gebhart/patrepeval huggingface dataset:
Phase I/II study of 225Ac-J591 plus 177Lu-PSMA-I&T for progressive metastatic castration-resistant prostate cancer. (2022)

TPS5100 Background: PSMA is overexpressed by most prostate cancers and can be successfully targeted by both antibodies (mAb) and small molecule ligands (SML), each with overlapping and distinct binding sites, kinetics, and biodistributions [Kratochwil Sem Nuc Med 2019]. mAbs are larger, with longer circulating times resulting in greater exposure to bone marrow, but lesser access to PSMA expression on luminal tissue ( e.g. salivary glands, small bowel, and kidney). In contrast, SMLs are rapidly excreted via kidneys and readily diffuse to all PSMA-expressing sites. Toxicities of 177Lu vary with these differences in biodistribution ( e.g. more hematologic toxicity with mAb, more xerostomia and nausea with SML, p &lt; 0.001)[Niaz AUA 2020]. Alpha emitting isotopes have shorter ranges but high potency compared to beta emitters which have longer ranges, but lower linear energy transfer. In preclinical models, the combination of mAb plus SML has demonstrated additive binding in LNCaP, CWR22Rv1, and PC3/PSMA PC cell lines, and synergistic uptake of 177Lu-mAb plus 177Lu-SML in xenograft models. We developed a phase I/II study to test our hypothesis that concomitant mAb and SML targeting, plus the combination of alpha (225Ac) and beta emitters (177Lu), may offer complementary benefits in a safe and effective manner. Methods: Key eligibility criteria include progressive mCRPC (PCWG3), at least 1 prior AR pathway inhibitor and taxane chemotherapy (or ineligible/refused), and adequate organ function and performance status. PSMA PET/CT must have at least 1 lesion with SUVmax &gt; liver SUV. Prior PSMA-based therapy with radioisotopes is not allowed. 177Lu-PSMA-I&amp;T (PNT2002) will be administered as in the phase III SPLASH study (6.8 GBq q8w for up to 2 doses). The phase I includes up to two dose-escalation cohorts of concurrent 225Ac-J591 (30 &amp; 40 KBq/Kg q8w x2) in a modified 3+3 schema. All subjects undergo 177Lu SPECT on Day 8 after each dose. The primary objective of the Phase I study is to determine the dose-limiting toxicity and recommended phase II dose (RP2D) for this combination. Primary objective of the Phase II study is to assess the proportion of patients with &gt; 50% PSA decline after treatment. Secondary objectives include radiographic response rate (PCWG3-modified RECIST 1.1), biochemical and radiographic progression-free survival, overall survival, safety (CTCAE 5.0), CTC count changes and conversions, and patient-reported outcomes (FACT-P, BPI-SF, EQ-5D). Exploratory objectives include pre- and post-treatment PSMA-based imaging changes, effects of PSMA radionuclides on the microbiome, relationship between genomic alterations and response, and relationship between PSMA PET/CT results and outcome. The phase I was activated at Weill Cornell Medicine in May 2021. Following determination of the RP2D, a multicenter phase II is planned at Prostate Cancer Clinical Trials Consortium (PCCTC) in 2022. Clinical trial information: 04886986.
Room temperature fabrication of semiconductor interfaces (2017)

Summary form only given. A new technology was developed allowing for room temperature covalent bonding. The surface preparation method allows for in situ native oxides removal and fabrication of oxide-free bonded interfaces which could be directly used in fabrication of various devices (e.g. solar cells).
Optical fiber structures studied by a tapping-mode scanning near-field optical microscope (1997)

A tapping-mode scanning near-field optical microscope system with a bent optical fiber probe has been successfully developed to study the near-field optics at fiber end faces. Topographic and near-field intensity images of fiber end faces were obtained simultaneously. A brief and gentle etching process on fiber end faces in a saturated solution of ammonium bifluoride was able to reveal the structures of fibers. The topographic features generated by different local chemistry is closely related to the local doping concentration and the distribution of refractive index. The correlation between fiber structures and their near-field intensity profiles of propagating modes can be acquired directly by this novel method. Fibers of step-index, graded-index, single-mode, multimode, and circular, or noncircular geometry were imaged with a near-field resolution.
Examining the Impact of Prior Models in Transmural Electrophysiological Imaging: A Hierarchical Multiple-Model Bayesian Approach (2015)

