gebhart/patrepeval huggingface dataset:
SCR of NO with NH3 over Cu/NaZSM-5 and Cu/HZSM-5 in the presence of decane (2009)

The selective catalytic reduction of NO x with NH 3 in the presence of decane over Cu/ZSM-5 catalysts prepared from H + and Na + ZSM-5 precursors were investigated. Cu/NaZSM-5 catalyst showed significantly higher NO x conversion compared to Cu/HZSM-5. However, the presence of decane decreased the activity of both the catalysts, due to coke formation. Cu/HZSM-5 catalyst showed a larger decline in NO x conversion with time on stream compared to Cu/NaZSM-5. The higher activity of Cu/NaZSM-5 is attributed, to the promoting effect of Na + cations in the formation of active Cu + and nitrite and nitrate intermediates species and retardation of coke formation.
Cosmic microwave background probes models of inflation (1992)

Inflation creates both scalar (density) and tensor (gravity wave) metric perturbations. We find that the tensor-mode contribution to the cosmic microwave background anisotropy on large-angular scales can only exceed that of the scalar mode in models where the spectrum of perturbations deviates significantly from scale invariance (e.g., extended and power-law inflation models and extreme versions of chaotic inflation). If the tensor mode dominates at large-angular scales, then the value of \ensuremath{\Delta}T/T predicted on 1\ifmmode^\circ\else\textdegree\fi{} is less than if the scalar mode dominates, and, for cold-dark-matter models, bias factors b&gt;1 can be made consistent with Cosmic Background Explorer Differential Microwave Radiometer results.
Common Genetic Variation in GLP1R and Insulin Secretion in Response to Exogenous GLP-1 in Nondiabetic Subjects (2010)

Variation in GLP1R may alter insulin secretion in response to exogenous GLP-1. Future studies will determine whether such variation accounts for interindividual differences in response to GLP-1-based therapy.
Thermal cyclization of substituted aryl propargyl ethers. Scope of regioselectivity of the reaction in the synthesis of substituted 3-chromenes (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal cyclization of substituted aryl propargyl ethers. Scope of regioselectivity of the reaction in the synthesis of substituted 3-chromenesWayne K. Anderson and Edmond J. LaVoieCite this: J. Org. Chem. 1973, 38, 22, 3832–3835Publication Date (Print):November 1, 1973Publication History Published online1 May 2002Published inissue 1 November 1973https://pubs.acs.org/doi/10.1021/jo00962a004https://doi.org/10.1021/jo00962a004research-articleACS PublicationsRequest reuse permissionsArticle Views384Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
LIN28B promotes the development of neuroendocrine prostate cancer (2020)

Therapy-induced neuroendocrine prostate cancer (t-NEPC) is a highly aggressive subtype of prostate cancer with poor patient survival. Emerging evidence indicates that t-NEPC can develop when prostate adenocarcinoma cells acquire cancer stem-like cell signaling in the presence of androgen receptor inhibition, followed by redifferentiation toward neuroendocrine lineage and subsequent t-NEPC progression. Whether the stem-like signaling is controlled by the core pluripotency stem cell genes (e.g., LIN28 and SOX2) remains unknown. Here, we report that the transcription of the LIN28B isoform and SOX2 were co-upregulated in t-NEPC patient tumors, patient-derived xenografts, transgenic mice, and cell models. Immunohistochemistry validated that LIN28B and SOX2 protein expression were elevated in t-NEPC patient biopsies. Using prostate adenocarcinoma and t-NEPC cell models, we demonstrated that LIN28B induced a stem-like gene network, neuroendocrine biomarkers, and neuroendocrine cell morphology. LIN28B depletion by CRISPR inhibited t-NEPC tumorigenesis and xenograft growth. These LIN28B functions were mediated mainly through the suppression of let-7 miRNA expression, resulting in de-repression of the transcription factor HMGA2 and HMGA2-mediated SOX2 expression. This study revealed a mechanism by which t-NEPC can develop through the LIN28B/let-7/SOX2 axis that regulates a cancer cell stem-like gene network, highlighting LIN28B as a potential therapeutic target in t-NEPC.
Distributed Optimisation with Restricted Exchanges of Information: Charging of en Electric Vehicle Fleet (2018)

