gebhart/patrepeval huggingface dataset:
Luminescent Polycrystalline Cadmium Selenide Nanowires Synthesized by Cyclic Electrodeposition/Stripping Coupled with Step Edge Decoration (2006)

Cadmium selenide (CdSe) nanowires, 30−300 nm in diameter, were synthesized using electrochemical step edge decoration on highly oriented pyrolytic graphite (HOPG) surfaces. These CdSe nanowires were more than 100 μm in length and were organized into parallel arrays of hundreds following the length and organization of the HOPG step edges used to nucleate these nanowires. The synthesis of CdSe nanowires involved a method derived from the cyclic electrodeposition/stripping scheme described by Sailor and co-workers (Chem. Mater. 1991, 3, 1015). Stoichiometric CdSe was obtained by electrodepositing CdSe together with excess elemental cadmium and selenium, followed by the selective oxidative stripping of both excess cadmium and selenium from these nanowires. This synthesis method also afforded precise control of the nanowire diameter over the above-mentioned range. CdSe nanowires were characterized by scanning electron microscopy, transmission electron microscopy (TEM), selected area electron diffraction, photoluminescence, X-ray photoelectron spectroscopy, and Raman spectroscopy. The TEM results showed that the CdSe nanowires were composed of nanocrystalline, cubic CdSe with a crystallite size that decreased with increasing pH. CdSe nanowires showed band edge photoluminescence at 1.74 eV that increased in intensity by a factor of 15 when these wires were covered by a shell of CdS by exposure to gaseous H2S at 300 °C.
Fault detection, real-time error recovery, and experimental demonstration for digital microfluidic biochips (2013)

Advances in digital microfluidics and integrated sensing hold promise for a new generation of droplet-based biochips that can perform multiplexed assays to determine the identity of target molecules. Despite these benefits, defects and erroneous fluidic operations remain a major barrier to the adoption and deployment of these devices. We describe the first integrated demonstration of cyberphysical coupling in digital microfluidics, whereby errors in droplet transportation on the digital microfluidic platform are detected using capacitive sensors, the test outcome is interpreted by control hardware, and software-based error recovery is accomplished using dynamic reconfiguration. The hardware/software interface is realized through seamless interaction between control software, an off-the-shelf microcontroller and a frequency divider implemented on an FPGA. Experimental results are reported for a fabricated silicon device and links to videos are provided for the first-ever experimental demonstration of cyberphysical coupling and dynamic error recovery in digital microfluidic biochips.
CYP11A1 inhibition as a therapeutic approach for the treatment of castration resistant prostate cancer (2018)

Background: Prostate cancer is a major global challenge due to the increasing number of aging population and frequency of diagnosis. During the past decade new treatments have been targeted to the androgen signaling axis either by inhibiting the binding of androgens to androgen receptor (AR) and AR nuclear translocation, or by inhibiting androgen production via CYP17A1 enzyme. Despite the significant progress on the research and new therapies, CRPC is still incurable and there is urgent need for better, more effective treatments. ODM-208 is an oral, non-steroidal and selective inhibitor of CYP11A1 enzyme, suppressing the synthesis of all steroid hormones that could be potential AR ligands. Methods: The inhibition of CYP11A1 was measured in vitro by the formation of radiolabelled isocapronic acid in a human adrenal cortex cell line (H295R). The tumor growth inhibition of ODM-208 was studied in VCaP CRPC xenograft model. Full length AR (AR-FL) and AR-V7 were analysed from the tumors by western blot and also key enzymes of androgen biosynthesis, CYP17A1, AKR1C3, SRD5A1 were quantified by qPCR. At the end of the xenograft study, plasma ACTH and LH, and key steroid hormone concentrations were analysed from plasma and target tissues. Results: ODM-208 potently inhibits CYP11A1 enzyme in vitro. In addition, in vivo in the VCaP CRPC xenograft model ODM-208 significantly inhibited tumor growth. Importantly, the amount of AR-FL and AR-V7 levels remained unchanged in the tumors after ODM-208 treatment. Slight increase of CYP17A1 and SRD5A1 enzyme levels was observed, indicating the activation of steroidogenesis in VCaP tumors in vivo. Treatment had no effect on plasma LH, whereas ACTH was significantly increased demonstrating reduction in glucocorticoid levels by negative feedback. In line with ACTH, all measured steroid hormones were significantly reduced both in plasma and target tissues. Conclusions: ODM-208 shows promising antitumor activity in preclinical CRPC models and has favorable toxicological profile. Thus, ODM-208 might have potential for treating patients with CRPC. Based on the nonclinical results, a phase 1/2 clinical trial (NTC03436485) has been initiated. Legal entity responsible for the study: Orion Corporation, Orion Pharma. Funding: Orion Corporation, Orion Pharma. Disclosure: R. Oksala, K. Räsänen, M. Karimaa, R. Riikonen, M. Ramela, P. Vehmaan-Kreula, O. Simola, P. Rummakko, G. Wohlfahrt, M. Mustonen: Employee: Orion Corporation.
Detection of Early Antiangiogenic Effects in Human Colon Adenocarcinoma Xenografts:In vivoChanges of Tumor Blood Volume in Response to Experimental VEGFR Tyrosine Kinase Inhibitor (2005)

