gebhart/patrepeval huggingface dataset:
Cloning of Rat and Human Inducible Penile Nitric Oxide Synthase Application for Gene Therapy of Erectile Dysfunction (1998)

No AccessJournal of UrologyUrological Survey: Abstracts: Sexual Function and Dysfunction1 May 1998Cloning of Rat and Human Inducible Penile Nitric Oxide Synthase Application for Gene Therapy of Erectile Dysfunction H. Garban, D. Marquez, T. Magee, J. Moody, T. Rajavashisth, J.A. Rodriguez, A. Hung, D. Vernet, J. Rajfer, and N.F. Gonzalez-Cadavid H. GarbanH. Garban More articles by this author , D. MarquezD. Marquez More articles by this author , T. MageeT. Magee More articles by this author , J. MoodyJ. Moody More articles by this author , T. RajavashisthT. Rajavashisth More articles by this author , J.A. RodriguezJ.A. Rodriguez More articles by this author , A. HungA. Hung More articles by this author , D. VernetD. Vernet More articles by this author , J. RajferJ. Rajfer More articles by this author , and N.F. Gonzalez-CadavidN.F. Gonzalez-Cadavid More articles by this author View All Author Informationhttps://doi.org/10.1097/00005392-199805000-00133AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Cloning of Rat and Human Inducible Penile Nitric Oxide Synthase Application for Gene Therapy of Erectile Dysfunction." The Journal of Urology, 159(5), p. 1778 Department of Surgery, Division of Urology, and Department of Medicine, Division of Endocrinology, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance, California.© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 159Issue 5May 1998Page: 1778 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information H. Garban More articles by this author D. Marquez More articles by this author T. Magee More articles by this author J. Moody More articles by this author T. Rajavashisth More articles by this author J.A. Rodriguez More articles by this author A. Hung More articles by this author D. Vernet More articles by this author J. Rajfer More articles by this author N.F. Gonzalez-Cadavid More articles by this author Expand All Advertisement PDF DownloadLoading ...
Quantitative Measurements of Codeine and Fentanyl on a Surface-Enhanced Raman-Active Pad (2019)

The USA is in the midst of an opioid crisis that included over 60,000 overdose fatalities in 2017, mostly unintentional. This is due to excessive use of prescription opioids and the use of very strong synthetic opioids, such as fentanyl, mixed with illicit street drugs. The ability to rapidly determine if people or packages entering the country have or contain drugs could reduce their availability, and thereby decrease the use of illicit drugs. In an effort to address this problem, we have been investigating the ability of surface-enhanced Raman spectroscopy to detect trace amounts of opioids on clothing and packages. Here, we report the measurement of codeine and fentanyl at 100 ng/mL for 5 min on a pad impregnated with gold colloids, as well as a preliminary measurement of 500 pg of fentanyl on a glass surface using one of these pads. The calculated limit of detection for this measurement was 40 pg. This data strongly suggests that these pads, used with portable Raman analyzers, would be invaluable to airport security, drug raids, crime scenes, and forensic analysis.
Precise optical modeling for LED lighting verified by cross correlation in the midfield region (2006)

A novel LED modeling algorithm for precise three-dimensional light pattern simulation is proposed and demonstrated. We propose to use normalized cross correlation to verify the validity of the simulation in one-dimensional intensity patterns as well as two-dimensional irradiance patterns in various midfield distances and to provide feedback to achieve a successful model. The model is demonstrated to obtain an average of 99% in normalized cross correlation between the simulation light pattern and experimental measurement for a truncated inverse pyramid LED.
Emission, LBO and Combustion Dynamic Characterization of Several Alternative Fuels (2005)

