gebhart/patrepeval huggingface dataset:
Bayesian link margins for opportunistic downlink packet systems (2008)

Downlink cellular packet systems utilizing opportunistic scheduling and adaptive modulation must deal with outdated channel state information. A fade margin is part of the link budget which is used to mitigate the effect of channel variation. Channel prediction reduces this margin, improving the transmission rate. We derive a fade margin which keeps packet outage constant for any prediction error variance. In our model both the signal and the interferer powers are modeled as autoregressive stochastic processes and predicted. The MMSE power predictor is also derived. Improvement in system throughput due to channel prediction is shown for a proportional fair scheduled downlink packet system, and compared to systems without prediction and opportunistic scheduling.
Absolute charge calibration of scintillating screens for relativistic electron detection (2010)

We report on new charge calibrations and linearity tests with high-dynamic range for eight different scintillating screens typically used for the detection of relativistic electrons from laser-plasma based acceleration schemes. The absolute charge calibration was done with picosecond electron bunches at the ELBE linear accelerator in Dresden. The lower detection limit in our setup for the most sensitive scintillating screen (KODAK Biomax MS) was 10 fC/mm(2). The screens showed a linear photon-to-charge dependency over several orders of magnitude. An onset of saturation effects starting around 10-100 pC/mm(2) was found for some of the screens. Additionally, a constant light source was employed as a luminosity reference to simplify the transfer of a one-time absolute calibration to different experimental setups.
Effect of polymer architecture on self‐diffusion of LC polymers (1999)

Two LC side-group poly(methacrylates) were synthesized, and their melt dynamics were compared with each other and a third, main-chain side-group combined LC polymer. A new route was developed for the synthesis of the poly(methacrylate) polymers which readily converts relatively inexpensive perdeuteromethyl methacrylate to other methacrylate monomers. Self-diffusion data was obtained through the use of forward recoil spectrometry, while modulus and viscosity data were measured using rotational rheometers in oscillatory shear. Diffusion coefficients and complex viscosity were compared to previous experiments on liquid crystal polymers of similar architecture to determine the effect of side-group interdigitation and chain packing on center of mass movement. The decyl terminated LC side-group polymer possessed an interdigitated smectic phase and a sharp discontinuity in the self-diffusion behavior at the clearing transition. In contrast, the self-diffusion behavior of the methyl terminated LC side-group polymer, which possessed head-to-head side-group packing, was seemingly unaffected by the smectic–nematic and nematic–isotropic phase transitions. The self-diffusion coefficients of both polymers were relatively insensitive to the apparent glass transition. The presence of moderately fast sub-Tg chain motion was supported by rheological measurements that provided further evidence of considerable molecular motion below Tg. The complex phase behavior of the combined main-chain side-group polymer heavily influenced both the self-diffusion and rheological behavior. Differences between the self-diffusion and viscosity data of the main-chain side-group polymer could be interpreted in terms of the defect structure. © 1999 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 37: 405–414, 1999
Supplementary Figure 1 from Characteristics of Lung Cancers Harboring <i>NRAS</i> Mutations (2023)

&lt;p&gt;PDF file - 66K, Figure S1. The distribution of known driver mutations in lung cancer patients at VICC. 451 lung cancer patients were analyzed using SnaPShot.(47) Patients with ALK fusions are not shown, as they were identified using a separate cytogenetic assay (fluorescent in situ hybridization).&lt;/p&gt;
Reactive Extrusion of Polypropylene and Nylon Blends from Commingled Plastic Wastes (2007)

Abstract Reactive extrusion for recycled PP/nylon blends from commingled plastic wastes was investigated through thermal, morphological, mechanical and rheological studies. From SEM investigation, we found improved surface morphologies with homogeneous domains in the recycled 75/25 PP/nylon blends compatibilized with copolymers containing maleic anhydride (MA) as a reactive functional group; SEBS‐g‐MA, PP‐g‐MA, PE‐g‐MA. Especially, SEBS‐g‐MA thermoplastic elastomer which is highly reactive with amine terminal group of nylon, resulted in a large increase of impact strength above nearly 200%. This compatibilization effect resulted from the increase of interfacial adhesion and the reduction of domain size of dispersed phase in PP/nylon blend system. To confirm the existence of this network structure, we measured a dynamic rheological properties.
Silicon-photonic network architectures for scalable, power-efficient multi-chip systems (2010)

