gebhart/patrepeval huggingface dataset:
Estimation of Doppler spread and signal strength in mobile communications with applications to handoff and adaptive transmission (2001)

Abstract Estimation of signal strength, a measure of channel quality, and Doppler spread which is proportional to the mobile speed, are important for handoff algorithms and optimal tuning of system parameters to changing channel conditions in adaptive transmission systems. This paper provides a survey of existing techniques for estimating the statistical parameters of the mobile channel. We discuss the current state of the art in estimation of the received signal strength, mobile velocity, and other related statistical channel parameters, illustrate their performance, and compare existing techniques. The sensitivity of these schemes to modeling error owing to the presence of line of sight, directional reception, and noise is characterized analytically and illustrated by simulations. Copyright © 2001 John Wiley &amp; Sons, Ltd.
Fluid–structure simulation of a viscoelastic hydrofoil subjected to quasi-steady flow (2010)

Fluid-structure interaction simulations are performed for a flexible hydrofoil subjected to quasi-steady flow conditions. The hydrofoil is fabricated from a polymeric material that exhibits viscoelastic effects, causing the hydrofoil to change shape while subjected to the fluid loads. The time-dependent deformations and loads will be compared in the future to empirical results from upcoming water tunnel tests. The fluid-structure interaction simulations are performed using a tightly coupled partitioned approach, with OpenFOAM as the flow solver and a finite element solver for the structural response. The codes are coupled using a fixed-point iteration with relaxation. The flow is modeled as laminar and quasisteady. Simulations indicate the hydrofoil angle of attack (AOA) changes from zero to a negative value as the material relaxes. The approach used here is being developed for application to a blood pump that has a performance closely tied to blade deformation through the impeller tip clearance.
A robust coregistration method for in vivo studies using a first generation simultaneous PET/MR scanner (2010)

The authors present an implementation of an efficient and robust coregistration scheme for multimodal noninvasive imaging using PET and MR. This setup allows time-sensitive, multimodal studies of physiology to be conducted in an efficient manner.
Specific heat of geometrically frustrated and multiferroicRMn1−xGaxO3(R=Ho,Y) (2006)

Specific heat measurements on single crystals of $R{\mathrm{Mn}}_{1\ensuremath{-}x}{\mathrm{Ga}}_{x}{\mathrm{O}}_{3}$ $(R=\mathrm{Ho},\mathrm{Y})$ have revealed that Ga doping raises the Mn-spin reorientation temperature ${T}_{\mathrm{SR}}$ while lowering the antiferromagnetic ordering temperature, ${T}_{\mathrm{N}}$, of the Mn spins and the Ho magnetic ordering temperature ${T}_{2}$. The variations of the calculated magnetic entropy with Ga doping show the existence of spin fluctuations above ${T}_{\mathrm{N}}$ in the geometrically frustrated Mn-spin system and a coupling between the ${\mathrm{Mn}}^{3+}$-ion and ${\mathrm{Ho}}^{3+}$-ion spins both at ${T}_{\mathrm{SR}}$ and ${T}_{2}$. The data also support Schottky anomalies in the specific heat of $\mathrm{Ho}{\mathrm{Mn}}_{1\ensuremath{-}x}{\mathrm{Ga}}_{x}{\mathrm{O}}_{3}$, which is dominated by crystalline electric fields but also affected by ${\mathrm{Mn}}^{3+}$-ion spin orderings. The large electronic contribution to specific heat of $\mathrm{Ho}\mathrm{Mn}{\mathrm{O}}_{3}$, $\ensuremath{\gamma}$, is suggested to be due to ${\mathrm{Ho}}^{3+}$ spin disorder.
Paranoid Secondary: Waterfilling in a Cognitive Interference Channel with Partial Information (2011)

