gebhart/patrepeval huggingface dataset:
A programmable analogue CMOS chip for high speed image processing based on cellular neural networks (2002)

This paper describes an analogue CMOS VLSI chip which implements a 4/spl times/4 continuous time cellular neural network (CNN) with programmable templates. With a new programmable current mirror circuit, the individual template values can be continuously set between 4 and 1/4 and the sign can be switched. Measurements are presented for the operation of the chip as a connected component detector, holefiller and shadow maker. It is demonstrated that this chip can be considered as an analogue programmable image processor. The programmable templates are to CNNs what instructions are to a microprocessor.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Optimal Content Retrieval Latency for Chunk Based Cooperative Content Replication in Delay Tolerant Networks (2013)

Modern content distribution networks face an increasing multitude of content generators. In order to reach the minimal content retrieval latency in the content distribution networks, content shall be disseminated towards consumers based on its popularity taken from the content distribution networks. This, Combined with dividing media into chunks (heterogeneous valuation of information) and contact duration of the consumers with the access points in delay tolerant networks led us to a novel system for content management in large scale distributed systems. In order to determine where to replicate content we formulated the problem as an integer programming problem. The cost function of this minimization problem is the accumulated weighted communication delay among the content replication servers and also the main content server. Various practical constraints such as limited total budget for content replication in each service provider, limited storage size and downlink bandwidth of the content replication servers are considered. A centralized solution to the problem is derived which gives the performance bound for any decentralized content replication strategy for the presented scenarios.
Catheter ablation for patients with ventricular fibrillation (2008)

Catheter ablation targeting ventricular ectopics and Purkinje potentials is a successful treatment for ventricular fibrillation. Although the long-term results of such procedures are awaited, the short-term results are very encouraging.
Modulation transfer function system for testing telescopic and telemicroscopic low-vision aids (1985)

As part of a study of the relationship between the optical quality of low-vision aids and the quality of vision provided by these devices we wanted to measure their modulation transfer functions (MTF). We present our apparatus for measuring the MTF of low-power telescopes and telemicroscopes (instruments that are nominally afocal in image space). We can test at spatial frequencies up to 100 cycles/deg in object space. MTF tests may be made across the field of vision, through focus, at 0°, 45°, 90°, and 135° scan azimuths, with white light or passband filters, and with artificial pupils. A computerized data acquisition and analysis system corrects digital data for noise, and computes and plots the MTF curves. MTFs of some commonly prescribed telescopic aids are shown and compared.
Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease. (1993)

We compared blast cells from adult and pediatric patients with untreated acute lymphoblastic leukemia (ALL) (as separated groups of T-lineage cell and B-lineage cell ALL) to determine if methotrexate (MTX) polyglutamate formation in adult patients might be a contributing cause to the known difference in clinical outcome, since MTX is a key drug in chemotherapy regimens. Adult B-lineage cell ALL blasts and blasts from the patients with T-lineage cell ALL accumulated lower amounts of total MTX and polyglutamates, especially long-chain MTX polyglutamates (glu3-6) than pediatric B-lineage cell ALL blasts. In view of the importance of polyglutamylation of MTX as a determinant of cytotoxicity of this drug, decreased formation of MTX polyglutamates is likely a contributing cause to the lower cure rate in adult ALL and T-lineage cell ALL as compared to childhood B-lineage cell ALL.
Estrogen receptor‐β in mitochondria: implications for mitochondrial bioenergetics and tumorigenesis (2015)

