gebhart/patrepeval huggingface dataset:
5G-MiEdge: Design, standardization and deployment of 5G phase II technologies: MEC and mmWaves joint development for Tokyo 2020 Olympic games (2017)

This paper presents the vision of 5G-MiEdge, a research project leveraging the benefits of merging MEC and mmWave technologies. Based on that vision, the most relevant use cases and services for the forthcoming Tokyo 2020 Olympics are proposed. The focus is on showing how integrating MEC and mmWave into the 5G network architecture can offer a much more effective system. That is achieved by means of an edge cloud and the introduction of an ultra-lean and inter-operable signaling, called `liquid control plane', capable of providing ubiquitous allocation of computation and communication resources, in an application-/user-centric framework. Finally standards-related aspects like the 5G-MiEdge impact on the ongoing 3GPP work and the services that compose the 5G phases are discussed.
Development of vertical and tapered via etch for 3D through wafer interconnect technology (2006)

Two types of dry silicon etch techniques are developed to cover two different areas of demand for interconnect technology: one for high aspect ratio (AR) vertical vias and one for tapered vias. Various sizes of vertical vias and trenches with diameters/widths ranging from 1-100 mum with an AR up to 50 are realized using Bosch deep reactive ion etch (DRIE) process. A linear model is applied to describe and to give physical insight in the aspect ratio dependant etch (ARDE) effect. The feasibility of the vertical vias as electrical interconnect is shown by isolating them from the substrate by silicon oxide and then filling with polysilicon. The tapered vias are typically post-processed on fabricated device wafers, making it inherently a more generic approach where diameter size can be large and low AR can be tolerated. Vias with a depth of ~100 mum and a diameter of ~50mum at the bottom (though larger at top) are realized. Varying various etch parameters, slope angles of 70deg-80deg are realized to allow for conformal deposition of dielectric/seed materials on the sidewalls and to allow lithography within the via. Reactive ion etch (RIE) is used to fabricate sloped vias by simultaneously applying etch and passivation gasses. Negative angles on the via top and sidewall roughness are observed that introduce conformal coating problems and increased leakage currents. Smoothening techniques using maskless wet and dry silicon etching are investigated to overcome these problems.
Molecular Dynamics simulations of magnetron (reactive) sputtering and deposition (2014)

International audience
Functional genomic approaches in cereal rusts (2012)

Abstract Cereal rust fungi are pathogens of major importance to agriculture, threatening cereal production worldwide. Targeted breeding for resistance, based on information from fungal surveys and population structure analyses of virulence, has been effective. Nevertheless, breakdown of resistance occurs frequently and continued efforts are needed to understand how these fungi overcome resistance and to determine the range of available resistance genes. The development of genomic resources for these fungi and their comparison has released a torrent of new ideas and approaches to use this information to assist pathologists and agriculture in general. The sequencing of gene transcripts and the analysis of proteins from haustoria has yielded candidate virulence factors among which could be defence-triggering avirulence genes. Genome-wide computational analyses, including genetic mapping and transcript analyses by RNA sequencing of many fungal isolates, will predict many more candidates. Functional assays, such as leaf infiltration using Agrobacterium for delivery of cloned fungal effectors, are being developed. This will allow the screening of wheat germplasm for novel resistance genes for breeding. Comparative analyses have also revealed fungal virulence genes, providing fungal targets for disease control in host-produced RNAi approaches.
The Small RNAs PA2952.1 and PrrH as Regulators of Virulence, Motility, and Iron Metabolism in Pseudomonas aeruginosa (2020)

