gebhart/patrepeval huggingface dataset:
Mise en place d’une procédure de prise en charge des fractures du radius distal de type Pouteau-Colles (2014)

Objectif : Mise en place et évaluation d’une procédure de prise en charge des fractures de Pouteau-Colles dans un service d’urgences.\nMatériels et méthodes : Nous avons préalablement réalisé une procédure écrite et audiovisuelle fondée sur la littérature internationale. Cette procédure, réalisée avec nos collègues orthopédistes, aborde les pièges cliniques, l’interprétation des critères radiographiques de déplacement, les critères de choix entre un traitement conservateur et chirurgical, les indications et la technique de réduction, l’analgosédation et l’immobilisation. Nous avons analysé rétrospectivement le suivi de cette procédure.\nRésultats : Les dossiers de 106 patients présentant une fracture de Pouteau-Colles ont été revus parmi 174 fractures du radius distal. Soixante-et-une parmi ces 106 fractures (58 %) ont été décrites comme fractures déplacées et ont été immédiatement opérées (n = 32), réduites par les médecins des urgences (n = 20) ou plâtrées sans réduction (n = 9). Deux procédures de réduction sur vingt ont été considérées comme insuffisantes. La réalisation d’une sédation en vue de la réduction n’est mentionnée que chez dix des vingt patients.\nConclusion : La mise en place d’une procédure est le premier pas pour améliorer l’autonomie et la qualité de la prise en charge des fractures de Pouteau-Colles par les médecins urgentistes. Leur formation doit se poursuivre en s’aidant de technologies audiovisuelles et de formations pratiques.
D.TRUMP: Data-mining Textual Responses to Uncover Misconception Patterns (2017)

An important, yet largely unstudied, problem in student data analysis is to detect misconceptions from students' responses to open-response questions. Misconception detection enables instructors to deliver more targeted feedback on the misconceptions exhibited by many students in their class, thus improving the quality of instruction. In this paper, we propose a new natural language processing-based framework to detect the common misconceptions among students' textual responses to short-answer questions. We propose a probabilistic model for students' textual responses involving misconceptions and experimentally validate it on a real-world student-response dataset. Experimental results show that our proposed framework excels at classifying whether a response exhibits one or more misconceptions. More importantly, it can also automatically detect the common misconceptions exhibited across responses from multiple students to multiple questions; this property is especially important at large scale, since instructors will no longer need to manually specify all possible misconceptions that students might exhibit.
Weight change in depression: Influence of “disinhibition” is mediated by body mass and other variables (1991)

The direction of weight change (gain or loss) in depression has recently been found to be a stable characteristic of patients across depressive episodes. A search for determinants of the direction of weight change revealed two candidates: the body mass index (BMI) (weight in kilograms/height in meters squared) and a psychological variable, "disinhibition" of dietary restraint. The present study, of 68 patients with a history of recurrent depression, found a significant correlation between BMI and weight change; in other words, heavier persons were more likely to gain weight if depressed. There was also a correlation between "disinhibition" and weight change. "Disinhibition" correlated with BMI and, when controlled for BMI, age and sex, the correlation between "disinhibition" and weight change fell to insignificance. We conclude that BMI along with age and sex mediated the correlation between "disinhibition" and weight change.
Is Charge Sustaining Achievable in Electric Free-Floating Bicycle Sharing? (2020)

This paper explores the feasibility of a free-floating electric bicycle sharing system. They key enabling factor is to reduce the costs associated to recharging the batteries by applying the charge sustaining paradigm. The paper derives a model that describes the energy dynamics of a fleet of 300 bicycles. The model first guides the design of an Energy Management System and then quantitatively analyzes the feasibility of the bike-sharing system. In particular, we show that, although it is impossible to completely remove maintenance interventions, a rental rate of 2.5 picks per bicycle per day is enough to guarantee charge sustaining at the fleet level.
High Symbol Rate Coherent Optical Transmission Systems: 80 and 107 Gbaud (2014)

