gebhart/patrepeval huggingface dataset:
.pi.- and .sigma.-Acetoxy radicals (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.pi.- and .sigma.-Acetoxy radicalsP. S. Skell and D. D. MayCite this: J. Am. Chem. Soc. 1981, 103, 4, 967–968Publication Date (Print):February 1, 1981Publication History Published online1 May 2002Published inissue 1 February 1981https://pubs.acs.org/doi/10.1021/ja00394a055https://doi.org/10.1021/ja00394a055research-articleACS PublicationsRequest reuse permissionsArticle Views160Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lipocalin-type prostaglandin D synthase produces prostaglandin D 2 involved in regulation of physiological sleep (2006)

Prostaglandin (PG) D2 has been proposed to be essential for the initiation and maintenance of the physiological sleep of rats because intracerebroventricular administration of selenium tetrachloride (SeCl4), a selective inhibitor of PGD synthase (PGDS), was shown to reduce promptly and effectively the amounts of sleep during the period of infusion. However, gene knockout (KO) mice of PGDS and prostaglandin D receptor (DP1R) showed essentially the same circadian profiles and daily amounts of sleep as wild-type (WT) mice, raising questions about the involvement of PGD2 in regulating physiological sleep. Here we examined the effect of SeCl4 on the sleep of WT and KO mice for PGDS and DP1R and that of a DP1R antagonist, ONO-4127Na, on the sleep of rats. The i.p. injection of SeCl4 into WT mice decreased the PGD2 content in the brain without affecting the amounts of PGE2 and PGF(2alpha). It inhibited sleep dose-dependently and immediately after the administration during the light period when mice normally sleep, increasing the wake time; and the treatment with this compound resulted in a distinct sleep rebound during the following dark period. The SeCl4-induced insomnia was observed in hematopoietic PGDS KO mice but not at all in lipocalin-type PGDS KO, hematopoietic and lipocalin-type PGDS double KO or DP1R KO mice. Furthermore, the DP1R antagonist ONO-4127Na reduced sleep of rats by 30% during infusion into the subarachnoid space under the rostral basal forebrain at 200 pmol/min. These results clearly show that the lipocalin-type PGDS/PGD2/DP1R system plays pivotal roles in the regulation of physiological sleep.
Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division (2017)

Toxoplasma gondii possesses a highly polarized secretory system, which efficiently assembles de novo micronemes and rhoptries during parasite replication. These apical secretory organelles release their contents into host cells promoting parasite invasion and survival. Using a CreLox-based inducible knock-out strategy and the ddFKBP over-expression system, we unraveled novel functions of the clathrin adaptor complex TgAP1. First, our data indicate that AP1 in T. gondii likely functions as a conserved heterotetrameric complex composed of the four subunits γ, β, μ1, σ1 and interacts with known regulators of clathrin-mediated vesicular budding such as the unique ENTH-domain containing protein, which we named Epsin-like protein (TgEpsL). Disruption of the μ1 subunit resulted in the mis-sorting of microneme proteins at the level of the Trans-Golgi-Network (TGN). Furthermore, we demonstrated that TgAP1 regulates rhoptry biogenesis by activating rhoptry protein exit from the TGN, but also participates in the post-Golgi maturation process of preROP compartments into apically anchored club-shaped mature organelles. For this latter activity, our data indicate a specific functional relationship between TgAP1 and the Rab5A-positive endosome-like compartment. In addition, we unraveled an original role for TgAP1 in the regulation of parasite division. APμ1-depleted parasites undergo normal daughter cell budding and basal complex assembly but fail to segregate at the end of cytokinesis.
Programmable Logic Core Enhancements for High-Speed On-Chip Interfaces (2009)

Programmable logic cores (PLCs) offer a means of providing post-fabrication reconfigurability to a SoC design. This ability has the potential to significantly enhance the SoC design process by enabling post-silicon debugging, design error correction and post-fabrication feature enhancement. However, circuits implemented in general purpose programmable logic will inevitably have lower timing performance than fixed function circuits. This fundamental mismatch makes it difficult to use the PLC effectively. We address this problem by proposing changes to the structure of the PLC itself; these architectural enhancements enable circuit implementations with high performance interfaces. In previous work we addressed system bus interfaces, in this work we address direct synchronous interfaces. Our results show significant improvement in PLC interface timing, such that interaction with full-speed fixed-function SoC logic is possible. Our enhanced PLCs are able to implement direct synchronous interfaces running at, on average, 662 MHz (compared to 249 MHz in regular programmable logic). We are able to do this without compromising the basic structure or routiblity of the programmable fabric. At the same time, we show that the area overhead for these architectural changes was approximately 1%.
Loss-Minimization-Based Charging Strategy for Lithium-Ion Battery (2015)