Antiangiogenesis is emerging as efficient strategy for targeting and potentially eliminating neoplastic tumor vessels. The main goal of this study was to establish whether absolute tumor blood volume (V(b)) change could be used as an early predictor of antiangiogenesis in ectopic and orthotopic colon carcinomas. To assess therapy-induced changes of V(b), we did comparative analysis of signal intensities in tumors and muscle using steady-state magnetic resonance imaging (MRI) assisted with an intravascular paramagnetic contrast agent [gadolinium-labeled protected graft copolymer (PGC-Gd)]. Athymic mice with implanted human MV522 tumors were treated with vascular endothelial growth factor type 2 receptor tyrosine kinase inhibitor (VEGFR2-TKI) that has been shown to inhibit VEGFR2 phosphorylation and tumor growth in vivo. Animals were imaged either after a single day or after a 1-week course of treatments. The measured V(b) in ectopic tumors was 2.5 +/- 1.5% of total tissue volume 1 week after the implantation (n = 8). Two doses of VEGFR2-TKI (25 mg/kg, p.o., b.i.d.) resulted in a decrease of V(b) to 1.3 +/- 0.3%. In orthotopic tumors, the measured V(b) was initially higher (11.9 +/- 2.0%); however, VEGFR2-TKI treatment also resulted in a statistically significant decrease of V(b). The absolute V(b) was not affected in the muscle as a result of treatments. MRI measurements were corroborated by using isotope and correlative histology experiments. Our results show that steady-state MRI is highly sensitive to early antiangiogenic effects caused by small molecule drugs.
Prenatal exposure to recreational drugs affects global motion perception in preschool children (2015)

Prenatal exposure to recreational drugs impairs motor and cognitive development; however it is currently unknown whether visual brain areas are affected. To address this question, we investigated the effect of prenatal drug exposure on global motion perception, a behavioural measure of processing within the dorsal extrastriate visual cortex that is thought to be particularly vulnerable to abnormal neurodevelopment. Global motion perception was measured in one hundred and forty-five 4.5-year-old children who had been exposed to different combinations of methamphetamine, alcohol, nicotine and marijuana prior to birth and 25 unexposed children. Self-reported drug use by the mothers was verified by meconium analysis. We found that global motion perception was impaired by prenatal exposure to alcohol and improved significantly by exposure to marijuana. Exposure to both drugs prenatally had no effect. Other visual functions such as habitual visual acuity and stereoacuity were not affected by drug exposure. Prenatal exposure to methamphetamine did not influence visual function. Our results demonstrate that prenatal drug exposure can influence a behavioural measure of visual development, but that the effects are dependent on the specific drugs used during pregnancy.
2306 A multi-scale hemodynamic model of the cardiovascular system based on the coupling of ODEs and hyperbolic PDEs (2007)

