gebhart/patrepeval huggingface dataset:
The Balloon-borne Large Aperture Submillimeter Telescope Observatory (2020)

The BLAST Observatory is a proposed super-pressure balloon-borne polarimeter designed for a future ultra- long duration balloon campaign from Wanaka, New Zealand. To maximize scientific output while staying within the stringent super-pressure weight envelope, BLAST will feature new 1.8m off-axis optical system contained within a lightweight monocoque structure gondola. The payload will incorporate a 300 L <sup>4</sup>He cryogenic receiver which will cool 8,274 microwave kinetic inductance detectors (MKIDs) to 100mK through the use of an adiabatic demagnetization refrigerator (ADR) in combination with a <sup>3</sup>He sorption refrigerator all backed by a liquid helium pumped pot operating at 2 K. The detector readout utilizes a new Xilinx RFSOC-based system which will run the next-generation of the BLAST-TNG KIDPy software. With this instrument we aim to answer outstanding questions about dust dynamics as well as provide community access to the polarized submillimeter sky made possible by high-altitude observing unrestricted by atmospheric transmission. The BLAST Observatory is designed for a minimum 31-day flight of which 70% will be dedicated to observations for BLAST scientific goals and the remaining 30% will be open to proposals from the wider astronomical community through a shared-risk proposals program.
A Cloud Portal Architecture for Large-Scale Application Services (2010)

Application services entail multi-billion dollars of market in IT industry. However, to construct an application service is a labor- intensive and error-prone process. Application services developed through traditional development methods expose the same
A prototype supply current monitor for testing analogue circuits (2002)

This paper presents the design of a unified supply current monitor for the detection of faults in analogue circuits. The emphasis is placed on the design of a monitor with minimum overhead that can be implemented to detect variations in the dynamic supply current. The design of the monitor and the results of using it to detect faults in an analogue circuit in a simulation environment are outlined.
A Retrospective Study on Genetic Heterogeneity within Treponema Strains: Subpopulations Are Genetically Distinct in a Limited Number of Positions (2015)

Heterogeneous sites likely represent both the selection of adaptive changes during infection of the host as well as an ongoing diversifying evolutionary process.
Spectral Study of the Inverse Effect of Metal on the Properties of a Carrier (2020)

The effects of the mutual influence of supported metal nanoparticles and a carrier are considered for different cases where the carrier is a solid acid, a solid base, a semiconductor, or a conducting material. Special attention is given to the inverse side of this mutual influence, i.e., modification of the properties of the carrier itself due to the influence of metal particles, which has virtually not been studied or considered before.
Synthesis and P2Y receptor activity of nucleoside 5′-phosphonate derivatives (2020)

Ribose-based nucleoside 5′-diphosphates and triphosphates and related nucleotides were compared in their potency at the P2Y receptors with the corresponding nucleoside 5′-phosphonate derivatives. Phosphonate derivatives of UTP and ATP activated the P2Y2 receptor but were inactive or weakly active at P2Y4 receptors. Uridine 5′-(diphospho)phosphonate was approximately as potent at the P2Y2 receptor as at the UDP-activated P2Y6 receptor. These results suggest that removal of the 5′-oxygen atom from nucleotide agonist derivatives reduces but does not prevent interaction with the P2Y2 receptor. Uridine 5′-(phospho)phosphonate as well as the 5′-methylphosphonate equivalent of UMP were inactive at the P2Y4 receptor and exhibited maximal effects at the P2Y2 receptor that were ≤50% of that of UTP suggesting novel action of these analogues.
The TNF family member TL1A induces IL-22 secretion in committed human Th17 cells via IL-9 induction (2016)

