gebhart/patrepeval huggingface dataset:
Géométrie différentielle et vision par ordinateur : détection et reconstruction des contours d'occultation de la surface d'un objet non-polyédrique (1990)

This paper describes an active vision system based reverse engineering approach to extract the three-dimensional (3D) geometric information from dental teeth and transfer this information into Computer-Aided Design/Computer-Aided Manufacture (CAD/CAM) systems to improve the accuracy of 3D teeth models and at the same time improve the quality of the construction units to help patient care. The vision system involves the development of a dental vision rig, edge detection, boundary tracing and fast & accurate 3D modeling from a sequence of sliced silhouettes of physical models. The rig is designed using engineering design methods such as a concept selection matrix and weighted objectives evaluation chart. Reconstruction results and accuracy evaluation are presented on digitizing different teeth models.
Genome-Wide Expression Analysis Indicates that FNR ofEscherichia coliK-12 Regulates a Large Number of Genes of Unknown Function (2005)

The major regulator controlling the physiological switch between aerobic and anaerobic growth conditions in Escherichia coli is the DNA binding protein FNR. To identify genes controlled by FNR, we used Affymetrix Antisense GeneChips to compare global gene expression profiles from isogenic MG1655 wild-type and Deltafnr strains grown in glucose minimal media under aerobic or anaerobic conditions. We found that 297 genes contained within 184 operons were regulated by FNR and/or by O2 levels. The expression of many genes known to be involved in anaerobic respiration and fermentation was increased under anaerobic growth conditions, while that of genes involved in aerobic respiration and the tricarboxylic acid cycle were repressed as expected. The expression of nine operons associated with acid resistance was also increased under anaerobic growth conditions, which may reflect the production of acidic fermentation products. Ninety-one genes with no presently defined function were also altered in expression, including seven of the most highly anaerobically induced genes, six of which we found to be directly regulated by FNR. Classification of the 297 genes into eight groups by k-means clustering analysis indicated that genes with common gene expression patterns also had a strong functional relationship, providing clues for studying the function of unknown genes in each group. Six of the eight groups showed regulation by FNR; while some expression groups represent genes that are simply activated or repressed by FNR, others, such as those encoding functions for chemotaxis and motility, showed a more complex pattern of regulation. A computer search for FNR DNA binding sites within predicted promoter regions identified 63 new sites for 54 genes. We suggest that E. coli MG1655 has a larger metabolic potential under anaerobic conditions than has been previously recognized.
Identification of composite materials elastic moduli from Lamb wave velocities measured with single sided, contactless ultrasonic method (2001)

The identification of the elastic properties of composite materials is done from measured phase velocities of Lamb waves. In the purpose to set up an industrial, contactless and single-sided access device for in service inspection of aircrafts, air-coupled, capacitive transducers are used to generate and receive Lamb waves which are sensitive to material properties. The set of phase velocities corresponding to at least three modes over a large frequency domain, is used as data to recover the elastic moduli through a minimization algorithm. The system is tested for anisotropic composite materials made of epoxy matrix reinforced by glass or carbon fibers.
Chapter 26 Low-Level Laser and Experimental Aortic Aneurysm (2016)

Low-level laser (light) therapy (LLLT) for traumatic events thatcause brain damage is currently an experimental concept. Thebroad goals for clinical utilization are the prevention of braindamage, relief of symptoms, and stimulation of the repair process.Experimental studies have tested and continue to test these goalsby investigating LLLT in animal models of stroke and traumaticbrain injury (TBI). Animal studies of tLLLT for ischemic strokehave been summarized in this chapter. Studies by other groupson LLLT in mouse TBI models have been discussed. Four studiesfrom our laboratory have been described. The ﬁrst study looked atpulsed versus continuouswave (CW) laser irradiation in a controlledcortical impact (CCI)-TBI model and found pulsed 810 nm laser at10 Hz to be superior. The second study looked at four diﬀerentlaser wavelengths (660, 730, 810, and 980 nm) in a closed-headTBI model; only 660 nm and 810 nm were eﬀective. The third studylooked at diﬀerent treatment repetition regimens (1, 3, and 14 dailylaser treatments). The last study used immunoﬂuorescence tech-niques to show that neurogenesis, brain-derived neurotrophic factor(BDNF), and synaptogenesis were upregulated after transcranialLLLT (tLLLT) for TBI. Limitations in knowledge are still apparent,such as the optimal wavelength, light source, doses, pulsed orCW, polarization state, treatment timing, and repetition frequency.Collaborative eﬀorts between clinicians and basic researchers willlikely increase the usage and understanding of eﬀective laser-basedtherapies in the central nervous system (CNS).
965: Construct and Predictive Validity Testing of the Lapmentor™ Laparoscopic Surgical Simulator (2007)

