gebhart/patrepeval huggingface dataset:
Preserving Privacy in Personalized Models for Distributed Mobile\n Services (2021)

The ubiquity of mobile devices has led to the proliferation of mobile\nservices that provide personalized and context-aware content to their users.\nModern mobile services are distributed between end-devices, such as\nsmartphones, and remote servers that reside in the cloud. Such services thrive\non their ability to predict future contexts to pre-fetch content or make\ncontext-specific recommendations. An increasingly common method to predict\nfuture contexts, such as location, is via machine learning (ML) models. Recent\nwork in context prediction has focused on ML model personalization where a\npersonalized model is learned for each individual user in order to tailor\npredictions or recommendations to a user's mobile behavior. While the use of\npersonalized models increases efficacy of the mobile service, we argue that it\nincreases privacy risk since a personalized model encodes contextual behavior\nunique to each user. To demonstrate these privacy risks, we present several\nattribute inference-based privacy attacks and show that such attacks can leak\nprivacy with up to 78% efficacy for top-3 predictions. We present Pelican, a\nprivacy-preserving personalization system for context-aware mobile services\nthat leverages both device and cloud resources to personalize ML models while\nminimizing the risk of privacy leakage for users. We evaluate Pelican using\nreal world traces for location-aware mobile services and show that Pelican can\nsubstantially reduce privacy leakage by up to 75%.\n
Pd-induced ordering of 2D Pt nanoarrays on phosphonated calix[4]arenes stabilised graphenes (2011)

p-Phosphonic acid calix[4]arenes render high stability to exfoliated graphenes in water. These calix[4]arenes modified graphenes can be used as highly effective substrates to nucleate ultra-small Pd nanoparticles, which in turn serve as galvanic reaction templates for the generation of high density 2D arrays of Pt nanoparticles.
Successful induction of immune responses against mutant ras in melanoma patients using intradermal injection of peptides and GM‐CSF as adjuvant (2001)

The rapidly increasing incidence and mortality rate of malignant melanoma, together with the lack of efficient treatment of the late stages, makes it a serious threat to public health. Innovative new treatments are needed. The proteins of the ras-family of proto-oncogenes, functioning as relay switches for signalling pathways between cell surface and nucleus, are involved in cell proliferation, differentiation, apoptosis and transformation. If over-expressed or mutated they can induce and/or maintain a transformed state of a cell. Codon 61 mutations of N-ras seem to be involved in melanoma development on sun exposed sites. In order to induce an immune response towards mutated N-ras proteins we performed a phase 1 feasibility study. Ten melanoma patients were immunized intradermally 6 times with N-ras peptides (residue 49-73) with 4 codon 61 mutations using GM-CSF as adjuvant. HLA typing was not used as an inclusion criterion. Eight patients responded with strong delayed type hypersensitivity reactions. In 2 of the patients an in vitro response to the vaccine could also be detected. The specificity of the reaction could be confirmed by cloning of peptide-specific CD4 positive T cells from peripheral blood of the patients. Intradermal injection of ras peptides using GM-CSF as adjuvant is simple to perform and seems to be efficient in inducing cellular immune responses. Since a majority of the patients showed positive skin reactions and 2 of the patients analysed showed a T-helper response to this melanoma specific antigen, these promiscuous HLA class II binding mutant ras peptides may be candidates for inclusion into vaccine cocktails containing various established CTL epitopes.
N6-Bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN6-Bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptorB. K. Trivedi, A. J. Bridges, W. C. Patt, S. R. Priebe, and R. F. BrunsCite this: J. Med. Chem. 1989, 32, 1, 8–11Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/jm00121a002https://doi.org/10.1021/jm00121a002research-articleACS PublicationsRequest reuse permissionsArticle Views143Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Stage-specific Plasmodium falciparum immune responses in afebrile adults and children living in the Greater Accra Region of Ghana (2020)

The pattern of antibody responses measured in people living in the high and low malaria transmission setting was similar. All antibody responses measured against the asexual antigen MSP3 increased, however, IgG and IgG1 responses against gametocyte antigen Pfs230 decreased in moving from the dry to the peak season in both sites. Whilst asexual and gametocyte prevalence was similar between the seasons in the low transmission setting, in the high transmission setting asexual parasite prevalence increased but gametocyte prevalence decreased in the rainy season relative to the dry season.
Coprime conditions for Fourier sampling for sparse recovery (2014)

