gebhart/patrepeval huggingface dataset:
Solution Deposition Approach to High&lt;tex&gt;$rm J_rm c$&lt;/tex&gt;Coated Conductor Fabrication (2005)

Great strides have been made in YBCO coated conductor fabrication using the RABiTS approach in the past few years and critical current densities (J/sub c/) of over 3 MA/cm/sup 2/ on 10 meter long tapes have been achieved. Solution deposition for buffer layer processing has the potential to reduce the process complexity and make the conductor fabrication more cost-effective. In our work, we have demonstrated that several of the standard buffer layers can be replaced by sol-gel processed lanthanum zirconium oxide (LZO) layer. A J/sub c/ of about 2 MA/cm/sup 2/ has been demonstrated on LZO films for pulsed laser deposited YBCO and J/sub c/ up to 1.5 MA/cm/sup 2/ have been demonstrated for MOD-YBCO using a sputtered CeO/sub 2/ cap layer on the sol-gel LZO films. Solution processed buffer layers have been found to have rapid growth kinetics which could potentially mean high rate processing of these buffer layers. Using simulated ex-situ YBCO annealing studies, it has been determined that the performance of 80-120 nm thick LZO films is comparable to the standard 3-layer vapor deposited CeO/sub 2//YSZ/Y/sub 2/O/sub 3/ buffer stack. Using a 120 nm thick LZO layers on NiW substrates, in collaboration with American Superconductor Corp., all-solution coated conductors with the stacking sequence MOD-YBCO/Solution CeO/sub 2//Solution LZO/NiW, critical currents of up to 140 A/cm has been measured. Such high critical currents on an all-solution conductor offers promise for cost-effective scale-up of coated conductor processing.
162 Dysregulated NO Signaling in the Lower Genitourinary Tract: A Common Mechanism of Erection and Micturition Dysfunction in a Mouse Model of Sickle Cell Disease (2018)

Sickle cell disease (SCD) is a state of chronic nitric oxide (NO) deficiency. Priapism, a disorder of non-willful, excessive penile erection, is a highly prevalent complication of SCD. The principal molecular defects underlying priapism in SCD include reduced NO/cGMP/PDE5 bioavailability in the penis related to decreased endothelial NO synthase (eNOS) activity. Recently, urinary dysfunction, including nocturnal enuresis and overactive bladder, have been clinically observed in SCD patients, but the mechanisms underlying urinary dysfunction in SCD are unknown. We hypothesized that aberration in NO regulatory signaling is a common pathophysiologic mechanism for concomitant erection and voiding disorders in SCD. 3 month old SCD (Sickle) and wild type (WT) male mice were used. Erectile function measurement (intracavernosal pressure/mean arterial pressure) and cystometric studies were performed. Bladder and urethra were collected from separate groups of Sickle and WT mice for organ bath studies or measurement of protein expressions of phospho (P)-eNOS (Ser-1177) and P-nNOS (Ser-1412) protein expression by Western immunoblot.
Comparison of the effects of millimeter wave irradiation, general bath heating, and localized heating on neuronal activity in the leech ganglion (2013)

The use of electrically-induced neuromodulation has grown in importance in the treatment of multiple neurological disorders such as Parkinson’s disease, dystonia, epilepsy, chronic pain, cluster headaches and others. While electrical current can be applied locally, it requires placing stimulation electrodes in direct contact with the neural tissue. Our goal is to develop a method for localized application of electromagnetic energy to the brain without direct tissue contact. Toward this goal, we are experimenting with the wireless transmission of millimeter wave (MMW) energy in the 10-100 GHz frequency range, where penetration and focusing can be traded off to provide non-contact irradiation of the cerebral cortex. Initial experiments have been conducted on freshly-isolated leech ganglia to evaluate the real-time changes in the activity of individual neurons upon exposure to the MMW radiation. The initial results indicate that low-intensity MMWs can partially <i>suppress</i> the neuronal activity. This is in contrast to general bath heating, which had an <i>excitatory</i> effect on the neuronal activity. Further studies are underway to determine the changes in the state of the membrane channels that might be responsible for the observed neuromodulatory effects.
Blind channel identification and equalization using periodic modulation precoders: performance analysis (2000)

