gebhart/patrepeval huggingface dataset:
Abstract 19432: Neuronal Isoform of Nitric Oxide Synthase is Upregulated in Cardiac Intrinsic, and Extrinsic Sympathetic Afferent and Efferent Ganglia Following Myocardial Infarction (2015)

Objective: The impact of myocardial infarction (MI) on neuronal nitric oxide synthase (nNOS), an important mediator of cardiac neurotransmission is not well understood. Methods: Yorkshire pigs (n=10) underwent anterior MI by LAD occlusion. After 6-8 weeks, bilateral stellate ganglia (SG), T1 dorsal root ganglia (DRG), right atrial (RAGP) and ventral inter-ventricular ganglionated plexi (VIVGP)were extracted, formalin-fixed, paraffin-embedded, and sectioned. Immno-staining for nNOS was performed on representative slides through the middle of the ganglia, and for calcitonin-gene related peptide (CGRP), a marker of sensory afferent neurons. The percentage of immunoreactive (IR) neurons was quantified. Results: An average of 63.1±40.7, 169.7±55.5, and 448.1±204.5 neurons were counted in the GPs, DRG, and SG respectively. There was no significant difference in the number of neurons counted in controls vs MIs. In the GPs, nNOS was differentially altered by MI, with significant upregulation in VIVGP but not RAGP of MI (13.8±2.8% vs 46.6±5.3%, p&lt;0.001; and 12.1±3.6% vs 12.5±2.9%, p=NS, respectively) compared to control animals. In the DRG, IR of both CGRP and nNOS was increased (36.3±6.2% vs 65.3±4.8%, p&lt;0,001 for nNOS; and 64.1±6.2% vs 85.2±5.6%, p&lt;0.001 for CGRP), with increased co-expression of both CGRP and nNOS in approximately 20% of DRG neurons. In the SG, the number of neurons demonstrating strong IR for nNOS was approximately 0.4% in control animals. After MI, this increased 8-fold to 3.12% (P&lt;0.01). Conclusions: nNOS expression is upregulated differentially following MI in the GPs, with increased expression in the ventricular GP innervating the region of MI, but not in the RAGP. Both cardiac sympathetic afferent (DRG) neurons, and efferent (SG) neurons increase expression of nNOS following MI. The impact of nNOS in these different sites warrants further investigation.
A robust multi-conductor transmission line model to simulate EM transients in underground cables (2009)

This paper introduces a new mesh-domain model to simulate time-domain transients in underground cables accurately considering frequency dependent effects. The model is formulated in mesh domain using mesh voltages and currents. The advantages of the mesh domain is that mesh currents and voltages in co-axial cables are naturally decoupled at high frequencies, so that the mesh domain functions (characteristic admittance, propagation functions etc.) behave smoothly compared with phase domain functions. The transformation matrices between mesh and phase domain are real and constant. The paper validates the proposed model by comparing the time domain simulations with solution obtained using inverse Laplace transform method for simple linear terminations.
C5H4:  Pyramidane and Its Low-Lying Isomers (2001)

The chemistry of the C5H4 singlet potential energy surface was investigated at sophisticated levels of theory with a focus on the stability of pyramidane (tetracyclo[2.1.0.01,302,5]pentane or [3.3.3.3]fenestrane), a structure featuring a carbon atom at the apex of a square pyramid. Zero-point corrected relative energetics were predicted with both coupled cluster and density functional methodologies. Computations with both methodologies agree qualitatively with previous theoretical results, demonstrating that the pyramidane structure is a true minimum with substantial barriers to isomerization. At the CCSD(T)/TZ2P level a relative energy of 24 kcal/mol was predicted for the transition state to tricyclo[2.1.0.02,5]pent-3-ylidene, the lowest barrier to isomerization of pyramidane. The transition state to bicyclo[2.1.0]pent-2-ene-5-ylidene, the other transition state known to lead directly to the pyramidane structure, was found to lie 33 kcal/mol above pyramidane. Relative energies are also provided for several lower-lying C5H4 isomers, including isomers incorporating linear carbon chains.
Towards passive 6D reflectance field displays (2008)

