gebhart/patrepeval huggingface dataset:
A repetitive microsecond pulse generator for atmospheric pressure plasma jets (2015)

Compared with other non-thermal plasma sources, the atmospheric-pressure plasma jet (APPJ) has advantages on simple structure, low temperatures, strong chemical activities, and convenient handling, all of which have attracted much attention. The power sources play an important role on the characteristics and the applications of the APPJ. In this article, a compact repetitive microsecond-pulse generator is designed for exciting the APPJ in helium and argon. The microsecond-pulse generator can produce repetitive pulses with output voltages of up to 20 kV, pulse width of ~8 μs, and pulse repetition frequencies (PRFs) of 1 Hz ~2 kHz. Using the designed repetitive microsecond-pulse generator, the characteristics of the APPJ are investigated by measuring the voltages and currents and obtaining images of the discharges. Experimental results show that the microsecond-pulse generator has been successfully used to sustain stable APPJs both in helium and argon. The shape of the output voltage pulses may change as the applied voltage increases. Nevertheless, the output voltages are stable at all PRFs when the applied voltage is fixed. Furthermore, the effects of flow rate, the applied voltage, and the PRF on the He/Ar APPJ are investigated. Results show that it is more likely to generate a He APPJ rather than an Ar APPJ under microsecond-pulse excitation. The length of the plasma plume is slightly affected by the PRF both in the He APPJ and the Ar APPJ.
On binary alphabetical codes (2003)

Binary alphabetical codes, which are prefix free, fixed-to-variable binary codes for discrete memoryless sources, in which the lexicographic order of the codewords agrees with the alphabet order of the respective source letters, are studied. A necessary and sufficient condition on the sequence of codeword length of any such code is proved. A new upper bounds on the redundancy of alphabetical codes relative to the optimal prefix free, fixed-to-variables codes-the Huffman codes-is proved. An adaptation of the Ziv-Lempel algorithm making it lexicographic order preserving, without any additional redundancy, is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Age Classification of Evacuees at Times of Disaster Using a Vibration Sensor (2020)

In this study, a method to detect children evacuating from a building at the time of a disaster using a vibration sensor is proposed. The features for detection are obtained using linear prediction, which is suitable for analyzing resonance phenomena such as speech. Subsequently, the extracted features are used in the linear discrimination analysis to discriminate between children and adults. Experimental results with 40 subjects show that the detection rate was approximately 80% in the test environment.
In Vivo Antagonism of AhR-Mediated Gene Induction by 3'-Methoxy-4'-nitroflavone in TCDD-Responsive lacZ Mice (2001)

The aryl-hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is a member of the bHLH-PAS family of proteins. The highest-affinity ligand of this receptor is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which is a potent immunological, reproductive, and developmental toxicant. The mechanism of TCDD-induced toxicity and the gene modulations that result in toxicity have not been fully defined. The majority of work to date exploring AhR function has focused on agonist-activated AhR signaling. However, it is expected that a better understanding of AhR antagonism will lead to an improved understanding of TCDD toxicity and other AhR-mediated events. This study contributes to such investigations by utilizing the AhR antagonist 3'-methoxy-4'-nitroflavone (3'M4'NF) and a dioxin-responsive lacZ transgenic mouse model to characterize antagonism of the receptor system in vivo. The dose-response and time course of TCDD-induced transgene activation were evaluated in transgenic mice to provide information necessary to design 3'M4'NF in vivo studies. TCDD induction of the transgene was noted as early as 8 h after exposure in the lung. 3-miccrog/kg body weight TCDD was the lowest dose found to induce the reporter transgene. Finally, experiments were performed to evaluate the in vivo efficacy of 3'M4'NF. We found that 3'M4'NF inhibits TCDD-mediated reporter gene activation and CYP1A1 induction in vivo. Based on these findings, it is clear that DRE-lacZ animals and the antagonist 3'M4'NF represent important tools which will help in the identification of tissues where AhR is active, and to further characterize AhR-mediated signaling.
Pasteurization, development and storage of sous vide rendang (spicy beef stew) (2007)

Abstract This study aims to develop product and processing parameters of sous vide rendang and to examine its quality changes during storage. Sous vide rendang may be pasteurized for 443 min at 75°C and for 88 min at 85°C using fast heating to meet the Pv 90 = 10‐min guideline for pasteurization. Process‐meat‐formulation combinations of sous vide rendang indicated that processing at 85°C/2 h, the use of rump and formulation 1 (F1) produced better sensory properties. Water activity ( A w ), aside from pasteurization, is a possible controlling factor for sous vide (SV) rendang but not pH. Conventionally cooked (CC) rendang stored at 2°C and sous vide rendang pasteurized at 70°C/100 min (SS70) and at 85°C/2 h (SS85) stored at 2 and 10°C can last for 35 days using microbiological count as its storage indicator. Applications of guidelines by the UK Food Standards Agency would mean that the maximum shelf life allowable for CC and SS70 will only be 10 days compared to SS85, which is 40 days.
Influence of age on respiratory modulation of muscle sympathetic nerve activity and blood pressure in humans (2013)

