gebhart/patrepeval huggingface dataset:
Random Forests versus Neural Networks - What's Best for Camera\n Localization? (2016)

This work addresses the task of camera localization in a known 3D scene given\na single input RGB image. State-of-the-art approaches accomplish this in two\nsteps: firstly, regressing for every pixel in the image its 3D scene coordinate\nand subsequently, using these coordinates to estimate the final 6D camera pose\nvia RANSAC. To solve the first step, Random Forests (RFs) are typically used.\nOn the other hand, Neural Networks (NNs) reign in many dense regression tasks,\nbut are not test-time efficient. We ask the question: which of the two is best\nfor camera localization? To address this, we make two method contributions: (1)\na test-time efficient NN architecture which we term a ForestNet that is derived\nand initialized from a RF, and (2) a new fully-differentiable robust averaging\ntechnique for regression ensembles which can be trained end-to-end with a NN.\nOur experimental findings show that for scene coordinate regression,\ntraditional NN architectures are superior to test-time efficient RFs and\nForestNets, however, this does not translate to final 6D camera pose accuracy\nwhere RFs and ForestNets perform slightly better. To summarize, our best\nmethod, a ForestNet with a robust average, which has an equivalent fast and\nlightweight RF, improves over the state-of-the-art for camera localization on\nthe 7-Scenes dataset. While this work focuses on scene coordinate regression\nfor camera localization, our innovations may also be applied to other\ncontinuous regression tasks.\n
Crystal structure of elongation factor P from Thermus thermophilus HB8 (2004)

Translation elongation factor P (EF-P) stimulates ribosomal peptidyltransferase activity. EF-P is conserved in bacteria and is essential for cell viability. Eukarya and Archaea have an EF-P homologue, eukaryotic initiation factor 5A (eIF-5A). In the present study, we determined the crystal structure of EF-P from Thermus thermophilus HB8 at a 1.65-A resolution. EF-P consists of three beta-barrel domains (I, II, and III), whereas eIF-5A has only two domains (N and C domains). Domain I of EF-P is topologically the same as the N domain of eIF-5A. On the other hand, EF-P domains II and III share the same topology as that of the eIF-5A C domain, indicating that domains II and III arose by duplication. Intriguingly, the N-terminal half of domain II and the C-terminal half of domain III of EF-P have sequence homologies to the N- and C-terminal halves, respectively, of the eIF-5A C domain. The three domains of EF-P are arranged in an "L" shape, with 65- and 53-A-long arms at an angle of 95 degrees, which is reminiscent of tRNA. Furthermore, most of the EF-P protein surface is negatively charged. Therefore, EF-P mimics the tRNA shape but uses domain topologies different from those of the known tRNA-mimicry translation factors. Domain I of EF-P has a conserved positive charge at its tip, like the eIF-5A N domain.
Optofluidic tuning of quantum cascade lasers (2006)

The authors demonstrate the compatibility of quantum cascade lasers (QCLs) with elastomer-based microfluidics and the tuning of QCLs using liquids with different refractive indices. They look to increasing sensitivity to liquids with ultra high-Q photonic crystal based QCLs.
PEGYLATED INTERFERON–RIBAVIRIN AND INTERFERON/RIBAVIRIN THERAPY FOR CHRONIC HEPATITIS C IN A PRIVATE PRACTICE GASTROENTEROLOGY GROUP (2004)

