gebhart/patrepeval huggingface dataset:
Deterrence of device counterfeiting, cloning, and subversion by substitution using hardware fingerprinting (2023)

Deterrence of device subversion by substitution may be achieved by including a cryptographic fingerprint unit within a computing device for authenticating a hardware platform of the computing device. The cryptographic fingerprint unit includes a physically unclonable function ("PUF") circuit disposed in or on the hardware platform. The PUF circuit is used to generate a PUF value. A key generator is coupled to generate a private key and a public key based on the PUF value while a decryptor is coupled to receive an authentication challenge posed to the computing device and encrypted with the public key and coupled to output a response to the authentication challenge decrypted with the private key.
A Semigraphical Method for the Solution of the Burmester Problem (1991)

Abstract The determination of the planar four-bar linkage intended to guide a rigid body through five finitely-separated configurations is known as the Burmester Problem. This is a nonlinear problem that involves finding the roots of a system of four bilinear equations in four unknowns. When solving this problem numerically, for it is evasive to other means, issues such as numerical conditioning, multiplicity of solutions and singularities must be considered. Here we present a semigraphical method of solution that reduces the problem to finding the intersections of two contours in the x-y plane of motion. The method not only produces all real solutions, by simple inspection, but also provides information about the numerical conditioning of those solutions.
Compact low-threshold hybrid silicon microring resonator lasers (2010)

Low-threshold lasing is achieved on compact hybrid silicon microring resonator devices (radii: 7.5, 12.5, 25 ¿m) through both optical and electrical pumping. The limiting factor in scaling down for sub-mA operation is the thermal impedance.
Synthesis and properties of a new class of highly reactive trivalent actinide organometallic compounds. Derivatives of bis(pentamethylcyclopentadienyl)uranium(III) (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and properties of a new class of highly reactive trivalent actinide organometallic compounds. Derivatives of bis(pentamethylcyclopentadienyl)uranium(III)Paul J. Fagan, Juan M. Manriquez, Tobin J. Marks, Cynthia S. Day, Sara H. Vollmer, and Victor W. DayCite this: Organometallics 1982, 1, 1, 170–180Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/om00061a028https://doi.org/10.1021/om00061a028research-articleACS PublicationsRequest reuse permissionsArticle Views747Altmetric-Citations144LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Coupling between two collinear air-core Bragg fibers (2004)

We characterize coupling between two identical collinear hollow-core Bragg fibers, assuming a TE01 launching condition. Using a multipole method and a finite-element method, we have investigated the dependence of the beat length between supermodes of the coupled fibers and supermode radiation losses as a function of the interfiber separation, the fiber core radius, and the index of the cladding. We established that coupling is maximal when the fibers are touching each other and decreases dramatically during the first hundreds of nanometers of separation. However, residual coupling with the strength proportional to the fiber radiation loss decreased over a long range as an inverse square root of the interfiber separation and exhibited periodic variation with interfiber separation. Finally, we considered coupling between the TE01 modes with a view to designing a directional coupler. We found that for fibers with large enough core radii one can identify broad frequency ranges in which the intermodal coupling strength exceeds supermode radiation losses by 1 order of magnitude, thus opening the possibility of building a directional coupler. We attribute such unusually strong intermode coupling both to the resonant effects in the intermirror cavity and to proximity interaction between the leaky modes localized in the mirror.
Sex-related differences in murine hepatic transcriptional and proteomic responses to TCDD (2015)

