gebhart/patrepeval huggingface dataset:
Pt- and TCO-Free Flexible Cathode for DSSC from Highly Conducting and Flexible PEDOT Paper Prepared via in Situ Interfacial Polymerization (2015)

Here, we report the preparation of a flexible, free-standing, Pt- and TCO-free counter electrode in dye-sensitized solar cell (DSSC)-derived from polyethylenedioxythiophene (PEDOT)-impregnated cellulose paper. The synthetic strategy of making the thin flexible PEDOT paper is simple and scalable, which can be achieved via in situ polymerization all through a roll coating technique. The very low sheet resistance (4 Ω/□) obtained from a film of 40 μm thick PEDOT paper (PEDOT-p-5) is found to be superior to the conventional fluorine-doped tin oxide (FTO) substrate. The high conductivity (357 S/cm) displayed by PEDOT-p-5 is observed to be stable under ambient conditions as well as flexible and bending conditions. With all of these features in place, we could develop an efficient Pt- and TCO-free flexible counter electrode from PEDOT-p-5 for DSSC applications. The catalytic activity toward the tri-iodide reduction of the flexible electrode is analyzed by adopting various electrochemical methodologies. PEDOT-p-5 is found to display higher exchange current density (7.12 mA/cm(2)) and low charge transfer resistance (4.6 Ω) compared to the benchmark Pt-coated FTO glass (2.40 mA/cm(2) and 9.4 Ω, respectively). Further, a DSSC fabricated using PEDOT-p-5 as the counter electrode displays a comparable efficiency of 6.1% relative to 6.9% delivered by a system based on Pt/FTO as the counter electrode.
Real-Time Genomic Surveillance for SARS-CoV-2 Variants of Concern, Uruguay (2021)

We developed a genomic surveillance program for real-time monitoring of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in Uruguay. We report on a PCR method for SARS-CoV-2 VOCs, the surveillance workflow, and multiple independent introductions and community transmission of the SARS-CoV-2 P.1 VOC in Uruguay.
Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198 (2008)

Clinical studies using the microtubule-targeting agent 2-methoxyestradiol (2ME2; Panzem) in cancer patients show that treatment is associated with clinical benefit, including prolonged stable disease, complete and partial responses, and an excellent safety profile. Studies have shown that 2ME2 is metabolized by conjugation at positions 3 and 17 and oxidation at position 17. To define structure-activity relationships for these positions of 2ME2 and to generate metabolically stable analogues with improved anti-tubulin properties, a series of analogues was generated and three lead analogues were selected, ENMD-1198, ENMD-1200, and ENMD-1237. These molecules showed improved metabolic stability with >65% remaining after 2-h incubation with hepatocytes. Pharmacokinetic studies showed that oral administration of the compounds resulted in increased plasma levels compared with 2ME2. All three analogues bind the colchicine binding site of tubulin, induce G(2)-M cell cycle arrest and apoptosis, and reduce hypoxia-inducible factor-1alpha levels. ENMD-1198 and ENMD-1200 showed improved in vitro antiproliferative activities. Significant reductions in tumor volumes compared with vehicle-treated mice were observed in an orthotopic breast carcinoma (MDA-MB-231) xenograft model following daily oral treatment with all compounds (ANOVA, P < 0.05). Significantly improved median survival time was observed with ENMD-1198 and ENMD-1237 (200 mg/kg/d) in a Lewis lung carcinoma metastatic model (P < 0.05). In both tumor models, the high-dose group of ENMD-1198 showed antitumor activity equivalent to that of cyclophosphamide. ENMD-1198 was selected as the lead molecule in this analogue series and is currently in a phase I clinical trial in patients with refractory solid tumors.
Characterization of the Gene Encoding Human Sarcolipin (SLN), a Proteolipid Associated with SERCA1: Absence of Structural Mutations in Five Patients with Brody Disease (1997)

