gebhart/patrepeval huggingface dataset:
Clinical application of the serum 1,5‐anhydroglucitol assay method using glucose 3‐dehydrogenase (2002)

We attempted to develop a novel serum 1,5-anhydroglucitol (1,5-AG) assay kit using glucose 3-dehydrogenase (G3DH) from Halomonas sp. alpha-15 strain. The major advantages of this method are that the 1,5-AG detection requires a very small amount of G3DH, and the enzyme catalyzes a simple reaction. The analytical performances were acceptable for clinical use operated with a clinical automatic analyzer. The correlation with a commercial assay kit against sera of healthy volunteers was y=0.975x+0.008, r=0.993, Sylx=1.32 microg/mL. However, sham-negative specimens were observed in the validation of this method using specimens from hospital patients.
Research of overall control system for PMSM Based on Digital Signal Processor (2013)

With the rapid development of permanent magnet materials, power electronics and control theory, based on vector control of PMSM its excellent control performance, high power density and high efficiency, more and more used in a variety of high-performance servo systems and other fields of industrial production[1-2]. In recent years, the development of vector control theory and methods become mature gradually, the progress of integrated circuits and computer technology, the PMSM vector control system has been a great development. The vector control of PMSM based on the mathematical model in the dq coordinate system, through conversion of vector model, realize that it has completely decoupled control of stator current. It has like a DC motor control performance, and thus more widely applied[3]. This paper introduces the mathematical model of PMSM in the dq coordinate system, modeling and analysis of PMSM vector control strategies based on the 0 d i  , for DSP TMS320F2812 as controller core, built a power-driven circuit, control circuit, feedback circuit and the main auxiliary circuit. The algorithm of control program was completed based the hardware platform, and presented its software processes. Constitute a high-performance PMSM vector control system, and through experimental results demonstrate the superiority of the system.
"President Vows to Cut Hair": Dataset and Analysis of Creative Text Editing for Humorous Headlines (2019)

We introduce, release, and analyze a new dataset, called Humicroedit, for research in computational humor. Our publicly available data consists of regular English news headlines paired with versions of the same headlines that contain simple replacement edits designed to make them funny. We carefully curated crowdsourced editors to create funny headlines and judges to score a to a total of 15,095 edited headlines, with five judges per headline. The simple edits, usually just a single word replacement, mean we can apply straightforward analysis techniques to determine what makes our edited headlines humorous. We show how the data support classic theories of humor, such as incongruity, superiority, and setup/punchline. Finally, we develop baseline classifiers that can predict whether or not an edited headline is funny, which is a first step toward automatically generating humorous headlines as an approach to creating topical humor.
Case Report: New CDKN1B Mutation in Multiple Endocrine Neoplasia Type 4 and Brief Literature Review on Clinical Management (2022)

According to the cases reported in the literature, hyperparathyroidism is the most common clinical feature of MEN4, followed by pituitary adenoma and neuroendocrine tumors. However, MEN4 appears to be a variant of MEN with milder clinical features and later onset. Therefore, these patients might need a different and personalized approach in clinical management and a peculiar screening and follow-up strategy.
No Time to Waste, with SWAM! (2019)

Managing waste from professional customers (e.g. restaurants, shops) has an impressive number of requirements that must be met to ensure a high quality of service and environmental compliance. Existing decision support systems generally rely on a limited flow of information and offer an often static or statistically based approach. With SWAM, we aim to create a smart waste collection system relying on data generated by new fill-level sensor technologies integrated into waste bins. Through this demonstration, we intend to show how artificial intelligence and new sensing technologies can be of benefit to this sector. The project concept will be showcased through a small-scale interactive demonstration where the audience will be responsible for the proper execution of the waste collection processes. A video of the demo is available online1 -It shows the interaction between the audience, our decision-making systems, waste collection robot and miniature bins equipped with ultrasonic sensors.
A 3.5 ns/77 K and 6.2 ns/300 K 64 K CMOS RAM with ECL interfaces (1989)

