gebhart/patrepeval huggingface dataset:
PULMONARY REGURGITATION WITH VENTRICULAR SEPTAL DEFECT AND PULMONIC STENOSIS—TETRALOGY OF FALLOT VARIANT (1969)

PULMONARY REGURGITATION WITH VENTRICULAR SEPTAL DEFECT AND PULMONIC STENOSIS—TETRALOGY OF FALLOT VARIANTROBERT E. DURNIN, M.D., RICHARD WILLNER, M.D., SHYAMA VIRMANI, M.D., TSUN-YEE LAWRENCE, M.D. and DONALD C. FYLER, M.D.Audio Available | Share
Molecular Dynamics of Polyfarnesene (2018)

This paper represents the first comprehensive report of the molecular weight dependence of the dynamics of polyfarnesene (PF), utilizing oscillatory shear rheology and broadband dielectric spectroscopy. Extended PF chain conformations arising from tightly packed C11/C13 pendant groups reduce the probability of chain entanglements and lead to Rouse-like melt dynamics up to a critical molecular weight ∼105 g/mol. At higher molecular weights, PF behaves as an entangled polymer melt. Dielectric spectroscopy measurements establish PF as a type-A polymer, whose normal mode relaxation is strongly dependent on molecular weight, providing a compliment to melt rheology for the exploration of PF global chain dynamics.
Philosophy, Rights and Natural Law (2019)

A celebratory collection of essays on philosophy, rights and natural law, inspired by the work of Knud Haakonssen Over his long and illustrious career, Knud Haakonssen has explored the role of natural law in formulating doctrines of obligation and rights in accordance with the interests of early modern polities and churches. A hallmark of his approach has been to show how natural law in early modern Europe was not a unified doctrine, but a field of crosscutting idioms that prosecuted competing political and juridical programmes. The essays collected in this volume range across this exciting and contested field. These studies acknowledge Haakonssen's immense academic achievement and give us new insights into the cultural and political role of law and rights in a variety of historical contexts and circumstances. Key Features Crosses national, disciplinary, intellectual and ideological borders Deals with a wide range of contexts and aspects over a chronological period from the Reformation to the aftermath of the French Revolution Covers an unusually wide range of questions at the intersection between natural law, religion and politics Contributors include Maria Rosa Antognazza, James Harris, Simone Zurbuchen and John Cairns "
AsthmaGuru (2013)

Asthma is a widespread chronic disease. Poor management of Asthma results in a large number of hospitalizations each year, the majority of which are avoidable through strict adherence to medication. AsthmaGuru is a system which aims to provide personalized guidance to users on their health state, with an aim to improve their compliance to medication. To achieve this aim, AsthmaGuru aggregates three forms of data: (a) automated and unobtrusive measurement of medication adherence using a low-power portable electronic attachment to an inhaler, (b) lung function measurement based on portable spirometry and (c) local air quality metrics. We leverage a custom low-power hardware platform for augmenting the inhalers and spirometry and develop a custom Android API for delay-tolerant data collection.
Faculty Opinions recommendation of Structural basis for gating pore current in periodic paralysis. (2018)

Potassium-sensitive Hypokalemic and Normokalemic Periodic Paralysis (HypoPP, NormoPP) are inherited skeletal muscle diseases characterized by episodes of flaccid muscle weakness 1,2 .They are caused by mutations in one gating charge in an S4 transmembrane segment in the voltage sensor (VS) of voltage-gated sodium channel Na v 1.4 or calcium channel Ca v 1.1 1,2 .Mutations of the outermost arginine gating charges (R1 and R2) cause HypoPP 1,2 by creating a pathogenic gating pore in the VS through which cations leak in the resting state 3,4 .Mutations of the third arginine gating charge (R3) cause NormoPP 5 owing to cationic leak in activated/inactivated states 6 .Here we present high-resolution structures of these pathogenic gating pores in the model bacterial sodium channel Na V Ab 7,8 .Mutation of R2 in Na V Ab gives gating pore current in resting states, whereas mutation of R3 gives gating pore current in activated/inactivated states.Mutations R2G and R3G have no effect on backbone structures of VS, but create aqueous space near the hydrophobic constriction site (HCS) that controls gating charge movement through VS.The R3G mutation extends the extracellular aqueous cleft completely through the activated VS.Although the R2G mutation does not create a continuous aqueous pathway in the activated state, molecular modeling of the resting state reveals a complete water-accessible pathway.Crystal structures of Na V Ab/R2G in complex with guanidinium define a potential drug target site.Molecular dynamics simulations illustrate the mechanism of Na + permeation through the mutant gating pore in concert with conformational fluctuations of gating charge R4.Our results reveal pathogenic mechanisms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research,
Adaptive Fuzzy Prediction for Automotive Applications Usage (2015)

