gebhart/patrepeval huggingface dataset:
Human Endogenous Retrovirus K106 (HERV-K106) Was Infectious after the Emergence of Anatomically Modern Humans (2011)

HERV-K113 and HERV-K115 have been considered to be among the youngest HERVs because they are the only known full-length proviruses that are insertionally polymorphic and maintain the open reading frames of their coding genes. However, recent data suggest that HERV-K113 is at least 800,000 years old, and HERV-K115 even older. A systematic study of HERV-K HML2 members to identify HERVs that may have infected the human genome in the more recent evolutionary past is lacking. Therefore, we sought to determine how recently HERVs were exogenous and infectious by examining sequence variation in the long terminal repeat (LTR) regions of all full-length HERV-K loci. We used the traditional method of inter-LTR comparison to analyze all full length HERV-Ks and determined that two insertions, HERV-K106 and HERV-K116 have no differences between their 5' and 3' LTR sequences, suggesting that these insertions were endogenized in the recent evolutionary past. Among these insertions with no sequence differences between their LTR regions, HERV-K106 had the most intact viral sequence structure. Coalescent analysis of HERV-K106 3' LTR sequences representing 51 ethnically diverse individuals suggests that HERV-K106 integrated into the human germ line approximately 150,000 years ago, after the emergence of anatomically modern humans.
Globo H Is a Promising Theranostic Marker for Intrahepatic Cholangiocarcinoma (2021)

Recent studies support the development of cancer therapeutics to target Globo H-ceramide, the most prevalent tumor-associated carbohydrate antigen in epithelial cancers. Herein, we evaluated the expression of Globo H and its prognostic significance in intrahepatic cholangiocarcinoma (ICC) and conducted preclinical studies to assess the antitumor activity of Globo H-specific antibody in thioacetamide (TAA)-induced ICC in rats. Globo H-ceramide in tumor specimens was detected by immunohistochemistry (IHC) and mass spectrometry. Antitumor efficacy of anti-Globo H mAbVK9 was evaluated in TAA-induced ICC in rat. Natural killer (NK) cells and their related genes were analyzed by IHC and quantitative real-time polymerase chain reaction. Data mining revealed that B3GALT5 and FUT2, the key enzymes for Globo H biosynthesis, were significantly up-regulated in human ICC. In addition, Globo H expression was detected in 41% (63 of 155) of ICC tumor specimens by IHC staining, and validated by mass spectrometric analysis of two IHC-positive tumors. Patients with Globo H positive tumors had significantly shorter relapse-free survival (RFS) and overall survival (P = 0.0003 and P = 0.002, respectively). Multivariable Cox regression analysis identified Globo H expression as an independent unfavorable predictor for RFS (hazard ratio: 1.66, 95% confidence interval: 1.08-2.36, P = 0.02) in ICC. Furthermore, gradual emergence of Globo H in liver tissues over 6 months in TAA-treated rats recapitulated the multistage progression of ICC in vivo. Importantly, administration of anti-Globo H mAbVK9 in rats bearing TAA-induced ICC significantly suppressed tumor growth with increased NK cells in the tumor microenvironment. Conclusion: Globo H is a theranostic marker in ICC.
Best-Effort Top-k Query Processing Under Budgetary Constraints (2009)

We consider a novel problem of top-k query processing under budget constraints. We provide both a framework and a set of algorithms to address this problem. Existing algorithms for top-k processing are budget-oblivious, i.e., they do not take budget constraints into account when making scheduling decisions, but focus on the performance to compute the final top-k results. Under budget constraints, these algorithms therefore often return results that are a lot worse than the results that can be achieved with a clever, budget-aware scheduling algorithm. This paper introduces novel algorithms for budget-aware top-k processing that produce results that have a significantly higher quality than those of state-of-the-art budget-oblivious solutions.
Development of Gut-Selective Pan-Janus Kinase Inhibitor TD-1473 for Ulcerative Colitis: A Translational Medicine Programme (2020)

Gut-selective pan-JAK inhibition with TD-1473 administration resulted in high intestinal vs plasma drug exposure, local target engagement, and trends toward reduced UC disease activity. [Clinicaltrials.gov NCT02657122, NCT02818686].
Automatic transliteration for Japanese-to-English text retrieval (2003)

For cross language information retrieval (CLIR) based on bilingual translation dictionaries, good performance depends upon lexical coverage in the dictionary. This is especially true for languages possessing few inter-language cognates, such as between Japanese and English. In this paper, we describe a method for automatically creating and validating candidate Japanese transliterated terms of English words. A phonetic English dictionary and a set of probabilistic mapping rules are used for automatically generating transliteration candidates. A monolingual Japanese corpus is then used for automatically validating the transliterated terms. We evaluate the usage of the extracted English-Japanese transliteration pairs with Japanese to English retrieval experiments over the CLEF bilingual test collections. The use of our automatically derived extension to a bilingual translation dictionary improves average precision, both before and after pseudo-relevance feedback, with gains ranging from 2.5% to 64.8%.
Signal Analysis, Synthesis and Processing Using Fractals and Wavelets. (1995)

