gebhart/patrepeval huggingface dataset:
Control method for improving the response of single‐phase continuous conduction mode boost power factor correction converter (2016)

Continuous conduction mode power factor correction AC–DC converters are widely employed as the front stage in power supplies with medium or high output power. The second‐order reactive input power in single‐phase systems causes second‐order ripple in the DC‐link voltage. The speed of voltage regulation is thus limited by the second‐order frequency in seeking to achieve low distorted input current. This study presents a fast second‐order voltage estimation method, wherein an integrator is used for the estimation of second‐order voltage ripple to obtain rapid voltage feedback without ripple and thereby cope with the limitations imposed by the second‐order frequency. This approach greatly expands the bandwidth of the voltage control loop beyond the second‐order frequency while reducing the total harmonic distortion associated with the input current. This also makes it possible to reduce the DC capacitance to reduce costs. The authors opted for full digital control using a TI F28335 DSP IC, in conjunction with feedback plus feedforward control to facilitate the design of the current loop. A feedback current corrector is used to reduce distortion associated with the input current over a wide load range. The effectiveness of the proposed control method was confirmed with some simulation and experimental results.
An auxiliary peptide required for the function of two activation domains in upstream stimulatory factor 2 (USF2) transcription factor (1997)

Ubiquitous upstream stimulatory factors (USF1, USF2a and USF2b) are members of the basic-helix-loop-helix-leucine-zipper family of transcription factors that have been shown to be involved in the transcriptional response of the L-type pyruvate kinase (L-PK) gene to glucose. To understand the mechanisms of action of the USF2 isoforms, we initiated a series of co-transfection assays with deletion mutants and Ga14-USF2 fusions. The transactivating efficiency of the different native and mutant factors was determined at similar DNA binding activity. We found that: (i) exons 3- and 5-encoded regions are activation domains, (ii) a modulator domain encoded by exon 4 could be necessary to their additive action, (iii) a hexapeptide encoded by the first 5' codons of exon 6 is indispensable for transmitting activation due to both exon 3- and exon 5-encoded domains to the transcriptional machinery. Therefore, USF2 presents a modular structure and mediates transcriptional activation thanks to two non-autonomous activation domains dependent on an auxiliary peptide for expressing their activating potential.
One-dimensional small-angle X-ray scattering tomography of dip-coated polyamide 6 monofilaments (2010)

A synchrotron study is presented in which the concept of one-dimensional tomographic reconstruction of small-angle X-ray scattering patterns is applied to investigate polyamide 6 monofilaments, dip-coated with alumina particles. The filaments are scanned with a focused synchrotron beam and the resulting scattering patterns are recorded with a PILATUS 2M detector. The reconstructed sequence of SAXS images reflects the local nanostructure variation along the filament radius. In particular, the influence of coating process parameters on the polyamide 6 is investigated.
Table S2 from EMP2 Is a Novel Regulator of Stemness in Breast Cancer Cells (2023)

&lt;p&gt;Characteristics of 23 mammary and breast cancer cell lines.&lt;/p&gt;
Evaluation of LY573144 (lasmiditan) in a preclinical model of medication overuse headache (2020)

In a pre-clinical rat model of MOH, oral lasmiditan, like sumatriptan, induced acute transient cutaneous allodynia in the periorbital and hindpaw regions that after resolution could be re-evoked by putative migraine triggers. These results suggest that lasmiditan has the capacity to induce MOH through persistent latent peripheral and central sensitization mechanisms.
Performance Verification of Vertical Seismic Isolation Equipment Using Negative Rigidity Mechanism (2022)

