gebhart/patrepeval huggingface dataset:
Inducible CYP2J2 and Its Product 11,12-EET Promotes Bacterial Phagocytosis: A Role for CYP2J2 Deficiency in the Pathogenesis of Crohn’s Disease? (2013)

The epoxygenase CYP2J2 has an emerging role in inflammation and vascular biology. The role of CYP2J2 in phagocytosis is not known and its regulation in human inflammatory diseases is poorly understood. Here we investigated the role of CYP2J2 in bacterial phagocytosis and its expression in monocytes from healthy controls and Crohns disease patients. CYP2J2 is anti-inflammatory in human peripheral blood monocytes. Bacterial LPS induced CYP2J2 mRNA and protein. The CYP2J2 arachidonic acid products 11,12-EET and 14,15-EET inhibited LPS induced TNFα release. THP-1 monocytes were transformed into macrophages by 48h incubation with phorbol 12-myristate 13-acetate. Epoxygenase inhibition using a non-selective inhibitor SKF525A or a selective CYP2J2 inhibitor Compound 4, inhibited E. coli particle phagocytosis, which could be specifically reversed by 11,12-EET. Moreover, epoxygenase inhibition reduced the expression of phagocytosis receptors CD11b and CD68. CD11b also mediates L. monocytogenes phagocytosis. Similar, to E. coli bioparticle phagocytosis, epoxygenase inhibition also reduced intracellular levels of L. monocytogenes, which could be reversed by co-incubation with 11,12-EET. Disrupted bacterial clearance is a hallmark of Crohn's disease. Unlike macrophages from control donors, macrophages from Crohn's disease patients showed no induction of CYP2J2 in response to E. coli. These results demonstrate that CYP2J2 mediates bacterial phagocytosis in macrophages, and implicates a defect in the CYP2J2 pathway may regulate bacterial clearance in Crohn's disease.
Successful Cementing Based on New Design Methodology for Displacement of Non-aqueous Drilling Fluid (2014)

Abstract Drilling fluid removal by spacer fluids is an important step in ensuring proper cementing and therefore adequate zonal isolation, especially when non-aqueous fluids (NAF) are used. In addition to the fluid mechanics aspect of displacement, a tensioactive package containing surfactant(s) and solvent(s) is typically added to the spacer base fluid to clean all surfaces, including the casing. However, current surfactants and solvents on the market have limited application in terms of temperature and type of drilling fluids. API and ISO standards recommend practices for evaluating the suitability of a spacer. The viscosity of NAF, spacer, and cement mixtures at various fixed ratios determines their rheological compatibility. The reverse-emulsion test or spacer-surfactant screening test (SSST) determines the percentage of spacer for inverting the NAF emulsion. Other non-standardized tests such as bottle tests or grid tests determine the efficiency of a surfactant/solvent aqueous solution to remove NAF from metallic or glass surfaces. But all these tests suffer from lack of reproducibility and limited automation. Improved alternative laboratory procedures have already been proposed. They include measuring rheology during SSST, which clearly shows the positive impact of early emulsion inversion on viscosity of NAF/spacer mixtures. In addition, proper preparation of metal surfaces clearly improves repeatability of the cleaning test, which now is performed with weighted spacer under temperature and pressure. Using these improved experimental methods, we performed more than 3,000 different tests on more than 200 tensioactive blends. Statistical analysis helped in selecting the optimum chemistry as a function of the conditions (type of base oil, salinity, and temperature). This allowed developing both guidelines and a tensioactive package comprising a limited number of chemicals (surfactants and solvents), from which the field user would select the ones to combine for the application. Only a few confirmation tests would be necessary at the location for planning a given cement operation. An advantage of developing a package of chemicals is ease of implementation at field level since it requires having only a few chemicals in inventory to cover all situations and limited local laboratory testing. The new methods have been successfully applied in several wells in which different types of nonaqueous fluids were used at various temperatures.
Fabrication of an 8 K active heater feedback superconducting bolometer (2012)

