gebhart/patrepeval huggingface dataset:
Metabolic and crystal arthropathies: 112. Rapid Improvement in Health-Related Quality of Life in Gouty Arthritis Patients Treated with Canakinumab (ACZ885) Compared to Triamcinolone Acetonide (2011)

Background: Canakinumab, a fully human anti-IL-1β antibody has been shown to control inflammation in gouty arthritis. This study evaluated changes in health-related quality of life (HRQoL) in patients treated with canakinumab or triamcinolone acetonide (TA). Methods: An 8-wk, dose-ranging, active controlled, single-blind study in patients (≥18 to ≤80 years) with acute gouty arthritis flare, refractory to or contraindicated to NSAlDs and/or colchicine, were randomized to canakinumab 10, 25, 50, 90, 150 mg sc or TA 40 mg im. HRQoL was assessed using patient reported outcomes evaluating PCS and MCS, and subscale scores of SF-36® [acute version 2]) and functional disability (HAQ-DI©). Results: In canakinumab 150 mg group, the most severe impairment at baseline was reported for physical functioning and bodily pain; levels of 41.5 and 36.0, respectively, which improved in 7 days to 80.0 and 72.2 (mean increases of 39.0 and 35.6) and at 8 wks improved to 86.1 and 86.6 (mean increases of 44.6 and 50.6); these were higher than levels seen in the general US population. TA group, showed less improvement in 7 days (mean increases of 23.3 and 21.3 for physical function and bodily pain). Functional disability scores, measured by the HAQ-DI© decreased in both treatment groups (Table 1). Conclusions: Gouty arthritis patients treated with canakinumab showed a rapid improvement in physical and mental well-being based on SF-36® scores. In contrast to the TA group, patients treated with canakinumab showed improvement in 7 days in physical function and bodily pain approaching levels of the general population. Disclosure statement: U.A., A.F., V.M., D.R., P.S. and K.S. are employees and shareholders of Novartis Pharma AG. A.P. has received research support from Novartis Pharma AG. N.S. has received research support and consultancy fees from Novartis Pharmaceuticals Corporation, has served on advisory boards for Novartis, Takeda, Savient, URL Pharma and EnzymeRx, and is/has been a member of a speakers’ bureau for Takeda. A.S. has received consultation fees from Novartis Pharma AG, Abbott, Bristol-Myers Squibb, Essex, Pfizer, MSD, Roche, UCB and Wyeth. All other authors have declared no conflicts of interest.
Scalability of non-intrusive load monitoring for shipboard applications (2009)

The non-intrusive load monitor has been demonstrated as an effective tool for evaluating and monitoring shipboard electro-mechanical systems through analysis of electrical power data. A key advantage of the non-intrusive approach is the ability to reduce sensor count by monitoring collections of loads. This paper reviews trade-offs that affect the likely performance of the NILM in a real world environment.
Self-Aligned Silicon Interposer Tiles and Silicon Bridges Using Positive Self-Alignment Structures and Rematable Mechanically Flexible Interconnects (2014)

A novel large-scale silicon system platform is proposed and demonstrated. In this paper, three silicon interposer tiles are aligned and mounted on a printed wiring board (PWB), and two silicon bridges are aligned and mounted on top of the three interposer tiles; each silicon bridge spans two interposer tiles. Four positive self-alignment structures and four inverted pyramid pits self-align a tile to the PWB and a bridge to two tiles. Mechanically flexible interconnects (MFI) form nonbonding electrical connections between the three interposer tiles and two silicon bridges; MFIs are fabricated on the interposer tiles. Pointy tips on the MFIs form low contact resistance with the pads on the silicon bridges. Less than 4 μm alignment error is demonstrated on a stack of silicon substrates, and <;8μm alignment error between a silicon bridge and tiles is also demonstrated on a FR4 substrate. Daisy chain and four-point measurements are performed to verify electrical connections between the three interposer tiles via MFIs and silicon bridges.
Isolation and characterization of anti‐HIV peptides from Dorstenia contrajerva and Treculia obovoidea (2004)

