gebhart/patrepeval huggingface dataset:
Quantitative Species Measurements in Microgravity Combustion Flames (2001)

Flame-vortex interactions are canonical configurations that can be used to study the underlying processes occurring in complicated turbulent reacting flows. The elegant simplicity of the flame-vortex interaction permits the study of these complex interactions under relatively controllable experimental configurations, in contrast to direct measurements in turbulent flames. The ability to measure and model the fundamental phenomena that occur in a turbulent flame, but with time and spatial scales which are amenable to our diagnostics, permits significant improvements in the understanding of turbulent combustion under both normal and reduced gravity conditions. In this paper, we report absolute mole fraction measurements of methane in a reacting vortex ring. These microgravity experiments are performed in the 2.2-sec drop tower at NASA Glenn Research Center. In collaboration with Drs. Chen and Dahm at the University of Michigan, measured methane absorbances are incorporated into a new model from which the temperature and concentrations of all major gases in the flame can be determined at all positions and times in the development of the vortex ring. This is the first demonstration of the ITAC (Iterative Temperature with Assumed Chemistry) approach, and the results of these computations and analyses are presented in a companion paper by Dahm and Chen at this Workshop. We believe that the ITAC approach will become a powerful tool in understanding a wide variety of combustion flames under both equilibrium and non-equilibrium conditions.
Spreadsheets in RDBMS for OLAP (2003)

One of the critical deficiencies of SQL is lack of support for n-dimensional array-based computations which are frequent in OLAP environments. Relational OLAP (ROLAP) applications have to emulate them using joins, recently introduced SQL Window Functions [18] and complex and inefficient CASE expressions. The designated place in SQL for specifying calculations is the SELECT clause, which is extremely limiting and forces the user to generate queries using nested views, subqueries and complex joins. Furthermore, SQL-query optimizer is pre-occupied with determining efficient join orders and choosing optimal access methods and largely disregards optimization of complex numerical formulas. Execution methods concentrated on efficient computation of a cube [11], [16] rather than on random access structures for inter-row calculations. This has created a gap that has been filled by spreadsheets and specialized MOLAP engines, which are good at formulas for mathematical modeling but lack the formalism of the relational model, are difficult to manage, and exhibit scalability problems. This paper presents SQL extensions involving array based calculations for complex modeling. In addition, we present optimizations, access structures and execution models for processing them efficiently.
Single photon emission with a Gaussian far-field at telecom wavelength from single InAs/InP quantum dot-nanowires monolithically grown on Si (2019)

International audience
Mortality in Patients with Brainstem Cavernous Malformations (2021)

The BSCM-associated mortality rate in patients managed conservatively is almost as low as in patients treated surgically and much lower than in frequently cited reports, most probably due to the good selection nowadays in regard to surgery.
The Degrees of Freedom of MIMO Relay under Coherence Diversity (2019)

This paper studies the MIMO relay with non-identical link coherence times, a condition that is denoted coherence diversity. This can occur, e.g., when the nodes do not all have the same mobility, or the scatterers around some nodes have different mobility than others. Obviously this condition occurs in practice therefore the model is well motivated, but the performance of a relay under such conditions has not been studied to date. This paper calculates achievable degrees of freedom under this condition. Since different coherence times have a prominent impact on channel training, channel state is not made available to the decoder for free, and all channel training resources are accounted for in the calculations. A product superposition technique is employed at the source that allows a more efficient usage of degrees of freedom when the relay and the destination have different training requirements. Following the analysis of a representative example, a general analysis is provided and varying configurations of coherence times are studied. Numerical results demonstrate the gains of the proposed approach under coherence disparity.
Autoantigen-specific interactions with CD4+thymocytes control mature medullary thymic epithelial cell cellularity (2009)

