gebhart/patrepeval huggingface dataset:
Abstract 4037: Doxazosin exerts anti-metastatic potential in triple-negative breast cancer via impairment of cancer stem-like features (2023)

Abstract Background and Purpose: Triple-negative breast cancer (TNBC) tumors typically harbor a high cancer stem-like population leading to chemo-resistance, recurrence, and metastasis. Tumor metastasis is associated with 90% of cancer-related deaths, highlighting the urgent clinical unmet need. Doxazosin is known to inhibit cell migration and invasion in several cancer cell types; however, the precise mechanisms underlying doxazosin’s anticancer effects in TNBC have not been fully elucidated. In the present study, we sought to investigate the mechanism of action of doxazosin responsible for its effects on apoptosis, cancer stem cell (CSC)-like properties, cell migration, and metastasis in TNBC. Experimental designs: Doxazosin on TNBC cell lines [MDA-MB-231, BT549, and 4T1] in vitro was evaluated in cell viability, apoptosis, cell migration, CD44/CD24 staining, ALDH1 activity, and mammosphere formation. The effect of doxazosin on tumor growth, angiogenesis, and metastasis was evaluated in an orthotopic allograft mice model with CSC-enriched population. Results: Doxazosin significantly reduced cell viability and induced apoptosis in MDA-MB-231 and BT549 cells via activation of caspase-3/-7 and cleavage of PARP. Doxazosin significantly suppressed cell migratory capability, concomitant with disrupting cytoskeletal proteins, including vimentin and F-actin expression in TNBC cells. An impairment of BCSC-like properties was associated with reduction of ALDH1 activity and the CD44+/CD24- population, concomitant with suppression of mammosphere-forming ability. Doxazosin administration reduced tumor growth and lung metastasis, as evidenced by a sharp decline in bioluminescence signal intensity. Inhibitory effect of tumor growth was accompanied by a significant decrease of Ki-67 and enhancement of apoptosis with DNA fragmentation and increased cleaved-caspase-3 expression. The latter phenomenon was associated with the impediment of JAK2/STAT3 signaling pathway and CSC-like properties. Furthermore, no toxic effects of doxazosin were found in liver and kidney function in animals. Conclusion: Taken together, our findings highlight doxazosin as a promising candidate for drug repurposing in suppressing metastatic TNBC. Citation Format: Seongjae Kim, Dongmi Ko, Juyeon Seo, Soeun Park, Minsu Park, Kee Dal Nam, Yong koo Kang, So Ra Seock, Jaeyoun Park, Eunhye Oh, Eunsun Jung, Yoon-Jae Kim, Ji Young Kim, Jae Hong Seo. Doxazosin exerts anti-metastatic potential in triple-negative breast cancer via impairment of cancer stem-like features. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4037.
Unravelling humidity-gated, temperature responsive bilayer actuators (2020)

By spraying liquid crystal mixtures onto stretched polyamide 6 (PA6) substrates, dual-responsive heat/humidity bilayer actuators are generated. The oriented PA6 guides the self-organization of the liquid crystal monomers into well-aligned, anisotropic liquid crystal networks. The bilayer responds to changes in the environmental relative humidity, resulting in bending of the actuator with the liquid crystal network inside the curvature. In contrast, in conditions of constant high humidity (80%RH), increasing the temperature triggers the liquid crystal network coating to bend the bilayer in the opposing direction. The dual-responsivity to changes in environmental humidity and temperature is examined in detail and discussed theoretically to elucidate the humidity-gated, temperature responsive properties revealing guidelines for fabricating anisotropic bilayer actuators.
History of noise quality in the automotive industry (1990)

This paper will present a brief look at the emerging philosophy of sound quality as viewed from within the automotive engineering community. A few examples of the concepts of sound quality will be discussed focusing on their relevance to noise control in vehicles. The paper will be primarily historical in content relating how the ideas of sound quality came to be recognized as an important factor in noise control for automobiles.
Endocrine/neuroendocrine glands: Adrenal cortical carcinoma (2011)

