gebhart/patrepeval huggingface dataset:
The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma. (2001)

Patients undergoing Whipple resection for pancreatic adenocarcinoma survive longer if their cancers express SMAD4.
Enhanced photogalvanic current in topological insulators via Fermi energy tuning (2016)

We achieve the enhancement of the circular photogalvanic effect arising from the photoinjection of spins in topological insulator thin films by tuning the Fermi level $({E}_{\mathrm{F}})$. A series of ${({\mathrm{Bi}}_{1\ensuremath{-}x}{\mathrm{Sb}}_{x})}_{2}{\mathrm{Te}}_{3}$ thin films were tailored so that the Fermi energy ranges above 0.34 eV to below 0.29 eV of the Dirac point, i.e., from the bulk conduction band bottom to the valence band top through the bulk in-gap surface-Dirac cone. The circular photogalvanic current, indicating a flow of spin-polarized surface-Dirac electrons, shows a pronounced peak when the ${E}_{\mathrm{F}}$ is set near the Dirac point and is also correlated with the carrier mobility. Our observation reveals that there are substantial scatterings between the surface-Dirac and bulk state electrons in the generation process of spin-polarized photocurrent, which can be avoided by designing the electronic structure in topological insulators.
Evaluation of Corneal Neovascularization Using Optical Coherence Tomography Angiography in Patients With Limbal Stem Cell Deficiency (2017)

OCTA is a powerful tool for objective evaluation of vascularization in the anterior and posterior segments of the eye. We have demonstrated that OCTA can visualize corneal neovascularization in patients with corneal diseases more clearly than slit-lamp photography.
Comparative response assessment by total serum IgM and IgM M-component in Waldenstrom’s macroglobulinemia. (2012)

e18575 Background: Changes in total IgM and the electrophoretically determined IgM M-component are used as surrogate serum response markers in Waldenstrom’s Macroglobulinemia (WM). Their ability to reflect underlying disease burden changes have not been compared. Methods: 73 rituximab-naïve patients were studied who underwent rituximab-based therapy on a study, and for whom serial total serum IgM levels, IgM M-component, and bone marrow (BM) assessments were available. Baseline: Median age 61 years; serum IgM 3,960 mg/dL; IgM M-component 2.55 g/dL; BM disease by core biopsy 60%. 5 patients had serum IgM levels &lt;1,000 mg/dL, and 23 &gt; 5,000 mg/dL. 39 patients had adenopathy and/or splenomegaly by baseline CT scans. Post-therapy, serum IgM declined from 3,960 to 1,800 mg/dL (p&lt;0.0001); IgM M-component from 2.55 to 1.28 g/dL (p&lt;0.0001); and BM involvement from 60% to 10% (p&lt;0.0001). Among 39 patients with extramedullary disease, post-therapy CT scans were improved for 18, unchanged for 14, and worse for 7. Results: By linear regression analysis, reductions in serum total IgM and IgM M-component correlated with decreased BM disease involvement, though were relatively moderate (r=0.4490, p&lt;0.0001; and r=0.4051; p=0.0004, respectively). To assess the difference between serum IgM and IgM M-component for correlation with BM response, an r to z transformation was performed. Serum IgM and IgM M-component were not significantly different as predictors for BM response (p=0.3745). Moreover, total serum IgM and the IgM M-component were poor estimators of BM response in patients with IgM levels &lt;1,000 mg/dL (r=0.3635, p=0.2815 for serum IgM; r=0.1869, p=0.4672 for IgM M-component) or &gt;5,000 mg/dL (r=0.0762, p=0.2022 for serum IgM; r=0.0306, p=0.4246 for IgM M-component). Extramedullary disease presence had no impact on serum IgM or IgM M-component correlations with BM disease involvement. Conclusions: Serum IgM levels and IgM M-component show similar correlations to changes in BM disease burden following therapy in WM patients, though overall the strength of these correlations are moderate, and particularly poor among patients with either low (&lt;1,000 mg/dL) or high (&gt;5,000 mg/dL) serum IgM levels.
Quantitation of the main constituents of vanilla by reverse phase HPLC and ultra‐high‐pressure‐liquid‐chromatography with UV detection: Method validation and performance comparison (2009)

