gebhart/patrepeval huggingface dataset:
Beneficial effect of low-dose mirtazapine in acute aripiprazole-induced akathisia (2014)

Low-dose mirtazapine was found to be efficacious for neuroleptic-induced akathisia. We evaluated whether mirtazapine is also effective for akathisia induced by the partial dopamine D2 receptor agonist aripiprazole. Medical charts were retrospectively analyzed for eight patients who developed akathisia while being treated with aripiprazole. All scored at least 2 (mild akathisia) on the Barnes Akathisia Rating Scale (BARS) and were treated with mirtazapine (15 mg/day) for a mean of 8.5 days. There was a statistically significant reduction in the BARS subjective, distress, and global (P<0.01 to P<0.001), but not objective (P=0.21) subscales. Five (62.5%) patients fulfilled the criteria of response, a decrease of at least two points on the BARS global subscale. Low-dose mirtazapine was well tolerated, and mild sedation, the only side effect (three patients), was transient. A large-scale controlled investigation is warranted to substantiate clinical utility of mirtazapine for akathisia induced by aripiprazole and other second-generation antipsychotics.
Compliant bump technology for back-side illuminated CMOS image sensor (2009)

We have developed a compliant bump technology for 3D chip stacking with the same number of inter-chip connections as that in a VGA (video graphic array, 640 times 480). Using this technology together with a through-Si via (TSV) technology, we demonstrate a prototype of back-side illuminated CMOS image sensor, in which a very-thin rear-illuminated photodiode array is electrically connected to the CMOS readout circuit at a pixel level.
Heat Transfer Experiments and Correlations for Low-Reynolds-Number Flows of Water in Vertical Annuli (1989)

Abstract This paper presents heat transfer data and correlations for hydrodynamically developed but thermally developing buoyancy-assisted and -opposed flows of water in vertical annuli at low Reynolds numbers (Re < 104). Data are for forced and mixed laminar flows, forced transitional and turbulent flows, and natural laminar and turbulent flows. A general correlation of the forced upflow data (Re < 104) is obtained by superimposing the correlations developed for forced laminar and transitional flows: NuF = (Nu9 F.L + Nu9 F.Tr)1/9. Similarly, the data for both the laminar and the mixed laminar flows as well as those for natural laminar flow are correlated by superimposing the correlations developed for forced laminar and natural laminar flows: NuL = (Nu3 F.L + Nu3 N.L)1/3. This correlation is in good agreement with the laminar and mixed downflow data, but with a negative sign for NuN.L Although Nu values for natural laminar flow increased proportionally to Ra0.2 q and those for natural turbulent flow increased proportionally to Ra0.285 q, all the natural flow data are correlated by superimposing the correlations developed for natural laminar and natural turbulent flows as NuN = (Nu3 N.L + Nu3 N.Tu)1/3
Mechanisms of extra-heavy oil recovery by gravity-stable CO2 injection (2008)

Compared with thermal methods, non-thermal production of heavy oil can offer advantages on capital cost, energy consumption, environmental pollution, and safety. It also offers a solution for recovery from heavy oil reservoirs in which thermal methods are inefficient or not feasible. However, many advantages of heavy oil non-thermal production methods are usually contrasted by their low recovery factor. Pressure depletion, vapour extraction (Vapex) and water flooding are amongst the cold production recovery options but each has major drawbacks. Alternative non-thermal processes are therefore needed to increase oil recovery from heavy oil reservoirs. CO2 injection is increasingly considered as having potential applications as a possible IOR process. Displacement and recovery of conventional (light) oil with CO2 has been studied and applied extensively. However, much less experience has been gained on recovery of heavy and extra-heavy oil by CO2 and hence, this process is less understood. In this paper we present the results of visualisation experiments carried out in a highpressure transparent micromodel to investigate the performance of gravity-stable CO2 injection in an extra-heavy crude oil. We reveal the pore-scale interactions of CO2-oilwater and mechanisms of displacement and recovery through vivid micromodel images and videos. During extended periods of CO2 injection, the colour of the heavy crude oil was observed to change gradually but drastically from black to light brown as a result of the dilution of heavy oil with CO2. The discoloured diluted oil was readily mobilised and recovered during water injection carried out subsequent to CO2 injection and resulted in a very high oil recovery. The presence of water was observed to adversely affect the performance of CO2 injection. The results improve our understanding of the mechanisms of heavy oil recovery by CO2 and water injection and demonstrate a huge potential for CO2 injection as a heavy oil recovery method, which can provide energy, economic and environmental benefit.
31P NMR studies of Redox reactions of Bis (Trialkylphosphine) Gold(I) Bromide (Alkyl = Methyl, Ethyl) with Disulphide and Diselenide ligands (2004)

