gebhart/patrepeval huggingface dataset:
Coherent Terahertz Holographic and Tomographic Imaging (2012)

This talk will survey the application of digital holographic and tomographic techniques to highly coherent, single frequency terahertz sources and extremely sensitive heterodyne receivers for high resolution three dimensional reconstructions of extended, visibly opaque objects.
Evaluation and Management of Infections in Patients with Collagen Vascular Disease (1988)

The clinical outcome of patients with the various manifestations of collagen vascular disease (CVD) has significantly improved over the past two decades with the increased use of diuretics, cytotoxic agents, dialysis, transplantation, and the judicious use of corticosteroids and other antiinflammatory agents directed at altering or delaying end-organ damage by the underlying immunopathologic process.1–4 A more rigorous definition of the various CVD clinical syndromes and a greater sophistication in the serologic, radiologic, and pathologic diagnostic methods have meant that patients with these diseases are now coming to clinical attention earlier in the course of their illness. Consequently, the physician is now encountering a greater number of clinical problems over a longer time span for each individual patient, rather than just the well-known complications of their end-stage disease.
On the performance of LTE-Advanced MIMO: How to set and reach beyond 4G targets (2012)

Standardization of 3GPP LTE-Advanced (LTE-A), also called as 4G, is continuing strongly. Yet, in parallel the discussion on performance targets for systems beyond 4G have been initiated in industry. The aim of this paper is to investigate the link level performance of LTE-A downlink (DL) when large antenna array MIMO is employed. The link level simulation results show very high user throughputs when employing e.g. 8x8 MIMO. Yet, the comparison between simulation results and known spectral efficiency bounds show that LTE-A performance is still quite far away from theoretical limits. Results also indicate that realistic beyond 4G peak rate target on link level can be set close to 10 Gbps provided that 8x8 MIMO and 256QAM are applied, and the operation bandwidth can be doubled from current 100MHz. The spatial correlation in both transmitter and receiver ends will reduce the performance.
A hybrid genetic algorithm for optimizing sensing parameters in 3D motion estimation applications (2003)

This paper introduces an active vision approach for object motion estimation. The approach is formulated as a problem of controlling the pose of a vision system with the goal of minimizing the uncertainties of the motion estimates. A Kalman filter is employed as the object motion estimation algorithm. The uncertainties of the motion estimates are represented by the variances of the estimates produced by Kalman filter. These variances are updated by a Riccati equation which is constructed as a function of the vision system parameters. A hybrid genetic algorithm is proposed to search for the optimal vision system parameters that minimize the uncertainties of the motion estimates. This hybrid algorithm incorporates the concept of Boltzman's probability from simulated annealing. To improve the speed and accuracy of the proposed algorithm an adaptive gradient based search method is also developed.
P‐28: ZnO TFTs Fabricated at Room Temperature by Solution Process (2008)

Abstract The ZnO nanorods TFT using solution process was investigated. The nanorods were well‐chemically synthesized by ultrasonic methods and their length and diameter were adjusted to about 50∼150nm and 5∼15nm, respectively. The nanorods were coated onto SiO 2 substrate by spin casting. The nanorods films were treated at room temperature condition. The device exhibits an on‐to‐off current ratio of 8.6 × 10 5 and a field mobility 2.1 cm 2 V −1 s −1 .
Safety and efficacy of a probiotic-containing infant formula supplemented with 2’-fucosyllactose: a double-blind randomized controlled trial (2022)

The trial was registered on ClinicalTrials.gov ( NCT03090360 ) on 24/03/2017.
Crystal structure of wild-type (WT) human Glutamate oxaloacetate transaminase 1 (GOT1) (2018)

