gebhart/patrepeval huggingface dataset:
Ship-in-a-Bottle Synthesis of High Concentration of N2 Molecules in a Cage-Structured Electride (2021)

We report the formation of neutral nitrogen molecules in the cages of [Ca<sub>12</sub>Al<sub>14</sub>O<sub>32</sub>]<sup>2+</sup> (C12A7) framework compensated by extra-framework anions. NH<sub>3</sub> treatment of C12A7 electride (C12A7:<i>e</i><sup>-</sup>) at 800 °C leads to the formation of N<sub>2</sub> and NH<sup>2-</sup> species in the C12A7 cages. N<sub>2</sub> and NH<sub><i>x</i></sub> species in the cages are identified using the Raman spectroscopy of <sup>14</sup>NH<sub>3</sub> and <sup>15</sup>NH<sub>3</sub>-treated C12A7:<i>e</i><sup>-</sup>. The concentration of H and N in the C12A7 cages after NH<sub>3</sub> treatment is ∼10<sup>21</sup> cm<sup>-3</sup>. We propose a two-step mechanism, supported by density functional theory (DFT) modeling, of N<sub>2</sub> incorporation into the C12A7 cages, i.e., incorporation of NH<sup>2-</sup> formed from decomposition of NH<sub>3</sub> at C12A7:<i>e</i><sup>-</sup> surface followed by the NH<sup>2-</sup> species reacting to form N<sub>2</sub> molecules. Encapsulation of neutral molecules, as opposed to negatively charged species reported in C12A7 previously, offers new opportunities for trapping and storing gaseous substances in nanoporous materials.
The Evaluation of the 1980 Decennial Census (1980)

Barbara A. Bailar, Charles D. Jones, The Evaluation of the 1980 Decennial Census, Journal of the Royal Statistical Society. Series D (The Statistician), Vol. 29, No. 4, Proceedings of the 1980 I.O.S. Annual Conference on Censuses and Sample Surveys (Dec., 1980), pp. 223-235
Orthogonal Cover Code Design for 802.11be Extremely High Throughput WLANs (2019)

This paper describes designs of orthogonal cover codes for the physical layer preamble of 802.11be packets, and discusses their merits and advantages. The IEEE Standards Association has formed the 802.11be Task Group to develop an amendment called Extremely High Throughput, which shall supersede 802.11ax. Among the main new features are support for MIMO with up to 16 spatial streams, 320 MHz channel bandwidth and joint transmission from multiple access points. The 802.11 standard specifies a set of orthogonal matrices, often called P matrices, which are employed as orthogonal cover codes for the so-called Long Training Fields which are used for MIMO channel estimation. Since 802.11ax only supports up to 8 spatial streams, and since joint transmission also requires support for more than 8 transmitter chains, the standardization of new P matrices is necessary. This work presents new P matrices of even order greater than 8 which are well suited for efficient digital implementations.
Physicochemical and Interfacial Investigation of Lipid/Polymer Particle Assemblies (2005)

A model study was investigated to develop colloidal supramolecular assemblies consisting of particles coated with lipid layers. The interactions between monodisperse sulfate-charged poly(styrene) submicrometer particles and zwitterionic/cationic lipid vesicles composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and 1,2-dipalmitoyl-3-trimethylammonium propane were considered. The influence of relevant experimental parameters on the final associations was examined by quasi-elastic light scattering to point out some new phenomena occurring in these colloidal systems. The major role of electrostatic interactions as driving forces to control the organization between cationic lipids and oppositely charged poly(styrene) particles was clearly evident, whereas this influence was less pronounced when considering the zwitterionic lipids. The characterization of these original complex assemblies was completed by a thorough study of the surface modification. The combination of zeta potential measurements, X-ray photoelectron spectroscopy analyses, and microscopy observations proved that the envisioned model can really correspond to polymer particles surrounded by lipids.
Biological Effect of Hydrolyzed Collagen on Bone Metabolism (2015)

