gebhart/patrepeval huggingface dataset:
Application-Based Coexistence of Different Waveforms on Non-orthogonal\n Multiple Access (2020)

The coexistence of different wireless communication systems such as LTE and\nWi-Fi by sharing the unlicensed band is well studied in the literature. In\nthese studies, various methods are proposed to support the coexistence of\nsystems, including listen-before-talk mechanism, joint user association and\nresource allocation. However, in this study, the coexistence of different\nwaveform structures in the same resource elements are studied under the theory\nof non-orthogonal multiple access. This study introduces a paradigm-shift on\nNOMA towards the application-centric waveform coexistence. Throughout the\npaper, the coexistence of different waveforms is explained with two specific\nuse cases, which are power-balanced NOMA and joint radar-sensing and\ncommunication with NOMA. In addition, some of the previous works in the\nliterature regarding non-orthogonal waveform coexistence are reviewed. However,\nthe concept is not limited to these use cases. With the rapid development of\nwireless technology, next-generation wireless systems are proposed to be\nflexible and hybrid, having different kinds of capabilities such as sensing,\nsecurity, intelligence, control, and computing. Therefore, the concept of\ndifferent waveforms' coexistence to meet these concerns are becoming impressive\nfor researchers.\n
Factors driving the activity of commercial titanium dioxide powders towards gas phase photocatalytic oxidation of acetaldehyde (2012)

The photocatalytic activity of two commercial titanium dioxide powders (Cristal Global, Millennium PC500 and Evonik, P25) is compared towards acetaldehyde degradation in the gas phase. In contrast to the extensive literature available, we found a higher activity for the PC500 than for the P25 coating. Here, we present a comprehensive characterization of the bulk and surface properties of both powders. Our comparison shows that the material properties that dominate the overall photocatalytic activity in gas phase differ from those required for the photodegradation of water-borne pollutants.
Direct Diode Pumped Ti:sapphire Lasers and Amplifiers (2018)

Direct diode-pumped Ti:sapphire laser amplifiers use fiber-coupled laser diodes as pump beam sources. The pump beam may be polarized or non-polarized. Light at wavelengths below 527 nm may be used in cryogenic configurations. Multiple diode outputs may be polarization or spectrally combined.
Disruption of Growth Hormone Receptor in Adipocytes Improves Insulin Sensitivity and Lifespan in Mice (2022)

Growth hormone receptor knockout (GHRKO) mice have been used for 25 years to uncover some of the many actions of growth hormone (GH). Since they are extremely long-lived with enhanced insulin sensitivity and protected from multiple age-related diseases, they are often used to study healthy aging. To determine the effect that adipose tissue has on the GHRKO phenotype, our laboratory recently created and characterized adipocyte-specific GHRKO (AdGHRKO) mice, which have increased adiposity but appear healthy with enhanced insulin sensitivity. To test the hypothesis that removal of GH action in adipocytes might partially replicate the increased lifespan and healthspan observed in global GHRKO mice, we assessed adiposity, cytokines/adipokines, glucose homeostasis, frailty, and lifespan in aging AdGHRKO mice of both sexes. Our results show that disrupting the GH receptor gene in adipocytes improved insulin sensitivity at advanced age and increased lifespan in male AdGHRKO mice. AdGHRKO mice also exhibited increased fat mass, reduced circulating levels of insulin, c-peptide, adiponectin, resistin, and improved frailty scores with increased grip strength at advanced ages. Comparison of published mean lifespan data from GHRKO mice to that from AdGHRKO and muscle-specific GHRKO mice suggests that approximately 23% of lifespan extension in male GHRKO is due to GHR disruption in adipocytes vs approximately 19% in muscle. Females benefited less from GHR disruption in these 2 tissues with approximately 19% and approximately 0%, respectively. These data indicate that removal of GH's action, even in a single tissue, is sufficient for observable health benefits that promote long-term health, reduce frailty, and increase longevity.
Controlled proteolysis of EGF receptors: Evidence for transmembrane distribution of the EGF binding and phosphate acceptor sites (1980)

