gebhart/patrepeval huggingface dataset:
Study of PD behaviors on a crossed sample of magnet-wire with repetitive bipolar impulses for inverter-fed motor coil insulation (2005)

PD behavior with repetitive bipolar impulse has been investigated on "crossed sample" of magnet wires in comparison with a conventional twisted-pair sample. The crossed sample is suitable for optical PD observation, surface potential distribution measurement and SEM observation during or after PD test without loosening wires. Fluctuations of PDIV and PD charge were reconfirmed on it as reported on twisted-pair. The averaged values of PDIV and PD charge in each condition are consistent considering the size effect, since the crossed sample has contact length of c.a. one hundreds of that of twisted-pair sample. Surface potential distribution near the crossing point showed the direct evidence of charge-assisted discharge model. SEM observation suggests that surface erosion was not found after the saturation of PDIV, which suggests the trend of fluctuation may be due to surface properties change.
Multidentate 18F-Polypegylated Styrylpyridines As Imaging Agents for Aβ Plaques in Cerebral Amyloid Angiopathy (CAA) (2011)

β-Amyloid plaques (Aβ plaques) in the brain are associated with cerebral amyloid angiopathy (CAA). Imaging agents that could target the Aβ plaques in the living human brain would be potentially valuable as biomarkers in patients with CAA. A new series of (18)F styrylpyridine derivatives with high molecular weights for selectively targeting Aβ plaques in the blood vessels of the brain but excluded from the brain parenchyma is reported. The styrylpyridine derivatives, 8a-c, display high binding affinities and specificity to Aβ plaques (K(i) = 2.87, 3.24, and 7.71 nM, respectively). In vitro autoradiography of [(18)F]8a shows labeling of β-amyloid plaques associated with blood vessel walls in human brain sections of subjects with CAA and also in the tissue of AD brain sections. The results suggest that [(18)F]8a may be a useful PET imaging agent for selectively detecting Aβ plaques associated with cerebral vessels in the living human brain.
Platelet-Specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury (2016)

Platelets and neutrophils contribute to the development of acute lung injury (ALI). However, the mechanism by which platelets make this contribution is incompletely understood. We investigated whether the two most abundant platelet chemokines, CXCL7, which induces neutrophil chemotaxis and activation, and CXCL4, which does neither, mediate ALI through complementary pathogenic pathways. To examine the role of platelet-derived chemokines in the pathogenesis of ALI using Cxcl7<sup>-/-</sup> and Cxcl4<sup>-/-</sup> knockout mice and mice that express human CXCL7 or CXCL4, we measured levels of chemokines in these mice. ALI was then induced by acid aspiration, and the severity of injury was evaluated by histology and by the presence of neutrophils and protein in the bronchoalveolar lavage fluid. Pulmonary vascular permeability was studied in vivo by measuring extravasation of fluorescently labeled dextran. Murine CXCL7, both recombinant and native protein released from platelets, can be N-terminally processed by cathepsin G to yield a biologically active CXCL7 fragment. Although Cxcl7<sup>-/-</sup> mice are protected from lung injury through the preservation of endothelial/epithelial barrier function combined with impaired neutrophils transmigration, Cxcl4<sup>-/-</sup> mice are protected through improved barrier function without affecting neutrophils transmigration to the airways. Sensitivity to ALI is restored by transgenic expression of CXCL7 or CXCL4. Platelet-derived CXCL7 and CXCL4 contribute to the pathogenesis of ALI through complementary effects on neutrophil chemotaxis and through activation and vascular permeability.
Wafer level microarcing model in 90nm chemical-vapor deposition low-k via etch on 300mm silicon-on-insulator substrate (2006)

