gebhart/patrepeval huggingface dataset:
TGF-β Signaling Initiated in Dendritic Cells Instructs Suppressive Effects on Th17 Differentiation at the Site of Neuroinflammation (2014)

While the role of Transforming Growth Factor β (TGF-β) as an intrinsic pathway has been well established in driving de novo differentiation of Th17 cells, no study has directly assessed the capacity of TGF-β signaling initiated within dendritic cells (DCs) to regulate Th17 differentiation. The central finding of this study is the demonstration that Th17 cell fate during autoimmune inflammation is shaped by TGF-β extrinsic pathway via DCs. First, we provide evidence that TGF-β limits at the site of inflammation the differentiation of highly mature DCs as a means of restricting Th17 cell differentiation and controlling autoimmunity. Second, we demonstrate that TGF-β controls DC differentiation in the inflammatory site but not in the priming site. Third, we show that TGF-β controls DC numbers at a precursor level but not at a mature stage. While it is undisputable that TGF-β intrinsic pathway drives Th17 differentiation, our data provide the first evidence that TGF-β can restrict Th17 differentiation via DC suppression but such a control occurs in the site of inflammation, not at the site of priming. Such a demarcation of the role of TGF-β in DC lineage is unprecedented and holds serious implications vis-à-vis future DC-based therapeutic targets.
Virtual de-embedding study for the accurate extraction of Fin FET gate resistance (2014)

Accurate measurement of FET gate resistance is needed to support technology development and to understand its impact on RF performance. This is especially true for high-K Metal Gate Fin FET technologies. Decreasing gate capacitance with each successive technology node has made gate resistance measurement increasingly difficult. This work presents a "Virtual De-Embedding" approach to the optimization of gate resistance measurement structures and de-embedding methodologies. This optimization was done without needing to fabricate multiple test structure variations to determine the optimal structure. We examine the effects of back-end-of-line (BEOL) stack, groundplane design, FET size, and de-embedding technique on gate resistance measurement accuracy.
Implantation of Radiotelemetry Transmitters Yielding Data on ECG, Heart Rate, Core Body Temperature and Activity in Free-moving Laboratory Mice (2011)

The laboratory mouse is the animal species of choice for most biomedical research, in both the academic sphere and the pharmaceutical industry. Mice are a manageable size and relatively easy to house. These factors, together with the availability of a wealth of spontaneous and experimentally induced mutants, make laboratory mice ideally suited to a wide variety of research areas. In cardiovascular, pharmacological and toxicological research, accurate measurement of parameters relating to the circulatory system of laboratory animals is often required. Determination of heart rate, heart rate variability, and duration of PQ and QT intervals are based on electrocardiogram (ECG) recordings. However, obtaining reliable ECG curves as well as physiological data such as core body temperature in mice can be difficult using conventional measurement techniques, which require connecting sensors and lead wires to a restrained, tethered, or even anaesthetized animal. Data obtained in this fashion must be interpreted with caution, as it is well known that restraining and anesthesia can have a major artifactual influence on physiological parameters. Radiotelemetry enables data to be collected from conscious and untethered animals. Measurements can be conducted even in freely moving animals, and without requiring the investigator to be in the proximity of the animal. Thus, known sources of artifacts are avoided, and accurate and reliable measurements are assured. This methodology also reduces interanimal variability, thus reducing the number of animals used, rendering this technology the most humane method of monitoring physiological parameters in laboratory animals. Constant advancements in data acquisition technology and implant miniaturization mean that it is now possible to record physiological parameters and locomotor activity continuously and in realtime over longer periods such as hours, days or even weeks. Here, we describe a surgical technique for implantation of a commercially available telemetry transmitter used for continuous measurements of core body temperature, locomotor activity and biopotential (i.e. onelead ECG), from which heart rate, heart rate variability, and PQ and QT intervals can be established in freeroaming, untethered mice. We also present pre-operative procedures and protocols for post-operative intensive care and pain treatment that improve recovery, well-being and survival rates in implanted mice.
Reduced Hardware NOrec (2015)