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant that produces myriad toxicities in most mammals. In rodents alone, there is a huge divergence in the toxicological response across species, as well as among different strains within a species. But there are also significant differences between males and females animals of a single strain. These differences are inconsistent across model systems: the severity of toxicity is greater in female rats than males, while male mice and guinea pigs are more sensitive than females. Because the specific events that underlie this difference remain unclear, we characterized the hepatic transcriptional response of adult male and female C57BL/6 mice to 500μg/kg TCDD at multiple time-points. The transcriptional profile diverged significantly between the sexes. Female mice demonstrated a large number of altered transcripts as early as 6h following treatment, suggesting a large primary response. Conversely, male animals showed the greatest TCDD-mediated response 144h following exposure, potentially implicating significant secondary responses. Nr1i3 was statistically significantly induced at all time-points in the sensitive male animals. This mRNA encodes the constitutive androstane receptor (CAR), a transcription factor involved in the regulation of xenobiotic metabolism, lipid metabolism, cell cycle and apoptosis. Surprisingly though, changes at the protein level (aside from the positive control, CYP1A1) were modest, with only FMO3 showing clear induction, and no genes with sex-differences. Thus, while male and female mice show transcriptional differences in their response to TCDD, their association with TCDD-induced toxicities remains unclear.
Parallel-plate mode reduction in conductor-backed slots using electromagnetic bandgap substrates (1999)

By fabricating a resonant slot over a reflecting back plate and filling the resulting parallel-plate with an appropriately designed artificial electromagnetic bandgap (EBG) structure, noticeable enhancements in both radiation pattern and bandwidth are achieved using a significantly lower profile than traditional designs. This design uses a two-dimensional artificial EBG substrate in conjunction with a reflecting plate to completely block radiation from the backside of the slot from propagating to the finite edges of the resulting parallel-plate cavity. Measured and simulated data for conductor-backed slots with homogeneous substrates and with EBG substrates are compared.
Cu-Doped ZnS Hollow Particle with High Activity for Hydrogen Generation from Alkaline Sulfide Solution under Visible Light (2008)

Visible light sensitive and highly active Cu-doped ZnS hollow photocatalyst particles “Cu-ZnS-shell” were successfully developed. These particles could generate H2 through photocatalytic decomposition of HS− ion in Na2S solution. The photoactivity under xenon lamp irradiation was 6 and 130 times higher than that of copper-free “ZnS-shell” and coprecipitated ZnS particles, respectively. “Cu-ZnS-shell” particles were prepared by doping the “ZnS-shell” particles synthesized using zinc oxide as precursor with Cu, utilizing the difference in ionization tendency between zinc and copper. Though the photoactivity of “ZnS-shell” was higher than that of coprecipitated ZnS, their photoactivity under visible light conditions was low. However, the “Cu-ZnS-shell” was active to light of wavelengths higher than 440 nm and is preferred over CdS, which requires an expensive support metal catalyst such as platinum to decompose HS− ion.
(ps2) Unlocking Biomarker Discovery: Unbiased Human Proteomics at High Scale, Sensitivity, and Accuracy (2011)

Unbiased human proteomics should be used for biomarker discovery, given that one's capacity to deduce (from the literature) sensible biomarkers for disease is severely constrained by our limited knowledge of human biology. Empiricism will rule the field for years to come. We have worked for more than a decade on building a proteomics platform that allows such empiricism. The platform utilizes a special class of aptamers, called SOMAmers that have enhanced affinities and specificities toward their target proteins. SOMAmer performance is sufficient to allow our platform to operate without pairs of affinity reagents for each target protein — in other words, we do not use “sandwiches.” Today we measure more than 1,000 human proteins from human samples (plasma, serum, tissue extracts, or other matrices), using only a small volume of sample. The measurements have limits of detection similar to those of good ELISA's, and low CV's (around 5%). We anticipate additional content in the near future — as new content is added to the platform, performance appears to get better. To date we have analyzed more than 10,000 samples from individuals, and studied a number of diseases. In most cases we have found novel (and unexpected) biomarkers, which, when used together in a small panel, offer hopes for accurate diagnostic information for patients and physicians. The first diagnostic products will enter the market soon.
Squamous Cell Lung Cancer: From Tumor Genomics to Cancer Therapeutics (2015)

