gebhart/patrepeval huggingface dataset:
A silicon micromachined scanning thermal profiler with integrated elements for sensing and actuation (1997)

The thermal profiler is a scanning probe microscope with a miniature thermocouple (TC) at its tip which provides topographic and thermographic information by sensing heat conducted across a small air gap. The silicon micromachined thermal profilers (SMTPs) described in this paper are structurally comprised of a probe that can be longitudinally actuated by an integrated electrostatically driven suspension. A polysilicon-gold TC is located near the probe tip, which overhangs a glass substrate; a resistive heater is integrated with the base. An IC-compatible, 8-mask fabrication process has been developed and SMTPs with various types of frames and probes have been designed, fabricated, and thermally characterized. The maximum thermoelectric signal available from a 7-TC thermopile probe has been measured at 824 mV/W of input power to the heater, whereas from a simpler design it was 48 mV/W. Simple dithered and nondithered scans are presented to demonstrate the basic functionality of fabricated devices. The noise due to our test setup has been measured at /spl ap/20 mK. For a 1 /spl mu/m/spl times/0.5 /spl mu/m tip and a 0.1 /spl mu/m long air gap the spatial resolution and the device NETD have been theoretically estimated as /spl ap/3.33 nm and /spl ap/0.1 mK//spl radic/Hz, respectively.
Color-tunable multilayer organic light emitting diode composed of DNA complex and tris(8-hydroxyquinolinato)aluminum (2010)

In this study, the voltage-controlled color tunability of an organic light emitting diode composed of a DNA/Polyaniline/Ru(bpy)32+ complex (as the hole transport layer) and tris(8-hydroxyquinolinato)aluminum (as the electron transport layer) was demonstrated. At applied voltage of 5 V, green emission was observed from Alq3. As the voltage was increased, the emission color changed from green to yellow (14 V) to orange (16 V) and finally to red (18 V), with strong contribution of red emission from Ru(bpy)32+. This color tunability of the emission was principally a result of the shift in the carrier recombination region with an increase in applied voltage.
Inhibition of Adjuvant Arthritis by a DNA Vaccine Encoding Human Heat Shock Protein 60 (2002)

Adjuvant arthritis (AA) is an autoimmune disease inducible in rats involving T cell reactivity to the mycobacterial 65-kDa heat shock protein (HSP65). HSP65-specific T cells cross-reactive with the mammalian 60-kDa heat shock protein (HSP60) are thought to participate in the modulation of AA. In this work we studied the effects on AA of DNA vaccination using constructs coding for HSP65 (pHSP65) or human HSP60 (pHSP60). We found that both constructs could inhibit AA, but that pHSP60 was more effective than pHSP65. The immune effects associated with specific DNA-induced suppression of AA were complex and included enhanced T cell proliferation to a variety of disease-associated Ags. Effective vaccination with HSP60 or HSP65 DNA led paradoxically to up-regulation of IFN-gamma secretion to HSP60 and, concomitantly, to down-regulation of IFN-gamma secretion to the P180-188 epitope of HSP65. There were also variable changes in the profiles of IL-10 secretion to different Ags. However, vaccination with pHSP60 or pHSP65 enhanced the production of TGFbeta1 to both HSP60 and HSP65 epitopes. Our results support a regulatory role for HSP60 autoreactivity in AA and demonstrate that this control mechanism can be activated by DNA vaccination with both HSP60 or HSP65.
A Mild Dihydrobenzooxaphosphole Oxazoline/Iridium Catalytic System for Asymmetric Hydrogenation of Unfunctionalized Dialins (2014)

Abstract Air‐stable P‐chiral dihydrobenzooxaphosphole oxazoline ligands were designed and synthesized. When they were used in the iridium‐catalyzed asymmetric hydrogenation of unfunctionalized 1‐aryl‐3,4‐dihydronaphthalenes under one atmosphere pressure of H 2 , up to 99:1 e.r. was obtained. High enantioselectivities were also observed in the reduction of the exocyclic imine derivatives of 1‐tetralones.
Supplementary Table 1 from Phase I and Preliminary Phase II Study of TRC105 in Combination with Sorafenib in Hepatocellular Carcinoma (2023)

&lt;p&gt;Flow chart of dose level patient enrollment&lt;/p&gt;
Characterization of silicon on insulator substrates using reflection mode double-crystal X-ray topography (1991)

Abstract The strain distributions of various silicon-on-insulator (SOI) wafers were studied using Bragg reflection mode double-crystal topography analysis. These SOI samples included the separation by implanted oxygen (SIMOX), the zone melt recrystallization (ZMR), and the bond and etch-back silicon-on-insulator (BESOI). The inherent warpage of each SOI sample was revealed by X-ray double-crystal topography (DCT). Dislocation loops and surface-terminating defects were also observed on the ZMR sample. The defect density was evaluated by double-crystal rocking curve (DCRC) analysis using a symmetric (004) set-up. The relative peak intensities and full width at half maxima (FWHM) were measured. The quality of superficial silicon layers of most SOI wafers was similar to the quality of a single-crystal silicon, except the ZMR sample. According to these analyses, SIMOX wafers provide the best single-crystal quality and consistent lattice characteristics under various fabrication processes.
Luminescent Blinking from Silver Nanostructures. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Development of Approaches and Metrics to Measure the Impact and Improve the Clinical Outcomes of Patients With Frailty in the Era of COVID-19. The COMETA Italian Protocol (2022)

The outbreak of the coronavirus 2 disease 2019 (COVID-19) puts an enormous burden on healthcare systems worldwide. This may worsen outcomes in patients with severe chronic diseases such as cancer, autoimmune diseases, and immune deficiencies. In this critical situation, only a few available data exist, which do not allow us to provide practical guides for the treatment of oncological or immunocompromised patients. Therefore, a further step forward is needed, addressing the specific needs and demands of frail patients in the pandemic era. Here we aim to present a protocol of a study approved by an ethical committee named "CO.M.E.TA". CO.M.E.TA protocol is a network project involving six Italian institutions and its goals are: i) to measure and compare the impact of the pandemic on the access of cancer and immunocompromised patients to therapies in three Italian regions; ii) to assess how reorganizational measures put in place in these different institutions have impacted specific metrics of performance; iii) to establish a COVID-19 Biobank of biological samples from SARS-CoV-2 infected patients to be used to study immunological alterations in patients with immune frailty.
An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype (2020)

AbstractBackgroundThe genetics of depression has been explored in genome-wide association studies that focused on either major depressive disorder or depressive symptoms with mostly negative findings. A broad depression phenotype including both phenotypes has not been tested previously using a genome-wide association approach. We aimed to identify genetic polymorphisms significantly associated with a broad phenotype from depressive symptoms to major depressive disorder.MethodsWe analyzed two prior studies of 70,017 participants of European ancestry from general and clinical populations in the discovery stage. We performed a replication meta-analysis of 28,328 participants. Single nucleotide polymorphism (SNP)-based heritability and genetic correlations were calculated using linkage disequilibrium score regression. Discovery and replication analyses were performed using a p-value-based meta-analysis. Lifetime major depressive disorder and depressive symptom scores were used as the outcome measures.ResultsThe SNP-based heritability of major depressive disorder was 0.21 (SE = 0.02), the SNP-based heritability of depressive symptoms was 0.04 (SE = 0.01), and their genetic correlation was 1.001 (SE = 0.2). We found one genome-wide significant locus related to the broad depression phenotype (rs9825823, chromosome 3: 61,082,153, p = 8.2 × 10–9) located in an intron of the FHIT gene. We replicated this SNP in independent samples (p = .02) and the overall meta-analysis of the discovery and replication cohorts (1.0 × 10–9).ConclusionsThis large study identified a new locus for depression. Our results support a continuum between depressive symptoms and major depressive disorder. A phenotypically more inclusive approach may help to achieve the large sample sizes needed to detect susceptibility loci for depression.
Supplemental video 1 from ITPR1 Protects Renal Cancer Cells against Natural Killer Cells by Inducing Autophagy (2023)

&lt;p&gt;Supplemental video 1. 786-0 cells described in Figure 3B were recorded by time-lapse video microscopy&lt;/p&gt;
ChemInform Abstract: In vivo Protein—Protein Interaction Assays: Beyond Proteins (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Small molecule activation of m6A mRNA methylation as a novel approach for neuroprotection (2023)

Abstract N6-Methyladenosine (m6A) is the most common mRNA base modification in eukaryotes. Methylation of adenosine residues to m6A contributes to the regulation of splicing, transport, stability, and translation of mRNA and two main classes of enzymes regulate it. The formation of m6A is catalysed by a methyltransferase complex containing methyltransferase-like 3 (METTL3), METTL14, and Wilms’ tumour 1-associated protein (WTAP) as well as monomeric METTL16. Demethylation of m6A is catalysed by the fat mass and obesity-associated protein FTO and the RNA demethylase AlkB homolog 5 (ALKBH5). The m6A mRNA methylation dysregulation occurs in the nervous system and in Parkinson’s disease (PD), but it remains poorly studied. Moreover, the role of m6A mRNA methylation in neuronal survival, neuroprotection, and neuroregeneration is unclear. We have earlier used high-throughput virtual screening of large compound libraries and identified four unique small-molecule ligands that activate m6A mRNA methylation by binding to the METTL3/14/WTAP complex and enhancing the binding of the methylation substrate SAM to nanomolar concentrations. Following this, we now discovered that two methyltransferase activators at 10 nM concentrations supported the survival and protected dopamine (DA) neurons in culture in growth factor deprivation and 6-hydroxydopamine (6-OHDA) neurotoxin models. In contrast, METTL3/14 inhibitor STM2457 triggered death of DA neurons. For clinical translation we also tested the most efficient compound C4 on induced pluripotent stem cell-derived human DA neurons and in animal model of Parkinson’s disease (PD). C4 compound protected human DA neurons from 6-OHDA-induced cell death and increased neurite outgrowth and the number of processes demonstrating that it has both neuroprotective and neurorestorative properties. METTL3/14 activator C4 improved motor behaviour and protected DA neurons and their fibres faster and much more efficiently than GDNF in the rat 6-OHDA model of PD. These are the first specific activators of METTL3/14/WTAP and first demonstration that m6A regulators can protect and regenerate neurons. These data demonstrate that m6A mRNA methylation is a novel pathway regulating neuronal survival and regeneration.
A serialization graph construction for nested transactions (1990)

This paper makes three contributions. First, we present a proof technique that offers system designers the same ease of reasoning about nested transaction systems as is given by the classical theory for systems without nesting, and yet can be used to verify that a system satisfies the robust “user view” definition of correctness of [10]. Second, as applications of the technique, we verify the correctness of Moss' read/write locking algorithm for nested transactions, and of an undo logging algorithm that has not previously been presented or proved for nested transaction systems. Third, we make explicit the assumptions used for this proof technique, assumptions that are usually made implicitly in the classical theory, and therefore we clarify the type of system for which the classical theory itself can reliably be used.
Contamination Removal on FIB Nano-Patterned Surfaces (2006)

Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3, 2005
Anterior Column Realignment (ACR) in adult sagittal deformity correction (2016)

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Dynamics of solidification in Al thin films measured using a nanocalorimeter (2011)

We demonstrate how a nanocalorimeter can be used to measure the dynamics of thin film melting and solidification using aluminum as a model system. Recalescence, a rise in temperature due to enthalpy release on solidification, is observed when the rate of heat release is faster than the rate of heat extraction. For thin films, with a large density of nucleation centers at the interface, recalescence effects are observed at high cooling rates where direct measurements of heat capacities and enthalpy changes are challenging. Temperature rates of 104 K/s were applied using nanocalorimeter chips; the nanocalorimeter allows direct measurement of the under cooling, temperature rise during solidification, and the associated changes in enthalpy. This work highlights some of the challenges recalescence causes in physical measurements and provides a numerical strategy to evaluate enthalpy changes during rapid solidification.
Malmgården Karlstad - en arkitekturhistorisk och kulturhistorisk beskrivning (2001)

Malmgarden, uppford 1927-29, ar en tjugotalsklassicistisk byggnad i rott tegel. Den kom till pa ideell bas genom Foreningen for Pauvres Honteux. Huset omfattade fran borjan tjugo lagenheter avsedda ...
Power allocation policy for distributed estimation in wireless networks (2011)

We consider a sensor network monitoring a stochastic process. The sensors exchange information over wireless communication channels affected by noise. The goal of the sensors is to compute accurate estimates of the state of the stochastic process under limited energy available for communications. We introduce a distributed algorithm which computes a power allocation scheme aimed at ensuring accurate state estimates and at saving communication energy. The distributed algorithm arise from solving an approximate convex optimization problem with constraints. We present how the power allocation scheme can be used for performing distributed estimation in the case where measurements are shared between sensors.
Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures (2017)

Target-based approaches toward new antimalarial treatments are highly valuable to prevent resistance development. We report several series of pyrazolopyran-based inhibitors targeting the enzyme serine hydroxymethyltransferase (SHMT), designed to improve microsomal metabolic stability and to identify suitable candidates for in vivo efficacy evaluation. The best ligands inhibited Plasmodium falciparum (Pf) and Arabidopsis thaliana (At) SHMT in target assays and PfNF54 strains in cell-based assays with values in the low nanomolar range (3.2-55 nM). A set of carboxylate derivatives demonstrated markedly improved in vitro metabolic stability (t<sub>1/2</sub> > 2 h). A selected ligand showed significant in vivo efficacy with 73% of parasitemia reduction in a mouse model. Five new cocrystal structures with PvSHMT were solved at 2.3-2.6 Å resolution, revealing a unique water-mediated interaction with Tyr63 at the end of the para-aminobenzoate channel. They also displayed the high degree of conformational flexibility of the Cys364-loop lining this channel.
Rejection of Impassable Substrates by Yersinia Type III Secretion Machines (2005)

Type III machines of pathogenic Yersinia spp. transport Yop proteins across the bacterial envelope into host cells. Translational fusions of yopE to the dihydrofolate reductase gene (dhfr) or the beta-galactosidase gene (lacZ) generate hybrid proteins that block type III injection of Yop proteins into host cells, consistent with the canonical view that impassable DHFR and LacZ hybrids jam secretion machines. Mutations in repressors of posttranscriptional gene regulation, Yersinia enterocolitica yscM1 and yscM2 as well as Yersinia pestis lcrQ, relieve the YopE-DHFR-imposed blockade and restore type III injection into host cells. Genetic suppression of the type III blockade does not, however, promote YopE-DHFR secretion. A model is proposed whereby rejection of YopE-DHFR from the secretion pathway inhibits type III gene expression.
Teaching silicon photonics using new technologies (2022)

To improve student learning experience in several photonics modules we teach at the University of Southampton, we use software packages for photonic circuit simulation and design, our cleanroom complex for the fabrication of the designed circuits, and experimental labs that we have developed for the characterization.
Nonclassical number-phase correlation in semiconductor lasers (2000)

Summary form only given. Optical phase is conjugate to the photon-number in quantum optics and therefore is important for nonclassical states in which the photon-number operator is reduced below the semiclassical shot noise limit, i.e., for photon-number squeezed states. Nonclassical emission from semiconductor lasers has the added facet that excess phase fluctuations are correlated with fluctuations in the photon-number through the nonlinear gain, and this correlation extends below shot noise. In this experiment, quantum-limited number-phase correlations are examined using an external-cavity semiconductor laser with heavily suppressed (>40 dB) side modes and near ideal single-mode laser characteristics. A feedforward gain matching condition is found to limit the observation of a strong nonclassical effect.
12C-2 Improved Accuracy of Broadband Ultrasound Attenuation Measurement Using Phase Insensitive Detection: Results in 73 Women (2007)

Broadband ultrasonic attenuation (BUA) is a clinically-accepted measurement for diagnosis of osteoporosis. Typical clinical BUA measurements are performed with phase sensitive receivers and therefore can be affected by phase cancellation. In order to separate the effects of conventional attenuation (absorption plus scattering) from phase cancellation, BUA was measured on phantoms with acrylic wedge phase aberrators and on 73 women using both phase sensitive (PS) and phase insensitive (PI) reception. A clinical bone sonometer (GE Lunar Achilles Insight reg) with a two dimensional receiver array was used. PI BUA measurements on phantoms with acrylic wedge phase aberrators were found to be far more resistant to phase cancellation than PS BUA measurements. In data from 73 women, means and standard deviations for BUA measurements were 81.4 plusmn 21.4 dB/MHz (PS) and 67.2 plusmn 9.7 dB/MHz (PI).
Design methodology for a very high frequency resonant boost converter (2010)

This document introduces a design methodology for a resonant boost converter topology that is suitable for operation at very high frequencies. The topology we examine features a low parts count and fast transient response but suffers from higher device stresses compared to other topologies that use a larger number of passive components. A numerical design procedure is developed for this topology that does not rely on time-domain simulation sweeps across parameters. This allows the optimal converter design to be found for a particular main semiconductor switch. If an integrated power process is used where the designer has control over layout of the semiconductor switch, the optimal combination of converter design and semiconductor layout can be found. To validate the proposed converter topology and design approach, a 75 MHz prototype converter is designed and experimentally demonstrated. The performance of the prototype closely matches that predicted by the design procedure, and achieves good efficiency over a wide input voltage range.
Tissue-Engineered Heart Valve with a Tubular Leaflet Design for Minimally Invasive Transcatheter Implantation (2014)

Transcatheter aortic valve implantation of (nonviable) bioprosthetic valves has been proven a valid alternative to conventional surgical implantation in patients at high or prohibitive mortality risk. In this study we present the in vitro proof-of-principle of a newly developed tissue-engineered heart valve for minimally invasive implantation, with the ultimate aim of adding the unique advantages of a living tissue with regeneration capabilities to the continuously developing transcatheter technologies. The tube-in-stent is a fibrin-based tissue-engineered valve with a tubular leaflet design. It consists of a tubular construct sewn into a self-expandable nitinol stent at three commissural attachment points and along a circumferential line so that it forms three coaptating leaflets by collapsing under diastolic back pressure. The tubular constructs were molded with fibrin and human umbilical vein cells. After 3 weeks of conditioning in a bioreactor, the valves were fully functional with unobstructed opening (systolic phase) and complete closure (diastolic phase). Tissue analysis showed a homogeneous cell distribution throughout the valve's thickness and deposition of collagen types I and III oriented along the longitudinal direction. Immunohistochemical staining against CD31 and scanning electron microscopy revealed a confluent endothelial cell layer on the surface of the valves. After harvesting, the valves underwent crimping for 20 min to simulate the catheter-based delivery. This procedure did not affect the valvular functionality in terms of orifice area during systole and complete closure during diastole. No influence on the extracellular matrix organization, as assessed by immunohistochemistry, nor on the mechanical properties was observed. These results show the potential of combining tissue engineering and minimally invasive implantation technology to obtain a living heart valve with a simple and robust tubular design for transcatheter delivery. The effect of the in vivo remodeling on the functionality of the tube-in-stent valve remains to be tested.