gebhart/patrepeval huggingface dataset:
Opioid-Induced Hypogonadism in the United States (2019)

Prolonged opioid exposure was associated with increased rates of screening, diagnosis, and treatment for opioid-induced hypogonadism, but these rates were much lower than expected based on previous serum-based studies.
Coaxial Wiring Structures in Printed Circuit Boards (2008)

We have developed a printed circuit board (PCB) technology with coaxial wiring structures. The coaxial PCB was designed for a prototype model in order to verify the high frequency and high-speed signal transmission characteristics of the coaxial wiring, where high frequency low loss dielectric material was used as insulation layer. It was fabricated by buildup PCB process, additionally using NC end mill router to make a vertical shielding wall electrode. The high frequency measurement of the fabricated coaxial PCB was carried out by the time domain reflectometry (TDR) measurement and the time domain transmission (TDT) measurements. The characteristic impedances of the coaxial wiring lines were evaluated using a TDR waveform analyzer. The average characteristic impedance was controlled within 54 Omega plusmn 3.7 %. The S-parameters were calculated from TDR/TDT measurement results. The insertion loss was measured to be less than 2.3 dB/cm at 10 GHz. Coaxial via structure was investigated for future multilayer coaxial PCB.
La récupération de l'énergie de la houle, partie 1 : caractérisation de la ressource et bases de l'hydrodynamique (2009)

National audience
Le récepteur de l’apeline (2015)

The APJ receptor cloned in 1993 found its ligand in 1998 with the discovery of apelin. The presence of APJ in the central nervous system (more particularly in the hypothalamus) and in various tissues (heart, blood vessels, stomach, etc.) makes it a potential pharmacological target. Interest in APJ has allowed the development of peptidic molecules able to stimulate and/or inhibit the receptor and, more recently, to discover another endogenous ligand: apela. Among the functions regulated by the APJ/apelin system, the control of energy metabolism appears today in the forefront. A better understanding of the pharmacology of APJ receptor should allow innovative therapeutic approaches in the treatment of metabolic diseases.
p‐ and n‐Type Bipolar Redox‐Active Radical Polymer: Toward Totally Organic Polymer‐Based Rechargeable Devices with Variable Configuration (2010)

The p- and n-type bipolar redox-active radical polymer with a nitronylnitroxyl group, poly(nitronylnitroxylstyrene), expands its utilization as a cathode- or anode-active material in organic polymer-based rechargeable devices with two unprecedented configurations: a poleless battery and a “rocking-chair type” battery. These batteries exhibit remarkably high power rate capability (chargeable within 20 s) and high cycle performance.
Remote triggering of air-gap discharge by a femtosecond laser filament and postfilament at distances up to 80 m (2021)

We experimentally observed laser-induced remote high-voltage discharge triggering between two needle electrodes with half-a-cm spacing. The discharge was initiated by a 744-nm, 90-fs, 6-mJ laser pulse undergoing filamentation in air. For the direct voltage below the self-breakdown threshold, triggering of air-gap discharge was synchronized with a 10-Hz laser repetition rate and occurred between 40 and 80 m of the propagation path. No discharge guiding was observed. The experimentally registered and simulated remote triggering probability was above 80% in the range of 45–60 m from laser output and about 50% in the range of 60–80 m. The probability decreases as the postfilament hot spot diverges with a simultaneous increase in stochastic laser beam wandering.
Tumor necrosis factor-α and CD40L modulate cell surface morphology and induce aggregation in Ramos Burkitt's lymphoma cells (2005)

