gebhart/patrepeval huggingface dataset:
Loss of TIP1;1 aquaporin in Arabidopsis leads to cell and plant death (2004)

Summary Arabidopsis TIP1;1 ( γ TIP) is a member of the tonoplast family of aquaporins (AQP). Using RNA interference (RNA i ) we reduced TIP1;1 to different extent in various lines. When most severely affected, miniature plants died, a phenotype partially complemented by the TIP1;1 homolog Mc MIP‐F. Less severely affected lines produced small plants, early senescence, and showed lesion formation. The relative water content in TIP1;1 RNAi plants was not significantly affected. Global expression profiling suggested a disturbance in carbon metabolism in RNAi lines with upregulated transcripts for functions in carbon acquisition and respiration, vesicle transport, signaling and transcription, and radical oxygen stress. Metabolite profiles showed low glucose, fructose, inositol, and threonic, succinic, fumaric, and malic acids, but sucrose levels were similar to WT. Increased amounts were found for raffinose and several unknown compounds. TIP1;1 RNAi plants also contained high starch and apoplastic carbohydrate increased. A GFP‐TIP1;1 fusion protein indicated tonoplast location in spongy mesophyll cells, and high signal intensity in palisade mesophyll associated with vesicles near plastids. Signals in vascular tissues were strongest not only in vesicle‐like structures but also outlined large vacuoles. Compromised routing of carbohydrate and lack of sucrose provision for cell‐autonomous functions seems to characterize this RNAi phenotype. We suggest a function for TIP1;1 in vesicle‐based metabolite routing through or between pre‐vacuolar compartments and the central vacuole. Phenotype and expression characteristics support a view of TIP1;1 functioning as a marker for vesicles that are targeted to the central vacuole.
THE CLINICAL RESPONSE OF GNOTOBIOTIC CALVES, PIGS AND LAMBS TO INOCULATION WITH HUMAN, CALF, PIG AND FOAL ROTAVIRUS ISOLATES (1980)

The infectivity, pathogenicity and immunogenicity of 5 human, 6 calf, 2 pig and 2 foal rotavirus isolates were studied in gnotobiotic calves, piglets and lambs. Three of the human isolated produced subclinical infection in newborn gnotobiotic piglets and the piglets developed neutralising antirotavirus antibody. When challenged with pig rotavirus 2 weeks later, the piglets did not develop diarrhoea, but rotavirus was detected in the faeces. In contrast, piglets inoculated with the other 2 human isolates failed to show evidence of infection and there was no specific antibody detected. These piglets developed diarrhoea when challenged 2 weeks later with pig rotavirus. The 4 human isolated failed to infect gnotobiotic calves an lambs.
Technical design considerations of a human-scale Talbot-Lau interferometer for dark-field CT (2022)

&lt;p&gt;Computed tomography (CT) as an important clinical diagnostics method can profit from extension with dark-field imaging, as it is currently restricted to X-rays' attenuation contrast only. Dark-field imaging allows access to more tissue properties, such as micro-structural texture or porosity. The up-scaling process to clinical scale is complex because several design constraints must be considered. The two most important ones are that the finest grating is limited by current manufacturing technology to a 4.8µm period and that the interferometer should fit into the CT gantry with minimal modifications only. In this work we discuss why an inverse interferometer and a triangular G1 profile are advantageous and make a compact and sensitive interferometer implementation feasible. Our evaluation of the triangular grating profile reveals a deviation in the interference pattern compared to standard grating profiles, which must be considered in the subsequent data processing. An analysis of the grating orientation demonstrates that currently only a vertical layout can be combined with cylindrical bending of the gratings. We also provide an in-depth discussion, including a new simulation approach, of the impact of the extended X-ray source spot which can lead to large performance loss and present supporting experimental results. This analysis reveals a vastly increased sensitivity to geometry and grating period deviations, which must be considered early in the system design process.&lt;/p&gt;
Correction to “Targeted Theranostic 111In/Lu-Nanotexaphyrin for SPECT Imaging and Photodynamic Therapy” (2022)

