gebhart/patrepeval huggingface dataset:
Smoodi: Mood-based music recommendation player (2011)

In this paper, we present a mood-based music recommendation player: Smoodi. The Smoodi provides smart mood recommendation by touch and drag and it has three different views: Mood Square, Cover Flow and Mood Cloud. In the Mood Square, users can check the mood distribution of local clips and generate playlists by touching mood cells. In the Cover Flow, users can find music information and generate similar songs list by dragging a seed song. In the Tag Cloud, users can make playlists by selecting mood tags. For this application, we developed new mood model from collected mood tags and arousal-valence position values and designed a regression function to estimate mood probabilities.
Long-range periodic planar nanostructures produced in glass by femtosecond laser dielectric modification (2005)

Polarization dependent periodic nanostructures consisting of long-range arrayed planes of modification, < 20 nm thick and separated by /spl sim/240 /spl plusmn/ 25 nm, are created in fused silica through femtosecond laser irradiation. The periodicity is revealed by ultrahigh spatial resolution chemical etching combined with atomic force microscopy.
Numerical Investigation of the Pouring Process of Liquid From an Open-Top Hydrostatic Column (2012)

Liquid flows in a particular pattern and sequence when it is poured out from an open-top hydrostatic column. Since the liquid in the pouring process has a large deformation, conventional mesh-based method has difficulty in simulating. A meshless method, the moving particle semi-implicit (MPS) method, has been employed in this paper to calculate the unsteady flow with complex deformation. A modified solid-liquid boundary condition was verified and adopted with a new definition of static liquid layers. The hydrostatic column and the liquid inside were all discretized by identical particles but under different parameter values; the circular arc camber boundary condition is expressed accurately with particles by using cylindrical coordinate system. The pouring process is reproduced numerically and the flowing sequence of fluid is analyzed by tracking the fluid particles. The flowing sequence of the liquid can be calculated by restoring the liquid particles back to their initial positions before it is poured. The mass transfer property, liquid flowing sequence and even the flow rate were found to depend on the position of the rotation axis. The cases with typical rotational axis positions were calculated and analyzed. The character vortex which is generated by the rotation of the container in two-dimensional simulation in previous work dose not exist in the three dimensional simulation in this paper. The results reveal a principle for a versatile pouring process and may contribute to the applications of flowing control in many fields.
Reduced HO-1 Protein Expression is Associated with More Severe Neurodegeneration after Transient Ischemia Induced by Cortical Compression in Diabetic Goto—Kakizaki Rats (2007)

Pronounced hyperglycemia provoked by extradural compression (EC) of the sensorimotor cortex was recently described in the non-insulin dependent Goto-Kakizaki (GK) diabetic rat. Compared with control Wistar rats, GK rats exhibited more extensive brain damage after cortical ischemia at 48 h of reperfusion (Moreira et al, 2007). We hypothesized that the enhanced brain injury in GK rats could be caused by differential regulation of the heme degrading enzyme heme oxygenase (HO)-1, known to interact with the expression of other target genes implicated in antioxidant defense, inflammation and neurodegeneration, such as superoxide dismutase (SOD)-1, -2, inducible nitric oxide synthase (iNOS), and tumor necrosis factor-alpha (TNFalpha). At 48 h after ischemia, relative mRNA expression of such target genes was compared between ipsilateral (compressed) and contralateral (uncompressed) hemispheres of GK rats, along with baseline comparison of sham, uncompressed GK and Wistar rats. Immunohistochemistry was performed to detect cellular and regional localization of HO-1 at this time point. Baseline expression of HO-1, iNOS, and TNFalpha mRNA was increased in the cortex of sham GK rats. GK rats showed pronounced hyperglycemia during EC and transient attenuation of regional cerebral blood flow recovery. At 48 h after reperfusion, HO-1 mRNA expression was 7- to 8-fold higher in the ischemic cortex of both strains, being the most upregulated gene under study. Heme oxygenase-1 protein expression was significantly reduced in diabetic rats and was found in perilesional astrocytes and rare microglial cells, in both strains. The reduced HO-1 protein expression in GK rats at 48 h after reperfusion combined with more extensive neurodegeneration induced by EC, provides further in vivo evidence for a neuroprotective role of HO after brain ischemia.
Compatibility of magnesium sulfate solutions with various antibiotics during simulated Y-site injection (1984)

