gebhart/patrepeval huggingface dataset:
Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study (2009)

Chronic obstructive pulmonary disease (COPD) is considered an inflammatory pulmonary disorder with systemic inflammatory manifestations. The aim of this study was to assess the systemic levels of six inflammatory mediators in a large cohort of COPD patients and controls. 409 COPD patients and 231 healthy subjects, aged 40-75 yrs, were included from the first phase of the Bergen COPD Cohort Study. All COPD patients were clinically diagnosed by a physician, and had a forced expiratory volume in 1 s/forced vital capacity ratio less than 0.7 and a smoking history of >10 pack-yrs. The plasma levels of C-reactive protein (CRP), soluble tumour necrosis factor receptor (sTNFR)-1, osteoprotegrin, neutrophil activating peptide-2, CXCL16 and monocyte chemoattractant protein-4 were determined by ELISA. After adjustment for all known confounders, COPD patients had significantly lower levels of osteoprotegrin than subjects without COPD (p<0.05), and higher levels of CRP (p<0.01). Among COPD patients, CRP was elevated in patients with frequent exacerbations (p<0.05). sTNFR-1 and osteoprotegrin were both related to Global Initiative for Chronic Obstructive Lung Disease stage and frequency of exacerbations in the last 12 months (p<0.05). In addition, sTNFR-1 was significantly associated with important comorbidities such as hypertension and depression (p<0.05). The present study confirms that certain circulating inflammatory mediators are an important phenotypic feature of COPD.
Water efficiency management in datacenters: Metrics and methodology (2009)

The demand for data center solutions with lower total cost of ownership and lower complexity of management is driving the creation of next generation datacenters. The information technology industry is in the midst of a transformation to lower the cost of operation through consolidation and better utilization of critical data center resources. Successful consolidation necessitates increasing utilization of capital intensive ldquoalways-onrdquo data center infrastructure, reduction in the recurring cost of power and management of physical resources like water. A 1MW data center operating with water-cooled chillers and cooling towers can consume 18,000 gallons per day to dissipate heat generated by IT equipment. However, this water demand can be mitigated by appropriate use of air-cooled chillers or free cooling strategies that rely on local weather patterns. Water demand can also fluctuate with seasons and vary across geographies. Water efficiency, like energy efficiency is a key metric to evaluate sustainability of the IT ecosystem. In this paper, we propose a procedure for calculation of water efficiency of a datacenter and provide guidance for a management system that can optimize IT performance while managing the tradeoffs between water and energy efficiency in conventional datacenters.
The beaver facilitates species richness and abundance of terrestrial and semi-aquatic mammals (2019)

Beavers are ecosystem engineers which are capable to facilitate many groups of organisms. However, their facilitation of mammals has been little studied. We applied two methods, camera trapping and snow track survey to investigate the facilitation of a mammalian community by the ecosystem engineering of the American beaver (Castor canadensis) in a boreal setting. We found that both mammalian species richness (83% increase) and occurrence (12% increase) were significantly higher in beaver patches than in the controls. Of individual species, the moose (Alces alces) used beaver patches more during both the ice-free season and winter. The Eurasian otter (Lutra lutra), the pine marten (Martes martes) and the least weasel (Mustela nivalis) made more use of beaver sites during the winter. Our study highlights the role of ecosystem engineers in promoting species richness and abundance, especially in areas of relatively low productivity. Wetlands and their species have been in drastic decline during the past century, and promoting facilitative ecosystem engineering by beaver is feasible in habitat conservation or restoration. Beaver engineering may be especially valuable in landscapes artificially deficient in wetlands.
Abstract 1299: Potential antitumor effects of a Golgi disrupting agent, M-COPA, via targeting cell-extracellular matrix interaction under the spheroid culture conditions (2019)

