gebhart/patrepeval huggingface dataset:
18F-Fluorination of Unactivated C–H Bonds in Branched Aliphatic Amino Acids: Direct Synthesis of Oncological Positron Emission Tomography Imaging Agents (2017)

A mild and selective photocatalytic C-H <sup>18</sup>F-fluorination reaction has been developed that provides direct access to <sup>18</sup>F-fluorinated amino acids. The biodistribution and uptake of three <sup>18</sup>F-labeled leucine analogues via LAT1 mediated transport in several cancer cell lines is reported. Positron emission tomography imaging of mice bearing PC3 (prostate) or U87 (glioma) xenografts using 5-[<sup>18</sup>F]-fluorohomoleucine showed high tumor uptake and excellent tumor visualization, highlighting the utility of this strategy for rapid tracer discovery for oncology.
EFFECT OF HIP PAD WITH AIR CUSHIONS AGAINST FRACTURE OF ELDERLY FEMURS IN FALLS(3C3 Bone & Ligament II) (2007)

The risks of fracture in femoral neck and trochanteric region by fa11s are high in aged peeple because of low bone mineral
Fast estimation of bifurcation conditions using noisy response data (2010)

In this work we consider the effects of noise on system behavior during parameter sweeps through bifurcations that induce sharp jumps in response amplitudes. These problems arise in a variety of applications, including the use of bifurcation amplification in micro-sensors. Due to inherent system noise, the observed bifurcation events are stochastic in nature and one must estimate parameter values from a distribution. A stochastic dynamical systems analysis allows one to distill the problem to a one-dimensional, one-parameter Fokker-Planck equation, where the parameter is the ratio of the noise intensity to sweep rate. Approximate closed form solutions for the distributions are obtained in the limits of slow and fast parameter sweep rates, and a numeric solution captures the intermediate sweep range that bridges these two approximations. These results are essential for quantifying errors in bifurcation amplifiers and for optimizing bifurcation detection schemes, as used in sensing applications. Preliminary experimental results for a parametrically excited microdevice show good qualitative agreement with the theory.
[Effectiveness of a modified parent training of smaller groups and shorter schedules for children with pervasive developmental disorders]. (2013)

Our findings provides additional evidence for the usefulness of PTSS for children with PDD.
A New Polystyrene–Poly(vinylpyridinium) Ionic Copolymer Dopant for n‐Type All‐Polymer Thermoelectrics with High and Stable Conductivity Relative to the Seebeck Coefficient giving High Power Factor (2022)

A novel n-type copolymer dopant polystyrene-poly(4-vinyl-N-hexylpyridinium fluoride) (PSpF) with fluoride anions is designed and synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. This is thought to be the first polymeric fluoride dopant. Electrical conductivity of 4.2 S cm<sup>-1</sup> and high power factor of 67 µW m<sup>-1</sup> K<sup>-2</sup> are achieved for PSpF-doped polymer films, with a corresponding decrease in thermal conductivity as the PSpF concentration is increased, giving the highest ZT of 0.1. An especially high electrical conductivity of 58 S cm<sup>-1</sup> at 88 °C and outstanding thermal stability are recorded. Further, organic transistors of PSpF-doped thin films exhibit high electron mobility and Hall mobility of 0.86 and 1.70 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> , respectively. The results suggest that polystyrene-poly(vinylpyridinium) salt copolymers with fluoride anions are promising for high-performance n-type all-polymer thermoelectrics. This work provides a new way to realize organic thermoelectrics with high conductivity relative to the Seebeck coefficient, high power factor, thermal stability, and broad processing window.
Correlation between Chemical Composition of Greek Essential Oils and their Antibacterial Activity against Food-borne Pathogens (2007)

The compositions of forty-nine essential oils obtained from plants growing in areas of biodiversity in Greece were determined by means of gas chromatography and gas chromatography–mass spectrometry. The in vitro antibacterial activities of the oils were evaluated against a panel of five common food-borne bacteria ( Escherichia coli 0157:H7 NCTC 12900, Salmonella Enteritidis PT4, Staphylococcus aureus ATCC 6538, Listeria monocytogenes Scott A and Bacillus cereus FSS 134). Monoterpene hydrocarbons, phenolic monoterpenes and alcohols were the major constituents of the oils, but their concentrations varied greatly between the samples examined. The essential oils obtained from the species endemic to Greece ( Satureja and Origanum) had the most potent bactericidal properties. The chemical composition data were statistically processed through Principal Component Analysis (PCA) and correlated with the antibacterial activities, allowing a rough estimation of the potential of the essential oils antibacterial activity.
Unifying Cloud and Carrier Network: EU FP7 Project UNIFY (2013)

