gebhart/patrepeval huggingface dataset:
Control of anticoagulation with vitamin K antagonists: overestimation of median time in therapeutic range when assessed by linear interpolation (2016)

Patients receiving vitamin K-antagonists are monitored by regular assessment of the International Normalized Ratio (INR). There are two popular methods for therapeutic control of anticoagulation in patient groups: 1) Time in Therapeutic Range (TTR) assessed by linear interpolation of successive INR measurements; 2) the cross-sectional proportion (CSP) of all patients' last INRs within range. The purpose of the present study is to compare the two methods using data from 53 Dutch Thrombosis Centres and to develop a semi-quantitative model for TTR based on different types of INR change. Different groups of around 400,000 patients in four consecutive years were evaluated: patients in the induction phase, short-term, long-term, low-target range, high-target range, receiving either acenocoumarol or phenprocoumon, and performing self-management. Each Centre provided TTR and CSP results for each patient group. TTR and CSP were compared using the Wilcoxon signed-rank test. Separately, we analysed the relationship between consecutive INR results regarding in or out of range and their frequency of occurrence in patients of two different cohorts. Good correlation was observed between TTR and CSP (correlation coefficient 0.694-0.950 in low-target range). In long-term acenocoumarol patients (low-target range) the median TTR was significantly higher than CSP (80.0 % and 78.7 %, respectively; p<0.001). In long-term phenprocoumon patients (low-target range) there was no significant difference between median TTR (83.0 %) and median CSP (82.6 %). In conclusion, the correlation between TTR assessed by linear interpolation and CSP was good. TTR assessed by linear interpolation was higher than CSP in patients on acenocoumarol.
Automotive Power Electronics Roadmap (2008)

Automotive applications for power electronics is increasing rapidly due to the demand for hybrid and future fuel-cell powered vehicles. The power electronic systems are not only required for driving the vehicle but are also used to interface energy storage components and to supply high power auxiliary systems such as active suspension, electric valves and air conditioning units. The automotive industry has specific requirements for its power electronic systems such as a compact design, high reliability, long life time and an extremely low cost to power ratio. The systems are further required to operate over a wide ambient temperature range and with liquid cooling temperatures of typically 105deg C. In a study from the USA FreedomCAR project, it is projected that the required cost of the power electronic systems has to reduce by a factor of three until the year 2020.
015 Evidence of Low Androgenicity and Little Impact on Sexual Function or Activity with Annovera™, a Novel Contraceptive Vaginal System Releasing Segesterone Acetate and Ethinyl Estradiol (2019)

Journal Article 015 Evidence of Low Androgenicity and Little Impact on Sexual Function or Activity with Annovera™, a Novel Contraceptive Vaginal System Releasing Segesterone Acetate and Ethinyl Estradiol Get access S. Parish, S. Parish Weill Cornell Medical College Search for other works by this author on: Oxford Academic Google Scholar J. Simon, J. Simon George Washington University School of Medicine IntimMedicine Specialists Search for other works by this author on: Oxford Academic Google Scholar B. Lynn, B. Lynn SSM Health St. Mary's Hospital Search for other works by this author on: Oxford Academic Google Scholar B. Bernick, B. Bernick TherapeuticMD Search for other works by this author on: Oxford Academic Google Scholar S. Mirkin, S. Mirkin TherapeuticsMD Search for other works by this author on: Oxford Academic Google Scholar R. Sitruk-Ware R. Sitruk-Ware Population Coucil Search for other works by this author on: Oxford Academic Google Scholar The Journal of Sexual Medicine, Volume 16, Issue Supplement_3, June 2019, Pages S7–S8, https://doi.org/10.1016/j.jsxm.2019.03.472 Published: 01 June 2019
Combined PV / Battery Grid Integration with High Frequency Magnetics Enabled Power Electronics. Final Report (2020)