higher mean Vicryl holding strength (1 0.14..2.46 N) compared to Monocryl (7.70..1.31 N, p=0.02) and PDS (7.09..1.48 N, p<0.01). In every case, Lapra-Tys held stronger to 2-0 suture than to other sizes of the same suture type, though statistical significance was only shown with 2-0 Vicryl suture (13.87..0.79 N) versus 0 and 4-0 Vicryl suture (8.42..0.85 N, p<0.01 and 8.09..0.42 N, p=0.03, respectively). In the tissue trials, the mean displacement was significantly better for Vicryl suture (21.03..6.27 mm) compared to Monocryl (38.47..6.13 mm, p<0.01) and PDS (30.39..11.39 mm, p<0.01 ). The most common mechanism of failure for Vicryl suture was an intact Lapra-Ty pulling through the tissue without slippage in 75% of the trials. The Lapra-Ty slipping off the suture occurred in 66% of Monocryl and PDS trials.
Maximizing yield in Near-Threshold Computing under the presence of process variation (2013)

Near-Threshold Computing (NTC) shows potential to provide significant energy efficiency improvements as it alleviates the impact of leakage in modern deep sub-micron CMOS technology. As the gap between supply and threshold voltage shrink, however, the energy efficiency gains come at the cost of device performance variability. Thus, adopting near-threshold in modern CAD flows requires careful consideration when addressing commonly targeted objectives. We propose a process variation-aware near-threshold voltage (PV-N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">vt</sub> ) gate sizing framework for minimizing power subject to performance yield constraints. We evaluate our approach using an industrial-flow on a set of modern benchmarks. Our results show our method achieves significant improvement in leakage power, while meeting performance yield targets, over a state-of-the-art method that does not consider near-threshold computing.
The application of dispersion relations (Hilbert transforms) to phase retrieval (1974)

A method is given for the retrieval of phase from amplitude information using the Hilbert transform, without the need for evaluating Blaschke factors.
Nonsteroidal Selective Glucocorticoid Modulators:  the Effect of C-5 Alkyl Substitution on the Transcriptional Activation/Repression Profile of 2,5-Dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines (2001)

The preparation and characterization of a series of selective glucocorticoid receptor modulators are described. The preliminary structure-activity relationship of nonaromatic C-5 substitution on the tetracyclic quinoline core showed a preference for small lipophilic side chains. Proper substitution at this position maintained the transcriptional repression of proinflammatory transcription factors while diminishing the transcriptional activation activity of the ligand/glucocorticoid receptor complex. The optimal compounds described in this study were the allyl analogue 18 and cyclopentyl analogue 32. These candidates showed slightly less potent, highly efficacious E-selectin repression with significantly reduced levels of glucocorticoid response element activation in reporter gene assays vs prednisolone. Allyl analogue 18 was evaluated in vivo. An oral dose of 18 showed an ED(50) = 1.7 mg/kg as compared to 1.2 mg/kg for prednisolone in the Sephadex-induced pulmonary eosinophilia model and an ED(50) = 15 mg/kg vs 4 mg/kg for prednisolone in the carrageenan-induced paw edema model.
Parallel graph algorithms (1984)

This paper presents new paradigms to solve efficiently a variety of graph problems on parallel machines. These paradigms make it possible to discover and exploit the parallelism inherent in many classical graph problems. We abandon attempts to force sequential algorithms into parallel environments for such attempts usually result in transforming a good uniprocessor algorithm into a hopelessly greedy parallel algorithm. We show that by employing more local computation and mild redundance, a variety of problems can be solved in a resource- and time-efficient manner on a variety of architectures.
Micelle to extended multi-component bilayer systems involving decyl and dodecyl imidazolium and pyridinium cations (2013)