Telecom providers struggle with low service flexibility, increasing complexity and related costs. Although "cloud" has been an active field of research, there is currently little integration between the vast networking assets and data centres of telecom providers. UNIFY considers the entire network, from home networks up to data centre, as a "unified production environment" supporting virtualization, programmability and automation and guarantee a high level of agility for network operations and for deploying new, secure and quality services, seamlessly instantiatable across the entire infrastructure. UNIFY focuses on the required enablers and will develop an automated, dynamic service creation platform, leveraging fine-granular service chaining. A service abstraction model and a proper service creation language and a global orchestrator, with novel optimization algorithms, will enable the automatic optimal placement of networking, computing and storage components across the infrastructure. New management technologies based on experience from DCs, called Service Provider DevOps, will be developed and integrated into the orchestration architecture to cope with the dynamicity of services. The applicability of a universal node based on commodity hardware will be evaluated in order to support both network functions and traditional data centre workloads, with an investigation of the need of hardware acceleration.
Augmented desensitization to epidermal growth factor (EGF) immediate actions: A novel mechanism for altered EGF growth response in mutant A431 cells (1990)

Epidermal growth factor (EGF) may either stimulate or inhibit cell growth. To elucidate the mechanism of these varied effects, we compared EGF action in parental A431 cells in which cell growth is inhibited, and clone 15, a mutant of these cells resistant to EGF growth inhibition. In both lines, EGF receptor was present in similar concentrations and underwent tyrosine phosphorylation to the same extent. Likewise, in both lines, acute exposure to EGF stimulated an increase in free cytoplasmic [Ca2+], as well as a similar increase in phosphorylation of lipocortin 1, a major substrate for the EGF receptor kinase whose phosphorylation is calcium-dependent. On the other hand, pretreatment of clone 15 cells with EGF for 72 h abolished EGF-induced phosphorylation of lipocortin 1 and led to a loss of the increase in cytoplasmic free [Ca2+], whereas no such desensitization was seen in the parental A431 cells. These data indicate a link between EGF-induced increase in cytoplasmic calcium, lipocortin phosphorylation, and cell growth and suggest that differences in mechanisms of desensitization to these immediate actions of EGF may lead to altered growth response to this hormone.
Loss of CD10 (neutral endopeptidase) is a frequent and early event in human prostate cancer (2003)

These findings demonstrate that loss or decreased expression of CD10 is an early and frequent event in human prostate cancer and implicates CD10 as a potential therapeutic target for early stage hormone sensitive prostate cancer.
No More Inefficient Crude Desalting - Breaking Bottleneck with Dual Frequency Technology Lowering Total Cost of Ownership (2022)

