gebhart/patrepeval huggingface dataset:
Experimental and Numerical Investigation of a Planar Combustor Sector at Realistic Operating Conditions (2000)

Results of an ongoing collaboration between the engine manufacturer MTU and the German aerospace research center DLR on the NOx reduction potential of conventional combustors are reported. A program comprising optical sector combustor measurements at 1, 6 and 15 bars and CFD calculations is carried out. The aims are to gather information in the combustor at realistic operating conditions, to understand the differences between the sector flow field and data from tubular combustors, to verify the used CFD and to discover the benefits and limitations of the applied optical diagnostics. Selected results of measurement and calculation of the isothermal flow and of measurements at 6 bars and 700 K at a rich-lean and overall lean AFR are reported. The used measurement techniques were LDA, PDA, Mie scattering on kerosene, Quantitative Light Scattering, OH* Chemiluminescence and LIF on OH. The measurements were able to confirm the intended quick and homogeneous mixing of the three staggered rows of secondary air jets.
In-process Monitoring and Control of Surface Roughness (1998)

&lt;div class="htmlview paragraph"&gt;This paper presents in-process monitoring and control based on a novel ultrasonic sensing technique. The developed ultrasonic system provides non-contact measurement of surface roughness, which is applicable to wet machining environments. The utility and robustness of the technique are demonstrated through applications to different processes and materials. In-process surface roughness monitoring capability of the system is also shown along with its potential to monitor flank wear conditions. The result of in-process surface roughness control implementation based on the developed technique shows the control scheme is able to maintain consistent surface roughness values regardless of the tool wear state.&lt;/div&gt;
Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort (2022)

Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease with a variable clinical course. Biomarkers that predict patient outcomes are needed. We leveraged data from 300 patients in the multicenter IPF-PRO Registry to determine associations between circulating proteins and the composite outcome of respiratory death or lung transplant. Plasma collected at enrollment was analyzed using aptamer-based proteomics (1305 proteins). Over a median follow-up of 30.4 months, there were 76 respiratory deaths and 26 lung transplants. In unadjusted univariable analyses, 61 proteins were significantly associated with the outcome (hazard ratio > 2 or < 0.5, corrected p ≤ 0.05). In multivariable analyses, a set of 4 clinical measures and 47 unique proteins predicted the probability of respiratory death or lung transplant with an optimism-corrected C-index of 0.76. Our results suggest that select circulating proteins strongly associate with the risk of mortality in patients with IPF and confer information independent of clinical measures.
Fiber Bragg Grating Demodulator Based on Hybrid Optical MEMS (2004)

This paper describes the design, experimental evaluation and performance results of a tunable optical filter based on hybrid microoptoelectromechanical systems (MOEMS) technology. The tunable filter can meet the demodulation requirements for Fiber Bragg grating (FBG) sensors. The hybrid system is built using an off-the-shelf 200-GHz dense wavelength-division multiplexing filter and a movable MEMS platform actuated by a thermal microactuator array fabricated with silicon-on-insulator multiuser MEMS processes. Results show a repeatable tuning range of over 400 pm, which satisfies the demodulation requirements for FBG sensors.
Herbal Substance, Acteoside, Alleviates Intestinal Mucositis in Mice (2015)

This study investigated the role of acteoside in the amelioration of mucositis. C57BL/6 mice were gavaged daily with acteoside 600 μg for 5 d prior to induction of mucositis and throughout the experimental period. Mucositis was induced by methotrexate (MTX; 12.5 mg/kg; s.c.). Mice were culled on d 5 and d 11 after MTX. The duodenum, jejunum, and ileum were collected for myeloperoxidase (MPO) activity, metallothionein (MT) levels, and histology. Acteoside reduced histological severity scores by 75, 78, and 88% in the duodenum, jejunum, and ileum, respectively, compared to MTX-controls on d 5. Acteoside reduced crypt depth by 49, 51, and 33% and increased villus height by 19, 38, and 10% in the duodenum, jejunum, and ileum, respectively, compared to MTX-controls on d 5. Acteoside decreased MT by 50% compared to MTX-control mice on d 5. Acteoside decreased MPO by 60% and 30% in the duodenum and jejunum, respectively, compared to MTX-controls on d 5. Acteoside alleviated MTX-induced small intestinal mucositis possibly by preventing inflammation.
An Implantable Port for Office Laparoscopy: The AbView Access Port (2008)