Because of hardware TM limitations, software fallbacks are the only way to make TM algorithms guarantee progress. Nevertheless, all known software fallbacks to date, from simple locks to sophisticated versions of the NOrec Hybrid TM algorithm, have either limited scalability or weakened semantics. We propose a novel reduced-hardware (RH) version of the NOrec HyTM algorithm. Instead of an all-software slow path, in our RH NOrec the slow-path is a "mix" of hardware and software: one short hardware transaction executes a maximal amount of initial reads in the hardware, and the second executes all of the writes. This novel combination of the RH approach and the NOrec algorithm delivers the first Hybrid TM that scales while fully preserving the hardware's original semantics of opacity and privatization. Our GCC implementation of RH NOrec is promising in that it shows improved performance relative to all prior methods, at the concurrency levels we could test today.
Evaluating Efficiency of Multi-Layer Switching in Future Optical Transport Networks (2013)

This paper evaluates multi-layer switching architecture vs. all-optical and all-digital switching architectures. Further, the value of incorporating super-channels is evaluated to determine benefit. A real world network model is utilized to quantify and compare results.
Effet De LaS-Adenosyl-L-Homocysteine Sur Le Catabolisme De La Dopamine (1979)

1.--The administration of SAH to rats, at physiologically active dose on the sleep, does not change the urinary level of MD and NM. On the other hand, the excretion of DA and NA decreases. 2.--In the brain, SAH does not modify neither the concentration of NA and NM in hypothalamus and thalamus, nor the concentration of DA and MD in corpus striatum. 3.--After intracisternally injection of [14C]DA or [3H]NA, SAH increases the level of [14C]MD and [3H]NM. 4.--Contrary to the studies in vitro, where SAH is an inhibitor of COMT, on the rat it does not seem prevent the methylation of DA and NA.
Science Translational Medicine Podcast: 2 February 2011 (2011)

A conversation with Shannon Dahl about how to bioengineer off-the-shelf vascular grafts for use in surgical transplantation.
Laparoscopic Adrenalectomy for Solitary Metachronous Contralateral Adrenal Metastasis from Renal Cell Carcinoma (1997)

Laparoscopic adrenalectomy for metastatic renal cell cancer was performed successfully in 2 patients. However, the short-term benefits to the patient of earlier ambulation, decreased pain, minimal incisions and shortened convalescence must be weighted against the as yet unknown long-term (5 years) results.
Supporting Multi-messenger Astrophysics with Fast Gamma-ray Burst Localization (2021)

Multi-messenger astrophysics is amongst the most promising approaches to astronomical observations. A significant challenge, however, is the fact that many instruments have a narrow field of view, so transient events are often missed by these instruments. The Advanced Particle-astrophysics Telescope, currently under development, promises to provide low-latency detection and localization for an important class of astronomical events, thereby enabling the full observational capabilities of narrow field-of-view instruments to be brought to bear. We examine the computational pipeline for detection and localization of Compton events utilizing computational accelerators, both FPGAs and GPUs.
High Speed Imaging Using Multiple RF Coils for FASE Non-Contrast-Enhanced Blood Flow Imaging (in Japanese) (2000)

International audience
Orientational Order of Molecular Assemblies on Inorganic Crystals (2006)

Surfactant micelles form oriented arrays on crystalline substrates although registration is unexpected since the template unit cell is small compared to the size of a rodlike micelle. Interaction energy calculations based on molecular simulations reveal that orientational energy differences on a molecular scale are too small to explain matters. With atomic force microscopy, we show that orientational ordering is a dynamic, multimolecule process. Treating the cooperative processes as a balance between van der Waals torque on a large, rodlike micellar assembly and Brownian motion shows that orientation is favored.
Erratum: Efficient orbital angular momentum transfer between plasmons and free electrons [Phys. Rev. B 98, 045424 (2018)] (2019)

