate whether ex vivo histotripsy can produce internal disruption of calcified nodules in the mitral annulus, a precursor to improving valve function in DMS. Methods: All experiments were performed on a formalin-fixed human cadaveric heart with severe MAC (Figure 1 A). Histotripsy cavitation was directed at calcified nodules utilizing a sonic concepts HIFUPlex Focused 128 element,1.1MHz array therapy transducer (Figure 1 E). B-mode ultrasound imaging was used to guide therapy. Transducer settings were PRF: 60 Hz, Duty cycle: 8x10^-4, transmit frequency: 1.1 MHz, HIFU Voltage: 60 V, resulting in an estimated pressure output of 34.6 MPa_pk. Results: A total of three histotripsy experiments were performed on the primary dominant calcium nodule. Visual assessment of treatment X-ray microtomography (Micro-CT) revealed qualitative fracturing of the calcified nodule from baseline (Figure 1 B), after the first treatment (Figure 1 C), and after three treatments (Figure 1 D). Gross visual inspection and Micro-CT demonstrated no changes to the surrounding fibrous annulus. Conclusions: In a feasibility study involving a fixed cadaveric heart, histotripsy therapeutic ultrasound demonstrated the potential to internally disrupt a MAC nodule without injuring the mitral annulus. Further studies are needed to address the ability of histotripsy to improve valve function in DMS.