gebhart/patrepeval huggingface dataset:
Highly Stereoselective Synthesis of a Chiral Methyl Group by a Facially Controlled Sigmatropic [1,5]-Hydrogen Shift (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTHighly Stereoselective Synthesis of a Chiral Methyl Group by a Facially Controlled Sigmatropic [1,5]-Hydrogen ShiftChristoph Dehnhardt, Matthew McDonald, Sungsook Lee, Heinz G. Floss, and Johann MulzerView Author Information Institut für Organische Chemie, Universität Wien Währinger Strasse 38, Vienna, Austria Department of Chemistry, Box 351700 University of Washington Seattle, Washington 98195-1700 Cite this: J. Am. Chem. Soc. 1999, 121, 46, 10848–10849Publication Date (Web):November 6, 1999Publication History Received15 July 1999Published online6 November 1999Published inissue 1 November 1999https://pubs.acs.org/doi/10.1021/ja992498ehttps://doi.org/10.1021/ja992498erapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1117Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical reactions,Hydrocarbons,Molecular structure,Organic acids,Rearrangement Get e-Alerts
Primary open angle glaucoma treated by high intensity focused ultrasound (HIFU): results at 18 months of a prospective pilot study on patients treated with the 2nd generation probe (2016)

Purpose To assess the safety and efficacy of Ultrasound Ciliary Plasty (UCP procedure) using HIFU (high intensity focused ultrasound) with a second‐generation probe which increases the treatment surface area and the firing duration in patients with primary open angle glaucoma. Methods Prospective clinical series performed in two University Hospitals, on twenty eyes of twenty patients with primary open‐angle glaucoma, treated with the EyeOP1 medical device equipped with six miniaturized cylindrical piezoelectric transducers of a new generation with an increased lesion volume. All eyes were treated with an 8‐s exposure time per transducer. The main assessment criteria were safety and efficacy measured by the incidence of complications and IOP reduction. Ophthalmic examination and ultrasound biomicroscopy were performed before treatment and during clinical follow‐up at D7, M1, M3, M6, M12, M18 and M24. Results No major intra‐ or post‐operative complications were observed during follow‐up period. Clinical examination showed no lesions of ocular structures other than the ciliary body and no or few signs of intraocular inflammation after treatment. The mean intraocular pressure was significantly reduced from 29.1 ± 5.4 mmHg before treatment to 17.8 ± 6.2 mmHg at last follow‐up. Five patients have needed a second ultrasound procedure and two patients a third procedure. With a mean follow‐up of 18 months, success rate, as defined by an IOP reduction &gt;20% after one or more UCP procedures was 67%. The mean IOP reduction achieved in responding patients was 44%. Conclusions Coagulation of the ciliary body using high intensity focused ultrasound carried out with the new‐generation of miniaturized transducers is a simple, well‐tolerated procedure which enables to significantly reduce the intraocular pressure in patients with Open Angle Glaucoma.
Study of Dy-doped Bi2Te3: thin film growth and magnetic properties (2015)

Breaking the time-reversal symmetry (TRS) in topological insulators (TIs) through ferromagnetic doping is an essential prerequisite for unlocking novel physical phenomena and exploring potential device applications. Here, we report the successful growth of high-quality (Dy(x)Bi(1-x))2Te3 thin films with Dy concentrations up to x = 0.355 by molecular beam epitaxy. Bulk-sensitive magnetisation studies using superconducting quantum interference device magnetometry find paramagnetic behaviour down to 2 K for the entire doping series. The effective magnetic moment, μeff, is strongly doping concentration-dependent and reduces from ∼12.6 μ(B) Dy(-1) for x = 0.023 to ∼4.3 μ(B) Dy(-1) for x = 0.355. X-ray absorption spectra and x-ray magnetic circular dichroism (XMCD) at the Dy M4,5 edge are employed to provide a deeper insight into the magnetic nature of the Dy(3+)-doped films. XMCD, measured in surface-sensitive total-electron-yield detection, gives μ(eff )= 4.2 μ(B) Dy(-1). The large measured moments make Dy-doped films interesting TI systems in which the TRS may be broken via the proximity effect due to an adjacent ferromagnetic insulator.
Heteronuclear two-dimensional NMR as a conformational probe of cellular phosphates (1979)