We report on the design and fabrication of an 8 K superconducting transition edge sensor (TES) bolometer with active heater feedback, for applications at far-infrared wavelengths. The bolometer is made using standard micro-fabrication techniques. The expected NEP is better than 1 pW/√ Hz.
Differing clinical features between Japanese and Caucasian patients with myelodysplastic syndromes: Analysis from the International Working Group for Prognosis of MDS (2018)

Clinical features of myelodysplastic syndromes (MDS) could be influenced by many factors, such as disease intrinsic factors (e.g., morphologic, cytogenetic, molecular), extrinsic factors (e.g, management, environment), and ethnicity. Several previous studies have suggested such differences between Asian and European/USA countries. In this study, to elucidate potential differences in primary untreated MDS between Japanese (JPN) and Caucasians (CAUC), we analyzed the data from a large international database collected by the International Working Group for Prognosis of MDS (300 and 5838 patients, respectively). JPN MDS were significantly younger with more severe cytopenias, and cytogenetic differences: less del(5q) and more +1/+1q, -1/del(1p), der(1;7), -9/del(9q), del(16q), and del(20q). Although differences in time to acute myeloid leukemia transformation did not occur, a significantly better survival in JPN was demonstrated, even after the adjustment for age and FAB subtypes, especially in lower, but not in higher prognostic risk categories. Certain clinical factors (cytopenias, blast percentage, cytogenetic risk) had different impact on survival and time to transformation to leukemia between the two groups. Although possible confounding events (e.g., environment, diet, and access to care) could not be excluded, our results indicated the existence of clinically relevant ethnic differences regarding survival in MDS between JPN and CAUC patients. The good performance of the IPSS-R in both CAUC and JP patients underlines that its common risk model is adequate for CAUC and JP.
Full color image reconstruction from single color image utilizing color correlation. (1988)

画像の部分領域におけるRGB信号値の相関性を利用して, RGBのうちの1色を基準とする単色画像によりフルカラー画像を表現する新しい符号化表示法を検討した.本方式によれば, 基準色に選んだほぼ1色分の情報で3色分を表現でき, 解像度が低下しないという特徴がある.基準色画像に他の符号化圧縮法を併用すれば, さらに高圧縮が期待できる.
Magnetic Materials: Photoinduced Magnetization with a High Curie Temperature and a Large Coercive Field in a Co‐W Bimetallic Assembly (Adv. Funct. Mater. 10/2012) (2012)

As reported by Shin-ichi Ohkoshi and co-workers on page 2089 a three-dimensional Co-W bimetallic assembly possessing two different aromatic molecules, [{CoII(4-methylpyridine)(pyrimidine)}2{CoII(H2O)2}{WV(CN)8}2]·4H2O, exhibits a photoinduced magnetization due to an optical charge-transfer-induced spin transition with a high Curie temperature (TC) of 48 K and a gigantic coercive field (HC) of 27 000 Oe. The TC and HC values are the highest reported for photoinduced magnetization systems.
A Phase 1 Dose‐Escalation Study of ASP2409, a Selective T‐Cell Costimulation Inhibitor, in Stable Rheumatoid Arthritis Patients on Methotrexate Therapy (2015)

