Pulmonary Aspergillosis, Inhalation of Contaminated Marijuana Smoke, Chronic Granulomatous Disease (1975)

Letters1 May 1975Pulmonary Aspergillosis, Inhalation of Contaminated Marijuana Smoke, Chronic Granulomatous DiseaseMICHAEL J. CHUSID, M.D., JEFFREY A. GELFAND, M.D., CATHY NUTTER, B.S., ANTHONY S. FAUCI, M.D.MICHAEL J. CHUSID, M.D., JEFFREY A. GELFAND, M.D., CATHY NUTTER, B.S., ANTHONY S. FAUCI, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-5-682 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIncreased susceptibility to infection is a hallmark of chronic granulomatous disease of childhood (1), an inherited disorder in which phagocytic cells are unable to kill certain types of ingested organisms (2). We present a case of Aspergillus fumigatus pneumonitis in a 17-year-old boy with chronic granulomatous disease, whose infection may have been acquired through inhalation of smoke from marijuana contaminated with fungi.A 17-year-old boy was admitted to the National Institutes of Health with fever and exertional dyspnea. Two weeks before admission, he noted the onset of malaise 12 hours after smoking several pipefulls of marijuana that had been buried...References1. GOODQUIEWINDHORST RPD: Fatal (chronic) granulomatous disease of childhood: a hereditary defect of leukocyte function. Semin Hematol 5:215-254, 1968 MedlineGoogle Scholar2. QUIEWHITEHOLMES PJB: In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood. J Clin Invest 46:668-679, 1967 CrossrefMedlineGoogle Scholar3. PINCUSKLEBANOFF SS: Quantitative leukocyte iodination. N Engl J Med 284:744-750, 1971 CrossrefMedlineGoogle Scholar4. WELTY R: Fungi isolated from flue-cured tobacco sold in Southeast United States, 1968-1970. Appl Microbiol 24:518-520, 1972 CrossrefMedlineGoogle Scholar5. MCCARTHYPEPYS DJ: Allergic bronchopulmonary aspergillosis. Clin Allergy 1:261-286, 1971 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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