gebhart/patrepeval huggingface dataset:
Vaccination of colorectal cancer patients with carcinoembryonic antigen peptide-loaded dendritic cells (2005)

2544 Dendritic cells (DC) are the most potent antigen presenting cells of the immune system, capable of inducing an effective anti-tumor immune response. They can be cultured in large quantities from peripheral blood monocytes from cancer patients, loaded with tumor antigen ex vivo and subsequently reinjected into the patients. Currently DC are employed by us and others in clinical vaccination protocols and objective clinical and immunological responses have been observed. Recent investigations indicate that carcinoembryonic antigen (CEA) is an effective target for DC-based immunotherapy. However, very little data exist concerning the induction of an in vivo immune response, in colorectal cancer patients. We have initiated a clinical study with keyhole limpet hemocyanin (KLH) and CEA-peptide loaded DC in HLA-A2.1 positive patients with resectable liver metastases of recurrent colorectal cancer. Patients are vaccinated 3 times intravenously and intradermally with autologous CEA-loaded mature DC prior to surgical resection of the metastases. Immuno-monitoring consists of T cell responses in peripheral blood, delayed type hypersensitivity (DTH) reactions, and in resected tumor and lymph node material. To date, 7 patients have completed vaccination. Treatment was well tolerated with minor side effects. Vaccination resulted in an antibody response and a proliferative T cell response against KLH in all tested patients. Furthermore, CEA-peptide specific T cells were observed in T cell cultures from positive DTH reaction sites in 5 pts. These T cells were not detected in biopsy specimens of the first vaccination site, indicating a de novo induction. CEA-tetramer positive T cells were also detected in blood (1 pt) and abdominal lymph nodes (1 pt) obtained after vaccination. Together, these results demonstrate that CEA-pulsed dendritic cells are capable of inducing specific immune reactions in colorectal cancer patients. Our previous results have shown that specific T cell responses in DTH infiltrating T lymphocytes in stage IV melanoma patients were correlated with survival (de Vries et al. submitted for publication). Therefore these observations warrant further confirmation in our ongoing study. No significant financial relationships to disclose.
Attacks on Search RLWE. (2015)

Abstract. We describe a new attack on the Search Ring Learning-With-Errors (RLWE) problem based on the chi-square statistical test, and give examples of RLWE instances in Galois number fields which are vulnerable to our attack. We prove a search-to-decision reduction for Galois fields which applies for any unramified prime modulus q, regardless of the residue degree f of q, and we use this in our attacks. The time complexity of our attack is O(q2f), where f is the residue degree of q in K. We also show an attack on the RLWE problem in general cyclotomic rings (non 2-power cyclotomic rings) which works when the modulus is a ramified prime. We demonstrate the attacks in practice by finding many vulnerable instances and successfully attacking them. We include the code for all attacks. 1
Catecholamine Mediates Psychological Stress-Induced Colitis Through a2-Adrenoreceptor (2015)

Psychological stress has long been reported to be linked with the disease activity of patients with inflammatory bowel disease (IBD). However, the mechanisms of psychological stress involved in pathogenesis of IBD are still to be elucidated. We have previously shown that catecholamine participates in progression of acute colitis through a2-adrenoreceptors. The study aimed to explore the pivotal role of catecholamine in psychological stress-induced colitis. The expression of dopamine β-hydroxylase (DBH), the rate-limiting enzyme in regulation of catecholamine synthesis, was induced in colon tissues of mice with restraint stress, indicating the association of catecholamine synthesis with psychological stress. Notably, pretreatment with RX821002, an a2-adrenoceptor antagonist, attenuated inflammatory responses of psychological stress-induced colitis. Intriguingly, DBH levels were elevated in colon tissues of patients with active IBD. The study suggests that a2-adrenoreceptors/catecholamine play pivotal role in psychological stress-induced colitis and might contribute to the development of human IBD.
Modification of Xanthan Gum for a High-Temperature and High-Salinity Reservoir (2021)

