gebhart/patrepeval huggingface dataset:
A Prospective Study of Peritransplant Sorafenib for Patients with FLT3-ITD Acute Myeloid Leukemia Undergoing Allogeneic Transplantation (2019)

FLT3-ITD-mutated acute myeloid leukemia (AML) remains a therapeutic challenge. FLT3 inhibition in the setting of minimal residual disease and a new immune system via allogeneic transplantation offers a promise of improved survival for these patients. We performed a prospective study of patients with FLT3-ITD AML undergoing allogeneic transplant that was conducted to evaluate the safety, tolerability, and outcome of sorafenib administered peritransplant. Sorafenib dosing was individualized, starting at 200 mg twice a day (BID), and titrated based on tolerability or toxicities until a tolerable dose was identified. Forty-four patients, with a median age of 52 years, undergoing allogeneic transplant were started on sorafenib in the peritransplant period (21 pretransplant). The median duration of post-transplant follow-up was 27.6 months (range, 5.2 to 60.4). Overall survival was 76% at both 24 and 36 months. Event-free survival at 24 and 36 months was 74% and 64%, respectively. Ten patients died in the post-transplant period, with 6 deaths due to relapsed leukemia and 4 from transplant-associated toxicity. Tolerable doses ranged from 200 mg every other day to 400 mg BID with similar exposure. Correlative studies evaluating FLT3 inhibition via a plasma inhibitory activity assay showed consistent inhibition of FLT3 at all tolerability-determined dosing levels. Sorafenib is well tolerated in the peritransplant setting irrespective of the conditioning intensity or the donor source. Our findings indicate that sorafenib dosing can be individualized in the post-transplantation setting according to patient tolerability. This approach results in effective in vivo FLT3 inhibition and yields encouraging survival results.
Development of a retroviral construct containing a human mutated dihydrofolate reductase cDNA for hematopoietic stem cell transduction (1994)

A double-copy Moloney leukemia virus-based retroviral construct containing both the NeoR gene and a mutant human dihydrofolate reductase (DHFR) cDNA (Ser31 mutant) was used to transduce NIH 3T3 and mouse bone marrow (BM) progenitor cells. This resulted in increased resistance of these cells to methotrexate (MTX). The transduced BM progenitor cells were returned to lethally irradiated mice. The recipients transplanted with marrow cells infected with the recombinant virus showed protection from lethal MTX toxicity as compared with mock- infected animals. Evidence for integration of the proviral DNA was obtained by amplification of proviral DNA by polymerase chain reaction (PCR) and Southern analysis. Sequencing a portion of the PCR-amplified human DHFR cDNA showed the presence of the mutation. These studies with the human Ser31 mutant DHFR cDNA gave results comparable with those obtained with the mutant murine DHFR cDNA (Leu to Arg22) in developing MTX-resistant BM. The Ser31 mutant human DHFR cDNA is currently being tested for infection of human CD34+ human BM and peripheral blood stem cells in vitro.
Functionalization of silica particles towards cationic polyelectrolytes using vinylformamide and 1,3-divinylimidazolidin-2-one as monomers (2001)

The use of vinylformamide and 1,3-divinylimidazolidin-2-one, bisvinylethylene-urea (BVU), as well as of the poly(vinylformamide-vinylamine) copolymer (PVFA-co-PVAm) for silica surface functionalization has been investigated. Various procedures such as grafting from, crosslinking surface polymerization, and post-functionalization of adsorbed PVAm chains have been experimentally applied. The advantage of the different synthetic methods is discussed with regard to the resulting surface structure of the organic/inorganic hybrid materials.
Probing ergot alkaloid biosynthesis: intermediates in the formation of ring C (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProbing ergot alkaloid biosynthesis: intermediates in the formation of ring CAlan P. Kozikowski, Chinpiao Chen, Jiang Ping Wu, Masaaki Shibuya, Chun Gyu Kim, and Heinz G. FlossCite this: J. Am. Chem. Soc. 1993, 115, 6, 2482–2488Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/ja00059a051https://doi.org/10.1021/ja00059a051research-articleACS PublicationsRequest reuse permissionsArticle Views310Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Aligned carbon nanotubes/fibers for applications in vacuum microwave amplifiers (2006)