The project developed and demonstrated a new paradigm in the grid integration of hybrid distributed energy resources (DERs) through leveraging multi-port power electronics building blocks for DC side interconnection of solar PV and energy storage prior to inversion and AC grid integration.
Ultrasmall Mode Volumes in Dielectric Optical Microcavities (2005)

We theoretically demonstrate a mechanism for reduction of mode volume in high index contrast optical microcavities to below a cubic half wavelength. We show that by using dielectric discontinuities with subwavelength dimensions as a means of local field enhancement, the effective mode volume (V(eff)) becomes wavelength independent. Cavities with V(eff) on the order of 10(-2)(lambda/2n)(-3) can be achieved using such discontinuities, with a corresponding increase in the Purcell factor of nearly 2 orders of magnitude relative to previously demonstrated high index photonic crystal cavities.
Re: Cancer Cells Promote Survival Through Depletion of the von Hippel-Lindau Tumor Suppressor by Protein Crosslinking (2012)

No AccessJournal of UrologyInvestigative Urology1 Jun 2012Re: Cancer Cells Promote Survival Through Depletion of the von Hippel-Lindau Tumor Suppressor by Protein Crosslinking Anthony AtalaM.D. Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.2504AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Cancer Cells Promote Survival Through Depletion of the von Hippel-Lindau Tumor Suppressor by Protein Crosslinking." The Journal of Urology, 187(6), p. 2276 © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 6June 2012Page: 2276 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Multi-Touch Table System for Medical Visualization: Application to Orthopedic Surgery Planning (2011)

Medical imaging plays a central role in a vast range of healthcare practices. The usefulness of 3D visualizations has been demonstrated for many types of treatment planning. Nevertheless, full access to 3D renderings outside of the radiology department is still scarce even for many image-centric specialties. Our work stems from the hypothesis that this under-utilization is partly due to existing visualization systems not taking the prerequisites of this application domain fully into account. We have developed a medical visualization table intended to better fit the clinical reality. The overall design goals were two-fold: similarity to a real physical situation and a very low learning threshold. This paper describes the development of the visualization table with focus on key design decisions. The developed features include two novel interaction components for touch tables. A user study including five orthopedic surgeons demonstrates that the system is appropriate and useful for this application domain.
3. Ein Rhythmusworkshop als nonverbale traumapädagogische Intervention (2019)

Mit Musik gemeinsam gegen das Trauma: Rhythmisches Musizieren in der Gruppe zielt als nonverbale traumapädagogische Intervention auf die Förderung und Steigerung der (Selbst-)Heilungsressourcen gewalterfahrener und traumatisierter Jugendlicher in der stationären Kinder- und Jugendhilfe.
ChemInform Abstract: STRUCTURAL DETERMINATION AND SYNTHESIS OF A CHEMICAL SIGNAL OF THE MALE STATE AND A POTENTIAL MULTIPURPOSE PHEROMONE OF THE MOUSE MUS MUSCULUS (1984)

Abstract Das Pheromon (I) wird aus dem Urin männlicher Mäuse isoliert und spektroskopisch sowie durch Hydrierung zum bekannten exo‐Brevicomin (II) identifiziert.
Detecting symptoms of diseases in poultry through audio signal processing (2014)

We developed an audio signal processing algorithm that detects rales (gurgling noises that are a distinct symptom of common respiratory diseases in poultry). We derived features from the audio by calculating mel frequency cepstral coefficients (MFCCs), clustering the MFCC vectors, and examining the distribution of cluster indices over a window of time. The features are classified with a C4.5 decision tree. Our training data consisted of eight minutes of manually labeled audio selected from 25 days of continuous recording from a controlled study. The experiment group was challenged with the infectious bronchitis virus and became sick, while the control group remained healthy. We tested the algorithm on the entire dataset and obtained results that match the course of the disease. Algorithms such as this could be used to continuously monitor chickens in commercial poultry farms, providing an early warning system that could significantly reduce the costs incurred from disease.
Evidence of chemical exchange in recombinant Major Urinary Protein and quenching thereof upon pheromone binding (2018)