Using a high throughput screen based on the interaction of the HIV-1 gp41 ectodomain with the virucidal protein cyanovirin-N (CV-N), we isolated two new peptides which inhibited the binding of CV-N to gp41 and which subsequently showed anti-HIV activity in a whole cell assay. A 5-kDa (contrajervin) and 10 kDa (treculavirin) peptide were isolated from Dorstenia contrajerva and Treculia obovoidea, respectively. Treculavirin was composed of two subunits, each containing 50 amino acid residues, which are covalently linked by at least one disulfide bond between the subunits. Both peptides were shown to bind to gp41 and gp120 and to inhibit the cytopathic effects of HIV-1(RF) infection in a human T-lymphoblastoid cell line (CEM-SS).
Reliability tests on micro-insert die bonding technology (2012)

Micro-insert technology is a wafer level stacking technology offering main advantages such as simplicity, low cost and compatibility with chip assembly technologies. This paper presents recent preliminary reliability tests results. Thermal cycling tests between -40°C and 125°C and damp heat tests at 85%RH/85°C are performed, tests results show that micro-insert technology is very robust. A interesting correlation is found between initial interconnection electrical resistance and time to failure during damp heat test, allowing die sorting for reliability.
Investigation of the current resolution limits of advanced extreme ultraviolet (EUV) resists (2006)

The past two years has brought tremendous improvements in the crucial area of resists for extreme ultraviolet (EUV) lithography. Nested and isolated line resolutions approaching 30 nm and 25 nm, respectively, have been demonstrated. These advances have been enabled, in large part, by the high-numerical (0.3) EUV imaging capabilities provided by the Berkeley microfield exposure tool (MET). Here we investigate the resolution limits in several advanced EUV resists using the Berkeley MET. Comparisons to aerial-image performance and the use of resolution-enhancing illumination conditions are used to establish the fact that the observed pattern resolution in the best chemically-amplified resists available today are indeed resist limited. Moreover, contrast transfer function (CTF) techniques are used to directly compare various advanced resists. Strong correlation is observed between relative CTF performance and observed resolution limits.
Modelling-Resistant Physical Unclonable Functions. (2014)

Abstract not provided.
Interwoven Spiral Array (ISPA) With a 10:1 Bandwidth on a Ground Plane (2010)

We describe a novel, planar, circularly polarized (CP), interwoven spiral array (ISPA) having a 10:1 bandwidth while operating conformally on a perfect electric conducting (PEC) ground plane. The array is comprised of rectangular, self-complementary spirals. However, unlike typical array designs, the elements have their arms "interwoven" to enhance coupling. This coupling serves to mitigate the inductive effects contributed by the PEC ground plane. Consequently, the unit cell of the array encompasses several adjacent array elements. This feature leads to unique array properties, and in this letter, we pursue a numerical analysis and design of an array version that delivers a 10:1 bandwidth, for a broadside scan, in a conformal setting.
Topical hypochlorous acid (HOCl) blocks inflammatory gene expression and tumorigenic progression in UV-exposed SKH-1 high risk mouse skin (2021)

Hypochlorous acid (HOCl) is the active oxidizing principle underlying drinking water disinfection, also delivered by numerous skin disinfectants and released by standard swimming pool chemicals used on a global scale, a topic of particular relevance in the context of the ongoing COVID-19 pandemic. However, the cutaneous consequences of human exposure to HOCl remain largely unknown, posing a major public health concern. Here, for the first time, we have profiled the HOCl-induced stress response in reconstructed human epidermis and SKH-1 hairless mouse skin. In addition, we have investigated the molecular consequences of solar simulated ultraviolet (UV) radiation and HOCl combinations, a procedure mimicking co-exposure experienced for example by recreational swimmers exposed to both HOCl (pool disinfectant) and UV (solar radiation). First, gene expression elicited by acute topical HOCl exposure was profiled in organotypic human reconstructed epidermis. Next, co-exposure studies (combining topical HOCl and UV) performed in SKH-1 hairless mouse skin revealed that the HOCl-induced cutaneous stress response blocks redox and inflammatory gene expression elicited by subsequent acute UV exposure (Nos2, Ptgs2, Hmox1, Srxn1), a finding consistent with emerging clinical evidence in support of a therapeutic role of topical HOCl formulations for the suppression of inflammatory skin conditions (e.g. atopic dermatitis, psoriasis). Likewise, in AP-1 transgenic SKH-1 luciferase-reporter mice, topical HOCl suppressed UV-induced inflammatory signaling assessed by bioluminescent imaging and gene expression analysis. In the SKH-1 high-risk mouse model of UV-induced human keratinocytic skin cancer, topical HOCl blocked tumorigenic progression and inflammatory gene expression (Ptgs2, Il19, Tlr4), confirmed by immunohistochemical analysis including 3-chloro-tyrosine-epitopes. These data illuminate the molecular consequences of HOCl-exposure in cutaneous organotypic and murine models assessing inflammatory gene expression and modulation of UV-induced carcinogenesis. If translatable to human skin these observations provide novel insights on molecular consequences of chlorination stress relevant to environmental exposure and therapeutic intervention.
Miscellaneous Capabilities Negotiation in the Session Description Protocol (SDP) (2013)

