gebhart/patrepeval huggingface dataset:
Closed-Loop Drilling, Cementing, and Frequent Dynamic Formation Integrity Testing (2013)

Abstract " State of the art" is defined as the highest level of development, as of a particular device, technique or scientific field, achieved at a particular time. There are a number of examples in today's drilling industry that meet these criteria within their respective category. However, today's emphasis on well control, isolating potential flow zones during deepwater well construction &amp; abandonments and growing need to safely drill otherwise un-drillable prospects to increase recoverable reserves are unquestionably topics of great significance to the industry, regulatory community and public at large. This presentation speaks to ‘state of the art’ drilling technologies in respect to the circulating fluids systems used for drilling and isolating potential flow zones during well construction and plug &amp; abandonments (P&amp;A) on challenging deepwater drilling programs. Closed-Loop Drilling on deepwater rigs is enabled by a rotating control device (RCD) configured above or below the riser tension ring and a dedicated PLC automated choke system for mitigating drilling hazards such as narrow, shifting, or relatively unknown drilling margins, loss circulation, and kick-loss scenarios for the purposes of achieving deeper open hole sections with less non-productive time (NPT) and safely drilling otherwise un-drillable prospects. Dynamic Formation Integrity tests (FIT'S) are conducted much more frequently than industry norm (no need to stop drilling and exercise the BOP), perhaps after each stand is drilled in critical zones to spot weaker than predicted formations and to determine if the mud in the hole at the time is capable of preventing scenarios which may manifest excessive non-productive time and/or a well control incident of some significance. Closed-Loop Cementing enables actual (not predicted) data inputs to cementing simulator models, precise slurry displacement via annulus backpressure and ability to ascertain in real-time an induced fracture which may consume a quantity of the predetermined volume of cement required for effective zonal isolation and plug &amp; abandonments (P&amp;A). Deepwater drilling with closed circulating fluids systems (vs. conventional open-to-atmosphere annulus returns) and where mass flow in/out and other critical parameters of drilling and cementing hydraulics are precisely measured, controlled and documented in real time, enables safer &amp; more efficient decision-making on challenging deepwater drilling &amp; completions programs. Equally important, the methods described provide valuable documentation of compliance with API Standard 65, Part II - " Isolating Potential Flow Zones during Well Construction" with remote monitoring capability.
Free Radical Chemistry. 13 [1] Addition of Alkyl-Cyclohexanol Derivatives to HexafluoropropeneDedicated to Professor Dieter Naumann on the Occasion of his 60th Birthday (2002)

Free radicals derived from some alkyl substituted cyclohexanol derivatives react with hexafluoropropene to give a variety of polyfluoroalkylated adducts. Stereochemistry of the processes is discussed and remote functionalisation of the methyl group in 2-methylcyclohexanol by an unusual intramolecular hydrogen atom transfer process is reported. Chemie freier Radikale. 13. Addition von Alkylcyclohexanol-Derivaten an Hexafluoropropen Freie Radikale, die sich von einigen alkylsubstituierten Cyclohexanol-Derivaten ableiten, reagieren mit Hexa-fluoropropen unter Bildung einer Reihe von polyfluoroalkylierter Addukte. Die Stereochemie dieser Prozesse wird diskutiert und über die Funktionalisierung der Methylgruppe in 2-Methylcyclo-hexanol durch eine ungewöhnliche intramolekulare Wasserstoffatom-Übertragung wird berichtet.
Exploiting Natural Dynamics in the Control of a Planar Bipedal Walking Robot (1998)

Natural dynamics can be exploited in the control of bipedal walking robots: the swing leg can swing freely once started; a kneecap can be used to prevent the leg from inverting; and a compliant ankle can be used to naturally transfer the center of pressure along the foot and help in toe o#. Each of these mechanisms helps make control easier to achieve and results in motion that is smooth and natural looking. We describe a simple control algorithm using these natural mechanisms which requires very little computation. The necessary sensing consists of joint angles and velocities, body pitch and angular velocity, and ground reaction forces. Using this simple algorithm, we have controlled a seven link planar bipedal robot, called Spring Flamingo, to walk. Video, photographs, and more information on Spring Flamingo can be found at http://www.leglab.ai.mit.edu 1 Introduction A powerful practice in machine design and control is to design mechanisms which have natural dynamics that make contr...
Biomechanical Strain Induces Class A Scavenger Receptor Expression in Human Monocyte/Macrophages and THP-1 Cells (2001)