Review on Endocrine/neuroendocrine glands: Adrenal cortical carcinoma, with data on clinics, and the genes involved.
S5‐01‐02: C. elegans models of Alzheimer's disease and Parkinson's disease: Systems biology identifies LRRK2 shared interaction networks (2010)

We have used a systems biology approach to understand the biology of LRRK2, which is a gene that is mutated in Parkinson's disease (PD) and associated with pleiotropic pathology that includes α-synuclein or tau inclusions. We generated lines of C. elegans expressing LRRK2 (WT, G2019S or R1441C), and used gene arrays to identify transcriptional changes associated with mitochondrial toxicity (induced by rotenone). Data from these gene arrays was combined with public transcriptome data of patients with PD. The data were analyzed using two systems biology algorithms, context likelihood of relatedness and Mode-of-action by Network Inference, to identify genes possibly interacting with LRRK2. Identified genes (800) were tested by RNA knockdown using a C. elegans line that expresses LRRK2, GFP (in dopaminergic neurons) and made rrf3 RNAi hypersensitivity. Follow-up studies are being done using C. elegans lines lacking lrk-1, the homologue of LRRK2, and in human tissues. One of the striking networks observed was linked to Microtubules and Tau protein, including ptl-1 (tau protein), cdk-5, coel-1 (tubulin folding cofactor E-like, TBCel) and ebp-1 (microtubule end-plus tracking protein, EB1). Knockdown of each protein protected against loss of dopaminergic neurons in C. elegans expressing LRRK2. Given the surprising finding of a systems and RNAi link between tau and LRRK2, we also examined the role of LRRK2 in degeneration induced by tau protein. Knockdown of lrk-1 (the C. elegans homologue of LRRK2) protected against degeneration associated with expression of V337M Tau protein in C. elegans. Conversely, co-expression of LRRK2 (R1441C or G2019S) exacerbated tau-mediated degeneration. Tau is known to be one of the major proteins contributing to degeneration in Alzheimer's disease. Interestingly, GWAS studies of PD consistently rank tau as the second most significant risk factor. However, the relationship between tau and PD is unclear. Our studies raise the possibility that tau might be contributing to the etiology of PD through a mechanism mediated by LRRK2, or vice versa. The identification of other genes known to modify tau function (cdk-5) or microtubule function (coel-1 and ebp-1) supports the putative role of tau in the degenerative pathway.
Vision-only Navigation and Control of Unmanned Aerial Vehicles Using the Sigma-Point Kalman Filter (2007)

This paper presents the vision-only navigation and control of a small autonomous helicopter given only measurements from a video camera fixed on the ground. The goal is to develop an alternative to traditional INS/GPS and on-board vision aided systems. The autonomous navigation and control of the helicopter is achieved using a nonlinear state estimator and a statedependent controller. A key difference to INS/GPS navigation is that measurements of the helicopter’s accelerations and angular velocities are not directly available. The state estimation combines the vision measurements with a dynamic model of the vehicle in a recursive filtering procedure using a Sigma-Point Kalman Filter (SPKF). The estimation of the helicopter’s current state (position, attitude, velocity, and angular velocity) is then fed back in real-time to a state-dependent Riccati equation (SDRE) controller to generate radio control commands to the helicopter. Simulations are provided comparing performance relative to INS/GPS navigation. Experiments also show that an accurate dynamic model of the vehicle is necessary for closed-loop stability. Our results indicate the feasibility of designing a vision-only estimation and control system capable of stabilizing and maneuvering a small unmanned helicopter. Other than simple on-board avionics for low level actuator control, the ground station is responsible for video capture, state-estimation, and state-feedback flight control.
The Xist RNA Gene Evolved in Eutherians by Pseudogenization of a Protein-Coding Gene (2006)

