gebhart/patrepeval huggingface dataset:
Immune alterations during SARS-CoV-2-related acute respiratory distress syndrome (2020)

Abstract We report a longitudinal analysis of the immune response associated with a fatal case of COVID-19. This patient exhibited a rapid evolution towards multiorgan failure. SARS-CoV-2 was detected in multiple nasopharyngeal, blood, and pleural samples, despite antiviral and immunomodulator treatment. Clinical evolution in the blood was marked by an increase (2-3 fold) in differentiated effector T cells expressing exhaustion (PD-1) and senescence (CD57) markers, an expansion of antibody-secreting cells, a 15-fold increase in γδ T-cell and proliferating NK-cell populations, and the total disappearance of monocytes, suggesting lung trafficking. In the serum, waves of a proinflammatory cytokine storm, Th1 and Th2 activation, and markers of T-cell exhaustion, apoptosis, cell cytotoxicity, and endothelial activation were observed until the fatal outcome. This case underscores the need for well-designed studies to investigate complementary approaches to control viral replication, the source of the hyperinflammatory status, and immunomodulation to target the pathophysiological response.
Benzimidazoles as New Potent and Selective DP Antagonists for the Treatment of Allergic Rhinitis. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Dual-frequency liquid crystal gels with submillisecond response time (2004)

Two types of gels using dual-frequency liquid crystal are demonstrated. The one using a homogeneous cell shows anisotropic scattering behavior while the other prepared using a cell without polyimide alignment layers exhibits isotropic scattering properties. Both liquid crystal gels are highly transparent in the voltage-off state. Light scattering occurs when a high frequency voltage is applied. The isotropic gel exhibits a high contrast ratio and submillisecond response time. Potential applications of these gels for switchable polarizer, telecom optical switch, and reflective displays are emphasized.
Asymptotic Analysis of SU-MIMO Channels With Transmitter Noise and Mismatched Joint Decoding (2014)

Hardware impairments in radio-frequency components of a wireless system cause unavoidable distortions to transmission that are not captured by the conventional linear channel model. In this paper, a “binoisy” single-user multiple-input multiple-output (SU-MIMO) relation is considered where the additional distortions are modeled via an additive noise term at the transmit side. Through this extended SU-MIMO channel model, the effects of transceiver hardware impairments on the achievable rate of multi-antenna point-to-point systems are studied. Channel input distributions encompassing practical discrete modulation schemes, such as, QAM and PSK, as well as Gaussian signaling are covered. In addition, the impact of mismatched detection and decoding when the receiver has insufficient information about the non-idealities is investigated. The numerical results show that for realistic system parameters, the effects of transmit-side noise and mismatched decoding become significant only at high modulation orders.
A Smartphone-Based Near-Vision Testing System: Design, Accuracy, and Reproducibility Compared With Standard Clinical Measures (2022)

Smartphone-based VA and contrast sensitivity are highly correlated with standard charts and may be useful in augmenting limited inoffice care. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i>. 2022;53:79-84.]</b>.
118 Functional Properties of Bifidobacterium Animalis Subsp. Lactis Cect 8145 in Canine Nutrition (2022)

Abstract The gut bacterial population has been demonstrated to influence the physiologic and metabolic functions of the host by modulating energy expenditure and immune response, therefore contributing to the health of the host. However, there is little information regarding the effects of probiotics and postbiotics on canine nutrition. The objective of this study was to evaluate the longitudinal effects of daily supplementation of Bifidobacterium animalis subsp. lactis CECT 8145 and the same strain in a heat-killed presentation (postbiotic) on weight management, fecal fermentative end-product concentration, gut hormones, postprandial glycemic and insulinemic response in overweight dogs. Thirty-six adult dogs were used in a completely randomized, double-blinded, placebo-controlled study, with 12 animals per treatment. Dogs were fed a commercial dry extruded complete and balanced diet twice daily to maintain body weight. Following a 60 d adaptation to the control diet, dogs were fed their respective treatment diets for 90 d. Treatments were provided by ADM Biopolis (Valencia, Spain) and given via gelatin capsules before morning feeding to ensure consumption of the total dose of their placebo, probiotic, or heat-killed probiotic. The treatments supplementation had no detrimental effect on the overall dog's health. Throughout the experimental period, fecal scores did not differ among dogs fed different dietary treatments (P &amp;gt; 0.05). However, fecal pH was significantly lower (P = 0.0049) in the dogs fed the postbiotic (5.8) compared with the group control (6.1). Greater fecal concentration of propionate (P=0.0427) was observed on dogs fed the probiotic and the dogs fed the postbiotic compared with the group control. Pancreatic polypeptide plasma concentration was less (P &amp;lt; 0.05) in the dogs fed the probiotic compared with treatment control. These data suggest that the longitudinal supplementation of this specific strain in the live and heat-killed presentation may interact with gut microbial fermentation and gut hormonal regulation.
Preface (1996)

