gebhart/patrepeval huggingface dataset:
Observational Quantitative Data in Adult Patients with SMA Dosed with Nusinersen (P4.4-007) (2019)

In this report, our large adult center of approaching 40 patients dosed with nusinersen seeks to share our experience as well as to present lab, strength and functional objective measurements collected from our adult SMA populations dosed with nusinersen since 6/2017.
Elucidating synergistic dependencies in lung adenocarcinoma by proteome-wide signaling-network analysis (2019)

To understand drug combination effect, it is necessary to decipher the interactions between drug targets-many of which are signaling molecules. Previously, such signaling pathway models are largely based on the compilation of literature data from heterogeneous cellular contexts. Indeed, de novo reconstruction of signaling interactions from large-scale molecular profiling is still lagging, compared to similar efforts in transcriptional and protein-protein interaction networks. To address this challenge, we introduce a novel algorithm for the systematic inference of protein kinase pathways, and applied it to published mass spectrometry-based phosphotyrosine profile data from 250 lung adenocarcinoma (LUAD) samples. The resulting network includes 43 TKs and 415 inferred, LUAD-specific substrates, which were validated at >60% accuracy by SILAC assays, including "novel' substrates of the EGFR and c-MET TKs, which play a critical oncogenic role in lung cancer. This systematic, data-driven model supported drug response prediction on an individual sample basis, including accurate prediction and validation of synergistic EGFR and c-MET inhibitor activity in cells lacking mutations in either gene, thus contributing to current precision oncology efforts.
Diagnostic Platform For Rapid Identification and Virulence Characterization of Infectious Pathogens Based on Host Response. (2011)

Abstract not provided.
Study on Precision Machine Table Equipped with Constant-Flow Hydrostatic Water Bearings (2009)

In order to realize environmental-friendly machine tools, a linear-motor-driven table supported by constant-flow hydrostatic water bearings is developed. The table system is free from environmental pollution because the system needs no oil. For simplicity, a single-sided bearing system is chosen for the table-slide. To obtain a high sustaining force, preload is applied to the bearings using the attractive force of an iron core linear-motor’s magnets. The preload is effective in both the vertical and horizontal directions by inclined motor magnets. Miniature gear-pumps supply flow to the bearings without pump pulsation, and the bearings consume very small amounts of water and electric power. The measured table sustaining force was 3.0kN and static stiffness was 0.3kN/m under a flow rate Q=0.92mL/s per bearing and ideal bearing clearance h=16m.
SNARKs to the rescue: proof-of-contact in zero knowledge (2020)

This paper describes techniques to help with COVID-19 automated contact tracing, and with the restoration efforts. We describe a decentralized protocol for ``proof-of-contact'' in zero knowledge where a person can publish a short cryptographic proof attesting to the fact that they have been infected and that they have come in contact with a set of people without revealing any information about any of the people involved. More importantly, we describe how to compose these proofs to support broader functionality such as proofs of $n$th-order exposure which can further speed up automated contact tracing. The cryptographic proofs are publicly verifiable, and places the burden on the person proving contact and not on third parties or healthcare providers rendering the system more decentralized, and accordingly more scalable.
Efficient Method for the Preparation of Inverted Alkyl Carboxylates and Phenyl Carboxylates via Oxidation—Reduction Condensation Using 2,6‐Dimethyl‐1,4‐benzoquinone or Simple 1,4‐Benzoquinone. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Novel and Potent NPY5 Receptor Antagonists Derived from Virtual Screening and Iterative Parallel Chemistry Design. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Development of Screening Method of Dioxins in Environmental Samples by Enzyme-Linked Immunosorbent Assay (2006)

The purpose of this research is the establishment of ELISA for measuring dioxins in environmental samples, such as house dust, soil, exhaust gas and fly ash. Since we have developed dry-type plates in order to put the ELISA system into practical use, the basic performance, such as the cross-reactivity, linearity and the correlation between the conventional GC/MS values and the ELISA values, were studied. The dry plates could be stored for about one year in a refrigerator. Furthermore, a good correlation was observed between the dioxin quantities by ELISA and those by GC/MS in exhaust gas, fly ash, soil and house dust samples. The developed ELISA system indicated usefulness as a toxicity evaluation method for dioxins in environmental samples.
Robot audition: Its rise and perspectives (2015)

