gebhart/patrepeval huggingface dataset:
Co-immobilization of a Rh Catalyst and a Keggin Polyoxometalate in the UiO-67 Zr-Based Metal–Organic Framework: In Depth Structural Characterization and Photocatalytic Properties for CO2 Reduction (2020)

The Keggin-type polyoxometalate (POM) PW<sub>12</sub>O<sub>40</sub><sup>3-</sup> and the catalytic complex Cp*Rh(bpydc)Cl<sub>2</sub> (bpydc = 2,2'-bipyridine-5,5'-dicarboxylic acid) were coimmobilized in the Zr(IV) based metal organic framework UiO-67. The POM is encapsulated within the cavities of the MOF by <i>in situ</i> synthesis, and then, the Rh catalytic complex is introduced by postsynthetic linker exchange. Infrared and Raman spectroscopies, <sup>31</sup>P and <sup>13</sup>C MAS NMR, N<sub>2</sub> adsorption isotherms, and X-ray diffraction indicate the structural integrity of all components (POM, Rh-complex and MOF) within the composite of interest (PW<sub>12</sub>,Cp*Rh)@UiO-67. DFT calculations identified two possible locations of the POM in the octahedral cavities of the MOF: one at the center of a UiO-67 pore with the Cp*Rh complex pointing toward an empty pore and one off-centered with the Cp*Rh pointing toward the POM. <sup>31</sup>P-<sup>1</sup>H heteronuclear (HETCOR) experiments ascertained the two environments of the POM, equally distributed, with the POM in interaction either with the Cp* fragment or with the organic linker. In addition, Pair Distribution Function (PDF) data were collected on the POM@MOF composite and provided key evidence of the structural integrity of the POM once immobilized into the MOF. The photocatalytic activity of the (PW<sub>12</sub>,Cp*Rh)@UiO-67 composite for CO<sub>2</sub> reduction into formate and hydrogen were evaluated. The formate production was doubled when compared with that observed with the POM-free Cp*Rh@UiO-67 catalyst and reached TONs as high as 175 when prepared as thin films, showing the beneficial influence of the POM. Finally, the stability of the composite was assessed by means of recyclability tests. The combination of XRD, IR, ICP, and PDF experiments was essential in confirming the integrity of the POM, the catalyst, and the MOF after catalysis.
Edge-based active queue management (2006)

In this paper, a new framework of active queue management, namely, edge-based active queue management (EAQM), is proposed. Conventional AQM schemes are required to be deployed at all routers in the network, and this involves significant upgrading to current drop-tail routers. The new approach only needs to modify the edge routers and at the same time provides similar or better performance as compared to conventional AQM schemes. Furthermore, EAQM can reduce the throughput bias against TCP connections with longer round trip times, and this cannot be achieved by current available AQM approaches.
Filoviruses: Hemorrhagic Fevers (2012)

The family Filoviridae contains at least eight distinct viruses, grouped into three genera. The marburgviruses Marburg and Ravn and the ebolaviruses Bundibugyo, Ebola, Sudan, and Taï Forest cause severe and often lethal viral hemorrhagic fever in humans. The natural hosts of these viruses are unclear, but infectious Marburg and Ravn viruses could be isolated from frugivorous bats, suggesting that the ecological distribution of particular bats define the geographic occurence of filoviral disease. Infections occur when humans come in direct or indirect contact with bats or nonhuman primates (thought to be infected via contact with bats) or their tissues. Consequently, disease can be prevented if such contacts are limited. There is currently no FDA-approved vaccine for the prevention or antiviral for the treatment of filovirus infections.
Development of New Camphor‐Based N,S Chiral Ligands and Their Application in Transfer Hydrogenation (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Pseudo-complementary PNA actuators as reversible switches in dynamic DNA nanotechnology (2013)

