gebhart/patrepeval huggingface dataset:
Communicating the sum of sources over a network (2008)

We consider a network (that is capable of network coding) with a set of sources and terminals, where each terminal is interested in recovering the sum of the sources. Considering directed acyclic graphs with unit capacity edges and independent, unit-entropy sources, we show the rate region when (a) there are two sources and n terminals, and (b) n sources and two terminals. In these cases as long as there exists at least one path from each source to each terminal we demonstrate that there exists a valid assignment of coding vectors to the edges such that the terminals can recover the sum of the sources.
Distinct Cross-reactive B-Cell Responses to Live Attenuated and Inactivated Influenza Vaccines (2014)

Distinct quantitative and qualitative patterns of plasmablast responses were induced by LAIV and IIV in young adults; a proportionally greater cross-reactive response was induced by LAIV.
Beyond NMF: Advanced Signal Processing and Machine Learning Methodologies for Hyperspectral Analysis in EELS (2021)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the 'Save PDF' action button.
Controlled Growth of Heterostructured Ga/GaAs Nanowires with Sharp Schottky Barrier (2018)

Because of the inevitable Fermi level pinning on surface/interface states of nanowires, achieving high-performance nanowire devices with controllable nanoscale contacts is always challenging but important. Herein, single-crystalline heterostructured Ga/GaAs nanowires with sharp hetero-Schottky interfaces have been successfully synthesized on amorphous substrates by utilizing Au nanoparticles as catalytic seeds via chemical vapor deposition. These nanowires are found to grow with the hemispherical Au7Ga2 catalytic tips following the vapor–liquid–solid mechanism. During the growth, simply by manipulating the source and growth temperatures, the Ga precipitation rate from Au–Ga alloy tips as well as the reaction rate of Ga precipitates with As can be reliably controlled in order to tailor the length (0–170 nm) of Ga nanowire segments obtained in the heterostructure. When configured into field-effect transistors, these Ga/GaAs NWs exhibit the p-type conductivity with a sharp hetero-Schottky barrier of ∼1.0 eV at the atomically connected Ga segment/GaAs NW body interface, in which this barrier height is close to the theoretical difference between the GaAs Fermi level (5.1–5.3 eV) and the Ga work function (∼4.3 eV), suggesting the effective formation of nanoscale contact by minimizing the Fermi level pinning, being advantageous for advanced nanoelectronics.
A Wyner-Ziv Video Transcoder (2009)

Wyner-Ziv (WZ) coding of video utilizes simple encoders and highly complex decoders. A transcoder from a WZ codec to a traditional codec can potentially increase the range of applications for WZ codecs. We present a transcoder scheme from the most popular WZ codec architecture to a differential pulse code modulation/discrete cosine transform codec. As a proof of concept, we implemented this transcoder using a simple pixel-domain WZ codec and the standard H.263+. The transcoder design aims at reducing complexity as a large amount of computation is saved by reusing the motion estimation, calculated at the side information generation process, and the l-frame streams. New approaches are used to generate side information and to map motion vectors for the transcoder. Results are presented to demonstrate the transcoder performance.
The effect of raloxifene on coronary arteries in aged ovariectomized ewes (2000)

The results indicate that raloxifene in this sheep model allows greater dilation of coronary arteries than estrogen. Raloxifene may provide a significant protective functional effect on coronary arteries in postmenopausal heart disease.
Peptide Mapping by Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis (1996)

The comparison of the primary structure of proteins is an important facet in the characterization of families of proteins from the same organism, similar proteins from different organisms, and cloned gene products. There are many methods available to establish the sequence similarities of proteins. A relatively uncomplicated approach is to compare the peptide fragments of proteins generated by enzymatic or chemical cleavage, i.e., peptide mapping. The similarity or dissimilarity of the resultant peptides reflects the similarity or dissimilarity of the parent proteins.
Photovoltaic Properties of Dye Functionalized Single-Wall Carbon Nanotube/Conjugated Polymer Devices (2004)

