gebhart/patrepeval huggingface dataset:
From modeling to remodeling of upper airways: Centrality of hyaluronan (hyaluronic acid) (2015)

After traumatic events (accidental or surgical), the respiratory tract activates specific and prolix repairing mechanisms which tend to claw back the primitive differentiated state. The attempt of reactivation of the normal tissue functions is called 'remodeling' and its aim is to reinstate the modeling mechanisms that existed before the damaging event or the pathology's establishment. Endoscopic sinus surgery represents the gold standard treatment for inflammatory, malformative, benign, and, in selected cases, malignant diseases. The surgical technique is commonly described as minimally invasive as the nostrils are used as an access route and therefore does not leave any external scars. Currently, the surgical procedures, even though minimally invasive regarding the way in, are in fact widely destructive towards the surgical target. The healing process and re-epithelialization will depend on the amount of bony tissue that has been exposed and it will be important to stratify the different surgical typologies in order to foresee the increasing difficulty of mucosal healing process. As far as upper inflammatory diseases are concerned, recent studies demonstrated how intranasal hyaluronic acid can positively regulate mucosal glands secretion and modulate inflammatory response, being a useful tool for the improvement of remodeling after endoscopic sinus surgery. Acid has shown to be able to regulate mucosal glands secretion and modulate the inflammatory response.
Supplementary Data from Clinical Validation of EndoPredict in Pre-Menopausal Women with ER-Positive, HER2-Negative Primary Breast Cancer (2023)

Supplementary Data from Clinical Validation of EndoPredict in Pre-Menopausal Women with ER-Positive, HER2-Negative Primary Breast Cancer
Scavenger receptor gp340 aggregates group A streptococci by binding pili (2008)

Group A streptococci (GAS) are the most frequent cause of bacterial pharyngitis. The first obstacle to GAS colonization of the pharynx is saliva. As well as forming a physical barrier, saliva contains components of innate and acquired immunity. Previous work has shown that saliva induces bacterial aggregation, which may serve as a clearance mechanism. As the aggregation of some oral streptococci in saliva is mediated by long proteinaceous appendages, we hypothesized that pili of GAS might behave similarly. Wild-type GAS M1 strain SF370 aggregated in saliva, while pilus-defective mutants did not. Similarly, heterologous expression of diverse GAS pili on the surface of Lactococcus lactis induced aggregation in saliva, while control strains were unaffected. Further studies revealed that aggregating bacteria bound salivary component gp340. Purified gp340 aggregated wild-type GAS and L. lactis expressing GAS pili, but not control strains. GAS pilus-defective mutants were abrogated in gp340 binding and aggregation. Furthermore, gp340-mediated aggregation reduced bacterial adhesion to human epithelial cells, suggesting a role in host defence.
Activation of Shiga-like toxins by mouse and human intestinal mucus correlates with virulence of enterohemorrhagic Escherichia coli O91:H21 isolates in orally infected, streptomycin-treated mice (1996)

The enterohemorrhagic Escherichia coli (EHEC) O91:H21 isolates B2F1 and H414-36/89 are virulent in an orally infected streptomycin-treated mouse model. Previous studies demonstrated that B2F1 and H414-36/89 grow to high levels in mucus isolated from mouse small intestine and colon and that growth in small-intestine mucus is related to virulence. We measured the levels of Shiga-like toxins (SLTs) SLT-IIvha and SLT-IIvhb produced by B2F1 after growth in Luria-Bertani (LB) broth supplemented with mouse intestinal mucus by assaying the cytotoxicity of culture supernatants on Vero cells. Culture supernatants from B2F1 grown in mouse intestinal mucus, but not EHEC strains that produce SLT-II or SLT-IIc, were approximately 35- to 350-fold more toxic for Vero cells than supernatants from B2F1 grown in LB broth. This increased toxicity was not reflected by a concomitant increase in SLT antigen content. Furthermore, when culture supernatants from B2F1 or K-12 strains carrying plasmids encoding SLTs cloned from H414-36/89 or purified SLT-IIvhb from B2F1 were incubated with mouse intestinal mucus, the samples exhibited greater cytotoxicity than when they were incubated with N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES) buffer alone. These toxin preparations also showed increased cytotoxicity after incubation with human colonic mucus. In contrast, culture supernatants from LB-grown EHEC isolates that produced SLT-I, SLT-II, SLT-IIc or SLT-IIe did not show increased cytotoxicity after incubation with mouse or human intestinal mucus. The A subunits of purified SLT-II and SLT-IIvhb that had been treated with mouse intestinal mucus or trypsin were cleaved to A1 fragments by the mucus, but trypsin-mediated cleavage, unlike treatment with mouse intestinal mucus, did not result in increased Vero cell cytotoxicity activity. This finding implies that the increased cytotoxicity of SLT-IIvhb detected after incubation with mucus is probably not due to cleavage of the A subunit into the A1 and A2 fragments. Taken together, these results indicate that mouse or human intestinal mucus directly activates SLT-II-related toxins from B2F1 and H414-36/89 and suggest that toxin activation may explain the low 50% lethal doses of B2F1 and H414-36/89 in streptomycin-treated mice.
Systematic Study of the Photoluminescent and Electroluminescent Properties of Pentacoordinate Carboxylate and Chloro Bis(8-hydroxyquinaldine) Complexes of Gallium(III) (1996)

