gebhart/patrepeval huggingface dataset:
Effect of Pressure‐Flow Relationship of Centrifugal Pump on In Vivo Hemodynamics: A Consideration for Design (1998)

We have been developing centrifugal pumps for an implantable left ventricular assist device. We manufactured 2 prototype centrifugal pumps (PI, PII). These two have similar designs except for the PII having a volute casing and a large output port. To determine the differences in the hydraulic characteristics between the PI and PII, we carried out in vitro and in vivo experiments. In vitro study showed that the PII had a shallower H-Q curve than that of the PI, and the PII required a pump speed faster than the PI for the same flow rate and pressure head. On the other hand, in vivo study showed that the PII demonstrated a flow pulsatility greater than that of the PI at 1,900 rpm and 8 L/min although no significant change was observed at low pump speeds (< or = 1,500 rpm). This greater pulsatility consisted of a large discharge according to the small differential pressure during the systolic phase and a small discharge according to the large differential pressure during the diastolic phase. In contrast, the PI, having the steeper H-Q curve, showed a small discharge in the systolic phase and a large discharge in the diastolic phase. These results showed that pulsatility synchronized with the native heart beating depended on the slope of the H-Q curve. As a result, the slope of the H-Q curve is important to determine the component of pulsatility synchronized with native cardiac output. Regarding the slope of the H-Q curve, a pump having a volute casing and a large outlet port demonstrates a shallow slope in the H-Q curve. In conclusion, we suggest that a centrifugal pump for use in left ventricular aortic bypass should be designed considering the effect on the native heart pulsatility.
Differential mode EMC input filter design for three-phase AC-DC-AC sparse matrix PWM converters (2004)

The design of a differential-mode EMC input filter for a three-phase AC-DC-AC very sparse matrix converter intended for electrical machine drive applications is discussed in this paper. A review of the steps to be performed in the course of the filter design is presented and a detailed mathematical model of the EMI test receiver for quasipeak measurement of conducted emissions in the frequency range of 0.15...30 MHz is established. Furthermore, formulas for the estimation of the quasipeak detector output based on the LISN output voltage spectrum are provided. As experimentally verified by using a novel three-phase CM/DM separator this procedure allows an accurate prediction of the converter differential mode conducted emission levels and therefore could be employed in the design process for ensuring compliance to relevant EMC standards.
Improving methods of resident selection (2010)

Using tools of occupational analysis and personnel selection, a list of job objectives and competencies for the junior otolaryngology resident can be created. Using these results, behavioral-based interviews may be implemented to complement traditional interviews with the ultimate goal of improving candidate selection.
Changes of Protein Expression after CRISPR/Cas9 Knockout of miRNA-142 in Cell Lines Derived from Diffuse Large B-Cell Lymphoma (2022)

Seed-sequence mutants of miR-142 confirmed potential targets and novel targets of miRNAs can be identified in miRNA knockout cell lines. Due to the complex contribution of miRNAs within cellular regulatory networks, in particular when miRNAs highly present in RISC complexes are replaced by other miRNAs, primary effects on gene expression may be covered by secondary layers of regulation.
Clinical Roundup: Selected Treatment Options for Depression (2014)

Depression is known to be associated with physical illnesses, immune function, and mortality from suicide. 1 Given the pharmacological therapy limitations in treating depression, other non-invasive complementary methods integrated with mainstream medicine must be explored. Auriculotherapy (AT), an approach involving traditional Chinese medicine (TCM), is proposed as a therapy for patients suffering from depression, wherein specific points on the auricle are punctured or stimulated to treat various disorders of the body. 2 It is a specialized form of acupuncture that treats the ear as a microsystem of the body.
Regional examination shows potential for native feedstock options for cellulosic biofuel production (2009)

Abstract Kentucky, as with many regions around the globe, has a relatively long growing season with significant rainfall that could produce sizeable quantities of perennial herbaceous and woody biomass on land that does not compete with food crops. Additionally, there are limited options for renewable power production from low carbon sources such as solar‐photovoltaic, wind and hydroelectric. Recent studies have shown that producing renewable energy from perennial cellulosic crops, as opposed to starch‐based biofuel crops, will have a carbon‐mitigating outcome. Currently, there is a lack of data regarding regionally suitable genotypes. Herein, we establish baseline values for multiple entry selections of three native C4 grass species, switchgrass (SW) ( Panicum virgatum L.), eastern gamagrass (EG) (Trispicum dactyloides L. ) and big bluestem (BB) (Andropogon gerardii Vitman ) . Yield potential examined over 7 years showed that environment, species and entries had a significant impact on yield, but EG had higher total yield over the duration of the study. Cellulosic biofuel potential was examined by measurement of saccharification efficiency, relative lignocellulosic energy density, cellulose content and lignin content during three growing seasons. EG had significantly higher digestibility rate than SW and BB. Underlying this was a negative correlation between lignification and saccharification efficiency. However, higher lignin content and higher cellulose content among SW entries resulted in higher energy density relative to EG and BB. These data reveal that locally bred EG varieties were most suited to cellulosic ethanol production under the growing conditions of central Kentucky, USA, compared with SW and BB and suggest the importance of regional examination.
Release of hexazinone from pronone 10g granules exposed to simulated rainfall under laboratory conditions (1988)

