gebhart/patrepeval huggingface dataset:
Enhanced Drug Retention in VX2 Tumors by Use of Degradable Starch Microspheres (1984)

Twenty-nine rabbits with 12- to 14-day-old VX2 tumors in the hind leg were injected intraarterially with technetium-99m (99mTc) DTPA and various combinations of biodegradable starch microspheres, Spherex (Pharmacia, Sweden), to evaluate the efficacy of the microspheres in enhancing tumor retention of 99mTc DTPA. A gamma camera and nuclear medicine computer were used to generate time activity curves of 99mTc DTPA concentration in the tumors. Blood flow to the tumor and various muscles was also measured at intervals by left ventricular injection of 15 micron radiolabeled plastic microspheres. Ninety minutes following the administration of 99mTc DTPA, specimens from the tumor, plasma and different muscles were counted in a NaI well counter connected to a multichannel analyzer. When biodegradable microspheres mixed with 99mTc DTPA were injected and followed by a slow infusion of plain starch microspheres, the 99mTc DTPA was retained in the tumor at concentrations up to 11 times that seen when 99mTc DTPA alone was injected; the corresponding biological half-time was 13 times longer than control values. Additionally, the degree of drug retention was inversely related to blood flow, with retention increasing as blood flow decreased. The results have possible applications to the use of biodegradable microspheres in the intraarterial delivery of chemotherapeutic agents to solid tumors.
Molecular cloning of enantioselective ester hydrolase fromBacillus pumilusDBRL-191 (2005)

A gene from Bacillus pumilus expressed under its native promoter was cloned in Escherichia coli. Recombinant B. pumilus esterase (BPE) affects the kinetic resolution of racemic mixtures such as unsubstituted and substituted 1-(phenyl)ethanols (E approximately 33-103), ethyl 3-hydroxy-3-phenylpropanoate (E approximately 45-71), trans-4-fluorophenyl-3-hydroxymethyl-N-methylpiperidine (E approximately 10-13) and ethyl 2-hydroxy-4-phenylbutyrate (E approximately 7). The enzyme is composed of a 34-amino acid signal peptide and a 181-amino acid mature protein corresponding to a molecular weight of approximately 19.2kD and pI approximately 9.4. 3-D the structural model of the enzyme built by homology modelling using the atomic coordinates from the crystal structure of B. subtilis lipase (LipA) showed a compact minimal alpha/beta hydrolase fold.
Data from Topology of NGEP, a Prostate-Specific Cell:Cell Junction Protein Widely Expressed in Many Cancers of Different Grade Level (2023)

&lt;div&gt;Abstract&lt;p&gt;New gene expressed in prostate (NGEP) is a prostate-specific polytopic membrane protein found at high concentrations at cell:cell contact regions. To determine if NGEP is a useful target for antibody-based therapy of prostate cancer, we performed an immunohistochemical analysis of 126 human prostate carcinoma samples using polyclonal anti-NGEP sera and found that 91% of the cancers express NGEP protein. To elucidate the topology of NGEP and guide the development of monoclonal antibodies (mAb) reacting with the extracellular regions of NGEP, a hemagglutinin epitope tag was inserted at several positions within the NGEP sequence. The tagged proteins were expressed in 293T cells and locations of the tags were determined by immunofluorescence in intact or permeabilized cells. The results indicate that NGEP contains eight transmembrane domains with both the NH&lt;sub&gt;2&lt;/sub&gt; and COOH termini of NGEP located inside the cell. We produced mAb to three regions that are predicted to be intracellular based on the epitope tag data (amino acids 1-352, 441-501, and 868-933), and as predicted, the mAb only detected the protein in permeabilized cells. NGEP is a glycoprotein with predicted glycosylation sites at N809 and N824. When these residues were converted to glutamine, glycosylation was abolished, confirming that the residues are extracellular. Our findings on the expression and the orientation of the NGEP protein serve as an important framework for the development of mAb targeting the extracellular regions of NGEP that could be used for prostate cancer immunotherapy. [Cancer Res 2008;68(15):6306–12]&lt;/p&gt;&lt;/div&gt;
Management of information sharing in wireless environments (2002)

