gebhart/patrepeval huggingface dataset:
A hybridization of Mathematical Programming and search techniques for integrated operation and workforce planning (2007)

Decision-support tools are essential to assist planners when scheduling operations in complex systems. It is critical that real-world operational and workforce details be taken into account when constructing models of the system, so as to ensure the feasibility and implementability of the final solution. However, the level of detail can greatly impact the tractability of the model - for example, increased modeling complexity can decrease the performance of mathematical programming (MP) techniques. Furthermore, high levels of detail are often important for ensuring feasibility but may not dramatically impact system cost. This research is motivated by our efforts to develop decision-support tools that simultaneously create workforce and detailed operational plans. The focus of this paper is to solve the first phase of an integrated workforce and operation plan, that is, to determine the minimum amount of time workers are required to meet demand. In our initial experience, we were able to model the real-world problem with sufficient accuracy, but found that MP approaches to finding optimal solutions to this model were inefficient. In this paper, we describe how using MP to find feasible solutions, then embedding these feasibility problems in a search-based algorithm, allowed us to find high-quality solutions. We present the general model and algorithm and then an automotive supply chain example to illustrate this technique.
A flexible feedback framework for 5G massive MIMO systems (2017)

Massive MIMO systems are a key technology for next generation cellular networks. Albeit their numerous advantages, they present a dimensionality challenge when the number of users and the number of antenna ports increases, especially when the number of antennas grows increasingly large. In this paper, we propose a novel flexible codebook design framework that leverages the approximation of the covariance matrix with a Kronecker product model of three domain components: azimuth, vertical and uncorrelated dimensions. We derive the component matrices of the Kronecker product model, and we present simulation results to corroborate this approximation. The analysis in this paper lays the theoretical foundation for usage of a product codebook to reduce the complexity and the dimensionality of feedback in massive MIMO systems.
High-Performance Carbon Nanotube Fiber (2007)

With their impressive individual properties, carbon nanotubes should form high-performance fibers. We explored the roles of nanotube length and structure, fiber density, and nanotube orientation in achieving optimum mechanical properties. We found that carbon nanotube fiber, spun directly and continuously from gas phase as an aerogel, combines high strength and high stiffness (axial elastic modulus), with an energy to breakage (toughness) considerably greater than that of any commercial high-strength fiber. Different levels of carbon nanotube orientation, fiber density, and mechanical properties can be achieved by drawing the aerogel at various winding rates. The mechanical data obtained demonstrate the considerable potential of carbon nanotube assemblies in the quest for maximal mechanical performance. The statistical aspects of the mechanical data reveal the deleterious effect of defects and indicate strategies for future work.
Probing Differences in Gene Essentiality Between the Human and Animal Adapted Lineages of the Mycobacterium tuberculosis Complex Using TnSeq (2021)

Members of the <i>Mycobacterium tuberculosis</i> complex (MTBC) show distinct host adaptations, preferences and phenotypes despite being >99% identical at the nucleic acid level. Previous studies have explored gene expression changes between the members, however few studies have probed differences in gene essentiality. To better understand the functional impacts of the nucleic acid differences between <i>Mycobacterium bovis</i> and <i>Mycobacterium tuberculosis</i>, we used the Mycomar T7 phagemid delivery system to generate whole genome transposon libraries in laboratory strains of both species and compared the essentiality status of genes during growth under identical <i>in vitro</i> conditions. Libraries contained insertions in 54% of possible TA sites in <i>M. bovis</i> and 40% of those present in <i>M. tuberculosis</i>, achieving similar saturation levels to those previously reported for the MTBC. The distributions of essentiality across the functional categories were similar in both species. 527 genes were found to be essential in <i>M. bovis</i> whereas 477 genes were essential in <i>M. tuberculosis</i> and 370 essential genes were common in both species. CRISPRi was successfully utilised in both species to determine the impacts of silencing genes including <i>wag31</i>, a gene involved in peptidoglycan synthesis and <i>Rv2182c</i>/<i>Mb2204c</i>, a gene involved in glycerophospholipid metabolism. We observed species specific differences in the response to gene silencing, with the inhibition of expression of <i>Mb2204c</i> in <i>M. bovis</i> showing significantly less growth impact than silencing its orthologue (<i>Rv2182c</i>) in <i>M. tuberculosis</i>. Given that glycerophospholipid metabolism is a validated pathway for antimicrobials, our observations suggest that target vulnerability in the animal adapted lineages cannot be assumed to be the same as the human counterpart. This is of relevance for zoonotic tuberculosis as it implies that the development of antimicrobials targeting the human adapted lineage might not necessarily be effective against the animal adapted lineage. The generation of a transposon library and the first reported utilisation of CRISPRi in <i>M. bovis</i> will enable the use of these tools to further probe the genetic basis of survival under disease relevant conditions.
Reduced Mitochondrial Function in Human Huntington Disease Lymphoblasts is Not Due to Alterations in Cardiolipin Metabolism or Mitochondrial Supercomplex Assembly (2016)

