gebhart/patrepeval huggingface dataset:
Development of an Annular Combustor Chamber (2013)

To accommodate the customer’s expectations for operational flexibility and low power generation costs, a gas turbine has to be robust, flexible and cost effective. Since its introduction in 1993 and with its more than 7.5 million operating hours and over 54’000 starts, the GT13E2 gas turbine has already demonstrated to be a most flexible and reliable engine. It is being used in connection with many different applications, and meets a very broad range of environment and operation conditions. The GT13E2 upgrade 2012 described in this paper further improves these capabilities. The next generation of GT13E2 combustors is improved for increased lifetime, reduced total life cycle cost and implementation of a low emission dual fuel AEV burner system. The basic design philosophy for the lifetime improvement is adapted from the well-proven GT24 and GT26 annular combustors. The liner segments represent Alstom’s proven technology of sealed TBC coated metallic combustor liners that can expand in their fixations. The application of a thermal barrier coating onto the segments is simple and cost-effective. The design is robust so that the liners have to be checked only at major inspections and are not subject to reconditioning/replacement at hot gas part inspections. The closed-loop cooling arrangement is used for the backside cooling of the hot gas liner segments and to maintain the large structural components at a constant temperature. This combustion segment improvement is combined with the AEV (Advanced EnVironmental) burner. All the mentioned features result in a marked improvement of the operating and cyclic lifetime of the GT13E2 combustor. This paper describes the development and validation process for the implementation of the combustion liner segment technology of the GT13E2. The various design phases from concept development to validation including the generic tests and final engine implementation are described and substantiated.
Measuring Green Space Effects on Attention and Stress in Children and Youth: A Scoping Review (2021)

This scoping review compiles 42 published studies measuring children's attention and/or stress responses to green space settings. Attention and stress outcomes include objective (e.g., physiological) and subjective (rating scale) traditions. Attention studies had two distinct subjective measurement traditions, one measuring ADHD symptoms, the other measuring attention restoration theory constructs. Correlational studies were more likely to use subjective scales for outcomes whereas experimental studies more frequently used objective measures or a mix of objective and subjective measures. Care should be taken when interpreting and extending this literature as the comparability of outcome variables across studies is unclear.
USE OF COAL DRYING TO REDUCE WATER CONSUMED IN PULVERIZED COAL POWER PLANTS (2003)

the superficial air velocity ranging from 0.2 m/s to 1.4 m/s. Drying rate is shown to be a strong function of air velocity, increasing seven-fold from 0.2 m/s to 1.4 m/s. Increases in velocity from 0.75 m/s (minimum fluidization velocity) to 1.4 m/s resulted in a doubling of the drying rate.
Nanoindentation and birefringence measurements on fused silica specimen exposed to low-energy femtosecond pulses (2006)

Femtosecond laser pulses used in a regime below the ablation threshold have two noticeable effects on Fused Silica (a-SiO2): they locally increase the material refractive index and modify its HF etching selectivity. The nature of the structural changes induced by femtosecond laser pulses in fused silica is not fully understood. In this paper, we report on nanoindentation and birefringence measurements on fused silica exposed to low-energy femtosecond laser pulses. Our findings further back the hypothesis of localized densification effect even at low energy regime.
Supplementary Table from KEAP1-Dependent Synthetic Lethality Induced by AKT and TXNRD1 Inhibitors in Lung Cancer (2023)

&lt;p&gt;PDF file, 70K, 3.Summary of synthetic lethality hits/genes.&lt;/p&gt;
Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/ nucleotide inhibitors (2009)

The results of our studies demonstrate that combination treatments can provide enhanced antiviral activity and, when used in conjunction with appropriate metabolic investigations, provide a rational basis for the design and development of combination regimens for treating chronic HBV infection.
Ultrasound B‐scan image simulation, segmentation, and analysis of the equine tendon (2010)

To conclude, this technique may provide a tool for the rapid assessment and characterization of tendon structures to enable clinical identification of the integrity of the SDFT.
Synthesis and Ativiral Activity of 5-(Benzylthio)-4-carbamyl-1,2,3-triazoles Against Human Cytomegalovirus (CMV) and Varicella-zoster Virus (VZV) (2017)

