gebhart/patrepeval huggingface dataset:
Data from Antibody-Based Profiling of the Phosphoinositide 3-Kinase Pathway in Clinical Prostate Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;i&gt;Purpose:&lt;/i&gt; As kinase inhibitors transition from the laboratory to patients, it is imperative to develop biomarkers that can be used in the clinic. The primary objectives are to identify patients most likely to benefit from molecularly targeted therapies and to document modulation of the drug target. Constitutive activation of the phosphoinositide 3-kinase (PI3K) pathway and its downstream effectors, as a result of PTEN loss or by other mechanisms, occurs in a high proportion of prostate cancers, making it an ideal template for the design of clinical trials involving PI3K pathway inhibitors. Prostate cancers also present unique organ-specific challenges, in that tumors are heterogeneous and diagnostic tissue is extremely limited.&lt;/p&gt;&lt;p&gt;&lt;i&gt;Experimental Design:&lt;/i&gt; Working within these limitations, we have developed a set of immunohistochemical assays that define activation of the PI3K pathway in clinical samples.&lt;/p&gt;&lt;p&gt;&lt;i&gt;Results&lt;/i&gt; and &lt;i&gt;Conclusions:&lt;/i&gt; Using both univariate and multivariate analyses, we show that loss of PTEN is highly correlated with the activation of AKT, and this, in turn, is associated with the phosphorylation of S6, one of its main effectors. These three antibodies are potentially able to define a molecular signature of PTEN loss and/or AKT pathway activation in prostate cancer.&lt;/p&gt;&lt;/div&gt;
VOVALEAD (2011)

Most news organizations provide immediate access to topical news broadcasts through RSS streams or podcasts. Until recently, applications have not permitted a user to perform content based search within a longer spoken broadcast to find the segment that might interest them. Recent progress in both automatic speech recognition (ASR) and natural language processing (NLP) has produced robust tools that allow us to now provide users with quicker and more focused access to relevant segments of news broadcast videos. Our public online demonstrator of the Voxalead application currently indexes daily broadcast news content from 50 sources in English, French, Chinese, Arabic, Spanish, Dutch, Italian and Russian.
Cross-talk between LOX-1 and PCSK9 in vascular tissues (2015)

These observations suggest that LOX-1 and PCSK9 positively influence each other's expression, especially during an inflammatory reaction. mtROS appear to be important initiators of PCSK9/LOX-1 expression.
Detecting Glaucoma Progression From Localized Rates of Retinal Changes in Parametric and Nonparametric Statistical Framework With Type I Error Control (2014)

The PixR provided higher sensitivity in progressing eyes and similar specificity in normals than SIM, suggesting that PixR strategies can improve our ability to detect glaucomatous progression. Longer follow-up is necessary to determine whether nonprogressing eyes identified as progressing by these methods will develop glaucomatous progression. (ClinicalTrials.gov number, NCT00221897).
9.3 A BJT-based temperature sensor with a packaging-robust inaccuracy of ±0.3°C (3σ) from −55°C to +125°C after heater-assisted voltage calibration (2017)

This paper presents a BJT-based temperature sensor, which can be accurately trimmed in both ceramic and plastic packages, on the basis of purely electrical measurements at room temperature. This is achieved by combining the voltage-calibration technique from [1] with an on-chip heater, which can heat the sensing BJTs from room temperature to ~85°C in 0.5s. Measurements show that the sensor can then be trimmed to an inaccuracy of ±0.3°C (3σ) over the military range (-55 to +125°C). This is similar to the inaccuracy obtained after conventional temperature calibration, i.e., at well-defined temperatures, but requires much less calibration time and infrastructure.
Composite Damping Ceramic Coatings by Polymer Impregnation (2006)

