gebhart/patrepeval huggingface dataset:
Progress in Inorganic Chemistry (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProgress in Inorganic ChemistryHarry B. GrayCite this: Inorg. Chem. 1963, 2, 5, 1084–1085Publication Date (Print):October 1, 1963Publication History Published online1 May 2002Published inissue 1 October 1963https://pubs.acs.org/doi/10.1021/ic50009a062https://doi.org/10.1021/ic50009a062research-articleACS PublicationsRequest reuse permissionsArticle Views118Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
(Deployable) reduction of multicast state with in-packet bloom filters (2013)

Abstract—Recent developments in networking technology have enabled massive media distribution in the Internet. However, bandwidth is still a limited resource and unicast-based media dis-tribution from a single source to multiple receivers is inefficient. Multicasting provides traffic replication closer to the receivers allowing more efficient data distribution. IP multicast can be used for distributing data streams in IP networks, but the bandwidth saving comes at the cost of increased state in the network routers. The amount of state is directly dependent on the number of multicast groups in use. In this paper, we show how in-packet Bloom filter (iBF) multicast can be used to reduce multicast state in the network. The deployment can be done gradually: during the migration phase, a single AS can replace IP multicast with the proposed iBF-based solution without affecting the rest of the network, and take advantage of the reduced state in its core routers. I.
Effects of Post-Deposition Annealing on the Electrical Properties of HfSiO Films Grown by Atomic Layer Deposition (2005)

Post-deposition annealing was investigated for hafnium silicate films deposited on Si substrates by atomic layer deposition. Annealing in NH 3 at 750°C incorporated 13 At.% nitrogen in hafnium silicate, and hysteresis significantly depended on film thickness. In contrast, annealing in N 2 at 950°C suppressed hysteresis and its dependence on the film thickness. In addition, effective mobility and positive bias temperature instability were improved by N 2 annealing of as-deposited hafnium silicate films. Finally, additional N 2 annealing following NH 3 annealing was effective to obtain highly dense hafnium silicate films with good mobility and optimized nitrogen incorporation.
An L band adaptive digital predistorter for power amplifiers using direct I-Q modem (2002)

This paper presents an L band experimental implementation of an adaptive digital predistorter (ADP) using direct I-Q modem for power amplifiers suitable to spectrally efficient mobile communication equipment. The linearizer, which is implemented in a digital signal processor (DSP) environment, performs the real time modeling (RTM) of the power amplifier to supply its AM-AM and AM-PM non-linearity characteristics. Experimental results demonstrate that the spectral spreading is reduced by 20 dB. The ADP achieve both power and spectral efficiencies and without the need for complex convergence algorithms and complex circuitry.
Purification and recognition of recombinant mouse P2X1 receptors expressed in a baculovirus system (2000)

Strategy, Management and Health Policy Venture Capital Enabling TechnologyPreclinical ResearchPreclinical Development Toxicology, Formulation Drug Delivery, PharmacokineticsClinical Development Phases I-III Regulatory, Quality, ManufacturingPostmarketing Phase IVThe hexahistidine-tagged mouse P2X(1) receptor (H-mP2X(1)R), an ATP-gated ion channel receptor, was expressed in a baculovirus system using the pAcHLT-B transfer vector containing a hexahistidine tag. Both widely used denaturing (8M urea) and nondenaturing (such as 1% Triton X-100) solubilization conditions were compared, resulting in about 30% of the P2X(1) receptors being solubilized (S1). However, at pH 13 most of the H-mP2X(1)R from the initially insoluble pellet fraction was solubilized (S2) and remained in the soluble fraction (S3) after dialyzing against a nondenaturing buffer. H-mP2X(1)Rs were purified sequentially through cobalt and ATP affinity columns. Receptors purified from S3 had higher purity than those from S1 (i.e., ~90% vs. ~75%). Circular dichroism spectra indicated identical protein secondary structures of the receptors from both sources. Autoradiographic data showed that the purified receptors from S3 had higher affinity for 8-azido-ATP-γ-(32)P than the receptors from S1. The binding of 8-azido-ATP-γ-(32)P to H-mP2X(1)R was inhibited by ATP-γ-S, α,β-me-ATP, and PPADS, but not by a nucleoside analog (N(6)-methyl-2'-deoxy-adenosine). In the presence of 2 mM Ca(2+) or Mg(2+) the binding was increased, but not when using a partially purified receptor fraction, in which unidentified proteins bound 8-azido-ATP-γ-(32)P or were phosphorylated at 4°C in the presence of 2 mM Mg(2+). These data suggest that the decrease in potency of ATP in the presence of Ca(2+) and Mg(2+), as observed in functional studies, is not due to a direct effect of the cations on the binding of ATP to the receptor. Both cyanogen bromide and hydroxylamine cleavage further confirmed the peptide structure of the purified H-mP2X(1)R. Autoradiographic analysis of the cleavage products showed that 8-azido-ATP-γ-(32)P was crosslinked to the carboxyl side of the extracellular domain of the receptor.
Price Level Dynamics in a Liquidity Trap (2003)

