gebhart/patrepeval huggingface dataset:
Selection of Measurement Locations for Experimental Modal Analysis (1994)

In this paper the task of selecting a set of measurement locations for use in an experimental modal analysis is investigated. Currently popular methods for choosing measurement locations are discussed and compared. The effect of both the number and the location of measurement points on the accuracy of the results is examined. Finally, a new approach for selecting the measurement positions is proposed. This method employs a multivariate functional approximation of modal data from a pretest finite element analysis to select an appropriate set of points. Examples arc presented to illustrate the accuracy and efficiency of this new method. In particular, for a given number of points, increased precision compared to Guyan reduction is noted in the higher frequency region. NOMENCLATURE ab,c,d E i,n,m T.(5) X.Y,Z 5m P u linear dimensions Elastic modulus indices Chebyshev polynomials spatial coordinates roots of Chebyshev polynomial mass density Poisson’s ratio INTRODUCTION The judicious choice of measurement (excitation and response) locations is critical for an accurate experimental modal analysis. A sufficient number of points must be chosen and properly located such that accurate modal data for all modes of interest arc obtained. Ao improper choice of measurement points can lead to modes being inaccurately measured or completely missed. At the same time, it is prudent to pick a small enough number so that the cost of the test and the time taken to perform it are reasonable. For some simple structures, an analyst may be able to make a good choice of measorement locations based on experience. However, for more complex structures it is desirable to have an automated approach available. Several authors have proposed automated methods for selecting accelerometer locations for use in modal tests. The first, and perhaps still the most popular method is static (Guyan) reductionI 11. Other approaches published include modal reduction[Z], hybrid reduction(31, and improved reduced system (IRS) reduction[4,5]. Another procedure which automatically selects accelerometer locations based on static flexibility shapes has been proposed by Flanigan and Botos[6]. Recently, Penny et. al.[7] compared a method for coordinate selection based on Guyan reduction method to the average driving point residue (ADPR) method used by LMS[S]. They conclude that the procedure based on Guyan reduction works best for
Anomalous increase in hot-carrier-induced threshold voltage shift in n-type drain extended metal-oxide-semiconductor transistors (2008)

Anomalous increase in positive threshold voltage shift (ΔVT) in n-type drain extended metal-oxide-semiconductor (DEMOS) transistors stressed under high drain voltage and gate voltage is observed. Charge pumping data and technology computer-aided-design simulations reveal that hot-electron injection and trapping in the gate oxide above channel region is responsible for ΔVT. Enhanced impact ionization rate resulted from the presence of large amount of negative oxide charge in channel region is identified to be the main mechanism for anomalous increase in ΔVT. From the results presented in this letter, hot-carrier-induced anomalous increase in ΔVT can become a serious reliability concern in DEMOS transistors.
<title>GaN-based violet-blue laser diodes</title> (2001)

High power GaN-based laser diodes (LDs) are very desirable for various applications such as optical storage systems. We have obtained GaN films of low dislocation density using epitaxial lateral overgrowth technique and the raised- pressure metalorganic chemical vapor deposition technique. Dislocation density of the improved GaN is about 10<SUP>7</SUP> cm<SUP>-2</SUP>. Optimized GaN-based LDs fabricated on the improved GaN films have operated up to 35 mW without any kink. The lifetime is more than 500 hours with a constant power of 20 mW at 25 degree(s)C under continuous wave conditions. Furthermore, we have introduced buried-ridge laser diode structure in order to control the optical transverse mode. The features of the far field patterns of LDs with AlGaN burying layers indicate their controllability.
Massively Parallel Conformal FDTD on a BlueGene Supercomputer (2007)

This paper presents modeling and simulation utilizing a parallel conformal finite-difference time-domain (Yu and Mittra, 2003) code developed at the Electromagnetic Communication Laboratory, Pennsylvania State University, on a massively parallel supercomputer. Parallelization, scalability, and application to the modeling of high-end server electrical interconnects are examined.
VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread (2016)