Heteronuclear 2-dimensional NMR was used to correlate the 1H and 31P chem. shifts of cellular phosphates. Exptl. spectra agree with theor. predictions based on a novel approach using subspectral anal. The spectra are sensitive to the homonuclear scalar couplings between the protons as well as the heteronuclear 1H-31P coupling. Thus, the 2-dimensional spectra provide information about the conformation of cellular phosphates. Since 1H signals are only obsd. from those protons located in the vicinity of the phosphate groups, the signals are referred to as local-proton spectra. [on SciFinder (R)]
BigNum : un module portable et efficace pour une arithmetique a precision arbitraire (1989)

Résumé disponbile dans les fichiers attachés
Dual Universal Peptide Approach to Bioanalysis of Human Monoclonal Antibody Protein Drug Candidates in Animal Studies (2013)

Improvements reported herein to the universal peptide assay will enable more reliable quantification of human monoclonal antibody protein drug candidates in animal studies.
Phase II study combining personalized dendritic cell (DC)-based therapy, AGS-003, with sunitinib in metastatic renal cell carcinoma (mRCC). (2012)

348 Background: AGS-003 is a personalized immunotherapy that employs autologous DCs co-electroporated with the subject’s amplified tumor mRNA and synthetic CD40L RNA. Based on previous results with single agent AGS‐003 and acceptance of TKIs as the standard of care for mRCC, AGS-003 was evaluated in combination with sunitinib as initial treatment for advanced RCC. Progression free survival (PFS) results for the combination have been previously presented and show improvement compared to historical data in unfavorable risk patients treated with sunitinib alone. Methods: AGS-003-006 is an open label phase II study that included subjects with newly diagnosed, metastatic clear cell RCC. Tumor was harvested by nephrectomy or metastasectomy for mRNA. Autologous monocytes were collected by leukapheresis for the production of DCs. Subjects subsequently received sunitinib (4wks on, 2wks off) combined with AGS-003 (every 3wks X 5 doses, then every 12wks) until progression. AGS-003 doses consisted of 1 X 10 7 cells administered by intradermal injection to a single lymph node basin. Response was evaluated per RECIST and subjects followed for PFS and OS. Immune responses were assessed at baseline and after five AGS-003 doses using multiparametric flow cytometry. Results: 25 subjects were enrolled; 21 received treatment. The median PFS from registration for subjects receiving at least one dose of AGS-003 was 11.9 months. For subjects with 1–2 MSKCC risk factors (intermediate risk), PFS = 14.9 months and for subjects with 3–4 MSKCC risk factors (poor risk), PFS = 6.0 months. Median OS from registration has not been reached. Median OS for poor risk subjects = 7.9 months. Median OS for intermediate risk subjects has yet to be reached, but will exceed 28.3+ months. Conclusions: AGS-003 is well tolerated with no immunotherapy-related SAEs or grade 3/4 AEs reported. Interim data indicate that AGS-003 in combination with sunitinib yields a median OS higher than that reported for sunitinib alone in unfavorable risk subjects. Updated OS and immune response correlates will be presented. These results support the ongoing, randomized phase III ADAPT study.
ChemInform Abstract: Thermal and Photochemical Isomerization of Tetraaryl Tetrakis(trifluoromethyl)[4]radialenes. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lensless sensor system using a reference structure (2003)

We describe a reference structure based sensor system for tracking the motion of an object. The reference structure is designed to implement a Hadamard transformation over a range of angular perspectives. We implemented a reference structure with an angular resolution of 5(o) and a field of view of 40(o).
Endoscopic scoring indices for evaluation of disease activity in ulcerative colitis (2015)

