gebhart/patrepeval huggingface dataset:
Effect of probiotics on growth and survival of post larvae of giant freshwater prawn, Macrobrachium rosenbergii (de man) (2012)

The trend of using probiotics in aquaculture is increasing due to research results indicating their ability to increase production and prevent disease in farm animals. The development of suitable probiotics for bio-control in aquaculture would result in less reliance on chemicals and antibiotics and result in a better environment. The production of high quality larvae in scampi is very difficult, since the disease out breaks are the major constraints in scampi hatcheries. Controlling diseases through antibiotics has been widely criticized for their negative impacts, so alternate methods needed to be developed to produce high quality scampi larvae. Application of water probiotics, soil probiotics and reduction of salinity are the methods gaining importance in controlling pathogen in scampi larvae. The larval rearing tanks are divided into four chambers for our convenience. The probiotics treated tanks are considered as experimental and without probiotics treated are considered as control. The water probiotics namely C.P (Super Biotic) and Biodream (Probiotic contains Bacillus sp . and Streptococcus sp. ) was added in the experimental tanks alone @ 5ppm each @ 5- 10 ppm from Zoea stage-II onwards and probiotics Zymatin @ 5ppm was added after the appearance of post larval stage in experimental tanks. In addition to probiotics 0.05 ppm of Treflan was also added both experimental and control tanks to prevent the fungal disease. Water temperature, pH, dissolved oxygen, NH 3 and H 2 S were found better in trials with probiotics. In this experiment the survival rate of the nauplii of both control and experimental tanks were more or less same. The survival rate of Zoea reared in the experimental tanks was higher (84%) than that of control tanks (62%). The survival rate of all the post larval stages (PL 1- PL-10) was higher in experimental tanks than that of control tanks. Water quality parameters are also influenced by the addition of probiotics, in this experiment the dissolved oxygen was higher in experimental (6.10 ppm) and lower in control tank (5.50 ppm). The alkalinity (120 ppm) in both control and experimental tank is more or less similar. The Ammonia was higher in control tanks (0.15 ppm) compared experimental tanks (0.12 ppm). // //
Current treatment and immunotherapy of Hodgkin's lymphoma. (2005)

The treatment of Hodgkin's lymphoma has changed significantly over the last decades, rendering this entity one of the most curable human cancers. To date, about 80% of patients achieve long-term disease-free survival. Current strategies in first-line treatment aim at further improving outcome and thereby preventing therapy-induced complications, such as infertility, cardiopulmonary toxicity, and secondary malignancies. Ongoing trials for patients in early stages are investigating lower radiation doses and smaller radiation fields and possible reductions in the doses or number of cycles of chemotherapy given. For patients in advanced stages, new drug combinations with higher dose density and intensity have been developed, and are currently being evaluated in clinical trials. Approaches for relapsed Hodgkin's lymphoma comprise salvage radiotherapy, salvage chemotherapy and high-dose chemotherapy followed by autologous stem cell transplantation. In recent years, the introduction of effective salvage high-dose therapy and a better understanding of prognostic factors have remarkably improved the management of relapsed Hodgkin's lymphoma. For multiple pretreated patients antibody-based agents that showed promising results in experimental models are being investigated in clinical trials. Radioimmunoconjugates and monoclonal antibodies have demonstrated some clinical efficacy. Here, we review new aspects in the treatment of primary and relapsed Hodgkin's lymphoma as well as recent immunotherapeutic approaches.
Synthesis of highly stable pure-silica thin-walled hexagonally ordered mesoporous material (2009)

Hexagonally ordered mesoporous silica with a very narrow mesopore size distribution and exceptionally high stability paired with unusually thin pore walls was prepared using piperidine and cetyltrimethylammonium bromide.
Measuring n-photon Indistinguishability (2022)

Abstract: We propose a scalable measurement of the indistinguishability of a n-photon state harnessing a multi-port interferometer. We demonstrate this method using four photons from a quantum dot single-photon source with an integrated cyclic interferometer.
Minimal solutions for the multi-camera pose estimation problem (2015)