ADVERTISEMENT RETURN TO BOOKPREVPrefaceNEXTPrefaceJAMES L. HEDRICKJAMES L. HEDRICKIBM Almaden Research Center 650 Harry Road San Jose, CA 95120-6099More by JAMES L. HEDRICK and JEFF W. LABADIEJEFF W. LABADIEArgonaut Technologies, Inc. 887 Industrial Road San Carlos, CA 94070-3305More by JEFF W. LABADIEDOI: 10.1021/bk-1996-0624.pr001 This publication is free to access through this site. Learn MorePublication Date (Print):May 5, 1996Publication History Published online23 July 2009Published inprint 5 May 1996Request reuse permissions Copyright © 1996 American Chemical Society. This publication is available under these Terms of Use. Step-Growth Polymers for High-Performance Materialspp ix-xACS Symposium SeriesVol. 624ISBN13: 9780841233942eISBN: 9780841215733Chapter Views159Citations-LEARN ABOUT THESE METRICSChapter Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (200 KB) Get e-Alerts
Behavior of Double Emulsions in a Cross-Type Optical Separation System (2012)

The behavior of double emulsions in a cross-type optical particle separation system was studied for different combinations of refractive indices and different inner and outer layer radii. The radii and refractive indices of the double emulsions were easily adjusted by taking advantage of the coflowing geometry of a cross-type optical particle separation device. An analytical expression of the optical forces on a pair of concentric spheres was derived using the photon stream method in the ray optics regime. The predicted trajectories of the double emulsions by the optical force agreed well with the experimental data. This work has potential uses in cell separation by morphometry, drug delivery vehicle, and emulsion-based biomedical applications.
Actuator-Control Circuit Based on OTFTs and Flow-Rate Estimation for an All-Organic Fluid Pump (2016)

In this paper, we report the design of an organic thin-film transistor (OTFT) driver circuit for the actuator of an organic fluid pump, which can be integrated in a portable-size fully-organic artificial lung. Compared to traditional pump designs, lightness, compactness and scalability are achieved by adopting a creative pumping mechanism with a completely organic-material-based system concept. The transportable fluid volume is verified to be flexibly adjustable, enabling on-demand controllability and scalability of the pump's fluid-flow rate. The simulations, based on an accurate surface-potential OTFT compact model, demonstrate that the necessary driving waveforms can be efficiently generated and adjusted to the actuator requirements. At the actuator-driving-circuit frequency of 0.98Hz, an all-organic fluid pump with 40cm length and 0.2cm height is able to achieve a flow rate of 0.847L/min, which satisfies the requirements for artificial-lung assist systems to a weakened normal lung.
Finite element analysis of gradient coil deformation and vibration in NMR microscopy (1992)

Resolution degradation due to gradient coil deformation and vibration in NMR microscopy is investigated using finite element analysis. From the analysis, deformations due to the Lorentz force can be as large as 1-10 mum depending on the gradient strength and coil frame material. Thus, these deformations can be one of the major resolution limiting factors in NMR microscopy. Coil vibration, which depends on the input current waveform and resolution degradation due to time-variant deformation and time-invariant deformation are investigated by numerical simulations.
Max-min fairness based radio resource management in fourth generation heterogeneous networks (2009)

