gebhart/patrepeval huggingface dataset:
MAPPI-DAT: data management and analysis for protein–protein interaction data from the high-throughput MAPPIT cell microarray platform (2017)

Supplementary data are available at Bioinformatics online.
Evaluation of droop-based controls in an islanded microgrid with electronically interfaced distributed energy resources (2015)

This paper compares the performance of different droop-based control techniques in an islanded microgrid that operates solely on electronically interfaced distributed energy resources (DERs). Specifically, the following techniques are compared: conventional droop-based control including a full pulse width modulating (PWM)-based voltage source converter (VSC) with power, voltage and current controls; adaptive decentralized droop controls that are built upon conventional droop controls with extra feedback loops; angle droop controls that operate based on drooping the power angle instead of the frequency; and a proposed hybrid controller that merges the advantages of both the adaptive decentralized droop controller and the angle droop controller. The performance of these control techniques in an isolated microgrid is evaluated through time domain simulations that are carried out in PSCAD/EMTDC on a sample test system.
PI-RADS Version 2 Category on 3 Tesla Multiparametric Prostate Magnetic Resonance Imaging Predicts Oncologic Outcomes in Gleason 3 + 4 Prostate Cancer on Biopsy (2018)

A PI-RADS version 2 category 5 lesion in patients with a biopsy Gleason score 3 + 4 lesion predicted adverse pathology features and biochemical recurrence-free survival. These findings suggest that preoperative 3 Tesla multiparametric magnetic resonance imaging may serve as a prognostic marker of treatment outcomes independently of biopsy Gleason score or biopsy type.
Effect of biopsy on the MRI radiomics classification of benign lesions and luminal A cancers (2018)

Radiomic features extracted from breast magnetic resonance (MR) images have demonstrated potential in diagnosis and prognosis of breast cancer. However, presentation of lesions on MRI may be affected by a biopsy event. We investigated, relative to biopsy condition, the difference in radiomic features and performance (the area under the receiver operating curve (AUC)) for the task of distinguishing between benign lesions and luminal A cancers. Dynamic contrast-enhanced MR images were collected retrospectively under IRB/HIPAA compliance. The 361-case dataset included 92 benign and 30 luminal A lesions imaged pre-biopsy and 40 benign and 199 luminal A lesions imaged post-biopsy. Thirty-four radiomic non-size features were extracted and their values compared for each group of lesions by biopsy condition using the Kolmogorov-Smirnov test to determine if the two groups were drawn from the same patient distribution. For each feature by biopsy condition, the median of the AUC and the confidence interval for the difference in AUC were determined (2000 bootstrap iterations). In all analyses, after correction for multiple comparisons, a difference was considered significant when the p-value was less than 0.0015 (0.05/34) or, equivalently, the 99.85% confidence interval for the difference excluded zero. If comparisons failed to meet p &lt; 0.0015, features were considered potentially robust. While, as expected, the morphology feature of irregularity was significantly different (p = 0.0003) for benign lesions due to how biopsy events increased irregularity of benign lesions, most features were potentially robust between biopsy conditions. While features did well in distinguishing between luminal A and benign lesions, all failed to demonstrate significance differences in AUC between biopsy conditions.
Diffraction characteristics of three-dimensional crossed-beam volume gratings (1980)

The theory of diffraction by gratings formed by the interference of two crossed three-dimensional “arbitrary-profile plane waves” in a photosensitive medium is developed. The detailed diffraction characteristics for the case of crossed-beam gratings formed by two three-dimensional “Gaussian plane waves” are presented. The diffraction efficiencies of these gratings and the profiles of the transmitted and diffracted beams are calculated as functions of the grating strength. The influence of the relative size (the Gaussian beam diameter) of the two writing beams on the diffraction efficiency is determined. Diffraction characteristics for readout with beams of profiles different from those used for writing are presented.
PiggyBac Enhanced Transgenesis and Transfection (2007)

