gebhart/patrepeval huggingface dataset:
TOPICAL BROMFENAC AS AN ADJUNCTIVE TREATMENT WITH INTRAVITREAL RANIBIZUMAB FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION (2012)

Topical bromfenac might reduce the frequency of ranibizumab over 6 months in eyes with relatively small age-related macular degeneration lesions.
Novel GIP/GLP-1/Glucagon Receptor Agonist LY3437943: A First in Human Dose Study in Healthy Subjects (2022)

Background The novel compound LY3437943 has potent agonist activity on GIP, GLP-1 and glucagon receptors. This randomized, double-blind, placebo-controlled, Phase 1, first in human study assessed safety and tolerability of single-ascending doses of LY3437943.
The Effect of Spinopelvic Motion on Implant Positioning and Hip Stability Using the Functional Safe Zone of THR (2020)

Accurate and precise component positioning in total hip arthroplasty is a ubiquitous goal amongst hip surgeons and an important topic of research. Early studies defined a “safe zone” for placement of the acetabular cup, and divergence from the defined safe zone was shown to predispose patients to dislocation [1]. However, ideas regarding the position of the acetabular cup have continued to evolve beyond the initial description by Lewinnek in 1978 [1]. Murray et al. [2], in 1993, defined anatomic, operative, and radiographic parameters for inclination and anteversion. DiGioa et al. expanded upon this work by describing functional cup position, rather than just anatomical inclination and anteversion, as being the angles of the acetabulum that correlated to the axis of the body, using lateral radiographic measurements of the spine, pelvis, and hip [3]. This expanded definition was the first to consider spinal parameters as part of a functional spine–pelvis–hip relationship. Lazennec et al. [4], in France, used a new imaging modality (EOS, Biospace Med, Paris, France) to clearly demonstrate the interrelationship of spinal mobility to acetabular position during postural change of sitting to standing (Fig. 12.1). This research increased our understanding that spine–pelvis–hip motion is synchronized for the purpose of allowing the normal hip to move freely through its arc of motion without the greater trochanter impinging on the pelvis, or the lesser trochanter on the ischium. As hip surgeons learned more about the anatomy of this spine–pelvis–hip relationship, research shifted to studying the effect of this relationship on outcomes following total hip arthroplasty. The cumulative effect of that work has been to redefine the safe zone for acetabular component positioning (functional safe zone) and the influence of sagittal hip motion by taking into account spinopelvic motion. This chapter will focus on the evolving definition of an acetabular safe zone in the context of the spine–pelvis–hip construct, as well as how to personalize and optimize component positioning based on patient-specific spinopelvic parameters.
Unique neoantigens expressed by melanomas and common epithelial cancers presented by multiple HLA alleles can be efficiently identified utilizing peptide prediction algorithms (2015)

Meeting abstracts Previous observations indicate that complete regression of metastatic melanoma can be mediated by CD8 lymphocytes that predominantly recognize unique tumor specific mutations predicted in-silico to bind in context of HLA-A*02:01 [[1][1]]. The goal of this project was to expand
Reconstitution of light-harvesting complexes and photosystem II cores into galactolipid and phospholipid liposomes. (1985)

Chlorophyll a/b light-harvesting complexes (chl a/b LHC) and photosystem II (PSII) cores were isolated from an octyl glucoside-containing sucrose gradient after solubilization of barley thylakoid membranes with Triton X-100 and octyl glucoside. No cation precipitation step was necessary to collect the chl a/b LHC. PAGE under mildly denaturing and fully denaturing conditions showed that the chl a/b LHC fraction contained chlorophyll-protein complexes CP27, CP29, and CP64. The PSII core material contained CP43 and CP47, and little contamination by other nonpigmented polypeptides. Freeze-fracture electron microscopy of the chl a/b LHC after reconstitution into digalactosyldiglyceride (DG) or phosphatidylcholine (PC) vesicles showed that the protein particles (approximately 7.5 +/- 1.6 nm) were approximately 99 and 90% randomly dispersed, respectively, in the liposomes. Addition of Mg++ produced particle aggregation and membrane adhesion in chl a/b LHC-DG liposomes in a manner analogous to that described for LHC-PC liposomes. Reconstitution of PSII cores into DG vesicles also produced proteoliposomes with randomly dispersed particles (approximately 7.5 +/- 1.6 nm). In contrast, PSII-PC mixtures formed convoluted networks of tubular membranes that exhibited very few fracture faces. Most of the protein particles (approximately 7.0 +/- 1.5 nm) were seen trapped between, rather than embedded in, the membranes. The interaction between the zwitterionic head group of the phosphatidyl choline and the negatively charged PSII core may be responsible for the unusual membrane structures observed.
Disruption of hedgehog signalling in ApoE − /− mice reduces plasma lipid levels, but increases atherosclerosis due to enhanced lipid uptake by macrophages (2007)

