gebhart/patrepeval huggingface dataset:
Net Income Measurement, Investor Inattention, and Firm Decisions (2022)

When investors have limited attention, does the way in which net income is measured matter for firm value and firms' re source al location decisions? This pa per us es th e Ac counting Standards Update (ASU) 2016-01, which requires public firms to incorporate changes in unrealized gains and losses (UGL) on equity securities into net income, to answer this question. We build a model with risk-averse investors who can be attentive or inattentive and managers who choose how much to invest in financial assets to maximize firms' stock prices. The model predicts that, with inattentive investors, stock prices react more to changes in UGL from equity securities under the new regime and, under certain conditions, investors assign larger price discounts. Managers respond to such discounts by cutting financial asset holdings. We use insurance company data to test these predictions. Prices of stocks with low analyst coverage react more to changes in UGL from equity securities, highlighting the role of investor inattention. Using a difference-indifferences approach, we find that by 2020, publicly traded insurance companies cut investments in public stocks by $23 billion.
Lymphocyte adhesion mediated by integrins (1993)

In order to effectively defend the body against infectious organisms, cells of the immune system should be able to circulate as non-adherent cells in blood and lymph, and to migrate as adherent cells throughout the tissues. To arrive at sites of infection and to adhere to target cells bearing foreign antigen, cells need to cross endothelial and vessel walls. To control this rapid transition between adherent and non-adherent states, lymphocytes are equipped with different adhesion receptors. Integrins form a major group of adhesion receptors mediating the adhesion events of lymphocytes with antigen-bearing cells as well as between lymphocytes and endothelial cells (fig. 1). Lymphocytes express several integrin molecules at their cell surface which may all participate in the same intercellular interaction. Apart from integrins, lymphoid cells express other adhesion receptors which may regulate cell adhesion or contribute to the integrin-mediated cell-cell interaction. Cloning of the genes encoding these molecules and their counterreceptors revealed that they belong to distinct families of structurally related proteins : the selectins, immunoglobulin superfamily and the CD44 adhesion receptor (fig. 1). Here we focus on integrinmediated adhesion of lymphocytes; therefore, only integrins will be discussed in detail.
Chapter 1. Zeolite Science and Perspectives (2017)

This chapter provides an overview of the fascinating world of zeolites and related microporous solids. After a short historical background, the progress made during the modern era of the science and technology of zeolites is briefly introduced. All these topics are illustrated and discussed in detail in the other chapters of the book.
Ultra-narrow-linewidth erbium-doped lasers on a silicon photonics platform (2018)

We report ultra-narrow-linewidth erbium-doped aluminum oxide (Al<sub>2</sub>O<sub>3</sub>:Er<sup>3+</sup>) distributed feedback (DFB) lasers with a wavelength-insensitive silicon-compatible waveguide design. The waveguide consists of five silicon nitride (SiN<sub>x</sub>) segments buried under silicon dioxide (SiO<sub>2</sub>) with a layer Al<sub>2</sub>O<sub>3</sub>:Er<sup>3+</sup> deposited on top. This design has a high confinement factor (&gt; 85%) and a near perfect (&gt; 98%) intensity overlap for an octave-spanning range across near infrared wavelengths (950–2000 nm). We compare the performance of DFB lasers in discrete quarter phase shifted (QPS) cavity and distributed phase shifted (DPS) cavity. Using QPS-DFB configuration, we obtain maximum output powers of 0.41 mW, 0.76 mW, and 0.47 mW at widely spaced wavelengths within both the C and L bands of the erbium gain spectrum (1536 nm, 1566 nm, and 1596 nm). In a DPS cavity, we achieve an order of magnitude improvement in maximum output power (5.43 mW) and a side mode suppression ratio (SMSR) of &gt; 59.4 dB at an emission wavelength of 1565 nm. We observe an ultra-narrow linewidth of &Delta;&nu;DPS = 5.3 &plusmn; 0.3 kHz for the DPS-DFB laser, as compared to &Delta;&gamma;QPS = 30.4 &plusmn; 1.1 kHz for the QPS-DFB laser, measured by a recirculating self-heterodyne delayed interferometer (RSHDI). Even narrower linewidth can be achieved by mechanical stabilization of the setup, increasing the pump absorption efficiency, increasing the output power, or enhancing the cavity Q.
Les associations microbiennes dans le fromage de Roquefort. I. - Action des entérocoques vis-à-vis des streptocoques lactiques et des leuconostoc. Nature des substances stimulantes produites par Streptococcus faecalis var. liquefaciens (1970)

