gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Stereoselective Reduction of Benzils: A New Convenient Route to Enantiomerically Pure 1,2‐Diarylethanediols. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Finite-element analysis of birefringence and dispersion properties in actual and idealized holey-fiber structures (2003)

Using a full-vector finite-element method, we calculate birefringence and dispersion in index-guiding photonic crystal fibers, also called holey fibers. Through real-model simulations the polarization-dependent dispersion in actual fiber structures is numerically demonstrated, for the first time to our knowledge. Furthermore the transverse-electric-field vector distributions in the fabricated holey fibers are also clarified for the two linearly polarized fundamental modes.
ReFlex (2016)

ReFlex is a flexible smartphone with bend input and active haptic feedback. ReFlex's features allow the introduction of sensations such as friction or resistance. We report results from an experiment using ReFlex in a targeting task, as well as initial users' reactions to the prototype. We explore both absolute and relative tactile haptic feedback, paired with two types of bend input mappings: position-control and rate-control. We observed that position-controlled cursors paired well with relative bend feedback, while rate-controlled cursors paired well with absolute bend feedback to indicate targets. We also explored an eyes-free condition. Results suggest that while eyes-free, haptic feedback conditions were more error-prone than visual-only conditions, the size of the error was relatively small, and users were able to complete the task in all cases. We present two application scenarios that take advantage of the unique input and output modalities of ReFlex and discuss its potential for within document navigation.
A comparative study of ultrasound and laser light diffraction techniques for particle size determination in dairy beverages (2006)

The particle size distribution (PSD) of milkfat droplets of raw and homogenized milk was determined by a diagnostic ultrasound technique that was initially calibrated with colloidal silica. The quality of the fit between ultrasound theory and experiment is discussed and provides a basis for comparison with the reference laser light scattering technique. The predicted ultrasonic attenuation was determined from the ECAH (Epstein P S and Carhart R R 1953 J. Acoust. Soc. Am. 25 553–65, Allegra J R and Hawley S A 1972 J. Acoust. Soc. Am. 51 1545–64) model using thermophysical data for milkfat and milk serum. New thermophysical properties of milkfat were established. The experimental data were obtained with the Ultrasizer spectrometer. Both techniques were affected by the milk proteins and could provide only qualitative milkfat PSD for the raw and the homogenized milk samples. Therefore, they showed their limitations to characterize multiple emulsions. However, preliminary results are shown for the ultrasound technique that account for the impact of the protein on the measured data and hence obtain quantitative results for the milkfat size distributions.
Guidelines for the use of flow cytometry and cell sorting in immunological studies * (2017)

Funding Information: Mairi Mc Grath and Regina Stark thank Francesco Siracusa and Patrick Maschmeyer for providing data and Klaas van Gisbergen for helpful discussions. Philip E. Boulais and Paul S. Frenette are grateful to Dr. Sandra Pinho for helpful comments and suggestions. They thank the National Institutes of Health for their support (R01 grants DK056638, HL116340, HL097819 to P.S.F). They also thank the New York State Department of Health (NYSTEM Program) for shared facility (C029154) and research support (N13G-262) and the Leukemia and Lymphoma Society’s Translational Research Program. Funding Information: Acknowledgements: Enrico Lugli and Pratip K. Chattopadhyay were supported by grants from the Fondazione Cariplo (Grant Ricerca Biomedica 2012/0683), the Italian Ministry of Health (Bando Giovani Ricercatori GR-2011-02347324) and the European Union Marie Curie Career Integration Grant 322093 (all to E.L.). E.L. and P.K.C. are International Society for the Advancement of Cytometry (ISAC) Marylou Ingram scholars. Alice Yue and Ryan R. Brinkman were funded by Genome BC and NSERC. Klaus Warnatz received funding from the German Federal Ministry of Education and Research (BMBF 01EO1303) and the Deutsche Forschungsgemeinschaft (DECIDE, DFG WA 1597/4-1 and the TRR130). The Jung laboratory is supported by funds of the ERC and ISF. Henrik Mei is a 2017-2021 ISAC scholar. Antonio Cosma is supported by the French government program: “Investissement d’avenir: Equipements d’Excellence” (EQUIPEX)-2010 FlowCyTech, Grant number: ANR-10-EQPX-02-01. Henrik Mei is supported by the Deutsche Forschungsgemeinschaft (DFG; grants Me3644/5-1 and TRR130/TP24). Funding Information: The Immunology Database and Analysis Portal (ImmPort) system provides an archive of immunology research data generated by investigators mainly funded through the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Division of Allergy, Immunology, and Transplantation (DAIT). It is an extensive data warehouse containing an integration of experimental and clinical trial data generated by dozens of assay types, including 63 flow cytometry and 5 CyTOF data sets. In addition, the ImmPort system also provides data analysis tools and it contains implicit knowledge and ‘‘best practices’’ for clinical and genomic studies in the form of nearly 50 templates for data deposition, management, and dissemination. ImmPort has been developed under the Bioinformatics Integration Support Contract (BISC) by the Northrop Grumman Information Technology Health
From GenderMag to InclusiveMag: An Inclusive Design Meta-Method (2019)

