gebhart/patrepeval huggingface dataset:
Robust BSBL recovery method of physiological signals with application to fetal ECG (2016)

Compressive Sensing (CS) techniques have emerged with the increasing demand of high data rate transmissions. Recently, block sparse Bayesian learning (BSBL) framework was introduced which has a superior performance over conventional CS methods. In this paper, the BSBL-Expectation Maximization (BSBL-EM) and BSBL-Bound Optimization (BSBL-BO) methods were deployed. The performance, mainly quality and speed, of recovering a block sparse signal was analyzed. Results showed that the two algorithms performance is almost the same in terms of NMSE. However, BSBL-BO achieved better efficiency since the required recovery time was less than BSBL-EM. To further investigate the algorithms performance, they were deployed to recover a real world FECG segment. They achieved a satisfactory quality where the distortion is negligible and does not affect the clinical diagnosis. Nevertheless, using BSBL-BO is more suitable for wireless tele-monitoring based systems since it is more efficient.
P-152 YI Detection and Measurement of Changes in mRNA Colonic Expression of Inflammatory Genes in Biopsies from Patients with Ulcerative Colitis (2013)

The ability to measure mRNA expression of pro-inflammatory cytokines in colonic biopsies from patients with ulcerative colitis is critical for proof of concept and mechanism of action studies. Little published data exist on how many biopsies per patient and how many patients need to be studied to provide accurate, precise, and reproducible results. We performed a cross sectional study in patients with ulcerative colitis with both inactive and active disease to systematically validate methods for detecting and measuring transcriptional changes in inflammatory genes in colonic biopsies from regions where inflammation is continuous and homogenous. A total of 12 colonic biopsies were obtained from patients with ulcerative colitis during colonoscopy. Three biopsies were obtained from each of the: 1) ascending; 2) transverse; 3) descending and 4) recto-sigmoid colon. Using quantitative PCR, mRNA expression was assessed for inflammatory genes that have been associated with ulcerative colitis: Interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α (TNF), IP-10 (interferon gamma-induced protein), C-X-C motif chemokine 13(CXCL13), matrix metalloproteinase-3 (MMP-3), and S100-A8 (calcium binding protein). The Mayo Score and endoscopic subscore of the Mayo score for each colonic segment were recorded for each participant. A linear mixed model utilizing repeat measures was used to calculate the power to detect a reduction in gene expression corresponding to concentrations in active as compared to inactive ulcerative colitis. Colonic biopsies were obtained from 13 patients with ulcerative colitis: 6 patients with inactive disease and 7 patients with active disease. Biopsies yielded sufficient RNA sufficient to measure approximately 260 inflammatory markers. Mayo Endoscopic subscores for each colonic segment correlated with inflammatory gene expression. The mean coefficient of variation for 3 colonic biopsies in a colonic segment ranged from 26% to 83% depending on which inflammatory gene was measured. Obtaining 2 rectal biopsies for TNF-α reduced sampling error to acceptable levels with a standard error of less than 25%. Overall variability was assessed to calculate the power of sampling in similar cohorts to detect changes in inflammatory gene expression corresponding to active versus inactive ulcerative colitis. Depending on the specific inflammatory marker, 3 to 6 biopsies from 6 patients would obtain a power of 80% with alpha of 0.05. Early phase proof of concept and mechanism of action studies that measure mRNA expression of pro-inflammatory cytokines in colonic biopsies from patients with ulcerative colitis are feasible. Three to 6 biopsies obtained from 6 patients provide sufficient power for such studies.
ChemInform Abstract: SUPPORTED ORGANOACTINIDES. SURFACE CHEMISTRY AND CATALYTIC PROPERTIES OF ALUMINA‐BOUND CYCLOPENTADIENYL AND PENTAMETHYLCYCLOPENTADIENYL THORIUM AND URANIUM HYDROCARBYLS AND HYDRIDES (1985)

Abstract Eine genaue quantitative Untersuchung der Oberflächenchemie und Katalyse ausgewählter Verbindungen wie (I)‐(IV) an teilweise oder ganz dehydroxylienem Al 2 O 3 als Träger gebunden wird angestellt.
Cu/SiO2Hybrid Bonding (2012)

This chapter contains sections titled: Introduction Blanket Cu/SiO2 Direct Bonding Principle Blanket Copper Direct Bonding Principle Electrical Characterization Die-to-Wafer Bonding Conclusion Acknowledgment References
Effects of a High-k Dielectric on the Performance of III–V Ballistic Deflection Transistors (2012)

