gebhart/patrepeval huggingface dataset:
Throughput optimization in disk-based real-time application specific systems (1996)

Traditionally, application specific computations have been focusing on numerically intensive data manipulation. Modern communications and DSP applications, such as WWW, and video-on-demand, however, are increasingly more data management oriented. At the same time, the technological trends indicate that magnetic disk system performance is rapidly becoming a principal component in overall system behavior. We initiate system level research in synthesis of disk-based application specific system by introducing cost and throughput optimization problems for synthesis of disk- based application specific systems. We formulate, establish computational complexity, and develop efficient optimization algorithms for data assignment on a single and multiple disks so that the seek time overhead is minimized. Extensive experimental results clearly indicate the importance of the synthesis problem and effectiveness of the proposed optimization algorithms.
Nonlinear optical activity of chiral surfaces (1994)

Chiral molecules respond in different ways to left- and right-hand circularly-polarized light. The resulting linear phenomena of optical rotation and circular dichroism are explained by contributions of magnetic-dipole transitions to the linear optical properties of chiral media. Similar circular-difference (CD) effects have been predicted to occur also in nonlinear optical processes and have recently been observed in surface second-harmonic (SH) generation.1 We have investigated SH generation from chiral surfaces both experimentally and theoretically and explain the CD effects by magnetic contributions to the second-order nonlinearity.
Effect of octreotide on fluid absorption and secretion by the normal human jejunum and ileum in vivo (2002)

Octreotide causes an increase in the net epithelial cell absorption rate of a balanced electrolyte solution in the normal jejunum and ileum. In the jejunum, this proabsorptive effect is mediated mainly by the reduction of normal active electrolyte secretion, rather than by stimulation of normal active electrolyte absorption. These results support the hypothesis that part of the antidiarrhoeal action of octreotide is due to its effects on active electrolyte transport mechanisms by normal epithelial cells of the small intestine.
Stochastic density functional theory (2019)

Linear‐scaling implementations of density functional theory (DFT) reach their intended efficiency regime only when applied to systems having a physical size larger than the range of their Kohn–Sham density matrix (DM). This causes a problem since many types of large systems of interest have a rather broad DM range and are therefore not amenable to analysis using DFT methods. For this reason, the recently proposed stochastic DFT (sDFT), avoiding exhaustive DM evaluations, is emerging as an attractive alternative linear‐scaling approach. This review develops a general formulation of sDFT in terms of a (non)orthogonal basis representation and offers an analysis of the statistical errors (SEs) involved in the calculation. Using a new Gaussian‐type basis‐set implementation of sDFT, applied to water clusters and silicon nanocrystals, it demonstrates and explains how the standard deviation and the bias depend on the sampling rate and the system size in various types of calculations. We also develop a basis‐set embedded‐fragments theory, demonstrating its utility for reducing the SEs for energy, density of states and nuclear force calculations. Finally, we discuss the algorithmic complexity of sDFT, showing it has CPU wall‐time linear‐scaling. The method parallelizes well over distributed processors with good scalability and therefore may find use in the upcoming exascale computing architectures. This article is categorized under: Electronic Structure Theory &gt; Ab Initio Electronic Structure Methods Structure and Mechanism &gt; Computational Materials Science Electronic Structure Theory &gt; Density Functional Theory
Un modello discreto non-lineare per l'analisi biomeccanica del legamento parodontale (in Italian) - A nonlinear discrete model for the biomechanical analysis of the periodontal ligament (2007)

In questo lavoro si presenta un modello discreto non lineare in grado di riprodurre il comportamento meccanico del legamento parodontale (PDL) sotto condizioni di carico funzionali. Il modello si basa sull’introduzione, in corrispondenza dei nodi computazionali, di catene di elementi discreti, le cui risposte tridimensionali non lineari sono tarate sulla base di caratterizzazioni sperimentali del legamento disponibili in letteratura. Si tiene in conto la variabilità della risposta locale e dello spessore del PDL in relazione alla posizione lungo la radice del dente. Il modello, in grado di contemplare la risposta del legamento per condizioni di carico sia impulsive che quasi-statiche, è stato implementato in un codice commerciale attraverso una formulazione agli elementi finiti in regime di grandi spostamenti. Si presentano applicazioni numeriche relative all’analisi di mobilità di un premolare inferiore e ad un’analisi dell’influenza della modellazione del PDL sulla valutazione delle distribuzioni di tensione nei tessuti dentali.
Optical properties of solid-core photonic crystal fibers filled with nonlinear absorbers (2013)

