gebhart/patrepeval huggingface dataset:
The TSPO Ligands MGV-1 and 2-Cl-MGV-1 Differentially Inhibit the Cigarette Smoke-Induced Cytotoxicity to H1299 Lung Cancer Cells (2021)

TSPO is involved in cigarette smoke (CS)-induced cellular toxicity, which may result in oral and pulmonary diseases and lung cancer. H1299 lung cancer cells were exposed directly to CS. The H1299 cells were pretreated with our TSPO ligands MGV-1 and 2-Cl-MGV-1 (Ki = 825 nM for both) at a concentration of 25 µM 24 h prior to CS exposure. Cell death and apoptotic markers were measured, in addition to TSPO expression levels, ATP synthase activity, generation of reactive oxygen species (ROS), depolarization of mitochondrial membrane potential (ΔΨm), cAMP and LDH levels. Pretreatment with MGV-1 and 2-Cl-MGV-1 (25 µM), 24 h prior to CS exposure, differentially attenuated the CS-induced cellular insult as well as cell death in H1299 lung cancer cells. These protective effects included prevention of ATP synthase reversal, ROS generation, depolarization of the mitochondrial membrane and elevation in LDH. The preventive efficacy of 2-Cl-MGV-1 was superior to that achieved by MGV-1. Both ligands did not prevent the elevation in cAMP. These findings may indicate a mild protective effect of these TSPO ligands in CS-related pulmonary and keratinocyte cellular pathology.
Bioceramic Implant Induces Bone Healing of Cranial Defects (2015)

Autologous bone or inert alloplastic materials used in cranial reconstructions are techniques that are associated with resorption, infection, and implant exposure. As an alternative, a calcium phosphate-based implant was developed and previously shown to potentially stimulate bone growth. We here uncover evidence of induced bone formation in 2 patients. Histological examination 9 months postoperatively showed multinuclear cells in the central defect zone and bone ingrowth in the bone-implant border zone. An increased expression of bone-associated markers was detected. The other patient was investigated 50 months postoperatively. Histological examination revealed ceramic materials covered by vascularized compact bone. The bone regenerative effect induced by the implant may potentially improve long-term clinical outcome compared with conventional techniques, which needs to be verified in a clinical study.
Two Alpha Chains and Three Beta Chains of Human Ia Antigens (1983)

Human Ia antigens, structural and serologic analogues of murine Ia antigens, are composed of two polypeptide chains, α (34,000 MW) and β (28,000 MW). Like their murine counterparts, these polymorphic chains transiently associate with a third, invariant chain, Ii (31,000 MW) (1). These readily apparent similarities with the mouse raise questions about the genetic organization of the HLA-D region which codes for human Ia antigens. Its murine analog, the I region in the H-2 complex, is known to contain at least five genes whose products have been characterized either biochemically or serologically. In particular, two distinct populations of murine Ia antigens, I-A and I-E/C, have been analyzed and shown to be coded by two separate I region genes (2). In the past, studies based on family data and serology using conventional alloantisera indicated a considerable molecular diversity of the human Ia antigens. Development of hybridoma technology (3) and monoclonal anti-la antibodies provided specific reagents with which to try to isolate various species of human Ia antigens.
Visual Attention to the Periphery Is Enhanced in Congenitally Deaf Individuals (2000)

We compared normally hearing individuals and congenitally deaf individuals as they monitored moving stimuli either in the periphery or in the center of the visual field. When participants monitored the peripheral visual field, greater recruitment (as measured by functional magnetic resonance imaging) of the motion-selective area MT/MST was observed in deaf than in hearing individuals, whereas the two groups were comparable when attending to the central visual field. This finding indicates an enhancement of visual attention to peripheral visual space in deaf individuals. Structural equation modeling was used to further characterize the nature of this plastic change in the deaf. The effective connectivity between MT/MST and the posterior parietal cortex was stronger in deaf than in hearing individuals during peripheral but not central attention. Thus, enhanced peripheral attention to moving stimuli in the deaf may be mediated by alterations of the connectivity between MT/MST and the parietal cortex, one of the primary centers for spatial representation and attention.
Garment Refitting for Digital Characters (2020)