A small quantity of the 125I-EGF (epidermal growth factor) bound specifically to EGF receptors on the human epidermoid carcinoma cell line A431 associates covalently. The direct linkage complex formed migrates during gel electrophoresis as a single diffuse band of MW = 160,000-170,000. In contrast, direct linkage complexes of 160,000, 145,000, and 115,000 daltons are formed when EGF is incubated with membranes isolated from these cells; these arise from EGF receptor modification during membrane isolation. None of these modifications affected the affinity of the EGF binding site for 125I-EGF. The electrophoretic mobilities of the MW = 160,000 and 145,000 direct linkage complexes were similar to those of the major 32Pi-labeled products of the EGF-stimulated phosphorylation reaction described by Carpenter et al [Nature 276:409-410, 1978], indicating that proteolytic fragments of EGF receptors are the major phosphate acceptors in this reaction. EGF receptors on intact A431 cells accepted phosphate effectively from gamma-32Pi-ATP only when the cells were permeabilized with lysolecithin. This shows that the EGF binding and phosphate acceptor sites lie on opposing faces of the membrane. When the 145,000 dalton form of receptor is labeled with EGF or 32Pi and the labeled peptides subjects to tryptic hydrolysis under identical conditions, all phosphate is lost from high molecular weight products under conditions where the EGF-receptor covalent complex is converted largely to a 115,000 dalton form. This suggests that the phosphate acceptor site lies on the cytoplasmic side of the membrane on a region of receptor extending 30,000 daltons from the 115,000 dalton fragment containing the EGF binding site.
Quantitative Analysis of Peripheral Benzodiazepine Receptor in the Human Brain Using PET with11C-AC-5216 (2009)

Regional distribution of (11)C-AC-5216 was in good agreement with previous PET studies of PBRs in the human brain. BP(ND) is more appropriate for estimating (11)C-AC-5216 binding than is V(T) because of the interindividual variation of K(1)/k(2). (11)C-AC-5216 is a promising PET ligand for quantifying PBR in the human brain.
Data Poisoning Attacks against Differentially Private Recommender Systems (2020)

Recommender systems based on collaborative filtering are highly vulnerable to data poisoning attacks, where a determined attacker injects fake users with false user-item feedback, with an objective to either corrupt the recommender system or promote/demote a target set of items. Recently, differential privacy was explored as a defense technique against data poisoning attacks in the typical machine learning setting. In this paper, we study the effectiveness of differential privacy against such attacks on matrix factorization based collaborative filtering systems. Concretely, we conduct extensive experiments for evaluating robustness to injection of malicious user profiles by simulating common types of shilling attacks on real-world data and comparing the predictions of typical matrix factorization with differentially private matrix factorization.
TESTING OF STATE ROADSIDE SAFETY SYSTEMS. VOLUME XI: APPENDIX J - CRASH TESTING AND EVALUATION OF EXISTING GUARDRAIL SYSTEMS (1990)

The purpose of this study is to crash test and evaluate new or modified roadside safety hardware and, where necessary, redesign the devices to improve their impact performance. The three major areas addressed in this study are the impact performance of bridge railings, transitions from guardrails to bridge railings, and end treatments for guardrails and median barriers. This report presents the results of a series of crash tests conducted on existing guardrail systems with the 2000P test vehicle (i.e., a 2000-kg (4409-lb) pickup truck) in accordance with guidelines set forth in NCHRP Report 350. Results of the crash tests indicated that the cable (G1), box-beam (G3), W-beam, strong-wood-post (G4(2W)), and the modified thrie-beam guardrail systems performed satisfactorily under test level 3 conditions (i.e., at a nominal impact speed and angle of 100 km/h (62.2 mi/h) and 25 degrees). The W-beam, strong-steel post (G4(1S)), and the thrie-beam (G9) guardrail systems failed to perform satisfactorily under test level 3 conditions. The W-beam, weak-post (G2) guardrail system failed to perform satisfactorily under test level 3 conditions, but performed satisfactorily under test level 2 conditions (i.e., at a nominal impact speed and angle of 70 km/h (43.5 mi/h) and 25 degrees). This volume is the eleventh in a series of 14 volumes for the final report.
ChemInform Abstract: Growth of Carbon Nanotubes from Waste Blast Furnace Gases at Atmospheric Pressure. (2016)

Abstract In the lights of the steel industry contributing most to carbon emissions (CO 2 greenhouse gases), carbon nanotubes (CNTs) are grown by chemical vapor deposition (CVD) on steel substrates which act as catalysts for the CNT growth.
Fabrication of thermal microphotonic sensors and sensor arrays (2023)

