gebhart/patrepeval huggingface dataset:
Experimental demonstration of soliton data transmission over unlimited distances with soliton control in time and frequency domains (1993)

A 29 – 1 pseudorandom-binary-sequence soliton signal has been transmitted experimentally over one million km for the first time with no degradation in the bit error rates. The synchronous modulator was driven by a timing clock signal extracted from the transmitting data signal. These results mean that it is possible to send soliton data signals over unlimited distances through the use of soliton control in the time and frequency domains.
Study of full load test method for large VSDS driven by non-regenerative VSI (2017)

Full load back-to-back test of VSDS's (Variable Speed Drive Systems) are sometimes required for oil and gas projects. VSI (Voltage Source Inverter) technology is becoming the drive system of choice for super large compressor drives, up to 100 MW. Special consideration /facilities are necessary to perform back-to- back tests for VSDS driven by VSI, because the type of converter used for such large VSI's is usually a diode rectifier without regenerative capability. To realize a back-to-back test for this type of VSDS, a VSI with regenerative converter, (usually adopting PWM converter topology), is necessary. But it is a heavy burden to prepare such super large VSI with regeneration capability purely as a test facility. This paper proposes a test method to increase the load test capacity of a back-to-back test facility up to two times the regenerative converter capacity. This idea is to apply a VSI with regenerative converter as a soft starter during start-up of back-to-back connected motor and generator system and as a constant voltage and constant frequency power supply during testing of VSDS. The proposed test facility is configured by direct connection of the load machine output to the input transformer of tested VSDS to circulate the load power directly. Only loss power and reactive power is supplied by VSI with regenerative converter.
A chemical biology view of bioactive small molecules and a binder-based approach to connect biology to precision medicines (2018)

A simplistic view of drug discovery is that it begins, most often using "model organisms", with biological inferences of a disease that suggest the need to interfere with some activity, function or process. An enzyme should be inhibited or a pathogen should be killed. Chemical experimentation yields the desired inhibitor, and clinical investigations then test the underlying hypothesis in humans. If the stars align, an effective drug emerges.
Arginine-Based Molecular Transporters:  The Synthesis and Chemical Evaluation of Releasable Taxol-Transporter Conjugates (2003)

[structure: see text] A flexible and efficient procedure has been developed for the conjugation of taxol to various arginine-based molecular transporters via the taxol C2' O-chloroacetyl derivative. The resultant taxol-transporter conjugates are highly water soluble and release free taxol with half-lives of minutes to hours depending on the pH and the linker structure.
Complex Systems: Science for the 21st Century (1999)

The workshop was designed to help define new scientific directions related to complex systems in order to create new understanding about the nano world and complicated, multicomponent structures. Five emerging themes regarding complexity were covered: Collective Phenomena; Materials by Design; Functional Systems; Nature's Mastery; and New Tools.
Plenary Panel: The Past, Present, and Future of Optical Design (2006)

Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text W. Smith, E. Betensky, D. Williamson, and J. Minano, "Plenary Panel: The Past, Present, and Future of Optical Design," in International Optical Design, Technical Digest (CD) (Optica Publishing Group, 2006), paper MA. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Purification of DNA‐Binding Proteins Using Biotin/Streptavidin Affinity Systems (1998)

Abstract This unit presents purification protocols that exploit the tight and essentially irreversible complex that biotin forms with streptavidin. A DNA fragment containing a high‐affinity binding site for the protein of interest is prepared and a molecule of biotinylated nucleotide is incorporated into one of the ends of the DNA fragment. The protein of interest is allowed to bind to the high‐affinity recognition site present in the biotinylated fragment. The tetrameric protein streptavidin is then bound to the biotinylated end of the DNA fragment. Next, the protein/biotinylated fragment/streptavidin ternary complex is efficiently removed by adsorption onto a biotin‐containing resin. Since streptavidin is multivalent, it is able to serve as a bridge between the biotinylated DNA fragment and the biotin‐containing resin. Proteins remaining in the supernatant are washed away under conditions that maximize the stability of the DNA‐protein complex. Finally, the protein of interest is eluted from the resin with a high‐salt buffer. Both batch and column formats are presented, as is a protocol for the use of streptavidin‐agarose. A support protocol describes a mobility shift assay for detecting sequence‐specific DNA‐binding proteins.
Effects of Voltages on Cows over a Complete Lactation. 1. Milk Yield and Composition (1992)

