gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Application of Combinatorial Chemistry Science on Modern Drug Discovery (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Compact Hip-Force Sensor for a Gait-Assistance Exoskeleton System (2018)

In this paper, we propose a compact force sensor system for a hip-mounted exoskeleton for seniors with difficulties in walking due to muscle weakness. It senses and monitors the delivered force and power of the exoskeleton for motion control and taking urgent safety action. Two FSR (force-sensitive resistors) sensors are used to measure the assistance force when the user is walking. The sensor system directly measures the interaction force between the exoskeleton and the lower limb of the user instead of a previously reported force-sensing method, which estimated the hip assistance force from the current of the motor and lookup tables. Furthermore, the sensor system has the advantage of generating torque in the walking-assistant actuator based on directly measuring the hip-assistance force. Thus, the gait-assistance exoskeleton system can control the delivered power and torque to the user. The force sensing structure is designed to decouple the force caused by hip motion from other directional forces to the sensor so as to only measure that force. We confirmed that the hip-assistance force could be measured with the proposed prototype compact force sensor attached to a thigh frame through an experiment with a real system.
THE POWERFUL T-CELL TOLERIZING CONSEQUENCES OF BLOCKING EXPRESSION OF PRO-, NOT ANTI-INFLAMMATORY MECHANISM (2008)

Koulmanda, M; Hoffman, L; Qipo, A; Hanidziar, D; Shi, H; Fan, Z; Flier, J F.; Strom, T B. Author Information
Dynamic nuclear polarization of quadrupolar nuclei using cross polarization from protons: surface-enhanced aluminium-27 NMR (2012)

The surface of γ-alumina nanoparticles can be characterized by dynamic nuclear polarization (DNP) surface-enhanced NMR of (27)Al. DNP is combined with cross-polarization and MQ-MAS to determine local symmetries of (27)Al sites at the surface.
[Successful treatment with cidofovir for disseminated adenovirus infection accompanied by hemophagocytic syndrome and meningitis in an allogeneic hematopoietic stem cell transplantation recipient]. (2021)

A 65-year-old woman received bone marrow transplantation from an HLA-DRB1 one locus mismatched donor for high-risk myelodysplastic syndrome. On day 237 after transplantation, she developed recurrent acute gastrointestinal graft-versus-host disease and adenoviral hemorrhagic cystitis. Hence, the methylprednisolone (mPSL) dose was increased to 2 mg/kg, and mesenchymal stem cells were administered. After the dose was tapered, she developed high fever, gross hematuria, and progressive pancytopenia. Then, the serum LDH, ferritin, and hepatobiliary enzyme levels of the patient increased, and hemophagocytosis was observed based on bone marrow examination. The adenovirus DNA level in the plasma was 6.3×10<sup>6</sup> copies/ml on day 278, and the volume of cerebrospinal fluid increased. Hence, the patient was diagnosed with meningitis and disseminated adenovirus infection. On day 288, cidofovir was administered at a dose of 1 mg/kg three times a week for 8 doses. The mPSL dose was again increased to 2 mg/kg for the treatment of hemophagocytic syndrome. Then, the patient's symptoms gradually improved, and the adenovirus viral load became negative on day 369. Based on the clinical course of our patient, cidofovir is useful for severe adenovirus infection.
Human 76p (1999)

The role of the centrosomes in microtubule nucleation remains largely unknown at the molecular level. gamma-Tubulin and the two associated proteins h103p (hGCP2) and h104p (hGCP3) are essential. These proteins are also present in soluble complexes containing additional polypeptides. Partial sequencing of a 76- kD polypeptide band from these complexes allowed the isolation of a cDNA encoding for a new protein (h76p = hGCP4) expressed ubiquitously in mammalian tissues. Orthologues of h76p have been characterized in Drosophila and in the higher plant Medicago. Several pieces of evidence indicate that h76p is involved in microtubule nucleation. (1) h76p is localized at the centrosome as demonstrated by immunofluorescence. (2) h76p and gamma-tubulin are associated in the gamma-tubulin complexes. (3) gamma-tubulin complexes containing h76p bind to microtubules. (4) h76p is recruited to the spindle poles and to Xenopus sperm basal bodies. (5) h76p is necessary for aster nucleation by sperm basal bodies and recombinant h76p partially replaces endogenous 76p in oocyte extracts. Surprisingly, h76p shares partial sequence identity with human centrosomal proteins h103p and h104p, suggesting a common protein core. Hence, human gamma-tubulin appears associated with at least three evolutionary related centrosomal proteins, raising new questions about their functions at the molecular level.
Monte Carlo simulation of proton SFRT (2023)