Noninvasive cardiac electrophysiological (EP) imaging aims to mathematically reconstruct the spatiotemporal dynamics of cardiac sources from body-surface electrocardiographic (ECG) data. This ill-posed problem is often regularized by a fixed constraining model. However, a fixed-model approach enforces the source distribution to follow a pre-assumed structure that does not always match the varying spatiotemporal distribution of actual sources. To understand the model-data relation and examine the impact of prior models, we present a multiple-model approach for volumetric cardiac EP imaging where multiple prior models are included and automatically picked by the available ECG data. Multiple models are incorporated as an Lp-norm prior for sources, where p is an unknown hyperparameter with a prior uniform distribution. To examine how different combinations of models may be favored by different measurement data, the posterior distribution of cardiac sources and hyperparameter p is calculated using a Markov Chain Monte Carlo (MCMC) technique. The importance of multiple-model prior was assessed in two sets of synthetic and real-data experiments, compared to fixed-model priors (using Laplace and Gaussian priors). The results showed that the posterior combination of models (the posterior distribution of p) as determined by the ECG data differed substantially when reconstructing sources with different sizes and structures. While the use of fixed models is best suited in situations where the prior assumption fits the actual source structures, the use of an automatically adaptive set of models may have the ability to better address model-data mismatch and to provide consistent performance in reconstructing sources with different properties.
Stimulation of sugar uptake and glycolysis in chicken embryo fibroblasts by the major glycoprotein from avian myeloblastosis virus. (1979)

Addition of purified major glycoprotein from avian myeloblastosis virus to growing or quiescent chicken embryo fibroblasts rapidly stimulates the rate of hexose transport and increases the lactic acid production. These stimulatory effects are dependent on the time of exposure and the dose of viral glycoprotein. In contrast, the glycoprotein only marginally affects hexose transport in chicken cells transformed by Rous sarcoma virus. Some effects of the glycoprotein on serum-starved quiescent cells were similar to those observed upon re-addition of serum; however, the viral glycoprotein did not stimulate DNA synthesis. Quiescent cells stimulated by saturating levels of serum showed little further stimulation of hexose uptake upon exposure to viral glycoprotein for 3 hr. This behavior suggests that the glycoprotein may be acting on a system that is also a target for serum action.
Segmental Dynamics and Ionic Conduction in Poly(vinyl methyl ether)−Lithium Perchlorate Complexes (2004)

Broadband dielectric spectroscopy was used to investigate the segmental dynamics and ionic conduction in LiClO4/PVME complexes with Li/O from 0.1/100 to 10/100, at temperatures from Tg to approximately Tg + 80 degrees C. Although no microphase separation is observed via DSC, dielectric experiments reveal two segmental relaxations and one localized ion motion process. The fastest process is attributed to relaxations of segments in ion-depleted domains and it slows down with increasing salt content, as does the ion motion. The segmental relaxation of PVME chains in ion-rich domains is even slower than the ion motion process, and about 104 times slower than the fast segmental process in the 0.5/100 complex. This process becomes faster with increasing LiClO4 content, despite the concurrent increase in the bulk Tg. Maximum molar conductivity is obtained in the 2/100 complex and the ionic conduction is about 10-9 S/cm at 30 degrees C. By using the dynamic bond percolation model, it was found that the ions move about 0.8 nm for the 0.5/100 complex at 25 degrees C at the time scale of the slow segmental relaxation, assuming that structural renewal is realized by the latter. This size, together with the strong correlation between the ionic conduction and the slow segmental relaxation, supports the idea that hopping from one segment to another one is probably the effective fundamental step giving rise to macroscopic conduction.
Quantifying Collaboration on Computationally-Enhanced Tables (2004)

Figure-of-eight sutures provided efficient hemostasis following AF ablation, with significantly reduced postprocedure recovery time including time to hemostasis, extubation, and transport out of the lab.
THE EFFECT OF DIALYSATE CALCIUM CONCENTRATION AND l α‐HYDROXY VITAMIN D, ON SKELETAL CALCIUM LOSS AND HYPERPARATHYROIDISM IN H AEMO DIA L YSIS PATIENTS (1977)