Traditional flat screen displays present 2D images. 3D and 4D displays have been proposed making use of lenslet arrays to shape a fixed outgoing light field for horizontal or bidirectional parallax. In this article, we present different designs of multi-dimensional displays which passively react to the light of the environment behind. The prototypes physically implement a reflectance field and generate different light fields depending on the incident illumination, for example light falling through a window. We discretize the incident light field using an optical system, and modulate it with a 2D pattern, creating a flat display which is view and illumination-dependent. It is free from electronic components. For distant light and a fixed observer position, we demonstrate a passive optical configuration which directly renders a 4D reflectance field in the real-world illumination behind it. We further propose an optical setup that allows for projecting out different angular distributions depending on the incident light direction. Combining multiple of these devices we build a display that renders a 6D experience, where the incident 2D illumination influences the outgoing light field, both in the spatial and in the angular domain. Possible applications of this technology are time-dependent displays driven by sunlight, object virtualization and programmable light benders / ray blockers without moving parts.
ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle (2022)

Mechanical inputs give rise to p38 and JNK activation, which mediate adaptive physiological responses in various tissues. In skeletal muscle, contraction-induced p38 and JNK signaling ensure adaptation to exercise, muscle repair, and hypertrophy. However, the mechanisms by which muscle fibers sense mechanical load to activate this signaling have remained elusive. Here, we show that the upstream MAP3K ZAKβ is activated by cellular compression induced by osmotic shock and cyclic compression in vitro, and muscle contraction in vivo. This function relies on ZAKβ's ability to recognize stress fibers in cells and Z-discs in muscle fibers when mechanically perturbed. Consequently, ZAK-deficient mice present with skeletal muscle defects characterized by fibers with centralized nuclei and progressive adaptation towards a slower myosin profile. Our results highlight how cells in general respond to mechanical compressive load and how mechanical forces generated during muscle contraction are translated into MAP kinase signaling.
Estructura tridimensional de un fragmento de 3 Kda del factor derivado de Plaquetas-4 con actividad antiangiogénica e interacción con el factor de crecimiento para fibroblastos (2002)

Platelet-Factor-4 is a protein belonging to the family of ELR negative CXC chemokines which binds to fibroblast growth factor, and inhibits its mitogenic activity.Platelet-factor-4 also inhibits tumor growth by mechanisms involving antiangiogenesis in which the blockage of fibroblast growth factor mitogenic activity seems lo play an essential role. Synthesis of platelet-factor-4 by recombinant technologies is a considerably cumbersome process that does not seen could sustain an industrial production of pharmacological-quoality because of platelet-factor-4 quaternary structure, and because the protein activation requires an intramonomer Hydrolisys. It has been shown that the protein's twenty-four residue C-terminal fragment is also antiangtogenic in vitro and in vivio, forms a specific 1:1 complex with fibroblast growyh factors and decreases their affinity for their cell surface receptor. Thus this fragments seems could constitute an alternative to the use of the whole platelet-factor-4 for several of its uses therapeutic applications. The fragments preferential three-dimensional conformation in solution is quite stable and has been found to be composed of two helical sub-domains, which, both, seem required for inhihilion of fibroblast growth factor driven mitogenesis. The characteritation, at high resolution, of the three-dimensional structure of this fragment may contribute, to the understanding of the basis of its antiangiogenic activity, and thus, contribute, to the optimitation of their pharmacological properties. At the same time this structural characteritation may also contribute to a deeper perception of the platelet-factor-4 physiology.
Depletion-mode polysilicon optical modulators in a bulk CMOS process (2013)

