gebhart/patrepeval huggingface dataset:
Biodegradable silk catheters for the delivery of therapeutics across anatomical repair sites (2018)

Biodegradable silk catheters for the delivery of therapeutics are designed with a focus on creating porous gradients that can direct the release of molecules away from the implantation site. Though suitable for a range of applications, these catheters are designed for drug delivery to transplanted adipose tissue in patients having undergone a fat grafting procedure. A common complication for fat grafts is the rapid reabsorption of large volume adipose transplants. In order to prolong volume retention, biodegradable catheters can be embedded into transplanted tissue to deliver nutrients, growth factors or therapeutics to improve adipocyte viability, proliferation, and ultimately extend volume retention. Two fabrication methods are developed: a silk gel-spinning technique, which uses a novel flash-freezing step to induce high porosity throughout the bulk of the tube, and a dip-coating process using silk protein solutions doped with a water soluble porogen. Increased porosity aids in the diffusion of drug through the silk tube in a controllable way. Additionally, we interface the porous tubes with ALZET osmotic pumps for implantation into a subcutaneous nude mouse model. The work described herein will discuss the processing parameters as well as the interfacing between pump and cargo therapeutic and the resulting release profiles. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 501-510, 2019.
Analysis and enhancement of narrowband active noise control systems with disturbance (2016)

The disturbance at error sensors will degrade the performance of active noise control (ANC) systems, resulting in slow convergence and decreased noise reduction problems. This paper analyzes the disturbance effects on narrowband ANC (NANC) systems and proposes modified algorithm to enhance both the transient and steady-state performance. A delayless bandpass filterbank is designed to eliminate out-of-band disturbance in the generated individual error signals for updating the corresponding adaptive filters. The theoretical analysis and improved performance are verified by computer simulations using measured transfer functions from the experimental setup.
A position-insensitive finished store buffer (2007)

This paper presents the finished store buffer (or FSB), an alternative and position-insensitive approach for building a scalable store buffer for an out-of-order processor. Exploiting the fact that only a small portion of in-flight stores are done executing (i.e. finished) and waiting for retirement, we are able to build a much smaller and more scalable store buffer. Our study shows that we only need at most half of the number of entries in a conventional store queue if we buffer only the stores that have finished execution. Entries in the store buffer are allocated at issue and disallocated on retirement. A clever encoder circuit is used to provide positional searches without an explicitly positional queue structure. While reducing the access latency and power consumption significantly, our technique has virtually no detrimental effect on per-cycle performance (IPC).
Wavelength dispersion of 1D photonic crystals (2002)

Periodic multilayer film (the simplest 1D photonic crystal) is commonly utilized as wavelength splitting filters, because the multilayer structure has PBG(photonic band gaps) along the direction of lamination. Although the structure has no PBG along spreading directions, plural photonic bands make unique propagations of electromagnetic waves. A very large dispersion of refracted rays from the surfaces were experimentally observed and theoretically analyzed.
In vitro and in vivo expression of foreign genes by transmissible gastroenteritis coronavirus-derived minigenomes (2002)

A helper-dependent expression system based on transmissible gastroenteritis coronavirus (TGEV) has been developed using a minigenome of 3.9 kb (M39). Expression of the reporter gene beta-glucuronidase (GUS) (2-8 microg per 10(6) cells) and the porcine respiratory and reproductive syndrome virus (PRRSV) ORF5 (1-2 microg per 10(6) cells) has been shown using a TGEV-derived minigenome. GUS expression levels increased about eightfold with the m.o.i. and were maintained for more than eight passages in cell culture. Nevertheless, instability of the GUS and ORF5 subgenomic mRNAs was observed from passages five and four, respectively. About a quarter of the cells in culture expressing the helper virus also produced the reporter gene as determined by studying GUS mRNA production by in situ hybridization or immunodetection to visualize the protein synthesized. Expression of GUS was detected in the lungs, but not in the gut, of swine immunized with the virus vector. Around a quarter of lung cells showing replication of the helper virus were also positive for the reporter gene. Interestingly, strong humoral immune responses to both GUS and PRRSV ORF5 were induced in swine with this virus vector. The large cloning capacity and the tissue specificity of the TGEV-derived minigenomes suggest that these virus vectors are very promising for vaccine development.
Optical and Electrochemical Detection of Saccharides with Poly(aniline-co-3-aminobenzeneboronic acid) Prepared from Enzymatic Polymerization (2007)