This is a protocol for a Cochrane Review (Methodology). The objectives are as follows: The primary objective is to systematically review the current literature describing the development and operating characteristics of endoscopic disease activity indices used to evaluate disease activity in UC.
Two schedules of teniposide with or without cisplatin in advanced non-small-cell lung cancer: a randomized study of the European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group. (1996)

The addition of cisplatin to VM26 improves the response rate, progression-free survival interval, and survival duration over VM26 alone, although at the cost of a significant increase in toxicity. Cisplatin should be considered as the basis for combination chemotherapies in advanced NSCLC.
Search for resonances in the mass distribution of jet pairs with one or two jets identified as b-jets in proton–proton collisions at s=13 TeV with the ATLAS detector (2016)

Searches for high-mass resonances in the dijet invariant mass spectrum with one or two jets identified as b -jets are performed using an integrated luminosity of 3.2 fb$^{−1}$ of proton–proton collisions with a centre-of-mass energy of $\sqrt{s}=13$ TeV recorded by the ATLAS detector at the Large Hadron Collider. No evidence of anomalous phenomena is observed in the data, which are used to exclude, at 95% credibility level, excited b⁎ quarks with masses from 1.1 TeV to 2.1 TeV and leptophobic Z′ bosons with masses from 1.1 TeV to 1.5 TeV. Contributions of a Gaussian signal shape with effective cross sections ranging from approximately 0.4 to 0.001 pb are also excluded in the mass range 1.5–5.0 TeV.
New results in the analysis of decision-feedback equalizers (2013)

This paper considers the decision feedback equalizers (DFE) with finite impulse response (FIR). Although they have been the subject of a number of studies, several longstanding problems in the analysis of these equalizers remained open. For the most part, the problems addressed in this paper are in the domain of high-SNR analysis, including the Diversity-Multiplexing Tradeoff (DMT) for DFE. We find that the DFE fixed-rate diversity follows the DMT analysis, unlike several examples from linear equalization in the recent literature where the fixed-rate diversity departed from the DMT expression. As part of the developments of this paper, the notion of the spectral representation of random processes is used to put the analysis of the decision feedback equalizers on a solid mathematical foundation.
Transparent Edge Gateway for Mobile Networks (2018)

Advances in software-defined networking (SDN) enable a wave of innovation in a wide selection of networks ranging from data center networks to WAN. While existing standard bodies for mobile networks define stringent requirements, they too are embracing the flexibility of SDN in defining the specifications of the next generation of mobile networks. Mobile edge computing (MEC), in particular, is an emerging architecture to bring virtualized network functions and programmable network devices closer to the user. For instance, delay-sensitive or bandwidth-hungry computing resources are moved to the edge of the radio access network (RAN) to provide low latency computation and/or content for users while alleviating the backhaul pressure for network operators. In this paper, we propose an edge gateway (EGW) in the MEC that enables offloading of computation and storage resources to the edge of mobile networks. The EGW is backward compatible with components and protocols of LTE networks and does not require any modification in the user equipment, LTE software, or offloaded resources. We have designed and implemented the EGW using P4 language and verified its operation on a small testbed using a low-end P4 target and a reference LTE protocol stack.
Different Routes for Preparing Mesoporous Organosilicas Containing the Tröger’s Base and Their Textural and Catalytic Implications (2011)

