gebhart/patrepeval huggingface dataset:
Inhibition of Influenza A Virus Infection in Vitro by Saliphenylhalamide-Loaded Porous Silicon Nanoparticles (2013)

Influenza A viruses (IAVs) cause recurrent epidemics in humans, with serious threat of lethal worldwide pandemics. The occurrence of antiviral-resistant virus strains and the emergence of highly pathogenic influenza viruses have triggered an urgent need to develop new anti-IAV treatments. One compound found to inhibit IAV, and other virus infections, is saliphenylhalamide (SaliPhe). SaliPhe targets host vacuolar-ATPase and inhibits acidification of endosomes, a process needed for productive virus infection. The major obstacle for the further development of SaliPhe as antiviral drug has been its poor solubility. Here, we investigated the possibility to increase SaliPhe solubility by loading the compound in thermally hydrocarbonized porous silicon (THCPSi) nanoparticles. SaliPhe-loaded nanoparticles were further investigated for the ability to inhibit influenza A infection in human retinal pigment epithelium and Madin-Darby canine kidney cells, and we show that upon release from THCPSi, SaliPhe inhibited IAV infection in vitro and reduced the amount of progeny virus in IAV-infected cells. Overall, the PSi-based nanosystem exhibited increased dissolution of the investigated anti-IAV drug SaliPhe and displayed excellent in vitro stability, low cytotoxicity, and remarkable reduction of viral load in the absence of organic solvents. This proof-of-principle study indicates that PSi nanoparticles could be used for efficient delivery of antivirals to infected cells.
Proxy Mobile IPv6 (PMIPv6) Localized Routing Problem Statement (2011)

Proxy Mobile IPv6 is the IETF Standard for network-based mobility management.In Proxy Mobile IPv6, mobile nodes are topologically anchored at a Local Mobility Anchor, which forwards all data for registered mobile nodes.The setup and maintenance of localized routing, which allows forwarding of data packets between two mobile nodes' Mobility Access Gateways without involvement of their Local Mobility Anchor in forwarding, is not considered.This document describes the problem space of localized routing in Proxy Mobile IPv6.
A Framework for Co-Channel Interference and Collision Probability Tradeoff in LTE Licensed-Assisted Access Networks (2016)

Small cell deployment in heterogeneous networks, whereby small cell base stations (SBS) are deployed alongside traditional macro-cell base stations, is a proven solution for enhancing spatial frequency reuse across licensed spectrum in long-term evolution (LTE) networks. In order to mitigate the shortage of licensed spectrum resources, licensed-assisted access (LAA) has been introduced to allow LTE SBSs to share the unlicensed channel with WiFi nodes. As such, a complex yet interesting optimization problem results from the joint utilization of licensed and unlicensed spectrum resources by the SBSs to meet the quality-of-service (QoS) requirements of small cell users (SUEs). In this paper, we highlight the fundamental tradeoff induced by the SBSs between the amount of co-channel interference (CI) resulting from the reuse of licensed spectrum resources and the collision probability (CP) imposed on the co-existing WiFi nodes due to the sharing of unlicensed spectrum resources in such a coexisting LTE LAA-WiFi heterogeneous network deployment. We find that this fundamental tradeoff can be analyzed by developing a power allocation rule with double water-filling lines and the complete set of Pareto optimal solution can be achieved by the weighted Tchebycheff method. Our simulation results show that the proposed joint resource allocation algorithm can achieve a flexible and suitable tradeoff between the licensed spectrum CI and the WiFi CP according to the QoS requirements of SUEs in LTE LAA networks.
ChemInform Abstract: Synthesis of 3,3‐Diindolyl Oxyindoles Efficiently Catalyzed by FeCl3 and Their in vitro Evaluation for Anticancer Activity. (2010)

Abstract Compound (IIIb) exhibits potent cytotoxicity against SK‐N‐SH and DU‐145 human cancer cell lines, whereas compounds (IIIc)—(IIIe) and (Vc) exhibit potent cytotoxicity against the DU‐145 cell line.
Cloning of human purine-nucleoside phosphorylase cDNA sequences by complementation in Escherichia coli. (1983)