The internal dynamics of recombinant Major Urinary Protein (rMUP) have been investigated by monitoring transverse nitrogen-15 relaxation using multiple-echo Carr-Purcell-Meiboom-Gill (CPMG) experiments. While the ligand-free protein (APO-rMUP) features extensive evidence of motions on the milliseconds time scale, the complex with 2-methoxy-3-isobutylpyrazine (HOLO-rMUP) appears to be much less mobile on this time scale. At 308K, exchange rates k ex=500-2000sâ1 were typically observed in APO-rMUP for residues located adjacent to a Î²-turn comprising residues 83-87. These residues occlude an entry to the binding pocket and have been proposed to be a portal for ligand entry in other members of the lipocalin family, such as the retinol binding protein and the human fatty-acid binding protein. Exchange rates and populations are largely uncorrelated, suggesting local âbreathing' motions rather than a concerted global conformational change
GaSb on GaAs solar cells Grown using interfacial misfit arrays (Conference Presentation) (2017)

State of the art InGaP2/GaAs/In0.28Ga0.72As inverted metamorphic (IMM) solar cells have achieved impressive results, however, the thick metamorphic buffer needed between the lattice matched GaAs and lattice mismatched InGaAs requires significant effort and time to grow and retains a fairly high defect density. One approach to this problem is to replace the bottom InGaAs junction with an Sb-based material such as 0.73 eV GaSb or ~1.0 eV Al0.2Ga0.8Sb. By using interfacial misfit (IMF) arrays, the high degree of strain (7.8%) between GaAs and GaSb can be relaxed solely by laterally propagating 90° misfit dislocations that are confined to the GaAs-GaSb interface layer. We have used molecular beam epitaxy to grow GaSb single junction solar cells homoepitaxially on GaSb and heteroepitaxially on GaAs using IMF. Under 15-sun AM1.5 illumination, the control cell achieved 5% efficiency with a WOC of 366 mV, while the IMF cell was able to reach 2.1% with WOC of 546 mV. Shunting and high non-radiative dark current were main cause of FF and efficiency loss in the IMF devices. Threading dislocations or point defects were the expected source behind the losses, leading to minority carrier lifetimes less than 1ns. Deep level transient spectroscopy (DLTS) was used to search for defects electrically and two traps were found in IMF material that were not detected in the homoepitaxial GaSb device. One of these traps had a trap density of 7 × 1015 cm-3, about one order of magnitude higher than the control cell defect at 4 × 1016 cm-3.
Vacuum Distillation Refining and Extrusion Process of Magnesium (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Theoretical comparison of the sensitivity of molecular contrast optical coherence tomography techniques (2005)

Molecular contrast optical coherence tomography (MCOCT) is an extension of OCT in which contrast resulting from the interaction of light with a contrast agent, leads to the enhanced visualization of a specific morphology or biochemical process in a target specimen. In order to improve the sensitivity and specificity of MCOCT, several spectroscopic techniques have recently been introduced which depend upon coherent detection of scattered light which has been modified by interaction with the molecules of interest in a sample. These techniques include harmonic generation, coherent anti-Stokes Raman scattering, linear absorption, and several different forms of pump-probe spectroscopy. We have developed a theoretical framework to facilitate the comparison of the sensitivity of different MCOCT techniques. This framework is based upon the observation that since the noise floor is defined by the reference field power in a shot-noise limited OCT system, the relevant comparison among the techniques is isolated to the available molecular contrast signal power and the algorithm used to extract the signal. We have derived theoretical expressions for the signal power and signal-to-noise ratio for the MCOCT techniques described in the literature based on molecular spectroscopy, as well as several new techniques introduced here.
High‐dose, short‐term, anti‐inflammatory treatment with dexamethasone reduces growth and augments the effects of 5‐fluorouracil on dimethyl‐α‐benzanthracene‐induced mammary tumors in rats (2006)