The interest in the use of thermal barrier ceramic coatings as damping treatments has recently arisen since they were shown to provide sufficient additional damping. Ceramic coatings can be applied mainly by either Air Plasma Spraying (APS) or Electron Beam - Physical Vapour Deposition (EBPVD). APS was used to deposit the specimens studied here. Previous research has shown that it is possible to enhance their damping effectiveness by tailoring the deposition parameters. This paper presents further work aimed at improving their damping effectiveness significantly by introducing a second material in the ceramic coating; thus creating a composite system. This paper covers the experimental findings of impregnating a ceramic damping coating with a number of commercially available polymeric materials. The most promising case of a type of Polyurethane provided over 40% improvement and was selected for further tests at various temperatures, ranging from -40 to 150 C. Furthermore, the damping and stiffness of ceramic coatings present amplitude-dependent behaviour which was also taken into consideration when evaluating the composite system. Finally, the paper concludes with a discussion of these promising findings as well as planned research into understanding the physical mechanisms dissipating energy in this composite material.
Overview on the Security in 5G Phase 2 (2020)

During the early development stages of the 5G specifications by 3GPP, it was quickly identified that it is not possible to address all the use cases of the 5G System within the normal Release timeframe. Therefore, it was decided to split the work in two phases. The 5G Phase 1 work focused on the foundation of the new system while 5G Phase 2 focused more on the needed enhancements to address the use cases. The work on the security in 5G Phase 1 was ample enough to deliver all the needed mechanisms not only to secure the communication between the different entities but also to protect the privacy of the user. Therefore, it is expected that the work on 5G Phase 2 will unlikely have impact on the security mechanisms. Nevertheless, some of the new features in 5G Phase 2 give rise to subtle security challenges which may require enhancements to the existing mechanisms. In this article, we consider some of the 5G Phase 2 features and shed light on such security aspects.
Regulation of epithelial Na+ channels from M-1 cortical collecting duct cells (1996)

The M-1 cell line is derived from the mouse cortical collecting duct and displays the low-conductance, highly Na(+)-selective channel activity of the alpha,beta, gamma-heterotrimeric epithelial Na+ channel (ENaC). The short-circuit current (Isc) across M-1 monolayers was 89 +/- 4 microA/cm2, and the transepithelial conductance was 2.1 +/- 0.2 mS/cm2. Isc was abolished by blocking the Na+ pump with ouabain. Both Isc and transepithelial conductance (gT) were inhibited by benzamil > amiloride >> dimethylamiloride. Under our experimental conditions, vasopressin, vasopressin, forskolin, and dibutyryl adenosine 3',5'-cyclic monophosphate (cAMP) had no detectable effects on Isc or gT. Increasing apical Na+ entry with nystatin increased Isc. The possible regulation of the M-1 Na+ channel by cAMP-activated protein kinase A (PKA) was further examined with excised inside-out patches. The open-time probability (Po) was not fixed, displaying substantial variance. Perfusion with ATP itself, with the catalytic subunit of PKA with ATP, or with alkaline phosphatase had no consistent effect on Po, the unitary current, or the kinetics of the M-1 Na+ channel. The data are consistent with the concept that PKA stimulates ENaCs by phosphorylating a site with access to but not within the apical membrane patch during cell-attached and excised-patch studies.
Contamination of Power Generation Lubricants (2007)

Abstract This paper examines the potential sources of fluid contamination that may occur during the manufacture, transportation, delivery, and use of a turbine oil for power generation. A turbine oil is a very precise formulation. If it becomes polluted with other lubricants or water, its performance could be compromised. The paper first identifies the potential sources of contamination that may be found when using a turbine oil. Then the consequences of contamination of the lubricant are considered. In conclusion, the paper proposes possible solutions to some of these practical problems regarding the sources of contamination. The paper will not consider the effects of particulate contamination. Because this is a well documented subject, the need for high levels of cleanliness in turbines is accepted practice.
[Saint Petersburg Institute of Bioregulation and Gerontology: achievements and prospects (towards the 20th anniversary)]. (2013)

