gebhart/patrepeval huggingface dataset:
On estimation of errors caused by non-linear undermodelling in system identification (2002)

The problem of quantifying errors due to non-linear undermodelling is addressed. In particular, the Wiener system which consists of a linear dynamic block followed by a static non-linearity and the Hammerstein system in which the order of these two blocks is reversed are studied. In either case it is assumed that the objective is to identify the linear part of the system using a purely linear model. These scenarios can be interpreted as linear identification applied to systems where non-linearity errors may occur and hence need to be quantified. The stochastic embedding approach is therefore applied to capture the on-average properties of the undermodelling due to inadequate representation of the non-linear effects. As compared to previous methods, the priors on the covariance matrix of the embedding parameters are reduced. As a result an expression for the amplitude error bound of the estimated transfer function, that does not require knowledge of the true system parameters, is obtained. The quality of this measure depends on the degree of accuracy with which the unknown non-linearity can be represented using a set of known polynomials. The proposed method simultaneously delivers error bounds on the estimated transfer function and an indirect estimate of the size of the non-linearity, both quantities being central in controller design.
Abstract 5697: Targeting PARP inhibitor resistance with Polθ inhibitors (2022)

Abstract To target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase function of DNA polymerase Polθ, including ART558. ART558 inhibits the major Polθ-mediated DNA repair process, Theta-Mediated End Joining (TMEJ), without targeting Non-Homologous End Joining. Moreover, we show that exposure to ART558 can elicit DNA damage and synthetic lethality in BRCA1- or BRCA2-mutant tumor cells and enhances the effects of a PARP inhibitor. Genetic perturbation screening revealed that defects in the 53BP1/Shieldin complex, which are a cause of PARP inhibitor resistance, result in in vitro and in vivo sensitivity to Polθ polymerase inhibitors. Mechanistically, ART558 increases biomarkers of single-stranded DNA and synthetic lethality in 53BP1-defective cells. The inhibition of DNA nucleases that promote end-resection, such as Exo1 or Blm-Dna2 reversed these effects, implicating these in the synthetic lethal mechanism-of-action. Taken together, these observations describe a drug class that elicits BRCA-gene synthetic lethality and PARP inhibitor synergy, as well as targeting a biomarker-defined mechanism of PARPi-resistance. Citation Format: Diana Zatreanu, Helen Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luted Badder, Daniela Novo, Eleanor Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Andre Nussenzweig, Marcel Tijsterman, Andrew N. Tutt, Simon Boulton, Geoff Higgins, Stephen J. Pettitt, Graeme C. Smith, Christopher J. Lord. Targeting PARP inhibitor resistance with Polθ inhibitors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5697.
Novel Transceiver Architecture for an Asynchronous Grant-Free IDMA System (2019)

This paper investigates a grant-free non-orthogonal multiple access (NOMA) system where massive number of users wake up and send data right away without performing a grant-based initial access procedure. Since no scheduling grant is used in this system, the base station (BS) does not know which user is transmitting on each resource. Also, due to the lack of an uplink (UL) timing control process, multiple user's signals are asynchronously received at the BS. This causes asynchronous interference, or multiuser inter-carrier and inter-symbol interference. We propose two ideas to address these two problems. We first propose an auxiliary preamble structure to successfully detect the user activity, even in the presence of a massive number of users. We, then, propose a modification to the interleave-division multiple access (IDMA) receiver to mitigate asynchronous interference. The simulation results show that the proposed scheme significantly improves the preamble detection performance and BER performance compared to the conventional schemes. Furthermore, we show that the proposed grant-free NOMA system can achieve much better performance than the grant-based NOMA system in terms of transmission time and signaling overhead.
Recurrent pseudohypopyon in association with primary vitreoretinal lymphoma: a case report (2016)

Pseudohypopyon is one of the signs of recurrent vitreoretinal lymphoma. Although pseudohypopyon was temporarily controlled with intravitreal MTX, this treatment did not completely induce its remission.
`HERON` as a dark matter detector? (1996)

``{bold HERON}``, which is the acronym for `` {bold He}lium: {bold Ro}ton detection of {bold N}eutrinos``, is a project whose principal goal is a next generation detector of solar neutrinos from the p-p and {sup 7}Be branches. It will utilize superfluid helium as the target material and employ event energy transport out of the target by phonon and roton processes unique to helium. Many of the challenges presented for dark matter detection are very similar to those for low energy solar neutrinos. We present new results from our feasibility studies for {bold HERON} which indicate an asymmetry in the roton emission distribution from stopping particles and the ability to detect simultaneously the ultraviolet fluorescence photons also emitted. These features are potentially valuable for solar neutrino detection and the question is explored as to whether or not the same helium technique could be valuable for WIMP dark matter detection.
Development of polycarbonate-containing block copolymers for thin film self-assembly applications (2015)