<i>Pseudomonas aeruginosa</i> is a Gram-negative opportunistic pathogen that undergoes swarming motility in response to semisolid conditions with amino acids as a nitrogen source. With a genome encoding hundreds of potential intergenic small RNAs (sRNAs), <i>P. aeruginosa</i> can easily adapt to different conditions and stresses. We previously identified 20 sRNAs that were differentially expressed (DE) under swarming conditions. Here, these sRNAs were overexpressed in strain PAO1 and were subjected to an array of phenotypic screens. Overexpression of the PrrH sRNA resulted in decreased swimming motility, whereas a Δ<i>prrH</i> mutant had decreased cytotoxicity and increased pyoverdine production. Overexpression of the previously uncharacterized PA2952.1 sRNA resulted in decreased swarming and swimming motilities, increased gentamicin and tobramycin resistance under swarming conditions, and increased trimethoprim susceptibility. Transcriptome sequencing (RNA-Seq) and proteomic analysis were performed on the wild type (WT) overexpressing PA2952.1 compared to the empty vector control under swarming conditions, and these revealed the differential expression (absolute fold change [FC] ≥ 1.5) of 784 genes and the differential abundance (absolute FC ≥ 1.25) of 59 proteins. Among these were found 73 transcriptional regulators, two-component systems, and sigma and anti-sigma factors. Downstream effectors included downregulated pilus and flagellar genes, the upregulated efflux pump MexGHI-OpmD, and the upregulated <i>arn</i> operon. Genes involved in iron and zinc uptake were generally upregulated, and certain pyoverdine genes were upregulated. Overall, the sRNAs PA2952.1 and PrrH appeared to be involved in regulating virulence-related programs in <i>P. aeruginosa</i>, including iron acquisition and motility.<b>IMPORTANCE</b> Due to the rising incidence of multidrug-resistant (MDR) strains and the difficulty of eliminating <i>P. aeruginosa</i> infections, it is important to understand the regulatory mechanisms that allow this bacterium to adapt to and thrive under a variety of conditions. Small RNAs (sRNAs) are one regulatory mechanism that allows bacteria to change the amount of protein synthesized. In this study, we overexpressed 20 different sRNAs in order to investigate how this might affect different bacterial behaviors. We found that one of the sRNAs, PrrH, played a role in swimming motility and virulence phenotypes, indicating a potentially important role in clinical infections. Another sRNA, PA2952.1, affected other clinically relevant phenotypes, including motility and antibiotic resistance. RNA-Seq and proteomics of the strain overexpressing PA2952.1 revealed the differential expression of 784 genes and 59 proteins, with a total of 73 regulatory factors. This substantial dysregulation indicates an important role for the sRNA PA2952.1.
Immunoglobulin Light Chain (2020)

A protein complex that consists of two light chains (kappa and lambda). The light chain molecules are of the same structure and composition, consisting of constant, variable, and hypervariable regions.
Author response: Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila (2018)

Parkinson’s disease is a brain disorder where certain nerve cells slowly die, and the symptoms gradually worsen over time. While the risk of developing the condition increases with age, in certain patients the illness is caused by defects in two proteins, PINK1 and parkin. PINK1 and parkin help to manage mitochondria, the compartments in our cells that create molecules that serve as the energy currency for nearly all biological processes. When mitochondria get damaged, they release harmful substances that can kill their host cell. To prevent this, PINK1 and parkin can start a process known as mitophagy, which allows the cell to safely dispose of these dangerous mitochondria. Yet, mitophagy that is triggered by PINK1 and parkin has only been observed in cells grown in the laboratory; there is very little direct evidence that it also takes place in living organisms. If this mechanism does not happen in animals, then it is probably not relevant to Parkinson’s disease. Here, Cornelissen et al. genetically engineered fruit flies that carry a fluorescent marker which helps to track when and where damaged mitochondria are destroyed by a cell. The experiments revealed that mitophagy took place in muscles and in brain tissues. As the animals grew older, mitophagy became more frequent. However, this increase in mitophagy was not seen in insects that did not have PINK1 and parkin. These results showed that the role of PINK1 and parkin in mitophagy is not restricted to cells grown artificially. The fruit flies designed by Cornelissen et al. will be useful to investigate how PINK1 and parkin keep cells healthy by disposing of harmful mitochondria in living organisms. Ultimately, this may help to develop treatments that slow down the development of Parkinson’s disease.
Undermodeling affects minimal model indexes: insights from a two-compartment model (1999)