In recent years, various seismic isolation devices have been developed to prevent earthquake damage to valuable art works. The purpose of this study is to develop a vertical seismic isolation system that both reduces the natural frequency and solves the problems of vertical seismic isolation systems in previous studies. In this study, we developed a vertical seismic isolator that supports the load with inclined springs without using vertical springs. A motor is mounted on the ball screw that constitutes the central axis of each crank mechanism. The vertical stiffness of this seismic isolator can be changed using the motor. In this study, the seismic isolation performance was improved by using the negative stiffness property to set the natural frequency lower. The vertical seismic isolation system was modeled using SimulationX. The characteristics of the vertical seismic isolation system were verified and its performance was evaluated by various experiments and simulations. The MBS model of the newly developed device was used to accurately simulate the loading characteristics of the vertical isolator such as negative stiffness characteristics. The performance of this vertical isolator was verified by vibration experiments and simulations assuming typical seismic waves in Japan. The average response factor of acceleration in the experiment was 17.8%, and the average response factor in the simulation was 15.9%, which exceeded the performance of the device in the previous study. Finally, in the resonance avoidance test, the acceleration of the top plate of the vertical base isolation system was reduced by 57% by using the vertical natural frequency adjustment mechanism to avoid resonance.
A Large Thermal Hysteresis Loop Produced by a Charge-Transfer Phase Transition in a Rubidium Manganese Hexacyanoferrate (2004)

In a rubidium manganese hexacyanoferrate, RbMn[Fe(CN)(6)], the magnetic susceptibility (chi(M)) decreased at 225 K (=T(1/2)decreasing) and abruptly increased at 300 K (=T(1/2)increasing) in the cooling and warming processes, respectively. X-ray photoelectron spectroscopy and infrared spectroscopy indicated that the high-temperature (HT) and low-temperature (LT) phases were composed of Mn(II)-NC-Fe(III) and Mn(III)-NC-Fe(II), respectively. A structural change from cubic (F43m, a = 10.533 A) to tetragonal (I4m2, a = b = 7.090 A, c = 10.520 A) accompanied the phase transition, and, on the basis of these results, the HT and LT phases were assigned to Mn(II)(t(2g)(3)e(g)(2), (6)A(1g); S = (5)/(2))-NC-Fe(III) (t(2g)(5), (2)T(2g); S = (1)/(2)) and Mn(III)(e(g)(2)b(2g)(1)a(1g)(1), (5)B(1g); S = 2)-NC-Fe(II) (b(2g)(2)e(g)(4), (1)A(1g); S = 0), respectively. This phenomenon is caused by a metal-to-metal charge transfer from Mn(II) to Fe(III) and a Jahn-Teller distortion of the produced Mn(III) ion. The reaction mechanism is discussed, considering the entropy difference between the HT and LT phases.
THE SRI NIST 2008 speaker recognition evaluation system (2009)

The SRI speaker recognition system for the 2008 NIST speaker recognition evaluation (SRE) incorporates a variety of models and features, both cepstral and stylistic. We highlight the improvements made to specific subsystems and analyze the performance of various subsystem combinations in different data conditions. We show the importance of language and nativeness conditioning, as well as the role of ASR for speaker verification.
Subsystem Identification Through Dimensionality Reduction of Large-Scale Gene Expression Data (2003)

The availability of parallel, high-throughput biological experiments that simultaneously monitor thousands of cellular observables provides an opportunity for investigating cellular behavior in a highly quantitative manner at multiple levels of resolution. One challenge to more fully exploit new experimental advances is the need to develop algorithms to provide an analysis at each of the relevant levels of detail. Here, the data analysis method non-negative matrix factorization (NMF) has been applied to the analysis of gene array experiments. Whereas current algorithms identify relationships on the basis of large-scale similarity between expression patterns, NMF is a recently developed machine learning technique capable of recognizing similarity between subportions of the data corresponding to localized features in expression space. A large data set consisting of 300 genome-wide expression measurements of yeast was used as sample data to illustrate the performance of the new approach. Local features detected are shown to map well to functional cellular subsystems. Functional relationships predicted by the new analysis are compared with those predicted using standard approaches; validation using bioinformatic databases suggests predictions using the new approach may be up to twice as accurate as some conventional approaches.
Arthroscopic Treatment of the Arthritic Elbow (2005)

