gebhart/patrepeval huggingface dataset:
Prevalence of Actinobacillus pleuropneumoniae, Actinobacillus suis, Haemophilus parasuis, Pasteurella multocida, and Streptococcus suis in representative Ontario swine herds. (2008)

Tonsillar and nasal swabs were collected from weanling pigs in 50 representative Ontario swine herds and tested for the presence of 5 important bacterial upper respiratory tract pathogens. All but 1 herd (2%) tested positive for Streptococcus suis by polymerase chain reaction (PCR); 48% of herds were S. suis serovar 2, 1/2 positive. In all but 2 herds there was evidence of Haemophilus parasuis infection. In contrast, toxigenic strains of Pasteurella multocida were detected by a P. multocida--enzyme-linked immunosorbant assay (PMT-ELISA) in only one herd. Seventy-eight percent of the herds were diagnosed positive for Actinobacillus pleuropneumoniae by apxIV PCR. Sera from finishing pigs on the same farms were also collected and tested by ELISA for the presence of A. pleuropneumoniae antibodies. Seventy percent of the herds tested had evidence of antibodies to A. pleuropneumoniae including serovars 1-9-11 (2%), 2 (4%), 3-6-8-15 (15%), 5 (6%), 4-7 (26%), and 12 (17%). This likely represents a shift from previous years when infection with A. pleuropneumoniae serovars 1, 5, and 7 predominated. At least 16% and possibly as many as 94% of the herds tested were Actinobacillus suis positive; only 3 of the 50 herds were both A. pleuropneumoniae and A. suis negative as judged by the absence of a positive PCR test for apxII. Taken together, these data suggest that over the past 10 years, there has been a shift in the presence of pathogenic bacteria carried by healthy Ontario swine with the virtual elimination of toxigenic strains of P. multocida and a move to less virulent A. pleuropneumoniae serovars. As well, there appears to be an increase in prevalence of S. suis serovar 2, 1/2, but this may be a reflection of the use of a more sensitive detection method.
Large angle SOI tilting actuator with integrated motion transformer and amplifier (2008)

In this work we report on the novel architecture and operational principle of a tilting actuator fabricated using a single structural layer of silicon on insulator (SOI) wafer and demonstrate the functionality of the device both theoretically and experimentally. The device incorporates an integrated compliant motion amplifier realized as an eccentric elastic torsion link that transforms small out-of-plane motion of the parallel plate electrostatic transducer into large amplitude angular motion of the tilting element. A feasibility study was performed using a lumped model of the device and verified by a coupled three-dimensional simulation. Experimental and model results indicate that this generic architecture, combining simple fabrication process with robustness of SOI based devices, is efficient for static and resonant operation of various tilting micro devices.
Total Synthesis of 3-<i>epi</i>-Juruenolide C (2019)

In this study, the total synthesis of 3-epi-juruenolide C is achieved in 10 steps (longest linear sequence) starting from ethyl (2E,4S,5S)-4,5-dihydroxy-2-hexenoate. The synthetic highlights of our approach include one-pot regioselective bromination, intramolecular carbonylation using bis(triphenylphosphine)dicarbonylnickel, and face-selective hydrogenation using a homogeneous Wilkinson's catalyst.
Fully CMOS compatible on-LSI capacitive pressure sensor fabricated using standard back-end-of-line processes (2005)

A surface micromachined capacitive pressure sensor was fabricated using conventional back-end of line (BEOL) processes in a standard CMOS fabrication line. The combination of standard interlayer dielectric and tungsten was used as sacrificial layers and electrodes, which achieves a large etching selectivity in sacrificial layer removal processes. Measured dependences of capacitance on applied pressure showed a good agreement with simulated results. Although the sensor used metal and amorphous layers in the moving parts (diaphragm), it showed excellent reliability. Sensor characteristics did not change after the deflection test for more than 50M times, temperature cycling test (-55 to 150 deg C, 500 cycles, JEDEC standard) and humidity test (85 deg C, 85% for 100 hr). The process enables us to monolithically integrate MEMS structures with the most advanced CMOS integrated circuits because they use only low temperature processes. Integrating MEMS with high performance digital circuits such as MPU as well as analog circuits enables ultra-tiny one-chip sensor devices.
Low Thermal Resistance, Low Current Density, High-Speed 980 and 850nm VCSELs (2006)