In the heterogeneous networks, radio resource management (RRM) plays an important role to utilize the potential network diversity. In this paper, we study the RRM strategy in the heterogeneous networks involved with an orthogonal frequency division multiple access (OFDMA) network, with the aim of maximizing the minimum user throughput. An analytical model which reflects the feature of heterogeneous networks is presented in order to formulate the RRM problem. Assuming that the system can support multi-homing access and the subcarrier can be shared by multiple users in the OFDMA network, the problem can be formulated by a convex optimization problem and the optimal solution is obtained. We also propose a suboptimal RRM algorithm for practical applications, including network selection and resource allocation in each network. The performance of the proposed RRM algorithms is evaluated in the heterogeneous long term evolution (LTE)-wireless local area network (WLAN) networks. Our simulation results show considerable gains in comparison to the performance of LTE-Only and WLAN-First strategies. In addition, the performance gap between the optimal solution and suboptimal algorithm becomes minor as the number of users increases.
Supplemental figure 7 & 8 from Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies (2023)

&lt;p&gt;BET inhibitor causes cell cycle arrest and triggers senescence in solid tumor cells&lt;/p&gt;
Sequestration of TDP-43 216-414 Aggregates by Cytoplasmic Expression of the proSAAS Chaperone (2022)

As neurons age, protein homeostasis becomes less efficient, resulting in misfolding and aggregation. Chaperone proteins perform vital functions in the maintenance of cellular proteostasis, and chaperone-based therapies that promote sequestration of toxic aggregates may prove useful in blocking the development of neurodegenerative disease. We previously demonstrated that proSAAS, a small secreted neuronal protein, exhibits potent chaperone activity against protein aggregation in vitro and blocks the cytotoxic effects of amyloid and synuclein oligomers in cell culture systems. We now examine whether cytoplasmic expression of proSAAS results in interactions with protein aggregates in this cellular compartment. We report that expression of proSAAS within the cytoplasm generates dense, membraneless 2 μm proSAAS spheres which progressively fuse to form larger spheres, suggesting liquid droplet-like properties. ProSAAS spheres selectively accumulate a C-terminally truncated fluorescently tagged form of TDP-43, initiating its cellular redistribution; these TDP-43-containing spheres also exhibit dynamic fusion. Efficient encapsulation of TDP-43 into proSAAS spheres is driven by its C-terminal prion-like domain; spheres must be formed for sequestration to occur. Three proSAAS sequences, a predicted coiled-coil, a conserved region (residues 158-169), and the positively charged sequence 181-185, are all required for proSAAS to form spheres able to encapsulate TDP-43 aggregates. Substitution of lysines for arginines in the 181-185 sequence results in nuclear translocation of proSAAS and encapsulation of nuclear-localized TDP-43<sup>216-414</sup>. As a functional output, we demonstrate that proSAAS expression results in cytoprotection against full-length TDP-43 toxicity in yeast. We conclude that proSAAS can act as a functional holdase for TDP-43 via this phase-separation property, representing a cytoprotectant whose unusual biochemical properties can potentially be exploited in the design of therapeutic molecules.
Re-useable hardware/software co-verification of IP blocks (2002)

A novel use of remote procedure call techniques gives access to the software driver API of an IP block from a high-level verification testbench. This allows an IP block to be validated through its software interface as well as its hardware interface. Such a unified methodology has immediate benefits for IP block development. More importantly, it allows re-useable, system level verification components to be produced, which greatly enhance the value of an IP block. A combination of commercial testbench and co-simulation tools is used to demonstrate this methodology.
Matrix Extension for Pathological Radar Clutter Machine Learning (2020)

