gebhart/patrepeval huggingface dataset:
Optical Characterization of Double Peak Behavior in 1011 Semipolar Light-Emitting Diodes on Miscutm-Plane Sapphire Substrates (2012)

{101} semipolar GaN-based light-emitting diodes (LEDs) grown on 1° miscut m-plane sapphires substrates via metal organic chemical vapor deposition showed undulated surface morphology with ridges and valleys. On the ridge regions, two dominant emission peaks, one at a shorter wavelength (∼438 nm) and one at a longer wavelength (∼490 nm), were observed using electroluminescence and micro-photoluminescence. In the valley regions, the longer peak was observed to be significantly quenched due to the grain boundary. The origin of the longer peak is believed to be not only inhomogeneous distribution of In composition in multiple quantum wells (MQWs) but also strong localization around the ridge region. Moreover, thickness variation of faceted MQWs could be associated with the peak broadening in 101 semipolar LEDs. The results were also confirmed by cathodoluminescence and cross-sectional transmission electron microscopy.
Suicide After Breast Cancer: an International Population-Based Study of 723 810 Women (2006)

Few studies have examined long-term suicide risk among breast cancer survivors, and there are no data for women in the United States. We quantified suicide risk through 2002 among 723,810 1-year breast cancer survivors diagnosed between January 1, 1953, and December 31, 2001, and reported to 16 population-based cancer registries in the United States and Scandinavia. Among breast cancer survivors, we calculated standardized mortality ratios (SMRs) and excess absolute risks (EARs) compared with the general population, and the probability of suicide. We used Poisson regression likelihood ratio tests to assess heterogeneity in SMRs; all statistical tests were two-sided, with a .05 cutoff for statistical significance. In total 836 breast cancer patients committed suicide (SMR = 1.37, 95% confidence interval [CI] = 1.28 to 1.47; EAR = 4.1 per 100,000 person-years). Although SMRs ranged from 1.25 to 1.53 among registries, with 245 deaths among the sample of US women (SMR = 1.49, 95% CI = 1.32 to 1.70), differences among registries were not statistically significant (P for heterogeneity = .19). Risk was elevated throughout follow-up, including for 25 or more years after diagnosis (SMR = 1.35, 95% CI = 0.82 to 2.12), and was highest among black women (SMR = 2.88, 95% CI = 1.44 to 5.17) (P for heterogeneity = .06). Risk increased with increasing stage of breast cancer (P for heterogeneity = .08) and remained elevated among women diagnosed between 1990 and 2001 (SMR = 1.36, 95% CI = 1.18 to 1.57). The cumulative probability of suicide was 0.20% 30 years after breast cancer diagnosis.
Nickel Supported on Mesoporous Alumina for Dry Reforming of Methane: Combustion Method (2017)

Ni catalysts supported on ordered mesoporous alumina (OMA) were prepared by EISA method and calcined under air and Ar atmospheres. Both catalysts showed stable performance for the dry reforming of methane for 24 h, however the catalytic activity of Ar calcined catalyst was relatively lower than that in the air calcined one. It was found that the carbon (C β ) layer around nickel particles was observed for the Ar calcined catalyst after dry reforming of methane. The encapsulating carbon species in the Ar calcined catalyst lowering the mass transfer rate of feeds led to lower performance, but no whisker carbon was observed. In the case of the air calcined catalyst, whisker carbon (C(v)) which is inactive during dry reforming was accumulated on the catalyst, and it resulted in catalyst breakdown and pressure drop during the reaction.
T1ρ Dispersion in Articular Cartilage (2015)

T1ρ/T2 ratio, a new tool, and cartilage initial elastic modulus are both measures of water-protein interactions, are dependent on the cartilage structure, and were correlated in this study.
New generation of hemoglobin-based oxygen carriers evaluated for oxygenation of critically ischemic hamster flap tissue (2005)

