gebhart/patrepeval huggingface dataset:
Supplementary Table 1 from Complement Factor H Is Elevated in Bronchoalveolar Lavage Fluid and Sputum from Patients with Lung Cancer (2023)

Supplementary Table 1 from Complement Factor H Is Elevated in Bronchoalveolar Lavage Fluid and Sputum from Patients with Lung Cancer
Effects of graphite addition and sintering temperature on strength and toughness of sintered compacts made from Cr-Mn containing steel powder. (1993)

Effects of graphite addition and sintering temperature on tensile strength of sintered compacts made from 1%Cr-0.7%Mn-0.3%Mo steel powder have been investigated.A sintered compact with 0.9% graphite addition gives the maximum strength of 760MPa at the process condition of compacting pressure of 690MPa and sintering temperature of 1523K. The major factors controlling tensile strength of 1%Cr-0.7%Mn-0.3%Mo sintered compact have been proved to be sintered density, contents of carbon and MnO⋅Cr2O3 spinet inclusions and amount of cementite precipitated in grain boundaries.The decrease of tensile strength of the sintered compact with 1.2% graphite addition is caused by precipitation of cementite in grain boundaries. The tensile strength lowers with the increase of sintering temperature from 1423K to 1473K because of the decrease of carbon content. The tensile strength increases with the increase of sintering temperature from 1473K to 1523K because of the reduction of MnO⋅Cr2O3 spinel oxide.
Abstract 255: Low Endothelial Shear Stress (ESS) is Responsible for the Heterogeneity and Severity of Coronary Atherosclerotic Plaques: An In-Vivo IVUS Natural History Study (2006)

Objectives: Atherosclerotic lesions are multifocal and progress at different rates, despite exposure to the same systemic risk factors. We investigated the potential role of focal areas of low ESS on the localization and severity of plaque formation. Methods: Twenty seven streptozotocin-induced diabetic hyperlipidemic swine were studied. Serial IVUS with 3D reconstruction of each coronary artery was performed at 4, 8, 23 and 30 wks. Plaque severity by IVUS was defined by plaque thickness (0.4 – 0.7 mm vs 0.8 –1.0 mm vs >1.0 mm). Local ESS throughout each artery was determined from computational fluid dynamics. Plaque-free subsegments by IVUS (average length 5 mm) with low ( 2.4 Pa) ESS were identified in each artery at 23 wks; and assessed by histology at 30 wks. Plaque severity by histology was defined by intimal/media ratio and maximum intimal thickness. Results: Plaque developed and progressed after 8 weeks, with remarkable heterogeneity of number and severity of plaque by IVUS over time (Fig A). Histology indicated that subsegments (n=43, average=4.2 per artery) with low ESS at baseline were associated with significantly higher intima/media ratio and maximum intimal thickness at follow-up compared to areas with moderate or high ESS (p Conclusions: Low ESS determines the location and severity of coronary artery plaque. The heterogeneity of the natural history of atherosclerotic plaques is related to the local ESS environment. Ongoing analyses focus on the role of local ESS on vascular remodeling, plaque inflammation and neovascularization over time.
Stellate ganglion block and cardiac sympathetic denervation in patients with inappropriate sinus tachycardia (2019)

SG blockade modestly reduces resting HR but has no significant effect on HR during exercise. Permanent CSD may have a modest role in alleviating symptoms in selected patients with IST.
Micronutriments. Les risques/bénéfices, bases de la règlementation (2017)

Toute mise sur le marché d’un aliment relève d’un encadrement réglementaire reposant sur des principes stricts de sécurité des produits, de non-tromperie du consommateur et de concurrence loyale entre opérateurs économiques. Les aliments vecteurs de micronutriments ne dérogent pas à la règle.
Pulmonary Vascular Stiffness: Measurement, Modeling, and Implications in Normal and Hypertensive Pulmonary Circulations (2011)

