gebhart/patrepeval huggingface dataset:
Inhibition of Gastric H+,K+-ATPase by 3-Amino-5-methyl-2-(2-methyl-3-thienyl)imidazo[1,2-α]thieno[3,2-c]pyridine, SPI-447 (1997)

We investigated the effect of a newly synthesized compound, 3-amino-5-methyl-2-(2-methyl-3-thienyl)imidazo[1,2-a]thieno[3,2-c]pyridi ne (SPI-447), on the activity of H+,K+-ATPase isolated from porcine gastric mucosa. In lyophilized gastric vesicles, SPI-447 inhibited K+-stimulated ATPase activity in a dose-dependent manner in a pH 7.4 solution (IC50=4.2 microM (1.05-16.8)). The inhibitory action of SPI-447 was enhanced at pH 6.8 (IC50=1.05 microM (0.31-3.57)) and not influenced by glutathione. In intact gastric vesicles, SPI-447 had no effect on the spontaneous diffusion of H+ across the microsomal membrane. These results indicate that SPI-447 directly inhibits gastric H+,K+-ATPase activity in a SH group-independent manner.
Extensive Junctional Diversity of Ig Heavy Chain Rearrangements Generated in the Progeny of Single Fetal Multipotent Hematopoietic Cells in the Absence of Selection (1998)

We analyzed the progeny of individual multipotent hemopoietic cells, derived from the para-aortic splanchopleura, the earliest identified source of lymphocyte precursors in pre-liver mouse embryos. Single precursors were expanded in an in vitro culture system that permits both commitment and differentiation of B cell precursors. We show that from one single multipotent progenitor we could obtain large numbers of B cell precursors that rearrange the Ig heavy chain genes and generate a repertoire as diverse as that observed in adult populations. N region additions are present at V(D)J junctions, showing that terminal deoxynucleotidyl transferase expression has been switched on and is not, consequently, an intrinsic property of adult stem cells. Throughout the culture period, cells show a majority of DJ vs V(D)J rearrangements and a ratio of 2:1 of nonproductive to productive V(D)J rearrangements, which is close to the expected frequency in the absence of selection. In addition, counterselection for D-J rearrangements in reading frame 2 is observed in V(D)J joints, and allelic exclusion was consistently observed. We conclude that of the three events associated with heavy chain rearrangement, two of them, namely allelic exclusion and counterselection of cells in which the D segment is in reading frame 2, are intrinsic to the cell, while selection of productive heavy chain rearrangements is induced in the bone marrow environment.
Evolution of Clinical and Electrophysiological Data in Children with a Preexcitation Syndrome (2016)

There were no significant changes of data in children after 6.3 ± 4.8 years of follow-up. Most children with spontaneous/inducible AVRTs at initial EPS had still inducible AVRT at second EPS. Induced AF conducted with high rate has a relatively low prognostic value for the prediction of adverse events.
Berechnung der Blitztemperaturen der Mikrokontakte in künstlichen Hüftgelenken unter Benutzung des Kontaktmodells von Greenwood – Williamson (2002)

