gebhart/patrepeval huggingface dataset:
Seismic response of slender MDOF structures with self‐centering base shear and moment mechanisms (2023)

Abstract As the amplification of seismic force demands due to higher‐mode effects on tall buildings is increasingly recognized as a design challenge, a number of high‐performance systems have been proposed to limit such effects through combined base shear‐limiting and moment‐limiting dual mechanisms. To better understand the influence of these dual base systems on the overall seismic behavior of tall buildings, this paper presents a study on the seismic response of Multi‐Degree‐of‐Freedom (MDOF) systems incorporating combined base shear‐limiting and moment‐limiting mechanisms. For an MDOF system with a given initial period and base strength level, the base shear‐limiting mechanism is defined by a shear strength factor, an inelastic stiffness parameter, and an energy‐dissipation parameter, while the base moment‐limiting mechanism is defined by a moment strength factor. To determine the influence of these parameters on the overall seismic responses of MDOF structures, a comprehensive parametric study was conducted, and the results were presented and discussed in terms of base displacement and rotation demands, seismic force demand amplification at the base and along the height, peak floor acceleration, peak roof drift, and absorbed energy. The numerical modeling methodology used in the parametric study was validated against 200 small‐scale shaking table tests of a scaled MDOF specimen with a base shear and moment dual‐mechanism system and was used to model MDOF structures that are representative of tall buildings with initial periods ranging from 1.0 to 10 s and having various base‐mechanism properties. The parametric study was then conducted using an ensemble of 20 Ground Motions (GM) scaled to three code‐specified seismic hazard levels for Los Angeles, California. The results of this study can be used to facilitate the design of base shear and moment dual‐mechanism systems for mitigating higher‐mode effects and enhancing the seismic resilience of tall buildings.
Similarity in Neuronal Firing Regimes across Mammalian Species (2016)

By analyzing neuronal spike trains recorded from mice, rats, cats, and monkeys, we found that different brain regions have intrinsically different firing regimes that are more similar in homologous areas across species than across areas in one species. Because different regions in the brain are specialized for different functions, the present finding suggests that the different activity regimes of neurons are important for supporting different functions, so that appropriate neuronal codes can be used for different modalities.
Amaze: A Multiplayer Computer Game (1985)

Amaze relies solely on the V kernel for point-to-point communication. The game's techniques could work in a general class of distributed applications.
RNA fusions involving CD28 are rare in peripheral T-cell lymphomas and concentrate mainly in those derived from follicular helper T cells (2018)

International audience
Molecular recognition in the P2Y14 receptor: Probing the structurally permissive terminal sugar moiety of uridine-5′-diphosphoglucose (2020)

The P2Y14 receptor, a nucleotide signaling protein, is activated by uridine-5′-diphosphoglucose 1 and other uracil nucleotides. We have determined that the glucose moiety of 1 is the most structurally permissive region for designing analogues of this P2Y14 agonist. For example, the carboxylate group of uridine-5′-diphosphoglucuronic acid proved to be suitable for flexible substitution by chain extension through an amide linkage. Functionalized congeners containing terminal 2-acylaminoethylamides prepared by this stratgegy retained P2Y14 activity, and molecular modeling predicted close proximity of this chain to the 2nd extracellular loop of the receptor. In addition, replacement of glucose with other sugars did not diminish P2Y14 potency. For example, the [5″]ribose derivative had an EC50 of 0.24 μM. Selective monofluorination of the glucose moiety indicated a role for the 2″- and 6″-hydroxyl groups of 1 in receptor recognition. The β-glucoside was 2-fold less potent than the native α-isomer, but methylene replacement of the 1″-oxygen abolished activity. Replacement of the ribose ring system with cyclopentyl or rigid bicyclo[3.1.0]hexane groups abolished activity. Uridine-5′-diphosphoglucose also activates the P2Y2 receptor, but the 2-thio analogue and several of the potent modified-glucose analogues were P2Y14-selective.
Evaluation of barrier uniformity in magnetic tunnel junctions prepared using natural oxidation of thin Mg layers (2010)

