gebhart/patrepeval huggingface dataset:
Invited Poster: makeSense: Easy Programming of Integrated Wireless Sensor Networks (2011)

Abstract — WSNs are expected to play a critical role in the next computing revolution, as depicted in the visions of Cooperating Objects and the Internet of Things. However, designing and developing WSN software is currently very difficult. This may prevent WSNs from reaching large-scale adoption, especially in industry. The makeSense project aims at enabling an easier integration of WSNs in business processes, by allowing business process experts and WSN developers to express the high-level functionality required, while leaving low-level details to the compiler and run-time system. We envision the results of makeSense to be not only a landmark for WSN software development, but also a new way to look at WSN programming that increases productivity and business value, enabling a far-reaching adoption in key industrial domains. I.
Complexity reduction of frequency-domain Volterra-based nonlinearity post-compensation using symmetric electronic dispersion compensation (2014)

Using symmetric electronic dispersion compensation, root-raised-cosine pulse shaping, and DFT block length optimization, the complexity of single-step frequency domain Volterra-based fiber nonlinearity compensation is reduced by a factor of 2.4, for a 3600 km 128 Gbit/s DP 16-QAM link.
Stromal Interferon-γ Signaling and Cross-Presentation Are Required to Eliminate Antigen-Loss Variants of B Cell Lymphomas in Mice (2012)

To study mechanisms of T cell-mediated rejection of B cell lymphomas, we developed a murine lymphoma model wherein three potential rejection antigens, human c-MYC, chicken ovalbumin (OVA), and GFP are expressed. After transfer into wild-type mice 60-70% of systemically growing lymphomas expressing all three antigens were rejected; lymphomas expressing only human c-MYC protein were not rejected. OVA expressing lymphomas were infiltrated by T cells, showed MHC class I and II upregulation, and lost antigen expression, indicating immune escape. In contrast to wild-type recipients, 80-100% of STAT1-, IFN-γ-, or IFN-γ receptor-deficient recipients died of lymphoma, indicating that host IFN-γ signaling is critical for rejection. Lymphomas arising in IFN-γ- and IFN-γ-receptor-deficient mice had invariably lost antigen expression, suggesting that poor overall survival of these recipients was due to inefficient elimination of antigen-negative lymphoma variants. Antigen-dependent eradication of lymphoma cells in wild-type animals was dependent on cross-presentation of antigen by cells of the tumor stroma. These findings provide first evidence for an important role of the tumor stroma in T cell-mediated control of hematologic neoplasias and highlight the importance of incorporating stroma-targeting strategies into future immunotherapeutic approaches.
Abstract C172: Efficacy of AMG 479, alone and in combination with cisplatin, in ovarian carcinoma xenograft models (2009)

Abstract AMG 479, a fully human monoclonal antibody raised to the type I insulin-like growth factor receptor (IGF1R), is currently being studied in the treatment of patients with ovarian carcinoma. We have previously shown that AMG 479 inhibits the growth of pancreatic and sarcoma tumor models by inhibiting IGF1R signaling through ligand blockade and receptor internalization and degradation. In the present study, we tested the ability of AMG 479 to inhibit the growth of four human ovarian carcinoma xenografts (OV-90, SK-OV3, TOV-21G, and OV-CAR3) in nude mice. Recent evidence has shown that multiple players in the IGF-axis are differentially regulated in human ovarian serous carcinomas, suggesting that the IGF1R pathway may play an important role in the growth of these tumors. The OV-90 model showed exquisite sensitivity to single-agent AMG 479, reaching significant (p&amp;lt;0.0001) tumor growth inhibition (TGI) of more than 90% with 100 or 300 g AMG 479/dose administered twice per week for the duration of the experiment. The OV-CAR3 model was also sensitive to single-agent AMG 479 and showed significant (p&amp;lt;0.0001) TGI of about 50% with 300 g AMG 479/dose, twice per week. The TOV-21G and SK-OV3 models showed resistance to AMG 479 with no significant TGI achieved at any dose. The OV-90 (sensitive) and TOV-21G (resistant) models were used to further characterize the AMG 479 response in a sensitive and a resistant model. AMG 479 effectively inhibited both IGF1R and Akt activity in the OV-90 model but not in the TOV-21G model in vitro. Furthermore, analysis of tumor xenografts collected at the end of the experiment revealed that TGI in the OV-90 model correlated with 50% receptor downregulation (total IGF1R), 90% inhibition of receptor activation (phospho IGF1R), and 50% inhibition of Akt activity, while no measurable inhibition in these analytes were detected in the TOV-21G xenografts. The potential benefit of combining AMG 479 with platinum-based therapy was assessed by combination with cisplatin in the moderately sensitive OVCAR-3 model. Treatment with AMG 479 (300 g/dose, twice per week) in combination with cisplatin (2.5 mg/kg, twice per week) resulted in significant (p=0.0001 vs. AMG 479, p=0.0005 vs. cisplatin) TGI compared with either therapy alone, suggesting that the two agents can be combined clinically for the treatment of ovarian carcinoma patients. Together, the data suggest that AMG 479 has therapeutic potential in treating ovarian carcinoma patients both as monotherapy and in combination with standard of care agents. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):C172.
Helicobacter pylori in vivo causes structural changes in the adherent gastric mucus layer but barrier thickness is not compromised (1998)

