gebhart/patrepeval huggingface dataset:
MHz frequencies, kW, 30 cm gap wireless power transfer with low air gap flux density and high efficiency using surface spiral winding coils (2017)

MHz operation is required for kW, sub-meter gap wireless power transfer (WPT) to maintain the electromagnetic field strength in the air gap at a very low, intrinsically safe level. To effectively reduce losses associated with skin and proximity effects, surface spiral winding (SSW) coils have been developed for MHz WPT. However, over multi-kV voltage stress has to be sustained by the power amplifier for kW transmission with the use of SSW coils. A design methodology of an efficient power converter for MHz, kW WPT is developed and introduced, with the implementation of an excitation coil to effectively reduce the voltage stress on the power amplifier. The Class E power amplifier is selected for the design and evaluated on a 1 kW, 30 cm gap, 3.5 MHz WPT test system. Up to 96.7% efficiency is obtained on the power amplifier and an overall 90.6% DC-to-DC efficiency is achieved. Magnetic field strength within the air gap is maintained at a very low, intrinsically safe level.
Three‐Dimensional Footprint Mapping of the Deltoid and Trapezius: Anatomic Pearls for Acromioclavicular Joint Reconstruction (2021)

Subperiosteal elevation of the deltoid off the lateral clavicle starting superiorly, anteriorly, and lastly inferiorly will reduce deltoid muscle injury and improve visibility of the coracoid process during reconstruction. Furthermore, knowledge of the attachments of the deltoid and trapezius to the ACLC may help limit iatrogenic injury to these dynamic stabilizers.
A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells (2014)

These results indicate that small molecule inhibitor A-770041 may function to reverse ABCB1/Pgp-mediated chemotherapy drug resistance. Combination of Src family kinase inhibitor with regular chemotherapy drug could be clinically effective in MDR osteosarcoma.
Multiple-beam interference lithography with electron beam written gratings (2002)

Interference lithography with multiple beams provides two-dimensional periodic patterns in a single exposure step. It is possible to obtain various symmetries and shapes such as sparse hole arrays or dots on a hexagonal grid. However, when the number of interfering beams exceeds three, the intensity pattern depends strongly on the relative phases of the beams. In this article we show that this problem can be overcome with a scheme where transmission diffraction gratings written on a single substrate create the interfering beams possessing the required phase relations. The relative phases of the diffracted beams are controlled by the relative positions of the gratings in the substrate plane. We used electron beam lithography with an interferometrically controlled stage to obtain the required precise placement of the gratings. This method enabled us to produce hexagonal and square arrays of holes where we used three and four beam configurations, respectively. Moreover, we created sparse hole arrays that have hexagonal and square symmetries with six and eight beam interference. The experiments were carried out in the extreme ultraviolet region with synchrotron radiation and with laser light in the visible spectrum. The technique requires spatially coherent light but it is achromatic and it is not sensitive to small errors in the alignment of the incoming beam.
ChemInform Abstract: THE MARKOVNIKOFF HYDROBORATION OF A TRISUBSTITUTED OLEFIN (1982)

Abstract Die Hydroborierung von Akuammicin (I) wird untersucht.
Agarose gel structure using atomic force microscopy: Gel concentration and ionic strength effects (1998)

Agarose gels have been studied by atomic force microscopy (AFM). The experiments were especially designed to work in aqueous conditions, allowing direct observation of the "unperturbed" gel without invasive treatment. AFM images clearly show strong dependence of pore diameter and its distribution on ionic strength of the solvent. As the ionic strength increases, the distribution becomes broader and the position of its maximum shifts toward higher values. The evolution of the distribution curves indicates that gels become more homogeneous with decreasing Tris-borate-EDTA (TBE) buffer concentration. An empirical law of the mean pore diameter as a function of the ionic strength is established. In agreement with our previous work we found that, for a given ionic strength, the pore diameter increases when the agarose concentration decreases and that the wide pore diameter distribution narrows as the gel concentration increases.
Supplementary Table S1 from Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma (2023)

&lt;p&gt;PDF file - 84 KB, Differentially expressed cells in genes upon exposure to 20 muM lovastatin in resistant MM cell lines (LP1).&lt;/p&gt;
Coal Char Derived Few-Layer Graphene Anodes for Lithium Ion Batteries (2014)

Few-layer graphene films were synthesized through chemical vapor deposition technique using coal char as solid carbon source. Raman spectroscopy, X-ray diffraction, transmission electron microscopy, and selected area electron diffraction were used to characterize the graphene films. The electrochemical performance of the coal char derived few layer graphene anodes for lithium ion batteries was investigated by charge/discharge curves and discharge capacity at different current densities. The graphene anode maintained the reversible capacity at ~0.025, 0.013, and 0.007 mAh/cm2 at a current density of 10, 30, and 50 µA/cm2, respectively. The coal char derived graphene anodes show potential applications in thin film batteries for nanoelectronics.
Multiple Post-translational Modifications Affect Heterologous Protein Synthesis (2012)