We present a new technique to refit garments between characters of different shapes. Our approach is based on a novel iterative scheme that alternates relaxation and rebinding optimizations. In the relaxation step, we use affine-invariant coordinates in order to adapt the input 3D garment to the shape of a target character while minimizing mesh distortion. In the rebinding step, we reset the spacing between the refitted garment and the character body controlled by user-prescribed tightness values. Our method also supports additional constraints that encode the spatial and structural arrangement of multi-layers, seams, and fold-overs. We employed this refit tool in Pixar’s feature film Soul to transfer garment pieces between various digital characters.
The Metabolomic-Gut-Clinical Axis of Mankai Plant-Derived Dietary Polyphenols (2021)

The Mankai new plant is rich in various unique potent polyphenols, potentially affecting the metabolomic-gut-clinical axis.
THE INFLUENCE OF BELT DYNAMICS ON CORNERING AND BRAKING PROPERTIES OF TYRES (1997)

Abstract The dynamic tyre behaviour is studied by means of experiments and a dynamic tyre model. To represent the tyre dynamics up to approximately 60 Hz a rigid ring model is used. The tyre-road interface is modelled using a steady state tyre model in conjunction with the relaxation length concept to describe the longitudinal and lateral force and the aligning moment generation properties of the tyre. Residual compliances are introduced to account for the large carcass deformations near the tyre contact patch. The measured frequency response functions of forces and moments with respect to the applied steering angle or brake torque are used to estimate the tyre parameters. From the experiments the total tyre relaxation length is determined as function of the level of slip and the normal load. The influence of the velocity on the natural frequencies of the belt is shown as well.
Novel Tools for Lassa Virus Surveillance in Peri-domestic Rodents (2023)

Funding for this work was supported by the National Institute of Allergy and Infectious Diseases National Institute of Health, Department of Health and Human Services under the following grants: International Collaboration in Infectious Disease Research on Lassa fever and Ebola - ICIDR - U19 AI115589, Consortium for Viral Systems Biology - CViSB - 5U19AI135995, West African Emerging Infectious Disease Research Center - WARN-ID - U01AI151812, West African Center for Emerging Infectious Diseases: U01AI151801.
The AT&t-DARPA communicator mixed-initiative spoken dialog system (2000)

The design and implementation of the AT&T Communicator mixed-initiative spoken dialog system is described.The Communicator project, sponsored by DARPA and launched in 1999, is a multi-year multi-site project on advanced spoken dialog systems research.The main focus of this paper is on issues related to the design of mixed-initiative systems.In addition to describing our architecture and implementation of the complex travel task, the paper reports on some preliminary evaluation results.
Knowledge-Guided Data-Driven Model With Transfer Concept for Battery Calendar Ageing Trajectory Prediction (2023)

Dear Editor, Lithium-ion (Li-ion) battery has become a promising source to supply and absorb energy/power for many energy-transportation applications. However, Li-ion battery capacity would inevitably degrade over time, making its related ageing prediction necessary. This letter presents effective battery calendar ageing trajectory prediction by deriving a knowledge-guided data-driven model with transfer concept. More specifically, this data-driven model is based on the support vector regression (SVR) technology. To ensure highly-accurate prognostics of battery calendar ageing trajectory under wit-nessed conditions, a knowledge-guided kernel is first developed by coupling the mechanism and empirical knowledge elements of battery storage temperature, state-of-charge (SoC), and time. To im-prove model's generalization ability under unwitnessed conditions, the knowledge-guided data-driven model is then equipped with trans-fer concept by adding a classical Gaussian kernel for all inputs. A well-rounded real battery ageing dataset under eight different storage conditions is collected to evaluate the performance of developed model. Results illustrate that this knowledge-guided battery ageing trajectory prediction model presents satisfactory accuracy for wit-nessed conditions with R2 over 0.98. After using only 20% starting capacity point to tune its transfer part, it can also generalize well for unwitnessed conditions with R2 over 0.97, further heavily reducing the required ageing experimental time and cost.
Macro-scale acousto-fluidics using bulk ultrasonic standing waves (2017)

