gebhart/patrepeval huggingface dataset:
Early adenosine receptor activation ameliorates spinal cord reperfusion injury (2008)

Early therapy with ATL-146e provided better protection in this study; therefore, therapy should not be delayed until there is evidence of ischemic neurological deficit. This study suggests that adenosine receptor activation is most effective as a preventive strategy at reperfusion for optimal protection in spinal cord ischemia-reperfusion injury.
Supplementary Figures 1 - 4, Tables 1 - 3 from Essential Role of Aldehyde Dehydrogenase 1A3 for the Maintenance of Non–Small Cell Lung Cancer Stem Cells Is Associated with the STAT3 Pathway (2023)

&lt;p&gt;PDF file - 465K, Supplementary Table S1. The correlation between ALDH1A3 protein expression and percentage of ALDH+ cells in NSCLC lines (Data for Figure 2D). Supplementary Table S2. Incidence of xenograft tumors derived from control or ALDH1A3 knockdown lung cancer cells. Supplementary Table S3. The association between ALDH1A3 protein expression and clinicopathological variables for 455 NSCLC patient samples. Figure S1. ALDH profiling of 8 NSCLC lines using the flow cytometry based Aldefluor assay. Figure S2. Anchorage dependent colony formation efficiency was determined by growing serial dilutions of sorted ALDH+ and ALDH- cells for 2 weeks in liquid culture. Figure S3. A, ALDH1A3 protein expression in a set of NSCLC lines was detected by western blots. The corresponding percentage of ALDH+ cells was analyzed by Aldefluor assay. B, western blot showed ALDH1A1 protein expression in certain HBEC and NSCLC lines. C, ALDH1A3 was knocked down using three siRNAs in a panel of NSCLC lines with different driver mutations followed by liquid colony formation assays. RT-PCR was performed to examine ALDH1A3 mRNA expression. Figure S4. Ectopic expression of ALDH1A3 does not affect tumorigenicity of lung cancer cells.&lt;/p&gt;
Acoustic communications and autonomous underwater vehicles (2004)

Acoustic communications systems used on autonomous underwater vehicles (AUVs) provide supervisory control, access to real-time data, and also allow multiple vehicles to cooperate in undertaking adaptive sampling missions. However, the use of acoustic systems on AUVs presents special challenges because of limited space for optimal placement of transducers, and potential conflicts with other acoustic systems such as side-scan sonars and transponders. In addition, radiated and structure-borne acoustic interference from thrusters and actuators reduces the sensitivity of on-board receivers. Recent work in acoustic communications and AUVs has included combining some navigation functions into communications equipment, development of operating modes that remove conflicts between different subsystems, design of vehicle components to avoid or remove interference, and other approaches to improving performance. While these efforts have been successful for specific installations, many challenges remain. This talk addresses problems and solutions for supervised and completely autonomous multi-vehicle communications to support complex AUV missions. Also presented are recent results which demonstrate that acoustic communications can be used successfully on a variety of AUV platforms for many different applications. [Work supported by ONR.]
Rigorous analysis of the reflectarray radiating elements: Characterisation of the specular reflection effect and the mutual coupling effect (2007)

International audience
Inferring Data Flow in Semantic Web Service Composition (2011)

Automation of web service composition is one of the most interesting challenges facing the semantic web today. Despite approaches which are able to infer partial order on services, data flow (i.e., the way data is exchanged among services) remains implicit and difficult to be inferred and automatically generated. Since web services have been enhanced with formal semantic descriptions, it becomes conceivable to exploit and reason on their semantic links (i.e., semantic matching between their functional output and input parameters) to infer data flow. Our approach has been directed to meet the main challenges facing the latter problem i.e., how to effectively i) guarantee whether a data flow is well-formed and ii) infer data flow between services based on their Description Logics (DL) descriptions. To this end, we apply constructive DL reasoning abduction, contraction and introduce the non standard DL reasoning join to model and infer data flow in compositions. The preliminary evaluation results showed high efficiency and effectiveness of the proposed approach.
View adaptive detection and distributed site wide tracking (2007)

Using a detect and track paradigm, we present a surveillance framework where each camera uses local resources to perform real-time person detection. These detections are then processed by a distributed site-wide tracking system. The detectors themselves are based on boosted user-defined exemplars, which capture both appearance and shape information. The detectors take integral images of both intensity and Sobel responses as input. This data representation enables efficient processing without relying on background subtraction or other motion cues. View-specific person detectors are constructed by iteratively presenting the boosting algorithm with training data associated with each individual camera. These detections are then transmitted from a distributed set of tracking clients to a server, which maintains a set of site-wide target tracks. Automatic calibration methods allow for tracking to be performed in a ground plane representation, which enables effective camera hand-off. Factors such as network latencies and scalability will be discussed.
Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14 th century (2022)

