gebhart/patrepeval huggingface dataset:
Intelligent Surface Optimization in Terahertz under Two Manifestations\n of Molecular Re-radiation (2021)

The operation of Terahertz (THz) communication can be significantly impacted\nby the interaction between the transmitted wave and the molecules in the\natmosphere. In particular, it has been observed experimentally that the signal\nundergoes not only molecular absorption, but also molecular re-radiation. Two\nextreme modeling assumptions are prevalent in the literature, where the\nre-radiated energy is modeled in the first as additive Gaussian noise and in\nthe second as a scattered component strongly correlated to the actual signal.\nSince the exact characterization is still an open problem, we provide in this\npaper the first comparative study of the performance of a reconfigurable\nintelligent surface (RIS) assisted THz system under these two extreme models of\nre-radiation. In particular, we employ an RIS to overcome the large pathloss by\ncreating a virtual line-of-sight (LOS) path. We then develop an optimization\nframework for this setup and utilize the block-coordinate descent (BCD) method\nto iteratively optimize both RIS configuration vector and receive beamforming\nweight resulting in significant throughput gains for the user of interest\ncompared to random RIS configurations. As expected, our results reveal that\nbetter throughput is achieved under the scattering assumption for the molecular\nre-radiation than the noise assumption.\n
First Human Case of Fungal Keratitis Caused by a Putatively Novel Species of (2015)

1 Department of Ophthalmology, the Johns Hopkins University School of Medicine, 7 Baltimore, Maryland; 2 University of Alberta Microfungus Collection and Herbarium, 8 Edmonton, Alberta, Canada; 3 Department of Pathology, the Johns Hopkins University 9 School of Medicine; 4 Microbiology Laboratory, the Johns Hopkins Hospital, Baltimore, 10 Maryland, USA; 5 Fungus Testing Laboratory, Department of Pathology, University of 11 Texas Health Science Center, San Antonio, Texas, USA. 12
Endogenous UDP-Glc acts through the purinergic receptor P2RY14 to exacerbate eosinophilia and airway hyperresponsiveness in a protease model of allergic asthma (2019)

Abstract Human asthma represents a wide spectrum of pathologies that likely arise through distinct molecular pathways, and a major therapeutic goal is to target individual therapies to specific forms, or endotypes, of this disease. Here we studied the role of UDP-glucose (UDP-Glc), an alarmin which we found to be released into the airways of allergen-sensitized mice upon their subsequent challenge with allergen. UDP-Glc signals through the purinergic receptor, P2Y14R, and mice lacking this receptor display marked attenuation of both eosinophilia and airway hyperresponsiveness (AHR) in a protease model of allergic asthma. By contrast, these features of asthma were similar in wild type and P2ry14-deficient mice in a TLR-ligand model of asthma, indicating an endotype-specific role for UDP-Glc and P2Y14R. Importantly, administrationof PPTN, a small molecule antagonist of P2Y14R, also led to reduction of airway inflammation and AHR in the protease mediated asthma. Although its mechanism of action remains unclear, P2ry14 was most highly expressed in recruited eosinophils and neutrophils, suggesting UDP-Glc acts directly on these cells. Our current findings suggest that antagonists of P2Y14R might be selectively used to control asthma exacerbations in specific forms of human asthma.
Immunodominant antigen of Actinobacillus actinomycetemcomitans Y4 in high-responder patients (1989)

This study was undertaken to look for characteristics of the immunodominant antigen(s) of Actinobacillus actinomycetemcomitans Y4 that might help explain the high antibody titers in periodontitis patients. Radioimmunoassays (RIA) were performed on sera from 481 patients; sera from the 32 patients with the highest anti-Y4 titers (above 128,000 RIA U/ml) were further analyzed. Y4 antigen was boiled for 45 min or treated with papain, and antibody responses were analyzed by RIA and Western blotting (immunoblotting). In addition, carbohydrate was purified from Y4 and examined by Western blotting. The results indicated that the immunodominant antigen of Y4 in high responders was stable after papain treatment or boiling for 45 min. Papain or boiling eliminated protein bands but a large diffuse band persisted on Western blots. With increasing dilutions of sera, bands on Western blots corresponding to protein antigens disappeared, while the large diffuse band resembling that of carbohydrate persisted. Partially purified Y4 carbohydrate contained the large diffuse band. Double-immunodiffusion analysis indicated that rabbit serotype b-specific antiserum and patient sera recognized the same antigen. When the carbohydrate extract was passed over a lipid A-binding column to remove lipopolysaccharide, the smear corresponding to the immunodominant antigen was still present on Western blots. The immunodominant antigen of Y4 in high-responder individuals appears to be a carbohydrate and is possibly the capsular polysaccharide.
Ionizing Radiation-induced Apoptosis in Ataxia-Telangiectasia Fibroblasts (2001)