Scaling trends of logic, memories, and interconnect networks lead towards dense many-core chips. Unfortunately, process yields and reticle sizes limit the scalability of large single-chip systems. Multi-chip systems break free of these areal limits, but in turn require enormous chip-to-chip bandwidth. The "macrochip" concept presented here integrates multiple many-core processor chips in a single package with silicon-photonic interconnects. This design enables a multi-chip system to approach the performance of a single large die.
High-Performance and Multifunctional Cement-Based Composite Material (2019)

Concrete is a continuously evolving material, and even the definition of high-performance concrete has changed over time. In this paper, high-performance characteristics of concrete material are considered to be those that support the desirable durability, resilience, and sustainability of civil infrastructure that directly impact our quality of life. It is proposed that high-performance material characteristics include tensile ductility, autogenous crack-width control, and material “greenness.” Furthermore, smart functionalities should be aimed at enhancing infrastructure durability, resilience, and sustainability by responding to changes in the surrounding environment of the structure in order to perform desirable functions, thus causing the material to behave in a manner more akin to certain biological materials. Based on recent advances in engineered cementitious composites (ECCs), this paper suggests that concrete embodying such high-performance characteristics and smart multifunctionalities can be designed, and holds the potential to fulfill the expected civil infrastructure needs of the 21st century. Highlights of relevant properties of ECCs are provided, and directions for necessary future research are indicated. Keywords: High-performance concrete, Multifunction, Smart, Cement-based composite, Durability, Resilience, Sustainability, Infrastructure
Augmenting Sheet Music with Rhythmic Fingerprints (2020)

In this paper, we bridge the gap between visualization and musicology by focusing on rhythm analysis tasks, which are tedious due to the complex visual encoding of the well-established Common Music Notation (CMN). Instead of replacing the CMN, we augment sheet music with rhythmic fingerprints to mitigate the complexity originating from the simultaneous encoding of musical features. The proposed visual design exploits music theory concepts such as the rhythm tree to facilitate the understanding of rhythmic information. Juxtaposing sheet music and the rhythmic fingerprints maintains the connection to the familiar representation. To investigate the usefulness of the rhythmic fingerprint design for identifying and comparing rhythmic patterns, we conducted a controlled user study with four experts and four novices. The results show that the rhythmic fingerprints enable novice users to recognize rhythmic patterns that only experts can identify using non-augmented sheet music.
Phenotypic Characterization of Youth Admitted To Acute Psychiatric Inpatient Unit Following Self-Harm Behavior (2021)

Findings suggest that early detection and intervention of DSH and depressive crisis is warranted, regardless of the self-harm subtype.HIGHLIGHTSDeliberate self-harm is common among adolescent psychiatric inpatients.Adolescent inpatients with deliberate self-harm are predominantly females with concurrent depression and suicidal ideation.We did not detect significant clinical and demographic differences between self-harmers with or without suicidal intent.
GeSn Alloys on Si Using Deuterated Stananne and Higher-Order Germanes: Synthesis and Properties (2012)

Abstract not Available.
Preload Sensitivity of the Jarvik 2000 and HeartMate II Left Ventricular Assist Devices (2008)

The in vitro sensitivity of continuous flow pumps to preload and afterload pressure has been well characterized. We compared flow in the Jarvik 2000 and HeartMate II continuous flow left ventricular assist devices (LVADs) at different inflow and outflow pressures and different pump speeds. This allowed us to measure the impact of a changing inflow pressure on the pump flow rate at different speeds but against a constant afterload. The resulting preload sensitivity curves showed that, overall, both LVADs have a mean preload sensitivity of 0.07 L/min/mm Hg in the physiologic ranges of pressures and flows encountered during normal operation. The HeartMate II pump had an increased preload sensitivity (up to approximately 0.1 L/min/mm Hg) as the preload was increased. The preload sensitivity of the Jarvik 2000 LVAD was more variable, having several peaks and troughs as the preload was increased. In future LVADs, improved preload sensitivity may allow passive regulation of pump output, optimize ventricular unloading, and decrease the risk of ventricular suction by the pump.
Linfuranones B and C, Furanone-Containing Polyketides from a Plant-Associated Sphaerimonospora mesophila (2018)