The ability of robots to listen to several things at once with their own “ears”, that is, robot audition, is an important factor in improving interaction and symbiosis between humans and robots. The critical issue in robot audition is real-time processing and robustness against noisy environments with high flexibility to support various kinds of robots and hardware configurations. This paper first overviews activities and issues related to robot audition. Then, it presents the “HARK” robot audition software, which provides three primary functions for robot audition, sound source localization, sound source separation, and separated sound recognition, and then reports their performance. Finally, it discusses future directions in new promising areas as well as robotics.
Spectral Self-Compression in Gas-Filled Hollow-Core Photonic Crystal Fiber (2022)

We demonstrate spectral self-compression in a hollow-core gas-filled photonic crystal fiber for the generation of high energy ps pulses with limited bandwidths.
Percutaneous endoscopic jejunostomy in a patient with previous esophagectomy. (1991)

Establishment of a percutaneous endoscopic jejunostomy via direct jejunal puncture was accomplished in a 45-year-old woman five years after a partial esophagectomy with cervical esophagogastrostomy for adenocarcinoma of the esophagus. The patient had recurrence of the cancer at the anastomotic site with subsequent inability to eat, necessitating a feeding tube for prolonged enteral nutrition. Although percutaneous puncture of the jejunum has been previously described, it has been limited to patients who had undergone partial or complete gastrectomies with Bilroth II anastomoses. This case report of direct endoscopic jejunal tube placement in a patient after esophagectomy further establishes this procedure as a viable alternative to surgically placed feeding tubes in patients with altered gastric anatomy.
In vivo Small Animal Imaging using Combined MR-DOT System (2006)

We developed a simultaneous MR-DOT system for small animal imag-ing. MRI image is used as a priori information for DOT reconstruction providing accurate geometry and boundary condition. System performance is demonstrated in vivo with ENU tumor bearing rat.
Measurement of the ultrafast dynamics of nonlinear refraction and absorption of highly doped semiconductors at epsilon-near-zero (Conference Presentation) (2018)

Materials exhibiting near zero refractive index are shown to have interesting nonlinear optical properties such as enhanced second and third harmonic generation, and large nonlinear refraction (NLR) due to their unique interplay between linear and nonlinear optical features. In particular, the NLR of highly doped semiconductors such as Indium Tin Oxide and Aluminum doped Zinc Oxide is enhanced in the near-infrared spectral regions, where the real part of the permittivity crosses zero with the advantage of having a tunable zero crossover frequency by controlling the doping level. This is also known as the epsilon near zero (ENZ) regime, where the refractive index is very small. We have used the Beam-Deflection (BD) method to directly characterize the temporal dynamics and polarization dependence of the nondegenerate (ND) NLR of doped semiconductors at ENZ. The origin of the nonlinear optical response of these materials is different than for the case of bound electronic nonlinearities which depend upon the third-order susceptibility. The ND BD technique has the potential to study the dependence on relative polarization of excitation and probe waves to accurately determine the instantaneous electronic nonlinearities separately from the non-instantaneous mechanisms such as carrier redistribution effects, however, the carrier nonlinearities are dominant in such materials. This method also reveals the effect of tuning the wavelength of excitation or probe waves through ENZ separately. BD has sensitivity to induced optical path length as small as 1/20,000 of a wavelength, which enables the possibility to resolve NLR in the presence of large nonlinear absorption backgrounds.
Primary structure of streptococcal Pep M5 protein: Absence of extensive sequence repeats (1983)

