gebhart/patrepeval huggingface dataset:
An improved synthesis of carbocyclic and heterocyclic arene imines (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn improved synthesis of carbocyclic and heterocyclic arene iminesMoshe Weitzberg, Zeev Aizenshtat, Parvin Jerushalmy, and Jochanan BlumCite this: J. Org. Chem. 1980, 45, 21, 4252–4254Publication Date (Print):October 1, 1980Publication History Published online1 May 2002Published inissue 1 October 1980https://pubs.acs.org/doi/10.1021/jo01309a046https://doi.org/10.1021/jo01309a046research-articleACS PublicationsRequest reuse permissionsArticle Views262Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Figure Legends 1-7 from <i>Enterococcus faecalis</i> Induces Aneuploidy and Tetraploidy in Colonic Epithelial Cells through a Bystander Effect (2023)

Supplementary Figure Legends 1-7 from &lt;i&gt;Enterococcus faecalis&lt;/i&gt; Induces Aneuploidy and Tetraploidy in Colonic Epithelial Cells through a Bystander Effect
Towards defect free forming of multi-stacked composite aerospace components using tailored interlayer properties (2016)

Use of lightweight materials is an important part of reduction of fuel consumption by commercial aircraft. A considerable number of structural aircraft parts are therefore built of thin layers of epoxy pre-impregnated carbon fibres stacked to laminates. Manufacturing these by hand is costly and different methods of automation have therefore been developed. One cost-effective way of manufacturing is Automated Tape Lay-up of flat stacks followed by a Hot Drape Forming operation. A well-known problem in the industry within forming is fibre wrinkling, which can cause a serious strength knock down. The focus of this thesis has therefore been on understanding how and why wrinkles develop during forming of multi-layer stacks and, based on this, investigate different methods for process and material improvements. The work presented initially investigates the dependency between stacking sequence and wrinkle development. It is shown that wrinkle free forming can be obtained by changing the fibre stacking order. In the following investigation it is shown that the wrinkles cannot be entirely eliminated by local stiffening of the critical layers. In a, related study it is shown that different kinds of wrinkles develops during forming; wrinkles may be either due to global buckling of the entire lay-up or local compression of single layers. Global buckling is due to excessive material. Local compression occurs as the material shear during forming. The work presented leads to an understanding of the importance of making the beneficial neighbouring fibre layers interact during forming. One way to connect neighbouring layers is to tailor the interlayer properties. A study is presented that shows how local manipulation of interlayer properties may steer the multi-layered material into a different deformation mechanisms. The manipulation in this thesis is performed using Multi Wall Carbon Nano Tubes, thermoplastic veils or consolidation of thermoplastic toughener particle interlayers.
The Importance of Fullerene Percolation in the Mixed Regions of Polymer–Fullerene Bulk Heterojunction Solar Cells (2012)

Abstract Most optimized donor‐acceptor (D‐A) polymer bulk heterojunction (BHJ) solar cells have active layers too thin to absorb greater than ∼80% of incident photons with energies above the polymer's band gap. If the thickness of these devices could be increased without sacrificing internal quantum efficiency, the device power conversion efficiency (PCE) could be significantly enhanced. We examine the device characteristics of BHJ solar cells based on poly(di(2‐ethylhexyloxy)benzo[1,2‐ b :4,5‐ b ′]dithiophene‐ co ‐octylthieno[3,4‐ c ]pyrrole‐4,6‐dione) (PBDTTPD) and [6,6]‐phenyl‐C 61 ‐butyric acid methyl ester (PCBM) with 7.3% PCE and find that bimolecular recombination limits the active layer thickness of these devices. Thermal annealing does not mitigate these bimolecular recombination losses and drastically decreases the PCE of PBDTTPD BHJ solar cells. We characterize the morphology of these BHJs before and after thermal annealing and determine that thermal annealing drastically reduces the concentration of PCBM in the mixed regions, which consist of PCBM dispersed in the amorphous portions of PBDTTPD. Decreasing the concentration of PCBM may reduce the number of percolating electron transport pathways within these mixed regions and create morphological electron traps that enhance charge‐carrier recombination and limit device quantum efficiency. These findings suggest that (i) the concentration of PCBM in the mixed regions of polymer BHJs must be above the PCBM percolation threshold in order to attain high solar cell internal quantum efficiency, and (ii) novel processing techniques, which improve polymer hole mobility while maintaining PCBM percolation within the mixed regions, should be developed in order to limit bimolecular recombination losses in optically thick devices and maximize the PCE of polymer BHJ solar cells.
Transmission solutions and architectures for heterogeneous networks built as C-RANs (2012)