We fabricated submicron magnetic tunnel junctions (MTJs) using natural oxidation of thin Mg layers deposited by dc sputtering. The MTJs exhibited magnetoresistance (MR) ratios of up to about 150% with a low resistance-area product (RpA) of 8 Ω μm2, which are comparable to those for radio-frequency-sputtered MgO barriers. The submicron MTJs had highly variable MR and RpA values due to a high pinhole density (20 μm−2) in the barriers, whereas current-in-plane-tunneling (CIPT) measurements on the same MTJ films revealed highly reproducible MR and RpA values. This indicates that reproducible CIPT measurements do not necessarily give accurate results of MR and RpA at high pinhole densities.
4-(Aminomethyl)-1-Aryl-2-Pyrrolidinones, A New Class of Monoamine Oxidase B Inactivators (1992)

Both 4-(aminomethyl)-l-phenyl-2-pyrrolidinone (4a) and 4-(aminomethyl)-1-(methoxyphenyl)-2-pyr-rolidinone (4b) hydrochlorides were synthesized via a six-step sequence, which represents a general approach to 1,4-disubstituted 2-pyrrolidinones. Both of these compounds inactivated monoamine oxidase B and represent the first in a new class of monomamine oxidase inactivators.
A Ketogenic Diet in Combination With Gemcitabine Mitigates Pancreatic Cancer Associated Cachexia in Male and Female KPC Mice (2023)

Cancer associated cachexia (CAC) is a critical contributor to pancreatic ductal adenocarcinoma (PDAC) mortality. Thus, there is an urgent need for new strategies to mitigate PDAC-associated cachexia; and the exploration of dietary interventions is a critical component. We previously observed that a ketogenic diet (KD) combined with gemcitabine enhances overall survival in the autochthonous LSL-KrasG12D/+; LSL-Trp53 R172H/+; Pdx1-Cre (KPC) mouse model. In this study, we investigated the effect and cellular mechanisms of a KD in combination with gemcitabine on the maintenance of skeletal muscle mass in KPC mice. For this purpose, male and female pancreatic tumor-bearing KPC mice were allocated to a control diet (CD), a KD, a CD + gemcitabine (CG), or a KD + gemcitabine (KG) group. We observed that a KD or a KG mitigated muscle strength decline over time and presented higher gastrocnemius weights compared CD-fed mice. Mechanistically, we observed sex-dependent effects of KG treatment, including the inhibition of autophagy, and increased phosphorylation levels of eIF2α in KG-treated KPC mice when compared to CG-treated mice. Our data suggests that a KG results in preservation of skeletal muscle mass. Additional research is warranted to explore whether this diet-treatment combination can be clinically effective in combating CAC in PDAC patients.
An intelligent hand-held microsurgical instrument for improved accuracy (2005)

This paper presents the development and initial experimental results of the first prototype of Micron, an active hand-held instrument to sense and compensate physiological tremor and other unwanted movement during vitreoretinal microsurgery. The instrument incorporates six inertial sensors, allowing the motion of the tip to be computed. The motion captured is processed to discriminate between desired and undesired components of motion. Tremor canceling is implemented via the weighted-frequency Fourier linear combiner (WFLC) algorithm, and compensation of non-tremorous error via a neural-network technique is being investigated. The instrument tip is attached to a three-degree-of-freedom parallel manipulator with piezoelectric actuation. The actuators move the tool tip in opposition to the tremor, thereby suppressing the erroneous motion. Motion canceling experiments with oscillatory motions in the frequency band of physiological tremor show that Micron is able to reduce error amplitude by 45.3% in 1-D tests and 34.3% in 3-D tests.
A new bi-primary color system for doubling the reflectance and colorfulness of e-paper (2011)

There are several paradigms for color generation in reflective displays (e-Paper) including RGBW color filtering or stacked RGB or CMY. Theoretically, the highest white state reflectance and best color gamut are achieved by stacking three layers of pixels. However, stacking 3 layers induces significant optical losses especially at high resolution and typically does not allow for video operation. Therefore RGBW color filtering is currently preferred for higher resolution and single-layer e-Paper, but only provides color at 25% of the area and a maximum theoretical white reflectance of 50%. Presented herein is a new bi-primary color-system that cooperatively displays two complimentary colors inside a single sub-pixel, and therefore doubles the white state reflectance and color gamut for single-layer e-Paper. Also discussed are candidate e-Paper technologies that may be able to adopt the bi-primary color system, including possible advantages and challenges for each technology.
Supplementary Figure 4 from Transforming Growth Factor-β Activation Promotes Genetic Context–Dependent Invasion of Immortalized Melanocytes (2023)

