gebhart/patrepeval huggingface dataset:
Neumonía adquirida en la comunidad por Staphylococcus aureus resistente a meticilina (2017)

&lt;p&gt;&lt;strong&gt;Resumen&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;Los casos de infecciones causadas por &lt;em&gt;Staphylococcus aureus&lt;/em&gt; resistente a meticilina han aumentado durante la última década. Dentro de ellas, la neumonía necrotizante (NN) adquirida en la comunidad se ha encontrado en pacientes jóvenes, sanos y sin factores de riesgo, lo que ha generado cuadros de evolución rápida y potencialmente mortales. En este artículo se discuten factores epidemiológicos, fisiopatológicos, de diagnóstico, tratamiento y pronóstico de la NN por &lt;em&gt;Staphylococcus aureus&lt;/em&gt; resistente a meticilina adquirida en la comunidad.&lt;/p&gt;
<title>Computer simulation of printed colors on textile materials</title> (1994)

The printing process of textile materials uses an ink set dependent of the image to be printed and referred as the primary color palette. The colors of the printed textile material depend on the printing sequence of the ink masks and are referred as the secondary color palette. A single primary color palette may conduct to different secondary color palettes, as a function of printing sequence. This paper provides an analysis of the mechanism of color appearance on the printed textile materials. The analysis conducts to a model to simulate on the computer display the appearance of the textile printed colors as a function of a number of parameters. The simulation includes a generalized Neugebauer model. A hierarchical structure is introduced for the colors of the secondary palette in order to provide the coefficients of the Neugebauer model. For a certain textile material, the color hierarchy is dependent on the ink set and the printing sequence. The color hierarchy is established as result of color calibration process. Printed samples are used for calibration procedure.
A low-cost smartphone-based platform for highly sensitive point-of-care testing with persistent luminescent phosphors (2017)

Through their computational power and connectivity, smartphones are poised to rapidly expand telemedicine and transform healthcare by enabling better personal health monitoring and rapid diagnostics. Recently, a variety of platforms have been developed to enable smartphone-based point-of-care testing using imaging-based readout with the smartphone camera as the detector. Fluorescent reporters have been shown to improve the sensitivity of assays over colorimetric labels, but fluorescence readout necessitates incorporating optical hardware into the detection system, adding to the cost and complexity of the device. Here we present a simple, low-cost smartphone-based detection platform for highly sensitive luminescence imaging readout of point-of-care tests run with persistent luminescent phosphors as reporters. The extremely bright and long-lived emission of persistent phosphors allows sensitive analyte detection with a smartphone by a facile time-gated imaging strategy. Phosphors are first briefly excited with the phone's camera flash, followed by switching off the flash, and subsequent imaging of phosphor luminescence with the camera. Using this approach, we demonstrate detection of human chorionic gonadotropin using a lateral flow assay and the smartphone platform with strontium aluminate nanoparticles as reporters, giving a detection limit of ≈45 pg mL<sup>-1</sup> (1.2 pM) in buffer. Time-gated imaging on a smartphone can be readily adapted for sensitive and potentially quantitative testing using other point-of-care formats, and is workable with a variety of persistent luminescent materials.
Molecular Conductance Switch-On of Single Ruthenium Complex Molecules (2008)

Thiol-tethered RuII terpyridine complexes were synthesized for a voltage-driven molecular switch and used to understand the switch-on mechanism of the molecular switches of single metal complexes in the solid-state molecular junction in a vacuum. Molecularly resolved scanning tunneling microscopy (STM) images revealed well-defined single RuII complexes isolated in the highly ordered dielectric monolayer. When a negative sample-bias was applied, the threshold voltage to the high conductance state in the molecular junctions of the RuII complex was consistent with the electronic energy gap between the Fermi level of the gold substrate and the lowest ligand-centered redox state of the metal complex molecule. As an active redox center leading to conductance switching in the molecule, the lowest ligand-centered redox state of RuII complexes was suggested to trap an electron injected from the gold substrate. Our suggestions for a single-molecule switch-on mechanism in the solid state can provide guidance in a design that improves the charge-trapping efficiency of the ligands with different metal substrates.
Battery power management in heavy-duty HEVs based on the estimated critical surface charge (2012)