Modern automobiles are increasingly complicated machines with an ever-increasing number of features. Understanding how these features work, when to use them, and in general how to make the best use of your vehicle is not a simple task. This research presents an evolving fuzzy system that personalizes the fuzzy membership functions based on individual driving habits. The system was successfully applied to estimate the likelihood of a driver using cruise control based on past usage preferences, current context, and recent driving history. Experimental results show that the proposed fuzzy system can learn the membership functions adaptively according to the driving behavior, and predicts the cruise control usage with high confidence.
New applications of near-field optical storage (1995)

Some time ago, we described a new type of near-field imaging system using the Solid Immersion Lens . A confocal microscope using this principle has demonstrated sub-100 nm resolution with visible light. In this paper, we will describe how this device is being applied to increasing the density of optical storage in CD ROMs and magneto-optical storage systems. The SIL is placed between the objective and the disk. As illustrated in Fig. 1(a), if the SIL is in the form of a hemisphere, rays enter it along its radii and converge at its center. If the refractive index of the SIL is n , the wavelength in this material is reduced by 1/ n and consequently increases the effective NA of the objective lens by the refractive index n and decreases the spot size by 1/ n . With this configuration, we were able to obtain good quality images of a grating with 100 nm gaps and strip widths.
Luminescence quenching in epitaxially grown PCN-224 type metal-organic frameworks (2022)

Core-shell and multivariant metal-organic frameworks (MOFs) of the PCN-224 type were prepared using metal-free and metalated porphyrin building blocks. Probing these MOFs with luminescence quenching upon exposure to oxygen reveals efficient gas transport and oxygen quenching in the core of the MOF. Undesirable energy transfer results in diminished contribution of the phosphorescence component in all mixed MOFs except for the physical mixture of individual crystals used as a reference.
Isolation and structure of pro-methionine-enkephalin: Potential enkephalin precursor from porcine hypothalamus (1979)

A hexapeptide that we have named pro-methionine-enkephalin has been isolated from acid extracts of porcine hypothalami and found to have the amino acid sequence H-Tyr-Gly-Gly-Phe-Met(O)-Arg-OH. This peptide is not a fragment of either porcine beta-lipotropin or beta-endorphin, which suggests that it could be a precursor of [Met]enkephalin in the brain by a pathway differing from the one usually postulated. The existence of still larger precursors of [Met]enkephalin, perhaps related to the recently reported alpha-neo-endorphin, is strongly implied by these studies. Synthetic H-Tyr-Gly-Gly-Phe-Met-Arg-OH exhibited low, but significant, opiate activity in vitro.
Enantioselective Nickel-Catalyzed Mizoroki–Heck Cyclizations To Generate Quaternary Stereocenters (2017)

The development of enantioselective carbon-carbon bond couplings catalyzed by nonprecious metals is highly desirable in terms of cost efficiency and sustainability. The first nickel-catalyzed enantioselective Mizoroki-Heck coupling is reported. This transformation is accomplished via mild reaction conditions, leveraging on QuinoxP* as a chiral ligand to afford oxindoles containing quaternary stereocenters. Good reactivity and selectivity are observed in the presence of various functional groups. Computational studies suggest that the oxidative addition assembles an atropisomeric intermediate responsible for the facial selectivity of the insertion step.
Optical transmitter with 1060 nm VCSEL for low power interconnect (2011)

An optical transmitter composed of a 90-nm CMOS driver and a high efficiency 1060nm VCSEL is characterized. The 10Gb Ethernet eye mask specification is met with a +33% margin with 1.7 mW/Gbps power consumption.
Designing new materials and processes for directed self-assembly applications (2012)