Macro-scale acousto-fluidics involves the interaction between acoustic radiation force exerted on a particle by bulk acoustic standing waves spanning many wavelengths, fluid drag force, and the gravitational force of the particle. Parameters are particle size, and ratio of particle to fluid density and particle to fluid compressibility. Different acousto-fluidics configurations can be used to manipulate particles in multiple ways. In cell clarification, the configuration is that of a depth flow filter with the added benefit of separating the cells out of the acoustic field, thereby eliminating any issues with filter clogging or fouling. In perfusion of stirred bioreactors, the configuration resembles that of a tangential flow filter. In a third configuration, the bulk acoustic standing wave is angled relative to the fluid velocity resulting in a label-free fractionation tool. Several underlying theoretical and numerical results of acoustic radiation force and particle trajectory calculations will be presented. A theoretical framework to calculate the acoustic radiation force on spherical, spheroidal, and cylindrical particles has been developed for any particle size relative to wavelength. An analytical solution for particle deflection angle in a planar angled standing wave and uniform flow has been developed. Experimental results will be shown to support the theory.
Theoretical Modeling of Coagulation Management With Therapeutic Plasma or Prothrombin Complex Concentrate (2017)

Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship between amounts of PCC or therapeutic plasma administered, and plasma levels of FII and AT. The model showed that PCC produces substantial increases in plasma levels of FII but only small changes in AT, increasing the FII:AT ratio. Therapeutic plasma was shown to have only modest effects on levels of FII or AT, unless high doses are used.
Involvement of FAD-dependent polyamine oxidase in the metabolism of milacemide in the rat (1992)

1. It has previously been established that monoamine oxidase (MAO)-B participates in the metabolism of milacemide [2-(pentylamino)acetamide]. Furthermore, in rats, inhibition of FAD-dependent polyamine oxidase (PAO) was found to decrease the urinary excretion of two milacemide metabolites, termed UK1 and UK2. 2. Using gas chromatography-mass spectrometry, UK1 was identified as oxamic acid and UK2 as 2-hydroxyacetamide, confirming that PAO is involved in the metabolism of milacemide. 3. Thus, two FAD-dependent amine-oxidizing enzymes, MAO and PAO, contribute to the metabolism of milacemide. Milacemide appears to be the first non-polyamine xenobiotic in the metabolism of which PAO participates.
Resultados del tamiz neonatal ampliado, como nueva estrategia para la prevención de los defectos al nacimiento (2000)

Objetivo. Comunicar los resultados obtenidos en Mexico,
como el tamiz neonatal ampliado, para descubrir en recien
nacidos, aparentemente sanos, alguna de 36 enfermedades
metabolicas, y de ser posible, iniciar su
tratamiento en forma oportuna.
Material y metodos. Se obtuvieron muestras de sangre
por puncion del talon, de 7,193 recien nacidos, colectadas
en tarjetas de Guthrie, y se enviaron a Pittsburg, EUA
para su procesamiento. Se aplicaron pruebas de escrutinio
para detectar trastornos endocrinos y del metabolismo
de carbohidratos, aminoacidos, acidos organicos y acidos
grasos.
En los ninos con resultados positivos, se realizaron estudios
para confirmar el diagnostico, incluyendo el analisis
del ADN en la muestra original.
Como parte de este programa, a los enfermos diagnosticados
se les administro el tratamiento especifico.
Resultados. Se hizo el diagnostico de alguna de estas enfermedades
en 18 ninos: dos con hipotiroidismo congenito,
dos con hiperplasia suprarrenal congenita, ocho con un defecto
en el metabolismo de los hidratos de carbono, tres con
defecto de acidos organicos, uno con defecto de la oxidacion
de los acidos grasos y dos con fibrosis quistica.
El nuevo tamiz tiene mayores ventajas sobre el convencional
(basico). La prevalencia observada (22 por
10,000), indica que los padecimientos buscados con el
constituyen un problema importante en Mexico.
Liposome encapsulated vincristine: preclinical toxicologic and pharmacologic comparison with free vincristine and empty liposomes in mice, rats and dogs (1994)