Supplementary Figure 4 from Transforming Growth Factor-β Activation Promotes Genetic Context–Dependent Invasion of Immortalized Melanocytes
Supplementary Video S2 from Gain-of-Function <i>RHOA</i> Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer (2023)

&lt;p&gt;Supplementary Video S2&lt;/p&gt;
Conoscopic Observations of Multiple Ferrielectricity in a Chiral Liquid Crystal (1999)

Abstract The sequence of antiferroelectric, ferrielectric and ferroelectric phases in the material AS573 (Hull, UK) has been investigated via conoscopy and selective reflection. Evidence was found to support the division of the phase previously labelled SmC*γ into two ferrielectric subphases. A revised phase sequence for the material, based on this study, is presented.
High efficiency coupling to metal-insulator-metal plasmonic waveguides (2022)

A periodic array of dual-Vivaldi antennas integrated with metal-insulator-metal (MIM) plasmonic waveguides was designed and investigated for its infrared light absorbance efficiency. Full-wave analysis was used to optimize MIM waveguides compatible with parallel and series connected DC leads without sacrificing radiation efficiency. Free-space to MIM waveguide in-coupling efficiency as high as 41% has been obtained in a sub-wavelength unit cell geometry at a wavelength of 1373 nm. Higher efficiency, up to 85%, is predicted with a modified design including a backplane reflector. A nanofabrication process was developed to realize test devices and far-field optical spectroscopy was used as experimental evidence for antenna-waveguide matching.
CCR2 chemokine binding to heparan sulfate by ESI FT‐ICR mass spectrometry (2006)

Chemokines are known to bind to glycosaminoglycans (GAGs), the long polysaccharide components of cell surface proteoglycans and the extracellular matrix (ECM). The predominant cell surface GAG is heparan sulfate (HS). However heparin is usually studied in place of HS in GAG binding assays. HS, while structurally related to heparin, is actually less sulfated, more acetylated, and more heterogenous in nature. We set out to characterize the noncovalent interactions of chemokines of the receptor CCR2 with octasaccharides generated from a HS digest. The analysis was performed using electrospray ionization (ESI) Fourier transform‐ ion cyclotron resonance mass spectrometry (FT‐ICR MS). Our data suggest that the CCR2 chemokines bind to highly sulfated HS oligosaccharides. Taken together with the heterogenous nature of intact HS, this suggests that in vivo these chemokines may be retained on specific highly sulfated loci.
Synthesis of S‐2‐((S)‐3‐(4‐chlorophenyl)‐N'‐((4‐chlorophenyl)sulfonyl)‐4‐phenyl‐4,5‐dihydro‐1H‐pyrazole‐1‐carboximidamido)‐3‐(methyl‐d3)butanamide‐d5, octadeuterated JD5037 (2017)

JD5037 (1) is a potent and selective, peripherally acting inverse agonist of the cannabinoid (CB<sub>1</sub> R) receptor. Peripheral CB<sub>1</sub> receptor antagonists/inverse agonists have great potential in the treatment of metabolic disorders like type 2 diabetes, obesity, and nonalcoholic steatohepatitis. We report the synthesis of octadeuterated [<sup>2</sup> H<sub>8</sub> ]-JD5037 (S, S) (8) along with its (S, R) diastereomer (13) from commercially available L-valine-d<sub>8</sub> starting material. The [<sup>2</sup> H<sub>8</sub> ]-JD5037 compound will be used to quantitate unlabeled JD5037 during clinical ADME studies and will be used as an LC-MS/MS bioanalytical standard.
ChemInform Abstract: Unexpected Asymmetric Epoxidation Reactions Catalyzed by Polyleucine‐ Based Systems. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
LTE-A Mobile Fronthaul Exploiting Pulse-Width Modulation in a RSOA-based WDM PON (2016)

Pulse width modulation for optical C-RAN fronthauling of 100-MHz bandwidth LTE-A signals is proved for the first time in a colorless self-tuning WDM PON, exploiting broadband-seeded RSOAs. Transmission up to 20-km SSMF is experimentally demonstrated.
Characteristics of Children With Primary Congenital Glaucoma Receiving Trabeculotomy and Goniotomy (2015)

Patients with PCG who underwent trabeculotomy had higher IOP and were treated at an earlier age than those who had goniotomy. Both effectively lowered IOP up to 2 years with greater medication burden in patients receiving goniotomy.
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells (2002)