Abstract : The research performed under this grant is summarized. In one component of the research, robust algorithms for signal processing with fractal signals were developed using wavelet based representations. In a second component of the research, algorithms for addressing problems of detection, estimation and modeling using nonlinear and chaotic signals were developed. Finally, in a third component of the research, efficient algorithms for signal enhancement and active noise cancellation were developed. The resulting algorithms are promising candidates for a host of defense and related applications.
Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects (2021)

Curcumin is a phytochemical isolated from Curcuma longa with potent tumor-suppressor activity, which has shown significant efficacy in pre-clinical and clinical studies. Curcumin stimulates cell death, triggers cycle arrest, and suppresses oncogenic pathways, thereby suppressing cancer progression. Cisplatin (CP) stimulates DNA damage and apoptosis in cancer chemotherapy. However, CP has adverse effects on several organs of the body, and drug resistance is frequently observed. The purpose of the present review is to show the function of curcumin in decreasing CP's adverse impacts and improving its antitumor activity. Curcumin administration reduces ROS levels to prevent apoptosis in normal cells. Furthermore, curcumin can inhibit inflammation via down-regulation of NF-κB to maintain the normal function of organs. Curcumin and its nanoformulations can reduce the hepatoxicity, neurotoxicity, renal toxicity, ototoxicity, and cardiotoxicity caused by CP. Notably, curcumin potentiates CP cytotoxicity via mediating cell death and cycle arrest. Besides, curcumin suppresses the STAT3 and NF-ĸB as tumor-promoting pathways, to enhance CP sensitivity and prevent drug resistance. The targeted delivery of curcumin and CP to tumor cells can be mediated nanostructures. In addition, curcumin derivatives are also able to reduce CP-mediated side effects, and increase CP cytotoxicity against various cancer types.
Some Results on Implementing Low-Complex ICI Cancellation for DVB-H (2007)

A combination of receiver windowing and inter-carrier interference (ICI) canceling is proposed for improving the Doppler frequency performance of a DVB-H receiver. The windowing reduces the ICI, and enables ICI cancellation of low complexity to give substantial improvements. Bounds for the possible improvements of ICI cancellation are presented and compared to results from both simulations and measurements on a DVB-H prototype. The obtained improvements from windowing agree well with that predicted by theory, whereas the gain from ICI cancellation is considerably smaller. This is primarily due to non-ideal channel estimation, which also is discussed. Although the measured performance for ICI cancellation is far from that theoretically possible, the gain in what Doppler frequency can be handled is more than 40%.
Papers Presented at the Hip Society Meetings 2008: Editorial Comment (2008)

The 2008 symposium of Proceedings of the Hip Society provides a wide-ranging mixture of issues relevant to hip surgery. These manuscripts represent topics presented and discussed at the 2007 Annual Closed Fall Meeting held in Pasadena, California and the 2008 Open Scientific Winter Meeting in San Francisco, California as organized by Lawrence D. Dorr, MD and myself. The classic paper by Merle d'Aubigné is a particularly interesting manuscript that is a very enjoyable study and should be read by all surgeons currently involved with hip arthroplasty. Readers might not be aware Merle d'Aubigné and his colleagues proposed not one, but three scoring systems: one in English and two in French. These differences are explained in the accompanying biosketch. As might be expected, new topics this year included papers on computer navigation systems for the hip and reports on the resurgence of hip resurfacing. In particular, the resurfacing papers focus on the importance of patient selection, surgical technique, and revision of failed resurfacing procedures. Several manuscripts related to long-term followup of cementless femoral components provide the baseline of performance expected with modern hip arthroplasty as we receive more information on the outcomes of resurfacing. The remainder of the symposium focuses on a large variety of topics related to surgical techniques and prosthetic design to optimize component position and avoid prosthetic impingement and optimal fixation. Additional topics included wear analysis with ceramic on crosslinked polyethylene, the presence of metal ions following metal-on-metal hip replacement, and the assessment of osteolysis by computed tomography. There were many papers on acetabular and femoral failures which included a previously unreported failure mode related to the use of lateralized acetabular liners. Acetabular revision techniques for isolated acetabular polyethylene exchange and the treatment of large acetabular bone defects and treatment of severe femoral bone loss are included. A paper on why revision hip arthroplasties fail yet again is particularly interesting. Finally, a group of papers describing perioperative complications of early mortality, deep periprosthetic infection, and treatment of periprosthetic femoral fractures completes the broad spectrum of topics for readers of this year's symposium.
Correction: Correlation of Memory T Cell Responses against TRAP with Protection from Clinical Malaria, and CD4+CD25highT Cells with Susceptibility in Kenyans (2011)

