gebhart/patrepeval huggingface dataset:
Data from <i>Intersex-like</i> (<i>IXL</i>) Is a Cell Survival Regulator in Pancreatic Cancer with 19q13 Amplification (2023)

&lt;div&gt;Abstract&lt;p&gt;Pancreatic cancer is a highly aggressive disease characterized by poor prognosis and vast genetic instability. Recent microarray-based, genome-wide surveys have identified multiple recurrent copy number aberrations in pancreatic cancer; however, the target genes are, for the most part, unknown. Here, we characterized the 19q13 amplicon in pancreatic cancer to identify putative new drug targets. Copy number increases at 19q13 were quantitated in 16 pancreatic cancer cell lines and 31 primary tumors by fluorescence &lt;i&gt;in situ&lt;/i&gt; hybridization. Cell line copy number data delineated a 1.1 Mb amplicon, the presence of which was also validated in 10% of primary pancreatic tumors. Comprehensive expression analysis by quantitative real-time reverse transcription-PCR indicated that seven transcripts within this region had consistently elevated expression levels in the amplified versus nonamplified cell lines. High-throughput loss-of-function screen by RNA interference was applied across the amplicon to identify genes whose down-regulation affected cell viability. This screen revealed five genes whose down-regulation led to significantly decreased cell viability in the amplified PANC-1 cells but not in the nonamplified MiaPaca-2 cells, suggesting the presence of multiple biologically interesting genes in this region. Of these, the transcriptional regulator intersex-like (&lt;i&gt;IXL&lt;/i&gt;) was consistently overexpressed in amplified cells and had the most dramatic effect on cell viability. &lt;i&gt;IXL&lt;/i&gt; silencing also resulted in G&lt;sub&gt;0&lt;/sub&gt;-G&lt;sub&gt;1&lt;/sub&gt; cell cycle arrest and increased apoptosis in PANC-1 cells. These findings implicate &lt;i&gt;IXL&lt;/i&gt; as a novel amplification target gene in pancreatic cancer and suggest that &lt;i&gt;IXL&lt;/i&gt; is required for cancer cell survival in 19q13-amplified tumors. [Cancer Res 2007;67(5):1943–9]&lt;/p&gt;&lt;/div&gt;
A Mobile Device Dual-Task Paradigm for the Assessment of mTBI (2019)

The optimal dual-task paradigm to evaluate cognitive-motor performance with minimal floor and ceiling effects consists of tandem stance with eyes closed while stimuli are presented at a rate of one per second.
Laser Additive Manufacturing with Crack‐sensitive Materials (2015)

Abstract Laser additive manufacturing is state‐of‐the‐art and regarded as a key technology in the future of production engineering [1]. Originating from a computer model, a new freedom of design can be achieved by simply adding layer by layer. Beyond the new perspectives and extended possibilities of conventional processes there are fields of application which already have been opened up. One of those is the highly innovative but demanding field of processing with heat resisting alloys (see Fig. 1). This field of engineering has traditionally been a door opener for hightech technologies such as aerospace or energy [2, 3].
Expression of Apolipoprotein B in the Kidney Attenuates Renal Lipid Accumulation (2010)

The ability to produce apolipoprotein (apo) B-containing lipoproteins enables hepatocytes, enterocytes, and cardiomyocytes to export triglycerides. In this study, we examined secretion of apoB-containing lipoproteins from mouse kidney and its putative impact on triglyceride accumulation in the tubular epithelium. Mouse kidney expressed both the apoB and microsomal triglyceride transfer protein genes, which permit lipoprotein formation. To examine de novo lipoprotein secretion, kidneys from human apoB-transgenic mice were minced and placed in medium with (35)S-amino acids. Upon sucrose gradient ultracentrifugation of the labeled medium, fractions were analyzed by apoB immunoprecipitation. (35)S-Labeled apoB100 was recovered in approximately 1.03-1.04 g/ml lipoproteins (i.e. similar to the density of plasma low density lipoproteins). Immunohistochemistry of kidney sections suggested that apoB mainly is produced by tubular epithelial cells. ApoB expression in the kidney cortex was reduced approximately 90% in vivo by treating wild type mice with apoB-antisense locked nucleic acid oligonucleotide. Inhibition of apoB expression increased fasting-induced triglyceride accumulation in the kidney cortex by 20-25% (p = 0.008). Cholesterol stores were unaffected. Treatment with control oligonucleotides with 1 or 4 mismatching base pairs affected neither the triglyceride nor the cholesterol content of the kidney cortex. The results suggest that mammalian kidney secretes apoB100-containing lipoproteins. One biological effect may be to dampen excess storage of triglycerides in proximal tubule cells.
Science with IMACS on Magellan (2003)

