gebhart/patrepeval huggingface dataset:
A History of Early Southeast Asia: Maritime Trade and Societal Development, 100–1500 (2010)

Chapter 1: Trade and Statecraft in Early Southeast Asia Chapter 2: Early International Maritime Trade and Cultural Networking in the Southeast Asia Region, ca. 100-500 Chapter 3: Competition on the East Coast of the Mainland: Early Champa and Vietnam Political Economies Chapter 4: The Foundations of Indonesian Polity: Srivijaya and Java to the Early Tenth Century Chapter 5: Structural Change in the Javanese Community, ca. 900-1300 Chapter 6: The Temple-Based Mainland Political Economies of Angkor Cambodia and Pagan Burma, ca. 889-1300 Chapter 7: Transitions in the Southeast Asian Mainland Commercial Realm, ca. 900-1500 Chapter 8: Maritime Trade and Community Development in Fourteenth- and Fifteenth-Century Java Chapter 9: Upstream and Downstream Unification and the Changing Sense of Community in Southeast Asia's Fifteenth-Century Maritime Port-Polities Chapter 10: Maritime Trade and State Development, ca. 1250-1500 References
Adaptive rate matching assignment for multiplexed services in UMTS (2005)

In UMTS W-CDMA systems, multiplexed services such as voice, data, and video may be offered simultaneously on one physical connection. Several issues such as the error rate requirement for each service. algorithmic complexity, hardware limitations, and performance of the overall system must be considered. In this paper, we investigate the radio resource allocation issues under Rayleigh fading conditions and present link-level performance for multiplexed services on the reverse-link of a UMTS W-CDMA system. Specifically, we present an adaptive algorithm for selecting rate matching parameters that satisfies the quality of service requirements for all simultaneous services. This selection is crucial since different services naturally have different underlying frame error rate (FER) requirements. From simulation results, it is seen that the adaptive algorithm can achieve the error rates required for multiplexed services of varying data rates and types (e.g. speech, video, and data services). In addition. it is observed that the proposed algorithm requires only a few adjustments for convergence.
Monoclonal antibodies from combinatorial libraries (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMonoclonal antibodies from combinatorial librariesDennis R. BurtonCite this: Acc. Chem. Res. 1993, 26, 8, 405–411Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ar00032a003https://doi.org/10.1021/ar00032a003research-articleACS PublicationsRequest reuse permissionsArticle Views173Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A high power-handling RF MEMS tunable capacitor using quadruple series capacitor structure (2010)

This paper presents an RF MEMS tunable capacitor that achieves excellent power-handling property with relatively low actuation voltage. The tunable capacitor consists of two fixed MIM (Metal-Insulator-Metal) capacitors and two MEMS capacitor elements, all connected in series. This quadruple series capacitor (QSC) structure enables to reduce the actuation voltage without sacrificing the power-handling capability, since the MIM capacitor reduces the RF voltage amplitude applied to the MEMS capacitors. Measured result demonstrates +36dBm hot-switching at 85C with 21V pull-in voltage.
A 5291‐ppi organic light‐emitting diode display using field‐effect transistors including a c‐axis aligned crystalline oxide semiconductor (2019)

Abstract C‐axis‐aligned crystalline‐oxide semiconductor field‐effect transistor (CAAC‐OS FET) can be scaled down to a width and a length of 60 nm. We fabricated an organic light‐emitting diode (OLED) display with more than 5000 ppi, which is required in virtual reality (VR) display applications, using CAAC‐OS FETs as the backplane.
An Overview of Wide Bandgap SiC Sensor and Electronics Development at NASA Glenn Research Center (2007)

A brief overview is presented of the sensors and electronics development work ongoing at NASA Glenn Research Center which is intended to meet the needs of future aerospace applications. Three major technology areas are discussed: 1) high temperature SiC electronics, 2) SiC gas sensor technology development, and 3) packaging of harsh environment devices. Highlights of this work include world-record operation of SiC electronic devices including 500{degree sign}C JFET transistor operation with excellent properties, atomically flat SiC gas sensors integrated with an on-chip temperature detector/heater, and operation of a packaged AC amplifier. A description of the state-of-the-art is given for each topic. It is concluded that significant progress has been made and that given recent advancements the development of high temperature smart sensors is envisioned.
Developing a comprehensive, culturally sensitive conceptual framework of health domains in Singapore (2018)