International audience
Process Evaluation of a Multidisciplinary Care Program for Patients Undergoing Gynaecological Surgery (2013)

The results of this study indicate good feasibility for implementation on a broad scale of the e-health intervention for patients undergoing benign gynaecological surgery. To enhance the implementation of the second step of the perioperative care program, adaptations in the integrated care protocol are needed.
PS1134 CHRONIC LYMPHOCYTIC LEUKEMIA CELLS IMPAIR MITOCHONDRIAL FITNESS IN T CELLS AND IMPEDE CAR T CELL EFFICACY (2019)

Background: Chronic lymphocytic leukemia (CLL) patients acquire T cell dysfunction through a yet unresolved mechanism, impeding efficacy of immunotherapeutic strategies. As T cell function and development share an intricate relationship with T cell metabolism, we hypothesized that CLL cells impose a reduction in mitochondrial fitness and altered glucose metabolism on T cells, which may underlie the acquired T cell dysfunction. Aims: We aim to elucidate the underlying mechanism of T cell dysfunction in CLL and intend to resolve metabolic dysfunction via pharmacological intervention. Methods: We selected untreated CLL patients with a WBC greater than 20 × 10 9 cells/L. Age‐matched healthy donors (HD) were used as controls. CAR T cells were obtained from the University of Pennsylvania, generated from relapsed/refractory (R/R) CLL patients enrolled in two clinical trials of single‐agent CTL019 therapy (registered at clinicaltrials.gov; NCT01029366, and NCT01747486). We either directly analyzed T cells by flow cytometry or XF96 Seahorse, or after a 2 day culture with or without CD3 and CD28 antibodies. Results: We have previously shown that stimulated CLL derived CD8 + T cells had reduced expression of activation markers, increased expression of PD‐1 and reduced expression of glucose transporter GLUT‐1, coinciding with reduced glucose uptake. In addition we observed that mitochondrial biogenesis is impaired in CLL derived CD8 + T cells. Clinical significance of this data was further demonstrated by analyzing mitochondrial mass of CAR T cells from CLL patients showing complete response (CR) versus patients with no response (NR). Patients with CR had higher mitochondrial mass compared to NR. These findings support our hypothesis that CLL cells reprogram T cell metabolism, in particular mitochondrial fitness and biogenesis (Blood 2018, 132:235). In this follow up study we investigated (A) whether metabolic reprogramming is a pan T cell phenomenon or CD8 specific, (B) upstream signaling leading to metabolic reprogramming, and (C) if pharmacological intervention can boost T cell metabolism and thereby function. We found that (A) CD4 T cells share most metabolic alterations with CD8 T cells in CLL, and that (B) AKT signaling is disturbed in CLL T cells. For the metabolic interventions studies (C) we are currently exploring the effects of manipulating mitochondrial ROS or respiration, and blocking immune‐suppressive cytokines. Results of both approaches will be presented at the conference. Summary/Conclusion: We found that metabolic impairment in CLL T cells is not restricted to CD8 T cells, but also applies to CD4 T cells, and that impaired AKT signaling is at least part of the upstream bottleneck. We are currently investigating the use of compounds and metabolites in order to improve mitochondrial fitness of T cells for CLL patients to benefit autologous immunotherapies.
MMICs for next generation radar (2017)