We have developed an active form of transgenesis known as Enhanced Transgenesis (E‐TR) through augmenting transgene integration via recombinases and transposases. Our efforts have focused on Enhanced Intracytoplasmic Sperm‐Mediated Transgenesis (E‐ICSI‐TR) utilizing Tn5 and more recently piggyBac transposon. We have constructed a piggyBac single plasmid containing both the donor and helper elements. In transfection experiments, we demonstrated a transpositional efficiency of 3.8% and a relative fold increase of 9.4 in HEK293 cells. When utilizing piggyBac E‐ICSI‐TR, we were able to produce transgenic mice comparable to lentiviral methods, i.e. 22.8% of oocytes injected and 69.2% of the animals born. All the transgenic animals obtained were mosaics, because transcription of the transposase driven by the CAG promoter likely did not occur until after the one cell stage. We have now extended the research to inject piggyBac transposase cRNA together with the donor only plasmid into oocytes during ICSI to overcome mosaicism.
ChemInform Abstract: A NOVEL POTASSIUM HYDRIDE INDUCED REORGANIZATION REACTION. SYNTHESIS OF CONDENSED HETEROCYCLES (1978)

Abstract N‐Acetylpyrrol (I) und Allen‐1,3‐dicarbonsäureester (II) ergeben das Diels‐Alder‐Addukt (III), das mit KH über diskutierte Zwischenstufen zum Oxindolcarbonsäureester (IV) umgelagert wird.
Residual Coding for Transform Skip Mode in Versatile Video Coding (2020)

The support for screen content coding has received more attention with the latest development in video compression, the upcoming Versatile Video Coding (VVC) standard. Among the dedicated screen content coding tools, the transform skip mode (TSM) represents a promising approach for improving the coding efficiency at a low impact on implementation complexity. In this work, we present a dedicated residual coding for transform blocks coded in TSM. Due to the lack of the energy compaction of the transform, the quantization indexes for blocks coded in TSM have different statistical properties, which can be exploited in the entropy coding. Our coding experiments with screen content sequences yielded bit-rate savings of 3.9% for intra-only coding and 2.8% for typical random access configurations.
Application of the Semi-Loof Thin Shell Element to the Analysis of Aircraft Engine Structures (1981)

Most gas turbine engine structures consist of thin shells with multiple junctions. The curved isoparametric shell element gives unsatisfactory results when used for very thin shells. The Semi-Loof shell element was developed especially to deal with thin shell structures with sharp corners and multiple junctions. The Semi-Loof shell program was used at P&amp;WC for the analysis of large engine structures. Application to the analysis of an engine static structural model, for which experimental data are also available, has confirmed the efficiency of the Semi-Loof shell element in comparison with the conventional isoparametric element.
Examples (2018)

No AccessInjection Molding Processing DataNov 2018ExamplesAlberto Naranjo C., Maria del Maria del, Juan Diego Sierra M., Juan Rodrigo Sanz, Tim A. OsswaldAlberto Naranjo C., Maria del Maria del, Juan Diego Sierra M., Juan Rodrigo Sanz, Tim A. Osswaldhttps://doi.org/10.3139/9781569906675.004SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2018Pages: 24-36Print ISBN: 978-1-56990-666-8eISBN: 978-1-56990-667-5 Copyright & Permissions© 2019 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
-PPI: Searching Information Networks with Quantitative Privacy Guarantee (2014)

In information sharing networks, having a privacy preserving index (or PPI) is critically important for providing efficient search on access controlled content across distributed providers while preserving privacy. An understudied problem for PPI techniques is how to provide controllable privacy preservation, given the innate difference of privacy of the different content and providers. In this paper we present a configurable privacy preserving index, coined ǫ-PPI, which allows for quantitative privacy protection levels on fine-grained data units. We devise a new common-identity attack that breaks existing PPI’s and propose an identity-mixing protocol against the attack in ǫ-PPI. The proposed ǫ-PPI construction protocol is the first without any trusted third party and/or trust relationship between providers. We have implemented our ǫ-PPI construction protocol by using generic MPC techniques (secure multi-party computation) and optimized the performance to a practical level by minimizing the costly MPC computation part.
Figure S4 from Autocrine Adenosine Regulates Tumor Polyfunctional CD73<sup>+</sup>CD4<sup>+</sup> Effector T Cells Devoid of Immune Checkpoints (2023)