Sarcolipin (SLN) is a low-molecular-weight protein that copurifies with the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+ ATPase (SERCA1). Genomic DNA and cDNA encoding human sarcolipin (SLN) were isolated and characterized and the SLN gene was mapped to chromosome 11q22-q23. Human, rabbit, and mouse cDNAs encode a protein of 31 amino acids. Homology of SLN with phospholamban (PLN) suggests that the first 7 hydrophilic amino acids are cytoplasmic, the next 19 hydrophobic amino acids form a single transmembrane helix, and the last 5 hydrophilic amino acids are lumenal. The cytoplasmic and transmembrane sequences are not well conserved among the three species, but the lumenal sequence is highly conserved. Like SERCA1, SLN is highly expressed in rabbit fast-twitch skeletal muscle, but it is expressed to a lower extent in slow-twitch muscle and to an even lower extent in cardiac muscle, where SERCA2a and PLN are highly expressed. It is expressed in only trace amounts in pancreas and prostate. SLN and PLN genes resemble each other in having two small exons, with their entire coding sequences lying in exon 2 and a large intron separating the two segments. Brody disease is an inherited disorder of skeletal muscle function, characterized by exercise-induced impairment of muscle relaxation. Mutations in the ATP2A1 gene encoding SERCA1 have been associated with the autosomal recessive inheritance of Brody disease in three families, but not with autosomal dominant inheritance of the disease. A search for mutations in the SLN gene in five Brody families, four of which were not linked to ATP2A1, did not reveal any alterations in coding, splice junction or promoter sequences. The homozygous deletion of C438 in the coding sequence of ATP2A1 in Brody disease family 3, leading to a frameshift and truncation following Pro147 in SERCA1, is the fourth ATP2A1 mutation to be associated with autosomal recessive Brody disease.
Isa: Intuit Smart Agent, A Neural-Based Agent-Assist Chatbot (2018)

Hiring seasonal workers in call centers to provide customer service is a common practice in B2C companies. The quality of service delivered by both contracting and employee customer service agents depends heavily on the domain knowledge available to them. When observing the internal group messaging channels used by agents, we found that similar questions are often asked repetitively by different agents, especially from less experienced ones. The goal of our work is to leverage the promising advances in conversational AI to provide a chatbot-like mechanism for assisting agents in promptly resolving a customer's issue. In this paper, we develop a neural-based conversational solution that employs BiLSTM with attention mechanism and demonstrate how our system boosts the effectiveness of customer support agents. In addition, we discuss the design principles and the necessary considerations for our system. We then demonstrate how our system, named "Isa" (Intuit Smart Agent), can help customer service agents provide a high-quality customer experience by reducing customer wait time and by applying the knowledge accumulated from customer interactions in future applications.
Tumor targeting and therapeutic assessments of RNA nanoparticles carrying α9-nAChR aptamer and anti-miR-21 in triple-negative breast cancers (2023)

Triple-negative breast cancer (TNBC) is highly aggressive with a poor prognosis because of a lack of cell markers as drug targets. α9-Nicotinic acetylcholine receptor (nAChR) is expressed abundantly in TNBC; thus, it is a valuable biomarker for TNBC detection and treatment. In this study, we utilized thermodynamically stable three-way junction (3WJ) packaging RNA (pRNA) as the core to construct RNA nanoparticles with an α9-nAChR RNA aptamer as a targeting ligand and an anti-microRNA-21 (miR-21) as a therapeutic module. We compared the configuration of the two RNA nanoparticles and found that 3WJ-B-α9-nAChR-aptamer fluorescent RNA nanoparticles (3WJ-B-α9-apt-Alexa) exhibited better specificity for α9-nAChR in TNBC cells compared with 3WJ-C-α9-nAChR. Furthermore, 3WJ-B-α9-apt-Alexa bound more efficiently to TNBC patient-derived xenograft (PDX) tumors than 3WJ fluorescent RNA nanoparticles (3WJ-Alexa) with little or no accumulation in healthy organs after systemic injection in mice. Moreover, 3WJ-B-α9-nAChR-aptamer RNA nanoparticles carrying anti-miR-21 (3WJ-B-α9-apt-anti-miR-21) significantly suppressed TNBC-PDX tumor growth and induced cell apoptosis because of reduced miR-21 gene expression and upregulated the phosphatase and tensin homolog (PTEN) and programmed cell death 4 (PDCD4) proteins. In addition, no pathological changes were detected upon toxicity examination of treated mice. In conclusion, the 3WJ-B-α9-nAChR-aptamer RNA nanoparticles established in this study efficiently deliver therapeutic anti-miR-21, indicating their potential as a novel TNBC therapy.
Theoretical prediction of a charge-transfer phase transition (2018)

