gebhart/patrepeval huggingface dataset:
Pleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment (2022)

Abstract Metastatic cancer cells adapt to thrive in secondary organs. To investigate metastatic adaptation, we performed transcriptomic analysis of metastatic and non-metastatic murine breast cancer cells. We found that pleiotrophin (PTN), a neurotrophic cytokine, is a metastasis-associated factor that is expressed highly by aggressive breast cancers. Moreover, elevated PTN in plasma correlated significantly with metastasis and reduced survival of breast cancer patients. Mechanistically, we find that PTN activates NF-kB in cancer cells leading to altered cytokine production, subsequent neutrophil recruitment and an immune suppressive microenvironment. Consequently, inhibition of PTN, pharmacologically or genetically, reduces the accumulation of tumor associated neutrophils and reverts local immune suppression resulting in increased T cell activation and attenuated metastasis. Furthermore, inhibition of PTN significantly enhanced the efficacy of immune checkpoint blockade + chemotherapy in reducing metastatic burden in mice. These findings establish PTN as a previously unrecognized driver of a pro-metastatic immune niche and thus represents a promising therapeutic target for the treatment of metastatic breast cancer.
Cold start strategy and system for gasoline direct injection compression ignition engine (2023)

A method for starting a compression ignition engine having at least one cylinder with a reciprocating piston located therein, an intake valve configured to control the intake of air to an intake port of the cylinder and an exhaust valve configured to control the expulsion of gas from an exhaust port of the cylinder. The method includes the steps of: cranking the engine, conditioning intake air at the intake port of the cylinder to raise the temperature of air in the cylinder, controlling a valve timing the intake valve and/or the exhaust valve to allow the piston to compress the air within the cylinder, thereby increasing the temperature of the air within the cylinder, and injecting fuel into the cylinder when the air within the cylinder has been heated to a temperature sufficient to support compression ignition of a gasoline and air mixture within the cylinder.
Creating a training set for artificial intelligence from initial segmentations of airways (2021)

Airways segmentation is important for research about pulmonary disease but require a large amount of time by trained specialists. We used an openly available software to improve airways segmentations obtained from an artificial intelligence (AI) tool and retrained the tool to get a better performance. Fifteen initial airway segmentations from low-dose chest computed tomography scans were obtained with a 3D-Unet AI tool previously trained on Danish Lung Cancer Screening Trial and Erasmus-MC Sophia datasets. Segmentations were manually corrected in 3D Slicer. The corrected airway segmentations were used to retrain the 3D-Unet. Airway measurements were automatically obtained and included count, airway length and luminal diameter per generation from the segmentations. Correcting segmentations required 2-4 h per scan. Manually corrected segmentations had more branches (p < 0.001), longer airways (p < 0.001) and smaller luminal diameters (p = 0.004) than initial segmentations. Segmentations from retrained 3D-Unets trended towards more branches and longer airways compared to the initial segmentations. The largest changes were seen in airways from 6th generation onwards. Manual correction results in significantly improved segmentations and is potentially a useful and time-efficient method to improve the AI tool performance on a specific hospital or research dataset.
Application of Ultrasonic Test System for Test Performance Improvement of Welding Flaw (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
ChemInform Abstract: Carbon Dioxide as a Raw Material: The Synthesis of Formic Acid and Its Derivatives from CO2 (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
N-polar GaN HEMTs with f<inf>max</inf> &#x003E; 300 GHz using high-aspect-ratio T-gate design (2011)

In this paper, we report measured f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</sub> data of over 300 GHz on an MOCVD-grown N-polar GaN HEMT using a high-aspect-ratio T-gate. To our knowledge, this >; 300-GHz f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</sub> value is the highest reported to date for N-polar GaN HEMTs and is 50% higher than the previously reported value (Nidhi et al., 2010).
Measurement of oxygen consumption in Tenebrio molitor using a sensitive, inexpensive, sensor-based coulometric microrespirometer (2022)