Photovoltaic properties of dye, N-(1-pyrenyl)maleimide (PM), functionalized single-walled carbon nanotubes (SWNT)−conjugated polymer, poly(3-octylthiophene) (P3OT), blend composites are reported. Devices were fabricated by drop or spin cast from the solution of composite onto ITO-coated glass. Improved performance was achieved by functionalizing the SWNT with dye molecules. Photovoltaic behavior with an open circuit voltage of 0.6−0.7 V was measured in diodes (Al/SWNT+PM−polymer/ITO). The short circuit current was found to increase by more than an order of magnitude compared to the SWNT−polymer diode without dye. Optical absorption spectra showed considerable ground-state interaction between SWNT+dye and the polymer. It is proposed that the main reason for the increase in short circuit current is due to efficient transfer of holes by dye molecules to P3OT at the dye/polymer interface and the rapid transfer of the generated electrons to the SWNTs at the dye/nanotube interface. It is shown that the dye functionalized SWNT−conjugated polymer composites represent an alternative class of organic semiconducting materials for dye-based organic photovoltaic cells.
Equation of State of a Complex Fluid Column and Prediction of Contacts in Orocual Field, Venezuela (2000)

Abstract Diligent management of a high-pressure gas injection program in a field with a complex column of hydrocarbon fluids requires reservoir modeling. It is important and necessary to perform a detailed study of the PVT samples including the evaluation of the fluid distributions and to define an equation-of-state (EOS) to be used in a reservoir model. The Orocual field is located in the northern Monagas state of Venezuela and is owned and operated by Petroleos de Venezuela, S.A. (PDVSA), the national oil company of Venezuela. The field is characterized as a complex structure having more than 3000 feet of vertical hydrocarbon column. Fluids change from light gas in the top of the structure to condensate gas, to a near-critical transition fluid and volatile oil, to under-saturated oil at the bottom of the column. Reservoir compartmentalization adds complexity to the field and structurally equivalent, non-communicating fluid regions exist. The dispersion of some sample characteristics versus depth was thought to be the result of non-representative samples. The ability to integrate the PVT data into the geological model adds another dimension in defining the structural complexities. The paper demonstrates a technique to identify representative samples for use in developing an EOS, and for initializing fluids in place. A method is presented to adjust the component composition versus depth, providing consistent vertical composition distribution and compositional model stability. This method meets the objectives of matching field production observations. Also, a method is presented to quickly initialize a full field model using a 1-D compositional simulator to give full field model stability in an environment of high temperature gradient. The final result is a 7 pseudo-component EOS with a single characterization defining the compositional gradient of the hydrocarbon column from gas to black oil. The method demonstrates that composition relative to depth can be predicted in those parts of the reservoir where samples do not exist, but where production and test data must be matched. Other areas in northern Monagas state have similarly complex systems1. Many areas are only partially developed and can benefit by applying techniques presented in this paper to describe the fluids and to estimate gas-oil contacts. Results of compositional simulation show a single EOS and vertical compositional variation reproduce the complex character of the field hydrocarbon column, matching field measured observations of saturation pressure (ps), gas-oil-ratio (GOR) and fluid densities.
Solvation Structure and Dynamics of Mg(TFSI)2 Aqueous Electrolyte (2021)

Using ab initio molecular dynamics (AIMD) simulations, classical molecular dynamics (CMD) simulations, small‐angle X‐ray scattering (SAXS), and pulsed‐field gradient nuclear magnetic resonance (PFG‐NMR), the solvation structure and ion dynamics of magnesium bis(trifluoromethanesulfonyl)imide (Mg(TFSI) 2 ) aqueous electrolyte at 1, 2, and 3 m concentrations are investigated. From AIMD and CMD simulations, the first solvation shell of an Mg 2+ ion is found to be composed of six water molecules in an octahedral configuration and the solvation shell is rather rigid. The TFSI − ions prefer to stay in the second solvation shell and beyond. Meanwhile, the comparable diffusion coefficients of positive and negative ions in Mg(TFSI) 2 aqueous electrolytes have been observed, which is mainly due to the formation of the stable [Mg(H 2 O) 6 ] 2+ complex, and, as a result, the increased effective Mg ion size. Finally, the calculated correlated transference numbers are lower than the uncorrelated ones even at the low concentration of 2 and 3 m, suggesting the enhanced correlations between ions in the multivalent electrolytes. This work provides a molecular‐level understanding of how the solvation structure and multivalency of the ion affect the dynamics and transport properties of the multivalent electrolyte, providing insight for rational designs of electrolytes for improved ion transport properties.
DeepFly3D: A deep learning-based approach for 3D limb and appendage tracking in tethered, adult Drosophila (2019)

