gebhart/patrepeval huggingface dataset:
Correlation of Lipid Peroxidation in Botrytis cinerea Caused by Dicarboximide Fungicides with Their Fungicidal Activity (1998)

Dicarboximide fungicides iprodione, vinclozolin, and procymidone were examined for their capacity to inhibit mycelial growth, to cause cellular leakage, and to cause lipid peroxidation on Botrytis cinerea isolate BC2. All three fungicides effectively inhibited the mycelial growth of the fungi. The IC(50) values were found to be about 2 µM for all three fungicides, indicating that the fungicidal activity of the individual fungicides was almost the same. The fungicides caused significant cellular leakage and lipid peroxidation on the fungi in a concentration-dependent manner. Fungicidal activity of the three individual fungicides on inhibiting mycelial growth of the fungi correlated positively well with both cellular leakage and lipid peroxidation that were caused by the respective fungicides. Positive correlations were also found between the degree of cellular leakage and lipid peroxidation following treatment with the fungicides. Our results support the view that dicarboximide fungicides exert their fungicidal activity mainly through membrane lipid peroxidation and subsequent cellular leakage from the treated fungi.
KI intolerance study: A phase 2 study to assess the safety and efficacy of TGR-1202 in pts with chronic lymphocytic leukemia (CLL) who are intolerant to prior BTK or PI3K-delta inhibitor therapy. (2017)

TPS7569 Background: Although kinase inhibitor (KI) therapies, such as ibrutinib, are generally well tolerated, intolerance is the most common reason for discontinuation (d/c) in practice (~50%, Mato et al, Blood 2016). Additionally KI interruptions (≥ 8 days) can shorten OS (Barr et al, ASCO 2015). Fortunately, data suggest that KIs have non-overlapping toxicity profiles. Therefore, pts who d/c KI due to intolerance, with ongoing CLL response, represent an unmet need. TGR-1202 is a next generation, highly-specific PI3K-delta inhibitor with nanomolar inhibitory potency. TGR-1202 is well-tolerated with a d/c rate due to AEs of 8% as demonstrated in an integrated safety analysis of 165 treated pts (Burris et al, ASCO 2016). Methods: A phase 2 investigator initiated study is being conducted to assess the safety and activity of TGR-1202 in CLL pts who are KI intolerant. KI Intolerance is defined as ≥ 1 Gr 3 or ≥ 2 Gr 2 non-heme toxicities, ≥ 1 Gr 3 neutropenia with infection or fever, and/or ≥ 1 Gr 4 heme toxicity leading to KI (BTK and/or PI3K inhibitor) d/c (Table). Toxicities must resolve to ≤ Gr 1 prior to TGR-1202 dosing. Prior KI must be d/c for ≥ 14 days without progression (PD). All eligible pts are treated with TGR-1202 (800mg oral daily) until PD, toxicity or study conclusion. Primary study endpoint is PFS. Secondary endpoints include ORR, duration of response, time to treatment failure and TGR-1202 safety profile. Peripheral blood samples are collected prior to TGR-1202, after 28 days and at PD for correlative analyses to identify markers associated with KI intolerance. The trial commenced 10/1/2016. 55 eligible pts will be enrolled in approximately 12 months with 24 months follow-up. As of 1/2017, 10 study sites are enrolling pts with 10 more to be activated. To date, 10 pts have been enrolled and treated with TGR-1202. Clinical trial information: NCT02742090. [Table: see text]
P1–445: Gene transfer of HGF by microbubble–enhanced ultrasound improves Aβ–induced memory impairment in mice (2006)