TL1A contributes to the pathogenesis of several chronic inflammatory diseases, including those of the bowel by enhancing T<sub>H</sub>1, T<sub>H</sub>17, and T<sub>H</sub>2 responses. TL1A mediates a strong costimulation of these T<sub>H</sub> subsets, particularly of mucosal CCR9<sup>+</sup> T cells. However, the signaling pathways that TL1A induces in different T<sub>H</sub> subsets are incompletely understood. We investigated the function of TL1A on human T<sub>H</sub>17 cells. TL1A, together with TGF-β, IL-6, and IL-23, enhanced the secretion of IL-17 and IFN-γ from human CD4<sup>+</sup> memory T cells. TL1A induced expression of the transcription factors BATF and T-bet that correlated with the secretion of IL-17 and IFN-γ. In contrast, TL1A alone induced high levels of IL-22 in memory CD4<sup>+</sup> T cells and committed T<sub>H</sub>17 cells. However, TL1A did not enhance expression of IL-17A in T<sub>H</sub>17 cells. Expression of the transcription factor aryl hydrocarbon receptor, which regulates the expression of IL-22 was not affected by TL1A. Transcriptome analysis of T<sub>H</sub>17 cells revealed increased expression of IL-9 in response to TL1A. Blocking IL-9 receptor antibodies abrogated TL1A-induced IL-22 secretion. Furthermore, TL1A increased IL-9 production by peripheral T<sub>H</sub>17 cells isolated from patients with Crohn's disease. These data suggest that TL1A differentially induces expression of T<sub>H</sub>17 effector cytokines IL-17, -9, and -22 and provides a potential target for therapeutic intervention in T<sub>H</sub>17-driven chronic inflammatory diseases.
Enhancing quality of service provisioning in wireless ad hoc networks using service vector paradigm (2006)

Abstract Emerging real‐time communications and multimedia applications necessitate the provisioning of Quality of Service (QoS) in Internet. Recently, a new concept, referred to as service vector , has been introduced to enhance the end‐to‐end QoS granularity, and at the same time, maintain the simplicity and scalability feature of the current differentiated services (DiffServ) networks. This work extends this concept to wireless ad hoc networks and proposes a cross‐layer architecture based on the combination of delay‐bounded wireless link level scheduling and the network layer service vector concept, resulting in significant power savings and finer end‐to‐end QoS granularity. The impact of various traffic arrival distributions and flows with different QoS requirements on the performance of this cross‐layer architecture is also investigated and evaluated. Copyright © 2006 John Wiley &amp; Sons, Ltd.
Growth mechanisms of highly mismatched AlSb on a Si substrate (2005)

We describe the growth mechanisms of highly mismatched (Δao∕ao=13%) defect-free AlSb on Si(001) substrates. Nucleation occurs during the first few monolayers of AlSb deposition by crystalline quantum dot formation. With continued growth, the islands coalesce into a bulk material with no vertically propagating defects. Strain energy from the AlSb∕Si interface is dissipated by crystallographic undulations in the zinc-blende lattice, as confirmed by high-resolution transmission electron microscopy (TEM) images. Reciprocal space analysis of the TEM images corroborates a crystallographic rotation associated with the undulations. The resulting AlSb material is &amp;gt;98% relaxed according to x-ray diffraction analysis.
Investigating von Kries‐like adaptation using local linear models (2006)

Abstract In this article we explore the conditions under which a von Kries‐like model of color constancy is exact. This investigation is motivated by the fact that in practice the model has been shown to work well for a wide range of imaging devices despite the fact that previous analysis of the necessary and sufficient conditions for the model to work predicts that it should perform poorly for real lights and surfaces. We present a modified theory that reconciles this apparent contradiction and that is based on the observation that von Kries‐like adaptation treats sensor responses independently of one another. Starting from this point we show how to recover, for a single sensor, set of surfaces, and reference illuminant, the set of von Kries illuminants: all lights for which von Kries‐like adaptation is a perfect model of illumination change. To help us in this task we use a linear model of surface reflectance, but importantly, we use a local model, that is, a model derived by looking at reflectance only in the region to which the sensor of interest is sensitive. Adopting such a model and treating sensors independently of one another, we show that our new theory accurately predicts the good practical performance of a von Kries‐like model. © 2006 Wiley Periodicals, Inc. Col Res Appl, 31, 90–101, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/col.20186
Reflectors (2006)

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Liquid Crystal-based Beam Steering Technologies for NASA Applications (2006)

Liquid crystal-based beam steering devices can provide electronic beam scanning to angles above 1 milliradian, sub-microradian beam pointing accuracy, as well as wave-front correction to maintain output optical beam quality. The liquid crystal technology effort will be summarized, and the potential application of the resulting devices to NASA space-based scenarios will be described.
Transcription factor CREB3L1 mediates cAMP and glucocorticoid regulation of arginine vasopressin gene transcription in the rat hypothalamus (2015)

