gebhart/patrepeval huggingface dataset:
Distinct Cellular Mechanisms Underlie Smooth Muscle Turnover in Vascular Development and Repair (2017)

Extensive proliferation of immature smooth muscle cells in the primitive embryonic dorsal aorta establishes the long-lived lineages of smooth muscle cells that make up the wall of the adult aorta. A discrete population of smooth muscle cells forms in the embryo and is postnatally sustained at arterial branch sites. In response to arterial injuries, existing smooth muscle cells give rise to neointima, but on extensive damage, they are replaced by adventitial cells.
Ultrafast laser generated strain in granular and continuous FePt thin films (2018)

We employ ultrafast X-ray diffraction to compare the lattice dynamics of laser-excited continuous and granular FePt films on MgO (100) substrates. Contrary to recent results on free-standing granular films, we observe in both cases a pronounced and long-lasting out-of-plane expansion. We attribute this discrepancy to the in-plane expansion, which is suppressed by symmetry in continuous films. Granular films on substrates are less constrained and already show a reduced out-of-plane contraction. Via the Poisson effect, out-of-plane contractions drive in-plane expansion and vice versa. Consistently, the granular film exhibits a short-lived out-of-plane contraction driven by ultrafast demagnetization which is followed by a reduced and delayed expansion. From the acoustic reflections of the observed strain waves at the film-substrate interface, we extract a 13% reduction of the elastic constants in thin 10 nm FePt films compared to bulk-like samples.
Sludge Dewatering and Its Physical Properties (1975)

Discharging water‐treatment‐plant sludge into natural water courses is an unacceptable method of sludge disposal. The physical properties of sludge only add to the problem and increases the expense of tho complex process involved in rendering the sludge handleable. This article examines several methods of sludge dewatering and its ultimate disposal.
Large-signal response of high speed p-i-n photodetectors to short pulses with small spot sizes (2003)

Summary form only given. We simulated the behavior of a feasible photodetector: a 25 x 25 /spl mu/m p-i-n diode. To determine the spatio-temporal behavior, we monitored the voltage change across the photodiode in response to the incident pulse. For that, we used a dual-diode structure that was comprised of a p-i-n photodiode with a bulk intrinsic region integrated with a p-i(MQW)-n reflective electrooptical modulator diode on the bottom.
Results from Response Surface Methodology in the Study of Novel Temporary and Permanent Clay Stabilizers (2016)

Abstract The performance results from a systematic study of novel and contemporary clay stabilizers are provided. These interactions range from synergistic to antagonistic and are presented on a response surface with good correlation. Both organic and inorganic permanent and temporary clay stabilizers were studied. Some of these novel effective inhibitors have HIMS ratings lower than choline chloride. Various clay stabilizers are employed when stimulation techniques requiring aqueous based fluids are necessary in water sensitive formations. Typically, if swelling or migrating clays are present, temporary or permanent stabilizers are utilized. Low molecular weight temporary stabilizers, as a rule, perform only above a critical level concentration, but as the stabilizer's concentration diminishes in the fracturing fluid due to flowback, formation fluid displacement, or other mechanisms, the clay can swell, reducing porosity and permeability. Permanent stabilizers are generally higher molecular weight and can adhere to single or multiple clay platelets, thus dissolution of the stabilizer into the fluid is not favored, and the beneficial anti-swelling effect is of higher duration. This study was set up using Central Composite Design of Experiments. Performance testing was conducted using a low pressure Bariod fluid loss cell. A set concentration of unbenefited sodium bentonite was blended into water at a specific RPM and duration in the presence of the particular stabilizers, then placed in the cell, sealed, and pressure was applied. Finally leak off rates were measured. The slope of the leak off curve was calculated and plotted versus dosage. The slopes and response surfaces observed had excellent correlation. Additive effects and synergies were noted. The design of efficient temporary clay stabilizers can be directly linked to performance. Novel temporary clay stabilizers competitive with choline chloride in both performance and environmental profile should be welcomed in stimulation. The duration of the stabilization could also be studied using this test method since porous media experimentation is difficult to perform.
Central projections of vestibular afferents from the horizontal semicircular canal in the carpet shark Cephaloscyllium isabella (1983)

