gebhart/patrepeval huggingface dataset:
A Convenient Late‐Stage Fluorination of Pyridylic C−H Bonds with N‐Fluorobenzenesulfonimide (2016)

Abstract Pyridine features prominently in pharmaceuticals and drug leads, and methods to selectively manipulate pyridine basicity or metabolic stability are highly sought after. A robust, metal‐free direct fluorination of unactivated pyridylic C−H bonds was developed. This convenient reaction shows high functional‐group tolerance and offers complimentary selectivity to existing C−H fluorination strategies. Importantly, this late‐stage pyridylic C−H fluorination provides opportunities to rationally modulate the basicity, lipophilicity, and metabolic stability of alkylpyridine drugs.
Antibodies to the cytoplasm, cell membrane and nuclear membrane of malignant neoplasms in pooled normal human polyspecific immunoglobulin G. (1999)

IVIg is a preparation of normal polyspecific IgG obtained from pooled plasma of a large number of healthy donors. IVIg treatment of patients with chronic lymphocytic leukemia induced a reduction in the total number of lymphocytes in the peripheral blood. Regression of Kaposi's sarcoma was also noted in an HIV patient treated with IVIg. The aim of this study was to determine whether F(ab')2 prepared from IVIg binds to cellular structures of different tumor tissues. Biotinylated F(ab')2 was prepared from 3 different preparations of IVIg and from affinity purified IgG from a patient with multiple myeloma. Direct immunohistochemistry using a streptavidin peroxidase staining method was performed on biopsy samples of 18 different tumor tissues. Positive staining of the cytoplasm, cell membrane and nuclear membrane of several types of malignant tumors by F(ab')2 from IVIg was immunohistochemically demonstrated. Nuclear staining of tumor cells by IVIg was rare. IVIg bound to different tumors of epithelial origin, especially colon carcinoma, breast carcinoma and squamous cell carcinoma of the lung. Malignant tumors of mesenchymal origin such as leiomyosarcoma have also demonstrated positive staining by IVIg. IVIg contains antibodies to the cytoplasm, nuclear membrane and cell membrane of different malignant tumors especially of epithelial origin. This binding might provide a basis for the assumption that IVIg treatment of cancer patients may induce antibody dependent cell mediated cytotoxicity response against tumors, and implies that it can be potentially beneficial as adjuvant treatment of malignant diseases.
Manipulation of live mouse embryonic stem cells using holographic optical tweezers (2009)

We report the ability to move and arrange patterns of live embryonic stem cells using holographic optical tweezers. Single cell suspensions of mouse embryonic stem cells were manipulated with holographic optical tweezers into a variety of patterns including lines, curves and circles. Individual cells were also lifted out of the sample plane highlighting the potential for 3D positional control. Trypan blue dye exclusion and Live/Dead™ staining (CMFDA−1, EthHD−1) showed that the cells were still viable after manipulation with the optical tweezers. The ability to move individual stem cells into specific, pre-defined patterns provides a method to study how arrangement and associated small-scale interactions occur between neighbouring cells.
Validation of Positive Fraction Vector Fitting Algorithm in the identification of Passive Immittances (2026)

The paper deals with the problem of identification of guaranteed passive rational models for linear distributes structures. The identification is pursued in two separate steps: in the first step the Vector Fitting algorithm is used for the identification of the poles; then the identification of residues is formulated as a convex programming problem with constraints on single terms of the pole-residue expansion. This approach, although suboptimal, is easier than constraining passivity on the whole transfer function, and at the same time more rigorous than perturbative approaches. In the paper the procedure is validated in reference cases and comparatively evaluated vs. other existing passivity enforcement schemes.
Distributed sequential detection for Gaussian binary hypothesis testing: Heterogeneous networks (2014)

This paper studies the problem of sequential Gaussian binary hypothesis testing in a distributed multi-agent heterogeneous network. A distributed sequential detection algorithm of the consensus+innovations form is proposed, in which the agents update their decision statistics by simultaneously processing latest observation samples (innovations) and neighborhood information. For each pre-specified set of error probabilities, algorithm parameters are derived which ensure that the algorithm achieves the desired error performance and finite time termination almost surely. The expected stopping time for the proposed algorithm is evaluated and its dependance on network connectivity quantified. Finally, simulation studies are presented which illustrate the analytical findings.
Superplastic forming of stainless steel automotive components (1997)