This paper deals with radar clutter statistical learning based on spatial Doppler fluctuation. In articles [1]-[4], data is clustered cell by cell. In this article, we generalize the previous model to extract information not only from each cell independently, but also from the cells spatial correlation. We first introduce the radar data, then the model and efficient tools to estimate the model parameters. The model parameters will be shown to be Hermitian Positive Definite Block-Toeplitz matrices. Next we endow the manifold of Hermitian Positive Definite Block-Toeplitz matrices with a Riemannian metric coming from information geometry. Finally, we adapt a supervised classification algorithm (the k-Nearest Neighbors) and an unsupervised classification algorithm (the Agglomerative Hierarchical Clustering) to this Riemannian manifold.
Diagnostic biomarkers of prostate cancer (2010)

AMACR is an accurate diagnostic tissue marker for PC. However, in some PCs AMACR is false negative and a panel of CYCS, ICK and IKBKB may serve as ancillary diagnostic tool.
Power Grid Reliability: Implications of Environmental Regulation and Coal Plant Retirement in Systems with Large Scale Penetration of Wind Power (2015)

The Environmental Protection Agency’s (EPA) regulations and the Renewable Portfolio Standards (RPS) have provoked a prolonged debate on the electricity system reliability. EPA will likely result in the retirement of coal power plants while the state RPSs will continue drive large-scale deployment of the renewable energy sources, primarily wind. Combined, these changes in the generation fleet may affect the reliable operations of the power system, as coal plants are well-suited to balance the low frequency variability of wind. In order to understand the real implications of these alterations, we extensively analyze the operations of the PJM electricity system under different wind penetration and coal plant retirement scenarios. For this purpose, we use a security constrained unit commitment (SCUC) to model the grid’s ability in providing and transferring least cost energy to the consumers. We evaluate several metrics including electricity prices, unserved energy, transmission congestion levels, wind curtailment level, coal and wind share in the total generation for each study scenario.
Characterization of aJAZ7activation-tagged Arabidopsis mutant with increased susceptibility to the fungal pathogenFusarium oxysporum (2016)

In Arabidopsis, jasmonate (JA)-signaling plays a key role in mediating Fusarium oxysporum disease outcome. However, the roles of JASMONATE ZIM-domain (JAZ) proteins that repress JA-signaling have not been characterized in host resistance or susceptibility to this pathogen. Here, we found most JAZ genes are induced following F. oxysporum challenge, and screening T-DNA insertion lines in Arabidopsis JAZ family members identified a highly disease-susceptible JAZ7 mutant (jaz7-1D). This mutant exhibited constitutive JAZ7 expression and conferred increased JA-sensitivity, suggesting activation of JA-signaling. Unlike jaz7 loss-of-function alleles, jaz7-1D also had enhanced JA-responsive gene expression, altered development and increased susceptibility to the bacterial pathogen PstDC3000 that also disrupts host JA-responses. We also demonstrate that JAZ7 interacts with transcription factors functioning as activators (MYC3, MYC4) or repressors (JAM1) of JA-signaling and contains a functional EAR repressor motif mediating transcriptional repression via the co-repressor TOPLESS (TPL). We propose through direct TPL recruitment, in wild-type plants JAZ7 functions as a repressor within the JA-response network and that in jaz7-1D plants, misregulated ectopic JAZ7 expression hyper-activates JA-signaling in part by disturbing finely-tuned COI1-JAZ-TPL-TF complexes.
Anisotropy of Charge Transport in a Uniaxially Aligned and Chain‐Extended, High‐Mobility, Conjugated Polymer Semiconductor (2011)

Abstract Charge transport in the ribbon phase of poly(2,5‐bis(3‐alkylthiophen‐2‐yl)thieno[3,2‐ b ]thiophene) (PBTTT)—one of the most highly ordered, chain‐extended crystalline microstructures available in a conjugated polymer semiconductor—is studied. Ribbon‐phase PBTTT has previously been found not to exhibit high carrier mobilities, but it is shown here that field‐effect mobilities depend strongly on the device architecture and active interface. When devices are constructed such that the ribbon‐phase films are in contact with either a polymer gate dielectric or an SiO 2 gate dielectric modified by a hydrophobic, self‐assembled monolayer, high mobilities of up to 0.4 cm 2 V −1 s −1 can be achieved, which is comparable to those observed previously in terrace‐phase PBTTT. In uniaxially aligned, zone‐cast films of ribbon‐phase PBTTT the mobility anisotropy is measured for transport both parallel and perpendicular to the polymer chain direction. The mobility anisotropy is relatively small, with the mobility along the polymer chain direction being higher by a factor of 3–5, consistent with the grain size encountered in the two transport directions.
Increased fairness in cellular networks through baste station cooperation (2009)