Regulations are becoming increasingly stringent regarding gas turbine emissions. In addition fuel costs are at record highs. Power plant operators are exploring all alternatives for reducing operational cost. Refinery offgas represents an attractive cost reduction measure if one could burn it in the gas turbine. Hydrogen and methane are often the main components of such offgas. In an attempt to define the potential for an LEC-III® (Power Systems Mfg., LLC. Low Emission Combustor) performance with such an offgas, rig testing has been successfully carried out with several alternative fuels. Small quantities of hydrogen blended with natural gas and burned in specific zones of the combustor allowed emissions levels of sub 2ppm NOx and sub 9ppm CO to be demonstrated at full base load engine operating conditions on the test rig. Based upon rig to engine benchmarking these same emissions levels should be realized upon the full engine.
Vedolizumab as Induction and Maintenance Therapy for Crohnʼs Disease in Patients Naïve to or Who Have Failed Tumor Necrosis Factor Antagonist Therapy (2016)

Vedolizumab had increased efficacy over placebo in CD patients irrespective of TNF-α antagonist treatment history. Overall, rates of response and remission were numerically higher in patients receiving vedolizumab as a first biologic than in patients who had experienced TNF failure.
M17 human neuroblastoma cell as a cell model for investigation of Botulinum Neurotoxin A activity and evaluation of BoNT/A specific antibody (2008)

Since BoNTs are potential biothreat agents, efforts are being made to develop therapeutic countermeasures for which sensitive in vitro models are required to evaluate the efficacy of potential therapeutic agents. In this report, we tested human neuroblastoma cell lines for their susceptibility to BoNT toxicity and demonstrated the application of these cells to measure the neutralising activity of a BoNT-specific antibody. We demonstrated that SK-N-BE(2)M17 cells are highly sensitive to BoNT/A and /C intoxication and can be used as a cell-based assay to investigate the molecular mechanism of BoNT/A intoxication and to quantitate the neutralising activity of antibodies. [Received 26 October 2007; Accepted 12 December 2007]
A New Approach to the Synthesis of 4-Hydroxyethylsulfonylstyrene (2009)

A new, more environmentally benign route to hydroxyethylsulfonylstyrene has been developed, starting from 4-bromobenzenethiol, involving a solventless thioether formation, water-based perborate oxidation, and Suzuki−Miyaura cross coupling with a vinylborate reagent.
Effect of Presilanization Filler Decontamination on Aesthetics and Degradation Resistance of Resin Composites. (2002)

Filler-matrix coupling determines, to a large extent, the mechanical strength and clinical longevity of dental composites. The aim of this study was to examine how far a methodology to decontaminate filler prior to silanization may improve aesthetic performance in addition to physico-mechanical properties such as degradation resistance. It was reported that filler particles are surrounded and wrapped by a film that consists of multiple layers of silane molecules. X-ray photoelectron spectroscopy, however, revealed that silanization of filler particles largely depended upon siloxane bridge (Si-O-Si) formation between the silica surface and the silane molecule rather than on intermolecular bonding between adjacent silane molecules. In this study, we showed that filler decontamination resulted in a higher translucency, thereby providing a better aesthetic potential. In addition, experimental composites produced following presilanization decontamination of filler revealed a higher Vickers hardness value and a diametral tensile strength that was resistant to degradation by thermo-cycling.
Low power consumption integrated acousto-optic filter in domain inverted LiNbO_3 superlattice (2010)

We report on an integrated acousto-optic filter in domain inverted LiNbO3 using a coplanar electrode configuration, which can achieve complete optical switching at electrical powers as low as 50 mW. These values are more than one order of magnitude lower than previously reported results [Opt. Lett. 34, 3205 (2009)]. In order to design the low power consumption devices, we have calculated surface acoustic wave excitation, propagation and acousto-optic interaction in the domain inverted LiNbO3 superlattice using scalar approximation and FEM analysis. Results from both modeling techniques are in good agreement with the experiments, including direct measurement of the acoustic displacement using laser interferometry and acousto-optic performance.
Search for heavy particles decaying into top-quark pairs using lepton-plus-jets events in proton–proton collisions at $$\sqrt{s} = 13$$ s = 13 $$\text {TeV}$$ TeV with the ATLAS detector (2018)