Interaction of CD40L and its cognate receptor is an essential component of B-lymphocyte signaling, affecting various aspects of B-cell differentiation pathways and immunoglobulin gene expression. However, much less is known about the biological consequences of B-cell signaling through tumor necrosis factor (TNF)-alpha and its cognate receptors TNF-R1 and 2. We used Ramos Burkitt's lymphoma cell line as a model system to study the direct effects of these cytokines on B cells. Treatment of Ramos cells with either TNF-alpha or CD40L, but not with interleukin (IL)- 4, interferon (IFN)-gamma and transforming growth factor (TGF)-beta, resulted in enhanced cell aggregation and enhancement of adherence to glass cover-slips. Scanning electron microscopy showed that Ramos cells have a polarized cell surface morphology and exhibit at least 3 cell surface morphological domains: microvilli, filopodia and ruffled membranes. The cells adhered to the glass matrix through multiple filopodia/podopodia-like cell processes and demonstrated distinct ruffled-like membrane projections on their opposite pole. Induction by TNF-alpha or CD40L, but not with IL-4, IFN-gamma and TGF-beta, resulted in increased number and complexity of both types of membrane projections. TNF-alpha and CD40L upregulated the expression of the adhesion molecule intercellular adhesion molecule-1 and the Fas receptor on Ramos cells, without affecting the expression levels of membrane immunoglobulin M or its secretion rate. Reverse transcriptase-polymerase chain reaction, and flow cytometry demonstrated that Ramos cells expressed TNF-R1 but very little if any TNF-R2, indicating that TNF-alpha exerted its effects on Ramos cells through the former receptor.
Measurement of Energy Correlations of Photon Pairs Generated in Silicon Ring Resonators (2015)

With unprecedented resolution we measure the joint spectral density of photon pairs that would be generated by spontaneous four-wave-mixing in a silicon ring resonator, and show how the quantum correlations can be tailored.
The Aiolos transcription factor is up-regulated in chronic lymphocytic leukemia (2008)

The Aiolos transcription factor, member of the Ikaros family of zinc finger proteins, plays an important role in the control of mature B lymphocyte differentiation and proliferation, and its function appears to be modulated through alternative splicing. To assess Aiolos isoform role in humans' pathologies, we studied Aiolos variant distribution and expression in mature B lymphoproliferative disorders (chronic lymphocytic leukemia [CLL] and other B-cell lymphomas). We demonstrated that more than 80% of expressed Aiolos in normal as well as in malignant B cells is of the hAio1 type, and we showed for the first time a homogeneous overexpression of the total amounts of Aiolos transcripts in the B cells of CLL patients, independently of ZAP-70 and IgV(H) mutational status prognosis factors. This up-regulation of Aiolos, confirmed at protein level, seems independent of Aiolos promoter H3K9 acetylation and H3K4 trimethylation.
Viewing interprofessional collaboration through the lens of networked ecological systems theory (2022)

Interprofessional collaboration (IPC) is key to ensuring safe quality care for patients. However, IPC intervention outcomes are variable, leading to calls for systems theories to understand complex interactions in healthcare. Using networked ecological systems theory (NEST), we aimed to uncover facilitators and barriers impacting the interactions between nurses and physicians in a specialty healthcare center. A qualitative study involving 55 non-participant observations and 17 individual semi-structured interviews was conducted at the National Neuroscience Institute of Singapore from April 2019 to March 2021. Template analysis was used to analyze the data. The most important IPC facilitators were exosystemic institutional support and physicians' willingness to engage in IPC in the microsystems that together enabled the establishment of disease-based outpatient programs fostering patient-centered interactions among different healthcare professionals (HCP). We also found that patient-, disease-, and systems-related knowledge played an important role in facilitating IPC. Macrosystemic entrenchments such as intraprofessional composition of ward rounds emerged as a significant barrier. However, microsystemic efforts such as chat groups connecting all HCP involved in the care of the patients in the wards have fostered IPC. Although still preliminary, these findings suggest NEST can be useful to inform systematic interventions to improve IPC.
Diversity Outbred Mice Reveal the Quantitative Trait Locus and Regulatory Cells of HER2 Immunity (2020)

