gebhart/patrepeval huggingface dataset:
Mixing effects of Ar-H/sub 2/ on the plasma characteristics of non-transferred DC plasma torches in the practical geometries (1995)

Summary form only given. Non-transferred DC plasma torches have been widely used as clean heat sources for material processings such as plasma spraying and synthesis. High enthalpy and high-speed plasma flames have given good processing efficiencies in the practical thermal plasma applications, especially in the plasma spray coating systems. Experiments indicate that an addition of hydrogen gas, which has a high specific heat and a low plasma density, to a primary argon gas greatly affects the arc power and plasma characteristics. In this study, mixing effects of Ar-H/sub 2/ on plasma characteristics in the non-transferred DC plasma torches at atmospheric condition are investigated by analyzing the voltage-current characteristics of are discharge and the distributions of plasma flow field. Typical assumptions of steady state, axisymmetry, local thermodynamic equilibrium (LTE) and optically thin plasma are adopted in a 2-D magnetohydrodynamic (MHD) modeling of thermal plasma with a special treatment of electrical conductivity at low temperature. In order to reflect the geometrical shapes of the torch, the numerical calculations are performed in the body-fitted nonorthogonal coordinate system with covariant velocity components using Karki's (1986) modified SIMPLER algorithm.
Seroquel® (Quetiapine Hemifumarate) (2010)

This chapter contains sections titled: Seroquel® and the Antipsychotic Market Synthesis of dibenzo[b,f][1,4]thiazepin-11(10H)-one (2) Quetiapine Hemifumarate from dibenzo[b,f][1,4]thiazepin-11(10H)-one (2) Alternative Methods for Constructing the Amidine Link of Quetiapine (1) Hemifumarate Constructing the Piperazine of Quetiapine (1) Hemifumarate Meeting Specifications: Recrystallizaton of Quetiapine (1) Free Base and Polymorphs of Quetiapine (1) Hemifumarate Trade Secrets and the Continuing Refinement of Analytical Methods The Best Process Available Today Structures Searched References
Optical Interposer Technology using Buried Vertical-Cavity Surface-Emitting Laser Chip and Tapered Through-Silicon Via for High-Speed Chip-to-Chip Optical Interconnection (2009)

A novel optical interposer with optical interconnections is proposed for integrating three-dimensional (3D) LSI chips on this interposer. Vertical-cavity surface-emitting laser diode (VCSEL) chips and photo diode (PD) chips are buried in the optical interposer with polymeric optical waveguides. The VCSEL is 0.25 mm in width, 0.35 mm in length, and 0.15 mm in height. We realize precise passive alignment between the optical waveguides and the VCSEL/PD chips using two-step alignment processes consisting of cavity-assisted positioning and the subsequent surface-tension-powered self-assembly with a molten solder. In addition, we demonstrate the basic operation of the buried VCSEL chips in the optical interposer through tapered through-silicon vias (TSVs). The tapered TSVs are successfully formed by copper electroplating and are 64 µm in top width, 34 µm in bottom width, and 168 µm in length.
ClusterFetch: A Lightweight Prefetcher for Intensive Disk Reads (2017)

By overlapping disk accesses with computation-intensive operations, prefetching can reduce delays in launching an application and in loading significant amounts of data while the application is running. The key to effective prefetching is making the tradeoff between the mining accuracy of selecting relevant blocks, and the time to decide those blocks. To address this problem, we propose a new prefetcher called ClusterFetch. In its learning mode, ClusterFetch detects periods of intensive disk accesses by monitoring the speed at which read requests are queued; it re-organizes these reads and locates the file opened by the application just before each such period. During subsequent runs of the same application, ClusterFetch prefetches the data associated with the opening of a “trigger” file. Our experimental results show that ClusterFetch implemented in Linux can reduce the application launch time by up to 41.3 percent and the loading time by up to 38.2 percent, while taking up less than 200 KB of main memory.
Performance evaluation of symbol synchronization in OFDM systems over impulsive noisy channels (2005)

The aim of this paper is to investigate the effects of impulsive noise on the performance of the maximum likelihood symbol synchronization (MLSS) algorithm in OFDM systems. Limitations of the MLSS algorithm are shown. Simulations results of the timing offset mean squared error (MSE) in static and mobile channels are considered. Ideas to enhance the performance of the algorithm in these environments are also proposed.
L’hydrogène bioinspiré : l’énergie de demain ? Un film et un débat (2011)