International audience
Monitoring Allergen Immunotherapy Effects by Microarray (2016)

Allergen-specific immunotherapy (AIT) is the only treatment of IgE-mediated allergies so far that has a sustained effect on clinical symptoms and can modify the course of the disease. It is an allergen-specific treatment and therefore requires the correct identification of the disease-causing allergens. Furthermore, AIT is a time-consuming treatment for which the efficacy is dependent on several factors. Therefore, diagnostic tests and biomarkers are needed that facilitate (1) selection of the correct allergens according to the patient's individual sensitization profile and (2) to monitor the effects of AIT. This can provide support for the decision to continue, modify, or discontinue vaccination. One significant mechanism of action of AIT is the induction of allergen-specific antibodies that compete with IgE for the binding to allergen molecules, hence referred to as blocking antibodies. It was shown in several studies that the induction of blocking antibodies by AIT, and their specificity can be measured by allergen microarrays. Inhibition of allergen-specific IgE binding by blocking antibodies can also be determined by microarrays and is associated with changes in clinical parameters or other in vivo and in vitro assays demonstrating efficacy of AIT. Furthermore, allergen microarrays allow determination of IgE sensitizations towards a comprehensive set of allergen molecules and therefore are well suited for identifying the disease-causing allergens for correct prescription of AIT. Thus, diagnostic tests based on microarrayed allergens can be useful in determining the correct prescription of AIT and can be used to monitor efficacy of AIT.
A validated high performance liquid chromatography – diode array detector method for the quantification of mitomycin C in plasma, peritoneal fluid and urine (2018)

Mitomycin C (MMC) is a quinone-containing alkylating agent, that has been extensively studied in preclinical and clinical work due to its antitumor activity. A thoroughly validated high performance liquid chromatography-diode array detector method is provided to quantify MMC in plasma, peritoneal fluid and urine. Porfiromycin served as internal standard. The mobile phase for the plasma, peritoneal fluid and urine analysis consisted of 27% MeOH and 73% 20 mM ammoniumacetate buffer (pH 6.5) and 9% ACN and 91% 20 mM phosphate buffer (pH 6.5) respectively. The residue from 100 µL ACN deproteinated plasma was dissolved in 250 µL mobile phase. Peritoneal fluid and urine were diluted 10-fold in their respective mobile phases. UV detection was performed at 365 nm. Quantification of MMC was achieved over a linear range of 0.05–5 µg/mL and 5–50 µg/mL in plasma; 0.1–5 µg/mL and 5–100 µg/mL in peritoneal fluid; 0.25–5 µg/mL and 5–100 µg/mL in urine. The limit of quantification was 0.05 µg/mL in plasma, 0.1 µg/mL in peritoneal fluid and 0.25 µg/mL in urine. The method was further validated for selectivity, specificity, inter- and intraday precision and accuracy (≤15%), extraction recovery and stability. MMC remains stable in the different biofluids for 20 days (short-term stability) at 4 °C, −27 °C and −80 °C and for 80 days (long-term stability) at −80 °C.
Asymmetric Synthesis of a (2Z,7E)-Cyclononadiene by an Intramolecular Cycloalkylation and Insight to Its Conformational Properties (2000)