A search for new heavy particles that decay into top-quark pairs is performed using data collected from proton-proton collisions at a centre-of-mass energy of 13 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mtext>TeV</mml:mtext></mml:math> by the ATLAS detector at the Large Hadron Collider. The integrated luminosity of the data sample is 36.1 fb <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow></mml:mrow> <mml:mrow><mml:mo>-</mml:mo> <mml:mn>1</mml:mn></mml:mrow> </mml:msup> </mml:math> . Events consistent with top-quark pair production are selected by requiring a single isolated charged lepton, missing transverse momentum and jet activity compatible with a hadronic top-quark decay. Jets identified as likely to contain <i>b</i>-hadrons are required to reduce the background from other Standard Model processes. The invariant mass spectrum of the candidate top-quark pairs is examined for local excesses above the background expectation. No significant deviations from the Standard Model predictions are found. Exclusion limits are set on the production cross-section times branching ratio for hypothetical <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mi>Z</mml:mi> <mml:mo>'</mml:mo></mml:msup> </mml:math> bosons, Kaluza-Kein gluons and Kaluza-Klein gravitons that decay into top-quark pairs.
Dose Estimation of Radiation Exposure from Hormesis Cosmetics (2008)

Cosmetics claiming hormesis effects are available through Internet. Although the hormesis effect is explained in each product of cosmetics, there is no explanation about the radiation source. The existence of the progeny nuclides of Th and U series (RI) was comfirmed by the γ-ray spectroscopy using a HPGe detector. The highest radioactivity densities were 68Bq/g of the Th-series included in the hormesis powder. Because the particles containing RI were of the size of 1-10 micrometer by observing and analyzing SEM-EDX, there is a risk of inhaling the powder to the deep into the lungs. Furthermore, as about 1% RI was dissolved in water, the uptake of the RI to the body would be possible. The highest value of the evaluation of uniform radiation exposure to some organs by the continuous usage for 10 years was 5.5mSv/y of the hormesis powder inhalation to the lung. Furthermore, the calculated quantity of the radioactivity of progeny of 222Rn deposited in the body after continuous use of the hormesis cream every day for one year becomes 24Bq. The possibility of accumulation of the radioactivity in the body from the hormesis cosmetics cannot be denied. The addition of the radioisotope to cosmetics is prohibited in some EU countries by the regulation. It's proposed in this paper that the legitimacy of the addition of the radioisotope should be seriously re-examined.
Database simplification for field prediction in urban environment [radiowave propagation] (2004)

The performance and the usability of deterministic field prediction tools for the urban environment is heavily limited by the high computing time, which depends exponentially on the size of the input urban database. A simple technique for urban database simplification, aimed at speeding up deterministic field prediction is presented in the paper. Such a technique, based on a sort of heuristic preprocessing of the city map, identifies the buildings which are 'likely' to have an impact on the multipath propagation mechanism taking place between the radio terminals, and discards the rest of the map. Using this pre-processing technique, the CPU time can be decreased by orders of magnitude in typical ray tracing prediction cases, while the accuracy of the results only marginally degrades, as shown in the results section of the paper.
Application of information theory to a three‐body coarse‐grained representation of proteins in the PDB: Insights into the structural and evolutionary roles of residues in protein structure (2014)

Knowledge-based methods for analyzing protein structures, such as statistical potentials, primarily consider the distances between pairs of bodies (atoms or groups of atoms). Considerations of several bodies simultaneously are generally used to characterize bonded structural elements or those in close contact with each other, but historically do not consider atoms that are not in direct contact with each other. In this report, we introduce an information-theoretic method for detecting and quantifying distance-dependent through-space multibody relationships between the sidechains of three residues. The technique introduced is capable of producing convergent and consistent results when applied to a sufficiently large database of randomly chosen, experimentally solved protein structures. The results of our study can be shown to reproduce established physico-chemical properties of residues as well as more recently discovered properties and interactions. These results offer insight into the numerous roles that residues play in protein structure, as well as relationships between residue function, protein structure, and evolution. The techniques and insights presented in this work should be useful in the future development of novel knowledge-based tools for the evaluation of protein structure.
Irreversibility of Pressure Induced Boron Speciation Change in Glass (2014)