A preclinical toxicology study of liposome encapsulated vincristine, free vincristine and empty liposomes was carried out in mice and dogs by single and multiple (daily for 5 days) intravenous injection. Single and multiple dose intravenous injection studies in mice showed the encapsulated form of vincristine to be less toxic than free vincristine. Empty liposomes injected intravenously into dogs were without significant toxicity. In dogs, the toxicities seen with liposomal vincristine were qualitatively similar to those of free vincristine with only minor quantitative differences. The principal toxicities of free and liposomal vincristine in dogs were anorexia, weight loss, pyrexia, myelosuppression and gastrointestinal toxicity. After single high doses of either formulation gastrointestinal toxicity was the dose-limiting toxicity, while either hematologic or gastrointestinal toxicity was dose limiting after multiple dose administration of either drug. Histopathologic lesions of importance were bone marrow atrophy, necrosis and atrophy of the lymphoproliferative tissues, necrosis of gastrointestinal tract mucosa, liver and pancreas, and hemorrhage. Distribution studies in rats showed significantly higher vincristine levels in serum, spleen, liver, trachea, jejunum, cerebrum, lung, ischiatic nerve and heart, and significantly lower levels in colon, stomach, salivary gland, thymus esophagus and pancreas after injection of the liposome-associated agent. No toxicities were seen that should preclude safe clinical trial of liposomal vincristine in man.
Nepal: A Cultural and Physical Geography. (1961)

Journal Article Nepal: A Cultural and Physical Geography Get access Nepal: A Cultural and Physical Geography. By Pradyumna P. Karan with the collaboration of William M. Jenkins. Lexington, Ind., University of Kentucky Press, 1960. 100 pp. Illus. Maps. Bibliog. $10. S. O. S. O. Search for other works by this author on: Oxford Academic Google Scholar International Affairs, Volume 37, Issue 3, July 1961, Page 402, https://doi.org/10.2307/2611037 Published: 01 July 1961
Inheritance of a common androgen synthesis variant allele is associated with female COVID susceptibility in UK Biobank (2020)

Abstract Context A sex discordance in COVID exists, with males disproportionately affected. Although sex steroids may play a role in this discordance, no definitive genetic data exist to support androgen-mediated immune suppression for viral susceptibility, nor for adrenally produced androgens. Objective The common adrenal-permissive missense-encoding variant HSD3B1 (1245C) that enables androgen synthesis from adrenal precursors and that has been linked to suppression of inflammation in severe asthma was investigated in COVID susceptibility and outcomes reported in the UK Biobank. Methods The UK Biobank is a long-term study with detailed medical information and health outcomes for over 500,000 genotyped individuals. We obtained COVID test results, inpatient hospital records, and death records and tested for associations between COVID susceptibility or outcomes and HSD3B1 (1245A/C) genotype. The outcomes were identification as a COVID case among all subjects, COVID positivity among COVID-tested subjects, and mortality among subjects identified as COVID cases. Results Adrenal-permissive HSD3B1 (1245C) genotype was associated with identification as a COVID case (odds ratio 1.11 per C allele, p = 0.00054) and COVID test positivity (OR 1.10, p = 0.0036) in older (≥ 70 years of age) women. In women identified as COVID cases, there was a positive linear relationship between age and 1245C allele frequency (p &lt; 0.0001). No associations were found between genotype and mortality. Conclusion Our study suggests that a common androgen synthesis variant regulates immune susceptibility to COVID infection in women, with increasingly strong effects as women age.
FPGA Design with Double-Gate Carbon Nanotube Transistors (2011)

Double-gate carbon nanotube field effect transistors (DG-CNTFETs) are novel devices showing an interesting property that consists of controlling the p- or n-type behavior during the device operation. This opens up the opportunity for novel design paradigms. Based on a compact physical model of these devices, we demonstrate the superiority of field-programmable gate arrays (FPGAs) designed with fine-grain DG-CNTFETs compared to FPGAs designed with traditional circuits and with coarse-grain DG-CNTFETs by 13% to 48% respectively in terms of delay.
Optical cell temperature measurements of multiple CPV technologies in outdoor conditions (2013)

It is well known that photovoltaic performance is dependent on cell temperature. Although various methods have been explored to determine outdoor concentrating photovoltaic (CPV) cell temperature, no method has proven to work across all module technologies and result in desirable uncertainties. Menard (2012) has recently published results claiming accurate measurements of cell temperature using the wavelength shift of light emitted from the sub-cells of a Semprius CPV module. This work focuses on efforts to verify Menard's results using additional CPV technologies that are on-sun at NREL. Baseline electro-luminescence emission is recorded for modules under a low level forward bias and under isothermal conditions using thermal chambers. The same modules or sister modules are then placed on NREL's high accuracy two-axis tracker for outdoor measurements. Photo-luminescence emission peaks are measured for multiple modules at stable wind and irradiance conditions. Emission results from the sub-cells are compared to what is documented in the literature for the given semiconductor material. The signal to background ratio is analyzed and the possible broad applicability of this procedure is discussed.
Rose-colored answers: neuropsychological deficits and patient-reported outcomes after stroke. (2010)