Most long-range telecommunication systems are based upon microwave links. The transmitters use microwave amplifiers which in the very near future will be required to work at up to 30–100GHz with output power in the region of a few tens of watts. Carbon nanotubes (CNTs), which exhibit extraordinary field emission properties because of their high electrical conductivity, ideal high aspect ratio whisker-like shape for geometrical field enhancement, and remarkable thermal stability, can be used as the emitter in such applications. This article will describe the plasma enhanced chemical vapor deposition growth of vertically aligned carbon nanotubes, and how well controlled arrays of such structures can be grown. We will also describe how high current densities of ∼1A∕cm2, under direct current and 1.5GHz direct modulation, can be obtained from CNT cathodes. These CNT cold cathodes offer considerable weight and size savings over conventional hot cathodes used in microwave applications (e.g., SATCOM, radar).
Genomic Instability Resulting from Blm Deficiency Compromises Development, Maintenance, and Function of the B Cell Lineage (2009)

The RecQ family helicase BLM is critically involved in the maintenance of genomic stability, and BLM mutation causes the heritable disorder Bloom's syndrome. Affected individuals suffer from a predisposition to a multitude of cancer types and an ill-defined immunodeficiency involving low serum Ab titers. To investigate its role in B cell biology, we inactivated murine Blm specifically in B lymphocytes in vivo. Numbers of developing B lymphoid cells in the bone marrow and mature B cells in the periphery were drastically reduced upon Blm inactivation. Of the major peripheral B cell subsets, B1a cells were most prominently affected. In the sera of Blm-deficient naive mice, concentrations of all Ig isotypes were low, particularly IgG3. Specific IgG Ab responses upon immunization were poor and mutant B cells exhibited a generally reduced Ab class switch capacity in vitro. We did not find evidence for a crucial role of Blm in the mechanism of class switch recombination. However, a modest shift toward microhomology-mediated switch junction formation was observed in Blm-deficient B cells. Finally, a cohort of p53-deficient, conditional Blm knockout mice revealed an increased propensity for B cell lymphoma development. Impaired cell cycle progression and survival as well as high rates of chromosomal structural abnormalities in mutant B cell blasts were identified as the basis for the observed effects. Collectively, our data highlight the importance of BLM-dependent genome surveillance for B cell immunity by ensuring proper development and function of the various B cell subsets while counteracting lymphomagenesis.
Room temperature copper ULSI metallization by low kinetic-energy particle process (2003)

A room-temperature Cu metallization scheme has been established by a low kinetic-energy particle process, in which epitaxial growth of metal films on Si as well as the formation of ideal metal-silicon contacts without alloying heat cycles has been realized. Cu films deposited on SiO/sub 2/ showed excellent adhesion without an intervening glue layer. Ideal Schottky diode characteristics were obtained. The process is compatible with low-temperature high-throughput one-wafer processing. It is suggested that this process help to establish highly flexible metallization processes for custom VLSI circuit fabrication.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Figure 2 from <i>In Vivo</i> Imaging of Drug-Induced Mitochondrial Outer Membrane Permeabilization at Single-Cell Resolution (2023)

&lt;p&gt;PDF file, 289KB, Fig. S2: Histological analysis of HT1080 H2B-mCherry tumors stained with Annexin V.&lt;/p&gt;
[Tick bite fever in West Africa: difficulties in diagnosis of an emerging disease]. (2009)

West African tick bite fever is a prevalent emerging zoonosis from the coast of Senegal to Chad. It is characterized by recurrent fever in association with a deteriorating clinical state. It is now the second most common vector-borne disease in Senegal. The purpose of this report is to describe one case and to review the main clinical and epidemiological features of this disease.
Development of High-Strength Al–Cu–Mg Alloy by Combined Application of High-Pressure Torsion and Aging Treatment (2023)