How can software practitioners assess whether their software supports diverse users? Although there are empirical processes that can be used to find “inclusivity bugs” piecemeal, what is often needed is a systematic inspection method to assess software's support for diverse populations. To help fill this gap, this paper introduces InclusiveMag, a generalization of GenderMag that can be used to generate systematic inclusiveness methods for a particular dimension of diversity. We then present a multicase study covering eight diversity dimensions, of eight teams' experiences applying InclusiveMag to eight under-served populations and their “mainstream” counterparts.
Observation of the Ξb−→J/ψΛK− decay (2017)

The observation of the decay - b J /K -is reported, using a data sample corresponding to an integrated luminosity of 3 fb -1 , collected by the LHCb detector in pp collisions at centre-of-mass energies of 7 and 8 TeV. The production rate of - b baryons detected in the decay - b J /K -is measured relative to that of 0 b baryons using the decay 0 b J /. Integrated over the b-baryon transverse momentum p T < 25 GeV/c and rapidity 2.0 < y < 4.5, the measured ratio is
Minimizing the Barite Scale in Carbonate Formations during the Filter Cake Removal Process (2022)

The barite scale is one of the most common scales in the oil and gas industry. It can form in the reservoir or precipitate in different production equipment. The formation of such a scale will significantly minimize the capillary diameter of the flow channels and consequently shrink the well productivity. On the other hand, the production of movable barite particles causes severe erosion for the installed equipment. There are several sources of the barite scale such as mixing of incompatible brines and solid invasion of the barite weighted during drilling. In addition, the barite scale could be produced during the interaction of the chelating agent solutions with the reservoir formation during the filter cake removal process (secondary damage). The main focus of this study is to prevent the barite scale inside the carbonate formations during filter cake removal. The capability of a solution consisting of both diethylenetriamine pentaacetic acid (DTPA) and ethylenediamine tetraacetic acid (EDTA) as a novel solution to prevent barite scale formation in carbonate formations after the removal of the barite filter cake was evaluated. A series of laboratory experiments were accomplished to characterize the barite scale and evaluate the performance of the proposed solution. In particular, particle size distribution, scanning electron microscopy, X-ray diffraction, core flooding, NMR spectroscopy, solubility test, and inductively coupled plasma (ICP) spectroscopy tests were conducted for this aim. The experiments were performed using carbonate core samples. The results showed that the proposed solution was able to load 35 000 ppm barium in the presence of calcite ions. The addition of EDTA tended to inhibit the barite deposition and improve the rate of the calcite reaction. NMR results showed that a mixture of DTPA and EDTA (20%) can stimulate the macropores, resulting in an increase in the return permeability by 1.4-1.8 times of the initial value, while the precipitation that occurred in the micropores could be ignored with respect to the overall porosity improvements.
Machine‐to‐machine communication with long‐term evolution with reduced device energy consumption (2013)