The inherent trade-off between maximizing the overall throughput and achieving user fairness in cellular networks is well known. This trade-off does not only affect the choice of scheduling objective, but is also relevant for other system design choices. In this paper we extend the standard sum throughput to a family of metrics placing varying emphasis on fairness. We use the proposed metric both for performance evaluation and as a tool for optimization of user scheduling. We then propose a base station coordination scheme targeted primarily for cell edge users. Specifically we allow two neighboring base stations to serve a single user opportunistically by coherent transmit combining. The proposed strategy shows significant performance gains using ldquofairness-rewardingrdquo metrics.
Cancer Chemoprevention: Selective Inhibition of Cytochrome P450 2A13 (2009)

4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) is one of the most prevalent and carcinogenic compounds in tobacco. NNK is selectively activated by human cytochrome P450 2A13 (CYP2A13) to form two carcinogens that generate DNA adducts. CYP2A13 is found in the respiratory tract where NNK‐derived adducts can result in lung cancer. CYP2A13 is 93.5% identical to the hepatic cytochrome P450 2A6 (CYP2A6), which does not efficiently metabolize NNK but does metabolize other xenobiotic compounds. Thus a selective inhibitor of CYP2A13 could be used as a chemopreventative for tobacco users. High throughput screening was used to identify small molecule scaffolds that selectively bound CYP2A13 over CYP2A6. One such scaffold was benzylmorpholine. A small library of benzylmorpholine analogs was generated and has been evaluated for differential ligand binding (K d ) and inhibition of human cytochrome P450 2A enzymes. Examination of these results is revealing selective compounds that could be used for the reduction of lung cancer related to DNA damage in tobacco users.
Video rate nine-band multispectral short-wave infrared sensor (2014)

Short-wave infrared (SWIR) imaging sensors are increasingly being used in surveillance and reconnaissance systems due to the reduced scatter in haze and the spectral response of materials over this wavelength range. Typically SWIR images have been provided either as full motion video from framing panchromatic systems or as spectral data cubes from line-scanning hyperspectral or multispectral systems. Here, we describe and characterize a system that bridges this divide, providing nine-band spectral images at 30 Hz. The system integrates a custom array of filters onto a commercial SWIR InGaAs array. We measure the filter placement and spectral response. We demonstrate a simple simulation technique to facilitate optimization of band selection for future sensors.
Future Scenarios for Local Area Access: Industry Structure and Access Fragmentation (2009)

Indoor deployments of wireless access points will likely be required to fulfill the future traffic capacity requirements. Considerable uncertainty exists, however, about the technologies utilized to provide local area access, as well as the roles of different actors in the value network providing mobile services. We apply Schoemakerpsilas scenario planning method to identify and analyze the key uncertainties and to construct four alternative and plausible future scenarios having different implications to local area access technologies and business models. The results are valuable in designing wireless technologies and standards for the future, as well as in pointing out the role of local area access provisioning as a potential control point in the mobile services business.
A Vision-Based Control and Interaction Framework for a Legged Underwater Robot (2009)

We present a vision-based control and interaction framework for mobile robots, and describe its implementation in a legged amphibious robot. The control scheme enables the robot to navigate, follow targets of interest, and interact with human operators. The visual framework presented in this paper enables deployment of the vehicle in underwater environments along with a human scuba diver as the operator, without requiring any external tethered control. We present the current implementation of this framework in our particular family of underwater robots, with a focus on the underlying software and hardware infrastructure. We look at the practical issues pertaining to system implementation as it applies to our framework, from choice of operating systems to communication bus design. While our system has been effectively used in both open-ocean andclosed-water environments, we perform some quantitative measurements with an effort to analyze the responsiveness and robustness of the complete architecture.