A theoretical and experimental investigation of the transmission of solid-core photonic crystal fibers (PCFs) filled with nonlinear absorbers shows a sharp change in the threshold for optical limiting and in leakage loss as the refractive index of the material in the holes approaches that of the glass matrix. Theoretical calculations of the mode profiles and leakage loss of the PCF are in agreement with experimental results and indicate that the change in limiting response is due to the interaction of the evanescent field of the guided mode with the nonlinear absorbers in the holes.
Scattering in liquid immersion lithography (2004)

We have measured the intrinsic scattering of water with an eye toward its potential impact on immersion lithography. Quantitative measurements of the elastic Rayleigh scatter agree well with theory and show a loss of 0.001 cm<sup>-1</sup>. Qualitative measurements of the inelastic Raman scattering show a strong peak at 206 nm, consistent with the O-H stretch present in water. Both are expected to contribute flare of < 10<sup>-6 </sup>of the incident intensity. We have also examined the possibility for bubbles in the immersion liquid, and in particular those which form near the resist surface. We have measured scattering from single bubbles and estimate that bubbles as small as 5 &mu;m should be detectable in this fashion. In addition, we have measured the potential for bubbles due to laser induced resist outgassing by direct imaging. In 2500 resist images (~235 mm<sup>2</sup> of surface), we have seen only one bubble candidate which, due to its persistence in the water, we do not believe represents a true outgassing-induced bubble. Finally, using a technique borrowed from biology, rapid cryofixation/freeze fracture, we have examined nanobubbles which form spontaneously on hydrophobic surfaces and found that degassing the water prevents their formation.
Epipolar methods for multi-view sketching (2004)

Single view sketch-based modelers like SKETCH and Teddy can be powerful tools, but sometimes their inferences are inadequate: in Teddy, for example, if one draws an animal shape, the centerline of the tail will always lie in a plane rather than being curved in 3D. In these cases, multiple-view sketching seems like a reasonable solution: a single sketch gets viewed from a new direction, in which further sketching modifies the shape in a way that's consistent with the original sketch. This paper describes a testbed implementation of such a multi-view sketching approach, based on epipolar lines, which is used for multi-view editing of the backbone lines for generalized cylinders. The method works well on many objects, particularly those where precise geometry is not important, but general shape and form must be richer than those with planar symmetry, but is difficult to use in other cases; some difficulties may be related to implementation choices, but we believe that the main problems are tied to the underlying approach, which while mathematically sound proves to be cognitively difficult. We analyze the limitations, and suggest approaches for future work in multi-view sketch-based modeling.
Immunological detection of proteins after isoelectric focusing in thin layer agarose gel: a specific application for the characterization of immunoglobulin diversity. (1983)

A simple and relatively rapid method was developed for the characterization of immunoglobulins from serum samples. After isoelectric focusing in a thin layer agarose gel proteins were transferred on to a nitrocellulose sheet by pressuring the focused gel against the sheet. A certain immunoglobulin class was stained on the sheet using alkaline phosphatase conjugated anti-immunoglobulins and the specific colour staining of the enzyme. The method allows the use of serum dilutions up to one thousand and conjugate dilutions up to two thousands. It was possible to strengthen the weak staining of antigens using a longer staining period and changing the substrate-dye solution without any background colorizing of the sheet. A specific application for the characterization of serum immunoglobulins of IgG class of a myeloma patient is presented.
Formal Conformance Testing of Systems with Refused Inputs and Forbidden Actions (2006)