Biomechanical strain induces SRA expression by monocyte/macrophages, suggesting a novel mechanism for promotion of atherosclerosis in hypertensive patients.
Perturbation Theory–Machine Learning Study of Zeolite Materials Desilication (2018)

Zeolites are important materials for research and industrial applications. Mesopores are often introduced by desilication but other properties are also affected, making its optimization difficult. In this work, we demonstrate that Perturbation Theory and Machine Learning can be combined in a PTML multioutput model describing the effects of desilication. The PTML model achieves a notable accuracy ( R<sup>2</sup> = 0.98) in the external validation and can be useful for the rational design of novel materials.
Real-time fingerprint sensor using a hologram (1992)

A holographic fingerprint sensor has been developed for a system that identifies a person by his or her fingerprints. The sensor uses a laser as its light source and consists of a light-conducting plate, which is a transparent glass plate with a plain grating-type hologram, and a focusing lens system just under the hologram. Since the sensor uses a plane-parallel plate, all the optical paths from each point of a fingerprint to the hologram are equal, and a bright fingerprint can be created without the trapezoidal distortion that is inherent in conventional prism-type sensors.
Search for new particles decaying to ZZ using final states with leptons and jets with the ATLAS detector in s=7 TeV proton–proton collisions (2012)

Search for new particles decaying
Modified sperm stress test: a simple assay that predicts sperm-related abnormal in-vitro fertilization (1998)

Loss of sperm motility is associated with the process of sperm senescence and occurs at different rates within a given normal or abnormal sperm population. Reactive oxygen species attack cell membrane phospholipids, generating fatty acid peroxides and other degradation products, that also have deleterious effects on sperm motility and fertilizing ability. The objective of this investigation was to study a modification of the original sperm stress test (MOST), changing the culture medium to one offering transitional metals and shortening the total test time, to ascertain whether it can predict fertilization under these laboratory conditions. A total of 41 semen samples was obtained from patients undergoing in-vitro fertilization (IVF) at our institution. Semen samples were grouped into those producing total fertilization rates (FR) within normal limits (>50%) and those showing low total FR (<50%). The normal FR group had a significantly greater MOST mean value than the low FR group (0.71 versus 0.44). Furthermore, there was a statistically significant correlation between the MOST score and ungrouped fertilization rates (r = 0.53, P = 0.0004). Diagnostic statistics for MOST ratio values predicting <50% FR showed an optimal threshold of 0.39. Collectively, sensitivity, specificity, positive predictive value and negative predictive value have their largest values at this threshold. Taking into account the above mentioned threshold figures, there is a significant association between MOST and FR categories (P = 0.0009). In conclusion, MOST is a simple assay that has significant predictive value for sperm related IVF abnormalities.
Radio-frequency catheter ablation of atypical atrioventricular nodal reentrant tachycardia from a trans-aortic approach. (2009)

Radio-frequency catheter ablation (RFCA) was introduced for the treatment of reentrant tachyarrhythmias and has proven its usefulness, efficacy, and safety. It has gained the position of an early stage treatment option rather than being a 'last resort' option for certain groups of patients with supraventricular tachycardias including atrioventricular nodal reentrant tachycardia (AVNRT). The RFCA technique for AVNRT seems to have become established throughout these years and the right-side approach is considered to be the conventional method. However, in one percent of the patients with AVNRT it has been reported that they cannot be cured by the conventional method and a left-sided approach has been recommended. We experienced a case which presented with a fast/slow atypical AVNRT. We ultimately successfully treated the case with a left-sided (trans-aortic) RFCA approach. We believe the trans-aortic RFCA approach is a necessary alternative in the case of an unsuccessful RFCA via the right-sided approach even though the frequency of its need is very low.
Inferential framework for autonomous cryogenic loading operations (2017)

