gebhart/patrepeval huggingface dataset:
Helium ion microscope characterization for Cu / low-k interconnects - SE imaging and focused helium ion beam luminescence detection - (2011)

Several novel imaging modes of the recently developed helium ion microscope (HIM) 1) were explored that may make the HIM a tool of particular value to Cu / low-k (dielectric constant) interconnect structures. Mechanism of the “through dielectric” (2) imaging of the Cu interconnects underneath the low-k SiOC film was proposed, and materials contrast in the low-k regions between Cu lines was imaged which might reflect damaged low-k areas. Furthermore possibility of detection of luminescence induced by the focused helium ion beam using the HIM for materials property characterizations was studied for the first time.
A test-based strategy does not help inform return to work for healthcare workers with COVID-19 (2022)

Objective: To assess the utility of a test-based approach to shorten isolation of healthcare workers with COVID-19 in the setting of the highly transmissible omicron variant Methods: Between December 24th, 2021, to January 5th, 2022 HCWs who tested positive for SARS-CoV-2 were re-tested at least five days since onset of symptoms. Results: 46 sequential fully COVID-19 vaccinated HCWs who had tested positive for SARS-CoV-2 underwent follow up testing. All the isolates were confirmed as omicron variants and only 4 (8.7%) were negative 5 days or more since onset of symptoms., Conclusions: Implementation of a test-based strategy is logistically challenging, increases costs and did not lead to shorter isolation in our institution.
Simultaneous Transmission of Multi-RATs and Mobile Fronthaul in the MMW Bands over an IFoF System (2017)

We propose and demonstrate a simultaneous transmission of LTE-A, 25-GHz OFDM/FBMC radio access, and 96-GHz filtered-OFDM mobile fronthaul signals over a simple and low cost intermediate-frequency-over-fiber system. We confirm the successful transmission of all signals.
Adjustable Passive RFID Skin Mounted Sticker (2019)

Passive Radio Frequency Identification (RFID) can be limited by such aspects as size that make overcoming the capacitive loading introduced by human tissue difficult when intending to produce an efficient antenna with a high read range. It is still possible to design a small and thin RFID tag with a read range above half a meter. Here we present such a design with a diameter of less than 3 cm, By utilizing a breathable polyurethane polymer with two thicknesses, it is possible to use a single tag design for human tissue (dielectric constants ranging from a 22 to 40) with only a slight loss in antenna read range. It is more cost effective to just adjust the polyurethane thickness for a single design than to tune the antenna design itself. Volunteers one and two had read ranges above one meter while volunteer three (with permittivity of 40) caused the largest shift in antenna resonance from 865 MHz (EU band) and required an increase in polyurethane thickness from 1.1 mm to 1.5 mm. However, both designs still produced read ranges above 0.5 meters which could be further tuned with future adjustments to increase read range. This led to a passive RFID design that can be worn by most people with a simple thickness adjustment if needed.
Interactions in the Error-prone Postreplication Repair Proteins hREV1, hREV3, and hREV7 (2001)

Most mutations after DNA damage in yeast Saccharomyces cerevisiae are induced by error-prone translesion DNA synthesis employing scRev1 and DNA polymerase zeta that consists of scRev3 and scRev7 proteins. Recently, the human REV1 (hREV1) and REV3 (hREV3) genes were identified, and their products were revealed to be involved in UV-induced mutagenesis, as observed for their yeast counterparts. Human REV7 (hREV7) was also cloned, and its product was found to interact with hREV3, but the biological function of hREV7 remained unknown. We report here the analyses of precise interactions in the human REV proteins. The interaction between hREV1 and hREV7 was identified by the yeast two-hybrid library screening using a bait of hREV7, which was confirmed by in vitro and in vivo binding assays. The homodimerization of hREV7 was also detected in the two-hybrid analysis. In addition, the precise domains for interaction between hREV7 and hREV1 or hREV3 and for hREV7 homodimerization were determined. Although hREV7 interacts with both hREV1 and hREV3, a stable complex formation of the three proteins was undetectable in vitro. These findings suggest the possibility that hREV7 might play an important role in regulating the enzymatic activities of hREV1 and hREV3 for mutagenesis in response to DNA damage.
The Registry Case Finding Engine: An Automated Tool to Identify Cancer Cases from Unstructured, Free-Text Pathology Reports and Clinical Notes (2007)