The paper deals with blind identification and equalization of communication channels within the so-called modulation induced cyclostationarity (MIC) framework, where the input symbol stream is modulated by a P periodic precoder with the purpose of inducing cyclostationarity in the transmit sequence. By exploiting the cyclostationarity induced by the periodic precoder, a subspace-based channel identification algorithm that is resilient to the location of channel zeros, channel order overestimation errors, and color of additive stationary noise, is developed. The asymptotic performance of the subspace-based identification approach is analyzed and compared with the asymptotic lower bound provided by the nonlinear cyclic correlation matching approach. Criteria for optimally designing the periodic precoder are also presented. The performance of MMSE-FIR and MMSE-DFE equalizers is quantified for the proposed cyclostationarity-induced framework in terms of the MMSE. Although cyclostationarity-inducing transmitters present several advantages relative to their stationary counterparts from a channel estimation viewpoint, it is shown that from an equalization viewpoint, MIC-based systems exhibit a slightly increased MMSE/BER when compared with the stationary case.
Impaired immunological synapse in sperm associated antigen 6 (SPAG6) deficient mice (2016)

Sperm associated antigen 6 (SPAG6), a component of the central apparatus of the "9 + 2" axoneme, plays a central role in ciliary and flagellar motility; but, its contribution to adaptive immunity and immune system development is completely unknown. While immune cells lack a cilium, the immunological synapse is a surrogate cilium as it utilizes the same machinery as ciliogenesis including the nucleation of microtubules at the centrosome. This prompted our hypothesis that SPAG6 critically regulates the formation and function of immunological synapses. Using bone marrow reconstitution studies of adult WT mice, we demonstrate that SPAG6 is expressed in primary and secondary lymphoid tissues, is associated with the centrosome in lymphocytes, and its deficiency results in synapse disruption due to loss of centrosome polarization and actin clearance at the synaptic cleft. Improper synapse formation in Spag6KO mice was associated with defective CTL functions and impaired humoral immunity as indicated by reduced germinal centers reactions, follicular CD4 T cells, and production of class-switched antibody, together with expansion of B1 B cells. This novel report demonstrates the requirement of SPAG6 for optimal synapse formation and function, its direct role in immune cell function, and provides a novel mechanism for infertility disorders related to SPAG6.
Roadmap on structured light (2016)

Structured light refers to the generation and application of custom light fields. As the tools and technology to create and detect structured light have evolved, steadily the applications have begun to emerge. This roadmap touches on the key fields within structured light from the
Characterization of a multi-user indoor positioning system based on low cost depth vision (Kinect) for monitoring human activity in a smart home (2015)

An increasing number of systems use indoor positioning for many scenarios such as asset tracking, health care, games, manufacturing, logistics, shopping, and security. Many technologies are available and the use of depth cameras is becoming more and more attractive as this kind of device becomes affordable and easy to handle. This paper contributes to the effort of creating an indoor positioning system based on low cost depth cameras (Kinect). A method is proposed to optimize the calibration of the depth cameras, to describe the multi-camera data fusion and to specify a global positioning projection to maintain the compatibility with outdoor positioning systems. The monitoring of the people trajectories at home is intended for the early detection of a shift in daily activities which highlights disabilities and loss of autonomy. This system is meant to improve homecare health management at home for a better end of life at a sustainable cost for the community.
Frequency-Domain Equalization for Distributed Terrestrial DTV Transmission Environments (2006)

This paper presents a frequency-domain direct-inversion equalization method for DTV receivers to deal with 0 dB ghosts. To secure the existence of a channel inverse, channel-matched filtering and noncausal filtering are performed prior to equalization. Simulation results show that the proposed method has a comparable performance to the ideal DFE
Chromosomal distribution, localization and expression of the human endogenous retrovirus ERV9 (2001)

ERV9 is a class I family of human endogenous retroviral sequences. Somatic cell hybrid genomic hybridization experiments using a mono-chromosomal panel indicate the presence of approximately 120 ERV9 loci in the human genome distributed on most chromosomes. Fluorescence in situ hybridization (FISH) using an ERV9 cDNA probe containing gag, pol and env sequences, verified this observation and a consistent signal was found at the chromosome region 11q13.3-->q13.5. By analysis of a panel of radiation hybrids, an ERV9 locus was mapped to within a 300-kbp region at the chromosome site 11q13. The marker cCLGW567 and the locus MAP3K11/D11S546 centromeric and telomeric flanked it, respectively. Northern blot analysis, using an ERV9 LTR probe, indicated that most normal tissues examined expressed low abundant ERV9 LTR driven mRNAs of various sizes. The most prominent expression was found in adrenal glands and testis. However, the level of expression varied in the same tissues among different individuals indicating that ERV9 mRNA expression probably is inducible in certain tissues or at various cell stages.
Radiomics of MRI scans enables differentiation of benign from malignant soft tissue sarcoma. (2022)