Die Verwendung von Kugelköpfen und Pfannen aus Aluminiumoxidkeramik reduziert die Abriebrate beim Hüftgelenkersatz. Der klinische Einsatz von Zirkonoxidkeramiken (Y-TZP) wird kontrovers diskutiert. Die Vorgänge an den Artikulationsflächen Kopf/Pfanne sind nicht vollständig verstanden, besonders die durch Reibwärme verursachte Temperaturerhöhung. Bei den phasenstabilen Aluminiumoxidkeramiken werden keine ungünstigen Effekte beobachtet. Bei Y-TZP dagegen kann durch reibbedingte Temperaturerhöhungen die Gerinnungstemperatur der Gelenkflüssigkeit überschritten, bzw. die Phasenumwandlung des Y-TZP ausgelöst werden. Mit Hilfe des Modells von Kuhlmann – Wilsdorf sind unter in vivo Randbedingungen die Blitztemperaturen in den Mikrokontakten der verschiedenen keramischen Artikulationspartner bestimmt worden. Die zugehörigen realen Kontaktbedingungen wurden mit den analytischen Modellvorstellungen nach Grennwood – Williamson berechnet. Die Oberflächentemperaturen sind für die Gleitpaarung Y-TZP/Y-TZP höher als für Al2O3/Al2O3. Calculation of Flash Temperatures of Micro-Contacts in Artificial Hip Joints by Using the Contact Model of Greenwood – Williamson In hip replacement the wear rate is reduced when using femoral heads and acetabular cups made of alumina ceramics. The use of zirconia ceramics (Y-TZP) is discussed controversy. The process on the articulating surfaces head / cup are not totally understood, especially the temperature rise due to frictional heating. Alumina is a stable material, no problems are expected. When using Y-TZP, friction temperature can be higher then the coagulate temperature of synovia or the phase transition is induced. The model proposed by Kuhlmann – Wilsdorf was used to calculate the flash temperature under in vivo conditions of micro-contacts at the different articulating surfaces. The real contact conditions were calculated with the analytical contact model of Greenwood – Williamson. The surface temperature of the wear couple Y-TZP/Y-TZP was higher than the one for alumina/alumina.
Identification of Inhibitors of Checkpoint Kinase 1 through Template Screening (2009)

Checkpoint kinase 1 (CHK1) is an oncology target of significant current interest. Inhibition of CHK1 abrogates DNA damage-induced cell cycle checkpoints and sensitizes p53 deficient cancer cells to genotoxic therapies. Using template screening, a fragment-based approach to small molecule hit generation, we have identified multiple CHK1 inhibitor scaffolds suitable for further optimization. The sequential combination of in silico low molecular weight template selection, a high concentration biochemical assay and hit validation through protein-ligand X-ray crystallography provided 13 template hits from an initial in silico screening library of ca. 15000 compounds. The use of appropriate counter-screening to rule out nonspecific aggregation by test compounds was essential for optimum performance of the high concentration bioassay. One low molecular weight, weakly active purine template hit was progressed by iterative structure-based design to give submicromolar pyrazolopyridines with good ligand efficiency and appropriate CHK1-mediated cellular activity in HT29 colon cancer cells.
ChemInform Abstract: Inhibitors of MMP‐1: An Examination of P′ 1 Cα gem‐ Disubstitution in the N‐Carboxyalkylamine and Glutaramide Carboxylate Series. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dataset for: CORNERSTONE's silicon photonics rapid prototyping platforms: Current status and future outlook (2020)

Dataset for CORNERSTONE’s silicon photonics rapid prototyping platforms: Current status and future outlook published in Applied Sciences.
Momentum-space polarization fields in two-dimensional photonic-crystal slabs: Physics and applications (2022)

In addition to non-radiative guided modes, two-dimensional photonic-crystal slabs support guided resonant ones which can radiate into free space. From the polarization states of these guided resonances, a polarization field on a photonic band can be constructed in momentum space. Momentum-space polarization fields display complicated configurations and patterns with different types of polarization singularities inside, shedding new light on the manipulations of light flows. In this review, we summarize the recent research progress on momentum-space polarization fields and singularities in two-dimensional photonic-crystal slabs, focusing on their unique optical properties and potential applications as well.
trans‐Directing Ability of Amide Groups in Cyclopropanation: Application to the Asymmetric Cyclopropanation of Alkenes with Diazo Reagents Bearing Two Carboxy Groups (2008)

Highly stereoselective: A highly enantioselective (up to 97 % ee) and diastereoselective (>30:1 d.r.) RhII-catalyzed cyclopropanation of alkenes using a diazo reagent bearing two carboxy groups is described. This new methodology exploits the powerful trans-directing ability of amides to improve enantiocontrol. Mono- and disubstituted olefins are cyclopropanated in good yields. nttl=N-1,8-naphthoyl-tert-leucine. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Burden of atopic dermatitis in Japanese adults: Analysis of data from the 2013 National Health and Wellness Survey (2018)