We have obtained cDNA clones that contain the entire coding region of the human purine-nucleoside phosphorylase (PNP; EC 2.4.2.1) mRNA. The cDNA sequences were generated by reverse transcription of PNP-enriched mRNA obtained by immunoadsorption of HeLa cell polyribosomes with monospecific antibody to human PNP. cDNA molecules that were close in length to PNP mRNA were separated by agarose gel electrophoresis and inserted into the Pst I site of the plasmid pBR322. Plasmid DNA from the pooled clones was used to transform PNP-deficient Escherichia coli cells, and those transformants that phenotypically expressed PNP were isolated on selective media. The presence of human PNP in the selected bacterial cells was detected by immunoprecipitation with human PNP antibody.
Natural antibodies sustain differentiation and maturation of human dendritic cells (2004)

The differentiation and maturation of dendritic cells (DCs) is governed by various signals in the microenvironment. Monocytes and DCs circulate in peripheral blood, which contains high levels of natural antibodies (NAbs). NAbs are germ-line-encoded and occur in the absence of deliberate immunization or microbial aggression. To assess the importance of NAbs in the milieu on DC development, we examined the status of DCs in patients with X-linked agammaglobulinemia, a disease characterized by paucity of B cells and circulating antibodies. We demonstrate that the in vitro differentiation of DCs is severely impaired in these patients, at least in part because of low levels of circulating NAbs. We identified NAbs reactive with the CD40 molecule as an important component that participates in the development of DCs. CD40-reactive NAbs restored normal phenotypes of DCs in patients. The maturation process induced by CD40-reactive NAbs was accompanied by an increased IL-10 and decreased IL-12 production. The transcription factor analysis revealed distinct signaling pathways operated by CD40-reactive NAbs compared to those by CD40 ligand. These results suggest that B cells promote bystander DC development through NAbs and the interaction between NAbs and DCs may play a role in steady-state migration of DCs.
Port isolation enhancement via active integration for a UWB MIMO antenna system (2015)

In this paper, a new approach of port isolation for UWB MIMO antennas is investigated through active integration with a power amplifier (PA). Instead of 50Ω based design, a co-design approach based on the complex impedance of the PA and the antenna is adopted for better MIMO antenna matching and port isolation. Such approach does not require extra decoupling networks. The integrated antenna system covers 1.5-6GHz and shows minimum port isolation improvement of 5.5dB. The minimum efficiency and highest envelop correlation coefficient are found to be 62% and 0.115 respectively over the band 1.5-6GHz.
Codesign-extended applications (2002)

We challenge the widespread assumption that an embedded system's functionality can be captured in a single specification and then partitioned among software and custom hardware processors. The specification of some functions in software is very different from the specification of the same function in hardware - too different to conceive of automatically deriving one from the other. We illustrate this concept using a digital camera example. We introduce the idea of codesign-extended applications to deal with the situation, wherein critical functions are written in multiple versions, and integrated such that simple compiler/synthesis flags instantiate a particular version along with the necessary control and communication behavior. By capturing a specification as a codesign-extended application, a designer enables smooth migration among platforms with increasing amounts of on-chip configurable logic.
CEREBELLAR INJURY IN PRETERM INFANTS: INCIDENCE AND FINDINGS ON ULTRASOUND AND MAGNETIC RESONANCE IMAGING (2008)

Background and Objective Injury to the developing cerebellum is an increasingly recognised complication of extreme prematurity, with possible major implications for neurodevelopmental outcome. On routine cranial ultrasonography (cUS) through the anterior fontanelle (AF), visualisation of the posterior fossa structures is limited. The mastoid fontanelle (MF) provides a better view of the posterior fossa and improves the detection of cerebellar injury. In this study we investigated the incidence and characteristics of cerebellar injury in a cohort of very preterm infants, using the MF approach in addition to routine cUS through the AF, and compared cUS findings with magnetic resonance imaging (MRI). Methods A cohort of 63 preterm infants ( Results Seven infants (11%) were identified with posterior fossa haemorrhage, using the MF approach. In only two of seven infants were the lesions seen on routine AF views. MRI confirmed the findings on cUS in all cases. MRI showed punctate haemorrhages in the cerebellum in six other infants with normal cUS findings. Combining the findings on cUS and MRI, cerebellar injury was diagnosed in 13/63 infants (21%). Conclusions Cerebellar injury is a frequent finding in very preterm infants. cUS through the MF can demonstrate injury missed by the routine AF approach. However, punctate haemorrhagic lesions may still remain undetected even when the MF approach is used. The prognostic implications of these smaller lesions need further attention.
Cone-End Functionalization of Carbon Nanohorns (2006)

