gebhart/patrepeval huggingface dataset:
Comparison of process estimation techniques for on-line calibration monitoring (2006)

The goal of on-line calibration monitoring is to reduce the number of unnecessary calibrations performed each refueling cycle on pressure, level, and flow transmitters in nuclear power plants. The effort requires a baseline for determining calibration drift and thereby the need for a calibration. There are two ways to establish the baseline: averaging and modeling. Averaging techniques have proven to be highly successful in the applications when there are a large number of redundant transmitters; but, for systems with little or no redundancy, averaging methods are not always reliable. That is, for non-redundant transmitters, more sophisticated process estimation techniques are needed to augment or replace the averaging techniques. This paper explores three well-known process estimation techniques; namely Independent Component Analysis (ICA), Auto-Associative Neural Networks (AANN), and Auto-Associative Kernel Regression (AAKR). Using experience and data from an operating nuclear plant, the paper will present an evaluation of the effectiveness of these methods in detecting transmitter drift in actual plant conditions. (authors)
Antisense oligonucleotide‐mediated knockdown ofMpzl3attenuates the negative metabolic effects of diet‐induced obesity in mice (2021)

Previously, we demonstrated that global knockout (KO) of the gene encoding myelin protein zero-like 3 (Mpzl3) results in reduced body weight and adiposity, increased energy expenditure, and reduced hepatic lipid synthesis in mice. These mice also exhibit cyclic and progressive alopecia which may contribute to the observed hypermetabolic phenotype. The goal of the current study was to determine if acute and peripherally restricted knockdown of Mpzl3 could ameliorate the negative metabolic effects of exposure to a high-fat and sucrose, energy-dense (HED) diet similar to what was observed in global Mpzl3 KO mice in the absence of a skin phenotype. Mpzl3 antisense oligonucleotide (ASO) administration dose-dependently decreased fat mass and circulating lipids in HED-fed C57BL/6N mice. These changes were accompanied by a decrease in respiratory exchange ratio, a reduction in energy expenditure and food intake, a decrease in expression of genes regulating de novo lipogenesis in white adipose tissue, and an upregulation of genes associated with steroid hormone biosynthesis in liver, thermogenesis in brown adipose tissue and fatty acid transport in skeletal muscle. These data demonstrate that resistance to the negative metabolic effects of HED is a direct effect of Mpzl3 knockdown, rather than compensatory changes that could be associated with deletion of Mpzl3 during development in global KO mice. Inhibiting MPZL3 could be a potential therapeutic approach for the treatment of obesity and associated dyslipidemia.
Deficits in Female Reproductive Function in GH-R-KO Mice; Role of IGF-I (1999)

Mice homozygous for targeted disruption of the GH receptor/GH binding protein gene (GH-R-KO mice; -/-) exhibit reduced plasma IGF-I levels, elevated plasma GH levels, and dwarf phenotype. Although most GH-R-KO mice are fertile, age at first conception is greatly delayed in -/- x -/- matings. Here we report that the age of vaginal opening is significantly delayed in GH-R-KO vs. normal mice, but it can be advanced by treatment with recombinant human (rh)IGF-I. In pregnant GH-R-KO females, fetal size is reduced and pregnancy is prolonged while placental weight is, unexpectedly, increased. Alterations in fetal and placental weight are related to maternal rather than fetal genotype. Moreover, litter size and body weight of newborn pups are significantly reduced in GH-R-KO vs. normal females. Reduction in litter size reflects both dam and sire effects. We conclude that GH resistance and consequent reduction in peripheral IGF-I levels is associated with delay of female puberty, alterations in fetal and placental growth, delay of parturition, and reduced litter size.
HTLV: epidemiology and relationship to disease. (1984)

