gebhart/patrepeval huggingface dataset:
An IFN-γ-Independent Proinflammatory Role of IL-18 in Murine Streptococcal Cell Wall Arthritis (2000)

IL-18 is a member of the IL-1 family of proteins that exerts proinflammatory effects. It was formally known as IFN-gamma-inducing factor and is a pivotal cytokine for the development of Th1 responses. Apart from Th1 immune-stimulatory activity, IL-18 induces the production of proinflammatory cytokines such as TNF-alpha and IL-1 in vitro. The goal was to investigate the role of endogenous IL-18 in murine streptococcal cell wall (SCW)-induced arthritis. Furthermore, we investigated whether IL-18 neutralization had an impact on local TNF and IL-1 production. C57BL/6, BALB/c, and IFN-gamma-deficient mice were injected with 2 mg of rabbit anti-murine IL-18 Abs shortly before induction of arthritis by intra-articular injection of 25 microg of SCW fragments into the right knee joint. Suppression of joint swelling was noted on days 1 and 2 of SCW arthritis after blockade of endogenous IL-18. Analysis of local cytokine concentrations showed that IL-18, TNF-alpha, and IL-1ss levels were decreased. Severe inhibition of chondrocyte proteoglycan synthesis was seen in the vehicle-treated control animals, whereas a reversal of the inhibition of chondrocyte proteoglycan synthesis was found in the anti-IL-18-exposed animals. Blockade of endogenous IL-18 in IFN-gamma-deficient mice showed results similar to those found in wild-type animals, identifying a role for IL-18 that is IFN-gamma independent. The present study indicates that IL-18 is a proinflammatory cytokine during the onset of murine SCW arthritis, and this inflammatory role of IL-18 is IFN-gamma independent.
Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs (2021)

We recently reported that RNAi-mediated off-target effects are important drivers of the hepatotoxicity observed for a subset of GalNAc-siRNA conjugates in rodents, and that these findings could be mitigated by seed-pairing destabilization using a single GNA nucleotide placed within the seed region of the guide strand. Here, we report further investigation of the unique and poorly understood GNA/RNA cross-pairing behavior to better inform GNA-containing siRNA design. A reexamination of published GNA homoduplex crystal structures, along with a novel structure containing a single (S)-GNA-A residue in duplex RNA, indicated that GNA nucleotides universally adopt a rotated nucleobase orientation within all duplex contexts. Such an orientation strongly affects GNA-C and GNA-G but not GNA-A or GNA-T pairing in GNA/RNA heteroduplexes. Transposition of the hydrogen-bond donor/acceptor pairs using the novel (S)-GNA-isocytidine and -isoguanosine nucleotides could rescue productive base-pairing with the complementary G or C ribonucleotides, respectively. GalNAc-siRNAs containing these GNA isonucleotides showed an improved in vitro activity, a similar improvement in off-target profile, and maintained in vivo activity and guide strand liver levels more consistent with the parent siRNAs than those modified with isomeric GNA-C or -G, thereby expanding our toolbox for the design of siRNAs with minimized off-target activity.
ChemInform Abstract: Factors Governing the Catalytic Reactivity of Metallic Nanoparticles (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Table S2 from An Integrated Approach Identifies Mediators of Local Recurrence in Head and Neck Squamous Carcinoma (2023)

&lt;p&gt;Supplementary Table S2: Pathway enrichment analyses of miRs putative targets.&lt;/p&gt;
Alternative subband signal structures for complex modulated filter banks with perfect reconstruction (2004)

In this paper, two critically sampled perfect reconstruction complex modulated filter banks, used with complex-valued input signals, are compared. The modified discrete Fourier transform filter bank (MDFT-FB) and the recently introduced exponentially modulated filter bank (EMFB) have different approach for critical sampling and they use different channel stacking agreement. It is shown that with certain special modifications, the EMFB system can provide exactly the same subband signal values for the subband processing as the MDFT-FB system. An intuitive and simple spectral interpretation of these modifications and alternative spectral structure of the subband signals are also given.
Blood Pressure Response to Dietary Calcium Intervention in Humans (1990)