A partial breakdown in gel forming structure of the gastric mucus barrier does occur in H pylori infection per se but this is insufficient to cause a collapse of the mucus barrier.
Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer (2001)

Wild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expression was seen in 19 (48.7%) cases. These tumours had more lymph-node metastasis (P = 0.048) and tended to have a poorer survival (P = 0.07). Missense mutations of p53 were detected in 20 (51.3%) patients and had a significantly stronger COX-2 expression than tumours without p53 mutation (P = 0.016). Our results suggest a link between p53 mutation and COX-2 overexpression in gastric cancer.
Reaction of 2‐phenyl‐4‐methyl‐Δ2‐oxazolin‐5‐one with imines. A convenient synthesis of 3‐amido‐β‐lactams (1984)

Abstract Azlactone 3a reacted with furan‐2‐aldehyde and thiophene‐2‐aldehyde imines to give corresponding 3‐amido‐β‐lactams in good yields.
Biomechanical Analysis of Antegrade and Retrograde Flexible Intramedullary Nail Fixation of Pediatric Femoral Fractures Using a Synthetic Bone Model (2004)

Biomechanical testing was performed to evaluate the stability of simulated transverse and comminuted femoral fractures after retrograde and antegrade flexible titanium intramedullary nail fixation. Ten synthetic adolescent-sized femoral bone models were used. Five underwent retrograde fixation with two C-shaped nails inserted from medial and lateral entry portals. The other five underwent antegrade fixation using one C- and one S-shaped nail through lateral entry holes just inferior to the greater trochanter. Retrograde nail fixation demonstrated significantly less axial range of motion and greater torsional stiffness than antegrade fixation in both transverse and comminuted fracture patterns. However, there appeared to be a biomechanical trend of greater resistance to shortening for antegrade nails.
Nonlinear particle dynamics in the magnetotail: A laboratory study 1. The experimental configuration and numerical simulation. Interim report (1995)

The authors have performed the initial stages of an experiment designed to investigate particle dynamics in the magnetotail. The results of this experiment lend support to the idea that particle scattering from the magnetotail neutral sheet is not random but that there exist resonances in the number and direction of scattered particles as a function of energy. The effort began with construction and testing of the magnetic field configuration necessary to simulate the quitetime magnetotail field: a neutral sheet magnetic field profile B0(z)x with a superimposed normal field B(2)z. Once complete, electrons of variable energy were injected into the field region created and the scattered current collected by back-scattered and forward-scattered collection plates was analyzed as a function of electron energy. The experiment was used to test the hypothesis that single particle scattering from a neutral sheet type profile as described can be coherent and can, at times, demonstrate resonance effects as a function of energy.
Emerging roles of IL-33 in inflammation and immune regulation (2015)

