gebhart/patrepeval huggingface dataset:
Information Flow in Disaster Management Systems (2010)

Collaborations between organizations in the public sector, e.g., fire brigades, polices, military units, is often done via liaison officers. A liaison officer liaises between two organizations by providing a single point of contact and ensuring the efficient communication and coordination of their activities. Usually an organization embeds a liaison officer in another organization to provide face-to-face coordination. Liaison officers demand special requirements to the security mechanism of the IT infrastructure of the organization that act as host for a liaison officer. This holds, in particular, for Disaster Management Information Systems (DMIS). Such systems need, on the one hand, to support various ways of communication in a flexible and ad hoc manner. On the other hand, these systems need to protect, by law, the leakage of sensitive data. In this paper, we present a novel mechanism, based on role-based access control (RBAC), for supporting the flexible and secure information exchange between organizations using liaison officers. Our mechanism enables liaison officers to decide on their own authority which information they wants share with their home organizations while allowing the host organization to limit the access of liaisons officers to their system in a fine-grained manner.
Fabricating retinal pigment epithelial cell sheets derived from human induced pluripotent stem cells in an automated closed culture system for regenerative medicine (2019)

Regenerative medicine has received a lot of attention as a novel strategy for injuries and diseases that are difficult to cure using current techniques. Cell production, which is vital for regenerative medicine, has undergone remarkable progress via breakthroughs in developmental biology and tissue engineering; currently, cell production requires numerous experimental operators performing manual, small-scale cell cultures. Other major obstacles for cell production and regenerative medicine include the variable quality of products based on the experimental procedure, the skills of operators, the level of labor required for production, and costs. Technological developments are required to overcome this, including automation instead of manual culture. Age-related macular regeneration (AMD) is a refractory ocular disease that causes severe deterioration in central vision due to senescence in the retinal pigment epithelium (RPE). Recently, we performed an autologous transplantation of induced pluripotent stem (iPS) cell-derived RPE cell sheets and started clinical research on allografts from RPE cell suspensions differentiated from iPS cells. The use of regenerative therapies for AMD using iPS cell-derived RPE is expected to become more widespread. In the present study, human iPS cell-derived RPE cells were cultured to form RPE cell sheets using equipment with a closed culture module. The quality of the automated cultured RPE cell sheets was confirmed by comparing their morphological and biological properties with those of manually generated RPE cell sheets. As a result, machine-cultured RPE sheets displayed the same quality as manually cultured RPE sheets, showing that iPS cell-derived RPE cell sheets were successfully cultured by an automated process.
Spectrum Segmentation Techniques for Edge-RAN Decoding in Telemetry-Based IoT Networks (2021)

The possible fields of application for small sensor nodes are tremendous and still growing fast. Concepts like the Internet of Things (IoT), Smart City or Industry 4.0 adopt wireless sensor networks for environmental interaction or metering purposes. As they commonly operate in license-exempt frequency bands, telemetry transmissions of sensors are subject to strong interferences and possible shadowing. Especially in the scope of Low Power Wide Area (LPWA) communications, this scenario results in high computational effort and complexity for the receiver side to perceive the signals of interest. Therefore, this paper investigates means to an adequate segmentation of receive spectra for a partial spectrum exchange between base stations of telemetry-based IoT sensor networks. The distinct interchange of in-phase and quadrature (IQ) data could facilitate stream combining techniques to mask out interferences amongst other approaches. This shall improve decoding rates even under severe operation conditions and simultaneously limit the required data volume. We refer to this approach of a reception network as Edge-RAN (Random Access Network). To cope with the high data rates and still enable a base station collaboration, especially in wirelessly connected receiver mesh networks, different filter bank techniques and block transforms are examined, to divide telemetry spectra into distinct frequency sub-channels. Operational constraints for the spectral decomposition are given and different filter methodologies are introduced. Finally, suitable metrics are established. These metrics shall assess the performance of the presented spectrum segmentation schemes for the purpose of a selective partial interchange between sensor network receivers.
Super-adiabatic flame temperatures in premixed methane-oxygen flames (2015)