Coulometric respirometry is a highly sensitive method for measuring O2 consumption in small organisms but it is not in widespread use among physiologists. Here, we describe a coulometric microrespirometer based on a digital environmental sensor inside a sealed glass chamber and controlled by an Arduino™ microcontroller. As O2 is consumed, exhaled CO2 is removed, causing pressure to decrease in the chamber. The sensor detects the decreased pressure, and the controller activates electrolytic production of O2, returning pressure to the initial value. O2 consumption is calculated from electrolytic charge transfer. The effects of developmental stage, body mass and temperature on O2 consumption of Tenebrio molitor beetles were easily measured by the apparatus. This straightforward design is a significant innovation in that it provides continuous data regarding environmental conditions inside the experimental chamber, can be fabricated easily, and is adaptable to a wide range of uses.
New LTCC materials: From fundamental to applied research (2012)

Over the last twenty years, low-temperature co-firing ceramic (LTCC) technology has advanced to such an extent that it now allows the integration of a variety of passive components within the LTCC module. However, to achieve better performance some of them are still mounted as discrete components on the top of the module. An example of this type of component is a capacitor. In principle, no technological or design obstacles exist that would prevent the integration of capacitors into the module. The only problem is a lack of suitable LTCC material that exhibits the proper dielectric characteristics and is compatible with current LTCC materials and technology. Because the NP0-type capacitors represent the largest group of capacitors used with LTCC modules for RF applications we started the development of an NP0-type ceramic layer suitable for direct implementation with existing LTCC production lines. In this talk an example of such development will be presented where the very fundamental research has successfully been upgraded with an applied research and the new functional LTCC layers have been developed. They are characterized by K80, temperature stability, low dielectric loss and cosinterability with commercial low K tapes and silver electrode. The review of all the material properties relevant for the existing LTCC technology shows the possibility of a direct integration of the developed NP0-capacitor layer into the current LTCC modules.
ACS Chemical Neuroscience Molecule Spotlight on RG1678 (2011)

RG1678 is a glycine transporter-1 inhibitor currently in Phase III trials for the treatment of the negative symptoms of schizophrenia and is being developed by Roche (in combination with Chugai). Recent Phase II data shows that RG1678 is effective in reducing the negative symptoms when given in combination with second generation antipsychotics.
Analyse quantitative de plasmons de surface localisés basée sur une approche photochimique (2010)

International audience
pH measurement in human skeletal muscle samples: effect of phosphagen hydrolysis (1986)

Measurements of muscle pH (pHm) with the homogenate technique are routinely made when extensive phosphagen hydrolysis has occurred. Upon exposure of the homogenate to 37 degrees C in the pH meter, phosphocreatine and ATP were rapidly degraded to 35 and 60% of control concentrations after 30 s. Attempts at chemically arresting this hydrolysis were unsuccessful. Therefore we examined the significance of phosphagen hydrolysis on pHm measurement in human biopsies taken at rest and following intense electrical stimulation. To accomplish this, pHm was measured at 0 degree C, where extensive hydrolysis did not occur. On the same homogenate, pHm was measured at 0 degree C with phosphagens and at 0 and 37 degrees C after phosphagen hydrolysis. The effect of phosphagen hydrolysis on pHm at 0 degrees C was used to estimate this effect at 37 degrees C. In resting samples, phosphagen hydrolysis produced a nonsignificant acidification of 0.008 pH units and, in electrically stimulated samples, a nonsignificant alkalinization of 0.033 units. Measurements of homogenate PCO2 suggested that most of the CO2 remained in the sample during pHm measurement at 37 degrees C. The present work substantiates the use of the homogenate technique as an accurate and practical method for the estimation of intracellular pH in resting and exercise human muscle samples.
A minority-group of renal cell cancer patients with high infiltration of CD20+B-cells is associated with poor prognosis (2018)