This study utilizes anterograde axonal transport of cobaltous-lysine and conventional silver-staining techniques to study the central projections of the horizontal semicircular canal branch of the VIII nerve within the vestibular nuclei of the carpet shark Cephaloscyllium isabella. Two major terminating axon fields were observed, one caudal and one rostral to the entrance of the VIII nerve, corresponding to the ventral vestibular nucleus and superior vestibular nucleus, respectively. Both fields appear to be located within the ventral portion of the nuclei indicating an apparent subdivision of the VIII nerve projections within the brainstem. The resolution of the sensitive cobalt tracer indicates the presence of both dendritic and pericellular termination of these primary afferent fibres. In the area immediately caudal to the entrance of the VIII nerve a number of labelled primary afferent fibres project to the ventral region of the intermediate nucleus. Other fibres follow the visceral sensory root VII and terminate proximal to the sulcus limitans of His within the dendritic field of the neurons of the nucleus magnocellularis. Some fibres turn ventromedially from the main group of the ascending fibres and terminate in the area of the inferior reticular formation.
Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin (2018)

We report an efficient synthesis of GDC-0810 on the basis of a sequence involving a highly stereoselective lithium tert-butoxide-mediated enolization-tosylation (≥95:5 E: Z) and a Pd-catalyzed Suzuki-Miyaura cross-coupling as key steps. Global deprotection, pyrrolidine salt formation, and final active pharmaceutical ingredient (API) form control/isolation produced GDC-0810 free acid in a 40% overall yield with >99.0% purity as ascertained by HPLC analysis.
Abstract 17215: Pacing Burden in Those Undergoing Permanent Pacemaker Implantation After TAVR With Latest Generation Valves (2018)

Background: Risk factors leading to heart block (HB) and need for permanent pacemaker (PPM) implantation post-TAVR using latest generation heart valves have been described. Yet, little is known regarding pacing burden following PPM implantation among such patients. Objective: We sought to determine follow-up RV pacing burden among those undergoing PPM for HB following TAVR. Methods: From July 2016 to July 2017, we reviewed procedural and 3-month follow-up data (including PPM interrogation data) from all patients undergoing implantation of Edwards Sapien 3® and Medtronic Evolut-R® valves at our institution and requiring implantation of a PPM due to HB secondary to the TAVR procedure. Results: Of 132 included patients who underwent TAVR with new generation valves, 25 (19%) required post-TAVR PPM implantation. Of 25 patients, 18 had available follow-up pacemaker data [Table]. Pacing burden post-PPM implantation of 29mm valves was significantly greater compared to non-29mm valves (40.2% vs. 5.4%, p = 0.02). Those with baseline conduction system disease (RBBB or LBBB) had greater pacing burdens, in particular when 29mm Evolut-R® self-expanding valves were deployed (n=3, RV pacing burden 63.3%). Extension of programmed AV delays produced significant reduction in RV pacing burden. Conclusion: In those undergoing TAVR with latest generation valves complicated by HB requiring PPM use, implantation of larger-sized valves (29 mm Evolut-R® in the present series), as well as baseline RBBB or LBBB results in increased follow-up RV pacing burden. This may be mitigated by adjustment of pacing parameters. Further work investigating long-term pacing burden and its consequences is needed to provide additional insight. Table: Demographics, baseline ECG characteristics, procedural characteristics, pacing mode, pacing parameters and follow-up RV pacing burden.
Structure of the hypothetical DUF1811-family protein GK0453 fromGeobacillus kaustophilusHTA426 (2013)

The crystal structure of a conserved hypothetical protein, GK0453, from Geobacillus kaustophilus has been determined to 2.2 Å resolution. The crystal belonged to space group P4(3)2(1)2, with unit-cell parameters a = b = 75.69, c = 64.18 Å. The structure was determined by the molecular-replacement method and was refined to a final R factor of 22.6% (R(free) = 26.3%). Based on structural homology, the GK0453 protein possesses two independent binding sites and hence it may simultaneously interact with two proteins or with a protein and a nucleic acid.
Piperazion[1,2-A]indol-1-ones and [1,4]Diazepino[1,2-A]indol-1-ones (2014)

ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXTPiperazion[1,2-A]indol-1-ones and [1,4]Diazepino[1,2-A]indol-1-onesBenjamin Blass*View Author Information Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, United States*Tel: 215-707-1085. E-mail: [email protected]Cite this: ACS Med. Chem. Lett. 2014, 5, 6, 621–622Publication Date (Web):April 28, 2014Publication History Received11 April 2014Published online28 April 2014Published inissue 12 June 2014https://pubs.acs.org/doi/10.1021/ml500148yhttps://doi.org/10.1021/ml500148yeditorialACS PublicationsCopyright © 2014 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views773Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (236 KB) Get e-AlertscloseSUBJECTS:Alkyls,Cells,Central nervous system,Diseases and disorders,Group 17 compounds Get e-Alerts
μ-Conotoxins that differentially block sodium channels Na V 1.1 through 1.8 identify those responsible for action potentials in sciatic nerve (2011)

