gebhart/patrepeval huggingface dataset:
Right ventricular pacemaker lead position is associated with differences in long‐term outcomes and complications (2017)

Abstract Introduction Cardiac pacing from the right ventricular apex is associated with detrimental long‐term effects and nonapical pacing locations may be associated with improved outcomes. There is little data regarding complications with nonapical lead positions. The aim of this study was to assess long‐term outcomes and lead‐related complications associated with differing ventricular lead tip position. Methods and results All adult patients who underwent dual‐chamber pacemaker implantation from 2004 to 2014 were included if they had postprocedure chest radiographs amenable to lead position determination. Long‐term outcomes and lead‐related complication rates were recorded. These were compared at 5 years between: (1) apical and septal leads, (2) apical and nonseptal nonapical (NSNA), and (3) apical and septal with &gt;40% ventricular pacing. We retrospectively evaluated 3,450 patients, which included 238 with a septal position and 733 with NSNA lead positions. Septal lead position was associated with a lower mortality compared to apical leads (24% vs. 31%, P = 0.02). In patients with greater than 40% pacing, septal leads were associated with significantly higher rates of incident atrial fibrillation compared to apical leads (49% vs. 34%, P = 0.04). NSNA positions were associated with a significantly higher rate of lead dislodgement (4% vs. 2%, P = 0.005) and need for revision (8% vs. 5%, P = 0.005). Conclusions Septal pacemaker lead position is associated with a lower mortality compared to apically placed leads, but a higher incidence of atrial fibrillation with higher percentage ventricular pacing. NSNA lead locations are associated with more complications and should be avoided.
Broadband waveguide QED system on a chip (2009)

We demonstrate that a slot waveguide provides a broadband loss-free platform suitable for applications in quantum optics. We find that strong coupling between light quanta and a single quantum emitter placed in the waveguide slot can be achieved with efficiency higher than 96% and Purcell factor (spontaneous emission factor) larger than 200. The proposed system is a promising platform for quantum information processing and can be used to realize an efficient single photon source and optically addressable photon register.
Controlled-Release Dosage Form (2016)

This Glossary of Terms Related to Pharmaceutics is needed by practitioners in the field of pharmaceutics as this field fulfills an important and crucial role, different from the roles of other scientific disciplines involved in the drugmaking process. The glossary contains 168 definitions used in pharmaceutics. These are related to various aspects of this discipline, such as: (1) physicochemical characterization of pharmaceutical preparations and the active ingredients they contain; (2) unit operations used in the practice of pharmaceutics; (3) terms related to the various dosage forms; (4) terms related to the various modes and routes of drug delivery; (5) terms used in pharmacokinetics and biopharmaceutics in general; and additional miscellaneous terms. The field of pharmaceutics itself is of a multidisciplinary nature as its practitioners come from a variety of disciplines, such as chemistry or various biological sciences, thus a glossary containing authoritative definitions would be useful for them. The terms used in pharmaceutics are rarely covered by existing glossaries, and in the cases they are, their definitions are often inappropriate for the field of pharmaceutics and require new or modified definitions to better fit the new context.
Control channel design for high speed downlink shared channel for 3GPP W-CDMA, Rel-5 (2004)

In 3GPP W-CDMA, high speed downlink packet access functionality is implemented using the high speed downlink shared channel (HS-DSCH) and its associated control channels. In this paper, we describe the overall structure of HS-DSCH and its control channels: the high speed shaped control channel (HS-SCCH) and the high speed uplink DPCCH (HS-DPCCH). We then present detailed link and system simulation results supporting the control channel design. In addition, a new power control method to support HS-DPCCH operation during soft-handoff is described. The proposed algorithm automatically adjusts the power ratio between the control and data channels based on propagation conditions and outperform the conventional scheme with minimum impact to the DPDCH performance.
Capacitive Power Transfer Through a Conformal Bumper for Electric Vehicle Charging (2015)

