gebhart/patrepeval huggingface dataset:
The Influence of Mycophenolate Mofetil and Azathioprine on the Same Cadaveric Donor Renal Transplantation (2005)

In order to evaluate whether immunosuppressive agents such as mycophenolate mofetil (MMF) and azathioprine would differently influence the outcome of the renal transplants, we prospectively analyzed the incidence of acute rejection episodes, cytomegalovirus infection within the first 6 months following renal transplantation and 5 yr graft survival rate after minimizing influences of donor factors by grafting the same cadaveric donor kidney. There was no significant difference in sex, HLA mismatch, cold ischemic time, and patients' weight between the two groups. Contrary to the previous studies which demonstrated that MMF could lower the incidence of acute rejection episodes and improved graft survival rate, the two groups showed no significant difference in the incidence of acute rejection episodes and 5-yr graft survival rate as well. This discrepancy in these results might explain that donor factors could be important to cadaveric renal transplantation. Thus, we suggest that the influences of donor factors should be considered in further clinical studies of cadaveric renal transplantation.
NEW TECHNIQUES IN ION CYCLOTRON RESONANCE SPECTROMETRY (1982)

Three new experimental techniques involving ion cyclotron resonance spectrometry are described in this thesis. The first of these, electron impact excitation of ions from organics (EIEIO) involves trapping ions in the space charge potential of an electron beam, where they are excited by electron impact and subsequently undergo dissociation. Spectra obtained by this method for a variety of substituted benzene radical cations are shown to be analogous to those obtained by collision-induced dissociation and yield characteristic structural information. The second technique involves the use of a pulsed laser ionization source in conjunction with ion cyclotron resonance detection. The use of this source to generate and study the gas-phase ion-molecule reaction chemistry of atomic metal ions is considered, along with a discussion of how such metal ions may be useful as new chemical ionization reagents. The third technique involves the use of Fourier transform mass spectrometry to obtain collision-induced dissociation spectra. The fundamental features of this technique are discussed, along with its application to high resolution detection of CID fragments, observation of consecutive CID reactions, and obtaining breakdown curves.
Three-dimensional organization of promyelocytic leukemia nuclear bodies (2010)

Promyelocytic leukemia nuclear bodies (PML-NBs) are mobile subnuclear organelles formed by PML and Sp100 protein. They have been reported to have a role in transcription, DNA replication and repair, telomere lengthening, cell cycle control and tumor suppression. We have conducted high-resolution 4Pi fluorescence laser-scanning microscopy studies complemented with correlative electron microscopy and investigations of the accessibility of the PML-NB subcompartment. During interphase PML-NBs adopt a spherical organization characterized by the assembly of PML and Sp100 proteins into patches within a 50- to 100-nm-thick shell. This spherical shell of PML and Sp100 imposes little constraint to the exchange of components between the PML-NB interior and the nucleoplasm. Post-translational SUMO modifications, telomere repeats and heterochromatin protein 1 were found to localize in characteristic patterns with respect to PML and Sp100. From our findings, we derived a model that explains how the three-dimensional organization of PML-NBs serves to concentrate different biological activities while allowing for an efficient exchange of components.
High-quality photonic sampling streams from a semiconductor diode ring laser (2002)

We report on the development of an ultralow-noise, external-cavity, actively mode-locked semiconductor diode laser for application in next-generation photonic sampling systems. A summary of harmonically mode-locked noise characteristics in a 65-MHz ring cavity is presented through the range of pulse repetition frequencies between 130 MHz and 8.3 GHz (2nd-128th harmonic). Important implications regarding the use of gain-versus-loss modulation as the active modelocking mechanisms are discussed. We also report what are, to our knowledge, the lowest noise characteristics achieved to date for a semiconductor diode laser operating at 10 GHz. Individually optimized results of 0.12% rms amplitude noise (10 Hz-10 MHz), and 43 fs rms residual phase jitter (10 Hz-10 MHz) provide a theoretical resolution of 8.6 bits in a 10-GSPS optical analog-to-digital converter. We have also achieved dispersion-compensated pulsewidths; as short as 1.2 ps, and shown successful operation of a novel phase-locked-loop capable of reducing the rms; residual phase noise by as much as 91% within its response bandwidth. Finally, the first measurements of residual phase noise out to the Nyquist frequency (5 GHz) are presented, providing an upper bound on the rms residual phase jitter of 121 fs (10 Hz-5 GHz).
State of the art and recent development of embedded network solutions research (2008)

