gebhart/patrepeval huggingface dataset:
A Study of Deep Neural Networks Transfer Learning For Fault Diagnosis Applications (2021)

Intelligent fault diagnosis utilizing deep learning algorithms has been widely investigated recently. Although previous results demonstrated excellent performance, features learned by Deep Neural Networks (DNN) are part of a large black box. Consequently, lack of understanding of underlying physical meanings embedded within the features can lead to poor performance when applied to different but related datasets i.e. transfer learning applications. This study will investigate the transfer learning performance of a Convolution Neural Network (CNN) considering 4 different operating conditions. Utilizing the Case Western Reserve University (CWRU) bearing dataset, the CNN will be trained to classify 12 classes. Each class represents a unique differentfault scenario with varying severity i.e. inner race fault of 0.007”, 0.014” diameter. Initially, zero load data will be utilized for model training and the model will be tuned until testing accuracy above 99% is obtained. The model performance will be evaluated by feeding vibration data collected when the load is varied to 1, 2 and 3 HP. Initial results indicated that the classification accuracy will degrade substantially. Hence, this paper will visualize convolution kernels in time and frequency domains and will investigate the influence of changing loads on fault characteristics, network classification mechanism and activation strength.
High-dynamic-range, low-noise analog optical links using external modulators: analysis and demonstration (1991)

Analog fiber-optic links using an integrated-optical intensity modulator have been demonstrated. These links operate at frequencies from 50 MHz to 22 GHz with electrical gain u to 1 1 dB noise figure as low as 6 dB and intermodulation-free dynamic range of up to 1 13 dBHz2/3. The design factors determining optical link performance are discussed briefly and the effect of adding electronic amplifiers is analyzed. SUMMARY Analog optical links are attractive for many applications ranging from cable television distribution to radar-signal transmission at microwave frequencies. These systems often require a link with a low noise figure low electrical insertion loss and high dynamic range. We have demonstrated several intensitymodulated optical links that use a diode-pumped Nd:YAG laser and an integrated-optical modulator to achieve high performance by all these measures. 13 We will first discuss these experimental links and then show how their performance could be improved further by adding electronic amplifiers. Figure 1 illustrates the optical link used in our experiments with an electronic preamplifier and postamplifier added. (The experimental results reported here refer to the electrical ports of the optical link Figure 1. Block diagram of the optical link with an electronic preamplifier (Al) and postamplifier (A3) added. (Experimental results in the paper refer to the optical link alone without the amplifiers. ) 252 / SPIE Vol 1371 High-Frequency Analog Fiber Optic Systems(1990) OPTICAL LINK 161 884-1 INTEGRATED-OPTICAL PIN
Incorporation of uridine- 3 H and sodium acetate- 14 C in lymphocytes derived from normal and leukemic individuals. (1972)

Patterns of isotope incorporation indicative of histone acetylation and RNA synthesis were studied in lymphocytes derived from patients with chronic and acute lymphoblastic leukemia and were compared to normal controls. Cultures with and without phytohemagglutinin stimulation were investigated. Statistically significant differences were observed between cultures of the leukemic patients and normal individuals but not between the two types of leukemia. Cells from leukemic patients incorporated both sodium acetate-14C and uridine-3H without phytohemagglutinin stimulation (“spontaneous”), while normal lymphocytes required the addition of phytohemagglutinin. This technique may prove useful in predicting the hematological relapse of leukemic patients currently in remission.
A genome-wide case-only test for the detection of digenic inheritance in human exomes (2020)

Significance Despite a growing number of reports of rare disorders not fully explained by monogenic lesions, digenic inheritance has been reported for only 54 diseases to date. The very few existing methods for detecting gene × gene interactions from next-generation sequencing data were generally examined in rare-variant association studies with limited simulation analyses for short genomic regions, under a case-control design. We describe a case-only approach designed specifically to search for digenic inheritance, which avoids recruitment of controls. We show, through both extensive simulation studies on real whole-exome sequencing datasets and application to a real example of craniosynostosis, that our method is robust and powerful for the genome-wide identification of digenic lesions.
Image quality evaluation of motion-contaminated calcified plaques in cardiac CT (2007)

