gebhart/patrepeval huggingface dataset:
SINR Prediction Versus Reverse Reporting for Soft Reuse and Interference Management (2011)

We investigate inter-cell interference management based on two methods: instantaneous signal-to-interference plus noise (SINR) prediction and reverse reporting. Reverse reporting, a concept where vulnerable receivers announce themselves, is a common approach. SINR prediction is an alternative solution which brings the decision responsibility to the receiver. This has a positive effect on the system performance as receiver has more crucial information at its disposal than the transmitter. The paper proposes a protocol with both SINR prediction and reverse reporting as interference management phases implemented by sounding the channel with orthogonal sequences, but focuses mainly on situations when only one of them is active. We simulate the two approaches in WINNER based indoor scenario and compare them in terms of spectral efficiency and user fairness. SINR prediction comes out superior as it achieves significantly higher spectral efficiency for the price of only small decrease in fairness.
A Method for Improving the Efficiency of Transparent Film Antennas (2008)

This letter presents an optically transparent antenna, which is made of conductive AgHT coated film, with an improved efficiency by applying a highly conductive coating or metallization in the form of a very narrow strip to selective antenna areas of high current density. A measurement showed that the proposed method improved the maximum gain of a fabricated transparent antenna using the AgHT film from -5 dBi to 0 dBi at 2.2 GHz while preserving much of the optical transparency. A 3D electromagnetic model using a full-wave method of moments was developed to investigate the effect of width of the highly conductive narrow strip on the efficiency of the transparent antenna.
Development of ATP-Competitive mTOR Inhibitors (2011)

The mammalian Target of Rapamycin (mTOR)-mediated signaling transduction pathway has been observed to be deregulated in a wide variety of cancer and metabolic diseases. Despite extensive clinical development efforts, the well-known allosteric mTOR inhibitor rapamycin and structurally related rapalogs have failed to show significant single-agent antitumor efficacy in most types of cancer. This limited clinical success may be due to the inability of the rapalogs to maintain a complete blockade mTOR-mediated signaling. Therefore, numerous efforts have been initiated to develop ATP-competitive mTOR inhibitors that would block both mTORC1 and mTORC2 complex activity. Here, we describe our experimental approaches to develop Torin1 using a medium throughput cell-based screening assay and structure-guided drug design.
4-Watt Ka-Band AlGaN/GaN Power Amplifier MMIC (2006)

A broadband Ka-band AlGaN/GaN on SiC HEMT power amplifier MMIC was developed for millimeter-wave antenna applications. The output stage is composed of a 1.2-mm-wide device with 0.18 mum gate length. The two-stage 50-ohm matched MMIC produces 13plusmn1 dB of gain from 26 GHz to 36 GHz. At 35 GHz, the measured CW saturated output power was 4 W, indicating a power density of 3.3 W/mm. The power added efficiency was 23%. Across the band, the measured CW output power was > 2 W. While individual (or partially matched single stage) devices have been demonstrated with good output power, to the best of our knowledge, this is the first report of a 10 GHz-bandwidth Ka-band GaN MMIC with high output power, gain, and return loss
Measurement of Hydrogen Sulfide Metabolites Using the Monobromobimane Method (2022)

Hydrogen sulfide (H 2 S) has been studied for over 250 years, and its role has expanded from that of a toxic gas to be the third important gasotransmitter. Historically, it has been challenging to accurately and reliably detect bioavailable sulfide in vivo or in vitro . We have studied and reported numerous aspects of the monobromobimane (MBB) method involving derivatization of bioavailable sulfide with excess MBB to produce sulfide-dibimane (SDB). The resultant fluorescent SDB is measured by RP-HPLC using fluorescence detector with the low limit of detection for SDB (2 nM) or by LC/MS allowing lower detection limits. This gold standard method can provide an acceptable measurement of bioavailable sulfide, which is a useful and powerful tool.
Gentherapie der septischen Granulomatose: Chancen und Risiken. Der Weg zur erfolgreichen Therapie einer angeborenen Immundefizienz (2011)