This paper considers the spark of L × N submatrices of the N × N Discrete Fourier Transform (DFT) matrix. Here a matrix has spark m if every collection of its m - 1 columns are linearly independent. The motivation comes from such applications of compressed sensing as MRI and synthetic aperture radar, where device physics dictates the measurements to be Fourier samples of the signal. Consequently the observation matrix comprises certain rows of the DFT matrix. To recover an arbitrary k-sparse signal, the spark of the observation matrix must exceed 2k + 1. The technical question addressed in this paper is how to choose the rows of the DFT matrix so that its spark equals the maximum possible value L + 1. We expose certain coprimeness conditions that guarantee such a property.
Treatment of Stage IA Nodular Lymphocyte-Predominant Hodgkin Lymphoma (NLPHL): An Analysis from the German Hodgkin Study Group (GHSG) (2014)

Abstract Introduction: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma entity accounting for about 5% of all HL cases. As compared with classical HL (cHL), NLPHL is characterized by the absence of CD30 and the consistent expression of CD20 on the malignant lymphocyte predominant (LP) cells. Given a more indolent clinical course, especially early-stage NLPHL is often treated less aggressive than classical HL (cHL). In stage IA patients, radiotherapy (RT) alone is applied at most institutions. However, this clinical practice is not based on data from prospective clinical trials with sufficient follow-up. To shed more light on the optimal treatment of stage IA NLPHL, we performed an analysis including patients with long-term follow-up treated within German Hodgkin Study Group (GHSG) clinical trials. Patients: A total of 256 stage IA NLPHL patients treated within 7 prospective GHSG studies between 1988 and 2009 were included in the analysis. Treatment consisted of combined-modality treatment (CMT) (n=72), extended-field RT (EF-RT) (n=49), involved-field RT (IF-RT) (n=108) or four weekly doses of the anti-CD20 antibody rituximab (n=27). Results: The median age at NLPHL diagnosis was 38.5 years (range: 17-75); 194/256 (75.8%) patients were male and 62/256 (24.2%) patients were female. Median follow-up for the whole patient group was 91 months (98 months for CMT, 118 months for EF-RT, 87 months for IF-RT, 49 months for rituximab). All patients responded to treatment irrespective of the treatment modality applied. At 8 years, progression-free survival (PFS) and overall survival (OS) rates were 88.5% and 94.5% for CMT, 84.3% and 95.7% for EF-RT and 91.9% and 99.0% for IF-RT; 4-year PFS and OS rates for patients treated with rituximab were 81.0% and 100%. Seventeen patients developed a second malignancy in the course of follow-up (8 after CMT, 3 after EF-RT, 4 after IF-RT, 2 after rituxmab). Nine of these second malignancies were solid tumors (4 after CMT, 2 after EF-RT, 1 after IF-RT, 2 after rituximab) and 8 were hematologic malignancies (4 after CMT, 1 after EF-RT, 3 after IF-RT, none after rituximab). A total 12 deaths occurred. The most common cause of death was cardiac failure (n=3). Only one patient died from NLPHL. Conclusion: Based on this large analysis with long-term follow-up, IF-RT should be the standard of care for stage IA NLPHL. Treatment with single agent rituximab is associated with an increased event rate when compared with IF-RT and should therefore not be routinely used in stage IA NLPHL patients. However, given the shorter follow-up in comparison with CMT, EF-RT and IF-RT, final conclusions regarding rituximab especially in terms of treatment-related late sequelae cannot yet be drawn. Addition of chemotherapy does not improve the excellent outcome achieved with RT alone. Disclosures Off Label Use: Rituximab in NLPHL.
A 65 nm CMOS 30 dBm Class-E RF Power Amplifier With 60% PAE and 40% PAE at 16 dB Back-Off (2009)