Abstract The release of surface coated hexazinone, 3‐cyclohexyl‐6‐(di‐methylamino)‐1‐methyl‐1,3,5‐triazine‐2,4(1H,3H)‐dione, from a new granular formulation, PRONONE 10G, was tested under simulated rainfall. The release of hexazinone from PRONONE 10G granules treated with 1.3, 2.5 and 5.1 cm of rainfall were 65.5, 87.4 and 91.5 % with CV of 8.7, 2.9 and 5.4 %, respectively. Comparing with the conditions tested in this laboratory study, the amount of rainfall required for a 90% release of hexazinone under field conditions is estimated to be less than 5 cm of intermittent rain complemented with overnight dew over a period of time. Based on a sample of the PRONONE 10G formulation, a single granule weighed 20.9 mg (11% CV, n = 600) and contained 10.7% hexazinone (15.6% C.V.), 7% higher than the label 10% hexazinone content of this granular formulation.
Nanoelectromechanical tuning of slot dielectric metasurfaces (2022)

We present a design for nanoelectromechanical tuning of high-Q slot resonant dielectric metasurfaces. The design provides over 60% intensity modulation under 1.5V and independent modulation for multiwavelengths.
A flexible electronic strain sensor for the real-time monitoring of tumor regression (2022)

Assessing the efficacy of cancer therapeutics in mouse models is a critical step in treatment development. However, low-resolution measurement tools and small sample sizes make determining drug efficacy in vivo a difficult and time-intensive task. Here, we present a commercially scalable wearable electronic strain sensor that automates the in vivo testing of cancer therapeutics by continuously monitoring the micrometer-scale progression or regression of subcutaneously implanted tumors at the minute time scale. In two in vivo cancer mouse models, our sensor discerned differences in tumor volume dynamics between drug- and vehicle-treated tumors within 5 hours following therapy initiation. These short-term regression measurements were validated through histology, and caliper and bioluminescence measurements taken over weeklong treatment periods demonstrated the correlation with longer-term treatment response. We anticipate that real-time tumor regression datasets could help expedite and automate the process of screening cancer therapies in vivo.
BASOPHIL-LINEAGE COMMITMENT IN ACUTE PROMYELOCYTIC LEUKEMIA PREDICTS FOR SEVERE BLEEDING AFTER STARTING THERAPY (2018)

Severe hemorrhagic events occur in a significant fraction of acute promyelocytic leukemia patients, either at presentation and/or early after starting therapy, leading to treatment failure and early deaths. However, identification of independent predictors for high-risk of severe bleeding at diagnosis, remains a challenge. Here, we investigated the immunophenotype of bone marrow leukemic cells from 109 newly diagnosed acute promyelocytic leukemia patients, particularly focusing on the identification of basophil-related features, and their potential association with severe bleeding episodes and patient overall survival. From all phenotypes investigated on leukemic cells, expression of the CD203c and/or CD22 basophil-associated markers showed the strongest association with the occurrence and severity of bleeding (p ≤ 0.007); moreover, aberrant expression of CD7, coexpression of CD34+/CD7+ and lack of CD71 was also more frequently found among patients with (mild and severe) bleeding at baseline and/or after starting treatment (p ≤ 0.009). Multivariate analysis showed that CD203c expression (hazard ratio: 26.4; p = 0.003) and older age (hazard ratio: 5.4; p = 0.03) were the best independent predictors for cumulative incidence of severe bleeding after starting therapy. In addition, CD203c expression on leukemic cells (hazard ratio: 4.4; p = 0.01), low fibrinogen levels (hazard ratio: 8.8; p = 0.001), older age (hazard ratio: 9.0; p = 0.002), and high leukocyte count (hazard ratio: 5.6; p = 0.02) were the most informative independent predictors for overall survival. In summary, our results show that the presence of basophil-associated phenotypic characteristics on leukemic cells from acute promyelocytic leukemia patients at diagnosis is a powerful independent predictor for severe bleeding and overall survival, which might contribute in the future to (early) risk-adapted therapy decisions.
Image quality estimation for different spatial resolutions (2013)