Tertiary oil recovery, commonly known as enhanced oil recovery (EOR), is performed when secondary recovery is no longer economically viable. Polymer flooding is one of the EOR methods that improves the viscosity of injected water and boosts oil recovery. Xanthan gum is a relatively cheap biopolymer and is suitable for oil recovery at limited temperatures and salinities. This work aims to modify xanthan gum to improve its viscosity for high-temperature and high-salinity reservoirs. The xanthan gum was reacted with acrylic acid in the presence of a catalyst in order to form xanthan acrylate. The chemical structure of the xanthan acrylate was verified by FT-IR and NMR analysis. The discovery hybrid rheometer (DHR) confirmed that the viscosity of the modified xanthan gum was improved at elevated temperatures, which was reflected in the core flood experiment. Two core flooding experiments were conducted using six-inch sandstone core plugs and Arabian light crude oil. The first formulation-the xanthan gum with 3% NaCl solution-recovered 14% of the residual oil from the core. In contrast, the modified xanthan gum with 3% NaCl solution recovered about 19% of the residual oil, which was 5% higher than the original xanthan gum. The xanthan gum acrylate is therefore more effective at boosting tertiary oil recovery in the sandstone core.
Low Power Clock Generator Design With CMOS Signaling (2021)

The requirement for longer battery life in laptop computers, cell phones, and other IoT devices while increasing performance with higher frequency and more cores, drives the needs for more clock generators with increased performance (frequency and jitter) and lower power budgets. The traditional current mode low swing clock generators were used widely in industry about 10 years ago. Although it had the advantage of higher supply noise rejection due to the differential nature of the architectures, however, it had the disadvantages of high-power consumption, large layout area, and not friendly to process scaling. Contrary to current mode low swing design, clock generator architectures with CMOS large swing signaling, which have advantages of low power consumption, small area, and based on circuits friendly to process scaling, have been widely adopted for clocking generation in the industry since 2009. In this paper, phase locked loops, delay locked loops, phase interpolators, high resolution digital to time converter and clock distribution techniques with CMOS large swing signaling will be discussed and reviewed.
Fully organic ITO replacement through acid doping of double-walled carbon nanotube thin film assemblies (2011)

Transparent electrodes made from metal oxides, of which indium tin oxide (ITO) is most common, suffer from poor mechanical flexibility and electrochemical stability. Highly transparent and electrically conductive thin films based on double-walled carbon nanotubes (DWNTs) were assembled layer-by-layer (LbL) as a potential replacement for ITO. The alternate deposition of positively charged poly(diallyldimethyl ammonium chloride) [PDDA] and DWNTs, stabilized with negatively charged deoxycholate (DOC), exhibits linear film growth. A five bilayer (BL) assembly exhibits a sheet resistance of 309 Ω sq−1, and visible light transmittance of 84%. In an effort to further reduce sheet resistance, these thin films were exposed to HNO3 vapor. Sheet resistance of the 5 BL film was reduced to 104 Ω sq−1 (4200 S cm−1 conductivity, 22.9 nm thickness), with no change in transparency. Single-walled carbon nanotube assemblies show an even greater change when exposed to HNO3 vapor, with a 5 BL assembly (%T > 85) decreasing from 1236 to 237 Ω sq−1. The DWNT-based assemblies maintained their low sheet resistance after repeated bending and also showed excellent electrochemical stability relative to ITO. This work demonstrates the excellent optoelectronic performance, mechanical flexibility, and electrochemical stability of nanotube-based assemblies, which are potentially useful as transparent electrodes for a variety of flexible electronics.
Dual-Band Electrochromism: Plasmonic and Polaronic Mechanisms (2022)