Embryonic pathways are often re-expressed in adult pathology. Here we investigated the role of the morphogen hedgehog (hh), which we found to be re-expressed in atherosclerotic plaques. Male ApoE - /- mice were treated for 12 weeks with an anti-hh antibody (5E1) or a control IgG (1E6) starting at the age of 6 or 18 weeks. Inhibition of hh signalling induced a significant increase in total plaque area in the aortic arch, a result of an increase (54% and 36%, respectively) in the area of advanced plaques (atheromata). In mice treated with anti-hh, plaques contained large (18-35% > ctrl), lipid-filled, sometimes multinucleated macrophage foam cells. Plasma cholesterol levels decreased after anti-hh treatment. In bone marrow-derived macrophages, foam cell formation was enhanced after inhibition of hh signalling. Anti-hh treatment caused a 54-75% increase in early oxLDL uptake (10-240 min), which was scavenger receptor-mediated. After 3-24 h of oxLDL incubation, intense Oil red O staining as well as increased amounts of cholesterol esters were present in these macrophages after anti-hh treatment. Activation of the HH-signalling cascade by recombinant Shh induced a decrease in oxLDL uptake. Here we show that the hh-signalling pathway is one of the morphogenic pathways that regulate plasma lipid levels and atherosclerosis development and progression.
Safety switch optimization enhances antibody-mediated elimination of CAR T cells (2022)

Activation of a conditional safety switch has the potential to reverse serious toxicities arising from the administration of engineered cellular therapies, including chimeric antigen receptor (CAR) T cells. The functionally inert, non-immunogenic cell surface marker derived from human epidermal growth factor receptor (EGFRt) is a promising safety switch that has been used in multiple clinical constructs and can be targeted by cetuximab, a clinically available monoclonal antibody. However, this approach requires high and persistent cell surface expression of EGFRt to ensure that antibody-mediated depletion of engineered cells is rapid and complete. Here we show that incorporating a short juxtamembrane sequence into the EGFRt polypeptide enhances its expression on the surface of T cells and their susceptibility to antibody-dependent cellular cytotoxicity (ADCC). Incorporating this optimized variant (EGFRopt) into bicistronic and tricistronic CAR designs results in more rapid <i>in vivo</i> elimination of CAR T cells and robust termination of their effector activity compared to EGFRt. These studies establish EGFRopt as a superior safety switch for the development of next-generation cell-based therapeutics.
Preparation and Characterization of High Molecular Weight Low Bandgap Polymers Based on Poly(2,7-carbazole)s for Organic Solar Cells (2012)

We report the PCDTBT {Poly[N-9'-heptadecanyl-2,7-carbazole-alt-5,5-(4',7'-di-2-thienyl-2',1',3'-benzothiadiazole)]}, an alternating copolymer of 2,7-carbazole and dithienyl-2,1,3-benzothiazole, has high molecular weight and narrow molecular weight distribution. Our PCDTBT can be successfully prepared as good yield by using tetrakis(triphenylphosphine)palladium [Pd(PPh3)4] catalyst instead of Pd2dba3/P(o-Tol)3 catalyst. From the UV/Vis absorption spectroscopy, we can observe that absorption bands of PCDTBT are bathochromically shifted by increasing the molecular weight, that is to say, our high molecular weight PCDTBT can absorb much longer wavelength light compare to low molecular weight PCDTBT. The best performance can be obtained from device based on the mixture of PCDTBT (polymer-30) and PC70BM {[6,6]-phenyl C71-butyric acid methyl ester} (1:4) as an active layer, which shows 4.50% of PCE with 10.1 mA/cm2 of short-circuit current density (J(SC)), 0.85 V of open-circuit voltage (V(OC)), and 52.3% of fill factor which is very similar with Leclerc's published result.
Dynamic aperture optical arrays based on polymeric MEMS actuators for large scale coding elements with application in visible to MWIR (2007)