The explicit factor of should be removed from Eqs. (
Tandem repeat of C/EBP binding sites mediates PPAR?2 gene transcription in glucocorticoid-induced adipocyte differentiation (2000)

Bone marrow stromal stem cells differentiate into many different types of cells including osteoblasts and adipocytes. Long-term glucocorticoid treatment decreases osteoblastic activity but increases adipocytes. We investigated the mechanism of glucocorticoid-induced PPARgamma2 transcription. Treatment of human bone marrow stromal cells with dexamethasone induced the differentiation of these cells into adipocytes as measured by oil-red O staining, and Northern blot analysis showed that dexamethasone strongly induced PPARgamma2 mRNA expression in cells cultured in adipocyte induction medium. Moreover, the mRNA of C/EBPdelta, an adipocyte-promoting transcription factor, was also induced by dexamethasone in the presence of induction medium. Gel mobility shift assays using purified GST-C/EBPdelta fusion protein showed that C/EBPdelta specifically binds to a 40-base pair DNA element from PPARgamma2 promoter, which was found to contain a tandem repeat of C/EBP binding sites. Transfection studies in mouse mesenchymal C3H10T1/2 cells showed that it is the tandem repeat of the C/EBP binding site in PPARgamma2 promoter region that regulates dexamethasone-mediated PPARgamma2 gene activation. We conclude that glucocorticoid-induced adipogenesis from bone marrow stromal cells is mediated through a reaction cascade in which dexamethasone transcriptionally activates C/EBPdelta; C/EBPdelta then binds to PPARgamma2 promoter and transactivates PPARgamma2 gene expression. This activated master regulator, in turn, initiates the adipocyte differentiation.
Supplementary Figure 4 from Altered Runx1 Subnuclear Targeting Enhances Myeloid Cell Proliferation and Blocks Differentiation by Activating a miR-24/MKP-7/MAPK Network (2023)

Supplementary Figure 4 from Altered Runx1 Subnuclear Targeting Enhances Myeloid Cell Proliferation and Blocks Differentiation by Activating a miR-24/MKP-7/MAPK Network
Molybdenum Triamidoamine Systems. Reactions Involving Dihydrogen Relevant to Catalytic Reduction of Dinitrogen (2009)

[HIPTN(3)N]Mo(N(2)) (MoN(2)) ([HIPTN(3)N](3-) = [(HIPTNCH(2)CH(2))(3)N](3-) where HIPT = 3,5-(2,4,6-i-Pr(3)C(6)H(2))(2)C(6)H(3)) reacts with dihydrogen slowly (days) at 22 degrees C to yield [HIPTN(3)N]MoH(2) (MoH(2)), a compound whose properties are most consistent with it being a dihydrogen complex of Mo(III). The intermediate in the slow reaction between MoN(2) and H(2) is proposed to be [HIPTN(3)N]Mo (Mo). In contrast, MoN(2), MoNH(3), and MoH(2) are interconverted rapidly in the presence of H(2), N(2), and NH(3), and MoH(2) is the lowest energy of the three Mo compounds. Catalytic runs with MoH(2) as a catalyst suggest that it is competent for reduction of N(2) with protons and electrons under standard conditions. [HIPTN(3)N]MoH(2) reacts rapidly with HD to yield a mixture of [HIPTN(3)N]MoH(2), [HIPTN(3)N]MoD(2), and [HIPTN(3)N]MoHD, and rapidly catalyzes H/D exchange between H(2) and D(2). MoH(2) reacts readily with ethylene, PMe(3), and CO to yield monoadducts. Reduction of dinitrogen to ammonia in the presence of 32 equiv of added hydrogen (vs Mo) is not catalytic, consistent with dihydrogen being an inhibitor of dinitrogen reduction.
Symbol rate dependency of XPM-induced phase noise penalty on QPSK-based modulation formats (2008)

