gebhart/patrepeval huggingface dataset:
Personalized Integrative Oncology: Targeted Approaches for Optimal Outcomes (2014)

The 11th International Conference of the Society for Integrative Oncology (SIO) brought together more than 300 clinicians, researchers, patients, and advocates to hear and interact with world-leading experts about the latest research in the areas of nutrition, exercise, acupuncture, health services research, meditation, and other integrative disciplines. The conference theme, "Personalized Integrative Oncology: Targeted Approaches for Optimal Outcomes," highlighted innovations in personalized medicine and ways this growing field will advance the evolution of individualized integrative cancer care to the next level. This year's conference also featured a clinical track focusing on clinical information for the practicing health care professional. The conference's rigorous schedule included 3 keynotes, 4 plenary sessions, 2 interdisciplinary tumor boards, 5 workshops, 45 concurrent oral sessions, and 106 posters. In addition to the conference theme, keynote and plenary sessions presented topics on stress and cancer, the importance of sleep for cancer patients, epigenetic mechanisms of lifestyle and natural products, recently published Journal of the National Cancer Institute monograph on integrative oncology, SIO's clinical practice guidelines for breast cancer survivors, and a joint session of the American Academy of Hospice and Palliative Medicine and SIO about supportive care and symptom management. This highly successful conference helped further the mission of the SIO to advance evidence-based, comprehensive, integrative health care to improve the lives of people affected by cancer.
Bromopyrrole Alkaloids from Marine Sponges of the Genus Agelas (2009)

Four new bromopyrrole alkaloids, nagelamides O (1) and P (2) and mukanadins E (3) and F (4), were isolated from three collections of Okinawan marine sponges of the genus Agelas. The structures and stereochemistry of 1-4 were elucidated on the basis of their spectroscopic data.
AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation (2009)

Circadian clocks coordinate behavioral and physiological processes with daily light-dark cycles by driving rhythmic transcription of thousands of genes. Whereas the master clock in the brain is set by light, pacemakers in peripheral organs, such as the liver, are reset by food availability, although the setting, or "entrainment," mechanisms remain mysterious. Studying mouse fibroblasts, we demonstrated that the nutrient-responsive adenosine monophosphate-activated protein kinase (AMPK) phosphorylates and destabilizes the clock component cryptochrome 1 (CRY1). In mouse livers, AMPK activity and nuclear localization were rhythmic and inversely correlated with CRY1 nuclear protein abundance. Stimulation of AMPK destabilized cryptochromes and altered circadian rhythms, and mice in which the AMPK pathway was genetically disrupted showed alterations in peripheral clocks. Thus, phosphorylation by AMPK enables cryptochrome to transduce nutrient signals to circadian clocks in mammalian peripheral organs.
40-Gb/s WDM transmission with virtually imaged phased array (VIPA) variable dispersion compensators (2002)

We have demonstrated variable dispersion compensation by using a virtually imaged phased array (VIPA) to overcome the small dispersion tolerance in 40-Gb/s dense wavelength-division multiplexing (WDM) transmission systems. By utilizing the periodical characteristics of VIPA compensators, we performed simultaneous dispersion compensation in a 1.28-Tb/s (40-Gb/s/spl times/32 ch; C band) short-haul transmission and confirmed that only two VIPA compensators and one fixed dispersion-compensating fiber are required for a large transmission range of 80 km. This performance can greatly reduce the cost, size, and number of compensator menus in a 40-Gb/s WDM short-haul transmission system. In addition, we achieved 3.5-Tb/s (43-Gb/s/spl times/88 ch; C and L bands) transmission over a 600-km nonzero dispersion-shifted fiber by using VIPA compensators. Although channel-by-channel dispersion compensation is required due to the larger residual dispersion slope in long-haul transmission, the periodical characteristics of the VIPA compensators offer the advantage of considerably reducing the number of different modules required to cover the whole C (or L) band. An adequate optical signal-to-noise ratio, which was the same for all channels, was-obtained by using distributed Raman amplification, a gain equalizer, and a preemphasis technique. We achieved a Q-factor of more than 11.8 dB; (BER<10/sup -17/ with forward-error correction) for all 88 channels.
On-Chip Polychromatic visible light emitters obtained by 3D Capillary Force Assembly (2012)