Abstract Studying how neural circuits orchestrate limbed behaviors requires the precise measurement of the positions of each appendage in 3-dimensional (3D) space. Deep neural networks can estimate 2-dimensional (2D) pose in freely behaving and tethered animals. However, the unique challenges associated with transforming these 2D measurements into reliable and precise 3D poses have not been addressed for small animals including the fly, Drosophila melanogaster . Here we present DeepFly3D, a software that infers the 3D pose of tethered, adult Drosophila —or other animals—using multiple camera images. DeepFly3D does not require manual calibration, uses pictorial structures to automatically detect and correct pose estimation errors, and uses active learning to iteratively improve performance. We demonstrate more accurate unsupervised behavioral embedding using 3D joint angles rather than commonly used 2D pose data. Thus, DeepFly3D enables the automated acquisition of behavioral measurements at an unprecedented level of resolution for a variety of biological applications.
Isolation and comparative properties of shrimp trypsin (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation and comparative properties of shrimp trypsinB. J. Gates and J. TravisCite this: Biochemistry 1969, 8, 11, 4483–4489Publication Date (Print):November 1, 1969Publication History Published online1 May 2002Published inissue 1 November 1969https://pubs.acs.org/doi/10.1021/bi00839a039https://doi.org/10.1021/bi00839a039research-articleACS PublicationsRequest reuse permissionsArticle Views168Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High Temperature PTC Thermistor Using Ba Cobaltite (2002)

Abstract It was found that partially Fe-substituted Ba cobaltite, BaCo0.7Fe0.3O3-δ, shows sharp PTC behavior at temperature above 850 °C. As revealed by XRD measurements, the PTC behavior is accompanied by phase transformation between hexagonal perovskite structure (low temperature) and cubic one (high temperature).
Biceps Tenotomy Does not Affect the Functional Outcomes of Patients Treated with Spacer Implantation Due to Massive Irreparable Rotator Cuff Tears (2017)

Current study demonstrates that spacer implantation in this patient population provides significant improvement in function and decreases the pain. Additional LHB tenotomy did not influence the postoperative results during the follow-up.
Parametric Release (2018)

The term dosimetric release is often applied synonymously with process control release or parametric release. The Parenteral Drug Association (PDA) Task Force and Research Committee suggested that parametric release means the lot release of terminally sterilized product based on measured and documented information related to the operation and control of the sterilization process during routine manufacturing and sterilization of the product. The PDA concluded that the Food and Drug Administration (FDA) Compliance Policy Guide is a qualified statement that does not fully recognize parametric release. Since parametric release will depend on information obtained from measurements and the majority of the data generated critical to the success of the process, a comprehensive calibration program is essential for parametric release. Gaseous sterilization is considered by some practitioners to be inappropriate for parametric release; nevertheless, there seems to be a consensus that the number of variables to be controlled for Ethylene oxide processing does indeed present a challenge.
An optimised normalised LMF algorithm for sub-Gaussian noise (2004)

The least mean fourth (LMF) algorithm is known for its fast convergence and lower steady state error, especially under sub-Gaussian noise conditions. Meanwhile, the recent work on the normalised versions of LMF algorithm has further enhanced its stability and performance in both Gaussian and sub-Gaussian noise. For example, the normalised LMF (XE-NLMF) algorithm, recently developed, is normalised by the mixed signal power and error power, and weighted by a fixed mixed-power parameter. Unfortunately, this algorithm depends on the selection of this mixing parameter. To overcome this obstacle, in this work, a time-varying mixed-power parameter technique is introduced to optimise its selection. An enhancement in performance is obtained through the use of this procedure in both the convergence rate and steady-state error.
Mapping Meetings: Columbia's Plans (2001)

