gebhart/patrepeval huggingface dataset:
The Polyphenol Fisetin Protects Bone by Repressing NF-κB and MKP-1-Dependent Signaling Pathways in Osteoclasts (2013)

Osteoporosis is a bone pathology leading to increase fractures risk and challenging quality of life. Since current treatments could exhibit deleterious side effects, the use of food compounds derived from plants represents a promising innovative alternative due to their potential therapeutic and preventive activities against human diseases. In this study, we investigated the ability of the polyphenol fisetin to counter osteoporosis and analyzed the cellular and molecular mechanisms involved. In vivo, fisetin consumption significantly prevented bone loss in estrogen deficiency and inflammation mice osteoporosis models. Indeed, bone mineral density, micro-architecture parameters and bone markers were positively modulated by fisetin. Consistent with in vivo results, we showed that fisetin represses RANKL-induced osteoclast differentiation and activity as demonstrated by an inhibition of multinucleated cells formation, TRAP activity and differentiation genes expression. The signaling pathways NF-κB, p38 MAPK, JNK and the key transcription factors c-Fos and NFATc1 expressions induced by RANKL, were negatively regulated by fisetin. We further showed that fisetin inhibits the constitutive proteasomal degradation of MKP-1, the phosphatase that deactivates p38 and JNK. Consistently, using shRNA stable cell lines, we demonstrated that impairment of MKP-1 decreases fisetin potency. Taken together, these results strongly support that fisetin should be further considered as a bone protective agent.
CO2 EOR and Storage in Heavy Oil Reservoirs Underlying Permafrost (2012)

Injection of the captured CO2 from industrial sources in oil reservoirs can alleviate negative environmental impacts of CO2 emission into the atmosphere and at the same time provides economic rationale for CCS by improving oil recovery. Compared to light oil, heavy oils have a much larger carbon footprint and hence, from environmental point of view, are more attractive targets for CCS. Heavy oil reservoirs are usually produced by thermal recovery techniques which only exacerbates adverse environmental effects of oil production from these reservoirs. Heavy oil reservoirs can therefore be good candidates for combining CCS and EOR. Examples of such reservoirs are found on North Slope, Alaska, where huge heavy oil resources exist in shallow reservoirs at exceptionally low reservoir temperature because of permafrost. This paper presents the results of a series of coreflood studies using a heavy crude sample from a permafrost region. The experiments compare CO2 storage capacity of the rock sample at reservoir conditions under different injection strategies and determine the additional recovery as a result of CO2 injection. The results show that CO2 injection doubled the heavy oil recovery by plain waterflood however the storage capacity of the rock was not significantly affected by the injection strategy.
SpeckleCam: High-resolution Computational Speckle Contrast Tomography for Deep Blood Flow Imaging (2023)

Laser speckle contrast imaging is widely used in clinical studies to monitor blood flow distribution. Speckle contrast tomography, similar to diffuse optical tomography, extends speckle contrast imaging to provide deep tissue blood flow information. However, the current speckle contrast tomography techniques suffer from poor spatial resolution and involve both computation and memory intensive reconstruction algorithms. In this work, we present SpeckleCam, a camera-based system to reconstruct high resolution 3D blood flow distribution deep inside the skin. Our approach replaces the traditional forward model using diffuse approximations with Monte-Carlo simulations-based convolutional forward model, which enables us to develop an improved deep tissue blood flow reconstruction algorithm. We show that our proposed approach can recover complex structures up to 6 mm deep inside a tissue-like scattering medium in the reflection geometry. We also conduct human experiments to demonstrate that our approach can detect reduced flow in major blood vessels during vascular occlusion.
Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer (2022)

