gebhart/patrepeval huggingface dataset:
Interactive Laser Cytometric Analysis of Retroviral Protein Expression in HIV-Infected Lymphocytic Cell Lines (1990)

We have used interactive laser cytometry to investigate the expression of human immunodeficiency virus (HIV) envelope glycoproteins gp160, gp41, gp120, and the core protein p24 in the HIV-infected human lymphocyte cell lines H-9, CEM-SS, and C8166. This method allowed for the ultrasensitive detection of fluorescence signals at the single cell level and, when combined with specific anti-HIV antibodies, permitted unique quantitative detection of HIV antigens. Indirect immunofluorescence assays with monoclonal antibodies directed against gp120 revealed that a large proportion of lymphocytic cells expressed increased gp120-associated fluorescence consistent with HTLV-IIIRF infection. Certain monoclonal and polyclonal antibodies were also effective in quantifying gp160, gp41, and p24 expression. Expression of these antigens was found to vary significantly within 48 h. Significant loss (greater than or equal to 50%) of gp120 expression was observed when cells were treated with 1.0 microM AZT. The expression of the HIV-associated protein markers gp160, gp41, and p24 was detectable 24 h after infection of C8166, a cord blood lymphocytic cell line. C8166 cells expressed an additional 6- to 10-fold increase in gp120 in 48 h as well as a 3- to 4-fold increase in gp160, gp41, and p24. AZT (0.01 and 0.1 microM) decreased the expression of gp120, gp160, and p24 in a dose-dependent fashion. This new application of interactive laser cytometry permits early, sensitive, and statistically based distinctions in the expression of HIV-associated antigens in infected target cells at the single-cell level, and allows detection of important changes in HIV-associated antigen expression and the kinectics thereof.(ABSTRACT TRUNCATED AT 250 WORDS)
3rd International Diagnostics Competition– DXC’11 (2011)

We present the third implementation of a framework created jointly by NASA Ames Research Center, Palo Alto Research Center, and Delft University of Technology to compare and evaluate diagnosis algorithms (DAs). This year‟s competition, DXC‟11, introduces a software track in addition to the industrial and synthetic tracks of previous competitions. A total of eleven DAs competed in the three tracks. The paper describes the systems, diagnostic problems of the tracks, fault scenarios, evaluation metrics, participating DAs, results and analysis.
On the "high SNR" assumption in space-time codes designs (2004)

Space-time codes designs commonly rely on the assumption of a high SNR. In this communication, we investigate the impact of this assumption when the channel is correlated. Therefore, we discuss the impact of transmit and receive correlations on the performance of space-time codes as a function of the SNR and the diversity achieved by the codes on independent and identically distributed channels. Full diversity codes are shown not to interact with the channel at high SNRs while at realistic SNRs, interactions occur and affect the coding gain. For non-full diversity codes, interactions with the channel occur whatever the SNR. At realistic SNRs, every space-time code interacts with the channel. While it might be reasonable on independent and identically distributed channels, we show that on correlated channels, the 'high SNR' assumption is totally unrealistic and may lead to bad code designs.
A Comparison of Neutron-Based Non-Destructive Assessment Methods for Chemical Warfare Materiel and High Explosives (2009)

Prompt Gamma Neutron Activation Analysis (PGNAA) systems employ neutrons as a probe to interrogate items, e.g. chemical warfare materiel‐filled munitions. The choice of a neutron source in field‐portable systems is determined by its ability to excite nuclei of interest, operational concerns such as radiological safety and ease‐of‐use, and cost. Idaho National Laboratory’s PINS Chemical Assay System has traditionally used a 252Cf isotopic neutron source, but recently a deuterium‐tritium (DT) electronic neutron generator (ENG) has been tested as an alternate neutron source. This paper presents the results of using both of these neutron sources to interrogate chemical warfare materiel (CWM) and high explosive (HE) filled munitions.
Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3 (2010)

Cholinergic stimulation provokes arrhythmias in this model of LQT3 by triggering bradycardia. beta-Adrenoceptor density is reduced, and beta-adrenoceptor blockade does not prevent arrhythmias. Sodium channel blockade and beta-adrenoceptor stimulation suppress arrhythmias by shortening repolarization and minimizing difference in late sodium current.
Highly regioselective terminal alkyneshydroformylation and Pauson–Khand reaction catalysed by mesoporous organised zirconium oxide based powders (2005)

Zirconia-silica mesoporous powders act as very efficient heterogeneous catalysts for both alkyne hydroformylation and Pauson-Khand reaction and yield regioselectivities opposite to those usually observed.
15O-Water PET Study of the Effect of Imatinib, a Selective Platelet-Derived Growth Factor Receptor Inhibitor, Versus Anakinra, an IL-1R Antagonist, on Water-Perfusable Tissue Fraction in Colorectal Cancer Metastases (2015)

