gebhart/patrepeval huggingface dataset:
3D FEM Simulation of the Flow Forming Process Using Lagrangian and ALE Methods (2007)

The process of flow forming is numerically modeled using finite element codes based on the Forge2005® software. Two numerical approaches are considered. The first one uses an updated Lagrangian formulation. The problem is solved with help of a self‐contact management algorithm. The second approach consists in using an ALE formulation that permits to optimize meshing with an adaptive method based on the Zienkiewicz‐Zhu error estimation. The ALE method is well adapted to incremental forming processes such as flow forming and allows dealing with difficulties generated by the contact between the work piece and tools. Both formulations are coupled with complex tool kinematics. The Lagrangian formulation gives realistic results. The ALE formulation is promising with regard to computational time, and simulations on simple configurations show fairly good agreements with Lagrangian results.
Entstickung von Abgasen aus Magermixmotoren durch reversible Adsorption von N2O3 in Alkalimetall-Faujasit-Zeolithen (2000)

Das aus NO und NO2 gebildete N2O3 konkurriert mit Wassermolekülen um Koordinationsstellen der Natrium-Wasser-Netze in den Superkäfigen von Zeolith Na-Y. Infolgedessen ist die NOx-Adsorption durch diesen Zeolithen (siehe Bild) reversibel. Sie ist darüber hinaus unempfindlich gegenüber SO2 und bietet somit eine echte Alternative zu herkömmlichen Verfahren zur Entstickung von Autoabgasen durch Adsorption von oxidativ gebildetem Nitrat.
High power table-top THz free electron laser and its application (2009)

Recent progress of terahertz (THz) technology opens new applications of security inspection and biomedical developments. In some applications, the power of the THz radiation is crucial for the realization of the technology in the field. We have developed a laboratory-size high power free electron laser (FEL) and its application to THz imaging, spectroscopy, and material study. We found that a table-top FEL having more than 1-W power could be a source of a real-time imaging system for the security inspection. This paper introduces the design review of the table-top high-power THz FEL and its application potential to security inspection based on our KAERI THz FEL activities.
A Facile and Convenient Synthesis of some Novel Hydrazones, Schiff’s Base and Pyrazoles Incorporating Thieno[2,3-b]thiophenes (2011)

A facile and convenient synthesis of some novel hydrazones, schiff's base and pyrazoles from thieno[2,3-b]thiophene derivatives 1 have been achieved in high yields assisted by microwave and classical methods. The structures of all the title compounds have been elucidated by elemental analysis, IR, MS, (1)H-NMR and (13)C-NMR. Generally, these findings represent a new class of sulfur and nitrogen moieties that should also be of interest as new materials.
Capacity based MIMO antenna design (2017)

A Multi Element Antenna (MEA) is an array of antennas that can be driven independently so as to, among other things, mitigate adverse and variable propagation environment effects. MEAs are employed routinely by Multiple Input Multiple Output (MIMO) wireless systems and their effective radiation pattern is controlled by smart algorithms. As such, optimal MEA design cannot rely on traditional specifications like gain alone. This article outlines a Capacity based MEA design approach.
Search for gravitational waves from binary inspirals in S3 and S4 LIGO data (2008)

We report on a search for gravitational waves from the coalescence of compact binaries during the third and fourth LIGO science runs. The search focused on gravitational waves generated during the inspiral phase of the binary evolution. In our analysis, we considered three categories of compact binary systems, ordered by mass: (i) primordial black hole binaries with masses in the range $0.35{M}_{\ensuremath{\bigodot}}&lt;{m}_{1}$, ${m}_{2}&lt;1.0{M}_{\ensuremath{\bigodot}}$, (ii) binary neutron stars with masses in the range $1.0{M}_{\ensuremath{\bigodot}}&lt;{m}_{1}$, ${m}_{2}&lt;3.0{M}_{\ensuremath{\bigodot}}$, and (iii) binary black holes with masses in the range $3.0{M}_{\ensuremath{\bigodot}}&lt;{m}_{1}$, ${m}_{2}&lt;{m}_{\mathrm{max}﻿}$ with the additional constraint ${m}_{1}+{m}_{2}&lt;{m}_{\mathrm{max}﻿}$, where ${m}_{\mathrm{max}﻿}$ was set to $40.0{M}_{\ensuremath{\bigodot}}$ and $80.0{M}_{\ensuremath{\bigodot}}$ in the third and fourth science runs, respectively. Although the detectors could probe to distances as far as tens of Mpc, no gravitational-wave signals were identified in the 1364 hours of data we analyzed. Assuming a binary population with a Gaussian distribution around $0.75\ensuremath{-}0.75{M}_{\ensuremath{\bigodot}}$, $1.4\ensuremath{-}1.4{M}_{\ensuremath{\bigodot}}$, and $5.0\ensuremath{-}5.0{M}_{\ensuremath{\bigodot}}$, we derived 90%-confidence upper limit rates of $4.9\text{ }\text{ }{\mathrm{yr}}^{\ensuremath{-}1}{L}_{10}^{\ensuremath{-}1}$ for primordial black hole binaries, $1.2\text{ }\text{ }{\mathrm{yr}}^{\ensuremath{-}1}{L}_{10}^{\ensuremath{-}1}$ for binary neutron stars, and $0.5\text{ }\text{ }{\mathrm{yr}}^{\ensuremath{-}1}{L}_{10}^{\ensuremath{-}1}$ for stellar mass binary black holes, where ${L}_{10}$ is ${10}^{10}$ times the blue-light luminosity of the Sun.
De novo transcriptomes of 14 gammarid individuals for proteogenomic analysis of seven taxonomic groups (2019)

