gebhart/patrepeval huggingface dataset:
Supplementary Figure 7C, D from Somatic Epigenetic Silencing of <i>RIPK3</i> Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma (2023)

&lt;p&gt;Expression of RIPK3 induced activation of MLKL and cell death, which was rescued by treatment with GSK'872. Transduction of M12 cells (C) and M22 cells (D) with lentivirus expressing shMLKL or shGFP and then selected for 72 h with puromycin. Stable cells expressing shMLKL or shGFP were then infected with WPI or WPI expressing RIPK3. Immunoblotting and cell viability were performed after 48 h to detect the activation of MLKL. Expression of RIPK3 induced necroptosis, which was rescued by MLKL knockdown.&lt;/p&gt;
Theory of normal-incidence absorption for the intersubband transition inn-type indirect-gap semiconductor quantum wells (1994)

We have studied systematically the normal-incidence-radiation absorption for the intersubband transition in the quantum well of n-type indirect-gap semiconductors. By a special choice of the coordinate system related to the sample growth direction, we have proposed a simple method to calculate the elements of the inverse effective-mass tensor. Using the concept of the invariance of the ellipsoidal constant-energy surface under coordinate transformations, the general expression for the absorption coefficient of the intersubband transition has been derived as a function of the sample growth direction. We have also investigated the maximal value of the normal-incidence radiation absorption, the optimal growth direction for quantum-well detectors, and the comparison between normal- and parallel-incidence-radiation absorptions. These are of great utility for designing and optimizing the quantum-well infrared detector for normally incident radiations.
The effects of ethnicity on disease patterns in 472 Orientals with systemic lupus erythematosus. (1998)

Ethnicity influenced disease manifestations at diagnosis in this cohort of Oriental patients with SLE. Renal or CNS involvement developed in previously unaffected patients up to 18 years after diagnosis, highlighting the need for continued vigilance in patients with lupus.
SCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure (2023)

Exclusion of the left atrial appendage to reduce thromboembolic risk related to atrial fibrillation was first performed surgically in 1949. Over the past 2 decades, the field of transcatheter endovascular left atrial appendage closure (LAAC) has rapidly expanded, with a myriad of devices approved or in clinical development. The number of LAAC procedures performed in the United States and worldwide has increased exponentially since the Food and Drug Administration approval of the WATCHMAN (Boston Scientific) device in 2015. The Society for Cardiovascular Angiography & Interventions (SCAI) has previously published statements in 2015 and 2016 providing societal overview of the technology and institutional and operator requirements for LAAC. Since then, results from several important clinical trials and registries have been published, technical expertise and clinical practice have matured over time, and the device and imaging technologies have evolved. Therefore, SCAI prioritized the development of an updated consensus statement to provide recommendations on contemporary, evidence-based best practices for transcatheter LAAC focusing on endovascular devices.
Dynamics, NOx and Flashback Characteristics of Confined Pre-Mixed Hydrogen Enriched Methane Flames (2007)

The operating regime of a gas turbine combustor is highly sensitive to fuel composition changes. In particular, the addition of hydrogen, a major constituent of syngas, has a major effect on flame behavior due to the higher burning rates associated with hydrogen. A laboratory scale pre-mixed test rig is constructed in order to study such effects. The fuel composition is incremented with increasing hydrogen starting from 100% methane. It is observed that increased RMS pressure levels and higher susceptibility to flashback occurs with increasing hydrogen volume fraction. Furthermore, hydrogen enrichment can cause an abrupt change in the dominant acoustic mode. Phase locked hydroxyl PLIF measurements have been performed with respect to the dominant acoustic instability limit cycle. These measurements are complemented with real time heat release, emissions and flashback measurements. Particular emphasis is put on time resolving the thermoacoustic instability induced flashback cycle of the wedgeshaped flame front and the temporal events associated with flashback.
Purine‐Based Inhibitors of Inositol‐1,4,5‐trisphosphate‐3‐kinase (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
Dynamic simulation and experimental validation of an upper extremity powered orthosis (2010)

