gebhart/patrepeval huggingface dataset:
Multifidelity Modeling Framework for Bayesian-Based Multidisciplinary Aircraft Design Optimization (2012)

Complex aircraft systems have properties that are both multidisciplinary and highly interdependent. Multidisciplinary modeling of these complex systems requires that each discipline inform and be informed by the other disciplines simultaneously. Furthermore, multifidelity modeling, where any single discipline model of varying fidelity may be used interchangeably with the other discipline models of non-similar fidelity, requires that discipline models of all fidelities be capable of interacting with the multidisciplinary system in the same way. This paper describes a Bayesian-based multifidelity design optimization framework for a medium-altitude remotely piloted aircraft. The various disciplines and corresponding fidelities represented in the design problem, structures, propulsion, and aerodynamics, are briefly described in their context for interaction with the framework. Finally, the results of the system design tools at varying fidelities are described as it pertains to aircraft design and optimization.
Cord Blood CD4+CD25+ Derived T Regulatory Cell Lines Express FoxP3 Protein and Manifest Potent Suppressor Function. (2004)

Abstract CD4+CD25+ T regulatory (Treg) cells have been shown to critically regulate self and more recently allograft tolerance in mice. Studies of human Treg have been hindered by the presence of CD25-dim conventional T cells that copurify during Treg isolation. We compared adult and cord blood sources for Treg, with the hypothesis that cord blood should lack significant numbers of memory cells or environmentally reactive T cells. We found that cord blood was a superior source for Treg isolation compared to adult blood. CD4+CD25+ cells were readily purified, and generated cell lines that consistently exhibited potent suppressor activity, with &gt;95% suppression of allogeneic MLR (29/30 donors). The cells could markedly suppress an allo-MLR at a 1/16-1/32 suppressor/responder cell ratio. The cultured Treg cells blocked cytokine accumulation in MLR, with a less robust inhibition of chemokine production. Cultured Treg uniformly expressed CD25, CD62L, CCR7, CD27, and intracellular CTLA4. Upon re-stimulation with anti-CD3/CD28 beads, the cultured Treg produced minimal cytokines (IL2, IFN-gamma, and IL10), and preferentially expressed TGF-beta latency associated protein on the cell surface, while conventional CD4+CD25− derived cell lines did not. Cytokine production however, could be largely restored by stimulation with PMA/ionomycin. Abundant FoxP3 mRNA was detected in fresh, cultured, and anti-CD3/CD28 bead restimulated CD4+CD25+ cells (approximately 2–4 fold less than cyclophillin A). Low amounts of FoxP3 mRNA were present in fresh CD25− cells, and they increased 32 fold on culture. However, FoxP3 protein, as assessed by western blot, was specifically expressed in the CD25+ derived cell lines, and was not detected in the CD25− derived cell lines. Restimulation with anti-CD3/CD28 beads led to increased expression of FoxP3 protein in CD25+ derived cell lines, but not in CD25− derived cell lines. Cord blood derived cultured suppressor cells were not cytolytic in chromium release assays, and mediated suppression of alloreactivity that was cell contact dependent and predominantly independent of IL10 and TGF-beta. Antibodies to GITR, GITR-L, OX40, OX40-L, CTLA4, and PD1 did not significantly affect suppression of the culture activated Treg cells. These results demonstrate virtually pure populations of potent suppressor cells can be cultured from cord blood, and these cell lines form an ideal model system for the evaluation of suppressor cell biology and mechanisms of action.
Linear Free Energy Analysis of Hydrogen Bonding in Proteins (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLinear Free Energy Analysis of Hydrogen Bonding in ProteinsJon S. Thorson, Eli Chapman, Elizabeth C. Murphy, Peter G. Schultz, and J. Kevin JudiceCite this: J. Am. Chem. Soc. 1995, 117, 3, 1157–1158Publication Date (Print):January 1, 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/ja00108a044https://doi.org/10.1021/ja00108a044research-articleACS PublicationsRequest reuse permissionsArticle Views473Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Conformation of Side Chain Nematic Polymers in Nematic Solutions: a Small-Angle X-Ray Scattering Study: SAXS (1986)

