gebhart/patrepeval huggingface dataset:
Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy (2017)

5'-Adenosine monophosphate-activated protein kinase (AMPK) is a master regulator of energy homeostasis in eukaryotes. Despite three decades of investigation, the biological roles of AMPK and its potential as a drug target remain incompletely understood, largely because of a lack of optimized pharmacological tools. We developed MK-8722, a potent, direct, allosteric activator of all 12 mammalian AMPK complexes. In rodents and rhesus monkeys, MK-8722-mediated AMPK activation in skeletal muscle induced robust, durable, insulin-independent glucose uptake and glycogen synthesis, with resultant improvements in glycemia and no evidence of hypoglycemia. These effects translated across species, including diabetic rhesus monkeys, but manifested with concomitant cardiac hypertrophy and increased cardiac glycogen without apparent functional sequelae.
Novel immunoFET based on impedance spectroscopy for cortisol detection: application for heart failure (2019)

International audience
Ultra-thin near infrared camera enabled by a flat multi-level diffractive lens: erratum (2020)

In Opt. Lett. 44 , 5450 ( 2019 ) OPLEDP 0146-9592 10.1364/OL.44.005450 , there were errors in the author listing and in one figure.
A Systematic Approach to Reduce the System Bus Load and Power in Multimedia Algorithms (2000)

Multimedia algorithms deal with enormous amounts of data transfers and storage, resulting in huge bandwidth requirements at the off‐chip memory and system bus level. As a result the related energy consumption becomes critical. Even for execution time the bottleneck can shift from the CPU to the external bus load. This paper demonstrates a systematic software approach to reduce this system bus load. It consists of source‐to‐source code transformations, that have to be applied before the conventional ILP compilation. To illustrate this we use a cavity detection algorithm for medical imaging, that is mapped on an Intel Pentium® II processor.
Supplementary Table 3 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq (2023)

Supplementary Table 3 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Computing using quantum dynamics of nanostructured arrays (2019)

Quantum field is back at the headlines with several research areas such as: quantum sensing, quantum communication, quantum cryptography and quantum computing. A novel concept of a computer exploiting quantum confinement and nonlinear optics is the basis of an EC H2020 consortium named COPAC [1,2,3]. We joined this consortium which uses the dynamic response of assembled nanostructures in solid arrays short laser pulses and implement a novel paradigm for parallel information processing. Within current paper we will discuss the nanostructures materials and configurations as designed for the project, especially the interaction of the nanostructures with the addressing laser beam unit.
EFFECT OF ANTENNA ARRAY GEOMETRY AND ULA AZIMUTHAL ORIENTATION ON MIMO CHANNEL PROPERTIES IN URBAN CITY STREET GRID (2006)

Propagation environment and antenna array configuration have significant effect on spatial correlation properties of multipleinput multiple-output (MIMO) wireless communications channels. In this paper the effect of different antenna array geometries on MIMO channel properties is investigated in urban city street grid propagation environment. Four antenna array geometries with the same number of antenna elements and fixed inter-element spacing are considered, namely, uniform linear array (ULA), uniform circular array (UCA), uniform rectangular array (URA) and uniform cubic array (UCuA). The effect of ULA orientation in azimuthal plane on MIMO channel ergodic capacity is also investigated. Varying orientation angle from 0 to at the two communication ends is considered. The investigation is carried out based on three dimensional (3D) spatial multi-ray realistic propagation channel model covering different propagation types. It is shown that the antenna array geometry have significant impact on MIMO channel properties. Under different propagation scenarios the ULA shows superiority to the other considered geometries in terms of the ergodic channel capacity and number of spatial parallel channels. However, this superiority depends largely on the array azimuthal orientation.
Digging Deeper Into the Pyriproxyfen-Response of the Amphipod Gammarus fossarum With a Next-Generation Ultra-High-Field Orbitrap Analyser: New Perspectives for Environmental Toxicoproteomics (2018)

