gebhart/patrepeval huggingface dataset:
Proteolytic processing of potyviral proteins and polyprotein processing intermediates in insect and plant cells (2002)

Processing of the polyprotein encoded by Potato virus A (PVA; genus Potyvirus) was studied using expression of the complete PVA polyprotein or its mutants from recombinant baculoviruses in insect cells. The time-course of polyprotein processing by the main viral proteinase (NIaPro) was examined with the pulse-chase method. The sites at the P3/6K1, CI-6K2 and VPg/NIaPro junctions were processed slowly, in contrast to other proteolytic cleavage sites which were processed at a high rate. The CI-6K2 polyprotein was observed in the baculovirus system and in infected plant cells. In both cell types the majority of CI-6K2 was found in the membrane fraction, in contrast to fully processed CI. Deletion of the genomic region encoding the 6K1 protein prevented proper proteolytic separation of P3 from CI, but did not affect processing of VPg, NIaPro, NIb or CP from the polyprotein. The 6K2-encoding sequence could be removed without any detectable effect on polyprotein processing. However, deletion of either the 6K1 or 6K2 protein-encoding regions rendered PVA non-infectious. Mutations at the 6K2/VPg cleavage site reduced virus infectivity in plants, but had a less pronounced, albeit detectable, effect on proteolytic processing in the baculovirus system. The results of this study indicate that NIaPro catalyses proteolytic cleavages preferentially in cis, and that the 6K1/CI and NIb/CP sites can also be processed in trans. Both 6K peptides are indispensable for virus replication, and proteolytic separation of the 6K2 protein from the adjacent proteins by NIaPro is important for the rate of virus replication and movement.
MIMO radar system using orthogonal complementary codes with Doppler offset (2017)

This paper proposes MIMO radar waveforms consisting of Doppler-offset orthogonal complementary codes (DO-OCC) for realizing high Doppler resilience in MIMO radar systems. The DO-OCC waveforms have low cross-correlation among multiplexed waves and a low autocorrelation peak sidelobe level (PSL) even in the Doppler shift condition. Through the experimental measurements by using 4 Tx-4 Rx MIMO radar system, it has been verified that the DO-OCC of the undesired signal power ratio (DUR) is over 45 dB, and the DO-OCC waveforms enable to maintain the direction of arrival (DOA) estimation accuracy for moving targets as almost same as the one for static targets. Consequently, our work has proven the effectiveness of the proposed MIMO waveforms to achieve Doppler tolerance while maintaining orthogonality and autocorrelation properties.
The Pause on Avian H5N1 Influenza Virus Transmission Research Should Be Ended (2012)

A voluntary 60-day pause on avian H5N1 influenza virus transmission research was announced in January 2012 by the international community of influenza scientists engaged in this work to provide time to explain the benefits of such work and the risk mitigation measures in place. Subsequently, the pause was extended to allow for time for review of the biosafety and biosecurity conditions. After almost 8 months, these conditions have been met in some countries and are close to being met in others. Because H5N1 virus transmission studies are essential for pandemic preparedness, researchers who have approval from their governments and institutions to conduct this research safely under appropriate biosecurity conditions should resume this important work.
Effect of End Groups on Mechanochromism and Electroluminescence in Tetraphenylethylene Substituted Phenanthroimidazoles (2016)