Abstract The Golgi apparatus plays an essential role in the transport, processing, and sorting of cell surface proteins. We previously demonstrated that a Golgi disrupting agent, 2-methylcoprophilinamide (M-COPA), exhibited antitumor effect in human cancer cells in vitro and in vivo; however, in vivo antitumor efficacy of M-COPA did not simply reflect its in vitro efficacy, probably due to the lack of microenvironmental features of tumor tissues in the monolayer culture conditions. To bridge the gap between in vitro and in vivo efficacies, we exploited 3-dimensional (3D) spheroid culture models, which can recapitulate physiological characteristics of tumor tissues; i.e., nutrient/oxygen gradient, cell-cell interaction and cell-extracellular matrix (ECM) interaction, if cancer cells synthesize their own ECM molecules. Interestingly, human gastric cancer MKN1 cells displayed hypersensitivity to M-COPA under the 3D culture conditions compared to those in the monolayer culture conditions. Especially, we found that M-COPA caused loss of spheroid integrity. We previously demonstrated that M-COPA exerted antitumor effects via inhibiting intracellular transport of receptor tyrosine kinases onto the cell surface. Therefore, we examined the involvement of cell adhesion molecules in the antitumor effect of M-COPA. As a result, we found that specific integrins, which serve as cell surface receptors responsible for cell-ECM adhesion, were overexpressed and their downstream signaling molecules such as Src, Akt and MEK/ERK were highly phosphorylated in the cells under the 3D culture conditions compared to those under the monolayer culture conditions. Upon exposure to M-COPA, cell surface expression of these integrins was efficiently decreased and the downstream signaling molecules were dephosphorylated along with loss of spheroid integrity. Moreover, expression knockdown or neutralizing antibody of the integrins clearly suppressed sphere formation of MKN1 cells. These results suggest that M-COPA exerted in vivo antitumor effects via targeting specific integrins that mediate cell-matrix adhesion and its downstream intracellular signaling pathway observed in 3D spheroid culture models. Citation Format: Yoshimi Ohashi, Kazuma Takeuchi, Mutsumi Okamura, Akinobu Akatsuka, Isamu Shiina, Kentaro Yoshimatsu, Shingo Dan. Potential antitumor effects of a Golgi disrupting agent, M-COPA, via targeting cell-extracellular matrix interaction under the spheroid culture conditions [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1299.
Nanocomposite Cellulose Fibres Doped with Graphene Oxide and Their Biocidal Properties (2021)

The paper presents a method of obtaining composite cellulose fibres (CEL) doped with graphene oxide (GO) and the influence of GO nanoparticles on the structure and properties of the obtained fibres. Composite fibres (GO/CEL) were prepared using wet method from 5% CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) containing GO (0; 0.21; 0.50; 0.98; 1.97% <i>w/w</i>) dispersion in N,N-dimethylformamide (DMF). The fibres were coagulated in distilled water and methanol. Optical microscopy allowed us to demonstrate a good degree of GO additive dispersion in the CEL matrix. Surface morphology was examined by scanning electron microscopy (SEM) and infrared spectroscopy (FTIR), which indicated interactions between the matrix and the additive. Strength tests have shown that GO/CEL fibres are characterised by high values of elongation at break (7.7-19.5%) and tenacity (~133-287 [MPa]). The obtained composite fibres are characterized by good biocidal properties against Gram-negative bacteria (<i>Escherichia coli</i>), Gram-positive bacteria (<i>Staphilococcus aureus</i>), and fungi <i>Candida albicans</i>, and the resistance to microorganisms depends on the surface zeta potential value and the isoelectric point (IEP) of GO/CEL fibres.
Semi-Active Steering Damper Control in Two-Wheeled Vehicles (2010)

This work presents the design of innovative control strategies for a semi-active steering damper aimed at improving two-wheeled vehicles steering stability by controlling the weave and wobble modes. The proposed control strategies arise from a parallelism between steering and vertical dynamics of a motorcycle. According to this parallelism, the Sky-Hook (SH) and Ground-Hook (GH) damping concepts are adapted to the control of steering dynamics. A detailed analysis of the two approaches shows that a tradeoff arises between the damping of wobble and weave mode. It is then shown that the tradeoff can be solved by mixing the SH and GH strategies according to a frequency-range selector. The closed-loop stability properties are investigated via passivity theory. Further, both a multibody simulator and experimental data are employed to validate both the modeling phase and the control strategies performance.
Game Theory Cancer Models of Cancer Cell-Stromal Cell Dynamics using Interacting Particle Systems (2020)