The Inamori-Magellan Areal Camera and Spectrograph is nearing completion. This reimaging spectrograph will have fields of view of 15 arcmin and 27 arcmin in its relecting grating and grism spectrographic modes, respectively, the largest such areas available on one of the new generation of large optical-IR ground-based telescopes. In addition to wide field imaging and a range of low- to medium-resolution spectroscopic modes, IMACS will have a 2 &times; 1000 fiber-fed integral field unit built by Durham University, an ecellette mode, and the potential for a full-field tunable filter. We review some of the planned science programs for IMACS, ranging from spectroscopy of stars in the Galactic halo and nearby dwarf spheroidal galaxies, the search for stars between galaxies, internal kinematics in normal galaxies and AGN, and the evolution of high redshift galaxies and galaxy clusters.
Delivery of triple-play services over broadband satellite networks (2010)

Digital video broadcast return channel via satellite system (RCS) is a key European standard that specifies a broadband satellite system using dynamic capacity assignment and multi-frequency time-division multiple access. This study introduces new architectural components for an RCS system to support advanced Internet protocol (IP)-oriented multimedia. This will allow closer integration of satellite networks with the next generation of multimedia-enabled networks enabling operators to offer triple-play services that simultaneously support voice over IP, television-over IP and other services. These types of services are particularly suited to next generation satellite systems that combine transparent and multi-spot beam satellites with on-board regenerative signal processing, and can evolve to use adaptive coding and modulation.
Prevalência e relação de fatores emocionais e clínicos em pacientes com discopatia degenerativa Prevalence and relationship of emotional and clinical factors in patients with degenerative disc disease La prevalencia y la relación de los factores clínicos y los trastornos emocionales en pacientes con discopatia degenerativa del disco (2010)

Objectives: to describe the psychosocial conditions, at the time of surgical indication, of patients with chronic low back pain caused by degenerative disc disease. Methods: in a series of 32 cases of degenerative disc disease elective surgery, a psychological evaluation was performed before the surgery. In this evaluation, socio-demographic data were collected: gender; age; present working status; occurrence of withdrawal due to disability; and clinical-psychological data: pain; physical restraint; use of psychiatric medication controlled; degree of anxiety; degree of depression; degree of hopelessness; expectations before the surgical goal. Results: the group was composed of 13 women and 14 men, mean age of 44.3 years old (23 to 65 years). The parameters of pain and physical restraint were compared to cases usually indicative of surgery, indicating no
Implementing a shared dataspace language on a message-based multiprocessor (1989)

article Implementing a shared dataspace language on a message-based multiprocessor Share on Authors: G.-C. Roman Department of Computer Science, Washington University, Saint Louis, Missouri Department of Computer Science, Washington University, Saint Louis, MissouriView Profile , K. C. Cox Department of Computer Science, Washington University, Saint Louis, Missouri Department of Computer Science, Washington University, Saint Louis, MissouriView Profile Authors Info & Claims ACM SIGSOFT Software Engineering NotesVolume 14Issue 3May 1989 pp 41–48https://doi.org/10.1145/75200.75206Online:01 April 1989Publication History 2citation182DownloadsMetricsTotal Citations2Total Downloads182Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Abstract 2681: Identification of potential immunologic targets found in mice and man that are expressed in colon adenomas and colorectal cancer (2011)