The structural reorganization of nanoscale DNA architectures is a fundamental aspect in dynamic DNA nanotechnology. Commonly, DNA nanoarchitectures are reorganized by means of toehold-expanded DNA sequences in a strand exchange process. Here we describe an unprecedented, toehold-free switching process that relies on pseudo-complementary peptide nucleic acid (pcPNA) by using a mechanism that involves double-strand invasion. The usefulness of this approach is demonstrated by application of these peptide nucleic acids (PNAs) as switches in a DNA rotaxane architecture. The monomers required for generating the pcPNA were obtained by an improved synthesis strategy and were incorporated into a PNA actuator sequence as well as into a short DNA strand that subsequently was integrated into the rotaxane architecture. Alternate addition of a DNA and PNA actuator sequence allowed the multiple reversible switching between a mobile rotaxane macrocycle and a stationary pseudorotaxane state. The switching occurs in an isothermal process at room temperature and is nearly quantitative in each switching step. pcPNAs can potentially be combined with light- and toehold-based switches, thus broadening the toolbox of orthogonal switching approaches for DNA architectures that open up new avenues in dynamic DNA nanotechnology.
New routes to flame retard polyamide 6,6 for electrical applications (2012)

Polyamide 6,6 is used in many industrial fields such as housing materials, transport or electrical engineering applications. Due to its chemical composition, this polymer is easily flammable. As far as the main applications concern electrical and electronic equipments, its flame-retardant properties become an important requirement. The most discriminating tests are the limiting oxygen index, UL94 and glow wire flammability index. The aim is to obtain high limiting oxygen index values, V0 rating at UL94 test for 1.6- or 0.8-mm-thick samples and a validation at 960°C of the glow wire flammability index. The usual way to fire retard polyamide 6,6 consists of incorporating an important loading of fire-retardant additives, which often reduce the intrinsic properties of the polymer. It is also difficult to combine a thin polymer thickness (e.g. 0.8 mm) and a high amount of additives because of processing issues. In this article, we first carried out a rapid screening to determine the best fire retardant for polyamide 6,6 and its optimized amount to achieve the previously defined fire retardant properties. It was shown that an amount of 23% of aluminium diethylphosphinate Exolit OP1230 allows reaching the requirements. Then, carrying out two different surface treatments (coating of polysiloxanes by plasma-enhanced chemical vapour deposition and use of an intumescent waterborne varnish), we have tried to reach the same results. It was shown that the use of surface treatment alone does not allow reaching the objectives. As a consequence, the combination of the bulk approach at low loadings with the surface treatment was investigated. This new route allows the combination of the condensed phase mechanism of the intumescent barrier with the gas phase mechanism of the OP1230 and leads to very good results: the use of 5% of the flame-retardant additives combined with a 100-µm-thick waterborne intumescent varnish leads to better results than a 23% of additive loading.
Gene Therapy for Hemoglobinopathies (2018)

Gene therapy for β-thalassemia and sickle-cell disease is based on transplantation of genetically corrected, autologous hematopoietic stem cells. Preclinical and clinical studies have shown the safety and efficacy of this therapeutic approach, currently based on lentiviral vectors to transfer a β-globin gene under the transcriptional control of regulatory elements of the β-globin locus. Nevertheless, a number of factors are still limiting its efficacy, such as limited stem-cell dose and quality, suboptimal gene transfer efficiency and gene expression levels, and toxicity of myeloablative regimens. In addition, the cost and complexity of the current vector and cell manufacturing clearly limits its application to patients living in less favored countries, where hemoglobinopathies may reach endemic proportions. Gene-editing technology may provide a therapeutic alternative overcoming some of these limitations, though proving its safety and efficacy will most likely require extensive clinical investigation.
Scalable 10Gbps TCP/IP Stack Architecture for Reconfigurable Hardware (2015)

TCP/IP is the predominant communication protocol in modern networks but also one of the most demanding. Consequently, TCP/IP offload is becoming increasingly popular with standard network interface cards. TCP/IP Offload Engines have also emerged for FPGAs, and are being offered by vendors such as Intilop, Fraunhofer HHI, PLDA and Dini Group. With the target application being high-frequency trading, these implementations focus on low latency and support a limited session count. However, many more applications beyond high-frequency trading can potentially be accelerated inside an FPGA once TCP with high session count is available inside the fabric. This way, a network-attached FPGA on ingress and egress to a CPU can accelerate functions such as encryption, compression, memcached and many others in addition to running the complete network stack. This paper introduces a novel architecture for a 10Gbps line-rate TCP/IP stack for FPGAs that can scale with the number of sessions and thereby addresses these new applications. We prototyped the design on a VC709 development board, demonstrating compatibility with existing network infrastructure, operating at full 10Gbps throughput full-duplex while supporting 10,000 sessions. Finally, the design has been described primarily using high-level synthesis, which accelerates development time and improves maintainability.
Silver(I)‐Catalyzed Diastereoselective Synthesis of anti‐1,2‐Hydroxyboronates (2015)

