gebhart/patrepeval huggingface dataset:
N-Linked Glycosylation of the Hemagglutinin Protein Influences Virulence and Antigenicity of the 1918 Pandemic and Seasonal H1N1 Influenza A Viruses (2013)

The hemagglutinin (HA) protein is a major virulence determinant for the 1918 pandemic influenza virus; however, it encodes no known virulence-associated determinants. In comparison to seasonal influenza viruses of lesser virulence, the 1918 H1N1 virus has fewer glycosylation sequons on the HA globular head region. Using site-directed mutagenesis, we found that a 1918 HA recombinant virus, of high virulence, could be significantly attenuated in mice by adding two additional glycosylation sites (asparagine [Asn] 71 and Asn 286) on the side of the HA head. The 1918 HA recombinant virus was further attenuated by introducing two additional glycosylation sites on the top of the HA head at Asn 142 and Asn 172. In a reciprocal experimental approach, deletion of HA glycosylation sites (Asn 142 and Asn 177, but not Asn 71 and Asn 104) from a seasonal influenza H1N1 virus, A/Solomon Islands/2006 (SI/06), led to increased virulence in mice. The addition of glycosylation sites to 1918 HA and removal of glycosylation sites from SI/06 HA imposed constraints on the theoretical structure surrounding the glycan receptor binding sites, which in turn led to distinct glycan receptor binding properties. The modification of glycosylation sites for the 1918 and SI/06 viruses also caused changes in viral antigenicity based on cross-reactive hemagglutinin inhibition antibody titers with antisera from mice infected with wild-type or glycan mutant viruses. These results demonstrate that glycosylation patterns of the 1918 and seasonal H1N1 viruses directly contribute to differences in virulence and are partially responsible for their distinct antigenicity.
Lateral charge migration suppression of 3D-NAND flash by vth nearing for near data computing (2017)

Vth Nearing is proposed to suppress the lateral charge migration and to improve the reliability of 3D TLC NAND flash. By modulating the write data so that V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> of adjacent cells become close, the data-retention errors decrease by 40%. The acceptable data-retention time increases by 2.8-times. The proposal is implemented in the SSD controller for the near data computing.
Bandwidth analysis of low-complexity decoupling networks for multiple coupled antennas (2014)

In MIMO communication systems where coupled antennas are driven by independent amplifiers, a decoupling network is often used to eliminate power reflection from the antennas. The realization of the decoupling network is not unique, and different realizations have major differences in complexity and bandwidth. Recent designs for low-complexity networks show that a minimum of N <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> + N impedances are generally needed to achieve decoupling for N antennas. This paper provides a perturbation analysis of the bandwidth, and shows that a decoupling network with N <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> +2N impedances can often achieve a much wider bandwidth than N <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> +N impedances. We illustrate using a three-antenna example.
Hydrophobic Properties of Biofilm‐Enriched Hybrid Mortar (2016)

A mortar hybrid material is presented in which biomineralization processes are stimulated by adding a biological component, i.e., bacterial biofilm, to standard mortar. A material is obtained that exhibits increased roughness on the microscale and the nanoscale. Accordingly, the hybrid mortar not only resists wetting but also suppresses the uptake of water by capillary forces.
Influences of indium fluctuation to the carrier transport, auger recombination, and efficiency droop (2013)

Our recent preliminary studies show that the nanoscale indium fluctuation in InGaN quantum well LED plays an important key role in carrier transport, radiative recombination, Auger, and droop effects. In this paper, we further examine the influence indium fluctuation for different degree of fluctuation, auger coefficients, and non-radiative lifetime. The influence of different AlGaN electronic blocking layer will be discussed in this paper. The commercial grade LED will be used for comparison to examine the model accuracy.
Genotype–Phenotype Relations in Primary Familial Brain Calcification: Systematic MDSGene Review (2021)