Abstract Historically, the engineering and operations teams in refineries have been constantly challenged to deploy efficient solutions for their crude desalting processes as part of the crude distillation unit (CDU). Inefficient crude oil desalting employing AC technology leads to higher utility consumption and corrosion-related issues with downstream equipment that create multiple bottlenecks while processing opportunity crudes. In addition, these challenges lead to a significant increase in operating expenses due to processing upsets and subsequent downtime. A major independent crude oil refinery in Asia is processing crude oil in two CDUs utilizing an AC technology desalting system. The total design capacity for the CDU is 206,000 BPD. The first CDU desalting equipment is designed for 150,000 BPD, and the second CDU is designed for 56,000 BPD. Both CDUs were operated in a range of 10 to 30 PTB inlet salinity. However, due to inefficient desalting, less than 60% desalting efficiency was achieved for each train with subsequent low dehydration efficiency. This led to a considerable bottleneck with the processing capacity and much higher chemical consumption, accompanied by frequent upsets and operational issues on downstream equipment. After a review of the entire desalting operations, the CDU 1 desalter vessel was upgraded to dual frequency technology, and a new dual frequency desalter was installed at the second stage of CDU 2. This change provided a paradigm shift in handling opportunity crude blends in the range of crude density 21 to 28° API with the flexibility of 20 to 100 PTB inlet salinity. After the upgrade, the CDUs achieved a desalting efficiency of more than 90% on each stage and more than 99% on two stages. This paper examines the project from early engagement through conceptual technology selection phase, engineering design, and project execution leading to a successful startup backed by operational history. Furthermore, the adoption of dual frequency technology over legacy AC technology demonstrates the twin goals of positive economic and environmental stewardship, thereby lowering the total cost of ownership to the customer. The CDU 1 dual frequency technology retrofit has been in continuous operation since 2019 and performing well within the PTB outlet specifications. The system is running with 40 to 50 % lower utility consumption, both chemical and power savings with reduced downstream corrosion and an increase in uptime reliability.
Antibacterial Activity of Stilbene Oligomers against Vancomycin-Resistant Enterococci (VRE) and Methicillin-Resistant Staphylococcus aureus (MRSA) and Their Synergism with Antibiotics (2007)

Two resveratrol trimers, gnemonol B isolated from Gnetum gnemon and gnetin E obtained from the Gnetum species, were found to exhibit strong antibacterial activities against vancomycin-resistant Enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). The MIC values of gnemonol B against five strains of VRE and nine strains of MRSA were 12.5 and 6.25 microg/ml, respectively. The MIC values of gnetin E against five strains of VRE and nine strains of MRSA ranged from 12.5 to 25microg/ml. These compounds also showed synergistic effects when used in combination with commercially available antibiotics according to the evaluation method using FIC indices. These findings suggested that the application of the test compounds alone or in combination with antibiotics might be useful in controlling and treating VRE and MRSA infections
Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI (2015)

We identified 4 novel genetic loci that implicate inflammatory and glial proliferative pathways in the development of WMH in addition to previously proposed ischemic mechanisms.
Empirical Measurements on Pricing Oracles and Decentralized Governance for Stablecoins (2021)

Stablecoins are designed to address the volatility of crypto assets by maintaining a peg to a non-volatile currency such as the US Dollar. Decentralized Stablecoins that maintain their collateral on-chain need a pricing oracle to determine the current market value of the collateral. They also employ a decentralized governance system to make policy changes. In this paper, we analyze the inner-workings of the pricing oracle and the decentralized governance mechanism employed in the MakerDAO stablecoin, one of the largest and fully developed on-chain stablecoins. We study the accuracy of the pricing oracle over time, as well as disagreements between pricing reports received by MakerDAO. We also study the robustness of the decentralized governance system. This work sheds detailed light on the practical operation of a pricing oracle and a decentralized governance mechanism in a large deployed system. We make a number of recommendations for improvements based on our findings.
<title>Wire transfer of charge packets for on-chip CCD signal processing</title> (1990)

A structure for the virtual transfer of charge packets across metal wires is described theoretically and is experimentally verified. The structure is a hybrid of charge-coupled device (CCD) and bucket-brigade device (BBD) elements and permits the topological crossing of charge-domain signals in low power signal processing circuits. A test vehicle consisting of 8-, 32- and 96-stage delay lines of various geometries implemented in a double-poly, double-metal foundry process was used to characterize the wire-transfer operation. Transfer efficiency ranging between 0.998 and 0.999 was obtained for surface n-channel devices with clock cycle times in the range from 40 nsec to 0.3 msec. Transfer efficiency as high as 0.9999 was obtained for buried n-channel devices. Good agreement is found between experiment and simulation.
THE ITINERANT ORCHESTRA, A 5G, MULTI-CAMERA, REMOTE AND DISTRIBUTED VIDEO PRODUCTION EXPERIMENT (2021)

This paper presents the implementation of the Itinerant Orchestra use case, a technical and artistic challenge, in which musicians located in a main concert hall play together with other itinerant musicians walking in the streets of Turin, Italy, while approaching the concert hall. Audio-Video signals of the itinerant musicians are transmitted via a 5G network to the main editing site where they are properly processed and mixed with the orchestra located in the concert hall. The architecture for the outdoor and indoor 5G network coverage, the integration of the technical solution for the television remote production, and relevant collected measures and KPI analysis from the network and functional perspectives are also described in this paper.
A Morphological Study of the Meniscus, Cartilage and Subchondral Bone Following Closed-Joint Traumatic Impact to the Knee (2022)

