gebhart/patrepeval huggingface dataset:
Performance and calibration of the NIKA camera at the IRAM 30 m telescope (2014)

The New IRAM KID Array (NIKA) instrument is a dual-band imaging camera operating with kinetic inductance detectors (KID) cooled at 100 mK. NIKA is designed to observe the sky at wavelengths of 1.25 and 2.14 mm from the IRAM 30 m telescope at Pico Veleta with an estimated resolution of 13 arcsec and 18 arcsec, respectively. This work presents the performance of the NIKA camera prior to its opening to the astrophysical community as an IRAM common-user facility in early 2014. NIKA is a test bench for the final NIKA2 instrument to be installed at the end of 2015. The last NIKA observation campaigns on November 2012 and June 2013 have been used to evaluate this performance and to improve the control of systematic effects. We discuss here the dynamical tuning of the readout electronics to optimize the KID working point with respect to background changes and the new technique of atmospheric absorption correction. These modifications significantly improve the overall linearity, sensitivity, and absolute calibration performance of NIKA. This is proved on observations of point-like sources for which we obtain a best sensitivity (averaged over all valid detectors) of 40 and 14 mJy s1/2 for optimal weather conditions for the 1.25 and 2.14 mm arrays, respectively. NIKA observations of well known extended sources (DR21 complex and the Horsehead nebula) are presented. This performance makes the NIKA camera a competitive astrophysical instrument.
Design and implementation of an unmanned tail-sitter (2015)

We present the design and implementation of a small Vertical-Take-Off-and-Landing (VTOL) aircraft. The vehicle requires minimal additional components to achieve the hover capability and is thus very efficient in forward flight. We improve over the state of the art by using a single controller in all flight modes without using blending between hover condition and fixed wing controllers or gain scheduling. We present a compact airflow estimation model for VTOL airframes which rely on the slipstream across control surfaces for hover attitude control. Furthermore we show attitude and position control results in simulation. Finally we show outdoor flight experiments validating our simulation results.
Performance of the Dexcom G6 Continuous Glucose Monitoring System During Cardiac Surgery Using Hypothermic Extracorporeal Circulation (2023)

OBJECTIVE Continuous glucose monitoring (CGM) may be challenged by extreme conditions during cardiac surgery using hypothermic extracorporeal circulation (ECC). RESEARCH DESIGN AND METHODS We evaluated the Dexcom G6 sensor in 16 subjects undergoing cardiac surgery with hypothermic ECC, of whom 11 received deep hypothermic circulatory arrest (DHCA). Arterial blood glucose, quantified by the Accu-Chek Inform II meter, served as reference. RESULTS Intrasurgery mean absolute relative difference (MARD) of 256 paired CGM/reference values was 23.8%. MARD was 29.1% during ECC (154 pairs) and 41.6% immediately after DHCA (10 pairs), with a negative bias (signed relative difference: −13.7%, −26.6%, and −41.6%). During surgery, 86.3% pairs were in Clarke error grid zones A or B and 41.0% of sensor readings fulfilled the International Organization for Standardization (ISO) 15197:2013 norm. Postsurgery, MARD was 15.0%. CONCLUSIONS Cardiac surgery using hypothermic ECC challenges the accuracy of the Dexcom G6 CGM although recovery appears to occur thereafter.
Optimal workspace designs of free-floating planar manipulators (2002)

For free-floating manipulators, the workspace of a reference point is a function of the links' geometry, the link masses, and the location of the mass centers. The question addressed is how to choose these parameters, namely, the link lengths, the link masses, and the geometric location of the mass centers such that the workspace is maximized. This question is studied for both free-floating planar open and closed chains in which all the joints are revolute.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The Effect of PPA on Expression of CD2、CD25 and CD69 of Human PBMC (2003)