An automated method for evaluating the image quality of motion-contaminated calcified plaques in non contrast-enhanced cardiac CT was developed. This method consisted of using the rapid phase-correlated ROI (RP-ROI) reconstruction algorithm for generating a 4D series of calcified plaque images, and then extracting phase-correlated dynamic, morphological, and intensity-based features of the plaques. Velocity-based linear regression (VLR), multiple linear regression (MLR), and artificial neural network (ANN) regression models were used to predict plaque motion indices based on these extracted features. Since motion indices were reflective of the amount of motion that plaques underwent at multiple phases throughout the cardiac cycle, these indices represented metrics of image quality with respect to motion artifacts. Motion indices were predicted for sixty calcified plaques placed along the left and right coronary arterial trees in the dynamic NCAT phantom. In a five-fold cross-validation scheme involving independent testing groups of twelve plaques, average repeated measures concordance correlation coefficients for the VLR, MLR, and ANN models were 0.848 ± 0.022, 0.885 ± 0.014, and 0.950 ± 0.009. The motion indices predicted by the ANN regression model also were used to obtain optimal phases for image interpretation of individual plaques.
Synthesis of Electron-Rich CNN-Pincer Complexes, with N-Heterocyclic Carbene and (S)-Proline Moieties and Application to Asymmetric Hydrogenation (2009)

New chiral CNN-pincer-type gold, palladium, and rhodium complexes containing N-heterocyclic carbene substituent and (S)-N-tert-butyl-methylpyrrolidine-2-carboxamide as chiral auxiliary have been synthesized and studied for asymmetric hydrogenation. The complexes were prepared by the silver carbene transfer route from the respective silver complex. The reaction with [RhCl(cod)]2 (cod = cycloocta-1,5-diene), PdCl2(CH3CN)2, or K[AuCl4] affords the corresponding cationic [Rh(cod)(ligand)]Cl, [PdCl(ligand)]Cl, and [AuCl(ligand)]Cl2 complexes in which the ligand functions effectively in a CNN coordination mode. The complexes catalyze the enantioselective hydrogenation of prochiral alkenes. Enantioselectivity is very sensitive to the NHC N-substituent, resulting in a useful switch in the predominant enantiomer.
Can hematology reference intervals be derived from hospitalized patients' data? (1995)

Journal Article Can hematology reference intervals be derived from hospitalized patients' data? Get access G S Cembrowski, G S Cembrowski Search for other works by this author on: Oxford Academic Google Scholar V F Fairbanks V F Fairbanks Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 41, Issue 7, 1 July 1995, Pages 1048–1050, https://doi.org/10.1093/clinchem/41.7.1048 Published: 01 July 1995
Fast Transformation-Invariant Factor Analysis (2002)

Dimensionality reduction techniques such as principal component analysis and factor analysis are used to discover a linear mapping between high dimensional data samples and points in a lower dimensional subspace. In [6], Jojic and Frey introduced mixture of transformation-invariant component analyzers (MTCA) that can account for global transformations such as translations and rotations, perform clustering and learn local appearance deformations by dimensionality reduction. However, due to enormous computational requirements of the EM algorithm for learning the O(¤ model, ) ¤ where is the dimensionality of a data sample, MTCA was not practical for most applications. In this paper, we demonstrate how fast Fourier transforms can reduce the computation to the order ¤ log ¤ of. With this speedup, we show the effectiveness of MTCA in various applications- tracking, video textures, clustering video sequences, object recognition, and object detection in images. 1
n -scroll chaos generator using nonlinear transconductor (2002)

A novel chaotic oscillator capable of generating n-scroll chaos by relying on a multiple-cycle nonlinear transconductor is reported. The function of this nonlinearity can be mathematically represented via smooth hyperbolic tangent functions and its implementation only requires properly-biased bipolar differential-pair cells. The structure of the proposed oscillator is much simpler than existing n-scroll chaos generators.
Investigating Heater Resistance Tolerance of the Heat-Pulse Sensor for Accurate Soil Moisture Measurements on Vadose Zone Soil (2021)

