gebhart/patrepeval huggingface dataset:
Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review (2016)

Notwithstanding the peculiar sensitivity to cisplatin-based treatment, resulting in a very high percentage of cures even in advanced stages of the disease, still we do not know the biological mechanisms that make Testicular Germ Cell Tumor (TGCT) "unique" in the oncology scene. p53 and MDM2 seem to play a pivotal role, according to several in vitro observations, but no correlation has been found between their mutational or expression status in tissue samples and patients clinical outcome. Furthermore, other players seem to be on stage: DNA Damage Repair Machinery (DDR) , especially Homologous Recombination (HR) proteins, above all Ataxia Telangiectasia Mutated (ATM), cooperates with p53 in response to DNA damage, activating apoptotic cascade and contributing to cell "fate". Homologous Recombination deficiency has been assumed to be a Germ Cell Tumor characteristic underlying platinum-sensitivity, whereby Poly(ADP-ribose) polymerase (PARP), an enzyme involved in HR DNA repair, is an intriguing target: PARP inhibitors have already entered in clinical practice of other malignancies and trials are recruiting TGCT patients in order to validate their role in this disease. This paper aims to summarize evidence, trying to outline an overview of DDR implications not only in TGCT curability, but also in resistance to chemotherapy.
Acetal‐Modified Dextran Microparticles with Controlled Degradation Kinetics and Surface Functionality for Gene Delivery in Phagocytic and Non‐Phagocytic Cells (2010)

A microparticulate gene delivery system based on biodegradable and acid-sensitive acetal-modified dextran with unprecedented tunability of degradation rates and simplicity of surface functionalization is presented. When optimally formulated with small amounts of cationic polymers, these microparticles are capable of efficiently transfecting both phagocytic and non-phagocytic cells with minimal toxicity.
COO: Comic Onomatopoeia Dataset for Recognizing Arbitrary or Truncated Texts (2022)

Recognizing irregular texts has been a challenging topic in text recognition. To encourage research on this topic, we provide a novel comic onomatopoeia dataset (COO), which consists of onomatopoeia texts in Japanese comics. COO has many arbitrary texts, such as extremely curved, partially shrunk texts, or arbitrarily placed texts. Furthermore, some texts are separated into several parts. Each part is a truncated text and is not meaningful by itself. These parts should be linked to represent the intended meaning. Thus, we propose a novel task that predicts the link between truncated texts. We conduct three tasks to detect the onomatopoeia region and capture its intended meaning: text detection, text recognition, and link prediction. Through extensive experiments, we analyze the characteristics of the COO. Our data and code are available at \url{https://github.com/ku21fan/COO-Comic-Onomatopoeia}.
An Integrated Heater Equalizer for Lithium-Ion Batteries of Electric Vehicles (2018)

In this paper, an automotive onboard heater equalizer is proposed to heat low-temperature batteries and balance cell voltages without the requirement of external power supplies. The proposed integrated topology only needs one MOSFET for one cell, resulting in a compact size and low cost, which can be easily applied to electric vehicles. In particular, all MOSFETs are driven by one high-frequency pulsewidth modulation signal and the batteries can be heated internally by the ohmic and electrochemical losses and warmed externally by the switching and conduction losses of MOSFETs, leading to a high heating speed and efficiency. Further, a thermoelectric model for the internal and external combined heating is developed to provide guidance for the optimized design of the proposed heater. In addition, the proposed topology can realize passive balancing of series-connected battery strings at a higher switching frequency and a smaller duty cycle. Experimental results show that the proposed heater, by generating a periodic ramped discharge current with an rms value of 1.8 C at a switching frequency of 150 kHz, can heat the lithium-ion batteries from -20 to 0 °C within 1.9 min, consuming about 5% of the cell energy.
Specification and judging of high speed rotating machinery with AMB - A practical guideline for OEMS, EPC and end users (2012)