Post-traumatic osteoarthritis (PTOA) is a debilitating disease that is a result of a breakdown of knee joint tissues following traumatic impact. The interplay of how these tissues influence each other has received little attention because of complex interactions. This study was designed to correlate the degeneration of the menisci, cartilage and subchondral bone following an acute traumatic event that resulted in anterior cruciate ligament (ACL) and medial meniscus tears. We used a well-defined impact injury animal model that ruptures the ACL and tears the menisci. Subsequently, the knee joints underwent ACL reconstruction and morphological analyses were performed on the menisci, cartilage and subchondral bone at 1-, 3- and 6-months following injury. The results showed that the morphological scores of the medial and lateral menisci worsened with time, as did the tibial plateau and femoral condyle articular cartilage scores. The medial meniscus was significantly correlated to the medial tibial subchondral bone at 1 month (<i>p</i> = 0.01), and to the medial tibial cartilage at 3 months (<i>p</i> = 0.04). There was only one significant correlation in the lateral hemijoint, i.e., the lateral tibial cartilage to the lateral tibial subchondral bone at 6 months (<i>p</i> = 0.05). These data may suggest that, following trauma, the observed medial meniscal damage should be treated acutely by means other than a full or partial meniscectomy, since that procedure may have been the primary cause of degenerative changes in the underlying cartilage and subchondral bone. In addition to potentially treating meniscal damage differently, improvements could be made in optimizing treatment of acute knee trauma.
Accompaniment separation and karaoke application based on automatic melody transcription (2008)

We propose a method for separating accompaniment from polyphonic music and its karaoke application, both based on automatic melody transcription. First, the method transcribes the lead-vocal melody of an existing polyphonic music piece, where the transcription consists of a MIDI note sequence and a detailed fundamental frequency (F0) trajectory for each note. Based on the note F0 trajectories, the method uses sinusoidal modeling to estimate, synthesize, and remove the lead vocals in the piece, thus producing separated accompaniment of the piece. User sings along with the separated accompaniment similar to karaoke while the user singing can be tuned to the transcribed melody. This will help non-professional singers to produce more appealing karaoke performances. The quality of separated accompaniments was quantitatively evaluated with approximately one hour of polyphonic music, including material from a commercial karaoke DVD.
An Inverse Aluminum Battery: Putting the Aluminum as the Cathode (2017)

Aluminum has long been regarded as a promising anode for energy storage because of its high energy density and low cost, but its application is hindered by the inability of cathodes to provide reversible Al3+ insertion. In contrast, we show how the use of Al as cathode enables a rechargeable high-energy battery. The battery comprises a molten sodium anolyte and a molten NaAl2Cl7 catholyte, separated by a NaSICON solid Na+ electrolyte. It is operated at 200 °C to overcome the ceramic separator kinetics and to keep sodium and NaAl2Cl7 in the molten state. Because of the simple composition and trivalence of Al, the sodium anolyte and NaAl2Cl7 catholyte together show a high energy density of 366 Wh kg–1, although its voltage is only about 1.55 V and only 60% of the capacity can be realized. The high energy density, low-cost, and internal safety make this new cell chemistry applicable to the large-scale energy storage market.
Does non-orthogonal spectrum sharing in the same cell improve the sum-rate of wireless operators? (2012)

We study non-orthogonal spectrum sharing to determine under what circumstances operators can gain by such sharing. To model the spectrum sharing, we use the multiple-input single-output (MISO) interference channel (IC) assuming that the operators transmit in the same band. For the baseline scenario of no sharing, we use the MISO broadcast channel (BC) assuming that the operators transmit in disjunct bands. For both the IC and BC, we give achievable (lower) and upper bounds on the maximum sum-rate. While these bounds are well-known we also propose a new fast algorithm for finding a lower bound on the sum-rate of the BC using linear beamforming. We use the bounds to numerically evaluate the potential gain of non-orthogonal spectrum sharing. In this study we assume that the operators efficiently utilize all their spatial degrees of freedom. We will see that the gains from spectrum sharing under these circumstances are limited.
L'-band AGPM vector vortex coronagraph's first light on LBTI/LMIRCam (2014)