Redox reactions of bis (trialkylphosphine) gold(I) bromide (alkyl = methyl, ethyl) with two diselenides (R′Se–SeR′), selenocystine and selenocystamine and their corresponding disulfides were studied in D2O by 31P NMR spectroscopy. Upon interaction of diselenides with (Me3P)2AuBr or with (Et3P)2AuBr, the Se–Se bond is broken, resulting in the formation of R3PAu+, R′SeH, R′Se–Au–PR3, R3PO and (AuSeR′) n . Second-order rate constants were determined for the decomposition of (R3P)2AuBr. Selenocystamine reacts with (Et3P)2AuBr about 100 times faster than its corresponding disulfide. However, cystamine reacts twice as fast with (Me3P)2AuBr compared to its corresponding diselenide.
In-Grown Stacking Faults in SiC-CVD Using Dichlorosilane and Propane as Precursors (2012)

In-grown stacking faults (IGSFs) were studied in 4H-SiC homoepitaxial growth from a SiH 2 Cl 2 -C 3 H 8 -H 2 system. Most of the IGSFs, start from the epilayer/substrate interface, and exhibit photoluminescence emission peak at 2.58 eV (480 nm) indicating of 8H polytype. The growth parameters, including growth temperature, growth pressure, growth rate, hydrogen etching, et al., varied around the regular growth condition do not show a significant effect on the IGSF generation. Reactor furniture is identified to be a major reason of IGSF formation, especially when the insulation part of the furnace is not completely isolated from the growth zone. Dusting of insulation material is crucial in the formation of IGSFs. When using graphite felt as the insulation material, the IGSF density in the epilayer can be as high at ~10 4 cm -2 . Improvement of the insulation material by using graphite foil reduces the density to 30-100 cm -2 . Further reduction of IGSF density to less than 10 cm -2 is achieved by mild pretreatment of the substrate in molten KOH-NaOH eutectic.
Expanding the eukaryotic genetic code (2023)

This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
SOI and Other Semiconductor-On-Insulator Substrates Characterization (2009)

We focus in this paper on SOI and new engineered on-insulator substrates characterization. After a short review of on-line characterization techniques, we will detail off-line monitoring techniques such as preferential etching and Raman spectroscopy. We will especially highlight their complementarity on strained layers and the need for a proper evaluation of structural quality of on-insulator substrates.
77. Clinical Scale Zinc Finger Nuclease (ZFN)-Driven Gene-Editing of PD-1 in Tumor Infiltrating Lymphocytes (TIL) for the Potential Treatment of Metastatic Melanoma (2015)

