MP05-04 CLINICALLY SIGNIFICANT PROSTATE CANCER DETECTION RATES ON MRI GUIDED FUSION NEEDLE BIOPSY - EXPERIENCE FROM THE PENNSYLVANIA UROLOGIC REGIONAL COLLABORATIVE (2021)

You have accessJournal of UrologyProstate Cancer: Detection & Screening I (MP05)1 Sep 2021MP05-04 CLINICALLY SIGNIFICANT PROSTATE CANCER DETECTION RATES ON MRI GUIDED FUSION NEEDLE BIOPSY - EXPERIENCE FROM THE PENNSYLVANIA UROLOGIC REGIONAL COLLABORATIVE Ako Adams Ako, Serge Ginzburg, Eric Singer, Bruce Jacobs, Claudette Fonshell, Adam Reese, Edouard Trabulsi, Jeffery Tomaszewski, John Danella, Laurence Belkoff, Thomas Guzzo, Robert Uzzo, and Jay Raman Ako Adams AkoAko Adams Ako More articles by this author , Serge GinzburgSerge Ginzburg More articles by this author , Eric SingerEric Singer More articles by this author , Bruce JacobsBruce Jacobs More articles by this author , Claudette FonshellClaudette Fonshell More articles by this author , Adam ReeseAdam Reese More articles by this author , Edouard TrabulsiEdouard Trabulsi More articles by this author , Jeffery TomaszewskiJeffery Tomaszewski More articles by this author , John DanellaJohn Danella More articles by this author , Laurence BelkoffLaurence Belkoff More articles by this author , Thomas GuzzoThomas Guzzo More articles by this author , Robert UzzoRobert Uzzo More articles by this author , and Jay RamanJay Raman More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001972.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Magnetic resonance imaging (MRI) fusion needle biopsy has been shown to outperform systematic biopsy in detecting clinically significant prostate cancer. This study sought to: 1) Examine the variability of clinically significant prostate cancer detection rates in a large, regional quality improvement collaborative. 2) Examine the association between patient characteristics and clinically significant prostate cancer detection. METHODS: The Pennsylvania Urologic Regional Collaborative (PURC) is a physician-led data-sharing and quality improvement collaborative comprised of urology practices across Pennsylvania and New Jersey. We analyzed 857 first-time MRI fusion biopsy procedures performed at 5 PURC practices with a minimum of 30 procedures between January 2015 and June 2019. Chi-square tests and hierarchical logistic regression analyzed the variability in cancer detection rates by practice and the association between patient characteristics and Gleason ≥4+3 tumor detection. RESULTS: Median prostate specific antigen (PSA) was 6.8 ng/ml, 14.4% of men were ≤59 years old. Detection rates for Gleason ≥4+3 tumors by practice ranged from 14.3% to 28.3% (p=0.02). Age, digital rectal examination, PSA, gland volume and Prostate Imaging-Reporting and Data System version2 (PI-RADSv2) score were significantly associated with Gleason ≥4+3 tumors. Adjusting for patient characteristics demonstrated that there was no significant variation in Gleason ≥4+3 tumor detection by practice (Intercept variance = 0.04; p=0.26). PIRADSv2 ≥4 was associated with increased likelihood of detecting a Gleason ≥4+3 tumor (OR 2.67; 95% CI 1.76–4.07; p<0.0001). CONCLUSIONS: Variability in clinically significant prostate cancer detection between individual practice sites was predominantly due to variability in patient characteristics. Results highlight the importance of pre-biopsy MRI in the diagnosis of clinically significant prostate cancer. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e77-e78 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ako Adams Ako More articles by this author Serge Ginzburg More articles by this author Eric Singer More articles by this author Bruce Jacobs More articles by this author Claudette Fonshell More articles by this author Adam Reese More articles by this author Edouard Trabulsi More articles by this author Jeffery Tomaszewski More articles by this author John Danella More articles by this author Laurence Belkoff More articles by this author Thomas Guzzo More articles by this author Robert Uzzo More articles by this author Jay Raman More articles by this author Expand All Advertisement Loading ...