Here we shows that cAMP and glucocorticoid positively and negatively regulate Creb3l1 expression in the rat hypothalamus, respectively, and regulation of cAMP on AVP expression is mediated through CREB3L1. This data provides the connection between CREB3L1, a newly identified transcription factor of AVP expression, with the previously proposed mechanism of Avp transcription which extends our understanding in transcription regulation of Avp in the hypothalamus.
Control of muscle differentiation in BC3H1 cells by fibroblast growth factor and vanadate. (1987)

We have examined the control of actin isoform synthesis by pituitary-derived fibroblast growth factor and serum in BC3H1 cells, a tumor-derived nonfusing muscle cell line. Under differentiating conditions in BC3H1 cells, the synthesis of beta- and gamma-actin ceases, and the rate of alpha-actin synthesis is increased concomitant with cessation of cell growth. Addition of fetal calf serum to differentiated cells reverses the process, whereas the addition of pituitary-derived fibroblast growth factor inhibits synthesis of alpha-actin but fails to induce the synthesis of beta- and gamma-actin. Analysis of RNA from differentiated BC3H1 cells after the addition of fetal calf serum indicated that the serum-induced increase in beta- and gamma-actin synthesis reflected an increase in their mRNA levels. In contrast, the repression of alpha-actin synthesis by fetal calf serum or fibroblast growth factor appears to reflect the translation efficiency of alpha-actin mRNA. Fibroblast growth factor is a competence factor for BC3H1 cells which allows them to progress from G0 4 h into the G1 phase of the cell cycle. In order to understand the nature of the intracellular signals responsible for the effect of fibroblast growth factor, we treated cells with vanadate, a known inhibitor of tyrosine-specific protein phosphatases. Vanadate fully mimics the action of fibroblast growth on actin synthesis and creatine phosphokinase synthesis and causes BC3H1 cells to exit the G0 portion of the cell cycle, as demonstrated by the induction of the c-fos proto-oncogene following addition of serum, vanadate, or bovine pituitary-derived fibroblast growth factor to these cells. We conclude that repression of alpha-actin synthesis and induction of the synthesis of beta- and gamma-actin are under independent control and that the induction of beta- and gamma-nonmuscle actin synthesis following serum addition is independent from movement into the cell cycle, and dependent on as yet unidentified serum components. The rate of synthesis of alpha-actin can be controlled by a defined mitogenic polypeptide fibroblast growth factor, which in short term experiments primarily affects the rate of translation of alpha-actin mRNA. The repression by fibroblast growth factor is most likely due to activation of a tyrosine specific protein kinase(s).
Local Delivery of Anti-Monocyte Chemoattractant Protein-1 by Gene-Eluting Stents Attenuates In-Stent Stenosis in Rabbits and Monkeys (2007)

Strategy of inhibiting the action of MCP-1 with a 7ND gene-eluting stent reduced in-stent neointima formation with no evidence of adverse effects in rabbits and monkeys. The 7ND gene-eluting stent could be a promising therapy for treatment of restenosis in humans.
Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis (2015)

Kallistatin, an endogenous plasma protein, exhibits pleiotropic properties in inhibiting inflammation, oxidative stress and apoptosis, as evidenced in various animal models and cultured cells. Here, we demonstrate that kallistatin levels were positively correlated with the concentration of total protein in bronchoalveolar lavage fluids (BALF) from patients with sepsis-related acute respiratory distress syndrome (ARDS), indicating a compensatory mechanism. Lower ratio of kallistatin to total protein in BALF showed a significant trend toward elevated neutrophil counts (P = 0.002) in BALF and increased mortality (P = 0.046). In lipopolysaccharide (LPS)-treated mice, expression of human kallistatin in lung by gene transfer with human kallistatin-encoding plasmid ameliorated acute lung injury (ALI) and reduced cytokine/chemokine levels in BALF. These mice exhibited attenuated lung epithelial apoptosis and decreased Fas/FasL expression compared to the control mice. Mouse survival was improved by kallistatin gene transfer or recombinant human kallistatin treatment after LPS challenge. In LPS-stimulated A549 human lung epithelial cells, kallistatin attenuated apoptosis, down-regulated Fas/FasL signaling, suppressed intracellular reactive oxygen species (ROS) and inhibited ROS-mediated NF-κB activation and inflammation. Furthermore, LPS-induced apoptosis was blocked by antioxidant N-acetylcysteine or NF-κB inhibitor via down-regulating Fas expression. These findings suggest the therapeutic potential of kallistatin for sepsis-related ALI/ARDS.
High Prevalence of Sleep Apnea Syndrome in Patients With Long-Term Pacing (2007)