With the discovery of the human retrovirus class, an important turning point in the understanding of the process by which cancer is caused and develops in humans has been achieved. As summarized here, clinical and epidemiologic studies have documented the close association of human T-cell leukemia virus (HTLV-I) to a particular form of T-cell malignancy, adult T-cell leukemia/lymphoma (ATL). Yet to be understood is the process involved in translating virus infection into malignant lymphoproliferation. Epidemiologic data suggest that this may involve a relatively long latent period between primary HTLV-I infection and subsequent malignancy risk. Presumably, identifiable co-factors will emerge to explain the trigger for malignant transformation. However, the restricted pattern of tumor phenotype suggest that this process is tightly linked to cells for which HTLV-I has a particularly strong infectious trophism. Interdisciplinary studies are currently under way in a number of laboratories to elucidate the molecular interactions in the HTLV-I associated malignant transformation process in order to correlate these with the epidemiologic data. Thus, lessons are likely to be learned from these molecular and epidemiologic studies which may provide new and important etiologic insights applicable to the prevention and therapy of cancer. Furthermore, with the recent discovery of HTLV-III, a cytopathic form of this class of human retrovirus, the likely cause of acquired immunodeficiency syndrome (AIDS) has been discovered. This has enormous public health implications for the detection, treatment, and prevention of this major medical epidemic. Epidemiologic studies are currently under way to identify what factors associated with virus exposure result in the full-blown AIDS syndrome. In addition, the malignancy potential of this new type of retrovirus is currently the subject of intensive investigation.
Radiated EMI Prediction in Power Converters with Power Cables Based on Cable Antenna Voltage Gain Extraction (2022)

Radiated Electromagnetic interference (EMI) issue becomes more and more important in power electronics systems in recent years. To fully understand the generation and propagation mechanism of the radiated EMI, radiated EMI modeling and prediction techniques are very important. In this article, an active-clamp Flyback converter with long power cables is taken as an example, the radiated EMI model is developed, a step-by-step guide to predict the radiated EMI spectrum is proposed, some important issues are pointed out for EMI prediction. The predicted EMI based on the proposed guide can match the measured EMI very well within 6dB error in the range of 30MHz − 230MHz based on EN55032 3m class B standard.
Fair and QoS-oriented resource management in heterogeneous networks (2013)

In this paper, a heterogeneous network composed of femtocells deployed within a macrocell network is considered, and a quality-of-service (QoS)-oriented fairness metric which captures important characteristics of tiered network architectures is proposed. Using homogeneous Poisson processes, the sum capacities in such networks are expressed in closed form for co-channel, dedicated channel, and hybrid resource allocation methods. Then a resource splitting strategy that simultaneously considers capacity maximization, fairness constraints, and QoS constraints is proposed. Detailed computer simulations utilizing 3GPP simulation assumptions show that a hybrid allocation strategy with a well-designed resource split ratio enjoys the best cell-edge user performance, with minimal degradation in the sum throughput of macrocell users when compared with that of co-channel operation.
Decouple-and-Sample: Protecting sensitive information in task agnostic data release (2022)

We propose sanitizer, a framework for secure and task-agnostic data release. While releasing datasets continues to make a big impact in various applications of computer vision, its impact is mostly realized when data sharing is not inhibited by privacy concerns. We alleviate these concerns by sanitizing datasets in a two-stage process. First, we introduce a global decoupling stage for decomposing raw data into sensitive and non-sensitive latent representations. Secondly, we design a local sampling stage to synthetically generate sensitive information with differential privacy and merge it with non-sensitive latent features to create a useful representation while preserving the privacy. This newly formed latent information is a task-agnostic representation of the original dataset with anonymized sensitive information. While most algorithms sanitize data in a task-dependent manner, a few task-agnostic sanitization techniques sanitize data by censoring sensitive information. In this work, we show that a better privacy-utility trade-off is achieved if sensitive information can be synthesized privately. We validate the effectiveness of the sanitizer by outperforming state-of-the-art baselines on the existing benchmark tasks and demonstrating tasks that are not possible using existing techniques.
Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos (2019)