ASP2409 represents a new class of CTLA4-Ig molecules with higher binding avidity and selectivity to CD86. This first-in-human study was to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of ASP2409 in stable rheumatoid arthritis patients on methotrexate therapy with a randomized, double-blind, placebo-controlled dose-escalation study design. Patients were enrolled and randomized in each of 8 dose-escalation cohorts ranging from 0.001 to 3.0 mg/kg to receive either ASP2409 or placebo in a sequential manner. Escalation to higher dose levels occurred in the absence of dose-limiting toxicity. A total of 57 patients completed the study. ASP2409 showed nonlinear PK over the dose range of 0.01 to 3.0 mg/kg following a single intravenous administration, indicating target-mediated drug disposition. Area under the concentration-time curve (AUC) and maximum concentration (Cmax ) increased at a greater than dose-proportional rate. The half-life of ASP2409 increased dose dependently and ranged from 1.57 to 6.68 days. ASP2409 showed a dose-dependent increase in the extent and duration of CD86 receptor occupancy. There were no clinically relevant safety issues up to a single dose of 3.0 mg/kg. No maximum tolerated dose was reached. The incidence and duration of antidrug antibodies did not correlate with adverse events. ClinicalTrials.gov identifier: NCT02171143.
Dominant-negative mutants M1 and M5 associate with large pre-ribosomal particles (2011)

<b>Copyright information:</b>Taken from "Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex"Nucleic Acids Research 2006;34(10):3030-3043.Published online 31 May 2006PMCID:PMC1474060.© 2006 The Author(s) Western-blot analysis of sucrose gradient fractions of TGR-1 cells expressing Pes1-HA, and Pes1-HA mutants M1, M3 and M5 with an HA-specific antibody. RNA of each fraction was analysed by northern analysis with 28S rRNA specific probe (lower panel).
ChemInform Abstract: Construction of Dihydro‐1,4‐dioxins: Synthesis of Dihydro‐1,4‐dioxin‐3‐carboxanilides. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Enhancing microRNA activity through increased endosomal release mediated by nigericin (2018)

Abstract The therapeutic promise of small RNA therapeutics (siRNAs, miRNAs) is not only limited by the lack of delivery vehicles, but also by the inability of the small RNAs to reach intracellular compartments where they can be biologically active. We previously reported successful delivery of functionally active miRNAs via receptor-mediated endocytosis 1 . This type of targeted therapy still faces one of the major challenges in the delivery field, endosomal sequestration. Here, a new method has been developed to promote endosomal escape of delivered miRNA. The strategy relies on the difference in solute contents between nascent endosomes and the cytoplasm: early endosomes are rich in sodium ions (Na + ) while the intracellular fluid is rich is potassium ions (K + ). Exploiting this difference through favoring the influx of K + into the endosomes without the exchange for a osmotically active ion (Na + ), results in an osmotic differential leading to endosome swelling and bursting. One molecule that is able to exchange K + for an osmotically inactive hydrogen ion is the ionophore nigericin. Via generating an intramolecular miRNA delivery vehicle, containing a ligand, in this case folate, and nigericin we achieve escape of folate-RNA conjugates (e.g. FolamiRs) from their entrapping endosomes into the cytoplasm where they bind the RNA Induced Silencing complex (RISC) and activate the RNAi response.
Poly(aryl ether amides) (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPoly(aryl ether amides)James L. HedrickCite this: Macromolecules 1991, 24, 3, 812–813Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://pubs.acs.org/doi/10.1021/ma00003a027https://doi.org/10.1021/ma00003a027research-articleACS PublicationsRequest reuse permissionsArticle Views216Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry (2019)

Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [11C]CO carbonylative cross-coupling reaction between aryl halides and sulfonamides is presented. Various model compounds as well as drug molecules LY573636 (tasisulam) and ABT-199 were obtained in excellent yields. This method provides a valuable and widely applicable contribution to the continuously expanding radiochemical toolbox for PET research.
Design of RF filters using silicon integrated passive components (2005)

The paper discusses the design and characterization of RF filters in Freescale's 0.4 micron SiGe BiCMOS process. An integration scheme for bandpass filters on a standard silicon substrate using monolithic transformers is presented. A 1.9 GHz filter using a single transformer as well as its dual, where the transformer is replaced by three inductors, is fabricated and measured up to 10 GHz. It is demonstrated that the transformer-based filter occupies less chip area than its inductor-based dual, with similar performance. In addition, results of a 1.7 GHz lowpass (harmonic) filter that exclusively uses high-quality factor (Q) inductors and metal-insulator-metal (MIM) capacitors, designed using scalable models is presented. First pass results show very good agreement between models and measurement.
The chemistry of copper(I)β-diketonate compounds. Part 4. Syntheses and characterization of CuXLn(X =β-diketonate or Cl, L = PMe3, n= 2 or 4; L = PEt3, n= 2) (1992)

