gebhart/patrepeval huggingface dataset:
Tunable decoupling of tri-band LTE700/GSM850/900 MIMO antenna with a parasitic scatterer for handheld devices (2015)

This paper presents a simple tunable decoupling mechanism for a tri-band coupled monopole antenna working in LTE700/GSM850/900 bands for MIMO application. A parasitic scatterer with two distributed MEMS tunable capacitors is utilized to match the impedance and mitigate the effects of mutual coupling between elements. Thus, the antenna performance is enhanced significantly by minimizing the coupling current. The prototype is evaluated through the scattering parameters, the total efficiency, the envelope correlation coefficient, radiation patterns, current distributions and fully characterized through simulations. By utilizing a simple passive de-coupling structure, the total efficiency is improved with 1–1.5 dB and a reduction in the envelope correlation coefficient in the order of 60–75% is obtained over a wide aggregated bandwidth. Due to the change in radiation mechanism for both of the antennas, orthogonal radiation patterns are formed. With this approach, the design of the mobile phone antenna can be simplified by moving to complexity from the antenna to the decoupling structure.
Experiments on the directional startle reflex in goldfish. (1996)

The acoustic startle reflex in goldfish (Carassius auratus) was studied experimentally in the large acoustic tank at Georgia Tech. Individual free swimming fish were placed in an acoustically transparent cage and positioned in the center of the tank. Their behavior was graded for a response to acoustic signals and the direction of response with respect to the sound source. A preliminary study indicated two interesting features. First, the fish was much more likely to respond in the ‘‘correct’’ direction (away from the source) when responding to subthreshold stimuli. Second, there was strong dependence of signal amplitude at threshold on fish size. For the two weight groups tested (1.6 g, n=3 and 23.6 g, n=4), the sound-pressure level at threshold was 15 dB lower for the smaller subjects. The initial study has recently been augmented with tests on a range of subjects weighing between these two extremes. Also, since only the first half-cycle of the acoustic stimulus is thought necessary to elicit the response, the concept of frequency to characterize the sound stimulus is inappropriate. Therefore, thresholds were measured as a function of signal rise time. A parallel effort has involved modeling a biologically relevant stimulus: the acoustic field generated by an attacking predator. [Work supported by ONR.]
The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes (2021)

Wilms tumor (WT) is the most common renal tumor in childhood. We and others have previously identified oncogenic driver mutations affecting the microprocessor genes DROSHA and DGCR8 that lead to altered miRNA expression patterns. In the case of DGCR8, a single recurrent hotspot mutation (E518K) was found in the RNA binding domain. To functionally assess this mutation in vitro, we generated mouse Dgcr8-KO embryonic stem cell (mESC) lines with an inducible expression of wild-type or mutant DGCR8, mirroring the hemizygous mutant expression seen in WT. RNA-seq analysis revealed significant differences of miRNA expression profiles in DGCR8-E518K compared with DGCR8-wild-type mESCs. The E518K mutation only led to a partial rescue of the reported miRNA processing defect in Dgcr8-KO, with selectively reduced expression of numerous canonical miRNAs. Nevertheless, DGCR8-E518K retained significant activity given its ability to still process many miRNAs. Subsequent to altered miRNA levels, the expression of mRNA targets was likewise changed. Functional assays showed that DGCR8-E518K cells still have a partial proliferation and differentiation defect but were able to rescue critical biological processes in embryoid body development. The stem cell program could be shut down and all three germ layers were formed. These findings suggest that the E518K mutation leads to a partial reduction of microprocessor activity and altered specificity with selective impairment only in certain developmental contexts, apparently including nephrogenesis.
Smart mask ship to control for enhanced on wafer CD performance (2016)

