gebhart/patrepeval huggingface dataset:
Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer (2017)

Albendazole is an anti-helminthic drug that has been shown to exhibit anti-cancer properties, however its activity in head and neck squamous cell cancer (HNSCC) was unknown. Using a series of <i>in vitro</i> assays, we assessed the ability of albendazole to inhibit proliferation in 20 HNSCC cell lines across a range of albendazole doses (1 nM-10 μM). Cell lines that responded to treatment were further examined for cell death, inhibition of migration and cell cycle arrest. Thirteen of fourteen human papillomavirus-negative HNSCC cell lines responded to albendazole, with an average IC<sub>50</sub> of 152 nM. In contrast, only 3 of 6 human papillomavirus-positive HNSCC cell lines responded. Albendazole treatment resulted in apoptosis, inhibition of cell migration, cell cycle arrest in the G2/M phase and altered tubulin distribution. Normal control cells were not measurably affected by any dose tested. This study indicates that albendazole acts to inhibit the proliferation of human papillomavirus-negative HNSCC cell lines and thus warrants further study as a potential chemotherapeutic agent for patients suffering from head and neck cancer.
Direct nuclear-pumped laser approaching feedback laser fusion needs (1977)

A new direct nuclear pumped laser in which the lasing output is delayed for relatively long times (milliseconds) with respect to nuclear excitation is described. The laser operates at 1.45 ..mu.. in gas mixtures of He-CO and He-CO/sub 2/. The nuclear pumping process is described. (MOW)
Advances in Subcritical Hydro‐/Solvothermal Processing of Graphene Materials (2017)

Many promising graphene-based materials are kept away from mainstream applications due to problems of scalability and environmental concerns in their processing. Hydro-/solvothermal techniques overwhelmingly satisfy both the aforementioned criteria, and have matured as alternatives to wet-chemical methods with advances made over the past few decades. The insolubility of graphene in many solvents poses considerable difficulties in their processing. In this context hydro-/solvothermal techniques present an ideal opportunity for processing of graphenic materials with their versatility in manipulating the physical and thermodynamic properties of the solvent. The flexibility in hydro-/solvothermal techniques for manipulation of solvent composition, temperature and pressure provides numerous handles to manipulate graphene-based materials during synthesis. This review provides a comprehensive look at the subcritical hydro-/solvothermal synthesis of graphene-based functional materials and their applications. Several key synthetic strategies governing the morphology and properties of the products such as temperature, pressure, and solvent effects are elaborated. Advances in the synthesis, doping, and functionalization of graphene in hydro-/solvothermal media are highlighted together with our perspectives in the field.
Automatic Evaluation of Fluency in Spoken Language (2009)

AbstractThis paper introduces the problem of automatic evaluation of spoken language fluency, and reviews some techniques proposed in the literature to solve it. In the first section, the need for automatically evaluating human spoken language skills is motivated through real life scenarios ranging from call centers to kindergarten classes. This is followed by a definition of the problem. Next, some important works in the domain are presented. Definitions of various relevant terms from speech and language processing subjects are intertwined in the paper to aid the uninitiated reader. This paper concludes by discussing the research challenges in the area.
Expression of c‐sis and other cellular proto‐oncogenes in human sarcoma cell lines and biopsies (1989)

Six biopsies (4 of human fibrosarcomas, 1 of a B-cell lymphoma and 1 of a normal lymph node from a melanoma patient) and 6 cell lines (derived from 5 different human osteosarcomas and from 1 rhabdomyosarcoma), together with control cells, were examined for the expression of c-sis, c-fos and c-myc. The expression of c-sis/PDGF-B-related proteins was also examined in cultured cells (not in biopsies). In situ hybridization studies further showed that the occurrence and level of expression of c-sis mRNA and c-sis/PDGF-B-related proteins were significant in the tumor cells. Expression of c-fos and c-myc mRNA did not correlate with c-sis expression. Southern blot analysis of c-sis, c-fos and c-myc of 20 DNAs of cell lines derived from human sarcoma or biopsies showed an identical pattern for BamH1 and EcoR1 restriction fragments of c-sis (except for 1 fibrosarcoma biopsy), implicating no gene rearrangement as a cause of enhanced proto-oncogene expression. The nucleotide sequence of c-sis is highly homologous to that of the viral v-sis oncogene which is capable of transforming infected cells. We conclude that enhanced expression of c-sis in the sarcomas we have examined is involved in the initiation and/or maintenance of the cell transformed state.
Cloud-Based Information Integration &amp;amp; Informatics Framework for Healthcare Applications (2014)

