gebhart/patrepeval huggingface dataset:
Efficient Two-Round OT Extension and Silent Non-Interactive Secure Computation (2019)

We consider the problem of securely generating useful instances of two-party correlations, such as many independent copies of a random oblivious transfer (OT) correlation, using a small amount of communication. This problem is motivated by the goal of secure computation with silent preprocessing, where a low-communication input-independent setup, followed by local ("silent") computation, enables a lightweight "non-cryptographic" online phase once the inputs are known. Recent works of Boyle et al. (CCS 2018, Crypto 2019) achieve this goal with good concrete efficiency for useful kinds of two-party correlations, including OT correlations, under different variants of the Learning Parity with Noise (LPN) assumption, and using a small number of "base'' oblivious transfers. The protocols of Boyle et al. have several limitations. First, they require a large number of communication rounds. Second, they are only secure against semi-honest parties. Finally, their concrete efficiency estimates are not backed by an actual implementation. In this work we address these limitations, making three main contributions: Eliminating interaction. Under the same assumption, we obtain the first concretely efficient 2-round protocols for generating useful correlations, including OT correlations, in the semi-honest security model. This implies the first efficient 2-round OT extension protocol of any kind and, more generally, protocols for non-interactive secure computation (NISC) that are concretely efficient and have the silent preprocessing feature. Malicious security. We provide security against malicious parties without additional interaction and with only a modest overhead; prior to our work, no similar protocols were known with any number of rounds. Implementation. Finally, we implemented, optimized, and benchmarked our 2-round OT extension protocol, demonstrating that it offers a more attractive alternative to the OT extension protocol of Ishai et al. (Crypto 2003) in many realistic settings.
Structural and dielectric properties of Ba0.5Sr0.5TiO3 thin films grown on Si by off-axis sputtering (1995)

Abstract Polycrystalline and epitaxial Ba0.5Sr0.5TiO3 thin films were grown on Si by 90° off-axis sputtering for potential charge storage applications. Polycrystalline BST films deposited on Pt/Ta coated Si have demonstrated a dielectric constant as high as 600, and a loss tangent as low as 0.01 under optimized growth conditions. Epitaxial Ba0.5Sr0.5TiO3 (110) was achieved by depositions on metallic SrRuO3 (110) electrode, which was epitaxially grown on YSZ (100) buffered Si. The epitaxial heterostructure showed a high degree of crystallinity with little interdiffusion near the interfaces. The measured dielectric constant is about 360, and the leakage current density is lower than 4x10−7 A/cm2 at 1 V. A strong frequency dependence on dielectric constant and loss tangent is observed in 1–10 MHz frequency range for both types of film. This is attributed to the effect of a series resistance in the measurement loop. We show that roll-off frequency depends on both the magnitude of the capacitance and the resistivity of the bottom electrode.
Theoretical study of spur-free dynamic range of a semiconductor resonant cavity linear interferometric intensity modulator (2011)

Simulation results of the performance of a semiconductor resonant cavity linear interferometric intensity modulator are presented. Starting from the rate equations of an injection locked semiconductor laser, the phase response and stable locking range of the injection locked semiconductor laser were obtained. Within the stable locking range without any approximation on the injection power level, effects of the alpha parameter or linewidth enhancement factor of the injection locked semiconductor slave laser, injection ratio, refractive index, and the residual amplitude modulation on the spur-free dynamic range (SFDR) of the modulator are studied.
Optimisation topologique par distribution de matière du design d'une micropompe à ferrofluide sans contrainte de structure fixe (2009)

Les outils d’optimisation topologique par distribution de matiere offrent la possibilite de creer des dispositifs complets independamment du savoir-faire du concepteur. Ce papier presente les resultats d’une application d’un de ces outils a l’etude d’une micropompe a ferrofluide. Presentant initialement l’outil et le probleme a etudier, il se concentre sur la diminution de contrainte liee a l’utilisateur et se termine par la presentation et la discussion des resultats obtenus. Ces contraintes sont autant de limite que l’outil ne peut franchir, se limitant ainsi a une plus faible region accessible du domaine de solutions. Les resultats obtenus apres liberation des contraintes montrent une amelioration des performances en generale sur le cas applique de la micropompe.
Real-Time Patch-Based Stylization of Portraits Using Generative Adversarial Network (2019)