Alzheimer's disease (AD) is characterized by Aβ containing plaques in the neocortex and hippocampus. In addition to neurodegeneration, cerebrovascular abnormality is recently reported in AD. HGF (hepatocyte growth factor) is a unique multifunctional growth factor. HGF has a potential effect to induce angiogenesis, and also has neurotrophic function. Recently, we have reported that HGF improved memory and learning function after cerebral infarction in rats. Clinical trials of HGF gene therapy for peripheral vascular disease and cardiovascular disease are currently in progress. In this study, we tested whether HGF gene transfer could improve memory deficit in Aβ–infusion model. We used male ddY mice (6–8weeks old). Aβ1–40 was injected by intracerebroventricular (i.c.v.) administration into mice, using 100μl–Hamilton syringe with a 3mm, 27 gauge needle. 2 week after Aβ–40 injection into cerebroventricle, mixture of HGF gene and microbubbles were injected into cerebroventricle. After the injection, ultrasonic irradiation was applied to each mouse. 1 week after the administration of HGFgene, the water finding task and Y–Maze test were carried out according to the established procedures. Mice treated with HGF gene significantly had better performance in water finding task and in Y–maze test than mice treated with control vector. Gene transfer of HGF by microbubble–enhanced ultrasound improves Aβ–induced memory impairment in mice. HGF gene therapy might be a novel therapeutic strategy for Alzheimer's disease.
Overexpression of Mannitol-1-Phosphate Dehydrogenase Increases Mannitol Accumulation and Adds Protection Against Chilling Injury in Petunia (2005)

Petunia × hybrida (Hook) Vilm. cv. Mitchell was transformed with an E. coli gene encoding mannitol-1-phosphate dehydrogenase ( mtlD ). Four plant lines that grew on kanamycin and contained the mtlD transgene were identified. Two of these lines contained high levels of mannitol [high-mannitol lines M3 and M8; mean mannitol = 3.39 μmol·g -1 dry weight (DW)] compared to nontransformed wild-type plants (0.86 μmol·g -1 DW), while two lines had mannitol levels similar to wild-type plants (low-mannitol lines M2 and M9; mean mannitol = 1.05 μmol·g -1 DW). Transgenic and control plants were subjected to chilling stress (3 ± 0.5 °C day/0 ± 0.5 °C night, 12-hour photoperiod and 75% relative humidity) to evaluate the role of mannitol in chilling tolerance. Based upon foliage symptoms and membrane leakage after a 3-week chilling treatment, the high-mannitol containing lines, M3 and M8, were more tolerant of chilling stress than the low-mannitol containing transgenic lines, M2 and M9, and wild-type. Under nonchilling conditions mannitol was the only carbohydrate that differed among transgenic lines, but all carbohydrates were present. When subjected to chilling stress, mannitol levels dropped by 75%, sucrose by 52%, and inositol by 54% in the low-mannitol lines (M2 and M9). In M3 and M8, the high-mannitol lines, mannitol levels decreased by 36%, sucrose by 25%, and inositol by 56%, respectively. Raffinose increased 2- to 3-fold in all lines following exposure to low-temperature chilling stress. In the higher mannitol lines only 0.04% to 0.06% of the total osmotic potential generated from all solutes could be attributed to mannitol, thus its action is more like that of an osmoprotectant rather than an osmoregulator. This study demonstrates that metabolic engineering of osmoprotectant synthesis pathways can be used to improve stress tolerance in horticultural crops.
Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein (1997)

The adipose differentiation-related protein (ADRP) was first characterized as a mRNA induced early during adipocyte differentiation (Jiang, H. P., and G. Serrero. 1992. Proc. Natl. Acad. Sci. USA. 89:7856-7860). The present study demonstrates that ADRP mRNA is expressed in a variety of tissues and cultured cell lines. Immunocytochemical examination revealed that ADRP localizes to neutral lipid storage droplets in cultured murine 3T3-L1 adipocytes, murine MA-10 Leydig cells, Chinese hamster ovary (CHO) fibroblasts, and human HepG2 hepatoma cells; the association of ADRP with lipid droplets was confirmed by subcellular fractionation of MA-10 Leydig cells. In addition to ADRP, steroidogenic cells and adipocytes express the perilipins, a family of lipid droplet-associated proteins that share a highly related sequence domain with ADRP. ADRP and perilipins co-localize on lipid droplets in MA-10 Leydig cells. While ADRP was found on small lipid droplets in 3T3-L1 preadipocytes and early differentiated adipocytes, it was absent in maturing adipocytes. In contrast, perilipins were absent early during differentiation, but were found on small and large lipid droplets at later stages. The transition in surface protein composition of adipocyte lipid droplets from ADRP to perilipins occurred 3 days after the initiation of differentiation when cells displayed co-localizatioin of both proteins on the same lipid droplets. The specific localization of adipose differentiation-related protein to lipid droplets in a wide variety of cells suggests that ADRP plays a role in management of neutral lipid stores.
Photochemistry with Cyanines in the Near Infrared: A Step to Chemistry 4.0 Technologies (2019)

