gebhart/patrepeval huggingface dataset:
Crystal structures of 1′-aminocobaltocenium-1-carboxylic acid chloride monohydrate and of its azo dye 1′-[2-(1-amino-2,6-dimethylphenyl)diazen-1-yl]cobaltocenium-1-carboxylic acid hexafluoridophosphate monohydrate (2019)

1'-Amino-cobaltocenium-1-carb-oxy-lic acid chloride, [Co(C<sub>5</sub>H<sub>6</sub>N)(C<sub>6</sub>H<sub>5</sub>O<sub>2</sub>)]Cl·H<sub>2</sub>O, (<b>3</b>), and its azo derivative 1'-[2-(1-amino-2,6-dimethylphenyl)diazen-1-yl]cobaltocenium-1-carb-oxy-lic acid hexa-fluorido-phosphate, [Co(C<sub>13</sub>H<sub>14</sub>N<sub>3</sub>)(C<sub>6</sub>H<sub>5</sub>O<sub>2</sub>)]PF<sub>6</sub>·H<sub>2</sub>O (<b>5</b>) were obtained from cobaltocenium-1,1'-di-carb-oxy-lic acid hexa-fluorido-phosphate by converting one carboxyl group to its chloro-carboxyl derivative followed by chloride/azide exchange, Curtius rearrangement, diazo-tiation and azo coupling with 2,6-di-methyl-aniline. Both title compounds crystallize as their monohydrates. In the crystal structure of <b>3</b>, both functional groups lie in the same direction, with the Cp rings being nearly eclipsed, and participate in an extended hydrogen-bonded supra-molecular network including the counter-ion and the water mol-ecule of crystallization. Although the functional groups in <b>5</b> are somewhat further apart, bearing a greater torsion angle with the Cp rings now staggered, a similar supra-molecular network is observed with not only the carb-oxy-lic acid and azo groups, but also with the more remote amino group participating in a hydrogen-bonded network, again including the counter-ion and the water mol-ecule. The hexa-fluorido-phosphate ion shows positional disorder. Compound <b>3</b> was refined as an inversion twin. In <b>5</b>, each of the six F atoms is disordered over two sets of sites in a 1:1 ratio.
New Molecular Markers for Prostate Tumor Imaging: A Study on 2‐Methylene Substituted Fatty Acids as New AMACR Inhibitors (2011)

The development of prostate carcinoma is associated with alterations in fatty acid metabolism. α-Methylacyl-CoA racemase (AMACR) is a peroxisomal and mitochondrial enzyme that catalyses interconversion between the (S)/(R)-isomers of a range of α-methylacyl-CoA thioesters. AMACR is involved in the β-oxidation of the dietary branched-chain fatty acids and bile acid intermediates. It is highly expressed in prostate (more than 95 %), colon (92 %), and breast cancers (44 %) but not in the respective normal or hyperplastic tissues. Thus, targeting of AMACR could be a new strategy for molecular imaging and therapy of prostate and some other cancers. Unlabeled 2-methylenacyl-CoA thioesters (12 a-c) were designed as AMACR binding ligands. The thioesters were tested for their ability to inhibit the AMACR-mediated epimerization of (25R)-THC-CoA and were found to be strong AMACR inhibitors. Radioiodinated (E)-(131) I-13-iodo-2-methylentridec-12-enoic acid ((131) I-7 c) demonstrated preferential retention in AMACR-positive prostate tumor cells (LNCaP, LNCaP C4-2wt and DU145) compared with both AMACR-knockout LNCaP C4-2 AMACR-siRNA and benign BPH1 prostate cell lines. A significant protein-bound radioactive fraction with main bands at 47 (sum of molecular weights of AMACR plus 12 c), 70, and 75 kDa was detected in LNCaP C4-2 wt cells. In contrast, only negligible amounts of protein-bound radioactivity were found in LNCaP C4-2 AMACR-siRNA cells.
A novel hybrid current-limiting circuit breaker for medium voltage: principle and test results (2004)