Huntington's Disease (HD) is an autosomal dominant disease that occurs as a result of expansion of the trinucleotide repeat CAG (glutamine) on the HTT gene. HD patients exhibit various forms of mitochondrial dysfunction within neurons and peripheral tissues. Cardiolipin (Ptd2Gro) is a polyglycerophospholipid found exclusively in mitochondria and is important for maintaining mitochondrial function. We examined if altered Ptd2Gro metabolism was involved in the mitochondrial dysfunction associated with HD. Mitochondrial basal respiration, spare respiratory capacity, ATP coupling efficiency and rate of glycolysis were markedly diminished in Epstein-Barr virus transformed HD lymphoblasts compared to controls (CTRL). Mitochondrial supercomplex formation and Complex I activity within these supercomplexes did not vary between HD patients with different length of CAG repeats and appeared unaltered compared to CTRL. In contrast, in vitro Complex I enzyme activity in mitochondrial enriched samples was reduced in HD lymphoblasts compared to CTRL. The total cellular pool size of Ptd2Gro and its synthesis/remodeling from [(3)H]acetate/[(14)C]oleate were unaltered in HD lymphoblasts compared to CTRL. In addition, the molecular species of Ptd2Gro were essentially unaltered in HD lymphoblasts compared to CTRL. We conclude that compared to CTRL lymphoblasts, HD lymphoblasts display impaired mitochondrial basal respiration, spare respiratory capacity, ATP coupling efficiency and rate of glycolysis with any pathological CAG repeat length, but this is not due to alterations in Ptd2Gro metabolism. We suggest that HD patient lymphoblasts may be a useful model to study defective energy metabolism that does not involve alterations in Ptd2Gro metabolism.
Polyphenol-Rich Beverages and Mental Health Outcomes (2023)

Emerging evidence suggests that diets rich in plant-based foods and beverages may exert plausible effects on human health tackling the risk of chronic diseases. Although the data are promising for numerous outcomes, including cardiovascular diseases, the data on mental health are limited. The aim of this study was to investigate the association between individual polyphenol-rich beverages intake and mental health outcomes, such as perceived stress, depressive symptoms, and sleep quality, among adult individuals living in the Mediterranean area. The demographic and dietary characteristics of a sample of 1572 adults living in southern Italy were analysed. Multivariate logistic regression analyses, controlling for confounding factors, were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) of the association between individual polyphenol-rich and alcoholic beverages containing polyphenols and mental health outcomes. The multivariate model adjusted for background covariates and the Mediterranean diet showed that individuals with a moderate intake (up to 1 cup/glass per day) of coffee and tea were less likely to have high perceived stress (OR = 0.61, 95% CI: 0.45-0.84) and depressive symptoms (OR = 0.56, 95% CI: 0.39-0.80), respectively. Furthermore, regular coffee and moderate/regular red wine drinkers were less likely to have depressive symptoms (OR = 0.72, 95% CI: 0.54-0.95 and OR = 0.74, 95% CI: 0.54-0.99, respectively). No significant associations were retrieved for the intake of polyphenol-rich and alcoholic beverages and sleep quality. In conclusion, the results of the present study suggest that polyphenol-rich beverages may be associated with mental health, in terms of depressive symptoms and perceived stress. Nonetheless, further research exploring how the polyphenol-rich beverages impact brain health and what the optimal patterns of consumption are for different populations are warranted.
Feasibility and physics potential of detecting 8B solar neutrinos at JUNO * (2021)