The classic (hereafter cold) and the labeled (hereafter hot) minimal models are powerful tools to investigate glucose metabolism. The cold model provides, from intravenous glucose tolerance test (IVGTT) data, indexes of glucose effectiveness (SG) and insulin sensitivity (SI) that measure the effect of glucose and insulin, respectively, to enhance glucose disappearance and inhibit endogenous glucose production. The hot model provides, from hot IVGTT data, indexes of glucose effectiveness (SG*) and insulin sensitivity (SI*) that, respectively, measure the effects of glucose and insulin on glucose disappearance only. Recent reports call for a reexamination of some of the assumptions of the minimal models. We have previously pointed out the criticality of the single-compartment description of glucose kinetics on which both the minimal models are founded. In this paper we evaluate the impact of single-compartment undermodeling on SG, SI*, and by using a two-compartment model to describe the glucose system. The relationships of the minimal model indexes to the analogous indexes measured with the glucose clamp technique are also examined. Theoretical analysis and simulation studies indicate that cold indexes are more affected than hot indexes by undermodeling. In particular, care must be exercised in the physiological interpretation of SG, because this index is a local descriptor of events taking place in the initial portion of the IVGTT. As a consequence, SG not only reflects glucose effect on glucose uptake and production but also the rapid exchange of glucose between the accessible and nonaccessible glucose pools that occurs in the early part of the test.
SERUM LEVELS AND RECEPTOR EXPRESSION OF TUMOR NECROSIS FACTOR-α FOLLOWING HUMAN ALLOGENEIC AND AUTOLOGOUS BONE MARROW TRANSPLANTATION (1992)

We have investigated tumor necrosis factor-alpha levels in serum samples of patients before and after allogenic (16 patients) or autologous (8 patients) bone marrow transplantation. A sensitive immunoradiometric assay for monitoring levels of endogenous tumor necrosis factor-alpha was used. The serum levels of tumor necrosis factor-alpha were found to be relatively low (ranging from less than 15 to 77 pg/ml). Among 13 patients having graft-versus-host disease following allogeneic bone marrow transplantation 8 patients did not have detectable tumor necrosis factor-alpha (less than 15 pg/ml) while 4 out of 8 patients undergoing autologous bone marrow transplantation had detectable tumor necrosis factor-alpha levels (15 pg/ml), indicating a lack of correlation between tumor necrosis factor-alpha serum levels and the occurrence of graft-versus-host disease. Because the tumor necrosis factor-alpha levels detected in patient sera could be regulated by TNF-receptor expression, the presence of TNF-receptor on patients' peripheral blood mononuclear cells was also studied using fluorescent liposome-conjugated tumor necrosis factor-alpha and immunofluorescence analysis. Our data indicate that peripheral blood mononuclear cells of some patients receiving either autologous or allogeneic bone marrow transplantation expressed significant levels of TNF-receptors, suggesting a lack of correlation between TNF-receptor expression and graft-versus-host disease development.
Context-sensitive resource discovery (2004)

This paper presents the "Solar" system framework that allows resources to advertise context-sensitive names and for applications to make context-sensitive name queries. The heart of our framework is a small specification language that allows composition of "context-processing operators" to calculate the desired context. Resources use the framework to register names, and applications use the framework to look up context-sensitive name descriptions. The back-end system executes these operators and constantly updates the context values, adjusting advertised names and informing applications about changes. We report experimental results from a prototype, using a modified version of the intentional naming system (INS) as the core directory service.
Antithrombotic therapy in patients with non-traumatic intracerebral haemorrhage and atrial fibrillation: A retrospective study (2020)

Treating patients with intracerebral haemorrhage and atrial fibrillation is challenging due to higher mortality rates and issues regarding the use of antithrombotic treatment in stroke prevention. Based on our data, prior antithrombotic therapy was not associated with increased in-hospital mortality rates or poorer functional outcome at hospital discharge in comparison with no prior antithrombotic therapy.
EMS: Efficient Multicast Streaming Scheme for Multicasting within Wi-Fi Hotspot (2015)