Boronic acid-based sensors for saccharides have been developed via biocatalysis. The self-doped copolymer of poly(aniline-co-3-aminobenzeneboronic acid) [poly(aniline-co-AB)], with various mole ratios of two components, was synthesized by oxidative enzymatic polymerization using a natural biocatalyst such as horseradish peroxidase together with an anionic polyelectrolyte template (sulfonated polystyrene) under mild conditions (pH 4.5). Poly(aniline-co-AB), having an aniline boronic acid-to-aniline ratio of 1:2 on average, gave rise to a green doped polymer with absorption maxima at 745 nm. The potentiometric detection of saccharides using poly(aniline-co-AB) is presented. Characteristics of both transient and steady-state response associated with the complex formation of poly(aniline-co-AB) with various saccharides were monitored by UV-vis spectroscopy and cyclic voltammetry (CV). The results obtained from UV-vis spectroscopy and CV show that the sensitivity of enzymatically synthesized water-soluble poly(aniline-co-AB) for various saccharides was improved significantly compared to the chemically synthesized counterpart. A possible mechanism for the sensitive detection of sugar molecules by boronic acid is proposed on the basis of UV-vis and IR spectrophotometry, and four-point probe conductivity measurements.
Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors (2002)

Advanced colorectal cancers are often associated with elevated amounts of hyaluronan. To investigate the importance of hyaluronan in colon carcinoma tumor progression, we have expressed by stable transfection hyaluronan synthase 2 (Has2) and hyaluronidase 1 (Hyal1) in the rat colon carcinoma cell line, PROb. We found that hyaluronan overproduction led to a higher growth rate of tumor cells in vitro, and to a faster development of transplantable tumors in syngeneic rats, compared to the mock-transfectants. Has2 transfected PROb cells gave rise to tumors that were significantly less vascularized, but had a significantly larger viable tumor fraction compared to tumors generated from mock-transfectants. In contrast, Hyal1 overexpression suppressed the growth rate of tumor cells both in vitro and in vivo. Moreover, tumors derived from Hyal1-transfected cells had a significantly larger necrotic area than tumors derived from mock- and Has2-transfectants. Our study demonstrates that Has2 overproduction promotes tumorigenicity, whereas Hyal1 overexpression suppresses tumorigenicity in an experimental model for colon carcinoma.
Cost analysis of CO2 capture by antisublimation applied for coal fired boilers. (2007)

International audience
Nomenclature for renal replacement therapy in acute kidney injury: basic principles (2019)

Abstract This article reports the conclusions of a consensus expert conference on the basic principles and nomenclature of renal replacement therapy (RRT) currently utilized to manage acute kidney injury (AKI). This multidisciplinary consensus conference discusses common definitions, components, techniques, and operations of the machines and platforms used to deliver extracorporeal therapies, utilizing a “machine-centric” rather than a “patient-centric” approach. We provide a detailed description of the performance characteristics of membranes, filters, transmembrane transport of solutes and fluid, flows, and methods of measurement of delivered treatment, focusing on continuous renal replacement therapies (CRRT) which are utilized in the management of critically ill patients with AKI. This is a consensus report on nomenclature harmonization for principles of extracorporeal renal replacement therapies. Devices and operations are classified and defined in detail to serve as guidelines for future use of terminology in papers and research.
Data from <i>SETD2</i> Is Recurrently Mutated in Whole-Exome Sequenced Canine Osteosarcoma (2023)