Osteoporosis is a chronic and asymptomatic disease characterized by low bone mass and skeletal microarchitectural deterioration, increased risk of fracture, and associated comorbidities most prevalent in the elderly. Due to an increasingly aging population, osteoporosis has become a major health issue requiring innovative disease management. Proteins are important for bone by providing building blocks and by exerting specific regulatory function. This is why adequate protein intake plays a considerable role in both bone development and bone maintenance. More specifically, since an increase in the overall metabolism of collagen can lead to severe dysfunctions and a more fragile bone matrix and because orally administered collagen can be digested in the gut, cross the intestinal barrier, enter the circulation, and become available for metabolic processes in the target tissues, one may speculate that a collagen-enriched diet provides benefits for the skeleton. Collagen-derived products such as gelatin or hydrolyzed collagen (HC) are well acknowledged for their safety from a nutritional point of view; however, what is their impact on bone biology? In this manuscript, we critically review the evidence from literature for an effect of HC on bone tissues in order to determine whether HC may represent a relevant alternative in the design of future nutritional approaches to manage osteoporosis prevention.
Omarigliptin (MARIZEV™,MK‐3102) (2018)

The manufacturing synthesis of omarigliptin used an improved convergent scheme. The original convergent synthesis of omarigliptin involved the coupling of methylsulfonylpyrrolopyrazole 14 and tetrahydropyranone 22. The omarigliptin used for clinical trials was a white crystalline material (confirmed by optical microscopy and X-ray powder diffraction (XRPD)). This chapter presents key physicochemical properties of omarigliptin. In clinical studies omarigliptin was shown to have a biphasic pharmacokinetic (PK) profile with a terminal half-life of 120 h that is adequate for once-weekly dosing. In the corresponding pharmacodynamic (PD) assay, omarigliptin-mediated plasma dipeptidylpeptidase-4 (DPP-4) inhibition and plasma compound concentrations were dose dependent. A counter screen evaluation in 168radio ligand binding and enzymatic assays at MDS Pharma confirmed the compound's selectivity as a DPP-4 inhibitor. Exposure to omarigliptin shows linear PK with respect to time and dose proportional at dose range between 10 and100 mg.
Robustaflavone, a potential non-nucleoside anti-hepatitis B agent (1998)

Robustaflavone, a naturally occurring biflavanoid isolated from Rhus succedanea, was found to be a potent inhibitor of hepatitis B virus (HBV) replication in 2.2.15 cells, with an effective concentration (EC50) of 0.25 microM, and a selectivity index (SI, IC50/EC90) of 153. Robustaflavone hexaacetate inhibited HBV replication with an EC50 of 0.73 microM, but exhibited no cytotoxicity at concentrations up to 1000 microM. Combinations of robustaflavone with penciclovir and lamivudine displayed synergistic anti-HBV activity, having the most pronounced effects when the combination ratios were similar to the ratio of EC50 potencies. Thus, a 1:1 combination of robustaflavone and penciclovir exhibited an EC50 of 0.11 microM and an SI of 684, while a 10:1 combination of robustaflavone and lamivudine exhibited an EC50 of 0.054 microM and an SI of 894. Statistical analyses of the combination data using the Combostat program confirmed that robustaflavone exhibited synergism with both penciclovir and lamivudine.
Thermodynamic Analysis of Binding between Mouse Major Urinary Protein-I and the Pheromone 2-sec-Butyl-4,5-dihydrothiazole (2003)

The mouse pheromone 2-sec-butyl-4,5-dihydrothiazole (SBT) binds to an occluded, nonpolar cavity in the mouse major urinary protein-I (MUP-I). The thermodynamics of this interaction have been characterized using isothermal titration calorimetry (ITC). MUP-I-SBT binding is accompanied by a large favorable enthalpy change (DeltaH = -11.2 kcal/mol at 25 degrees C), an unfavorable entropy change (-TDeltaS = 2.8 kcal/mol at 25 degrees C), and a negative heat capacity change [DeltaC(p)() = -165 cal/(mol K)]. Thermodynamic analysis of binding between MUP-I and several 2-alkyl-4,5-dihydrothiazole ligands indicated that the alkyl chain contributes more favorably to the enthalpy and less favorably to the entropy of binding than would be expected on the basis of the hydrophobic desolvation of short-chain alcohols. However, solvent transfer experiments indicated that desolvation of SBT is accompanied by a net unfavorable change in enthalpy (DeltaH = +1.0 kcal/mol) and favorable change in entropy (-TDeltaS = -1.8 kcal/mol). These results are discussed in terms of the possible physical origins of the binding thermodynamics, including (1) hydrophobic desolvation of both the protein and the ligand, (2) formation of a buried water-mediated hydrogen bond network between the protein and ligand, (3) formation of strong van der Waals interactions, and (4) changes in the structure, dynamics, and/or hydration of the protein upon binding.
The Case for HER2/neu as a Therapeutic Target for Gynecologic Malignancies (2012)