Oxy-fuel combustion differs significantly from conventional air combustion. The absence of nitrogen leads to higher flame temperatures and larger concentration of major species as well as intermediate species. In the present work, freely propagating methane-oxygen flames were numerically calculated using a 1D model from lean to rich conditions in order to investigate the appearance of super-adiabatic flame temperatures (SAFT). The calculations were performed for equivalence ratios of 0.5 &lt; Φ &lt; 3.0 with an increment of 0.1, different inlet temperatures from 300 K to 700 K and a pressure range of 0.1 MPa to 1 MPa. Additionally, selected results were investigated with different detailed chemical reaction mechanisms. The results showed that the maximum flame temperature exceeds the equilibrium temperature for equivalence ratios Φ &gt; 0.9. Two different regimes were identified, where SAFT phenomenon appears. The first regime was found in slightly rich conditions (1.0 &lt; Φ &lt; 2.1), whereas the second regime occurred in ultra-rich regime (Φ &gt; 2.1). A first maximum of temperature difference is observed at an equivalence ratio of Φ = 1.5. Approximately 120 K to 180 K higher temperatures than the equilibrium ones at standard inlet conditions are locally observed, depending on the applied reaction mechanism. The first maximum at Φ = 1.5 correlates with the maximum concentration of the Hradical, which plays a key role in the first SAFT regime. A minimum over-temperature of 50 K was identified at an equivalence ratio of Φ = 2.1. By significantly increasing the equivalence ratio, the maximum flame temperature exceeded the equilibrium up to almost 400 K at Φ = 3.0 in the second SAFT regime. An increased preheating temperature enhanced the occurrence of SAFT in the first regime and degraded it in the second regime. Elevated pressure leads to the opposite effects with decreased SAFT in the first and increased SAFT in the second regime.
Modèles de RI fondés sur l'information. (2010)

RÉSUMÉ. Dans une premier temps, nous présentons dans cet article une vue analytique des contraintes heuristiques récemment proposées pour les fonctions d'ordonnancement (retrieval function): ces caractérisations permettent ainsi de tester simplement si un modèle de recherche d'information (RI) respecte ces contraintes ou non. De plus, nous examinons un certain nombre de résultats empiriques sur les distributions de fréquences de mots et le rôle central joué par le phénomène de rafale, pour lequel nous proposons une définition formelle. Nous introduisons ensuite une nouvelle famille de modèles probabilistes pour la RI, fondée sur la notion d'infor- mation. Lorsque la loi de probabilité sous-jacente est capable de modéliser le phénomène de rafale, alors le modèle devient naturellement valide au sens des contraintes heuristiques. La distribution log-logistique est présentée dans ce contexte et les expériences, menées sur trois collections différentes, illustrent le comportement adéquat de ce modèle; il surpasse Okapi BM25 et les modèles de langues, avec lissage de Jelinek-Mercer ou de Dirichlet, à la fois pour la précision moyenne et la précision en tête de liste, fournit de meilleurs résultats que les mo- dèles DFR (Divergence from Randomness) en précision moyenne et des résultats similaires sur la précision en tête de liste, tout en simplifiant ces modèles.
Tunable Magnetic Properties of (Gd,Ce)2O2S Oxysulfide Nanoparticles (2019)

Abstract Invited for the cover of this issue is Sophie Carenco from Sorbonne Université, Paris, France. The cover image shows the synthesis and magnetic properties of the (Gd,Ce) 2 O 2 S oxysulfide nanoparticles.
Comparative evaluation of soft-switching, bidirectional, isolated AC/DC converter topologies (2012)

For realizing bidirectional and isolated AC/DC converters, soft-switching techniques/topologies seem to be a favourable choice as they enable a further loss and volume reduction of the system. Contrary to the traditional dual-stage approach, using a power factor corrector (PFC) stage in series with a DC/DC isolation stage, we showed recently that the same functionality can be achieved under full soft-switching operation using a single-stage dual active bridge (DAB) AC/DC converter. This paper investigates the performance of this single-stage approach by comparing it with a state-of-the-art conventional dual-stage concept (both soft-switching converters), where a bidirectional interleaved triangular current mode (TCM) PFC rectifier was chosen in combination with a DAB DC/DC converter. The advantages and drawbacks of each concept are discussed in detail, focusing on the impact of the utilized semiconductor technology and silicon area on the converter efficiency. Furthermore, a comprehensive comparison of power density is allowed by the analytical models that correlate the component losses with their respective volume.
Experimental validation of equilibria in fuel cells with dead-ended anodes (2013)

