gebhart/patrepeval huggingface dataset:
Correlation between the emission properties of Sn<sup>2+</sup> center and the chemical composition of ZnO&ndash;P<sub>2</sub>O<sub>5</sub> glasses (2016)

Photoluminescence (PL) properties of Sn-doped zinc phosphate (Sn:xZP) glasses with different chemical compositions are investigated. Sn exists only in the form of Sn2+ in Sn:xZP glasses, which were prepared by a conventional melt-quenching method in Ar atmosphere. The glass-transition temperatures, Tg, of the Sn-doped glasses are lower than that of Sn-free glasses, and the change in the Tg values of Sn-doped glasses increases with increasing ZnO amount. Since the relative ratio of 4-fold coordinated Sn2+ becomes higher with increasing ZnO amount, the coordination state is found to depend significantly on the network structure and not on the optical basicity of the Sn:xZP glasses. The PL bandwidth, indicating the site distribution, becomes narrower as the ZnO amount increases. In addition, the PL decay lifetime in the Zn-rich glass is shorter compared to that of the P2O5-rich glasses, implying that the distribution of Sn2+ is also associated with the network structure. Thus, the network structure of the host matrix rather than the average optical basicity significantly influences the local structure of Sn2+ emission center.
Computer simulations of discharges along insulator surfaces (2017)

Development of streamer discharges in air along surfaces of solid insulators is analyzed by means of computer simulations utilizing drift-diffusion model of charge transport in discharge plasma. The results are presented for smooth cylindrical insulator and insulator with a shed. Variations of electron densities, space charges and electric fields profiles during discharge propagation are reported. The influence of a protective shed on the insulator on the discharge development is highlighted.
Introduction to this special section: Geophysical applications of fiber-optic distributed sensing (2017)

This special section is dedicated to geophysical distributed acoustic sensing (DAS) and distributed temperature sensing (DTS) applications. Since the introduction of commercial DTS units in the 1980s and more recent deployment of DAS in this decade, distributed sensing is quietly revolutionizing sectors of geophysics, particularly those requiring permanent downhole measurements. The common component of distributed sensing technologies is the use of laser scattering measurements on fiber-optic cables (tens of kilometers long) to estimate the physical state of each fiber segment with measurands including temperature (DTS), static strain (DSS), and, most recently, dynamic strain and seismic waves (DAS) recorded either continuously or on an as-needed basis. The high spatial coverage, accuracy, and resolution of this technology make it a truly groundbreaking addition to our subsurface sensing toolbox.
Network Function Offloading Through Classification of Elephant Flows (2020)

With the move from traditional hardware appliance based network functions to Network Function Virtualization, software development is decoupled from the hardware. However, as a network function is no longer optimized for hardware, beneficial features of networking hardware may not be used any more. Solutions such as SDN or NIC offloading aim to overcome this antipodes by integrating networking hardware into the packet processing pipelines. On the one hand, offloading traffic of network functions to hardware can increase throughput and reduce resource consumption. On the other hand, the number of parallel flows in a network can be very high, exhausting the capacity of the tables of the networking hardware and force the system to fall back to software processing. Fortunately, it is known that a large portion of the flows in the Internet are mice flows, whereas the majority of the traffic is constituted by elephant flows. If the elephant flows can be detected efficiently, the hardware tables can be used more efficiently as a larger share of the traffic can be offloaded. We introduce a machine learning based approach that takes its decision with the first packet of a flow. A fundamentally different approach is using packet sampling for the offloading decision. We are evaluating both approaches in terms of complexity, offloaded share of the traffic and table occupation. The results show that a machine learning based offloading decision is possible with the first packet. The sampling approach only reaches a comparable performance at very high sampling rates.
Quantitative Label-Free Characterization of Avidin–Biotin Assemblies on Silanized Glass (2011)

In this study, a time-of-flight secondary ion mass spectrometer TOF-SIMS, operating in the event-by-event bombardment/detection mode was used to characterize avidin-biotin assemblies on silane-modified glass substrates. SIMS was used to analyze several variants of the biointerface, including avidin physically adsorbed on a monofunctional acryl silane surface and covalently attached on monofunctional (amine terminated) and bifunctional (amine and acryl terminated) silanes. The goal of these studies was to determine density of avidin and biotin layers chemically or physically adsorbed on silanized glass substrate. An individual impact of a C(60) projectile used in this study creates a hemispherical crater (∼10 nm in diameter) and emits large numbers of secondary ions from the same nanovolume. Thus, a single impact enables one to unfold distinct secondary ions that span the thickness of the assembled film. This method was used to monitor the presence of glass, silane, and protein ions and to estimate the thickness and density of the avidin layer. In addition, we employed the double coincidence mass spectrometry approach to identify ions coemitted from a specific stratum of the biointerface. This approach was used to determine density of biotin and avidin immobilization while eliminating interferences from isobaric ions that originated from other constituents on the surface. Overall, novel TOF-SIMS quantitative approaches employed here were useful for examining complex biointerfaces and determining both lateral and in depth composition of the film.
The Open Source GAITOR Suite for Rodent Gait Analysis (2018)