Epidemîologìcal and experimental studies have suggested that dietary calcium deficiency may lead to the development of hypertension. This article reviews findings in human trials on calcium intervention with special reference to the responses of blood pressure and biochemical variables. Calcium supplementation consistently resulted in decreased blood pressure in a subset of hypertensive and normotensive subjects, but led to increased blood pressure in some hypertensive patients. The variable blood pressure responses to calcium supplementation could not be predicted on the basis of routine biochemical parameters and appeared to be due to differences in the backgrounds of the subjects and/or the design and size of the trials. It is concluded that further studies are required on the hypotensive effect of calcium supplementation. Am J Hypertens 1990;3:147S-151S
Corrections to “Modeling and Analysis of a Novel Variable Speed Cage Induction Generator” [Feb 12 1020-1028] (2012)

Reference [1] given here, which dealt with a topology similar to the one in the above-named paper was inadvertently omitted.
Isotope Effects on Metastable Transitions in Mass Spectra (1964)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Marvin L. Vestal; Isotope Effects on Metastable Transitions in Mass Spectra. J. Chem. Phys. 15 December 1964; 41 (12): 3997–3998. https://doi.org/10.1063/1.1725849 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioThe Journal of Chemical Physics Search Advanced Search |Citation Search
Reproducibility of coronary artery calcium quantification on dual-source CT and dual-source photon-counting CT: a dynamic phantom study (2022)

To systematically compare coronary artery calcium (CAC) quantification between conventional computed tomography (CT) and photon-counting CT (PCCT) at different virtual monoenergetic (monoE) levels for different heart rates. A dynamic (heart rates of 0, < 60, 60-75, and > 75 bpm) anthropomorphic phantom with three calcification densities was scanned using routine clinical CAC protocols with CT and PCCT. In addition to the standard clinical protocol of 70 keV, PCCT images were reconstructed at monoE levels of 72, 74, and 76 keV. CAC was quantified using Agatston, volume, and mass scores. Agatston scores 95% confidence intervals (CI) were calculated and compared between PCCT and CT. Volume and mass scores were compared with physical quantities. For all CAC densities, routine clinical protocol Agatston scores of static CAC were higher for PCCT compared to CT. At < 60 bpm, Agatston scores at 74 and 76 keV reconstructions were reproducible (overlapping CI) for PCCT and CT. Increased heart rates yielded different Agatston scores for PCCT in comparison with CT, for all monoE levels. Low density CAC volume scores showed the largest deviation from physical volume, with mean deviations of 59% and 77% for CT and PCCT, respectively. Overall, mass scores underestimated physical mass by 10%, 38%, and 59% for low, medium, and high density CAC, respectively. PCCT allows for reproducible Agatston scores for dynamic CAC (< 60 bpm) when reconstructed at monoE levels of 74 or 76 keV, regardless of CAC density. Deviations from physical volume and mass were, in general, large for both CT and PCCT.
S2473 Obscure Chemical Causing Fulminant Hepatic Failure (2020)

INTRODUCTION: Fulminant hepatic failure (FHF) is characterized by severe acute liver failure with impaired synthetic function and encephalopathy in patients without prior liver diease. FHF can result in coagulopathy, increased risk of infection, metabolic derangements including acute renal failure, electrolyte abdnormalities, and pancreatitis. Toxins and viral hepatitis are the most common causes of FHF. Here we present a case of FHF due to poisoning by an unknown chemical. CASE DESCRIPTION/METHODS: A 45-year-old female with no prior liver disease presented to the ED for sudden onset of burning sensation along her chest, abdomen, and extremities, associated with shivering and watery diarrhea for 1 day. The patient suspects someone spraying a white chemical into her house prior to her developing these symptoms. Labs on admission revealed ALT 945IU/L, AST 2405IU/L with normal ALP, CBC, and renal function. The next day she became encephalopathic and liver enzymes worsened to AST 5040IU/L and ALT 13080IU/L. The patient’s GTT was 1499IU/L, ammonia 258µ/dL, INR 1.7, total bilirubin 5.8mg/dl with a direct bilirubin of 4.0mg/dl. A complete infectious, antibody and common drug toxicity workup were negative. Both Ultrasound Abdomen with Doppler and CT Abdomen was normal. The patient was treated with lactulose and a 21-hour N-Acetylcysteine transfusion regimen. Though there were some improvements clinically, her liver enzymes were still very high mandating transfer to a tertiary facility for possible liver transplantation. However, the patient continued to improve in the next couple of weeks with only supportive management and was discharged home with normal liver enzymes after almost a month of hospitalization. Official authorities continue to investigate the cause of poisoning although toxicology experts suggest a possibility of trichloroethylene, white phosphorous, or nitroaromatic exposure. DISCUSSION: Common toxins associated with FHF include ecstasy, acetaminophen, anti-tuberculous drugs, NSAIDs, or Amanita mushroom poisoning. N-acetylcysteine can significantly improve the prognosis of acetaminophen intoxication however it has also been used in other conditions as a last resort like in our patient which showed a possible benefit. In FHF, the probability of spontaneous hepatic recovery can be predicted by the severity of encephalopathy, patient's age, and the cause of FHF. This determines the urgency for liver transplantation which is the only proven therapy to improve survival in these patients.
Frank-van der Merwe Growth in Bilayer Graphene (2020)