This paper investigates the nitrogen blanketing front during the dead-ended anode (DEA) operation of a PEM fuel cell. It is found that the dynamic evolution of nitrogen accumulation in the DEA of a PEM fuel cell eventually arrives to a steady-state, which suggests the existence of equilibrium. We use a multi-component model of the two-phase, one-dimensional (along-channel) system to analyze this phenomenon. Specifically, the model is first verified with experimental observations, and then utilized to show the evolution toward equilibrium. The full order model is reduced to a second-order partial differential equation (PDE) with one state, which can be used to predict and analyze the observed steady state DEA behavior. The parametric study is performed focusing on the influence of the cathode pressure on the existence of equilibrium in the DEA condition.
ChemInform Abstract: A Facile Synthesis of Dopamine‐4‐sulfate. (1984)

Abstract Auf den im Formelschema dargestellten Wegen werden die Dopaminsulfate (VII) und (X) hergestellt.
Highly-scalable disruptive reading scheme for Gb-scale SPRAM and beyond (2010)

We propose a disruptive reading and restoring schemes for high-density SPRAM. The proposed scheme uses the feature that, with a desired error rate, TMR device doesn't switch its magnetization of free layer in a specific period of large current pulse. The restoring operation is performed to ensure the storing data. As a result, keeping the good scalability of spin-transfer torque writing toward Gb-scale and beyond, high speed reading with read-disturbance-free operation can be achieved. This operation also enables the SPRAM to accept the DDRx-SDRAM compatible operation.
Substrate-embedded and flip-chip-bonded photodetector polymer-based optical interconnects: analysis, design, and performance (2003)

The performance of three optoelectronic structures incorporating substrate-embedded InP-based inverted metal-semiconductor-metal photodetectors and/or volume holographic gratings are analyzed and compared at the primary optical communication wavelengths. These structures, in conjunction with optical-quality polymer layers, can be easily integrated into silicon microelectronic substrates for the purpose of implementing potentially low-cost high-data-rate chip-level or substrate-level optical interconnects. The structures are as follows: a) an evanescent-coupling architecture with a substrate-embedded photodetector, b) a volume-holographic-grating coupler architecture with a substrate-embedded photodetector, and c) a volume-holographic-grating coupler architecture with a flip-chip-bonded photodetector. It is found that the primary characteristic of the evanescent coupling architectures is the efficient performance for both TE and TM polarizations with the disadvantage of exponentially decreasing efficiency with increasing separation between the waveguide film layer and the photodetector layer. On the other hand, the primary characteristic of the volume holographic grating architectures is the possibility of wavelength and polarization selectivity and their independence on the separation between the photodetector layer and the waveguide. Comparison of the analysis with experimental results is also included in the case of the evanescent coupling into a substrate-embedded photodetector.
Tables S1 and S2 from Frequent Nonrandom Activation of Germ-Line Genes in Human Cancer (2023)

Tables S1 and S2 from Frequent Nonrandom Activation of Germ-Line Genes in Human Cancer
Changes in Friction and Electrical Contact Resistance on Electroplated Gold Alloy Films Aged in Silicone Oils. (2007)

Abstract not provided.
Expanded Poly(tetrafluoroethylene) Blood Vessel Grafts with Embedded Reactive Oxygen Species (ROS)-Responsive Antithrombogenic Drug for Elimination of Thrombosis (2020)

Treatment of cardiovascular diseases suffers from the lack of transplantable small-diameter blood vessel (SDBV) grafts that can prohibit/eliminate thrombosis. Although expanded poly(tetrafluoroethylene) (ePTFE) has the potential to be used for SDBV grafts, recurrence of thrombus remains the biggest challenge. In this study, a reactive oxygen species (ROS)-responsive antithrombogenic drug synthesis and a bulk coating process were employed to fabricate functional ePTFE grafts capable of prohibiting/eliminating blood clots. The synthesized drug that would release antiplatelet ethyl salicylate (ESA), in responding to ROS, was dissolved in a polycaprolactone (PCL) solution, followed by a bulk coating of the as-fabricated ePTFE grafts with the PCL/drug solution. Nuclear magnetic resonance (NMR) spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and atomic force microscopy (AFM) were employed to investigate and confirm the synthesis and presence of the ROS-responsive drug in the ePTFE grafts. The ESA release functions were demonstrated via the drug-release profile and dynamic anticoagulation tests. The biocompatibility of the ROS-responsive ePTFE grafts was demonstrated via lactate dehydrogenase (LDH) cytotoxicity assays, live and dead cell assays, cell morphology, and cell-graft interactions. The ROS-responsive, antithrombogenic ePTFE grafts provide a feasible way for maintaining long-term patency, potentially solving a critical challenge in SDBV applications.
Ubiquitin‐activating enzyme (UBA1) is required for sperm capacitation, acrosomal exocytosis and sperm–egg coat penetration during porcine fertilization (2011)

