gebhart/patrepeval huggingface dataset:
All-Clay Photonic Crystals (2008)

Hierarchically structured "all-clay" 1D and 3D inverse photonic crystals were fabricated, featuring the crystalline layered microstructure of the phyllosilicate Laponite combined with crystalline macroporosity on the submicron scale. By using simple hard-templating protocols based on monodisperse polystyrene spheres, periodic layered silicate and inverse opal architectures with photonic crystal properties are accessible, which exhibit reflectivities of the stop band in excess of 50%. The combination of intrinsic chemical functionality with structural color makes such hierarchical "all-clay" architectures potential scaffolds in color-tunable chemo-optical devices.
Efficient Hashing with Lookups in two Memory Accesses (2004)

The study of hashing is closely related to the analysis of balls and bins. It is well-known that instead of using a single hash function if we randomly hash a ball into two bins and place it in the smaller of the two, then this dramatically lowers the maximum load on bins. This leads to the concept of two-way hashing where the largest bucket contains $O(\log\log n)$ balls with high probability. The hash look up will now search in both the buckets an item hashes to. Since an item may be placed in one of two buckets, we could potentially move an item after it has been initially placed to reduce maximum load. with a maximum load of We show that by performing moves during inserts, a maximum load of 2 can be maintained on-line, with high probability, while supporting hash update operations. In fact, with $n$ buckets, even if the space for two items are pre-allocated per bucket, as may be desirable in hardware implementations, more than $n$ items can be stored giving a high memory utilization. We also analyze the trade-off between the number of moves performed during inserts and the maximum load on a bucket. By performing at most $h$ moves, we can maintain a maximum load of $O(\frac{\log \log n}{h \log(\log\log n/h)})$. So, even by performing one move, we achieve a better bound than by performing no moves at all.
Low efficiency droop in blue-green m-plane InGaN/GaN light emitting diodes (2010)

We investigated the electroluminescence and relatively external quantum efficiency (EQE) of m-plane InGaN/GaN light emitting diodes (LEDs) emitting at 480 nm to elucidate the droop behaviors in nitride-based LEDs. With increasing the injection current density to 100 A/cm2, the m-plane LEDs exhibit only 13% efficiency droop, whereas conventional c-plane LEDs suffer from efficiency droop at very low injection current density and the EQE of c-plane LEDs decrease to as little as 50% of its maximum value. Our simulation models show that in m-plane LEDs the absence of polarization fields manifest not only the hole distribution more uniform among the wells but also the reduction in electron overflow out of electron blocking layer. These results suggest that the nonuniform distribution of holes and electron leakage current due to strong polarization fields are responsible for the relatively significant efficiency droop of conventional c-plane LEDs.
Oxygen-17 NMR studies on alkylindanones: steric effects (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxygen-17 NMR studies on alkylindanones: steric effectsDavid W. Boykin, Russell L. Hertzler, John K. Delphon, and Edmund J. EisenbraunCite this: J. Org. Chem. 1989, 54, 6, 1418–1423Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/jo00267a033https://doi.org/10.1021/jo00267a033research-articleACS PublicationsRequest reuse permissionsArticle Views139Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ultrafast Non-Paraxial Autofocusing Pulses for High-Gradient Electron Acceleration (2015)

We present ultrafast non-paraxial autofocusing beams that exhibit abrupt, ultra-intense focusing in both space and time. We demonstrate their ability to linearly accelerate on-axis electrons with effective gradients exceeding 300 GeV/m.
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data (2014)

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
ChemInform Abstract: ENEHYDRAZINES. III. SYNTHESIS OF PYRAZOLIUM BETAINES BY CYCLOACYLATION OF ENEHYDRAZINES (1983)

Abstract Bei der Cycloacylierung von N 2 ‐dialkylsubstituierten Enhydrazinen wie (II), (IV), (VI), (VIII) mit den Kohlensäurederivaten (I) werden Pyrazoliumbetaine wie (III), (V), (VII), (IX) bzw. (X) gebildet.
High temperature, optically pumped, 1.55 μm VCSEL operating at 6 Gb/s (2003)

In this paper, we use a 980 nm laser to optically pump 1.55 /spl mu/m vertical cavity surface emitting lasers (VCSELs) and demonstrate record output power of 2 mW at 25/spl deg/C and a record operating temperature of 105/spl deg/C with 140 /spl mu/W output power. Single mode operation with a side mode suppression ratio (SMSR) of 61 dB was achieved and transmission over 25 km of fiber at a bit rate of 6 Gb/s was demonstrated.
Abstract 1272: Whole genome Crispr screening to identify potential SERD molecule resistance mechanisms (2019)