This systematic MDSGene review covers individuals with confirmed genetic forms of primary familial brain calcification (PFBC) available in the literature. Data on 516 (47% men) individuals, carrying heterozygous variants in SLC20A2 (solute carrier family 20 member 2, 61%), PDGFB (platelet-derived growth factor subunit B, 12%), XPR1 (xenotropic and polytropic retrovirus receptor, 16%), or PDGFRB (platelet-derived growth factor receptor beta, 5%) or biallelic variants in MYORG (myogenesis-regulating glycosidase, 13%) or JAM2 (junctional adhesion molecule 2, 2%), were extracted from 93 articles. Nearly one-third of the mutation carriers were clinically unaffected. Carriers of PDGFRB variants were more likely to be clinically unaffected (~54%), and the penetrance of SLC20A2 and XPR1 variants (<70%) was lower in comparison to the remaining three genes (>85%). Among the 349 clinically affected patients, 27% showed only motor and 31% only nonmotor symptoms/signs, whereas the remaining 42% had a combination thereof. While parkinsonism and speech disturbance were the most frequently reported motor manifestations, cognitive deficits, headache, and depression were the major nonmotor symptoms/signs. The basal ganglia were always calcified, and the cerebellum, thalamus, and white matter contained calcifications in 58%, 53%, and 43%, respectively, of individuals. In autosomal-dominant PFBC, mutation severity influenced the number of calcified brain areas, which in turn correlated with the clinical status, whereby the risk of developing symptoms/signs more than doubled for each additional region with calcifications. Our systematic analysis provides the most comprehensive insight into genetic, clinical, and neuroimaging features of known PFBC forms, to date. In addition, it puts forth the penetrance estimates and newly discovered genotype-phenotype relations that will improve counseling of individuals with mutations in PFBC genes. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Best Practices Manual: Monitoring for CO<sub>2</sub> Storage (2018)

This best practices manual (BPM) describes lessons learned and best practices for monitoring carbon dioxide (CO2) geologic storage (herein “storage”) projects derived from extensive Plains CO2 Reduction (PCOR) Partnership regional characterization and field demonstration experience acquired via activities conducted throughout the PCOR Partnership region. This BPM is intended to 1) provide guidance to project developers, regulators, and other stakeholders in evaluating and developing CO2 storage opportunities and 2) serve as a reference for CO2 storage technical specialists.
Longitudinal ComBat: A method for harmonizing longitudinal multi-scanner imaging data (2020)

While aggregation of neuroimaging datasets from multiple sites and scanners can yield increased statistical power, it also presents challenges due to systematic scanner effects. This unwanted technical variability can introduce noise and bias into estimation of biological variability of interest. We propose a method for harmonizing longitudinal multi-scanner imaging data based on ComBat, a method originally developed for genomics and later adapted to cross-sectional neuroimaging data. Using longitudinal cortical thickness measurements from 663 participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) study, we demonstrate the presence of additive and multiplicative scanner effects in various brain regions. We compare estimates of the association between diagnosis and change in cortical thickness over time using three versions of the ADNI data: unharmonized data, data harmonized using cross-sectional ComBat, and data harmonized using longitudinal ComBat. In simulation studies, we show that longitudinal ComBat is more powerful for detecting longitudinal change than cross-sectional ComBat and controls the type I error rate better than unharmonized data with scanner included as a covariate. The proposed method would be useful for other types of longitudinal data requiring harmonization, such as genomic data, or neuroimaging studies of neurodevelopment, psychiatric disorders, or other neurological diseases.
Metamaterial waveguides with low distributed backscattering in production O-band Si photonics (2017)

We report on the first measurement of distributed backscattering in metamaterial (subwavelength grating) waveguides. We find distributed backscattering to be &lt; -50 dB/mm in samples fabricated using a CMOS-integrated Si photonic production process.
Formation of chromium oxide on 316L austenitic stainless steel (1996)

The new technology using electrochemical buffed 316L austenitic stainless steel was developed to form an oxide scale as a passivation film which consists of an outer surface that is a perfect chromium oxide (Cr2O3) layer of several tens nanometers thickness, and an inner part that contains iron and nickel oxides. This technology first makes the stainless steel surface feature a very fine grain structure and introduces Cr to the stainless steel surface through grain-boundary diffusion. Then a weak oxidizing ambience or a strong reductive ambience is created to perform oxidation to form a perfect Cr2O3 film. Growth behavior of Cr2O3 film was analyzed with x-ray photoelectron spectroscopy by varying each parameter of moisture, concentration, temperature, and duration of thermal treatment in ambience. The corrosion resistance of this film showed an excellent characteristic compared with the conventional electropolished surface. This shows a possibility of its application to specialty gas handling in semiconductor device manufacturing.
Abstract 142 (2013)

AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK
Defining signatures of peripheral T-cell lymphoma with a targeted 20-marker gene expression profiling assay (2019)

Peripheral T-cell lymphoma comprises a heterogeneous group of mature non-Hodgkin lymphomas. Their diagnosis is challenging, with up to 30% of cases remaining unclassifiable and referred to as "not otherwise specified". We developed a reverse transcriptase-multiplex ligation-dependent probe amplification gene expression profiling assay to differentiate the main T-cell lymphoma entities and to study the heterogeneity of the "not specified" category. The test evaluates the expression of 20 genes, including 17 markers relevant to T-cell immunology and lymphoma biopathology, one Epstein-Barr virus-related transcript, and variants of <i>RHOA</i> (G17V) and <i>IDH2</i> (R172K/T). By unsupervised hierarchical clustering, our assay accurately identified 21 of 21 ALK-positive anaplastic large cell lymphomas, 16 of 16 extranodal natural killer (NK)/T-cell lymphomas, 6 of 6 hepatosplenic T-cell lymphomas, and 13 of 13 adult T-cell leukemia/lymphomas. ALK-negative anaplastic lymphomas (n=34) segregated into one cytotoxic cluster (n=10) and one non-cytotoxic cluster expressing Th2 markers (n=24) and enriched in <i>DUSP22</i>-rearranged cases. The 63 T<sub>FH</sub>-derived lymphomas divided into two subgroups according to a predominant T<sub>FH</sub> (n=50) or an enrichment in Th2 (n=13) signatures. We next developed a support vector machine predictor which attributed a molecular class to 27 of 77 not specified T-cell lymphomas: 17 T<sub>FH</sub>, five cytotoxic ALK-negative anaplastic and five NK/T-cell lymphomas. Among the remaining cases, we identified two cell-of-origin subgroups corresponding to cytotoxic/Th1 (n=19) and Th2 (n=24) signatures. A reproducibility test on 40 cases yielded a 90% concordance between three independent laboratories. This study demonstrates the applicability of a simple gene expression assay for the classification of peripheral T-cell lymphomas. Its applicability to routinely-fixed samples makes it an attractive adjunct in diagnostic practice.
Synergetic Control of a 3-Φ Buck-Boost Current DC-Link EV Charger Considering Wide Output Range and Irregular Mains Conditions (2020)

A wide output voltage range EV charger employing a three-phase (3-Φ) buck-type current source rectifier (CSR)-stage and a series-connected boost-type DC/DC-stage is introduced. The system employs a novel control structure, enabling robust operation even under heavily unbalanced 3-Φ mains conditions. It is verified how the proposed concept achieves PFC operation while regulating the output voltage in a wide range, which requires both buck and boost functionality. This includes a synergetically combined control of the 3-Φ CSR input stage and of the subsequent DC/DC output stage. In this context, a variable DC-link current control strategy referred to as 2/3-PWM is implemented, which allows to switch only two out of the three phases of the CSR-stage. Moreover, seamless transitions between the different operating modes and modulation schemes are demonstrated for different output voltage regions. Finally, the performance of the proposed synergetic control structure is comprehensively validated with closed-loop circuit simulations, focusing on buck-boost operation and on irregular 3-Φ mains conditions, including harmonics distortion, phase loss (phase open-circuit or phase zero-voltage faults), and voltage spikes.
Identification of potent siRNA targeting complement C5 and its robust activity in pre-clinical models of myasthenia gravis and collagen-induced arthritis (2023)