11565 Background: Accounting for &gt;15,000 cases annually, soft tissue sarcomas (STSs) represent a large spectrum of tumors with varying histology and clinical course. However, diagnosis of STSs on MRI is challenging due to its heterogeneous imaging phenotypes, such as surrounding soft tissue edema, vascular lesion characteristics, and specific imaging signs, such as splitting of fat between muscles. The goal of this study was to evaluate the utility of radiomic feature analysis for characterizing subtle heterogeneity patterns on T2-weighted MRI to distinguish benign and malignant STSs. Methods: T2-weighted MRI of N = 176 patients with STS were retrospectively obtained from a single institution. (Table) Tumor regions were manually annotated by a radiologist. The radiomic features included textural features, e.g. gray-level co-occurrence matrix features, which quantify the correlation between textural patterns within annotated regions. Maximum relevance minimum redundancy feature selection was employed to identify top 10 radiomic features that are associated with STS malignancy. Then, the identified features were integrated to generate a radiomic risk score (RRS) via logistic regression on a 10-fold cross validation to differentiate benign and malignant STS. Multivariate analysis and the area under the receiver operating characteristic curve (AUC) were employed to evaluate the association of RRS and clinical parameters, including age, gender, and STS location, with STS malignancy. Results: Multivariate analysis illustrated that age and RRS are independent variables in predicting STS malignancy (p &lt; 0.05). The RRS yielded AUC as 0.76 (confidence interval (CI): 0.69-0.83), age 0.71 (CI: 0.64-0.79) and the combination of the RRS and age 0.84 (CI: 0.78-0.90). Conclusions: The RRS generated by radiomic features was found to be a significant predictor of STS malignancy. Furthermore, RRS could provide complementary information to the clinical parameters in differentiating benign and malignant STSs.[Table: see text]
SYNTHESIS OF 11-DEOXYANTHRACYCLINONE PRECURSOR. A NEW STRATEGY TOWARD TETRACYCLIC SYSTEM VIA TANDEM 1,4/[4+2] ADDITION (1983)

Abstract Direct and regioselective reaction of 2,4-pentadienyltrimethylstannane with 3-acryloyl-5-methoxy-1,4-naphthoqinone afforded a tetracyclic compound, a key precursor for synthesizing 11-deoxyanthracycline antibiotics, by single step.
Building Blocks for Polyamide Nucleic Acids: Facile Synthesis Using Potassium Fluoride Doped Natural Phosphate as Basic Catalyst. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Autoregulation of AbsB (RNase III) Expression in Streptomyces coelicolor by Endoribonucleolytic Cleavage of absB Operon Transcripts (2008)

The Streptomyces coelicolor absB gene encodes an RNase III family endoribonuclease and is normally essential for antibiotic biosynthesis. Here we report that AbsB controls its own expression by sequentially and site specifically cleaving stem-loop segments of its polycistronic transcript. Our results demonstrate a ribonucleolytic regulatory role for AbsB in vivo.
Theoretical System Capacity of Multi-User MIMO THP in the Presence of Terminal Mobility (2018)

This paper investigates the theoretical system capacity of multi-user multiple-input and multiple-output (MU-MIMO) Tomlinson-Harashima precoding (THP) in the presence of terminal mobility. Considering that MU-MIMO generally suffers from transmission performance degradation over time selective fading channels owing to terminal mobility, we incorporate the impact of mobility as well as the modulo loss peculiar to THP into the system capacity analysis. In particular, the multiuser interference (MUI) due to terminal mobility is theoretically derived and included as the undesired component in the mod- Λ channel required for analyzing the effect of the modulo loss. The proposed analysis enables a fair comparison in terms of the system capacity between THP and linear precoding (LP), and demonstrates the superiority of THP over LP in the presence of terminal mobility.
Time- and locally resolved photoluminescence of semipolar GaInN∕GaN facet light emitting diodes (2007)