Abstract The Jiangmen Underground Neutrino Observatory (JUNO) features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector. Some of JUNO's features make it an excellent location for B solar neutrino measurements, such as its low-energy threshold, high energy resolution compared with water Cherenkov detectors, and much larger target mass compared with previous liquid scintillator detectors. In this paper, we present a comprehensive assessment of JUNO's potential for detecting B solar neutrinos via the neutrino-electron elastic scattering process. A reduced 2 MeV threshold for the recoil electron energy is found to be achievable, assuming that the intrinsic radioactive background U and Th in the liquid scintillator can be controlled to 10 g/g. With ten years of data acquisition, approximately 60,000 signal and 30,000 background events are expected. This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter, which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework. If eV , JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3 (2 ) level by measuring the non-zero signal rate variation with respect to the solar zenith angle. Moreover, JUNO can simultaneously measure using B solar neutrinos to a precision of 20% or better, depending on the central value, and to sub-percent precision using reactor antineutrinos. A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of reported by solar neutrino experiments and the KamLAND experiment.
Is Peripheral Neuropathy Associated With Retinopathy and Albuminuria in Individuals With Impaired Glucose Metabolism? (2006)

Individuals with impaired glucoses tolerance (IGT) or impaired fasting glucose (IFG) are at substantially increased risk of developing diabetes and cardiovascular disease (1). The extent to which individuals with IGT/IFG are also at risk of microvascular complications, such as neuropathy, retinopathy, and nephropathy, has not been as well defined. Some (2,3), but not all (4–7), studies have shown that microvascular complications are more common in individuals with IGT/IFG than those with normal glucose metabolism.

Peripheral neuropathy, a common microvascular complication of diabetes (8), is often associated with concomitant retinopathy (9) and albuminuria (9,10). Whether peripheral neuropathy is also associated with retinopathy and albuminuria in people with IGT/IFG is unclear and is examined in the current study.

The Australian, Diabetes, Obesity, and Lifestyle Study (AusDiab) is a population-based survey of Australian adults aged ≥25 years (11). Glucose tolerance status was determined by a 75-g oral glucose tolerance test (12). The prevalence of diabetes in the AusDiab was 7.4%, while 16.4% had IGT or IFG (13). All participants with diabetes, IGT, IFG, and a random sample of normal control subjects were invited for complications testing (6). This analysis is based on the 1,154 individuals with IGT or IFG who attended the complications screening.

Neuropathy was classified by 1 ) the modified neuropathy symptom score (NSS), 2 ) the modified neuropathy disability score (NDS), 3 ) the pressure perception score (PPS), and 4 ) a postural systolic blood pressure drop score of ≥20 mmHg. The NSS measured …
Optimized design of a back-to-back rotor-side converter for doubly fed induction generator equipped Wind turbines (2009)

The paper approaches the analysis of the performances of doubly-fed induction generators for grid-connected wind turbines by means of algebraic analytical relationships given by the mathematical model of the machine. These relationships are used to carry out a control strategy which aims to maximize the global efficiency of the generation system. Some considerations about the sizing of the rotor converter are also reported. The control strategy has been verified by means of numerical simulations.
Madrid Quantum Network (2021)