Exhaust emission standards are governmentally controlled standards, which are increasingly stringent, forcing alternate strategies to meet these standards. One approach to improve the efficiency of the exhaust emission equipment is to decrease the time required to get the catalytic converter to optimum operating temperature. To accomplish this, automotive manufacturers are using double wall stainless steel exhaust manifolds to reduce heat loss of the exhaust gases to the converter. The current method to manufacture double wall stainless steel exhaust components is to use a low-cost alloy with good forming properties and extensively form, cut, assemble, and weld the pieces. Superplastic forming (SPF) technology along with alloy improvements has potential at making this process more cost effective. Lockheed Martin Energy Systems (LMES), Lawrence Livermore National Laboratory (LLNL) and USCAR Low Emission Partnership (LEP) worked under a Cooperative Research And Development Agreement (CRADA) to evaluate material properties, SPF behavior, and welding behavior of duplex stainless steel alloy for automotive component manufacturing. Battelle Pacific Northwest National Laboratory (PNNL) has a separate CRADA with the LEP to use SPF technology to manufacture a double wall stainless steel exhaust component. As a team these CRADAs developed and demonstrated a technical plan to accomplish making double wall stainless steel exhaust manifolds.
The proof of concept for 3-cm Altimetry using the Paris Interferometric Technique (2010)

A proof-of-concept instrument for PARIS-IOD, based on a full-custom dedicated GNSS-Reflections receiver has been developed, and the novel interferometric concept tested in several experiments using signals generated by a SPIRENT equipment. The preliminary analysis has resulted in the detection of 1-cm delay-jumps, using 33 group-delay observables of 1 second, with an associated dispersion of the order of 2-cm. A signal-to-noise degradation of the order of ~3 dB with respect to the one expected for the Bridge Experiment would keep the 1-second sigma error below 3-cm.
Performance Evaluation Of A Centrifugal Compressor Operating Under Wet Gas Conditions. (2005)

This paper presents the results of performance testing of a single-stage centrifugal compressor operating under wet gas conditions.The test was performed at an oil and gas operator's test facility and was executed at full-load and full-pressure conditions using a mixture of hydrocarbon gas and hydrocarbon condensate.The effect of liquid was investigated by changing the gas-volume fraction between 1.0 and 0.97, which covers the range encountered by the operator during regular gas/condensate field production in the North Sea.Other parameters that were evaluated include the 111
A Comparative Plasmonic Study of Nanoporous and Evaporated Gold Films (2008)

Previously, we have reported that nanoporous gold (NPG) films prepared by a chemical dealloying method have distinctive plasmonic properties, i.e., they can simultaneously support localized and propagating surface plasmon resonance modes (l-SPR and p-SPR, respectively). In this study, the plasmonic properties of NPG are quantified through direct comparison with thermally evaporated gold (EG) films. Cyclic voltammetry and electrochemical impedance spectroscopy experiments reveal that the NPG films have 4-8.5 times more accessible surface area than EG films. Assemblies of streptavidin-latex beads generate p-SPR responses on both NPG and EG films that correlate well with the bead density obtained from scanning electron microscopy (SEM) images. A layer-by-layer assembly experiment on NPG involving biotinylated anti-avidin IgG and avidin, studied by l-SPR and SEM, shows that the l-SPR signal is directly linked to the accessibility of the interior of the NPG porosity, an adjustable experimental parameter that can be set by the dealloying condition and time. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11468-007-9048-5) contains supplementary material, which is available to authorized users.
Second-Order Optic Flow Deficits in Amblyopia (2007)

Global motion impairment appeared to have a high-level binocular locus and was independent of the depth of the contrast deficit. Results also support the idea that global motion and optic flow processing are form-cue invariant.
The Copper Transport Protein Atox1 Promotes Neuronal Survival (2000)

