gebhart/patrepeval huggingface dataset:
Monitoring the site-specific incorporation of dual fluorophore-quencher base analogues for target DNA detection by an unnatural base pair system (2011)

We developed intramolecular dual fluorophore-quencher base analogues for site-specific incorporation into DNA by an unnatural base pair replication system. An unnatural base pair between 7-(2-thienyl)-imidazo[4,5-b]pyridine (Ds) and 2-nitro-4-propynylpyrrole (Px) exhibits high fidelity in PCR amplification, and the 2-nitropyrrole moiety of Px acts as a quencher. Deoxyribonucleoside triphosphates of Px linked with a fluorophore (Cy3, Cy5 or FAM) were chemically synthesized, and the fluorescent properties and the enzymatic incorporation of the fluorophore-linked dPxTPs into DNA were examined in PCR amplification. The fluorophore-linked dPxTPs were site-specifically incorporated by PCR into DNA, opposite Ds in templates, with high selectivity. Furthermore, we found that the fluorescence of the triphosphates was partially quenched, but increased upon their incorporation into DNA. These dual fluorophore-quencher base analogues would be useful for site-specific DNA labeling and for monitoring the amplification products of target nucleic acid molecules with a specific sequence. We have demonstrated the utility of the fluorophore-linked Px substrates and the Ds-Px pairing in real-time quantitative PCR for target DNA molecule detection.
Development of a Long Life Ka-band Inverted Coaxial Magnetron for Use in an Airborne Military Radar System (2006)

This paper describes the design and development of a long life Ka-band inverted coaxial magnetron for an airborne military radar system. The use of particle-in-cell and finite element codes to model the magnetron will be described.
Natural Molecules for Healthy Lifestyles: Oleocanthal from Extra Virgin Olive Oil (2019)

Extra virgin olive oil (EVOO) is the main source of fat in the Mediterranean diet. Phenolic compounds of EVOO, in particular, secoiridoids, are minor components that have generated special interest due to their positive effects on human health, supported by several clinical trials. This review summarizes the most recent findings on the pharmacological properties and action's mechanisms of secoiridoid oleocanthal, focusing attention on inflammation, oxidative stress, cancer, neurodegenerative processes, and rheumatic diseases. Being of relevance to the clinical effects of EVOO intake, the bioavailability and biotransformation of EVOO polyphenols are addressed. Moreover, this review summarizes the factors that may influence the oleocanthal concentration in EVOO. With the growing incidence of age- and lifestyle-related diseases, the current data indicated that the administration of EVOO rich in secoiridoids may be helpful in the prevention or treatment of different pathologies with an inflammatory component. Although promising, the future raises several questions and challenges, which are discussed here. The real beneficial effects of olive oil phenols on human health need to be clarified in new, well-designed clinical studies.
Thioredoxin Reductase Is Essential for Protection ofNeisseria gonorrhoeaeagainst Killing by Nitric Oxide and for Bacterial Growth during Interaction with Cervical Epithelial Cells (2008)

In Neisseria gonorrhoeae, the MerR family transcription factor NmlR activates 3 operons in response to disulfide stress. In the present study, we show that trxB, a monocistronic operon under the control of NmlR, encodes a functional thioredoxin reductase. It is shown that neisserial TrxB has biochemical properties similar to those of its homologue from Escherichia coli. Analysis of a trxB mutant of N. gonorrhoeae showed that it was more sensitive to disulfide stress and to stress induced by organic hydroperoxides, superoxide, and nitric oxide than wild-type gonococcus. TrxB was found to be essential for the microaerobic induction of aniA and norB, the genes encoding nitrite reductase and nitric oxide reductase, respectively. The importance of TrxB during natural infection was demonstrated by the fact that the survival of gonococci within human cervical epithelial cells, as well as biofilm formation on these cells, was greatly reduced for a trxB mutant compared with a wild-type strain.
Эффективность стратегий достижения и поддержанияконтроля над бронхиальной астмой в условиях реальнойклинической практики: данные многоцентровогоисследования СТРЕЛА-АСТ (2010)