In this paper, we propose a novel formulation to solve the pose estimation problem of a calibrated multi-camera system. The non-central rays that pass through the 3D world points and multi-camera system are elegantly represented as Plücker lines. This allows us to solve for the depth of the points along the Plücker lines with a minimal set of three-point correspondences. We show that the minimal solution for the depth of the points along the Plücker lines is an eight-degree polynomial that gives up to eight real solutions. The coordinates of the 3D world points in the multi-camera frame are computed from the known depths. Consequently, the pose of the multi-camera system, i.e. the rigid transformation between the world and multi-camera frames can be obtained from absolute orientation. We also derive a closed-form minimal solution for the absolute orientation. This removes the need for the computationally expensive singular value decompositions during the evaluations of the possible solutions for the depths. We identify the correct solution and do robust estimation with RANSAC. Finally, the solution is further refined by including all the inlier correspondences in a nonlinear refinement step. We verify our approach by showing comparisons with other existing approaches and results from large-scale real-world datasets.
Successful Treatment of Vulvar Lichen Sclerosus With Topical Tacrolimus (2003)

A 19-year-old woman was admitted to our department with a history of itching and pain of the vulvar region. During a period of 6 months, her clinical symptoms had significantly deteriorated resulting in painful urination and defecation in addition to dyspareunia. Clinical examination showed well-demarcated, smooth, whitish shiny plaques that affected the labia minora, introitus vaginae, and the clitoral hood. Lesions extended to the posterior fourchette, perineum, and anus. The mucosa appeared thin and fragile with a cellophane paper–like texture. The clinical picture suggested a diagnosis of lichen sclerosus.
Patient-level improvements in pain and activities of daily living after total knee arthroplasty (2013)

Our study provides comprehensive data for patient-level improvements in pain and key ADLs. These data can be used to inform patients pre-operatively of expected outcomes, based on pre-operative status, which may further help patients set realistic goals for improvements after TKA.
SUN-LB002 CYP11A1 Inhibition as a Therapeutic Approach for the Treatment of Castration Resistant Prostate Cancer (2019)

Background: Prostate cancer is a major global challenge due to the increasing number of aging population and frequency of diagnosis. During the past decade new treatments have been targeted to the androgen signaling axis either by inhibiting the binding of androgens to androgen receptor (AR) and AR nuclear translocation, or by inhibiting androgen production via CYP17A1 enzyme. Despite the significant progress on the research and new therapies, CRPC is still incurable and there is urgent need for better, more effective treatments. ODM-208 is an oral, non-steroidal and selective inhibitor of CYP11A1 enzyme, suppressing the synthesis of all steroid hormones that could be potential agonistic AR ligands. Methods: The inhibition of CYP11A1 was measured in vitro by the formation of radiolabelled isocapronic acid in a human adrenal cortex cell line (H295R). The tumor growth inhibition of ODM-208 was studied in VCaP castration-resistant prostate cancer (CRPC) xenograft model. At the end of the xenograft study, plasma ACTH and LH, and key steroid hormone concentrations were analysed from plasma and target tissues. In addition, full length AR (AR-FL) and AR-V7 were analysed from the tumors by western blot and key enzymes of androgen biosynthesis, CYP17A1, AKR1C3, SRD5A1 were quantified by qPCR. In dogs an ACTH stimulation test was done. Results: ODM-208 potently inhibits CYP11A1 enzyme in vitro. In addition, in vivo in the VCaP CRPC xenograft model ODM-208 significantly inhibited tumor growth. Importantly, the amount of AR-FL and AR-V7 levels remained unchanged in the tumors after ODM-208 treatment. Slight increase of CYP17A1 and SRD5A1 enzyme levels was observed, indicating the activation of steroidogenesis in VCaP tumors in vivo. Treatment had no effect on plasma LH, whereas ACTH was significantly increased demonstrating reduction in glucocorticoid levels by negative feedback. In line with ACTH, all measured steroid hormones were significantly reduced both in plasma and target tissues. In dogs ACTH-stimulated cortisol production was significantly inhibited after single oral dose of ODM-208. Conclusions: ODM-208 shows promising antitumor activity in preclinical CRPC models and has favorable toxicological profile. Thus, ODM-208 might have potential for treating patients with CRPC. Based on the nonclinical results, a phase 1/2 clinical trial has been initiated. Unless otherwise noted, all abstracts presented at ENDO are embargoed until the date and time of presentation. For oral presentations, the abstracts are embargoed until the session begins. Abstracts presented at a news conference are embargoed until the date and time of the news conference. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO.
Selection and characterization of DNA aptamers against VEGF165 with aptamer blotting method and its application (2007)