The design and synthesis of aggregation-induced emission (AIE) luminogens have attracted rapidly growing interest owing to the fundamental significance and diverse applications in mechanosensors, optical recording, security papers, and optoelectronic devices. In this contribution we report design and synthesis of four phenanthroimidazoles 3a–3d and explored their mechanochromic and electroluminescence properties. The phenanthroimidazoles 3a–3d were synthesized by Suzuki coupling reaction of iodophenathroimidazoles 2a–2d having different end groups (H, CH3, CF3, and CN) with 4-(1,2,2-triphenylvinyl)phenylboronic acid pinacol ester in good yields. The single crystal X-ray structures of 2b, 2c, 3a, and 3d are reported and show that the multiple phenyl rings in the TPE unit adopt nonplanar orientation. Their photophysical, aggregation induced emission (AIE), mechanochromic, electrochemical, and electroluminescence properties were studied. The phenanthroimidazoles 3a–3d exhibit strong AIE. High color contrast reversible mechanochromism between blue and green color was observed for phenanthroimidazoles 3a–3d. It was found that the solid state emission and mechanochromic behavior of tetraphenylethylene substituted phenanthroimidazoles 3a–3d are functions of the end group on phenanthroimidazole. In addition to the AIE and mechnochromic behavior, 3a and 3d compounds performed well as nondoped blue emitters in the organic light-emitting diodes by affording 3.9% and 4.0% external quantum efficiency, respectively.
Up to 20-Gb/s multilevel WDM PON transmitter based on self-seeded RSOAs (2015)

We propose a novel colourless self-tuning WDM PON multilevel transmitter based on self-seeding in two RSOAs co-located at the ONU in a two fold retracing circuit. We demonstrate its operation up to 20 Gb/s with BER below the FEC limit.
Denaturation and accelerated proteolysis of sizeable heme proteins by synthetic metalloporphyrins (2007)

A synthetic, copper porphyrin unwinds the α-helical domains of the heme proteins hemoglobin, myoglobin and cytochrome c, thereby catalysing trypsin-mediated proteolysis.
Figure S2 from Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer (2023)

&lt;p&gt;Aquaporin-7 dependent analysis of metabolomics and complex lipid profiling in cell lines and tumors.&lt;/p&gt;
Minimally Invasive Versus Open Ivor-Lewis Esophagectomy for Esophageal Cancer or Cancer of the Gastroesophageal Junction: Comparison of Postoperative Outcomes and Long-term Survival Using Propensity Score Matching Analysis (2021)

Our data suggest that MIE should be preferably performed in patients with esophageal cancer or cancer of the GEJ.
Bioactive natural products from two Sudanese medicinal plants Diospyros mespiliformis and Croton zambesicus. (2009)

Phytochemical investigations were performed in two plant species used in Sudanese traditional medicines to treat different illnesses, Diospyros mespiliformis and Croton zambesicus. The investigations revealed compounds of triterpenes (lupane series), one trihydroxyflavone and one diterpene. The compounds have been isolated and identified using various chromatographic and spectroscopic techniques. These were lupeol (1), betulinic acid (2), betulin (3) and lupenone (4) from Diospyros mespiliformis. Compounds 1, 2, 3 in addition to diterpene ent -kaurane-3β, 16β, 17-triol (5) and vitexin (6) were re-isolated from Croton zambesicus. However,compound 5 and 6 were isolated for the first time from this source.The pure isolated compounds and semi-synthesized acetates 1Ac, 2Ac and 3Ac, which were prepared from compounds 1, 2 and 3 respectively, were subjected to two bioassays: α- glucosidase enzyme inhibition assay and antioxidant activity. Compounds, 1, 1Ac, 3 and 4 showed a marked α-glucosidase inhibitory potential, while compound 6 exhibited strong antioxidant activity.
In-phase/quadrature skew measurement for optical Mach-Zehnder modulator (2017)

We propose an accurate and robust in-phase/quadrature (IQ) skew measurement method for optical Mach-Zehnder IQ modulator based on image spectrum analysis. Numerical simulation and experiment results demonstrate 0.7ps measurement accuracy. The robustness to bias deviations and finite extinction ratios were also investigated.
Next-Generation Lithography (2007)

The <i>Journal of Micro/Nanopatterning, Materials, and Metrology</i> (JM3) publishes peer-reviewed papers on the core enabling technologies that address the patterning needs of the electronics industry.
Hairpin dsRNA does not trigger RNA interference in Candida albicans cells (2010)

