MP60-16 HYPOGONADISM IS ASSOCIATED WITH LOWER SPERM MORPHOLOGY AND LOWER LIVE BIRTH RATES IN MEN WITH UNEXPLAINED INFERTILITY (2018)

You have accessJournal of UrologyInfertility: Basic Research & Pathophysiology1 Apr 2018MP60-16 HYPOGONADISM IS ASSOCIATED WITH LOWER SPERM MORPHOLOGY AND LOWER LIVE BIRTH RATES IN MEN WITH UNEXPLAINED INFERTILITY JC Trussell, Robert Coward, Nanette Santoro, Christy Stetter, Allen Kunselman, Michael Diamond, Karl Hansen, Stephen Krawetz, Richard Legro, James Smith, Anne Steiner, Pasquale Patrizio, Robert Wild, Esther Eisenberg, Heping Zhang, and Mark Lindgren JC TrussellJC Trussell More articles by this author , Robert CowardRobert Coward More articles by this author , Nanette SantoroNanette Santoro More articles by this author , Christy StetterChristy Stetter More articles by this author , Allen KunselmanAllen Kunselman More articles by this author , Michael DiamondMichael Diamond More articles by this author , Karl HansenKarl Hansen More articles by this author , Stephen KrawetzStephen Krawetz More articles by this author , Richard LegroRichard Legro More articles by this author , James SmithJames Smith More articles by this author , Anne SteinerAnne Steiner More articles by this author , Pasquale PatrizioPasquale Patrizio More articles by this author , Robert WildRobert Wild More articles by this author , Esther EisenbergEsther Eisenberg More articles by this author , Heping ZhangHeping Zhang More articles by this author , and Mark LindgrenMark Lindgren More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.1908AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Sertoli cells thrive in an environment of high testosterone concentrations. Therefore, when subjected to low levels of testosterone, from any cause, abnormal spermatogenesis may occur. We performed a secondary analysis of a large, prospective clinical trial of couples with unexplained infertility to analyze whether sperm quality and pregnancy/live birth (LB) rates were associated with low total testosterone (TT). METHODS The Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) clinical trial was a prospective, randomized, multicenter clinical trial from the Reproductive Medicine Network investigating pregnancy, LB, and multiple pregnancy rates following ovarian-stimulated intrauterine inseminations for unexplained infertility. 900 couples were enrolled. In addition to a semen analysis (SA) (requiring ≥ 5 million total motile sperm), male partners completed endocrine testing and were subsequently followed for pregnancy and live birth rates. We performed logistic regression analyses to test the hypothesis that low TT is associated with low semen quality and lower pregnancy/LB rates. RESULTS 753 men (mean age 34.2 ±5.7 years) were included with a mean TT of 425.9 ±161.3 ng/dL. Baseline mean SA values include: volume 2.9 ±1.4 cc, concentration 67.0 ±64.5 M/cc, motility 55.9 ±14.8%, and morphology 13.7 ±14.3%. Low TT was defined as T <264 ng/dL. Although there was no association between low TT and sperm concentration <15 M/cc (odds ratio (OR) = 0.72, 95% confidence interval (CI) = (0.34, 1.56), p = 0.41) or motility <40% (OR = 1.30, 95% CI = (0.72, 2.32), p = 0.38); compared to men with TT >264, men with TT <264 were 1.8 times more likely to have low (<4% strict Kruger) morphology (OR = 1.79, 95% CI = (1.07, 2.97), p = 0.026).Moreover, in couples with a low TT partner, 20 (19.1%) had a LB, compared to 179 (27.6%) LB in couples with TT ≥264 ng/dL. The odds of LB decreased by 40% in couples with a low TT male partner (OR = 0.60, 95% CI = (0.36, 1.02), p = 0.057). CONCLUSIONS In couples with unexplained infertility having hypogonadal male partners with at least 5 million total motile sperm, low TT (< 264 ng/dL) was associated with low sperm morphology and a trend towards lower LB rates. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e796 Advertisement Copyright & Permissions© 2018MetricsAuthor Information JC Trussell More articles by this author Robert Coward More articles by this author Nanette Santoro More articles by this author Christy Stetter More articles by this author Allen Kunselman More articles by this author Michael Diamond More articles by this author Karl Hansen More articles by this author Stephen Krawetz More articles by this author Richard Legro More articles by this author James Smith More articles by this author Anne Steiner More articles by this author Pasquale Patrizio More articles by this author Robert Wild More articles by this author Esther Eisenberg More articles by this author Heping Zhang More articles by this author Mark Lindgren More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...