Our data suggest that DXM may be beneficial as an adjuvant to chemotherapy in the treatment of mammary cancer by increasing the uptake of 5-FU in the tumor.
Multimodal browsing of images in Web documents (1999)

In this paper, we describe a system for performing browsing and retrieval on a collection of web images and associated text on an HTML page. Browsing is combined with retrieval to help a user locate interesting portions of the corpus, without the need to formulate a query well matched to the corpus. Multi-modal information, in the form of text surrounding an image and some simple image features, is used in this process. Using the system, a user progressively narrows a collection to a small number of elements of interest, similar to the Scatter/Gather system developed for text browsing. We have extended the Scatter/Gather method to use multi-modal features. With the use of multiple features, some collection elements may have unknown or undefined values for some features; we present a method for incorporating these elements into the result set. This method also provides a way to handle the case when a search is narrowed to a part of the space near a boundary between two clusters. A number of examples illustrating our system are provided.
Ultrafast non-destructive measurement of the quantum state of light using free electrons (2020)

Since the birth of quantum optics, the measurement of quantum states of nonclassical light has been of tremendous importance for advancement in the field. To date, conventional detectors such as photomultipliers, avalanche photodiodes, and superconducting nanowires, all rely at their core on linear excitation of bound electrons with light, posing fundamental restrictions on the detection. In contrast, the interaction of free electrons with light in the context of quantum optics is highly nonlinear and offers exciting possibilities. The first experiments that promoted this direction appeared over the past decade as part of photon-induced nearfield electron microscopy (PINEM), wherein free electrons are capable of high-order multi-photon absorption and emission. Here we propose using free electrons for quantum-optical detection of the complete quantum state of light. We show how the precise control of the electron before and after its interaction with quantum light enables to extract the photon statistics and implement full quantum state tomography using PINEM. This technique can reach sub-attosecond time resolutions, measure temporal coherence of any degree (e.g., g(1), g(2)), and simultaneously detect large numbers of photons with each electron. Importantly, the interaction of the electron with light is non-destructive, thereby leaving the photonic state (modified by the interaction) intact, which is conceptually different from conventional detectors. By using a pulse of multiple electrons, we envision how PINEM quantum detectors could achieve a single-shot measurement of the complete state of quantum light, even for non-reproducible emission events. Altogether, our work paves the way to novel kinds of photodetectors that utilize the ultrafast duration, high nonlinearity, and non-destructive nature of electron-light interactions.
Real time tracking in robot teleoperation system (2002)

The robot teleoperation system based on stereo vision was developed by the State Key Lab of Intelligent Technology and System of Tsinghua University. The paper presents the design frame of the whole system, and describes in detail some of the key design and implementation problems. Finally, the paper analyses the difficulty of applying this technology to virtual reality and augmented reality systems, and some suggestions are provided. The success of this system can contribute to further research on augmented reality.
A 10-Gb/s low-power low-voltage CTLE using gate and bulk driven transistors (2016)

The continuous time linear equalizer (CTLE) which compensates for the high frequency loss of electrical channels is one of the key components in the design of digital serializer / desrializer (SerDes) circuits. A new technique is described to improve the CTLE performance without any area or power overhead. This technique utilizes the bulk pin of transistors as a second gate. The proposed CTLE is designed and simulated in 130 nm CMOS technology. Post-layout simulation results demonstrate that the proposed technique can improve the eye opening of the conventional CTLE by approximately 68% at 10-Gb/s. The proposed CTLE compensates for the 12 dB loss of a 12 inches backplane at 10-Gb/s. The power consumption is only of 4.1 mW and 2 mW for a 1.2 V and 0.7 V power supply, respectively.
Mechanistic Analysis of the “Bottom-Up” Fill in Copper Interconnect Metallization (2009)