It is known that the coordination number (CN) of atoms or ions in many materials increases through application of sufficiently high pressure. This also applies to glassy materials. In boron-containing glasses, trigonal BO3 units can be transformed into tetrahedral BO4 under pressure. However, one of the key questions is whether the pressure-quenched CN change in glass is reversible upon annealing below the ambient glass transition temperature (Tg). Here we address this issue by performing (11)B NMR measurements on a soda lime borate glass that has been pressure-quenched at ~0.6 GPa near Tg. The results show a remarkable phenomenon, i.e., upon annealing at 0.9Tg the pressure-induced change in CN remains unchanged, while the pressurised values of macroscopic properties such as density, refractive index, and hardness are relaxing. This suggests that the pressure-induced changes in macroscopic properties of soda lime borate glasses compressed up to ~0.6 GPa are not attributed to changes in the short-range order in the glass, but rather to changes in overall atomic packing density and medium-range structures.
Optimisation of Tetrahydroisoquinoline‐Based Chimeric Microtubule Disruptors (2014)

Tetrahydroisoquinoline (THIQ)-based "chimeric" microtubule disruptors were optimised through modification of the N-benzyl motif, in concert with changes at C3 and C7, resulting in the identification of compounds with improved in vitro antiproliferative activities (e.g. 15: GI50 20 nM in DU-145). The broad anticancer activity of these novel structures was confirmed in the NCI 60-cell line assay, with 12 e,f displaying MGM values in the 40 nM region. In addition, their profiles as inhibitors of tubulin polymerisation and colchicine binding to tubulin were confirmed. Compound 15, for example, inhibited tubulin polymerisation with an IC50 of 1.8 μM, close to that of the clinical drug combretastatin A-4, and also proved effective at blocking colchicine binding. Additionally, compound 20 b was identified as the only phenol in the series to date showing both better in vitro antiproliferative properties than its corresponding sulfamate and excellent antitubulin data (IC50=.6 μM). Compound 12 f was selected for in vivo evaluation at the NCI in the hollow fibre assay and showed very good activity and wide tissue distribution, illustrating the value of this template for further development.
Anti-brolucizumab immune response as one prerequisite for rare retinal vasculitis/retinal vascular occlusion adverse events (2023)

In October 2019, Novartis launched brolucizumab, a single-chain variable fragment molecule targeting vascular endothelial growth factor A, for the treatment of neovascular age-related macular degeneration. In 2020, rare cases of retinal vasculitis and/or retinal vascular occlusion (RV/RO) were reported, often during the first few months after treatment initiation, consistent with a possible immunologic pathobiology. This finding was inconsistent with preclinical studies in cynomolgus monkeys that demonstrated no drug-related intraocular inflammation, or RV/RO, despite the presence of preexisting and treatment-emergent antidrug antibodies (ADAs) in some animals. In this study, the immune response against brolucizumab in humans was assessed using samples from clinical trials and clinical practice. In the brolucizumab-naïve population, anti-brolucizumab ADA responses were detected before any treatment, which was supported by the finding that healthy donors can harbor brolucizumab-specific B cells. This suggested prior exposure of the immune system to proteins with structural similarity. Experiments on samples showed that naïve and brolucizumab-treated ADA-positive patients developed a class-switched, high-affinity immune response, with several linear epitopes being recognized by ADAs. Only patients with RV/RO showed a meaningful T cell response upon recall with brolucizumab. Further studies in cynomolgus monkeys preimmunized against brolucizumab with adjuvant followed by intravitreal brolucizumab challenge demonstrated that high ADA titers were required to generate ocular inflammation and vasculitis/vascular thrombosis, comparable to RV/RO in humans. Immunogenicity therefore seems to be a prerequisite to develop RV/RO. However, because only 2.1% of patients with ADA develop RV/RO, additional factors must play a role in the development of RV/RO.
ChemInform Abstract: NMR Based Quantum Information Processing: Achievements and Prospects (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Visual fields at different stages of diabetic retinopathy (1994)