We demonstrate high speed optical transmission systems using digital coherent detection at all-electronically multiplexed symbol rates of 80 and 107 Gbaud. At 107 Gbaud, we demonstrate a single-carrier polarization division multiplexed quadrature phase shift keyed (PDM-QPSK) line rate of 428 Gb/s. At 80 Gbaud, we achieve a single-carrier line rate of 640 Gb/s using PDM 16-ary quadrature amplitude modulation (16-QAM). Using two optical subcarriers, we demonstrate a 1-Tb/s optical interface and conduct long-haul wavelength-division multiplexed (WDM) transmission on a 200-GHz grid over 3200 km of ultra-large effective area fiber.
Robust MIMO precoding for the schatten norm based channel uncertainty sets (2013)

In this paper, we consider robust MIMO precoding designs against deterministic imperfect channel state information at the transmitter (CSIT). In contrast to the existing works based on one or two particular channel uncertainty models, we consider a general uncertainty set defined by a generic matrix norm, called the Schatten norm, which includes most deterministic imperfect CSIT as special cases. Adopting worst-case robustness, the robust MIMO precoding design is formulated as a maximin problem to maximize the worst-case received signal-to-noise ratio or minimize the worst-case error probability. We show that the robust precoder admits a channel-diagonalizing structure for all Schatten norm based uncertainty sets, and then simplify the complex-valued matrix problem to a real-valued vector power allocation problem. We further show that the simplified power allocation problem can be analytically solved in a waterfilling manner, thus leading to a fully closed-form solution to the robust precoding design. Finally, we also investigate the robustness of beamforming and uniform-power transmission.
Synthetic infrared spectra for correlation spectroscopy (1997)

As a first step toward the development of a new remote sensing technique that the authors call holographic correlation spectroscopy, they demonstrate that diffractive optics can be used to synthesize the infrared spectra of real compounds. In particular, they have designed, fabricated, and characterized a diffractive element that successfully reproduces the major features f the spectrum of gaseous HF in the region between 3,600 cm{sup {minus}1} and 4,300 cm{sup {minus}1}. The reflection-mode diffractive optic consists of 4,096 lines, each 4.5 {micro}m wide, at 16 discrete depths relative to the substrate (from 0 to 1.2 {micro}m), and was fabricated on a silicon wafer using anisotropic reactive ion-beam etching in a four-mask-level process. The authors envision the use of diffractive elements of this type to replace the cumbersome reference cells of conventional correlation spectroscopy and thereby enable a new class of compact and versatile correlation spectrometers.
Situated interaction (2019)

research-article Situated interaction Share on Authors: Dan Bohus View Profile , Eric Horvitz View Profile Authors Info & Claims The Handbook of Multimodal-Multisensor Interfaces: Language Processing, Software, Commercialization, and Emerging DirectionsJuly 2019 Pages 105–143https://doi.org/10.1145/3233795.3233800Published:01 July 2019 1citation115DownloadsMetricsTotal Citations1Total Downloads115Last 12 Months10Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
628. An Oncolytic Adenovirus Armed with a GM-CSF Activating Designed Zinc-Finger Protein Transcription Factor: A Potential Cancer Vaccine Approach (2004)

Granulocyte macrophage colony stimulating factor (GM-CSF) is a potent activator of the immune system shown to enhance anti-tumor immune responses. We are inserting engineered zinc-finger protein transcription factors (ZFP TFs) up-regulating the expression of GM-CSF, into selectively-replicating oncolytic viral vectors, such as ONYX-411, in order to render them capable of acting as in vivo vaccines. In this system replication-dependent expression of the encoded ZFP TF transgene restricts expression to the appropriate cancer cells, while viral replication in these tumor cells results in local gene amplification and spread. GM-CSF secretion by infected tumor cells should stimulate an immune response against the tumor-specific antigens generated by the oncolytic action of the virus. This in turn is predicted to prime the immune system to direct the systemic elimination of tumor cells not reached by the armed therapeutic virus itself and thereby enhance its therapeutic efficiency.
Evaluating in vivo efficacy – toxicity profile of TEG001 in humanized mice xenografts against primary human AML disease and healthy hematopoietic cells (2019)