RNA interference/silencing mechanisms triggered by double-stranded RNA (dsRNA) have been described in many eukaryotes, including fungi. These mechanisms have in common small RNA molecules (siRNAs or microRNAs) originating from dsRNAs that, together with the effector protein Argonaute, mediate silencing. The genome of the fungal pathogen Candida albicans harbours a well-conserved Argonaute and a non-canonical Dicer, essential members of silencing pathways. Prototypical siRNAs are detected as members of the C. albicans transcriptome, which is potential evidence of RNA interference/silencing pathways in this organism. Surprisingly, expression of a dsRNA a hairpin ADE2 dsRNA molecule to interfere with the endogenous ADE2 mRNA did not result in down-regulation of the message or produce adenine auxotrophic strains. Cell free assays showed that the hairpin dsRNA was a substrate for the putative C. albicans Dicer, discounting the possibility that the nature of the dsRNA trigger affects silencing functionality. Our results suggested that unknown cellular events govern the functionality of siRNAs originating from transgenes in RNA interference/silencing pathways in C. albicans.
Directed Self-Assembly of Lamellar Microdomains of Block Copolymers Using Topographic Guiding Patterns (2009)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTDirected Self-Assembly of Lamellar Microdomains of Block Copolymers Using Topographic Guiding PatternsSang-Min Park, Charles T. Rettner, Jed W. Pitera, and Ho-Cheol Kim*View Author Information IBM Almaden Research Center, 650 Harry Road, San Jose, California 95120*To whom correspondence should be addressed: e-mail [email protected]; Tel 408-927-3725; Fax 408-927-3310.Cite this: Macromolecules 2009, 42, 15, 5895–5899Publication Date (Web):July 6, 2009Publication History Received24 March 2009Revised23 June 2009Published online6 July 2009Published inissue 11 August 2009https://pubs.acs.org/doi/10.1021/ma9006335https://doi.org/10.1021/ma9006335brief-reportACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views1157Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Copolymers,Lattices,Monte Carlo simulations,Thickness,Thin films Get e-Alerts
Ultrahigh-speed volumetric ophthalmic OCT imaging at 850nm and 1050nm (2010)

The performance and imaging characteristics of ultrahigh speed ophthalmic optical coherence tomography (OCT) are investigated.In vivo imaging results are obtained at 850nm and 1050nm using different configurations of spectral and swept source / Fourier domain OCT.A spectral / Fourier domain instrument using a high speed CMOS linescan camera with SLD light source centered at 850nm achieves speeds of ˜91,000 axial scans per second with ˜3um axial resolution in tissue.A spectral / Fourier domain instrument using an InGaAs linescan camera with SLD light source centered at 1050nm achieves ˜47,000 axial scans per second with ˜7um resolution in tissue.A swept source instrument using a novel wavelength swept laser light source centered at 1050nm achieves 100,000 axial scans per second.Retinal diseases seen in the clinical setting are imaged using the 91kHz 850nm CMOS camera and 47kHz 1050nm InGaAs camera based instruments to investigate the combined effects of varying speed, axial resolution, center wavelength, and instrument sensitivity on image quality.The novel 1050nm swept source / Fourier domain instrument using a recently developed commercially available short cavity laser source images at 100,000 axial scans per second and is demonstrated in the normal retina.The dense 3D volumetric data sets obtained with ultrahigh speed OCT promise to improve reproducibility of quantitative measurements, enabling early diagnosis as well as more sensitive assessment of disease progression and response to therapy.
11.3 A hybrid multipath CMOS magnetic sensor with 210µTrms resolution and 3MHz bandwidth for contactless current sensing (2016)

CMOS Hall sensors are widely used as magnetic sensors due to their linearity and ease of integration [1-3]. Being essentially n-well resistors, their resolution is determined by thermal noise and so decreases with bandwidth (Fig. 11.3.1), limiting their use in wide-band current-sensing applications, such as in switched-mode power supplies, electric motor control and short-circuit detection. In contrast, the differentiating characteristic of pick-up coils means that their resolution actually improves with bandwidth (Fig. 11.3.1). This paper describes a hybrid sensor in standard CMOS that achieves wide bandwidth and good resolution by employing a Hall sensor in a low-frequency (LF) path and a coil in a high-frequency (HF) path. The sensors' outputs are amplified by two transconductance amplifiers (gm,coil and gm,HS) and then combined by a transimpedance amplifier (TIA) (Fig. 11.3.1). The sensor achieves a resolution of 210μTrms in a 3MHz bandwidth; the latter represents an order of magnitude improvement over state-of-the-art CMOS magnetic sensors [1,4].
Molecular markers for diagnostic cytology of neoplasms in the head region of the pancreas: mutation of K-ras and overexpression of the p53 protein product. (1995)