Wireless power transfer (WPT) is emerging as a practical means for electric vehicle (EV) charging. Of the most common approaches to WPT, inductive coupling, and capacitive coupling, capacitive power transfer (CPT) is proposed to charge an EV at a kilowatt scale power level. CPT implementation replaces copper coils and permeable focusing/shielding materials of inductive approaches with foil surfaces, making CPT a cost effective and structurally simple system to implement while maintaining efficient power transfer capability. This paper addresses the primary technical hurdles to kilowatt scale CPT system development, namely, safe field confinement by achieving high coupling capacitance between the vehicle and the charging station. High capacitive coupling is achieved through a conformal (flexible and compressive) transmitter bumper that molds and contours itself to the vehicle. This minimizes the air gap and confines the field during charging. Here, a conformal surface demonstrates 3-5 times more coupling capacitance than its rigid counterpart of equal area. The associated power electronics are also discussed in detail, utilizing a Class E <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> amplifier/rectifier. An experimental docking station was built to charge the 156 V battery pack of a Corbin Sparrow EV and measured throughput power is demonstrated at 1 kW at ~90% efficiency via a coupling capacitance of 10 nF operating at 530 kHz.
ChemInform Abstract: A CONVENIENT SYNTHESIS OF ETHYL α‐CARBETHOXY‐β‐(ARYLAMINO)ACRYLATES AND RELATED COMPOUNDS (1983)

Abstract Die Herstellung der im Titel genannten Verbindungen (IV) erfolgt durch Umsetzung von aromatischen Aminen (I) und Orthoameisensäureester (II) mit methylenaktiven Verbindungen (III) in Gegenwart von ZnCl 2 .
Exploiting POSS–Sorbitol Interactions: Issues of Reinforcement of Isotactic Polypropylene Spun Fibers (2012)

This study investigates the issues involving reinforcement of isotactic polypropylene (iPP) spun fibers by molecular adducts originating from the synergistic interactions of polyhedral oligomeric silsesquioxane (POSS) containing silanol functionalities (silanol–POSS) and di(benzylidene)sorbitol (DBS). The molecular adducts of silanol–POSS and DBS were low viscosity liquids at fiber spinning temperature, turned into cylindrical domains during fiber spinning, and remained as nanoparticles in the fibers. The fibers were analyzed by differential scanning calorimetry, wide-angle X-ray diffraction , scanning electron microscopy, and transmission electron microscopy. It was observed that iPP compounds with 2–5 wt % silanol–POSS and 1 wt % DBS could be spun into fibers with close to 40% reduction in diameter compared to unfilled iPP. These fibers offered 60–80% increase in tensile modulus, 50–60% increase in tensile strength, and 100% increase in yield strength compared to unfilled iPP. The silanol–POSS particles were found to be of cylindrical shape with approximately 100 nm in diameter and 200–300 nm in length. The improvements in mechanical properties were correlated with iPP crystallinity and orientation factor.
Development of an All Silicon Integrated Optical Modulator for High Speed Data Communications and Sensor Applications (1990)

Abstract : The first generation silicon light intensity modulator had a modulation depth of up to 30% in a bandwidth up to 200 MHz in accordance with the intents of the project, the modulator occupied a small surface area and is fabricated using standard silicon technology, making the modulator suitable for integration with silicon integrated circuits. The second generation of the modulator had several refinements, among which the push-pull design proved to be the most worth while, giving a doubling of the modulation depth. In the design of the modulator special emphasis was put on easy interfacing with fiber optics, and it was demonstrated that the modulator could not only simply and inexpensively be directly coupled to single mode optical fibers (pigtailing), but that the direct coupling of the modulators was more effective and led to a higher modulation index (24%) and lower insertion loss (5dB) even without a anti reflection coating. During the course of the project related areas of interest in device research has been discovered. Among these, electro-optic polymers for high speed modulators and integrated circuit probes have received the most attention so far. A new guest/host system of purely commercially available chemicals had been developed and basic material characteristics in the 1 to 100 GHz are being measured. A more recent research effort that has come out of this project is the investigation of the use of the plasma effect in semiconductors for mode locking of solid state lasers.
Increased hot-carrier effects using SiGe layers in vertical surrounding-gate MOSFETs (2001)

The use of silicon germanium (SiGe) heterostructures in vertical surrounding gate MOSFETs provides an additional means for tailoring current-voltage (I-V) characteristics by controlling physical effects inside the device. Incorporation of an SiGe layer in the vertical MOSFET drain can modify hot-carrier characteristics via material dependent impact ionization coefficients. MOSFETs with ramped SiGe drain layers showed increased drain current in the soft breakdown regime, due to increased impact ionization as verified by substrate current measurement, with up to 1.5 V decreases in breakdown voltage. Comparison of simulation to experiment displayed the difficulties of accurately predicting device parameters, but demonstrated the usefulness of simulation to qualitatively predict device behavior without costly expenditures of time, material, and equipment.
Compact illumination optic with three freeform surfaces for improved beam control (2017)