A patient with progressive metastatic pancreatic cancer was treated with a single infusion of 16.2×10<sup>9</sup> autologous T cells that had been genetically engineered to clonally express two allogeneic HLA-C*08:02-restricted T-cell receptors (TCRs) targeting mutant KRAS G12D expressed by the tumors. The patient had regression of visceral metastases (overall partial response of 72% according to the Response Evaluation Criteria in Solid Tumors, version 1.1); the response was ongoing at 6 months. The engineered T cells constituted more than 2% of all the circulating peripheral-blood T cells 6 months after the cell transfer. In this patient, TCR gene therapy targeting the KRAS G12D driver mutation mediated the objective regression of metastatic pancreatic cancer. (Funded by the Providence Portland Medical Foundation.).
Summarization of 3D Video by Rate-Distortion Trade-off (2007)

3D video, which consists of a sequence of mesh models, can reproduce dynamic scenes containing 3D information. To summarize 3D video, a key frame extraction method is developed using rate-distortion (R-D) trade-off. For this purpose, an effective feature vector is extracted for each frame. Shot detection is performed using the feature vectors as a preprocessing followed by key frame extraction. Simple but reasonable definitions of rate and distortion are presented. Based on an assumption of linearity, an R-D curve is generated in each shot, where the locations of the key frames are optimized. Finally, R-D trade-off can be achieved by optimizing a cost function using a Lagrange multiplier, where the number of key frames is optimized in each shot. Therefore, our system will automatically determine the best locations and the number of key frames in the sense of R-D trade-off. Our experimental results show the extracted key frames are compact and faithful to the original 3D video.
Multi-rate (111-Gb/s, 2×43-Gb/s, and 8×10.7-Gb/s) transmission at 50-GHz channel spacing over 1040-km field-deployed fiber (2008)

111-Gb/s transmission combined with 2times43-Gb/s and 8times10.7-Gb/s on a 50-GHz grid over 1,040-km field fiber and two ROADMs is demonstrated, showing the feasibility of 100 G overlaying existing 10 G/40 G commercial systems.
Room Temperature Synthesis and Crystal Structure of mer‐[MoBr3Py3], the Vibrational Spectra of mer‐[MoBr3Py3], mer‐[MoI3Py3] and trans,trans‐[MoBr2Py4][MoBr4Py2] (2013)

Abstract The reaction of MoBr 3 and pyridine at room temperature provided single crystals of mer ‐[MoX 3 Py 3 ]. mer ‐[MoBr 3 Py 3 ] crystallizes in P 2 1 / n monoclinic space group with cell dimensions a = 9.2297(5) Å, b = 12.911(8) Å, c = 15.7022(9) Å and β = 90.479(3)°. There are four formula units in a unit cell. Mo–N distances are in the range 2.196(8)–2.214(8) Å and Mo–Br distances are 2.573(1) Å and 2.574(1) Å. Fundamental vibrational frequencies of pyridine molecules are strongly affected upon coordination in all three coordination compounds: mer ‐[MoBr 3 Py 3 ], mer ‐[MoI 3 Py 3 ] and trans , trans ‐[MoBr 2 Py 4 ][MoBr 4 Py 2 ].
Synthesis and Structural Characterization of Highly Fluorinated Sulfimides and Sulfoximides as Functional Building Blocks for Materials Science (2005)

Abstract Several examples of highly fluorinated sulfimides and sulfoximides have been synthesized in order to assess their potential usefulness as functional materials, such as liquid crystals or as active components in molecular electronics. The polarity of liquid crystals with these types of functional groups was lower than expected, due to conformational effects. A new synthetic method provides a convenient access to N , S , S ‐triaryl sulfimides and sulfoximides, which were characterized by X‐ray crystallography. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2005)
GPS and UWB for indoor navigation (2001)

