gebhart/patrepeval huggingface dataset:
MP53-01 DEFINING DELIVERABLES OF MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING (MPMRI)/ULTRASOUND (US) FUSION-GUIDED TARGETED PROSTATE BIOPSY: ACTIONABLE INTELLIGENCE METRIC (AIM) AND REDUCTION METRIC (RM) (2016)

INTRODUCTION AND OBJECTIVES: Transrectal ultrasoundguided prostate biopsy (TRUS-B) is the gold standard for prostate cancer (CaP) diagnosis. mpMRI/US fusion targeted biopsy (TB) has emerged as a technique to optimize the procedure. The ideal prostate biopsy would: (1) identify all non-low risk CaP with greater sensitivity than TRUS-B; (2) eliminate the need for unnecessary sampling. Using our institutional dataset and the available literature, the objective of the present study was to define metrics that more accurately demonstrate the deliverables of TB and facilitate meaningful data comparisons.
Preparation of Continuous Highly Hydrophobic Pure Silica ITQ-29 Zeolite Layers on Alumina Supports (2020)

The preparation of continuous layers of highly hydrophobic pure silica ITQ-29 zeolite, potentially applicable as hydrophobic membranes for separation of molecules based on their polarity, has been investigated. Continuous layers of intergrown ITQ-29 zeolite crystals were successfully grown on porous alumina supports by optimization of the synthesis conditions, such as the appropriate selection of the seeds, the procedure for the gel preparation, and the calcination conditions. This resulted in the formation of all silica ITQ-29 zeolite layers without the presence of germanium required in previously reported ITQ-29 membranes, with the subsequent improvement in quality and stability, as verified by the absence of cracks after calcination. We have proved that the incorporation of aluminum from the support into the zeolite layer does not occur, neither during the secondary growth nor through migration of aluminum species during calcination.
Optimization of Click Chemistry Using Azide and Alkyne Scavenger Resins (2007)

Abstract The copper catalyzed [3+2]‐cycloaddition of azides and alkynes has attracted enormous attention due to its striking suitability for the construction of bioconjugates, polymers, and bioactive small molecules. We herein present new, readily approachable polymer‐supported scavenger resins allowing an efficient and high yielding parallel synthesis of 1,4‐substituted 1,2,3‐triazoles. Azidomethyl‐substituted polystyrene 1 and the alkynoylamino functionalized resin 3 proved to quantitatively remove unreacted alkynes and azides, respectively. Model libraries of triazole derivatives could be obtained in high yield and excellent purity suggesting the application of this practical methodology for parallel solution phase chemistry.
Localization and regulation of endothelial NO synthase mRNA expression in rat kidney (1994)

Nitric oxide (NO) has effects on renal blood flow, glomerular filtration rate, renin secretion, and renal sodium excretion. Four isoforms of nitric oxide synthase (NOS) have been cloned to date. However, the molecular identity of NOS present in the renal vasculature is unknown. Endothelial NOS (NOS-III) is regulated both acutely by cell calcium and chronically by shear stress. To determine if renal blood vessels and the glomerulus express NOS-III mRNA, we used degenerate polymerase chain reaction (PCR) to clone a portion of rat NOS-III. We then assayed NOS-III mRNA in microdissected renal structures by reverse transcriptase-PCR. NOS-III mRNA was expressed at high levels in glomeruli, arcuate vessels, and interlobular artery/afferent arterioles. NOS-III mRNA was detected inconsistently in proximal tubules, thick ascending limbs, and cortical and inner medullary collecting ducts. Previous studies have shown that chronic oral treatment with the NOS inhibitor N omega-nitro-L-arginine methyl ester (L-NAME) decreases NO synthesis and causes hypertension. To determine if the systemic blockade occurs only by competitive inhibition, we determined the effect of L-NAME on glomerular NOS-III mRNA. L-NAME administration (5 days) decreased NOS-III mRNA in the glomerulus to 25 +/- 12% of control levels. We conclude that endothelial NOS-III mRNA is preferentially expressed in the glomerulus and renal vasculature, where it can modulate renal blood flow and glomerular filtration rate. Furthermore, glomerular NOS-III may be modulated at the level of mRNA abundance in vivo by systemic L-NAME.(ABSTRACT TRUNCATED AT 250 WORDS)
Troponin I protein kinase C phosphorylation sites and ventricular function (2004)

