gebhart/patrepeval huggingface dataset:
High affinity RGD‐binding sites at the plasma membrane ofArabidopsis thalianalinks the cell wall (1998)

The heptapeptide Tyr-Gly-Arg-Gly-Asp-Ser-Pro containing the sequence Arg-Gly-Asp (RGD--the essential structure recognised by animal cells in substrate adhesion molecules) was tested on epidermal cells of onion and cultured cells of Arabidopsis upon plasmolysis. Dramatic changes were observed on both types of cells following treatment: on onion cells, Hechtian strands linking the cell wall to the membrane were lost, while Arabidopsis cells changed from concave to convex plasmolysis. A control heptapeptide Tyr-Gly-Asp-Gly-Arg-Ser-Pro had no effect on the shape of plasmolysed cells. Protoplasts isolated from Arabidopsis cells agglutinate in the presence of ProNectinF, a genetically engineered protein of 72 kDa containing 13 RGD sequences: several protoplasts may adhere to a single molecule of ProNectinF. The addition of the RGD-heptapeptide disrupted the adhesion between the protoplasts. Purified plasma membrane from Arabidopsis cells exhibits specific binding sites for the iodinated RGD-heptapeptide. The binding is saturable, reversible, and two types of high affinity sites (Kd1 approximately 1 nM, and Kd2 approximately 40 nM) can be discerned. Competitive inhibition by several structurally related peptides and proteins noted the specific requirement for the RGD sequence. Thus, the RGD-binding activity of Arabidopsis fulfils the adhesion features of integrins, i.e. peptide specificity, subcellular location, and involvement in plasma membrane-cell wall attachments.
Supplementary Table from Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma (2023)

Supplementary Table from Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma
Angiotensin converting enzyme inhibitors: 1,5-benzothiazepine derivatives (1985)

The synthesis of chiral 1,5-benzothiazepines 2a-c, 14a-c, 15c, and 16a prepared from cysteine is described. In vitro inhibition of angiotensin converting enzyme (ACE) is reported for each compound. Compound 2c was the most potent in vitro having an IC50 of 2.95 nM. The ester of 2c, i.e. 14c, was found to inhibit the AI pressor response by 75% at a dose of 0.05 mg/kg iv and by 39% at 1.0 mg/kg po. Additionally, 14c lowered blood pressure in the spontaneous hypertensive rat (SHR) by 35 mmHg, at a dose of 10 mg/kg po.
X‐Ray Photoelectron Spectroscopy for Characterization of Bionanocomposite Functional Materials for Energy‐Harvesting Technologies (2013)

The analysis of hybrid multicomponent bioorganic and bioinorganic composite materials related to energy technologies by using X-ray photoelectron spectroscopy is discussed. The approaches and considerations of overcoming the difficulties of analyzing hybrid multicomponent materials are demonstrated for different types of materials used in bioenzyme fuel cells, that is, enzyme immobilization in a hybrid inorganic-organic matrix, analysis of peptide binding and structure in the mediation of silica nanoparticle formation, analysis of enzyme-polymeric multilayered architectures obtained through layer-by-layer assembly, and study of the mechanism of electropolymerization. Thorough optimization of experimental design through analysis of an adequate set of reference materials, relevant timescales of sample preparation and X-ray exposure, careful peak decomposition and cross-correlation between elemental speciation, results in a detailed understanding of the chemistry of nanocomposite constituents and interactions between them. The methodology presented and examples discussed are of significant importance to the scientific and engineering communities focused on the immobilization of enzymes, proteins, peptides, and other large biological molecules on solid substrates.
Cilkmem: Algorithms for Analyzing the Memory High-Water Mark of\n Fork-Join Parallel Programs (2019)