ADVERTISEMENT RETURN TO ISSUEPREVAddition and Correct...Addition and CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to “Targeted Theranostic 111In/Lu-Nanotexaphyrin for SPECT Imaging and Photodynamic Therapy”Miffy H. Y. ChengMiffy H. Y. ChengMore by Miffy H. Y. Cheng, Marta OverchukMarta OverchukMore by Marta Overchuk, Maneesha A. RajoraManeesha A. RajoraMore by Maneesha A. Rajora, Jenny W. H. LouJenny W. H. LouMore by Jenny W. H. Lou, Ying ChenYing ChenMore by Ying Chen, Martin G. PomperMartin G. PomperMore by Martin G. Pomperhttps://orcid.org/0000-0001-6753-3010, Juan ChenJuan ChenMore by Juan Chen, and Gang Zheng*Gang ZhengMore by Gang Zhenghttps://orcid.org/0000-0002-0705-7398Cite this: Mol. Pharmaceutics 2023, 20, 1, 783Publication Date (Web):November 9, 2022Publication History Received27 October 2022Published online9 November 2022Published inissue 2 January 2023https://doi.org/10.1021/acs.molpharmaceut.2c00905Copyright © 2022 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views263Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (713 KB) Get e-AlertsSUBJECTS:Optical imaging,Photodynamic therapy,Single photon emission computed tomography,Theranostics Get e-Alerts
Convenient One‐Pot Preparation of Dimethyl Bicyclo[2.2.2]octane‐1,4‐dicarbolylate, a Key Intermediate for a Novel Adenosine A1 Receptor Antagonist (2007)

Abstract Dimethyl bicyclo[2.2.2]octane‐1,4‐dicarboxylate (4), a key starting material for a novel adenosine A1 receptor antagonist, was prepared in a one‐pot reaction with convenient workup and improved yield.
Nonlinear dynamic elements with noisy sinusoidal forcing: Enhancing response via nonlinear coupling (1995)

We consider a network of nonlinear dynamic elements with nonlinear, global coupling, subject to noise and a time-periodic signal. The system response, characterized by its signal-to-noise ratio, is computed via approximate analytic techniques and precise numerical simulations. We find that cooperative effects arising from the noise and coupling lead to an enhancement of the response of the network over that of a single element.
Spatial mapping of human lung tissue reveals granuloma diversity and histopathological superstructure in tuberculosis (2022)

Summary The histopathological hallmark of tuberculosis (TB) is the formation of immune cell enriched aggregates called granulomas, but the scope of granuloma heterogeneity in human TB is unknown. By spatially mapping individual immune cells across large regions of TB lung tissue, we report that in addition to necrotizing granulomas, the human TB lung contains abundant non-necrotizing leukocyte aggregates surrounding areas of necrotizing tissue. These cellular lesions were more diverse in composition than necrotizing lesions and could be stratified into four general classes based on cellular composition and spatial distribution of B cells and macrophages, indicating there are foci of distinct immune reactions adjacent to necrotizing granulomas. We further show that the specific cellular composition of non-necrotizing structures correlates with their proximity to necrotizing lesions. Together, our study shows that during tuberculosis diseased lung tissue develops a histopathological superstructure comprising at least four different types of non-necrotizing cellular aggregates organized as satellites of necrotizing granulomas.
Bis-o-diynylarene (BODA) Derived Polynaphthalenes as Precursors to Glassy Carbon Microstructures (1999)

Bis-o-diynylarene (BODA) monomers polymerize by a step growth addition type mechanism providing branched polynaphthalene oligomers which contain reactive o-diyne terminal groups. The reactive oligomers have been successfully melt micromolded using the MIMIC protocol. Microstructures are carbonized to electrically conductive glassy carbon at 1000 °C. The highly aromatic nature of the precursor thermoset offers a high-yield route to glassy carbon microstructures with <25% weight loss by TGA and ca. 15% linear shrinkage of the microstructures by SEM.
Characteristic Validation and Performance Evaluation of Vertical Seismic Isolator with Link-crank Mechanism (2020)