Ionizing radiation (IR) has been shown to induce apoptosis to a greater extent in a fibroblast cell line AT5BIVA derived from an individual with ataxia-telangiectasia (AT) than in control fibroblasts. However, the signaling pathway that underlies IR-induced apoptosis in AT cells has remained unknown. The mechanism of apoptosis in response to gamma-irradiation has now been examined in three AT fibroblast lines (AT3BIVA, AT4BIVA, and AT5BIVA) derived from different individuals with AT. The apoptotic indexes of these cell lines at 72 h after irradiation were 12, 31, and 35%, respectively, compared with a value of 2.3% for control fibroblasts. Immunoblot analysis and fluorometric assays revealed that the extents of IR-induced activation of caspase-3 and caspase-9 were markedly greater in AT4BIVA and AT5BIVA cells than in AT3BIVA and control cells. Furthermore, the basal abundance of the apoptotic inhibitor, a cellular inhibitor of apoptosis proteins (c-IAP-1), was markedly reduced in AT4BIVA and AT5BIVA cells compared with that in AT3BIVA and control cells. The overexpression of either caspase-9 mutant forms or recombinant c-IAP-1 in AT5BIVA cells inhibited the IR-induced activation of caspases-3 and 9 and reduced the apoptotic index of the irradiated cells. These results indicate that the extent of IR-induced apoptosis in different AT cell lines is inversely related to the abundance of c-IAP-1 and directly related to the extent of activation of caspases-3 and 9.
ChemInform Abstract: 1‐(Azidomethyl)benzotriazole and ‐5‐phenyl‐1,2,3,4‐tetrazole as 1,3‐ Dipolar Cycloaddition Components. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
JackHammer: Efficient Rowhammer on Heterogeneous FPGA-CPU Platforms (2020)

After years of development, FPGAs are finally making an appearance on multi-tenant cloud servers. Heterogeneous FPGA-CPU microarchitectures require reassessment of common assumptions about isolation and security boundaries, as they introduce new attack vectors and vulnerabilities. In this work, we analyze the memory and cache subsystem and study Rowhammer and cache attacks enabled by two proposed heterogeneous FPGA-CPU platforms from Intel: the Arria 10 GX with an integrated FPGA-CPU platform, and the Arria 10 GX PAC expansion card which connects the FPGA to the CPU via the PCIe interface. We demonstrate JackHammer, a novel, efficient, and stealthy Rowhammer from the FPGA to the host’s main memory. Our results indicate that a malicious FPGA can perform twice as fast as a typical Rowhammer from the CPU on the same system and causes around four times as many bit flips as the CPU attack. We demonstrate the efficacy of JackHammer from the FPGA through a realistic fault attack on the WolfSSL RSA signing implementation that reliably causes a fault after an average of fifty-eight RSA signatures, 25% faster than a CPU Rowhammer. In some scenarios our JackHammer attack produces faulty signatures more than three times more often and almost three times faster than a conventional CPU Rowhammer. Finally, we systematically analyze new cache attacks in these environments following demonstration of a cache covert channel across FPGA and CPU.
A Gm -Boosting Technique for Millimeter-Wave Low-Noise Amplifiers in 28-nm Triple-Well Bulk CMOS Using Floating Resistor in Body Biasing (2022)

