gebhart/patrepeval huggingface dataset:
Transfering spin into an extendedπorbital of a large molecule (2015)

By means of low-temperature scanning tunneling microscopy (STM) and spectroscopy (STS), we have investigated the adsorption of single Au atoms on a PTCDA monolayer physisorbed on the Au(111) surface. A chemical reaction between the Au atom and the PTCDA molecule leads to the formation of a radical that has an unpaired electron in its highest occupied orbital. This orbital is a $\ensuremath{\pi}$ orbital that extends over the whole Au-PTCDA complex. Because of the large Coulomb repulsion in this orbital, the unpaired electron generates a local moment when the molecule is adsorbed on the Au(111) surface. We demonstrate the formation of the radical and the existence of the local moment after adsorption by observing a zero-bias differential conductance peak that originates from the Kondo effect. By temperature dependent measurements of the zero-bias differential conductance, we determine the Kondo temperature to be ${T}_{\mathrm{K}}=(38\ifmmode\pm\else\textpm\fi{}8)\phantom{\rule{0.16em}{0ex}}\mathrm{K}$. For the theoretical description of the properties of the Au-PTCDA complex we use a hierarchy of methods, ranging from density functional theory (DFT) including a van der Waals correction to many-body perturbation theory (MBPT) and the numerical renormalization group (NRG) approach. Regarding the high-energy orbital spectrum, we obtain an excellent agreement with experiments by both spin-polarized DFT/MBPT and NRG. Moreover, the NRG provides an accurate description of the low-energy excitation spectrum of the spin degree of freedom, predicting a Kondo temperature very close to the experimental value. This is achieved by a detailed analysis of the universality of various definitions of ${T}_{\mathrm{K}}$ and by taking into account the full energy dependence of the coupling function between the molecule-metal complex and the metallic substrate.
Layout tools for analog ICs and mixed-signal SoCs (2000)

Layoutfor analog circuits has historically been a timeconsuming, manual, trial-and-error task. The problem is not so much the size (in terms of the number of active devices) of these designs, but rather the plethora of possible circuit and device interactions: from the chip substrate, from the devices and interconnects themselves, j?om the chip package. In this short survey we enumerate briefly the basic problems faced by those who need to do layout for analog and mixed-signal designs, and survey the evolution of the design tools and geometric/electrical optimization algorithms that have been directed at these problems.
A Th2 Chemokine, TARC, Produced by Trophoblasts and Endometrial Gland Cells, Regulates the Infiltration of CCR4+ T Lymphocytes into Human Decidua at Early Pregnancy (2002)

Our findings imply that TARC secreted in decidua mediates the infiltration of CCR4+ T-cell migration into the fetomaternal interface, decidua, resulting in the maintenance of pregnancy.
Temporal and Spatial Imaging of Energy Flow at the Nanoscale via Molecular Plasmonics (2012)

Efforts to spatially and temporally resolve photoinduced energy and charge transfer in hybrid plasmonic nanostructures are discussed. Particular emphasis is on coupling between molecular excitonic structures and plasmons. The ability to use these nanostructures to characterize photoinduced energy and charge transfer processes is described.
DEVELOPMENT OF ROADSIDE SAFETY DATA COLLECTION PLAN. FINAL REPORT (1994)

The purpose of this study is to support the roadside aspect of the FHWA High Priority National Research Area on Highway Safety Design Practices and Criteria. The objectives of the study are to: (1) identify issues and gaps in the state of the knowledge needed to improve the cost-effectiveness analysis procedure to be developed under NCHRP Project 22-9, Improved Procedures for Cost-Effectiveness Analysis of Roadside Safety Features, and (2) develop data collection plans for those issues and gaps that can be addressed with accident data. A conceptual framework of the cost-effectiveness model was first formulated. A list of research topics that could potentially improve the cost-effectiveness model was identified. Five proposed research studies were developed from the list: (1) Validation of Encroachment Frequency/Rate, (2) Determination of Encroachment Frequency/Rate Adjustment Factors, (3) Effect of Roadside Conditions on Impact Probability and Severity, (4) Distributions of Impact Conditions, and (5) Relationships of Impact Conditions, Performance Limits, and Injury Probability and Severity. Detailed data collection plans were developed for each of the five proposed studies. A 1-day meeting of an expert panel was convened to critically review these data collection plans. Also, a data collection plan for a combined proposed studies 1 and 2 was developed.
SEMIPARAMETRIC BIVARIATE QUANTILE-QUANTILE REGRESSION FOR ANALYZING SEMI-COMPETING RISKS DATA (2007)

