gebhart/patrepeval huggingface dataset:
HSPB1 Facilitates the Formation of Non-Centrosomal Microtubules (2013)

The remodeling capacity of microtubules (MT) is essential for their proper function. In mammals, MTs are predominantly formed at the centrosome, but can also originate from non-centrosomal sites, a process that is still poorly understood. We here show that the small heat shock protein HSPB1 plays a role in the control of non-centrosomal MT formation. The HSPB1 expression level regulates the balance between centrosomal and non-centrosomal MTs. The HSPB1 protein can be detected specifically at sites of de novo forming non-centrosomal MTs, while it is absent from the centrosomes. In addition, we show that HSPB1 binds preferentially to the lattice of newly formed MTs in vitro, suggesting that its function occurs by stabilizing MT seeds. Our findings open new avenues for the understanding of the role of HSPB1 in the development, maintenance and protection of cells with specialized non-centrosomal MT arrays.
Lack of in Vivo Insulin Resistance in Controlled Insulin-Dependent, Type I, Diabetic Patients* (1984)

Although type I diabetic patients are clearly insulin deficient, it is unclear whether they have normal in vivo sensitivity to insulin. Recent studies which suggested that insulin resistance is a common feature of insulin-dependent diabetics have not taken into account their degree of metabolic control or the presence of circulating antibodies. In the present study, we performed multiple euglycemic glucose clamp studies to construct insulin dose-response curves in 5 well controlled and 5 poorly controlled type I diabetic patients and 21 age-matched normal subjects. Each study was performed on a separate day at insulin infusion rates of 15, 40, 120, 240, or 1200 mU/M2 X min. During the 40 and 120 mU/M2 X min infusions, steady state insulin levels of 96 +/- 8 (+/- SE) and 285 +/- 27 microU/ml respectively, were achieved within 25 min in normal subjects. In contrast, diabetic subjects did not achieve steady state insulin levels (62 +/- 8 and 212 +/- 16 microU/ml) until 90 min of infusion, and insulin antibodies were detectable in the serum of all these patients. The dose-response curve for insulin stimulation of glucose disposal in well controlled diabetic subjects was comparable to that in normal subjects, with half-maximally effective insulin levels of 84 microU/ml in the diabetic patients compared to 70 microU/ml in normal subjects and virtually identical maximal rates of glucose disposal (433 +/- 11 vs. 411 +/- 17 mg/M2 X min in controls). In contrast, the dose-response curve for poorly controlled diabetic subjects was significantly right-shifted (half-maximally effective insulin level, 112 microU/ml), with marked reduction in the maximal glucose disposal rate (324 +/- 25 vs. 411 +/- 17 mg/M2 X min in normal subjects). Basal hepatic glucose output was increased in both poorly controlled and well controlled type I diabetic patients (132 +/- 7 and 101 +/- 16 mg/M2 X min, respectively) compared to normal subjects (76 +/- 7 mg/M2 X min). However, during each insulin infusion, hepatic glucose output was virtually 100% suppressed in all 3 groups.(ABSTRACT TRUNCATED AT 400 WORDS)
Dynamic virtual storage grid for mobile Web access (2004)

Advancement in wireless infrastructure for data access through third generation wireless and wi-fi technologies makes it possible to use mobile devices for various activities and transactions involving Internet. Several proposals have been made to provide data nearer to user. In this paper, we propose multiple overlay networks to provide a network infrastructure to support quick and efficient mobile access to the Web. The proposed overlay networks are storage overlay network to provide immediate access to personal information, xspot server overlay network to manage hotspots and to deliver both personal and public information, and cache overlay network to act as a vehicle for proactive and reactive information dissemination.
Extractable organic substances from New Zealand unifloral vipers bugloss (Echium vulgare) honey (1995)