Using a small-angle x-ray scattering technique, we have determined the sizes of side chain mesomorphic polymers diluted in a low-molecular-weight liquid crystal, respectively, parallel (R∥) and perpendicular (R⊥) to the director of the nematic medium (n0). We found a significant difference between the two values, with R∥ > R⊥. These results are a direct proof of the anisotropy of the polymer conformation in a nematic medium; they permit to check the validity of the interpretation that we have previously given for the hydrodynamical behaviour of such solutions.
TI-POOLING: transformation-invariant pooling for feature learning in\n Convolutional Neural Networks (2016)

In this paper we present a deep neural network topology that incorporates a\nsimple to implement transformation invariant pooling operator (TI-POOLING).\nThis operator is able to efficiently handle prior knowledge on nuisance\nvariations in the data, such as rotation or scale changes. Most current methods\nusually make use of dataset augmentation to address this issue, but this\nrequires larger number of model parameters and more training data, and results\nin significantly increased training time and larger chance of under- or\noverfitting. The main reason for these drawbacks is that the learned model\nneeds to capture adequate features for all the possible transformations of the\ninput. On the other hand, we formulate features in convolutional neural\nnetworks to be transformation-invariant. We achieve that using parallel siamese\narchitectures for the considered transformation set and applying the TI-POOLING\noperator on their outputs before the fully-connected layers. We show that this\ntopology internally finds the most optimal "canonical" instance of the input\nimage for training and therefore limits the redundancy in learned features.\nThis more efficient use of training data results in better performance on\npopular benchmark datasets with smaller number of parameters when comparing to\nstandard convolutional neural networks with dataset augmentation and to other\nbaselines.\n
Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin (2016)

<i>Clostridium difficile</i> binary toxin (CDT) is an ADP-ribosyltransferase which is linked to enhanced pathogenesis of <i>C. difficile</i> strains. CDT has dual function: domain <i>a</i> (CDTa) catalyses the ADP-ribosylation of actin (enzymatic component), whereas domain <i>b</i> (CDTb) transports CDTa into the cytosol (transport component). Understanding the molecular mechanism of CDT is necessary to assess its role in <i>C. difficile</i> infection. Identifying amino acids that are essential to CDTa function may aid drug inhibitor design to control the severity of <i>C. difficile</i> infections. Here we report mutations of key catalytic residues within CDTa and their effect on CDT cytotoxicity. Rather than an all-or-nothing response, activity of CDTa mutants vary with the type of amino acid substitution; S345A retains cytotoxicity whereas S345Y was sufficient to render CDT non-cytotoxic. Thus CDTa cytotoxicity levels are directly linked to ADP-ribosyltransferase activity.
Antibodies for Transplantation (2000)

The use of antibodies in transplantation has become a clinical reality. Antibodies have been used to both dampen the recipient’s immune response and to obscure the immunogenicity of the donor graft. Traditionally, antibodies have been administered to the transplant recipient to transiently inactivate the host’s T cells, the lymphocytes responsible for recognizing and attacking foreign proteins, cells, and tissues. Antibodies can also be used to eliminate any highly immunogenic passenger cells from a donor graft prior to transplantation, and antibodies can mask or conceal antigens present on donor cells that might trigger rejection.
Graphene nanoplatelet and Graphene oxide functionalization of face mask materials inhibits infectivity of trapped SARS-CoV-2 (2020)