The system has been well accepted by our registrars. CaFE can improve the accuracy and efficiency of tumor registry personnel and helps ensure that cancer cases are not overlooked.
A second gene for gonadotropin-releasing hormone: cDNAand expression pattern in the brain. (1994)

In vertebrates, the gonadotropin-releasing hormone (GnRH) decapeptide is secreted from hypothalamic nerve terminals to regulate reproduction via control of synthesis and release of pituitary gonadotropins. Only one GnRH peptide has been found in mammals, with one exception, although numerous other vertebrate species express more than one of the eight known decapeptide forms as shown by immunocytochemical labeling of distinct cell groups in the brain. However, neither the functional nor the evolutionary relationships among these GnRH forms are clear, because only one preprohormone gene sequence from any species has been reported. The most ubiquitous alternative form of GnRH is [His5,Trp7,Tyr8]GnRH (also referred to as chicken-II), which differs from the mammalian sequence at amino acids 5, 7, and 8. This peptide has been shown to have the most potent releasing-hormone activity, although immunocytochemical staining has suggested it is synthesized only in the mesencephalon. Here we report the cloning and expression pattern of the gene for the precursor of this form from the teleost fish Haplochromis burtoni. This is the second GnRH-encoding gene to be characterized in this species. The newly discovered preprohormone gene differs from that previously reported in two ways. First, whereas the original gene predicts only a single associated peptide, this one predicts two associated peptides, both of which appear to be unique. Second, the gene for [His5,Trp7,Tyr8]GnRH is expressed in only one cell group in the mesencephalon. In contrast, the previously reported gene is expressed only in the terminal nerve. The striking differences between the preprohormone structure and localization suggest that the genes coding for the two known GnRH forms in H. burtoni did not arise from a recent duplication event. Interestingly, neither of the two genes found to date in this species is expressed in cells which project from the hypothalamus to the pituitary, suggesting that yet a third gene coding for GnRH may exist.
Korean Insurance Academy's Strategy for Sustainable Growth (2018)

韓国の深刻な高齢化問題は韓国保険学会の持続可能性の脅威となっている状況である。本論文では，韓国保険学会における高齢化問題を考察し，これを解消するための基本戦略および主要政策を紹介する。韓国保険学会は，①未来における保険学者の養成②研究の質的水準の向上③国際交流の拡大④保険関連学会の連携強化および産学との連携拡充などを学会の存続および発展戦略として採択し，あらゆる支援事業を実施している。また，諸外国との連携を通じて，保険関連学会との学術交流を活性化し，countryriskを分散させることを中長期戦略として設定する必要がある。これは韓国保険学会と日本保険学会が共に直面している高齢化問題の効果的な対処策になると思われる。
Online Appendix for Aggregating Privacy-Conscious DERs for Grid Service Provision (2019)

Online appendix for the journal paper "Aggregating Privacy-Conscious DERs for Grid Service Provision".
264-OR: Glucagon Kinetics: Model from First-in-Humans with 13C15N Glucagon (2021)

We recently developed a novel stable glucagon tracer, [13C15N]-glucagon, to study glucagon kinetics and turnover in humans. Here, [13C15N]-glucagon was used to model glucagon kinetics during steady-state conditions in 5 nondiabetic subjects with complete data thus far (age 27±7 y; BMI 25.3±2.4 kg/m2, Mean±SD) who underwent two separate protocols: bolus injection (1497±564 pg/kg) and stop-from-constant infusion (138±33 pg/kg/min) of [13C15N]-glucagon. Arterialized blood was frequently sampled to measure the decay of [13C15N]-glucagon concentrations using tandem mass spectrometry. A linear, single compartment model was necessary and sufficient to reliably describe [13C15N]-glucagon kinetics and estimate both glucagon volume of distribution and clearance rate. The model well predicted the data (Fig. 1) and model parameters were estimated with precision (CV = 6±3 %). Volume of glucagon distribution was 37±9 mL/kg while clearance rate was 8.1±1.5 mL/kg/min. Results suggest that glucagon distributes in a single compartment with a volume of distribution approximately equal to the plasma volume. Additional nondiabetic and subjects with type 1 diabetes are currently under study. This model will be key to study postprandial glucagon turnover.View largeDownload slideView largeDownload slide DisclosureM. Schiavon: None. F. Ruchi: None. Y. R. Yadav: None. R. Basu: None. C. Cobelli: None. C. Dalla man: Research Support; Self; Becton, Dickinson and Company, Sanofi-Aventis Deutschland GmbH. A. Basu: None.FundingNational Institutes of Health (DK085516 to A.B.), (DK029953 to R.B.); Italian Ministry of Education, University and Research (Law 232/2016 to M.S. and C.D.M.)
Phylogenetic Characterization of Histoplasma capsulatum Strains Based on ITS Region Sequences, Including Two New Strains from Thai and Chinese Patients in Japan. (2002)