A detailed analysis of the structural, optical absorption, photoluminescent, and electroluminescent properties of a series of pentacoordinate bis(8-hydroxyquinaldine)gallium(III) complexes, i.e. q‘2GaX with X = acetate, dimethylpropionate, benzoate, and chloro, is presented. These materials are compared with tris(8-hydroxyquinaldine)Ga and the tris(8-hydroxyquinolate) complexes of aluminum (Alq3) and gallium. Structural studies show that the pentacoordinate complexes have significantly less steric congestion than their hexacoordinate analogues, leading to comparatively smaller Franck−Condon shifts in their absorption and emission spectra. Relatively short π−π stacking distances are observed between the quinolate or quinaldine ligands of adjacent complexes (i.e., 3.3−3.5 Å), which facilitates electron transport in the materials. All of the pentacoordinate complexes had high electroluminescent efficiencies at low drive currents. The benzoate derivative exhibits light output saturation at high drive currents when used in electroluminescent devices, while the other derivatives had characteristics comparable to that of Alq3 at all drive currents.
A universal self-calibrating Dynamic Voltage and Frequency Scaling (DVFS) scheme with thermal compensation for energy savings in FPGAs (2016)

Field Programmable Gate Arrays (FPGAs) are widely used in telecom, medical, military and cloud computing applications. Unlike in microprocessors, the routing and critical path delay of FPGAs is user dependent. The design tool suggests a maximum operating frequency based on the worst-case timing analysis of the critical paths at a fixed nominal voltage, which usually means there is significant voltage or frequency margin in a typical chip. This paper presents a universal offline self-calibration scheme, which automatically finds the FPGA frequency and core voltage operating limit at different self-imposed temperatures by monitoring design-specific critical paths. These operating points are stored in a calibration table and used to dynamically adjust the frequency and core voltage according to the FPGA temperature when the application circuit is running. The self-calibration process is demonstrated on an Altera Cyclone IV 65-nm FPGA with a digitally controlled dc-dc converter, leading to 40% power savings in a typical digital filter application.
ChemInform Abstract: Selective Oxidation Using Ultrathin Nitrogen‐Rich Silicon Surface Layers Grown by Rapid Thermal Processing. (1989)

Abstract Using the title method, which is described for the first time, well controlled nitrogen‐silicon reactions can achieve a variety of oxidation inhibition effects that can be exploited for fabricating maskless oxide structures for VLSI.
<title>Automotive radar</title> (2004)

Radar networks for automtovie short-range applications (up to 30m) based on powerful but inexpensive 24GHz high range resolution pulse or FMCW radar systems have been developed at the Technical University of Hamburg-Harburg. The described system has been integrated in to an experimental vehicle and tested in real street environment. This paper considers the general network design, the individual pulse or FMCW radar sensors, the network signal processing scheme, the tracking procedure and possible automotive applications, respectively. Object position estimation is accomplished by the very precise range measurement of each individual sensor and additional trilateration procedures. The paper concludes with some results obtained in realistic traffic conditions with multiple target situations using 24 GHz radar network.
Antibodies Directed against Shiga-Toxin Producing Escherichia coli Serotype O103 Type III Secreted Proteins Block Adherence of Heterologous STEC Serotypes to HEp-2 Cells (2015)