Summary form only given. Although many attempts have been made to design a fault-current limiting (FCL) circuit breaker (FCLCB) for medium voltage electric power systems, no economically attractive solution has been achieved so far. In this paper, a novel concept for a FCLCB is introduced based on a hybrid arrangement of semiconductors, temperature-dependent resistors, and a newly developed fast-opening mechanical switch. The latter utilizes one part of an electrodynamic repulsion drive, which is concurrent with the moving double-contact system. Laboratory tests as well as computer simulations of the complete FCLCB verify as an example the feasibility of the goal ratings 12 kV and 2/20 kA (single-phase). A cost analysis shows the FCLCB to be more expensive than a conventional generator circuit breaker, but to be in the price range of the Is-limiter and below the cost of the superconducting FCL principles. It is concluded that the presented method provides the basis for further commercial product development.
Search for vectorlike leptons in multilepton final states in proton-proton collisions at s=13  TeV (2019)

A search for vectorlike leptons in multilepton final states is presented. The data sample corresponds to an integrated luminosity of 77.4 fb -1 of proton-proton collisions at a center-of-mass energy of 13 TeV collected by the CMS experiment at the LHC in 2016 and 2017. Events are categorized by the multiplicity of electrons, muons, and hadronically decaying leptons. The missing transverse momentum and the scalar sum of the lepton transverse momenta are used to distinguish the signal from background. The observed results are consistent with the expectations from the standard model hypothesis. The existence of a vectorlike lepton doublet, coupling to the third-generation standard model leptons in the mass range of 120-790 GeV, is excluded at 95% confidence level. These are the most stringent limits yet on the production of a vectorlike lepton doublet, coupling to the third-generation standard model leptons.
Border patrol: Insights into the unique role of perlecan/heparan sulfate proteoglycan 2 at cell and tissue borders (2013)

The extracellular matrix proteoglycan (ECM) perlecan, also known as heparan sulfate proteoglycan 2 or HSPG2, is one of the largest (>200 nm) and oldest (>550 M years) extracellular matrix molecules. In vertebrates, perlecan's five-domain structure contains numerous independently folding modules with sequence similarities to other ECM proteins, all connected like cars into one long, diverse complex train following a unique N-terminal domain I decorated with three long glycosaminoglycan chains, and an additional glycosaminoglycan attachment site in the C-terminal domain V. In lower invertebrates, perlecan is not typically a proteoglycan, possessing the majority of the core protein modules, but lacking domain I where the attachment sites for glycosaminoglycan chains are located. This suggests that uniting the heparan sulfate binding growth factor functions of domain I and the core protein functions of the rest of the molecule in domains II-V occurred later in evolution for a new functional purpose. In this review, we surveyed several decades of pertinent literature to ask a fundamental question: Why did nature design this protein uniquely as an extraordinarily long multifunctional proteoglycan with a single promoter regulating expression, rather than separating these functions into individual proteins that could be independently regulated? We arrived at the conclusion that the concentration of perlecan at functional borders separating tissues and tissue layers is an ancient key function of the core protein. The addition of the heparan sulfate chains in domain I likely occurred as an additional means of binding the core protein to other ECM proteins in territorial matrices and basement membranes, and as a means to reserve growth factors in an on-site depot to assist with rapid repair of those borders when compromised, such as would occur during wounding. We propose a function for perlecan that extends its role from that of an extracellular scaffold, as we previously suggested, to that of a critical agent for establishing and patrolling tissue borders in complex tissues in metazoans. We also propose that understanding these unique functions of the individual portions of the perlecan molecule can provide new insights and tools for engineering of complex multi-layered tissues including providing the necessary cues for establishing neotissue borders.
A study of discriminative feature extraction for i-vector based acoustic sniffing in IVN acoustic model training (2012)

Recently, we proposed an i-vector approach to acoustic sniffing for irrelevant variability normalization based acoustic model training in large vocabulary continuous speech recognition (LVCSR). Its effectiveness has been confirmed by experimental results on Switchboard- 1 conversational telephone speech transcription task. In this paper, we study several discriminative feature extraction approaches in i-vector space to improve both recognition accuracy and run-time efficiency. New experimental results are reported on a much larger scale LVCSR task with about 2000 hours training data.
Polarisation dependent coupling in ring resonator filters (2003)

