gebhart/patrepeval huggingface dataset:
Hypopituitarisme consécutif aux atteintes cérébrales: le traumatisme cranien et l'hémorragie sous-arachnoidienne mis en cause. (2009)

La prevalence de l'hypopituitarisme est largement sous-estimee et son etiologie est souvent meconnue. Le traumatisme crânien et l'hemorragie sous-arachnoidienne constituent actuellement des causes importantes d'hypopituitarisme acquis de l'adulte. Les traumatismes crâniens representent un probleme majeur de sante publique, avec une incidence annuelle de 300 cas par 100.000 habitants, soit en Belgique 30.000 patients par an. L'hemorragie sous-arachnoidienne represente quant a elle six cas par 100.000 habitants aux USA et on l'estime a 600 nouveaux cas par an en Belgique. Dans l'hypopituitarisme secondaire aux traumatismes crâniens, 14 series retrospectives et prospectives identifient chez 1.077 patients un deficit en GH ou somatotrope (14% des patients), un deficit en ACTH ou corticotrope (14%), un deficit en LH/FSH ou gonadotrope (18%), un deficit en TSH ou thyreotrope (7%) et un deficit en ADH ou diabete insipide (4%). Dans l'hemorragie sous-arachnoidienne trois series retrospectives totalisant 110 patients rendent compte d'un deficit en GH (25%), en ACTH (15%), gonadotrope -LH/ FSH- (8,5 %), en TSH (6%) et d'un diabete insipide (4%); une seule etude prospective est disponible. Nous faisons le point sur ces donnees recentes et discutons du diagnostic et de la prise en charge de l'hypopituitarisme secondaire au traumatisme crânien et a l'hemorragie sous-arachnoidienne.
Reliable Performance Comparison of Perovskite Solar Cells Using Optimized Maximum Power Point Tracking (2019)

Performance comparison of perovskite solar cells with different architectures is nontrivial. J–V sweeps can be unreliable due to stack‐dependent output variations affected by sample preconditioning, scan rate, scan direction, and temperature. Maximum power point tracking is regarded as a more reliable performance measurement. In this study, a two‐step measuring procedure is proposed for quick and unbiased comparison of perovskite‐based solar cells. In the proposed procedure, the transient current density characterization step is used to determine optimal parameters for maximum power point tracking performance characterization. Moreover, factors affecting time limited maximum power point tracking by comparing performance and output of three different maximum power point tracking algorithms applied to devices, from three planar n‐i‐p perovskite stacks, are analyzed and identified. Numerical simulation is used to model differences and define limitations of the algorithms. As a result, it is shown that measurement delay and voltage step can have a crucial effect on maximum power point tracking output, regardless of the chosen algorithm.
In vitro and in vivo protective efficacies of antibodies that neutralize the RNA N-glycosidase activity of Shiga toxin 2 (2010)

The neutralization efficiency of the RNA-NGA of Stx2 by A subunit-specific antibodies correlate strongly with their abilities to protect HeLa cells against Stx2-mediated toxicity but only the strongest RNA-NGA-neutralizing antibodies correlate very well with both protecting HeLa cells and mice against Stx2 challenge.
An Efficient Ray-Based Modeling Approach for Scattering from Reconfigurable Intelligent Surfaces (2023)

&lt;p&gt;Reconfigurable Intelligent Surfaces (RISs), which can be implemented using metasurface technology or reflect/transmit antenna array technology, have garnered significant attention in research studies focused on both their technological aspects and potential applications. While various modeling approaches have been proposed - ranging from electromagnetic simulations and analytical integral formulations to simplified approaches based on scattering matrix theory - there remains a great need for efficient and electromagnetically-consistent macroscopic models that can accurately simulate scattering from RISs, particularly for realistic simulations of RIS-based wireless networks. Building on previous work based on the characterization of the RIS through a surface impedance (or ”spatial modulation”) function and a few parameters, in the present paper we propose a fully ray-based approach for the computation of the re-radiated field that can be easily embedded in efficient, forward ray tracing (also known as ”ray launching”) models. We validate the proposed model by comparison to well established methods available in the literature. Results show that, although the considered method is based on a completely different formulation and is much more efficient than integral formulation methods, results are almost indistinguishable in some benchmark cases.&lt;/p&gt;
Integrating biophysical crop growth models and whole genome prediction for their mutual benefit: a case study in wheat phenology (2023)

