gebhart/patrepeval huggingface dataset:
An RPC Mechanism for Transportable Agents (1996)

Transportable agents are autonomous programs that migrate from machine to machine, performing complex processing at each step to satisfy client requests. As part of their duties agents often need to communicate with other agents. We propose to use remote procedure call (RPC) along with a flexible interface definition language (IDL), to add structure to inter-agent communication. The real power of our Agent RPC comes from a client-server binding mechanism based on flexible IDL matching and from support for multiple simultaneous bindings. Our agents are programmed in Agent Tcl; we describe how the Tcl implementation made RPC particularly easy to implement. Finally, although our RPC is designed for Agent Tcl programs, the concepts would also work for standard Tcl programs. Keywords - Transportable Agents, Remote Procedure Call (RPC), Interprocess Communication. This work was funded in part by Office of Naval Research (ONR) contract number N00014-95-1-1204. Their support is gratefully ack...
Autoimmune polyendocrine syndrome type 1: Utility of KCNRG autoantibodies as a marker of active pulmonary disease and successful treatment with rituximab (2011)

Autoimmune polyendocrine syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy Candidiasis and Ectodermal Dysplasia (APECD) is a disorder caused by mutations in the autoimmune regulator (AIRE) gene. In some APS-1 patients, significant pulmonary disease is observed. Autoantibodies directed against the potassium channel regulatory protein (KCNRG), found in epithelial cells of terminal bronchioles, have been suggested as a marker for pulmonary disease in APS-1 patients. We report two patients with APS-1; one with and one without lung disease. Patient 1 had multiple admissions for pneumonia and respiratory insufficiency, required non-invasive ventilation, and had findings of bronchiectasis on thoracic imaging and significant lymphocytic infiltrates of the airways on lung biopsy. To verify the autoimmune cause of pulmonary symptoms APS-1 patients, both were tested in a blinded manner for the presence of autoantibodies to KCNRG in serum. We found that only Patient 1 had autoantibodies present. Additionally, Patient 1 had progressive disease despite treatment with several immunomodulating agents, including corticosteroids, azathioprine, and mycophenolate. Patient 1 had a lung biopsy performed which was consistent with B cell lymphocytic aggregates. Rituximab treatment was initiated with apparent good response. This report illustrates the practical use of KCNRG autoantibodies to identify APS-1 patients with pulmonary risk and the successful use of the monoclonal antibody, Rituximab, to treat pulmonary disease in APS-1 patients.
Limbic System Interrelations: Functional Division Among Hippocampal-Septal Connections (1977)

Neuronal activity was recorded simultaneously from hippocampus and medical or lateral septum during classical conditioning of the rabbit nictitating membrane response. Although similarities exist between hippocampal and lateral septal patterns of activity, medial septal unit discharges indicate a different role during learning.
Shadow Detection for Ultrasound Images Using Unlabeled Data and Synthetic Shadows (2019)

Medical ultrasound is widely used technique for diagnosing internal organs. As common artifacts, shadows often appear in ultrasound images. Detecting such shadows is curious because they prevent accurate diagnosis. In this paper, we propose a novel shadow detection method based on auto-encoding structure. It once separates an input image into a shadow image and a content image using two decoders and combines them to reconstruct the input. To lead the network into separating the input, we inject synthetic shadows into the input and make the network to predict them as the shadow image. Since we know the rough shape of shadows as basic domain knowledge, we can generate plausible shadows. These processes are achieved by using only unlabeled data. Experiments on ultrasound images for fetal heart diagnosis shows the effectiveness of the method.
Genetic and biochemical normalization in female carriers of Duchenne muscular dystrophy (1995)

