gebhart/patrepeval huggingface dataset:
A low-cost reliable online noise level estimation for accurate spike detection in extracellular recordings (2012)

On-line unsupervised spike detection is a fundamental building block for autonomous neural implants. To accurately monitor neurological activity, the spike detectors should be able to operate at a wide range of firing rates. This can only be achieved by a careful estimation of instantaneous noise level in the recording. In this paper, we propose a system for estimating noise level in extracellular recordings, which is reliable across a wide range of firing rates, and thus leads to accurate spike detection.
Energy-efficient and QoE-driven adaptive HTTP streaming over LTE (2014)

LTE networks offer broadband wireless access to mobile users who can benefit from high data rate applications such as video streaming. In order to improve the user satisfaction, Quality-of-Experience (QoE) based resource allocation for multiple streaming users in an LTE cell has been studied. However, the high energy consumption of these applications has not been considered. In this paper, we propose adaptive Discontinuous Reception (DRX) parameters for LTE that reduce the energy consumption of mobile devices without degrading the video quality of adaptive HTTP streaming users. Furthermore, we extend the QoE-optimized resource allocation by additionally considering the power consumption of the mobile devices. Simulation results show the benefits of using the proposed adaptive DRX parameters and that further energy saving gains can be achieved by including the power consumption in the optimization problem.
1,1'-Diiodo-3,3'-bis(trimethylsilyl)ferrocene (1999)

In the structure of the title compound, [Fe(C 8 H 12 ISi) 2 ], the cyclopentadienyl rings are fully eclipsed. The trimethylsilyl groups are staggered by 141.0(4)° and the iodo groups by 69.6 (3)°.
Multiple mechanical valve replacement surgery comparison of St. Jude Medical and CarboMedics prostheses (1998)

The performance of the CarboMedics and St. Jude Medical prostheses in multiple valve replacement surgery in this non-randomized prospective study revealed no significant differences in performance with regard to thromboembolic and hemorrhagic complications.
“The Lyric a Form / of Shame Management?” (2018)

I’ve often wondered about shame, in all its various allotropes and guises, and about its connection with my poetry. This is because it looms larger in my experience, I think, than for many people. As a child I was cripplingly shy, embarrassable and highly susceptible to tears – I could find myself blushing furiously and my eyes watering at nothing more than having to walk past someone in the street, humiliated by a sense of vulnerability to their gaze and their physical closeness. That hypersensitivity extended to the more usual sources of shame. As a rank conformist at school, I largely avoided punishment, but when it did happen, in an era of corporal punishment, it would reduce me to a quivering, pink-faced wreck. I could easily have believed back then, with Edmund Talbot in William Golding’s Rites of Passage, that it is possible “to die of shame.” This intensity of response was matched by the variety of forms shame could take, at my parents asking about a film (“Lord Jim”) my friend’s parents had taken me to (it had a brief topless episode, which I hadn’t even noticed), or in sympathy at my Mum’s mortification when a shop refused her check, or at Enid Blyton’s toe-curling use of the word “dear” (“her dear red shoes”). In each case, a powerful, involuntary physical response – flush, trembling, blushing, tears – would accompany the emotion.
Ubiquitin Proteasome Pathway annotation in Diaphorina citri can reveal potential targets for RNAi based pest management (2021)

Ubiquitination is an ATP-dependent process that targets proteins for degradation by the proteasome. In this study, we annotated 15 genes from the ubiquitin-proteasome pathway in the Asian citrus psyllid, Diaphorina citri. This psyllid vector has come to prominence in the last decade due to its role in the transmission of the devastating bacterial pathogen, Candidatus Liberibacter asiaticus (CLas). Infection of citrus crops by this pathogen causes Huanglongbing (HLB or citrus greening disease) and results in the eventual death of citrus trees. The identification and correct annotation of these genes in D. citri will be useful for functional genomic studies that aid in the development of RNAi-based management strategies aimed at reducing the spread of HLB. Investigating the effects of CLas infection on the expression of ubiquitin-proteasome pathway genes may provide new information regarding the role that these genes play in the acquisition and transmission of CLas by D. citri.
Plastic Materials (2018)