In SiOCH (C-doped SiO2) via etch application, high polymer deposition chemistry is needed for better selectivity to both photoresist and underlying barrier materials. To prevent etch stop, high ion energy plasma is required to achieve a good process window. C4F6∕CH3F, etc., was used as via main etch chemistry for better selectivity and striation performance. However, wafer level microarcing (WLMA) was observed at the wafer edge around the guard ring. This WLMA phenomenon is different from that of the magnetically enhanced reactive ion etching or capacitively coupled plasma low-gap reactor. By process optimization, we managed to develop a process that is production-ramp worthy. We have also compared the rf parameters during via etch process on both silicon-on-insulator and bulk Si substrates, which shows no significant difference. The electrical and defect scan results suggest that it is free from WLMA.
Modeling, Simulation and Control of Turboelectric Propulsion Systems for More Electric Aircrafts using Modelica (2022)

View Video Presentation: https://doi.org/10.2514/6.2022-3873.vid As aviation industry moves towards More Electric Aircraft technologies, electrification of non-propulsive loads is becoming more common. Moreover, new designs for electrified propulsive systems have been proposed in the literature, drawing attention from the aviation sector. Amidst the proposed topologies, turboelectric architectures present a set of benefits, becoming attractive for more electric powertrains. Given this context, this paper presents Modelica as the means for developing models to assess the dynamic performance for the different possible turboelectric architectures that can be adopted by industry in the next few years. Individual components have their mathematical models presented along with their respective Modelica implementation. Two different possible architectures are assembled using the Modelica models and their dynamic performances over a 400-second sample flight mission are assessed. The dynamic simulations provide insights for choosing system’s parameters, controllers’ design and system sizing.
Multiview Glasses-Free 3-D Laparoscopy (2012)

Numerous attempts have been made to introduce three-dimensional (3-D) video systems into clinical routine, particularly for surgeries. The drawback with all of them thus far has been the fact that they require users to wear cumbersome glasses in order to receive the advantage of stereoscopy. In this study, we present, to our best knowledge, the world's very first laparoscopic surgical system that delivers glasses-free multiview 3-D in high-definition (HD) resolution. In addition to quantitative evaluations of the individual video processing components in our previous studies, we perform an initial subjective study with laparoscopically experienced surgeons, yielding very promising results. This study is still preliminary and requires further evaluation before the system may be introduced into standard surgical routine. Yet, we have developed a fully functioning prototype and successfully demonstrated its potential to numerous surgeons.
Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor (2023)

The comprehensive characterization of the receptive range of TAS2R2 allows the classification into the group of TAS2Rs with a medium number of bitter agonists. The variability of bitter taste and its potential influences on food choice in some human populations may be even higher than assumed.
A new species of Casmaria H. Adams & A. Adams, 1853 (Gastropoda, Cassidae) from the Philippines identified by molecular data (2014)

The genus Casmaria H. Adams &amp; A. Adams, 1853 (family Cassidae) is widespread in the tropical Indo-Pacific and has been documented from some Atlantic localities as well. Two Casmaria species, C. erinaceus (Linnaeus, 1758) and C. ponderosa (Gmelin, 1791), are common in Indo-Pacific shallow-water sandy bottom communities and are characterized by high morphological variability; both species encompass multiple, often sympatric forms of uncertain status. In the present study we carry out a phylogenetic analysis of some Philippine Casmaria morphs and demonstrate that one of the distinctive morphs earlier assigned to Casmaria ponderosa is in fact a different species, which we describe as Casmaria boblehmani sp. nov. The smooth form of Casmaria ponderosa, C. ponderosa ponderosa, and the solid nodulose form, widely called “form nodulosa” despite being strikingly different in shell morphology, are shown to be conspecific. Studied specimens of these two morphs even from different localities share the same haplotype of the CO1 gene. In light of these new data on the morphological variability of Casmaria species, we discuss criteria of species delimitation in the genus Casmaria and possible affinities of Casmaria boblehmani sp. nov. within the genus.
Proteome Analysis of Condensed Barley Mitotic Chromosomes (2021)