Abstract Running crop growth models (CGM) coupled with whole genome prediction (WGP) as a CGM–WGP model introduces environmental information to WGP and genomic relatedness information to the genotype-specific parameters modelled through CGMs. Previous studies have primarily used CGM–WGP to infer prediction accuracy without exploring its potential to enhance CGM and WGP. Here, we implemented a heading and maturity date wheat phenology model within a CGM–WGP framework and compared it with CGM and WGP. The CGM–WGP resulted in more heritable genotype-specific parameters with more biologically realistic correlation structures between genotype-specific parameters and phenology traits compared with CGM-modelled genotype-specific parameters that reflected the correlation of measured phenotypes. Another advantage of CGM–WGP is the ability to infer accurate prediction with much smaller and less diverse reference data compared with that required for CGM. A genome-wide association analysis linked the genotype-specific parameters from the CGM–WGP model to nine significant phenology loci including Vrn-A1 and the three PPD1 genes, which were not detected for CGM-modelled genotype-specific parameters. Selection on genotype-specific parameters could be simpler than on observed phenotypes. For example, thermal time traits are theoretically more independent candidates, compared with the highly correlated heading and maturity dates, which could be used to achieve an environment-specific optimal flowering period. CGM–WGP combines the advantages of CGM and WGP to predict more accurate phenotypes for new genotypes under alternative or future environmental conditions.
Ion Mobility Mass Spectrometry Coupled with Rapid Protein Threading Predictor Structure Prediction and Collision-Induced Dissociation for Probing Chemokine Conformation and Stability (2012)

Unique to ion mobility mass spectrometry (IM-MS) is the ability to provide collision cross section (CCS) data and the capacity to delineate any dissociation and/or unfolding of protein complexes. The strong correlation of the experimentally determined CCS with theory is indicative of the retention of native structure in the gas phase, which in turn, qualifies as a means in evaluating the IM-MS data. The assessment of IM-MS data, however, is currently impeded due to the lack of appropriate structural coordinates to use as input in the in silico calculation of theory. To address this issue, this study involves the use of rapid protein threading predictor (RAPTOR) to generate tertiary structures of closely related monomeric chemokines (MCP-1, MCP-3, MCP-4, and eotaxin) and, subsequently, utilize these models to estimate the theoretical values. Experimental CCS of both the model proteins and chemokines correlate well with theory generated by RAPTOR. All conformations for z = 5+ of chemokines fall within theoretical limits. Of the four chemokines, MCP-4 with z = 6+ appears to adopt an extended conformation, while eotaxin gradually unfolds, and the extended structures of MCP-1 and MCP-3 increase in abundance upon activation. Combining RAPTOR with IM-MS and collision-induced dissociation (CID) enables us to interrogate the conformations of homologous proteins with very similar tertiary structures.
Low molecular weight proteomic information distinguishes metastatic from benign pheochromocytoma (2005)

Metastatic lesions occur in up to 36% of patients with pheochromocytoma. Currently there is no way to reliably detect or predict which patients are at risk for metastatic pheochromocytoma. Thus, the discovery of biomarkers that could distinguish patients with benign disease from those with metastatic disease would be of great clinical value. Using surface-enhanced laser desorption ionization protein chips combined with high-resolution mass spectrometry, we tested the hypothesis that pheochromocytoma pathologic states can be reflected as biomarker information within the low molecular weight (LMW) region of the serum proteome. LMW protein profiles were generated from the serum of 67 pheochromocytoma patients from four institutions and analyzed by two different bioinformatics approaches employing pattern recognition algorithms to determine if the LMW component of the circulatory proteome contains potentially useful discriminatory information. Both approaches were able to identify combinations of LMW molecules which could distinguish all metastatic from all benign pheochromocytomas in a separate blinded validation set. In conclusion, for this study set low molecular mass biomarker information correlated with pheochromocytoma pathologic state using blinded validation. If confirmed in larger validation studies, efforts to identify the underlying diagnostic molecules by sequencing would be warranted. In the future, measurement of these biomarkers could be potentially used to improve the ability to identify patients with metastatic disease.
Synthesis of 2-Hydroxydodecyl Starch Ethers: Importance of the Purification Process (2018)