The rapid progress towards 5G wireless systems is accelerating the development of mm-wave semiconductor processes, broadband circuits, and system technologies. Similarly, next-generation radar is being expanded and redefined. Legacy radar systems are nearing the end of their life cycle and systems developers are aiming to upgrade their capability while reducing cost, size, and weight. Radar systems have requirements that result in technical circuit design challenges including high power, broadband, and low distortion. This paper focuses on MMIC design challenges specific to the design of next-generation radars that will operate in a crowded wireless environment, allow spectrum sharing, and dynamic frequency selection. Simulated and measured data are presented.
3-D mapping of permeable structures affecting a deep granite basement using isotropic 3C VSP data (2011)

International audience
Collective activation and activity propagation in engineered networks of neuronal clusters (2010)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Consumer Preferences for Fresh Citrus: Impacts of Demographic and Behavioral Characteristics (2011)

In the last twenty years, trends within fresh fruit consumption have shifted from consumption of fresh citrus to non-citrus fresh fruit. Within citrus, consumers are switching from the traditionally dominant fruit, oranges, to tangerines. Using survey results from three cities in the U.S. on consumer preferences for fresh citrus products, we demonstrate that freshness, flavor and appearance are the most important attributes of fresh citrus. Heterogeneous preferences exist among consumers and both demographic and behavioral variables have significant impacts on preferences. Results indicate there are no dominant best predictors of consumer preferences. However, it appears there is potential to develop specific marketing strategies based on demographics.
ChemInform Abstract: Synthesis of LiCoO2 by Decomposition and Intercalation of Hydroxides. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Modeling and analyzing power system failures on cloud services (2017)

Many enterprises rely on cloud infrastructure to host their critical applications (such as trading, banking transaction, airline reservation system, and credit card authorization). The unavailability of these applications may lead to severe consequences that go beyond the financial losses, reaching the cloud provider reputation too. However, to maintain high availability in a cloud data center is a difficult task due to its complexity. The power subsystem is crucial for the entire operation of the data center because it supplies power for all other subsystems, including IT components and cooling equipment. Some studies have already proposed models to evaluate the availability of the power subsystem, but none of them are based on standard redundancy models. Standards guide cloud providers regarding availability, points of failure, and watts per square foot based on components' redundancy. This paper proposes RBD and Petri Net models based on the TIA-942 standard to estimate the availability of the data center power subsystem and analyze how failures on power subsystem impact the availability of critical applications. These models are important to resource planning and decision making by the cloud providers, because they may identify which components they ought to invest in order to improve the availability level.
Some characteristics of extracellular proteases produced by members of the Chytridiales and the Spizellomycetales (Chytridiomycetes) (1994)

The extracellular proteolytic enzymes of eight saprophytic, eucarpic, and monocentric isolates from two genera of the order Spizellomycetales and from one genus of the order Chytridiales (Chytridiomycetes) have been partially characterized. The isolectric points of the proteases were estimated from zymograms and demonstrate the existence of three types of proteolytic activity in most isolates. The proteases were tested against synthetic chromogenic peptide substrates and a selection of cations and more complex compounds, and the results suggest that parts of the extracellular proteolytic activities are due to proteases from two groups: the Ca 2+ stabilized proteases and the alkaline serine proteases.Key words: serine proteases, metalloproteases, Chytridiomycetes, isoelectric focusing, chromogenic peptide substrates.
Evaluation of 4D CT acquisition methods designed to reduce artifacts (2015)