National audience
Integrating First Principles-Based Approaches into the Routine Design Practice for Offshore Consequence Analysis and Operational Troubleshooting Assessments (2019)

Abstract Significant advancements in physics-based model development, software workflow practices, multi-core processing and cost-effective cloud computing has enabled the adoption of high fidelity, three-dimensional (3D) modeling such as computational fluid dynamics (CFD), finite element analysis (FEA), and other first principles-based analyses into normal engineering design practices. Historically, integration of these tools into the standard engineering workflow was challenging due to the excessively long turnaround times to deliver any results. Three Case Studies are subsequently presented where 3D modeling analysis was used early and seamlessly in the engineering design process to solve problems related to consequence analysis and equipment operational performance: Case 1) Risk assessment of pilot flame extinguishment due to inert gas discharge from the flare of an FPSO, Case 2) Jet dispersion analysis from HP/LP flare to assess hydrocarbon and H2S concentrations at critical locations on the platform, including results comparison between CFD results and a conventional dispersion tool – Flaresim, and, Case 3) Solving a fatigue induced cracking problem on the cooling water circuit of a heat exchanger using an integrated workflow consisting of CFD modelling of the cooling water, stress analysis using FEA, and structural integrity assessment per ASME BPVC VIII Division 2. The modelling results from these case studies were generated in timeframes similar to those using conventional engineering calculation methods, and thus allowed for prompt integration into the engineering design process without impacting project schedules and delivery. Moreover, the costs to perform these modelling analyses were not substantially greater than the costs associated with conventional calculation methods, thereby providing high value to the engineering projects.
Kaposi’s sarcoma in the grafted lung (2016)

The paper provides a clinical note. A 45-year-old patient suffered from severe primary emphysema and underwent bilateral lung transplantation. A year after surgery, exercise dyspnea again appeared in the patient. Lung computed tomography revealed multiple rounded soft tissue masses; thoracoscopic biopsy and further histological examination proved the development of Kaposi's sarcoma in the patient. The tumor disappeared completely following corrected immunosuppressive therapy. After 22 months of transplantation, the patient died from gastrointestinal bleeding. This case is of interest due to that Kaposi's sarcoma develops extremely rarely in the allogeneic lung after its transplantation.
Toward a Better IPA Experience for a Connected Vehicle by Means of Usage Prediction (2019)

Recently, a connected vehicle comes into wide use. A connected vehicle enables seamless access from outside of the vehicle. A user can easily control the vehicle remotely as if it is a home appliance device. IPA (Intelligent Personal Assistants) or smart speaker adoption is growing rapidly these years. We have already released an IPA application for remote control of a vehicle to enhance accessibility of our connected vehicle. Since the launch, we found significant drop of users from using application, which is reportedly caused by social or mental obstacles to use IPA in some researches. To mitigate these obstacles, we propose proactive suggestion by IPA. We apply a vehicle usage prediction model on our connected vehicle data. The prediction enable spontaneous suggestion by IPA, therefore the user doesn't need to speak wake- up word. In our model, firstly LDA automatically discover usage patterns and clustering method on the latent space. The result suggests some user segments which represent habitual vehicle usage. The prediction is performed by dynamic Bayesian networks for each user segment. An evaluation with actual service data confirms applicability of the prediction model and potential of IPA log itself can also assist vehicle usage prediction.
Neurogenetics (2015)