A 64 K CMOS RAM with emitter-coupled logic (ECL) interfaces having access times of 6.2 ns at room temperature and with a CMOS process specifically optimized for low-temperature operation, 3.5 ns at liquid nitrogen (LN) temperature, is presented. The CMOS processes feature a 0.5 mu m L/sub eff/, self-aligned TiSi/sub 2/ double-level metal, and an average minimum feature size of 1.35 mu m. Circuits keyed to high-speed operation are described with emphasis on low power and safe operation. Unique aspects of LN-temperature operation including circuit-device interactions, the impact of velocity saturation effects on channel length, temperature and power supply sensitivities, and the characteristics of the ECL-to-CMOS receiver circuits are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Structure ofD-lactate dehydrogenase fromAquifex aeolicuscomplexed with NAD+and lactic acid (or pyruvate) (2009)

The crystal structure of D-lactate dehydrogenase from Aquifex aeolicus (aq_727) was determined to 2.12 A resolution in space group P2(1)2(1)2(1), with unit-cell parameters a = 90.94, b = 94.43, c = 188.85 A. The structure was solved by molecular replacement using the coenzyme-binding domain of Lactobacillus helveticus D-lactate dehydrogenase and contained two homodimers in the asymmetric unit. Each subunit of the homodimer was found to be in a ;closed' conformation with the NADH cofactor bound to the coenzyme-binding domain and with a lactate (or pyruvate) molecule bound at the interdomain active-site cleft.
Capturing Secured Application Traffic for Analysis (2022)

Following the famous adage that goes “Necessity is the mother of any invention,” securing end-to-end traffic is an evolution happening for the past couple of decades in an attempt to secure the user and data privacy from malicious hackers.
Automatic Feeding system for Aquaculture (2017)

Automatic Feeding system for Aquaculture is an innovative product in which aqua farmer can feed the aquatic creatures in their fisheries and different fishing habitats. The system contains mainly a boat which has an in built container where the fish feed is loaded. The automatic controlled boat can to feed both solid and liquid feed as well medicines. The farmer can just sit on the banks of the pond and operate the boat using an RF transmitter. The navigation of the boat will be easier and less complicated due to the video transmitter and receiver fixed to the boat.
Dynamic modeling of viral infections in spherical organs (2011)

A general mathematical model of viral infections inside a spherical organ is presented. Transported quantities are used to represent external cells or viral particles that penetrate the organ surface to either promote or combat the infection. A diffusion mechanism is considered for the migration of transported quantities to the inner tissue of the organ. Cases that include the generation of latent infected cells and the delivery of anti-viral treatment are analyzed. Different anti-viral mechanisms are modeled in the context of spatial variation. Equilibrium conditions are also calculated to determine the radial profile after the infection progresses and therapy is delivered for a long period of time. The dynamic and equilibrium solutions obtained in this paper provide insight into the temporal and spatial evolution of viral infection for optimal therapies.
Suppression of multiple pulse formation in external-cavity mode-locked semiconductor lasers using intrawaveguide saturable absorbers (1992)

Imperfect antireflection coatings in external-cavity mode-locked semiconductor lasers can cause multiple output pulse generation. The incorporation of an intrawaveguide saturable absorber segment into the laser suppresses this problem. Single pulse outputs of less than 2.8 ps and 0.7 pJ of energy are obtained using such devices with both quantum well and bulk active regions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Re-constructing high-level information for language-specific binary re-optimization (2016)

In this paper, we show a binary optimizer can achieve competitive performance relative to a state-of-the-art source code compiler by re-constructing high-level information (HLI) from binaries. Recent advances in compiler technologies have resulted in a large performance gap between binaries compiled with old compilers and those compiled with latest ones. This motivated us to develop a binary optimizer for old binaries using a compiler engine for a latest source code compiler. However, a traditional approach to naively convert machine instructions into an intermediate representation (IR) of the compiler engine, does not allow us to take full advantage of optimization techniques available in the compiler. This is because the HLI, such as information about variables and their data types, is not available in such an IR. To address this issue, we have devised a technique to re-construct the HLI from binaries by using contextual information. This contextual information is a set of knowledge about specific compilation technologies, such as the conventions of data structures, the patterns of instruction sequences, and the semantics of runtime routines. With this technique, our binary optimizer has improved the performance of binaries generated from an older compiler by 40.1% on average in the CPU time for a set of benchmarks, which is close to the one due to a source-code recompilation with the same compiler engine, 55.2% on average.
Study on Characteristics of Human Body Shadowing in High Frequency Bands: Radio Wave Propagation Technology for Future Radio Access and Mobile Optical Networks (2014)