The Session Description Protocol (SDP) has been extended with a capability negotiation mechanism framework that allows the endpoints to negotiate transport protocols and attributes. This framework has been extended with a media capabilities negotiation mechanism that allows endpoints to negotiate additional media-related capabilities. This negotiation is embedded into the widely used SDP offer/answer procedures.
Synthesis of Pentazocine (1974)

l u t i d i n e (a) A r c h e r a n d c o -w o r k e r s ' method ( b ) Kametani a n d c o -w o r k e r s ' method ( c ) Sumitomokagaku' s method 2-2 F r o m 1 -amino-3-methyl-3-pentene ( a ) Mannich r e a c t i o n (b) B i s c h l e r -N a p i e r a l s k i r e a c t i o n 2-3 F r o m a n amino a c i d 2-4 T h e i n t r o d u c t i o n of 3-methyl-2-butenyl g r o u p to t h e 1 , 2 , 3,4,5,6-hexahydro-2,6-methano-3-benzazocine n u c l e u s(a) Debenzylation of q u a t e r n a r y ammonium s a l t by c a t a l y t i c hydrogenation (b) Debenzylation of q u a t e r n a r y ammonium s a l t by thio- phenoxide anion ( c ) Hofmann degradation of q u a t e r n a r y ammonium s a l t s (d) Acylation of N-methyl d e r i v a t i v e and reduction 3. S t e r e o c h e m i s t r y of pentazocine and i t s intermediate 3 1 Optical resolution of pentazocine 3-2 Configuration of intermediates 4. Conclusion
Microstructure and properties in friction stir weld of 12Cr steel (2013)

Friction stir welding was employed for joining of 12Cr heat resistant ferritic steel. Microstructure and mechanical properties in the obtained welds were examined and their relationship was established. The stir zone microstructure was found to consist of quenched martensite with numerous fine dispersoids uniformly distributed in grain interiors. The formation of this microstructure remarkably strengthened the stir zone. Tempering for 3·6 ks at 923 K reduced the as welded hardness of friction stir weld to nearly base material level.
Energy efficient photonic millimeter-wave generation using cascaded polarization modulators (2018)

A filter-less millimeter-wave generation scheme consisting of four polarization modulators in series, each followed by a polarizer is proposed to achieve optoelectronic frequency octupling. Theoretical analysis of the architecture is done by a transfer function method, validated by industry-standard software simulation. The circuit shows high potential in achieving desired performance with lower input RF power when compared to the another configuration. Effects of imbalances in the key circuit parameters are also investigated.
OLTP on Hardware Islands (2012)

Modern hardware is abundantly parallel and increasingly heterogeneous. The numerous processing cores have non-uniform access latencies to the main memory and to the processor caches, which causes variability in the communication costs. Unfortunately, database systems mostly assume that all processing cores are the same and that microarchitecture differences are not significant enough to appear in critical database execution paths. As we demonstrate in this paper, however, hardware heterogeneity does appear in the critical path and conventional database architectures achieve suboptimal and even worse, unpredictable performance. We perform a detailed performance analysis of OLTP deployments in servers with multiple cores per CPU (multicore) and multiple CPUs per server (multisocket). We compare different database deployment strategies where we vary the number and size of independent database instances running on a single server, from a single shared-everything instance to fine-grained shared-nothing configurations. We quantify the impact of non-uniform hardware on various deployments by (a) examining how efficiently each deployment uses the available hardware resources and (b) measuring the impact of distributed transactions and skewed requests on different workloads. Finally, we argue in favor of shared-nothing deployments that are topology- and workload-aware and take advantage of fast on-chip communication between islands of cores on the same socket.
Joint Beam-Hopping Scheduling and Power Allocation in NOMA-Assisted Satellite Systems (2021)

