gebhart/patrepeval huggingface dataset:
Size-to-Charge Dispersion of Collision-Induced Dissociation Product Ions for Enhancement of Structural Information and Product Ion Identification (2014)

Ion mobility is used to disperse product ions formed by collision-induced dissociation (CID) on the basis of charge state and size-to-charge ratio. We previously described an approach for combining CID with ion mobility mass spectrometry (IM-MS) for dispersing fragment ions along charge state specific trend lines (Zinnel, N. F.; Pai, P. J.; Russell, D. H. Anal. Chem. 2012, 84, 3390; Sowell, R. A.; Koeniger, S. L.; Valentine, S. J.; Moon, M. H.; Clemmer, D. E. J. Am. Soc. Mass Spectrom. 2004, 15, 1341; McLean, J. A.; Ruotolo, B. T.; Gillig, K. J.; Russell, D. H. Int. J. Mass Spectrom. 2005, 240, 301), and this approach was used to assign metal ion binding sites for human metallothionein protein MT-2a (Chen, S. H.; Russell, W. K.; Russell, D. H. Anal. Chem. 2013, 85, 3229). Here, we use this approach to distinguish b-type N-terminal fragment ions from both internal fragment ions and y-type C-terminal fragment ions. We also show that in some cases specific secondary structural elements, viz., extended coils or helices, can be obtained for the y-type fragment ions series. The advantage of this approach is that product ion identity can be correlated to gas-phase ion structure, which provides rapid identification of the onset and termination of extended coil structure in peptides.
Methods to eliminate dynamic errors in high-performance SAR A/D converter (2008)

The DNL performance of the last generation of Analog-to-Digital Converter (A/D Converter, ADC) based on the principle of SAR (successive-approximation register) was limited by a small amount of spikes at particular codes that changed with varying conversion rate, so that these errors were called 'dynamic errors'. These errors always appeared in pairs: a long code followed by a short code at very particular transitions. This paper is discussing the root source and techniques that fix the problem. These techniques were implemented and verified on silicon.
Design of the Optimal Feed System for High Power Microwave Antenna System (2006)

In this paper, the optimal feed system which is located between source and reflector antenna is suggested for the miniaturization of high power microwave (HPM) antenna system. The suggested feed system is fabricated in order to examine and measured radiation patterns that agree with the calculated patterns are obtained. As a result, this feed system has high gain about 27 dBi. Return loss is less than -23 dB at 10 GHz and the -25 dB beamwidth of the radiation pattern equals to 29deg in H-plane
Computer assisted identification of metabolite mass spectra: How can quantum mechanics help? (2016)

info:eu-repo/semantics/nonPublished
An EM-Based Approach for Mining Word Senses from Corpora (2007)

Manually collecting contexts of a target word and grouping them based on their meanings yields a set of word senses but the task is quite tedious. Towards automated lexicography, this paper proposes a word-sense discrimination method based on two modern techniques; EM algorithm and principal component analysis (PCA). The spherical Gaussian EM algorithm enhanced with PCA for robust initialization is proposed to cluster word senses of a target word automatically. Three variants of the algorithm, namely PCA, sGEM, and PCA-sGEM, are investigated using a gold standard dataset of two polysemous words. The clustering result is evaluated using the measures of purity and entropy as well as a more recent measure called normalized mutual information (NMI). The experimental result indicates that the proposed algorithms gain promising performance with regard to discriminate word senses and the PCA-sGEM outperforms the other two methods to some extent.
High speed and high power performances of LTG-GaAs based TWPDs in telecommunication wavelength (∼1.3 μm) (2003)

Summary form only given. We demonstrate ultra-high speed and high saturation power performance of LTG-GaAs based MSM traveling-wave photodetectors (TWPDs) in the telecommunication wavelength regime (/spl sim/1300 nm). Due to the short carrier trapping time of the LTG-GaAs layer and the superior microwave guiding structure in MSM TWPDs, record ultra-high peak power bandwidth product performance has been obtained in long absorption length devices. These results suggest applications in low-cost GaAs based photo-receiver circuits without electrical pre-amplifiers and high power photomixer devices which are compatible with fiber optical communication components.
Effect of losartan on performance and physiological responses to exercise at high altitude (5035 m) (2021)