The rapid technological advances in the field of quantum communications and the arrival of quantum computers, with a sufficient number of qubits to break the most used encryption algorithms used to date will change the Internet paradigm, as we know it today. Research centers, universities, industries and governments are working hard on the development of more scalable and efficient quantum communications networks, as well as the standardization of protocols, processes and interfaces needed for its industrialization. Many are the definitions of what will be the quantum Internet of the future (its architecture and components), but we offer a more relaxed definition of this concept, so that it is already possible to have a primitive QI with the technology available today, but without all the functionalities and components that will have in the future. As an example, the Madrid Quantum Network meets the requirements of this basic QI, proving to be a first step towards more complex architectures and functionalities. In addition, this concept has direct application as an intranet in restricted military environments, where high levels of security are required and whose extension is limited to metropolitan areas.
University/industry cooperative teaching laboratory for undergraduate education (2002)

An undergraduate optics laboratory sponsored by the National Science Foundation of the United States was established to foster a link between local industry and academia. A series of innovative experiments was developed utilizing high-speed data acquisition equipment and signal processing software to demonstrate the fundamentals of diffraction, fiber optics, and physical optics principles. The experiments were performed in two complementary settings. The university experiments concentrated on basic optical principles and experimental techniques. A parallel industrial component was provided by local industry. Students were invited to industrial research laboratories to work on real-life optical problems of current interest. The students were able to see the relevance between fundamental optical principles and real industrial problems, use state-of-the-art equipment, and experience working in an industrial laboratory. Feedback was also solicited from industry management regarding improvements to academic training of students for the work force.
A Study of Ligamentous Growth (1988)

Scant data are available on the growth of ligament. This study answers basic questions concerning mechanisms of ligament growth and determines the location of longitudinal ligament growth. Growing rabbits had metal marking sutures implanted, at measured intervals, along the length of their medial collateral ligament. Separate metal markers were inserted in the epiphysis and metaphysis of the femur and tibia. Changes in marker intervals were measured radiographically after growth. Measurements revealed that growth occurred throughout the length of the ligament, with somewhat greater growth occurring in the distal segment. Total ligament growth was much less than that occurring at the tibial physis (which the ligament crosses). The magnitude of total ligament growth was proportional to the enlargement of the joint itself, as measured by changes in the distance between epiphyseal markers. The most distal suture inserted in the ligament became incorporated in bone and moved rapidly away from the ligament insertion. This rapid displacement of the distal suture was not responsible for enlargement of the ligament itself, but rather a phenomenon of the maintenance of the position of the ligament insertion on the proximal metaphysis, as the epiphysis grows away from the original site of ligament insertion.
Alkali metal salts-assisted coupling reaction between fluorinated benzyl electrophiles and alkenylboronic acids (2022)

Transition metal-free ion pair assisted nucleophilic substitution reactions.
Low-Profile, Switched-Beam Diversity Antennas Using High-Impedance Ground Planes (2000)

We explore high-impedance surfaces for use in low-profile, switched-beam diversity antennas for mobile communications. High-impedance surfaces provide two important advantages for low-profile antennas: (1) They suppress the propagation of surface currents. (2) Image currents appear inphase, rather than our-of-phase as on an ordinary metal ground plane. This results in improved radiation properties by partially isolating the antenna from the nearby electromagnetic environment. Furthermore, radiating elements can lie directly adjacent to the ground plane without being shorted out. A low-profile, four-sector diveristy antenna on a high-impedance surface is described, and radiation performance is characteriazed.
Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus (1990)

Cystatin C is a human cysteine proteinase inhibitor present in extracellular fluids. Cystatin C and a tripeptide derivative (Z-LVG-CHN2) that mimics its proteinase-binding center, were tested for possible antiviral activity against herpes simplex virus type 1 (HSV) and poliovirus type 1. Both recombinant cystatin C and Z-LVG-CHN2 displayed strong inhibitory effects on HSV replication, whereas no significant effect on poliovirus replication was seen. The molar concentration of cystatin C that gave total inhibition of HSV replication was lower than that of either Z-LVG-CHN2 or of acyclovir, the drug currently most used against HSV infections. These results suggest that cysteine proteinase inhibitors might play a physiological role as inhibitors of viral replication and that such proteinase inhibitors, or peptide derivatives that mimic their proteinase-binding centers, might be used as antiviral agents.
Hydrogen Evolution from Glucose with the Combination of Glucose Dehydrogenase and Hydrogenase from A. eutrophus H16 (1999)