We demonstrate the first depletion-mode modulators in polysilicon bulk CMOS. They use a new, wiggler-mode microcavity for process compatibility with fully-etched silicon and lateral pn junctions. We show 4.2dB extinction and 60fJ energy/bit at 5Gbps.
ROBOTS IN HEALTH CARE (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTROBOTS IN HEALTH CARECite this: Anal. Chem. 1991, 63, 14, 741A–747APublication Date (Print):July 15, 1991Publication History Published online30 May 2012Published inissue 15 July 1991https://doi.org/10.1021/ac00014a732RIGHTS & PERMISSIONSArticle Views105Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (6 MB) Get e-Alerts Get e-Alerts
A New Method for Rapid Screening of End-Point PCR Products: Application to Single Genome Amplified HIV and SIV Envelope Amplicons (2015)

PCR is the most widely applied technique for large scale screening of bacterial clones, mouse genotypes, virus genomes etc. A drawback of large PCR screening is that amplicon analysis is usually performed using gel electrophoresis, a step that is very labor intensive, tedious and chemical waste generating. Single genome amplification (SGA) is used to characterize the diversity and evolutionary dynamics of virus populations within infected hosts. SGA is based on the isolation of single template molecule using limiting dilution followed by nested PCR amplification and requires the analysis of hundreds of reactions per sample, making large scale SGA studies very challenging. Here we present a novel approach entitled Long Amplicon Melt Profiling (LAMP) based on the analysis of the melting profile of the PCR reactions using SYBR Green and/or EvaGreen fluorescent dyes. The LAMP method represents an attractive alternative to gel electrophoresis and enables the quick discrimination of positive reactions. We validate LAMP for SIV and HIV env-SGA, in 96- and 384-well plate formats. Because the melt profiling allows the screening of several thousands of PCR reactions in a cost-effective, rapid and robust way, we believe it will greatly facilitate any large scale PCR screening.
Li-Ion Conductive Phosphate Glass Synthesized by Using Ion Exchange (2012)

To obtain Li-ion conductive glass materials, we synthesized SiO2-ZrO2-P2O5-Li2O glasses by Li+/Na+ ion exchange on Na-ion conducting SiO2-ZrO2-P2O5-Na2O glasses. The maximum ionic conductivity for Na-type phosphate glasses is 6.2 × 10-7, while that for Li-ion-exchanged phosphate glass is 5.5 × 10-5 S/cm at room temperature. The Li-ion phase obtained by ion exchange exhibited conductivities 1-4 orders of magnitude higher than that of the corresponding Na-ion phase. This may be attributed to the smaller size of Li+. Ion exchange is a useful technique for producing highly ionic glass electrolytes.
Ultra-thin, high-resolution, flexible electronic ink displays addressed by a-Si active-matrix TFT backplanes on stainless steel foil (2003)

Ultra-thin, flexible displays were fabricated using electronic ink and a-Si TFT backplanes on stainless steel foil substrates. The fabricated TFTs have a linear mobility of 0.5 cm/sup 2//Vs and an ON/OFF ratio of 5/spl times/10/sup 6/. TFT characteristics under bias-temperature-stress and mechanical stress are discussed. These 0.3 mm thick displays have 96 dpi resolution, with 160/spl times/240 pixels on a 3.1" diagonal active area. Near 180/spl deg/ viewing angle and a contrast ratio of 8.5:1 were achieved.
Automaticin vivoportal dosimetry of all treatments (2013)