Two new furanone-containing polyketides, linfuranones B and C, were isolated from a plant-associated actinomycete of the genus Sphaerimonospora. Their structures were determined by NMR and MS spectroscopic analyses, and the absolute configurations were established by anisotropic methods and chemical degradation approaches. In silico analysis of biosynthetic genes suggested that linfuranone B is generated from linfuranone C by oxidative cleavage of the polyketide chain. Linfuranones B and C induced preadipocyte differentiation into matured adipocytes at 20-40 μM without showing cytotoxicity.
A High Resolution Method for On Line Diagnosis of Induction Motors Faults (2007)

The wide use of the induction motors for industrial and transport applications leads to increase the interest in their monitoring for on-line detection of incipient faults. The traditional diagnostic techniques are based on the stator current or torque spectral analysis by FFT-based methods. However, the well known spectral leakage phenomena of FFT can cause not accurate estimation of the spectral components; moreover, its frequency resolution problems limits a fast detection of the fault condition. In order to solve these problems, this paper presents an high resolution method, the ESPRIT method, to make the fault identification faster and accurate. A proper dynamic model of the induction machine is used to simulate the occurring of a fault condition. Simulation results allow to compare the ESPRIT and FFT-based methods, considering the case of some rotor bars broken.
Efficient and Robust Distributed Matrix Computations via Convolutional\n Coding (2019)

Distributed matrix computations -- matrix-matrix or matrix-vector\nmultiplications -- are well-recognized to suffer from the problem of stragglers\n(slow or failed worker nodes). Much of prior work in this area is (i) either\nsub-optimal in terms of its straggler resilience, or (ii) suffers from\nnumerical problems, i.e., there is a blow-up of round-off errors in the decoded\nresult owing to the high condition numbers of the corresponding decoding\nmatrices. Our work presents convolutional coding approach to this problem that\nremoves these limitations. It is optimal in terms of its straggler resilience,\nand has excellent numerical robustness as long as the workers' storage capacity\nis slightly higher than the fundamental lower bound. Moreover, it can be\ndecoded using a fast peeling decoder that only involves add/subtract\noperations. Our second approach has marginally higher decoding complexity than\nthe first one, but allows us to operate arbitrarily close to the lower bound.\nIts numerical robustness can be theoretically quantified by deriving a\ncomputable upper bound on the worst case condition number over all possible\ndecoding matrices by drawing connections with the properties of large Toeplitz\nmatrices. All above claims are backed up by extensive experiments done on the\nAWS cloud platform.\n
Abstract C42: QBI-139, a human RNase variant in a phase I trial, has broad in vivo efficacy (2009)

Abstract The RNA in cancer cells is the target of a new class of anti-cancer drugs: the EVade™ Ribonucleases (RNases). The EVade™ RNases are variants of native RNases that have been modified to diminish their binding to their natural inhibitor, allowing the EVade™ RNases to kill cancer cells. These RNase variants are broadly efficacious, competitive with approved drugs. A lead candidate, called QBI-139, has been selected for clinical devleopment and is currently in a Phase I clinical trial in patients with solid tumors. The next stage of development requires selection of a specific indication for a Phase II trial of QBI-139. In addition to the Phase I trial, mouse models of cancer will be used to select the tumor type for future development. The efficacy of QBI-139 in in vivo models of human cancer (e.g. lung, colon and prostate) has been examined relative to FDA approved cancer therapies. QBI-139 was tested at different doses in nude mouse xenograft models using a variety of tumor types and multiple cell lines within the different tumor types (e.g. prostate cancer cell lines DU145 and PC3). Each model compared the efficacy of QBI-139 with control groups which included: vehicle, and an effective commercial chemotherapeutic specific for each tumor type (e.g. docetaxel, 5-fluorouracil and cisplatin). The human cancer cells were grown in culture and approximately 5 ×106 cells were implanted subcutaneously into the flanks of (nu/nu) nude mice. The tumors are allowed to grow to ∼75 mm3 prior to treatment and all drugs were administered intraperitoneally (ip) once weekly. Calculated tumor volumes in mm3 and animal body weights (g) were recorded twice weekly. The percent tumor growth inhibition (TGI) used as a measure of efficacy was determined by comparing final and starting tumor volumes of groups treated with drug relative to the vehicle. A favorable response was seen for QBI-139 against prostate cancer (DU145) compared to docetaxel. The TGI of QBI-139 was 83% compared to 84% for docetaxel. Treatment with QBI-139 did not lead to observable toxicity and the mice all gained body during the course of treatment. In contrast, docetaxel treatment resulted in death for one mouse after 4 treatments (day 42) and another after 6 treatments (day 52). In colon cancer (HT-29), the efficacy of QBI-139 was 58%, similar to the results for 5-fluorouracil (54%). Additional results will be provided, including for multiple cell lines of human non-small cell lung cancer. QBI-139 is a broadly efficacious agent that provides a new way to attack the RNA in cancer cells and an innovative new tool for oncologists. The results above will be considered with the results of the Phase I trial to select an indication for a Phase II clinical trial. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):C42.
Mechanism of Action in Model Organisms: Interfacing Chemistry, Genetics and Genomics (2003)

