gebhart/patrepeval huggingface dataset:
Backhaul-Constrained Multicell Cooperation Leveraging Sparsity and Spectral Clustering (2015)

Multicell cooperative processing with limited backhaul traffic is studied for cellular uplinks. Aiming at reduced backhaul overhead, a sparse multicell linear receive-filter design problem is formulated. Both unstructured distributed cooperation and clustered cooperation, in which base station groups are formed for tight cooperation, are considered. Dynamic clustered cooperation, where the sparse equalizer and the cooperation clusters are jointly determined, is solved via alternating minimization based on spectral clustering and group-sparse regression. Furthermore, decentralized implementations of both unstructured and clustered cooperation schemes are developed for scalability, robustness, and computational efficiency. Extensive numerical tests verify the efficacy of the proposed methods.
IND-Enabling Studies for a Clinical Trial to Genetically Program a Persistent Cancer-Targeted Immune System (2019)

PURPOSE:To improve persistence of adoptively transferred T cell receptor (TCR)-engineered T cells and durable clinical responses, we designed a clinical trial to transplant genetically-modified hematopoietic stem cells (HSCs) together with adoptive cell transfer (ACT) of T cells both engineered to express an NY-ESO-1 TCR. Here, we report the preclinical studies performed to enable an investigational new drug (IND) application. EXPERIMENTAL DESIGN:HSCs transduced with a lentiviral vector expressing NY-ESO-1 TCR and the PET reporter/suicide gene HSV1-sr39TK and T cells transduced with a retroviral vector expressing NY-ESO-1 TCR were co-administered to myelodepleted HLA-A2/Kb mice within a formal GLP-compliant study to demonstrate safety, persistence and HSC differentiation into all blood lineages. Non-GLP experiments included assessment of transgene immunogenicity and in vitro viral insertion safety studies. Furthermore, GMP-compliant cell production qualification runs were performed to establish the manufacturing protocols for clinical use. RESULTS:TCR genetically-modified and ex vivo cultured HSCs differentiated into all blood subsets in vivo after HSC transplantation, and co-administration of TCR-transduced T cells did not result in increased toxicity. The expression of NY-ESO-1 TCR and sr39TK transgenes did not have a detrimental effect on gene-modified HSCs differentiation to all blood cell lineages. There was no evidence of genotoxicity induced by the lentiviral vector. GMP batches of clinical-grade transgenic cells produced during qualification runs had adequate stability and functionality. CONCLUSION:Co-administration of HSCs and T cells expressing an NY-ESO-1 TCR is safe in preclinical models. The results presented in this manuscript led to the U.S. FDA approval of IND 17471.
ChemInform Abstract: Tetrazoles of Manno‐ and Rhamnofuranoses. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Localization of heart vectors produced by epicardial burns and ectopic stimuli; validation of a dipole ranging method. (1975)

Location of the equivalent cardiac dipole has been estimated but not fully verified in several laboratories. To test the accuracy of such a procedure, injury vectors were produced in 14 isolated, perfused rabbit hearts by epicardial searing. Strongly dipolar excitation fronts were produced in 6 additional hearts by left ventricular pacing. Twenty computer-processed signals, derived from surface electrodes on a spherical electrolyte-filled tank containing the test preparation, were optimally fitted with a locatable cardiac dipole that accounted for over 99% of the root-mean-square surface potential. For the 14 burns (mean radius 5.0 mm), the S-T injury dipole was located 3.4 plus or minus 0.7 (SD) mm from the burn center. For the 6 paced hearts, the dipole early in the ectopic beat was located 3.7 mm (range 2.6 to 4.6 mm) from the stimulating electrode. Phase inhomogeneities within the chamber appeared to have a small but predictable effect on dipole site determination. The study demonstrates that equivalent dipole location can be determined with acceptable accuracy from potential measurements of the external cardiac field.
Spin Hall Magnetoresistance in Metallic Bilayers (2016)