Post-translational modifications (PTMs) are required for proper folding of many proteins. The low capacity for PTMs hinders the production of heterologous proteins in the widely used prokaryotic systems of protein synthesis. Until now, a systematic and comprehensive study concerning the specific effects of individual PTMs on heterologous protein synthesis has not been presented. To address this issue, we expressed 1488 human proteins and their domains in a bacterial cell-free system, and we examined the correlation of the expression yields with the presence of multiple PTM sites bioinformatically predicted in these proteins. This approach revealed a number of previously unknown statistically significant correlations. Prediction of some PTMs, such as myristoylation, glycosylation, palmitoylation, and disulfide bond formation, was found to significantly worsen protein amenability to soluble expression. The presence of other PTMs, such as aspartyl hydroxylation, C-terminal amidation, and Tyr sulfation, did not correlate with the yield of heterologous protein expression. Surprisingly, the predicted presence of several PTMs, such as phosphorylation, ubiquitination, SUMOylation, and prenylation, was associated with the increased production of properly folded soluble proteins. The plausible rationales for the existence of the observed correlations are presented. Our findings suggest that identification of potential PTMs in polypeptide sequences can be of practical use for predicting expression success and optimizing heterologous protein synthesis. In sum, this study provides the most compelling evidence so far for the role of multiple PTMs in the stability and solubility of heterologously expressed recombinant proteins.
Quantification of Regional Left Ventricular Dyssynchrony by Magnetic Resonance Imaging (2008)

Cardiac resynchronization therapy is an established treatment in patients with symptomatic heart failure and intraventricular conduction delay. Electrical dyssynchrony is typically adopted to represent myocardial activation dyssynchrony, which should be compensated by cardiac resynchronization therapy. One third of the patients, however, does not respond to the therapy. Therefore, imaging modalities aimed at the mechanical dyssynchrony estimation have been recently proposed to improve patient selection criteria. This paper presents a novel fully automated method for regional mechanical left ventricular dyssynchrony quantification in short-axis magnetic resonance imaging. The endocardial movement is described by time-displacement curves with respect to an automatically determined reference point. Different methods are proposed for time-displacement curve analysis aimed at the regional contraction timing estimation. These methods were evaluated in two groups of subjects with (nine patients) and without (six patients) left bundle branch block. The contraction timing standard deviation showed a significant increase for left bundle branch block patients with all the methods. A novel method based on phase spectrum analysis may be however preferred due to a better specificity (99.7%) and sensitivity (99.0%). In conclusion, this method provides a valuable prognostic indicator for heart failure patients with dyssynchronous ventricular contraction and it opens new possibilities for regional timing analysis.
Gold(I) Catalyzes the Intermolecular Hydroamination of Alkynes with Imines and Produces α,α′,N-Triarylbisenamines: Studies on Their Use As Intermediates in Synthesis (2010)

α,α',N-triarylbisenamines have been efficiently formed and isolated for the first time. The synthesis is based on an unprecedented gold(I)-catalyzed double intermolecular hydroamination between N-arylamines and aryl alkynes. This reaction constitutes a new example of the intriguing behavior of gold as catalyst in organic synthesis. The reactivity of these bisenamines for three different reactions, leading to potentially useful intermediates, is also shown. In particular, hindered azabicycles [3.2.0], which present excellent UVA and UVB absorption properties, are obtained by addition of triarylbisenamines to propiolates following an unexpected mechanism.
Supplementary Data from Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning–Assisted Gland Analysis (2023)

Supplementary Data from Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning–Assisted Gland Analysis
Correction of a Memory Management Method for Lock-Free Data Structures (1995)

Memory reuse in link-based lock-free data structures requires special care. Many lock-free algorithms require deleted nodes not to be reused until no active pointers point to them. Also, most lock-free algorithms use the compare and swap atomic primitive, which can suffer from the &amp;quot;ABA problem&amp;quot; [1] associated with memory reuse. Valois [3] proposed a memory management method for link-based data structures that addresses these problems. The method associates a reference count with each node of reusable memory. A node is reused only when no processes or data structures point to it. The method solves the ABA problem for acyclic link-based data structures, and allows lock-free algorithms more flexibility as nodes are not required to be freed immediately after a delete operation (e.g. dequeue, pop, delete min, etc.). However, there are race conditions that may corrupt data structure that use this method. In this report we correct these race conditions and present a corrected version of Valoi...
Abstract 18211: Can Salvage Takedown of Cavopulmonary Connection Act as a Bridge to Subsequent Palliation? (2014)