We studied 19 symptomatic female carriers of the Duchenne muscular dystrophy (DMD) gene. Most of these dystrophinopathy patients had had an erroneous or ambiguous diagnosis prior to dystrophin immunofluorescence testing. We assessed clinical severity by a standardized protocol, measured X-chromosome inactivation patterns in blood and muscle DNA, and quantitated the dystrophin protein content of muscle. We found that patients could be separated into two groups: those showing equal numbers of normal and mutant dystrophin genes in peripheral blood DNA ("random" X-inactivation), and those showing preferential use of the mutant dystrophin gene ("skewed" X-inactivation). In the random X-inactivation carriers, the clinical phenotype ranged from asymptomatic to mild disability, the dystrophin content of muscle was > 60% of normal, and there were only minor histopathologic changes. In the skewed X-inactivation patients, clinical manifestations ranged from mild to severe, but the patients with mild disease were young (5 to 10 years old). The low levels of dystrophin (< 30% on average) and the severe symptoms of the older patients suggested a poor prognosis for those with skewed X-inactivation, and they all showed morphologic changes of dystrophy. The random inactivation patients showed evidence of biochemical "normalization," with higher dystrophin content in muscle than predicted by the number of normal dystrophin genes. Seventy-nine percent of skewed X-inactivation patients (11/14) showed genetic "normalization," with proportionally more dystrophin-positive nuclei in muscle than in blood. In 65% of the skewed X-inactivation patients, dystrophin was not produced by dystrophin-positive nuclei; an average of 20% of myofiber nuclei were genetically dystrophin-positive but did not produce stable dystrophin. Biochemical normalization seems to be the main mechanism for rescue of fibers from dystrophin deficiency in the random X-inactivation patients. In the skewed X-inactivation patients, genetic normalization is active, but production failure of dystrophin by dystrophin-normal nuclei may counteract any effect of biochemical normalization. In the skewed X-inactivation patients, the remodeling of the muscle through cycles of degeneration and regeneration led to threefold increase in the number of dystrophin-competent nuclei in muscle myofibers (3.3 +/- 4.6), while dystrophin content was on the average 1.5-fold less then expected (-1.54 +/- 3.38). Our results permit more accurate prognistic assessment of isolated female dystrophinopathy patients and provide important data with which to estimate the potential effect of gene delivery (gene therapy) in DMD.
Low-Density Attack Revisited. (2007)

The low-density attack proposed by Lagarias and Odlyzko is a powerful algorithm against the subset sum problem. The improvement algorithm due to Coster et al. would solve almost all the problems of density &amp;lt; 0.9408... in the asymptotical sense. On the other hand, the subset sum problem itself is known as an NP-hard problem, and a lot of efforts have been paid to establish public-key cryptosystems based on the problem. In these cryptosystems, densities of the subset sum problems should be higher than 0.9408... in order to avoid the low-density attack. For example, the Chor-Rivest cryptosystem adopted subset sum problems with relatively high densities. In this paper, we further improve the low-density attack by incorporating an idea that integral lattice points can be covered with polynomially many spheres of shorter radius and of lower dimension. As a result, the success probability of our attack can be higher than that of Coster et al.’s attack for fixed dimensions. The density bound is also improved for fixed dimensions. Moreover, we numerically show that our improved low-density attack makes the success probability higher in case of low Hamming weight solution, such as the Chor-Rivest cryptosystem, if we assume SVP oracle calls.
A 20-mA quiescent current two-stage W-CDMA power amplifier using anti-phase intermodulation distortion (2004)

This paper explains how the adjacent-channel-leakage-power ratio (ACLR) of power amplifiers (PAs) can be reduced by using gain-expansion amplifiers in tandem and generating anti-phase intermodulation distortion (IMD) in the driver stage to cancel the IMD in the output stage. The power-added-efficiency (PAE) can thus be increased by using near-class-B-biased driver- and output-stage amplifiers, which inherently have gain-expansion characteristics and high PAE at low output power as well as at maximum output power. At a supply of 3.5 V and an output power of 27.1 dBm, the fabricated PA with a quiescent current of only 19.8 mA exhibited a PAE of 44%, a gain of 25.2 dB, and an ACLR of less than -38.0 dBc. This is state-of-the-art performance for a two-stage W-CDMA PA with an extremely low quiescent current.
Myelin repair stimulated by CNS-selective thyroid hormone action (2019)

