gebhart/patrepeval huggingface dataset:
Unlimited range for electric vehicles (2014)

The dynamic inductive power transfer for Electric Vehicles is a solution to fill the main drawback of electric vehicles, namely autonomy. Compatible with the static inductive charging, this solution also provides high added value because there are no more cable handling, the charge is done transparently to the user. This value can be a constraint if it is necessary to position the EV very precisely in order to recharge. The wireless charger must be sufficiently tolerant to misalignment. Although already developed in other articles, the selected topology, combined with clever design based on Fresnel diagrams and simple control but with a significant dynamic, allows a large misalignment without loss of power or efficiency. The control method makes the charger compatible with the on-road charging. A demonstrator of 2kW under 60V, currently achieved, can demonstrate the performance of this topology, especially during movements of the secondary side relative to the primary side. We propose, in this paper, to control the output voltage and enable operation at low power to make the entire system a complete and efficient charger, while being able to operate dynamically. This control is done without any communication between the primary side and the secondary side of the transformer.
EFFECTS OF DORSAL FLANGES ON FIXATION OF A CEMENTED TOTAL HIP REPLACEMENT FEMORAL STEM (2004)

Flanges on a total hip femoral stem increase the interlock between the stem and the cement and decrease the proximal-medial stress-shielding. However, these advantages occur with increased bone-cement interface motion, which may be detrimental to the survival of the implant.
3D Photonics in the Mid-infrared: Parametric study of ultrafast laser inscribed waveguides for stellar interferometry (2016)

We present a study on glass materials that are potentially suitable for the fabrication of low-loss waveguides in the mid-infrared, more specifically in the region 3 - 5 µm. The mid-infrared is especially interesting for applications such as molecular fingerprinting and interferometry for Earth-like exoplanet hunting. We study the optical properties of different glasses and use the femtosecond laser direct-write technique to inscribe waveguides inside them. We characterized the single-mode transmission properties of the waveguides, mode confinement and induced refractive index change as well as determined the waveguide propagation losses.
Fairing Noise Control Using Tube-Shaped Resonators (2003)

Abstract : The potential for noise mitigation in composite Chamber Core fairings is investigated by using the walls of the fairing structure itself as acoustic resonators. This is the first documented application of long cylindrical tube-shaped resonators for fairing noise control. The theory and modeling of tube-shaped resonators for controlling fairing acoustic resonances is presented. The potential for noise mitigation in composite Chamber Core fairing using the walls of the fairing structure itself as acoustic resonators is investigated. Design criteria such as geometry damping, spatial coupling, and robustness are considered for a variety of tube resonators. The results showed that a small number of tube resonators reduced the amplitude of low-frequency acoustic resonances by 10-12 dB in the test system and provided nearly 6 dB of reduction over the bandwidth from 0 to 400 Hz.
Effects of semiconductor-dielectric interfaces on polymeric thin-film transistors (2005)

The interface between the semiconducting polymer and the gate dielectric is one of the most critical regions of a polymeric thin film transistor. For polymeric TFTs, it is difficult to disaggregate the contributions of the electronic structure of the semiconductor and that of the dielectric because, in part, the microstructure of thin films of semiconducting polymers is strongly affected by the chemical functionality at the surface of the dielectric. We have developed a lamination technique that can be used to transfer semiconducting films formed on surfaces that yield films with high mobility to other dielectrics. We have studied films of semiconducting polymers, such as poly[5,5'-bis(3-dodecyl-2-thienyl)-2,2'-bithiophene] and poly(3-hexylthiophene) using this method. The effects of self-assembled monolayers (SAMs) formed on inorganic dielectrics on device performance are discussed. Our results suggest that mobility is mainly controlled by the structure of the semiconducting film and that the threshold voltage of TFTs may be modified through the use of SAMs.
High accurate and broadband optical comb generation using MZM-based flat comb generator and soliton compression (2009)

We report on 20 THz-wide optical frequency comb generation for wide-rage tunable MM and THz wave generation. A broadband comb signal was created from CW light by using a Mach-Zehnder modulator and a dispersion-flattened dispersion-decreasing fiber (DF-DDF). A comb signal was drastically broadened to 20 THz by increasing the input power to the DF-DDF. Our method is based on optical modulation using a Mach-Zehnder modulator, so that it is possible to generate comb signals with high-stable and high-accuracy.
Synthesis of Graphite Encapsulated Metal Nanoparticles and Metal Catalyzed Nanotubes (1999)