Gammarids are amphipods found worldwide distributed in fresh and marine waters. They play an important role in aquatic ecosystems and are well established sentinel species in ecotoxicology. In this study, we sequenced the transcriptomes of a male individual and a female individual for seven different taxonomic groups belonging to the two genera Gammarus and Echinogammarus: Gammarus fossarum A, G. fossarum B, G. fossarum C, Gammarus wautieri, Gammarus pulex, Echinogammarus berilloni, and Echinogammarus marinus. These taxa were chosen to explore the molecular diversity of transcribed genes of genotyped individuals from these groups. Transcriptomes were de novo assembled and annotated. High-quality assembly was confirmed by BUSCO comparison against the Arthropod dataset. The 14 RNA-Seq-derived protein sequence databases proposed here will be a significant resource for proteogenomics studies of these ecotoxicologically relevant non-model organisms. These transcriptomes represent reliable reference sequences for whole-transcriptome and proteome studies on other gammarids, for primer design to clone specific genes or monitor their specific expression, and for analyses of molecular differences between gammarid species.
Low-Temperature Conformal Atomic Layer Deposition of SiNx Films Using Si2Cl6 and NH3 Plasma (2015)

A plasma-enhanced atomic layer deposition (ALD) process was developed for the growth of SiNx thin films using Si2Cl6 and NH3 plasma. At substrate temperatures ≤400 °C, we show that this ALD process leads to films with >95% conformality over high aspect ratio nanostructures with a growth per cycle of ∼1.2 Å. The film growth mechanism was studied using in situ attenuated total reflection Fourier transform infrared spectroscopy. Our data show that on the SiNx growth surface, Si2Cl6 reacts with surface -NH2 groups to form surface -NH species, which are incorporated into the growing film. In the subsequent half cycle, radicals generated in the NH3 plasma abstract surface Cl atoms, and restore an NHx (x = 1,2)-terminated surface. Surface Si-N-Si bonds are also primarily formed during the NH3 plasma half-cycle. The infrared data and Rutherford backscattering combined with hydrogen forward scattering shows that the films contain ∼23% H atoms primarily incorporated as -NH groups.
Abstract 19230: Clinical Significance of Early Repolarization in Long QT Syndrome (2017)

Introduction: Early repolarization (ER) is associated with an increased risk of arrhythmic events and sudden cardiac death. There is limited data examining the clinical significance of ER in LQTS. The aim of our study was to therefore determine the prevalence of ER within a large cohort of patients with long QT syndrome (LQTS) and examine its clinical significance in terms of predicting symptoms and risk of breakthrough cardiac events (BCE). Methods: ER was defined as an end-QRS notch or slur on the downslope of a prominent R-wave with a J point ≥ 0.1 mV in 2 or more contiguous leads of the 12-lead ECG, excluding leads V1 to V3, with a QRS duration < 120 ms. The patient’s ECG with the most manifest ER was used for analysis. Major ER was defined as ≥ 2-mm J-point elevation. A patient was considered symptomatic if they had a suspected LQTS-triggered cardiac event prior to diagnosis (fetal arrhythmia, arrhythmogenic syncope/seizure, or cardiac arrest). BCEs were defined as LQTS-attributable syncope/seizures,...
Tissue distribution of target antigen has a decisive influence on the outcome of adoptive cancer immunotherapy (2002)

