gebhart/patrepeval huggingface dataset:
Susceptibility of influenza A viruses to amantadine is influenced by the gene coding for M protein (1978)

Influenza A virus recombinants derived from "resistant" and "sensitive" parental viruses were examined for susceptibility to inhibition by amantadine. Correlation of gene constellation and amantadine susceptibility revealed that the gene coding for M protein influences sensitivity or resistance to amantadine. All recombinants which derived an M protein from an amantadine-resistant parent were found to be resistant to amantadine. All amantadine-sensitive recombinants derived an M gene from the amantadine-sensitive parent. However, a few amantadine-resistant recombinants which derived an M gene from the sensitive parent were also isolated, suggesting that the expression of amantadine sensitivity in these recombinants may be influenced by other genes.
High-temperature processable carbon–silicate nanocomposite cold electron cathodes for miniature X-ray sources (2012)

We report on the fabrication, Raman characterization and electron emission behavior of cold electron cathodes that are specifically designed to be used in miniature X-ray sources. The cathodes are fabricated by screen-printing a nanocomposite paste comprising multiwall carbon nanotubes as fillers in a matrix of graphite, glass and bentonite clay. The cathodes can resist high temperatures up to 880 °C and, as such, can survive most high-temperature brazing steps required for vacuum-tight sealing of the sources. We demonstrate peak emission current densities around 300 mA cm−2 at an applied electric field of 175 kV cm−1 and stable emission around 50 mA cm−2 at 125 kV cm−1 for at least 5 hours without significant degradation. X-rays were successfully generated at 3.2 watts of peak power (80 μA, 40 kV) with a commercial X-ray tube modified to accommodate a paste cathode.
Essential Oil Composition of the Inflorescence ofArtemisia capillarisThunb. Collected at Different Stages of Flowering from Kumaon Region of Western Himalaya (2010)

Abstract The essential oils obtained from Artemisia capillaris at different stages of flowering were analyzed by GC and GC/MS. The main components of this oil were capillene, γ-terpinene, eugenol, limonene, p-cymene, myrcene and α-pinene. Capillene (40.1%), α-pinene (2.4%) and p-cymene (2.5%) were higher in the oil obtained from plants collected during full bloom stage, while γ-terpinene (24.6%) and eugenol (15.0%) were the main components of the oil from the seed setting stage. Characteristic of the oil was the presence of the rarely occurring compounds like capillene and norcapillene.
High data rate acoustic telemetry for moving ROVs in a fading multipath shallow water environment (2002)

A compact telemetry system for digital data telemetry at rates up to 10 kb/s over 1 to 10 km is presented. The system is designed for worst-case ocean acoustic channel conditions, and operates in the presence of source/receiver motion, fading, and multiple transmission paths. In addition, the system incorporates spatial diversity by utilizing multiple hydrophones and data processing subsystems. This allows much more reliable operation under realistic circumstances where noise events and transducer masking are unavoidable. The result is a system specifically geared toward use at sea with a remotely operated vehicle (ROV). Preliminary dockside test results are presented to demonstrate the effectiveness of this multichannel system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
All-fiber STED microscopy illumination system (2016)

We demonstrate all-fiber STED illumination using vortex fiber modes excited via fiber gratings. The grating’s high purity mode conversion (98.7%) yields a depletion beam with 20.5dB extinction ratio, and the schematic is resistant to fiber bends down to 6mm radius.
α‐Fluorotricarbonyl Derivatives as Versatile Fluorinated Building Blocks: Synthesis of Fluoroacetophenone, Fluoroketo Ester and Fluoropyran‐4‐one Derivatives (2020)

Fluorinated acyl‐Meldrum's acid derivatives were synthesized by electrophilic fluorination of appropriate phenacyl Meldrum's acid substrates using Selectfluor. Reactions with water, ethanol, Grignard, and alkynyllithium reagents gave rise to the corresponding fluoro‐acetophenone, –1,3‐keto ester, –1,3‐diketone and ‐pyran‐4‐one products respectively from the same selectively fluorinated scaffold in one‐step procedures.
Photovoltaically powered modulating retroreflectors (2004)