State of the art visual quality assessment methods are effective when the input image and the reference image have the same resolution. However, estimating the quality of an image that has spatial resolution different than that of the reference image is still a challenging problem. In this work, we design a quality estimator (QE) to estimate the quality of a distorted image with a lower resolution compared to the reference image. We also present a subjective test environment to explore the success of the proposed algorithm in comparison with other QEs. The subjective tests demonstrate that the proposed method works better than other approaches.
Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase. (1991)

The 5-, 12-, and 15-lipoxygenases contain a highly conserved sequence of the form His-(X)4-His-(X)4-His-(X)17-His-(X)8-His which represents a potential binding site for non heme iron to the protein. The importance of selected amino acids within this His cluster for the activity of human 5-lipoxygenase was investigated by site-directed mutagenesis using bacteria and insect cells expression systems. After single mutation of each of the 5 His residues at positions 363, 368, 373, 391, and 400 by Ser, Cys, or Lys, measurable levels of 5-lipoxygenase activity could be recovered in Escherichia coli only for the Ser363 and Cys363 mutants, with most amino acid substitutions causing a decrease in the levels of expression of the soluble protein. In contrast, 25-80% of soluble 5-lipoxygenase activity was recovered after the replacement of several of the hydrophobic amino acids in this region: Tyr384 by Ser or Phe; Phe394 by Trp and Val375 by Ala. Met436 could be replaced by Leu with little effect on 5-lipoxygenase activity or turnover inactivation half-time. High levels of mutant 5-lipoxygenases containing a Ser residue instead of His at each of the five positions were also expressed in Spodoptera frugiperda (Sf9) cells infected with recombinant baculovirus. The specific activity (58-75% of control) and the reaction time course of the Ser363, Ser391, and Ser400 mutants were comparable with that of native 5-lipoxygenase whereas inactive proteins were obtained for the Ser368 and Ser373 mutants. These results show that His368 and His373 residues are important for 5-lipoxygenase activity and that the other conserved His363, His391, His400, and Met436 residues are not crucial for the catalytic cycle or for the mechanism of self-inactivation of 5-lipoxygenase.
Wide band channel characterization for low altitude unmanned aerial system communication using software defined radios (2018)

Design and Implement FMCW (chirp) sounders using SDRs for VLL UAS scenario. Proper choice of waveform. Reviewed two types of chirp detectors and discussed their relative merits. Illustrating the ability of the SDR chirp sounder to yield estimates of channel power delay profiles and scattering functions (delay-Doppler functions)Vary SIR We plan to use SDRs mounted on moving objects such as small VLL UAS to gather additional data and refine our processing techniques for channel measurements and modeling.
The Role of Smad3 in Mediating Mouse Hepatic Stellate Cell Activation (2001)

Transforming growth factor beta (TGF-beta) is the most potent profibrogenic mediator in liver fibrosis. Although Smad proteins have been identified as intracellular mediators in the TGF-beta signaling pathway, the function of individual Smad proteins remains poorly understood. The aim of this study was to explore the contribution of Smad3 in mediating TGF-beta responses in a model of acute liver injury in vivo and in culture-activated hepatic stellate cells (HSCs). Wild-type, Smad3 heterozygous or Smad3 homozygous knockout mice were treated with a single intragastric administration of CCl(4). After 72 hours, the induction of hepatic collagen alpha1(I) and alpha2(I) messenger RNA (mRNA) levels in Smad3 knockout mice was only 42% and 64%, respectively, of the levels induced in wild-type mice. However, smooth muscle alpha-actin (alpha-SMA) was expressed at a slightly higher level in livers from knockout mice compared with wild-type mice. In culture-activated HSCs from Smad3 knockout mice, collagen alpha1(I) mRNA was 73% of wild-type HSCs, but alpha-SMA expression was the same. HSCs from knockout mice showed a higher proliferation rate than wild-type HSCs. Smad3-deficient HSCs did not form TGF-beta1-induced Smad-containing DNA-binding complexes. In conclusion, (1) maximal expression of collagen type I in activated HSCs requires Smad3 in vivo and in culture; (2) Smad3 is not necessary for HSC activation as assessed by alpha-SMA expression; (3) Smad3 is necessary for inhibition of proliferation of HSCs, which might be TGF-beta-dependent; and (4) Smad3 is required for TGF-beta1-mediated Smad-containing DNA-binding complex formation in cultured HSCs.
Kinetics of cationic photopolymerizations of divinyl ethers characterized usingin situ Raman spectroscopy (1996)