Elbow arthroscopy is now being used with greater frequency to treat arthritis and contractures. The procedure is technically demanding and the potential for injury to neurovascular structures remains a concern. Potential advantages of arthroscopic treatment include improved articular visualization and decreased postoperative pain. Patients may also benefit from decreased morbidity and a faster postoperative recovery. Elbow arthroscopy can be performed for removal of loose bodies, resection of symptomatic plica, release of the capsule in patients with contracture, removal of osteophytes, treatment of synovectomy in inflammatory arthritis, treatment of osteochondritis dissecans, débridement of lateral epicondylitis, and treatment of elbow fractures.
<title>Visually based color space tetrahedrizations for printing with custom inks</title> (2000)

Printing with custom inks is useful for extending the gamut of printed images, for creating artistically appealing design or for providing protection against counterfeiting. The basic colors we consider, consist of the custom inks, their superpositions and the white paper. Color separation for custom inks requires to determine the relative amounts of the basic colors allowing to render each desired input color. To achieve this goal, one may tetrahedrize the set of basic colors on a given 3D color space. However, even for a few basic colors, there are many different tetrahedrizations.
Productive sugar isomerization with highly active Sn in dealuminated β zeolites (2013)

A water-tolerant Lewis acid catalyst was synthesized by grafting SnIV in isopropanol under reflux onto dealuminated zeolites with the BEA (β) topology. This synthesis method allows the production of highly active Snβ-type catalysts without the need for long hydrothermal syntheses or hydrogen fluoride, while using cheap Sn-precursors, industrially available β zeolites and standard catalyst synthesis unit operations. Extensive characterization of the best catalyst shows highly dispersed Sn in the zeolite matrix (XRD, 29Si MAS NMR and 1H MAS NMR) without the formation of SnO2 (XRD and UV-Vis). The catalyst was tested for the model isomerization of sugars such as glucose to fructose. The catalytic activity proved to be purely heterogeneous and the catalyst was recycled and reused without significant loss in activity. Isomerization productivities above 4 kg product per kg of catalyst per hour are reported with appreciably low Sn loadings, corresponding to exceptionally high turnover frequencies, viz. 500 cycles per Sn per hour at 110 °C, which surpass the activity per Sn of the original hydrothermally synthesized Snβ.
Prolonged Viral RNA Detection in Blood and Lymphoid Tissues from Coxsackievirus B4 E2 Orally‐Inoculated Swiss Mice (2006)

The spreading of viral RNA within Swiss Albino mice orally inoculated with coxsackievirus B4 E2 strain (CVB4 E2) was studied by using RT-PCR and semi-nested-RT-PCR methods. Viral RNA was detected in various organs: pancreas, heart, small intestine, spleen, thymus, and blood at various postinfectious (p.i.) times ranging from 8 hr to 150 days. Our results show that (i) outbred mice can be infected with CVB4 E2 following an oral inoculation, which results in systemic spreading of viral RNA, (ii) CVB4 E2 infection can be associated with a prolonged detection of viral RNA in spleen, thymus and blood, up to 70 days p.i. and further in other organ tissues.
Modeling and analysis of coplanar waveguide (CPW) based multilayer on-chip inductors (2011)

CPW based multilayer inductors which can provide higher frequency band and Q factor value are studied and characterized so that a new microwave Equivalent circuit model may be found. In order to study the correlation between the inductance and the length, width and thickness of the conductor, EM structures of multilayer inductors are designed and compared of electrical models. Data analysis and graphic comparison of inductance, S-parameter will be collected and shown.
In-fiber production of polymeric particles for biosensing and encapsulation (2013)