Proteins play a major role in the three-dimensional organization of nuclear genome and its function. While histones arrange DNA into a nucleosome fiber, other proteins contribute to higher-order chromatin structures in interphase nuclei, and mitotic/meiotic chromosomes. Despite the key role of proteins in maintaining genome integrity and transferring hereditary information to daughter cells and progenies, the knowledge about their function remains fragmentary. This is particularly true for the proteins of condensed chromosomes and, in particular, chromosomes of plants. Here, we purified barley mitotic metaphase chromosomes by a flow cytometric sorting and characterized their proteins. Peptides from tryptic protein digests were fractionated either on a cation exchanger or reversed-phase microgradient system before liquid chromatography coupled to tandem mass spectrometry. Chromosomal proteins comprising almost 900 identifications were classified based on a combination of software prediction, available database localization information, sequence homology, and domain representation. A biological context evaluation indicated the presence of several groups of abundant proteins including histones, topoisomerase 2, POLYMERASE 2, condensin subunits, and many proteins with chromatin-related functions. Proteins involved in processes related to DNA replication, transcription, and repair as well as nucleolar proteins were found. We have experimentally validated the presence of FIBRILLARIN 1, one of the nucleolar proteins, on metaphase chromosomes, suggesting that plant chromosomes are coated with proteins during mitosis, similar to those of human and animals. These results improve significantly the knowledge of plant chromosomal proteins and provide a basis for their functional characterization and comparative phylogenetic analyses.
Three Xanthones from Poeciloneuron pauciflorum and Mammea acuminata. (1998)

Abstract From the stem of Poeciloneuron pauciflorum , two new xanthones (1,6-dihydroxy-7-methoxyxanthone and 1,6-dihydroxy-7-methoxyxanthone 6-O-β- d -glucoside ) in addition to 12 known compounds (1,5-dihydroxy-, 1,5-dihydroxy-3-methoxy-, 1,7-dihydroxy-, 1-hydroxy-7-methoxy-, 2-methoxy-, 4-methoxy-, 1,4,5-trihydroxy-, 1,3,5-trihydroxy-, 1,3,6-trihydroxy-7-methoxy-, 1,3,7-trihydroxy-, 3-hydroxy-2-methoxyxanthone and (−)-epicatechin) were isolated. From the aerial parts (stems and bark) of Mammea acuminata , a new xanthone (2,7-dihydroxyxanthone) was isolated in addition to two known xanthones (1,5-dihydroxy- and 5-hydroxy-1-methoxyxanthone) and (−)-epicatechin. The structures were established by spectral analysis and total synthesis in case of 1,6-dihydroxy-7-methoxyxanthone.
SiC MOSFET design considerations for reliable high voltage operation (2017)

SiC MOSFETs have demonstrated continued performance improvement and maturation in the areas of Gate oxide stability and reliability over the past years. While necessary, this alone is not sufficient to achieve reliable high voltage operation. In this paper, the design constraints impacting high voltage reliability and their impact on SiC MOSFET performance at useful operating conditions are discussed. Experimental results are demonstrated with industry benchmark, reliable operation of up to T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">j</sub> =200°C with 1.2kV/25mOhm SiC MOSFETs and T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">j</sub> =175°C, 1.7kV/450A all-SiC MOSFET Dual-Switch modules. Avalanche ruggedness of the high-performance devices is also demonstrated with single-pulse energy densities of 9-15J/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> recorded with Drain currents as high as ID= 90A for 0.2cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> die.
Herpes simplex virus type 2–specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I alleles (2002)

Clonally expressed T-cell receptor alphabeta heterodimers are able to bind many different major histocompatibility complex/peptide combinations. This promiscuity is thought to be required for adequate surveillance against microbial and malignancy-associated antigens. After transplantation, T cells may react with nonself structures, contributing to graft-versus-host disease, in the case of hematopoietic stem cell transplantation, or graft failure, when the host immune system is preserved. We describe 2 distinct HLA A*0201-restricted, cytotoxic CD8 T-cell responses to the prevalent chronic pathogen, herpes simplex virus type 2, that cross-react with cells bearing specific alleles of the common HLA B44 family. Transfection of human or primate renal epithelial cells with HLA class I complementary DNA confirmed these results. Given the prevalence of this viral infection and the HLA alleles involved, it is possible that this cross-reactivity may be involved in clinically significant events.
Supplementary Figures and Legends from Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene–Driven Myeloid Leukemia (2023)