Two strains of Histoplasma capsulatum var. capsulatum were isolated in Japan: one from a Thai AIDS patient and the other from a Chinese non-immunocompromised patient. The phylogenetical relationship among the two isolates and reference strains of H. capsulatum from other geographical populations was investigated. Random amplified polymorphic DNA (RAPD) analysis of the two H. capsulatum strains showed that they had RAPD band patterns similar to those of the reference Thai isolates and North American strains, although the patterns differed slightly from those of the reference strains. Phylogeny of thirty geographically diverse H. capsulatum isolates representing the three varieties, var. capsulatum, var. duboisii and var. farciminosum were evaluated using nucleotide sequences of the internal transcribed spacer (ITS) region (ITS1-5.8S rDNA -ITS2). We found that the ITS region contained sufficient information to resolve the phylogenetic relationship among the fungal isolates. An unrooted dendrogram constructed from the ITS sequences showed that thirty strains of H. capsulatum could be classified into eight geographic clades; Asia type (i), South America types A (ii) and B (iii), North American types 1 (iv) and 2 (v), H. duboisii types A (vi) and B (vii), and East Asia type (viii). Based on the ITS region sequence analysis, the two strains isolated from the Thai and Chinese patients in Japan were found to be distinct from Asia type (i) in which eight Thai, one Chinese, one English and one Indonesian isolate were included. Some extent of DNA polymorphism was observed between the North America type 1 isolates and the Thai and Chinese strains isolated in Japan. We believe that the Thai and Chinese isolates were unique and propose a new clade, East Asia type (viii) for the two strains. DNA sequence analysis of the ITS region provided useful information to understand the epidemiology and evolution of H. capsulatum.
A Novel and Cost-Effective CsVO3 Quantum Dots for Optoelectronic and Display Applications (2022)

Quantum dots (QDs) have an unparalleled ability to mimic true colors due to their size-tunable optical and electronic properties, which make them the most promising nanoparticles in various fields. Currently, the majority of QDs available in the market are cadmium, indium, and lead-based materials but the toxicity and unstable nature of these QDs restricts their industrial and practical applications. To avoid using heavy metal ions, especially cadmium, the current research is focused on the fabrication of perovskite and vanadate QDs. Herein, we report the facile synthesis of a novel and cost-effective CsVO<sub>3</sub> QDs for the first time. The sizes of the CsVO<sub>3</sub> QDs produced were tuned from 2 to 10 nm by varying the reaction temperature from 140 to 190 °C. On increasing QD size, a continuous red shift was observed in absorption and emission spectra, signifying the presence of quantum confinement. In addition, along with CsVO<sub>3</sub> QDs, the CsVO<sub>3</sub> nanosheets self-assembled microflower-like particles were found as residue after the centrifugation; the X-ray diffraction indicated an orthorhombic structure. Under 365 nm excitation, these CsVO<sub>3</sub> microflower-like particles exhibited broad emission with CIE coordinates in the white emission region. The acquired results suggest that CsVO<sub>3</sub> QDs may represent a new class of cadmium-free materials for optoelectronic and biomedical applications.
Monte Carlo simulation of stoquastic Hamiltonians (2014)

Stoquastic Hamiltonians are characterized by the property that their off-diagonal matrix elements in the standard product basis are real and non-positive. Many interesting quantum models fall into this class including the Transverse field Ising Model (TIM), the Heisenberg model on bipartite graphs, and the bosonic Hubbard model. Here we consider the problem of estimating the ground state energy of a local stoquastic Hamiltonian $H$ with a promise that the ground state of $H$ has a non-negligible correlation with some `guiding' state that admits a concise classical description. A formalized version of this problem called Guided Stoquastic Hamiltonian is shown to be complete for the complexity class MA (a probabilistic analogue of NP). To prove this result we employ the Projection Monte Carlo algorithm with a variable number of walkers. Secondly, we show that the ground state and thermal equilibrium properties of the ferromagnetic TIM can be simulated in polynomial time on a classical probabilistic computer. This result is based on the approximation algorithm for the classical ferromagnetic Ising model due to Jerrrum and Sinclair (1993).
Infectious complications in children treated for hodgkin and non-hodgkin lymphomas in polish pediatric leukemia/lymphoma study group: incidence, epidemiology and etiology (2018)