The genetic basis and mechanisms of disparate antitumor immune response was investigated in Diversity Outbred (DO) F1 mice that express human HER2. DO mouse stock samples nearly the entire genetic repertoire of the species. We crossed DO mice with syngeneic HER2 transgenic mice to study the genetics of an anti-self HER2 response in a healthy outbred population. Anti-HER2 IgG was induced by Ad/E2TM or naked pE2TM, both encoding HER2 extracellular and transmembrane domains. The response of DO F1 HER2 transgenic mice was remarkably variable. Still, immune sera inhibited HER2+ SKBR3 cell survival in a dose-dependent fashion. Using DO quantitative trait locus (QTL) analysis, we mapped the QTL that influences both total IgG and IgG2(a/b/c) Ab response to either Ad/E2TM or pE2TM. QTL from these four datasets identified a region in chromosome 17 that was responsible for regulating the response. A/J and NOD segments of genes in this region drove elevated HER2 Ig levels. This region is rich in MHC-IB genes, several of which interact with inhibitory receptors of NK cells. (B6xA/J)F1 and (B6xNOD)F1 HER2 transgenic mice received Ad/E2TM after NK cell depletion, and they produced less HER2 IgG, demonstrating positive regulatory function of NK cells. Depletion of regulatory T cells enhanced response. Using DO QTL analysis, we show that MHC-IB reactive NK cells exert positive influence on the immunity, countering negative regulation by regulatory T cells. This new, to our knowledge, DO F1 platform is a powerful tool for revealing novel immune regulatory mechanisms and for testing new interventional strategies.
Coexistence of Amorphous and Crystalline Calcium Carbonate in Skeletal Tissues (2003)

We describe a new type of composite skeletal tissues in which calcite and stabilized amorphous calcium carbonate (ACC) coexist in well-defined domains. The organisms that form such structures are widely separated in the animal kingdom phylogenetic tree: calcareous sponges and ascidians. This paper compares the microstructures of their composite skeletal elements: The triradiate spicules from the sponge Clathrina are composed of a core of calcite embedded in a thick layer of ACC and covered by a thin calcitic envelope; the tunic spicules from the ascidian Pyura pachydermatina are composed of a core of ACC enveloped by an insoluble organic sheath and covered by a thick calcitic layer. We compare and contrast the macromolecules associated with different amorphous and crystalline phases and their ability to induce the formation of stabilized ACC in vitro.
Ion-Selective Optical Sensors: A New Look at Well-Established Techniques of Signal Acquisition (2018)

It is demonstrated for the first time that the registration of the optode signal under nonequilibrium conditions reduces analysis time and shifts the sensor working range. The fabrication of optode-like color standards for digital color analysis (DCA) is described, and a multi-parameter color scale for calibration-free sensor arrays is proposed. Advantages and limitations of monochrome and color camera for DCA with colorimetric optodes are discussed.
Metal Complexes of a Novel Achiral Symmetric Pentadentate Ligand − Crystal Structures of Monohelical Zinc(II) and Cadmium(II) Complexes (2003)

Abstract By both electrochemical synthesis and a traditional chemical procedure the interaction of the pentadentate ligand 2,6‐bis{1‐[2‐(tosylamino)phenylimino]ethyl}pyridine (H 2 DAPATs), with Mn II , Fe II , Co II , Ni II , Cu II , Zn II and Cd II gives rise to neutral mononuclear complexes that have been characterised by elemental analyses, FAB mass spectrometry, IR, 1 H and COSY NMR spectroscopy and magnetic measurements, where appropriate. Recrystallisation of the zinc complex obtained electrochemically yielded single crystals of [Zn(DAPATs)] ( 1 ), while recrystallisation of cadmium complexes obtained by both techniques afforded the same structure, [Cd(DAPATs)(H 2 O)] ( 2 ). Both 1 and 2 are monohelical single‐stranded compounds with different coordination geometries. In the zinc complex, the metal ion assumes a distorted trigonal‐bipyramidal geometry involving the N 5 atoms of the dianionic ligand. For cadmium complexes the metal ion is in a distorted pentagonal‐pyramidal environment, as the result of coordination to the N 5 ligand donor set and an additional water molecule. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2003)
Structure-Property Studies on a Series of Polycarbonate-Polydimethylsiloxane Block Copolymers (1980)

