gebhart/patrepeval huggingface dataset:
Bearing Fault Diagnosis Using A Spectral Average Based Approach (2014)

The diagnosis of bearing health through the quantification of accelerometer data has been an area of interest for many years and has resulted in numerous signal processing methods and algorithms. In this paper, a new bearing fault diagnostic approach that combines envelope analysis, time synchronous resampling, and spectral averaging of vibration signals is presented. In this method, the accelerometer signal is first digitized simultaneously with tachometer signal acquisition. Then, the digitized vibration signal is band pass filtered to retain the information associated with the bearing defects. Finally, the tachometer signal is used to time synchronously resample the vibration data to compute spectral average and extract condition indicators for bearing fault diagnosis. The method is validated using the vibration output of seeded fault steel bearings on a bearing test rig. The result is an effective approach validated to diagnose all four bearing fault types: inner race, outer race, ball, and cage.
Three-Dimensional Elliptic Grid Generation with Fully Automatic Boundary Constraints (2009)

A new procedure for generating smooth uniformly clustered three-dimensional structured elliptic grids is presented here which formulates three-dimensional boundary constraints by extending the two-dimensional counterpart presented by the author earlier. This fully automatic procedure obviates the need for manual specification of decay parameters over the six bounding surfaces of a given volume grid. The procedure has been demonstrated here for the Mars Science Laboratory (MSL) geometries such as aeroshell and canopy, as well as the Inflatable Aerodynamic Decelerator (IAD) geometry and a 3D analytically defined geometry. The new procedure also enables generation of single-block grids for such geometries because the automatic boundary constraints permit the decay parameters to evolve as part of the solution to the elliptic grid system of equations. These decay parameters are no longer just constants, as specified in the conventional approach, but functions of generalized coordinate variables over a given bounding surface. Since these decay functions vary over a given boundary, orthogonal grids around any arbitrary simply-connected boundary can be clustered automatically without having to break up the boundaries and the corresponding interior or exterior domains into various blocks for grid generation. The new boundary constraints are not limited to the simply-connected regions only, but can also be formulated around multiply-connected and isolated regions in the interior. The proposed method is superior to other methods of grid generation such as algebraic and hyperbolic techniques in that the grids obtained here are C^2 continuous, whereas simple elliptic smoothing of algebraic or hyperbolic grids to enforce C^2 continuity destroys the grid clustering near the boundaries.
Target DNA detection by solid-state nanopores using gold nanoparticle probes (2020)

Abstract For target DNA detection with nanopores, the labeling of target DNA with large probes and the detection of its passage through a nanopore were examined. We labeled the target DNA with two gold nanoparticles (AuNPs). The surface of each AuNP was modified with a different single-stranded DNA (ssDNA) molecule that contained a complementary sequence to a different part of the target DNA so that the two AuNPs could capture one target DNA. The observed ionic current blockade when the AuNPs-labeled target DNA passed through a nanopore was significantly larger than that when nonlabeled DNA or a single AuNP probe passed through a nanopore. This result indicated that the presence of the target DNA in solution can be detected through nanopore measurements with two AuNP probes.
Suppl. Figures 1-10 from Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status (2023)

&lt;p&gt;Suppl. Fig.1. Nampt staining on normal Lymph Nodes; Suppl. Fig. 2. Nampt over-expression in BCMW.1 cells. Suppl. Fig. 3. Dose-response effect curves of FK866; Suppl. Fig. 4. Expression levels of Nampt in WM cells after BTK inhibition (GSE65816); Suppl. Fig. 5. MYD88 L265P and MYD88 WT expressing cells treated with FK866, ibrutinib, or both. Suppl. Fig. 6. MYD88 L265P (BCMW.1 and MWCL-1) and MYD88 WT ( MEC.1 and RL) expressing cells were treated with an inhibitor of Nampt (FK866), BTK (ibrutinib), or both. Suppl. Fig. 7. Effects of co-treatment on primary tumor cells. Suppl. Fig. 8. Densitometric analysis of WB represented in Figure 3B. Suppl. Fig. 9. Rescue experiments with exogenous NAD. Suppl. Fig. 10. Effects of co-treatments on animals body weight.&lt;/p&gt;
Particle Filters For Positioning In Wireless Networks (2002)

