gebhart/patrepeval huggingface dataset:
Derivatives of Heteroarylsulfonamides, Their Preparation, and Their Application in Human Therapy (2012)

ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTDerivatives of Heteroarylsulfonamides, Their Preparation, and Their Application in Human TherapyPatent HighlightBenjamin Blass*View Author Information Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, United States*Tel: 215-707-1085. E-mail: [email protected]Cite this: ACS Med. Chem. Lett. 2012, 3, 8, 618–619Publication Date (Web):July 2, 2012Publication History Published online2 July 2012Published inissue 9 August 2012https://pubs.acs.org/doi/10.1021/ml3001598https://doi.org/10.1021/ml3001598editorialACS PublicationsCopyright © 2012 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views757Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (224 KB) Get e-AlertscloseSUBJECTS:Alkyls,Ions,Potassium,Reaction products,Therapeutics Get e-Alerts
Spray‐Dried Soy Protein Isolate Solubility, Gelling Characteristics, and Extractable Protein as Affected by Antioxidants (1995)

ABSTRACT With the addition of antioxidants, spray‐dried soy protein isolates (SPI) exhibited increased solubilities by 8% over the control in 0.1M NaCl. Increased solubilities corresponded to a 15% and 8% reduction in protein oxidation as determined by protein carbonyl contents. The greatest differences in solubility between a spray‐dried SPI with antioxidant (66% protein solubility) and the control (54% protein solubility), as well as the minimum protein solubility, occurred in 0.2M NaCl. Following the initial solubilization step in SPI processing, amount of extracted proteins was increased by 4.5% over the control with addition of antioxidants. Gel fracturability, hardness and adhesiveness for heat set gels of 12% SPI processed with added antioxidants were increased by 26.3%, 23.5% and 24.6%, respectively.
TEST AND EVALUATION OF ARIZONA SLIP-AWAY BASE LUMINAIRE SUPPORTS. FINAL REPORT (1994)

A study was undertaken to evaluate the impact performance of the Arizona Department of Transportation's (ADOT's) slip-away base luminaire supports. For purposes of this evaluation, three full-scale crash tests were conducted in accordance with the requirements of NCHRP Report 350. During this test program, ADOT's 13.7-m (45-ft) constant tapered luminaire support was found to exhibit unacceptable impact performance. Although the slip base activated readily and the occupant impact velocity was within recommended limits, a secondary impact of the pole with the roof of the vehicle resulted in substantial deformation of the roof structure. A subsequent test of ADOT's standard 12.2-m (40-ft) luminaire system was judged to be marginally acceptable. Although the luminaire support readily yielded to the vehicle and the occupant risk criteria were well within the recommended limits established by NCHRP Report 350, the test vehicle once again sustained substantial deformation to the roof structure from a secondary impact with the luminaire pole. However, the magnitude and localized extent of the crush was judged to be within acceptable limits based on results of other approved systems. Several candidate systems were identified which provide a mounting height of 13.7 m (45 ft) or greater and which could serve as replacements for ADOT's deficient 13.7-m (45-ft) poles. The most promising of these is a steel 4-bolt slip-base design developed by the Utah Department of Transportation (UDOT) which has a mounting height of 15.8 m (52 ft) and was successfully crash tested. As an alternative to adopting a new design, it is also recommended that the current design requirements be carefully reviewed and options for reducing the weight of the existing system be considered. Maintenance practices related to slip-bolt torque were also reviewed. Although no specific post-installation inspection procedure for slip-base bolt torques is offered at this time, periodic visual inspections of slip-base poles should be considered to determine if debris, soil, corrosion, erosion, or other hindrances that could compromise proper actuation of the slip-base are present. It was also noted that although proper performance of slip-base supports depends on the clamping force in the slip-base bolts, crash tests and analytical studies indicate that the performance is not overly sensitive to the clamping force.
An Indirect Impedance Technique to Detect Corrosion in Structural Bridge Tendons (2018)

Abstract An indirect impedance technique is assessed as a possible method to detect corrosion within external post-tensioned bridge tendons. The indirect impedance aims to extract the impedance of the steel-grout interface from the impedance measured at the surface of the grout. However, the electrode configuration required for the indirect impedance measurement yields geometry-induced frequency dispersion that confounds interpretation. A proof of concept was established for using indirect impedance to detect corrosion in post-tensioned tendons. Bench-top experiments were performed to show that the indirect impedance was sensitive to the properties of the steel and grout interface. Finite-element models were used to simulate the indirect impedance and determine how the geometry of the unusual electrode configuration influences the impedance. The indirect impedance was able to distinguish between locations of corroding steel and locations of passive steel, even if the actual damage to the steel was minimal. However, the complex nature of the grout impedance limits the indirect impedance measurement to providing only a qualitative assessment of the corrosion of bridge tendons.
Dataset creation pipeline for camera-based heart rate estimation (2023)

