gebhart/patrepeval huggingface dataset:
ChemInform Abstract: The 1,3‐Migration of Phosphorus from Oxygen to Carbon: A New Synthesis of β‐Ketophosphonates from Enol Phosphates. (1987)

Abstract Camphor (I) reacts with LDA and diethyl chlorophosphate (II) to give the enol phosphate (III) which rearranges to form the camphor phosphonate (IV).
Study of the electronic structure and spectra of diphenylcarbene conformers in their ground state and lower excited states (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudy of the electronic structure and spectra of diphenylcarbene conformers in their ground state and lower excited statesA. Despres, V. Lejeune, E. Migirdicyan, A. Admasu, M. S. Platz, G. Berthier, O. Parisel, J. P. Flament, I. Baraldi, and F. MomicchioliCite this: J. Phys. Chem. 1993, 97, 50, 13358–13367Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/j100152a048https://doi.org/10.1021/j100152a048research-articleACS PublicationsRequest reuse permissionsArticle Views97Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A graphene-based transparent electrode for use in flexible optoelectronic devices (2014)

Graphene, a monolayer of carbon atoms arranged in a honeycomb structure, is a unique material with outstanding properties that may be useful in applications ranging from electronic devices to energy storage devices.
Control of Acetic Acid Fermentation by Quorum Sensing via N -Acylhomoserine Lactones in Gluconacetobacter intermedius (2008)

A number of gram-negative bacteria regulate gene expression in a cell density-dependent manner by quorum sensing via N-acylhomoserine lactones (AHLs). Gluconacetobacter intermedius NCI1051, a gram-negative acetic acid bacterium, produces three different AHLs, N-decanoyl-l-homoserine lactone, N-dodecanoyl-L-homoserine lactone, and an N-dodecanoyl-L-homoserine lactone with a single unsaturated bond in its acyl chain, as determined by liquid chromatography-tandem mass spectrometry. Two genes encoding an AHL synthase and a cognate regulator were cloned from strain NCI1051 and designated ginI and ginR, respectively. Disruption of ginI or ginR abolished AHL production, indicating that NCI1051 contains a single set of quorum-sensing genes. Transcriptional analysis showed that ginI is activated by GinR, which is consistent with the finding that there is an inverted repeat whose nucleotide sequence is similar to the sequence bound by members of the LuxR family at position -45 with respect to the transcriptional start site of ginI. A single gene, designated ginA, located just downstream of ginI is transcribed by read-through from the GinR-inducible ginI promoter. A ginA mutant, as well as the ginI and ginR mutants, grew more rapidly in medium containing 2% (vol/vol) ethanol and accumulated acetic acid at a higher rate with a greater final yield than parental strain NCI1051. In addition, these mutants produced larger amounts of gluconic acid than the parental strain. These data demonstrate that the GinI/GinR quorum-sensing system in G. intermedius controls the expression of ginA, which in turn represses oxidative fermentation, including acetic acid and gluconic acid fermentation.
Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccines in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Immunogenicity and Reactogenicity (2021)

The severe acute respiratory syndrome coronavirus 2 messenger RNA vaccine-induced humoral response and reactogenicity profile are described in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Findings showed that 75.0% (by Simoa assay) or 80.0% (by Roche assay) of the HSCT cohort had a positive antibody response on series completion, compared with 100% in the healthy cohort.
Immunization with vaccinia virus recombinants that express the surface glycoproteins of human parainfluenza virus type 3 (PIV3) protects patas monkeys against PIV3 infection (1988)

