gebhart/patrepeval huggingface dataset:
An rK28-Based Immunoenzymatic Assay for the Diagnosis of Canine Visceral Leishmaniasis in Latin America (2016)

Direct observation of Leishmania parasites in tissue aspirates has shown low sensitivity for the detection of canine visceral leishmaniasis (VL). Therefore in the last quarter century immunoenzymatic tests have been developed to improve diagnosis. The purpose of this study was to develop a fast recombinant K28 antigen, naked-eye qualitative enzyme-linked immunosorbent assay (VL Ql-ELISA) and a quantitative version (VL Qt-ELISA), and to display it in a kit format, whose cutoff value (0.156) was selected as the most adequate one to differentiate reactive from nonreactive samples. Considering 167 cases and 300 controls, sensitivity was 91% for both assays and specificity was 100% and 98.7% in Ql-ELISA and Qt-ELISA, respectively. Positive predictive values were 100% and 97.4% for Ql-ELISA and Qt-ELISA, respectively, and negative predictive values were 95.2% for both ELISAs. Reagent stability, reliability studies, including periodic repetitions and retest of samples, cutoff selection, and comparison of rK28 ELISAs with rK39 immunochromatographic test, were the international criteria that supported the quality in both kits. The performance of both ELISA kits in this work confirmed their validity and emphasized their usefulness for low-to-medium complexity laboratories.
ΣΙΔΗΡΟΣ ΚΑΙ ΟΞΕΙΔΩΤΙΚΟ ΣΤΡΕΣ: ΟΜΟΙΟΣΤΑΣΗ ΤΟΥ ΣΙΔΗΡΟΥ ΣΤΟΝ ΟΡΓΑΝΙΣΜΟ (2015)

Eλeύθeρeς ρίζeς:Βιοχημeία και Παθολογική Βιοχημeία [ΠΑΝEΠΙΣΤΗΜΙΟ ΙΩΑΝΝΙΝΩΝ, ΣΧΟΛΗ EΠΙΣΤΗΜΩΝ ΥΓEΙΑΣ, ΤΜΗΜΑ ΙΑΤΡΙΚΗΣ]
1683: A Prospective Randomized Clinical Trial Comparing Levels of Symptoms and Discomfort Associated with Two Investigational and Two Currently Marketed Ureteral Stents (2005)

You have accessJournal of UrologyModerated Poster, Wednesday, May 25, 2005, 3:30 - 5:30 pm1 Apr 20051683: A Prospective Randomized Clinical Trial Comparing Levels of Symptoms and Discomfort Associated with Two Investigational and Two Currently Marketed Ureteral Stents Glenn M. Preminger, James E. Lingeman, Evan Goldfischer, Manoj Monga, Brian K. Auge, Paul K. Pietrow, Dean G. Assimos, Richard Norman, John Dushinski, Joseph N. Macaluso, David M. Hoenig, Richard J. Kahnoski, and Jaime Landman Glenn M. PremingerGlenn M. Preminger More articles by this author , James E. LingemanJames E. Lingeman More articles by this author , Evan GoldfischerEvan Goldfischer More articles by this author , Manoj MongaManoj Monga More articles by this author , Brian K. AugeBrian K. Auge More articles by this author , Paul K. PietrowPaul K. Pietrow More articles by this author , Dean G. AssimosDean G. Assimos More articles by this author , Richard NormanRichard Norman More articles by this author , John DushinskiJohn Dushinski More articles by this author , Joseph N. MacalusoJoseph N. Macaluso More articles by this author , David M. HoenigDavid M. Hoenig More articles by this author , Richard J. KahnoskiRichard J. Kahnoski More articles by this author , and Jaime LandmanJaime Landman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)35805-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1683: A Prospective Randomized Clinical Trial Comparing Levels of Symptoms and Discomfort Associated with Two Investigational and Two Currently Marketed Ureteral Stents." The Journal of Urology, 173(4S), pp. 456–457 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 456-457 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Glenn M. Preminger More articles by this author James E. Lingeman More articles by this author Evan Goldfischer More articles by this author Manoj Monga More articles by this author Brian K. Auge More articles by this author Paul K. Pietrow More articles by this author Dean G. Assimos More articles by this author Richard Norman More articles by this author John Dushinski More articles by this author Joseph N. Macaluso More articles by this author David M. Hoenig More articles by this author Richard J. Kahnoski More articles by this author Jaime Landman More articles by this author Expand All Advertisement PDF downloadLoading ...
Plant Selenium Hyperaccumulation Affects Rhizosphere: Enhanced Species Richness and Altered Species Composition (2018)