The cone end of carbon nanohorns is removed with a powerful but mild oxidative treatment avoiding shortening of nanohorns and formation of any type of impurities. Functionalization of carboxylic acid terminated nanohorns, with amines, alcohols, and thiols induced solubility enhancement. Intramolecular electron transfer was probed on a soluble functionalized nanohorn−pyrene hybrid material.
Digitale Subtraktionsangiographie mit Kohlendioxid unter Verwendung eines neuen Gasdosiersystems (1997)

The CO2 management system allows adequate imaging of the arteries below the diaphragm. Ease and safety of use and low costs are advantageous.
Detecting Human-Object Contact in Images (2023)

Humans constantly contact objects to move and perform tasks. Thus, detecting human-object contact is important for building human-centered artificial intelligence. However, there exists no robust method to detect contact between the body and the scene from an image, and there exists no dataset to learn such a detector. We fill this gap with HOT ("Human-Object conTact"), a new dataset of human-object contacts for images. To build HOT, we use two data sources: (1) We use the PROX dataset of 3D human meshes moving in 3D scenes, and automatically annotate 2D image areas for contact via 3D mesh proximity and projection. (2) We use the V-COCO, HAKE and Watch-n-Patch datasets, and ask trained annotators to draw polygons for the 2D image areas where contact takes place. We also annotate the involved body part of the human body. We use our HOT dataset to train a new contact detector, which takes a single color image as input, and outputs 2D contact heatmaps as well as the body-part labels that are in contact. This is a new and challenging task that extends current foot-ground or hand-object contact detectors to the full generality of the whole body. The detector uses a part-attention branch to guide contact estimation through the context of the surrounding body parts and scene. We evaluate our detector extensively, and quantitative results show that our model outperforms baselines, and that all components contribute to better performance. Results on images from an online repository show reasonable detections and generalizability.
Abstract LB-13: Hyaluronic acid-based CD44 targeted nanoparticle delivery of combination MDR1 siRNA/paclitaxel to overcome drug resistance in ovarian cancer (2014)

Abstract A major obstacle in the success of chemotherapy in ovarian cancer is the emergence of multidrug resistance (MDR). Overexpression of the MDR1 gene and corresponding P-glycoprotein (Pgp) efflux pumps is one of the best characterized MDR mechanisms. Although MDR1 siRNA based strategies are emerging as highly promising approaches to reverse MDR, the systemic delivery still remains a great challenge. In the present study, CD44 targeting hyaluronic acid (HA) based self-assembling nanoparticle systems were designed with MDR1 siRNA to evaluate its delivery efficiency and combination anticancer therapeutic efficacy with paclitaxel in vitro and in vivo. The results showed that HA-poly(ethyleneimine)/HA-poly(ethylene glycol) (HA-PEI/HA-PEG) nanoparticle successfully delivered MDR1 siRNA into MDR ovarian cancer cell lines, SKOV-3TR and OVCAR8TR. Western blot analysis, calcein AM retention assay, and MTT assay further demonstrated that HA-PEI/HA-PEG nanoparticles loaded with MDR1 siRNA efficiently down-regulated the expression of MDR1 and inhibited the functional activity of Pgp, and subsequently increase cell sensitivity to paclitaxel. HA-PEI/HA-PEG/MDR1 siRNA nanoparticle therapy followed by paclitaxel treatment produced a significant inhibitory effect on the drug-resistant tumor growth as compared with control groups in MDR ovarian cancer xenograft mouse models. These results indicated CD44-targeted HA-PEI/HA-PEG nanoparticle platform is an effective siRNA delivery system for potential siRNA-based anticancer therapeutics in ovarian cancer. Citation Format: Xiaoqian Yang, Arun lyer, Francis hornicek, Mansoor Amiji, Zhenfeng Duan. Hyaluronic acid-based CD44 targeted nanoparticle delivery of combination MDR1 siRNA/paclitaxel to overcome drug resistance in ovarian cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-13. doi:10.1158/1538-7445.AM2014-LB-13
QUANTITATIVE NONDESTRUCTIVE EVALUATION OF ANCHORAGE ZONE OF POST-INSTALLED ANCHOR BY USING ELECTROMAGNETIC PULSE METHOD (2019)