This paper is focused on practical questions arising when purchasing or specifying high speed rotating machines with active magnetic bearings (AMB). It may be used as a guideline for end users, engineering/ procurement/construction (EPC) companies and original equipment manufacturers (OEM) in their engineering and their purchase departments. The paper explains and discusses the most important characteristics of AMB systems as well as the necessary documents of the vendor to prove feasibility of the AMB application. The authors' intention is to bring the AMB technology down from the highly technical discussion among specialists to the level of general understanding for every engineer or person with technical background.
Preparation of Enantiopure 2,2,5,5-Tetramethyl-3,4-hexanediol and Its Use in Catalytic Enantioselective Oxidation of Sulfides to Sulfoxides (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTPreparation of Enantiopure 2,2,5,5-Tetramethyl-3,4-hexanediol and Its Use in Catalytic Enantioselective Oxidation of Sulfides to SulfoxidesYoshinori Yamanoi and Tsuneo ImamotoView Author Information Department of Chemistry, Faculty of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263, JapanCite this: J. Org. Chem. 1997, 62, 24, 8560–8564Publication Date (Web):November 28, 1997Publication History Received4 June 1997Published online28 November 1997Published inissue 1 November 1997https://pubs.acs.org/doi/10.1021/jo971004yhttps://doi.org/10.1021/jo971004ybrief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views902Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alkyls,Diols,Oxidation,Oxides,Sulfides Get e-Alerts
Micromagnetics of submicron (110) Fe elements (2000)

The magnetization processes and the domain structure of epitaxial (110) Fe submicron-sized elements are studied experimentally and with micromagnetic simulations. Magnetic force microscopy and Kerr magnetometry results are in good agreement with the simulations, thus allowing the development of a consistent picture of the micromagnetics of these systems.
Expression of Sirtuin 1 and 2 Is Associated with Poor Prognosis in Non-Small Cell Lung Cancer Patients (2015)

Our results support the hypothesis that SIRT1 and SIRT2 have a protumorigenic role in lung cancer, promoting cell proliferation. Moreover, the expression of these proteins is associated with poor prognosis in NSCLC patients and may help to identify those NSCLC patients with high risk of recurrence that could benefit from adjuvant therapy after resection.
Corrosion Evolution in Al/Steel Dissimilar Joints (2020)

Abstract Al/steel joints are increasingly used in the automotive industry to meet the requirement of energy saving and emission reduction. Among various joining technologies, self-pierce riveting (SPR) and resistance spot welding (RSW) are two promising technologies to fabricate dissimilar joints with stable and high mechanical performance. However, corrosion will occur in these joints inevitably due to different electrochemical properties, which can degrade the surface quality and the mechanical performance, including strength, ductility, etc. In this paper, 1.2 mm AA6022 and 2.0mm HDG HSLA340 are joined by SPR and RSW. After the fabrication of these Al/steel joints, cyclic corrosion tests are performed, which lasts 26 cycles and 48 cycles. By comparing the microstructure of the joints with and without corrosion, different corrosion mechanisms in SPR and RSW are revealed, including the corrosion initiation and propagation.
A Copper-Catalyzed N-Alkynylation Route to 2-Substituted N-Alkynyl Pyrroles and Their Cyclization into Pyrrolo[2,1-c]oxazin-1-ones: A Formal Total Synthesis of Peramine (2017)

Screening of a variety of ligands and reaction conditions for the copper-catalyzed cross-coupling of alkynyl bromides with pyrroles, reveals that the use of the phenanthroline ligand 4,7-dimethoxy-1,10-phenanthroline affords a range of ynpyrroles in good to moderate yields. Furthermore, the utility of these ynpyrroles is demonstrated in the preparation of a series of pyrrolo[2,1-c][1,4]oxazin-1-ones and a formal total synthesis of the pyrrole natural product peramine.
A 20-MS/s to 40-MS/s Reconfigurable Pipeline ADC Implemented With Parallel OTA Scaling (2010)