Patas monkeys (Eryphrocebus patas) were immunized intradermally with two vaccinia virus recombinants that individually express the hemagglutinin-neuraminidase glycoprotein or the fusion glycoprotein of human parainfluenza virus type 3 (PIV3). These immunizations induced a high titer of PIV3 serum-neutralizing antibodies. At 1 month after immunization, monkeys were challenged intratracheally with PIV3. Subsequent virus replication was reduced in these monkeys by 3.2 log10 and 1.9 log10 (mean peak virus titers) in the upper and lower respiratory tracts, respectively, compared with control animals. The average duration of virus shedding was also reduced from 9.0 to 3.4 days in the upper respiratory tract and from 5.3 to 1.2 days in the lower respiratory tract. These findings demonstrate that a single intradermal dose of live recombinant vaccinia viruses can significantly restrict the replication of a virus which primarily infects the epithelial cells of the respiratory tract.
Webwise (2005)

Hypertension is everywhere out there on the internet. A Google search brings up 7,720,000 blood pressure-related websites for your perusal.
Experimental Study of kW-class Wireless Charging System for Autonomous Underwater Vehicle with Magnetic Resonance (2023)

A magnetic field resonant wireless power charging system for AUVs was constructed using multiple coils. The charging system, which consists of a charging control circuit, a lithium-ion battery, and an AUV device, was built in the second stage of the rectifier circuit. Using a prototype power receiving coil and charging control circuit, which was installed in the AUV, charge, and discharge experiments were conducted in an actual sea environment. When the receiving coil was in the center of the transmission coil, the transmission efficiency was 71%, and 3 kW of charging was confirmed. Charging operation was also possible during thruster operation, which makes over 10A currents consumption drifts in AUV. It indicates the high robustness of the charging system.
Theoretical Investigation of Excitation Energy Transfer Mechanism in Porphyrin Dimeric Array (2006)

We investigated the excitation energy transfer in a diphenylethyne-linked porphyrin dimeric array in which zinc porphyrin (ZnP) is linked to free-base porphyrin (FbP) by diphenylethyne. By carrying out quantum chemical calculations, we computed the excited-state potential energies for several structures on the reaction path for the ZnP rotation around the axis along a ZnP–diphenylethyne bond. The computations showed that the potential-energy curves of the initial and final electronic states that are formed by the electronic excitation of the ZnP and FbP moieties become close to each other while changing from the stable structure to the transition-state structure. The potential energy change at the initial electronic state from the reactant to the point where the two potential-energy curves are closest was also found to be small. These findings lead to the suggestion that the excitation energy transfer is caused by nonadiabatic interaction induced by the easy rotation of ZnP around the axis along a ZnP–diphenylethyne bond.
Drug Repurposing Identifies Inhibitors of Oseltamivir‐Resistant Influenza Viruses (2016)

Abstract The neuraminidase (NA) inhibitor, oseltamivir, is a widely used anti‐influenza drug. However, oseltamivir‐resistant H1N1 influenza viruses carrying the H275Y NA mutation spontaneously emerged as a result of natural genetic drift and drug treatment. Because H275Y and other potential mutations may generate a future pandemic influenza strain that is oseltamivir‐resistant, alternative therapy options are needed. Herein, we show that a structure‐based computational method can be used to identify existing drugs that inhibit resistant viruses, thereby providing a first line of pharmaceutical defense against this possible scenario. We identified two drugs, nalidixic acid and dorzolamide, that potently inhibit the NA activity of oseltamivir‐resistant H1N1 viruses with the H275Y NA mutation at very low concentrations, but have no effect on wild‐type H1N1 NA even at a much higher concentration, suggesting that the oseltamivir‐resistance mutation itself caused susceptibility to these drugs.
Renal dopamine receptors and pre- and post-cAMP-mediated Na+ transport defect in spontaneously hypertensive rats (1992)