In the process of semicondutcor fabrication the translation of the final product requirements into specific targets for each component of the manufacturing process is one of the most demanding tasks. This involves the careful assessment of the error budgets of each component as well as the sensible balancing of the costs implied by the requirements. Photolithographic masks play a pivotal role in the semiconductor fabrication. This attributes a crucial role to mask error budgeting within the overall wafer production process. Masks with borderline performance with respect to the wafer fabrication requirements have a detrimental effect on the wafer process window thus inducing delays and costs. However, prohibitively strict mask specifications will induce large costs and delays in the mask manufacturing process. Thus setting smart control mechanisms for mask quality assessment is highly relevant for an efficient production flow. To this end GLOBALFOUNDRIES and the AMTC have set up a new mask specification check to enable a smart ship to control process for mask manufacturing. Within this process the mask CD distribution is checked as to whether it is commensurable with the advanced dose control capabilities of the stepper in the wafer factory. If this is the case, masks with borderline CD performance will be usable within the manufacturing process as the signatures can be compensated. In this paper we give a detailed explanation of the smart ship control approach with its implications for mask quality.
Agranulocytosis During Treatment With Sulfamethoxazole–Trimethoprim and a Proton Pump Inhibitor (2019)

Funakoshi, Haruki BS; Momo, Kenji PhD; Uchikura, Takeshi PhD; Ariizumi, Hirotsugu MD, PhD; Hamada, Kazuyuki MD, PhD; Tsunoda, Takuya MD, PhD; Sasaki, Tadanori PhD Author Information
Neural Network-based OFDM Receiver for Resource Constrained IoT Devices (2022)

Orthogonal Frequency Division Multiplexing (OFDM)-based waveforms are used for communication links in many current and emerging Internet of Things (IoT) applications, including the latest WiFi standards. For such OFDM-based transceivers, many core physical layer functions related to channel estimation, demapping, and decoding are implemented for specific choices of channel types and modulation schemes, among others. To decouple hard-wired choices from the receiver chain and thereby enhance the flexibility of IoT deployment in many novel scenarios without changing the underlying hardware, we explore a novel, modular Machine Learning (ML)-based receiver chain design. Here, ML blocks replace the individual processing blocks of an OFDM receiver, and we specifically describe this swapping for the legacy channel estimation, symbol demapping, and decoding blocks with Neural Networks (NNs). A unique aspect of this modular design is providing flexible allocation of processing functions to the legacy or ML blocks, allowing them to interchangeably coexist. Furthermore, we study the implementation cost-benefits of the proposed NNs in resource-constrained IoT devices through pruning and quantization, as well as emulation of these compressed NNs within Field Programmable Gate Arrays (FPGAs). Our evaluations demonstrate that the proposed modular NN-based receiver improves bit error rate of the traditional non-ML receiver by averagely 61% and 10% for the simulated and over-the-air datasets, respectively. We further show complexity-performance tradeoffs by presenting computational complexity comparisons between the traditional algorithms and the proposed compressed NNs.
Graphene Transistors: Silicon CMOS-Compatible Processing for Applications in Nanoelectronics (2016)

© 2016 by Taylor & Francis Group, LLC. Electrochemical capacitors have been developing fast in recent years, and are slowly becoming an increasingly impor tant component in the energy storage mix. Their particular properties, high power density, and medium energy densities, have made them suitable for a growing number of applications such as regenerative breaking and fast charging toys. Owing to its polarizability, electrical conductivity, acces sibility, easy processability, relatively low cost, and chemical stability in a wide range of pH, traditionally, carbon has been the principal component of electrochemical capacitor elec trodes. There are already well-established methods of obtain ing high surface area materials with controlled pore size. Now graphene, with very high surface area and electrical conduc tivity seems a natural candidate material from which to make supercapacitor electrodes. This chapter reviews efforts toward the application of gra phene in its various forms (from exfoliated powder to vertically chemical vapor-grown carbon nanowalls) into supercapacitor electrodes. Starting from a general introduction into the work ing and mechanism of capacitors and the context in which they operate, we review methods of electrode production, cur rent performance, and possible application areas. We end by suggesting routes for further exploration.
Development of a High Temperature Microbial Fermentation Processfor Butanol Production (2016)

