gebhart/patrepeval huggingface dataset:
Reciprocal modulation of tumor necrosis factor and gamma interferon receptors in human carcinoma cells: Biological significance and mechanisms of action. (1991)

Human recombinant cytokines may have a role in the clinical treatment of pancreatic and colorectal cancers. In the present studies, the growth inhibitory actions of recombinant human tumor necrosis factor (rhTNF) and recombinant human gamma interferon (rhIFN-γ) were examined in several human pancreatic and colorectal carcinoma cell lines in vitro in relation to the expression TNF and IFN-γ receptors. rhTNF and rhIFN-γ exerted significant, but differential, growth inhibitory effects in five of six cell lines examined. All six cell lines exhibited high affinity binding sites for both ¹²⁵I-labeled rhTNF and ¹²⁵I-labeled rhIFN-γ. However, the basal number of binding sites in general did not correlate with the relative growth inhibitory effects induced by either rhTNF or rhIFN-γ. In contrast, in three cell lines in which the cytokines exerted synergistic effects, rhTNF increased by 2-3 fold the number of ¹²⁵I-rhIFN-γ binding sites. Further, in two of these cell lines, rhIFN-γ also upregulated ¹²⁵I-rhTNF binding. As demonstrated by anti-IFN-γ receptor antibody labeling and the use of transcriptional and translational inhibitors, the increase in ¹²⁵I-rhIFN-γ binding by rhTNF was due to enhanced synthesis and expression of IFN-γ receptor protein. Recombinant human lymphotoxin (rhLT), which binds to the TNF receptor, and recombinant human interleukin-1 alpha (rhIL-1), which binds to a distinct receptor and mimicks many of the biological actions of TNF, also increased the expression of IFN-γ receptors. Further, rhIL-1 exerted synergistic growth inhibitory effects with rhIFN-γ. Taken together, these results suggest that the synergistic effects of either TNF/LT or IL-1 and IFN-γ may involve the upregulation of IFN-γ receptors. The mechanisms by which rhTNF and rhIL-1 upregulate IFN-γ receptors are unclear. However, the upregulatory effects of both rhTNF and rhIL-1 were attenuated by the Ca²⁺ ionophore A23187 and the phorbol ester 12-O-tetradecanoyl phorbol-13-acetate, suggesting that the mechanisms involved in IFN-γ receptor upregulation by TNF and IL-1 are negatively modulated by Ca²⁺ and protein kinase C activation. The results of this dissertation suggest that immunotherapy with recombinant cytokines may be useful in that treatment of pancreatic and colorectal cancer in vivo.
PHY interoperability with 11a/g legacy OFDM devices (2013)

One of the functional requirements in the development of the 802.11n standard was that some modes of operation must be backward compatible with 802.11a (and 802.11g if 2.4 GHz was supported) as described in Stephens (2005). Furthermore, the 802.11n standard development group also decided that interoperability should occur at the physical layer. This led to the definition of a mandatory mixed format (MF) preamble in 802.11n. In this chapter, we first review the 802.11a packet structure, transmit procedures, and receive procedures to fully understand the issues in creating a preamble that is interoperable between 802.11a and 802.11n devices. For further details regarding 802.11a beyond this review, refer to clause 18 in IEEE (2012). Following this overview, the mixed format preamble, which is part of 802.11n, is discussed.
Supplementary Figure 4 from Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors (2023)

Supplementary Figure 4 from Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors
Mutation screening of muscle development genes in patients with idiopathic clubfoot (2012)