Heart rate is one of the most vital health metrics which can be utilized to investigate and gain intuitions into various human physiological and psychological information.Estimating heart rate without the constraints of contact-based sensors thus presents itself as a very attractive field of research as it enables well-being monitoring in a wider variety of scenarios.Consequently, various techniques for camera-based heart rate estimation have been developed ranging from classical image processing to convoluted deep learning models and architectures.At the heart of such research efforts lies health and visual data acquisition, cleaning, transformation, and annotation.In this paper, we discuss how to prepare data for the task of developing or testing an algorithm or machine learning model for heart rate estimation from images of facial regions.The data prepared is to include camera frames as well as sensor readings from an electrocardiograph sensor.The proposed pipeline is divided into four main steps, namely removal of faulty data, frame and electrocardiograph timestamp dejittering, signal denoising and filtering, and frame annotation creation.Our main contributions are a novel technique of eliminating jitter from health sensor and camera timestamps and a method to accurately time align both visual frame and electrocardiogram sensor data which is also applicable to other sensor types.
The assessment of atrial function by velocity-encoded magnetic resonance imaging (2013)

Introduction: The purpose of this study was to assess velocity-encoded cardiac magnetic resonance imaging (Ve-CMR) in a population of patients referred for cardiac magnetic resonance imaging (CMR), to determine the variability of atrial function, and to identify clinical parameters associated with left atrial function. Methods: This is a prospective study evaluating patients who were referred to our CMR center for a clinical CMR. Left atrial function was obtained via Ve-CMR thru-plane images across the mitral valve after acquiring 2 perpendicular in-plane images as “scouts”. The atrial function and mitral inflow were quantified by computer analysis (Argus, Siemens). Atrial function was defined as atrial contraction (A-wave) volume divided by total inflow volume. Left atrial volumes were calculated via computer analysis. Mitral regurgitation and left ventricular ejection fractions were assessed visually. Results: Thirty-nine patients, with mean age 56 +/- 10 years, were enrolled. The mean left atrial function was 22.9% +/-14.5%; the range in left atrial function was 0% - 57%. There was a significant positive correlation between atrial function and increased left ventricular ejection fraction (r = 0.44, P
Combined ion-mobility and mass-spectrometry investigations of metallothionein complexes using a tandem mass spectrometer with a segmented second quadrupole (2005)

Rabbit metallothionein (MT) 2A complexes with Cd(II), Zn(II), Ag(I), Cu(I), Hg(II), arsenite, monomethylarsonous acid (MMA), and dimethylarsinous acid (DMA) have been examined using ion-mobility measurements and mass spectrometry in a triple-quadrupole mass spectrometer equipped with a segmented second quadrupole that doubled as an ion-mobility cell [Guo, Y.; Wang, J.; Javahery, G.; Thomson, B. A.; Siu, K. W. M. An Ion-Mobility Spectrometer with Radial Collisional Focusing. Anal. Chem.2005, 77, 266-275]. The metal ions confer conformational rigidity on the MT complexes, which counteracts Coulombic repulsion among protons added as a result of electrospray. Triply and quadruply protonated Cd(7)MT2A have smaller cross-sections than the Cd(7)MT2A structure deduced from published NMR data. For the 6+ ions, the As(6)MT2A complex has a cross-section of 790 A(2); the MMA(10)MT2A complex, 920 A(2); and the DMA(20)MT2A complex, 1220 A(2). This increase in cross-section of the As(III) species, from As(3+) to MMA to DMA, is interpreted as a consequence of decreasing multiple coordination and increasing number of methyl groups.
Characterization of 2-Methyl-4-amino-5-(2-methyl-3-furylthiomethyl)pyrimidine from Thermal Degradation of Thiamin (2002)

Thiamin hydrochloride was thermally degraded in phosphate buffer (pH 6.5) at 110 degrees C for 2 h. A major decomposition product was isolated by column chromatography and structurally identified by spectrometric techniques ((1)H NMR, (13)C NMR, 2D NMR, and MS) as 2-methyl-4-amino-5-(2-methyl-3-furylthiomethyl)pyrimidine (MAMP). The possible formation pathway of MAMP was studied using two model systems. It is proposed that MAMP is formed by nucleophilic attack of 2-methyl-3-furanthiol on the thiamin.
Borehole deviation surveys are necessary for hydraulic fracture monitoring (2006)

