gebhart/patrepeval huggingface dataset:
Hybrid Th1/17 cells possess unique immuno-metabolic phenotype and surpiror anti-tumor activity (2016)

Abstract Immunotherapy of cancer is a promising approach for successful eradication of large and established tumor. Accumulating evidence indicates that CD4+ T helper (Th) cells including Th1 and Th17 subsets are also effective in tumor immunotherapy. While the anti-tumor potential of Th17 cells primarily depends upon IFN-γ secretion and persistence, a long-term tumor control has still remained elusive. In current study, we established an optimal protocol to program CD4 T cells ex vivo into a combinational phenotype of Th1 and Th17 subset (named hybrid Th1/17 cells), which express high levels of IFN-γ, CD107a, T-bet, Granzyme B, IL23R, IL22, Bcl6, and Tcf7. A detailed microaray analysis followed by Ingenutity Pathway Analysis for hybrid Th1/17 cells further established its unique molecular signature. Importantly, a comprehensive analysis for about 400 metabolites also established that hybrid Th1/17 cells have unique metaboliomic signature. Furthermore, using two types of TCR transgenic models and established B16 tumor model either administrated subcutaneously or intravenously, we demonstrated that the hybrid Th1/17 cells exhibit a superior activity in controlling tumor as compared to Th1 or Th17 alone. We observed that the unique immuno-metabolic phenotype rendered to hybrid Th1/17 cells corrected with their increased ability to survive, overcome tumor mediated immunosuppression, resulting the superior effectiveness to control tumor in long-term.
Optical spectroscopy of copper cation/silver cation doped .beta.''-alumina (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptical spectroscopy of copper cation/silver cation doped .beta.''-aluminaKyeong Sook Kim Shin, James D. Barrie, Bruce Dunn, and Jeffrey I. ZinkCite this: J. Am. Chem. Soc. 1990, 112, 15, 5701–5706Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/ja00171a004https://doi.org/10.1021/ja00171a004research-articleACS PublicationsRequest reuse permissionsArticle Views168Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel Automated Blood Separations Validate Whole Cell Biomarkers (2011)

Improving, automating and standardizing lymphocyte detections from whole blood may facilitate development of new cell-based biomarkers for human diseases. Improved upfront blood processes may lead to broad improvements in monitoring early trial outcome measurements in human clinical trials.
Fuel economy and performance improvement enabled by medium-duty dual clutch transmissions (2015)

In the past decade dual clutch transmissions (DCTs) have gained significant market share over torque converter automatic (TCA) transmissions in the passenger car sector, partially due to fuel economy improvement. Although today's North American medium-duty (MD) truck market is predominantly TCA technology, DCT technology has the potential to improve MD truck fuel economy and performance. This paper includes detailed comparisons of the key technology hardware and controls differences, their influence on driveline efficiency, and vehicle application optimisation. The losses of a DCT and a TCA were characterised over their relevant operating ranges and then incorporated into MATLAB®/Simulink® models. The models were validated with chassis dynamometer data and are capable of quantifying the trade-off between vehicle performance requirements and fuel economy. The analysis concludes with results from the fuel economy studies as well as observations of other performance benefits of the DCT technology in the MD market space.
Préparation et évaluation de substrats d'InP adaptés à différents types d'épitaxie (1997)

L'objectif de cette these etait de mettre au point pour la societe inpact, une filiere technologique de preparation de substrats d'inp pret a l'emploi adaptee a tous les types d'epitaxie et notamment l'epitaxie par jets moleculaires (ejm) et l'epitaxie en phase vapeur aux organometalliques (epvom). La preparation consiste, en partant d'une surface propre, a oxyder l'inp pour fabriquer une couche protectrice pouvant se sublimer dans le reacteur avant l'epitaxie. L'optimisation de la preparation de la surface a consiste d'une part a reduire les defauts en surface du substrat, en controlant les parametres de la gravure chimique au brome methanol et les operations de rincage et de sechage de plaquettes. Nous avons montre que l'encapsulation par un oxyde uv/o#3 convenait a un procede industriel. Nous avons determine qu'une epaisseur d'oxyde de 4-5 a etait optimale car la reaction de desorption de l'oxyde etait gouvernee par le phosphore issu de la dissociation de l'inp. En epvom, l'augmentation de l'epaisseur d'oxyde degrade les proprietes de l'interface substrat/couche epitaxiee. Nous avons etabli que l'accumulation de porteurs de type n a l'interface avec les substrats semi-isolants, provenait de la contamination de la surface par le silicium. L'etude du vieillissement des oxydes a l'air et sous azote a revele qu'il etait necessaire de stocker le substrat sous azote avec un oxyde de 4-5 a mais qu'une epaisseur d'oxyde de 7-8 a pouvait mieux supporter un emploi du substrat sur plusieurs jours. Dans les conditions ou le substrat est stocke sous azote, la meilleure alternative a l'oxyde uv/o#3 est un oxyde chimique. Alors que pour l'ejm les mecanismes de la croissance sont aujourd'hui relativement bien connus, l'etude de l'homoepitaxie d'inp en epvom nous a permis de mieux cerner, en fonction des conditions de temperature et de la desorientation du substrat, les differents modes de croissance en epvom : croissance par avancee de marches (step flow) et regroupement des marches (step bunching). Nous avons pu montre que les dislocations vis du substrat etaient a l'origine des defauts structuraux appeles volcan. Nous avons demontre que pour limiter ces defauts, il fallait desorienter legerement le substrat (0,1-0,2). Dans ce cas, la gamme des conditions de croissance pour l'obtention de couches sans defaut etait elargie.
Evaluation of 111In-DOTA-5D3, a Surrogate SPECT Imaging Agent for Radioimmunotherapy of Prostate-Specific Membrane Antigen (2018)