A 30 dBm single-ended class-E RF power amplifier (PA) is fabricated in a baseline 65 nm CMOS technology. The PA is constructed as a cascode stage formed by a standard thin-oxide device and a dedicated novel high voltage extended-drain thick-oxide device. Both devices are implemented without using additional masks or processing steps. The proposed PA uses an innovative self-biasing technique to ensure high power-added efficiency (PAE) at both high output power (P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</sub> ) and power back-off levels. At 2 GHz, the PA achieves a PAE of 60% at a Pout of 30 dBm and a PAE of 40% at 16 dB back-off. Stress tests indicate the reliability of both the novel high voltage device and the design.
Erratum to “A 3-Mbps, 802.11g-Based EMG Recording System With Fully Implantable 5-Electrode EMG Acquisition Device” [Aug 20 889-902] (2020)

Corrections were made to the title in the above named paper.
Heinz Heinemann’s Legacy at ExxonMobil: An Illustrious Career in Industrial Catalysis (2009)

Heinz Heinemann contributed significantly to the field of heterogeneous catalysis over his 60 year career. As a scientist and later Catalysis Research Manager at ExxonMobil’s (then Mobil’s) Princeton Laboratory, he oversaw the development of many of the ZSM-5 processes for fuels and chemicals, most notably, a post-reforming process known as M-Forming. The M-Forming process development program justified Mobil’s commercial development of ZSM-5, which in turn led to the rapid development of many other ZSM-5 processes including Methanol-to-Gasoline, Middle Distillate Dewaxing, xylene isomerizaion, and lubes dewaxing.
Insights Into the Spatiotemporal Patterns of Complexity of Ventricular Fibrillation by Multilead Analysis of Body Surface Potential Maps (2020)

Multilead BSPM analysis underlines distinct degrees of VF complexity based on substrate characteristics.
Design of linear phase M-channel perfect reconstruction FIR filter banks (1997)

We propose two approaches to design M channel nonparaunitary filter banks that satisfy perfect reconstruction (PR) and linear phase (LP) properties. In the first approach, the PR condition is imposed on only a high-pass filter. Although this method does not require nonlinear optimization, it has a demerit in that the order of a high-pass filter becomes high. In the second approach, two filters are optimized simultaneously using a Lagrange-Newton method. We can design PR filter banks that have the same length. The PR constraint is also formulated as a linear and nonlinear equation of the analysis filter coefficients. Finally, some design examples are included.
Growth and Development of GaInAsP for Use in High-Efficiency Solar Cells: Final Subcontract Report, 1 July 1991 - 30 December 1993 (1994)

This report describes accomplishments during Phase 3 of this subcontract. The overall goals of the subcontract were (1) to develop the necessary technology to grow high-efficiency GaInAsP layers that are lattice-matched to GaAs and Ge; (2) to demonstrate highefficiency GaInAsP single-junction solar cells; and (3) to demonstrate GaInAsP/Ge cascade solar cells suitable for operation under concentrated (500X) sunlight. The major accomplishments during Phase 3 include (1) demonstrating a GaInAsP tunnel diode for use as an interconnect in the GaInAsP/Ge cascade cell, and (2) demonstrating a GaInAsP/Ge cascade cell. The development of the GaInAsP tunnel diode is a major accomplishment because it allows for the GaInAsP and Ge cells to be connected without optical losses for the bottom Ge cell, such as a Ge tunnel diode would cause. The GaInAsP/Ge cascade cell development is significant because of the demonstration of a cascade cell with a new materials system.
Statistical restoration for robust and secure steganography (2005)

We investigate data hiding techniques that attempt to defeat steganalysis by restoring the statistics of the composite image to resemble that of the cover. The approach is to reserve a number of host symbols for statistical restoration: host statistics perturbed by data embedding are restored by suitably modifying the symbols from the reserved set. While statistical restoration has broad applicability to a variety of hiding methods, we illustrate our ideas here for quantization index modulation (QIM) based hiding. We propose a method for significantly reducing the detectability of QIM, while preserving its robustness to attacks. We next use the framework of statistical restoration to develop a method to combat steganalysis techniques which detect block-DCT embedding by evaluating the increase in blockiness of the image due to hiding. Numerical results demonstrating the efficacy of these techniques are provided.
Characterization and prognostic implication of delayed complete response in AL amyloidosis (2020)