Abstract Im Jahre 2004 sind am Universitätsklinikum Frankfurt zwei Patienten mit X‐CGD gentherapeutisch behandelt worden. Nach einer initialen Phase mit Nachweis ausreichender Mengen Oxidase‐positiver Zellen im Blut der Patienten und einer deutlichen klinischen Besserung vorbestehender Infektionsherde kam es zu einem Verlust der Transgenexpression durch epigenetische Veränderungen des viralen Promotors. Ferner entwickelte sich durch Insertionsmutagenese eine klonale Expansion in der Hämatopoese und schließlich ein myelodysplastisches Syndrom mit Monosomie 7 bei beiden Patienten. In der Zusammenschau mit anderen Gentherapiestudien zur X‐CGD zeigt sich, dass bislang ein langanhaltendes Engraftment funktionierender genkorrigierter Zellen nur im Zusammenhang mit einer Insertionsmutagenese beobachtet wurde. Zukünftige gentherapeutische Strategien zur Behandlung der X‐CGD müssen das Risiko einer Insertionsmutagenese minimieren und gleichzeitig die Effektivität des Engraftments genkorrigierter Zellen steigern. Dies soll durch den Einsatz von SIN‐Vektoren sowie einer Intensivierung der Konditionierung der Patienten erreicht werden.
A review on the synthesis, structure and applications in separation processes of mesoporous MSU-X silica obtained with the two-step process (2005)

We present a general review on the synthesis of mesoporous silica obtained with nonionic surfactants and bloc-copolymers as templates. This silica, referred as MSU silica, was obtained by a two-step process that led to the formation of stable hybrid micelles after a first stage of assembling between silica and surfactants, followed by the fluoride-catalyzed condensation of silica. This process allows some unique features: the final pore size can be adjusted with some synthesis parameters such as temperature or amount of catalyst, the particle shape is spherical and in the micrometric range, different shapes and nanostructures can be achieved, including hexagonal-like frameworks. Finally, we demonstrate how an accurate control of the synthesis itself may allow us to adapt this synthesis for applications dedicated to separation processes, including liquid filtration of HPLC chromatography.
Near-threshold voltage design in nanoscale CMOS (2013)

Summary form only given. New technologies have led to an “explosion” of data available to document states and processes in very many fields. Tools of data mining are being used to extract relevant information. If this information is used in decision making, analytical statistics can provide formal tests comparing the outcomes of different scenarios. Statistics has traditionally dealt with limited information, both in terms of observations and numbers of variables explaining the states of these observations. Virtually all statistical hypothesis testing was developed for such scenarios, trying to make sense from limited data, often expensive to produce. Clinical trials and the steps in development of drugs before those clinical trials are a typical examples from human medicine.
Investigation of Ray Tracing accuracy in street cell environment in high-SHF band (2014)

Recently, mobile networks employing high-speed high-capacity communications have been investigated extensively to satisfy the demand for the faster and larger data communication. As one of the approaches, High-SHF (6-30 GHz) and EHF (mainly 30-60 GHz) bands are the candidates to utilize the relatively wide frequency band widths. As one approach, High-SHF (6-30 GHz) and EHF (mainly 30-60 GHz) bands are candidates to utilize the relatively wide frequency bandwidths. Accordingly, the characteristics of radio propagation loss in the frequency bands must be characterized. We investigate the characteristics of radio propagation loss in a street cell environment in the High-SHF bands using Ray Tracing (RT) based on measurement results. We observe that RT calculation tends to exhibit estimation error as the frequency increases.
Introductory Commentary on Involvement of E-Cadherin in the Development of Erythroid Cells, Armeanu et al. (2000)

"Introductory Commentary on Involvement of E-Cadherin in the Development of Erythroid Cells, Armeanu et al.." Hematology, 5(4), p. 305
Quantitative Assessment of Mass Flow Boundaries in Continuous Twin-screw Granulation (2016)