No AccessPlastics HandbookJan 2019Plastic MaterialsErwin Baur, Tim A. Osswald, Natalie RudolphErwin Baur, Tim A. Osswald, Natalie Rudolphhttps://doi.org/10.3139/9781569905609.005SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2018Pages: 337-578Print ISBN: 978-1-56990-559-3eISBN: 978-1-56990-560-9 Copyright & Permissions© 2019 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Refugee Law Clinic Regensburg – das erste Jahr (2017)

Abstract: Law clinics sind Trend in Deutschland. Zum Teil entspringen sie juristischen Lehrstühlen, zum Teil studentischer Eigeninitiative. Aufgrund der aktuellen migrationspolitischen Situation ist das Asyl- bzw. Migrationsrecht hierzulande das wichtigste Betätigungsfeld der clinics. Die derzeit um die dreißig deutschen Refugee Law Clinics unterscheiden sich in ihrer Konzeption mitunter beträchtlich. Das im Beitrag vorgestellte Regensburger Modell weist in mehrerlei Hinsicht Besonderheiten auf. Die Erwägungen bei der Ausgestaltung der Regensburger law clinic werden deshalb im Beitrag ausführlich dargestellt. Eingegangen wird insbesondere auf die organisatorische Ummantelung der clinic, die Ausbildung und Betreuung der Studierenden sowie – in einem Ausblick – die Möglichkeiten zur strategischen Prozessführung.
Surface Damage Versus Tibial Polyethylene Insert Conformity: A Retrieval Study (2012)

The selection of materials with high fatigue resistance may be particularly important for high-conformity/constraint tibial inserts. In addition, awareness of the benefits and trade-offs with conformity may allow better matching of TKA design to patient.
THE SCIENCE AND PRACTICE OF ERECTION PHYSIOLOGY: STORY OF A REVOLUTIONARY GASEOUS MOLECULE. (2019)

The field of sexual medicine, in reference to the science of the sexual response and the clinical management of sexual dysfunctions, has evolved remarkably in the last 25 years. Erection biology has been central in driving this progress and is measured considerably by the discovery, study, and clinical translation of a simple gaseous molecule, nitric oxide, which is operative in the penis. Nitric oxide functions extraordinarily as a neurotransmitter and molecular signal transducer. It is now well understood to be the principal molecular mediator of penile erection and to be a critical element involved in dysregulatory mechanisms of erection disorders ranging from erectile dysfunction to priapism. It is most familiarly associated with the scientific development of oral medications for treating erectile dysfunction, which has modernized the clinical management of this condition.
Enhancement of Reducibility and Oxygen Storage Capacity (OSC) of Ce–Fe Mixed Oxides by Repetitive Redox Treatment (2012)

Abstract The reduction properties and oxygen storage capacity (OSC) of Ce–Fe mixed oxide (Ce/Fe = 4/1) were investigated. When TPR/OSC cycle was repeated, Ce–Fe mixed oxide gave a new reduction peak at 600 °C, suggesting the enhancement of the reducibility of iron ions. This was accounted by the formation of a solid solution and the participation of Fe2O3 as catalyst for the reduction of Ce–Fe mixed oxide.
Study of cross‐sections of magnetite thin films by means of electron backscatter diffraction (EBSD) (2008)

Abstract By means of electron backscatter diffraction (EBSD), we studied the grain orientation of cross‐sections of magnetite (Fe 3 O 4 ) thin films grown on (001) oriented MgO substrates. Earlier studies showed that the magnetic properties of the magnetite films are dominated by the presence of so‐called anti‐phase boundaries (APBs). The use of cross‐sections of thin‐films enables to study the growth mechanism in a more direct way. The EBSD maps reveal that the first magnetite layer on the MgO substrate is comprised of many small, misoriented magnetite grains. Subsequent layers show the desired (001) orientation with a ±5° misorientation. The misorientations found in the cross‐section of the film resemble those obtained in EBSD measurements at the sample surface. (© 2008 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis (2017)