This article introduces the concept of pulmonary vascular stiffness, discusses its increasingly recognized importance as a diagnostic marker in the evaluation of pulmonary vascular disease, and describes methods to measure and model it clinically, experimentally, and computationally. It begins with a description of systems-level methods to evaluate pulmonary vascular compliance and recent clinical efforts in applying such techniques to better predict patient outcomes in pulmonary arterial hypertension. It then progresses from the systems-level to the local level, discusses proposed methods by which upstream pulmonary vessels increase in stiffness, introduces concepts around vascular mechanics, and concludes by describing recent work incorporating advanced numerical methods to more thoroughly evaluate changes in local mechanical properties of pulmonary arteries.
Farmland practices are driving bird population decline across Europe (2023)

Declines in European bird populations are reported for decades but the direct effect of major anthropogenic pressures on such declines remains unquantified. Causal relationships between pressures and bird population responses are difficult to identify as pressures interact at different spatial scales and responses vary among species. Here, we uncover direct relationships between population time-series of 170 common bird species, monitored at more than 20,000 sites in 28 European countries, over 37 y, and four widespread anthropogenic pressures: agricultural intensification, change in forest cover, urbanisation and temperature change over the last decades. We quantify the influence of each pressure on population time-series and its importance relative to other pressures, and we identify traits of most affected species. We find that agricultural intensification, in particular pesticides and fertiliser use, is the main pressure for most bird population declines, especially for invertebrate feeders. Responses to changes in forest cover, urbanisation and temperature are more species-specific. Specifically, forest cover is associated with a positive effect and growing urbanisation with a negative effect on population dynamics, while temperature change has an effect on the dynamics of a large number of bird populations, the magnitude and direction of which depend on species' thermal preferences. Our results not only confirm the pervasive and strong effects of anthropogenic pressures on common breeding birds, but quantify the relative strength of these effects stressing the urgent need for transformative changes in the way of inhabiting the world in European countries, if bird populations shall have a chance of recovering.
Development of Dual and Selective Degraders of Cyclin‐Dependent Kinases 4 and 6 (2019)

Cyclin-dependent kinases 4 and 6 (CDK4/6) are key regulators of the cell cycle, and there are FDA-approved CDK4/6 inhibitors for treating patients with metastatic breast cancer. However, due to conservation of their ATP-binding sites, development of selective agents has remained elusive. Here, we report imide-based degrader molecules capable of degrading both CDK4/6, or selectively degrading either CDK4 or CDK6. We were also able to tune the activity of these molecules against Ikaros (IKZF1) and Aiolos (IKZF3), which are well-established targets of imide-based degraders. We found that in mantle cell lymphoma cell lines, combined IKZF1/3 degradation with dual CDK4/6 degradation produced enhanced anti-proliferative effects compared to CDK4/6 inhibition, CDK4/6 degradation, or IKZF1/3 degradation. In summary, we report here the first compounds capable of inducing selective degradation of CDK4 and CDK6 as tools to pharmacologically dissect their distinct biological functions.
High-Resolution Definition of Vaccine-Elicited B Cell Responses Against the HIV Primary Receptor Binding Site (2012)

The high overall genetic homology between humans and rhesus macaques, coupled with the phenotypic conservation of lymphocyte populations, highlights the potential use of nonhuman primates (NHPs) for the preclinical evaluation of vaccine candidates. For HIV-1, experimental models are needed to identify vaccine regimens capable of eliciting desired immune responses, such as broadly neutralizing antibodies (bNAbs). One important neutralization target on the HIV-1 envelope glycoproteins (Envs) is the conserved primary CD4 receptor binding site (CD4bs). The isolation and characterization of CD4bs-specific neutralizing monoclonal Abs (mAbs) from HIV-1-infected individuals have provided insights into how broadly reactive Abs target this conserved epitope. In contrast, and for reasons that are not understood, current Env immunogens elicit CD4bs-directed Abs with limited neutralization breadth. To facilitate the use of the NHP model to address this and other questions relevant to human humoral immunity, we defined features of the rhesus macaque immunoglobulin (Ig) loci and compared these to the human Ig loci. We then studied Env-immunized rhesus macaques, identified single B cells expressing CD4bs-specific Abs, and sequenced and expressed a panel of functional mAbs. Comparison of vaccine-elicited mAbs with HIV-1 infection-induced mAbs revealed differences in the degree of somatic hypermutation of the Abs as well as in the fine specificities targeted within the CD4bs. These data support the use of the preclinical NHP model to characterize vaccine-induced B cell responses at high resolution.
387-nm Generation in GdxY1-xCa4O(BO3)3Crystal and Its Utilization for 193-nm Light Source (2003)

