gebhart/patrepeval huggingface dataset:
Post‐stroke treatment with imidapril reduces learning deficits with less formation of brain oedema in a stroke‐prone substrain of spontaneously hypertensive rats (1999)

The present study was undertaken to examine the effects of the ACE (angiotensin converting enzyme) inhibitor imidapril, on the brain, when administered after the onset of stroke in a stroke-prone substrain of spontaneously hypertensive rats (SHRSP). Learning deficits and induced lesions in the brain as well as in the kidneys and heart were investigated in detail. SHRSP were divided into two groups with or without salt loading at the age of 4 weeks. The salt loading was performed for 7-9 weeks to increase the incidence of stroke. Within 24 h after the first observation of stroke, animals were subsequently treated with 5 mg/kg imidapril orally once a day or the vehicle for up to the age of 27 weeks. Imidapril attenuated progression of neurological abnormalities such as irritability, hyperkinesia and motor dysfunction, and increased survival rate. In three-panel runway testing, learning deficits did not develop significantly in the imidapril-treated group, and was comparable to that in the non-salt-loaded/non-stroke group. Imidapril reduced oedema formation in the cortex, hippocampus and striatum, and also suppressed lesion formation in the kidneys and heart. Imidapril thus suppressed progression of neurological deficits with loss of learning ability following onset of stroke, and also suppressed formation of oedema in the brain and decreased the number of lesions in other organs. Imidapril-induced reduction of cerebrovascular damage, which presumably occurs in the brain after stroke, may account for the inhibitory effects of imidapril on lesion formation and learning impairment.
An Italian survey of severe head trauma management during extracranial surgery (2005)

More widespread knowledge of certain areas of severe head trauma management such as early tracheal intubation, avoidance of prophylactic hyperventilation, adequate invasive monitoring, appropriate use of blood products, and timing of transfer to hospitals with neurosurgical facilities is needed.
Observing Ion Motion in Conjugated Polyelectrolytes with Kelvin Probe Force Microscopy (2017)

Conjugated polyelectrolytes (CPEs) are polymer semiconductors whose properties are affected by the presence of covalently fixed and mobile ions. These structural components lead to interfacial dipoles, electrochemical doping, and mixed ionic and electronic conductivity. While the behavior of ionic carriers is important to a number of CPE applications, it remains difficult to quantify ion transport in films due to interference from electronic carriers; relationships between molecular structure and ion conductivity are thus not well understood. This work demonstrates direct observation of ions in six different CPE films using Kelvin probe force microscopy. Surface potential measurements of thin, planar CPE device structures are used to map the distribution of ions through the simple electrostatic relationship between potential and charge density. The transport of mobile ions within the CPE bulk can be studied through the time‐dependent relaxation of bias‐stressed CPE films, through which the decay of ion populations near each electrode is measured and carefully modeled, leading to estimated values of ionic mobility and effective ionic carrier density. The results show that ion transport is most strongly impacted by the number of ion‐bearing side chains per monomer, which facilitate room temperature ion transport via vibrational motion.
Breast Cancer and factors of existential anxiety (2003)

In the population in general, breast cancers are today the most frequently mentioned malignant disease. Therefore, it is necessary to develop certain psycho-educational systems for the female population, with the purpose of preventing breast cancer. The original data have been analysed by multivariant methods of extraction of the major components i.e. trends of changes. In the field of latent existential anxiety it was thus possible to condense 11 most frequent associations – . An evaluation of the obtained results confirmed the importance of the preventive psycho-educational program BREAST AWARENESS / CORPUS MYSTICUM for the development of habits and concern for one's own body in the female population.
Serum of patients with active rheumatoid arthritis inhibits differentiation of osteochondrogenic precursor cells (2016)

Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Identification of a new tissue-kallikrein-binding protein (1986)