Evaluation of: Guzzo F, Bellone S, Buza N et al. HER2/neu as a potential target for immunotherapy in gynecological carcinosarcomas. Int. J. Gynecol. Pathol. 31, 211-221 (2012). Trastuzumab (Herceptin(®)) is a human monoclonal antibody that is US FDA-approved for the treatment of HER2/neu-overexpressing breast cancer and metastatic gastric cancer. HER2/neu expression has also been observed in other malignancies, notably in subsets of endometrial and ovarian cancers, raising the possibility that trastuzumab may be a viable treatment option in these settings. The current paper reveals that HER2/neu may also be expressed in gynecologic carcinosarcomas, which are rare but aggressive tumors with a high rate of resistance to chemotherapy. Cell lines derived from ovarian carcinosarcomas expressed HER2/neu and were sensitive to trastuzumab ADCC. By contrast, cell lines derived from uterine carcinosarcomas were HER2/neu-negative and insensitive to trastuzumab ADCC. These observations indicate that at least a subset of gynecologic carcinosarcoma patients may benefit from trastuzumab treatment. However, trastuzumab monotherapy typically has relatively low response rates, which in part may be related to impaired NK cell function in patients with advanced disease. Accordingly, treatments that boost NK cell activity may improve response rates to trastuzumab treatment, not only for gynecologic carcinosarcomas, but also for other HER2/neu-positive malignancies.
Superposition-based Modelling of Series FACTS in Nonlinear Mathematical Optimized Grid Operation (2020)

Ongoing changes in electrical energy systems and increasing possibilities to control power flows increase volatility as well as flexibility and therefore complexity of their operation. Hence, systems for power flow control, system optimization, and their efficient integration in system operation and planning currently are researched. Especially for grid operation, reproducible and robust solutions are needed which can be provided by mathematical optimizations. This work describes a novel approach to flexibly and efficiently integrate different series FACTS and compensation elements with just one common equivalent circuit in a nonlinear mathematical optimization framework. The superposition-inspired modelling approach divides pi-line and series element power flows in order to easily implement series elements in the proposed power flow description. The presented implementation allows to model different elements while keeping the node-admittance matrix constant and to include equipment-specific control structures and constraints in the optimization framework. The implementation is validated compared to a detailed modelling in a reference simulation environment. In different applications of the novel modelling a reduction of losses over 14 % even in a small test system can be achieved, while a second application example highlights the importance of optimization with system-wide views compared to local set-point controls.
Transformationsorientierte Software (2004)

No AccessSoftware EngineeringOct 2004Transformationsorientierte SoftwareGustav Pomberger, Wolfgang PreeGustav Pomberger, Wolfgang Preehttps://doi.org/10.3139/9783446227880.007SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2004Pages: 181-216Print ISBN: 978-3-446-22429-2eISBN: 978-3-446-22788-0 Copyright & Permissions© 2004 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Perioperative and Delayed Major Complications Following Surgical Treatment of Adolescent Idiopathic Scoliosis (2017)

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
SDN-enabled sliceable BVT based on multicarrier technology for multi-flow rate/distance and grid adaptation (2015)

We experimentally demonstrate multiple advanced functionalities of a cost-effective high-capacity sliceable-BVT using multicarrier technology. It is programmable, adaptive and reconfigurable by an SDN controller for efficient resource usage, enabling unique granularity, flexibility and grid adaptation, even in conventional fixed-grid networks.
Modification of residual vibrations in elevators with time-varying cable lengths (2002)

Residual vibration in high-rise elevators remains an important issue. Our earlier work on this problem assumed fixed cable lengths. In this paper, we present a dynamic model of the elevator where the cable lengths are changing with time. The elevator car is modeled as a rigid body connected by two flexible cables. An elegant approach is presented here to modify the residual vibrations using the theory of /spl delta/-flatness. Collocation method is used to calculate the inputs required by the motors mounted at the ends of the two cables to modify the residual vibration. The approach is demonstrated by numerical simulation. An experiment is planned in. the near future to validate the theoretical results.
Electrophoretic Characterization of Spring Spelt Wheat Gliadins (1996)