The Xist noncoding RNA is the key initiator of the process of X chromosome inactivation in eutherian mammals, but its precise function and origin remain unknown. Although Xist is well conserved among eutherians, until now, no homolog has been identified in other mammals. We show here that Xist evolved, at least partly, from a protein-coding gene and that the loss of proteincoding function of the proto-Xist coincides with the four flanking protein genes becoming pseudogenes. This event occurred after the divergence between eutherians and marsupials, which suggests that mechanisms of dosage compensation have evolved independently in both lineages.
ChemInform Abstract: In situ Generation of Ruthenium‐Chiral Phosphine Complexes and Their Use in Asymmetric Hydrogenation. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Air spacer for 10nm FinFET CMOS and beyond (2016)

For the first time, we report integration of air spacers with FinFET technology at 10nm node dimensions. The benefit of parasitic capacitance reduction by air spacers has been successfully demonstrated both at transistor level (15–25% reduction in overlap capacitance (C OT )) and at ring oscillator level (10–15% reduction in effective capacitance (Cf)). Key process challenges and device implications of integrating air spacers in FinFET are identified. We propose a partial air spacer scheme, in which air spacers are formed only above fin top and sandwiched by two dielectric liners, as a viable option to adopt air spacers in FinFET technology with minimal risks to yield and reliability.
Uniform versus priority dropping for layered video (1998)

In this paper, we analyze the relative merits of uniform versus priority dropping for the transmission of layered video. We first present our original intuitions about these two approaches, and then investigate the issue more thoroughly through simulations and analysis in which we explicitly model the performance of layered video applications. We compare both their performance characteristics and incentive properties, and find that the performance benefit of priority dropping is smaller than we expected, while uniform dropping has worse incentive properties than we previously believed.
Abstract 255: Mechanical Stretch is Not a Major Cause of Ectopic Activation During Early Stage Regional Ischemia in an Isolated Left-Ventricular Working Heart Model (2018)

Background: Acute regional ischemia is a leading cause of death. Ectopic beats may initiate ventricular arrhythmias in the first hour after coronary occlusion; however, the origin of these beats remains poorly understood. Some studies suggest that abnormal mechanical stretch at the ischemic border zone may contribute to the initiation of ectopy. If mechanical stretch plays a major role in triggering ectopic beats, we therefore expect: I , left ventricular working (LVW) hearts will have higher frequency of post-occlusion ectopic activity than non-beating (NB) hearts; II , in LVW hearts, ectopic beats will arise from ventricular sites undergoing mechanical stretch. Methods and Results: Isolated pig hearts were assigned to NB or LVW groups (8 per group) and prepared for Langendorff or LVW perfusion, respectively. Contraction of NB hearts was suppressed with 10 μM blebbistatin. Acute regional ischemia was induced by LAD occlusion. Using a newly developed optical mapping system, electrical activity and mechanical deformation were simultaneously recorded from 0 to 60 minutes after LAD occlusion. Mechanical stretch (positive strain in 2 principal directions) was observed in the ischemic and border zones of LVW but not NB hearts (Figure, Panel A). There was no significant difference in the number of ectopic events in LVW hearts compared to NB hearts (58±35 vs. 32±36, p=0.17). Of the 45 ectopic events that originated from the LV mapping region in LVW hearts, &lt;20% (6) were from sites that underwent mechanical stretch in the prior cardiac cycle (Figure, Panel B). Conclusion: Mechanical stretch does not play a major role in triggering ectopic beats in early acute regional ischemia in this model.
Dispersion characterization of tapered fibers (2004)

The dispersion curves of tapered fibers at various geometries are characterized by using white-light interferometry. In this presentation, the white-light interference patterns at frequencies near the taper’s second zero-dispersion frequency are measured and discussed in detail. A more convenient formula is proposed to fit the experimental data at these frequencies. As a result, small dispersion values can be calculated more efficiently.
Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity (2020)