Protein ubiquitination is a stable, covalent post-translational modification that alters protein activity and/or targets proteins for proteolysis by the 26S proteasome. The E1-type ubiquitin-activating enzyme (UBA1) is responsible for ubiquitin activation, the initial step of ubiquitin-protein ligation. Proteasomal proteolysis of ubiquitinated spermatozoa and oocyte proteins occurs during mammalian fertilization, particularly at the site of sperm acrosome contact with oocyte zona pellucida. However, it is not clear whether the substrates are solely proteins ubiquitinated during gametogenesis or if de novo ubiquitination also occurs during fertilization supported by ubiquitin-activating and -conjugating enzymes present in the sperm acrosome. Along this line of inquiry, UBA1 was detected in boar sperm-acrosomal extracts by Western blotting (WB). Immunofluorescence revealed accumulation of UBA1 in the nuclei of spermatogonia, spermatocytes and spermatids, and in the acrosomal caps of round and elongating spermatids. Thiol ester assays utilizing biotinylated ubiquitin and isolated sperm acrosomes confirmed the enzymatic activity of the resident UBA1. A specific UBA1 inhibitor, PYR-41, altered the remodelling of the outer acrosomal membrane (OAM) during sperm capacitation, monitored using flow cytometry of fluorescein isothiocyanate-conjugated peanut agglutinin (FITC-PNA). Although viable and motile, the spermatozoa capacitated in the presence of PYR-41, showed significantly reduced fertilization rates during in vitro fertilization (IVF; p < 0.05). Similarly, the fertilization rate was lowered by the addition of PYR-41 directly into fertilization medium during IVF. In WB, high Mr bands, suggestive of protein ubiquitination, were detected in non-capacitated spermatozoa by antibodies against ubiquitin; WB with anti-phosphotyrosine antibodies and antibodies against acrosomal proteins SPINK2 (acrosin inhibitor) and AQN1 (spermadhesin) revealed that the capacitation-induced modification of those proteins was altered by PYR-41. In summary, it appears that de novo protein ubiquitination involving UBA1 contributes to sperm capacitation and acrosomal function during fertilization.
Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis (2005)

Although the concept of a leukemic stem cell system has recently been well accepted, its nature and the underlying molecular mechanisms remain obscure. Constitutive activation of signal transducers and activators of transcription 3 (STAT3) and STAT5 is frequently detected in various hematopoietic tumors. To evaluate their role in normal and leukemic stem cells, we took advantage of constitutively active STAT mutants to activate STAT signaling selectively in hematopoietic stem cells (HSCs). Activation of STAT5 in CD34- c-Kit+ Sca-1+ lineage marker- (CD34- KSL) HSCs led to a drastic expansion of multipotential progenitors and promoted HSC self-renewal ex vivo. In sharp contrast, STAT3 was demonstrated to be dispensable for the HSC maintenance in vivo, and its activation facilitated lineage commitment of HSCs in vitro. In a mouse model of myeloproliferative disease (MPD), sustained STAT5 activation in CD34- KSL HSCs but not in CD34+ KSL multipotential progenitors induced fatal MPD, indicating that the capacity of STAT5 to promote self-renewal of hematopoietic stem cells is crucial to MPD development. Our findings collectively establish a specific role for STAT5 in self-renewal of normal as well as leukemic stem cells.
A single stage 54V to 1.8V multi-phase cascaded buck voltage regulator module (2015)