Atopic dermatitis is a chronic inflammatory skin disease. The objective of this study was to characterize the burden of atopic dermatitis in Japanese adult patients relative to the general population. Japanese adults (≥18 years) with a self-reported diagnosis of atopic dermatitis and adult controls without atopic dermatitis/eczema/dermatitis were identified from the 2013 Japan National Health and Wellness Survey. Atopic dermatitis patients were propensity-score matched with non-atopic dermatitis controls (1:2 ratio) on demographic variables. Patient-reported outcome data on comorbidities, mood and sleep disorders, health-related quality of life, work productivity and activity impairment, and health-care resource utilization were analyzed in atopic dermatitis patients and matched controls. A total of 638 Japanese adult patients with atopic dermatitis were identified, of whom 290 (45.5%) rated their disease as "moderate/severe" and 348 (54.5%) as "mild". The analysis cohort comprised 634 atopic dermatitis patients and 1268 matched controls. Atopic dermatitis patients reported a significantly higher prevalence of arthritis, asthma, nasal allergies/hay fever, anxiety, depression and sleep disorders compared with controls (all P < 0.001). Atopic dermatitis patients also reported a significantly poorer health-related quality of life, higher overall work and activity impairment, and higher health-care resource utilization (all P < 0.001). Self-rated disease severity was not associated with disease burden, except for a significantly higher overall work and activity impairment. In conclusion, Japanese adult patients with atopic dermatitis reported a substantial disease burden relative to adults without atopic dermatitis, suggesting an unmet need for effective strategies targeting disease management.
Experimental XPM, SPM, FWM penalty evaluation in very dense WDM optical systems (2005)

Experimental SPM, FWM and XPM contributions are separately measured. Evaluation of Q penalties is performed on a 2000-km, 33-GHz, 66-GHz and 100-GHz-spaced DWDM system. XPM is found to be the major constrain.
Effects of starvation and refeeding on the excretion of urinary steroid metabolites in mice with different genetic background. (1984)

Gas chromatographic steroid metabolic profiling procedures have been applied to investigations of the effects of starvation and refeeding in mice. Urinary steroid metabolites were quantitatively followed during the starvation-refeeding experiments for mice with different genetic backgrounds. Some quantitative alterations were noted for certain congenic strains of mice. The metabolites which exhibited such quantitative variations were tentatively identified by means of combined gas chromatography-mass spectrometry.
Patterning of GexSbxTey for non volatile phase-change memory applications (2012)

International audience
All-Electronic 100-GHz Bandwidth Digital-to-Analog Converter Generating PAM Signals up to 190 GBaud (2016)

We demonstrate an all-electronic digital-to-analog converter (DAC) with 100-GHz electrical bandwidth, sampling at 240 GSa/s, based on digital band interleaving (DBI). We discuss digital predistortion techniques for compensating the nonideal performance of the high-speed and radio-frequency components in our DBI architecture. We then test the DAC by generating up to 190-GBaud Nyquist-shaped pulse amplitude modulation. We analyze the performance of the digital band interleaved DAC and demonstrate coherent detection of single-polarization optical binary phase-shift keying at 140 GBaud.
Diameter dependent Raman scattering of WS2 nanotubes (2009)

Abstract The effect of the tube diameter and of the surface layer on the Raman spectra of WS 2 nanotubes is investigated. With decreasing diameter, a disorder‐induced line in the A 1g mode range, the D‐A 1g line, is selectively enhanced. This enhancement is attributed to an increasing structural disorder in smaller nanotubes. On the other hand, no significant effect on the D‐A 1g /A 1g intensity ratio is observed for a Raman scan perpendicular to a 290 nm diameter tube. Therefore the enhancement of the disorder‐induced line is an intrinsic property of WS 2 nanostructures and not a surface layer effect.
Preoperative sonographic axillary staging in breast cancer: correlation with sentinel node sampling (2011)

The automated breast volume scanner (ABVS) is the fi rst of its kind and utilises a large, 17 cm 15 cm high-frequency ultrasound probe which sweeps across the whole breast generating images that can be reformatted into multiple planes and a 3D volume. ABVS will change breast ultrasound practice by: introducing operator standardisation, reproducibility and repeatability of measurement and interpretation; changing who acquires the volume set and how breast ultrasounds are reported; and allowing accurate comparison of previous and current examinations for screening and assessing treatment change. Methods Patients presented to the symptomatic clinic for conventional 2D ultrasound assessment with a variety of conditions. An additional ABVS was performed. Results Cases were classifi ed into: benign -for example, cysts, fi broadenomas, diabetic mastopathy; and malignant.
Microwave phase detection for angle of arrival detection using a 4-channel optical downconverter (2002)