The response of hyperparathyroidism and skeletal calcium loss in haemodialysis patients to treatment with 1alpha-hydroxyvitamin D3 and a dialysate calcium concentration of 1.375 mmol/l was compared with the response to treatment with a dialysate calcium concentration of 1.375 or 1.75 mmol/l alone over a 6 month period. In patients treated with 1alpha-hydroxyvitamin D3 there was a significant rise in plasma calcium associated with a significant fall in plasma alkaline phosphatase and plasma parathyroid hormone as well as resolution of sub-periosteal erosions. In these patients there was a significant rise in the calcium content of the forearm assessed by neutron activation analysis in comparison to patients treated with a dialysate calcium concentration of 1.75 or 1.375 mmol/l alone. In patients treated with a dialysate calcium concentration of 1.375 or 1.75 mmol/l alone there was no significant change in the plasma calcium, alkaline phosphatase or parathyroid hormone after 6 months and in these patients subperiosteal erosions either did not change or became worse. No significant difference in the response in these two groups was observed. This study indicates that treatment of haemodialysis patients with 1alpha-hydroxyvitamin D3 is significantly more effective than treatment with a dialysate calcium concentration of 1.375 or 1.75 mmol/l alone in preventing progression of hyperparathyroidism and skeletal calcium loss.
Cancer and the renin angiotensin system (RAS): Substantial activation as evidenced by quantification of various RAS peptides and their metabolites in plasma by LC-MS. (2011)

e21171 Background: The RAS is known for regulation of blood pressure. However, an activated RAS also supports tumor growth, in particular by its effector peptide Ang II. Elevated Ang II levels were found in plasma and malignant effusions of cancer patients (Samonigg et al. ASCO 2010). We have developed a sensitive LC-MS method to quantify plasma levels of all relevant peptides of the RAS. Utilization of this method for analysis of plasma of cancer patients, resulting in a “RAS peptide fingerprint” gives insight into the activation pattern of the RAS and may be utilized as guidance for novel therapies that re-balance an activated RAS, thereby reverting a tumor growth-promoting environment. Methods: A sensitive method based on LC-MS was developed to quantify Ang peptides and metabolites in plasma in a single run. Plasma was obtained from various patients with solid cancers in advanced stage and levels of Ang I, Ang II, Ang III, Ang IV, Ang1-9, Ang1-7, Ang2-7, Ang3-7 and Ang1-5 assessed. Respective results found in 21 healthy volunteers served as comparison. Results: In all analysed cancer patients (n=13) an activated RAS was seen. Substantially elevated Ang peptide plasma levels were found (in pg/ml): Ang I: mean 1.900, range 90-12.000 (mean healthy 17); Ang II: mean 350, range 5-2.100 (mean healthy 8); Ang1-9: mean 22, range 3-160 (mean healthy 3) Ang1-7: mean 45, range 5-250 (mean healthy 3); Ang1-5: mean 23, range 2-120 (mean healthy 2). Conclusions: Ang peptide levels in cancer patients were massively elevated when compared to healthy controls (up to 100-fold). Highly elevated levels were found for the effector peptide Ang II and its precursor Ang I, indicating overactivity of Renin and ACE. Degradation products of Ang II such as Ang1-7 and Ang1-5 were also elevated. Interestingly, the activation of the RAS did not have obvious impact on blood pressure. Based on these results, a novel therapeutic modality against cancer may consist in re-balancing an activated RAS. In this regard, treatment of cancer patients with recombinant human ACE2 (which efficiently degrades Ang II to Ang1-7 and is in clinical development against diseases with an imbalanced RAS) may be considered.
Amphibious Uncrewed Ground Vehicle for Coastal Surfzone Survey (2023)

The capability of a commercial off-the-shelf amphibious bottom crawling robot is explored for surveying seamless topography and bathymetry across the beachface, surfzone, and very nearshore. A real-time-kinematic (RTK) antenna on a mast was added to the robotic platform, a Bayonet-350 (previously the C2i SeaOx). Data collected from the robot were compared with those collected by the Coastal Research Amphibious Buggy (CRAB) and the Lighter Amphibious Resupply Cargo (LARC), unique amphibious vessels capable of collecting seamless topography and bathymetry in use for decades at the US Army Engineer Research and Development Center’s Field Research Facility (FRF). Data were compared on five different days in a range of wave conditions (Hs<1 m in 8-m depth) resulting in a root-mean square difference of 8.7 cm and bias of 2 cm for 24 different cross-shore profile comparisons. Additionally, a repeatability test was performed to asses measurement uncertainty. The repeatability test indicated a total vertical uncertainty (TVU) of 5.8 cm, with the highest spatial error at the shoreline.
Photocatalytic properties of In203 and In2S3 for hydrogen production and CO2 reduction (2012)

