gebhart/patrepeval huggingface dataset:
Molecular classification of green tea catechin-sensitive and green tea catechin-resistant prostate cancer in the TRAMP mice model by quantitative real-time PCR gene profiling (2005)

We previously found that human prostate cancer (CaP) progression is accompanied by differential expression of a panel of 8 informative genes, some of which are metabolically related. Gene profiling focused on this 8-gene pack by northern blot analysis in combination with standard clinical information provided reliable prognostic prediction of human CaP. For a better insight into the potential of this 8-gene signature in tumor detection/classification and therapeutic response, we determined, by qPCR, the expression of these informative genes in the TRAMP mice model of CaP progression. The 8-genes signature resulted effective in discriminating, by linear discriminant analysis (LDA), the prostate of wild type mice from transgenic TRAMP mice developing CaP (P < 0.0002). Since it is known that Green Tea Catechin (GTC) administration to TRAMP mice results in a substantial delay of CaP progression in 80% of the animals, while 20% remain unresponsive, we determined the 8-gene signature in the prostates of GTC-sensitive and GTC-resistant mice. LDA discriminated benign tissue from CaP (i.e. wild-type + chemoprevented, GTC-sensitive TRAMP mice, in which CaP progression was delayed, was discriminated from TRAMP mice + GTC-resistant TRAMP mice, in which CaP developed irrespective of GTC administration; P < 0.01). Moreover, GTC-sensitive TRAMP mice bearing CaP were discriminated from GTCs-resistant ones, (P = 0.0001). These results show that qPCR gene profiling, based on the signature of the 8-genes selected by us, could represent an appropriate means for studying the biological behavior of CaP, which may lead to identifying new tools of potential prognostic value, in that a molecular classification for the presence/absence of cancer and for discriminating GTCs-responsive from GTC-resistant CaP is provided.
ChemInform Abstract: Synthesis of Novel 3‐ and 5‐Substituted Indole‐2‐carboxamides. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effect of added metal chelating organosilane on mesoporous titanosilicate formation properties (2003)

We describe the effects of adding the organosilane n-(trimethoxysilylpropyl)ethylenediaminetriacetic acid (EDATAS) during hydrothermal synthesis on the formation properties of titanium containing SBA-15 mesoporous silica. X-ray photoelectron spectroscopy revealed that the Si/Ti atomic ratio decreased significantly with the addition of the organosilane compared to the non-funtionalized silicates, showing that the EDATAS silicates contained more surface titanium. X-ray powder diffraction and nitrogen gas adsorption analysis revealed that the functionalized titanosilicates were ordered mesoporous materials with narrow pore size distributions with a BJH pore size of 92–96 Å. Solid state CP/MAS NMR experiments demonstrated that addition of EDATAS during hydrothermal synthesis produced a mesoporous silica with 6-coordinated Ti(IV) coordination. Using the same synthesis without the EDATAS, mesoporous silicas with 4-coordinated Ti(IV) were produced.
Evaluation of Dual-Frequency GBAS Performance using Data from Public Receiver Networks (2010)

This paper examines the effectiveness of two proposed methods for dual-frequency smoothing in Ground Based Augmentation Systems (GBAS) based on data collected in 2010 by clusters of nearby receivers whose measurements are publically available. After an extensive search turned up no ionospheric anomalies, data from several clusters of CORS and IGS stations under nominal conditions was examined, and results from three of these clusters are presented. Across these clusters, the variation with regard to receiver noise and multipath errors is very large. However, in all cases, dual-frequency smoothing performed well and generally agreed with theoretical predictions. These results confirm that future multiplefrequency GBAS systems using these methods are practical as long as receiver multipath is controlled to the level of the best CORS and IGS receivers.
MTHFD1 is a genetic interactor of BRD4 and links folate metabolism to transcriptional regulation (2018)