Metastatic breast cancer results in substantial morbidity and mortality for women afflicted with this disease. Approximately 80% of breast cancers express the estrogen receptor. The cancer cell survival and proliferation is driven by the activation of the estrogen receptor. SAR439859 is an effective endocrine therapy for breast cancer selectively and effectively degrading the estrogen receptor. A phase 1/2 study of SAR439859 alone and/or in combination with palbociclib in postmenopausal women with estrogen receptor positive advanced breast cancer was initiated last year by Sanofi.CRISPR/Cas9 is a recent and revolutionary technology for efficient and directed alterations of the genome. CRISPR allows users to introduce DNA double-strand breaks at precise locations in the genome using complementary guide RNAs (SgRNA). These double strand breaks can be repaired by non-homologous end joining DNA repair mechanism. This DNA repair mechanism is an error prone DNA repair process which can lead to gene invalidation.We aimed at investigating the potential SAR439859 resistance mechanisms. A better understanding of resistance mechanisms is needed to overcome this potential problem and to propose complementary therapeutic solutions. We conducted a whole genome CRISPR screening in a breast tumor cell line with a thermofisher commercial SgRNA library (ref: M04305) to identified genes involved in potential SAR439859 resistance phenomena. CRISPR screening steps will be presented from the cell line selections to results analysis.Citation Format: Christophe Marcireau, Karine Berthelot, Alice Williart, Hamida Fournet, Delphine Debono, Gilbert Thill, Helene Erasimus, Dorine Chassin, Christophe Lanneau, Veeanagouda Yaligara, Cecile Orsini, Michel Didier, Vincent Mikol, Monsif Bouaboula, Laurent Debussche. Whole genome Crispr screening to identify potential SERD molecule resistance mechanisms [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1272.
Hyaluronic Acid as a Protein Polymeric Carrier: An Overview and a Report on Human Growth Hormone (2015)

Hyaluronic acid (HA) is a natural polysaccharide primarily present in the vitreous humor and in cartilages where it plays a key structural role in organizing the cartilage extracellular matrix. HA is used in a wide range of applications including treatment of arthritis (as a viscosupplementation agent for joints) and in a variety of cosmetic injectable products. Its safety profile is thus well established. Thanks to its high biocompatibility and targeting properties, HA has also been investigated for use as a carrier of anticancer drugs and, recently, also of proteins. Its role in the last case is a particularly challenging one as dedicated coupling chemistries are required to preserve the protein’s conformation and activity. This study focuses on the state of the art on protein HAylation. New data from our laboratory on the local delivery of specific biologics to joints will also be outlined. Keywords: Arthritis, biopharmaceuticals, human growth hormone, hyaluronic acid, polymer conjugation, site-selective conjugation.
Studies of Chemistry and Diffusion on Silicon and Gallium Arsenide Surfaces Using Laser-Induced Thermal Desorption (1990)

Abstract : Surface chemistry and surface diffusion play pivotal roles in semiconductor processing and must be understood as electronic device dimensions approach the submicron level. In this project, basic time-dependent processes on silicon surfaces were examined using laser induced thermal desorption (LITD) and Fourier transform infrared (FTIR) spectroscopy. These techniques provided direct, quantitative measurements of surface coverage in real-time. Using LITD and FTIR techniques, emphasis was on a microscopic understanding of semiconductor surface reaction kinetics.
Inference for Generalized Linear Models via Alternating Directions and Bethe Free Energy Minimization (2015)

Generalized Linear Models (GLMs), where a random vector $\mathbf{x}$ is observed through a noisy, possibly nonlinear, function of a linear transform $\mathbf{z}=\mathbf{Ax}$ arise in a range of applications in nonlinear filtering and regression. Approximate Message Passing (AMP) methods, based on loopy belief propagation, are a promising class of approaches for approximate inference in these models. AMP methods are computationally simple, general, and admit precise analyses with testable conditions for optimality for large i.i.d. transforms $\mathbf{A}$. However, the algorithms can easily diverge for general $\mathbf{A}$. This paper presents a convergent approach to the generalized AMP (GAMP) algorithm based on direct minimization of a large-system limit approximation of the Bethe Free Energy (LSL-BFE). The proposed method uses a double-loop procedure, where the outer loop successively linearizes the LSL-BFE and the inner loop minimizes the linearized LSL-BFE using the Alternating Direction Method of Multipliers (ADMM). The proposed method, called ADMM-GAMP, is similar in structure to the original GAMP method, but with an additional least-squares minimization. It is shown that for strictly convex, smooth penalties, ADMM-GAMP is guaranteed to converge to a local minima of the LSL-BFE, thus providing a convergent alternative to GAMP that is stable under arbitrary transforms. Simulations are also presented that demonstrate the robustness of the method for non-convex penalties as well.
The Role of Erythropoietin in Vascular Endothelial Cells and Thrombosis. (2005)