This letter presents a first successful integration of a high-k dielectric, i.e., Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> , with III-V semiconductors in ballistic deflection transistors (BDTs). The Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> is deposited using atomic layer deposition, which allows the formation of uniform layers along the walls of etched trenches. The BDT transfer characteristic shows strong dependence on the dielectric permittivity of the material filling the etched trenches. When Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> is deposited in the trenches, the transconductance of the BDT is enhanced and shifted to lower gate bias. Moreover, the ratio between output and leakage currents was also enhanced.
Excellent oxidation endurance of boron nitride nanotube field electron emitters (2014)

Boron nitride nanotubes (BNNTs) are considered as a promising cold electron emission material owing to their negative electron affinity. BNNT field emitters show excellent oxidation endurance after high temperature thermal annealing of 600 °C in air ambient. There is no damage to the BNNTs after thermal annealing at a temperature of 600 °C and also no degradation of field emission properties. The thermally annealed BNNTs exhibit a high maximum emission current density of 8.39 mA/cm2 and show very robust emission stability. The BNNTs can be a promising emitter material for field emission devices under harsh oxygen environments.
Développement de cœurs de piles à combustible par procédés plasma (2008)

National audience
User participation and compliance in speech automated telecommunications applications (1996)

This paper reviews results from a number of field trials assessing speech recognition feasibility for telecommunications services.Several applications incorporating speech automation are explored: Directory Assistance Call Completion (DACC), partial speech automation of Directory Assistance (OSF -Operator Store and Forward), banking over the telephone (Money Talks) and partial speech automation of a customer calling center (PREVIU).The experimental results presented here were collected through Wizard-of-Oz experiments as feasibility precursors to speech recognition automation.Speech interfaces were clearly superior to Touch-Tone in one experiment (PREVIU), with caller participation increasing by 30%.In another experiment (Money Talks), speech recognition interfaces did not improve caller participation and, in fact, provided no advantages over Touch-Tone automation.A number of prompting strategies have been identified as advantageous in increasing caller participation and compliance in automated services.Ultimately, success with speech automated services will rely on identifying the services most suitable for speech automation and then carefully crafting the user interface.
Application of serum natalizumab levels during plasma exchange in MS patients with progressive multifocal leukoencephalopathy (2014)

Progressive multifocal leukoencephalopathy (PML) is a severe complication of natalizumab treatment. Restoring immune function by plasmapheresis/immunoadsorption (PLEX/IA) is important for the outcome of PML. We report on four multiple sclerosis (MS) patients whom developed PML during natalizumab treatment, in whom we measured serum natalizumab concentrations before and during PLEX. Depending on the serum natalizumab concentration at the time of PML diagnosis, the number of PLEX treatments necessary to reach subtherapeutic serum natalizumab concentrations is variable. Measuring serum natalizumab concentrations before and during PLEX is helpful to determine the optimum number of PLEX treatments in individual MS patients with PML.
Molecular definition of a region of chromosome 21 that causes features of the Down syndrome phenotype. (1990)

Down syndrome (DS) is a major cause of mental retardation and heart disease. Although it is usually caused by the presence of an extra chromosome 21, a subset of the diagnostic features may be caused by the presence of only band 21q22. We now present evidence that significantly narrows the chromosomal region responsible for several of the phenotypic features of DS. We report a molecular and cytogenetic analysis of a three-generation family containing four individuals with clinical DS as manifested by the characteristic facial appearance, endocardial cushion defect, mental retardation, and probably dermatoglyphic changes. Autoradiograms of quantitative Southern blots of DNAs from two affected sisters, their carrier father, and a normal control were analyzed after hybridization with two to six unique DNA sequences regionally mapped on chromosome 21. These include cDNA probes for the genes for CuZn-superoxide dismutase (SOD1) mapping in 21q22.1 and for the amyloid precursor protein (APP) mapping in 21q11.2-21.05, in addition to six probes for single-copy sequences: D21S46 in 21q11.2-21.05, D21S47 and SF57 in 21q22.1-22.3, and D21S39, D21S42, and D21S43 in 21q22.3. All sequences located in 21q22.3 were present in three copies in the affected individuals, whereas those located proximal to this region were present in only two copies. In the carrier father, all DNA sequences were present in only two copies. Cytogenetic analysis of affected individuals employing R and G banding of prometaphase preparations combined with in situ hybridization revealed a translocation of the region from very distal 21q22.1 to 21qter to chromosome 4q. Except for a possible phenotypic contribution from the deletion of chromosome band 4q35, these data provide a molecular definition of the minimal region of chromosome 21 which, when duplicated, generates the facial features, heart defect, a component of the mental retardation, and probably several of the dermatoglyphic changes of DS. This region may include parts of bands 21q22.2 and 21q22.3, but it must exclude the genes S0D1 and APP and most of band 21q22.1, specifically the region defined by S0D1, SF57 and D21S47.
ChemInform Abstract: Improved Synthesis of Cubane‐1,2,4,7‐tetracarboxylic Acid. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Compact Modeling of Long-Term MOSFET Degradation for Predicting Circuits Degradation (2016)