&lt;div&gt;Abstract&lt;p&gt;Osteosarcoma is a debilitating bone cancer that affects humans, especially children and adolescents. A homologous form of osteosarcoma spontaneously occurs in dogs, and its differential incidence observed across breeds allows for the investigation of tumor mutations in the context of multiple genetic backgrounds. Using whole-exome sequencing and dogs from three susceptible breeds (22 golden retrievers, 21 Rottweilers, and 23 greyhounds), we found that osteosarcoma tumors show a high frequency of somatic copy-number alterations (SCNA), affecting key oncogenes and tumor-suppressor genes. The across-breed results are similar to what has been observed for human osteosarcoma, but the disease frequency and somatic mutation counts vary in the three breeds. For all breeds, three mutational signatures (one of which has not been previously reported) and 11 significantly mutated genes were identified. &lt;i&gt;TP53&lt;/i&gt; was the most frequently altered gene (83% of dogs have either mutations or SCNA in &lt;i&gt;TP53&lt;/i&gt;), recapitulating observations in human osteosarcoma. The second most frequently mutated gene, histone methyltransferase &lt;i&gt;SETD2&lt;/i&gt;, has known roles in multiple cancers, but has not previously been strongly implicated in osteosarcoma. This study points to the likely importance of histone modifications in osteosarcoma and highlights the strong genetic similarities between human and dog osteosarcoma, suggesting that canine osteosarcoma may serve as an excellent model for developing treatment strategies in both species.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Significance:&lt;/b&gt; Canine osteosarcoma genomics identify SETD2 as a possible oncogenic driver of osteosarcoma, and findings establish the canine model as a useful comparative model for the corresponding human disease. &lt;i&gt;Cancer Res; 78(13); 3421–31. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
No Further Fast Reroute (2000)

There are several cases where, once Fast Reroute has taken place (for
MPLS protection), a second fast reroute is undesirable, even
detrimental. This memo gives several examples of this, and proposes a
mechanism to prevent further fast reroutes.
Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 2:  Synthesis of Fragments C1-6 and C9-14 (2003)

Kilogram-scale syntheses of fragments C1-6 (6) and C9-14 (4) of (+)-discodermolide from common precursor 3 are described. Improved procedures for each step of both fragments were developed by minimizing or eliminating the formation of byproducts that were isolated and characterized in Smith's synthesis.
Factors influencing survival in patients undergoing palliative bypass for pancreatic adenocarcinoma (2012)

In a cohort of patients undergoing a palliative bypass procedure, specific peri-operative factors can be used to identify patients who are at risk of early mortality. These factors may be helpful in selecting appropriate interventions for this group of patients.
A VLSI data compression chip for high-speed image compression (2002)

A VLSI chip has been designed to perform a high-speed pyramid data compression algorithm for image processing. The algorithm implemented in the VLSI chip requires dramatically less computations yet it is an effective technique to perform the data compression. The computational complexity of the algorithm is at least 10 times less than that of the standard algorithm, JPEG while offering comparable performances in image quality to JPEG. Moreover, due to the simplified computational algorithm, the hardware complexity will be 3 to 4 times less than the VLSI chips based on JPEG, thus the cost/performance of the proposed VLSI data compression chip will be 30 to 40 times cheaper than any existing standard data compression chip.
Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy (2022)

Summary TDP-43 mediates proper Stathmin-2 (STMN2) mRNA splicing, and STMN2 protein is reduced in the spinal cord of most ALS patients. To test the hypothesis that STMN2 loss contributes to ALS pathogenesis, we generated constitutive and conditional STMN2 knockout mice. Constitutive STMN2 loss results in early-onset sensory and motor neuropathy featuring impaired motor behavior and dramatic distal neuromuscular junction (NMJ) denervation of fast-fatigable motor units, which are selectively vulnerable in ALS, without axon or motoneuron degeneration. Selective excision of STMN2 in motoneurons leads to similar NMJ pathology. STMN2 KO heterozygous mice, which better model the partial loss of STMN2 protein found in ALS patients, display a slowly progressive, motor-selective neuropathy with functional deficits and NMJ denervation. Thus, our findings strongly support the hypothesis that STMN2 reduction due to TDP-43 pathology contributes to ALS pathogenesis.
A general and efficient algorithm for &#x201C;top&#x201D; queries (2008)

