gebhart/patrepeval huggingface dataset:
Study of ψ(2S) production and cold nuclear matter effects in pPb collisions at s N N = 5 $$ \sqrt{s_{N\;N}}=5 $$ TeV (2016)

The production of (2S) mesons is studied in dimuon final states using protonlead (pPb) collision data collected by the LHCb detector. The data sample corresponds to an integrated luminosity of 1.6 nb -1 . The nucleon-nucleon centre-of-mass energy of the pPb collisions is s N N = 5 TeV. The measurement is performed using (2S) mesons with transverse momentum less than 14 GeV/c and rapidity y in the ranges 1.5 < y < 4.0 and -5.0 < y < -2.5 in the nucleon-nucleon centre-of-mass system. The forward-backward production ratio and the nuclear modification factor are determined for (2S) mesons. Using the production cross-section results of (2S) and J/ mesons from b-hadron decays, the b b cross-section in pPb collisions at s N N = 5 TeV is obtained.
An inversion inv(4)(p12–p15.3) in autistic siblings implicates the 4p GABA receptor gene cluster (2006)

Despite this, the identification of an inversion breakpoint disrupting GABRG1 provides solid support for the genetic involvement of the short arm of chromosome 4 in the genetic aetiology of autism, and for the hypothesis of disrupted GABA neurotransmission in autism.
CD24 is a novel oncogene in colorectal cancer, detected by microarray profiling of cell transformation, and is a target for immunotherapy of cancer. (2006)

B136 Aims:To identify genes that play a role in colorectal cancer (CRC) carcinogenesis by analysis of differential gene expression of normal and transformed CRC cell lines. Methods : Gene expression array analysis, (RG-U34) Genechip®, was performed in normal and transformed rat intestinal epithelial cells before and after exposure to celecoxib (Pfizer, New York, NY, USA). In particular, we were looking for: a. altered gene expression in the transformed cells that reverts to normal following exposure to a selective COX2 inhibitor of. b. Novel genes. c. Genes encoding membrane receptors or ligands. As a validation of the results and for human patients, immunohistochemistry was performed on 398 biological samples from the GI tract (normal, polyps and adenocarcinomas). Human cancer cell lines were tested for their response to anti-CD24 monoclonal antibodies. Three different antibodies were added separately to the medium at different concentrations or durations; viability was measured by Methylene blue assay. CD24 cellular levels in HT29 CRC cell line were stably down regulated using siRNA technology and changes in their proliferation capacities were examined. Results : 1081 genes were differently expressed following malignant transformation; 71 genes showed alter expression that reverted to normal following treatment with celecoxib, among them was the gene to CD24. Immunohistochemistry confirmed that increased expression of CD24 is an early event in CRC carcinogenesis. It was expressed in 90.7% of adenomas and 86.3% of CRC. Very low expression was seen in normal epithelium (16.6%). Human cancer cell lines showed growth inhibition in response to the antibodies, according to their expression levels of CD24 and in dose and time dependent manners. These results were repetitive for three different antibodies. The derivatives of HT29 that showed reduced levels of CD24 following transfections with two siRNA expression vectors that differ in their binding sites, showed a significant reduction in growth rate when compared to parental HT29 and HT29 with a control-siRNA and a higher level of apoptosis in FACS analysis. Conclusions : CD24 is a new gene that is overexpressed in the colonic mucosa, already at an early stage of carcinogenesis and might play a role in tumor progression. Therefore, it is likely to be a useful biomarker for early detection and might be of use as a new target in CRC therapy.
Wind Energy Generation by Forced Vortex Shedding (2023)