Shiga toxin-producing Escherichia coli (STEC) serotype O103 is a zoonotic pathogen that is capable of causing hemorrhagic colitis and hemolytic uremic syndrome (HUS) in humans. The main animal reservoir for STEC is ruminants and hence reducing the levels of this pathogen in cattle could ultimately lower the risk of STEC infection in humans. During the process of infection, STECO103 uses a Type III Secretion System (T3SS) to secrete effector proteins (T3SPs) that result in the formation of attaching and effacing (A/E) lesions. Vaccination of cattle with STEC serotype O157 T3SPs has previously been shown to be effective in reducing shedding of STECO157 in a serotype-specific manner. In this study, we tested the ability of rabbit polyclonal sera against individual STECO103 T3SPs to block adherence of the organism to HEp-2 cells. Our results demonstrate that pooled sera against EspA, EspB, EspF, NleA and Tir significantly lowered the adherence of STECO103 relative to pre-immune sera. Likewise, pooled anti-STECO103 sera were also able to block adherence by STECO157. Vaccination of mice with STECO103 recombinant proteins induced strong IgG antibody responses against EspA, EspB, NleA and Tir but not against EspF. However, the vaccine did not affect fecal shedding of STECO103 compared to the PBS vaccinated group over the duration of the experiment. Cross reactivity studies using sera against STECO103 recombinant proteins revealed a high degree of cross reactivity with STECO26 and STECO111 proteins implying that sera against STECO103 proteins could potentially provide neutralization of attachment to epithelial cells by heterologous STEC serotypes.
Operation of a Gyromagnetic Line with Magnetic Axial Bias (2019)

A growing interest has been raising around the use of nonlinear transmission lines (NLTLs) for radiofrequency (RF) generation since recent results published has demonstrated great prospects for this application. The subject of this paper is about a continuous ferrite loaded nondispersive line known as a gyromagnetic nonlinear transmission line (GNLTL), biased by an axial magnetic field. This type of transmission line has demonstrated a high RF conversion efficiency (up to 20.0%), showing a good capability of operation in a broader frequency range, between 300 MHz and 6.0 GHz. Several authors used different approaches to study the gyromagnetic effect to understand the precession movement of the ferrite magnetic dipoles. The model proposed and studied here to analyze the GNLTL has a coaxial structure using NiZn ferrite beads distributed in a 20-cm coaxial line at a high voltage operation. Signal results were compared to check the influence of a solenoid on the axial magnetic bias. This paper explores the oscillations generated at the output caused by the changes in the magnetic system setup. It is expected that the discussion presented here will be useful as a basis to develop a new system capable of generating RF for mobile defense platforms.
Adhesion and incorporation of lacZ-transduced endothelial cells into the intact capillary wall in the rat. (1992)

Use of the capillary bed of skeletal muscle as an in vivo recipient site to transplant autologous endothelial cells that have undergone gene transfer ex vivo has considerable potential as a technique of somatic gene therapy. Here we document a previously unrecognized capacity of endothelial cells to adhere and incorporate spontaneously into confluent endothelial cell monolayers in vitro and in vivo. This spontaneous adhesion and incorporation of endothelial cells enabled us to seed lacZ-transduced endothelial cells into the wall of skeletal muscle capillaries of the hindlimb of the rat. Certain transduced endothelial cells became incorporated within the capillary wall, whereas others remained within the capillary lumen where they formed focal, electron-dense, contacts with host endothelium. lacZ expression in the capillary bed was documented for up to 1 month after transplantation. Use of the intact capillary bed of skeletal muscle as an in vivo recipient site for transduced, autologous endothelial cells holds promise as a strategy for somatic gene therapy to treat various genetic and acquired human diseases.
POWER SCALING OF VUV AND XUV FREQUENCY COMBS (2010)

