gebhart/patrepeval huggingface dataset:
WEF/WERF Study Quantifying Nutrient Removal Technology Performance (2011)

The Water Environment Research Foundation (WERF) Nutrient Challenge Research Program and the Water Environment Federation (WEF) cooperated in a comprehensive study of nutrient removal plants designed and operated to meet very low levels of effluent N and P. Both existing and new technologies are being adapted to meet requirements that are as low as 3 mg/L TN and 0.1 mg/L TP, and there is a need to define their capabilities and reliabilities in the real world situation of wastewater treatment plants. This effort focused on maximizing what can be learned from existing technologies in order to provide a database that will inform key decision makers about proper choices for both technologies and rationale bases for statistical permit writing. To this end, managers of 22 plants, 10 achieving low effluent TP, 9 achieving low effluent TN, and 3 achieving low effluent ammonia, were asked to provide 3 years of operational data that were analyzed using a consistent statistical approach. Technical papers were compiled for each plant including a summary of influent loading, process design and operating conditions, unusual events, upsets and anecdotes related to process operation, and the statistical summary of final effluent data that considered both process reliability and the permit limits applied. The first year of this effort culminated in a workshop held in Chicago at WEFTEC 2008 and the second year in a workshop held in Orlando at WEFTEC 2009. Technological conclusions that can be drawn from the study in terms of what can be learned by comparing the different nutrient removal processes employed at these 22 plants and several additional BNR facilities in Florida are described in joint manuscripts submitted by Parker et al (2009) and Bott et al (2009). In a parallel effort using the data and conclusions generated from this study, Neethling et al (2009) proposed a set of quantitative descriptors that attempt to define the nutrient removal performance in terms of effluent quality percentile statistics referred to as Technology Performance Statistics (TPSs). The TPSs were defined as three separate values representing the lowest, median, and reliably achievable performance (Neethling et al, 2009).

This title belongs to WERF Research Report Series .

ISBN: 9781843393986 (Print)

ISBN: 9781780403328 (eBook)
Helix Sense-Selective Supramolecular Polymerization Seeded by a One-Handed Helical Polymeric Assembly (2015)

Helix sense-selective supramolecular polymerization was achieved using a one-handed helical nanotubular polymeric assembly as a seed. First, bipyridine (BPY)-appended achiral hexabenzocoronene ((BPY)HBC) was copolymerized noncovalently with chiral (BPY)HBC(S) (or (BPY)HBC(R)) at a molar ratio of 9:1, which, via the sergeants-and-soldiers effect, afforded a P-helical (or M-helical) nanotube, which was then treated with Cu(2+) to transform into structurally robust ((BPY)Cu)NT(P) (or ((BPY)Cu)NT(M)) with a Cu(2+)/BPY coordination polymer shell. Helical seeds ((BPY)Cu)NT(P) and ((BPY)Cu)NT(M) brought about the controlled assembly of fluorinated chiral FHBC(S) and FHBC(R) as well as achiral FHBC to yield one-handed helical nanotubular supramolecular block copolymers, in which the helical senses of the newly formed block segments were solely determined by those of the helical seeds employed. Noteworthy, FHBC(S) and FHBC(R) alone without the helical seeds form ill-defined agglomerates. Attempted supramolecular polymerization of a racemic mixture of FHBC(S) and FHBC(R) from ((BPY)Cu)NT(P) (or ((BPY)Cu)NT(M)) resulted in its chiral separation, affording P-helical (or M-helical) diastereomeric block segments composed of FHBC(S)and FHBC(R) with different thermodynamic properties.
Patients suffering from non-IgE-mediated cow’s milk protein intolerance cannot be diagnosed based on IgG subclass or IgA responses to milk allergens (2011)

Cow's milk protein intolerant patients cannot be distinguished from persons without cow's milk protein intolerance on the basis of IgG subclass or IgA reactivity to cow's milk allergens.
Pharmacokinetic Study of a Gallium‐porphyrin Photo‐ and Sono‐sensitizer, ATX‐70, in Tumor‐bearing Mice (2001)

The tissue distribution of a gallium-porphyrin photo- and sono-sensitizer, 7,12-bis(1-decyloxyethyl)-Ga(III)-3,8,13,17-tetramethylporphyrin-2,18-dipropionyldiaspartic acid, ATX-70, was pharmacokinetically examined in tumor-bearing mice. The drug was administered intravenously to CDF(1) mice implanted with Colon 26 carcinoma. Blood and tissue samples were collected for up to 72 h after administration. The drug concentration was determined by high-performance liquid chromatography (HPLC) with fluorescence detection. ATX-70 was found to accumulate in tumors at a relatively high concentration that peaked between 2 h and 6 h after administration. However, modest concentrations of ATX-70 also remained in healthy tissues for up to 6 h. We examined the distribution of ATX-70 in the tumor in comparison with other tissues from the viewpoint of minimizing possible side effects of laser or ultrasound exposure while maintaining the treatment effect. About 24 h after administration, the tumor / plasma concentration ratio peaked, and relatively high tumor / skin and tumor / muscle concentration ratios were seen.
Diamond-like film encapsulated fibers for long-length fiber grating production (2002)