10 0 C/A-code spectrum A multitude of applications would benefit from precise indoor navigation. Anywhere from automating storage in warehouses to tracking firemen in hazardous environments would make such an endeavor worthwhile. Some server-based GPS systems, like SnapTrack, already claim some navigation capabilities indoors. However, such systems are in general accurate to within a few tens of meters. Furthermore, pseudolites have been deployed for indoor use. Although some experimental setups show decent navigation performance, there is a question of whether GPS has a “good enough ” signal structure for such applications in the first place. Spread spectrum pseudoranging is susceptible to multipath that is less than one chip width away from a direct path ray. In the case of GPS C/A-code, the chip length is about 300 m. Obviously, most indoor signal reflection delays would be significantly shorter than that distance. Ultra-WideBand (UWB) technology is built around transmitting short discrete pulses instead of continuously modulating a code onto a carrier signal. Such pulses typically last only 1-2 ns, and one can distinguish pulses that are more than 1-2 ft apart. Thus, making UWB systems robust to multipath delays of more than one pulse width. We measured the impulse response of the RF channel at the Stanford University LAAS Laboratory. This paper quantifies that multipath channel in terms of average delay and delay spread. We found several cases where multipath components were stronger in magnitude than the direct signal. Whereas such an environment would bias pseudorange measurements of GPS C/A-code, a properly designed UWB system could resolve most multipath and accuracy would degrade more gracefully than for GPS.
Performance Analysis and Code Design for Cooperative Relay Channels (2006)

We treat the LDPC code design for relay channels in this paper. The capacity of relay channels has been analyzed in current literature. How to approach such capacity with the aid of good codes is, however, a challenging problem. An efficient structure is proposed to decouple the factor graph (FG) of a B-block transmission into successive partial FGs, and then, the code design can be performed over the partial FG. Based on this efficient structure, we develop the approaches to find the optimum code ensemble. In particular, we formulate the relay and the destination operations as virtual multiple-antenna channels. Moreover, we develop the approaches based on the binary symmetric channel modelling for the relay and Gaussian approximation to fast estimate the extrinsic mutual information of the destination detector output. Then we can analyze the performance of the relay system using the EXIT technique. Differential evolution is employed to search for the optimum code ensemble. Extensive simulations are further carried out to show the results of the proposed optimum code design.
Amplification of 26-fs, 2-TW pulses near the gain-narrowing limit in Ti:sapphire (1995)

We report the generation of 26-fs-duration pulses, with an energy of 60 mJ, from a simple multipass Ti:sapphire amplifier system. The peak power of our amplified pulses is 2 TW, and the repetition rate is 10 Hz. Our amplifier design consists of two highly doped multipass amplifiers and is simple and compact. We use an all-reflective, low-groove-density grating stretcher and compressor, combined with a relatively short material path length in the amplifier. This design allows us to minimize higher-order dispersion. The result is a laser system that generates multiterrawatt transform-limited pulses, with good beam quality and low amplified-spontaneous-emission levels, at a duration near the theoretical limit imposed by gain narrowing in Ti:sapphire.
CHAOTIC MEAN FIELD DYNAMICS OF A BOOLEAN NETWORK WITH RANDOM CONNECTIVITY (2007)

Random Boolean networks have been used as simple models of gene regulatory networks, enabling the study of the dynamic behavior of complex biological systems. However, analytical treatment has been difficult because of the structural heterogeneity and the vast state space of these networks. Here we used mean field approximations to analyze the dynamics of a class of Boolean networks in which nodes have random degree (connectivity) distributions, characterized by the mean degree k and variance D. To achieve this we generalized the simple cellular automata rule 126 and used it as the Boolean function for all nodes. The equation for the evolution of the density of the network state is presented as a one-dimensional map for various input degree distributions, with k and D as the control parameters. The mean field dynamics is compared with the data obtained from the simulations of the Boolean network. Bifurcation diagrams and Lyapunov exponents for different parameter values were computed for the map, showing period doubling route to chaos with increasing k. Onset of chaos was delayed (occurred at higher k) with the increase in variance D of the connectivity. Thus, the network tends to be less chaotic when the heterogeneity, as measured by the variance of connectivity, was higher.
Polymer lenses with antireflection structures prepared using anodic porous alumina molds (2016)

In this study, a nanoimprinting process was used with anodic porous alumina as a mold to fabricate polymer lenses with antireflection structures. The antireflection structures were composed of a tapered pillar array, which served to suppress the reflectance of incident light of visible wavelengths. It was also demonstrated that polymer lenses with a tapered hole array on their surface could be obtained by injection molding using a Ni mold prepared through electroforming by depositing Ni with anodic porous alumina as a template. The polymer lenses with antireflection structures demonstrated in this study should be applicable for various types of functional optical devices, such as cameras, optical microscopes, etc.
Computation migration (1993)