Organosilica materials with different contents of Tröger’s base (TB) as builder moieties have been synthesized from previously synthesized bis-trialkoxysilylated Tröger’s base. Three well-nanostructured hybrid mesoporous materials were prepared through different approachs: (a) anchoring the TB on a preformed silica SBA-15 material by postsynthesis grafting, (b) incorporating the TB fragments into the rigid and ordered periodic mesoporous organosilica (PMO) with hexagonal structure (HMS) by self-assembling process, and (c) using anion fluoride as catalyst for a sol−gel synthesis process in the absence of structural directing agents (SDAs), at neutral pH and low synthesis temperature, to introduce the TB units into the walls of high surface orderless mesoporous materials with flexible structure. The degree of long-range ordering of the materials was determined from X-ray diffraction and transmission electron microscopy and the texture of the various samples were analyzed by nitrogen sorption volumetry. The composition of the materials was determined by elemental analyses and thermogravimetry, and the integrity, topology and structuration level of the Tröger̀s base units were characterized by 13C NMR and 29Si MAS NMR spectroscopy. The materials were used as basic organocatalysts in Knoevenagel reaction. The disordered mesoporous hybrid materials show the highest catalytic activity due to the appropriate combination of high accessibility and structural flexibility. These mesoporous organosilica materials are stable upon recycling.
Light-Activated Sealing of Nerve Graft Coaptation Sites Improves Outcome following Large Gap Peripheral Nerve Injury (2015)

Light-activated sealing of cross-linked human amnion results in superior outcomes when compared with conventional suture.
Preparation of Size-Controlled Hat-Stacked Carbon Nanofibers (2007)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Y. Sato, A. Yokoyama, K. Motomiya, B. Jeyadevan, K. Tohji; Preparation of Size‐Controlled Hat‐Stacked Carbon Nanofibers. AIP Conf. Proc. 20 March 2007; 898 (1): 186–189. https://doi.org/10.1063/1.2721277 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
A reduced-order thermomechanical model and analytical solution for uniaxial shape memory alloy wire actuators (2009)

A lumped shape memory alloy (SMA) model is derived from the thermodynamic model of Chang et al (2006 Contin. Mech. Thermodyn. 18 83 118), using a set of simplifying assumptions, that reduces the system of partial differential equations for an SMA/bias spring actuator to a nonlinear, first-order, ordinary differential equation. Dimensionless state variables and parameters are defined that are useful for characterizing the actuator system and for studying its performance and scaling. A general analytical solution to the nonlinear differential equation governing phase transformation is found in terms of the Lambert function for a piecewise constant Joule heating input and a constant temperature convective environment. The analytical solution provides a useful and convenient tool for assessing the time-dependent, hysteretic response of this simple class of SMA actuators, with which design and optimization studies are performed.
Passive cavitation mapping for localization and tracking of bubble dynamics (2010)

Current acoustic techniques for studying cavitation dynamics are only readily applicable to single-bubble activity, while optical methods can only be used in transparent media. However, multi-bubble cavitation often occurs in opaque media such as biological tissue. Here, the signals received passively by each of the 64 channels of a diagnostic ultrasound array are used to localize and separate emissions from several bubble clusters cavitating in agar gel, thereby providing a method of observing cavitation dynamics. The method has a high spatiotemporal resolution and is applicable to cavitation in opaque media.
Formation and Structure of Work Material in the Friction Stir Forming Process (2015)

Friction stir forming (FSF) is a new environmentally friendly manufacturing process for lap joining of dissimilar materials. Fundamentally, this process is based on frictionally heating and mechanically stirring work material of the top piece in a plasticized state to form a mechanical interlocking joint within the bottom material. In this research, the significant process parameters were identified and optimized for Al 6014 alloy and mild steel using a design of experiments (DOE) methodology. The overall joint structure and grain microstructure were mapped as the FSF process progressed and the aluminum work material deformed through different stages. It was found that the work material within the joint exhibited two layers, thermomechanical affected zone, which formed due to the contact pressure and angular momentum of the tool, and heat affected formation zone, which was composed of work material formed through the hole in the steel sheet and into the anvil cavity. Two different geometries of anvil design were employed to investigate geometrical effects during FSF of the aluminum. It was found that the direction and amount of work material deformation under the tool varies from the center to the shoulder.
Innovation in Cell Banking, Expansion, and Production Culture (2018)