Seismic isolation is an effective way to reduce damage caused by earthquakes. One of the mainstream seismic isolation systems is seismic isolation rubber. This system isolates horizontal vibration but doesn’t isolate vertical vibration. In recent years, earthquakes with large vertical vibrations have been reported. Therefore, we need the seismic isolation device that can be isolated in the vertical direction. A vertical seismic isolation device of the previous study had the problems that it was soft in the vertical direction and bad response to disturbance. Also, the horizontal vibration affects the vertical seismic isolation performance. In this study, we propose a seismic isolation device that solves the problems of the previous research and verify its characteristics and evaluate its performance. To verify its characteristics, we model the device using SimulationX. In the new seismic isolation device, the rigidity of the device can be changed by the motor drive. Also, to decrease horizontal vibration of the device, three link mechanisms are concentrically arranged at equal intervals. This device can set the natural frequency low by the negative rigidity mechanism. We performed three tests to verify its characteristics and evaluate its performance. In the damping free vibration test, we found that the amplitude difference between the experiment and the simulation is different in the upper and lower sides when we considered the equilibrium height as a reference. In the vibration test, we confirmed sufficient seismic isolation effect in multiple seismic waves. In the resonance avoidance test, we confirmed that the device avoids the resonance by the motor drive.
A Digital Fractional-N PLL With a PVT and Mismatch Insensitive TDC Utilizing Equivalent Time Sampling Technique (2013)

A 6-bit time-to-digital converter that achieves mismatch free operation by using a single delay cell and sampling flip-flop is presented. The proposed TDC was integrated in a digital fractional-N PLL fabricated in a 32-nm digital SoC CMOS process for WiFi/WiMax radios. The TDC consumes 3 mW from a 1.05-V supply and occupies an area of 0.004 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . A digital frequency-locked loop is used to track and correct for PVT variations in the TDC and no additional linearization or mismatch calibrations are required. The DPLL uses a 20-bit high dynamic range DAC to drive a VCO in order to effectively realize a DCO with 100-Hz frequency resolution. The 2.5-GHz WiFi band LO output is generated from a 40-MHz reference with an integrated phase noise of - 35 dBc (10 kHz to 10 MHz) while consuming 21 mW . The worst case spur in the LO output is below - 50 dBc without requiring TDC mismatch and linearity calibration.
Supplementary Figure from Anti-spike T-cell and Antibody Responses to SARS-CoV-2 mRNA Vaccines in Patients with Hematologic Malignancies (2023)

Supplementary Figure from Anti-spike T-cell and Antibody Responses to SARS-CoV-2 mRNA Vaccines in Patients with Hematologic Malignancies
Overexpression of poly(ADP-ribose) polymerase promotes cell cycle arrest and inhibits neutrophilic differentiation of NB4 acute promyelocytic leukemia cells. (1996)