Phase transition materials are attractive from the viewpoints of basic science as well as practical applications. For example, optical phase transition materials are used for optical recording media. If a phase transition in condensed matter could be predicted or designed prior to synthesizing, the development of phase transition materials will be accelerated. Herein we show a logical strategy for designing a phase transition accompanying a thermal hysteresis loop. Combining first-principles phonon mode calculations and statistical thermodynamic calculations considering cooperative interaction predicts a charge-transfer phase transition between the A-B and A<sup>+</sup>-B<sup>-</sup> phases. As an example, we demonstrate the charge-transfer phase transition on rubidium manganese hexacyanoferrate. The predicted phase transition temperature and the thermal hysteresis loop agree well with the experimental results. This approach will contribute to the rapid development of yet undiscovered phase transition materials.
Relative contribution of preload and afterload to the reduction in cardiac output caused by nitric oxide synthase inhibition with L-NG-methylarginine hydrochloride 546C88 (2000)

Differential CO responses to phenylephrine and L-NMMA were primarily attributable to changes in preload. Variable venular vs. arteriolar constrictor effects must be considered when evaluating the integrated cardiovascular response to a vasoactive agent.
Homotypic and heterotypic immune responses to Omicron variant in immunocompromised patients in diverse clinical settings (2022)

Immunocompromised patients are predisposed to severe COVID-19. Here we compare homotypic and heterotypic humoral and cellular immune responses to Omicron BA.1 in organ transplant patients across a diverse clinical spectrum. We perform variant-specific pseudovirus neutralization assays for D614G, and Omicron-BA.1, -BA.2, and Delta variants. We also measure poly-and monofunctional T-cell responses to BA.1 and ancestral SARS-CoV-2 peptide pools. We identify that partially or fully-vaccinated transplant recipients after infection with Omicron BA.1 have the greatest BA.1 neutralizing antibody and BA.1-specific polyfunctional CD4<sup>+</sup> and CD8<sup>+</sup> T-cell responses, with potent cross-neutralization against BA.2. In these patients, the magnitude of the BA.1-directed response is comparable to immunocompetent triple-vaccinated controls. A subset of patients with pre-Omicron infection have heterotypic responses to BA.1 and BA.2, whereas uninfected transplant patients with three doses of vaccine demonstrate the weakest comparative responses. These results have implications for risk of infection, re-infection, and disease severity among immune compromised hosts with Omicron infection.
NeuroAnimator (1998)

Animation through the numerical simulation of physics- based graphics models offers unsurpassed realism, but it can be computationally demanding. Likewise, the search for controllers that enable physics-based models to produce desired animations usually entails formidable computational cost. This paper demon- strates the possibility of replacing the numerical simulation and control of dynamic models with a dramatically more efficient al- ternative. In particular, we propose the NeuroAnimator, a novel ap- proach to creating physically realistic animation that exploits neu- ral networks. NeuroAnimators are automatically trained off-line to emulate physical dynamics through the observation of physics- based models in action. Depending on the model, its neural net- work emulator can yield physically realistic animation one or two orders of magnitude faster than conventional numerical simulation. Furthermore, by exploiting the network structure of the NeuroAni- mator, we introduce a fast algorithm for learning controllers that en- ables either physics-based models or their neural network emulators to synthesize motions satisfying prescribed animation goals. We demonstrate NeuroAnimators for a variety of physics-based mod- els.
Multiphoton EUV photonics: Demonstration of quasi phase matching at short wavelengths (2002)