Four-dimensional computed tomography (4D CT) is used to account for respiratory motion in radiation treatment planning, but artifacts resulting from the acquisition and postprocessing limit its accuracy. We investigated the efficacy of three experimental 4D CT acquisition methods to reduce artifacts in a prospective institutional review board approved study. Eighteen thoracic patients scheduled to undergo radiation therapy received standard clinical 4D CT scans followed by each of the alternative 4D CT acquisitions: 1) data oversampling, 2) beam gating with breathing irregularities, and 3) rescanning the clinical acquisition acquired during irregular breathing. Relative values of a validated correlation-based artifact metric (CM) determined the best acquisition method per patient. Each 4D CT was processed by an extended phase sorting approach that optimizes the quantitative artifact metric (CM sorting). The clinical acquisitions were also postprocessed by phase sorting for artifact comparison of our current clinical implementation with the experimental methods. The oversampling acquisition achieved the lowest artifact presence among all acquisitions, achieving a 27% reduction from the current clinical 4D CT implementation (95% confidence interval = 34-20). The rescan method presented a significantly higher artifact presence from the clinical acquisition (37%; p &lt; 0.002), the gating acquisition (26%; p &lt; 0.005), and the oversampling acquisition (31%; p &lt; 0.001), while the data lacked evidence of a significant difference between the clinical, gating, and oversampling methods. The oversampling acquisition reduced artifact presence from the current clinical 4D CT implementation to the largest degree and provided the simplest and most reproducible implementation. The rescan acquisition increased artifact presence significantly, compared to all acquisitions, and suffered from combination of data from independent scans over which large internal anatomic shifts occurred.
Abstract 5446: Continuous real-time measurement of live and dead cells in culture over multiple days (2015)

Abstract Recently developed assay technologies have made it possible to use a multi-well plate reader to estimate the number of live or dead cells in culture in real time over a period of days to monitor the effects of long term exposure to test substances. An advantage of the real time assay chemistries is that the cells remain viable and available for other measurements. The purpose of this study was to determine if the real time assay methods could be multiplexed with other assay endpoints and applied to three dimensional (3D) culture models. The measurement of the number of live cells in real time is accomplished by providing a pro-substrate that viable cells (but not dead cells) can convert into a substrate for a luciferase derived from a marine shrimp. The pro-substrate and luciferase can be added with a single reagent addition step and because they are not toxic, they can be incubated with cells in culture for up to three days. Live cell conversion of the pro-substrate into a substrate for luciferase results in a luminescent signal that is proportional to the number of live cells. The signal diminishes immediately upon cell death. Detection of dead cells in real time is accomplished by using a fluorogenic DNA binding dye that is non-permeant and thus non-toxic to live cells. The dye enters dead cells that have a compromised membrane, binds to DNA, and becomes fluorescent. We have demonstrated that the real time assays can be multiplexed to measure both live and dead cells in the same sample. We further demonstrate the use of these assays to measure viability of cells in 3D spheroids formed using the hanging drop culture technique. We also demonstrate multiplexing of real time assays with subsequent measurement of apoptosis or extraction of RNA for expression studies. Utilization of real time assay chemistries that are non-toxic enabled repeated recording of data in a kinetic mode from the same sample of cells which eliminated the need for duplicate cultures and provided flexibility during assay protocol development. The ability to multiplex real time assays improved overall lab efficiency by eliminating the need for duplicate cultures for each experiment. Citation Format: Terry Riss, Jolanta Vidugiriene, Sarah Duellman, Wenhui Zhou, Gediminas Vidugiris, Mike Valley, Jean Osterman, Ruslan Arbit, Laurent Bernad, Poncho Meisenheimer, James J. Cali. Continuous real-time measurement of live and dead cells in culture over multiple days. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5446. doi:10.1158/1538-7445.AM2015-5446
Nonparametric Bayesian Models for Unsupervised Event Coreference Resolution (2009)

We present a sequence of unsupervised, nonparametric Bayesian models for clus-tering complex linguistic objects. In this approach, we consider a potentially infi-nite number of features and categorical outcomes. We evaluated these models for the task of within- and cross-document event coreference on two corpora. All the models we investigated show significant improvements when compared against an existing baseline for this task. 1
QoD Adaptation for Achieving Lifetime Predictability of WSN Nodes Communicating over Satellite Links (2007)