Abstract A catalytic protocol for the diastereoselective synthesis of anti ‐1,2‐hydroxyboronates is described. The process provides access to secondary alkyl organoborons. The deborylative 1,2‐addition reactions of alkyl 1,1‐diborons proceed in the presence of a silver(I) salt with either KO t Bu or n BuLi as an activator. The catalytic diastereoselective protocol can be extended to aryl, alkenyl, and alkyl aldehydes with up to 99:1 d.r.
Experience from the selection and nutritional preparation for Expedition ICE MAIDEN: the first successful all-female unassisted Antarctic traverse (2019)

The selected Ex IM team demonstrated favourable training-associated body composition changes. Training-associated weight loss informed the expeditionary diet design.
Comparison of artificial neural networks with pattern recognition and image processing (1989)

This paper presents a comparison between the field of artificial neural network and the field of image processing and pattern recognition. It shows that some of the adaptive processing algorithms for pattern recognition and image processing, in terms of neural networks, can be seen as adaptive heteroassociative and autoassociative memories, respectively. The similarities and differences between these two fields are addressed.
Effects of Pre-Charged Hydrogen on the Mechanical and Thermal Behavior of Zr-Ti-Ni-Cu-Be Bulk Metallic Glass Alloys (2001)

The effects of pre-charged hydrogen on the deformation, fracture and thermal behavior of a Zr–Ti–Ni–Cu–Be bulk metallic glass were investigated. The glass transition and crystallization temperatures were shifted to higher values with increasing hydrogen charging indicating sluggish kinetics. Flow stress was increased and fracture toughness was degraded after hydrogen charging. The atomic jump process which underlies the plastic deformation is believed to be retarded by hydrogen resulting in embrittlement.
Molecular basis of cardiac troponin T isoform heterogeneity in rabbit heart. (1994)

In the rabbit heart, multiple isoforms of cardiac troponin T (cTnT1 through cTnT5, from largest in size to smallest), a protein essential for calcium-regulated myofibrillar ATPase activity, have been identified, and a correlation has been found between these isoforms and myofilament sensitivity to calcium. We have sought to establish the molecular basis of this diversity. Restriction-digest analysis of genomic DNA has indicated that the rabbit cTnT gene is a single-copy gene. cTnT cDNA clones were isolated from cDNA libraries, yielding a consensus sequence for the protein. Newborn rabbit heart cDNAs, obtained using the reverse-transcriptase polymerase chain reaction (RT-PCR), were amplified using primers derived from this cDNA. Three full-length cDNAs that differed by the inclusion or exclusion of three short nucleotide sequences within the cDNAs were obtained. Amplification in the 5' half of the cDNAs confirmed that multiple cTnT products arose because of the variable inclusion of an 18- and a 30-nt sequence. The 30-nt sequence has homology with previously described alternatively spliced exons in rat and chicken cTnT, whereas the 18-nt sequence has not been described previously. RT-PCR in the 3' half of the cDNAs confirmed an additional region of heterogeneity: the presence, in part or in full, or absence of a 9-nt region, which matches the alternatively spliced exon 12 described for rat cTnT. In vitro transcription and translation of four cDNA clones containing both the 18- and 30-nt sequences, the 30-nt sequence, the 18-nt sequence, or neither generated protein isoforms that comigrated with cTnT1, cTnT2, cTnT3, and cTnT4, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Rear end collision mitigation system for an automotive vehicle : patent pending (2016)

The present invention relates to a system (1) and method for autonomous rear impact mitigation in a host vehicle (2) having a brake system (4) and a steering system (5). The relative motion paramet ...
Surface characteristics and properties of lumbrokinase‐immobilized polyurethane (1995)