Electrochromic windows that dynamically absorb incident solar irradiation are envisioned as smart technology devices that can reduce power consumption in buildings and accelerate progress toward sustainable development. While regulating the visible light in interior spaces to suite the comfort of occupants, electrochromic windows can also offer thermal control by controlling the flux of solar energy, including infrared radiation. The ability to selectively modulate visible and infrared solar transmittance is denoted as dual-band electrochromism. Dual-band control can be achieved by employing materials that absorb light in different spectral regions when electrochemically charged, with light absorption due to either a polaronic or a plasmonic mechanism, depending on the charging conditions. In this Perspective, we discuss how adopting a plasmonic or a polaronic approach can affect the performance of an electrochromic device in terms of different quantitative figures-of-merit and the challenges and opportunities for designing better dual-band electrochromic devices in the future.
Improved Solid Lipid Nano-formulations for Pulmonary Delivery of Paclitaxel for Lung Cancer Therapy (2021)

Cancer is the second cause of death worldwide after cardiovascular disease and was responsible for an estimated 9.6 million deaths in 2018. Lung cancer remains one of the most deadly cancers and the second most frequent cancer among males and females. In recent times, there has been an increased interest in the formulation of drugs explored for pulmonary delivery due to a number of significant factors. One is the potential of the lung to serve as a portal for the passage of drugs, including peptides and proteins, into the body. On-site administration of anti-cancer chemotherapeutics by inhalation can minimize the adverse effects of systemic administration, with optimum drug accumulation at the active site. Solid lipid nanoparticles (SLNs) are a suitable candidate for this purpose due to their enhanced physical stability, which can withstand increased drug loading and improve pharmacokinetic properties. Paclitaxel has been shown to exhibit a wide range of applications as an anti-cancer agent for the treatment of a number of tumors, including lung cancer. The biodegradable and biocompatible nature of chitosan has been well explored as a therapeutic polymer with characteristic anti-cancer properties. Pulmonary drug delivery vectors based on chitosan formulations have been reported to decrease systemic toxicity of anti-cancer chemotherapeutics and enhance drug bioavailability in the lungs as well as increasing the anti-cancer effects of the drugs. By modifying the surfaces of particulate systems using targeting ligands, engineered particles have been shown to improve cellular uptake and internalization, which, in turn, increases the propensity of cancer cell apoptosis. Interestingly, folic acid receptors are uniquely overexpressed as molecular signatures on the cellular membrane of various cancer cells, including lung cancer. There is a high binding between folate and folate receptors overexpressed on lung cancer cell surfaces, which could be internalized via receptor-mediated endocytosis. Thus, in this chapter, we detail the excellent applications of folate functionalized chitosan SLNs for pulmonary delivery of paclitaxel in lung cancer therapy.
Advance care planning in patients with incurable cancer: study protocol for a randomised controlled trial (2016)

Pre-results; ACTRN12613001288718.
Patient selection for LIVE therapy - From clinical indications to multimodality imaging individual case planning (2021)

Background LIVE (Less Invasive Ventricular Enhancement) with Revivent TC™ is an innovative therapy for symptomatic ischemic Heart Failure (HF). It is designed to reconstruct a negatively remodeled left ventricle (LV) after an anterior myocardial infarction (MI) by plication of the scar tissue. Its indications are specific and, as with any other structural heart intervention, the success of the procedure starts with appropriate patient selection. We aim to present the indications of the technique, crucial aspects in patient selection and individual case planning approach. Methods and Results After clinical evaluation, transthoracic echocardiography is the first imaging modality to be performed in a potential candidate for the therapy. However, definitive indication and detailed case planning rely on late gadolinium-enhanced cardiac magnetic resonance imaging or multiphasic contrast-enhanced cardiac computed tomography. These imaging modalities also assist with relative or absolute contra-indications for the procedure. Individual assessment is done to tailor the procedure to the specifics of the LV anatomy and location of the myocardial scar. Conclusion LIVE procedure is a unique intervention to treat symptomatic heart failure and ischemic cardiomyopathy after anterior MI. It is a highly customizable intervention that allows a patient-tailored approach, based on multimodality imaging assessment and planification.
Rate Splitting Multiple Access for Semi-Grant-Free Transmissions (2021)