Here, we report a novel synthesis of a monosubstituted, enantio- and diastereomerically enriched trans-cyclononadienol. The reaction consists of an enantioselective (-)-sparteine-mediated allylic lithiation of an achiral 7-chlorononadienyl carbamate and a subsequent stereospecific intramolecular allyllithium-allyl chloride coupling. The stereochemical course of the cyclization has been determined, and the high configurative stability of the chiral nine-membered carbocycle has been investigated by kinetic measurements and rationalized by computational calculations.
Vapor-liquid equilibria for binary mixtures of butyl ether with 2-furaldehyde and with 2-, 3-, and 4-heptanone (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVapor-liquid equilibria for binary mixtures of butyl ether with 2-furaldehyde and with 2-, 3-, and 4-heptanoneHuey S. Wu and Stanley I. SandlerCite this: J. Chem. Eng. Data 1988, 33, 3, 316–321Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/je00053a027https://doi.org/10.1021/je00053a027research-articleACS PublicationsRequest reuse permissionsArticle Views108Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Growth Behavior of a Crack Parallel to a Weld Line between Two Different Steels. (Effect of Crack Position on Fracture Mode). (2000)

It was shown previously that a crack in a weld line between two different steels may cause mode II type fracture, even under so-called mode I type loading, due to the difference of material properties. In this study, the fracture experiments of the specimen in which a crack parallel to a weld line between high-tension steel and mild steel exists in its neighborhood are carried out. It is shown that mode II type fracture occurs when a crack is in the heat affected zone, the fracture mode changes to mode I type with the distance of crack position from the weld line and mode I type fracture occurs when a crack exists in each mother material. After that, finite element analyses corresponding to the experiments are carried out taking material properties in the weld line and heat affected zone into account, and the CED (crack energy density) in an arbitrary direction is evaluated through the results of finite element analyses. The applicability of fracture criterion based on the CED in an arbitray direction is demonstrated to the crack growth initiation behavior of a crack parallel to a weld line between two different steels. Moreover, the effect of inhomogeneity by welding on the fracture resistance with the crack position is investigated based on the CED in an arbitrary direction.
Convergence Testing in Term-Level Bounded Model Checking (2003)

We consider the problem of bounded model checking of systems expressed in a decidable fragment of first-order logic.While model checking is not guaranteed to terminate for an arbitrary system, it converges for many practical examples, including pipelined processors.We give a new formal definition of convergence that generalizes previously stated criteria.We also give a sound semidecision procedure to check this criterion based on a translation to quantified separation logic.Preliminary results on simple pipeline processor models are presented.
Porcine DJ-1: cloning of <i>PARK7</i> cDNA, sequence comparison, expression analysis and chromosomal localization (2007)

The PARK7 gene encodes a protein, DJ-1, with several functions such as protection of cells from oxidative stress, sperm maturation and fertilization and chaperone activity. Mutations in the PARK7 gene are associated with autosomal recessive early-onset Parkinson's disease (Parkinsonism). This work reports the cloning and analysis of the porcine (Sus scrofa) homologue of DJ-1. The porcine PARK7 cDNA was amplified by reverse transcriptase polymerase chain reaction (RT-PCR) using oligonucleotide primers derived from in silico sequences. The porcine PARK7 cDNA (SsPARK7) encodes a protein of 189 amino acids which shows a very high similarity to bovine (97%), to human (96%) and to canine (95%) DJ-1. Protein structure comparison of human and porcine DJ-1 sequences revealed that amino acid changes were few between the two species and not likely to alter DJ-1 structure and function. Quantitative real-time RT-PCR detection exhibited SsPARK7 mRNA expression in all analyzed porcine tissues, although at different levels. Furthermore, expression analysis showed that SsPARK7 transcripts could be detected early in embryo development in different brain regions. The PARK7 gene was demonstrated to be located on porcine chromosome 6. Single-nucleotide polymorphism (SNP) analysis revealed one SNP in the porcine PARK7 gene, giving rise to a silent mutation in exon 6.
Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds (2013)

