gebhart/patrepeval huggingface dataset:
Deep Electron and Hole Traps in 6H-SiC Bulk Crystals Grown by the Halide Chemical Vapor Deposition (2006)

Deep electron and hole traps were studied in a series of high purity 6H-SiC single crystals grown by Halide Chemical Vapor Deposition (HCVD) method at various C/Si flow ratios and at temperatures between 2000 oC and 2100 oC. Characterization included Low Temperature Photoluminescence (LTPL), Deep Level Transient Spectroscopy (DLTS), Minority Carrier Transient Spectroscopy (MCTS), and Thermal Admittance Spectroscopy (TAS) measurements. Concentrations of all deep traps were shown to strongly decrease with increased C/Si flow ratio and with increased growth temperature. The results indicate that the majority of deep centers in 6H-SiC crystals grown by HCVD are due to native defects or complexes of native defects promoted by Si-rich growth conditions. The observed growth temperature dependence of residual donor concentration and traps density is explained by increasing the effective C/Si ratio at higher temperatures for the same nominal ratio of C and Si flows.
Research and Development of Ultra-Micro-Scale Centrifugal Compressor(Micro Gas Turbine and Micro Energy Conversion Systems,<Special Issue>Power and Energy System Symposium) (2009)

The loss generation factor of two-dimensional centrifugal compressors is investigated by CFD analysis. The main loss factor is the separated flow and main flow interaction, and wall friction in the impeller. According to these results, we modified the impeller blade design by changing the blade inlet and outlet angles. We also investigated the tip clearance effects by CFD analysis. It showed that the leakage flow and main flow interaction is one of the main loss factors. When the tip clearance is 7% of the blade height, the maximum adiabatic efficiency and pressure ratio deteriorated by about 10% and 0.12 points respectively in comparison to the no tip clearance. As a result, the maximum adiabatic efficiency of 64.7% was achieved.
Investigation of Sorption Behavior between Pyrene and Colloidal Organic Carbon from Activated Sludge Processes (2004)

The sorption behavior of pyrene for different size fractions of colloidal organic carbon (COC) originating from two biological wastewater treatment facilities (a full-scale activated sludge system (FSAS) and a membrane bioreactor (MBR)) was investigated by fluorescence quenching. Fluorescence lifetime measurements demonstrated a dynamic quenching component in all samples, including the colloidal-free filtrates. COC sorption coefficients (Kcoc) for pyrene ranged from <1 x 10(3) L/kgcoc to 80 x 10(3) L/kgcoc and were comparable to values obtained in the literature for natural organic matter. Both linear and nonlinear behaviors were observed in the Freundlich-described converted isotherms (n = 0.89-2.1). The aromatic content of COC was quantified by the molar extinction coefficient at 280 nm (e280). Good correlations were observed between COC-pyrene sorption coefficients and e280 coefficients, suggesting that e280 may be a useful tool for predicting colloidal transport of hydrophobic organic compounds (HOCs) from activated sludge systems. The removal of COC from treated effluents may appreciably reduce the concentrations of HOCs discharged to receiving streams.
Design and Implementation of a Network Aware Object-based Tape Device (2007)

Data storage requirements have constantly evolved over time. In recent times, the rate of increase in volume of data has been exponential, partly because of regulations and partly because of increase in richness of data. This trend has led to an equally explosive increase in cost of management. Intelligent storage devices built using object- based storage (OSD) interfaces have gained increased acceptance due to the benefits of reduced management costs. The command set of the current OSD standard does not work well with tape-based storage solutions. In this work we propose a few extensions to the OSD standard in order to facilitate easier integration of tape devices into the object storage ecosystem. Further, we propose an intelligent buffering mechanism to maximize the utility of network attached tape devices, and we also propose mechanisms to make tape cartridges more portable within any object storage ecosystem. Our results for the intelligent buffering mechanism show that our scheme adapts better to mismatches in network and tape drive bandwidths. Specifically, our scheme helps minimize the repositioning of the tape, leading to better utilization and increased lifetime of the tape.
Learning Light-Weight Edge-Deployable Privacy Models (2018)