The histone acetyl-reader BRD4 is an important regulator of chromatin structure and transcription, yet factors modulating its activity have remained elusive. Here we describe two complementary screens for genetic and physical interactors of BRD4, which converge on the folate pathway enzyme MTHFD1. We show that a fraction of MTHFD1 resides in the nucleus, where it is recruited to distinct genomic loci by direct interaction with BRD4. Inhibition of either BRD4 or MTHFD1 results in similar changes in nuclear metabolite composition and gene expression, and pharmacologic inhibitors of the two pathways synergize to impair cancer cell viability in vitro and in vivo . Our finding that MTHFD1 and other metabolic enzymes are chromatin-associated suggests a direct role for nuclear metabolism in the control of gene expression.
Microbial Morphology and Motility as Biosignatures for Outer Planet Missions (2016)

Meaningful motion is an unambiguous biosignature, but because life in the Solar System is most likely to be microbial, the question is whether such motion may be detected effectively on the micrometer scale. Recent results on microbial motility in various Earth environments have provided insight into the physics and biology that determine whether and how microorganisms as small as bacteria and archaea swim, under which conditions, and at which speeds. These discoveries have not yet been reviewed in an astrobiological context. This paper discusses these findings in the context of Earth analog environments and environments expected to be encountered in the outer Solar System, particularly the jovian and saturnian moons. We also review the imaging technologies capable of recording motility of submicrometer-sized organisms and discuss how an instrument would interface with several types of sample-collection strategies. Key Words: In situ measurement-Biosignatures-Microbiology-Europa-Ice. Astrobiology 16, 755-774.
PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma (2020)

New strategies are needed to enhance the efficacy of anti-programmed cell death protein antibody (anti-PD-1 Ab) in cancer. Here, we report that inhibiting palmitoyl-protein thioesterase 1 (PPT1), a target of chloroquine derivatives like hydroxychloroquine (HCQ), enhances the antitumor efficacy of anti-PD-1 Ab in melanoma. The combination resulted in tumor growth impairment and improved survival in mouse models. Genetic suppression of core autophagy genes, but not Ppt1, in cancer cells reduced priming and cytotoxic capacity of primed T cells. Exposure of antigen-primed T cells to macrophage-conditioned medium derived from macrophages treated with PPT1 inhibitors enhanced melanoma-specific killing. Genetic or chemical Ppt1 inhibition resulted in M2 to M1 phenotype switching in macrophages. The combination was associated with a reduction in myeloid-derived suppressor cells in the tumor. Ppt1 inhibition by HCQ, or DC661, induced cyclic GMP-AMP synthase/stimulator of interferon genes/TANK binding kinase 1 pathway activation and the secretion of interferon-β in macrophages, the latter being a key component for augmented T cell-mediated cytotoxicity. Genetic Ppt1 inhibition produced similar findings. These data provide the rationale for this combination in melanoma clinical trials and further investigation in other cancers.
System Identification for Operational Controller Development of Hydraulic Excavator (2017)

Response to a regulation of exhaust gas, saving energy and automation are the most important assignment in the construction machinery industry. In late years, automated construction systems including ICT machinery are researched and partially in practical use. The systems require simulation techniques in early stage of the design. A highly reliable model enables large cost reduction if nonlinearity and uncertainty of the machinery is reproduced with more precision. This paper refers to high-accuracy parameter identification for a hydraulic servo model used in controller developments. The parameters are identified from a measurement data recorded with a commercial machine. In the model, input is rate of lever operation and output is operational velocity of hydraulic cylinder. A plant model consists of a dead band, dead time and quadric transfer function, and parameters of the plant model is identified by using differential evolution (DE). The parameter identification by DE shows superior accuracy and convergence than one by genetic algorithm. The result shows that a useful plant model for development is identified by DE.
Constructing Better Partial Sums Based on Energy-Maximum Criterion for Fast Encoding of VQ (2006)