Alternating slot-blowing (ASB) on a circular cylinder is used to generate energy from the wind by directly exciting or forcing the vortex shedding instability. Low amplitude excitation produces energetic peaks near the natural vortex shedding frequency, while high amplitude forcing relies on circulation control associated the unsteady Coandă effect to produce energy over a large low-frequency bandwidth. The ASB system produces 3.8 times higher net peak power with a 7.3 times greater bandwidth than a conventional VIV energy harvester, and is potentially a technological game-changer.
Phenotypic and genotypic characterization of virulence factors of Escherichia coli isolated from broiler chickens with simultaneous occurrence of cellulitis and other colibacillosis lesions. (2001)

The objective of this study was to characterize virulence factors of Escherichia coli isolates from broilers with simultaneous occurrence of cellulitis and other colibacillosis lesions. Thirty flocks were sampled and 237 birds with cellulitis were examined. Eighty-two (34.6%) of 237 birds condemned for cellulitis had gross lesions in the heart, air sacs, joints, or liver. In 58 chickens, E. coli was isolated from both the cellulitis and other lesions of colibacillosis, and 18.9% of the E. coli isolates from the 2 types of lesions belonged to the same O group. Escherichia coli of serogroups O78, O1, and O2 predominated. Isolates of the same serogroup that were derived from different lesions in the same birds had similar patterns of biotype, aerobactin production, serum sensitivity profile, antibiotic sensitivity, and K1 capsule production. Escherichia coli derived from cellulitis lesions produced virulence factors similar to those found in E. coli isolated from other colibacillosis lesions in poultry.
ChemInform Abstract: Diguanidino and “Reversed” Diamidino 2,5‐Diarylfurans as Antimicrobial Agents. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Image Guided Localized 31 P Magnetic Resonance Spectroscopy of Acute Urinary Tract Obstruction (1991)

Using 31P magnetic resonance spectroscopy, localized spectroscopy and magnetic resonance imaging we studied effects of acute urinary obstruction in the in vivo pig kidney. Accumulation of urine in the renal pelvis and collecting ducts resulted in the appearance of a new peak in the localized phosphorus spectra originating in the renal papilla, resonating at 3.43 to 4.56 ppm. This was inorganic phosphate with a pH of 5.60 to 6.79 (urine pH). Imaging did not show any dilatation of renal pelvis. There was a significant time dependent fall in renal [ATP] during urinary obstruction followed by a rapid "overshoot" of [ATP] and disappearance of the phosphate peak after release of obstruction. Possible mechanisms for this phenomenon are discussed. We conclude that 31P magnetic resonance spectroscopy provides early evidence of urinary obstruction in vivo and could be of value in clinical diagnosis.
Methoxyphenyl chalcone sensitizes aggressive epithelial cancer to cisplatin through apoptosis induction and cancer stem cell eradication (2017)

Current standard chemotherapy for late stage ovarian cancer is found unsuccessful due to relapse after completing the regimens. After completing platinum-based chemotherapy, 70% of patients develop relapse and resistance. Recent evidence proves ovarian cancer stem cells as the source of resistance. Therefore, treatment strategy to target both cancer stem cells and normal stem cells is essential. In this study, we developed a novel chalcone derivative as novel drug candidate for ovarian cancer treatment. We found that methoxyphenyl chalcone was effective to eliminate ovarian cancer cells when given either as monotherapy or in combination with cisplatin. We found that cell viability of ovarian cancer cells was decreased through apoptosis induction. Dephosphorylation of Bcl2-associated agonist of cell death protein was increased after methoxyphenyl chalcone treatment that led to activation of caspases. Interestingly, this drug also worked as a G2/M checkpoint modulator with alternative ways of DNA damage signal-evoking potential that might work to increase response after cisplatin treatment. In addition, methoxyphenyl chalcone was able to suppress autophagic flux and stemness regulator in ovarian spheroids that decreased their survival. Therefore, combination of methoxyphenyl chalcone and cisplatin showed synergistic effects. Taken together, we believe that our novel compound is a promising novel therapeutic agent for effective clinical treatment of ovarian cancer.
LineSwitch: Tackling Control Plane Saturation Attacks in Software-Defined Networking (2016)