Potent and novel fibrinolytic enzymes (lumbrokinase [LK]) were extracted from the earthworm, Lumbricus rubellus. These enzymes were very stable and showed greater antithrombotic activity than other currently used fibrinolytic proteins. An LK fraction showing the most potent fibrinolytic activity was immobilized onto a polyurethane (PU) surface to investigate its enzymatic activity and antithrombotic activity. A methanol-extracted PU surface was coated with 3% (wt/vol) maleic anhydride methylvinyl ether copolymer (MAMEC)/tetrahydrofuran (THF) solution, and the surface was incubated in an LK solution/phosphate-buffered saline (PBS, pH 7.4). The surface properties were characterized by attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), electron spectroscopy for chemical analysis (ESCA), and dynamic contact angle. The stability of immobilized LK was determined by caseinolytic activity assay and the specificity of immobilized LK on fibrinogen/fibrin was observed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). The antithrombotic activity of immobilized LK was evaluated using an ex vivo rabbit A-A shunt experiment. LK immobilization was confirmed by ATR-FTIR and ESCA. Immobilized LK demonstrated stable proteolytic activity during various incubation periods. Immobilized LK proteolyzed fibrinogen and fibrin almost specifically, while it hardly hydrolyzed other plasma proteins including plasminogen and albumin. In the ex vivo A-A shunt experiment, the LK-immobilized surface significantly prolonged occlusion time over control surfaces. This is primarily due to the high thrombolytic activity of immobilized LK. In this work, a highly efficient surface modification method on the PU surface was developed, and this LK immobilization technique will be very useful in improving the blood compatibility of blood-contacting devices.
Hyperbranched polyhedral oligomeric silsesquioxane (HB‐POSS) nanomaterials for high transmission and radiation‐resistant space and solar applications (2013)

ABSTRACT Hyperbranched polycarbosiloxanes and polysiloxanes with octafunctional polyhedral oligomeric silsesquioxane (POSS) branchpoints and curable alkoxysilane or silanol end‐groups were formulated with linear polysiloxanes to fabricate transparent and robust nanostructured POSS‐containing materials for use in a range of high performance space and solar applications. The effect of methyl vs. phenyl content, architecture and linear polysiloxane mass on transmission, thermal, physical, and proton, electron and UV radiation resistance properties was determined, and the physical properties of the nanomaterials were tailored to produce adhesives, or rigid or flexible coatings as desired. The methyl formulations showed superior electron resistance relative to a commercial space control material and to a POSS‐free HB polymer control material, even when directly exposed to radiation in coating form, whereas the phenyl formulations were shown to have inferior electron and UV resistance. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 3849–3861, 2013
Particle-bound phytochrome: Differential pigment release by surfactants, ribonuclease and phospholipase C (1976)

Surfactants and hydrolytic enzymes were used to probe the nature of the constituents) to which phytochrome binds in paniculate fractions from red-irradiated Cucurbita. [14C]-choline and [3H]-uridine pre-labelled tissue was used to monitor the release of phospholipids and RNA by these agents. Ribonuclease (RNase) digestion of 20,000×g pellets eliminates both the phytochrome and ribonucleoprotein (RNP) which cosediment at 31S. Little [14C]-choline occurs in the 31S fraction and the amount is not changed by RNase digestion. This is further evidence that phytochrome binds directly to the RNP in the 31S fraction rather than to any membranous material present. The distribution profile of the RNA in a second ( =‘heavy’) phytochrome fraction does not correlate with that of the pigment. This suggests that the phytochrome in this fraction is not bound to RNP. The RNA is of ribosomal origin but much less degraded than that of the 31S RNP and is resistant to RNase digestion. Phospholipase C releases>80% of the [14C]-choline from the ‘heavy’ fraction without freeing phytochrome. This indicates that the pigment does not bind to the polar head groups of the membrane phospholipids present. Low concentrations of deoxycholate dissociate phytochrome from this fraction without releasing substantial quantities of integral membrane proteins or phospholipids. Some RNP is dislodged by the surfactant but the phytochrome and RNP are not released as a complex. The data suggest that the pigment in the ‘heavy’ fraction may be loosely bound to a protein constituent rather than to RNP or polar phospholipids.
A microfabricated steel and glass radiation detector with inherent wireless signaling (2010)