The effect of long-term voltage exposure on milk yield and composition was assessed. Forty cows in second to fifth lactation were used. Four groups of 10 Holstein cows were exposed to either 0, 1, 2, or 4 V throughout an entire lactation. Each group was housed in a free-stall environment with bunk feed and water provided for ad libitum intake. Voltages (AC, 60 Hz) were applied between waterers and a metal grid. Cows could not drink without placing their front hooves on the metal grid. Individual records were maintained for milk weights, milk fat, protein, and somatic cell counts. Average actual (7312, 8527, 6938, and 7725 kg for groups exposed to 0, 1, 2, or 4 V, respectively) and mature equivalent (7802, 9281, 7308, and 8911 kg for groups exposed to 0, 1, 2, or 4 V, respectively) milk weights for 305 d showed no significant differences between groups exposed or unexposed to voltage. Average actual milk yields for 305 d in the previous lactations were 8016, 8163, 7679, and 7876 kg for groups exposed to 0, 1, 2, or 4 V, respectively. Somatic cell counts, milk fat, and protein showed no significant differences between groups exposed or unexposed to voltage. Feed and water intakes were not affected by voltage.
Association of tumor necrosis factor-α and matrix metalloproteinase-3 gene variants with stroke (2011)

TNF-α +488 G/A variant is an important risk factor for ischemic stroke in the South Indians from Andhra Pradesh, whereas MMP-3-1612 5A/6A polymorphism is not associated with stroke in the same population.
<title>Nanostructured TiO<formula><inf><roman>2</roman></inf></formula> semiconductor electrodes modified with surface-attached viologens: applications for displays and smart windows</title> (1995)

Viologen derivatives adsorbed on TiO<SUB>2</SUB> surfaces in nanocrystalline-nanoporous electrodes have been studied with respect to electrochromic phenomena. The transparent nature and the high internal surface area of these electrodes are very beneficial for this purpose. Two different viologens were studied giving rise to blue, green, and violet coloration. For one of the viologens we show the possibility to vary the color for the same viologen/TiO<SUB>2</SUB> electrode from transparent to green or violet depending on the applied potential. Depending on the applied potential different optical densities were obtained. Optical density changes from 0.1 up to 1 and coloration efficiencies above 100 cm<SUP>2</SUP>C<SUP>-1</SUP>, with a maximum value of 440 cm<SUP>2</SUP>C<SUP>-1</SUP>, were obtained. The switching times for these electrodes for both coloration and bleaching were faster than 1s for a transmittance change larger than 60%, using 0.5M LiClO<SUB>4</SUB> in acetonitrile as electrolyte. Preliminary stability tests were performed. One electrode has been cycled 654 times without substantial decline in coloration efficiency.
Versatile gene-specific sequence tags for arabidopsis functional genomics : transcript profiling and reserve genetics applications (2004)

Microarray transcript profiling and RNA interference are two new technologies crucial for large-scale gene function studies in multicellular eukaryotes. Both rely on sequence-specific hybridization between complementary nucleic acid strands, inciting us to create a collection of gene-specific sequence tags (GSTs) representing at least 21,500 Arabidopsis genes and which are compatible with both approaches. The GSTs were carefully selected to ensure that each of them shared no significant similarity with any other region in the Arabidopsis genome. They were synthesized by PCR amplification from genomic DNA. Spotted microarrays fabricated from the GSTs show good dynamic range, specificity, and sensitivity in transcript profiling experiments. The GSTs have also been transferred to bacterial plasmid vectors via recombinational cloning protocols. These cloned GSTs constitute the ideal starting point for a variety of functional approaches, including reverse genetics. We have subcloned GSTs on a large scale into vectors designed for gene silencing in plant cells. We show that in planta expression of GST hairpin RNA results in the expected phenotypes in silenced Arabidopsis lines. These versatile GST resources provide novel and powerful tools for functional genomics
Fabrication of Micro-Chain Mail by Simultaneous, Patterned Electrodeposition on a Plane and Multiple Cylinders (2001)

