gebhart/patrepeval huggingface dataset:
System, method, and computer program product for a two-phase queue (2023)

A system, method, and computer program product are provided for accessing a queue. The method includes receiving a first request to reserve a data record entry in a queue, updating a queue state block based on the first request, and returning a response to the request. A second request is received to commit the data record entry and the queue state block is updated based on the second request.
Desynchronisation of neuronal network activity in traumatic brain injury (2008)

Traumatic brain injury (TBI) is the main cause for mortality and long-time disability in young adults. Apart from structural lesions release of neuroactive substances has been considered to cause functional neuronal disturbances. The composition of cerebrospinal fluid (CSF) from patients with TBI is often modified, but the functional impact of this modified CSF is still not fully investigated. We therefor tested the functional impact of physiologic and modified CSF on the electrophysiological parameters of neuronal networks. Cryopreserved embryonic rat cortex neurons were thawed and plated on multielectrode arrays. Spontaneous extracellular network activity was sampled simulataneously from 60 planar microelectrodes.
Label-free detection of missense mutations and methylation differences in the p53 gene using optically diffracting hydrogels (2015)

We have developed a novel approach for DNA detection as well as genetic screening of mutations by uniquely combining DNA-responsive and optically diffracting materials. This approach entails the polymerization of a photonic crystal within a hydrogel network that alters the diffraction of light in response to a target DNA strand. The utility of this approach, which permits label-free sensing, was demonstrated via the detection of a target sequence from the DNA binding domain of the major tumor suppressor protein p53. Using a complementary capture probe strand, we were able to detect down to picomole concentrations of the target p53 sequence. Moreover, we demonstrated that this approach could readily detect a single base pair mutation in the target strand, which corresponds to the hotspot cancer mutation R175H in p53. The sensitivity of detection was increased by lowering the rate of annealing of the target strand and adjusting the solution ionic strength during optical characterization. Changes in ionic strength during characterization impact the melting temperature of the bound target DNA and the Donnan potential between the hydrogel and solution, which influence detection. We further showed that this approach is sensitive to epigenetic changes via the detection of a fully methylated form of the target p53 sequence. Ultimately, this approach represents a new paradigm for DNA detection and specifically genetic screening of p53 as well as other disease markers and nucleotide modifications that alter the properties of DNA (e.g., epigenetic alterations and adducts with chemical carcinogens).
Ring-opening reactions of cyclic allylic ethers by zirconocene complexes of cyclic alkynes (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRing-opening reactions of cyclic allylic ethers by zirconocene complexes of cyclic alkynesGregory D. Cuny and Stephen L. BuchwaldCite this: Organometallics 1991, 10, 1, 363–365Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/om00047a076https://doi.org/10.1021/om00047a076research-articleACS PublicationsRequest reuse permissionsArticle Views271Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Crystallization of (FeO, Fe<sub>2</sub>O<sub>3</sub>)-CaO-SiO<sub>2</sub> Glasses and Magnetic Properties of Their Crystallized Products (1991)

The crystallization process of an Fe2O3 40, CaO⋅SiO2 60wt% glass was investigated as well as magnetic properties of the crystallized products, in order to reveal principles for obtaining ferrimgnetic and bioactive glass-ceramics useful as thermoseeds for hyperthermia of cancer. When the glass was heat-treated up to temperatures 700° to 950°C, magnetite particles were homogeneously precipitated in a CaO⋅SiO2-based glassy and/or crystalline matrix. The diameter and content of the magnetite increased from 6 to 30nm and 10 to 36wt%, respectively, with increasing temperature of the heat treatment from 700° to 950°C. Above 1000°C, a part of the magnetite was converted into hematite (α-Fe2O3). The glass showed maxima in saturation magnetization and coercive force, 32emu/g and 500 Oe, respectively, when heat-treated up to 950°C. The variation of the magnetization with heat treatment temperature could be well quantitatively interpreted in terms of the content of the magnetite, whereas that of the coercive forces could be explained only qualitatively in terms of the particle size of the magnetite. The coercive forces of the magnetite-containing glass-ceramics were much higher than those of the magnetite powders of the corresponding particle sizes which were prepared from aqueous solutions.
Characterization of a Predominant Immunogenic Outer Membrane Protein of Riemerella anatipestifer (2000)