We have identified a tissue-kallikrein-binding protein in human serum and in the serum-free culture media from human lung fibroblasts (WI-38) and rodent neuroblastoma X glioma hybrid cells (NG108-15). Purified and 125I-labelled tissue kallikrein and human serum form an approximately 92,000-Mr SDS-stable complex. The relative quantity of this complex-formation is measured by densitometric scanning of autoradiograms. Complex-formation between tissue kallikrein and the serum binding protein was time-dependent and detectable after 5 min incubation at 37 degrees C, with half-maximal binding at 28 min. Binding of 125I-kallikrein to kallikrein-binding protein is temperature-dependent and can be inhibited by heparin or excess unlabelled tissue kallikrein but not by plasma kallikrein, collagenase, thrombin, urokinase, alpha 1-antitrypsin or kininogens. The kallikrein-binding protein is acid- and heat-labile, as pretreatment of sera at pH 3.0 or at 60 degrees C for 30 min diminishes complex-formation. However, the formed complexes are stable to acid or 1 M-hydroxylamine treatment and can only be partially dissociated with 10 mM-NaOH. When kallikrein was inhibited by the active-site-labelling reagents phenylmethanesulphonyl fluoride or D-Phe-D-Phe-L-Arg-CH2Cl no complex-formation was observed. An endogenous approximately 92,000-Mr kallikrein-kallikrein-binding protein complex was isolated from normal human serum by using a human tissue kallikrein-agarose affinity column. These complexes were recognized by anti-(human tissue kallikrein) antibodies, but not by anti-alpha 1-antitrypsin serum, in Western-blot analyses. The results show that the kallikrein-binding protein is distinct from alpha 1-antitrypsin and is not identifiable with any of the well-characterized plasma proteinase inhibitors such as alpha 2-macroglobulin, inter-alpha-trypsin inhibitor, C1-inactivator or antithrombin III. The functional role of this kallikrein-binding protein and its impact on kallikrein activity or metabolism in vivo remain to be investigated.
A survey and analysis of TLS interception mechanisms and motivations (2020)

TLS is an end-to-end protocol designed to provide confidentiality and integrity guarantees that improve end-user security and privacy. While TLS helps defend against pervasive surveillance of intercepted unencrypted traffic, it also hinders several common beneficial operations typically performed by middleboxes on the network traffic. Consequently, various methods have been proposed that "bypass" the confidentiality goals of TLS by playing with keys and certificates essentially in a man-in-the-middle solution, as well as new proposals that extend the protocol to accommodate third parties, delegation schemes to trusted middleboxes, and fine-grained control and verification mechanisms. We first review the use cases expecting plain HTTP traffic and discuss the extent to which TLS hinders these operations. We retain 19 scenarios where access to unencrypted traffic is still relevant and evaluate the incentives of the stakeholders involved. Second, we survey 30 schemes by which TLS no longer delivers end-to-end security, and by which the notion of an "end" changes, including caching middleboxes such as Content Delivery Networks. Finally, we compare each scheme based on deployability and security characteristics, and evaluate their compatibility with the stakeholders' incentives. Our analysis leads to a number of key findings, observations, and research questions that we believe will be of interest to practitioners, policy makers and researchers.
A Reconfigurable Spectrum-Compressing Receiver for Non-Contiguous Carrier Aggregation in CMOS SOI (2019)

This article demonstrates a signal processing technique for receiving non-contiguous RF channels by concurrently mixing several RF bands to adjacent IF channels. Consequently, channel selection does not require local oscillator tuning and the proposed receiver (RX) can switch channels in less than 25 ns. The RX chip operates over a frequency range of 100 MHz-1.4 GHz and demonstrates an out-of-band rejection of 49 dB and a measured RX sensitivity of -86 dBm, which is the lowest measured for N-path-based RXs. The chip was fabricated in a 45-nm RF silicon-on-insulator (SOI) CMOS process and occupies an active area of 0.55 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> with the power consumption of 23.1 mW when operating at 1 GHz. The chip performance is verified with over-the-air measurement of two transmitted signals 80 MHz apart that are received simultaneously with a 10-MHz analog-to-digital converter (ADC) at an error vector magnitude (EVM) around -20 dB. The measured dynamic range for EVM less than -20 dB is better than 86 dB for a QPSK constellation.
Fundamental Domains for Symmetric Optimization: Construction and Search (2021)