We study a two-user cognitive channel, where the primary flow is sporadic, cannot be re-designed and operating below its link capacity. To study the impact of primary traffic uncertainty, we propose a block activity model that captures the random on-off periods of primary's transmissions. Each block in the model can be split into parallel Gaussian-mixture channels, such that each channel resembles a multiple user channel (MAC) from the point of view of the secondary user. The secondary senses the current state of the primary at the start of each block. We show that the optimal power transmitted depends on the sensed state and the optimal power profile is paranoid, i.e. either growing or decaying in power as a function of time. We show that such a scheme achieves capacity when there is no noise in the sensing. The optimal transmission for the secondary performs rate splitting and follows a layered water-filling power allocation for each parallel channel to achieve capacity. The secondary rate approaches a genie-aided scheme for large block-lengths. Additionally, if the fraction of time primary uses the channel tends to one, the paranoid scheme and the genie-aided upper bound get arbitrarily close to a no-sensing scheme.
Generic immunoassay of corticosteroids with minimum pre-treatment of urine samples (1994)

A generic, rapid and sensitive enzyme linked immunosorbent assay (ELISA) test has been developed which allows large-scale simultaneous testing of synthetic corticosteroids viz., flumethasone, dexamethasone and betamethasone. This assay can be directly applied to diluted urine samples (1 + 9) without hydrolysis of glucuronide or sulfate conjugates or any other treatment of samples. The polyclonal antibody was obtained by immunizing sheep with a flumethasone derivative linked to human serum albumin. This polyclonal antibody displayed high-reactivity with several synthetic corticosteroids whilst endogenous corticosteroids such as cortisol gave very low cross-reactivity (< 0.5%). Sensitivities obtained in this assay were 2.5, 3.1 and 12.5 ng ml-1 for flumethasone, dexamethasone and betamethasone, respectively. The ability of this assay to detect several synthetic corticosteroids was demonstrated by testing urine samples from horses to which the drugs had been administered.
Abstract LB-C24: Resistance to ALK inhibition is associated with enhanced BRD4 dependence in ALK-mutated MYCN-amplified neuroblastoma (2015)

Abstract Despite substantial therapeutic advances, the long-term survival rate of patients with high-risk neuroblastoma (NB), a tumor of the peripheral sympathetic nervous system is still dismal. Activating mutations in the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase represent promising therapeutic targets in this disease and have prompted clinical trials of ALK inhibitors. But as with all molecularly targeted therapies, resistance is inevitable and will limit the ultimate utility of this therapeutic strategy. To elucidate the mechanisms of resistance to ALK inhibitors, we have generated isogenic NB cells, expressing the tumorigenic ALKF1174L mutation and amplified MYCN, with acquired resistance to the ALK inhibitor TAE684, through continuous exposure of increasing concentrations of the compound over time. We found that resistance was associated with downregulation of ALK activity, thus ruling out secondary mutations as a mechanism of resistance, and interestingly the other major oncogenic driver in neuroblastoma, MYCN, was downregulated as well. A comparative genome-wide expression analysis revealed global transcriptional downregulation in the resistant cells, as compared with their parental sensitive counterparts, in accordance with the aforementioned MYCN downregulation, as MYCN is known to act as a transcriptional amplifier in MYCN-amplified NB cells. Additionally, these resistant cells exhibited a 10-fold increased sensitivity to the BRD4 inhibitor JQ1, compared to sensitive cells, and MYCN as well as global gene expression were rescued after treatment. These results strongly suggest that resistance to ALK inhibition in ALKF1174L MYCN-amplified NB cells leads to a MYCN-independent enhanced BRD4 dependence, therefore providing a rationale for the use of BET inhibitors to overcome such resistance. Studies are currently underway to characterize the unique epigenetic landscape driving the resistant cells' survival and therefore identify novel targets that could be taken advantage of in future therapeutic strategies. Citation Format: David Debruyne, Bandana Sharma, Nathanael Gray, Rani George. Resistance to ALK inhibition is associated with enhanced BRD4 dependence in ALK-mutated MYCN-amplified neuroblastoma. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr LB-C24.
Systemic Administration of a Conditionally Replicating Adenovirus, Targeted to Angiogenesis, Reduced Lung Metastases Burden in Cotton Rats (2009)