The purpose of this study is to develop a multi-scale hemodynamic model capable of simulating wave propagation in the human cardiovascular system (CVS) in a closed-loop manner. For this purpose, a 0D model of the CVS and a 1D model of the arterial tree are constructed and merged via 0-1D hemodynamic coupling computation at the aortic inlet and the terminals of the arterial tree (interfaces). The resulting 0-1D multi-scale hemodynamic model is a closed-loop system, which resembles the in vivo closed-loop structure of the CVS. The blood pressure/flow waveforms simulated in various portions of the CVS are in reasonable agreements with the general clinical observations.
Splice variants of rat TR4 orphan receptor: differential expression of novel sequences in the 5'-untranslated region and C-terminal domain. (1996)

The use of rapid amplification of 5'-cDNA ends-PCR yielded two novel sequences for the rat orphan receptor, TR4, representing heterogeneity on the 5'-untranslated region. Genomic structure analysis revealed that the 5'-untranslated region of the longer messenger RNA fragment, rTR4-1, contained three exons, alpha, beta, and gamma. The skipping of exon gamma gave rise to rTR4-2, indicating that rTR4-1 and rTR4-2 are products of alternative splicing. We isolated another novel rat TR4 splice variant, rTR4-NS, which was found to diverge from rTR4-2 at codon 504. rTR4-NS contained an unspliced intronic sequence with in-frame codons for eight amino acids followed by a termination codon. The three TR4 messenger RNA variants were differentially expressed. rTR4-NS appeared to be a rare transcript found in limited areas of the brain. In situ hybridization detect prominent TR4 signals in brain areas known to be involved in stress response. In cerebellar granule cells, the rise in TR4 expression correlated with the progression of neuronal maturation. N-Methyl-D-aspartate treatment triggered a marked increase in TR4 expression. These results suggest a possible role for TR4 in neuronal differentiation.
Resolution Improvement In FZA Lens-Less Camera By Synthesizing Images Captured With Different Mask-Sensor Distances (2021)

Fresnel zone aperture (FZA) lens-less camera is a class of computational imaging systems that employs an FZA as a coded mask instead of an optical lens. FZA lens-less camera can perform fast deconvolution reconstruction and realize the re-focusing function. However, the reconstructed image’s spatial resolution is restricted by diffraction when using the conventional method derived from the geometrical optics model. In a previous study, we quantitatively analyzed the diffraction propagation between mask and sensor. Then we proposed a color-channel synthesis reconstruction method based on wave-optics theory. This study proposed a novel image reconstruction method without distorting the color information, comprehensively synthesizing two images captured with different mask-sensor distances to mitigate the diffraction influence and improve the image resolution. The numerical simulation and optical experiment results confirm that the proposed method can improve the spatial resolution to about two times that of the conventional method based on the geometrical optics model.
Manipulation of Discrete Nanostructures by Selective Modulation of Noncovalent Forces (2014)

Covalent organic synthesis commonly uses the strategy of selective bond cleavage and formation. If a similar approach can be applied stepwisely to noncovalent synthesis, more exotic or challenging nanostructures might become achievable. Here, we report that ferrocene-based tetratopic pyridyl ligands, which can dynamically change their geometry by means of thermal rotation of their cyclopentadienyl rings in solution, assemble with AgBF4 into discrete metal-organic nanotubes with large and uniform diameters. The nanotubes can be cut into metal-organic nanorings through selective attenuation of the inter-nanoring interaction via ferrocene oxidation. The resultant nanorings can be transferred onto inorganic substrates electrostatically or allowed to reassemble to form the original nanotube by the reductive neutralization of their oxidized ferrocene units.
Late neurological complications of Harrington-rod instrumentation. (1989)