The article introduces an extension of the well-known conformance relation ioco on labeled transition systems (LTS) with refused inputs and forbidden actions. This extension helps to apply the usual formal testing theory based on LTS models to incompletely specified systems, which are often met in practice. Another topic concerned in the article is compositional conformance. More precisely, we try to define a completion operation that turns any LTS into input-enabled one having the same set of ioco-conforming implementations. Such a completion enforces preservation of ioco conformance by parallel composition operation on LTSes.
Digiseis‐enhanced streamer surveys (DESS) in obstructed area: A case study of the Gulf of Mexico (1994)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1994Digiseis‐enhanced streamer surveys (DESS) in obstructed area: A case study of the Gulf of MexicoAuthors: Nicolae MoldoveanuDale AddessiJames T. LangKevin StiverMark ChangNicolae MoldoveanuGeco‐Prakla, Dale AddessiGeco‐Prakla, James T. LangGeco‐Prakla, Kevin StiverGeco‐Prakla, and Mark ChangGeco‐Praklahttps://doi.org/10.1190/1.1932027 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1932027FiguresReferencesRelatedDetailsCited byReferences29 April 20133-D symmetric samplingGijs J. O. Vermeer7 February 2012 | GEOPHYSICS, Vol. 63, No. 5 SEG Technical Program Expanded Abstracts 1994ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1994 Pages: 1679 publication data© 1994 Copyright © 1994 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Nicolae Moldoveanu, Dale Addessi, James T. Lang, Kevin Stiver, and Mark Chang, (1994), "Digiseis‐enhanced streamer surveys (DESS) in obstructed area: A case study of the Gulf of Mexico," SEG Technical Program Expanded Abstracts : 872-875. https://doi.org/10.1190/1.1932027 Plain-Language Summary PDF DownloadLoading ...
LTE relay backhaul design for sparsely-populated environments (2011)

In the latest release of the Long Term Evolution (LTE) standards, which will be completed in September 2011, it was decided to standardize relay nodes (RN) for the purpose of improving coverage. This makes RNs very suitable tools for increasing the coverage of low population density areas. The RN is a new type of node that was not previously standardized in 3GPP before and, as such, created new challenges. In particular, for RN, the backhaul link (connecting the enhanced Node B (eNB) and the RN) needs to be defined, and both uplink and downlink grants need to be conveyed to the RNs, either using existing channels (e.g., the Packet Dedicated Control Channel (PDCCH)), or a new channel (commonly referred to as the Relay-PDCCH (R-PDCCH)). In this paper, we discuss both channels for the Frequency Division Duplex (FDD) mode and show that using a R-PDCCH is a more efficient channel. In addition, several features are provided to ensure good performance for the R-PDCCH, such as robust use of frequency diversity by transmitting the R-PDCCH using Distributed Virtual Resource Blocks (DVRBs), or use of rate-matching to ensure optimal usage of the allocated resources for R-PDCCH transmission. This robustness is considered necessary to ensuring good reliability for sparsely populated areas.
Abstract 5502: Metrics other than potency reveal systematic variation in responses to cancer drugs (2014)

Abstract Most analyses of cellular responses to anti-cancer drugs focus on variation in potency (e.g. GI50 or IC50) under the assumption that potency is the most important difference between effective and ineffective drugs or sensitive and resistant cells. We took a multi-parametric approach involving analysis of additional features such as maximum effect (Emax), the slope of the dose-response curve (Hill Slope; HS), and the area under the curve (AUC). We found that a subset of these parameters varies in a systematic manner with cell line and another subset with drug class. For cell cycle inhibitors, Emax generally correlates with cell proliferation rate but this is not always true: Emax ∼ 0 for S-phase specific drugs such as cisplatin, carboplatin and oxaliplatin across multiple cell lines. For drugs targeting the Akt/PI3K/mTOR pathway the slope of the dose-response curve is unusually shallow (HS &amp;lt;&amp;lt; 1). Classical pharmacology has no ready explanation for this phenomenon but single-cell analysis showed that it correlated with significant and heritable cell-to-cell variability in the extent of target inhibition. We conclude that parameters other than potency should be considered in the comparative analysis of drug response, particularly at clinically relevant concentrations near and above IC50. Citation Format: Mohammad Fallahi-Sichani, Saman Honarnejad, Laura M. Heiser, Joe W. Gray, Peter K. Sorger. Metrics other than potency reveal systematic variation in responses to cancer drugs. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5502. doi:10.1158/1538-7445.AM2014-5502
Learning filter banks within a deep neural network framework (2013)