Purpose: Multiple randomized trials have shown the efficacy of Inter-feron/Ribavirin (I/R) and Pegylated Interferon/Ribavirin (PI/R) therapies in patients with chronic Hepatitis C (Hep C). There are few studies assessing the effectiveness of therapy in a “real-world” private practice setting. Methods: Retrospective chart review was utilized to assess the effi-cacy/tolerability of Hep C therapy and the baseline features of treated patients. Results: 670 patients were seen in consultation for “Hep C” during the study period; 590 (88.1%) were viremic. Demographics of combination therapy patients: 61% male, mean age 45 +/- 7 yrs, 18% African American, 33% cirrhotic, 21% genotype 2 or 3. The degree of fibrosis and elevated liver enzymes were predictive of patients receiving treatment; age, race and genotype were not. During the study, 168 patients received 196 courses of Hep C therapy. 29 of these patients received Interferon Monotherapy (IM) (excluded from effectiveness results). 139 patients received 164 courses of Hep C therapy with I/R (98 courses) or PI/R (66 courses). 25 of these patients had failed IM in the past. Sustained virologic response (SVR) and sustained biochemical response (SBR) were achieved in 48% and 41% respectively in patients treated with PI/R (Table).Table: Response to Combination TherapyFor patients treated with PI/R, medication doses were decreased in 27% of cases. Caucasian race, genotype non - 1 and lower BMI were associated with a SVR; age, cirrhosis and gender were not. SVR with PI/R based on genotype 1 or 4 vs. 2 or 3 was 29% and 77% respectively. Conclusions: Combination therapy for Hep C was generally safe and moderately well tolerated in a large group of private practice Hep C patients. While the sustained virologic response rates are below those in large randomized trials, this may be explained by the higher proportion of African-American patients, patients with increased BMI and patients who failed previous therapy. Future health policy decision regarding Hep C therapy should be based on data from effectiveness studies rather than efficacy trials. Additional studies must define the effectiveness of therapy in “real-world” patients cared for by community-based physicians.
(Quasi‐)Racemic X‐ray Structures of Glycosylated and Non‐Glycosylated Forms of the Chemokine Ser‐CCL1 Prepared by Total Chemical Synthesis (2014)

Abstract Our goal was to obtain the X‐ray crystal structure of the glycosylated chemokine Ser‐CCL1. Glycoproteins can be hard to crystallize because of the heterogeneity of the oligosaccharide (glycan) moiety. We used glycosylated Ser‐CCL1 that had been prepared by total chemical synthesis as a homogeneous compound containing an N‐linked asialo biantennary nonasaccharide glycan moiety of defined covalent structure. Facile crystal formation occurred from a quasi‐racemic mixture consisting of glycosylated L ‐protein and non‐glycosylated‐ D ‐protein, while no crystals were obtained from the glycosylated L ‐protein alone. The structure was solved at a resolution of 2.6–2.1 Å. However, the glycan moiety was disordered: only the N‐linked GlcNAc sugar was well‐defined in the electron density map. A racemic mixture of the protein enantiomers L ‐Ser‐CCL1 and D ‐Ser‐CCL1 was also crystallized, and the structure of the true racemate was solved at a resolution of 2.7–2.15 Å. Superimposition of the structures of the protein moieties of L ‐Ser‐CCL1 and glycosylated‐ L ‐Ser‐CCL1 revealed there was no significant alteration of the protein structure by N‐glycosylation.
Supplementary Figure S1 from Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck (2023)

&lt;p&gt;Supplementary Figure S1. Overview of the identified mutations in UNC7 HNSCC cell line by whole exome sequencing.&lt;/p&gt;
Horizontal p-i-n High-Speed Ge Waveguide Detector on Large Cross-section SOI Waveguide (2010)

We report a novel high-speed Ge photodetector on a large cross-section SOI waveguide platform. The device is butt-coupled with waveguide using a horizontal p-i-n junction configuration to enable high-speed operation. A very compact Ge detector with an active area of only 0.8 × 10 µm2, greater than 32GHz optical bandwidth at -1V of reverse bias, and a responsivity of 1.1A/W is demonstrated.
Extraction de la matrice-S des composants optiques monomodes (2003)

Conférence JNOG 2003, Valence (France)
Transparent performance monitoring of RZ-DQPSK systems employing delay-tap sampling (2007)

Feature Issue on Transmission in Optically Transparent Core NetworksThe emerging transparent optical networks, employing spectrally efficient modulation formats, require new methods for supervision of signal quality in order to maintain control over the transmission in all-optical domains. Optical performance monitoring of optical signal-to-noise ratio, chromatic dispersion, and polarization-mode dispersion in return-to-zero differential quadrature phase-shift keying signals is demonstrated using asynchronous delay-tap sampling and pattern recognition algorithms. Precise estimation of parameters over a broad range of impairment levels and good degradation isolation is shown by means of numerical simulation.
Characterization of Biaryl Torsional Energetics and its Treatment in OPLS All-Atom Force Fields (2013)