Vanilla's main constituents, i. e., vanillin, para-hydroxybenzaldehyde, and their corresponding acids, can be easily quantified by RP LC with UV detection and external calibration. This paper describes two methods that were developed using HPLC and ultra-high-pressure LC (UHPLC), respectively, and validated according to the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). Both methods were highly specific, exhibited good linearities with high precision, and achieved good accuracies of quantitative results. The UHPLC method was more sensitive, five times shorter, and gave better peak resolutions than the HPLC alternative.
Robust cooperative sensing via state estimation in cognitive radio networks (2011)

Cooperative sensing, a key enabling technology for dynamic spectrum access, is vulnerable to various sensing-targeted attacks, such as the primary user emulation or spectrum sensing data falsification. These attacks can easily disrupt the primary signal detection process, thus crippling the operation of dynamic spectrum access. While such sensing-targeted attacks can be easily launched by an attacker, it is very challenging to design a robust cooperative spectrum sensing scheme due mainly to the practical constraints inherent in spectrum sensing, particularly the shared/open nature of the wireless medium and the unpredictability of signal propagation. In this paper, we develop an efficient, yet simple attack detection framework, called IRIS (robust cooperatIve sensing via iteRatIve State estimation), that safeguards the incumbent detection process by checking the consistency among sensing reports via the estimation of system states, namely, the primary user's transmit-power and path-loss exponent. The key insight behind the design of IRIS is that the sensing results are governed by the network topology and the law of signal propagation, which cannot be easily compromised by an attacker. Consequently, the sensing reports must demonstrate consistency among themselves in estimating system states. Our analytical and simulation results show that, by performing consistency-checks, IRIS provides high attack-detection capability, and preserves satisfactory performance in estimating the system states even under very challenging attack scenarios. Based on these observations, we propose a new incumbent detection rule that can further improve the spectrum efficiency. IRIS can be readily deployed in infrastructure-based cognitive radio networks, such as IEEE 802.22 WRANs, with manageable processing and communication overheads.
Metal ion initiated charge-transfer photopolymerization of tetrahydrofuran. A mechanistic investigation (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal ion initiated charge-transfer photopolymerization of tetrahydrofuran. A mechanistic investigationMichael E. Woodhouse, Frederick D. Lewis, and Tobin J. MarksCite this: J. Am. Chem. Soc. 1982, 104, 21, 5586–5594Publication Date (Print):October 1, 1982Publication History Published online1 May 2002Published inissue 1 October 1982https://pubs.acs.org/doi/10.1021/ja00385a004https://doi.org/10.1021/ja00385a004research-articleACS PublicationsRequest reuse permissionsArticle Views634Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Editorial Introduction to TiiS Special Category Article: Practitioners’ Toolbox (2022)

No abstract available.
Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long‐term environmental enrichment (2002)

Abstract Neurons are continually born from endogenous stem cells and added to the dentate gyrus throughout life, but adult hippocampal neurogenesis declines precipitously with age. Short‐term exposure to an enriched environment leads to a striking increase in new neurons, along with a substantial improvement in behavioral performance. Could this plastic response be relevant for explaining the beneficial effects of leading “an active life” on brain function and pathology? Adult hippocampal neurogenesis in mice living in an enriched environment from the age of 10 to 20 months was fivefold higher than in controls. Relatively, the increase in neuronal phenotypes was entirely at the expense of newly generated astrocytes. This cellular plasticity occurred in the context of significant improvements of learning parameters, exploratory behavior, and locomotor activity. Enriched living mice also had a reduced lipofuscin load in the dentate gyrus, indicating decreased nonspecific age‐dependent degeneration. Therefore, in mice signs of neuronal aging can be diminished by a sustained active and challenging life, even if this stimulation started only at medium age. Activity exerts not only an acute but also a sustained effect on brain plasticity.
Pituitary Adenylate Cyclase-Activating Polypeptide Is a Potent Inhibitor of the Growth of Light Chain-Secreting Human Multiple Myeloma Cells (2006)