Mel-filter banks are commonly used in speech recognition, as they are motivated from theory related to speech production and perception. While features derived from mel-filter banks are quite popular, we argue that this filter bank is not really an appropriate choice as it is not learned for the objective at hand, i.e. speech recognition. In this paper, we explore replacing the filter bank with a filter bank layer that is learned jointly with the rest of a deep neural network. Thus, the filter bank is learned to minimize cross-entropy, which is more closely tied to the speech recognition objective. On a 50-hour English Broadcast News task, we show that we can achieve a 5% relative improvement in word error rate (WER) using the filter bank learning approach, compared to having a fixed set of filters.
Curcumin Reduces Angiotensin II-mediated Cardiomyocyte Growth via LOX-1 Inhibition (2010)

Curcumin attenuates Ang II-mediated cardiomyocyte growth by inhibiting LOX-1 and AT1R expression and suppressing the heightened intracellular redox state.
Metamagnetics for Visible Wavelengths (491 – 754 nm) (2007)

We designed, fabricated and experimentally validated a representative number of periodic arrays of magnetically resonant silver nanostrips. Our studies confirmed that the coupled-strip design can provide controllable magnetic responses in the entire visible range.
Non Invasive Evaluation of Cardiac Dysfunction in β‐thalassemic Mice (2008)

Beta‐thalassemia is a genetic hematological disorder characterized by mutations of the hemoglobin gene causing total or partial decrease of the β‐globin chain production. This disease leads to a chronic hemolytic anemia, cardiac complications and blood circulatory problems such as transitory ischemic attacks, thromboembolic events and microcirculatory obstructions. Our objective is to study and dissect the molecular physiologic mechanism of cardiovascular dysfunction in β‐thalassemia. We have generated a murine model of β‐thalassemia major primarily for the investigation of the cardiovascular physiology. Left ventricular morphology and function were assessed by echocardiography in 13.5‐month‐old β‐thalassemic mice and age matched controls. The left ventricular mass index and total peripheral vascular resistance were significantly increased ( p &lt; 0.05 and p &lt; 0.01, respectively) in β‐thalassemic mice compared to wildtype controls. Furthermore, fractional shortening and cardiac output index were significantly decreased ( p &lt; 0.01) in β‐thalassemic mice compared to age matched controls. Thus, these data in β‐thalassemic mice showed left ventricular remodeling by dilatation and hypertrophy that likely play a key role in cardiac dysfunction. This work was supported by the NIH (#RO1HL078655), CIHR (#CMI 72323), HSFC (#PG‐05‐0313).
Revue bibliographique: Catalogue of Discomycetes referred to the genera Helotium Pers. and Hymenoscyphus Gray (2015)

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Integrated Capture, Concentration, Polymerase Chain Reaction, and Capillary Electrophoretic Analysis of Pathogens on a Chip (2009)

A laboratory-on-a-chip system for pathogen detection is presented that integrates cell preconcentration, purification, polymerase chain reaction (PCR), and capillary electrophoretic (CE) analysis. The microdevice is composed of micropumps and valves, a cell capture structure, a 100 nL PCR reactor, and a 5 cm long CE column for amplicon separation. Sample volumes ranging from 10 to 100 microL are introduced and driven through a fluidized bed of magnetically constrained immunomagnetic beads where the target cells are captured. After cell capture, beads are transferred using the on-chip pumps to the PCR reactor for DNA amplification. The resulting PCR products are electrophoretically injected onto the CE column for separation and detection of Escherichia coli K12 and E. coli O157 targets. A detection limit of 0.2 cfu/microL is achieved using the E. coli O157 target and an input volume of 50 microL. Finally, the sensitive detection of E. coli O157 in the presence of K12 at a ratio of 1:1000 illustrates the capability of our system to identify target cells in a high commensal background. This cell capture-PCR-CE microsystem is a significant advance in the development of rapid, sensitive, and specific laboratory-on-a-chip devices for pathogen detection.
Modification of an ITO anode with a hole-transporting SAM for improved OLED device characteristics (2002)