Medullary thymic epithelial cells (mTECs) are specialized for inducing central immunological tolerance to self-antigens. To accomplish this, mTECs must adopt a mature phenotype characterized by expression of the autoimmune regulator Aire, which activates the transcription of numerous genes encoding tissue-restricted self-antigens. The mechanisms that control mature Aire(+) mTEC development in the postnatal thymus remain poorly understood. We demonstrate here that, although either CD4(+) or CD8(+) thymocytes are sufficient to sustain formation of a well-defined medulla, expansion of the mature mTEC population requires autoantigen-specific interactions between positively selected CD4(+) thymocytes bearing autoreactive T cell receptor (TCR) and mTECs displaying cognate self-peptide-MHC class II complexes. These interactions also involve the engagement of CD40 on mTECs by CD40L induced on the positively selected CD4(+) thymocytes. This antigen-specific TCR-MHC class II-mediated crosstalk between CD4(+) thymocytes and mTECs defines a unique checkpoint in thymic stromal development that is pivotal for generating a mature mTEC population competent for ensuring central T cell tolerance.
741: Microvascular Invasion is Associated with Aggressive Clinicopathological Features and is an Independent Predictor of Survival for Patients with Clear Cell Renal Cell Carcinoma (2006)

You have accessJournal of UrologyDiscussed Poster, Monday, May 22, 2006, 1:00 - 4:00 pm1 Apr 2006741: Microvascular Invasion is Associated with Aggressive Clinicopathological Features and is an Independent Predictor of Survival for Patients with Clear Cell Renal Cell Carcinoma John S. Lam, Daniel Seiler, John T. Leppert, Allan J. Pantuck, George V. Thomas, Jonathan W. Said, Robert A. Figlin, and Arie S. Belldegrun John S. LamJohn S. Lam More articles by this author , Daniel SeilerDaniel Seiler More articles by this author , John T. LeppertJohn T. Leppert More articles by this author , Allan J. PantuckAllan J. Pantuck More articles by this author , George V. ThomasGeorge V. Thomas More articles by this author , Jonathan W. SaidJonathan W. Said More articles by this author , Robert A. FiglinRobert A. Figlin More articles by this author , and Arie S. BelldegrunArie S. Belldegrun More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)32977-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "741: Microvascular Invasion is Associated with Aggressive Clinicopathological Features and is an Independent Predictor of Survival for Patients with Clear Cell Renal Cell Carcinoma." The Journal of Urology, 175(4S), p. 241 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 241 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information John S. Lam More articles by this author Daniel Seiler More articles by this author John T. Leppert More articles by this author Allan J. Pantuck More articles by this author George V. Thomas More articles by this author Jonathan W. Said More articles by this author Robert A. Figlin More articles by this author Arie S. Belldegrun More articles by this author Expand All Advertisement PDF DownloadLoading ...
Assessment of morbidity and mortality by P-POSSUM scoresin Emergency GI Surgeries (2021)

Background: Assessment of morbidity and mortality risk in emergency gastrointestinal surgeries is a fairly difficult challenge. To have a better scientific, reliable, and reproducible method of assessment POSSUM and its modified version PPOSSUM scores have been devised. In this study, we tried to evaluate the P-POSSUM Scores in patients undergoing emergency GI surgical procedures. Methods: This study was done in the Department of General Surgery, PIMS a tertiary care hospital. Consecutive emergency surgical procedures following inclusion and exclusion criteria were selected for the study. A total of n=50 cases were included in the study. P-POSSUM scores were derived for each of the cases and analysis of the predicted morbidity and mortality was compared. Results: The range of 9.9% risk was done to categorize into 10 different groups with increasing order of scores. The highest frequency was observed in 20.1 – 30.0% which was 22% lower frequency scores were observed in higher extremes. The morbidity risk scores show the highest frequency in 32% in the range of &gt; 90.0 cases followed by 80.1 – 90.0 having cases of 28%. Conclusion: P-POSSUM is an accurate and reliable scoring method for assessing morbidity and mortality in emergency Gastrointestinal surgeries. However, it was found to overestimate mortality and morbidity in our patient population. P-POSSUM over-estimates risk for morbidity in lowrisk groups w
Metamaterial-embedded beamforming phased-array antennas for degradable GPS links (2017)

