gebhart/patrepeval huggingface dataset:
Performance Investigation of Two-, Three- and Four-Phase Bearingless Slice Motor Configurations (2007)

The fact that bearingless slice motors (BSM) are widely used in pump systems in the semiconductor industry and for medical applications has caused the attention of other industries for this emerging technology. Here, costs, power consumption and pump volume play an important role. Since the mechanical setup of the motor has a strong impact on these issues five different motor and converter setups are comparatively evaluated and discussed in this paper. The comparison will be carried out for two-, three- and four-phase BSM concepts based on performance indices such as power losses, power electronics requirements and cost-related realisation issues.
Synthesis Of Self-resetting Stage Logic Pipelines (2006)

ii As designers began to pack multi-million transistors onto a single chip, their reliance on a global clocking signal to orchestrate the operations of the chip has started to face almost insurmountable difficulties. As a result, designers started to explore clockless circuits to avoid the global clocking problem. Recently, self-resetting circuits implemented in dynamic logic families have been proposed as viable clockless alternatives. While these circuits can produce excellent performances, they display serious limitations in terms of area cost and power consumption. A middle-of-the-road alternative, which can provide a good performance and avoid the limitations seen in dynamic self-resetting circuits, would be to implement self-resetting behavior in static circuits. This alternative has been introduced recently as Self-Resetting Stage Logic and used to propose three types of clockless pipelines. Experimental studies show that these pipelines have the potential to produce high throughputs with a minimum area overhead if a suitable synthesis methodology is available. This thesis proposes a novel synthesis methodology to design and verify clockless pipelines
A Mixed Ligand Approach for the Asymmetric Hydrogenation of 2‐Substituted Pyridinium Salts (2016)

Abstract Herein we describe a new methodology for the asymmetric hydrogenation (AH) of 2‐substituted pyridinium salts. An iridium catalyst based on a mixture of a chiral monodentate phosphoramidite and an achiral phosphine was shown to hydrogenate N ‐benzyl‐2‐arylpyiridinium bromides to the corresponding N ‐benzyl‐2‐arylpiperidines with full conversion and good enantioselectivity. The mechanism of the reaction under optimized conditions was investigated via kinetic measurements and isotopic labeling experiments. Our study suggests that the hydrogenation starts with a 1,4‐hydride addition and that the enantiodiscriminating step involves the reduction of an iminium intermediate. magnified image
On the Design and Prototype Implementation of a Multimodal Situation Aware System (2009)

In this paper we describe the design concepts and prototype implementation of a situation aware ubiquitous computing system using multiple modalities such as National Marine Electronics Association (NMEA) data from Global Positioning System (GPS) receivers, text, speech, environmental audio, and handwriting inputs. While most mobile and communication devices know where and who they are, by accessing context information primarily in the form of location, time stamps, and user identity, the concept of sharing of this information in a reliable and intelligent fashion is crucial in many scenarios. A framework which takes the concept of context aware computing to the level of situation aware computing by intelligent information exchange between context aware devices is designed and implemented in this work. Four sensual modes of contextual information like text, speech, environmental audio, and handwriting are augmented to conventional contextual information sources like location from GPS, user identity based on IP addresses (IPA), and time stamps. Each device derives its context not necessarily using the same criteria or parameters but by employing selective fusion and fission of multiple modalities. The processing of each individual modality takes place at the client device followed by the summarization of context as a text file. Exchange of dynamic context information between devices is enabled in real time to create multimodal situation aware devices. A central repository of all user context profiles is also created to enable self-learning devices in the future. Based on the results of simulated situations and real field deployments it is shown that the use of multiple modalities like speech, environmental audio, and handwriting inputs along with conventional modalities can create devices with enhanced situational awareness.
Identification and Partial Characterization of an Unusual Distribution of the Photosensitizer meta-Tetrahydroxyphenyl Chlorin (Temoporfin) in Human Plasma (1999)