Transforming renewable biomass into cost competitive high-performance biofuels and bioproducts is key to US energy security. Butanol production by microbial fermentation and chemical conversion to polyolefins, elastomers, drop-in jet or diesel fuel, and other chemicals is a promising solution. A high temperature fermentation process can facilitate butanol recovery up to 40%, by using gas stripping. Other benefits of fermentation at high temperatures are optimal hydrolysis rates in the saccharification of biomass which leads to maximized butanol production, decrease in energy costs associated with reactor cooling and capital cost associated with reactor design, and a decrease in contamination and cost for maintaining a sterile environment. Butanol stripping at elevated temperatures gives higher butanol production through constant removal and continuous fermentation. We describe methods used in an attempt to genetically prepare Geobacillus caldoxylosiliticus for insertion of a butanol pathway. Methods used were electroporation of electrocompetent cells, ternary conjugation with E. coli, and protoplast fusion.
GEM-IL: A highly responsive fluorescent lactate indicator (2021)

Lactate metabolism has been shown to have increasingly important implications in cellular functions as well as in the development and pathophysiology of disease. The various roles as a signaling molecule and metabolite have led to interest in establishing a new method to detect lactate changes in live cells. Here we report our development of a genetically encoded metabolic indicator specifically for probing lactate (GEM-IL) based on superfolder fluorescent proteins and mutagenesis. With improvements in its design, specificity, and sensitivity, GEM-IL allows new applications compared with the previous lactate indicators, Laconic and Green Lindoblum. We demonstrate the functionality of GEM-IL to detect differences in lactate changes in human oncogenic neural progenitor cells and mouse primary ventricular myocytes. The development and application of GEM-IL show promise for enhancing our understanding of lactate dynamics and roles.
Regulation of protein synthesis in Tetrahymena. RNA sequence sets of growing and starved cells. (1983)

The complexity of messenger RNA in growing or starved Tetrahymena thermophila is similar and unusually high (approximately 4.5 X 10(7) nucleotides). The complexity of nuclear RNA in growing cells (approximately 7.8 X 10(7) nucleotides) is only about 1.7 times that of mRNA. The concentration of complex class (rare) messages (approximately 53 copies/growing cell and approximately 11 copies/starved cell) is low in comparison to the size of the cell. The concentration of complex nuclear transcripts is also very low (approximately 0.7 copies/growing cell nucleus and approximately 2.6 copies/starved cell nucleus) considering that the macronucleus contains 45 to 90 copies of each single copy sequence. The complex sequence sets found on polysomes of growing and starved cells overlap about 80% and about 60% of the complex nuclear transcripts appear to be held in common. About 60% of macronuclear single copy DNA is transcribed in one or both physiological states. Although growing and starved cells have extremely different fractions of their messages loaded onto polysomes, within each cell type the complex messages in polysomal and nonpolysomal cytoplasmic fractions are indistinguishable, suggesting that exchange may occur between loaded and unloaded messages. Although T. thermophila DNA has an unusually low G + C content (23%), sequences coding for complex RNAs have base ratios similar to those of total DNA. Therefore, codon usage in Tetrahymena must be extremely biased towards adenine- and uridine-rich codons.
Expression of Contactin 4 Is Associated With Malignant Behavior in Pheochromocytomas and Paragangliomas (2017)

CNTN4 expression is consistently associated with malignant behavior in PPGLs.
Comparison of DIC Methods of Determining Forming Limit Strains (2016)

Digital image correlation (DIC) techniques have been used in forming limit tests to obtain forming limit strains and many different methods have been proposed to determine the onset of localized necking in order to improve the accuracy of forming limit curves in recent ten years. Necking limit strains of four sheet materials, including two high strength steels (MP980 and DP600) and one Al alloys (AA6022-T4), were determined by the existing DIC methods in the literature. Through comparison, it is found that both spatial and temporal aspects of localized necking need to be considered to robustly and accurately catch the subtle moment, the onset of localized necking, namely, to accurately determine forming limit strains associated with the onset of localized necking.
IBM Content Manager Tage für Universitäten und Bibliotheken 2004: Content Manager Version 8 Overview (2004)

Beyond production imaging or document management Enable Enterprise Content Management A physical data model describing the "building blocks" Abstractions for modelling content, relationships Add high-level APIs as needed To support different application models and standards Direct mapping to the physical data model Push function down the stack, including into DB2, as required for performance, data integrity, or to leverage strength of other technologies Focus on performance End user response time Scalability
Which therapeutic option for hepatitis C virus genotype 1? (2014)