In pharmaceutical manufacturing, there is an increasing interest in continuous manufacturing. As an example for fast continuous processes in general of considerable complexity, this study was focussed on improving the understanding of twin-screw wet granulation. The impact of the liquid-to-solid (L/S) mass flow ratio on product quality (granules) as well as on downstream process operations (tableting) was investigated in detail. Initially two methods were used to define L/S ratio boundaries for the granulation regime in twin-screw wet granulation. It was shown that the first method, which is based on measuring the wet granule mass flow variation, can be used to define the upper L/S ratio boundary of the granulation regime. The second method, based on measuring the granule size distribution, can be used to define the lower L/S ratio boundary of the regime. Using these methods, the granulation regime for different formulations could be established. This information was then used to show that the formulation could be optimised such that the process is more robust (i.e. wider L/S ratio boundaries for the granulation regime). Also it could be used to optimise the formulation considering further downstream processing such as drying (using as little water as possible to reduce drying efforts) or tableting (obtain granules with optimised tableting properties). Preferably, the process should be performed close to the lower L/S ratio boundary of the granulation regime. In summary, these tools enabled the quantitative establishment of granulation regime boundaries in a twin-screw wet granulation process and can be used to optimise formulation and to create a robust process. Analogies to other continuous processes in completely different applications can be conceived.
Manipulation of TH17 responses in pulmonary immunity and disease through vaccination (2009)

Since the discovery of a novel subset of CD4(+) T helper cells, T(H)17 cells have been implicated in a wide range of human diseases, including autoimmunity, allergic reactions and autoinflammatory diseases. Conversely, it has also been determined that T(H)17 cells are required to mount a protective immune response to a number of pathogens. It has therefore been of great interest to manipulate T(H)17 responses to either prevent disease or promote immunity. Vaccination is a particularly attractive approach for this manipulation. With a focus on the pulmonary mucosal environment, we herein review T(H)17 responses and potential methods for manipulation.
Vehicular RF Convergence: Simultaneous Radar, Communications, and PNT for Urban Air Mobility and Automotive Applications (2020)

Modern RF environments are becoming increasingly congested. This limits the opportunities and capabilities of modern RF systems, obstructing the development and proliferation of new technologies. Novel vehicular RF technologies promise a new era of transportation capabilities, but legacy design techniques cannot adapt to the current spectral congestion. We summarize recent RF Convergence results and discuss how they mitigate spectral congestion in modern vehicular applications. We propose a joint radar, communications, positioning, navigation, and timing (JRCPNT) system architecture as a suitable candidate for future automotive applications. We present relevant performance bounds and initial experimental results to demonstrate the potential performance enhancements of such multiple-function RF systems. We define multiple-channel, multiple-user receiver (MCMUR) techniques that enable this architecture and discuss how these components cooperate to enable these performance enhancements. We summarize initial experimental results to demonstrate the viability of such multiple-function architectures in the context of urban air mobility (UAM) and other automotive applications.
Use of gas-emissions from garbage-pits as energy-source (1983)

Still about 70% of the household-garbage in the Federal Republic of Germany (=14 mio t/a) are deposited without any kind of reprocessing. The organic mass contained therein (about 25-40% of the weight) remains active for a period of about 50 more years, according to today's knowledge. In collaboration with microcultures gas-mixtures of high methane content and therewith usable heat content are developed. Nature, quantity and use of such garbage-gases are investigated for the pit 'Vereinigte Ville'/Koeln by the author.
Altered migration of gut-derived T lymphocytes after activation with concanavalin A (1999)