The increasing focus of healthcare systems worldwide on long-term care highlights the need for culturally sensitive Health-Related Quality of Life instruments to accurately capture perceived health of various populations. Such instruments require a contextualized conceptual framework of health domains, which is lacking in some socio-cultural contexts. We developed a comprehensive and culturally sensitive conceptual framework of health domains relevant to the Singaporean population. We recruited Singaporeans/ permanent residents, English/ Chinese-speaking, with/ without chronic illnesses to participate in focus group discussions (FGDs) and in-depth interviews (IDIs). We elicited health areas participants perceived to be important for them to be happy and satisfied with life. To encourage spontaneous emergence of themes, we did not specify any aspect beyond the broad domains of Physical, Mental, and Social health so as not to limit the emergence of new themes. Themes from the transcripts were distilled through open coding (two independent coders), then classified into more abstract domains (each transcript coded independently by two coders from a pool of six coders). From October 2013 to August 2014, 121 members of the general public participated in 18 FGDs and 13 IDIs (44.6% males, mean age: 53.3 years 77% Chinese, 9% Malay, 12% Indian, 63% with chronic illness) while 13 healthcare workers participated as patient-proxies in three FGDs. Thematic analysis identified 27 domains. The 15 physical domains included physical appearance, energy, physical fitness, and health and resistance to illness. The nine mental domains included emotions, self-esteem, and personal freedom. The three social domains were social contact, social relationships, and social roles. This conceptual framework reflected physical, mental, and social dimensions of well-being, suggesting that the Singapore population's views on health support the World Health Organization's definition of health as "a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity".
Intra-Inter Prediction for Versatile Video Coding Using a Residual Convolutional Neural Network (2022)

This paper presents a convolutional neural network (CNN) based solution for inter prediction in Versatile Video Coding (VVC). Our approach aims at improving the motion-compensated prediction signal of inter blocks with a residual CNN that incorporates spatial and temporal reference samples, i.e., intra-inter prediction. It is motivated by two considerations. Firstly, incorporating intra reference samples has the potential to improve the prediction signal by adapting it to the reconstructed signal in its immediate vicinity. Secondly, neural network-based methods offer a higher degree of signal adaptivity than conventional signal processing methods. The proposed network is integrated as a post-processing module for inter predicted blocks in VVC. Experimental results show that average bit rate savings of 3.2% to 4.0% can be achieved for the random access configuration.
New Polyethylene Macroinitiators and Their Subsequent Grafting by Atom Transfer Radical Polymerization (2008)

A semicrystalline polyethylene (PE) macroinitiator was prepared by copolymerizing ethylene and an inititating monomer (5-norbornen-2-yl-2'-bromo-2'-methyl propanoate) (3) using [N-(2,6-diisopropylphenyl)-2-(2,6-diisopropylphenylimino)isobutanamidato]-Ni(eta1-CH2Ph)(PMe3) (1) and Ni(COD)2 (bis(1,5-cyclooctadiene)-nickel) (2). Although 3 decomposes Ni(COD)2, if the initiating species (1/2) are exposed to ethylene for a period of time, t1, and then 3 is introduced for another period of time, t2, the polymerization takes place in a controlled manner. Variations in temperature, pressure, and [3] afford a great deal of control over the composition and architecture of the PE macroinitiator. Subsequent grafting with methyl methacrylate (MMA) yields PE-graft-PMMA with narrow polydispersities and increasing PMMA content at longer reaction times. Because the products are semicrystalline materials with high melting points, they are anticipated to function as blend compatibilizers for linear polyethylene.
Rituximab in the treatment of acquired factor VIII inhibitors (2002)

Autoantibodies against factor VIII (FVIII) are rare but can cause life-threatening bleeding requiring costly factor replacement and prolonged immunosuppression. We report 4 consecutively treated patients whose acquired FVIII inhibitors responded rapidly to immunosuppressive regimens that included rituximab, a monoclonal antibody against CD20(+) B cells. Three patients had spontaneously occurring inhibitors. The fourth, a patient with mild hemophilia A, developed both an autoantibody and an alloantibody following recombinant FVIII treatment. Pretreatment FVIII activities ranged from less than 1% to 4% and inhibitor titers from 5 to 60 Bethesda units (BU). One patient with polymyalgia rheumatica who developed the inhibitor while receiving prednisone responded to single agent rituximab. The hemophilia patient had rapid resolution of the autoantibody, whereas the alloantibody persisted for months. Responses continue off treatment from more than 7 to more than 12 months. This report adds to the growing evidence that rituximab has efficacy in immune disorders resulting from autoantibody formation.
Practical Olefin Metathesis in Protic Media under an Air Atmosphere (2003)

Abstract The discovery that efficient olefin metathesis reactions involving previously challenging terminal olefin substrates are possible using novel and readily available catalyst systems in non‐distilled, non‐degassed protic media in air is reported.
Critical Role for Histone Deacetylase 6 (HDAC6) in the Regulation of IL-6, and the JAK/STA3 Signaling Cascade in Macrophages (2012)