The Wilmington Robotic Exoskeleton (WREX) is a passive upper limb orthosis powered by elastic bands, designed to assist children with weakness in their upper limbs. Patient studies with the WREX have determined that an external power source would enhance performance of the system. Two actuation schemes were considered: (i) motors in series with springs at the joints, called `Torsional' (ii) motors in series with gravity balancing elastic bands, called `In-line'. Dynamic models of these two motor placements were developed. Dynamic simulations, based on representative patient motion data, were performed. We observed that the torsional case with motors in series with springs at the joints required substantially less torque when compared to the in-line case with motors in series with gravity balancing springs. An experimental platform is being developed with this configuration and preliminary results are included.
Polymer‐bound cellulose phenylcarbamate derivatives as chiral stationary phases for enantioselective HPLC (2003)

Abstract Novel chiral stationary phases (CSP) have been prepared by coating the internal surface of monodisperse macroporous poly(2‐aminoethyl methacrylate‐ co ‐ethylene dimethacrylate) beads with dimethylphenylcarbamate derivatives of regenerated cellulose. The coating was achieved either by simple adsorption or by chemical bonding using a diisocyanate linker. Separation of enantiomers in normal‐phase HPLC mode was used to evaluate the enantioselectivity of all CSPs. The influence of the properties of the polymer support such as pore size, pore volume, and content of the amine functionalities, reaction and separation conditions such as weight ratio of modified cellulose selector to polymer beads, amount of diisocyanate crosslinker, and the composition of the mobile phase on chiral discrimination and chromatographic resolution were also systematically investigated. The CSPs prepared by chemical anchoring were more stable and a wider range of solvents including dichloromethane could be used for the separations. Compared to the coated‐type CSPs, the chemically bonded stationary phases enabled the enantioseparations of a larger number of racemates and exhibited enantioselectivity fully comparable to their counterparts prepared using porous silica as a support. However, the benefits of tailored macroporous polymer supports demonstrated earlier with brush‐type CSPs did not enhance the performance of the chiral stationary phases prepared from cellulose‐based selectors.
Open-content signal processing laboratories in connexions (2003)

Due to inherent factors such as a small and fragmented market and rapid hardware obsolescence, the conventional textbook is inadequate for DSP laboratory education. Freely available open-content materials that enable and promote both local customization and further development by a community of educators offers a fresh approach to lab text development that can surmount these barriers. We overview a joint effort under the aegis of the Connexions Project to develop a large pool of DSP lab modules sufficient to serve as the complete, stand-alone text for several types of DSP lab courses.
Abstract 2848: Combination of DNA methyltransferase and PARP inhibitors as a novel therapy strategy for poor prognosis acute myeloid leukemia (2015)

Abstract We present here strong preclinical data for a novel, mechanistically based, combinatorial approach to using DNA methyltransferase inhibitors (DNMTi’s), such as decitabine (DAC) and 5-Azacytidine (AzaC), with PARP inhibitors (PARPi’s) as a treatment strategy for acute myelogenous leukemias (AML). AzaC and DAC alone show efficacy in AML but combinatorial approaches will be required to maximize therapeutic responses. PARPi's have not been well studied as agents for these diseases. The mechanistic rationale for our approach is based upon: 1) data from our group and others showing DNMT's and PARP co-reside in DNA damage induced protein complexes; 2) the fact that AzaC and DAC trap DNMT's into DNA via their mechanism of action, led us to hypothesize that these drugs might also increase PARP trapping at DNA damage sites 3) the cytotoxicity of clinically available PARPi’s, and especially the most potent ones, appears to correlate with degree of trapping of PARP1 at DNA damage sites in chromatin. We first find that, indeed, in cultured human AML cells, the DNMTi's (10 to 20 nM DAC) and PARPi's (1 to 10 nM BMN 673) alone trap PARP into chromatin and this effect is enhanced when the drugs are combined. Concomitant with this, the combined doses, especially, strongly reduce double strand break (DSB) repair thereby increasing cytotoxic DNA damage. In association with these findings, in methylcellulose cloning assays of both cultured (N = 4) and primary AML cells (N = 9), a combination of the DNMTi's and PARPi's strongly decreased colony survival compared to each of the agents alone. Interestingly those cell lines and primary samples expressing poor prognostic FLT3/ITD (Fms-like tyrosine kinase 3 internal tandem duplication) mutations, were particularly sensitive to the combination treatment. Based on all the above results, we developed an in-vivo treatment model, using human FLT3/ITD-positive, MV411-luc xenografts in immunocompromised mice. As opposed to mock treatment, and treatment with AzaC or BMN673, alone, the combined drug treatment, over a 40 day treatment course, starkly and significantly decreases leukemia burden, as measured by luciferase imaging, peripheral blood blast counts and spleen weights. Our data suggest a novel use of both DNMTi's and PARPi's in a compelling therapeutic strategy for poor prognosis AML, that will be funded by Van Andel-SU2C for a clinical trial to be based at the University of Maryland. Citation Format: Nidal E. Muvarak, Carine Robert, Pratik K. Nagaria, Khadiza Chowdhury, Eun Yong Choi, Vu Duong, Ashkan Emadi, Maria R. Baer, Rena Lapidus, Stephen Baylin, Feyruz Rassool. Combination of DNA methyltransferase and PARP inhibitors as a novel therapy strategy for poor prognosis acute myeloid leukemia. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2848. doi:10.1158/1538-7445.AM2015-2848
User adaptive transcoding for video teleconferencing (2015)