Background: Immunity to malaria develops naturally in endemic regions, but the protective immune mechanisms are poorly understood. Many vaccination strategies aim to induce T cells against diverse pre-erythrocytic antigens, but correlates of protection in the field have been limited. The objective of this study was to investigate cell-mediated immune correlates of protection in natural malaria. Memory T cells reactive against thrombospondin-related adhesive protein (TRAP) and circumsporozoite (CS) protein, major vaccine candidate antigens, were measured, as were frequencies of CD4 + CD25 high T cells, which may suppress immunity, and CD56 + NK cells and cd T cells, which may be effectors or may modulate immunity.
DAMAGE TO CEILINGS OF SCHOOL BUILDINGS DUE TO THE 2011 TOHOKU EARTHQUAKE AND AFTERSHOCKS (2015)

In order to clarify the damage to ceilings as nonstructural element on school buildings due to the 2011 Tohoku Earthquake, total 205 school buildings were investigated according to documents for disaster restoration work. Damages to ceilings are concentrated on the top floor of the buildings. Bend-form ceilings tend to be damaged more than flat ones. Falls of ceiling with furrings are approximately 40% of total falls. There are many damaged ceilings even the building have enough seismic strength for current standard.
Implementation and evaluation of Google Glass for visualizing real-time image and patient data in the primary care office (2014)

Primary care physicians must conduct a staggering number of comprehensive physical exams and medical record reviews, resulting in demanding daily schedules. Few commercial technologies have been marketed towards the primary care market, which has stifled improvements in disease screening and detection, work flow, and records management, taking time away from interactions with patients. In efforts to improve the quality of care in primary care medicine, we integrated our handheld primary care optical imaging system with Google Glass©, a commercial heads-up display (HUD). The integration of a HUD allows the physician to focus on the patient during the medical history review and during the patient exam, resulting in potential improvements to the quality of care and efficient access to real-time data for display and analysis.
Fractal microwave filters (2010)

In order to meet the ever increasing demand for miniaturization of RF and microwave filters, the suitability of fractal resonators has been examined and a complete design method of miniaturized fractal filters has been developed. It is shown that fractal resonators can significantly be smaller than conventional planar resonators for the same resonant frequency requirements. It is also seen that when increasing the number of fractal iterations, the size of the resonators decreases and the quality factor increases. The design method for miniaturized fractal filters is based on the synthesis of an inline prototype with symmetrical or asymmetrical pseudo-elliptic characteristics and coupling factor simulations using a commercial electromagnetic simulator. Several fractal filters were designed and built using suspended substrate technology. The fabrication was done in house and with the help of a general purpose printed circuit board company. Judging from the quality of the measured filter responses, the fabrication of fractal filters should not be an issue.
Human Variation and Lexical Choice (2002)

Much natural language processing research implicitly assumes that word meanings are fixed in a language community, but in fact there is good evidence that different people probably associate slightly different meanings with words. We summarize some evidence for this claim from the literature and from an ongoing research project, and discuss its implications for natural language generation, especially for lexical choice, that is, choosing appropriate words for a generated text.
Synthesis and Nonlinear Optical Characterization of Spin-Coated Films of Triblock Copolymers Containing Durham Polyacetylene (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Nonlinear Optical Characterization of Spin-Coated Films of Triblock Copolymers Containing Durham PolyacetyleneG. S. W. Craig, R. E. Cohen, R. R. Schrock, A. Esser, and W. SchrofCite this: Macromolecules 1995, 28, 7, 2512–2518Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/ma00111a053https://doi.org/10.1021/ma00111a053research-articleACS PublicationsRequest reuse permissionsArticle Views143Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
K-ras oncogene activation in atypical alveolar hyperplasias of the human lung. (1996)

Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise and may be a good target for studying the early events of lung tumorigenesis. A common genetic alteration in lung adenocarcinomas is mutational activation of K-ras. To determine the timing of K-ras activation, we evaluated formalin-fixed and paraffin-embedded tissue samples of 41 AAHs and their paired lung neoplasms from 28 patients for codon 12 point mutations of the K-ras oncogene. K-ras codon 12 mutations were detected using PCR followed by allele-specific oligonucleotide hybridization. Mutations were found in 16 (39%) of the 41 AAHs, 8 (42%) of the 18 adenocarcinomas, and none (0%) of the 5 lung neoplasms that were not adenocarcinomas. Of the 18 patients with both an AAH and a synchronous lung adenocarcinoma, 6 had K-ras mutation in the adenocarcinoma but not in the AAH, 6 had mutations in the AAH but not in the adenocarcinoma, 4 did not harbor mutations in either the AAH or the adenocarcinoma, and 2 had mutations in both their AAH and their synchronous adenocarcinoma. In just 1 of the 18 patients was the same K-ras mutation present in the AAHs and adenocarcinoma of the patient. The detection of independent activating point mutations in a cancer-causing gene points to the neoplastic nature of AAH and suggests that glandular neoplasms of the lung arise from a background of field cancerization.
Maximum Production and Safe Injection Through Cruise Control of Producers and Injectors (2017)