The specific role of VEGFA-induced permeability and vascular leakage in physiology and pathology has remained unclear. Here we show that VEGFA-induced vascular leakage depends on signalling initiated via the VEGFR2 phosphosite Y949, regulating dynamic c-Src and VE-cadherin phosphorylation. Abolished Y949 signalling in the mouse mutant Vegfr2(Y949F/Y949F) leads to VEGFA-resistant endothelial adherens junctions and a block in molecular extravasation. Vessels in Vegfr2(Y949F/Y949F) mice remain sensitive to inflammatory cytokines, and vascular morphology, blood pressure and flow parameters are normal. Tumour-bearing Vegfr2(Y949F/Y949F) mice display reduced vascular leakage and oedema, improved response to chemotherapy and, importantly, reduced metastatic spread. The inflammatory infiltration in the tumour micro-environment is unaffected. Blocking VEGFA-induced disassembly of endothelial junctions, thereby suppressing tumour oedema and metastatic spread, may be preferable to full vascular suppression in the treatment of certain cancer forms.
Use of ketoconazole to probe the pathogenetic importance of 1,25-dihydroxyvitamin D in absorptive hypercalciuria. (1992)

Ketoconazole was used to probe the pathogenetic importance of the serum 1,25-dihydroxyvitamin D [1,25-(OH)2D] concentration in 19 patients with well characterized absorptive hypercalciuria (AH). Patients were studied while receiving a constant metabolic diet before and after 2 weeks of ketoconazole administration (600 mg daily). Twelve of the patients were classified as ketoconazole responders, because in conjunction with a reduction of serum 1,25-(OH)2D from 113 +/- 36 to 70 +/- 26 pmol/L, intestinal 47Ca absorption decreased from 76.3 +/- 8.1% to 61.9 +/- 7.7%, and 24-h urinary Ca excretion declined from 7.6 +/- 1.4 to 5.7 +/- 1.1 mmol (P < 0.001 each). In these patients, intestinal 47Ca absorption was directly correlated with serum 1,25-(OH)2D levels and 24-h Ca excretion. In another group of 7 patients, termed ketoconazole nonresponders, despite reduction of 1,25-(OH)2D from 122 +/- 36 to 84 +/- 17 pmol/L (P = 0.015), there was no significant change in intestinal Ca absorption (76.0 +/- 8.2% to 72.1 +/- 10.6%) or 24-h urinary Ca excretion (7.3 +/- 1.3 to 7.2 +/- 1.0 mmol). In these patients, neither intestinal Ca absorption nor urinary Ca excretion was correlated with serum 1,25-(OH)2D levels. It, thus, appears that AH is a heterogeneous disorder comprised of both vitamin D-dependent and vitamin D-independent subsets. Although useful to probe the pathogenesis of AH, chronic treatment with ketoconazole is not recommended because of its generalized effects in inhibiting steroid synthesis.
Femtosecond-laser–induced modifications in Co/Pt multilayers studied with tabletop resonant magnetic scattering (2015)

We characterize the magnetic domain structure of Co/Pt multilayer fi lms on length scales below one hundred nanometers using resonant magnetic scattering and magnetic force microscopy. The extreme ultraviolet light for the scattering experiment is created by a laser- based high-order harmonic generation source. After illumination with intense ultrashort laser pulses, we observe pronounced changes in the magnetic structure and morphology. Furthermore, this study points out the importance of a detailed analysis of the different laser-induced modifications of a magnetic thin fi lm that influence the scattering patterns.
Propagation Characteristics of LN Photonic Wires (2012)

We investigate single-mode condition, coupling and bending characteristics of LiNbO3 (LN) photonic wires. We show bending losses of single-mode LN wires, allowable bend radius with negligible bending losses, and polarization-independent couplers.
Effects of titanium can electrode size and shock history on defibrillation electrode impedance (2002)