Recently we could observe a huge change in the mobile industry when the original idea of mobile phone was transformed into the new concept of mobile multimedia devices capable to perform multiple complex tasks and integrating a number of functionalities. As a consequence it resulted in significant increase of the device integration time and cost and complicated deployment of the new technologies. The device integrators are forced to favor modularity everywhere where it is possible in design of new devices, which results in a new trend towards networked architectures for the mobile devices. However, moving towards networked architectures specifically designed to overcome limitations brought by the mobile devices is a time consuming task. It requires fresh mind analysis of many solutions applied in other contexts, since some of the constraints and requirements are unique in comparison with e.g. SoC, NoC, which are the most known embedded network solutions, and of course they are significantly different comparing to the wide area networks. The main differentiating factors are: strongly constrained power consumption by the battery life time; and a need for modular architecture to allow reuse of the existing components or modules. The paper provides an overview of the state of art in the embedded networks research and describes general background for our studies, key assumptions, restrictions and limitations that we faced at the beginning of development of the embedded networks architecture for mobile devices.
Relationships between neuroendocrine differentiation and sensitivity to gamma-radiation in culture line OH-1 of human small cell lung carcinoma. (1982)

After 16 months, an established line of human small cell lung cancer (OH-1) underwent a subtle morphological change which was associated with a virtually complete loss of neuroendocrine differentiation as judged by electron microscopy studies and a 12-fold loss in L-dopa decarboxylase activity. In nude (athymic) mouse heterotransplants, the histology of the early-passage cells (oat or lymphocyte-like) differed only slightly from the late-passage cells (intermediate or polygonal type); cytology studies showed no diagnostic differences between the passages. However, the early-passage endocrine-like cells showed up to 100-fold less cell survival after irradiation than the late-passage cells. Thus, subtle changes in the morphology of OH-1 cells are accompanied by a profound loss of neuroendocrine differentiation and the emergence of radiation resistance. These changes could have important parallelisms for behavior of small-cell lung carcinoma in humans. The cell culture model described may be useful in investigating the interrelationships occurring between endocrine and nonendocrine cells in the spectrum of human lung cancer. The findings emphasize that neuroendocrine-related ultrastructure and biochemistry may help define important cell populations in lung cancer with respect to therapeutic sensitivity.
OEFinder: a user interface to identify and visualize ordering effects in single-cell RNA-seq data (2016)

Supplementary data are available at Bioinformatics online.
Specification and management of QoS in imprecise real-time databases (2003)

Real-time applications such as e-commerce, flight control, chemical and nuclear control, and telecommunication are becoming increasingly sophisticated in their data needs, resulting in greater demands for real-time data services. Since the workload of real-time databases (RTDBs), providing real-time data services, cannot be precisely predicted, they can become overloaded and thereby cause temporal violations, resulting in a damage or even a catastrophe. Imprecise computation techniques address this problem and allow graceful degradation during overloads. In this paper, we present a framework consisting of a model for expressing QoS requirements in terms of data and transaction preciseness, an architecture based on feedback control scheduling, and a set of algorithms implementing different policies and behaviors. Our approach gives a robust and controlled behavior of RTDBs, even for transient overloads and with inaccurate run-time estimates of the transactions. Further, performance experiments show that the proposed algorithms outperform a set of baseline algorithms, including FCS-EDF that schedules the transactions using EDF and feedback control.
Ni-Sn solid liquid interdiffusion (SLID) bonding — Process, bond characteristics and strength (2016)

Ni-Sn joints created by solid liquid interdiffusion (SLID) bonding were investigated. Process parameters were varied between 300 °C and 360 °C with annealing times up to 20 min to study the joint development. Symmetric Ni / Ni-Sn intermetallic compound / Ni joints were fabricated. It was found that a bond profile of 5 min at 300 °C was insufficient to completely solidify the joint. 5 min at 360 °C or 20 min at 300 °C solidified the joint and initiated the homogenization stage to form a stable high temperature compatible Ni / Ni <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn / Ni joint structure. Early development of scallop shaped structures of Ni <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> between the Ni and Sn layers was observed. Coalescent scallops form solid pillars between die and substrate, which results in large irregular voids in the center of the bond line. Initial shear strength results indicate extremely strong bonds, with a joint strength of more than 200 MPa.
Mirror Pulse Modulation for Image Sensor-based Optical Wireless Communication (2021)

