gebhart/patrepeval huggingface dataset:
Aspectos inmunopatológicos de la retinopatía diabética proliferativa (1992)

espanolUltimamente, se ha dedicado un especial interes en la investigacion de los mecanismos inmunogenicos que parecen estar implicados en la proliferacion celular en las formas mas graves de retinopatia diabetica. En este estudio, tratamos de identificar las alteraciones inmunopatologicas a nivel de los constituyentes celulares de 16 membranas neovasculares diabeticas, obtenidas en la cirugia vitreoretiniana, en aquellos casos de retinopatia diabetica proliferativa. Los resultados muestran la expresion de antigenos de la Clase ll del Complejo Mayor de Histocompatibilidad (HLA-DR) en las celulas de membranas neovascularizadas en la retinopatia diabetica proliferativa. La presencia de los antigenos de la Clase ll sugiere que esta expresion puede ser inducida en las celulas oculares durante el desarrollo de respuestas inmunes o autoinmunes locales. La presencia de fibronectina y celulas inmunocompetentes (linfocitos T y macrofagos activados) refuerza la hipotesis de que un proceso mediado inmunologicamente mantendria las actividades proliferativas de las membranas neovasculares. Estos fenomenos inmunitarios podrian funcionar como un verdadero sistema de amplificacion local provocado por factores de crecimiento liberados por una agresion en la retina, conduciendo a un proceso proliferativo, extenso y destructivo, que se autoperpetua. EnglishLately, a special interest has been dedicated in the investigation of the immunogenics mechanisms that seems implicated in the cellular proliferation of the most serious forms of the diabetic retinopathy. In this study, we try to identify the immunopathologic alterations in the level of the cellular constituents of 16 diabetic neovascular membranes obtain in the vitreous-retinal surgery, in those cases of proliferative diabetic retinopathy. The results shows the expression of antigen of Class 11 of the Big Complex of Histocompatibility (HLA-DR) in the cells of neovascularizated membranes in the proliferative diabetic retinopathy. The presence of antigens of Class 11 suggest that this expression can be induced in ocular cells during the developing of immunes answers or local autoimmunes. The presence of fibronectin and immunocompetents cells (T Iymphocytes and activated macrophage) reinforcement the hypothesis that a immunologicament medium process maintain the proliferatives activities of the neovascular membranes. This immunitary phenomenos would be able to work as a real system of local arnplification provocated by growing factors release by an aggression in the retina, leading to a proliferative process, wide and destructive, that auto-perpetual itself.
Temperature‐Dependent Crystal Structures of Ti 2 AlN and Cr 2 GeC as Determined from High Temperature Neutron Diffraction (2011)

In this work, we report on the temperature‐dependent crystal structures of the isostructural, layered hexagonal phases Ti 2 AlN and Cr 2 GeC determined by Rietveld analysis of high temperature neutron powder diffraction data of fully dense, polycrystalline, bulk samples in the 100° to 1100°C temperature range. For both phases, the A‐group atoms, Al and Ge, vibrate with the highest amplitude and do so anisotropically within the basal plane. All bonds expand linearly with temperature, with the highest relative thermal expansion occurring in the Ti–Al and Cr–Ge bonds. The thermal expansion coefficients in the a ‐ and c ‐direction are, respectively, 10.3(±0.2) × 10 −6 and 9.3(±0.2) × 10 −6 K −1 for Ti 2 AlN and 12.8(±0.3) × 10 −6 and 14.6(±0.3) × 10 −6 K −1 for Cr 2 GeC . The unit cell volume expansions observed by HTND are 10.0(±0.2) × 10 −6 K −1 for Ti 2 AlN and 13.4(±0.3) × 10 −6 K −1 for Cr 2 GeC.
Backward Wave Oscillator Development at 300 and 650 GHz (2006)