Multiple myeloma represents a malignant proliferation of plasma cells in the bone marrow, which often overproduces immunoglobulin light chains. We have shown previously that pituitary adenylate cyclase-activating polypeptide (PACAP) markedly suppresses the release of proinflammatory cytokines from light chain-stimulated human renal proximal tubule epithelial cells and prevents the resulting tubule cell injury. In this study, we have shown that PACAP suppresses the proliferation of human kappa and lambda light chain-secreting multiple myeloma-derived cells. The addition of PACAP suppressed light chain-producing myeloma cell-stimulated interleukin 6 (IL-6) secretion by the bone marrow stromal cells (BMSCs). A specific antagonist to either the human PACAP-specific receptor or the vasoactive intestinal peptide receptor attenuated the suppressive effect of PACAP on IL-6 production in the adhesion of human multiple myeloma cells to BMSCs. The secretion of IL-6 by BMSCs was completely inhibited by 10(-9) mol/L PACAP, which also attenuated the phosphorylation of both p42/44 and p38 mitogen-activated protein kinases (MAPK) as well as nuclear factor-kappaB (NF-kappaB) activation in response to the adhesion of multiple myeloma cells to BMSCs, whereas the inhibition of p42/44 MAPK signaling attenuated PACAP action. The signaling cascades involved in the inhibitory effect of PACAP on IL-6-mediated paracrine stimulation of light chain-secreting myeloma cell growth was mediated through the suppression of p38 MAPK as well as modulation of activation of transcription factor NF-kappaB. These findings suggest that PACAP may be a new antitumor agent that directly suppresses light chain-secreting myeloma cell growth and indirectly affects tumor cell growth by modifying the bone marrow milieu of the multiple myeloma.
Global Changes in Asexual Epichloë Transcriptomes during the Early Stages, from Seed to Seedling, of Symbiotum Establishment (2021)

Asexual <i>Epichloë</i> fungi are strictly seed-transmitted endophytic symbionts of cool-season grasses and spend their entire life cycle within the host plant. Endophyte infection can confer protective benefits to its host through the production of bioprotective compounds. Inversely, plants provide nourishment and shelter to the resident endophyte in return. Current understanding of the changes in global gene expression of asexual <i>Epichloë</i> endophytes during the early stages of host-endophyte symbiotum is limited. A time-course study using a deep RNA-sequencing approach was performed at six stages of germination, using seeds infected with one of three endophyte strains belonging to different representative taxa. Analysis of the most abundantly expressed endophyte genes identified that most were predicted to have a role in stress and defence responses. The number of differentially expressed genes observed at early time points was greater than those detected at later time points, suggesting an active transcriptional reprogramming of endophytes at the onset of seed germination. Gene ontology enrichment analysis revealed dynamic changes in global gene expression consistent with the developmental processes of symbiotic relationships. Expression of pathway genes for biosynthesis of key secondary metabolites was studied comprehensively and fuzzy clustering identified some unique expression patterns. Furthermore, comparisons of the transcriptomes from three endophyte strains in planta identified genes unique to each strain, including genes predicted to be associated with secondary metabolism. Findings from this study highlight the importance of better understanding the unique properties of individual endophyte strains and will serve as an excellent resource for future studies of host-endophyte interactions.
Control of Macroscopic Helicity by Using the Sergeants‐and‐Soldiers Principle in Organogels (2008)

The creation of well-defined homochiral helical ribbon structures in gel phase is presented. This is the first example of direct and complete control of microscopic and macroscopic helicity in the gel phase by application of the “sergeants-and-soldiers” principle by using an achiral gelator and a chiral trigger (see graphic).
Properties of ZnO(0001) layers grown by metalorganic chemical vapor deposition on GaN(0001) templates (2008)