Spin Hall magnetoresistance (SMR) is studied in metallic bilayers that consist of a heavy metal (HM) layer and a ferromagnetic metal (FM) layer. We find a nearly tenfold increase of SMR in W/CoFeB compared to previously studied HM/ferromagnetic insulator systems. The SMR increases with decreasing temperature despite the negligible change in the W layer resistivity. A model is developed to account for the absorption of the longitudinal spin current to the FM layer, one of the key characteristics of a metallic ferromagnet. We find that the model not only quantitatively describes the HM layer thickness dependence of SMR, allowing accurate estimation of the spin Hall angle and the spin diffusion length of the HM layer, but also can account for the temperature dependence of SMR by assuming a temperature dependent spin polarization of the FM layer. These results illustrate the unique role a metallic ferromagnetic layer plays in defining spin transmission across the HM/FM interface.
Ethnic comparisons of the cross‐sectional relationships between measures of body size with diabetes and hypertension (2008)

Recent estimates indicate that two billion people are overweight or obese and hence are at increased risk of cardiovascular disease and its comorbidities. However, this may be an underestimate of the true extent of the problem, as the current method used to define overweight may lack sensitivity, particularly in some ethnic groups where there may be an underestimate of risk. Measures of central obesity may be more strongly associated with cardiovascular risk, but there has been no systematic attempt to compare the strength and nature of the associations between different measures of overweight with cardiovascular risk across ethnic groups. Data from the Obesity in Asia Collaboration, comprising 21 cross-sectional studies in the Asia-Pacific region with information on more than 263,000 individuals, indicate that measures of central obesity, in particular, waist circumference (WC), are better discriminators of prevalent diabetes and hypertension in Asians and Caucasians, and are more strongly associated with prevalent diabetes (but not hypertension), compared with body mass index (BMI). For any given level of BMI, WC or waist:hip ratio, the absolute risk of diabetes or hypertension tended to be higher among Asians compared with Caucasians, supporting the use of lower anthropometric cut-points to indicate overweight among Asians.
HIV-1 cellular and tissue replication patterns in infected humanized mice (2016)

Humanized mice have emerged as a testing platform for HIV-1 pathobiology by reflecting natural human disease processes. Their use to study HIV-1 biology, virology, immunology, pathogenesis and therapeutic development has served as a robust alternative to more-well developed animal models for HIV/AIDS. A critical component in reflecting such human pathobiology rests in defining the tissue and cellular sites for HIV-1 infection. To this end, we examined the tissue sites for viral infection in bone marrow, blood, spleens, liver, gut, brain, kidney and lungs of human CD34+ hematopoietic stem cell engrafted virus-infected NOD.Cg-Prkdc(scid) Il2rg(tm1Wjl)/SzJ mice. Cells were analyzed by flow cytometry and sorted from species mixtures defined as CD34+ lineage negative progenitor cells, CD14+CD16+ monocyte-macrophages and central, stem cell and effector memory T cells. The cell distribution and viral life cycle were found dependent on the tissue compartment and time of infection. Cell subsets contained HIV-1 total and integrated DNA as well as multi-spliced and unspliced RNA in divergent proportions. The data support the idea that humanized mice can provide a means to examine the multifaceted sites of HIV-1 replication including, but not limited to progenitor cells and monocyte-macrophages previously possible only in macaques and human.
A Model of the Human Spine: Forward and Inverse Kinematics (1992)

Abstract The human spine is a sophisticated mechanism consisting of 24 vertebrae which are arranged in a series-chain between the pelvis and the skull. By careful articulation of these vertebrae, a human being achieves fine motion of the skull. The spine can be modeled as a series-chain with 24 rigid links, the vertebrae, where each vertebra has three degrees-of-freedom relative to an adjacent vertebra. From the studies in the literature, the vertebral geometry and the range of motion between adjacent vertebrae are well-known. The objectives of this paper are to present a kinematic model of the spine using the available data in the literature and an algorithm to compute the inter vertebral joint angles given the position and orientation of the skull. This algorithm is based on the observation that the backbone can be described analytically by a space curve which is used to find the joint solutions..
HIV coreceptor CXCR4 antagonists (2006)

In this review we focus on the chemokine receptor inhibitors targeting CXCR4, which is one of the main HIV coreceptors, besides CCR5, for viral entry.
Stem-cell-associated structural and functional plasticity in the aging hippocampus. (2008)