Целью исследования стало сравнение эффективности различных стратегий достижения контроля с позиции его поддержания у пациентов с персистирующей бронхиальной астмой в условиях реальной клинической практики с помощью теста по контролю над астмой (ACT ТМ ). Многоцентровое проспективное наблюдательное исследование было проведено в 19 центрах России по единому протоколу. Статистический анализ эффективности выполнен для данных, полученных от 543 пациентов. Для статистической обработки результатов использован пакет программ Statistica 6.0. В условиях реальной клинической практики применение комбинированной терапии с нарастанием дозы (группа А) или в стабильном объеме (В) обеспечивает достижение контроля у большинства пациентов уже в первые 12 нед. терапии. В течение следующих 12 нед. наблюдения после достижения контроля доля контролируемых пациентов в группах А и В не сокращалась. Снижение объема терапии ассоциировано с уменьшением доли контролируемых пациентов и кратным увеличением вероятности потери контроля.
Realization of a Low Energy State of an Electron Beam in Uniform Channel (2018)

Earlier it was shown that between two virtual cathodes in a channel consisting of 3 uniform tubes with different radii a low energy state of electrons with the potential close to the cathode potential appears. In the present paper we show that the low energy state also appears in uniform tube but between a real tubular cathode and a magnetic mirror.
From Canonical Poses to 3D Motion Capture Using a Single Camera (2009)

We combine detection and tracking techniques to achieve robust 3D motion recovery of people seen from arbitrary viewpoints by a single and potentially moving camera. We rely on detecting key postures, which can be done reliably, using a motion model to infer 3D poses between consecutive detections, and finally refining them over the whole sequence using a generative model. We demonstrate our approach in the cases of golf motions filmed using a static camera and walking motions acquired using a potentially moving one. We will show that our approach, although monocular, is both metrically accurate because it integrates information over many frames and robust because it can recover from a few misdetections.
The origins of a modern bureaucracy (2007)

Publisher: ClioPress. Editoria digitale per la didattica e la ricerca storica
Pages: 132
Language: Italian
NBN: http://nbn.depositolegale.it/urn:nbn:it:unina-22055
Abstract: The transition from the French Decade to the years of the Second Restoration represents a qualifying moment in the history of Southern Italy. Closely connected to the topic of the State-Building, studied in its peculiar traits, the construction of a modern bureaucracy begins precisely from that point, contributing to a greater articulation of the Bourbon period. The core of the volume is the structure of the Ministry of Finance, investigated by focusing on its personnel.
Through extensive and unpublished records, combined with a consistent bibliography, broadly composed of primary sources, the book crosses different subjects: from governmental action to the institutional one; from the individual prospective to that of the territory. The growth of the administration, which the investigation reveals, seems to influence in many aspects the profile of southern society, suggesting a dynamic dimension of the State. In the background, there was a territory far from being inactive: in fact, the State confirms his role of place identifier and classifier, even through a process of defining a bureaucratic identity in relation to the local dimensions in which it operates.
Indice
Nota ai testi
Introduzione
Tra storia e amministrazione
I. Il Regno
Tra territorio tutelato e territorio controllato.
L’amministrazione generale di Acque e Foreste nel Decennio francese
II. La Capitale
La costruzione di un’identita burocratica.
Gli impiegati delle imposte indirette di Napoli nel primo Ottocento
L’amministrazione generale delle Poste tra decennio francese e secondarestaurazione. Verso la creazione di un corpo
III. Le Province
L’articolazione periferica del ministero delle Finanze nel Mezzogiornoborbonico di primo Ottocento. Il caso di Terra di Lavoro
Indice dei nomi
Indice dei luoghi
[Gastrointestinal peptides among new therapeutic agents used in type 2 diabetes]. (1999)