In this paper, we investigate potential synergies of non-orthogonal multiple access (NOMA) and beam hopping (BH) for multi-beam satellite systems. The coexistence of BH and NOMA provides time-power-domain flexibilities in mitigating a practical mismatch effect between offered capacity and requested traffic per beam. We formulate the joint BH scheduling and NOMA-based power allocation problem as mixed-integer non-convex programming. We reveal the exponential-conic structure for the original problem, and reformulate the problem to the format of mixed-integer conic programming (MICP), where the optimum can be obtained by exponential-complexity algorithms. A greedy scheme is proposed to solve the problem on a timeslot-by-timeslot basis with polynomial-time complexity. Numerical results show the effectiveness of the proposed efficient suboptimal algorithm in reducing the matching error by 62.57% in average over the OMA scheme and achieving a good trade-off between computational complexity and performance compared to the optimal solution.
X-ray photoemission investigations of binary and ternaryC60fullerides of Na, K, Rb, and Cs (1993)

Core-level photoemission studies of alkali fulleride ${\mathit{A}}_{\mathit{x}}$${\mathrm{C}}_{60}$ thin films indicate alkali bonding configurations that can be associated with octahedral and tetrahedral interstitial sites of the ${\mathrm{C}}_{60}$ lattice. For ${\mathrm{K}}_{\mathit{x}}$${\mathrm{C}}_{60}$, the K 2p core-level results suggest ${\mathrm{K}}_{3}$${\mathrm{C}}_{60}$ nucleation for K concentration as low as x\ensuremath{\sim}0.1 with occupation of both octahedral and tetrahedral sites. In contrast, the Rb 3d and Cs 4d core-level spectra show filling of only octahedral sites until x\ensuremath{\sim}1, forming ${\mathit{A}}_{1}$${\mathrm{C}}_{60}$ phases. For intercalation beyond x\ensuremath{\sim}1, the fcc tetrahedral sites of Rb are occupied as ${\mathrm{Rb}}_{3}$${\mathrm{C}}_{60}$ forms. Intercalation with K or Rb beyond x\ensuremath{\sim}3, or with Cs beyond x\ensuremath{\sim}1, results in a spectral feature that is consistent with formation of a body-centered phase with equivalent tetrahedral interstitial sites. Results for ${\mathrm{Na}}_{\mathit{x}}$${\mathrm{C}}_{60}$ suggest that Na ions occupy off-center positions in the large octahedral sites. Studies of ternary fullerides ${\mathrm{K}}_{\mathit{x}}$${\mathit{A}}_{\mathit{y}}$${\mathrm{C}}_{60}$ (x+y3) demonstrate preferential filling of the octahedral sites by the larger ion.
ChemInform Abstract: Combinatorial Synthesis and Multi‐Dimensional NMR Spectroscopy ‐ An Understanding of Protein‐Ligand Interactions (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Experiments Using an Antenna Array in a Mobile Communications Environment (2005)

The goal of this paper is to obtain knowledge about spatial characteristics of the mobile channel seen through an antenna array. Particular interest is paid to the effect of local scattering. i.e large number of rays in the vicinity of the mobile.
Wyner-Ziv to H.264 video transcoder for low cost video encoding (2009)

This paper proposes a Wyner-Ziv/H.264 transcoder that enables low cost video applications. The proposed solution supports video encoding on resource constrained devices such as disposable video cameras, network camcorders and low cost video encoders. This approach is based on reducing encoding resource requirements on a device by using Wyner-Ziv video encoding. The system shifts the burden of complexity away from the encoder, for example to a network node, where a transcoder efficiently converts WZ encoded video to H.264 by reusing the information from the WZ decoding stage. The transcoded H.264 video is requires fewer resources than WZ decoding and therefore reduces the complexity of decoding. The complexity of encoding and playback ends of video applications is thus reduced enabling new class of consumer application. The paper is focused on reducing the complexity of the macro-block mode coding decision process carried out in H.264 encoding stage of the transcoder. Based on a data mining process, the approach replaces the high complexity H.264 mode decision algorithm by a faster decision tree. The proposed architecture reduces the battery consumption of the end-user devices and the transcoding time is reduced by 86% with negligible rate-distortion loss.
Silicon Nanowire Solar Cells: Device Physics, Fabrication, and Optoelectronic Properties (2008)