Aging frequently leads to a functional decline across multiple cognitive domains, often resulting in a severe reduction in life quality and also causing substantial care-related costs. Understanding age-associated structural and functional changes of neural circuitries within the brain is required to improve successful aging. In this review, the authors focus on age-dependent alterations of the hippocampus and the decline of hippocampal function, which are critically involved in processes underlying certain forms of learning and memory. Despite the dramatic reductions in hippocampus-dependent function that accompany advancing age, there is also striking evidence that even the aged brain retains a high level of plasticity. Thus, one promising avenue to reach the goal of successful aging might be to boost and recruit this plasticity, which is the interplay between neural structure, function, and experience, to prevent age-related cognitive decline and age-associated comorbidities.
An adaptive blind SIMO identification approach to joint multichannel time delay estimation (2004)

Time delay estimation (TDE) is a difficult problem in a reverberant environment and the traditional generalized cross-correlation (GCC) methods perform poorly. The adaptive eigenvalue decomposition (AED) algorithm recently proposed by the authors exploits a blind channel identification (BCI) technique and deals with room reverberation more effectively. The AED algorithm was developed for a two-channel system. It requires that the two channels do not share any common zeros (a necessary condition of system identifiability). We generalize the AED algorithm to multichannel (more than 2) systems. Compared to the AED algorithm, the generalized method is more robust since it is less likely for all channels to share a common zero when more sensors are used.
Extractive Catalytic Oxidative Denitrogenation of Fuels and Their Promoting Effect for Desulfurization Catalyzed by Vanadium Substituted Heteropolyacids and Molecular Oxygen (2020)

In this contribution, we successfully apply our recently developed extractive catalytic oxidative desulfurization technology (ECODS) for the removal of different nitrogen-containing compounds (ECODN) from both gasoline and diesel fuels. Hereby, indole, 1-methylindole, 2-methylindole, 3-methylindole, quinoline, and quinaldine are completely removed from different model fuels under oxidative conditions, i.e., 120 °C and 20 bar oxygen, with the use of an aqueous HPA-5 catalyst solution within minutes. Indole and quinoline species are oxidized selectively to water-soluble compounds such as acetic acid (6–16%), formic acid (4–13%), and oxalic acid (0–4%), which are extracted in situ into the aqueous catalyst solution. Moreover, mainly carbon dioxide (71–86%) is formed in the gas phase. Our catalyst system is also very effective for denitrogenation at ambient conditions. In contrast to the removal of N-compounds at 120 °C and 20 bar oxygen, the reaction at 25 °C and atmospheric pressure produces solid N-containing compounds. By combining ECODS and ECODN in one vessel, desulfurization and denitrogenation of different model oils is possible in parallel. Interestingly, N-compounds present in the fuel are found to significantly promote the desulfurization reaction.
Characterization of single-core magnetite nanoparticles for magnetic imaging by SQUID relaxometry (2010)

Optimizing the sensitivity of SQUID (superconducting quantum interference device) relaxometry for detecting cell-targeted magnetic nanoparticles for in vivo diagnostics requires nanoparticles with a narrow particle size distribution to ensure that the Néel relaxation times fall within the measurement timescale (50 ms-2 s, in this work). To determine the optimum particle size, single-core magnetite nanoparticles (with nominal average diameters 20, 25, 30 and 35 nm) were characterized by SQUID relaxometry, transmission electron microscopy, SQUID susceptometry, dynamic light scattering and zeta potential analysis. The SQUID relaxometry signal (detected magnetic moment/kg) from both the 25 nm and 30 nm particles was an improvement over previously studied multi-core particles. However, the detected moments were an order of magnitude lower than predicted based on a simple model that takes into account the measured size distributions (but neglects dipolar interactions and polydispersity of the anisotropy energy density), indicating that improved control of several different nanoparticle properties (size, shape and coating thickness) will be required to achieve the highest detection sensitivity. Antibody conjugation and cell incubation experiments show that single-core particles enable a higher detected moment per cell, but also demonstrate the need for improved surface treatments to mitigate aggregation and improve specificity.
UHF RFID mobile reader for passive- and active-tag communication (2011)