Not performing accurate borehole deviation surveys for hydraulic fracture monitoring (HFM) and neglecting the effects of the borehole trajectory results in significant errors in the calculated fracture azimuth and other parameters. For common HFM geometries, a 5° deviation uncertainty of monitoring or treatment wells can cause more than 40° uncertainty in inverted fracture azimuths. Furthermore, if the positions of injection point and receiver array are not known accurately and the velocity model is artificially adjusted to locate fracture on an assumed injection point, several milliseconds discrepancy between measured and modelled P‐to‐S‐wave travel‐times may appear at utmost receivers of the receiver array. This travel‐time discrepancy may then be misinterpreted as VTI anisotropy. In the case of HFM, the uncertainty of the relative positions between the monitoring and treatment wells can have a cumulative, non‐linear effect on inverted fracture parameters.
Water–solid contact electrification causes hydrogen peroxide production from hydroxyl radical recombination in sprayed microdroplets (2022)

Contact electrification between water and a solid surface is crucial for physicochemical processes at water-solid interfaces. However, the nature of the involved processes remains poorly understood, especially in the initial stage of the interface formation. Here we report that H<sub>2</sub>O<sub>2</sub> is spontaneously produced from the hydroxyl groups on the solid surface when contact occurred. The density of hydroxyl groups affects the H<sub>2</sub>O<sub>2</sub> yield. The participation of hydroxyl groups in H<sub>2</sub>O<sub>2</sub> generation is confirmed by mass spectrometric detection of <sup>18</sup>O in the product of the reaction between 4-carboxyphenylboronic acid and <sup>18</sup>O-labeled H<sub>2</sub>O<sub>2</sub> resulting from <sup>18</sup>O<sub>2</sub> plasma treatment of the surface. We propose a model for H<sub>2</sub>O<sub>2</sub> generation based on recombination of the hydroxyl radicals produced from the surface hydroxyl groups in the water-solid contact process. Our observations show that the spontaneous generation of H<sub>2</sub>O<sub>2</sub> is universal on the surfaces of soil and atmospheric fine particles in a humid environment.
Static Secondary Ion Mass Spectrometry (SSIMS) (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Practical Fractional-Order Variable-Gain Super-Twisting Control with Application to Wafer Stages of Photolithography Systems (2021)

In this paper, a practical fractional-order variable-gain super-twisting algorithm (PFVSTA) is proposed to improve the tracking performance of wafer stages for semiconductor manufacturing. Based on the sliding mode control (SMC), the proposed PFVSTA enhances the tracking performance from three aspects: 1) alleviating the chattering phenomenon via super-twisting algorithm and a novel fractional-order sliding surface~(FSS) design, 2) improving the dynamics of states on the sliding surface with fast response and small overshoots via the designed novel FSS and 3) compensating for disturbances via variable-gain control law. Based on practical conditions, this paper analyzes the stability of the controller and illustrates the theoretical principle to compensate for the uncertainties caused by accelerations. Moreover, numerical simulations prove the effectiveness of the proposed sliding surface and control scheme, and they are in agreement with the theoretical analysis. Finally, practice-based comparative experiments are conducted. The results show that the proposed PFVSTA can achieve much better tracking performance than the conventional methods from various perspectives.
[Intentional peer support]. (2014)

In this paper, we will describe the core themes behind the practice of Intentional Peer Support (IPS), offering a unique perspective on what has commonly been described as "mental illness" and the power dynamics inherent in traditional helping relationships. Through intentional conversations that explore "how we've come to know what we know" and challenge the naming of our experience by others, we begin to find new ways of understanding and responding to our own and other people's experiences. In addition, we emphasize the importance of mutuality in relationships. Both people share responsibility for the relationship, and no one is assumed to be the sole holder of "truth". Mutuality becomes harder but even more critical to practice when we begin to fear for "safety" of the other. It is our belief that as we practice IPS across all relationships in our lives, we can begin to tackle some of the complex ways in which language, roles, power and culture have contributed to our own sense of internalized oppression in any form.
Adding some "Dirt" to "Clean" energy: Applying clay nanocomposites in solar cells (2017)

Abstract not provided.
Computational Explorations of Mechanisms and Ligand-Directed Selectivities of Copper-Catalyzed Ullmann-Type Reactions (2010)