In this paper, we consider estimation of the effect of a randomized treatment on time to disease progression and death, possibly adjusting for high-dimensional baseline prognostic factors. We assume that patients may or may not have a specific type of disease progression prior to death and those who have this endpoint are followed for their survival information. Progression and survival may also be censored due to loss to follow-up or study termination. We posit a semi-parametric bivariate quantile-quantile regression failure time model and show how to construct estimators of the regression parameters. The causal interpretation of the parameters depends on non-identifiable assumptions. We discuss two assumptions: the first applies to situations where it is reasonable to view disease progression as well defined after death and the second applies to situations where such a view is unreasonable. We conduct a simulation study and analyze data from a randomized trial for the treatment of brain cancer.
Acute OSA Impacts Diurnal Alzheimer’s Biomarkers through Nocturnal Hypoxemia and State Transitions (2022)

"Acute OSA Impacts Diurnal Alzheimer's Biomarkers through Nocturnal Hypoxemia and State Transitions." American Journal of Respiratory and Critical Care Medicine, 206(8), pp. 1039–1042
Low CD4+ T Cell Counts among African HIV-1 Infected Subjects with Group B KIR Haplotypes in the Absence of Specific Inhibitory KIR Ligands (2011)

Natural killer (NK) cells are regulated by interactions between polymorphic killer immunoglobulin-like receptors (KIR) and human leukocyte antigens (HLA). Genotypic combinations of KIR3DS1/L1 and HLA Bw4-80I were previously shown to influence HIV-1 disease progression, however other KIR genes have not been well studied. In this study, we analyzed the influence of all activating and inhibitory KIR, in association with the known HLA inhibitory KIR ligands, on markers of disease progression in a West African population of therapy-naïve HIV-1 infected subjects. We observed a significant association between carriage of a group B KIR haplotype and lower CD4+ T cell counts, with an additional effect for KIR3DS1 within the frame of this haplotype. In contrast, we found that individuals carrying genes for the inhibitory KIR ligands HLA-Bw4 as well as HLA-C1 showed significantly higher CD4+ T cell counts. These associations were independent from the viral load and from individual HIV-1 protective HLA alleles. Our data suggest that group B KIR haplotypes and lack of specific inhibitory KIR ligand genes, genotypes considered to favor NK cell activation, are predictive of HIV-1 disease progression.
Development of the Pulmonary Vasculature: Current Understanding and Concepts for the Future (2013)

The pulmonary circulation is a highly specialized vascular bed that physically and functionally connects the heart and the lungs. The interdependence of these two organs is illustrated in embryonic development, when the lung endoderm protrudes into the surrounding mesoderm as the heart tube elongates and folds into structurally distinct chambers. The pulmonary vascular precursors then undergo highly stereotyped cellular maturation and patterning to form a multilayered vascular network that parallels the airways and links the arterial and venous poles of the heart. Upon the first breath, the mature pulmonary circulation is poised to receive the entire cardiac output for efficient gas exchange, and deliver oxygenated blood to the systemic circulation. Disruption of this developmental process can result in congenital defects such as the syndrome tetralogy of Fallot, or differentiation defects leading to persistent pulmonary hypertension of the newborn. Prior studies into the role of angiogenesis and vasculogenesis in pulmonary vascular development have not clearly yielded the identity of pulmonary vascular precursors, or the signals coordinating vascular maturation. We outline key questions on pulmonary vascular development that consider the role of heart-lung interaction in promoting the differentiation and patterning of the pulmonary vasculature.
Agronomic Performance of Hard Red Spring Wheat Isolines Sensitive and Insensitive to Photoperiod (2004)