A prototype UHF RFID reader chip for mobile-phone applications was developed. The reader architecture is designed for passive tags in compliance with the ISO/IEC 18000-6 Type C and the EPCglobal Class-1 Generation-2 protocols for UHF RFID air interface. The reader also supports communication with active tags. Experimentally measured performance shows the reader chip achieves very high sensitivities (namely, -86 dBm and -92 dBm) for passive and active RFID systems, respectively. The reader chip, with 1.8-V power supply, was fabricated in a 0.18-μm CMOS process.
Stress Analysis of the Interface Between Cervical Vertebrae End Plates and the Bryan, Prestige LP, and ProDisc-C Cervical Disc Prostheses (2009)

Rigidity of the cores ("nuclei") in Prestige LP and ProDisc-C prostheses guarantee initial maintenance of disc height, but high contact stress takes place at the bone-end plate interface if they are improperly placed or undersized. Anchorage designs add an additional factor that may increase propensity of subsidence, indicated by the high contact stress occurring at the end plate flanges of Prestige LP, and at midline keel fixation on the end plate of ProDisc-C. Although Bryan disc differs in these 2 concerns, it also creates much larger displacement during motion with more variation in disc height that may theoretically increase the load sharing of facet and/or uncovertebral joints compared to more rigid artificial discs.
Development of an Efficient Synthesis of (2-Aminopyrimidin-5-yl) Boronic Acid (2015)

A practical and cost-effective synthesis of (2-aminopyrimidin-5-yl) boronic acid 1b has been developed. Key features of the synthesis include the inexpensive in situ protection of the amine via bis-silylation using TMSCl followed by metal–halogen exchange using n-BuLi and trapping with B(Oi-Pr)3. The water-soluble boronic acid is isolated by a well-designed acid–base sequence providing the target in 80% yield and high purity for the two-step process. The large-scale (15 kg) implementation of a Suzuki–Miyaura borylation to form the pinacol boronic ester is also described.
Supplementary Figure Legends from LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody–Drug Conjugates (2023)

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Ultra-Wideband Antennas: Design and Modeling (2008)

This paper presents an insight into UWB antenna. Aspects regarding design, characterization and modeling of UWB antenna are discussed.
Clinical Variation of Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy (APECED) in a Series of 68 Patients (1990)

To define the clinical picture and course of the autosomal recessive disease called autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), we report data from our 10-month to 31-year follow-up of 68 patients from 54 families, now 10 months to 53 years of age. The clinical manifestations varied greatly and included from one to eight disease components, 63 percent of the patients having three to five of them. The initial manifestation was oral candidiasis in 41 patients (60 percent), intestinal malabsorption in 6 (9 percent), and keratopathy in 2 (3 percent). All the patients had candidiasis at some time. The earliest endocrine component appeared at 19 months to 35 years of age. Hypoparathyroidism was present in 54 patients (79 percent), adrenocortical failure in 49 (72 percent), and gonadal failure in 15 (60 percent) of the female patients greater than or equal to 13 years of age and 4 (14 percent) of the male patients greater than or equal to 16 years of age. There were multiple endocrine deficiencies in half the patients. From 4 to 29 percent of the patients had periodic malabsorption, gastric parietal-cell atrophy, hepatitis, alopecia, vitiligo, or a combination of these conditions. Dental-enamel hypoplasia and keratopathy were also frequent but were not attributable to hypoparathyroidism. In the patients whose initial manifestation (other than candidiasis) was adrenal failure, the other components developed less often than in the remaining patients. We conclude that the clinical spectrum in patients with APECED is broad. The majority of patients have three to five manifestations, some of which may not appear until the fifth decade. Therefore, all patients need lifelong follow-up for the detection of new components of the disease.
Performance of Saphion Type Batteries using SEPARION Separators (2006)

Abstract not Available.
Search for Higgs boson pair production in the two bottom quarks plus two photons final state in $pp$ collisions at $\sqrt{s}=13$ TeV with the ATLAS detector (2022)