Voltage-gated sodium channels (VGSCs) are important for action potentials. There are seven major isoforms of the pore-forming and gate-bearing α-subunit (Na(V)1) of VGSCs in mammalian neurons, and a given neuron can express more than one isoform. Five of the neuronal isoforms, Na(V)1.1, 1.2, 1.3, 1.6, and 1.7, are exquisitely sensitive to tetrodotoxin (TTX), and a functional differentiation of these presents a serious challenge. Here, we examined a panel of 11 μ-conopeptides for their ability to block rodent Na(V)1.1 through 1.8 expressed in Xenopus oocytes. Although none blocked Na(V)1.8, a TTX-resistant isoform, the resulting "activity matrix" revealed that the panel could readily discriminate between the members of all pair-wise combinations of the tested isoforms. To examine the identities of endogenous VGSCs, a subset of the panel was tested on A- and C-compound action potentials recorded from isolated preparations of rat sciatic nerve. The results show that the major subtypes in the corresponding A- and C-fibers were Na(V)1.6 and 1.7, respectively. Ruled out as major players in both fiber types were Na(V)1.1, 1.2, and 1.3. These results are consistent with immunohistochemical findings of others. To our awareness this is the first report describing a qualitative pharmacological survey of TTX-sensitive Na(V)1 isoforms responsible for propagating action potentials in peripheral nerve. The panel of μ-conopeptides should be useful in identifying the functional contributions of Na(V)1 isoforms in other preparations.
ChemInform Abstract: Reactions of Tetrachloropyridazine with Aliphatic Nitrogen Nucleophiles. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation (2012)

The pentaspan membrane glycoprotein CD133 marks lineage-specific cancer progenitor cells and is associated with poor prognosis in a number of tumor types. Despite its utility as a cancer progenitor cell marker, CD133 protein regulation and molecular function remain poorly understood. We find that the deacetylase HDAC6 physically associates with CD133 to negatively regulate CD133 trafficking down the endosomal-lysosomal pathway for degradation. We further demonstrate that CD133, HDAC6, and the central molecule of the canonical Wnt signaling pathway, β-catenin, can physically associate as a ternary complex. This association stabilizes β-catenin via HDAC6 deacetylase activity, which leads to activation of β-catenin signaling targets. Downregulation of either CD133 or HDAC6 results in increased β-catenin acetylation and degradation, which correlates with decreased proliferation in vitro and tumor xenograft growth in vivo. Given that CD133 marks progenitor cells in a wide range of cancers, targeting CD133 may be a means to treat multiple cancer types.
A high frequency ultrasound aided study of kinetics of drug delivery in tumor models (2012)

The in vivo performance of a Fluorescence Molecular Tomography system as a function of pathophysiological parameters that determine the penetration of nonbinding fluorescent nanoparticle was examined through imaging of a series of three tumor models. The pathophysiological parameters examined were, vessel density, interstitial fluid pressure (IFP), and collagen content. Drug delivery and IFP were measured in vivo via fluorescence spectroscopy and a fiber-optic coupled pressure probe. Vessel density and collagen content were determined ex vivo through histochemical analysis. The kinetics of the 40 nm,10000 KDa, fluorescent particles, which were injected into the tail vein of the mice, was monitored by sequential excitation of the tissue on and off the tumor site through employment of sixteen source detector pairs interspersed linearly in reflectance geometry. Each optical fluorescence data set was collected at discrete time intervals in order to monitor drug uptake for a period of 45 minutes. The kinetics of the drug delivery and the average nanoparticle uptake were correlated with the vessel density, interstitial pressure and collagen content. The results of the correlations were verified to be consistent with the published relationship between the three pathophysiological parameters and nanoparticle drug delivery.
Indications, Techniques, and Complications of Lumbar Interbody Fusion (2002)

Lumbar interbody arthrodesis is a surgical technique that results in fusion of the anterior column of the spine. The indications for this procedure have evolved over time, and current indications include spinal deformity, segmental instability, and discogenic low back pain. Arthrodesis in the interbody space can be accomplished through anterior or posterior approaches to the spine, and these techniques are discussed. Surgical approaches in performing an interbody arthrodesis can be complicated by nerve and vascular injury. Clinical outcome studies are important in better defining the role of lumbar interbody arthrodesis as a substitute for posterior fusion in the lumbar spine.
Picosecond time-resolved UV resonance Raman spectroscopy of the photochemical ring opening of 1,3,5-cyclooctatriene and .alpha.-phellandrene (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPicosecond time-resolved UV resonance Raman spectroscopy of the photochemical ring opening of 1,3,5-cyclooctatriene and .alpha.-phellandrenePhilip J. Reid, Stephen J. Doig, and Richard A. MathiesCite this: J. Phys. Chem. 1990, 94, 22, 8396–8399Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/j100385a006https://doi.org/10.1021/j100385a006research-articleACS PublicationsRequest reuse permissionsArticle Views168Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Critical Problems in Very Large Scale Computer Systems (1988)