In this paper, an optimal charging strategy for lithium-ion batteries is proposed to minimize charging loss. To reach this target, a one-RC electric model is employed to model the loss for the battery, and an efficiency map is measured for the charger, considering different charging currents and voltages. A dynamic programming algorithm is applied to determine the optimal charging current profiles for minimizing the losses of the battery and the charger separately and collectively. Experiment results prove that the proposed method is more efficient compared with a constant-current charging method without influencing the charging time.
ChemInform Abstract: SYNTHESIS OF NEW BILADIENE‐A,C DERIVATIVES AND THEIR CYCLIZATION TO UROPORPHYRIN III, 12‐DECARBOXYUROPORPHYRIN III AND PHYRIAPORPHYRIN III METHYL ESTERS (1976)

Abstract Mit Hilfe herkömmlicher Methoden werden zahlreiche Biladien‐"a,c‐Derivate dargestellt, deren Substitutionsmuster denjenigen des vom biologischen Standpunkt aus interessanten Uroporphyrins III (Ia), 12‐Descarboxyuroporphyrins III (Ib) bzw. Phyriaporphyrins III (Ic) entsprechen.
Thoth, a portable real-time operating system (Extended Abstract) (1977)

Thoth is a portable real-time operating system which has been developed at the University of Waterloo. Various configurations of Thoth have been running since May 1976; it is currently running on two minicomputers with quite different architectures (Texas Instruments 990 and Data General NOVA).
Beyond Spatial Auto-Regressive Models: Predicting Housing Prices with Satellite Imagery (2017)

When modeling geo-spatial data, it is critical to capture spatial correlations for achieving high accuracy. Spatial Auto-Regression (SAR) is a common tool used to model such data, where the spatial contiguity matrix (W) encodes thespatial correlations. However, the efficacy of SAR is limited by two factors. First, it depends on the choice of contiguity matrix, which is typically not learnt from data, but instead, is assumed to be known apriori. Second, it assumes that the observations can be explained by linear models. In this paper, we propose a Convolutional Neural Network (CNN) framework to model geo-spatial data (specifically housing prices), to learn the spatial correlations automatically. We show that neighborhood information embedded in satellite imagery can be leveraged to achieve the desired spatial smoothing. An additional upside of our framework is the relaxation of linear assumption on the data. Specific challenges we tackle while implementing our framework include, (i) how much of the neighborhood is relevant while estimating housing prices? (ii) what is the right approach to capture multiple resolutions of satellite imagery? and (iii) what other data-sources can help improve the estimation of spatial correlations? We demonstrate a marked improvement of 57% on top of the SAR baseline through the use of features from deep neural networks for the cities of London, Birmingham and Liverpool.
IN VIVO RED CELL GLYCOLYTIC CONTROL AND DPG‐ATP LEVELS * (1974)

Peer Reviewed
Multiplexed Holographic Optical Data Storage In Thick Bacteriorhodopsin Films (1998)

The optical data storage capacity of photochromic bacteriorhodopsin films is investigated by means of theoretical calculations, numerical simulations, and experimental measurements on sequential recording of angularly multiplexed diffraction gratings inside a thick D85N BR film.
Domain Walls in Antiferromagnetically Coupled Multilayer Films (2003)

We report experimentally observed magnetic domain-wall structures in antiferromagnetically coupled multilayer films with perpendicular anisotropy. Our studies reveal a first-order phase transition from domain walls with no net moment to domain walls with ferromagnetic cores. The transition originates from the competition between dipolar and exchange energies, which we tune by means of layer thickness. Although observed in a synthetic antiferromagnetic system, such domain-wall structures may be expected to occur in A-type antiferromagnets with anisotropic exchange coupling.
Skewed CMOS: Noise-immune high-performance low-power static circuit family (2000)

In this paper, we present a noise-immune high-performance static circuit family called skewed logic. Skewed logic circuits in comparison with Domino logic have better scalability and they are more suitable for low voltage applications because of better noise margins. Skewed logic and its variations have been compared with Domino logic in terms of delay, power and dynamic noise immunity. Comparison between skewed and Domino circuits on a 0.25µm 700 MHz 16 × 16 bits pipelined multiplier shows superior properties of skewed circuits over Domino in terms of clock power dissipation and peak current consumption.
Genetically Detoxified Mutants of Heat-Labile Toxin from Escherichia coli Are Able To Act as Oral Adjuvants (1999)