&lt;p&gt;Impact of CD39 or CD73 inhibitor (ARL67156, APCP) on ATP-mediated inhibition of CD73+ or CD73neg CD4+ Teff in the presence of Treg based on the proliferation markers profiles (Cell trace Violet or CFSE)&lt;/p&gt;
Temporal Fluctuations and Poroelasticity Can Generate Chaotic Advection in Natural Groundwater Systems (2019)

Abstract Although steady, isotropic Darcy flows are inherently laminar and nonmixing in the absence of diffusion, it is well understood that transient forcing via engineered pumping schemes can induce rapid, chaotic mixing flows in groundwater. In this study we explore the propensity for such mixing to arise in natural groundwater systems subject to cyclical forcings, for example, tidal or seasonal influences. Using a conventional linear groundwater flow model subject to tidal forcing, we show that under certain conditions these flows generate Lagrangian transport and mixing phenomena (chaotic advection) near the tidal boundary. We show that aquifer heterogeneity, storativity, and forcing magnitude cause reversals in flow direction over the forcing cycle which, in turn, generate coherent Lagrangian structures and chaos. These features significantly augment fluid mixing and transport, leading to anomalous residence time distributions, flow segregation, and the potential for profoundly altered reaction kinetics. We define the dimensionless parameter groups which govern this phenomenon and explore these groups in connection with a set of well‐characterized tidal systems. The potential for Lagrangian chaos to be present near discharge boundaries must be recognized and assessed in field studies.
Facile Synthesis of α‐Substituted Acrylate Esters. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Metal Fluorides Nanoconfined in Carbon Nanopores as Reversible High Capacity Cathodes for Li and Li‐Ion Rechargeable Batteries: FeF2 as an Example (2014)

Adv. Energy Mater. 2015, 5, 1401148 Dr. Marta Sevilla was inadvertently omitted as an author of this article. The byline should read: Wentian Gu, Marta Sevilla, Alexandre Magasinski, Bogdan Zdyrko, and Gleb Yushin* The affiliation for Dr. Sevilla is Instituto Nacional del Carbón (CSIC), P.O. Box 73, 33080 Oviedo, Spain.
Data from First Evidence of Sphingosine 1-Phosphate Lyase Protein Expression and Activity Downregulation in Human Neoplasm: Implication for Resistance to Therapeutics in Prostate Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;This is the first report of sphingosine 1-phosphate lyase (SPL) protein expression and enzymatic activity in human neoplasm. This enzyme drives irreversible degradation of sphingosine 1-phosphate (S1P), a bioactive lipid associated with resistance to therapeutics in various cancers, including prostate adenocarcinoma. In fresh human prostatectomy specimens, a remarkable decrease in SPL enzymatic activity was found in tumor samples, as compared with normal adjacent tissues. A significant relationship between loss of SPL expression and higher Gleason score was confirmed in tissue microarray (TMA) analysis. Moreover, SPL protein expression and activity were inversely correlated with those of sphingosine kinase-1 (SphK1), the enzyme producing S1P. SPL and SphK1 expressions were independently predictive of aggressive cancer on TMA, supporting the relevance of S1P in prostate cancer. In human C4-2B and PC-3 cell lines, silencing SPL enhanced survival after irradiation or chemotherapy by decreasing expression of proteins involved in sensing and repairing DNA damage or apoptosis, respectively. In contrast, enforced expression of SPL sensitized cancer cells to irradiation or docetaxel by tilting the ceramide/S1P balance toward cell death. Interestingly, the S1P degradation products failed to sensitize to chemo- and radiotherapy, supporting the crucial role of ceramide/S1P balance in cancer. Of note, the combination of SPL enforced expression with a SphK1 silencing strategy by further decreasing S1P content made prostate cancer cells even more sensitive to anticancer therapies, suggesting that a dual strategy aimed at stimulating SPL, and inhibiting SphK1 could represent a future approach to sensitize cancer cells to cancer treatments. &lt;i&gt;Mol Cancer Ther; 11(9); 1841–51. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Bioactive Components, Anti-Dengue and Insecticidal Potencies of Ricinodendron Heudelotii (Baill.) Seed Oil (2023)