Locomotive changes are often associated with disease or injury, and these changes can be quantified through gait analysis. Gait analysis has been applied to preclinical studies, providing quantitative behavioural assessment with a reasonable clinical analogue. However, available gait analysis technology for small animals is somewhat limited. Furthermore, technological and analytical challenges can limit the effectiveness of preclinical gait analysis. The Gait Analysis Instrumentation and Technology Optimized for Rodents (GAITOR) Suite is designed to increase the accessibility of preclinical gait analysis to researchers, facilitating hardware and software customization for broad applications. Here, the GAITOR Suite's utility is demonstrated in 4 models: a monoiodoacetate (MIA) injection model of joint pain, a sciatic nerve injury model, an elbow joint contracture model, and a spinal cord injury model. The GAITOR Suite identified unique compensatory gait patterns in each model, demonstrating the software's utility for detecting gait changes in rodent models of highly disparate injuries and diseases. Robust gait analysis may improve preclinical model selection, disease sequelae assessment, and evaluation of potential therapeutics. Our group has provided the GAITOR Suite as an open resource to the research community at www.GAITOR.org , aiming to promote and improve the implementation of gait analysis in preclinical rodent models.
Metal laminated tooling - A quick and flexible tooling concept (2004)

Using the MELATO® (Metal Laminated Tooling) - technology deep drawing-, stamping- and injection molding tools of various sheet metal materials can be manufactured. The different kinds of stress such as pressure or temperature require adapted connecting technologies. Thus, a temperature-steady connection of the sheet metal lamellas is necessary for injection molds, which can resist the injection pressure. This paper describes the integration of tempering systems in injection molding tools or die casting tools. Related topics such as laser beam welding for bonding and laser beam build-up welding are presented as well.
Platelet‐Derived S100A8/A9 and Cardiovascular Disease in Systemic Lupus Erythematosus (2016)

Platelets contain S100A8/A9 in membrane-enclosed vesicles, enabling rapid cell surface deposition upon activation. Furthermore, platelet S100A8/A9 protein levels were increased in SLE patients, particularly in those with CVD, and may be a future therapeutic target.
Desymmetrization of a Centrosymmetric Molecule by Carbon—Carbon Bond Formation: Asymmetric Aldol Reactions of a Centrosymmetric Dialdehyde. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ultra-wideband active array imaging for biomedical diagnostics (2012)

Ultra-wideband active array imaging has proven extremely valuable for biomedical diagnostics. At the same time, the underlying technologies have achieved a high degree of maturity. Across institutions, we have merged our expertise in M-sequence radar systems, antennas, low-noise and high-power circuitry, to devise an UWB MIMO radar system for breast tumour localisation. Recent progress in UWB imaging and hardware for active antenna arrays is presented.
Hydride sponge: complexation of 1,8-naphthalenediylbis(dimethylborane) with hydride, fluoride, and hydroxide (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydride sponge: complexation of 1,8-naphthalenediylbis(dimethylborane) with hydride, fluoride, and hydroxideHoward Edan KatzCite this: J. Org. Chem. 1985, 50, 25, 5027–5032Publication Date (Print):December 1, 1985Publication History Published online1 May 2002Published inissue 1 December 1985https://pubs.acs.org/doi/10.1021/jo00225a005https://doi.org/10.1021/jo00225a005research-articleACS PublicationsRequest reuse permissionsArticle Views1401Altmetric-Citations171LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Supplementary Figure S3 from MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer (2023)

&lt;p&gt;Peptidyl mimicry of MFF-VDAC1 complex&lt;/p&gt;
Spodoptera frugiperda Caspase-1, a Novel Insect Death Protease That Cleaves the Nuclear Immunophilin FKBP46, Is the Target of the Baculovirus Antiapoptotic Protein p35 (1997)

Employing the degenerate primer-dependent polymerase chain reaction approach used recently to clone human Mch2, we have identified and cloned the insect Spodoptera frugiperda target of the baculovirus antiapoptotic protein p35. This protein named Sf caspase-1 belongs to the family of caspases and is highly related to human Mch3 and CPP32 in sequence and specific activity. The proenzyme of Sf caspase-1 is 299 amino acids in length and can undergo autocatalytic processing in Escherichia coli to an active enzyme heterocomplex. Autoprocessing occurs at Asp-28, Asp-184, and Asp-195 to generate the large p19/p18 and small p12 subunits. Sf caspase-1 is able to induce apoptosis in Sf9 cells and is capable of cleaving p35 to similar sized fragments as observed with extracts from p35 null mutant baculovirus-infected Sf9 cells. Sf caspase-1 activity is potently inhibited by p35, suggesting that it is an important target of this antiapoptotic protein. Finally, the Sf9 nuclear immunophilin FKBP46 was identified as a death-associated substrate for Sf caspase-1.
A “Deep Dive” into the SARS-Cov-2 Polymerase Assembly: Identifying Novel Allosteric Sites and Analyzing the Hydrogen Bond Networks and Correlated Dynamics (2020)