In a vector quantization (VQ) framework, one of the key problems in its practical applications is the encoding speed. In order to speed up VQ encoding process, it is most important to avoid computing unnecessary k-dimensional (k-D) real Euclidean distances for the obviously unlikely candidate codewords. The mean, the variance and the two partial sums of a k-D vector have already been proposed as the effective features in the previous works in order to realize a rejection to the unlikely codeword by using just a little computational cost. It is clear that the mean and the variance of a k-D vector are constant but the two partial sums of a k-D vector are not constant depending on how they have been constructed. Therefore, how to construct two better partial sums for fast VQ encoding becomes important. Instead of using fixed the first half vector and the second half vector criterion that has been introduced in the previous works, this paper proposes a new energy-maximum criterion to construct two better partial sums for a k-D vector. Mathematical analysis and experimental results confirmed that the proposed criterion is much more effective for fast VQ encoding compared to the fixed criterion used in the previous works. In addition, it is very easy to use the energy-maximum criterion in practice
An energy-aware data cleaning workflow for real-time stream processing in the internet of things (2020)

The Internet of things (IoT) has recently transformed the internet, enabling the communication between every kind of objects (things). The growing number of sensors and smart devices enhanced data creation and collection capabilities and led to an explosion of generated data in the form of Data Streams. Processing these data streams is complex and presents challenges and opportunities in the stream processing field. Due to the inherent lacking of accuracy and completeness of sensor generated data, the quality of raw data is often poor. Data cleaning tasks are required to help increasing the quality of the data being processed in an IoT application. This work proposes a data stream processing workflow for IoT to be deployed at the edge of the network. It performs a fast data cleaning with low power consumption from edge and sensor nodes. The edge computing paradigm is used to bring the data cleaning task closer to the data sources and allow actions to be triggered immediately. In addition, an energy-aware data collection component is designed to reduce the network traffic and, as a consequence, decrease the power consumption of the network devices. The proposed workflow enables the deployment of long running real-time processing systems on remote outdoor environments.
Unlocking the observation of different proton populations in fluorinated polymers by solid-state 1H and 19F double resonance NMR spectroscopy (2016)

Nafion proton exchange membranes (PEMs) for fuel cell applications are extensively studied and commercially applied, but their unique proton conduction capabilities are still somewhat unexplained. For studying proton dynamics in situ, molecular level spectroscopic techniques have been of limited utility so far. By solid-state <sup>1</sup>H and <sup>19</sup>F double resonance nuclear magnetic resonance (NMR) spectroscopy using the recently revived multiple contact cross-polarization (MC-CP) pulse sequence along with double-quantum <sup>1</sup>H-<sup>1</sup>H filtering, high resolution proton populations distinct from the dominant water resonance were observed in Nafion for the first time. This methodology quenches signal decay due to spin-lattice relaxation in the rotating frame and enables magnetization transfer between the relatively mobile <sup>1</sup>H and <sup>19</sup>F spin baths in Nafion. Further studies of these previously unrevealed proton populations will lead to a better understanding of the Nafion proton conduction mechanism and proton exchange processes in general.
Session 26 overview: Wireless for IoE (2016)

This session features numerous low-power wireless techniques and systems to address the challenges of IoE. Presented are an ADPLL-based hybrid-loop BLE receiver, an ultra-low-power receiver using transmitted reference modulation, a fully digital IEEE 802.11ah-compliant polar transmitter, an ETSI Class-1-compliant IoE transceiver, a GNSS receiver aimed at IoE applications, a Filtering-by-Aliasing receiver, a syringe-implantable radio system on glass substrate including antenna, a BLE-compliant wake-up radio and an N-path switched-capacitor-based transceiver.
Micromagnetism and high temperature coercivity of MnBi/Al multilayers (2000)

The micromagnetic properties of multilayered MnBi/Al films have been investigated and compared to pure MnBi thin films. Pure MnBi films reveal an anomalous increase of the high temperature coercivity, which has been explained on the basis of a hybrid domain wall pinning model. The multilayer-type preparation of MnBi/Al thin films results in significantly reduced MnBi particle size of approximately 40 nm. The smaller particle size leads to a change of the dominant magnetization reversal process from one driven by domain wall movement toward coherent rotation. This was investigated via magnetic force microscopy imaging and micromagnetic calculations. The absence of domain walls during magnetization reversal results in a clear suppression of the increase of the high temperature coercivity observed in pure MnBi films.
Supplementary Figure 1 from Mechanistic Contribution of Ubiquitous 15-Lipoxygenase-1 Expression Loss in Cancer Cells to Terminal Cell Differentiation Evasion (2023)