Copper plated, vertical cavity surface emitting lasers fabricated from AlGaAs structures, with thermal resistance up to 50% less than previously published values exhibit increased power, modulation current efficiency factor (MCEF), and maximum modulation bandwidth including 18 GHz at 8 kA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup>
Foliar surface free energy affects platinum nanoparticle adhesion, uptake, and translocation from leaves to roots in arugula and escarole (2017)

Low arugula surface free energy enhanced platinum nanoparticle adsorption, with decreased uptake and translocation to roots relative to escarole.
CFD Modeling of Fluidized Bed Reactor for the Synthesis of Dimethyl Ether (2011)

The syngas-to-DME reaction is highly exothermic, and the catalyst temperature window is very narrow. The fluidized-bed reactor is, therefore, an ideal choice to carry out these reactions. RTI is developing a circulating fluidized bed design for DME synthesis. This paper discusses a two-phase CFD model and optimization of the solids circulation rate.
RACH Optimization with Decision Tree Based Supervised Learning for Conditional Handover in 5G Beamformed Systems (2019)

Higher frequencies that are introduced in 5G networks cause rapid signal degradation and challenge user mobility. In recent studies, a conditional handover procedure has been adopted for 5G networks to enhance user mobility robustness. In this paper, mobility performance of the conditional handover is analysed for 5G mm-Wave systems with beamforming. In addition, a resource efficient random access procedure is proposed that increases the chance of contention-free random access during handover, which reduces signaling and interruption time. Moreover, simple, yet, effective decision tree based supervised learning method is proposed to minimize the handover failures that are caused by beam preparation phase of random access procedure. Results reveal the trade-off between contention free random access and handover failures. It is also shown that the optimum operation point of random access is achievable with proposed learning algorithm for conditional handover.
refund: Regression with Functional Data (2010)

Methods for regression for functional data, including function-on-scalar, scalar-on-function, and function-on-function regression.Some of the functions are applicable to image data.
Identification of wheat proteins involved in active stage of celiac disease: are gamma gliadins the major disease-specific antigens? (2011)

Methods We developed a method wherein the alcohol extracted gliadins was fractionated in two steps of ion-exchange chromatography, Sulphopropyl (SP) was used for the first step and the flow through (FT) fraction obtained was further fractionated using DEAE. Each generated fraction’s reactivity to serum IgA, from clinically well defined CD (active/diet) patients and non-CD patients was analyzed. Identification of disease specific antigens in the fractions was attempted using mass spectrometry and N-terminal sequencing.
A multifractal wavelet model with application to network traffic (1999)

We develop a new multiscale modeling framework for characterizing positive-valued data with long-range-dependent correlations (1/f noise). Using the Haar wavelet transform and a special multiplicative structure on the wavelet and scaling coefficients to ensure positive results, the model provides a rapid O(N) cascade algorithm for synthesizing N-point data sets. We study both the second-order and multifractal properties of the model, the latter after a tutorial overview of multifractal analysis. We derive a scheme for matching the model to real data observations and, to demonstrate its effectiveness, apply the model to network traffic synthesis. The flexibility and accuracy of the model and fitting procedure result in a close fit to the real data statistics (variance-time plots and moment scaling) and queuing behavior. Although for illustrative purposes we focus on applications in network traffic modeling, the multifractal wavelet model could be useful in a number of other areas involving positive data, including image processing, finance, and geophysics.
Erratum: The peripheral blood proteome signature of idiopathic pulmonary fibrosis is distinct from normal and is associated with novel immunological processes (2017)

Scientific Reports 7: Article number: 46560; published online: 25 April 2017; updated: 30 June 2017 The original version of this Article contained an error in the reference list, where reference 51 was incorrectly listed as “Ogawa, S. et al. Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder.
On-Chip Integration of Sequential Ion-Sensing System Based on Intermittent Reagent Pumping and Formation of Two-Layer Flow (2001)