Extension of coded apertures to the MWIR introduces the effects of diffraction and other distortions not observed in shorter wavelength systems. A new approach is being developed under the DARPA/SPO funded LACOSTE (Large Area Coverage Optical search-while Track and Engage) program, that addresses the effects of diffraction while gaining the benefits of coded apertures, thus providing flexibility to vary resolution, possess sufficient light gathering power, and achieve a wide field of view (WFOV). The photonic MEMS "eyelid" array technology is currently being instantiated in this DARPA Surveillance program study as the "heart", mediating the flow of the incoming signal. However, speed, lifetime, packaging and scalability are critical factors for the MEMS "eyelid" technology which will determine system efficacy as well as military and commercial usefulness. The electronic eyelid array is the fundamental addressable unit for adaptive code generation and will allow the system to multiplex in time for increased resolution. The binary code which determines whether a 500&mu;m eyelid is open or closed is referred to as the "eyelid code." Groups of eyelids can work together as a "super aperture" by virtue of a "macro-code." A macro code becomes relevant to describe how dispersed eyelids across the 0.19m x 0.19m aperture will function together. Dynamic aperture arrays were fabricated on both quartz and sapphire substrates for operation in the visible to MWIR. Both 8x8 and 40x40 element arrays were designed, fabricated, and tested with macro-codes consisting of 4, 8, and 16 unique combinations. The die were packaged and tested in ambient for robust eyelid operations. The point spread function was also measured in an optical setup with the eyelid arrays located in the aperture plane.
Desferrithiocin is a more potent antineoplastic agent than desferrioxamine (2002)

Desferrithiocin (DFT) is an orally effective Fe chelator, with a similar high affinity and selectivity for Fe to desferrioxamine (DFO), which has been shown clinically to possess antineoplastic activity. In this study, DFT was assessed for antineoplastic potential in hepatocellular carcinoma cell lines (HCC). This was done as there are few treatments for this aggressive neoplasm. The effects of DFT on cell proliferation, cell cycle progression, Fe uptake and toxicity were examined. To establish whether DFT was selective for cancer cells a comparison was made with normal (non-proliferating) hepatocytes and non-tumorigenic (proliferating) fibroblasts (SWISS-3T3). DFT was a potent inhibitor of HCC proliferation (IC(50) approximately 40 microM). DFO also inhibited HCC proliferation under the same conditions, but was much less active (IC(50)=110 - 210 microM). When saturated with Fe, the activity of DFT, like DFO, was greatly diminished, suggesting it may act by depriving the cells of Fe or inactivating essential Fe pool(s). Indeed DFT rapidly decreased Fe uptake from Tf-(59)Fe by hepatoma cells and also by normal hepatocytes. However, DFT (and DFO) had much less effect on cell survival in hepatocytes and fibroblasts than in hepatoma cells. DFT may, like DFO, inhibit the cell cycle in the S phase of DNA synthesis. Both chelators showed low toxicity. These results indicate that DFT has potent antineoplastic activity in HCC. Further investigation into the DFT class of Fe chelators seems warranted, particularly in view of its high activity in relation to DFO, a chelator which is already in clinical trial for neuroblastoma.
Resliced image space construction for coronary artery collagen fibers (2017)