Abstract Multiple recent studies have demonstrated that colorectal cancer (CRC) is immunogenic and that host adaptive immunity may play a role in inhibiting disease relapse. We have shown that overexpressed tumor associated proteins, those abundant in the cancer state but expressed at basal levels normal cells, can be immunogenic. The purpose of this study was to identify genes overexpressed in colorectal adenoma that maintain upregulation in CRC using publicly available microarray datasets in the Gene Expression Omnibus. Such genes may encode proteins that could be suitable as immunologic targets for a colon cancer vaccine. We identified 7 high-quality datasets (GSE 867, 4183, 1095, 5206, 15960) where human adenomatous or CRC tissue was directly compared to normal colon. Inclusion criteria for the datasets included: commercial platforms, primary tissue, normal colon expression included, data generated after 2005, and access to microarray data. We reanalyzed these datasets and identified 100 genes that were ≥ 2-fold up-regulated in both adenomas and CRC, relative to normal colon. We further characterized these genes using a scoring system using the following criteria: 1) strong expression in CRC as compared to normal colon (RNA and protein), 2) evidence that the gene is biologically important in CRC initiation or progression, 3) limited expression of the gene in normal tissues, and 4) proven immunogenicity of the encoded protein. We hypothesized that genes that were highly conserved across species would potentially have greater biologic relevance, so we identified relevant microarray studies in mouse CRC models. We identified 2 studies (GSE 422, 784) which were limited in their data set and performed a similar analysis. We identified 93 murine genes that were conserved from adenoma to carcinoma. Comparison of the human and rodent data set revealed an overlap of 11 genes. We conclude that there are a limited number of genes up-regulated in adenoma and carcinoma and conserved across disease in mouse and man. If these proteins are immunogenic, they may serve as novel immunologic targets to prevent the progression from normal colonic epithelium to adenoma or carcinoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2681. doi:10.1158/1538-7445.AM2011-2681
Large magnetostriction in Terfenol-D particulate composites with preferred [112] orientation (2001)

Terfenol-D particulate composites have been fabricated with and without a preferred crystal orientation of the particles. A 25% volume fraction polymer matrix composite was fabricated in a magnetic field using geometric anisotropy to orient needle shaped particles with long axis [112] orientation along the length of the composite. Results demonstrate that the magnetostriction of a [112] oriented particle composite saturates near 1600 ppm. This is a significant increase when compared to composites without preferential orientation (1200 ppm). The oriented particle composite exhibits the largest reported magnetostriction for a particulate composite material. The magnetization-strain measurements indicate that the strain in the oriented composite is proportional to the (lambda) <SUB>112</SUB> saturation magnetostriction while the non-oriented composite is proportional to the polycrystalline saturation magnetostriction, (lambda) <SUB>pc</SUB>. In addition, the fields necessary for equivalent magnetostriction in the oriented particle composite are reduced when compared to the non-oriented composite, though both require higher fields than commercially available monolithic Terfenol-D.
Regenerative pulmonary medicine: potential and promise, pitfalls and challenges (2012)

Cell-based regenerative therapies for lung diseases offer great promise, with preclinical studies suggesting that the next decade should provide the evidence necessary for their ultimate application to our therapeutic armamentarium.
Enabling Fluorinated MOF‐Based Membranes for Simultaneous Removal of H2S and CO2 from Natural Gas (2018)

Abstract Membrane‐based gas separations are energy efficient processes; however, major challenges remain to develop high‐performance membranes enabling the replacement of conventional separation processes. Herein, a new fluorinated MOF‐based mixed‐matrix membrane is reported, which is formed by incorporating the MOF crystals into selected polymers via a facile mixed‐matrix approach. By finely controlling the molecular transport in the channels through the MOF apertures tuned by metal pillars and at the MOF‐polymer interfaces, the resulting fluorinated MOF‐based membranes exhibit excellent molecular sieving properties. These materials significantly outperform state‐of‐the‐art membranes for simultaneous removal of H 2 S and CO 2 from natural gas—a challenging and economically important application. The robust fluorinated MOFs (NbOFFIVE‐1‐Ni, AlFFIVE‐1‐Ni), pave a way to efficient membrane separation processes that require precise discrimination of closely sized molecules.
Control of the Immune Response: Role of Macrophages in Regulation of Antibody‐and Cell‐Mediated Immune Responses (1976)