Systematic investigation of XPM impact on QPSK signals reveals that higher symbol rates are advantageous for reducing both intra-span generation and multi-span accumulation of phase noise.
Improvement on the current-voltage characteristics of polycrystalline silicon contacted n+-p junctions with high-field stressing (1990)

Improvement on the current-voltage characteristics of polycrystalline silicon contacted n+-p junctions after they were applied a high-field scanned stressing is reported. For the stressed diodes, the leakage current decreased as much as two orders, the breakdown voltage shifted from −45 to −60 V, and the forward ideality factor also decreased. Scanning electron microscopy photographs on the cross-sectional view of the junctions revealed that local melting might have occurred during stressing to cause the improvement.
Minimizing Induced Drag with Geometric and Aerodynamic Twist, CFD Validation (2005)

*† ‡ A more practical analytical solution for the effects of wing twist on the performance of a finite wing of arbitrary planform has recently been presented. This infinite series solution is based on Prandtl’s classical lifting-line theory and the Fourier coefficients are presented in a form that depends only on wing geometry. Except for the special case of an elliptic planform, this solution shows that, if properly chosen, wing twist can be used to reduce the induced drag for a wing producing finite lift. A relation for the optimum twist distribution on a wing of arbitrary planform was presented. If this optimum twist distribution is used, the new solution predicts that a wing of any planform can be designed for a given lift coefficient to produce induced drag at the same minimum level as an elliptic wing having the same aspect ratio and no twist. In the present paper, results predicted from this new lifting-line solution are compared with results predicted from CFD solutions. In all cases, the CFD solutions showed that the drag reduction achieved with optimum twist was equal to or greater than that predicted by lifting-line theory. Nomenclature An = coefficients in the infinite series solution to the lifting-line equation an = planform contribution to the coefficients in the infinite series solution to the lifting-line equation
Acquisition by the murine host of responsiveness toward various neoplastic cell lines, but not toward self, through adoptive transfer of a helper T-lymphocyte clone with antiself specificity. (1989)

Self-antigens, when expressed on neoplastic cells, have been shown to exhibit a certain antigenicity. We attempted to apply this antigenicity to enhance antitumor immune responses. Cells from the syngeneic, CD4+, CD8-, helper T-lymphocyte clone TE2 were adoptively transferred to C57BL/6 mice. TE2 lymphocytes recognize a self-antigen on splenocytes that is expressed aberrantly on the neoplastic cell lines EL4/8, EL4/13, B16-BL6, and PG19, all of C57BL/6 origin. Their adoptive transfer led to the rejection by the host of the former neoplastic cells and of 3LL carcinoma cells, administered 2 months later; inocula 40 to 80 times the minimal lethal size were rejected and conveyed to the mice a 10-fold enhanced cytotoxic T-lymphocyte response. Despite the autoimmune responsiveness of the TE2 T-lymphocytes, no graft-versus-host reaction was apparent. This conclusion is based on the absence of a polyclonal B-lymphocyte stimulation in the host, the stable number of residual donor TE2 cells, and the general health of the recipient mice. Consequently, the autoimmune and tumor-responsive TE2 cells, transplanted into the immune environment of the host, exhibit a specificity that is restricted toward neoplastic cells.
Accurate and Rapid Sequence Analysis of Adeno-Associated Virus Plasmids by Illumina Next-Generation Sequencing (2018)

Sequence validation of plasmid DNA is a crucial quality control step that must occur prior to adeno-associated virus (AAV) vector packaging through plasmid transfection. AAV cis-plasmids present unique challenges to sequence analysis, as they contain inverted terminal repeats and are prone to sequence rearrangements. An accurate and rapid next-generation sequencing approach has been established to analyze full-length sequences of AAV cis-plasmids within 3.5 days. Here, a step-by-step protocol is described that can reliably detect and identify the location and frequency of sequence variants commonly observed in AAV cis-plasmids.
Misreading of RNA Templates Containing 8-Oxo-7,8-Dihydroguanosine Or 8-Oxo-2′-O-Methylguanosine in cDNA Synthesis by Reverse Transcriptases (1999)