Objectives: Bidirectional cavopulmonary shunt (BCPS) and Fontan takedown are needed occasionally in failing single-ventricle palliation. We sought to analyze the outcomes of salvage takedown focusing on physiologic tolerance and subsequent clinical outcomes. Methods: Twenty-four patients who underwent BCPS or Fontan takedown procedures from 1986 to 2013 were reviewed. Physiologic tolerance was defined as bridge to subsequent re-BCPS or re-Fontan, transplantation, and palliation suitable for future transplantation. Outcomes were compared using competing risk and Kaplan-Meier analysis. Results: Nine (38%) patients underwent BCPS takedown [8 (89%) after 2000] and 15 (62%) patients underwent Fontan takedown [2 (13%) after 2000]. Nineteen (79%) patients had acute takedown (<1 month). The indications for BCPS takedown included hypoxia (n=7) and superior vena cava syndrome (n=2). Fontan takedown was due to low cardiac output (n=7), high Fontan pressure (n=5), cyanosis (n=1), persistent drainage (n=1), and protei...
Plan de negocios para la creación de una empresa dedicada a la elaboración y comercialización de productos dermatológicos personalizados, en la ciudad de Ambato (2016)

The aim of this study was to analyze and verify the feasibility of creating a company dedicated to the production and merchandising of customize dermatological products in Ambato. For this purpose, it was necessary to develop a research to analyze the industry and market, so it can be possible to build a profitable business model. The industry analysis found those opportunities and threats to which the project would be exposed and it gave an excellent starting point to consolidate a proposal that leads to the needs of the Ecuadorian market. Meanwhile, market research identified several variables that allowed to build the marketing plan. The methods used were exploratory and descriptive, providing key outcomes for the establishment of the value proposition and argument of the marketing mix and services. The tools used were expert interviews, focus groups and surveys. Market research was conclusive and reflected the acceptance of potential customers, to this business proposal. After embracing the possibilities of the business plan, it was necessary to build a marketing plan that could convey the differentiating values from those of competition. This project covers a mix of marketing and services that aims to build a leading brand of its industry. Moreover, as a production venture, the operational plan has attempted to develop an efficient paradigm that guarantees profitability, accomplishes delivery times and allows to offer competitive prices in the market. Finally, a projected financial model was developed, whose purpose was to predict and verify that the project has great prospects of profitability, according to the synergy of the business plan.
Comparative Studies on Monotypic IgMλ and IgGκ from an Individual Patient (1976)

Abstract Amino terminal sequence analyses were performed on the H and L chains of the idiotypically related IgMλ and IgGκ paraproteins isolated from the sera of a patient, Br. The N-terminal 41 residues of the Br κ-chain belonged to the VKIII subgroup, and L chains derived from BrIgMλ revealed a blocked N-terminus characteristic of λ-chains. Comparative sequence analysis of the Br µ- and γ-chains indicated that, although both possessed an unblocked N-terminal glutamic acid, the respective VH regions belonged to separate subgroups. The N-terminal 27 residues of the Br µ-chain reflected a typical VHIII subgroup sequence. The Br γ-chain sequence demonstrated a VHI pattern with an unblocked N-terminus. These structural data stand ir contrast to previously reported serologic evidence, which indicated that the BrIgMλ and BrIgGκ proteins possessed highly similar VH-associated idiotypic determinants. Final interpretation of these findings of similar VH idiotypic determinants expressed by H chains belonging to separate VH subgroups must await complete sequence analysis of the hypervariable segments of the Br γ- and µ-chains.
Holographic Patterning and Crystallization of a Semicrystalline polymer (2006)

Four new dimeric phenolic glycosides (1- 4), a new iridoid diglycoside (5), and 15 known glycosides have been isolated from an ethanolic extract of the bark of Adina polycephala. Their structures were determined by spectroscopic and chemical methods. Compounds 1, 3, and 5 showed in vitro inhibitory activity against the release of beta-glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor.
A Haptic Virtual Environment for Tele-Echography (2002)

Having a haptic virtual environment for tele-echography will enable the medical expert with faster adaptation and especially facilitated immersion in what we could call a "virtual echographic examination cabinet". The innovation of this haptic control is to preserve medical expert proprioception and gesture feelings, which provide the users with indications that are synchronized with the echographic images. In this paper, we will focus on the telegesture module: we will detail several issues and solutions related to this particular problem of tele-robotic scan examination.
Select host cell proteins coelute with monoclonal antibodies in protein a chromatography (2011)