As the size of the implantable defibrillator can used as a defibrillation electrode decreases, changes in circuit impedance may occur for a given single-lead to can electrode system. In addition, increased electrode anodization due to the higher current densities at the can may cause increased electrode impedance. The relationship between can shadow area and circuit impedance was quantified in a saline tank system using 100 monophasic anodal shocks. Decreasing the shadow area of the can by a factor of 2 increased circuit impedance by 18%. The impedance of a plate electrode was 1.6/spl plusmn/0.3 /spl Omega/ higher than a can electrode with the same shadow area. Anodization of the titanium electrode after 100 shocks resulted in a 6% increase in circuit impedance for the smallest electrodes. Decreased can size resulted in an increase in circuit impedance and anodization, but the effect of increased circuit impedance on defibrillation efficacy is unknown.
Influence of Single Use and Combination of Reductants on the Size, Morphology and Growth Steps of Gold Nanoparticles in Colloidal Mixture (2012)

A comprehensive investigation on the formation mechanism of gold nanoparticles (AuNPs) in colloidal mixture obtained from the reduction of chloroauric acid (HAuCl4) solution using a single reducing agent (sodium citrate; process-I), (tannic acid; process-II), and a combination of two reducing agents (sodium citrate plus tannic acid; process-III) is reported. The growth steps at different time intervals during synthesis of colloidal AuNPs were monitored in situ and ex situ using various methods for all the three processes. The measurement of changes in the surface plasmon band position of colloidal AuNPs, along with dynamic light scattering results gave important information for the first assessing of particle size, shape and distribution. Besides, the size and morphological changes at different stages during different processes were also analyzed by transmission electron microscopy. The final Au particles of processes-I & II exhibited different shapes (spherical and nanowires) with particle size and nano wire diameter of 12 nm and 17 nm, respectively. Nevertheless, combination of two reductants (process-III) surprisingly leads to drastically reduced size (ca. 3 nm) with spherical morphology compared to their parent solutions with either of single reducing agent. This result clearly indicates that the combination of reductants has a significant influence on the particle size, morphology and formation mechanism.
Tau protein aggregation associated with SARS-CoV-2 main protease (2023)

Abstract The primary function of virus proteases is the proteolytic processing of the viral polyprotein. These enzymes can also cleave host cell proteins, which is important for viral pathogenicity, modulation of cellular processes, viral replication, the defeat of antiviral responses and modulation of the immune response. It is known that COVID-19 can influence multiple tissues or organs and that infection can damage the functionality of the brain in multiple ways. After COVID-19 infections, amyloid-β, neurogranin, tau and phosphorylated tau were detected extracellularly, implicating possible neurodegenerative processes. The present study describes the possible induction of protein aggregation by the SARS-CoV-2 3CL protease (3CL pro ) possibly relevant in neuropathology, such as aggregation of tau, alpha-synuclein and TPD-43. Further investigations demonstrated that tau was proteolytically cleaved by the viral protease 3CL and, consequently, generated aggregates. However, more evidence is needed to confirm that COVID-19 is able to trigger neurodegenerative diseases.
ArgBP2, a Multiple Src Homology 3 Domain-containing, Arg/Abl-interacting Protein, Is Phosphorylated in v-Abl-transformed Cells and Localized in Stress Fibers and Cardiocyte Z-disks (1997)

Arg and c-Abl represent the mammalian members of the Abelson family of protein-tyrosine kinases. A novel Arg/Abl-binding protein, ArgBP2, was isolated using a segment of the Arg COOH-terminal domain as bait in the yeast two-hybrid system. ArgBP2 contains three COOH-terminal Src homology 3 domains, a serine/threonine-rich domain, and several potential Abl phosphorylation sites. ArgBP2 associates with and is a substrate of Arg and v-Abl, and is phosphorylated on tyrosine in v-Abl-transformed cells. ArgBP2 is widely expressed in human tissues and extremely abundant in heart. In epithelial cells ArgBP2 is located in stress fibers and the nucleus, similar to the reported localization of c-Abl. In cardiac muscle cells ArgBP2 is located in the Z-disks of sarcomeres. These observations suggest that ArgBP2 functions as an adapter protein to assemble signaling complexes in stress fibers, and that ArgBP2 is a potential link between Abl family kinases and the actin cytoskeleton. In addition, the localization of ArgBP2 to Z-disks suggests that ArgBP2 may influence the contractile or elastic properties of cardiac sarcomeres and that the Z-disk is a target of signal transduction cascades.
Trend detection through temporal link analysis (2004)