Bacterial sepsis triggers robust activation of the complement system with subsequent generation of anaphylatoxins (C3a, C5a) and the terminal complement complex (TCC) that together contribute to organ failure and death. Here we tested the effect of RA101295, a 2-kDa macrocyclic peptide inhibitor of C5 cleavage, using in vitro whole-blood assays and an in vivo baboon model of <i>Escherichia coli</i> sepsis. RA101295 strongly inhibited <i>E. coli-</i>induced complement activation both in vitro and in vivo by blocking the generation of C5a and the soluble form of TCC, sC5b-9. RA101295 reduced the <i>E. coli-</i>induced <i>"</i>oxidative burst," as well as leukocyte activation, without affecting host phagocytosis of <i>E. coli</i> RA101295 treatment reduced plasma LPS content in <i>E. coli-</i>challenged baboons, implying reduced complement-mediated bacteriolysis, whereas treated animals showed slightly improved bacterial clearance during the bacteremic stage compared with controls. Treatment with RA101295 also improved consumptive coagulopathy and preserved endothelial anticoagulant and vascular barrier functions. RA101295 abolished sepsis-induced surges in proinflammatory cytokines and attenuated systemic circulatory and febrile responses, likely reflecting decreased systemic levels of LPS and C5a. Overall, RA101295 treatment was associated with significant organ protection and markedly reduced mortality compared with nontreated controls (four of five animals survived in a 100% lethal model). We therefore conclude that inhibition of C5 cleavage during the bacteremic stage of sepsis could be an important therapeutic approach to prevent sepsis-induced inflammation, consumptive coagulopathy, and subsequent organ failure and death.
Improving sensitivity of the connective tissue disease screening questionnaire: A comparative study of various scoring methods (2020)

The adapted CSQ with the classification criteria-based scoring achieved relatively high sensitivities in detecting autoimmune rheumatic diseases, suggesting this could be employed as the first step in population screening.
Translational neurocardiology: preclinical models and cardioneural integrative aspects (2016)

Neuronal elements distributed throughout the cardiac nervous system, from the level of the insular cortex to the intrinsic cardiac nervous system, are in constant communication with one another to ensure that cardiac output matches the dynamic process of regional blood flow demand. Neural elements in their various 'levels' become differentially recruited in the transduction of sensory inputs arising from the heart, major vessels, other visceral organs and somatic structures to optimize neuronal coordination of regional cardiac function. This White Paper will review the relevant aspects of the structural and functional organization for autonomic control of the heart in normal conditions, how these systems remodel/adapt during cardiac disease, and finally how such knowledge can be leveraged in the evolving realm of autonomic regulation therapy for cardiac therapeutics.
Chemical Space Exploration with Active Learning and Alchemical Free Energies (2022)

Drug discovery can be thought of as a search for a needle in a haystack: searching through a large chemical space for the most active compounds. Computational techniques can narrow the search space for experimental follow up, but even they become unaffordable when evaluating large numbers of molecules. Therefore, machine learning (ML) strategies are being developed as computationally cheaper complementary techniques for navigating and triaging large chemical libraries. Here, we explore how an active learning protocol can be combined with first-principles based alchemical free energy calculations to identify high affinity phosphodiesterase 2 (PDE2) inhibitors. We first calibrate the procedure using a set of experimentally characterized PDE2 binders. The optimized protocol is then used prospectively on a large chemical library to navigate toward potent inhibitors. In the active learning cycle, at every iteration a small fraction of compounds is probed by alchemical calculations and the obtained affinities are used to train ML models. With successive rounds, high affinity binders are identified by explicitly evaluating only a small subset of compounds in a large chemical library, thus providing an efficient protocol that robustly identifies a large fraction of true positives.
Human antibody conjugates of potential utility for prostate cancer therapy: A comparison of MGBA conjugates with antibodies targeting a cell surface target (prostate-specific membrane antigen) and an extracellular matrix target (Mindin/RG-1) (2008)

AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA

4062 

Human antibodies have been generated to two tumor-associated antigens of potential interest in prostate cancer. Both of these targets are highly expressed in prostate cancer, but with different distribution patterns. Prostate-specific membrane antigen (PSMA) has been highly validated as an antigen up-regulated on the surface of prostate cancer cells, whereas mindin/RG-1 is an extracellular protein believed to be retained within the extracellular matrix of human prostate tumors and their metastases (Parry et al. , 2005, Cancer Res. 65, 8397-8405). High affinity human antibodies to both proteins have been isolated from transgenic mice, and conjugates linked to synthetic DNA minor-groove binding alkylating (MGBA) agents have been prepared. Anti-PSMA antibody internalizes rapidly into LNCaP cells, but anti-mindin/RG-1 does not internalize in in vitro assays as expected. The two conjugates have been compared in vivo in two different subcutaneous xenograft models, one using LNCaP cells and the other using a co-culture of LNCaP with stromal cells. Data is complicated by the secretion of some mindin/RG-1 by LNCaP cells themselves, however, the anti-mindin/RG-1 conjugate clearly shows improved efficacy in the animal model including stromal cells. The anti-PSMA conjugate shows efficacy in both models, although is active at lower doses in the absence of the stromal cell component. Alternative animal model studies are ongoing in attempts to further understand the differences achieved in anti-tumor response by the two approaches.
Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications (2021)

Gelatin based adhesives have been used in the last decades in different biomedical applications due to the excellent biocompatibility, easy processability, transparency, non-toxicity, and reasonable mechanical properties to mimic the extracellular matrix (ECM). Gelatin adhesives can be easily tuned to gain different viscoelastic and mechanical properties that facilitate its ocular application. We herein grafted glycidyl methacrylate on the gelatin backbone with a simple chemical modification of the precursor, utilizing epoxide ring-opening reactions and visible light-crosslinking. This chemical modification allows the obtaining of an elastic protein-based hydrogel (GELGYM) with excellent biomimetic properties, approaching those of the native tissue. GELGYM can be modulated to be stretched up to 4 times its initial length and withstand high tensile stresses up to 1.95 MPa with compressive strains as high as 80% compared to Gelatin-methacryloyl (GeIMA), the most studied derivative of gelatin used as a bioadhesive. GELGYM is also highly biocompatible and supports cellular adhesion, proliferation, and migration in both 2 and 3-dimensional cell-cultures. These characteristics along with its super adhesion to biological tissues such as cornea, aorta, heart, muscle, kidney, liver, and spleen suggest widespread applications of this hydrogel in many biomedical areas such as transplantation, tissue adhesive, wound dressing, bioprinting, and drug and cell delivery.
ChemInform Abstract: An Efficient Multigram Synthesis of Monomers for the Preparation of Novel Oligonucleotides Containing Isosteric Non‐Phosphorous Backbones. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Can We Predict the Occurrence of Postoperative Nausea and Vomiting? (2017)

術後悪心・嘔吐は，麻酔関連合併症の中で最も頻度が高く，また重篤な病態を惹起する危険性がある．その原因はさまざまな要因が指摘され，また嘔吐に関わる伝達経路も複数存在している．世界的にはこれらのさまざまな伝達経路に対処可能な制吐薬あるいは嘔吐予防薬が開発されているものの，わが国においては保険適用が限定され，高額な制吐薬を術後悪心・嘔吐には処方できない状況にある．今後は術後悪心・嘔吐を併発しやすい患者群をより精度の高い評価法や非侵襲的指標により把握し，効率的に予防することが望まれる．
On the Coverage Extension and Capacity Enhancement of Inband Relay Deployments in LTE‐Advanced Networks (2010)

Decode‐and‐forward relaying is a promising enhancement to existing radio access networks and is currently being standardized in 3GPP to be part of the LTE‐Advanced release 10. Two inband operation modes of relay nodes are to be supported, namely Type 1 and Type 1b. Relay nodes promise to offer considerable gain for system capacity or coverage depending on the deployment prioritization. However, the performance of relays, as any other radio access point, significantly depends on the propagation characteristics of the deployment environment. Hence, in this paper, we investigate the performance of Type 1 and Type 1b inband relaying within the LTE‐Advanced framework in different propagation scenarios in terms of both coverage extension capabilities and capacity enhancements. A comparison between Type 1 and Type 1b relay nodes is as well presented to study the effect of the relaying overhead on the system performance in inband relay node deployments. System level simulations show that Type 1 and Type 1b inband relay deployments offer low to very high gains depending on the deployment environment. As well, it is shown that the effect of the relaying overhead is minimal on coverage extension whereas it is more evident on system throughput.
Cabazitaxel-Loaded Nanocarriers for Cancer Therapy with Reduced Side Effects (2019)

