gebhart/patrepeval huggingface dataset:
Arene-metal complexes in organic synthesis: synthesis of acorenone and acorenone B (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTArene-metal complexes in organic synthesis: synthesis of acorenone and acorenone BM. F. Semmelhack and A. YamashitaCite this: J. Am. Chem. Soc. 1980, 102, 18, 5924–5926Publication Date (Print):August 1, 1980Publication History Published online1 May 2002Published inissue 1 August 1980https://pubs.acs.org/doi/10.1021/ja00538a046https://doi.org/10.1021/ja00538a046research-articleACS PublicationsRequest reuse permissionsArticle Views570Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Visualization of the disordered structure of Fe-Ni Invar alloys by reverse monte carlo calculations (2022)

Reverse Monte Carlo (RMC) calculation was performed to visualize the atomic arrangement in a disordered Fe 55 Ni 45 alloy, which is classified as an intermediate structure between the non-crystalline glass and crystalline structures. The optimized structure of the ferromagnetic phase at low pressures revealed that Fe and Ni atoms were displaced from a perfect fcc lattice to elongate the nearest neighboring Fe-Fe atomic pairs, therefore, Fe-Fe atomic pairs have longer bond length than Fe-Ni and Ni-Ni atomic pairs. Because the elongation becomes negligible during the pressure-induced destabilization of the ferromagnetic state, the elongation of Fe-Fe pairs is the atomic scale origin of the volume expansion due to a large magnetovolume effect. Compared with the atomic arrangement in the Fe 65 Ni 35 Invar alloy, a relationship between Fe-Fe atomic pairs, the Invar effect and elastic anomalies in the compression curve is elucidated.
Aspects of cancer immunotherapy (2003)

Cancer immunotherapy has traditionally undergone a 'revolution' every decade, from the use of Bacille Calmette-Guérin by scarification in the 1970s, to interleukin-2 therapies in the 1980s, and monoclonal antibody treatments in the early 1990s. Usually the early reports on the use of such agents were encouraging, but when more patients were studied in multiple centres, the initial promising results could not be confirmed. Now in a new century, we have more reagents and methods available than ever before - indeed, with such a plethora of reagents it is difficult to envisage them being fully and appropriately tested within the next decade, by which time there will be even more reagents to test. However, there have been three major advances which should lead to substantial progress in cancer immunotherapy: (1) the widespread use of genetic engineering, enabling identification of candidate vaccine proteins and manipulation of their sequences; (2) the production of antigens, antibodies and cytokines in large amounts by recombinant technologies, and (3) an understanding of the mode of presentation of peptides by major histocompatibility complex Class I and Class II molecules and their recognition by T cells. Despite these advances, there are major problems facing cancer immunotherapy, such as the ability of tumours to mutate and evade the immune system and the difficulty of precisely defining the interactions of effector cells in mediating 'rejection' or destruction of a tumour. There are clearly immunological similarities with diseases such as malaria and schistosomiasis, where the invading foreign organisms can use a variety of strategies to resist an elicited immune response. The failure to find a suitable vaccine for these diseases must lead to some pessimism for the development of immunotherapy for an autologous tumour. However, there are promising studies now in progress which should give an indication of the most important directions to follow. This review provides a commentary on aspects of cancer immunotherapy and in particular will deal with: (1) the selection of antigens as vaccine components; (2) the modes of presentation of antigens, particularly by major histocompatibility complex Class I molecules; and (3) new modes of delivery of vaccine immunogens.
MobiCom poster (2003)

article Share on MobiCom poster: reactive behavior in self-reconfiguring sensor networks Authors: Qun Li Dartmouth College Dartmouth CollegeView Profile , Ron Peterson Dartmouth College Dartmouth CollegeView Profile , Michael DeRosa Dartmouth College Dartmouth CollegeView Profile , Daniela Rus Dartmouth College Dartmouth CollegeView Profile Authors Info & Claims ACM SIGMOBILE Mobile Computing and Communications ReviewVolume 7Issue 1January 2003 pp 56–58https://doi.org/10.1145/881978.881995Online:01 January 2003Publication History 1citation72DownloadsMetricsTotal Citations1Total Downloads72Last 12 Months3Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
ChemInform Abstract: Diels‐Alder Cyclization of 2,8,10‐Undecatrienals as a Route to 1,2,3,4,4a,5,6,8a‐ Octahydronaphthalenes. (1986)