This paper describes Mirror Pulse Modulation (MPM), which is an image sensor-based optical wireless communication protocol using line scan sampling. MPM is designed to be featured on current and future smartphones, and has the advantages of a wide communication range and the ability to transmit small pieces of information at high speed. MPM has been published as IEEE standard 802.15.7-2018, but this is the first paper to describe it in detail. We evaluate here the performance of MPM with parameter settings individually optimized for several scenarios. Our results show a 4.4-fold increase in communication range and a 2.3 fold increase in dimming rate compared to International Electrotechnical Commission (IEC) standard 62943:2017, which is adopted in several commercial services.
Dynamic Resource Assignment and Cooperative Relaying in Cellular Networks: Concept and Performance Assessment (2009)

Relays are a cost-efficient way to extend or distribute high data rate coverage more evenly in next generation cellular networks. This paper introduces a radio resource management solution based on dynamic and flexible resource assignment and cooperative relaying as key technologies to enhance the downlink performance of relay-based OFDMA cellular networks. It is illustrated how the dynamic resource assignment is combined with beamforming in a macrocellular deployment and with soft-frequency reuse in a metropolitan area deployment. The cooperative relaying solution allows multiple radio access points to cooperatively serve mobile stations by combining their antennas and using the multiantenna techniques available in the system. The proposed schemes are compared to BS only deployments in test scenarios, which have been defined in the WINNER project to be representative for next generation networks. The test scenarios are well defined and motivated and can serve as reference scenarios in standardisation and research. The results show that the proposed schemes increase the average cell throughput and more importantly the number of users with low throughput is greatly reduced.
Endothelial Junctional Protein Internalization in Inflammation (2006)

Junctional proteins (cadherins and occludin) are important components of endothelial adherens and tight junctions that are remodeled during inflammation, potentially through transient internalization. Junctional protein displacement from the cell surface could represent an important mechanism to decrease homotypic bonding, allowing transient increases in solute flux. Later recycling of these elements to the cell surface would restore junction competence and barrier. Ca++‐switch and exposure to inflammatory mediators promote the internalization of endothelial pan‐reactive and VE‐cadherins but not occludin which redistributes, but is apparently not remodeled acutely. These internalization events are actin‐cytoskeleton and PKC‐dependent and can be correlated with simultaneous reciprocal changes in cell‐substrate adhesion which may maintain structural integrity during periods of altered microvascular barrier.
Thermal and morphological comparisons of blends of metallocene and ziegler-NATTA ultra low density polyethylene (ULDPE) with polypropylene (PP) (1996)

Polypropylene without any modification is too brittle for any use at sub-ambient temperatures. Blends of polypropylene with various ULDPE resins were made to investigate how much the material toughness could be improved and what affect the modifier had on the structure of the composite. DSC analysis of these materials indicates that the crystallinity of these modifiers has been significantly retarded. It is proposed that there is an amorphous shell around the modifier particle because it exhibited a lower beat of fusion than expected.
Fully interconnected, two-dimensional neural arrays using wavelength-multiplexed volume holograms (1991)

We present a compact method to provide independent weighted interconnections between every pixel in a two-dimensional input array and every pixel in a two-dimensional output array. The two input dimensions and two output dimensions are connected by a four-dimensional weight matrix consisting of wavelength-multiplexed volume holograms that use cryogenic spectral hole burning in a single holographic element.
Improved assessment of pulsatile blood flow during resuscitation using Doppler ultrasound (2006)

Early defibrillation is critical for successful resuscitation of a sudden cardiac arrest patient. Defibrillators currently do not assess the patient&apos;s heartbeat or blood circulation and the responder has to manually check for the pulse, a procedure known to be very inaccurate. Previously we had developed an ultrasound Doppler based approach to determine the presence of blood flow in the context of resuscitation. Here we extend our earlier work to develop a generalized pulsation index based on a spectral analysis of the Doppler signal. This new method has the advantage to better distinguish between states of pulse and pulselessness, since it aims at capturing the essentially non-sinusoidal behaviour of cardiac activity. In turn, this leads to better sensitivity and specificity for pulsatile flow assessment. The method was demonstrated on data from pigs undergoing cardiac arrest and defibrillation. (4 pages)
Synaptic Remodeling of the Auditory Cortex Following Bilateral Blindness: Evidence of Cross-modal Plasticity (2022)