Losartan had no observable effect on resting or exercising BP, exercise-induced symptomology of pulmonary hypertension or performance at 5035 m.
Highly Efficient Red Phosphorescent OLEDs based on Non‐Conjugated Silicon‐Cored Spirobifluorene Derivative Doped with Ir‐Complexes (2009)

Abstract A novel host material containing silicon‐cored spirobifluorene derivative (SBP‐TS‐PSB), is designed, synthesized, and characterized for red phosphorescent organic light‐emitting diodes (OLEDs). The SBP‐TS‐PSB has excellent thermal and morphological stabilities and exhibits high electroluminescence (EL) efficiency as a host for the red phosphorescent OLEDs. The electrophosphorescence properties of the devices using SBP‐TS‐PSB as the host and red phosphorescent iridium (III) complexes as the emitter are investigated and these devices exhibit higher EL performances compared with the reference devices with 4,4′‐ N , N ′‐dicarbazole‐biphenyl (CBP) as a host material; for example, a (piq) 2 Ir(acac)‐doped SBP‐TS‐PSB device shows maximum external quantum efficiency of η ext = 14.6%, power efficiency of 10.3 lm W −1 and Commission International de L'Eclairage color coordinates (0.68, 0.32) at J = 1.5 mA cm −2 , while the device with the CBP host shows maximum η ext = 12.1%. These high performances can be mainly explained by efficient triplet energy transfer from the host to the guests and improved charge balance attributable to the bipolar characteristics of the spirobifluorene group.
Editorial Commentary: A New Star Is Born—The Knotless All‐Suture Anchor (2020)

The development of all-suture anchors has revolutionized the field of orthopaedic surgery. Biomechanically, these anchors have similar or better strength when compared with conventional solid anchors. All-suture anchors allow the suture to be placed in cortical bone tunnels, with a smaller diameter, thus limiting potential iatrogenic damage. To avoid the inconsistencies of knot tying and eliminate knot stacks, knotless all-suture anchors have been increasingly used in arthroscopic surgery. This may reduce the potential risk of knot abrasion, which can lead to soft-tissue or cartilage damage. Depending on the intraoperative situation and surgeon preference, surgeons must decide whether knotted or knotless anchor systems are indicated.
A glimpse on biological activities of tellurium compounds (2009)

Tellurium is a rare element which has been regarded as a toxic, non-essential trace element and its biological role is not clearly established to date. Besides of that, the biological effects of elemental tellurium and some of its inorganic and organic derivatives have been studied, leading to a set of interesting and promising applications. As an example, it can be highlighted the uses of alkali-metal tellurites and tellurates in microbiology, the antioxidant effects of organotellurides and diorganoditellurides and the immunomodulatory effects of the non-toxic inorganic tellurane, named AS-101, and the plethora of its uses. Inasmuch, the nascent applications of organic telluranes (organotelluranes) as protease inhibitors and its applications in disease models are the most recent contribution to the scenario of the biological effects and applications of tellurium and its compounds discussed in this manuscript.
Laser transformation hardening of Ti–6Al–4V in solid state with accompanying kinetic model (2007)

Laser transformation hardening in the solid state is shown to successfully provide a surface hardness increase of almost 40% for Ti–6Al–4V with a case depth over 2.5 mm while reducing surface damage. This was completed by testing a matrix of four conditions using a direct diode laser, varying the power and the travel speed, followed by a mechanical and microstructural analysis of the hardness development. A kinetic model was developed to predict these changes by explaining the amount of α that transforms to β upon heating and the fraction of martensitic α′ that forms with natural quenching. The model matched the experimental results reasonably well with the major separation due to the poor hardenability of Ti–6Al–4V.
MicroPlay (2012)

Smartphones are an ideal platform for local multiplayer games, thanks to their computational and networking capabilities as well as their popularity and portability. However, existing game engines do not exploit the locality of players to improve game latency. In this paper, we propose MicroPlay, a complete networking framework for local multiplayer mobile games. To the best of our knowledge, this is the first framework that exploits local connections between smartphones, and in particular, the broadcast nature of the wireless medium, to provide smooth, accurate rendering of all players with two desired properties. First, it performs direct-input rendering (i.e., without any inter- or extrapolation of game state) for all players; second, it provides very low game latency. We implement a MicroPlay prototype on Android phones, as well as an example multiplayer car racing game, called Racer, in order to demonstrate MicroPlay's capabilities. Our experiments show that cars can be rendered smoothly, without any prediction of state, and with only 20-30 ms game latency.
A prospective analysis evaluating tissue biopsy location and its clinical relevance in chronic rhinosinusitis with nasal polyps (2017)