Background: Congenital idiopathic clubfoot is a very common musculoskeletal birth defect, but with no known etiology. Dietz et al. have shown possible linkage in chromosome 3 and 13 in a large, multigenerational family with congenital idiopathic clubfoot. Current evidence suggests that muscle development is impaired in patients with congenital idiopathic club-foot, therefore we hypothesized that mutations in genes related to muscle development could be associated with this deformity. From the areas identified in the linkage study, candidate genes SPRY2, RAF1, IQSEC1, LMO7, and UCHL3 were selected based upon their presence in skeletal muscle as well as their involvement in muscle development. Methods: The exons and splice sites of the five genes were screened via sequence-based analysis in a group of 24 patients with congenital idiopathic clubfoot. All single nucleotide polymorphisms (SNPs) found were compared to public databases to determine allelic frequency and amino acid modification. Results: While many SNPs were found, none proved to be significantly associated with the phenotype of congenital idiopathic clubfoot. The SNPs found were shown to be common amongst a non-clubfoot population and to follow the allelic frequency of the general population. Conclusions: Based upon these results, SPRY2, RAF1, IQSEC1, LMO7, and UCHL3 are not likely to be the major causes of congenital idiopathic clubfoot. Given the complexity of myogenesis, many other candidate genes remain that could cause defects in the hypaxial musculature that is invariably observed in congenital idiopathic club-foot. Clinical Relevance: This study further identifies genes which are unlikely to be the direct cause of congenital idiopathic clubfoot. It also helps to eliminate suspected genes found within the given bounds of chromosome 3 and 13.
Cytometry technologies for analysis of very small numbers of cells (LL2-5) (2010)

Stem cells are clonogenic cells capable of both self-renewal and multilineage differentiation. During development and regeneration of a given tissue, such cells give rise initially to non-self-renewing progenitors with restricted differentiation potential, and finally to functionally mature cells while maintaining primitive stem cells. Because of these unique properties, stem cells offer the novel and exciting possibility of regenerative medicine. In addition, growing evidence supports the existence of cancer stem cells (CSCs) assumed to be responsible for cancer formation and its growth. It is evident that understanding of signaling mechanisms in these stem cells is crucial not only for transplantation and regenerative medicine but also for cancer treatment. However, our knowledge of the signaling events that control cell fate determination remains limited for any type of adult stem cells, including hematopoietic stem cells (HSCs) as well as CSCs, because of their paucity. To circumvent this issue, we have recently developed a method that allows quantitative analysis of protein expression, localization, and phosphorylation in very rare cells such as HSCs. Using this technique, we are beginning to uncover molecular mechanisms that regulate stem cell self-renewal, cell cycle, and hibernation. This technique, in combination with a cell imaging analyzer, potentially has wide applications to studies of a variety of rare normal and malignant cells.
Role of endoscopic ultrasound (EUS) in identifying pancreatic abscess masquerading as pancreatic neoplasia (2003)

Role of endoscopic ultrasound (EUS) in identifying pancreatic abscess masquerading as pancreatic neoplasia
Assessment of myocardial strain using strain-encoding (SENC) MRI: comparison of acquisition strategies (2011)

Strain-encoding (SENC) MRI was recently introduced for measuring strain with high-resolution and simple post-processing(1). Figure-​Figure-11 shows SENC pulse sequence. In typical SENC sequence, k-space data is acquired line-by-line in rectilinear fashion, which results in long scan-time and renders the technique impractical for many applications. Nevertheless, fast imaging techniques, e.g. Radial or Spiral acquisition, allow for reducing scan time while maintaining adequate image quality. In this work, Radial and Spiral acquisitions were implemented in SENC for improved performance. The developed sequences were tested on volunteers and the results were evaluated and compared to standard Cartesian acquisition.



Figure 1

SENC pulse sequence. The pulse sequence consists of two parts: modulation and imaging. The modulation part is composed of two non-selective 90° RF pulses, interspersed by a modulation gradient in the slice-selection direction, and followed by ...