Complement component 5 (C5), an important molecule in the complement cascade, blockade by antibodies shows clinical efficacy in treating complement-mediated disorders. However, insufficient blockading induced by single-nucleotide polymorphisms in the C5 protein or frequent development of "breakthrough" intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab have been reported. Herein, we developed a lipid nanoparticle (LNP)-formulated siRNA targeting C5 that was efficiently delivered to the liver and silenced C5 expression. We identified a potent C5-siRNA with an <i>in vitro</i> IC<sub>50</sub> of 420 pM and <i>in vivo</i> ED<sub>50</sub> of 0.017 mg/kg following a single administration. Single or repeated administrations of the LNP-formulated C5-siRNA allowed robust and durable suppression of liver C5 expression in mice. Complement C5 silencing ameliorated C5b-dependent anti-acetylcholine receptor antibody-induced myasthenia gravis and C5a-dependent collagen-induced arthritis symptoms. Similarly, in nonhuman primates, a single administration of C5-siRNA/LNP-induced dose-dependent plasma C5 suppression and concomitantly inhibited serum complement activity; complement activity recovered to the pre-treatment levels at 65 days post administration, thus indicating that the complement activity can be controlled for a specific period. Our findings provide the foundation for further developing C5-siRNA delivered via LNPs as a potential therapeutic for complement-mediated diseases.
Nuclear magnetic resonance studies of87Rb+ transport in perfused rat kidney (1988)

Conference Article| August 01 1988 Nuclear magnetic resonance studies of87Rb+ transport in perfused rat kidney ZOLTAN H. ENDRE; ZOLTAN H. ENDRE 1Clinical Magnetic Resonance Facility, John Radcliffe Hospital, Headington, Oxford OX3 9DU, U.K. Search for other works by this author on: This Site PubMed Google Scholar JONATHAN L. ALUS; JONATHAN L. ALUS 1Clinical Magnetic Resonance Facility, John Radcliffe Hospital, Headington, Oxford OX3 9DU, U.K. Search for other works by this author on: This Site PubMed Google Scholar PETER J. RATCLIFFE; PETER J. RATCLIFFE 1Clinical Magnetic Resonance Facility, John Radcliffe Hospital, Headington, Oxford OX3 9DU, U.K. Search for other works by this author on: This Site PubMed Google Scholar JOHN G. G. LEDINGHAM; JOHN G. G. LEDINGHAM 1Clinical Magnetic Resonance Facility, John Radcliffe Hospital, Headington, Oxford OX3 9DU, U.K. Search for other works by this author on: This Site PubMed Google Scholar GEORGE K. RADDA GEORGE K. RADDA 1Clinical Magnetic Resonance Facility, John Radcliffe Hospital, Headington, Oxford OX3 9DU, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1988) 16 (4): 596–597. https://doi.org/10.1042/bst0160596 Article history Received: November 09 1987 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation ZOLTAN H. ENDRE, JONATHAN L. ALUS, PETER J. RATCLIFFE, JOHN G. G. LEDINGHAM, GEORGE K. RADDA; Nuclear magnetic resonance studies of87Rb+ transport in perfused rat kidney. Biochem Soc Trans 1 August 1988; 16 (4): 596–597. doi: https://doi.org/10.1042/bst0160596 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: KHB, Krebs—bicarbonate buffer, Rb-KHB, Rb-containing KHB This content is only available as a PDF. © 1988 Biochemical Society1988 Article PDF first page preview Close Modal You do not currently have access to this content.
Direct Methanol Fuel Cell Performance of Disulfonated Poly(arylene ether benzonitrile) Copolymers (2004)

This paper reports the performance of direct methanol fuel cells (DMFCs) using novel disulfonated poly(arylene ether benzonitrile) copolymers derived from hexafluoro-isopropylidene diphenol (6F), 2,6-dichlorobenzonitrile, and 3,3'-disulfonated -dichloro diphenyl sulfone (SDCDPS). The membrane electrode assembly (MEA) which employed the sulfonated copolymer with 35 mol % of disulfonated comonomer as the proton exchange membrane had approximately 2-fold lower methanol crossover and slightly higher (about 10%) cell resistance than the MEA using the perfluorosulfonic acid Nafion membrane, resulting in an approximately 50% improvement in selectivity, regardless of membrane thickness. Accordingly, this MEA outperformed the Nafion MEA control in a DMFC single-cell test. For example, 200 mA/cm2 was obtained (compared with 150 mA/cm2 for the Nafion MEA) at 0.5 V at a temperature of 80°C and ambient air pressure. Similar experiments performed with nonfluorine-containing biphenol-based sulfonated poly(arylene ether sulfone) copolymers (BPSH) indicated that the compatibility of the polymer electrolyte with the electrodes likely has a critical role in initial DMFC performance. © 2004 The Electrochemical Society. All rights reserved.
2-Arylindene Metallocenes:  Conformationally Dynamic Catalysts To Control the Structure and Properties of Polypropylenes (2002)