We have developed a process to deposit a thin uniform layer of diamond-like film onto optical fibers. This UV-transparent film protects the fiber during the fiber grating inscription and maintains the geometry of the fiber so long length gratings can be fabricated.
Shedding Light on Immunotherapy for Cancer (2004)

There are two experimental approaches to treat cancer through tweaking the immune system; both depend on T lymphocytes' having access to tumor. A recent study involving a mouse model demonstrates the importance of accessibility and is thus relevant to both approaches.
Phase I Trial of a Therapeutic DNA Vaccine for Preventing Hepatocellular Carcinoma from Chronic Hepatitis C Virus (HCV) Infection (2022)

The administration of IL12 DNA along with a hepatitis C viral antigen DNA vaccine enhanced the HCV-specific immune responses induced by the vaccine in individuals with chronic hepatitis C, an important cause of hepatocellular carcinoma. IL12 could be an effective adjuvant in vaccines targeting HCV and other oncogenic viruses.
A Co-Association of Streptococcus mutans and Veillonella parvula/dispar in Root Caries Patients and In Vitro Biofilms (2022)

Root caries in geriatric patients is a growing problem as more people are maintaining their natural teeth into advanced age. We determined the levels of various bacterial species previously implicated in root caries disease or health using quantitative real-time PCR in a pilot study of 7 patients with 1 to 4 root caries lesions per person. Levels of 12 different species on diseased roots compared to healthy (contralateral control) roots were measured. Four species were found at significantly higher levels on diseased roots (Streptococcus mutans, Veillonella parvula/dispar, Actinomyces naeslundii/viscosus, and Capnocytophaga granulosa) compared across all plaque samples. The level of colonization by these species varied dramatically (up to 1,000-fold) between patients, indicating different patients have different bacteria contributing to root caries disease. Neither of the two species previously reported to correlate with healthy roots (C. granulosa and Delftia acidovorans) showed statistically significant protective roles in our population, although D. acidovorans showed a trend toward higher levels on healthy teeth (<i>P = </i>0.08). There was a significant positive correlation between higher levels of S. mutans and V. parvula/dispar on the same diseased teeth. <i>In vitro</i> mixed biofilm studies demonstrated that co-culturing S. mutans and V. parvula leads to a 50 to 150% increase in sucrose-dependent biofilm mass compared to S. mutans alone, depending on the growth conditions, while V. parvula alone did not form <i>in vitro</i> biofilms. The presence of V. parvula also decreased the acidification of S. mutans biofilms when grown in artificial saliva and enhanced the health of mixed biofilms.
Analytical and experimental study of the dynamics of a micro-electromechanical resonator based digital-to-analog converter (2021)

Abstract In this paper, an analytical model of a micro-electromechanical (MEM) resonator used as a 4-bit digital-to-analog converter (DAC) is presented. First, we derive the dynamic equation of the 4-bit DAC device, and the nonlinear governing equation is solved by the Galerkin method combined with a shooting technique to simulate the static response, linear eigenvalue problem, and forced vibration response of the device for various electrostatic actuation cases. Also, we optimize the air gaps in the linear domain to ensure enhanced performance of the DAC. Further, to analyze the operation of the DAC in the nonlinear regime, two experimental samples powered by −2 dBm and −12 dBm AC inputs are examined. Forward and backward frequency sweeps are conducted experimentally and analytically. The proposed analytical results are validated by comparison with experimental data. The results indicate that the presented modeling, simulations, and optimization are effective tools for the design of MEM resonator-based circuits.
Deterministic and Empirical Approach for Millimeter-Wave Complex Outdoor Smart Parking Solution Deployments (2021)

The characterization of different vegetation/vehicle densities and their corresponding effects on large-scale channel parameters such as path loss can provide important information during the deployment of wireless communications systems under outdoor conditions. In this work, a deterministic analysis based on ray-launching (RL) simulation and empirical measurements for vehicle-to-infrastructure (V2I) communications for outdoor parking environments and smart parking solutions is presented. The study was carried out at a frequency of 28 GHz using directional antennas, with the transmitter raised above ground level under realistic use case conditions. Different radio channel impairments were weighed in, considering the progressive effect of first, the density of an incremental obstructed barrier of trees, and the effect of different parked vehicle densities within the parking lot. On the basis of these scenarios, large-scale parameters and temporal dispersion characteristics were obtained, and the effect of vegetation/vehicle density changes was assessed. The characterization of propagation impairments that different vegetation/vehicle densities can impose onto the wireless radio channel in the millimeter frequency range was performed. Finally, the results obtained in this research can aid communication deployment in outdoor parking conditions.
The effect of a weak ferromagnetic matrix on a system of nanomagnetic particles (2005)