Although ECP in NP was higher than in UT tissue, eosinophilia in UT tissue was a more clinically coherent biomarker of baseline radiographic severity, comorbid asthma and AERD, and prospective polyp recurrence risk than NP eosinophilia.
FOKUS II — Space Flight of a Vacuum Compatible Dual Frequency Comb System (2019)

Since its invention in the late 1990s, the frequency comb technology revolutionized the world of optical frequency metrology [1] and is now widely available as of-the-shelf product around the globe. While promising use cases for space-based applications exist, the space technology readiness, particularly regarding miniaturization and ruggedness, remains an obstacle for its deployment. In April 2015 and January 2016 the first frequency comb system FOKUS I was launched into space on a TEXUS sounding rocket, demonstrating the robustness and reliability of the technology [2].
The Role of Impact Modifier Particle Size and Adhesion on the Toughness of PET (2000)

PET was made supertough by melt blending with 20 weight percent of a reactive terpolymer (ethylene - methyl acrylate - glycidyl methacrylate). Supertoughness was obtained using both amorphous and semicrystalline PET matrices. Two distinct toughening mechanisms were identified: massive shear yielding in the matrix when the dispersed particle size was less than 200 nanometers, and multiple crazing in the matrix when the particle size was larger. Samples that contained only 10% of the reactive terpolymer, or a non-reactive copolymer, were brittle. Interparticle distance alone was insufficient to explain these results. Instead, the improved toughness could be explained using a cavitation model.
CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPLEXED WITH EM139 (2018)

Human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the biosynthesis of the most potent natural estrogen 17β-estradiol (E2) from estrone (E1) in the ovary and peripheral tissues, playing a pivotal role in the progression of estrogen-dependent diseases. N-n-Butyl-N-methyl-ll-(16'α-chloro-3',17'β-dihydroxyestra-1',3',5'(10')-trien-7'α-yl)undecanamide (EM-139) was previously described as a dual-site inhibitor that can inhibit 17β-HSD1 transforming E1 into E2 and also inhibit estrogen receptor. In the present report, we describe the co-crystallization of EM-139 with 17β-HSD1 as well as the analysis of the three-dimensional structure of the enzyme/inhibitor complex. The crystal is grown under similar condition as native crystals, whereas the space group is changed to I121 never observed in other 17β-HSD1 crystals before. The steroidal moiety of the bound EM-139 molecule has shown a binding pattern similar to E2 in the E2 binary complex. The O-3 of the inhibitor develops hydrogen bonds with residues His221 and Glu282, whereas the O-17 makes hydrogen bonds with Ser142 and Tyr155. The bulky 7α-alkyl moiety of the inhibitor, which is essential for its anti-estrogenic activity but cannot be defined in the electron density, may compromise the inhibitory effect of EM-139 to 17β-HSD1. Moreover, the 16α-Cl atom shows no obvious interaction with surrounding residues. The atomic level understanding of the inhibitory mechanism of EM-139 provides important information for the inhibitor design of 17β-HSD1, which will facilitate future development of more potent and selective inhibitors of the enzyme for therapeutic purposes.
Orbicularis Oculi Myo-osseous Fixation: A New Treatment for Benign Essential Blepharospasm and Blepharospasm Associated With Diffuse Facial Dystonia (Meige Syndrome) (2010)

Initial data suggest that this procedure appears safe, well tolerated, and useful in the treatment of patients with essential blepharospasm and Meige syndrome responding poorly to botulinum toxin therapy.
Supplementary Figure Legend from Targeting TRAIL Death Receptor 4 with Trivalent DR4 Atrimer Complexes (2023)

&lt;p&gt;PDF file, 55K.&lt;/p&gt;
Clonal Analysis of Insulin and Somatostatin Secretionand L-Dopa Decarboxylase Expression by a Rat Islet Cell Tumor* (1983)