Interleukin-33 (IL-33) belongs to the IL-1 family of cytokines and has been reported to play multiple roles in host defense, allergies and chronic inflammation. Constitutive expression of IL-33 in epithelial cells ensures rapid immune responses against invading pathogens such as parasites and viruses. Tissue damage caused by pathogens results in the release of extracellular IL-33 that in turn alerts a variety of immune cells such as group 2 innate lymphoid cells (ILC2s), eosinophils, basophils and mast cells. These cells mediate T helper type 2 (Th2) immune responses to destroy pathogens. IL-33 also plays central roles in mediating allergic diseases including asthma and atopic rhinitis. Although the functions of IL-33 in host defense and allergies initially received most attention, focus is turning to its roles in chronic inflammatory diseases. Recent advances, however, have led to problematic results. In addition to Th2 responses, IL-33 also promotes Th1 responses and there have been positive and negative roles reported for IL-33 in inflammatory diseases. This mini-review will summarize IL-33 biology and discuss issues regarding previously unrecognized roles of IL-33.
Statistical Characterization of GLONASS Broadcast Ephemeris Errors (2011)

include GNSS signal and code structures, GNSS receiver architectures, and interference mitigation. She has received the Institute of Navigation (ION) Early Achievement Award. Todd Walter, Ph.D., is a senior research engineer in the
GA201 (RG7160): A Novel, Humanized, Glycoengineered Anti-EGFR Antibody with Enhanced ADCC and Superior In Vivo Efficacy Compared with Cetuximab (2012)

These data suggest that GA201 may be more effective than cetuximab in patients with EGFR-positive solid tumors and may also represent a first-in-class treatment of patients with KRAS-mutated tumors. Clin Cancer Res; 19(5); 1126-38. ©2012 AACR.
Pt Loaded Alumina Ceramic Catalysts for Micro Thermoelectric Hydrogen Sensors (2006)

The micro-thermoelectric hydrogen sensor (micro-THS) detects the hydrogen gas working with the thermoelectric effect of SiGe thin film and the Pt-catalyzed exothermic reaction of hydrogen oxidation. Integration of Pt/alumina ceramic catalyst on the membrane of the micro-THS was evitable to ensure the high sensitivity and long-term stability of the sensor. The various compositions of Pt/alumina ceramic catalysts were milled by a ball-mill technique to improve the dispersion of the catalyst, and were mixed with conventional organic vehicle like paste. The paste was deposited on micro-THS using dispenser method and the effects of the ball-mill technique and catalyst composition on the sensitivity, ΔVs, of the micro-THS for the hydrogen/air mixture gas flow were investigated. The shape of ceramic catalyst became uniform, and agglomeration of catalyst powder could not be observed using ball-mill technique. The 10 mass% Pt/alumina ceramic catalyst was the optimized platinum content of the ball-milled powder paste, and the micro-THS with this catalyst produced the larger voltage signal of 12.2 mV at the operating temperature of 100°C.
(Invited) Solution Processed Oxide Thin Film Transistors (2014)

The performance of oxide thin-film-transistors (TFTs) by solution process is investigated. From the choice of precursors to the TFTs, each step has its own importance to produce high performance TFTs. The TFT performance is also enhanced by the use of high-k dielectrics such as aluminum oxide (AlO x ) instead of silicon dioxide (SiO 2 ). We discuss the performance of both crystalline (SnO 2 , In 2 O 3 ) and amorphous (ZTO, IZTO) active materials, manufactured by inkjet-printing. Field-effect mobility of 110cm 2 /Vs is achieved.
LeucosceptrineA Novel Sesterterpene with Prolylendopeptidase Inhibitory Activity from Leucosceptrum canum (2004)

A novel sesterterpene, leucosceptrine, was isolated from the medicinal plant Leucosceptrum canum from Nepal. The structure was determined by single-crystal X-ray diffraction and spectroscopic techniques. The biosynthesis of leucosceptrine (1) is proposed here. Leucosceptrine (1) exhibited prolylendopeptidase inhibitory activity.
2016 ASMS Workshop Review: Next Generation LC/MS: Critical Insights and Future Perspectives (2017)