Abstract— Temoporfin (m-THPC) is an extremely powerful photosensitizing drug, more than 100-fold more photocytotoxic than Photofrin and many other drugs. The reasons for this are not yet known but are likely to be associated with the mechanism of uptake of the drug and its intratumoral and intracellular localization. Uptake itself is likely to be dependent upon the plasma binding of the drug following administration. In the current work, we have shown that the addition of m-THPC to human plasma in vitro at clinically relevant doses of sensitizer and administration solvent (diluant) gives rise to a protein-binding pattern quite different to that of Photofrin and other hydrophobic drugs as judged by density-gradient ultra centrifugation. Analysis of the binding immediately after addition to human plasma has shown that lipoprotein binding accounts for only a minor proportion of the sensitizer, which is mainly associated with a high-density protein fraction that is not coincident with serum albumin. The m-THPC protein complex does not fluoresce significantly even on dilution. This binding pattern is highly dependent on administration conditions and storage. Over a period of 6–8 h at 37°C the m-THPC that is associated with this unidentified fraction redistributes to the plasma lipoproteins. Plasma collected from rats after intravenous administration of m-THPC also contains this low fluorescent complex, showing that this phenomenon is not limited to human plasma and also occurs in vivo. It is postulated that the m-THPC bound to the unknown protein fraction is highly aggregated and that it is likely to be taken up into tissues in this form. This unusual uptake may possibly be associated with the very high activity of m-THPC and also to the recent finding of a second peak in the plasma pharmacokinetics of the drug.
Monitoring of hemostatic status in four patients being treated with recombinant factor VIIa. (2004)

Recombinant Factor VIIa (rVIIa) is a potent hemostatic agent for the management of refractory bleeding in patients with Factor VII deficiency or Factor VIII inhibitors. While the current recommended dose is usually effective, the most appropriate dose remains a subject of debate. Since factor VII levels and shortening of the pro-thrombin time do not appear to correlate with response, an appropriate laboratory marker of clinical response has not been identified. In this article we report changes noted in thrombin generation, platelet function and clot structure in blood from patients treated with rVIIa. Thrombin generation was assessed via a thrombin generation time (TGT) assay using a Hemodyne HAS instrument. Changes in clot structure were assessed as changes in clot elastic modulus in the HAS, changes in maximum amplitude in the TEG and changes in maximum clot firmness in the ROTEG. The cases presented confirmed improvement in thrombin generation with administration of rVIIa. The cases also illustrate that: a) in the factor VII deficient patient, 25% of the 90 microg/kg dose is sufficient to totally correct the defect, b) patients with high level factor VIII inhibitors may require significantly more than the recommended dose of 90 microg/kg, c) thrombin generation may not be completely corrected despite dramatic shortening of the prothrombin time, and d) increasing rVIIa doses does not by itself ensure improved thrombin generation.
480. In Vivo Gene Targeting for HIV Immunoprophylaxis using Promoterless AAV Without Nucleases (2015)

Expression of broadly neutralizing antibodies (bNAbs) from AAV can provide protection against infections by different pathogens, including: HIV, Influenza and Plasmodium falciparum. Wide use of such vectored immunoprophylaxis will depend on the safety profile and on the duration of the immune effect. Alarmingly, AAV injection in neonatal mice has been associated with subsequent development of hepatocellular carcinoma (HCC) and adenoma (HCA) in a manner that is strictly dependent on the vector borne promoter. In addition, when the antibody is expressed from an AAV episome, the duration of prophylaxis might be limited by vector dilution when transfected cells divide. Alternatively, nucleases can be used to promote stable transgene expression, but these may be associated with adverse effects such as immunogenicity and genotoxicity. Recently, we have shown that AAV could be used for promoterless gene targeting without nucleases for stable expression of coagulation factor IX in the context of hemophilia treatment (Barzel et al. Nature 2015). Here, we apply a similar methodology to target the integration of a gene coding for a bNAb against HIV to be driven upon integration by the strong Albumin promoter in the liver. Tail vein injection of our vector, coding for the VRC01 anti HIV bNAb, at 1E12 vector genomes per mouse into adult B6 mice leads to high (250 ng/ml) and stable levels of the bNAb in the plasma of the mice. We further show that the bNAb from the plasma is highly effective in binding the HIV envelope glycoprotein: gp120. In order to assess the potential of our approach in HIV prophylaxis and cure we have transplanted neonatal NOD/SCID/gc null (NSG) mice with human CD34+ HSC cells (1E6 cells/pup). Mice that are effectively reconstituted with human immune cells will be challenged with HIV (100-200ng p24 units) either prior to injection with our bNAb coding AAV (to assess therapeutic potential) or following such an injection (to assess prophylactic potential). For HIV and other infections where conventional vaccination is challenging, stable immunoprophylaxis using a promoterless AAV coding for a bNAb may constitute a safe and efficient alternative.
A high-Q octave-tunable all-silicon cavity filter using magnetostatic actuation (2016)