The pharmacological arsenal available today for the treatment of type II diabetes is often insufficient to allow optimal control of the disease. Each agent corrects only one or a few of the multiple defects that characterise type II diabetes. Currently, new drugs are under development that target several of the clinical abnormalities. These agents include the gastrointestinal peptides, glucagon-like polypeptide-1 (GLP-1) and amylin, and their analogues. New rapid- and long-acting insulin analogues will also constitute interesting treatment alternatives.
CONCUSSION IN PROFESSIONAL FOOTBALL (2009)

When the immunohistochemical results are extrapolated to professional football players, concussions result in no or minimal brain injury. Repeat impacts at higher velocity or with a heavier mass impactor cause extensive and distant diffuse axonal injury. Based on this model, the threshold for diffuse axonal injury is above even the most severe conditions for National Football League concussion.
Attentional blinks as errors in temporal binding (2010)

In the attentional blink, the second of two targets in a Rapid Serial Visual Presentation (RSVP) stream is difficult to detect and identify when it is presented soon but not immediately after the first target. We varied the Stimulus Onset Asynchrony (SOA) of the items in the stream and the color of the targets (red from gray or vice versa), and looked at the responses to the second target. Exact responses to the second target (zero positional error) showed a typical attentional blink profile, with a drop in performance for an interval of 200–500 ms after the first target. Approximate responses (positional error no greater than 3 frames) showed no such drop in performance, although results were still dependent on color (better for red) and increased with increasing SOA. These findings are consistent with a 2-stage model of visual working memory, where encoding of the first target disrupts attention to (and temporal binding of) the second target. We suggest that this disruption occurs within a certain time (≈ 0.5 s) after the first target, during which period salient distractors are as likely as the second target to enter working memory.
Etheric bimesogens and the twist-bend nematic phase (2015)

Despite the relationship between molecular structure and the occurrence of the twist-bend nematic phase being partially understood, very little is known about how these relationships are manifested for ether-linked bimesogens. In this article, we report several novel ether-linked bimesogens that exhibit the NTB phase and explore how the thermal properties of these materials are largely governed by the angle between the two aromatic, carbocyclic or rigid cyclic units.
A DWDM/SCM self-healing architecture for broad-band subscriber networks (2003)

A high-capacity dense wavelength-division multiplexing/subcarrier multiplexing (DWDM/SCM) network based on a self-healing star-bus-ring architecture (SBRA) is proposed and demonstrated. This architecture has a star subnet on the upper level to be a high-capacity infrastructure for the network, several bus subnets on the middle level to offer broad-band channels for multiwavelength signals, and many ring subnets on the lower level to serve a number of nodes. We design remote nodes and bidirectional wavelength add-drop multiplexers (WADMs) by using simple optical switches to reconfigure the network under link failure. We further employ M-quadrature amplitude modulation (M-QAM) and frequency shift-keyed (FSK) signals for downstream and upstream channels, respectively. The SBRA ensures an optical-beat-interference-free (OBI-free) and high-reliability optical network. Finally, we set up an experimental network to demonstrate the feasibility of the proposed architecture.
Lower Temperature Electrolytic Reduction of CO[sub 2] to O[sub 2] and CO with High-Conductivity Solid Oxide Bilayer Electrolytes (2005)

Ceramic oxygen generators (COGs) with a bilayer-electrolyte (erbia-stabilized bismuth oxide/samaria-doped ceria) architecture were developed to produce pure oxygen from at lower temperature (below ) for potential use in NASA's Mars exploration mission. Major factors that influence oxygen generation include the oxygen-ion conductivity of the solid-oxide electrolyte, applied current, operating temperature, and fuel utilization ( ratio). The COG voltage power losses were due to internal resistance and electrode polarization. Higher temperatures resulted in higher oxygen generation rates due to reduced cell resistance. However, lowering the COG operating temperature is very important and the bilayer COGs showed promise for operation below , thus reducing the required power consumption, expanding ancillary material selection, decreasing fabrication cost, and potentially extending mission time.
Lamellar phase separation in a centrifugal field. A method for measuring interbilayer forces (2010)