(1) TG mice exhibit calcium-dependent positive inotropy without slowed relaxation and this phenotype is mitigated by concomitant (compensatory) changes of reduced intracellular Ca2+ and increased phosphorylation of remaining cTnI sites. (2) The contractile phenotype in TG mice can be interpreted as an amplification of the normal response to changes in cellular Ca2+ observed in WT mice. Thus, PKC phosphorylation sites on cTnI play a role in attenuating contractile responses to changes in intracellular Ca2+.
Development and reproduction of Spodoptera eridania (Lepidoptera: Noctuidae) and its egg parasitoid Telenomus remus (Hymenoptera: Platygastridae) on the genetically modified soybean (Bt) MON 87701 × MON 89788 – Corrigendum (2015)

Development and reproduction of Spodoptera eridania (Lepidoptera: Noctuidae) and its egg parasitoid Telenomus remus (Hymenoptera: Platygastridae) on the genetically modified soybean (Bt) MON 87701 × MON 89788 – Corrigendum - Volume 105 Issue 2
Language Model Supervision for Handwriting Recognition Model Adaptation (2018)

Training state-of-the-art offline handwriting recognition (HWR) models requires large labeled datasets, but unfortunately such datasets are not available in all languages and domains due to the high cost of manual labeling.We address this problem by showing how high resource languages can be leveraged to help train models for low resource languages.We propose a transfer learning methodology where we adapt HWR models trained on a source language to a target language that uses the same writing script.This methodology only requires labeled data in the source language, unlabeled data in the target language, and a language model of the target language. The language model is used in a bootstrapping fashion to refine predictions in the target language for use as ground truth in training the model.Using this approach we demonstrate improved transferability among French, English, and Spanish languages using both historical and modern handwriting datasets. In the best case, transferring with the proposed methodology results in character error rates nearly as good as full supervised training.
Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP (2008)

These data suggest that HOP participates in the regulation of the adult mouse hippocampal stem cell niche by negatively affecting cell survival. In addition, HOP may work as a tumor suppressor in a subset of glioblastomas. HOP function thus appears to be critical in the adult brain in a region of continued plasticity, and its deregulation may contribute to disease.
Trends for and Clinical Factors Associated with Choice of Oral P2Y12 Inhibitors for Patients on Chronic Dialysis (2019)

Between 2011 and 2014, clopidogrel remained the most common P2Y12-I whereas ticagrelor and prasugrel remained underutilized in ESRD patients. Prescribing practices for these drugs were based upon clinically approved indication for their use in the general population as well as perceived complexity of an ESRD patient including demographics, dialysis-related factors and comorbidities. Comparative effectiveness studies involving ESRD patients are needed to prove that ticagrelor and prasugrel are just as safe and effective as clopidogrel before clinicians can make informed decisions for choice of P2Y12-I in this patient population.
Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid‐Anchored Peptide Vaccines (2013)

Sensitivity is the key: Dynamic nuclear polarization NMR spectroscopy provides structural information on liposomal vaccines targeting Alzheimer's disease. DMPC/DMPG/Cholesterol mainly stabilizes extended structures of the lipid-anchored peptide, while in DMTAP/Cholesterol liposomes the peptide adopts a multitude of conformations including random-coil and extended structures. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Molecular Analysis of Dehalococcoides 16S Ribosomal DNA from Chloroethene-Contaminated Sites throughout North America and Europe (2002)