Within the limitations of humanized PD-X models, targeting CD277J by TEG001 is safe and efficient. Therefore, we have initiated clinical testing of TEG001 in a phase I first-in-human clinical trial (NTR6541; date of registration 25 July 2017).
Insights from the development of two generations of networked sensor and processor systems (2001)

A wirelessly networked array of integrated sensor and processing modules has demonstrated video-rate tomographic reconstruction previously shown on a video enabled supercomputer cluster. We discuss issues regarding design and development of these first- and second-generation distributed sensing and processing platforms.
Understanding Expressions of Unwanted Behaviors in Open Bug Reporting (2010)

Open bug reporting allows end-users to express a vast array of unwanted software behaviors. However, users’ expectations often clash with developers’ implementation intents. We created a classification of seven common expectation violations cited by end-users in bug report descriptions and applied it to 1,000 bug reports from the Mozilla project. Our results show that users largely described bugs as violations of their own personal expectations, of specifications, or of the user community’s expectations. We found a correlation between a reporter’s expression of which expectation was being violated and whether or not the bug would eventually be fixed. Specifically, when bugs were expressed as violations of community expectations rather than personal expectations, they had a better chance of being fixed.
Nickel-Fe3O4 Magnetic Nanoparticles Supported on Multiwalled Carbon Nanotubes: Effective Catalyst in Suzuki Cross Coupling Reactions (2021)

Nickel-Fe3O4 nanoparticles supported on multi-walled carbon nanotubes (Ni-Fe3O4/MWCNTs) were synthesized by mechanical grinding of a sample of nickel salt, Fe3O4 and MWCNTs using a ball-mill mixer. The preparation method allows for bulk production of Ni-Fe3O4 nanoparticles at room temperature without the necessity of any solvent or chemical reagent. The nanoparticles prepared by this method exhibit small particles size of 5–8 nm with uniform dispersion of nickel nanoparticles on the surface of multi-walled carbon nanotubes. The Ni-Fe3O4/MWCNTs demonstrated remarkable catalytic activity for Suzuki cross coupling reactions of functionalized aryl halides and phenylboronic acids with excellent turnover number and turnover frequency (e.g., 76,000 h−1) using Monowave 50 conventional heating reactor at 120 °C within a very short reaction time of 15 min. The catalyst is air-stable and exhibits easy removal from the reaction mixture due to its magnetic properties, recyclability with no loss of activity, and significantly better performance than the other well-known commercial nickel catalyst. The Ni-Fe3O4/MWCNTs nanoparticles were fully characterized by a variety of spectroscopic techniques including X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM) and X-ray Photoelectron Spectroscopy (XPS). Since nickel offers similar properties to other more expensive transition metals including the most widely used palladium counterpart in cross coupling catalysis, this work demonstrates a promising lower-cost, air-moisture stable and efficient alternative catalyst based on nickel nanoparticles for cross coupling reactions.
Development and underground test of radiopure ZnMoO4scintillating bolometers for the LUMINEU 0ν2β project (2015)