Symmetries of a set are linear transformations that map the set to itself. A fundamental domain of a symmetric set is a subset that contains at least one representative from each of the symmetric equivalence classes (orbits) in the set. This paper contributes a novel polynomial algorithm for constructing minimal polytopic fundamental domains of polytopic sets. Our algorithm is applicable for generic linear symmetries of the set and has linear complexity in the number of facets and dimension of the symmetric polytope, e.g., the feasible region of an optimization problem. In addition, this paper contributes a novel polynomial algorithm for mapping an element of the polytope to its representative in the fundamental domain. The algorithms are demonstrated in four examples---two illustrative and two practical. In the first practical example, we show that a minimal fundamental domain of the hypercube under the symmetric group is the set of points with sorted elements. In the second practical example, we show how the construction algorithm can be applied to the max-cut problem.
Myristoylation-dependent and Electrostatic Interactions Exert Independent Effects on the Membrane Association of the Myristoylated Alanine-rich Protein Kinase C Substrate Protein in Intact Cells (1996)

The myristoylated alanine-rich protein kinase C substrate (MARCKS) is a widely expressed, prominent substrate for protein kinase C. MARCKS is largely associated with membranes in cells, and hydrophobic interactions involving the amino-terminal myristoyl moiety are thought to play a role in anchoring MARCKS to cellular membranes. In addition, experiments in cell-free systems have suggested that electrostatic interactions between the positively charged phosphorylation site/calmodulin binding domain (PSD) of MARCKS and negatively charged membrane lipids are also involved in this association. Although it has been inferred from phosphorylation experiments, the electrostatic nature of the interaction between the PSD and membranes has not been demonstrated directly in intact cells. We expressed human MARCKS mutated in the myristoylation site and the PSD in REF52 cells; the cells were then fractionated by ultracentrifugation. Both nonmyristoylatable MARCKS and MARCKS in which the four serines in the PSD were mutated to aspartic acids, mimicking phosphorylation, exhibited decreased membrane affinity when compared to the fully myristoylated, wild-type, tetra-Ser protein or a myristoylated, tetra-Asn mutant. A double mutant, nonmyristoylatable protein in which the four serines in the PSD were mutated to aspartic acids exhibited negligible membrane association. Similar results were obtained in 293 cells that stably expressed chicken MARCKS mutated in the same domains. The double mutant, nonmyristoylatable tetra-Asp chicken protein exhibited little membrane association as determined by both subcellular fractionation and immunoelectron microscopy. These results indicate that myristoylation and electrostatic interactions involving the PSD exert independent, essentially additive effects on the membrane association of MARCKS in intact cells.
Childhood Moyamoya Disease: Quantitative Evaluation of Perfusion MR Imaging—Correlation with Clinical Outcome after Revascularization Surgery (2009)

TTP and CBV perfusion maps can depict hemodynamic status after revascularization surgery in moyamoya disease. Furthermore, changes in TTP perfusion maps after revascularization surgery correspond with clinical outcome in patients with moyamoya disease.
Determination of amplicon boundaries at 20q13.2 in tissue samples of human gastric adenocarcinomas by high‐resolution microarray comparative genomic hybridization (2003)

Comparative genomic hybridization (CGH) of gastric adenocarcinomas frequently shows gains and amplifications of chromosome 20. However, the underlying genetic lesion is unknown and conventional CGH results do not allow specification of the target region. In order to investigate this chromosomal aberration with a higher resolution and sensitivity, microarray-based CGH was performed with both scanning and high-resolution arrays of chromosome 20 in a series of 27 gastric adenocarcinomas. Locus-specific fragments of genomic DNA from bacterial artificial chromosome (BAC) clones were spotted as microarrays. A scanning array contained a set of 27 BAC clones covering chromosome 20q. A high-resolution array contained 27 overlapping BAC clones at 20q13.2. This high-resolution array was used to narrow down the amplicon at 20q13.2 in tumours showing amplification of this chromosomal region with the scanning array. Positive copy number changes on chromosome 20q were detected in 12 of 27 cases (44%). These changes included gain of the whole arm of chromosome 20q in 8 of 27 (30%) cases, amplification restricted to 20q12.1 in one case, and amplifications restricted to 20q13 in three cases (11%). The three tumours showing amplification restricted to 20q13 were analysed further using the high-resolution array. In one tumour, the whole contig was amplified at a constant level. One of the other two tumours had a clear proximal breakpoint, while the other tumour had a clear distal breakpoint within the 20q13.2 region. The proximal and the distal breakpoint were approximately 800 kb apart. In the present study, an amplicon at 20q13.2 has been narrowed down to 800 kb which is likely to harbour one or more putative oncogenes relevant to gastric carcinogenesis, for which ZNF217 and CYP24 are good candidates.
Identification of Bacteria-Selective Threonyl-tRNA Synthetase Substrate Inhibitors by Structure-Based Design (2013)