Presents a strategy for sharing intelligent transportation systems (ITS) information in a wireless, two-way automatic communications environment such as digital cellular and personal communications services (networks). It is assumed that communications can be initiated by the mobile or the service, with or without user intervention. Based on the demand of information, the availability of data channels, the server can dynamically move the clients from channel to channel in order to achieve better use of both network resources and information.
Towards Oxide Electronics: a Roadmap (2019)

At the end of a rush lasting over half a century, in which CMOS technology has been experiencing a constant and breathtaking increase of device speed and density, Moore's law is approaching the insurmountable barrier given by the ultimate atomic nature of matter. A major challenge for 21st century scientists is finding novel strategies, concepts and materials for replacing silicon-based CMOS semiconductor technologies and guaranteeing a continued and steady technological progress in next decades. Among the materials classes candidate to contribute to this momentous challenge, oxide films and heterostructures are a particularly appealing hunting ground. The vastity, intended in pure chemical terms, of this class of compounds, the complexity of their correlated behaviour, and the wealth of functional properties they display, has already made these systems the subject of choice, worldwide, of a strongly networked, dynamic and interdisciplinary research community.Oxide science and technology has been the target of a wide four-year project, named Towards Oxide-Based Electronics (TO-BE), that has been recently running in Europe and has involved as participants several hundred scientists from 29 EU countries. In this review and perspective paper, published as a final deliverable of the TO-BE Action, the opportunities of oxides as future electronic materials for Information and Communication Technologies ICT and Energy are discussed. The paper is organized as a set of contributions, all selected and ordered as individual building blocks of a wider general scheme. After a brief preface by the editors and an introductory contribution, two sections follow. The first is mainly devoted to providing a perspective on the latest theoretical and experimental methods that are employed to investigate oxides and to produce oxide-based films, heterostructures and devices. In the second, all contributions are dedicated to different specific fields of applications of oxide thin films and heterostructures, in sectors as data storage and computing, optics and plasmonics, magnonics, energy conversion and harvesting, and power electronics.
Array‐based DNA methylation profiling in acute myeloid leukaemia (2011)

Methylation in the promoter region of many genes is involved in regulating gene expression patterns. Using the Illumina GoldenGate© methylation assay, we examined the methylation status of 1505 CpG-sites from 807 genes in 32 samples from patients with acute myeloid leukaemia (AML) at diagnosis, nine at relapse and 15 normal controls and performed additional pyrosequencing and semiquantitative methylation specific polymerase chain reaction (MSP) of the GNMT promoter in 113 diagnostic AML samples. We found a gain of overall methylation in AML samples with a further increase at relapse. Regional hypermethylation as assessed by array analysis could be confirmed by both MSP and pyrosequencing. Additionally, large-scale methylation analysis identified interesting candidate genes. Cluster analysis indicated that cytogenetic subgroups seemed to be characterized by additional distinct epigenetic modifications and that basic DNA methylation patterns remain at relapse. Therefore, promoter hypermethylation is a frequent event in AML and is accentuated at relapse. Array-based methylation analysis determined distinct methylation profiles for non-malignant controls and AML samples with specific chromosomal aberrations and can identify target genes for further evaluation.
Fusing Meter-Resolution 4-D InSAR Point Clouds and Optical Images for Semantic Urban Infrastructure Monitoring (2016)

Using synthetic aperture radar (SAR) interferometry to monitor long-term millimeter-level deformation of urban infrastructures, such as individual buildings and bridges, is an emerging and important field in remote sensing. In the state-of-the-art methods, deformation parameters are retrieved and monitored on a pixel basis solely in the SAR image domain. However, the inevitable side-looking imaging geometry of SAR results in undesired occlusion and layover in urban area, rendering the current method less competent for a semantic-level monitoring of different urban infrastructures. This paper presents a framework of a semantic-level deformation monitoring by linking the precise deformation estimates of SAR interferometry and the semantic classification labels of optical images via a 3-D geometric fusion and semantic texturing. The proposed approach provides the first “SARptical” point cloud of an urban area, which is the SAR tomography point cloud textured with attributes from optical images. This opens a new perspective of InSAR deformation monitoring. Interesting examples on bridge and railway monitoring are demonstrated.
Identification of androgen, estrogen and progesterone receptor mRNAs in the eye (2000)