Multi-chip and large size LEDs dominate the lighting market in developed countries these days. Nevertheless, a general optical design method to create prescribed intensity patterns for this type of extended sources does not exist. We present a design strategy in which the source and the target pattern are described by means of "edge wavefronts" of the system. The goal is then finding an optic coupling these wavefronts, which in the current work is a monolithic part comprising up to three freeform surfaces calculated with the simultaneous multiple surface (SMS) method. The resulting optic fully controls, for the first time, three freeform wavefronts, one more than previous SMS designs. Simulations with extended LEDs demonstrate improved intensity tailoring capabilities, confirming the effectiveness of our method and suggesting that enhanced performance features can be achieved by controlling additional wavefronts.
Variations d'origine alimentaire de la motricité digestive chez le lapin (1987)

Etude de la motricite digestive chez le lapin sous differents regimes alimentaires a l'aide de la technique d'electromyographie chronique. Mise en evidence du role respectif des neurones noradrenergiques et serotoninergiques dans les modifications liees a la mouture et a la composition de l'aliment et dans la genese de diarrhees et de paresies calcales
Tunable Assembly of Gold Nanorods in Polymer Solutions To Generate Controlled Nanostructured Materials (2018)

Gold nanorods grafted with short-chain polymers are assembled into controlled open structures using polymer-induced depletion interactions and structurally characterized using small-angle X-ray scattering. When the nanorod diameter is smaller than the radius of gyration of the depletant polymer, the depletion interaction depends solely on the correlation length of the polymer solution and not directly on the polymer molecular weight. As the polymer concentration increases, the stronger depletion interactions increasingly compress the grafted chains and push the gold nanorods closer together. By contrast, other structural characteristics such as the number of nearest neighbors and fractal dimension exhibit a nonmonotonic dependence on polymer concentration. These parameters are maximal at intermediate concentrations, which are attributed to a crossover from reaction-limited to diffusion-limited aggregation. The control over structural properties of anisotropic nanoscale building blocks demonstrated here will be beneficial to designing and producing materials in situ with specific direction-dependent nanoscale properties and provides a crucial route for advances in additive manufacturing.
Constructive and adaptable distributed shared memory (2002)

Distributed shared memory (DSM) is a paradigm for programming distributed systems, which provides an alternative to the message passing model. DSM offers the agents of the system a shared address space through which they can communicate with each other. The main problem of a DSM implementation on top of a message passing system is performance. Performance of an implementation is closely related to the consistency the DSM system offers: strong consistency (all agents agree about how memory events happen) and is more expensive to implement than weak consistency (disagreements are allowed). There have been many DSM systems proposals, each one supporting different consistency levels. Experience has shown that no one is well suited for the whole range of problems. In some cases, strong consistent primitives are not needed, while in other cases, the weak semantics provided are useless. This is also true for different implementations of the same memory model, since performance is also affected by the data access patterns of the applications. We introduce a novel DSM model called Mume. Mume is a low level layer close to the level of the message passing interface. The Mume interface provides only the minimum requirements to be considered as a shared memory system. The interface includes three types of synchronization primitives, namely total ordering, causal ordering and mutual exclusion. This allows efficient implementations of different memory access semantics, accommodating particular data access patterns.
T-helper cell receptors from long-term survivors after telomerase cancer vaccination for use in adoptive cell therapy (2016)