Software defined networking (SDN) is a new networking paradigm that in recent years has revolutionized network architectures. At its core, SDN separates the data plane, which provides data forwarding functionalities, and the control plane, which implements the network control logic. The separation of these two components provides a virtually centralized point of control in the network, and at the same time abstracts the complexity of the underlying physical infrastructure. Unfortunately, while promising, the SDN approach also introduces new attacks and vulnerabilities. Indeed, previous research shows that, under certain traffic conditions, the required communication between the control and data plane can result in a bottleneck. An attacker can exploit this limitation to mount a new, network-wide, type of denial of service attack, known as the control plane saturation attack. This paper presents LineSwitch, an efficient and effective data plane solution to tackle the control plane saturation attack. LineSwitch employs probabilistic proxying and blacklisting of network traffic to prevent the attack from reaching the control plane, and thus preserve network functionality. We implemented LineSwitch as an extension of the reference SDN implementation, OpenFlow, and run a thorough set of experiments under different traffic and attack scenarios. We compared LineSwitch to the state of the art, and we show that it provides at the same time, the same level of protection against the control plane saturation attack, and a reduced time overhead by up to 30%.
Biotinylation of Bacillus thuringiensis Insecticidal Crystal Proteins (1993)

Biotinylation of Bacillus thuringiensis insecticidal crystal proteins (ICPs) was evaluated for its potential use in an alternative ICP screening method and in the characterization of ICP receptors. In vivo biological activity of CryIA(b), as inferred from bioassays with Manduca sexta and Ostrinia nubilalis and from histopathological effects on O. nubilalis midgut cells induced by force feeding, was not affected by biotinylation at moderate biotinylation ratios. A competitive radioreceptor assay showed that there was only a minor reduction in binding affinity of biotin-labeled CryIA(b) for M. sexta brush border membrane vesicles. On midgut tissue sections, the binding pattern along the midgut epithelium and the staining intensity of biotinylated ICPs detected with streptavidin-enzyme conjugate were virtually identical to the binding pattern and staining intensity of native CryIA(b) detected with antibodies. The specificity of biotinylated ICP binding to larval midgut tissue was demonstrated by performing homologous competition experiments. The relationship between different ICP receptor types in Plutella xylostella, as inferred from radioligand binding studies, was confirmed by the results of heterologous competition experiments performed with biotinylated and native ICPs.
Long-Term Outcomes of Pedicled Gastrocnemius Flaps in Total Knee Arthroplasty (2018)

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Effects of an Angiotensin II Receptor Antagonist, CV-11974, on Angiotensin II-Induced Increases in Cytosolic Free Calcium Concentration, Hyperplasia, and Hypertrophy of Cultured Vascular Smooth Muscle Cells (1994)

The effects of CV-11974, a potent nonpeptide antagonist of the angiotensin II (AII) type-1 receptor (AT1), on cytosolic free calcium concentration ([Ca2+]i), hyperplasia, and hypertrophy of cultured vascular smooth muscle cells (VSMC) from rat aorta were studied. [Ca2+]i was measured by fura 2, and hyperplasia and hypertrophy were determined by incorporation of [3H]thymidine and [3H]leucine, respectively. CV-11974 had no effect on [Ca2+]i itself, but suppressed 10(-7) M AII-induced increase in [Ca2+]i dose dependently at concentrations from 10(-10) M and completely at 10(-7) M. CV-11974 suppressed both Ca2+ release from intracellular Ca2+ stores and Ca2+ influx from the extracellular space. However, CV-11974 had no effect on the increases in [Ca2+]i induced by prostaglandin F2 alpha (PGF2 alpha), a potent vasoconstrictor, or ionomycin, a Ca2+ ionophore. These results indicate that the suppressive effects of CV-11974 act on the binding of AII and its specific receptors. AII 10(-7) M increased the synthesis of DNA and protein to 1.5 and 1.7 times the control values, respectively. CV-11974 had no effect on synthesis of DNA or protein, but suppressed the AII-stimulated synthesis of DNA and protein dose dependently at concentrations > or = 10(-8) and 10(-10) M, respectively and completely at 10(-6) M. These results indicate that AII increases [Ca2+]i and synthesis of DNA and protein in VSMC through activation of AT1. CV-11974 showed no partial agonistic effects on AII. Thus, CV-11974 may act not only as an antihypertensive agent, but also as an inhibitor of vascular injury stimulated by AII.
Measurement of Compressive and Shear Forces in Multi-Ring Media Mill. (1997)