We describe the synthesis through visible-light photocatalysis of novel functionalized tetracyclic scaffolds that incorporate a fused azabicyclo[3.2.0]heptan-2-one motif, which are structurally interesting cores with potential in natural product synthesis and drug discovery. The synthetic approach involves an intramolecular [2 + 2] cycloaddition with concomitant dearomatization of the heterocycle via an energy transfer process promoted by an iridium-based photosensitizer, to build a complex molecular architecture with at least three stereogenic centers from relatively simple, achiral precursors. These fused azabicyclo[3.2.0]heptan-2-one-based tetracycles were obtained in high yield (generally >99%) and with excellent diastereoselectivity (>99:1). The late-stage derivatization of a bromine-substituted, tetracyclic indoline derivative with alkyl groups, employing a mild Negishi C-C bond forming protocol as a means of increasing structural diversity, provides additional modularity that will enable the delivery of valuable building blocks for medicinal chemistry. Density functional theory calculations were used to compute the T<sub>1</sub>-S<sub>0</sub> free energy gap of the olefin-tethered precursors and also to predict their reactivities based on triplet state energy transfer and transition state energy feasibility.
An integrated voice codec and echo canceller implemented in a single DSP processor (2005)

A new Linear Predictive Echo Canceller (LPEC) is presented which modifies the classical echo canceller structure to pre-whiten the input signal and hence have better convergence properties in the presence of highly correlated input signals such as speech. This structure is integrated with a 16 KBPS Residual Excited Linear Predictive (RELP) Vocoder [1] to allow significant execution speed savings by sharing common processing modules. The integrated LPEC has been implemented in the Vocoder Demonstration System (VDS-20) using a single TMS32020 processor and will be available at the conference for demonstrations.
ENGLAND TO RIO JANEIRO (2014)

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The Electronic Structures of Square-Planar Metal Complexes. V. Spectral Properties of the Maleonitriledithiolate Complexes of Nickel, Palladium, and Platinum (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Electronic Structures of Square-Planar Metal Complexes. V. Spectral Properties of the Maleonitriledithiolate Complexes of Nickel, Palladium, and PlatinumS. I. Shupack, E. Billig, R. J. H. Clark, Raymond. Williams, and Harry B. GrayCite this: J. Am. Chem. Soc. 1964, 86, 21, 4594–4602Publication Date (Print):November 1, 1964Publication History Published online1 May 2002Published inissue 1 November 1964https://pubs.acs.org/doi/10.1021/ja01075a016https://doi.org/10.1021/ja01075a016research-articleACS PublicationsRequest reuse permissionsArticle Views1247Altmetric-Citations193LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Photorealistic rendering for Augmented Reality: A global illumination and BRDF solution (2010)

This paper presents a solution for the photorealistic rendering of synthetic objects into dynamic real scenes, in Augmented Reality applications. In order to achieve this goal, an Image Based Lighting approach is used, where environment maps with different levels of glossiness are generated for each virtual object in the scene at every frame. Due to this, illumination effects, such as color bleeding and specular reflections, can be simulated for virtual objects in a consistent way. A unifying sampling method for the spherical harmonics transformation pass is also used. It is independent of map format and does not need to apply different weights for each sample. The developed technique is combined with an extended version of Lafortune Spatial BRDF, featuring Fresnel effect and an innovative tangent rotation parameterization. The solution is evaluated in various Augmented Reality case studies, where other features like shadowing and lens effects are also exploited.
Terahertz Conductivity of Lithium Salt-Succinonitrile Plastic Crystals (2013)

The terahertz conductivity of succinonitrile decreases when doped with lithium salts, contrary to their DC behavior. In addition, a lattice phonon mode at 1.1 THz is observed in only the crystalline phase of the undoped succinonitrile.
Intraoperative Monitoring of the Dorsal Sacral Roots (1992)