Objective:To study the effect of PPA (Piliated Pseudomonas aeruginosa strain;PPA) on expression of CD2,CD25 and CD69 of human PBMC. Methods: The techniques of immunocytochemical method and biotin streptavidin (BSA) were applied for evaluation of expression rate of CD2,CD25 and CD69 of human PBMC by PPA stimulation. Results: PPA enhanced significantly CD2,CD25 and CD69 expression as compared with the expression rate in controls. Conclusion: This result indicated that PPA can improve cellular immuno functions.
ChAT (2006)

We present a system for analyzing conversational data. The system includes state-of-the-art natural language processing components that have been modified to accommodate the unique nature of conversational data. In addition, we leverage the added richness of conversational data by analyzing various aspects of the participants and their relationships to each other. Our tool provides users with the ability to easily identify topics or persons of interest, including who talked to whom, when, entities that were discussed, etc. Using this tool, one can also isolate more complex networks of information: individuals who may have discussed the same topics but never talked to each other. The tool includes a UI that plots information over time, and a semantic graph that highlights relationships of interest.
Femtosecond Transient Absorption of Zinc Porphyrins with Oligo(phenylethylnyl) Linkers in Solution and on TiO2 Films (2009)

We measured femtosecond transient absorption of dye solutions and TiO2 films sensitized with two zinc porphyrins (PE1 and PE4) to investigate the interfacial dynamics of electron transfer in relation to the dependence of cell performance on the length of the linker (Lin, C.-Y.; Lo, C.-F.; Luo, L.; Lu, H.-P.; Hung, C.-S.; Diau, E. W.-G. J. Phys. Chem. C 2009, 113, 755−764). For both porphyrins adsorbed on TiO2 films with S1 excitation (λex = 620 nm), the transient absorption kinetics probed at 630 nm and 4.9 μm are complementary to each other because only the excited-state and ground-state species were observed at 630 nm whereas only the charge-separation intermediates were observed at 4.9 μm. The transient of the PE1/TiO2 film shows a single exponential decay with a large offset, whereas the transient of the PE4/TiO2 film displays a biexponential decay with a small offset. Because of the existence of an additional ps component, the amount of free delocalized electrons (offset signal) in PE4/TiO2 is smaller than that in PE1/TiO2. Our results imply that back electron transfer at the TiO2/dye interface is an important factor to be considered to account for the cell performance of a device.
Pseudomonas Aeruginosa Elastase Disrupts the Cortisol-Binding Activity of Corticosteroid-Binding Globulin (2014)

The serine protease inhibitor (SERPIN) family member corticosteroid-binding globulin (CBG) is the main carrier of glucocorticoids in plasma. Human CBG mediates the targeted release of cortisol at sites of inflammation through cleavage of its reactive center loop (RCL) by neutrophil elastase. The RCLs of SERPIN family members are targeted by diverse endogenous and exogenous proteases, including several bacterial proteases. We tested different bacteria for their ability to secrete proteases that disrupt CBG cortisol-binding activity, and characterized the responsible protease and site of CBG cleavage. Serum CBG integrity was assessed by Western blotting and cortisol-binding capacity assay. Effects of time, pH, temperature, and protease inhibitors were tested. Proteolytically active proteins from bacterial media were purified by fast protein liquid chromatography, and the active protease and CBG cleavage sites were identified by mass spectrometry. Among the bacteria tested, medium from Pseudomonas aeruginosa actively disrupted the cortisol-binding activity of CBG. This proteolytic activity was inhibited by zinc chelators and occurred most efficiently at pH 7 and elevated physiological temperature (ie, 41°C). Mass spectrometric analysis of a semi-purified fraction of P. aeruginosa media identified the virulence factor LasB as the responsible protease, and this was confirmed by assaying media from LasB-deficient P. aeruginosa. This metalloprotease cleaves the CBG RCL at a major site, distinct from that targeted by neutrophil elastase. Our results suggest that humoral responses to P. aeruginosa infection are influenced by this pathogen's ability to secrete a protease that promotes the release of the anti-inflammatory steroid, cortisol, from its plasma transport protein.
Specificity of Immobilized Metal Affinity-Based IMAC/C18 Tip Enrichment of Phosphopeptides for Protein Phosphorylation Analysis (2005)