A cell line, RIN-m, established from a transplantable rat islet cell tumor secretes insulin (IRI) and somatostatin (SRIF) and expresses high levels of the key amine precursor uptake and decarboxylation (APUD) cell enzyme L-dopa-decarboxylase (DDC). Conditioned medium from a rat pituitary tumor line GH3, secreting GH and PRL, improved the cloning efficiency of RIN-m cells 24-fold and enabled the isolation and establishment of a large number of primary and secondary clones. These clones were used to study clonal relationships between peptide hormone secretion and APUD features of an endocrine cell. All the primary and secondary clonal derivatives, irrespective of whether they secreted peptide hormones, maintained high levels of DDC activity. In contrast, IRI and SRIF secretion patterns of the primary clones were highly variable. Selective recloning of primary clones resulted in the isolation of subclones which produced either no hormones or high levels of either IRI or SRIF, but no clone that continuously secreted high levels of both IRI and SRIF. We conclude that: 1) the rat pituitary tumor line GH3 produces a factor(s), possibly GH and/or PRL, which dramatically affects the growth and cloning efficiency of rat islet tumor cells; 2) in contrast to the variability in hormone secretion patterns, DDC activity was consistently expressed in all clones and subclones; and 3) although wide fluctuation in hormone secretion levels occurred among the primary clones, subclones were obtained which revealed that IRI and SRIF can be expressed independently. The subclones of RIN-m developed should be useful for the analyses of factors influencing the synthesis, storage, and secretion of IRI and SRIF. The persistence of high DDC activity in the primary and secondary clones suggests that the APUD property of this endocrine cell may be a primitive differentiation feature closely related to the stem cell; in contrast, peptide hormone production may be associated with more terminal differentiation events.
Direct vision in minimally invasive epicardial procedures: preliminary tests of prototype instrumentation (2015)

This study investigated the use of direct visualization to enhance minimally invasive epicardial procedures. A commercially available miniature camera was placed in a prototype subxiphoid introducer needle and bench top, in vitro and in vivo tests of system performance were made during simulated and actual attempts at pericardial access and cardio-endoscopy. This system had an unshielded field of view of 100° and a resolution of 220 × 224 pixels. When a sleeve used to maintain depth of field was slid past the distal tip of the camera probe, the field of view would decrease by ≈15° per millimetre of sleeve extension, but without loss of image quality. While tests during in vivo subxiphoid access in a porcine model revealed that the pericardial membrane was difficult to localize, the results also showed excellent resolution of the coronary arteries on the epicardial surface. These findings and potential improvements are discussed in detail.
Total Inpatient Morphine Milligram Equivalents Can Predict Long-term Opioid Use After Transforaminal Lumbar Interbody Fusion (2019)

3.
Modulation of Enhancer Looping and Differential Gene Targeting by Epstein-Barr Virus Transcription Factors Directs Cellular Reprogramming (2013)

Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes deregulated by specific combinations of these EBNAs through unknown mechanisms. Comparing human genome binding by these viral transcription factors, we discovered that 25% of binding sites were shared by EBNA 2 and the EBNA 3s and were located predominantly in enhancers. Moreover, 80% of potential EBNA 3A, 3B or 3C target genes were also targeted by EBNA 2, implicating extensive interplay between EBNA 2 and 3 proteins in cellular reprogramming. Investigating shared enhancer sites neighbouring two new targets (WEE1 and CTBP2) we discovered that EBNA 3 proteins repress transcription by modulating enhancer-promoter loop formation to establish repressive chromatin hubs or prevent assembly of active hubs. Re-ChIP analysis revealed that EBNA 2 and 3 proteins do not bind simultaneously at shared sites but compete for binding thereby modulating enhancer-promoter interactions. At an EBNA 3-only intergenic enhancer site between ADAM28 and ADAMDEC1 EBNA 3C was also able to independently direct epigenetic repression of both genes through enhancer-promoter looping. Significantly, studying shared or unique EBNA 3 binding sites at WEE1, CTBP2, ITGAL (LFA-1 alpha chain), BCL2L11 (Bim) and the ADAMs, we also discovered that different sets of EBNA 3 proteins bind regulatory elements in a gene and cell-type specific manner. Binding profiles correlated with the effects of individual EBNA 3 proteins on the expression of these genes, providing a molecular basis for the targeting of different sets of cellular genes by the EBNA 3s. Our results therefore highlight the influence of the genomic and cellular context in determining the specificity of gene deregulation by EBV and provide a paradigm for host-cell reprogramming through modulation of enhancer-promoter interactions by viral transcription factors.
Magnetic perturbation and associated energies of the antiphase boundaries in ordered Ni3Al (2010)