Interactions between endothelial cells (ECs) and perivascular mural cells (MCs) via signaling molecules or physical contacts are implicated both in vascular remodeling and maintenance of vascular integrity. However, it remains unclear how MCs regulate the morphogenic activity of ECs to form an organized vascular architecture, comprising distinct artery, vein, and capillary, from a simple mesh-like network. A clear elucidation of this question requires an experimental model system in which ECs are separated from MCs and yet form vascular structures. Here we report that injection of an antagonistic mAb against PDGFR-β into murine neonates provides such an experimental system in the retina by completely blocking MC recruitment to developing vessels. While a vascular network was formed even in the absence of MCs, it was poorly remodeled and leaky. Using this vascular system ideal for direct assessment of the activities of MC-derived molecules, we show that addition of recombinant modified angiopoietin-1 restored a hierarchical vasculature, and also rescued retinal edema and hemorrhage in the complete absence of MCs. These observations demonstrate the potential of Ang1 as a new therapeutic modality for MC dropout in diseases such as diabetic retinopathies.
The Association of ARMC5 with the Renin-Angiotensin-Aldosterone System, Blood Pressure, and Glycemia in African Americans (2020)

ARMC5 variants are associated with aldosterone, PRA, blood pressure, fasting glucose, and HbA1c in community-dwelling AAs, suggesting that germline mutations in ARMC5 may underlie cardiometabolic disease in AAs.
Current density enhancement nano-contact phase-change memory for low writing current (2013)

In this work, a phase-change memory (PCM) with self-assembled nanostructures and an oxidized thin phase-change layer is proposed and intensively investigated for low writing reset current by finite element analysis. Current density is significantly enhanced in our nano-contact memory because of the existence of nanostructures and oxidized phase-change layer. The writing current of our proposed memory is about 1/10-3/10 that of conventional cell, which is in good agreement with our experimental results. The heat efficiency in the nano-contact PCM cell is greatly improved and its power consumption can be as low as about 1/10 that of the conventional cell.
QuantitativeRARβ2Hypermethylation (2004)

Retinoic acid receptor beta2 (RARbeta2) is a tumor suppressor gene frequently hypermethylated in several human neoplasms. To further characterize this epigenetic alteration in prostate cancer progression, we examined tumor tissue from 118 patients with prostate carcinoma (PCa), 38 paired high-grade prostatic intraepithelial neoplasias (HGPIN), and non-neoplastic prostate tissue from 30 patients with benign prostate hyperplasia (BPH), using quantitative methylation-specific PCR. We found RARbeta2 hypermethylation in 97.5% of PCa, 94.7% of HGPIN, and 23.3% of BPH. Methylation levels were significantly higher in PCa compared with HGPIN and BPH (P < 0.00001). By establishing an empiric cutoff value, we were able to discriminate between neoplastic and non-neoplastic tissue, with 94.9% sensitivity and 100% specificity. Moreover, RARbeta2 methylation levels correlated with higher pathological stage (r = 0.30, P = 0.0009). This quantitative assay represents a novel and promising molecular marker that may augment current approaches for prostate cancer detection.
Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages (2008)

Multicellular animals use a three-part molecular toolkit to mediate phospho-tyrosine signaling: Tyrosine kinases (TyrK), protein tyrosine phosphatases (PTP), and Src Homology 2 (SH2) domains function, respectively, as "writers," "erasers," and "readers" of phospho-tyrosine modifications. How did this system of three components evolve, given their interdependent function? Here, we examine the usage of these components in 41 eukaryotic genomes, including the newly sequenced genome of the choanoflagellate, Monosiga brevicollis, the closest known unicellular relative to metazoans. This analysis indicates that SH2 and PTP domains likely evolved earliest-a handful of these domains are found in premetazoan eukaryotes lacking tyrosine kinases, most likely to deal with limited tyrosine phosphorylation cross-catalyzed by promiscuous Ser/Thr kinases. Modern TyrK proteins, however, are only observed in two lineages, metazoans and choanoflagellates. These two lineages show a dramatic coexpansion of all three domain families. Concurrent expansion of the three domain families is consistent with a stepwise evolutionary model in which preexisting SH2 and PTP domains were of limited utility until the appearance of the TyrK domain in the last common ancestor of metazoans and choanoflagellates. The emergence of the full three-component signaling system, with its dramatically increased encoding potential, may have contributed to the advent of metazoan multicellularity.
Katalytische C-C-Bindungsknüpfung durch selektive Aktivierung von C-F-Bindungen (2001)