We have isolated two DNA aptamers against a tumor marker protein, human vascular endothelial growth factor (VEGF165). To select aptamers that have high specificity for VEGF165, we used another protein as a competitor in the SELEX process. In addition, we evaluated the screened library with aptamer blotting. Isolated aptamers bound to VEGF165 with Kd in a few hundred-nanomolar ranges, and did not bind to a competitor. This selection method allowed us to select the specific aptamers against a target protein efficiently. Furthermore, isolated aptamers did not bind to VEGF121. These specific DNA aptamers against VEGF165 would be a useful sensing element for cancer diagnosis.
MIC Interactive Dance System-an emotional interaction system (2002)

We have been researching a method for expressing emotional images by utilizing multimedia like video and sound and so on. Human body motion is one of the important essences in expressing human emotion. We chose dance as a subject of our research, because dance performers perform motion to express the emotion in their mind. Our research results show that the multiple regression method effectively extracts human emotion from simple motion parameters given by image processing. MIDAS (MIC Interactive Dance System) is an application of the emotion extraction method. The extraction method and MIDAS are introduced.
Accurate label-free 3-part leukocyte recognition with single cell lens-free imaging flow cytometry (2018)

Three-part white blood cell differentials which are key to routine blood workups are typically performed in centralized laboratories on conventional hematology analyzers operated by highly trained staff. With the trend of developing miniaturized blood analysis tool for point-of-need in order to accelerate turnaround times and move routine blood testing away from centralized facilities on the rise, our group has developed a highly miniaturized holographic imaging system for generating lens-free images of white blood cells in suspension. Analysis and classification of its output data, constitutes the final crucial step ensuring appropriate accuracy of the system. In this work, we implement reference holographic images of single white blood cells in suspension, in order to establish an accurate ground truth to increase classification accuracy. We also automate the entire workflow for analyzing the output and demonstrate clear improvement in the accuracy of the 3-part classification. High-dimensional optical and morphological features are extracted from reconstructed digital holograms of single cells using the ground-truth images and advanced machine learning algorithms are investigated and implemented to obtain 99% classification accuracy. Representative features of the three white blood cell subtypes are selected and give comparable results, with a focus on rapid cell recognition and decreased computational cost.
ConfChem Conference on A Virtual Colloquium to Sustain and Celebrate IYC 2011 Initiatives in Global Chemical Education—The Continuing Celebration of IYC 2011: What the IUPAC Polymer Division Is Doing To Keep Things Going (2013)

The IUPAC polymer division regards the International Year of Chemistry as a starting point for ongoing engagement with the public to better communicate the important role of polymer chemistry in serving society. Prior to that we had started a polymer division education Web site to distribute the contents of an educational CD focused on polymers. This Web site became our principal tool for IYC activities including a video and essay contest aimed at high school and university students, an international funding call, and a list of polymer division sponsored IYC events and conferences. In addition, it provides links to educational Web sites around the world, videos related to polymer scientists and polymer division award winners, and simple definitions of common polymer terms. This communication discusses the results of a student competition, an international funding call designed by national funding agencies to develop best practices for multinational research programs, and noteworthy aspects of the educational Web site and summarizes one of the invited papers to the ConfChem online conference A Virtual Colloquium to Sustain and Celebrate IYC 2011 Initiatives in Global Chemical Education, held from May 18 to June 29, 2012 and hosted by the ACS DivCHED Committee on Computers in Chemical Education (CCCE) and the IUPAC Committee on Chemistry Education.
HELP (Hydrogen peroxide electrochemical profiling): A novel biosensor for measuring hydrogen peroxide levels expressed in breath for monitoring airway inflammation using electrochemical methods (2022)