To address the rapid increase in the volume of data traffic in mobile communication networks, small cells that enable data transmission at a high bit rate and use very high frequency bands (over 6 GHz) have been studied recently. Considering that the environment into which small cells are introduced is crowded and dominated by line of sight communications with very high data traffic loads, the characteristics of human body shadowing (HBS) are important propagation parameters. In this paper, we propose a method for analyzing HBS characteristics based on the uniform geometrical theory of diffraction and lossy dielectric flat plates. Calculated results are compared to measured results to show that the proposed method is effective in analyzing the HBS characteristics.
In VitroandIn VivoInvestigation of the Potential of Amorphous Microporous Silica as a Protein Delivery Vehicle (2013)

Delivering growth factors (GFs) at bone/implant interface needs to be optimized to achieve faster osseointegration. Amorphous microporous silica (AMS) has a potential to be used as a carrier and delivery platform for GFs. In this work, adsorption (loading) and release (delivery) mechanism of a model protein, bovine serum albumin (BSA), from AMS was investigated in vitro as well as in vivo. In general, strong BSA adsorption to AMS was observed. The interaction was stronger at lower pH owing to favorable electrostatic interaction. In vitro evaluation of BSA release revealed a peculiar release profile, involving a burst release followed by a 6 h period without appreciable BSA release and a further slower release later. Experimental data supporting this observation are discussed. Apart from understanding protein/biomaterial (BSA/AMS) interaction, determination of in vivo protein release is an essential aspect of the evaluation of a protein delivery system. In this regard micropositron emission tomography (μ -PET) was used in an exploratory experiment to determine in vivo BSA release profile from AMS. Results suggest stronger in vivo retention of BSA when adsorbed on AMS. This study highlights the possible use of AMS as a controlled protein delivery platform which may facilitate osseointegration.
ChemInform Abstract: Directed Lithiation in Arenetricarbonylchromium(0) Complexes: Assessment of Some Directing Group Specificities and of Electrophilic Quench Efficacies. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
TOLERANCE INDUCTION IN RATS DOES NOT REQUIRE GRAFT RESIDENT DONOR-TYPE ANTIGEN PRESENTING CELLS (1998)