Abstract Replication of the SARS-CoV-2 genome is a fundamental step in the virus life cycle and inhibiting the SARS-CoV2 replicase machinery has been proven recently as a promising approach in combating the virus. Despite this recent success, there are still several aspects related to the structure, function and dynamics of the CoV-2 polymerase that still need to be addressed. This includes understanding the dynamicity of the various polymerase subdomains, analyzing the hydrogen bond networks at the active site and at the template entry in the presence of water, studying the binding modes of the nucleotides at the active site, highlighting positions for acceptable nucleotides’ substitutions that can be tolerated at different positions within the nascent RNA strand, identifying possible allosteric sites within the polymerase structure and studying their correlated dynamics relative to the catalytic site. Here, we combined various cutting-edge modelling tools with the recently resolved SARS-CoV-2 cryo-EM polymerase structures to fill this gap in knowledge. Our findings provide a detailed analysis of the hydrogen bond networks at various parts of the polymerase structure and suggest possible nucleotides’ substitutions that can be tolerated by the polymerase complex. We also report here three “druggable” allosteric sites within the nsp12 RdRp that can be targeted by small molecule inhibitors. Our correlated motion analysis shows that the dynamics within one of the newly identified sites are linked to the active site, indicating that targeting this site can significantly impact the catalytic activity of the SARS-CoV-2 polymerase.
RPGR-Associated Retinal Degeneration in Human X-Linked RP and a Murine Model (2012)

RPGR mutations lead to progressive loss of rod and cone vision, but show different patterns of residual photoreceptor disease expression. Knowledge of the patterns should guide treatment strategies. Rpgr-cko mice had onset of degeneration at relatively young ages and progressive photoreceptor disease. The natural history in this model will permit preclinical proof-of-concept studies to be designed and such studies should advance progress toward human therapy.
IntOpt: In-band Network Telemetry optimization framework to monitor network slices using P4 (2022)

The emergence of Network Functions Virtualization (NFV) is being heralded as an enabler of the recent technologies such as 5G/6G, IoT and heterogeneous networks. Existing NFV monitoring frameworks either do not have the capabilities to express the range of telemetry items needed to perform management or do not scale to large traffic volumes and rates. We present IntOpt, a scalable and expressive telemetry system designed for flexible NFV monitoring using active probing and P4. IntOpt allows us to specify monitoring requirements for individual service chain, which are mapped to telemetry item collection jobs that fetch the required telemetry items from P4 programmable data-plane elements. We propose mixed integer linear program (MILP) as well as a simulated annealing based random greedy (SARG) meta-heuristic approach to minimize the overhead due to active probing and collection of telemetry items. Using P4-FPGA, we benchmark the overhead for telemetry collection. Our numerical evaluation shows that the proposed approach can reduce monitoring overheads by 39% and monitoring delays by 57%. Such optimization may as well enable existing expressive monitoring frameworks to scale for larger real-time networks.
Target classification based on near-distance radar sensors (2004)

Automotive radar systems offer the capability to measure very accurately target range, relative velocity, and azimuth angle of all objects inside the observation area. For future automotive applications like pedestrian safety systems, collision warning, turning-off and lane-changing assistance it will be necessary to have more detailed information about the target type. Therefore, a target classification technique, which is purely based on the range profile measured by a near-distance radar sensor, is presented in this paper.
Intracellular calcium concentrations during metabolic inhibition in the motoneuron cell line NSC-19 (1994)