Taxon-specific proteins from sentinel species have been shown to be among the most relevant proteins to monitor the biological effects of anthropogenic contaminations. Shotgun proteomics allows high-throughput analysis of animal proteomes, but comprehensive coverage remains difficult to achieve due to the wide dynamic range. Here, the advantages of a new generation of mass analyser for environmental toxicoproteomics are documented through the identification of candidate biomarkers in a sentinel animal species for which the genome is as yet unsequenced. A label-free comparative proteomic study was performed on testis from the freshwater amphipod Gammarus fossarum challenged with 0.5 µg or 50 µg/L pyriproxyfen, a juvenile hormone analogue used as an insecticide. A total of 4,031 proteins could be monitored with a Q Exactive HF mass spectrometer incorporating an ultra-high-field Orbitrap analyser. Five times more MS/MS spectra and 4-fold more peptides and proteins were identified with this instrument compared to a LTQ Orbitrap XL spectrometer. Comparison of protein abundance between control and organisms exposed to 0.5 µg or 50 µg/L pyriproxyfen indicated that 32 and 21 proteins, respectively, were significantly modulated between test and control conditions. Functional annotation of these novel candidate biomarkers and their specificities are discussed in light of their potential applications in freshwater quality monitoring. The potential contribution of next-generation mass spectrometers to environmental toxicoproteomics is also touched on.
Novel intra prediction modes for VP10 codec (2016)

The demand for high quality video is permanently on the rise and with it the need for more effective compression. Compression scope can be further expanded due to increased spatial correlation of pixels within a high quality video frame. One basic feature that takes advantage of pixels’ spatial correlation for video compression is Intra-Prediction, which determines the codec’s compression efficiency. Intra-Prediction enables significant reduction of the Intra-frame (I-frame) size and, therefore, contributes to more efficient bandwidth exploitation. It has been observed that the intra frame coding efficiency of VP9 is not as good as that of H.265/MPEG-HEVC. One possible reason is that HEVC’s Intra-prediction algorithm uses as many as 35 prediction directions, while VP9 uses only 9 directions including the TM prediction mode. Therefore, there is high motivation to improve the Intra-Prediction scheme with new, original and proprietary algorithms that will enhance the overall performance of Google’s future codec and bring its performance closer to that of HEVC. In this work, instead of using different angles for predictions, we introduce four unconventional Intra-Prediction modes for the VP10 codec – Weighted CALIC (WCALIC), Intra-Prediction using System of Linear Equations (ISLE), Prediction of Discrete Cosine Transformations (PrDCT) Coefficients and Reverse Least Power of Three (RLPT). Employed on a selection eleven (11) typical images with a variety of spatial characteristics, by using Mean Square Error (MSE) evaluation criteria, we show that our proposed algorithms (modes) were preferred and thus selected around 57% of the blocks, resulting in a reduced average prediction error, i.e. the MSE of 26%. We believe that our proposed techniques will achieve higher compression without compromising video quality, thus improving the Rate-Distortion (RD) performances of the compressed video stream.
Target-in-the-Loop Adaptive Optics: Wavefront Control in Strong Speckle-Modulation Conditions (2002)

A 37-control-channel adaptive optics target-in-the loop system with phase correction of the outgoing wave capable of operating in the presence of speckle-field-induced strong intensity modulation is presented. System operation is based on speckle field metric optimization using the stochastic parallel gradient descent technique. A quadratic map that linearizes phase modulation response of deformable micromachined mirror to control variable perturbation is investigated. Results demonstrate that adaptive wavefront correction using speckle-field-based beam quality metrics can significantly improve laser beam concentration on extended objects. The use of the quadratic map improves both system convergence rate and magnitude of laser beam concentration on the target.
Issues Associated With Polarization Independence in Silicon Photonics (2006)

Interest in silicon photonics is experiencing a dramatic increase due to emerging applications areas and several high profile successes in device and technology development. Despite early work dating back to the mid-1980s, dramatic progress has been made only in the recent years. While many approaches to research have been developed, the striking difference between the work of the early to mid-1990s, and more recent work, is that the latter has been associated with a trend to reduce the cross sectional dimensions of the waveguides that form the devices. The question arises therefore, as to whether one should move to very small strip waveguides (silicon wires) of the order of 250 nm in height and a few hundred nanometres in width for improved device performance but with little hope of polarization independence, or to utilize slightly larger rib waveguides that offer more opportunity to control the polarization dependence of the devices. In this paper, we discuss the devices suitable for one approach or the other, and present the designs associated both with strip and rib waveguides. In particular, we present the designs of polarization-independent ring resonators with free spectral ranges up to 12 nm, we propose modulators for bandwidths in the tens of gigahertz regime, and present grating-based couplers for rib and strip waveguides, and/or for wafer scale testing, as well as a novel means of developing Bragg gratings via ion implantation
ILAC: An Automated Layout Tool for Analog CMOS Circuits (2009)