&lt;p&gt;Bilayer graphene has attracted interest for its unique properties, including interesting electrical behavior when one layer is slightly rotated relative to the other. However, the quality of large-area bilayer graphene is often limited by the layer-plus-island growth mode in which islands of thicker graphene present as unavoidable impurities. Here, we report the observation of the layer-by-layer, Frank-van der Merwe (FM) growth mode in bilayer graphene where multilayer impurities are suppressed. Instead of the conventional surface adhesive energy, it is found that interface adhesive energy is possible to be tuned with an oxidative pretreatment. The FM-grown bilayer graphene is of AB-stacking or with small-twisting-angle (θ = 0-5°), which is more mechanically robust compared to monolayer graphene, facilitating a free-standing wet transfer technology.&lt;/p&gt;
A679. A MULTICENTER STUDY OF IN VIVO KINEMATICS OF A ROTATING PLATFORM POSTERIOR STABILIZING TKA DESIGNED TO REDUCE CONTACT STRESS (2011)

Subjects having a posterior cruciate ligament sacrificing (PCLS) mobile bearing TKA seem to experience less translation during gait, but often achieve less weight-bearing flexion. More recently, posterior stabilisation has been added to PCLS mobile bearing TKA, hoping to increase flexion. Therefore, the objective of this multi-center study was to determine the in vivo kinematics for subjects implanted with a mobile bearing PS TKA that attempts to maintain high contact area. Subjects with 10 TKA from 2 surgeons were asked to perform maximum weight-bearing flexion (deep knee bend (DKB)) and gait while under fluoroscopic surveillance. During weight bearing flexion, the 3-D kinematics of the TKA were determined by analyzing fluoroscopic images in the sagittal plane at 30 degree increments. Fluoroscopic images taken in the frontal plane from four increments during the stance phase of gait were analyzed. The average weight-bearing flexion was 116 degrees and the average medial and lateral anteriorposterior (AP) translation was posterior with −1.9 mm and −5.4 mm, respectively, from full extension to maximum weight-bearing flexion. The average femorotibial axial rotation from full extension to maximum weight-bearing flexion was 3.9 degrees. During the stance phase of treadmill gait, patients experienced 0.8 mm (0.1 mm to 2.3 mm, SD=0.8 mm) of “pure” mediolateral translation of the femur relative to the tibia. The femorotibial axial rotation was 4.6 degrees from heel-strike to toe-off (Table 3). The posterior femoral rollback and axial rotation patterns were similar to the normal knee, albeit experiencing less overall motion. More noticeably, subjects in this study experienced a significantly greater weight-bearing flexion than previous subjects analyzed with a mobile bearing PCLS TKA and more reproducible “fan-like” patterns, where the lateral condyle rolled greater posteriorly than the medial condyle.
Intersectionality Goes Analytical: Taming Combinatorial Explosion Through Type Abstraction (2022)

HCI researchers' and practitioners' awareness of intersectionality has been expanding, producing knowledge, recommendations, and prototypes for supporting intersectional populations. However, doing intersectional HCI work is uniquely expensive: it leads to a combinatorial explosion of empirical work (expense 1), and little of the work on one intersectional population can be leveraged to serve another (expense 2). In this paper, we explain how representations employed by certain analytical design methods correspond to type abstractions, and use that correspondence to identify a (de)compositional model in which a population's diverse identity properties can be joined and split. We formally prove the model's correctness, and show how it enables HCI designers to harness existing analytical HCI methods for use on new intersectional populations of interest. We illustrate through four design use-cases, how the model can reduce the amount of expense 1 and enable designers to leverage prior work to new intersectional populations, addressing expense 2.
EGFR-T790M Is a Rare Lung Cancer Susceptibility Allele with Enhanced Kinase Activity (2007)