This paper proposes a battery power management strategy using Critical Surface Charge (CSC) information estimated by Extended Kalman Filter (EKF) in real time. The insight from CSC characterisation is used to propose a novel approach for supervisory control design of a series Hybrid Electric Vehicle (HEV). The underlying phenomenon determining the battery allowable power limits is closely connected to the CSC. The estimated CSC is processed with a Finite Impulse Response (FIR) filter to smoothen short-term fluctuations and highlight longer-term trajectories. The battery allowable power limits are adjusted based on the filtered CSC information to prevent undesirable battery operations.
ChemInform Abstract: Arenesulfonylheterocycles. Part 1. Synthesis and Reactions of 2‐Benzenesulfonyl‐4,5‐dichloropyridazin‐3‐ones with Amines. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Integrated Engine and Aircraft Mission Performance Analysis Using NPSS (2012)

An aircraft mission performance module has been developed in NPSS that allows for a collaborative environment for analysis of engine and aircraft mission performance. This model would provide a level of aircraft performance analysis that could be easily customized and exchanged between companies. The model is modular and allows easy integration of the aircraft aerodynamics, mass properties, and any other vehicle specific inputs into a standardized NPSS aircraft element. It also allows for a customizable run input interface that can integrate user input of mission segments, maneuvers, loadings, etc. This model was demonstrated on cases for analyzing different types of flight segments, technology assessment, and engine fault analysis. The creation of modular mission elements allows for quick creation of either standard or custom missions for analysis as well as plug and play capability with native NPSS models. The generic interface between the mission and vehicle make it easy to integrate a variety of engine and airframe models, including models that are not NPSS-based.
Cool and warm hybrid white organic light-emitting diode with blue delayed fluorescent emitter both as blue emitter and triplet host (2015)

A hybrid white organic light-emitting diode (WOLED) with an external quantum efficiency above 20% was developed using a new blue thermally activated delayed fluorescent material, 4,6-di(9H-carbazol-9-yl)isophthalonitrile (DCzIPN), both as a blue emitter and a host for a yellow phosphorescent emitter. DCzIPN showed high quantum efficiency of 16.4% as a blue emitter and 24.9% as a host for a yellow phosphorescent emitter. The hybrid WOLEDs with the DCzIPN host based yellow emitting layer sandwiched between DCzIPN emitter based blue emitting layers exhibited high external quantum efficiency of 22.9% with a warm white color coordinate of (0.39, 0.43) and quantum efficiency of 21.0% with a cool white color coordinate of (0.31, 0.33) by managing the thickness of the yellow emitting layer.
Fluid VolumeConductance forDetermination ofBladder Volume (2006)

Clinical urodynamics isthepresent standard fordiagnosing voiding dysfunction. The nonphysiological nature ofthis examoften hinders symptomreproduction inthelaboratory. Currently, a small intrabladder device isbeing developed toconduct ambulatory urodynamics. Thisstudy investigates the feasibility ofusing fluid volumeconductance forthereal- timeintravesical volumemeasurement needed in urodynamics. Prototype devices arepolymer bodies having 4electrodes. Electrode configurations andprobe geometries weretested inbladder-like latex vessels using saline having conductivity similar tourine. Sensitivity to temperature andfluid concentration weredetermined using fresh pigbladders invitro. Thevoltage across the fluid volumewasfoundtobeinversely related tovolume. Theideal probeconfiguration wasfoundtobean ellipsoid having strip electrodes spaced at250. Increasing fluid temperature andconcentration increased solution conductivity, significantly decreasing themeasured voltage. Urine's dynamic chemical properties therefore necessitate real-time compensation ofconductivity in clinical application; whichcouldbeaccomplished with another smaller electrode array.
Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults (2012)