We address the problem of autonomous cryogenic management of loading operations on the ground and in space. As a step towards the solution of this problem we develop a probabilistic framework for inferring correlations parameters of two-fluid cryogenic flow. The simulation of two-phase cryogenic flow is performed using nearly-implicit scheme. A concise set of cryogenic correlations is introduced. The proposed approach is applied to an analysis of the cryogenic flow in experimental Propellant Loading System built at NASA Kennedy Space Center. An efficient simultaneous optimization of a large number of model parameters is demonstrated and a good agreement with the experimental data is obtained.
Serial data transmission at 224 Gbit/s applying directly modulated 850 and 910 nm VCSELs (2021)

Abstract High‐speed discrete multitone serial data transmission over multi‐mode fibre at gross data rates up to 224 Gbit/s achieved with directly modulated oxide‐confined vertical cavity surface emitting lasers at 850 and 910 nm are presented.
A mechanochemically synthesized covalent organic framework as a proton-conducting solid electrolyte (2016)

Mechanochemically synthesized bipyridine based covalent organic framework showing high proton conductivity of 0.014 S cm<sup>−1</sup> with improved performance over the solvothermal one giving a stable Open Circuit Voltage (0.93 V at 50 °C) on fabrication in PEM fuel cell.
Complex dynamics in unidirectionally coupled overdamped bistable systems subject to a time-periodic external signal (2005)

Recently, we have studied the emergence of oscillatory behavior in overdamped undriven nonlinear dynamic systems subject to carefully crafted coupling schemes and operating conditions [V. In, Phys. Rev. E 68, 045102(R) (2003).] The theoretical ideas have been validated in an experimental setup of N = 3 coupled ferromagnetic cores subject to a dc external magnetic "target" signal; the oscillations (corresponding to the periodic switching of each core between its stable steady states of magnetization) are triggered when the coupling constant crosses a threshold value, with the oscillation frequency exhibiting a characteristic scaling behavior with the "separation" of the coupling constant from its threshold value, as well as with the external signal amplitude. Here, we consider the system response to a time-periodic signal. We demonstrate experimentally that, depending on the signal amplitude and frequency, the response can be either synchronized to the signal frequency or to one-third this frequency. These phenomena afford unique techniques for time-periodic signal detection and characterization for a large class of sensors.
Significant Chondrocyte Viability Is Present in Acetabular Chondral Flaps Associated With Femoroacetabular Impingement (2017)

Full-thickness cartilage loss is a difficult problem for all active people but particularly in the young population in whom joint preservation is key. We describe the viability of chondrocytes present in full-thickness acetabular-based chondral flaps encountered during hip arthroscopy. Identification of greater than 85% chondrocyte viability supports a foundation for evaluation and creation of novel clinical innovations for repair and replacement techniques using the flap as donor tissue, as alternatives to chondroplasty and microfracture.
Removal of Trace Arsenic To Meet Drinking Water Standards Using Iron Oxide Coated Multiwall Carbon Nanotubes (2011)

This study presents the removal of trace level arsenic to meet drinking water standards using an iron oxide-multi-walled carbon nanotube (Fe-MWCNT) hybrid as a sorbent. The synthesis was facilitated by the high degree of nanotube functionalization using a microwave assisted process, and a controlled assembly of iron oxide was possible where the MWCNT served as an effective support for the oxide. In the final product, 11 % of the carbon atoms were attached to Fe. The Fe-MWCNT was effective in arsenic removal to below the drinking water standard levels of 10 µg L(-1). The absorption capacity of the composite was 1723 µg g(-1) and 189 µg g(-1) for As(III) and As(V) respectively. The adsorption of As(V) on Fe-MWCNT was faster than that of As(III). The pseudo-second order rate equation was found to effectively describe the kinetics of arsenic adsorption. The adsorption isotherms for As(III) and As(V) fitted both the Langmuir and Freundlich models.
Conversion of non-adipogenic fibroblasts into adipocytes by a defined hormone mixture (2015)

