gebhart/patrepeval huggingface dataset:
The Effect of Slug Frequency on Corrosion in High Pressure, Inclined Pipelines (1996)

Abstract The effect of inclination on flow regimes and individual flow characteristics has been studied and the subsequent effect on corrosion has also been examined. Experiments were carried out in high pressure. 10 cm diameter, inclinable flow loops using brine, one oil with water cuts of 100, 80, and 60%, using carbon dioxide gas at pressures up to 1.13 MPa and temperatures up to 90 C. When the pipe is inclined upwards, the stratified flow regime virtually disappears and slug flow dominates the flow regime map. In the film region between slugs, water layers at the bottom of the pipe were still found. Oil/water mixtures flow above the water layer. The slug frequency and Froude number change with increase in inclination. The slug frequency is higher for the inclined flows than horizontal flows at the same conditions. Further, near to the change of inclination, the slug frequency is almost double that found at distances 10-15 m along the inclined pipe. The Froude numbers of these slugs are similar to those found in horizontal flows. However, values as high as 17 have been recorded. These were not noted in horizontal flows and are very turbulent slugs with regions of severe wall shear forces at the slug front. The corrosion rate increased substantially as the slug frequency was increased to about 80 slugs per minute. Above this, there was little change in the corrosion rate. At a fixed slug frequency, the corrosion rates have been found to increase with an increase in Froude number, carbon dioxide partial pressure, and temperature.
Enantioselective Total Synthesis of (−)‐Minovincine in Nine Chemical Steps: An Approach to Ketone Activation in Cascade Catalysis (2013)

Dressed to the nines: The first enantioselective total synthesis of (-)-minovincine has been accomplished in nine chemical steps and 13 % overall yield. A novel, one-step Diels-Alder/β-elimination/conjugate addition organocascade sequence allowed rapid access to the central tetracyclic core in an asymmetric manner. Boc=tert-butoxycarbonyl, LG=leaving group, PMB=para-methoxybenzyl.
High Strength Bimodal Amphiphilic Conetworks for Immunoisolation Membranes: Synthesis, Characterization, and Properties (2015)

A strategy for the synthesis of new cross-linkable bimodal amphiphilic grafts (bAPGs) was developed. These grafts are of hydrophilic PDMAAm backbones carrying low (Mn ∼ 17 200 g/mol) and high (Mn ∼ 117 000 g/mol) molecular weight hydrophobic PDMS branches, each branch carrying a vinylsilyl end-group. The bAPGs were cross-linked by Karstedt catalyst to bimodal amphiphilic conetworks (bAPCNs) by the use of polyhydrosiloxane-co-PDMS as the cross-linker. Membranes prepared from bAPCNs exhibit mechanical properties surprisingly superior to earlier APCNs prepared with APGs with monomodal low molecular weight branches. Membrane bimodality controls surface morphology and topography by means of elastic wrinkling instability during film formation. Semipermeable bAPCN membranes with precisely controlled nanochannel dimensions were prepared so as to allow rapid insulin diffusion and prevent passage of IgG. bAPCN membranes were designed for immunoprotection of live pancreatic islets and are thus key components for a bioartificial pancreas.
Functional properties of LRRK2 mutations in Taiwanese Parkinson disease (2016)

Our study suggests that p.R1441H protein facilitates the formation of intracellular inclusions, compromises GTP hydrolysis by increasing its affinity for GTP, and reduces its interaction with ARHGEF7.
Solid State Synthesis and Characterization of Tin‐Based Low‐Dimensional Materials (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Supplementary Figures 1-10 from FTY720 (Fingolimod) Sensitizes Prostate Cancer Cells to Radiotherapy by Inhibition of Sphingosine Kinase-1 (2023)

Supplementary Figures 1-10 from FTY720 (Fingolimod) Sensitizes Prostate Cancer Cells to Radiotherapy by Inhibition of Sphingosine Kinase-1
Supplemental text - unmarked from Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells (2023)