A novel end-to-end transport network solution is proposed to meet the operational and technical challenges of heterogeneous networks built as C-RANs with centralized base band processing and CPRI links. The flexibility of the proposed architecture to support distributed architectures and Ethernet links is also described and the results of a C-RAN proof of concept demonstration are discussed. Substantiated by the evolution of key optical technologies, including a novel WDM-PON based solution, we conclude that backhaul and metro network strategies need to flexibly support both centralized and distributed radio baseband solutions, as well as being multiservice capable. Additionally, as a complement to fiber, we propose use of the 70/80 GHz frequency band (E-band) to provide high performance microwave links for both centralized and distributed architectures.
Effects of Mechanical Fatigue on the Bending Properties of the Porcine Bioprosthetic Heart Valve (1999)

The mechanisms underlying the failure of porcine bioprosthetic aortic heart valves are not well understood. One possible explanation is that delaminations of the layered leaflet structure occur through flexion, leading to calcification and further delaminations, and finally resulting in valve failure. We investigated the changes in flexural rigidity of the belly of aortic valve cusps subjected to accelerated durability testing. We used three-point bending wherein a load was applied to the center of each specimen by a thin stainless steel bar calibrated to a known load-displacement relationship. Ten circumferential and 15 radial specimens from valves fatigued to 0, 50, 100, and 200 million cycles were flexed both with and against the curvature of the cusp. Linear beam theory was applied as a means to compare the relative bending stiffness between groups. Although specimens aligned to the circumferential direction were stiffer when bent against the cuspal curvature, the radial oriented specimens exhibited no bending directional dependence. Both the radial and circumferential specimens experienced a significant decrease in the bending stiffness with an increased number of accelerated test cycles. Overall, our results suggest that it is the fibrosa that experiences the greatest loss of stiffness with mechanically induced fatigue damage.
Functional characteristics of antibodies induced by Arg‐gingipain (HRgpA) and Lys‐gingipain (Kgp) from Porphyromonas gingivalis (2001)

Arginine-specific gingipain (HRgpA) and lysine-specific gingipain (Kgp), enzymes produced by Porphyromonas gingivalis, may be candidates for an anti-P. gingivalis vaccine. The purpose of our study was to determine whether HRgpA and Kgp have opsonic target sites and whether these sites are available and accessible on intact P. gingivalis cells. Rabbits were used to generate polyclonal antibodies to both proteins. Animals were immunized and immunoglobulin G (IgG) fractions were isolated from preimmune and immune sera. Functional characteristics of the antibodies were assessed by determining antibody titers by enzyme-linked immunosorbent assay (ELISA), generating Western immunoblots, and measuring antibody enhancement of P. gingivalis opsonization, phagocytosis and killing by polymorphonuclear leukocytes (PMN) of intact cells of strains of P. gingivalis representative of the four serotypes. Strains studied included 33277 (serotype A), A7A1-28 (serotype B), W50 (serotype C) and 381 (serotype D). Both HRgpA and Kgp induced high titers of IgG antibody. Anti-HRgpA and anti-Kgp bound to both HRgpA and Kgp demonstrating a large proportion of shared antigenic epitopes. The two antibodies bound equally well to all four P. gingivalis serotypes with titers ranging from 77 to 205 ELISA units when compared to preimmune IgG set at 1 ELISA unit. The immunoblot patterns of binding of the two antibodies to HRgpA and Kgp and to sonicates of the four P. gingivalis serotypes were virtually identical. Both antibodies detected components in HRgpA at 27, 35 and 45 kDa and in Kgp at 27, 32, 35, 40 and 55 kDa. The antibodies also detected components at or near these same positions in addition to multiple high molecular mass components in the cell sonicates of P. gingivalis. Both proteins induced antibodies that significantly enhanced opsonization as assessed by chemiluminescence, with values ranging from 130 mV to 375 mV for anti-HRgpA IgG and from 240 mV to 475 mV for anti-Kgp IgG. Both antibodies significantly enhanced PMN-mediated bacterial killing of the four P. gingivalis serotypes, although the percentage of killing varied among the serotypes (24-81% for anti-HRgpA and 37-89% for anti-Kgp). Thus, both HRgpA and Kgp express opsonic target sites and induce high titers of antibodies that opsonize and enhance killing of all four serotypes of P. gingivalis. These two proteins appear to be potential candidate antigens for an anti-P. gingivalis vaccine.
Investigation of the Electrode / Electrolyte Interphase for Air-Exposed LiFePO4 Nano-Powders (2013)

Abstract not Available.
Enantioselective activation of the peroxisome proliferator-activated receptor. (1993)