The use of silicon nanowire arrays in novel photovoltaic device geometries are described. We first discuss the optical properties of silicon nanowire arrays and show that they are excellent omni-directional anti-reflective structures, as well as provide strong light trapping. We then discuss the expected efficiency from such devices and the associated device physics. This is followed by a description of the process flow in making silicon nanowire-based solar cells, and finally we show device performance data. Devices fabricated on degenerately doped silicon test substrates showed efficiencies as high as 1.2%, whereas devices on stainless steel foil demonstrated an efficiency on the order of ~ 0.1%. In both cases the short-circuit current densities obtained were in the mA/cm2 range, and broad external quantum efficiency curves were measured. Devices formed using a galvanic wet etching process on bulk Si wafers showed a maximum efficiency of ~1.3%, with losses attributed to front-surface recombination in the nanowire array. Technical challenges in further improving performance are discussed in detail.
Challenges in Elucidating the Genetics of Diabetic Retinopathy (2013)

The field of DR genetics is still in its infancy and is a challenge because of the complexity of the disease. This review outlines some strategies and lessons for future investigation to improve our understanding of this complex genetic disorder.
MRAM: from STT to SOT, for security and memory (2018)

Spin Transfer Torque Magnetic Random Access Memory (STT-MRAM) is one of the leading candidates for embedded memory convergence in advanced technology nodes. It is particularly adapted to low-power applications, requiring a decent level of performance. However, it also have interests for secured applications. The PRESENT cipher is a lightweight cryptographic algorithm targeting ultra-low power applications such as the Internet of Things or RFID. This paper aims to combine this low power cryptographic algorithm with the STT-MRAM which main feature is its low consumption. This new generation of ciphers is very interesting for normally-off applications. Actually, for these specific applications hybrid CMOS/STT-MRAM ciphers consume less power than pure CMOS cryptographic algorithms. Although the performance of STT-MRAM is much better than standard non-volatile technologies like flash, it suffers from limitations for high-speed applications. A new MRAM technology based on Spin-Orbit Torque (SOT) was recently discovered and offers better performance in terms of speed and endurance, at the expense of a slightly degraded density. In this paper, we also propose a comparative study of several architectures of SOT-MRAM memories for evaluating the possible advantages of this NV technology for high-speed applications.
Supplementary Table S5 from Safety Run-in of Intramuscular pNGVL4a-Sig/E7(detox)/HSP70 DNA and TA-CIN Protein Vaccination as Treatment for HPV16+ ASC-US, ASC-H, or LSIL/CIN1 (2023)

&lt;p&gt;Supplementary Table S5 shows the baseline blood counts and chemistry of study participants&lt;/p&gt;
Synthesis and Phase Stability of Metastable Bixbyite V2O3 Colloidal Nanocrystals (2013)

We have recently developed a colloidal route to vanadium sesquioxide (V2O3) nanocrystals with a metastable bixbyite crystal structure. In addition to being one of the first reported observations of the bixbyite phase in V2O3, it is also one of the first successful colloidal syntheses of any of the vanadium oxides. The nanocrystals, measuring 5 to 30 nm in diameter, possess a flower-like morphology which densify into a more spherical shape as the reaction temperature is increased. The bixbyite structure was examined by X-ray diffraction and an aminolysis reaction pathway was determined by Fourier transform infrared spectroscopy. A direct band gap of 1.29 eV was calculated from optical data. Under ambient conditions, the structure was found to expand and become less distorted, as evidenced by XRD. This is thought to be due to the filling of structural oxygen vacancies in the bixbyite lattice. The onset of the irreversible transformation to the thermodynamically stable rhombohedral phase of V2O3 occurred just under 500 °C in an inert atmosphere, accompanied by slight particle coarsening. A critical size of transformation between 27 and 42 nm was estimated by applying the Scherrer formula to analyze XRD peak widths during the course of the transformation. The slow kinetics of transformation and large critical size reveal the remarkable stability of the bixbyite phase over the rhombohedral phase in our nanocrystal system.