Available studies on visual field disturbances in diabetic retinopathy have shown conflicting results, obtained with different and often non-comparable techniques. We have studied visual fields at different stages of diabetic retinopathy with modern sensitive computerized technique taking precautions to limit disturbing effects of random field variation and lack of perimetric experience. Sixty-three diabetic patients, insulin-dependent and non-insulin dependent, were each subject to three test sessions using the 30-2 full threshold program of the Humphrey perimeter. Retinopathy levels ranged from 10 to 65 in the ETDRS Final scale. In eyes without retinopathy or with very mild and mild disease (levels 10-35) mean deviation values exceeding the p < 5% level occurred in only 4% of eyes in trained sessions, and the number of test points with significantly reduced sensitivity did not exceed that expected in normal eyes. In moderate and moderately severe diabetic retinopathy (level 43-47) and in severe non-proliferative and proliferative retinopathy (levels 53-65) there was clear evidence of field loss, however, with significantly reduced mean deviation values in 44% of the eyes and 6.5% of tested points showing reproducible loss of sensitivity. Thus, there was no evidence of field loss in eyes with mild disease, but clear field defects in eyes with more advanced disease. Significantly reduced sensitivity was often correlated with retinal non-perfusion and there was seen a tendency towards more correlation in the midperiphery than paracentrally.
From Bare Metal Powders to Colloidally Stable TCO Dispersions and Transparent Nanoporous Conducting Metal Oxide Thin Films (2012)

A simple, green, robust, widely applicable, multi-gram and cost-effective ‘one-pot’ synthesis of aqueous dispersions of colloidally stable 3–6 nm TCO NPs using bare metal powder precursors is described, and their utilization for making TCO high surface area nanoporous films is also demonstrated, which speaks well for their usage in a wide range of possible processes and devices. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A Locus of the Gonadotropin-releasing Hormone Receptor That Differentiates Agonist and Antagonist Binding Sites (1995)

The decapeptide gonadotropin-releasing hormone controls reproductive function via interaction with a heptahelical G protein-coupled receptor. Because of molecular model of the receptor predicts that Lys121 in the third transmembrane helix contributes to the binding pocket, the function of this side chain was studied by site-directed mutagenesis. Substitution of Arg at this position preserved high affinity agonist binding, whereas Gln at this position reduced binding below the limits of detection. Leu and Asp at this locus abolished both binding and detectable signal transduction. The EC50 of concentration-response curves for coupling to phosphatidyl inositol hydrolysis obtained with the Gln121 receptor was more than 3 orders of magnitude higher than that obtained for the wild-type receptor. In order to determine whether the increased EC50 obtained with this mutant reflects an altered receptor affinity, the effect of decreases in wild-type receptor density on concentration-response curves was determined by irreversible antagonism. Progressively decreasing the concentration of the wild-type receptor increased the EC50 values obtained to a maximal level of 2.4 +/- 0.2 nM. Comparison of this value with the EC50 of 282 +/- 52 nM observed with the Gln121 receptor mutant indicates that the agonist affinity for this mutant is reduced more than 100-fold. In contrast, antagonist had comparable high affinities for the wild-type, Arg121, and Gln121 mutants. The results indicate that a charge-strengthened hydrogen bond donor is required at this locus for high affinity agonist binding but not for high affinity antagonist binding.
Small-Signal Model of the Two-Phase Interleaved Coupled-Inductor Boost Converter (2017)

A coupled-inductor dc-dc converter has several modes of operation in continuous-conduction mode (CCM) and discontinuous-conduction mode (DCM), and is quite complex. This paper presents the derivation of the complete small-signal model of a two-phase interleaved dc-dc boost converter utilizing a single-core coupled-inductor operating in both CCM and DCM. Several small-signal models are required to fully model the converter due to the complexity of the converter operating in DCM. The transfer functions are then derived from these small-signal models. The theoretical analysis is validated experimentally using frequency sweeps from a 1-kW prototype.