The use of tyrosine kinase inhibitors (TKI) has yielded great success in treatment of lung adenocarcinomas. However, patients who develop resistance to TKI treatment often acquire a somatic resistance mutation (T790M) located in the catalytic cleft of the epidermal growth factor receptor (EGFR) enzyme. Recently, a report describing EGFR-T790M as a germ-line mutation suggested that this mutation may be associated with inherited susceptibility to lung cancer. Contrary to previous reports, our analysis indicates that the T790M mutation confers increased Y992 and Y1068 phosphorylation levels. In a human bronchial epithelial cell line, overexpression of EGFR-T790M displayed a growth advantage over wild-type (WT) EGFR. We also screened 237 lung cancer family probands, in addition to 45 bronchoalveolar tumors, and found that none of them contained the EGFR-T790M mutation. Our observations show that EGFR-T790M provides a proliferative advantage with respect to WT EGFR and suggest that the enhanced kinase activity of this mutant is the basis for rare cases of inherited susceptibility to lung cancer.
Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways (2015)

Metabolic switches in various immune cell subsets enforce phenotype and function. In the present study, we demonstrate that the active form of vitamin D, 1,25-dihydroxyvitamin D<sub>3</sub> (1,25(OH)<sub>2</sub>D<sub>3</sub>), induces human monocyte-derived tolerogenic dendritic cells (DC) by metabolic reprogramming. Microarray analysis demonstrated that 1,25(OH)<sub>2</sub>D<sub>3</sub> upregulated several genes directly related to glucose metabolism, tricarboxylic acid cycle (TCA), and oxidative phosphorylation (OXPHOS). Although OXPHOS was promoted by 1,25(OH)<sub>2</sub>D<sub>3</sub>, hypoxia did not change the tolerogenic function of 1,25(OH)<sub>2</sub>D<sub>3</sub>-treated DCs. Instead, glucose availability and glycolysis, controlled by the PI3K/Akt/mTOR pathway, dictate the induction and maintenance of the 1,25(OH)<sub>2</sub>D<sub>3</sub>-conditioned tolerogenic DC phenotype and function. This metabolic reprogramming is unique for 1,25(OH)<sub>2</sub>D<sub>3</sub>, because the tolerogenic DC phenotype induced by other immune modulators did not depend on similar metabolic changes. We put forward that these metabolic insights in tolerogenic DC biology can be used to advance DC-based immunotherapies, influencing DC longevity and their resistance to environmental metabolic stress.
2.1 kW single mode continuous wave monolithic fiber laser (2015)

A robust, alignment-free monolithic 2.1 kW single-mode continuous wave fiber laser, operating at 1083 nm is demonstrated. The laser is pumped with commercial fiber pigtailed multimode diodes through all-fiber pump-signal power combiners in a MOPA architecture. The oscillator was formed with high reflector and output coupler fiber Bragg gratings written in 11/200 &mu;m (mode field/cladding diameter) single-mode fiber. The gain medium was a 19m OFS commercial 11/200 &mu;m double clad Yb-doped fiber (DCY). Pump light was coupled to the oscillator using two 11/200 &mu;m pump-signal power combiners (PSC). A total of 20 commercially available 58W pump diodes at 915 nm were used to generate 800W of signal, as measured before the amplifier. The Raman power after the oscillator was more than 60 dB below the signal power. The amplifier was built using 13 m of 14/200 µm DCY and two (18+1)x1 PSC combiners with more than 95% pump and signal light transmission. A total of 2 kW of power was used to bi-directionally pump the amplifier. The output was measured after 3 m 14/200 &mu;m fiber, and 10 m 100/360 &mu;m delivery cable. Total signal output power was 2.1 kW, corresponding to an amplifier slope efficiency of 77%. The Raman power is more than 30 dB below the signal power. At maximum power, no modal instabilities, thermal effects, nor power rollover were observed. With higher power pumps, it is predicted that a power level of 2.6 kW can be achieved with the Raman level below 20 dB.
Up-righting Dual-Chamber Cardiac Pacing. The Story of Managed Ventricular Pacing (2020)