The article presents the results of the 20-years' long activity of the Saint Petersburg Institute of Bioregulation and Gerontology founded to fulfill the basic and applied tasks in the sphere of gerontology and to integrate with medical practice new methods for preventing premature aging and age-related pathology by means of pharmaceuticals based on peptide bioregulators. Among the Institute main achievements are the scientific developments in the field of peptide regulation of aging, creation of a new medical domain--bioregulation therapy, and foundation of the Russian school of biogerontology. As a result of investigations, a key role of peptides in the regulation of aging process has been established, and a method of bioregulators complex application has been developed to increase organism resistance to various unfavorable factors and enhancement of human vital resource. At present 6 drugs and over 60 peptide bioregulators are widely used for prevention and treatment of many diseases. 9 new peptide preparations revealing geroprotective properties are submitted to the Russian Health Ministry to be registered as drugs.
Developing an Animal Model of Massive Ulcer Bleeding for Assessing Endoscopic Hemostatic Devices (2005)

This animal model provides reproducible massive hemorrhage suitable for endoscopic studies. Control of gastric bleeding from large arteries by endoscopic suturing is possible.
Investigation of tip current and normal force measured simultaneously during local oxidation of titanium using dual‐mode scanning probe microscopy (2014)

In this reported work, scanning probe microscopy is used to perform localised oxidation of Ti as a bottom‐up nanofabrication method. The effects of normal force setpoint and oxidation voltage on oxide nanofeatures during atomic force microscopy (AFM) mode and scanning tunnelling microscopy (STM) mode oxidation are investigated. The normal force between the probe and sample and electrochemical current in the anodic oxidation process are measured using a custom control system, and the effects of these variables on the size and resistivity of oxidised nanopatterns are investigated. It is shown that a direct relation exists between oxidation voltage and written oxide resistivity as well as written feature width in the STM mode oxidation. In AFM mode oxidation, the normal force setpoint is shown to have a positive correlation with feature size, but an inverse relation with oxide resistivity. By leveraging the presented system's ability to operate in both AFM and STM mode, the dynamics and feature fabrication dependencies are shown to be a continuum of writing voltage and normal force. This reported work suggests that STM and AFM mode oxidation can be thought of as similar processes but working at different operating points in terms of normal force and tip‐surface spacing.
Viral-Bacterial Interactions and Risk of Acute Otitis Media Complicating Upper Respiratory Tract Infection (2011)

Acute otitis media (AOM) is a common complication of upper respiratory tract infection whose pathogenesis involves both viruses and bacteria. We examined risks of acute otitis media associated with specific combinations of respiratory viruses and acute otitis media bacterial pathogens. Data were from a prospective study of children ages 6 to 36 months and included viral and bacterial culture and quantitative PCR for respiratory syncytial virus (RSV), human bocavirus, and human metapneumovirus. Repeated-measure logistic regression was used to assess the relationship between specific viruses, bacteria, and the risk of acute otitis media complicating upper respiratory tract infection. In unadjusted analyses of data from 194 children, adenovirus, bocavirus, Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis were significantly associated with AOM (P < 0.05 by χ(2) test). Children with high respiratory syncytial virus loads (≥3.16 × 10(7) copies/ml) experienced increased acute otitis media risk. Higher viral loads of bocavirus and metapneumovirus were not significantly associated with acute otitis media. In adjusted models controlling for the presence of key viruses, bacteria, and acute otitis media risk factors, acute otitis media risk was independently associated with high RSV viral load with Streptococcus pneumoniae (odds ratio [OR], 4.40; 95% confidence interval [CI], 1.90 and 10.19) and Haemophilus influenzae (OR, 2.04; 95% CI, 1.38 and 3.02). The risk was higher for the presence of bocavirus and H. influenzae together (OR, 3.61; 95% CI, 1.90 and 6.86). Acute otitis media risk differs by the specific viruses and bacteria involved. Acute otitis media prevention efforts should consider methods for reducing infections caused by respiratory syncytial virus, bocavirus, and adenovirus in addition to acute otitis media bacterial pathogens.
MINIMALLY INVASIVE POSTERIOR FIXATION (2008)