Die Aktivierung reaktionsträger sp2-C-F-Bindungen ist in katalytischen C-C-Kreuzkupplungen mit Aryl-Grignard-Verbindungen unter milden Bedingungen möglich: Ein Nickelkomplex mit einem N-heterocyclischen Carbenliganden ist der aktivste Katalysator für diese Reaktion [Gl. (1)]. Mit der selektiven Aktivierung aromatischer C-F-Bindungen in Gegenwart von C-H-Bindungen hat die Kreuzkupplungschemie nun ihr höchstes Niveau bezüglich der Katalysatoraktivität erreicht. Hintergrundinformationen zu diesem Beitrag sind im WWW unter http://www.angewandte.de zu finden oder können beim Autor angefordert werden. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
RDF recipes for context-aware interoperability in pervasive systems (2010)

Nowadays home automation systems integrate many devices from security system, heating, ventilation and air conditioning system, lighting system or audio-video systems. Every time a new device is installed, problems with connecting it to other devices and synchronization may appear. The technology trends are to build more powerful and functional new autonomous devices, rather than improve device synchronization, data and functional distribution and adaptation to changing environment. This paper highlights interoperability problems in pervasive computing and presents a solution for devices with limited processing capabilities by use of an ontology for knowledge formulation and semantic interoperability.
Comparison of Surgical Freedom and Area of Exposure in Three Endoscopic Transmaxillary Approaches to the Anterolateral Cranial Base (2013)

Introduction: Minimal access endoscopic transmaxillary approaches have shown utility in the resection of lesions within the retromaxillary space and pterygopalatine fossa. The ipsilateral endonasal exposure may be enhanced by several maneuvers, including a contralateral transseptal approach, endoscopic Denker's procedure, and endoscopic Caldwell-Luc approach. In this anatomic study, we compare the exposure and surgical freedom of these three different transmaxillary approaches. This information may be helpful for preoperative approach selection.
ChemInform Abstract: A Mild and Effective Method for the Transesterification of Carboxylic Acid Esters. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Vinculin phosphorylation in response to calcium and phorbol esters in intact cells. (1984)

Vinculin phosphorylation in both chick embryo fibroblasts and Swiss 3T3 cells was increased by either calcium or biologically active phorbol esters. Increased phosphorylation of vinculin was noted as early as 10 min following phorbol 12-myristate 13-acetate treatment and was maximal at about 1 h. Maximal increases in phosphorylation were noted at approximately 100 nM phorbol 12-myristate 13-acetate. Phorbol 12,13-dibutyrate (80 nM), a less potent phorbol ester, resulted in smaller increases in vinculin phosphorylation than phorbol 12-myristate 13-acetate at equimolar concentrations. Phorbol, dibutyryl cAMP, and dibutyryl cGMP had no significant effect on phosphorylation. No correlation was found between vinculin phosphorylation and the morphological changes induced by phorbol esters. Tryptic peptide analysis of vinculin revealed multisite phosphorylation. Phosphorylation of only three of the peptides was significantly increased following phorbol 12-myristate 13-acetate treatment. Phosphoamino acid analysis revealed increases at both serine and threonine residues. The low level of phosphotyrosine present in control cells was not significantly increased by phorbol 12-myristate 13-acetate treatment. These findings combined with studies of vinculin phosphorylation by purified protein kinase C (Werth, D. K., Niedel, J. E., and Pastan I. (1983) J. Biol. Chem. 258, 11423-11426) suggest the hypothesis that protein kinase C may be involved in regulation of phosphorylation of vinculin, a cytoskeletal protein.
Regioselective Synthesis ofa Potent Src Kinase Inhibitor: 4-(2,4-Dichloro-5-methoxyphenylamino)-7-methoxy-8-(2-morpholin-4-ylethoxy)benzo[g]quinoline-3-carbonitrile (2003)

The regioselective synthesis of compound 3, a potent Src kinase inhibitor is described. A key step in this synthesis is the regio­selective thermal rearrangement of a substituted benzocyclobutene to provide a 2,3,6,7-tetrasubstituted naphthalene. An efficient route to the uniquely substituted benzocyclobutene is reported.