A sequential ion-sensing system using a single microchip was successfully realized. The system developed here involves intermittent pumping of plural organic phases into a microchannel, followed by contact with a single aqueous phase to form a stable organic-aqueous two-layer flow inside the microchannel. Because the plural organic phases created by intermittent flow contain the same lipophilic pH indicator dye but different ion-selective neutral ionophores, different ions can be sequentially and selectively extracted into the different organic phases, where they can be determined by thermal lens microscopy (TLM). We used KD-A3 as the lipophilic pH indicator dye and valinomycin and DD16C5 as neutral ionophores to demonstrate sequential ion sensing of potassium and sodium ions by measuring the deprotonated dye caused by the ion extraction. The integrated microfluidic system proposed here allows multi-ion sensing, which is not easily demonstrated by conventional ion sensor technology using a solvent polymeric membrane. The minimum volume of single organic phase needed to obtain an equilibrium response without dilution by cross dispersion of two organic phases was ca. 500 nL in our system, indicating that the required amounts of expensive reagents in one measurement could be reduced to 1.7 ng and 2.8 ng for the dye and ionophore molecules, respectively.
ChemInform Abstract: Reactions of Diisopropyl Tartrate Modified Allyl‐ and (E)‐ and (Z)‐Crotylboronates with β‐Alkoxy‐α‐methylpropionaldehydes: A Reagent Based Solution to the Acyclic Dipropionate Problem. (1987)

Abstract Reactions of the chiral reagents (Ia) and (Ib) with the aldehydes (II) yield the compounds (III) ‐ (VI).
Training safer orthopedic surgeons (2015)

This study demonstrates the construct validity of a haptic VR trauma simulator with surgeons undertaking the procedure most frequently performing best on the simulator. VR simulation may be a means of addressing restrictions on working hours and allows trainees to practice technical tasks without putting patients at risk. The VR DHS simulator evaluated in this study may provide valid assessment of technical skill.
Every microsecond counts (2009)

Many network applications have stringent end-to-end latency requirements, including VoIP and interactive video conferencing, automated trading, and high-performance computing---where even microsecond variations may be intolerable. The resulting fine-grain measurement demands cannot be met effectively by existing technologies, such as SNMP, NetFlow, or active probing. We propose instrumenting routers with a hash-based primitive that we call a Lossy Difference Aggregator (LDA) to measure latencies down to tens of microseconds and losses as infrequent as one in a million.Such measurement can be viewed abstractly as what we refer to as a coordinated streaming problem, which is fundamentally harder than standard streaming problems due to the need to coordinate values between nodes. We describe a compact data structure that efficiently computes the average and standard deviation of latency and loss rate in a coordinated streaming environment. Our theoretical results translate to an efficient hardware implementation at 40 Gbps using less than 1% of a typical 65-nm 400-MHz networking ASIC. When compared to Poisson-spaced active probing with similar overheads, our LDA mechanism delivers orders of magnitude smaller relative error; active probing requires 50--60 times as much bandwidth to deliver similar levels of accuracy.
ChemInform Abstract: POTENTIAL ANTITUMOR AGENTS. 37. ORGANOPHOSPHORUS DERIVATIVES OF 9‐ANILINOACRIDINE (1983)

Abstract Das Chloracridin (I) reagiert mit den aromatischen Aminen (II) zu den 9‐Anilinoacridinen (III), die in vitro und in vivo auf Wirkung gegen L121 0‐ und P‐388‐Leukämie der Maus untersucht werden.
Impact of TiO2-II phase stabilized in anatase matrix by high-pressure torsion on electrocatalytic hydrogen production (2019)

Electrocatalysis using renewable energy sources provides a clean technology to produce hydrogen from water. Titanium oxide is considered as a potential electrocatalyst not only for hydrogen production but also for CO2 conversion. In this study, to enhance the cathodic electrocatalytic activity of TiO2, the phase composition on TiO2 surface is modified by inclusion of high-pressure TiO2-II phase using high-pressure torsion (HPT) straining. Detailed spectroscopic studies revealed that the energy band gap is reduced and the valence band energy increased with increasing the TiO2-II fraction. The highest electrocatalytic activity for hydrogen production was achieved on an anatase-rich nanocomposite containing TiO2-II nanograins.
Conserved missense variant in ALDH1A3 ortholog impairs fecundity in C. elegans (2021)