Multiple inhibitory pathways are exploited by a number of cancers to block the body's immune response which may limit the effectiveness of adoptive cell transfer (ACT). Programmed cell death-1 (PD-1) is a member of the CD28 superfamily and is expressed on activated T cells. Importantly, its ligands, PDL-1 and PDL-2 are expressed on a variety of tumor cells, including melanoma. The binding of PD-1 to PDL-1 inhibits T cell effector function, and represents an important mechanism for PDL-1 expressing tumors to evade the host immune response to cancer. PD-1 thus represents an attractive target for gene-editing of tumor targeted T cells prior to ACT. Here we describe the elimination of PD-1 expression in tumor infiltrating lymphocytes (TIL) by genome-editing using zinc finger nucleases (ZFNs) directed against the PDCD1 gene at a scale sufficient for patient treatment. Using the MaxCyte GT Flow Transfection System to deliver mRNA encoding the PD-1 specific ZFNs, the clinical scale TIL production process yielded efficient modification of the PDCD1 gene locus (mean = 74.8% of alleles, n=3, range = 69.9 – 84.1%), which resulted in a 76% reduction in PD-1 surface-expression. Importantly, the PD-1 modified TIL products displayed an effector memory phenotype and expanded approximately 500 – 2000 fold during a rapid cell expansion. In addition, PD-1 modified and unmodified TILs showed equivalent levels of engraftment in a NSG-mouse model. PD-1 modified TILs demonstrated improved in vitro T cell effector functions relative to controls (statistically significant greater TNFα, GM-CSF and IFNγ cytokine secretion when co-cultured with MART-1+ tumor cells). Preliminary safety evaluations showed that PD-1 modified TILs maintained IL-2 dependent growth in vitro, and no tumors were observed in an NSG-mouse tumorigenicity study. These data support the further study of the efficacy and safety of adoptive cell transfer using PD-1 gene-edited TIL for the treatment of metastatic melanoma.
Effect of a porous Pt/alumina cover layer for V<sub>2</sub>O<sub>5</sub>/WO<sub>3</sub>/TiO<sub>2</sub> resistive SO<sub>2</sub> sensing materials (2013)

Planar resistive type SO2 sensors based on V2O5/WO3/TiO2 (VWT) have been reported to respond well to SO2 but with large cross-effects of NO and NH3. In this study, we added a porous Pt/alumina cover layer on a VWT film in order to decrease the cross sensitivities. The sensor response to SO2 is hardly affected by the Pt/alumina layer in the case of VWT sensor with 3.0 wt % V2O5 with Au electrodes, while the Pt/alumina layer affects the response of other VWT sensors. The VWT sensor (3.0 wt % V2O5) with Au electrodes with the porous Pt/alumina cover layer shows much smaller responses to CO, H2, H2O, NH3, and NO compared with the sensor without Pt/alumina cover layer. The porous Pt/alumina cover layer has a potential to improve the selectivity of the VWT sensor.
Dispersion control with reflection grisms of an ultra-broadband spectrum approaching a full octave (2010)

We report the design, implementation, and characterization of a grism-pair stretcher in a near-infrared noncollinear optical parametric chirped-pulse amplifier (OPCPA) that is capable of controlling a bandwidth of 440 nm. Our dynamic dispersion control scheme relies on the grism stretcher working in conjunction with an acousto-optic programmable dispersive filter (Dazzler) to jointly compensate large amount of material dispersion. A spectral interference technique is used to characterize the spectral phase of the grism stretcher. This ultra-broadband device opens up the way to generate sub-2-cycle laser pulses.
Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice (2015)

The M1 muscarinic acetylcholine receptor (mAChR) subtype has been implicated in the underlying mechanisms of learning and memory and represents an important potential pharmacotherapeutic target for the cognitive impairments observed in neuropsychiatric disorders such as schizophrenia. Patients with schizophrenia show impairments in top-down processing involving conflict between sensory-driven and goal-oriented processes that can be modeled in preclinical studies using touchscreen-based cognition tasks. The present studies used a touchscreen visual pairwise discrimination task in which mice discriminated between a less salient and a more salient stimulus to assess the influence of the M1 mAChR on top-down processing. M1 mAChR knockout (M1 KO) mice showed a slower rate of learning, evidenced by slower increases in accuracy over 12 consecutive days, and required more days to acquire (achieve 80% accuracy) this discrimination task compared to wild-type mice. In addition, the M1 positive allosteric modulator BQCA enhanced the rate of learning this discrimination in wild-type, but not in M1 KO, mice when BQCA was administered daily prior to testing over 12 consecutive days. Importantly, in discriminations between stimuli of equal salience, M1 KO mice did not show impaired acquisition and BQCA did not affect the rate of learning or acquisition in wild-type mice. These studies are the first to demonstrate performance deficits in M1 KO mice using touchscreen cognitive assessments and enhanced rate of learning and acquisition in wild-type mice through M1 mAChR potentiation when the touchscreen discrimination task involves top-down processing. Taken together, these findings provide further support for M1 potentiation as a potential treatment for the cognitive symptoms associated with schizophrenia.
Monitoring Patient Activity during Chemotherapy with Wearable Fitness Devices (2016)