The primary purpose of this study is to examine the movement of the grinding ring in the vessel, to measure the compressive force due to the grinding rings, and to measure the power consumption without powder loading. We also intend to determine the shear force on the vessel wall and to discuss the relationship between the compressive and shear forces.
Low loss (/spl sim/1.4 dB) 200 GHz-16ch athermal AWG compact module for metro/access network (2005)

We have developed a low loss (/spl sim/1.4dB) 200 GHz-16ch athermal AWG compact module for a metro/access network. A size of the module was achieved a reduction of about 35% in comparison with the conventional module.
Lack of Serologic Association Between Human Herpesvirus-8 Infection and Multiple Myeloma and Monoclonal Gammopathies of Undetermined Significance (1998)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
Review of: “CERAMIC MATERIALS FOR ELECTRONICS: PROPERTIES AND APPLICATIONS” Edited by Relva C. Buchanan 1986, Published by Marcel Dekker, Inc., 270 Madison Avenue, New York, New York 10016, $79.75 (U.S. and Canada), $95.50 (All other countries). (1989)

(1989). Review of: “CERAMIC MATERIALS FOR ELECTRONICS: PROPERTIES AND APPLICATIONS” Edited by Relva C. Buchanan 1986, Published by Marcel Dekker, Inc., 270 Madison Avenue, New York, New York 10016, $79.75 (U.S. and Canada), $95.50 (All other countries). Materials and Manufacturing Processes: Vol. 4, No. 3, pp. 449-450.
Joint Congestion Control and OFDMA Scheduling for Hybrid Wireline-Wireless Networks (2007)

We consider joint congestion control and multiuser scheduling in a hybrid wireline and wireless network, where the air interface of wireless links is based on orthogonal frequency division multiplexing (OFDM). For static channels, we formulate this cross-layer design as a network utility maximization (NUM) problem with both wireline and wireless link constraints. The convexity of the problem enables a well-established dual-based approach to decompose it into two subproblems, the transport layer source rate adaptation and the medium access control (MAC) layer multiuser OFDM scheduling, which are connected and coordinated by link prices. While the rate and link price adjustments follow the same fashion as the conventional utility-based congestion control for wireline networks, the key difference is the multiuser OFDM scheduling performed at the wireless access point (AP). Independent from specific utilities used by each source, this scheduling problem always maximizes a wireless link-price-weighted sum throughput (LPWST), which can be solved efficiently by a block-coordinate descent method, resulting in optimal subcarrier assignment and power allocation at the AP. Convergence of the dual-based algorithm is established using the convex optimization theory. To extend our results to dynamic wireless channels, we provide a NUM formulation with long-term average feasible rate region and develop a gradient scheduling algorithm to handle channel variations. Our work represents a systematic cross-design framework for distributed fair resource allocation in a hybrid network with both static and dynamic wireless channels.
Striatal degeneration induced by mitochondrial blockade is prevented by biologically delivered NGF (1993)