The objective of this nation-wide study was to evaluate the epidemiology and profile of bacterial (BI), viral (VI), and invasive fungal disease (IFD) in patients treated for non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) between the years 2013-2015. In the analyzed period of time, within the studied group of 328 children diagnosed and treated for lymphomas, at least one infectious complication (IC) was diagnosed i.e. 39.3% children. In these patients there were 350 episodes of IC, therein 80.6% episodes of BI, 11.1% episodes of VI, and 8.3% episodes of IFD. In both groups, NHL and HL patients, a stable level of bacterial infections, with an increase in resistance rates, and increased levels of viral and fungal infections were observed. Profile of BI does not depend on lymphoma type, with predominance of Gram-negative bacteria and higher prevalence of MDR pathogens. The overall survival of lymphoma patients with IC was comparable for different types of infections.
Can composition and preheating improve infiltrant characteristics and penetrability in demineralized enamel? (2020)

The composition of infiltrants can influence their physical properties, viscosity and depth of penetration (DP). Strategies are used to increase the DP, such as the addition of diluents or the use of heat. This study aimed to evaluate the effect of preheating and composition on physical properties and DP of infiltrants in demineralized enamel. The groups were assigned, and the following experimental formulations were made: 25%BisEMA +75%TEGDMA; 25%BisEMA +65%TEGDMA +10%ethanol; 25%BisEMA +65%TEGDMA +10%HEMA; 100%TEGDMA; 90%TEGDMA +10%ethanol; 90%TEGDMA +10%HEMA. The samples were photoactivated at two temperatures (25°C and 55°C). Degree of conversion (DC) was performed using an infrared spectrophotometer. Elastic modulus (E), flexural strength (FS) and contact angle (CA) tests were also performed. The DP of an infiltrant in demineralized enamel was determined by confocal laser scanning microscopy (CLSM) using an indirect labeling technique. The data were analyzed by two-way ANOVA and Tukey's test. DC increased after preheating in all the groups; however, 90%TEGDMA+10%ethanol showed the lowest DC for both temperatures, and the lowest E. Preheating did not influence E or FS. The CA increased at 55°C for most groups, but decreased for groups containing HEMA. Temperature did not seem to influence DP, and Icon showed the lowest DP values. The 100%TEGDMA composition showed more homogeneous penetration, whereas Icon showed heterogeneous and superficial penetration. The preheating technique does not improve all properties in all the material compositions. The composition of a material can influence and improve its properties.
Unambiguous measurement of volume flow using ultrasound (1975)

A new modality for transcutaneous measurement of blood flow is described. Two ultrasonic pulsed Doppler techniques (Doppler imaging and average Doppler shift detection) are combined to measure net flow across an arbitrary sample plane. This estimate of volume flow is independent of lumen shape, orientation, and velocity profile.
Increased Photosensitivity in HL60 Cells Expressing Wild‐Type p53 (1997)

Loss of p53 function has been correlated with decreased sensitivity to chemotherapy and radiation therapy in a variety of human tumors. Comparable analysis of p53 status with sensitivity to oxidative stress induced by photodynamic therapy has not been reported. In the current study we examined photosensitivity in human promyelocytic leukemia HL60 cells exhibiting either wild-type p53, mutated p53 or deleted p53 expression. Experiments were performed using a purpurin, tin ethyl etiopurpurin (SnET2)-, or a porphyrin, Photofrin (PH)-based photosensitizer. Total SnET2 accumulation was comparable in all three cell lines. Uptake of PH was highest in cells expressing wild-type p53 but incubation conditions could be adjusted to achieve equivalent cellular PH levels during experiments that analyzed photosensitivity. Survival measurements demonstrated that HL60 cells expressing wild-type p53 were more sensitive to PH- and SnET2-mediated photosensitization, as well as to UVC irradiation, when compared to HL60 cells exhibiting deleted or mutated p53 phenotypes. A rapid apoptotic response was observed following purpurin- and porphyrin-induced photosensitization in all cell lines. Results of this study indicate that photosensitivity is increased in HL60 cells expressing wild-type p53 and that photosensitizer-mediated oxidative stress can induce apoptosis through a p53-independent mechanism in HL60 cells.
Abstract C103: The combination of PI3kδ-selective inhibition and immunomodulation shows efficacy in solid tumor models (2015)