4,5-Bissubstiuted triazoles are active against herpesviruses and the nature and the position of substituents in the benzene ring remarkably affect their activity, such as bromo, cyano and cyanovynil substituents. Future studies should be undertaken to investigate the mechanism of action of these compounds.
Meroterpenes from Dichrostachys cinerea Inhibit Protein Farnesyl Transferase Activity (2010)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionMeroterpenes from Dichrostachys cinerea Inhibit Protein Farnesyl Transferase ActivityChristophe Long, Laurence Marcourt, Roselyne Raux, Bruno David, Christelle Gau, Christophe Menendez, Min Gao, Marie-France Laroche, Philippe Schambel, Clément Delaude, Frédéric Ausseil, Catherine Lavaud, and Georges Massiot*Cite this: J. Nat. Prod. 2010, 73, 6, 1192Publication Date (Web):May 27, 2010Publication History Received3 May 2010Published online27 May 2010Published inissue 25 June 2010https://pubs.acs.org/doi/10.1021/np100294dhttps://doi.org/10.1021/np100294dcorrectionACS PublicationsCopyright © 2010 The American Chemical Society and American Society of Pharmacognosy. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views663Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (38 KB) Get e-AlertscloseSUBJECTS:Hydrocarbons,Peptides and proteins Get e-Alerts
The Scalp (2021)

Hair is made up of a protein called keratin and is produced by keratinocytes in hair follicles found in the dermis. As follicles produce new hair cells, older cells are pushed through the surface of the scalp at a rate of approximately six inches per year. Hair growth and quality of hair can be greatly affected by scalp health – damaged or miniaturised hair follicles cannot efficiently produce hair and will eventually die. The use of topical finasteride has also been studied in recent years amongst men and women with promising preliminary results; significant decrease in scalp and plasma dihydrotestosterone was observed without changes in serum testosterone. Scalp micropigmentation is a form of medical tattooing where tiny dots are placed on the scalp simulating hair follicles. The medical grade ink used in the procedure is placed in the superficial dermis, and results are expected to last between 3 and 7 years.
A dual-mode synchronous/asynchronous CORDIC processor (2004)

For application in a software defined radio, a CORDIC processor has been developed that can operate both in synchronous and asynchronous mode. Each mode of operation has advantages and drawbacks. Depending on the actual application, an optimal trade-off can be achieved by selecting the mode of operation that fits best with system demands. We believe that for a system developer this additional degree of freedom significantly increases the application space. The design has been implemented on a 0.25 /spl mu/m SiGe:C BiCMOS process. Simulation results using post-layout extracted parameters indicate that the design is competitive both with purely synchronous and purely asynchronous implementations.
Motoneuron-Derived Neurotrophin-3 Is a Survival Factor for PAX2-Expressing Spinal Interneurons (2002)

Rat spinal cord interneurons undergo programmed cell death shortly after birth. We investigated here whether cell death of interneurons could be regulated by trophic factors produced by motoneurons, one of their main targets. To test this hypothesis, we studied the effect of the selective destruction of motoneurons on the survival of interneurons in organotypic cultures of embryonic rat spinal cords. Motoneurons were eliminated by an anti-p75(NTR)-specific immunotoxin (192 IgG-saporin). We then observed a decrease of 28% in the number of ventral spinal interneurons immunoreactive (IR) for the homeoprotein PAX2. This was correlated with an increase in the number of apoptotic nuclei in the same area. Because neurotrophin-3 (NT-3) is specifically produced by motoneurons and because interneurons express the NT-3 high-affinity receptor trkC, we examined the role of NT-3 in the survival of PAX2-IR interneurons. Addition of NT-3 to 192 IgG-saporin-treated explants rescued ventral PAX2-IR interneurons. Depletion of secreted NT-3 by anti-NT-3 antibodies induced 66% loss of ventral PAX2-IR interneurons. We conclude that motoneuron-derived NT-3 is a trophic factor for ventral PAX2-IR interneurons.
Single-domain antibody–based noninvasive in vivo imaging of α-synuclein or tau pathology (2023)

Intracellular deposition of α-synuclein and tau are hallmarks of synucleinopathies and tauopathies, respectively. Recently, several dye-based imaging probes with selectivity for tau aggregates have been developed, but suitable imaging biomarkers for synucleinopathies are still unavailable. Detection of both of these aggregates early in the disease process may allow for prophylactic therapies before functional impairments have manifested, highlighting the importance of developing specific imaging probes for these lesions. In contrast to the β sheet dyes, single-domain antibodies, found in camelids and a few other species, are highly specific, and their small size allows better brain entry and distribution than whole antibodies. Here, we have developed such imaging ligands via phage display libraries derived from llamas immunized with α-synuclein and tau preparations, respectively. These probes allow noninvasive and specific in vivo imaging of α-synuclein versus tau pathology in mice, with the brain signal correlating strongly with lesion burden. These small antibody derivatives have great potential for in vivo diagnosis of these diseases.
Enhancement of Drug Accumulation by Andrastin A Produced by Penicillium sp. FO-3929 in Vincristine-resistant KB Cells. (1998)