Squamous cell lung cancer (SCC) represents an area of unmet need in lung cancer research. For the past several years, therapeutic progress in SCC has lagged behind the now more common non-small cell lung cancer histologic subtype of adenocarcinoma. However, recent efforts to define the complex biology underlying SCC have begun to bear fruit in a multitude of ways, including characterization of previously unknown genomic and signaling pathways, delineation of new, potentially actionable molecular targets, and subsequent development of a large number of agents directed against unique SCC-associated molecular abnormalities. For the first time, SCC-specific prognostic gene signatures and predictive biomarkers of new therapeutic agents are emerging. In addition, recent and ongoing clinical trials, including the Lung-MAP master protocol, have been designed to facilitate approval of targeted therapy-biomarker combinations. In this comprehensive review, we describe the current status of SCC therapeutics, recent advances in the understanding of SCC biology and prognostic gene signatures, and the development of innovative new clinical trials, all of which offer new hope for patients with advanced SCC.
1. Introduction au mix énergétique (2013)

Le bouquet (ou mix) énergétique se définit comme la répartition des énergies primaires (hydrocarbures, gaz, éolien, hydraulique, solaire, nucléaire, biomasse…) dans la production d’énergies directement utilisables comme l’électricité, la chaleur, etc., et ceci quelle que soit l’échelle. Sa composition résulte principalement de la disponibilité des ressources, de leurs coûts d’exploitation et des retours en termes de services rendus, de minimisation des risques et des impacts environnementaux ...
Relevance of AIF/CypA Lethal Pathway in SH-SY5Y Cells Treated with Staurosporine (2021)

The AIF/CypA complex exerts a lethal activity in several rodent models of acute brain injury. Upon formation, it translocates into the nucleus of cells receiving apoptotic stimuli, inducing chromatin condensation, DNA fragmentation, and cell death by a caspase-independent mechanism. Inhibition of this complex in a model of glutamate-induced cell death in HT-22 neuronal cells by an AIF peptide (AIF(370-394)) mimicking the binding site on CypA, restores cell survival and prevents brain injury in neonatal mice undergoing hypoxia-ischemia without apparent toxicity. Here, we explore the effects of the peptide on SH-SY5Y neuroblastoma cells stimulated with staurosporine (STS), a cellular model widely used to study Parkinson's disease (PD). This will pave the way to understanding the role of the complex and the potential therapeutic efficacy of inhibitors in PD. We find that AIF(370-394) confers resistance to STS-induced apoptosis in SH-SY5Y cells similar to that observed with CypA silencing and that the peptide works on the AIF/CypA translocation pathway and not on caspases activation. These findings suggest that the AIF/CypA complex is a promising target for developing novel therapeutic strategies against PD.
Influence of Co Addition on the Properties of Doped Tungsten (Part II) (1972)

Yamazaki, Naoyuki Son and Michiyasu Komatsu: Influence of Co Addition on the Properties of Doped Tungsten (Part II) Effects of Co addition on some properties, particularly low-temperature ductility of doped tungsten wire have been studied.In particular, wires produced by additions of 0.01`0.06weight % of Co together with common doping agents, Al2O3, SiO2 and K20 have shown a remarkably improved ductility before recrystallization.Increasing amounts of Co were effective in significantly increasing the maximum elongation.These wires at 0.39 mm diameter have shown the maximum elongation of 12`26% at room temperature after annealing, and the content of gaseous impurities in these wires have been effectively lowered.These wires containing 0.01`0.03%Co are not only remarkably ductile before recrystallization but have also superior in qualities to those of ordinary doped products after recrystallization, for example excellent in high temperature sag resistances essential to lamps and tubes as well as in ductility.
A Multidimensional Imaging and Spectroscopic Microscope (2020)

We present a multidimensional luminescence microscope for characterisation of emission from defects in diamond. We have applied the photoluminescence, hyperspectral and time-resolved luminescence imaging capabilities of this novel instrument to natural and synthetic diamonds.
ChemInform Abstract: 1‐METHYL‐1‐DIHALOMETHYLCYCLOHEXANE DERIVATIVES (1977)

Abstract o‐Kresol (I) liefert mit Bromov form (II) in basischem Milieu das Cyclohexadienon (III), das zu (IV) hydriert und dann zum Bicyclus (V) dehydrobromiert wird.
Synthesis and water sorption of standard and end-capped polylactides: the effect of morphology (2012)