G protein-coupled receptor kinase 4 (GRK4) with activating polymorphisms desensitize the natriuric renal tubular D1 dopamine receptor, and these GRK4 polymorphisms are strongly associated with salt sensitivity and hypertension. Meanwhile, N-terminal pro-B-type natriuretic peptide (NT-proBNP) may be useful in detecting slight volume expansion. However, relations between hypertension-related gene polymorphisms including GRK4 and cardiovascular indices such as NT-proBNP are not clear, especially in healthy subjects. Therefore, various hypertension-related polymorphisms and cardiovascular indices were analyzed in 97 normotensive, healthy Japanese adults. NT-proBNP levels were significantly higher in subjects with two or more GRK4 polymorphic alleles. Other hypertension-related gene polymorphisms, such as those of renin-angiotensin-aldosterone system genes, did not correlate with NT-proBNP. There was no significant association between any of the hypertension-related gene polymorphisms and central systolic blood pressure, cardioankle vascular index, augmentation index, plasma aldosterone concentration, or an oxidative stress marker, urinary 8-OHdG. Normotensive individuals with GRK4 polymorphisms show increased serum NT-proBNP concentration and may be at a greater risk of developing hypertension and cardiovascular disease.
Energy storage and return in sport surfaces (1999)

The purpose of this paper was to determine the energy input, return and dissipation of sport surfaces using the FE analysis based on actual ground reaction forces. A threedimensional finite element model of an existing running track was created. A viscoelastic material model was implemented using experimentally determined parameters from existing surface samples. Ground reaction forces collected during forefoot running were input into the model and used to determine the associated energetics of the surface. This method has the advantage, over previous experimental methods, of characterising the energy associated with sport surfaces under actual loading conditions experienced during human movement.
Design and synthesis of pyrazole/isoxazole linked arylcinnamides as tubulin polymerization inhibitors and potential antiproliferative agents (2015)

As pyrazole and isoxazole based derivatives are well-known for displaying a considerable biological profile, an attempt has been made to unravel their cytotoxic potential. In this context, a number of pyrazole/isoxazole linked arylcinnamide conjugates (15a-o and 21a-n) have been synthesized by employing a straight forward route. The basic structure comprised three ring scaffolds (A, B and C): methoxyphenyl rings as A and C rings and a five membered heterocyclic ring (pyrazole or isoxazole) as the B-ring. To achieve clear understanding, these derivatives are categorized as pyrazole-phenylcinnamides (PP) and isoxazole-phenylcinnamides (IP). These compounds have been evaluated for their ability to inhibit the growth of various human cancer cell lines such as HeLa, DU-145, A549 and MDA-MB231 and most of them exhibit considerable cytotoxic effects. Some of them like 15a, 15b, 15e, 15i and 15l exhibit promising cytotoxicity in HeLa cells (IC50 = 0.4, 1.8, 1.2, 2.7 and 1.7 μM). Amongst them 15a, 15b and 15e were taken up for detailed biological studies, they were found to arrest the cells in the G2/M phase of the cell cycle. Moreover, they were investigated for their effect on the microtubular cytoskeletal system by using a tubulin polymerization assay, immunofluroscence and molecular docking studies; interestingly they demonstrate a significant inhibition of tubulin polymerization.
Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology (2017)

Epigenetic changes in chromatin structure have been recently associated with the deregulated expression of critical genes in normal and malignant processes. HDAC11, the newest member of the HDAC family of enzymes, functions as a negative regulator of IL-10 expression in APCs, as previously described by our lab. However, at the present time, its role in other hematopoietic cells, specifically in neutrophils, has not been fully explored. In this report, for the first time, we present a novel physiologic role for HDAC11 as a multifaceted regulator of neutrophils. Thus far, we have been able to demonstrate a lineage-restricted overexpression of HDAC11 in neutrophils and committed neutrophil precursors (promyelocytes). Additionally, we show that HDAC11 appears to associate with the transcription machinery, possibly regulating the expression of inflammatory and migratory genes in neutrophils. Given the prevalence of neutrophils in the peripheral circulation and their central role in the first line of defense, our results highlight a unique and novel role for HDAC11. With the consideration of the emergence of new, selective HDAC11 inhibitors, we believe that our findings will have significant implications in a wide range of diseases spanning malignancies, autoimmunity, and inflammation.
Optimal precursor ion selection for LC-MALDI MS/MS (2013)

