gebhart/patrepeval huggingface dataset:
Structural Basis for Potent Cross-Neutralizing Human Monoclonal Antibody Protection against Lethal Human and Zoonotic Severe Acute Respiratory Syndrome Coronavirus Challenge (2020)

Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002, and detailed phylogenetic and epidemiological analyses have suggested that it originated from animals. The spike (S) glycoprotein has been identified as a major component of protective immunity, and 23 different amino acid changes were noted during the expanding epidemic. Using a panel of SARS-CoV recombinants bearing the S glycoproteins from isolates representing the zoonotic and human early, middle, and late phases of the epidemic, we identified 23 monoclonal antibodies (MAbs) with neutralizing activity against one or multiple SARS-CoV spike variants and determined the presence of at least six distinct neutralizing profiles in the SARS-CoV S glycoprotein. Four of these MAbs showed cross-neutralizing activity against all human and zoonotic S variants in vitro, and at least three of these were mapped in distinct epitopes using escape mutants, structure analyses, and competition assays. These three MAbs (S109.8, S227.14, and S230.15) were tested for use in passive vaccination studies using lethal SARS-CoV challenge models for young and senescent mice with four different homologous and heterologous SARS-CoV S variants. Both S227.14 and S230.15 completely protected young and old mice from weight loss and virus replication in the lungs for all viruses tested, while S109.8 completely protected mice from weight loss and clinical signs in the presence of viral titers. We conclude that a single human MAb can confer broad protection against lethal challenge with multiple zoonotic and human SARS-CoV isolates, and we identify a robust cocktail formulation that targets distinct epitopes and minimizes the likely generation of escape mutants.
Veredelung nachwachsender Rohstoffe durch Selektivoxidation mit Goldkatalysatoren (2010)

Abstract Die Gold‐katalysierte Selektivoxidation von Aldehyden und Alkoholen zu den korrespondierenden Carbonsäuren kann für die Funktionalisierung verschiedener Substanzen auf Basis nachwachsender Rohstoffe, z. B. Kohlenhydrate oder Fettalkoholethoxylate, in Zukunft große Bedeutung erlangen. Bei der Kohlenhydratoxidation weisen Goldkatalysatoren eine sehr hohe Aktivität sowie eine exzellente Selektivität und Langzeitstabilität auf und erlauben somit eine hocheffiziente Herstellung verschiedenster Aldonsäuren. Auch bei der Selektivoxidation von Ethoxylaten zeigen Goldkatalysatoren, dass diese universell, mit guter Aktivität und sehr guter Selektivität zu den entsprechenden Ethercarbonsäuren umgesetzt können.
Preparation and characterization by electrospray mass spectrometry of cationic metalloporphyrin DNA cleavers (1996)

Une serie de metalloporphyrines cationiques a activite nuclease a ete preparee et caracterisee par spectrometrie de masse en electrospray. Ces precurseurs porphyriniques fonctionnalises sont d'excellents agents de coupure de l'ADN qui peuvent etre lies a un oligonucleotide ou, comme cela est decrit, a Hoechst 33258, un colorant capable de reconnaitre le petit sillon de l'ADN.
Authorship Identification with Modality Specific Meta Features - Notebook for PAN at CLEF 2011. (2011)

Abstract This paper presents the approach used in the PAN ’11 authorship identification competition. Our method extracts meta features from several independently generated clustering solutions from the training set. Each clustering solution uses a disjoint set of features that represent a specific linguistic modality. The different clustering solutions encode similarities in writing styles of authors across specific dimensions. The final classifier is trained with a combination of the meta features with first level features. Our approach has outperformed a more syntactic oriented state-of-the-art method on web forum data. We achieved moderately successful results on this PAN competition, with better results on the test set with a smaller number of authors. However, considering that our system was not fine tuned for the PAN evaluation data we found our results very encouraging. 1
Nanoparticle Silver Released into Water from Commercially Available Sock Fabrics (2008)

Manufacturers of clothing articles employ nanosilver (n-Ag) as an antimicrobial agent, but the environmental impacts of n-Ag release from commercial products are unknown. The quantity and form of the nanomaterials released from consumer products should be determined to assess the environmental risks of nanotechnology. This paper investigates silver released from commercial clothing (socks) into water, and its fate in wastewater treatment plants (WWTPs). Six types of socks contained up to a maximum of 1360 µg-Ag/g-sock and leached as much as 650 µg of silver in 500 mL of distilled water. Microscopy conducted on sock material and wash water revealed the presence of silver particles from 10 to 500 nm in diameter. Physical separation and ion selective electrode (ISE) analyses suggest that both colloidal and ionic silver leach from the socks. Variable leaching rates among sock types suggests that the sock manufacturing process may control the release of silver. The adsorption of the leached silver to WWTP biomass was used to develop a model which predicts that a typical wastewater treatment facility could treat a high concentration of influent silver. However, the high silver concentration may limit the disposal of the biosolids as agricultural fertilizer.
ChemInform Abstract: Efficient Enantioselective Hydrosilylation of Ketones Catalyzed by Air Stable Copper Fluoride—Phosphine Complexes. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nucleotide and Polynucleotides (2012)