We have developed a simple, highly specific enrichment procedure for phosphopeptides, by increasing the specificity of an immobilized metal affinity column (IMAC) without using any chemical reaction. The method employs a biphasic IMAC-C18 tip, in which IMAC beads are packed on an Empore C18 disk in a 200-microL pipet tip. Phosphopeptides are separated from non-phosphopeptides on the IMAC in an optimized solvent without any chemical reaction, then desorbed from the IMAC using a phosphate buffer, reconcentrated, and desalted on the C18 disk. The increase in selectivity was achieved by (a) using a strong acid to discriminate phosphates from carboxyl groups of peptides and (b) using a high concentration of acetonitrile to remove hydrophobic non-phosphopeptides. The entire procedure was optimized by using known phosphoproteins such as Akt1 kinase and protein kinase A. Although it was difficult to detect phosphopeptides in MALDI-MS spectra of tryptic peptide mixtures before enrichment, after the IMAC procedure, we could successfully detect phosphopeptides with almost no non-phosphopeptides. Next, we constructed an array of IMAC-IMAC/C18 tips, such that number of arrayed tips on a 96-well plate could easily be changed depending on the loading amount of sample. Applying this approach to mouse forebrain resulted in the identification of 162 phosphopeptides (166 phosphorylation sites) from 135 proteins using nano-LC/MS.
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility (2011)

Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P &lt; 5 x 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association across all our datasets (P &lt; 5 x 10(-6) overall, with support in each of the three datasets studied). We also show that polymorphisms of ERAP1, which encodes an endoplasmic reticulum aminopeptidase involved in peptide trimming before HLA class I presentation, only affect ankylosing spondylitis risk in HLA-B27-positive individuals. These findings provide strong evidence that HLA-B27 operates in ankylosing spondylitis through a mechanism involving aberrant processing of antigenic peptides.
Micropatterned Polypyrrole: A Combination of Electrical and Topographical Characteristics for the Stimulation of Cells (2007)

Electrically conducting polymers such as polypyrrole (PPy) are important biomaterials in neural engineering applications, including neural probes, nerve conduits, and scaffolds for tissue and nerve regeneration. Surface modification of these polymers can introduce other valuable characteristics for neural interfacing in addition to electrical conductivity, such as topographical features and chemical bioactivity. Here, the patterning of PPy to create topographical cues for cells is reported. In particular, 1 and 2 µm wide PPy microchannels are fabricated using electron-beam (e-beam) lithography and electropolymerization. A systematic analysis of parameters controlling PPy micropatterning is performed, and finds that microchannel depth, roughness, and morphology are highly dependent on the e-beam writing current, polymerization current, PPy/dopant concentrations, and the polymerization time. Embryonic hippocampal neurons cultured on patterned PPy polarize (i.e., defined an axon) faster on this modified material, with a twofold increase in the number of cells with axons compared to cells cultured on unmodified PPy. These topographical features also have an effect on axon orientation but do not have a significant effect on overall axon length. This is the first investigation that studies controlled PPy patterning with small dimensions (i.e., less than 5 µm) for biological applications, which demonstrates the relevance of expanding microelectronic materials and techniques to the biomedical field.
A Computational Workflow for Flow and Transport in Fractured Porous Media Based on a Hierarchical Nonlinear Discrete Fracture Modeling Approach (2020)