High quality block copolymers are needed for thin film self-assembly and directed self-assembly applications.
Decoupled reference governors: a constraint management technique for MIMO systems (2021)

This paper presents a computationally efficient solution for constraint management of multi-input and multi-output (MIMO) systems. The solution, referred to as the Decoupled Reference Governor (DRG), maintains the highly-attractive computational features of Scalar Reference Governors (SRG) while having performance comparable to Vector Reference Governors (VRG). DRG is based on decoupling the input–output dynamics of the system, followed by the deployment of a bank of SRGs for each decoupled channel. We present two formulations of DRG: DRG-tf, which is based on system decoupling using transfer functions, and DRG-ss, which is built on state feedback decoupling. A detailed set-theoretic analysis of DRG, which highlights its main characteristics, is presented. We also show a quantitative comparison between DRG and the VRG to illustrate the computational advantages of DRG. The robustness of this approach to disturbances and uncertainties is also investigated.
Fluidity and Microstructure Evolution of Al-12%B<SUB>4</SUB>C Composites Containing Magnesium (2011)

The influence of 0.5% magnesium addition on the fluidity evolution and microstructure of aluminum and Al-12%B4C composites was investigated. It was observed that the magnesium addition reduced the fluidity of aluminum and the Al-B4C composites. Moreover, magnesium promoted the interfacial reactions between liquid aluminum and B4C in the Al-B4C composites. An adequate Ti addition in the composites could effectively limit the impact of magnesium on the interfacial reactions and significantly improve the fluidity by forming a dense TiB2 protective layer on the B4C particle surface. It was also found that a part of magnesium is consumed in the reaction product, which resulted in the reduction of magnesium available in the matrix. The effects of magnesium and titanium on the fluidity, interfacial reactions and magnesium redistribution were discussed.
LCOS-based WSS with true integrated channel monitor for signal quality monitoring applications in ROADMs (2008)

We propose and demonstrate a novel LCOS based WSS architecture with independent operation of two WSS switches in a single optical device to enable cost effective integrated monitoring of signal quality at any desired point in a ROADM. Only a very minor dimensional change to the optical train is required to separate the operation of a number of ports to be used for the monitoring application. The monitor ports can switch independently of the WSS and can even operate on different channel bandwidths or Grids. The independently filtered light path can be made available for power measurements in the first case or for full signal quality measurements.
Validation of High Reynolds Number, Unsteady Multi-Phase CFD Modeling for Naval Applications (2001)

Unsteady, high Reynolds number validation cases for a multi-phase computational fluid dynamics (CFD) analysis tool have been pursued. The tool, designated UNCLE-M, has a wide range of applicability including flows of naval relevance. This includes supercavitating and cavitating flows, bubbly flows, and water entry flows. Thus far the tool has been applied to a variety of configurations. Axisymmetric sheet cavity flow-fields have been modeled. In particular, an attempt to validate the unsteady reliability of UNCLE-M with consideration of the effect of cavitation number, Reynolds number and turbulence model has been made. Analysis of the modeled unsteady flow-field is also made and conclusions regarding the causes of success and shortcomings in the computational results are drawn.
Thermal Activation and Quantum Field Emission in a Sketch-Based Oxide Nano Transistor (2010)

We report direct measurements of the potential barriers and electronic coupling between nanowire segments within a sketch-based oxide nanotransistor (SketchFET) device. Near room temperature, switching is governed by thermally activation across a potential barrier controlled by the nanowire gate. Below T=150 K, a crossover to quantum field emission is observed that is sensitive to structural phase transitions in the SrTiO3 layer. This direct measurement of the source-drain and gate-drain energy barriers is crucial for the development of room-temperature logic and memory elements and low-temperature quantum devices.
Search for the chiral magnetic effect with isobar collisions at sNN=200 GeV by the STAR Collaboration at the BNL Relativistic Heavy Ion Collider (2022)

The chiral magnetic effect (CME) is predicted to occur as a consequence of a local violation of P and CP symmetries of the strong interaction amidst a strong electromagnetic field generated in relativistic heavy-ion collisions. Experimental manifestation of the CME involves a separation of positively and negatively charged hadrons along the direction of the magnetic field. Previous measurements of the CME-sensitive charge-separation observables remain inconclusive because of large background contributions. To better control the influence of signal and backgrounds, the STAR Collaboration performed a blind analysis of a large data sample of approximately 3.8 billion isobar collisions of 9644Ru+9644Ru and 9640Zr+9640Zr at √sNN=200 GeV. Prior to the blind analysis, the CME signatures are predefined as a significant excess of the CME-sensitive observables in Ru+Ru collisions over those in Zr+Zr collisions, owing to a larger magnetic field in the former. A precision down to 0.4% is achieved, as anticipated, in the relative magnitudes of the pertinent observables between the two isobar systems. Observed differences in the multiplicity and flow harmonics at the matching centrality indicate that the magnitude of the CME background is different between the two species. No CME signature that satisfies the predefined criteria has been observed in isobar collisions in this blind analysis.
EPINEPHRINE-INDUCED PULMONARY EDEMA DURING ARTHROSCOPIC KNEE SURGERY (2003)