Mitochondria provide the major source of ATP for mammalian oocyte maturation and early embryo development. Oxygen Consumption Rate (OCR) is an established measure of mitochondrial function. OCR by mammalian oocytes and embryos has generally been restricted to overall uptake and detailed understanding of the components of OCR dedicated to specific molecular events remains lacking. Here, extracellular flux analysis (EFA) was applied to small groups of bovine, equine, mouse and human oocytes and bovine early embryos to measure OCR and its components. Using EFA, we report the changes in mitochondrial activity during the processes of oocyte maturation, fertilisation, and pre-implantation development to blastocyst stage in response to physiological demands in mammalian embryos. Crucially, we describe the real time partitioning of overall OCR to spare capacity, proton leak, non-mitochondrial and coupled respiration - showing that while activity changes over the course of development in response to physiological demand, the overall efficiency is unchanged. EFA is shown to be able to measure mitochondrial function in small groups of mammalian oocytes and embryos in a manner which is robust, rapid and easy to use. EFA is non-invasive and allows real-time determination of the impact of compounds on OCR, facilitating an assessment of the components of mitochondrial activity. This provides proof-of-concept for EFA as an accessible system with which to study mammalian oocyte and embryo metabolism.
ChemInform Abstract: First Total Synthesis of Bengazole A. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Scenario-Transferable Semantic Graph Reasoning for Interaction-Aware Probabilistic Prediction (2022)

Accurately predicting the possible behaviors of traffic participants is an essential capability for autonomous vehicles. Since autonomous vehicles need to navigate in dynamically changing environments, they are expected to make accurate predictions regardless of where they are and what driving circumstances they encountered. Several methodologies have been proposed to solve prediction problems under different traffic situations. These works usually combine agent trajectories with either color-coded or vectorized high definition (HD) map as input representations and encode this information for behavior prediction tasks. However, not all the information is relevant in the scene for the forecasting and such irrelevant information may be even distracting to the forecasting in certain situations. Therefore, in this paper, we propose a novel generic representation for various driving environments by taking the advantage of semantics and domain knowledge. Using semantics enables situations to be modeled in a uniform way and applying domain knowledge filters out unrelated elements to target vehicle’s future behaviors. We then propose a general semantic behavior prediction framework to effectively utilize these representations by formulating them into spatial-temporal semantic graphs and reasoning internal relations among these graphs. We theoretically and empirically validate the proposed framework under highly interactive and complex scenarios, demonstrating that our method not only achieves state-of-the-art performance, but also processes desirable zero-shot transferability.
Application of imprint technologies for creation of micro- and nanoscale pattern (2004)

Nanoimprinting is a low cost method to fabricate features from &#956;m down to the nm-range. Different nanofabrication techniques, namely hot embossing, UV-nanoimprinting as well as micro-contact printing will be discussed. Recently achieved results with nanoimprinting methods will be demonstrated.
ChemInform Abstract: Synthesis, Structure, and Reactions of (1‐Ethoxyethyl)zirconocene Chloride, a Stable Acyclic Secondary Zirconocene Alkyl. (1989)

Abstract The title compound (III), a 18‐electron complex with a η2‐ethoxyethyl ligand, is prepared according to the scheme and characterized by X‐ray structure analysis (space group P2 1 /n, Z=4).
ChemInform Abstract: 6‐Phenyl‐1,4‐dihydropyridine Derivatives as Potent and Selective A3 Adenosine Receptor Antagonists. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Adaptive microphone array with noise statistics updates (2004)

In this paper, we present a new subband adaptive beamformer equipped with noise statistics updates. These updates are employed to effectively estimate and track the noise statistics continuously in the solution. Additionally, an update on the source power spectral density (PSD) is incorporated to enhance the timbre of the source of interest. Furthermore, the beamformer is also equipped with a space constraint on the source area to provide robustness against steering vector errors and good capture of the target signal spatially. The entire processing can be viewed as an efficient combination of weighted spatial and temporal filters. Evaluations on real car data with variations in the car noise level show that the proposed scheme achieves a good noise suppression level up to 20 dB.
Composition and Enantiomeric Analysis of the Essential Oil of the Fruits and the Leaves of Pistacia vera from Greece (2007)