Solution treated Al–Cu–Mg alloys with three different compositions were subjected to high-pressure torsion (HPT) for 1 to 50 turns, and then aged at 423 K. By conducting HPT process, the hardness of the three alloys significantly increased after 50 turns, and the average grain sizes were refined to 130–140 nm. After aging treatment, the hardness was further increased to 271 HV, 288 HV and 273 HV in the peak aging condition for the Al–4Cu–1.5Mg, Al–4Cu–3Mg and Al–5Cu–3Mg (in mass%) alloys, respectively. The contribution of several strengthening mechanisms was quantitatively evaluated in terms of grain boundary hardening, dislocation hardening, solid solution hardening and cluster/precipitation hardening. It is shown from the quantitative evaluation that simultaneous strengthening due to grain refinement and nanoscale precipitates is successfully achieved by combined application of HPT process and subsequent aging treatment.
Simultaneous Source Separation Using an Annihilation Filter Approach (2016)

Summary Simultaneous shooting increases acquisition efficiency by activating more than one source at the same time. This introduces blending noise that typically needs to be removed before data processing. We present a new deblending algorithm based on iterative annihilation filtering. The strategy attenuates coherent energy using a modified sparse τ-p transform following which the remaining energy is re-aligned to form the deblended output. The method is tested on a numerically blended dataset using real short and long offset narrow-azimuth data. The results show the residual blending noise to be ∼ 25 dB down.
Introduction (2009)

<h3>Objective</h3> To examine the relationship between psychosocial job characteristics and safety climate. <h3>Design</h3> Cross-sectional survey. <h3>Setting</h3> Community pharmacies in Great Britain. <h3>Participants</h3> A random sample of community pharmacists registered in Great Britain (n=860). <h3>Survey instruments</h3> Effort–reward imbalance (ERI) indicator and Job Content Questionnaire (JCQ). <h3>Main outcome measures</h3> Pharmacy Safety Climate Questionnaire (PSCQ). <h3>Results</h3> The profile of scores from the ERI indicated a relatively high risk of adverse psychological effects. The profile of scores from the JCQ indicated both high demand on pharmacists and a high level of psychological and social resources to meet these demands. Path analysis confirmed a model in which the ERI and JCQ measures, as well as the type of pharmacy and pharmacist role, predicted responses to the PSCQ (χ<sup>2</sup>(36)=111.38, p&lt;0.001; Tucker–Lewis index=0.96; comparative fit index=0.98; root mean square error of approximation=0.05). Two general factors (effort vs reward and control vs demand) accounted for the effect of job characteristics on safety climate ratings; each had differential effects on the PSCQ scales. <h3>Conclusions</h3> The safety climate in community pharmacies is influenced by perceptions of job characteristics, such as the level of job demands and the resources available to meet these demands. Hence, any efforts to improve safety should take into consideration the effect of the psychosocial work environment on safety climate. In addition, there is a need to address the presence of work-related stressors, which have the potential to cause direct or indirect harm to staff and service users. The findings of the current study provide a basis for future research to improve the safety climate and well-being, both in the pharmacy profession and in other healthcare settings.
Characterization of Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitors as Stimulators of Steroidogenesis (2013)

Inhibition of GSK-3β has been well documented to account for the behavioral actions of the mood stabilizer lithium in various animal models of mood disorders. Recent studies have showed that genetic or pharmacological inhibition of GSK-3β resulted in anxiolytic-like and pro-social behavior. In our ongoing efforts to develop GSK-3β inhibitors for the treatment of mood disorders, SAR studies on maleimide-based compounds were undertaken. We present herein for the first time that some of these GSK-3β inhibitors, in particular analogues 1 and 9, were able to stimulate progesterone production in the MA-10 mouse tumor Leydig cell model of steroidogenesis without any significant toxicity. These two compounds were tested in the SmartCube behavioral assay and showed anxiolytic-like signatures following daily dose administration (50 mg/kg, ip) for 13 days. Taken together, these results support the hypothesis that GSK-3β inhibition could influence neuroactive steroid production thereby mediating the modulation of anxiety-like behavior in vivo.
Determination of energy window width and position for scintigraphic imaging using different energy resolution detection with the triple energy window (TEW) scatter compensation method (2002)