Abstract The 2,8,10‐undecatrienals (IIIc), (V) and (VII) undergo facile Diels‐Alder cyclization upon treatment with alkylaluminum chlorides in methylene Chloride at low temperature.
Simulation of bit error performance of FSK, BPSK, and pi /4 DQPSK in flat fading indoor radio channels using a measurement-based channel model (1991)

The results of a simulation study that provides insight into the simulation methodology and bit error rate (BER) performance of frequency-shift keying (FSK), binary phase-shift keying (BPSK), and pi /4 differential phase-shift keying ( pi /4 DQPSK) in flat fading channels inside open plan buildings are presented. A detailed measurement-based propagation channel model, SIRCIM (simulation of indoor radio channel impulse response models), which generates over 1000 closely spaced baseband equivalent complex impulse responses for a mobile radio operating at 1.3 GHz and traveling over a 1-m path, is used. The small-scale channel model, the communication system models used in the analysis and the methods used to predict BER are described. The channel simulator and the systems models have been thoroughly tested, and results from average instantaneous BER simulations are shown. The BER performances of the modulation techniques are presented. It is found that BPSK offers between a 2.8-dB and 3.0-dB improvement over pi /4 DQPSK, although the latter offers a 3-dB increase in capacity for a given spectrum allocation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Recent advances in EUV patterning in preparation towards high-NA EUV (2023)

High-NA EUV lithography is currently under development to keep up with device node scaling with smaller feature sizes. In this paper, the most recent advances in EUV patterning using metal oxide resists (MOR) and chemically amplified resists (CAR) are discussed. A newly developed resist development method (ESPERT™) was examined on MOR with 24 nm pitch line and space (L/S) patterns and 32 nm pitch pillars for preparation of high-NA EUV patterning. The patterning results showed improved sensitivity and pattern collapse margin. CAR contact hole patterning at 28 nm pitch was also examined by stochastic lithography simulation. The simulation results indicate that resist film thickness needs to be optimized for target pitches.
Design of a 10GHz clock distribution network using coupled standing-wave oscillators (2003)

In this paper, a global clock network that incorporates standing waves and coupled oscillators to distribute a high-frequency clock signal with low skew and low jitter is described. The key design issues involved in generating standing waves on a chip are discussed, including minimizing wire loss within an available technology. A standing-wave oscillator, a distributed oscillator that sustains ideal standing waves on lossy wires, is introduced. A clock grid architecture comprised of coupled, standing-wave oscillators and differential, low-swing clock buffers is presented. The measured results for a prototyped standing-wave clock grid operating at 10GHz and fabricated in a 0.18μm 6M CMOS logic process are presented. A technique is proposed for on-chip skew measurements with sub-picosecond precision.
Neurofilaments: Properties, Functions, and Regulation (2012)

Neuronal intermediate filaments are the most prominent cytoskeleton component of adult neurons in both central and peripheral nervous system. They include neurofilament triplet proteins, peripherin, α-internexin, nestin, and synemin. Although it was initially thought that neuronal intermediate filaments serve a primarily structural function, it has since been demonstrated that they constitute a dynamic network involved in neuronal differentiation, axon outgrowth, and regeneration. Finally, they emerged as a primary cause of some neurodegenerative diseases. Here, we focus on the properties, function, and regulation of neuronal intermediate filaments as well as their relationship to different neurodegenerative diseases.
Radiolabeled leukocyte imaging in inflammatory bowel disease: a prospective blinded evaluation. (2004)

We found radiolabeled leukocyte scintigraphy helpful in prospective, blinded assessments of patients with non-stricturizing or non-fistulizing forms of Crohn's disease. Scintigraphy may be more justified for reassessments rather than in making an initial diagnosis. The scans were of value in Crohn's disease but not for ulcerative colitis.
Alternative method to determine Specific Activity of <sup>177</sup>Lu by HPLC (2015)

the SA of (177)Lu is apparently often higher as stated by vendors in comparison to the experimentally determined actual values. For this reason, the SA of (177)Lu-DOTA-TATE and other Lu-DOTA-peptides could be increased accordingly.
Iron and Cobalt "Lacunar" Complexes as Dioxygen Carriers (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIron and Cobalt "Lacunar" Complexes as Dioxygen CarriersDaryle H. Busch and Nathaniel W. AlcockCite this: Chem. Rev. 1994, 94, 3, 585–623Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/cr00027a003https://doi.org/10.1021/cr00027a003research-articleACS PublicationsRequest reuse permissionsArticle Views1435Altmetric-Citations167LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Robust Query Processing (Dagstuhl Seminar 12321) (2012)