Methods
Radial and Spiral acquisitions(2) were implemented in SENC, and the different sequences were tested on three volunteers on Siemens Tim-Trio 3.0-Tesla scanner. The imaging parameters were: FOV=350mm, slice-thickness =10mm, flip-angle=15°, # heart-phases=25, and scan time=17 s. The three sequences were optimized for the fixed scan-time. Maximum resolution obtained was 160x160 for Cartesian (80% phase-encoding coverage) and Radial (128 Radial spokes), and 256x256 for Spiral (10 spiralsx2 averages). The low-tuning and high-tuning images were combined together as described in(1) to construct the strain images. Strain values were measured at five different points along the lateral left-ventricular wall on all volunteers. Bland-Altman analysis was conducted to compare measurements from different sequences.
Link-protection and FIPP p-cycle designs in translucent elastic optical networks (2020)

Elastic optical networks (EONs) are able to provide high spectrum utilization efficiency due to flexibility in resource assignment. In translucent EONs, by employing regenerators and using advanced modulation formats for transmission, spectrum efficiency can be further improved. Survivability is regarded as an important aspect of EONs, and p-cycle protection is considered to be an attractive scheme due to its fast restoration and high protection efficiency. In this paper, we propose methods for evaluating and selecting p-cycles for both link protection (LP) and failure-independent path protection (FIPP) to survive single-link failures. After considering the various factors that affect the performance of a p-cycle, we propose two evaluation metrics for LP and FIPP, namely, individual p-cycle cost and set of cycles cost. Based on these metrics, we propose two algorithms for selecting a set of p-cycles in translucent EONs: Traffic Independent P-cycle Selection (TIPS), which selects a set of cycles without knowledge of the traffic, and Traffic-Oriented P-cycle Selection (TOPS), which takes given traffic information into account. A routing and spectrum assignment algorithm is designed for translucent EONs, and our p-cycle design algorithms are evaluated using both static and dynamic traffic models. Simulation results show that the proposed algorithms have better performance than commonly used baseline algorithms. We also compare the performance of LP p-cycles and FIPP p-cycles.
Small Changes in Environmental Parameters Lead to Alterations in Antibiotic Resistance, Cell Morphology and Membrane Fatty Acid Composition in Staphylococcus lugdunensis (2014)

Staphylococcus lugdunensis has emerged as a major cause of community-acquired and nosocomial infections. This bacterium can rapidly adapt to changing environmental conditions to survive and capitalize on opportunities to colonize and infect through wound surfaces. It was proposed that S. lugdunensis would have underlying alterations in metabolic homeostasis to provide the necessary levels of adaptive protection. The aims of this project were to examine the impacts of subtle variations in environmental conditions on growth characteristics, cell size and membrane fatty acid composition in S. lugdunensis. Liquid broth cultures of S. lugdunensis were grown under varying combinations of pH (6-8), temperature (35-39°C) and osmotic pressure (0-5% sodium chloride w/w) to reflect potential ranges of conditions encountered during transition from skin surfaces to invasion of wound sites. The cells were harvested at the mid-exponential phase of growth and assessed for antibiotic minimal inhibitory concentration (MIC), generation time, formation of small colony variants, cell size (by scanning electron microscopy) and membrane fatty acid composition. Stress regimes with elevated NaCl concentrations resulted in significantly higher antibiotic resistance (MIC) and three of the combinations with 5% NaCl had increased generation times (P<0.05). It was found that all ten experimental growth regimes, including the control and centroid cultures, yielded significantly different profiles of plasma membrane fatty acid composition (P<0.0001). Alterations in cell size (P<0.01) were also observed under the range of conditions with the most substantial reduction occurring when cells were grown at 39°C, pH 8 (514±52 nm, mean ± Standard Deviation) compared with cells grown under control conditions at 37°C with pH 7 (702±76 nm, P<0.01). It was concluded that S. lugdunensis responded to slight changes in environmental conditions by altering plasma membrane fatty acid composition, growth rates and morphology to achieve optimal adaptations for survival in changing environments.
New Boranophosphorylation Reagents, Dimethyl Boranophosphate Monopotassium Salt and Tetramethyl Boranopyrophosphate (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTNew Boranophosphorylation Reagents, Dimethyl Boranophosphate Monopotassium Salt and Tetramethyl BoranopyrophosphateTsuneo Imamoto, Eiji Nagato, Yoshiyuki Wada, Hideki Masuda, Kentaro Yamaguchi, and Tadafumi UchimaruView Author Information Department of Chemistry, Faculty of Science and Chemical Analysis Center, Chiba University Yayoi-cho, Inage-ku, Chiba 263, Japan Ogawa and Company Ltd., Okayama Laboratory Shoocho, Katsuta, Okayama 709-43, Japan National Institute of Materials and Chemical Research Science City 305, JapanCite this: J. Am. Chem. Soc. 1997, 119, 41, 9925–9926Publication Date (Web):October 15, 1997Publication History Received9 July 1997Published online15 October 1997Published inissue 1 October 1997https://pubs.acs.org/doi/10.1021/ja972276lhttps://doi.org/10.1021/ja972276lrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views530Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Hydrocarbons,Inorganic compounds,Reagents,Salts Get e-Alerts
Reduced Buildings Greenhouse Gas Emissions With Integrated Approach to Design, Systems and Operation (2002)

