gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Cation‐Directed Dimeric versus Tetrameric Assemblies of Lanthanide‐Stabilized Dilacunary Keggin Tungstogermanates. (2014)

Abstract Reaction of mid‐ to late lanthanide(III) ions with GeO 2 and Na 2 WO 4 in NaOAc buffer solution results in a series of [Ln 2 (GeW 10 O 38 )] 6‐ clusters.
Development and in Vivo Quantitative Magnetic Resonance Imaging of Polymer Micelles Targeted to the Melanocortin 1 Receptor (2013)

Recent emphasis has focused on the development of rationally designed polymer-based micelle carriers for drug delivery. The current work tests the hypothesis that target specificity can be enhanced by micelles with cancer-specific ligands. In particular, we describe the synthesis and characterization of a new gadolinium texaphyrin (Gd-Tx) complex encapsulated in an IVECT micellar system, stabilized through Fe(III) cross-linking and targeted with multiple copies of a specific ligand for the melanocortin 1 receptor (MC1R), which has been evaluated as a cell-surface marker for melanoma. On the basis of comparative MRI experiments, we have been able to demonstrate that these Gd-Tx micelles are able to target MC1R-expressing xenograft tumors in vitro and in vivo more effectively than various control systems, including untargeted or un-cross-linked Gd-Tx micelles. Taken in concert, the findings reported herein support the conclusion that appropriately designed micelles are able to deliver contrast agent payloads to tumors expressing the MC1R.
On Symmetric Gauss–Seidel ADMM Algorithm for H∞ Guaranteed Cost Control With Convex Parameterization (2022)

This article involves the innovative development of a symmetric Gauss–Seidel ADMM algorithm to solve the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mathcal {H}_{\infty }$ </tex-math></inline-formula> guaranteed cost control problem. In the presence of parametric uncertainties, the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mathcal {H}_{\infty }$ </tex-math></inline-formula> guaranteed cost control problem generally leads to the large-scale optimization. This is due to the exponential growth of the number of the extreme systems involved with respect to the number of parametric uncertainties. In this work, through a variant of the Youla–Kucera parameterization, the stabilizing controllers are parameterized in a convex set; yielding the outcome that the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mathcal {H}_{\infty }$ </tex-math></inline-formula> guaranteed cost control problem is converted to a convex optimization problem. Based on an appropriate reformulation using the Schur complement, it then renders possible the use of the ADMM algorithm with symmetric Gauss–Seidel backward and forward sweeps. Significantly, this approach alleviates the often-times prohibitively heavy computational burden typical in many <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mathcal H_{\infty }$ </tex-math></inline-formula> optimization problems while exhibiting good convergence guarantees, which is particularly essential for the related large-scale optimization procedures involved. With this approach, the desired robust stability is ensured, and the disturbance attenuation is maintained at the minimum level in the presence of parametric uncertainties. Rather importantly too, with the attained effectiveness, the methodology thus evidently possesses extensive applicability in various important controller synthesis problems, such as decentralized control, sparse control, and output feedback control problems.
Grape‐Enriched Diets Alter Cardiac Pathology and Cardiac Glutathione Dynamics in Hypertensive Rats (2009)

Increased fruit and vegetable intake can reduce hypertension, but its effect upon hypertensive cardiac pathology is unknown. This relationship was tested in the Dahl‐Salt Sensitive rat fed a high‐salt diet. Provision of 3% (w:w) whole table grape powder for 18 weeks reduced blood pressure, reduced cardiac hypertrophy, improved cardiac function, and increased cardiac glutathione, a key endogenous antioxidant. Provision of vasodilator hydralazine matched the blood pressure reduction of grape but failed to similarly reduce cardiac pathology. In vitro, phytochemicals found in grapes can alter genes related to Phase I/II metabolism, impacting glutathione dynamics. However, cardiac effects with a whole food are unknown. RT‐PCR analysis indicated that grape provision altered genes for oxidoreductases, transferases, sulfotransferases and peroxidases which affect glutathione dynamics, which on balance, would favor elevated glutathione. Key expression changes are confirmed by immunoblot. Importantly, these changes were conserved in grape‐fed, healthy (low‐salt fed) rats, further supporting the nutrigenomic effects of grape intake. In conclusion, physiologically relevant phytochemical intake reduced hypertensive cardiac pathology and altered cardiac transcripts related to glutathione dynamics, which may be vital to its cardioprotective effects. California Table Grape Commission, NIH‐NHLBI. Grant Funding Source NIH‐NHLBI, California Table Grape Commission
Author response: Identification of a pre-active conformation of a pentameric channel receptor (2017)