Les socits modernes sont de plus en plus confrontes des enjeux d'ordre scientifique dont la complexit croissante trouble les citoyens et rend difficiles les arbitrages et les dcisions politiques.
Sperm GIRK2-Containing K+Inward Rectifying Channels Participate in Sperm Capacitation and Fertilization (2011)

The GIRK2-containing inward-rectifying K(+) ion channels have been implicated in mammalian spermatogenesis. While the Girk2 null mice are fertile, the male weaver transgenic mice carrying a gain-of-function mutation in the Girk2 gene are infertile. To establish the exact period of spermatogenesis affected by this mutation, we performed StaPut isolation and morphological characterization of the germ cells present in the weaver testis. Germ cells representing all periods of spermatogenesis were identified. However, no spermatozoa were present, suggesting that this mutation only affected the haploid phase of spermatogenesis. Real-time PCR studies performed on StaPut purified germ cells from wild-type mice indicated that the Girk2 transcripts were exclusively expressed in spermatids. Immunofluorescence studies of mouse and boar spermatids/spermatozoa localized the GIRK2 K(+) containing channels to the acrosomal region of the sperm plasma membrane. During porcine in vitro fertilization (IVF), GIRK2-containing channels remained associated with the acrosomal shroud following zona-induced acrosome reaction. Fertilization was blocked by tertiapin-Q (TQ), a specific inhibitor of GIRK channels, and by anti-GIRK2 antibodies. Altogether, studies in two different mammalian species point to a conserved mechanism by which the GIRK2 inward-rectifying K(+) ion channels support sperm function during fertilization.
O MAS NMR Correlation Spectroscopy at High Magnetic Fields (2017)

The structure of two protected amino acids, FMOC-l-leucine and FMOC-l-valine, and a dipeptide, N-acetyl-l-valyl-l-leucine (N-Ac-VL), were studied via one- and two-dimensional solid-state nuclear magnetic resonance (NMR) spectroscopy. Utilizing ¹⁷O magic-angle spinning (MAS) NMR at multiple magnetic fields (17.6–35.2 T/750–1500 MHz for 1H) the ¹⁷O quadrupolar and chemical shift parameters were determined for the two oxygen sites of each FMOC-protected amino acids and the three distinct oxygen environments of the dipeptide. The one- and two-dimensional, ¹⁷O, ¹⁵N–¹⁷O, ¹³C–¹⁷O, and 1H–¹⁷O double-resonance correlation experiments performed on the uniformly ¹³C,¹⁵N and 70% ¹⁷O-labeled dipeptide prove the attainability of ¹⁷O as a probe for structure studies of biological systems. ¹⁵N–¹⁷O and ¹³C–¹⁷O distances were measured via one-dimensional REAPDOR and ZF-TEDOR experimental buildup curves and determined to be within 15% of previously reported distances, thus demonstrating the use of ¹⁷O NMR to quantitate interatomic distances in a fully labeled dipeptide. Through-space hydrogen bonding of N-Ac-VL was investigated by a two-dimensional ¹H-detected ¹⁷O R³-R-INEPT experiment, furthering the importance of ¹⁷O for studies of structure in biomolecular solids.
Analytical Determination of Capacitance and Conductance Coupling Matrices for Assisting the Design of Capacitively Coupled Planar Power Conversion Apparatuses (2020)

The emergence of higher performance capacitively coupled power conversion systems, for example, electrostatic rotating machines and capacitive power transfer, prompts the need for tools to assist the design and optimization process. Finite-element analysis (FEA) has been the default method to analyze these systems, due to the complexity of solving the electrostatic field in a multipotential–multimaterial structure. However, the variational and discretized nature of FEA introduces a bottleneck in the speed of the optimization process. This article presents an analytical approach that is capable of solving problems with nonzero electrode thickness and multiple materials, to evaluate the capacitance coupling matrix in planar power conversion apparatuses as an alternative to FEA. The duality between the electric displacement and the current fields allows this method to easily compute the conductance matrix as well, yielding effective loss models. When benchmarked against FEA for a synchronous electrostatic machine, this proposed analytical solution shows less than 2% relative error and takes merely 1 s to complete the computation for each set of design parameters, whereas the FEA takes 9 h.
Ageing properties and polymer/fuel interactions of polyamide 12 exposed to (bio)diesel at high temperature (2018)