Abstract Erythropoietin (EPO) is an essential glycoprotein hormone that regulates erythrocyte production in hematopoietic tissues by stimulating growth, preventing apoptosis, and inducing the differentiation of red blood cell precursors. Clinically, EPO has been extensively used to increase levels of hemoglobin in the treatment of patients with anemia due to chronic renal failure, cancer chemotherapy, and HIV therapy. Recent studies suggest that the function of EPO and its cognate receptor, EPOR, are not strictly limited to erythroid lineages. EPOR expression has been identified in nonhematopoietic cells and tissues including endothelial, neuronal, and tumor cells. Epoetins have shown benefit in correcting anemia in chronic kidney disease and in chemotherapy-associated anemia in cancer patients. However, the incidence of thrombosis appears to be higher in patients administered EPO versus controls transfused to comparable hemoglobin levels. In particular, incidences seem higher in oncological patients treated with EPO and receiving combined radiation and chemotherapy than in those receiving chemotherapy alone. To address the potential interaction and responsiveness of the vasculature to EPO, we evaluated EPO using vascular endothelial cell assays. Biochemical analysis (eg, receptor expression, ligand-receptor binding, and activation of signaling cascades) as well as cellular analysis (eg, proliferation, migration, and differentiation) will be discussed. To evaluate the effects of EPO on thrombosis we used the in vivo pulmonary micoemboli (ME) model. In this fibrinolysis model, a preformed 125I-fibrin microemboli with a defined particle size is infused into mice intravenously. Microemboli lodge primarily in the lungs and the rate of radioactivity lost is measured over time. Defects in fibrinolysis have been identified in mice lacking either tPA or uPA. Mice were exposed acutely or chronically to EPO and the dissolution of ME was tested. Mice were injected subcutaneously with either a single dose of EPO (2500 IU/kg) and for the chronic studies EPO (1200 IU/kg) or control buffer three times a week for three weeks. The residual radioactivity in the lungs was measured after 10 and 90 minutes. Red blood cell count, hemoglobin, and hematocrit were analyzed weekly to confirm EPO activity. Our results indicate that neither a single (acute) dose of EPO nor chronic treatment using EPO affected the rate of pulmonary fibrinolysis. This suggests that EPO treatment does not significantly impair the function of the pulmonary fibrinolytic system proteins (eg, uPA, tPA, plasminogen, and PAI-1) using the ME model. We cannot exclude EPO’s potential influence on other aspects of coagulation and fibrinolysis.
The asymmetric hydrogenation of heterocyclic ketones (2010)

Potassium-competitive acid blockers (P-CABs) containing an imidazo[1,2-a]pyridine/benzimidazole scaffold, respectively were prepared via asymmetric hydrogenation of aryl ketone intermediates in the presence of RuCl 2 [(S)-Xyl-P-Phos][(S)-DAIPEN]. The enantioselective synthesis of BYK 405879 was successfully implemented on Kg scale.
Further manifestations of abortive transformation of bhk 21 cells by polyoma virus (1971)

Abstract Abortive transformation of layer cultures of BHK 21 cells by polyoma virus has been studied using serum‐depleted medium. High doses of partially purified infectious virus, in the absence of serum, stimulate the majority of the cells to synthesize DNA while empty capsids do not. The onset of DNA synthesis occurs approximately 28 h after infection, and in medium containing 0.8% γ‐depleted serum, can be followed by one round of mitoses. A temporary loss of oriented arrangement of cells is also observed commencing 25 to 30 h after infection. Abortively transformed cells resemble stably transformed lines of BHK 21 cells in their requirements for the factors in serum operative in the control of growth.
Oxidation and reduction behavior of macrocyclic complexes of nickel. Electrochemical and electron spin resonance studies (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation and reduction behavior of macrocyclic complexes of nickel. Electrochemical and electron spin resonance studiesFrank V. Lovecchio, Ernest S. Gore, and Daryle H. BuschCite this: J. Am. Chem. Soc. 1974, 96, 10, 3109–3118Publication Date (Print):May 1, 1974Publication History Published online1 May 2002Published inissue 1 May 1974https://pubs.acs.org/doi/10.1021/ja00817a016https://doi.org/10.1021/ja00817a016research-articleACS PublicationsRequest reuse permissionsArticle Views1867Altmetric-Citations314LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The twist-bend nematic phase of bent mesogenic dimers and its mixtures (2016)