This study characterizes delayed CR in AL amyloidosis, highlights its prognostic impact which is at least similar to those who achieved CR at EOT, and underlines another aspect of response monitoring.
Sample Preparation and Profiling: Probing the Kinome for Biomarkers and Therapeutic Targets: Peptide Arrays for Global Phosphorylation-Mediated Signal Transduction (2013)

There is a growing appreciation of the intimate relationship between protein kinase activities and human health. Cellular kinases, individually or as a collective unit (the kinome), perform indispensable roles in regulating complex biology, underlie many disease states, and represent high-priority drug targets. Recent trends of drug development, where kinase inhibitors are becoming increasingly common, highlight the potential therapeutic opportunities made available through kinase investigations. There is also considerable evidence that understanding cellular responses at the level of kinase activity has the potential to reveal complex biology as well as identify biomarkers and therapeutic targets. With these appreciations, there is growing interest in the development of technologies that enable high-throughput characterization of kinome activity. Of these emerging technologies peptide arrays are proving a robust and adaptable tool for kinome characterizations.
Suzuki–Miyaura Cross-Coupling of Potassium Dioxolanylethyltrifluoroborate and Aryl/Heteroaryl Chlorides (2013)

A robust and efficient protocol for the introduction of the dioxolanylethyl moiety onto various aryl and heteroaryl halides has been developed, providing cross-coupling yields up to 93%. Copper-catalyzed borylation of 2-(2-bromoethyl)-1,3-dioxolane with bis(pinacolato)diboron followed by treatment with potassium bifluoride provides the key organotrifluoroborate reagent.
Acoustic coupling between oral tract and diatonic harmonica: Recent observations (2002)

The diatonic harmonica is arguably one of the most ‘‘vocal’’ of all reed instruments. Due to the relatively short distance, thus tight coupling, between the player’s oral cavity and the instrument, relatively subtle changes in the oral tract may effect dramatic modulations of both frequency and spectral content of the sound produced. Over the past several years we have endeavored to improve the understanding of this interaction, as well as the coupling between reeds of a given cell. This presentation will discuss our most recent observations. Benchtop experiments were conducted by laser vibrometer to measure the simultaneous motion of the reeds. Studies on human subjects were based on x-ray, ultrasonographic, and laryngoscopic imaging of players while sounding notes on the harmonica. Evidence of torsional instability has been observed, and analyzed by subsequent computational fluid dynamics simulation.
A novel synthesis of 6′′‐[18F]‐fluoromaltotriose as a PET tracer for imaging bacterial infection (2018)

The aim of this study was to develop a positron emission tomography (PET) tracer to visualize and monitor therapeutic response to bacterial infections. In our continued efforts to find maltose based PET tracers that can image bacterial infections, we have designed and prepared 6′′‐[ 18 F]fluoromaltotriose as a second generation PET imaging tracer targeting the maltodextrin transporter of bacteria. We have developed methods to synthesize 6′′‐deoxy‐6′′‐[ 18 F]fluoro‐α‐D‐glucopyranosyl‐(1‐4)‐O‐α‐D‐glucopyranosyl‐(1‐4)‐O‐D‐glucopyranose (6′′‐[ 18 F]‐fluoromaltotriose) as a bacterial infection PET imaging agent. 6′′‐[ 18 F]fluoromaltotriose was prepared from precursor, 2′′,3′′,4′′‐tri‐O‐acetyl‐6′′‐O‐nosyl‐α‐D‐glucopyranosyl‐(1‐4)‐O‐2′,3′,6′‐tri‐O‐acetyl‐α‐D‐glucopyranosyl‐(1‐4)‐1,2,3,6‐tetra‐O‐acetyl‐D‐glucopyranose (per‐O‐acetyl‐6′′‐O‐nosyl‐maltotriose 4 ). This method utilizes the reaction between precursor 4 and anhydrous [ 18 F]KF/Kryptofix 2.2.2 in dimethylformamide (DMF) at 85°C for 10 minutes to yield per‐O‐acetyl‐6′′‐deoxy‐6‐′′ [ 18 F]‐fluoromaltotriose ( 7) . Successive acidic and basic hydrolysis of the acetyl protecting groups in 7 produced 6′′‐[ 18 F]fluoromaltotriose ( 8 ). Also, cold 6′′‐ [ 19 F]fluoromaltotriose was prepared from per‐O‐acetyl‐6′′‐hydroxymaltotriose via a diethylaminosulfur trifluoride reaction followed by a basic hydrolysis. A successful synthesis of 6′′‐[ 18 F]‐fluoromaltotriose has been accomplished in 8 ± 1.2% radiochemical yield (decay corrected). Total synthesis time was 120 minutes. Serum stability of 6′′‐[ 18 F]fluoromaltotriose at 37°C indicated that 6′′‐[ 18 F]‐fluoromaltotriose remained intact up to 2 hours. In conclusion, we have successfully synthesized 6′′‐[ 18 F]‐fluoromaltotriose via direct fluorination of an appropriate precursor of a protected maltotriose.
<title>PermWeb: remote parallel and distributed-volume visualization</title> (1997)