The environmental distribution of Dehalococcoides group organisms and their association with chloroethene-contaminated sites were examined. Samples from 24 chloroethene-dechlorinating sites scattered throughout North America and Europe were tested for the presence of members of the Dehalococcoides group by using a PCR assay developed to detect Dehalococcoides 16S rRNA gene (rDNA) sequences. Sequences identified by sequence analysis as sequences of members of the Dehalococcoides group were detected at 21 sites. Full dechlorination of chloroethenes to ethene occurred at these sites. Dehalococcoides sequences were not detected in samples from three sites at which partial dechlorination of chloroethenes occurred, where dechlorination appeared to stop at 1,2-cis-dichloroethene. Phylogenetic analysis of the 16S rDNA amplicons confirmed that Dehalococcoides sequences formed a unique 16S rDNA group. These 16S rDNA sequences were divided into three subgroups based on specific base substitution patterns in variable regions 2 and 6 of the Dehalococcoides 16S rDNA sequence. Analyses also demonstrated that specific base substitution patterns were signature patterns. The specific base substitutions distinguished the three sequence subgroups phylogenetically. These results demonstrated that members of the Dehalococcoides group are widely distributed in nature and can be found in a variety of geological formations and in different climatic zones. Furthermore, the association of these organisms with full dechlorination of chloroethenes suggests that they are promising candidates for engineered bioremediation and may be important contributors to natural attenuation of chloroethenes.
Guest Editorial: Secure Radio-Frequency (RF)-Analog Electronics and Electromagnetics (2022)

No abstract available.
VIPA spectrometer calibration and comb-cavity locking schemes comparison for sensitive and accurate frequency comb spectroscopy (2017)

In direct frequency comb spectroscopy with a VIPA spectrometer, the resolution of the spectrometer is usually insufficient to resolve the comb modes. Thus, one can either filter the modes, reducing the density of spectral elements or cope with the inability to uniquely identify spectral elements with individual comb modes by calibrating the spectrometer itself. Here, we present a way to make use of the inherent frequency accuracy of a stabilized frequency comb to calibrate the spectrometer. We also present a comparison between two commonly used schemes to stabilize the coupling between a frequency comb and cavity resonances: the Pound-Drever-Hall locking scheme and the swept coupling scheme.
Unconventional Reservoir Fracture Evaluation Utilizing Deep Shear-Wave Imaging (2013)

Abstract Unconventional shale reservoir evaluation and development are extremely challenging. One of the most dominating aspects is permeability, which is measured in the nano-darcy range. Although these wells are stimulated to enhance production, the presence or absence of natural fractures can have a large impact on the production results. In addition, the fracture variation across a reservoir can be substantial, leading to large production variations, even in adjacent wells. Gaining insight about the natural fracture system, both intersecting and around the borehole, is crucial and can often help determine the economic success of a well and/or reservoir. The standard means of fracture evaluation, such as borehole imaging, Stoneley permeability analysis, and azimuthal shear-wave anisotropy evaluation from cross-dipole, provide valuable information when evaluating fractures. These standard methods, however, can only investigate a limited area around the borehole—imaging looks at the borehole wall and the other borehole acoustic methods rely on refracted and guided modes that respond to an area as large as 2 to 4 ft out into the formation. The flexural wave from the dipole is one of the guided modes that generally reads the deepest and is used in the standard cross-dipole analysis. In addition to flexural mode, the dipole source creates shear body waves that radiate away from the borehole and into the formation. When these shear waves impinge on a fracture their energy reflects back to the borehole, enabling the facture to be imaged. The reflection strength is a function of the shear-wave polarization and the nature of the fracture, with the strongest response occurring from the shear waves intersecting a fluid/gas-filled fracture and polarizing in the fracture's strike direction. Another important aspect is that these shear waves have azimuthal sensitivity, providing a means to determine the fracture direction. These features enable the evaluation of fractures over a much larger area around the well, often in excess of 60 ft from the borehole, and even detecting major fractures that do not intersect the well. We will look at the application of this deep shear-wave imaging technology in several unconventional reservoirs across North America. Our review includes conventional methods and the deep shear-wave imaging analysis, showing its value in gaining important insight about the natural fracture system around the borehole, especially non-intersecting fractures. In addition, we will look at its application in mapping geologic structures in horizontal wells, demonstrating the ability to detect sub-seismic faults.
Identification of GBV-C hepatitis G RNA in chronic hepatitis C patients (1996)