This exploratory study identifies a previously unrecognised poor-prognosis subset of RCC with high density of CD20-defined B-cells.
I4U Submission to NIST SRE 2018: Leveraging from a Decade of Shared Experiences (2019)

The I4U consortium was established to facilitate a joint entry to NIST speaker recognition evaluations (SRE). The latest edition of such joint submission was in SRE 2018, in which the I4U submission was among the best-performing systems. SRE'18 also marks the 10-year anniversary of I4U consortium into NIST SRE series of evaluation. The primary objective of the current paper is to summarize the results and lessons learned based on the twelve sub-systems and their fusion submitted to SRE'18. It is also our intention to present a shared view on the advancements, progresses, and major paradigm shifts that we have witnessed as an SRE participant in the past decade from SRE'08 to SRE'18. In this regard, we have seen, among others, a paradigm shift from supervector representation to deep speaker embedding, and a switch of research challenge from channel compensation to domain adaptation.
The tailless Ortholog nhr-67 Regulates Patterning of Gene Expression and Morphogenesis in the C. elegans Vulva (2007)

Regulation of spatio-temporal gene expression in diverse cell and tissue types is a critical aspect of development. Progression through Caenorhabditis elegans vulval development leads to the generation of seven distinct vulval cell types (vulA, vulB1, vulB2, vulC, vulD, vulE, and vulF), each with its own unique gene expression profile. The mechanisms that establish the precise spatial patterning of these mature cell types are largely unknown. Dissection of the gene regulatory networks involved in vulval patterning and differentiation would help us understand how cells generate a spatially defined pattern of cell fates during organogenesis. We disrupted the activity of 508 transcription factors via RNAi and assayed the expression of ceh-2, a marker for vulB fate during the L4 stage. From this screen, we identified the tailless ortholog nhr-67 as a novel regulator of gene expression in multiple vulval cell types. We find that one way in which nhr-67 maintains cell identity is by restricting inappropriate cell fusion events in specific vulval cells, namely vulE and vulF. nhr-67 exhibits a dynamic expression pattern in the vulval cells and interacts with three other transcriptional regulators cog-1 (Nkx6.1/6.2), lin-11 (LIM), and egl-38 (Pax2/5/8) to generate the composite expression patterns of their downstream targets. We provide evidence that egl-38 regulates gene expression in vulB1, vulC, vulD, vulE, as well as vulF cells. We demonstrate that the pairwise interactions between these regulatory genes are complex and vary among the seven cell types. We also discovered a striking regulatory circuit that affects a subset of the vulval lineages: cog-1 and nhr-67 inhibit both one another and themselves. We postulate that the differential levels and combinatorial patterns of lin-11, cog-1, and nhr-67 expression are a part of a regulatory code for the mature vulval cell types.
Use of Gonadotropin- Releasing Hormone Agonist to Cause Ovulation and Prevent the Ovarian Hyperstimulation Syndrome (1993)

The physiologic basis and clinical applications of the use of GnRHa, rather than hCG, to induce the final stage of oocyte maturation and ovulation in gonadotropin-treated cycles were reviewed. A single mid-cycle dose of GnRHa is able to trigger a preovulatory LH/FSH surge, leading to oocyte maturation and pregnancy in women undergoing ovarian stimulation for IVF/ET or induction of ovulation in vivo. The limited information currently available suggests there are similar pregnancy rates in patients treated with either GnRHa or hCG. The potential clinical advantages of GnRHa over hCG in gonadotropin-treated cycles include 1) the ability to titrate the amplitude and duration of the LH surge, 2) better control of luteal steroid hormone levels, 3) a higher implantation rate, 4) a lower rate of multiple pregnancy, and 5) a reduced risk of OHS. To date, the GnRHa regimen has been effective in preventing OHS in patients at high risk for having this complication.
C14 Combinatorial Methods in Catalysis Research: High Speed Characterization and Testing of Materials — Invited (2003)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Identification and Differentiation of Highly Diverse Campylobacter concisus Strains using the MALDI Biotyper (2016)