Enabled by hybrid grant-based (GB) and grant-free (GF) transmission techniques, GF users of internet of things (IoT) devices and massive machine-type communications (mMTC) meet opportunities to share wireless resources with GB users. In this paper, we propose a rate splitting multiple access (RSMA) strategy for an emerging semi-grant-free (SGF) transmission system to increase connectivity and reliability. In the proposed RSMA assisted SGF (RSMA-SGF) scheme, the GF users apply the rate splitting principle to realize distributed contentions and utilize transmit power most effectively for robust transmissions, meanwhile keeping themselves transparent to the GB user. Compared to existing non-orthogonal multiple access (NOMA) assisted SGF schemes, the RSMA-SGF scheme significantly decreases outage probability and achieves full multiuser diversity gain without restricting the GB and GF users' target rates to a limited value region. Exact expressions and asymptotic analysis for the outage probability are provided to facilitate the system performance evaluation of the proposed RSMA-SGF scheme. Computer simulation results clarify the superior outage performance of the RSMA-SGF scheme and verify the accuracy of the developed analytical results.
Novel and Simplified Procedure to Test Immunity of Low-Power Voltage Transformers (2022)

International technical committees put considerable efforts into the writing process of standards. They always try to find a tradeoff between the rigorous scientific requirements and the practical needs of manufacturers and final users. In addition, researchers keep investigating to improve the existing standards with new procedures, achievements, and findings. The purpose of this work is to contribute to that direction. It introduces a simplified and low-cost procedure to test low-power voltage transformers (LPVTs). The procedure is designed to assess the immunity of LPVTs when subjected to external electric fields. The need for this procedure comes from the existing immunity test, which is efficient but sometimes difficult to implement. The proposed one, instead, is simpler, cheaper, does not require the application of the rated voltage, and can be replicated at all voltage levels. In the paper, the procedure is described and demonstrated with experimental tests. From the results, it is possible to appreciate the validity of the proposed solution and the different ways it could be developed, implemented, and improved.
Can technology solve the clinical problem of 'dry weight'? (2003)

Patients undergoing regular dialysis therapy for end-stage renal disease retain ﬂuid during the interdialyticperiod, which is removed during dialysis. The aim ofsuch ﬂuid removal is to maintain a dry or target weightin the patient. This weight was deﬁned as the lowestweight that the patient could tolerate without anyintradialytic symptoms or hypotension at the termina-tion of the treatment session. It may be moreaccurately deﬁned as the weight at which there isno excess extracellular hydration in the tissues. Theaccurate assessment of patient dry weight can poseconsiderable difﬁculties due to the shape of thepressure–volume curve of the interstitial ﬂuid spacessuch that oedema may not be detectable until theinterstitial volume has risen by ;30% above normal,corresponding to 4–5 l. The interdialytic weight gainseen in patients may not simply be a result ofhypervolaemia; gain in body weight as a result ofimproved nutrition, particularly following the initia-tion of regular dialysis therapy, may also contribute.
Structural and magnetic behavior of transition metal doped InN grown by molecular beam epitaxy (2006)