Abstract Recent advancements in bidimensional nanoparticles such as Graphene nanoplatelets (G) and the derivative Graphene oxide (GO) have the potential to meet the need for highly functional personal protective equipment (PPE) that confers increased protection against SARS-CoV-2 infection and the spread COVID-19. The ability of G and GO to interact with and bind microorganisms as well as RNA and DNA provides an opportunity to develop engineered textiles for use in PPE. The face masks widely used in health care and other high-risk settings for COVID transmission provide only a physical barrier that decreases likelihood of infection and do not inactivate the virus. Here, we show pre-incubation of viral particles with free GO inhibits SARS-CoV-2 infection of VERO cells. Highly relevant to PPE materials, when either polyurethane or cotton material was loaded with G or GO and culture medium containing SARS-CoV-2 viral particles either filtered through or incubated with the functionalized materials, the infectivity of the medium was nearly completely inhibited. The findings presented here constitute an important nanomaterials-based strategy to significantly increase face mask and other PPE efficacy in protection against the SARS-CoV-2 virus and COVID-19 that may be applicable to additional anti-SARS-CoV-2 measures including water filtration, air purification, and diagnostics. One Sentence Summary Cotton and polyurethane materials functionalized with bidimensional Graphene nanoplatelets trap SARS-CoV-2 and have the potential to reduce spread of COVID-19.
Spintronic memristors for neuromorphic circuits based on the angular variation of tunnel magnetoresistance (2021)

In this study, a new type of compact magnetic memristor is demonstrated. It is based on the variation of the conductivity of a nano-sized magnetic tunnel junction as a function of the angle between the in-plane reference layer magnetization and a free layer exhibiting an isotropic in-plane coercivity. The free layer magnetization is rotated by two spin transfer torque contributions: one originating from the in-plane magnetized reference layer and the other one from an additional perpendicular polarizer integrated in the stack. Thanks to a proper tuning of the relative influence of these two torques, the magnetization of the free layer can be rotated step by step clockwise or anticlockwise in a range of angle between 0° (parallel configuration) and 180° (anti-parallel configuration) by sending pulses of current through the stack, of one or opposite polarity. The amplitude of the rotation steps and therefore of the conductance variations depends on the pulse amplitude and duration. In this way, we achieve monotonous variations of the resistance with the voltage polarity through the application of pulses in the ns range. We also retrieve the analytical expression of critical current density which is found to be in good agreement with the experimental results. The thermal stability of the intermediate resistance levels and the role of Joule heating are also discussed.
Effect of Climate Change on Reliability of Rainwater Harvesting Systems for Kabarole District, Uganda (2018)

This paper assesses the effect of climate change on reliability of rainwater harvesting systems for Kabarole district, Uganda, as predicted by 6 best performing global circulation models (GCMs). A daily water balance model was used to simulate the performance of a rainwater harvesting system using historical daily rainfall data for 20 years. The GCMs used to generate daily rainfall projections for 2025–2055 and 2060–2090 periods included; ACCESS1-0, BCC-CSM-1-M, CNRM-CM5, HADGEM2-CC, HADGEM2-ES and MIROC5. Analysis was based on the Ugandan weather seasons which included March, April, May (MAM) and September, October, November (SON) rain seasons in addition to December, January, February (DJF) and June, July, August (JJA) dry seasons. While an increase in reliability is predicted for the SON season, the worst-case scenario is projected during the MAM season with a reliability reduction of over 40% for the 2055–2090 period. This corresponds to a 27% reduction in water security for the same period. The DJF season is also expected to experience reduced water security by 1–8% for 2025–2055 and 2060–2090 with a 0.5 m3 tank size. Therefore, some form of extra harvesting surface and increased tank size will be required to maintain 80% systems reliability considering climate change.
Hypotensive mechanism of potassium supplementation in salt-loaded patients with essential hypertension. (1985)