We describe an evolutionary game theory model that has been used to predict the population dynamics of interacting cancer and stromal cells. We first consider the mean field case assuming homogeneous and nondiscrete populations. Interacting Particle Systems (IPS) are then presented as a discrete and spatial alternative to the mean field approach. Finally, we discuss cases where IPS gives results different from the mean field approach.
Interferometric mapping of material properties using thermal perturbation (Conference Presentation) (2018)

Optical phase changes induced by transient perturbations provide a sensitive measure of material properties. One such measure is associated with the change in refractive index with temperature. Another - with thermal expansion. We demonstrate the high sensitivity and speed of such methods using two interferometric techniques: Quantitative Phase Imaging (QPI) in transmission, and phase-resolved Optical Coherence Tomography (OCT) in reflection. Camera frame rate in QPI varied from 10 to 50 kHz, exposure from 1 to 10 µs, and heating pulse – from 0.02 to 1 ms in duration. The phase-stabilized swept-source OCT was operating at 100 kHz repetition rate. Shot-noise limited QPI can resolve energy deposition of about 3.4 mJ/cm^2 in a single pulse, which corresponds to 0.8 ℃ temperature rise in a single cell. OCT can detect deposition of 24 mJ/cm^2 energy between two scattering interfaces producing about 30 dB SNR signals and 4.7 mJ/cm^2 with 45 dB. Finite element modeling of the phase changes in materials heated by laser and by electric current matched the experimental results very well. These techniques can be used for mapping absorption coefficients, electric current density, doping depth in semiconductors, and many other properties. Integration of the phase changes along the penetrating beam path helps increase sensitivity and reveals the size of the hidden objects by looking at the signal relaxation time. These methods may enable multiple applications, ranging from temperature control in retinal laser therapy and in gene expression to characterization of semiconductor devices.
Processing of the 2S Storage Protein Pronapin in Brassica napus and in Transformed Tobacco (1995)

The 2S protein napin in Brassica napus is synthesized as a proprotein from which an N-terminal an an internal propeptide are removed. In order to investigate the mechanism of 2S storage-protein processing, N-terminal sequences were determined for the light and heavy chains of all major napin isoforms isolated. Mutants of a napin gene, with deletions of different portions of the propeptides, were transformed into tobacco and napin protein was isolated. Napin light and heavy chains were separated and their N-terminal amino acid sequences determined. Further, the C-terminal residues of one napin isoform isolated from B. napus and one mutant napin isolated from tobacco were deduced from molecular-mass determinations of the constituents chains. Analyses suggested that the two propeptides are exposed at the surface of the proprotein. The light chain is processed to the correct length independent of the amino acid sequence in the N-terminal propeptide and the processing site. The internal propeptide is attacked by endoproteases. Aminopeptidases and carboxypeptidases then digest portions of the propeptide to the extent allowed by the primary and the three-dimensional structures, often resulting in 2S protein chains with partly frayed ends.
Efficient Charge Generation Via Hole Transfer in Dilute Organic Donor-Fullerene Blends (2019)

&lt;p&gt;Efficient organic photovoltaics (OPVs) require broadband charge photogeneration with near-unity quantum yield. This can only be achieved by exploiting all pathways that generate charge. Electron transfer from organic donors to acceptors has been well-studied and is considered the primary path to charge photogeneration in OPVs. In contrast, much less is known about the hole transfer pathway. &lt;/p&gt;&lt;p&gt;Here we study charge photogeneration in an archetypical system comprising tetraphenyldibenzoperiflanthene: C70 blends using our recently developed multispectral two dimensional electronic spectroscopy (M-2DES), supported by time-dependent density functional theory and fully quantum-mechanical Fermi’s golden rule rate calculations. Our approach identifies in real time two rapid charge transfer pathways that are confirmed through computational analysis. Surprisingly, we find that both electron and hole transfer occur with comparable rates and efficiencies, facilitated by donor-acceptor electronic interactions. Our results highlight the importance of the hole transfer pathway for optimizing the efficiency of OPV devices employing small-molecule heterojunctions.&lt;br&gt;&lt;/p&gt;
A novel nanopolymer based tumor targeted delivery system for paclitaxel (2008)