Fiber optic links maintain an advantage over traditional microwave transmit and receive systems in terms of multi-octave operation and RF isolation, and the ability to remote microwave signals great distances. For the first time, a 4-channel optical downconverter capable of detecting the relative microwave phase of incoming microwave signals up to 18 GHz is tested. The phase information can be related to angle of arrival detection. We present the first results of a 4-channel remotable optical downconverter used for phase detection of incoming signals up to 18 GHz. The phase information is related to angle of arrival detection.
SFCMon: An Efficient and Scalable Monitoring System for Network Flows in SFC-enabled Domains (2019)

A comprehensive monitoring system is essential to assist solutions for most of SFC problems. Therefore, in this work, we propose SFCMon, an efficient and scalable monitoring solution to keep track network flows in SFC environments. To achieve the desired goals, SFCMon works with a pipeline of probabilistic data structures to detect and store large flows as well as perflow counters. For evaluation purposes, based on the SFC reference architecture defined by RFC 7665, we implement a Proof-of-Concept (PoC) framework, which provides a P4-based SFC switch and Python-based SFC Controller. Presented initial experiments demonstrate that SFCMon introduces a negligible performance penalty while providing significant scalability gains.
Closed loop transmission with precoding selection in LTE/LTE-Advanced system (2010)

Closed-loop transmission combined with MIMO (multiple-input multiple-output) and OFDM (orthogonal frequency division multiplexing) technologies have drawn most attentions during development of the 4G systems (fourth generation of mobile communication systems). In LTE (Long Term Evolution) and LTE-Advanced systems, which are proposed by 3GPP (Third Generation Partnership Project) to be the most competitive candidate for the 4G systems, the codebook based precoding scheme is deployed for realizing the closed-loop transmission concept. This scheme introduces the precoding matrix selection at the receiver and precoding operation at the transmitter and achieves a good tradeoff between the system complexity and the performance gain given by the closed-loop transmission. In this manuscript, the authors give a brief overview of the LTE/LTE-Advanced system downlink transmission. Furthermore, different precoding matrix selection criteria are discussed at the aim of optimal receiver design. Following the analytical and numerical results, the authors conclude that the minimum post mean squared error based criterion is the optimal candidate for precoding matrix selection at the receiver in LTE compliant systems.
Non-invasive management of infants with SFTPC pathogenic variants (2023)

Pathogenic variants in the Surfactant Protein C gene ( SFTPC ) result in fibrotic childhood interstitial lung disease (chILD). We previously reported three children with SFTPC pathogenic variants with respiratory failure who were supported by chronic invasive ventilation via tracheostomy as an alternative to lung transplantation or comfort care [(1)](#ref-0001). We present two children with SFTPC pathogenic variants treated with non-invasive ventilation (NIV) (Figure 1).
Key Generation Techniques to Ensure User Data Integrity in Cloud Environments (2018)

Background/Objectives: Cloud services are becoming popular with many users as they provide services based on the Internet. Users who use cloud services can integrate computing resources such as hardware and software, which exist in intangible form, through virtualization technology, and there is a great demand for security technologies related to security problems.Methods/Statistical analysis: As a result of the evaluation, the proposed method in the security evaluation and the performance evaluation resulted in better data integrity and security than the existing method. In addition, we checked the integrity of different cloud data and obtained the efficiency improved by O (logn) than the existing method.Findings: In this paper, we propose a robust data integrity protection scheme for various security attacks in the cloud environment. The proposed method effectively guarantees the integrity of the data used by the user through the generation and processing of low-load keys between the TPA, the user and the KGC. To protect the integrity of the data transmitted and received in the cloud environment, the proposed method generates the key through three processes (data generation process, encryption key generation process, and metadata attribute key pair generation process).Improvements/Applications: The key generated in this process is used by the anonymous key so that sensitive information of the cloud user is not exposed to a third party so that the important information of the user is not remembered. In addition, the proposed scheme keeps synchronization between the TPA and the user at a predetermined time interval so that the important information of the user is not illegally exploited from the third party.Â Â
Proceedings of the 29th annual international ACM SIGIR conference on Research and development in information retrieval (2006)