Campylobacter jejuni is the most commonly reported bacteriological agent in infectious gastrointestinal disease However, in a population-based study of diarrheic stool samples in North Denmark Region, with a population of 580,000 inhabitants In a questionnaire study, C. concisus-positive patients reported a milder, though more prolonged diarrhoea than did patients with C. jejuni Furthermore, recent studies have linked C. concisus with inflammatory bowel diseases, since a high prevalence of C. concisus DNA has been detected in colonic biopsies of patients with Crohn's disease compared to controls Furthermore, in-vitro studies have shown that C. concisus is capable of invading intestinal epithelial cells, where it may increase apoptosis and the intestinal permeability These findings support the understanding of C. concisus as an intestinal pathogen. Campylobacter jejuni and other Campylobacter species can easily be identified to species level with use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) Campylobacter concisus does not grow on modified charcoal-cefoperazone-deoxycholate agar (mCCDA) which is routinely used for cultivation mCCDA in western countries. However, Campylobacter concisus and other emerging Campylobacter species can be isolated in high numbers in stools by use of a filtration technique on 5% yeast-enriched blood agar plates (SSI Diagnostica, Hillerd, Denmark) incubated at 37C in a microaerobic atmosphere with hydrogen Identification of C. concisus has until recently been based on PCR-based techniques which may seem slow compared to the rapid identification by use of the MALDI-TOF MS. In this study, we evaluated MALDI-TOF MS as a method for the rapid identification of C. concisus.
Effects of simulated oxidation on thein vitrowear and mechanical properties of irradiated and melted highly crosslinked UHMWPE (2015)

Radiation crosslinked ultrahigh molecular weight polyethylene (UHMWPE) have reduced the wear rate of the bearing surface in total joint arthroplasty and the incidence of peri-prosthetic bone loss due to wear particles. The oxidation potential afforded to the material by the trapped residual free radicals after irradiation was addressed in first generation crosslinked UHMWPEs by using thermal treatments such as annealing or melting after irradiation. Postirradiation melted crosslinked UHMWPE did not contain detectable free radicals at the time of implantation and was expected to be resistant against oxidation for the lifetime of the implants. Recent analyses of long-term retrievals showed it was possible for irradiated and melted UHMWPEs to oxidize in vivo but studies on the effects of oxidation on these materials have been limited. In this study, we determined the effects of in vitro aging on the wear and mechanical properties of irradiated and melted UHMWPE as a function of radiation dose and found that even small amount of oxidation (oxidation index of 0.1) can have detrimental effects on its mechanical properties. There was a gradual increase in the wear rate below an oxidation index of 1 and a drastic increase thereafter. Therefore, it was shown in a simulated environment that oxidation can have detrimental effects to the clinically relevant properties of irradiated and melted UHMWPEs.
Erythrocyte rosettes--a marker for bovine T cells. (1976)

In this paper we describe how rolling stock and passenger connections in a cyclic railway timetable can be modeled in a flexible way within the model for the Periodic Event-Scheduling Problem (PESP). Usually, PESP models assume that the constraints for rolling stock or passenger connections specify in detail which trains should connect with each other. However, the flexibility described in this paper allows the model to choose which trains should connect with each other in a rolling stock or passenger connection. We express the connection times in a minimum matching of arriving and departing trains in terms of certain process time variables. We also describe an abstract framework demonstrating that, under certain conditions, the extra flexibility can be modeled purely in terms of PESP constraints. The concept of flexible rolling stock and passenger connections is illustrated by an example based on three intercity lines of Netherlands Railways.
ChemInform Abstract: Structural Investigations of Glycoconjugates at High Sensitivity (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Array enhanced stochastic resonance: Implications for signal processing (1996)