We report on near-UV generation in GdxY1-xCa4O(BO3)3 crystals used under type-I non-critical phase-matching conditions. GdxY1-xCa4O(BO3)3 was also applied to a 193-nm deep-UV laser source based on the eighth harmonic of an erbium-doped fiber amplifier output at 1547 nm, in which GdxY1-xCa4O(BO3)3 (x = 0.68) was used for 387-nm generation. Using this compact light source, 5% conversion efficiency from the 1547-nm input to the 193-nm output was achieved at a fundamental peak power of 18 kW.
Optical higher-order symbolic recognition (1990)

Several new higher-order spatial symbol recognition methods for optical symbolic substitution-based calculations are presented. In the case of logic processing, higher-order symbolic substitution (SS) rules can implement multivariable logic functions. For binary arithmetic calculations requiring carry propagation by simultaneously processing a number of bits, the computational speed increases. Finally, in image processing, the higher-order SS rules allow the use of larger local windows. For a higher-order spatial symbol recognition, both multiplicative and additive logic techniques are discussed. Four different higher-order SS recognition optical architectures are suggested: a multireflecting technique using an optical cavity, a lenslet array, an optical phase conjugation, and a content-addressable memory. Either dual-rail or triple-rail optical spatial intensity encoding is employed. Some preliminary experimental results are also presented.
Sequential formation and propagation of caldera ring-faults analysed in analogue experiments (2009)

Abstract: In a series of analogue experiments, we analysed the formation and propagation of caldera ring-faults with the Digital Image Correlation (DIC) method. The results indicate a clear sequence of faulting during subsidence and show the non-uniform propagation direction of individual faults.
Informe sobre el Taller Universidad del Futuro Colombia-Purdue (2015)

El Taller Universidad del Futuro, un evento conjunto de Colombia y Purdue, se llevó a cabo en la Universidad de Purdue en West Lafayette, Indiana, el 28 y 29 de octubre de 2014. Entre sus participantes hubo rectores y consejeros de seis importantes universidades de Colombia, junto con directores ejecutivos de ONG, funcionarios públicos de Estados Unidos y Colombia, y profesores y administradores de Purdue. El taller se centró en el diálogo entre los participantes sobre los programas y áreas de investigación clave que permitirán que las universidades den respuesta a las necesidades del siglo XXI en toda América. Este informe es un resumen del taller y se basa en las contribuciones de todos los participantes. Se sintetizan temas clave como la educación transformadora, las redes de excelencia para la educación y la innovación en colaboración, y los ecosistemas de innovación. Se presentan, además, recomendaciones para acelerar la transformación de las universidades, por ejemplo, el desarrollo de redes de excelencia en áreas clave.
A Curvature Based Shaped Reflector Antenna Design Method for Contoured Beam Synthesis (2022)