This paper presents an approach to enable a typical GPS receiver to be much less susceptible to intentional disruption such as jamming and change in link environment. Beamforming GPS receivers comprising 4×4 elements or 8×8 ones are designed using metamaterials, for the placement on the body of an aircraft as an airborne vehicle, to cope with the varying angle of incidence with good antenna gain and the low inter-element interference to make the system more robust and adaptive. The design results show the antenna gain much higher than 5 dBi, and the movable circularly polarized beam with the excellent axial ratio at the resonance frequency and low mutual coupling between the elements.
Accurate performance evaluation for the horizontal nanosheet standard-cell design space beyond 7nm technology (2017)

Vertically-stacked horizontal gate-all-around (GAA) Nanosheet structures have been recognized as good candidates for beyond the 7nm technology node to achieve improved power-performance and area scaling compared to FinFET technologies. Full realization of device-performance entitlement in high-performance and high-density chip designs is, therefore, of critical importance. In this paper, we present a quantitative performance evaluation of horizontal Nanosheet structures focused on key design styles as well as unique Nanosheet challenges such as gate-resistance. This analysis was performed with a fully developed design kit over a wide range of sub-7nm design, including various cell heights, as well as design features such as M1 power staples and performance-aware designs for smaller track cells.
Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs (1995)

Forty-four sulfa drugs were screened against crude preparations of recombinant Pneumocystis carinii dihydropteroate synthetase. The apparent Michaelis-Menten constants (Km) for p-aminobenzoic acid and 7,8-dihydro-6-hydroxymethylpterin pyrophosphate were 0.34 +/- 0.02 and 2.50 +/- 0.71 microM, respectively. Several sulfa drugs, including sulfathiazole, sulfachlorpyridazine, sulfamethoxypyridazine, and sulfathiourea, inhibited dihydropteroate synthetase approximately as well as sulfamethoxazole, as determined by the concentrations which cause 50% inhibition and/or by Ki. For all sulfones and sulfonamides tested, unsubstituted p-amino groups were necessary for activity, and sulfonamides containing an N1-heterocyclic substituent were found to be the most effective inhibitors. Folate biosynthesis in isolated intact P. carinii was approximately equally sensitive to inhibition by sulfamethoxazole, sulfachlorpyridazine, sulfamethoxypyridazine, sulfisoxazole, and sulfathiazole. Two of these drugs, sulfamethoxypyridazine and sulfisoxazole, are known to be less toxic than sulfamethoxazole and should be further evaluated for the treatment of P. carinii pneumonia.
Distributed Bragg feedback intensity modulator in Ti:LiNbO 3 (2005)

A distributed feedback electro-optic intensity modulator in Ti:LiNbO3, utilising Bragg reflectors etched in an amorphous Si overlay film, is demonstrated. A maximum modulation depth of 94% is realised at an operating wavelength of 1542 nm.
Prediction of sustained harmonic walking in the free-living environment\n using raw accelerometry data (2015)

Objective. Using raw, sub-second level, accelerometry data, we propose and\nvalidate a method for identifying and characterizing walking in the free-living\nenvironment. We focus on the sustained harmonic walking (SHW), which we define\nas walking for at least 10 seconds with low variability of step frequency.\nApproach. We utilize the harmonic nature of SHW and quantify local periodicity\nof the tri-axial raw accelerometry data. We also estimate fundamental frequency\nof observed signals and link it to the instantaneous walking (step-to-step)\nfrequency (IWF). Next, we report total time spent in SHW, number and durations\nof SHW bouts, time of the day when SHW occurred and IWF for 49 healthy, elderly\nindividuals. Main results. Sensitivity of the proposed classification method\nwas found to be 97%, while specificity ranged between 87% and 97% and\nprediction accuracy between 94% and 97%. We report total time in SHW between\n140 and 10 minutes-per-day distributed between 340 and 50 bouts. We estimate\nthe average IWF to be 1.7 steps-per-second. Significance. We propose a simple\napproach for detection of SHW and estimation of IWF, based on Fourier\ndecomposition. The resulting approach is fast and allows processing of a\nweek-long raw accelerometry data (approx. 150 million measurements) in\nrelatively short time (~half an hour) on a common laptop computer (2.8 GHz\nIntel Core i7, 16 GB DDR3 RAM).\n
A covalent complex between retroviral integrase and nicked substrate DNA. (1991)