Imidazolium and pyridinium cations bearing C10 or C12n-alkyl chains form multi-component self-assembled bilayer arrangements in the solid state with p-sulfonated calix[4]arene and large tetra-aryl phosphonium cations, along with aquated Y3+ or Gd3+. The phosphonium cations are embedded in bilayers of calixarenes with the head group of the n-alkyl imidazolium or pyridinium cation directed into the cavity of the calixarene. The end of the alkyl chain penetrates the adjacent bilayer, with the flexibility of the alkyl moiety itself important in predetermining the arrangement of the components in the bilayers. Procrystal isosurface in the solid state has been investigated using CrystalExplorer, and the nature of the species in solution investigated using 1H NMR spectroscopy and dynamic light scattering, in understanding the link between spherical self-assembled species in solution and extended structures in the solid state.
EXTH-84. TARGETING THE SALVAGE PATHWAY OF NAD+ GENERATION IN GLIOMAS BY KPT-9274, A NOVEL DUAL INHIBITOR OF PAK4 AND NAMPT (2017)

Current treatment of glioblastoma (GBM) with surgery and chemoRT yields an average survival of ~1.5 years, highlighting the need for more effective therapies. We have previously reported that PAK4 is a key modulator of radioresistance in GBM. Additionally, pathways that regulate differential energy metabolism in gliomas and circumvent tumor heterogeneity have recently emerged as promising therapeutic targets. We hypothesized that inhibition of NAMPT, the rate-limiting enzyme of the NAD+ salvage pathway, a key pathway preferentially used in glioma energy metabolism, would be effective against GBM. We tested the efficacy of KPT9274, a potent first-in-class dual inhibitor of PAK4 and NAMPT, currently in human trials against solid tumors and lymphomas (NCT02702492), on NAD levels and cell viability in glioma cell lines and patient-derived glioma stem-like cells (GSC). We also examined enzyme-kinetics of various components of the NAD salvage pathway and effects of NADH rescue by nicotinamide, NMN and NAD. Lastly, we examined the biological relevance of NAMPT inhibition in glioma cells and GSC using a combination of cell adhesion, wound-healing, transwell-migration and microtubule formation assays. Treatment with KPT9274 resulted in potent depletion of NAD in glioma cells which was rescued by nicotinamide, NMN and NAD demonstrating its specificity against NAMPT. KPT-9274 treatment resulted in potent inhibition of cell adhesion, migration, cell invasion, endothelial tube formation and proliferation in glioma cells and GSC. In vivo studies in mouse bioluminescent intracranial glioma PDX model as well as PK studies are ongoing to confirm the pre-clinical significance of targeting NAMPT in gliomas and will be presented. Our study demonstrates a key role for NAMPT in NAD generation in gliomas as seen by the potent biological effects of KPT-9274 against these tumors and supports the potential for targeting the NAD salvage pathway as a novel therapeutic strategy for treatment of GBM.
An Ionic-Liquid-Imprinted Nanocomposite Adsorbent: Simulation, Kinetics and Thermodynamic Studies of Triclosan Endocrine Disturbing Water Contaminant Removal (2022)

The presence of triclosan in water is toxic to human beings, hazardous to the environment and creates side effects and problems because this is an endocrine-disturbing water pollutant. Therefore, there is a great need for the separation of this notorious water pollutant at an effective, economic and eco-friendly level. The interface sorption was achieved on synthesized ionic liquid-based nanocomposites. An N-methyl butyl imidazolium bromide ionic liquid copper oxide nanocomposite was prepared using green methods and characterized by using proper spectroscopic methods. The nanocomposite was used to remove triclosan in water with the best conditions of time 30 min, concentration 100 µg/L, pH 8.0, dose 1.0 g/L and temperature 25 °C, with 90.2 µg/g removal capacity. The results obeyed Langmuir, Temkin and D-Rs isotherms with a first-order kinetic and liquid-film-diffusion kinetic model. The positive entropy value was 0.47 kJ/mol K, while the negative value of enthalpy was -0.11 kJ/mol. The negative values of free energy were -53.18, -74.17 and -76.14 kJ/mol at 20, 25 and 30 °C. These values confirmed exothermic and spontaneous sorption of triclosan. The combined effects of 3D parameters were also discussed. The supramolecular model was developed by simulation and chemical studies and suggested electrovalent bonding between triclosan and N-methyl butyl imidazolium bromide ionic liquid. Finally, this method is assumed as valuable for the elimination of triclosan in water.
Effect of thermal fluctuations in topological p-wave superconductors (2012)