An information integration and informatics framework for healthcare applications leverages the parallel computing capability of a cloud-based, large-scale distributed batch-processing infrastructure built with commodity hardware. The result is new flexibility for developers of advanced healthcare applications.
Thermally degradable thermosetting materials (2010)

Thermosetting materials have been widely used in a variety of applications but they generally display poor tractability after curing, which limits their use in applications where degradable or re-workable polymers are advantageous. Moreover, recyclability and biodegradability of thermosetting polymer also limit their use in applications where recycling and biodegradation are important. A variety of thermally degradable linkages within thermosetting materials have been studied both in academia and industry to develop re-workable adhesives. This review reports the recent development in thermosetting materials containing thermally breakable linkages that exhibit re-workability as well as potential for recyclability and biodegradability.
Final Report: Mechanistic Studies of Transitional Metal Catalyzed Alternating Copolymerization of Carbon Monoxide with Olefins, July 1, 1994 - May 31, 1998 (1998)

No abstract prepared.
A hybrid display frame buffer architecture for energy efficient display subsystems (2013)

Our principal motivation is to reduce the energy consumption of display subsystems in mobile devices by introducing a hybrid frame buffer architecture into the platform. We observed that display contents on a screen are quite static for certain mobile workloads, such as web browsing. As a result, data reading from the display frame is much more frequent than the writing of new data onto the frame buffer, a state we refer to as read dominance. Based on this observation, we propose a hybrid frame buffer architecture that exploits the display contents' read-dominant property to improve the energy efficiency of display subsystems. Specifically, we employ two memory types: DRAM and Phase-Change Memory (PCM), in the display frame buffer to exploit their different read/write energy characteristics. We also present an analysis of the energy efficiency of the hybrid frame buffer based on our display content and energy consumption models. Our evaluation results show that the proposed hybrid frame buffer reduces frame buffer energy consumption by up to 43%, compared to the conventional DRAM-only frame buffer.
Bragg Grating-Based Switching in Highly-Nonlinear Bismuth-Oxide Fiber (2010)

We report the first demonstration of Bragg grating-based all-optical switching in a highly nonlinear Bi2O3 fiber. At powers as low as 55 W the transmission changes from 90% to 20%, a 6.5 dB extinction ratio.
A new polymorphic probe on chromosome 3p: λLIB08–60‴ (D3S729) (1991)

XLIB43 -55' is a 7.0 kb EcoRI fragment isolated from a Charon 21A human chromosome 3 library (1). Polymorphism: MspI digestion of genomic DNA and hybridization with the probe detects a two allele polymorphism: 7.6 kb (A1) and 4.5 kb (A2). Frequency: Estimated from 120 unrelated Caucasians.
High-speed waveguide switches for optical routers and networks (2004)

This paper presents an optical waveguide switch with a switching time of 1.26-1.39 ns in the C band and demonstrates optical packet switching for an optical packet stream with a 40-Gbps NRZ signal.
Natural products of filamentous fungi: enzymes, genes, and their regulation (2006)

Covering: up to June 2006
Supplementary Figure 6 from Transforming Growth Factor-β Activation Promotes Genetic Context–Dependent Invasion of Immortalized Melanocytes (2023)

Supplementary Figure 6 from Transforming Growth Factor-β Activation Promotes Genetic Context–Dependent Invasion of Immortalized Melanocytes
Interactive Operation Planning and Control with VIRIM (1996)