The frequency of biaryl substructures in a database of approved oral drugs has been analyzed. This led to designation of 20 prototypical biaryls plus 10 arylpyridinones for parametrization in the OPLS all-atom force fields. Bond stretching, angle-bending, and torsional parameters were developed to reproduce the MP2 geometries and torsional energy profiles. The transferability of the new parameters was tested through their application to three additional biaryls. The torsional energetics for the 33 biaryl molecules are analyzed and factors leading to preferences for planar and nonplanar geometries are identified. For liquid biphenyl, the computed density and heat of vaporization at the boiling point (255 °C) are also reported.
Cooling System Design (2007)

No AccessInjection Mold Design EngineeringAug 2007Cooling System DesignDavid O. KazmerDavid O. Kazmerhttps://doi.org/10.3139/9783446434196.009SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF ShareFacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2007 Pages: 199-232Print ISBN: 978-3-446-41266-8eISBN: 978-3-446-43419-6 Copyright & Permissions© 2007 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
QoS-based User Scheduling for Multiuser MIMO Systems (2005)

Next generation wireless networks are being developed to support a wide variety of data services with a broad range of quality of service (QoS) requirements. We consider the problem of downlink scheduling wherein a base station (BS) with multiple antennas serves a multiuser system. Assuming that different users can be served by the transmitter antennas at each slot, we allocate each BS antenna to users based on certain priority functions. We study a QoS-based allocation scheme, wherein the priority functions capture the user QoS demands quantified in terms of throughput and delay. We attempt to identify scheduling schemes that provide a good trade-off between (i) higher system capacity by exploiting inherent multiuser diversity, (ii) fairness among users based on their instantaneous channel conditions relative to average channel conditions, and (iii) tolerable latency requirements specified by the user applications. Simulation results evaluate the performance of the above allocation scheme and show that multiple antennas and delay-aware scheduling rules can be efficiently used to provide QoS at little expense of throughput.
Address-Identifier Mapping System for scalable routing (2009)

The main architectural problem with the current inter-domain routing model is the overloading of IP addresses due to their use for identification, location, and forwarding. This makes it hard to support the need for multi-homing, traffic engineering, and mobility while maintaining address hierarchy that is essential for scalable routing. Thus, there is a need to separate identifiers from locators. In this paper we identify architectural and protocol changes in addressing and routing needed to provide major improvements in scalability. We design a corresponding protocol solution (Address-Identifier Mapping System — AIMS) based on separation of identification and addressing, and a mechanism for mapping ID to address.
Labral reconstruction with ITB autograft normalizes hip contact pressure after antero‐superior labral resection: an in‐vitro biomechanical analysis (2014)

Labral reconstruction with Illiotibial Band (ITB) autograft tissue was recently described as a surgical alternative to labral debridement for insufficient or degenerative hip labrums. However, the biomechanical advantages of this technique are still under investigation. The purpose of the present study was to characterize the in-vitro contact pressures in the acetabulum in the normal intact state, anterosuperior labral resection, and labral reconstruction with ITB autograft. Our null hypothesis is that there will be no significant differences between the groups.
Palmitylation of neuromodulin (GAP-43) is not required for phosphorylation by protein kinase C. (1992)

Neuromodulin (also designated GAP-43, B-50, and F-1) is a prominent protein kinase C substrate attached to the membranes of neuronal growth cones during development and to presynaptic membranes in discrete subsets of adult synapses. In this study, we have examined the relationship between the attachment of neuromodulin to membranes and its phosphorylation by protein kinase C. To address this issue, we have compared wild-type and mutant neuromodulins expressed in cells that normally lack the protein. Wild-type neuromodulin expressed in Chinese hamster ovary cells was associated with membranes, incorporated [3H]palmitic acid, and was phosphorylated in response to phorbol ester treatment. Substitution of serine 41, the in vitro protein kinase C site, abolished the phorbol ester response, indicating that serine 41 serves as the sole protein kinase C phosphorylation site in vivo. Substitution of the putative fatty acylation sites, cysteines 3 and 4, abolished membrane association as well as [3H]palmitic acid labeling of neuromodulin. Fatty acylation therefore appears to serve as the mechanism for anchoring neuromodulin to membranes. Surprisingly, the soluble cysteine substitution mutant was phosphorylated by protein kinase C at a rate indistinguishable from that of the wild-type protein. Therefore, membrane association may not be required for the phosphorylation of neuromodulin by protein kinase C.
Use of a Mixture of n-Dodecyl-β-d-maltoside and Sodium Dodecyl Sulfate in Poly(dimethylsiloxane) Microchips To Suppress Adhesion and Promote Separation of Proteins (2007)