From our patients who had idiopathic scoliosis, we identified a subset of eighteen in whom Harrington rods were used for fixation down to the fifth lumbar vertebra. In five of these patients, low-back pain, sciatica, and other neurological problems developed at two to thirty-two months after arthrodesis. These complications were caused by migration of the caudad hook into the spinal canal. The migration was probably caused by a combination of lumbosacral lordosis and mobility of the fifth lumbar vertebra (the most caudad mobile segment) on the segment below, resulting in weakening of the lamina of the fifth lumbar vertebra. After removal of the hardware, all patients had improvement of the lumbosacral and radicular pain as well as resolution of the neurological abnormalities.
PRMT5 is a novel cofactor of Foxp3 and can be a target for tumor immunotherapy (2016)

Abstract Regulatory T cells (Tregs) are a subpopulation of T cells specialized for suppressing host immune systems, whose dysfunction can lead to severe autoimmunity and inflammatory disease in humans and animals. In a tumor bearing host, an enhanced activity of Tregs may limit host immunity against tumor antigens. Our laboratory has studied the Foxp3 transcriptional complex at the molecular and atomic levels. We identified a protein arginine methyl transferase 5 (PRMT5) as a binding partner of Foxp3. Mice whose expression of PRMT5 was deleted in Tregs developed severe autoimmunity, scurfy like phenotypes and died at ~3 weeks of age. A limited number of Tregs were found in the spleen, but there were normal numbers of Tregs in the peripheral lymph nodes. Tregs that lacked PRMT5 displayed limited suppressive function when compared to wild type cells. Two types of PRMT5 inhibitors, EPZ004777 and EPZ015666, were studied to determine if inhibition of PRMT5 reduces human Treg functions. While EPZ004777 could inhibit human Treg functions in vitro, EPZ015666 had limited ability to limit these Treg activities. EPZ004777 could also inhibit the methylation of Foxp3. Injection of EPZ004777 to p185/erbB2/neu tumor bearing mice enhanced the effect of anti-erbB2/neu monoclonal antibody therapy. Furthermore, treatment with EPZ004777 reduced the numbers of tumor infiltrating Tregs, indicating that EPZ004777 functions by inhibiting Treg functions and/or migration of Tregs into p185 expressing tumors. These studies support the concept that controlling PRMT5 activity is a promising strategy in a p185 targeted monoclonal antibody therapy in which host immunity against tumors is augmented in a Foxp3 dependent manner.
Polymer protected reagents. III. Acetal formation with polymer protected aluminum chloride (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolymer protected reagents. III. Acetal formation with polymer protected aluminum chlorideE. C. Blossey, L. M. Turner, and D. C. NeckersCite this: J. Org. Chem. 1975, 40, 7, 959–960Publication Date (Print):April 1, 1975Publication History Published online1 May 2002Published inissue 1 April 1975https://pubs.acs.org/doi/10.1021/jo00895a037https://doi.org/10.1021/jo00895a037research-articleACS PublicationsRequest reuse permissionsArticle Views227Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Clonal T cell‐mediated cyclic thrombocytopenia (2002)

Cyclic thrombocytopenia is a rare disorder characterized by periodic platelet count fluctuations of unknown aetiology. We report on a female patient with cyclic changes of platelet counts ranging from 6 x 10(9)/l to 753 x 10(9)/l in 4-week intervals. Platelet counts were inversely correlated to thrombopoietin levels suggesting production failure. Reticulocyte counts and neutrophil counts showed similar, but less prominent, fluctuations. Clonal T-cell receptor rearrangement was detected in bone marrow samples as well as in peripheral blood. Cell typing of blood lymphocytes revealed a relative increase in CD3+ T cells. Treatment with cyclosporine A resulted in a substantial improvement of platelet counts. Taken together, we provide evidence for clonal T-cell mediated bone marrow failure with cyclic impairment of thrombopoiesis responsive to cyclosporine therapy.
Novel Air-gap Formation Technology Using Ru Barrier Metal for Cu Interconnects with High Reliability and Low Capacitance (2011)