Cyanines covering the absorption in the near infrared (NIR) are attractive for distinct applications. They can interact either with lasers exhibiting line-shaped focus emitting at both 808 and 980 nm or bright high intensity NIR-LEDs with 805 nm emission, respectively. This is drawing attention to Industry 4.0 applications. The major deactivation occurs through a non-radiative process resulting in the release of heat into the surrounding, although a small fraction of radiative deactivation also takes place. Most of these NIR-sensitive systems possess an internal activation barrier to react in a photonic process with initiators resulting in the generation of reactive radicals and acidic cations. Thus, the heat released by the NIR absorber helps to bring the system, consisting of an NIR sensitizer and initiator, above such internal barriers. Molecular design strategies making these systems more compatible with distinct applications in a certain oleophilic surrounding are considered as a big challenge. This includes variations of the molecular pattern and counter ions derived from super acids exhibiting low coordinating properties. Further discussion focusses on the use of such systems in Chemistry 4.0 related applications. Intelligent software tools help to improve and optimize these systems combining chemistry, engineering based on high-throughput formulation screening (HTFS) technologies, and machine learning algorithms to open up novel solutions in material sciences.
(Invited) High Accuracy Aligned Wafer Bonding for Wafer-Level Integration (2018)

This paper aims to present an overview of the existing wafer-to-wafer alignment technology. The development of optical alignment methods will be reviewed with respect to applications requirements evolution over time. An overview of the different factors contributing to the overall misalignment budget and how they are controlled now, or will be in the future, in order to meet the stringent requirements will be presented with examples.
Loss of motility-related protein 1 (MRP1/CD9) and integrin ?3 expression in endometrial cancers (2001)

These findings suggested that the analysis for the expression statuses of MRP1/CD9 and integrin alpha3 may provide important information on the clinical behavior of endometrial cancer.
Progress in thin-film silicon solar cells based on photonic-crystal structures (2018)

We review the recent progress in thin-film silicon solar cells with photonic crystals, where absorption enhancement is achieved by using large-area resonant effects in photonic crystals. First, a definitive guideline for enhancing light absorption in a wide wavelength range (600–1100 nm) is introduced, showing that the formation of multiple band edges utilizing higher-order modes confined in the thickness direction and the introduction of photonic superlattice structures enable significant absorption enhancement, exceeding that observed for conventional random scatterers. Subsequently, experimental evidence of this enhancement is demonstrated for a variety of thin-film Si solar cells: ∼500-nm-thick ultrathin microcrystalline silicon cells, few-µm-thick microcrystalline silicon cells, and ∼20-µm-thick thin single-crystalline silicon cells. The high short-circuit current densities and/or efficiencies observed for each cell structure confirm the effectiveness of using multiple band-edge resonant modes of photonic crystals for enhancing broadband absorption in actual solar cells.
IL-6 Is Required for Airway Mucus Production Induced by Inhaled Fungal Allergens (2009)

Allergic asthma is caused by inhaled allergens and is characterized by airway eosinophilia, as well as mucus hypersecretion, which can lead to airflow obstruction. Despite the association of increased IL-6 levels with human atopic asthma, the contribution of IL-6 to the development of allergic airway inflammation triggered by inhaled allergens remains unclear. In this study, we examined the role of IL-6 in a mouse model of allergic airway inflammation induced by direct airway exposure to extracts of Aspergillus fumigatus, a common allergen in humans. We show that inhaled A. fumigatus extracts rapidly trigger the production of IL-6 in the airways. IL-6 appears to be dispensable for the recruitment of eosinophils to the lung during the development of allergic airway inflammation. However, IL-6 is essential for mucus hypersecretion by airway epithelial cells triggered in response to inhaled A. fumigatus Ags. Impaired mucus production caused by IL-6 deficiency correlates with a severe reduction in the levels of IL-13, a major inducer of mucin glycoproteins. Thus, IL-6 is a key regulator of specific hallmark features of allergic airway inflammation and it could be a potential target for pulmonary diseases that are associated with goblet cell metaplasia and mucus hypersecretion.
Robust Estimation of Road Frictional Coefficient (2011)