We aimed to evaluate structural dynamic changes of neurons in the auditory cortex after visual deprivation. We longitudinally tracked dendritic spines for 3 weeks after visual deprivation in vivo using a two-photon microscope. GFP-labeled dendritic spines in the auditory cortex were serially followed after bilateral enucleation. The turnover rate, density, and size of the spines in the dendrites were evaluated 1, 2, and 3 weeks after visual deprivation. The turnover rate of the dendritic spines in the auditory cortex increased at 1 week (20.17.3%) after bilateral enucleation compared to baseline (12.57.9%); the increase persisted for up to 3 weeks (20.911.0%). The spine loss rate was slightly higher than the spine gain rate. The average spine density (number of spines per 1 m of dendrite) was significantly lower at 2 weeks (2W; 0.220.06 1/m) and 3 W (0.220.08 1/m) post-nucleation compared to baseline (0.0260.09 1/m). We evaluated the change of synaptic strength in the stable spines at each time point. The normalized spine size in the auditory cortex was significantly increased after bilateral blindness at 1 W postoperatively (1.360.92), 2 W postoperatively (1.401.18), and 3 W postoperatively (1.360.88) compared to baseline. Sensory deprivation resulted in remodeling of the neural circuitry in the spared cortex, via cross-modal plasticity in the direction of partial breakdown of synapses, and enhanced strength of the remaining synapses.
A 53% high efficiency GaAs vertically integrated multi-junction laser power converter (2008)

Summary form only given. Power-by-light schemes to provide electrical power to remote opto-electronic modules typically involve the use of multi-segmented photovoltaic (PV) cells or commonly known as laser power converters (LPC) illuminated by an optical fiber to produce output voltages between 2 and 12 volts, with up to several hundred milliwatts of electrical power. Typically these photovoltaic devices are based on a GaAs single junction cell grown on semi-insulating GaAs substrates and they are further segmented and connected in series depending on the output voltage required. Theoretically, these cells should have efficiencies near 60% but currently these cells have efficiencies only in the range of 40 to 45%. Optical losses due to high grid metal coverage and cell isolation trench can reduce efficiency by nearly 10%. In order to eliminate the losses in the multi-segmented cells and to improve the efficiencies further we have designed a vertical multi junction device. The vertical multi-junction approach has several advantages over the multi- segmented approach. The advantages are; a) reduction in optical losses due to trench formation, b) lower metal obscuration losses, due to lower current density in the device, c) reduction of sheet conduction losses, and d) simple process to fabricate the devices. We have successfully designed and fabricated a new vertical multi-junction TV laser power converter with an efficiency of over 53%, a considerably higher efficiency than the regular multi-segmented 2V GaAs laser power converter and this is the highest efficiency reported so far for a photovoltaic device.
Improvement of photoelectrochemical hydrogen generation by surface modification of p-type silicon semiconductor photocathodes (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImprovement of photoelectrochemical hydrogen generation by surface modification of p-type silicon semiconductor photocathodesRaymond N. Dominey, Nathan S. Lewis, James A. Bruce, Dana C. Bookbinder, and Mark S. WrightonCite this: J. Am. Chem. Soc. 1982, 104, 2, 467–482Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/ja00366a016https://doi.org/10.1021/ja00366a016research-articleACS PublicationsRequest reuse permissionsArticle Views2505Altmetric-Citations295LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Novel Algorithm of Wavefront-Matching Method for Stable and Efficient Design of Si Waveguides (2022)

We propose a novel algorithm of a wavefront-matching (WFM) method for the design of silicon waveguides. A conventional WFM method may not provide a stable design of silicon waveguides because of its high-index contrast. In the proposed method, a proper constraint is imposed on a conventional method depending on the device performance. Effectiveness of the proposed method is demonstrated through the design of TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> -TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> mode converter (MC) in detail. The conversion efficiency of the TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> -TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> MC is −0.52 dB at the wavelength of 1550 nm. As another example, TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> -TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> MC was designed by the proposed method to additionally demonstrate its effectiveness.
SPM-Tolerant Pulse Shaping for 40- and 100-Gb/s Dual-Polarization QPSK Systems (2010)

An intersymbol-interference-free pulse shape is specifically designed for self-phase-modulation (SPM) mitigation. It is experimentally shown to increase the SPM tolerance of a 40-Gb/s single-channel postcompensated dual-polarization quadrature phase-shift keying system by 1.5 dB. Numerical analyses at 40 and 100 Gb/s indicate that the specialized pulse shape can increase the maximum reach for G.652 fiber and G.655 fiber up to 1190 and 820 km, respectively.
Ibritumomab Tiuxetan Radioimmunotherapy Is Safe and Well Tolerated in Patients With Relapsed or Refractory B-Cell Non-Hodgkin’s Lymphoma (2001)

Ibritumomab tiuxetan (Zevalin) consists of an anti-CD20 murine IgG1 kappa monoclonal antibody covalently bound to tiuxetan (MX-DTPA), which stably chelates yttrium-90 for therapy. Ibritumomab tiuxetan therapy involves pretreatment with