2-Hydroxydodecyl starch ethers were synthesized by reaction of 1,2-epoxydodecane with potato starch in aqueous alkaline medium. Careful attention has been given to the purification steps and more precisely to the identification and quantification of the impurities. The purification by Soxhlet extraction compared to the process by grinding required fewer steps but a longer time. The values of the MS were always around 1.1, but the recovery yields were higher for the treatment by grinding compared to Soxhlet (85 vs 63%).
Surface-Localized Chemically Modified Reduced Graphene Oxide Nanocomposites as Flexible Conductive Surfaces for Space Applications (2023)

Thermoplastic polymers are a compelling class of materials for emerging space exploration applications due to their wide range of mechanical properties and compatibility with a variety of processing methods, including additive manufacturing. However, despite these benefits, the use of thermoplastic polymers in a set of critical space applications is limited by their low electrical conductivity, which makes them susceptible to static charging and limits their ability to be used as active and passive components in electronic devices, including materials for static charge dissipation, resistive heaters, and electrodynamic dust shielding devices. Herein, we explore the microstructural evolution of electrically conductive, surface-localized nanocomposites (SLNCs) of chemically modified reduced graphene oxide and a set of thermoplastic polymers as a function of critical thermal properties of the substrate (melting temperature for semi-crystalline materials or glass transition temperature for amorphous materials). Selected offsets from critical substrate temperatures were used to produce SLNCs with conductivities between 0.6-3 S/cm and surface structures, which ranged from particle-rich, porous surfaces to polymer-rich, non-porous surfaces. We then demonstrate the physical durability of these electrically conductive SLNCs to expected stress conditions for flexible conductive materials in lunar applications including tension, flexion, and abrasion with lunar simulant. Small changes in resistance (<i>R</i>/<i>R</i><sub>0</sub> < 2) were measured under uniaxial tension up to 20% strain in high density polyethylene and up to 500 abrasion cycles in polysulfone, demonstrating the applicability of these materials as active and passive flexible conductors in exterior lunar applications. The tough, electrically conductive SLNCs developed here could greatly expand the use of polymeric materials in space applications, including lunar exploration, micro- and nano-satellites, and other orbital structures.
Bioink Formulation and Machine Learning-Empowered Bioprinting Optimization (2022)

Bioprinting enables the fabrication of complex, heterogeneous tissues through robotically-controlled placement of cells and biomaterials. It has been rapidly developing into a powerful and versatile tool for tissue engineering. Recent advances in bioprinting modalities and biofabrication strategies as well as new materials and chemistries have led to improved mimicry and development of physiologically relevant tissue architectures constituted with multiple cell types and heterogeneous spatial material properties. Machine learning (ML) has been applied to accelerate these processes. It is a new paradigm for bioprinting. In this review, we explore current trends in bioink formulation and how ML has been used to accelerate optimization and enable real-time error detection as well as to reduce the iterative steps necessary for bioink formulation. We examined how rheometric properties, including shear storage, loss moduli, viscosity, shear-thinning property of biomaterials affect the printability of a bioink. Furthermore, we scrutinized the interplays between yield shear stress and the printability of a bioink. Moreover, we systematically surveyed the application of ML in precision in situ surgical site bioprinting, closed-loop AI printing, and post-printing optimization.
A novel putative transcription factor protein MYT2 that preferentially binds supercoiled DNA and induces DNA synthesis in quiescent cells (2000)

Myelin transcription factor 2 (MYT2), a putative transcription factor found in the human central nervous system, was cloned from an expression cDNA library from human T-cells. MYT2 shares weak similarity to bacterial type I topoisomerases and shares 63% sequence identity to a replicase from Leuconostoc mesenteroides. MYT2 preferentially binds supercoiled DNA (scDNA). Incubation of MYT2 and scDNA at or above equal molar ratios generated topoisomer-like patterns that were abolished by deproteination. Thus, MYT2 appears to relax scDNA via a non-enzymatic mechanism. The banding pattern of MYT2-scDNA complexes was shown to be quantisized, saturable and sequence-independent. Microinjection of MYT2 mRNA induced G(o) growth-arrested NIH 3T3 cells to enter the S phase of the cell cycle.
Impact of Shoulder Injuries on Quality of Life for Retired National Basketball Association Players: A Survey Study (2019)