5D3 is a new high-affinity murine monoclonal antibody specific for prostate-specific membrane antigen (PSMA). PSMA is a target for the imaging and therapy of prostate cancer. <sup>111</sup>In-labeled antibodies have been used as surrogates for <sup>177</sup>Lu/<sup>90</sup>Y-labeled therapeutics. We characterized <sup>111</sup>In-DOTA-5D3 by SPECT/CT imaging, tissue biodistribution studies, and dosimetry. <b>Methods:</b> Radiolabeling, stability, cell uptake, and internalization of <sup>111</sup>In-DOTA-5D3 were performed by established techniques. Biodistribution and SPECT imaging were done on male nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice bearing human PSMA(+) PC3 PIP and PSMA(-) PC3 flu prostate cancer xenografts on the upper right and left flanks, respectively, at 2, 24, 48, 72, and 192 h after injection. Biodistribution was also evaluated in tumor-free, healthy male CD-1 mice. Blocking studies were performed by coinjection of a 10-fold and 50-fold excess of 5D3 followed by biodistribution at 24 h to determine PSMA binding specificity. The absorbed radiation doses were calculated on the basis of murine biodistribution data, which were translated to a human adult man using organ weights as implemented in OLINDA/EXM. <b>Results:</b><sup>111</sup>In-DOTA-5D3 was synthesized with specific activity of approximately 2.24 ± 0.74 MBq/μg (60.54 ± 20 μCi/μg). Distribution of <sup>111</sup>In-DOTA-5D3 in PSMA(+) PC3 PIP tumor peaked at 24 h after injection and remained high until 72 h. Uptake in normal tissues, including the blood, spleen, liver, heart, and lungs, was highest at 2 h after injection. Coinjection of <sup>111</sup>In-DOTA-5D3 with a 10- and 50-fold excess of nonradiolabeled antibody significantly reduced PSMA(+) PC3 PIP tumor and salivary gland uptake at 24 h but did not reduce uptake in kidneys and lacrimal glands. Significant clearance of <sup>111</sup>In-DOTA-5D3 from all organs occurred at 192 h. The highest radiation dose was received by the liver (0.5 mGy/MBq), followed by the spleen and kidneys. Absorbed radiation doses to the salivary and lacrimal glands and bone marrow were low. <b>Conclusion:</b><sup>111</sup>In-DOTA-5D3 is a new radiolabeled antibody for imaging and a surrogate for therapy of malignant tissues expressing PSMA.
Constant-Envelope Multi-User Precoding for Frequency-Selective Massive\n MIMO Systems (2013)

We consider downlink precoding in a frequency-selective multi-user Massive\nMIMO system with highly efficient but non-linear power amplifiers at the base\nstation (BS). A low-complexity precoding algorithm is proposed, which generates\nconstant-envelope (CE) signals at each BS antenna. To achieve a desired\nper-user information rate, the extra total transmit power required under the\nper-antenna CE constraint when compared to the commonly used less stringent\ntotal average transmit power constraint, is small.\n
Large scale solar power plant in Nordic conditions (2014)

Solar power plants have become common during last few years in the middle Europe, especially in Germany. On the other hand, solar power has not grown in the Nordic countries, in spite of Denmark after the favorable net-metering legislation in the year 2011. Finland is one of these countries that has low solar power capacity. Many Nordic countries, such as Finland, have relatively low electricity price that is supposed to cause challenges for the viability of solar power production without legislation or does it? In this paper, the potential for solar power production in Nordic conditions is studied, simulated, and measured. A large scale solar power plant is built to Lappeenranta University of Technology (LUT).
PICO: Probe of Inflation and Cosmic Origins (2019)