&lt;p&gt;Supplemental text - unmarked&lt;/p&gt;
Miniaturised MIMO antenna array of two vertical monopoles embedded inside a planar decoupling network for the 2.4 GHz ISM band (2019)

This study introduces a fundamentally new approach to suppress mutual coupling among two closely‐spaced vertical monopole elements of a multiple‐input multiple‐output antenna array. The 40 × 40 × 1.27 mm decoupling and matching element consists of a single planar ring resonator acting as a stop‐band filter along with two tuning strips printed on an ungrounded substrate surrounding a two‐element co‐planar waveguide‐fed monopoles separated by 8 mm ( λ 0 /16) at 2.45 GHz. Measurements reveal 14.2% bandwidth centred at 2.395 GHz over which the decoupling is below 20 dB, and −10‐dB impedance bandwidth of 19.5% centred at 2.36 GHz. An improvement of 43 dB in isolation is observed at a frequency of 2.38 GHz. It is shown that the decoupled array provides a total realised gain of 1.69 dBi with excellent diversity performance as demonstrated by the low envelope correlation coefficient and improved link efficiency in highly‐correlated channel environments due to the spatially orthogonal 3D radiation patterns. The capacity offered by the decoupled array is enhanced by 50, 22, 18 and 12% at signal‐to‐noise ratios of 5, 20, 30, and 50 dB, respectively, as compared to the coupled array in an urban micro‐channel spatial model.
Resonant cavity enhancement of polycrystalline PbTe films for IR detectors on Si-ROICs (2011)

In this paper, we demonstrate high optical quantum efficiency (90%) resonant-cavity-enhanced mid-infrared photodetectors fabricated monolithically on a silicon platform. High quality photoconductive polycrystalline PbTe film is thermally evaporated, oxygen-sensitized at room temperature and acts as the infrared absorber. The cavity-enhanced detector operates in the critical coupling regime and shows a peak responsivity of 100 V/W at the resonant wavelength of 3.5 &mu;m, 13.4 times higher compared to blanket PbTe film of the same thickness. Detectivity as high as 0.72 × 10<sup>9</sup>cmHz<sup>1/2</sup>W<sup>1</sup> has been measured, comparable with commercial polycrystalline mid-infrared photodetectors. As low temperature processing (&lt; 160 &deg;C) is implemented in the entire fabrication process, our detector is promising for monolithic integration with Si readout integrated circuits.
Coalescence of Atomically Precise Clusters on Graphenic Surfaces (2014)

The interaction of ultrasmall metal clusters with surfaces of graphene is important for developing promising future applications of graphenic materials. In the experiment, chemically synthesized reduced graphene oxide (RGO) in water was mixed with Au25SR18 (where SR, SCH2CH2Ph, is a ligand protecting the cluster core) in tetrahydrofuran, and a completely new cluster, larger in mass, was formed at the liquid–liquid interface. Matrix assisted laser desorption ionization mass spectrometry of the product attached to RGO show that the peak due to Au25SR18 disappears gradually upon reaction and a single sharp peak referred to here as “135 ± 1 kDa cluster” appears. The composition of the new cluster is very close to the well-known magic cluster, Au144SR60 while the peak maximum is at Au135SR57. The formation of 35 ± 1 kDa cluster from the parent Au25 is proposed to be governed by the trapping of smaller clusters in a deep potential well generated at the graphene surface. We theoretically model the active role of the surface in stabilizing the large clusters. Our studies indicate a general mechanism of stabilization of clusters of precise size via the competition between the interfacial fluctuations and the energy scales of interaction of the clusters with the surface. The chemical transformation occurs at deformable surfaces at reduced particle densities which is in good agreement with the theoretical model. Transformations of this kind are important in controlled tuning of particles at graphenic surfaces.
D2D Assisted Beamforming for Coded Caching (2020)