To investigate the hypotensive mechanism of potassium supplementation, blood pressure responses and hormonal changes were measured during KCl supplementation in salt-loaded patients with essential hypertension. Ten patients with essential hypertension were placed on low sodium intake, high sodium intake, and high sodium intake with KCl supplementation. Blood pressure increased during NaCl loading and decreased during KCl supplementation. The levels of urinary sodium and fractional sodium excretion increased after KCl supplementation. Reduction in blood pressure after KCl supplementation was correlated with an increase in blood pressure after NaCl supplementation, i.e., potassium sensitivity and sodium sensitivity were correlated. Plasma PGE2 and norepinephrine increased after KCl loading. Increases in plasma PGE2 were correlated with a reduction of blood pressure by KCl. These results indicate that natriuresis and hypotensive action of KCl are associated with increased PGE2 production, and the sympathetic nerve activity suggests a compensatory increase for the decrease in blood pressure.
DEN ÖKADE E-HANDELNS PÅVERKAN PÅ FYSISKA BUTIKER : En studie inriktad på kundrelationer inom elektronikbranschen (2017)

DEN OKADE E-HANDELNS PAVERKAN PA FYSISKA BUTIKER : En studie inriktad pa kundrelationer inom elektronikbranschen
Proteomic Identification of Potential Target Proteins of Cathepsin W for Its Development as a Drug Target for Influenza (2022)

Influenza A virus (IAV) coopts numerous host factors for efficient replication. The cysteine protease cathepsin W (CTSW) has been identified as one host factor required for IAV entry, specifically for the escape of IAVs from late endosomes. However, the substrate specificity of CTSW and the proviral mechanism are thus far unknown. Here, we show that intracellular but not secreted CTSW promotes viral entry. We reveal 79 potential direct and 31 potential indirect cellular target proteins of CTSW using the high-throughput proteomic approach terminal amine isotopic labeling of substrates (TAILS) and determine the cleavage motif shared by the substrates of CTSW. Subsequent integration with data from RNA interference (RNAi) screens for IAV host factors uncovers first insights into the proviral function of CTSW. Notably, CTSW-deficient mice display a 25% increase in survival and a delay in mortality compared to wild-type mice upon IAV infection. Altogether, these findings support the development of drugs targeting CTSW as novel host-directed antiviral therapies. <b>IMPORTANCE</b> Influenza viruses are respiratory pathogens and pose a constant threat to human health. Although antiviral drugs are available for influenza, the emergence and spread of drug-resistant viruses is cause for concern. Therefore, the development of new antivirals with lower chances of their target viruses acquiring resistance is urgently needed to reduce the high morbidity and mortality caused by influenza. Promising alternatives to drugs targeting viral proteins are those directed against host factors required for viral replication. The cysteine protease cathepsin W (CTSW) is an important host factor for IAV replication, and its proteolytic activity is required for fusion of viral and endosomal membranes. In this work, we identify a number of hitherto unknown CTSW substrates, providing new insights into virus-host interactions, and reveal that CTSW might also play a proviral role in an <i>in vivo</i> model. These results support the development of CTSW as a drug target for next-generation antivirals against influenza.
Engineering of a redox protein for DNA-directed assembly (2011)

Engineered enzyme conjugate of the small laccase enzyme from Streptomyces coelicolor and zinc finger DNA binding domain from Zif268 is demonstrated to bind double stranded DNA in a site specific manner while retaining enzymatic activity.
High Performance Silicon-Based Negative Electrodes for Li-Ion Batteries (2013)

Abstract not Available.
Search forWBoson Pair Production inpp¯Collisions ats=1.8TeV (1995)

The results of a search for $W$ boson pair production in $p\overline{p}$ collisions at $\sqrt{s}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}1.8\mathrm{TeV}$ with subsequent decay to dilepton ( $e\ensuremath{\mu},ee$, and $\ensuremath{\mu}\ensuremath{\mu}$) channels are presented. One event is observed with an expected background of $0.56\ifmmode\pm\else\textpm\fi{}0.13$ events with an integrated luminosity of approximately $14{\mathrm{pb}}^{\ensuremath{-}1}$. Assuming equal strengths for the $\mathrm{WWZ}$ and $\mathrm{WW}\ensuremath{\gamma}$ gauge boson coupling parameters $\ensuremath{\kappa}$ and $\ensuremath{\lambda}$, limits on the $\mathrm{CP}$-conserving anomalous coupling constants are $\ensuremath{-}2.6&lt;\ensuremath{\Delta}\ensuremath{\kappa}&lt;2.8$ and $\ensuremath{-}2.1&lt;\ensuremath{\lambda}&lt;2.1$ at the 95% confidence level.
On the optical performance of composite structures of graphene and photonic crystals at infrared wavelengths (2017)