Due to the tendency of ovarian cancer to spread in small sections throughout the abdominal cavity, it is presently difficult to detect early stage cancer recurrence following the primary de-bulking of initial tumors. Because metastases may initially be isolated and too small to detect with conventional scanning techniques such as CT scan and MRI, direct laparoscopic examination of the peritoneal cavity is often conducted. At present, this must be performed in a full operating room, and with the patient under full anesthesia; as a result, such examinations are performed infrequently and at high costs. An implantable port has been designed which enables repeated access of a rigid tool such as a laparoscope to the abdominal cavity with only local anesthesia. The port consists of a tube and a suturing flange, inside of which is a tricuspid valve that prevents fluid backflow out of the peritoneal cavity, even at zero backpressure. The port is implanted through the abdominal wall and sutured to the fascia just below the skin at the time of the primary debulking. Then, when examination is necessary, a commercially available trocar can be inserted through the skin and fat under local anesthesia to interface with the port, thereby enabling all functionality of normal laparoscopic procedures with minimal impact to the patient. Thus, this device has the potential to enable rapid monitoring of metastases in an outpatient setting, and may also be used for drug delivery or biopsies.
iPSC-derived M2-like ALS macrophages suppress pro-Inflammatory phenotype of M1-like macrophages (S25.008) (2018)

To determine whether M2-like macrophages differentiated from human induced pluripotent stem cells (iPSC) are immune-suppressive and relevant mechanisms
A small molecule inhibitor against kinase domain of mammalian target of rapamycin (mTOR) causes autophagic cell death in glioblastoma (2008)

3365 Background: Autophagy is a process of intracellular bulk degradation whereby cellular proteins, organelles and cytoplasmic components are engulfed in double membrane forming autophagic vesicles, and delivered to the lysosomal system for subsequent degradation. Autophagy is regulated by phosphotidylinositol-3-kinases (PI3K) and mammalian target of rapamycin (mTOR) pathways. Activation of mTOR kinase has been shown to down-regulate autophagy process. Previous data indicated that autophagy could be induced by rapamycin as well as mTOR small interfering RNA (siRNA). Silencing of mTOR with siRNA augmented the cytotoxicity of rapamycin in glioblastoma, indicating that autophagy was a primary mediator of the anti-tumor effect of rapamycin rather than a protective response. The goals of this study were to determine whether a small molecule inhibitor against the kinase domain of mTOR would cause autophagic cell death. The secondary objective is to develop a high content screen assay for autophagy detection.  Methods: U-87 MG glioblastoma cells were treated with an mTOR specific kinase inhibitor. Inactivation of both mTOR complexes (TOR1 and TOR2) was evaluated by measuring phosphorylation of S6 Ser 235/236 and AKT Ser473 in cell lysates at indicated times. Autophagy was detected by fluorescent dye monodansylcadaverine (MDC) and acridine orange (AO) and confirmed by high content imaging assay with polyclonal antibody against LC3 (microtubule-associated protein 1 light chain 3), a specific biomarker for autophagy. The cleaved LC3-II protein was measured by western immunoblotting. Cell proliferation was measured by Alamar blue after 72 hours of treatment.  Results: Upon treatment of U-87 MG cells with mTOR kinase inhibitor for 48 hours, massive autophagy formation was observed in U-87 MG glioblastoma. Using high content imaging assay (Cellomics), the spots in the cytoplasm representing autophagic vesicles were increased in a dose-dependent manner. This correlated with an anti-proliferative effect. We also identified other compounds within the same series that possess a similar effect.  Conclusion:We demonstrate that an mTOR kinase inhibitor results in significant autophagic cell death in glioblastoma which correlates with the anti-proliferative effect suggesting the blockage of mTOR kinase activity initiates type II programmed cell death.
FaceDate: A Mobile Cloud Computing App for People Matching (2017)

This paper presents FaceDate, a novel mobile app that matches persons based on their facial looks. Each FaceDate user uploads their profile face photo and trains the app with photos of faces they like. Upon user request, FaceDate detects other users located in the proximity of the requester and per
Parameter Characterization for Elastic Energy Absorption of an Embedded Corrugated Wave Padding Concept (2016)

The parameters of an innovative padding concept were investigated using Finite Element Analyses (FEA) and physical testing. The concept relies on a compliant corrugation embedded in an elastic foam to provide stiffness for force distribution and elastic deformation for energy absorption. The shape of the corrugation cross section was explored as well as the wavelength and amplitude by employing a full factorial design of experiments. FEA results were used to choose designs for prototyping and physical testing. The results of the physical tests were consistent with the FEA predictions although the FEA tended to underestimate the peak pressure compared to the physical tests. A performance metric is proposed to compare different padding configurations. The concept shows promise for sports padding applications. It may allow for designs which are smaller, more lightweight, and move better with an athlete than current technologies yet still provide the necessary protective functions.
Presynaptic calcium is increased during normal synaptic transmission and paired-pulse facilitation, but not in long-term potentiation in area CA1 of hippocampus (1994)