We present a learning-based style transfer algorithm for human portraits which significantly outperforms current state-of-the-art in computational overhead while still maintaining comparable visual quality. We show how to design a conditional generative adversarial network capable to reproduce the output of Fišer et al.'s patch-based method [FJS*17] that is slow to compute but can deliver state-of-the-art visual quality. Since the resulting end-to-end network can be evaluated quickly on current consumer GPUs, our solution enables first real-time high-quality style transfer to facial videos that runs at interactive frame rates. Moreover, in cases when the original algorithmic approach of Fišer et al. fails our network can provide a more visually pleasing result thanks to generalization. We demonstrate the practical utility of our approach on a variety of different styles and target subjects.
Fabrication of photoresist-based polymer resonator antennas using ultra-thick SU-8 based dry films (2013)

The purpose of this paper is to demonstrate fabrication of various photoresist-based polymer resonator antenna structures using ultra-thick SU-8 based dry films. First, a set of dielectric resonator antenna geometries with modified shapes was designed and included in an X-ray mask. Then the ultra-thick dry films were exposed through this mask to construct antennas. 2 mm tall structures with fine features down to 50 μm are achieved. The preliminary results show the existence of new modes in modified shapes which can be utilized for future antenna applications. Over 90% optically transparency makes these SU-8 based structures highly attractive for transparent antenna applications.
Deformability-based sorting of red blood cells in deterministic lateral displacement devices (2016)

Mesoscopic simulations with two-dimensional (2D) models have been performed to elucidate the dynamics of deformable red blood cells (RBCs) in deterministic lateral displacement (DLD) devices. Several shapes of posts, including circular, diamond, square and triangular structures and RBCs with different rigidities are considered. In comparison to rigid particles, the deformable RBCs exhibit much more complex dynamics within a DLD device, which not only brings additional complications but also provides new separation mechanisms (e.g., based on cell deformability). Further simulation results reveal that the post geometry which induces more cell deformation can be applied to effectively sort RBCs based on their rigidity.
CPE run-to-run overlay control for High Volume Manufacturing (2015)

With the introduction of Nix process nodes, leading-edge factories are facing challenging demands in shrinking design margins. Previously uncorrected high-order signatures, and uncompensated temporal changes of high-order signatures, carry an important potential for improvement of on-product overlay (OPO). Until recently, static corrections per exposure (CPE), applied separately from the main APC correction, have been the industry's standard for critical layers [1], [2]. This static correction is setup once per device and layer and then updated periodically or when a machine change point generates a new overlay signature. This is a non-ideal setup for two reasons. First, any drift or sudden shift in tool signature between two CPE update periods can cause worse OPO and a higher rework rate, or, even worse, lead to yield loss at end of line. Second, these corrections are made from full map measurements that can be in excess of 1,000 measurements per wafer [3]. Advanced overlay control algorithms utilizing Run-to-Run (R2R) CPE can be used to reduce the overlay signatures on product in High Volume Manufacturing (HVM) environments. In this paper, we demonstrate the results of a R2R CPE control scheme in HVM. The authors show an improvement up to 20% OPO Mean+3Sigma values on several critical immersion layers at the 28nm and 14 nm technology nodes, and a reduction of out-of-spec residual points per wafer (validated on full map). These results are attained by closely tracking process tool signature changes by means of APC, and with an affordable metrology load which is significantly smaller than full wafer measurements.
IDEA, a CAD Tool for the Design of Deformable Micro-Structures: Extension to the 2D Deformation of Arbitrarily-Shaped Membranes (2005)

This paper deals with the extension of a software tool aimed at the design of deformable MEMS structures, from the 1D (axisymmetric) case to the 2D case. This tool is based on an inverse formulation of the nonlinear design problem, which leads to very short computing times compared to classical approaches. In the present paper, we focus on the mechanical part of the inverse problem and validate our approach by comparing with finite element simulations, in the case of a deformable micro-mirror.
Fault Diagnostics Using Network Motif Signature (2012)