Polymeric micro- and nanoparticles are becoming a mainstay in biomedicine, medical diagnostics, and therapeutics, where they are used in implementing sensing mechanisms, as imaging contrast agents, and in drug delivery. Current approaches to the fabrication of such particles are typically finely tuned to specific monomer or polymer species, size ranges, and structures. We present a general scalable methodology for fabricating uniformly sized spherical polymeric particles from a wide range of polymers produced with complex internal architectures and continuously tunable diameters extending from the millimeter scale down to 50 nm. Controllable access to such a wide range of sizes enables broad applications in cancer treatment, immunology, and vaccines. Our approach harnesses thermally induced, predictable fluid instabilities in composite core/cladding polymer fibers drawn from a macroscopic scaled-up model called a "preform." Through a stack-and-draw process, we produce fibers containing a multiplicity of identical cylindrical cores made of the polymers of choice embedded in a polymer cladding. The instability leads to the breakup of the initially intact cores, independent of the polymer chemistry, into necklaces of spherical particles held in isolation within the cladding matrix along the entire fiber length. We demonstrate here surface functionalization of the extracted particles for biodetection through specific protein-protein interactions, volumetric encapsulation of a biomaterial in spherical polymeric shells, and the combination of both surface and volumetric functionalities in the same particle. These particles used in distinct modalities may be produced from the desired biocompatible polymer by changing only the geometry of the macroscopic preform from which the fiber is drawn.
Evaluation of circulating current suppression methods for parallel interleaved inverters (2016)

Two-level Voltage Source Converters (VSCs) are often connected in parallel to achieve desired current rating in multi-megawatt Wind Energy Conversion System (WECS). A multi-level converter can be realized by interleaving the carrier signals of the parallel VSCs. As a result, the harmonic performance of the WECS can be significantly improved. However, the interleaving of the carrier signals may lead to the flow of circulating current between parallel VSCs and it is highly desirable to avoid/suppress this unwanted circulating current. A comparative evaluation of the different methods to avoid/suppress the circulating current between the parallel interleaved VSCs is presented in this paper. The losses and the volume of the inductive components and the semiconductor losses are evaluated for the WECS with different circulating current suppression methods. Multi-objective optimizations of the inductive components have been also carried out. The design solutions, that are obtained using the optimization, have been compared on the basis of the volume of the inductive components and yearly energy loss for a given mission profile.
Prostanoid Receptor Antagonist Effects on Intraocular Pressure, Supported by Ocular Biodisposition Experiments (2016)

These antagonist studies provided no evidence for individual endogenous prostanoids exerting a meaningful role in regulating IOP. They do reaffirm the critical importance of studying ocular bioavailability for confirming negative data. Large differences among the antagonists in anterior segment and even ocular surface tissue biodisposition were observed in rabbits. It appears from these monkey studies, supported by rabbit ocular bioavailability data, that an absence of drug effect in the eye cannot be adequately substantiated without determination of ocular pharmacokinetics.
"Lineage Addiction" in Human Cancer: Lessons from Integrated Genomics (2005)

Genome-era advances in the field of oncology endorse the notion that many tumors may prove vulnerable to targeted therapeutic avenues once their salient molecular alterations are elucidated. Accomplishing this requires both detailed genomic characterization and the ability to identify in situ the critical dependencies operant within individual tumors. To this end, DNA microarray platforms such as high-density single-nucleotide polymorphism (SNP) arrays enable large-scale cancer genome characterization, including copy number and loss-of-heterozygosity analyses at high resolution. Clustering analyses of SNP array data from a large collection of tumor samples and cell lines suggest that certain copy number alterations correlate strongly with the tissue of origin. Such lineage-restricted alterations may harbor novel cancer genes directing genesis or progression of tumors from distinct tissue types. We have explored this notion through combined analysis of genome-scale data sets from the NCI60 cancer cell line collection. Here, several melanoma cell lines clustered on the basis of increased dosage at a region of chromosome 3p containing the master melanocyte regulator MITF. Combined analysis of gene expression data and additional functional studies established MITF as an amplified oncogene in melanoma. MITF may therefore represent a nodal point within a critical lineage survival pathway operant in a subset of melanomas. These findings suggest that, like oncogene addiction, "lineage addiction" may represent a fundamental tumor survival mechanism with important therapeutic implications.
RTHP-27. PHASE I/II STUDY OF DDFPe AS A RADIOSENSITIZER IN GLIOBLASTOMA (2016)