In this paper we present a system for visualizing volume data from remote supercomputers. We have developed both parallel volume rendering algorithms, and the World Wide Web (WWW) software for accessing the data at the remote sites. The implementation uses Hypertext Markup Language, Java, and Common Gateway Interface scripts to connect WWW servers/clients to our volume renderers. The front ends are interactive Java classes for specification of view, shading , and classification inputs. We present performance results, and implementation details for connections to our computing resources at the University of California Santa Cruz including a MasPar MP-2, SGI Reality Engine-RE2, and SGI Challenge machines. We apply the system to the task of visualizing trabecular bone from finite element simulations. Fast volume rendering on remote compute servers through a web interface allows us to increase the accessibility of the results to more users. User interface issues, overview of parallel algorithm developments, and overall system interfaces and protocols are presented. Access is available through Uniform Resource Locator http://www.cse.ucsc.edu/research/slvg/.
Modulating and Switching Light on a Silicon Chip (2005)

Email Share Share with Facebook Share on X Post on reddit Share with LinkedIn Add to Mendeley Add to BibSonomy Share with WeChat Get Citation Copy Citation Text M. Lipson, "Modulating and Switching Light on a Silicon Chip," in Adaptive Optics: Analysis and Methods/Computational Optical Sensing and Imaging/Information Photonics/Signal Recovery and Synthesis Topical Meetings on CD-ROM, Technical Digest (Optica Publishing Group, 2005), paper IThB2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Exploiting common targets in human fertilization and HIV infection: development of novel contraceptive microbicides (2005)

The continued high rates of unintended pregnancies and the unrelentless expansion of the acquired immune deficiency syndrome (AIDS) epidemic, especially in less developed countries, warrant the development of novel strategies to help individuals avoid these risks. Dually active compounds displaying contraceptive and microbicidal anti-human immunodeficiency virus (anti-HIV) properties constitute one such strategy. Sharing the same anatomical and functional context, sperm fertilization and genital infection by HIV offer an opportunity for simultaneous intervention. Some of the molecules and mechanisms used by sperm to fertilize the oocyte are similar, if not identical, to those used by HIV while infecting host cells. An example of common structures is the lipid membrane surrounding the spermatozoon and the HIV core. Disruption of its architecture by surface-active compounds exerts both spermicidal and virucidal activity. A more specific alteration of lipid rafts [membrane microdomains enriched in cholesterol and glycosylphosphatidylinositol (GPI)-anchored proteins] by beta-cyclodextrins also results in similar effects. During fertilization and infection, both sperm and HIV interact with their target cell receptors through chemical charges, hydrophobic forces and carbohydrate recognition. Anionic polymers such as cellulose sulphate and polystyrene sulphonate (PSS) inhibit sperm and HIV cell binding. Because some of the molecules involved in this interaction, e.g. heparin sulphate proteoglycan, are also used by other pathogens to infect their target tissues, polyanions exert broad antimicrobial activity as well. During fertilization and infection, sperm and HIV, as well as other microbes, use signal transduction molecules and mechanisms such as adenyl cyclase/cyclic adenosine monophosphate (cAMP)-dependent kinase, calcium and tyrosine phosphorylation, whose inhibition has been shown to impair sperm function and HIV replication. These commonalities at the level of sperm and HIV structure, cell binding and fusion processes, and signalling pathways therefore provide the biological framework to develop bifunctional inhibitors with both antimicrobial and contraceptive properties.