This paper presents, for the first time, a magnetostatically tuned capacitive-post loaded evanescent-mode cavity filter for C..X band reconfigurable RF front-ends. Unlike electrostatically-actuated MEMS tuners that exhibit unidirectional actuation, the presented technique allows for bidirectional tuner deflections to be achieved. The measured device is a two-pole Butterworth bandpass filter that demonstrates an analog tuning from 6.8-13.2 GHz (1:1.94 tuning ratio) while maintaining a near-constant 1% fractional bandwidth. The filter insertion loss varies from 4.2-1.8 dB (including connector losses) from the lowest to highest frequency, which corresponds to an unloaded quality factor of 300-700. The filter has an overall size of ≤ 1 in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> including fixture, and consumes ≤ 0.5 W DC-power per-pole in the bi-directional magnetostatic actuation to achieve maximum tuning. Such tuning methods are potentially useful in applications where power consumption is not a major constraint (e.g. base stations) and/or where bidirectional tuner actuation is desired.
Improving AoI via Learning-based Distributed MAC in Wireless Networks (2022)

In this work, we consider a remote monitoring scenario in which multiple sensors share a wireless channel to deliver their status updates to a process monitor via an access point (AP). Moreover, we consider that the sensors randomly arrive and depart from the network as they become active and inactive. The goal of the sensors is to devise a medium access strategy to collectively minimize the long-term mean network \ac{AoI} of their respective processes at the remote monitor. For this purpose, we propose specific modifications to ALOHA-QT algorithm, a distributed medium access algorithm that employs a policy tree (PT) and reinforcement learning (RL) to achieve high throughput. We provide the upper bound on the mean network Age of Information (AoI) for the proposed algorithm along with pointers for selecting its key parameter. The results reveal that the proposed algorithm reduces mean network \ac{AoI} by more than 50 percent for state of the art stationary randomized policies while successfully adjusting to a changing number of active users in the network. The algorithm needs less memory and computation than ALOHA-QT while performing better in terms of AoI.
Synthesis of P-Chiral Dihydrobenzooxaphosphole Core for BI Ligands in Asymmetric Transformations (2017)

An efficient and practical synthesis of enantiomerically pure P-chiral dihydrobenzooxaphosphole (BOP) core 1 is developed that is amenable to large scale preparation of the related ligand series. The unique epimerization of the P-chiral center of the undesired (R,R)-diastereomeric phosphine oxide 19 through chlorination followed by crystallization makes this chemical resolution method achieve 65% yield of desired (R,S)-diastereomer 12.
Síntese e caracterização de copolímeros de propeno com 1-hexeno e 1,5-hexadieno (2012)