Journal Article Compatibility of magnesium sulfate solutions with various antibiotics during simulated Y-site injection Get access Paul F. Souney, Paul F. Souney Director of Drug Information, Assistant Clinical Professor Brigham and Women's Hospital, Massachusetts College of Pharmacy and Allied Health Sciences, Boston, MA Search for other works by this author on: Oxford Academic Google Scholar Robert D. Colucci, Robert D. Colucci Pharmacy Intern Search for other works by this author on: Oxford Academic Google Scholar Gino Mariani, M.S., Gino Mariani, M.S. Supervisor Pharmacy Services Search for other works by this author on: Oxford Academic Google Scholar David. Campbell David. Campbell Pharmacy Intern Brigham and Women's Hospital, Boston, MA Search for other works by this author on: Oxford Academic Google Scholar American Journal of Hospital Pharmacy, Volume 41, Issue 2, 1 February 1984, Pages 323–324, https://doi.org/10.1093/ajhp/41.2.323 Published: 01 February 1984
A power optimized transconductance amplifier and its application to a 6thorder lowpass GmC filter (2009)

We present the design of an ultra low power sixth-order Butterworth low pass GmC filter in 0.13µm CMOS process. A method to optimize the power consumption of a fully differential telescopic OTA is also presented to achieve an input linearity of 220 mVpp and transconductance value of 6µS. The OTA is then used to implement an ultra low power filter and to show the impact of parasitic capacitances and resistances on the system. Simulation results shows that the frequency response of the sixth order Butterworth low pass filter is achieved with high precision and a THD of −60dB for 200mVpp input signal is obtained. The overall power consumption is less than 150µW.
An FPGA-based in-line accelerator for Memcached (2013)

Presents a collection of slides covering the following topics: memcached; FPGA; hybrid architecture; and in-line accelerator generation process.
A Framework for Constraint-Based Deployment and Autonomic Management of Distributed Applications (Extended Abstract) (2010)

We propose a framework for the deployment and subsequent autonomic management of component-based distributed applications. An initial deployment goal is specified using a declarative constraint language, expressing constraints over aspects such as component-host mappings and component interconnection topology. A constraint solver is used to find a configuration that satisfies the goal, and the configuration is deployed automatically. The deployed application is instrumented to allow subsequent autonomic management. If, during execution, the manager detects that the original goal is no longer being met, the satisfy/deploy process can be repeated automatically in order to generate a revised deployment that does meet the goal.
Radionuclide Sensors for Water Monitoring (2004)

Radionuclide contamination in the soil and groundwater at U.S. Department of Energy (DOE) sites is a severe problem that requires monitoring and remediation. Radionuclide measurement techniques are needed to monitor surface waters, groundwater, and process waters. Typically, water samples are collected and transported to an analytical laboratory, where costly radiochemical analyses are performed. To date, there has been very little development of selective radionuclide sensors for alpha- and beta-emitting radionuclides such as 90Sr, 99Tc, and various actinides of interest. The objective of this project is to investigate novel sensor concepts and materials for sensitive and selective determination of beta- and alpha-emitting radionuclide contaminants in water. To meet the requirements for low-level, isotope-specific detection, the proposed sensors are based on radiometric detection. As a means to address the fundamental challenge of the short ranges of beta and alpha particle s in water, our overall approach is based on localization of preconcentration/separation chemistries directly on or within the active area of a radioactivity detector. Automated microfluidics is used for sample manipulation and sensor regeneration or renewal. The outcome of these investigations will be the knowledge necessary to choose appropriate chemistries for selective preconcentration of radionuclides from environmental samples, new materials that combine chemical selectivity with scintillating properties, new materials that add chemical selectivity to solid-state diode detectors, new preconcentrating column sensors, and improved instrumentation and signal processing for selective radionuclide sensors. New knowledge will provide the basis for designing effective probes and instrumentation for field and in situ measurements.
Diameter modulation as a route to probe the vapour–liquid–solid growth kinetics of semiconductor nanowires (2013)