Modeling with paper clips? No, a general method for the fabrication of complex three-dimensional (3D) microstructures is reported. The 3D structure is decomposed into substructures that can be patterned onto separate substrates and then these substrustures are joined to form the desired microstructure. The picture shows an optical micrograph of a free-linked nickel chain mail.
Electrically Tunable Mid-Infrared Metamaterials. (2012)

Abstract not provided.
The design of semi-synthetic and synthetic glycoconjugate vaccines (2011)

The immunogenicity of weak T-independent antigens can be increased in quantity and quality by conjugation to protein carriers, which provide T-cell help. Glycoconjugate vaccines are among the safest and most efficacious vaccines developed so far. Various conjugation procedures and carrier proteins can be used. Many variables impact on the immunogenicity of conjugate vaccines and a tight control through physicochemical tests is important to ensure manufacturing and clinical consistency. New and challenging targets for conjugate vaccines are represented by cancer and other non-infectious diseases.
The implementation of an emergency nursing framework (HIRAID) reduces patient deterioration: A multi-centre quasi-experimental study (2021)

Timely recognition and treatment of acutely ill patients at appropriate levels of the health system are fundamental to the quality and safety of healthcare. This study determines if the implementation of an emergency nursing framework HIRAID (History, Identify Red flags, Assessment, Interventions, Diagnostics, communication and reassessment) improves patient safety. A quasi-experimental cohort study was conducted in two emergency departments in [Anonymised], Australia. HIRAID was implemented using a multi-pronged behaviour change intervention. Data of 920 patients (374 pre and 546 post) who deteriorated within 72-hours of ED departure were collected. Statistical tests were conducted as two-sided, with a 95% confidence interval to determine pre/post cohort association. Patients in the post group had more comorbidities, but experienced less deterioration associated with care delivered in the ED (27% to 13%). There was a reduction in treatment delays [ 28.3% to 15.1%, p = 0.041, 95% CI (1.1%–25.3%)], and delay or failure to escalate care when abnormal vital signs were identified [20.2% to6.9%, p = 0.014, 95% CI (3.5%–23.1%)]. Isolated nursing-related causal factors decreased from 20 (21%) to 6 (8%). Implementing a standardised emergency nursing framework is associated with a reduction in clinical deterioration related to emergency care.
Cybersecurity Education (2014)

With the continuous growth of cyberinfrastructure throughout modern society, the need for secure computing and communication is more important than ever before. As a result, there is also an increasing need for entry-level developers who are capable of designing and building practical solutions for systems with stringent security requirements. This calls for careful attention to algorithm choice and implementation method, as well as trade-offs between hardware and software implementations. This article describes motivation and efforts taken by three departments at Rochester Institute of Technology (Computer Engineering, Computer Science, and Software Engineering) that were focused on creating a multidisciplinary course that integrates the algorithmic, engineering, and practical aspects of security as exemplified by applied cryptography. In particular, the article presents the structure of this new course, topics covered, lab tools and results from the first two spring quarter offerings in 2011 and 2012.
Fractal conceptualization of intumescent fire barriers, toward simulations of virtual morphologies (2019)

By limiting the heat spread during a fire hazard, intumescent coatings are important components of passive protection systems. They swell due to heat induced reactions of micro constituents and are transformed into carbonaceous porous-like media, known as intumescent chars. Their multiscale inner structures, key elements of performance, are costly to predict by recurrent and large scale fire testing while numerical simulations are challenging due to complex kinetics. Hence, we propose a novel approach using the fractal theory and the random nature of events to conceptualize the coating expansion. Experimental specimens were obtained from fire protective coatings exposed to bench scale hydrocarbon fire. Mass fractals were evidenced in the slices of 3D sample volumes reconstructed from X-ray microtomography. Consequently, geometrical building blocks were simulated by random walk, active walk, aggregation-like and site percolation: physical-chemical modes of action were inherent in the attribution of the randomness. It is a first demonstration to conceptualize different types of intumescent actions by a generalized approach with dimensionless parameters at multiscale, thus eliminating the simulation of complex kinetics to obtain a realistic morphology. Also, fractal results brought new evidence to former chemical analyses on fire test residues trying to explain the kinetics of expansion. Expected outcomes are to predict virtually the reaction of fire protective systems hence to speed-up the assessment of fire performance through computed properties of virtual volumes.
Effectiveness of dabrafenib in the treatment of patients with BRAF V600–mutated metastatic melanoma in a Named Patient Program (2019)