Abstract We report genome-wide data for 33 Ashkenazi Jews (AJ), dated to the 14 th century, following a salvage excavation at the medieval Jewish cemetery of Erfurt, Germany. The Erfurt individuals are genetically similar to modern AJ and have substantial Southern European ancestry, but they show more variability in Eastern European-related ancestry than modern AJ. A third of the Erfurt individuals carried the same nearly-AJ-specific mitochondrial haplogroup and eight carried pathogenic variants known to affect AJ today. These observations, together with high levels of runs of homozygosity, suggest that the Erfurt community had already experienced the major reduction in size that affected modern AJ. However, the Erfurt bottleneck was more severe, implying substructure in medieval AJ. Together, our results suggest that the AJ founder event and the acquisition of the main sources of ancestry pre-dated the 14 th century and highlight late medieval genetic heterogeneity no longer present in modern AJ.
Effect of monomer sequencing on the phase behavior of novel block copolymer/homopolymer blends (1996)

Blends consisting of a block copolymer and a parent or block-specific homopolymer exhibit macrophase or microphase separation, depending on (i) the homopolymer chain length relative to that of the host block, (ii) the bulk composition of the blend, and (iii) the state of the copolymer. Recent studies of copolymer/homopolymer blends composed of block, random or alternating copolymers have shown that monomer sequencing plays a crucial role in phase behavior and morphological development. In this work, we examine this effect more closely by probing local segment interactions in both the ordered and disordered block copolymer regimes. In the disordered regime, the effects of blend concentration and molecular weight disparity were analyzed using a poly[(styrene-r-isoprene){prime}-b-(styrene-r-isoprene){double_prime}] (S/I) {prime}-b-(S/I){double_prime} copolymer and three homopolystyrenes of varying molecular weight. To probe segmental interactions in the ordered regime, a series of poly[styrene-b-(styrene-r-isoprene)-b-isoprene] S(S/I)I triblock copolymers has been blended with a single low-molecular-weight homopolystyrene. The phase behavior of all these blends has been examined with transmission electron microscopy (TEM). Electron microtomography was also used to produce the first relatively high-resolution 3-D reconstruction of the L{sub 3} morphology in a copolymer-dilute blend.
Prediction of Adenomyosis Diagnosis based on MRI (2022)

Study Objective: Development of a prediction tool for histopathological adenomyosis diagnosis after hysterectomy based on MRI and clinical parameters. Design: Single-centre retrospective cohort study Setting: Gynaecological department of a referral hospital from 2007-2022. Population: 296 women undergoing hysterectomy with preoperative pelvic MRI Methods: MRI’s were retrospectively assessed for adenomyosis markers (junctional zone (JZ) parameters, high signal intensity foci (HSI) foci) in a blinded fashion. A multivariate regression model for histopathological adenomyosis diagnosis was developed based on MRI and clinical variables from univariate analysis with p&gt;0.10 and factors deemed clinically relevant. Results: 131/296 women (44.3%) had histopathological adenomyosis. Patients were of comparable age at hysterectomy, BMI and clinical symptoms, p&gt;0.05. Adenomyosis patients more often had undergone a curettage (22.1% vs. 8.9%, p=0.002), a higher mean JZ thickness (9.40 vs. 8.35mm, p &lt;.001), maximal JZ thickness (16.00 vs. 13.40mm, p&lt;.001), mean JZ/myometrium ratio (0.56 vs. 0.49, p=.040), and JZ differential (8.60 vs. 8.15mm, p=.003). Presence of HSI foci was a strong predictor for adenomyosis (39.7% vs. 8.9%, p&lt;.001). Based on the parameters age and BMI, history of curettage, dysmenorrhoea, abnormal uterine bleeding (AUB), mean JZ, JZ Differential  5mm, JZ/myometrium ratio &gt;.40, and presence of HSI Foci, a predictive model was created with a good Area Under the Curve (AUC) of .776. Conclusions: This is the first study to create a diagnostic tool based on MRI and clinical parameters for adenomyosis diagnosis. After sufficient external validation, this model could function as a useful clinical-decision making tool in women with suspected adenomyosis.
Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal (2011)

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTTargeting the Liver Stage of Malaria Parasites: A Yet Unmet GoalTiago Rodrigues†, Miguel Prudêncio‡, Rui Moreira*†, Maria M. Mota‡, and Francisca Lopes†View Author Information† Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, 1649-019 Lisbon, Portugal‡ Unidade de Malária, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal*Phone: +351 217946400. Fax: +351 217946470. E-mail: [email protected]Cite this: J. Med. Chem. 2012, 55, 3, 995–1012Publication Date (Web):November 28, 2011Publication History Received15 August 2011Published online21 December 2011Published inissue 9 February 2012https://pubs.acs.org/doi/10.1021/jm201095hhttps://doi.org/10.1021/jm201095hreview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views3165Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anatomy,Infectious diseases,Parasites,Peptides and proteins,Rodent models Get e-Alerts
A model study of capacitive micromachined ultrasonic transducers fabricated using atomic layer deposition process. (2004)