This work focuses on the growth and inception of graphite encapsulated metal nanoparticles and metal catalyzed nanotubes using combustion chemistry. Deciphering the inception and growth mechanism(s) for these unique nanostructures is essential for purposeful synthesis. Detailed knowledge of these mechanism(s) may yield insights into alternative synthesis pathways or provide data on unfavorable conditions. Production of these materials is highly desirable given many promising technological applications.
Anderson localization of light in two-dimensional random media (2011)

Light propagation in two-dimensional random configurations of dielectric cylindrical columns adopting parameters of gallium nitride nanocolumns via the finite-difference time-domain method is simulated. The sample area is 5 μm square (L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sys</sub> = 5 μm), and consists of an array of the parallel columns with a constant radius (R = 50 nm) and a constant refractive index (n= 2.4). The columns are placed randomly not to touch each other, and they are embedded in vacuum. Under these conditions, the localization effect depends only on the column filling fraction Φ and the light frequency f. In the simulation, a transverse magnetic white pulse onto the center of the system is irradiated, and the temporal evolution of the field is recorded. The photon lifetime of the system at several frequencies τ(f) by Fourier analysis is then calculated.
Detoxification and scattering suppression of asbestos-containing material using a laser beam (2022)

The use of asbestos, a substance widely recognized as toxic, is banned in many countries, and the demolition of asbestos-containing buildings has increased in recent years in Japan. Conventional methods of removing asbestos-containing materials pose a risk of lung cancer and other diseases because they scatter asbestos in the air. Here, we demonstrate that a laser beam can be used to detoxify asbestos and suppress its scattering. The scattering of amorphous materials with the same composition as asbestos was observed in dust of asbestos-containing materials.
(Virtual) Identity Communication: Motivations and Contextual Factors (2017)

Although prior literature has explored the important process of identity communication in face- to-face settings, significant changes in how work is accomplished in modern organizations require the development of new theory. Building on extensive identity research in non-virtual settings, this paper develops and justifies a new theoretical model that better explains the antecedents of virtual identity communication. The model explores how identity motives lead to identity communication, and how virtual communication environments alter these processes. We summarize our data collection methodology and the results of a preliminary data collection and conclude by discussing theoretical and practical contributions. The concepts and relationships presented here can help theorists and managers better address identity issues faced by modern, technology-infused organizations. \
Cell death proteins (1997)

Cell Cycle Checkpoints and Apoptosis: Potential for Improving Radiation Therapy. Structure and Function of Interleukin-1B Converting Enzyme. The Role of IGF-I Receptor in Apoptosis. BCL-2 Family of Proteins and the Hormonal Control of Cell Life and Death in Normalcy and Neoplasia. Pathways of P53-Dependent Apoptosis. Viral Inhibitors of Apoptosis. Chapter References. Subject Index.
Aerococcus urinae and Globicatella sanguinis Persist in Polymicrobial Urethral Catheter Biofilms Examined in Longitudinal Profiles at the Proteomic Level (2019)

<i>Aerococcus urinae</i> (<i>Au</i>) and <i>Globicatella sanguinis</i> (<i>Gs</i>) are gram-positive bacteria belonging to the family Aerococcaceae and colonize the human immunocompromised and catheterized urinary tract. We identified both pathogens in polymicrobial urethral catheter biofilms (CBs) with a combination of 16S rDNA sequencing, proteomic analyses, and microbial cultures. Longitudinal sampling of biofilms from serially replaced catheters revealed that each species persisted in the urinary tract of a patient in cohabitation with 1 or more gram-negative uropathogens. The <i>Gs</i> and <i>Au</i> proteomes revealed active glycolytic, heterolactic fermentation, and peptide catabolic energy metabolism pathways in an anaerobic milieu. A few phosphotransferase system (PTS)-based sugar uptake and oligopeptide ABC transport systems were highly expressed, indicating adaptations to the supply of nutrients in urine and from exfoliating squamous epithelial and urothelial cells. Differences in the <i>Au</i> vs <i>Gs</i> metabolisms pertained to citrate lyase and utilization and storage of glycogen (evident only in <i>Gs</i> proteomes) and to the enzyme Xfp that degrades d-xylulose-5'-phosphate and the biosynthetic pathways for 2 protein cofactors, pyridoxal 6'-phosphate and 4'-phosphopantothenate (expressed only in <i>Au</i> proteomes). A predicted ZnuA-like transition metal ion uptake system was identified for <i>Gs</i> while <i>Au</i> expressed 2 LPXTG-anchored surface proteins, one of which had a predicted pilin D adhesion motif. While these proteins may contribute to fitness and virulence in the human host, it cannot be ruled out that <i>Au</i> and <i>Gs</i> fill a niche in polymicrobial biofilms without being the direct cause of injury in urothelial tissues.
Conformational studies on the N‐linked carbohydrate chain of bromelain (1990)