The t(15;17) translocation causes a disruption of the retinoic acid receptor alpha (RAR-alpha) and allows for the expression of the PML-RAR alpha fusion protein considered to be responsible for the differentiation block in acute promyelocytic leukemia (APL). Patients being treated with all-trans retinoic acid (ATRA) undergo remission due to the differentiation of leukemic cells to functional neutrophils but relapse due to subsequent ATRA resistance. Our group has shown recently that NB4 cells, the only in vitro model of APL, are capable of monocytic differentiation in response to 1,25-dihydroxyvitamin D3 and 12-O-tetradecanoylphorbol-13-acetate in addition to the neutrophilic differentiation response that occurs with ATRA treatment. Poly(ADP-ribose) polymerase (PARP) is a ubiquitous protein that plays a role in DNA metabolism and repair. We have shown that, unlike HL-60 cells, NB4 cells completely down-regulate PARP in the neutrophilic lineage and up-regulate PARP 90-fold in the monocytic lineage. To ascertain whether PARP is an active participant in the bipotent differentiation of APL cells, NB4 cells were transiently transfected by lipid-mediated gene transfer with the human PARP gene under the control of the human metallothionein promoter. A 4-fold overexpression of PARP, in response to 8 microM CdCl2, promoted arrest of NB4 cells in the S phase of the cell cycle. Overexpression of PARP alone had no effect on cell viability or induction of phenotypic markers in the monocytic or neutrophilic lineages. However, increased PARP expression did result in an increase in the number of cells in the subdiploid population likely to include apoptotic cells. Overexpression of PARP, alone with 12-O-tetradecanoylphorbol-13-acetate (200 nM), 1,25-dihydroxyvitamin D3 (200 nM), or a suboptimal dose of the combined agents, did not alter the expected monocytic differentiation marker profile over cells transfected with control plasmid (pSV2Neo). In contrast, PARP overexpression blocked the appearance of phenotypic markers of terminally differentiated neutrophils in 85% of the transfected population in response to 1 microM ATRA. Comparable to wild-type NB4 cells, 90% of cells transfected with pSV2Neo developed neutrophilic differentiation markers (nitroblue tetrazolium-positive and multi-lobed nuclei) in response to 1 microM ATRA. These data suggest that overexpression of PARP arrests APL cells and blocks ATRA-induced terminal neutrophilic differentiation. We propose that normal down-regulation of PARP in NB4 cells is a requirement for neutrophilic maturation.
A Simple Biomarker to Exclude the Presence of Low Grade Inflammation in Apparently Healthy Individuals (2002)

By using this inexpensive and rapid assessment, we could clearly discriminate between individuals with a very low inflammatory response and those with a more intense one. This biomarker should be further evaluated as a possible screening test for use in large populations of apparently healthy individuals in whom the detection of low grade inflammation might contribute to guiding appropriate lifestyle modifications and therapeutic interventions.
Effects of biomass type, carbonization process, and activation method on the properties of bio-based activated carbons (2018)

Activated carbons (AC) serve as adsorbents in various applications requiring specific functionalities. In this study, the effects of biomass type, pre-carbonization process, and activation method on the properties of ACs were investigated. Chemical (KOH and H3PO4) and physical (CO2) activations were performed on slow pyrolyzed and hydrothermally carbonized (HTC) biochars produced from two feedstocks, willow and Scots pine bark (SPB). In addition, the adsorption capacities of the ACs were tested with two dyes and zinc metal. Distinct differences were found between the biochars and ACs regarding pore size distributions, surface area (238 – 3505 m2 g-1), and surface chemistry. KOH activation produced highly microporous ACs from all biochars, whereas with H3PO4 and CO2 there was also increase in the meso- and macroporosity with the HTC biochars. Adsorption capacity for dyes was dependent on the surface area, while for zinc it depended on AC’s pH. The results provide interesting insights into tailoring ACs for specific applications.
Why do people use portable air purifiers? Evidence from occupant surveys and air quality monitoring in homes in three European cities (2021)

One of the most widely available technologies to clean the air in homes of particulate matter of less than 2.5 µm in diameter (PM2.5), known to have negative health impacts, are portable home air purifiers (HAPs). This paper presents research which (1) explored the effectiveness of HAPs in real-world conditions in 57 homes in three European cities; (2) examined if HAPs affect users' perceptions of the indoor air quality (IAQ) at home; and (3) considered the motivations for occupants' operation of HAPs. Results from this study found that PM2.5 concentrations in bedrooms were reduced by 45% to 69%; perceptions of IAQ were not correlated with measured high PM2.5 levels; occupants reported the HAPs to have a 'cooling' effect, which may explain why the predominant driver of HAP use was thermal comfort, rather than IAQ, in all three cities. The latter finding was supported by a statistically significant increase in the probability of HAP use with increasing indoor temperatures. If the operation of HAPs can be managed, or fully automated, to reflect indoor air pollution levels rather than thermal conditions, better pollutant reduction would be feasible and their use to reduce PM2.5 may help mitigate the negative health effects of exposure whilst at home.
Sensors in Combinatorial Polymer Research (2003)