Significant advances have been made in the contemporary management of thoracolumbar spinal deformities, including improved segmental bony fixation, techniques for osteotomy, and mechanically powerful reduction maneuvers, which now allow the spinal surgeon to correct severe, complex, and rigid spinal deformities. However, one of the major limitations of surgical intervention has been the high complication rates associated with these surgical endeavors. Much of the morbidity associated with posterior deformity surgery relates to the extensive soft tissue destruction necessary to gain access to multiple segments of the axial skeleton. The open exposures for long-segment fixation result in additional blood loss, increased rates of infection, and prolonged immobilization caused by postoperative pain. Minimally invasive techniques attempt to overcome these drawbacks of the open exposures, and this report reviews preliminary experience in treating spinal deformities with long-segment minimally invasive internal fixation.
A base station correlation-controlled bilateral emulator for MIMO-OTA (2015)

This paper presents a bilateral fading emulator for MIMO-OTA testing with a function of controlling the correlation of base station. On the basis of the Jakes theory, a methodology for achieving the spatial correlation of a base station antenna by setting the initial phases of scatterers in the two-dimensional channel model is introduced. The experimental results show that the designed correlation coefficient of an uplink channel agrees well with the theoretical value, confirming the effectiveness of the proposed method. Using this method, the combined evaluation of a handset MIMO antenna in considerations of both uplink and downlink channel properties can be realized.
Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells (2016)

Acute myeloid leukaemia (AML) is a blood cancer affecting cells of myeloid lineage. It is characterised by rapid growth of malignant leukocytes that accumulate in the bone marrow and suppress normal haematopoiesis. This systemic disease remains a serious medical burden worldwide. Characterisation of protein antigens specifically expressed by malignant cells, but not by healthy leukocytes, is vital for the diagnostics and targeted treatment of AML. Here we report, for the first time, that the neuronal receptor latrophilin-1 is expressed in human monocytic leukaemia cell lines and in primary human AML cells. However, it is absent in healthy leukocytes. Latrophilin-1 is functional in leukaemia cells tested, and its biosynthesis is controlled through the mammalian target of rapamycin (mTOR), a master regulator of myeloid cell translational pathways. Our findings demonstrate that latrophilin-1 could be considered as a novel biomarker of human AML, which offers potential new avenues for AML diagnosis and treatment.
Plastic Deformation of Silicon Nitride Nano-Ceramics (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Drug Resistance Patterns, Genetic Subtypes, Clinical Features, and Risk Factors in Military Personnel with HIV-1 Seroconversion (1999)

The percentage of HIV-1 non-subtype B infection and antiretroviral drug-resistant mutations was relatively high in U.S. military personnel with recently acquired HIV-1 infection.
B‐cell chronic lymphocytic leukaemia cells show specific changes in membrane protein expression during different stages of cell cycle (2007)

The proliferating component in chronic lymphocytic leukaemia (CLL) is usually small (<1%) and restricted to a specific micro-environmental niche. To characterize the proliferating component, CLL cells from bone marrow or lymph nodes of 23 patients were assessed for expression of up to 66 surface antigens in combination with nuclear Ki-67/MCM6. Ki-67 expression was associated with step-wise increases in CD23/CD95/CD86/CD39/CD27 and decreases in CD24/CD69/CXCR4/CXCR5. Ki-67+ cells showed increased CD38 expression, but with considerable inter-patient variability: in some cases Ki-67 expression was only detectable in CD38- CLL cells. The results suggest continuous re-entry into the cell cycle as no distinct stem cell pool was detectable.
Osteonecrosis in Inflammatory Bowel Disease (2005)