Atox1, a copper transport protein, was recently identified as a copper-dependent suppressor of oxidative damage in yeast lacking superoxide dismutase. We have previously reported that Atox1 in the rat brain is primarily expressed in neurons, with the highest levels in distinct neuronal subtypes that are characterized by their high levels of metal, like copper, iron, and zinc. In this report, we have transfected the Atox1 gene into several neuronal cell lines to increase the endogenous level of Atox1 expression and have demonstrated that, under conditions of serum starvation and oxidative injury, the transfected neurons are significantly protected against this stress. This level of protection is comparable with the level of protection seen with copper/zinc superoxide dismutase and the anti-apoptotic gene bcl-2 that had been similarly transfected. Furthermore, neuronal cell lines transfected with a mutant Atox1 gene, where the copper binding domain has been modified to prevent metal binding, do not afford protection against serum starvation resulting in apoptosis. Therefore, Atox1 is a component of the cellular pathways used for protection against oxidative stress.
ChemInform Abstract: Formamide Assisted One‐Pot Conversion of Aromatic Aldehydes into the Corresponding Nitriles. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Magnetorheological Fluid in Oscillatory Shear and Parameterization with Regard to MR Device Properties (2009)

Storage and loss moduli of an MRF submitted to a magnetic field, as measured by a plate—plate magnetorheometer versus shear amplitude in oscillatory shear, exhibit a complex non-linear response. Above a critical amplitude, the storage modulus decreases strongly, while the loss modulus passes through a distinct maximum. The periodic shear stress signal changes from sinusoidal to saw-tooth like. A mechanical analogue, consisting of a Bingham element (friction element and damper arranged in parallel) and elastic spring in series, is capable to capture the measured behaviour. Model predictions for the time-dependent shear stress and resulting moduli at agitation frequency (fundamental mode) for various amplitudes are discussed and the determination of model parameters from the experimental data is addressed. The linear radial shear strain profile in plate—plate geometry causes a smearing of the moduli and shift to higher amplitudes by about a factor of 4/3. The conversion from physical to engineering parameters for an MR device is demonstrated for disk clutches using cone—plate and plate—plate geometry. Complications due to a nonhomogeneous shear in the device are addressed. The elastic modulus of the MRF may be relevant for vibration damping and may cause some shift in the resonance frequency of the device.
Ultrafast dynamic imaging of thermal and acoustic dynamics in nanosystems using a tabletop high harmonic source (2019)

We demonstrate the first stroboscopic full-field EUV nanoscope using high harmonics. We image the propagation of thermal and surface acoustic waves in nickel with 80nm transverse, 0.5 Å axial, and 10 fs resolution.
Message-based microkernel for real-time system (2003)

This paper describes the design and implementation of the basic primitives and major components of the message-based microkernel for real-time systems to find out its shortcomings and ways to improve them. The real-time OS with message-based microkernel enables a user to add or change the system services easily for special purposes. But it has rather large overhead of interrupt latency and system call due to the message copy and synchronization. In order to support true real-time performance, kernel preemption and efficient message exchange mechanism is required.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Design and implementation of dynamic near-infrared optical tomographic imaging instrumentation for simultaneous dual-breast measurements (2005)

Dynamic near-infrared optical tomographic measurement instrumentation capable of simultaneous bilateral breast imaging, having a capability of four source wavelengths and 32 source-detector fibers for each breast, is described. The system records dynamic optical data simultaneously from both breasts, while verifying proper optical fiber contact with the tissue through implementation of automatic schemes for evaluating data integrity. Factors influencing system complexity and performance are discussed, and experimental measurements are provided to demonstrate the repeatability of the instrumentation. Considerations in experimental design are presented, as well as techniques for avoiding undesirable measurement artifacts, given the high sensitivity and dynamic range (1:10(9)) of the system. We present exemplary clinical results comparing the measured physiologic response of a healthy individual and of a subject with breast cancer to a Valsalva maneuver.
Exhaust valve profile modulation for improved diesel engine curb idle aftertreatment thermal management (2021)