ILAC (Interactive Layout of Analog CMOS Circuits) is a process-independent tool that automatically generates geometrical layout for analog CMOS cells from a circuit description. ILAC handles typical analog layout constraints such as device matching, symmetry, and distance and coupling constraints. ILAC supports user-specified constraints on cell height and input/output pin locations. Together with the design tool IDAC (Interactive Design for Analog CMOS Circuits), ILAC makes a fully functional analog CMOS cell compiler that automatically produces geometrical layout from functional specifications for a library of circuits including amplifiers, voltage and current references, comparators, oscillators, and A/D converters.
Thermodynamic Analysis of Autonomous Parallel β-Sheet Formation in Water (2006)

We report the first thermodynamic analysis of parallel beta-sheet formation in a model system that folds in aqueous solution. NMR chemical shifts were used to determine beta-sheet population, and van't Hoff anaysis provided thermodynamic parameters. Our approach relies upon the d-prolyl-1,1-dimethyl-1,2-diaminoethane unit to promote parallel beta-sheet formation between attached peptide strands. The development of a macrocyclic reference molecule to provide chemical shift data for the fully folded state was crucial to the quantitative anaylsis.
ANIARA Project - Automation of Network Edge Infrastructure and Applications with Artificial Intelligence (2023)

Emerging use-cases like smart manufacturing and smart cities pose challenges in terms of latency, which cannot be satisfied by traditional centralized infrastructure. Edge networks, which bring computational capacity closer to the users/clients, are a promising solution for supporting these critical low latency services. Different from traditional centralized networks, the edge is distributed by nature and is usually equipped with limited compute capacity. This creates a complex network to handle, subject to failures of different natures, that requires novel solutions to work in practice. To reduce complexity, edge application technology enablers, advanced infrastructure and application orchestration techniques need to be in place where AI and ML are key players.
High performance field emission properties of graphite nanoplatelet field emitters (2013)

Graphite nanoplatelet (GNP) that consists of several tens of layers of graphene sheets is a promising candidate for electron field emission. The GNP emitter shows good field emission properties with a high emission current and a robust long-term stability because of the sharp edges, the high aspect ratio, and the stacked graphene sheets. Most of the electrons are emitted from the sharp edges of GNPs. The GNP emitters fabricated by the screen printing method reveal the turn-on electric field of 1.77 V/μm, the threshold electric field of 4.47 V/μm, the maximum emission current density of 39 mA/cm2, and the good emission stability for 20 h with little degradation rate of the emission current. The GNP field emitters can be a good candidate for several field emission applications such as flat lamps, field emission displays, and x-ray sources.
Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition (2005)

Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and therefore has a pivotal role in regulating the formation of biologically active steroids. The enzyme is widely distributed throughout the body, and its action is implicated in physiological processes and pathological conditions. The crystal structure of the enzyme has been resolved, but relatively little is known about what regulates its expression or activity. Research into the control and inhibition of this enzyme has been stimulated by its important role in supporting the growth of hormone-dependent tumors of the breast and prostate. STS is responsible for the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone, respectively, both of which can be converted to steroids with estrogenic properties (i.e., estradiol and androstenediol) that can stimulate tumor growth. STS expression is increased in breast tumors and has prognostic significance. The role of STS in supporting tumor growth prompted the development of potent STS inhibitors. Several steroidal and nonsteroidal STS inhibitors are now available, with the irreversible type of inhibitor having a phenol sulfamate ester as its active pharmacophore. One such inhibitor, 667 COUMATE, has now entered a phase I trial in postmenopausal women with breast cancer. The skin is also an important site of STS activity, and deficiency of this enzyme is associated with X-linked ichthyosis. STS may also be involved in regulating part of the immune response and some aspects of cognitive function. The development of potent STS inhibitors will allow investigation of the role of this enzyme in physiological and pathological processes.
IL-18 Has IL-12-Independent Effects in Delayed-Type Hypersensitivity: Studies in Cell-Mediated Crescentic Glomerulonephritis (2000)