The Probe of Inflation and Cosmic Origins (PICO) is an imaging polarimeter that will scan the sky for 5 years in 21 frequency bands spread between 21 and 799 GHz. It will produce full-sky surveys of intensity and polarization with a final combined-map noise level of 0.87 $μ$K arcmin for the required specifications, equivalent to 3300 Planck missions, and with our current best-estimate would have a noise level of 0.61 $μ$K arcmin (6400 Planck missions). PICO will either determine the energy scale of inflation by detecting the tensor to scalar ratio at a level $r=5\times 10^{-4}~(5σ)$, or will rule out with more than $5σ$ all inflation models for which the characteristic scale in the potential is the Planck scale. With LSST's data it could rule out all models of slow-roll inflation. PICO will detect the sum of neutrino masses at $&gt;4σ$, constrain the effective number of light particle species with $ΔN_{\rm eff}&lt;0.06~(2σ)$, and elucidate processes affecting the evolution of cosmic structures by measuring the optical depth to reionization with errors limited by cosmic variance and by constraining the evolution of the amplitude of linear fluctuations $σ_{8}(z)$ with sub-percent accuracy. Cross-correlating PICO's map of the thermal Sunyaev-Zeldovich effect with LSST's gold sample of galaxies will precisely trace the evolution of thermal pressure with $z$. PICO's maps of the Milky Way will be used to determine the make up of galactic dust and the role of magnetic fields in star formation efficiency. With 21 full sky legacy maps in intensity and polarization, which cannot be obtained in any other way, the mission will enrich many areas of astrophysics. PICO is the only single-platform instrument with the combination of sensitivity, angular resolution, frequency bands, and control of systematic effects that can deliver this compelling, timely, and broad science.
ChemInform Abstract: Stereospecific Synthesis of the Enantiomers of Nicotinylalanine, a Neuroprotecting Agent. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hardware Modifications to the US Army Research Laboratory's Metalorganic Chemical Vapor Deposition (MOCVD) System for Optimization of Complex Oxide Thin Film Fabrication (2015)

Abstract : An introduction to various metalorganic chemical vapor deposition (MOCVD) reactor designs and precursor delivery methods for the growth of complex oxide thin films is presented with comments on the respective advantages and limitations of each variation. Hardware modifications were made to the US Army Research Laboratory s MOCVD system in attempts to improve film purity and quality. A loading chamber was installed with a wobblestick load arm to protect samples from impurities in the main MOCVD chamber prior to deposition. Camera and light sources to provide a live video feed of the main MOCVD chamber were also installed to assist with the transportation of samples from the load chamber to the sample heater. Strontium titanate thin films were grown on platinized silicon substrates and were characterized by X-ray diffraction, scanning electron microscopy, and atomic force microscopy to investigate the impact of the implemented hardware modifications on composition, film quality, and homogeneity.
Filtered Historical SimulationValue at Risk for Options : A Dimension Reduction Approach to Model the VolatilitySurface Shifts (2019)

Filtered Historical SimulationValue at Risk for Options : A Dimension Reduction Approach to Model the VolatilitySurface Shifts
A Transmission-Line-Based Decoupling Method for MIMO Antenna Arrays (2019)

A transmission-line-based decoupling technique for dual-polarized multiple-input and multiple-output (MIMO) antenna arrays is presented and analyzed. The proposed scheme enables well-canceled coupling for the adjacent elements under co-polarization, without degrading the isolation of the cross-polarized ports. First, a decoupling network based on the presented method for a 2 × 2 MIMO array is provided, along with a comprehensive design procedure. Calculations and simulations are operated to verify decoupling performance. For further verification, a 2 × 2 dual-polarized patch array with the proposed decoupling method is developed. The decoupling network characterizes low profile, compact size, and low insertion loss, which is realized in a single layer. Measurements denote that the isolations between the co-polarized elements are improved from 16 to 20 dB to over 30 dB after decoupling at the center frequency of 2.45 GHz. Subsequently, based on the proposed 2 × 2 decoupling method, a decoupling network for large-scale dual-polarized MIMO arrays is presented. A design example of a 4 × 4 dual-polarized patch antenna array is established. Fullwave simulations indicate that the isolations are enhanced to better than 30 dB with a small insertion loss of less than 0.45 dB and can widely be used for phased array and massive MIMO array systems.
Neuroethics Guiding Principles for the NIH BRAIN Initiative (2018)