Oligodendrocyte processes wrap axons to form neuroprotective myelin sheaths, and damage to myelin in disorders, such as multiple sclerosis (MS), leads to neurodegeneration and disability. There are currently no approved treatments for MS that stimulate myelin repair. During development, thyroid hormone (TH) promotes myelination through enhancing oligodendrocyte differentiation; however, TH itself is unsuitable as a remyelination therapy due to adverse systemic effects. This problem is overcome with selective TH agonists, sobetirome and a CNS-selective prodrug of sobetirome called Sob-AM2. We show here that TH and sobetirome stimulated remyelination in standard gliotoxin models of demyelination. We then utilized a genetic mouse model of demyelination and remyelination, in which we employed motor function tests, histology, and MRI to demonstrate that chronic treatment with sobetirome or Sob-AM2 leads to significant improvement in both clinical signs and remyelination. In contrast, chronic treatment with TH in this model inhibited the endogenous myelin repair and exacerbated disease. These results support the clinical investigation of selective CNS-penetrating TH agonists, but not TH, for myelin repair.
What Will 5G Be (2014)

What will 5G be? What it will not be is an incremental advance on 4G. The previous four generations of cellular technology have each been a major paradigm shift that has broken backwards compatibility. And indeed, 5G will need to be a paradigm shift that includes very high carrier frequencies with massive bandwidths, extreme base station and device densities and unprecedented numbers of antennas. But unlike the previous four generations, it will also be highly integrative: tying any new 5G air interface and spectrum together with LTE and WiFi to provide universal high-rate coverage and a seamless user experience. To support this, the core network will also have to reach unprecedented levels of flexibility and intelligence, spectrum regulation will need to be rethought and improved, and energy and cost efficiencies will become even more critical considerations. This paper discusses all of these topics, identifying key challenges for future research and preliminary 5G standardization activities, while providing a comprehensive overview of the current literature, and in particular of the papers appearing in this special issue.
Core–Shell Gold Nanorod@Zirconium-Based Metal–Organic Framework Composites as in Situ Size-Selective Raman Probes (2019)

Nanoparticle encapsulation inside zirconium-based metal-organic frameworks (NP@MOF) is hard to control, and the resulting materials often have nonuniform morphologies with NPs on the external surface of MOFs and NP aggregates inside the MOFs. In this work, we report the controlled encapsulation of gold nanorods (AuNRs) by a scu-topology Zr-MOF, via a room-temperature MOF assembly. This is achieved by functionalizing the AuNRs with poly(ethylene glycol) surface ligands, allowing them to retain colloidal stability in the precursor solution and to seed the MOF growth. Using this approach, we achieve core-shell yields exceeding 99%, tuning the MOF particle size via the solution concentration of AuNRs. The functionality of AuNR@MOFs is demonstrated by using the AuNRs as embedded probes for selective surface-enhanced Raman spectroscopy (SERS). The AuNR@MOFs are able to both take-up or block molecules from the pores, thereby facilitating highly selective sensing at the AuNR ends. This proof-of-principle study serves to present both the outstanding level of control in the synthesis and the high potential for AuNR@Zr-MOF composites for SERS.
WETICE 2009 First Workshop on Collaboration and Cloud Computing (2009)

Bandwidth inversion (network bandwidth becoming larger than computer internal bus bandwidth), Virtualization of computing, network and storage resources and web based service development environments are changing the way the services are developed and delivered over the Internet. Virtualization allows computing (CPU and memory), storage (capacity, storage I/O, storage throughput) and bandwidth to be shared among multiple service developers, and service delivery applications supporting both end customers (consumer market) and businesses (both small and medium enterprises). This is expected to provide massive scales of economy through consolidation, improved resource utilization, and, avoid the need for the investments by individual businesses to meet peak workloads through over-provisioning. Analogies to utility model (i.e., providing resources that are ubiquitously available, massively scalable, on-demand, pay-per-use and managed) are often invoked to compare network based access of computing and storage resources (often called the cloud) to telecommunications network or power grid. The lower affinity that the virtualization technologies provide between applications and the resources makes it possible to dynamically switch the resources based on their latency constraints and resource utilization profiles.
Evaluation of Intracerebral Grafting of Dopamine-Secreting PC12 Cells into Allogeneic and Xenogeneic Brain (1997)

