gebhart/patrepeval huggingface dataset:
Correlation of Structure and Molecular Weight Distributions during the Formation of Poly(methylphenylsilylene) by the Wurtz Reductive-Coupling Reaction (1998)

Variations of yields and molecular weight parameters of poly(methylphenylsilylene) formed through sodium-mediated Wurtz-type reductive coupling of dichloromethylphenylsilane in refluxing toluene are described. The intermediate molecular weight fractions within the polymodal distributions that result from such syntheses are shown to correlate well with the length of all-trans sequences within the polymer as revealed through the near-ultraviolet spectra of the fractionated polymers. The origins of the polymodal distributions are explained as being the consequence of a competition between termination through a backbiting reaction and a continued growth reaction whenever additions in gauche conformation arise. The likelihoods of such additions are reasoned to increase with the lengths of the all-trans sequences that arise from the preceding additions, and the termination reaction is rationalized as having a maximum probability when the polymer consists of only one such sequence. The reasoning is shown to correlate with the polydispersities of the intermediate and high molecular weight fractions within the overall molecular weight distribution of the polymer. Reasoning from this explanation of the mechanism of the polymerization, it is shown that it is possible to obtain high molecular weight, monomodal poly(methylphenylsilylene) in high yield from syntheses conducted in refluxing tetrahydrofuran.
Prognostic Implication of Right Ventricular Involvement in Peripartum Cardiomyopathy: A Cardiovascular Magnetic Resonance Study (2015)

Besides LV systolic dysfunction, RV dysfunction and dilatation are observed in about one third of PPCM patients at the time of diagnosis. RV dysfunction is associated with unfavourable outcome. A distinct pattern of LV wall motion abnormalities and myocardial scar is evident in most PPCM patients. The present study may help to establish a set of CMR criteria suitable for diagnosis in patients with suspected PPCM and may add further knowledge to the pathology of the disease.
An efficient switching threshold-based scheduling protocol for multiuser cognitive AF relay networks (2016)

The multiuser switched diversity (MUSwiD) selection scheme is useful in reducing the required amount of channel estimations and system complexity in wireless networks. In this paper, we propose and evaluate the performance of cognitive amplify-and-forward (AF) MUSwiD relay networks where a cognitive user is selected among a set of users for data reception. The selection process is performed such that the end-to-end (e2e) signal-to-noise ratio (SNR) of the selected user satisfies a predetermined switching threshold. An upper bound on the e2e SNR of a user is used in deriving closed-form approximations for the outage probability and average symbol error probability (ASEP) of the studied system. To get more insights about the system performance, the behavior is studied in the high SNR regime. The derived analytical and asymptotic expressions are verified by Monte-Carlo simulations. Main results illustrate that the diversity order of the studied cognitive AF multiuser switched diversity relaying network is the same as its non cognitive counterpart. Also, findings show that the asymptotic results tightly converge to the derived bounds and the analytical bounds are indeed very tight, validating the accuracy of our methodology. Finally, results show the effectiveness of the proposed MUSwiD scheduling scheme in reducing the channel estimation load compared to the opportunistic scheduling where the best user is always assigned the system resources.
High-speed serial link challenges using multi-level signaling (2015)

The paper discusses challenges of high-speed serial links using multi-level signaling and gives comparison of the performance of the various channels with different lossy materials and equalization options. Advantages and problems of multi-level signaling are shown based on the test results.
New Manuscript Type (2011)

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTNew Manuscript TypeStéphane Caron and Chris SenanayakeCite this: Org. Process Res. Dev. 2011, 15, 4, 757Publication Date (Web):May 23, 2011Publication History Published online23 May 2011Published inissue 15 July 2011https://pubs.acs.org/doi/10.1021/op200044qhttps://doi.org/10.1021/op200044qeditorialACS PublicationsCopyright © 2011 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1565Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (609 KB) Get e-AlertscloseSUBJECTS:Agrochemicals,Heterocyclic compounds,Organic reactions,Physical and chemical processes,Process chemistry Get e-Alerts
Role of Polymorphous Metastability in Crystal Formation Kinetics of 2,3,6,7,10,11-Hexa(4‘-Octyloxybenzoyloxy)-Triphenylene Discotic Molecules (2003)