Abstract Abstract 1039 Background Histone Deacetylases (HDACs) have divergent effects over the production of anti- and pro-inflammatory cytokines in Antigen Presenting Cells (APCs). We have previously shown that modulation of specific HDACs can alter the immunogenicity of APCs, either to an activating or tolerogenic phenotype. We recently identified HDAC6 to positively regulate IL-10 production. However, the participation of this HDAC in other immune related cellular processes remains unknown. In this work we are presenting evidence of the important role of HDAC6 in the regulation of IL-6 via activation of the JAK/STAT3 pathway. Methods Stable knockdown clones of HDAC6 (KDHDAC6) and Non-target (NT) cells were generated in RAW264.7 murine macrophages using lentiviral shRNA for HDAC6 or non-target (NT) respectively. Two KDHADC6 and two NT clones were treated with LPS or untreated and then analyzed by microarray using the Affymetrix GeneChip Mouse 430 2.0. Significantly down- or up-regulated genes were analyzed by their ontology distribution and selected genes were validated by quantitative real-time RT-PCR, ELISA, or immunoblots. Additionally, changes in the expression of these selected genes were tested in cells treated with selective HDAC6 inhibitors. Results 1542 genes were down-regulated and 775 up-regulated in KDHDAC6 cells. Their ontology distribution revealed significant changes in immune-related (632) and apoptosis/cell cycle control (47) genes. Importantly, IL-6 was one of the most highly down-regulated genes in KDHDAC6 cells. Therefore, we next analyzed the relevance of these findings by studying the tolerogenic JAK/STAT3 signaling pathway which is known to be activated by IL-6 and critical in the final outcome of APCs in response to stimuli. We observed a complete abrogation in the phosphorylation of JAK2 and STAT3 proteins in KDHDAC6 cells in response to LPS, which was reverted when these cells were treated with exogenous IL-6. Conclusions These results demonstrate the requirement of HDAC6 in the production of IL-6 in response to LPS, and therefore positions this deacetylase as an important regulator of the JAK/STAT3 pathway. These findings provide insight into the molecular mechanisms controlling the immunogenicity of APCs, supporting the use of HDAC6 inhibitors to enhance immune activation. Disclosures: No relevant conflicts of interest to declare.
Thread selection according to power characteristics during context switching on compute nodes (2023)

Methods, apparatus, and products are disclosed for thread selection during context switching on a plurality of compute nodes that includes: executing, by a compute node, an application using a plurality of threads of execution, including executing one or more of the threads of execution; selecting, by the compute node from a plurality of available threads of execution for the application, a next thread of execution in dependence upon power characteristics for each of the available threads; determining, by the compute node, whether criteria for a thread context switch are satisfied; and performing, by the compute node, the thread context switch if the criteria for a thread context switch are satisfied, including executing the next thread of execution.
Theory and Practice: Bulk Synthesis of C3B and its H2‐ and Li‐Storage Capacity (2015)

Abstract Previous theoretical studies of C 3 B have suggested that boron‐doped graphite is a promising H 2 ‐ and Li‐storage material, with large maximum capacities. These characteristics could lead to exciting applications as a lightweight H 2 ‐storage material for automotive engines and as an anode in a new generation of batteries. However, for these applications to be realized a synthetic route to bulk C 3 B must be developed. Here we show the thermolysis of a single‐source precursor (1,3‐(BBr 2 ) 2 C 6 H 4 ) to produce graphitic C 3 B, thus allowing the characteristics of this elusive material to be tested for the first time. C 3 B was found to be compositionally uniform but turbostratically disordered. Contrary to theoretical expectations, the H 2 ‐ and Li‐storage capacities are lower than anticipated, results that can partially be explained by the disordered nature of the material. This work suggests that to model the properties of graphitic materials more realistically, the possibility of disorder must be considered.
A Transformational Characterization of Equivalent Bayesian Network Structures (2013)

We present a simple characterization of equivalent Bayesian network structures based on local transformations. The significance of the characterization is twofold. First, we are able to easily prove several new invariant properties of theoretical interest for equivalent structures. Second, we use the characterization to derive an efficient algorithm that identifies all of the compelled edges in a structure. Compelled edge identification is of particular importance for learning Bayesian network structures from data because these edges indicate causal relationships when certain assumptions hold.
Absolute Minimum Deviation Controller for Multi-Level Flying Capacitor Direct Energy Transfer Converters (2020)

This paper introduces a dual-mode controller for multi-level flying capacitor (ML-FC) converters that provides theoretically minimum possible voltage deviation (absolute minimum), seamless mode transitions, and flying capacitor size reduction. These advantages are obtained by introducing a switching state that is not utilized during regular converter operation and the development of a simple capacitor peak/valley current matching technique. The effectiveness of the controller is verified with a 3.3 V, 15 W, 400 kHz frequency (800 kHz ripple frequency) three-level flying capacitor buck converter prototype.
Computers Learn to Listen, and Some Talk Back (2010)