We have reported defective coupling of the renal tubular DA1 dopamine receptor to adenylyl cyclase in both the spontaneously hypertensive rat (SHR) and the Dahl salt-sensitive rat. Since Na+, 5'-guanyl imidodiphosphate [Gpp(NH)p], and N-ethylmaleimide (NEM) reduce agonist affinity for brain D1 dopamine receptors, we compared the effects of these agents on agonist affinity in proximal tubules from SHR and its normotensive control, the Wistar-Kyoto rat (WKY), to delineate further the site of the DA1-adenylyl cyclase coupling defect. In WKY, the D1/DA1 agonist, fenoldopam, competed for 125I-Sch 23982 at a high-affinity site (KiH = 1.8 +/- 0.8 x 10(-8) M) and a low-affinity site (KiL = 7.6 +/- 1.1 x 10(-5) M, n = 6). Na+ (150 mM) or Gpp(NH)p (10(-4) M) converted KiH to KiL. NEM, which alkylates sulfhydryl groups, also converted all the binding to KiL; this effect could be prevented by prior treatment with 10(-4) M fenoldopam. In contrast, in SHR, fenoldopam detected only a KiL (7.8 +/- 1.4 x 10(-5) M, n = 6). Neither Na+, Gpp(NH)p, nor NEM had any effect on KiL. To study a functional expression of these binding sites, the effect of 5 x 10(-5) M fenoldopam or 8-(chlorophenylthio)-adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP) on Na+/H+ exchange activity in proximal tubular brush-border membrane vesicles was tested. In WKY, the inhibitory effects of these agents on the exchanger increased with the age of the rat.(ABSTRACT TRUNCATED AT 250 WORDS)
Simulation of high-pressure micro-capillary3He counters (2008)

Low-pressure (1–4 atm) cylindrical <sup>3</sup>He counters are widely used as neutron detectors. These detectors are relatively large (1–2.5 cm diameter) and can be subject to noise induced by microphonics. Meanwhile, new advancements in micro-fabrication are enabling the manufacture of high-pressure (over 3000 atm) micro-capillaries (~100 µm diameter). Can these micro-capillaries be used as accurate and high-efficiency <sup>3</sup>He counters? To answer these questions, we have developed a mathematical model/computer simulation. Our model shows that such capillaries have the potential for being high-efficiency neutron spectrometers capable of resolving not only energy, but also angle of incidence for fixed sources. Finally, we benchmark the model against published results and extrapolate spectra to the pressures of interest.
Model-assisted coding of video teleconferencing sequences at low bit rates (2002)

We present a novel and practical way to integrate techniques from computer vision to low bit rate coding systems for video teleconferencing applications. Our focus is to locate and track the faces of persons in typical head-and-shoulders video sequences, and to exploit the face location information in a "classical" video coding/decoding system. The motivation is to enable the system to selectively encode various image areas and to produce psychologically pleasing coded images where faces are sharper. We refer to this approach as model-assisted coding. We propose a totally automatic, low-complexity algorithm, which robustly performs face detection and tracking. A priori assumptions regarding sequence content are minimal and the algorithm operates accurately even in cases of occlusion by moving objects. Face location information is exploited by a low bit rate 3D subband-based video coder which uses a model-assisted dynamic bit allocation with object-selective quantization. By transferring a small fraction of the total available bit rate from the non-facial to the facial area, the coder produces images with better-rendered facial features. The improvement was found to be perceptually significant on video sequences coded at 96 kbps for an input luminance signal in CIF format. The technique is applicable to any video coding scheme that allows for fine-grain quantizer selection (e.g. MPEG, H.261), and can maintain full decoder compatibility.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Comparisons of the composition of fat cells obtained from the marrow of normal individuals or of subjects with aplastic anemia and from bone marrow cultures. (1984)