The human visual system (HVS) cannot perceive spatial frequency components in an image that are above a certain limit, the value of which is affected by factors such as the viewing distance. This has been exploited to improve the video coding efficiency by first filtering out redundant frequency components and then doing conventional video encoding. To facilitate the deployment of this scheme, we propose to implement it in a network entity such as a Multipoint Control Unit (MCU). Specifically, by analyzing the video sent from a client, the MCU infers that client's viewing conditions, which are then used to adapt the encoding of the video destined to that client. The scheme is implemented in a real-world video teleconferencing system. Experimental results show that our approach can result in significant savings in bandwidth without affecting subjective video quality.
Don't get fooled: atrial and ventricular undersensing or atrial loss of capture? (2012)

Panel A displays an electrocardiogram recorded in a patient with a dual-chamber pacemaker. What is going on? Panel B gives the solution to the enigma. The fourth spike is …
ChemInform Abstract: Sequential Diastereoselective Addition and Palladium(II)‐Catalyzed Allylic Acetate Transposition of syn‐ and anti‐α‐Acetoxy‐β‐ silyl‐(E)‐hex‐4‐enoates with Achiral Acetals. Asymmetric Synthesis of Differentiated syn‐ and anti‐1,3‐Diol Synthons. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Wireless Mesh Networks (2007)

Wireless mesh networking is rapidly gaining in popularity with a variety of users: from municipalities to enterprises, from telecom service providers to public safety and military organizations. This increasing popularity is based on two basic facts: ease of deployment and increase in network capacity expressed in bandwidth per footage.
mcruRE-mcmNIcs BASED DELAMINATION GROWTH PREDICTION IN THE VERY SMALL PERIF'HERY ARRAY (VSPAm) PACKAGE (1998)

Interfaci.P delamination due to the presence of dissimilar material systems is one of the primary concerns in the fail-safe design of electronic packages. The mismatch in the coefficients of thermal expansion between the different layers can generate high interfacial stresses under thermal loads during fabrication, assembly, and/or fielduse conditiots. These stresses, if sufficiently large, can compromise the adhesive integrity of interfaces. The propagation of the resulting delaminations along such interfaces can degrade or completely destroy the functionality of the package. The focus of this study is to predict the potential for interfacial delamination propagation in current and future versions of a novel surface mountable, high YO Very Small Peripheral /may (VSPATM) package. The delamination growth prediction is based on the comparison of interfacial fracture parameters obtained from numerical simulations to appropriate critical values determined ewperimentally using controlled fracture toughness tests. Two-dimensional and three-dimensional numerical models were constructed of the VSPATM package with interfacial cracks embedded at critical locations. The energy release rate associated with interfacial fracture was determined by employing global energy balance and a crack closure technique. The fracture mode mixity was determined using a crack surface displacement method. A material parametric study was alii0 completed using the numerical models with pre-existing delaminations to identify material property trends that would lower the potential for failure. For a baseline materials suite, these available fracture pmuneters were compared with experimentally determined critical interl‘acial fracture toughness data to ascertain the possibility of delaminatior, growth. The fracture toughness of the interface of interest in this study was characterized using a test method that requires simple test specimen, fixture and loading geometries, and data reduction method.
Rapid fibrin plug formation within cutaneous ablative fractional CO2 laser lesions (2015)