Computational investigations of ligand-directed selectivities in Ullmann-type coupling reactions of methanol and methylamine with iodobenzene by beta-diketone- and 1,10-phenanthroline-ligated Cu(I) complexes are reported. Density functional theory calculations using several functionals were performed on both the nucleophile formation and aryl halide activation steps of these reactions. The origin of ligand-directed selectivities in N- versus O-arylation reactions as described in a previous publication (J. Am. Chem. Soc. 2007, 129, 3490-3491) were studied and explained. The selectivities observed experimentally are derived not from initial Cu(I)(nucleophile) complex formation but from the subsequent steps involving aryl halide activation. The arylation may occur via single-electron transfer (SET) or iodine atom transfer (IAT), depending on the electron-donating abilities of the ligand and nucleophile. Mechanisms involving either oxidative addition/reductive elimination or sigma-bond metathesis are disfavored. SET mechanisms are favored in reactions promoted by the beta-diketone ligand; N-arylation is predicted to be favored in these cases, in agreement with experimental results. The phenanthroline ligand promotes O-arylation reactions via IAT mechanisms in preference to N-arylation reactions, which occur via SET mechanisms; this result is also in agreement with experimental results.
Storage and Retrieval of XML Data Using Relational Databases (2001)

The Extensible Markup Language (XML) is becoming the dominant standard for exchanging data over World Wide Web. Due to its flexibility, XML is rapidly emerging as the de facto standard for exchanging and querying documents on the Web to the next generation web applications including electronic commerce and intelligent web searching. XML documents can be stored and queried by using specialized semistructure repositories. While this is a viable approach to handle XML data, these specialized systems are yet premature since the semistructure data research itself is still young. Furthermore, it does not allow us to use the state-of-the-art relational database technologies available today that have been developed and tuned for last decades. Not only that, large volumes of data available today generally exist in relational database systems. Therefore, efficient storage and retrieval of native XML data and existing relational data seamlessly is becoming important. In fact, all major commercial relational vendors are working hard to support such capabilities and to build an infrastructure to enable them. However, they face the following three challenges: (1) how to represent XML data in relational model, (2) how to support XML query’s processing over XML data stored in relational databases, and (3) how to publish existing relational data to XML format. We will discuss current state of the art technologies for these challenges and present the future research issues. Surajit Chaudhuri is a senior researcher and manager of the DataManagement, Exploration and Mining Group at Microsoft Research. He has worked extensively in the area of self-tuning database technology, query processing, data warehousing and data mining on SQL systems. He has published many papers in leading database conferences and journals. His work on self-tuning database technology and data mining has been incorporated in the Microsoft SQL Server product. Surajit has been a member of program committees of leading database and data mining conferences. In 1999, he was the co-chair of the ACM International Conference on Knowledge Discovery and Data Mining and co-chair of the industrial track of the ACM SIGMOD conference. Surajit did his Ph.D. from Stanford University and B.Tech from Indian Institute of Technology (Kharagpur, India). Prior to joining Microsoft Research, he was a member of the research staff at Hewlett-Packard Laboratories (Palo Alto) from 1992-1995
A new minor histocompatibility locus linked to H-3. (1981)

B10, BALB.B, and A.BY shared an allele at a new locus not shared by B10.LP-H-3b. This locus is linked to the minor histocompatibility gene, H-3, in the 5th linkage group of chromosome 2 of the mouse. The product of the new gene fits the criteria of a minor histocompatibility antigen, since it induced as well as served as a target for cytotoxic lymphocytes (CTL) and its presence accelerated skin graft rejection when compared with that caused by H-3.1. F1 complementation of skin graft rejection and generation of CTL indicated that A.BY and BALB.B do not share H-3a with B10 as previously reported but possess the c allele of their congenic partners A and BALB/c. Thus, B10.LP-H-3b and B10 differ from one another by at least 2 minor histocompatibility loci. The specificity of CTL developed in B10. LP-H-3b and appropriate F1 hybrids indicate that the lytic activity of CTL specific for H-3.1 was restricted to target cells possessing H-2Kb antigens; this contrasted to the H-2Db-restricted activity of CTL specific for the product of the new gene.
HoloFlex (2016)

We present HoloFlex, a 3D flexible smartphone featuring a light-field display consisting of a high-resolution P-OLED display and an array of 16,640 microlenses. HoloFlex allows mobile users to interact with 3D images featuring natural visual cues such as motion parallax and stereoscopy without glasses or head tracking. Its flexibility allows the use of bend input for interacting with 3D objects along the z axis. Images are rendered into 12-pixel wide circular blocks-pinhole views of the 3D scene-which enable ~80 unique viewports at an effective resolution of 160 × 104. The microlens array distributes each pixel from the display in a direction that preserves the angular information of light rays in the 3D scene. We present a preliminary study evaluating the effect of bend input vs. a vertical touch screen slider on 3D docking performance. Results indicate that bend input significantly improves movement time in this task. We also present 3D applications including a 3D editor, a 3D Angry Birds game and a 3D teleconferencing system that utilize bend input.