Obesity is accompanied by an increase in the size and the number of adipocytes. As adipocytes are thought to differentiate from pre-adipocytes, we postulate that non-adipogenic fibroblasts contribute to adipocyte formation under certain conditions such as obesity. We report for the first time that NIH-3T3 fibroblasts, which are generally considered to be non-adipogenic, can be converted into mature adipocytes by treatment with a defined hormone mixture comprising EGF (epidermal growth factor), HGF (hepatocyte growth factor), Dex (dexamethasone) and insulin. Furthermore, NIH-3T3 cells transplanted into obese immunodeficient NOD/SCID (non-obese diabetic/severe combined immunodeficient) mice formed adipocytes in vivo. Interestingly, the mixture elicited conversion of NIH-3T3 cells directly into adipocytes without a preceding pre-adipocyte stage. Functional analysis revealed that each component of the mixture was necessary for the induction of adipogenesis, including Dex which inhibited the cell proliferation stimulated by EGF. Upon profiling the signalling pathways employed by EGF and HGF, we found STAT5 (signal transducer and activator of transcription 5) signalling to be activated, predominantly at the levels of both transcription and post-translational modification. Inhibition of the STAT5 pathway, either by genetic knockdown or a specific pharmacological agent, blocked adipogenesis in NIH-3T3 cells. Taken together, these data not only establish a newly recognized grouping of factors that can induce trans-differentiation of non-adipogenic fibroblasts into adipocytes, but also give us a greater understanding of obesity.
LabVIEW based platform for prototyping dense LTE networks in CROWD project (2014)

Next generation wireless networks (5G) have to cope with significant traffic increase due to high quality video transmission and cloud-based applications. Such requirements create the need for a revolutionary change in architecture rather than a series of local and incremental technology updates. A dense heterogeneous deployment of small cells such as pico/femto cells in addition to high power macro cells is foreseen as one of the potential solutions to achieve these requirements. While there is significant amount of research in this area that relies on simulations at PHY, MAC and higher layers, it is still necessary to validate the algorithms for next generation systems in a real-time testbed. However, the ever increasing complexity in all layers of current and future generations of cellular wireless systems has made an end-to-end demonstration of the network limited to industrial research labs or large academic institutions. In this paper, we show a LabVIEW <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> based PXI platform in which LTE-like SISO OFDM PHY Layer is integrated with an open source protocol stack to prototype PHY/MAC cross layer algorithms within CROWD <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> Software Defined Networking (SDN) framework as a solution to tame dense deployment of wireless networks.
Probing the modulated formation of gold nanoparticles–beta-lactoglobulin corona complexes and their applications (2017)

Understanding the interactions between proteins and nanoparticles (NPs) along with the underlying structural and dynamic information is of utmost importance to exploit nanotechnology for biomedical applications. Upon adsorption onto a NP surface, proteins form a well-organized layer, termed the corona, that dictates the identity of the NP-protein complex and governs its biological pathways. Given its high biological relevance, in-depth molecular investigations and applications of NPs-protein corona complexes are still scarce, especially since different proteins form unique corona patterns, making identification of the biomolecular motifs at the interface critical. In this work, we provide molecular insights and structural characterizations of the bio-nano interface of a popular food-based protein, namely bovine beta-lactoglobulin (β-LG), with gold nanoparticles (AuNPs) and report on our investigations of the formation of corona complexes by combined molecular simulations and complementary experiments. Two major binding sites in β-LG were identified as being driven by citrate-mediated electrostatic interactions, while the associated binding kinetics and conformational changes in the secondary structures were also characterized. More importantly, the superior stability of the corona led us to further explore its biomedical applications, such as in the smartphone-based point-of-care biosensing of Escherichia coli (E. coli) and in the computed tomography (CT) of the gastrointestinal (GI) tract through oral administration to probe GI tolerance and functions. Considering their biocompatibility, edible nature, and efficient excretion through defecation, AuNPs-β-LG corona complexes have shown promising perspectives for future in vitro and in vivo clinical settings.
Class A Sodalites: Silver, Sodium, Halosodalites (1992)

