gebhart/patrepeval huggingface dataset:
Synthesis of functionalised HP-DO3A chelating agents for conjugation to biomolecules (2009)

Two novel bifunctional chelating agents (BFCAs) based on the structure of 10-(2-hydroxypropyl)-1,4,7-tetraazacyclododecane-1,4,7-triacetic acid (HP-DO3A) have been designed and synthesized. BFCAs are able to strongly coordinate metals (e.g. Gd(iii)) and radiometals (e.g.(90)Y(iii), (177)Lu(iii) and (111)In(iii)), and find applications in the synthesis of products for the imaging and treatment of several cancer types. Indeed, these two BFCAs have been employed in solid-phase peptide synthesis (SPPS) and coupled to well-known peptides such as bombesin and RGD analogues in order to target tumor cells. We also report here the conjugation of one of them to Lys(8)-oxytocin and radiolabeling with (111)In(iii) to obtain a new radiopharmaceutical product with potential applications in the diagnosis of tumors over-expressing oxytocin receptors.
Nonlinear Optics: Heterogeneously Integrated GaAs Waveguides on Insulator for Efficient Frequency Conversion (Laser Photonics Rev. 12(10)/2018) (2018)

In article number 1800149, Lin Chang and co-workers demonstrate a gallium-arsenide-on-insulator platform for integrated nonlinear photonics. Waveguides on this platform have high nonlinear coefficients, large index contrasts and low propagation losses. Harnessing those properties, a second harmonic generation with a record normalized efficiency is achieved. This work paves a way to ultra-high performance nonlinear photonic integrated circuits.
Sparsity-based Recovery of Quantum States From Partial Measurements in a Single Setup (2014)

We show that prior knowledge that a state of several photons can be represented in compact form in an unknown basis enables the recovery of the quantum state from partial measurements in a single setup.
Multicenter Investigation of Fungal Infections of Inflatable Penile Prostheses (2019)

Fungal infections represent 12% of all penile prosthesis infections in our series and were seen mostly in diabetic or overweight patients, who may benefit from antifungal prophylaxis. Gross MS, Reinstatler L, Henry GD, et al. Multicenter Investigation of Fungal Infections of Inflatable Penile Prostheses. J Sex Med 2019;16:1100-1105.
Expression of mouse histone genes: transcription into 3' intergenic DNA and cryptic processing sites downstream from the 3' end of the H3 gene. (1987)

Introduction of the mouse histone H3.1 gene into tk- mouse L cells by cotransfection with the herpesvirus thymidine kinase gene resulted in the production of two mRNAs from the transfected gene, one with a normal 3' end and the other one with a longer 3'-untranslated region, ending at site X, which was poly(A)+. In contrast, the endogenous histone H3.1 gene only produced a single mRNA. The cryptic poly(A)+ site was only used when the histone H3.1 gene was transfected. To localize possible downstream cryptic processing sites, the hairpin loop at the end of the histone gene was deleted and the resulting deletions were introduced into L cells. Two major mRNAs were produced from this gene, one ending at site X and the major one ending at site Y, which was located 150 nucleotides before site X. Transcription extended downstream of site X efficiently in the endogenous gene, as judged by the extent of transcription of downstream sequences in isolated nuclei. Transcription extended downstream of site X in the transfected gene because the placement of a normal histone 3' end downstream of site X resulted in transcripts that ended at site X and longer transcripts that ended with the new histone 3' end. These results indicate that transcription may normally proceed a substantial distance past the hairpin loop (greater than 500 bases). The formation of the different 3' ends in these transfected genes was due to competition between different processing mechanisms.
Light-Induced Nanosecond Relaxation Dynamics of Rhenium-Labeled Pseudomonas aeruginosa Azurins (2020)