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High-Gain Parametric Amplification On-Chip at Low Pump Powers (2023)

We demonstrate a novel amplification scheme that yields high (30-dB), continuous-wave parametric amplification of weak signals using small-footprint microresonators at pump power levels (&lt; 10 mW) compatible with typical chip-scale lasers.
Room-temperature single photon emitters in cubic boron nitride nanocrystals (2020)

Color centers in wide bandgap semiconductors are attracting broad attention for use as platforms for quantum technologies relying on room-temperature single-photon emission (SPE), and for nanoscale metrology applications building on the centers’ response to electric and magnetic fields. Here, we demonstrate room-temperature SPE from defects in cubic boron nitride (cBN) nanocrystals, which we unambiguously assign to the cubic phase using spectrally resolved Raman imaging. These isolated spots show photoluminescence (PL) spectra with zero-phonon lines (ZPLs) within the visible region (496–700 nm) when subject to sub-bandgap laser excitation. Second-order autocorrelation of the emitted photons reveals antibunching with g 2 (0) ∼ 0.2, and a decay constant of 2.75 ns that is further confirmed through fluorescence lifetime measurements. The results presented herein prove the existence of optically addressable isolated quantum emitters originating from defects in cBN, making this material an interesting platform for opto-electronic devices and quantum applications.
A Batch System with Efficient Adaptive Scheduling for Malleable and Evolving Applications (2015)

The throughput of supercomputers depends not only on efficient job scheduling but also on the type of jobs that form the workload. Malleable jobs are most favourable for a cluster as they can dynamically adapt to a changing allocation of resources. The batch system can expand or shrink a running malleable job to improve system utilization, throughput, and response times. In the past, however, the rigid nature of commonly used programming models like MPI made writing malleable applications a daunting task, which is why it remained largely unrealized. This is now changing. To improve fault tolerance, load imbalance, and energy efficiency in emerging exactable systems, more adaptive programming paradigms such as Charm++ enter the scene. Although they offer better support for malleability, current batch systems still lack management facilities for malleable jobs and are therefore incapable of leveraging their potential. In this paper, we present an extension of the Torque/Maui batch system for malleability. We propose a novel malleable job scheduling strategy and show the first batch system capable of efficiently managing rigid, malleable, and evolving jobs together. We demonstrate that our strategy achieves consistently superior performance in comparison to every other state-of-the-art malleable job scheduling strategy under varying dynamics of the workload.
The head leads the body: a curvature-based kinematic description of C. elegans (2012)

Caenorhabditis elegans, a free-living soil nematode, propels itself by producing undulatory body motion and displays a rich variety of body shapes and trajectories during its locomotion in complex environments. Here we show that the complex shapes and trajectories of C. elegans have a simple analytical description in curvature representation. Our model is based on the assumption that the curvature wave is generated in the head segment of the worm body and propagates backwards. We have found that a simple harmonic function for the curvature can capture multiple worm shapes during the undulatory movement. The worm body trajectories can be well represented in terms of piecewise sinusoidal curvature with abrupt changes in amplitude, wavevector, and phase.
A set of specific miRNAs is connected with murine and human gastric cancer (2012)

MircoRNAs as a new class of regulatory molecules have been investigated in many specific cells and organs in healthy and diseased conditions. Although miRNA signatures can be directly assessed in patients' affected tissues such as tumor sections, recent studies revealed that miRNA profiles can also be obtained indirectly, that is, from the patients' peripheral blood. For better understanding of miRNA's contribution to gastric carcinoma (one of the leading causes of cancer-related mortality worldwide), we screened for deregulated miRNAs in blood collected from human cancer patients and compared the expression patterns with a gastric carcinoma mouse model (Tff1 knock-out). The profiles were assessed using species-specific miRNA microarrays. Among many dozens of deregulated miRNAs (219 in H. sapiens; 75 in M. musculus), a subset of eight miRNAs comparable in sequence from both species was noted. By in silico analysis, their involvement in targeting neoplastic and MAPkinase pathways was demonstrated. We found a high probability of linkage of all noted miRNAs to pathways in cancer with P-values of 0.013 and 0.018 in mice and humans, respectively. Linkage to the MAPK-signaling pathway in mice was observed with a P-value of 0.01. Moreover, when comparing the 219 deregulated miRNAs obtained from blood with deregulated miRNAs derived from gastric cancer (GC) tissues, as published previously, 24 miRNAs were identical. If confirmed in a larger patient pool, these miRNAs could constitute appropriate blood-born biomarkers for GC.
Modeling and Simulation in Clinical Pharmacology and Dose Finding (2013)