11095 Background: We have developed a novel cremophor-free paclitaxel formulation-Nanoxel in which the drug is delivered as nanomicelles using a polymeric carrier. Our phase I data has previously shown that Nanoxel™ has linear pharmacokinetics and can be administered without premedication. The phase II data in metastatic breast cancers showed comparable efficacy and better safety profile than cremophor paclitaxel. We report here the putative mechanism of action of nanoxel. Methods: We have designed and synthesized a pH sensitive co-polymer of N-isopropyl acrylamide (NIPAM) and vinylpyrrolidone (VP) monomers. The nanomicelles were characterized for size and morphology by scanning electron microscopy (SEM). The journey of nanomicelles after systemic administration was tracked using chromatographic methods and transmission electron microscopy (TEM). The cellular uptake studies were carried out in target cancers and the tumor uptake was assessed in xenograft models. Release of intracellular Paclitaxel from the nanomicelles in the lysosomal compartment was correlated with the in vitro release of the drug at varying pH conditions. Tubulin polymerization and apoptosis were assessed by standard techniques. Results: Paclitaxel was found to retain the in vitro cytotoxicity in nanomicellar particles. Smooth spherical particles of 80 -100 nm were observed by SEM. Nanoxel™ showed upto three-fold higher uptake in target cancer cells as compared to cremophor paclitaxel. TEM demonstrated that the nanomicelles were endocytosed and entrapped in the acidic endolysosomal compartment. In vitro release of paclitaxel was faster at lower pH conditions. This resulted in an increase in tubulin stabilization & induction of apoptosis. Conclusion: Our data delineates the putative mechanism of action of nanoxel, which may explain its clinical efficacy & improved safety. It also suggests that this nanopolymer is a novel pH sensitive tumor targeting delivery system with potential for application to other hydrophobic drugs. No significant financial relationships to disclose.
Chemoenzymatic Synthesis of (S)‐ and (R)‐Propranolol and Sotalol Employing One‐Pot Lipase Resolution Protocol. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
ChemInform Abstract: Synthesis of Novel Di‐ and Tricationic Carbapenems with Potent anti‐MRSA Activity. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fatigue Life Prediction of Induction Hardened Case Depth Specimens Made From 38MnVS6 Micro Alloyed Steel (2017)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The application of induction hardening treatment plays a vital role for enhancing fatigue life of various automotive components. This will incorporate compressive residual stresses in the component at significant extent. In this paper, wide range of experiments have been carried out on Rotating Bending Fatigue (RBF) specimens made from 38MnVS6 micro alloyed steel with induction hardening up to three different case depths. The set of specimens are fatigue tested at fully reverse loading condition using rotating bending fatigue testing machine. Based on this study a surface treatment factor is evaluated. This surface treatment factor is used as an input for evaluating precise fatigue life of the specimen using FEA packages. The fatigue life evaluated using FEA is showing good agreement with the results obtained through tests on the actual specimens.&lt;/div&gt;&lt;/div&gt;
Reduced Feedback SDMA Based on (2009)

Herein, we treat Space Division Multiple Access (SDMA) based on partial channel state information and limited feedback. We propose a novel framework utilizing subspace packings, where beamforming, feedback, and scheduling are integrated. Advantages of the proposed framework are that the fed back supportable rates are based on the post-scheduling SINR and that the feedback implicitly contains information about the spatial compatibility of the users. The feasibility region of packings of different dimensions is indicated by the allocation outage probability which is derived. Grassmannian subspace packings, DFT-based packings, and non-orthogonal Grassmannian packings are formulated and studied as candi- dates. Numerical simulations show better performance for the proposed scheme compared to conventional channel quantization at the receiver with zero-forcing transmission in i.i.d. Rayleigh fading. Finally, we propose and evaluate a beam-graph method to further reduce the feedback load, that can be used in the context of tracking quantized beamformers.
Low Complexity H.264 Intra MB Coding (2008)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Comparison of manual and semi-automatic registration in augmented reality image-guided liver surgery: a clinical feasibility study (2020)