We observed a strong polarisation dependence of the coupling between a straight dielectric strip and a ring waveguide. Based on measurements, we explain this behaviour with numerical and analytical vector-field models for a wedge-type inhomogeneity.
High performance electrospinning system for fabricating highly uniform polymer nanofibers (2009)

A high performance electrospinning system has been successfully developed for production of highly uniform polymer nanofibers. The electrospinning system employed a proportional integral-derivative control action to maintain a constant current during the production of polyvinyl acetate (PVAc) nanofibers from a precursor solution prepared by dissolution of the PVAc powder in dimethyl formamide so that high uniformity of the nanofibers was achieved. It was found that the cone jet length observed at the end of the needle during the injection of the precursor solution and the average diameter of the nanofibers decreased with decreasing Q/I, where Q is the flow rate of the precursor solution of the nanofibers and I is the current flowing through the electro spinning system. A power law obtained from the relation between the average diameter and Q/I is in accordance with the theoretical model.
Does maternal-fetal incompatibility lead to neurodevelopmental impairment? (1985)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
RAY TRACING PATH LOSS PREDICTION IN URBAN ENVIRONMENT @ 26, 28 AND 38 GHZ (2018)

A ray tracing prediction tool with advanced implementations such as diffuse scattering and vegetation attenuation, is validated vs. mm-Wave frequencies measurements in urban environment at 26GHz and 38GHz. This is one of the first investigations at these frequencies in outdoor scenario. Simulations are compared with measurements in terms of path loss in two different urban scenarios. Results show that the contribution from non-specular components in non-line-of-sight conditions is determinant to achieve a good prediction accuracy at these frequencies and that the excess loss due to vegetation cannot be neglected. To sum up, the prediction accuracy is good and simulations are generally able to track the measurements behavior.
Statically Stable Assembly Sequence Generation for Many Identical Blocks (2007)

This work develops optimal assembly sequences for&#13;\nmodular building blocks. The underlying concept is that an&#13;\nautomated device could take a virtual shape such as a CAD&#13;\nfile, and decide how to physically build the shape using simple,&#13;\nidentical building blocks. The primary focus of this work&#13;\nis the development of methods for generating assembly sequences&#13;\nin a time-feasible manner that ensure static stability&#13;\nat each step of the assembly. This is accomplished by&#13;\na multi-hierarchical rule-based approach, consisting of a set&#13;\nof low-level, mid-level and high-level assembly rules. Both&#13;\nhigh-level and mid-level assembly rules are primarily based&#13;\non static considerations. The best performing rules are presented&#13;\nand their behavior is analyzed.
A fixed-distance plane wave method for estimating the ultrasound coefficient of nonlinearity (2018)

A practical method is proposed to assess the ultrasound coefficient of nonlinearity of a medium by measuring the fundamental and 2nd harmonic in the near field of a plane piston source for varying source pressure. The method uses the Fubini solution to extract the slope of the linear dependency of the ratio harmonic/fundamental on the fundamental pressure measured at the same location. It eliminates the need for a motion stage, required by methods observing harmonic growth with source distance. It also excludes the need to measure the pressure at the source, since, in the current experiment, conducted in distilled water, it neglects depletion of the fundamental due to attenuation and energy transfer to higher harmonics. The variability of the estimated beta was evaluated with 9 measurements for which the setup was mounted anew. This was performed for 4 different distances from the source. The estimated beta slightly decreased with increasing distance from the source, possibly due to focusing effects. The average beta estimated over all measurements was 3.48+−0.43, showing good agreement with previously reported values. The reproducibility and accuracy of the proposed method is relevant for its adoption aimed at beta measurements in tissue samples for clinical diagnostic research.
Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma (2019)