Phase transition behaviors of a discotic liquid crystal 2,3,6,7,10,11-hexa(4‘-octyloxybenzoyloxy)-triphenylene (HOBT-C8) were investigated. Four phases having different orders and symmetries existed in this system: a discotic nematic phase, a rectangular columnar (ColR) phase, an orthorhombic crystalline (CrI) phase developed upon cooling, and a monoclinic crystalline (CrII) phase formed during heating (Tang, B. Y., et al. Mater. Chem. 2001, 13, 78). The CrI phase represented a metastable phase compared to the CrII phase. On the basis of the results of differential scanning calorimetry, wide-angle X-ray diffraction, and polarized light microscopy (PLM) experiments, three crystallization-temperature (Tc) regions were identified to help study the crystallization kinetics of the CrI and CrII phases. In the large Tc region below 114 °C (region III), the CrI phase formed first despite its metastable nature (monotropic) due to the faster crystallization kinetics of the ColR → CrI phase in this region. The CrI → CrII phase transformation then followed. However, when the Tc ≥ 115 °C in region I, which was close to the melting temperature (Tm) of the CrI phase (Tm = 121 °C), only the CrII phase formed directly from the ColR phase. In the narrow Tc region II where 114 °C ≤ Tc < 115 °C, primary nucleation and overall crystallization rates of CrI and CrII phases were reversed. Linear crystal growth rate measurements in PLM revealed that a minimum in the CrII phase growth rate was found in region II. This indicated that as long as the growth rates of both phases were similar and on the same growth front, the CrII phase formation could be hampered by the growth of the metastable CrI phase.
Intestinal Lesions Associated with Disseminated Candidiasis in an Experimental Animal Model (2000)

In human patients, disseminated candidiasis, a life-threatening disease for immunocompromised patients, is often associated with intestinal lesions. In this study, we demonstrate that immunosuppressed gnotobiotic (IGB) piglets orally inoculated with wild-typeCandida albicans developed extensive intestinal lesions and disseminated infection. Severe ulceration of the ileal mucosa was observed overlying regions of colonization and necrosis of the gut-associated lymphoid tissue. Despite the high susceptibility of IGB piglets to many microbial pathogens, an avirulent mutant strain ofC. albicans failed to produce intestinal lesions and exhibited poor dissemination, demonstrating that these effects required virulent organisms. It is likely that in IGB piglets, as in human patients, intestinal lesions provide the mechanism for escape ofC. albicans from the gastrointestinal tract. Multinucleated giant cells containing fungal organisms were observed within lymph nodes and lymphatic vessels, and as with other pathogens, such cells could provide a mechanism for dissemination of C. albicans.
ASIC Design for Wireless Surgical MEMS Device and Instrumentation (2006)

There is an increasing demand on computerized surgical instrumentation and implants that can acquire intra-operative or in-vivo data for surgeons and engineers. The sensory system is gaining complexity in order to obtain more accurate measurements. Although many off-the-shelf components and chips exist, multiple components are often required to achieve the desired function. Since space is limited in biomedical applications, application specific highly compacted integrated circuits are preferable. In this study, a chip is designed to process an array of microcantilever readout used in an intra-operative soft-tissue balancing instrument.
Quantum optics and quantum information processing with photonic crystal devices (2006)

We have demonstrated classical and quantum information processing devices enabled by strong light-matter interaction in photonic crystals, including quantum dot-photonic crystal single photon source, ultrafast photonic crystal nanocavity laser, and small quantum network on chip.
SRI-Sarnoff AURORA System at TRECVID 2013 Multimedia Event Detection and Recounting. (2013)

In Multimedia Event Detection 2013 evaluation, SRI Aurora team participated in EK100, EK10, and EK0 tasks with full system evaluation. We submitted 15 runs for both pre-specified events (PS-Events) and ad-hoc events (AH-Events). The majority of them achieved satisfactory results. In particular, thanks to the well-designed concept features, our EK10 system works consistently much better for both PSEvents and AH-Events. By creating the concept language model from the web source, we build our EK0 system to perform event detection without training examples. This system achieved promising results on PS-Events. In MER task, we developed an approach to provide a breakdown of the evidences of why the MED decision has been made by exploring the SVM-based event detector. Furthermore, we designed evidence specific verification and detection to reduce uncertainty and improve key evidence discovery.
Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment (2019)