Searches are performed for nonresonant and resonant di-Higgs boson production in the $b\bar{b}γγ$ final state. The dataset used corresponds to an integrated luminosity of 139 fb$^{-1}$ of proton–proton collisions at a center-of-mass energy of 13 TeV recorded by the ATLAS detector at the CERN Large Hadron Collider. No excess above the expected background is found and upper limits on the di-Higgs boson production cross sections are set. A 95% confidence-level upper limit of 4.2 times the cross section predicted by the Standard Model is set on $pp→HH$ nonresonant production, where the expected limit is 5.7 times the Standard Model predicted value. The expected constraints are obtained for a background hypothesis excluding $pp→HH$ production. The observed (expected) constraints on the Higgs boson trilinear coupling modifier $κλ$ are determined to be [-1.5,6.7] ([-2.4,7.7]) at 95% confidence level, where the expected constraints on $κλ$ are obtained excluding $pp→HH$ production from the background hypothesis. For resonant production of a new hypothetical scalar particle $X (X → HH → b\bar{b}γγ)$, limits on the cross section for $pp→X→HH$ are presented in the narrow-width approximation as a function of mX in the range 251 GeV$≤mX≤$1000 GeV. The observed (expected) limits on the cross section for $pp→X→HH$ range from 640 fb to 44 fb (391 fb to 46 fb) over the considered mass range.
Alkenes from Terminal Epoxides Using Lithium 2,2,6,6-Tetramethylpiperidide and Organolithiums or Grignard Reagents (2004)

E-Alkenes (including arylated alkenes, dienes, and allylsilanes) are efficiently prepared by alpha-deprotonation of terminal epoxides using lithium 2,2,6,6-tetramethylpiperidide, followed by in situ trapping with organolithiums or Grignard reagents.
Improved Production of l -Threonine in Escherichia coli by Use of a DNA Scaffold System (2012)

Despite numerous approaches for the development of l-threonine-producing strains, strain development is still hampered by the intrinsic inefficiency of metabolic reactions caused by simple diffusion and random collisions of enzymes and metabolites. A scaffold system, which can promote the proximity of metabolic enzymes and increase the local concentration of intermediates, was reported to be one of the most promising solutions. Here, we report an improvement in l-threonine production in Escherichia coli using a DNA scaffold system, in which a zinc finger protein serves as an adapter for the site-specific binding of each enzyme involved in l-threonine production to a precisely ordered location on a DNA double helix to increase the proximity of enzymes and the local concentration of metabolites to maximize production. The optimized DNA scaffold system for l-threonine production significantly increased the efficiency of the threonine biosynthetic pathway in E. coli, substantially reducing the production time for l-threonine (by over 50%). In addition, this DNA scaffold system enhanced the growth rate of the host strain by reducing the intracellular concentration of toxic intermediates, such as homoserine. Our DNA scaffold system can be used as a platform technology for the construction and optimization of artificial metabolic pathways as well as for the production of many useful biomaterials.
Improved hole distribution in InGaN/GaN light-emitting diodes with graded thickness quantum barriers (2013)

InGaN/GaN light-emitting diodes (LEDs) with graded-thickness quantum barriers (GTQB) are designed and grown by metal-organic chemical-vapor deposition. The proposed GTQB structure, in which the barrier thickness decreases from the n-GaN to p-GaN side, was found to lead to an improved uniformity in the hole distribution and thus, radiative recombination rates across the active region. Consequently, the efficiency droop was reduced to 28.4% at a current density of 70 A/cm2, which is much smaller than that of the conventional equal-thickness quantum barriers (ETQB) LED, which is 48.3%. Moreover, the light output power was enhanced from 770 mW for the ETQB LEDs to 870 mW for the GTQB LEDs at 70 A/cm2.
Kinetic model of optical damage in transparent crystals under continuous-wave laser irradiation (2017)

LiNbO<sub>3</sub> and LiTaO<sub>3</sub> are frequently used in second harmonic conversion of continuous-wave light from the infrared to the visible regions. Optical damage of LiNbO<sub>3</sub>-type crystals is a crucial issue in the high-average-power laser systems. The optical damage by a light-induced heating is investigated. We have proposed a light-induced heating by the accumulated long-lived states like polarons or self-trapped excitons. In addition to the long-lived states, point defects as color centers are created by a radiation. A new model includes these states. As a results, it is shown that a creating rate of the color center becomes a important parameter on the determination of critical power.