The VIRIM system, which stands for Virtual Reality In Medicine, aims at realising computer aided surgery (CAS) using methods of virtual reality (VR). In contrast to other approaches the visualisation/segmentation system VIRIM implements both real-time volume ray-casting as visualisation method and real-time grey-value segmentation. VIRIM is currently the first realtime volume ray-casting system. In contrast to most other systems no special data preparation like surface extraction is necessary. Different volume ray-casting algorithms can be implemented in VIRIM and arbitrary opacity levels are possible for the structures that are visualised.
Confinement of C70 in an extended saddle shaped nickel(II) macrocycle (1999)

Saddle shaped {2,3,6,8,11,12,15,17-octamethyldibenzo-[b,i]1,4,8,11-tetraaza(1,4)annulene}nickel(II), Ni(OMTAA),acts as a heterotropic divergent receptor molecule with C70 forming a 1:1 complex in the solid state, where the extended supramolecular array consists of zigzag alternating C70–Ni(OMTAA) chains and corrugated sheets of close contact C70 molecules.
Correlation between the degree of hemolysis and acoustic impedance, speed of sound, and attenuation in flowing whole blood (2006)

The effect of increasing levels of mechanical hemolysis on the propagation of 15-MHz ultrasound in flowing whole blood at 37&amp;lt;th&amp;gt;°C was investigated. An experimental setup was developed, which enabled the continuous measurement of attenuation, speed of sound, and acoustic impedance in porcine whole blood under conditions of laminar flow and mean shear rates well above the threshold for red cell aggregation. Starting with an initial hematocrit of 35%, an increasing volume fraction of the blood in the flow loop was hemolyzed by exposure to very high shear stresses. The attenuation coefficient at 15 MHz was found to vary between 1 dB/cm for 0% hemolysis (no red cell damage) to 5 dB/cm for 75% hemolysis, remaining approximately constant for higher hemolysis levels. Speed of sound decreases from 1561 m/s for healthy blood to 1545 m/s for 80% hemolysis. Finally, acoustic impedance was also found to vary from a minimum of 1575 Kg/m2 to 1589 Kg/m2 between 15% and 90% hemolysis. These results show great promise towards solving the inverse problem, namely developing a technique capable of deducing the degree of hemolysis noninvasively and in real time based on measured changes in ultrasound parameters.
Molecular theory for mixed micelles (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular theory for mixed micellesR. NagarajanCite this: Langmuir 1985, 1, 3, 331–341Publication Date (Print):May 1, 1985Publication History Published online1 May 2002Published inissue 1 May 1985https://pubs.acs.org/doi/10.1021/la00063a012https://doi.org/10.1021/la00063a012research-articleACS PublicationsRequest reuse permissionsArticle Views1373Altmetric-Citations183LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Design and Assessment of Anti-Biofilm Peptides: Steps Toward Clinical Application (2018)

Highly antibiotic resistant, microbial communities, referred to as biofilms, cause various life-threatening infections in humans. At least two-thirds of all clinical infections are biofilm associated, and antibiotic therapy regularly fails to cure patients. Anti-biofilm peptides represent a promising approach to treat these infections by targeting biofilm-specific characteristics such as highly conserved regulatory mechanisms. They are being considered for clinical application and we discuss here key factors in discovery, design, and application, particularly the implementation of host-mimicking conditions, that are required to enable the successful advancement of potent anti-biofilm peptides from the bench to the clinic.
Antimicrobial Effects of Inula viscosa Extract on the In Situ Initial Oral Biofilm (2021)