Device-to-device (D2D) aided beamforming for coded caching is considered in a finite signal-to-noise ratio regime. A novel beamforming and resource allocation scheme is proposed where the local cache content exchange among nearby users is exploited. The transmission is split into two phases: local D2D content exchange and downlink transmission. In the D2D phase, users can autonomously share content with the adjacent users. The downlink phase utilizes multicast beamforming to simultaneously serve all users to fulfill the remaining content requests. A low complexity D2D-multicast mode selection algorithm is proposed with comparable performance to the optimal exhaustive search. We first explain the main procedure via one simple example and then present the general formulation. Furthermore, D2D transmission scenarios and conditions useful for minimizing the overall delivery time are identified. By exploiting the direct D2D exchange of file fragments, the common multicasting rate for delivering the remaining file fragments in the downlink phase is increased, providing greatly enhanced overall content delivery performance.
Immune Checkpoint Inhibitor-Induced Hypophysitis: Lessons Learnt from a Large Cancer Cohort (2021)

Immune checkpoint inhibitors (ICIs) can cause pituitary dysfunction due to hypophysitis. We aimed to characterize ICI-induced hypophysitis and examine its association with overall survival in this single-center retrospective cohort study of adult patients with cancer who received an ICI from January 1, 2012 through December 31, 2016. A total of 896 patients were identified who received ipilimumab alone (n=120); ipilimumab and nivolumab (n=50); ipilimumab before or after pembrolizumab (n=70); pembrolizumab alone (n=406); and nivolumab alone (n=250). Twenty-six patients (2.9%) developed hypophysitis after a median of 2.3 months. Median age at the start of ICI was 57.9 years and 54% were men. Hypophysitis occurred in 7.9% of patients receiving ipilimumab alone or in combination or sequence with a programmed cell death protein 1 inhibitor; 1.7% after pembrolizumab alone, never after nivolumab alone. Secondary adrenal insufficiency occurred in all hypophysitis cases. Use of ipilimumab alone or in combination was associated with pituitary enlargement on imaging and mass effects more frequently than pembrolizumab alone. Occurrence of hypophysitis was associated with improved overall survival by univariate analysis (median 50.7 vs 16.5 months; p=0.015) but this association was not observed in multivariable landmark survival analysis (HR for mortality 0.75; 95% CI 0.38 to 1.30; p=0.34) after adjusting for age, sex and malignancy type. To conclude, hypophysitis occurred most frequently after ipilimumab and manifested as anterior hypopituitarism affecting the corticotrophs more commonly than thyrotrophs and gonadotrophs. Mass effects and pituitary enlargement occurred more frequently in ipilimumab-induced hypophysitis. The association of hypophysitis with overall survival needs further investigation.
Highly reliable operation of strain-compensated0.98 µmInGaAs/InGaP/GaAs lasers with InGaAsP strained barriers for EDFAs (1995)

Highly reliable operation of 0.98 µm strain-compensated InGaAs/InGaAsP lasers is demonstrated for the first time with an estimated lifetime of 170 kh at 25°C. Moreover, we reveal that the degradation rates at 90°C and 80 mW output power are four times smaller than those of identical lasers with GaAs barriers.
High-acceleration linear drives: dimensioning and constraints relative to electromagnetic valves (2005)

In this paper, the feasibility of replacing a mechanical valve actuation system with an electromagnetic system is considered. Following a mechanical study conducted in order to determine both the power and consumption needs, two types of electromagnetic linear actuators are examined to evaluate their viability for the target application. The possibility of associating springs with linear actuators to fulfil the pertinent specifications are also discussed.
Stromal Cell–Derived Inducing Activity, Nurr1, and Signaling Molecules Synergistically Induce Dopaminergic Neurons from Mouse Embryonic Stem Cells (2006)