To an increasing extent, the desire to catalog and categorize neurologic disorders based on genotype–phenotype correlations is challenged by frequent departures from the syndromic categorizations that were commonplace in the pregenomic era. This challenge is not limited to the recent striking revelations concerning diseases attributable to noncoding, nonconventional mutations, such as repeat expansions in C9ORF72 . There are abundant examples of conventional mutations, identified using nonbiased, whole-exome sequencing, that lead to unanticipated phenotypes in the world of hereditary motor system disorders. The report by Pfeffer et al.1 further the supports the idea that, as targeted sequencing based on clinical phenotype moves toward nonbiased sequencing, we must be prepared to expect surprises that link genetic abnormalities to unanticipated clinical syndromes.
Zika Virus Infection Prevents Host mRNA Nuclear Export by Disrupting UPF1 Function (2020)

Abstract Zika virus (ZIKV) is a mosquito-borne RNA virus that can infect fetuses in utero causing characteristic neurodevelopmental disorders including microcephaly. We previously showed that ZIKV infection downregulates expression of up-frameshift protein 1 (UPF1), a helicase/ATPase and central regulator of the nonsense-mediated mRNA decay pathway. Here, we identify a novel function of nuclear UPF1 in mRNA export. Using crosslinking immunoprecipitation of UPF1 followed by sequencing of associated transcripts as well as fluorescence in situ hybridization experiments, we find widespread mRNA accumulation in the nucleus of human neural progenitor cells (NPCs) upon ZIKV infection or UPF1 knockdown. Knockdown of FREM2 , a top UPF1 target transcript encoding an extra-cellular matrix protein critical in fetal development, decreased expression of pluripotency markers and increased expressed neuronal differentiation in NPCs, consistent with the model that trapping FREM2 mRNA in the nucleus perturbs proper NPC function. Collectively, our data uncover a new posttranscriptional mechanism by which ZIKV “shuts off” host mRNA export via UPF1. As we find UPF1 linked to many neurodevelopment pathways, we propose that the lack of host mRNA export contributes to the neurodevelopmental defects associated with ZIKV infection.
Technique for Staining Leafhopper (Homoptera: Cicadellidae) Salivary Sheaths and Eggs Within Unsectioned Plant Tissue (1988)

A technique that allows the staining and observation of whole leafhopper salivary sheaths left behind in plant tissue is described. A derivation of McBride’s acid fuchsin stain for fungal hyphae was used, followed by clearing of the plant tissue for observation under a dissecting microscope. Data gathered included the shape and location of sheaths, and the orientation of sheaths to veins. The technique simultaneously stained eggs present ill the plant tissue. Thus, measures of both feeding and oviposition were acquired from the same plant. This method is reliable in recovering known sheaths and is applicable to several hemipteran sheath-feeders. The method should be useful to researchers studying host plant resistance and other aspects of the feeding of haustellate insects.
Pre-mRNA Splicing Mechanisms, Misregulation in Disease, and Therapeutic Strategies (2012)

Abstract Abstract SCI-13 Most eukaryotic protein-coding genes have one or more introns, and their transcripts can undergo alternative splicing, giving rise to multiple isoforms. Accurate splicing is essential for normal gene expression, and alternative splicing is a key mechanism for expanding the proteome and regulating the expression of diverse protein isoforms. This session will review the general mechanisms of pre-mRNA splicing and the regulation of alternative splicing. In addition, the process of how abnormal splicing arises as a result of intronic or exonic mutations in particular genes, or more globally as a result of splicing-factor misregulation, as well as the contribution of splicing misregulation to cancer, will be described. Lastly the current status of targeted therapeutics development, focusing on antisense approaches to correct abnormal splicing of specific genes or to modulate alternative splicing, will be discussed. Disclosures: Krainer: ISIS Pharmaceuticals: Consultancy, Patents &amp; Royalties, Research Funding.
Structure Formation in Metal Complex/Polymer Hybrid Nanomaterials Prepared by Miniemulsion (2011)