Adoptive transfer of allogeneic T cells has unmatched efficacy to eradicate leukemic cells. We therefore sought to evaluate in kinetic terms interactions between T cells and allogeneic leukemic cells. T cells primed against the model B6(dom1) minor histocompatibility antigen were adoptively transferred in irradiated B10 (B6(dom1)-positive) and congenic B10.H7(b) (B6(dom1)-negative) recipients, some of which were also injected with EL4 leukemia/lymphoma cells (B6(dom1)-positive). A key finding was that the tissue distribution of the target epitope dramatically influenced the outcome of adoptive cancer immunotherapy. Widespread expression of B6(dom1) in B10 recipients induced apoptosis and dysfunction of antigen-specific T cells. Furthermore, in leukemic B10 and B10.H7(b) hosts, a massive accumulation of effector/memory B6(dom1)-specific T cells was detected in the bone marrow, the main site of EL4 cell growth. The accumulation of effector/memory cells in recipient bone marrow was EL4 dependent, and its kinetics was different from that observed in recipient spleen. We conclude that strategies must be devised to prevent apoptosis of adoptively transferred T cells confronted with a high antigen load and that local monitoring of the immune response at the site of tumor growth may be mandatory for a meaningful assessment of the efficacy of adoptive immunotherapy.
Status of the PXIE Low Energy Beam Transport Line (2022)

A CW-compatible, pulsed H<sup>-</sup> superconducting RF linac (a.k.a. PIP-II) is envisaged as a possible path for upgrading Fermilab’s injection complex [1]. To validate the concept of the front-end of such machine, a test accelerator (a.k.a. PXIE) [2] is under construction. The warm part of this accelerator comprises a 10 mA DC, 30 keV H<sup>-</sup> ion source, a 2m-long LEBT, a 2.1 MeV CW RFQ, and a MEBT that feeds the first cryomodule. In addition to operating in the nominal CW mode, the LEBT should be able to produce a pulsed beam for both PXIE commissioning and modelling of the front-end nominal operation in the pulsed mode. Concurrently, it needs to provide effective means of inhibiting beam as part of the overall machine protection system. A peculiar feature of the present LEBT design is the capability of using the ~1m-long section immediately preceding the RFQ in two regimes of beam transport dynamics: neutralized and space charge dominated. This paper introduces the PXIE LEBT, reports on the status of the ion source and LEBT installation, and presents the first beam measurements.
Delineation of shift reagent-substrate equilibriums (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDelineation of shift reagent-substrate equilibriumsR. Porter, T. J. Marks, and D. F. ShriverCite this: J. Am. Chem. Soc. 1973, 95, 11, 3548–3552Publication Date (Print):May 1, 1973Publication History Published online1 May 2002Published inissue 1 May 1973https://doi.org/10.1021/ja00792a016RIGHTS & PERMISSIONSArticle Views36Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (526 KB) Get e-Alertsclose Get e-Alerts
ChemInform Abstract: PHOTOISOMERIZATION OF TRIQUINACENE CONGENERS (1977)

Abstract 2,3‐Dihydrotriquinacen (I) ergibt bei Belichtung in Benzol in Gegenwart von Aceton das Umlagerungsprodukt (II) in 40%iger Ausbeute.
Stereochemical and Electronic Control of Functionalized Tripodal Phosphines. Reactivity of the Adamantane-Type Ir(tripod)(CO)Cl (tripod = cis,cis-1,3,5-(PPh2)3-1,3,5-X3C6H6; X = H, COOMe, CN) Complexes toward H+, H2, CO, and C2H41 (1996)