We sought to determine the influence of age on respiratory related bursting of muscle sympathetic nerve activity (MSNA) and the coupling of MSNA to the rhythmic fluctuations in blood pressure (BP) which occur with the respiratory cycle (Traube‐Hering Waves; THW). Recordings of MSNA (microneurography), BP (Finometer) and respiration (pneumobelt) were obtained in 10 young (22±1 yr, mean±SE) and 10 older (58±2 yr) healthy men with a similar BMI (~25 kg/m 2 ), while supine and breathing normally. Following correction for nerve conduction delays, respiratory cycle triggered averaging of MSNA and BP was performed. MSNA burst incidence was higher in older individuals (P&lt;0.05, ANOVA), but similarly reduced in the inspiratory to post‐inspiratory period in young and older subjects (18±3 and 37±5 bursts•100 heart beats −1 ) compared to mid‐to‐late expiration (26±4 and 47±5 bursts•100 heart beats −1 in young and older). A significant positive correlation between MSNA and THW magnitude was observed in 90% of young but only 40% of older subjects. Thus, while the cyclic inhibition of MSNA during respiration is preserved in older individuals, the association between MSNA and THW is less robust. Supported by BHF.
Reaction of Alkylchlorosilanes with Silica: Importance of a Surface Attachment in Defining the Triboelectrification of the Modified Silica (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of Alkylchlorosilanes with Silica: Importance of a Surface Attachment in Defining the Triboelectrification of the Modified SilicaC. P. Tripp, R. P. N. Veregin, M. N. V. McDougall, and D. OsmondCite this: Langmuir 1995, 11, 6, 1858–1859Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/la00006a006https://doi.org/10.1021/la00006a006research-articleACS PublicationsRequest reuse permissionsArticle Views295Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Detection of Stem Cell Transplant Rejection with Ferumoxytol MR Imaging: Correlation of MR Imaging Findings with Those at Intravital Microscopy (2017)

Purpose To determine whether endogenous labeling of macrophages with clinically applicable nanoparticles enables noninvasive detection of innate immune responses to stem cell transplants with magnetic resonance (MR) imaging. Materials and Methods Work with human stem cells was approved by the institutional review board and the stem cell research oversight committee, and animal experiments were approved by the administrative panel on laboratory animal care. Nine immunocompetent Sprague-Dawley rats received intravenous injection of ferumoxytol, and 18 Jax C57BL/6-Tg (Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6) 2Bck/J mice received rhodamine-conjugated ferumoxytol. Then, 48 hours later, immune-matched or mismatched stem cells were implanted into osteochondral defects of the knee joints of experimental rats and calvarial defects of Jax mice. All animals underwent serial MR imaging and intravital microscopy (IVM) up to 4 weeks after surgery. Macrophages of Jax C57BL/6-Tg (Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6) 2Bck/J mice express enhanced green fluorescent protein (GFP), which enables in vivo correlation of ferumoxytol enhancement at MR imaging with macrophage quantities at IVM. All quantitative data were compared between experimental groups by using a mixed linear model and t tests. Results Immune-mismatched stem cell implants demonstrated stronger ferumoxytol enhancement than did matched stem cell implants. At 4 weeks, T2 values of mismatched implants were significantly lower than those of matched implants in osteochondral defects of female rats (mean, 10.72 msec for human stem cells and 11.55 msec for male rat stem cells vs 15.45 msec for sex-matched rat stem cells; P = .02 and P = .04, respectively) and calvarial defects of recipient mice (mean, 21.7 msec vs 27.1 msec, respectively; P = .0444). This corresponded to increased recruitment of enhanced GFP- and rhodamine-ferumoxytol-positive macrophages into stem cell transplants, as visualized with IVM and histopathologic examination. Conclusion Endogenous labeling of macrophages with ferumoxytol enables noninvasive detection of innate immune responses to stem cell transplants with MR imaging. <sup>©</sup> RSNA, 2017 Online supplemental material is available for this article.
Investigation of HIFU-induced anti-tumor immunity in a murine tumor model (2007)