Jevtana<sup>®</sup> is a micellar cabazitaxel (CBZ) solution that was approved for prostate cancer in 2010, and recently, this drug has been reported for breast cancer. The purpose of this study is to evaluate the mediated delivery of CBZ via liposomes and nanoparticles (NPs) for the treatment of breast cancer and compare these with a micellar formulation that is currently in clinical use. CBZ-loaded nanocarriers were prepared with particle sizes between 70⁻110 nm, and with the sustained in vitro release of CBZ for more than 28 days. Cytotoxicity studies on MCF-7 and MDA-MB-231 cells demonstrated the toxic potential of these nanocarriers. Cellular internalization revealed that NPs and liposomes have better permeability than micelles. Cell cycle analysis and apoptosis studies on MCF-7 and MDA-MB-231 cells confirmed G2/M phase arrest as well as cell death due to apoptosis and necrosis, where formulations were found to be effective compared to a micellar CBZ solution. Results from pharmacokinetic studies revealed that there is an increased circulation half-life and mean residence time for CBZ liposomes and NPs in comparison with a micellar CBZ solution. CBZ liposomes and NPs showed a reduction in hemolysis and neutropenia in comparison with a micellar CBZ solution in rats.
Kallikrein/kinin protects against gentamicin-induced nephrotoxicity by inhibition of inflammation and apoptosis (2006)

This study indicates that kallikrein/kinin protects against gentamicin-induced nephrotoxicity by inhibiting inflammatory cell recruitment and apoptosis through suppression of oxidative stress-mediated signalling pathways. These findings raise the potential of applying kallikrein therapy approaches in treating aminoglycoside-induced renal damage.
ChemInform Abstract: Improved Enantioselective Dihydroxylation of Bishomoallylic Alcohol Derivatives Using a Mechanistically Inspired Bis‐cinchona Alkaloid Catalyst. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Kinetic resolution and parallel kinetic resolution of methyl (±)-5-alkyl-cyclopentene-1-carboxylates for the asymmetric synthesis of 5-alkyl-cispentacin derivatives (2005)

Conjugate addition of lithium dibenzylamide to methyl 5-isopropyl, 5-phenyl- and 5-tert-butyl-cyclopentene-1-carboxylates occurs with high levels of substrate control (>88% de), with preferential addition to the face of the cyclic alpha,beta-unsaturated acceptor anti- to the stereodirecting 5-alkyl substituent. Treatment of a range of methyl (+/-)-5-alkyl-cyclopentene-1-carboxylates with both lithium (+/-)-N-benzyl-N-alpha-methylbenzylamide and lithium (+/-)-N-3,4-dimethoxybenzyl-N-alpha-methylbenzylamide indicates significant enantiorecognition in their mutual kinetic resolutions, with preferential addition anti- to the 5-alkyl substituent, giving the 1,2-syn-1,5-anti-arrangement (E >16) after enolate protonation anti- to the amino functionality. The kinetic resolution of a range of methyl (+/-)-5-alkyl-cyclopentene-1-carboxylates with lithium (S)-N-benzyl-N-alpha-methylbenzylamide, and their efficient parallel kinetic resolution with a pseudoenantiomeric mixture of lithium (S)-N-benzyl-N-alpha-methylbenzylamide and lithium (R)-N-3,4-dimethoxybenzyl-N-alpha-methylbenzylamide are also demonstrated, giving a range of 5-alkyl-cispentacin derivatives in >98% de and high ee after N-deprotection.
Bus Door System Considerations for Aging and Physically Challenged Populations (2005)

The bus doors are the first and last vehicle system encountered by a rider. Door systems have evolved over time in response to changes in operating practices, vehicle designs and accessibility requirements. Some of the evolutionary changes have had unintended consequences for riders, and, in particular, for Aging, Physically Challenged and Temporarily Challenged riders. This paper summarizes key aspects of contemporary transit bus door systems, explores the implications for riders of characteristics such as door geometry and opening size, and suggests approaches to enhance the interaction between bus doors and special rider populations.