An introduction of Columbia University's participation in the NSF-funded Mapping Meetings project.
Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in Saccharomyces cerevisiae (2012)

The target of rapamycin (TOR) is a critical regulator of growth, survival, and energy metabolism. The allosteric TORC1 inhibitor rapamycin has been used extensively to elucidate the TOR related signal pathway but is limited by its inability to inhibit TORC2. We used an unbiased cell proliferation assay of a kinase inhibitor library to discover QL-IX-55 as a potent inhibitor of S. cerevisiae growth. The functional target of QL-IX-55 is the ATP-binding site of TOR2 as evidenced by the discovery of resistant alleles of TOR2 through rational design and unbiased selection strategies. QL-IX-55 is capable of potently inhibiting both TOR complex 1 and 2 (TORC1 and TORC2) as demonstrated by biochemical IP kinase assays (IC(50) <50 nM) and cellular assays for inhibition of substrate YPK1 phosphorylation. In contrast to rapamycin, QL-IX-55 is capable of inhibiting TORC2-dependent transcription, which suggests that this compound will be a powerful probe to dissect the Tor2/TORC2-related signaling pathway in yeast.
Speaker change detection and speaker diarization using spatial information (2015)

In this paper, we present a novel speaker change detection and speaker diarization algorithm using spatial information in the form of features derived from estimated Room Impulse Response (RIR)s. A blind system identification approach is used to obtain an estimate of the RIRs, from which the C5 feature is derived and used in the labeling algorithm. Experimental results using 2 speakers for different locations within a fixed room show that our approach achieves a higher hit rate in the speaker change detection task and a lower variance in the diarization error rate when compared with a baseline algorithm.
Isolation and Clonal Characterization of Hematopoietic and Liver Stem Cells (2004)

With the use of FACS and monoclonal antibodies, hematopoietic and liver stem cells were prospectively isolated and characterized. HSCs could also be purified by Hoechst 33342 staining. By expression cloning, we identify bcrp-1/ABCG2 transporter as a molecule responsible for SP phenotype. Elucidation of the physiological role of bcrp-1/ABCG2 in HSCs may provide us with clues to understand the molecular mechanisms of stem cell self-renewal and differentiation.
A Systematic Review and Meta-Analysis of treatment of infected Tibial non union (2021)

Objectives: The aim of this work is to systematically review and make metaanalysis for treatment of the infected non-union of the tibia.Methodology: A systematic review was completed, Study objective and comprehensive literature search were performed from the SCI, PubMed, Cochrane Library; and Embase between January 2000 and Feb. 2019. Some major data were statistically analyzed, including number of patients, mean age,external fixation time, Searches will be performed in the MEDLINE, Life Science Citations, PubMed, GoogleScholar and EMBASE Biochemical (http://www.embase.com) databases will be accessed to search studies with no limits set during research, Terms aimed at capturing the target diagnosis, such as “infected tibial nonunion” and “fixation” were combined using the Boolean operator “or” and MeSH terms.Result: 318 abstracts were identified during the search, 10 were excluded, 308 full articles were fully reviewed, 295 articles were excluded, 13 studied matched the inclusion criteria and were included in this review, 2 additional articles were identified during searching, a total 652 patients of 15 studies were presented in this systemic review. Conclusion: radical debridment of the infected non union is mandatory , a satisfactory bone results and functional results were obtained. On the other hand Ilizaov technique proved as the most useful method in the treatment of the infected non- union of the tibia.
The Glycosyltransferase Gene Encoding the Enzyme Catalyzing the First Step of Mycothiol Biosynthesis ( mshA ) (2003)

Mycothiol is the major thiol present in most actinomycetes and is produced from the pseudodisaccharide 1D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins). A transposon mutant of Mycobacterium smegmatis shown to be GlcNAc-Ins and mycothiol deficient was sequenced to identify a putative glycosyltransferase gene designated mshA. The ortholog in Mycobacterium tuberculosis, Rv0486, was used to complement the mutant phenotype.
Modelling and estimation of combustion variability for fast light-off of diesel aftertreatment (2020)