Abstract Hydrogen production system from glucose consisting of glucose dehydrogenase from Bacillus sp. and hydrogenase from Alcaligenes eutrophus H16 was established. When the solution containing glucose, glucose dehydrogenase, NAD, and hydrogenase was incubated at 30 °C, hydrogen evolution was observed.
HYPOTHERMIA INCREASES INTRINSIC PLATELET REACTIVITY IN VITRO (1995)

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287
Ultrasound-targeted Bubble Liposome Destruction Enhances AG73-mediated Gene Transfer by Improvement of Intracellular Trafficking (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Daiki Omata, Yoichi Negishi, Yoko Endo‐Takahashi, Ryo Suzuki, Kazuo Maruyama, Motoyoshi Nomizu, Yukihiko Aramaki; Ultrasound‐targeted Bubble Liposome Destruction Enhances AG73‐mediated Gene Transfer by Improvement of Intracellular Trafficking. AIP Conf. Proc. 12 September 2011; 1359 (1): 326–329. https://doi.org/10.1063/1.3607927 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Does the BOLD signal reflect input or output of a cortical area? - Laminar patterns of Gamma-band activities in Macaque visual cortex (2011)

fMRI has been widely used for basic and clinical studies. While cortical neural activity varies with changes of cortical depth of less than 0.2 mm, the BOLD signal averages over voxels of 1–3 mm on a side. This leads to an open question: does BOLD pool brain activity evenly from all layers in a cortical region or it is dominated by signals from some particular layers? We tried to answer this question by measuring the laminar patterns of Gamma-band activity in Macaque primary visual cortex (V1). The rationale was: if gamma-band activity in the local field potential (LFP) is related to BOLD, as several studies (Logothetis, 2001 & Goense and Logothetis, 2008) have claimed, the laminar pattern of gamma activity should indicate which cortical layers contribute to the BOLD signal. We measured the LFP in V1 visually driven by a large patch (2–3 deg in radius) of sinusoidal grating drifting in different directions (0 to 360 deg, 30 deg intervals) at high contrast (99%) as well as at zero contrast (blank screen). With track reconstruction, we identified the cortical depth for each recording site, and then studied the visually-driven activity in the gamma-band as a function of cortical depth. From 315 recording sites in 6 anaesthetized monkeys, we found gamma activity was strongest in layer 4B and layer 2/3. Gamma-power was generally weaker in the deep layers with a sharp drop in gamma power at the border of layer 4Cα and 4Cβ: layers 4Cβ, 5 and 6 showed weaker gamma power. Our results suggest that 1) V1's BOLD signal will be dominated by gamma-power in layers 2/3 and 4B; 2) the BOLD signal reflects activity in the output instead of the input layers; 3) the BOLD signal is most influenced by activity in cortical layers with strong recurrent connections.
Quantifying and Comparing Surrogate Fold Motions in Thick Sheet Materials (2015)

Origami-based design is increasing in popularity as its benefits and advantages become better understood and explored. Surrogate folds are a means of achieving fold-like behavior, offering solutions for origami-based products in new materials. A surrogate fold is a localized reduction in stiffness in a given direction allowing the material to function like a fold. A family of surrogate folds is reviewed and the respective behaviors of the folds discussed. For a given fold configuration, the material thickness is varied to yield different sizes of surrogate folds. Constraint assumptions drive the design, and the resultant configurations are compared for bending motions. Finite element and analytical models for the folds are also compared. Prototypes are made from different materials. This work creates a base for creating design guidelines for using surrogate folds in thick sheet materials.