ABSTRACT. Purpose: Previous research has demonstrated that sex steroids exert a significant influence on the structure and function of numerous ocular tissues. To begin to explore the underlying basis of this hormone action, we examined whether various anterior and posterior tissues of the eye contain androgen, estrogen and progesterone receptor mRNAs. Methods: Tissue samples were obtained from adult male and female rats, rabbits and humans, processed for the isolation of total RNA and analyzed by RT‐PCR, agarose gel electrophoresis and Southern blot hybridization. All PCR amplifications included positive and negative controls. Results: Our findings showed that androgen, estrogen and/or progesterone receptor mRNAs are present in the lacrimal gland, lacrimal gland acinar epithelial cells, meibomian gland, lid, palpebral and bulbar conjunctivae, cornea, iris/ciliary body, lens, retina/uvea, retina/choroid and retinal pigment epithelial cells of rats, rabbits or humans. Conclusions: Our findings demonstrate that sex steroid receptor mRNAs exist in a variety of ocular tissues and suggest that these sites may represent target organs for androgens, estrogens and/or progestins.
Homoepitaxial growth and characterization of ZnO(0001) thin films grown by metalorganic chemical vapor epitaxy (2009)

Abstract We study the properties of Zn‐face ZnO(00.1) layers grown on the Zn‐face of high quality ZnO(00.1) single crystal wafers by metalorganic chemical vapour epitaxy. The layers are grown directly on the ZnO substrates without any treatment of the substrate before starting the growth. The growth temperature is varied between 600–1050 °C while the reactor pressure is kept at 50 Torr. Atomic force microscopy reveals monolayer steps with a step length of 170 nm. The root‐mean‐square roughness is 0.1 nm over a 20×20 μm 2 area. A two‐dimensional step morphology is only seen for growth temperatures above 950 °C. Layers grown below 950 °C exhibit very rough three dimensional surface morphologies. The full width at half maximum for x‐ray rocking curves is 22 arcsec and 36 arcsec across the (00.2) and the (20.1) reflections, respectively. This is comparable to the rocking curve widths of the as‐received substrates. The peaks of the ZnO epitaxial thin film and the substrate are indistinguishable in reciprocal space maps. (© 2009 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
CNoC: High-Radix Clos Network-on-Chip (2011)

Many high-radix network-on-chip (NoC) topologies have been proposed to improve network performance with an ever-growing number of processing elements (PEs) on a chip. We believe high-radix Clos network-on-chip (CNoC) is the most promising with its low average hop counts and good load-balancing characteristics. In this paper, we propose: 1) a high-radix router architecture with virtual output queue (VOQ) buffer structure and packet mode dual round-robin matching (PDRRM) scheduling algorithm to achieve high speed and high throughput in CNoC; 2) the design of hierarchical round-robin arbiter for high-radix high-speed NoC routers; and 3) a heuristic floor-planning algorithm to minimize the power consumption caused by the long wires. Experimental results show that the throughput of a 64-node three-stage CNoC under uniform traffic increases from 62% to 78% by replacing the baseline virtual channel routers with PDRRM VOQ routers. We also compared the delay, power, and area performance of the 64-node CNoC with other NoC topologies under various synthetic traffic patterns and SPLASH-2 benchmark traces. The simulation results show that in general CNoC improves the throughput, low-load delay, and energy efficiency over the compared NoC topologies.
Explaining Norms, by Geoffrey Brennan, Lina Eriksson, Robert E. Goodin, and Nicholas Southwood (2015)

Journal Article Explaining Norms , by Geoffrey Brennan, Lina Eriksson, Robert E. Goodin, and Nicholas Southwood Get access Explaining Norms , by Geoffrey Brennan , Lina Eriksson , Robert E. Goodin , and Nicholas Southwood . Oxford : Oxford University Press , 2013 . Pp. viii + 290 . H/b €35.00. Yair Levy Yair Levy Jesus College University of Oxford Turl St. Oxford OX1 3DW Search for other works by this author on: Oxford Academic Google Scholar Mind, Volume 124, Issue 494, April 2015, Pages 612–616, https://doi.org/10.1093/mind/fzv007 Published: 06 April 2015
Genetic screening for Niemann-Pick disease type C in adults with neurological and psychiatric symptoms: findings from the ZOOM study (2013)