Abstract Review: 65 refs.
Human polyomavirus, JC virus, and progressive multifocal leukoencephalopathy (2005)

Abstract Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease of the central nervous system (CNS) resulting from the lytic infection of oligodendrocytes by a human polyomavirus, JC virus (JCV). This disease develops mostly in patients with underlying immunosuppressive conditions including AIDS, Hodgkin’s lymphoma, lymphoproliferative diseases and those undergoing antineoplastic therapy (Berger and Concha 1995; Berger and Major 1999; Berger 2000; Berger et al. 2001; Major et al. 1992). In addition, in a small number of cases, PML was also found to affect individuals with no underlying disease (Berger and Concha 1995; Major et al. 1992).
Total Synthesis of Brevisamide (2009)

The second total synthesis of Brevisamide, a marine cyclic ether alkaloid from Karenia brevis, is reported. This streamlined synthesis proceeds in 21 steps, 14 steps longest linear sequence, in 5.2% overall yield and features a key SmI(2) reductive cyclization step to access the tetrasubstituted pyran core.
The role of peri-aortic fat in aortic atherosclerosis (2009)

Introduction: Prophylactic implantation of a cardioverter/ defibrillator (ICD) has been shown to reduce mortality in patients with chronic myocardial infarction (CMI) and an increased risk for life threatening ventricular arrhythmia (VA). The use of ICDs in this large patient population is still limited by high costs and possible adverse events including inappropriate discharges and progression of heart failure. VA is related to infarct size and seems to be related to infarct morphology. Contrast enhanced cardiovascular magnetic resonance imaging (ceCMR) can detect and quantify myocardial fibrosis in the setting of CMI and might therefore be a valuable tool for a more accurate risk stratification in this setting. Hypothesis: ceCMR can identify the subgroup developing VA in patients with prophylactic ICD implantation following MADIT criteria. Methods: We prospectively enrolled 52 patients (49 males, age 69 10 years) with CMI and clinical indication for ICD therapy following MADIT criteria. Prior to implantation (36 78 days) patients were investigated on a 1.5 T clinical scanner (Siemens Avanto , Germany) to assess left ventricular function (LVEF), LV end-diastolic volume (LVEDV) and LV mass (sequence parameters: GRE SSFP, matrix 256 192, short axis stack; full LV coverage, no gap; slice thickness 6 mm). For quantitative assessment of infarct morphology late gadolinium enhancement (LGE) was performed including measurement of total and relative infarct mass (related to LV mass) and the degree of transmurality (DT) as defined by the percentage of transmurality in each scar. (sequence parameters: inversion recovery gradient echo; matrix 256 148, imaging 10 min after 0.2 g/kg gadolinium DTPA; slice orientation equal to SSFP). MRI images were analysed using dedicated software (MASS , Medis, Netherlands). LGE was defined as myocardial areas with signal intensity above the average plus 5 SD of the remote myocardium. After implantation, patients were followed up including ICD readout after 3 and than every 6 months for a mean of 945 344 days. ICD data were evaluated by an experienced electrophysiologist. Primary endpoint was the occurrence of an appropriate discharge (DC), antitachycard pacing (ATP) or death from cardiac cause. Results: The endpoint occurred in 10 patients (3 DC, 6 ATP, 1 death). These patients had a higher relative infarct mass (28 7% vs. 22 11%, p = 0.03) as well as high degree of transmurality (64 22% vs. 44 25%, p = 0.05). Their LVEF (29 8% vs. 30 4%, p = 0.75), LV mass (148 29 g vs. 154 42 g, p = 0.60), LVEDV (270 133 ml vs. 275 83 ml, p = 0.90) or total infarct mass (43 19 g vs. 37 21 g, p = 0.43) were however not significant from the group with no events. In a cox proportional hazards regression model including LVEF, LVEDV, LV mass, DT and age, only degree of transmurality and relative infarct mass emerged as independent predictors of the primary end point (p = 0.009).
The Acceptor and Site Specificity of α3-Fucosyltransferase V (2000)