We present the first demonstration of quasi-phase-matched frequency conversion of laser light into the extreme-ultraviolet (EUV) region of the spectrum. Using a modulated hollow-core waveguide to periodically vary the intensity of the light driving the conversion process, we efficiently generate EUV light even in the presence of substantial ionization of the gas that would otherwise prevent buildup of the signal. This results in efficient generation of substantially higher harmonic photon energies than are otherwise possible. The periodic structure modulates the generation of high harmonics and restricts HHG to regions with favorable constructive interference. We also show that under the correct conditions the periodic structure may allow for the generation of isolated attosecond pulses, using easily-obtainable driving pulses of ~25 fs duration. This work overcomes a critical challenge in implementing useful coherent EUV sources at wavelengths of interest to advanced lithography, and for high-resolution imaging applications.
Effects of Semiconductor Thickness on Poly-Crystalline Silicon Thin Film Transistors (1996)

The effects of semiconductor thickness on poly-crystalline silicon (poly-Si) thin film transistors (TFTs) are studied. The small value of the threshold voltage ( V th ) appearing in thin film can improve the electrical properties of the corresponding TFTs. However, thin poly-Si film generally consists of small grains and contains many defects. When the film is extremely thin, it contains voids and it is in a separate island-like state. As a result, the extremely thin film possesses very many traps, which prevent the V th value from further decreasing. The way that thickness affects film quality differs according to how that film was prepared. Therefore, different TFT fabrication methods make the optimum semiconductor thickness different.
Safety and Immunogenicity of H1/IC31®, an Adjuvanted TB Subunit Vaccine, in HIV-Infected Adults with CD4+ Lymphocyte Counts Greater than 350 cells/mm3: A Phase II, Multi-Centre, Double-Blind, Randomized, Placebo-Controlled Trial (2014)

Pan African Clinical Trials Registry (PACTR) PACTR201105000289276.
Synthesis and Characterization of a Library of In‐Situ Curing, Nonswelling Ethoxylated Polyol Thiol‐ene Hydrogels for Tailorable Macromolecule Delivery (2014)

A transesterfication reaction is used to synthesize tri-thiol-functionalized-ethoxylated polyols that are combined with polyethylene glycol diacrylates to form a biodegradable hydrogel library. Hydrogels display nonswelling equilibration and offer temporal control over material degradation and the release of biomolecules. The demonstrated in vitro biocompatibility makes this a versatile platform that can be used for local drug delivery to volume-constrained anatomical sites.
A Smart, Mapping, Charting and Geodesy Control Generator. Phase 2 (1988)

Abstract : The real-time automated registration of multi-sensor imagery begins with the generation of control information. A specific application may require the registration of newly acquired data to an existing spatial database (absolute registration), or to other images of a series (relative registration). This study examines the feasibility and upper-level design of a system capable of providing the control information required for a range of image registration tasks and image types. In general, the control generator we suggest will be guided by a spatial database maintaining information about the feature content of the area of interest. A rule based query generator will extract candidate ground control optimized for the particular image type and geometry at hand.
New instrument for circular dichroism measurements in the vacuum ultraviolet (1977)

A new instrument is described for measurements of circular dichrosim (CD) in the vacuum ultraviolet region. A reflecting biotite plate is used as a linear polarizer and enables us to extend the CD measurements to about 1300Å. The CD spectra of d-camphor and of 3-methyl cyclopentene are presented.
Room-Temperature Synthesis of (LiMo3Se3)n and the Determination of the Relative Reduction Potential of tert-Butyllithium (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRoom-Temperature Synthesis of (LiMo3Se3)n and the Determination of the Relative Reduction Potential of tert-ButyllithiumJosh H. Golden, Francis J. DiSalvo, and Jean M. J. FrechetCite this: Chem. Mater. 1994, 6, 6, 844–849Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/cm00042a024https://doi.org/10.1021/cm00042a024research-articleACS PublicationsRequest reuse permissionsArticle Views475Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Automatic Impedance Matching of an Active Helical Antenna Near a Human Operator (2003)