Abstract Biodiesel derived from oil crops and animal fats has been developed as a promising carbon-neutral alternative to petroleum fuels in the transport sector, but the compatibility between biodiesel/petroleum diesel and polymer components in the automotive fuel system has not been free from controversy. In this present study, the degradation of polyamide 12 (PA12), one of the most common polymers used in vehicle fuel systems, has been investigated after exposure to petroleum diesel, biodiesel and a mixture of these (20 vol.% of biodiesel/80 vol.% petroleum diesel). Fuel sorption kinetics, glass transition temperature data and mechanical properties all showed that the fuels plasticized the PA12. In addition, monomers and oligomers were extracted from PA12 by the fuels. The long-term exposure led to oxidation and an annealing-induced increase in crystallinity of the polymer. The plasticization, oxidation and annealing effects were combined with the tensile mechanical properties to assess the overall degree of ageing and degradation of the PA12 material. The fuel-polymer interactions and ageing mechanisms, demonstrated here at high temperature for PA12, are 'generic' in the sense that they are also expected to occur, to various degrees, with many other polymers and they indicate that care should be taken when choosing polymers in applications where they will be exposed to fuels at high temperature.
Insight into the Mechanisms of Cooperative Self-Assembly:  The “Sergeants-and-Soldiers” Principle of Chiral and Achiral C3-Symmetrical Discotic Triamides (2007)

On the basis of temperature-dependent UV-vis and circular dichroism (CD) spectroscopy measurements, we observed that C3-symmetrical discotic molecules, chiral (R)-1 and achiral 2, both self-assemble in a highly cooperative fashion. Chiral (R)-1 shows a higher degree of cooperativity, meaning it requires a larger nucleus before elongation sets in, as compared to achiral 2. Next to that, we investigated the mechanism of the "sergeants-and-soldiers" principle, where we found that the chiral sergeant (R)-1 strongly amplifies the preference in handedness of the mixed stacks of (R)-1 and 2. However, the elongation temperature and the degree of cooperativity are linearly dependent on both, at least in the regime above 4% of sergeant in the mixed system. Remarkably, we observed that at room temperature a fast exchange on the second time scale exists between molecules and stacks of sergeant (R)-1 and soldier 2, and that interconversion between M and P helices is fast at this temperature.
HR Transformation Technology (2016)

HR Transformation Technology is a complete, business-orientated guide to the planning, design and delivery of HR information systems. It spells out the full scope of the applications required to support HR shared services, centres of excellence and business partner roles and goes on to set out the step-by-step process for managing the delivery of a major HR information system project, and ensure it remains on schedule and on budget. HR Transformation Technology provides: ¢ An understanding of the role of IT in HR and the way in which it supports key elements such as the HR shared service centre and HR Business Partners; ¢ A clear picture of the features and benefits of the main types of HR IT application and an overview of what can commonly go wrong; ¢ The knowledge to build and communicate a definitive business case for the project; ¢ Details of the processes to be followed when defining what you need and selecting the partners who can deliver it. The book also provides up to date, practical examples of what other major organizations have achieved along with an invaluable top ten list of dos and don'ts for the HR systems project manager. This book is indispensable for anyone with responsibility for delivering HR systems.
Linear space-variant optical processing of 1-D signals (1977)

In the past, most optical data processing systems have been restricted to performing linear space-invariant operations. However, a wide class of interesting data processing operations require linear space-variant filtering. Three methods for performing linear space-variant processing of 1-D inputs are described. Experimental results obtained with all three systems are presented, and their relative advantages and disadvantages are discussed.
Efficient Synthesis of 13C,15N-Labeled RNA Containing the Cap Structure m7GpppA (2000)

Studying the mechanism by which the cap structure performs its numerous biological roles in mRNA metabolism by NMR spectroscopy requires the large-scale production of isotopically labeled capped RNA. We present an efficient method for production of short RNA containing the cap structure m7GpppA, by combining chemical synthesis with enzymatic synthesis using a DNA primase. This method was employed to synthesize three capped RNA molecules, m7Gppp[13C,15N]A, m7Gppp[13C,15N]ACC, and m7GpppA[13C,15N]C[13C,15N]C, that contain selective 13C,15N-labeled adenosine or cytosine nucleotides. This selective labeling technique enabled us to obtain the chemical shift assignments of these oligonucleotides in complex with the eukaryotic translation initiation factor 4E (eIF4E). Furthermore, we were able to observed intermolecular NOE interactions between the RNA and protein.
A New Mouse Strain to Study Motoneurons in Pompe Disease (2020)