Publication in the conference proceedings of EUSIPCO, Toulouse, France, 2002
A Study on Management Efficiency for Local public enterprise of Sewage in Korea: Exploring Research for Development Alternatives through International Cases Comparison (2020)

기후변화와 도시화, 시민의 물 복지요구 확대 등 급격한 대내외적 여건 변화, 경쟁력 있는 하수도 서비스를 제공을 위해서 우리나라 지방하수도의 변화가 필요하다. 그러나, 지방하수도 사업은 대부분의 자치단체에서 매년 적자를 발생하고 있으며, 효율적 사업운영과 실적개선의 방향성을 제대로 제시하지 못하고 있다. 본 연구에서는 최근의 일본 클리어워터 오사카, 싱가포르 PUB, 영국 템즈 워터 등 국외 주요 운영사례를 비교 분석함으로써 향후 우리나라 지방하수도 사업 방향과 대응을 위한 시사점을 모색하고 있다. 특히, 조직운영체계, 경영전략분석, 시설관리운영 등의 측면에서 지방하수도 경영효율화에 대한 다음의 정책적 논리와 시사점을 제공한다. 첫째, 상하수도 통합관리 및 하수처리 통합시설 구축할 수 있도록 투자가 필요하다. 둘째, 하수도 분야의 전문성 확보 및 인재양성은 경영효율화를 위해 필수적으로 전제되어야 한다. 셋째, 하수도사업소의 경영효율화를 위해서는 출자기업 전환 등 다양한 운영방식을 통해 해외 진출을 통한 글로벌 경쟁력 확보가 요구된다.
A direct-measurement thin-film heat flux sensor array (2010)

A new thin-film heat flux array (HFA) was designed and fabricated using a series of nickel/copper differential thermocouples deposited onto a thin Kapton® polyimide film. A special bank of amplifiers was designed and built to measure the signal from the HFA. Calibrations were performed to determine the gage's sensitivity and temporal response. The HFA produced signals of 42 µV (W cm−2)−1 with a measured first-order response time of 32 ms. The apparent thermal conductivity of the Kapton used was larger than what is usually reported. The design methodology, construction techniques, steady-state and transient calibrations, and a test case are all discussed.
Fluorescent Tissue Transglutaminase Substrates for Tumor Boundary Imaging (2007)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text C. Pan, J. P. Haushalter, K. Amin, Z. Haroon, and G. W. Faris, "Fluorescent Tissue Transglutaminase Substrates for Tumor Boundary Imaging," in Frontiers in Optics 2007/Laser Science XXIII/Organic Materials and Devices for Displays and Energy Conversion, OSA Technical Digest (CD) (Optica Publishing Group, 2007), paper JWC22. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Improving energy consumption of NoC based architectures through approximate communication (2018)

This paper presents an approximate communication technique aimed at improving the energy efficiency of Network-on-Chip (NoC) based architectures. The basic idea is a selective adjustment, at run-time, of the voltage swing of the links of the NoC to obtain a trade-off between the communication energy consumption and the accuracy of the running application. The proposed technique is applied to a case study, namely, a JPEG encoder resulting in an energy saving up to 70% with a negligible impact on the quality of the compressed image.
Small Molecule–Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1 (2018)

Oncogenic mutation of RAS results in aberrant cellular signaling and is responsible for more than 30% of all human tumors. Therefore, pharmacologic modulation of RAS has attracted great interest as a therapeutic strategy. Our laboratory has recently discovered small molecules that activate Son of Sevenless (SOS)-catalyzed nucleotide exchange on RAS and inhibit downstream signaling. Here, we describe how pharmacologically targeting SOS1 induced biphasic modulation of RAS-GTP and ERK phosphorylation levels, which we observed in a variety of cell lines expressing different RAS-mutant isoforms. We show that compound treatment caused an increase in phosphorylation at ERK consensus motifs on SOS1 that was not observed with the expression of a non-phosphorylatable S1178A SOS1 mutant or after pretreatment with an ERK inhibitor. Phosphorylation at S1178 on SOS1 is known to inhibit the association between SOS1 and GRB2 and disrupt SOS1 membrane localization. Consistent with this, we show that wild-type SOS1 and GRB2 dissociated in a time-dependent fashion in response to compound treatment, and conversely, this interaction was enhanced with the expression of an S1178A SOS1 mutant. Furthermore, in cells expressing either S1178A SOS1 or a constitutively membrane-bound CAAX box tagged SOS1 mutant, we observed elevated RAS-GTP levels over time in response to compound, as compared with the biphasic changes in RAS-GTP exhibited in cells expressing wild-type SOS1. These results suggest that small molecule targeting of SOS1 can elicit a biphasic modulation of RAS-GTP and phospho-ERK levels through negative feedback on SOS1 that regulates the interaction between SOS1 and GRB2. <i>Mol Cancer Ther; 17(5); 1051-60. ©2018 AACR</i>.
ECHO: Enhanced Conditional Handover boosted by Trajectory Prediction (2021)

