gebhart/patrepeval huggingface dataset:
Inhibition of geranylgeranyltransferase attenuates neutrophil accumulation and tissue injury in severe acute pancreatitis (2013)

Leukocyte infiltration and acinar cell necrosis are hallmarks of severe AP, but the signaling pathways regulating inflammation and organ injury in the pancreas remain elusive. In the present study, we investigated the role of geranylgeranyltransferase in AP. Male C57BL/6 mice were treated with a geranylgeranyltransferase inhibitor GGTI-2133 (20 mg/kg) prior to induction of pancreatitis by infusion of taurocholate into the pancreatic duct. Pretreatment with GGTI-2133 reduced plasma amylase levels, pancreatic neutrophil recruitment, hemorrhage, and edema formation in taurocholate-evoked pancreatitis. Moreover, administration of GGTI-2133 decreased the taurocholate-induced increase of MPO activity in the pancreas and lung. Treatment with GGTI-2133 markedly reduced levels of CXCL2 in the pancreas and IL-6 in the plasma in response to taurocholate challenge. Notably, geranylgeranyltransferase inhibition abolished neutrophil expression of Mac-1 in mice with pancreatitis. Finally, inhibition of geranylgeranyltransferase had no direct effect on secretagogue-induced activation of trypsinogen in pancreatic acinar cells in vitro. A significant role of geranylgeranyltransferase was confirmed in an alternate model of AP induced by L-arginine challenge. Our findings show that geranylgeranyltransferase regulates neutrophil accumulation and tissue damage via expression of Mac-1 on neutrophils and CXCL2 formation in AP. Thus, these results reveal new signaling mechanisms in pancreatitis and indicate that targeting geranylgeranyltransferase might be an effective way to ameliorate severe AP.
Interactive display system having a scaled virtual target zone (2023)

A display system includes a waveguide optical panel having an inlet face and an opposite outlet face. A projector and imaging device cooperate with the panel for projecting a video image thereon. An optical detector bridges at least a portion of the waveguides for detecting a location on the outlet face within a target zone of an inbound light spot. A controller is operatively coupled to the imaging device and detector for displaying a cursor on the outlet face corresponding with the detected location of the spot within the target zone.
Wide-Band SIMO 1&lt;tex&gt;$,times,$&lt;/tex&gt;2 Measurements and Characterization of Outdoor Wireless Channels at 1.9 GHz (2004)

This paper aims at characterizing the spatial wireless channel at 1.9 GHz, based on a 1/spl times/2 measurement chain. A typical campus/residential area and an industrial area have been investigated. The measurement equipment is constituted by an 80-MHz transmitter at 1.9 GHz, located at the top of a building. At the receiver, two omnidirectional antennas are connected to a wide-band channel sounder through a switch in order to measure an estimate of the instantaneous vector channel. It is found that the Ricean K-factor and the delay spread are lognormally distributed, while the azimuth spread at the receive side follows a Gaussian distribution. The range dependence of various parameters are pointed out and compared with empirical models. The impacts of antenna spacing and array orientation on the channel correlation are highlighted and compared to theoretical simulation results. Finally, the cross-correlation properties between K-factor, delay spread, azimuth spread, and channel correlation are analyzed.
Glia as a Link between Neuroinflammation and Neuropathic Pain (2012)

Contemporary studies illustrate that peripheral injuries activate glial components of the peripheral and central cellular circuitry. The subsequent release of glial stressors or activating signals contributes to neuropathic pain and neuroinflammation. Recent studies document the importance of glia in the development and persistence of neuropathic pain and neuroinflammation as a connecting link, thereby focusing attention on the glial pathology as the general underlying factor in essentially all age-related neurodegenerative diseases. There is wide agreement that excessive glial activation is a key process in nervous system disorders involving the release of strong pro-inflammatory cytokines, which can trigger worsening of multiple disease states. This review will briefly discuss the recent findings that have shed light on the molecular and cellular mechanisms of glia as a connecting link between neuropathic pain and neuroinflammation.
Cortical thickness analysis of the proximal humerus (2017)