The salts [Cu(PMe3)4]+[CuCl2]– and [Cu(PMe3)4]+[β-diketonate]–[β-diketonate = 1,1,1,5,5,5-hexafluoroacetylacetonate (hfacac), 1,1,1-trifluoroacetylacetonate (tfacac) or acetylacetonate (acac)] were prepared by the displacement of the co-ordinating anions Cl– and β-diketonate from the copper(I) complexes [CuX(PMe3)](X = Cl or β-diketonate) by addition of an excess of PMe3. These species were characterized by a variety of spectroscopic methods including 31P NMR spectroscopy which revealed coupling between 31P and 63,65Cu in the cation. Two examples were characterized in the solid state by single-crystal X-ray diffraction: [Cu(PMe3)4]+[CuCl2]–, space group P213, a= 13.584(1)Å and Z= 12; [Cu(PMe3)4]+[hfacac]–, space group Pmmn, a= 10.703(2), b= 15.077(3), c= 8.997(2)Å and Z= 2. The cations exhibit an approximately tetrahedral co-ordination environment and the anion [CuCl2]– is linear. The addition of excess of PEt3 to [CuX(PEt3)] resulted in formation of [CuX(PEt3)2] in contrast to the PMe3 analogues. The compound [CuCl(PEt3)2] was found to be monomeric in benzene solution by cryoscopic molecular weight determination and has high volatility.
The Management of Gastrointestinal Stromal Tumors: A Model for Targeted and Multidisciplinary Therapy of Malignancy (2011)

Gastrointestinal stromal tumor (GIST) has become a model for targeted therapy in cancer. The vast majority of GISTs contain an activating mutation in either the KIT or platelet-derived growth factor A (PDGFRA) gene. GIST is highly responsive to several selective tyrosine kinase inhibitors. In fact, this cancer has been converted to a chronic disease in some patients. Considerable progress has been made recently in our understanding of the natural history and molecular biology of GIST, risk stratification, and drug resistance. Despite the efficacy of targeted therapy, though, surgery remains the only curative primary treatment and cures >50% of GIST patients who present with localized disease. Adjuvant therapy with imatinib prolongs recurrence-free survival and may improve overall survival. Combined or sequential use of tyrosine kinase inhibitors with other agents following tumor molecular subtyping is an attractive next step in the management of GIST.
Population expansion and genomic adaptation to agricultural environments of the soybean looper, Chrysodeixis includens (2020)

Evolutionary studies of insect pests improve our ability to anticipate problems in agricultural ecosystems, such as pest outbreaks, control failures, or expansions of the host range. Here, we investigated the mechanisms underlying the evolutionary processes behind the recent census size expansion and local adaptation of <i>Chrysodeixis includens</i>. First, we sequenced mitochondrial markers to conduct a phylogeographic investigation of <i>C. includens</i> historical processes. Then, we combined a de novo genotyping-by-sequencing approach with a study of agricultural landscapes to uncover recent processes of adaptation. Primarily, we found low genetic diversity across all markers and clear indications of a recent demographic expansion. We also found a lack of significant isolation by distance (IBD), and weak or absent genetic structure considering geographic locations. However, we did find initial signs of population differentiation that were associated with host plant types (i.e., soybean and cotton). Agricultural landscape attributes, including soybean crops, were significantly associated with putative markers under positive selection. Moreover, positive selection associated with host differentiation was putatively linked to digestive enzymes. This study showed how landscape composition and host plants can affect the evolutionary process of agricultural pest insects such as <i>C. includens</i>.
Minimizing the Noise Penalty Due to Mutual Coupling for a Receiving Array (2009)