To induce differentiation of embryonic stem cells (ESCs) into specialized cell types for therapeutic purposes, it may be desirable to combine genetic manipulation and appropriate differentiation signals. We studied the induction of dopaminergic (DA) neurons from mouse ESCs by overexpressing the transcription factor Nurr1 and coculturing with PA6 stromal cells. Nurr1-expressing ESCs (N2 and N5) differentiated into a higher number of neurons (approximately twofold) than the naive ESCs (D3). In addition, N2/N5-derived cells contained a significantly higher proportion (>50%) of tyrosine hydroxylase (TH)+ neurons than D3 (<30%) and an even greater proportion of TH+ neurons (approximately 90%) when treated with the signaling molecules sonic hedgehog, fibroblast growth factor 8, and ascorbic acid. N2/N5-derived cells express much higher levels of DA markers (e.g., TH, dopamine transporter, aromatic amino acid decarboxylase, and G protein-regulated inwardly rectifying K+ channel 2) and produce and release a higher level of dopamine, compared with D3-derived cells. Furthermore, the majority of generated neurons exhibited electrophysiological properties characteristic of midbrain DA neurons. Finally, transplantation experiments showed efficient in vivo integration/generation of TH+ neurons after implantation into mouse striatum. Taken together, our results show that the combination of genetic manipulation(s) and in vitro cell differentiation conditions offers a reliable and effective induction of DA neurons from ESCs and may pave the way for future cell transplantation therapy in Parkinson's disease.
Efficient Management of Multiple Piconets in an MC-CDMA-Based UWB System (2008)

With multiple overlapped piconets, the IEEE 802.15.3 Medium Access Control (MAC) protocol uses a Parent/Child (P/C) or Parent/Neighbor (P/N) configuration to avoid inter-piconet interference. However, the throughput of a P/N or P/C configuration cannot exceed that of a single piconet. In the present paper we propose an efficient means of managing multiple piconets to cooperate with a Multi-Carrier Code Division Multiple Access (MC-CDMA) based UWB system. The proposed management approach uses an Intermediate Device (IDEV) to connect Piconet Coordinators (PNCs). A senior PNC adaptively arranges two simultaneous data transmission links with the proposed spreading matrices in each Channel Time Allocation (CTA) instead of a P/C or P/N configuration, which supports only a single link in each CTA. Simulation results demonstrate the proposed scheme can achieve a higher throughput with an acceptable compromise of link success probability in multiple overlapped piconets.
Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error (2016)

Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.
MIMOCommunication Systems (2003)

Abstract —MIMO technology is an emerging area that promises significant improvements in coverage and capacity of wireless networks. In this chapter, we review this rapidly developing technology. We present the key leverages of MIMO–array gain, diversity gain, multiplexing gain and interference reduction and provide insights into how these gains may be utilized to improve the quality of wireless communication. We introduce a simple MIMO channel model for flat fading conditions in an interference free environment and present previously derived capacity results for MIMO systems that hint to a significant capacity advantage. We discuss the broad goals of MIMO signaling (multiplexing vs diversity), the tradeoffs in receiver design for various signaling schemes and coding and modulation techniques for MIMO. Finally, we conclude with a list of emerging research areas in the field of MIMO communication systems.
Advances and Perspectives of Supercritical Fluid Technology (2013)

1 Dipartimento di Ingegneria Industriale, Universita di Salerno, Salerno, 84084 Fisciano, Italy 2 Departamento de Ingenieŕia Quimica, Universidad de Castilla-La Mancha, 13004 Ciudad Real, Spain 3 Department of Agricultural, Food &amp; Nutritional Sciences, University of Alberta, Edmonton, AB, Canada T6G 2P5 4Dipartimento di Ingegneria Chimica, Gestionale, Informatica, Meccanica, Universita di Palermo, 90128 Palermo, Italy
Towards collaborative support system for teamwork between robots and human in hazard incidents (2013)

Search and Rescue (SAR) missions for unexpected catastrophic incidents requires fast response and should provide safety especially that they lead to extreme exposure to risk of either potential victims or elements belonging to first responders team. New solutions based on robots and different techniques have been used to enhance the SAR missions in the last decade. This paper addresses a proposed solution that can be used to support collaborative teamwork between teams of robots and human in safety missions.
Crise urbaine et développement économique local en Grande-Bretagne : l'apport de la nouvelle gauche urbaine (1990)