The current study has demonstrated rapid fibrin plug formation after ablative fractional laser procedures. It was shown that the passage through laser created pathways is critically time dependent for in vivo exposures. In contrast, ex vivo exposures do not exhibit such time dependent passage capacity. In particular, drug, substance, and cell delivery studies for ablative fractional laser treatments should take early fibrin plug formation into consideration and further investigate the impact on transdermal delivery.
Role of Water in the Lyotropic Liquid Crystalline Mesophase of Lithium Salts and Non-ionic Surfactants (2021)

The lyotropic liquid crystalline (LLC) mesophase forms upon evaporation of water from aqueous solutions of LiX salts (X is Cl<sup>-</sup>, Br<sup>-</sup>, NO<sub>3</sub><sup>-</sup>, or SCN<sup>-</sup>) and a surfactant [C<sub>12</sub>H<sub>25</sub>(OCH<sub>2</sub>CH<sub>2</sub>)<sub>10</sub>OH, abbreviated as C<sub>12</sub>E<sub>10</sub>]. The LiX/C<sub>12</sub>E<sub>10</sub>/H<sub>2</sub>O aqueous solutions have been monitored (during evaporation of their excess water to obtain stable LLC mesophases) by gravimetric, spectroscopic, and conductivity measurements to elucidate the role of water in these mesophases. The water/salt molar ratio in stable mesophases changes from 1.5 to 8.0, depending on the counteranion of the salt and the ambient humidity of the laboratory. The LiX/C<sub>12</sub>E<sub>10</sub>/H<sub>2</sub>O LLC mesophases lose water at lower humidity levels and absorb water at higher humidity levels. The LiCl-containing mesophase holds as few as four structural water molecules per LiCl, whereas the LiNO<sub>3</sub> mesophase holds 1.5 waters per salt (least among those assessed). This ratio strongly depends on the atmospheric humidity level; the water/LiX mole ratio increases by 0.08 ± 0.01 H<sub>2</sub>O in the LLC mesophases per percent humidity unit. Surprisingly, the LLC mesophases are stable (no salt leaching) in broad humidity (10-85%) and salt/surfactant mole ratio (2-10 LiX/C<sub>12</sub>E<sub>10</sub>) ranges. Attenuated total reflectance Fourier transform infrared spectroscopic data show that the water molecules in the mesophase interact with salt species more strongly in the LiCl mesophase and more weakly in the case of the nitrate ion, which is evident by the shift of the O-H stretching band of water. The O-H stretching peak position in the mesophases decreases in the order ν<sub>LiCl</sub> > ν<sub>LiBr</sub> > ν<sub>LiSCN</sub> > ν<sub>LiNO<sub>3</sub></sub> and accords well with the H<sub>2</sub>O/LiX mole ratio. The conductivity of the LLC mesophase also responds to the amount of water as well as the nature of the counteranion (X<sup>-</sup>). The conductivity decreases in the order σ<sub>LiCl</sub> > σ<sub>LiBr</sub> > σ<sub>LiNO<sub>3</sub></sub> > σ<sub>LiSCN</sub> at low salt mole ratios and in the order σ<sub>LiBr</sub> > σ<sub>LiCl</sub> > σ<sub>LiNO<sub>3</sub></sub> > σ<sub>LiSCN</sub> at higher ratios due to structural changes in the mesophase.
Tuning aggregation-induced emission nanoparticle properties under thin film formation (2019)

The preparation of AIE nanoparticles under thin film formation controls their size and the associated fluorescent intensity, with the smaller nanoparticles significantly increasing brightness.
Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus MT:10398A>G (2023)