We examined the relationship between presynaptic calcium levels and postsynaptic potentials during normal synaptic transmission, paired-pulse facilitation (PPF), and long-term potentiation (LTP) in CA3-CA1 synapses of hippocampus. By selectively loading the presynaptic terminals with the calcium indicator fura-2, we simultaneously recorded a presynaptic calcium (Ca) transient and the corresponding field EPSP evoked by a single stimulus given to the Schaffer collateral-commissural pathway in guinea pig hippocampal slices. A volume average presynaptic Ca influx was obtained by taking the first time derivative of the Ca transient. Our data indicate that the synaptic transmission represented by the initial slope of the field EPSP is approximately proportional to the fourth power of the presynaptic Ca influx, the volume average Ca current. Our results in combination with similar findings at the squid giant synapse (Augustine et al., 1985b; Augustine and Charlton, 1986) suggest that the relationship between Ca influx and transmitter release is well conserved from the molluscan to the mammalian nervous system. A transient increase of the residual Ca level ([Ca]res) is generally thought to be the mechanism underlying PPF (Katz and Miledi, 1968; Charlton et al., 1982); however, the relationship between PPF and the presynaptic [Ca]res had not been examined before. Our results demonstrate that PPF is approximately linearly related to the [Ca]res. This finding further supports the residual Ca hypothesis for PPF. Accumulated evidence from other groups suggests that the presynaptic site contributes to the maintenance of LTP in CA3-CA1 synapses (Bekkers and Stevens, 1990; Malinow and Tsien, 1990); however, our data show that neither an increase of the Ca transient nor a sustained increase of the [Ca]res occurs in the presynaptic terminals during maintenance of LTP. This suggests that the presynaptic mechanism underlying LTP must be downstream to Ca influx.
Correction to Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-d-aspartate Receptors (2014)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-d-aspartate ReceptorsRose M. Santangelo Freel, Kevin K. Ogden, Katie L. Strong, Alpa Khatri, Kathryn M. Chepiga, Henrik S. Jensen, Stephen F. Traynelis, and Dennis C. Liotta*Cite this: J. Med. Chem. 2014, 57, 11, 4975Publication Date (Web):May 30, 2014Publication History Published online30 May 2014Published inissue 12 June 2014https://doi.org/10.1021/jm500710wCopyright © 2014 American Chemical SocietyRequest reuse permissions This publication is free to access through this site. Learn MoreArticle Views667Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (111 KB) Get e-Alertsclose Get e-Alerts
Assessment and Extendibility of Chemically Amplified Resists for Extreme Ultraviolet Lithography: Consideration of Nanolithography beyond 22 nm Half-Pitch (2011)

The major resist properties, namely, resolution, line edge roughness (LER), and sensitivity have trade-off relationships. The relationships among them are determined by the pattern formation efficiency. Because of these trade-off relationships, the assessment of resist performance has been a difficult task. The extraction of parameters associated with pattern formation efficiency is important for the proper assessment of resist materials. In this study, we improved the resist model and analysis procedure for the parameter extraction and assessed state-of-the-art extreme ultraviolet (EUV) resists. Using extracted parameters, we evaluated the expected resist performance upon exposure to a next-generation exposure tool with high numerical aperture (NA). Furthermore, assuming the technical limits of resist materials, the extendibility of chemically amplified resists was examined. It was found that the resist requirements (10 mJ cm-2 sensitivity and 1 nm LER) for the 16 nm node are achievable at NA=0.35, although they were comparable to the assumed technical limit.
Robust Surface Reconstruction (2016)

We propose a method to reconstruct surfaces from oriented point clouds corrupted by errors arising from range imaging sensors. The core of this technique is the formulation of the problem as a convex minimization that reconstructs the indicator function of the surface's interior and substitutes the usual least-squares fidelity terms by Huber penalties to be robust to outliers, recover sharp corners, and avoid the shrinking bias of least-squares models. To achieve both flexibility and accuracy, we couple an implicit parametrization that reconstructs surfaces of unknown topology with adaptive discretizations that avoid the high memory and computational cost of volumetric representations. The hierarchical structure of the discretizations speeds minimization through multiresolution, while the proposed splitting algorithm minimizes nondifferentiable functionals and is easy to parallelize. In experiments, our model improves reconstruction from synthetic and real data, while the choice of discretization affects both the accuracy of the reconstruction and its computational cost.
Tissue expander placement and adjuvant radiotherapy after surgical resection of retroperitoneal liposarcoma offers improved local control (2016)