Abstract Although time has been recognized as an important dimension in the co‐citation literature, to date it has not been incorporated into the analogous process of link analysis on the Web. In this paper, we discuss several aspects and uses of the time dimension in the context of Web information retrieval. We describe the ideal case—where search engines track and store temporal data for each of the pages in their repository, assigning timestamps to the hyperlinks embedded within the pages. We introduce several applications which benefit from the availability of such timestamps. To demonstrate our claims, we use a somewhat simplistic approach, which dates links by approximating the age of the page's content. We show that by using this crude measure alone it is possible to detect and expose significant events and trends. We predict that by using more robust methods for tracking modifications in the content of pages, search engines will be able to provide results that are more timely and better reflect current real‐life trends than those they provide today.
Multilingual Touchscreen Keyboard Design and Optimization (2012)

A keyboard design, once adopted, tends to have a longlasting and worldwide impact on daily user experience. There is a substantial body of research on touch-screen stylus keyboard optimization. Most of it has focused on English only. Applying rigorous mathematical optimization methods and addressing diacritic character design issues, this article expands this body of work to French, Spanish, German, and Chinese. More important and counter to the intuition that optimization by nature is necessarily specific to each language, this article demonstrates that it is possible to find common layouts that are highly optimized across multiple languages for stylus (or single finger) typing. We first obtained a layout that is highly optimized for both English and French input. We then obtained a layout that is optimized for English, French, Spanish, German, and Chinese pinyin simultaneously, reducing its stylus travel distance to about half of QWERTY's for all of the five languages. In comparison to QWERTY's 3.31, 3....
A New Series of Highly Potent Non-Peptide Bradykinin B2 Receptor Antagonists Incorporating the 4-Heteroarylquinoline Framework. Improvement of Aqueous Solubility and New Insights into Species Difference (2004)

Introduction of nitrogen-containing heteroaromatic groups at the 4-position of the quinoline moiety of our non-peptide B(2) receptor antagonists resulted in enhancing binding affinities for the human B(2) receptor and reducing binding affinities for the guinea pig one, providing new structural insights into species difference. A CoMFA study focused on the diversity of the quinoline moiety afforded correlative and predictive QSAR models of binding for the human B(2) receptor but not for the guinea pig one. A series of 4-(1-imidazolyl)quinoline derivatives could be dissolved in a 5% aqueous solution of citric acid up to a concentration of 10 mg/mL. A representative compound 48a inhibited the specific binding of [(3)H]BK to the cloned human B(2) receptor expressed in Chinese hamster ovary cells with an IC(50) value of 0.26 nM and significantly inhibited BK-induced bronchoconstriction in guinea pigs even at 1 microg/kg by intravenous administration.
Epidemiology, clinical picture and long‐term outcomes ofFIP1L1‐PDGFRA‐positive myeloid neoplasm with eosinophilia: Data from 151 patients (2020)

FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia (F/P+ MN-eo) is a rare disease: robust epidemiological data are lacking and reported issues are scarce, of low sample-size and limited follow-up. Imatinib mesylate (IM) is highly efficient but no predictive factor of relapse after discontinuation has yet been identified. One hundred and fifty-one patients with F/P+ MN-eo (143 males; mean age at diagnosis 49 years; mean annual incidence: 0.18 case per million population) were included in this retrospective nationwide study involving all French laboratories who perform the search of F/P fusion gene (study period: 2003-2019). The main organs involved included the spleen (44%), skin (32%), lungs (30%), heart (19%) and central nervous system (9%). Serum vitamin B12 and tryptase levels were elevated in 74/79 (94%) and 45/57 (79%) patients, respectively, and none of the 31 patients initially treated with corticosteroids achieved complete hematologic remission. All 148 (98%) IM-treated patients achieved complete hematologic and molecular (when tested, n = 84) responses. Forty-six patients eventually discontinued IM, among whom 20 (57%) relapsed. In multivariate analysis, time to IM initiation (continuous HR: 1,01 [0.99-1,03]; P = .05) and duration of IM treatment (continuous HR: 0,97 [0,95-0,99]; P = .004) were independent factors of relapse after discontinuation of IM. After a mean follow-up of 80 (56) months, the 1, 5- and 10-year overall survival rates in IM-treated patients were 99%, 95% and 84% respectively. In F/P+ MN-eo, prompt initiation of IM and longer treatment durations may prevent relapses after discontinuation of IM.
Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of SARS‐associated coronavirus (2006)