Privacy becomes one of the important issues in data-driven applications. The advent of non-PC devices such as Internet-of-Things (IoT) devices for data-driven applications leads to needs for light-weight data anonymization. In this paper, we develop an anonymization framework that expedites model learning in parallel and generates deployable models for devices with low computing capability. We evaluate our framework with various settings such as different data schema and characteristics. Our results exhibit that our framework learns anonymization models up to 16 times faster than a sequential anonymization approach and that it preserves enough information in anonymized data for data-driven applications.
ChemInform Abstract: The Crystal Structure of a Novel Cyclotrisilicate: Cs8Nb10O23□( Si3O9)2. Its Relationship with the Pyrochlore and Benitoite Types. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Új pathomechanizmusok és kezelési lehetőségek vizsgálata a vese ischémia/reperfúziós károsodásában és krónikus allograft nephropathiában = Investigation of new pathomechanisms and treatment possibilities of renal ischemia/reperfusion injury and chronic allograft nephropathy (2011)

Eredményeink az erythropoietin (EPO) védő szerepét igazolták egyoldali vese ischemia/reperfúziós (I/R) károsodásban. Ez a védő szerep elsősorban hímekben igazolható. Hátterében az EPO HSP72-mediálta hatása állhat, amellyel a Na+/K+ ATP-áz funkciójának megtartását segíti elő. Vizsgálataink során az EPO sejt-protektív hatásának hátterében egy új szignál molekulát is sikerült azonosítanunk, a szérum és glükokortikoid aktiválta kináz-1-t (SGK1). Ezek az eredmények az EPO által kifejtett sejtprotekció hátterében álló új pathomechanizmusokat írtak le. Eredményeink alapján az EPO, illetve a leírt útvonalakra ható egyéb szerek további vizsgálata és klinikai hasznosítása jöhet szóba. Másik vizsgálatunk során az I/R-s károsodás kivédésében szerepet játszó mechanizmusok során megfigyelhető nemi különbségeket írtuk le. Igazoltuk, hogy hímekben elsősorban a HIF 1α, míg nőstényekben a HSF útvonal tűnik fontosabbnak. Végül igazoltuk. hogy az SGK1 anti-apoptotikus és sejtvédő funkciójában is nemi különbségek mutathatók ki I/R-t követően. Ezekkel az eredményeinkkel magyarázhatóak az irodalomban korábban leírt és egymásnak ellentmondó közlések, amelyek a tesztoszteron SGK1 reguláló hatását mutatták be. | Our results suggest that EPO protects against severe, unilateral renal I/R injury, especially in male rats. This beneficial effect might be partly the result of EPO’s HSP72-mediated impact on Na+/K+ATPase-α1. Moreover, our data report a new signaling molecule to be involved in EPO cytoprotective actions, since we identified for the first time an important role of SGK1 in the renoprotective effect of EPO. These observations provide insights into a novel signaling mechanism by which EPO partly exerts its potent tissue protective actions. Given our results along with previous reports, the clinical use of EPO possibly leading to reduced cellular damage due to ischemic events should be considered. Our study has revealed a gender-dependent protective mechanism during renal I/R injury. In males mostly the HIF 1α, while in females the HSF is the dominant transcriptional pathway. The EPO treatment results in disappearance of the characteristic signal pathway activation in both genders. The explanation for that could be either a direct negative feedback effect on the transcription factors or an indirect renal protective effect of EPO by which these transcriptional factors do not need to be activated. We could also demonstrate that the anti-apoptotic SGK1 shows a gender-specific expression pattern after renal I/R with higher levels in male rats. These results confirm previous contradictory reports showing that SGK1 might be up-regulated and activated by testosterone.
Biomimetic nanostructures in ZnS and ZnSe provide broadband anti-reflectivity (2017)