These studies present initial encouraging results confirming that focused ultrasound treatment can elicit a systemic anti-tumor immune response, and they suggest that this immunity is closely related to dendritic cell activation. Because DC activation was more pronounced when tumor cells were mechanically lysed by focused ultrasound treatment, mechanical HIFU in particular may be employed as a potential strategy in combination with subsequent thermal ablations for increasing the efficacy of HIFU cancer treatment by enhancing the host's anti-tumor immunity.
Rapid protein sequencing by the enzyme-thermospray liquid chromatographic/mass spectrometric method (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRapid protein sequencing by the enzyme-thermospray liquid chromatographic/mass spectrometric methodKrystyna. Stachowiak, Cheryl. Wilder, Marvin L. Vestal, and Douglas F. DyckesCite this: J. Am. Chem. Soc. 1988, 110, 6, 1758–1765Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/ja00214a017https://doi.org/10.1021/ja00214a017research-articleACS PublicationsRequest reuse permissionsArticle Views99Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Impact of Lockdown-Related Reduction in Anthropogenic Emissions on Aerosol Characteristics in the Megacity, Bengaluru (2021)

Continuous analytical measurements of the loading and optical properties of near-surface aerosols over the megacity Bengaluru, in south India, are examined for the impact of the national lockdown (LD) associated with COVID-19 pandemic. The near total shutdown of rail, road, and air traffic as well as total closure of most of the business establishments and IT industry, especially during the first phase of the LD, is found to dramatically reduce black carbon (BC) abundance. Within one week of the first week of the LD phase 1 (LD1), the ambient BC concentration at the urban centre came down to levels comparable to those reported for remote rural locations, primarily due to >60% reduction in BC from fossil fuel (BC ff ) emissions. On the other hand, BC from biomass burning (BC wb ) did not show any conspicuous impact. Consequently, the fraction of BC wb to BC more than doubled and the spectral absorption coefficient increased from ~1.15 to ~1.4. The single scattering albedo increased from its prevailing mean value 0.66 before LD to 0.74 during LD1 and then gradually decreased to 0.68 with increasing relaxations on vehicular traffic. The results reveal the unequivocal role of vehicular emissions in impacting the aerosol loading and their optical properties over Bengaluru. The study also shows how the environment responded to the gradual relaxations in the subsequent phases of LD. It is interesting to note that a few spells of strong rainfall towards the fourth phase of the LD impacted the aerosols non-selectively leading to sharp decrease in all the quantities. However, owing to the non-selective nature of the washout this large reduction in loading did not impact the single scattering albedo, unlike the case with the LD.
High-Torque Oscillating Wind Energy Generator (2020)

Abstract This research investigates a novel concept in small-scale wind-energy generation. Instead of rotating turbine blades, the present concept produces reciprocating motion that is achieved by alternately activating boundary layer control (slot blowing) on opposite sides of a circular cylinder. This is commonly called the Coandă-effect, and here we deploy it periodically on a spring-stabilized vertical cylinder, to produce reciprocating motion. This Co andă-based Re ciprocating ( CoRe ) system converts wind energy to mechanical work. Compared to wind turbines and windmills, the CoRe system generates higher torque and is therefore well suited to directly driving positive displacement pumps for drip-irrigation or reverse osmosis water desalination. This new approach necessitates the investment of energy in order to extract energy from the wind and therefore a major challenge is to maximize the output/input ratio in order to render the concept viable. Previous preliminary wind tunnel tests conducted on the CoRe system produced gross and net power coefficients of 10% and 3% respectively. However, the blowing slot design has a decisive impact on output power. On the basis of data presented in the literature and our computational analysis, the CoRe system produces significantly greater torque than all types of wind turbines with net power coefficients over 10%.
TSA, an SDN architecture including end terminals (2016)

In this work we integrate user terminals into an SDN architecture that allows global network optimization. We embed an SDN virtual switch into a mobile user terminal in such a way that a centralized controller, using both terminal and network-side information, can decide which access network terminal should connect to. User profiling and terminal interface configuration are integral parts of the architecture.
Photon Counting Histogram for One‐Photon Excitation (2003)

where VG = ω02z0 is the observation volume in an FCS treatment using the three-dimensional Gaussian observation volume profile (see Equation (3) in the article). This correct form was used in all calculations. The authors apologize for any misunderstandings that may arise as a result of this error.
Installing the Anasazi Eigensolver Package with Application to Some Graph Eigenvalue Problems (2014)

The purpose of this report is to document a basic installation of the Anasazi eigensolver package and provide a brief discussion on the numerical solution of some graph eigenvalue problems.
Synthesis of acyclic nucleoside 5-o-carboranyl uracil derivative (2007)