The essential oils of the fruits and the leaves of pistachio (Pistacia vera L.) were analyzed by GC and GC/MS. Fresh unripe pistachio fruits were richer in essential oil (0.5%, w/w) than the leaves (0.1%, w/w). Twenty one compounds were identified in the essential oil of the fruits and the major components were (+)-alpha-pinene (54.6%) and terpinolene (31.2%). The enantiomeric ratio of the major constituents of the essential oil of the fruits was determined using chiral GC/MS and it was found that the (+)/(-)-alpha-pinene ratio was 99.5:0.5, (+)/(-)-limonene 80:20, (+)/(-)-beta-pinene 96:4, and (+)/(-)-alpha-terpineol 0:100. Thirty three compounds were identified in the essential oil of the leaves and the major components were found to be alpha-pinene (30.0%), terpinolene (17.6%) and bornyl acetate (11.3%).
Speeding up X.509 Certificate Path Validation (2005)

A fast algorithm to execute path validation of the X.509 Certificate was developed. The algorithm used not only certificates and certificate revocation information but also certification path information as cached information in order to speed up transactions. The effect of it was confirmed by the experiment of the server system that had the fast algorithm of certification path validation under the private test environment.
Discovery of Small Molecule Inhibitors that Interact with γ‐Tubulin (2012)

Recent studies have shown an overexpression of γ-tubulin in human glioblastomas and glioblastoma cell lines. As the 2-year survival rate for glioblastoma is very poor, potential benefit exists for discovering novel chemotherapeutic agents that can inhibit γ-tubulin, which is known to form a ring complex that acts as a microtubule nucleation center. We present experimental evidence that colchicine and combretastatin A-4 bind to γ-tubulin, which are to our knowledge the first drug-like compounds known to interact with γ-tubulin. Molecular dynamics simulations and docking studies were used to analyze the hypothesized γ-tubulin binding domain of these compounds. The suitability of the potential binding modes was evaluated and suggests the subsequent rational design of novel targeted inhibitors of γ-tubulin.
Data from Genomic Profiling of Metastatic Uveal Melanoma and Clinical Results of a Phase I Study of the Protein Kinase C Inhibitor AEB071 (2023)

&lt;div&gt;Abstract&lt;p&gt;Up to 50% of patients with uveal melanoma (UM) develop metastatic disease, for which there is no effective systemic treatment. This study aimed to evaluate the safety and efficacy of the orally available protein kinase C inhibitor, AEB071, in patients with metastatic UM, and to perform genomic profiling of metastatic tumor samples, with the aim to propose combination therapies. Patients with metastatic UM (&lt;i&gt;n&lt;/i&gt; = 153) were treated with AEB071 in a phase I, single-arm study. Patients received total daily doses of AEB071 ranging from 450 to 1,400 mg. First-cycle dose-limiting toxicities were observed in 13 patients (13%). These were most commonly gastrointestinal system toxicities and were dose related, occurring at doses ≥700 mg/day. Preliminary clinical activity was observed, with 3% of patients achieving a partial response and 50% with stable disease (median duration 15 weeks). High-depth, targeted next-generation DNA sequencing was performed on 89 metastatic tumor biopsy samples. Mutations previously identified in UM were observed, including mutations in &lt;i&gt;GNAQ, GNA11, BAP1, SF3B1, PLCB4&lt;/i&gt;, and amplification of chromosome arm 8q. &lt;i&gt;GNAQ&lt;/i&gt;/&lt;i&gt;GNA11&lt;/i&gt; mutations were observed at a similar frequency (93%) as previously reported, confirming a therapeutic window for inhibition of the downstream effector PKC in metastatic UM.&lt;/p&gt;&lt;p&gt;In conclusion, the protein kinase C inhibitor AEB071 was well tolerated, and modest clinical activity was observed in metastatic UM. The genomic findings were consistent with previous reports in primary UM. Together, our data allow envisaging combination therapies of protein kinase C inhibitors with other compounds in metastatic UM.&lt;/p&gt;&lt;/div&gt;
Angiotensin converting enzyme inhibitor induced angio‐oedema: a review of the pathophysiology and risk factors (2009)