Collagen fibers play an important role in the biomechanics of the blood vessel wall. The objective of this study was to determine the 3D microstructure of collagen fibers in the media and adventitia of coronary arteries. We present a novel optimal angle consistence algorithm to reform image slices in the visualization and analysis of 3D collagen images. 3D geometry was reconstructed from resliced image space where the 3D skeleton was extracted as the primary feature for accurate reconstruction of geometrical parameters. Collagen fibers (range 80-200) were reconstructed from the porcine coronary artery wall for the measurement of various morphological parameters. Collagen waviness and diameters were 1.37 ± 0.19 and 2.61 ± 0.89 μm, respectively. The biaxial distributions of orientation had two different peaks at 110.7 ± 25.2° and 18.4 ± 19.3°. Results for width, waviness, and orientation were found to be in good agreement with manual measurements. In addition to accurately measuring 2D features more efficiently than the manual approach, the present method produced 3D features that could not be measured in the 2D manual approach. These additional parameters included the tilt angle (5.10 ± 2.95°) and cross-sectional area (CSA; 5.98 ± 3.79 μm2) of collagen fibers. These 3D collagen reconstructions provide accurate and reliable microstructure for biomechanical modeling of vessel wall mechanics.
Nonlinear aspects of acoustic radiation force in biomedical applications (2015)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Lev Ostrovsky, Sergey Tsyuryupa, Armen Sarvazyan; Nonlinear aspects of acoustic radiation force in biomedical applications. AIP Conf. Proc. 28 October 2015; 1685 (1): 040006. https://doi.org/10.1063/1.4934401 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Fastening and Joining of Composite Materials (2012)

This paper presents some of the most recent advances in fastening and joining research on composite joints, which are often viewed as the weakest links that can significantly affect the safety and reliability of many mechanical and structural systems. A system approach is outlined for fastening and joining issues, which includes the effect of six groups of variables; namely, the joint, the joining element, tool used, process control, in-service loads, and the environmental variables. Challenging bolting issues are discussed as they apply to composite joints that are subjected to complex mechanical, thermo-mechanical, and environmental loading. This includes theoretical, FEA, and experimental models for investigating the effect of bolt holes, failure modes, vibration and impact-induced loosening of preloaded threaded fasteners, loss of clamp load due to mismatched thermal effects, and elastic interaction. Investigated joining variables in layered joints include normal and interfacial stresses, properties and thickness of the adhesive layers, additives, and damage modeling. Results from theoretical and experimental models are presented.
Amplified C lambda and c-abl genes are on the same marker chromosome in K562 leukemia cells. (1983)

The human leukemia cell line K562, derived from a patient with Philadelphia chromosome-positive chronic myelogenous leukemia, contains amplified c-abl oncogenes and unrearranged C lambda genes. Using in situ hybridization techniques, we have determined that the amplified c-abl and C lambda DNA sequences of K562 cells are both located on the same abnormal acrocentric marker chromosome, which may represent an altered Philadelphia chromosome.
Emerging Membrane Technologies for Water and Energy Sustainability: Future Prospects, Constraints and Challenges (2018)

The increasing demand for global energy consumption expedites major opportunities for the innovation of green energy technologies. Addressing the issue of sustainable energy is highly crucial for societies in order to maintain secure and balanced future progress in the economy and ecologically. Recently, there has been a growing interest in the development of improved and efficient sustainable energy technologies that are capable of reducing the global environmental footprint. The growing knowledge of hybrid techniques contributes to a decrease in the use of environmental resources while generating energy. However, various factors including the availability of natural resources, and different economic policies restrict the development of sustainable energies. Water and energy are the two major aspects for progressing towards a sustainable future. Recently, membrane-based technologies have begun to play an essential role in the advancement of sustainable energy and water demands. In this review article, the opportunities for membrane technologies dealing with water and energy sustainability have been analyzed.
High capacity and access rate, data storage using laser communications (2021)

The amount of data in the world is expanding exponentially. About 90% of the world’s data has been created in the last two years, and almost 5% percent of the world’s power is used for data storage and computing. Lyteloop has an approach to data storage that uses optical communications to store data in motion between objects. Since the speed of light is fast, one needs very high data rates and very long paths to store large amounts of data. Data storage of petabytes, and even exabytes, is reasonable with this approach, in a format more compact than traditional data storage methods. LyteLoop has demonstrated an operating system using fiber, and currently has a system operating using free space. The fiber system stores >1 Gbyte, using 2000 km of fiber, and allows us to develop data center-like writing and retrieval experiences. Multiple patents have been filed with some granted. One of the patented concepts is called angle multiplexing, a method of dramatically increasing path length over a free-space path among multiple optical apertures. This has been demonstrated in free space using two different approaches. LyteLoop can store data in fiber, and in free space, either in a vacuum or in space.
N. gonorrhoeae: The varying mechanism of pathogenesis in males and females (2004)