The LUMINEU (Luminescent Underground Molybdenum Investigation for NEUtrino mass and nature) project envisages a high-sensitivity search for neutrinoless double beta (0 nu 2 beta) decay of Mo-100 with the help of scintillating bolometers based on zinc molybdate (ZnMoO4) crystals. One of the crucial points for the successful performance of this experiment is the development of a protocol for producing high quality large mass ZnMoO4 crystal scintillators with extremely high internal radiopurity. Here we report a significant progress in the development of large volume ZnMoO4 crystalline boules (with mass up to 1 kg) from deeply purified materials. We present and discuss the results achieved with two ZnMoO4 samples (with mass of about 0.3 kg each): one is a precursor of the LUMINEU project, while the other one was produced in the framework of LUMINEU with an improved purification / crystallization procedure. The two crystals were measured deep underground as scintillating bolometers in the EDELWEISS dilution refrigerator at the Laboratoire Souterrain de Modane (France) protected by a rock overburden corresponding to 4800 m w.e. The results indicate that both tested crystals are highly radiopure. However, the advanced LUMINEU sample shows a clear improvement with respect to the precursor, exhibiting only a trace internal contamination related with Po-210 at the level of 1 mBq/kg, while the activity of Ra-226 and Th-228 is below 0.005 mBq/kg. This demonstrates that the LUMINEU purification and crystal-growth procedures are very efficient and leads to radiopurity levels which exceedingly satisfy not only the LUMINEU goals but also the requirements of a next-generation 0 nu 2 beta experiment.
New Sorbents for Olefin/Paraffin Separations and Olefin Purification for C4Hydrocarbons (1999)

New adsorbents for olefin/paraffin separations are synthesized by incipient wetness impregnation and ion exchange of Ag+ cations on high-surface-area substrates. The separation/purification is achieved by selective adsorption of olefins and/or dienes by π-complexation. It was shown that the monolayer AgNO3/SiO2 sorbent has a selective adsorption ratio of 8.33 for butene/butane at 70 °C and 1 atm. The isotherm linearity for olefin is ideally suited for cyclic adsorption−desorption processes. Moreover, the performance of the π-complexation sorbent (AgY zeolite) for the purification of butene by removal of trace amounts of butadiene was found to be superior to that of sorbents based on physical adsorption (5A zeolite and NaY). It was also shown that the Horvath−Kawazoe (H−K) model (using the Cheng−Yang version for spherical pores and correction for isotherm nonlinearity) is capable of predicting the adsorption behavior of the C4 hydrocarbons on 5A zeolite. Because the H−K model only involves dispersion forces, it underpredicts for gas−solid systems in which other forces also exist such as electrostatic and π-complexation. C4H6/C4H8 on 5A zeolite is one of these systems.
Propagating spatiotemporal activity patterns across macaque motor cortex carry kinematic information (2023)

Propagating spatiotemporal neural patterns are widely evident across sensory, motor, and association cortical areas. However, it remains unclear whether any characteristics of neural propagation carry information about specific behavioral details. Here, we provide the first evidence for a link between the direction of cortical propagation and specific behavioral features of an upcoming movement on a trial-by-trial basis. We recorded local field potentials (LFPs) from multielectrode arrays implanted in the primary motor cortex of two rhesus macaque monkeys while they performed a 2D reach task. Propagating patterns were extracted from the information-rich high-gamma band (200 to 400 Hz) envelopes in the LFP amplitude. We found that the exact direction of propagating patterns varied systematically according to initial movement direction, enabling kinematic predictions. Furthermore, characteristics of these propagation patterns provided additional predictive capability beyond the LFP amplitude themselves, which suggests the value of including mesoscopic spatiotemporal characteristics in refining brain-machine interfaces.
Morphology and adhesion of silicon nitride coatings upon soaking in fetal bovine serum (2018)

Total hip joint replacements are considered successful in providing patients with close- to-normal lives; however, revision surgeries still represent an individual and socioeconomic burden due to wear and failure of the implants, which occurs at a rate of 3-10% at 10 years. Therefore, eorts are being made to increase the lifespan of articial prostheses. Because of the impossibility to avoid wear debris, functional silicon nitride coatings are being developed due their low wearing, particle solubility and good biological response. However, a compromise needs to be found between coating reactivity and durability. A HIPIMS process was used to sputter a CrN interlayer followed by a SiNx top layer using 1- and 3-fold rotation in an industrial deposition system (CemeCon AG, Würselen, Germany). In order to measure the adhesion of the coatings to the cobalt-chromium-molybdenum substrates a scratch test was used, consisting of generating a scratch with a Rockwell C diamond stylus, at an increasing load from 0 to 100 N, at a displacement rate of 6mm/min. The samples were immersed in 25% fetal bovine serum solution to mimic synovial joint uid and scratched aer 0, 1, 3, 6 weeks periods in this solution. The cross-section of the coatings was assessed through Focused Ion Beam at 30kV for milling and 5kV for secondary electron imaging of the surface. The coatings demonstrated a high nitrogen content, previously shown to be benecial in terms of low dissolution rates. The deposition conditions and coating morphology were found to have an eect on the dissolution rate and thereby also the spallation failure of the coatings. These results are informative for the further development of these coatings into parts of functional 3D implants.
Chemchar process for destruction of sorbed hexachlorobenzene with char sorbent regeneration (1992)