Pompe disease is a lysosomal storage disorder resulting from a deficiency in the lysosomal enzyme acid α‐glucosidase (GAA). The most severe form of the disease is associated with complete or near complete absence of functional GAA which results in cardiorespiratory failure and death within the first year of life. The only approved treatment for Pompe disease is human recombinant GAA (enzyme replacement therapy (ERT)) which improves overall survival rates but the recombinant protein does not reach the central nervous system. Respiratory impairment in Pompe disease has historically been attributed to muscle weakness but an accumulation of studies of Pompe patients and animal models indicate that motoneuron pathology is functionally relevant. In an effort to better understand the role of motoneurons in Pompe disease, we used breeding strategies to create a new mouse model with motoneuron histopathology features seen in Pompe disease while also allowing easy visualization of motoneurons via a fluorescent tag. Chat‐cre mice (Jackson) were crossed with Gaa −/− mice (Taconic). The resulting heterozygous strain were crossed with eYFP +/+ mice (courtesy Dr. Brian Harfe). Further breeding resulted in homozygous mice which were Chat‐cre +/+ /Gaa −/− /eYFP +/+ . These mice were then crossed to a Flox‐Gaa +/+ (Taconic) to create a heterozygous strain (Chat‐cre +/− /Gaa +/− /eYFP +/− /Flox‐Gaa +/− ). Further inbreeding produced mice that were Chat‐cre +/+ /Gaa +/− /eYFP +/+ /Flox‐Gaa +/+ . The intent of this final cross was to produce mice in which alpha motoneurons express eYFP but do not express GAA. Histological evaluation of the brainstem and spinal cord of these mice showed robust eYFP expression in the brainstem including the hypoglossal motor nucleus, nucleus ambiguous, and facial motor nucleus. In the cervical spinal cord, alpha motoneurons throughout the ventral horn also had robust fluorescence. This included putative phrenic motoneurons as determined based on location and size. The robust eYFP expression was restricted to motoneurons which indicates that motoneurons are Gaa −/− (based on the breeding scheme). Ongoing studies are evaluating GAA protein expression in peripheral tissues, glycogen accumulation in motoneurons, and also brainstem and spinal cord motoneuron loss over the lifespan. In addition, the eYFP signal in motoneurons will permit rigorous evaluation of motoneuron transduction efficacy in gene therapy experiments. Support or Funding Information 2R01HD052682‐11A1 (DDF/BJB)
Computational Analysis of Enhanced Magnetic Bioseparation in Microfluidic Systems with Flow-Invasive Magnetic Elements (2014)

A microfluidic design is proposed for realizing greatly enhanced separation of magnetically-labeled bioparticles using integrated soft-magnetic elements. The elements are fixed and intersect the carrier fluid (flow-invasive) with their length transverse to the flow. They are magnetized using a bias field to produce a particle capture force. Multiple stair-step elements are used to provide efficient capture throughout the entire flow channel. This is in contrast to conventional systems wherein the elements are integrated into the walls of the channel, which restricts efficient capture to limited regions of the channel due to the short range nature of the magnetic force. This severely limits the channel size and hence throughput. Flow-invasive elements overcome this limitation and enable microfluidic bioseparation systems with superior scalability. This enhanced functionality is quantified for the first time using a computational model that accounts for the dominant mechanisms of particle transport including fully-coupled particle-fluid momentum transfer.
Growth Behavior of Atomic-Layer-Deposited Pb(Zr,Ti)O[sub x] Thin Films on Planar Substrate and Three-Dimensional Hole Structures (2008)