The ompA gene, encoding the 42-kDa major antigenic outer membrane protein OmpA of Riemerella anatipestifer, the etiololgical agent of septicemia anserum exsudativa, was cloned and expressed in Escherichia coli. Recombinant OmpA displayed a molecular mass similar to that predicted from the nucleotide sequence of the ompA gene but lower than that observed in total cell lysates of R. anatipestifer. The ompA gene showed a conserved C-terminal region comprising the OmpA-like domain and a variable N-terminal region. This structure is similar to those of the analogous outer membrane proteins of several gram-negative bacteria. However, OmpA of R. anatipestifer contains six EF-hand calcium-binding domains and two PEST regions, which distinguish it from other outer membrane proteins. The occurrence of these motifs in OmpA suggests a possible role in virulence for this protein. The ompA gene is present in the R. anatipestifer type strain and in all serotype reference strains. However, it exhibits some minor genetic heterogeneity among different serotypes, which seems not to affect the strong antigenic characteristics of the protein. OmpA is a conserved and strong antigenic determinant of R. anatipestifer and hence is suggested to be a valuable protein for the serodetection of R. anatipestifer infections, independent of their serotype.
Liquid Cooling of a Stacked Quad-Core Processor and DRAM Using Laminar Flow in Microchannels (2011)

Three dimensional (3D) stacking of the processor and memory components in high computing applications reduces the communication delay in multicore system-on-a-chip (SoCs) owing to reduced system size and shorter interconnects. The shorter interconnection length between the processing and memory components in a multicore system lowers the overall system access latencies and boosts the system performance. However, this 3D integration of the processors and memory exacerbates the reliability and thermal problems due to high thermal resistance of the stacked designs. Liquid cooling is the most promising solution to overcome this thermal problem arising in the 3D multicore systems. In this paper, we provide a 3D simulation model comprising of quad-core processor, dynamic random-access-memory (DRAM), liquid cooled microchannel heat sink and air-cooled heat sink. The thermal resistance offered by the silicon oxide layer and thermal interface material (TIM) has also been taken into account. The model assumes the integration of the thermal as well as electrical vias and considers the modified thermal conductivity of the materials in the stack. The cores of the quad-core processor are identical, have non-uniform power dissipation and are arranged in a symmetric layout. The quad-core layouts are based on the traditional and optimized floor plan of a single-core microprocessor. The paper reports the results for both planar flow and impingement flow in the microchannels. The thermal efficiency of the 3D design is evaluated on the basis of the hot spot temperature, hot spot spread and number of hot spots on the surface of the chip as well as DRAM.
A New Selective Estrogen Receptor Modulator with Potent Uterine Antagonist Activity, Agonist Activity in Bone, and Minimal Ovarian Stimulation (2005)

The use of selective estrogen receptor modulators for the treatment of estrogen-dependent diseases in premenopausal women has been hindered by undesirable ovarian stimulation and associated risks of ovarian cysts. We have identified a selective estrogen receptor modulator compound (LY2066948) that is a strong estrogen antagonist in the uterus yet has minimal effects on the ovaries of rats. LY2066948 binds with high affinity to both estrogen receptors and has potent estrogen antagonist activity in human uterine and breast cancer cells. Oral administration of LY2066948 to immature rats blocked uterine weight gain induced by ethynyl estradiol with an ED50 of 0.07 mg/kg. Studies in mature rats demonstrated that LY2066948 decreases uterine weight by 51% after 35 d treatment, confirming potent uterine antagonist activity over several estrous cycles. This strong uterine response contrasted with the minimal effects on the ovaries: serum estradiol levels remained within the normal range, whereas histologic evaluation showed granulosa cell hyperplasia in few of the rats. Bone studies demonstrated that LY2066948 prevented ovariectomy-induced bone loss and treatment of ovary-intact rats caused no bone loss, confirming estrogen receptor agonist skeletal effects. Collectively, these data show that LY2066948 exhibits a tissue-specific profile consistent with strong antagonist activity in the uterus, agonist activity in bone, and minimal effects in the ovaries.
Frontispiece: Finding the Most Catalytically Active Platinum Clusters With Low Atomicity (2015)

Cluster Compounds The atomicity of subnanometer platinum clusters significantly influences their catalytic activity. In their Communication on page 9810 ff., K. Yamamoto et al. report Pt19 as the most catalytically active species for oxygen reduction.
Dabrafenib plus trametinib in BRAFV600E-mutated rare cancers: the phase 2 ROAR trial (2023)