The PC12 pheochromocytoma tumor cell line is derived from a rat adrenal medullary tumor and secretes dopamine. We have previously reported that grafted microencapsulated PC12 cells using agarose and poly(styrene sulfonic acid) survived in the xenogeneic brain without immunosuppression. To investigate whether unencapsulated PC12 cells form a tumor and how they provoke immunological reaction, PC12 cell suspension was implanted into the striatum of Sprague-Dawley rat (allogeneic graft) or guinea pig (xenogeneic graft) and histological analysis using Nissl stain and immunocytochemical analysis using antityrosine hydroxylase (TH) antibody were performed 1, 2, and 4 wk after transplantation. Host animals were not immunosuppressed. PC12 cells formed a mass 1 and 2 wk after transplantation both in allogeneic and xenogeneic brain. These grafted PC12 cells were immunoreactive to anti-TH antibody. Four weeks after transplantation, however, grafted PC12 cells in the allogeneic brain were only found within the restricted area near the site of implantation. In the xenogeneic brain, only the trace of grafted PC12 cells were found around the site of implantation 4 wk after transplantation. In both allogeneic and xenogeneic animals, a number of lymphocytes were found in and around the grafts at all period investigated. These findings indicate that PC12 cells could survive in the allogeneic or xenogeneic brain for 2 wk and were ultimately rejected by immunological reaction by 4 wk after transplantation. Implantation of encapsulated PC12 cells in the allogeneic or xenogeneic brain is considered a safe and effective method for delivering dopamine into the brain because PC12 cells will not form a tumor in the long-term even if capsules are damaged in some reason.
<title>New results on surface flashover in silicon-dielectric systems</title> (1993)

New experimental results are reported for silicon samples at high fields in different ambients: vacuum, N<SUB>2</SUB>, air, SF<SUB>6</SUB> and SF<SUB>6</SUB> + N<SUB>2</SUB> mixtures, for different experimental conditions. The strong influence of the semiconductor quality and ambient dielectric on the prebreakdown and breakdown response of the system is presented. The high surface flashover sensitivity of semiconductor-vacuum system, as well as the significant interface activity in air and N<SUB>2</SUB> is explained. Using a new physical model of the breakdown in semiconductor- dielectric systems, a new technique was developed consisting of an in-situ treatment of the semiconductor sample (in vacuum) before performing the high field measurements in SF<SUB>6</SUB>. Dramatic improvement of the voltage hold-off was obtained in one atmosphere (absolute) SF<SUB>6</SUB>. All standard good quality samples, subjected to the vacuum pre-treatment, supported without surface flashover, high fields in the range of 75 - 85 kV/cm, close to the critical breakdown field for SF<SUB>6</SUB> gas at one atmosphere (approximately 89 kV/cm). The role of different defects in producing premature breakdown by surface flashover in SF<SUB>6</SUB> is discussed.
Fuel Efficiency Estimates for Future Light Duty Vehicles, Part A: Engine Technology and Efficiency (2016)

<div class="section abstract"><div class="htmlview paragraph">This study evaluates powertrain technologies capable of reducing light duty vehicle fuel consumption for compliance with 2025 CAFE standards. A fully integrated GT-Power engine model with physics based sub-models was developed to capture any positive or negative synergies between the technologies. The two zone multi-cylinder engine model included typical thermodynamic subroutines, with predictive combustion, flame quench and knock models, along with map-based turbocharger models to capture key combustion and efficiency behaviors. The engine model was calibrated to data from a boosted GDI engine and exercised through one series of current and production viable technology configurations for 2025 regulations. Technologies evaluated included: dual cam phasing and discrete variable valve lift to reduce pumping work, engine friction reduction via improved lubrication, gasoline direct injection, downsized and boosted operation to reduce the relative contributions of friction and pumping losses, and the introduction of cooled EGR to mitigate knock. The results showed that the valvetrain improvements reduced pumping work and widened the low BSFC islands without impacting peak efficiency. While downsizing and boosting provided little fuel economy benefit at a constant BMEP, it provides a benefit at constant engine torque by shifting operation to higher BMEPs with improved efficiency. The introduction of cooled EGR improved efficiency slightly at constant BMEP. The impact of these engine efficiency improvements on the resulting vehicle fuel economy is studied in a companion paper.</div></div>
A goal model elaboration for localizing changes in software evolution (2013)