"Top K" queries reduce a query result to the most interesting or the most urgent items. In many cases, e.g., when the result size is unbounded due to duplicate key values, a "top" operation cannot be implemented using the standard algorithm based on an in-memory priority queue. The default alternative is a full sort. External merge sort admits multiple novel optimizations specific to "top" operations. These are simple to implement yet greatly reduce the data volume written to runs on temporary storage. Experiments demonstrate substantial performance improvements, in one case exceeding three orders of magnitude.
Logical Abstract Interpretation (2017)

Interpretation over Combined Domain: Example 1·i, N(x)=N(y)+i struct List { struct List* next; } x, y; N(z) = 0, if z = null = 1 + N(z→next) y≠null y := x; i := 0; i := i+1; y := y→next; y=x, i=0 y=x→next i=1, x≠null N(x)=N(x→next 1 ⊥
Supplementary Table 3 from Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules (2023)

&lt;p&gt;Supplementary Table 3&lt;/p&gt;
Bifunctional covalent organic frameworks with two dimensional organocatalytic micropores (2014)

We report the successful incorporation of bifunctional (acid/base) catalytic sites in the crystalline organocatalytic porous COF (2,3-DhaTph). Due to the presence of acidic (catachol) and basic (porphyrin) sites, 2,3-DhaTph shows significant selectivity, reusability, and excellent ability to perform the cascade reaction.
Building the WorldWide Telescope (2008)

This paper is talks about the critical role that Jim Gray played in the creation of the WorldWide Telescope software. Contrary to what you might think it wasn't his database brilliance that made it happen, it was his generosity in sharing credit, inspiring, nurturing and connecting people, in this case that made it possible for the pieces to come into place and make it happen. Without Jim Gray's work with Alex Szalay on Sky Server and their ongoing support and encouragement, the software that is named in their honor would not exist today.
Impacts of Interleukin-17 Neutralization on the Inflammatory Response in a Healing Ligament (2017)

In this study, we sought to improve ligament healing by modulating the inflammatory response after acute injury through the neutralization of Interleukin-17 (IL-17), which we hypothesized would decrease inflammatory cell infiltration and cytokine production. Administration of an Interleukin-17 neutralizing antibody (IL-17 NA) immediately following a rat medial collateral ligament (MCL) transection resulted in alterations in inflammatory cell populations and cytokine expression within the healing ligament, but did not reduce inflammation. Specifically, treatment resulted in a decrease in M2 (anti-inflammatory) macrophages, an increase in T cells, and an increase in the levels of IL-2, IL-6, and IL-12 in the MCL 7 days post injury. IL-17NA treatment, and subsequent immunomodulation, did not result in improved ligament healing, as measured by collagen composition and wound size.
Standardization of bleeding assessment in immune thrombocytopenia: report from the International Working Group (2013)

In a previous publication on new terminology, definitions, and outcome criteria for immune thrombocytopenia (ITP), the International Working Group (IWG) on ITP acknowledged that response to treatment should consist of clinically meaningful end points such as bleeding manifestations and that platelet count may not be the ideal parameter for capturing the benefits of therapy. The IWG now proposes a consensus-based ITP-specific bleeding assessment tool (ITP-BAT) with definitions and terminology consistent with those adopted for other bleeding disorders. Bleeding manifestations were grouped into three major domains: skin (S), visible mucosae (M), and organs (O), with gradation of severity (SMOG). Each bleeding manifestation is assessed at the time of examination. Severity is graded from 0 to 3 or 4, with grade 5 for any fatal bleeding. Bleeding reported by the patient without medical documentation is graded 1. Within each domain, the same grade is assigned to bleeding manifestations of similar clinical impact. The "worst bleeding manifestation since the last visit" (observation period) is graded (a suitable database collection form is provided), and the highest grade within each domain is recorded. The SMOG system provides a consistent description of the bleeding phenotype in ITP, and the IWG unanimously supports its adoption and validation in future clinical studies.
Highly-Scalable Reconfigurable Computing (2005)