A method is presented for interrogating the kinetics of semiconductor nanowire growth via the vapour–liquid–solid (VLS) technique. Morphological markers, generated via user-defined changes to diameter along the nanowire axial direction, enable the accurate and facile extraction of growth rate from scanning electron microscopy images. Trimethylsilane, SiH(CH3)3, is utilized for this purpose and does not influence growth rate and/or kinking when introduced separately from GeH4. As a proof of concept, we apply this approach to determine the diameter, temperature, and pressure dependence of Au-catalyzed Ge nanowire growth.
Parallel fault-tolerant programming of an arbitrary feedforward photonic network (2019)

Reconfigurable photonic mesh networks of tunable beamsplitter nodes can linearly transform $N$-dimensional vectors representing input modal amplitudes of light for applications such as energy-efficient machine learning hardware, quantum information processing, and mode demultiplexing. Such photonic meshes are typically programmed and/or calibrated by tuning or characterizing each beam splitter one-by-one, which can be time-consuming and can limit scaling to larger meshes. Here we introduce a graph-topological approach that defines the general class of feedforward networks commonly used in such applications and identifies columns of non-interacting nodes that can be adjusted simultaneously. By virtue of this approach, we can calculate the necessary input vectors to program entire columns of nodes in parallel by simultaneously nullifying the power in one output of each node via optoelectronic feedback onto adjustable phase shifters or couplers. This parallel nullification approach is fault-tolerant to fabrication errors, requiring no prior knowledge or calibration of the node parameters, and can reduce the programming time by a factor of order $N$ to being proportional to the optical depth (or number of node columns in the device). As a demonstration, we simulate our programming protocol on a feedforward optical neural network model trained to classify handwritten digit images from the MNIST dataset with up to 98% validation accuracy.
Avis en réponse à la saisine1 100226-saisine HCB-dossier 1507 culture concernant la partie « culture » du dossier C/ES/01/012. Paris, le 6 mai 2010 (2010)

Paris, le 6 mai 2010 A V I S en réponse à la saisine 1 100226-saisine HCB-dossier 1507 culture concernant la partie « culture » du dossier C/ES/01/01 2. Le Haut Conseil des biotechnologies (HCB) a été saisi le 24 février 2010 par les autorités compétentes françaises (la Direction générale de l'alimentation du Ministère de l'alimentation, de l'agriculture et de la pêche) d'une demande d'avis relative à une nouvelle évaluation de la partie « culture » du dossier C/ES/01/01 relatif à la mise sur le marché du maïs 1507 pour la culture, l'importation, la transformation et l'utilisation en alimentation animale. Ce dossier est déposé par Pioneer Hi-Bred International, Inc. et Mycogen Seeds (c/o Dow AgroSciences LLC), dans le cadre de la directive 2001/18/CE sous la référence C/ES/01/01. La saisine du HCB concernant la partie culture est référencée 100226-saisine HCB-dossier 1507 culture. Le Comité scientifique (CS) 3 du HCB a procédé à l'examen du dossier le 6 avril 2010 sous la présidence de Jean-Christophe Pagès. 1 La saisine « 100226-saisine HCB-dossier 1507 culture » est reproduite dans l'Annexe 1. 2 Un addendum relatif à une information communiquée par le pétitionnaire après la rédaction du présent avis a été intégré en fin d'avis p. 24. 3 La composition du CS ainsi que le rapporteur externe ayant contribué à l'élaboration de l'avis sont indiqués dans l'Annexe 2.
S4‐04‐07: Bace Inhibitors for the Treatment of Alzheimer's Disease (2009)

Beta-site amyloid precursor protein cleaving enzyme (BACE) and its homologue BACE2 are type I transmembrane aspartic acid proteases. BACE cleaves the amyloid precursor protein (APP) at the β-secretase site, generating amyloid-β peptides (Aβ) and is considered one of the key therapeutic targets for the treatment of Alzheimer's Disease (AD). Small molecule BACE inhibitors would be expected to prevent the generation of the Aβ peptides and consequently reduce the detrimental effects of Aβ toxicity and the formation of amyloid plaques in the brain. One of the major hurdles with BACE inhibitors that plague the pharma industry is achieving in vivo efficacy primarily due to poor brain penetration. We have identified potent and selective inhibitors of human BACE using rational drug design and X-ray technology. In primary mouse cortical neurons our novel small molecule BACE inhibitors display a dose dependent inhibition of Aβ release. Furthermore, we find that our BACE inhibitors inhibit Aβ in the brain and plasma of C57BL/6 mice in a concentration-dependent fashion. There is a good correlation between the concentrations required to observe these effects in primary neurons and the free concentration of inhbitor in the brain. Our results suggest that it is possible to overcome brain penetration issues and achieve efficacy in the brain with novel BACE inhibitors. These results strongly support the utility of BACE inhibitors as a technically feasible approach to therapeutic intervention in AD. These results strongly support the utility of BACE inhibitors as a technically feasible approach to therapeutic intervention in AD.
Expression of proopiocortin and proopiomelanotropin during the life cycle of the sea lamprey (Petromyzon marinus) (1999)