Quantitative nondestructive evaluation technique of anchorage zone of post-installed anchors by using electromagnetic pulse method is presented. For quantitative evaluation, several indexes are introduced, which are derived from received signals and their frequency spectra. The effectiveness of the technique is demonstrated by experiments using anchors installed in concrete test blocks and also those installed in an existing building.
Opening up collaboration and partnership possibilities (2016)

Purpose The purpose of this paper is to describe a unique case of a librarian–engineering faculty partnership grounded in a faculty development National Science Foundation (NSF) grant. Authors will describe processes, lessons learned, challenges and opportunities resulting from designing, implementing and evaluating a massive open online course (MOOC) focused on teaching faculty how to flip classes. Design/methodology/approach This case study presents a reflective review of the process of two unlikely collaborators who work together, write a grant, design faculty development training and develop and evaluate a MOOC. Decisions made, perspectives and lessons learned will be discussed. Findings The evolution of an NSF grant partnership involving an engineering faculty and librarian is presented. Larger issues, such as proactivity of librarians, non-traditional librarian roles and librarian versus academic identity, are raised and discussed. Originality/value This case study presents a unique type of librarian–faculty partnership, one where a librarian is a Co-PI on an NSF grant. Collaborator reflections on lessons learned, challenges and implications could be applicable to other digital/technology projects, online professional development initiatives and course design projects.
Intramolecular 1,6-Addition to 2-Pyridones. Mechanism and Synthetic Scope. (2010)

The scope and limitations of the intramolecular 1,6-addition of an enolate to a 2-pyridone moiety, a reaction that has found application in the synthesis of the lupin alkaloids, have been probed. This nucleophilic addition process has been shown to be reversible and favored in the case of (less stabilized) amide and lactam enolates, which readily form five- and six-membered bi-/tricyclic products. Alternative enolates (ketone, ester, thiolactam) and a variety of different acceptors (isoquinolinone, pyrimidinone, pyrazinone, pyridopyrazinone) have been evaluated, and a range of competing side reactions have been identified and characterized using various techniques, including in situ IR.
Abrogation by a potent gonadotropin-releasing hormone antagonist of the estrogen/progesterone-stimulated surge-like release of luteinizing hormone and follicle-stimulating hormone in postmenopausal women. (1992)

In both the rodent and primate, administration of progesterone elicits an acute surge-like release of LH in the setting of prior estrogen treatment. Whether these facilitative effects of estrogen and progesterone on gonadotropin secretion reside at pituitary or hypothalamic loci is not known. To further investigate the mechanisms by which estrogen combined with progesterone amplifies gonadotropin secretion, we studied the responses of seven estrogen-primed postmenopausal women to progesterone administration with or without cotreatment with a potent GnRH antagonist, [Ac-D2Nal1,D4ClPhe2,D3Pal3,Arg5,DGlu6(AA), DAla10]GnRH. Repetitive blood sampling for the later measurement of serum concentrations of LH, FSH, and PRL was begun 4 h before the administration of progesterone and continued for 36 h. We observed that progesterone administration after 72 h of priming with ethinyl estradiol resulted in a surge-like release of LH and FSH in all subjects. Concomitant administration of the GnRH antagonist abolished the surge-like release of both gonadotropins in all subjects. In contrast, administration of the antagonist had no effect on PRL release. These results indicate that endogenous GnRH action is an obligatory component of the progesterone-induced surge-like release of both gonadotropic hormones in the estrogen-primed human.
Crystal growth and scintillation properties of Nd doped CaF<inf>2</inf> single crystal (2009)

Nd <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> doped CaF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> single crystal scintillator has been investigated. We tried to grow 1, 5, 10, 20, 30 and 40% Nd doped CaF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> single crystals by the simple melt-solidifying method. Those sampeles are compared in terms of their X-ray excited radio luminescence spectra, transmittance, ¿-ray radiated decay time and light yield. When they are irradiated by X-ray the luminescence appears at VUV region. Transmittances of them are more than 70% at wavelengths longer than about 180 nm. In decay time kinetics, the fast components of Nd doped CaF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> are distributed in 8-40 nsec and became shorter with increasing of concentration of Nd. they are related to the Nd <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> 5d-4f VUV emission. The light yield of Nd doped CaF2 are distributed in 5-2500 photon/5.5MeV ¿ and decrease with the increasing of the amount of Nd concentrations.
Stannous Chloride as an Effective Initiator for Copolymerization of Styrene with Maleic Anhydride (1998)