Urban crisis and local economic development in Great Britain : the contribution of the new urban left In Great Britain, the inner city crisis and the dissatisfaction brought about by the management of the Labour governments of the 1960s and 1970s paved the way for the « new urban left ». Its originality is two-fold : it has invested and asserted itself in local politics, called « low politics » ; in addition it. has proposed a new model of local government management different from both the traditional Labour municipal model and that advocated by the conservative government. The example of the interventionist local economic development policies illustrates the originality and the scope of this new urban left. The interest of the British wage earning middle classes in the public sphere presents analogies with the French situation.
Enhanced Monocyte Response and Decreased Central Memory T Cells in Children with Invasive Staphylococcus aureus Infections (2009)

Staphylococcus aureus has emerged as a significant pathogen causing severe invasive disease in otherwise healthy people. Despite considerable advances in understanding the epidemiology, resistance mechanisms, and virulence factors produced by the bacteria, there is limited knowledge of the in vivo host immune response to acute, invasive S. aureus infections. Herein, we report that peripheral blood mononuclear cells from patients with severe S. aureus infections demonstrate a distinctive and robust gene expression profile which is validated in a distinct group of patients and on a different microarray platform. Application of a systems-wide modular analysis framework reveals significant over-expression of innate immunity genes and under-expression of genes related to adaptive immunity. Simultaneous flow cytometry analyses demonstrated marked alterations in immune cell numbers, with decreased central memory CD4 and CD8 T cells and increased numbers of monocytes. CD14+ monocyte numbers significantly correlated with the gene expression levels of genes related to the innate immune response. These results demonstrate the value of applying a systems biology approach that reveals the significant alterations in the components of circulating blood lymphocytes and monocytes in invasive S. aureus infections.
From User-Centered to Adoption-Centered Design (2015)

As we increasingly strive for scientific rigor and generalizability in HCI research, should we entertain any hope that by doing good science, our discoveries will eventually be more transferrable to industry? We present an in-depth case study of how an HCI research innovation goes through the process of transitioning from a university project to a revenue-generating startup financed by venture capital. The innovation is a novel contextual help system for the Web, and we reflect on the different methods used to evaluate it and how research insights endure attempted dissemination as a commercial product. Although the extent to which any innovation succeeds commercially depends on a number of factors like market forces, we found that our HCI innovation with user-centered origins was in a unique position to gain traction with customers and garner buy-in from investors. However, since end users were not the buyers of our product, a strong user-centered focus obfuscated other critical needs of the startup and pushed out perspectives of non-user-centered stakeholders. To make the research-to-product transition, we had to focus on adoption-centered design, the process of understanding and designing for adopters and stakeholders of the product. Our case study raises questions about how we evaluate the novelty and research contributions of HCI innovations with respect to their potential for commercial impact.
Public rental housing and its association with mortality – a retrospective, cohort study (2018)

Socioeconomic status (SES) is a well-established determinant of health status and home ownership is a commonly used composite indicator of SES. Patients in low-income households often stay in public rental housing. The association between public rental housing and mortality has not been examined in Singapore. A retrospective, cohort study was conducted involving all patients who utilized the healthcare facilities under SingHealth Regional Health (SHRS) Services in Year 2012. Each patient was followed up for 5 years. Patients who were non-citizens or residing in a non-SHRS area were excluded from the study. A total of 147,004 patients were included in the study, of which 7252 (4.9%) patients died during the study period. The mean age of patients was 50.2 ± 17.2 years old and 7.1% (n = 10,400) of patients stayed in public rental housing. Patients who passed away had higher utilization of healthcare resources in the past 1 year and a higher proportion stayed in public rental housing (p < 0.001). They also had higher rates of co-morbidities such as hypertension, hyperlipidaemia and diabetes. (p < 0.001) After adjustment for demographic and clinical covariates, residence in public rental housing was associated with increased risk of all-cause mortality (Adjusted hazard ratio: 1.568, 95% CI: 1.469–1.673). Public rental housing was an independent risk factor for all-cause mortality. More studies should be conducted to understand health-seeking behavior and needs of public rental housing patients, to aid policymakers in formulating better plans for improving their health outcomes.