At our institution EPID (electronic portal imaging device) dosimetry is routinely applied to perform in vivo dose verification of all patient treatments with curative intent since January 2008. The major impediment of the method has been the amount of work required to produce and inspect the in vivo dosimetry reports (a time-consuming and labor-intensive process). In this paper we present an overview of the actions performed to implement an automated in vivo dosimetry solution clinically. We reimplemented the EPID dosimetry software and modified the acquisition software. Furthermore, we introduced new tools to periodically inspect the record-and-verify database and automatically run the EPID dosimetry software when needed. In 2012, 95% of our 3839 treatments scheduled for in vivo dosimetry were analyzed automatically (27,633 portal images of intensity-modulated radiotherapy (IMRT) fields, 5551 portal image data of VMAT arcs, and 2003 portal images of non-IMRT fields). The in vivo dosimetry verification results are available a few minutes after delivery and alerts are immediately raised when deviations outside tolerance levels are detected. After the clinical introduction of this automated solution, inspection of the detected deviations is the only remaining work. These newly developed tools are a major step forward towards full integration of in vivo EPID dosimetry in radiation oncology practice.
Analytical Approaches Towards Understanding Structure-Property Relationships in End-Linked Model PDMS Networks (2012)

Abstract not provided
Fabrication of Ge micro-disks on free-standing SiO2 beams for monolithic light emission (2015)

Realizing a germanium (Ge)-based monolithic light source requires high n-type doping, tensile strain, and an optical cavity. Here, we demonstrate the application of spin-on doping technique, and the use of free-standing structures to induce tensile strain on Ge micro-disks, which act as a simple micro-cavity.
Time gap accounted video scene segmentation with modified mean-shift X-means clustering (2017)

This paper introduces a modified clustering method derived from a combination of mean-shift and x-mean clustering concepts to segment videos in a basic unit of scenes. The proposed clustering method takes account of time differences of images to cluster them into an unset number of groups. The performance of the proposed method was compared to mean-shift and x-means clustering methods. The introduced method is efficient in time and calculation and it is able to separately cluster images with same or similar features but with time differences.
Ryegrass genes- a potential source for improving rice and grass species (2010)

Perennial ryegrass (Lolium perenne L.) is the most important pasture grass for meat, dairy and wool production in New Zealand, covering more than 7 million hectares. Due to its high self-incompatible nature, genetic improvement of this species has proven difficult thorough conventional breeding methods. Genomics is a tool that will help accelerate the improvements to ryegrass in traits recalcitrant to traditional conventional breeding. These traits include increased biomass, improved digestibility and enhanced drought tolerance. With this as our goal, we carried out a SAGE based transcriptome program in perennial ryegrass from livestock active paddocks and laboratory raised plants (Sathish et al., 2007). The SAGE tags were mapped to our proprietary methyl-filtered (GeneThresher®) perennial ryegrass genome sequence database. Genes and promoters were selected based on the transcriptome data and were functionally tested in transgenic rice, using the services of a commercial research lab - MetaHelix in Bangalore, India. We have identified ryegrass genes that confer increased shoot biomass in rice and ryegrass gene promoters that are constitutively expressed in transgenic rice. Leads from the functional testing are being fed into the perennial ryegrass Cisgenic® program of the Pastoral Genomics Research Consortium in New Zealand, where ryegrass may be improved using only ryegrass genetic elements, using our high-throughput Agrobacterium tumefaciens-mediated genetic transformation platform (Bajaj et al., 2006). We have also serendipitously identified a gene that improves the seed yield (but not the biomass of the plant) in rice by almost two fold. We will present the salient findings from our research in the presentation.
ChemInform Abstract: Formal Total Synthesis of Aglaiastatin: Pd(0)‐Mediated Construction of Benzofurocyclopentane System. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Apparatus for trapping and thermal detection of atomic hydrogen in high magnetic fields at low temperatures (1980)

An apparatus is described in which hydrogen atoms were trapped at temperatures down to 1.1 K in the 11 T field of a large volume superconducting magnet. A high sensitivity thermal detector was used to study trapping and recombination of atoms on the detector surface. The apparatus permits the application of extremely high steady state magnetic fields to study the potential effects of electron spin polarization on the stabilization of hydrogen atoms.
Temperature dependence of physical constants in binary-fluorinated liquid crystal mixtures (2009)