Allosteric reorganizations of a bacterial channel receptor are mapped along the protein structure, using the site-directed bimane quenching fluorescence technique, through parallel real-time conformational and electrophysiological recordings.
Thermoelectric Behavior of Segregated-Network Polymer Nanocomposites (2009)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionThermoelectric Behavior of Segregated-Network Polymer NanocompositesChoongho Yu*, Yeon Seok Kim, Dasaroyong Kim, and Jaime C. Grunlan*Cite this: Nano Lett. 2009, 9, 3, 1283Publication Date (Web):February 23, 2009Publication History Received25 January 2009Published online23 February 2009Published inissue 11 March 2009https://pubs.acs.org/doi/10.1021/nl900263dhttps://doi.org/10.1021/nl900263dcorrectionACS PublicationsCopyright © 2009 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1896Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (22 KB) Get e-AlertscloseSUBJECTS:Carbon nanotubes,Impurities,Mixtures,Nanocomposites,Nanotechnology Get e-Alerts
Muscle Proteins as High Speed Nano Transporters on Micro Patterns (2006)

This paper describes a biohybrid nano transporting device using muscle proteins of actin and myosin. These proteins are patterned on a glass substrate by a Parylene lift off process. A nano fluorescent particle was attached onto an actin filament by biotin-avidin interactions. We found that the actin filament is sufficiently flexible, so it can turn back at the edge of the pattern and is confined moving upon the micro patterns. The velocity of the transportation was around 4 µ m/s, which was about 40 times faster than that of kinesin and microtubule we used in MEMS2005 [ 1a]. This technique is useful for high speed transportation or actuation of MEMS/NEMS devices.
Advanced Oxy-combustion Technology for Pulverized Bituminous Coal Power Plants (2017)

The main objective of this study is to examine atmospheric pressure oxy-combustion technology options that have the largest potential to increase the system performance and/or to reduce the cost of electricity (COE). The costs and performances of the O2 production technology and the CO2 compression and purification system have the largest and most direct influence on the incremental costs associated with carbon capture using oxy-combustion technology. Other general process parameter improvements that enhance system efficiency also have a supplemental, albeit secondary, benefit on the costs by reducing the O2 demand and the CO2 throughput for a given power output. Accordingly, a total of eight advanced oxy-combustion systems based on advances in the four major areas of boiler design, oxygen production, flue gas treatment, and innovative CO2 compression concepts were compared to a base case that reflects current oxy-combustion technology.
Effect of Transmission-Line Contact Length on the 50-Gbit/s Data Encoding Performance of a Multimode VCSEL (2022)

Directly modulated 850-nm multimode vertical-cavity surface-emitting lasers (MM-VCSELs) with different oxide apertures and transmission microstrip lengths are compared on the transmission performance of the non-return-to-zero on-off keying (NRZ-OOK) and four-level pulse amplitude modulation (PAM-4) data formats. In this work, intrinsic and extrinsic responses of the MM-VCSEL are also discussed concurrently. By tuning the length of the transmission microstrip in VCSEL, the low reflection coefficient and the enhanced 3-dB modulation bandwidth are achieved. The inductance of the transmission microstrip in the series connection with the capacitance in the active region is optimized to reduce the power loss induced by imaginary impedance. The different oxide aperture sizes for MM-VCSEL are also studied to control the capacitance and photon density. More importantly, the 3-dB modulation bandwidth, impedance matching, slope efficiency, relative intensity noise (RIN), and mode partition noise (MPN) for the MM-VCSEL with various designs are discussed to determine the best device with the high-speed transmission capability. The optimal MM-VCSEL with a diameter of 7 µm oxide aperture and a length of 25 µm transmission microstrip successfully demonstrates 50-Gbit/s OOK and 84-Gbit/s PAM4 after using the pre-emphasis technique for future data-center applications.
Learning From Sleeping Experts (2018)