The breakout session 2 of the European Medicines Agency/European Federation of Pharmaceutical Industries and Associations Modeling and Simulation (M&S) workshop focused on two topics: when and how M&S should be used and would be accepted by the authorities for the dose-regimen selection; and when and how M&S can be applied to register a dosing regimen without the need for a specific study. Each topic was introduced by an industry and regulatory perspective, followed by case examples for illustration (Table 1).CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e29; doi:10.1038/psp.2013.5; advance online publication 27 February 2013.
Perspective—A Guideline for Reporting Performance Metrics with Electrochemical Capacitors: From Electrode Materials to Full Devices (2017)

International audience
The double-edged effects of annealing MgO underlayers on the efficient synthesis of single-wall carbon nanotube forests (2017)

Recently, the millimetre-scale, highly efficient synthesis of single-wall carbon nanotube (SWCNT) forests from Fe catalysts has been reported through the annealing of the magnesia (MgO) underlayer. Here, we report the double-edged effects of underlayer annealing on the efficiency and structure of the SWCNT forest synthesis through a temperature-dependent examination. Our results showed that the efficiency of the SWCNT forests sharply increased with increased underlayer annealing temperatures from 600 °C up to 900 °C due to a temperature-dependent structural modification, characterized by increased grain size and reduced defects, of the MgO underlayer. Beyond this temperature, the SWCNT fraction also decreased as a result of further structural modification of the MgO underlayer. This exemplifies the double-edged effects of annealing. Specifically, for underlayer annealing below 600 °C, the catalyst subsurface diffusion was found to limit the growth efficiency, and for excessively high underlayer annealing temperatures (>900 °C), catalyst coalescence/ripening led to the formation of double-wall carbon nanotubes. As a result, three distinct regions of synthesis were observed: (i) a "low yield" region below a threshold temperature (∼600 °C); (ii) an "increased yield" region from 600 to 900 °C, and (iii) a "saturation" region above 900 °C. The efficient SWCNT forest synthesis could only occur within a specific annealing temperature window as a result of this double-edged effects of underlayer annealing.
Extraction of a Thermodynamic Property for Biochemical Reactions in the Metabolic Pathway (2003)

When metabolic reconstruction is performed to elucidate the biological function of a complete genome, the path computation between two compounds is sometimes necessary. For example, if a missing enzyme is found in a biosynthesis pathway for a compound that is supposed to be synthesized, we need to search an alternative enzyme or a path for the enzyme reaction. Typically, the input of the path computation is a set of two compounds that correspond to a substrate and a product, and the output is a set of all possible paths that connect the two compounds. However, this set includes many paths that are not working in actual biological pathways. Previously we have considered the standard Gibbs free energy changes in enzyme reactions and discussed about their applicability to the path computation [1]. In this work, we computed the standard Gibbs free energies of the compounds and the standard Gibbs free energy changes of the reactions registered in the LIGAND database [2]. We covered as many entries as possible with the advent of the automatic compound structure comparison method [3]. We also developed a new function to sort the result of path computation in consideration of the standard Gibbs free energy changes of the pathway. We report here a new addition to the pathway computation tool in the KEGG system and discuss about the distribution of the standard Gibbs free energy changes in the metabolic pathways for further evaluation.
Modular Multilevel Converter Modelling, Control and Analysis under Grid Frequency Deviations (2012)

A tool for component sizing for MMCs has been developed and tested through simulations in PLECS. The steady-state behaviour under grid frequency deviations - interesting for offshore wind farm connections - has been analysed, providing insights in MMC characteristics and further testing the proposed tool.