In this paper we propose an architecture consisting of a particular type of node, namely a communication server that collects and aggregates data, and establishes a link between the users and the sensor nodes through satellite communication. A key challenge with satisfying a lifetime requirement of the communication server is the unpredictability of the sensor data volume arriving at the communication server and the transmission power of the satellite terminal. To provide lifetime predictability we propose an approach that automatically adjusts the quality of the data such that the specified lifetime if achieved. We have shown through an extensive evaluation that the approach manages to provide an actual lifetime within 2% of the specified lifetime despite variations in workload and communication link quality.
Influence of Amide versus Ester Linkages on the Properties of Eight-Armed PEG-PLA Star Block Copolymer Hydrogels (2009)

Water-soluble eight-armed poly(ethylene glycol)-poly(l-lactide) star block copolymers linked by an amide or ester group between the PEG core and the PLA blocks (PEG-(NHCO)-(PLA)8 and PEG-(OCO)-(PLA)8) were synthesized by the stannous octoate catalyzed ring-opening polymerization of l-lactide using an amine- or hydroxyl-terminated eight-armed star PEG. At concentrations above the critical gel concentration, thermosensitive hydrogels were obtained, showing a reversible single gel-to-sol transition. At similar composition PEG-(NHCO)-(PLA)8 hydrogels were formed at significantly lower polymer concentrations and had higher storage moduli. Whereas the hydrolytic degradation/dissolution of the PEG-(OCO)-(PLA)8 takes place by preferential hydrolysis of the ester bond between the PEG and PLA block, the PEG-(NHCO)-(PLA)8 hydrogels degrade through hydrolysis of ester bonds in the PLA main chain. Because of their relatively good mechanical properties and slow degradation in vitro, PEG-(NHCO)-(PLA)8 hydrogels are interesting materials for biomedical applications such as controlled drug delivery systems and matrices for tissue engineering.
Radiance caching for efficient global illumination computation (2008)

In this paper we present a ray tracing based method for accelerated global illumination computation in scenes with low-frequency glossy BRDFs. The method is based on sparse sampling, caching, and interpolating radiance on glossy surfaces. In particular we extend the irradiance caching scheme of [WRC88] to cache and interpolate directional incoming radiance instead of irradiance. The incoming radiance at a point is represented by a vector of coefficients with respect to a spherical or hemispherical basis. The surfaces suitable for interpolation are selected automatically according to the glossiness of their BRDF. We also propose a novel method for computing translational radiance gradient at a point.
An Integrated System for Pipeline Condition Monitoring (2009)

ABSTRACT Pipelines are at risk from external threats including third-party intrusion, societal development and ground movement in addition to the ongoing potential for leaks due to corrosion or other causes. Although the appropriate use of internal inspection practices and regular survey of coating and cathodic protection systems will give timely information on any deterioration in pipeline condition, external threats can be unpredictable. In this paper we present the unique and innovative pipeline and flowline integrity monitoring system developed by Schlumberger in collaboration with BP. The system uses optical fiber distributed sensors to provide continuous, simultaneous distributed measurements of temperature, strain and vibration for the detection, monitoring, and location of events including:•Third-Party Interference (TPI), including multiple simultaneous disturbances•Geo-hazards for example landslides or subsidence•Gas and oil leaks•Permafrost protection Optical fiber sensors are widely used and have over the past 20+ years built a track record in the Oil &amp; Gas industry in applications including pipeline condition &amp; leak monitoring, optimization of oil well productivity and LNG plant leak detection and cool-down process monitoring. The solution provides a unique and proactive approach to pipeline integrity management. It performs analysis of a combination of measurands to provide the pipeline operator with an event recognition and location capability, in effect providing a hazard warning system, and offering the operator the potential to take early action to prevent loss. Through the use of remote, optically powered amplification, an unprecedented detection range of 100 km is possible without the need for any electronics and therefore remote power along the pipeline. A system can thus monitor 200 km of pipeline when configured to monitor 100 km upstream and downstream from a single location.