gebhart/patrepeval huggingface dataset:
The Photochemistry of 4,5-Carbomethoxy-1,2,3-thiadiazole: Direct Observation of Thiirene Formation and Its Decay in Solution (2013)

The photochemistry of 4,5-carbomethoxy-1,2,3-thiadiazole in solution was studied at room temperature with use of UV-vis and IR transient absorption spectroscopies (λ(ex) = 266 nm). Ultrafast time-resolved techniques demonstrate that there is a very fast rise (<0.4 ps) of bis(carbomethoxy)thiirene in acetonitrile, and that it is the only intermediate formed. The lifetime of the thiirene is limited by dimerization to eventually form tetra(carbomethoxy)thiophene.
Expression of Concern: Practical Issues in Implementing Analog-to-Information Converters (2006)

The stability and programmability of digital signal processing systems has motivated engineers to move the analog-to-digital conversion (ADC) process closer and closer to the front end of many signal processing systems in order to perform as much processing as possible in the digital domain. Unfortunately, many important applications, including radar and communication systems, involve wideband signals that seriously stress modern ADCs; sampling these signals above the Nyquist rate is in some cases challenging and in others impossible. While wideband signals by definition have a large bandwidth, often the amount of information they carry per second is much lower; that is, they are compressible in some sense. The first contribution of this paper is a new framework for wideband signal acquisition purpose-built for compressible signals that enables sub-Nyquist data acquisition via an analog-to-information converter (AIC). The framework is based on the recently developed theory of compressive sensing in which a small number of non-adaptive, randomized measurements are sufficient to reconstruct compressible signals. The second contribution of this paper is an AIC implementation design and study of the tradeoffs and non-idealities introduced by real hardware. The goal is to identify and optimize the parameters that dominate the overall system performance
Two distinct protein isoforms are encoded by ntk, a csk-related tyrosine protein kinase gene. (1994)

Recently, we and others have cloned cDNAs encoding a second member of the Csk family of inhibitory tyrosine protein kinases, which we have termed Ntk. Intriguingly, the mouse ntk cDNA sequences published by two independent groups differed by the presence or absence of a 136 nucleotide-insert near their 5' ends. In this report, we demonstrate that this 136 nucleotide-sequence likely corresponds to a complete exon in the ntk gene (termed exon 2), and that the two types of cDNAs/transcripts are produced by alternative splicing. Using ribonuclease protection assays, it was also established that brain and lymphoid organs, as well as most hemopoietic cells, predominantly expressed ntk transcripts lacking exon 2. In contrast, selected hemopoietic cell lines, such as the immature myeloid cell lines 32D cl3(G) and WEHI-3B, exclusively possessed exon 2-bearing RNAs. Interestingly, exon 2 introduced a novel in-frame upstream AUG in the ntk transcript, which is in the appropriate context for translation initiation. Evidence was obtained that this AUG is utilized in vivo, and that it extends the amino-terminal sequence of Ntk by 40 amino acids. Indeed, while exon 2-deficient ntk RNAs were translated into a 52 kilodalton (kDa) polypeptide (p52ntk), those bearing exon 2 produced a 56 kDa protein (p56ntk). Furthermore, p56ntk, but not p52ntk, was recognized by an antiserum directed against the novel amino-terminal sequence encoded by exon 2. Additional biochemical characterizations showed that p52ntk and p56ntk were localized to the cytoplasm, and that they partially accumulated in the detergent-insoluble cellular fraction. This last finding suggested that the Ntk proteins can associate with the cytoskeleton. Finally, through linkage analysis of two multilocus crosses, the ntk gene was mapped to Chromosome 10 in the mouse. Taken together, these data showed that ntk, a csk-related tyrosine protein kinase gene, encodes two protein isoforms expressed in distinct cell types. Moreover, they raised the possibility that Ntk may be involved in the regulation of Src-like enzymes in detergent-insoluble cellular compartments.
Ocular and systemic responses to water soluble material derived from Cannabis sativa (marihuana) (1981)