Directed self-assembly (DSA) of block copolymers (BCPs) is a promising technology for advanced patterning at future technology nodes, but significant hurdles remain for commercial implementation. The most widely studied material for DSA is poly(styrene-<i>block</i>-methyl methacrylate) (PS-PMMA), but this material has a relatively weak segregation strength that has limited its utility to patterns above 24 nm pitch. This paper reports on some of Dow's efforts to develop new materials capable of extending DSA to smaller pitch by development of new BCP copolymer materials with stronger segregation strength. Some preliminary efforts are reported on new substrate treatments that stabilize perpendicular orientations in a high-&chi; block copolymer that also incorporate an etch-resistant block to facilitate patterning at small dimensions. In addition, development of new block copolymer materials that have a &chi;-parameter that is large enough to drive defect reduction and but not so high that it precludes thermal annealing are also presented. DSA of these new materials is demonstrated using thermal annealing processes at pitch ranging from 40 to 16 nm, and etch capability is also demonstrated on a material with 18 nm pitch. These technologies hold promise for the extension of DSA to sub 24 nm pitch.
Data from Expansion of Tumor-Infiltrating CD8<sup>+</sup> T cells Expressing PD-1 Improves the Efficacy of Adoptive T-cell Therapy (2023)

&lt;div&gt;Abstract&lt;p&gt;Recent studies have found that tumor-infiltrating lymphocytes (TIL) expressing PD-1 can recognize autologous tumor cells, suggesting that cells derived from PD-1&lt;sup&gt;+&lt;/sup&gt; TILs can be used in adoptive T-cell therapy (ACT). However, no study thus far has evaluated the antitumor activity of PD-1–selected TILs &lt;i&gt;in vivo&lt;/i&gt;. In two mouse models of solid tumors, we show that PD-1 allows identification and isolation of tumor-specific TILs without previous knowledge of their antigen specificities. Importantly, despite the high proportion of tumor-reactive T cells present in bulk CD8 TILs before expansion, only T-cell products derived from sorted PD-1&lt;sup&gt;+&lt;/sup&gt;, but not from PD-1&lt;sup&gt;−&lt;/sup&gt; or bulk CD8 TILs, specifically recognized tumor cells. The fold expansion of PD-1&lt;sup&gt;+&lt;/sup&gt; CD8 TILs was 10 times lower than that of PD-1&lt;sup&gt;−&lt;/sup&gt; cells, suggesting that outgrowth of PD-1&lt;sup&gt;−&lt;/sup&gt; cells was the limiting factor in the tumor specificity of cells derived from bulk CD8 TILs. The highly differentiated state of PD-1&lt;sup&gt;+&lt;/sup&gt; cells was likely the main cause hampering &lt;i&gt;ex vivo&lt;/i&gt; expansion of this subset. Moreover, PD-1 precisely identified marrow-infiltrating, myeloma-specific T cells in a mouse model of multiple myeloma. &lt;i&gt;In vivo&lt;/i&gt;, only cells expanded from PD-1&lt;sup&gt;+&lt;/sup&gt; CD8 TILs contained tumor progression, and their efficacy was enhanced by PDL-1 blockade. Overall, our data provide a rationale for the use of PD-1–selected TILs in ACT. &lt;i&gt;Cancer Res; 77(13); 3672–84. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
A random matrix approach to detect defects in a strongly scattering polycrystal: How the memory effect can help overcome multiple scattering (2014)

We report on ultrasonic imaging in a random heterogeneous medium. The goal is to detect flaws embedded deeply into a polycrystalline material. A 64-element array of piezoelectric transmitters/receivers at a central frequency of 5 MHz is used to capture the Green's matrix in a backscattering configuration. Because of multiple scattering, conventional imaging completely fails to detect the deepest flaws. We utilize a random matrix approach, taking advantage of the deterministic coherence of the backscattered wave-field which is characteristic of single scattering and related to the memory effect. This allows us to separate single and multiple scattering contributions. As a consequence, we show that flaws are detected beyond the conventional limit, as if multiple scattering had been overcome.
Numerical calculation of relaxation rates in amorphous silicon (1999)