Residential and commercial buildings energy consumption is a significant source of greenhouse gas emissions in developed countries, accounting for about one-third of global energy related CO 2 emissions, compared with similar amounts for the other major sectors of transportation and industrial.The Third Assessment Report of the Intergovernmental Panel on Climate Change (IPCC) identifies buildings as the sector with the largest potential for reduced greenhouse gas emissions over the next 20 years.In the United States in 1997, heating, ventilating, air conditioning, and refrigeration (HVACR) equipment accounted for about two-thirds of residential buildings energy consumption, and one-third of commercial buildings energy consumption.Increased efficiency of HVAC equipment can certainly save energy and reduce greenhouse gas emissions; however, there is a limit to the amount of savings from considering only HVAC equipment energy efficiency. .Based on HVAC system energy efficiency limits, we must work with a wide group of buildings industry groups (architects, designers, construction, operators, service) to achieve a larger portion of the potential CO 2 emission reductions.This implies an integrated approach with all parts of the buildings sector working together.Examples are presented of how such an approach can lead to larger emission reductions, with monetary savings beyond implementation costs.These examples include building designs to reduce HVAC equipment load requirements, reduced lighting energy, and monitoring systems to detect HVAC equipment performance deterioration.
Robust group key agreement using short broadcasts (2007)

A group key agreement protocol (GKA) allows a set of players to establish a shared secret key which can be used to secure a subsequent communication. Several efficient constant-round GKA's have been proposed. However, their performance degrades if some players fail during protocol execution. This is a problem in practice, e.g. for mobile nodes communicating over wireless media, which can loose connectivity during the protocol execution. Current constant-round GKA protocols are either efficient and non-robust or robust but not efficient: Assuming a reliable broadcast communication medium, the standard encryption-based group key agreement protocol can be robust against arbitrary number of node faults, but the size of the messages broadcast by every player is proportional to the number of players. In contrast, non-robust group key agreement can be achieved with each player broadcasting just constant-sized messages.
STANDARDS ANALYSIS POWERING/PERFORMANCE EVALUATION USING TEST COURSE METHODS. VOLUME I. RESEARCH REPORT (1974)

Volume I contains the information gleaned from recent test programs conducted in the United States and Canada using various test courses to evaluate the performance of some 96 boats (less than 26 ft) in over 170 different boat/motor combinations. The report summarizes five different test programs, the tests performed, results of the tests and data obtained, and conclusions/recommendations based on the data/analysis reported. The test courses used were based upon those developed by ABYC/BIA and consist of a family of courses all of which have an entry gate and an offset (or avoidance) buoy. The course ends with an exit gate which is in-line with the entry gate. The entry/exit distances and offset distances are dependent on the boat maximum speed.
THE RELATION BETWEEN ACUTE VASCULAR AND INTERSTITIAL RENAL ALLOGRAFT REJECTION AND SUBSEQUENT CHRONIC REJECTION (1995)

Transplantation is published monthly and is the most cited and influential journal in the field, with more than 25,000 citations per year. The journal celebrated its 50th year in 2016. Transplantation has been the trusted source for extensive and timely coverage of the most important advances in transplantation. The Editors and Editorial Board are an international group of research and clinical leaders that includes many pioneers of the field, representing a diverse range of areas of expertise. This capable editorial team provides thoughtful and thorough peer review, and delivers rapid, careful and insightful editorial evaluation of all manuscripts submitted to the journal.
Pre-exercise Supplementing Lower Dose Of Soy Peptide Suppresses Serum Creatine Kinase Elevation In Soccer Players (2009)