Given the undesirable side effects of commercially used mouth rinses that include chemically synthesized antimicrobial compounds such as chlorhexidine, it is essential to discover novel antimicrobial substances based on plant extracts. The aim of this study was to examine the antimicrobial effect of <i>Inula viscosa</i> extract on the initial microbial adhesion in the oral cavity. Individual test splints were manufactured for the participants, on which disinfected bovine enamel samples were attached. After the initial microbial adhesion, the biofilm-covered oral samples were removed and treated with different concentrations (10, 20, and 30 mg/mL) of an <i>I. viscosa</i> extract for 10 min. Positive and negative controls were also sampled. Regarding the microbiological parameters, the colony-forming units (CFU) and vitality testing (live/dead staining) were examined in combination with fluorescence microscopy. An <i>I. viscosa</i> extract with a concentration of 30 mg/mL killed the bacteria of the initial adhesion at a rate of 99.99% (log<sub>10</sub> CFU value of 1.837 ± 1.54). Compared to the negative control, no killing effects were determined after treatment with <i>I. viscosa</i> extract at concentrations of 10 mg/mL (log<sub>10</sub> CFU value 3.776 ± 0.831; median 3.776) and 20 mg/mL (log<sub>10</sub> CFU value 3.725 ± 0.300; median 3.711). The live/dead staining revealed a significant reduction (<i>p</i> < 0.0001) of vital adherent bacteria after treatment with 10 mg/mL of <i>I. viscosa</i> extract. After treatment with an <i>I. viscosa</i> extract with a concentration of 30 mg/mL, no vital bacteria could be detected. For the first time, significant antimicrobial effects on the initial microbial adhesion in in situ oral biofilms were reported for an <i>I. viscosa</i> extract.
Antibody Profiles According to Mild or Severe SARS-CoV-2 Infection, Atlanta, Georgia, USA, 2020 (2020)

Among patients with coronavirus disease (COVID-19), IgM levels increased early after symptom onset for those with mild and severe disease, but IgG levels increased early only in those with severe disease. A similar pattern was observed in a separate serosurveillance cohort. Mild COVID-19 should be investigated separately from severe COVID-19.
Energy propagation with phase velocity in a waveguide (1991)

Abstract Transit‐time measurements of the leading edge of pulse‐modulated microwaves propagating in a waveguide have been performed in time domain. These measurements show that a part of the energy associated with the leading edge of the pulse propagates with a phase velocity exceeding the intrinsic velocity in free space. Calibration techniques and repeated measurements confirm this phenomenon.
Tissue Array Substratum Composed of Histological Sections: A New Platform for Orienting Differentiation of Embryonic Stem Cells Towards Hepatic Lineage (2008)

Culture technologies for differentiating embryonic stem cells (ESCs) into hepatic cells generally require some growth factors for several days. Here we present a new technology for efficiently differentiating mouse ESCs into hepatocyte-like cells in a supplement-free basal medium by using a tissue array substratum composed of histological sections. The substratum was prepared from liver tissues in various stages after administration of carbon tetrachloride to mice. The substrata derived from regenerating livers enhanced cell attachment, supported growth as clusters, and induced differentiation into cells expressing albumin, although the substrata from injured livers did not. In particular, the cells cultured on the most-proliferative regenerating liver-derived section substratum reconstructed the hepatic cord-like structures with bile canaliculus-like aspects in which some binucleated cells were involved, secreted albumin, and expressed cytochrome P450IA1 activity within a few days. This culture technology also provides a novel concept for Histomics, categorizing the features of different tissues based on the behavior of a cell line cultured on their array substratum (i.e., tissuome).
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells (2022)

POLQ is a key effector of DSB repair by microhomology-mediated end-joining (MMEJ) and is overexpressed in many cancers. POLQ inhibitors confer synthetic lethality in HR and Shieldin-deficient cancer cells, which has been proposed to reflect a critical dependence on the DSB repair pathway by MMEJ. Whether POLQ also operates independent of MMEJ remains unexplored. Here, we show that POLQ-deficient cells accumulate post-replicative ssDNA gaps upon BRCA1/2 loss or PARP inhibitor treatment. Biochemically, cooperation between POLQ helicase and polymerase activities promotes RPA displacement and ssDNA-gap fill-in, respectively. POLQ is also capable of microhomology-mediated gap skipping (MMGS), which generates deletions during gap repair that resemble the genomic scars prevalent in POLQ overexpressing cancers. Our findings implicate POLQ in mutagenic post-replicative gap sealing, which could drive genome evolution in cancer and whose loss places a critical dependency on HR for gap protection and repair and cellular viability.
Abstract 12035: Text and Data Mining of Longitudinal Electronic Health Records (EHRs) in a Primary Care Population Can Identify Heart Failure (HF) Patients Months to Years Prior to Formal Diagnosis Using the Framingham Criteria (2011)