The technical feasibility of using SmartLiver intraoperatively has been demonstrated. With further improvements semi-automatic registration may enhance user friendliness and workflow of SmartLiver. Manual and semi-automatic registration accuracy were comparable but evaluation on a larger patient cohort is required to confirm these findings.
Vertically Stacked Passive Silicon Photonic Chiplet by µ-Transfer Printing (2023)

We device double-layer stacked silicon photonic MMIs by µ-Transfer Printing. A 900×100-µm 2 -size chiplet consisting of a 220/60-nm-thick silicon core/slab structure is transferred twice onto thermal- and TEOS-SiO 2 under-cladding layers.
Proceedings of the Second Symposium on Molten Carbonate Fuel Cell Technology (1990)

This book contains papers presented at the International Symposium on Carbonate Fuel Cells held at the 178th meeting of the Electrochemical Society in Seattle, WA, October 1990. The development of the MCFC has been rapidly accelerating during the last decade, and MCFC commercialization has become an international goal. As the emphasis of development has been shifting from single-cell testing to stack design and long-term performance, the role of basic research also has broadened. This volume provides an overview of recent advances in the fundamental knowledge base supporting MCFC development and is intended to help define the future directions of research. As the commercialization of the MCFC becomes a reality, issues of manufacturing technology as well as the need to further improve long-term performance will dictate those directions.
Evaluation of growth in irrigated agriculture in the Columbia Plateau, 1975 to 1979 (1980)

During fiscal years 1979, Rockwell Hanford Operations sponsored a project at Pacific Northwest Laboratory to perform a land-cover classification of 41,000 mi/sup 2/ of the Columbia Plateau based on digital Landsat multispectral scanner data from 1975. This initial effort set the stage for a follow-on project, initiated in FY 80, which was to perform a similar analysis of the same area using 1979 Landsat data, with emphasis on determining selected land-cover changes between the years 1975 and 1979. Because of the applicability of these selected land-cover data to regional hydrologic modeling, some support for the study was provided by the PNL Assessment of Geologic Isolation System program. Whereas project time and funding elements permitted only a preliminary land-cover classification, efforts to develop and test a computer program for monitoring land-cover dynamics were successful. Accordingly, project results relative to changes in irrigated cropland between 1975 and 1979 are considered to be accurate within 10%. Brief summaries of the work elements accomplished and associated results are presented.
Iperkalemia cronica nei pazienti cardio – renali: q & a per il cardionefrologo pratico (2019)

Abstract non disponibile (Cardionephrology)
Structural and dynamical studies of hybrid siloxane–silica materials (1997)

Hybrid siloxane–silica coatings have been prepared by hydrolysis and condensation ofN -[3-triethoxysilylpropyl]-2,4-dinitrophenylamine (TSDP) and tetramethoxysilane (TMOS) precursors. Hetero- and homo-condensations between both precursors have been demonstrated to occur in the early stages of the process via 17 O and 29 Si nuclear magnetic resonance (NMR) in solution. These hybrids can be described as nanocomposites made of polysiloxane-based domains cross-linked by silica-based nanoparticles, as evidenced by solid-state NMR, differential scanning calorimetry (DSC) and Fourier-transform infrared (FTIR) studies. Moreover, the high degree of interpenetration occurring in these materials is evidenced by the presence of some Q and T subunits sequestered within these polysiloxane and silica-based domains, respectively. The high-resolution solid-state 13 C NMR technique has shown that the mobility of the propyl 2,4-dinitrophenylamine chromophores is correlated with the glass-transition phenomenon of the matrix.
Slide navigation patterns among pathologists with long experience of digital review (2014)

The new navigation possibilities in the digital workstation were used to a large extent. The division of actions into different concepts can be used to find and prioritize between existing user interface designs as well as to understand the different navigation styles used by different pathologists.