In conclusion, this is the first study to comprehensively assess cortical thickness of the humeral head. Our findings suggest that proximal humeral fractures occur along lines of cortical thinning and are displaced by the hard glenoid bone. The identification of specific areas of thick cortices may improve pre-operative planning and optimize fracture fixation.
Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression (2016)

Combination studies of neurokinin 1 (NK1) receptor antagonists and serotonin-selective reuptake inhibitors (SSRIs) have shown promise in preclinical models of depression. Such a combination may offer important advantages over the current standard of care. Herein we describe the discovery and optimization of an indazole-based chemotype to provide a series of potent dual NK1 receptor antagonists/serotonin transporter (SERT) inhibitors to overcome issues of ion channel blockade. This effort culminated in the identification of compound 9, an analogue that demonstrated favorable oral bioavailability, excellent brain uptake, and robust in vivo efficacy in a validated depression model. Over the course of this work, a novel heterocycle-directed asymmetric hydrogenation was developed to facilitate installation of the key stereogenic center.
Mechanism of the Meerwein−Ponndorf−Verley−Oppenauer (MPVO) Redox Equilibrium on Sn− and Zr−Beta Zeolite Catalysts (2006)

The mechanism of the Meerwein-Ponndorf-Verley (MPV) reduction of cyclohexanone with 2-butanol catalyzed by Sn-beta and Zr-beta zeolites has been theoretically investigated using density functional theory (DFT) and the cluster approach. An experimental catalytic study has shown that the active sites in the MPV reaction catalyzed by Sn-beta are the same partially hydrolyzed Sn-OH groups that were found to be active for the Baeyer-Villiger (BV) reaction. The computational study indicates that the mechanism of Sn-beta and Zr-beta catalysis is similar, and involves the following steps: adsorption of both the ketone and the alcohol on the Lewis acid center, deprotonation of the alcohol, carbon-to-carbon hydride transfer, proton transfer from the catalyst, and products exchange. As in the aluminum alkoxide catalyzed reaction, the hydride shift occurs through a six-membered transition state, and the role of the hydrolyzed and therefore more flexible M-OH bond is just to facilitate the initial deprotonation of the alcohol.
Testing a new NIF neutron time-of-flight detector with a bibenzyl scintillator on OMEGA (2012)

A new neutron time-of-flight (nTOF) detector with a bibenzyl crystal as a scintillator has been designed and manufactured for the National Ignition Facility (NIF). This detector will replace a nTOF20-Spec detector with an oxygenated xylene scintillator currently operational on the NIF to improve the areal-density measurements. In addition to areal density, the bibenzyl detector will measure the D-D and D-T neutron yield and the ion temperature of indirect- and direct-drive-implosion experiments. The design of the bibenzyl detector and results of tests on the OMEGA Laser System are presented.
Use of Ribozymes in Cellular Aging Research (2007)

Ribozymes are naturally-occurring catalytic RNAs from the viroid world and are being engineered in the laboratory to perform sequence-specific cleavage of a desired mRNA target. Since their Nobel Prize-winning discovery, there has been considerable interest in the utility of ribozymes as gene therapeutic agents to silence disease-causing genes. This technology is not perfect, but extensive efforts to improve upon natural design of ribozymes have enabled these RNA molecules to perform various tasks. In this chapter, we highlight the construction of two types of ribozymes: conventional and hybrid hammerhead ribozymes. The hybrid ribozyme described here is an improved version of the basic hammerhead motif with the following features: (a) the use of the RNA polymerase III (polIII) tRNAVal promoter to achieve a high level of transcription, (b) 5' linkage to the cloverleaf-shaped tRNAVal to enhance intracellular stability and cytoplasmic transport, and (c) a 3' end poly-(A) tail to act as a "molecular anchor" for endogenous RNA helicases endowing the ribozyme ability to disentangle higher-order structures of the target mRNA. Randomized hybrid ribozyme libraries have been used successfully for revelation of gene functions involved in metastasis, invasion, differentiation, apoptosis, endoplasmic reticulum stress and may be extended to gene functions involved in innate or induced cellular senescence of human cells.
Tourism–Growth Nexus in the Presence of Instability (2022)