Copolímeros de propeno com 1-hexeno e 1,5-hexadieno, contendo diferentes teores de comonômeros, foram obtidos utilizando técnicas de polimerização em lama e em massa com catalisadores Ziegler-Natta heterogêneos de alta atividade. Foram avaliadas densidade, propriedades térmicas e mecânicas finais e estrutura do polímero. Os estudos mostraram que a densidade dos polímeros, temperaturas de transição (fusão e cristalização), módulo de rigidez, massa molar média e a cristalinidade diminuem com a incorporação do comonômero, uma vez que as cadeias laterais reduzem a organização da estrutura do copolímero. Os efeitos de densidade são mais apreciáveis no material que contém 1,5-hexadieno, enquanto que a redução na solubilidade em xileno (XS) e os efeitos térmicos são mais evidentes nas amostras com 1-hexeno. Os resultados de ressonância nuclear magnética demonstram que a incorporação do 1,5-hexadieno leva à formação de estruturas cíclicas na cadeia polimérica e que o aumento dos teores de dieno levam à reticulação das cadeias, resultando na produção de material insolúvel nos solventes orgânicos usuais.
Nitric oxide mediated erectile activity is a testosterone dependent event: a rat erection model. (1995)

Classically, androgens were thought to be linked to sexual activity in man through their action on increased libido. Recently, the sex hormone dependent nature of nitric oxide synthase (NOS), the enzyme system producing the neurotransmitter of erection (nitric oxide) has been reported. Our study evaluated how changes in testosterone levels alter erectile function. In forty-seven rats the erectile response to cavernous nerve electrostimulation was recorded 1, 5, 10, 20 and 30 d post-bilateral orchiectomy, and compared to controls. Penile tissue was subsequently stained for the presence of NOS, using an NADPH diaphorase technique. Forty eight rats were used in part two. After orchiectomy exogenous testosterone was administered and the erectile function as well as density of NOS positive nerve fibers was assessed. All castrated animals showed a rapid decrease in serum free testosterone levels within 24 h. In contrast, a gradual decrease in intracavernous pressure was recorded with cavernous nerve stimulation, proportional to the time post orchiectomy. NADPH diaphorase staining showed a decreased density of nonadrenergic noncholinergic (NANC) nerve fibers innervating the cavernosal tissue proportional to the time post orchiectomy. With reconstitution of the androgen mileu the erectile response returned to near normal values and recovery of NADPH-positive nerve fibers was observed. Based on presented data we conclude that testosterone or a metabolite plays a direct role in erection acting through an effect on nitric oxide synthase within the corpora cavernosa.
Table S2 from Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer (2023)

&lt;p&gt;Table S2&lt;/p&gt;
Empirical study of neural network language models for Arabic speech recognition (2007)

In this paper we investigate the use of neural network language models for Arabic speech recognition. By using a distributed representation of words, the neural network model allows for more robust generalization and is better able to fight the data sparseness problem. We investigate different configurations of the neural probabilistic model, experimenting with such parameters as N-gram order, output vocabulary, normalization method, and model size and parameters. Experiments were carried out on Arabic broadcast news and broadcast conversations data and the optimized neural network language models showed significant improvements over the baseline N-gram model.
CHECK'UP: A prospective cohort study to identify predictive factors of response and mechanisms of resistance to PD-1 and PD-L1 antagonists (2018)

Background: Immune checkpoint blockade represents a major breakthrough in cancer therapy with recent approvals of PD-1 or PD-L1 antagonists in a range of indications. Phase 3 studies have demonstrated response rates varying from 13% (head and neck squamous cell carcinoma [HNSCC]) to 40% (melanoma) in sensitive diseases, and impressively durable responses in individual patients. The overall rate of response remains relatively low however. Even in immune-sensitive diseases such as melanoma the majority of tumours do not respond to immunotherapy alone and most tumours will eventually develop resistance to the treatment. Furthermore, although PD-1/PD-L1 antagonists are generally well tolerated, a small but significant number of patients experience severe immune-related toxicity, the risk factors of which are poorly understood. Identifying which patients will most benefit from PD-1/PD-L1 antagonist therapy and the mechanisms of resistance are of critical importance for clinicians. The CHECK’UP trial aims to address this question by studying approved PD-1/PD-L1 antagonist treatment across three cancer indications: melanoma, non-small cell lung cancer (NSCLC) and HNSCC. Trial design: This prospective, multicentre cohort trial will study 670 patients in 3 parallel groups set to receive one of the single agent PD-1 or PD-L1 antagonists authorised for use in France as standard care for melanoma, NSCLC or HNSCC. Clinical and biological sample data (tumour, blood, microbiome) collected at study entry and throughout the treatment period will be analysed to identify potential response biomarkers. Patients will be followed for 5 years. A penalized logistic regression model will be used to identify associations between different parameters and response to treatment in a training cohort, made up of the first patients included, and to develop a predictive response signature for each indication. The performance of this signature will then be tested in an independent validation cohort comprised of the remaining patients. Mechanisms of primary and acquired resistance, occurrence of long-term treatment related toxicity and a cost/benefit assessment of treatment in a real-life setting will also be explored. Legal entity responsible for the study: UNICANCER. Funding: Fondation ARC pour la recherche sur le cancer. Disclosure: All authors have declared no conflicts of interest.
Fake News Detection with Generated Comments for News Articles (2020)