Estrogen enhances mitochondrial function by enhancing mitochondrial biogenesis and sustaining mitochondrial energy-transducing capacity. Shifts in mitochondrial bioenergetic pathways from oxidative phosphorylation to glycolysis have been hypothesized to be involved in estrogen-induced tumorigenesis. Studies have shown that mitochondria are an important target of estrogen. Estrogen receptor-β (ERβ) has been shown to localize to mitochondria in a ligand-dependent or -independent manner and can affect mitochondrial bioenergetics and anti-apoptotic signaling. However, the functional role of mitochondrial ERβ in tumorigenesis remains unclear. Clinical studies of ERβ-related tumorigenesis have shown that ERβ stimulates mitochondrial metabolism to meet the high energy demands of processes such as cell proliferation, cell survival, and transformation. Thus, in elucidating the precise role of mitochondrial ERβ in cell transformation and tumorigenesis, it will be particularly valuable to explore new approaches for the development of medical treatments targeting mitochondrial ERβ-mediated mitochondrial function and preventing apoptosis.
Beyond Food Security: Challenges in Food Safety Policies Based on International Certifications along a Heterogeneous Food Chain. Its Effects in Mexican&acute;s Health and Poverty (2018)

Taking four of the United Nations Development Goals as reference, this overview describes the need to see from a systemic perspective, the food certifications programs along the food chain in Mexico as today food certifications are voluntary. Using secondary data, the main objectives were: a) there is a fall short in food safety policies and those federal agencies responsible for food safety, to guarantee safe food along the whole domestic food chain, especially in that for low income players; b) the amount of the Mexican Federal Budget Expenses devoted to safety food issues is really low, considering the health, well- being, and food security consequences; and c) due the structural heterogeneity of the Mexican food market, there is a lack of coordination in food regulations along all agents of the food supply chain, bringing to alternate informal markets that put at risk peoples&amp;acute; health, increasing poverty and inequalities. According to this exercise, only 0.7- 8.7% of producers, 12.5% of supermarkets as well as 42.8% of restaurants would have some type of certifications. Public policies must attend this issue in order to improve food safety and security for the whole population, reducing inequalities, poverty and ensuring them a healthy live.
Randomized controlled trial of computer-based treatment of social cognition in schizophrenia: the TRuSST trial protocol (2015)

ClinicalTrials.gov NCT02246426 Registered 16 September 2014.
Certification for Biobanks: The Program Developed by the Canadian Tumour Repository Network (CTRNet) (2012)

Two core aspects of the discipline of biobanking are biospecimen quality and good governance. Meeting the demands of both sample quality and governance can be challenging, especially in a resource limited environment. Frequently, differences between biobank processes reduce the ability for cooperative action and specimen sharing with researchers. In the Canadian context, we have made an attempt to identify these gaps and have provided a framework to support excellence, initially for tumor biobanks. The Canadian Tumour Repository Network (CTRNet) was established with funding from the Canadian Institute of Health Sciences (CIHR) Institute of Cancer Research (ICR) to foster translational research through improved access to high quality tumour biospecimens. Consistent with this mandate, CTRNet has focused on the establishment and deployment of common standards to harmonize biospecimen quality and approaches to governance. More recently, CTRNet has implemented a certification program to communicate these standards in conjunction with simultaneous exposure to education focusing on the rationale and foundations underlying these standards. The CTRNet certification program comprises registration and certification steps as two linked phases. In the registration phase, launched in November 2011, biobanks are registered into the system and individuals complete an introductory educational module. In the subsequent certification phase, the type of biobank is classified and assigned relevant educational modules and adoption of relevant standards of practice is confirmed through review of documentation including policies and protocols that address the CTRNet Required Operational Practices (ROPs). An important feature of the program is that it is intended for all types of tumor biobanks, so the scope and extent of assessment is scaled to the type of biobank. This program will provide an easily adoptable and flexible mechanism to communicate common standards through education and address both quality assurance and governance across the broad spectrum of biobanks.
129Xe Gas-Transfer MRI RBC-to-Barrier Ratio in Post-Acute COVID19 Syndrome: Clinically-relevant? (2023)