Graded-index, moth eye-inspired anti-reflective features were fabricated in ZnS and ZnSe via nanosphere lithography using a Langmuir–Blodgett dip-coating method with plasma-based mask reduction and pattern transfer. Arrays of hexagonally close-packed conical frusta (top diameter = 300 nm, pitch = 690 nm, height = 2800 nm) were realized by isotropic etching (size-reduction) of the colloidal mask with CF4/Ar, followed by pattern transfer into the substrate using CH4/H2 plasma etching. Substantial increases in broadband transmission were achieved across the 2–20 μm range, yielding 23% and 26% single-side transmission improvement, and 92% and 88% absolute double-side transmission for ZnS and ZnSe, respectively, in excellent agreement with finite difference time domain (FDTD) optical simulations. Experimental differences in direct versus total transmission, and the general fall off of transmission at short wavelengths, were attributed to diffuse forward scattering and diffractive effects, as predicted by far-field scattering patterns using FDTD. The fabrication method presented can be used to enhance efficiency for multiple IR applications by minimizing reflective losses, while offering the further advantages of scalability and low cost.
A proposed predictive mathematical model for efficient T-cell collection by leukapheresis for manufacturing chimeric antigen receptor T cells (2023)

Not available.
Velocity gradients in spatially resolved laser Doppler flowmetry and dynamic light scattering with confocal and coherence gating (2016)

Dynamic light scattering (DLS) is widely used to characterize diffusive motion to obtain precise information on colloidal suspensions by calculating the autocorrelation function of the signal from a heterodyne optical system. DLS can also be used to determine the flow velocity field in systems that exhibit mass transport by incorporating the effects of the deterministic motion of scatterers on the autocorrelation function, a technique commonly known as laser Doppler flowmetry. DLS measurements can be localized with confocal and coherence gating techniques such as confocal microscopy and optical coherence tomography, thereby enabling the determination of the spatially resolved velocity field in three dimensions. It has been thought that spatially resolved DLS can determine the axial velocity as well as the lateral speed in a single measurement. We demonstrate, however, that gradients in the axial velocity of scatterers exert a fundamental influence on the autocorrelation function even in well-behaved, nonturbulent flow. By obtaining the explicit functional relation between axial-velocity gradients and the autocorrelation function, we show that the velocity field and its derivatives are intimately related and their contributions cannot be separated. Therefore, a single DLS measurement cannot univocally determine the velocity field. Our extended theoretical model was found to be in good agreement with experimental measurements.
Fabrication and characterization of high damping electrostatic micro devices for vibration energy scavenging (2005)

ISBN:2-84813-057-1
ChemInform Abstract: Improved Syntheses of Substituted Carbazoles and Benzocarbazoles via Lithiation of the (Dialkylamino)methyl (Aminal) Derivatives. (1988)

Abstract The benzo‐fused N‐(pyrrolidinomethyl)pyrroles (I) and (VI) are selectively lithiated and then substituted with various electrophiles (II) to form the derivatives (III) or (VII) after deprotection.
Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder (2012)

Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder. Because of its multifactorial etiology, however, identifying the genes involved has been difficult. The authors followed up on recent findings suggesting that rare copy number variants (CNVs) may be important for ADHD etiology.; The authors performed a genome-wide analysis of large, rare CNVs (>1% population frequency) in children with ADHD (N=896) and comparison subjects (N=2,455) from the IMAGE II Consortium.; The authors observed 1,562 individually rare CNVs <100 kb in size, which segregated into 912 independent loci. Overall, the rate of rare CNVs <100 kb was 1.15 times higher in ADHD case subjects relative to comparison subjects, with duplications spanning known genes showing a 1.2-fold enrichment. In accordance with a previous study, rare CNVs <500 kb showed the greatest enrichment (1.28-fold). CNVs identified in ADHD case subjects were significantly enriched for loci implicated in autism and in schizophrenia. Duplications spanning the CHRNA7 gene at chromosome 15q13.3 were associated with ADHD in single-locus analysis. This finding was consistently replicated in an additional 2,242 ADHD case subjects and 8,552 comparison subjects from four independent cohorts from the United Kingdom, the United States, and Canada. Presence of the duplication at 15q13.3 appeared to be associated with comorbid conduct disorder.; These findings support the enrichment of large, rare CNVs in ADHD and implicate duplications at 15q13.3 as a novel risk factor for ADHD. With a frequency of 0.6% in the populations investigated and a relatively large effect size (odds ratio=2.22, 95% confidence interval=1.5–3.6), this locus could be an important contributor to ADHD etiology.
Modulation of liver injury by interleukin-10. (2003)