The development of a photovoltaically (PV) powered, laser communication system that constitutes a miniature, highly energy-efficient wireless communication technology is described. The technology is based on the direct integration of a multi-quantum well (MQW) modulating retroreflector (MRR) optical communication node and a monolithically integrated module (MIM) PV power source. The MQW MRR optical data link exploits the shift in the MQW absorption peak under an applied reverse bias to modulate incident laser light enabling binary encoding of data for transfer. A MIM consists of many individual solar cells monolithically integrated on a single substrate and offers the design versatility necessary to allow efficient electrical conversion of both incident sunlight and the system laser-light and the ability to match the voltage output to the MRR requirements. A description of the development of the MRR and MIM components of the system along with the power management and distribution circuitry is given. Results of bench-top demonstrations of the operational system are presented.
Why Size Matters: Feature Coding as Nystrom Sampling (2013)

Recently, the computer vision and machine learning community has been in favor of feature extrac-tion pipelines that rely on a coding step followed by a linear classifier, due to their overall simplicity, well understood properties of linear classifiers, and their computational efficiency. In this paper we propose a novel view of this pipeline based on kernel methods and Nyström sampling. In particular,
A compact model for Phase Change Memories (2006)

In this paper we present the first inherently single-piece model describing the phase change memories (PCM) electrical behavior. The model correctly reproduces for all bias and temperature conditions the behavior of both SET and RESET states, including the exponential pre-switching regime and the S-shaped negative differential resistance region. The model responds with resistance changes to different programming (SET or RESET) pulses, and retains the stored data. The proposed model provides a precious tool for the design of non-volatile memory products based on the new phase change memory concept
Effect of porosity and surface chemistry on the characterization of synthetic polymers by HPLC using porous polymer monolithic columns (2002)

Monolithic 50×4.6 mm ID poly(styrene-co-divinylbenzene), poly(glycidyl methacrylate-co-ethylene dimethacrylate), and poly(2,3-dihydroxypropyl methacrylate-co-ethylene dimethacrylate) columns have been tested in the high-performance liquid chromatography (HPLC) separation of polystyrenes and poly(methyl methacrylate) standards. The separation process involves precipitation of the macromolecules on the macroporous monolithic column followed by progressive redissolution and elution utilizing a gradient of the mobile phase. While very good separations of individual components of mixtures of both polystyrenes and poly(methyl methacrylates) can be readily achieved using poly(styrene-co-divinylbenzene) monolith, methacrylate-based columns do not afford good separations under identical conditions. This unexpected finding appears to be the result of significant differences between the porous properties and chemistries of the two types of monolithic materials.
Integration of linear variable filters on CMOS for compact emission and absorption sensing (2016)

A compact optical spectrometer approach is presented that integrates multiple linear variable filters (LVFs) onto a CMOS imaging sensor for measurement of liquid-phase fluorescence and absorption that provides a 3.77-6.08 nm spectral resolution over a 400-1050 nm wavelength range. For fluorescence detection, we demonstrate detection limits of 0.28 nM for Quantum Dot emitters and 32 ng/mL for near-infrared fluorescent dyes. For colorimetric absorption detection, the system provides detection limits comparable to those obtained with a conventional spectrometer and a laboratory optical spectrum analyzer (OSA). As an exemplary application, we utilize the instrument for quantification of the concentration of chlorine in water.
MicroRNA-128-3p-mediated depletion of Drosha promotes lung cancer cell migration (2017)

Alteration in microRNAs (miRNAs) expression is a frequent finding in human cancers. In particular, widespread miRNAs down-regulation is a hallmark of malignant transformation. In the present report, we showed that the miR-128-3p, which is up-regulated in lung cancer tissues, has Drosha and Dicer, two key enzymes of miRNAs processing, as the main modulation targets leading to the widespread down-regulation of miRNA expression. We observed that the miRNAs downregulation induced by miR-128-3p contributed to the tumorigenic properties of lung cancer cells. In particular, miR-128-3p-mediated miRNAs down-regulation contributed to aberrant SNAIL and ZEB1 expression thereby promoting the epithelial-to-mesenchymal transition (EMT) program. Drosha also resulted to be implicated in the control of migratory phenotype as its expression counteracted miR-128-3p functional effects. Our study provides mechanistic insights into the function of miR-128-3p as a key regulator of the malignant phenotype of lung cancer cells. This also enforces the remarkable impact of Drosha and Dicer alteration in cancer, and in particular it highlights a role for Drosha in non-smallcell lung cancer cells migration.
UROLITHIASIS, ENDOUROLOGY AND LAPAROSCOPY (2002)