Time-resolved phosphorescence spectra of Re(CO)<sub>3</sub>(dmp)<sup>+</sup> and Re(CO)<sub>3</sub>(phen)<sup>+</sup> chromophores (dmp = 4,7-dimethyl-1,10-phenanthroline, phen = 1,10-phenanthroline) bound to surface histidines (H83, H124, and H126) of <i>Pseudomonas aeruginosa</i> azurin mutants exhibit dynamic band maxima shifts to lower wavenumbers following 3-exponential kinetics with 1-5 and 20-100 ns major phases and a 1.1-2.5 μs minor (5-16%) phase. Observation of slow relaxation components was made possible by using an organometallic Re chromophore as a probe whose long phosphorescence lifetime extends the observation window up to ∼3 μs. Integrated emission-band areas also decay with 2- or 3-exponential kinetics; the faster decay phase(s) is relaxation-related, whereas the slowest one [360-680 ns (dmp); 90-140 ns (phen)] arises mainly from population decay. As a result of shifting bands, the emission intensity decay kinetics depend on the detection wavelength. Detailed kinetics analyses and comparisons with band-shift dynamics are needed to disentangle relaxation and population decay kinetics if they occur on comparable timescales. The dynamic phosphorescence Stokes shift in Re-azurins is caused by relaxation motions of the solvent, the protein, and solvated amino acid side chains at the Re binding site in response to chromophore electronic excitation. Comparing relaxation and decay kinetics of <b>Re(dmp)124K122Cu</b><sup><b>II</b></sup> and <b>Re(dmp)124W122Cu</b><sup><b>II</b></sup> suggests that electron transfer (ET) and relaxation motions in the W122 mutant are coupled. It follows that nanosecond and faster photo-induced ET steps in azurins (and likely other redox proteins) occur from unrelaxed systems; importantly, these reactions can be driven (or hindered) by structural and solvational dynamics.
Embedded Porous Si Reflectors for Epitaxial Solar Cells: Stability, Optical Performance and Industrial Manufacturability (2010)

The ‘wafer equivalent’ cell concept consists of a thin (~20μm thick) high-quality epitaxial stack on top of a porous Si-based Bragg-type reflector which is electrochemically etched in a non-active, highly-doped low-cost (UMG) silicon substrate. We report here on further investigations of the porous Si layers in terms of stability, optical performance and (industrial) manufacturability. A numerical optical model of the epitaxial thin-film solar cell was constructed. This allows us to accurately assess the optical performance of the porous Si (PSi) Bragg reflector, and to identify/quantify potential routes for improvement. Theoretically, the design of the Bragg reflector currently used can certainly be improved, but is in practice limited by the boundary conditions in terms of maximum porosity and layer thickness. Furthermore, a thorough study of the ‘ageing’ behavior of the as-etched porous layers has been performed. It is revealed that all the microporous Si layers etched in p+ Si substrates exhibit a very stable H-surface passivation. They are chemically and physically stable over a period of several months, demonstrating that the storage time and conditions of PSi layers is non-critical. In addition, imec has been involved in the assessment of a (semi-) industrial, large area porous Si etch reactor with high throughput potential. Resulting PSi layer Bragg reflectors showed satisfying optical properties. All these results significantly contribute to the maturity of the porous Si + epitaxial Si thin-film cell technology, bringing industrial implementation a step closer to reality.
Limited Proteolysis Combined with Stable Isotope Labeling Reveals Conformational Changes in Protein (Pseudo)kinases upon Binding Small Molecules (2015)

Likely due to conformational rearrangements, small molecule inhibitors may stabilize the active conformation of protein kinases and paradoxically promote tumorigenesis. We combined limited proteolysis with stable isotope labeling MS to monitor protein conformational changes upon binding of small molecules. Applying this method to the human serine/threonine kinase B-Raf, frequently mutated in cancer, we found that binding of ATP or its nonhydrolyzable analogue AMP-PNP, but not ADP, stabilized the structure of both B-Raf(WT) and B-Raf(V600E). The ATP-competitive type I B-Raf inhibitor vemurafenib and the type II inhibitor sorafenib stabilized the kinase domain (KD) but had distinct effects on the Ras-binding domain. Stabilization of the B-Raf(WT) KD was confirmed by hydrogen/deuterium exchange MS and molecular dynamics simulations. Our results are further supported by cellular assays in which we assessed cell viability and phosphorylation profiles in cells expressing B-Raf(WT) or B-Raf(V600E) in response to vemurafenib or sorafenib. Our data indicate that an overall stabilization of the B-Raf structure by specific inhibitors activates MAPK signaling and increases cell survival, helping to explain clinical treatment failure. We also applied our method to monitor conformational changes upon nucleotide binding of the pseudokinase KSR1, which holds high potential for inhibition in human diseases.
Analysis of the heterogeneity of the biological responses to native and mutant human interleukin-6 (1992)