The synthesis of 1-(2,2-dihydroxymethyl-3-hydroxypropoxymethyl)-5-o-carboranyl uracil 7 as potentially antiviral agent and a suitable candidate for BNCT is described starting from 5,5- dihydroxymethyl-1,3-dioxane 1, an intermediate 2,2,2-triacetoxymethyl ethoxymethyl acetyl 2 was synthesized and coupled with 5-Iodouracil to get 1-(2,2,2- riacetoxymethyl ethoxymethyl)-5-iodouracil 3 which enabled us to obtain the final compound 7. La synthese du 1-(2,2-dihydroxymethyl-3-hydroxypropoxymethyl)-5-o-carboranyl uracile 7, un nucleoside acyclique pouvant etre  potentiellement antiviral et candidat la boron neutron capture therapy (BNCT) est ici decrite. Partant du 5,5-dihydroxymethyl-1,3-dioxane 1, l’intermediaire 2,2,2- triacetoxymethyl ethoxymethyl acetyle 2 est obtenu, puis il est couple avec le 5-Iodouracile pour isolement du compose cle le 1-(2,2,2-triacetoxymethyl ethoxymethyl)-5-iodouracile 3 permettant la synthese du produit final 7.
A Host–Guest Relationship in Bone Morphogenetic Protein Receptor-II Defines Specificity in Ligand–Receptor Recognition (2012)

One of the most intriguing questions confronting the bone morphogenetic protein family is the mechanism of ligand recognition, because there are more ligands than receptors. Crystal structures of two type II receptors, ActR-II and BMPR-II, are essentially identical, and a loop structure (A-loop) has been suggested to play a role in determining ligand specificity. A solution biophysical study showed mutations of several A-loop residues in these two receptors exert different ligand binding effects. Thus, the issues of mechanism of ligand recognition and specificity remain unresolved. We examined effects of mutations of residues Y40, G47, and S107 in BMPR-II. These residues are not identified as being in contact with the ligand in the BMP-7-BMPR-II complex but are found mutated in genetic diseases. They are likely to be useful in identifying their roles in differentiating the various BMP ligands. Spectroscopic probing revealed little mutation-induced structural change in BMPR-II. Ligand binding studies revealed that Y40 plays a significant role in differentiating three distinct ligands; G47 and S107 affect ligand binding to a lesser extent. The role of the A-loop in ActR-II or BMPR-II is dependent on the host sequence of the receptor extracellular domain (ECD) in which it is embedded, suggesting a host-guest relationship between the A-loop and the rest of the ECD. Computational analysis demonstrated a long-range connectivity between Y40, G47, and S107 and other locations in BMPR-II. An integration of these results on functional energetics and protein structures clearly demonstrates, for the first time, an intradomain communication network within BMPR-II.
Minimizing false positives in kinase virtual screens (2006)

In spite of recent improvements in docking and scoring methods, high false-positive rates remain a common issue in structure-based virtual screening. In this study, the distinctive features of false positives in kinase virtual screens were investigated. A series of retrospective virtual screens on kinase targets was performed on specifically designed test sets, each combining true ligands and experimentally confirmed inactive compounds. A systematic analysis of the docking poses generated for the top-ranking compounds highlighted key aspects differentiating true hits from false positives. The most recurring feature in the poses of false positives was the absence of certain key interactions known to be required for kinase binding. A systematic analysis of 444 crystal structures of ligand-bound kinases showed that at least two hydrogen bonds between the ligand and the backbone protein atoms in the kinase hinge region are present in 90% of the complexes, with very little variability across targets. Closer inspection showed that when the two hydrogen bonds are present, one of three preferred hinge-binding motifs is involved in 96.5% of the cases. Less than 10% of the false positives satisfied these two criteria in the minimized docking poses generated by our standard protocol. Ligand conformational artifacts were also shown to contribute to the occurrence of false positives in a number of cases. Application of this knowledge in the form of docking constraints and post-processing filters provided consistent improvements in virtual screening performance on all systems. The false-positive rates were significantly reduced and the enrichment factors increased by an average of twofold. On the basis of these results, a generalized two-step protocol for virtual screening on kinase targets is suggested.
The Improved Particle Filter Algorithm Based on Weight Optimization (2013)

Particle filter algorithm is to achieve recursive Bayesian filter through the simulation method of non-parameter Monte Carlo, It based on sequential importance sampling, and can not avoid particle degeneration problem, a way to overcome the particle degradation is re-sampling, However sample impoverishment will appear in the process of re-sampling, This paper proposes an improved particle filter method based on optimized weight. To some extent, the method solves the particle impoverishment problem, According to simulation results, we can confirm that the improved particle filter algorithm proposed in the paper can effectively improve the estimation precision of particle filter algorithm.
Isolated flushes without permanent, fixed or other skin lesions in patients with systemic mastocytosis: a case series of 9 patients (2015)

Mastocytosis is a heterogeneous group of disorders characterized by abnormal growth and accumulation of mast cells (MCs) in one or more organ systems [1, 2]. Clinical manifestations of mastocytosis are related to the release of MC mediators or to pathological MC infiltration [1, 2]. Urticaria pigmentosa is present in almost 60% of cases of systemic mastocytosis [2-5].Flushing is a sensation of warmth accompanied by transient erythema, usually over the face, neck, ears, chest and limbs and is due [...]