The study indicates that assessment of alterations in the K-ras and p53 genes may be a valuable adjunct to diagnostic cytopathology of the head region of the pancreas, although there are some difficulties which will have to be overcome.
Changes in cytokines during treatment of elderly, hospitalized psychiatric patients – a naturalistic study (2019)

Immunological abnormalities have been demonstrated in several psychiatric disorders. Predominantly, studies have focused on younger adults, and research on elderly psychiatric in-patients is scant. In this naturalistic study, we investigated changes in cytokine levels during the treatment of diagnostically unselected elderly psychiatric in-patients, and whether these changes could be related to clinical outcomes. Clinical variables, demographic data, lifestyle data, and blood samples, including 27 plasma cytokines representing a broad spectrum of inflammatory mediators, were collected from 81 patients, 60 years and older, at admission and discharge. A subgroup of 49 patients also completed a self-reported clinical, psychiatric status form, indicating their level of recovery during hospitalisation. Statistical analyses demonstrated that a broad range of cytokines fell during treatment, and the fall was associated with clinical improvement, irrespective of psychiatric and somatic diagnoses. Exploiting cytokines as biomarkers of clinical traits might to be of limited use in a general population of elderly psychiatric in-patients as the field stands now.
Supercritical fluid technology: A reliable process for high quality BaTiO3 based nanomaterials (2014)

Ferroelectrics materials have been tremendously attractive since the 40 s with the discovery of ferroelectricity in metal oxide perovskite materials and more precisely in barium titanate. Due to their high potential for industrial applications, intensive research has been carried out to better understand their behavior and develop processes to produce them. Trying to face the down scaling demand of high quality particles towards the nanometer range, some conventional methods such as the solid state one reach their limits. The development of other processes are thus required and the synthesis in supercritical fluids can be considered as a promising alternative. This technology exhibits very interesting characteristics such as fast continuous synthesis (few seconds) of high quality nanoparticles (well crystallized nanoparticles with narrow size distribution) with controlled composition (Ba1−xSrxTiO3 with 0 ⩽ x ⩽ 1) at intermediate synthesis temperatures (<400 °C) with the use of non-toxic solvents (water, ethanol). Reaching the nanometer size range, the intrinsic properties of ferroelectric materials change compared to the bulk. Consequently a deep study concerning the crystalline structure, the presence of defects and the surface chemistry of those nanoparticles has to be achieved to control their properties for further use in functional devices.
Ecological footprint analysis of the circular industry of wheat fuel ethanol. (2010)

To improve the comparability of research results in circular industries,the ecological footprint(EF) method was applied to analyze the EF,resources recycling and reuse and environmental pollution emission among various subsystems,taking the wheat fuel ethanol industry as a case.The circular system of wheat fuel ethanol is made up of four subsystems,which are agriculture,ethanol production,circulation production and waste treatment.The results indicate that the prolonging of wheat fuel ethanol production chain will increase the EF,in which the EF of agriculture occupied the biggest area,because its proportion of farmland is very high in the subsystem of agriculture.It was found that the increase of EF follows the improving of economic benefit,meaning that the prolonging of production chain is of importance to resource utilization efficiency.The two subsystems of circulation production and waste treatment solve environmental pollution during the ethanol production process.The energy EF and water EF have high proportions in the system.It is suggested to reduce energy consumption and water consumption.The research shows that the EF is a good method to measure resource utilization and environmental pollution in various subsystems of circular industry.
Exploring Biosignatures Associated with Thenardite by Geomatrix-Assisted Laser Desorption/Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (GALDI-FTICR-MS) (2008)