498 Background: It has been postulated that donor-type bone marrow-derived antigen presenting cells (APCs) may be important for tolerance induction via a mechanism of posttransplant microchimerism. Our goal was to use chimeric hearts created via BMT to test whether donor-type APCs are required for the induction and maintenance of cardiac allograft tolerance in the rat. Methods: Chimeric PVG hearts were created via DA→PVG BMTs. Elimination of PVG APCs was confirmed by flow cytometry, MLR, immunohistochemistry and RT-PCR. Chimeric and naïve hearts were then used for heterotopic transplants, in which APCs were matched or mismatched to the recipient, while organ parenchyma was always mismatched to the recipient. To induce tolerance, oral cyclosporine (CyA, 20 mg/kg, ×10 days) was given following transplantation. Rejection was monitored by palpation of the graft and histological analysis was performed in a blinded fashion. Results: CyA led to permanent survival of PVG→DA heart grafts with minimal vascular changes. 5/7 chimeric PVG hearts survived long-term in untreated DA recipients, but uniformly demonstrated mild cellular rejection and cardiac allograft vasculopathy (CAV). 4/6 chimeric PVG hearts survived long-term in CyA treated recipients, and two of these long-term surviving hearts that have been examined showed focal rejection and moderate CAV. TableAnimals from all experimental groups accepted second naïve PVG hearts(normal histology) without immunosuppression (Group II: 3/3, Group III: 2/2, Group IV: 3/3) and rejected third party F344 hearts (Groups II, IV: 2/2), confirming induction of antigen-specific tolerance in CyA-treated recipients. Conclusions: Donor-type bone marrow-derived APCs are not required for tolerance induction in this rat model. Furthermore, these data support recently published work by Tullius et al showing that donor-specific tolerance can develop despite the presence of vasculopathy in the first graft.
Data from Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Clinical responses with programmed death (PD-1) receptor–directed antibodies occur in about 20% of patients with advanced head and neck squamous cell cancer (HNSCCa). Viral neoantigens, such as the E6/E7 proteins of HPV16/18, are attractive targets for therapeutic immunization and offer an immune activation strategy that may be complementary to PD-1 inhibition.&lt;/p&gt;Patients and Methods:&lt;p&gt;We report phase Ib/II safety, tolerability, and immunogenicity results of immunotherapy with MEDI0457 (DNA immunotherapy targeting HPV16/18 E6/E7 with IL12 encoding plasmids) delivered by electroporation with CELLECTRA constant current device. Twenty-two patients with locally advanced, p16&lt;sup&gt;+&lt;/sup&gt; HNSCCa received MEDI0457.&lt;/p&gt;Results:&lt;p&gt;MEDI0457 was associated with mild injection site reactions, but no treatment-related grade 3–5 adverse events (AE) were noted. Eighteen of 21 evaluable patients showed elevated antigen-specific T-cell activity by IFNγ ELISpot, and persistent cellular responses surpassing 100 spot-forming units (SFUs)/10&lt;sup&gt;6&lt;/sup&gt; peripheral blood mononuclear cells (PBMCs) were noted out to 1 year. Induction of HPV-specific CD8&lt;sup&gt;+&lt;/sup&gt; T cells was observed. MEDI0457 shifted the CD8&lt;sup&gt;+&lt;/sup&gt;/FoxP3&lt;sup&gt;+&lt;/sup&gt; ratio in 4 of 5 post immunotherapy tumor samples and increased the number of perforin&lt;sup&gt;+&lt;/sup&gt; immune infiltrates in all 5 patients. One patient developed metastatic disease and was treated with anti–PD-1 therapy with a rapid and durable complete response. Flow-cytometric analyses revealed induction of HPV16-specific PD-1&lt;sup&gt;+&lt;/sup&gt; CD8&lt;sup&gt;+&lt;/sup&gt; T cells that were not found prior to MEDI0547 (0% vs. 1.8%).&lt;/p&gt;Conclusions:&lt;p&gt;These data demonstrate that MEDI0457 can generate durable HPV16/18 antigen-specific peripheral and tumor immune responses. This approach may be used as a complementary strategy to PD-1/PD-L1 inhibition in HPV-associated HNSCCa to improve therapeutic outcomes.&lt;/p&gt;&lt;/div&gt;
Small-Area Deposition of Light Emission Polymer by Evaporative Spray Deposition from Ultradilute Solution Technique (2005)

The evaporative spray deposition from ultradilute solution (ESDUS) technique has enabled the preparation of organic devices from highly diluted solutions of polymer semiconductors. Here, we report another feature of this technique, the pixel-size deposition of a π-conjugated polymer. Small-area coating was carried out using a simple shadow mask with pixel-size holes. A blue-emission polymer, PFHB, was deposited through the mask. The resultant film had a pixel pattern of 10 µm separation. Moreover, a green-emission polymer, CN-PDHFV, was subsequently deposited over the first patterned layer. The pixel pattern was maintained clear without getting blurred even using the same solvent, tetrahydrofuran, for each polymer deposition. An electroluminescent (EL) device consisting of a patterned partial double layer showed a green emission from a single layer area.
Control of a Merged-Energy-Buffer based Two-Stage Electrolytic-Free Offline LED Driver (2019)