Sofosbuvir and simeprevir greatly improve the virological response rate compared to first-generation protease inhibitors. All of these data may help in guiding the physician's treatment decisions, based on financial constraints and patient characteristics. These data can be easily updated with future treatment and demonstrate the contribution of new treatment regimens to achieve optimal SVR rates.
Oxidation-Triggered Release of Fluorescent Molecules or Drugs from Mesoporous Si Microparticles (2008)

The fluorescent dye Alexa Fluor 488 or the anticancer drug doxorubicin is attached to the surface and inner pore walls of mesoporous Si particles by covalent attachment, and the oxidation-induced release of each molecule is studied. The molecules are bound to the Si matrix using a 10-undecenoic acid linker, which is attached by thermal hydrosilylation. Loading capacity of the microparticles using this method is approximately 0.5 and 45 mg/g of porous Si microparticle for Alexa Fluor 488 and doxorubicin, respectively. The Si-C-bound assembly is initially stable in aqueous solution, although oxidation of the underlying Si matrix results in conversion to silicon oxide and slow release of the linker-molecule complex by hydrolysis of the Si-O attachment points. When the attached molecule is a fluorophore (Alexa Fluor 488 or doxorubicin), its fluorescence is effectively quenched by the semiconducting silicon matrix. As the particle oxidizes in water, the fluorescence intensity of the attached dye increases due to growth of the insulating silicon oxide layer and, ultimately, dye release from the surface. The recovery of fluorescence in the microparticle and the release of the molecule into solution are monitored in real-time by fluorescence microscopy. Both processes are accelerated by introduction of the oxidizing species peroxynitrite to the aqueous solution. The oxidation-triggered release of the anticancer drug doxorubicin to HeLa cells is demonstrated.
Asymptomatic Employee Screening for SARS-CoV-2: Implementation of and Reactions to an Employer-Based Testing Program (2020)

ABSTRACT Introduction Asymptomatic testing for SARS-CoV-2 among healthcare workers or other essential personnel could remove infected carriers from the workforce, decreasing chances for transmission and workplace outbreaks. Results from one-time testing programs have been reported but data regarding longitudinal testing, including information about employee’s reactions to such programs, is not readily available. Methods To identify asymptomatic carriers of SARS-CoV-2, we implemented a longitudinal screening program for critical on-site employees within our research institute in early April 2020. We conducted a survey of both on-site employees and those working from home in order to measure their reactions to the testing program. Statistical analysis of the survey was conducted with general linear regression and Pearson’s Chi-Square tests. Results Despite an ongoing high community prevalence rate of COVID-19, to date only two asymptomatic employees tested positive out of 1050 tests run during 7 months of the program. However, 12 symptomatic employees not participating in the program have tested positive. The employee survey was completed by 132/306 (43%) employees, with 93% agreeing that asymptomatic employee screening led to a better and safer working environment and 75% agreeing with on-site public health measures to help contain the virus, but only 58% feeling COVID-19 was a serious threat to their health. Conclusion Our results suggest that a longitudinal asymptomatic employee screening program for SARS-CoV-2 can be accepted by employees and can be used to maintain the health of the workforce, potentially keeping positivity rates below community levels in the face of the ongoing COVID-19 pandemic.
Controlled surface‐initiated ring‐opening polymerization of L‐lactide from risedronate‐anchored hydroxyapatite nanocrystals: Novel synthesis of biodegradable hydroxyapatite/poly(L‐lactide) nanocomposites (2011)