Niemann-Pick disease type C (NP-C) is a rare, autosomal-recessive, progressive neurological disease caused by mutations in either the NPC1 gene (in 95% of cases) or the NPC2 gene. This observational, multicentre genetic screening study evaluated the frequency and phenotypes of NP-C in consecutive adult patients with neurological and psychiatric symptoms. Diagnostic testing for NP-C involved NPC1 and NPC2 exonic gene sequencing and gene dosage analysis. When available, results of filipin staining, plasma cholestane-3β,5α,6β-triol assays and measurements of relevant sphingolipids were also collected. NPC1 and NPC2 gene sequencing was completed in 250/256 patients from 30 psychiatric and neurological reference centres across the EU and USA [median (range) age 38 (18-90) years]. Three patients had a confirmed diagnosis of NP-C; two based on gene sequencing alone (two known causal disease alleles) and one based on gene sequencing and positive filipin staining. A further 12 patients displayed either single mutant NP-C alleles (8 with NPC1 mutations and 3 with NPC2 mutations) or a known causal disease mutation and an unclassified NPC1 allele variant (1 patient). Notably, high plasma cholestane-3β,5α,6β-triol levels were observed for all NP-C cases (n = 3). Overall, the frequency of NP-C patients in this study [1.2% (95% CI; 0.3%, 3.5%)] suggests that there may be an underdiagnosed pool of NP-C patients among adults who share common neurological and psychiatric symptoms.
Towards Accurate Markerless Human Shape and Pose Estimation over Time (2017)

Existing marker-less motion capture methods often assume known backgrounds, static cameras, and sequence specific motion priors, which narrows its application scenarios. Here we propose a fully automatic method that given multi-view video, estimates 3D human motion and body shape. We take recent SMPLify \cite{bogo2016keep} as the base method, and extend it in several ways. First we fit the body to 2D features detected in multi-view images. Second, we use a CNN method to segment the person in each image and fit the 3D body model to the contours to further improves accuracy. Third we utilize a generic and robust DCT temporal prior to handle the left and right side swapping issue sometimes introduced by the 2D pose estimator. Validation on standard benchmarks shows our results are comparable to the state of the art and also provide a realistic 3D shape avatar. We also demonstrate accurate results on HumanEva and on challenging dance sequences from YouTube in monocular case.
Metallo‐Scorpionates: First Generation of Trimetallic, Homoleptic [Ru]–M–[Ru] Complexes (M = Fe, Co, Ni, Cu) (2018)

The first metallo‐scorpionate ligands, closely related to Trofimenko's scorpionates, are obtained by formal replacement of the hydrido‐boron moiety of hydrido‐tris(pyrazolyl)borate by an (arene)Ru II fragment. Coordination to divalent and trivalent 3d‐transition metals (Fe, Co, Ni, Cu) gives access to a series of homoleptic, heterotrimetallic complexes containing linear metal chains bridged by pyrazole ligands. Synthetic aspects, spectroscopic, structural and electrochemical properties are reported and compared to those of standard scorpionate complexes.
Environmental Effects on Cellular Photosensitization: Correlation of Phototoxicity Mechanism with Transient Absorption Spectroscopy Measurements (1998)

Abstract— Little is directly known about the influence of the local environment experienced by a photosensitizer in a biological system on its photophysics and photochemistry. In this paper, we have addressed this issue by correlating mechanistic studies using laser flash photolysis with cellular phototoxicity data, obtained under the same experimental conditions. In particular, we have focused on the interaction between local concentrations of photosensitizer (deuteroporphyrin) and oxygen in determining the mechanism of phototoxicity in L1210 cells. In cells, as well as in models such as liposomes and red blood cell ghosts, hypochromicity and a reduction in fluorescence and intersystem crossing yields are observed on increasing the photosensitizer concentration between 0.5 and 20 μM, which illustrates the onset of a self-association. In aerated cellular preparations, the phototoxicity is predominantly type II (singlet oxygen) for all concentrations studied but an oxygen-independent mechanism occurs at the higher concentrations in deaerated samples. These observations are readily explained by consideration of triplet state kinetics as a function of oxygen and photosensitizer concentrations in cells. The rate constant for quenching of the photosensitizer triplet state by oxygen in cells was measured as 6.6 × 108 M−1 s−1 and by photosensitizer ground state as -106M−1s−1 (in terms of local concentration). The latter reaction gave rise to a long-lived species that is presumably responsible for the oxygen-independent phototoxicity observed at the higher photosensitizer concentrations used. This self-quenching of the triplet state is postulated to arise from electron transfer resulting in radical ion formation. Under conditions where no self-quenching contributes, the phototoxicity measured as a function of oxygen concentration correlates well with a model based on the determined kinetic parameters, thus, unambiguously proving the intermediacy of singlet oxygen. These effects should be borne in mind when interpreting phototoxicity mechanisms from in vitro cell studies. The excellent correlation achieved between laser flash photolysis data and measured phototoxicity gives credence to the direct use of photophysical techniques to elucidate photochemical mechanisms in biological media.
Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection (2020)