Software engineers designing recursive fork-join programs destined to run on\nmassively parallel computing systems must be cognizant of how their program's\nmemory requirements scale in a many-processor execution. Although tools exist\nfor measuring memory usage during one particular execution of a parallel\nprogram, such tools cannot bound the worst-case memory usage over all possible\nparallel executions.\n This paper introduces Cilkmem, a tool that analyzes the execution of a\ndeterministic Cilk program to determine its $p$-processor memory high-water\nmark (MHWM), which is the worst-case memory usage of the program over \\emph{all\npossible} $p$-processor executions. Cilkmem employs two new algorithms for\ncomputing the $p$-processor MHWM. The first algorithm calculates the exact\n$p$-processor MHWM in $O(T_1 \\cdot p)$ time, where $T_1$ is the total work of\nthe program. The second algorithm solves, in $O(T_1)$ time, the approximate\nthreshold problem, which asks, for a given memory threshold $M$, whether the\n$p$-processor MHWM exceeds $M/2$ or whether it is guaranteed to be less than\n$M$. Both algorithms are memory efficient, requiring $O(p \\cdot D)$ and $O(D)$\nspace, respectively, where $D$ is the maximum call-stack depth of the program's\nexecution on a single thread.\n Our empirical studies show that Cilkmem generally exhibits low overheads.\nAcross ten application benchmarks from the Cilkbench suite, the exact algorithm\nincurs a geometric-mean multiplicative overhead of $1.54$ for $p=128$, whereas\nthe approximation-threshold algorithm incurs an overhead of $1.36$ independent\nof $p$. In addition, we use Cilkmem to reveal and diagnose a previously unknown\nissue in a large image-alignment program contributing to unexpectedly high\nmemory usage under parallel executions.\n
Scattering by anisotropic grains in beryllium mirrors (1990)

Scattering from mirror surfaces arises from topographic and non-topographic sources. This paper considers the nontopographic
scattering of beryllium mirrors modelled as a collection of randomly oriented bireflective grains. Simple 
scattering theory shows that this type of scattering scales as r2, rather than as 2 for topographic scattering, which 
means that it is relatively more important at long radiation wavelengths. Estimates of the intensity based an available 
short-wavelength values of the anisotropic optical constants of beryllium indicate that this type of scattering could 
dominate the topographic scattering from smooth surfaces at CO2 wavelengths.
<title>Influence of spectral response dispersion on the performances of infrared imaging systems</title> (1998)

Spectral response dispersion has a significant impact on the radiometric performances of infrared imaging system using detectors with a large amount of pixels. The main contributors of this dispersion are the detector itself, which contributes to the highest spatial dispersion, and the optical components and filters which contribute with smaller frequencies. This paper proposes a theoretical approach of the contribution of spectral response dispersion to the spatial noise, considering classical calibration methods with blackbodies. AEROSPATIALE has performed measurements of spectral response dispersion on large format 2D infrared detectors. The performances obtained taking into account these test results are given in order to identify the real weigh of spectral response dispersion effects on the infrared imaging system.
Impact of Inverter-Interfaced Renewable Energy Generators on Distance Protection and an Improved Scheme (2018)

With different structures and control strategies, inverter-interfaced renewable energy generators (IIREGs) have different fault characteristics from synchronous generators. This makes the conventional distance protection used in networks with synchronous generators not applicable for transmission lines emanating from IIREGs. Therefore, supported by the fault current analysis, operating performances of distance relays on both sides of the transmission line are unveiled. It reveals the problem that the conventional distance relay on the IIREG side has a high risk of malfunction or refusing to operate. To cope with this adaptability problem, an improved scheme based on time delay and zero-sequence impedance is proposed in this paper. To validate the operating performances of the scheme, a detailed IIREG model is built in a real-time digital simulator, and simulation tests are carried out. Apart from these, a field short-circuit test is performed in a real wind power plant to examine the practical feasibility of the proposed scheme. Both the simulation results and the field test confirm the problem of the conventional distance protection and verify the reliability of the improved scheme.
Stromal effects of PDGFR inhibition by STI571 in experimental carcinoma: Altered collagen fibrils and reduction of a specific stromal cell population (2010)