A 300 GHz backward wave oscillator (BWO) is presently in fabrication and the design of a 650 GHz BWO is nearing completion. Both devices make use of the novel biplanar interdigital slow wave circuit and patented GENVAC technology for the fabrication of intricate chemical vapor deposition (CVD) diamond structures
ChemInform Abstract: A Highly Active Catalyst for Pd‐Catalyzed Amination Reactions: Cross‐Coupling Reactions Using Aryl Mesylates and the Highly Selective Monoarylation of Primary Amines Using Aryl Chlorides. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Synthesis, redox behavior and spin-trap properties of 2,6-di-tert-butylnitrosobenzene (DTBN) (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, redox behavior and spin-trap properties of 2,6-di-tert-butylnitrosobenzene (DTBN)V. Cerri, C. Frejaville, F. Vila, A. Allouche, G. Gronchi, and P. TordoCite this: J. Org. Chem. 1989, 54, 6, 1447–1450Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/jo00267a041https://doi.org/10.1021/jo00267a041research-articleACS PublicationsRequest reuse permissionsArticle Views370Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes (1993)

Introduction of TCR alpha transgene, TCR beta transgene, or both into RAG-2-/-mice differentially rescues T cell development. RAG-2-/- mice have small numbers of TCR-CD4-CD8-(double negative, DN) thymocytes that express CD3 gamma delta epsilon and zeta proteins intracellularly. Introduction of a TCR beta transgene, but not a TCR alpha transgene, into the RAG-2-/- background restored normal numbers of thymocytes. These cells were CD4+CD8+ (double positive, DP) and expressed small amounts of surface TCR beta chain dimers in association with CD3 gamma delta epsilon but not zeta. RAG-2-/- mice that expressed alpha and beta TCR transgenes developed both DP and single positive thymocytes. Thus, the TCR beta subunit, possibly in association with a novel CD3 complex, participates in the DN to the DP transition.
Abstract 3894: Discovery, synthesis and SAR studies of a novel nonpeptidic reversible proteosome inhibitor with low nano-molar chymotrypsin like activity (2012)

Abstract The development of proteosome inhibitors for CT-L activity has been the subject of considerable interest in the treatment of cancer due to its critical role in maintaining homeostasis and hence its key position in many cellular processes. Proteosome inhibitors are classified as reversible or irreversible inhibitors according to their chemical structure and their mechanism of inhibition. Irreversible inhibitors possess a chemically reactive group, such as aldehydes, boronic acids, epoxy ketones that react with catalytic Thr1-O covalently, where as reversible inhibitors inhibit proteosome non-covalently via H-bond interactions (electrostatic and/or van der Waals). Bortezomib, a peptide boronic acid analog, is the first clinically approved proteosome inhibitor and is found to be an irreversible or slow reversible inhibitor that forms covalent bond with the N-terminal nucleophilic Thr1 in the β5 subunit of the proteasome. Reversible proteosome inhibitors (peptidic molecules) reported to date inhibit the proteosome non-covalently. Similar to Bortezomib, MLN9708 is a modified dipeptidyl boronic acid, which hydroylses immediately in plasma to MLN2238, is a potent, reversible and specific inhibitor of the chymotrypsin-like subunit of the proteasome. Small molecules as reversible proteosome inhibitors are less extensively investigated. In this study, we present the discovery of PI-184, non-peptidic small molecule with a pyridine and oxadiazole pharmacore as a reversible, potent and a novel proteasome inhibitor. Structure Activity relationship (SAR) guided synthesis of analogs around PI-184 led to the discovery of highly potent compounds with in-vivo chymotrypsin-like inhibitory activity. Here we present the detailed SAR, in-vitro and in-vivo proteasome activity of PI-184 class of compounds as potential anti-cancer agents. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3894. doi:1538-7445.AM2012-3894
Usage-Based Evolution of Visual Analysis Tools (2005)

Visual analysis tools have been developed to help people in many different domains more effectively explore, understand, and make decisions from their information. Challenges in making a successful tool include suitability within a user's work processes, and tradeoffs between analytic power and tool complexity, both of which impact ease of learning. This paper describes experience working with users to help them apply visual analysis tools in several different domains, and examples of how the tools evolved significantly to better match users' goals and processes.
A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol (2017)

Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. However, some healthy individuals have pre-existing anti-PEG antibodies and certain patients develop anti-PEG antibody during treatment with PEGylated medicines, suggesting that genetics might play a role in PEG immunogenicity. Here we perform genome-wide association studies for anti-PEG IgM and IgG responses in Han Chinese with 177 and 140 individuals, defined as positive for anti-PEG IgM and IgG responses, respectively, and with 492 subjects without either anti-PEG IgM or IgG as controls. We validate the association results in the replication cohort, consisting of 211 and 192 subjects with anti-PEG IgM and anti-PEG IgG, respectively, and 596 controls. We identify the immunoglobulin heavy chain (IGH) locus to be associated with anti-PEG IgM response at genome-wide significance (P = 2.23 × 10<sup>-22</sup>). Our findings may provide novel genetic markers for predicting the immunogenicity of PEG and efficacy of PEGylated therapeutics.Some individuals develop antibodies against the polyethylene glycol that is commonly used in therapeutic preparations. Here the authors conduct a GWAS in Han Chinese and find the IGH locus is associated with anti-PEG IgM.
Design and synthesis of conjugated materials for efficient optoelectronic devices (1999)

Highly luminescent poly(arylene vinylene)s can be prepared by a range of polycondensation methods. In this paper we report the synthesis of useful monomers and their application in the Gilch dehydrohalogenation and Wittig polycondensation methods to prepare highly luminescent poly(1,4-phenylene vinylene) (PPV) homo- and copolymers for use in light emitting devices.
Thyrointegrin αvβ3 nano targeted delivery of chemotherapy into solid tumors and its microenvironment. (2019)

e14661 Background: Cancer cells and rapidly dividing endothelial cells relevant to tumors primarily express the αvβ3 integrin. Conjugation of tetraiodothyroacetic acid (tetrac) as diamino-tetrac to a poly (lactic-co-glycolic acid) (PLGA) polymer for the formation of Nano DAT was used to target a specific cell surface receptor on the αvβ3 integrin. PLGA prohibits cell entry and the nano shell could be loaded with a generic cancer chemotherapeutic. Without a payload, Nano DAT has anticancer and anti-angiogenesis properties. Methods: Xenografts of human urinary bladder cancer (263JBV) cells, human breast cancer (SUM149PT) cells, and human pancreatic cancer (SUIT-2) cells were established. Tumor growth and tumor content of cisplatin (263JBV xenografts), doxorubicin (SUM149PT xenografts), or of paclitaxel (SUIT-2 xenografts) were compared in the following daily treatment animal arms of cohorts for 3 weeks: (1) controls, (2) void PLGA Nanoparticle (NPs), (3) chemotherapeutic agent (cisplatin 1 mg/kg, doxorubicin 1 mg/kg, or paclitaxel 0.3 mg/kg), (4) Nano DAT 0.3 mg/kg, and (5) chemotherapeutic agent encapsulated into PLGA NPs and into Nano DAT. Results: Tumors in animals treated with Nano DAT bearing a payload of cisplatin, paclitaxel, or doxorubicin were associated with decreased tumor weight by 50%-60% (P &lt; 0.01) with &gt; 90% loss of cancer cell viability. Mean chemotherapeutic agents content of tumors (ng/gm of tissue) was 5-fold that of tumors from animals treated with chemotherapy, alone, and 3-fold that of tumors exposed to chemotherapy encapsulated into PLGA NPs, measured with an established LC/MS/MS method. Animals receiving cisplatin, alone, developed neurotoxicity (inability to use the hind limbs) in comparison to an animal group treated with Nano DAT bearing a payload of cisplatin, and was confirmed histopathologically. Conclusions: The payload capacity of Nano DAT for cancer chemotherapeutic agents and tumor-specific delivery of cancer chemotherapeutic agents significantly increases bladder, breast and pancreatic cancer content of, respectively, cisplatin and paclitaxel.
Supplementary Figure 3G from Aberrant Silencing of Cancer-Related Genes by CpG Hypermethylation Occurs Independently of Their Spatial Organization in the Nucleus (2023)

Supplementary Figure 3G from Aberrant Silencing of Cancer-Related Genes by CpG Hypermethylation Occurs Independently of Their Spatial Organization in the Nucleus
Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers (2014)

Differences in associations of common BC susceptibility alleles between BRCA1 and BRCA2 carriers and the general population are explained to a large extent by differences in the prevalence of ER-positive and ER-negative tumors. Estimates of the risks associated with these variants based on population-based studies are likely to be applicable to mutation carriers after taking ER status into account, which has implications for risk prediction.
Cross sections for electron excitation of the2t3S metastable level of He into higher triplet levels (1997)