Abstract Summary: This review highlights the broad potential of sensor technologies for combinatorial polymer research. Advances in components microfabrication, electronics, transducers, and data analysis in the area of sensors can stimulate the development of many more new concepts applicable for rapid polymer screening. These advances are already impacting on several phases in a typical combinatorial discovery cycle that include parallel synthesis of polymers, their performance testing, evaluation of properties, and processing of collected data. It is demonstrated that sensors provide an attractive addition to the infrastructure of the analytical instruments used for screening of intrinsic and performance polymer properties. Impact of sensor technologies on the combinatorial discovery cycle. magnified image Impact of sensor technologies on the combinatorial discovery cycle.
Compliant glass–polymer hybrid single ion-conducting electrolytes for lithium batteries (2020)

This study describes hybrid single ion-conducting electrolytes based on inorganic sulfide glasses and perfluoropolyether polymers for lithium batteries. Herein, it is shown that hybrid electrolytes provide a compelling alternative to the traditional glass, ceramic, or polymer battery electrolytes. These electrolytes present high transference numbers, unprecedented ionic conductivities at room temperature, and excellent electrochemical stability, and they limit the dissolution of lithium polysulfides. The results in this work represent a significant step toward addressing the challenges of enabling the next generation cathodes, such as lithium nickel manganese cobalt oxide and sulfur.
Determination of orientation of the ground state using two-photon nonresonant excitation (1988)

A method is presented for determining the population A{0}0+, the alignment factors A{2}q± and A{4}q ±, and the orientation factors A{1}q± and A{3}q± for a ground state distribution of diatomic (symmetric top) molecules probed by elliptically polarized two-photon nonresonant excitation. General expressions are developed for the O, P, Q, R, and S branch transitions as a function of the rotational quantum number, J. This treatment assumes that the resonant state reached by the two-photon transition is subsequently detected independent of its orientation and alignment. This can be achieved by 2+n multiphoton ionization in which the ionization steps are saturated, or by 2+1 laser induced fluorescence in which the fluorescence is collected independent of its polarization and spatial anisotropy. For the case where elliptically polarized light is created by passing linearly polarized light through a quarter-wave plate, the alignment and orientation moments can be independently determined using a single experimental excitation–detection geometry.
ChemInform Abstract: Characterization and Photochemistry of the Gallium and Indium Subhydrides Ga2H2 and In2H2. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Bilinear hereditary differential systems: State space models in Hilbert space (1976)

We analyze here state space models for bilinear hereditary differential systems of various levels of complexity. It is shown that for many reasons it is more convenient to develop state space models in Hilbert spaces, following the method of Delfour and Mitter. In certain cases explicit bilinear operational differential equations are obtained that illustrate the way the controls influence the spectrum of the infinitesimal generator of the system. Certain connections with the theory of Lie semigroups are also discussed.
GDN-2 TRANSMISSION ERROR CALCULATION FROM TOOTH TOPOGRAPHY DATA AND COMPARISON TO EXPERIMENTAL RESULTS ON SPUR GEARS(GEAR DYNAMICS AND NOISE) (2001)

A test rig for the measurement of transmission error under load on cylindrical gearsets was built. The specific design features allowed to measure the Dynamic Transmission Error (DTE) bypassing traslational vibrations. Tests on spur gears in several torque and speed conditions were conducted and the behavior was evaluated. Before each test the topography of the gear pair was measured by an 8^*8 grid sampling on 4 teeth on both pinion and gear. Employing an analytical calculation tool that accounts from microgeometric topography variations, the Static Transmission Error (STE) was calculated for any possible combination of pinion and gear teeth : calculations show that a wide variation of STE between these results may exist : some combinations of profiles are providing STE amplitudes five times higher the results of other combinations. A further comparison with DTE measurements showed that in low speed tests, near to a quasi-static condition, the difference between calculations and experimental results is slight ; as expected, for higher speeds, the calculation results are generally higher than the measurements.