Recently, fake news is shared via social networks and makes wrong rumors more diffusible. This problem is serious because the wrong rumor sometimes make social damage by deceived people. Fact-checking is a solution to measure the credibility of news articles. However the process usually takes a long time and it is hard to make it before their diffusion. Automatic detection of fake news is a popular researching topic. It is confirmed that considering not only articles but also social contexts(i.e. likes, retweets, replies, comments) supports to spot fake news correctly. However, the social contexts are naturally unavailable when an article comes out, making early fake news detection by means of the social context useless. We propose a fake news detector with the ability to generate fake social contexts, aiming to detect fake news in the early stage of its diffusion where few social contexts are available. The fake context generation is based on a fake news generator model. This model is trained to generate comments using a dataset which consists of news articles and their social contexts. In addition, we also trained a classify model. This used news articles, real-posted comments, and generated comments. To measure our detector's effectiveness, we examined the performance of the generated comments for articles with real comments and generated ones by the classifying model. As a result, we conclude that considering a generated comment help detect more fake news than considering real comments only. It suggests that our proposed detector will be effective to spot fake news on social networks.
RADIOFREQUENCY HEATING OF PAINFUL ANNULAR DISRUPTIONS WITH THE DISCTRODE: 18-MONTH OUTCOMES (2004)

Introduction: Although several studies have reported on outcomes following heating of annular tears with a thermo-resistive catheter (SpineCATH), little data is available on the efficacy of thermal treatment with a flexible radiofrequency electrode (discTRODE). The aim of this prospective case-control study was to determine the efficacy of radiofrequency heating of painful annular tears in the lumbar spine. Methods: After at least six months of conservative treatment, 46 patients were studied for the presence of single level painful annular tears with MRI and provocative discography. Thirty-one patients underwent heating of their annular tears with a flexible radiofrequency electrode placed across the posterior annulus. The remaining fifteen patients continued with conservative management and acted as a control group. At present, 22 patients have been studied at 18 months follow-up and the remainder including the control group for a minimum of one year. The Visual Analogue Scale (VAS), the Oswestry Disability Index (ODI) and the Medication Quantification Score (MQS) were obtained before and at three monthly intervals after treatment. Results: VAS decreased significantly after the radio-frequency treatment, and this decrease persisted at 18 months follow-up. The VAS did not change over 18 months in untreated controls. The decrease in VAS was significantly greater in the treated patients than the controls. The ODI also decreased in treated patients but did not change in controls. The MQS did not change in either group over the 18-month follow-up period. Discussion: Radiofrequency heating of annular tears can lead to an improvement in the pain and disability of internal disc disruption. The improvement gained by this treatment method is significantly better than conservative management.
Optical memory systems for 3-D computing architectures (2002)

Summary form only given. Due to their dimensional compatibility 3-D memories and 3-D packaged electronic processing systems may be naturally well suited to each others needs. For example, 3-D electronic processing systems can provide high speed data compression, decompression, error correction, cache memory and various database functions needed for 3-D optical storage systems. On the other hand, 3-D optical storage systems may well provide the compact high bandwidth secondary storage system solutions that 3-D packaged image processing systems may need. This talk will explore these possibilities and will attempt to outline means by which these devices can be interfaced advantageously.