Modeling flow and transport in fractured porous media has been a topic of intensive research for a number of energy- and environment-related industries. The presence of multiscale fractures makes it an extremely challenging task to resolve accurately and efficiently the flow dynamics at both the local and global scales. To tackle this challenge, we developed a computational workflow that adopts a two-level hierarchical strategy based on fracture length partitioning. This was achieved by specifying a partition length to split the discrete fracture network (DFN) into small-scale fractures and large-scale fractures. Flow-based numerical upscaling was then employed to homogenize the small-scale fractures and the porous matrix into an equivalent/effective single medium, whereas the large-scale fractures were modeled explicitly. As the effective medium properties can be fully tensorial, the developed hierarchical framework constructed the discrete systems for the explicit fracture–matrix sub-domains using the nonlinear two-point flux approximation (NTPFA) scheme. This led to a significant reduction of grid orientation effects, thus developing a robust, applicable, and field-relevant framework. To assess the efficacy of the proposed hierarchical workflow, several numerical simulations were carried out to systematically analyze the effects of the homogenized explicit cutoff length scale, as well as the fracture length and orientation distributions. The effect of different boundary conditions, namely, the constant pressure drop boundary condition and the linear pressure boundary condition, for the numerical upscaling on the accuracy of the workflow was investigated. The results show that when the partition length is much larger than the characteristic length of the grid block, and when the DFN has a predominant orientation that is often the case in practical simulations, the workflow employing linear pressure boundary conditions for numerical upscaling give closer results to the full-model reference solutions. Our findings shed new light on the development of meaningful computational frameworks for highly fractured, heterogeneous geological media where fractures are present at multiple scales.
ChemInform Abstract: 1,3,5‐Tris(1,2,3‐thiadiazol‐4‐yl)benzene. A New Core Synthon for Dendrimers (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Table 4 from Genome-wide Methylation Analysis Identifies Genes Specific to Breast Cancer Hormone Receptor Status and Risk of Recurrence (2023)

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3D multi-layer additive manufacturing of a 2.45 GHz RF front end (2015)

Digital additive manufacturing (AM) is emerging as a promising technology for next-generation RF systems. AM processes that combine multiple materials in a single build and can produce volumetric designs are especially interesting for 3D structural electronics. This paper reports on 3D AM fabricated components for a 2.45 GHz RF front end, specifically a circularly-polarized dipole antenna, a miniaturized capacitive-loaded open-loop resonator filter and a switched-line phase shifter. The printing process integrates fused deposition of thermoplastic substrates with micro-dispensing for deposition of conductive traces. These initial results demonstrate the strong potential for fully-printed RF front ends for light weight, low cost, conformal and readily customized applications.
Adaptation for Automated Drift Detection in Electromechanical Machine Monitoring (2022)

Practical machine learning applications for streaming data can involve concept drift (the change in statistical properties of data over time), one-shot or few-shot learning (starting with only one or a few examples for each class), a scarcity of representative training data, and extreme verification latency (only the initial dataset has ground-truth labels). This work presents a framework for organizing signal processing and machine learning techniques to provide adaptive classification and drift detection. Nonintrusive load monitoring (NILM) serves as an ideal case study, as modern sensing solutions provide a wellspring of electromechanical data sources. There is a lack of training datasets that generalize across different load and fault scenarios. Accordingly, training must be accomplished with a limited set of data when deploying a NILM to a new power system. Also, loads can exhibit concept drift over time either due to faults or normal variation. NILM field data is used as an illustrative case study to demonstrate the proposed framework for adaptation and drift tracking.
Development of Energy-Efficient Single-Electron Transistors with Oxide Nanoelectronics (2010)

Abstract : The principal goal of this DARPA Seedling project was to develop an oxide-based single-electron transistor and memory based on complex oxide nanostructures. The challenge was to create a device with ultra-high density and ultra-low power consumption, comparable to fundamental limits (kT/gate operation) for irreversible classical computing. The specific approach involved the development of a new method for controlling the metal-insulator transition at the LaAlO3/SrTiO3 interface. Previously, a sketch-based field-effect transistor ( SketchFET ) had been demonstrated with feature sizes as small as 2 nm. Modifications of this original design were proposed in which a floating gate could be used to control electron flow through a device channel. The sketch-based single-electron transistor was acronym-ready ( SketchSET ) and waiting to be realized. Along the way toward the development of this device were important fundamental materials and device questions concerning the writing mechanism, its compatibility with commercial manufacturing processes, transistor fundamental speed limitations and on/off ratios, the height of energy barriers created by the writing process, the stability of written structures, and novel device building blocks such as asymmetric barriers. A great deal was learned along the way in those areas as well, with support from this project.
Acoustooptic Crossbar Photonic Switch (1993)