A water soluble material, isolated from Cannabis sativa, has been tested in albino and pigmented rabbits and rhesus monkeys for both ocular and systemic effects. Intravenous administration produced a dose-related fall in intraocular pressure in both albino and pigmented rabbits with concentrations as low as 0.005 mg/animal being effective, but no response was found in monkeys. High concentrations (0.2 to 1 mg/animal) induced a hypertensive phase in intraocular pressure prior to the ocular hypotension; higher concentrations (2 or 5 mg/animal) also induced antidiuresis and general relaxation. Tachyphylaxis was found to repeated daily injections. Alpha and beta-adrenergic antagonists caused some reduction of the hypertensive phase but had no effect on the hypotensive phase. Superior cervical ganglionectomy did not influence the time course of the intraocular pressure response. Indomethacin inhibited the hypertensive intraocular pressure phase but was ineffective against the hypotensive phase. Systemic blood pressure was unchanged following intravenous administration of 0.2 mg material/animal. Aqueous tumor protein concentration was increased at both 1 and 6 hours after intravenous administration, becoming greater at the later time. Aqueous humor turnover rate was substantially reduced reaching a minimum 8.75 hours after administration. Topical administration was ineffective in eyes when the epithelium was removed in rabbits with and without pretreatment with aspirin. Neither gastric nor suppository administration of large quantities (10 mg or greater) of material had any influence on intraocular pressure.
Infrared Perfect Absorbers Fabricated by Colloidal Mask Etching of Al–Al2O3–Al Trilayers (2015)

We propose a combined fabrication method of reactive ion etching and large-scale colloidal mask to fabricate mid-infrared metamaterial perfect absorbers using aluminum–aluminum oxide-aluminum trilayers. The absorptivities of the fabricated samples reached as high as 98% and the absorption bandwidths were comparable to those of the absorbers based on gold or silver. Following Kirchhoff’s law, their emission spectra exhibited sharp single emission peaks indicating high potential as narrow-band infrared emitters. The results obtained here demonstrate that earth-abundant aluminum is a high-performance plasmonic materials in the mid-infrared range, and open up a route for fabricating cost-effective scalable plasmonic devices such as efficient light harvesting structures, thermal emitters, and infrared sensors.
Toward Multimedia Applications on the STARNET WDM Network (1995)

Technological progress and increased user needs have provided the primary impetus for development of high-speed networks which simultaneously deliver real-time services in addition to standard file and data transfer services. Real-time services must provide not only bandwidth, but must also limit latency in order to meet quality of service requirements. Typical real-time services include compressed voice and video.
A Comprehensive Review of Male Reproductive Toxic Effects of Aflatoxin (2011)

Aflatoxins, highly oxygenated, heterocyclic, difuranocoumarin compounds that could be present in human foods and animal feedstuffs, are an important group of mycotoxins produced by the fungi Aspergillus flavus, A. parasiticus and A. nomius (Diaz et al., 2008). Other species of Aspergillus such as A. bombycis, A. ochraceoroseus and A. pseudotamari may also produce aflatoxins (Bennett & Klich, 2003; On a worldwide scale, the aflatoxins are found in stored food commodities and oil seeds such as corn, peanuts, cottonseed, rice, wheat, oats, barley, sorghum, millet, sweet potatoes, potatoes, sesame, cacao beans, almonds, etc., which on consumption pose health hazards to animals, including aquaculture species of fish, and humans Health effects occur in fish, companion animals, livestock, poultry and humans because aflatoxins are potent hepatotoxins, immunosuppressants, mutagens, carcinogens and teratogens. Public health concerns center on both primary poisoning from aflatoxins in commodities, food and feedstuffs, and relay poisoning from aflatoxins in milk There are four major natural aflatoxins (AFs), AFB1, AFB2, AFG1 and AFG2. The hierarchy of toxicity of different aflatoxins is in the order AFB1>AFG1>AFB2>AFG2. There are two additional metabolic products of aflatoxins B1 and B2, viz., M1 and M2. More than 5 billion people in developing countries worldwide are at risk of chronic exposure to naturally occurring aflatoxins through contaminated foods Symptoms of aflatoxicosis include feed refusal, decreased feed efficiency, stunted growth, decreased milk production and impaired reproductive efficiency
Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing (2016)