Schneider <i>et al</i> discuss proton spatially fractionated radiation therapy Monte Carlo simulations and provide unique insights into simulation techniques and practical approaches in chapter 19.
When caches aren't enough: data prefetching techniques (1997)

With data prefetching, memory systems call data into the cache before the processor needs it, thereby reducing memory-access latency. Using the most suitable techniques is critical to maximizing data prefetching's effectiveness. The authors review three popular prefetching techniques: software-initiated prefetching, sequential hardware-initiated prefetching, and prefetching via reference prediction tables.
Refractory Hodgkin Lymphoma (2013)

Recent therapeutic advances have improved the prognosis of Hodgkin Lymphoma by prevention or successful treatment of refractory disease. The use of new drugs such as brentuximab vedotin will hopefully further increase the cure rates.
Identification of Candidate Mitochondrial Inheritance Determinants Using the Mammalian Cell-Free System (2023)

Abstract The degradation of sperm-borne mitochondria after fertilization is a conserved event. This process known as post-fertilization sperm mitophagy, ensures exclusively maternal inheritance of the mitochondria-harbored mitochondrial DNA genome. This mitochondrial degradation is in part carried out by the ubiquitin-proteasome system. In mammals, ubiquitin-binding pro-autophagic receptors such as SQSTM1 and GABARAP have also been shown to contribute to sperm mitophagy. These systems work in concert to ensure the timely degradation of the sperm-borne mitochondria after fertilization. We hypothesize that other receptors, cofactors, and substrates are involved in post-fertilization mitophagy. Mass spectrometry was used in conjunction with a porcine cell-free system to identify other autophagic cofactors involved in post-fertilization sperm mitophagy. This porcine cell-free system is able to recapitulate early fertilization proteomic interactions. Altogether, 185 proteins were identified as statistically different between control and cell-free treated spermatozoa. Six of these proteins were further investigated, including MVP, PSMG2, PSMA3, FUNDC2, SAMM50, and BAG5. These proteins were phenotyped using porcine in vitro fertilization, cell imaging, proteomics, and the porcine cell-free system. The present data confirms the involvement of known mitophagy determinants in the regulation of mitochondrial inheritance and provides a master list of candidate mitophagy co-factors to validate in the future hypothesis-driven studies.
Ruminant Nutrition : Effects of a Mixture of Eugenol, Thymol and Malate on Growth Performance, Beef Quality and Liver Function in Hanwoo Finishing Steers Fed a High-Concentrate Diet (2010)

Thirty six Hanwoo steers (average BW, 564.5±25.7 kg; average age, approximately 23 months) were used to evaluate the effects of a mixture of eugenol(14%), thymol(1%) and malate (85%) on growth performance, beef quality and liver function in Hanwoo finishing steers fed ahigh-concentrate diet. A feeding trial was conducted for 7 months in National Agricultural Cooperative Federation farm located in Anseong, Korea. Steers were assigned randomly to one of three treatments: control (without additive supplementation), treatment 1(0.05% additive of concentrate), treatment 2(0.1% additive of concentrate). The results of this study showed that initial and final BW averaged 564 and 755 kg, respectively, and BW gain was significantly higher (P<0.05) for steers fed the additive mixture than for those fed no mixture (0.78 and 0.79 vs. 0.69 kg/d, respectively). Serum aspartate aminotransferase in the T2 treatment was decreased during the 24 to 31 months of age. Although supplementation of additives resulted in no substantial effect on carcass characteristics, it had a potential effect to improve feed efficiency and AST concentration in Hanwoo finishing steers fed a high-concentrate diet. In conclusion, a mixture of eugenol, thymol and malate has shown promise in improving feed efficiency and liver function in the finishing phase of Hanwoo steers.
Activity of hexokinase in mouse oocytes and preimplantation embryos (1989)