Abstract Understanding the in vivo responses to immunoregulatory agents provides a basis for building more efficacious combination regimens. Pharmacologic inhibition of the oncogenic PI3Kδ pathway has been shown to be active in patients with hematopoietic malignancies. Recently, genetic inactivation of PI3Kδ in mice was shown to delay the growth of solid tumors, through the inactivation of Treg-mediated suppression of cytotoxic CD8+ T cell responses, suggesting that it may have additional utility in this patient population. We identified a similar immunomodulatory role for the PI3Kδ-selective inhibitor INCB050465 in a preclinical model of pancreatic cancer, where an increase in the number of CD8+ T cells, a decrease in the number of suppressor cells and efficacy were seen. Therefore we explored the potential of INCB050465 in additional preclinical solid tumor models, alone and in combination with other immunotherapeutic agents. INCB050465 inhibited tumor growth in multiple established tumor models which are not dependent upon oncogenic PI3K signaling. Tumor growth inhibition was not observed in these models in immunocompromised mice, demonstrating that the anti-tumor effects of these agents require an intact immune system. To further investigate immune-mediated mechanisms, tumors were analyzed for modulation of gene expression and immune phenotype after mice received short-term treatment. INCB050465 was shown to significantly downregulate the T cell gene signature in tumors, and this was primarily due to depletion of CD4+CD25+FoxP3+ regulatory T cells. As seen previously, the number of CD8+ T cells was shown to be higher in INCB050465-treated tumors. The combination of PI3Kδ and JAK inhibition resulted in enhanced activity in a T-cell-inflamed model by reducing both Treg and M2 macrophages, which promotes re-activation of both CD4+ and CD8+ T cells. In addition, PI3Kδ inhibition and PD-L1 blockade resulted in enhanced efficacy by depleting Treg and prolonging T cell response over time. In summary, pharmacological inhibition of PI3Kδ can enhance anti-tumor immunity by depleting Treg while increasing the numbers of cytotoxic CD8+ T cells. These data support clinical evaluation of the mechanism, and further studies to understand the molecular basis of efficacy and complex cellular responses may provide rationale to identify individuals who may benefit from PI3Kδ inhibitor-based immunotherapy combinations in the clinic. Citation Format: Holly K. Koblish, Liang-Chuan Wang, Michael Hansbury, Yue Zhang, Gengjie Yang, Timothy Burn, Paul Waeltz, Mark Rupar, Eddy Yue, Brent Douty, Thomas Maduskuie, Nikoo Falahatpisheh, Yun-long Li, Andrew Combs, Gregory Hollis, Reid Huber, Peggy Scherle. The combination of PI3kδ-selective inhibition and immunomodulation shows efficacy in solid tumor models. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr C103.
Simplified log likelihood ratio calculation in soft ordered successive interference cancellation for multiple‐input multiple‐output digital video broadcasting‐second generation terrestrial receivers (2014)

This study proposes a soft ordered successive interference cancellation (OSIC) receiver accompanied by a simplified log‐likelihood ratio calculation method for a dual‐polarised multiple‐input multiple‐output (MIMO) digital video broadcasting‐second generation terrestrial system. The future terrestrial transmission systems will be required to provide high data rates for ultra‐high definition television service. For this purpose, dual‐polarised MIMO techniques with a little cross‐antenna interference and high‐order modulation schemes have been considered. As the cross‐antenna interference needs to be removed, a soft OSIC receiver can be used effectively. However, the receiver has to endure high computational complexity for calculating soft values. To reduce it, the authors simplified the calculation based on the decision threshold (DT) method. The main contribution of this study is to extend the conventional DT method, which is restricted to only low‐order modulations, to an algorithmic process applicable to any modulation order. The proposed soft OSIC receiver has about 1 dB degradation from the soft OSIC receiver with the maximum‐likelihood calculation of soft values. The degradation can be fully rewarded by the significantly reduced computational complexity. Furthermore, this study presents an additional possibility of improving the decoding performance by modelling the OSIC equaliser as a biased estimator.