In paced patients, there is an excessively high prevalence of undiagnosed SAS (59%). Whether treating SAS would have changed the need for pacing is unknown. Treatment effects should be further evaluated particularly because these patients are less symptomatic than typical SAS patients. In any case, SAS should be systematically searched for in paced patients owing to potential detrimental effects on their cardiovascular evolution.
Factors Affecting Allogeneic Peripheral Blood Stem Cell Mobilization in a Large, Ethnically, Diverse Population. (2007)

Abstract Background: Reliable prediction of peripheral blood stem cell (PBSC) mobilization is useful in allogeneic PBSC transplantation, since yield may impact transplant outcomes and alter the approach to ex-vivo cell processing. Existing models to predict CD34 mobilization conflict and no studies have been conducted in a large, ethnically diverse population. Study Design: We studied 598 consecutive allogeneic PBSC collections performed in normal donors at least 18 years of age between 1999 and 2006. Mobilization consisted of subcutaneous G-CSF at either 10 ug/kg/d or 8 ug/kg/BID followed by large volume leukapheresis (LVL) on day 5. Within this group, 270 donors underwent an additional LVL (mean 12L) to collect lymphocytes within 2 days prior to initiation of mobilization. The lymphocyte collection was performed for potential future donor lymphocyte infusion (DLI). Donor demographics, self-reported ethnic backgrounds, PBSC yields and additional laboratory data were recorded for each procedure. Results: The study included 392 Caucasian (C), 65 African American (AA), 109 Hispanic (H) and 32 Asian Pacific (AP) adult donors (Table 1). There were no differences in gender distribution between groups; C donors were significantly older, while AP donors had lower BMI compared to other groups. Peak peripheral blood CD34 counts after mobilization were significantly lower in C donors compared to AA, H and AP donors (79 vs 105, 94 and 97 cells per uL, p&lt;0.01), and were higher in donors with higher pre-G-CSF platelet counts and higher total doses of G-CSF received. Donors who underwent PBSC collection following a prior lymphapheresis also had significantly higher CD34 counts than donors who did not (95 vs 78 per uL, p&lt;0.002). In multivariate analysis, ethnicity, total G-CSF dose, pre-G-CSF platelet count, and performance of prior LVL for DLI collection were significantly associated with CD34 mobilization. Conclusion: This study provides new information on factors which impact CD34 mobilization, which may be of potential benefit during planning for PBSC collection and subsequent cell processing. Table 1. Donor demographics, peripheral blood CD34 counts and CD34 yields Characteristic All Caucasian African−American Hispanic Asian−Pacific P* *For ANOVA comparison among all groups. **Absolute number of circulating CD34 cells in peripheral blood per uL measured after 5 days of G-CSF mobilization and prior to apheresis. *** Total CD34 yield per Liter processed during LVL N 598 392 65 109 32 % Male 51 51 52 50 50 ns Age (yrs) 40 ±13 43 ±13 38±10 35±12 36±12 &lt;0.05 Weight (kg) 79±18 80±19 82±16 75±17 68±16 &lt;0.01 Height (cm) 170±10 172±10 172±10 166±10 166±11 &lt;0.05 BMI (kg/m2) 27±5 27±5 28±5 27±5 25±5 &lt;0.05 Peripheral blood CD34 (per uL)** 86±52 79±49 105±58 94±49 97±73 &lt;0.01 CD34 yield (106/L)*** 35±22 33±21 43±27 35±20 37±25 &lt;0.01
Optimal DoF region of the K-User MISO BC with Partial CSIT (2017)