Pancreatic cancer cells are characterized by deregulated metabolic programs that facilitate growth and resistance to oxidative stress. Among these programs, pancreatic cancers preferentially utilize a metabolic pathway through the enzyme aspartate aminotransferase 1 [also known as glutamate oxaloacetate transaminase 1 (GOT1)] to support cellular redox homeostasis. As such, small molecule inhibitors that target GOT1 could serve as starting points for the development of new therapies for pancreatic cancer. We ran a high-throughput screen for inhibitors of GOT1 and identified a small molecule, iGOT1-01, with in vitro GOT1 inhibitor activity. Application in pancreatic cancer cells revealed metabolic and growth inhibitory activity reflecting a promiscuous inhibitory profile. We then performed an in silico docking analysis to study inhibitor-GOT1 interactions with iGOT1-01 analogues that possess improved solubility and potency properties. These results suggested that the GOT1 inhibitor competed for binding to the pyridoxal 5-phosphate (PLP) cofactor site of GOT1. To analyze how the GOT1 inhibitor bound to GOT1, a series of GOT1 mutant enzymes that abolished PLP binding were generated. Application of the mutants in X-ray crystallography and thermal shift assays again suggested but were unable to formally conclude that the GOT1 inhibitor bound to the PLP site. Mutational studies revealed the relationship between PLP binding and the thermal stability of GOT1 while highlighting the essential nature of several residues for GOT1 catalytic activity. Insight into the mode of action of GOT1 inhibitors may provide leads to the development of drugs that target redox balance in pancreatic cancer.
An effective and simple relevance feedback algorithm for image retrieval (2003)

Relevance feedback in content-based image retrieval has been an active research focus for many years. It uses user-labeled information to re-adjust the measurement of similarity between images to get the improved retrieval results. In this paper we propose a simple and effective approach for image relevance feedback, which uses both positive and negative examples labeled by users to refine the query and update the distance measurement dynamically. Our method not only has a very low complexity but also adapts well to the changes of user’s retrieval interests. Experimental results on a database of 7,000 images represented by MPEG-7 color and texture descriptors show the efficiency of our algorithm compared with other two existing algorithms.
Genetic Gain for Soybean Seed Protein, Oil, and Yield in a Recombinant Inbred Line Population (2018)

Abstract The use of soybean [ Glycine max (L.) Merrill] is widespread, with applications in food, fuel, livestock feed, and industrial products. We developed a soybean population of 239 F 4 ‐derived recombinant inbred lines (RIL) from the cross “5601T” × U99‐310255 to estimate the heritability and genetic gain for seed protein, oil, and yield, and to assess the utility of making selections for these important traits. Heritability estimates on an entry means basis for protein (0.78), oil (0.65), seed yield (0.38) varied by trait with regard to genetic influence. Genetic gain was calculated for each trait at 5%, 10%, 15%, and 20% selection intensities. With the genetic gain that was obtained through the selections for each trait, some lines excelled above that of the checks and parents in this population. The second and third highest yielding selections (56U99‐081 and 56U99‐244) are notable in producing 50.2% and 49.8% meal protein, respectively, while maintain high yields above the high‐yielding parent, 5601T. Seeking balance for these important soybean traits is essential for breeders looking to make optimal improvements for the wide variety of soybean uses. Further research on this population could prove to be of value to breeding programs wishing to increase seed yield, oil, and protein.
Early Enhanced Expression of Interferon-Inducible Protein-10 (CXCL-10) and Other Chemokines Predicts Adverse Outcome in Severe Acute Respiratory Syndrome (2005)

Increased plasma IP-10 during the first week of SARS symptoms is an independent predictor of outcome. Chemokine activation may be an early event in SARS, and an exaggerated host response may produce complications.
Policy management for networked systems and applications (2005)

In this paper, we present a novel policy middleware architecture for managing IT systems and applications that span multiple networks and administrative domains. The proposed policy middleware provides a standard infrastructure for the creation, storage, distribution, and execution of policies, and helps in reducing the cost of making IT systems policy-aware. In particular, we focus on three aspects of the proposed policy middleware that help in making the middleware fully general: (1) a platform-neutral and extensible specification of policies; (2) the local ratification of policies, which lets system administrators accept, reject, or flag an incoming policy; and (3) the transformation of policies, which allows system administrators to transform incoming policies to match their local environment. We present our experience in building an application on the proposed middleware to audit the configuration of a storage area network. We also present performance results from a prototype and show that our policy middleware design can scale to handle a large number of policies.
KRIT1 , a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein (2002)