This paper investigates the relationship between morphology and water sorption in polylactide (PLA) films. Standard PLAs and palmityl initiated end-capped PLAs were synthesized with various terminating end groups such as hydroxyl, acetoxy, and palmitoyl end groups. Results from wide angle X-ray scattering and atomic force microscopy were correlated with different sorption phenomena, suggesting that crystallization and microphase separation between amorphous PLA and hydrophobic end-group-rich domains reduced water sorption in PLA. The morphological changes were affected by end-group composition, molecular weight and stereoisomerism.
Perimeter Intrusion Detection with Backscattering Enhanced Fiber Using Telecom Cables as Sensing Backhaul (2022)

We report field test results of facility perimeter intrusion detection with distributed-fiber-sensing technology and backscattering-enhanced-fiber by using deployed telecom fiber cables as sensing backhaul. Various intrusive activities, such as walking/jumping at &gt;100ft distance, are detected.
Substituent Effects on the Coordination Chemistry of Metal-Binding Pharmacophores (2017)

A combination of XAS, UV-vis, NMR, and EPR was used to examine the binding of a series of α-hydroxythiones to CoCA. All three appear to bind preferentially in their neutral, protonated forms. Two of the three clearly bind in a monodentate fashion, through the thione sulfur alone. Thiomaltol (TM) appears to show some orientational preference, on the basis of the NMR, while it appears that thiopyromeconic acid (TPMA) retains rotational freedom. In contrast, allothiomaltol (ATM), after initially binding in its neutral form, presumably through the thione sulfur, forms a final complex that is five-coordinate via bidentate coordination of ATM. On the basis of optical titrations, we speculate that this may be due to the lower initial pK<sub>a</sub> of ATM (8.3) relative to those of TM (9.0) and TPMA (9.5). Binding through the thione is shown to reduce the hydroxyl pK<sub>a</sub> by ∼0.7 pH unit on metal binding, bringing only ATM's pK<sub>a</sub> close to the pH of the experiment, facilitating deprotonation and subsequent coordination of the hydroxyl. The data predict the presence of a solvent-exchangeable proton on TM and TPMA, and Q-band 2-pulse ESEEM experiments on CoCA + TM suggest that the proton is present. ESE-detected EPR also showed a surprising frequency dependence, giving only a subset of the expected resonances at X-band.
Pseudo-Relevance Feedback and Title Re-Ranking for Chinese Information Retrieval (2004)

The present study shows detailed interactions between NS80 and NS38 or other viral proteins. Sequence and structure characteristics of NS80 ensures its self-aggregation to form VFLS (either in the cytoplasm or nucleus) and recruitment of viral structural or nonstructural proteins.
Formation of Enamines via Catalytic Dehydrogenation by Pincer-Iridium Complexes (2020)

Di-isopropylphosphino-substituted pincer-ligated iridium catalysts are found to be significantly more effective for the dehydrogenation of simple tertiary amines to give enamines than the previously reported di-<i>t</i>-butylphosphino-substituted species. It is also found that the di-isopropylphosphino-substituted complexes catalyze dehydrogenation of several β-functionalized tertiary amines to give the corresponding 1,2-difunctionalized olefins. The di-<i>t</i>-butylphosphino-substituted species are ineffective for such substrates; presumably, the marked difference is attributable to the lesser crowding of the di-isopropylphosphino-substituted catalysts. Experimentally determined kinetic isotope effects in conjunction with DFT-based analysis support a dehydrogenation mechanism involving initial pre-equilibrium oxidative addition of the amine α-C-H bond followed by rate-determining elimination of the β-C-H bond.
Supplementary figures 1-9 from T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling (2023)