This paper studies the dynamic behavior of the general price level when the natural rate of interest declines substantially. Particular attention is paid to two constraints: the non-negativity constraint of nominal interest rates, and the government's intertemporal budget constraint. In a normal situation, nominal bond prices rise in response to the shock, which restores equilibrium. However, if the non-negativity constraint is binding, nominal bond prices cannot rise sufficiently. Equilibrium can then be restored only by a sufficient fall in the current price level. The required fall is greater when the maturity of government debt is shorter. To avoid deflation, the government must coordinate with the central bank by committing itself to reducing the current and future primary surplus.
Functional Significance of Fat Surrounding the Orbicularis Oculi Muscle (2010)

Correspondence: Gary E. Borodic, M.D., Harvard Medcial School, 1261 Furnace Brook Parkway, Quincy, MA, U.S.A. ([email protected])
Single Copies of Mutant KRAS and Mutant PIK3CA Cooperate in Immortalized Human Epithelial Cells to Induce Tumor Formation (2013)

The selective pressures leading to cancers with mutations in both KRAS and PIK3CA are unclear. Here, we show that somatic cell knockin of both KRAS G12V and oncogenic PIK3CA mutations in human breast epithelial cells results in cooperative activation of the phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways in vitro, and leads to tumor formation in immunocompromised mice. Xenografts from double-knockin cells retain single copies of mutant KRAS and PIK3CA, suggesting that tumor formation does not require increased copy number of either oncogene, and these results were also observed in human colorectal cancer specimens. Mechanistically, the cooperativity between mutant KRAS and PIK3CA is mediated in part by Ras/p110α binding, as inactivating point mutations within the Ras-binding domain of PIK3CA significantly abates pathway signaling. In addition, Pdk1 activation of the downstream effector p90RSK is also increased by the combined presence of mutant KRAS and PIK3CA. These results provide new insights into mutant KRAS function and its role in carcinogenesis.
Suzuki–Miyaura cross-coupling optimization enabled by automated feedback (2016)

An automated, droplet-flow microfluidic system explores and optimizes Pd-catalyzed Suzuki–Miyaura cross-coupling reactions. A smart optimal DoE-based algorithm is implemented to increase the turnover number and yield of the catalytic system considering both discrete variables—palladacycle and ligand—and continuous variables—temperature, time, and loading—simultaneously. The use of feedback allows for experiments to be run with catalysts and under conditions more likely to produce an optimum; consequently complex reaction optimizations are completed within 96 experiments. Response surfaces predicting reaction performance near the optima are generated and validated. From the screening results, shared attributes of successful precatalysts are identified, leading to improved understanding of the influence of ligand selection upon transmetalation and oxidative addition in the reaction mechanism. Dialkylbiarylphosphine, trialkylphosphine, and bidentate ligands are assessed.
Effectiveness of a fading emulator in evaluating the performance of MIMO systems by comparison with a propagation test (2010)