Knowledge of tire force potential, i.e., tire-road frictional coefficient, is important for vehicle active safety systems because tire-road friction is an effective measure of the safety margin of vehicle dynamics. For vehicle handling dynamics, the frictional coefficient is highly coupled with tire slip angle, therefore, they need to be estimated simultaneously when the latter is not measured. This paper presents an estimation algorithm based on a robust adaptive observer methodology. Stability and robustness of this observer are analyzed numerically. The performance is analyzed using computer simulations and experiments under various road and steering conditions.
Enhancement of the Rate of Photocatalytic Degradation on TiO2 of 2- Chlorophenol, 2,7-Dichlorodibenzodioxin, and Atrazine by Inorganic Oxidizing Species (1991)

Aqueous solutions of some contaminants (2-chlorophenol, 2,7-dichlorodibenzodioxin and atrazine) are completely degraded to CO 2 (cyanuric acid for atrazine) by irradiation of a dispersion of TiO 2 particles with light (>340 nm). Addition of inorganic oxidizing species modify the rate of disappearance of the initial compounds as well as intermediates and final products formation. Peroxydisulfate and periodate enhance in a significant extent the rate of formation of the final products
Chemoenzymatic Synthesis of the 9-Deoxy- 9-fluoro-[3-13C]-NeuAc-α-(2→6)-[U-13C]-Gal-β- Sequence on an Intact Glycoprotein (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTChemoenzymatic Synthesis of the 9-Deoxy- 9-fluoro-[3-13C]-NeuAc-α-(2→6)-[U-13C]-Gal-β- Sequence on an Intact GlycoproteinTatsuo Miyazaki, Tohru Sakakibara, Hajime Sato, and Yasuhiro KajiharaView Author Information Graduate School of Integrated Science, and Faculty of Science Yokohama City University, 22-2, Seto, Kanazawa-ku Yokohama 236-0027, Japan Bruker Japan Co., Ltd. 21-5, Ninomiya, 3-chome, Tsukuba Ibaraki 305-0051, Japan Cite this: J. Am. Chem. Soc. 1999, 121, 6, 1411–1412Publication Date (Web):January 29, 1999Publication History Received17 August 1998Published online29 January 1999Published inissue 1 February 1999https://pubs.acs.org/doi/10.1021/ja982950ehttps://doi.org/10.1021/ja982950erapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views276Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Carbohydrates,Conformation,Degradation,Nuclear magnetic resonance spectroscopy,Peptides and proteins Get e-Alerts
ChemInform Abstract: Radical and Palladium‐Mediated Cyclizations of ortho‐Iodo Benzyl Enamines: A Scope and Limitation Study. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Figure 3 from Central Role of IFNγ–Indoleamine 2,3-Dioxygenase Axis in Regulation of Interleukin-12–Mediated Antitumor Immunity (2023)

Supplementary Figure 3 from Central Role of IFNγ–Indoleamine 2,3-Dioxygenase Axis in Regulation of Interleukin-12–Mediated Antitumor Immunity
Longitudinal compression of short laser pulses in air (2004)

We have performed laboratory experiments to study long distance propagation of large bandwidth ultrashort laser pulses in air. Initial pulse length, frequency chirping, and laser pulse energy were varied where the maximum propagation distance was up to 105 m. We have demonstrated the compression of initially negatively chirped low intensity laser pulses due to the linear group velocity dispersion of air. The characteristics of the compressed pulse such as pulse duration and spectral chirping were found to be significantly affected by the laser pulse intensity, with higher intensities corresponding to longer minimum compressed pulse duration.
A comparison of state-of-the-art NMOS and SiGe HBT devices for analog/mixed-signal/RF circuit applications (2004)