Dynamic modification of poly(dimethylsiloxane) channels using a mixture of n-dodecyl-beta-D-maltoside (DDM) and sodium dodecyl sulfate (SDS) is able to suppress analyte adsorption and control electroosmotic flow (EOF). In this mixed surfactant system, the nonionic surfactant DDM functions as a surface blocking reagent, whereas the anionic surfactant SDS introduces negative charges to the channel walls. Changing the DDM/SDS mixing ratio tunes the surface charge density and the strength of EOF. Using 0.1% (w/v) DDM and 0.03% (w/v) SDS, Alexa Fluor 647 labeled streptavidin can be analyzed according to the charges added by the fluorophores. Protein molecules with different numbers of fluorophores are well resolved. DDM and SDS also form negatively charged mixed micelles, which act as a separation medium. The low critical micellar concentration of DDM/SDS mixed micelles also allows the use of SDS at a nondenaturing concentration, which enables the analysis of proteins in their native state. The immunocomplex between a membrane protein, beta2 adrenergic receptor, and anti-FLAG antibody has been fully separated using 0.1% (w/v) DDM and 0.03% (w/v) SDS. We have also analyzed the composition of light-harvesting protein-chromophore complexes in cyanobacteria.
Three-dimensional optical lattice clock with bosonicSr88atoms (2010)

We present detailed analyses of our recent experiment on the three-dimensional (3D) optical lattice clock with bosonic $^{88}\mathrm{Sr}$ atoms in which the collisional frequency shift was suppressed by applying a single-occupancy lattice. Frequency shifts in magnetically induced spectroscopy on the ${}^{1}{S}_{0}--{}^{3}{P}_{0}$ clock transition ($\ensuremath{\lambda}=698$ nm) of $^{88}\mathrm{Sr}$ were experimentally investigated by referencing a one-dimensional (1D) lattice clock based on spin-polarized $^{87}\mathrm{Sr}$ atoms. We discuss that the clock stability is limited by the current laser stability as well as the experimental sequence of the clock operation, which may be improved to ${\ensuremath{\sigma}}_{y}(\ensuremath{\tau})=2\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}16}/\sqrt{\ensuremath{\tau}}$ by optimizing the cycle time of the clock operation.
Selective Oxidation of Methane to Methanol via In Situ H2O2 Synthesis (2023)

The selective oxidation of methane to methanol, using H<sub>2</sub>O<sub>2</sub> generated in situ from the elements, has been investigated using a series of ZSM-5-supported AuPd catalysts of varying elemental composition, prepared via a deposition precipitation protocol. The alloying of Pd with Au was found to offer significantly improved efficacy, compared to that observed over monometallic analogues. Complementary studies into catalytic performance toward the direct synthesis and subsequent degradation of H<sub>2</sub>O<sub>2</sub>, under idealized conditions, indicate that methane oxidation efficacy is not directly related to H<sub>2</sub>O<sub>2</sub> production rates, and it is considered that the known ability of Au to promote the release of reactive oxygen species is the underlying cause for the improved performance of the bimetallic catalysts.
Regulation of intercellular adhesion molecule‐1 expression by retinoic acid: Analysis of the 5′ regulatory region of the gene (1994)