Changes in the concentrations of intracellular free calcium ([Ca2+]i) and adenine nucleotides were determined in response to metabolic inhibitors in the motoneuron cell line NSC-19. The NADH dehydrogenase inhibitor amobarbital (Amytal) and the mitochondrial uncoupler carbonylcyanide m-chlorophenylhydrazone (CCCP) were used to alter energy metabolism. Exposure of cells to 5 mM Amytal did not significantly change ATP concentrations but produced transient elevations of [Ca2+]i of approximately 80 nM, which were reduced by 32% when cells were studied in Ca(2+)-free solutions. CCCP (10 microM) caused a transient reduction in ATP concentration of 33%. CCCP also produced sustained elevations of [Ca2+]i of about 280 nM, which were reduced by 47% when in Ca(2+)-free solutions. In spite of the sustained elevation of [Ca2+]i induced by CCCP, NSC-19 showed no reduction in cell viability after 48 h compared with controls. Ruthenium red, a blocker of Ca2+ uptake by mitochondria, had little effect on the CCCP-induced [Ca2+]i increment. KCl or glutamate did not produce significant changes in [Ca2+]i, indicating that these cells do not possess significant numbers of voltage-dependent Ca2+ channels or excitatory amino acid receptor-gated channels. [Ca2+]i values in these cells were modified by changes in extracellular Ca2+ concentrations. In Ca(2+)-containing solutions, inhibition of Na+/Ca2+ exchange by amiloride and bepridil led to increased [Ca2+]i, as did blockade of Ca2+ ATPase by vanadate, suggesting that membrane transporters are important in Ca2+ efflux in NSC-19. The present studies indicate that exposure of NSC-19 cells to Amytal and CCCP produces Ca2+ increments by release from internal stores, as well as by transmembrane influx. These results demonstrate that small increments in [Ca2+]i can be produced by metabolic inhibitors or other compounds and that such changes are not associated with immediate cell death. Changes in [Ca2+]i could potentially result in abnormal cell function secondary to altered action of Ca(2+)-dependent enzymes.
ChemInform Abstract: An Efficient Synthesis of 6‐Formyl‐1,2‐dihydro‐2‐oxo‐3‐ pyridinecarboxylic Acid and Some Carbonyl Derivatives of It and Its 6‐ Acetyl Homologue. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A 0.2-V Three-Winding Transformer-Based DCO in 16-nm FinFET CMOS (2020)

In this brief, we introduce a 3.2-4 GHz three-winding transformer-based class-F digitally controlled oscillator (DCO) with a DC-DC booster for energy harvesting applications. A π-model is adopted for this multi-turn transformer to analyze its impedance transformation and overall loop gain. The trifilar coil generates large passive voltage loop gain, allowing the DCO supply voltage of 0.2 V to be even lower than the threshold voltage of transistors without any performance degradation. Due to the gate/drain isolation as well as smaller voltage-dependent capacitance in advanced FinFET technology, this brief achieves very low supply frequency pushing of 38 MHz/V. The switched capacitor placed at the tertiary winding can reach very fine resolution of 1.3 kHz due to the impedance transformations and source degeneration. The bias and control voltages of nearly zero power are generated with a switched-capacitor based DC-DC converter and a ring-based non-overlapped clock generator.
Synthesis, DNA binding affinity and anticancer activity of novel 4H-benzo[g][1,2,3]triazolo[5,1-c][1,4]oxazocines (2016)

A new class of tricyclic heterocycles 4H-benzo[g][1,2,3]triazolo[5,1-c][1,4]oxazocines was synthesized through a Knoevenagel condensation/azide-alkyne cycloaddition reaction cascade in one-pot operation. These eight membered ring containing heterocycles exhibited moderately high anticancer activity against four cancer cell lines; human cervix cancer cell line (HeLa), human prostate cancer cell line (DU145), human breast cancer cell line (MCF-7) and human breast adenocarcinoma epithelial cell line (MDA-MB-231). Our results indicate that these compounds have a weak cytotoxic effect on normal human mammary epithelial cell line (MCF-10A). Cell cycle and apoptosis assay indicate that they inhibit the cell cycle at the G2/M phase and induce apoptosis. Through the RED<sub>100</sub> assay, it is evident that they have potential to inhibit pBR 322 plasmid DNA cleavage by BamH1. UV-visible, fluorescence titration and viscosity studies suggested that these compounds possess DNA binding affinity.
Noise-Controlled Resonance Behavior in Nonlinear Dynamical Systems with Broken Symmetry (1996)

We study noise-controlled resonant behavior in periodically modulated, overdamped bistable dynamic elements subject to a symmetry-breaking dc signal. The spectral amplitudes of the harmonics of the modulation frequency are found to exhibit multiple maxima whose occurrence depends on matchings of deterministic and stochastic time scales; in turn, these times depend on the noise statistics and the degree of asymmetry. We demonstrate the phenomenological results via analytical and numerical computations on an rf SQUID loop, and propose this technique to detect weak signals using a ``frequency hopping'' mechanism to circumvent detector noise limitations.
Supplementary Figure 2 from Polyamine-Blocking Therapy Reverses Immunosuppression in the Tumor Microenvironment (2023)

&lt;p&gt;PDF file - 668K, Central role of arginine metabolism in the immune system and its association with components of inflammatory response.&lt;/p&gt;
EXTEND‐I: safety and efficacy of ranibizumab in Japanese patients with subfoveal choroidal neovascularization secondary to age‐related macular degeneration (2010)

Ranibizumab was effective and well tolerated in Japanese patients with subfoveal CNV secondary to AMD.