Amino acids supplementation is effective not only to improve sport performance but also preservation of athletes' physical conditions. Many studies which investigated effects of amino acids supplementation usually adopt high dose of amino acids, whereas effects of lower dose of amino acids intake are still unclear. Pre-exercise intake of lower amounts of peptide form of amino acids, which can be more rapidly and efficiently absorbed than amino acids itself, may have positive effects on athletes' conditioning especially during in-season. PURPOSE: To investigate the effects of pre-exercise supplementation with lower dose of soy peptide on serum creatine kinase (CK) level and psychological fatigue in soccer players through in-season. METHOD: Sixteen Japanese collegiate soccer players volunteered to participate in this study which was carried out in double-blind manner. The subjects were divided into two groups of soy peptide (SP) group (N=8, age; 19.1 ± 0.6 yrs, height; 174.3 ± 4.8 cm, weight; 65.6 ± 3.5 kg), and placebo (Pl) group (N=8, age; 19.6 ± 1.4 yrs, height; 172.3 ± 6.3 cm, weight; 66.8 ± 5.9 kg). SP group was instructed to take 4,000 mg/day of soy peptide supplement one hour prior to matches or training sessions for 8 weeks, while Pl group was administrated placebo which was mainly composed of isocaloric dextrin powders. To assess physical and psychological aspects of the players' condition, serum CK level and profile of mood states (POMS) were utilized as conditioning parameters. These parameters were measured before and during the intervention period. RESULTS: Serum CK level of SP group was significantly lower than that of Pl group at the 5th week (194 ± 115 vs. 355 ± 143 U/L, p<0.05), and statistically lower trends were also observed at the 1st (248 ± 108 vs. 426 ± 235 U/L, p=0.07) and 8th week (220 ± 134 vs. 506 ± 411 U/L, p=0.08). There were no significant differences in fatigue scores of POMS. CONCLUSION: Pre-exercise supplementation with 4,000 mg/day of soy peptide can suppress elevations of serum CK level, but did not affect on subjective fatigue level in soccer players through 8 weeks of in-season.
Coalescing: Syntactic Abstraction for Reasoning in First-Order Modal Logics (2018)

We present a syntactic abstraction method to reason about first-order modal logics by using theorem provers for standard first-order logic and for propositional modal logic.
Reflexiones sobre la educación artística en las escuelas primarias públicas: sistemas de apoyo y formación de subjetividad Reflections on the artistic education at state elementary schools: sistems of support and subjetivity formation (2011)

En el presente trabajo proponemos un recorrido que retoma aspectos trabajados en el marco de nuestro proyecto de investigación: "Aprendizaje situado, interactividad y sistemas de apoyo del aprendizaje escolar en la escuela y en las familias."¹ Desde un recorte centrado en la educación artística, nos aproximamos a la indagación del lugar de las artes en las escuelas públicas y retomamos los aportes conceptuales de Vigotski para pensar una unidad de análisis que contemple los procesos que se pondrían en juego en las actividades artísticas. Además, realizamos una revisión teórica donde destacamos aportes de la etnografía, la reconceptualización de la noción de apropiación y la idea de disenso con la intención de continuar la reflexión acerca de posibles transformaciones para las prácticas educativas.<br>In this abstract we propose a path wich takes some aspects already worked in our research framework: Situated learning, interactivity and systems of learning support at schools and in the families". From an artistic education point of view, we approach to an investigation on the place of arts at state schools and we retake Vigotski s conceptual perspective to think and analysis unit which considers the processes that may take place along artistic activities. Besides, we make a theoretical revision in which we emphasize the ethnography contributions and the reconceptualization of the notion of appropriation and the idea of dissent with the intention to continue the relection about possible transformation for the educational practices.
ChemInform Abstract: Metal‐Catalyzed Kinetic Resolution Processes (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.