The lipid composition of fat cells in the bone marrow of normal individuals and patients with aplastic anemia was investigated, using thin-layer and gas-liquid chromatography. The results were compared to those obtained from fat cells grown in vitro. Thin-layer chromatography (t.l.c) revealed that triacylglycerols were the major component of normal and aplastic marrow fat cells and of fat cells in culture. Analysis by gas-liquid chromatography (g.l.c) of the triacylglycerols, diacylglycerols, and nonesterified fatty acids detected minor differences between fat cells from normal and aplastic marrow. Although there were no statistically significant differences in the proportions of saturated fatty acids and their unsaturated analogues, the relative amounts of gamma-linolenic acid were increased in aplastic anemia and those of linoleic and myristoleic acids were reduced. In contrast, fat cells obtained from in vitro cultures contained a much higher proportion of unsaturated fatty acids. These findings indicate that there is no marked abnormality in the composition of bone marrow fat cells in aplastic anemia, but that minor differences can be detected; the fatty acid composition of bone marrow fat cells is not reproduced in vitro.
RunWithUs (2011)

Authorities recommend the practice of moderate physical activity to improve health and quality of life, but sometimes it is difficult to find the willpower or the motivation to reserve a few minutes to exercise. In this paper we describe a new tool designed to help users to practice sport and record their achievements, which makes the activity more social (finding friends, sharing results, etc.). Furthermore, this tool has been integrated in the "Ubiquitous Oulu", an intelligent city that provides the building blocks to bring it closer to citizens. In this real-life environment we had the opportunity to assess the technical viability of RunWithUs and to identify the main interests of its potential users.
Study and Sub-System Optimization of Propulsion and Drive Systems for the Large Civil TiltRotor (LCTR2) Rotorcraft (2013)

In a series of study tasks conducted as a part of NASA's Fundamental Aeronautics Program, Rotary Wing Project, Boeing and Rolls-Royce explored propulsion, drive, and rotor system options for the NASA Large Civil Tilt Rotor (LCTR2) concept vehicle. The original objective of this study was to identify engine and drive system configurations to reduce rotor tip speed during cruise conditions and quantify the associated benefits. Previous NASA studies concluded that reducing rotor speed (from 650 fps hover tip speed) during cruise would reduce vehicle gross weight and fuel burn. Initially, rotor cruise speed ratios of 54% of the hover tip speed were of most interest during operation at cruise air speed of 310 ktas. Interim results were previously reported1 for cruise tip speed ratios of 100%, 77%, and 54% of the hover tip speed using engine and/or gearbox features to achieve the reduction. Technology levels from commercial off-the-shelf (COTS), through entry-in-service (EIS) dates of 2025 and 2035 were considered to assess the benefits of advanced technology on vehicle gross weight and fuel burn. This technical paper presents the final study results in terms of vehicle sizing and fuel burn as well as Operational and Support (O&amp;S) costs. New vehicle sizing at rotor tip speed reduced to 65% of hover is presented for engine performance with an EIS 2035 fixed geometry variable speed power turbine. LCTR2 is also evaluated for missions range cases of 400, 600, 800, 1000, and 1200 nautical miles and cruise air speeds of 310, 350 and 375 ktas.
Histopathology of experimental preretinal neovascularization. (1989)

Despite the morbidity resulting from abnormal retinal neovascularization, morphological events associated with its development have not been fully described. We therefore studied sequential morphologic events during preretinal neovascularization in an experimental model induced by injection of 250,000 homologous fibroblasts into the vitreous cavity of rabbits. Within 2 days following fibroblast injection, thickening of many venular and capillary endothelial cells resulted in partial obliteration of their lumina. 3H-thymidine incorporation occurred first in the nonvascular cells of the superficial medullary ray and thereafter in the preretinal vessels and extraretinal fibroblasts. Capillary budding was obvious within 3 days, with endothelial cells extending cytoplasmic processes into fragmented extracellular matrix (ECM). Endothelial cells, at the tips of budding vessels, and at more proximal sites in the parent vessel, incorporated 3H-thymidine and did not lose cell contact or migrate individually into the ECM. Lumina were present throughout the entire length of the buds and endothelial cells remained polarized. Neovascular events observed in this experimental model parallel those previously described in diabetic retinopathy and retinopathy of prematurity in humans.
0.5 nm EOT low leakage ALD SrTiO<inf>3</inf> on TiN MIM capacitors for DRAM applications (2008)