Detoxified mutants of the Escherichia coli heat-labile toxin (LT) act as mucosal adjuvants to intranasally presented coadministered antigens. Here, we compare the adjuvant activity of a panel of detoxified derivatives of LT, using both intranasal (i.n.) and oral (p.o.) routes of administration. The mutants used as adjuvants varied in sensitivity to proteases and toxicity. With keyhole limpet hemocyanin (KLH) as the bystander antigen, the immune responses to i. n. immunizations were consistently higher than the equivalent p.o. -delivered proteins. LT-G192, a mutant which demonstrates a 10-fold reduction in toxicity in vitro, demonstrated wild-type adjuvant activity both i.n. and p.o., inducing similar titers of KLH specific antibody in the sera and immunoglobulin A in local mucosal secretions as wild-type LT. In line with previous data, the nontoxic holotoxoid LT-K63 induced intermediate immune responses in both the serum and mucosal secretions which were lower than those achieved with wild-type LT but at least 10-fold higher than those measured when the antigen was administered with LT-B. Although significant levels of local and systemic anti-KLH antibodies were induced following p.o. immunization with LT-K63, cellular proliferative responses to KLH was poor or undetectable. In contrast, LT and LT-G192 induced significant T-cell responses to KLH following p.o. immunization. These proliferating cells secreted both gamma interferon and interleukin-5, suggesting that the type of immune response induced following p.o. coimmunization with LT and purified protein is a mixed Th1/Th2 response.
Supplementary Tables 1-14 from Two Distinct Routes to Oral Cancer Differing in Genome Instability and Risk for Cervical Node Metastasis (2023)

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Low-Dose Methotrexate Prevents Primary and Secondary Humoral Immune Responses and Induces Immune Tolerance to a Recombinant Immunotoxin (2018)

Recombinant immunotoxins (RITs) are chimeric proteins being developed for cancer treatment. They are composed of an Ab fragment that targets a cancer Ag and a cytotoxic portion of <i>Pseudomonas</i> exotoxin A. They are effective for patients with hematologic malignancies with defective immunity, but their efficacy against solid tumors is limited by anti-drug Ab (ADA) responses in immune-competent patients. Pre-existing Abs or immune memory owing to previous toxin exposure represent additional hurdles because they induce rapid and strong ADA responses. Here, we evaluated the efficacy of methotrexate (MTX) to prevent ADA formation against the mesothelin-targeting RIT LMB-100 in naive mice and in mice with pre-existing Abs. We found that low-dose MTX combined with LMB-100 completely suppressed the formation of ADAs in a dose- and frequency-dependent manner. Suppression of the immune response restored blood levels of LMB-100 and prevented its neutralization. Furthermore, combination of MTX with LMB-100 did not compromise the immune response against a second Ag given after stopping MTX, indicating specific immune tolerance. Adoptive transfer of splenocytes suppressed Ab responses to LMB-100 in recipient mice, indicating a durable immune tolerance. We conclude that combination of MTX and LMB-100 is effective at preventing immune responses in a durable, Ag-specific manner. We propose combining low-dose MTX in immune-competent cancer patients receiving RIT therapy to prevent immunogenicity. This approach could be applied to other immunogenic therapeutic agents and to proteins for which there is pre-existing immunity.
Sociolinguistic patterns in grammaticalization:He, they, andthosein human indefinite reference (2008)

Abstract Sociolinguistic patterns in language change are largely based on generalizations from linguistic variables consisting of lexemes or morphemes. This article takes a diachronic, corpus-based approach to the diffusion of a change in a more extensive morphosemantic function consisting of several linguistic subsystems. It focuses on the pronoun variants he, they , and those used for human indefiniteness in two contexts: (a) epicene anaphoric uses with indefinite pronouns and (b) cataphoric personal references. The quantitative corpus analyses show that the pronoun selection in Early and Late Modern English developed a greater tendency to use one pronoun type over the other in both contexts. The main data come from the Corpus of Early English Correspondence and its Extension . Statistical analyses compare the observed correlations of the pronouns with a set of social, external variables and language-internal factors. This article concludes that it is possible to establish sociolinguistic patterns in larger shifts if we account for the closely related internal developments in the language.
ATOMIC LAYER ETCHING OF SUSPENDED ULTRA-THIN STRUCTURES (2016)

We performed the first-ever demonstration of atomic layer etching (ALE) on suspended nano-devices, which were fabricated using an atomic layer deposition (ALD) on polyimide process Two thermal ALE chemistries including Sn(acac) 2 /HF and TMA/HF, were used to remove Al 2 O 3 from suspended microbridges and microbolometer-type absorption structures [2], [3]. Measurement of the thermal time constants of several microbridges after ALE was used to evaluate finite Al 2 O 3 material removal. ALE is currently limited to transistor processing, but will have substantial influence on a wide variety of microdevices. Here, we demonstrate ALE's functionality for the fabrication of ultrathin suspended structures.
Miniaturized and reconfigurable CPW square-ring slot antenna using thin film varactor technology (2011)