RF CMOS performance from a 90nm derivative communications process technology is compared to SiGe BJT performance. NMOS performance at f/sub T//f/sub max/ = 209/248 GHz (70nm) and f/sub T//f/sub max/ = 166/277 GHz (80nm) with F/sub min/ at 0.3 dB (2GHz) and 0.6 dB (10GHz) suggests there is no major reason to implement SiGe HBTs BiCMOS in an integrated communications process.
Electrically conductive adhesives as cell interconnection material in shingled module technology (2018)

Modules, in which pre-cut crystalline silicon solar cells – or shingles – are assembled into solar modules by placing the pre-cut cells in a shingle-like way on top of each other, have gained a lot of market attention in the last years. Such cell lay-up in the module has as main advantage an increased module output, due to more efficient packing without inactive space between cells. An additional benefit is that no important modifications to the cell production process are needed. The first commercial market-available modules use electrically conductive adhesives (ECAs) to connect the pre- cut cells into strings. This paper will demonstrate that using ECAs with optimized properties will result in reliable solar modules. Adhesive properties such as adhesion strength, Young’s modulus, volume resistivity and contact resistance are shown in combination with the thermocycle reliability data of ECA-assembled modules. Application techniques suitable for high-volume manufacturing are demonstrated.
A modeling study of the effect of fasting on bilirubin kinetics in Gilbert's syndrome (1981)

The mechanism of fasting hyperbilirubinemia (FH) is not fully understood. We investigated basal bilirubin kinetics in 20 Gilbert's patients and in 7 healthy volunteers. The study was repeated in seven of these Gilbert's patients after 48-h fasting. A two-compartment model proved to be adequate for interpreting crystalline bilirubin kinetics in these individuals. The parameters of bilirubin kinetics were estimated by employing a maximum likelihood parameter estimation technique. Consistency of the model and uniqueness of the estimated parameter values (from the covariance matrix) were shown. Our results confirmed previous observations regarding impaired bilirubin kinetics in Gilbert's patients as compared to controls. The main results obtained from kinetic studies in Gilbert's patients after fasting were i) no modification in the bilirubin clearance, and ii) a more than twice increase of bilirubin turnover. These data indicate that FH is related to an increased bilirubin production (mainly intrahepatic). Furthermore, evidence arises from this study that the bilirubin tolerance test is a useful diagnostic test for Gilbert's syndrome.
Analysis for collapse behavior of resist pattern in short develop time process using atomic force microscope (2005)

Adhesion property of resist is characterized with DPAT (direct peeling with atomic force microscope (AFM) tip) method using 193 nm resist patterns of 180 nm dot shape which were developed for various developing time between 12 and 120 seconds in order to analyze the phenomenon which the short develop time process had led to suppress the pattern collapse. Surface free energy and refractive index of resist film treated with the developing time were also investigated from a thermodynamic point of view. The balance model among surface energy was adopted for analyzing intrusion phenomenon of developer solution into the resist-substrate interface. It can be explained quantitatively that the intrusion energy of developer solution acts to weaken the adhesion strength of resist pattern to the substrate. Furthermore, the intrusion energy became larger with increasing developing time. Analysis with the DPAT method indicates that the pattern collapse occurs accompanied with interface and cohesion destruction. Interface-scientifically speaking, the short develop time process proved to be effective to suppress the pattern collapse because of higher adhesion energy of the resist pattern to the substrate in shorter developing time.
Non-target mass spectrometry analysis of NDMA precursors in advanced treatment for potable reuse (2018)

Non-target high-resolution mass spectrometry was used to track the occurrence and removal of NDMA precursors during advanced treatment for reuse.
Field-Plate Engineering for HFETs (2005)

This paper reports on the analytical approach for designing field plates for reducing the electric field in the channel and at the surface of heterostructure field-effect transistors (HFETs) for a given drain voltage, with the smallest possible increase of the gate capacitance. The analytical calculations for GaN-based HFETs are in good agreement with the two-dimensional numerical simulations.