Mutations in Krev1 interaction trapped gene 1 ( KRIT1 ) cause cerebral cavernous malformation, an autosomal dominant disease featuring malformation of cerebral capillaries resulting in cerebral hemorrhage, strokes, and seizures. The biological functions of KRIT1 are unknown. We have investigated KRIT1 expression in endothelial cells by using specific anti-KRIT1 antibodies. By both microscopy and coimmunoprecipitation, we show that KRIT1 colocalizes with microtubules. In interphase cells, KRIT1 is found along the length of microtubules. During metaphase, KRIT1 is located on spindle pole bodies and the mitotic spindle. During late phases of mitosis, KRIT1 localizes in a pattern indicative of association with microtubule plus ends. In anaphase, the plus ends of the interpolar microtubules show strong KRIT1 staining and, in late telophase, KRIT1 stains the midbody remnant most strongly; this is the site of cytokinesis where plus ends of microtubules from dividing cells overlap. These results establish that KRIT1 is a microtubule-associated protein; its location at plus ends in mitosis suggests a possible role in microtubule targeting. These findings, coupled with evidence of interaction of KRIT1 with Krev1 and integrin cytoplasmic domain-associated protein-1 alpha (ICAP1 α), suggest that KRIT1 may help determine endothelial cell shape and function in response to cell–cell and cell–matrix interactions by guiding cytoskeletal structure. We propose that the loss of this targeting function leads to abnormal endothelial tube formation, thereby explaining the mechanism of formation of cerebral cavernous malformation (CCM) lesions.
Zopfiellamides A and B, Antimicrobial Pyrrolidinone Derivatives from the Marine Fungus Zopfiella latipes. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Model-based characterization of the transpulmonary circulation by DCE-MRI (2016)

Objective measures to assess pulmonary circulation status would improve heart failure patient care. We propose a method for the characterization of the transpulmonary circulation by DCE-MRI. Parametric deconvolution was performed between contrast agent fifirst passage time-enhancement curves derived from the right and left ventricular blod pol. The transpulmonary circulation was characterized as a linear system with impulse response modelled as local density random walk model. We tested the method on 32 heart failure patients and 19 healthy volunteers; patients presented longer transpulmonary transit times and more skewed transpulmonary impulse responses.
Improved long-term cardiovascular outcomes after intensive versus standard screening of diabetic complications: an observational study (2019)

Among T2D patients attending a specialist outpatient clinic, intensive complication screening is followed by better long-term cardiovascular outcomes. No significant effect was noted for cardiovascular and all-cause mortality and the benefit was mainly driven by a reduced rate of hospitalization for heart failure.
Supplementary Materials and Methods from Bispecific Antibodies and Antibody–Drug Conjugates (ADCs) Bridging HER2 and Prolactin Receptor Improve Efficacy of HER2 ADCs (2023)

&lt;p&gt;Supplementary Materials and Methods&lt;/p&gt;
Compact Physics-Based Circuit Models for Graphene Nanoribbon Interconnects (2009)

Physics-based equivalent circuit models are presented for armchair and zigzag graphene nanoribbons (GNRs), and their conductances have been benchmarked against those of carbon nanotubes and copper wires. Atomically thick GNRs with smooth edges can potentially have smaller resistances compared with copper wires with unity aspect ratios for widths below 8 nm and stacks of noninteracting GNRs can have substantially smaller resistivities compared to Cu wires. It is shown that rough edges can increase the resistance of narrow GNRs by an order of magnitude. This fact highlights the need for patterning methods that can produce relatively smooth edges to fabricate low resistance GNR interconnects.
Human Immunodeficiency Virus Neurotropism: an Analysis of Viral Replication and Cytopathicity for Divergent Strains in Monocytes and Microglia (1998)