Little is known about the microbiomes associated with plants with unusual properties, including plants that hyperaccumulate toxic elements such as selenium (Se). Se hyperaccumulators contain up to 1.5% of their dry weight in Se, concentrations shown to affect ecological interactions with herbivores, fungal pathogens and neighboring plants. Hyperaccumulators also enrich their surrounding soil with Se, which may alter the rhizobiome. To investigate whether plant Se affects rhizobacterial diversity and composition, we used a combination of culture-independent and culture-based approaches. Sequencing of 16S rRNA gene amplicons using the Illumina platform revealed that the rhizosphere microbiomes of Se hyperaccumulators were significantly different from nonaccumulators from the same site, with a higher average relative abundance of Pedobacter and Deviosa. Additionally, hyperaccumulators harbored a higher rhizobacterial species richness when compared with nonaccumulators from the same family on the same site. Independent from Se present at the site or in the host plant, the bacterial isolates were extremely resistant to selenate and selenite (up to 200 mM) and could reduce selenite to elemental Se. In conclusion, Se hyperaccumulation does not appear to negatively affect rhizobacterial diversity, and may select for certain taxa in the rhizosphere microbiome. Additionally, Se resistance in hyperaccumulator-associated bacteria and archaea may be widespread and not under selection by the host plant.
Four-, Five-, and Six-Coordinate Complexes Containing 1,1,7,7-Tetraethyldiethylenetriamine (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFour-, Five-, and Six-Coordinate Complexes Containing 1,1,7,7-TetraethyldiethylenetriamineZvi Dori and Harry B. GrayCite this: J. Am. Chem. Soc. 1966, 88, 7, 1394–1398Publication Date (Print):April 1, 1966Publication History Published online1 May 2002Published inissue 1 April 1966https://pubs.acs.org/doi/10.1021/ja00959a012https://doi.org/10.1021/ja00959a012research-articleACS PublicationsRequest reuse permissionsArticle Views159Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cognitive Dysfunction and Contact Sports (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Perceived Obstacles of Colorectal Cancer Screening and Their Associated Factors among 10,078 Chinese Participants (2013)

The proportions of perceptual barriers of CRC screening were high among these participants. Those with these associated factors should receive more thorough explanation of the screening test procedures.
Origin of Unusual Acidity and Li+ Diffusivity in a Series of Water-in-Salt Electrolytes (2020)

Superconcentrated aqueous electrolytes ("water-in-salt" electrolytes, or WiSEs) enable various aqueous battery chemistries beyond the voltage limits imposed by the Pourbaix diagram of water. However, their detailed structural and transport properties remain unexplored and could be better understood through added studies. Here, we report on our observations of strong acidity (pH 2.4) induced by lithium bis(trifluoromethane sulfonyl)imide (LiTFSI) at superconcentration (at 20 mol/kg). Multiple nuclear magnetic resonance (NMR) and pulsed-field gradient (PFG) diffusion NMR experiments, density functional theory (DFT) calculations, and molecular dynamics (MD) simulations reveal that such acidity originates from the formation of nanometric ion-rich structures. The experimental and simulation results indicate the separation of water-rich and ion-rich domains at salt concentrations ≥5 m and the acidity arising therefrom is due to deprotonation of water molecules in the ion-rich domains. As such, the ion-rich domain is composed of hydrophobic -CF<sub>3</sub> (of TFSI<sup>-</sup>) and hydrophilic hydroxyl (OH<sup>-</sup>) groups. At 20 m concentration, the tortuosity and radius of water diffusion channels are estimated to be ∼10 and ∼1 nm, respectively, which are close to values obtained from hydrated Nafion membranes that also have hydrophobic polytetrafluoroethylene (PTFE) backbones and hydrophilic channels consisting of SO<sub>3</sub><sup>-</sup> ion cluster networks providing for the transport of ions and water. Thus, we have discovered the structural similarity between WiSE and hydrated Nafion membranes on the nanometer scale.
An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component (2012)