Post-acute COVID19 syndrome (PACS) is an umbrella term for a syndrome of symptoms persisting at least 12 weeks post COVID19 infection. Preliminary studies in PACS patients post-hospitalization revealed abnormally low 129 Xe RBC-to-barrier ratios, but the clinical relevance of this is not well-understood. We acquired 129 Xe gas-transfer MRI, spirometry, diffusing-capacity-of-the-lung for carbon-monoxide (DL CO ) and same-day CT in 39 participants including 30 PACS and 9 never-COVID19 controls. The 129 Xe MRI RBC-to-barrier ratio was significantly related to DL CO and significantly lower in both never-hospitalized and ever-hospitalized PACS patients compared to never-COVID19 controls.
A Quantitative Promoter Methylation Profile of Prostate Cancer (2004)

Our data demonstrate the existence of a progressive increase of promoter methylation levels of several cancer-related genes in prostate carcinogenesis, providing additional markers to augment molecular detection of prostate carcinoma. Because methylation levels of GSTP1, APC, and RASSF1A are associated with advanced grade and stage, QMSP might augment the pathologic indicators currently used to predict tumor aggressiveness.
Enteroviral pathogenesis of type 1 diabetes. (2010)

Type 1 diabetes (T1D) is an autoimmune disease characterized by the disturbance of pancreatic insulin-producing cells, which results in hyperglycemia. The disease is associated with severe complications that impair the quality of life of individuals. The cause of T1D is unknown. Development of the disease is the result of interactions between immunological, genetic, and environmental factors. Viruses are thought to play an important role in the initiation or acceleration of the disease. This is an important issue since it opens the possibility to develop new preventive and therapeutic strategies to fight the disease. The role of enteroviruses in the development of T1D, in particular type B coxsackieviruses, is supported by epidemiological observations. It has been demonstrated that enterovirus infections were significantly more common in recently diagnosed diabetic patients, compared with control subjects. Enteroviral RNA and/or proteins can be detected in blood samples and intestine biopsies of patients with T1D. The hypothesis of a relationship between enteroviruses and the disease has been strengthened by the presence of enteroviral components or infectious particles in the pancreas of patients with T1D. In this review, arguments in favor of a relationship between enterovirus infections and T1D and the mechanisms of the enteroviral pathogenesis of the disease are presented.
Introduction to embedded systems week 2006 special issue (2008)

introduction Share on Introduction to embedded systems week 2006 special issue Editors: Soonhoi Ha Seoul National University Seoul National UniversityView Profile , Kiyoung Choi Seoul National University Seoul National UniversityView Profile , Taewhan Kim Seoul National University Seoul National UniversityView Profile , Krisztian Flautner ARM Ltd. U.K. ARM Ltd. U.K.View Profile , Sanglyul Min Seoul National University Seoul National UniversityView Profile , Wang Yi Uppsala University Uppsala UniversityView Profile Authors Info & Claims ACM Transactions on Embedded Computing SystemsVolume 7Issue 2Article No.: 8pp 1–3https://doi.org/10.1145/1331331.1331332Published:29 January 2008Publication History 0citation445DownloadsMetricsTotal Citations0Total Downloads445Last 12 Months3Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
A polynomial-time algorithm for optimizing channel selection in Cognitive Radio Networks (2013)

Cognitive Radio Network (CRN) technology allows secondary users (SUs) to transmit data exploiting the wireless resources not utilized by licensed primary users (PUs). Channel exploration by SUs for finding transmission opportunities incurs non-negligible costs and is a key challenge in successful operation of CRN. In this paper, we investigate the joint effect of channel exploration order and stopping rule for channel selection with the goal of maximizing SUs' throughput. The main contribution of this paper is the near optimal exploration order and optimal stopping rule, paired with a new and more general characterization of PUs' traffic configurations in CRN. The proposed algorithm uses an analytical model that incorporates channel and PUs' activity history to make the best decision at each decision point, according to the current SUs' exploration results. The simulation study shows that the proposed algorithm significantly improves the SUs' throughput over the existing methods. The proposed optimal stopping algorithm runs in polynomial-time, which is another major contribution of this paper, since it is a significant complexity reduction from the typical exponential order of backward induction algorithms.
Comparative Study on the Separate Extraction of Interface and Bulk Trap Densities in Indium Gallium Zinc Oxide Thin-Film Transistors Using Capacitance–Voltage and Current–Voltage Characteristics (2021)