Productive replication of human immunodeficiency virus type 1 (HIV-1) in brain macrophages and microglia is a critical component of viral neuropathogenesis. However, how virus-macrophage interactions lead to neurological disease remains incompletely understood. Possibly, a differential ability of virus to replicate in brain tissue macrophages versus macrophages in other tissues underlies HIV-1 neurovirulence. To these ends, we established systems for the isolation and propagation of pure populations of human microglia and then analyzed the viral life cycles of divergent HIV-1 strains in these cells and in cultured monocytes by using identical viral inocula and indicator systems. The HIV-1 isolates included those isolated from blood, lung tissue, cerebrospinal fluids (CSF), and brain tissues of infected subjects: HIV-1(ADA) and HIV-1(89.6) (from peripheral blood mononuclear cells), HIV-1(DJV) and HIV-1(JR-FL) (from brain tissue), HIV-1(SF162) (from CSF), and HIV-1(BAL) (from lung tissue). The synthesis of viral nucleic acids and viral mRNA, cytopathicity, and release of progeny virions were assessed. A significant heterogeneity among macrophage-tropic isolates for infection of monocytes and microglia was demonstrated. Importantly, a complete analysis of the viral life cycle revealed no preferential differences in the abilities of the HIV-1 strains tested to replicate in microglia and/or monocytes. Macrophage tropism likely dictates the abilities of HIV-1 to invade, replicate, and incite disease within its microglial target cells.
Crystal phase engineering of self-catalyzed GaAs nanowires using a RHEED diagram (2020)

It is well known that the crystalline structure of the III-V nanowires (NWs) is mainly controlled by the wetting contact angle of the catalyst droplet which can be tuned by the III and V flux. In this work we present a method to control the wurtzite (WZ) or zinc-blende (ZB) structure in self-catalyzed GaAs NWs grown by molecular beam epitaxy, using <i>in situ</i> reflection high energy electron diffraction (RHEED) diagram analysis. Since the diffraction patterns of the ZB and WZ structures differ according to the azimuth [11̄0], it is possible to follow the evolution of the intensity of specific ZB and WZ diffraction spots during NW growth as a function of the growth parameters such as the Ga flux. By analyzing the evolution of the WZ and ZB spot intensities during NW growth with specific changes of the Ga flux, it is then possible to control the crystal structure of the NWs. ZB GaAs NWs with a controlled WZ segment have thus been realized. Using a semi-empirical model for the NW growth and our <i>in situ</i> RHEED measurements, the critical wetting angle of the Ga catalyst droplet for the structural transition is deduced.
Budding Capability of the Influenza Virus Neuraminidase Can Be Modulated by Tetherin (2011)

We have determined that, in addition to its receptor-destroying activity, the influenza virus neuraminidase is capable of efficiently forming virus-like particles (VLPs) when expressed individually from plasmid DNA. This observation applies to both human subtypes of neuraminidase, N1 and N2. However, it is not found with every strain of influenza virus. Through gain-of-function and loss-of-function analyses, a critical determinant within the neuraminidase ectodomain was identified that contributes to VLP formation but is not sufficient to accomplish release of plasmid-derived VLPs. This sequence lies on the plasma membrane-proximal side of the neuraminidase globular head. Most importantly, we demonstrate that the antiviral restriction factor tetherin plays a role in determining the strain-specific limitations of release competency. If tetherin is counteracted by small interfering RNA knockdown or expression of the HIV anti-tetherin factor vpu, budding and release capability is bestowed upon an otherwise budding-deficient neuraminidase. These data suggest that budding-competent neuraminidase proteins possess an as-yet-unidentified means of counteracting the antiviral restriction factor tetherin and identify a novel way in which the influenza virus neuraminidase can contribute to virus release.
Data Structures (2016)