Since primary photons can provide information concerning the position of radioisotope (RI) accumulation and the energy of the photons, it would seem reasonable to vary the position and width of the energy window depending on the type of RI and the energy resolution of the detector to collect as many of the primary photons as possible. The authors propose a method for determining energy window width and position for scintigraphic imaging to collect as many of the primary photons as possible, and studied the influence on the Triple Energy Window (TEW) scatter compensation method of setting such energy window levels for Tc-99m (single photopeak) and Tl-201 (multiple photopeaks) using detector with different energy resolution through simulation. The Monte Carlo simulations were verified by comparing the regional energy spectrum at the phantom obtained from the simulation against experimental measurements. The energy window with the authors' proposed method for Tc-99m is 20% and 47.3% for Tl-201 using gamma camera, and 9.8% for Tc-99m using a semiconductor detector with a theorized energy resolution of 7.0 keV.
ChemInform Abstract: Synthesis of 2‐Substituted 3‐Phytyl‐1,4‐naphthoquinone Epoxides. (1990)

Abstract 1,4‐Naphthoquinone (I) is converted to the dihydroxy(phytyl)naphthalene (III) by a known method and then formylated and oxidized to give the hydroxymethyl(phytyl)naphthoquinone (V).
Using High-Frequency Downhole Vibration Technology to Enhance through-Tubing Fishing and Workover Operations (2006)

Abstract In coiled tubing conveyed through-tubing fishing operations, conventional jarring technology often creates limitations due to the requirement to repeatedly cycle the coiled tubing over the gooseneck in order to actuate and re-cock the jar. It is well known and documented in our industry that this repeated cycling leads to pipe fatigue and coiled tubing life reduction. Additionally, the low frequency, high-impact of the jarring assembly, may in some cases cause the fish to become wedged tighter. Vibratory and high frequency impact tools have been found to provide operational and economic benefits over hydraulic, time delayed jarring tools in a variety of through tubing fishing and workover applications, particularly in horizontal and extended-reach wells. As opposed to jars, vibratory type impact systems are capable of delivering significant impact forces at the fish with only limited set-down weight or over pull available making them particularly well suited to the constraints of coiled tubing operations. These hydraulically powered systems are configured to deliver downward impacts in compression and upward impacts in tension. Both downward and upward impacts are achieved without the necessity to cycle the coiled tubing between impacts, therefore significantly reducing low-cycle pipe fatigue. Additionally, when a fish is stuck in sand or debris, temporarily suspending or liquefying sand particles by lighter high frequency blows as delivered by an impact tool while over pull is applied offers a higher degree of success in freeing the fish. This paper will outline the uses and advantages of down-hole high-frequency vibration technology from a coiled tubing perspective and also describe the development and laboratory testing results of a new, modular vibratory impact tool offering a significantly reduced operating length yet delivering greater impact thus increasing the operating envelope for such tools adding demonstrable value to a variety of coiled tubing fishing and workover operations.
Tables S11-S12 from Genomic Evolutionary Patterns of Leiomyosarcoma and Liposarcoma (2023)

&lt;p&gt;Supplementary Tables 11-12&lt;/p&gt;
Enhanced Diagnostic Yields of Bacteremia and Candidemia in Blood Specimens by PCR-Electrospray Ionization Mass Spectrometry (2013)