Cell culture-based production processes enable the development and commercial supply of recombinant protein products. Such processes consist of the following elements: thaw and initiation of culture, seed expansion, and production culture. A robust cell source storage system in the form of a cell bank is developed and cells are thawed to initiate the cell culture process. Seed culture expansion generates sufficient cell mass to initiate the production culture. The production culture provides an environment where the cells can synthesize the product and is optimized to deliver the highest possible product concentration with acceptable product quality. This chapter describes the significant innovations made in these process elements and the resulting improvements in the overall efficiency, robustness, and safety of the processes and products.
Electron-Microscope Observation of the Smectic-Nematic Transition in a Lyotropic Liquid Crystal (1986)

We observe via freeze-fracture transmission electron microscopy the transition from the disklike micellar nematic phase to the lamellar smectic phase of decylammonium chloride-ammonium chloridewater as a function of temperature. We show direct visual evidence of the size and shape of the aggregates in the nematic phase, the mechanism of the nematic-smectic transition, and the origin of the residual in-plane order in the smectic phase. These observations are consistent with previous scattering, conductivity, and NMR measurements on this system.
Plasma FLT3‐L levels predict bone marrow recovery from myelosuppressive therapy (2000)

BACKGROUND During the recovery period after anticancer myelosuppressive therapy, hematopoietic progenitor cells become mitotically active in order to replenish the bone marrow compartment and remain hyperproliferative even after normalization of peripheral white blood cells and platelets. At this stage, the progenitors are more radiosensitive and chemosensitive. Dosing patients with additional cytotoxic therapy during this phase will likely result in more severe toxicity. For example, the authors have noted that the red bone marrow (RM) dose resulting from radioantibody therapy does not correlate with observed bone marrow toxicity. Several patients given similar RM doses had Grade 3 or 4 toxicity, whereas others had Grade 0–2 toxicity even though their white blood cell (WBC) and (PLT) counts were normal at the time of dosing. The goal of these studies was to establish a noninvasive predictive marker of bone marrow activity that could determine stem cell and progenitor cell recovery from previous myelosuppressive therapy. METHODS A retrospective study was conducted to quantitate plasma levels of 5 cytokines regulating hematopoiesis, namely, 2 stimulatory fms-like tyrosine kinase (FLT3-L) and stem cell factor (SCF) and 3 inhibitory growth factors tumor necrosis factor-α (TNFα), tumor growth factor-β, and macrophage inflammatory protein (MIP-1α), by immunoassay in 43 patients enrolled in clinical trials at Garden State Cancer Center in Belleville, New Jersey. All patients had had previous chemotherapy with a duration of 1–24 months. The serum cytokine values were correlated with the magnitude of leukopenia or thrombocytopenia following a single dose of radioantibody as the cytotoxic therapy. RESULTS Plasma FLT3-L levels predicted excess platelet toxicity in 13 of 16 patients (mean = 225 ± 106 pg/mL) and resulted in a false-positive in only 3 of 27 other patients (mean = 80 ± 41 pg/mL). Plasma FLT3-L > 135 pg/mL resulted in 81% sensitivity and 89% and 86% specificity and accuracy, respectively, for predicting excess toxicity caused by additional cytotoxic therapy. The positive likelihood ratio was 7.5 (95% confidence interval, 2.5–22.5) and the negative likelihood ratio was 0.19 (95% confidence interval, 0.05–0.67). CONCLUSIONS Elevated plasma FLT3-L in patients who previously received chemotherapy is a predictive measure of the stage of recovery of the bone marrow compartment. FLT3-L seems to identify the likelihood that the patient will experience Grade ≥ 3 thrombocytopenia if additional cytotoxic therapy is administered. Knowledge of bone marrow activity should permit therapy that is more aggressive by establishing the earliest possible time for dosing with any cytotoxic agent for which myelosuppression is the dose-limiting toxicity. Cancer 2000;88:333–43. © 2000 American Cancer Society.
Study on bilayer yttria stabilized zirconia / gadolinia doped ceria deposits manufactured by reactive magnetron sputtering (2017)

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