The ability of peritoneal macrophage subpopulations, separated into different classes according to their size, to reconstitute antibody or cellular immune responses in macrophage-depleted spleen cells has been investigated. Data are presented to show that whether reconstitution is by "normal" or "activated" macrophages, be they syngeneic or allogeneic to the lymphocyte source, different populations reconstitute antibody and cellular immunity. Reconstitution is in general by two classes of macrophages, small and large. The former seem to reconstitute only if syngeneic to the responding lymphocyte pool, whereas large macrophages reconstitute immune responses from allogeneic lymphocytes as well as syngeneic lymphocytes. Evidence is also presented to show that syngeneic large macrophages can determine the type of immune response reconstituted; that is, with greater numbers of large cells only cytotoxic responses (and not T-dependent antibody formation) were reconstituted and vice versa.
Pricing and bidding strategies for cloud computing spot instances (2017)

We consider a cloud service based on spot instances and explore bidding and pricing strategies aimed at optimizing users' utility and provider's revenue, respectively. Our focus is on jobs that are heterogeneous in both valuation and sensitivity to execution delay. Of particular interest is the impact of correlation in these two dimensions. We characterize optimal bidding and pricing strategies under some simplifying assumptions, and more importantly highlight the impact of correlation in determining the benefits of a spot service over an on-demand service. We also provide a preliminary assessment of the results' robustness under more general assumptions.
Depth Coding Using a Boundary Reconstruction Filter for 3-D Video Systems (2011)

A depth image is 3-D information used for virtual view synthesis in 3-D video system. In depth coding, the object boundaries are hard to compress and severely affect the rendering quality since they are sensitive to coding errors. In this paper, we propose a depth boundary reconstruction filter and utilize it as an in-loop filter to code the depth video. The proposed depth boundary reconstruction filter is designed considering occurrence frequency, similarity, and closeness of pixels. Experimental results demonstrate that the proposed depth boundary reconstruction filter is useful for efficient depth coding as well as high-quality 3-D rendering.
Abstract 5722: Acquired stemness by luminal cells (2020)

Abstract Rare cell types in the prostate are reported to have stem cell properties based on organ regeneration potential following castration. Here, we use single cell RNA-seq (scRNA-Seq) to characterize these populations from the murine and human prostate in hormonally intact and androgen deprived conditions. Prostate cells from hormonally intact mice partitioned into one large subset of basal epithelial cells, another large subset of luminal epithelial cells, which we designate luminal 1 and two rare luminal populations: luminal 2 and luminal 3. Luminal cells that persist following castration display enhanced organoid regeneration potential, particularly within 1-2 days of androgen addback, and contribute equipotently to prostatic regeneration as revealed by lineage tracing. This regeneration is mediated, in part, through the orchestrated expression of Nrg2, Igf1, Fgf10 and Rspo3 by distinct populations of androgen-responsive mesenchymal and smooth muscle cells. Thus, luminal cells that persist post-castration undergo a cell state change that primes a proliferative response to microenvironment signals, analogous to other models of tissue injury such as liver damage. Citation Format: Wouter Karthaus, Matan Hofree, Danielle Choi, Eliot L. Linton, Mesruh Turkekul, Alborz Bejnood, Brett Carver, Anuhandra Gopalan, Vincent Laudone, Moshe Biton, Ojasvi Chaudhary, Ignas Masilionis, Linas Mazutis, Dana Pe'er, Aviv Regev, Charles Sawyers. Acquired stemness by luminal cells [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 5722.
ChemInform Abstract: Synthesis and Biological Activity of Cyclic Analogues of MPPG and MCPG as Metabotropic Glutamate Receptor Antagonists. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Novel Heterocyclic Enediynes. Molecular Design, Chemical Synthesis and DNA Cleavage (1997)