Breathomics is being explored as a non-invasive pathway for disease diagnosis. In this paper we describe the design and fabrication of an electrochemical transduction-based sensing scheme that can be used for the non-invasive diagnosis of respiratory inflammation by monitoring hydrogen peroxide (H2O2) vapors in breath. AuNP-nafion@[BMIM]BF4 modified electrode forms the backbone of the electrochemical sensor platform. This is the first report of an electrochemical sensor platform for assessing airway inflammation by monitoring H2O2 levels in the lower parts-per billion (50 ppb) range. We engineered the RTIL interaction with the target analyte through computational and chemical modeling. The results obtained via computational and electrochemical modeling helped in strengthening our premise and serve as a proof-of-concept for the advancement of a breathomics-aided electrochemical detection approach.
Model-based protocol log generation for testing a telecommunication test harness using CLP (2014)

Within telecommunications development it is vital to have frameworks and systems to replay complicated scenarios on equipment under test, often there are not enough available scenarios. In this paper we study the problem of testing a test harness, which replays scenarios and analyses protocol logs for the Public Warning System service, which is a part of the Long Term Evolution (LTE) 4G standard. Protocol logs are sequences of messages with timestamps; and are generated by different mobile network entities. In our case study we focus on user equipment protocol logs. In order to test the test harness we require that logs have both incorrect and correct behaviour. It is easy to collect logs from real system runs, but these logs do not show much variation in the behaviour of system under test. We present an approach where we use constraint logic programming (CLP) for both modelling and test generation, where each test case is a protocol log. In this case study, we uncovered previously unknown faults in the test harness.
Computational modeling of retinal hypoxia and photoreceptor degeneration in patients with age-related macular degeneration (2019)

Although drusen have long been acknowledged as a primary hallmark of dry age-related macular degeneration (AMD) their role in the disease remains unclear. We hypothesize that drusen accumulation increases the barrier to metabolite transport ultimately resulting in photoreceptor cell death. To investigate this hypothesis, a computational model was developed to evaluate steady-state oxygen distribution in the retina. Optical coherence tomography images from fifteen AMD patients and six control subjects were segmented and translated into 3D in silico representations of retinal morphology. A finite element model was then used to determine the steady-state oxygen distribution throughout the retina for both generic and patient-specific retinal morphology. Oxygen levels were compared to the change in retinal thickness at a later time point to observe possible correlations. The generic finite element model of oxygen concentration in the retina agreed closely with both experimental measurements from literature and clinical observations, including the minimal pathological drusen size identified by AREDS (64 μm). Modeling oxygen distribution in the outer retina of AMD patients showed a substantially stronger correlation between hypoxia and future retinal thinning (Pearson correlation coefficient, r = 0.2162) than between drusen height and retinal thinning (r = 0.0303) indicating the potential value of this physiology-based approach. This study presents proof-of-concept for the potential utility of finite element modeling in evaluating retinal health and also suggests a potential link between transport and AMD pathogenesis. This strategy may prove useful as a prognostic tool for predicting the clinical risk of AMD progression.
A Development of Fast Speed Monte-Carlo Ray Tracing Method and Study of the Characteristics of an Absolute Reflectometer (2014)

We proposed a new algorithm to improve the calculation speed of forward ray tracing method which was quite a problem in conventional Monte Carlo algorithm.To verify the accuracy and the effect of improving calculation speed, we directly compared integrating sphere characteristics with conventional ray tracing algorithm under the same condition which was referred in a reference paper.By applying new algorithm to an absolute reflectometer, we calculated the degree of errors which were caused by baffle and port characteristics to find optimal system design condition.
A Robust Electrochemical Humidity Sensor for the Detection of Relative Humidity Using Room Temperature Ionic Liquid (RTIL) for Integration in Semiconductor IC's (2018)