The structure-function relationships of the biological activities of mutant varieties of the pleiotropic cytokine interleukin-6 (human) were measured by three assays: induction of immunoglobulin M (IgM) secretion from an Epstein-Barr virus-transformed human B cell line and induction of fibrinogen secretion from either a human hepatoma cell line or a rat hepatoma cell line. The biological effects of the cytokine were characterized by three parameters as determined by a novel analysis: effectiveness (the maximal response attainable), efficiency (the concentration yielding a half-maximal response), and complexity (a measure of heterogeneity and feedback control). Substitution of serine for cysteine was associated with a reduction in the effectiveness of interleukin-6 in both fibrinogen secretion assays. In the assay with human hepatoma cells, there was also a profound reduction in efficiency. Serine substitution in the human IgM synthesis assay appears mainly to reduce the efficiency. Deletion of amino acids 4 to 23 increased the efficiency in the rat hepatoma assay. The complexity parameter suggests the presence of multiple receptor classes or negative feedback in all three assays. Use of the proposed sequential approach to the analysis of dose-response relations in bioassays provides a more useful quantitative assessment of activities as well as more insight into the complexity of the reactions.
Computer-Based Simulation and Scaled Laboratory Bench System for the Teaching and Training of Engineers on the Control of Doubly Fed Induction Wind Generators (2010)

Among the existing renewable sources, wind energy is reaching production rates that are becoming important on the worldwide energy scene. Since the control of these wind generators is a very technical discipline, practical teaching methodologies are of special relevance. Paradoxically, in the past, the training of engineers specializing in this area has lacked the practical component represented by field tests, due to the difficulty of access to this kind of installation. This paper presents a system designed for use both in teaching and training procedures for control strategies for wind generators with doubly fed induction generator (DFIG) technology. The system includes two phases or levels of use: the first being a simulation phase based on computer models, and the second, an advanced level which allows for the conducting of tests on a laboratory scaled workbench composed of a wind turbine emulator coupled to an electric generator. With this equipment, the effectiveness of the wind generator regulation systems can be analyzed from the point of view of the maximum power point tracking control strategy, as well as from that of the contribution produced by the wind generator to the control of the operation of the electric grid to which it is connected.
Synthesis, Characterization, and Crystal Structures of Iron(II) and Manganese(II) Complexes with 4,7-bis(2-pyridylmethyl)-1-thia-4,7-diazacyclononane (1998)

A new synthesis has been developed for 1-thia-4,7-diazacyclononane and the complexation behavior of a particular derivative has been explored. The pentadentate ligand 4,7-bis(2-pyridylmethyl)-l-thia-4,7-diazacyclononane ([9]) and its iron(Ⅱ) and manganese(Ⅱ) complexes were prepared and characterized. Magnetic moments of 5.17 and 5.90 μB respectively, indicate that the iron(Ⅱ) and manganese(Ⅱ) complexes are high spin. Charge transfer transitions (d-π*) occur for [Fe(Ⅱ)([9]at 27027, 25000, and 24390 cm-1 for X=, Cl-, and OH-, respectively. In acetonitrile solution, the cyclic voltammogram of the manganese(Ⅱ) complex exhibits a redox couple at 0.92 V vs. NHE while the redox potentials for [Fe(Il)([9] are 0.70, 0.66, and 0.37 V vs. NHE for X=, Cl-, and OH-, respectively. The d-π* charge transfer energy and Fe(Ⅱ)/Fe(Ⅲ) redox potential for [Fe(Ⅱ)([9] increase in the same order: $H_2O>Cl^- >OH^-$. The crystal structures of the iron(Ⅱ) and manganese(Ⅱ) complexes reveal that the metal ions are sixcoordinate, binding to four nitrogen atoms and a sulfur atom from the pentadentate ligand, as well as a chloride anion, with the chloride and sulfur atoms in cis positions. The two metals have similar coordination geometries, which are closer to trigonal prismatic than octahedral. In both iron and manganese complexes, the M-N() trans to Cl- is 0.07 Å longer than the one cis to Cl- , and M-N() trans to S is 0.05 longer than the one cis to S atom.
Whole-Genome Analysis of Sporadic Amyotrophic Lateral Sclerosis (2007)