Given that retroperitoneal liposarcoma (LPS) is extremely difficult to completely resect, and has a relatively high rate of recurrence, radiotherapy (RT) is the treatment of choice after surgical resection. However, it is difficult to obtain a sufficient radiation field because of the close proximity of surrounding organs. We introduce the use of tissue expanders (TEs) after LPS resection in an attempt to secure a sufficient radiation field and to improve recurrence-free survival.This study is a retrospective review of 53 patients who underwent surgical resection of LPS at Samsung Medical Center between January 1, 2005, and December 31, 2012, and had no residual tumor detected 2 months postoperatively. The median follow-up period was 38.9 months.Patients were divided into 3 groups. Those in group 1 (n = 17) had TE inserted and received postoperative RT. The patients in group 2 (n = 9) did not have TE inserted and received postoperative RT. Finally, those in group 3 (n = 27) did not receive postoperative RT. Multivariate analysis was performed to identify the risk factors associated with recurrence-free survival within 3 years. Younger age, history of LPS treatment, and RT after TE insertion (group 1 vs group 2 or 3) were significantly favorable factors influencing 3-year recurrence-free survival.TE insertion after LPS resection is associated with increased 3-year recurrence-free survival, most likely because it allows effective delivery of postoperative RT.
IKBT: solving closed-form Inverse Kinematics with Behavior Tree (2017)

Serial robot arms have complicated kinematic equations which must be solved to write effective arm planning and control software (the Inverse Kinematics Problem). Existing software packages for inverse kinematics often rely on numerical methods which have significant shortcomings. Here we report a new symbolic inverse kinematics solver which overcomes the limitations of numerical methods, and the shortcomings of previous symbolic software packages. We integrate Behavior Trees, an execution planning framework previously used for controlling intelligent robot behavior, to organize the equation solving process, and a modular architecture for each solution technique. The system successfully solved, generated a LaTex report, and generated a Python code template for 18 out of 19 example robots of 4-6 DOF. The system is readily extensible, maintainable, and multi-platform with few dependencies. The complete package is available with a Modified BSD license on Github.
End-to-end simulations of the E-ELT/METIS coronagraphs (2016)

The direct detection of low-mass planets in the habitable zone of nearby stars is an important science case for future E-ELT instruments such as the mid-infrared imager and spectrograph METIS, which features vortex phase masks and apodizing phase plates (APP) in its baseline design. In this work, we present end-to-end performance simulations, using Fourier propagation, of several METIS coronagraphic modes, including focal-plane vortex phase masks and pupil-plane apodizing phase plates, for the centrally obscured, segmented E-ELT pupil. The atmosphere and the AO contributions are taken into account. Hybrid coronagraphs combining the advantages of vortex phase masks and APPs are considered to improve the METIS coronagraphic performance.
SpatialRugs: Enhancing Spatial Awareness of Movement in Dense Pixel Visualizations (2020)

Compact visual summaries of spatio-temporal movement data often strive to express accurate positions of movers. We present SpatialRugs, a technique to enhance the spatial awareness of movements in dense pixel visualizations. SpatialRugs apply 2D colormaps to visualize location mapped to a juxtaposed display. We explore the effect of various colormaps discussing perceptual limitations and introduce a custom color-smoothing method to mitigate distorted patterns of collective movement behavior.
Semiconductor Epitaxy in Superconducting Templates (2021)

Integration of high-quality semiconductor-superconductor devices into scalable and complementary metal-oxide-semiconductor compatible architectures remains an outstanding challenge, currently hindering their practical implementation. Here, we demonstrate growth of InAs nanowires monolithically integrated on Si inside lateral cavities containing superconducting TiN elements. This technique allows growth of hybrid devices characterized by sharp semiconductor-superconductor interfaces and with alignment along arbitrary crystallographic directions. Electrical characterization at low temperature reveals proximity induced superconductivity in InAs via a transparent interface.
Precision in imaging multivariate optical computing (2007)

Multivariate optical computing (MOC) is a method of performing chemical analysis using a multilayer thin-film structure known as a multivariate optical element (MOE). Recently we have been advancing MOC for imaging problems by using an imaging MOE (IMOE) in a normal-incidence geometry and employing normalization by the 1-norm. There are several important differences between the previously described 45° and the normal-incidence imaging, one of which is the measurement precision due to photon counting. We compare this precision to 45° MOC. We also discuss how MOE models with similar values of standard errors of calibration and prediction and similar gain values may vary in precision because of the sign or offset of the regression vector encoded in the IMOE spectrum. Experimental verification of a key result is provided by near-infrared imaging of slides coated with a dye-doped polymer film.