SUMMARYThe levels of extractable organic substances in ten New Zealand unifloral vipers bugloss (Echium vulgare) honey samples were determined. The dominant extractive substance, present at levels of 16–28 mg/kg of honey, was identified as 1,4-dihydroxybenzene (hydroquinone). Lesser levels of 2,5-cyclohexadiene-1,4-dione (ben- zoquinone) and a number of para-disubstituted aromatic compounds were also detected in the extracts. 1,4-dihydroxybenzene is proposed as a floral marker compound for vipers bugloss (Echium vulgare) honey.
Thermal and Transition-Metal-Catalyzed Ring-Opening Polymerization (ROP) of [1]Silaferrocenophanes with Chlorine Substituents at Silicon:  A Route to Tunable Poly(ferrocenylsilanes) (1996)

The silicon-bridged [1]ferrocenophanes Fe(η-C5H4)2SiRR' [3 (R = Me, R' = Cl), 4 (R = R' = Cl)] with chlorine substituent(s) at silicon were prepared via the reaction of Fe(η-C5H4Li)2·TMEDA (TMEDA = tetramethylethylenediamine) with the chlorinated silanes MeSiCl3 and SiCl4, respectively. An X-ray diffraction study of 4 indicated that the cyclopentadienyl rings in this species are tilted by an angle of 19.2(4)°, typical of other structurally characterized silicon-bridged [1]ferrocenophanes. Thermal ring-opening polymerization (ROP) of 3 and 4 at 250 °C yielded the first high molecular weight poly(ferrocenylsilanes) with halogen substituents at silicon, [Fe(η-C5H4)2SiRR']n [7 (R = Me, R' = Cl), 8 (R = R' = Cl)]. Transition-metal-catalyzed polymerization of 3 and 4 with Pd and Pt catalysts also yielded polymers 7 and 8 in solution at room temperature. Polymer 7 was soluble in polar organic solvents and was characterized by 1H, 29Si, and 13C NMR and elemental analysis. In contrast, poly(ferrocenylsilane) 8 was found to be insoluble in organic solvents and this material was characterized by elemental analysis and derivatization. Substitution of the chlorine side groups in polymer 7 was achieved under mild conditions via reaction with the organolithium reagents MeLi, PhLi, and LiC⋮C(CH2)4H to afford the known polymers [Fe(η-C5H4)2SiMe2]n (2a) and [Fe(η-C5H4)2SiMePh]n (2d) and the new polymer [Fe(η-C5H4)2SiMeC⋮C(CH2)4H]n (9), respectively. The molecular weights for the completely halogen-substituted poly(ferrocenylsilanes) 2a, 2d, and 9 were estimated by gel permeation chromatography in THF to be in the range of Mw = 7.4 × 104 to 1.7 × 105 and Mn = 3.6 × 104 to 1.1 × 105 versus polystyrene standards. Substitution of the chlorine atoms in 8 was also demonstrated by reaction of the polymer with MeLi to give 2a.
Optimal Sensor Scheduling in Nonlinear Filtering of Diffusion Processes (1989)

The nonlinear filtering problem of a vector diffusion process is considered when several noisy vector observations with possibly different dimension of their range space are available. At each time any number of these observations (or sensors) can be used in the signal processing performed by the nonlinear filter. The problem considered is the optimal selection of a schedule of these sensors from the available set, so as to optimally estimate a function of the state at the final time. Optimality is measured by a combined performance measure that allocates penalties for errors in estimation, for switching between sensor schedules, and for running a sensor. The solution is obtained in the form of a system of quasi-variational inequalities in the space of solutions of certain Zakai equations.
Fourier, Fresnel, and Image CGHs of three-dimensional objects observed from many different projections (2004)

We describe new techniques of synthesizing three types of computer-generated hologram (CGH); Fourier, Fresnel and image CGHs. These holograms, aimed to reconstruct three-dimensional (3-D) objects, are synthesized by means of a unique algorithm of fusing multiple perspective views of the observed scene. The hologram is initially generated in the computer as a Fourier hologram. Then, it can be converted to either Fresnel or image holograms by computing the desired wave propagation and the interference process. By illuminating the ready-to-use CGHs with a collimated plane wave, a 3-D image of the objects is reconstructed. Diffraction efficiency enhancement of the above algorithm by superimposing a random phase on the object during the CGH formation is also presented. Computer simulation and experimental results of the constructed 3-D objects demonstrate the suggested technique
2-Amino-N-heteroaryl-nicotimamides as Nav1.8 Inhibitors (2020)

ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXT2-Amino-N-heteroaryl-nicotimamides as Nav1.8 InhibitorsBenjamin E. Blass*Benjamin E. BlassTemple University School of Pharmacy, Moulder Center for Drug Discovery Research, Department of Pharmaceutical Sciences, Philadelphia, Pennsylvania 19140, United States*Email: [email protected]More by Benjamin E. Blasshttp://orcid.org/0000-0003-2449-4503Cite this: ACS Med. Chem. Lett. 2020, 11, 12, 2354–2356Publication Date (Web):November 23, 2020Publication History Received26 October 2020Published online23 November 2020Published inissue 10 December 2020https://pubs.acs.org/doi/10.1021/acsmedchemlett.0c00568https://doi.org/10.1021/acsmedchemlett.0c00568editorialACS PublicationsCopyright © Published by American Chemical Society 2020. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1621Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (731 KB) Get e-AlertscloseSUBJECTS:Alkyls,Diseases and disorders,Group 17 compounds,Neurophysiology,Substituents Get e-Alerts
A new training set-up for trans-apical aortic valve replacement (2009)

Trans-apical aortic valve replacement (AVR) is a new and rapidly growing therapy. However, there are only few training opportunities. The objective of our work is to build an appropriate artificial model of the heart that can replace the use of animals for surgical training in trans-apical AVR procedures. To reduce the necessity for fluoroscopy, we pursued the goal of building a translucent model of the heart that has nature-like dimensions. A simplified 3D model of a human heart with its aortic root was created in silico using the SolidWorks Computer-Aided Design (CAD) program. This heart model was printed using a rapid prototyping system developed by the Fab@Home project and dip-coated two times with dispersion silicone. The translucency of the heart model allows the perception of the deployment area of the valved-stent without using heavy imaging support. The final model was then placed in a human manikin for surgical training on trans-apical AVR procedure. Trans-apical AVR with all the necessary steps (puncture, wiring, catheterization, ballooning etc.) can be realized repeatedly in this setting.
Discovery of inhibitors for the human chemokine receptors CXCR4 and CXCR7: screening applications on the FLIPR Tetra high-throughput cellular screening system (2016)

status: Published
Minimum inhibitory and bactericidal concentrations of theaflavin and syngergistic combinations with epicatechin and quercetin against clinical isolates of Stenotrophomonas maltophilia (2012)

Stenotrophomonas maltophilia is an important nosocomial pathogen with intrinsic resistance to multiple antibiotics. Previous investigations have shown flavanols from black tea to possess antibacterial activity. This study describes the determination of minimum inhibitory concentrations and minimum bactericidal concentration for theaflavin independently and in formulations with the polyphenols epicatechin and quercetin against nine clinical isolates of Stenotrophomonas maltophilia and the control isolate NCTC 130141 via the microtitre assay. The results demonstrate that theaflavin has strong antibacterial activity and also shows significant synergism with epicatechin and quercetin. The minimum inhibitory concentrations of the isolates range between 200-400 ug/mL for theaflavin and 100-200 ug/mL for both theaflavin:epicatechin and theaflavin:quercetin combinations. The minimum bactericidal concentrations were discovered to be a 2 fold increase on those of the minimum inhibitory concentrations. The research highlights the potential use of polyphenols for the clinical treatment of highly antibiotic resistant bacteria.
Fluoroelastomer Fouling Release Coating (1998)

Abstract : Our goal is to develop novel fluoroelastomers that exhibit fouling release capabilities and to understand the polymer characteristics that influence the adhesion of biofouling organisms to polymeric substrates. We will develop novel fluoroelastomers that are characterized by low glass transition temperature and the ability to form stable, low surface energy coatings with high abrasion resistance and excellent adhesion to substrates. We will study the physical, surface, mechanical, and thermal properties of these polymeric materials to correlate polymer properties with the ability to reduce adhesion of fouling organisms. Based on the results of marine use tests, we will select most promising coating formulations, conduct additional fouling release use tests, and identify one formulation with the most desirable characteristics for further development.
A Nonlinear Model for Hippocampal Cognitive Prosthesis: Memory Facilitation by Hippocampal Ensemble Stimulation (2012)

Collaborative investigations have characterized how multineuron hippocampal ensembles encode memory necessary for subsequent successful performance by rodents in a delayed nonmatch to sample (DNMS) task and utilized that information to provide the basis for a memory prosthesis to enhance performance. By employing a unique nonlinear dynamic multi-input/multi-output (MIMO) model, developed and adapted to hippocampal neural ensemble firing patterns derived from simultaneous recorded CA1 and CA3 activity, it was possible to extract information encoded in the sample phase necessary for successful performance in the nonmatch phase of the task. The extension of this MIMO model to online delivery of electrical stimulation delivered to the same recording loci that mimicked successful CA1 firing patterns, provided the means to increase levels of performance on a trial-by-trial basis. Inclusion of several control procedures provides evidence for the specificity of effective MIMO model generated patterns of electrical stimulation. Increased utility of the MIMO model as a prosthesis device was exhibited by the demonstration of cumulative increases in DNMS task performance with repeated MIMO stimulation over many sessions on both stimulation and nonstimulation trials, suggesting overall system modification with continued exposure. Results reported here are compatible with and extend prior demonstrations and further support the candidacy of the MIMO model as an effective cortical prosthesis.
Self-Splicing and Enzymatic Activity of an Intervening Sequence RNA from Tetrahymena (2004)

Research Article| August 17 2005 Self-Splicing and Enzymatic Activity of an Intervening Sequence RNA from Tetrahymena Thomas R. Cech Thomas R. Cech 1Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, 80309-0215, USA Search for other works by this author on: This Site PubMed Google Scholar Biosci Rep (2004) 24 (4-5): 362–385. https://doi.org/10.1007/s10540-005-2738-3 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Thomas R. Cech; Self-Splicing and Enzymatic Activity of an Intervening Sequence RNA from Tetrahymena. Biosci Rep 10 August 2004; 24 (4-5): 362–385. doi: https://doi.org/10.1007/s10540-005-2738-3 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBioscience Reports Search Advanced Search Keywords: RNA, self-splicing, enzymatic activity This content is only available as a PDF. © 2005 Springer Science+Business Media, Inc.2005 Article PDF first page preview Close Modal You do not currently have access to this content.
Teaching-less robot system for finishing workpieces of various shapes using force control and computer vision (2003)

In the case of conventional industrial robot systems, operators have to write robot-language programs for each type of workpiece. This is an onerous task, especially when each workpiece has a different shape. We propose a teaching-less robot system for the finishing of two-dimensional workpieces of various shapes and thicknesses using force control and computer vision. The robot system does not require shape information for the workpiece to be included in the CAD data or to be input by the operator. Each workpiece shape is acquired by segmenting edges into straight lines and circular arcs from the image data of the workpiece. The robot-language program for each workpiece is generated automatically from the workpiece shape data and finishing condition data. The effectiveness of the proposed method is verified by experiments using a newly developed robot system. In the system, the robot picks up a workpiece whose shape is not previously known on the workpiece stand by itself and carries out the finishing tasks using the automatically generated robot-language program. This method provides a compact and inexpensive finishing robot system which reduces the programming and workpiece-setting burden on the operators.
Shining light on CO2: from materials discovery to photocatalyst, photoreactor and process engineering (2020)