Geomatrix-assisted laser desorption/ionization (GALDI) in conjunction with a Fourier transform ion cyclotron resonance mass spectrometer (FTICR-MS) has been employed to determine how effectively bio/organic molecules associated with the mineral thenardite (Na 2 SO 4 ) can be detected. GALDI is based on the ability of the mineral host to assist desorption and ionization of bio/organic molecules without additional sample preparation. When glycine was mixed with thenardite, glycine was deprotonated to produce C 2 H 4 NO 2 − at m/z 74.025. The combination of stearic acid with thenardite produced a complex cluster ion at m/z 390.258 in the negative mode, which was assigned a composition of C 18 H 39 O 7 Na−. A natural sample of thenardite from Searles Lake in California also produced a peak at m/z 390.260. The bio/organic signatures in both the laboratory-based and natural samples were heterogeneously dispersed as revealed by chemical imaging. The detection limits for the stearic acid and thenardite combination were estimated to be 3 parts per trillion or ∼7 zeptomoles (10 − 21 ) per laser spot. Attempts to improve the signal-to-noise ratio by co-adding FTICR-MS data predetermined to contain the biosignatures of interest revealed problems due to a lack of phase coherence between data sets.
Research highlights: surface-based microfluidic control (2015)

Microfluidic systems are often dominated by their surfaces because of the high surface area to volume ratios in microchannel flows or drop-based systems. Here we highlight recent work on engineering and exploiting surface effects to control the formation and motion of microdrops. We highlight work using precisely microstructured wetting surfaces to repel all manner of liquids even when the liquid-air surface tension is low. In a second paper, selective capillary filling and draining is used to pattern liquid and cell-laden gels for 3D culture. A final paper making use of vapor-driven surface tension effects to drive the motion of drop ensembles is also examined, exploring a new mechanism for drop control - including motion and merging. Surface-driven motion and patterning has been a widely successful area in microfluidics (e.g. electrowetting or patterned self-assembled monolayers) and recent work is extending into new directions that, once well-understood, should enable new applications.
Title: Preparing for the future (2010)

Given that current generation DWDM systems supported multiple bit rate upgrades, the expectation is that next generation platforms will provide even more scalability. This presentation focuses on key requirements to future proof the transport network.
Design of a Low Permanent Magnet Mass Hybrid Excited Flux Switching Machine for a PHEV Application (2017)

International audience
Efficient lineage tracking for scientific workflows (2008)

Data lineage and data provenance are key to the management of scientific data. Not knowing the exact provenance and processing pipeline used to produce a derived data set often renders the data set useless from a scientific point of view. On the positive side, capturing provenance information is facilitated by the widespread use of workflow tools for processing scientific data. The workflow process describes all the steps involved in producing a given data set and, hence, captures its lineage. On the negative side, efficiently storing and querying workflow based data lineage is not trivial. All existing solutions use recursive queries and even recursive tables to represent the workflows. Such solutions do not scale and are rather inefficient. In this paper we propose an alternative approach to storing lineage information captured as a workflow process. We use a space and query efficient interval representation for dependency graphs and show how to transform arbitrary workflow processes into graphs that can be stored using such representation. We also characterize the problem in terms of its overall complexity and provide a comprehensive performance evaluation of the approach.
Effect of electrode size on impedance images of two- and three-dimensional objects (1998)

The sensitivity of an impedance imaging system to small cylindrical inhomogeneities in two-dimensional (2-D) and three-dimensional (3-D) saline tanks was studied for different height electrodes and different height targets. Experimental results were compared with analytical models. Inhomogeneities in the 3-D tank having limited vertical extent were detected by electrodes of vertical size comparable to that of the inhomogeneity. Taller electrodes had increased sensitivity to short targets to only a limited extent. When the electrode height was more than twice that of the target, sensitivity decreased or remained the same with further increases in electrode height. The system was less sensitive to inhomogeneities in the 3-D tank than to those in the 2-D tank. The distinguishability of conductors was greater than that of insulators in the 3-D tank, and the opposite was true in the 2-D tank, consistent with an analytical result.