In addition to malignant cells, solid tumors comprise supporting stromal tissue that consists of extra cellular matrix (ECM), connective tissue cells, inflammatory cells and blood vessels. The stromal compartment and the malignant cells together shape the tumor microenvironment that in turn determines tumor progression and efficacy of anti-tumor treatments. In this thesis, studies that investigate the roles of different kinds of interactions between tumor cells and stromal cells were undertaken. Further, growth factors that have important roles in interactions between tumor cells and stromal cells were investigated in a non-tumor environment. Tumor cells were found to modulate the response to the platelet derived growth factor (PDGF) by microvascular pericytes, a cell type found in the vasculature of solid tumors. The importance of this growth factor in biology of tumors has earlier been shown, but here it was shown that PDGF also modulate the ECM phenotype of solid tumors. The ECM of tumors treated with an inhibitor of PDGF receptor (PDGFR) signaling induced a less fibrotic collagen scaffold, which could explain how PDGFR inhibition in earlier reports lowered tumor interstitial fluid pressure (IFP). Lowering the normally high IFP in tumors increases efficacy of chemotherapy. The integrin αVβ3 is activated downstream of PDGF-B in acute inflammations, and this integrin is important for raising IFP in loose connective tissue in such conditions. However, in tumors we found that lack of the β3 subunit lead to an increased IFP, which were attributed to a more fibrotic ECM phenotype. In addition to PDGF-B, transforming growth factor β (TGFβ) is an important growth factor in the biology of tumors. These two growth factors were separately overexpressed in mouse skin and they both induced an inflammatory response. Expressed in a tumor free context, they evoked a response that was in many ways reminiscent of what can be observed in the tumor microenvironment. This thesis contributes further understanding of how the complex tumor microenvironment affects the phenotype of solid tumors.
On the [ir]relevance of network performance for data processing (2016)

Modern data processing frameworks are used in a variety of settings for a diverse set of workloads such as sorting, indexing, iterative computations, structured query processing, etc. As these frameworks run in a distributed environment, a natural question to ask is – how important is the network to the performance of these frameworks? Recent research in this field has led to contradictory results. One camp advocates the limited impact of networking performance on the overall performance of the framework [16]. On the other hand, there is a large body of work on networking optimizations for data processing frameworks [9, 10, 18, 19, 21]. In this paper, we search for a better understanding of the matter. While answering the basic question concerning the importance of the network performance, our analysis raises new questions and points to previously unexplored or unnoticed avenues for performance optimizations. We take Apache Spark [2] as a representative of a modern data-processing framework. However, to broaden the scope of our investigation, we also experiment with other frameworks such as Flink, PowerGraph or Timely. In our study – rather than analysing Spark-specific peculiarities – we look into procedures and subsystems that are common in any of these frameworks such as networking IO, shuffle data management, object (de)serialization, copies, job scheduling and coordination, etc. Nonetheless, we are aware that the roles of those individual components are different for the various systems, and we exercise caution when making generalized statements about the performance. Our study reveals three main findings: (a) up to a certain level, the performance of the network has significant effects on the overall performance of the data processing framework. Specifically, for all the workloads and frameworks we analyzed, moving from a 1 to a 10 Gbps network reduced the query response time by a factor of two and more (see Figure 1). This result directly 0 50 100 150 200 250
Synthesis of Red-Shifted 8-Hydroxyquinoline Derivatives Using Click Chemistry and Their Incorporation into Phosphorylation Chemosensors (2009)

Protein phosphorylation is a ubiquitous post-translational modification, and protein kinases, the enzymes that catalyze the phosphoryl transfer, are involved in nearly every aspect of normal, as well as aberrant, cell function. Here we describe the synthesis of novel, red-shifted 8-hydroxyquinoline-based fluorophores and their incorporation into peptidyl kinase activity reporters. Replacement of the sulfonamide group of the sulfonamido-oxine (&lt;b&gt;1&lt;/b&gt;, Sox) chromophore, which has been previously used in kinase sensing, by a 1,4-substituted triazole moiety prepared via click chemistry resulted in a significant bathochromic shift in the fluorescence excitation (15 nm) and emission (40 nm) maxima for the Mg&lt;sup&gt;2+&lt;/sup&gt; chelate. Furthermore, when a click derivative was incorporated into a chemosensor for MK2, the kinase accepted the new substrate as efficiently as the previously reported Sox-based sensor. Taken together, these results extend the utility range of kinase sensors that are based on chelation-enhanced fluorescence (CHEF).
Rigorous Science: a How-To Guide (2016)

