gebhart/patrepeval huggingface dataset:
Lanreotide promotes apoptosis and is not radioprotective in GH3 cells (2009)

Somatostatin analogs are a mainstay of medical therapy in patients with GH producing human pituitary tumors, and it has been suggested that somatostatin analogs may be radioprotective. We utilized GH secreting rat GH3 cells to investigate whether a somatostatin analog may limit the effects of radiation on proliferation and apoptosis in vitro and on tumor growth in vivo. Treatment with lanreotide alone at doses of either 100 or 1000 nM for 48 h reduced clonogenic survival by 5-10%. Radiation alone produced a dose-dependent survival curve with a SF2 of 48-55%, and lanreotide had no effect on this curve. The addition of lanreotide resulted in a 23% increase in the proportion of apoptotic sub-G1 cells following irradiation (P<0.01). In a mouse GH3 tumor xenograft model, lanreotide 10 mg/kg moderately inhibited the growth of GH3 tumors, with a 4x tumor growth delay (TGD) time that ranged from 4.5 to 8.3 days. Fractionated local tumor radiation alone significantly inhibited tumor growth and produced a TGD of 35.1+/-5.7 days for 250 cGy fractions. The combination of lanreotide, either antecedent to or concurrent, with radiation of 250, 200 or 150 cGy/fraction for 5 days inhibited tumor growth and produced the TGD times that were similar to radiation alone (P>0.05). Pretreatment with lanreotide had the most significant radiosensitizing effect. These studies demonstrate that the somatostatin analog lanreotide is not radioprotective in GH3 cells, and further studies are necessary to determine the impact of lanreotide on apoptosis.
Insulin-like growth factors stimulate growth and L-cysteine uptake by the intestinal parasite Giardia lamblia. (1994)

Giardia lamblia, a parasitic protozoan responsible for diarrhea and malabsorption in humans, grows axenically only in media that contain serum and a high concentration of L-cysteine. During our attempts to grow Giardia in the absence of serum, we found that: (a) human insulin-like growth factors (especially IGF-II), but not insulin, promote the growth and L-cysteine uptake by G. lamblia trophozoites; (b) the growth stimulation was inhibited by alpha IR3, an anti-type 1 IGF receptor monoclonal antibody, but an anti-type 2 IGF receptor antibody had no effect; and (c) IGFs act on Giardia through a type 1 IGF receptor-like protein, which can bind IGF-II with higher affinity than IGF-I, and most likely possesses intrinsic phosphotyrosine kinase activity.
Efficient Multi-Domain Schemes for Large Quantum Systems’ Calculations (2021)

We demonstrate a parallel and efficient mutli-domain scheme for Density Functional Theory (DFT) calculations of large molecular systems. The system is divided into sub-domains and the electrostatic potential produced by the charge density of each subdomain is calculated in a parallel manner. We show that our scheme leads to a linear scaling (instead of cubic) for the calculation time while keeping the same accuracy. This is demonstrated for a couple of systems with two molecules.
Histone Deacetylase 6 Knockout Mice Exhibit Higher Susceptibility to Influenza A Virus Infection (2020)

The host innate defence against influenza virus infection is an intricate system with a plethora of antiviral factors involved. We have identified host histone deacetylase 6 (HDAC6) as an anti-influenza virus factor in cultured cells. Consistent with this, we report herein that HDAC6 knockout (KO) mice are more susceptible to influenza virus A/PR/8/1934 (H1N1) infection than their wild type (WT) counterparts. The KO mice lost weight faster than the WT mice and, unlike WT mice, could not recover their original body weight. Consequently, more KO mice succumbed to infection, which corresponded with higher lung viral loads. Conversely, the expression of the critical innate antiviral response genes interferon alpha/beta, CD80, CXCL10 and IL15 was significantly downregulated in KO mouse lungs compared to WT mouse lungs. These data are consistent with the known function of HDAC6 of de-acetylating the retinoic acid inducible gene-I (RIG-I) and activating the host innate antiviral response cascade. Loss of HDAC6 thus leads to a blunted innate response and increased susceptibility of mice to influenza A virus infection.
Optical anisotropy in single InAs/InP quantum dot and quantum rod nanowires (2015)

October 26-30, 2015
Localization of full-length recombinant human proteoglycan-4 in commercial contact lenses using confocal microscopy (2019)