A cell-based transactivation assay was established using the mouse full-length peroxisome proliferator-activated receptor (PPAR) cDNA sequence and the positive peroxisome proliferator-responsive regulatory element (-578 to -553) of the rat acyl-CoA oxidase gene promoter. Activation of the reporter plasmid was dependent on co-transfection of the full-length PPAR cDNA, and the response was greatly stimulated, up to 100-fold, by peroxisome proliferators such as Wy-14,643 ([4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid), nafenopin (2-methyl-2[p-(1,2,3,4-tetrahydro-1-naphthyl)phenoxy]-propionic acid), and clofibric acid (2-([p]-chlorophenoxy)-2-methylpropionic acid). Activation of the reporter plasmid promoter by the full-length PPAR cDNA also occurred at peroxisomal proliferator concentrations 40 times lower than that required for similar stimulation by a glucocorticoid-PPAR chimeric receptor. By using the stereoisomers of MK-571 ((+-)-3-(((3-(2-(7-chloro-2-quinolinyl)ethenyl)-phenyl)((3- (dimethylamino)-3-oxopropyl)-thio)methyl)-thio)propanoic acid), a potent leukotriene D4 receptor antagonist, we could show enantioselective activation of PPAR. The use of this compound in mice results in peroxisome proliferation; however, nearly all of the peroxisome proliferating activity can be attributed to the S enantiomer. Our results show a similar enantiomeric discrimination in PPAR activation of the reporter plasmid promoter, where again most of the activity can be attributed to the S enantiomer. The equivalent activities of these stereoisomers both in vivo and in the PPAR transactivation assay strongly implicate PPAR as a major component of the peroxisome proliferating mechanism in rodents.
Calibration of OPC models for multiple focus conditions (2004)

Ability to predict process behavior under defocus has until now relied on explicit calculations, which while accurate, cannot be realistically used in full-chip optical and process correction strategies due to the long run times. In this work, we have applied a vector model for the optics, and a compact model for the resist development process. Simulations with these models are fast enough to be the basis of full-chip OPC. We verify this strategy with an independent set of measurements, and compare it to current lithographic process fitting strategies. The results indicate that by describing optical processes as accurately as possible, the model accuracy improves over a wider range of defocus conditions when compared to the traditional calibration method. As long as the calibration process successfully decouples optical and resist effects, relatively simple resist models deliver excellent accuracy within the noise level of the metrology measurements. Our data are based on one-dimensional and two-dimensional results using a 193nm system using 0.75 NA and off axis illumination with 6% attenuated phase shift mask. In all cases, a wide variety of sub-resolution assist feature rules were used in order to further test the ability of the models to predict various optical and resist environments.
Influence of time and temperature on the kinetics of thermotolerance in L1A2 cells in vitro. (1982)

The overall importance of the primary heat treatment temperature and heating time for the degree and kinetics of thermotolerance was investigated in L1A2 cells in vitro. The degree and time course of thermotolerance developed following primary heating were independent of the priming temperature (in the range 41-44 degrees), if the heating time was adjusted to give identical survival levels. A pretreatment at these temperatures with a survival level of approximately 8%, equivalent to 90 min at 42 degrees, resulted in maximal thermotolerance at a 10-hr interval with a thermotolerance ratio (TTRmax) of approximately 4.3. This was also found irrespective of the temperature (in the range 41-45 degrees) of the second heat treatment. Preheating of cells at 42 degrees for 45, 90, 110, or 135 min corresponding to survival levels of approximately 40, 8, 3.2, and 1.8%, respectively, induced a subsequent delay of 0.8 to 5.8 hr in the onset of thermotolerance. In addition, with more severe primary heat treatments, the delay period, the TTRmax, and the time interval at 37 degrees necessary to develop TTRmax increased. Maximal thermotolerance was obtained at an interval of 6, 10, 13, and 16 hr, respectively, with TTRmax's of 2.9, 4.2, 5.3, and 5.9, respectively. In contrast, the rate of both development and decay of thermotolerance was independent of the primary heating time. These data indicate that the degree and kinetics of thermotolerance in L1A2 cells depend on the survival level following the primary heating irrespective of the treatment temperature and heating time used to obtain this survival level.
Data from Novel Changes in Glycosylation of Serum Apo-J in Patients with Hepatocellular Carcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and the occurrence of HCC has more than doubled in the United States in the past decade. Early detection is considered key to reducing the mortality of HCC.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; Using two-dimensional gel electrophoresis and high-performance liquid chromatography we have analyzed the glycosylation of Apo-J from healthy controls, patients with liver cirrhosis, or those with HCC.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Apo-J in the serum from patients with HCC had decreased levels of (β-1,4) triantennary N-linked glycan compared with the healthy controls or patients with liver cirrhosis. We analyzed this change in an independent cohort of 76 patients with HCC, 32 with cirrhosis, and 43 infected with hepatitis C virus using the &lt;i&gt;Datura stramonium&lt;/i&gt; lectin (DSL), which binds to (β-1,4) triantennary N-linked glycan. The level of DSL-reactive Apo-J allowed us to differentiate HCC from cirrhosis with an area under the receiver operating characteristic curve (AUROC) of 0.852. When Apo-J was combined with other serum biomarkers such as α-fetoprotein (AFP) and fucosylated kininogen by using a multivariate logistic regression model, the AUROC increased to 0.944, a value much greater than that observed with AFP alone (AUROC of 0.765).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; The glycosylation of Apo-J is a useful marker when used alone or in combination with outer makers for the early detection of HCC.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Impact:&lt;/b&gt; The potential use of a combination of AFP, DSL-reactive Apo-J, and fucosylated kininogen as a biomarker of HCC would have great value in the management of patients with liver disease. &lt;i&gt;Cancer Epidemiol Biomarkers Prev; 20(6); 1222–9. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
LSM-Based Secure System Monitoring Using Kernel Protection Schemes (2010)