We have shown here for the first time an antimetastatic effect induced by an angiogenesis-transcriptionally targeted adenovirus following systemic administration. Because adenovirus replication is more efficient in humans than in cotton rats, we assume a significant effect for AdPPE3x-E1 treatment in fighting human solid tumors and metastases.
Risk Factors for Reoperation in Patients Treated Surgically for Intervertebral Disc Herniation (2015)

In patients who underwent surgery for IDH, the overall reoperation rate was 15% at the eight-year follow-up. Patients of older age and patients presenting with asymmetric motor weakness were less likely to undergo a reoperation. Less improvement in patient-reported outcomes was noted in the reoperation group.
Functional Roles of Charged Residues in the Putative Voltage Sensor of the HCN2 Pacemaker Channel (2000)

Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels contribute to pacemaking activity in specialized neurons and cardiac myocytes. HCN channels have a structure similar to voltage-gated K(+) channels but have a much larger putative S4 transmembrane domain and open in response to membrane hyperpolarization instead of depolarization. As an initial attempt to define the structural basis of HCN channel gating, we have characterized the functional roles of the charged residues in the S2, S3, and S4 transmembrane domains. The nine basic residues and a single Ser in S4 were mutated individually to Gln, and the function of mutant channels was analyzed in Xenopus oocytes using two-microelectrode voltage clamp techniques. Surface membrane expression of hemagglutinin-epitope-tagged channel proteins was examined by chemiluminescence. Our results suggest that 1) Lys-291, Arg-294, Arg-297, and Arg-300 contribute to the voltage dependence of gating but not to channel folding or trafficking to the surface membrane; 2) Lys-303 and Ser-306 are essential for gating, but not for channel folding/trafficking; 3) Arg-312 is important for folding but not gating; and 4) Arg-309, Arg-315, and Arg-318 are crucial for normal protein folding/trafficking and may charge-pair with Asp residues located in the S2 and S3 domains.
Pilot-Hopping Sequence Detection Architecture for Grant-Free Random Access using Massive MIMO (2020)

In this work, an implementation of a pilot-hopping sequence detector for massive machine type communication is presented. The architecture is based on solution a non-negative least squares problem. The results show that the architecture supporting 1024 users can perform more than one million detections per second with a power consumption of less than 70 mW when implemented in a 28 nm FD-SOI process.
Prospective Blinded Study of BRAF V600E Mutation Detection in Cell-Free DNA of Patients with Systemic Histiocytic Disorders (2014)

Patients with BRAF(V600E)-mutant histiocytic disorders have remarkable responses to RAF inhibition, but mutation detection in tissue in these disorders is challenging. Here, we identify that analysis of plasma and urinary cfDNA provides a reliable method to detect the BRAF(V600E) mutation and monitor response to therapy in these disorders.
Flow improvement of waxy oils mediated by self-aggregating partially crystallizable diblock copolymers (2002)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Henry S. Ashbaugh, Lewis J. Fetters, Douglas H. Adamson, Robert K. Prud'homme; Flow improvement of waxy oils mediated by self-aggregating partially crystallizable diblock copolymers. Journal of Rheology 1 July 2002; 46 (4): 763–776. https://doi.org/10.1122/1.1485280 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search
SDN-based joint backhaul and access design for efficient network layer operations (2015)

Small cell networks have been broadly regarded as an imperative evolution path for the next-generation cellular networks. Dense small cell deployments will be connected to the core network by heterogeneous backhaul technologies such as fiber, microwave, high frequency wireless solutions, etc., which have their inherent limitations and impose big challenges on the operation of radio access network to meet the increasing rate demands in future networks. To address these challenges, this paper presents an efficient design considered in the iJOIN (Interworking and JOINt Design of an Open Access and Backhaul Network Architecture for Small Cells based on Cloud Networks) project with the objective of jointly optimizing backhaul and radio access network operations through the adoption of SDN (Software Defined Networking). Furthermore, based on this framework, the implementation of several intelligent management functions, including mobility management, network-wide energy optimization and data center placement, is demonstrated.
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling (2022)