Abstract Risedronate‐anchored hydroxyapatite (HA‐RIS) nanocrystals were prepared with 4.1 wt % RIS and used for controlled surface‐initiated ring‐opening polymerization (ROP) of L ‐lactide ( L ‐LA). The strong adsorption of RIS to HA surface not only led to enhanced dispersion of HA nanocrystals in water as well as in organic solvents but also provided alkanol groups as active initiating species for ROP of L ‐LA. HA‐RIS was characterized by thermogravimetric analysis, dynamic light scattering, 1 H NMR, Fourier transform infrared spectrometer, and X‐ray diffraction. The graft polymerization of L ‐LA onto HA‐RIS took place smoothly in the presence of stannous octoate in toluene at 120 °C, resulting in HA/poly( L ‐LA) nanocomposites with high yields of 85–90% and high poly( L ‐LA) contents of up to 97.5 wt %. Notably, differential scanning calorimetry measurements revealed that the poly( L ‐LA) in HA/poly( L ‐LA) nanocomposites exhibited considerably higher melting temperatures ( T m = 173.3−178.1 °C) and higher degrees of crystallinity ( X c = 41.0−43.1%) as compared to poly( L ‐LA) homopolymer ( T m = 168.5 °C, X c =25.7%). In addition, our initial results showed that these HA/poly( L ‐LA) nanocomposites could readily be electrospun into porous matrices. This study presented a novel and controlled synthetic strategy to HA/RIS/poly( L ‐LA) nanocomposites that are promising for orthopedic applications as well as for bone tissue engineering. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
Integrated genomics and avatar mouse models for personalized cancer treatment. (2013)

2511 Background: Every cancer has its unique set of molecular changes and the knowledge of such alterations is enabling an individualized approach to cancer treatment. The great intellectual challenge lies in linking confirmed mutations to protein function. Methods: Using massive parallel sequencing we performed whole exome sequencing analysis of 30 patients (pts) with advanced solid tumors to identify putatively actionable tumor-specific genomic alterations. We used 2 in silico methods (Polyphen and SIFT) to estimate the functional significance of a given confirmed mutation. Avatar models generated by direct engraftment of tumor samples from the patients into immunocompromised mice were used as an in vivo platform to test proposed treatment strategies. Results: Successful exome sequencing analyses has been obtained for 28 pts. Tumor specific mutations (Muts) and copy number variations were identified ranging from 5 to 952 and 0 to 956 respectively. All samples profiled contained relevant genomic alterations. Some of the most relevant actionable alterations were: CHEK1, FGFR2, IGF1R, MET, BRCA1, XPC, NOTCH, CREB3LB, GNA11, SMAD4, NF1, PTPRC, PI3KA, DDR2 and EGFR. An Avatar model was generated for 15 patients. In occasions actionable alterations such as muts in NF1, PTPRC, PI3KA and DDR2 failed to provide any benefit when a targeted drug was tested in the Avatar and accordingly treatment of the pts with these drugs was not effective. So far 13 pts have received a personalized treatment: two, as expected based on the avatar model, did not response; 5 resulted in durable partial remissions. Eight pts are currently on treatment with at least disease stabilization. Bench testing of candidate treatments in Avatar models correlated with clinical response and helped to select empirical treatments in patients with no actionable mutations. Conclusions: The use of full genomic analysis for cancer care is promising but presents important challenges that will need to be solved for broad clinical application. Avatar models are a powerful investigational platform for therapeutic decision making and help to guide cancer treatment in the clinic. While limitations still exist, this strategy should be tested in prospective randomized clinical trials.
Inclusion orientation dependent flaking process in rolling contact fatigue observed by laminography using ultrabright synchrotron radiation X‐ray (2022)

Abstract The formation and propagation of cracks in rolling contact fatigue were observed by synchrotron radiation computed laminography, and the effect of stringer‐type inclusion orientation was examined. For longitudinal inclusions, cracks started forming at their tips. After cracks propagated toward the rolling direction, a longitudinal crack was kinked simultaneously at both its tips, and propagated toward the direction perpendicular to the rolling direction to form lateral cracks. After kinking, horizontal cracks were formed from the deepest point of a lateral crack, leading to flaking. On the other hand, for specimens with lateral inclusions, cracks propagated to the lateral direction without the formation of longitudinal cracks. Since the propagation life of lateral cracks and that of horizontal cracks were unrelated to the inclusion orientation, the rolling contact fatigue life of specimens with longitudinal inclusions was considerably longer than that of specimens with lateral inclusions.