The authors investigate the carrier lifetime and photoluminescence (PL) intensity of a semipolar GaInN∕GaN sample which was realized by growing five GaInN∕GaN quantum wells on the {11¯01} side facets of selectively grown n-GaN stripes that have a triangular shape running along the ⟨112¯0⟩ direction. Time- and locally resolved PL measurements show drastically reduced lifetimes for the semipolar sample of only 650ps at 4K whereas lifetimes exceeding 50ns were found for a polar reference sample. Furthermore, more than a doubling of the luminescence intensity and a significantly reduced blueshift of the PL peak wavelength with increasing excitation power density provide further evidence for the presence of reduced piezoelectric fields in the semipolar sample.
Biological Fate of Fe3O4 Core-Shell Mesoporous Silica Nanoparticles Depending on Particle Surface Chemistry (2017)

The biological fate of nanoparticles (NPs) for biomedical applications is highly dependent of their size and charge, their aggregation state and their surface chemistry. The chemical composition of the NPs surface influences their stability in biological fluids, their interaction with proteins, and their attraction to the cell membranes. In this work, core-shell magnetic mesoporous silica nanoparticles (Fe₃O₄@MSN), that are considered as potential theranostic candidates, are coated with polyethylene glycol (PEG) or 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayer. Their biological fate is studied in comparison to the native NPs. The physicochemical properties of these three types of NPs and their suspension behavior in different media are investigated. The attraction to a membrane model is also evaluated using a supported lipid bilayer. The surface composition of NPs strongly influences their dispersion in biological fluids mimics, protein binding and their interaction with cell membrane. While none of these types of NPs is found to be toxic on mice four days after intravenous injection of a dose of 40 mg kg<sup>-1</sup> of NPs, their surface coating nature influences the in vivo biodistribution. Importantly, NP coated with DMPC exhibit a strong accumulation in liver and a very low accumulation in lung in comparison with nude or PEG ones.
Differentiating wavefront orientation with unipolar cardiac electrograms (1988)

Unipolar electrograms recorded during propagation along the longitudinal axis of fibres differ in shape from those recorded following propagation across the transverse axis. maximum potentials and positive slopes before the intrinsic deflection and the peak-to-peak amplitudes and the negative slopes of the intrinsic deflection were shown to be significantly larger for longitudinal than for transverse propagation. These differences were significant for electrograms recorded during local activation alone and for those with superimposed distance activity. This information could be applied to increasing the information available from and thus the accuracy of cardiac maps.< <ETX>&gt;</ETX>
A General Approach to the Synthesis of β2‐Amino Acid Derivatives via Highly Efficient Catalytic Asymmetric Hydrogenation of α‐Aminomethylacrylates (2010)

Abstract A new strategy was developed for the synthesis of a valuable class of α‐aminomethylacrylates via the Baylis–Hillman reaction of different aldehydes with methyl acrylate followed by acetylation of the resulting allylic alcohols and S N 2′‐type amination of the allylic acetates. Asymmetric hydrogenation of these diverse olefinic precursors using rhodium(Et‐Duphos) catalysts provided the corresponding β 2 ‐amino acid derivatives with excellent enantioselectivities and exceedingly high reactivities (up to &gt;99.5% ee and S/C=10,000). The first hydrogenation of ( Z )‐configurated substrates was studied for the synthesis of β 2 ‐amino acid derivatives. The high influence of the substrate geometry and steric hindrance on the reactivity and enantioselectivity was also disclosed for this reaction. This protocol provides a highly practical, facile and scalable method for the preparation of optically pure β 2 ‐amino acids and their derivatives under mild reaction conditions.
Nanometer size effects on magnetic order in La1−xCaxMnO3 (x = 0.5 and 0.6) manganites, probed by ferromagnetic resonance (2012)

The data on X-band ferromagnetic resonance (FMR) in the half and electron-doped La0.5Ca0.5MnO3 (Ca0.5) and La0.4Ca0.6MnO3 (Ca0.6) nano-crystals and bulk ceramics are reported. The FMR data for considered nano-samples appeared to be strongly different, reflecting a difference in their magnetic/electronic order. An enhancement of the FMR signal intensities is observed in both nano Ca0.5 and Ca0.6 as compared to those in bulk. The peak intensity of such signal in nano Ca0.5 exceeds about two orders of magnitude the corresponding value in nano Ca0.6. This finding evidences on the respective ferromagnetic like and charge ordered antiferromagnetic ground states in Ca0.5 and Ca0.6.
HOW EFFICIENT NON‐DESTRUCTIVE CONTROLS OF FUSED‐CAST AZS WILL SUPPORT HIGH QUALITY GLASS MELTING (2022)