Conference Article| June 01 1989 Activity of hexokinase in mouse oocytes and preimplantation embryos MICHAEL A. K. HOOPER; MICHAEL A. K. HOOPER * Search for other works by this author on: This Site PubMed Google Scholar HENRY J. LEESE HENRY J. LEESE 1Department of Biology, University of York, Heslington, York YO1 5DD, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1989) 17 (3): 546–547. https://doi.org/10.1042/bst0170546 Article history Received: November 08 1988 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation MICHAEL A. K. HOOPER, HENRY J. LEESE; Activity of hexokinase in mouse oocytes and preimplantation embryos. Biochem Soc Trans 1 June 1989; 17 (3): 546–547. doi: https://doi.org/10.1042/bst0170546 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1989 Biochemical Society1989 Article PDF first page preview Close Modal You do not currently have access to this content.
Front Matter: Volume 6906 (2008)

This PDF file contains the front matter associated with SPIE Proceedings Volume 6906, including the Title Page, Copyright information, Table of Contents, Introduction (if any), and the Conference Committee listing.
Clocking Analysis, Implementation and Measurement Techniques for High-Speed Data Links—A Tutorial (2009)

The performance of high-speed wireline data links depend crucially on the quality and precision of their clocking infrastructure. For future applications, such as microprocessor systems that require terabytes/s of aggregate bandwidth, signaling system designers will have to become even more aware of detailed clock design tradeoffs in order to jointly optimize I/O power, bandwidth, reliability, silicon area and testability. The goal of this tutorial is to assist I/O circuit and system designers in developing intuitive and practical understanding of I/O clocking tradeoffs at all levels of the link hierarchy from the circuit-level implementation to system-level architecture.
No matter the order of monomer addition for the synthesis of well-defined block copolymers by sequential group transfer polymerization using N-heterocyclic carbenes as catalysts (2011)

Unsaturated N-heterocyclic carbenes (NHCs) such as 1,3-bis(di-isopropyl)imidazol-2-ylidene (1) and 1,3-bis(di-tert-butyl)imidazol-2-ylidene (2) are shown to catalyze the sequential group transfer polymerization (GTP) of (meth)acrylic monomers. A variety of block copolymers including not only alkyl methacrylate but also alkyl acrylate monomer units as well as blocks deriving from N,N-dimethylacrylamide and methacrylonitrile were thus obtained at room temperature, using 1-methoxy-2-methyl-1-trimethylsiloxypropene (MTS) as initiator in THF as solvent. Block copolymerizations could be achieved, starting indifferently from the GTP of the acrylic monomer to that of the methacrylic one or vice versa, that is, regardless of the order of addition of the two monomers, in contrast to most examples of block copolymer synthesis by “controlled/living” sequential polymerization. It is postulated that these NHC-catalyzed GTPs of (meth)acrylics proceed via a single step concerted-like associative mechanism, involving the formation of thermodynamically unstable intermediates or transition states, likely hypervalent siliconates, with no detectable anionic enolates formed.
Tofacitinib Has Induction Efficacy in Moderately to Severely Active Ulcerative Colitis, Regardless of Prior TNF Inhibitor Therapy (2016)