A series of potent and bacteria-selective threonyl-tRNA synthetase (ThrRS) inhibitors have been identified using structure-based drug design. These compounds occupied the substrate binding site of ThrRS and showed excellent binding affinities for all of the bacterial orthologues tested. Some of the compounds displayed greatly improved bacterial selectivity. Key residues responsible for potency and bacteria/human ThrRS selectivity have been identified. Antimicrobial activity has been achieved against wild-type Haemophilus influenzae and efflux-deficient mutants of Escherichia coli and Burkholderia thailandensis.
Are Image-Agnostic Universal Adversarial Perturbations for Face Recognition Difficult to Detect? (2018)

High performance of deep neural network based systems have attracted many applications in object recognition and face recognition. However, researchers have also demonstrated them to be highly sensitive to adversarial perturbation and hence, tend to be unreliable and lack robustness. While most of the research on adversarial perturbation focuses on image specific attacks, recently, image-agnostic Universal perturbations are proposed which learn the adversarial pattern over training distribution and have broader impact on real-world security applications. Such adversarial attacks can have compounding effect on face recognition where these visually imperceptible attacks can cause mismatches. To defend against adversarial attacks, sophisticated detection approaches are prevalent but most of the existing approaches do not focus on image-agnostic attacks. In this paper, we present a simple but efficient approach based on pixel values and Principal Component Analysis as features coupled with a Support Vector Machine as the classifier, to detect image-agnostic universal perturbations. We also present evaluation metrics, namely adversarial perturbation class classification error rate, original class classification error rate, and average classification error rate, to estimate the performance of adversarial perturbation detection algorithms. The experimental results on multiple databases and different DNN architectures show that it is indeed not required to build complex detection algorithms; rather simpler approaches can yield higher detection rates and lower error rates for image agnostic adversarial perturbation.
Anisotropic optical properties of highly doped rutile SnO2: Valence band contributions to the Burstein-Moss shift (2018)

The interband absorption of the transparent conducting semiconductor rutile stannic oxide (SnO2) is investigated as a function of increasing free electron concentration. The anisotropic dielectric functions of SnO2:Sb are determined by spectroscopic ellipsometry. The onsets of strong interband absorption found at different positions shift to higher photon energies with increasing free carrier concentration. For the electric field vector parallel to the optic axis, a low energy shoulder increases in prominence with increasing free electron concentration. We analyze the influence of different many-body effects and can model the behavior by taking into account bandgap renormalization and the Burstein-Moss effect. The latter consists of contributions from the conduction and the valence bands which can be distinguished because the nonparabolic conduction band dispersion of SnO2 is known already with high accuracy. The possible originsof the shoulder are discussed. The most likely mechanism is identified to be interband transitions at |k| &amp;gt; 0 from a dipole forbidden valence band.
Comparative evaluation of monocular augmented-reality display for surgical microscopes (2012)