Binary mixtures of the twist-bend nematic-forming liquid crystal CB7CB with the prototypical rodlike liquid crystal 5CB exhibit a twist-bend nematic (NTB) phase with properties similar to those reported for neat CB7CB. The mixtures appear homogeneous, with no micronor nano-scale segregation evident at any concentration. The linear dependence of the phase transition temperature on concentration indicates that these binary mixtures are nearly ideal. However, a decrease in the viscosity with the addition of 5CB allows the characteristic twist-bend stripe textures to relax into a state of uniform birefringence. We confirm the presence of nanoscale modulations of the molecular orientation in the mixtures by freeze-fracture transmission electron microscopy (FFTEM), further evidence of their twist-bend nature. We devise and implement a statistical approach to quantitatively measure the ground state pitch of the twist-bend phase and its mixtures using FFTEM. The addition of 5CB generally shifts the measured ground-state pitch distributions towards larger pitch. Interestingly, the pitch appears to increase discontinuously by ~10 nm at the 50 wt% concentration of 5CB, indicating that the twist-bend phase undergoes a structural transition at higher 5CB concentrations.
First measurement of the $CP$-violating phase in $B^0_s\to J/\psi(\to e^+e^-)\phi$ decays (2021)

A flavour-tagged time-dependent angular analysis of B-s(0) -&gt; J/Psi phi decays is presented where the J/Psi meson is reconstructed through its decay to an e(+)e(-) pair. The analysis uses a sample of pp collision data recorded with the LHCb experiment at centre-of-mass energies of 7 and 8TeV, corresponding to an integrated luminosity of 3 fb(-1). The CP-violating phase and lifetime parameters of the B-s(0) s system are measured to be phi(s) = 0.00 +/- 0.28 +/- 0.07 rad, Delta Gamma(s) = 0.115 +/- 0.045 +/- 0.011 ps(-1) and Delta Gamma(s) = 0.608 +/- 0.018 +/- 0.012 ps(-1) where the first uncertainty is statistical and the second systematic. This is the first time that CP-violating parameters are measured in the B-s(0) -&gt; J/Psi phi decay with an e+e- pair in the final state. The results are consistent with previous measurements in other channels and with the Standard Model predictions.
Directed dynamic self-assembly of objects rotating on two parallel fluid interfaces (2002)

This paper describes dynamic self-assembly of millimeter-sized objects rotating at two parallel fluid interfaces and interacting with one another hydrodynamically, both in the plane of the interface and between the interfaces. The nature of hydrodynamic interactions between the objects rotating on different interfaces and, consequently, the morphologies of the ordered structures that self-assemble, depend on the sizes and the three-dimensional shapes of the rotating particles. Large particles rotating on one interface (“templates”) can direct the self-assembly of smaller particles (“substrates”) on the other interface. Two examples of directed self-assembly are discussed: (i) selective dimerization of disk spinning on the lower interface under the influence of cylinders rotating on the upper interface, and (ii) assembly of “substrate” rectangles into a pattern of squares that is identical with the pattern formed by the “template” squares. General, qualitative characteristics of the vortex–vortex interactions between objects of complex shapes are discussed.
The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice (2010)

Mucormycosis is a fungal infection of the sinuses, brain, or lungs that causes a mortality rate of at least 50% despite first-line therapy. Because angioinvasion is a hallmark of mucormycosis infections, we sought to define the endothelial cell receptor(s) for fungi of the order Mucorales (the fungi that cause mucormycosis). Furthermore, since patients with elevated available serum iron, including those with diabetic ketoacidosis (DKA), are uniquely susceptible to mucormycosis, we sought to define the role of iron and glucose in regulating the expression of such a receptor. Here, we have identified glucose-regulated protein 78 (GRP78) as what we believe to be a novel host receptor that mediates invasion and damage of human endothelial cells by Rhizopus oryzae, the most common etiologic species of Mucorales, but not Candida albicans or Aspergillus fumigatus. Elevated concentrations of glucose and iron, consistent with those seen during DKA, enhanced GRP78 expression and the resulting R. oryzae invasion and damage of endothelial cells in a receptor-dependent manner. Mice with DKA, which have enhanced susceptibility to mucormycosis, exhibited increased expression of GRP78 in sinus, lungs, and brain compared with normal mice. Finally, GRP78-specific immune serum protected mice with DKA from mucormycosis. These results suggest a unique susceptibility of patients with DKA to mucormycosis and provide a foundation for the development of new therapeutic interventions for these deadly infections.
ChemInform Abstract: The Oxidation Reaction of Lead Sulfate Formed at the Interface Between the Grid and the Active Material. (1989)

Abstract Lead dioxide film electrodes are prepared using gold substrates and discharged in H 2 SO 4 under different conditions.