The health and adverse effects on humans and the eco-system at large, arising via the use of synthetic insecticides and larvicides have posed great concern, thus, a need for safe and non-toxic insecticides and larvicides from natural sources.Plants have been reported to contain substances that could be used for various purposes, ranging from health, industrial and therapeutic uses.One of such plants is Ricinodendron heudelotii.Ricinodendron heudelotii (Baill.)commonly called Njangsa is an oily plant in Nigeria; it is widely used for various purposes ranging from food, medicines and a wide range of commodities for the local population.The plant is not much explored for its potential activities.Some of the activities such as anti-inflammatory, antidiabetic, hepato/nephroprotective potencies of the seed extract have been reported (Salehi et al.,
Immune Subdominant Antigens as Vaccine Candidates against Mycobacterium tuberculosis (2014)

Unlike most pathogens, many of the immunodominant epitopes from Mycobacterium tuberculosis are under purifying selection. This startling finding suggests that M. tuberculosis may gain an evolutionary advantage by focusing the human immune response against selected proteins. Although the implications of this to vaccine development are incompletely understood, it has been suggested that inducing strong Th1 responses against Ags that are only weakly recognized during natural infection may circumvent this evasion strategy and increase vaccine efficacy. To test the hypothesis that subdominant and/or weak M. tuberculosis Ags are viable vaccine candidates and to avoid complications because of differential immunodominance hierarchies in humans and experimental animals, we defined the immunodominance hierarchy of 84 recombinant M. tuberculosis proteins in experimentally infected mice. We then combined a subset of these dominant or subdominant Ags with a Th1 augmenting adjuvant, glucopyranosyl lipid adjuvant in stable emulsion, to assess their immunogenicity in M. tuberculosis-naive animals and protective efficacy as measured by a reduction in lung M. tuberculosis burden of infected animals after prophylactic vaccination. We observed little correlation between immunodominance during primary M. tuberculosis infection and vaccine efficacy, confirming the hypothesis that subdominant and weakly antigenic M. tuberculosis proteins are viable vaccine candidates. Finally, we developed two fusion proteins based on strongly protective subdominant fusion proteins. When paired with the glucopyranosyl lipid adjuvant in stable emulsion, these fusion proteins elicited robust Th1 responses and limited pulmonary M. tuberculosis for at least 6 wk postinfection with a single immunization. These findings expand the potential pool of M. tuberculosis proteins that can be considered as vaccine Ag candidates.
A vehicle-user matching tool to encourage electric mobility (2017)

Electric vehicles (EVs) are recognized to be an effective way to reduce global warming pollution. Therefore, there is an increasing interest and effort in developing new ideas and technology to spread the use of EVs as an alternative to conventional cars. However, the consumers' perception of EVs, especially concerning their limited and not-fully predictable range, is still of low reliability, thus the number of sales is increasing slower than expected. In this paper, a software tool for non-EVs owners is presented, with the aim of profiling the drivers and show which EV alternative, if any, would be suitable for each case. The final goal is to encourage electric mobility against range anxiety. The whole analysis is carried out by using experimental data collected from some users in Milan, Italy.
Hierarchically fractal Co with highly exposed active facets and directed electron-transfer effect (2022)

Hierarchically fractal Co with highly exposed active (002) facets, possessing a higher work function and more moderate hydrogen adsorption free energy, has been synthesized <i>via</i> a template-free self-assembly method for the directed electron-transfer design of HER catalysts. It shows a great improvement in the HER activity in comparison with that of nanostructured Co.
A class of cellular computer architectures to support physical design automation (1984)

http://deepblue.lib.umich.edu/bitstream/2027.42/7379/5/bad1753.0001.001.pdf
Trends in the Development of Oral Anticoagulants (2015)