We propose a prediction method of long-term metal oxide semiconductor field effect transistors (MOSFETs) degradation to realize CMOS circuit design for reliability. Negative bias temperature instability (NBTI) and hot carrier effect are considered as physical origins of the degradation. During long-term use, CMOS circuit degradation affects the circuit operation. Moreover the circuit operation also affects the CMOS circuit degradation. The develeped method can be utilized for this purpose even after long-term use, and has been verified at different long-term stress conditions by comparison with the actual transient simulation using physical models.
Abstract P4-04-07: Progesterone promotes immunomodulation and tumor development in the murine mammary gland (2022)

Abstract Clinical studies have linked usage of progestins (synthetic progesterone) to breast cancer risk. However, little is understood regarding the role of native progesterone (P4), signaling through the progesterone receptor (PR), in breast tumor formation. Recently, we reported a link between PR and immune signaling pathways, showing that P4/PR can repress type I interferon signaling pathways. Given these findings, we sought to investigate whether P4/PR drive immunomodulation in the mammary gland and promote tumor formation. To determine the effect of P4 on immune cell populations in the murine mammary gland, mice were treated with P4 or placebo pellets for 21 days. We found that mice treated with P4 exhibited changes in the mammary gland indicative of an inhibited immune response compared to placebo-treated mice. To assess the effect of PR overexpression on mammary gland tumor development as well as immune cell populations in the mammary gland, a transgenic mouse model was used in which PR is overexpressed throughout the entire mouse. Immune cell populations were assessed in the mammary glands by flow cytometry, which revealed decreased numbers of various immune cell populations. Transgenic mice were also monitored for mammary gland tumor development over a 2-year timespan. Following development of mammary gland tumors, immune cell populations in the tumors and spleens of transgenic and control mice were analyzed by flow cytometry. Upon long-term monitoring, we determined that multi-parous PR overexpressing mice developed significantly more mammary gland tumors than control mice. Additionally, tumors from PR overexpressing mice contained fewer infiltrating immune cells, and RNA sequencing analysis of tumor samples revealed that immune-related gene signatures were lower in tumors from PR overexpressing mice as compared to control mice. Finally, we utilized syngeneic mammary gland tumor models to evaluate the effect of P4 on the growth of PR+ mammary gland tumors in vivo, which revealed that P4 promoted tumor growth and decreased immune cell infiltration of PR+ mammary gland tumors. Together, these findings offer a novel mechanism of P4-driven mammary gland tumor development and provide rationale in investigating the usage of anti-progestin therapies to promote immune-mediated elimination of mammary gland tumors. Citation Format: Lauryn R Werner, Katelin A Gibson, Merit L Goodman, Dominika E Helm, Katherine R Walter, Sean M Holloran, Gloria M Trinca, Richard C Hastings, Howard H Yang, Ying Hu, Junping Wei, Gangjun Lei, Xiao-Yi Yang, Rashna Madan, Alfred A Molinolo, Mary A Markiewicz, Prabhakar Chalise, Margaret L Axelrod, Justin M Balko, Kent W Hunter, Zachary C Hartman, Carol A Lange, Christy R Hagan. Progesterone promotes immunomodulation and tumor development in the murine mammary gland [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P4-04-07.
Influence of corrosion of self-piercing riveted high strengthaluminium alloy joints with button cracks on the mechanical strength (2018)

For high strength aluminium alloys, such as AA6008T61 and AA6111 PFHT, when they are joined as the bottom material by self-piercing riveting (SPR), they tend to crack at the joint buttons. These cracks, especially those penetrated to the rivets, may cause galvanic corrosion problem with the steel rivet. In this paper, the mechanical strength of four stack/die combinations with different joint button cracking severity was studied before and after salt-spray corrosion test. The results showed that corrosion on the severely cracked joints was worse than that on the joints with small cracks and the corrosion on the stack with the same top and bottom material was less than that on the stack with different top and bottom materials. For all joints the static lap shear strength after corrosion was improved, but the static T peel strength after corrosion was slightly reduced or did not have obvious change. The results also showed that after corrosion the lap shear fatigue strength of the specimens with severe cracks did not have obvious change, but the lap shear fatigue strength of the specimens with small cracks slightly reduced.&#13;\n&#13;\n
Modeling Facial Geometry Using Compositional VAEs (2018)

We propose a method for learning non-linear face geometry representations using deep generative models. Our model is a variational autoencoder with multiple levels of hidden variables where lower layers capture global geometry and higher ones encode more local deformations. Based on that, we propose a new parameterization of facial geometry that naturally decomposes the structure of the human face into a set of semantically meaningful levels of detail. This parameterization enables us to do model fitting while capturing varying level of detail under different types of geometrical constraints.
Application of Decoy Oligodeoxynucleotides for Arthritis (2006)