This paper presents a simple yet effective <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$G_{m}$ </tex-math></inline-formula> -boosting technique for improving gain and noise performance of millimeter-wave (mm-wave) low-noise amplifiers (LNAs) comprising triple-well transistors typically found in the modern bulk CMOS processes. The proposed technique uses a resistor that connects the p-well and deep n-well terminals of the triple-well transistor, leaving the terminals floating instead of conventionally connecting them to the ground and supply voltage. This arrangement exploits a leakage current through a diode formed between the drain/source and p-well of each transistor, thus autonomously setting its bulk potential for increased transconductance, while ensuring its robustness to the process variation. The improved isolation between the p-well and the substrate further improves the gain and noise performance. We provide a theoretical analysis of this floating resistor-based body biasing method and support it with simulation results. For experimental validation, a two-stage cascode LNA was designed and fabricated in 28-nm bulk CMOS. The measurement results show that 3.3–4dB noise figure (NF) and 19.1–16.1dB gain are achieved at 24.7–29.5GHz. To ensure a fair comparison, another identical LNA with the normally expected triple-well biasing was also fabricated. The proposed method reveals a 0.6dB improvement in minimum NF and an additional ~3.5dB gain without any significant linearity degradation.
Implementations of on sensor image compression and comparisons between pixel and column parallel architectures (2002)

In order to enhance performance of an image sensor, we have been investigating a novel integration of compression and sensing. By this integration, the image signal that has to be readout from the sensor is significantly reduced. Thus, the integration can consequently leads to high pixel rate sensing. The compression scheme we make use of is conditional replenishment that detects and encodes moving areas. We have developed prototypes based on two different architectures, that are pixel parallel and column parallel architectures. We present the two prototypes and their comparisons, and show the results obtained by them.
SOT-MRAM Based Analog in-Memory Computing for DNN Inference (2020)

Deep neural network (DNN) inference requires a massive amount of matrix-vector multiplications which can be computed efficiently on memory arrays in an analog fashion. This approach requires highly resistive memory devices with low resistance variability to implement DNN weight memories. We propose an optimized Spin-Orbit Torque MRAM (SOT-MRAM) as weight memory in Analog in-Memory Computing (AiMC) systems for DNN inference. In SOT-MRAM the write and read path are decoupled. This allows changing the MTJ resistance to the high levels required for AiMC by tuning the tunnel barrier thickness without affecting the writing. The target resistance level and variation are derived from an algorithm driven design-technology-co-optimization (DTCO) study. Resistance levels are obtained from IR-drop simulations of a convolutional neural network (CNN). Variation limits are obtained by testing two noise-resilient CNNs with conductance variability. Finally, we demonstrate experimentally that the requirements for analog DNN inference are met by SOT-MRAM stack optimization.
Cathodoluminescence as a Method of Microstructure Characterization of Biphasic Ceramics Composed of Hydroxyapatite and β-Tricalcium Phosphate (2005)

This paper describes the investigation into the use of cathodoluminescence for distinguishing HA and β-TCP phases within the biphasic calcium phosphate ceramic microstructure. Polished samples were scanned using SEM-CL at an accelerating voltage in the range of 10-15 keV with a beam current of 5-10 nA. The grayscale images produced reveal distinctive patterns for each composition. EDS and EPMA suggest chemical differences among the contrasting regions. Image analysis of voxel values indicate that areas of bright contrast correspond to β-TCP grains with phase amounts confirmed by XRD.
Association of c-Raf expression with survival and its targeting with antisense oligonucleotides in ovarian cancer (2001)

c-Raf is an essential component of the extracellular related kinase (ERK) signal transduction pathway. Immunohistochemical staining indicated that c-Raf was present in 49/53 ovarian adenocarcinomas investigated and high c-Raf expression correlated significantly with poor survival (P = 0.002). c-Raf protein was detected in 15 ovarian cancer cell lines. Antisense oligodeoxynucleotides (ODNs) (ISIS 5132 and ISIS 13650) reduced c-Raf protein levels and inhibited cell proliferation in vitro. Selectivity was demonstrated by the lack of effect of ISIS 5132 on A-Raf or ERK, while a random ODN produced only minor effects on growth and did not influence c-Raf expression. ISIS 5132 produced enhanced apoptosis and cells accumulated in S and G(2)/M phases of the cell cycle. In vivo, ISIS 5132 inhibited growth of the s.c. SKOV-3 xenograft while a mismatch ODN had no effect. These data indicate that high levels of c-Raf expression may be important in ovarian cancer and use of antisense ODNs targeted to c-Raf could provide a strategy for the treatment of this disease.
Quantification of Large Deformation with Punching in Dual Phase Steel and Change of its’ Microstructure – Part I: Proposal of the Quantification Technique of the Punching Damage of the Dual Phase Steel (2016)