Combustion phasing retard is commonly used on diesel engines to achieve faster aftertreatment light-off and lower tailpipe emissions. Aggressive combustion phasing retard can achieve higher exhaust gas enthalpy at the cost of increased combustion variability, which can create vehicle noise, vibration, and harshness (NVH) issues. To avoid such issues while maximising exhaust heating, feedback from cylinder pressure sensors can be used to control the coefficient of variation of the indicated mean effective pressure (CoVIMEP) to a maximum allowable value. Therefore, a control-oriented combustion model that captures the stochastic properties of the cycle-to-cycle variability for IMEP has been developed for control design. Unbiased estimation methods for the CoVIMEP using finite impulse response (FIR) and infinite impulse response (IIR) filters are discussed. Finally, the performance of the estimation strategy is tested during an engine warm-up phase to show that it is a suitable alternative for generating a feedback signal for control.
Abstract 585: AB-1015, a novel integrated circuit T cells containing an ALPG/MSLN logic gate and FAS/PTPN2 shRNA-miR, demonstrates specific and potent activity against ALPG/MSLN tumors (2022)

Abstract In solid tumors, CAR T cell efficacy is limited by off-tumor toxicity, poor persistence, and suppression by the tumor microenvironment (TME). To address these challenges we have engineered AB-1015, an integrated circuit T cell (ICT cell) intended for the treatment of ovarian cancer. The AB-1015 transgene cassette encodes an “AND” logic gate designed to limit off-tumor toxicity through dual tumor antigen recognition and a dual shRNA-miR to resist TME suppression and improve ICT cell function and persistence. The AB-1015 DNA cassette is inserted into the T cell genome at a defined novel genomic site via CRISPR-based gene editing. The AB-1015 logic gate consists of a priming receptor that induces expression of an anti-mesothelin (MSLN) CAR upon engagement of a ALPG/P (alkaline phosphatase germ-line/placental). The dual-antigen specificity of the logic gate was assessed in mice engrafted with MSLN+ and ALPG/P+MSLN+ K562 tumors established on contralateral flanks. AB-1015 ICT cells eliminated ALPG/P+MSLN+ tumors, while sparing tumors that lacked ALPG/P. To assess the ability of AB-1015 to mediate killing of MSLN+ tumor cells in the context of heterogeneous cultures, we utilized an admixed co-culture system where ALPG/P+ target cells were spiked into cultures that were otherwise MSLN+. AB-1015 was able to eliminate admixed co-cultures where as few as 5-15% of the target cells expressed ALPG/P.The AB-1015 also contains a dual shRNA-miR that targets FAS and PTPN2, two critical mediators of T cells survival and function. FASL, the cognate ligand for FAS receptor, is expressed on the surface of activated T cells and is significantly overexpressed in the ovarian cancer TME. In vitro, AB-1015 demonstrated resistance to FAS-mediated apoptosis. Knockdown of PTPN2, a phosphatase involved in T cell proliferation and functional persistence, resulted in enhanced AB-1015 ICT cell expansion during repetitive stimulation over a period of 14 days, as well as a 30-fold reduction in tumor outgrowth compared with logic gated T cells alone. In summary, AB-1015 ICT cells are specific for ALPG/P+MSLN+, demonstrate superior potency, expansion, and persistence compared with logic gated T cells alone, and are resistant to ovarian TME suppression. These results support further evaluation of AB-1015 as a novel therapy for indications including ovarian, fallopian tube, or primary peritoneal cancer. Citation Format: Stephen Santoro, Aaron Cooper, Natalie Bezman, Jun Feng, Kanika Chawla, Jennifer McDevitt, Tarjei Mikkelsen, Susie Jun, W. Nicholas Haining. AB-1015, a novel integrated circuit T cells containing an ALPG/MSLN logic gate and FAS/PTPN2 shRNA-miR, demonstrates specific and potent activity against ALPG/MSLN tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 585.