The interface and bulk trap densities were separately extracted from self-aligned top-gate (SA-TG) coplanar indium gallium zinc oxide (IGZO) thin-film transistors (TFTs) using the low-frequency capacitance–voltage (C–V) characteristics and space-charge-limited current (SCLC) under the flat-band condition. In the method based on the C–V curve, the energy distribution of the interface trap density was extracted using the low-frequency C–V characteristics, and that of the bulk trap density was obtained by subtracting the density of interface trap states from the total subgap density of states (DOS) at each energy level. In the SCLC-based method, the energy distribution of the bulk trap density was extracted using the SCLC under the flat-band condition at high drain-to-source voltages, and that of the interface trap density was obtained by subtracting the density of bulk trap components from the total subgap DOS at each energy level. In our experiments, the two characterization techniques provided very similar interface and bulk trap densities and showed that approximately 60% of the subgap states originate from the IGZO/SiO2 interface at the conduction band edge in the fabricated IGZO TFTs, although the two characterization techniques are based on different measurement data. The results of this study confirm the validity of the characterization techniques proposed to separately extract the interface and bulk trap densities in IGZO TFTs. Furthermore, these results show that it is important to reduce the density of interface trap states to improve the electrical performance and stability of fabricated SA-TG coplanar IGZO TFTs.
The Effect of Self-Reported Visual Impairment and Sleep on Cognitive Decline: Results of the Hispanic Community Health Study/Study of Latinos (2023)

Self-reported visual impairment was independently associated with worse cognitive function and decline.
Asymptotically convergent modified recursive least-squares with data-dependent updating and forgetting factor for systems with bounded noise (1987)

Continual updating of estimates required by most recursive estimation schemes often involves redundant usage of information and may result in system instabilities in the presence of bounded output disturbances. An algorithm which eliminates these difficulties is investigated. Based on a set theoretic assumption, the algorithm yields modified least-squares estimates with a forgetting factor. It updates the estimates selectively depending on whether the observed data contain sufficient information. The information evaluation required at each step involves very simple computations. In addition, the parameter estimates are shown to converge asymptotically, at an exponential rate, to a region around the true parameter.
Contribution of tuberculosis to slim disease in Africa (1994)

Wasting and chronic diarrhoea are late stage manifestations of HIV disease in Africa. The importance of tuberculosis as a contributing factor in the pathogenesis of the slim syndrome has been underestimated. In nearly half of patients dying with severe wasting, tuberculosis was the dominant pathological finding.
Solid state NMR study on the effects of fire retardants on the thermal degradation of a flexible polyurethane foam (2000)

This study was to ascertain the effects of fire retardants on the thermal degradation of a flexible polyurethane foam
Differentially Private Set Union (2021)

We study the basic operation of set union in the global model of differential privacy. In this problem, we are given a universe $U$ of items, possibly of infinite size, and a database $D$ of users. Each user $i$ contributes a subset $W_i \subseteq U$ of items. We want an ($\epsilon$,$\delta$)-differentially private algorithm which outputs a subset $S \subset \cup_i W_i$ such that the size of $S$ is as large as possible. The problem arises in countless real world applications; it is particularly ubiquitous in natural language processing (NLP) applications as vocabulary extraction. For example, discovering words, sentences, $n$-grams etc., from private text data belonging to users is an instance of the set union problem.Known algorithms for this problem proceed by collecting a subset of items from each user, taking the union of such subsets, and disclosing the items whose noisy counts fall above a certain threshold. Crucially, in the above process, the contribution of each individual user is always independent of the items held by other users, resulting in a wasteful aggregation process, where some item counts happen to be way above the threshold. We deviate from the above paradigm by allowing users to contribute their items in a {\em dependent fashion}, guided by a {\em policy}. In this new setting ensuring privacy is significantly delicate. We prove that any policy which has certain {\em contractive} properties would result in a differentially private algorithm. We design two new algorithms for differentially private set union, one using Laplace noise and other Gaussian noise, which use $\ell_1$-contractive and $\ell_2$-contractive policies respectively and provide concrete examples of such policies. Our experiments show that the new algorithms in combination with our policies significantly outperform previously known mechanisms for the problem.
Experimental demonstration of the hybrid opto-electronic correlator for target recognition (2017)