Abstract : This is the first semiannual report on this contract. The purpose of the present contract is to investigate limiting technologies for a very large computer system, one which, if built during the mid 1990's, would be so large that the nation could only afford one or two of them. The purpose of this contract is to investigate plausibility, which is defined as the step before feasibility. Once plausibility is demonstrated, then separate efforts at demonstrating feasibility and then design and manufacture would be appropriate. It is estimated that the cost of such 'building-size computer' would be in excess of $1,000,000.000. Six critical areas were identified, and work is in progress in each of these areas. The six areas, and the MIT faculty members who are working in each of the areas, are listed in the chart. The format of this report is based on this table. The work in circuits is a combination of improved techniques in waveform bounding and new ideas in LU factorization and relaxation methods. It has been found that in the context of highly parallel computation, the Gauss-Jacobi technique is never inferior to the Gauss-Seidel technique. Prototype circuits for a proposed processing element have been fabricated, and are under evaluation. The investigation of communications topology and related architectural concerns centers around two projects. In one of them, the Message- Driven Processor is the object of study.
Voltage-tuned resonant reflectance optical filter for visible wavelengths fabricated by nanoreplica molding (2007)

This work describes the first implementation of a plastic-based photonic crystal filter at visible wavelengths that incorporates a variable refractive-index material for voltage-controlled actuation of the transmission wavelength band. Using a replica-molding approach, device structures are inexpensively fabricated over large surface areas, and the fabrication approach enables control of individual regions on the surface of the PC. The talk will describe the device operating principle, rigorous coupled wave analysis and finite difference time domain analysis computer simulation/design methodology, the device fabrication methods, and testing of the reflection/transmission efficiency, tuning range, and response speed.
Ion-mediated conformational switches (2014)

Molecular switches are ubiquitous in Nature and provide the basis of many forms of transport and signalling. <i>Single</i> synthetic molecules that change conformation, and thus function, reversibly in a stimulus-dependent manner are of great interest not only to chemists but society in general; myriad applications exist in storage, display, sensing and medicine. Here we describe recent developments in the area of <i>ion</i>-mediated switching.
Extracellular matrix remodeling following myocardial infarction influences the therapeutic potential of mesenchymal stem cells (2014)

This study demonstrated that decellularization of diseased tissue allows for the exclusive analysis of the remodeled matrix and its ability to influence significantly the cellular phenotype. Characterization of cell fate as a function of myocardial remodeling following infarction is critical in developing the ideal strategy for cell implantation to maximize tissue regeneration and to ultimately reduce the prevalence and severity of heart failure.
Transmission over 2400 km Using an All-ETDM 80-Gbaud (160-Gb/s) QPSK Transmitter and Coherent Receiver (2011)

A single-polarization 160-Gb/s (80-Gbaud) electronically multiplexed (ETDM) single-carrier quadrature phase-shift-keyed (QPSK) signal is transmitted over 2400 km of ultra-large-area fiber. Coherent detection is achieved using two 120-GSamples/s, 45-GHz bandwidth oscilloscope prototypes and off-line digital signal processing.
Intraprotein transmethylation via a CH3–Co(iii) species in myoglobin reconstituted with a cobalt corrinoid complex (2015)

Myoglobin reconstituted with a cobalt tetradehydrocorrin derivative, rMb(Co(TDHC)), was investigated as a hybrid model to replicate the reaction catalyzed by methionine synthase. In the heme pocket, Co(I)(TDHC) is found to react with methyl iodide to form the methylated cobalt complex, CH3-Co(III)(TDHC), although it is known that a similar nucleophilic reaction of a cobalt(i) tetradehydrocorrin complex does not proceed effectively in organic solvents. Furthermore, we observed a residue- and regio-selective transmethylation from the CH3-Co(III)(TDHC) species to the Nε2 atom of the His64 imidazole ring in myoglobin at 25 °C over a period of 48 h. These findings indicate that the protein matrix promotes the model reaction of methionine synthase via the methylated cobalt complex. A theoretical calculation provides support for a plausible reaction mechanism wherein the axial histidine ligation stabilizes the methylated cobalt complex and subsequent histidine-flipping induces the transmethylation via heterolytic cleavage of the Co-CH3 bond in the hybrid model.
Default-Mode Network Disruption in Mild Traumatic Brain Injury (2012)

These results showed abnormal DMN connectivity patterns in patients with MTBI, which may provide insight into how neuronal communication and information integration are disrupted among DMN key structures after mild head injury.