Class A sodalites of the composition Na8X2(SiAlO4)6 were synthesized hydrothermally (X = Cl-, BR-, I-). AgNO3 melt and hydro aqueous exchanges were used to replace Na+ ions by Ag+ ions. The sodalite precursors and products were studied by chemical analysis, powder XRD, mid- and far-IR, multinuclear MAS and DOR NMR and optical reflectance spectroscopy. The structures of selected precursors as well as partially and fully silver exchanged sodalites were determined by Rietveld refinement of high resolution powder X-ray data The unit cell sizes on the and loading of cation and anion. Combined results from the above techniques indicated that a solid-solution structure Of cages with different cation contents was formed. Organized assemblies of Na4-nAgnX3+ clusters consisting of the components of insulators (NaX) and semiconductors (AgX) were encapsulated by the cubic sodalite framework which forms perfectly periodic arrays of all-space filling 6.6 A cages. The concentration and identity of cations and nature of the anion controlled the extent of vibrational and electronic coupling between clusters. Vibrational coupling was strongly mediated by the anions. Electronic interaction was possible through the framework (Na, Ag) or directly (Ag). Extended Huckel molecular orbital calculations supported the idea of band formation for an extended Na4-nAgnX3+ cluster lattice at increasing Ag+ loadings. They also aided in the assignment of the optical spectra. The calculations indicated that electronic transitions existed between clusters and the framework.
The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism (2013)

Adaptor proteins link surface receptors to intracellular signaling pathways and potentially control the way cells respond to nutrient availability. Mice deficient in p66Shc, the most recently evolved isoform of the Shc1 adaptor proteins and a mediator of receptor tyrosine kinase signaling, display resistance to diabetes and obesity. Using quantitative mass spectrometry, we found that p66Shc inhibited glucose metabolism. Depletion of p66Shc enhanced glycolysis and increased the allocation of glucose-derived carbon into anabolic metabolism, characteristics of a metabolic shift called the Warburg effect. This change in metabolism was mediated by the mammalian target of rapamycin (mTOR) because inhibition of mTOR with rapamycin reversed the glycolytic phenotype caused by p66Shc deficiency. Thus, unlike the other isoforms of Shc1, p66Shc appears to antagonize insulin and mTOR signaling, which limits glucose uptake and metabolism. Our results identify a critical inhibitory role for p66Shc in anabolic metabolism.
Association between combat-related traumatic injury and cardiovascular risk (2021)

CRTI is associated with an increased prevalence of MetS and arterial stiffness, which are also influenced by age, injury severity, physical activity and SEC. The longitudinal impact of CRTI on clinical cardiovascular events needs further examination.
ChemInform Abstract: Chemical Synthesis of Tin Oxide‐Based Materials for Li‐Ion Battery Anodes. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
TeOx thin films for an optical disc memory (1983)

Tellurium suboxide thin films TeOx were found to change in refractive index and extinction coefficient on thermal or optical heating, with accompanying changes in the reflectivity and transmission. The preparation method and thermal or optical properties of the TeOx thin films were investigated to obtain a stable and highly sensitive optical disc memory. A two-source evaporation method using Te and TeO2 provided uniform and any desired composition. The properties of the film depended on the x value; increasing x to as large as x=1.2, which represents a Te-poor composition, produced an excellent humidity and heat stability, and decreasing x to 0.8 made the film more sensitive to a laser diode, but susceptible to humidity. The TeO1.1 thin film was found to sufficiently satisfy all requirements for practical disc applications. A reflective optical disc was prepared using the TeO1.1 thin film deposited on a polymethylmethacrylate substrate with grooves for optical tracking. This disc is capable of recording video signals at real time by laser diodes. It showed no reflectivity changes on recorded or unrecorded areas and no sensitivity change to laser light after long term storage in high humidity and temperature.