The use of inorganic nanoparticles (NPs) for biosensing requires that they exhibit high colloidal stability under various physiological conditions. Here, we report on a general approach to render hydrophobic NPs into hydrophilic ones that are ready for bioconjugation. The method uses peglyated polymers conjugated with multiple dopamines, which results in multidentate coordination. As proof-of-concept, we applied the coating to stabilize ferrite and lanthanide NPs synthesized by thermal decomposition. Both polymer-coated NPs showed excellent water solubility and were stable at high salt concentrations under physiological conditions. We used these NPs as molecular-sensing agents to detect exosomes and bacterial nucleic acids.
Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside (2021)

Filariae are vector-borne nematodes responsible for an enormous burden of disease. Human lymphatic filariasis, caused by Wuchereria bancrofti, Brugia malayi, and Brugia timori, and onchocerciasis (caused by Onchocerca volvulus) are neglected parasitic diseases of major public health significance in tropical regions. To date, therapeutic efforts to eliminate human filariasis have been hampered by the lack of a drug with sufficient macrofilaricidal and/or long-term sterilizing effects that is suitable for use in mass drug administration (MDA) programs, particularly in areas co-endemic with Loa loa, the causative agent of loiasis. Emodepside, a semi-synthetic cyclooctadepsipeptide, has been shown to have broad-spectrum efficacy against gastrointestinal nematodes in a variety of mammalian hosts, and has been approved as an active ingredient in dewormers for cats and dogs. This paper evaluates, compares (where appropriate) and summarizes the in vitro effects of emodepside against a range of filarial nematodes at various developmental stages. Emodepside inhibited the motility of all tested stages of filariae frequently used as surrogate species for preclinical investigations (Acanthocheilonema viteae, Brugia pahangi, Litomosoides sigmodontis, Onchocerca gutturosa, and Onchocerca lienalis), human-pathogenic filariae (B. malayi) and filariae of veterinary importance (Dirofilaria immitis) in a concentration-dependent manner. While motility of all filariae was inhibited, both stage- and species-specific differences were observed. However, whether these differences were detected because of stage- and/or species-specific factors or as a consequence of variations in protocol parameters among the participating laboratories (such as purification of the parasites, read-out units, composition of media, incubation conditions, duration of incubation etc.) remains unclear. This study, however, clearly shows that emodepside demonstrates broad-spectrum in vitro activity against filarial nematode species across different genera and can therefore be validated as a promising candidate for the treatment of human filariases, including onchocerciasis and lymphatic filariasis.
Prediction of Total Organic Carbon in Organic-Rich Shale Rocks Using Thermal Neutron Parameters (2023)

Total organic carbon (TOC) content is one of the crucial parameters that determine the value of the source rock. The TOC content gives important indications about the source rocks and hydrocarbon volume. Various techniques have been utilized for TOC quantification, either by geochemical analysis of source rocks in laboratories or using well logs to develop mathematical correlations and advanced machine learning models. Laboratory methods require intense sampling intervals to have an accurate understanding of the reservoir, and depending on the thickness of the interested formation, it can be time-consuming and costly. Empirical correlations based on well logs (e.g., density, sonic, gamma ray, and resistivity) showed fast predictions and very reasonable accuracies. However, other important parameters such as thermal neutron logs have not been studied yet as a potential input for providing reliable TOC predictions. Also, different studies estimate the TOC based on the well-logging data for various formations; however, limited studies were reported to predict the TOC for the Horn River Formation. Therefore, the objective of this study is to estimate the TOC variations based on the thermal neutron logs using one of the largest source rocks in Canada: The Horn River Formation. More than 150 data sets were collected and used in this work. The parameters of the artificial neural network (ANN) model were fine-tuned in order to improve the model's prediction performance. Furthermore, an empirical correlation was developed utilizing the optimized ANN model to allow fast and direct application for the developed model. The developed correlation can predict the TOC with an average absolute error of 0.52 wt %. The proposed TOC model was able to outperform the previous models, and the coefficient of determination was increased from 0.28 to 0.73. Overall, the proposed TOC model can provide high accuracy for TOC ranges from 0.3 to 6.44 wt %. The developed model can provide a real-time quantification for the organic matter maturity, helping to allocate the zones of mature organic matter within the drilled formations.
MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation (2015)

Myocyte enhancer factor 2B (MEF2B) is a transcription factor with mutation hotspots at K4, Y69 and D83 in diffuse large B-cell lymphoma (DLBCL). To provide insight into the regulatory network of MEF2B, in this study, we analyse global gene expression and DNA-binding patterns. We find that candidate MEF2B direct target genes include RHOB, RHOD, CDH13, ITGA5 and CAV1, and that indirect target genes of MEF2B include MYC, TGFB1, CARD11, MEF2C, NDRG1 and FN1. MEF2B overexpression increases HEK293A cell migration and epithelial-mesenchymal transition, and decreases DLBCL cell chemotaxis. K4E, Y69H and D83V MEF2B mutations decrease the capacity of MEF2B to activate transcription and decrease its' effects on cell migration. The K4E and D83V mutations decrease MEF2B DNA binding. In conclusion, our map of the MEF2B regulome connects MEF2B to drivers of oncogenesis.
Natural Convection in an Annulus with Two Rotating Boundaries (1990)

This paper is concerned with developing natural convection in an open-ended vertical annulus with two rotating boundaries and a uniformly heated inner wall. The governing equations have been numerically solved; the obtained results show the effect of a rotating outer boundary on the developing tangential, axial and radial velocity profiles and the pressure distribution across the annular gap. Also, results are presented to clarify the effect of the outer cylinder rotation on the temperatures of the two walls and the relationship between the annulus height and the volumetric flow rate. For the special case of a stationary outer cylinder, the development of the tangential boundary layer displacement thickness in an annulus of radius ratio 0.9 is given, so that Astill's stability criterion can be utilized.
Germ‐line and rearranged Tcrd transcription distinguish bona fide NK cells and NK‐like γδ T cells (2007)

NK cells and gammadelta T cells are distinct subsets of lymphocytes that contextually share multiple phenotypic and functional characteristics. However, the acquisition and the extent of these similarities remain poorly understood. Here, using T cell receptor delta locus-histone 2B-enhanced GFP (Tcrd-H2BEGFP) reporter mice, we show that germ-line transcription of Tcrd occurs in all maturing NK cells. We also describe a population of mouse NK-like cells that are indistinguishable from "bona fide" NK cells using standard protocols. Requirements for V(D)J recombination and a functional thymus, along with very low-level expression of surface TCRgammadelta but high intracellular CD3, define these cells as gammadelta T cells. "NK-like gammadelta T cells" are CD127+, have a memory-activated phenotype, express multiple NK cell receptors and readily produce interferon-gamma in response to IL-12/IL-18 stimulation. The close phenotypic resemblance between NK cells and NK-like gammadelta T cells is a source of experimental ambiguity in studies bridging NK and T cell biology, such as those on thymic NK cell development. Instead, it ascribes chronic TCRgammadelta engagement as a means of acquiring NK-like function.
Catalytic Combustion of Natural Gas Over Supported Platinum: Flow Reactor Experiments and Detailed Numerical Modeling (1996)

The use of a noble-metal combustion catalyst such as platinum or palladium in a natural-gas fired turbine can lower NOx (nitrogen oxides, consisting of both NO and NO2) emissions for two reasons. First, most of the combustion occurs on the catalyst surface; surface production of NOx is low or nonexistent. Second, the catalyst permits low temperature combustion below the traditional lean limit, thus inhibiting NOx formation routes in the gas phase. Due to the complexity of the catalytic combustion process, the catalyst has traditionally been modeled as a “black box” that produces a desired amount of fuel conversion. While this approach has been useful for proof-of-concept studies, we expect practical applications to emerge from a greater understanding of the details of the catalytic combustion process. We have constructed a numerical model of catalytic combustion based on the well-accepted CHEMKIN chemical kinetics formalism for gas-phase and surface chemistry. To support the model development, we built a research combustor. We present measured and modeled axial profiles of temperature, fuel conversion, and pollutant emissions for natural-gas combustion over platinum catalysts supported on ceramic honeycomb monoliths. NOx emissions are below 1 ppm, and CO is observed at ppm levels. The data are taken at several lean equivalence ratios and flow rates. Fuel conversion rates occur in two regimes: a low, constant conversion rate and a higher conversion rate that increases linearly with equivalence ratio. The agreement of the numerical model with the measured data is good at temperatures below 900 K; above this temperature, fuel conversion is underpredicted by as much as a factor of two. The predicted surface ignition temperatures agree well with the measured values. Results from the numerical model indicate that the fractional conversion rate of fuel has a linear dependence on the fraction of available surface reaction sites.
A Self-Similar Sine-Cosine Fractal Architecture for Multiport Interferometers (2023)

We propose a novel architecture for multiport interferometers based on the Sine-Cosine fractal decomposition of unitary matrices. Our design is modular, resilient to hardware imperfections and enables systematically truncated for use in optical neural networks.
Measurement of fluctuations affecting domain formation in transferred-electron logic devices using picosecond optical pulses (1982)

Picosecond optical pulses have been used to bias the gate region of a transferred-electron logic device to the vicinity of the threshold for domain formation. Single domains with rise and fall times of less than 50 ps are produced when the device is illuminated between the cathode and Schottky-barrier gate electrodes. The probability of domain generation is found to vary with optical intensity and applied bias voltage. Fitting a model of the effects of thermal carrier density fluctuations to these data yields a value for the rms fluctuating electric field component affecting domain formation of 123±14 V/cm in the devices studied.
Rapid and Stable Speed Response Based on Current Differential Signal and Priority Amplitude Method of SVM in Flux-Weakening Region of SPMSM (2015)

In the AC servo system, the output voltage is restricted by inverter output limitations. Voltage saturation occurs as a result of these limitations. The settling time of the current and speed increases because of voltage saturation. This paper proposes a new control system for improving the transient response of the surface permanent magnet synchronous motor (SPMSM) by using the proposed flux-weakening control based on the current differential signal. Because the current differential signal is taken into consideration, the suppression of voltage saturation is achieved with a smaller d-axis current in a transient state. Finally, this paper proposes a new combination method of flux-weakening control and an inverter modulation scheme, which makes it possible to improve the voltage utilization on condition of flux-weakening region. The proposed speed control system achieves a quick and stable speed and current response. The effectiveness of the proposed control methods is confirmed by both the numerical simulation results and the experimental results.
MRD detection in multiple myeloma: comparison between MSKCC 10-color single-tube and EuroFlow 8-color 2-tube methods (2017)

In patients with multiple myeloma, obtaining posttreatment minimal residual disease (MRD) negativity is associated with longer progression-free survival and overall survival. Here, we compared the diagnostic performance of a single 10-color tube with that of a EuroFlow 8-color 2-tube panel for MRD testing. Bone marrow samples from 41 multiple myeloma patients were tested in parallel using the 2 approaches. Compared with the sum of the cells from the EuroFlow two 8-color tubes, the Memorial Sloan Kettering Cancer Center (MSKCC) single 10-color tube had a slight reduction in total cell number with a mean ratio of 0.85 (range, 0.57-1.46; <i>P</i> < .05), likely attributable to permeabilization of the cells. Percent of plasma cells showed a high degree of concordance (<i>r</i><sup>2</sup> = 0.97) as did normal plasma cells (<i>r</i><sup>2</sup> = 0.96), consistent with no selective plasma cell loss. Importantly, concordant measurement of residual disease burden was seen with abnormal plasma cells (<i>r</i><sup>2</sup> = 0.97). The overall concordance between the 2 tests was 98%. In 1 case, there was a discrepancy near the limit of detection of both tests in favor of the slightly greater theoretical sensitivity of the EuroFlow 8-color 2-tube panel (analytical sensitivity limit of MSKCC single 10-color tube: 6 cells in 1 million with at least 3 million cell acquisitions; EuroFlow 8-color 2-tube panel: 2 cells in 1 million with the recommended 10 million cell acquisitions).
Macrocyclic functional dyes: Applications to optical disk media, photochemical hole burning and non-linear optics (1996)

Abstract