Chemotherapy is a common treatment of neoplasm with highly varying outcome. The efficiency of the therapy and the caused side effects depend strongly on the tolerance rate of the patient. The tolerance is expected to be higher for active people. Here we present a preliminary work on setting up a protocol for monitoring the activity rate of patients during chemotherapeutic treatment. Our setup consists of a set of commercial fitness devices and a central server for evaluating data. We showcase criteria for selecting the appropriate device and discuss the possibilities of scaling up the configuration. We also consider aspects of patients' anonymity and how the proposed protocol compares to traditional methods.
IR electrochromics from block copolymer-architectured doped metal oxide nanocrystals (2013)

Total energy consumption by com. and residential buildings in the US nears 40 Quads. Approx. 1/3 of that energy use is due to space heating and cooling. Recent anal. of materials that comprise the building envelope would benefit from smarter windows that more effectively managed heat. We will describe recent efforts in using doped metal oxide nanocrystals in electrochromic windows to manage solar heat gain in buildings. These nanocrystals show switchable absorption properties in the IR due to their dynamically tunable surface plasmon resonances. We will describe the impact of different mesoscale nanocrystal architectures on the switching, optical properties, etc - which are controllable by block copolymer-directed assembly.
Abelian surfaces admitting an (l,l)-endomorphism (2011)

We give a classification of all principally polarized abelian surfaces that admit an $(l,l)$-isogeny to themselves, and show how to compute all the abelian surfaces that occur. We make the classification explicit in the simplest case $l=2$. As part of our classification, we also show how to find all principally polarized abelian surfaces with multiplication by a given imaginary quadratic order.
Supplemental Figures and Table from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase (2023)

&lt;p&gt;Supplemental material containing a flowchart for how the 15-miRNA signature was generated, a table of pertinent patient clinical data, and a forest plot of hazard ratios of high-risk colon, pancreatic, and stomach cancer patients with high miRNA signatures.&lt;/p&gt;
Synchronization of a Single-Phase Photovoltaic Generator With the Low-Voltage Utility Grid (2011)

The increased generation of electrical energy from renewable sources and its integration into the low voltage grid, has necessitated regulations governing the connection of renewable energy generators to the grid. This was deemed necessary to preserve the integrity and the correct operation of the grid. This paper presents a new architecture of a hybrid phase lock loop circuit topology for synchronizing a single-phase inverter fed from a renewable energy source such as a photovoltaic (PV) generator to the low voltage grid. The system uses a digital phase lock loop (DPLL) architecture, which is based on the arctan phase detector, driving a phase lock loop (PLL) to synchronize a PV generator with the grid voltage. The proposed system has been tested by simulation using Simulink/Matlab. The test results demonstrate the ability of the system to synchronize a PV inverter with the grid and to re-establish synchronization following a sudden perturbation in the grid voltage such as a single or a multi-step change in phase.
Properties of intracellular bovine papillomavirus chromatin (1986)

Episomal nucleoprotein complexes of bovine papillomavirus type 1 (BPV-1) in transformed cells were exposed to DNase I treatment to localize hypersensitive regions. Such regions, which are indicative for gene expression, were found within the noncoding part of the genome, coinciding with the origin of replication and the 5' ends of most of the early mRNAs. However, there were also regions of hypersensitivity within the structural genes. These intragenic perturbations of the chromatin structure coincide with regulatory sequences at the DNA level. One of these regions maps in close proximity to a Z-DNA antibody-binding site which is located near the putative BPV-1 enhancer sequence.
The Relationship Between Microstructure and Ma netic Properties in L1, Ordered Fe-Pd Ferr omag neg (1994)

Electron microscopy has been used to study the microstructural basis for enhanced coercivities in thermomechanically processed FePd ferromagnets exhibiting a fine recrystallized grain structure. The increase in magnetic hardness is attributed to a change in the domain processes which control magnetization reversal compared to those operating in the well-known polytwinned microstructures characteristic of these alloys.
Functional connectivity through nonlinear modeling: An application to the rat hippocampus (2008)