The 2012 Dagstuhl 12321 Workshop on Robust Query Processing, held from 5--10 August 2012, brought together researchers from both academia and industry to discuss various aspects of robustness in database management systems and ideas for future research. The Workshop was designed as a sequel to an earlier Workshop, Dagstuhl Workshop 10381, that studied a similar set of topics. In this article we summarize some of the main discussion topics of the 12321 Workshop, the results to date, and some open problems that remain.
High prevalence of mgrB-mediated colistin resistance among carbapenem-resistant Klebsiella pneumoniae is associated with biofilm formation, and can be overcome by colistin-EDTA combination therapy (2022)

The global prevalence of colistin-resistant Klebsiella pneumoniae (ColRkp) facilitated by chromosomal and plasmid-mediated Ara4N or PEtN-remodeled LPS alterations has steadily increased with increased colistin usage for treating carbapenem-resistant K. pneumoniae (CRkp). Our study demonstrated the rising trend of ColRkp showing extensively and pandrug-resistant characteristics among CRkp, with a prevalence of 28.5%, which was mediated by chromosomal mgrB, pmrB, or phoQ mutations (91.5%), and plasmid-mediated mcr-1.1, mcr-8.1, mcr-8.2 alone or in conjunction with R256G PmrB (8.5%). Several genetic alterations in mgrB (85.1%) with increased expressions of Ara4N-related phoPQ and pmrK were critical for establishing colistin resistance in our isolates. In this study, we discovered the significant associations between extensively drug-resistant bacteria (XDR) and pandrug-resistant bacteria (PDR) ColRkp in terms of moderate, weak or no biofilm-producing abilities, and altered expressions of virulence factors. These ColRkp would therefore be very challenging to treat, emphasizing for innovative therapy to combat these infections. Regardless of the underlying colistin-resistant mechanisms, colistin-EDTA combination therapy in this study produced potent synergistic effects in both in vitro and in vivo murine bacteremia, with no ColRkp regrowth and improved animal survival, implying the significance of colistin-EDTA combination therapy as systemic therapy for unlocking colistin resistance in ColRkp-associated bacteremia.
Percutaneous implantation of an aortic valve prosthesis (2005)

Recently, percutaneous aortic valve implantation has become an alternative technique to surgical valve replacement in patient at high risk for surgery. Our animal experimentation evaluated the technical feasibility of aortic valve replacement using a bovine pericardium valve sutured on a self-expandable stent in a sheep model. Precise implantation with satisfactory attachment on the adjacent tissues and absence of migration was obtain in 8 out of 14 animals. This study confirmed the feasibility of the endovascular implantation of a pericardium valve sutured on a self-expandable stent in a sheep model.
Tile-based Adaptive Streaming for Virtual Reality Video (2019)

The increasing popularity of head-mounted devices and 360° video cameras allows content providers to provide virtual reality (VR) video streaming over the Internet, using a two-dimensional representation of the immersive content combined with traditional HTTP adaptive streaming (HAS) techniques. However, since only a limited part of the video (i.e., the viewport) is watched by the user, the available bandwidth is not optimally used. Recent studies have shown the benefits of adaptive tile-based video streaming; rather than sending the whole 360° video at once, the video is cut into temporal segments and spatial tiles, each of which can be requested at a different quality level. This allows prioritization of viewable video content and thus results in an increased bandwidth utilization. Given the early stages of research, there are still a number of open challenges to unlock the full potential of adaptive tile-based VR streaming. The aim of this work is to provide an answer to several of these open research questions. Among others, we propose two tile-based rate adaptation heuristics for equirectangular VR video, which use the great-circle distance between the viewport center and the center of each of the tiles to decide upon the most appropriate quality representation. We also introduce a feedback loop in the quality decision process, which allows the client to revise prior decisions based on more recent information on the viewport location. Furthermore, we investigate the benefits of parallel TCP connections and the use of HTTP/2 as an application layer optimization. Through an extensive evaluation, we show that the proposed optimizations result in a significant improvement in terms of video quality (more than twice the time spent on the highest quality layer), compared to non-tiled HAS solutions.
High-resolution Brillouin gain spectroscopy in fused silica (1990)