Imatinib increases PTF of colorectal cancer metastases in patients and hence may increase the delivery of antitumor drugs. (15)O-water PET/CT and kinetic modeling provide insights into the microenvironment of human cancers.
GAIT ANALYSIS DRIVEN 2D FINITE ELEMENT MODEL OF THE NEUROPATHIC HINDFOOT (2015)

The diabetic foot is one of the most serious complications of diabetes mellitus and it can lead to foot ulcerations and amputations. Finite element analysis quantifies the loads developed in the different anatomical structures and describes how these affect foot tissue during foot–floor interaction. This approach for the diabetic subjects’ foot could provide valuable information in the process of plantar orthosis fabrication and fit. The purpose of this study was to develop two finite element models of the hindfoot, of healthy and diabetic neuropathic subjects. These models accounts for in vivo kinematics, kinetics, plantar pressure (PP) data and magnetic resonance images. These were acquired during gait analysis on 10 diabetic neuropathics and 10 healthy subjects. Validity of the models has been assessed through comparison between the peak PPs of simulated and experimental data: root mean square error (RMSE) in percentage of the experimental peak value was evaluated. Two different finite elements analysis were performed: subject-specific simulations in terms of both geometry and gait analysis, and by adopting the complete gait analysis dataset as boundary conditions. Model predicted plantar pressures were in good agreement with those experimentally measured. Best agreement was obtained in the subject-specific case (RMSE of 13%).
3D Adaptive Optical Nanoscopy for Thick Specimen Imaging at sub-50 nm Resolution (2020)

Understanding cellular organization demands the best possible spatial resolution in all three dimensions (3D). In fluorescence microscopy, this is achieved by 4Pi nanoscopy methods that combine the concepts of using two opposing objectives for optimal diffraction-limited 3D resolution with switching fluorescent molecules between bright and dark states to break the diffraction limit. However, optical aberrations have limited these nanoscopes to thin samples and prevented their application in thick specimens. Here, we have developed a nanoscope that, by utilizing an advanced adaptive optics strategy, achieves sub-50 nm isotropic resolution of structures such as neuronal synapses and ring canals previously inaccessible in tissue.
AutoMEC (2020)

The 5th generation of the cellular mobile communication system (5G) is in the meantime stepwise being deployed in mobile carriers' infrastructure. Various standardization tracks as well as research activity are investigating the exploitation of the very flexible 5G system architecture for customized deployments, meeting requirements of the vertical industry, such as for automotive, factory, or smart city. A very common base is a cloud-native development and decentralized deployment of the 5G system along with services in distributed resources per the Multi-Access Edge Computing (MEC) architecture to locate services topologically close to (mobile) users, e.g. along public roads, and to enable low-latency communication with local services. Automated management of such a distributed deployment in an agile environment is a prerequisite. This paper investigates the use of Recurrent Neural Networks (RNN) for accurate user mobility prediction in an automotive scenario. By the use of simulated vehicular traffic, a suitable RNN configuration using Long Short-Term Memory (LSTM) has been found, which provides accurate prediction results. Proof of value has been accomplished by an experimental decision algorithm, which balances the use of available distributed resources through service scale, migration or replication decisions while meeting mobile users' expectation on the experienced service quality.
Codificação de Imagens com Predição Adaptativa Baseada no Critério de Mínimos Quadrados (2009)

-Neste artigo, um novo mtodo de predic o baseado no critrio dos mnimos quadrados foi incorporado ao algoritmo MMP (Multidimensional Multiscale Parser), com o objetivo de melhorar seu desempenho segundo um critrio taxa-distorc o. O contexto local usado para ajustar adaptativamente os coeficientes de predic o linear, que incorporam implicitamente as caractersticas da textura local. Uma vez que o decodificador capaz de repetir o procedimento de estimac o dos coeficientes, usando os dados reconstrudos, no necessrio enviar qualquer informac o extra. Este novo modo de predic o linear adaptado ao contexto foi adicionado aos j existentes modos de predic o intra e o melhor modo escolhido atravs da otimizac o do critrio de taxa-distorc o. Resultados experimentais, apresentados nas ltimas sec es deste artigo, mostram que o novo modo de predic o capaz de incorporar ganhos considerveis ao desempenho de codificac o do MMP para imagens suaves, se comparado aos mtodos estadoda-arte baseados em transformada, sem apresentar qualquer perda de desempenho quando usado em imagens no-suaves. Palavras-Chave-Codificac o de imagens, Casamento de padres
Health Problems in Adolescents With Alcohol Use Disorders: Self‐Report, Liver Injury, and Physical Examination Findings and Correlates (2001)