Anticoagulation remains the therapy of choice for the prevention and treatment of venous and arterial thromboembolic disorders which can cause major organ damage or death. Heparins represent the antithrombotic drugs of choice in short and medium-term prophylaxis and therapy of thromboembolic diseases. Fondaparinux, a synthetic and structural analog of the antithrombin-binding pentasaccharide domain of heparin, has selective anti-Xa activity and longer half-life. However, anticoagulants are poorly absorbed by oral route because of their high molecular weight, hydrophilicity and negative charges. Long-term anticoagulation therapy is problematic because of side effects and frequent monitoring. Formulation approaches are particularly promising.
Manipulating Heat Shock Factor-1 in Xenopus Tadpoles: Neuronal Tissues Are Refractory to Exogenous Expression (2010)

Our finding that the majority of neurons, which have little endogenous HSF1, refused to accept transgene-driven expression of HSF1 or its mutant suggests that HSF1 levels are strictly controlled in neuronal tissue.
K-edge Subtraction Computed Tomography with a Compact Synchrotron X-ray Source (2019)

In clinical diagnosis, X-ray computed tomography (CT) is one of the most important imaging techniques. Yet, this method lacks the ability to differentiate similarly absorbing substances like commonly used iodine contrast agent and calcium which is typically seen in calcifications, kidney stones and bones. K-edge subtraction (KES) imaging can help distinguish these materials by subtracting two CT scans recorded at different X-ray energies. So far, this method mostly relies on monochromatic X-rays produced at large synchrotron facilities. Here, we present the first proof-of-principle experiment of a filter-based KES CT method performed at a compact synchrotron X-ray source based on inverse-Compton scattering, the Munich Compact Light Source (MuCLS). It is shown that iodine contrast agent and calcium can be clearly separated to provide CT volumes only showing one of the two materials. These results demonstrate that KES CT at a compact synchrotron source can become an important tool in pre-clinical research.
High-Resolution Touch Floor System Using Particle Swarm Optimization Neural Network (2013)

A touch floor system, based on force sensitive resistors, capable of identifying user position and motion with high resolution, is proposed in this paper. A particle swarm optimization-based neural network (NN), initialized with the output of a Levenberg–Marquardt-based NN, allows inaccuracy drawbacks of the trilateration method in position estimation due to sensor's nonlinearity to be reduced to one fifth under non-stationary conditions. Furthermore, position-tracking accuracy is improved by a Kalman filter and a motion recognition algorithm is suggested for mimicking computer mouse clicks. Experimental results show non-uniformly sized icons displayed with high-resolution coordinates can be selected on the floor by the participants of diversified weights. This proves the feasibility of a high-resolution touch floor interface scalable for large area, by facilitating digitally mediated human–architecture interactions.
SCANNING PROBE ANALYSIS OF DEFECTS INDUCED BY SLIGHT IRON CONTAMINATION ON THERMALLY OXIDIZED p-TYPE SILICON WAFERS (2003)

In this article, we have demonstrated the investigation of scanning probe microscopy on the defects induced by slight iron contamination on p-type Si wafers with ultrathin thermal oxide layer. Using scanning capacitance microscopy (SCM) associated with atomic force microscopy, it is revealed that iron contamination induces interface traps, which significantly perturb the depletion behavior of the silicon surface. Moreover, experimental results also indicate that iron contamination leads to the lifetime decrease and the density increase of minority carriers in the defect region. From the dC/dV–V profiles, the defect region with the highest density of the interface traps also has the highest density of the deep-level traps. At a proper dc bias, the defect region clearly exhibits an obvious contrast in the SCM images.
Experimental realization of a quantum game on a one-way quantum computer (2007)

We report the first demonstration of a quantum game on an all-optical one-way quantum computer. Following a recent theoretical proposal we implement a quantum version of Prisoner's Dilemma, where the quantum circuit is realized by a 4-qubit box-cluster configuration and the player's local strategies by measurements performed on the physical qubits of the cluster. This demonstration underlines the strength and versatility of the one-way model and we expect that this will trigger further interest in designing quantum protocols and algorithms to be tested in state-of-the-art cluster resources.
Sorafenib: a clinical and pharmacologic review (2010)

Sorafenib is a well-tolerated oral antiangiogenic agent approved for treatment of two angiogenesis-driven cancers. Studies to broaden the clinical indications and increase understanding of the clinical and laboratory biomarkers of response are needed.