We are pleased to report that on this 29th Anniversary of SIGIR, the Conference of Research and Development on Information Retrieval has attracted a record-breaking number of papers. There were 399 paper submissions representing the work of IR researchers in more than 35 countries. Seventy four (18.5%) of the submitted papers were accepted, representing the different geographic areas as follows: 49 from the Americas, 11 from Europe and 14 from Asia - Pacific. In addition to the full papers, 63 posters, 11 demonstrations, 8 tutorials and 9 workshops were accepted for inclusion in the technical program. A doctoral consortium with 9 PhD candidates is also part of the technical program. It is also worth noting that more than half of the accepted papers have a student as the first author, an encouraging sign for the growth and vitality of the community. The contributions in these proceedings represent a diverse and comprehensive coverage of IR research including theoretical models, techniques related to specific tasks (e.g. filtering, summarization, text categorization, question answering, and indexing), system performance, approaches to query formulation, retrieval in different environments (e.g. the Web, the enterprise, the desktop, multilingual, and multimedia), evaluation, and user studies.The selection of quality contributions for the SIGIR conference is dependent on a robust and equitable two tier reviewing process. The PC Chairs and 30 area coordinators for the 13 main topic areas in the call for papers, nominated nearly 250 primary reviewers. Each reviewer was semi-automatically assigned between 3 and 8 papers by the PC chairs in accordance to reviewers' stated subject expertise and each paper was allocated three reviewers. In cases where there was a wide range of scores or incomplete information, several primary reviewers helped us out with a number of additional reviews. The role of the area coordinators was to oversee the process for their topic area, by resolving disagreements between reviewers and producing a meta review for each paper drawn from the primary reviews. The meta reviews served as the basis of discussion at the Programme Committee meeting. Most area coordinators were responsible for 15 or more papers / meta reviews, and some bravely represented nearly 30 papers at the PC meeting, when a colleague was taken ill. Area coordinators were selected for their subject expertise in the different topic areas and attention was also paid to geographic representation and PC Committee experience. All the reviewing was double blind with the identity of authors being released only after the selection of papers was completed.
High critical currents in Y-Ba-Cu-O films on silicon using YSZ buffer layers (1991)

Exceptionally high-quality films of Y/sub 1/Ba/sub 2/Cu/sub 3/O/sub 7-x/ (YBCO) were successfully grown epitaxially on Si
Control and modulation of the stacked polyphase bridges inverter (2014)

In order to meet the requirements of future electric vehicle (EV) drive systems, new converter topologies are required. The stacked polyphase bridges (SPB) inverter is a new topology which is well adapted to the needs for future EVs [1]. In addition to low power losses, the SPB inverter also has fault tolerance ability and good dynamic behavior. This paper presents a further analysis of the control and modulation concept of the SPB inverter. Simulation results are used to verify the analysis conclusions.
Prevalence, severity, and risk factors for acute exacerbations of nasal and sinus symptoms by chronic rhinosinusitis status (2018)

In this first longitudinal, population-based study of 3 AENSS definitions, NSS and AENSS were both common, sometimes severe, and differed by EPOS<sub>S</sub> CRS status. Contrasting associations of risk factors for AENSS by the different definitions suggest a need for a standardized approach to definition of AENSS.
Prediction of Semiconductor Material Properties by the Properties of Their Constituent Chemical Elements (2000)

We demonstrate that it is possible to predict the semiconductor material properties, like lattice constant and band gap energy, from their chemical stoichiometries and fundamental element properties of the constituents. We use a correlation technique to show that band gap energy is strongly correlated to electronegativity and pseudopotential radii whereas the lattice constant is strongly correlated to melting temperature and atomic number. Prediction of band gap energy and lattice constant of some III−V and II−VI semiconductors is made on the basis of the developed correlation model. The technique can also be applied to predict bulk properties of ternary or quaternary semiconductors.