&lt;p&gt;PDF file - 427KB&lt;/p&gt;
Theoretical analysis of magnetic wall decoupling method for radiative antenna arrays in ultrahigh magnetic field MRI (2015)

ABSTRACT Radiative antenna techniques, e.g., dipole and monopole, have been proposed for radiofrequency (RF) coil array designs in ultrahigh field MRI to obtain stronger B 1 field and higher signal‐to‐noise ratio (SNR) gain in the areas deep inside human head or body. It is known that element decoupling performance is crucial to SNR and parallel imaging ability of array coil and has been a challenging issue in radiative antenna array designs for MR imaging. Magnetic wall or induced current elimination (ICE) technique has proven to be a simple and effective way of achieving sufficient decoupling for radiative array coils experimentally. In this study, this decoupling technique for radiative coil array was analyzed theoretically and verified by a simulation study. The decoupling conditions were derived and obtained from the theory. By applying the predicated decoupling conditions, the isolation of two radiative elements could be improved from about − 8 dB to better than − 35 dB. The decoupling performance has also been validated by current distribution along the radiative elements and magnetic field profiles in a water phantom. © 2015 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 45B: 183–190, 2015
Conduction band states in AlP/GaP quantum wells (2008)

International audience
Abstract 1279: Investigating the impact of PGC-1α-coupled metabolic reprogramming on breast cancer metastasis (2023)

Abstract Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) is a transcriptional coactivator known to play a role in regulating cellular metabolism, contributing to pathways such as mitochondrial respiration, glutaminolysis, and lipogenesis. PGC-1α has been shown to promote cancer metastasis in mouse models of breast cancer while increasing both the global bioenergetic capacity and metabolic flexibility of breast cancer cells. However, the molecular mechanisms through which PGC-1α contributes to metabolic reprogramming to support breast cancer metastasis remain unknown. To address this, we have generated the first transgenic mouse model of breast cancer lacking PGC-1α expression specifically in the mammary epithelium (PGC-1α null), allowing us to examine how PGC-1α loss impacts breast cancer initiation, progression, and metastasis. While no significant differences were observed in tumour onset or growth between wild-type and PGC-1α null mice, lung metastatic burden was decreased in PGC-1α null mice. Ion pairing liquid chromatography-mass spectrometry was employed to measure steady state metabolite levels in mammary tumours collected from wild-type and PGC-1α null mice. By integrating our metabolomics data with RNA sequencing data from wild-type and PGC-1α null tumours, we identified potential deficits in glycolysis and aspartate metabolism in the context of mammary epithelial PGC-1α loss. Interestingly, RNA sequencing further revealed the downregulation of several genes involved in extracellular matrix remodelling in PGC-1α null tumours. Through immunohistochemistry, we further observed lower levels of α smooth muscle actin, a marker of cancer-associated fibroblasts, in PGC-1α null tumours compared with wild-type tumours. Overall, PGC-1α knockout impedes metastasis to the lung in mouse models of breast cancer. Moreover, our transgenic mouse model suggests possible cell intrinsic and extrinsic roles for PGC-1α expression, influencing breast cancer cell metabolism as well as fibroblast activation and extracellular matrix remodelling in the tumour microenvironment. By developing cell lines modeling PGC-1α overexpression or knockdown in luminal B, HER2+, and triple negative breast cancer, we will validate the findings from our transgenic mouse model and further elucidate how PGC-1α reprograms metabolism in breast cancer, how PGC-1α expression influences the tumour microenvironment, and how these mechanisms contribute to cancer cell invasion, anoikis-resistance, and metastasis. Citation Format: Emma Ciccolini, Valérie Sabourin, David Patten, Young K. Im, Steven Hébert, William J. Muller, Claudia Kleinman, Julie St-Pierre, Josie Ursini-Siegel. Investigating the impact of PGC-1α-coupled metabolic reprogramming on breast cancer metastasis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1279.
Contamination mitigation of hydrogen silsesquioxane resist processed with Na+-containing developer for nanoscale CMOS device patterning (2014)