We consider a generalized model of learning from expert advice in which experts could abstain from participating at some rounds. Our proposed online algorithm falls into the class of weighted average predictors and uses a time-varying multiplicative weight update rule. This update rule changes the weight of an expert based on his or her relative performance compared to the average performance of available experts at the current round. This makes the algorithm suitable for recommendation systems in the presence of an adversary with many potential applications in the new emerging area of the Internet of Things. We prove the convergence of our algorithm to the best expert, defined in terms of both availability and accuracy, in the stochastic setting. In particular, we show the applicability of our definition of best expert through convergence analysis of another well-known algorithm in this setting. Finally, through simulation results on synthetic and real datasets, we justify the out-performance of our proposed algorithms compared to the existing ones in the literature.
Der Fernseher in der Westentasche: Flüssigkristall‐ Materialentwicklung für das neue Jahrtausend (2013)

Abstract Neue Flüssigkristalle mit sehr niedriger Viskosität, gutem Mesophasenverhalten und hoher Zuverlässigkeit ermöglichen den Durchbruch vom flachen Computermonitor zum großformatigen LCD‐Fernseher. Fluor spielt hierbei eine entscheidende Rolle, nicht nur, weil es Polarität in organischen Molekülen induziert, sondern auch wegen seiner niedrigen Polarisierbarkeit und seiner schwach ausgeprägten Tendenz zur Ionensolvatation. Zusätzlich sind in fluorierten Flüssigkristallen subtile stereoelektronische Effekte am Werk und ermöglichen eine Feinabstimmung der gewünschten Eigenschaften. Dafür ist eine aufwendige Chemie erforderlich, wie sie sich normalerweise in der Spezialchemie allein schon aus Kostengründen verbietet. Der Markt für Fernseh‐Displays tritt heute in eine Phase der Sättigung ein. Bedingt durch die weite Verbreitung des Internets gibt es jedoch einen neuen Trend zu mobilen Geräten. Tablet‐PCs und Smartphones benötigen berührungsempfindliche Bildschirme und niedrigen Stromverbrauch. Neue LC‐Modi mit hocheffizienten Flüssigkristallen und zusätzlichen Komponenten, z. B. polymerisierbaren Materialien, werden in solchen Produkten verwendet.
Effect of an annular sleeve of high permittivity material on resonant modes and homogeneity of a birdcage coil (2015)

We investigated how high permittivity materials affect the S-parameters and transmit efficiency of a head-sized birdcage coil. We also studied whether re-tuning and matching are necessary for improved performance. While adjusting the S-parameters is possible during coil development and for prototype coils, it is often unfeasible to re-tune and match commercially manufactured coils, and poses a challenge after adding dielectric material to such coils. Our work demonstrates the change in the S-parameters and the transmit efficiency after placing a dielectric sleeve within a head-sized birdcage coil, and reports that coil performance can be improved after re-tuning and matching the coil in the presence of the dielectric material.
Endoscopic autofluorescence micro-spectroimaging of alveoli: comparative spectral analysis of amiodarone-induced pneumonitis patients and healthy smokers (2011)

International audience
Microwave Gas Breakdown in Tunable Evanescent-Mode Cavity Resonators (2014)

Microwave gas breakdown in strongly-coupled evanescent-mode cavity resonators in atmospheric pressure and room temperature is investigated both numerically and experimentally. This high- Q resonator is widely tunable by changing the gap between its loading post and top wall. In this letter, we study the effect of different gap spacings on breakdown characteristics of this resonator. Good agreement is observed between measured breakdown powers and ones by plasma simulations for resonators with gaps of 14.8-51.2 μm, working in the 6-8.25 GHz frequency range with input breakdown power in the range of 45-48 dBm.
Three-dimensional viscous confinement and cooling of atoms by resonance radiation pressure (1985)