We report here on in vitro acceptor and site specificity of recombinant alpha3-fucosyltransferase V (Fuc-TV) with 40 oligosaccharide acceptors. Galbeta1-4GlcNAc (LN) and GalNAcbeta1-4GlcNAc (LDN) reacted rapidly; Galbeta1-3GlcNAc (LNB) reacted moderately, and GlcNAcbeta1-4GlcNAc (N, N'-diacetyl-chitobiose) reacted slowly yet distinctly. In neutral and terminally alpha3-sialylated polylactosamines of i-type, the reducing end LN unit reacted rapidly and the distal (sialyl)LN group very slowly; the midchain LNs revealed intermediate reactivities. The data suggest that a distal LN neighbor enhances but a proximal LN neighbor reduces the reactivity of the midchain LNs. This implies that Fuc-TV may bind preferably the tetrasaccharide sequence Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAc for transfer at the underlined monosaccharide. Terminal alpha3-sialylation of i-type polylactosamines almost doubled the reactivities of the LN units at all positions of the chains. We conclude that, in comparison with human Fuc-TIV and Fuc-TIX, Fuc-TV reacted with a highly distinct site specificity with i-type polylactosamines. The Fuc-TV reactivity of free LNB resembled that of LNBbeta1-3'R of a polylactosamine, contrasting strongly with the dissimilarity of the reactivities of the analogous pair of LN and LNbeta1-3'R. This observation supports the notion that LN and LNB may be functionally bound at distinct sites on Fuc-TV surface. Our data show that Fuc-TV worked well with a very wide range of LN-glycans, showing weak reactivity only with distal (sialyl)LN units of i-type polylactosamines, biantennary N-glycans, and I branches of polylactosamines.
Effects of Secretin on the Normal and Pathologicalβ-Cell* (1988)

Secretin is a gastrointestinal hormone that stimulates insulin secretion and enhances the insulin response to glucose. The mechanism by which secretin acts on the beta-cell has not been extensively studied. The plasma insulin responses to secretin (2 U/kg), expressed as the percent increase relative to basal plasma insulin concentrations, were similar in normal (n = 23) and obese subjects with normal glucose tolerance (n = 12), but were decreased in obese subjects with abnormal glucose tolerance (n = 11). The insulin response to secretin was directly proportional to the basal insulin concentration in these three groups. The effects of secretin on beta-cell function was not altered by propranolol (n = 6), atropine (n = 8), or surgical vagotomy (n = 10). Patients with single islet cell tumors secreting insulin (n = 18) had no plasma insulin response to secretin, whereas patients with noninsulin-secreting pancreatic tumors (gastrinomas; n = 6) and patients in whom single insulinomas had been removed (n = 7) responded normally. Two adult patients with multiple B-cell adenomas and hyperplasia (not associated with multiple endocrine neoplasia type I) hyperresponded to secretin, whereas patients with multiple endocrine neoplasia, type I, without hyperinsulinism responded normally. One patient with nesidioblastosis had no response to secretin, indicating that the pathophysiology of this entity is distinct from that of other forms of islet hyperplasia. These data suggest that secretin stimulates beta-cells directly rather than through cholinergic, adrenergic, or vagal peptidergic neural mechanisms. In addition, the ability to respond to secretin appears to be lost in patients with single insulinomas and nesidioblastosis, but not in those with multiple B-cell adenomas and hyperplasia. The lack of a plasma insulin response in patients with single insulinomas and the high normal or exaggerated response in patients with multiple B-cell adenomas and hyperplasia may prove useful in differentiating these entities.
Quantum size effect in magnetic tunnel junctions with single-crystal ultrathin electrodes (2004)

Control of coherent electron transports in spintronic devices is an essential issue to realize highly functional spin-devices such as spin-dependent resonant-tunneling transistors. The spin dependent resonant tunneling via the quantum-well states in the electrode gives us many clues to understand and to control transport property in magnetic tunnel junctions (MTJs). To observe the quantum-well oscillations in TMR effect, we prepared the magnetic tunnel junctions with single-crystal ultrathin electrode or insertion layers. The MTJs with an ultrathin Fe [001] electrode shows the oscillation of TMR ratio as a function of the biasing voltage. In the case of an ultrathin Cu [001] layer inserted between a Co electrode and Al/sub 2/O/sub 3/ barrier layer, we found large oscillations of TMR with respect to the thickness of the Cu electrode. These results clearly show a feasibility of the coherent spintronic devices using metallic systems.
New Pyranocoumarins Isolated from Calophyllum lanigerum and Calophyllum teysmannii (1996)