This paper, presents an automatic impedance matching technique for normal mode helical antenna technique for a normal mode helical antenna near a human operator in the 150 MHz band. The helical antenna incorporating varactor diodes for changing impedance maintains a good matching condition regardless of the distance between the helical antenna and the operator. This eliminates a power loss caused by the impedance mismatch due to the human body. The technique makes use of the steepest gradient algorithm that can achieve an adaptive control algorithm of the impedance condition.
Improved vertically integrated resonant tunneling diodes (2003)

A lumped-element circuit model is developed for vertically integrated resonant tunneling diodes (RTDs), assuming that the individual RTDs behave as independent circuit elements in vertically integrated RTDs. The limit of this model is determined and the transition between incoherent and coherent transport is observed by systematic variation of separation layer thickness between diodes. The limit of applicability of this model is determined to be devices with 500 AA separation for 10/sup 18/ cm/sup -3/ doping. High current density is identified as a critical parameter for high-speed operation, and a peak current density of 2.5*10/sup 4/ A/cm/sup 2/ was achieved with little degradation in the peak to valley ratio by using thin barriers. Approaches for further improvement are suggested.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
China’s Growing Influence on Asian Financial Markets (2016)

This paper finds that financial spillovers from China to regional markets are on the rise. The main transmission channel appears to be trade linkages, although direct financial linkages are playing an increasing role. Without an impact on global risk premiums, China’s influence on regional markets is not yet to the level of the United States, but comparable to that of Japan. If China-related shocks are coupled with a rise in global risk premiums, as in August 2015 and January 2016, spillovers to the region could be significantly larger. Over the medium term, China’s financial spillovers could rise further with tighter financial linkages with the region, including through the ongoing internationalization of the renminbi and China’s capital account liberalization.
N2O Plasma Treatment Suppressed Temperature-dependent Point Defects Formation with Amorphous Indium-Gallium-Zinc-Oxide Thin Film Transistors (2013)

The abnormal sub-threshold leakage current is observed at high temperature in amorphous Indium-Gallium-Zinc-Oxide Thin Film Transistors (a-IGZO TFTs). To confirm this phenomenon dependence of the defects of a-IGZO active layer, the paper proposes the devices with N2O plasma treatment at a-IGZO film. This phenomenon only appears in the as-fabricated device, but not in the device with N2O plasma treatment, which is experimentally verified. N2O plasma treatment at a-IGZO TFTs enhances the thin film bonding strength which could suppress the formation of temperature-dependent point defects. The point defects could be generated from oxygen atoms have left their original sites above 400K. The N2O plasma treatment devices have better stability performance than as-fabricated devices. The results suggested that the density of point states for a-IGZO TFTs with N2O plasma treatment is much lower than that as-fabricated. The N2O plasma repairs the point defect to suppress temperature-dependent sub-threshold leakage current.
Is IL-6 capable to modify chondrocyte metabolism ? (1996)

peer reviewed
Potential impact of host immunity on malaria treatment outcome in Tanzanian children infected with Plasmodium falciparum (2007)

These findings suggest that GLURP-specific IgG antibodies in this setting contribute to clearance of drug-resistant infections and support the hypothesis that acquired immunity enhances the clinical efficacy of drug therapy. The results should be confirmed in larger scale with greater sample size and with variation in transmission intensity.
Treatment of Panic-Like Attacks with a Long-Acting Analogue of Somatostatin (1990)

Psychiatric evaluations were completed on four patients who were treated for "idiopathic flushing" with a long-acting analogue of somatostatin. All four patients had symptom profiles consistent with a diagnosis of panic disorder. All four experienced clinically significant relief from panic-like attacks while on the experimental medication. These findings suggest a possible role for somatostatin in the pathophysiology and treatment of panic disorder.