An increasing number of western Canadian hard red spring wheat cultivars ( Triticum aestivum L.) are photoperiod insensitive, in part, to accommodate short day winter nurseries within breeding programs. The objective of this study was to compare the agronomic performance of near‐isogenic photoperiod sensitive (PS) and insensitive (PI) hard red spring wheat lines over 21 environments (1996–1998) to determine if insensitivity had an effect on agronomic performance. Eight PS and eight PI isogenic lines within each of three genetic backgrounds including AC Minto, CDC Makwa, and SWP5304 were evaluated. The dominant allele Ppd‐D1 conferred insensitivity to PI lines. The experimental design was a randomized complete block design with three replications. Testing environments included Fort Vermillion, AB (58°N), Dawson Creek, BC (55°N), Saskatoon, SK (52°N), Elrose, SK (51°N), Elgin, MB (49°N), Bozeman, MT (45°N), Ste. Foy, QC (46°N), Charlottetown, PE (46°N), Guelph, ON (43°N), and Akron, CO (40°N). Measurements were made on 11 traits including final leaf number, days to heading and maturity, plant height, grain yield, kernel weight, spikelets per spike (total, fertile, and sterile), seeds per spike, and yield per spike. Generally, PS lines were later in heading and maturity, taller, initiated more leaves and spikelet primordia, and 5% higher yielding. Genetic backgrounds differed significantly in all traits, except final leaf number and grain yield. Significant, noncrossover, photoperiod response type × genetic background interactions were observed only for fertile spikelets per spike and seeds per spike. Our results suggest that photoperiod sensitivity may be advantageous in the northern latitudes of North America.
Mass Spectrometry Analysis of the Post-Translational Modifications of α-Enolase from Pancreatic Ductal Adenocarcinoma Cells (2010)

Enolase is a key glycolytic enzyme that catalyzes the dehydration of 2-phosphoglycerate to phosphoenolpyruvate. Recently, enolase was revealed as an important protein in pathophysiological processes since it was found on the surface of hematopoietic cells and overexpressed in several tumor cells. Our previous studies demonstrated that alpha-enolase is up-regulated in pancreatic ductal adenocarcinoma (PDAC). In this present work, we further characterized the alpha-enolase from PDAC and normal pancreatic duct cells by mass spectrometry using LTQ-Orbitrap and identified multiple post-translational modifications of alpha-enolase, such as phosphorylation, acetylation, and methylation. The result showed that more acetylated lysines, methylated aspartic acids, and glutamic acids were found in PDAC cells than that of normal pancreatic duct cells.
An English kindred with a novel recessive tauopathy and respiratory failure (2003)

We present the clinicopathological features of two siblings from a consanguineous marriage who presented with respiratory hypoventilation and died 10 days and 4 years later, respectively. This disorder showed extensive tau neuropathology, and both had a novel homozygous S352L tau gene mutation. This is the first description of a pathologically proved young-onset tauopathy with apparent recessive inheritance.
On tracking performance constrained MFR parameter control (2003)

An efficient Multi Function Radar (MFR) parameter control for single target tracking would minimize the amount of radar resources required for meeting the requirements on tracking performance. In this paper the problem of finding this eficient MFR parameter control is formulated as a constrained minimization problem. No explicit analytical solution to the resulting constrained minimization problem is available (yet). Instead, the resource scheduling and tracking pe rformance results are presented that result from solving it numerically. The two examples for which numerical results are given illustrate the wide range of constraints on tracking performance that can be applied. The insight that can be gained from using this method will in turn be of use in designing, improving, or validating practical algorithms for MFR parameter control.
Design of a 25.5-in Titanium Catenary Riser for the Åsgard B Platform (2000)