The study of system of magnetic nano-particle has received increasing attention recently both because of the novel physical concepts involved and also because of their vast potential for application. The influence of background material (the substrate coating) on magnetic properties of such systems is a relatively open topic and often a full understanding is missing. In the present work we discuss our experiments and interpretation for two systems: Ni nanoparticles coated with graphitic carbon and Ni nanoparticles coated with Au. While the latter system exibits behavior typical of superparamagnetic particle systems the former shows several puzzling results such as extremely high blocking temperature ($T_{B}$), very fast relaxation time well below $T_{B}$, temperature independent field-cooled magnetization and very small coercivity and remanent magnetization. We interpret these findings as being a result of weak ferromagnetism, characteristic of the graphitic carbon. This induces strong magnetic interactions between the Ni particles in the presence of small magnetic fields. Such systems give rise to a dramatic difference in blocking temperature between measurements performed at zero field and those performed at very small magnetic fields.
Low Voltage Direct Current Delivered Through Unipolar Transvenous Leads: An Alternate Method for the Induction of Ventricnlar Fibrillation (1999)

The induction of VF during testing of an ICD may not always be possible using either burst pacing or high energy T wave shocks. The purpose of this study was to evaluate the effectiveness of low energy DC stimulation for inducing VF in a porcine model. The VFT was measured using constant voltage stimuli and a step-up method in ten anesthetized pigs (25-30 kg). Stimuli of different durations (0.5, 1.0, 2.0 s) were delivered (unsynchronized) between a right ventricular apical coil and a subcutaneous test can. Current was measured from the voltage drop across a series resistor (10 omega). With anodal stimulation, VF required 6.4 +/- 0.2 V compared to 13.8 +/- 0.6 V with cathodal stimulation (P < 0.001). The current required to induce VF (measured 10 ms after the stimulus onset) was 58.3 +/- 2.2 mA with anodal stimulation and 119.3 +/- 4.7 mA with cathodal stimulation (P < 0.001). Stimulus duration did not significantly influence the voltage or current required for VF induction. In 6 of the 10 pigs, synchronizing a 0.5-second stimulus to the R wave did not significantly alter the VFT compared to same stimulus synchronized to mid-upslope of the T wave. The results indicate that VF can be consistently induced through transvenous electrodes by passing unsynchronized DC for 0.5-2 seconds. The induction of VF required about 50% less current and voltage with anodal stimulation. It should be possible to induce VF with the DC voltage available from the internal battery source of an ICD.
In vitro susceptibility of Trichomonas vaginalis to AT-specific minor groove binding drugs (2003)

Trichomoniasis is one of the most common sexually transmitted diseases, with around 120 million world-wide suffering from Trichomonas vaginalis-induced vaginitis every year. Although trichomoniasis can be treated with metronidazole, the prevalence of metronidazole-resistant T. vaginalis seems to be increasing. Since the percentage of AT base pairs in T. vaginalis DNA (71%) is very much higher than in human cells, in this study a series of bisquaternary quinolinium salt compounds with high AT-binding specificity were tested for their antitrichomonal activities. Minimum inhibitory concentrations (MICs) were determined for these compounds against a local strain of T. vaginalis in culture. Among 14 bisquaternary quinolinium compounds tested, an N-ethyl derivative was the most effective drug against T. vaginalis, being nearly as potent (MIC = 0.16 microM) as metronidazole (MIC = 0.096 microM), and with low toxicity towards human cells. The nature of the substitution at the quinolinium quaternary centre appears to be important in terms of effectiveness of bisquaternary compounds against the parasite. In contrast, no clear relationships could be seen for substituents on the quinolinium ring; Me and Cl substituted analogues showed higher activity against trichomonads, whereas OMe, NHMe and NH2 substituents decreased activity.
Faculty Opinions recommendation of UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans. (2013)

Synaptic transmission consists of fast and slow components of neurotransmitter release. Here we show that these components are mediated by distinct exocytic proteins. The Caenorhabditis elegans unc-13 gene is required for SV exocytosis, and encodes long and short isoforms (UNC-13L and S). Fast release was mediated by UNC-13L, whereas slow release required both UNC-13 proteins and was inhibited by Tomosyn. The spatial location of each protein correlated with its effect. Proteins adjacent to the dense projection mediated fast release, while those controlling slow release were more distal or diffuse. Two UNC-13L domains accelerated release. C2A, which binds RIM (a protein associated with calcium channels), anchored UNC-13 at active zones and shortened the latency of release. A calmodulin binding site accelerated release but had little effect on UNC-13's spatial localization. These results suggest that UNC-13L, UNC-13S, and Tomosyn form a molecular code that dictates the timing of neurotransmitter release.
Support U.S. research during COVID-19 (2020)