Optical target recognition using correlators is an important technique for fast verification and identification of images. The hybrid opto-electronic correlator (HOC) recently proposed by us bypasses the need for nonlinear materials such as photorefractive polymer films by using detectors instead, and the phase information is yet conserved by the interference of plane waves with the images. In this paper, we demonstrate experimentally the basic working principle of the HOC architecture using currently available technologies. For matched reference and query images, the output signal shows a sharp peak, indicating a match is found. For an unmatched case, a much lower peak value is observed, indicating no match. We also demonstrate the dependence of the output signal on the phases of the interfering plane waves and describe a technique using an interferometer and a servo for optimizing the output signal. As such, the work reported here paves the way for further development of the HOC for practical applications.
Challenges of the current precision medicine approach for pancreatic cancer: A single institution experience between 2013 and 2017 (2020)

Recent research on genomic profiling of pancreatic ductal adenocarcinoma (PDAC) has identified many potentially actionable alterations. However, the feasibility of using genomic profiling to guide routine clinical decision making for PDAC patients remains unclear. We retrospectively reviewed PDAC patients between October 2013 and December 2017, who underwent treatment at the Johns Hopkins Hospital and had clinical tumor next-generation sequencing (NGS) through commercial resources. Ninety-two patients with 93 tumors tested were included. Forty-eight (52%) patients had potentially curative surgeries. The median time from the tissue available to the NGS testing ordered was 229 days (interquartile range 62-415). A total of three (3%) patients had matched targeted therapies based on genomic profiling results. Genomic profiling guided personalized treatment for PDAC patients is feasible, but the percentage of patients who receive targeted therapy is low. The main challenges are ordering NGS testing early in the clinical course of the disease and the limited evidence of using a targeted approach in these patients. A real-time department level genomic testing ordering system in combination with an evidence-based flagging system for potentially actionable alterations could help address these shortcomings.
ChemInform Abstract: NMR‐KONTAKTVERSCHIEBUNG, INFRAROT‐ UND ELEKTRONENSPEKTREN VON BIS‐(STILBENDIAMIN)‐NICKEL(II)‐KOMPLEXEN (1970)

Abstract Die relativen Bindungsstärken der axialen Liganden in den teils nach bekannten Methoden aus dem Perchloratkomplex (I) und dem entsprechenden Na‐ oder Ni‐Carboxylat dargestellten Komplexen (II) werden abgeschätzt.
Pembrolizumab in Relapsed and Refractory Mycosis Fungoides and Sézary Syndrome: A Multicenter Phase II Study (2019)

Pembrolizumab demonstrated significant antitumor activity with durable responses and a favorable safety profile in patients with advanced MF/SS.
Particle removal characteristics in liquid flow during wafer rotation (2018)

With the miniaturization of the semiconductor, the slurry size used in CMP process tends to become small, and it is demanded to clean wafer efficiently after CMP. Therefore characteristic of particle removal in the liquid flow on a rotating wafer is investigated using the pollution sample wafer with the silica particle. Furthermore, particle removal properties in the liquid flow on a rotating wafer is clarified by comparing it with the visualization image of the liquid flow on a rotating wafer.