Intrinsically disordered proteins play causative roles in many human diseases. Their overexpression is toxic in many organisms, but the causes of toxicity are opaque. In this paper, we exploit yeast technologies to determine the root of toxicity for one such protein, the yeast prion Rnq1. This protein is profoundly toxic when overexpressed but only in cells carrying the endogenous Rnq1 protein in its [RNQ(+)] prion (amyloid) conformation. Surprisingly, toxicity was not caused by general proteotoxic stress. Rather, it involved a highly specific mitotic arrest mediated by the Mad2 cell cycle checkpoint. Monopolar spindles accumulated as a result of defective duplication of the yeast centrosome (spindle pole body [SPB]). This arose from selective Rnq1-mediated sequestration of the core SPB component Spc42 in the insoluble protein deposit (IPOD). Rnq1 does not normally participate in spindle pole dynamics, but it does assemble at the IPOD when aggregated. Our work illustrates how the promiscuous interactions of an intrinsically disordered protein can produce highly specific cellular toxicities through illicit, yet highly specific, interactions with the proteome.
Reliable tantalum-gate fully-depleted-SOI MOSFET technology featuring low-temperature processing (1997)

A reliable tantalum (Ta)-gate device technology, which can drastically reduce the number of process steps, has been developed. Ta-gate fully-depleted-silicon-on-insulator (FDSOI) MOSFETs with 0.15-/spl mu/m gate length by low-temperature processing below 500/spl deg/C after the gate oxide formation have good on/off characteristics. Comprehensive design guidelines for Ta-gate MOSFETs in the deep-submicrometer regime is provided by investigating a wide range of performance and reliability constraints on the process temperature and the SOI thickness. In the guideline, the recrystallization of the source/drain region gives inferior limits of the SOI thickness and the process temperature. Thermal reaction between Ta and SiO/sub 2/ films sets a superior limit of the process temperature, and a short-channel effect sets a superior limit of the SOI thickness.
(Invited) Red-Emitting Manganese-Doped Aluminum Nitride Phosphor (2016)

We report high efficiency luminescence with a manganese-doped aluminum nitride red-emitting phosphor under 254 nm excitation, as well as its excellent lumen maintenance in fluorescent lamp conditions, making it a candidate replacement for the widely deployed europium-doped yttria red phosphor. Solid-state reaction of aluminum nitride powders with manganese metal at 1900 °C, 10 atm N 2 in a reducing environment results in nitrogen deficiency, as revealed by diffuse reflectance spectra. When these powders are subsequently annealed in flowing nitrogen at 1650 °C, higher nitrogen content is recovered, resulting in white powders. Silicon was added to samples as an oxygen getter to improve emission efficiency. NEXAFS spectra and DFT calculations indicate that the Mn dopant is divalent. From DFT calculations, the UV absorption band is proposed to be due to an aluminum vacancy coupled with oxygen impurity dopants, and Mn 2+ is assumed to be closely associated with this site. In contrast with some previous reports, we find that the highest quantum efficiency with 254 nm excitation (Q.E. = 0.86±0.14) is obtained in aluminum nitride with a low manganese doping level of 0.06 mol%. The principal Mn 2+ decay of 1.25 ms is assigned to non-interacting Mn sites, while additional components in the microsecond range appear with higher Mn doping, consistent with Mn clustering and resultant exchange coupling. Slower components are present in samples with low Mn doping, as well as strong afterglow, assigned to trapping on shallow traps followed by detrapping and subsequent trapping on Mn. Figure 1
Soybean BARCSoySNP6K: An assay for soybean genetics and breeding research (2020)