The most significant factor contributing to the presence of host cell protein (HCP) impurities in Protein A chromatography eluates is their association with the product monoclonal antibodies (mAbs) has been reported previously, and it has been suggested that more efficacious column washes may be developed by targeting the disruption of the mAbs-HCP interaction. However, characterization of this interaction is not straight forward as it is likely to involve multiple proteins and/or types of interaction. This work is an attempt to begin to understand the contribution of HCP subpopulations and/or mAb interaction propensity to the variability in HCP levels in the Protein A eluate. We performed a flowthrough (FT) recycling study with product respiking using two antibody molecules of apparently different HCP interaction propensities. In each case, the ELISA assay showed depletion of select subpopulations of HCP in Protein A eluates in subsequent column runs, while the feedstock HCP in the FTs remained unchanged from its native harvested cell culture fluid (HCCF) levels. In a separate study, the final FT from each molecule's recycling study was cross-spiked with various mAbs. In this case, Protein A eluate levels remained low for all but two molecules which were known as having high apparent HCP interaction propensity. The results of these studies suggest that mAbs may preferentially bind to select subsets of HCPs, and the degree of interaction and/or identity of the associated HCPs may vary depending on the mAb.
Weave-pattern-dependent fabric piezoelectric pressure sensors based on polyvinylidene fluoride nanofibers electrospun with 50 nozzles (2022)

Abstract Wearable pressure sensors having versatile device structures have been extensively investigated to achieve high sensitivity under mechanical stimuli. Here, we introduce piezoelectric pressure sensors based on fabrics woven using polyvinylidene fluoride (PVDF) weft and polyethylene terephthalate (PET) warp yarns with different weave structures: 1/1 (plain), 2/2, and 3/3 weft rib patterns. The dependence of the pressure-sensing performance on the weave pattern is demonstrated with an actual large-scale fabric up to the ~2 m scale. An optimized pressure sensor with a 2/2 weft rib pattern produced a high sensitivity of 83 mV N −1 , which was 245% higher than that of the 1/1 pattern. The detection performance of the optimal fabric was extensively evaluated with a variety of ambient input sources, such as pressing, bending, twisting, and crumpling, as well as various human motions. Further, a large all-fabric pressure sensor with arrayed touch pixel units demonstrated highly sensitive and stable sensing performance.
Calorimetric and Rheological Measurements of Three Commercial Thermosetting Prepreg Epoxies (2006)

The cure kinetics of three different thermosetting resins are investigated using differential scanning calorimetry and oscillatory shear rheometry. For the latter, two different types of plates are used, smooth plates and grooved plates; the latter are used to improve sample–plate contact. In addition, oscillatory compression rheology is used; however, machine compliance prevents accurate measurements at high conversions. A fractional conversion is defined based on the maximum storage modulus achieved at a given temperature, and is compared to the fractional conversion calculated from enthalpy measurements. As expected, the rates of reaction derived from these fractional conversions are very different for calorimetry and rheometry. However, the rates of reaction using the two types of plates are identical, although the grooved plates give much more reproducible storage moduli. A number of previously used mathematical expressions are employed to fit the calorimetric and rheological data, and the activation energies calculated from these fits are compared.
Electron Transfer: Insights into Ionic Transport and Structural Changes in Magnetite during Multiple‐Electron Transfer Reactions (Adv. Energy Mater. 10/2016) (2016)

In article number 1502471, Kenneth J. Takeuchi, Feng Wang, and co-workers undertake experimental and theoretical investigations into the local ionic transport and structural evolution in Fe3O4 during (de)lithiation, revealing that the cubic-close-packed O-anion framework was sustained, thereby enabling multi-Li intercalation and conversion reactions. The findings may offer insights into the structure-determined ionic transport and electrochemical reactions in metal oxides, and those of other compounds sharing a ccp anion framework, reminiscent of magnetite.
Injection of Autologous Muscle Stem Cells (Myoblasts) for the Treatment of Vocal Fold Paralysis: A Pilot Study (2007)

Autologous myoblast therapy may be a future treatment for vocal fold paralysis, with current findings demonstrating myoblast survival with attenuation of TA muscle atrophy.
A modular and adaptable analysis pipeline to compare slow cerebral rhythms across heterogeneous datasets (2022)

Neuroscience is moving towards a more integrative discipline, where understanding brain function requires consolidating the accumulated evidence seen across experiments, species, and measurement techniques. A remaining challenge on that path is integrating such heterogeneous data into analysis workflows such that consistent and comparable conclusions can be distilled as an experimental basis for models and theories. Here, we propose a solution in the context of slow wave activity ($&lt;1$ Hz), which occurs during unconscious brain states like sleep and general anesthesia, and is observed across diverse experimental approaches. We address the issue of integrating and comparing heterogeneous data by conceptualizing a general pipeline design that is adaptable to a variety of inputs and applications. Furthermore, we present the Collaborative Brain Wave Analysis Pipeline (Cobrawap) as a concrete, reusable software implementation to perform broad, detailed, and rigorous comparisons of slow wave characteristics across multiple, openly available ECoG and calcium imaging datasets.
ChemInform Abstract: Synthesis, Stereochemistry, and Opioid Receptor Binding Activity of Heterocyclic Analogues of BW373U86. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.