We present growth and characterization of Cr- and Mn-doped InN films grown by plasma-assisted molecular beam epitaxy. The films were deposited on c-plane sapphire substrates, employing GaN intermediate layers to accommodate the lattice mismatch between InN and sapphire. Preliminary studies were also made on growth of Cr-doped InN over (111) GaAs substrates. X-ray diffraction and Hall measurements were used for structural and electrical characterization of the films. The magnetic properties of these materials were measured using superconducting quantum interference device magnetometry. While InN:Mn showed signs of phase segregation and paramagnetism, InN:Cr displayed ferromagnetic properties.
Cloverite: exploring the 30-.ANG. supercage for advanced materials science applications (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCloverite: exploring the 30-.ANG. supercage for advanced materials science applicationsR. L. Bedard, C. L. Bowes, N. Coombs, A. J. Holmes, T. Jiang, S. J. Kirkby, P. M. Macdonald, A. M. Malek, G. A. Ozin, and Cite this: J. Am. Chem. Soc. 1993, 115, 6, 2300–2313Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/ja00059a027https://doi.org/10.1021/ja00059a027research-articleACS PublicationsRequest reuse permissionsArticle Views346Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Method for Determination of Near-wellbore Zone Properties Alteration during Well Drilling, Completion and Cleanup Operations by Combination of Numerical Simulations and Special Experimental Technique (2015)

Abstract Near-wellbore properties can be modified by invaded components of drilling muds or other technological fluids during drilling, completion, and workover operations. At different penetration depths, mud-component invasion creates multizone structures in the vicinity of the wellbore. These structures include external mudcake (mud solid components deposited at the sandface), internal mudcake (which is formed by mud components invaded into the reservoir formation), and mud-filtrate invaded zones. We suggest a model which is able to reproduce the dynamics of near-wellbore zone properties due to the invasion and removal of mud components. The model includes external mud cake buildup and lift-off processes, dynamics of internal mud cake, invasion of the mud filtrate. A new technique is suggested for estimating empirical parameters of both external and internal mudcakes by combining laboratory mud filtration experiments with core samples and a profile of invaded mud components reconstructed by X-ray microCT, image processing of a cleaved sample, and ultrasonic wave scanning. Examples of reconstructed profiles of invaded mud components (solid particles and bentonite clay) as well as the procedure of determining internal mudcake parameters are discussed. A sensitivity study of the characteristics of mud invasion and early production stage is carried out to the properties of reservoir, external and internal mud cake and perforation length. The effects of fines migration and wettability alterations on dynamics of early production stage are simulated. It is shown that modification of properties of near-wellbore zone can significantly increase the final skin-factor and even kill the productivity of some formation layers that is especially applicable to the open-hole completion.
Substantial Fat Loss in Physique Competitors Is Characterized by Increased Levels of Bile Acids, Very-Long Chain Fatty Acids, and Oxylipins (2022)

Weight loss and increased physical activity may promote beneficial modulation of the metabolome, but limited evidence exists about how very low-level weight loss affects the metabolome in previously non-obese active individuals. Following a weight loss period (21.1 ± 3.1 weeks) leading to substantial fat mass loss of 52% (−7.9 ± 1.5 kg) and low body fat (12.7 ± 4.1%), the liquid chromatography-mass spectrometry-based metabolic signature of 24 previously young, healthy, and normal weight female physique athletes was investigated. We observed uniform increases (FDR < 0.05) in bile acids, very-long-chain free fatty acids (FFA), and oxylipins, together with reductions in unsaturated FFAs after weight loss. These widespread changes, especially in the bile acid profile, were most strongly explained (FDR < 0.05) by changes in android (visceral) fat mass. The reported changes did not persist, as all of them were reversed after the subsequent voluntary weight regain period (18.4 ± 2.9 weeks) and were unchanged in non-dieting controls (n = 16). Overall, we suggest that the reported changes in FFA, bile acid, and oxylipin profiles reflect metabolic adaptation to very low levels of fat mass after prolonged periods of intense exercise and low-energy availability. However, the effects of the aforementioned metabolome subclass alteration on metabolic homeostasis remain controversial, and more studies are warranted to unravel the complex physiology and potentially associated health implications. In the end, our study reinforced the view that transient weight loss seems to have little to no long-lasting molecular and physiological effects.
Temporal accumulation and localization of isoflurane in the C57BL/6 mouse and assessment of its potential contamination in 19F MRI with perfluoro‐crown‐ether‐labeled cardiac progenitor cells at 9.4 Tesla (2016)

1 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;45:1659-1667.