A thermal microphotonic sensor is fabricated on a silicon substrate by etching an opening and a trench into the substrate, and then filling in the opening and trench with silicon oxide which can be deposited or formed by thermally oxidizing a portion of the silicon substrate surrounding the opening and trench. The silicon oxide forms a support post for an optical resonator which is subsequently formed from a layer of silicon nitride, and also forms a base for an optical waveguide formed from the silicon nitride layer. Part of the silicon substrate can be selectively etched away to elevate the waveguide and resonator. The thermal microphotonic sensor, which is useful to detect infrared radiation via a change in the evanescent coupling of light between the waveguide and resonator, can be formed as a single device or as an array.
Bow-tie slot antenna fed by CPW (1999)

A bow-tie slot antenna fed by CPW is introduced. It is designed to work in the Ku- band around 15.5 GHz. The proposed antenna is analysed both theoretically and experimentally. The presented results include the return loss and the radiation patterns. Two different geometries of the bow-tie antenna are presented and compared. The proposed antenna has several advantages such as a very large bandwidth, good control of its input impedance, and ease of fabrication. The proposed antenna has a dipole like radiation pattern which makes it suitable for mobile communication systems designed to work in the Ku- band.
Towards medical flexible instruments: a contribution to the study of flexible fluidic actuators (2010)

The medical community has expressed a need for flexible medical instruments. Hence, this work investigates the possibility to use "flexible fluidic actuators" to develop such flexible instruments. These actuators are driven by fluid, i.e. gas or liquid, and present a flexible structure, i.e. an elastically deformable and/or inflatable structure. Different aspects of the study of these actuators have been tackled in the present work: • A literature review of these actuators has been established. It has allowed to identify the different types of motion that these actuators can develop as well as the design principles underlying. This review can help to develop flexible instruments based on flexible fluidic actuators. • A test bench has been developed to characterize the flexible fluidic actuators. • A interesting measuring concept has been implemented and experimentally validated on a specific flexible fluidic actuator (the "Pneumatic Balloon Actuator", PBA). Ac- cording to this principle, the measurements of the pressure and of the volume of fluid supplied to the actuator allow to determine the displacement of the actuator and the force it develops. This means being able to determine the displacement of a flexible fluidic actuator and the force it develops without using a displacement sensor or a force sensor. This principle is interesting for medical applications inside the human body, for which measuring the force applied by the organs to the surgical tools remains a problem. The study of this principle paves the way for a lot of future works such as the implemen- tation and the testing of this principle on more complex structures or in a control loop in order to control the displacement of the actuator (or the force it develops) without using a displacement or a force sensor. • A 2D-model of the PBA has been established and has helped to better understand the physics underlying the behaviour of this actuator. • A miniaturization work has been performed on a particular kind of flexible fluidic actu- ator: the Pleated Pneumatic Artificial Muscle (PPAM). This miniaturization study has been made on this type of actuator because, according to theoretical models, minia- turized PPAMs, whose dimensions are small enough to be inserted into MIS medical instruments, could be able to develop the forces required to allow the instruments to perform most surgical actions. The achieved miniaturized muscles have a design similar to that of the third generation PPAMs developed at the VUB and present a total length of about 90 mm and an outer diameter at rest of about 15 mm. One of the developed miniaturized PPAMs has been pressurized at p = 1 bar and it was able to develop a pulling force F = 100 N while producing a contraction of 4 %. Propositions have been made regarding a further miniaturization of the muscles.
Surface micromachined crescent micropump (2010)

This study presents the design, fabrication, analysis and testing of a novel crescent micropump fabricated using surface micromachining technology. The pump utilizes a ring gear driven through teeth on its outer surface to drive the pumping mechanism through teeth on its inner surface. An analytical solution for the volumetric flow rate for the micropump agrees with the obtained experimental results.
Notice of Removal: Low loss delay lines based on suspended thin film of X-cut lithium niobate (2017)