Medical augmented reality has undergone much development recently. However, there is a lack of studies quantitatively comparing the different display options available. This paper compares the effects of different graphical overlay systems in a simple micromanipulation task with "soft" visual servoing. We compared positioning accuracy in a real-time visually-guided task using Micron, an active handheld tremor-canceling microsurgical instrument, using three different displays: 2D screen, 3D screen, and microscope with monocular image injection. Tested with novices and an experienced vitreoretinal surgeon, display of virtual cues in the microscope via an augmented reality injection system significantly decreased 3D error (p &#60; 0.05) compared to the 2D and 3D monitors when confounding factors such as magnification level were normalized.
Needle Optimization for Wrist-Based Electronic Mosquito Pilot Human Testing (2019)

Diabetes Mellitus is a lifelong condition associated with the inability of the pancreas to produce enough insulin for the body. The World Health Organization estimates that 422 million people globally suffer from diabetes. Numerous methods are available to monitor this condition. However, none of them provides completely autonomous test results. This paper studies needle optimization for an autonomous blood glucose monitoring system known as the Electronic Mosquito, designed to replace standard fingerprick-based testing. The aim is to maximize blood volume collection and to facilitate more reliable glucose level readings while preserving the autonomous nature of the device. Pilot human testing is reported and discussed.
Supplementary Figure 5 from Tasquinimod Modulates Suppressive Myeloid Cells and Enhances Cancer Immunotherapies in Murine Models (2023)

&lt;p&gt;Supplementary Figure 5. The effect of tasquinimod treatment on CD11c+ dendritic cells.&lt;/p&gt;
Andeans: Adapting to High Altitudes Man in the Andes. A Multidisciplinary Study of High-Altitude Quechua P. T. Baker M. A. Little (1979)

Journal Article Andeans: Adapting to High Altitudes Get access Man in the Andes. A Multidisciplinary Study of High-Altitude Quechua, edited by Baker P. T. Little M. A.. Dowden, Hutchinson & Ross, Stroudsburg, PA, 1978, 303 p., $39.50 (76–17025). Richard B. Mazess Richard B. Mazess Depts. of Radiology & Human Oncology, University of Wisconsin, Madison, WI 53706 Search for other works by this author on: Oxford Academic Google Scholar BioScience, Volume 29, Issue 5, May 1979, Page 314, https://doi.org/10.2307/1307831 Published: 01 May 1979
Nonzero structure analysis (1994)

Because the efficiency of sparse codes is very much dependent on the size and structure of input data, peculiarities of the nonzero structures of sparse matrices must be accounted for in order to avoid unsatisfying performance. Usually, this implies retargeting a sparse application to specific instances of the same problem. However, if characteristics of the input data are collected at compile-time and used in the data structure selection and code generation by a compiler that converts dense programs into sparse programs automatically, the complexity of sparse code development can be greatly reduced, and an efficient way for this retargeting results. Such a “sparse compiler” requires an analysis engine, which is the topic of this paper.
Experimental investigation on temperature and strain dependence of brillouin frequency shifts in GeO (2007)

The strain- or temperature-coefficient of Brillouin frequency shift is shown to be a quadratic function of draw-tension during fiber fabrication. The coefficients decrease by 1.48% and 1.61% respectively for a unit mol% increase of GeO2 concentration. (2 pages)
21.7 A 500mW digitally calibrated AFE in 65nm CMOS for 10Gb/s Serial links over backplane and multimode fiber (2009)

The demand for bandwidth has fueled the deployment of 10 Gb/s traffic over legacy data links such as serial backplanes (10GBase-KR) and multimode fiber (10 GBase-MMF) which were originally intended for much lower data rates. Under severe channel impairments, a DSP-based transceiver provides robust performance and enables power/area scaling with processes. This work describes a 65 nm CMOS AFE integrated in a DSP-based PHY for 10 Gb/s KR/MMF applications.
Effects of the ratio of hardness to Young’s modulus on the friction and wear behavior of bilayer coatings (2004)

We present a study of the effects of the ratio of hardness to Young’s modulus on the friction and wear behavior of layered composite coatings. Layered coating structures with the same surface coating but different interlayers were prepared by physical vapor deposition. We found that the ratio of hardness to Young’s modulus plays an important role in determining the friction coefficient and wear resistance of layered composite coatings. A low friction coefficient and high wear resistance can be achieved in structures with high ratio of hardness to Young’s modulus and moderately high hardness.