Abstract Process disturbances may cause reduction in production as the necessary margins to process constraints need to take peak values into account. If the process disturbances can be suppressed, it is possible to operate closer to constraints resulting in higher production. For both injection and production wells, process disturbance rejection is typically achieved with automatic choke control, which is also beneficial for efficiently achieving changing target values. Good control requires accurate and up-to-date measurements. For cases where no reliable physical sensor is available, robust soft sensor design is a key element in the well control solution. The process disturbances caused by natural fluctuations of the underlying process require frequent adjustments of the well chokes to maintain key parameters at their desired values. If wells are choked to ensure operation within given constraints, it is normally beneficial to implement automatic choke control since this enables operation closer to these constraints. The control target may also be to track a calculated downhole pressure trajectory during well restart. A smooth restart is important for some wells to avoid excessive sand production. In addition, automatic actions can be taken to reduce the risk of safety issues. This paper presents field experience as perceived by a control engineer from applying automatic choke control to a large number of water injectors to stabilize the downhole injection pressure or injection rate and application of automatic control for production chokes to control downhole pressure. During restarts of production wells, the downhole pressure follows a pressure trajectory set point to minimize pressure fluctuations to avoid excessive sand production. Exchanging manual infrequent choke manipulations with automatic control to keep the process close to the true, physical constraints, enables safe and optimal production.
On-Chip Mode Conversion with MEMS-Tunable Phase-Matching (2022)

We demonstrate on-chip mode conversion using micro-electro-mechanical systems to tune the phase-matching condition in an asymmetrical directional coupler. Simulations confirm broadband mode conversion consistent with tunable phase-matching. Measurements demonstrate tunable TE 0 -TE 2 to TE 0 -TE 1 conversion.
Integral micro-channel liquid cooling for power electronics (2010)

A novel integral micro-channel heat sink was developed, featuring an array of sub-millimeter channels fabricated directly in the back-metallization layer of the direct bond copper or active metal braze ceramic substrate, thus minimizing the material between the semiconductor junction and fluid and the overall junction-to-fluid thermal resistance. The ceramic substrate is bonded to a baseplate that includes a set of interleaved inlet and outlet manifolds for uniform fluid distribution across the actively cooled area of the heat sink. The interleaved manifolds greatly reduce the pressure drop and minimize temperature gradient across the heat sink surface. After performing detailed simulations and design optimization, a 200 A, 1200 V IGBT power module with the integral heat sink was fabricated and tested. The junction-to-fluid thermal resistivities for the IGBTs and diodes were 0.17°C*cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /W and 0.14°C*cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /W, respectively. The design is superior to all reported liquid cooled heat sinks with a comparable material system, including the micro-channel designs. It is also easily scaleable to larger heat sink surfaces without compromising the performance.
A 90 mW 4 Gb/s equalized I/O circuit with input offset cancellation (2002)

Recently-described CMOS serial links operate at multiple gigabits/s signaling rates over several meters of cable. However, these previous links require large amounts of power and chip area, making them unsuitable for applications requiring hundreds of I/Os per chip. The best previously-published power and area above 4 Gb/s in CMOS are 310 mW and 0.6 mm/sup 2/. Integration of a hundred of these I/Os would burn more than 30 W of power and consume 60 mm/sup 2/ of chip area. The 4 Gb/s transceiver described here dissipates only 90 mW and requires less than 0.1 mm/sup 2/ chip area. This transceiver achieves low-power and low area using an input-multiplexed transmitter architecture, a regulated CMOS inverter-based delay-locked loop (DLL), and receiver offset calibration.
An improved IPNLMS algorithm for echo cancellation in packet-switched networks (2004)

We present an improved adaptive echo cancellation algorithm designed for use with sparse echo path impulse responses such as arise from packet-switched networks. The new approach implicitly segments the impulse response into 'active' and 'inactive' regions, and employs different proportionate updating in each region. An efficient partial updating scheme is then formulated for the new algorithm. Evaluation results are presented to compare the new algorithm against three existing methods in terms of convergence and computational complexity. The results show that the new algorithm outperforms the best existing technique and has lower complexity.