Heterogeneous catalysis, a process in which the reaction of gaseous or liquid chemical reagents is facilitated at the surface of a solid material, is responsible for the majority of industrial-scale chemical and fuel production reactions. The energy required to drive these reactions has historically been derived from the combustion of non-renewable fossil fuels and carries an unavoidably large carbon footprint. More recently, the development of environmentally responsible and sustainable chemical industries is increasingly motivated by greenhouse gas-induced climate change, thus creating demand for eco-friendly heterogeneous catalytic processes. This includes innovative approaches enabled by renewable forms of energy, such as the electrification of chemical and petrochemical processes, utilization of CO<sub>2</sub> as a feedstock and the incorporation of light into catalytic reactions. Herein we review the conversion of solar energy to chemical energy using CO<sub>2</sub>, and describe how the photophysical and photochemical properties of nanostructured metal oxide photocatalysts have been engineered to efficiently incorporate light into heterogeneous gas-solid CO<sub>2</sub> hydrogenation reactions. Realizing high photonic and energy efficiencies in these systems has demanded innovation in not only photocatalyst engineering, but also photoreactor and process engineering. Rather than exclusively providing an in-depth discussion of the chemistry and science within each individual study, this Tutorial Review highlights the multidisciplinary character of photocatalysis studies by covering the four essential components of a typical research work in this field (materials engineering, theoretical modelling, reactor engineering and process development) <i>via</i> case studies of the archetypal indium oxide catalyst materials. Through advances in these four components, progress has been made towards the ultimate goal of industrializing the production of CO<sub>2</sub>-derived chemicals and fuels.
Continuous Implicit Authentication through Touch Traces Modelling (2020)

Nowadays, the continuously increasing use of smart-phones as the primary way of dealing with day-to-day tasks raises several concerns mainly focusing on privacy and security. In this context and given the known limitations and deficiencies of traditional authentication mechanisms, a lot of research efforts are targeted towards continuous implicit authentication on the basis of behavioral biometrics. In this work, we propose a methodology towards continuous implicit authentication that refrains from the limitations imposed by small-scale and/or controlled environment experiments by employing a real-world application used widely by a large number of individuals. Upon constructing our models using Support Vector Machines, we introduce a confidence-based methodology, in order to strengthen the effectiveness and the efficiency of our approach. The evaluation of our methodology on a set of diverse scenarios indicates that our approach achieves good results both in terms of efficiency and usability.
Development of Epitaxial Thin Film Model Electrodes for the Systematic Investigation of Metal Exsolution from MIEC Perovskite Oxides (2019)

Metal exsolution of catalytically active B-site dopants of mixed ion and electron conducting (MIEC) perovskites under reducing conditions can be utilized for the preparation of high-performance electrode materials. To study the underlying mechanisms of the exsolution process with respect to specific material aspects - for example structural properties of the host lattice - advanced model systems with well-defined properties are required. Pulsed laser deposition (PLD), enables the fabrication of such model electrode systems by epitaxial growth of complex oxides with highly defined and tunable structural properties. In this study, we present the development of epitaxial model electrodes of Nb and Ni co-doped strontium titanate (SrTi0.9Nb0.05Ni0.05O3-δ, STNNi) by PLD. We discuss epitaxial growth and material properties providing well-defined thin film model electrodes suitable for the investigation of nanoparticle exsolution.
Multi-dimensional data transmission using inverse-designed silicon photonics and microcombs (2022)

The use of optical interconnects has burgeoned as a promising technology that can address the limits of data transfer for future high-performance silicon chips. Recent pushes to enhance optical communication have focused on developing wavelength-division multiplexing technology, and new dimensions of data transfer will be paramount to fulfill the ever-growing need for speed. Here we demonstrate an integrated multi-dimensional communication scheme that combines wavelength- and mode- multiplexing on a silicon photonic circuit. Using foundry-compatible photonic inverse design and spectrally flattened microcombs, we demonstrate a 1.12-Tb/s natively error-free data transmission throughout a silicon nanophotonic waveguide. Furthermore, we implement inverse-designed surface-normal couplers to enable multimode optical transmission between separate silicon chips throughout a multimode-matched fibre. All the inverse-designed devices comply with the process design rules for standard silicon photonic foundries. Our approach is inherently scalable to a multiplicative enhancement over the state of the art silicon photonic transmitters.