ADVERTISEMENT RETURN TO ISSUEPREVResearch ArticleNEXT2016 ASMS Workshop Review: Next Generation LC/MS: Critical Insights and Future PerspectivesHongying GaoHongying GaoInnovo Bioanalysis, LLC, Mansfield, MA, USAMore by Hongying Gao, Alexander MakarovAlexander MakarovThermo Fisher Scientific, Bremen, GermanyMore by Alexander Makarov, and Richard D. SmithRichard D. SmithPacific Northwest National Laboratory, Richland, WA, USAMore by Richard D. SmithCite this: J. Am. Soc. Mass Spectrom. 2017, 28, 7, 1248–1249Publication Date (Web):April 17, 2017Publication History Published online17 April 2017Published inissue 1 July 2017https://pubs.acs.org/doi/10.1007/s13361-017-1664-5https://doi.org/10.1007/s13361-017-1664-5research-articleACS PublicationsCopyright © 2017 © American Society for Mass Spectrometry 2017Request reuse permissionsArticle Views21Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Multi-physics system simulation for wind turbines with permanent magnet generator and full conversion power electronics (2013)

A comprehensive model for a full-conversion wind turbine is presented in this paper. Multiple mathematical algorithms and software tools were developed and coupled together in a large electrical, mechanical, and controls co-simulation system in order to achieve an optimal balance between computational time and model accuracy. The paper introduces a building-block approach, which starts from the component level and achieves wind turbine system-level simulation integration through a collection of freeware and commercial software. The paper also introduces a unified dq control on the generator and grid side, a generator model and a DC link voltage control scheme that incorporates a resistor with chopping current control. Information for subsystem models, such as rotor blades, gearbox, electric generator and power electronics is included. Simulation results are provided for the Department of Energy (DOE) and National Renewable Energy Laboratory (NREL) baseline 750kW wind turbine for which substantial design and experimental data is publically available.
A novel electroless method for the deposition of single-crystalline platinum nanoparticle films on an organic solid matrix in the presence of gold single crystals (2011)

Single-crystalline platinum nanoparticles (Pt-NPs) were directly deposited on and inside an organic solid matrix by a novel electroless galvanic method. The reducing agent was a solid phase confined with both a reducing agent and a stabilizer combined with initially deposited minute gold single crystals (Au-SCs) on the surface (Au-SM). The oxidizing agent (K2PtCl4) was in the aqueous solution phase. The reaction was carried out at the solid–liquid interface system at 80 °C and pH 1. The deposited Pt-NPs formed a uniform silver-grey conductive coating on the top of the Au-SM when the concentration of K2PtCl4 in the solution was 50 mM. The film consisted of single-crystalline Pt-NPs nearly identical in shape and size (∼250 nm). The initially deposited minute Au-SCs by the electroless deposition process were found to catalyze the formation of Pt-NPs having fcc crystal structures with dominating {111} crystal facets. The formation of Pt-NPs was not observed in the absence of initially deposited Au-SCs on the solid matrix. This method was also applicable for the deposition of deep ruby-red, optically transparent and mechanically stable Pt-NPs on and inside the Au-SM for lower concentrations of K2PtCl4 (1 to 5 mM) in the solution phase. This characteristic color was due to the strong surface plasmon absorption of Pt-NPs in the visible range. The Pt atoms initially deposited on the surface and diffused through the entire Au-SM to the opposite side that was not in contact with the oxidizing agent during the period of the reaction. The Pt-NPs on the solution-side of the Au-SM were partially naked and stabilized only from the bottom side, i.e., the upper sides of these nanocrystals were free from the stabilizer coating. The Au-SCs immobilized thiol-based epoxy resin was used as the Au-SM. The proposed Au-SM method was also applicable for the formation of ruby-red iron, palladium and beautiful, rainbow-like colorful silver nanoparticles on the Au-SM surface.
J1201-2-2 A Measures Planning Method by Analysis of Contribution of the Vibration Transfer Path (2009)

This paper describes a proposal of techniques on Transfer Path Analysis (TPA) to analyze transmission of vibration among the components in a complex structure. This proposal is evolved from the previous one in the dimension which dominates the quality of the analysis in automotive body structure by TPA. The proper coordinate transformation was introduced to resolve the troublesome process on the application of the body structure in the previous proposal. The complications are caused by the treatment with a lot of transfer functions and transmitted forces at the conjunctions that are complexly assembled with many adjacent nodes. Dimension of the analytical region is expanded from two to three in this study. That is, from the cross section of interface of components to the structure itself where the vibration transmits between two components. Coordinate transformation of the transmission is expressed by modal degree of freedom of the component and this makes easy to understand the vibration transmission by the three-dimensional image. The proposed approach is verified by an application to a structure consisted of roof and pillars.
Asymmetric Diels Alder reactions and Michael type additions with 6(R)-3’(R)-Pantolactone-substituted-2H-Pyran-3(6H)-one. (1991)