Software evolution is an essential activity that adapts existing software to changes in requirements. Localizing the impact of changes is one of the most efficient strategies for successful evolution. We exploit requirements descriptions in order to extract loosely coupled components and localize changes for evolution. We define a process of elaboration for the goal model that extracts a set of control loops from the requirements descriptions as components that constitute extensible systems. We regard control loops to be independent components that prevent the impact of a change from spreading outside them. To support the elaboration, we introduce two patterns: one to extract control loops from the goal model and another to detect possible conflicts between control loops. We experimentally evaluated our approach in two types of software development and the results demonstrate that our elaboration technique helps us to analyze the impact of changes in the source code and prevent the complexity of the code from increasing.
Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities (2021)

Human induced pluripotent stem cells (hiPSCs) can generate a multiplicity of organoids, yet no compelling evidence currently exists as to whether or not these contain tissue-specific, holoclone-forming stem cells. Here, we show that a subpopulation of cells in a hiPSC-derived corneal epithelial cell sheet is positive for ABCB5 (ATP-binding cassette, sub-family B, member 5), a functional marker of adult corneal epithelial stem cells. These cells possess remarkable holoclone-forming capabilities, which can be suppressed by an antibody-mediated ABCB5 blockade. The cell sheets are generated from ABCB5<sup>+</sup> hiPSCs that first emerge in 2D eye-like organoids around six weeks of differentiation and display corneal epithelial immunostaining characteristics and gene expression patterns, including sustained expression of ABCB5. The findings highlight the translational potential of ABCB5-enriched, hiPSC-derived corneal epithelial cell sheets to recover vision in stem cell-deficient human eyes and represent the first report of holoclone-forming stem cells being directly identified in an hiPSC-derived organoid.
Computed Tomography Analysis of Third Webspace Injections for Interdigital Neuroma (2013)

Steroid injections for interdigital neuroma were accurate for therapeutic purposes but not diagnostic, except potentially for distinguishing webspace pain from joint pain.
Reduction of Aspect Ratio in 650 nm-Band Self-Sustained-Pulsing Lasers with Saturable-Absorbing Layer (1997)

650 nm-band self-pulsing lasers which exhibit an extremely low laser beam profile aspect ratio (2.6) and a small astigmatism (2 µm) were successfully demonstrated by optimizing the design of the layer structure. Low-noise self-pulsing lasers have been developed as a light source for optical disc systems. In the case of mounting the lasers on optical systems, a low aspect ratio and a small astigmatism are required in order to realize high optical coupling efficiency and good optical focusing characteristics. In this paper, we report a reduction of the aspect ratio while maintaining a small astigmatism in self-pulsing AlGaInP lasers with a saturable absorbing (SA) layer by optimizing the optical confinement and compressive strain in the SA layer. Simultaneously, a very low intensity noise characteristic up to 50° C was confirmed by stable self-sustained pulsation characteristics.
Identifying Splitting Through Sentiment Analysis (2023)

In Kernerg's Object Relations Theory model of personality pathology, splitting, the mutual polarization of aspects of experience, is thought to result in a failure of identity integration. The authors sought to identify a clinician-independent, automated measure of splitting by examining 54 subjects' natural speech. Splitting in these individuals, recruited from the community, was investigated and evaluated with a shortened version of the Structured Interview of Personality Organization (STIPO-R). A type of automated sentiment textual analysis called VADER was applied to transcripts from the section of the STIPO-R that probes identity integration. Higher variability in speech valence, more negative minimum valence, and more frequent shifts in valence polarity were associated with more severe identity disturbance. The authors concluded that the degree of splitting elicited during the description of self and others is related to the degree of identity disturbance, and to the degree of negativity and instability of these descriptions of self and others.