ADVERTISEMENT RETURN TO ISSUEPREVErratumNew Pyranocoumarins Isolated from Calophyllum lanigerum and Calophyllum teysmanniiTawnya C. McKee, Richard W. Fuller, Conni D. Covington, John H. Cardellina, Robert J. Gulakowski, Benjamin L. Krepps, James B. McMahon, and Michael R. BoydCite this: J. Nat. Prod. 1996, 59, 11, 1108Publication Date (Web):November 22, 1996Publication History Published online22 November 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/np960677thttps://doi.org/10.1021/np960677tcorrectionACS PublicationsCopyright © 1996 American Chemical Society and American Society of Pharmacognosy. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views375Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (8 KB) Get e-Alertsclose Get e-Alerts
Control of a Flexible Manipulator With Noncollocated Feedback: Time-Domain Passivity Approach (2004)

A new method to control a flexible manipulator with noncollocated feedback is proposed. We introduce a method to implement the time-domain passivity-control approach to a flexible manipulator with noncollocated feedback, which could not be treated with the previous time-domain passivity-control framework due to a possible active transfer function from the input to the noncollocated output. The proposed method is simulated with a single-link flexible manipulator, and a good control performance is obtained.
Pyrrolo[2,3-c]pyridines as Imaging Agents for Neurofibrilary Tangles (2016)

ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXTPyrrolo[2,3-c]pyridines as Imaging Agents for Neurofibrilary TanglesBenjamin Blass*View Author Information Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, United States*Tel: 215-707-1085. E-mail: [email protected]Cite this: ACS Med. Chem. Lett. 2016, 7, 5, 444–446Publication Date (Web):March 14, 2016Publication History Received20 February 2016Published online14 March 2016Published inissue 12 May 2016https://pubs.acs.org/doi/10.1021/acsmedchemlett.6b00078https://doi.org/10.1021/acsmedchemlett.6b00078editorialACS PublicationsCopyright © 2016 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1045Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (298 KB) Get e-AlertscloseSUBJECTS:Alkyls,Central nervous system,Group 17 compounds,Nervous system diseases,Peptides and proteins Get e-Alerts
MuLan: A Joint Embedding of Music Audio and Natural Language (2022)

Music tagging and content-based retrieval systems have traditionally been constructed using pre-defined ontologies covering a rigid set of music attributes or text queries. This paper presents MuLan: a first attempt at a new generation of acoustic models that link music audio directly to unconstrained natural language music descriptions. MuLan takes the form of a two-tower, joint audio-text embedding model trained using 44 million music recordings (370K hours) and weakly-associated, free-form text annotations. Through its compatibility with a wide range of music genres and text styles (including conventional music tags), the resulting audio-text representation subsumes existing ontologies while graduating to true zero-shot functionalities. We demonstrate the versatility of the MuLan embeddings with a range of experiments including transfer learning, zero-shot music tagging, language understanding in the music domain, and cross-modal retrieval applications.
Localization of amidating enzymes (PAM) in rat gastrointestinal tract. (1993)

We studied the distribution of the two enzymes involved in post-translational C-terminal alpha-amidation of regulatory peptides in rat digestive tract, using immunocytochemical methods and in situ hybridization techniques. The enzymes were located in most of the fibers and neurons of the myenteric and submucous plexus throughout the entire digestive tract and in endocrine cells of the stomach and colon. Staining of reverse-face serial sections demonstrated that the enzymes in endocrine cells of the stomach co-localized with gastrin in the bottom of the gastric glands. Some gastrin-immunoreactive cells near the neck of the gland were negative for PAM, suggesting that amidation takes place only in the more mature cells. In the colon all cells immunoreactive for glucagon and GLP1 were also positive for peptidylglycine alpha-hydroxylating monooxygenase (PHM) but not for peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). The absence of immunoreactivity for the amidating enzymes in endocrine cells of the small intestine, known to produce C-terminally amidated peptides, suggests the existence of other amidating enzymes.
Association between cancer chemotherapy and canine distemper virus, canine parvovirus, and rabies virus antibody titers in tumor-bearing dogs (2001)

Results suggest that established immunity to CDV, CPV, and rabies virus from previous vaccination is not significantly compromised by standard chemotherapy used to treat tumor-bearing dogs.
Troubleshooting blackbox SDN control software with minimal causal sequences (2014)

Software bugs are inevitable in software-defined networking control software, and troubleshooting is a tedious, time-consuming task. In this paper we discuss how to improve control software troubleshooting by presenting a technique for automatically identifying a minimal sequence of inputs responsible for triggering a given bug, without making assumptions about the language or instrumentation of the software under test. We apply our technique to five open source SDN control platforms---Floodlight, NOX, POX, Pyretic, ONOS---and illustrate how the minimal causal sequences our system found aided the troubleshooting process.