Although activation of lymphocytes is known to be associated with profound changes in homing behavior, it remains unclear how activation alters migration of gut-derived lymphocytes in lymphoid and nonlymphoid organs. The objectives of this study were 1) to compare migration of naive and concanavalin A (ConA)-activated T lymphocytes into the gut mucosa, spleen, and liver and 2) to define the role of specific adhesion molecules in this homing process. Fluorescently labeled T lymphocytes collected from rat intestinal lymph were injected into the jugular vein, and the kinetics of appearance of the infused lymphocytes were monitored in ileal Peyer's patches, spleen, and liver. The migration of naive and ConA-activated T lymphocytes into microvessels were compared using an intravital microscope. ConA stimulation significantly increased the rolling velocity of T lymphocytes in postcapillary venules of Peyer's patches, and ConA-stimulated lymphocytes exhibited a loss of the selective adherence properties in Peyer's patches that is normally observed with naive T cells. ConA activation also suppressed the accumulation of T cells in the spleen. On the other hand, the adherence of T cells to hepatic sinusoidal endothelium was significantly increased after ConA activation, especially in the periportal area, and this increase was attenuated by an anti-intercellular adhesion molecule (ICAM)-1 antibody. Flow cytometry analysis revealed a decline in L-selectin expression and an increase in CD11a expression and ICAM-1 on the surface of ConA-treated T cells. In conclusion, activation of gut-derived T lymphocytes with ConA significantly alters their migration path, with a diminished localization to Peyer's patches and spleen and a preferential accumulation in hepatic sinusoids. This altered migration pattern likely results from changes in the expression of leukocyte adhesion molecules such as L-selectin and CD11a.
Structure of a eukaryotic thiaminase I (2013)

Thiaminases, enzymes that cleave vitamin B1, are sporadically distributed among prokaryotes and eukaryotes. Thiaminase I enzymes catalyze the elimination of the thiazole ring moiety from thiamin through substitution of the methylene group with a nitrogenous base or sulfhydryl compound. In eukaryotic organisms, these enzymes are reported to have much higher molecular weights than their bacterial counterparts. A thiaminase I of the single-celled amoeboflagellate Naegleria gruberi is the only eukaryotic thiaminase I to have been cloned, sequenced, and expressed. Here, we present the crystal structure of N. gruberi thiaminase I to a resolution of 2.8 Å, solved by isomorphous replacement and pseudo-two-wavelength multiwavelength anomalous diffraction and refined to an R factor of 0.231 (Rfree, 0.265). This structure was used to solve the structure of the enzyme in complex with 3-deazathiamin, a noncleavable thiamin analog and enzyme inhibitor (2.7 Å; R, 0.233; Rfree, 0.267). These structures define the mode of thiamin binding to this class of thiaminases and indicate the involvement of Asp272 as the catalytic base. This enzyme is able to use thiamin as a substrate and is active with amines such as aniline and veratrylamine as well as sulfhydryl compounds such as l-cysteine and β-mercaptoethanol as cosubstrates. Despite significant differences in polypeptide sequence and length, we have shown that the N. gruberi thiaminase I is homologous in structure and activity to a previously characterized bacterial thiaminase I.
Beam divergence angle distribution dependence on data pattern (2004)

Data patterns are shown to affect the far field distribution of vertical cavity surface emitting lasers (VCSELs). Two data patterns with different frequency content resulted in different beam profile distributions even though both patterns had 50% duty cycles resulting in the same thermal dissipation. The effect of gain switching and varying high and low drive levels was also investigated. Angle dependent waveforms displayed overshoot on axis and undershoot off axis. The potential impact of pattern dependent launch conditions is discussed.
Steady-State Heat Conduction Design Sensitivity Analysis of Mold by 3-D BEM. (1993)

In injection molds and compression molds, slender cooling channels or heating pipes are used to control the temperature over the cavity surfaces of the molds. The optimum design of layout and size of such slender channels is important for high-quality production and reduction of the forming cycle time of products. In this paper, a boundary element approach for design sensitivity analysis of cooling or heating of such molds is presented. The boundary integral equation for steady-state heat conduction problems implemented with a special type of pipe elements is first differentiated with respect to an arbitrary design parameter, and a boundary integral equation relating the temperatures and heat fluxes to their sensitivity coefficients is derived. The effectiveness of the system developed based on the above formulation is illustrated through some numerical test examples.
Proteomics ofXenopusdevelopment (2015)