The limited number of recombinant events in recombinant inbred lines suggests that for a biparental population with a limited number of recombinant inbred lines, it is unnecessary to genotype the lines with many markers. For genomic prediction and selection, previous studies have demonstrated that only 1000-2000 genome-wide common markers across all lines/accessions are needed to reach maximum efficiency of genomic prediction in populations. Evaluation of too many markers will not only increase the cost but also generate redundant information. We developed a soybean (Glycine max) assay, BARCSoySNP6K, containing 6000 markers, which were carefully chosen from the SoySNP50K assay based on their position in the soybean genome and haplotype block, polymorphism among accessions and genotyping quality. The assay includes 5000 single nucleotide polymorphisms (SNPs) from euchromatic and 1000 from heterochromatic regions. The percentage of SNPs with minor allele frequency >0.10 was 95% and 91% in the euchromatic and heterochromatic regions, respectively. Analysis of progeny from two large families genotyped with SoySNP50K versus BARCSoySNP6K showed that the position of the common markers and number of unique bins along linkage maps were consistent based on the SNPs genotyped with the two assays; however, the rate of redundant markers was dramatically reduced with the BARCSoySNP6K. The BARCSoySNP6K assay is proven as an excellent tool for detecting quantitative trait loci, genomic selection and assessing genetic relationships. The assay is commercialized by Illumina Inc. and being used by soybean breeders and geneticists and the list of SNPs in the assay is an ideal resource for SNP genotyping by targeted amplicon sequencing.
E-commerce in Your Inbox: Product Recommendations at Scale (2016)

In recent years online advertising has become increasingly ubiquitous and effective. Advertisements shown to visitors fund sites and apps that publish digital content, manage social networks, and operate e-mail services. Given such large variety of internet resources, determining an appropriate type of advertising for a given platform has become critical to financial success. Native advertisements, namely ads that are similar in look and feel to content, have had great success in news and social feeds. However, to date there has not been a winning formula for ads in e-mail clients. In this paper we describe a system that leverages user purchase history determined from e-mail receipts to deliver highly personalized product ads to Yahoo Mail users. We propose to use a novel neural language-based algorithm specifically tailored for delivering effective product recommendations, which was evaluated against baselines that included showing popular products and products predicted based on co-occurrence. We conducted rigorous offline testing using a large-scale product purchase data set, covering purchases of more than 29 million users from 172 e-commerce websites. Ads in the form of product recommendations were successfully tested on online traffic, where we observed a steady 9% lift in click-through rates over other ad formats in mail, as well as comparable lift in conversion rates. Following successful tests, the system was launched into production during the holiday season of 2014.
Poly(ester-anhydrides) Derived from Esters of Hydroxy Acid and Cyclic Anhydrides (2022)

The alternating architecture and hydrophobic side chains hinder hydrolytic cleavage and anhydride interchange in poly(sebacic acid-ricinoleic acid) (P(SA-RA)), which provides stable polyanhydrides at room temperature. In this report, a series of polyanhydrides were designed to investigate the effect of ester bonds, hydrophobic side chains, phenyl moieties, and their distance from anhydride bonds on their stability and properties. Polyanhydrides with alternating architecture are constructed by the polymerization of ester-diacids prepared from ricinoleic or other hydroxy acids with anhydrides such as succinic, maleic, and phthalic anhydrides. The hydrophobic side chains are designed closer to anhydride bonds to investigate hindrance to hydrolytic cleavage and anhydride interchange. Polyanhydrides were obtained by the activation of ester-diacid using acetic anhydride followed by melt condensation. The reactions were monitored by NMR, Fourier transform infrared (FTIR), and gel permeation chromatography (GPC). The synthesized poly(ester-anhydride)s with a shorter chain length compared to P(SA-RA) were stable at room temperature. The hydrolytic degradation studies reveal that the phenyl moiety present in poly(ricinoleic acid phthalate) (PRAP) and poly(hydroxystearic acid phthalate) (PHSAP) reduces the hydrolysis of anhydride bonds. Poly(hydroxyoctanoic acid succinate) (PHOAS) demonstrates the highest molecular weight of all tested polymers. The results reveal that the presence of hydrophobic side chains, phenyl moieties, and their distance from anhydride bonds significantly improves the stability. These stable polyanhydrides can provide convenience to use in control drug-delivery applications. The <i>in vitro</i> drug release study using ibuprofen shows that polymers with aromatic units such as PRAP and PHSAP establish sustained release, which presents more than 50 and 40% of ibuprofen over a period of 28 days.
<title>Computational complexity evaluation of JPEG 2000</title> (2000)