ABSTRACT We present a method to reduce the device battery consumption to efficiently support battery‐operated machine‐to‐machine (M2M) communication in 3GPP long‐term evolution. The long‐term evolution discontinuous reception (DRX) is a key mechanism in reducing the device energy consumption, and we discuss how the traffic behaviour of machines in the Internet of things scenarios differs from the typical cellular user of today, for whom the current DRX mechanism is optimised for. We list typical transactions in M2M scenarios and discuss how the DRX operation is affected. We continue by introducing a power consumption model for M2M devices. Our assumption is that the device transmits small amounts of data in the uplink with deterministic intervals. The model takes into account the energy consumption in the active and the nonactive periods of the communication, which alternate depending on the DRX configuration. We use the model with different parameter settings referring to potential future M2M devices and identify the parameters, which contribute most to the device energy consumption. The results indicate that making the current maximum DRX cycle length longer will lead to significant gains in the energy consumption of M2M devices compared with what is possible today. Our key contributions include the discussion of the DRX mechanism in the Internet of things scenarios and the realistic assumptions for the potential of trading the responsiveness of a device for energy consumption gain with very long DRX cycles. Copyright © 2013 John Wiley &amp; Sons, Ltd.
TAMI-29. MULTIFACTORIAL UPREGULATION OF ID1 DRIVES DIPG INVASIVENESS AND IS THERAPEUTICALLY TARGETABLE (2020)

Abstract Diffuse intrinsic pontine gliomas (DIPGs) are lethal brain tumors with no effective therapies other than radiation. Inhibitor of DNA binding (ID) proteins, key regulators of lineage commitment during embryogenesis, are implicated in tumorigenesis in multiple human cancers. Prior work showed that recurrent H3F3A and ACVR1 mutations increase ID1 expression in cultured astrocytes. However, this has not been validated in human DIPG. The regulation and targetability of ID1 in DIPG has not been explored either. Exome and transcriptome sequencing analysis of multi-focal DIPG tumors and normal brain tissue from autopsy (n=52) revealed that ID1 expression is significantly elevated in DIPG tissues. Higher ID1 expression correlates with reduced survival in DIPG patients and increased regional invasion in multi-focal autopsy samples. Analyses of developing mouse brain RNA/ChiP-Seq data revealed high ID1 expression and H3K27ac promoter binding in prenatal hind brain compared to all other prenatal and postnatal brain regions. ChIP-qPCR for H3K27ac and H3K27me3 revealed that ID1 gene regulatory regions are epigenetically poised for upregulation in DIPG tissues compared to normal brain, regardless of H3/ACVR1 mutational status. These data support that the developing pons is regionally poised for ID1 activation. Genetic (shRNA) ID1 knockdown in primary human H3.3K27M-DIPG cells (DIPG007) resulted in significantly reduced invasion and migration in vitro. Additionally, DIPG-ID1-KO cells showed improved sensitivity to radiation therapy. Phospho-kinase array analysis of DIPG cells revealed that Akt and WNK1 activity were significantly downregulated upon ID1 knockdown, which was previously shown in lung tumors. Treatment of DIPG007 cells with cannabidiol (CBD) reduced ID1 expression levels and viability/proliferation of DIPG cells in vitro. ID1 knockdown and CBD treatment studies in vivo are ongoing. In summary, our findings indicate that multifactorial (genetic and regional) epigenetic upregulation of ID1 drives DIPG invasiveness and targeting ID1 using CBD may be a potential strategy for the treatment of DIPGs.
Joint modelling of longitudinal and repeated time-to-event data using nonlinear mixed-effects models and the stochastic approximation expectation–maximization algorithm (2014)

International audience
Energy–delay tradeoffs in combinational logic using gate sizing and supply voltage optimization (2002)

This paper relates the potential energy savings to the energy profile of a circuit. These savings are obtained by using gate sizing and supply voltage optimization to minimize energy consumption subject to a delay constraint. The sensitivity of energy to delay is derived from a linear delay model extended to multiple supplies. The optimizations are applied to a range of examples that span typical circuit topologies including inverter chains, SRAM decoders and adders. At a delay of 20% larger than the minimum, energy savings of 40% to 70% are possible, indicating that achieving peak performance is expensive in terms of energy.
Erratum: “High-quality InAsyP1−y step-graded buffer by molecular-beam epitaxy” [Appl. Phys. Lett. 82, 3212 (2003)] (2003)

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Chemically Bonded Ceramics Based on Ca-Aluminates as Biomaterials (2008)