No AccessJournal of UrologyUROLOGICAL SURVEY: Abstracts1 May 2002UROLITHIASIS, ENDOUROLOGY AND LAPAROSCOPY Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65148-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 167Issue 5May 2002Page: 2313-2320 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement PDF DownloadLoading ...
Three-dimensional particle imaging by defocusing method with an annular aperture (2008)

We propose an annular-aperture-based defocusing technique for three-dimensional (3D) particle metrology from a single camera view. This simple configuration has high optical efficiency and the ability to deal with overlapped defocused images. Initial results show that an uncertainty in depth of 23 microm can be achieved over a range of 10 mm for macroscopic systems. This method can also be applied in microscopy for the measurement of fluorescently doped microparticles, thus providing a promising solution for 3D flow metrology at both macroscales and microscales.
Efficacy and side effects of intermittent intravenous and oral doxercalciferol (1alpha-hydroxyvitamin D(2)) in dialysis patients with secondary hyperparathyroidism: a sequential comparison. (2001)

Most reports on the effectiveness and side effects of oral versus parenteral calcitriol or alfacalcidol in hemodialysis patients with secondary hyperparathyroidism show no advantage of parenteral treatment. The efficacy and safety of intravenous doxercalciferol (1alphaD(2)) were studied in hemodialysis patients with secondary hyperparathyroidism (plasma intact parathyroid hormone [iPTH]: range, 266 to 3,644 pg/mL; median, 707 pg/mL). These results were compared with those of a previous trial using intermittent oral 1alphaD(2); the same 70 patients were entered onto both trials, and 64 patients completed both trials per protocol. Twelve weeks of open-label treatment in both trials were preceded by identical 8-week washout periods. Degrees of iPTH suppression from baseline were similar in the two trials, with iPTH level reductions less than 50% in 89% and 78% of patients during oral and intravenous treatment, respectively. Grouping patients according to entry iPTH levels (<750 and >/=750 pg/mL) showed similar but more rapid iPTH suppression in the low-iPTH groups, whereas longer treatment and larger doses were required by the high-iPTH groups. Highest serum calcium levels averaged 9.82 +/- 0.14 and 9.67 +/- 0.11 mg/dL during oral and intravenous 1alphaD(2) treatment, respectively (P: = not significant [NS]). Prevalences of serum calcium levels greater than 11.2 mg/dL during oral and intravenous treatment were 3.62% and 0.86% of calcium measurements, respectively (P: < 0.001). Highest serum phosphorus levels during oral and intravenous treatment averaged 5.82 +/- 0.21 and 5.60 +/- 0.21 mg/dL, respectively (P: = NS). The percentage of increments in serum phosphorus levels during oral treatment exceeded that during intravenous treatment during 5 of 12 treatment weeks. Thus, intermittent oral and intravenous therapy with 1alphaD(2) reduced iPTH levels effectively and similarly, hypercalcemia was less frequent, and serum phosphorus levels increased less during intravenous than oral 1alphaD(2) therapy, suggesting that intravenous 1alphaD(2) therapy may be advantageous in patients prone to hypercalcemia or hyperphosphatemia.
The Application of Cheminformatics in the Analysis of High-Throughput Screening Data (2016)

Although high-throughput screening (HTS) has become a common method of identifying chemical starting points for drug discovery programs, the evaluation of hit sets and ultimate selection of one or more chemical series to be optimized is often a labor intensive, and somewhat arbitrary, process. In this chapter, we will outline some of the techniques we have adopted for the computational analysis of HTS results, and demonstrate how these techniques have been integrated into an internally developed software tool, the HTS Viewer.
Tunable all-optical pulse compression and stretching via doublet Brillouin gain lines in an optical fiber (2009)