Athletes in the National Basketball Association (NBA) are at risk of sport-related injuries due to the frequent jumping, pivoting, and overhead movements that constantly strain the musculoskeletal system. A comprehensive understanding of how shoulder injuries affect athletes during their NBA careers and into retirement has not been studied.
Extended Abstract Rotopod: A Novel Approach To Efficient Legged Locomotion (2007)

A number of attempts have been made to integrate the efficiency of wheeled locomotion with the terrain versatility of legged locomotion, e.g., Univ.Michigan’s Rhex platform and Case Western’s Whegs. Those platforms cast legs as rotating spokes placed traditionally at the corners of a rectangular platform. In this paper, we present an alternate approach, with three legs radiating down from a central hub. The energy to move the platform is generated by a rotating reaction mass mounted at the hub and, at rest, rotating parallel to the ground plane.\nOur approach is to construct a platform whose natural, uncontrolled motion is energy efficient and useful, and which requires only a small amount of control to produce effective locomotion. We describe the platform and analyze the characteristics of its uncontrolled motion. Several strategies to produce directed motion will be presented and evaluated. Simulation models and a prototype platform have been built and will be discussed.
Identification of Markers Associated with Quantitative Trait Loci in Chickens by DNA Fingerprinting (1991)

Three approaches for identifying VNTR alleles associated with quantitative traits in chickens are described. One approach is based on the comparison of well-defined selected and non-selected control strains. The second approach is based on analyzing chickens within a breeding population ranked according to specific traits and the third approach involves segregation analysis. In this latter approach a large number of offspring of a single male segregating for a quantitative trait are produced and tested for trait association of the male DNA fingerprinting bands. In all cases pooled DNA samples of birds, rather than individual samples, are analyzed and band intensity is assumed to reflect the relative frequency of an allele. Examples from the literature and from our laboratory indicate that these methods permit the identification of DNA fingerprinting bands associated with quantitative traits. After developing locus-specific probes for these bands it should ultimately be possible to detect and map quantitative trait loci.
Transport In and Optimization of Aligned-Channel Li-Ion Electrode Architectures (2021)

Advanced electrode architectures utilizing aligned channels show promise in improving rate performance. However, the relationship between aligned channel structure and electrode-scale ion transport rate must be understood to enable optimization of electrode designs. Using a physics-based P2D model for experimental analysis, the impact of aligned channel electrode structures on cell rate capability is quantified. Results are used for optimization of aligned-channel volume fraction and electrode mass loading. Anticipated improvements in volumetric energy density ${E}_{V}$ over optimal ${E}_{V}$ for conventional, slurry-cast electrodes are shown to be significant at high rates and with electrodes characterized by high tortuosity.
In Situ Surface EXAFS Study of an Underpotentially Deposited Silver Monolayer on Gold (111) (1993)

Fluorescence detected surface extended x‐ray absorption fine structure (EXAFS) has been used to probe the structure of underpotentially deposited Ag on a Au(111) surface from an aqueous solution using sodium perchlorate as the electrolyte. Silver is shown to be fully reduced on the surface with observed bond distances of and for silver‐silver and silver‐gold near neighbors, respectively. Data is obtained with the polarization of the incident x‐ray beam both parallel and perpendicular to the electrode surface. From this, we show that the silver monolayer is commensurate with the substrate and that the Ag ad‐atoms occupy three‐fold hollow sites. In addition to backscattering from gold and silver near neighbors, backscattering from oxygen, presumably adsorbed water is observed. We have studied this at different electrode potentials (+0.7, +0.5, −0.1 V vs. ). At all three potentials the measured silver‐oxygen distance is the same: . This is contrasted to another system where this previously has been studied, Pb on Ag(111), where the metal‐oxygen distance varies with applied potential.
Relation Analysis between Intracellular Distribution of Nanomateriarls, ROS Generation and DNA Damage (2012)