Reconfigurable computing, typically deployed using Field-Programmable Gate Arrays (FPGAs), is a technology that is ideally suited to exploit the fine-grained parallelism that exists in many algorithms and applications. SGI is a manufacturer of large-scale, high-performance computer systems and has recently developed an FPGA-based node that is integrated into its interconnect architecture. Exegy has deployed several codesigned applications onto commodity hardware (processors and FPGAs). Here, we describe our experience deploying Exegy applications on SGI systems, including both the application development process as well as performance results.
PEGylation of Concanavalin A to Improve Its Stability for anIn VivoGlucose Sensing Assay (2014)

Competitive binding assays utilizing concanavalin A (ConA) have the potential to be the basis of improved continuous glucose monitoring devices. However, the efficacy and lifetime of these assays have been limited, in part, by ConA's instability due to its thermal denaturation in the physiological environment (37 °C, pH 7.4, 0.15 M NaCl) and its electrostatic interaction with charged molecules or surfaces. These undesirable interactions change the constitution of the assay and the kinetics of its behavior over time, resulting in an unstable glucose response. In this work, poly(ethylene glycol) (PEG) chains are covalently attached to lysine groups on the surface of ConA (i.e., PEGylation) in an attempt to improve its stability in these environments. Dynamic light scattering measurements indicate that PEGylation significantly improved ConA's thermal stability at 37 °C, remaining stable for at least 30 days. Furthermore, after PEGylation, ConA's binding affinity to the fluorescent competing ligand previously designed for the assay was not significantly affected and remained at ~5.4 × 10(6) M(-1) even after incubation at 37 °C for 30 days. Moreover, PEGylated ConA maintained the ability to track glucose concentrations when implemented within a competitive binding assay system. Finally, PEGylation showed a reduction in electrostatic-induced aggregation of ConA with poly(allylamine), a positively charged polymer, by shielding ConA's charges. These results indicate that PEGylated ConA can overcome the instability issues from thermal denaturation and nonspecific electrostatic binding while maintaining the required sugar-binding characteristics. Therefore, the PEGylation of ConA can overcome major hurdles for ConA-based glucose sensing assays to be used for long-term continuous monitoring applications in vivo.
Transverse rotating waves in the non-linear optical system with spatial and temporal delay (2021)

A spatially distributed dynamic system with large-scale spatial and temporal interactions has been investigated. The model of the system is a non-linear optical ring resonator with field rotation around the optical axis and signal time delay in the feedback circuit. The parameters of large-scale spatio-temporal interactions determine the characteristics of the non-linear rotatory modes.
83‐1L: Late‐News Paper : Electro‐optic Characteristics of OZ‐IPS LCD Utilizing an Application‐Type, Zero‐Azimuth Anchoring Material (2017)

In this study, a one‐side zero‐anchoring in‐plane switching (OZ‐IPS) liquid crystal display that used an application‐type, zero‐azimuth anchoring material as a substitute for polymer brushes was successfully developed. The transmission efficiency of this OZ‐IPS cell was also improved by optimizing its optical design.
Surface segregation of Ag in CdTe induced by photon absorption (1984)

The first observation of a new impurity segregation or gettering phenomenon has been demonstrated in CdTe using radioactive Ag. Noble metal dopant impurities have been found to segregate to the surface region of CdTe during exposure to ambient light. This phenomenon occurs while the sample is held at room temperature and is not induced by localized heating or surface chemical reactions. Experimental results suggest that a redistribution of excess carriers produced by photon absorption near the CdTe surface may be responsible for the behavior.