Purpose: Osteonecrosis, or avascular necrosis (AVN), is a rare complication of inflammatory bowel disease (IBD). We sought to characterize the relationship between AVN, IBD, and corticosteroid therapy. Methods: A centralized diagnostic index identified all patients (pts) with IBD and AVN evaluated at Mayo Clinic Rochester between 1976 and 2003. Medical records were abstracted for pt demographics, subtype and duration of IBD, treatment received including corticosteroids, other potential AVN risk factors, AVN stage and joints involved, and AVN treatment and outcomes. Results: We identified 52 ulcerative colitis patients (71% male) and 42 Crohn's disease patients (52% male). Median age at AVN diagnosis (dx) was 45.9 years (yrs) (range, 16.5–82.2), and median duration from IBD to AVN dx was 9.2 yrs (0.5–41.2). Of all 94 pts, only 6 pts (6%) had no history of systemic corticosteroid exposure. Steroid-naïve IBD-AVN pts were older at both IBD dx (51.8 yrs) and AVN dx (67.3 yrs) than steroid users. All 88 steroid users had received oral corticosteroids, and 26 had also received IV steroids (24%). Among pts with available data, median cumulative duration of steroid therapy prior to AVN dx was 12.2 months (range, 2–70.2), median daily prednisone dose was 20.4 mg (12.1–50), and median cumulative prednisone dose was 9,205 mg (2,770–42,660). Overall, 41% had a prior arthropathy and 40% had a history of smoking, with similar rates for those with and without corticosteroid use. The mean number of joints involved was 2.3 among those who had received steroids (55% femoral head, 23% upper extremities) versus 1.2 among those who had not (57% femoral head, 0% upper extremities). The prevalence of stage III-IV AVN was 77% in steroid users versus 67% in the steroid-naïve. Median follow-up time after AVN dx was 4.4 yrs (0–27.3). Treatment included arthroplasty in 36%, conservative therapy in 20%, core decompression in 10%, and bone grafting in 7%. Despite treatment, 16% of pts developed worsening symptoms, and 17% had AVN involvement of new joints—none of this progression was seen in the 6 steroid-naïve pts. Conclusions: Osteonecrosis is a rare but serious complication seen in IBD. In a minority of pts, AVN may occur in the absence of corticosteroid therapy. These pts are older at IBD and AVN dx, have fewer joints involved, and have less progression of the joint disease. The etiology of AVN may be multifactorial with contributions from IBD itself, systemic corticosteroid therapy, and other AVN risk factors.
HAMMER: boosting fidelity of noisy Quantum circuits by exploiting Hamming behavior of erroneous outcomes (2022)

Quantum computers with hundreds of qubits will be available soon. Unfortunately, high device error-rates pose a significant challenge in using these near-term quantum systems to power real-world applications. Executing a program on existing quantum systems generates both correct and incorrect outcomes, but often, the output distribution is too noisy to distinguish between them. In this paper, we show that erroneous outcomes are not arbitrary but exhibit a well-defined structure when represented in the Hamming space. Our experiments on IBM and Google quantum computers show that the most frequent erroneous outcomes are more likely to be close in the Hamming space to the correct outcome. We exploit this behavior to improve the ability to infer the correct outcome.
Identification and Clinical Implications of Novel MYO15A Mutations in a Non-consanguineous Korean Family by Targeted Exome Sequencing (2015)

Mutations of MYO15A are generally known to cause severe to profound hearing loss throughout all frequencies. Here, we found two novel MYO15A mutations, c.3871C>T (p.L1291F) and c.5835T>G (p.Y1945X) in an affected individual carrying congenital profound sensorineural hearing loss (SNHL) through targeted resequencing of 134 known deafness genes. The variant, p.L1291F and p.Y1945X, resided in the myosin motor and IQ2 domains, respectively. The p.L1291F variant was predicted to affect the structure of the actin-binding site from three-dimensional protein modeling, thereby interfering with the correct interaction between actin and myosin. From the literature analysis, mutations in the N-terminal domain were more frequently associated with residual hearing at low frequencies than mutations in the other regions of this gene. Therefore we suggest a hypothetical genotype-phenotype correlation whereby MYO15A mutations that affect domains other than the N-terminal domain, lead to profound SNHL throughout all frequencies and mutations that affect the N-terminal domain, result in residual hearing at low frequencies. This genotype-phenotype correlation suggests that preservation of residual hearing during auditory rehabilitation like cochlear implantation should be intended for those who carry mutations in the N-terminal domain and that individuals with mutations elsewhere in MYO15A require early cochlear implantation to timely initiate speech development.