We have discovered two main problems when a multicast sender and multicast receivers are associated with the same AP. First, the multicast sender cannot determine a proper sending rate with the traditional end-to-end rate-adaptation schemes. Second, the multicast sender wastes its power due to the unique characteristics of power saving mode of the IEEE 802.11 standard. We propose efficient multicast streaming (EMS) to solve these problems without modifying the AP and the multicast receivers. With EMS, the multicast sender adapts its sending rate at the application layer and adjusts the sleep cycle at the MAC layer by monitoring multicast packets sent from the AP. Our experimentation and simulation results show that EMS can improve video quality at the receivers and reduce power consumption of the multicast sender significantly.
ChemInform Abstract: A Palladium‐Catalyzed Strategy for the Preparation of Indoles: A Novel Entry into the Fischer Indole Synthesis. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
PIC-MCC Simulations of Capacitive RF Discharges for Plasma Etching (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Yoshinori Takao, Kenji Matsuoka, Koji Eriguchi, Kouichi Ono; PIC‐MCC Simulations of Capacitive RF Discharges for Plasma Etching. AIP Conf. Proc. 20 May 2011; 1333 (1): 1051–1056. https://doi.org/10.1063/1.3562784 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Urachal Anomalies in Children: A Proper Approach and Treatment Based on the Recent Ten-year Experience (2006)

Purpose: To establish the proper approach and management of an urachal anomaly in children. Materials and Methods: We retrospectively reviewed the medical records and imaging studies of 33 children (21 boys, 12 girls) treated for an urachal anomaly over a ten-year period. Results: Twenty-four patients were equally diagnosed with either an urachal sinus or urachal cyst; the other nine patients were confirmed to have a patent urachus. Umbilical discharge (14 patients) and umbilical granuloma (9 patients) were the most common presentations. The 12 patients with an urachal sinus underwent ultrasonography (USG) (10; diagnostic), 2 fistulography (all; diagnostic). Those with an urachal cyst underwent either USG (6/12; diagnostic), computed tomography (CT) (3; diagnostic), fistulography (2; diagnostic), or magnetic resonance imaging (MRI) (1; diagnostic). One subject was affected by acute appendicitis, which was confirmed by CT. Of the 9 children with patent urachus, 7 underwent USG (all; diagnostic); exploration without further imaging studies was performed on the remaining 2 subjects. Surgical excision was performed in 30 patients. Omphalomesenteric duct or Meckel's diverticulum were incidental findings, which were simultaneously repaired. Conservative treatment was successful in only 3 patients. Conclusions: Urachal anomalies in children mainly manifest as umbilical discharges and umbilical granuloma, but may present non-specific symptoms in some cases. USG is a useful method for diagnosis, but other imaging modalities can be useful to establish the differential diagnosis. A limited number of children with urachal anomalies, mainly presenting with an umbilical discharge, can be managed conservatively. However, complete surgical excision of the lesion, with the possible associated anomalies, should be the basic scheme for children with urachal anomalies. (Korean J Urol 2006;47:651-655)
Sum Rate Optimization by Spatial Precoding for a Multiuser MIMO DFT-Precoded OFDM Uplink (2011)

By means of DFT-precoding, the PAPR of OFDM waveforms can be reduced. DFT-precoding has been proposed for uplink transmission in various future wireless communication systems. In this work, we consider DFT-precoding combined with spatial precoding for the uplink of multiuser MIMO OFDM systems. An efficient algorithm is developed to optimize the spatial precoder aiming at maximization of the system sum rate subject to individual power constraints of the users and maintenance of the low PAPR property for one user. Potential gains are shown compared to other popular precoding methods in 3GPP-LTE uplink scenarios.
Design considerations for soft embedded programmable logic cores (2005)