Conditional handover (CHO) has been introduced in 5G to improve mobility robustness, namely, to reduce the number of handover failures by preparing target Base Stations (BSs) in advance and allowing the user to decide when to make a handover. This algorithm constantly prepares and releases BSs, thereby adapting to the fast changing radio condition. A user might make a handover to a distant BS that has a favorable channel only for a short time due to signal fluctuations. This increases the handover rate and might result in a Radio Link Failure (RLF) afterwards. Moreover, the constant preparation and release of BSs leads to an increased exchange of control messages between the user, the serving BS and all target BSs. Hence, there is a need to carefully select the target BSs. Therefore, we propose the Enhanced CHO (ECHO) scheme that uses trajectory prediction to prepare the BSs along the user's path. To achieve this, we also propose a Sequence to Sequence (Seq2Seq) mobility prediction model. ECHO with only one prepared BS (ECHO-1) outperforms CHO with three prepared BSs. ECHO-1 reduces the handover rate by 23 percent and the RLF rate by 77 percent, while also reducing the number of control messages in the network by 69 percent.
Preclinical Development of a Lentiviral Vector for Gene Therapy of X-Linked Severe Combined Immunodeficiency (2018)

X-linked severe combined immunodeficiency (SCID-X1) is caused by mutations in the interleukin-2 receptor γ chain gene (IL2RG), and it is characterized by profound defects in T, B, and natural killer (NK) cell functions. Transplantation of hematopoietic stem/progenitor cells (HSPCs) genetically corrected with early murine leukemia retrovirus (MLV)-derived gammaretroviral vectors showed restoration of T cell immunity in patients, but it resulted in vector-induced insertional oncogenesis. We developed a self-inactivating (SIN) lentiviral vector carrying a codon-optimized human IL2RG cDNA driven by the EF1α short promoter (EFS-IL2RG), and we tested its efficacy and safety <i>in vivo</i> by transplanting transduced Il2rg-deficient Lin<sup>-</sup> HSPCs in an <i>Il2rg</i><sup>-/-</sup>/<i>Rag2</i><sup>-/-</sup> mouse model. The study showed restoration of T, B, and NK cell counts in bone marrow and peripheral blood and normalization of thymus and spleen cellularity and architecture. High-definition insertion site analysis defined the EFS-IL2RG genomic integration profile, and it showed no sign of vector-induced clonal selection or skewing in primarily and secondarily transplanted animals. The study enables a phase I/II clinical trial aimed at restoring both T and B cell immunity in SCID-X1 children upon non-myeloablative conditioning.
Gold/Molecule/p$^+$ Si Devices: Variable Temperature Electronic Transport (2009)

Although a considerable amount of experimental and theoretical work has been devoted to nanoelectronic systems with molecular components, relatively little work has been done on molecular electronic devices on technologically relevant substrates such as silicon. Metal-molecule-semiconductor (MMS) studies have generally focused on structures in which the semiconductor barrier is dominant or treated the semiconductor as a metallic contact. In this paper, we present measured temperature-dependent current-voltage characteristics of gold/molecular monolayer/p <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> silicon devices. We explore how the bandstructure of the degenerately doped semiconductor, molecular electronic properties, surface states, and molecular vibronic properties contribute to the electronic transport. We also demonstrate that molecule-dominated behavior can be achieved in a MMS device by appropriate engineering of the contact electronic properties.
Extracellular matrix-modulated expression of human cell surface glycoproteins A42 and J143. Intrinsic and extrinsic signals determine antigenic phenotype. (1986)