Purified retroviral integrase (IN) from avian sarcoma-leukosis viruses can appropriately process the termini of linear viral DNA, cleave host DNA in a sequence-independent manner, and catalyze integrative recombination; an exogenous source of energy is not required for these reactions. Using DNA substrates containing radioactive phosphate groups, we demonstrate that IN becomes covalently joined to the new 5' phosphate ends of DNA produced at sites of cleavage. Most of the phosphodiester linkages between IN and DNA involve serine, but some involve threonine. Computer-assisted alignment of 80 retroviral and retrotransposon IN sequences identified one serine that is conserved in all of these proteins and three less-conserved threonine residues. These results identify candidate active-site residues and provide support for the participation of a covalent IN-DNA intermediate in retroviral integration.
Correction: Pyocycanin, a Contributory Factor in Haem Acquisition and Virulence Enhancement of Porphyromonas gingivalis in the Lung (2016)

The word “Pyocyanin” is misspelled in the article title. The correct title is: Pyocyanin, a Contributory Factor in Haem Acquisition and Virulence Enhancement of Porphyromonas gingivalis in the Lung. The correct citation is: Benedyk M, Byrne DP, Glowczyk I, Potempa J, Olczak M, Olczak T, et al. (2015) Pyocyanin, a Contributory Factor in Haem Acquisition and Virulence Enhancement of Porphyromonas gingivalis in the Lung. PLoS ONE 10(2): e0118319. doi:10.1371/journal.pone.0118319

The following information is missing from the Funding section: The Faculty of Biochemistry, Biophysics and Biotechnology of Jagiellonian University is a partner of the Leading National Research Center (KNOW) supported by the Ministry of Science and Higher Education.
Discharge dynamics, plasma kinetics and gas flow effect in argon–acetylene discharges (2021)

Abstract We investigated capacitively coupled Ar/C 2 H 2 RF plasmas with a 1D fluid model that couples a 13.56 MHz discharge module, a long timescale chemical module and a flow transport module. A new solution procedure was developed in order to accurately describe the coupling between the short timescale discharge dynamics and the long characteristic time processes that play a major role in the molecular growth of reactive species. The plasma was simulated for different inlet gas configurations and flowrates. We showed that for a showerhead configuration one may distinguish two situations. For short residence time the plasma was strongly electronegative in the very center of the discharge gap and dominated by large hydrocarbon positive and negative ions. In this situation the acetylene conversion, although moderate, lead to a significant molecular growth. For long residence time, although C 2 H 2 underwent a total conversion, the products of the primary C 2 H 2 dissociation process were consumed by surface deposition which reduced drastically the molecular growth in the short gap discharge considered here. Whatever the conditions, we confirmed the key-role of Ar* in the acetylene conversion, ionization kinetics as well as the subsequent molecular growth for neutral and charged species. We also showed that remote feed gas and showerhead configurations predicted similar results at low flowrate. At larger flowrate the two configurations presented some discrepancy. Especially H 2 density was much larger for the remote feed gas configuration, which affected the overall plasma behavior. Our results highlight that realistic gas-flow models are essential for an accurate description of acetylene conversion in Ar/C 2 H 2 plasma.
Towards Effective Integration of Fault Tolerance and Real Time (Panel). (1994)

During the last decades, nuts have attracted the attention of researchers for their potential benefits in cardiovascular prevention. We discuss here some aspects of the assumed beneficial effects of nuts, weighing them against potential harm. Epidemiological observations and controlled intervention trials consistently suggest that nuts consumption is associated with improved serum lipid profile, thus helping decrease cardiovascular risk. Being nuts an energy dense food, their impact on energy balance and body weight should be considered. In particular, the claim that adding nuts to the habitual diet, thus increasing calorie intake, does not cause body fat accumulation still needs evidence and biological plausibility. The potential risk associated with the relatively frequent occurrence of allergic reactions following the consumption of nuts is also discussed.
Temperature-dependent pseudogap in the oxypnictidesLaFeAsO1−xFxandLaFePO1−xFxseen via angle-integrated photoemission (2009)