ABSTRACT Proposals to improve the reproducibility of biomedical research have emphasized scientific rigor. Although the word “rigor” is widely used, there has been little specific discussion as to what it means and how it can be achieved. We suggest that scientific rigor combines elements of mathematics, logic, philosophy, and ethics. We propose a framework for rigor that includes redundant experimental design, sound statistical analysis, recognition of error, avoidance of logical fallacies, and intellectual honesty. These elements lead to five actionable recommendations for research education.
A Rice-Based Oral Cholera Vaccine Induces Macaque-Specific Systemic Neutralizing Antibodies but Does Not Influence Pre-Existing Intestinal Immunity (2009)

We previously showed that oral immunization of mice with a rice-based vaccine expressing cholera toxin (CT) B subunit (MucoRice-CT-B) induced CT-specific immune responses with toxin-neutralizing activity in both systemic and mucosal compartments. In this study, we examined whether the vaccine can induce CT-specific Ab responses in nonhuman primates. Orally administered MucoRice-CT-B induced high levels of CT-neutralizing serum IgG Abs in the three cynomolgus macaques we immunized. Although the Ab level gradually decreased, detectable levels were maintained for at least 6 mo, and high titers were rapidly recovered after an oral booster dose of the rice-based vaccine. In contrast, no serum IgE Abs against rice storage protein were induced even after multiple immunizations. Additionally, before immunization the macaques harbored intestinal secretory IgA (SIgA) Abs that reacted with both CT and homologous heat-labile enterotoxin produced by enterotoxigenic Escherichia coli and had toxin-neutralizing activity. The SIgA Abs were present in macaques 1 mo to 29 years old, and the level was not enhanced after oral vaccination with MucoRice-CT-B or after subsequent oral administration of the native form of CT. These results show that oral MucoRice-CT-B can effectively induce CT-specific, neutralizing, serum IgG Ab responses even in the presence of pre-existing CT- and heat-labile enterotoxin-reactive intestinal SIgA Abs in nonhuman primates.
(Invited) John B. Goodenough's Centenarian : Success Story of LiFePO4 (LFP) As Cathode Material for Rechargeable Lithium Batteries (2022)

Lithium-ion and solid-state battery (SSB) are now playing a central role in consumer electronic, energy storage and electric vehicles thanks to their excellent cycle life and high energy density. One of the key components that have paved the way for this success story in the past 27 years is LiFePO 4 (LFP) which has served as a lithium-ion host structure for the cathode electrode. Today only LFP is used in both commercial Li-ion and SSB batteries, due their safety, low cost (cobalt free), fast charge and discharge, and over 20 years of calendar life. In this presentation, we will show the progress of the physical chemistry of the olivine compounds since the pioneering work of Prof. John B. Goodenough. This major improvement has positioned LiFePO 4 as the active cathode element of a new generation of Li-ion batteries from cell to pack, hence making a breakthrough in the technology of energy storage and electric transportation. This achievement is the fruit of about 27 years of intensive research in the electrochemical community during which chemists, electrochemists, physicists, and engineers added their efforts to understand the properties of the material, to overcome the obstacles that were met on the way, and finally to reach the state of the art enabling its ubiquitous use in technology today and in the future.
One-stage hip reconstruction in children with cerebral palsy: Long-term results at skeletal maturity (2014)

retrospective study.
Mode-division Multiplexed Transmission with Fiber Mode Couplers (2012)

We describe the mode-division multiplexing(MDM) transmission using a conventional fiber coupler with negligible modal crosstalk. A 2×10Gbps MDM transmission was achieved over a 10km two-mode fiber without any signal processing.
Immobilization and heterodimerisation of helix-loop-helix polypeptides on gold surfaces - a model system for peptide-surface interactions (2003)

Immobilization and heterodimerisation of helix-loop-helix polypeptides on gold surfaces - a model system for peptide-surface interactions
Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-β Production (2015)