We report the viscous confinement and cooling of neutral sodium atoms in three dimensions via the radiation pressure of counterpropagating laser beams. These atoms have a density of about \ensuremath{\sim}${10}^{6}$ ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}3}$ and a temperature of \ensuremath{\sim}240 \ensuremath{\mu}K corresponding to a rms velocity of \ensuremath{\sim}60 cm/sec. This temperature is approximately the quantum limit for this atomic transition. The decay time for half the atoms to escape a \ensuremath{\sim}0.2${\mathrm{cm}}^{3}$ confinement volume is \ensuremath{\sim}0.1 sec.
119302 Method of Displaying Tactile using Ultrasonic Vibration for Active Touch (2011)

When we display the texture of virtual 3D objects, it is required to display both tactile and force information at the same time. Although some force displays are commercially available, a wearable tactile display should be realized display tactile information together with force information. Hence this paper proposes a novel wearable tactile display aiming for the integration with force display. Active touch is required to display tactile information more sensitively. That means it is need to recreate active touch when we display tactile information using wearable tactile display. To realize such a device, we used the squeeze film effect for tactile display, occurred by an ultrasonic vibration. In addition to this, we propose to move a sheet between finger and ultrasonic vibrator. First, we develop device using the method we propose. Then, we verified the usability of the wearable tactile display by experiments.
Peripheral Vascular Actions of -Methyl-DOPA and Its Mode of Action on Arterioles (1974)

SummaryThe present quantitative in vivo and in vitro experiments on rat mesenteric arterioles and aortas, respectively, demonstrate that although α-methylnorepinephrine is much less potent than epinephrine on both types of blood vessels, it is only 1.5-2 times less potent than the natural postganglionic neurotransmitter norepinephrine on these blood vessels. Furthermore, α-methylnorepinephrine is equivalent to norepinephrine in its ability to induce maximal contractile responses on rat arterioles and aortas. Systemic administration of α-methyl-DOPA to rats for 15 days shifted the log dose–response curves for all three catecholamines, but not vasopressin, to the right on both intact 20-30 μm arterioles and isolated aorta; the maximal contractile responses to these amines were, however, not affected by chronic treatment with α-methyl-DOPA. In addition, acute, intra-arterial administration of 500 mg/kg of α-methyl-DOPA was found to not only gradually induce mesenteric arteriolar vasodilatation, but to depres...
Fabrication of a Multidomain and Ultrafast‐Switching Liquid Crystal Alignment Layer Using Contact Printing with a Poly(dimethylsiloxane) Stamp (2012)

A compartmentalized multidomain alignment state of a layer of liquid crystal display is achieved using an ultrathin, highly transparent, and ultrafast-responsive alignment layer fabricated by a simple method. The ultrathin alignment layer consists of a self-assembled oligomer layer of poly(dimethylsiloxane) (PDMS) formed by utilizing the oligomers that diffuse out from a PDMS elastomer stamp during a contact printing process.
Decorin-mediated Signal Transduction in Endothelial Cells (2001)

Endothelial cells undergoing angiogenesis express decorin, a small multifunctional proteoglycan. We have shown that decorin is causally involved in the formation of capillary-like structures and a decrease in apoptosis in endothelial cells cultured in a collagen lattice. Here we investigate signal transduction pathways mediating the effects of decorin. Reverse transcription-polymerase chain reaction demonstrated that p21 and p27, two inhibitors of cyclin-dependent kinases, were up-regulated by decorin induction. Decorin also increased protein levels of p21 and caused its translocation into the nucleus. p21 synthesis started 6 h after decorin addition and reached a plateau after 18 h, while cyclin A, which was also induced, peaked at 12 h and declined below basal levels within 24 h. These effects were mediated by the Akt/protein kinase B pathway. Akt phosphorylation at Thr-308 increased 4-fold and at Ser-473 1.4-fold within 10 min after decorin addition. Overexpression of dominant negative Akt inhibited the decorin-mediated induction of p21 and cyclin A, but had no effect on p27. These results show that decorin is a signaling molecule in sprouting endothelial cells where it acts via different pathways, one of them involving Akt/protein kinase B.
Active mechanical-environmental-thermal MEMS device for nanoscale characterization (2023)