1H- and 13C-NMR assignments for the carbohydrate part of the glycopeptide alpha-D-Man-(1----6)-[beta-D-Xyl-(1----2)]-beta-D-Man-(1----4)-beta-D- GlcNAc-(1----4)-[alpha-L-Fuc-(1----3)]-beta-D-GlcNAc-(1----N)-Asn approximately, derived from the proteolytic enzyme bromelain (EC 3.4.22.4), have been obtained using homo- and heteronuclear correlation spectroscopy, two-dimensional homonuclear Hartmann-Hahn and nuclear Overhauser enhancement experiments. A conformational model for the carbohydrate chain, deduced from the NMR data and consistent with hard-sphere exo-anomeric calculations shows that the rotamer population about the C-5--C-6 bond of beta-Man is restricted to the P omega = 180 rotamer, mainly.
MACiE: exploring the diversity of biochemical reactions (2011)

MACiE (which stands for Mechanism, Annotation and Classification in Enzymes) is a database of enzyme reaction mechanisms, and can be accessed from http://www.ebi.ac.uk/thornton-srv/databases/MACiE/. This article presents the release of Version 3 of MACiE, which not only extends the dataset to 335 entries, covering 182 of the EC sub-subclasses with a crystal structure available (~90%), but also incorporates greater chemical and structural detail. This version of MACiE represents a shift in emphasis for new entries, from non-homologous representatives covering EC reaction space to enzymes with mechanisms of interest to our users and collaborators with a view to exploring the chemical diversity of life. We present new tools for exploring the data in MACiE and comparing entries as well as new analyses of the data and new searches, many of which can now be accessed via dedicated Perl scripts.
Sanguinarine Increases Sensitivity of Human Gastric Adenocarcinoma Cells to TRAIL-mediated Apoptosis by Inducing DR5 Expression and ROS Generation (2014)

혈근초(Sanguinaria canadensis) 뿌리에서 유래된 benzophenanthridine alkaloid의 일종인 sanguinarine은 항균, 항산화 및 항암작용 등 다양한 생리활성을 지니고 있는 것으로 알려져 있다. 비록 TRAIL이 암세포에서는 apoptosis를 유도하지만 정상세포에서는 세포독성을 나타내지 않는다는 큰 장점으로 제 2 임상 단계에서 유의적인 성과를 이루었지만, TRAIL 저항성을 극복해야 하는 큰 어려움이 남아있다. 본 연구실에서는 TRAIL이 세포독성을 나타내지 않는 범위의 sanguinarine과 혼합처리에 의하여 TRAIL 저항성 AGS 위암세포에서 apoptosis를 유발하였음을 보고한 바 있으며, 본 연구에서는 sanguinarine의 TRAIL 저항성 관련 극복에 대한 추가적인 기전 연구를 실시하였다. 본 연구의 결과에 의하면, sanguinarine과 TRAIL의 혼합처리는 각각의 단독 처리에 비하여 AGS 세포의 증식억제 및 apoptosis 유도의 상승 효과가 있었으며, 이를 MTT assay, agarode gel 전기영동, 염색질 응축 현상 및 flow cytometry 분석을 통하여 확인하였다. 또한 sanguinarine과 TRAIL의 혼합처리는 DR5의 발현을 증가시켰으며, ROS의 생성을 촉진시켰다. 그러나 동일 조건에서 MAPKs 신호 전달계에는 큰 영향을 주지 않았다. 아울러 ROS 생성을 인위적으로 차단하였을 경우, sanguinarine과 TRAIL의 혼합처리에 의한 생존도 저하가 유의적으로 회복되었다. 이러한 결과는 sanguinarine과 TRAIL이 DR5의 발현 증가와 ROS의 생성을 촉진시킴으로서 apoptosis 신호를 활성화하였음을 의미하는 결과로서 TRAIL 저항성 극복을 위한 sanguinarine 활용의 유용성을 보여주는 것이다. Sanguinarine, a benzophenanthridine alkaloid originally derived from the root of Sanguinaria canadensis, has been shown to possess antimicrobial, antioxidant, and anti-cancer properties. Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is known to induce apoptosis in cancer cells, but not most normal cells and has shown efficacy in a phase 2 clinical trial, development of resistance to TRAIL by tumor cells is a major roadblock. Our previous study indicated that treatment with TRAIL in combination with subtoxic concentrations of sanguinarine sensitized TRAIL-mediated apoptosis in TRAIL-resistant human gastric carcinoma AGS cells; however, the detailed mechanisms are not fully understood. In this study, we show that sanguinarine sensitizes AGS cells to TRAIL-mediated apoptosis as detected by MTT assay, agarose gel electrophoresis, chromatin condensation and flow cytometry analysis. Combined treatment with sanguinarine and TRAIL effectively induced expression of death receptor (DR) 5 but did not affect expression of DR4 and mitogen activated protein kinases signaling molecules. Moreover, the combined treatment with sanguinarine and TRAIL increased the generation of reactive oxygen species (ROS); however, N-acetylcysteine, ROS scavenger, significantly recovered growth inhibition induced by the combined treatment. Taken together, our results indicate that sanguinarine can potentiate TRAIL-mediated apoptosis through upregulation of DR5 expression and ROS generation.
Investigation of Lamb waves in solid-liquid layers (2015)