We present a novel method for measuring interbilayer forces in lamellar liquid crystals of amphiphile–water systems. In a centrifuge the gravitational effect is easily strong enough to produce clearly observable concentration gradients. During the experiment the concentration profile in the test-tube is monitored using NMR imaging of the deuterium quadrupole splitting in the lamellar phase, by temporarily transferring the sample into a NMR spectrometer. We also present a theoretical analysis of the experiment, where interactions dominate over entropy of mixing effects. For a system at sedimentation equilibrium one obtains a direct measurement of the interbilayer force, or equivalently chemical potential of the components over a substantial concentration range. It requires long times to obtain equilibrium in the centrifuge but very useful information about equilibrium and dynamic parameters is also obtained through an analysis of the sedimentation process. Experiments were performed on samples of a dilute lamellar phase of the non-ionic surfactant C10E3. After a few days of centrifugation a consistent concentration pattern was observed. At the bottom of the sample there appears a pure water-phase. The concentration profiles stabilize after a long centrifugation time. If they are related to the phase boundary the different profiles superimpose. This observation is consistent with the theory and the observation allows for a determination of how the chemical potentials vary with composition. The observed profiles are consistent with a dominating undulation force with a bilayer bending rigidity of 4.8–5.1 kT.
Effects of Commonly Used Hemostatic Agents on the Porcine Collecting System (2007)

FloSeal, Tisseel, CoSeal, and BioGlue, if injected directly into the porcine collecting system, can result in significant obstruction that does not resolve over a 5-day period. Until there are clinical data to the contrary, we believe that when using one of these hemostatic agents in association with a tubeless percutaneous procedure, a retrograde occlusion balloon catheter should be considered to prevent inadvertent injection of these materials into the collecting system.
Anthrylenes with end-capping diphenyl moiety for blue organic light-emitting diodes (2010)

A series of new blue emitting materials; 9,10-diotolylanthracene (1), 2-tert-butyl-9,10-diphenylanthracene (2), 10,10'-diphenyl-9,9'-bianthracene (3), and 1,4-bis(10-phenylanthracen-9-yl)benzene (4) were designed and synthesized for organic light-emitting diodes (OLEDs). In order to test the electroluminescent properties of 1-4, those were used as the host materials for the blue dopant materials, PFVtPh and PCVtPh. Using 2 as host material for PFVtPh blue dopant material, the device shows high EL efficiencies with 5.63 cd/A, 4.13 lm/W, and 4.49 % (3.92 cd/A, 1.50 lm/W, and 3.04 % at 20 mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) with the CIE coordinate of (0.152, 0.154).
Microtubules form by progressively faster tubulin accretion, not by nucleation–elongation (2021)

Microtubules are dynamic polymers that play fundamental roles in all eukaryotes. Despite their importance, how new microtubules form is poorly understood. Textbooks have focused on variations of a nucleation-elongation mechanism in which monomers rapidly equilibrate with an unstable oligomer (nucleus) that limits the rate of polymer formation; once formed, the polymer then elongates efficiently from this nucleus by monomer addition. Such models faithfully describe actin assembly, but they fail to account for how more complex polymers like hollow microtubules assemble. Here, we articulate a new model for microtubule formation that has three key features: (1) microtubules initiate via rectangular, sheet-like structures that grow faster the larger they become; (2) the dominant pathway proceeds via accretion, the stepwise addition of longitudinal or lateral layers; and (3) a "straightening penalty" to account for the energetic cost of tubulin's curved-to-straight conformational transition. This model can quantitatively fit experimental assembly data, providing new insights into biochemical determinants and assembly pathways for microtubule nucleation.
Magneto-optic contact for application in an amplifying waveguide optical isolator (2006)