A reconfigurable 12-b pipeline analog-to-digital converter (ADC) implemented by enabling or disabling MDAC OTAs in parallel is presented. Power scaling is achieved without varying the dc bias conditions of critical analog nodes, reducing design complexity, and allowing an existing design to be rapidly reconfigured for new specifications. The ADC can be designed for optimal power consumption over the entire sampling rate range due to the linear power scaling provided by the parallel OTA approach. The proposed ADC operates over a sampling rate range of 20 MS/s to 40 MS/s with <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$&gt;$</tex></formula> 62 dB SNDR. The analog power varies linearly from 36 mW at 20 MS/s to 72 mW at 40 MS/s. The ADC was fabricated in 0.18- <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\mu\hbox{m}$</tex></formula> CMOS process and occupies a die area of 1.9 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\hbox{mm}^{2}$</tex></formula> .
Contribution à 1′étude des acides de CLEVE Le système quinaire Na+‐M++‐amino‐1‐naphtalène‐sulfonate‐6‐amino‐1‐naphtalène‐sulfonate‐7‐C1−‐H2O entre 0° et 75° (1968)

Abstract The solubility diagram of the quinary system Na + ‐Mg ++ ‐1‐anminonaphtalene‐6‐sulfonate‐1‐aminonaphtalene‐7‐sulfonate‐Cl − ‐H 2 O has been partially investigated between 0° and 75°. From this diagram a simple and effective procedure to separate the two C LEVE'S acids has been calculated, with yields in acid 1.7 (extracted as sodium salt) of 95.1% and in acid 1.6 (obtained as magnesium salt) of 70.0%. This theoretical procedure was adapted to the fraction of a crude industrial mixture of C LEVE 's acids.
Sequence of the FRA3B common fragile region: Implications for the mechanism of FHIT  deletion (1997)

The hypothesis that chromosomal fragile sites may be "weak links" that result in hot spots for cancer-specific chromosome rearrangements was supported by the discovery that numerous cancer cell homozygous deletions and a familial translocation map within the FHIT gene, which encompasses the common fragile site, FRA3B. Sequence analysis of 276 kb of the FRA3B/FHIT locus and 22 associated cancer cell deletion endpoints shows that this locus is a frequent target of homologous recombination between long interspersed nuclear element sequences resulting in FHIT gene internal deletions, probably as a result of carcinogen-induced damage at FRA3B fragile sites.
Evaluation of the Effect of Cement Viscosity on Cement Mantle in Total Knee Arthroplasty (2008)

Aseptic loosening of the tibial implant remains one of the major reasons of failure in Total Knee Arthroplasty (TKA). The cement viscosity at the time of application to the bone is of great importance to ensure a long-term success of the arthroplasty, as it influences the cement penetration and stability of the prosthesis. Currently, there are number of cements available with a wide range of viscosities and set times. High viscosity faster-setting cements may significantly reduce operating room times. However, the concern is that this positive feature may be at the expense of decreased penetration into the bone, and hence reduced stability of the construct. The use of four cement types ((DePuy II (DePuy Inc. Warsaw, IN), Endurance (DePuy Inc. Warsaw, IN), Simplex-P (Stryker Corp Kalamazoo, MI), and Palacos (Zimmer, Inc, Warsaw, IN)) were compared and evaluated during TKA using surrogate tibiae, with respect to the depth of cement penetration according to the Knee Society Total Knee Arthroplasty Roentgenographic Evaluation System. On radiographic analysis of the implanted surrogate tibiae, it was found that Simplex had the maximum commulative penetration of 19.2 mm in seven zones in Mediolateral view, and 12.7 mm in three zones in anteroposterior view. In zone seven, the difference was statistically significant when comparing Simplex with Palacos (11 mm vs 4.6 mm, two-tailed P value = 0.035), somewhat significant with Depuy 2 (11 mm vs 6 mm, two tailed P value = 0.08), but the different was not significant when compared with Endurance (11 mm vs 10 mm, two-tailed P value = 0.6345). In Zone 5, the difference was statistically significant with Simplex vs Endurance (0.3 mm vs 2.2 mm, P = 0.028), and with Simplex vs Depuy 2 (0.3 mm vs 2.17 mm, P = 0.012). This study enhances the understanding of the relation between cement viscosities and cement penetration into cancellous bone during TKA.
Improving the voltage modulation depth and RF power generated on Nonlinear Transmission lines (2018)