Tumors initiate by mutations in cancer cells, and progress through interactions of the cancer cells with non-malignant cells of the tumor microenvironment. Major players in the tumor microenvironment are cancer-associated fibroblasts (CAFs), which support tumor malignancy, and comprise up to 90% of the tumor mass in pancreatic cancer. CAFs are transcriptionally rewired by cancer cells. Whether this rewiring is differentially affected by different mutations in cancer cells is largely unknown. Here we address this question by dissecting the stromal landscape of BRCA-mutated and BRCA Wild-type pancreatic ductal adenocarcinoma. We comprehensively analyze pancreatic cancer samples from 42 patients, revealing different CAF subtype compositions in germline BRCA-mutated vs. BRCA Wild-type tumors. In particular, we detect an increase in a subset of immune-regulatory clusterin-positive CAFs in BRCA-mutated tumors. Using cancer organoids and mouse models we show that this process is mediated through activation of heat-shock factor 1, the transcriptional regulator of clusterin. Our findings unravel a dimension of stromal heterogeneity influenced by germline mutations in cancer cells, with direct implications for clinical research.
Adsorption-Desorption Behavior of Polyvinyl Alcohol on Polystyrene Latex Particles (1984)

The adsorption of fully and partially hydrolyzed (88%) polyvinyl alcohol (PVA) on 190-1100nm monodisperse polystyrene latex particles was investigated. The effect of molecular weight was investigated for 190 nm-size particles using the serum replacement adsorption and desorption methods. The adsorption density at the adsorption-isotherm plateau followed the relationships ΓαM0.5 for the fully hydrolyzed PVA and ΓαM0.72 for the 88%-hydrolyzed PVA. The same dependence was found for the adsorbed layer thickness measured by viscosity and photon correlation spectroscopy. Extension of the adsorption isotherms to higher concentrations gave a second rise in surface concentration, which was attributed to multilayer adsorption and incipient phase separation at the interface. The latex particle size had no effect on the adsorption density; however, the thickness of the adsorbed layer increased with increasing particle size, which was attributed to changes in the configuration of the adsorbed polymer molecules. The electrolyte stability of the bare and PVA-covered particles showed that the bare particles coagulated in the primary minimum and the PVA-covered particles flocculated in the secondary minimum and the larger particles were less stable than the smaller particles.
Identifying tumor vascular genes regulated by Aflibercept (VEGF Trap) (2008)

2497 VEGF blockade has been shown to be effective at inhibiting tumor growth in various preclinical models and in diverse human cancers. Treatment of tumors with VEGF blockers results in a rapid loss of tumor vessels and changes in the phenotype of the tumor vessels, including decrease sprouting and branching. In this study, we sought to characterize in more detail the rapid changes in tumor vessels following VEGF blockade, by identifying vascular genes that are under direct regulation by VEGF in tumors. SCID mice bearing established tumors of different origins (two human renal cell carcinomas (786-0, A498), a human and a rat glioblastoma (U87-MG, C6), and a human colorectal carcinoma (Colo205) were treated with a single subcutaneous dose of aflibercept (VEGF Trap, 25 mg/kg), a potent inhibitor of all isoforms of VEGF-A and placental growth factor (PlGF) that is currently in Phase III clinical trials. At 8, 24 or 72 hr after treatment, tumors were excised and divided in half with one half processed for gene expression analysis, and the other half stained by immunohistochemistry for blood vessels (PECAM/CD31) and measured morphometrically for tumor vessel density. We found that expression levels of a number of vascular genes, including ICAM2, eNOS, and VE-cadherin, were decreased by VEGF Trap at 24 and 72 hr, but not at 8 hr. The time course and magnitude of the reduced expression of these genes correlated with the decrease in vessel density in the different tumor types, thus these genes may serve as markers of tumor vessel density. In comparison, expression levels of several other vascular genes, including Angiopoietin-2 and Nidogen2, were already decreased at 8 hr after treatment of multiple tumor types with VEGF Trap, and remained decreased at 24 and 72 hr. Expression of these latter genes appears to be dependent upon continued VEGF signaling, suggesting that these represent direct VEGF target genes. These results show that at least 2 phases of vascular gene expression changes can be discerned in tumors following VEGF blockade: the initial phase involves VEGF target genes and the latter phase involves constitutive endothelial cells genes. The most rapidly changed genes may provide biomarkers of VEGF-blockade, whereas the slower changing genes may be useful as indicators of overall tumor vascularity.
ReRAM‐Based Neuromorphic Computing (2016)