Abstract Block copolymers composed of hard and soft segments form an interesting class of materials ranging from thermoplastics to thermoplastic elastomers depending on their composition and/or the size of segments. These materials have attracted much attention in the past decade because by careful tailoring, polymers of desired properties can be obtained. Yet they are thermoplastic in nature and can be processed and even reprocessed thermally. Among the common elastomers that can be used as the soft segment in a block copolymer, polydimethyl-siloxane is of special interest due to its great thermal stability at elevated temperatures and high flexibility at low temperatures. Block copolymers containing polydimethylsiloxane as the soft segment and various thermoplastics such as poly(α-methylstyrene), polystyrene, and polysulfone, etc., as the hard segment, have been synthesized and studied. A group of randomly alternating block copolymers of bisphenol-A polycarbonate and polydimethylsiloxane have also been prepared by in situ polymerization of dichloro-terminated siloxane oligomers and bisphenol-A and phosgene. The properties of these block copolymers as well as those of the others have been discussed to some extent in a general review. This work reports the results of a study on the structure-property relationship of a series of perfectly alternating block copolymers of bisphenol-A polycarbonate and polydimethylsiloxane synthesized via different routes. They were prepared by silylamine-hydroxyl reaction. Slightly less than the stoichiometric quantity of siloxane oligomers was incrementally added to a hydrated solution of the polycarbonate in refluxing chlorobenzene. The reaction can be represented by the simple scheme:
ChemInform Abstract: Homogeneous Catalysis in Supercritical Carbon Dioxide: A Better Solution? (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The structural and functional role of myelin fast-migrating cerebrosides: pathological importance in multiple sclerosis (2011)

A family of neutral glycosphingolipids containing a 3-O-acetyl-sphingosine galactosylceramide (3-SAG) has been characterized. Seven new derivatives of galactosylceramide (GalCer), designated as fast-migrating cerebrosides (FMCs) by TLC retention factor, have been identified. The simplest compounds - FMC-1 and FMC-2 - of this series have been characterized as the 3-SAG containing nonhydroxy and hydroxy fatty acyl, respectively. The next two - FMC-3 and FMC-4 - add 6-O-acetyl-galactose and the most complex glycosphingolipids, FMC-5, -6 and -7, are 2,3,4,6-tetra-O-acetyl-3-SAG. These hydrophobic myelin lipid biomarkers coappear with GalCer during myelinogenesis and disappear along with GalCer in de- or dys-myelinating disorders. Myelin lipid antigens, including FMCs, are keys to myelin biology, opening the possibility of new and novel immune modulatory tools for treatment of autoimmune diseases including multiple sclerosis.
Reliability improvement of IGZO‐TFT in hybrid process with LTPS (2021)

Abstract An AMOLED panel using hybrid backplane technology based on p‐type low temperature polycrystalline silicon (p‐LTPS) and n‐type indium–gallium–zinc–oxide (n‐IGZO) thin‐film transistors (TFTs) has been successfully manufactured. New pixel and Gate‐on‐Array (GOA) circuits were designed and fabricated using this technology. GOA with CMOS inverter is realized by utilizing both IGZO and p‐LTPS. The hybrid backplane AMOLED panel can operate between 1 and 120 Hz, which enables both high refresh rate and low standby power display applications. Furthermore, the AMOLED panel lifetime has markedly enhanced by improving IGZO TFT's uniformity and reliability.
Compact analytical models for the SET and RESET switching statistics of RRAM inspired in the cell-based percolation model of gate dielectric breakdown (2013)

In this work, we depart from the cell-based percolation model of gate dielectric breakdown (BD) to propose analytical models for the SET and RESET statistics in resistive switching memory (RRAM). The SET or RESET statistics model consists of two basic elements: (i) a cell-based geometrical model to describe the dependence of the resistive switching (RS) distribution on the defect generation in the conductive filament (CF), and (ii) a deterministic model for the SET/RESET dynamics to describe the relation of the defect generation with measurable variables such as the SET/RESET voltage and current. The experimental observations in HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> - and NiO-based RRAM devices can be successfully accounted for by our models for RS statistics. The models set a framework for the consideration of performance-reliability tradeoffs in RRAM.
Chemical Tools for Dissecting Bacterial Physiology and Virulence (2009)