One million patients with congenital heart disease (CHD) live in the United States. They have a lifelong risk of developing heart failure. Current concepts do not sufficiently address mechanisms of heart failure development specifically for these patients. Here, analysis of heart tissue from an infant with tetralogy of Fallot with pulmonary stenosis (ToF/PS) labeled with isotope-tagged thymidine demonstrated that cardiomyocyte cytokinesis failure is increased in this common form of CHD. We used single-cell transcriptional profiling to discover that the underlying mechanism of cytokinesis failure is repression of the cytokinesis gene ECT2, downstream of β-adrenergic receptors (β-ARs). Inactivation of the β-AR genes and administration of the β-blocker propranolol increased cardiomyocyte division in neonatal mice, which increased the number of cardiomyocytes (endowment) and conferred benefit after myocardial infarction in adults. Propranolol enabled the division of ToF/PS cardiomyocytes in vitro. These results suggest that β-blockers could be evaluated for increasing cardiomyocyte division in patients with ToF/PS and other types of CHD.
The .pi. nucleophilicity: the effect of charge delocalization on the efficiency of internal displacements in ElcB reactions (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe .pi. nucleophilicity: the effect of charge delocalization on the efficiency of internal displacements in ElcB reactionsShmaryahu Hoz, Zeev Gross, and D. CohenCite this: J. Org. Chem. 1985, 50, 6, 832–836Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/jo00206a022https://doi.org/10.1021/jo00206a022research-articleACS PublicationsRequest reuse permissionsArticle Views87Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Diencephalic amnesia: a reappraisal. (1976)

The anatomical basis of memory disorder related to lesions of the diencephalon is a controversial matter. A study of a patient who developed severe amnesia in association with bilateral metastatic tumour invasion of the medial and posterior thalamus is reported. The findings in this case have led to further discussion of this unsettled issue.
Fusing Competing Prediction Algorithms for Prognostics (2006)

Two fundamentally different approaches can be employed to estimate remaining life in faulted components. One is to model from first principles the physics of fault initiation and propagation. Such a model must include detailed knowledge of material properties, thermodynamic and mechanical response to loading, and the mechanisms for damage creation and growth. Alternatively, an empirical model of condition-based fault propagation rate can be developed using data from experiments in which the conditions are controlled or otherwise known and the component damage level is carefully measured. These two approaches have competing advantages and disadvantages. However, fusing the results of the two approaches produces a result that is more robust than either approach alone. In this paper, we introduce an approach to fuse competing prediction algorithms for prognostics. Results presented are derived from rig test data wherein multiple bearings were first seeded with small defects, then exposed to a variety of speed and load conditions similar to those encountered in aircraft engines, and run until the ensuing material liberation accumulated to a predetermined damage threshold or cage failure, whichever occurred first
Proteasome-Mediated Proteolysis of the Interleukin-10 Receptor Is Important for Signal Downregulation (2006)

The cytokine interleukin-10 (IL-10) is an important regulator of immune cell function, proliferation, and survival. The IL-10 receptor (IL-10R) consists of two subunits, IL-10R1 and IL-10R2, both belonging to the class II cytokine receptor superfamily. Like other members of the cytokine receptor superfamily, IL-10R stimulation leads to activation of Jak family kinases and Stat transcription factors. To identify additional signal transduction pathways used by the IL-10R, we purified 92-kDa and 100-kDa proteins that coprecipitated with IL-10R1 from IL-10-stimulated cells. Both proteins were found to be related to the 97-kDa subunit of the regulatory component of the 26S proteasome. Subsequent studies confirmed that the IL-10R1 undergoes ligand- dependent internalization and proteasome-mediated degradation. An IL-10R1 cytoplasmic domain mutant deficient for internalization exhibited prolonged signaling through Jak1 and Stat3, reinforcing the importance of receptor internalization for signal termination.
Corner field effect of the CMP oxide recess in shallow trench isolation technology for high density flash memories (2002)

This paper presents CMP oxide recess with corner field effect in STI technology for high density, sub-0.35 /spl mu/m flash memories. Trench corners with different shape have shown to correlate with CMP recess. We have shown for the first time that non-uniform CMP polish across wafer leads to broad V/sub t/ distribution. Corner field effect at trench edge may play a role. Analytical model based on energy band structure is simulated.
BDNF/TrkB axis activation promotes epithelial–mesenchymal transition in idiopathic pulmonary fibrosis (2017)

Our results suggest that BDNF/TrkB axis plays a role in EMT promoting the acquisition of (myo)fibroblast cell phenotype in IPF. Targeting BDNF/TrkB seems to represent a viable approach in order to prevent EMT dependent lung fibrosis.
Abstract S1-01: Whole exome and transcriptome sequencing of resistant ER+ metastatic breast cancer (2017)