This paper presents the control techniques used in a high-power-density electrolytic-free offline LED driver that utilizes a merged energy buffer for twice-line-frequency energy buffering. This LED driver comprises two stages: a four-switch buck-boost PFC stage and an LLC resonant dc-dc stage. The proposed control technique for the PFC stage utilizes a novel mode splitter to ensure a smooth buck-to-boost and vice versa mode transition. A feedforward control strategy is proposed for the dc-dc stage, which in conjunction with feedback control, ensures a well-regulated output voltage by mitigating undesirable spikes in it. A 150-W prototype LED driver utilizing a merged energy buffer is tested with the proposed control techniques. This GaN-based prototype achieves a high power density of 50 W/inch <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> while replacing electrolytic capacitors with low-energy-density ceramic capacitors.
The Laws of Thermodynamics Tell You What Is and What Is Not Possible (2017)

Avelino Corma, the distinguished research chemist explains why scientific discovery is difficult. He then explains how ‘molecular recognition’ is achieved in nanochemistry, how molecular design and creating nanoreactors with zeolites is carried out in the laboratory to trap nanoparticles and make them react selectively, and what is meant by the ‘sociology of nanoparticles’. The relationship of chemistry with brain function or genome evolution is also considered. He then reflects on the role of chemistry from ancient times, when the discovery and synthesis of ammonia enabled the development of agriculture and societies, to the world as we know it today. The reason why chemistry is a fundamental discipline for balancing our ‘energy basket’ is also discussed, particularly with regard to achieving sustainable development of our planet.
Marketing Locally Produced Organic Foods in Three Metropolitan Arkansas Farmers’ Markets: Consumer Opinions and Food Safety Concerns (2011)

Consumers embrace local food systems as an alternative to the global corporate model, and nearly 75% of consumers in the United States purchase organic foods occasionally. To assess consumers' knowledge of locally grown organic foods, surveys were administered at three metropolitan farmers' markets in Little Rock, Hot Springs, and Texarkana, Arkansas. Consumers with Bachelor's, Associate's, or technical degrees accounted for almost half of the people surveyed. Seventy-one percent believed organic foods were safer than conventional foods. Three times as many consumers were concerned about harmful bacteria in conventional foods than in organic. The number one reason for purchasing was to support local farmers.
A Statistical Approach to Continuous Self-Calibrating Eye Gaze Tracking\n for Head-Mounted Virtual Reality Systems (2016)

We present a novel, automatic eye gaze tracking scheme inspired by smooth\npursuit eye motion while playing mobile games or watching virtual reality\ncontents. Our algorithm continuously calibrates an eye tracking system for a\nhead mounted display. This eliminates the need for an explicit calibration step\nand automatically compensates for small movements of the headset with respect\nto the head. The algorithm finds correspondences between corneal motion and\nscreen space motion, and uses these to generate Gaussian Process Regression\nmodels. A combination of those models provides a continuous mapping from\ncorneal position to screen space position. Accuracy is nearly as good as\nachieved with an explicit calibration step.\n
CD4+CD25+ cell depletion from the normal CD4+ T cell pool prevents tolerance toward the intestinal flora and leads to chronic colitis in immunodeficient mice (2006)

CD4+CD25+ regulatory T cells have been shown to prevent immune-mediated colitis in mice; however, it is unclear whether the absence of CD4+CD25+ in the normal CD4+ T cell pool is responsible for the development of chronic colitis. Using the T cell-deficient Tgepsilon26 mouse model, we show that CD4+CD25- cells but not CD4+CD25+ cells induce a severe intestinal inflammation. Transfer of CD4+CD25+ cells, together with CD4+CD25- cells, ameliorated intestinal inflammation, and reconstitution with the whole mesenteric lymph node cell pool did not induce colitis in recipients. Transferred CD4+CD25- cells were found mainly in the mesenteric lymph nodes, where they showed an activated TH1-like phenotype. In the absence of regulatory CD4+CD25+ T cells, recipient CD4 cells secreted IFN-gamma in response to stimulation with intestinal bacterial antigen that was prevented in vivo and in vitro by regulatory CD4+CD25+ cells. These studies suggest that CD4+CD25- cells have a strong colitogenic effect in the Tgepsilon26 colitis model and that CD4+CD25+ cells may be the main regulators that prevent or downregulate the proinflammatory effect of colitogenic T cells in the Tgepsilon26 mouse model.