This paper presents a MIMO spatial fading emulator,<br/>used to represent a street microcell environment. The fading<br/>emulator can reproduce a multipath radio propagation<br/>environment with either a uniform or non-uniform angular<br/>power spectrum (APS) in the horizontal plane. In this paper, we<br/>used the emulator to measure the 2-by-2 MIMO characteristics<br/>of four handset arrays with two monopoles in a multipath<br/>environment with one spatial cluster of incoming waves. From<br/>our investigation, good agreement was obtained between the<br/>results from the emulator and data measured in a radio<br/>propagation test in a street microcell. This demonstrates that the<br/>emulator is effective in evaluating the MIMO performance in a<br/>multipath propagation environment.
Elemental Fluorine. Part 15. Selective Direct Fluorination of Quinoline Derivatives. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Polyphenolic Antioxidants Enhance IgE Production (2004)

Epidemiological data showed that total IgE and IL-4 levels in cigarette smokers were elevated, comparable to those in the asthmatics. The etiological agent(s) elevating IgE production are not clear. We evaluate whether tobacco polyphenols potentiate IgE production in a rodent model. Mice were fed with rutin or CGA in drinking water during antigen sensitization, followed by antigenic challenge i.p. in alum. CGA and rutin were also delivered in a bolus intraperitoneally or intranasally along with antigens during immunization. Antigen-specific IgE and IgG responses were measured. Enhancement of total IgE responses via i.p. and drinking routes can be achieved at concentrations as low as 0.1% CGA. Furthermore, IgG1 responses but not IgG2a and IgG2b were augmented, indicating a Th2 type of response by CGA. Moreover, both antigen-specific and serum IgE production can be achieved when CGA and antigenic challenges were delivered intranasally in the absence of alum. In contrast, nicotine does not enhance antigen-specific IgE production, and only marginally affects serum IgE levels. The more polarized Th2 development in CGA-treated mice may account for enhancement of both antigen-specific and total IgE responses. High levels of IL-4 but not IFN-gamma or IL-12, were observed in antigen-challenged mesenteric lymph nodes (MLN) cultures from CGA-treated mice. In contrast, significant levels of IL-4, IL-12, and IFN-gamma were observed in antigen-challenged cultures from nicotine-treated mice. This study shows that tobacco polyphenols, CGA and rutin potentiated IgE production in vivo. Polyphenolic antioxidants enhance Th2 development. We propose that IgE production and T cell dichotomy may be critically influenced by the redox microenvironment. Enhanced Th2 development and IgE production henceforth may counteract more severe Th1-mediated tissue damage triggered by environmental oxidative stress.
The effect of composition on mechanical properties of brushite cements (2013)

Due to a fast setting reaction, good biological properties, and easily available starting materials, there has been extensive research within the field of brushite cements as bone replacing material. However, the fast setting of brushite cement gives them intrinsically low mechanical properties due to the poor crystal compaction during setting. To improve this, many additives such as citric acid, pyrophosphates, and glycolic acid have been added to the cement paste to retard the crystal growth. Furthermore, the incorporation of a filler material could improve the mechanical properties when used in the correct amounts. In this study, the effect of the addition of the two retardants, disodium dihydrogen pyrophosphate and citric acid, together with the addition of β-TCP filler particles, on the mechanical properties of a brushite cement was investigated. The results showed that the addition of low amounts of a filler (up to 10%) can have large effects on the mechanical properties. Furthermore, the addition of citric acid to the liquid phase makes it possible to use lower liquid-to-powder ratios (L/P), which strongly affects the strength of the cements. The maximal compressive strength (41.8MPa) was found for a composition with a molar ratio of 45:55 between monocalcium phosphate monohydrate and beta-tricalcium phosphate, an L/P of 0.25ml/g and a citric acid concentration of 0.5M in the liquid phase.
HVAC load Disaggregation using Low-resolution Smart Meter Data (2019)