Introduction: The societal and individual health burden of HF is enormous. While its early recognition offers the possibility of initiating preventive action, earlier detection of HF can be challen...
Role of N‐linked glycosylation in expression of E‐selectin on human endothelial cells (1995)

E-selectin is a cytokine-inducible membrane glycoprotein capable of mediating adhesion of leukocytes to endothelial cells. It is highly glycosylated, containing 11 sites for N-linked glycosylation. N-Glycosylation of E-selectin was analyzed by endoglycosidase treatment. Analysis of immunoprecipitated E-selectin from human umbilical vein endothelial cells (HUVEC) by polyacrylamide gel electrophoresis in the presence of sodium dodecylsulfate showed that E-selectin was completely resistant to endoglycosidase H, but sensitive to peptide N-glycanase F digestion. This suggested that all N-linked oligosaccharide chains were of the complex type. The role of N-linked glycosylation in surface expression and secretion of E-selectin was studied using interleukin-1-stimulated HUVEC, cultured in the presence of the soluble glycosylation inhibitors tunicamycin or castanospermine. Cell surface expression was analyzed by indirect flow cytometry. N-Glycosylation was blocked by tunicamycin, and resulted in a significantly reduced surface expression of E-selectin, whereas castanospermine only marginally reduced E-selectin expression. The deglycosylated forms of E-selectin were also found to be fully capable of mediating adhesion of HT-29 cells in vitro. In conclusion, these studies show that E-selectin is heavily glycosylated with complex type N-linked oligosaccharides and that N-glycosylation is important for expression of E-selectin on human endothelial cells.
On line rates, information rates, and spectral efficiencies in probabilistically shaped QAM systems (2018)

We carefully revisit the definitions of line rates, information rates, and spectral efficiencies in probabilistically shaped optical transmission systems. Generally accepted definitions for uniform quadrature amplitude modulation (QAM) systems are extended to more generally apply to systems with probabilistically shaped QAM, as well as to systems using pilot symbols of different QAM order than the information symbols. Based on the proper definitions, we correct erroneous claims in a recently reported work.
Effect of the Amount of Austenite Precipitated on the Charpy Absorbed Energy for Ductile Fracture of 9% Ni Steel (1986)

An investigation was made on the effect of the amount of austenite precipitated on the Charpy absorbed energy for ductile fracture of high toughness 9% Ni steel. The main results obtained are as follows:(1) As slab reheating temperature and finish-rolling temperature are raised; the Charpy absorbed energy for ductile fracture increases.(2) As slab reheating temperature and finish-rolling temperature are raised, the amount of austenite precipitated decreases.(3) The Charpy absorbed energy for ductile fracture has a good relation with the amount of austenite precipitated.(4) The fraction of area of dimples smaller than one μm increases with an increase in the amount of austenite precipitated.(5) The Ni content measured at the bottom of dimples smaller than one μm by micro Auger analysis is as much as that of austenite.(6) The above results indicate that the austenite precipitated decreases the Charpy absorbed energy for ductile fracture through the formation of dimples smaller than one μm.
Design and optimization of low voltage high performance dual threshold CMOS circuits (1998)

Reduction in leakage power has become an important concern in low voltage, low power and high performance applications. In this paper, we use dual threshold technique to reduce leakage power by assigning high threshold voltage to some transistors in non-critical paths, and using low-threshold transistors in critical paths. In order to achieve the best leakage power saving under target performance constraints, an algorithm is presented for selecting and assigning an optimal high threshold voltage. A general standby leakage current model which has been verified by IISPICE is used to estimate standby leakage power. Results show that dual threshold technique is good for power reduction during both standby and active modes. The standby leakage power savings for some ISCAS benchmarks can be more than 50%.