Gliadin compositions of 95 spring spelts, 5 winter spelts, and Neepawa Hard Red Spring (HRS) wheat were evaluated by acid−polyacrylamide gel electrophoresis (A-PAGE). Five spring spelts grown in three environments over 2 years were compared to the HRS cultivar Katepwa using A-PAGE and sodium dodecyl sulfate−polyacrylamide gel electrophoresis (SDS-PAGE). On the basis of the scoring of 13 bands, the spring and winter spelts diverged widely from Neepawa HRS wheat. None of the spring spelts evaluated had a gliadin protein profile identical to that of commercially available winter spelt. Spring and winter spelts were differentiated from Katepwa HRS wheat based on ω-gliadin composition, in which common wheat was characterized by the presence of a slow-moving ω-gliadin and a strong-staining fast-moving ω-gliadin. Common wheat and spring spelt accessions SK0505, SK0263, and RL5407 (black-hulled spelts) had a distinct strong band in the γ-gliadin region with MW of about 64K which was absent in winter spelts and the spring spelts SK0021 and PGR8801 (white-hulled spelts). The molecular weights of gliadin proteins were in the range of 34K−75K. Keywords: Spelt; wheat; gliadin; electrophoresis; A-PAGE; SDS-PAGE, NTSYS-PC
Electrochemical and XPS Studies toward the Role of Monomeric and Polymeric Sulfonate Counterions in the Synthesis, Composition, and Properties of Poly(3,4-ethylenedioxythiophene) (2003)

Electrochemically prepared poly(3,4-ethylenedioxythiophene) (PEDT) poly(styrenesulfonate) (PSS), produced from acidic (PSSH) and basic (PSSNa) PSS, was characterized by cyclic voltammetry CV, UV−vis spectroscopy, in situ conductivity, and XPS spectroscopy and was compared with electrochemically prepared PEDT/tosylate and chemically prepared PEDT/PSS. CV analysis shows that the polymer synthesis is strongly affected by the nucleophilic character of the counteranion. Although CV and UV−vis spectroscopy show that the structure and degree of polymerization (oligomeric, ca. 10 EDT units) of the PEDT backbone is the same for all polymers, XPS is able to explain the different conductivity values for these materials (ranging from 1 S cm-1 for PEDT/PSSNa to 400−450 S cm-1 for PEDT/tosylate) based on doping level and composition. In particular, critical results are observed to be the ratios between sulfonate and thiophene units in the polymers: the higher the PEDT concentration, the higher the conductivity. XPS also explains by solvent-induced nanometer-scale segregation between PEDT/PSS and excess PSS particles the often reported conductivity enhancement of chemically prepared PEDT/PSS upon treatment with polar solvents.
Abstract IA001: Evidence for a ‘pathway tuning’ model of VHL-associated renal carcinoma (2023)

Abstract In clear cell renal carcinoma (RCC), the hypoxia inducible factor (HIF) transcriptional response is unphysiologically activated by mutations that impair or inactivate the von Hippel-Lindau tumour suppressor, which normally acts as a ubiquitin E3 ligase promoting the oxygen dependent proteolysis of hypoxia inducible factor (HIF). The lecture will review evidence for pro- and anti-tumourigenic actions arising from different components of HIF pathway activation in the setting of VHL-associated RCC. This includes evidence from genome-wide association studies (GWAS) that demonstrate a striking association of GWAS signals with cis-acting sequences in the HIF transcriptional system. This supports a ‘pathway tuning’ model in which multiple small selective effects are important in enabling cancer progression in the face of unphysiological activation of very extensive biological pathways. To assess this hypothesis a new experimental model has been developed, which enables the precise tracking of Vhl-inactivated cells. Results on the temporal and spatial effects of Vhl inactivation in kidneys will be presented. Citation Format: Peter J. Ratcliffe. Evidence for a ‘pathway tuning’ model of VHL-associated renal carcinoma [abstract]. In: Proceedings of the AACR Special Conference: Advances in Kidney Cancer Research; 2023 Jun 24-27; Austin, Texas. Philadelphia (PA): AACR; Cancer Res 2023;83(16 Suppl):Abstract nr IA001.
Differential expression of the H‐ras mutated and normal alleles in rabbit dmba‐induced keratoacanthomas (1995)