Polymerization of propylene with catalysts derived from unbridged 2-arylindene metallocenes leads to elastomeric, low-tacticity polypropylenes. The polymerization behavior of these conformationally dynamic catalyst systems is interpreted in terms of a multistate mechanism where the catalyst enchains the monomer from both stereoselective and nonstereoselective conformations during the lifetime of a single polymer chain. The structure and properties of the polypropylenes depend sensitively on the metallocene and the polymerization conditions (temperature, pressure, monomer concentration); samples of low to intermediate isotacticity ([mmmm] = 20-40%) are elastomeric, with low densities and broad melting ranges that extend to 150 degrees C. Samples of higher tacticity ([mmmm] = 40-70%) behave as softened thermoplastics.
Passivation of triple cation perovskites using guanidinium iodide in inverted solar cells for improved open-circuit voltage and stability (2021)

Inverted device architectures in perovskite research were promising for faster commercialization given the simple processing routes and choice of hole transport materials such as PEDOT:PSS.
Magnetism and Magnetoresistance in Fe/Cu Granular Films Produced by Sputter Deposition and Subsequent Annealing (1997)

Magnetic properties and magnetoresistance (MR) have been studied in homogeneous and granular Fe x Cu 100- x films produced by sputter (SP)-deposition and subsequent annealing. Concentration dependence of the MR ratio shows a maximum at x =20 in the as-SP-deposited films. On the other hand, it shows a monotonic change (no maximum) after annealed at 673 K for 30 min. Such an MR variation by annealing is ascribed to the magnetic transition of Fe clusters in Cu matrices. Mössbauer spectra and thermomagnetic curves observed at low temperatures indicate that the as-SP-deposited Fe x Cu 100- x alloy films are f.c.c. for x <35 being spin-glass, while those ones annealed at 673 K for 30 min are f.c.c. and b.c.c. mixture, being a spin-glass and ferromagnetic complex for x =11 and an antiferromagnetic and ferromagnetic one for x =20.
URETERAL STONES CLINICAL GUIDELINES PANEL SUMMARY REPORT ON THE MANAGEMENT OF URETERAL CALCULI (1997)

Most ureteral stones will pass spontaneously. Those that do not can be removed by either shock wave lithotripsy or ureteroscopy. Traditional blind basket extraction, without fluoroscopic control and guide wires, is not recommended. Open surgery is appropriate as a salvage procedure or in certain unusual circumstances.
Compensation Comparison Method for Assessment of Retinal Straylight (2006)

The compensation comparison method for measuring retinal straylight is suited for clinical use to diagnose patients with complaints caused by large angle light scattering in the eye such as early cataract.
Utilization of adaptive neuro-fuzzy interference system and functional network in prediction of total organic carbon content (2021)

Abstract This paper presents the application of two artificial intelligence (AI) approaches in the prediction of total organic carbon content (TOC) in Devonian Duvernay shale. To develop and test the models, around 1250 data points from three wells were used. Each point comprises TOC value with corresponding spectral and conventional well logs. The tested AI techniques are adaptive neuro-fuzzy interference system (ANFIS) and functional network (FN) which their predictions are compared to existing empirical correlations. Out of these two methods, ANFIS yielded the best outcomes with 0.98, 0.90, and 0.95 correlation coefficients (R) in training, testing, and validation respectively, and the average errors ranged between 7 and 18%. In contrast, the empirical correlations resulted in R values less than 0.85 and average errors greater than 20%. Out of eight inputs, gamma ray was found to have the most significant impact on TOC prediction. In comparison to the experimental procedures, AI-based models produces continuous TOC profiles with good prediction accuracy. The intelligent models are developed from preexisting data which saves time and costs. Article highlights In contrast to existing empirical correlation, the AI-based models yielded more accurate TOC predictions. Out of the two AI methods used in this article, ANFIS generated the best estimations in all datasets that have been tested. The reported outcomes show the reliability of the presented models to determine TOC for Devonian shale.