Quaternary (PZT) films were deposited at by a combination of liquid-injection atomic layer deposition (ALD) of binary PbO, , and thin films. In preliminary work, binary films were deposited at by ALD. Two solutions of and dissolved in ethylcyclohexane (ECH) were prepared, and it was found that the solution provides a three-times-higher deposition rate for the films than the solution. We focused the study on the set of precursors which offers the highest degree of flexibility for adjusting the ratio in the PZT films: , , and dissolved in ECH, and water as the oxidant. This set of solutions contributed to increasing the ratio in the deposited PZT films to more than 0.2, which remained below 0.1 in the ALD-PZT using , , and . The ratio was further increased to 0.5 by modifying the sequence of the discrete-source gas pulses. A polarization–voltage hysteresis loop was observed for a thick PZT film deposited on a planar substrate after postannealing for crystallization. To assess the feasibility of ALD as a tool for coating three-dimensional (3D) structures uniformly, PZT films were deposited on submicrometer 3D structures. As-deposited amorphous PZT films as well as crystallized PZT films were both free of any gradient in the cation composition over the structure. The present work reports interesting interactions on stacking different binary-oxide layers by ALD and demonstrates why the multiprecursor ALD process is a promising approach for uniformly coating 3D nanostructures with complex oxide materials.
Microlaser pumped, engineerable bandwidth parametric chirped-pulse amplifier using electric-field-poled LiNbO/sub 3/ (1998)

Summary form only given. We have demonstrated the use of periodically poled LiNbO/sub 3/ as a practical diode-pumped parametric gain medium for ultrashort pulse amplification. The essential advantage is that a high single-pass gain is achievable without the need for regenerative or multiple-pass amplification. Uniquely, such an amplifier has engineerable optical properties, which potentially can provide extremely broad gain bandwidths suitable for amplification of few femtosecond pulses.
Requirements for Successful Adoption of a Glucose Measurement System Into a Hospital POC Program (2016)

Widespread and successful implementation of any glucose measurement system in a hospital point-of-care (POC) program requires a number of features in addition to accurate and reliable analytical performance. Such features include, but are not limited to, a system's glucose-hematocrit dependence, durability, information technology capabilities, and battery capacity and battery life. While the study of Ottiger et al in this issue supports the analytical accuracy and reliability of Bayer's CONTOUR XT® blood glucose monitoring system, the suitability of other features of this system for a hospital POC program remains to be established.
Radioiodination of BODIPY and its application to a nuclear and optical dual functional labeling agent for proteins and peptides (2017)

In molecular imaging research, the development of multimodal imaging probes has recently attracted much attention. In the present study, we prepared radioiodinated BODIPY and applied it as a nuclear and optical dual functional labeling agent for proteins and peptides. We designed and synthesized [<sup>125</sup>I]BODIPY with a N-hydroxysuccinimide (NHS) ester, and evaluated its utility as a nuclear and fluorescent dual labeling agent for proteins and peptides. In the radioiodination reaction of BODIPY-NHS with [<sup>125</sup>I]NaI, [<sup>125</sup>I]BODIPY-NHS was obtained at a 48% radiochemical yield. When we carried out the conjugation reaction of [<sup>125</sup>I]BODIPY-NHS with bovine serum albumin (BSA) and RGD (Arg-Gly-Asp) peptide as a model protein and peptide, respectively, [<sup>125</sup>I]BODIPY-BSA and [<sup>125</sup>I]BODIPY-RGD peptide were successfully prepared at 98 and 82% radiochemical yields, respectively. Furthermore, we prepared [<sup>123</sup>I]BODIPY-trastuzumab by this conjugation reaction and successfully applied it to single photon emission computed tomography (SPECT) imaging studies using tumor-bearing mice, suggesting that radioiodinated BODIPY-NHS serves as a dual functional labeling agent for proteins and peptides. Since iodine has various radioisotopes that can be used for SPECT and positron emission tomography (PET) imaging, biological research, and radiotherapy, the radioiodinated BODIPY may be extensively applicable from basic to clinical research.
Supplementary Figure S4 from USP9X Downregulation Renders Breast Cancer Cells Resistant to Tamoxifen (2023)

&lt;p&gt;Figure S4. Ingenuity Pathway enrichment and GO analysis of 1874 shUSP9X-affected genes not associated with estrogen induction. (A) Top canonical pathways (B) GO analyses for top enriched functions (top) and processes (bottom). FDR and p values are indicated.&lt;/p&gt;
ChemInform Abstract: The Synthesis of (‐)‐Anamarine (1987)

Abstract (XVII).
Capillary electrophoresis of DNA fragments in entangled polymer solutions: A study of separation variables (1992)

Abstract Capillary electrophoresis (CE) in entangled polymer solutions was studied using pBR322 DNA Hae III digest as a model sample. The influences of polymer nature, monomer chain length, and polymer concentration were investigated. The use of a novel polymer, galactomannan, as the entangled matrix for the separation of DNA fragments has been demonstrated.