The sea lamprey shows an important divergence in the proopiomelanocorticotropin (POMC) prohormone in that adrenocorticotropin (ACTH) and melanocyte stimulating hormone (MSH) are encoded on distinct genes, proopiocortin (POC) and proopiomelanotropin (POM), respectively. POC encodes nasohypophysial factor (NHF), ACTH, and β-endorphin while POM encodes α- and β-MSH-like peptides (called MSH-B and MSH-A, respectively), and a second form of β-endorphin. The present study examined the variation in expression of these two genes during the life cycle of sea lampreys. Individual Northern blot analysis and pooled data from several Northern blots showed significant differential expression of POC and POM during the lamprey life cycle. While POC expression remained low over larval and metamorphic stages, POM expression rose substantially in stage 4 and stage 6 of metamorphosis. Both POC and POM expression levels increased in immediately post-metamorphic animals. The highest levels of POM expression were observed in larger juvenile adults and pre-spawners, whereas the highest level of POC expression was observed at the pre-spawning period. Statistical analysis showed POM expression to be much higher than POC expression in immediately post-metamorphic animals prior to feeding. Northern analysis of total RNA isolated from various tissues in the pre-spawning lampreys, including brain, showed expression of POC and POM only in the pituitary. These observations indicate that the expression of POC and POM, which encode different sets of hormones, may be related to developmental and maturation events during the life cycle of the sea lamprey. J. Exp. Zool. 283:95–101, 1999. © 1999 Wiley-Liss, Inc.
Occult, Bilateral Anterior Sacral and Intrasacral Meningeal and Perineurial Cysts: Case Report and Review of the Literature (1990)

Abstract None of the more than 180 cases of anterior sacral meningocele reported in the past 150 years has been bilateral, and only two have been associated with occult intrasacral meningocele. We report a unique case of bilateral anterior sacral cysts, communicating with the subarachnoid space, associated with occult intrasacral meningeal and perineurial (Tarlov's) cysts, in an asymptomatic woman. The pertinent clinical and diagnostic imaging literature is reviewed.
Cryptography with right-angled Artin groups (2017)

In this paper we propose right-angled Artin groups as a platform for secret sharing schemes based on the efficiency (linear time) of the word problem. Inspired by previous work of Grigoriev-Shpilrain in the context of graphs, we define two new problems: Subgroup Isomorphism Problem and Group Homomorphism Problem. Based on them, we also propose two new authentication schemes. For right-angled Artin groups, the  Group Homomorphism and Graph Homomorphism problems are equivalent, and the later is known to be NP-complete. In the case of the Subgroup Isomorphism problem, we bring some results due to Bridson who shows there are right-angled Artin groups in which this problem is unsolvable.
Improvement of intermetallics electrochemical behavior by playing with the composite electrode formulation (2011)

The impact of both various binders and carbon additives on the electrochemical behavior of intermetallics-based (FeSn2, NiSb2, TiSnSb) negative electrodesvs.Li was evaluated and accurately studied for FeSn2. The formulation of the composite electrode allowed enhancement of both the capacity retention as well as the rate capability. CMC/VGCF (carboxymethyl cellulose/vapor grown carbon fiber) used as a binder/conductive additive allows retention of 100% of the specific capacity during 35 cycles at 2C rate (2Li h−1), whereas the fading is dramatic after only a few cycles at a low rate with classical powdered electrodes. Notably, an extra capacity is observed with CMC/VGCF. In the case of FeSn2, it is shown that the improvement of performance achieved with CMC/VGCF results from better efficiency of the conductive additive to form an electronic percolation web around the active material (AM) particles rather than from the buffering of the volume variations of the AM particles, contrary to the case of Si-based electrodes. The improved cycle life is also likely due to the better ability of CMC to cover the particles compared to PVDF (polyvinylidene fluoride), resulting not only in stronger interparticle bonding but also in a better SEI layer. It is suggested that the growing of an insulating SEI layer by the degradation of the liquid electrolyte is an important factor in the fading mechanism of FeSn2 composite electrodes. Finally, the aqueous processing of the FeSn2, NiSb2, and TiSnSb intermetallics-based composite electrodes is feasible.
Cytokines and depression in cancer patients and caregivers (2017)