Cross sections for electron excitation out of the 2${\mathrm{}}^{3}$S metastable level of He into the 2${\mathrm{}}^{3}$P, 3${\mathrm{}}^{3}$S, 3${\mathrm{}}^{3}$P, 3${\mathrm{}}^{3}$D, 4${\mathrm{}}^{3}$S, 4${\mathrm{}}^{3}$P, 4${\mathrm{}}^{3}$D, 5${\mathrm{}}^{3}$S, and 5${\mathrm{}}^{3}$D levels have been obtained for energies up to 18 eV. We have observed a broad excitation function for the 2${\mathrm{}}^{3}$P level with a peak apparent cross section of 1.2\ifmmode\times\else\texttimes\fi{}${10}^{\mathrm{\ensuremath{-}}14}$${\mathrm{ncm}}^{2}$. For the n=3, 4, and 5 levels, the excitation functions show a pattern of sharp peaks for excitation into the n${\mathrm{}}^{3}$S levels, slightly less sharp peaks for excitation into the n${\mathrm{}}^{3}$P levels, and relatively broad peaks for excitation into the n${\mathrm{}}^{3}$D levels. Absolute cross sections have been obtained for all the above mentioned levels using a laser-induced fluorescence technique and the results agree well with experimental values reported by Lagus et al. [Phys. Rev. A 53, 1505 (1996)] The cross sections for the 2${\mathrm{}}^{3}$S\ensuremath{\rightarrow}n${\mathrm{}}^{3}$P excitations which correspond to dipole-allowed optical transitions are smaller than the corresponding 2${\mathrm{}}^{3}$S\ensuremath{\rightarrow}n${\mathrm{}}^{3}$S and 2${\mathrm{}}^{3}$S\ensuremath{\rightarrow}n${\mathrm{}}^{3}$D excitation cross sections, in contrast to the trends observed for excitations out of the ground level. This reversal behavior is discussed in terms of the dipole matrix element sum rule. Our cross-section data are compared with those of the alkali-metal atoms.
Roles of Coagulation and Fibrinolysis in Angiotensin II‐Enhanced Microvascular Thrombosis (2014)

These findings implicate a role for thrombin generation pathway in the accelerated thrombosis induced by AngII and suggest that an impaired protein C pathway and increased PAI-1 do not make a significant contribution to this model of microvascular thrombosis.
Designing for Maintainability, Failure Resilience, and Evolvability in Ubiquitous Computing Software (2002)

The design constraints in ubiquitous computing (ubicomp) differ from those traditionally emphasized by the systems community: evolvability, long-term maintainability, and robustness to transient failures are essential, while scalability and performance are lesser concerns, due to the nature of ubicomp itself and the performance of today&amp;apos;s commodity equipment. We show how these observations are reflected in the design of iROS, a ubicomp software framework in production use. In particular, we show that a centralized architecture directly enables the ubicomp programming abstractions needed while providing the best solution for evolvability and maintainability/deployability, and that we can achieve the required robustness through a fast-recovery strategy, which allows a simple centralized implementation of the architecture. Throughout, we achieve performance, scalability, and recovery behavior sufficient for typical operation.
Equivalent linearization for fatigue life estimates of a nonlinear structure (1989)

An analysis is presented of the suitability of the method of equivalent linearization for estimating the fatigue life of a nonlinear structure. Comparisons are made of the fatigue life of a nonlinear plate as predicted using conventional equivalent linearization and three other more accurate methods. The excitation of the plate is assumed to be Gaussian white noise and the plate response is modeled using a single resonant mode. The methods used for comparison consist of numerical simulation, a probabalistic formulation, and a modification of equivalent linearization which avoids the usual assumption that the response process is Gaussian. Remarkably close agreement is obtained between all four methods, even for cases where the response is significantly linear.
Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent N-acetylaspartate (2017)