We study the effect of thermal fluctuations on the topological stability of chiral p-wave superconductors. We consider two models of superconductors: spinless and spinful with a focus on topological properties and Majorana zero-energy modes. We show that proliferation of vortex-antivortex pairs above the Kosterlitz-Thouless temperature T_KT drives the transition from a thermal Quantum Hall insulator to a thermal metal/insulator, and dramatically modifies the ground-state degeneracy splitting. Therefore, in order to utilize 2D chiral p-wave superconductors for topological quantum computing, the temperature should be much smaller than T_KT. Within the spinful chiral p-wave model, we also investigate the interplay between half-quantum vortices carrying Majorana zero-energy modes and full-quantum vortices having trivial topological charge, and discuss topological properties of half-quantum vortices in the background of proliferating full-quantum vortices.
Strukturierte Facharztweiterbildung mit „protected time“ für Forschung: ein neuer Karriereweg für junge Chirurgen (2016)

Einleitung: Die Vereinbarkeit von Forschung und klinischer Tätigkeit stellt vor allem in operativen Fächern eine große Herausforderung dar. Um qualitativ hochwertige klinische und experimentelle Forschung während der Facharztausbildung realisieren zu können ist eine Zusicherung von geschützter Forschungszeit für junge Chirurgen wünschenswert. Die Umsetzung ist in dem anspruchsvollen klinischen Alltag jedoch nur schwer möglich.
A novel nanofabrication technique for the array of nanogap electrodes (2005)

We demonstrate that nanogap between gold and poly-Si electrodes can be defined without using e-beam lithography. The technique showed that reproducible nanogap distance of around 10 nm on the six-inch wafer be easily obtained. Binding of 15 nm gold nanoparticles across the 10 nm electrodes leading to a drastic change of the electrical conductance has also been observed. The key fabrication process was utilized the spacer as sacrificial layer to define the distance of the nanogap between the electrodes. Structures of nanogap were formed in the crossing region of two electrodes after removal of the sacrificial material. The feature size of nanogap electrodes fabricated using this technology is mainly limited by the thickness of spacer. Further experiments have shown that a 10 nm gap can be successfully obtained. Then, deposition of gold nanoparticles on nanogap electrodes after functionalized the surface of electrodes with amino group was performed for investigation of electrical properties shows a measurement of the I-V characteristics of a typical device before and after gold colloidal interaction on the nanogap. As can be clearly identified, the interaction with colloids leads to a drastic change of the device conductivity. Under bias of 3 volts, the current changes from 2 pA to 30 nA after deposition of 15 nm gold nanoparticles.
Simultaneous PES Generation, Timing Recovery, and Multi-Track Read on Patterned Media: Concept and Performance (2010)

This paper presents new work on the performance of the method for simultaneously detecting the position and timing error in bit patterned media (BPM). The regular spatial arrangement of bits in BPM allows position information and timing information to be extracted from the data. Our method exploits interference between adjacent tracks by employing a read head wider than the track pitch. The method also provides the capability of reading data from two tracks at the same time. Here we employ a more realistic read head field and more realistic shapes of the bit islands in simulations than in prior work. We determine the sensitivity of the position detection, timing recovery, and bit error rate of the method to manufacturing variations in the locations and sizes of bits.
Functional Characterization of a Phf8 Processed Pseudogene in the Mouse Genome (2023)