Accumulating evidence demonstrates that mutations in <i>ALDH1A3</i> (the aldehyde dehydrogenase 1 family, member A3) are associated with developmental defects. The ALDH1A3 enzyme catalyzes retinoic acid biosynthesis and is essential to patterning and neuronal differentiation in the development of embryonic nervous system. Several missense mutations in <i>ALDH1A3</i> have been identified in family studies of autosomal recessive microphthalmia, autism spectrum disorder, and other neurological disorders. However, there has been no evidence from animal models that verify the functional consequence of missense mutations in <i>ALDH1A3</i>. Here, we introduced the equivalent of the <i>ALDH1A3</i> C174Y variant into the <i>Caenorhabditis elegans</i> ortholog, <i>alh-1</i>, at the corresponding locus. Mutant animals with this missense mutation exhibited decreased fecundity by 50% compared to wild-type animals, indicating disrupted protein function. To our knowledge, this is the first ALDH1A3 C174Y missense model, which might be used to elucidate the effects of ALDH1A3 C174Y missense mutation in the retinoic acid signaling pathway during development.
Internet With Transient Destination-Controlled Addressing (2014)

Today's Internet makes hosts and individual networks inherently insecure because permanent addresses turn destinations into permanent attack targets. This paper describes an Evasive Internet Protocol (EIP), a change to the data plane of the Internet that: 1) prevents senders from forging their identities while preserving the current Internet privacy paradigm; 2) gives recipients full control over who can communicate with them and for how long; 3) achieves the above features without requiring global signaling protocols; and 4) allows coexistence with and graceful introduction into the current Internet. We motivate our approach, present the architectural design, and evaluate it through trace-driven and synthetic simulations as well as prototype testing.
An observational study of the AFGL infrared sky survey. IV - Further results from the revised catalog (1979)

Further efforts to confirm new 11 m sources reported in the AFOL Catalog have led to the verification of 16 sources and to the identification of the Cyg X complex of H ii regions in the catalog. Approximately 757o of the sources are now confirmed or identified with H ii regions. Our results suggest that eventually 807o of the AFOL 11 m sources will be confirmed. Subject headings: infrared: sources - nebulae: general - radio sources: extended
An On-Die All-Digital Power Supply Noise Analyzer With Enhanced Spectrum Measurements (2015)

A scalable all-digital power supply noise analyzer with 20 GHz sampling bandwidth and 1 mV resolution is demonstrated in 32 nm CMOS technology for enabling low-cost low-power in-situ power supply noise measurements without dedicated clean supplies and clock sources. This subsampled averaging-based analyzer measures power supply noise in both the equivalent-time and frequency domains with low-resolution VCO-based ADCs. For equivalent-time measurements, the accurate impedance characterization of power delivery networks is simply done by measuring a clock-synchronized current-step response. For frequency-domain measurements, the digital random phase-noise accumulation technique is analyzed and verified to overcome the clock-and-noise correlation issue in autocorrelation measurements. In general large scale integrated circuits and systems, the entire power supply noise analyzer consumes negligible active and leakage powers because of the MHz-range sampling clock frequency and fully digital implementation with only hundreds of logic gates.
Continuous-Flow Synthesis of Monoarylated Acetaldehydes Using Aryldiazonium Salts (2012)

Anilines and ethyl vinyl ether can be used as precursors for a process that is the synthetic equivalent of the α-arylation of acetaldehyde enolate. The reaction manifests a high level of functional group compatibility, allowing the ready preparation of a number of synthetically valuable compounds.
HYDRAULIC ACTUATOR FAULT DETECTION AND DIAGNOSIS: A ROBUST PARAMETRIC DECISION TEST (2016)

International audience
Supplementary Material for: Vitronectin Binds to a Specific Stretch within the Head Region of Yersinia Adhesin A and Thereby Modulates Yersinia enterocolitica Host Interaction (2016)