Human intercellular adhesion molecule-1 (ICAM-1), a specific ligand for the lymphocyte-function-associated antigen-1, plays an important role in immune responses. ICAM-1 expression is regulated by various proinflammatory cytokines, by PMA, and by retinoic acid. In this study, we have investigated the mechanisms of transcriptional control involved in the stimulation of ICAM-1 gene expression by retinoic acid in SK-N-SH cells. Northern-blot analysis demonstrated that ICAM-1 mRNA is maximally induced at 24 hr, suggesting that it is not an early-response gene with respect to retinoic-acid responsiveness, whereas the retinoic acid receptor-beta mRNA level was maximal 12 hr following retinoic acid treatment. To analyze the 5'-regulatory region of the ICAM-1 gene, an EcoRI/SaII fragment spanning the first 1.3 kb upstream of the translational start site was used to direct the expression of a linked luciferase reporter gene in transient transfection assays in SK-N-SH cells. A 24-hr treatment of transfected cells with 10 microM retinoic acid resulted in a 10- to 13-fold increase in luciferase activity compared with untreated cells. Deletion mutant analysis revealed that a region located between -393 and -176 bp from the translational start site is critical for retinoic acid stimulation of luciferase activity. This region harbors a consensus sequence for a retinoic-acid-responsive element (RARE) homologous to the element found upstream of the alcohol dehydrogenase-3 gene. Co-transfection of expression vectors encoding the retinoic acid receptor-alpha, -beta, or -gamma, with reporter plasmids harboring the putative RARE, confirmed that the ICAM-1 gene is regulated by retinoic acid in a retinoic acid receptor-dependent fashion.
Solvent-Free Dynamic Nuclear Polarization of Amorphous and Crystalline ortho-Terphenyl (2013)

Dynamic nuclear polarization (DNP) of amorphous and crystalline ortho-terphenyl (OTP) in the absence of glass forming agents is presented in order to gauge the feasibility of applying DNP to pharmaceutical solid-state nuclear magnetic resonance experiments and to study the effect of intermolecular structure, or lack thereof, on the DNP enhancement. By way of (1)H-(13)C cross-polarization, we obtained a DNP enhancement (ε) of 58 for 95% deuterated OTP in the amorphous state using the biradical bis-TEMPO terephthalate (bTtereph) and ε of 36 in the crystalline state. Measurements of the (1)H T1 and electron paramagnetic resonance experiments showed the crystallization process led to phase separation of the polarization agent, creating an inhomogeneous distribution of radicals within the sample. Consequently, the effective radical concentration was decreased in the bulk OTP phase, and long-range (1)H-(1)H spin diffusion was the main polarization propagation mechanism. Preliminary DNP experiments with the glass-forming anti-inflammation drug, indomethacin, showed promising results, and further studies are underway to prepare DNP samples using pharmaceutical techniques.
Modeling flow setup time for controller placement in SDN: Evaluation for dynamic flows (2017)

Software-Defined Networking (SDN) controllers are network entities that act as strategic control points in an SDN network. Controller placement studies mostly aim at optimizing network performance in terms of control latency, reliability and resilience, given network characteristics that are static. Yet dynamic traffic conditions, if not adapted by the controller placement properly, may cause high end-to-end flow setup time. For reactive controllers, the end-to-end flow setup time of a flow implies the difference between sending time at the source and receiving time at the sink of the first packet in that flow. Therefore, end-to-end flow setup time indicates the amount of time needed to set up forwarding rules in all involved switches and acts as a primary concern in terms of service establishment of network operators. In this paper, we analyze the controller placement for dynamic traffic flows based on a combined controller placement model: controller locations and switch-to-controller assignments are simultaneously optimized for minimum average flow setup time with respect to different traffic conditions inside the network. Linearization method is applied to transform the problem into a Mixed Integer Programming (MIP) problem which can be solved optimally. Two derivatives are also presented for comparison, one optimizing only controller locations and the other optimizing only switch-to-controller assignments. Our simulations cover two real network topologies and we explain the effects of the models have on the flow setup time with respect to dynamic flows. For low flow densities, the controller placement that adapts to flows could reduce the average flow setup time by about 50% compared to the static placement. However, when densities are high, the need of changing controller placement to guarantee flow setup performance is marginal.
ChemInform Abstract: Bathochromic or Hypsochromic Effects via the Extension of Conjugation: A Study Stilbenoid Squaraines. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.