Ferroelectric (FE) Barium Strontium Titanate (Ba <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(1-x)</sub> Sr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> , BST) thin film varactor technology is applied to the antenna miniaturization and reconfiguration successfully. CPW square-ring slot antenna is used as a design example, and antennas with and without integrated BST varactors were fabricated and characterized. Including the total ground, the size of miniaturized antenna is 0.12λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> × 0.12λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> which is reduced by 31% compared with antenna without the BST varactors. Moreover, the frequency of the miniaturized antenna with the BST varactors is reconfigurable from 5.8 GHz to 6.1 GHz with a low DC biasing voltage of 3 V. Both E-plane and H-plane patterns were measured for the antennas. Fabrication details and measurement setup are also presented.
Chemically Cross‐Linked UHMWPE With Superior Toughness (2019)

Radiation cross-linked ultra-high-molecular-weight polyethylenes (UHMWPEs) are clinically used extensively in total joint arthroplasty due to their high wear resistance. Peroxide cross-linking of UHMWPE has been proposed to achieve this high level of wear resistance by simultaneously consolidating and cross-linking in the melt state. High temperature melting of uncross-linked and cross-linked UHMWPEs have further shown to improve the toughness. Here, we report on the wear and mechanical properties of a peroxide cross-linked and high-temperature melted UHMWPE as a function of vitamin E concentration for oxidative stabilization, peroxide concentration for cross-linking and high temperature melting temperature for toughness improvement. This method, combining consolidation and cross-linking in one step, presents an opportunity to manufacture highly wear and oxidation-resistant joint implant-bearing surfaces with much improved toughness. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2182-2188, 2019.
Development of a jet–REMPI (resonantly enhanced multiphoton ionization) continuous monitor for environmental applications (2001)

The need for a continuous monitor for environmentally important pollutants at realistic [parts-per-trillion (parts in 10(12))] concentrations measured in real time (minutes) is widely recognized. We developed an instrument that is based on supersonic-jet expansion and cooling, followed by resonantly enhanced multiphoton ionization (REMPI) into a mass spectrometer. This approach furnishes the dual selectivity of narrow-band tuned laser absorption and mass analysis. We initiated a spectroscopic characterization of the jet's collisional cooling behavior to optimize the instrument's sensitivity and selectivity, made measurements of several aromatic compounds (including polychlorinated dioxins) by use of a one-color REMPI scheme, and demonstrated a two-color excitation scheme.
OSC Community Lab: The Integration Test Bed for O-RAN Software Community (2022)

O-RAN Software Community (OSC) is an open-source project collaborated by O-RAN Alliance and Linux Foundation, aiming to develop reference software components based on 3GPP and O-RAN Alliance specifications. The OSC has twelve projects. Among them, the Integration and Testing (INT) project is responsible for testing the requirements documented in each release for end-to-end and use case testing. Three OSC Community Laboratories were built to speed up the integration and interoperability testing among different projects. This paper summarizes the software components developed by OSC projects and the status of the three OSC Community Laboratories. The activities of each laboratory, how the community collaborates, and the challenges we encountered along the way were elaborated.
Hydroxamate Based Inhibitors of Adenylyl Cyclase. Part 1. The Effect of Acyclic Linkers on P‐Site Binding. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Light Well: A Tunable Free-Electron Light Source on a Chip (2009)

The passage of a free-electron beam through a nanohole in a periodically layered metal-dielectric structure creates a new type of tunable, nanoscale radiation source--a "light well". In the reported demonstration, tunable light is generated at an intensity of approximately 200 W/cm(2) as electrons with energies in the 20-40 keV range are injected into gold-silica well structures with a lateral size of just a few hundred nanometers.
Cellular Controlled Delay TCP (C2TCP) (2018)

Cellular networks have special characteristics including highly variable channels, fast fluctuating capacities, deep per user buffers, self-inflicted queuing delays, radio uplink/downlink scheduling delays, etc. These distinguishing properties make the problem of achieving low latency and high throughput in cellular networks more challenging than in wired networks. That's why in this environment, TCP and its flavors, which are generally designed for wired networks, perform poorly. To cope with these challenges, we present C2TCP, a flexible end-to-end solution targeting interactive applications requiring high throughput and low delay in cellular networks. C2TCP stands on top of loss-based TCP and brings it delay sensitivity without requiring any network state profiling, channel prediction, or complicated rate adjustment mechanisms. The key idea behind C2TCP is to absorb dynamics of unpredictable cellular channels by investigating local minimum delay of packets in a moving time window and react to the cellular network's capacity changes very fast. Through extensive trace-based evaluations using traces from five commercial LTE and 3G networks, we have compared performance of C2TCP with various TCP variants, and state-of-the-art schemes including BBR, Verus, and Sprout. Results show that on average, C2TCP outperforms these schemes and achieves lower average and 95th percentile delay for packets.