In computer simulations, we enhance the response of a ‘‘stochastic resonator’’ by coupling it into an array of identical resonators. We relate this array enhanced stochastic resonance (AESR) to the global spatiotemporal dynamics of the array and show how noise and coupling cooperate to organize spatial order, temporal periodicity, and peak output signal‐to‐noise ratio. We consider the application of AESR to signal processing.
Molecular Characterization of Oxysterol Binding to the Epstein-Barr Virus-induced Gene 2 (GPR183) (2012)

Oxysterols are oxygenated cholesterol derivates that are emerging as a physiologically important group of molecules. Although they regulate a range of cellular processes, only few oxysterol-binding effector proteins have been identified, and the knowledge of their binding mode is limited. Recently, the family of G protein-coupled seven transmembrane-spanning receptors (7TM receptors) was added to this group. Specifically, the Epstein-Barr virus-induced gene 2 (EBI2 or GPR183) was shown to be activated by several oxysterols, most potently by 7α,25-dihydroxycholesterol (7α,25-OHC). Nothing is known about the binding mode, however. Using mutational analysis, we identify here four key residues for 7α,25-OHC binding: Arg-87 in TM-II (position II:20/2.60), Tyr-112 and Tyr-116 (positions III:09/3.33 and III:13/3.37) in TM-III, and Tyr-260 in TM-VI (position VI:16/6.51). Substituting these residues with Ala and/or Phe results in a severe decrease in agonist binding and receptor activation. Docking simulations suggest that Tyr-116 interacts with the 3β-OH group in the agonist, Tyr-260 with the 7α-OH group, and Arg-87, either directly or indirectly, with the 25-OH group, although nearby residues likely also contribute. In addition, Tyr-112 is involved in 7α,25-OHC binding but via hydrophobic interactions. Finally, we show that II:20/2.60 constitutes an important residue for ligand binding in receptors carrying a positively charged residue at this position. This group is dominated by lipid- and nucleotide-activated receptors, here exemplified by the CysLTs, P2Y12, and P2Y14. In conclusion, we present the first molecular characterization of oxysterol binding to a 7TM receptor and identify position II:20/2.60 as a generally important residue for ligand binding in certain 7TM receptors.
LiNbO/sub 3/ optical single-sideband modulator (2002)

An LiNbO/sub 3/ SSB modulator was fabricated by integrating four phase-modulator waveguides, an asymmetric cross junction, and a sideband-suppression gate. The demonstration of the SSB modulation and the expectation of future applications are described.
Developing a Forward Collision Warning System Timing and Interface Approach by Placing Drivers in Realistic Rear-End Crash Situations (2000)

Forward Collision Warning (FCW) systems are intended to reduce the harm caused by rear-end crashes. As part of the GM-Ford Crash Avoidance Metrics Partnership FCW project, four closed-course studies were conducted. These studies were focused on defining when to present FCW system crash alerts to drivers (i.e., the crash alert timing approach) and how to present FCW system crash alerts to drivers (i.e., visual, auditory, and/or haptic alerts). This project developed a “surrogate target” methodology which allowed experimenters to safely place inattentive drivers in realistic, “surprise” rear-end crash scenarios and observe their behavior. Results from these studies provided support for the deceleration-based crash alert timing approach developed, and support coupling the visual and non-speech tone alert components evaluated for FCW system implementation.
Multi-dimensional Evaluation of Haswell's Transactional Memory Performance (2014)

This paper presents an extensive performance study of the implementation of Hardware Transactional Memory (HTM) in the Haswell generation of Intel x86 core processors. This study evaluates the strengths and weaknesses of this new architecture exploring several dimensions in the space of Transactional Memory (TM) application characteristics using the Eigenbench [1] and the CLOMP-TM [2] benchmarks. This detailed performance study provides insights on the constraints imposed by the Intel's Transaction Synchronization Extension (Intel's TSX) and introduces a simple, but efficient policy for guaranteeing forward progress on top of the besteffort Intel's HTM and also was critical to achieving performance. The evaluation also shows that there are a number of potential improvements for designers of TM applications and software systems that use Intel's TM and provides recommendations to extract maximum benefit from the current TM support available in Haswell.