Abstract IL-18 (formerly known as IFN-γ-inducing factor) enhances Th1 responses via effects that are thought to be dependent on and synergistic with IL-12. The potential for IL-18 to exert IL-12-independent effects in delayed-type hypersensitivity (DTH) responses was studied in a model of Th1-directed, DTH-mediated crescentic glomerulonephritis induced by planting an Ag in glomeruli of sensitized mice as well as in cutaneous DTH. Sensitized genetically normal (IL-12+/+) mice developed proteinuria and crescentic glomerulonephritis with a glomerular influx of DTH effectors (CD4+ T cells, macrophages, and fibrin deposition) in response to the planted glomerular Ag. IL-12p40-deficient (IL-12−/−) mice showed significant reductions in crescent formation, proteinuria, and glomerular DTH effectors. Administration of IL-18 to IL-12−/− mice restored the development of histological (including effectors of DTH) and functional glomerular injury in IL-12−/− mice to levels equivalent to those in IL-12+/+ mice. IL-18 administration to IL-12−/− mice increased glomerular ICAM-1 protein expression, but did not restore Ag-stimulated splenocyte IFN-γ, GM-CSF, IL-2, or TNF-α production. Sensitized IL-12+/+ mice also developed cutaneous DTH following intradermal challenge with the nephritogenic Ag. Cutaneous DTH was inhibited in IL-12−/− mice, but was restored by administration of IL-18. IL-12+/+ mice given IL-18 developed augmented injury, with enhanced glomerular and cutaneous DTH, demonstrating the synergistic effects of IL-18 and IL-12 in DTH responses. These studies demonstrate that even in the absence of IL-12, IL-18 can induce in vivo DTH responses and up-regulate ICAM-1 without inducing IFN-γ, GM-CSF, or TNF-α production.
Ultra-narrowband optical fiber Bragg grating filters for water vapor lidar atmospheric measurements (2004)

An ultra narrowband, high transmission fiber Bragg grating optical filter at 946 nm is presented for water vapor lidar measurements. The filter and water line have the same bandwidths, significantly reducing optical background in lidar receivers.
Injectable hyaluronic acid hydrogels encapsulating drug nanocrystals for long‐term treatment of inflammatory arthritis (2021)

Antiproliferative chemotherapeutic agents offer a potential effective treatment for inflammatory arthritis. However, their clinical application is limited by high systemic toxicity, low joint bioavailability as well as formulation challenges. Here, we report an intra-articular drug delivery system combining hyaluronic acid hydrogels and drug nanocrystals to achieve localized and sustained delivery of an antiproliferative chemotherapeutic agent camptothecin for long-term treatment of inflammatory arthritis. We synthesized a biocompatible, in situ-forming injectable hyaluronic acid hydrogel using a naturally occurring click chemistry: cyanobenzothiazole/cysteine reaction, which is the last step reaction in synthesizing <i>D</i>-luciferin in fireflies. This hydrogel was used to encapsulate camptothecin nanocrystals (size of 160-560 nm) which released free camptothecin in a sustained manner for 4 weeks. In vivo studies confirmed that the hydrogel remained in the joint over 4 weeks. By using the collagen-induced arthritis rat model, we demonstrate that the hydrogel-camptothecin formulation could alleviate arthritis severity as indicated by the joint size and interleukin-1β level in the harvested joints, as well as from histological and microcomputed tomography evaluation of joints. The hydrogel-nanocrystal formulation strategy described here offers a potential solution for intra-articular therapy for inflammatory arthritis.
Methyltrioxorhenium as Catalyst for Olefin Oxidation (1991)