Electrodeposition of copper in the presence of a multicomponent additives mixture, consisting of an inhibitor [e.g., poly(ethylene glycol)] and an accelerator [e.g., bis(3-sulfopropyl) disulfide] that is typically used in the "bottom-up" fill of submicrometer vias and trenches on semiconductor wafers, is analyzed. The additives transport, adsorption, and interactions are incorporated in a time-dependent multicomponent model that provides the additives distribution inside the via. The additives distribution is translated into location- and time-dependent copper deposition rates to simulate the via-fill process. All model parameters are based on experimentally measured transient copper deposition kinetics in the presence of additives. The effect of the local area reduction during the via fill on the additives distribution is incorporated into the simulations. The model indicates that the short time scale additives transport and adsorption processes provide a differential additives coverage between the via top and its bottom sufficient to initiate bottom-up growth. The long time-scale accelerator–inhibitor interactions in combination with the local area reduction effects provide further enhancement to the additives-induced differential plating rates. The latter generates the bottom-up deposition necessary for the "void-free" gap fill of high aspect ratio structures.
ChemInform Abstract: Synthesis and Antiarrhythmic Activity of Novel 3‐Alkyl‐1‐(ω‐(4‐((alkylsulfonyl)amino)phenyl)‐ω‐hydroxyalkyl)‐1H‐im# idazolium Salts and Related Compounds. (1987)

Abstract The imidazolium salts (IV), (VI), and (IX) are prepared from the sulfonamides (I), imidazole (V), or aniline (VII) as shown in the reaction scheme.
Surface plasmon absorption in MoS2 and graphene-MoS2 micro-gratings and the impact of a liquid crystal substrate (2018)

The absorption coefficients of a far-infrared wave are calculated at normal incidence for MoS2 and graphene-MoS2 micro-ribbon gratings placed between a nematic LC and an isotropic dielectric medium. Maxima in the absorption spectra, which are related to the excitation of the surface plasmons in micro-ribbons of these gratings, are observed. The spectral position of absorption maxima depends on the grating spacing, micro-ribbon width, and conductivity of the ribbons. The impact of the 2D electron concentration of the MoS2 ribbons on the plasmon bands is different for a MoS2-grating versus a graphene-MoS2 grating. The influence of the LC orientational state on the absorption spectra of the gratings enables the manipulation of the absorption peak magnitude.
Low-dose aluminum and boron implants in 4H and 6H silicon carbide (2001)

Aluminum and boron p-type low-dose implants have been characterized in 4H- and 6H-SiC for anneals from 1300 °C to 1600 °C. In contrast to previous studies of heavily doped p-type layers, here we study more lightly doped layers for use as active regions in high-voltage power devices. Activation rates of the implanted ions, depth profiles from secondary mass ion spectroscopy, and surface roughness data using atomic force microscopy are presented as a function of anneal temperature. The temperature dependence of the free hole density and hole mobility are characterized with Hall effect measurements. For 1600 °C anneals, usable device quality p-type layers are obtained for both SiC polytypes and implant species. For anneals at or below ∼1500 °C, the implanted layers have much higher sheet resistivity due to the presence of unannealed compensating defects. These layers are not device quality. B-implanted layers have higher mobility, while activation of implanted Al is much higher and more uniform. Therefore, boron and aluminum have different advantages and disadvantages as p-type implants in SiC.
Evolutionary computation and evolutionary deep learning for image analysis, signal processing and pattern recognition (2022)

tutorial Share on Evolutionary computation and evolutionary deep learning for image analysis, signal processing and pattern recognition Authors: Mengjie Zhang Victoria University of Wellington, Wellington, New Zealand Victoria University of Wellington, Wellington, New ZealandView Profile , Stefano Cagnoni University of Parma, Parma, Italy University of Parma, Parma, ItalyView Profile Authors Info & Claims GECCO '22: Proceedings of the Genetic and Evolutionary Computation Conference CompanionJuly 2022 Pages 1602–1630https://doi.org/10.1145/3520304.3533636Published:19 July 2022Publication History 0citation24DownloadsMetricsTotal Citations0Total Downloads24Last 12 Months24Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access