Abstract The Åsgard B semi-submersible production platform is located on the Haltenbanken in the North Sea in 305 m water depth. A free hanging 25.5" (ID) titanium riser has been demonstrated to be a robust engineering solution for a large diameter riser from a semisubmersible platform in this water depth. Pre-engineering covering all main aspects was carried out during the spring of 1999. The purpose of the riser is to accommodate the launching of a multi-diameter pig from Åsgard B and to serve as a gas export riser. The riser is presently a backup solution to the base case of subsea pig launching. Presently, there is no other application of a catenary riser in titanium. So far titanium has only been applied to one top tensioned riser, and components, such as stress joints in a limited number of risers. A limited number of free hanging steel risers have been installed in deep water. Isolation joints have been provided at both ends of the titanium riser. In addition to the riser pipe itself the use of titanium is therefore limited to the taper joint in the pontoon support and parts of the isolation joints. Taper joints in titanium as well as the components in steel are considered proven technology. This accommodates the use of proven designs for all components. In spite of not being critical to performance some technical issues are recognised as areas where further technical development is desirable. The most important aspect is considered to be the qualification of welding and NDT procedures. The most highly stressed welds need to meet strict requirements for initial defects. The requirements are determined through fracture mechanics analysis. It is believed that there is a potential for relaxing these criteria by further screening and grouping of available fatigue data in order to reduce uncertainties inherent in the current data. A base case with a uniform 28 mm titanium wall thickness has been developed, with alternatives allowing for a nonuniform wall thickness. The base case gives simpler purchasing logistics, while the advantages of the alternatives are to reduce the required amount of titanium, to simplify production and to reduce the interface forces applied to the platform. A well suited fabrication site which accommodates a straight riser of approximately 700m is located at Aker Verdal in Mid-Norway. Procedures for assembly of the riser, utilizing two weld stations, have been developed. Load out, tow out and installation methods which are insensitive to varying weather conditions have been developed. Surface towing may be applied for the tow out. To limit weather window restrictions provision has also been made for mid water tow out. The installation procedure has initially the riser suspended between two tugs. One end is transferred to the platform whereafter the rear tug moves over onto a different heading to position the riser in the anchor in a cranked configuration. Contingencies for bad weather have been developed for all phases.
Enhancement of Chemical Stability and Crystallinity in Porphyrin‐Containing Covalent Organic Frameworks by Intramolecular Hydrogen Bonds (2013)

Eine starke Bindung: Durch Bildung von intermolekularen Wasserstoffbrücken in kovalenten organischen Gerüsten (COFs) können die Kristallinität, Porosität und chemische Stabilität des Materials verbessert werden (siehe Bild). Das Konzept wird anhand der analogen Methoxyverbindung, die keine Wasserstoffbrücken enthält und entsprechend weniger stabil und kristallin ist, validiert. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod (2007)

Atiprimod is a novel anticancer and antiangiogenic drug candidate which is currently being evaluated in patients with liver carcinoid and multiple myeloma. In this study, we report that atiprimod selectively inhibited proliferation and induced apoptosis in HCC cells that expressed either hepatitis B virus (HBV) or hepatitis C virus, through deactivation of protein kinase B (Akt) and signal transducers and activators of transcription 3 (STAT3) signaling. In HepG2 AD38 cells, which express HBV genome under the control of a tetracycline-off promoter, both Akt and STAT3 were constitutively activated in response to HBV expression. However, this constitutive activation was not sensitive to lamivudine, a drug that inhibits HBV replication without affecting its gene expression, suggesting that HBV replication per se might not be responsible for the activation. Interestingly, the electrophoretic mobility of p-STAT3 protein bands on immunoblot was slower when AD38 cells were cultured in the absence of tetracycline, suggesting a differential phosphorylation in response to HBV expression. In HCC cells, interleukin 6 stimulates the phosphorylation of STAT3 both at serine 727 and at tyrosine 705 positions. The interleukin 6-stimulated activation of STAT3 and Akt was inhibited not only by atiprimod but also by LY294002, a phosphoinositide-3-kinase-specific inhibitor, and by NS398, a cyclooxygenase-2-selective inhibitor. The combination of these compounds did not produce any additive effect, implying that the mechanisms by which HBV activates Akt and STAT3 might also involve phosphoinositide-3-kinase and cyclooxygenase-2. Collectively, these results suggest that atiprimod could be useful as a multifunctional drug candidate for the treatment of HCC in humans.
Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection (2021)