With recent development of nanotechnology, nanomaterials (NMs) have been developed with innovative function and expected to cause a paradigm shift in various industry such as cosmetics, medicine and food. NMs begin to establish firm position in Japan as base of various industrials, in fact, a part of them have been already applied to various products. On the other hand, it is suggested that these innovative properties may induce unknown biological responses. It is concerned about the effect of these innovative properties to human health. Based on these situations, to evaluate risk of NMs, it is started to collect information about safety of NMs (Nano Safety Science). With this in mind, we analyzed the relationship between particle size and the in vitro effect of amorphous nanosilica (nSP) using human keratinocyte cells (HaCaT). Our results indicate that exposure to nSP of 70 nm diameter (nSP70) induced an elevated level of reactive oxygen species (ROS), leading to DNA damage. On the other hand, a markedly reduced response was observed using submicron-sized silica particles. Next, we investigate relationship between endocytosis, generation of ROS and DNA damage using endocytosis inhibitor, cytochalasin D (CytoD). As result, CytoD -treatment reduced nSP70-mediated ROS generation and DNA damage. This suggested that endocytosis is involved in nSP70-mediated cellular effects. Thus, particle size affects amorphous silica-induced ROS generation and DNA damage in HaCaT cells. We believe that clarification of the endocytosis pathway of nSP will provide useful information for hazard identification as well as the design of safer forms of nSP.
Six New Heterocyclic Stilbene Oligomers from Stem Bark of Shorea hemsleyana (2001)

From the stem bark of Shorea hemsleyana (Dipterocarpaceae), four new stilbenoids with one or two dihydrofuran ring(s) [hemsleyanols C, D, hemsleyanosides E, F, and (-)-ampelopsin H] and a new stilbenoid with a carbonyl group (hemsleyanol E) were isolated.The structures including the relative configuration were elucidated on the basis of spectroscopic and chemical evidence.Stilbenoids are known to being abundantly distributed in Dipterocarpaceaeous plants as a variety of resveratrol (3,5,4'-trihydroxystilbene) oligomers after the homogeneous oligomeriztion. 1, 2Some of their derivatives displayed the biological properties such as chemopreventive activity of cancer, 3 antiinflammatory activity, 4 inhibition of histamine release 5 and gastric ATPase 6 .Stilbenoids are, therefore, useful resource of lead compounds for drug development.In continuation of our phytochemical studies on Dipterocarpaceous plant, the structures of stilbenoids in Hopea, 7 Vatica, 8, 9 and Shorea 10, 11 were characterized.The distinctive cytotoxicty found in some stilbenoids was discussed. 12 the preceding paper, the structures of stilbene oligomers, hemsleyanols A-C 10 and C-glycosyl stilbene oligomers, hemsleyanosides A-D 11 composed of some resveratrol units in the bark of Shorea hemsleyana, were revealed.Further investigation of an acetone extract of the bark resulted in isolation of six new stilbenoids named hemsleyanols C (1), D (2) and E (4) and hemsleyanosides E (5) and F (6) together with (-)-ampelopsin H (3).This paper deals with their structure elucidation including the relative configuration.Hemsleyanol C (1), a brown amorphous powder, showed a positive reaction in the Gibbs reagent.The absorption band (285 nm) in the UV spectra showed the presence of aromatic rings.The [M-H] -ion
How Designing for People With and Without Disabilities Shapes Student Design Thinking (2016)

Despite practices addressing disability in design and advocating user-centered design (UCD) approaches, popular mainstream technologies remain largely inaccessible for people with disabilities. We conducted a design course study investigating how student designers regard disability and explored how designing for both disabled and non-disabled users encouraged students to think about accessibility throughout the design process. Students focused on a design project while learning UCD concepts and techniques, working with people with and without disabilities throughout the project. We found that designing for both disabled and non-disabled users surfaced challenges and tensions in finding solutions to satisfy both groups, influencing students' attitudes toward accessible design. In addressing these tensions, non-functional aspects of accessible design emerged as important complements to functional aspects for users with and without disabilities.