International @ EAU+DLO:EPU
Hub-based Personal Web-Enabled Cross-Device Application (2017)

As the Internet of Things has emerged, it has become possible to develop applications and services through various types of input / output using things as well as various graphic displays. In view of the development of such interfaces, a distributed user interface (DUI) is emerging in which a plurality of devices are simultaneously used to utilize one application service. In order to activate a DUI-based application, a method for the user to organize a users devices into groups and a methodology for service providers to describe their services in the form of DUI should be presented. We propose a hub-based personal web cross-device application framework. The framework consists of a server side markup language extension, a front end library, and a hub system that are implemented through a web-based browser simulator. We expect this framework to be applied as a browser feature so that DUI can provide a better user experience.
Automated measurements of gas‐liquid mass transfer in micropacked bed reactors (2017)

Gas‐liquid mass transfer in micropacked bed reactors is characterized with an automated platform integrated with in‐line Fourier transform infrared spectroscopy. This setup enables screening of a multidimensional parameter space underlying absorption with chemical reaction. Volumetric gas‐liquid mass‐transfer coefficients (k L a) are determined for the model reaction of CO 2 absorption in a methyl diethanolamine/water solution. Parametric studies are conducted varying gas and liquid superficial velocities, packed bed dimensions and packing particle sizes. The results show that k L a values are in the range of 0.12∼0.39 s −1 , which is about one‐to‐two orders of magnitude larger than those of conventional trickle beds. An empirical correlation predicts k L a in micropacked bed reactors in good agreement with experimental data . © 2017 American Institute of Chemical Engineers AIChE J , 64: 564–570, 2018
Transmission over multiple component carriers in LTE-A uplink (2011)

Long Term Evolution - Advanced systems are currently being standardized by 3GPP and aim at very high peak data rates of 1 Gb/s in the downlink and 500 Mb/s in the uplink. Those ambitious targets can only be achieved by using advanced MIMO antenna techniques as well as wide spectrum allocation, up to 100 MHz. A multiple component carrier structure has been agreed on in the 3GPP Work Item as a solution to extend the 18 MHz bandwidth of the previous LTE Release 8 up to 100 MHz. The multiple access schemes on both uplink and downlink now have to be adapted to the new spectrum configuration. Furthermore, in the link adaptation design the transmission over multiple CCs would reasonably lead to an increase of the feedback overhead. Bundling of the spatial or frequency parameters can keep the overhead low at the cost of lower throughput. In this article, we consider as a study case the LTE-A uplink, where NxDFT-spread- OFDM has been selected as the multiple access scheme. The validity of this scheme for the uplink is evaluated in terms of cubic metric, which is an indicator of the power de-rating needed at the transmitter to avoid intermodulation distortion. Furthermore, the impact of bundling the link adaptation parameters on the link performance is discussed considering both linear and turbo successive interference cancellation (SIC) receivers. Two codeword mixing stategies in the frequency and spatial domains are also proposed to boost the performance when the bundling is made per antenna or per CC, respectively. Results show that when a linear receiver is used in the base station, mixing techniques can increase spectral efficiency, thus reducing the performance gap to the no bundling case, which is the most expensive solution in terms of feedback signaling. However, when a turbo SIC receiver is used, only mixing over CCs is a valid option to achieve link performance gain.
Variational learning in mixed-state dynamic graphical models (1999)

Many real-valued stochastic time-series are locally linear (Gaussian), but globally nonlinear. For example, the trajectory of a human hand gesture can be viewed as a linear dynamic system driven by a nonlinear dynamic system that represents muscle actions. We present a mixed-state dynamic graphical model in which a hidden Markov model drives a linear dynamic system. This combination allows us to model both the discrete and continuous causes of trajectories suchas human gestures. The number of computations needed for exact inference is exponential in the sequence length, so we derive an approximate variational inference technique that can also be used to learn the parameters of the discrete and continuous models. We showhow the mixed-state model and the variational technique can be used to classify human hand gestures made with a computer mouse.
Extensive multiregional urea elevations in a case-control study of vascular dementia point toward a novel shared mechanism of disease amongst the age-related dementias (2023)

Taken together, these data not only describe a multiregional elevation of brain-urea levels in VaD but also imply the existence of a common urea-mediated disease mechanism that is now known to be present in at least four of the main age-related dementias.
Cascading plasmonic and nonradiative energy transfer interactions by plasmon-coupling only donor or only acceptor quantum dots of the energy transfer pairs (2010)