We describe computation migration , a new technique that is based on compile-time program transformations, for accesing remote data in a distributed-memory parallel system. In contrast with RPC-style access, where the access is performed remotely, and with data migration, where the data is moved so that it is local, computation migration moves part of the current thread to the processor where the data resides. The access is performed at the remote processor, and the migrated thread portion continues to run on that same processor; this makes subsequent accesses in the thread portion local. We describe an implementation of computation migration that consists of two parts: an implementation that migrates single activation frames, and a high-level language annotation that allows a programmer to express when migration is desired. We performed experiments using two applications; these experiments demonstrate that computation migration is a valuable alternative to RPC and data migration.
“Through My Dream”: Trevor Joyce’s Translations (2010)

Almost all Irish translators work with what Lawrence Venuti calls a “domesticating” model of recreating a translated poem as if it had been originally written in the target language. However, some of the most important Irish translators of the past, notably James Clarence Mangan and Brian Coffey, have used what Venuti terms a “foreignizing” strategy which, on the contrary, highlights the difficulties and resistances of the source text to transparent re-presentation. The two approaches roughly correspond to two modes of translation evident in the work of the most influential anglophone poetry translator of the early twentieth century, Ezra Pound. In his translation of the Buile Suibhne as the Poems of Sweeny Peregrine (1976), which cites Poundian precedent, the contemporary Irish neo-modernist poet Trevor Joyce (b. 1947) uses both modes to produce a destabilised, postmodern “working” which exploits the original’s gaps, scribal interpolations and narrative contradictions, as well as poignantly rendering its expressivist lyrics. Radical translation strategies can be seen to inform other aspects of Joyce’s work, from his use of Japanese and Chinese forms and materials in Stone Floods (1995), to cut-up and collage in Trem Neul (2000), and from folk-song and poetry from the Finno-Ugric, Hungarian and Irish in What’s in Store (2007) and Courts of Air and Earth (2008) to, most recently, the unpublished Rome’s Wreck, which “translates” Edmund Spenser’s “The Ruines of Rome” (1591) “intralingually”, to use Roman Jakobson’s term, that is, from one form of English into another.
Création et manipulation de scènes sonores pour la wave field synthesis (2004)

La Wave Field Synthesis (WFS) est une technique de reproduction sonore permettant de dépasser les limites des systèmes conventionnels. La zone de reproduction optimale peut ainsi s'étendre à toute la pièce de reproduction par l'utilisation de bancs de haut-parleur disposés tout autour de la salle. Ces bancs de haut-parleurs constituent autant de «fenêtres» vers un espace acoustique extérieur. La WFS s'appuie sur une décomposition de type objet de la scène sonore (codage par le «contenu», ensemble de sources interagissant avec un espace acoustique) et permet la reproduction de sources sonores virtuelles (hologrammes sonores). Un auditeur se promenant dans une installation sonore WFS subit ainsi les variations de localisation naturelles liées à la disposition des sources virtuelles. Cette technique permet d'autre part la reproduction d'un effet salle réaliste dont la perception reste cohérente lors des déplacements de l'auditeur. Cette technique a été l'un des aspects majeurs étudiés lors du projet européen Carrouso (IST 1999-20993, janvier 2001-juin 2003] qui a permis de développer ou d'améliorer les technologies liées à l'enregistrement, la transmission et la reproduction, en WFS, de scènes sonores codées au format Mpeg-4 (format de codage par le contenu). Après une introduction sur les origines et les bases de la WFS, cet article présente ces technologies ainsi que les techniques de production et de mixage de scènes sonores développées au cours et à la suite du projet Carrouso.
ChemInform Abstract: Decatromicins A and B, New Antibiotics Produced by Actinomadura sp. MK73‐NF4. Part 2. Structure Determination. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Immune Activations and Viral Tissue Compartmentalization During Progressive HIV-1 Infection of Humanized Mice (2019)