A microelectromechanical system (MEMS) device can be used for quantitative mechanical testing of materials within a controlled (chemical and temperature) environment, with the ability for electrochemical control to the specimen, that is coupled with a complimentary in-situ characterization technique.
Identification of Fibroblast Growth Factor Receptor 3 (FGFR3) as a Protein Receptor for Botulinum Neurotoxin Serotype A (BoNT/A) (2013)

Botulinum neurotoxin serotype A (BoNT/A) causes transient muscle paralysis by entering motor nerve terminals (MNTs) where it cleaves the SNARE protein Synaptosomal-associated protein 25 (SNAP25206) to yield SNAP25197. Cleavage of SNAP25 results in blockage of synaptic vesicle fusion and inhibition of the release of acetylcholine. The specific uptake of BoNT/A into pre-synaptic nerve terminals is a tightly controlled multistep process, involving a combination of high and low affinity receptors. Interestingly, the C-terminal binding domain region of BoNT/A, HC/A, is homologous to fibroblast growth factors (FGFs), making it a possible ligand for Fibroblast Growth Factor Receptors (FGFRs). Here we present data supporting the identification of Fibroblast Growth Factor Receptor 3 (FGFR3) as a high affinity receptor for BoNT/A in neuronal cells. HC/A binds with high affinity to the two extra-cellular loops of FGFR3 and acts similar to an agonist ligand for FGFR3, resulting in phosphorylation of the receptor. Native ligands for FGFR3; FGF1, FGF2, and FGF9 compete for binding to FGFR3 and block BoNT/A cellular uptake. These findings show that FGFR3 plays a pivotal role in the specific uptake of BoNT/A across the cell membrane being part of a larger receptor complex involving ganglioside- and protein-protein interactions.
CONTENT BASED IMAGE RETRIEVAL USING DISCRETE WAVELET TRANSFORM (2004)

Image retrieval plays an important role in a broad spectrum of applications. Contentbased retrieval (CBR) is one of the popular choices in many biomedical and industrial applications. Discrete image transforms have been widely studied and suggested for many image retrieval applications. The Discrete Wavelet Transform (DWT) is one of the most popular transforms recently applied to many image processing applications. The Daubechies wavelet can be used to form the basis for extracting features in retrieving images based on the description of a particular object within the scene. This wavelet is widely used for image compression. In this paper we highlight the common features between compression and retrieval. Several examples are used to test the DWT retrieval system. A comparison between DWT and Discrete Cosine Transform (DCT) is also made. The retrieval system using DWT requires preprocessing and normalization of images, which might slow down the retrieval process. The accuracy of the retrieval using DWT has been significantly improved by incorporating efficient K-Neighbor Nearest Distance (KNND) measure in our system.
Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies (1987)

Abstract An abnormal increase in numbers of CCGG sites methylated in the 5′ region of the human calcitonin (CT) gene occurred in tumor cell DNA samples from 90% (17 of 19) of patients with non-Hodgkin's T and B cell lymphoid neoplasms and in 95% (21 of 22) of tumor cell DNA samples from patients with acute nonlymphocytic leukemia (ANLL). The changes were not seen in patients with chronic myelogenous leukemia (0 of 9). The abnormal methylation patterns appear to be a property only of transformed or malignant cells since they were not found in DNA from nonneoplastic adult tissues including sperm, early myeloid progenitor cells, benign lymphoid hyperplasia, peripheral lymphocytes stimulated to divide, or early myeloid progenitor cells (obtained by immunoaffinity using anti-My-10 antibody), but they did appear after Epstein-Barr virus transformation of lymphocytes. Moreover, during the course of therapy in patients with ANLL, the hypermethylation pattern reflects the presence of the leukemic clone even in normal-appearing granulocytes derived from this clone. The increased methylation of the CT gene may then provide an important molecular marker for biologic events in human cell transformation or tumor progression and may prove clinically useful in monitoring patients with lymphoid and acute myelogenous neoplasms.