1643 COMPARITIVE STUDY OF BIOCHEMICAL EFFECT OF SALVAGE RADIOTHERAPY AND SALVAGE ANDROGEN DEPRIVATION THERAPY AFTER RADICAL PROSTATECTOMY (2011)

You have accessJournal of UrologyProstate Cancer: Localized1 Apr 20111643 COMPARITIVE STUDY OF BIOCHEMICAL EFFECT OF SALVAGE RADIOTHERAPY AND SALVAGE ANDROGEN DEPRIVATION THERAPY AFTER RADICAL PROSTATECTOMY Seok Hyun Chung, Yunbyung Chae, Ho Song Yu, Kang Su Cho, Won Sik Ham, Woo Jin Bang, Hyun Ho Han, Yong Bae Kim, Ki Chang Keum, and Young Deuk Choi Seok Hyun ChungSeok Hyun Chung Seoul, Korea, Republic of More articles by this author , Yunbyung ChaeYunbyung Chae Seoul, Korea, Republic of More articles by this author , Ho Song YuHo Song Yu Seoul, Korea, Republic of More articles by this author , Kang Su ChoKang Su Cho Seoul, Korea, Republic of More articles by this author , Won Sik HamWon Sik Ham Seoul, Korea, Republic of More articles by this author , Woo Jin BangWoo Jin Bang Seoul, Korea, Republic of More articles by this author , Hyun Ho HanHyun Ho Han Seoul, Korea, Republic of More articles by this author , Yong Bae KimYong Bae Kim Seoul, Korea, Republic of More articles by this author , Ki Chang KeumKi Chang Keum Seoul, Korea, Republic of More articles by this author , and Young Deuk ChoiYoung Deuk Choi Seoul, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1752AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES There are few studies on the effect of salvage radiotherapy (SRtx) and salvage androgen deprivation therapy (SADT) in biochemical recurrence after prostatectomy. To compare the effect of SRtx and SADT on biochemical recurrence rates, we evaluated the oncological outcomes of the two groups. METHODS Two hundred eighty five patients with biochemical recurrence after prostatectomy from May 1998 to March 2009 were included in this study. Patients with lymph node invasion and distant metastasis were excluded. One hundred nine patients underwent SRtx and 176 patients had SADT. Two consecutive PSA increase above 0.2ng/mL was regarded as biochemical recurrence after prostatectomy according to European Association of Urology (EAU). The second biochemical recurrence was defined according to the American Society Therapeutic Radiology and Oncology (ASTRO) criteria as 3 consecutive increase in PSA or 1 elevation high enough to begin salvage therapy. All salvage therapy was administered within 6 months of biochemical recurrence. RESULTS Median follow-up from biochemical recurrence was 50 months (range, 3–149). The margin positive rates, extracapsular extension rates, seminal vesicle invasion rates were not significantly different between the two groups before salvage therapy (p>0.05). Compared with the SADT group, SRtx group had less biochemical recurrence and increased biochemical recurrence-free survival (p<0.05). 4-years biochemical recurrence-free survival rates were 68.5% in SRtx group and 54.7% in SADT group (log rank test, p=0.035). In patients with positive margin, extracapsular extension and seminal vesicle invasion, SRtx was associated with a significant increase in biochemical recurrence-free survival. CONCLUSIONS Our results suggest that SRtx may be helpful for prostate cancer patients with biochemical relapse after radical prostatectomy. Thus, we should consider SRtx with other multimodalities for patients at risk of biochemical recurrence. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e659 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Seok Hyun Chung Seoul, Korea, Republic of More articles by this author Yunbyung Chae Seoul, Korea, Republic of More articles by this author Ho Song Yu Seoul, Korea, Republic of More articles by this author Kang Su Cho Seoul, Korea, Republic of More articles by this author Won Sik Ham Seoul, Korea, Republic of More articles by this author Woo Jin Bang Seoul, Korea, Republic of More articles by this author Hyun Ho Han Seoul, Korea, Republic of More articles by this author Yong Bae Kim Seoul, Korea, Republic of More articles by this author Ki Chang Keum Seoul, Korea, Republic of More articles by this author Young Deuk Choi Seoul, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...