We report what is to our knowledge the first high-resolution Brillouin gain spectrum in a solid. Resonances corresponding to longitudinal (compressional) and transverse (shear) acoustic waves in fused silica are observed with good resolution and a high signal-to-noise ratio. Absolute gain coefficients, linewidths, and Brillouin frequency shifts are measured. The agreement with previously measured values is good.
Multiparametric MRI to quantify disease and treatment response in mice with myeloproliferative neoplasms (2022)

Histopathology, the standard method to assess BM in hematologic malignancies such as myeloproliferative neoplasms (MPNs), suffers from notable limitations in both research and clinical settings. BM biopsies in patients fail to detect disease heterogeneity, may yield a nondiagnostic sample, and cannot be repeated frequently in clinical oncology. Endpoint histopathology precludes monitoring disease progression and response to therapy in the same mouse over time, missing likely variations among mice. To overcome these shortcomings, we used MRI to measure changes in cellularity, macromolecular constituents, and fat versus hematopoietic cells in BM using diffusion-weighted imaging (DWI), magnetization transfer, and chemical shift-encoded fat imaging. Combining metrics from these imaging parameters revealed dynamic alterations in BM following myeloablative radiation and transplantation. In a mouse MPLW515L BM transplant model of MPN, MRI detected effects of a JAK2 inhibitor, ruxolitinib, within 5 days of initiating treatment and identified differing kinetics of treatment responses in subregions of the tibia. Histopathology validated the MRI results for BM composition and heterogeneity. Anatomic MRI scans also showed reductions in spleen volume during treatment. These findings establish an innovative, clinically translatable MRI approach to quantify spatial and temporal changes in BM in MPN.
Proline-rich sequences that bind to Src homology 3 domains with individual specificities. (1995)

To study the binding specificity of Src homology 3 (SH3) domains, we have screened a mouse embryonic expression library for peptide fragments that interact with them. Several clones were identified that express fragments of proteins which, through proline-rich binding sites, exhibit differential binding specificity to various SH3 domains. Src-SH3-specific binding uses a sequence of 7 aa of the consensus RPLPXXP, in which the N-terminal arginine is very important. The SH3 domains of the Src-related kinases Fyn, Lyn, and Hck bind to this sequence with the same affinity as that of the Src SH3. In contrast, a quite different proline-rich sequence from the Btk protein kinase binds to the Fyn, Lyn, and Hck SH3 domains, but not to the Src SH3. Specific binding of the Abl SH3 requires a longer, more proline-rich sequence but no arginine. One clone that binds to both Src and Abl SH3 domains through a common site exhibits reversed binding orientation, in that an arginine indispensable for binding to all tested SH3 domains occurs at the C terminus. Another clone contains overlapping yet distinct Src and Abl SH3 binding sites. Binding to the SH3 domains is mediated by a common PXXP amino acid sequence motif present on all ligands, and specificity comes about from other interactions, often ones involving arginine. The rules governing in vivo usage of particular sites by particular SH3 domains are not clear, but one binding orientation may be more specific than another.
Pre-charge Method Using a Bi-directional Isolated DC-DC Converter (2019)

This paper proposes a capacitor pre-charge method using a bi-directional isolated DC-DC converter. This converter topology works as a phase-shifted full bridge DC-DC converter under forward direction of power conversion. In addition, this converter topology works as a current-fed converter under backward direction of power conversion and can operate in both the buck-mode and boost-mode. Then, a switching control method is presented for the voltage critical area of buck-boost. Appropriate input current control can be achieved by this switching control method in the voltage critical mode of buck-boost. Finally, the effectiveness of this pre-charge method is verified through an experiment on pre-charge using a 200V, 1000µF capacitor.
Lava dome cycles reveal rise and fall of magma column at Popocatépetl volcano (2023)

Lava domes exhibit highly unpredictable and hazardous behavior, which is why imaging their morphological evolution to decipher the underlying governing mechanisms remains a major challenge. Using high-resolution satellite radar imagery enhanced with deep-learning, we image the repetitive dome construction-subsidence cycles at Popocatépetl volcano (Mexico) with very high temporal and spatial resolution. We show that these cycles resemble gas-driven rise and fall of the upper magma column, where buoyant bubble-rich magma is extruded from the conduit (in ~hours-days), and successively drained back (in ~days-months) as magma degasses and crystallizes. These cycles are superimposed on a progressive decadal crater deepening, accompanied by heat and gas flux decrease, which could be partially explained by gas depletion within the magma plumbing system. Results reinforce the idea that gas retention and escape from the magma column play a key role in the short- and long-term morphological evolution of low-viscosity lava domes and their associated hazards.