BRAFV600E alterations are prevalent across multiple tumors. Here we present final efficacy and safety results of a phase 2 basket trial of dabrafenib (BRAF kinase inhibitor) plus trametinib (MEK inhibitor) in eight cohorts of patients with BRAFV600E-mutated advanced rare cancers: anaplastic thyroid carcinoma (n = 36), biliary tract cancer (n = 43), gastrointestinal stromal tumor (n = 1), adenocarcinoma of the small intestine (n = 3), low-grade glioma (n = 13), high-grade glioma (n = 45), hairy cell leukemia (n = 55) and multiple myeloma (n = 19). The primary endpoint of investigator-assessed overall response rate in these cohorts was 56%, 53%, 0%, 67%, 54%, 33%, 89% and 50%, respectively. Secondary endpoints were median duration of response (DoR), progression-free survival (PFS), overall survival (OS) and safety. Median DoR was 14.4 months, 8.9 months, not reached, 7.7 months, not reached, 31.2 months, not reached and 11.1 months, respectively. Median PFS was 6.7 months, 9.0 months, not reached, not evaluable, 9.5 months, 5.5 months, not evaluable and 6.3 months, respectively. Median OS was 14.5 months, 13.5 months, not reached, 21.8 months, not evaluable, 17.6 months, not evaluable and 33.9 months, respectively. The most frequent (≥20% of patients) treatment-related adverse events were pyrexia (40.8%), fatigue (25.7%), chills (25.7%), nausea (23.8%) and rash (20.4%). The encouraging tumor-agnostic activity of dabrafenib plus trametinib suggests that this could be a promising treatment approach for some patients with BRAFV600E-mutated advanced rare cancers. ClinicalTrials.gov registration: NCT02034110 .
[Screening of multiple endocrine neoplasias type 1. Reflexions of the Study Group on Multiple Endocrine Neoplasias type 1]. (1995)

The "Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1 (GENEM 1)" is a French group involved in a comprehensive multicentre study of Multiple Endocrine Neoplasia type 1 syndrome (NEM 1). The objectives of this group are to define diagnostic and therapeutic protocols and to carry out genetic research on NEM1. The first aim of physicians is to recognize the syndrome and to determine the appropriate screening especially into two circumstances: 1 degree In case of isolated and sporadic glandular disease -i-e-parathyroid glands, endocrine pancreas, antehypophysis, adrenal glands and neuroendocrine tumors? 2 degrees In case of very high probability of NEM 1 syndrome? This paper answers these two questions, based on the analysis of the first 150 cases collected by the GENEM 1.
Mass-transported off-axis refractive GaP microlenses for use in a distortionless optical interconnect system (2000)

An array of aspheric off-axis GaP microlenses fabricated by mass-transport smoothing has been used to eliminate distortion in an optical interconnection system employing a single macroscopic relay lens. System design and experimental results are presented.
Simultaneous analysis of bisphenol A based compounds and other monomers leaching from resin‐based dental materials by UHPLC–MS/MS (2017)

Resin-based dental materials have raised debates concerning their safety and biocompatibility, resulting in a growing necessity of profound knowledge on the quantity of released compounds into the oral cavity. In this context, the aim of this study was to develop a comprehensive and reliable procedure based on liquid chromatography with mass spectrometry for the simultaneous analysis of various leached compounds (including bisphenol A based compounds) in samples from in vitro experiments. Different experiments were performed to determine the optimal analytical parameters, comprising mass spectrometry parameters, chromatographic separation conditions, and sample preparation. Four internal standards were used as follows: deuterated diethyl phthalate and bisphenol A (commercially available), and deuterated analogues of triethylene glycol dimethacrylate and urethane dimethacrylate (custom-made). The optimized method was validated for linearity of the calibration curves and the associated correlation coefficient, lower limit of quantification, higher limit of quantification, and intra- and interassay accuracy and precision. Additionally, the developed liquid chromatography with tandem mass spectrometry method was applied to the analysis of leaching compounds from four resin-based dental materials. The results indicated that this method is suitable for the analysis of different target compounds leaching from dental materials. This method might serve as a valuable basis for quick and accurate quantification of leached compounds from resin-based dental materials in biological samples.
Measurements of the groomed and ungroomed jet angularities in pp collisions at $$ \sqrt{s} $$ = 5.02 TeV (2022)

A bstract The jet angularities are a class of jet substructure observables which characterize the angular and momentum distribution of particles within jets. These observables are sensitive to momentum scales ranging from perturbative hard scatterings to nonperturbative fragmentation into final-state hadrons. We report measurements of several groomed and ungroomed jet angularities in pp collisions at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 5 . 02 TeV with the ALICE detector. Jets are reconstructed using charged particle tracks at midrapidity ( |η| &lt; 0 . 9). The anti- k T algorithm is used with jet resolution parameters R = 0 . 2 and R = 0 . 4 for several transverse momentum $$ {p}_{\mathrm{T}}^{\mathrm{ch}} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mi>p</mml:mi> <mml:mi>T</mml:mi> <mml:mi>ch</mml:mi> </mml:msubsup> </mml:math> jet intervals in the 20–100 GeV/ c range. Using the jet grooming algorithm Soft Drop, the sensitivity to softer, wide-angle processes, as well as the underlying event, can be reduced in a way which is well-controlled in theoretical calculations. We report the ungroomed jet angularities, λ α , and groomed jet angularities, λ α ,g , to investigate the interplay between perturbative and nonperturbative effects at low jet momenta. Various angular exponent parameters α = 1, 1.5, 2, and 3 are used to systematically vary the sensitivity of the observable to collinear and soft radiation. Results are compared to analytical predictions at next-to-leading-logarithmic accuracy, which provide a generally good description of the data in the perturbative regime but exhibit discrepancies in the nonperturbative regime. Moreover, these measurements serve as a baseline for future ones in heavy-ion collisions by providing new insight into the interplay between perturbative and nonperturbative effects in the angular and momentum substructure of jets. They supply crucial guidance on the selection of jet resolution parameter, jet transverse momentum, and angular scaling variable for jet quenching studies.
Path Loss Model for Outdoor-to-Indoor Corridor Up to 40GHz Band in Microcell Environments (2017)