Most pseudogenes are generated when an RNA transcript is reverse-transcribed and integrated into the genome at a new location. Pseudogenes are often considered as an imperfect and silent copy of a functional gene because of the accumulation of numerous mutations in their sequence. Here we report the presence of <i>Pfh8-ps</i>, a <i>Phf8</i> retrotransposed pseudogene in the mouse genome, which has no disruptions in its coding sequence. We show that this pseudogene is mainly transcribed in testis and can produce a PHF8-PS protein in vivo. As the PHF8-PS protein has a well-conserved JmjC domain, we characterized its enzymatic activity and show that PHF8-PS does not have the intrinsic capability to demethylate H3K9me2 in vitro compared to the parental PHF8 protein. Surprisingly, PHF8-PS does not localize in the nucleus like PHF8, but rather is mostly located at the cytoplasm. Finally, our proteomic analysis of PHF8-PS-associated proteins revealed that PHF8-PS interacts not only with mitochondrial proteins, but also with prefoldin subunits (PFDN proteins) that deliver unfolded proteins to the cytosolic chaperonin complex implicated in the folding of cytosolic proteins. Together, our findings highlighted PHF8-PS as a new pseudogene-derived protein with distinct molecular functions from PHF8.
Significance Level of Factors for Different Airflow Management Configurations of Data Centers (2005)

Data centers are among the highest energy consuming facilities and are projected to continue to increase in their power consumption for the foreseeable future. Due to the increase of computing power and the decrease in available floor space, maintaining the reliability of the electronic equipment in data centers is a big thermal challenge and, cannot be achieved solely by increasing the cooling capacity of the room. The overall thermal performance of data centers is highly dependent upon the thermal architecture of the facility. This paper presents numerical results of a parametric study, carried out for seven, fairly common, candidate configurations available for the air ducting design for data centers. Among the many factors associated with the data center thermal performance, three main factors at different levels have been selected to characterize their effect. The factors studied are ceiling height, tile flow rate and the location of the return vents. The numerical modeling is performed using a commercially available computational fluid dynamics (CFD) code based on the finite volume approach. This study also includes a summary of the statistical analysis carried out on the data obtained from the numerical parametric analysis, to determine the significance level of each of the individual factors and their interactions, on the thermal performance of the data center. The approach used here is to take an Analysis of Variance (ANOVA) approach, as a tool for determining the significance level of the different variables that affect the overall data center thermal performance. The tile flow rate is found to have significant effect on the thermal performance of all data center configurations studied.
A Review of Current Cross-linked Polyethylenes Used in Total Joint Arthroplasty (2005)

Major improvements have been made in new polyethylenes in regards to wear resistance and oxidation resistance. The background for and explanation of these improvements are presented in this study. The various manufacturing processes are described along with the possible features that the differences in manufacturing processes may have on wear, rate of particle generation, oxidation and mechanical properties. The role of some of the new polyethylenes in permitting the use of larger-diameter heads and the advantages of large-head diameters are discussed. Some of the advantages of metal-on-polyethylene versus hard-on-hard bearings also are described.
A Wide-Band Lumped Circuit Model of the Therminal and Internal Electromagnetic Response of Coaxially Insulated Windings Mounted on a Core (2003)

A Wide-Band Lumped Circuit Model of the Therminal and Internal Electromagnetic Response of Coaxially Insulated Windings Mounted on a Core
Self-Limiting Electrospray Deposition on Polymer Templates (2020)

Electrospray deposition (ESD) applies a high voltage to liquids flowing through narrow capillaries to produce monodisperse generations of droplets down to hundreds of nanometers in diameter, each carrying a small amount of the delivered solute. This deposition method has been combined with insulated stencil masks for fabricating micropatterns by spraying solutions containing nanoparticles, polymers, or biomaterials. To optimize the fabrication process for micro-coatings, a self-limiting electrospray deposition (SLED) method has recently been developed. Here, we combine SLED with a pre-existing patterned polymer film to study SLED’s fundamental behavior in a bilayer geometry. SLED has been observed when glassy insulating materials are sprayed onto conductive substrates, where a thickness-limited film forms as charge accumulates and repels the arrival of additional charged droplets. In this study, polystyrene (PS), Parylene C, and SU-8 thin films of varying thickness on silicon are utilized as insulated spraying substrates. Polyvinylpyrrolidone (PVP), a thermoplastic polymer is sprayed below its glass transition temperature (Tg) to investigate the SLED behavior on the pre-deposited insulating films. Furthermore, to examine the effects of in-plane confinement on the spray, a microhole array patterned onto the PS thin film by laser dewetting was sprayed with dyed PVP in the SLED mode. This was then extended to an unmasked electrode array showing that masked SLED and laser dewetting could be used to target microscale regions of conventionally patterned electronics.