Angio-oedema (AE) is a known adverse effect of angiotensin converting enzyme inhibitor (ACE-I) therapy. Over the past several decades, evidence of failure to diagnose this important and potentially fatal reaction is commonly found in the literature. Because this reaction is often seen first in the primary care setting, a review was undertaken to analyse and document the keys to both diagnostic criteria as well as to investigate potential risk factors for ACE-I AE occurrence. A general review of published literature was conducted through Medline, EMBASE, and the Cochrane Database, targeting ACE-I-related AE pathomechanism, diagnosis, epidemiology, risk factors, and clinical decision making and treatment. The incidence and severity of AE appears to be on the rise and there is evidence of considerable delay in diagnosis contributing to significant morbidity and mortality for patients. The mechanism of AE due to ACE-I drugs is not fully understood, but some genomic and metabolomic information has been correlated. Additional epidemiologic data and clinical treatment outcome predictors have been evaluated, creating a basis for future work on the development of clinical prediction tools to aid in risk identification and diagnostic differentiation. Accurate recognition of AE by the primary care provider is essential to limit the rising morbidity associated with ACE-I treatment-related AE. Research findings on the phenotypic indicators relevant to this group of patients as well as basic research into the pathomechanism of AE are available, and should be used in the construction of better risk analysis and clinical diagnostic tools for ACE-I AE.
Left upper division segmentectomy after proton-beam radiation therapy followed by esophagectomy for esophageal cancer (2020)

症例は69歳，男性で，胸部CTにおいて左肺腫瘤を認め，気管支鏡検査にて左肺腺癌と診断された．既往歴として，食道癌に対し放射線化学療法および陽子線照射（計70 Gy）後，食道癌局所再発に対しサルベージ食道切除を施行されていた．陽子線照射野に縦隔以外にも左肺門部血管，気管支が含まれていたこと，低栄養状態（BMI 15.6 kg/m2），糖尿病の併存があったことから，高度な線維化による手術の困難さに加え，気管支断端瘻などのリスクが高いと考えられた．このため，術式として左肺上区域切除を選択し，先に肺動脈本幹をテーピングしてから操作を進め，有茎性広背筋弁にて気管支断端を被覆するなどの工夫を行い，安全に施行することができた．術後経過は良好であり，術後1年無再発であった．
ChemInform Abstract: Simple and Convenient Approach for Synthesis of Tetrahydroquinoline Derivatives and Studies on Aza‐Cope Rearrangement. (2011)

Abstract Tetrahydroquinoline derivatives (II), lilolidines (IV), and julolidines (VI) are obtained by a polyphosphoric acid‐assisted cyclization reaction of corresponding N‐aryl allylanilines.
Identification of an ultimate mutagen of 10-azabenzo[a]pyrene: Microsomal oxidation of 10-azabenzo[a]pyrene to 10-azabenzo[a]pyrene-4,5-oxide. (1979)

10-Azabenzo [α] pyrene (10-ABP), one of most active mutagens, was incubated with microsomal protein. 10-ABP-4, 5-oxide was found by high performance liquid chromatography in the presence of epoxide hydratase inhibitor, 3, 3, 3-trichloropropyrene-1, 2-oxide (TCPO). In the absence of TCPO, formation of 10-ABP-4, 5-oxide was almost negligible and trans-4, 5-dihydroxy-4, 5-dihydro-10-ABP was found as a major metabolite.
Area-Level Socioeconomic Status and Incidence of Abnormal Glucose Metabolism (2012)

Our findings suggest that characteristics of the physical, social, and economic aspects of local areas influence diabetes risk. Future research should focus on identifying the aspects of local environment that are associated with diabetes risk and how they might be modified.
Implementation of fault tolerant control for modular multilevel converter using EtherCAT communication (2015)

Modular Multilevel Converter (MMC) is very promising technology this days. It offers fault tolerant capabilities and ensures high efficiency with low output voltage harmonic content which results in need for smaller filter size. A disadvantage of the system is that the control becomes more cumbersome due to the high number of the employed submodules. A very efficient way to control the MMC is by using a real time communication platform between the sub-modules and a central unit. Thus, the central unit can deal with the overall control and some of the tasks can be distributed to the submodules. This communication platform has to ensure a perfect synchronization between the modules, and it should be also fault tolerant. The analysis of a MMC based on EtherCAT is presented in this paper from implementation and module fault point of view. The experimental tests show that the MMC operates after communication or module hardware fault occurred.