A significant milestone in cardiac pacing occurred approximately two decades ago when the primary operating mode was reimagined to more closely mimic normal top-down cardiac activation. Managed Ventricular Pacing (MVP™) was an unprecedented dual-chamber mode as it preferentially paced the right atrium in the AAI/R mode and simultaneously protected against transient heart block, but only in the instance of a dropped ventricular beats. At the time, dual chamber DDD/R with atrial based timing and programmable atrioventricular (AV) delay was the state of the art. MVP “unlocked” conventional dual-chamber pacing by not consistently requiring a 1:1 atrioventricular relationship as defined by an AV delay during its primary operating mode (i.e. AAI/R+). Described herein is the remarkable story of MVP, conceived before the pivotal and highly supportive Dual-Chamber and VVI Implantable Defibrillator (DAVID) Trial was introduced and rooted in lessons learned from “first-in man” permanent His bundle pacing.
Remaining useful life prediction based on the mixed effects model with mixture prior distribution (2016)

Modern engineering systems are gradually becoming more reliable and premature failure has become quite rare. As a result, degradation signal data used for prognosis are often imbalanced as most units are reliable and only few tend to fail at early stages of their life cycle. Such imbalanced data may hinder accurate Remaining Useful Life (RUL) prediction especially in terms of detecting premature failures as early as possible. This aspect is detrimental for developing cost-effective condition-based maintenance strategies. In this article, we propose a degradation signal–based RUL prediction method to address the imbalance issue in the data. The proposed method introduces a mixture prior distribution to capture the characteristics of different groups within the same population and provides an efficient and effective online prediction method for the in-service unit under monitoring. The advantageous features of the proposed method are demonstrated through a numerical study as well as a case study with real-world data in the application to the RUL prediction of automotive lead–acid batteries.
New nonlinear optical microscope and its application to the observation of ferroelectric domain structure (1995)

Abstract We have constructed a new nonlinear optical device called the SHG microscope. In the microscope, the fundamental wave with λ = 1.06 μm from a Nd:YAG laser enters a specimen and the second harmonic waves emitted from the specimen are collected by the IR objective lens and the two-dimen-sional image is detected by the CCD camera. By using the SHG microscope, we observed several kinds of specimens with inhomogeneous distribution of the nonlinear optical constant. In particular, we succeeded in observing 90° domains in BaTiO3 and a periodically inverted antiparallel ferroelectric domain in LiTaO3 in a nondestructive way. The general method for observing antiparallel ferroelectric domain structure is discussed.
2.5-Inch Patterned Media Prepared by an Artificially Assisted Self-Assembling Method. (2003)

A new method of fabricating patterned media was developed. Circumferential magnetic patterned media were prepared on 2.5-inch-diameter glass plates. A Ni master disk contraining spiral patterns with 60-250-nm-wide lands and a 400-nm-wide groove was pressed against a resist film on a CoPt or CoCrPt film to transfer the spiral patterns. A diblock copolymer solution was cast into the obtained grooves, and then annealed to prepare self-assembling dot structures aligned along the grooves. According to the dot patterns, lower magnetic films were patterned by ion milling to yield patterned media with a 40-nm diameter. The coercive forces and squareness ratios of the patterned media were greater than those of continuous media. Single magnetic domains with an almost perpendicular orientation were confirmed in each magnetic dot.
Fast and compact internal scanning CMOS-based hyperspectral camera: the Snapscan (2017)

Imec has developed a process for the monolithic integration of optical filters on top of CMOS image sensors, leading to compact, cost-efficient and faster hyperspectral cameras. Linescan cameras are typically used in remote sensing or for conveyor belt applications. Translation of the target is not always possible for large objects or in many medical applications. Therefore, we introduce a novel camera, the Snapscan (patent pending), exploiting internal movement of a linescan sensor enabling fast and convenient acquisition of high-resolution hyperspectral cubes (up to 2048x3652x150 in spectral range 475–925 nm). The Snapscan combines the spectral and spatial resolutions of a linescan system with the convenience of a snapshot camera.
Free Radical Mediated Vinyl Amination: Access‐to N,N‐Dialkyl Enamines and Their β‐Stannyl and β‐Thio Derivatives. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.