Abstract Mitochondrial (MT) dysfunction has been associated with several neurodegenerative diseases including Alzheimer’s disease (AD). While MT-copy number differences have been implicated in AD, the effect of MT heteroplasmy on AD has not been well characterized. Here, we analyzed over 1,800 whole genome sequencing data from four AD cohorts in seven different tissue types to determine the extent of MT heteroplasmy present. While MT-heteroplasmy was present throughout the entire MT genome for blood samples, we detected MT-heteroplasmy only within the MT control region for brain samples. We observed that an MT variant 10398A&gt;G (rs2853826) was significantly associated with overall MT-heteroplasmy in brain tissue while also being linked with the largest number of distinct disease phenotypes of all annotated MT variants in MitoMap . Using gene-expression data from our brain samples, our modeling discovered several gene networks involved in mitochondrial respiratory chain and Complex I function associated with 10398A&gt;G. The variant was also found to be an expression quantitative trait loci (eQTL) for the gene MT-ND3. We further characterized the effect of 10398A&gt;G by phenotyping a population of lymphoblastoid cell-lines (LCLs) with and without the variant allele. Examination of RNA sequence data from these LCLs reveal that 10398A&gt;G was an eQTL for MT-ND4. We also observed in LCLs that 10398A&gt;G was significantly associated with overall MT-heteroplasmy within the MT control region, confirming the initial findings observed in post-mortem brain tissue. These results provide novel evidence linking MT SNPs with MT heteroplasmy and open novel avenues for the investigation of pathomechanisms that are driven by this pleiotropic disease associated loci.
Supplementary table 1 from <i>S</i>-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase (2023)

&lt;p&gt;WB densitometry and statistical analyses&lt;/p&gt;
[Evaluation on left ventricular systolic synchronicity and cardiac function in patients with permanent cardiac pacing by real-time three-dimensional echocardiography]. (2010)

Real-time three-dimensional echocardiography can objectively and accurately evaluate left ventricular systolic synchronism and cardiac function in patients with permanent cardiac pacing and AAI mode is superior to DDD and VVI models.
DGEclust: differential expression analysis of clustered count data (2015)

We present a statistical methodology, DGEclust, for differential expression analysis of digital expression data. Our method treats differential expression as a form of clustering, thus unifying these two concepts. Furthermore, it simultaneously addresses the problem of how many clusters are supported by the data and uncertainty in parameter estimation. DGEclust successfully identifies differentially expressed genes under a number of different scenarios, maintaining a low error rate and an excellent control of its false discovery rate with reasonable computational requirements. It is formulated to perform particularly well on low-replicated data and be applicable to multi-group data. DGEclust is available at http://dvav.github.io/dgeclust/.
First-principles energy band calculation of Pr-doped ZrSiO<sub>4</sub> (2021)

The electronic structure of Pr-doped ZrSiO4 is calculated using modified Becke–Johnson potential plus on-site Coulomb interaction (MBJ + U). The minimum energy gap of ZrSiO4 calculated using the MBJ method is 5.8 eV, which is close to the experimental value. When a Pr atom replaced one of Zr atoms, strongly localized Pr 4f states appear in the forbidden gap of ZrSiO4. By considering the on-site Coulomb interaction in addition to the MBJ potential, the empty Pr 4f states appear about 2 eV above the valence band maximum of ZrSiO4. Compared with generalized gradient approximation (GGA), MBJ, and GGA + U approaches, MBJ + U better describes the position of empty Pr 4f states for Pr-yellow pigment.
Detecting Contradiction in Text by Using Lexical Mismatch and Structural Similarity. (2013)

Detecting contradicting statements is a crucial sub-problem for ltering textual entailment pairs. Given two text pairs T1 and T2 that are topically related, the task is to nd whether the two statements are in contrast to each other, or not. In many situations a mismatch in named entities or numerical expressions is a strong clue for a contradiction between T1 and T2. However, if the dependency parse trees are quite dierent, and the words of T1 and T2 cannot be aligned well, then this indicates that a lexical mismatch is not sucient to conclude contradiction of T1 and T2. We present a new method that assumes the higher the structural similarity of two sentences, the higher the chance that a con-tradiction on the word level indicates contradiction on the sentence level. We participated in two subtasks of RITE2 at NTCIR-10 which contain many contradicting statements in a real world setting. Our system became second place in the ExamBC subtask (formal run, ocial result), and rst place in the ExamSearch subtask (formal run, unocial re-sult). We show that our proposed method contributed to the improvement in both tasks.