Integrated precise irrigation management is one of the efficient methods to improve the crop productivity and also helps in water conservation where soil moisture sensors are widely used. Out of available soil-moisture sensors, the dual-probe heat-pulse (DPHP) sensor is the potential candidate due to its optimum price and better accuracy. A DPHP sensor has the heater probe kept at a distance from the temperature sensor probe. Heater probe consist of nichrome wire as the heating element, which is embedded in the stainless-steel tube. In this paper, we examine the acceptable tolerance in the heater resistance across 25 DPHP sensors, for the accurate soil moisture measurement. For this purpose, we used in-house developed 25 DPHP sensors where heater resistance is about 56 <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\Omega$</tex> with <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\pm$</tex> 5% tolerance. Under laboratory condition, we observed that difference in the measured volumetric water content (VWC) is within <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\pm$</tex> 3 % (VWC) when compared with standard gravimetric method. For the field measurements, we developed the automated-self sustained system and deployed 3 systems on the rooftop of the building. Under field conditions, we observed that difference in the measured VWC from the 3 systems is within <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\pm$</tex> 3 % (VWC) when benchmarked with standard gravimetric method.
The practical use of genome sequencing data in the management of a feline colony pedigree (2017)

The use of WGS of a small sampling among a large feline colony has enabled us to identify possible disease-causing variants, their genotype state and measure pedigree management of genetic diversity. We contend a limited but strategic sampling of feline colony individuals using WGS can inform veterinarians of future health anomalies and guide breeding practices to ensure healthy genetic diversity.
Lisp extensions for multiprocessing (2003)

Extensions to Common Lisp for concurrent computation on multiprocessors are discussed. Functions for process creation, communication, and synchronization are described. Process objects create multiple threads of control. Processes are lightweight so that programmers can use them to take advantage of fine-grained parallelism. Communication and synchronization are managed with mailboxes. Signals allow processes to communicate using asynchronous interrupts. These constructs are used to implement several higher-level multiprocessing abstractions. These include structured processes, a parallel tree search, and dataflow computation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Crystal structure of human IRAK1 (2017)

Interleukin 1 (IL-1) receptor-associated kinases (IRAKs) are serine/threonine kinases that play critical roles in initiating innate immune responses against foreign pathogens and other types of dangers through their role in Toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) mediated signaling pathways. Upon ligand binding, TLRs and IL-1Rs recruit adaptor proteins, such as myeloid differentiation primary response gene 88 (MyD88), to the membrane, which in turn recruit IRAKs via the death domains in these proteins to form the Myddosome complex, leading to IRAK kinase activation. Despite their biological and clinical significance, only the IRAK4 kinase domain structure has been determined among the four IRAK family members. Here, we report the crystal structure of the human IRAK1 kinase domain in complex with a small molecule inhibitor. The structure reveals both similarities and differences between IRAK1 and IRAK4 and is suggestive of approaches to develop IRAK1- or IRAK4-specific inhibitors for potential therapeutic applications. While the IRAK4 kinase domain is capable of homodimerization in the unphosphorylated state, we found that the IRAK1 kinase domain is constitutively monomeric regardless of its phosphorylation state. Additionally, the IRAK1 kinase domain forms heterodimers with the phosphorylated, but not unphosphorylated, IRAK4 kinase domain. Collectively, these data indicate a two-step kinase activation process in which the IRAK4 kinase domain first homodimerizes in the Myddosome, leading to its <i>trans</i>-autophosphorylation and activation. The phosphorylated IRAK4 kinase domain then forms heterodimers with the IRAK1 kinase domain within the Myddosome, leading to its subsequent phosphorylation and activation.
Flexible Hybrid Semiconductors with Low Thermal Conductivity: The Role of Organic Diamines (2009)

Flexible conductors: A unique type of organic–inorganic hybrid semiconductor crystals have been synthesized that are flexible and have low thermal conductivity. The hybrids consist of ZnTe layers connected by various diamines (see picture for examples; C gray, N blue, Te red, Zn large pale blue spheres).
Molecular Characterization of Polygalacturonases as Grass Pollen-Specific Marker Allergens: Expulsion from Pollen via Submicronic Respirable Particles (2004)