A prospective study was performed to determine the value of direct molecular testing of whole blood for detecting the presence of culturable and unculturable bacteria and yeasts in patients with suspected bloodstream infections. A total of 464 adult and pediatric patients with positive blood cultures matched with 442 patients with negative blood cultures collected during the same period were recruited during a 10-month study. PCR amplification coupled with electrospray ionization mass spectrometry (PCR-ESI-MS) plus blood culture reached an overall agreement of 78.6% in the detection and species-level identification of bacterial and candidal pathogens. Of 33 culture-negative/PCR-ESI-MS-positive specimens, 31 (93.9%) were judged to be truly bacteremic and/or candidemic based on a medical chart review and analytical metrics. Among the 15 culture-positive specimens in which PCR-ESI-MS detected additional bacterial or yeast species, 66.7% and 20.0% of the additional positive specimens by PCR-ESI-MS were judged to be truly or possibly bacteremic and/or candidemic, respectively. Direct analysis of blood samples by PCR-ESI-MS rapidly detects bacterial and yeast pathogens in patients with bloodstream infections. When used in conjunction with blood culture, PCR-ESI-MS enhances the diagnostics of septicemia by shortening test turnaround time and improving yields.
Fusarium Infection in Hematopoietic Stem Cell Transplant Recipients (2004)

To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allogeneic HSCT recipients and 7 in autologous HSCT recipients. The incidence of fusariosis among allogeneic HSCT recipients varied between a range of 4.21-5.0 cases per 1000 in human leukocyte antigen (HLA)--matched related transplant recipients to 20.19 cases per 1000 in HLA-mismatched transplant recipients. The median time period between transplantation and diagnosis of fusariosis was 48 days. Among allogeneic HSCT recipients, a trimodal distribution was observed: a first peak before engraftment, a second peak at a median of 62 days after transplantation, and a third peak >1 year after transplantation. The actuarial survival was 13% (median, 13 days). Persistent neutropenia was the single prognostic factor for death identified by multivariate analysis.
Treatment with Zinc is Associated with Reduced In-Hospital Mortality Among COVID-19 Patients: A Multi-Center Cohort Study (2020)

Zinc with an ionophore was associated with increased rates of discharge home and a 24% reduced risk of in-hospital mortality among COVID-19 patients, while neither zinc alone nor the ionophore alone reduced mortality. Further randomized trials are warranted.
Effect of interferon on phospholipid methylation by peripheral blood mononuclear cells (1982)

The effect of human interferon (IFN) preparations on the metabolic pathway leading to the synthesis of phosphatidylcholine (PC) by a stepwise addition of methyl groups to phosphatidylethanolamine (PE) was investigated in human peripheral blood mononuclear (PBMN) cells. An inhibition of the synthesis of PC via this pathway was regularly observed with both alpha- (recombinant or natural) and beta-IFN. This inhibition was apparent within the first 5 min of treatment, reached its maximum between 15 min and 1 hr, and persisted at the same level until 6 hr, the last time point examined. Each of the transmethylated products of PE underwent a similar inhibition, as measured by the turnover rate of individual products. The intracellular pool of the methyl donors, methionine and S-adenosyl-methionine (SAM), was shown to be unaffected. The methyltransferase activity of IFN-pretreated cell extracts was unchanged. These findings support the hypothesis that IFN induces a functional change in phospholipid methylation at the level of organized membrane-bound phospholipid methyltransferase enzymes in intact cells.
Selective Electroless Nickel Deposition on Patterned Phosphonate and Carboxylate Polymer Films (1996)

Electroless metallization processes have been used to develop photopatterned films of poly(diisopropyl vinylbenzylphosphonate‐co‐N‐methylmaleimide) and deposit metallic nickel selectively in the exposed regions of the films. A 100 Å thick film of nickel provides an effective etch mask to the underlying polymer in an oxygen plasma. Carboxylate polymers can also serve as substrates for electroless nickel deposition. These results suggest that phosphonate or carboxylate polymers could potentially serve as imaging layers for at‐the‐surface imaging approaches to 14 and 193 nm lithography.