In situ Raman spectroscopy experiments were used to determine effective kinetic propagation constants for a series of unsteady-state divinyl ether polymerizations at different isothermal temperatures and light intensities. Raman spectroscopy was found to be ideally suited for monitoring cationic photopolymerizations because the technique allows isothermal experiments to be performed with excellent time resolution and allows several spectral features to be observed simultaneously. In addition, the Raman experiments provided direct information about the vinyl bond concentration in situ as the reaction takes place. For these cationic photopolymerizations, the reaction rate and limiting conversion were both found to increase as the reaction temperature was increased. At all temperatures, the profile for the propagation rate constant, kp, exhibited a dramatic increase at the start of the reaction, plateaued at a value between 10 and 40 l/mol s (depending upon temperature), and then decreased as the reaction reached a limiting conversion due to trapping of the active centers. Finally, the overall activation energy for polymerization was found to be 25.1 ± 6.1 kJ/mol. © 1996 John Wiley & Sons, Inc.
Pericarditis constrictiva after aortic valve replacement simulating tricuspid stenosis (1992)

Pericarditis constrictiva after cardiac surgery is rare and may occasionally lead to congestive heart failure. The case of a 29-year-old patient is described who presented with pericarditis constrictiva after aortic valve replacement with localized tamponade, causing functional tricuspid stenosis. Pericardiectomy as the treatment of choice was curative.
The Lasker Awards—Recognizing and Highlighting Oncology Research (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Three-dimensional visualization of electrical variables in the ventricular wall of the heart (2002)

A set of programs developed to display the potentials and the magnitudes of the estimated potential gradients generated by defibrillation shocks are discussed. There are three types of displays. The first type displays three-dimensional surfaces constructed from electrode locations. Potentials or gradient magnitudes are interpolated over each surface and are displayed as spatial changes in intensity or hue. The second type of display is a three-dimensional surface reconstruction of the heart and electrodes. This display is used to verify the three-dimensional electrode coordinates that are obtained from digitized images of the heart. The third type of display is a volume reconstruction of the myocardium. In this display, spatial changes in potentials or gradient magnitudes in the myocardial volume are represented by spatially varying the hues of the volume elements. The electrical values of most volume elements are interpolated by means of a three-dimensional method based on discrete smooth interpolating.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Energy flux diagnostics in thin film deposition by magnetron sputtering (2015)

International audience
Searching Multimedia Data using MPEG-7 Descriptions in a Broadcast Terminal (2013)

MPEG-7 is an emerging standard for representing information carried by multimedia data. Such a standard is considered crucial for the oncoming integration of broadcast (TV) and Internet technologies and applications. This paper reports on the development of methods for searching multimedia data using MPEG-7 in the context of the SAMBITS application, and, in particular, in the development of a SAMBITS terminal. SAMBITS, a European broadcast application project, developed a multimedia studio and terminal technology for new interactive broadcast services based on the MPEG standards. This paper describes, after an introduction to MPEG7 and a description of SAMBITS, a retrieval model for MPEG-7 in a broadcast terminal. The retrieval model was developed and implemented using the HySpirit software, which is a flexible framework for representing complex data and describing retrieval functions effectively. A user interface was also implementing to provide insights in integrating a search functionality in a broadcast terminal.
Eu2+‐doped AlN—SiC solid‐solution phosphors: Synthesis and cathodoluminescence properties (2011)

Abstract— Eu and Si co‐doped AlN was reported to be an interesting blue phosphor for field‐emission displays (FEDs). In this paper, SiC instead of Si 3 N 4 was used as the Si source. Eu 2+ ‐doped AlN—SiC phosphors were prepared by firing the powder mixtures of AlN, SiC, and Eu 2 O 3 at 2050°C for 2 hours under 1‐MPa N 2 . Solid solutions between AlN and SiC were formed in a wide range, promoting the solution of Eu 2+ in AlN. The phosphors showed intense blue emissions under electron‐beam excitation, indicative of potential phosphors for FEDs.
Some results on MIMO mutual information: the high SNR case (2005)

We consider multiple-input multiple-output (MIMO) communication systems where the transmitted vector has a zero-mean complex Gaussian distribution, independently and identically distributed across the transmit antennas. For arbitrary fading statistics, we decompose a high-SNR approximation of the mutual information as a sum of three terms involving: (1) average SNR; (ii) SNR fading; and (iii) a term characterizing the "effective rank", or eigenvalue dispersion, of the channel matrix. For further insight, we derive the probability densities of the latter two terms under frequency-flat Rayleigh iid fading, and show that the component of mutual information due to SNR fading is asymptotically Gaussian (in the number of antennas) with variance depending only on the ratio of the number of transmit and receive antenna elements.