Our study suggests that in critically ischemic and hypoxic collateralized peripheral tissue, oxygenation may be improved by normovolemic hemodilution with HbV-HES. We attributed this improvement to a better restoration of the microcirculation and oxygen delivery due to the formulation of the solution.
CM93, a novel covalent small molecule inhibitor targeting lung cancer with mutant EGFR (2020)

Abstract Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have provided successful targeted therapies for patients with EGFR-mutant non-small-cell lung cancer (NSCLC). Osimertinib (AZD9291) is a third-generation irreversible EGFR TKI that has received regulatory approval for overcoming resistance mediated by the EGFR T790M mutation as well as a first-line treatment targeting EGFR activating mutations. However, a significant fraction of patients cannot tolerate the adverse effect associated with AZD9291. In addition, brain metastases are common in patients with NSCLN and remain a major clinical challenge. Here, we report the development of a novel third-generation EGFR TKI, CM93. Compared to AZD9291, CM93 exhibits improved lung cancer targeting and brain penetration and has demonstrated promising antitumor efficacy in mouse models of both EGFR-mutant NSCLC orthotopic and brain metastases. In addition, we find that CM93 confers superior safety benefits in mice. Our results demonstrate that further evaluations of CM93 in clinical studies for patients with EGFR-mutant NSCLC and brain metastases are warranted.
Iodine‐Induced Cyclizations of N‐Alkoxyaminoalkenes. A Stereocontrolled Approach to trans‐2,6‐Disubstituted Piperidine Alkaloids. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
ChemInform Abstract: Phenylcyclohexene and Phenylcyclohexadiene Substituted Compounds Having Retinoid Antagonist Activity. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
[Establishment of novel biomarkers for Personalized medication for atopic dermatitis]. (2013)

To diagnose atopic dermatitis (AD), an appearance of eczema examined by experienced dermatologists is required. Therefore, biomarkers to diagnose AD or to reflect the severity of AD would be of a great use for non-specialists in the clinic or hospitals. We can apply such a biomarker for realization of personalized medicine for AD in the future. Interleukin-4 (IL-4) and IL-13 have been known to play important roles in the pathogenesis of allergic diseases including AD. In addition to these, we previously identified SCCA1, SCCA2, and periostin as IL-4/IL-13-inducible genes. We recently established ELISA systems to measure serum levels of SCCA1, SCCA2, and periostin and evaluated their usefulness in the treatment of AD patients. Serum SCCA1 and SCCA2 are up-regulated in AD patients and can distinguish AD patients from non-atopic controls, and their serum levels reflect eczema grades. Periostin concentration is also elevated in the serum of AD patients. These results demonstrate that SCCA1, SCCA2, and periostin might be promising biomarkers for personalized medicine in allergic diseases including AD.
Automatic detection of tertiary lymphoid structures in whole-slide images of triple-negative breast cancer biopsies (Conference Presentation) (2023)

Triple-negative breast cancer (TNBC) is defined by a lack of biomarkers in the tumor. This inherent lack of targets results in a lack of effective therapeutic tools. However, immunotherapies have shown promise in treating TNBC. Here, we present computer vision methods for automatic detection of immune cells and larger immune structures in TNBC. We demonstrate accurate cell detection and segmentation in highly-multiplexed, whole-slide images of TNBC biopsies. Additionally, we show preliminary spatial analyses that identify and characterize tertiary lymphoid structures within the tumor. Ultimately, we hope to implement these methods to predict responders and non-responders to immunotherapy regimens for TNBC.
Identification of a genetic signature enriching for response to ibrutinib in relapsed/refractory follicular lymphoma in the DAWN phase 2 trial (2021)

NCT01779791.
Biocompatibility of atomic layer deposited alumina thin films (2007)