Dual Phase (DP) steel is used in automotive body parts for weight saving and crashworthiness, however there is an issue of DP steel in low stretch flange ability evaluated by hole expanding tests. In order to improve stretch flange ability of DP steel, it is important to estimate the damage of punching quantitatively and to clarify the change of microstructure before and after punching because the hole expansion ratio is decided in the ductility remained after pre-strain equivalent to punching. Therefore we tried to measure the damage of punching by unique techniques of Electron Backscatter Diffraction (EBSD), nano-indentation and micro-tensile testing and to observe fracture surface by Scanning Transmission Electron Microscope (STEM). Average EBSD-Kernel Average Misorientation (KAM) value and pre-strain damage have strong correlation, thus average KAM value can become the index of the damage. The nanohardness and tensile strength using micrometer-sized specimens increased with increasing average KAM value in the ferritic phase as approaching the punching edge. A shear type fracture occurred without necking in the specimen cut out in the area of the edge. The ultrafine-grained ferritic microstructure was observed in the sample cut out in the same area with STEM. It seems that the ductility loss of the punched DP steel was probably attributed to localized strain into the ultrafine-grained ferritic microstructure.
Grid-based Quasi-Monte Carlo Applications (2005)

In this paper, we extend the techniques used in Grid-based Monte Carlo applications to Grid-based quasi-Monte Carlo applications. These techniques include an N-out-of-M strategy for efficiently scheduling subtasks on the Grid, lightweight checkpointing for Grid subtask status recovery, a partial result validation scheme to verify the correctness of each individual partial result, and an intermediate result checking scheme to enforce the faithful execution of each subtask. Our analysis shows that the extremely high uniformity seen in quasirandom sequences prevents us from applying many of our Grid-based Monte Carlo techniques to Grid- based quasi-Monte Carlo applications. However, the use of scrambled quasirandom sequence becomes a key to tackling this problem, and makes many of the techniques we used in Grid- based Monte Carlo applications effective in Grid-based quasi-Monte Carlo applications. All the techniques we will describe here contribute to performance improvement and trustworthiness enhancement for large-scale quasi-Monte Carlo applications on the Grid, which eventually lead to a high-performance Grid-computing infrastructure that is capable of providing trustworthy quasi-Monte Carlo computation services.
Discovery of a Ce3+-activated red nitride phosphor for high-brightness solid-state lighting (2020)

A Ce<sup>3+</sup>-doped red phosphor was screened and developed for high-power solid state lighting.
Predicting initial treatment failure of fiberglass casts in pediatric distal radius fractures: Utility of the second metacarpal-radius angle (2009)

We agree with prior studies suggesting the equal efficacy of below-elbow versus above-elbow casts in distal radius and ulna fracture treatment using either plaster or fiberglass, but wish to emphasize the importance of not only the cast index, but also the ulnar deviation mold (for most dorsally displaced fractures), as measured by the second metacarpal-radius angle.
Impact of N -Chlorotaurine on Viability and Production of Secreted Aspartyl Proteinases of Candida spp (2002)

N-Chlorotaurine, an endogenous long-lived oxidant, demonstrated fungicidal activity against Candida spp. and a postantifungal effect. Secreted aspartyl proteinases, important fungal virulence factors, proved to be a first target of impact. These results provide support for the topical application of N-chlorotaurine as an antimicrobial agent in yeast infections.
IP Session on Chiplet: Design, Assembly, and Test (2023)

This IP session will consist of three presentations. A summary of each presentation is given below.
An X-Ray Topographic Analysis of the Crystal Quality of Globally Available SiC Wafers (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Comparison of Broad vs Narrow Focal Width Lithotripter Fields (2017)