Neisseria gonorrhoeae, the gonococcus, is the causative agent of gonorrhea, one of the oldest human diseases on record. Biblical references to gonorrhea in Leviticus (15:1–15:19) showed that the infectious nature of the disease was recognized even at that time. Probably, the best description of gonorrhea in a man in the preantibiotic era can be found in the writings of Boswell, who described in detail each of his 19 episodes of infection (Ober, 1970). These descriptions also allude to the asymptomatic nature of the disease in women, as many of the contacts from whom he acquired the infection were without symptoms of disease. Today, it is estimated that greater than 1 million cases of N. gonorrhoeae infection occur in the United States, and 60 million cases are reported annually worldwide. Hence, N. gonorrhoeae infection remains prevalent in the general population, despite the fact that antibiotic therapy is readily available. The high incidence of this disease remains a major concern in lower socioeconomic groups in the United States; however, the highest incidence of infection and of complications resulting from infection occur in developing countries. In underdeveloped nations it has been shown that patients with gonorrhea are at much higher risk for contracting human immunodeficiency virus (HIV). It is proposed that this increased susceptibility to HIV infection results from the inflammatory response generated by infecting gonococci with the subsequent disruption and shedding of the mucosal epithelium.
A Study of Correlation between Anti-peroxidative Potential of Quercetin and Ascorbic Acid with Malondialdehyde by RP-HPLC (2017)

Background: Lipid peroxidation induced by drug can be considered as drug induced toxicity. The concept of antioxidant co-therapy may be the way of future formulation design with an aim of reducing drug induced toxicity. Keywords: Free radical, antioxidants, anti cancer drug, lipid peroxidation, malondialdehyde, reverse phase HPLC.
A Scalable and License Free 5G Internet of Radio Light Architecture for Services in Homes & Businesses (2018)

In this paper we present a 5G Internet Radio-Light (IoRL) architecture for homes that can be readily deployed because it utilizes unlicensed visible light and millimeter wave part of the spectrum, which does not require Mobile Network Operator (MNO) permission to deploy and which is used to provide inhabitants of houses with accurate location, interaction, access to Internet and Cloud based services such as high resolution video on a Tablet PC. The paper describes the home use cases and the IoRL architecture.
Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using equilibrium competing inert hydroxymethylene diphosphonate (2021)

Abstract Bisphosphonate-related osteonecrosis of the jaw (BRONJ) presents as a morbid jawbone lesion in patients exposed to a nitrogen-containing bisphosphonate (N-BP). Although it is rare, BRONJ has caused apprehension among patients and healthcare providers and decreased acceptance of this anti-resorptive drug class to treat osteoporosis and metastatic osteolysis. We report here a novel method to elucidate the pathological mechanism of BRONJ by the selective removal of legacy N-BP from the jawbone using an intra-oral application of hydroxymethylene diphosphonate (HMDP) formulated in deformable nanoscale vesicles (DNV). After maxillary tooth extraction, zoledronate-treated mice developed delayed gingival wound closure, delayed tooth extraction socket healing and increased jawbone osteonecrosis consistent with human BRONJ lesion. Single cell RNA sequencing of mouse gingival cells revealed oral barrier immune dysregulation and unresolved pro-inflammatory reaction. HMDP-DNV topical applications to nascent mouse BRONJ lesions resulted in accelerated gingival wound closure and bone socket healing as well as attenuation of osteonecrosis development. The gingival single cell RNA sequencing demonstrated resolution of chronic inflammation by increased anti-inflammatory signature gene expression of lymphocytes and myeloid-derived suppressor cells. This study suggests that BRONJ pathology was predominantly induced by the oral N-BP and demonstrates the potential of HMDP-DNV as an effective BRONJ therapy. Brief Summary The targeted removal of legacy bisphosphonate from the jawbone by competitive equilibrium therapy elucidated the pathological mechanism of aberrant oral barrier immunity and bisphosphonate-related osteonecrosis of the jaw (BRONJ)