&#x0D; &#x0D; &#x0D; In modern vehicles, controls are distributed over multiple Electronic Control Units (ECUs) that are connected through in-vehicle communication networks. Fault diagnostics for such a distributed control system is very challenging, which has resulted in many no-trouble-found (NTF) cases during warranty repairs. To address this problem, we propose a novel network-theoretic approach that detects, identifies, and localizes faults using both the structure of the communication network (topological information) and message flow information. The proposed method not only enables the characterization of normal operation and a-priori known faults across communication networks, which is already beyond the current practice of individual ECU centric diagnostics, but also the diagnostics of unknown or cascading failures emerging from unexpected operational environments.&#x0D; &#x0D; &#x0D;
Initial heart rate score predicts new-onset atrial tachyarrhythmias in pacemaker patients (2023)

Heart rate score independently predicts any subsequent duration of ATAs in pacemaker patients.
Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk (2010)

Existing anticoagulants effectively inhibit the activity of coagulation factors of the extrinsic and common pathway but have substantial limitations and can cause severe bleeding complications. Here we describe a novel therapeutic approach to thrombosis treatment. We have developed and characterized the efficacy and safety of selective second-generation antisense oligonucleotides (ASOs) targeting coagulation factor XI (FXI), a member of the intrinsic coagulation pathway. Systemic treatment of mice with FXI ASO led to a potent, specific, and dose-dependent reduction of FXI mRNA levels in the liver with corresponding reductions in plasma levels of FXI protein and activity. FXIASO treatment produced potent, dose-dependent antithrombotic activity in various venous and arterial thrombosis models, comparable with warfarin or enoxaparin. However, unlike warfarin or enoxaparin, FXI inhibition did not cause bleeding. Coadministration of FXI ASO with enoxaparin or the antiplatelet drug clopidogrel produced improved antithrombotic activity without increased bleeding. Finally, plasma-derived FXI concentrate was shown to effectively and rapidly reverse the anticoagulant effect of FXI antisense therapy. These results support the concept that inhibition of FXI through antisense therapy might serve as a new and effective strategy for the treatment and prevention of venous thromboembolism with improved specificity and safety.
O1‐03‐03: HUMAN IN VIVO TAU PATHOLOGY, IMPAIRED NREM SLEEP OSCILLATIONS AND MEMORY DECLINE IN AGING (2018)

Aging disrupts sleep. Moreover, these sleep impairments are exaggerated in Alzheimer's disease, and are proposed to contribute to cognitive decline. Recent human studies have linked β-amyloid with non-rapid eye-movement (NREM) sleep disruption. However, the impact of tau pathology on human sleep oscillations and cognition remains uninvestigated. Here, we tested the hypothesis that tau burden within medial temporal lobe (MTL) impairs the coupled relationship between the two key NREM sleep oscillations—sleep spindles and slow waves, and their known support of hippocampal memory. In vivo tau was measured with [18F]AV1451 PET in cognitively normal older adults (n=19, mean age=75.8), together with overnight, dense-array sleep EEG recordings. A validated associative recognition task was used to measure hippocampal memory function. Analyses focused on relationships between three measurements: (i) AV1451 tau PET binding in MTL measured as the mean (L+R) standardized uptake value ratio of tracer relative to inferior cerebellar gray matter (SUVR), (ii) EEG phase-amplitude coupling between NREM spindles and slow wave oscillations, and (iii) hippocampus-dependent memory. Worse memory performance was related to greater tau burden in MTL (AV1451 SUVR; p=0.03; Fig. 1). MTL tau burden additionally predicted the severity of impaired sleep spindle-slow wave oscillation coupling over the prefrontal cortex (p=0.03; Fig. 2, top). Moreover, this tau-related sleep disruption of spindle-slow wave coupling predicted the degree of memory impairment (p=0.05; Fig. 2, bottom).
Distributed camera network localization (2005)