A novel technology for obtaining low-capacitance Cu interconnects with air gaps has been proposed. Using a Ru barrier metal as a self-mask, a Cu interconnect was effectively protected from losing its cross-sectional shape during the intermetal dielectric etching process. The wiring capacitance with air-gaps was about 30% lower than that of the conventional low-k (k = 2.65)/Cu structure without air-gaps. The time-dependent dielectric breakdown (TDDB) lifetime of the air-gap interconnect with a Ru barrier was 100 times longer than that of the low-k/Cu structure. These results indicate that an air-gap interconnect with a Ru barrier metal can be an effective solution to boost the circuit operating speed and to reduce the power dissipation without the degradation of interconnect reliability for devices of 45 nm nodes and beyond.
Protein Aggregates and Novel Presenilin Gene Variants in Idiopathic Dilated Cardiomyopathy (2010)

On the basis of these findings, we propose that 2 mechanisms may link protein aggregation and cardiac function: oligomer-induced changes on Ca(2+) handling and a direct effect of PSEN1 sequence variants on excitation-contraction coupling protein function.
Techniques for characterizing DRAMs with a 500 MHz interface (2002)

The advent of high-bandwidth DRAMs poses a number of new challenges for test and characterization. This paper describes a collection of techniques that were used in the design and characterization of a new DRAM architecture with 500 MHz I/O signals. Methods of fixturing and calibration are presented for achieving system accuracies of better than 100 ps. Laboratory techniques for measuring critical circuit parameters such as path delay, clock jitter, current source strength, and pin capacitances are shown as well. These techniques, along with on-chip test logic, which allows the DRAM core to be tested using conventional low-speed memory test equipment, enable full characterization of high bandwidth memories.
Temporally interleaved optical time-stretch imaging (2020)

Optical time-stretch imaging has shown potential in diverse fields for its capability of acquiring images at high speed and high resolution. However, its wide application is hindered by the stringent requirement on the instrumentation hardware caused by the high-speed serial data stream. Here we demonstrate temporally interleaved optical time-stretch imaging that lowers the requirement without sacrificing the frame rate or spatial resolution by interleaving the high-speed data stream into multiple channels in the time domain. Its performance is validated with both a United States Air Force (USAF)-1951 resolution chart and a single-crystal diamond film. We achieve a 101 Mfps 1D scanning rate and 3 µm spatial resolution with only a 2.5 GS/s sampling rate by using a two-channel-interleaved system.
Endothelin-1 Gene Variant Associates With Blood Pressure in Obese Japanese Subjects (2001)

A recent report based on the results of 2 epidemiological studies, the Etude Cas-Temoin de l'Infarctus Myocarde (ECTIM) and the Glasgow Heart Scan Study, revealed that a G/T polymorphism with an amino acid substitution (Lys-->Asn) at codon 198 in exon 5 of the endothelin-1 gene (ET-1) is associated with blood pressure in overweight people. They suggested that G/T polymorphism of ET-1 strongly interacted with body mass index (BMI) in the determination of BP levels. To examine interaction among G/T polymorphism of ET-1, BMI, and BP, we performed an association study in a general Japanese population. Subjects (n=1250) were recruited from Ohasama, a cohort in a rural community of northern Japan. DNA was extracted from buffy coat of participants, and G/T polymorphism of ET-1 was determined by the TaqMan probe polymerase chain reaction method, a powerful tool for semiautomatic genotype determination of a large number of samples. Frequency of T (Asn 198) allele in Japanese (27%) was slightly but significantly higher than in whites (24%). Baseline characteristics (age, BMI, systolic and diastolic BP, and antihypertensive treatment) of all subjects were not significantly different according to the genotype of G/T polymorphism. However, in obese subjects (> or =25 kg/m(2)) diastolic BPs were significantly associated with G/T polymorphism of ET-1. After adjustment for confounding factors, significant association remained; for overweight subjects, diastolic BP level in those with T allele (GT + TT) was 1.8 mm Hg (P=0.04) higher than in those with GG genotype. That similar results were obtained from subjects of different races suggests that the Lys198Asn polymorphism of ET-1 is involved in determination of BP levels in obese subjects.