Polymer/complex hybrid nanostructures were prepared using a variety of hydrophobic metal β-diketonato complexes. The mechanism of structure formation was investigated by electron paramagnetic resonance (EPR) spectroscopy and small-angle X-ray scattering (SAXS) in the liquid phase. Structure formation is attributed to an interaction between free coordination sites of metal β-diketonato complexes and coordinating anionic surfactants. Lamellar structures are already present in the miniemulsion. By subsequent polymerization the lamellae can be embedded in a great variety of different polymeric matrices. The morphology of the lamellar structures, as elucidated by transmission electron microscopy (TEM), can be controlled by the choice of anionic surfactant. Using sodium alkylsulfates and sodium dodecylphosphate, "nano-onions" are formed, while sodium carboxylates lead to "kebab-like" structures. The composition of the hybrid nanostructures can be described as bilayer lamellae, embedded in a polymeric matrix. The metal complexes are separated by surfactant molecules which are arranged tail-to-tail; by increasing the carbon chain length of the surfactant the layer distance of the structured nanomaterial can be adjusted between 2 and 5 nm.
Solid-State NMR Study of New Copolymers as Solid Polymer Electrolytes (2018)

We report the analysis of comb-like polymers by solid-state NMR. The polymers were previously evaluated as solid-polymer-electrolytes (SPE) for lithium-polymer-metal batteries that have suitable ionic conductivity at 60 °C. We propose to develop a correlation between 13C solid-state NMR measurements and phase segregation. 13C solid-state NMR is a perfect tool for differentiating polymer phases with fast or slow motions. 7Li was used to monitor the motion of lithium ions in the polymer, and activation energies were calculated.
Polymer-Filled Nematics: A New Class of Light-Scattering Materials for Electro-Optical Switches (2000)

A new class of mixtures of liquid-crystalline (LC) materials and polymersis presented, consisting of sub-micrometer sized, internally crosslinked polymeric particles (see Figure) dispersed in a continuous (completely phase-separate) LC phase. Initial electro-optical experiments with these “polymer-filled nematics” indicate that their light-scattering properties can be controlled with the application of an electrical field.
Service Usage Reporting System for Optimal Transmission of Broadcast Services in 5G-Broadcast Converged Networks (2023)

This paper presents a method for generating service usage information for broadcasting services at the receiver side in 5G-broadcast converged networks. The study aims to establish a system for collecting and transmitting service usage information to optimize the transmission of broadcasting services in a 5G and broadcast converged network environment, providing data for network planning and optimization, and enhancing the viewing experience. The study concludes with the results of a test conducted to evaluate the proposed method for generating service usage information.
Application of ball bearing cage RF temperature sensor in high speed turbocharger (2014)

The application of a radio frequency ball bearing cage temperature telemeter in a high speed turbocharger is demonstrated. A temperature dependent LC tank circuit is adhered to the bearing cage and wirelessly monitored using an axially displaced stationary receiver coil. The cage sensor is installed in a turbocharger rotor-bearing system and is able to withstand the harsh conditions of being tested at speeds up to 77,000 r/min. The sensor tracks the transient temperature response within the bearing due to mechanical losses and external heating. This sensor concept may be utilized to monitor bearing performance at high speeds, detect loss of lubricant and impending failure, and implement predictive analytics using measured data.
Front Matter: Volume 8823 (2013)

This PDF file contains the front matter associated with SPIE Proceedings Volume 8823, including the Title Page, Copyright information, Table of Contents, Introduction, and Conference Committee listing.
Supplementary Figure 1 from <i>TMPRSS2-ERG</i> Status Is Not Prognostic Following Prostate Cancer Radiotherapy: Implications for Fusion Status and DSB Repair (2023)