Diabetes mellitus, characterised by hyperglycemia and altered β-cell function, is an increasingly common disorder affecting millions of individuals world-wide. While therapeutic regimens exist to manage the condition, diabetic individuals remain prone to complications that are detrimental to both their length and quality of life. An improved understanding of the disease which may then enable development of new treatments is therefore a desirable goal. Vesiculin, a novel IGF-II-like protein was recently isolated from the secretory granules of murine β-cells, and preliminary studies indicate it is capable of signalling via the insulin receptor (IR)/insulin-like growth factor receptor 1(IGF1R) family giving it the potential to elicit both metabolic and mitogenic responses in the beta-cell. In order to facilitate further studies on this new member of the insulin-family of hormones, we undertook a chemical synthesis of the protein using regioselective disulfide bond formation.
Hardware intrinsic security from D flip-flops (2010)

In this paper we describe the results of our investigations Supported by EU FP7 project UNIQUE on the randomness and reliability of D flip-flops when used as a Physically Unclonable Function (PUF). These D flip-flops are hardware components which present a random start-up value when powered up. We show that against all odds, enough randomness exists in such elements when implemented on an Application-Specific Integrated Circuit (ASIC) to turn the responses of a number of D flip-flops into a secret random sequence allowing to derive keys for use in conjunction with cryptographic algorithms. In addition to being unpredictable, these flip-flops have the advantage that they can be spread over random locations in an ASIC. This makes them very difficult to reverse-engineer when used to hide a secret key in a design at a relatively small cost in resources.
Evaluation of Vibrant® Soundbridge™ positioning and results with laser doppler vibrometry and the finite element model (2021)

The etiology of hearing loss originates from genetic factors and includes several other events including infections, working or living environment, as well as several endocrine and metabolic disorders. The Vibrant<sup>®</sup> Soundbridge<sup>™</sup> (VSB) is an implantable hearing aid whose floating mass transducer (FMT) is attached to the long process of the incus. The device is used for pure sensorineural hearing loss with an intact middle ear. Variations in the manner of attachment may occur. Knowledge of the impact of such variations on the overall device performance may guide towards optimal transducer attachment during surgery. A mechanical modelling of the ear was first reported by von Békésy and indicated that the tympanic membrane (TM) moves as a stiff plate, and that the mallear and incudal ligaments act as a rotation axis for the ossicular chain at low frequencies. Experimental investigations and simulations with the model yield the same main results. The first fitting situation, where the FMT floats freely in the middle ear, provides by far the worst possible results. Contact to the stapes supra-structure of the FMT is necessary for optimal performance of the FMT. The mastoid specimen preserves its acoustic properties that have been shown to be similar to those in the vital human ear, under these conditions. Properly coupling the electromagnetic transducer to the ossicles can be difficult and it requires a certain degree of experience. A finite-element model (FEM) is useful for functional evaluation of the VSB since it enables easy modelling of the complicated middle ear structures and simulation of their dynamic behavior which makes it easy to understand it in detail without experiments.
Rescue of HIV-1 Receptor Function through Cooperation between Different Forms of the CCR5 Chemokine Receptor (2002)

Interaction of the human immunodeficiency virus (HIV-1) envelope glycoproteins with the CCR5 chemokine receptor, a G-protein-coupled receptor, triggers a membrane fusion process and virus entry. Cooperation for HIV-1 receptor activity was observed when two forms of CCR5 were coexpressed, either the wild-type (WT) receptor and a defective mutant with deletion of the amino-terminal (NT) extracellular domain or the latter deltaNT mutant and a human-mouse CCR5 chimera bearing the NT domain from human CCR5. Cooperation was most efficient when the two forms of CCR5 were in a 1:1 ratio. It was not observed between the CCR5 deltaNT mutant and a chimeric receptor (5444) in which the NT domain of CCR5 was in the context of another G-protein-coupled receptor, the HIV-1 receptor CXCR4. These results suggested that physical association between two forms of CCR5 was required for their cooperation. Coimmunoprecipitation experiments in transfected cell lysates indeed showed that the deltaNT CCR5 mutant formed oligomeric complexes with the WT CCR5 or the HMMM chimera but not with the CXCR4-derived chimera 5444. These observations suggest that the formation of CCR5 oligomers is a constitutive process independent from activation by chemokine ligands. The interaction of HIV-1 with independent subunits of CCR5 oligomers could favor the local recruitment of fusiogenic proteins and the formation of a fusion pore.
Hybrid Bonding Interconnect for Advanced Heterogeneously Integrated Processors (2021)