Pim kinases have been targets of interest for a number of therapeutic areas. Evidence of durable single-agent efficacy in human clinical trials validated Pim kinase inhibition as a promising therapeutic approach for multiple myeloma patients. Here, we report the compound optimization leading to GDC-0339 (16), a potent, orally bioavailable, and well tolerated pan-Pim kinase inhibitor that proved efficacious in RPMI8226 and MM.1S human multiple myeloma xenograft mouse models and has been evaluated as an early development candidate.
Macromodeling of microwave structures based on noisy frequency-domain data (2006)

Frequency-domain macromodeling tools are of paramount importance for the design and study of microwave structures. In this paper, a reliable identification method, called orthormal vector fitting method, is combined with a relaxation constraint. This leads to more accurate fitting models, in a limited amount of computation time, especially if the spectral data is contaminated with noise. Its performance is analyzed on a measurement-based example and compared to other existing approaches in the field.
Endoscopic reduction of a jejunogastric intussusception (2011)

Jejunogastric intussusception (JGI) is a rare complication of gastric surgery (incidence < 0.1 %), in particular of Billroth II procedures [1]. Postoperative JGI may present any time between a few days and up to 30 years after surgery [1]. The standard treatment is emergency surgery to prevent the development of severe complications, such as gangrene and perforation of the bowel; however, the perioperative mortality is as high as 10 % – 50 % [2]. Endoscopic management of JGI has been reported in a few cases as a possible alternative to surgery, although the risk of recurrence has been highlighted [3] [4]. We describe here the successful endoscopic reduction of a JGI without recurrence in a 2-year follow-up period.
Design and construction of a multi-slice, depth-of-interaction MR-compatible PET (2005)

We are now developing a multi-slice depth-of interaction (DOI) MR-compatible PET system The MR compatible PET system is for imaging small animals such as mouse or rat. The PET system employs previously reported concept of the DOI block detectors made of scintillators, optical fibers, and multi-channel position sensitive photo-multiplier tubes (PSPMTs). The scintillator was changed from LSO to MLS. The size of a single MLS was enlarged to 2.5 mm/spl times/3.5 mm/spl times/3.5 mm to increase the system sensitivity. Eight MLSs were combined to form a DOI block detector and connected to four optical fibers via light guides. Thirty two sets of block detectors were arranged in a circular ring of which diameter is 51 mm. Full sets of the DOI block detectors were fabricated and arranged in the ring. Position histograms showed reasonable separations for all block detectors. The MR compatible PET system will have 3 imaging slice, two layers DOI detection capability, and spatial resolutions of around 2 mm FWHM in transaxail and axial directions.
MCPIP1 restrains mucosal inflammation by orchestrating the intestinal monocyte to macrophage maturation via an ATF3-AP1S2 axis (2022)

Macrophage-specific <i>Mcpip1</i> deficiency polarises macrophages towards M1-like phenotype, arrests macrophage maturation and exacerbates intestinal inflammation in an Atf3-Ap1s2-dependent manner, thus providing novel mechanistic insight into intestinal macrophage functions during IBD.
Bladder botulinum toxin A injection can benefit patients with radiation and chemical cystitis (2008)

These preliminary results suggest that BoNT-A injected into the bladder is a promising treatment for patients with refractory radiation and BCG cystitis.
Hematopoietic Stem Cells in the Mouse Spleen (2008)