Removed.
p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway (2015)

p21-activated kinases (Paks) have been shown to regulate cytoskeleton rearrangements, cell proliferation, attachment, and migration in a variety of cellular contexts, including endothelial cells. However, the role of endothelial Pak in embryo development has not been reported, and currently, there is no consensus on the endothelial function of individual Pak isoforms, in particular p21-activated kinase 2 (Pak2), the main Pak isoform expressed in endothelial cells. In this work, we employ genetic and molecular studies that show that Pak2, but not Pak1, is a critical mediator of development and maintenance of endothelial cell function. Endothelial depletion of Pak2 leads to early embryo lethality due to flawed blood vessel formation in the embryo body and yolk sac. In adult endothelial cells, Pak2 depletion leads to severe apoptosis and acute angiogenesis defects, and in adult mice, endothelial Pak2 deletion leads to increased vascular permeability. Furthermore, ubiquitous Pak2 deletion is lethal in adult mice. We show that many of these defects are mediated through a newly unveiled Pak2/Bmk1 pathway. Our results demonstrate that endothelial Pak2 is essential during embryogenesis and also for adult blood vessel maintenance, and they also pinpoint the Bmk1/Erk5 pathway as a critical mediator of endothelial Pak2 signaling.
Hereditary Hemochromatosis Restores the Virulence of Plague Vaccine Strains (2012)

Nonpigmented Yersinia pestis (pgm) strains are defective in scavenging host iron and have been used in live-attenuated vaccines to combat plague epidemics. Recently, a Y. pestis pgm strain was isolated from a researcher with hereditary hemochromatosis who died from laboratory-acquired plague. We used hemojuvelin-knockout (Hjv(-/-)) mice to examine whether iron-storage disease restores the virulence defects of nonpigmented Y. pestis. Unlike wild-type mice, Hjv(-/-) mice developed lethal plague when challenged with Y. pestis pgm strains. Immunization of Hjv(-/-) mice with a subunit vaccine that blocks Y. pestis type III secretion generated protection against plague. Thus, individuals with hereditary hemochromatosis may be protected with subunit vaccines but should not be exposed to live-attenuated plague vaccines.
The surface membrane antigen phenotype of human blood basophils (1994)

Basophils are effector cells of allergic reactions and express a unique profile of cellular antigens (Ag). Using a combined toluidine-blue/immunofluorescence staining method, we were able to study the cell membrane Ag phenotype of normal human blood basophils with monoclonal antibodies (mAbs) against established and novel CD antigens. According to previous findings, basophils express CD9 (p24), CD11a (LFA-1 alpha-chain), CD11b (C3biR), CD11c (CR4), CD13 (aminopeptidase N), CDw17 (lactosylceramide), CD18 (beta-chain of beta 2), CD25 (IL-2R alpha-chain), CD26 (dipeptidylpeptidase), CD31 (PECAM), CD35 (CR1), CD38 (T10), CD43 (leukosialin), CD44 (Pgp-1), CD45 (pan-leukocyte Ag), and CD63 (basophil activation Ag). Various novel CD Ags were detected on basophils, including membrane cofactor protein (MCP) (CD46), the N-linked glycan CD47, decay-accelerating factor (DAF) (CD55), membrane attack complex inhibitory factor (MACIF) (CD59), LFA-3 (CD58), ICAM-2 (CD 102), ICAM-3 (CD50), C5a receptor (CD88), MIC-2/E2 (CD99), and the interleukin-1 (IL-1) R type II (CD121b). These data provide further evidence that basophils express a unique profile of surface membrane receptors for cytokines and immunomodulating compounds, as well as adhesion molecules and surface glycolipids.
XML Query Optimization Using Path Indexes. (2004)

In this study, silver nanoparticles (AgNPs) were biosynthesised by using acidophilic actinobacterial SH11 strain isolated from pine forest soil. Isolate SH11 was identified based on 16S rRNA gene sequence to <i>Streptomyces kasugaensis</i> M338-M1<sup>T</sup> and <i>S</i>. <i>celluloflavus</i> NRRL B-2493<sup>T</sup> (99.8% similarity, both). Biosynthesised AgNPs were analysed by UV-visible spectroscopy, which revealed specific peak at <i>λ</i> = 420 nm. Transmission electron microscopy analyses showed polydispersed, spherical nanoparticles with a mean size of 13.2 nm, while Fourier transform infrared spectroscopy confirmed the presence of proteins as the capping agents over the surface of AgNPs. The zeta potential was found to be -16.6 mV, which indicated stability of AgNPs. The antibacterial activity of AgNPs from SH11 strain against gram-positive (<i>Staphylococcus aureus</i> and <i>Bacillus subtilis</i>) and gram-negative (<i>Escherichia coli</i>) bacteria was estimated using disc diffusion, minimum inhibitory concentration and live/dead analyses. The AgNPs showed the maximum antimicrobial activity against <i>E. coli</i>, followed by <i>B. subtilis</i> and <i>S. aureus</i>. Further, the synergistic effect of AgNPs in combination with commercial antibiotics (kanamycin, ampicillin, tetracycline) was also evaluated against bacterial isolates. The antimicrobial efficacy of antibiotics was found to be enhanced in the presence of AgNPs.
The role of the proteasome in autoimmunity (2000)