Variants of FLJ10986 may confer susceptibility to sporadic ALS. FLJ10986 and 50 other candidate loci warrant further investigation for their potential role in conferring susceptibility to the disease.
Advanced Repeater Architectures with Ultra-Long Spans for Submarine Systems (2008)

We present a comparative analysis of two remotely pumped amplifiers schemes used for long-haul transmission. Our numerical and experimental studies show that the remotely pumped EDFA scheme is superior to the Raman assisted EDFA system.
New low-pressure synthesis of phosphine-containing cobalt carbonyl complexes: Co2(CO)6(PR3)2 (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew low-pressure synthesis of phosphine-containing cobalt carbonyl complexes: Co2(CO)6(PR3)2Rocco A. PacielloCite this: Organometallics 1993, 12, 2, 565–567Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/om00026a045https://doi.org/10.1021/om00026a045research-articleACS PublicationsRequest reuse permissionsArticle Views124Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A pixel structure for simultaneous programming and emission method for shutter‐glasses‐type stereoscopic 3‐D AMOLED displays (2012)

Abstract— A pixel structure for shutter‐glasses‐type stereoscopic 3‐D active‐matrix organic light‐emitting‐diode (AMOLED) displays is proposed. The proposed pixel programs data to the pixel during the light‐emission time of an OLED. Because the emission time of the proposed pixel is extended, it is expected that the proposed pixel not only decreases the peak current of the OLED during the emission period but also reduces flicker. Moreover, the aperture ratio of the proposed pixel is 58.69% for a 50‐in. full‐high‐definition (FHD) condition by minimizing the number of thin‐film transistors (TFTs), capacitors, and control signal lines as seven TFTs, two capacitors, two power lines, and four control lines per unit pixel. Simulation results show that the error in the emission current of the proposed pixel is from −0.82% to +0.90% when the threshold‐voltage variation of the driving TFT is ±1.00 V, and the maximum variation of the emission current is −1.35% when a voltage drop in the power line is −0.50 V on a full‐white‐image display.
Interpretable Graph-Based Semi-Supervised Learning via Flows (2017)

In this paper, we consider the interpretability of the foundational Laplacian-based semi-supervised learning approaches on graphs. We introduce a novel flow-based learning framework that subsumes the foundational approaches and additionally provides a detailed, transparent, and easily understood expression of the learning process in terms of graph flows. As a result, one can visualize and interactively explore the precise subgraph along which the information from labeled nodes flows to an unlabeled node of interest. Surprisingly, the proposed framework avoids trading accuracy for interpretability, but in fact leads to improved prediction accuracy, which is supported both by theoretical considerations and empirical results. The flow-based framework guarantees the maximum principle by construction and can handle directed graphs in an out-of-the-box manner.
Story‐focused reading in online news and its potential for user engagement (2016)