Author Institution: JILA, National Institute of Standards and Technology and University of; Colorado, Department of Physics, University of Colorado, Boulder, CO 80309-0440; IMRA America, Inc., 1044 Woodridge Ave., Ann Arbor, MI 48105, USA
Transfer functions interpolating an ideal amplitude with arbitrary phase and delay (1983)

Abstract A method is presented to generate polynomials with phase values and delay (first derivative) specified at given frequencies. Then a closed form solution is described for the scattering transfer function S 12 ( p ) of a resistively terminated lossless reciprocal two‐port network with ideal amplitude and arbitrary phase and delay.
All-solid-state femtosecond diode-pumped Cr:LiSAFlaser (1994)

A femtosecond diode-pumped Cr:LiSAF laser has heen demonstrated for the first time. A multiquantum well absorber has heen used in a dispersion-compensated cavity to yield CW trains of transform-limited femtosecond pulses.
Cancer-Related Epigenome Changes Associated with Reprogramming to Induced Pluripotent Stem Cells (2010)

The ability to induce pluripotent stem cells from committed, somatic human cells provides tremendous potential for regenerative medicine. However, there is a defined neoplastic potential inherent to such reprogramming that must be understood and may provide a model for understanding key events in tumorigenesis. Using genome-wide assays, we identify cancer-related epigenetic abnormalities that arise early during reprogramming and persist in induced pluripotent stem cell (iPS) clones. These include hundreds of abnormal gene silencing events, patterns of aberrant responses to epigenetic-modifying drugs resembling those for cancer cells, and presence in iPS and partially reprogrammed cells of cancer-specific gene promoter DNA methylation alterations. Our findings suggest that by studying the process of induced reprogramming, we may gain significant insight into the origins of epigenetic gene silencing associated with human tumorigenesis, and add to means of assessing iPS for safety.
Image analysis methods for diffuse optical tomography (2006)

Three major analytical tools in imaging science are summarized and demonstrated relative to optical imaging in vivo. Standard resolution testing is optimal when infinite contrast is used and hardware evaluation is the goal. However, deep tissue imaging of absorption or fluorescent contrast agents in vivo often presents a different problem, which requires contrast-detail analysis. This analysis shows that the minimum detectable sizes are in the range of 1/10 the outer diameter, whereas minimum detectable contrast values are in the range of 10 to 20% relative to the continuous background values. This is estimated for objects being in the center of the domain being imaged, and as the heterogeneous region becomes closer to the surface, the lower limit on size and contrast can become arbitrarily low and more dictated by hardware specifications. Finally, if human observer detection of abnormalities in the images is the goal, as is standard in most radiological practice, receiver operating characteristic (ROC) curve and location receiver operating characteristic curve (LROC) are used. Each of these three major areas of image interpretation and analysis are reviewed in the context of medical imaging as well as how they are used to quantify the performance of diffuse optical imaging of tissue.
The Isolation and General Properties of Escherichia coli Malonyl Coenzyme A-Acyl Carrier Protein Transacylase (1973)

Abstract Malonyl coenzyme A-acyl carrier protein transacylase of Escherichia coli was purified 4800-fold by procedures which included chromatography on DEAE-cellulose, Sephadex G-100, Sephadex G-75, DEAE-Sephadex, and preparative polyacrylamide gel electrophoresis. The purified enzyme was shown to be homogeneous by electrophoresis on polyacrylamide gels, by sedimentation equilibrium centrifugation, and by amino acid analysis. A molecular weight of 36,660, obtained with carboxymethylated enzyme by sedimentation equilibrium measurements, agreed with determinations on the native enzyme by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (36,500) and by Sephadex G-100 column chromatography (37,000). An s20,w = 2.31 S was determined for the enzyme by sedimentation velocity measurements. Amino acid analysis and determination of the isoelectric point (pH 4.65) both showed the enzyme to be acidic. The purified enzyme was inhibited by N-ethylmaleimide and to a lesser extent by iodoacetamide, but inhibition by both reagents was significantly increased at pH values above 7.3. Preincubation of the enzyme with malonyl-CoA protected against inactivation by both sulfhydryl reagents. Reduction of aged enzyme preparations by incubation with dithiothreitol was shown to stimulate enzyme activity approximately 5-fold. These experiments suggest that a reduced sulfhydryl group(s) on the enzyme is required for maximal catalytic activity.
Non-holonomic model-based predictive output tracking of an unknown three-dimensional trajectory (2002)