Plasmacytoid dendritic cells (pDCs) efficiently produce large amounts of type I IFN in response to TLR7 and TLR9 ligands, whereas conventional DCs (cDCs) predominantly secrete high levels of the cytokines IL-10 and IL-12. The molecular basis underlying this distinct phenotype is not well understood. In this study, we identified the MAPK phosphatase Dusp9/MKP-4 by transcriptome analysis as selectively expressed in pDCs, but not cDCs. We confirmed the constitutive expression of Dusp9 at the protein level in pDCs generated in vitro by culture with Flt3 ligand and ex vivo in sorted splenic pDCs. Dusp9 expression was low in B220(-) bone marrow precursors and was upregulated during pDC differentiation, concomitant with established pDC markers. Higher expression of Dusp9 in pDCs correlated with impaired phosphorylation of the MAPK ERK1/2 upon TLR9 stimulation. Notably, Dusp9 was not expressed at detectable levels in human pDCs, although these displayed similarly impaired activation of ERK1/2 MAPK compared with cDCs. Enforced retroviral expression of Dusp9 in mouse GM-CSF-induced cDCs increased the expression of TLR9-induced IL-12p40 and IFN-β, but not of IL-10. Conditional deletion of Dusp9 in pDCs was effectively achieved in Dusp9(flox/flox); CD11c-Cre mice at the mRNA and protein levels. However, the lack of Dusp9 in pDC did not restore ERK1/2 activation after TLR9 stimulation and only weakly affected IFN-β and IL-12p40 production. Taken together, our results suggest that expression of Dusp9 is sufficient to impair ERK1/2 activation and enhance IFN-β expression. However, despite selective expression in pDCs, Dusp9 is not essential for high-level IFN-β production by these cells.
Detection Performance of Transmitter Identification for ATSC 3.0 (2018)

In the ATSC 3.0 physical layer standard, a Transmitter Identification (TxID) technology is introduced in order to identify and distinguish each transmitter in single frequency network (SFN) environment. In SFN, it is essential to accurately measure the strength and delay of broadcast signal from each transmitter, and therefore, the network configuration can be appropriately designed and managed by adj usting transmitting power and emission time of each transmitter. In ATSC 3.0, the TxID technology based on RF watermark provides an efficient way to identify each transmitter without turning it on and off. This paper presents TxID detection performance through computer simulation and laboratory test.
Digital Micromirror Device™: Commercialization of a Massively Parallel MEMS Technology (1997)

Abstract The Digital Micromirror Device™ (DMD™) is an optical, massively parallel microelectromechanical systems (MEMS) technology that has 500,000 to 1,300,000 rotating digital micromirrors monolithically formed over a CMOS address circuit. Each micromirror acts as a digital light switch. The DMD is the only MEMS light modulator technology to be commercialized in a projection display application. Because the DMD is digital and has numerous moving parts, the commercialization process has had its unique challenges and rewards. This paper introduces DMD technology and presents its R&amp;D history and current focus. The quality, reliability, and manufacturing challenges of this important new display technology also are presented, along with the factors that led to the successful resolution of these challenges.
Biochemical and Biological Studies on Dopastin, an Inhibitor of Dopamineβ-Hydroxylase (1974)

Dopastin produced by a pseudomonas is a potent inhibitor of dopamine β-hydroxylase. Kinetic studies with the purified enzyme indicated that inhibition by dopastin was of the uncompetitive type to the substrate and of the competitive to the cofactor, ascorbic acid. The nitrosohydroxylamino group of dopastin was found to be essential in inhibition of dopamine β-hydroxylase. Both racemic and natural dopastins showed the same activity. Dopastin showed significant hypotensive effect to spontaneously hypertensive rats and phytotoxicity to barley germination.
Mapping misorientation and crystallographic tilt in GaN layers via polychromatic microdiffraction (2006)

Abstract The spatial distribution of strain, dislocations, and crystallographic orientation in uncoalesced and coalesced GaN layers grown on striped Si or SiC substrates was studied by polychromatic X‐ray microdiffraction and high resolution monochromatic X‐ray diffraction. Tilt boundaries formed at the column/wing interface depending on the growth conditions and geometry of the striped substrate. The measurements revealed that the free‐hanging wings are tilted upward at room temperature. A misorientation between the GaN(0001) and the Si(111) or SiC(0001) surface normal is observed. Distinct structural properties of the pendeo and cantilever epitaxially grown samples are discussed. (© 2006 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Milton Brown and the founding of western swing (1995)

milton brown and the founding of western swing is available in our book collection an online access to it is set as public so you can get it instantly. Our digital library hosts in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Merely said, the milton brown and the founding of western swing is universally compatible with any devices to read.