Increasingly, chemical biology is being used in the context of bacterial virulence and the host-pathogen interaction, as small molecule inhibitors provide a number of unique advantages for the study of bacterial pathogens that complement powerful, existing classical genetic approaches. Small molecules have the potential to inhibit targets rapidly and reversibly, with a high degree of specificity. They are therefore well suited for studying the role of essential genes in bacterial physiology and virulence in both genetically tractable and intractable organisms, with the capacity to reveal novel phenotypes and insights into the function of essential factors during infection. The use of small molecule inhibitors during infection is also deepening our understanding of the role that host factors play in bacterial pathogenesis. In the future, the utility of chemical biology will grow as technologies for rapid identification of targets of interesting bioactive small molecules are developed. In this review, we highlight recent work in which small molecule inhibitors are used to study essential genes and genetically intractable organisms, to reveal novel phenotypes related to bacterial physiology, and to probe the role of bacterial and host factors during infection. In addition, we review recent advances in biochemical, genetic, and genomic techniques for target identification.
Structure-Based Virtual Screening (2011)

The number of promising macromolecular targets involved in drug discovery programs has considerably increased because of the recent advances in human genomics and proteomics. In this respect, modern techniques like virtual screening in combination with high-throughput screening are well established approaches to assist identification of novel lead compounds. In particular, structure-based virtual screening is widely applied to search for new hit molecules among a large number of chemical compounds against therapeutically relevant protein targets with known three-dimensional structures. Here, we introduce the main techniques and programs applied for structure-based virtual screening with a focus on the molecular docking–scoring methodology and we discuss key issues that still need to be improved. In addition, we give recent examples of successful applications of hierarchical structure-based virtual screening methods combined with ligand-based ones.
A 12-element 60GHz CMOS phased array transmitter on LTCC package with integrated antennas (2011)

A 12-element 60GHz phased array transmitter sys-tem-in-package intended for multi-Gbps wireless communications is presented. The system-in-package (SIP) comprises of a CMOS IC and aperture coupled microstrip patch antennas integrated on a low temperature co-fired ceramic (LTCC) package. The IC includes distribution network for 60GHz signals, phase shifters, pre-drivers and PAs. The SIP has been tested using wafer-probing, package-probing and on-the-air measurements including the antennas. The experimental results have been compared extensively against simulations to check the validity of the modeling and experimental methodologies used. The phased-array achieves 21-dB of beam forming gain in line with theoretical expectation. Non-idealities, for example at the RFIC-package interface, have been discussed and modeled due to their importance for mm-wave systems-in-package.
The Explicit Planetary Isentropic-Coordinate (EPIC) Atmospheric Model (1998)

We describe a new general circulation model (GCM) designed for planetary atmospheric studies called the EPIC model. This is a finite-difference model based on the isentropic-coordinate scheme of Hsu and Arakawa (1990.Mon. Wea. Rev.118, 1933–1959). We report on previously undocumented modifications, additions, and key practical issues that experience running the model has revealed to be important. The model integrates the hydrostatic primitive equations, which are valid for large-scale atmospheric dynamics and include gravity waves (buoyancy waves), planetary waves (Rossby waves), and horizontally propagating sound waves (Lamb waves), but not vertically propagating sound waves because of the hydrostatic approximation. The vertical coordinate is entropy in the form of potential temperature, which coincides with material surfaces for adiabatic motion. This means that there is no vertical velocity except where there is heating, which improves accuracy and helps the model maintain conservation properties over long integrations. An isentropic vertical coordinate is natural for the atmospheres of Jupiter, Saturn, Uranus, and Neptune, which are believed to have essentially adiabatic interiors that match up with the bottom of the model and is also excellent for middle-atmosphere studies on any planet. Radiative processes are parameterized by Newtonian cooling, and the latent heat of ortho–para hydrogen conversion is included when appropriate, with a suitably defined mean potential temperature. The model is written with general map factors that make it easy to configure in oblate spherical, cylindrical, or Cartesian coordinates. The code includes optional Message Passing Interface (MPI) library calls and hence runs on any Unix-based parallel computer or network cluster. An optional graphical user interface to commercial visualization software facilitates control of the model and analysis of output. Memory is allocated dynamically such that the user does not recompile to change horizontal or vertical resolution or range. Applications to date include comet impact forecasts and hindcasts for Jupiter, meridional circulation studies of Uranus and Neptune, and the accompanying paper on three-dimensional simulations of Neptune's Great Dark Spot (1998.Icarus132, 239–265).