Localization, estimating the positions and orientations of a set of cameras, is a critical first step in camera-based sensor network applications such as geometric estimation, scene reconstruction, and motion tracking. We propose a new distributed localization algorithm for networks of cameras with sparse overlapping view structure that is energy efficient and copes well with networking dynamics. The distributed nature of the localization computations can result in order-of-magnitude savings in communication energy over centralized approaches.
Effects of long-term proBNP cardiac gene delivery in experimental hypertensive heart disease (2011)

Results In SHR, a single systemic administration of AAV9 vector allowed longterm, cardiac BNP overexpression with an increase in plasma BNP levels as compared with untreated SHR (433.3±17 vs 60.6±15* pg/ml). This further resulted in reductions in systolic (121±11 vs 184 ±13* mm Hg) and diastolic (103±5 vs 148±24* mm Hg) BP for nine months after injection as compared with untreated SHR. Left ventricular (LV) thickness (1.87±0.1 vs 2.16±0.3* mm), LV end-systolic dimensions (3.96±0.3 vs 4.66±0.6* mm) and LV mass (0.4±0.01 vs 0.49±0.01* gr) were reduced, while ejection fraction was increased (83±2 vs 74±4* %) in BNP-treated compared to untreated SHR. Circumferential systolic strain (-5.04±0.4 vs -3.74 ±0.4* %) and strain rate of the early phase of diastole (-4.57±2.1 vs -2.41±1.3 1/s) were improved in BNP-treated compared with controls. Importantly, the improvement in cardiac function and structure also resulted in a significant increase in survival (p<0.001 vs untreated SHR). Non-cardiac overexpression of BNP, via AAV2 vector, was not associated with changes in plasma BNP and BP in SHR. Nevertheless, normotensive Wistar rats injected with AAV9 proBNP vector showed significantly reduced heart/body weights (0.31± 0.1 vs 3.9±0.1* %) four weeks after injection without BP reduction compared to untreated rats.
Field-of-view/resolution tradeoffs in virtual reality (1992)

Many commercially available virtual-reality systems use LCD-based displays comprising fewer than 10 5 pixels. When these displays are magnified to produce an 80° by 60° image, each pixel subtends about 13 arcmin at the retina. This pixel spacing is approximately equivalent to a visual acuity of 20/200, which limits task performance in some applications. We have examined task performance in low-resolution virtual worlds consisting of target objects and distractors viewed through virtual apertures. Target objects could be positioned at a fixed distance from the viewer, at any azimuth and at any elevation within 45° of horizontal. Virtual apertures of various sizes constrained the viewer's field of view. The chromaticity and luminance of backgrounds surrounding the virtual apertures could be varied. We will report the effects of aperture size, background visibility, and distractor type on target detection in low-resolution virtual worlds.
Synthesis of Uniform GaN Quantum Dot Arrays via Electron Nanolithography of D2GaN3 (2004)

Extended abstract of a paper presented at Microscopy and Microanalysis 2004 in Savannah, Georgia, USA, August 1–5, 2004.
Kinetic Study of Free-Radical Solution Copoly- merization ofN-Acryloylmorpholine with an Activated Ester-Type Monomer,N-Acryloxysuccinimide (2001)

The kinetics of free radical solution (co)polymerization of N-acryloylmorpholine (NAM) and N-acryloxysuccinimide (NAS) have been investigated at 60°C in 1,4-dioxane using 2,2′-azoisobutyronitrile as the initiator. First, the kp/kt1/2 value for the homopolymerization of NAM monomer was estimated to be 4.97 mol–1/2·L1/2· s–1/2, which is indicative of a high ability of NAM to homopolymerize. Then, the reactivity ratios were determined to be rNAS = 0.63 ± 0.03 and rNAM = 0.75 ± 0.01. This binary comonomer system behaves like a perfectly random one, allowing the synthesis of macromolecules homogeneous in composition. Average copolymer compositions determined by 1H NMR and 13C NMR spectroscopy were in good agreement with the theoretical ones. Finally, monomer sequence distribution was studied by 13C NMR analysis.
Protection of Myocytes From Hypoxia-Reoxygenation Injury by Nitric Oxide Is Mediated by Modulation of Transforming Growth Factor-β 1 (2002)