Consistent with the notion that a defect in cellular energy metabolism is a cause of human neurodegenerative disease, systemic treatment with the mitochondrial complex II inhibitor 3-nitropropionic acid (3-NPA) can model the striatal neurodegeneration seen in Huntington's disease. Previously, we have found that nerve growth factor (NGF), delivered biologically by the implantation of a genetically altered fibroblast cell-line, can protect locally against striatal degeneration induced by infusions of high doses of glutamate receptor agonists. We now report that implantation of NGF-secreting fibroblasts reduces the size of adjacent striatal 3-NPA lesions by an average of 64%. We conclude that biologically delivered NGF protects neurons against excitotoxicity and mitochondrial blockade--both energy-depleting processes--implying that appropriate neurotrophic support in the adult brain could protect against neurodegenerative diseases caused in part by energy depletion.
Experimentally Determined Neutral Density and Plasma Parameters in a 30 CM Ion Engine (2004)

range of 1 to 7.9 eV and an electron density range of 4e10 to 1e13 cm-3, throughout the discharge chamber, consistent with the results in the literature [1-2]. Plasma potential estimates, computed from the first derivative of the probe characteristic, indicate potential from 0.5V to 11V above the discharge voltage along the thruster centerline. These values are believed to be excessively high due to poor saturation of the probe IV characteristic in the low-density regions of the plasma. Relative neutral density profiles are also obtained with a fiber optic probe sampling photon flux from the 823.1 nm excited to ground state transition. Plasma parameter measurements and neutral density profiles will be presented as a function of probe location and engine discharge conditions. A discussion of the measured electron energy distribution function will also be presented, with regards to variation from pure maxwellian. It has been found that there is a distinct primary population along the thruster centerline, which causes estimates of electron temperature, electron density, and plasma potential, to err on the high side, due this energetic population. Computation of the energy distribution function of the plasma clearly indicates the presence of primaries, whose presence become less obvious with radial distance from the main discharge plume.
Enhanced hardness in epitaxial TiAlScN alloy thin films and rocksalt TiN/(Al,Sc)N superlattices (2014)

High hardness TiAlN alloys for wear-resistant coatings exhibit limited lifetimes at elevated temperatures due to a cubic-AlN to hexagonal-AlN phase transformation that leads to decreasing hardness. We enhance the hardness (up to 46 GPa) and maximum operating temperature (up to 1050 °C) of TiAlN-based coatings by alloying with scandium nitride to form both an epitaxial TiAlScN alloy film and epitaxial rocksalt TiN/(Al,Sc)N superlattices on MgO substrates. The superlattice hardness increases with decreasing period thickness, which is understood by the Orowan bowing mechanism of the confined layer slip model. These results make them worthy of additional research for industrial coating applications.
The humoral immune response to head and neck cancer antigens as defined by the serological analysis of tumor antigens by recombinant cDNA expression cloning. (2004)

Learning to identify tumor and tumor-associated antigens in patients with squamous cell carcinoma of the head and neck (HNSCC) may bring about better diagnostic and prognostic evaluations of the disease, innovative therapies based on immunological approaches, and a better understanding of the biology of tumorigenesis. Serological analysis of tumor antigens by recombinant cDNA expression cloning (SEREX) has been used to identify antigens in head and neck cancer to which patients have produced high-titered IgG antibodies. Four cDNA expression libraries have been screened with sera from 6 head and neck cancer patients. Thirty-seven individual gene products were identified. Thirty-one previously characterized proteins and 6 genes coding for molecules that are only partially characterized or novel were isolated. Tissue expression was evaluated by Northern blot analysis, RT-PCR, and in one case, quantitative real-time PCR (qPCR) using Taqman technology. Clone AU-HN-15 encoded a protein highly expressed in HNSCC tissues and cell lines. Tissue adjacent to the tumor had negligible expression. There was low or negligible expression in normal tissues, except for the brain and thymus. AU-HN-15 is identical to KIAA0530; it is an uncharacterized protein previously cloned from brain tissue and has a zinc finger domain. The cDNA encoding this protein has also been isolated in SEREX screens of testicular cancer, breast cancer, and colorectal cancer. Whether AU-HN-15 represents a tumor-antigen target suitable for prognostic or therapeutic purposes is still being analyzed.