Mazzocca, Augustus D. MD; Meneghini, R. Michael MD; Chhablani, Ramesh MD; Badrinath, Shyamala K. MD; Cole, Brian J. MDMBA; Bush-Joseph, Charles A. MD Author Information
Circularly Polarized Fabry–Perot Antenna Using a Hybrid Leaky-Wave Mode (2019)

This paper presents the spectral Green's function (GF) to analyze Fabry-Perot antennas to generate circular polarization (CP). The structure consists of a single cavity created between a partially reflective surface and a high impedance surface, fed by a low directive, linearly polarized source. Elements in the antenna are characterized by tensor impedances. It allows conceiving a circularly polarized antenna supporting a single hybrid leaky-wave mode. Residue analysis is used to demonstrate that a single hybrid leaky-wave mode is sufficient to generate CP. The tool is validated by an antenna design matched over a relative bandwidth of 28.5% with an axial ratio lower than 3 dB.
5-Diisopropoxyphosphoryl-5-methyl-1-pyrroline N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO: synthesis and spin trapping propertiesElectronic supplementary information (ESI) available: Tables of crystallographic data. See http://www.rsc.org/suppdata/p2/b2/b206909c/ (2002)

The nitrone DIPPMPO (5-diisopropoxyphosphoryl-5-methyl-1-pyrroline N-oxide) was synthesised, isolated as hygroscopic crystals and its X-ray geometry was determined. The purification of DIPPMPO was easy, compared with that of DEPMPO (5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide) and its solutions in phosphate buffer were EPR silent. DIPPMPO exhibits all the advantages of DEPMPO for the spin-trapping of biological free radicals and thus DIPPMPO is a choice tool in this field.
Strip-electrode ultrasonic arrays for production of asymmetric therapeutic thermal lesions (2002)

The authors are investigating high-intensity ultrasonic beams shaped to produce thermal lesions with asymmetric cross-sections. The desired lesions are broad in one cross-sectional dimension; this permits the therapy transducer to be scanned in the orthogonal direction in order to treat large tumor volumes with closely packed lesion matrices. The authors have conducted initial theoretical studies relevant to the formation of such lesions, and they have constructed suitable therapeutic arrays that employ spherical focussing with parallel strip electrodes. In-vitro studies in liver and the ocular lens have demonstrated that the desired lesion geometry can be achieved.
What Galileo And Newton Started (1998)

RETURN TO ISSUEPREVBook ReviewNEXTWhat Galileo And Newton StartedRICHARD N. ZARECite this: Chem. Eng. News 1998, 76, 24, 35–36Publication Date (Print):June 15, 1998Publication History Published online16 November 2010Published inissue 15 June 1998https://pubs.acs.org/doi/10.1021/cen-v076n024.p035https://doi.org/10.1021/cen-v076n024.p035book-reviewACS PublicationsCopyright © 1998 AMERICAN CHEMICAL SOCIETYArticle Views15Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Silver Get e-Alerts
Corrole−Fullerene Dyads: Formation of Long-Lived Charge-Separated States in Nonpolar Solvents (2008)

The first example of covalently linked free-base corrole-fullerene dyads is reported. In the newly synthesized dyads, the free-energy calculations performed by employing the redox and singlet excited-state energy in both polar and nonpolar solvents suggested the possibility of electron transfer from the excited singlet state of corrole to the fullerene entity. Accordingly, steady-state and time-resolved emission studies revealed efficient fluorescence quenching of the corrole entity in the dyads. Further studies involving femtosecond laser flash photolysis and nanosecond transient absorption studies confirmed electron transfer to be the quenching mechanism, in which the electron-transfer product, the fullerene anion radical, was able to be spectrally characterized. The rate of charge separation, kCS, was found to be on the order of 10(10)-10(11) s(-1), suggesting an efficient photoinduced electron-transfer process. Interestingly, the rate of charge recombination, kCR, was slower by 5 orders of magnitude in nonpolar solvents, cyclohexane and toluene, resulting in a radical ion-pair lasting for several microseconds. Careful analysis of the kinetic and thermodynamic data using the Marcus approach revealed that this novel feature is due to appropriately positioning the energy level of the charge-separated state below the triplet states of either of the donor and acceptor entities in both polar and nonpolar solvents, a feature that was not evident in donor-acceptor dyads constructed using symmetric tetrapyrroles as electron donors.
Three-Phase Modal Noise Analysis and Optimal Three-Phase Power Line Filter Design (2023)