Objective: A better understanding of the biobehavioral mechanisms underlying depression in cancer is required to translate biomarker findings into clinical interventions. We tested for associations between cytokines and the somatic and psychological symptoms of depression in cancer patients and their healthy caregivers. Patients and methods: The GRID Hamilton Rating Scale for Depression (Ham-D) was administered to 61 cancer patients of mixed type and stage, 26 primary caregivers and 38 healthy controls. Concurrently, blood was drawn for multiplexed plasma assays of 15 cytokines. Multiple linear regression, adjusted for biobehavioral variables, identified cytokine associations with the psychological (Ham-Dep) and somatic (Ham-Som) subfactors of the Ham-D. Results: The Ham-Dep scores of cancer patients were similar to their caregivers, but their Ham-Som scores were significantly higher (twofold, p =0.016). Ham-Som was positively associated with IL-1ra (coefficient: 1.27, p ≤0.001) in cancer patients, and negatively associated with IL-2 (coefficient: -0.68, p =0.018) in caregivers. Ham-Dep was negatively associated with IL-4 (coefficient: -0.67, p =0.004) in cancer patients and negatively associated with IL-17 (coefficient: -1.81, p =0.002) in caregivers. Conclusion: The differential severity of somatic symptoms of depression in cancer patients and caregivers and the unique cytokine associations identified with each group suggests the potential for targeted interventions based on phenomenology and biology. The clinical implication is that depressive symptoms in cancer patients can arise from biological stressors, which is an important message to help destigmatize the development of depression in cancer patients. Keywords: depression, psychological symptoms, somatic symptoms, cytokines, cancer, caregiver
An interface circuit for a Josephson-CMOS hybrid digital system (1999)

For broadband data communication between Josephson and CMOS digital systems, amplification of small Josephson-output signals and synchronization between the systems are important issues. We present an interface circuit for a Josephson-CMOS hybrid digital system. The interface circuit consists of a parallel-in-parallel-out (PIPO) circuit and built-in Josephson-MOS amplifiers. The PIPO circuit, implemented based on 4JL latching logic technology, performs synchronized data transfer between the Josephson and CMOS circuits. The Josephson-MOS amplifiers consists of stacked Josephson junctions (Suzuki stacks) and MOS inverters which are monolithically integrated on a chip. The circuits have been designed, fabricated and tested. We have successfully confirmed correct operation of the circuits.
Malignant Transformation of Normal Enterocytes following Downregulation of Bak Expression (2008)

Bak is a pro-apoptotic gene, which plays an important role in the multi-step process of gastrointestinal tumorigenesis. We hypothesized that downregulation of Bak expression in normal enterocytes will result in a transformed phenotype. The nontumorigenic intestinal epithelial cell line (IEC18) was transfected with the vector pMV12-AS-bak (encoding anti-sense bak). Three clones, with Bak protein levels similar to those seen in colon cancer cell lines and significantly lower than those found in the parental cells, were further evaluated. The three clones proliferated faster, demonstrated anchorage-independent growth in soft agar and a higher saturation density and plating efficiency. Furthermore, when injected into nude mice, these cells generated tumors after approximately 2-3 weeks. The cells were more resistant to the induction of apoptosis by sulindac sulfide and sulindac sulfone but more sensitive to COX 2 inhibitors (celecoxib and nimesulide). The levels of p16, cyclin D1 and COX 2 were higher in the three transformed clones. In summary,downregulation of Bak expression in normal enterocytes contributes to abnormal growth and tumorigenesis. COX 2 inhibitors may serve as important agents in the prevention and treatment of CRC as they only inhibit the growth of malignant cells.