Relaxation rates for strong and weak perturbations of the vibrational spectrum in amorphous silicon have been calculated using molecular dynamics simulations. A strong perturbation produced by creating a nonequilibrium normal mode distribution was found to relax on a 100 ps time scale. A weak perturbation generated by exciting a small number of modes in an equilibrated system yielded vibrational lifetimes on the order of 10 ps. Thermalization following the insertion of a heat pulse into the center of the simulation supercell also occurred on a 10 ps time scale.
Open Wireless Software Radio on Common PC (2006)

Software radio is the promising technology that allows the different wireless standards easily be converged. Using general purpose processors and open-source operating systems instead of dedicated hardware and software to build the wireless communication system is very flexible and low-cost. In this article,the open-source platform based on common PCs is described, which allows rapid development and verification of software radio systems. We also discuss the efficient distributed strategies essential for this platform. Finally, the demonstration system of TD-SCDMA is developed and the conclusion given
High Torque Density Macro-scale Electrostatic Rotating Machines: Electrical Design, Generalized <inline-formula> <tex-math notation="LaTeX">$d-q$</tex-math> </inline-formula> Framework, and Demonstration (2018)

The use of advanced dielectric liquids and manufacturing techniques for enhanced surface area per unit volume, along with other multiplicative gains, is enabling macro-scale electrostatic machines with competitive torque densities. This emergence prompts the need for circuit modeling-that guides machine design and drive controls-rooted in the canon of well-established electromagnetic machinery practices. In this study, prior dielectric and manufacturing innovations are combined with a newly developed unified electrostatic machine d-q-axis framework to form a machine that demonstrates industrial utility. Design, equivalent circuits, and performance are validated by an experimental prototype intended for low-speed direct-drive servo actuators. A prototype electrostatic machine was constructed entirely of aluminum and printed circuit boards, and possesses active material torque densities ≥1.4 N·m/kg and ≥2.65 N·m/L without the need for forced air or liquid cooling. Additional features include near zero loss at stall and low torque ripple.
Response to Ethanol Reduced by Past Thiamine Deficiency (1985)

Ethanol-induced intoxication and hypothermia were studied in rats approximately 7 months after severe thiamine deficiency, when treated rats appeared to have recovered their physical health. Previously induced thiamine deficiency without prior ethanol exposure significantly decreased the area under the curve plotted for the concentration of ethanol in blood and also decreased behavioral impairment and hypothermia due to ethanol exposure. Pathophysiologic changes resulting from thiamine deficiency may contribute to both the pharmacodynamic and pharmacokinetic tolerance to ethanol in chronic alcoholics.
Disparate impacts on online information access during the Covid-19 pandemic (2022)

The COVID-19 pandemic has stimulated important changes in online information access as digital engagement became necessary to meet the demand for health, economic, and educational resources. Our analysis of 55 billion everyday web search interactions during the pandemic across 25,150 US ZIP codes reveals that the extent to which different communities of internet users enlist digital resources varies based on socioeconomic and environmental factors. For example, we find that ZIP codes with lower income intensified their access to health information to a smaller extent than ZIP codes with higher income. We show that ZIP codes with higher proportions of Black or Hispanic residents intensified their access to unemployment resources to a greater extent, while revealing patterns of unemployment site visits unseen by the claims data. Such differences frame important questions on the relationship between differential information search behaviors and the downstream real-world implications on more and less advantaged populations.
A benchmark for evaluation of algorithms for identification of cellular correlates of clinical outcomes (2015)

The Flow Cytometry: Critical Assessment of Population Identification Methods (FlowCAP) challenges were established to compare the performance of computational methods for identifying cell populations in multidimensional flow cytometry data. Here we report the results of FlowCAP-IV where algorithms from seven different research groups predicted the time to progression to AIDS among a cohort of 384 HIV+ subjects, using antigen-stimulated peripheral blood mononuclear cell (PBMC) samples analyzed with a 14-color staining panel. Two approaches (FlowReMi.1 and flowDensity-flowType-RchyOptimyx) provided statistically significant predictive value in the blinded test set. Manual validation of submitted results indicated that unbiased analysis of single cell phenotypes could reveal unexpected cell types that correlated with outcomes of interest in high dimensional flow cytometry datasets.
Careful observation is the first thing to do in science (2014)