This paper proposed that a path loss model for outdoor-to-indoor corridor is presented to construct next generation mobile communication systems. The proposed model covers the frequency range of millimeter wave bands up to 40GHz and provides three dimensional incident angle characteristics. Analysis of path loss characteristics is conducted by ray tracing. We clarify that the paths reflected multiple times between the external walls of buildings and then diffracted into one of the buildings are dominant. Moreover, we also clarify how the paths affect the path loss dependence on frequency and three dimensional incident angle. Therefore, by taking these dependencies into consideration, the proposed model decreases the root mean square errors of prediction results to within about 2 to 6dB in bands up to 40GHz.
Dynamic color Doppler extended field of view imaging (2002)

A new method for generating dynamic color Doppler extended field of view (EFOV) images is presented. The method derives an ECG waveform from the spatial average of Doppler velocity data from a series of co-planar ultrasonic images acquired by translating the probe in the azimuth direction. Translation and rotation parameters between successive images are estimated using speckle correlation of the B-mode data. The images corresponding to the same phase of the synthetic ECG are then combined using, these, motion parameters to form a color Doppler EFOV image. A series of these color Doppler EFOV images are generated corresponding, to, different cardiac phases. These images are then played back in a continuous loop over the B-mode EFOV image.
Should Prior FIT Results Be Incorporated as an Additional Variable to Estimate Risk of Colorectal Neoplasia? A Prospective Study of 5,813 Screening Colonoscopies (2014)

These findings indicated that subjects with negative FIT findings could be risk stratified similarly as those who had not previously received FIT.
Determinação das constantes elásticas dos corpos anisotrópicos por meio de ensaios de compressão diametral (1981)

Neste trabalho apresentam-se as expressões que permitem determinar as constantes elásticas dos corpos anisotrópicos por meio de ensaios de compressão diametral, sobre provetes de secção circular pertencentes aos planos principais ou, a três planos quaisquer, normais entre si. Apresentam-se também os resultados de ensaios já efectuados sobre provetes de xisto.
Postmastectomy radiotherapy after whole breast reconstruction (2020)

The indications for postmastectomy radiotherapy (PMRT) have broadened with up to 30% of patients being offered chest wall irradiation, although this is dependent on medical center with some persistent controversy. PMRT generally aims to deliver broad coverage of the chest wall, treat the ipsilateral supraclavicular fossa and axillary apex, avoid the heart, and minimize the amount of lung tissue within the therapy field. Schechter and colleagues examined 18 different PMRT plans for patients who had undergone reconstruction prior to radiotherapy. A score was developed and two board certified radiation oncologists specializing in breast radiotherapy reviewed all cases. Advances in reconstruction to improve patient comfort such as gas or air-filled expanders, or pre-pectoral placement can create new challenges for optimal radiotherapy. Non-tissue equivalent, such as air, in a pre-pectoral expander can limit dose build up and compromise the dose planning algorithms and should be avoided in patients who will receive PMRT.
Mode hop free single mode fibre laser with frequency scanning for fibre optic spectroscopy (1999)

We describe the experimental construction of a single longitudinal mode Er-doped fibre ring laser incorporating a ring resonator filter. The system is designed to avoid mode hopping and may be frequency scanned for spectroscopic sensor applications.
In-plane magnetic field dependence of cyclotron relaxation time in a Si two-dimensional electron system (2012)

Cyclotron resonance of two-dimensional electrons is studied for a high-mobility Si/SiGe quantum well in the presence of an in-plane magnetic field, which induces spin polarization. The relaxation time ${\ensuremath{\tau}}_{\mathrm{CR}}$ shows a negative in-plane magnetic-field dependence, which is similar to that of the transport scattering time ${\ensuremath{\tau}}_{t}$ obtained from dc resistivity. The resonance magnetic field shows an unexpected negative shift with increasing in-plane magnetic field.