Neuroscience presents important neuroethical considerations. Human neuroscience demands focused application of the core research ethics guidelines set out in documents such as the Belmont Report. Various mechanisms, including institutional review boards (IRBs), privacy rules, and the Food and Drug
Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis (2016)

The American Thoracic Society, Centers for Disease Control and Prevention, and Infectious Diseases Society of America jointly sponsored the development of this guideline for the treatment of drug-susceptible tuberculosis, which is also endorsed by the European Respiratory Society and the US National Tuberculosis Controllers Association. Representatives from the American Academy of Pediatrics, the Canadian Thoracic Society, the International Union Against Tuberculosis and Lung Disease, and the World Health Organization also participated in the development of the guideline. This guideline provides recommendations on the clinical and public health management of tuberculosis in children and adults in settings in which mycobacterial cultures, molecular and phenotypic drug susceptibility tests, and radiographic studies, among other diagnostic tools, are available on a routine basis. For all recommendations, literature reviews were performed, followed by discussion by an expert committee according to the Grading of Recommendations, Assessment, Development and Evaluation methodology. Given the public health implications of prompt diagnosis and effective management of tuberculosis, empiric multidrug treatment is initiated in almost all situations in which active tuberculosis is suspected. Additional characteristics such as presence of comorbidities, severity of disease, and response to treatment influence management decisions. Specific recommendations on the use of case management strategies (including directly observed therapy), regimen and dosing selection in adults and children (daily vs intermittent), treatment of tuberculosis in the presence of HIV infection (duration of tuberculosis treatment and timing of initiation of antiretroviral therapy), as well as treatment of extrapulmonary disease (central nervous system, pericardial among other sites) are provided. The development of more potent and better-tolerated drug regimens, optimization of drug exposure for the component drugs, optimal management of tuberculosis in special populations, identification of accurate biomarkers of treatment effect, and the assessment of new strategies for implementing regimens in the field remain key priority areas for research. See the full-text online version of the document for detailed discussion of the management of tuberculosis and recommendations for practice.
Towards a closed-loop system for stimulation and recording: An in vitro approach with embryonic cardiomyocytes (2010)

Closed loop systems, in which stimulation parameters are adjusted according to recorded signals would reduce the occurrence of side effects of stimulation and broaden current therapeutic options. As a step towards a closed-loop clinical system, we developed a single electrode stimulation / recording system for an in vitro microelectrode array. The system was used in vitro to simultaneously stimulate and record cardiac cells. Results indicated that stimulation artifacts depend on the distance between recording electrode and stimulating electrode and on the voltage amplitude. No artifact reduction algorithm was required for detecting cardiac action potentials 2ms after stimulation if the stimulation pulses were less than or equal to ± 1.5 V, and the distance from stimulation site was more than 200 µm. Cardiac signal propagation was also investigated with this system.
Setting HUMS condition indicator thresholds by modeling aircraft and torque band variance (2004)

Health and usage management systems (HUMS) compute a number of condition indicators (CIs) from physical measurements, such as vibration. These CIs are used to characterize the health of the component. When the CI exceeds some threshold, the component is deemed to be in warning (perform additional analysis) or alarm (component is faulted and requires maintenance). This work presents an approach for the robust configuration of thresholds to control false alarm while maintaining reliable detection. Results are presented for this methodology applied to the CIs monitoring a typical helicopter drive train.
Two-factor Password-authenticated Key Exchange with End-to-end Security (2021)

We present a secure two-factor authentication (TFA) scheme based on the user’s possession of a password and a crypto-capable device. Security is “end-to-end” in the sense that the attacker can attack all parts of the system, including all communication links and any subset of parties (servers, devices, client terminals), can learn users’ passwords, and perform active and passive attacks, online and offline. In all cases the scheme provides the highest attainable security bounds given the set of compromised components. Our solution builds a TFA scheme using any Device-enhanced Password-authenticated Key Exchange (PAKE), defined by Jarecki et al., and any Short Authenticated String (SAS) Message Authentication, defined by Vaudenay. We show an efficient instantiation of this modular construction, which utilizes any password-based client-server authentication method, with or without reliance on public-key infrastructure. The security of the proposed scheme is proven in a formal model that we formulate as an extension of the traditional PAKE model. We also report on a prototype implementation of our schemes, including TLS-based and PKI-free variants, as well as several instantiations of the SAS mechanism, all demonstrating the practicality of our approach. Finally, we present a usability study evaluating the viability of our protocol contrasted with the traditional PIN-based TFA approach in terms of efficiency, potential for errors, user experience, and security perception of the underlying manual process. 1