Modern mass spectrometry-based methods provide an exciting opportunity to characterize protein expression in the developing embryo. We have employed an isotopic labeling technology to quantify the expression dynamics of nearly 6000 proteins across six stages of development in Xenopus laevis from the single stage zygote through the mid-blastula transition and the onset of organogenesis. Approximately 40% of the proteins show significant changes in expression across the development stages. The expression changes for these proteins naturally falls into six clusters corresponding to major events that mark early Xenopus development. A subset of experiments in this study have quantified protein expression differences between single embryos at the same stage of development, showing that, within experimental error, embryos at the same developmental stage have identical protein expression levels.
BlyncSync: Enabling Multimodal Smartwatch Gestures with Synchronous Touch and Blink (2020)

Input techniques have been drawing abiding attention along with the continual miniaturization of personal computers. In this paper, we present BlyncSync, a novel multi-modal gesture set that leverages the synchronicity of touch and blink events to augment the input vocabulary of smartwatches with a rapid gesture, while at the same time, offers a solution to the false activation problem of blink-based input. BlyncSync contributes the concept of a mutual delimiter, where two modalities are used to jointly delimit the intention of each other's input. A study shows that BlyncSync is 33% faster than using a baseline input delimiter (physical smartwatch button), with only 150ms in overhead cost compared to traditional touch events. Furthermore, our data indicates that the gesture can be tuned to elicit a true positive rate of 97% and a false positive rate of 1.68%.
Fermi resonance in the overtone spectra of the CH chromophore in tribromomethane. 2. Visible spectra (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFermi resonance in the overtone spectra of the CH chromophore in tribromomethane. 2. Visible spectraJan Davidsson, Jonathan H. Gutow, Richard N. Zare, Hans A. Hollenstein, Roberto R. Marquardt, and Martin QuackCite this: J. Phys. Chem. 1991, 95, 3, 1201–1209Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://pubs.acs.org/doi/10.1021/j100156a031https://doi.org/10.1021/j100156a031research-articleACS PublicationsRequest reuse permissionsArticle Views159Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Downlink with partially cooperating base stations (2010)

For a downlink scenario with two base stations and one receiving mobile, where the base stations are connected by a noiseless finite-capacity backbone, we determine the optimal cooperation and coding strategy. The performance is not influenced by the degree of channel state information at the mobile, but it increases with increasing channel state information at the base stations. If the link capacities exceed finite thresholds, the system achieves full-cooperation performance. The optimal cooperation protocol is a simple one-shot strategy.
IMPACT OF LARGE CHANGES IN MINUTE VENTILATION ON END TIDAL CO2 DURING CONTROLLED LOW CARDIAC OUTPUT IN SWINE (1993)

Falk, Jay L; Idris, A; DelDuca, K; O'Brien, D; Melker, R; Rush, W; Staples, E Author Information
Selective N3‐ and 5′‐O‐Alkylation of 2′,3′‐O‐isopropylideneuridine with methyl iodide (1997)

Abstract The 2′,3′‐ O ‐isopropylideneuridine ( 1 ) reacts with MeI in the presence of an excess of NaH in THF giving 2′,3′‐ O ‐isopropylidene‐5′‐ O ‐methyluridine ( 2 ). Prolonged reaction time gives rise to 2′,3′‐ O ‐isopropylidene‐3,5′‐ O ‐dimethyluridine ( 4 ). The use of an equimolar amount of base and alkylating agent results predominantly in methylation at N(3) (→ 3).
Density-based particle fractionation (2014)

We present a label-free method capable of rapidly sorting particles based on their densities. Our device relies on deterministic lateral displacement (DLD) and achieves density fractionation by the use of T-shaped posts. By combining it with a lateral density gradient we achieve a density separation that is independent of size within a range given by the device geometry. Herein we present a proof-of-principle method which, in comparison to traditional density-separation techniques, is suitable for lab-on-a-chip environment.