Type 1 diabetes is believed to be caused by T cell-mediated autoimmunity, with a prediabetic state characterized by the production of autoantibodies specific for proteins expressed by pancreatic beta cells. The non-obese diabetic (NOD) mouse is a spontaneous model of Type 1 diabetes with a strong genetic component that maps to the major histocompatibility complex (MHC) region of the genome. A specific proteasome defect has now been identified in NOD mouse lymphocytes that results from down-regulation of expression of the proteasome subunit LMP2, which is encoded by a gene in the MHC genomic region. This defect both prevents the proteolytic processing required for the production and activation of the transcription factor nuclear factor-kappaB (NF-kappaB), which plays an important role in immune and inflammatory responses, in addition to increasing the susceptibility of the affected cells to apoptosis induced by tumor necrosis factor-alpha (TNF-alpha). The proteasome dysfunction is both tissue- and developmental stage-specific and likely contributes to disease pathogenesis and tissue targeting.
Gonococcal penicillin‐binding protein 3 and the surface‐exposed 44kDa peptidoglycan‐binding protein appear to be the same molecule (1991)

The outer membrane of Neisseria gonorrhoeae contains a 44,000 dalton (44kDa) surface-exposed protein which has the reported ability to form covalent interactions with peptidoglycan (PG). This PG-binding outer-membrane protein (OMP) appears to be highly conserved since it has been detected in all isolates examined. It also appears to be invariant since its primary structure among strains gives evidence of being identical (Judd et al., 1991). While studying the interaction of gonococcal penicillin-binding proteins (PBPs) with human lysosomal cathepsin G, we noticed that the 44kDa PG-binding OMP exhibited certain properties similar to PBP3. In this study we sought to obtain biochemical evidence to ascertain whether these proteins were the same. We found that both proteins fractionated with other sarkosyl-insoluble OMPs and that they exhibited similar susceptibility to cleavage in situ by enzymatically active cathepsin G. Moreover, a purified preparation of the 44kDa OMP was found to covalently bind radiolabelled benzylpenicillin in vitro. Thus, the data presented herein suggest that the 44kDa PG-binding OMP and PBP3 are the same OMP.
Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia (2020)

Inotersen, a 2'-O-methoxyethyl (2'-MOE) phosphorothioate antisense oligonucleotide, reduced disease progression and improved quality of life in patients with hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) in the NEURO-TTR and NEURO-TTR open-label extension (OLE) trials. However, 300 mg/week inotersen treatment was associated with platelet count reductions in several patients. Mean platelet counts in patients in the NEURO-TTR-inotersen group remained ≥140 × 10<sup>9</sup>/L in 50% and ≥100 × 10<sup>9</sup>/L in 80% of the subjects. However, grade 4 thrombocytopenia (<25 × 10<sup>9</sup>/L) occurred in three subjects in NEURO-TTR trial, and one of these suffered a fatal intracranial hemorrhage. The two others were treated successfully with corticosteroids and discontinuation of inotersen. Investigations in a subset of subjects in NEURO-TTR (<i>n</i> = 17 placebo; <i>n</i> = 31 inotersen) and OLE (<i>n</i> = 33) trials ruled out direct myelotoxicity, consumptive coagulopathy, and heparin-induced thrombocytopenia. Antiplatelet immunoglobulin G (IgG) antibodies were detected at baseline in 5 of 31 (16%) inotersen-treated subjects in NEURO-TTR, 4 of whom eventually developed grade 1 or 2 thrombocytopenia while on the drug. In addition, 24 subjects in the same group developed treatment-emergent antiplatelet IgG antibodies, of which 2 developed grade 2, and 3 developed grade 4 thrombocytopenia. Antiplatelet IgG antibodies in two of the three grade 4 thrombocytopenia subjects targeted GPIIb/IIIa. Plasma cytokines previously implicated in immune dysregulation, such as interleukin (IL)-23 and a proliferation-inducing ligand (APRIL) were often above the normal range at baseline. Collectively, these findings suggest an underlying immunologic dysregulation predisposing some individuals to immune-mediated thrombocytopenia during inotersen treatment.