Nowadays Nonlinear Transmission Lines-NLTL have been studied for RF generation to be applied in different systems of communications such as satellite, military and biomedical applications. NLTL is built by using a network composed by inductors and capacitors, where at least one of these components need to have a nonlinear behavior. One limiting factor for applications is in the peak power range, and a way to increasing this is improving voltage modulation depth -VMD, which is main goal of this work. In this work, it is simulated and built three configurations of NLTLs using ceramic capacitors to improve VMD and consequently the RF power generated at the output. As shown by the results the cross-link configuration is the best method due to the highest VMD generated.
Improvement of phase noise in a widely tunable optoelectronic oscillator based on balanced detection (2015)

A widely tunable optoelectronic oscillator based on balanced detection is proposed and experimentally demonstrated. A frequency tunable range from 4 GHz to 16 GHz is achieved. The phase noise of the generated signal is reduced to about −105 dBc/Hz.
The relationship between intra-parenchymal renal resistive index variation and renal functional reserve in healthy subjects (2020)

The IRRIV test is an ultrasound technique that significantly predicts the presence and the degree of renal functional reserve in healthy subjects.
The stability of liquid‐filled matrix ionization chamber electronic portal imaging devices for dosimetry purposes (2004)

This study was performed to determine the stability of liquid-filled matrix ionization chamber (LiFi-type) electronic portal imaging devices (EPID) for dosimetric purposes. The short- and long-term stability of the response was investigated, as well as the importance of factors influencing the response (e.g., temperature fluctuations, radiation damage, and the performance of the electronic hardware). It was shown that testing the performance of the electronic hardware as well as the short-term stability of the imagers may reveal the cause of a poor long-term stability of the imager response. In addition, the short-term stability was measured to verify the validity of the fitted dose-response curve immediately after beam startup. The long-term stability of these imagers could be considerably improved by correcting for room temperature fluctuations and gradual changes in response due to radiation damage. As a result, the reproducibility was better than 1% (1 SD) over a period of two years. The results of this study were used to formulate recommendations for a quality control program for portal dosimetry. The effect of such a program was assessed by comparing the results of portal dosimetry and in vivo dosimetry using diodes during the treatment of 31 prostate patients. The improvement of the results for portal dosimetry was consistent with the deviations observed with the reproducibility tests in that particular period. After a correction for the variation in response of the imager, the average difference between the measured and prescribed dose during the treatment of prostate patients was -0.7%+/-1.5% (1 SD), and -0.6%+/-1.1% (1 SD) for EPID and diode in vivo dosimetry, respectively. It can be concluded that a high stability of the response can be achieved for this type of EPID by applying a rigorous quality control program.
Faster, cheaper and under control: de-risking CMC development with transposon-derived manufacturing cell lines (2020)

The development of highly productive, genetically stable manufacturing cell lines is on the critical path to IND filing for protein based biologic drugs. Here we describe Leap-In Transpoasase® platform, a novel transposon-based mammalian (e.g. CHO) cell line development system that produces high titer stable pools with productivity and product quality attributes that are highly comparable to clones that are subsequently derived therefrom. The productivity distributions of clones are strongly biased towards high producers and both genetic and expression stability is consistently high. By avoiding the poor integration rates, concatemer formation, detrimental transgene recombination, low average expression level, unpredictable product quality and inconsistent genetic stability characteristic of non-homologous recombination methods, Leap-In provides several opportunities to de-risk programs early and reduce timelines and resources.
Hydrodynamic resistance of confined cells in rectangular microchannels (2011)