This paper proposes a new design approach to the conventional two stages solution to convert the 48-60V low voltage bus to the 1-1.8V point of load (PoL) voltage for microprocessors in large telecoms server farms. The core idea is to stack or cascade the buck voltage regulator module (VRM) input voltage in series and connect their output in parallel. This single stage multi-phase cascaded buck (MCB) VRM has a large degree of design freedom depending on the load requirements. A 150W 6-phase MCB (two 3 phase modules in parallel) achieved a maximum efficiency of 91.3% in simulation. This paper also presents the results of a demonstrator of the same circuit which achieved a measured peak efficiency of 90.1%.
Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis (2020)

[This corrects the article DOI: 10.3389/fnmol.2019.00262.].
Fabrication of Minimally-Invasive Patch Type Glucose Sensors (2013)

A fine tube type glucose sensor, which has a sensing region at the inside wall of fine tube tip, was prepared and applied for minimally invasive glucose monitoring. The enzyme glucose oxidase was immobilized on the platinum surface located in the tube by the combination of electrodeposition and electropolymerization of o-phenylenediamine. Amperometric responses of the prepared electrodes to glucose were measured at a potential of 0.60 V (vs Ag/AgCl). The tube type electrode showed good response with good linear relationship up to the glucose concentration of 22.4 mM, which was actually higher than general sensor without outer film for permeability restriction. This may be due to it unique sensor structure.
The Lutonium: a sub-nanojoule asynchronous 8051 microcontroller (2003)

We describe the Lutonium, an asynchronous 8051 microcontroller designed for low Et/sup 2/. In 0.18 /spl mu/m CMOS, at nominal 1.8 V, we expect a performance of 0.5 nJ per instruction at 200 MIPS. At 0.5 V, we expect 4 MIPS and 40 pJ/instruction, corresponding to 25,000 MIPS/Watt. We describe the structure of a fine-grain pipeline optimized for Et/sup 2/ efficiency, some of the peripherals implementation, and the advantages of an asynchronous implementation of a deep-sleep mechanism.
Major Secretory Mucin Expression in Chronic Sinusitis (2005)

Mucins may be used as markers for assessment of disease severity and may also help as prognostic indicators following medical or surgical treatment.
An Edge Alignment-Based Orientation Selection Method for Neutron Tomography (2023)

Neutron computed tomography (nCT) is a 3D char-acterization technique used to image the internal morphology or chemical composition of samples in biology and materials sciences. A typical workflow involves placing the sample in the path of a neutron beam, acquiring projection data at a predefined set of orientations, and processing the resulting data using an analytic reconstruction algorithm. Typical nCT scans require hours to days to complete and are then processed using conventional filtered back-projection (FBP), which performs poorly with sparse views or noisy data. Hence, the main methods in order to reduce overall acquisition time are the use of an improved sampling strategy combined with the use of advanced reconstruction methods such as model-based iterative reconstruction (MBIR). In this paper, we propose an adaptive orientation selection method in which an MBIR reconstruction on previously-acquired measurements is used to define an objective function on orientations that balances a data-fitting term promoting edge alignment and a regularization term promoting orientation diversity. Using simulated and experimental data, we demonstrate that our method produces high-quality reconstructions using significantly fewer total measurements than the conventional approach.
GASTROLITHIASIS IN PREHENSILE-TAILED PORCUPINES (COENDOU PREHENSILIS): NINE CASES AND PATHOGENESIS OF STONE FORMATION (2014)

Gastrolithiasis was diagnosed in nine prehensile-tailed (PT) porcupines (Coendou prehensilis) housed at six zoologic institutions in the United States and Canada. Affected animals were either asymptomatic or had clinical signs, including weight loss, diarrhea, and depression. Abdominal palpation was adequate for diagnosis in all six antemortem cases, and radiographs confirmed a soft tissue density mass effect produced by the concretion. These gastroliths were all successfully surgically removed. Recurrence of gastrolith formation was common and occurred in four of the cases. Three cases were diagnosed postmortem, with the gastrolith causing gastric perforation in one case. Gastroliths from four cases were identified by mass spectrometry as bile acid precipitates consisting of the insoluble acid form of endogenous glycine-conjugated bile acids.
Supplementary Figure 1 from A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors (2023)

&lt;p&gt;Schematic of lentiviral and retroviral expression plasmids.&lt;/p&gt;