These observations suggest modulation of TGF-beta1 expression as a novel mechanism of salutary effect of NO donors. PKC-alpha activation may play an important role in the protective effect of NO against H-R injury.
Inverted Ion Current Rectification-Based Chemical Delivery Probes for Stimulation of Neurons (2021)

Ion current rectification (ICR), diodelike behavior in surface-charged nanopores, shows promise in the design of delivery probes for manipulation of neural networks as it can solve diffusive leakages that might be critical in clinical and research applications. However, it has not been achieved because ICR has restrictions in nanosized dimension and low electrolyte concentration, and rectification direction is inappropriate for delivery. Herein, we present a polyelectrolyte gel-filled (PGF) micropipette harnessing inverted ICR as a delivery probe, which quantitatively transports glutamate to stimulate primary cultured neurons with high efficiency while minimizing leakages. Since the gel works as an ensemble of numerous surface-charged nanopores, the current is rectified in the micro-opening and physiological environment. By extending the charge-selective region using the gel, inverted ICR is generated, which drives outward deliveries of major charge carriers. This study will help in exploring new aspects of ICR and broaden its applications for advanced chemical delivery.
FLUIDOT: A Modular Microfluidic Platform for Single‐Cell Study and Retrieval, with Applications in Drug Tolerance Screening and Antibody Mining (2023)

Advancements in lab-on-a-chip technologies have revolutionized the single-cell analysis field. However, an accessible platform for in-depth screening and specific retrieval of single cells, which moreover enables studying diverse cell types and performing various downstream analyses, is still lacking. As a solution, FLUIDOT is introduced, a versatile microfluidic platform incorporating customizable microwells, optical tweezers and an interchangeable cell-retrieval system. Thanks to its smart microfluidic design, FLUIDOT is straightforward to fabricate and operate, rendering the technology widely accessible. The performance of FLUIDOT is validated and its versatility is subsequently demonstrated in two applications. First, drug tolerance in yeast cells is studied, resulting in the discovery of two treatment-tolerant populations. Second, B cells from convalescent COVID-19 patients are screened, leading to the discovery of highly affine, in vitro neutralizing monoclonal antibodies against SARS-CoV-2. Owing to its performance, flexibility, and accessibility, it is foreseen that FLUIDOT will enable phenotypic and genotypic analysis of diverse cell samples and thus elucidate unexplored biological questions.
Plasma IL-6 changes correlate to PD-1 inhibitor responses in NSCLC (2020)

This study suggests the presence of a systemic, proteomic reflection of successful ICB outside the tumor microenvironment with plasma decreases in IL-6 and CRP.
Parsing the role of NSP1 in SARS-CoV-2 infection (2022)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing coronavirus disease 19 (COVID-19) pandemic. Despite its urgency, we still do not fully understand the molecular basis of SARS-CoV-2 pathogenesis and its ability to antagonize innate immune responses. SARS-CoV-2 leads to shutoff of cellular protein synthesis and over-expression of nsp1, a central shutoff factor in coronaviruses, inhibits cellular gene translation. However, the diverse molecular mechanisms nsp1 employs as well as its functional importance in infection are still unresolved. By overexpressing various nsp1 mutants and generating a SARS-CoV-2 mutant in which nsp1 does not bind ribosomes, we untangle the effects of nsp1. We uncover that nsp1, through inhibition of translation and induction of mRNA degradation, is the main driver of host shutoff during SARS-CoV-2 infection. Furthermore, we find the propagation of nsp1 mutant virus is inhibited specifically in cells with intact interferon (IFN) response as well as <i>in-vivo</i> , in infected hamsters, and this attenuation is associated with stronger induction of type I IFN response. This illustrates that nsp1 shutoff activity has an essential role mainly in counteracting the IFN response. Overall, our results reveal the multifaceted approach nsp1 uses to shut off cellular protein synthesis and uncover the central role it plays in SARS-CoV-2 pathogenesis, explicitly through blockage of the IFN response.