Lamb waves are used in non-destructive testing to detect defects or corrosion of walls of pipes or other sensitive constructions. Depending on the used mode of the Lamb wave the propagation of the waves can be influenced by the presence of liquids as it e.g. occurs in liquid filled pipes. The here occurring leaky Lamb waves has therefore already been investigated in the past. In addition also in non-filled pipes liquids can cover the wall either due to condensation out of a saturated gas phase or due to remains of water on a former filled pipe. The liquid would then cover the wall partly as a layer and could also influence the propagation of the Lamb waves. In this paper the propagation of Lamb waves is therefore investigated in partially or fully covered plates with liquid layers showing the damping of the waves at the beginning and along the liquid layers.
Figure S5 from RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy (2023)

&lt;p&gt;Taselisib-mediated degradation of mutant p110a occurs preferentially at the plasma membrane.&lt;/p&gt;
Solution structure and proposed domain–domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase (2007)

Polyketides are a medicinally important class of natural products. The architecture of modular polyketide synthases (PKSs), composed of multiple covalently linked domains grouped into modules, provides an attractive framework for engineering novel polyketide-producing assemblies. However, impaired domain-domain interactions can compromise the efficiency of engineered polyketide biosynthesis. To facilitate the study of these domain-domain interactions, we have used nuclear magnetic resonance (NMR) spectroscopy to determine the first solution structure of an acyl carrier protein (ACP) domain from a modular PKS, 6-deoxyerythronolide B synthase (DEBS). The tertiary fold of this 10-kD domain is a three-helical bundle; an additional short helix in the second loop also contributes to the core helical packing. Superposition of residues 14-94 of the ensemble on the mean structure yields an average atomic RMSD of 0.64 +/- 0.09 Angstrom for the backbone atoms (1.21 +/- 0.13 Angstrom for all non-hydrogen atoms). The three major helices superimpose with a backbone RMSD of 0.48 +/- 0.10 Angstrom (0.99 +/- 0.11 Angstrom for non-hydrogen atoms). Based on this solution structure, homology models were constructed for five other DEBS ACP domains. Comparison of their steric and electrostatic surfaces at the putative interaction interface (centered on helix II) suggests a model for protein-protein recognition of ACP domains, consistent with the previously observed specificity. Site-directed mutagenesis experiments indicate that two of the identified residues influence the specificity of ACP recognition.
Erratum to: Search for supersymmetry in events containing a same-flavour opposite-sign dilepton pair, jets, and large missing transverse momentum in $$\sqrt{s}=8$$ s = 8 TeV pp collisions with the ATLAS detector (2015)

It has been found that one of the signal models in Figs. 5 and 9 was incorrectly labelled in the legend. The label has been fixed, while none of the results or exclusions have changed.
Thin-film optimization strategy in high numerical aperture optical lithography, part 1: principles (2005)