Patient-reported, subjective outcomes are promoted as a standard for ethical, valid studies in many neurological disorders. Such outcomes are considered potentially more sensitive and specific to important therapeutic effects, and may be more linked to disability and disease-related life losses than conventional assessments of impairment (e.g. ability to walk, performance on language tests, serological or radiological indices). Self-report is invaluable to identify social and emotional consequences of brain injury: depression, changes in intimate and family relationships, social role and community participation losses. However, common stroke-related neuropsychological deficits are likely to confound subjective stroke outcome measures. The scientific community focused on stroke-related health outcomes may arrive at {significantly underestimated} patient reports of stroke-related disability, caused by a failure to adjust for the effect on self-report of spatial neglect, deficits of magnitude estimation, pathologic alteration of self-awareness, and alteration in distributed cortical systems supporting emotional semantics and abstraction.
141 PBMC-based cancer vaccines generated with microfluidics squeezing demonstrate synergistic and durable tumor reduction in combination with PD1 checkpoint and FAP targeted IL-2 variants (2020)

<h3>Background</h3> We engineered unfractionated peripheral blood mononuclear cells (PBMCs) to function as antigen presenting cells (APCs) that generate potent CD8+ T cell responses. We investigated the combined efficacy of PBMC-based cancer vaccine with targeted interleukin 2 variants (IL2v); anti-Programmed Cell Death Protein 1 (muPD1-IL2v) and anti-Fibroblast Activation Protein (muFAP-IL2v). <h3>Methods</h3> We generated PBMC-based cancer vaccine with microfluidic cell engineering system (Cell Squeeze®), which facilitates direct cytosolic antigen delivery and enables cell subsets within PBMCs to function as APCs. The immunocytokines used contain IL2v fused with antibody counterparts that enable targeting to tumor-associated stroma or immune cells (aFAP and aPD-1, respectively) with modified FcR binding. The IL2v moiety, compared with wild-type IL-2, has abolished binding to IL-2Ra (CD25) resulting in IL-2Rgb binding only, thus fully maintaining activity on NK and CD8+ T cells, while avoiding Treg activity and CD25 mediated toxicity. <h3>Results</h3> In the murine TC-1 HPV tumor model, SQZ-PBMC-based vaccines show efficacy as monotherapy (1e6 cells administered iv on day 14 post-tumor implant), while SQZ combination therapy with targeted immunocytokines, muPD1-IL2v and muFAP-IL2v (2 mg/kg or 1 mg/kg, respectively, administered iv on days 21, 28, and 35 post-tumor implant) significantly delayed tumor growth and improved survival in murine TC-1 HPV tumor model. Median survival of combination treated groups remained undefined at day 84 post-tumor implant, while the monotherapy treated groups had calculated median survival times of 36.5, 42, and 70 days for the muFAP-IL2v, muPD1-IL2v, and SQZ monotherapy groups, respectively. Following initial tumor clearance, tumor-free mice (2/12 animals for SQZ monotherapy; 8/12 animals for SQZ with muFAP-IL2v; 11/11 animals for SQZ with muPD1-IL2v) were all re-challenged at day 84 and all remained tumor free at least 7 weeks post re-challenge, suggesting the generation of anti-tumor memory response. In a mechanistic study, SQZ-PBMCs in combination with muPD1-IL2v resulted in increased expansion of intra-tumoral, antigen-specific CD8+ T cells compared with separate administration of either therapy (~3.6-fold over SQZ alone; ~2000-fold over muPD1-IL2v alone; per mg of tumor). Combination therapy also resulted in improved IFNγ and TNFα cytokine production by SQZ-elicited CD8+ T cells (~1.7-fold and ~9-fold, respectively, over SQZ monotherapy). <h3>Conclusions</h3> Monotherapy with SQZ-PBMC-based cancer vaccines can drive anti-tumor responses in murine systems. These responses are enhanced by combined administration of targeted immunocytokines. Monotherapy with SQZ-PBMC-HPV is currently under clinical evaluation for HPV16+ tumor indications. These preclinical data support the combination of SQZ-PBMC with FAP-IL2v or PD1-IL2v targeted immunocytokine as promising cancer immunotherapies.