As integrated circuits become increasingly more complex and expensive, the ability to make post-fabrication changes will become much more attractive. This ability can be realized using programmable logic cores. Currently, such cores are available from vendors in the form of "hard" rectangular layouts. We focus on an alternative approach for fine-grain programmability: vendors supply a synthesized RTL version of their programmable logic core (a "soft" core) and the integrated circuit designer synthesizes the programmable logic fabric using standard cells. Although this technique suffers in terms of speed, density, and power overhead, the task of integrating such cores is far easier than the task of integrating "hard" cores into an ASIC or SoC. When the required amount of programmable logic is small, this ease of use may be more important than the increased overhead. This paper presents two synthesized "soft" programmable logic core architectures and describes their associated place and route issues. We compare the two architectures to each other, and to a "hard" programmable logic core. We also show how these cores can be made more efficient by creating a nonrectangular architecture, an option not usually available to "hard" core vendors. Finally, a proof-of-concept integrated circuit containing one of these cores is described.
Contrast enhanced ultrasound tomography by means of the cumulative phase delay between second harmonic and fundamental component (2015)

Standard dynamic contrast-enhanced ultrasound (DCE-US) imaging detects and estimates ultrasound-contrastagent (UCA) concentration based on the amplitude of the harmonic components generated during ultrasound (US) propagation through UCAs. However, harmonic generation is not specific to UCAs, as it also occurs for US propagating through tissue. Moreover, nonlinear artifacts affect standard DCE-US imaging, causing contrast to tissue ratio (CTR) reduction, and resulting in possible tissue misclassification and misinterpretation of UCA concentrations. Especially for US tomography, no contrast-specific modality exists. Recently, a new marker for UCAs was discovered. A cumulative phase delay (CPD) between the second harmonic (2H) and fundamental (F0) component is in fact observable for US propagating through UCAs, and is absent in tissue. In this paper, CPD based tomographic US images are presented and compared to standard US tomography. By testing its applicability on gelatin phantoms with cylindrical cavities filled with a SonoVue <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> UCA dilution, we showed that CPD tomography outperforms standard US tomography by speed of sound and dispersion analysis, yielding a superior CTR: 32.2 dB vs. 0.06 and 4.6 dB, respectively.
Physical model and characteristics of quantum dot infrared photodetectors (2002)

We develop a physical model for quantum dot infrared photodetectors (QDIPs). Using this model, we calculate the dark current and photocurrent in QDIPs as functions of the QDIP structural parameters and the applied voltage. The obtained results clarify some interesting features of the QDIP characteristics observed experimentally, in particular, a rather steep (exponential) rise of the dark current and photocurrent with increasing applied voltage and the occurrence of negative differential photoconductivity.
Banc de test de capteurs de gaz innovants au LAAS (2014)

National audience
Comparative evaluation of a Triangular Current Mode (TCM) and Clamp-Switch TCM DC-DC boost converter (2016)

For the power management of a wireless power transfer system for implantable mechanical heart pumps, an additional boost DC-DC converter stage is needed in order to control the power delivered to the implant. Particularly, battery powered and implantable medical devices pose special demands on the efficiency and/or power density of the employed converters. Accordingly, soft-switching and/or high switching frequencies must be targeted. Modulation schemes that allow for Zero-Voltage-Switching (ZVS) such as Triangular Current Mode (TCM) offer a highly efficient operation, but suffer from a large operating frequency variation, which is mainly limited by the digital control. Therefore the Clamp-Switch TCM (CL-TCM) converter can be employed which allows also for the control of the switching frequency variation. In this paper, the CL-TCM and the TCM converter are compared regarding the power conversion efficiency and the power density of the converter. Since the CL-TCM converter is not well known in the literature, the converter is analysed in detail and a modulation scheme is explained that allows for ZVS for all switches in the entire range of operation. In addition, the requirements for ZVS and a control scheme (i.e. timing calculations) are provided for the converter in order to limit the maximum switching frequency. The modulation and control scheme are verified with a hardware prototype. Finally, the performance of the CL-TCM converter is measured and compared to the performance of the converter operated in TCM mode. The measurements show that the CL-TCM converter offers similar performance compared to the TCM operation at lower inductor power density, but has the advantage of a significantly reduced switching frequency variation. In applications, where a very high power density is needed, the TCM converter outperforms the CL-TCM converter in terms of efficiency.