Abstract The spleen is a hematopoietic organ in mice. Hematopoietic stem cells (HSCs) migrate into the spleen around embryonic day 14, and then migrate into the bone marrow (BM) around embryonic day 17. Thereafter, HSCs reside in both BM and spleen throughout the life of a mouse. The spleen is the major site of extramedullary hematopoiesis in pathological conditions. The spleen serves as an active hematopoietic organ in lethally irradiated mice for a while after transplantation with BM cells. Osteoblasts are considered to be one of the stem cell niche components. Because there are no osteoblasts in the spleen, niches in the spleen possibly functions differently from ones in the BM. The regulation of HSCs likely differs between the BM and spleen. In order to understand a role of spleen HSCs in physiological conditions, we have characterized HSCs in the spleen as compared with those in the BM. BM and spleen cells were obtained from 8–10 week-old C57BL/6 mice. Competitive repopulation showed that the repopulating activity per 106 BM cells was significantly greater than that per 106 spleen cells (about 10-fold). Limiting analysis showed that the frequency of long-term repopulating cells in BM cells was significantly higher than that in spleen cells (about 10-fold). As a result, the mean activity per BM stem cell was similar to that per spleen stem cell. Similarly to BM, CD34-negative, c-Kit-positive, Sca-1-positive, lineage markers-negative (CD34−KSL) cells were highly enriched in HSCs in the spleen. The frequency of CD34−KSL cells in the spleen was significantly lower than that in the BM. These data indicate that functionally equivalent HSCs exist in the spleen but at a low frequency. Data from single cell-transplantation supported this notion. The proportion of pyronin Y-negative G0 cells among BM CD34−KSL cells was greater than that among spleen CD34−KSL cells at any one time. BrdU-uptake analysis showed that spleen CD34− KSL cells were cycling more rapidly than BM CD34−KSL cells. These data suggest that spleen HSCs contribute to hematopoiesis to some extent under physiological conditions. BM and spleen HSCs may be interchangeable via the circulation. When BM HSCs are in the spleen, they are possibly under the control of spleen niches different from BM niches.
Stellenwert der Autopsie bei Patienten mit Kopf-Halstumoren (2012)

The study confirms the global trend of a decline in autopsy numbers in the last 3 decades. However, as an important instrument of quality assurance autopsies continue to play an essential and indispensable role in medical research.
pH-dependent fluorescence of merocyanine-eosin-labeled water-soluble polymers (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTpH-dependent fluorescence of merocyanine-eosin-labeled water-soluble polymersPing Yuan and David R. WaltCite this: Macromolecules 1990, 23, 21, 4611–4615Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October 1990https://pubs.acs.org/doi/10.1021/ma00223a019https://doi.org/10.1021/ma00223a019research-articleACS PublicationsRequest reuse permissionsArticle Views248Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Environmental stimuli and intestinal stem cell behavior (2012)

Comment on: Wong VWY, et al. Nat Cell Biol 2012; 14:401-8.
Applications of laser induced breakdown spectroscopy (LIBS) to international safeguards (2011)

Abstract Not Provided
A compact and low-loss GeSn electroabsorption modulator using vertical multimode interference for mid-infrared Ge-on-Si platform (2017)

A novel GeSn electroabsorption modulator using vertical multimode interference is proposed for mid-infrared photonics. The size of the proposed device is 1/3 with lower loss and larger extinction ratio compared with conventional structure.
A Signal Processing Approach for Cyber Data Classification with Deep Neural Networks (2015)

Recent cyber security events have demonstrated the need for algorithms that adapt to the rapidly evolving threat landscape of complex network systems. In particular, human analysts often fail to identify data exfiltration when it is encrypted or disguised as innocuous data. Signature-based approaches for identifying data types are easily fooled and analysts can only investigate a small fraction of network events. However, neural networks can learn to identify subtle patterns in a suitably chosen input space. To this end, we have developed a signal processing approach for classifying data files which readily adapts to new data formats. We evaluate the performance for three input spaces consisting of the power spectral density, byte probability distribution and sliding-window entropy of the byte sequence in a file. By combining all three, we trained a deep neural network to discriminate amongst nine common data types found on the Internet with 97.4% accuracy.
Exponentially-modulated filter bank transmultiplexer with fine-coarse adaptive filtering (2008)

In this paper we explore filter bank based multicarrier transmission, which has received increasing interest also in wireless communications system development as an alternative to the DFT-based OFDM technique. The odd-stacked low delay exponentially-modulated filter bank (EMFB) transmultiplexer is described. The subfilter biorthogonality condition is distorted in practical transmission channels and we use oversampled (by factor of two) per-subband equalization to recover the data symbols. The fine-coarse normalized least mean square (LMS) algorithm is applied with EMFB-specific modifications. The adaptation speed of the fine-subequalizers are further improved with simple re-initialization procedure. Numerical studies exhibit fast convergence and relatively small residual error in semiblind, decision-directed operation mode.