Stimulated Brillouin scattering (SBS) can amplify the light propagating in a direction opposite to the pump light. It has many applications such as optical amplification, lasing, optical fiber sensor, optical phase conjugation, slow light generation and stored light. In the case of slow light generation via SBS, tunable all optical delay lines via SBS using an optical fiber have been demonstrated [1], which shows that SBS delay line is a promising candidate for all-optical buffers in optical communication system. For all the Brillouin slow light systems, time delay is always accompanied by the pulse distortion. To reduce the pulse distortion effects, Brillouin slow light system based on doublet gain lines was suggested by Stenner et al [2]. Very recently, Schneider et al [3] reported zero-broadening Brillouin slow light in an optical fiber while accompanying with large pulse distortion.
HuMax-CD38, a new human CD38 monoclonal antibody, effectively mediates killing of multiple myeloma and plasma cell leukemia cells (2009)

Multiple myeloma (MM), a malignant disorder of the B cell lineage is characterized by neoplastic proliferation of plasma cells in the bone marrow. Current treatment regimens exhibit moderate response rates. However, only marginal changes in overall survival are observed and the median survival is approximately 3 years. There is – thus - a critical unmet medical need for treatment of MM. All malignant MM tumor cells demonstrate high CD38 expression, and as such CD38 represents a potential target for immunotherapy. HuMax-CD38, a human IgG1 antibody, was generated by immunizing human Ig transgenic mice. Immuno fluorescence studies showed binding of HuMax- CD38 to CD38-transfected CHO cells, several CD38-expressing cell lines and freshly isolated MM tumor cells. In addition, the ability of HuMax-CD38 to induce tumor cell death via several mechanisms such as antibody-dependent cell-mediated cytotoxicity (ADCC), and complementdependent cytotoxicity (CDC) was tested. Using mononuclear cells as effectors, HuMax-CD38 induced ADCC of several CD38- expressing B cell lines, and MM cell lines. More importantly, HuMax-CD38 mediated ADCC of tumor cells freshly isolated from bone marrow of MM patients, and also triggered ADCC of freshly isolated tumor cells from a patient with a rare CD38/CD138 – positive, chemotherapy- refractory, plasma cell leukaemia. In addition, HuMax- CD38 induced CDC of primary MM cells, freshly isolated from a cohort of 13 MM patients. The ability of HuMax-CD38 to reduce outgrowth of human lymphoma cells was tested in vivo in a SCID mouse xenograft model. HuMax- CD38 effectively inhibited tumor growth, both in a preventive as well as a therapeutic setting.
THE MOLECULAR AND ORGANISMAL BASIS OF RESILIENCE AND FRAILTY (2017)

A major goal of global aging research is to prevent frailty and promote resilience in aging in older adults around the world. Key to this effort is the identification of physiological and molecular etiologies that impact the health and well- being of older adults. Over the past two decades, increasing evidence suggests that age and environment related impaired stress response systems such as the innate immune system and the renin-angiotensin system, as well as neuroendocrine and endocrine system changes help to drive organismal frailty and related vulnerability to chronic diseases and adverse health outcomes. Maintenance of these same systems promotes resiliency and robustness. Specific age-related molecular changes are thought to drive these declines, including the development of senescent cell populations, mitochondrial dysfunction, and altered autophagy. In this symposium, speakers will 1) describe the conceptualization of frailty and resiliency with aging and provide an overview of the physiological systems thought to be most influential to these processes, 2) describe the endocrine changes and how they influence mitochondrial, autophagy, and mTOR pathways, 3) describe the role of cellular senescence to these processes, 4) review the animal models used for biological discovery in this area, and 5) outline the novel biological discoveries from the European FRAILOMICS consortium. At the end of this symposium, the audience will be able to describe age-related frailty and resiliency, their biological and physiological underpinnings, and the use of animal models and omic strategies that will further that biological understanding.
Role of Cyclic Ether and Solvent in a Non-Alkoxide Sol−Gel Synthesis of Yttria-Stabilized Zirconia Nanoparticles (2006)