The preparation of optically pure pyranone 2a, using d-pantolactone as a chiral auxiliairy, and its successful application in Diels Alder and Michael type additions with d.r.'s of 89/11 up to 100/0 is described.
QCM-D and NanoTweezer measurements to characterize the effect of soil cellulase on the deposition of PEG-coated TiO2nanoparticles in model subsurface environments (2018)

Complementary QCM-D and NanoTweezer measurements are used to examine the impact of a ubiquitous soil enzyme on nanoparticle–surface interactions.
NEP: web server for epitope prediction based on antibody neutralization of viral strains with diverse sequences (2014)

Delineation of the antigenic site, or epitope, recognized by an antibody can provide clues about functional vulnerabilities and resistance mechanisms, and can therefore guide antibody optimization and epitope-based vaccine design. Previously, we developed an algorithm for antibody-epitope prediction based on antibody neutralization of viral strains with diverse sequences and validated the algorithm on a set of broadly neutralizing HIV-1 antibodies. Here we describe the implementation of this algorithm, NEP (Neutralization-based Epitope Prediction), as a web-based server. The users must supply as input: (i) an alignment of antigen sequences of diverse viral strains; (ii) neutralization data for the antibody of interest against the same set of antigen sequences; and (iii) (optional) a structure of the unbound antigen, for enhanced prediction accuracy. The prediction results can be downloaded or viewed interactively on the antigen structure (if supplied) from the web browser using a JSmol applet. Since neutralization experiments are typically performed as one of the first steps in the characterization of an antibody to determine its breadth and potency, the NEP server can be used to predict antibody-epitope information at no additional experimental costs. NEP can be accessed on the internet at http://exon.niaid.nih.gov/nep.
Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer (2009)

Loss of imprinting (LOI) of insulin-like growth factor 2 (IGF2) is a common event in many cancers and typically activates the maternally silenced allele. The resulting biallelic IGF2 expression correlates strongly with the hypomethylation of a differentially methylated region (DMR) near its promoter. It has also been shown that IGF2 undergoes overexpression in human malignancies; nevertheless, this phenomenon and its link to aberrant DMR methylation have not been reported in colorectal cancer (CRC). The aim of this study was to determine the relationship between IGF2 LOI, overexpression and DMR hypomethylation in CRC. By analyzing IGF2 and H19 methylation in 97 primary CRC and 64 matched normal colorectal tissues, we have shown a significant correlation between IGF2 LOI and DMR hypomethylation of IGF2 and H19. Additionally, when analyzing Affymetrix expression data of 167 primary CRC tumors and 32 normal tissues, 15% of tumors showed marked IGF2 elevation. We further investigated if substantially elevated IGF2 levels were linked to IGF2 or H19 hypomethylation, but found no significant correlation. However, we demonstrated that noticeable IGF2 overexpression, rather than LOI, negatively correlated with CRC microsatellite instability. These observations indicate that IGF2 expression, particularly when transcribed at significantly high levels, is a result of mechanisms unrelated to LOI. Our results suggest that IGF2 participates in CRC tumorigenesis through 2 different forms of aberrant gene expression.
The MIRAS demonstrator pilot project: Towards SMOS (2002)

Introduction A first article about MIRAS was published in the November 1997 issue of the ESA Bulletin, in which we presented the results of the feasibility study of a two-dimensional aperture-synthesis radiometer for soil moisture and ocean salinity observations. In the meantime, the Soil Moisture and Ocean Salinity (SMOS) mission was selected in 1999 for Phase-A feasibility study as the second ESA Earth Explorer of a big reflector, and thus the technology research efforts of the Payload System Division at ESTEC have focused on this technique, more commonly known as ‘interferometry’.