Research on continued complementary metal–oxide–semiconductor (CMOS) scaling has sparked an interest in fabricating silicon-based devices with features in the sub-30 nm pitch regime. Electron beam lithography using hydrogen silsesquioxane (HSQ) resist processed with developers that contain ionic salts, e.g., Na+, has demonstrated a way to cleanly pattern features in the 20–30 nm pitch regime. Contamination concerns, however, have prevented the application of salty developed HSQ to silicon CMOS device integration in laboratories with stringent contamination controls. This paper details the results of a study aimed at understanding and reducing the residual contamination of salty developer to a level suitable for continued processing in a CMOS device research line. Data from total reflection x-ray fluorescence measurements shows that significant levels of Na+ as well as other unexpected metal contaminants remain on substrates after the develop process. Capacitance versus voltage measurements of capacitor structures were used to demonstrate that the Na+ contamination can be removed through a rigorous rinsing protocol. However, the metal contaminants proved harder to eliminate and required formulation of the developer solution using high purity constituent components. Using these protocols, integrated FinFET capacitors with a minimum Silicon fin pitch of 30 nm were successfully fabricated. The data from these devices show nominal device characteristics with no indication of ionic or metal contamination.
Supplementary Materials and Methods, Supplementary Table 2, and Supplementary Figures 1 and 2 from Neutralization of KIT Oncogenic Signaling in Leukemia with Antibodies Targeting KIT Membrane Proximal Domain 5 (2023)

&lt;p&gt;Materials and methods describing the production of scFv-Fc in HEK-T cells and KIT domains and scFv display on yeast. Table S2: Primers for PCR amplification of KIT and cloning into pYD vector by Gap repair. Figure S1: Selection and initial characterization of a panel of anti-KIT scFv. Figure S2: Anti-KIT D5 epitope characterization using yeast display.&lt;/p&gt;
Density control of carbon nanotubes for field emission display by control of catalytic layer diffusion (2006)

In this report, we have controlled the growth of multiwalled carbon nanotubes (MWNT) in terms of the populations and diameters by introducing a buffer layer between catalytic layer and amorphous silicon coated substrates. The carbon nanotubes growth with the chemical vapor deposition technique might produce interaction of the metallic catalyst with silicon layer, which could interrupt the catalytic effect. We will show how control of diffusion layer between the amorphous silicon and metal catalyst effectively control the formation of the silicide phase and consequently optimize the carbon nanotubes growth. It is performed on amorphous silicon coated glass by infrared radiation heated thermal chemical vapor deposition(CVD), using a gas mixture of carbon mono-oxide and hydrogen and Fe-Ni-Co alloy catalyst at temperatures as low as 480/spl sim/580/spl deg/C.
Advances on drug-coated balloons. (2010)

During the last decades considerable advances have been made in intravascular interventions for the treatment of coronary and peripheral arterial disease. However, long-term outcome remains an area of concern in many applications. Restenosis is still a challenge in endovascular medicine and has thus been referred to as the Achilles' heel of percutaneous intervention. Therefore, novel strategies have been developed to overcome this problem. These include drug-eluting stents, though still associated with stent thrombosis and in-stent restenosis, and the more recently introduced non-stent based local drug delivery systems, especially the paclitaxel-eluting balloon. Results of several preclinical and clinical studies indicate that short-term exposure of injured arteries to paclitaxel eluted from regular PTA and PTCA balloons may be sufficient to reduce late lumen loss and restenosis rates during a critical period of time after angioplasty of diseased coronary and peripheral arteries. Although the number of published trials and patients treated is still limited, available data seem to prove that restenosis inhibition by immediate drug release is feasible. This article reviews the rationale for the use of paclitaxel-coated balloons, data from preclinical and clinical studies, and the perspective of drug-coated balloons in peripheral arterial disease.
L-band 64×10 Gb/s DWDM transmission over 500 km DSF with 50 GHz channel spacing (2002)

We demonstrate error-free transmission of 64 DWDM 10 Gb/s channels in the L-band with 50 GHz channel spacing over 5/spl times/100 km spans of dispersion-shifted fiber.