In the course of our screening for compounds that reverse multidrug resistance, we found that the cytotoxicity of vincristine was enhanced 1.5-20-fold depending on the concentration of andrastin A in vincristine-resistant KB cells (VJ-300). Andrastin A alone had no effect on the growth of drug sensitive KB cells and VJ-300 cells. On the other hand, andrastin A (25 and 50 micrograms/ml) significantly enhanced accumulation of [3H]vincristine in VJ-300 cells. Andrastin A (50 micrograms/ml) completely inhibited the binding of [3H]azidopine to the P-glycoprotein in VJ-300 cells. The result suggests that andrastin A directly interacts with P-glycoprotein and inhibits the efflux of antitumor agents in drug resistant cells.
A high-stringency blueprint of the human proteome (2020)

The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.
New Fluoride Ion Reagent from Pentafluoropyridine. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Skin delivery of hyaluronic acid by the combined use of sponge spicules and flexible liposomes (2019)

We demonstrated that the topical combined use of sponge Haliclona sp. spicules (SHS) and flexible liposomes (FL), referred to as SFLS (SHS-Flexible Liposomes combined System), can result in synergy to improve the skin absorption and deposition of hyaluronic acid (HA), especially in deep skin layers, both in vitro and in vivo. SHS treatment can result in skin micro-channels which are continuous, deep enough (48.6 ± 13.5 μm) and available in large quantities (850 ± 125 micro-channels per mm2). These micro-channels gradually closed up in 120 h and also allowed the intact vesicles of flexible liposomes and vesicle-bound or vesicle-encapsulated HA to penetrate into the skin-deep layers under the driving force of transdermal osmotic gradients. Specifically, SFLS topical application enhanced the penetration of FITC-HA (MW: 250 kDa) into porcine skin in vitro up to 23.2 ± 3.7%, which is 19.4 ± 3.1-fold (p < 0.001) that of a Phosphate Buffered Saline (PBS) group, 3.4 ± 0.5-fold (p < 0.01) that of an SHS group and 3.6 ± 0.6-fold (p < 0.01) that from the combined use of a Dermaroller and flexible liposomes. Moreover, SFLS can lead to significantly enhanced skin deposition of HA in all skin layers, especially in deep skin layers: up to 86.8 ± 4.1% of HA absorbed by skin was accumulated in deep skin layers. The effectiveness of SFLS topical application was also confirmed in vivo by using BALB/c mice. In addition, a skin irritation and toxicity study showed that the SFLS treatment may cause very minimal redness and the skin can recover in a short time. In sum, the combined use of SHS and FL (SFLS) offers a promising strategy to safely and effectively improve the skin delivery of hydrophilic biomacromolecules such as HA.
ChemInform Abstract: Synthesis of α‐, γ‐Phosphorus Functionalized Alkyl Lithium Species; X‐Ray Structures of ((Li(L)(CH2PMeR))2) (L: NNN′N′‐tetramethylethylenediamine (tmen), R: Me or Ph; L: (‐)sparteine, R: Ph) and Cyclic (Li(tmen)(CH(SiMe3)C6H4PPh2‐o)). (1989)

Abstract The title compounds (IV) are dimeric in the solid state, adopting either chair or boat conformation.
The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer (2016)

Understanding the contribution of the AR to the emergence of highly lethal, drug-resistant NEPC is critical for better implementation of current standard-of-care therapies and novel drug design. Our first-in-field data underscore the consequences of potent AR inhibition in prostate tumors, revealing a novel mechanism of AR-dependent control of neuroendocrine differentiation, and uncover BRN2 as a potential therapeutic target to prevent emergence of NEPC. Cancer Discov; 7(1); 54-71. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 1.
A novel wavelet transform-based transient current analysis for fault detection and localization (2005)

Transient current (IDD) testing has been often cited and investigated as an alternative and/or supplement to quiescent current (IDDQ) testing. In this correspondence, we present a novel integrated method for fault detection and localization using wavelet transform-based IDD waveform analysis. The time-frequency resolution property of wavelet transform helps us detect as well as localize faults in digital CMOS circuits. Experiments performed on measured data from a fabricated 8-bit shift register, and simulation data from more complex circuits show promising results for both detection and localization. Wavelet-based detection method shows better sensitivity than spectral and time-domain methods. Effectiveness of the localization method in presence of complex power supply network, measurement noise, and process variation is also addressed.
Performance tests of a novel coaxial tube catheter in anin vitromodel of intracranial cell delivery (2011)

We have tested prototypes of a novel coaxial tube catheter in an in vitro gel model of cell delivery into the brain. Devices 1.6 and 2.0 mm outer diameter were used to deliver PC 12 cells (concentration = 10⁶ cells ml⁻¹ at 1 μl min⁻¹ into a 5 ml sandwich of collagen and 0.1% agarose, with and without follow-on infusions of nerve growth factor (NGF). Post-infusion microscopic imaging (40X) at the infusion sites was then carried out over 7-day periods. The results showed that under these experimental conditions, it was possible to use these catheters to deliver cells without either leakage of trapped air into the gel or reflux of the cell suspension along the catheter insertion track. Differentiation of the NGF-treated cells was observed.
Frequency of flash glucose monitoring and glucose metrics: real-world observational data from Saudi Arabia (2022)