Latest trends in glass furnaces, towards clearer glasses and electrification, have underlined the importance of quality controls on AZS to extend furnace lifetime while maintaining good glass quality. The purpose of this paper is to describe three nondestructive control methods on refractories and their impact on furnace properties. Hence, we will describe how block color control is crucial to obtain good glass contact properties (blistering and exudation), how an optimized block filling, controlled thanks to radar waves, is required to maximize furnace lifetime and how optical tools enable reliable joint face analyses to ensure a limited corrosion inside joints. Finally, we will demonstrate that thanks to the ongoing digitalization of refractory manufacturing process and through these new measurements, SEFPRO will be able to offer refractory solutions to support the transition of glass melting technology towards low carbon processes and more severe conditions for refractory materials.
930. Muscle Stem Cells Deliver Dystrophin and Adopt a Cardiac Phenotype through Both Differentiation and Fusion in the Dystrophic (mdx) Heart (2004)

A reduction or absence of dystrophin protein in the heart will cause cardiac muscle degeneration and the progressive development of cardiomyopathy. In this study, we investigated the ability of a population of murine skeletal muscle–derived stem cells (MDSCs) to deliver dystrophin and acquire a cardiac phenotype after transplantation into the dystrophic (mdx) murine heart. The injected MDSCs engrafted and partially restored dystrophin expression within the dystrophic (mdx) myocardium for up to 12 weeks after implantation. In these hearts, approximately 3-5% of the donor-labeled cells expressed a cardiac phenotype, and more than half of these cells displayed a hybrid cardiac and skeletal muscle phenotype at 2, 4, 8 and 12 weeks after implantation. The majority of the donor cells expressing a cardiac phenotype were located along the periphery of the graft or within the host myocardium. Transplantation of female MDSCs into male recipient hearts revealed that the injected cells acquired a cardiac phenotype through both differentiation and fusion with host cardiomyocytes. The formation of fibrotic tissue within the injection site may have inhibited further acquisition of a cardiac phenotype by the implanted MDSCs. The results presented here support the potential use of MDSCs to advance muscle cell–based therapies for cardiac repair.
Cytology of human caudomedial cingulate, retrosplenial, and caudal parahippocampal cortices (2001)

Brodmann showed areas 26, 29, 30, 23, and 31 on the human posterior cingulate gyrus without marking sulcal areas. Histologic studies of retrosplenial areas 29 and 30 identify them on the ventral bank of the cingulate gyrus (CGv), whereas standardized atlases show area 30 on the surface of the caudomedial region. This study evaluates all areas on the CGv and caudomedial region with rigorous cytologic criteria in coronal and oblique sections Nissl stained or immunoreacted for neuron-specific nuclear binding protein and nonphosphorylated neurofilament proteins (NFP-ir). Ectosplenial area 26 has a granular layer with few large pyramidal neurons below. Lateral area 29 (29l) has a dense granular layer II-IV and undifferentiated layers V and VI. Medial area 29 (29m) has a layer III of medium and NFP-ir pyramids and a layer IV with some large, NFP-ir pyramidal neurons that distinguish it from areas 29l, 30, and 27. Although area 29m is primarily on the CGv, a terminal branch can extend onto the caudomedial lobule. Area 30 is dysgranular with a variable thickness layer IV that is interrupted by large NFP-ir neurons in layers IIIc and Va. Although area 30 does not appear on the surface of the caudomedial lobule, a terminal branch can form less that 1% of this gyrus. Area 23a is isocortex with a clear layer IV and large, NFP-ir neurons in layers IIIc and Va. Area 23b is similar to area 23a but with a thicker layer IV, more large neurons in layer Va, and a higher density of NFP-ir neurons in layer III. The caudomedial gyral surface is composed of areas 23a and 23b and a caudal extension of area 31. Although posterior area 27 and the parasubiculum are similar to rostral levels, posterior area 36' differs from rostral area 36. Subregional flat maps show that retrosplenial cortex is on the CGv, most of the surface of caudomedial cortex is areas 23a, 23b, and 31, and the retrosplenial/parahippocampal border is at the ventral edge of the splenium. Thus, Brodmann's map understates the rostral extent of retrosplenial cortex, overstates its caudoventral extent, and abridges the caudomedial extent of area 23.