Multiple sclerosis (MS) is a pathologically complex CNS disease: inflammation, demyelination, and neuroaxonal degeneration occur concurrently and may depend on one another. Current therapies are aimed at the immune-mediated, inflammatory destruction of myelin, whereas axonal degeneration is ongoing and not specifically targeted. Diffusion-weighted magnetic resonance spectroscopy can measure the diffusivity of metabolites in vivo, such as the axonal/neuronal constituent <i>N</i>-acetylaspartate, allowing compartment-specific assessment of disease-related changes. Previously, we found significantly lower <i>N</i>-acetylaspartate diffusivity in people with MS compared to healthy controls (Wood et al., 2012) suggesting that this technique can measure axonal degeneration and could be useful in developing neuroprotective agents. In this longitudinal study, we found that <i>N</i>-acetylaspartate diffusivity decreased by 8.3% (p < 0.05) over 6 months in participants who were experiencing clinical or MRI evidence of inflammatory activity (n = 13), whereas there was no significant change in N-acetylaspartate diffusivity in the context of clinical and radiological stability (n = 6). As <i>N</i>-acetylaspartate diffusivity measurements are thought to more specifically reflect the intra-axonal space, these data suggest that <i>N</i>-acetylaspartate diffusivity can report on axonal health on the background of multiple pathological processes in MS, both cross-sectionally and longitudinally.
Homeodomain Determinants of Major Groove Recognition (1994)

The homeodomain is a highly conserved structural module that binds DNA and participates in protein-protein interactions. Most homeodomains contain residues at positions 47 and 51 which mediate recognition of a TAAT core binding sequence in the major groove. The constraints imposed on the identity of these residues by homeodomain structure and DNA docking have been examined in the context of the POU domain of the Oct-1 transcription factor. A bacterial library, in which POU homeodomain residues 47 and 51 have been randomized, was probed on nitrocellulose filters for the binding of DNA fragments containing the consensus octamer sequence. The residues which provide for the highest affinity interaction with the octamer consensus sequence, and the greatest specificity, are the highly conserved wild-type residues valine 47 and asparagine 51. Interestingly, a class of variants containing arginine at position 51 was also detected in the screen and found to have moderate affinity for the consensus sequence but reduced specificity compared to the wild-type protein. A single variant containing arginine at both positions 47 and 51 was detected when the library was probed with fragments containing nucleotide substitutions at positions expected to be contacted by residues 47 and 51. This variant was used to alter the DNA-binding specificity of a transcriptional regulatory complex which depends upon Oct-1 for DNA recognition. These findings suggest that homeodomain structure and DNA docking constrain in the versatility of the domain in that only a limited set of amino acid determinants can endow the domain with specific, high-affinity DNA binding.
Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models (2017)

Mutations in the glucocerebrosidase gene (<i>GBA</i>) confer a heightened risk of developing Parkinson's disease (PD) and other synucleinopathies, resulting in a lower age of onset and exacerbating disease progression. However, the precise mechanisms by which mutations in <i>GBA</i> increase PD risk and accelerate its progression remain unclear. Here, we investigated the merits of glucosylceramide synthase (GCS) inhibition as a potential treatment for synucleinopathies. Two murine models of synucleinopathy (a Gaucher-related synucleinopathy model, <i>Gba</i><sup><i>D409V/D409V</i></sup> and a A53T-α-synuclein overexpressing model harboring wild-type alleles of <i>GBA</i>, <i>A53T-SNCA</i> mouse model) were exposed to a brain-penetrant GCS inhibitor, GZ667161. Treatment of <i>Gba</i><sup><i>D409V/D409V</i></sup> mice with the GCS inhibitor reduced levels of glucosylceramide and glucosylsphingosine in the central nervous system (CNS), demonstrating target engagement. Remarkably, treatment with GZ667161 slowed the accumulation of hippocampal aggregates of α-synuclein, ubiquitin, and tau, and improved the associated memory deficits. Similarly, prolonged treatment of <i>A53T-SNCA</i> mice with GZ667161 reduced membrane-associated α-synuclein in the CNS and ameliorated cognitive deficits. The data support the contention that prolonged antagonism of GCS in the CNS can affect α-synuclein processing and improve behavioral outcomes. Hence, inhibition of GCS represents a disease-modifying therapeutic strategy for <i>GBA</i>-related synucleinopathies and conceivably for certain forms of sporadic disease.