Treatment of the tripodal phosphine ligand cis,cis-1,3,5-tris(diphenylphosphino)-1,3,5-tris(methoxycarbonyl)cyclohexane (tdppcyme) (2) with Ir(PPh3)2(CO)Cl gives the carbonyl chloro complex Ir(tdppcyme)(CO)Cl (2a). NMR spectroscopic investigations prove a dynamic equilibrium between a square-planar (2a‘) and a trigonal-bipyramidal (2a) complex with two and three phosphine groups coordinated to iridium, respectively. This is in contrast to the comparable complexes Ir(tripod)(CO)Cl (1a, 3a) [tripod = cis,cis-1,3,5-tris(diphenylphosphino)cyclohexane (tdppcy) (1), cis,cis-1,3,5-tricyano-cis,cis-1,3,5-tris(diphenylphosphino)cyclohexane (tdppcycn) (3)] which only exist in the trigonal-bipyramidal form. The three compounds Ir(tripod)(CO)Cl (1a−3a), which only differ in the functionalization of the ligand backbone, display altered basicity and thus different reaction patterns. The carbonyl chloro complexes 1a−3a are readily protonated by the strong acid HBF4 to give the octahedral cations 1b−3b. The weaker acid NH4PF6 is only able to protonate the most basic complex Ir(tdppcy)(CO)Cl (1a). While Ir(tdppcycn)(CO)Cl (3a) shows no reaction in the presence of NH4PF6, 2a is orthometalated to complex 2f‘. The compounds Ir(tdppcy)(CO)Cl (1a) and Ir(tdppcycn)(CO)Cl (3a) oxidatively add H2 with dissociation of Cl- to yield the octahedral dihydrides [Ir(tripod)(CO)(H)2]Cl (1c‘, 3c‘). Under the same conditions a phosphine arm dissociates from 2a to form the dihydride Ir(η2-tdppcyme)(CO)(H)2Cl (2c‘). In a CO atmosphere the Ir(tripod)(CO)Cl (1a−3a) complexes give the dicarbonyl derivatives [Ir(tripod)(CO)2]Cl (1d‘−3d‘). The dicarbonyls 2d‘ and 3d‘ are in an equilibrium with their starting materials. Replacement of the Cl- by BPh4- allows the isolation of all three dicarbonyl complexes. Treatment of 1a−3a with ethylene in the presence of NaBPh4 gives the ethylene complexes [Ir(tripod)(CO)(C2H4)]BPh4 (1e−3e). Variable-temperature NMR studies show that there is an exchange process which equilibrates the equatorial with the apical phosphorus nuclei while the CO and ethylene ligands remain rigid. In the cases of 2e and 3e a second dynamic process with a low-energy barrier exists. Above 45 and 35 °C, respectively, 1e and 2e lose ethylene and are orthometalated to 1f and 2f. The cyclometalated products 1f and 2f can also be obtained by the direct reaction of 1a and 2a with NaBPh4. For the dicarbonyl complex 3a and the orthometalated product 2f X-ray structure determinations have been performed.
ChemInform Abstract: Pd—NHC Catalyzed Conjugate Addition versus the Mizoroki—Heck Reaction. (2011)

Abstract The Pd(0)—NHC‐catalyzed reaction of various Michael acceptors with aryl iodides can afford either the conjugate addition, e.g. (III), (VIII) and (X), or Mizoroki—Heck products, e.g. (IV) and (XI), depending on the base applied.
Sirtuin gene isoforms and genomic sequences of mouse and humans: Divergence across species (2022)

Abstract Background There are seven sirtuin genes in the mammalian genome. Each sirtuin gene contains multiple exons, and is likely to undergo alternative splicing, thereby increasing sirtuin gene diversity. Since the alternatively spliced isoforms tend to increase with advancing age, it is important to study the effect of sequence change on isoform function. Additionally, the divergence of isoform patterns between human and mouse will help us to properly interpret the findings from animal models, especially in age-related studies. Recently, more than 20 human sirtuin isoforms have been identified, but whether the mouse genome might have similar isoforms remains incompletely established. Methods The mRNA, protein and genomic DNA sequences of mouse sirtuin genes, as well as the transcription factor binding sites, including that of SRF, were analyzed. A cellular stress model with serum deprivation and restoration was used to reflect the blood supply and nutrients level changes in the ischemia and reperfusion condition, and the expression of sirtuin isoform was assessed. Results Here, we report the identification of 15 mouse sirtuin isoforms, of which over half have not been previously reported. Exon skipping was the main event, which led to domain losses in the nuclear localization signal, nucleolar localization signal, and/or the mitochondrial targeting sequence among sirtuin isoforms. Among 7 sirtuin genes, 6 mouse sirtuin genes had different exon numbers versus that of human sirtuin genes. Only the sirtuin-2 gene had the same number of exons in both human and mouse. However, there were differences in the sirtuin-2 gene isoforms and the regulatory domains between the two species. The expression of sirtuin gene isoforms under serum stress was also different. Conclusions Alternative splicing increases both sirtuin transcriptome and proteome diversity. However, the sirtuin isoforms were not well conserved between human and mouse, which should be taken into consideration when extrapolating animal studies for human physiology and pathology. Our results will help to elucidate the role of sirtuin genes in the regulation of cellular stress response, including ischemia and reperfusion. We propose that the existence of the CArG and CArG-like sequences in sirtuin genes may imply a role for SRF in the sirtuin family transcriptional regulation.
Sequence and developmental expression ofAmphiTob, an amphioxus homolog of vertebrateTob in thePC3/BTG1/Tob family of tumor suppressor genes (1997)