In 31 children (age, 2-17 years) and 1 adult, individual dorsal root action potentials (DRAPs) from the S1-S3 roots were recorded intraoperatively after electrical stimulation of the dorsal penile or clitoral nerves, in preparation for surgery within the cauda equina. In most patients, pudendal afferent activity was present in S2 and S3 bilaterally; in some, the afferent activity was confined to a single root bilaterally, and in one, to a single root on one side. Dorsal root action potentials of small amplitude were recorded from S1 in 15 patients, although in no patient was S1 the primary carrier of these afferents. No lesion of the roots or rootlets carrying significant afferent activity was created during the rhizotomy, and no dysfunction in micturition resulted. We propose that the neurophysiological identification of roots and rootlets carrying afferent activity from the penile or clitoral nerves allows for rhizotomy of the S2 roots with the least possible risk of postoperative micturition and sexual dysfunction.
Improving Retrieval Efficiency of Person Re-Identification Based on Resnet50 (2020)

In recent years, the issue of person re-identification has become more and more popular, which is an important research subject in the field of computer vision, and many models or methods for different predicaments have been proposed successively. However, there are often differences between theory and practice. As a matter of fact, while collecting a large number of pedestrian images, retrieval efficiency becomes one of the significant evaluation indicators. Therefore, how to maintain high precision and quickly respond to retrieval requirements is a very important issue. This thesis explores many proposed person re-identification methods and improves retrieval time under the premise of maintaining a high precision rate. In this paper, we select Resnet50 as the feature output model, and use not only K-means Clustering to filter out the preliminary candidates but also Hierarchical Comparison to reduce the number of feature comparisons. The final experimental result shows the average retrieval time is improved dramatically with a speed-up ratio closed to 8, whereas the precision loss is under 3%.
Preclinical Profile of Gadoquatrane (2022)

The tetrameric gadoquatrane is a novel, highly effective mGBCA for use in MRI. Gadoquatrane provides favorable physicochemical properties (high relaxivity and stability, negligible protein binding) while showing essentially the same PK profile (fast extracellular distribution, fast elimination via the kidneys in an unchanged form) to established mGBCAs on the market. Overall, gadoquatrane is an excellent candidate for further clinical development.
Compact optical-fiber variable attenuator arrays with polymer-network liquid crystals (2001)

Electrically controlled fiber variable-optical-attenuator arrays with polymer-network liquid crystals are shown to be compact and to have a large attenuation range (30-40 dB) and low residual loss (0.55 dB) at wavelengths from 1.3 to 1.6 mum. Their estimated power consumption is very low (<30 nW/channel), and arrays with more than ten channels can be made. The manufacturing process is simple: Trenches 30-100 mum wide are cut across parallel conductive-layer-coated optical fibers and are filled with a polymer-network liquid crystal. The attenuation properties depend on UV-curing conditions and on trench width.
Ultrastructural localization of coagulation factor V in human platelets (1986)

The distribution and transport in platelets of human coagulation Factor V was investigated by immunofluorescent and immunoelectron microscopy. In resting intact platelets, little surface staining was observed by immunofluorescence. In permeable resting cells, punctate staining similar to that reported for fibrinogen (Fbg), thrombospondin (TSP), fibronectin (Fn), von Willebrand factor (VWF), B-thromboglobulin (BTG), and platelet Factor 4 (PF4) was observed. Double label immunofluorescent staining for Fbg and Factor V demonstrated colocalization, suggesting their presence in the same intracellular structure. Thrombin stimulation induced the appearance of larger (approximately 0.5 mu) immunofluorescent masses of these proteins which exactly colocalized. Thus, at the light level, Factor V and Fbg are localized in the same structure in resting and thrombin-stimulated cells. On the ultrastructural level, an alpha granule localization for Fbg has previously been established. We have extended our immunofluorescent observations regarding the localization of Factor V in human platelets by use of transmission electron microscopy of antibody-stained ultrathin frozen sections. In resting cells, staining of virtually all alpha granules was observed for Factor V. In contrast, consistent staining was absent from other organelles including plasma membranes, mitochondria, and vacuolar structures which may represent the open canalicular system. These data thus establish at the ultrastructural level an alpha granule localization of human coagulation Factor V.