Abstract: We present the development of a metal-semiconductor contact for a TM-mode amplifying waveguide optical isolator and show that it is a compromise between good (magneto-)optical performance and good electrical behavior. An optical isolator is indispensable in a telecom link to protect the laser sources against back-reflected light. A waveguide version of this component is highly desirable as it would decrease the packaging cost – hence the overall cost – of a laser diode module largely. An approach that is getting a lot of attention in recent years [1-2] involves the use of a ferromagnetic metal as the source of the non-reciprocal effect. In an optical waveguide covered with a transversely magnetized ferromagnetic metal film close to the guiding region, the magneto-optic (MO) Kerr effect induces a non-reciprocal shift of the complex effective index of the guided mode. In other words, the modal loss is dependent on the propagation direction of the light. If the guiding core consists of amplifying layers, electrical biasing decreases the internal loss of the waveguide. The result is a device which, being transparent in the forward while providing loss in the opposite direction, is isolating. As the isolator basically has the same structure as the laser it is to be integrated with, monolithic integration is straightforward. In the simplest configuration, illustrated in figure 1 and operating for TM-polarized light, the ferromagnetic metal acts as the electrical contact for the underlying semiconductor optical amplifier. Therefore, an important issue that needs to be solved is the development
ChemInform Abstract: The Thionium/N‐Acyliminium Ion Cyclization Cascade as a Strategy for the Synthesis of Azapolycyclic Ring Systems. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fast-Dissolving Tablet (2016)

This Glossary of Terms Related to Pharmaceutics is needed by practitioners in the field of pharmaceutics as this field fulfills an important and crucial role, different from the roles of other scientific disciplines involved in the drugmaking process. The glossary contains 168 definitions used in pharmaceutics. These are related to various aspects of this discipline, such as: (1) physicochemical characterization of pharmaceutical preparations and the active ingredients they contain; (2) unit operations used in the practice of pharmaceutics; (3) terms related to the various dosage forms; (4) terms related to the various modes and routes of drug delivery; (5) terms used in pharmacokinetics and biopharmaceutics in general; and additional miscellaneous terms. The field of pharmaceutics itself is of a multidisciplinary nature as its practitioners come from a variety of disciplines, such as chemistry or various biological sciences, thus a glossary containing authoritative definitions would be useful for them. The terms used in pharmaceutics are rarely covered by existing glossaries, and in the cases they are, their definitions are often inappropriate for the field of pharmaceutics and require new or modified definitions to better fit the new context.
Energy-aware video storage and retrieval in server environments (2011)

As the popularity of video streaming and sharing over the Internet grows, energy consumption in video server environments increases as well. This paper discusses how energy consumption is a critical concern for video servers and can limit their throughput. We investigate the energy consumption of storage components (disks) in video servers and propose two ways to reduce it for better throughput. First, we organize data on disks in a way that allows easier access by exploiting the inherent properties of video access patterns and giving priority to more important video data. Second, the prioritized ordering of video data allows the server to retrieve only the data required to meet quality of service agreements in an energy efficient way. Therefore, the video quality delivered to clients may be scaled in order to service more concurrent requests and/or reduce energy consumption. Results show that our strategies can increase the number of clients served by as much as 114% when compared to conventional approaches while also meeting constraints on video quality and energy consumption.
Supplementary Data from Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma (2023)

&lt;p&gt;Supplemental Figure 4&lt;/p&gt;
Design and evaluation of a cellular rectifier system with distributed control (1999)

This paper presents the design and experimental evaluation of a six-cell 6 kW cellular (parallel) rectifier system which operates at nearly unity power factor. The cellular rectifier system implements both distributed load sharing and distributed ripple cancellation, eliminating the need for any centralized control. The implemented system mitigates some of the major drawbacks of its single-converter counterpart and achieves performance levels that cannot be achieved with an equivalent single converter.
Carbon Based Resistive Memory (2009)

We propose carbon as new resistive memory material for non-volatile memories and compare three allotropes of carbon, namely carbon nanotubes, graphene-like conductive carbon and insulating carbon for their possible application as resistance-change material in high density non-volatile memories. Repetitive high-speed switching and the potential for multi-level programming have been successfully demonstrated.