Abstract RNA template 30mers which contain 7,8-dihydroguanosine(8-oxoG) or 7,8-dihydro-2′-O-methylguanosine(8-oxo-G-Me) were chemically synthesized. 32P-Labeled DNA primer 19mer was extended with dNTPs by MMLV and AMV reverse transcriptases on the RNA templates. Incorporation of nucleotides opposite 8-oxoG and 8-oxoG-Me were investigated.
EPL - Equational Programming Language Parsing and Dimension Propagation (1988)

Abstract : This report gives a detailed description of parsing and dimensionality propagation for the Equational Programming Language compiler. The Equational Programming Language, called EPL, is a very high-level declarative language designed to specify parallel and real-time computations. The EPL compiler translates equational specifications into procedural, high level language (currently C). The compiler itself is written in C for UNIX based systems. Automated tools YACC and LEX has been used for lexical analysis and parsing. Detailed description is given of the design and implementation of the algorithms for building different structures (such as symbol table, equation trees, etc.). These structures are used by subsequent post-parsing analysis and code-generation phases of the EPL compiler. The description of the algorithm for dimensionality propagation is also included.
Objective functions for feature discrimination: theory (1989)

The contemporary dialogue between religion and psychiatry has its roots in what is called the clinical pastoral movement. The early leaders of the clinical pastoral movement (Anton Boisen, Elwood Worcester, Helen Flanders Dunbar, and Richard Cabot) were individuals of talent, even genius, whose lives and work intersected one another in the early decades of the twentieth century. Their legacy endures in the persons they inspired and continue to inspire and in the professional organizations and academic programs that profit from their pioneering work. To understand them and the era of their greatest productivity is to understand some of what psychiatry and religion have to say to each other. Appreciating their legacy requires attention to the context of historical movements and forces current in America at the end of the nineteenth and the beginning of the twentieth century that shaped religious, psychiatric, and cultural discourse. This essay attempts to provide an introduction to this rich and fascinating material. This material was first presented as a Grand Rounds lecture at The New York Presbyterian Hospital, Payne Whitney Westchester in the Department of Psychiatry, Weill Cornell Medical College.
Robust sound source mapping using three-layered selective audio rays for mobile robots (2016)

This paper investigates sound source mapping in a real environment using a mobile robot. Our approach is based on audio ray tracing which integrates occupancy grids and sound source localization using a laser range finder and a microphone array. Previous audio ray tracing approaches rely on all observed rays and grids. As such observation errors caused by sound reflection, sound occlusion, wall occlusion, sounds at misdetected grids, etc. can significantly degrade the ability to locate sound sources in a map. A three-layered selective audio ray tracing mechanism is proposed in this work. The first layer conducts frame-based unreliable ray rejection (sensory rejection) considering sound reflection and wall occlusion. The second layer introduces triangulation and audio tracing to detect falsely detected sound sources, rejecting audio rays associated to these misdetected sounds sources (short-term rejection). A third layer is tasked with rejecting rays using the whole history (long-term rejection) to disambiguate sound occlusion. Experimental results under various situations are presented, which proves the effectiveness of our method.
A 305mV-850mV 400μW 45GSamples/J reconfigurable compressive sensing engine with early-termination for ultra-low energy target detection in 14nm tri-gate CMOS (2016)

A reconfigurable compressive sensing engine for on-die acceleration of target threshold detection, feature extraction and depth perception is fabricated in 14nm Tri-Gate CMOS, and occupies 0.022mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Compressed-domain processing with sort-assisted thresholding, opportunistic early-termination using 3-stop checkpointing and in-line bound estimation enable 305mV-850mV operation with peak energy-efficiency of 45GSamples/J, measured at near-threshold operation of 340mV, resulting in 73× higher efficiency over conventional Nyquist-rate sensor digital front-ends.