The temperature dependence of dielectric constants and splay elastic constants for fluorinated phenyl bicyclohexane (PBC) binary liquid crystal (LC) mixtures is reported. The results show that the proportions of the constituent elements of binary mixtures strongly influence their anisotropic dielectric constants. For mixtures in which meta-para- and ortho-para-fluorine-substituted molecules are in equal proportion, the effectiveness of the anisotropic dielectric is equal to that with a single para-fluorine- substituted compound. The proportions of a mixture seldom affect the threshold voltage and splay elastic constants in an anti-parallel measurement cell.
A Short and Convenient Preparation of (E)-3-(1-Cyclohexenyl)-2-Propenoic Acid Using a Palladium(II) Complex-Catalyzed Olefination (1999)

Abstract A convenient, three-step preparation of (E)-3-(l-cyclohexenyl)-2-propenoic acid (1) from cyciohexanone was developed, which exploited the palladium(II) complex-catalyzed olefrnation of the triflate 3 as a key step.
Nylon Intermediates from Bio‐Based Levulinic Acid (2019)

Abstract Use of ZrO 2 /SiO 2 as a solid acid catalyst in the ring‐opening of biobased γ‐valerolactone with methanol in the gas phase leads to mixtures of methyl 2‐, 3‐, and 4‐pentenoate (MP) in over 95 % selectivity, containing a surprising 81 % of M4P. This process allows the application of a selective hydroformylation to this mixture to convert M4P into methyl 5‐formyl‐valerate (M5FV) with 90 % selectivity. The other isomers remain unreacted. Reductive amination of M5FV and ring‐closure to ϵ ‐caprolactam in excellent yield had been reported before. The remaining mixture of 2‐ and 3‐MP was subjected to an isomerising methoxycarbonylation to dimethyl adipate in 91 % yield.
Synthesis of a 56 Component Library of Sugar &#946;-Peptides (2002)

Many biological processes of vital importance are triggered by the molecular recognition of small carbohydrate units by proteins and receptors thus leading to the belief that carbohydrates could act as candidates for the design of new drugs. We have developed a new useful synthetic approach, which can be applied in a combinatorial manner, giving access to 1,1-di-substituted pyrans projecting amide side chains in both the alpha- and beta-directions. Thus, treatment of the readily accessible hemiketal (1) with TFA followed by trimethylsilyl trifluoromethanesulfonate (TMSOTf) in the presence of a nitrile gives dihydrooxazinones (2) via a new type of modified intramolecular Ritter reaction. The dihydrooxazinones (2) can either be isolated or used directly in reactions with a broad variety of amines. Final deprotection furnishes the 1,1-di-substituted sugar beta-peptides having the general structure (4).
A note on perfect multiple coverings of the Hamming space (1991)

Let Q be an alphabet of size q>or=2. The Hamming space Q/sup n/ that consists of all n-tuples of elements of Q is a metric space, provided with the Hamming distance function. A perfect multiple covering (PMC) is a code C in Q/sup n/ such that there exist fixed numbers r and mu with the property that every word in Q/sup n/ is within distance r from exactly mu codewords of C. The authors give a few constructions of PMCs and investigate in detail the problem of determining all possible parameters of PMCs with r=1.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
An efficient methodology to evaluate BEOL and MOL TDDB in advanced nodes (2021)

Back-end-of line (BEOL) and Middle-of-line (MOL) time-dependent dielectric breakdown (TDDB) lifetime extrapolations are significantly impacted by process variations as the dielectric processing becomes increasingly complex on advanced technology nodes. In order to evaluate the true intrinsic reliability behavior, the impact of process variations needs to be decoupled. Process variations, when overlooked, can cause sampling artefacts which can affect extrapolated lifetime up to 5 orders of magnitude. We propose an efficient yet straightforward method to decouple die-to-die variations from the intrinsic TDDB behavior. The proposed method helps determine TDDB lifetimes without needing extensive measurements. The methodology is demonstrated for both BEOL and MOL TDDB lifetime extrapolations.