Modification of inorganic electrodes has attracted much attention in the study of organic semiconductor devices. An ethoxysilane functionalized hole-transporting triphenylamine (TPA–CONH–silane) was synthesized and was self-assembled to form a monolayer on an indium tin oxide (ITO) anode. The modified surface was characterized by water contact angle, X-ray photoelectron spectroscopy (XPS), ellipsometry and atomic force microscopy (AFM). The increase in surface work function is expected to facilitate hole injection from the ITO anode. To investigate the effect of a self-assembled monolayer (SAM) on the characteristics an organic light-emitting diode (OLED), a typical OLED device [SAM-modified ITO/TPD (50 nm)/Alq3 (60 nm)/LiF (1 nm)/Al (70 nm)] was fabricated. The SAM-modified device could endure a higher current and showed a much higher luminance (6300 cd m−2) than the bare ITO device (2700 cd m−2). The external quantum efficiency was also shown to improve as a result of the presence of the SAM. In addition to these device characteristics, a study of the TPD film morphology revealed an enhanced thermal stability for the SAM-modified device. The variation of the terminal group of the SAM and possible further optimization of SAM-modified OLEDs is under investigation.
Two-level optimization approach with accelerated proximal gradient for objective measures in sparse speech reconstruction (2021)

&lt;p style='text-indent:20px;'&gt;Compressive speech enhancement makes use of the sparseness of speech and the non-sparseness of noise in time-frequency representation to perform speech enhancement. However, reconstructing the sparsest output may not necessarily translate to a good enhanced speech signal as speech distortion may be at risk. This paper proposes a two level optimization approach to incorporate objective quality measures in compressive speech enhancement. The proposed method combines the accelerated proximal gradient approach and a global one dimensional optimization method to solve the sparse reconstruction. By incorporating objective quality measures in the optimization process, the reconstructed output is not only sparse but also maintains the highest objective quality score possible. In other words, the sparse speech reconstruction process is now quality sparse speech reconstruction. Experimental results in a compressive speech enhancement consistently show score improvement in objectives measures in different noisy environments compared to the non-optimized method. Additionally, the proposed optimization yields a higher convergence rate with a lower computational complexity compared to the existing methods.&lt;/p&gt;
<title>Relationship between an EUV source and the performance of an EUV lithographic system</title> (2000)

The light source is a critical factor when Extreme Ultra Violet Lithography (EUVL) is used. This paper shows the link between the light source and the customer's requirements. These are: Throughput, Cost of Ownership (CoO) and imaging quality (e.g. CD uniformity). Also shown is how customer requirements dictate the necessary performance specifications for light sources. To be competitive with other New Generation Lithography technologies, EUVL tools should show a potential for high throughput. This puts a high requirement on the collectable in-band power produced by an EUV source. CD control requirements, together with restrictions of reflective optics, are discussed. This means that the pulse-to-pulse repeatability, the spatial stability control and the repetition rates, must be substantially better than those of current optical systems. It is essential, in the early stages of the development of potential light sources, to understand the source limitations. It is also essential to see the way the light source or the total source/lithographic system could be improved, in the development time, to meet the lithography tool requirements. Although there are no light sources currently under development that comply with the requirements for an EUVL production tool, future improvement in the performance of light sources seems possible. This paper shows detailed analyses of the way to meet (beta) and production tool requirements, including the increase in repetition rate, for all of the sources. The decrease in energy per pulse will also be discussed. The performance requirements for the light source for the first lithographic tool, together with the timeline for its choice, will be shown.