This paper contributes to the tourism–growth literature by applying the new vector autoregressive-based Granger causality test in the presence of instability to reassess the Granger causality between Hong Kong’s tourism and economic growth. The results of the traditional and recursive Granger causality test under the VAR framework show that the tourism-led economic growth hypothesis (TLEGH) and the economy-driven tourism growth hypothesis (EDTGH) are both unstable in Hong Kong. The results of the vector autoregressive-based Granger causality test in the presence of instability generally support bidirectional causality between tourism and economic growth. However, the relationship between tourism and economic growth is vulnerable to sudden major political incidents, public health incidents, and financial crises. Among these incidents and crises, political events have long-term effects on the relationship between Hong Kong’s tourism and economic growth. In contrast, economic policies, financial crises, and public health emergencies have short-term impacts on the relationship.
Diversity Schemes in Multi-hop Visible Light Communications for 6G Networks (2021)

With the fast-emerging trend of deploying Internet-of-things (IoT) in smart homes and cities, next-generation wireless systems (i.e., beyond fifth-generation (5G) of wireless mobile communications) are expected to connect a plurality of devices, including machines, sensors, tablets, cameras, etc. To this end, the radio frequency (RF) spectrum would fail to fulfill the demands of such enormous data-heavy wireless applications, as operating at the RF spectrum would largely suffer from data congestion and interference. Based on the potential of Visible Light Communications (VLC) to solve the problem of spectrum scarcity and satisfy the high data-rate requirements of beyond 5G systems, this paper focuses on utilizing VLC for IoT applications in indoor environments by means of adequately routing data among VLCbased nodes. Operating at the unlicensed optical band in the visible light region utilizes simple Light-Emitting-Diodes (LEDs), which is a health-friendly communication method. VLC has the advantages of providing ultra-high bandwidth, robustness to electromagnetic interference, and inherent physical security. VLC, however, suffers from severe short communication ranges and line-of-sight (LoS) constraints. This paper proposes overcoming such challenges by means of adopting a transmit diversity scheme that transmits messages over several paths. In order to reduce the receiver outage probability, the paper proposes multiple combination schemes at the receiver side, namely selection combining, maximal-ratio combining, and threshold combining. The simulation results assess the effectiveness of the proposed diversity schemes in terms of signal-to-noise-ratio and outage probability and illustrate the suitability of deploying VLC for next-generation indoor networks. The results show that that maximal-ratio combining outperforms selection combining and threshold combining by approximately 10% and 40%, respectively.
ARTICLES Robust control of quantum information (2013)

Errors in the control of quantum systems may be classified as unitary, decoherent, and incoherent. Unitary errors are systematic, and result in a density matrix that differs from the desired one by a unitary operation. Decoherent errors correspond to general completely positive superoperators, and can only be corrected using methods such as quantum error correction. Incoherent errors can also be described, on average, by completely positive superoperators, but can nevertheless be corrected by the application of a locally unitary operation that ‘‘refocuses’’ them. They are due to reproducible spatial or temporal variations in the system’s Hamiltonian, so that information on the variations is encoded in the system’s spatiotemporal state and can be used to correct them. In this paper liquid-state nuclear magnetic resonance is used to demonstrate that such refocusing effects can be built directly into the control fields, where the incoherence arises from spatial inhomogeneities in the quantizing static magnetic field as well as the radio-frequency control fields themselves. Using perturbation theory, it is further shown that the eigenvalue spectrum of the completely positive superoperator exhibits a characteristic spread that contains information on the Hamiltonians’ underlying distribution. © 2003 American Institute of Physics. @DOI: 10.1063/1.1619132#
Fabrication of particulate rutile TiO2/Al composites by squeeze casting and their structural characteristics. (1993)

** homogeneous composites was composed of fine -Al2O3 dispersed in the Al-Ti
Design of gain-flattened highly nonlinear photonic crystal fiber Raman amplifier using a single pump: a leakage loss approach (2006)