Traditional non-intrusive load monitoring (NILM) methods are effective for load disaggregation using high resolution smart meter data collected by power quality meters. However, smart meter data collected and stored by utilities are normally 15-, 30- or 60-minute in granularity, making most NILM methods ineffective. This paper presents a novel sequential energy disaggregation (SED) algorithm for extracting heating, ventilation, and air conditioning (HVAC) energy consumptions from residential and small commercial building loads using 30 min smart meter data. Large, infrequently-used loads are first detected and removed from the total building energy consumption. Then, base energy consumption curves, defined as the energy consumption without heating and cooling loads, are identified using the mild-day method. After that, the heating and cooling loads are extracted using an average value subtracting method. Simulation results with real data show that the proposed SED method is computationally efficient, simple to implement and robust in performance across different types of buildings.
P3‐029: PIVOTAL ROLES OF P62 AND SELECTIVE AUTOPHAGY IN NEURODEGENERATION REVEALED WITH TAUOPATHY MOUSE MODELS (2014)

The autophagic ubiquitin adaptor p62 mediates clearance of ubiquitinated cellular components through chaperone-assisted selective autophagy and package of ubiquitinated proteins into inclusion bodies as it self-assembles.As hyperphosphorylated tau in the brains of Alzheimer's disease and related tauopathies is ubiquitinated, p62 is presumed to be involved in the degradation and sequestration of this pathological form of tau. Here, we provide the first evidence that p62 acts protectively against neuronal death provoked by abnormal tau accumulation. In the P301S mutant human tau transgenic mouse (PS19), abundant accumulation of fibrillar tau inclusions resembling neurofibrillary tangles (NFTs) in human tauopathies are concurrent with gradual loss of neurons in the brainstem, while massive neuronal death prior to the formation of NFTs rapidly occurs in the hippocampus. We crossbred p62-knockout mice with PS19 mice to investigate roles of p62 in processing of abnormal tau. Deficiency in p62 alone did not induce overt neuropathologies, but accelerated neuronal loss in the hippocampus of P19 mice. Putatively neurotoxic tau oligomers were markedly increased in p62-deficient PS19 mice as assayed by immunoblotting and immunohistochemistry. Formation of granular inclusions packaging p62 and organelles observed in the PS19 hippocampus was nearly completely abolished by p62 deficiency. Sequestration of phosphorylated tau into neuronal somas was characteristic of the PS19 brainstem, and was in sharp contrast with diffuse somatodendritic and synaptic localization of phospho-tau in the hippocampus. Notably, this compartmentalization of phospho-tau in the brainstem was disrupted in p62-deficient PS19 mice, leading to neurodegeneration accompanied by inflammatory gliosis. Formation of NFT-like inclusions in the PS19 brainstem was partially suppressed by p62 deficiency. Finally, biochemical data indicated that insufficient reserve of authophagic capacity in the PS19 hippocampus may account for profound tau-induced neuronal loss in the hippocampus versus slow progression of neurodegeneration in the brainstem. Our findings have demonstrated that p62 protects neurons against tau-induced neurotoxicities by 1) eliminating phosphorylated tau oligomers primarily through selective autophagy; 2) sequestering abnormal tau species into neuronal somas; and 3) packaging damaged organelles tagged with ubiquitins.
The Minimally Invasive Interbody Selection Algorithm (MIISA) for Spinal Deformity (2019)

INTRODUCTION: Multiple MIS interbody fusion options have been utilized as MIS deformity surgery has become more prevalent. However, at this time there is little guidance for approach selection for MIS deformity surgery. The minimally invasive interbody selection algorithm (MIISA) was created to provide a framework for rational decision making for surgeons who are considering MIS deformity surgery. METHODS: A team of experienced spinal deformity surgeons developed the MIISA, incorporating the experience of a retrospective dataset from 223 MIS surgeries collected over a 5-yr period. The algorithm leads to one of 4 interbody approach options (including ALIF, ACR, LLIF, and TLIF) that allow either indirect or direct decompression of the neural elements, possibly restore disc space and foraminal height, and may restore lordosis. The algorithm was developed by fellowship-trained spine surgeons experienced with spinal deformity surgery and validated with the retrospective MIS database. RESULTS: A total of 11 surgeons completed 223 MIS deformity surgeries with 661 interbody devices. These cases were reviewed and the type of interbody approach used at each level from L1-S1 was recorded. The MIISA was created with substantial agreement. Surgeons preferred lateral approaches for L1-L2, L2-L3, and L3-L4. They preferred lateral approaches at L4-L5, but this was muted by more use of TLIF and ALIF at that level. They preferred TLIF to ALIF at L5-S1. The increase in segmental lordosis at L2-L3 was significantly greater with LLIF than TLIF. The increase in segmental lordosis at L4-L5 was significantly greater with ALIF than LLIF or TLIF. The increase in segmental lordosis at L5-S1 was greater with ALIF than TLIF. CONCLUSION: The use of the MIISA provides consistent and straightforward guidance for surgeons who are considering an MIS approach for the treatment of patients with adult spinal deformity. The application of this algorithm could provide a platform for surgeons to achieve the desired goals of surgery.
Beneficial Effects of La0.5Sr0.5CoO3 Coatings on Thin‐Film LiMn2O4 Cathodes for Lithium Ion Batteries (2023)