Extensive sequence repeats have been observed in a biologically active fragment of type 24 streptococcal M protein, namely Pep M24 [Beachey, E. H., Sayer, J. M. & Kang, A. H. (1978) Proc. Natl. Acad. Sci. USA 75, 3163-3167]. To determine whether such extensive repetition in sequence is a common characteristic of the antiphagocytic streptococcal M proteins, we have determined the sequences of the clostripain peptides of Pep M5, a biologically active fragment of the type 5 M protein that is analogous to Pep M24. These sequences, together with the amino-terminal sequence of the whole molecule, accounted for nearly two thirds of the Pep M5 molecule. However, extensive identical repeats of the kind observed in Pep M24 were not present in Pep M5. Preliminary study of the amino acid sequence analysis of the M protein from type 6 Streptococcus has also indicated the absence of sequence repeats within the regions of this molecule examined so far. These results suggest that extensive sequence repeats may not be a common characteristic of M-protein molecules. On the other hand, the seven-residue periodicity of the nonpolar residues, a characteristic of alpha-helical coiled-coil structures, appeared to extend over most of the Pep M5 molecule. This feature has been observed previously for the partial sequences of three M protein serotypes. Thus, the important element of the M-protein structure appears to be the seven-residue periodicity necessary for the maintenance of the coiled-coil structure rather than extensive identical amino acid sequence repeats.
Thermal activation and saturation of ion beam sculpting (2011)

We report a material-dependent critical temperature for ion beam sculpting of nanopores in amorphous materials under keV ion irradiation. At temperatures below the critical temperature, irradiated pores open at a rate that soon saturates with decreasing temperature. At temperatures above the critical temperature, the pore closing rate rises rapidly and eventually saturates with increasing temperature. The observed behavior is well described by a model based on adatom diffusion, but is difficult to reconcile with an ion-stimulated viscous flow model.
AI Theory and Practice: A Discussion on Hard Challenges and Opportunities Ahead (2010)

A special track on directions in artificial intelligence at a Microsoft Research Faculty Summit included a panel discussion on key challenges and opportunities ahead in AI theory and practice. This article captures the conversation among eight leading researchers.
Development of (E)-2-((1,4-Dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-Amidinophenylbenzamides as Potent Inhibitors of Venezuelan Equine Encephalitis Virus (2014)

Venezuelan equine encephalitis virus (VEEV) is an emerging pathogenic alphavirus that can cause significant disease in humans. Given the absence of therapeutic options available and the significance of VEEV as a weaponized agent, an optimization effort was initiated around a quinazolinone screening hit 1 with promising cellular antiviral activity (EC50 = 0.8 μM), limited cytotoxic liability (CC50 > 50 μM), and modest in vitro efficacy in reducing viral progeny (63-fold at 5 μM). Scaffold optimization revealed a novel rearrangement affording amidines, specifically compound 45, which was found to potently inhibit several VEEV strains in the low nanomolar range without cytotoxicity (EC50 = 0.02-0.04 μM, CC50 > 50 μM) while limiting in vitro viral replication (EC90 = 0.17 μM). Brain exposure was observed in mice with 45. Significant protection was observed in VEEV-infected mice at 5 mg kg(-1) day(-1) and viral replication appeared to be inhibited through interference of viral nonstructural proteins.
The Interchangeable Module Stellarator (1981)

The Interchangeable Module Stellarator (IMS) is a new toroidal stellarator-type device under design and construction at the University of Wisconsin Torsatron/Stellarator Laboratory. A new design strategy for constructing stellarator magnetic fields from discrete modular coils has been developed, utilizing orthogonal toroidal coordinates. Application of this method has resulted in a modular coil system (IMS), whose magnetic structure closely approximates that of the Proto-Cleo Q = 3 7-field period device (i. e., rotational transform, shear, flux volume, etc.).
Organocatalytic Ring-Opening Polymerization of Morpholinones: New Strategies to Functionalized Polyesters (2014)

The oxidative lactonization of N-substituted diethanolamines with the Pd catalyst [LPd(OAc)]2(2+)[OTf(-)]2 generates N-substituted morpholin-2-ones. The organocatalytic ring-opening polymerization of N-acyl morpholin-2-ones occurs readily to generate functionalized poly(aminoesters) with N-acylated amines in the polyester backbone. The thermodynamics of the ring-opening polymerization depends sensitively on the hybridization of the nitrogen of the heterocyclic lactone. N-Acyl morpholin-2-ones polymerize readily to generate polymorpholinones, but the N-aryl or N-alkyl substituted morpholin-2-ones do not polymerize. Experimental and theoretical studies reveal that the thermodynamics of ring opening correlates to the degree of pyramidalization of the endocyclic N-atom. Deprotection of the poly(N-Boc-morpholin-2-one) yields a water-soluble, cationic polymorpholinone.
Corrections to “Learning-Based Signal Detection for Wireless OAM-MIMO Systems With Uniform Circular Array Antennas” (2021)