Abstract: Presented in this paper is a study of the biocom-patibility of an atomic layer-deposited (ALD) alumina (Al2O3) thin film and an ALD hydrophobic coating on stand-ard glass cover slips. The pure ALD alumina coating exhib-ited a water contact angle of 558 6 58 attributed, in part, to a high concentration of OH groups on the surface. In con-trast, the hydrophobic coating (tridecafluoro-1,1,2,2-tetrahy-dro-octyl-methyl-bis(dimethylamino)silane) had a water con-tact angle of 1088 6 28. Observations using differential inter-ference contrast microscopy on human coronary artery smooth muscle cells showed normal cell proliferation on both the ALD alumina and hydrophobic coatings when compared to cells grown on control substrates. These observations sug-gested good biocompatibility over a period of 7 days in vitro. Using a colorimetric assay technique to assess cell viability,
Metasequoia glyptostroboides potentiates anticancer effect against cervical cancer via intrinsic apoptosis pathway (2021)

This study was undertaken to investigate the anticancer effects of organic extracts derived from the floral cones of Metasequoia glyptostroboides. Dried powder of M. glyptostroboides floral cones was subjected to methanol extraction, and the resulting extract was further partitioned by liquid-liquid extraction using the organic solvents n-hexane, dichloromethane (DME), chloroform, and ethyl acetate in addition to deionized water. HeLa cervical and COS-7 cells were used as a cancer cell model and normal cell control, respectively. The anticancer effect was evaluated by using the Cell Counting Kit-8 assay. The viability of COS-7 cells was found to be 12-fold higher than that of the HeLa cells under the administration of 50 µg/ml of the DME extract. Further, the sub-G1 population was determined by FACS analysis. The number of cells at the sub-G1 phase, which indicates apoptotic cells, was increased approximately fourfold upon treatment with the DME and CE extracts compared with that in the negative control. Furthermore, RT-qPCR and western blotting were used to quantitate the relative RNA and protein levels of the cell death pathway components, respectively. Our results suggest that the extracts of M. glyptostroboides floral cones, especially the DME extract, which possesses several anticancer components, as determined by GC-MS analysis, could a potential natural anticancer agent.
Modification of the Internal Flows of Thermal Propulsion Systems Using Local Aerodynamic Inserts (2020)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Modern thermal propulsion systems (TPS) as part of hybrid powertrains are becoming increasingly complex. They have an increased number of components in comparison to traditionally powered vehicles leading to increased demand in packaging requirements. Many of the components in these systems relate to achieving efficiency gains, weight saving and pollutant reduction. This includes turbochargers and diesel or gasoline particulate filters for example and these are known to be very sensitive to inlet boundary conditions. When overcoming packaging requirements, sub-optimal flow distributions throughout the TPS can easily occur. Moreover, the individual components are often designed in isolation assuming relatively flat and artificially quiescent inlet flow conditions in comparison to those they are actually presented with. Thus, some of the efficiency benefits are lost through reduced component aerodynamic efficiency. Using local aerodynamic modification devices, StreamVane&lt;sup&gt;TM&lt;/sup&gt;, to eliminate excessive secondary velocity components prior to TPS component inlet boundaries is considered one solution to this. This type of device has been previously demonstrated to be effective at generating a wide range of secondary velocity profiles. With minor modifications, it should be possible to use these devices to instead remove secondary velocities. As a demonstration, a vane-pack designed to generate a counter-rotating vortex pair in a duct from a uniform flow is considered. An investigation is then carried out using Reynolds-Averaged Navier-Stokes (RANS) numerical simulation to assess the effectiveness of the same device in removing vorticity and secondary velocity components when presented with its design outflow in reverse, i.e. producing uniform flow when presented with a complex inlet flow. Results presented demonstrate clear potential for a vane pack to be used to produce a uniform flow thereby addressing the TPS packaging problem. Without any design modification for reverse flow, the insert reduced the mean secondary velocity magnitude by around 75% without a notable increase in system pressure loss. Consequently, proof-of-concept has been achieved and the use of a generic vane pack design process provides a realistic solution worthy of further development&lt;/div&gt;&lt;/div&gt;
Reduced Graphene Oxide Aerogels with Functionalization-Mediated Disordered Stacking for Sodium-Ion Batteries (2022)