This presentation aims at giving an overview picture of the potential of Ca-aluminate as biomaterial. Identified possible applications for Ca-aluminate based materials are within vertebroplasty and odontology. An additional field of interest is as an implant coating material. Ca-aluminate with oxide particles as well as Ca-aluminate with glass particles were examined concerning handling and mechanical properties, biocompatibility and bioactivity. For both orthopaedic and dental injectable CA-pastes the working time of 4 minutes and the setting time about 10 minutes are achievable. The fracture toughness was determined to be in the range 0.5-1.0 MPam 1,2 and the compressive strength in the interval 150-250 MPa depending on selected w/c ratio, and the flexural strength above 50 MPa. The hardness is about 100 HV, and Young's modulus 10-15 GPa. The hydrates formed are in the size range of 20-50 nm. In hard tissue the Ca-aluminate based materials form a chemical interface totally closing the gap between the biomaterial and the surrounding tissue. Two features contribute to this sealing of interfaces; first the general dissolution of Ca-aluminate and precipitation of nanosize hydrates in micro-voids between particles and tissue, and on all possible walls including tissue surfaces, and second the zone formation including possible apatite formation upon which bioactive-induced formation of new tissue including apatite formation. Thus both a pure chemical integration and a biologically induced integration contribute to sealing of biomaterial-tissue interfaces.
Mid-regional pro-atrial natriuretic peptide is a strong predictor of outcome in an unselected cohort of critically ill patients (2007)

Atrial natriuretic peptide (ANP) is a strong predictor of outcome in patients with heart failure, various other cardiovascular diseases and in patients with systemic inflammatory response syndrome and sepsis. Furthermore, ANP is elevated in patients with kidney disease. We aimed to test the prognostic potency of the precursor molecule mid-regional pro-atrial natriu-retic peptide (MR-pro-ANP) in an unselected cohort of critically ill patients.
The giving back (2015)

From the Combat Casualty Care Research Program (T.E.R., D.G.B.), Department of Defense, Fort Detrick, Frederick; and The Uniformed Services University of the Health Sciences (T.E.R., C.G.), Bethesda, Maryland. The views expressed in this report are those of the authors and do not reflect official positions or policies of the United States Air Force or Department of Defense. Address for reprints: Todd Erik Rasmussen, MD, Combat Casualty Care Research Program, Department of Defense, 722 Doughten St, Room 1, Fort Detrick, Frederick, MD; email: [email protected].
Extension of the boundary element method to systems with conductors and piece-wise constant dielectrics (1996)

Accurate modeling of electric fields is necessary to study the dynamics of microelectromechanical systems (MEMS). Typical microelectromechanical systems use high dielectric-constant materials, however, which significantly affect the electric field. Many numerical packages use the finite element method (FEM) to deal with systems with dielectrics. The FEM is not, however, very efficient in modeling microelectromechanical systems. There exist numerical packages that use the boundary element method (BEM), which is more desirable due to its low computational cost. But the BEM as it exists cannot model the effects of the dielectrics. This paper extends the BEM to systems with piece-wise constant dielectrics as well as conductors.
Flexible low-voltage high-frequency organic thin-film transistors (2020)

The primary driver for the development of organic thin-film transistors (TFTs) over the past few decades has been the prospect of electronics applications on unconventional substrates requiring low-temperature processing. A key requirement for many such applications is high-frequency switching or amplification at the low operating voltages provided by lithium-ion batteries (~3 V). To date, however, most organic-TFT technologies show limited dynamic performance unless high operating voltages are applied to mitigate high contact resistances and large parasitic capacitances. Here, we present flexible low-voltage organic TFTs with record static and dynamic performance, including contact resistance as small as 10 Ω·cm, on/off current ratios as large as 10<sup>10</sup>, subthreshold swing as small as 59 mV/decade, signal delays below 80 ns in inverters and ring oscillators, and transit frequencies as high as 21 MHz, all while using an inverted coplanar TFT structure that can be readily adapted to industry-standard lithographic techniques.
Using TCAD, Response Surface Model and Monte Carlo Methods to Model Processes and Reduce Device Variation (2009)