Emerging serial optical communication standards such as Fiber Channel require a large optical crossbar (called a “fabric”) that routes signals in a circuit-switching manner with a few μ sec switching time. The switching fabric must be able to transmit multi-gigabit per second optical signals and should be transparent to wavelength division multiplexing (WDM) protocols, and thus cannot be implemented in existing Silicon or Gallium Arsenide technology. The alternative is to use an all-optical switch which can quickly establish physical connections between fibers.
Bericht über die Diskussion (2006)

I. Forum shopping nach der Europäischen Insolvenzverordnung Die Teilnehmer der von Marcus Lutter geleiteten Diskussion stimmten weitgehend darin überein, dass die Europäische Insolvenzverordnung mit ihrem Zuständigkeitskriterium des „Mittelpunktes der hauptsächlichen Interessen“ den Antragstellern breiten Spielraum für forum shopping eröffne. Es wurde darauf hingewiesen, dass auch für ausschließlich in Deutschland tätige Gesellschaften englischen Rechts bereits im Vereinigten Königreich Verfahren eingeleitet worden seien. Zudem sei zu beobachten, dass sich sogar natürliche Personen die sehr viel großzügigeren Möglichkeiten einer Restschuldbefreiung im europäischen Ausland zunutze machten, indem sie etwa für einige Monate nach Frankreich zögen. Hierzu regte Eidenmüller an, für natürliche Personen künftig auf den Wohnsitz abzustellen und bei dessen Verlegung eine Wartefrist vorzusehen, bevor die Zuständigkeit für die Eröffnung eines Hauptinsolvenzverfahrens in den neuen Wohnsitzstaat wechsle.
Plasma glucose distributions in two pacific populations: The bimodality phenomenon. (1983)

The frequency distribution of plasma glucose concentrations in certain populations show two distinct sub-groups, viz. the non-diabetic group and a hyperglycaemic group. The two groups show up as a double peak (bimodality) in the best-fit frequency distributions of log plasma glucose, and the separation or cut-off point where the two curves intersect, gives an indication of the plasma glucose level at which diabetes could be diagnosed. Venous plasma glucose concentrations two hours after a 75 gm oral glucose load were determined in the Micronesian population of Nauru and the urban Polynesian population of Western Samoa, in subjects aged 20 years and over. Both communities exhibit bimodal frequency distributions of plasma glucose in the upper age groups in both sexes. In the younger age groups the frequency distribution of plasma glucose typically follows the usual unimodal Gaussian curve. However, the high prevalence Nauruans show the bimodal form in all groups except the youngest males. The data show that among these two communities, as with the Pimas, the frequency distribution of plasma glucose concentrations can be used to separate the population into normal and hyperglycaemic groups.
A machine learning based computational approach for prediction of cation distribution in spinel crystal (2023)

In this study, a machine learning based computational approach has been developed to investigate the cation distribution in spinel crystals. The computational approach integrates the construction of datasets consisting of the energies calculated from density functional theory, the training of machine learning models to derive the relationship between system energy and structural features, and atomistic Monte Carlo simulations to sample the thermodynamic equilibrium structures of spinel crystals. It is found that the support vector machine model yields excellent performance in energy predictions based on spinel crystal structures. Furthermore, the developed computational approach has been applied to predict the cation distribution in single spinel MgAl2O4 and MgFe2O4 and double spinel MgAl2-aFeaO4. Agreeing with the available experimental data, the computational approach correctly predicts that the equilibrium degree of inversion of MgAl2O4 increases with temperature, whereas the degree of inversion of MgFe2O4 decreases with temperature. Additionally, it is predicted that the equilibrium occupancy of Mg cations at the tetrahedral and octahedral sites in MgAl2-aFeaO4 could be tuned as a function of chemical composition. Therefore, this study presents a reliable computational approach that can be extended to study the variation of cation distribution with processing temperature and chemical composition in a wide range of complex multi-cation spinel oxides with numerous applications.