Abstract Background: While great strides have been made in the treatment of estrogen receptor-positive (ER+) metastatic breast cancer (MBC), therapeutic resistance invariably occurs. A better understanding of the underlying resistance mechanisms is critical to enable durable control of this disease. Methods: We performed whole exome sequencing (WES) and transcriptome sequencing (RNA-seq) on metastatic tumor biopsies from 88 patients with ER+ MBC who had developed resistance to one or more ER-directed therapies. For 27 of these patients, we sequenced the treatment-naïve primary tumors for comparison to the resistant specimens. Tumors were analyzed for point mutations, insertions/deletions, copy number alterations, translocations, and gene expression. Detailed clinicopathologic data was collected for each patient and linked to the genomic information. Results: WES of all metastatic samples demonstrated several recurrently altered genes whose incidence differed significantly from primary, treatment-naïve ER+ breast cancers sequenced in the TCGA study (TCGA). These include ESR1 mutations (n=17, 19.3%; 32.86 fold enrichment, q.value&amp;lt;7.5e-12), CCND1 amplification (n=52, 59.1%; 2.3 fold enrichment, q.value&amp;lt;0.0073), and MAP2K4 biallelic inactivation (n=14, 15.9%; 3.04 fold enrichment, q.value&amp;lt; 0.054). Comparing to matched primary samples from the same patient, many alterations were found to be acquired in several cases, including for ESR1, ERBB2, PIK3CA, PTEN, RB1, AKT1, and others. Initial analysis of RNA-seq data from metastatic samples (n=59) allowed classification of individual resistance mechanisms into broader resistance modes based on the observed transcriptional state. Conclusions: We present a genomic landscape of resistant ER+ MBC using WES and RNA-seq. Multiple genes were recurrently altered in these tumors at significantly higher rates than in ER+ primary breast cancer. When compared with matched primary tumors from the same patient, alterations in these and other genes were often found to be acquired after treatment, suggesting a role in resistance to ER-directed therapies and/or metastasis. Potential resistance mechanisms appear to fall into several categories; integrating RNA-seq data may enhance the ability to identify these categories even when genomic alterations are not identified. Multiple clinically relevant genomic and molecular alterations are identified in metastatic biopsies– with implications for choice of next therapy, clinical trial eligibility, and novel drug targets. Citation Format: Cohen O, Kim D, Oh C, Waks A, Oliver N, Helvie K, Marini L, Rotem A, Lloyd M, Stover D, Adalsteinsson V, Freeman S, Ha G, Cibulskis C, Anderka K, Tamayo P, Johannessen C, Krop I, Garraway L, Winer E, Lin N, Wagle N. Whole exome and transcriptome sequencing of resistant ER+ metastatic breast cancer [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr S1-01.
A Single-Channel Noise Reduction Filtering/Smoothing Technique in the Time Domain (2018)

In this paper, we present a single-channel smoothing-and-filtering technique for noise reduction in the time domain. Unlike traditional noise reduction methods, which directly apply a noise reduction filter to the noisy signal, the developed technique achieves noise reduction in two steps. It first applies a time smoothing window to the noisy signal, which, on the one hand, can help reduce high frequency noise and, on the other hand, can help leverage the correlation between successive signal samples. A noise reduction filter is then applied to the smoothed noisy signal to estimate the speech signal of interest. Three optimal and suboptimal noise reduction filters are derived, including the Wiener, maximum signal-to-noise-ratio (SNR), and tradeoff filters. Simulation results reveal that the developed method can produce better noise reduction performance, i.e., higher gains in the perceptual-evaluation-of-speech-quality (PESQ) score, than the traditional methods without smoothing.
New auxiliary active lossless snubber-assisted full bridge soft switching PWM high frequency inverter-fed DC-DC power converter (2005)

This paper deals with a novel full bridge circuit topology of high frequency transformer isolated soft switching PWM inverter type DC/DC power converter. The zero voltage soft switching PWM DC/DC power converter employing an input DC rail series switch and parallel capacitor assisted by high frequency transformer parasitic component is proposed and developed for high performance TIG and MIG arc welding in industry. Its operating principle in stead state is described by introducing switching mode equivalent circuits. The operating performances of 32 V-300 A/60 kHz soft switching PWM inverter fed DC-DC power converter using IGBT module package are illustrated on the basis of experimental results along with its power loss analysis.
Comments on "Method of flow graph simplification for the 16-point discrete Fourier Transform" (2006)

The paper "Method of Flow Graph Simplification for the 16-Point Discrete Fourier Transform" by Grigoryan and Bhamidipati presents a "paired transform" fast Fourier transform (FFT) algorithm that is claimed to perform the size-8 and size-16 complex-data discrete Fourier transform (DFT) with 44 and 140 arithmetic operations, respectively. If true, this count would be less than the 56 and 168 operations achieved in the best pre-existing (split-radix) methods. Grigoryan and Bhamidipati's count of real additions is erroneous, however, and this comment shows that their algorithm actually has arithmetic complexity identical to that of standard split-radix algorithms.