Recent progress in DNA technologies has provided the strategies to regulate the transcription of disease-related genes in vivo using antisense oligodeoxynucleotide (ODN). Transfection of cis-element double-stranded oligodeoxynucleotides (decoy ODNs) has been reported as a new therapeutic tool of anti-gene strategies for gene therapy. In the field of arthritis, decoy ODNs strategies have been significant therapeutic potential. The concept of regulation the disease related gene expression at the level of transcriptional factor may be more therapeutic effects compared with monotherapy in arthritis.
Living Santería: Rituals and Experiences in an Afro-Cuban Religion (2004)

Review Article| July 01 2004 Living Santeríía: Rituals and Experiences in an Afro-Cuban Religion Michael Atwood Mason Michael Atwood Mason Search for other works by this author on: This Site PubMed Google Scholar Nova Religio (2004) 8 (1): 120–121. https://doi.org/10.1525/nr.2004.8.1.120 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Michael Atwood Mason; Living Santeríía: Rituals and Experiences in an Afro-Cuban Religion. Nova Religio 1 July 2004; 8 (1): 120–121. doi: https://doi.org/10.1525/nr.2004.8.1.120 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentNova Religio Search This content is only available via PDF. ©© 2004 by The Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.
Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate (1998)

Signal transduction across cell membranes often involves the activation of both phosphatidylinositol (PI)-specific phospholipase C (PLC) and phosphoinositide 3-kinase (PI 3-kinase). Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a substrate for both enzymes, is converted to phosphatidylinositol 3,4, 5-trisphosphate (PI(3,4,5)P3) by the action of PI 3-kinase. Here, we show that PI(3,4,5)P3 activates purified PLC-gamma isozymes by interacting with their Src homology 2 domains. Furthermore, the expression of an activated catalytic subunit of PI 3-kinase in COS-7 cells resulted in an increase in inositol phosphate formation, whereas platelet-derived growth factor-induced PLC activation in NIH 3T3 cells was markedly inhibited by the specific PI 3-kinase inhibitor LY294002. These results suggest that receptors coupled to PI 3-kinase may activate PLC-gamma isozymes indirectly, in the absence of PLC-gamma tyrosine phosphorylation, through the generation of PI(3,4,5)P3.
Pathogenesis of the 1918 Pandemic Influenza Virus (2011)

At the height of World War I, the human population was assaulted by a powerful, but very small, foreign agent that rapidly appeared seemingly from nowhere. Ultimately identified as the “Spanish flu”, this agent wreaked havoc on anyone in its path. Prostrating vast numbers of victims worldwide with severe pneumonia, which often progressed to a fatal outcome, the “Spanish flu” caused an estimated 20–50 million deaths worldwide [1]. The resultant 1918 pandemic was one of the most formidable foes faced by humankind. In this brief review, we discuss some recent insights into the pathogenicity of its causative agent, the 1918 pandemic influenza virus.
Effect of Novel Chelating Agent Seawater Based System on the Integrity of Sandstone Rocks (2017)

Abstract The objective of sandstone acidizing the objective is to reduce the skin around the wellbore. This process may affect the stability of the formation and may decrease the efficiency of the stimulation job. One of the main problems related to rock integrity is sand production. Sand causes erosion of surface and down hole equipment. The objective of this work is to introduce DTPA (diethylene tri-amine pentaacetic acid) to sandstone acidizing. Moreover, use mechanical properties estimated based on acoustic measurements to address the impact of the new formulation on the integrity of Bandera and Berea sandstone cores after stimulation. In this study, DTPA and EDTA (ethylene di-amine tetra-acetic acid) chelating agents at high pH diluted with seawater combined with potassium carbonate were used to acidize Bandera and Berea sandstone cores. Core flooding system was used to acidize the sandstone samples. Non-destructive tests were conducted to evaluate the effect of injected solution volume on the rock integrity. The samples were scanned using Computed Tomography (CT) to detect any precipitations after using the seawater based chelating agents. The results showed that DTPA and EDTA chelating agents at pH of 11 diluted using sea water injected at rate of 5 cm3/min into 2-inch Bandera and Berea sandstone cores at temperature of 250°F enhanced the permeability ratio. Furthermore, increasing the fluid injected pore volumes raised the permeability improvement ratio of the sandstone cores. CT-number of the treated samples decreased which means no precipitations formed inside the cores. Elastic moduli of the cores after the acidizing showed that the integrity of the samples was not affected and no sand production is expected under the flooding conditions. The obtained results of this work will provide the engineers with sandstone acidizing seawater based fluids that will not affect the rock integrity after stimulation.
Supplemental Figure 1 from MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor (2023)

&lt;p&gt;Supplemental Figure 1: Validation of MCL-1 siRNA.&lt;/p&gt;