We present three approaches to precursor ion selection with LC-MALDI MS/MS. Using a well-defined protein standard and a complex human cell lysate, we demonstrate that our methods outperform standard approaches. Our algorithms are implemented as part of OpenMS and are available under http://www.openms.de.
Glutaminolysis is involved in the activation of mTORC1 in in vitro‐produced porcine embryos (2021)

Glutamine supplementation to porcine embryo culture medium improves development, increases leucine consumption, and enhances mitochondrial activity. In cancer cells, glutamine has been implicated in the activation of mechanistic target of rapamycin complex 1 (mTORC1) to support rapid proliferation. The objective of this study was to determine if glutamine metabolism, known as glutaminolysis, was involved in mTORC1 activation in porcine embryos. Culture with 3.75 mM GlutaMAX improved development to the blastocyst stage compared to culture with 1 mM GlutaMAX, and culture with 0 mM GlutaMAX decreased development compared to all groups with GlutaMAX. Ratios of phosphorylated to total MTOR were increased when embryos were cultured with 3.75 or 10 mM GlutaMAX, which was enhanced by the absence of leucine, but ratios for RPS6K were unchanged. As another indicator of mTORC1 activation, colocalization of MTOR and a lysosomal marker was increased in embryos cultured with 3.75 or 10 mM GlutaMAX in the absence of leucine. Culturing embryos with glutaminase inhibitors decreased development and the ratio of phosphorylated to total MTOR, indicating reduced activation of the complex. Therefore, glutaminolysis is involved in the activation of mTORC1 in porcine embryos, but further studies are needed to characterize downstream effects on development.
DNA binding of the Bordetella pertussis H1 homolog alters in vitro DNA flexibility (1996)

BpH1, the Bordetella pertussis H1 homolog, interacts with chromosomal DNA. With DNase I protection assays, we demonstrate in this study that BpH1 binds DNA in a nonspecific manner and that it may cover DNA fragments from end to end. Although the binding was shown to be nonspecific, preferential binding sites and sites resistant to BpH1 binding were identified within and upstream of the pertussis toxin promoter sequence. In the presence of DNA ligase, BpH1 favored the formation of multimeric DNA fragments of various sizes and prevented ring closures, suggesting a diminished flexibility of the DNA fragments and thus indicating that BpH1 acts as a macromolecular crowding agent.
Three-dimensional skyrmions in spin-2 Bose–Einstein condensates (2018)

We introduce topologically stable three-dimensional skyrmions in the cyclic and biaxial nematic phases of a spin-2 Bose-Einstein condensate. These skyrmions exhibit exceptionally high mapping degrees resulting from the versatile symmetries of the corresponding order parameters. We show how these structures can be created in existing experimental setups and study their temporal evolution and lifetime by numerically solving the three-dimensional Gross-Pitaevskii equations for realistic parameter values. Although the biaxial nematic and cyclic phases are observed to be unstable against transition towards the ferromagnetic phase, their lifetimes are long enough for the skyrmions to be imprinted and detected experimentally.
Heuristic methods for the "span elimination" problem in ring-based transport network design (2003)

An aspect that is common to much of the work on optimized design of multiple-ring SONET (or WDM) networks is that they treat the design as a form of graph-covering problem. This produces fully restorable designs but there may be unnecessary lower bounds on network cost when the ring set has strictly to protect every span in the fiber graph. "Span elimination" is the problem of finding those key spans of an existing fiber graph on which it is more effective not to route any demands, thereby avoiding the requirement for ring coverage on the span. Preliminary results, with two algorithms, show significant cost reductions in the designs that emerge from a coverage-based solver arising from judicious span elimination prior to the graph-covering process.
How much feedback is required in MIMO Broadcast Channels? (2007)