Describe the interim results of a Phase Ib/II clinical trial of dodecafluoropentane emulsion (DDFPe) as a radiosensitizer in chemoradiation of glioblastoma multiforme (GBM). With informed consent and IRB approval 10 adult GBM patients have been enrolled in the trial. Patients are administered IV DDFPe (2% w/vol at doses of 0.05 mL/kg, 0.1 mL/ kg or 0.17 mL/kg) 30-60 minutes prior to radiation therapy with oxygen or carbogen breathing. To confirm tumor re-oxygenation, patients underwent TOLD MRI before and after DDFPe administration. Patients were treated with 30 fractions of radiotherapy (2 Gy each). Archived tumor specimens are studied with GliomaSTRAT® assay for methylated genes predictive of response. Patients were also studied with serial MR scans as per standard of care and for survival. One patient received the 0.05 mL/kg dose, 8 patients received the 0.1 mL/kg dose and 1 patient received the 0.17 mL/kg dose. There were no acute adverse events related to administration of DDFPe. One patient at each of dose levels 0.1 mL/kg and 0.17 mL/kg developed symptomatic radiation necrosis (confirmed by histopathology), which was judged to be related to DDFPe. Enrollment has continued at the 0.1 mL/kg dose without additional significant DDFPe-related toxicity. TOLD MRI showed significant decrease in T1 of tumor tissue consistent with tumor re-oxygenation. First patient was predicted temozolomide (TMZ) non-responder (TMZ-) and survived 21 months. Second patient (TMZ+) is alive 20 months. Third patient (TMZ-) who had excessive radiation necrosis is alive at 15 months and improving symptomatically. All other patients are alive but less than 1-year follow-up at this time. DDFPe is a promising oxygen therapeutic for reversing tumor hypoxia and merits Phase II study.
79‐1: Invited Paper: New Liquid Crystals for Light Guiding Application: From Automotive Headlights to Adaptive Indoor Lighting (2017)

Recently, there has been a renewed interest in using liquid crystal devices for lighting applications. The applications include car headlamps as well as indoor architectural lighting. In this paper we will present the status of liquid crystal mixtures that are suitable for these applications. or automotive applications, the properties of the liquid crystal mixtures are expected to include robustness towards extreme environmental conditions as well as robustness towards extreme light load. For architectural application, the liquid crystals mixtures are expected to have the highest possible birefringence whilst still having good light stability.
Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes. (1990)

The type I human T-cell leukemia virus (HTLV-I) encodes a 40-kD nuclear trans-regulatory protein termed Tax that transcriptionally activates the HTLV-I long terminal repeat (LTR), as well as select [corrected] cellular and heterologous viral promoters. Tax does not bind DNA specifically but, rather, acts in a more indirect manner. Tax activation of the HTLV-I LTR is mediated through constitutively expressed cellular factors that bind to cAMP response elements (CREs) present within the 21-bp enhancers of the LTR. In contrast, Tax transactivation of the interleukin-2 receptor-alpha gene (IL-2R alpha) and LTR of the type 1 human immunodeficiency virus (HIV-1) involves the induced nuclear expression of NF-kappa B. We now report the identification of missense mutations within the tax gene that functionally segregate these two pathways of trans-activation. Additionally, we demonstrate that the carboxyl terminus of the Tax protein, despite its acidic and predicted alpha-helical structure, is completely dispensable for trans-activation through either of these transcription factor pathways. Finally, we demonstrate that mutations within a putative zinc finger domain disrupt the nuclear localization of Tax and abolish trans-activation. These results demonstrate that Tax trans-activation of viral and cellular promoters involves at least two mechanisms of host transcription factor activation and suggest that this activation is likely mediated through distinct functional domains.
Diode-pumped composite-cavity electro-optically tuned microchip laser (1993)

Microchip lasers1 have been frequency tuned using a variety of techniques including thermal tuning, piezoelectric tuning,2 and pumpdiode modulation.3 Each of these techniques provides frequency modulation at low excursion rates and has advantages for a given set of applications. However, for applications including frequency-modulated optical communications and chirped coherent laser radar, extremely high rates of tuning are required. These rates can only be achieved electro-optically.4 Composite-cavity electro-optically tuned microchip lasers provide linear voltage-to-frequency conversion with constant-, high-sensitivity tuning at rates from dc to several gigahertz. This, coupled with their simplicity, small size, robustness, high mode quality, and potential for low-cost mass production, should make them attractive for a large range of applications.