Introduction: Tofacitinib is an oral, small molecule JAK inhibitor that is being investigated for ulcerative colitis (UC). Two Phase 3 randomized placebo (PBO)-controlled studies (OCTAVE Induction 1 and 2: NCT01465763, NCT01458951) demonstrated efficacy of tofacitinib 10 mg twice daily (BID) vs PBO as induction therapy for patients (pts) with moderate to severe UC.1 Here, we assessed the effect of TNF inhibitor (TNFi) therapy and disease severity on clinical efficacy and patient-reported outcomes (PROs). Methods: Adults with moderately to severely active UC (Mayo score ≥6, rectal bleeding subscore ≥1 and endoscopic subscore ≥2) and prior failure/intolerance to ≥1 of corticosteroids, thiopurines or TNFi were randomized (4:1) to receive tofacitinib 10 mg or PBO BID for up to 9 weeks (wks). Efficacy endpoints at Wk 8 included: remission (Mayo score ≤2, no subscore >1 and rectal bleeding subscore of 0), mucosal healing at Wk 8 (Mayo endoscopic subscore ≤1), clinical response (decrease from baseline Mayo score of ≥3 points and ≥30%, plus decrease in rectal bleeding subscore ≥1 or absolute subscore ≤1). PROs at Wk 8 included IBDQ remission (total score ≥170) and IBDQ response (≥16-point increase from baseline). For binary endpoints, comparison of tofacitinib vs PBO was assessed using the Cochran-Mantel-Haenszel (CMH) chi-square test stratified by study, prior TNFi therapy, baseline corticosteroid use and geographic region. Within each subgroup, the CMH chi-square test stratified by study was used.Table 1: Summary of efficacy endpoints in OCTAVE Induction 1 and OCTAVE Induction 2 at Wk 8Results: Significantly more pts achieved remission, mucosal healing and clinical response at Wk 8 with tofacitinib 10 mg BID vs PBO (all p < 0.0001).The difference generally remained significant regardless of prior TNFi exposure, prior TNFi failure, primary or secondary TNFi failure or baseline Mayo score (≥9 or < 9). For all three endpoints, greater effects were observed when comparing secondary vs primary TNFi failure and baseline Mayo score < 9 vs ≥9 subpopulations. IBDQ remission and response were significantly greater with tofacitinib 10 mg BID vs PBO at Wk 8 regardless of prior TNFi exposure/prior TNFi failure. Conclusion: Tofacitinib 10 mg BID demonstrated efficacy vs PBO, regardless of prior TNFi therapy or baseline disease severity, in pts with moderately and severely active UC. PRO results were similar in pts with/without prior TNFi exposure or failure. Funded by Pfizer Inc. 1. Sandborn WJ et al. J Crohns Colitis 2016;10(S1):S15.
Chiral induzierte, mit einer Eliminierung gekoppelte Lithium-En-Reaktion – Synthese von (+)-(3R,4R)-1,2-Dihydromultifiden (1999)

Basierend auf der (−)-Spartein-induzierten asymmetrischen Deprotonierung gelingt die Cyclisierung des Alkadienylcarbamates 1 zum cis-Divinylcyclopentan 2 mit hoher Enantio- und Diastereoselektivität. Die Umsetzung läßt sich als Hybrid aus einer Lithium-En-Reaktion und einer SN′-Reaktion auffassen.
ChemInform Abstract: A Powerful o‐Quinone Dimethide Strategy for Intermolecular Diels—Alder Cycloadditions. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Role of Prostaglandin E in Receptor Activator of Nuclear Factor-.KAPPA.B Ligand (RANKL) Expression in Osteoblasts Induced by Cell Adhesion to Bone Marrow B-lymphocytes (2009)

Estrogen deficiency caused by ovariectomy (OVX) induces bone loss and increased B-lymphopoiesis in bone marrow. In OVX mice, the production of prostaglandin E (PGE) and the expression of receptor activator of nuclear factor-κB ligand (RANKL) were elevated in osteoblasts, and the cell adhesion of B cells induced RANKL expression in osteoblasts. However, the roles of PGE in RANKL expression and bone resorption are not clear. To examine the relationship between B-lymphopoiesis and PGE production by osteoblasts, B cells were purified from bone marrow, fixed, and co-cultured with mouse osteoblasts. Most of the fixed B cells adhered to cell surface of osteoblasts, and the cell-cell interaction markedly elevated the expression of cyclooxygenase (COX)-2 and membrane-bound PGE synthase (mPGES)-1 mRNAs, and PGE2 production in osteoblasts. Adding B cells also induced the expression of RANKL mRNA in osteoblasts, and the RANKL expression was suppressed by indomethacin, COX-2 inhibitor (NS398) and selective antagonist for PGE receptor EP4, suggesting that PGE production and EP4 signals are involved in RANKL-dependent bone resorption induced by cell-cell contact between B cells and osteoblasts. Therefore, the increased B-lymphopoiesis and PGE production by osteoblasts may contribute to the pathogenesis of osteoporosis due to estrogen deficiency.
Concise and Practical Synthesis of Latrunculin A by Ring‐Closing Enyne—Yne Metathesis. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Time Series Analyses of Diesel Exhaust Gas Emissions under Transient Operation. (1993)