We herein report retargeting of T-helper (Th) cells against the universal cancer antigen telomerase for use in adoptive cell therapy. The redirected Th cells may counter tumor tolerance, transform the inflammatory milieu, and induce epitope spreading and cancer senescence. We have previously conducted a series of trials evaluating vaccination with telomerase peptides. From long-term survivors, we isolated >100 CD4<sup>+</sup> Th-cell clones recognizing telomerase epitopes. The clones were characterized with regard to HLA restriction, functional avidity, fine specificity, proliferative capacity, cytokine profile, and recognition of naturally processed epitopes. DP4 is the most prevalent HLA molecule worldwide. Two DP4-restricted T-cell clones with different functional avidity, C13 and D71, were selected for molecular T-cell receptor (TCR) cloning. Both clones showed a high proliferative capacity, recognition of naturally processed telomerase epitopes, and a polyfunctional and Th1-weighted cytokine profile. TCR C13 and D71 were cloned into the retroviral vector MP71 together with the compact and GMP-applicable marker/suicide gene RQR8. Both TCRs were expressed well in recipient T cells after PBMC transduction. The transduced T cells co-expressed RQR8 and acquired the desired telomerase specificity, with a polyfunctional response including production of TNFa, IFNγ, and CD107a. Interestingly, the DP4-restricted TCRs were expressed and functional both in CD4<sup>+</sup> and CD8<sup>+</sup> T cells. The findings demonstrate that the cloned TCRs confer recipient T cells with the desired hTERT-specificity and functionality. We hypothesize that adoptive therapy with Th cells may offer a powerful novel approach for overcoming tumor tolerance and synergize with other forms of immunotherapy.
Total Synthesis of Pseudotrienic Acid B: A Bioactive Metabolite from Pseudomonas sp. MF 381‐IODS (2006)

Acid advancement: An efficient and highly convergent stereoselective synthesis of pseudotrienic acid B (see structure) has been achieved. Synthetic highlights include a crotyltitanation reaction to control the stereogenic centers at C11 and C20, a cross-metathesis reaction to synthesize the triene moiety, and a Stille cross-coupling reaction to complete the assembly of the carbon framework of the natural product.
Dynamics of Electrocatalytic Oxidation of Ethylene Glycol, Methanol and Formic Acid at MWCNT Platform Electrochemically Modified with Pt/Ru Nanoparticles (2010)

Abstract Comparative electrocatalytic behavior of functionalized multiwalled carbon nanotubes (fMWCNTs) electrodecorated with Pt/Ru nanoparticles towards the oxidation of methanol (MeOH), ethylene glycol (EG) and formic acid (FA) has been investigated. The catalytic current density decreased approximately as MeOH≈EG&gt;FA. Result revealed that BPPGE‐fMWCNT‐Pt/Ru tolerates CO poisoning for FA electrooxidation than when used for the oxidation of the EG or MeOH. Electrochemical impedance spectra are dependent on the oxidation potentials, with equivalent circuit models characteristic of adsorption‐controlled charge transfer kinetics. The results provide important insights into the electrochemical response of these small organic molecules useful in fuel cell technology.
Passive cavity enhancement of a femtosecond fiber chirped pulse amplification system to 204W average power (2007)

An external passive cavity has been used to demonstrate more than 200-times enhancement of a 1-W-average-power Yb chirped mode-locked fiber-laser-system emitting ≈120-fs pulses at 90-MHz repetition-rate. Peak intra-cavity intensities of &gt;1012 W/cm2 were achieved.
Queue aware precoder design for space frequency resource allocation (2014)

The paper considers coordinated multi-cell multi-user multiple-input multiple-output (MU-MIMO) transmission using orthogonal frequency division multiplexing (OFDM) technique for downlink channels. Linear beamforming and receiving are employed at BS and corresponding users, respectively. The design criterion is to minimize the number of queued packets, since the transmission is mainly guided by the backlogged packets. An indirect way to solve this problem is to associate the weights of the traditional weighted sum rate maximization scheme with the current status of the queue size, i.e., the longer queue, the higher priority. We deal with this problem directly by formulating it as a noncovex optimization problem and then applying a sequential convex approximation method to find beamformers. In particular, we propose an efficient resource allocation scheme based on jointly optimizing beamformers over the space and frequency domain. We refer to this scheme as queue minimizing (QM) joint space-frequency resource allocation (JSFRA) scheme. The proposed solutions are compared to the traditional queue weighted sum rate maximization (Q-WSRM) approaches mentioned above in terms of the rate of convergence and the backlogged packets remaining after a scheduling instant.
Anthracyclines and related substances. 3. Regiospecific total synthesis of 11-deoxydaunomycinone (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnthracyclines and related substances. 3. Regiospecific total synthesis of 11-deoxydaunomycinoneS. David Kimball, David R. Walt, and Francis JohnsonCite this: J. Am. Chem. Soc. 1981, 103, 6, 1561–1563Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/ja00396a047https://doi.org/10.1021/ja00396a047research-articleACS PublicationsRequest reuse permissionsArticle Views227Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts