gebhart/patrepeval huggingface dataset:
Separation of bulk and interface contributions to electroforming and resistive switching behavior of epitaxial Fe-doped SrTiO3 (2009)

We succeeded in the separation of bulk and interface contributions to the electroforming and resistive switching behavior of Pt/STO(Fe)/Nb:STO devices by performing impedance spectroscopy. Two distinctive features observed in the impedance spectra could be assigned to the STO(Fe) bulk and to the depletion layer of the Pt/STO(Fe) Schottky contact. We attribute the resistance change during the dc forming process to a local bypassing of the depletion layer caused by oxygen effusion to the environment. By comparing the impedance spectra in the resistive “on” and “off” states, we propose that the resistance of the STO(Fe)/Nb:STO interface locally changes during the switching process.
Supplementary Figure 3 from Cisplatin Selects for Multidrug-Resistant CD133<sup>+</sup> Cells in Lung Adenocarcinoma by Activating Notch Signaling (2023)

&lt;p&gt;PDF file - 289K, Carboplatin induced DNA damage and CD133+ cell enrichment&lt;/p&gt;
Internal Waves' Role in Determining Probability Distribution of Coherent Integration Time Near 133 Hz and 3709 km in North Pacific Ocean (2011)

The hypothesis tested is that internal gravity waves limit the coherent integration time of sound at 3709 km in the Pacific ocean at 133 Hz and a pulse resolution of 0.06 s. Five days of continuous transmissions at 2-min intervals are examined. The source and the receiver are mounted on the bottom of the ocean with timing governed by atomic clocks. Measured variability is only due to fluctuations in the ocean. A model for the propagation of sound through fluctuating internal waves is run without any tuning with data. Excellent resemblance is found between the model and data's probability distributions of integration time up to a day, which is the largest lag explored. The probability that the integration exceeds a day or more is about 0.15. The model underpredicts the probability of occurrence of integration times shorter than 10 min. However, the overwhelming agreement at longer times supports the conclusion that the standard spectrum of internal waves accurately explains almost all of the distribution of measured integration time.
Plastid Genotyping Reveals Uniformity of cms-T Maize Cytoplasms (2015)

Cytoplasmic male-sterile (CMS) lines in maize (Zea mays) have been classified by their response to specific restorer genes into three categories: cms-C, cms-S, and cms-T. A mitochondrial genome representing each of the CMS cytotypes has been sequenced, and male sterility in the cms-S and cms-T cytotypes is linked to chimeric mitochondrial genes. To identify markers for plastid genotyping, we sequenced the plastid genomes of three fertile maize lines (B37, B73, and A188) and the B37 cms-C, cms-S, and cms-T cytoplasmic substitution lines. We found that the plastid genomes of B37 and B73 lines are identical. Furthermore, the fertile and CMS plastid genomes are conserved, differing only by zero to three single-nucleotide polymorphisms (SNPs) in coding regions and by eight to 22 SNPs and 10 to 21 short insertions/deletions in noncoding regions. To gain insight into the origin and transmission of the cms-T trait, we identified three SNPs unique to the cms-T plastids and tested the three diagnostic SNPs in 27 cms-T lines, representing the HA, I, Q, RS, and T male-sterile cytoplasms. We report that each of the tested 27 cms-T group accessions have the same three diagnostic plastid SNPs, indicating a single origin and maternal cotransmission of the cms-T mitochondria and plastids to the seed progeny. Our data exclude exceptional pollen transmission of organelles or multiple horizontal gene transfer events as the source of the mitochondrial urf13-T (unidentified reading frame encoding 13-kD cms-T protein) gene in the cms-T cytoplasms. Plastid genotyping enables a reassessment of the evolutionary relationships of cytoplasms in cultivated maize.
Pulse shortening and distortion in BWO and TWT microwave tubes (1999)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Dan M. Goebel; Pulse shortening and distortion in BWO and TWT microwave tubes. AIP Conf. Proc. 7 May 1999; 474 (1): 249–260. https://doi.org/10.1063/1.59016 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Inhibition of HIV-1 infection by alkylureas (1991)

The risk of infection by HIV-1 through transfusion of contaminated blood products has been markedly decreased but not eliminated by serological screening of donors. Methods are required to further minimize or eliminate the risk of infection of blood product recipients. We therefore examined the capacity of alkylureas to inhibit infectivity of HIV-1. Incubation of free HIV-1 virions with alkylureas suppressed their infectivity, and the minimal inhibitory concentration of the alkylureas was related to the length of the alkyl chain. Butylurea, the most potent inhibitor of HIV-1, inhibited the infectivity of 10(5) median tissue culture infective dose (TCID)50 of HIV-1, chronically HIV-1-infected H9 cells and mononuclear cells from two HIV-1-infected patients. Size fractionation of HIV-1 following incubation with butylurea indicated that the structure of the virus was disrupted by butylurea. This study demonstrates that butylurea, at a concentration that has been shown not to affect red blood cell function, can inhibit infectivity of extracellular and intracellular HIV-1. Since the HIV-1 inhibitory capacity of the alkylureas increases with the length of the alkyl side chain, it is likely that hydrophobic interactions between the alkylureas and HIV-1 are responsible for the observed effect.
Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells (2005)

Emery-Dreifuss muscular dystrophy can be caused by mutations in the nuclear envelope proteins lamin A/C and emerin. We recently demonstrated that A-type lamin-deficient cells have impaired nuclear mechanics and altered mechanotransduction, suggesting two potential disease mechanisms (Lammerding, J., P.C. Schulze, T. Takahashi, S. Kozlov, T. Sullivan, R.D. Kamm, C.L. Stewart, and R.T. Lee. 2004. J. Clin. Invest. 113:370-378). Here, we examined the function of emerin on nuclear mechanics and strain-induced signaling. Emerin-deficient mouse embryo fibroblasts have abnormal nuclear shape, but in contrast to A-type lamin-deficient cells, exhibit nuclear deformations comparable to wild-type cells in cellular strain experiments, and the integrity of emerin-deficient nuclear envelopes appeared normal in a nuclear microinjection assay. Interestingly, expression of mechanosensitive genes in response to mechanical strain was impaired in emerin-deficient cells, and prolonged mechanical stimulation increased apoptosis in emerin-deficient cells. Thus, emerin-deficient mouse embryo fibroblasts have apparently normal nuclear mechanics but impaired expression of mechanosensitive genes in response to strain, suggesting that emerin mutations may act through altered transcriptional regulation and not by increasing nuclear fragility.
Endogenous Sex Hormone Changes in Postmenopausal Women in the Diabetes Prevention Program (2012)

Among postmenopausal glucose-intolerant women not using estrogen, ILS increased SHBG levels and lowered DHEA levels. These changes were associated with lower glucose independent of adiposity and insulin. Metformin effects upon ESH were not significant.
Micropublication: incentivizing community curation and placing unpublished data into the public domain (2018)

www.micropublication.org.
Inside Cover: Exploring Ultrafast Photoswitching Pathways in RbMnFe Prussian Blue Analogue (Angew. Chem. Int. Ed. 43/2021) (2021)

Femtosecond optical spectroscopy and DFT calculations are used by Hiroko Tokoro, Shin-ichi Ohkoshi, Eric Collet, and co-workers in their Research Article on page 23267 to investigate photomagnetism in the RbMnFe material. Two photoswitching pathways with different dynamics are found. The initial electronic excitation may launch first the reverse Jahn–Teller distortion or the intervalence Fe–Mn charge transfer.
Les marchés des biens politiques et symboliques en comparaison dans des contextes centralisés et fédéraux (2015)

International audience
Identification of the fungal catabolic D-galacturonate pathway (2010)

Pectin is a natural polymer consisting mainly of D-galacturonic acid monomers. Microorganisms living on decaying plant material can use D-galacturonic acid for growth. Although bacterial pathways for D-galacturonate catabolism had been described previously, no eukaryotic pathway for D-galacturonate catabolism was known at the beginning of this work. The aim of this work was to identify such a pathway.\n\nIn this thesis the pathway for D-galacturonate catabolism was identified in the filamentous fungus Trichoderma reesei. The pathway consisted of four enzymes: NADPH-dependent D-galacturonate reductase (GAR1), L-galactonate dehydratase (LGD1), L-threo-3-deoxy-hexulosonate aldolase (LGA1) and NADPH-dependent glyceraldehyde reductase (GLD1). In this pathway D-galacturonate was converted to pyruvate and glycerol via L-galactonate, L-threo-3-deoxy-hexulosonate and L-glyceraldehyde.\n\nThe enzyme activities of GAR1, LGD1 and LGA1 were present in crude mycelial extract only when T. reesei was grown on D-galacturonate. The activity of GLD1 was equally present on all the tested carbon sources. The corresponding genes were identified either by purifying and sequencing the enzyme or by expressing genes with homology to other similar enzymes in a heterologous host and testing the activities. The new genes that were identified were expressed in Saccharomyces cerevisiae and resulted in active enzymes. The GAR1, LGA1 and GLD1 were also produced in S. cerevisiae as active enzymes with a polyhistidine-tag, and purified and characterised. GAR1 and LGA1 catalysed reversible reactions, whereas only the forward reactions were observed for LGD1 and GLD1. When gar1, lgd1 or lga1 was deleted in T. reesei the deletion strain was unable to grow with D-galacturonate as the only carbon source, demonstrating that all the corresponding enzymes were essential for D-galacturonate catabolism and that no alternative D-galacturonate pathway exists in T. reesei.\n\nA challenge for biotechnology is to convert cheap raw materials to useful and more valuable products. Filamentous fungi are especially useful for the conversion of pectin, since they are efficient producers of pectinases. Identification of the fungal D-galacturonate pathway is of fundamental importance for the utilisation of pectin and its conversion to useful products.
On small signal equivalent circuit models for quantum dots (2017)

Summary In this paper, we introduce small signal equivalent circuit models for quantum dots at equilibrium driven by classical electromagnetic fields. We investigate both an isolated quantum dot and a pair of interacting quantum dots coupled by the electric dipole–dipole interaction. In particular, we derive the impulse responses of the equivalent circuit elements from the density operator of the quantum dots. The use of equivalent circuit elements for complex systems of quantum dots may greatly simplify the analysis and the design of light‐matter interaction processes at the nanoscale. Copyright © 2017 John Wiley &amp; Sons, Ltd.
Selective growth of SWNTs on partially reduced monometallic cobalt catalyst (2010)

SiO(2) supported cobalt (Co) catalyst could be partially reduced and anchored by unreduced Co ions during a carbon monoxide (CO) chemical vapor deposition (CVD) process. This resulted in the formation of sub-nanometre metallic Co clusters catalyzing the growth of single-walled carbon nanotubes (SWNTs) with a narrow diameter distribution.
Supplementary Movie SM3 from Tumor-Penetrating iRGD Peptide Inhibits Metastasis (2023)

&lt;p&gt;Supplementary Movie SM3. Tumor cell repulsion from iRGD silver nanoparticles&lt;/p&gt;
Computationally-inspired discovery of an unsymmetrical porous organic cage (2018)

A completely unsymmetrical porous organic cage was synthesised from a C<sub>2v</sub> symmetrical building block that was identified by a computational screen. The cage was formed through a 12-fold imine condensation of a tritopic C<sub>2v</sub> symmetric trialdehyde with a ditopic C<sub>2</sub> symmetric diamine in a [4 + 6] reaction. The cage was rigid and microporous, as predicted by the simulations, with an apparent Brunauer-Emmett-Teller surface area of 578 m<sup>2</sup> g<sup>-1</sup>. The reduced symmetry of the tritopic building block relative to its topicity meant there were 36 possible structural isomers of the cage. Experimental characterisation suggests a single isomer with 12 unique imine environments, but techniques such as NMR could not conclusively identify the isomer. Computational structural and electronic analysis of the possible isomers was used to identify the most likely candidates, and hence to construct a 3-dimensional model of the amorphous solid. The rational design of unsymmetrical cages using building blocks with reduced symmetry offers new possibilities in controlling the degree of crystallinity, porosity, and solubility, of self-assembled materials.
Microfluidic serial digital to analog pressure converter for arbitrary pressure generation and contamination-free flow control (2013)

Multilayer microfluidics based on PDMS (polydimethylsiloxane) soft lithography have offered parallelism and integration for biological and chemical sciences, where reduction in reaction volume and consistency of controlled variables across experiments translate into reduced cost, increased quantity and quality of data. One issue with push up or push down microfluidic control concept is the inability to provide multiple control pressures without adding more complex and expensive external pressure controls. We present here a microfluidic serial DAC (Digital to Analog Converter) that can be integrated with any PDMS device to expand the device's functionality by effectively adding an on-chip pressure regulator. The microfluidic serial DAC can be used with any incompressible fluids and operates in a similar fashion compared to an electronic serial DAC. It can be easily incorporated into any existing multilayer microfluidic devices, and the output pressure that the device generates could be held for extensive times. We explore in this paper various factors that affect resolution, speed, and linearity of the DAC output. As an application, we demonstrate microfluidic DAC's ability for on-chip manipulation of flow resistance when integrated with a simple flow network. In addition, we illustrate an added advantage of using the microfluidic serial DAC in preventing back flow and possible contamination.
Propagation of innovative information in non-linear least-squares structure from motion (2002)

We present a new technique that improves upon existing structure from motion (SFM) methods. We propose a SFM algorithm that is both recursive and optimal. Our method incorporates innovative information from new frames into an existing solution without optimizing every camera pose and scene structure parameter. To do this, we incrementally optimize larger subsets of parameters until the error is minimized. These additional parameters are included in the optimization by tracing connections between points and frames. In many cases, the complexity of adding a frame is much smaller than full bundle adjustment of all the parameters. Our algorithm is best described us incremental bundle adjustment as it allows new information to be added to art existing non-linear least-squares solution.
Flame Transfer Matrices of a Premixed Flame and a Global Check With Modelling and Experiments (2008)

In this paper alternative ways to obtain the thermo-acoustical characteristics of perfectly premixed flames given by their flame transfer matrix (FTM) is investigated. In particular a model based data reduction procedure which greatly reduces the experimental effort and therefore enables to provide this flame data for many more operation points than previously possible is proposed and validated. It is shown how the acoustic pressure field measured from two forcing states using the multi microphone method leads to the determination of the direct experimental FTM. The next relatively simpler method shown is the hybrid method which is based on Rankine-Hugoniot relations and the experimental flame transfer function (FTF) from OH*-chemiluminescence measurements for heat release fluctuations. Later to obtain the FTM using a network model based on Rankine-Hugoniot relations and an n-τ-σ FTF model representing the flame by regression analysis of the acoustical measurements is presented. Experimental results for the direct experimental FTM and the hybrid FTM are compared with the model based result. The results indicate very good consistency between the direct, hybrid and model based techniques providing a global check of the methods/tools used for analysing the thermoacoustic mechanisms of flames.
CEST theranostics: label-free MR imaging of anticancer drugs (2016)

Image-guided drug delivery is of great clinical interest. Here, we explored a direct way, namely CEST theranostics, to detect diamagnetic anticancer drugs simply through their inherent Chemical Exchange Saturation Transfer (CEST) MRI signal, and demonstrated its application in image-guided drug delivery of nanoparticulate chemotherapeutics. We first screened 22 chemotherapeutic agents and characterized the CEST properties of representative agents and natural analogs in three major categories, i.e., pyrimidine analogs, purine analogs, and antifolates, with respect to chemical structures. Utilizing the inherent CEST MRI signal of gemcitabine, a widely used anticancer drug, the tumor uptake of the i.v.-injected, drug-loaded liposomes was successfully detected in CT26 mouse tumors. Such label-free CEST MRI theranostics provides a new imaging means, potentially with an immediate clinical impact, to monitor the drug delivery in cancer.
Natural Nitrogen-Doped Carbon Dots Obtained from Hydrothermal Carbonization of Chebulic Myrobalan and Their Sensing Ability toward Heavy Metal Ions (2023)

Chebulic Myrobalan is the main ingredient in the Ayurvedic formulation Triphala, which is used for kidney and liver dysfunctions. Herein, natural nitrogen-doped carbon dots (NN-CDs) were prepared from the hydrothermal carbonization of Chebulic Myrobalan and were demonstrated to sense heavy metal ions in an aqueous medium. Briefly, the NN-CDs were developed from Chebulic Myrobalan by a single-step hydrothermal carbonization approach under a mild temperature (200 °C) without any capping and passivation agents. They were then thoroughly characterized to confirm their structural and optical properties. The resulting NN-CDs had small particles (average diameter: 2.5 ± 0.5 nm) with a narrow size distribution (1-4 nm) and a relatable degree of graphitization. They possessed bright and durable fluorescence with excitation-dependent emission behaviors. Further, the as-synthesized NN-CDs were a good fluorometric sensor for the detection of heavy metal ions in an aqueous medium. The NN-CDs showed sensitive and selective sensing platforms for Fe<sup>3+</sup> ions; the detection limit was calculated to be 0.86 μM in the dynamic range of 5-25 μM of the ferric (Fe<sup>3+</sup>) ion concentration. Moreover, these NN-CDs could expand their application as a potential candidate for biomedical applications and offer a new method of hydrothermally carbonizing waste biomass.
Integrated Advanced Reciprocating Internal Combustion Engine System for Increased Utilization of Gaseous Opportunity Fuels (2013)

The project is addressing barriers to or opportunities for increasing distributed generation (DG)/combined heat and power (CHP) use in industrial applications using renewable/opportunity fuels. This project brings together novel gas quality sensor (GQS) technology with engine management for opportunity fuels such as landfill gas, digester gas and coal bed methane. By providing the capability for near real-time monitoring of the composition of these opportunity fuels, the GQS output can be used to improve the performance, increase efficiency, raise system reliability, and provide improved project economics and reduced emissions for engines used in distributed generation and combined heat and power.
Synthesis and Structure−Activity Relationship Study of Potent Cytotoxic Analogues of the Marine Alkaloid Lamellarin D (2006)

The marine alkaloid, Lamellarin D (Lam-D), has shown potent cytotoxicity in numerous cancer cell lines and was recently identified as a potent topoisomerase I inhibitor. A library of open lactone analogues of Lam-D was prepared from a methyl 5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate scaffold (1) by introducing various aryl groups through sequential and regioselective bromination, followed by Pd(0)-catalyzed Suzuki cross-coupling chemistry. The compounds were obtained in a 24-44% overall yield, and tested in a panel of three human tumor cell lines, MDA-MB-231 (breast), A-549 (lung), and HT-29 (colon), to evaluate their cytotoxic potential. From these data, the SAR study concluded that more than 75% of the open-chain Lam-D analogues tested showed cytotoxicity in a low micromolar GI50 range.
Fast and continuous processing of a new sub-micronic lanthanide-based metal–organic framework (2014)

One phase – two processes – two magnitudes for synthesis time and the particle size.
New elements of the RSFQ logic family (1991)

In this report, new rapid single-flux quantum (RSFQ) elements (OR-AND, NOR-AND, half adder, multiplexer, demultiplexer, and shift registers) are presented. Operation of these gates has been studied with the help of the personal superconductor circuit analyzer (PSCAN) within the standard RSJ model of Josephson junctions. Parameter margins and other performance limits of the new elements are thoroughly investigated.
Hierarchical Load Testing Architecture using Large Scale Virtual Clients (2006)

In this work, we develop a hierarchical load testing architecture using large scale virtual clients to reduce the testing time and ensure the stability of the server for distributed applications. It explicitly secures the stability of the servers for networked virtual environment and at the same time, it elaborately generates actual loads for testing the performance of the servers. Our agent based load testing architecture provides variety of interactions of virtual entities in the virtual worlds to perform realistic simulations. Simulation results illustrate that our proposed architecture ensures the stability and capacity of the servers for both massively multiplayer online games and peer-to-peer network games