Rapid warm-up of a diesel engine aftertreatment system (ATS) is a challenge at low loads. Modulating exhaust manifold pressure (EMP) to increase engine pumping work, fuel consumption, and as a result, engine-outlet temperature, is a commonly used technique for ATS thermal management at low loads. This paper introduces exhaust valve profile modulation as a technique to increase engine-outlet temperature for ATS thermal management, without requiring modulation of exhaust manifold pressure. Experimental steady state results at 800 RPM/1.3 bar BMEP (curb idle) demonstrate that early exhaust valve opening with negative valve overlap (EEVO+NVO) can achieve engine-outlet temperature in excess of 255°C with 5.7% lower fuel consumption, 12% lower engine out NO x and 20% lower engine-out soot than the conventional thermal management strategy. Late exhaust valve opening with internal EGR via reinduction (LEVO+Reinduction) resulted in engine-outlet temperature in excess of 280°C, while meeting emission constraints at no fuel consumption penalty. This work also demonstrates that LEVO in conjunction with modulation of exhaust manifold pressure results in engine-outlet temperature in excess of 340°C while satisfying desired emission constraints. Aggressive use of LEVO can result in engine-outlet temperatures of 460°C, capable of active regeneration of DPF at curb idle, without the significant increase in engine-out soot emissions seen in previously studied strategies.
Protein Engineering of the 4-Methyl-5-Nitrocatechol Monooxygenase from Burkholderia sp. Strain DNT for Enhanced Degradation of Nitroaromatics (2006)

4-Methyl-5-nitrocatechol (4M5NC) monooxygenase (DntB) from Burkholderia sp. strain DNT catalyzes the second step of 2,4-dinitrotoluene degradation by converting 4M5NC to 2-hydroxy-5-methylquinone with the concomitant removal of the nitro group. DntB is a flavoprotein that has a very narrow substrate range. Here, error-prone PCR was used to create variant DntB M22L/L380I, which accepts the two new substrates 4-nitrophenol (4NP) and 3-methyl-4-nitrophenol (3M4NP). At 300 microM of 4NP, the initial rate of the variant expressing M22L/L380I enzyme (39 +/- 6 nmol/min/mg protein) was 10-fold higher than that of the wild-type enzyme (4 +/- 2 nmol/min/mg protein). The values of kcat/Km of the purified wild-type DntB enzyme and purified variant M22L/L380I were 40 and 450 (s(-1) M(-1)), respectively, which corroborates that the variant M22L/L380I enzyme has 11-fold-higher efficiency than the wild-type enzyme for 4NP degradation. In addition, the variant M22L/L380I enzyme has fourfold-higher activity toward 3M4NP; at 300 microM, the initial nitrite release rate of M22L/L380I enzyme was 17 +/- 4 nmol/min/mg protein, while that of the wild-type enzyme was 4.4 +/- 0.7 nmol/min/mg protein. Saturation mutagenesis was also used to further investigate the role of the individual amino acid residues at positions M22, L380, and M22/L380 simultaneously. Mutagenesis at the individual positions M22L and L380I did not show appreciable enhancement in 4NP activity, which suggested that these two sites should be mutated together; simultaneous saturation mutagenesis led to the identification of the variant M22S/L380V, with 20% enhanced degradation of 4NP compared to the variant M22L/L380I. This is the first report of protein engineering for nitrite removal by a flavoprotein.
RELATIONSHIP BETWEEN WALL PRESSURE FLUCTUATIONS AND STREAMWISE VORTICITY IN A TURBULENT BOUNDARY LAYER (2001)

A direct numerical simulation is performed to obtain the correlation between wall pressure fluctuations and streamwise vorticities in a spatially-developing turbulent boundary layer. It is shown that wall pressure fluctuations are related with the upstream streamwise vortices in the buffer region. The maximum correlation occurs with the spanwise displacement from the location of wall pressure fluctuations. The conditionally-averaged vorticity field and the quadrant analysis of Reynolds shear stress indicate that positive wall pressure fluctuations are correlated with the sweep events due to streamwise vortices, while negative wall pressure fluctuations are created beneath the ejection events and vortex cores.
ChemInform Abstract: 3R‐Hydroxymuscarine from L‐Rhamnose without Protection. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optimal load sharing of parallel compressors via modifier adaptation (2016)

We discuss optimal load sharing of parallel gas compressors in the presence of plant-model mismatch. We formulate this problem as a static real-time optimization task and propose to tackle it by means of modifier adaptation. Under mild assumptions, the chosen approach guarantees optimal operating conditions upon convergence. Furthermore, we discuss how the specific problem structure can be exploited to estimate the plant gradients efficiently during process operation. Finally, we draw upon simulated case studies for two and six compressors to demonstrate the applicability and effectiveness of the proposed real-time optimization approach.
Combined Modality Treatment with Intensified Chemotherapy and Dose-Reduced Involved Field Radiotherapy in Patients with Early Unfavourable Hodgkin Lymphoma (HL): Final Analysis of the German Hodgkin Study Group (GHSG) HD11 Trial. (2009)