The pronounced Lewis acidity explains the exceptional activity of the title compound as catalyst for olefin epoxidations with hydrogen peroxide. The system MTO/ t BuOH/H 2 O 2 transforms olefins selectively and efficiently into epoxides under very mild conditions (−30 to + 60°C, but normally at room temperature). In general, 0.1 to 1 mol% MTO is sufficient to achieve high turnovers. Variation of the alkyl group and addition of cocatalysts (e.g. amines) should influence activity and stereoselectivity.
Effect of Rebamipide on Acetic Acid-induced Gastric Ulcer in Rats: Involvement of Hepatocyte Growth Factor (2003)

The study suggests that rebamipide has anti-ulcerative effects on gastric mucosal cells via up-regulation of HGF, c-met, Cox-2 and EP2.
A Machine Learning Approach for the Classification of Indoor Environments Using RF Signatures (2018)

Efficient deployment of Internet of Things (IoT) sensors primarily depends on allowing the adjustment of sensor power consumption according to the radio frequency (RF) propagation channel which is dictated by the type of the surrounding indoor environment. This paper develops a machine learning approach for indoor environment classification by exploiting support vector machine (SVM) based on RF signatures computed from real-time measurements. Results obtained demonstrate that the combination of received signal strength (RSS) and channel transfer function (CTF) yields a classification accuracy of 83.0% for identifying the type of the indoor environment.
Inorganic Nanovehicle Targets Tumor in an Orthotopic Breast Cancer Model (2014)

The clinical efficacy of conventional chemotherapeutic agent, methotrexate (MTX), can be limited by its very short plasma half-life, the drug resistance, and the high dosage required for cancer cell suppression. In this study, a new drug delivery system is proposed to overcome such limitations. To realize such a system, MTX was intercalated into layered double hydroxides (LDHs), inorganic drug delivery vehicle, through a co-precipitation route to produce a MTX-LDH nanohybrid with an average particle size of approximately 130 nm. Biodistribution studies in mice bearing orthotopic human breast tumors revealed that the tumor-to-liver ratio of MTX in the MTX-LDH-treated-group was 6-fold higher than that of MTX-treated-one after drug treatment for 2 hr. Moreover, MTX-LDH exhibited superior targeting effect resulting in high antitumor efficacy inducing a 74.3% reduction in tumor volume compared to MTX alone, and as a consequence, significant survival benefits. Annexin-V and propidium iodine dual staining and TUNEL analysis showed that MTX-LDH induced a greater degree of apoptosis than free MTX. Taken together, our data demonstrate that a new MTX-LDH nanohybrid exhibits a superior efficacy profile and improved distribution compared to MTX alone and has the potential to enhance therapeutic efficacy via inhibition of tumor proliferation and induction of apoptosis.
Relaxation Behaviors of Monolayers of Octadecylamine and Stearic Acid at the Air/Water Interface (2004)

This study investigated the relaxation behaviors of octadecylamine (ODA), stearic acid (SA), and SA/ODA mixed monolayers at the air/water interface. Area relaxations of monolayers at constant surface pressure were studied by a nucleation and growth mechanism and by direct observation using a Brewster angle microscope (BAM). The results showed that ODA and SA monolayers exhibit different characteristics in the area loss and in the BAM morphology. In the initial relaxation stage, SA monolayer illustrates a more stable characteristic than ODA. But at the later stage, the area loss of SA monolayer increases more quickly than that for ODA due to significant nucleation and growth of 3D aggregates. The BAM results demonstrated that 3D aggregates of large scale domains are likely to form on a SA monolayer even when the area loss is insignificant. On the contrary, only dotlike aggregates of low density were found on the ODA monolayer when relaxation is carried out at higher surface pressure. The relaxation behavior of SA monolayer can be described by the Vollhardt model. However, the relaxation of ODA monolayer does not follow the nucleation model described by Vollhard but can reasonably be attributed to the effect of dissolution. For the SA/ODA mixed monolayers, the relaxation behaviors in the initial and final stages follow different mechanisms, which is attributed to the formation of distinct phases as observed from the BAM. This result also implied that SA and ODA are not completely miscible to be a homogeneous phase. Phases of various compositions were formed in the mixed monolayers, and thus, the relaxation mechanism was shifted during the relaxation process as dominated by different relaxation behaviors of various phases.