Abstract The cover picture of this issue of physica status solidi (c) has been taken from the article [1].
Visible-Light-Driven Photocatalytic Hydrogen Generation on Nanosized TiO2-II Stabilized by High-Pressure Torsion (2016)

Photocatalytic activity of pure TiO2 is limited to ultraviolet (UV) light due to the wide bandgap of anatase and rutile phases. The bandgap of high-pressure phases of TiO2 can theoretically coincide with visible light, but these phases are unstable at ambient pressure. In this work, the high-pressure TiO2-II (columbite) phase with large fractions of oxygen vacancies was stabilized by inducing plastic strain to anatase under 6 GPa. The material could absorb visible light as a consequence of bandgap narrowing by ∼0.7 eV. Formation of nanosized TiO2-II enhanced the hydrogen generation efficiency under visible light, and the efficiency improved after removing the oxygen vacancies by annealing.
Rifapentine With and Without Moxifloxacin for Pulmonary Tuberculosis in People With Human Immunodeficiency Virus (S31/A5349) (2022)

NCT02410772.
Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy (2012)

Central serous chorioretinopathy (CSCR) is a vision-threatening eye disease with no validated treatment and unknown pathogeny. In CSCR, dilation and leakage of choroid vessels underneath the retina cause subretinal fluid accumulation and retinal detachment. Because glucocorticoids induce and aggravate CSCR and are known to bind to the mineralocorticoid receptor (MR), CSCR may be related to inappropriate MR activation. Our aim was to assess the effect of MR activation on rat choroidal vasculature and translate the results to CSCR patients. Intravitreous injection of the glucocorticoid corticosterone in rat eyes induced choroidal enlargement. Aldosterone, a specific MR activator, elicited the same effect, producing choroid vessel dilation -and leakage. We identified an underlying mechanism of this effect: aldosterone upregulated the endothelial vasodilatory K channel KCa2.3. Its blockade prevented aldosterone-induced thickening. To translate these findings, we treated 2 patients with chronic nonresolved CSCR with oral eplerenone, a specific MR antagonist, for 5 weeks, and observed impressive and rapid resolution of retinal detachment and choroidal vasodilation as well as improved visual acuity. The benefit was maintained 5 months after eplerenone withdrawal. Our results identify MR signaling as a pathway controlling choroidal vascular bed relaxation and provide a pathogenic link with human CSCR, which suggests that blockade of MR could be used therapeutically to reverse choroid vasculopathy.
Assisted Perception, Planning and Control for Remote Mobility and Dexterous Manipulation (2017)

Abstract : This report describes the methods, procedures and results of developing software infrastructure for allowing remote control of a bipedal human-scale Atlas robot. This work focuses on allowing remote operations in severely communications restricted environments for search and rescue. The research relied heavily on abstraction methods for issuing commands, compression and processing of sensor data, and ensuring the safety of the robot during execution. The DARPA Robotics Challenge provided a live demonstration to showcase the robots performance in a simulated search and rescue environment. The abstraction techniques developed from both a control and terrain estimation viewpoint, were successfully able to allow autonomous operation. These techniques substantially reduced the amount of communication necessary between the human operator and the robot allowing them to operate with substantial delays in communication as well as complete losses of communication. The software developed was successfully able to control the robot to complete a significant majority of tasks to drive a vehicle, dismount the vehicle, open a door, manipulate various objects and ultimately walk through uneven surfaces and climb stairs. MIT placed sixth in the finals which was an impressive finish given that their best run required them to operate without the use of one arm which was damaged in a fall.
Effect of Tibial Plateau Leveling on Cranial and Caudal Tibial Thrusts in Canine Cranial Cruciate–Deficient Stifles: An In Vitro Experimental Study (2001)

This study suggests that, during stance phase, TPL transforms cranial tibial thrust into caudal tibial thrust, thereby stabilizing the stifle in the cranio-caudal plane via the constraint of the CaCL. The increase in CaCL stress, which results from tibial plateau rotation, could predispose the CaCL to fatigue failure and therefore would caution against tibial plateau over-rotation.
Identification of Type IV Collagenase in Rat Testicular Cell Culture: Influence of Peritubular-Sertoli Cell Interactions1 (1990)