SARS-associated coronavirus was identified as the etiological agent of severe acute respiratory syndrome and a large virus pool was identified in wild animals. Virus generates drug resistance through fast mutagenesis and escapes antiviral treatment. siRNAs targeting different genes would be an alternative for overcoming drug resistance. Here, we report effective siRNAs targeting structural genes (i.e., spike, envelope, membrane, and nucleocapsid) and their antiviral kinetics. We also showed the synergistic effects of two siRNAs targeting different functional genes at a very low dose. Our findings may pave a way to develop cost effective siRNA agents for antiviral therapy in the future.
P‐60: High Edge Strength Glass for Mobile Devices (2015)

A new evaluation method of the “Edge Impact Test” has been developed. Breakage of cover glass from the edge is enabled to evaluate quantitatively by this method. It is found that resistance to edge impact damage has a correlation with the CT of glass, and a high CS is more effective to improve resistance to the edge impact damage than deep DOL.
Waste heat recovery system including a mechanism for collection, detection and removal of non-condensable gas (2023)

The disclosure describes a non-condensable gas collection, detection, and removal system for a WHR system that helps to maintain cycle efficiency of the WHR system across the life of an engine system associated with the WHR system. A storage volume is configured to collect non-condensable gas received from the working fluid circuit, and a release valve is configured to selectively release non-condensable gas contained within the storage volume.
Predispositional genome sequencing in healthy adults: design, participant characteristics, and early outcomes of the PeopleSeq Consortium (2019)

Healthy individuals who underwent predispositional sequencing expressed some concern around privacy prior to pursuing sequencing, but were enthusiastic about their experience and not distressed by their results. While reporting value in their health-related results, few participants reported making medical or lifestyle changes.
Maximally Reliable Markov Chains Under Energy Constraints (2009)

Signal-to-noise ratios in physical systems can be significantly degraded if the outputs of the systems are highly variable. Biological processes for which highly stereotyped signal generations are necessary features appear to have reduced their signal variabilities by employing multiple processing steps. To better understand why this multistep cascade structure might be desirable, we prove that the reliability of a signal generated by a multistate system with no memory (i.e., a Markov chain) is maximal if and only if the system topology is such that the process steps irreversibly through each state, with transition rates chosen such that an equal fraction of the total signal is generated in each state. Furthermore, our result indicates that by increasing the number of states, it is possible to arbitrarily increase the reliability of the system. In a physical system, however, an energy cost is associated with maintaining irreversible transitions, and this cost increases with the number of such transitions (i.e., the number of states). Thus, an infinite-length chain, which would be perfectly reliable, is infeasible. To model the effects of energy demands on the maximally reliable solution, we numerically optimize the topology under two distinct energy functions that penalize either irreversible transitions or incommunicability between states, respectively. In both cases, the solutions are essentially irreversible linear chains, but with upper bounds on the number of states set by the amount of available energy. We therefore conclude that a physical system for which signal reliability is important should employ a linear architecture, with the number of states (and thus the reliability) determined by the intrinsic energy constraints of the system.
Recent developments in IBD and the B7 family of costimulatory molecules. (2009)

The cells and tissues of the intestinal tract are subjected to a constant onslaught of antigenic challenge from both beneficial and harmful pathogens. Despite this constant stimulation, the host is able to maintain a relatively stable environment, often referred to as 'a controlled state of inflammation'. In patients with chronic inflammatory bowel disease, this controlled state of inflammation is lost. The cause of this loss of control is not fully understood, but there is emerging research interest in positive and negative costimulatory pathways as potential targets for modulating the dysregulation. This review describes the B7 and B7-like butyrophilin families of costimulatory molecules, with an emphasis on the role of costimulation in intestinal inflammation.