In the above article <xref ref-type="bibr" rid="ref1" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">[1]</xref> , the following corrections should be made:
Optimal dose of succinylcholine for laryngeal mask airway insertion: systematic review, meta-analysis and metaregression of randomised control trials (2017)

The use of succinylcholine compared with none can facilitate LMA insertion and reduce insertion-related reflexes without significant postoperative myalgia. However, additional prospective studies with a larger sample size are required to fully evaluate the dose-dependent effect and complications of succinylcholine for LMA insertion.
<title>Miniature silicon electronic biological assay chip and applications for rapid battlefield diagnostics</title> (1999)

Assessing the medical condition of battlefield personnel requires the development of rapid, portable biological diagnostic assays for a wide variety of antigens and enzymes. Ideally, such an assay would be inexpensive, small, and require no added reagents while maintaining the sensitivity and accuracy of laboratory-based assays. In this work, a microelectromechanical (MEMS) based biological assay sensor is presented which is expected to meet the above requirements. The sensor is a thin silicon membrane resonator (SMR) which registers a decrease in resonant frequency when mass is adsorbed onto its surface. By coating the sensor surface with a monolayer of antibody, for example, we have detected the corresponding antigen with a detection resolution of 0.25 ng/ml in phosphate buffer solution. Micromachining techniques are being used to integrate many (64 elements on the first test chip) identical SMR sensors into a single silicon chip which would be capable of simultaneously performing a wide variety of biomedical assays. The sensors require only a small printed circuit board and 8V power supply to operate and provide a readout. The presentation will describe the operation of the SMR sensor, the fabrication of the sensor array, and initial test results using commercially available animal immunoglobulins in laboratory-prepared test solutions.
3P1-S04 Development of Robot Finger using Ultrasonic Motors driven by Superimposed Signal Input(Robot Hand Mechanism and Grasping Strategy (1)) (2014)

When developing a multi-fingered robot hand driven by ultrasonic motors (USM), complicated wiring may become one of the essential problems. This study introduces a novel driving method of multiple USMs using superimposed signal input to overcome this problem. First, we designed a robot finger driven by built-in USMs. The robot finger has four joints with three-degree-of-freedom, i.e., DIP joint is dependent to PIP joint. Second, we developed the USMs which may actuate the robot finger. Finally, we developed and characterized the robot finger with the superimposed signal input.
On Using 'Symbiotic Relationship' to Repel Network Flooding Attack (2009)

This memo describes a simple defense mechanism against a specific type
of network flooding attacks. The suggested mechanism requires a mobile
node to establish a 'symbiotic relationship' with the
infrastructure, in order to empower it to repel such attack while
giving enough insurance to the source(s) of the traffic about the need
to cease sending traffic to the targeted network.
Oxidation of methyl linoleate in micellar solutions induced by the combination of iron(II)/ascorbic acid and iron(II)/H2O2 (2005)

The oxidation of methyl linoleate (ML) was studied in the presence of Fe(II) alone and its combination with either ascorbic acid (AsAH2) or hydrogen peroxide (H2O2) at diVerent molar ratios. Reactions were carried out in micellar solutions of TTAB (tetradecyltrimethylammonium bromide) and SDS (sodium dodecyl sulfate), respectively, and were monitored by UV spectroscopy and electrospray ionization mass spectrometry (ESI-MS). Fe(II) alone was able to catalyze the oxidation of ML in micellar solutions of TTAB, but not in those of SDS. The combination of H2O2 with Fe(II) showed catalytic eVect only in the TTAB medium, leading to diVerent ML and Fe(II) oxidation kinetics compared to the Fe(II)-only catalyzed reactions. The AsAH2/Fe(II) combination demonstrated to be a good catalyst for the oxidation of ML in SDS micellar solutions, but not in TTAB micellar solutions; the activity of the catalyst was dependent on the AsAH2/Fe(II) molar ratio. The obtained results conWrm that, for the ML oxidation to be initiated, the presence of a Fe(II)/Fe(III) couple is essential, which is related to the pH of micellar solutions. The catalytic properties of the AsAH2/Fe(II) combination were explained by taking into account the anti-oxidant and pro-oxidant properties of AsAH2, as well as the possible formation of an iron/ascorbate complex as the initiator of the ML oxidation.
Selective Rb+ vs. K+ Guest Incorporation in Wheel‐Shaped 27‐Tungsto‐3‐Arsenate(III) Host, [M⊂{(β‐AsIIIW8O30)(WO(H2O))}3]14– (M = K, Rb) (2018)