We demonstrate for the first time record low Leakage-EOT (3.5 times 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-7</sup> A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at 1V, EOT=0.49 nm) MIM capacitors fabricated using a low temperature (250degC) ALD SrTiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (STO) deposition process on ALD TiN bottom electrode. While most previous work on STO used deposition techniques not compatible with high aspect ratio DRAM applications, recent work on ALD STO showed promise on noble-like metal electrodes (Ru, Pt) [1,2]. In this work, a low temperature ALD process with alternative precursor set and carefully optimized deposition and processing conditions enables the use of low-cost, manufacturable-friendly TiN electrode MIMcaps for future DRAM nodes. Composition (Sr-rich) and process optimization allowed minimization of interfacial EOT penalties and leakage reduction by decreasing the density of leakier STO grains.
Formation of Covalently Bonded Polycyclic Hydrocarbon Ions by Intracluster Polymerization of Ionized Ethynylbenzene Clusters (2014)

Here we report a detailed study aimed at elucidating the mechanism of intracluster ionic polymerization following the electron impact ionization of van der Waals clusters of ethynylbenzene (C8H6)n generated by a supersonic beam expansion. The structures of the C16H12, C24H18, C32H24, C40H30, and C48H36 radical cations resulting from the intracluster ion-molecule addition reactions have been investigated using a combination of mass-selected ion dissociation and ion mobility measurements coupled with theoretical calculations. Noncovalent structures can be totally excluded primarily because the measured fragmentations cannot result from noncovalent structures, and partially because of the large difference between the measured collision cross sections and the calculated values corresponding to noncovalent ion-neutral complexes. All the mass-selected cluster ions show characteristic fragmentations of covalently bonded molecular ions by the loss of stable neutral fragments such as CH3, C2H, C6H5, and C7H7. The population of the C16H12 dimer ions is dominated by structural isomers of the type (C6H5)-C≡C-CH(•+)CH-(C6H5), which can grow by the sequential addition of ethynylbenzene molecules, in addition to some contributions from cyclic isomers such as the 1,3- or 1,4-diphenyl cyclobutadiene ions. Similarly, two major covalent isomers have been identified for the C24H18 trimer ions: one that has a blocked cyclic structure assigned to 1,2,4- or 1,3,5-triphenylbenzene cation, and a second isomer of the type (C6H5)-C≡C-C(C6H5)═CH-CH(•+)CH-(C6H5) where the covalent addition of further ethynylbenzene molecules can occur. For the larger ions such as C32H24, C40H30, and C48H36, the major isomers present involve the growing oligomer sequence (C6H5)-C≡C-[C(C6H5)═CH]n-CH(•+)CH-(C6H5) with different locations and orientations of the phenyl groups along the chain. In addition, the larger ions contain another family of structures consisting of neutral ethynylbenzene molecules associated with the blocked cyclic isomer ions such as the diphenylcyclobutadiene and triphenylbenzene cations. Low-energy dissociation channels corresponding to evaporation of ethynylbenzene molecules weakly associated with the covalent ions are observed in the large clusters in addition to the high-energy channels corresponding to fragmentation of the covalently bonded ions. However, in small clusters only high-energy dissociation channels are observed corresponding to the characteristic fragmentation of the molecular ions, thus providing structural signatures to identify the product ions and establish the mechanism of intracluster ionic polymerization.
Applications of Next-Generation Sequencing in Neoantigen Prediction and Cancer Vaccine Development (2019)

Next-generation sequencing has changed the face of cancer immunotherapy research by making tumor-specific cancer vaccines a reality. Whole exome sequencing and RNA sequencing combined with bioinformatic pipelines allow the prediction of neoantigen targets for cancer vaccines. In this review, we discuss the preclinical and early clinical evidence for cancer vaccines; describe methods and challenges in neoantigen prediction; and summarize emerging new technologies that will improve neoantigen cancer vaccine development.