We have used serologic, biochemical, and genetic methods to characterize two stage-specific human differentiation antigens of neural and melanocytic cells: A42 (57,000 Mr glycoprotein) and J143 (140,000/30,000 Mr glycoprotein). The genes determining A42 and J143 cell surface expression in rodent-human hybrids were chromosomally mapped, and the respective human chromosomes were introduced into rodent cells derived from distinct differentiation lineages. Serologic analysis of the resulting hybrid clones has permitted the identification of two types of regulatory signals determining A42 and J143 expression. First, both antigens are expressed in hybrids constructed with antigen-positive human cells and also in certain hybrids constructed with antigen-negative human cells, indicating that intrinsic signals provided by the differentiation program of the rodent fusion partner induce antigen expression. Second, a series of human-mouse neuroblastoma hybrids, which are A42- or J143- when cultured on plastic surfaces, can be induced to express the antigens when cultured on substrates coated with extracellular matrix (ECM) produced by bovine corneal endothelial cells or fibronectin. This induction of antigen expression by extrinsic, ECM-derived signals is accompanied in the neuroblastoma hybrids by increased substrate adhesiveness and cell spreading and by characteristic changes in cell morphology. A similar program of phenotypic changes is also seen in spontaneous variants of human neuroblastoma and Ewing's sarcoma cells and in ECM-induced Ewing's sarcoma cells. These findings suggest that ECM-derived signals have a role analogous to mitogens and soluble differentiation factors in modulating differentiation phenotypes and tissue-specific patterns of cell surface antigen expression.
Accurate eye center localization using Snakuscule (2016)

Estimating eye centers is an important computer vision problem with several applications. In the past, eye center localization was constrained by the use of special hardware such as infrared cameras. Methods that estimate eye centers based on visible light have also been suggested in the literature, but these methods are inaccurate when used with low resolution images and wide ranges of lighting. We propose a novel method that can be used to detect eye centers efficiently, even with low resolution images provided by a webcam. Our method takes into consideration the circular nature of the iris and its intensity difference as compared to the sclera. It then uses an energy based active contour called Snakuscule for capturing the iris. We test our algorithm's robustness towards changes in pose, illumination and scale using the BioID database and Yale Face Database B. Our method compares well with existing state-of-the-art techniques in terms of accuracy, is easy to implement and exhibits real-time performance.
Alternative implementation techniques for Web text visualization (2004)

We present an approach for building text visualizations that avoids using plug-ins or clients based on languages like Java. Instead we propose to make the search engine application more aware of the visualization process and use the Web browser standard features to do the rendering work. We demonstrate the ideas with a text visualization metaphor implementation that is part of a search engine.
Prediction of users' facial attractiveness on an online dating website (2017)

Online dating websites are popular platforms for adults to search for their life partners. Because on online dating websites, a user's profile image is an important factor determining other's impressions, we focus on profile images and analyze users' visual attractiveness in this study. Facial attractiveness is strongly related to our perception of aesthetics and therefore we believe our investigation can somewhat contribute to artwork analysis. We use pre-trained convolutional neural networks (CNN) to extract visual features and propose a new method to rank users' attractiveness from their online dating interactions. For both genders, we predict users' facial attractiveness by supervised machine learning. Our experimental results show that deep representations of profile images are powerful to capture facial attributes' differences and perform well in predicting users' attractiveness. The correlation coefficient of 0.462 for male users and the correlation coefficient of 0.387 for females users is obtained for regression. The accuracy of 75% for females and the accuracy of 78.8% for males is obtained for 2-level classification.
Specific polarizability of sand–clay mixtures with varying ethanol concentration (2017)