We present a novel inherent gain-flattened design of highly nonlinear photonic crystal fiber Raman amplifier exhibiting /spl plusmn/0.85-dB gain-ripples over 28-nm bandwidth using a single pump in C-band employing the leakage loss property with integrated dispersion compensation functionality.
Octupole electrode pattern for tuning forks vibrating at the first overtone mode in quartz-enhanced photoacoustic spectroscopy (2018)

The design, realization, and performance analysis of an octupole electrode pattern configuration intended for the optimization of the charge collection efficiency in quartz tuning forks (QTFs) vibrating at the first overtone in-plane flexural mode is reported. Two QTFs having the same geometry, but differing in the electrode pattern deposited on the QTF prongs, have been realized in order to study the influence of the electrode pattern on the resonance quality factor and electrical resistance. A standard quadrupole pattern (optimized for the fundamental mode) and an octupole electrode layout have been implemented. Although both QTFs show the same resonance quality factor for the first overtone, the octupole pattern provides a reduction of the QTF electrical resistance by more than four times. The sensing performance of the two QTFs has been compared by employing them in a mid-IR quartz-enhanced photoacoustic sensor (QEPAS) system targeting a water absorption line. When operating at the first overtone mode, the QTF with an octupole electrode pattern provides a QEPAS signal more than two times higher with respect to the QTF employing the standard quadrupole configuration.
Overall and Adiabatic Effectiveness Values on a Scaled Up, Simulated Gas Turbine Vane: Part I—Experimental Measurements (2011)

Recent advances in computational power have made conjugate heat transfer simulations of fully conducting, film cooled turbine components feasible. However, experimental data available with which to validate conjugate heat transfer simulations is limited. This paper presents experimental measurements of external surface temperature on the suction side of a scaled up, fully conducting, cooled gas turbine vane. The experimental model utilizes the matched Bi method, which produces non-dimensional surface temperature measurements that are representative of engine conditions. Adiabatic effectiveness values were measured on an identical near adiabatic vane with an identical geometry and cooling configuration. In addition to providing a valuable data set for computational code validation, the data shows the effect of film cooling on the surface temperature of a film cooled part. As expected, in nearly all instances the addition of film cooling was seen to decrease the overall surface temperature. However, due to the effect of film injection causing early boundary layer transition, film cooling at a high momentum flux ratio was shown to actually increase surface temperature over 0.35 &lt; s/C &lt; 0.45.
Brightening and Control of Quenched Quantum Dots with Strong Terahertz Pulses (2021)

We demonstrate the reversible brightening of quenched quantum dot photoluminescence using high-field-strength short terahertz pulses. This effect is attributed to the removal of excess charges and the subsequent reduction in nonradiative Auger recombination.
Therapy of refractory/relapsed metastatic triple-negative breast cancer (TNBC) with an anti-Trop-2-SN-38 antibody-drug conjugate (ADC), sacituzumab govitecan (IMMU-132): Phase I/II clinical experience. (2015)

1016 Background: Patients with metastatic TNBC have an aggressive disease with limited therapy options. The duration of response with standard chemotherapy is usually short, with median PFS of about 3-4 months, and there is an unmet need for better therapies. Trop-2 is highly expressed in most epithelial cancers, including TNBC ( > 90%). IMMU-132 is a conjugate of a humanized anti-Trop-2 (trophoblast cell-surface antigen) mAb coupled site-specifically to SN-38 (7.6 moles SN-38/IgG), the active metabolite of irinotecan, using a proprietary linker. Methods: In an ongoing Phase I/II clinical trial (ClinicalTrials.gov, NCT01631552), patients with metastatic TNBC patients refractory or relapsing to prior therapies, including topoisomerase inhibitors, received IMMU-132 i.v. on days 1 and 8 of 21-day treatment cycles. Treatment was continued based on tolerance or until progression, with safety and response assessments (RECIST1.1) made every week and at 8-12 weeks, respectively. Dose reductions/delays allowed most patients to continue treatment until progression. Results: As of Feb 2, 2015, a total of 174 pts with relapsed/refractory diverse epithelial tumors have been treated with IMMU-132. Forty-eight pts with TNBC were treated: median age = 51 ys (range, 33-81), median of 4 prior chemotherapies (range, 1-11). In TNBC, Grade 3/4 toxicities included neutropenia (G3, 24%; G4, 6%) and febrile neutropenia (G4, 3%). Other G3 toxicities included diarrhea (3%), anemia (3%), leucopenia (3%), lymphopenia (3%), caecitis (3%). No pt developed antibodies to the conjugate; no one discontinued due to toxicity. Thirty-four TNBC pts had at least 1 response assessment, with an objective response rate (ORR) of 21% (including one complete response), a disease stabilization rate (CR+PR+SD) of 74%, and a clinical benefit ratio with CR+PR+SD ≥ 6 mo = 37% (7 of 15 pt with SD are still on treatment). Conclusions: IMMU-132 therapy is associated with encouraging clinical activity and limited toxicity in patients with metastatic TNBC s/p multiple prior lines of therapy. It warrants further evaluation for this refractory disease. Clinical trial information: NCT01631552.
Effects of pH alteration on respiratory syncytial virus in human airway epithelial cells (2023)