This paper describes an investigation of the performance compromises imposed by a manufacturing approach that utilizes lithographic micromachining processes to fabricate a wireless beta/gamma radiation detector. The device uses in-package assembly of stainless steel electrodes and glass spacers. These elements are micromachined using photochemical etching and powder blasting, respectively. The detector utilizes a commercial, TO-5 package that is hermetically sealed at 760 Torr with an Ar fill-gas. Gas microdischarges between the electrodes, which are initiated by the radiation, transmit wideband wireless signals. The detector diameter and height are 9 and 9.6 mm, respectively, and it weighs 0.97 g. The device performance has been characterized using various sealed, radioisotope sources, e.g., 30–99 µCi from 137Cs (which is a beta and gamma emitter) and 0.1 µCi from 90Sr (which is a pure beta emitter). It has a measured output of >15.5 counts s−1 when in close proximity to 99 µCi from 137Cs. The wireless signaling spans 1.25 GHz at receiving antenna-to-detector distances >89 cm, when in close proximity to a 0.1 µCi 90Sr source. The estimated intrinsic detection efficiency (i.e. with the background rate subtracted) is 3.34% as measured with the biasing arrangement described in the paper.
ChemInform Abstract: SYNTHESIS AND MOLECULAR STRUCTURE OF AN AMINOPHOSPHORANIDE TRANSITION‐METAL ADDUCT. FIRST TRANSITION‐METAL DERIVATIVE HAVING A CYCLIC N‐P(V)‐M ARRANGEMENT (1981)

Abstract Die Reaktion von Methyllithium mit den kationischen Komplexen (I) liefert die Produkte (II) mit dem neuen N‐P‐M‐Dreiring.
ChemInform Abstract: TRANSITION METAL‐METHYLENE COMPLEXES. PART 32. BREAKING A METAL‐METAL TRIPLE BOND BY CHELATING DIAZOALKANE BRIDGES (1982)

Abstract Der Molybdänkomplex (I) reagiert mit dem Diazoketon (II) unter Spaltung der Metall‐Metall‐Bindung zum Komplex (III), dessen Struktur durch eine Röntgenstrukturanalyse gesichert wird.
Infection of B lymphocytes by the human immunodeficiency virus and their susceptibility to cytotoxic cells (1988)

The T4 molecule (CD4) is an important component of the human immunodeficiency virus (HIV) receptor. As yet, no other component has been demonstrated. We report here that two cell lines, a B lymphoblastoid cell line (Gupta) and a glial cell line (HEB) derived from human embryonal brain tissue, are productively infectable with two distinct isolates of HIV as judged by electron microscopy and immunological and virological studies. These two cell lines do not display detectable surface CD4 glycoprotein. However, using S1 nuclease analysis, we have found that both cell lines do express low levels of CD4 mRNA. Neither of them produced syncytia formation upon HIV infection, a recognized feature of HIV-infected cells strongly expressing the CD4 glycoprotein. It is conceivable that the CD4 mRNA is translated, resulting in meager surface expression of CD4 molecules undetectable by conventional techniques. Therefore, infection with HIV may be one of the most sensitive methods of demonstrating low levels of CD4 expression by human cells. Furthermore, HIV-infected Gupta cells have here been shown to be more susceptible to the lytic activity of natural killer (NK) cells than their uninfected counterparts. These phenomena may be important for pathogenesis of HIV-associated disorders.
IL-2 DEPENDENT RAPAMYCIN RESISTENT SIGNALS ARE REQUIRED FOR TOLERANCE INDUCTION AND T CELL APOPTOSIS (1998)

665 Cytokine driven immune regulation may play a critical role in peripheral tolerance. We studied the allograft response in recipient mice that are deficient for both IL-2 and IL-4 (DKO). DKO recipient mice (H-2b) vigorously reject fully MHC mismatched DBA/2J (H-2d) islet allografts (MST 17±7 days, n=8) with only slight delay compared to wild type (wt) controls (13±4 days, n=7). However, DKO recipients are totally refractory to the induction of transplantation tolerance. Rapamycin(0.2 mg/kg/day for 14 days) uniformly induced permanent engraftment of DBA/2J islet allografts in wt 129/J mice (>100 days, n=4). In contrast, all rapamycin treated DKO recipient mice rejected the islet allografts(27±9 days, n=5), albeit the rejection was delayed compared with untreated controls. Analysis for the failure of engraftment in DKO mice demonstrated that activation induced deletion of Vβ8+ T cells in vivo in response to superantigen SEB was severely impaired in DKO mice and that alloantigen primed lymphocytes from IL-2 deficient mice but not in IL-4 deficient mice failed to undergo activation induced and Fas mediated apoptosis in vitro. Our data establish that a rapamycin resistant IL-2 driven signal is required for tolerance induction. It seems likely that rapamycin blocks IL-2 delivered proliferative but not apoptotic signals and clonal contraction through activation induced apoptosis (AIA) is an essential process in tolerance induction. Apparently, IL-2 among various T cell growth factors plays an unique role in priming of activated T cells for AIA.