The functional dependence of a resist critical dimension (CD) with respect to resist thickness for a general absorptive thin-film stack in the case of oblique incidence is derived analytically with the rigorous electromagnetic theory. Based on obtained results, we discuss those thin-film effects related to CD control, such as the swing effect, bulk effect, etc., especially in the regime of high numerical aperture optical lithography.
Isotope-reinforced polyunsaturated fatty acids improve Parkinson’s disease-like phenotype in rats overexpressing α-synuclein (2020)

Lipid peroxidation is a key to a portfolio of neurodegenerative diseases and plays a central role in α-synuclein (α-syn) toxicity, mitochondrial dysfunction and neuronal death, all key processes in the pathogenesis of Parkinson's disease (PD). Polyunsaturated fatty acids (PUFAs) are important constituents of the synaptic and mitochondrial membranes and are often the first molecular targets attacked by reactive oxygen species (ROS). The rate-limiting step of the chain reaction of ROS-initiated PUFAs autoxidation involves hydrogen abstraction at bis-allylic sites, which can be slowed down if hydrogens are replaced with deuteriums. In this study, we show that targeted overexpression of human A53T α-syn using an AAV vector unilaterally in the rat substantia nigra reproduces some of pathological features seen in PD patients. Chronic dietary supplementation with deuterated PUFAs (D-PUFAs), specifically 0.8% D-linoleic and 0.3% H-linolenic, produced significant disease-modifying beneficial effects against α-syn-induced motor deficits, synaptic pathology, oxidative damage, mitochondrial dysfunction, disrupted trafficking along axons, inflammation and DA neuronal loss. These findings support the clinical evaluation of D-PUFAs as a neuroprotective therapy for PD.
Tighter process control and reduced cycle times using off-line recipe setup (2002)

To reduce work-in-process cycle time, engineering support time, and any measurement error in its process, Analog Devices has begun to implement off-line recipe creation. This allows the process engineers to create recipes long before the first lot of a new device gets to the factory floor, thus reducing "hot lot" cycle time, and improving process control through better recipe management. Now, all recipes for a given layer can be generated from the same template, eliminating differences caused by engineer-to-engineer variations in recipe set up. Engineering support time has been reduced and system availability has increased for recipes created in this manner, leaving more time for process engineers to pursue other projects. An added benefit is that process engineers are now able to schedule the time that they use to create recipes rather than being called to the metrology tool at random times to move a "hot lot".
Investigation of crystalline changes in LaRC‐TPI powders (1988)

Abstract Semicrystalline LaRC‐TPI is known to be capable of recrystallizing to higher melting crystalline forms upon initial melting. The behavior of these different crystalline forms has not been studied before. The present study uses techniques of differential scanning calorimetry and X‐ray diffractometry to investigate thes crystalline structural changes during recrystallization of this material. Semicrystalline LaRC‐TPIs synthesized from three different laboratories are included in this work.
Digestion Performance of Various Combinations of Thermophilic and Mesophilic Sludge Digestion Systems (2010)

Digestion Performance of Various Combinations of Thermophilic and Mesophilic Sludge Digestion SystemsVarious combinations of single and multi-stage anaerobic and aerobic/anaerobic digestion system were studied to evaluate their solids reduction potential along with capabilities to control sulfur based biosolids odor compounds. All the multi-staged digestion systems removed more volatile solids than the single stage anaerobic digestion systems even at the same overall detention time. However,...Author(s)Jongmin KimJohn T. NovakSourceProceedings of the Water Environment FederationSubjectSession 6: Sludge Minimization and Anaerobic DigestionDocument typeConference PaperPublisherWater Environment FederationPrint publication date Jan, 2010ISSN1938-6478SICI1938-6478(20100101)2010:4L.399;1-DOI10.2175/193864710802766949Volume / Issue2010 / 4Content sourceResiduals and Biosolids ConferenceFirst / last page(s)399 - 419Copyright2010Word count131Subject keywordsanaerobic digestionvolatile solid reductionvolatile organic sulfur compoundcombined aerobic-anaerobic digestion
Cover Image, Volume 116, Number 9, September 2019 (2019)

The cover image is based on the Review Nanoscale Integration of Single Cell Biologics Discovery Processes Using Optofluidic Manipulation and Monitoring by Marsela Jorgolli et al., https://doi.org/10.1002/bit.27024.