We present a control strategy to track a target trajectory in space with a non-holonomic vehicle. Only noisy, point-wise measurements of the target are available at each time, so that no global optimality can be achieved. Instead, we propose a causal, predictive output-feedback control strategy based upon the recursive approximation of the target with feasible system trajectories.
Improved Multiuser Diversity Using Smart Antennas With Limited Feedback (2005)

Publication in the conference proceedings of EUSIPCO, Antalya, Turkey, 2005
The Beware Home: A Contextually Aware Haunted House (2000)

In the Broadband Institute Residential Laboratory, we are exploring interaction techniques for a contextually aware home [1]. Here we describe several recent projects that were adapted to create a haunted house for demonstration to the International Symposium for Wearable Computers conference during the month of October. These projects included three augmented realities, a location system, and five methods of interacting with the home environment.
Atomic Layer Deposition of V2O5-Carbon Nanotube Cathode With TiO2 Protecting Layer for Lithium Ion Batteries (2013)

Abstract not Available.
ChemInform Abstract: 5‐Aryl‐1,2‐dihydrochromeno[3,4‐f]quinolines: A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Highly Photosensitive Fiber Fabricated from Photo‐Thermo‐Refractive Glass (2014)

With the goal to extend applications of highly photosensitive photo-thermo-refractive (PTR) glass from bulk glass components to the fiber optic platform, we have successfully fabricated single material fibers and step index fibers from PTR type glasses. The fibers were drawn from rod-in-tube preforms which have been prepared using specialty diamond tools for shaping and polishing of the glass materials. We measured attenuations of less than 0.1 dB/cm in our PTR glass fibers. Strong fiber Bragg gratings were inscribed into the novel fibers demonstrating the fibers photosensitivity. High grating strength of up to 20 dB were reached and maintained even at 12 hour exposure to temperatures above 400 °C. Our results open exciting new avenues for the development of holographic PTR glass fiber optic components which may be applied in fiber optic devices that require high temperature stability and high optical power levels.
Low-latency, concurrent checkpointing for parallel programs (1994)

Presents the results of an implementation of several algorithms for checkpointing and restarting parallel programs on shared-memory multiprocessors. The algorithms are compared according to the metrics of overall checkpointing time, overhead imposed by the checkpointer on the target program, and amount of time during which the checkpointer interrupts the target program. The best algorithm measured achieves its efficiency through a variation of copy-on-write, which allows the most time-consuming operations of the checkpoint to be overlapped with the running of the program being checkpointed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Systematic search for pairwise dependencies of torsion angles (2012)

Most available tools for conformer generation, like OMEGA [1], ROTATE [2], and MIMUMBA [3], divide the conformational space into quantized degrees of freedom, i.e. torsion angles, which are treated independently. The independence of torsions is however not valid for all fragments [4]. There are pairs of mutually dependent degrees of freedom e.g. two consecutive torsion angles in aryl-X-aryl systems. The fact that two torsions are dependent implies that if one of the torsions is set to a specific angle, the set of possible angles for the other torsion is limited. This knowledge could be used to significantly narrow down the conformational space in deterministic rule-based conformation generators.

For our systematic search for pairwise dependent torsion angles, we assembled a set of about 200 chemical patterns, each describing a torsion angle and part of its environment. The patterns range from very general descriptions like 'rotatable bond between two sp3 hybridized atoms' to patterns describing a more specific molecular environment.

As a first approach we tried to replicate the examples given by Bramelt et al. using suitable chemical patterns and a CSD [5] subset of about 73,000 molecules as a database. We then performed a pairwise analysis of all our chemical patterns, including each pattern with itself, using again the CSD subset of about 73,000 molecules. We used two different search scenarios. In our first search the torsion angles had to be directly next to each other while in our second search they had to be exactly one bond apart.

Using our systematic search approach we found many additional examples for dependent torsion angles, confirming the findings of Bramelt et al. and supporting their advice to search for pairs of mutually dependent conformation variables.