Keratoacanthomas (KAs) are benign and self-regressing tumors in which a high incidence of the mutated H-ras oncogene has been observed both in humans and in experimental models. To determine the level of expression of the mutated H-ras allele with respect to its normal counterpart in 7,12-dimethylbenz(a)anthracene (DMBA)-induced KAs in rabbit skin, we have utilized a quantitative technique based on reverse transcription polymerase chain reaction (RT-PCR) and selective cleavage of the mutated molecules of the H-ras gene. Analysis of 16 KAs showed that the mutated H-ras transcripts were up to 3-fold more abundant than the non-mutated H-ras transcript in the different tumors. This higher expression of the mutated allele appears to correlate with increased differentiation in the KAs and in turn may contribute to tumor regression.
HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo (2003)

Mouse long-term hematopoietic reconstituting cells exist in the c-Kit+Sca-1+Lin- (KSL) cell population; among them, CD34(low/-) cells represent the most highly purified population of hematopoietic stem cells in the adult bone marrow. Here, we demonstrate that retrovirus-mediated transduction of CD34(low/-)c-Kit+Sca-1+Lin- (34-KSL) cells with the HES-1 gene, which encodes a basic helix-loop-helix transcription factor functioning downstream of the Notch receptor, and is a key molecule for the growth phase of neural stem cells in the embryo, preserves the long-term reconstituting activity of these cells in vitro. We also show that cells derived from the HES-1-transduced 34-KSL population produce progenies characterized by negative Hoechst dye staining, which defines the side population, and by CD34(low/-) profile in the bone marrow KSL population in each recipient mouse at ratios 3.5- and 7.8-fold those produced by nontransduced 34-KSL-derived competitor cells. We conclude that HES-1 preserves the long-term reconstituting hematopoietic activity of 34-KSL stem cells ex vivo. Up-regulation of HES-1 protein in the 34-KSL population before unnecessary cell division, that is, without retrovirus transduction, may represent a potent approach to absolute expansion of hematopoietic stem cells.
"Pop-up" display wth 3-dimensional microlens structures (2005)

In this paper, we demonstrate a display. This display provides a pop-up image in the air with double-layered plane-convex microlenses and a hole array. This microlens array is fabricated by melting photoresists and form transfer as stated in A. Schilling et al. (2000) and A. Nakai et al. (2002). The height and diameter of the microlens was 34.6 /spl mu/m and 198 /spl mu/m, therefore the focal length was calculated as 318 /spl mu/m. To inspect the pop-up length, we estimated the position of the focal plane by measuring the light intensity of the image. The image was formed at 2750 /spl mu/m higher from the original image on the display. In addition, we proved that the lens part needs no alignment with the original image.
Self-Driven Graph Volterra Models for Higher-Order Link Prediction (2020)

Link prediction is one of the core problems in network and data science with widespread applications. While predicting pairwise nodal interactions (links) in network data has been investigated extensively, predicting higher-order interactions (higher-order links) is still not fully understood. Several approaches have been advocated to predict such higher-order interactions, but no principled method has been put forth to tackle this challenge so far. Cross-fertilizing ideas from Volterra series and linear structural equation models, the present paper introduces self-driven graph Volterra models that can capture higher-order interactions among nodal observables available in networked data. The novel model is validated for the higher-order link prediction task using real interaction data from social networks.
The first Belgian series of 56 patients with congenital hypogonadotropic hypogonadism (CHH): genetic and brain abnormalities (2018)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
On the Critical Issues of DSP/FPGA Mixed Digital Predistorter Implementation (2006)

This paper describes the hardware platform and the digital signal processing algorithms that form an integrated test bench used for a mixed DSP/FPGA implementation of a digital baseband predistorter for broadband wireless transmitters. In this work, a digital signal processor (DSP) exploits the digital input and output waveforms of the transmitter in order to synthesize the adequate pre-distortion function. This latter, running in real-time on the FPGA, adjusts the baseband signals accordingly in order to insure a transmitter signal output almost free of out-of-band emission along with a low error vector magnitude (EVM). Several critical issues related to the implementation of such digital pre-distorter are reported and discussed.