Inflammation is commonly observed in liver diseases and is frequently complicated by fibrosis and cirrhosis in end-stage disease. The only curative treatment for cirrhotic patients is liver transplantation. However, organ shortage as well as an increasing organ demand call for early treatment of liver disease and prevention of fibrosis. Experimental data have shown the critical role of pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in the development of liver injury. Here, we review our work on the role of endogenously produced interleukin-10 (IL-10), a potent anti-inflammatory cytokine, in several experimental models of acute and chronic liver injury. First, in acute macrophage-mediated hepatitis induced by galactosamine/lipopolysaccharide administration, IL-10 neutralisation led to a more severe liver damage, whereas IL-10 injection, even delayed, was able to limit liver necrosis. A similar protective effect of IL-10 was observed in acute T cell-mediated hepatitis induced by concanavalin A (Con A) injection. The immunoregulatory role of IL-10 was then established after repeated exposition to Con A. In carbon tetrachloride liver injury, two other properties of IL-10 have been suggested: modulation of hepatocyte proliferation and modulation of liver fibrosis. Finally, the potential therapeutic applications in human liver disease as well as the potential side effects are discussed.
Therapeutic bispecific antibody formats: a patent applications review (1994-2017) (2018)

Bispecific antibodies are progressively accepted as potentially superior therapeutic molecules in a broad range of diseases. This frantic activity creates a maze of hundreds of patents that pose considerable legal risks for both newcomers and established companies. It can consecutively be anticipated that the number of patent conflicts will increase. Nevertheless, it can be expected that patents related to the use of a bispecific antibody will have tremendous commercial value.
Design of a miniature ultrasound probe for 3D transesophageal echocardiography (2014)

The relatively large size of most of the current 3D Transesophageal Echocardiography probes (TEE) enables their usage in adults for short procedures only. In this paper, we propose a new miniature 3D TEE probe with a head volume of 1 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> , that would be suitable for use in neonates or for prolonged transnasal use in adults. We focus on partitioned designs, in which a minority of transmit elements is directly wired out and the majority of receive elements connect to a limited number of receive cables via an ASIC that performs a nine-fold data reduction in receive mode. The designs are motivated based on the pressure and beam width of the transmitted field, and the resolution, grating lobes and side lobes in the received field.
Pharmacokinetics, Trypanosoma brucei gambiense Efficacy, and Time of Drug Action of DB829, a Preclinical Candidate for Treatment of Second-Stage Human African Trypanosomiasis (2013)

Human African trypanosomiasis (HAT, also called sleeping sickness), a neglected tropical disease endemic to sub-Saharan Africa, is caused by the parasites Trypanosoma brucei gambiense and T. brucei rhodesiense. Current drugs against this disease have significant limitations, including toxicity, increasing resistance, and/or a complicated parenteral treatment regimen. DB829 is a novel aza-diamidine that demonstrated excellent efficacy in mice infected with T. b. rhodesiense or T. b. brucei parasites. The current study examined the pharmacokinetics, in vitro and in vivo activity against T. b. gambiense, and time of drug action of DB829 in comparison to pentamidine. DB829 showed outstanding in vivo efficacy in mice infected with parasites of T. b. gambiense strains, despite having higher in vitro 50% inhibitory concentrations (IC50s) than against T. b. rhodesiense strain STIB900. A single dose of DB829 administered intraperitoneally (5 mg/kg of body weight) cured all mice infected with different T. b. gambiense strains. No cross-resistance was observed between DB829 and pentamidine in T. b. gambiense strains isolated from melarsoprol-refractory patients. Compared to pentamidine, DB829 showed a greater systemic exposure when administered intraperitoneally, partially contributing to its improved efficacy. Isothermal microcalorimetry and in vivo time-to-kill studies revealed that DB829 is a slower-acting trypanocidal compound than pentamidine. A single dose of DB829 (20 mg/kg) administered intraperitoneally clears parasites from mouse blood within 2 to 5 days. In summary, DB829 is a promising preclinical candidate for the treatment of first- and second-stage HAT caused by both Trypanosoma brucei subspecies.
Supplementary Methods, Legends and Table 1 from Pericentromeric Instability and Spontaneous Emergence of Human Neoacrocentric and Minute Chromosomes in the Alternative Pathway of Telomere Lengthening (2023)