Human immunodeficiency virus type one (HIV-1) tissue compartments are established soon after viral infection. However, the timing in which virus gains a permanent foothold in tissue and the cellular factors that control early viral-immune events are incompletely understood. These are critical events in studies of HIV-1 pathogenesis and in the development of viral reservoirs after antiretroviral therapy. Moreover, factors affecting the permanence of viral-tissue interactions underlie barriers designed to eliminate HIV-1 infection. To this end we investigated the temporal and spatial viral and host factors during HIV-1 seeding of tissue compartments. Two humanized NOD.Cg-Prkdc<sup>scid</sup> IL2rg<sup>tm1Wjl</sup>/SzJ mouse models were employed. In the first, immune deficient mice were reconstituted with human CD34+ cord blood hematopoietic stem cells (HSC) (hu-HSC) and in the second mice were transplanted with adult mature human peripheral lymphocytes (hu-PBL). Both, in measure, reflect relationships between immune activation and viral infection as seen in an infected human host. Following humanization both mice models were infected with HIV-1<sub>ADA</sub> at 10<sup>4</sup> 50% tissue culture infective doses. Viral nucleic acids and protein and immune cell profiles were assayed in brain, lung, spleen, liver, kidney, lymph nodes, bone marrow, and gut from 3 to 42 days. Peripheral CD4+ T cell loss began at 3 days together with detection of HIV-1 RNA in both mouse models after initiation of HIV-1 infection. HIV-1 was observed in all tested tissues at days 3 and 14 in hu- PBL and HSC mice, respectively. Immune impairment was most prominent in hu-PBL mice. T cell maturation and inflammation factors were linked directly to viral tissue seeding in both mouse models. We conclude that early viral tissue compartmentalization provides a roadmap for investigations into HIV-1 elimination.
Effect of Moisture Adsorption on the Electrical Properties of Hardened Portland Cement Compacts (1995)

Dense bodies were formed by cold compaction of Portland cement, with and without silica fume additions, followed by autoclaving at temperatures up to 240°C. Samples were analyzed to determine crystalline phases and pore structures in the cementitious matrix, and their electrical properties (resistivity and complex permittivity) measured. The adsorption of moisture was monitored as a function of relative humidity and correlated to changes in electrical properties. These changes can be explained in terms of the formation of conducting paths as water is adsorbed into the connected pore system.
Idiotypic repertoire of anti-hen eggwhite lysozyme antibodies probed with hybridomas. Selection after immunization of an IdX marker common to antibodies of distinct epitope specificity. (1981)

A panel of hybridoma antibodies obtained from lymphoid cells that were fused during a primary response ("early") or a secondary response ("late") gave results concordant with analysis of conventional, in vivo-produced anti-lysozyme idiotypes: early antibodies did not display the predominant anti-hen eggwhite lysozyme idiotype (IdX-HEL), whereas late antibodies all displayed IdX-HEL. Furthermore, individual late hybridomas could each remove the entire anti-IdX-HEL activity by absorption, whereas early hybridomas could not. The epitope specificities of the hybridomas in both the early and late populations were heterogenous. We conclude that epitypic specificity in the response to HEL is determined independently from idiotypic specificity and that the predominant idiotype is selected for during the maturation of the anti-lysozyme response.
X-band TM/sub 01/-TE/sub 11/ mode converter (2004)

This paper presents a direct TM/sub 01/-TE/sub 11/ small mode converter using a circular waveguide with tilted structure for X-band high power microwave system. It is designed to transmit microwave energy from a relativistic backward-wave oscillator (RBWO) source to horn antenna effectively, with optimized geometry through a parameter study. The simulated and measured results of return loss, fractional power of each mode, impedance bandwidth, and mode pattern are provided.
Supplementary Figure 2 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC (2023)

&lt;p&gt;Supplementary Figure 2 - PDF file 111K, CO-1686 inhibits cell growth in EGFR-mutant erlotinib-resistant cell lines&lt;/p&gt;