· ChIRP-MS of SARS-CoV-2 RNA identifies a comprehensive viral RNA-host protein interaction network during infection across two species· Comparison to RNA-protein interaction networks with Zika virus, dengue virus, and rhinovirus identify SARS-CoV-2-specific and pan-viral RNA protein complexes and highlights distinct intracellular trafficking pathways· Intersection of ChIRP-MS and genome-wide CRISPR screens identify novel SARS-CoV-2-binding proteins with pro- and anti-viral function· Viral RNA-RNA and RNA-protein interactions reveal specific SARS-CoV-2-mediated mitochondrial dysfunction during infection.
INTERACTION Dataset: An INTERnational, Adversarial and Cooperative moTION Dataset in Interactive Driving Scenarios with Semantic Maps (2019)

Behavior-related research areas such as motion prediction/planning, representation/imitation learning, behavior modeling/generation, and algorithm testing, require support from high-quality motion datasets containing interactive driving scenarios with different driving cultures. In this paper, we present an INTERnational, Adversarial and Cooperative moTION dataset (INTERACTION dataset) in interactive driving scenarios with semantic maps. Five features of the dataset are highlighted. 1) The interactive driving scenarios are diverse, including urban/highway/ramp merging and lane changes, roundabouts with yield/stop signs, signalized intersections, intersections with one/two/all-way stops, etc. 2) Motion data from different countries and different continents are collected so that driving preferences and styles in different cultures are naturally included. 3) The driving behavior is highly interactive and complex with adversarial and cooperative motions of various traffic participants. Highly complex behavior such as negotiations, aggressive/irrational decisions and traffic rule violations are densely contained in the dataset, while regular behavior can also be found from cautious car-following, stop, left/right/U-turn to rational lane-change and cycling and pedestrian crossing, etc. 4) The levels of criticality span wide, from regular safe operations to dangerous, near-collision maneuvers. Real collision, although relatively slight, is also included. 5) Maps with complete semantic information are provided with physical layers, reference lines, lanelet connections and traffic rules. The data is recorded from drones and traffic cameras. Statistics of the dataset in terms of number of entities and interaction density are also provided, along with some utilization examples in a variety of behavior-related research areas. The dataset can be downloaded via https://interaction-dataset.com.
Energy-based functional modeling for control architecture design: application to a hybrid electric vehicle (2017)

Seminar, Concordia University, Montréal, Canada
Fabrication of large-core, high-Δ optical waveguides in polymers (1995)

The realization of polymer optical waveguides that have a large core size and high refractive-index difference (LCHD) Δ transmission characteristics is presented. A fabrication procedure for the waveguide based on vertical dip coating and reactive ion etching has been studied. To achieve the lower propagation loss, this procedure includes two original techniques, i.e., the lamination of thick polymer films and sidewall flattening. With these techniques, Δ of 5.4% and a 80 µm × 83 µm core polymer waveguide with 1.4-dB/cm propagation loss were achieved at 680 nm. The LCHD polymer waveguides are useful for practical power-transmission devices.
Conformational studies by nuclear magnetic resonance—V:13C spectra and structural problems of enamino carbonyl compounds (1973)

Abstract A 13 C magnetic resonance investigation of 22 compounds of the general formula OC 1 (R 1 )C 2 (R 2 )C 3 (R 3 ) NR 4 R 4′ has been carried out in order to confirm the conformational assignments estimated previously by PMR and IR spectroscopy. The effects of nonplanarity and hindered rotation have been discussed based on chemical shifts and shapes of the C 1 , C 2 and C 3 signals.