Higher scanning frequency in flash glucose users from Saudi Arabia is associated with lower eA1c, higher TIR, lower glucose variability and less time in hypoglycemia or hyperglycemia.
DPN-Generated Nanostructures as Positive Resists for Preparing Lithographic Masters or Hole Arrays (2006)

Experiments that utilize structures generated by dip-pen nanolithography (DPN) as positive resists for fabricating nanohole arrays and lithographic masters are described. The technique takes advantage of the difference in desorption potentials for patterned structures made from 16-mercaptohexadecanoic acid (MHA) and 1-octadecanethiol (ODT), respectively. In this approach, patterns of MHA on gold are generated by DPN, and surrounding areas are passivated by ODT. Electrochemistry is used to selectively remove the MHA nanofeatures made by DPN. The exposed gold can be used as an electrode to plate silver from solution, generating raised features and structures that can be transferred to PDMS to make a lithographic master, or alternatively, they can be etched to make arrays of nanoholes.
Electrical Control of Debye Screening in Liquid Microchannels for Ionic Separations (2008)

In this work we demonstrate controlled electrostatic depletion and accumulation of liquid ions in microscale channels by applying voltage across a dielectric coating on the channel walls. A 100 muM fluorescent ionic dye (FITC) was flown through a series of oxidized (SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) Si microscale channels (each 10 mum wide, 15 mum deep and 1cm long). Negative and positive voltages on the Si substrate were used to deplete and accumulate the negative fluorescent FITC2" ions, respectively. Theoretically calculated plots were used confirm the experimental results. This ability to screen ionic species based on charge can now be applied towards creating a platform for multidimensional separations (charge, surface energy, size) in a single lab-on-chip format.
Monomer–dimer Equilibrium of the pSC101 RepA Protein (1995)

The pSC101 RepA protein, which is required for plasmid DNA replication, but is inhibitory to replication at high concentration, has been found in both monomeric and dimeric forms. While RepA monomers bind to direct repeat iterons near the pSC101 replication origin, dimers bind to sequences that autoregulate RepA synthesis. We investigated the solution properties of purified RepA protein by analytical ultracentrifugation analysis, and found that RepA exists in Escherichia coli cells in a monomer-dimer equilibrium (Kd = 4 microM), and, moreover, that RepA is primarily in the monomeric form at the concentration (500 molecules per cell; 2 microM) we found by Western blot analysis to occur in cells carrying replicating wild-type pSC101 plasmids. However, at concentrations inhibitory to pSC101 DNA replication, the majority of RepA molecules exist as dimers. Our findings provide experimental support for the proposal that the equilibrium between monomer and dimer forms of RepA has a key role in determining its effect on the replication of pSC101.
High Output Power Near-Ultraviolet and Violet Light-Emitting Diodes Fabricated on Patterned Sapphire Substrates Using Metalorganic Vapor Phase Epitaxy (2003)

Near-Ultraviolet (NUV) and violet light-emitting diodes (LEDs) with an InGaN multi-quantum-well (MQW) structure were fabricated on patterned-sapphire substrate (PSS) using a single growth process of metal-organic vapor phase epitaxy (MOVPE). The PSS with parallel grooves along the <1120>GaN direction or the <1100>GaN direction was fabricated by standard photolithography and subsequent reactive ion etching (RIE). In this study, the PSS with parallel grooves along the <1120>GaN direction was used. The GaN layer grown by lateral epitaxy on a patterned substrate (LEPS) had dislocation density of 1.5×108 cm-2. The LEPS-NUV (or violet)-LED chips were mounted on the Si bases in a flip-chip bonding arrangement. When the LEPS-NUV-LED (the emission peak wavelength λp: 382 nm) was operated at forward-bias current of 20 mA at room temperature, the output power (Ρo) and the external quantum efficiency (ηe) were 15.6 mW and 24%, respectively. When the LEPS-violet-LED (λp: 405 nm) was operated at forward-bias current of 20 mA at room temperature, the output power and the external-quantum efficiency were 26.3 mW and 43%, respectively. The PSS is very effective in reducing the dislocation density and increasing the extraction efficiency in the LEDs because of the scattering of the emission light at the patterned GaN/sapphire interface.
Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective alterations in metabolic pathways (2014)

R118 treatment but not metformin resulted in increased glycolysis and lipolysis in skeletal muscle. In contrast, metformin had a greater impact than R118 on glucose and fat metabolism in liver tissue.