ABSTRACT Stannous chloride was found to be an effective initiator for co-polymerization of styrene (ST) with maleic anhydride (MAH). The combination of stannous chloride as an electron donor and MAH as an electron acceptor monomer forms charge transfer complex to produce initiating radical for copolymerization of ST with MAH. The kinetics of copolymerization was studied in the temperature range of 30-60°C, and the activation energy was determined from Arrhenius plots of polymerization rate. The overall energy of activation as calculated from Arrhenius plot was found to be 23.8 kcal/mol. The rate of copolymerization (Rp) was found to be dependent on the [SnCl2 · 2H2 0.97 ([MAH]+[ST])3.1
Terahertz emission properties from palladiumisilicon interface (2005)

Laser terahertz (THz) emission and detection system for investigating the catalytic metal/semiconductor interface of the hydrogen sensors was proposed and developed. THz radiation from palladium/silicon structures was successfully obtained. The properties of THz radiation under hydrogen and nitrogen gas mixture were investigated. The peak amplitude of THz radiation was decreased by increasing the volume concentration of hydrogen gas. This change in the amplitude can be explained by change in the local field near the surface of silicon. This result indicates that the system a potential tool for nondestructive and noncontact measurement of the hydrogen sensors.
Alkoxyalkyl Esters of 9-( S )-(3-Hydroxy-2-Phosphonomethoxypropyl) Adenine Are Potent and Selective Inhibitors of Hepatitis B Virus (HBV) Replication In Vitro and in HBV Transgenic Mice In Vivo (2009)

Alkoxyalkyl esters of acyclic nucleoside phosphonates have previously been shown to have increased antiviral activity when they are administered orally in animal models of viral diseases, including lethal infections with vaccinia virus, cowpox virus, ectromelia virus, murine cytomegalovirus, and adenovirus. 9-(S)-(3-Hydroxy-2-phosphonomethoxypropyl)adenine [(S)-HPMPA] was previously shown to have activity against hepatitis B virus (HBV) in vitro. To assess the effect of alkoxyalkyl esterification of (S)-HPMPA, we prepared the hexadecyloxypropyl (HDP), 15-methyl-hexadecyloxypropyl (15M-HDP), and octadecyloxyethyl (ODE) esters and compared their activities with the activity of adefovir dipivoxil in vitro and in vivo. Alkoxyalkyl esters of (S)-HPMPA were 6 to 20 times more active than unmodified (S)-HPMPA on the basis of their 50% effective concentrations in 2.2.15 cells. The increased antiviral activity appeared to be due in part to the increased uptake and conversion of HDP-(S)-HPMPA to HPMPA diphosphate observed in HepG2 cells in vitro. HDP-(S)-HPMPA retained full activity against HBV mutants resistant to lamivudine (L180M, M204V), but cross-resistance to a mutant resistant to adefovir (N236T) was detected. HDP-(S)-HPMPA is orally bioavailable and provides excellent liver exposure to the drug. Oral treatment of HBV transgenic mice with HDP-(S)-HPMPA, 15M-HDP-(S)-HPMPA, and ODE-(S)-HPMPA for 14 days reduced liver HBV DNA levels by roughly 1.5 log units, a response equivalent to that of adefovir dipivoxil.
MECHANISMS OF INDIRECT ALLORECOGNITION (1998)

This is the first report on the cellular, molecular, and functional characterization of self-restricted MHC allopeptide-specific T-cell clones from animals undergoing acute rejection. Our data provide support for a biologically significant role of indirect allorecognition in allograft rejection.
Noise Model Effect upon the GAN-Synthesized Images (2020)

The article is devoted to studying of the images synthesized by Generative Adversarial Networks (GAN). The investigated networks are stimulated with the noise-like vectors of random samples fed into their inputs. The influence of changes of input noise parameters upon the properties of synthesized images is of primary interest in this research.
Nonlinear Generation of Vacuum Ultraviolet Light with an All-Dielectric Metasurface (2019)

An all-dielectric metasurface device for nonlinear generation of coherent vacuum ultraviolet will be is reported. The metasurface made of ZnO has a resonance at 394 nm and can generate vacuum ultraviolet under ultrafast laser illumination.