Reduction of electrical parameter variation is essential to achieve high yield and reliability in semiconductor devices. However, variation depends on a large number of process factors, which are often interdependent. In this work, well-calibrated Technology Computer-Aided-Design process and device simulations were performed in a designed experiment to develop an efficient, surrogate response surface model (RSM) of the device parameters as a function of key process factors. Monte Carlo simulations were performed with the RSM to estimate variation and design systems to reduce variation. The approach, illustrated here specifically for peripheral n-type field-effect transistors in a dynamic random-access-memory process flow, is general, easy-to-implement, and a cost-effective way to systematically identify, model, and analyze process variation.
Gate tunneling current in In/sub 0.53/Ga/sub 0.47/As junction field-effect transistors (2003)

Data are presented which conclusively eliminate channel current impact ionization as the dominant source of gate leakage current in InGaAs JFETs based on both the temperature and channel current dependence. At the same time, strong evidence is presented which indicates that band-to-band tunneling at the gate-drain interface is the dominant source of gate leakage current. Based on these and previous results, it is concluded that InGaAs JFETs in linear preamplifiers such as optical receivers have an optimum channel doping of approximately 9*10/sup 16/ cm/sup -3/ at a bandwidth of 1 GHz. This value is obtained based on a tradeoff between gain, bandwidth, and noise.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A new synthesis of pyrroles (2002)

The radical reaction between an N-ethylsulfonylenamide and an alpha-xanthyl ketone gives an intermediate gamma-keto imine which spontaneously ring-closes to the pyrrole.
Array-based comparative genomic hybridization (CGH) identifies chromosomal imbalances between Interleukin-2 complete and non-responders (2008)

5043 Background: IL-2 is the only FDA approved treatment for metastatic renal cell cancer capable of producing durable complete responses (CR). However, it is associated with toxicity and a low CR rate. We used array-based CGH to detect a chromosomal profile that distinguishes between IL-2 responders and non-responders. Methods: 10-μm paraffin-embedded tumour sections were cut from 16 RCC patients (5 CRs and 11 Non-Responders (NRs)), tumor areas with >90% clear cell RCC were microdissected, and DNA extracted using phenol/chloroform. Labeled tumor and reference DNAs were applied to Human array 2.0 CGH arrays in triplicate. Fluorescence images were collected using a CCD camera, and analyzed with Spot 2.0 software. For each clone, an average single log2 ratio of test over reference intensity was calculated from replicate spots. The frequency of gains and losses for a given clone was calculated as the proportion of samples in which a clone was gained or lost in that group. Clones with significantly different copy number between different groups were compared using Fisher’s Exact Test. Results: CRs showed fewer whole chromosome changes, more genomic gains, and fewer genomic losses than NRs, who were distinguished by loss of chromosomes 4, 9, and 17p. Of CRs, there was 0% loss of 9p clones, compared to 65% of NRs and 90% of lymph node positive NRs (p<0.001). On 9p, frequently involved regions of loss in NR subjects included 9p13, 9p21, and 9p24 on which CAIX, p16 and S6, and B7H1 genes are located, respectively. In a separate analysis of 282 RCC patients using standard cytogenetics, loss of 4p and 9p were associated with worse survival, and 3 IL-2 responders analyzed had no loss on either 4p or 9p. Conclusions: Patterns of chromosomal imbalance are significantly different in IL-2 Complete and Non-Responders. Loss of chromosome 4, 9, and 17p may identify alterations that can serve as predictors of IL-2 non-response. Further investigation of genes located on these regions may lead to better understanding of the molecular biology of RCC and IL-2 response. If prospectively validated, CGH analysis of genetic alterations may aid clinicians in targeted selection of appropriate treatment options. Funding: NIH K23CA095151–01; NCI P50CA101942 No significant financial relationships to disclose.
Dynamic Walking in Leg Robots with Two Joint Simultaneous Drive Mechanismkicking Force Control (2016)

Dynamic Walking is one of human walking method performs kicking continuously,thereby realizing stable walking.This paper presents the dynamic output control of stable kicking force required to walk,also bi-articular simultaneous drive mechanism the relationship between the liveing body muscle to print it out using a simple conpass model.