Monitoring a process and its file I/O behaviors is important for security inspection for a data center server against intrusions, malware infection and information leakage. In the case of the Linux kernel 2.6, a set of hook functions called the Linux Security Module (LSM) has been implemented in order to monitor and control the system calls. By using the LSM we can inspect the activity of unknown malicious processes. However, a sophisticated attacker could breach the kernel configurations using the rootkits. Furthermore since the monitoring results of the malicious process activity are stored as a file on Hard Disk Drive (HDD), it will be easily manipulated by the attacker. In this paper, we propose a secure monitoring scheme that addresses the attacks against the monitoring module and its result for security inspection of the data center server. The monitoring module is implemented as a LSM-based function and protected by the kernel protection technique. The integrity of the monitoring result is guaranteed by using a Mandatory Access Control (MAC) of the Linux kernel and a mechanism of the trusted process invocation. This mechanism can serve as an infrastrucuture of secure inspection platform for data center server because the integrity of the monitoring module and its result is guaranteed.
Low-level laser therapy for spinal cord injury in rats: effects of polarization (2013)

The effects of laser polarization on the efficacy of near-infrared low-level laser therapy for spinal cord injury (SCI) are presented. Rat spinal cords were injured with a weight-drop device, and the lesion sites were directly irradiated with a linearly polarized 808-nm diode laser positioned either perpendicular or parallel to the spine immediately after the injury and daily for five consecutive days. Functional recovery was assessed daily by an open-field test. Regardless of the polarization direction, functional scores of SCI rats that were treated with the 808-nm laser irradiation were significantly higher than those of SCI alone group (Group 1) from day 5 after injury. The locomotive function of SCI rats irradiated parallel to the spinal column (Group 3) was significantly improved from day 10 after injury, compared to SCI rats treated with the linear polarization perpendicular to the spinal column (Group 2). There were no significant differences in ATP contents in the injured tissue among the three groups. We speculate that the higher efficacy with parallel irradiation is attributable to the deeper light penetration into tissue with anisotropic scattering.
Index compression (2008)

Class-tested and coherent, this textbook teaches classical and web information retrieval, including web search and the related areas of text classification and text clustering from basic concepts. It gives an up-to-date treatment of all aspects of the design and implementation of systems for gathering, indexing, and searching documents; methods for evaluating systems; and an introduction to the use of machine learning methods on text collections. All the important ideas are explained using examples and figures, making it perfect for introductory courses in information retrieval for advanced undergraduates and graduate students in computer science. Based on feedback from extensive classroom experience, the book has been carefully structured in order to make teaching more natural and effective. Slides and additional exercises (with solutions for lecturers) are also available through the book's supporting website to help course instructors prepare their lectures.
Utility of a Perfluorochemical Liquid for Pulmonary Diagnostic Imaging (1994)

The use of neat perfluorochemical liquid (PFC) as an alternative respiratory medium has gained increasing attention for assessment and treatment of the immature or injured lung. In vitro and in vivo plain film and computed tomographic (CT) studies were performed on small and large animals to evaluate the use of perfluorooctylbromide (perflubron) as a bronchographic contrast agent and to quantitate the distribution and elimination of this fluid from the lung following total liquid ventilation or during gas breathing after tracheal instillation of small quantities of this liquid. The results demonstrate the utility of a highly radiopaque PFC liquid in combination with diagnostic imaging techniques to visualize small airways anatomy, identify regional and gravity dependent differences in distribution/elimination of the fluid, ventilation, and track PFC liquid following therapeutic application.