Implementation of neuroprosthetic devices requires a reliable and accurate quantitative representation of the input-output transformations performed by the involved neuronal populations. Nonparametric, data driven models with predictive capabilities are excellent candidates for these purposes. When modeling input-output relations in multi-input neuronal systems, it is important to select the subset of inputs that are functionally and causally related to the output. Inputs that do not convey information about the actual transformation not only increase the computational burden but also affect the generalization of the model. Moreover, a reliable functional connectivity measure can provide patterns of information flow that can be linked to physiological and anatomical properties of the system. We propose a method based on the Volterra modeling approach that selects distinct subsets of inputs for each output based on the prediction of the respective models and its statistical evaluation. The algorithm builds successive models with increasing number of inputs and examines whether the inclusion of additional inputs benefits the predictive accuracy of the overall model. It also explores possible second-order (inter-modulatory) interactions among the inputs. The method was applied to multi-unit recordings from the CA3 (input) and CA1 (output) regions of the hippocampus in behaving rats, in order to reveal spatiotemporal connectivity maps of the input-output transformation taking place in the CA3-CA1 synapse.
Modeling, Simulation, and Experimentation of a Promising New Packaging Technology: Parallel Fluidic Self‐Assembly of Microdevices (2003)

Abstract The parallel fluidic self‐assembly of microdevices is a new technology that promises to speed up the production of complex microsystems made up of many separate parts. The technology brings many advantages. First, it enables a mix of chipmaking technologies for each of the component parts, with each technology selected for its particular technical or financial benefits. Second, it eliminates the need for pick‐and‐place assembly that would unnecessarily slow down any manual assembly technique. Third, it enables massively parallel assembly, almost independent of the number of parts involved, and thereby mimics the elegant parallelism inherent in microchip circuit manufacture. In this chapter we explore this new technology with the ultimate goal of discovering the practical limits for its practical use in manufacturing real microsystems. The driving force of the assembly process is interface surface tension, and our approach is to find the simplest models that correctly describe the attachment, orientation, and bonding of parts to a suitably prepared substrate. We follow both an analytical and a numerical approach in describing the surface tension effects, the latter mainly to gain geometrical generality, and we couple modeling and simulation with suitable laboratory experiments. The ultimate goal of this work is to find practical design rules with which to select bond site geometries and the properties of participating liquids, and to find practical tolerances for all required geometrical and rheological parameters. This chapter extensively documents all results found to date, and carefully cites other work in this area.
Non-enzymatic dynamic kinetic resolution of racemic α-arylalkanoic acids: an advanced asymmetric synthesis of chiral nonsteroidal anti-inflammatory drugs (NSAIDs) (2012)

An efficient protocol was developed to produce chiral 2-arylalkanoic esters in high yields (up to 99%) from racemic carboxylic acids utilizing the racemization of the mixed-anhydrides generated from acid components with pivalic anhydride in the presence of an acyl-transfer catalyst. The present DKR involves the enantio-discriminating esterification of the racemic 2-arylalkanoic acids and the rapid racemization of the chiral 2-arylalkanoic acids under suitable reaction conditions using pivalic anhydride, diisopropylethylamine, and benzotetramisole (BTM) in a polar solvent, and this method was successfully applied for the preparation of pharmacodynamically active (S)-enantiomers of nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen.
Simple reflection anisotropy microscopy set-up for CO oxidation studies (2007)

Reflection anisotropy microscopy (RAM) is a tool to monitor the optical anisotropy of surfaces with spatial resolution (Rotermund et al 1995 Science 270 608–10). It has been applied to pattern formation during CO oxidation on Pt(110), where it provides a high sensitivity for surface reconstruction and partially also for the coverage with reaction educts (Heumann 2000 Dissertation TU-Berlin). However, the spatial resolution of RAM and the alignment procedure of the optical components were not satisfactory. Here, we give a detailed description of a new set-up, which employs a simple polarizing beam splitter cube as an analyser instead of a Foster prism, offering a higher spatial resolution (&lt;10 μm) and easier alignment of the optical components while retaining the high sensitivity for surface structure. Polarization contrast and spatial resolution of the new set-up are systematically measured, and applications to CO oxidation on uniform and microstructured Pt(110) single crystals are presented.