Conducted emissions (CE) for three-phase systems are becoming an increasing concern due to the recent exponential growth of three-phase applications, especially linked to the automotive sector. The problem arises because electromagnetic compatibility (EMC) standards only define the methodology to measure the CE generated by the equipment under test (EUT), and they do not provide sufficient information to design a power line filter (PLF) in case of non-compliance. Hence, the design of an optimal PLF is a very difficult task for engineers. The unclear methodology to be followed, unknown load impedances, inadequate equipment, and lack of knowledge of the modal noise are all different reasons that contribute to increasing the PLF design complexity. Common mode (CM) and differential mode (DM) decomposition and PLF design techniques for single-phase EUTs are well discussed and studied in the literature, but the same cannot be stated when it comes to three-phase PLF design. The objective of this paper is to clarify how modal noises behave in a three-phase system and to propose a clear methodology which can be followed to design an optimal three-phase PLF. Additionally, this paper analyses and discusses the modal noises’ intrinsic behavior and provides an understanding of how the PLF components behave when subjected to either a CM or DM noise. Finally, a methodology to design a three-phase PLF, based on accurate insertion loss (IL) estimations and S-parameter measurements, is used to determine the optimal PLF. This approach is tested and validated.
Teaching Synthetic Biology, Bioinformatics and Engineering to Undergraduates: The Interdisciplinary Build-a-Genome Course (2008)

A major challenge in undergraduate life science curricula is the continual evaluation and development of courses that reflect the constantly shifting face of contemporary biological research. Synthetic biology offers an excellent framework within which students may participate in cutting-edge interdisciplinary research and is therefore an attractive addition to the undergraduate biology curriculum. This new discipline offers the promise of a deeper understanding of gene function, gene order, and chromosome structure through the de novo synthesis of genetic information, much as synthetic approaches informed organic chemistry. While considerable progress has been achieved in the synthesis of entire viral and prokaryotic genomes, fabrication of eukaryotic genomes requires synthesis on a scale that is orders of magnitude higher. These high-throughput but labor-intensive projects serve as an ideal way to introduce undergraduates to hands-on synthetic biology research. We are pursuing synthesis of Saccharomyces cerevisiae chromosomes in an undergraduate laboratory setting, the Build-a-Genome course, thereby exposing students to the engineering of biology on a genomewide scale while focusing on a limited region of the genome. A synthetic chromosome III sequence was designed, ordered from commercial suppliers in the form of oligonucleotides, and subsequently assembled by students into approximately 750-bp fragments. Once trained in assembly of such DNA "building blocks" by PCR, the students accomplish high-yield gene synthesis, becoming not only technically proficient but also constructively critical and capable of adapting their protocols as independent researchers. Regular "lab meeting" sessions help prepare them for future roles in laboratory science.
A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB. (1989)

The NF-kappaB transcription factor was affinity-purified from deoxycholate (DOC)-treated cytosol of HeLa cells and shown to contain both a 50-kappaD polypeptide (p50) with a DNA-binding specificity identical to that of nuclear NF-kappaB and a 65-kappaD protein (p65) lacking DNA binding activity. Electrophoretically purified p50, after renaturation, gave rise to a protein-DNA complex that migrated faster than that made by native NF-kappaB. Reconstitution of p50 and p65 together produced a protein that combined with DNA to form a complex with electrophoretic mobility indistinguishable from that of the complex formed by nuclear extracts and DOC-treated cytosolic fractions. Sedimentation and gel filtration analyses indicate that alone, the p50 protein exists as a dimer; two molecules of p65 bind to it to form a heterotetramer. Unlike I kappaB, the specific inhibitor of NF-kappaB, p65 displayed no inhibitor activity and was not released from NF-kappaB by DOC. p65 did not change the DNA binding specificity or the stimulatory effect of GTP on the p50 homodimer. Surprisingly, NF-kappaB could only be inactivated by I kappaB when p65 was bound. It would appear that one function of p65 is to make NF-kappaB susceptible to inhibition by I kappaB.
Laparoscopic nephrectomy for renal cell cancer: evaluation of efficacy and safety: a multicenter experience (1998)

The laparoscopic surgical management of localized renal cell carcinoma is feasible. Short-term results indicate that laparoscopic radical nephrectomy is not associated with an increased risk of port site or retroperitoneal recurrence. Longer follow-up is necessary to compare long-term survival and disease-free rates with those of open surgery.