In the testis, interactions between peritubular cells (mesenchyme) and Sertoli cells (epithelium), together with proteolytic remodeling of the extracellular matrix, may play a central role in testicular development, morphogenesis, and spermatogenesis. In this study we demonstrate that a metalloproteinase of 72 kDa present in rat Sertoli cell and Sertoli-peritubular cell coculture medium is activated by p-aminophenylmercuric acetate (p-APMA) to a lower molecular mass form, indicating that it is likely to be a latent collagenase. Immunoblots using antibodies to three different domains of type IV collagenase show that the 72-kDa protease and a 76-kDa protease are type IV pro-collagenases. Sertoli cells cultured alone produce basal levels of type IV collagenase that can be immunolocalized in the cytoplasm of cultured cells. Peritubular cells cultured alone produce much less type IV collagenase. However, Sertoli and peritubular cells in coculture do produce type IV pro-collagenase, and in cultures consisting predominantly of peritubular cells, the activated form of type IV collagenase was detected by both zymography and immunoblotting. Cells growing during the transitional phase (from cell attachment to confluence) secrete more metalloproteinases than during the confluent phase. In contrast, plasminogen activator levels are unaffected by time in culture. These results show that rat testicular cells in culture produce and secrete type IV collagenase, and that the secretion and activation of this enzyme and other metalloproteases is regulated by the ratio of mesenchymal cells to epithelial cells and time in culture.
Abstract 3573: Identification and functional characterization of prognostic long non coding RNA LADDER in lung cancer (2019)

Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths in the world. Disease subtypes include lung adenocarcinoma (LUAD), which accounts for nearly 50% of lung malignancies, and lung squamous carcinoma (LUSC). Disease diagnosis at late stages and limited therapeutic options are the major causes for the poor prognosis of lung cancer patients. Additionally, lack of discriminatory diagnostic and prognostic biomarkers have hampered therapeutic management and, consequently, NSCLC patients are treated as one entity. In this modern era, the development of next generation based RNA sequencing (RNA-Seq) methodologies enable us to accurately quantify the transcriptional abundance in cells in a highly reproducible and reliable manner. By utilizing this technology, we sequenced a large cohort of lung cancer samples and leveraged several publically available RNA-Seq datasets for analysis to facilitate a deeper understanding of the disease. Furthermore, from the large RNA-Seq datasets, we also discovered long noncoding RNAs (lncRNA). These transcripts, which are longer than 200 nucleotides that are not translated into protein, have tissue-, lineage-, and cancer-specific expression patterns. In our previous study, we developed a highly significant prognostic marker gene signature by analyzing 255 LUAD patients from The Cancer Genome Atlas (TCGA) dataset. Using a training cohort, 96 genes including 5 lncRNAs had significant prognostic associations with lung cancer. Further, a stepwise regression model identified a four-gene signature, including one lncRNA (LADDER). The four-gene signature was then validated in two independent patient cohorts from the TCGA and in-house data. Functional studies showed that inhibition of LADDER lncRNA using both siRNA and ASOs decreased cell proliferation in lung cancer cells. In addition, knockdown of LADDER lncRNA using ASOs decreased lung cancer cell growth in vivo. Taken together, we have identified the lncRNA LADDER, a member of a four-gene prognostic signature, to play a functional role in lung cancer progression as well as serve as a robust prognostic marker.Note: This abstract was not presented at the meeting.Citation Format: Sathiya Pandi Narayanan, Sudhanshu Shukla, Jean Tien, Palak Shah, Sunita Shankar, Sethuramasundaram Pitchaiya, Srihari Srinivasan, Yuping Zhang, Xiaoming Wang, Lanbo Xiao, Xuhong Cao, Susan Freier, Andrew Watt, Shuling Guo, Felix Feng, David Beer, Saravana M. Dhanasekaran, Arul M. Chinnaiyan. Identification and functional characterization of prognostic long non coding RNA LADDER in lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3573.