Sera from patients with chronic hepatitis C were examined for the presence of GBV-C/HGV RNA by RT-PCR. The amplified products, derived from the 5' non-coding, NS3, and NS5a regions, were detected in 19 (19%) of the 100 HCV RNA-positive samples. Analysis of GBV-C/HGV prevalence rates revealed that dual infections are related to shared parenteral risk factors. Intravenous drug abuse and multiple transfusions were the factors clearly associated with a simultaneous HCV and GBV-C/HGV infection. Apart from this, patients with dual infections had a statistically significant lower mean age compared to those patients infected solely by HCV. Determination of HCV genotypes involved in GBV-C/HGV coinfection by RFLP analysis showed no correlation between the presence of GBV-C/HGV and a distinct HCV genotype. The study demonstrates that, based on the assessment of risk criteria, GBV-C/HGV is transmitted efficiently parenterally and is frequently linked to hepatitis C coinfection, regardless of HCV genotype.
Intermetallic Nanocrystal Discovery through Modulation of Atom Stacking Hierarchy (2022)

A library of compositionally and structurally well-defined Au-Cu alloy nanocrystals has been prepared via scanning probe block copolymer lithography. These libraries not only allow one to map compositional and structure space but also the conditions (e.g., cooling rate) required to access specific structures. This approach enabled the realization of a previously unobserved architecture, an intermetallic nanoprism, that is a consequence of hierarchical atom stacking. These structures exhibit distinctive diffraction patterns characterized by non-integer-index, forbidden spots, which serve as a diagnostic indicator of such structures. Inspection of the library's pseudospherical particles reveals a high-strain cubic-tetragonal interfacial configuration in the outer regions of the intermetallic nanocrystals. Since it is costly and time-consuming to explore the nanomaterials phase space via conventional wet-chemistry, this parallel kinetic-control approach, which relies on substrate- and positionally isolated particles, may lead to the rapid discovery of complex nanocrystals that may prove useful in applications spanning catalysis and plasmonic sensing.
Effect of substituents on the carbonyl and acetylene stretching frequencies of phenylbenzoylacetylenes (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of substituents on the carbonyl and acetylene stretching frequencies of phenylbenzoylacetylenesW. F. Winecoff III and D. W. Boykin Jr.Cite this: J. Org. Chem. 1973, 38, 14, 2544–2545Publication Date (Print):July 1, 1973Publication History Published online1 May 2002Published inissue 1 July 1973https://pubs.acs.org/doi/10.1021/jo00954a026https://doi.org/10.1021/jo00954a026research-articleACS PublicationsRequest reuse permissionsArticle Views84Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Microscale inverse acoustic band gap structure in aluminum nitride (2009)

This work presents the design and demonstration of a microscale inverse acoustic band gap (IABG) structure in aluminum nitride (AlN) with a frequency stop band for bulk acoustic waves in the very high frequency range. Conversely to conventional microscale acoustic band gaps, the IABG is formed by a two-dimensional periodic array of unit cells consisting of a high acoustic velocity material cylinder surrounded by a low acoustic velocity medium. The periodic arrangement of the IABG array induces scattering of incident acoustic waves and generates a stop band, whose center frequency is primarily determined by the lattice constant of the unit cell and whose bandwidth depends on the cylinder radius, the film thickness, and the size of the tethers that support the cylinder. A wide band gap (&amp;gt;13% of the center frequency) is formed by the IABG even when thin AlN films are used. The experimental response of an IABG structure having a unit cell of 8.6 μm and an AlN film thickness of 2 μm confirms the existence of a frequency band gap between 185 MHz and 240 MHz.
Growth and Biochemical Responses of Potato Cultivars under In Vitro Lithium Chloride and Mannitol Simulated Salinity and Drought Stress (2021)