In this paper, we present the model study of capacitive micromachined ultrasonic transducers (CMUTs) fabricated by atomic layer deposition (ALD) technology, which uses a self-limiting binary reaction process to produce ultra-thin membranes. Advantages of ALD include precise control of membrane thickness, lower cost due to a reduction in the number of fabrication steps, the potential to use a large variety of materials, and increased reliability due to the enhanced surface quality of the membranes. These capabilities promise fabrication of transducers with superior operating characteristics. However, no study has yet documented sensitivity and power requirements for CMUTs created using ALD. We present here a first-order mechanical and equivalent circuit analysis along with a fabrication process to create and characterize CMUTs using ALD. Simulation results show that these systems have the potential for excellent sensitivity and decreased power requirements. Work to test the fabricated elements is currently underway.
Nonsteroidal Progesterone Receptor Modulators: Structure Activity Relationships (2005)

Progesterone, acting primarily via the progesterone receptor (PR), plays an essential role in the regulation of female reproduction. Steroidal progestins (i.e., PR agonists) are commonly used in women's health, such as in contraception and hormone therapy and for the treatment of gynecological disorders. Recent studies in women and in nonhuman primates also indicate that PR antagonists may have potential applications in contraception and for the treatment of reproductive disorders such as fibroids and endometriosis. Currently, all clinically available PR agonists and antagonists are steroidal compounds. They often cause various side effects due to their functional interactions with other steroid receptors or because of effects associated with their steroidal metabolites. In an effort to identify more receptor-selective and structurally diverse compounds that may render clinical advantages over steroidal PR ligands, numerous receptor-selective novel nonsteroidal PR agonists and antagonists have been discovered. This review focuses on the structure activity relationships and the biological profile of the nonsteroidal PR modulators discovered in the last decade.
Numerical Estimation of Nonlinear Impairments in a 62.5 µm MMF for MDM Transmission (2018)

The nonlinear propagation in a multimode fiber using 78 spatial modes is investigated numerically. We show that nonlinear impairments are no obstacle for using fibers with such a high mode count for mode-division multiplexing.
TECHNIQUE OF ENDOPYELOTOMY WITH THE ACUCISE CUTTING BALLOON (2000)

Historically, upper urinary tract strictures have been managed by open surgery. It was after the research studies by Davis in the early 1940’s that clinical foundations for current endourological management were set. When describing his “intubated ureterotomy “ Davis stated that a stented incision of the ureteropelvic junction (UPJ) took one week for complete epithelization and six for muscular regeneration. Endopyelotomy has withstood the test of time and is currently considered first line therapy for primary and secondary UPJ obstruction in adults and secondary UPJ obstruction in children. Acucise endopyelotomy has the major advantage of being performed under fluoroscopic imaging without the need for ureteroscopy, thereby reducing the need for general anesthesia and prolonged hospitalization. Herein we discuss the procedural aspects of Acucise endopyelotomy.
ChemInform Abstract: Development of Practical Methodologies for the Synthesis of Functionalized Benzoboroxoles. (2010)

Abstract 2‐Formylboronic acids (I) undergo Baylis—Hillman reaction with activated olefins (II) or Zn‐mediated reaction with bromides (IV) to yield target compounds (III) and homologues of type (V).
Quality data - a prerequisite for assessing quality of care (2000)

European Society of Anaesthesiologists; 8th Annual Meeting with the Austrian International Congress; Vienna, Austria, 1-4 April 2000
Fabrication and Electronic Properties of CZTSe Single Crystals (2014)

CZTSe single crystals of different compositions were fabricated by solid-state reaction of elements in a sealed ampoule below the melt temperature. About 2-5-mm crystals were achieved without a flux agent, which, when present, can potentially affect defect properties in the material. A broad PL peak is observed with significant luminescence below the bandgap similar to the literature reports of band-tailing from disorder. Cu-poor and near stoichiometric compositions were prepared, and electronic and transport properties were analyzed with Hall and temperature-conductivity measurements. Intragrain measurements showed record hole mobilities for pure CZTSe in excess of 100 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /(V · s). Carrier concentrations ranged from 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">16</sup> -10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">19</sup> and correlated with Cu concentration. Temperature conductivity analysis suggests Mott variable-range hopping, as has been reported in CZTS and other disordered semiconductors, while a metal-insulator transition was seen for high-Cu concentrations. The results of transport and PL measurements are suggestive of a highly disordered material, despite long fabrication times conducive to near-equilibrium bulk conditions.
Phosphorylation of TET Proteins Is Regulated via O-GlcNAcylation by the O-Linked N-Acetylglucosamine Transferase (OGT) (2015)