For phased array receivers, mutual coupling leads to beam-dependent active impedances which must be taken into account when matching the array ports to front end amplifiers for optimal noise performance. We study the noise penalty for several noise matching conditions and develop a matching condition that minimizes the average beam equivalent receiver noise temperature over multiple beams. For non-beamforming applications such as multiple input multiple output communications, we show that noise performance for coupled arrays can be quantified using the spectrum of an equivalent receiver noise temperature correlation matrix.
Engineering a 1:2 Bio-multiplexer for controlled stem cell differentiation (2006)

Precise control of stem cell differentiation offers tremendous potential for tissue engineering. Synthetic gene networks provide a framework for understanding and engineering life. We propose to use synthetic gene networks to engineer circuits that dictate the cell fate of embryonic stem (ES) cells by controlling gene expression. These networks will be capable of turning on cell fate regulator genes in stem cells at precise times and under well-controlled and well-defined conditions based on external stimuli and the internal state of the cell. The over-expression of these cell fate regulator genes is sufficient to trigger particular differentiation path ways in ES cells. We have implemented a lentivirus delivered 1:2 multiplexer circuit for programmed differentiation. This network uses a transactivator, a repressor and one small molecule input Doxycycline (Dox). Dox selects to activate one of two cell fate regulator gene outputs, thereby pushing the ES cell along one of two differentiation pathways. Preliminary results demonstrate the ability to switch between the expression of two fluorescent proteins - EGFP and DsRed-Express based on the external input Dox. Upon integration of the cell fate regulators MyoD and Nanog into this circuit, ES cells will either differentiate into muscle or maintain their undifferentiated state. Characterization of this simple network in mammalian cells is an important first step as this circuit will serve as a basis for building more complex networks that can select between many outputs using only a few inputs to form structures that resemble complex tissues like the spinal cord.
An Energy-Efficient Multi-bit Current-based Analog Compute-In-Memory Architecture and design Methodology (2023)

An energy-efficient and multi-bit (4b) current-based analog compute in-memory (CIM) architecture is proposed in this paper. In current-based analog CIM schemes, multiplication and-accumulate (MAC) operation is performed on bitline, and resultant output is equivalent to bitline voltage drop <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(\Delta \mathbf{V}_{\text{RBL}})$</tex> . However, dependence of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\Delta \mathbf{V}_{\text{RBL}}$</tex> on process, voltage and temperature (PVT) variations and analog non-idealities (ANIs), reduces the signal-to-noise ratio (SNR) of MAC and degrade the computation accuracy of MAC in analog CIM architecture. An analytical model of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\Delta \mathbf{V}_{\text{RBL}}$</tex> to predict the computation accuracy of MAC in current-based analog CIM architecture through a single SPICE simulation is presented in this paper. The proposed model determines the dynamic range of analog input voltage <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(\boldsymbol{V}_{a})$</tex> on the bitline for linear MAC operation for a given technology node. This model also provides a design methodology to predict computation accuracy of MAC and optimize design parameters for current-based analog CIM architecture with the modelling error of 1.1% in SPICE simulations. The implementation of the proposed CIM architecture and model validation are done using a standard 65nm CMOS technology. The proposed architecture achieves <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$13\times$</tex> energy-efficiency and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$2.5\times$</tex> reduction in latency for 4-b multiplication and accumulation (MAC) operation than state-of-the-art. The proposed CIM architecture achieves <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$13\times$</tex> improvement in Figure of Merit (FoM).
Audio Information Extraction (2002)

An overview of the work of the Laboratory for Recognition and Organization of Speech and Audio, Department of Electrical Engineering, Columbia University.
The causes of drug-induced muscle toxicity (2014)

This review provides an overview of the main underlying mechanisms of drug-induced myopathies. These myopathies will most often be related to a drug's ability to alter metabolism and protein balance, induce necrosis, or impair autophagy.