In this paper, a downlink communication system, in which a Base Station (BS) equipped with M antennas communicates with N users each equipped with K receive antennas ($K \leq M$), is considered. It is assumed that the receivers have perfect Channel State Information (CSI), while the BS only knows the partial CSI, provided by the receivers via feedback. The minimum amount of feedback required at the BS, to achieve the maximum sum-rate capacity in the asymptotic case of $N \to \infty$ and different ranges of SNR is studied. In the fixed and low SNR regimes, it is demonstrated that to achieve the maximum sum-rate, an infinite amount of feedback is required. Moreover, in order to reduce the gap to the optimum sum-rate to zero, in the fixed SNR regime, the minimum amount of feedback scales as $θ(\ln \ln \ln N)$, which is achievable by the Random Beam-Forming scheme proposed in [14]. In the high SNR regime, two cases are considered; in the case of $K &lt; M$, it is proved that the minimum amount of feedback bits to reduce the gap between the achievable sum-rate and the maximum sum-rate to zero grows logaritmically with SNR, which is achievable by the "Generalized Random Beam-Forming" scheme, proposed in [18]. In the case of $K = M$, it is shown that by using the Random Beam-Forming scheme and the total amount of feedback not growing with SNR, the maximum sum-rate capacity is achieved.
Molecular and functional characterization of a family of rat brain T-type calcium channels. (2001)

Pages 4006–4008, Figs. 6, 7, and 8: There are several errors in these figures.Figure 7Voltage-dependent activation and steady-state inactivation of α1I, α1G, and α1H calcium currents. A, activation curves. The current amplitude was converted to conductance by assuming a calcium reversal potential extrapolated from the linear, positive slope region of the I–V curve. The conductance at each potential was normalized to the maximum conductance and was averaged for each step potential. The symbols represent pooled data from α1I (filled triangles, n = 5), α1G (filled circles, n = 4), and α1H (filled squares, n = 9).Solid lines represent the fitting with Boltzman equations with half-activation voltages (V0.5a) of −60.7, −51.73, and −43.15 mV and slope factors (ka) of 8.39, 6.53, and 5.34 for α1I, α1G, and α1H, respectively. B, steady-state inactivation curves. The membrane potential was stepped to −30 mV from holding potentials ranging from −120 to −50 mV. The normalized peak amplitude of the currents elicited by the test pulse to −30 mV was plotted as a function of the holding potential. These data were fitted with a Boltzman equation (smooth curves). Half-inactivation voltage (V0.5i) and slope factor (ki) were −93.2 mV and 4.7 (n = 6), −85.4 mV and 5.4 (n = 5), and −73.9 mV and 2.76 (n = 4) for α1I (open triangles), α1G (open circles), and α1H (open squares), respectively. C–E, activation and inactivation curves were plotted in the same graphic and expanded to show window currents for each channel: α1I (C), α1G(D), and α1H (E).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 8Voltage dependence of deactivation kinetics. A, plot of mean deactivation time constants (τdeac) against repolarization potentials. Data represent mean and S.E. for the following number of cells: α1I(n = 6), α1G (n = 3), and α1H(n = 4). Deactivation time constants were determined by fitting tail currents (B–D) with a single exponential.B–D, representative calcium current tail traces of α1I (B), α1G (C), and α1H (D). Currents were evoked using the following voltage protocols: a 9-ms step to −40 mV for α1G, a 20-ms step to −50 mV for α1I, and a 6-ms step to −30 mV for α1H followed by repolarization to potentials from −120 to −40 mV.View Large Image Figure ViewerDownload Hi-res image Download (PPT) Figs. 6 and 8: The Greek letter τ was omitted on several of the axes. Fig. 7: The axis labels were omitted. Fig.7 A, the x axis should read Vc(mv) and the y axis normalized conductance. Fig. 7 B, the x axis should readprepulse potential (mv), and the yaxis should read normalized current. Fig. 7,C–E, the x axis should read Vc/prepulse potential (mV), and the y axis should readnormalized conductance/current. Fig. 8: The plot legend should indicate that α1H is labeled as a square and α1I as atriangle. The correct figures and legends are the following.