Tob is a member of the PC3/ BTG1/Tob family of vertebrate tumor suppressor genes; its expression is known to inhibit proliferation of cells in vitro, but its possible roles during normal development have not been investigated previously. The present study concerns the structure and developmental expression of AmphiTob in an invertebrate chordate, amphioxus. This is the first investigation of any Tob gene during embryological development. The 311 amino acid AmphiTob protein is similar to vertebrate Tob but lacks the C-terminal PQ-rich domain of the latter. In early embryos of amphioxus, in situ hybridization first reveals AmphiTob expression in the hypoblast at the gastrula stage on the likely dorsal side of the embryo. During subsequent development, expression is seen in several tissues of the ectoderm, mesoderm, and endoderm. The most striking expression domains are in the developing somitic musculature and dorsal nerve cord. In the medial wall of each somite, AmphiTob is expressed strongly by cells destined to differentiate into the axial trunk muscles; this pattern persists until late in the larval stage, evidently because undifferentiated cells are continually becoming myogenic as the muscles grow. Nerve cord cells conspicuously transcribe AmphiTob from the late neurula until the early larval stage: Expression occurs in a few cells scattered along the nerve cord and in a group of cells located in the cerebral vesicle (in a region presumably homologous to the vertebrate diencephalic forebrain). During development, an intense and transitory transcription of AmphiTob may be an early event in cells exiting the cell cycle in preparation for differentiation.
Effects of the stereochemical orientation of phenethylamines and imidazolines on α‐adrenergic receptor‐mediated dna synthesis in primary cultured rat hepatocytes (1992)

The hepatic alpha 1-adrenergic receptor mediates a variety of hepatic functions including respiration, glycogenolysis, gluconeogenesis, and growth. We have utilized a rat primary hepatocyte culture system to show that the alpha 1-adrenergic receptor can be activated in a stereoselective manner by a series of phenethylamines and catecholimidazolines resulting in the stimulation of DNA synthesis as determined by [3H]thymidine incorporation. The phenethylamines adhered to the Easson-Stedman hypothesis with a rank order of potency of (-)-(R)-norepinephrine (NE) greater than (+)-(S)-NE greater than the desoxy analog dopamine (DA) for the stimulation of DNA synthesis. However, the 2-substituted catecholimidazolines did not follow this trend and demonstrated an order of potency of the desoxy analog 3,4-dihydroxybenzyl imidazoline (DHT) greater than or equal to (-)-(R)-2-(3,4,alpha-trihydroxybenzyl)imidazoline (TBI) greater than (+)-(S)-TBI. 4-Substituted catecholimidazolines were less potent as inducers of DNA synthesis than the corresponding 2-substituted analogs with an order of potency of (+)-(R)-4-(3,4-dihydroxybenzyl)imidazoline (DBI) greater than (+,-)-(R,S)-DBI greater than (-)-(S)-DBI. When the beta-hydroxyl moiety of NE is replaced with an amino group as in 3,4-dihydroxyphenylethylenediamine, the isomers are less active than the beta-hydroxylated analogs and also demonstrate no stereoselectivity for the stimulation of DNA synthesis. These results demonstrate that the hepatic alpha 1-adrenergic receptor can recognize various isomeric forms of these compounds and that hepatocellular growth can be modulated in a stereoselective manner by phenethylamines and imidazolines.
Helmet use and reduction in skull fractures in skiers and snowboarders admitted to the hospital (2011)

Among hospitalized children who sustained a head injury while skiing or snowboarding, a significantly lower number of patients suffered a skull fracture if they were wearing helmets at the time of the injury.
Cold sensitivity of the SARS-CoV-2 spike ectodomain (2020)

The SARS-CoV-2 spike (S) protein, a primary target for COVID-19 vaccine development, presents its Receptor Binding Domain in two conformations: receptor-accessible "up" or receptor-inaccessible "down" conformations. Here, we report that the commonly used stabilized S ectodomain construct "2P" is sensitive to cold temperature, and that this cold sensitivity is resolved in a "down" state stabilized spike. Our results will impact structural, functional and vaccine studies that use the SARS-CoV-2 S ectodomain.
Design and Implementation of a General-Purpose API of Progress and Performance Indicators. (2007)

In High Performance Computing centers, queuing systems are used by the users to access and manage the HPC resources through a set of interfaces. After job submission, users lose control of the job and they only have a very restricted set of interfaces for accessing data concerning the performance and progress of job events. In this paper we present a general-purpose API to implement progress and performance indicators of individual applications. The API is generic and it is designed to be used at different levels, from the operating system to a grid portal. We also present two additional components built on top of the API and their use in the HPC-Europa portal. Furthermore, we discuss how to use the proposed API and tools in the eNANOS project to implement scheduling policies based on dynamic load balancing techniques and self tuning in run time. 1
PROTEUS: a high-performance parallel-architecture simulator (1992)

No abstract available.