Time series analyses of diesel exhaust gas emissions under transient operation were carried out using a gas sampling system to efficiently collect all exhaust gas over several cycles. The effects of fuel properties and other operating parameters on the exhaust emissions under transient runs were analyzed. The results showed that THC increased abruptly to 2-6 times the steady-state concentration immediately after the start of acceleration and then decreased to the steady-state values after 70-200 cycles. At acceleration, NOx increased abruptly to about 80% of the steady-state value, and then increased gradually to reach the steady-state values after 60-500 cycles. The behaviors of THC and NOx during transient operation can be described by the exponential functions of the elapsed cycle numbers and the final emission concentrations. The concentrations of CO, CO2, O2, and smoke changed abruptly to the steady-state values at the start of acceleration. One of the dominant factors affecting the gas emissions during transient operations is the deposition of fuel on the combustion chamber wall.
Follicular Dendritic Cells Specifically Express the Long CR2/CD21 Isoform (1997)

This paper describes an antibody (mAb 7D6) that specifically recognizes human follicular dendritic cells (FDCs). By expression cloning, a cDNA clone encoding for the long human CR2/ CD21 isoform (CD21L) that contains an additional exon (10a) was isolated. We demonstrated that FDCs selectively express CD21L, while B cells selectively express the short CR2/CD21 lacking exon 10a (CD21S). By screening mouse Ltk- cells transfected with the CD21L cDNA, we further showed that the other two anti-human FDC mAbs DRC-1 and KiM4 also recognize CD21L. Thus, CD21L represents the first characterized human FDC-specific molecule, which may confer unique functions of FDCs in germinal center development.
Antibody inhibition of suppressor cell induction. (1987)

The IJ genetic restrictions of suppressor T (Ts) cells are controlled by H-2-related determinants that are expressed on antigen-presenting cells. This has led to the hypothesis that Ts cells carry receptors for a self H-2-related ligand that is expressed on specialized antigen-presenting cells. We refer to this H-2-related ligand as the IJ interacting molecule. This report evaluates the ability of rabbit antibodies directed against idiotypes on monoclonal anti-IJ antibodies (the latter are presumably reactive with the Ts cell receptor) to bind IJ interacting molecule and to inhibit antigen presentation to Ts cells. Such anti-idiotypic reagents were prepared against T cell-reactive monoclonal anti-IJk and anti-IJd antibodies. The F(ab')2 fragments of these anti-idiotypic reagents blocked Ts cell induction. The inhibition was haplotype specific and mapped to the IJ region. The anti-idiotypic antibodies blocked the generation of Ts1, Ts2, and Ts3 cells. The cellular target of the blocking activity mediated by these anti-idiotypic antibodies is a macrophage. This was shown by using a cloned macrophage hybridoma line for both Ts induction and absorption of antibody activity. The combined data support the concept that macrophages express IJ interacting determinants that are responsible for Ts cell induction.
Doping engineering for front-end processing : symposium held March 25-27, 2008, San Francisco, California, U.S.A. (2008)

Materials scientists, silicon technologists and TCAD researchers come together in this book to share experimental results and physical models, discuss achievements and challenges, and identify key issues for future research in this field. The volume focuses on many aspects related to doping of semiconductors (Si, SiGe and Ge) for device fabrication, and explores areas for single-gate as well as multi-gate devices with planar and vertical architectures. Surface properties, coverage, bonding saturation and passivation, and annealing ambient are also discussed.
Model Studies Towards the Total Synthesis of the Anticancer Agent Roseophilin (2003)

In our new approach to the anticancer agent roseophilin (1), a concise, stereocontrolled synthesis of the bicyclic model system 16 was achieved. Key steps include a diastereoselective Ireland-Claisen rearrangement and a stereoselective construction of the hexahydro-cyclopenta[b]pyrrol-6-one core via a tandem intramolecular aza-Wittig/[3+2]-cycloaddition sequence.
Multi-Level Optical Flow Estimation Based On Spatial Partitioning (2021)

We address the problem of optical flow estimation between a stereo pair of images suitable for view interpolation applications. In recent years, deep learning based approaches are found to be capable of producing superior optical flow estimation results than that of traditional approaches. However, deep learning approaches generally suffer from large GPU memory constraints and hence their application is limited to low resolution images. Here, we present an approach to accurate optical flow estimation via the state-of-the-art deep learning based approaches that introduces fewer artifacts in view interpolation applications. We confirm the suitability of our approach through both qualitative and quantitative results.