The ChemChar reverse‐burn gasification process has been previously described1–2. In the present work, the ChemChar Process was evaluated to determine its effectiveness in regenerating spent activated coal char, as well as its destruction efficiency for the model surrogate compound hexachlorobenzene (HCB). This non‐incinerative, thermochemical gasification process pyrolyzes the sorbed wastes and restores the sorptive capacity of the char in one energy‐efficient step, that is virtually non‐polluting. A breakthrough assay method was used for analysis of the resultant reactivated char to determine its effectiveness as a sorbent after regeneration. The content of the gaseous effluent from the regeneration process was analyzed by GC‐MS and the destruction and removal efficiency was found to exceed 99.99% for the process. Analysis of the effluent from the process showed that potentially thermally‐synthesized hazardous products particularly polychlorinated dibenzo‐dioxins, and polychlorinated dibenzo‐furans, are absent. The process produces good quality regenerated char simply and inexpensively with a minimum of char loss, and the char can be regenerated several times.
Overlapped loop support in the Cydra 5 (1989)

The Cydra TM 5 architecture adds unique support for overlapping successive iterations of a loop to a very long instruction word (VLIW) base. This architecture allows highly parallel loop execution for a much larger class of loops than can be vectorized, without requiring the unrolling of loops usually used by compilers for VLIW machines. This paper discusses the Cydra 5 loop scheduling model, the special architectural features which support it, and the loop compilation techniques used to take full advantage of the architecture.
New Benzylureas as a Novel Series of Potent, Nonpeptidic Vasopressin V2 Receptor Agonists (2008)

Vasopressin (AVP) is a hormone that stimulates an increase in water permeability through activation of V2 receptors in the kidney. The analogue of AVP, desmopressin, has proven an effective drug for diseases where a reduction of urine output is desired. However, its peptidic nature limits its bioavailability. We report herein the discovery of potent, nonpeptidic, benzylurea derived agonists of the vasopressin V2 receptor. We describe substitutions on the benzyl group to give improvements in potency and subsequent modifications to the urea end group to provide improvements in solubility and increased oral efficacy in a rat model of diuresis. The lead compound 20e (VA106483) is reported for the first time and has been selected for clinical development.
Faculty Opinions recommendation of Evaluation of targeted next-generation sequencing-based preimplantation genetic diagnosis of monogenic disease. (2013)

OBJECTIVE: To investigate the applicability of next-generation sequencing (NGS) to preimplantation genetic diagnosis (PGD); to evaluate semiconductor-based NGS for genetic analysis of human embryos.DESIGN: Blinded.SETTING: Academic center for reproductive medicine.PATIENT(S): Six couples at risk of transmitting single-gene disorders to their offspring.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): Embryonic genotype consistency of NGS with two independent conventional methods of PGD.RESULT(S): NGS provided 100% equivalent PGD diagnoses of compound point mutations and small deletions and insertions compared with both reference laboratory- and internally developed quantitative polymerase chain reaction (qPCR)-based analyses. Furthermore, NGS single-gene disorder screening could be performed in parallel with qPCR-based comprehensive chromosome screening.CONCLUSION(S): NGS can provide blastocyst PGD results with a high level of consistency with established methodologies. This study and its design could serve as a model for further development of this important and emerging technology.Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. PMID: 23312231