In the title compound, [CrCl(2)(C(3)H(10)N(2))(2)]ClO(4), the Cr(III) atom is coordinated equatorially by four N atoms of two propane-1,3-diamine (tn) ligands and axially by two mutually trans Cl atoms, thus displaying a slightly distorted octa-hedral geometry with no crystallographically imposed symmetry. The two six-membered chair chelate rings in the complex cation are in an anti conformation with respect to each other. The Cr-N bond lengths range from 2.0831 (18) to 2.0917 (19) Å, and the Cr-Cl bond lengths are 2.3148 (6) and 2.3135 (6) Å. The perchlorate anions have slightly distorted tetra-hedral geometries. Weak inter-molecular hydrogen bonds involving the tn ligand NH groups as donors, and chloride ligands and anion O atoms as acceptors are observed.
Nucleotide sequence of the rhamnose biosynthetic operon of Shigella flexneri 2a and role of lipopolysaccharide in virulence (1994)

N1308, a chromosomal Tn5 mutant of Shigella flexneri 2a, was described previously as a lipopolysaccharide (LPS) mutant with a short O side chain. N1308 formed foci, but not plaques, in LLC-MK2 cell monolayers and was negative in the Serény test. In this study, the wild-type locus inactivated in N1308 was cloned and further defined by means of complementation analysis. A 4.3-kb BstEII-XhoI fragment of S. flexneri 2a YSH6200 DNA was sufficient to restore both normal LPS and virulence phenotype to the mutant. DNA sequencing of this region revealed four genes, rfbA, rfbB, rfbC, and rfbD, encoding the enzymes required for the biosynthesis of activated rhamnose. The four genes were expressed in Escherichia coli, and the expected protein products were visualized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. N1308 was shown to have normal levels of surface IpaC and IpaD, while a Western blot (immunoblot) of whole-cell lysates or outer membrane fractions indicated an elevated level of appropriately localized VirG. An in vitro invasion assay revealed that N1308 had normal primary invasive capacity and was able to multiply and move normally within the initial infected cell. However, it exhibited a significant reduction in its ability to spread from cell to cell in the monolayer. A double immunofluorescence assay revealed differences between LLC-MK2 cells infected with the wild-type YSH6000 and those infected with N1308. The wild-type bacteria elicited the formation of the characteristic F-actin tails, whereas N1308 failed to do so. However, N1308 was capable of inducing deposition of F-actin, which accumulated in a peribacterial fashion with only slight, if any, unipolar accumulation of the cytoskeletal protein.
Osteocalcin promotes differentiation of osteoclast progenitors from murine long‐term bone marrow cultures (1994)

Murine long-term bone marrow cultures (LTBMCs) were used to generate hematopoietic cells free from marrow stromal cells. These progenitor cells were treated with GM-CSF (5 U/ml) with or without rat bone osteocalcin or rat serum albumin in either alpha-MEM with 2% heat-inactivated horse serum alone (alpha) or supplemented with 10% L-cell-conditioned medium (as a source of M-CSF) (L10). Few substrate-attached cells survived in basal alpha medium, but when treated with L10 medium or GM-CSF, they survived and proliferated. Osteocalcin did not significantly affect survival or proliferation. Subcultures of cells treated with GM-CSF had large numbers of multinucleated cells, more than half of which were tartrate-resistant acid phosphatase-positive (TRAP). Osteocalcin further promoted the development of TRAP-positive multinucleated cells; a dose of 0.7 microgram/ml osteocalcin promoted osteoclastic differentiation by 60%. Using a novel microphotometric assay, we detected significantly more tartrate-resistant acid phosphatase activity in the osteocalcin plus GM-CSF group (75.6 +/- 14.2) than in GM-CSF alone (53.3 +/- 7.3). In the absence of M-CSF, GM-CSF stimulated tartrate-resistant acid phosphatase activity, but osteocalcin did not have an additional effect. These studies indicate that osteocalcin promotes osteoclastic differentiation of a stromal-free subpopulation of hematopoietic progenitors in the presence of GM-CSF and L-cell-conditioned medium. These results are consistent with the hypothesis that this bone-matrix constituent plays a role in bone resorption.