Artificial neural networks are intended to solve complex machine-learning tasks by using massive parallel data processing in a similar way as in biological neural systems. A recent approach to mimic biology is to emulate the basic processing elements directly in hardware. ReRAM devices are considered key elements to realize highly scalable, and low-power neuromorphic systems consist of using a hybrid analog–digital circuit approach. The specific properties of ReRAM devices that make those devices highly useful as artificial synapse are highlighted in detail. Especially, the multilevel capability of ReRAM devices enables the implementation of learning rules such as spike-timing-dependent plasticity (STDP). The scaling perspectives of ReRAM-based neuromorphic architectures are elaborated on, revealing a scaling potential below 10 nm. Finally, several neuromorphic applications using ReRAM architectures are reviewed and an evaluation of the future perspectives is given.
Genetic and Structural Analysis of the Bacteroides Conjugative Transposon CTn341 (2005)

The genetic structure and functional organization of a Bacteroides conjugative transposon (CTn), CTn341, were determined. CTn341 was originally isolated from a tetracycline-resistant clinical isolate of Bacteroides vulgatus. The element was 51,993 bp long, which included a 5-bp coupling sequence that linked the transposon ends in the circular form. There were 46 genes, and the corresponding gene products fell into three major functional groups: DNA metabolism, regulation and antibiotic resistance, and conjugation. The G + C content and codon usage observed in the functional groups suggested that the groups belong to different genetic lineages, indicating that CTn341 is a composite, modular element. Mutational analysis of genes representing the different functional groups provided evidence for the gene assignments and showed that the basic conjugation and excision genes are conserved among Bacteroides spp. A group IIA1 intron, designated B.f.I1, was found to be inserted into the bmhA methylase gene. Reverse transcriptase PCR analysis of CTn341 RNA showed that B.fr.I1 was functional and was spliced out of the bmhA gene. Six related CTn-like elements were found in the genome sequences of Bacteroides fragilis NCTC9343 and Bacteroides thetaiotaomicron VPI5482. The putative elements were similar to CTn341 primarily in the tra and mob regions and in the exc gene, and several appeared to contain intron elements. Our data provide the first reported sequence for a complete Bacteroides CTn, and they should be of considerable benefit to further functional and genetic analyses of antibiotic resistance elements and genome evolution in Bacteroides.
Optimization of design and microfabrication of metamaterial-based absorber for terahertz microbolometer (2014)

The sensitivity of uncooled microbolometer detectors to terahertz radiation can be significantly improved by enhancing the platform absorption. This paper presents the various aspects of design and optimization of metamaterial based frequency selective terahertz absorber. It also briefly discusses the microfabrication of terahertz microbolometer focal plane array which was recently developed at INO.
Robust variable-regularized RLS algorithms (2017)

The regularization parameter is required in most (if not all) adaptive algorithms, while its role becomes very critical in the presence of additive noise. In this paper, we focus on the regularized recursive least-squares (RLS) algorithm and present a method to find its regularization parameter, which is related to the signal-to-noise ratio (SNR). Also, using a proper estimation of the SNR, we further propose a variable-regularized RLS (VR-RLS) algorithm. In addition, a low-complexity version of the VR-RLS algorithm is developed, based on the dichotomous coordinate descent (DCD) method. Due to their nature, the proposed algorithms have good robustness features against additive noise, which make them behave well in all noisy conditions. Simulations performed in the context of acoustic echo cancellation support these findings.