&lt;p&gt;Supplementary Figure 1 - PDF file 49K, Schematic representation of TMPRSS2-ERG fusion allele in the chromosome 21q22.2/21q22.3. Gene positions are based on NCBI36/hg18 human genome reference&lt;/p&gt;
Targeting and Anchoring of Munc13-1 and ubMunc13-2 to active zones by RIM1alpha (2005)

Members of the Unc-13/Munc13 protein family are components of the presynaptic active zone and essential vesicle priming factors in regulated exocytosis. They are thought to mediate vesicle priming by stabilizing the open conformation of the Q-SNARE Syntaxin, thereby promoting the SNARE core complex assembly. The Unc-13/Munc13 protein family is evolutionarily highly conserved and comparison of the various Unc-13 homologs in different species demonstrates that the respective genes consist of two modules that have evolved differentially and may have independent functional roles. The carboxy-terminal two-thirds of the protein are highly conserved between Drosophila, C. elegans, mouse, rat, and human, whereas of the known mammalian Unc-13 homologs, only Munc13-1 and ubMunc13-2 contain an amino-terminus with homology to the Unc-13 L region of C. elegans. RIM is an active zone protein, that has been found to bind this conserved amino-terminus of Munc13-1 and ubMunc13-2 and has been! proposed to act at multiple steps of the synaptic vesicle cycle, including targeting/docking, priming and fusion of synaptic vesicles. In the present study, we used a random mutagenesis approach in combination with yeast two-hybrid technology, biochemical assays as well as immunocytochemistry to identify residue(s) in the Munc13-1/ubMunc13-2 sequence that are critical for RIM binding. The ultimate aim of these studies is to develop the basis for subtle genetic interference with the RIM/Munc13-interaction in mice, which will allow a detailed functional characterization of this synaptic regulatory protein-protein interaction.
Adaptive wavefront control with asynchronous stochastic parallel gradient descent clusters (2006)

A scalable adaptive optics (AO) control system architecture composed of asynchronous control clusters based on the stochastic parallel gradient descent (SPGD) optimization technique is discussed. It is shown that subdivision of the control channels into asynchronous SPGD clusters improves the AO system performance by better utilizing individual and/or group characteristics of adaptive system components. Results of numerical simulations are presented for two different adaptive receiver systems based on asynchronous SPGD clusters-one with a single deformable mirror with Zernike response functions and a second with tip-tilt and segmented wavefront correctors. We also discuss adaptive wavefront control based on asynchronous parallel optimization of several local performance metrics-a control architecture referred to as distributed adaptive optics (DAO). Analysis of the DAO system architecture demonstrated the potential for significant increase of the adaptation process convergence rate that occurs due to partial decoupling of the system control clusters optimizing individual performance metrics.
Inflammation and Atherosclerosis—Revisited (2013)

Atherogenesis has been traditionally viewed as a metabolic disease representing arterial obstruction by fatty deposits in its wall. Today, it is believed that atherogenesis involves highly specific biochemical and molecular responses with constant interactions between various cellular players. Despite the presence of inflammatory reaction in each and every step of atherosclerosis from its inception to terminal manifestation, the cause--effect relationship of these 2 processes remains unclear. In this article, we have attempted to review the role of inflammation in the development of atherosclerosis and in its major complication--coronary heart disease.
Evaluation of Driver’s Sense of Control in Lane Change Maneuvers with a Cooperative Steering Control System (2021)

Balancing safety and comfort is an important requirement in highly automated driving. In order to achieve safe and comfortable transportation using automated driving technology, cooperative driving, in which the driver and the system work together on the common driving task, may be more effective than a system that completely replaces the driver. Therefore, in this research, we address a cooperative driving system that provides steering assistance and steer-angle regulation based on force-feedback and steer-by-wire systems. We evaluate the safety and comfort of the system through a simulated driving study under different levels of system intervention in lane change maneuvers. Experimental results show that steer-angle regulation without force feedback gives the highest sense of control (involvement in driving) to drivers, although the driving maneuver is overridden by the system to maintain safety in the current condition.