TET proteins oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine and thus provide a possible means for active DNA demethylation in mammals. Although their catalytic mechanism is well characterized and the catalytic dioxygenase domain is highly conserved, the function of the regulatory regions (the N terminus and the low-complexity insert between the two parts of the dioxygenase domains) is only poorly understood. Here, we demonstrate that TET proteins are subject to a variety of post-translational modifications that mostly occur at these regulatory regions. We mapped TET modification sites at amino acid resolution and show for the first time that TET1, TET2, and TET3 are highly phosphorylated. The O-linked GlcNAc transferase, which we identified as a strong interactor with all three TET proteins, catalyzes the addition of a GlcNAc group to serine and threonine residues of TET proteins and thereby decreases both the number of phosphorylation sites and site occupancy. Interestingly, the different TET proteins display unique post-translational modification patterns, and some modifications occur in distinct combinations. In summary, our results provide a novel potential mechanism for TET protein regulation based on a dynamic interplay of phosphorylation and O-GlcNAcylation at the N terminus and the low-complexity insert region. Our data suggest strong cross-talk between the modification sites that could allow rapid adaption of TET protein localization, activity, or targeting due to changing environmental conditions as well as in response to external stimuli.
An iPRES‐W Coil Array for Simultaneous Imaging and Wireless Localized B0 Shimming of the Cervical Spinal Cord (2022)

The iPRES-W coil array can perform imaging and wireless localized B<sub>0</sub> shimming of the spinal cord with no SNR degradation, with minimal change in wireless performance and without any scanner modifications or additional antenna systems within the scanner bore.
Management of Multimedia Semantics Using MPEG-7 (2011)

This chapter presents the ISO/IEC MPEG-7 Multimedia Content description Interface Standard from the point of view of managing semantics in the context of multimedia applications. We describe the organisation and structure of the MPEG-7 Multimedia Description schemes which are metadata structures for describing and annotating multimedia content at several levels of granularity and abstraction. As we look at MPEG-7 semantic descriptions, we realise they provide a rich framework for static descriptions of content semantics. As content semantics evolves with interaction, the human user will have to compensate for the absence of detailed semantics that cannot be specified in advance. We explore the practical aspects of using these descriptions in the context of different applications and present some pros and cons from the point of view of managing multimedia semantics.Request access from your librarian to read this chapter's full text.
Membrane Trafficking Pathways inAlzheimer's Disease (2012)

Membrane proteins are constantly being trafficked in cells and the relevant proteins in Alzheimer's disease (AD), such as the amyloid precursor protein (APP) and its processing enzymes, are not exempted from that. Molecular cell biologists have been endeavoring to ascertain a roadmap for APP processing and trafficking in various cell types including neurons. This has led to the identification of numerous regulatory sorting mechanisms, protein-protein interactions and lipidic microenvironments that largely define how and where the substrate APP meets its processing enzymes. However, the cell biology of tau, and the formation of neurofibrillary tangles, has long been regarded as a separate field. Nonetheless, recent progress is bringing both worlds together in a new paradigm on how Aβ toxicity and tau are physiologically connected. Here, we discuss an update of our current appraisal on how membrane trafficking may play an important role in the pathogenesis of the disease and how this could be exploited for effective therapy.
Novel Bis-arylPheDOT Synthons for Electrochromic Polymers (2009)

Abstract Two terthiophenes incorporating the synthon 3,4-(1,2-phenylenedioxy)thiophene (PheDOT) have been developed. Specifically, 2,5-bisthienyl-3,4-(1,2-phenylenedioxy)thiophene (BTh-PheDOT 1) and 2,5-bisethylenedioxythienyl-3,4-(1,2-phenylenedioxy)thiophene (BEDOT-PheDOT 2) were electropolymerized to form electroactive polymer films (P1 and P2) that switched between two highly colored states with the more electron-rich EDOT derivative P2 observed to switch at a lower potential. Additionally, both P1 and P2 displayed moderate to low optical bandgaps of 1.8 and 1.6 eV, respectively. Crystal structures of BTh-PheDOT showed the monomer to be nearly planar with π -stacking observable between monomers. These findings demonstrate the potential of PheDOT as an electroactive synthon for the formation of well-ordered systems. Keywords: 3,4-(1,2-phenylenedioxy)thiopheneelectropolymerizationelectrochromic films Acknowledgements We gratefully acknowledge funding of this work by the AFOSR (FA9550-09-1-0320).