This chapter contains sections titled: Introduction Introduction to Compound Development Model Organisms Arrive on the Scene Elucidating the Mechanism of Compound Action A Case Study for Alzheimer's Disease Drug Discovery New Chemical Genetic Strategies: Genome-wide Cell-based Genetic Screens A Case Study for Innate Immunity and Inflammation Drug Discovery Global Gene Expression Studies in MOA Selecting and Advancing Compound Leads Using Model Systems Future Perspectives Acknowledgments References
Platelet-derived lysophosphatidic acid decreases endothelial permeability in vitro (1998)

We previously reported that platelets release a soluble factor that decreases the solute permeability of cultured bovine aortic endothelial monolayers. This factor was characterized as heat stable, tryspsin sensitive, and not serotonin, adenosine, ADP, or ATP [F. R. Haselton and J. S. Alexander. Am. J. Physiol. 263 (Lung Cell Mol. Physiol. 7): L670-L678, 1992]. We now report its identity as lysophosphatidic acid (LPA). Endothelial permeability decreases rapidly, reversibly, and repeatedly when exposed to platelet supernatants. Continuous exposure produces a sustained decrease in permeability. Methanol extracts of platelet supernatants also decrease endothelial permeability. Treatment of methanol extracts of platelet supernatants with phospholipase B or alkaline phosphatase, which modify the structure of LPA, abolishes the permeability-decreasing activity. However, activity is unaffected by treatment with phospholipase A2. This pattern of enzyme inactivation is consistent with the structure of LPA. Furthermore, synthetic 1-oleoyl-LPA rapidly and significantly decreases endothelial permeability in a concentration-dependent manner. Platelet activation does not appear to be required to produce activity in supernatants from platelet isolations, since P-selectin expression is not increased and thromboxane B2 is < 14 pg/6,000 platelets. Our data show that platelets release a methanol-extractable compound with an enzyme degradation profile consistent with LPA, which decreases the permeability of endothelial monolayers in vitro. In vivo, LPA derived from platelets may be an important mediator of the transport barrier formed by the vascular endothelium.
Data from A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent (2023)

&lt;div&gt;Abstract&lt;p&gt;The stress-induced HSP70 is an ATP-dependent molecular chaperone that plays a key role in refolding misfolded proteins and promoting cell survival following stress. HSP70 is marginally expressed in nontransformed cells, but is greatly overexpressed in tumor cells. Silencing HSP70 is uniformly cytotoxic to tumor but not normal cells; therefore, there has been great interest in the development of HSP70 inhibitors for cancer therapy. Here, we report that the HSP70 inhibitor 2-phenylethynesulfonamide (PES) binds to the substrate-binding domain of HSP70 and requires the C-terminal helical “lid” of this protein (amino acids 573–616) to bind. Using molecular modeling and &lt;i&gt;in silico&lt;/i&gt; docking, we have identified a candidate binding site for PES in this region of HSP70, and we identify point mutants that fail to interact with PES. A preliminary structure–activity relationship analysis has revealed a derivative of PES, 2-(3-chlorophenyl) ethynesulfonamide (PES-Cl), which shows increased cytotoxicity and ability to inhibit autophagy, along with significantly improved ability to extend the life of mice with pre-B-cell lymphoma, compared with the parent compound (&lt;i&gt;P&lt;/i&gt; = 0.015). Interestingly, we also show that these HSP70 inhibitors impair the activity of the anaphase promoting complex/cyclosome (APC/C) in cell-free extracts, and induce G&lt;sub&gt;2&lt;/sub&gt;–M arrest and genomic instability in cancer cells. PES-Cl is thus a promising new anticancer compound with several notable mechanisms of action. &lt;i&gt;Mol Cancer Res; 11(3); 219–29. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Different evolutionary trajectories of vaccine-controlled and non-controlled avian infectious bronchitis viruses in commercial poultry (2017)