The anisotropy of antiphase boundary (APB) energies in ordered L12–Ni3Al is studied, owing to its importance in understanding the anomalous flow behavior of this intermetallic compound. We report first-principle calculations for two types of APBs in the ordered compound: (001) and (111). The magnetic perturbations associated with these APBs are calculated as a function of supercell size to ensure that their periodic images are isolated both magnetically and elastically. The magnetic perturbation associated with the (111) APB is wider than that of the (001) APB. The fully relaxed, spin-polarized APB energies for (001) and (111) APBs are calculated to be 82 mJ/m2 and 177 mJ/m2, respectively. The resulting anisotropy ratio of σ(111)/σ(001)=2.16, which is significantly higher than previously reported values, suggests that cross-slip between (001) and (111) is highly favorable.
Fast Amide Couplings in Water: Extraction, Column Chromatography, and Crystallization Not Required (2020)

In the micelle of PS-750-M, the presence of 3° amides from the surfactant proline linker mimics dimethylformamide, dimethylacetamide, and <i>N</i>-methyl-2-pyrrolidone. The resultant micellar properties enable extremely fast amide couplings mediated by 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide (without hydroxybenzotriazole), rather than expensive and specialized coupling agents. Conditions have been developed wherein products precipitate, and isolation by filtration completely avoids the use of organic solvent. This methodology is scalable and avoids product epimerization.
Dreaming during Covid-19 pandemic: Computational assessment of dreams reveals mental suffering and fear of contagion (2020)

Neuroscience and psychology agree that dreaming helps to cope with negative emotions and learn from experience. The current global threat related to the COVID-19 pandemic led to widespread social isolation. Does dreaming change and/or reflect mental suffering? To address these questions, we applied natural language processing tools to study 239 dream reports from 67 individuals either before the Covid-19 outbreak or during March-April, 2020, when quarantine was imposed in Brazil following the pandemic announcement by the WHO. Pandemic dreams showed a higher proportion of anger and sadness words and higher average semantic similarities to the terms contamination and cleanness. These features were associated with mental suffering related to social isolation, as they explained 39% of the variance in PANSS negative subscale (p=0.0092). These results corroborate the hypothesis that pandemic dreams reflect mental suffering, fear of contagion, and important changes in daily habits.
Regulation of spindle pole body assembly and cytokinesis by the centrin-binding protein Sfi1 in fission yeast (2014)

Centrosomes play critical roles in the cell division cycle and ciliogenesis. Sfi1 is a centrin-binding protein conserved from yeast to humans. Budding yeast Sfi1 is essential for the initiation of spindle pole body (SPB; yeast centrosome) duplication. However, the recruitment and partitioning of Sfi1 to centrosomal structures have never been fully investigated in any organism, and the presumed importance of the conserved tryptophans in the internal repeats of Sfi1 remains untested. Here we report that in fission yeast, instead of doubling abruptly at the initiation of SPB duplication and remaining at a constant level thereafter, Sfi1 is gradually recruited to SPBs throughout the cell cycle. Like an sfi1Δ mutant, a Trp-to-Arg mutant (sfi1-M46) forms monopolar spindles and exhibits mitosis and cytokinesis defects. Sfi1-M46 protein associates preferentially with one of the two daughter SPBs during mitosis, resulting in a failure of new SPB assembly in the SPB receiving insufficient Sfi1. Although all five conserved tryptophans tested are involved in Sfi1 partitioning, the importance of the individual repeats in Sfi1 differs. In summary, our results reveal a link between the conserved tryptophans and Sfi1 partitioning and suggest a revision of the model for SPB assembly.
Session 27 overview: Image sensors (2013)

Lists the sessions held at the conference proceedings.