A new shaped reflector antenna design technique based on surface curvature for a continental US coverage (CONUS) beam synthesis is presented. An approach based on representing a reflector surface as a set of curves where its shape is modified by altering the curve profile. Instead of directly optimizing the curves, we first evaluate their curvature and represent it using B-spline polynomials. The spline control points are defined as optimization variables, which generates a new curvature profile at each iteration of the optimizer. From the optimized curvature profiles, the reflector surface is generated using an iterative algorithm proposed in this work. The major advantage of this work is that the surface constrains on curvature can be imposed directly in the optimizer, without the need for additional design variables as required in TICRA’s POS software. The validity of this method is confirmed by an application example and its advantages are compared with a reflector surface represented using a traditional technique based on modified Jacobi polynomials.
Impact of Nonlinear Transfer Function and Imperfect Splitting Ratio of MZM on Optical Up-Conversion Employing Double Sideband With Carrier Suppression Modulation (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <?Pub Dtl=""?>Generation of optical millimeter-wave (mm-wave) signal using a Mach–Zehnder modulator (MZM) based on double-sideband (DSB), single-sideband (SSB), and double-sideband with carrier suppression (DSBCS) modulation schemes have been demonstrated for various applications, such as broadband wireless signals or optical up-conversion for wavelength-division-multiplexing (WDM) radio-over-fiber (RoF) network, wideband surveillance, spread spectrum, and software-defined radio. Among these schemes, DSBCS modulation offers the best receiver sensitivity, lowest spectral occupancy, the least stringent requirement of electrical bandwidth, and the smallest receiving power penalty after long transmission distance. Nonetheless, the inherent nonlinear E/O (electrical/optical) conversion response of a MZM is such that the signal quality of the optical mm-wave suffers. Fabrication tolerances make a balanced 50/50 splitting ratio of the MZM's y-splitter particularly difficult to achieve. As a result, imbalanced MZMs have a finite extinction ratio (ER) and degrade the optical carrier suppression ratio (OCSR) using DSBCS modulation. In this paper, the effect of the MZM nonlinearity and imbalanced y-splitter on optical mm-wave generation by DSBCS modulation is theoretically and experimentally investigated. A novel approach with better performance and greater cost-effectiveness than dual-electrode MZM (DD-MZM) is presented to realize a DSBCS modulation scheme based on a single-electrode MZM (SD-MZM). </para>
Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice (2013)

These results indicate that DEP-1 acts as an endogenous antagonist of the insulin receptor, and downregulation of DEP-1 results in an improvement of insulin sensitivity. DEP-1 may therefore represent a novel target for attenuation of metabolic diseases.
6G Networks: Beyond Shannon Towards Semantic and Goal-Oriented\n Communications (2020)

The goal of this paper is to promote the idea that including semantic and\ngoal-oriented aspects in future 6G networks can produce a significant leap\nforward in terms of system effectiveness and sustainability. Semantic\ncommunication goes beyond the common Shannon paradigm of guaranteeing the\ncorrect reception of each single transmitted packet, irrespective of the\nmeaning conveyed by the packet. The idea is that, whenever communication occurs\nto convey meaning or to accomplish a goal, what really matters is the impact\nthat the correct reception/interpretation of a packet is going to have on the\ngoal accomplishment. Focusing on semantic and goal-oriented aspects, and\npossibly combining them, helps to identify the relevant information, i.e. the\ninformation strictly necessary to recover the meaning intended by the\ntransmitter or to accomplish a goal. Combining knowledge representation and\nreasoning tools with machine learning algorithms paves the way to build\nsemantic learning strategies enabling current machine learning algorithms to\nachieve better interpretation capabilities and contrast adversarial attacks. 6G\nsemantic networks can bring semantic learning mechanisms at the edge of the\nnetwork and, at the same time, semantic learning can help 6G networks to\nimprove their efficiency and sustainability.\n
Oculomotor Tracking Strategy in Normal Subjects with and without Simulated Scotoma (2005)

Subjects with no visual impairment confronted with a central scotoma develop a preferred retinal locus to replace the nonfunctional fovea and appear to suppress normal refoveating saccadic behavior in favor of this location.
The SeaView Secure Database System: A Progress Report. (1990)

Previous studies analyzing acculturation and cardiovascular risk were restricted to individual race/ethnic groups and did not fully account for potential confounders. We examined the independent association between acculturation and hypertension in a contemporary multiethnic sample that included white, black, Latino, and Asian individuals. We examined 51,048 participants in the 2007 California Health Interview Survey who were >18 years, 59.5% of whom were women. The main exposure-of-interest was acculturation score, a summary measure of the additive effect of 4 variables (country of birth, parents' country of birth, language at home, and duration of stay in the United States) ranged from 0 (least acculturation) to 4 (highest acculturation). We found that increased acculturation was associated with hypertension, independent of age, gender, race/ethnicity, education, smoking, alcohol, physical activity, body mass index, and diabetes. Compared with those with the lowest acculturation (score of 0), the multivariable odds ratio (95% confidence interval) of hypertension among those with the highest acculturation (score of 4) was 1.78 (1.50-2.11). This association between acculturation and hypertension was consistent in subgroup analyses by gender, education, smoking, alcohol intake, and body mass index. Increased Western acculturation was found to be positively associated with hypertension in a multiethnic sample, independent of confounders.
Simultaneous lancet-free monitoring of alcohol and glucose from low-volumes of perspired human sweat (2018)