Supplementary Methods, Legends and Table 1 from Pericentromeric Instability and Spontaneous Emergence of Human Neoacrocentric and Minute Chromosomes in the Alternative Pathway of Telomere Lengthening
Reaction of neopentylidene complexes of the type M(CH-t-Bu)(N-2,6-C6H3-i-Pr2)(OR)2 (M = W, Mo) with methyl acrylate and N,N-dimethylacrylamide to give metallacyclobutane complexes (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of neopentylidene complexes of the type M(CH-t-Bu)(N-2,6-C6H3-i-Pr2)(OR)2 (M = W, Mo) with methyl acrylate and N,N-dimethylacrylamide to give metallacyclobutane complexesJerald Feldman, John S. Murdzek, William M. Davis, and Richard R. SchrockCite this: Organometallics 1989, 8, 9, 2260–2265Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://doi.org/10.1021/om00111a025RIGHTS & PERMISSIONSArticle Views470Altmetric-Citations81LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (820 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Synthesis of Ni(dvtms) and Ni(CO)3 Complexes Ligated by an Isolable Two‐Coordinate Cyclic Alkylsilylene (2020)

Ni(CO) 3 complexes ligated by an isolable cyclic (alkyl)(amino)silylene (CAASi) or an isolable cyclic dialkylsilylene (CDASi) were synthesized by the reaction of the corresponding Ni(dvtms) complex (dvtms = 1,1,3,3‐tetramethyl‐1,3‐divinyldisiloxane) with CO to estimate the donor strengths of CAASi and CDASi. The CO stretching frequencies (Tolman electronic parameters, TEP) of the Ni(CO) 3 complexes indicate that the net donating ability of CDASi and CAASi to Ni(CO) 3 are almost the same and in between PPh 3 and P( t Bu) 3 . The DFT calculations suggested that the TEP values are mainly correlated with the energy level of the lone pair orbital of the ligand but not strongly associated with those of the vacant π‐accepting orbitals.
Direct-Coupled DC-40 GHz Amplifier for High-Speed Data Communication System (2003)

The millimeter wave transport over fiber needs more and more bandwidth according to SONET norm which must be able to propagate baseband modulated digital signal. This paper presents a modulator driver which is a direct-coupled amplifier to overcome the frequency limitations due to the link capacitors. A two stages DC-40 GHz GaAs P-HEMT amplifier including a level shift cell has been designed using the real frequency synthesis method.
Spin-polarized scanning tunneling microscopy and spectroscopy study of c(2×2) reconstructed Cr(001) thin film surfaces (2006)

Spin dependent electronic properties of c(2×2) Cr(001) thin film surfaces grown on MgO(001) substrates are investigated by means of spin-polarized scanning tunneling microscopy and spectroscopy. An averaged dI∕dV spectrum obtained on the c(2×2) Cr(001) thin film surfaces exhibits a surface state around +0.1eV above the Fermi level. The intensity of the surface state peak in the spectra measured on (001) terraces is alternately varied whenever a monatomic step is crossed. Therefore, the shifted surface state as well as an original one on (1×1) Cr(001) surfaces has spin-polarized feature.