Grass pollen belong to the most important allergen sources involved in the elicitation of allergic asthma. We have isolated cDNAs coding for Bermuda grass (Cynodon dactylon) and timothy grass (Phleum pratense) pollen allergens, belonging to a family of pectin-degrading enzymes (i.e., polygalacturonases). The corresponding allergens, termed Cyn d 13 and Phl p 13, represent glycoproteins of approximately 42 kDa and isoelectric points of 7.5. rPhl p 13 was expressed in Escherichia coli and purified to homogeneity. Immunogold electron microscopy using rabbit anti-rPhl p 13 Abs demonstrated that in dry pollen group 13, allergens represent primarily intracellular proteins, whereas exposure of pollen to rainwater caused a massive release of cytoplasmic material containing submicronic particles of respirable size, which were coated with group 13 allergens. The latter may explain respiratory sensitization to group 13 allergens and represents a possible pathomechanism in the induction of asthma attacks after heavy rainfalls. rPhl p 13 was recognized by 36% of grass pollen allergic patients, showed IgE binding capacity comparable to natural Phl p 13, and induced specific and dose-dependent basophil histamine release. Epitope mapping studies localized major IgE epitopes to the C terminus of the molecule outside the highly conserved functional polygalacturonase domains. The latter result explains why rPhl p 13 contains grass pollen-specific IgE epitopes and may be used to diagnose genuine sensitization to grass pollen. Our finding that rabbit anti-rPhl p 13 Abs blocked patients' IgE binding to the allergen suggests that rPhl p 13 may be used for immunotherapy of sensitized patients.
ASSET (1994)

Extended transaction models in databases were motivated by the needs of complex applications such as CAD and software engineering. Transactions in such applications have diverse needs, for example, they may be long lived and they may need to cooperate. We describe ASSET, a system for supporting extended transactions. ASSET consists of a set of transaction primitives that allow users to define custom transaction semantics to match the needs of specific applications. We show how the transaction primitives can be used to specify a variety of transaction models, including nested transactions, split transactions, and sagas. Application-specific transaction models with relaxed correctness criteria, and computations involving workflows, can also be specified using the primitives. We describe the implementation of the ASSET primitives in the context of the Ode database.
Optical Spectroscopy of Electronic States in a Single Pair of Vertically Coupled Self-Assembled Quantum Dots (2001)

Artificial molecules are studied using coupled quantum-dot (QD) ensembles and single QD spectroscopy. We demonstrate a significant improvement in the uniformity of the macroscopic ensembles of vertically self-aligned stacked QDs. The coupling strength between the zero-dimensional states is varied by changing the distance between two layers of stacked self-assembled InAs/GaAs QDs. For strongly coupled QDs grown with a 4 nm spacer layer, state filling spectroscopy reveals a shift of the QD symmetric state to lower energies by ∼23 meV. The wetting layer states are also strongly coupled because of their shallower confinement. Spectra of single pairs of coupled QDs are compared to those of single QDs. Energy level splittings larger than 30 meV of the symmetric and antisymmetric states of the lowest confined shell are measured and compared with theory.
In vivo killing of primary HIV-infected cells by peripheral-injected early memory–enriched anti-HIV duoCAR T cells (2022)