A lithotripter field with broad beam size yields superior stone comminution when compared with narrow beam size under comparable effective acoustic pulse energy both in vivo and in vitro. These findings may facilitate future improvements in lithotripter design to maximize comminution efficiency while minimizing tissue injury.
Adenovirus‐mediated suicide‐gene therapy in an orthotopic murine bladder tumor model (2002)

Suicide-gene therapy using Ad-RSV-TK/GCV provides an effective therapy in an experimental murine orthotopic bladder cancer by significantly inhibiting tumor growth and improving long-term host survival.
MOSFET modeling gets physical (2001)

The importance of obtaining a compact analytical MOSFET model with physical model parameters is increasing with the complexity of IC design and by pushing the technology to its limit. Here we have reviewed the known modeling approaches and demonstrated that the surface-potential description based on the drift-diffusion approximation is practical and able to satisfy the foreseeable future requirements. It consequently opens a viable way to secure the robustness and reliability of circuit simulation results for future sub-100 nm MOSFET generations.
Dielectric Properties of Lead Alkaline-Earth Zirconate at Microwave Frequencies (1991)

Dielectric properties of alkaline-earth-substituted PbZrO 3 ceramics up to microwave frequencies were investigated. Although there were no preferable characteristics in the Ba- or Sr-substituted system, the ceramics in a (PbCa)ZrO 3 system showed not only high dielectric constants in the range of 100 to 118, but also high Q values of 1000 to 1150 and small temperature coefficients of resonant frequency of 0 to 30 ppm/ °C. The crystal structure of the Ca-substituted ceramics was also investigated by X-ray powder diffraction. The structure changed from PbZrO 3 -type orthorhombic to CaZrO 3 -type orthorhombic through cubic and rhombohedral with increasing Ca substitution. Coaxial dielectric resonators made of the selected above material had Q values in the range of 430 to 450 at the 900 MHz band.
Serum interferon‐inducible protein 10 levels predict hepatitis B s antigen seroclearance in patients with chronic hepatitis B (2015)

Lower serum IP-10 level at Year 0 was the only factor associated with HBsAg seroclearance.
Blocked Pathways: FTIs Shut Down Oncogene Signals (2003)

Ras proteins play fundamental roles in cell signal transduction pathways that regulate cell growth, differentiation, proliferation, and survival. ras mutations are among the most frequently encountered genetic abnormalities in human cancers and play a key role in tumorigenesis. The enzymatic attachment of a 15- or 20-carbon moiety to the Ras protein through farnesylation or geranylgeranylation, respectively, is a required step in the proper localization and activation of Ras. Inhibition of the catalytic enzymes, farnesyl transferase and geranylgeranyl transferase, is a novel, mechanism-based, targeted approach to cancer therapy development. Geranylgeranyl transferase inhibitors suppress tumor growth by accumulating cells in the G(1)/S cell cycle phase. One mechanism by which farnesyl transferase inhibitors suppress tumor growth is by inhibiting bipolar spindle formation, thereby blocking progression from prophase to metaphase. Although the exact molecular target responsible for the antitumor activity of farnesyl transferase inhibitors is unclear, at least in some tumor cells, inhibition of phosphoinositide-3-OH kinase/Akt-mediated cell survival pathways may play a critical role. Identifying the farnesylated proteins that are targeted by farnesyl transferase inhibitors and the tumor molecular signatures that dictate which set of patients will respond to farnesyl transferase inhibitors are critical end points for future mechanistic studies.
The Critical Role of Carbon in the Chemical Delithiation Kinetics of LiFePO4 (2020)

The chemical delithiation of LiFePO 4 has been carefully studied using two different types of LiFePO 4 : (1) carbon coated LiFePO 4 and (2) non-carbon coated LiFePO 4 . We have observed that only carbon coated LiFePO 4 can be successfully delithiated at room temperature using Na 2 S 2 O 8 as oxidizing agent. In order to unravel the role of carbon in the chemical delithiation process of non-carbon coated LiFePO 4 we have performed a systematic study using different carbon sources as well as different amount of extraneous carbon in the solution. The results obtained demonstrate that the addition of carbon is fundamental for the effective removal of lithium at room temperature, and only a very small amount of carbon of any nature is enough to achieve the successful chemical delithiation of non-carbon coated LiFePO 4 .