Journal Article Careful observation is the first thing to do in science Get access Sumio Iijima Sumio Iijima Graduate School of Science and Technology, Meijo University, National Institute of Advanced Industrial Science and Technology/Nanotube Research Center, and NEC Search for other works by this author on: Oxford Academic PubMed Google Scholar Microscopy, Volume 63, Issue suppl_1, November 2014, Page i1, https://doi.org/10.1093/jmicro/dfu097 Published: 01 November 2014
High-throughput cooperative transmissions using adaptive complex-field network coding (2010)

Network Coding over wireless networks can provide considerable throughput increase with respect to traditional cooperative relaying strategies at no loss of diversity gain. In this paper, a novel cooperation protocol is developed based on adaptive complex-field wireless network coding. Sources transmit new information symbols linearly combined with symbols previously-estimated from other sources, and weighted using a link adaptive power scaling coefficient. Different from existing wireless network coding protocols, transmissions are not restricted to binary symbols, do not need to be simultaneous, and allow for errors when estimating symbols transmitted from other sources. In a network with N sources, the developed protocol can achieve a throughput up to approximately 1=N symbols per source per channel use, as well as a diversity order of N. Simulated results corroborate the performance analysis of the protocol, showing gains with respect to traditional multi-source cooperation protocols.
Evaluation of Histone Deacetylases as Drug Targets in Huntington’s Disease modelsStudy of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model. (2010)

The family of histone deacetylases (HDACs) has recently emerged as important drug targets for treatment of slow progressive neurodegenerative disorders, including Huntington's disease (HD). Broad pharmaceutical inhibition of HDACs has shown neuroprotective effects in various HD models. Here we examined the susceptibility of HDAC targets for drug treatment in affected brain areas during HD progression. We observed increased HDAC1 and decreased HDAC4, 5 and 6 levels, correlating with disease progression, in cortices and striata of HD R6/2 mice. However, there were no significant changes in HDAC protein levels, assessed in an age-dependent manner, in HD knock-in CAG140 mice and we did not observe significant changes in HDAC1 levels in human HD brains. We further assessed acetylation levels of α-tubulin, as a biomarker of HDAC6 activity, and found it unchanged in cortices from R6/2, knock-in, and human subjects at all disease stages. Inhibition of deacetylase activities was identical in cortical extracts from R6/2 and wild-type mice treated with a class II-selective HDAC inhibitor. Lastly, treatment with class I- and II-selective HDAC inhibitors showed similar responses in HD and wild-type rat striatal cells. In conclusion, our results show that class I and class II HDAC targets are present and accessible for chronic drug treatment during HD progression and provide impetus for therapeutic development of brain-permeable class- or isoform-selective inhibitors.
Real time collaborative intelligent solutions (2005)

In this paper, we share our experience of the real-time aspects of collaborative intelligent systems. We discuss the representation of application domain knowledge using a job description language (JDL) and FIPA specification. We also present the architecture of the intelligent agents that enables the integration of knowledge and system capabilities. Finally, we describe aspects of collaborative systems relative to system scalability and validation through simulation.
Virtual Coupling Schemes for Causality Control in Networked Haptic Environments (2006)

In networked haptic environments, multiple users remotely collaborate sharing the same virtual space; such environments are used in surgical simulation training, maintenance, and task-training, among other applications. It is vital to maintain causality of events in them, and thus achieve consistency in collaboration. This is especially true in the presence of time delays between the users. Usually, client-server architecture is widely used to control this problem in networked haptic environments. This method introduces a round-trip delay for each user and relies on the ability of the client to maintain communication with the server. In contrast, peer-to-peer architecture allows time delay to be reduced to half compared to client-server based methods by multicasting the information from each user to all the others. It presents, however, the greatest difficulties to control causality between the users. This paper presents two virtual coupling schemes to control causality in a peer-to-peer architecture. The performance of the schemes for constant time delays were compared to server based method. The experimental results obtained demonstrate that one of the virtual coupling schemes has a comparable performance to server-based method. Therefore, this scheme allows multiple users to collaborate without relying on a sever and, at the same time, maintaining causality among them.