Abstract A lancet-free, label-free biosensor for simultaneous detection of sweat glucose and alcohol was demonstrated using zinc oxide thin films integrated into a nanoporous flexible electrode system. Sensing was achieved from perspired human sweat at low volumes (1–3 μL), comparable to ambient conditions without external stimulation. Zinc oxide thin film electrodes were surface functionalized with alcohol oxidase enzyme and with glucose oxidase enzyme towards developing an affinity biosensor specific to the physiological relevant range of alcohol comprising of 0–2 drinks (0–50 mg/dl) and physiologically relevant range of glucose ranging from hypo- to hyper-glycaemia (50–130 mg/dl) in perspired human sweat. Sensing was achieved by measuring impedance changes associated with alcohol and glucose binding onto the sensor interface using electrochemical impedance spectroscopy with a dynamic range from 0.01–200 mg/dl and a limit of detection of 0.01 mg/dl for alcohol in human sweat. Sensor calibration in synthetic sweat containing interferents (25–200 mg/dl) and comparison using regression and Bland-Altman analysis of sweat sensor performance was done with BACtrack ® . Combinatorial detection of glucose and ethanol in perspired human sweat and comparison of sweat sensor performance with Accu-Chek ® blood glucose monitoring system that we expect would be relevant for pre-diabetics and diabetics for monitoring their glucose levels and alcohol consumption.
Next-gen IGBT module structure for hybrid vehicle with high cooling performance and high temperature operation (2014)

Trends of the Power module for hybrid vehicle are high effective, downsizing, lightweight and higher reliability. To achieve these requirements, IGBT module needs low thermal resistance and high operating temperature. In this paper, we developed new technologies. One technology is the cooling structures which has a direct liquid cooling structure with a solder-joined aluminum heat sink. The module achieves a 30-% volume reduction and a 60-% weight reduction compared to our conventional models. A heat sink with high cooling capacity and a high-strength solder were newly developed to establish the structure. And other is the maximum junction temperature, Tjmax = 175oC continuous operation with automotive required quality. We have applied these new technologies to the next-gen IGBT module for hybrid vehicle application.
Harmonic phase-dispersion microscope with a Mach–Zehnder interferometer (2005)

Harmonic phase-dispersion microscopy (PDM) is a new imaging technique in which contrast is provided by differences in refractive index at two harmonically related wavelengths. We report a new configuration of the harmonic phase-dispersion microscope in a Mach-Zehnder geometry as an instrument for imaging biological samples. Several improvements on the earlier design are demonstrated, including a single-pass configuration and acousto-optic modulators for generating the heterodyne signals without mechanical arm scanning. We demonstrate quantitative phase-dispersion images of test structures and biological samples.
Accelerator structure R&D for linear colliders (2003)

For more than ten years, we have been working on R&D for X-band accelerator structures for the JLC/NLC linear collider. Several types of Detuned (DS) and Damped Detuned Structures (DDS) have been successfully designed and fabricated. They have been experimentally tested at both low power and high power to characterize their mechanical and electrical properties. Recently we started developing a new type of damped detuned structure with optimized round-shaped cavities (RDDS). This paper discusses the special specifications, design methods, fabrication procedures, measurement technologies, and anticipated future improvements for all these structures.
Comparative genomic analysis of 142 bacteriophages infecting Salmonella enterica subsp. enterica (2020)

Based on nucleotide and amino acid sequences, a high diversity was found among Salmonella bacteriophages which validate the use of prophage sequence analysis as a highly discriminatory subtyping tool for Salmonella. Thorough understanding of the conservation and variation of prophage genomic characteristics will facilitate their rational design and use as tools for bacterial strain construction, vector development and as anti-bacterial agents.