The wheel‐shaped, potassium‐templated 27‐tungsto‐3‐arsenate(III) [K⊂{(β‐As III W 8 O 30 )(WO(H 2 O))} 3 ] 14– ( 1 ) was synthesized by simple one‐pot condensation of the trilacunary [ B ‐α‐As III W 9 O 33 ] 9– precursor in aqueous, acidic KCl solution. Polyanion 1 comprises three β‐{AsW 8 O 30 } units linked via three trans ‐{WO(H 2 O)} groups, forming a cyclic assembly with a potassium ion located in the central cavity. The rubidium‐analogue [Rb⊂{(β‐As III W 8 O 30 )(WO(H 2 O))} 3 ] 14– ( 2 ) could also be prepared, by addition of a small amount of Rb + ions to a solution containing a large excess of K + ions. This indicates that the rigid [{(β‐As III W 8 O 30 )(WO(H 2 O))} 3 ] 15– (As 3 W 27 ) host exhibits high selectivity for Rb + ion guests compared to K + ions. Polyanions 1 and 2 were characterized in the solid state by single‐crystal XRD, FT‐IR, TGA, and elemental analysis.
Enhanced luminescence and two‐photon absorption of silver nano‐clusters (2009)

Abstract Luminescence of silver nanoparticles photo‐deposited on titan dioxide nanoparticles of mesoporous film is studied. Luminescence was registered under the two‐photon excitation by femto‐second laser pulses of Ti:sapphire laser. It was observed that Ag/ TiO 2 mesoporous films have high concentration of bright luminescence spots which reveal stability to degradation under long illumination. Various configurations of silver nanoparticles are analyzed to explain the physics of bright luminescence spots (“hot spots”). Luminescence intensity reveals “hot spots” dependence on the polarization of excitation laser pulse. Properties of Ag/TiO 2 system can be useful for single molecule spectroscopy and visualization of biological objects. Aapplication of Ag/ TiO 2 mesoporous films for Raman scattering spectroscopy de‐menstruated for the case of Rhodamine B. (© 2009 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
A Human-Robot Interface based on Surface Electroencephalographic Sensors (2020)

We propose a human-robot interface based on potentials recorded through surface Electroencephalographic sensors, aiming to decode human visual attention into motion in three-dimensional space. Low-frequency components are extracted and processed in real time, and subspace system identification methods are used to derive the optimal, in mean squared sense, linear dynamics generating the position vectors. This results in a human-robot interface that can be used directly in robot teleoperation or as part of a shared-control robotic manipulation scheme, feels natural to the user, and is appropriate for upper extremity amputees, since it requires no limb movement. We validate our methodology by teleoperating a redundant, anthropomorphic robotic arm in real time. The system's performance outruns similar EMG-based systems, and shows low long-term model drift, indicating no need for frequent model re-training.
The shift in sensory eye dominance from short-term monocular deprivation exhibits no dependence on test spatial frequency (2022)

The sensory eye dominance plasticity induced by short-term deprivation is not dependent on test spatial frequency, suggesting it could provide a practical solution for amblyopic therapy that was concerned with the binocular outcome.
Miniaturized 3D Imaging and Sensing Modules (2016)

3D imaging and sensing modules for smart and IoT devices pose demanding requirements on form factor, robustness and performance. Enabling technologies include wafer-level packaging, micro-optic, time-of-flight sensors, software and connectivity solutions.