Humidity sensing is critical in environmental and industrial spaces to monitor air conditions for the wellbeing of the human population and to ensure favorable industrial processes such as storage and performance. In this work, we utilize room temperature ionic liquids (RTILs) as novel sensing elements toward the development of a robust electrochemical humidity sensor for integration in semiconductor technology. For this study, we report and discuss the performances of a non-fluorinated RTIL vis-a-vis a fluorinated RTIL, MMIM[MeSO4] and EMIM[TF2N], on exposure to humidity levels 25–65%RH at low (25–45°C) and elevated temperatures (65°C). The electrochemical responses of the RTILs to humidity and temperature are recorded via electrochemical impedance spectroscopy to measure the capacitance changes occurring within the electrochemical double layer. Both RTILs show similar responses to humidity levels and temperatures. This work is the first demonstration of the implementation of RTILs on micro electronic devices toward achieving rapid and sensitive humidity sensing.
Efficient Targeted Mutagenesis Mediated by CRISPR-Cas12a Ribonucleoprotein Complexes in Maize (2021)

Recent advances in the development of CRISPR-Cas genome editing technologies have made it possible to perform targeted mutagenesis and precise gene replacement in crop plants. CRISPR-Cas9 and CRISPR-Cas12a are two main types of widely used genome editing systems. However, when CRISPR-Cas12a editing machinery is expressed from a transgene, some chromosomal targets encountered low editing frequency in important crops like maize and soybean. Here, we report efficient methods to directly generate genome edited lines by delivering Cas12a-gRNA ribonucleoprotein complex (RNP) to immature maize embryos through particle bombardment in an elite maize variety. Genome edited lines were obtained at ~7% frequency without any selection during regeneration <i>via</i> biolistic delivery of Cas12a RNP into immature embryos. Strikingly, the gene editing rate was increased to 60% on average and up to 100% in some experiments when the Cas12a RNP was co-delivered with a PMI selectable marker gene cassette and the induced callus cultures were selected with mannose. We also show that use of higher activity Cas12a mutants resulted in improved editing efficiency in more recalcitrant target sequence. The advances described here provide useful tools for genetic improvement of maize.
Effects of Firing Temperature and Film Thickness on the Critical Properties of YBCO Film by the '211 Process' (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Supplementary Figure S2 from <i>KIT</i> and <i>PDGFRA</i> Mutations and Survival of Gastrointestinal Stromal Tumor Patients Treated with Adjuvant Imatinib in a Randomized Trial (2023)

&lt;p&gt;Kaplan-Meier estimates of recurrence-free survival of patients with KIT exon 11 substitution mutation (A) and patients with KIT exon 9 mutation (B). The 5-year and 10-year survival rates are shown. Censored patients are indicated with a bar&lt;/p&gt;
Patient-Reported Status and Heart Failure Outcomes in Asia by Sex, Ethnicity, and Socioeconomic Status (2023)

Serial measures of patient-reported symptoms and HRQoL are significant and consistent predictors of outcomes among different groups with HF and provide the potential for a patient-centered and pragmatic approach to risk stratification.
Frequency Sensitivity and Electromechanical Propagation Simulation Study in Large Power Systems (2007)

A global view of power system's frequency behavior opens up a new window for analyzing system's dynamics. With the aid of global positioning system, measurements from different locations would have synchronous time; therefore a system-wide observation and analysis would be possible. As part of the US-wide power frequency monitoring network project this paper focus on simulation study results of power frequency dynamics of the Eastern U.S. system. The study assesses the frequency measurement accuracy needed to observe frequency dynamics from events such as remote generation drops. Electromechanical-wave propagation phenomena during system disturbances have been observed. The speeds of electromechanical-wave propagation in different areas of the U.S. systems were estimated and their characteristics were discussed.