We study the news reading behavior of several hundred thousand users on 65 highly visited news sites. We focus on a specific phenomenon: users reading several articles related to a particular news development, which we call story‐focused reading . Our goal is to understand the effect of story‐focused reading on user engagement and how news sites can support this phenomenon. We found that most users focus on stories that interest them and that even casual news readers engage in story‐focused reading. During story‐focused reading, users spend more time reading and a larger number of news sites are involved. In addition, readers employ different strategies to find articles related to a story. We also analyze how news sites promote story‐focused reading by looking at how they link their articles to related content published by them, or by other sources. The results show that providing links to related content leads to a higher engagement of the users, and that this is the case even for links to external sites. We also show that the performance of links can be affected by their type, their position, and how many of them are present within an article.
A prescaler circuit for a superconductive time-to-digital converter (2001)

The high-speed capability of superconductive electronics is being harnessed to develop a time-to-digital converter (TDC) with picosecond time resolution. We have designed and successfully tested prescaler circuits for improving TDC resolution first to 5 ps, and then below. These circuits are designed to act as a vernier for a superconductive TDC that counts clock periods using a binary counter. One prescaler circuit has already demonstrated 5 ps resolution at a clock frequency of 20 GHz.
LTCC Broadside Coupler Design with Branch Lines for Enhanced Performances (2007)

This paper proposes a compensation technique to enhance return loss and directivity of a broadside coupler by using additional branch lines. The use of branch lines at all ports results in improvement of impedance matching for the tight coupled broadside coupler. The equal-division broadside couplers with and without compensation have been designed and fabricated by employing low temperature co-fired ceramic (LTCC) process. The measured results of the proposed coupler exhibit more than 8.0 dB improvement of return loss and isolation compared with those of the conventional one at the center frequency of 3.5 GHz. The measured results show good agreement with the simulated ones, considering the fabricated shrinkage error of LTCC process.
Investigating the Calculation of Rotational Viscosity of the Mixture Comprising Different Kinds of Liquid Crystals: Molecular Dynamics Computer Simulation Approach (2011)

Abstract Molecular dynamics (MD) computer simulation techniques, as a powerful tool commonly utilized by the liquid crystal display (LCD) community, usually are employed for computing the equilibrium and transport properties of a classical many body system, since they are very similar to real experiments in many respects. In this paper we present molecular dynamics computer simulation results taken for a mixture of the two different kinds of nematic liquid crystals (LCs). We calculated rotational viscosity from Brownian behavior with friction of the mean director of the mixture comprising pentylcyanobiphenol (5CB) and decylcyanobiphenol (10CB) by using molecular dynamics computer simulation, where intermolecular potential parameter is Generalized AMBER force field (GAFF). Our computed results show a good agreement with the experimental results.
Cutting Edge: Anti-Inflammatory Properties of Low Levels of IFN-γ (2002)

Activation of naive T and B cells occurs only within the context of organized lymphoid tissue. Thus, the continuous recirculation of mature lymphocytes is crucial for the development of primary immune response to foreign Ags. We have previously shown that low levels of IFN-gamma inhibit homing of B cells to the secondary lymphoid organs. In this study, we demonstrate that similarly low doses of IFN-gamma down-regulate integrin-mediated adhesion and migration of naive T and Th2 cells, and have a profound effect on the in vivo homing of naive T cells to the lymph nodes. Moreover, we show that these low doses of IFN-gamma have anti-inflammatory effects in an in vivo asthma model. Thus, in contrast to the proinflammatory effects of IFN-gamma at relatively high concentrations, low dose IFN-gamma appears to exert global suppressory effects on T cell trafficking and may have clinical application as an anti-inflammatory agent.
ChemInform Abstract: SYNTHESIS, CHEMISTRY AND STEREOCHEMISTRY OF PHOSPHORORGANIC THIOCYANATES P(X)SCN AND ISOTHIOCYANATES P(X)NCS, REARRANGEMENT OF THIO‐ INTO ISOTHIOCYANATES (1977)

Abstract Ziel und Ergebnis der Untersuchung ist die Synthese der relativ unbeständigen phosphor‐ organischen Thiocyanate vom Typ (IIa) und (IIb) und deren Umlagerung in die thermodynamisch stabileren Isothiocyanate (IIIa) und (IIIb).