To determine the genetic and epidemiological relationship of infectious bronchitis virus (IBV) isolates from commercial poultry to attenuated live IBV vaccines we conducted a phylogenetic network analysis on the full-length S1 sequence for Arkansas (Ark), Massachusetts (Mass) and Delmarva/1639 (DMV/1639) type viruses isolated in 2015 from clinical cases by 3 different diagnostic laboratories. Phylogenetic network analysis of Ark isolates showed two predominant groups linked by 2 mutations, consistent with subpopulations found in commercial vaccines for this IBV type. In addition, a number of satellite groups surrounding the two predominant populations were observed for the Ark type virus, which is likely due to mutations associated with the nature of this vaccine to persist in flocks. The phylogenetic network analysis of Mass-type viruses shows two groupings corresponding to different manufacturers vaccine sequences. No satellite groups were observed for Mass-type viruses, which is consistent with no persistence of this vaccine type in the field. At the time of collection, no vaccine was being used for the DMV/1639 type viruses and phylogenetic network analysis showed a dispersed network suggesting no clear change in genetic distribution. Selection pressure analysis showed that the DMV/1639 and Mass-type strains were evolving under negative selection, whereas the Ark type viruses had evolved under positive selection. This data supports the hypothesis that live attenuated vaccine usage does play a role in the genetic profile of similar IB viruses in the field and phylogenetic network analysis can be used to identify vaccine and vaccine origin isolates, which is important for our understanding of the role live vaccines play in the evolutionary trajectory of those viruses.
Inhibition of Neuropathic Pain by Selective Ablation of Brainstem Medullary Cells Expressing the μ-Opioid Receptor (2001)

Neurons in the rostroventromedial medulla (RVM) project to spinal loci where the neurons inhibit or facilitate pain transmission. Abnormal activity of facilitatory processes may thus represent a mechanism of chronic pain. This possibility and the phenotype of RVM cells that might underlie experimental neuropathic pain were investigated. Cells expressing mu-opioid receptors were targeted with a single microinjection of saporin conjugated to the mu-opioid agonist dermorphin; unconjugated saporin and dermorphin were used as controls. RVM dermorphin-saporin, but not dermorphin or saporin, significantly decreased cells expressing mu-opioid receptor transcript. RVM dermorphin, saporin, or dermorphin-saporin did not change baseline hindpaw sensitivity to non-noxious or noxious stimuli. Spinal nerve ligation (SNL) injury in rats pretreated with RVM dermorphin-saporin failed to elicit the expected increase in sensitivity to non-noxious mechanical or noxious thermal stimuli applied to the paw. RVM dermorphin or saporin did not alter SNL-induced experimental pain, and no pretreatment affected the responses of sham-operated groups. This protective effect of dermorphin-saporin against SNL-induced pain was blocked by beta-funaltrexamine, a selective mu-opioid receptor antagonist, indicating specific interaction of dermorphin-saporin with the mu-opioid receptor. RVM microinjection of dermorphin-saporin, but not of dermorphin or saporin, in animals previously undergoing SNL showed a time-related reversal of the SNL-induced experimental pain to preinjury baseline levels. Thus, loss of RVM mu receptor-expressing cells both prevents and reverses experimental neuropathic pain. The data support the hypothesis that inappropriate tonic-descending facilitation may underlie some chronic pain states and offer new possibilities for the design of therapeutic strategies.
Development of Interactive Virtual Laboratories to Help Students Learn Difficult Concepts in Thermodynamics (2020)

He currently has research activity in areas related engineering education and is interested in integrating technology into effective educational practices and in promoting the use of higher-level cognitive skills in engineering problem solving.