We have performed a temperature-dependent angle-integrated laser photoemission study of iron oxypnictide superconductors LaFeAsO:F and LaFePO:F exhibiting critical-transition temperatures (${T}_{c}$'s) of 26 and 5 K, respectively. We find that high-${T}_{c}$ LaFeAsO:F exhibits a temperature-dependent pseudogaplike feature extending over $\ensuremath{\sim}0.1\text{ }\text{eV}$ about the Fermi level at 250 K, whereas such a feature is absent in low-${T}_{c}$ LaFePO:F. We also find $\ensuremath{\sim}20\text{-meV}$ pseudogaplike features and signatures of superconducting gaps in both LaFeAsO:F and LaFePO:F. We discuss the possible origins of the unusual pseudogaplike features through comparison with the high-${T}_{c}$ cuprates.
Design Considerations for AMPET: The Ambulatory Micro-Dose, Wearable PET Brain Imager (2015)

1540 Objectives As part of the BRAIN initiative, we are designing a mobile molecular brain imager that can be used on healthy subjects to study the functioning of the human brain during motion. The Ambulatory Micro-Dose, Wearable PET Brain Imager (AMPET) must be as light as possible while still providing adequate sensitativity and resolution. We report here on initial simulations studies to quantify the AMPET design trade-offs. Methods We used the PET simulation system SimSET to model effects of AMPET design. Although SimSET provides fast and accurate simulations, it is limited to cylindrical volumes and surfaces for PET scanners. We added a new processing layer wherein an outer 9virtual target9 cylinder is used to capture all potential annihiliation photon detection events. These events are then projected back to the AMPET detector surface, which is modelled as a truncated hemisphere. After verification we evaluated the relative coicidence efficiency of three designs for AMPET (radius 12 cm, axial extent of truncated hemisphere of 4 6 and 8 cm, no confounding effects, 100,000 decays). For input we used the 3D Hoffman brain digital reference object (DRO). The DRO mimics 18F-FDG uptake in normal brain, but can be modified to represent uptake of other neuro radiotracers. Results The new approach of simulation of non-cylindrical scanners was verified. Using this approach the base efficiency of the AMPET designs were estimated. Doubling the axial extent of truncated hemisphere from 4 to 8 cm would more than triple the coincidence effeciency (3.5% to 11.4%), but would also double the weight, unless detector thickness is reduced. Conclusions Using simulations of non-cylindrical scanners using the 3D Hoffman brain digital reference object (DRO), we are able to evaluate the performance and design trade-offs for AMPET to optimze the trade-offs between mobility, sensitivity, and resolution. Research Support Suporrted by grant R24 MH106057
Design, Synthesis and Discovery of 1-(2-(6-Chloro-3-methylsulfonyl)-naphthyl)-1H-pyrazole-5-carboxylamides as Highly Potent Factor Xa Inhibitors (2009)

Based upon the biphenyl 1-(2-naphthyl)-1H-pyrazole-5-carboxylamides reported in our previous communications, we designed and discovered 2-(6-chloro-3-methylsulfonyl)-naphthyl as an optimal factor Xa S1 binding element. Employing a key Diels-Alder reaction of 1,4-dihydro-2,3-benzoxathiin-3-oxide with maleic anhydride and a key Cu(I)-mediated methylsulfonylation, we prepared two biphenyl 1-(2-(6-chloro-3-methylsulfonyl)-naphthyl)-1H-pyrazole-5-carboxylamides as highly potent factor Xa inhibitors with K(i) values of 0.065 nM and 0.045 nM respectively, and demonstrated the synergistically enhanced binding interaction in the factor Xa S1 site.