Abstract The severe capacity loss of spinel LiMn 2 O 4 (LMO) limits the utility of this otherwise promising lithium ion battery cathode material. One of the strategies to mitigate capacity fade is applying a coating on LMO particle surfaces. While this approach yields promising results, there is limited understanding of mechanisms whereby coatings improve LMO capacity retention. Herein, the effects of a new protective coating material, La 0.5 Sr 0.5 CoO 3 (LSCO), in a thin‐film battery geometry that is amenable to fundamental studies of electrode processes, are reported. RF sputtering deposition is used to produce high quality 25–100 nm LMO cathodes on Al 2 O 3 substrates with an intervening Pt/Ti back‐side contact layer. Cycling of the un‐coated cathodes results in capacity loss of 18% over 300 cycles. Adding a 2 nm LSCO layer reduces the capacity loss to 3%. While this may be due in part to reduced Mn dissolution, scanning transmission electron microscopy results indicate that the coating helps to preserve crystallinity and reduce lattice structure distortion due to inhibited formation of defect tetragonal spinel. Three‐electrode electrochemical impedance spectroscopy results reveal that the LSCO coating increases charge transfer and ohmic resistances, but the increases are generally too small to significantly impact cell performance even at high C‐rates.
Selective Lignin Modification Coupled with NMR Spectroscopy: A Method for Lignin Analysis (2005)

The objective of the present work was to study the reactions of various modifying reagents (NaBH{4}, MeOH, CH{2}N{2}, Me{2}SO{4}, DDQ) with native and technical lignins using high resolution correlation (HMQC and HSQC) and quantitative {13}C NMR spectroscopic techniques. The information obtained on pine MWL as a standard was applied to enhance the abilities of NMR spectroscopy in analysis of unidentified moieties in native and technical lignin using the modification reactions and their combinations as markers for the corresponding lignin structures. New information of on reactions of lignin with the reagents chosen, which in some cases were different from the reactions of model compounds, has been obtained. The reaction conditions were optimized to provide complete target reactions and minimize possible side reactions. This approach was very useful in assignment of unidentified moieties in native and technical lignin. In addition, it enhances the ability of NMR spectroscopy in quantification of various structures even in extensively investigated in pine MWL as well as in less investigated lignin preparations.
Il piano di marketing di fattoria di famiglia (2010)

Nascita del concetto di marketing. L’evoluzione dell’orientamento delle imprese al mercato: dalla produzione alla vendita al cliente. Piano di marketing. Fattoria di famiglia. Piano di marketing fattoria di famiglia.
Convex Kernelized Sorting (2021)

Kernelized sorting is a method for aligning objects across two domains by considering within-domain similarity, without a need to specify a cross-domain similarity measure. In this paper we present the Convex Kernelized Sorting method where, unlike in the previous approaches, the cross-domain object matching is formulated as a convex optimization problem, leading to simpler optimization and global optimum solution. Our method outputs soft alignments between objects, which can be used to rank the best matches for each object, or to visualize the object matching and verify the correct choice of the kernel. It also allows for computing hard one-to-one alignments by solving the resulting Linear Assignment Problem. Experiments on a number of cross-domain matching tasks show the strength of the proposed method, which consistently achieves higher accuracy than the existing methods.