HIV-specific chimeric antigen receptor-T cell (CAR T cell) therapies are candidates to functionally cure HIV infection in people with HIV (PWH) by eliminating reactivated HIV-infected cells derived from latently infected cells within the HIV reservoir. Paramount to translating such therapeutic candidates successfully into the clinic will require anti-HIV CAR T cells to localize to lymphoid tissues in the body and eliminate reactivated HIV-infected cells such as CD4+ T cells and monocytes/macrophages. Here we show that i.v. injected anti-HIV duoCAR T cells, generated using a clinical-grade anti-HIV duoCAR lentiviral vector, localized to the site of active HIV infection in the spleen of humanized mice and eliminated HIV-infected PBMCs. CyTOF analysis of preinfusion duoCAR T cells revealed an early memory phenotype composed predominantly of CCR7+ stem cell-like/central memory T cells (TSCM/TCM) with expression of some effector-like molecules. In addition, we show that anti-HIV duoCAR T cells effectively sense and kill HIV-infected CD4+ T cells and monocytes/macrophages. Furthermore, we demonstrate efficient genetic modification of T cells from PWH on suppressive ART into anti-HIV duoCAR T cells that subsequently kill autologous PBMCs superinfected with HIV. These studies support the safety and efficacy of anti-HIV duoCAR T cell therapy in our presently open phase I/IIa clinical trial (NCT04648046).
Pancreaticoduodenectomy (1996)

Pancreaticoduodenectomy can be performed with a similar perioperative morbidity and mortality and only a minimal increase in hospital stay when compared with traditional surgical palliation. Pancreaticoduodenectomy with postoperative chemotherapy and radiation therapy is associated with improved long-term survival when compared with patients treated with surgical bypass. These data support the role of palliative pancreaticoduodenectomy in patients with pancreatic carcinoma and with local residual disease.
Low-temperature synthesis of 2D MoS2on a plastic substrate for a flexible gas sensor (2018)

The efficient synthesis of two-dimensional molybdenum disulfide (2D MoS2) at low temperatures is essential for use in flexible devices. In this study, 2D MoS2 was grown directly at a low temperature of 200 °C on both hard (SiO2) and soft substrates (polyimide (PI)) using chemical vapor deposition (CVD) with Mo(CO)6 and H2S. We investigated the effect of the growth temperature and Mo concentration on the layered growth by Raman spectroscopy and microscopy. 2D MoS2 was grown by using low Mo concentration at a low temperature. Through optical microscopy, Raman spectroscopy, X-ray photoemission spectroscopy, photoluminescence, and transmission electron microscopy measurements, MoS2 produced by low-temperature CVD was determined to possess a layered structure with good uniformity, stoichiometry, and a controllable number of layers. Furthermore, we demonstrated the realization of a 2D MoS2-based flexible gas sensor on a PI substrate without any transfer processes, with competitive sensor performance and mechanical durability at room temperature. This fabrication process has potential for burgeoning flexible and wearable nanotechnology applications.
Secure Enablement of Real Time Applications: A Novel End-to-End Approach (2012)

The Internet has evolved into a multi-service Internet Protocol (IP) network with support for various types of traffic, including multimedia. Given the relatively open nature of IP networks, securely enabling multimedia services is increasingly important. While protocols such as Secure Real Time Protocol (SRTP) provide container formats for various applications, the supporting security solutions lack end-to-end secure key management. In this paper, we propose a novel secure key management framework targeted for real time applications in multi-operator environments. In particular, by leveraging an Identity-Based Authenticated Key Exchange (IBAKE) protocol, we develop secure key management solutions to support two-party communications, conferencing applications, call forking, call redirect, and deferred delivery. Our framework eliminates the need for costly public key infrastructure (PKI) or other online solutions, overcomes the problem of key escrow while providing perfect forward and backwards secrecy, and works across applications and media types. Overall, our solution opens-up new lines of research and business opportunities in secure application enablement. © 2012 Alcatel-Lucent.
Hybrid Constructs for Tridimensional Correction of the Thoracic Spine in Adolescent Idiopathic Scoliosis (2010)

Although both of these hybrid constructs efficaciously corrected the coronal and axial deformities in AIS, the results of the UC technique were superior to those achieved with hooks in all 3 planes, especially the sagittal plane. Moreover, the UC technique is straightforward and safe, reducing both operative duration and blood loss.
In-vivo Characterization of Her-2/neu carcinogenesis in Mice Using Fluorescence Molecular Tomography (2006)

We reconstruct different bio-markers in Her-2/neu mice using Fluorescence Molecular Tomography (FMT) and appropriate fluorescent probe strategies. Protease up-regulation can serve as a generic detection marker whereas more specific antibody based imaging can be employed for higher specificity and more sensitive detection.