Die stacking enables significant performance leaps in computing capability and memory/processor integration. Conventional die stacking uses solder interconnects which suffer from several scaling limitations. A new die to die interconnect technology, hybrid bonding, removes many of these limitations and allows several order of magnitude improvements in die-to-die connection density. In this paper, we provide an overview of hybrid bonding technology and its capabilities in the context of high-performance computing applications. The basic process & benefits of hybrid bonding vs. conventional solder interconnect are discussed. The signal integrity and power reduction benefits of hybrid bonding for several types of die-to-die interconnects are shown. We demonstrate that hybrid bonding can decrease the interconnect parasitics & correspondingly reduce the interconnect power by more than 5X. The design, manufacturing & assembly steps of our test chips and some of the fabrication results are also discussed.
High moisture extrusion processing of hemp protein ingredients as influenced by their composition and physicochemical properties (2023)

The aim of this study was to investigate the influence of the nutrient composition, protein profile and physicochemical properties of two commercial hemp protein ingredients, i.e., a hemp protein isolate (HPI) and a hemp protein concentrate (HPC) obtained by wet extraction and oil pressing, respectively, on their processability under high moisture extrusion (HME) conditions. The hemp protein ingredients were processed both individually and in combination with commercial soy (SPC) and pea (PPC) protein concentrates.HPC displayed the highest concentration of cysteine (1.6 g/100 g protein) and free thiols (15 nmol/mg protein) among the ingredients investigated, while UPLC-MS/MS analysis highlighted a higher relative concentration of 11S globulin (edestin) in HPI than HPC.The hemp protein ingredients displayed low solubility in water across the pH range 3–8 (5–9%) and their hydration capacity was closer to that of wheat gluten than SPC and PPC.HME trials were performed using a bench scale twin-screw extruder. HPI was not processable regardless of the conditions tested, which could be explained by the high concentration of edestin macromolecular complexes which hindered the formation of the desired fibrous texture. Conversely, HPC provided extrudates with promising textural properties both when processed individually and in combination with SPC or PPC. The peak force required to cut the extrudates throughout their entire thickness, as determined using a texture analyzer equipped with a light knife blade probe guillotine, increased with an increase in the relative concentration of HPC for blends with either SPC or PPC, that is with an increase in the relative importance of covalent bonds in fibrous structure formation.The outcomes of this study should be confirmed at larger scale to assess the potential of the derived extrudates to be used for the development of meat and fish analogues.
Increased production of intestinal immunoglobulins in Syntenin-1-deficient mice (2014)

Syntenin-1 is an intracellular PDZ protein that binds multiple proteins and regulates protein trafficking, cancer metastasis, exosome production, synaptic formation, and IL-5 signaling. However, the functions of Syntenin-1 have not yet been clearly characterized in detail, especially in vivo. In this study, we generated a Syntenin-1 knock out (KO) mouse strain and analyzed the role(s) of Syntenin-1 in IL-5 signaling, because the direct interaction of Syntenin-1 with the cytoplasmic domain of the IL-5 receptor α subunit and the regulation of IL-5 signaling by Syntenin-1 have been reported. Unexpectedly, the number of IL-5-responding cells was normal and the levels of fecal immunoglobulins were rather higher in the Syntenin-1 KO mice. We also found that IgA and IgM production of splenic B cells stimulated in vitro was increased in Syntenin-1 KO mice. In addition, we showed that a distribution of intestinal microbial flora was influenced in Syntenin-1 KO mice. Our data indicate that Syntenin-1 negatively regulates the intestinal immunoglobulin production and has a function to maintain the intestinal homeostasis in vivo. The analysis of Syntenin-1 KO mice may provide novel information on not only mucosal immunity but also other functions of Syntenin-1 such as cancer metastasis and neural development.