These results indicated that AUDs during adolescence were associated with health problems, including modest but demonstrable liver injury. Self-reported health problems were probably best understood, in this context, as a negative emotionality manifestation.
Residual noise reduction in AlN resonators by prolonged RF excitation (2014)

Very low phase noise oscillators are highly desirable for military radar applications. In order to improve phase noise performance of micro-electro-mechanical-systems (MEMS) oscillators, it is essential to reduce the residual noise of the resonator, which serves as the frequency selective element. The oscillator closed loop phase noise is typically limited by the 1/f flicker noise intrinsic to the MEMS resonator acting as the frequency selective element. In this work, the ability to reduce the 1/f flicker noise and consequently the residual phase noise of 1GHz MEMS aluminum nitride (AlN) contour mode resonators (CMR) by prolonged exposure to RF power at resonant frequency is explored.
Adjuvant Trastuzumab: A Milestone in the Treatment of HER-2-Positive Early Breast Cancer (2006)

Up to one fourth of women diagnosed with early breast cancer (EBC) have tumors that are human epidermal growth factor receptor 2 (HER-2) positive. This is associated with a high risk of relapse and death from meta-static disease. Trastuzumab, a monoclonal antibody directed against the extracellular domain of HER-2, improves survival and quality of life in women with HER-2-positive metastatic breast cancer receiving chemotherapy. Four major adjuvant trials-Herceptin Adjuvant (HERA), National Surgical Adjuvant Breast and Bowel Project (NSABP) B-31, North Central Cancer Treatment Group (NCCTG) N9831, and Breast Cancer International Research Group (BCIRG) 006-including between them >13,000 women with HER-2-positive EBC, have investigated different adjuvant treatment approaches with trastuzumab. These trials have shown that trastuzumab reduces the 3-year risk of recurrence by about half in this population. The benefit was similar across the trials despite differences in patient populations, chemotherapy regimens, and sequencing of treatment. At a 2-year follow-up, interim results from the combined analysis of the NSABP B-31 and NCCTG N9831 trials showed a one third lower mortality for trastuzumab, and there was a trend toward an overall survival benefit in the HERA and BCIRG trials. A small Finnish trial, FinHer, investigating another regimen of trastuzumab, has also shown similarly positive results. Further follow-up of the major adjuvant trials will clarify the survival benefit for women receiving trastuzumab, as well as the optimal treatment duration (1 or 2 years). Notably, cardiac events in the trastuzumab-containing arms of these trials have remained within acceptable levels, with a slightly higher (0.6%-3.3%) incidence of congestive heart failure that mostly responded to treatment. Further follow-up will provide information on long-term cardiac safety. Overall, results from clinical trials are sufficiently compelling to consider 1 year of adjuvant trastuzumab treatment for women with HER-2-positive EBC based on the risk:benefit ratio demonstrated in these studies.
Single molecule sensing with carbon nanotube devices (2013)

Nanoscale electronic devices like field-effect transistors have long promised to provide sensitive, label-free detection of biomolecules. In particular, single-walled carbon nanotubes have the requisite sensitivity to detect single molecule events and sufficient bandwidth to directly monitor single molecule dynamics in real time. Recent measurements have demonstrated this premise by monitoring the dynamic, single-molecule processivity of three different enzymes: lysozyme, protein Kinase A, and the Klenow fragment of DNA polymerase I. In each case, recordings resolved detailed trajectories of tens of thousands of individual chemical events and provided excellent statistics for single-molecule events. This electronic technique has a temporal resolution approaching 1 microsecond, which provides a new window for observing brief, intermediate transition states. In addition, the devices are indefinitely stable, so that the same molecule can be observed for minutes and hours. The extended recordings provide new insights into rare events like transitions to chemically-inactive conformations.
cTBLS: Augmenting Large Language Models with Conversational Tables (2023)

Optimizing accuracy and performance while eliminating hallucinations of open-domain conversational large language models (LLMs) is an open research challenge. A particularly promising direction is to augment and ground LLMs with information from structured sources. This paper introduces Conversational Tables (cTBLS), a three-step architecture to retrieve and generate dialogue responses grounded on retrieved tabular information. cTBLS uses Transformer encoder embeddings for Dense Table Retrieval and obtains up to 125% relative improvement over the retriever in the previous state-of-the-art system on the HyrbiDialogue dataset. cTBLS then uses a shared process between encoder and decoder models to perform a coarse+fine tabular knowledge (e.g., cell) ranking combined with a GPT-3.5 LLM response generator to yield a 2x relative improvement in ROUGE scores. Finally, human evaluators prefer cTBLs +80% of the time (coherency, fluency) and judge informativeness to be 4x better than the previous state-of-the-art.
Demodulate-and-Forward Relaying with Higher Order Modulations: Impact of Channel State Uncertainty (2010)