Smarter Than You Think: Articles in this series will examine the recent advances in artificial intelligence and robotics and their potential impact on society.
Cross-correlation waveform mode: A critical review (2012)

Earth-reflected Global Navigation Satellite System (GNSS) signals have become an attractive tool for remote sensing. Recently it has been proposed as an alternative to the conventional altimetry to estimate the surface height However GNSS-R altimetry offers lower bandwidths and signals power compared to radar altimeters. This implies a poorer altimetry precision, accuracy and resolution per pulse.Also the altimetry precision will be impacted by the impact of the thermal, and speckle noise mainly. This paper gives a critical review of the cross-correlation waveform model.
Biopharmaceutical characterisation of a low‐dose (75 mg) controlled‐release aspirin formulation (1993)

The release of aspirin from a 75 mg controlled-release formulation, designed to inhibit maximally thromboxane A2 production while sparing stimulated prostacyclin biosynthesis, was characterised in healthy subjects. The calculated in vivo release rate of aspirin matched the design goal of approximately 10 mg h(-1). The C(max) of aspirin associated with the controlled-release formulation was lowered 15-fold relative to a solution formulation of the same dose. The bioavailability of aspirin (based on salicylate concentrations) from the controlled-release formulation was approximately 90% relative to the solution, and drug release was not affected by co-administration of a standard breakfast.
Telomerase inhibitors in cancer therapy: current status and future directions. (2003)

The ends of chromosomes (telomeres) are subject to progressive shortening in normal somatic cells, leading ultimately to irreversible growth arrest. In contrast, telomeres in all cancer cells are stabilized in length and effectively immortalized by the enzyme telomerase, which catalyzes the synthesis of telomeric DNA repeats. Several strategies have been devised for the inhibition of telomerase in the hope that this will result in anticancer effects. The principal approaches of catalytic inhibitors, antisense to the template, and folding of the DNA substrate, are reviewed and critically evaluated for their potential in anticancer therapy.
Table S2 from Human CD4<sup>+</sup> T Cells Specific for Merkel Cell Polyomavirus Localize to Merkel Cell Carcinomas and Target a Required Oncogenic Domain (2023)

&lt;p&gt;TCR sequences of MCPyV-WED-specific CD4 T cell clones&lt;/p&gt;
Active lasing from organic colloidal photonic crystals (2013)

This Highlight provides a brief review of recent progress in the field of colloidal crystals (CCs) combined with functional organic materials for active lasers. Colloidal microparticles have the intrinsic capability to form self-organized 3D ordered structures of microparticles, so-called CCs. From a technological perspective, it is of prime importance to fabricate CCs with photonic band gaps (PBGs) in a visible range. When a light-emitting dye is embedded in the CCs, optical excitation causes the laser emission by the PBG effect. Interestingly, such laser emission can be controlled by utilizing the functional controllability of organic materials. This article covers the background of research into CCs as photonic crystals, and highlights intriguing precedents of active organic CC lasers in response to external stimuli.
Pharmacology of GABAB receptors N.G. BOWERY (2001)

Metabotropic, or indirectly coupled, receptors are activated by a variety of neurotransmitters or paracrine hormones in the body and are responsible for mediating the actions of more than 70 per cent of the therapeutic agents which are currently in clinical use. These receptors depend on relatively few types of G-protein to link them to their effector mechanisms. Thus, it is the unique structure and conformation of individual receptors that provides the speciﬁc and individual characteristics of ligand action. In many cases the receptor is expressed in cell membranes simply as a monomer after transcription of the protein in the endoplasmic reticulum. In some instances the receptor is expressed as a functional unit by combination of two molecules of the entire receptor linked to form a homodimer. Up to 3 years ago there was no evidence for any functional receptors that comprised two forms of the complete receptor with distinct molecular structures coupled together. But then the unique conformation of the functional GABAB receptor(s) was revealed showing that it exists as a heterodimer (White et al., 1998; Kaupmann et al., 1998a; Jones et al., 1998; Kuner et al., 1999; Ng et al., 1999). This followed the original cloning of the receptor in 1997 by Kaupmann and colleagues. However, soon after the structure was announced it became apparent that the single individual receptor subunit is not normally expressed in the plasma membrane but remains in the endoplasmic reticulum (see Couve et al., 1998). Initial thoughts were focused on the possibility of an unknown trafﬁcking protein ‘RAMP’ (receptor activity modifying protein) being required to transport the receptor protein to the external membrane (cf. McLatchie et al., 1998). For detailed information about the structure of the GABAB receptor see Chapter 11.