We consider the $K$-User Multiple-Input-Single-Output (MISO) Broadcast Channel (BC) where the transmitter, equipped with $M$ antennas, serves $K$ users, with $K \leq M$. The transmitter has access to a partial channel state information of the users. This is modelled by letting the variance of the Channel State Information at the Transmitter (CSIT) error of user $i$ scale as $O(P^{-α_i}$) for the Signal-to-Noise Ratio (SNR) $P$ and some constant $α_i \geq 0$. In this work we derive the optimal Degrees-of-Freedom (DoF) region in such setting and we show that Rate-Splitting (RS) is the key scheme to achieve such a region.
ChemInform Abstract: High Asymmetric Induction in the Chiral Hydroboration of Trans Alkenes with Isopinocampheylborane. Evidence for a Strong Steric Dependence in Such Asymmetrie Hydroborations. (1982)

Abstract Die asymmetrische Induktion bei der Hydroborierung von Olefinen durch die Borane (I) bzw. (II) wird untersucht.
Photocatalytic removal of hazardous dye from water using nanostructured WO<SUB align=right>3 (2011)

Nanoparticles of WO 3 were synthesised using precipitation method. A special photo-reactor was designed for water purification using local resources. Laser enhanced photo-degradation for efficient removal of poisonous substances like dye (alizarin yellow GG) present in waste water was carried out using as synthesised WO 3 by irradiating with a 355 nm radiation generated from third harmonic of Nd: YAG laser. The effect of initial concentration of dye, catalyst concentration, and laser light intensity on removal efficiency of dye was investigated. Almost 100% degradation was achieved using nanostructured WO 3 in short span of time which is not possible with microstructure WO 3 catalysts and using conventional custom made setups. To the best of our knowledge, this is a first study of its kind where laser and nano particles WO 3 have been utilised together for removal of the dye.
TRPM8 Biology and Medicinal Chemistry (2011)

TRPM8 belongs to the TRPM Melastatin subfamily of Transient Receptor Potential (TRP) ion channels. Activated by cool temperatures and mimetic ligands, such as menthol and icilin, TRPM8 has been shown to play a role in thermoreception and is expressed in peripheral nerves. TRPM8 is also expressed in other tissues which are not exposed to temperature fluctuations, such as the prostate. The recent advancement of a TRPM8 agonist into the clinic for the treatment of prostate cancer suggests that the channel plays a role in some human pathologies. As more drug-like and selective agonists and antagonists of TRPM8 become available, in vivo pharmacology studies will complement already published knockout data to further our understanding of the role of TRPM8 in human disease.
Introducing the Health Coach at a Primary Care Practice: A Pilot Study (2011)

It is well known that the cost of healthcare in US is a poor value proposition. One of the primary goals of the healthcare reform act is to reduce cost while improving healthcare quality. We believe that adding a health coach will help in achieving this goal. In part I, we discussed the role of a health coach in the healthcare field. In this part, we present the findings from a pilot study at a primary care practice managing diabetes of patients using a health coach. The findings from the study suggest that adding a health coach helps in cost savings as well as improved health for the patients.
An Integrated Framework for Field Recording, Localization, Classification and Annotation of Birdsongs Using Robot Audition Techniques — Harkbird 2.0 (2019)

Bird vocalizations are one of the important subjects in ecoacoustics because birds communicate diversely using various vocalizations such as songs and calls. We have developed a portable system, HARKBird to provide a basic function, i.e., birdsong localization, which automatically extracts sound sources and their direction of arrivals (DOA) using robot audition techniques based on HARK. In this paper, we introduce HARKBird 2.0 which is empowered for higher understanding of birdsongs. A new soundscape annotation tool for localization results is enhanced by an interactive interface for song classification based on an unsupervised feature mapping t-SNE. We show that HARKBird 2.0 provides bird researchers with an integrated framework to analyze spatio-spectro-temporal dynamics of birdsongs using the song analysis of Japanese bush warbler (Horornis diphone).
New algorithm for generator differential protection (2004)

A new algorithm for stator differential protection is presented. The algorithm addresses extreme cases of current transformer saturation, including both AC saturation under large currents and DC saturation under small but DC offset currents. While ensuring good sensitivity and excellent security, the trip time of the actual relay hardware implementing the presented algorithm is below one power cycle.