In this paper, we study the impact of uncertain channel state information (CSI) on the performance of demodulate-and-forward relaying protocols with higher order modulation formats such as pulse-amplitude modulation (PAM) and rectangular quadrature-amplitude modulation (QAM). Assuming a single source and a single destination node assisted by $N$ relay nodes, we study the average bit error probability (BEP) performance of $M$-ary PAM and rectangular QAM constellations with Gray code mapping and imperfect CSI at the relay nodes as well as the destination. The main contributions of this paper are the derivation of closed-form expressions for $a)$ the cumulative distribution functions of the demodulator test statistics, $b)$ the transition probability of error at a given relay, and $c)$ the average BEP for independent and not necessarily identically distributed Rayleigh fading channels with imperfect receiver CSI.
Macromolecular Organization of Chloroplast Membranes (2006)

Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3, 2005
BluePrint molecular subtypes predict response to neoadjuvant pertuzumab in HER2-positive breast cancer (2023)

In patients with HER2-type or HER2-single-type tumors, pertuzumab significantly improved the pCR rate and decreased the risk of breast cancer mortality, which was not observed in other subtypes. BluePrint subtyping may be valuable in future studies to identify patients that are likely to be highly sensitive to HER2-targeting agents.
Divergent Synthesis of Dendronized Poly(p-hydroxystyrene) (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTDivergent Synthesis of Dendronized Poly(p-hydroxystyrene)Scott M. Grayson and Jean M. J. FréchetView Author Information Center for New Directions in Organic Synthesis,† Department of Chemistry, University of California, Berkeley, California 94720-1460, and Materials Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 Cite this: Macromolecules 2001, 34, 19, 6542–6544Publication Date (Web):August 11, 2001Publication History Received23 April 2001Published online11 August 2001Published inissue 1 September 2001https://pubs.acs.org/doi/10.1021/ma010698ghttps://doi.org/10.1021/ma010698grapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views880Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Dendrons,Materials,Organic reactions,Physical and chemical properties,Polymers Get e-Alerts
Structure and Functions of Pediatric Aerodigestive Programs: A Consensus Statement (2018)

Aerodigestive programs provide coordinated interdisciplinary care to pediatric patients with complex congenital or acquired conditions affecting breathing, swallowing, and growth. Although there has been a proliferation of programs, as well as national meetings, interest groups and early research activity, there is, as of yet, no consensus definition of an aerodigestive patient, standardized structure, and functions of an aerodigestive program or a blueprint for research prioritization. The Delphi method was used by a multidisciplinary and multi-institutional panel of aerodigestive providers to obtain consensus on 4 broad content areas related to aerodigestive care: (1) definition of an aerodigestive patient, (2) essential construct and functions of an aerodigestive program, (3) identification of aerodigestive research priorities, and (4) evaluation and recognition of aerodigestive programs and future directions. After 3 iterations of survey, consensus was obtained by either a supermajority of 75% or stability in median ranking on 33 of 36 items. This included a standard definition of an aerodigestive patient, level of participation of specific pediatric disciplines in a program, essential components of the care cycle and functions of the program, feeding and swallowing assessment and therapy, procedural scope and volume, research priorities and outcome measures, certification, coding, and funding. We propose the first consensus definition of the aerodigestive care model with specific recommendations regarding associated personnel, infrastructure, research, and outcome measures. We hope that this may provide an initial framework to further standardize care, develop clinical guidelines, and improve outcomes for aerodigestive patients.
Plastic and Flexible Micro-Electrochemical Supercapacitor Based on Cluster-Assembled Carbon (2015)

Flexible, thin micro-electrochemical supercapacitors (MES) are attracting much attention in electronics for their capability of delivering short power pulses with high stability over repeated charge/discharge cycling. Supersonic Cluster Beam Deposition (SCBD) is an effective strategy for the development of nanostructured, binder-free porous carbon electrodes. It consists in the deposition of low kinetic energy clusters producing films with very low-density and high porosity. The use of SCBD for carbon cluster deposition allows to obtain very high deposition rates and highly collimated beam (divergence &lt;20 mrad) which are suitable for the room temperature deposition of patterned nanostructured films by using stencil masks on a wide variety of substrates including polymers. We exploited SCBD, for the development of a planar, high voltage MES featuring nanostructured carbon electrodes deposited on a flexible plastic Mylar substrate and ionic liquid-based electrolyte. Here, the electrochemical performance at different temperatures of the MES which operate above 2.5 V with a capacitance density approaching approaching 10 F cm -3 ,and delivering 9 mWh cm -3 and 2.5 W cm -3 above room temperature is reported. ACKNOWLEDGMENTS RFO, Ricerca Fondamentale Orientata, is acknowledged for financial support.