Surface modified reduced graphene oxide (rGO) aerogels were synthesized using the hydrothermal method. Ethylene diamine (EDA) and α-cyclodextrin (CD) were used to functionalize the surface of the graphene oxide layers. The oxygen reduction and surface modification occurred in-situ during the hydrothermal self-assembly process. The chemical functionality and structure of the resulting ethylene diamine modified (rGO-EDA) and cyclodextrin modified (rGO-CD) aerogels as well as of the pristine unmodified rGO aerogel were studied using XPS, SEM, XRD, and SANS techniques. The overall surface composition showed a significant decrease in the oxygen content for all synthesized aerogels. The surface modified aerogels were characterized by a disordered stacking of the assembled rGO layers. The surface functionalities resulted in a broad distribution of the interlayer spacing and introduced structural heterogeneities. Such disordered structures can enable a better adsorption mechanism of the sodium ions. Coin cells based on the synthesized aerogels and sodium metal were assembled and tested at several charge and discharge rates. The correlation between the surface functionality of the rGO, the induced structural heterogeneities due to the disordered stacking, and the electrochemical performance of sodium-ion batteries were investigated. Operando XRD measurements were carried out during the battery cycling to investigate the adsorption or intercalation nature of the sodiation mechanism.
Structure-induced asymmetry between counterpropagating modes in three-port couplers (2018)

The continuing controversy regarding the validity of assuming different photon lifetimes for counterpropagating modes in whistle-geometry ring resonators has led us to re-examine the commonly held view that coupling coefficients between any two ports in Y-junction couplers (regardless of their symmetry) do not depend on the direction of propagation. Rigorous three-dimensional finite-difference time-domain simulations show that the common assumptions about the operation o three-port couplers are sometimes grossly incorrect, as they arise from an oversimplified analytical model. An explanation is given why our results do not violate the Helmholtz reciprocity principle.
Comparative In Vitro Activity Profiles of Novel Bis-Indole Antibacterials against Gram-Positive and Gram-Negative Clinical Isolates (2010)

ABSTRACT Antimicrobial susceptibilities of 233 Gram-positive and 180 Gram-negative strains to two novel bis-indoles were evaluated. Both compounds were potent inhibitors of Gram-positive bacteria, with MIC 90 values of 0.004 to 0.5 μg/ml. One bis-indole, MBX 1162, exhibited potent activity against all Gram-negative strains, with MIC 90 values of 0.12 to 4 μg/ml, even against high-level-resistant pathogens, and compared favorably to all comparator antibiotics. The bis-indole compounds show promise for the treatment of multidrug-resistant clinical pathogens.
The dawn of blue-phase liquid crystal displays (2011)

A hysteresis-free blue-phase LCD with low operation voltage, high contrast ratio, and submillisecond response time is demonstrated using a vertical field switching cell. Some remaining challenges, such as wider blue-phase temperature range, lower operation voltage, and higher voltage holding ratio remain to be overcome before widespread applications can be realized.
Supplemental Figure 4 from Multiparametric MR-PET Imaging Predicts Pharmacokinetics and Clinical Response to GDC-0084 in Patients with Recurrent High-Grade Glioma (2023)

&lt;p&gt;Correlation between Cmax and AUC.&lt;/p&gt;
Application of hydrogenated palm kernel oil and palm stearin in whipping cream (1993)

Abstract Non‐dairy creams made from hydrogenated palm kernel oil (HPKO) are generally more stable than dairy creams. However, in summer the emulsion tends to separate. This paper outlines some steps that were taken to modify the HPKO with the intention of increasing the stability without affecting whipping performance. This was achieved by blending HPKO with palm stearin (POs). Interesterification was employed to eliminate the increase in solid fat content at 37°C and 40°C. Results of the experiment showed that an interesterified HPKO: POs 66:34 blend proved to have satisfactory whipping performance when compared to creams made with HPKO alone.
Séquences chaotiques pour les systèmes CDMA (2005)