Abstract Abstract 717 Purpose: Combined modality treatment consisting of 4 cycles of chemotherapy (CT) followed by involved field radiotherapy (IF-RT) is the standard treatment for early unfavourable HL. In our prior trial for this group of patients (HD8), overall survival (OS) and freedom from treatment failure (FFTF) at 5 years were 91% and 83%, respectively. The HD11 trial thus addressed two major questions: (1) improving outcome by intensifying CT (4xABVD vs. 4xBEACOPPbaseline; Bbas) and (2) defining the best radiation dose (30Gy vs. 20Gy IF-RT). Patients and methods: Between May 1998 and January 2003, 1395 eligible patients aged 16–75 years with untreated early unfavourable stage HL (CS I, IIA with at least one of the risk factors large mediastinal mass (a), extranodal disease (b), elevated ESR (c) or ≥ 3 nodal areas (d); IIB with risk factors c and/or d) were randomized into one of the following 4 treatment arms: 4xABVD + 30Gy (A), 4xABVD + 20Gy (B), 4x Bbas + 30Gy (C) or 4x Bbas + 20Gy (D). Since there are strong indications for an interaction between CT- and RT-doses, a comparison of pooled treatment arms (A+B vs. C+D for comparison of 4×ABVD vs. 4× Bbas and A+C vs. B+D for comparison of 30Gy IF-RT vs. 20Gy IF-RT) would be misleading. Therefore all treatment arms were analysed separately. Results: Patient characteristics were well balanced between the 4 arms (median age 33 years, 49% male, 6% stage I, 29% B-symptoms). CT- and RT-related acute toxicity occurred significantly more often in the arms with the more intensive therapy (CT: 74.1% vs. 51.8%; RT: 12.3% vs. 5.5%). The complete remission rate 3 months after end of therapy was 94.1% for the whole group and did not differ significantly between the 4 arms. The 5-year estimate of FFTF (primary endpoint) is 85.0% (OS 94.5%, PFS 86.0%). Bbas is more effective than ABVD if followed by 20Gy IF-RT (5y-FFTF difference 5.7%, 95%-CI [0.1%; 11.3%]). This effect does not exist in combination with 30Gy IF-RT (5y-FFTF difference 1.6% [-3.6%; 6.9%]). Similar results are observed for the RT-question: After 4 cycles of Bbas, 20Gy is not inferior to 30Gy (5y-FFTF difference -0.1%, 95%-CI [-5.1%; 4.9%]), whereas after 4xABVD, a relevant inferiority of 20Gy cannot be excluded (-4.0% [-9.5%; 1.4%]). Conclusion: A reduction of RT dose from 30Gy to 20Gy IF-RT seems to be justified only in combination with Bbas, but not with a less effective chemotherapy such as 4xABVD. Patients will benefit from an intensified CT such as Bbas only in combination with 20Gy IF-RT but not with 30Gy IF-RT. Disclosures: No relevant conflicts of interest to declare.
Polarization selective, graded-reflectivity resonance filter, using a space-varying guided-mode resonance structure (2010)

We designed, fabricated, and tested, polarization selective, graded-reflectivity resonant filters; based on a radial-gradient spatially-distributed, guided-mode resonance device architecture. The demonstrated filters have polarized spectral-resonance responses, distributed across their aperture extent, in the range between 1535 nm and 1540 nm wavelengths. Spectral sensitivity was observed on device tests, for wavelength changes as low as 0.2 nm. Using multiple lithographic exposures and biasing exposure methods, the devices were engineered to have a sub-aperture region, with no hard boundaries or diffraction anomalies.
Reperfused Myocardial Infarction as Seen with Use of Necrosis-specific versus Standard Extracellular MR Contrast Media in Rats (1999)

The sizes of hyperenhanced regions displayed by using mesoporphyrin and gadopentetate dimeglumine differed from each other. The difference in size of the hyperenhanced region demarcated by mesoporphyrin and gadopentetate dimeglumine may provide an estimation of potentially salvageable myocardium.