We present the first observations obtained with the L'-band AGPM vortex coronagraph recently installed on LBTI/LMIRCam. The AGPM (Annular Groove Phase Mask) is a vector vortex coronagraph made from diamond subwavelength gratings. It is designed to improve the sensitivity and dynamic range of high-resolution imaging at very small inner working angles, down to 0.09 arcseconds in the case of LBTI/LMIRCam in the L' band. During the first hours on sky, we observed the young A5V star HR8799 with the goal to demonstrate the AGPM performance and assess its relevance for the ongoing LBTI planet survey (LEECH). Preliminary analyses of the data reveal the four known planets clearly at high SNR and provide unprecedented sensitivity limits in the inner planetary system (down to the diffraction limit of 0.09 arcseconds).
1.5T MRI-guided trans-perineal laser ablation of locally recurrent prostate adenocarcinoma (2010)

Introduction: Biochemical recurrence of prostate cancer after definitive therapy with radical prostatectomy (RP) is known to occur between 25-30%. We present the first known case of 1.5T MRI guided ablation using laser interstitial thermal therapy (LITT) for locally recurrent prostate cancer following RP. Methods: The patient elected to undergo MRI-guided LITT of the biopsy proven cancer recurrence using an FDAapproved MRI compatible, 980nm, 15-watt laser system with MR thermometry. Under T2-weighted MR(1.5T Siemens) imaging, guidance and targeting of the lesions with trans-perineal placement of laser applicators. Multiple cycles of laser energy were used to ablate the tumor. A MRI-compatible urethral cooling catheter was placed to prevent urethral thermal damage. Results: Intra-procedural temperature mapping allowed continuous monitoring of the ablation zone and permitted ablation control until tumor coverage was achieved. Additionally, the protective cooling effects of the urethral cooling catheter could also be seen with the temperature mapping. Post-ablation gadolinium and T2 weighted MR imaging demonstrated an ablation defect encompassing the recurrent tumor with no residual hyper-enhancing nodules. Three month follow-up shows no residual or recurrent tumor seen on MR imaging. Conclusion: This represents the first known, successful, MRI-guided, LITT procedures at 1.5T for locally recurrent prostate adenocarcinoma following RP.
Microheterogeneity in regulatory circuits for T-cell alloresponsiveness. (1981)

Mixed leucocyte cultures of responder spleen cells from individual B10 mice, challenged with irradiated allogeneic B10.D2 or B10.BR spleen cells, were used to generate discrete pools of cytotoxic T lymphocytes (CTL) with which to immunize (B10 x B10.D2)F1 or (B10 x B10.BR)F1 animals. Aliquots of the original donor B10 spleen cells were stored at -70 degrees. Eighteen days after immunization of the F1 animals, spleen and serum preparations from these mice were tested, in reciprocal fashion, for their ability to affect the development of CTL from the thawed donor B10 spleen lymphocytes in fresh cultures challenged with either the original or a third party allogeneic stimulus. Evidence for individual specific suppression by F1-T lymphocytes or by F1-serum (antibody) molecules was obtained. By priming (B10 x B10.D2)F1 mice with B10 lymphoid cells the F1 animals can also be shown to resist the otherwise lethal GvHD induced by sublethal whole body irradiation followed by intravenous challenge with B10 lymphoid cells. Using F1 mice primed and subsequently challenged with lymphocytes prepared from individual donors, self-preference in the regulation of GvHD was also seen. A similar fine specificity of regulatory cells was observed using suppressor cells from individual mice rendered neonatally tolerant of histocompatible cells (by inoculation of F1 hybrid cells within 24 hr of birth). These findings suggest that the mouse T cell alloreceptor repertoire is subject to a process of somatic diversification during normal ontogenesis. By examining the regulation of alloresponsiveness in T lymphocytes of B10.Br origin which differentiate from the appropriate stem cells in a B10 or B10.Br host, we have uncovered evidence that the T-cell alloreceptor repertoire is, in part at least, determined by the host MHC environment.