&lt;p&gt;Supplementary Figure 1. IL-21 producô€†Ÿon is reduced in CD4 FL T cells; Supplementary Figure 2. TCR-induced signaling effectors have different kineô€†Ÿc; Supplementary Figure 3. Idenô€†Ÿficaô€†Ÿon of T-cell subsets; Supplementary Figure 4. Distribuô€†Ÿon of T-cell subsets in FL LN; Supplementary Figure 5. Expression paô€†©erns of co-inhibitory receptors in CD8 and CD4 T-cell subsets; Supplementary Figure 6. Contribuô€†Ÿon of Tregs among CD4+TIGIT+ T cells; Supplementary Figure 7. TIGIT is a highly expressed co-inhibitory receptor in FL; Supplementary Figure 8. TIGIT expression is stable over ô€†Ÿme; Supplementary Figure 9. Recovery of TCR-induced signaling in TIGIT+ CD8+ FL T cells is robust.&lt;/p&gt;
Conformationally dynamic titanium and zirconium cationic complexes of bis(naphthoxy)pyridine ligands: structure, “oscillation” and olefin polymerization catalysis (2017)

Discrete ionic complexes {ONO<sup>SiMe<sub>2</sub>tBu</sup>}M(CH<sub>2</sub>Ph)((η<sup>6</sup>-Ph)CH<sub>2</sub>B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>) (M = Ti, 2-Ti; Zr, 2-Zr) have been prepared from the parent neutral dibenzyl precursors and B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>. Also, a neutral dichloro complex {ONO<sup>SiMe<sub>2</sub>tBu</sup>}ZrCl<sub>2</sub>(Me<sub>2</sub>NH) (3) was synthesized by the reaction of a proligand {ONO<sup>SiMe<sub>2</sub>tBu</sup>}H<sub>2</sub> (1-H2) with (Me<sub>2</sub>N)<sub>2</sub>ZrCl<sub>2</sub>(DME). The compounds were characterized by NMR spectroscopy and X-ray crystallography (for 2-Zr and 3). In the solid state, both 2-Zr and 3 feature meso-like binding of the ligand. VT NMR studies of 2-Ti and 2-Zr revealed that the former species dissociates in solution to form an outer-sphere ion pair (OSIP) that features a complicated dynamic behavior, while the latter compound retains an inner-sphere ion pair (ISIP) structure that interconverts between C<sub>s</sub>-symmetric (meso-like) and C<sub>1</sub>-symmetric (rac-like) conformations. The mechanism of this interconversion was assessed by DFT calculations and the corresponding barrier for the straightforward interconversion was calculated ().
Novel Thermoplastic Elastomers: Star-Blocks Consisting of Eight Poly(Styrene-b-Isobutylene) Arms Radiating from a Calix[8]Arene Core (1998)

Abstract The first synthesis by a core-first strategy of novel star-block copolymers consisting of eight poly(styrene- b -isobutylene) (PSt- b -PIB) arms radiating from a calix[8]arene core is described. An octafunctional methoxy calix[8]arene derivative was used to initiate the living polymerization of isobutylene (IB) to desirable molecular weights, then styrene (St) was added to obtain the sought star-blocks. Molecular weights and PSt contents were determined by triple-detector GPC and 1 H NMR spectroscopy. Star-block thermoplastic elastomers containing 17–32% PSt showed high strength and elongation (up to ∼26 MPa and &gt;500%) and relatively low melt viscosities. The mechanical and rheological properties of these star-blocks are superior to those of linear PSt- b -PIB- b -PSt triblocks. PIB-based thermoplastic elastomers may be of use as novel biomaterials.
KVM virtualization impact on active round-trip time measurements (2015)

Active measurements tools transmit probe packets between a sender and a receiver to estimate performance metrics such as round-trip time, jitter and loss. In this paper we evaluate how KVM virtualization affects measurements of performance metrics, specifically the round-trip time (RTT). To understand the impact we investigate the interplay of various environment and measurement parameters with virtualization. A number of experiments are performed in order to investigate which parameters had major impact on the RTT. The paper shows that the measurements are affected by CPU load in the host as well as network load while I/O load seemed to have limited impact.
Self-bending of a spatially asymmetric carbon dioxide laser beam in a nonlinear medium (1988)

Self-bending of a transversely nonuniform CO2 laser beam owing to the Kerr effect in CS2 is studied. The effect is used to measure the nonlinear refractive index n2 of CS2 at 10.6 μm. Self-bending can be used for ultrafast all- optical light-beam manipulation such as light-by-light deflection and nonlinear-optical switching/power limiting and for an optical streak camera.