Implementation complexity will have a dramatic influence in facilitating the deployment of the JPEG-2000 technology in consumer market products. This paper addresses the computational complexity evaluation of the new standard's compression engine. A non-optimized C code implementation of JPEG-2000 is profiled at run time using an automatic profiling tool built in house. The computational complexity measurements generated by the profiler are presented and discussed in the paper. The comparison between JPEG-2000 and JPEG baseline computational complexity is also presented.
Twenty years of PWM AC drives: when secondary issues become primary concerns (2002)

With major control and power module advances incorporated in third generation AC adjustable speed drives (ASD), industry interest has shifted to applications and secondary issues. The paper traces the rise of secondary issues to primary concerns. Among the secondary issues discussed are: effects of high dv/dt on system performance, motor terminal overvoltages with long cables, and the contribution of pulse width modulated (PWM) voltage source inverters to bearing currents.
Transforming Growth Factor-β-mediated Chondrogenesis of Human Mesenchymal Progenitor Cells Involves N-cadherin and Mitogen-activated Protein Kinase and Wnt Signaling Cross-talk (2003)

The multilineage differentiation potential of adult tissue-derived mesenchymal progenitor cells (MPCs), such as those from bone marrow and trabecular bone, makes them a useful model to investigate mechanisms regulating tissue development and regeneration, such as cartilage. Treatment with transforming growth factor-beta (TGF-beta) superfamily members is a key requirement for the in vitro chondrogenic differentiation of MPCs. Intracellular signaling cascades, particularly those involving the mitogen-activated protein (MAP) kinases, p38, ERK-1, and JNK, have been shown to be activated by TGF-betas in promoting cartilage-specific gene expression. MPC chondrogenesis in vitro also requires high cell seeding density, reminiscent of the cellular condensation requirements for embryonic mesenchymal chondrogenesis, suggesting common chondro-regulatory mechanisms. Prompted by recent findings of the crucial role of the cell adhesion protein, N-cadherin, and Wnt signaling in condensation and chondrogenesis, we have examined here their involvement, as well as MAP kinase signaling, in TGF-beta1-induced chondrogenesis of trabecular bone-derived MPCs. Our results showed that TGF-beta1 treatment initiates and maintains chondrogenesis of MPCs through the differential chondro-stimulatory activities of p38, ERK-1, and to a lesser extent, JNK. This regulation of MPC chondrogenic differentiation by the MAP kinases involves the modulation of N-cadherin expression levels, thereby likely controlling condensation-like cell-cell interaction and progression to chondrogenic differentiation, by the sequential up-regulation and progressive down-regulation of N-cadherin. TGF-beta1-mediated MAP kinase activation also controls WNT-7A gene expression and Wnt-mediated signaling through the intracellular beta-catenin-TCF pathway, which likely regulates N-cadherin expression and subsequent N-cadherin-mediated cell-adhesion complexes during the early steps of MPC chondrogenesis.
Synthesis of 14C‐radiolabelled tilmicosin (1989)

Abstract Tilmicosin was radiolabelled with carbon‐14 on the 3,5‐dimethylpiperidinyl sidechain as a requirement for animal metabolism studies. A new radiosynthesis of 3,5‐dimethyl‐piperidine was developed for this purpose. Incorporation into the desmycosin nucleus was accomplished by a reductive amination reaction.