We utilise a concept of specific polarizability (<i>c</i> <sub><i>s</i></sub> ), represented as the ratio of mineral-fluid interface polarization per pore-normalised surface area <i>S</i> <sub><i>p</i></sub> , to demonstrate the influence of clay-organic interaction on complex conductivity measurements. Complex conductivity measurements were performed on kaolinite- and illite-sand mixtures as a function of varying ethanol (EtOH) concentration (10% and 20% v/v). The specific surface area of each clay type and Ottawa sand was determined by nitrogen-gas-adsorption Brunauer-Emmett-Teller method. We also calculated the porosity and saturation of each mixture based on weight loss of dried samples. Debye decomposition, a phenomenological model, was applied to the complex conductivity data to determine normalised chargeability (<i>m</i> <sub><i>n</i></sub> ). Specific polarizability estimates from previous complex conductivity measurements for bentonite-sand mixtures were compared with our dataset. The <i>c</i> <sub><i>s</i></sub> for all sand-clay mixtures decreased as the EtOH concentration increased from 0% to 10% to 20% v/v. We observe similar <i>c</i> <sub><i>s</i></sub> responses to EtOH concentration for all sand-clay mixtures. Analysis of variance with a level of significance <i>α</i> = 0.05 suggests that the suppression in <i>c</i> <sub><i>s</i></sub> responses with increasing EtOH concentration was statistically significant for all sand-clay mixtures. On the other hand, real conductivity showed only 10% to 20% v/v changes with increasing EtOH concentration. The <i>c</i> <sub><i>s</i></sub> estimates reflect the sensitivity of complex conductivity measurements to alteration in surface chemistry at available surface adsorption sites for different clay types, likely resulting from ion exchange at the clay surface and associated with kinetic reactions in the electrical double layer of the clay-water-EtOH media. Our results indicate a much larger influence of specific surface area and ethanol concentration on clay-driven polarization relative to changes in clay mineralogy.
Multi‐dose drug dispensing as a tool to improve medication adherence: A study in patients using vitamin K antagonists (2017)

Adherence improved after initiation of MDD. Compared with instructing patients, MDD was associated with better adherence within 1 month but was associated with similar improvement after 4 months.
AlGaAs ridge laser with 33% wall-plug efficiency at 100 °C based on a design of experiments approach (2016)

Upcoming applications for semiconductor lasers present limited thermal dissipation routes demanding the highest efficiency devices at high operating temperatures. This paper reports on a comprehensive design of experiment optimisation for the epitaxial layer structure of AlGaAs based 840 nm lasers for operation at high temperature (100 °C) using Technology Computer-Aided Design software. The waveguide thickness, Al content, doping level, and quantum well thickness were optimised. The resultant design was grown and the fabricated ridge waveguides were optimised for carrier injection and, at 100 °C, the lasers achieve a total power output of 28 mW at a current of 50 mA, a total slope efficiency 0.82 W A−1 with a corresponding wall-plug efficiency of 33%.
Supplemental Dataset 1 from Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression (2023)

&lt;p&gt;Ensembl IDs for genes used to predict smoking status.&lt;/p&gt;
Proceedings of the 27th International Conference on Parallel Architectures and Compilation Techniques (2018)

The scope of the PACT conference series is more relevant than ever as we face the diminishing return of Moore's Law and the urgent need to squeeze more performance out of our ubiquitous parallel computer platforms.
Essential Roles of GABA Transporter-1 in Controlling Rapid Eye Movement Sleep and in Increased Slow Wave Activity after Sleep Deprivation (2013)

GABA is the major inhibitory neurotransmitter in the mammalian central nervous system that has been strongly implicated in the regulation of sleep. GABA transporter subtype 1 (GAT1) constructs high affinity reuptake sites for GABA and regulates GABAergic transmission in the brain. However, the role of GAT1 in sleep-wake regulation remains elusive. In the current study, we characterized the spontaneous sleep-wake cycle and responses to sleep deprivation in GAT1 knock-out (KO) mice. GAT1 KO mice exhibited dominant theta-activity and a remarkable reduction of EEG power in low frequencies across all vigilance stages. Under baseline conditions, spontaneous rapid eye movement (REM) sleep of KO mice was elevated both during the light and dark periods, and non-REM (NREM) sleep was reduced during the light period only. KO mice also showed more state transitions from NREM to REM sleep and from REM sleep to wakefulness, as well as more number of REM and NREM sleep bouts than WT mice. During the dark period, KO mice exhibited more REM sleep bouts only. Six hours of sleep deprivation induced rebound increases in NREM and REM sleep in both genotypes. However, slow wave activity, the intensity component of NREM sleep was briefly elevated in WT mice but remained completely unchanged in KO mice, compared with their respective baselines. These results indicate that GAT1 plays a critical role in the regulation of REM sleep and homeostasis of NREM sleep.