Globally, drought and salinity stress critically constrain potato (<i>Solanum tuberosum</i> L.) production. Considering the impact of these stresses on crops and increasing food demand, insight into both tolerance and susceptibility is essential. The present study screens two potato cultivars, BARI-401 and Spunta, for their tolerance to simulated salinity and drought by in vitro LiCl and mannitol exposure. Plantlets treated with a range of LiCl (0, 10, 30, and 40 mM) and mannitol (0, 50, 100, 200, and 250 mM) concentrations were biochemically and physiologically characterized to assess their tolerance capacity. Shoot number, shoot length, root number, and root length were affected in both cultivars under higher LiCl and mannitol concentrations, even though Spunta was able to better maintain a higher shoot length under the 40 mM of LiCl and 250 mM of mannitol compared to BARI-401. The total phenol contents (TPC) in both cultivars were increased at the highest treatment concentration and the total flavonoids content (TFC) was decreased in BARI-401 as compared to Spunta. Higher free radical scavenging capacity (FRSC, low IC<sub>50</sub> value) was recorded in Spunta as compared to BARI-401 with increasing treatment concentrations, which supports the high antioxidant capacity of Spunta. An inverse correlation between polyphenol oxidase (PPO) and TPC was noted in both cultivars. Peroxidase dismutase (POD) activity was increased significantly in both cultivars for all treatments, but activity was highest overall in Spunta. These physiological and biochemical analyses of both cultivars suggest that cultivar Spunta is more tolerant to salinity and drought stress. Further open-field experiments are required to confirm these results.
A painful squat test provides limited diagnostic utility in CAM‐type femoroacetabular impingement (2013)

The maximal squat test was found to have marginal incremental diagnostic ability for CAM-type FAI. Its utility in the diagnostic evaluation of FAI remains limited. This survey elucidates areas of research for future studies relevant to the clinical diagnosis of FAI.
DL-AOD Positioning Algorithm for Enhanced 5G NR Location Services (2021)

In this paper we propose a Downlink Angle of Departure (DL-AOD) positioning algorithm for UE coordinates estimation using channel measurements. The channel estimation is performed with a multi-element transmit antenna array at the base station (gNB) and a single or multi-element receive antenna array at the user device (UE). The algorithm performs total receive channel power maximization with respect to the multi-dimensional space-time filter coefficients to derive an optimal DL-AOD solution. It is shown that the DL-AOD measurements may suffer from the Non-Line of Sight (NLOS) propagation phenomenon, specifically in indoor environments, that causes an angular bias relative to the true Line of Sight (LOS) direction. To reduce the impact of NLOS links on the resulting positioning accuracy the reliability function is introduced for correct weighting of the DL-AOD measurements in the positioning equations. The performance evaluation of the proposed algorithm is provided for the Industrial Internet of Things (I-IoT) use case.
ChemInform Abstract: Pd(II)‐Catalyzed ortho‐ or meta‐C—H Olefination of Phenol Derivatives. (2013)

Abstract Meta‐olefination generally proceeds with high selectivity &lt;83:17.
Designs for III-nitride edge-emitting laser diodes with tunnel junction contacts for low internal optical absorption loss (2022)

The lasing mode and internal optical absorption loss profiles of III-nitride edge-emitting laser diode (LD) designs operating at 440 nm were modeled using the transfer matrix method. These models indicate absorption losses are minimized in LDs utilizing tunnel junction (TJ) contacts that (1) optimize the TJ to be as close to fully depleted as possible; (2) spatially separate the metal contact from the lasing mode using lightly doped n-GaN located above the TJ; (3) in designs with optimized TJs, minimize the total thickness of p-type material. These features reduce absorption losses in the model, relative to comparable LD models with an unoptimized TJ contact or with a transparent conducting oxide p-contact, by up to 15.3% and 12.5%, respectively, while at the same time eliminating most or nearly all p-type material.