Given the approval of dabrafenib in patients with BRAF-mutant metastatic melanoma, a better understanding of treatment patterns and clinical outcomes with dabrafenib in a clinical setting is warranted. We performed a retrospective chart review of patients who received dabrafenib in a compassionate use setting through the Named Patient Program (DESCRIBE I study) during December 2010-August 2013 in Europe, New Zealand and Australia. Of the 331 Named Patient Program patients included, the majority (95.8%) had stage IV disease at dabrafenib initiation and 39.9% had brain metastases (BMs). Dabrafenib was used first line in 67.7% of patients, and median treatment duration was 6.4 months. Dabrafenib was well tolerated. Common grade 2/3 adverse events were hyperkeratosis (7.6%), pyrexia/fever (6.6%), fatigue (5.1%), hand-foot syndrome (5.4%) and nausea (3.6%). Overall response rate was 45.9%, median progression-free survival was 5.2 months (95% confidence interval, 4.2-6.1 months), and median overall survival was 12.4 months (95% confidence interval, 10.2-15.0 months). In patients with known brain metastases (n = 132) versus patients without (n = 199), overall response rate was 42.4% versus 48.2%, progression-free survival was 3.9 months (95% confidence interval, 3.8-5.5 months) versus 5.9 months (95% confidence interval, 4.8-7.8 months) and overall survival was 9.5 months (95% confidence interval, 6.7-12.4 months) versus 15 months (95% confidence interval, 11.1-20.5 months), respectively. Safety and effectiveness of dabrafenib in patients with unresectable advanced BRAF V600-mutant melanoma treated in an Named Patient Program was similar to the clinical trial experience, demonstrating effectiveness of dabrafenib in a nontrial setting.
Scale-bridging contrasting and characterization of multi-wire submerged arc welds and electron beam welds in steels (2023)

Abstract For a comprehensive microstructural characterization of welds, a scale-bridging analysis of the microstructure is required. It is the only way to identify all microstructural characteristics relevant for the mechanical properties which, in turn, may cover several observation scales. The analytical methods used range from etchings for the macroscopic evaluation of the weld and heat-affected zone to the detection of so-called “local brittle zones” (LBZs) in the micrometre range. This paper will study weld joints in low-alloy steels produced by multi-wire submerged arc welding and electron beam welding. Macro and micro etching as well as electropolishing will be used for microstructural contrasting. Scanning electron microscopy will be performed to identify the finely dispersed carbon-rich secondary phase. Electron backscatter diffraction will enable the identification of so-called martensite/austenite regions (MAs) capable of acting as LBZs.
A gate leakage current-powered loadless 4T SRAM with immunity against random dopant fluctuation and surface roughness in silicon-silicon dioxide interface (2022)

Abstract The sensitivities of the data hold, read and write performances for the gate leakage-powered loadless 4T SRAM cell on the variations in the MOSFETs’ gate leakage currents are examined by SPICE Monte Carlo simulations in 32 nm technology. The standard deviations in the gate leakage current variations are taken from the device simulation results in which the variations are caused by the random dopant fluctuation and the surface roughness in silicon-silicon dioxide interface. It is shown that the static noise margin (SNM) in the data hold state is 60 mV at 1 V power supply voltage for the −5 σ cell with the MOSFETs’ threshold voltage variations taken into consideration. The read SNM and the write SNM are shown to be 160 mV and 440 mV for the −5 σ cell, respectively, which are better than the 6TSRAM cell.
Expression of Self-antigen in the Thymus (2003)

For many years, it has been hypothesized that a major factor in organ-specific autoimmunity is a lack of central tolerance to self-antigens that are sequestered behind anatomical barriers in organs such as the eye, testis, and brain. However, numerous studies published in the last few years argue
Analyse du plomb par du papier carbone fonctionnalisé (2013)

Le plomb est un métal lourd bien connu pour sa toxicité pour l'homme et pour l'environnement, donc une méthode d'analyse précise et peu coûteuse est très souhaitable pour déterminer la teneur en plomb de divers spécimens. Ces dernières années, une attention particulière a été portée au développement de nouveaux capteurs électrochimiques pour quantifier les ions des métaux toxiques au niveau de trace. Le choix d'un matériau d'électrode et sa fonctionnalisation sont cruciaux pour le processus d'analyse. Le but principal de ce projet de recherche est de fonctionnaliser une électrode de papier carbone pour la détermination du plomb dans une solution aqueuse. À cet effet, le papier carbone activé, a été modifié avec de l'acide benzylphosphonique à partir de la réduction électrochimique des cations diazonium correspondants générés in-situ. La présence de la couche greffée a été confirmée et caractérisée par voltampérométrie cyclique, spectroscopie du photoélectron-X et par spectroscopie d'impédance électrochimique. Ainsi les groupements benzylphosphoniques, liés de manière covalente à la surface de l'électrode complexent les ions Pb2+ de la solution. La quantité de plomb complexée est déterminée par l'intégration de l'aire sous le pic d'oxydation ou de réduction d'un voltammogramme cyclique. Ces matériaux fonctionnels présentent une limite de détection de l'ordre de 0,034 µg.L-1 (S/N = 3) pour le plomb en solution. La détermination électrochimique du plomb a été examinée en variant différents paramètres tels que l'effet du pH de la solution d'immersion, l'effet du temps de préconcentration et aussi l'effet de la concentration du plomb en solution.&#13;\n______________________________________________________________________________ &#13;\nMOTS-CLÉS DE L’AUTEUR : Électrochimie, diazonium, amine, phosphate, modification, carbone, métaux lourds, eau.
Achieving low V<inf>T</inf> Ni-FUSI CMOS via lanthanide incorporation in the gate stack (2007)

This work reports that introducing lanthanide in the gate dielectric or in the gate electrode results, in both cases, in large effective work function (WF) modulation towards n-type band-edge for Ni-FUSI devices. This is done by: a) deposition of a Dy <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> capping layer on the host dielectric (SiON or HfSiON), or b) simple Yb implantation of nMOS poly gates prior to FUSI. We show that: 1) both cases result in dielectric modification with gate leakage (J <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">G</sub> ) reduction; 2) adding a cap has no significant impact on T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">inv</sub> (<1Aring), while up to ~5 and 2 A reduction occurs for SiON and HfSiON Yb-implanted devices, respectively; 3) the largest JG reduction (150 x) is obtained for capped SiON devices due to dielectric intermixing and formation of a new high-k dielectric (DySiON), comparable to HfSiON in JG and mobility but with 500 mV smaller V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> ; 4) on the other hand, being less invasive to the host dielectric, the optimized Yb I/I option gives 18% improved mobility compared to capped SiON devices; 5) excellent process control and reliability behavior (VT instability by a.c. pulsed IV, PBTI and TDDB) is reported for both WF tuning methods. They allow DeltaWF(n-p) values up to ~800 meV when combined with Ni-silicide FUSI phase engineering, promising for low-V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> CMOS.
Managing Foreign R&D in China (2007)

OVERVIEW:China has become one of the most desired locations in which to do R&D. However, it has little innovation of its own, and intellectual property protection is weak. This raises questions: Is China R&D more hype than reality? Do cost advantages really outweigh the risk of losing technology to Chinese competitors? Lessons learned from managing R&D in China show that in order to avoid the typical pitfalls of managing R&D in a developing country, any China-based R&D must be part of an overall China strategy and must also be part of a global R&D effort.