The novel 10-membercd oxaenediyne (4a) and azaenediynes (5a-d) were designed and synthesized in a short procedure, and the azaenediynes (5a-d) were found to effectively cleave DNA under both weakly acidic and basic conditions with no additive.DNA cleaving molecules, particularly those with a simple structure and high efficiency, have considerable potential in chemistry, molecular biology, and medicine.lTherefore; much attention has been directed towards the design and synthesis of novel DNA cleaving molecules in relation to the powerful anticancer and DNA cleaving enediyne antibiotics such as neocalzinostatin, calicheamicins, esperamicins, dynemicins, kedarcidin, and C-1027.2These molecules undergo Masamune-Bergman or Saito-Myers cyclization under suitable conditions to generate benzenoid diradicals which can then damage D N A .~ We recently reported
High Contrast of Scanning Ion Microscopy Images Shows Element Segregation (1991)

Scanning ion microscopy (SIM) provides image contrast clearly higher than that of scanning electron microscopy (SEM). SEM and SIM images of the same sample have been taken in the same instrument under the same field of view conditions, and then compared. SIM reveals element segregation, but SEM does not. It is shown that the elemental contrast of SIM, when using positive secondary ions as the imaging signal, is made by variation of the secondary ion yield of the implanted primary beam element. The variation is caused by differences of sample elements. The high contrast provided by SIM gives valuable information about elements and microcrystallites in material science.
Electronic Unit Integrated Into A Flexible Polymer Body (2023)

A peel and stick electronic system comprises a silicone body, and at least one electronic unit operatively connected to the silicone body. The electronic system is produce by providing a silicone layer on a substrate, providing a metal layer on the silicone layer, and providing at least one electronic unit connected to the metal layer.
Measurement of the four-lepton invariant mass spectrum in 13 TeV proton-proton collisions with the ATLAS detector (2019)

A bstract A measurement of the four-lepton invariant mass spectrum is made with the ATLAS detector, using an integrated luminosity of 36.1 fb −1 of proton-proton collisions at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 TeV delivered by the Large Hadron Collider. The differential cross-section is measured for events containing two same-flavour opposite-sign lepton pairs. It exhibits a rich structure, with different mass regions dominated in the Standard Model by single Z boson production, Higgs boson production, and Z boson pair production, and non-negligible interference effects at high invariant masses. The measurement is compared with state-of-the-art Standard Model calculations, which are found to be consistent with the data. These calculations are used to interpret the data in terms of gg → ZZ → 4 ℓ and Z → 4 ℓ subprocesses, and to place constraints on a possible contribution from physics beyond the Standard Model.
Leaving no aspect of sustainability behind: A framework for designing sustainable energy interventions applied to refugee camps (2022)

The issues of forced displacement and energy for sustainable development are convergent: an estimated 90% of displaced people globally have no access to electricity, while 85% of refugees are hosted in developing countries. However, few tools to plan and design sustainable energy access interventions have been transposed to displacement settings. This paper presents a novel framework for the holistic planning of energy projects which considers both sustainability aspects and the specificities of displacement settings. The framework is the result of a review of literature which aimed to define a “sustainable energy intervention” in displacement contexts and an assessment of relevant planning tools against this definition. The framework includes the use of an energy delivery model toolkit, an inclusive design approach, an assessment of the desired impacts, energy system modelling, business model design, and an assessment of economic viability. We apply the framework in the design of a solar mini grid of Holl Holl refugee camp in Djibouti, in which a sustainable intervention and business model are proposed that could be compatible with the local conditions. We highlight issues that arise from the humanitarian sector status quo and propose that this framework could help to enhance sustainable energy practices in the humanitarian and development sectors.