The effects of cyclic ether (epoxide versus oxetane), solvent, and drying method were examined for a non-alkoxide sol−gel synthesis of yttria-stabilized zirconia (YSZ). YSZ sol−gel materials, from 3 to 25 mol % Y2O3, were successfully prepared with either propylene oxide (PO) or trimethylene oxide (TMO) in both aqueous and mixed ethanol−water solutions of Zr4+ and Y3+ chlorides. Supercritical drying (aerogels) produced fine, nanoparticulate networks, whereas drying under ambient conditions (xerogels) resulted in heterogeneous micrometer-sized hard agglomerates. The resulting materials were characterized using powder X-ray diffraction (XRD), Raman spectroscopy, transmission electron microscopy, scanning electron microscopy, nitrogen adsorption/desorption analysis, and elemental analysis by inductively coupled plasma−atomic emission spectroscopy. The cyclic ether and solvent were found to be critical factors in the resulting as-prepared aerogel surface area and morphology. For a given solvent, aerogels prepared with PO had higher surface areas than did those prepared with TMO. For example, the surface areas of aerogels prepared in water were 453 and 295 m2/g for PO and TMO, respectively. Following calcination to 550 °C, however, the crystallized YSZ powders were similar, consisting of homogeneous nanoparticles (∼10 nm) with spherical morphologies and high surface areas (>100 m2/g). Elemental analysis, XRD, and electron microscopy indicated that Y2O3 and ZrO2 formed a homogeneous nanostructure over a wide range of Zr/Y ratios, corresponding to 3−25 mol % Y2O3.
Investigation of a channel-add/drop-filtering device using acceptor-type point defects in a two-dimensional photonic-crystal slab (2003)

A channel-drop-filtering device using point and line defects in a two-dimensional photonic-crystal slab is investigated. The efficiency to drop light from a line-defect waveguide to the free space via a point-defect cavity is found to be more than 45%, which is very close to the theoretical maximum of the device. The reverse function of the device (channel-add-filtering) is also demonstrated, where photons incident on a point defect from free space are resonantly trapped and transferred to a line-defect waveguide nearby. The spectrum and polarization characteristic of the add-filtering completely agree with those of the drop-filtering. The results indicate that two-dimensional photonic slabs are very promising for realizing ultrasmall optical functional devices.
Supplementary Table S1 from Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer (2023)

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Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients (2009)

PURPOSE: Histologic findings in 51 pancreata resected from patients with a strong family history of pancreatic cancer were compared with the findings in 40 pancreata resected from patients with sporadic pancreatic cancer. None of the patients in the familial group had a known inherited syndrome other than familial pancreatic cancer. EXPERIMENTAL DESIGN: Precursor lesions, including pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and incipient IPMN, were quantified. Invasive cancers were classified using established histologic criteria. RESULTS: The individual precursor lesions identified in both groups were histologically similar. Precursor lesions were more common in the familial cases than in the sporadic cases. The relative rate of PanINs per square centimeter was 2.75-fold higher (95% confidence interval, 2.05-3.70; adjusted for age) in familial compared with sporadic cases. PanIN-3 lesions were more common in familial versus sporadic pancreatic cancer patients (relative rate, 4.20; 95% confidence interval, 2.22-7.93; adjusted for age). High-grade incipient IPMNs were only observed in the familial cases. Nine of the 51 (18%) familial pancreatic cancers and 4 of the 40 (10%) sporadic cancers arose in association with an IPMN. No significant differences were found in the types of invasive cancers. CONCLUSIONS: Noninvasive precursor lesions are more common in patients with a strong family history of pancreatic cancer than in patients with sporadic disease, and precursor lesions are of a higher grade in patients with a strong family history of pancreatic cancer. These findings can form a basis for the design of screening tests for the early detection of pancreatic neoplasia. (Clin Cancer Res 2009;15(24):7737-43).
Supplementary Fig. S4 from A selective small-molecule nuclear factor-κB inhibitor from a high-throughput cell-based assay for “activator protein-1 hits” (2023)

Supplementary Fig. S4 from A selective small-molecule nuclear factor-κB inhibitor from a high-throughput cell-based assay for “activator protein-1 hits”