Here we present the first proposition and demonstration of cascaded plasmonic and nonradiative energy transfer interactions that are controlled by selectively plasmon-coupling either only donor nanocrystals (NCs), also known as semiconductor quantum dots, or only acceptor NCs of the energy transfer pairs. This scheme uniquely allows for the ability to spatially control plasmon-exciton interactions to take place either at the "start" site (donors) or "finish" site (acceptors) of the energy transfer. We also comparatively study and analyze consequent modifications of NC emission kinetics in response to both cases of plasmon-coupling to only the donor NCs and to only the acceptor NCs through steady-state and time-resolved photoluminescence measurements, along with their lifetime and rate calculations. Also, donor (D) and acceptor (A) NCs made of CdTe are carefully synthesized in different sizes to tune the spectral overlap between donor emission and acceptor absorption as well as to match the plasmon resonance of metal nanoparticles (MNPs).
Useful GIS tools in defining forest accessibility (2023)

Svrha ovog članka detaljno je pojašnjenje problematike funkcionalnog pristupa utvrđivanja dostupnosti šumske površine, odnosno jednoznačnog i ujednačenog utvrđivanja gustoće cesta i relativne otvorenosti promatrane šumske površine koja se najčešće prikazuje na razini gospodarske jedinice. Navedena dva parametra predstavljaju neizostavne čimbenike u kasnijoj fazi planiranja optimalne mreže šumskih prometnica. Kao vodič postupka otvaranja šuma poslužio je važeći Pravilnik o provedbi mjere M04 »Ulaganja u fizičku imovinu«, podmjere 4.3. »Potpora za ulaganja u infrastrukturu vezano uz razvoj, modernizaciju i prilagodbu poljoprivrede i šumarstva«, tipa operacije 4.3.3. »Ulaganje u šumsku infrastrukturu« iz Programa ruralnog razvoja Republike Hrvatske za razdoblje 2014. – 2020. (NN 106/2015, 65/2017, 77/2017 i 84/2018), koji propisuje način izrade Elaborata učinkovitosti mreže šumskih prometnica – primarne šumske prometne infrastrukture. U ovome radu prikazani su korisni alati unutar dva najzastupljenija GIS programska paketa: komercijalnog ArcGIS programa te besplatnog QGIS programa (eng. open source ). Detaljno su prikazani i pojašnjeni GIS alati unutar oba programa, a koji mogu pomoći pri izradi Elaborata učinkovitosti mreže šumskih prometnica – primarne šumske prometne infrastrukture. Ovaj stručni rad sadrži korisne informacije za sve koji se bave problematikom utvrđivanja dostupnosti šumske površine, odnosno optimalnog planiranja šumskih cesta, te za utvrđivanje stvarnog stanja gustoće cesta i relativne otvorenosti šuma kojom gospodare.
Purification and comparison of outer membrane protein P2 from Haemophilus influenzae type b isolates. (1983)

Haemophilus influenzae type b isolates have been subdivided based on differences in major outer membrane protein (OMP) profiles resolved on gradient and modified Laemmli sodium dodecyl sulfate-polyacrylamide gel electrophoresis systems. Although 21 subtypes have been observed, 86% of invasive isolates have one of five common subtypes and 71% of isolates have one of three subtypes. In isolates with two of the most common outer membrane subtypes, one major OMP has an apparent molecular weight of 37,000. In isolates with another common OMP subtype, a cross-reactive protein with an apparent molecular weight of 36,500 is observed. All three proteins have been designated P2. Protein P2 from these prototype isolates was solubilized with Zwittergent 3-14 and purified to homogeneity. Based on amino acid compositions, cyanogen bromide cleavage products, staphylococcal V8 protease, and chymotryptic peptide maps, the P2 protein from the three isolates has been highly conserved. Rabbit antibody prepared against P2 from one strain was cross-reactive with P2 isolated from the other two heterologous strains by Western blot. This antibody passively protected infant rats against type b Haemophilus infection caused by the homologous organism, but not against challenge by a strain with the heterologous 36,500 mol wt P2 protein. Thus, although the P2 protein from isolates with different OMP subtypes are closely related, the protection experiments suggest that determinants on the cell surface interacting with protective antibody may be strain or subtype specific.