Complement resistance is an important virulence trait of <i>Yersinia enterocolitica (Ye)</i>. The predominant virulence factor expressed by <i>Ye</i> is <i>Yersinia</i> adhesin A (YadA), which enables bacterial attachment to host cells and extracellular matrix and additionally allows the acquisition of soluble serum factors. The serum glycoprotein vitronectin (Vn) acts as an inhibitory regulator of the terminal complement complex by inhibiting the lytic pore formation. Here, we show YadA-mediated direct interaction of <i>Ye</i> with Vn and investigated the role of this Vn binding during mouse infection in vivo. Using different <i>Yersinia</i> strains, we identified a short stretch in the YadA head domain of <i>Ye</i>O:9 E40, similar to the ‘uptake region' of <i>Y. pseudotuberculosis</i> YPIII YadA, as crucial for efficient Vn binding. Using recombinant fragments of Vn, we found the C-terminal part of Vn, including heparin-binding domain 3, to be responsible for binding to YadA. Moreover, we found that Vn bound to the bacterial surface is still functionally active and thus inhibits C5b-9 formation. In a mouse infection model, we demonstrate that Vn reduces complement-mediated killing of <i>Ye</i> O:9 E40 and, thus, improved bacterial survival. Taken together, these findings show that YadA-mediated Vn binding influences <i>Ye</i> pathogenesis.
Identification of novel microRNA biomarkers of viral infection (2010)

Background: It has become clear in the recent years that predictive biomarkers are becoming an integral part of successful clinical management. Further, a lack of clear biomarkers has created a real challenge in licensing biodefense therapeutics and vaccines. The study presented seeks to develop tools for the discovery of new microRNA (miRNA) biomarkers for infectious diseases using advanced computational tools coupled with high density microarrays and animal test facilities to find novel miRNA markers of viral infection. The system is expected to be of utility to diagnostics and vaccine and therapeutics development. Methods: Extant software developed for miRNA sequence mining coupled with supercomputers has been used to analyze the genomes of human, mouse, rhesus macaque, and all full-length viral genomes available to identify candidate miRNAs that may be of utility for detecting viral infections and other perturbances of normal metabolic function. These sequences are being incorporated into high density microarrays that will be used to assess miRNA expression responses from humans, rhesus macaques, and mice for any infectious agent. Initial tests will be conducted on healthy tissue and tissue infected with filoviruses to determine miRNA responses specific to filovirus infection. This system can also be used for any other viral infection as well as other metabolic disturbances not necessarily related to viral infection and for biomarker discovery related to therapeutics and vaccine efficacy testing. The research proposed also aims to apply, for the first time, an miRNA screening tool to discovery of miRNA biomarkers for filovirus infection. Results: We have thus far identified 20442 viral pre-miRNA sequences, and 124292, 90054, and 104037 pre-miRNA sequences for humans, macaque, and mouse, respectively. Conclusion: Given our preliminary results, we are confident that our experiments seeking to validate these predicted miRNAs will yield novel markers of infection. Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive
Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1. (1995)

BRCA1 is a breast/ovarian cancer susceptibility gene on human chromosome 17q21. We describe a complete and detailed physical map of a 500-kb region of genomic DNA containing the BRCA1 gene and the partial cloning in phage P1 artificial chromosomes. Approximately 70 exons were isolated from this region, 11 of which were components of the BRCA1 gene. Analysis of the other exons revealed a rho-related G protein and the interferon-induced leucine-zipper protein IFP-35.
Simplified carriage of MPEG immersive video in HEVC bitstream (2021)

Immersive video enables end users to experience video in a more natural way interactively with viewer motion from any position and orientation within a supported viewing space. MPEG Immersive Video (MIV) is an upcoming standard being developed to handle the compression and delivery of immersive media content. It extracts only needed information in the form of patches from a collection of cameras capturing the scene and compresses with video codecs such that the scene can be reconstructed at the decoder side from any pose. A MIV bitstream is composed of non-video components carrying view parameters and patch information in addition to multiple video data sub-bitstreams carrying texture and geometry information. In this paper, we describe a simplified MIV carriage method, using an SEI message within a single layer HEVC bitstream, to take advantage of existing video streaming infrastructure, including legacy video servers. The Freeport player is built on the open-source VLC video player, a GPU DirectX implementation of a MIV renderer, and a face tracking tool for viewer motion. A prerecorded demonstration of Freeport player is provided.