Pre-existing immunity to seasonal endemic coronaviruses could have profound consequences for antibody responses to SARS-CoV-2, induced from natural infection or vaccination. A first step to establish whether pre-existing responses can impact SARS-CoV-2 infection is to understand the nature and extent of cross-reactivity in humans to coronaviruses. Here we compare serum antibody and memory B cell responses to coronavirus spike proteins from pre-pandemic and SARS-CoV-2 convalescent donors using binding and functional assays. We show weak evidence of pre-existing SARS-CoV-2 cross-reactive serum antibodies in pre-pandemic donors. However, we find evidence of pre-existing cross-reactive memory B cells that are activated during SARS-CoV-2 infection. Monoclonal antibodies show varying degrees of cross-reactivity with betacoronaviruses, including SARS-CoV-1 and endemic coronaviruses. We identify one cross-reactive neutralizing antibody specific to the S2 subunit of the S protein. Our results suggest that pre-existing immunity to endemic coronaviruses should be considered in evaluating antibody responses to SARS-CoV-2.
Commissioning of the ATLAS offline software with cosmic rays (2007)

The ATLAS experiment of the LHC is now taking its first data by collecting cosmic ray events. The full reconstruction chain including all sub-systems (inner detector, calorimeters and muon spectrometer) is being commissioned with this kind of data for the first time. Detailed analysis are being performed in order to provide ATLAS with its first alignment and calibration constants and to study the combined muon performance. Combined monitoring tools and event displays have also been developed to ensure good data quality. A simulation of cosmic events according to the different detector and trigger setups has also been provided to verify it gives a good description of the data.
Synthesizing realistic facial expressions from photographs (1998)

Article Free Access Share on Synthesizing realistic facial expressions from photographs Authors: Frédéric Pighin Univ. of Washington, Seattle Univ. of Washington, SeattleView Profile , Jamie Hecker Univ. of Washington, Seattle Univ. of Washington, SeattleView Profile , Dani Lischinski Hebrew Univ. Hebrew Univ.View Profile , Richard Szeliski Microsoft Research Microsoft ResearchView Profile , David H. Salesin Univ. of Washington, Seattle Univ. of Washington, SeattleView Profile Authors Info & Claims SIGGRAPH '98: Proceedings of the 25th annual conference on Computer graphics and interactive techniquesJuly 1998 Pages 75–84https://doi.org/10.1145/280814.280825Published:24 July 1998Publication History 446citation2,172DownloadsMetricsTotal Citations446Total Downloads2,172Last 12 Months71Last 6 weeks7 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Cartilage tissue engineering on fibrous chitosan scaffolds produced by a replica molding technique (2009)

The biocompatibility of chitosan and its similarity with glycosaminoglycans make it attractive as a scaffold for cartilage engineering. Fibrous scaffolds may simulate cartilage extracellular matrix structure and promote chondrocyte functions. Our objectives were to produce chitosan fibers of different size and evaluate their potential for chondrogenesis. A novel replica molding technique was developed to produce chitosan nonwoven scaffolds made of fiber measuring 4, 13, or 22 mum in width. A polyglycolic acid mesh (PGA) served as a reference group. Controls were analyzed 48 h after seeding porcine chondrocytes via scanning electron microscopy (SEM), DNA, and glycosaminoglycan (GAG) quantifications. Constructs were cultured for 21 days prior to confocal microscopy, SEM, histology, and quantitative analysis (weight, water, DNA, GAG and collagen II). Chondrocytes maintained their phenotypic appearance and a viability above 85% on the chitosan scaffolds. Chondrocytes attach preferentially to PGA, resulting in a greater cellularity of these constructs. However, based on the GAG/DNA and Collagen II/DNA ratios, matrix production per chondrocyte was improved in chitosan constructs, especially on smaller fibers. The differences between PGA and chitosan are more likely to result from the chemical composition rather than their structural characteristics. Although chitosan appears to promote matrix formation, further studies should be aimed at improving its cell adhesion properties.