Nous nous sommes interesses dans cette these au probleme general de l'optimisation des performances d'un systeme de communication numerique, acces multiple par repartition des codes (CDMA) par un choix ou encore une synthese des sequences d'etalement. Apres avoir decrit brievement les approches classiques, basees essentiellement des constructions dans le corps des symboles binaires ainsi qu'une optimisation des parametres de correlation maximaux associes, nous nous sommes concentres sur des approches plus recentes, basees sur une minimisation des statistiques d'ordre 2 de l'interference inter- utilisateurs. Notre travail s'est alors naturellement articule en trois grandes parties. Dans la premiere partie nous avons decrit les sequences d'etalement optimales pour le systeme lorsqu’un recepteur conventionnel est considere. Nous avons propose une implementation de ces sequences par le biais de sequences chaotiques Markoviennes lineaires par parties. Dans la deuxieme partie de cette these, nous avons considere les performances de ces sequences pour des systemes CDMA en lien asynchrone et munis de detecteurs multi- utilisateurs lineaires. Nous avons alors montre, que les sequences (10,2)-Markoviennes retenues dans la premiere partie du travail amelioraient nettement les performances du systeme. Dans la derniere partie de notre these nous avons discute l'emploi des sequences d'etalement chaotiques (10,2)-Markoviennes dans un contexte de systemes CDMA asynchrones multicodes. Nous avons alors montre que les performances des sequences (10,2)-Markoviennes sont alors clairement superieures a celle des solutions classiques adoptees pour les systemes multicodes.
Inhibition of AKR leukemogenesis by SMX-1, a dualtropic murine leukemia virus. (1980)

Intrathymic injection of SMX-1, a dualtropic murine leukemia virus (MuLV) originally derived from Moloney murine leukemia virus stocks, protects AKR mice from developing MuLV-accelerated leukemia and spontaneous leukemia. Thymuses of SMX-1-injected mice show no change in weight, morphology, or thymocyte size, and quantitative expression of Thy-1 and Lyt-2 differentiation antigens is identical to control mice. The amplified thymic expression of MuLV-related antigens that occurs spontaneously in 6-month-old preleukemic AKR mice or that can be induced in young AKR mice by leukemogenic AKR dualtropic MuLV is prevented by SMX-1. It appears unlikely that the protective effect of SMX-1 is explicable in terms of cross-immunogenicity with transforming MuLV or transformed cells. As SMX-1 persists for long periods after intrathymic injection and does not alter levels of thymic ecotropic MuLV, SMX-1 may interfere with the generation, spread, or leukemogenicity of dualtropic MuLV that form de novo in AKR thymus during the late preleukemic phase. SMX-1 provides a way to probe the events leading to cell transformation in AKR mice.
Preconditioning reduces tissue complement gene expression in the rabbit isolated heart (1999)

Both preconditioning and inhibition of complement activation have been shown to ameliorate myocardial ischemia-reperfusion injury. The recent demonstration that myocardial tissue expresses complement components led us to investigate whether preconditioning affects complement expression in the isolated heart. Hearts from New Zealand White rabbits were exposed to either two rounds of 5 min global ischemia followed by 10 min reperfusion (ischemic preconditioning) or 10 microM of the ATP-dependent K+ (KATP) channel opener pinacidil for 30 min (chemical preconditioning) before induction of 30 min global ischemia followed by 60 min of reperfusion. Both ischemic and chemical preconditioning significantly (P < 0.05) reduced myocardial C1q, C1r, C3, C8, and C9 mRNA levels. Western blot and immunohistochemistry demonstrated a similar reduction in C3 and membrane attack complex protein expression. The K(ATP) channel blocker glyburide (10 microM) reversed the depression of C1q, C1r, C3, C8, and C9 mRNA expression observed in the pinacidil-treated hearts. The results suggest that reduction of local tissue complement production may be one means by which preconditioning protects the ischemic myocardium.
Safety and efficacy of long-term low-dose clozapine aftercare treatment in a patient with learning difficulties who suffered from neuroleptic malignant syndrome (2002)

Large-scale studies are needed to substantiate this observation. (Int J Psych Clin Pract 2002; 6: 121-123).