This work reports on a study regarding the optical performance of composite structures consisting of graphene and photonic crystals at infrared wavelengths. In the composite structures, single and/or multi-layer graphene are placed in between the alternating dielectric materials of the photonic crystals. The optical properties of the composite structures, including the light transmittance and reflectance, are numerically simulated in the infrared wavelength range from 1 to 100 μm, by varying the parameters associated with the graphene. The results reveal a band-gap feature below 6 μm, and a switch-like characteristics above 6 μm. The results also demonstrate that the optical properties of the composite structures can be tuned in the infrared regime, by adjusting the graphene parameters, including the Fermi energy levels and the layer numbers. Based on the optical performance revealed in this study, we suggest that the composite structures comprised of graphene and photonic crystals be implemented in future designs of plasmonic tuning devices at infrared wavelengths.
ChemInform Abstract: 1,3‐Diarylcycloalkanopyrazoles and Diphenyl Hydrazides as Selective Inhibitors of Cyclooxygenase‐2. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Occupational dermatoses in the food industry. (1985)

The occurrence of skin diseases in employees engaged in the food industry has been investigated by means of an epidemiological cross-sectional study. Of the 1052 workers in a large factory in Turku (Finland), 17% reported a current skin disease. Occupational eczema was diagnosed in 8,5% of the 541 female employees examined in detail. It was twice as common among those handling fish, meat and vegetables or making "instant" food as among those making confectionery. Hand eczema was present in 15% of the 196 workers handling food, in 8,5% of the 259 confectioners and in 6% of the 86 office employees. History of atopic dermatitis could be revealed in 30% and history of asthma or hay fever without dermatitis in 15% of the employees with current hand eczema.
An evaluation of the sustainability of some biofuel feedstocks. (2013)

The sustainability of a biofuel feedstock must be viewed holistically on three aspectseconomic, environment and social. A single biofuel which satisfies all these aspects completely does not exist. Based on this study, among the first generation biofuels which support today's biofuel programmes, palm oil biodiesel is seen to be a very highly sustainable biofuel feedstock, exceeding the other biofuel feedstocks, including corn, rapeseed and soya. In addition, palm oil production for food also leaves behind a large source of biomass wastes which can potentially be used to produce second generation biofuels and avert the food-fuel quandary.
Relationship between single quantum-dot intermittency and fluorescence intensity decays from collections of dots (2004)

We show that the slow dynamics of the fluorescence from a collection of colloidal quantum dots and the intermittency observed in single quantum dots are intimately related. This system illustrates the importance of uncovering dynamical behavior at the microscopic level for a proper understanding of ensemble phenomenology. We propose a model that introduces lower and upper bounds to the on- and off-time power-law distributions in single-nanocrystal quantum-dot (QD) fluorescence intermittency statistics. We use Monte Carlo simulations and analytical forms to quantitatively connect this single QD model to the fluorescence intensity decay to a steady state that is observed in collections of QD's. Inversely, we also show that experiments on collections of QD's can be used to directly obtain upper bounds to the single-QD fluorescence intermittency power-law statistics.
Using dynamically created decision-making organizations (holarchies) to plan, commit, and execute control tasks in a chilled water system (2004)

A multi-agent architecture to automate complex industrial systems is described. The multi-agent system is created with artificial social behaviors to enable cooperation among the agents. Agents organize their respective views about the system to react to changes and to discover system capabilities. We explore the implications of using agent technology in the design and operation of a chilled water system. Our aim is to contribute with a set of guidelines on how to build autonomous agents for industrial automation.
Rapid controlled movement through virtual 3D workspaces (videotape) (1991)

No abstract available.