Colleges and universities are critical components of the U.S. innovation ecosystem. These institutions are called upon to play ever-evolving roles in building talent for a changing workforce; achieving scientific breakthroughs; creating new technologies, products, and companies; and contributing to local economic development. Yet, as the pace of change accelerates across our economy, federal and state budget constraints have made meeting these expectations increasingly challenging. The federal commitment to research and development stands at a multidecadal low as a percentage of GDP (1). Now, the coronavirus disease 2019 (COVID-19) pandemic has disrupted almost all aspects of higher education, including the ability to keep laboratories open, conduct research in a timely manner, collect and process data, and collaborate with colleagues and students.
Combined Inkjet Printing and Infrared Sintering of Silver Nanoparticles using a Swathe-by-Swathe and Layer-by-Layer Approach for 3-Dimensional Structures (2017)

Despite the advancement of additive manufacturing (AM)/3-dimensional (3D) printing, single-step fabrication of multifunctional parts using AM is limited. With the view of enabling multifunctional AM (MFAM), in this study, sintering of metal nanoparticles was performed to obtain conductivity for continuous line inkjet printing of electronics. This was achieved using a bespoke three-dimensional (3D) inkjet-printing machine, JETx, capable of printing a range of materials and utilizing different post processing procedures to print multilayered 3D structures in a single manufacturing step. Multiple layers of silver were printed from an ink containing silver nanoparticles (AgNPs) and infrared sintered using a swathe-by-swathe (SS) and layer-by-layer sintering (LS) regime. The differences in the heat profile for the SS and LS was observed to influence the coalescence of the AgNPs. Void percentage of both SS and LS samples was higher toward the top layer than the bottom layer due to relatively less IR exposure in the top than the bottom. The results depicted a homogeneous microstructure for LS of AgNPs and showed less deformation compared to the SS. Electrical resistivity of the LS tracks (13.6 ± 1 μΩ cm) was lower than the SS tracks (22.5 ± 1 μΩ cm). This study recommends the use of LS method to sinter the AgNPs to obtain a conductive track in 25% less time than SS method for MFAM.
ChemInform Abstract: Precursor‐Directed Biosynthesis of Erythromycin Analogues by an Engineered Polyketide Synthase (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Facile and Efficient Removal of Tungsten Anions Using Lysine-Promoted Precipitation for Recycling High-Purity Tungsten (2017)

We present a facile method for tungsten ion removal using lysine for the development of an environmentally friendly and sustainable recycling technique. Lysine addition to the tungsten solution achieved 100% tungsten removal within 5 min, as a white lysine–tungsten precipitate. Electrospray ionization mass spectrometry analyses of the tungsten and lysine mixed solutions showed that lysine promoted dehydration condensation reactions of anionic tungsten species such as HWO4– and W6O192– through the electrostatic interactions between positively charged lysine and negatively charged tungsten ions. Calcination of the lysine–tungsten precipitate produced tungsten oxide powder of high purity (99.6%) because the lysine is completely decomposed. This facile and useful metal removal method can be used for polyoxometalates of other metals such as molybdenum, tantalum, and niobium.
Incentives for Ridesharing: A Case Study of Welfare and Traffic Congestion (2021)

Traffic congestion is largely due to the high proportion of solo drivers during peak hours. Ridesharing, in the sense of carpooling, has emerged as a travel mode with the potential to reduce congestion by increasing the average vehicle occupancy rates and reduce the number of vehicles during commuting periods. In this study, we propose a simulation-based optimization framework to explore the potential of subsidizing ridesharing users, drivers, and riders, so as to improve social welfare and reduce congestion. We focus our attention on a realistic case study representative of the morning commute on Sydney’s M4 Motorway in Australia. We synthesize a network model and travel demand data from open data sources and use a multinomial logistic model to capture users’ preferences across different travel roles, including solo drivers, ridesharing drivers, ridesharing passengers, and a reserve option that does not contribute to congestion on the freeway network. We use a link transmission model to simulate traffic congestion on the freeway network and embed a fixed-point algorithm to equilibrate users’ mode choice in the long run within the proposed simulation-based optimization framework. Our numerical results reveal that ridesharing incentives have the potential to improve social welfare and reduce congestion. However, we find that providing too many subsidies to ridesharing users may increase congestion levels and thus be counterproductive from a system performance standpoint. We also investigate the impact of transaction fees to a third-party ridesharing platform on social welfare and traffic congestion. We observe that increasing the transaction fee for ridesharing passengers may help in mitigating congestion effects while improving social welfare in the system.