Data structure is a way of organizing data in a computer memory so that it can be used efficiently. Data structures can implement one or more particular abstract data types (ADT), which are the means of specifying the nature of operations and their complexity. This book focuses on the design and analysis of basic data structures and their implementation and intends to provide a strong conceptual and empirical understanding of data structures. The contents of this book will help the students to understand that how the data structures are implemented and why these implementations are vital. The initial chapters deal with introductory part of the subject and the later chapters focus on advanced and difficult problems and algorithms. The book explains how data is organized in computer memory; how it operates; and why it is important. Appendixes provide further information on algorithms along with their programming solutions. Readers of this book need only to be familiar with the basic syntax of C/C++ and similar languages. This book will be useful for B.Tech/M.Tech Computer Science and Engineering, IT Engineering, BSc (IT)/MSc (IT), and BCA/MCA students.
ADVANCES IN WOUND CLOSURE: A BARBED APPROACH (2015)

Wound closure is typically not the surgeon9s favorite part of the case. It is critical, however, for preventing infection, avoiding early re-operation and is the portion of the procedure that is most directly visible to the patient. The purpose of this study was to investigate the use of bidirectional, barbed suture for wound closure in primary total hip (THA) and knee arthroplasty (TKA) to determine whether its use is safe, cosmetic and associated with time savings when compared with traditional suture. We carried out a blinded, randomised controlled trial comparing bidirectional, barbed suture (Quill™ SRS; Angiotech Pharmaceuticals) and a traditional absorbable layered closure following primary THA and TKA. We randomised 20 THAs (10 Quill; 10 traditional) and 31 TKAs (16 Quill; 15 traditional). Power analysis determined that a minimum of 23 patients per arm of the study were required to show a significant difference in closure times using an alpha of 0.05 and a beta of 0.80. Wound closure in the Quill group was significantly faster than traditional suture by a mean of 4.1 minutes (9.2 vs. 13.2 minutes; p = 0.0005). Traditional closure required a mean 5.6 sutures, compared to a mean 2.7 sutures (p Our results have been confirmed by a similar recently published randomised study by Gilland et al, who showed a mean reduction in closure time of 4.7 minutes. However, these authors concluded that overall costs were lower with a barbed suture based on a reduction in operative times. This method of closure has also been shown to provide a stronger and more water-tight closure than traditional interrupted sutures.
Ethylene Interacts with Abscisic Acid to Regulate Endosperm Rupture during Germination: A Comparative Approach UsingLepidium sativumandArabidopsis thaliana (2009)

The micropylar endosperm cap covering the radicle in the mature seeds of most angiosperms acts as a constraint that regulates seed germination. Here, we report on a comparative seed biology study with the close Brassicaceae relatives Lepidium sativum and Arabidopsis thaliana showing that ethylene biosynthesis and signaling regulate seed germination by a mechanism that requires the coordinated action of the radicle and the endosperm cap. The larger seed size of Lepidium allows direct tissue-specific biomechanical, biochemical, and transcriptome analyses. We show that ethylene promotes endosperm cap weakening of Lepidium and endosperm rupture of both species and that it counteracts the inhibitory action of abscisic acid (ABA) on these two processes. Cross-species microarrays of the Lepidium micropylar endosperm cap and the radicle show that the ethylene-ABA antagonism involves both tissues and has the micropylar endosperm cap as a major target. Ethylene counteracts the ABA-induced inhibition without affecting seed ABA levels. The Arabidopsis loss-of-function mutants ACC oxidase2 (aco2; ethylene biosynthesis) and constitutive triple response1 (ethylene signaling) are impaired in the 1-aminocyclopropane-1-carboxylic acid (ACC)-mediated reversion of the ABA-induced inhibition of seed germination. Ethylene production by the ACC oxidase orthologs Lepidium ACO2 and Arabidopsis ACO2 appears to be a key regulatory step. Endosperm cap weakening and rupture are promoted by ethylene and inhibited by ABA to regulate germination in a process conserved across the Brassicaceae.