Optate inhibits RSV infection in primary HAECs in a dose-dependent manner. These findings suggest that Optate may have potential as an inhaled therapeutic for patients with RSV.
Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE/choroid by RNA-Seq (2014)

Proper spatial differentiation of retinal cell types is necessary for normal human vision. Many retinal diseases, such as Best disease and male germ cell associated kinase (MAK)-associated retinitis pigmentosa, preferentially affect distinct topographic regions of the retina. While much is known about the distribution of cell types in the retina, the distribution of molecular components across the posterior pole of the eye has not been well-studied. To investigate regional difference in molecular composition of ocular tissues, we assessed differential gene expression across the temporal, macular, and nasal retina and retinal pigment epithelium (RPE)/choroid of human eyes using RNA-Seq. RNA from temporal, macular, and nasal retina and RPE/choroid from four human donor eyes was extracted, poly-A selected, fragmented, and sequenced as 100 bp read pairs. Digital read files were mapped to the human genome and analyzed for differential expression using the Tuxedo software suite. Retina and RPE/choroid samples were clearly distinguishable at the transcriptome level. Numerous transcription factors were differentially expressed between regions of the retina and RPE/choroid. Photoreceptor-specific genes were enriched in the peripheral samples, while ganglion cell and amacrine cell genes were enriched in the macula. Within the RPE/choroid, RPE-specific genes were upregulated at the periphery while endothelium associated genes were upregulated in the macula. Consistent with previous studies, BEST1 expression was lower in macular than extramacular regions. The MAK gene was expressed at lower levels in macula than in extramacular regions, but did not exhibit a significant difference between nasal and temporal retina. The regional molecular distinction is greatest between macula and periphery and decreases between different peripheral regions within a tissue. Datasets such as these can be used to prioritize candidate genes for possible involvement in retinal diseases with regional phenotypes.
Influence of Low Fractions of Styrene/Butyl Acrylate Polymer Latexes on Some Properties of Ordinary Portland Cement Mortars (2007)

Abstract The influence of the chemical structure of styrene/butyl acrylate latexes on some properties of ordinary Portland cement mortars has been investigated for low fractions of polymer with respect to the amount of cement. The structural parameters that were varied included the presence of carboxylic surface charges, the nature of the surfactant system, the molecular weight of the non‐ionic emulsifier, and the particle surface coverage. The first part of the study showed that sterically stabilised latexes remain colloidally and chemically stable for several hours in the cement interstitial medium. Moreover, no interaction could be shown between cement and latex components. Then, for a fraction of about 5wt.‐% of polymer, no significant influence of the presence of the latex was observed on the end‐use properties of the mortars. However, it clearly appears that the use of a fraction of anionic stabiliser is highly detrimental to the paste workability, whereas this latter property is improved by the presence of non‐ionic surfactant due to steric repulsion forces. Finally, the microstructure analysis confirms that the particles are homogenously dispersed in the mineral matrix and that they remain smooth and spherical. magnified image