The aim of this study was to determine the sorption location of full-length recombinant human proteoglycan 4 (rhPRG4) tagged with fluorescein isothiocyanate (FITC) to four silicone hydrogel contact lenses [balafilcon A (PureVision, Bausch + Lomb), senofilcon A (Acuvue Oasys, Johnson & Johnson), comfilcon A (Biofinity, CooperVision), lotrafilcon B (Air Optix, Alcon)] and one conventional hydrogel lens [etafilcon A (Acuvue 2, Johnson & Johnson)], using confocal laser scanning microscopy (CLSM). Lenses (<i>n</i> = 3 each) were incubated under two conditions: (1) FITC-rhPRG4 solution at 300 μg/mL and (2) phosphate-buffered saline, for 1 h at 37 °C in darkness with gentle shaking. The central 4 mm of each lens was removed and viewed with the Zeiss 510 CLSM using an argon laser at 488 nm (FITC excitation 495 nm, emission 521 nm). Depth scans were taken at 1 μm intervals to a maximum depth of 100 μm. All lens materials demonstrated sorption of rhPRG4. Both senofilcon A and balafilcon A revealed FITC-rhPRG4 penetration into the bulk of the lens, generally favoring the surface. rhPRG4 was observed exclusively on the surface of lotrafilcon B, with no presence within the bulk of the lens. rhPRG4 was evenly distributed throughout the bulk of the lens, as well as on the surface, for comfilcon A and etafilcon A. The sorption profile of FITC-rhPRG4 was successfully visualized using CLSM in various contact lens materials. The polymer composition, surface treatment and pore size of the material can influence the sorption of rhPRG4.
Fashion apparel detection: The role of deep convolutional neural network and pose-dependent priors (2016)

In this work, we propose and address a new computer vision task, which we call fashion item detection, where the aim is to detect various fashion items a person in the image is wearing or carrying. The types of fashion items we consider in this work include hat, glasses, bag, pants, shoes and so on. The detection of fashion items can be an important first step of various e-commerce applications for fashion industry. Our method is based on state-of-the-art object detection method pipeline which combines object proposal methods with a Deep Convolutional Neural Network. Since the locations of fashion items are in strong correlation with the locations of body joints positions, we incorporate contextual information from body poses in order to improve the detection performance. Through the experiments, we demonstrate the effectiveness of the proposed method.
Microencapsulated human bone marrow cultures: A potential culture system for the clonal outgrowth of hematopoietic progenitor cells (1994)

Currently the most successful methods for culturing human hematopoietic cells employ some form of perfused bioreactor system. However, these systems do not permit the clonal outgrowth of single progenitor cells. Therefore, we have investigated the use of alginate-poly-L-lysine microencapsulation of human bone marrow, combined with rapid medium exchange, as a system that may overcome this limitation for the purpose of studying the kinetics of progenitor cell growth. We report that a 12 to 24-fold multilineage expansion of adult human bone marrow cells was achieved in about 16 to 19 days with this system and that visually identifiable colonies within the capsules were responsible for the increase in cell number. The colonies that represented the majority of cell growth originated from cells that appeared to be present in a frequency of about 1 in 4000 in the encapsulated cell population. These colonies were predominantly granulocytic and contained greater than 40,000 cells each. Large erythroid colonies were also present in the capsules, and they often contained over 10,000 cells each. Time profiles of the erythroid progenitor cell density over time were obtained. Burst-forming units erythroid (BFU-E) peaked around day 5, and the number of morphologically identifiable erythroid cells (erythroblasts through reticulocytes) peaked on day 12. We also report the existence of a critical inoculum density and how growth was improved with the use of conditioned medium derived from a microcapsule culture initiated above the critical inoculum density. Taken together, these results suggest that microencapsulation of human hematopoietic cells allows for outgrowth of progenitor, and possible preprogenitor, cells and could serve as a novel culture system for monitoring the growth and differentiation kinetics of these cells.
Effect of potato composition on drum dryer capacity. (1990)

A model for predicting the production capacity of a single drum dryer for potato flakes was developed. The model uses process parameters for drum speed, steam pressure and number of spreader rolls. It also includes the texture of the raw potato, degree of cooking, starch content of the raw potato and the bulk density of the dried raw potato. The model accounted for variation observed due to cultivar and production year
I/O Translation Layer Technology for High-performance and Compatibility Using New Memory (2015)

The rapid advancement of computing technology has triggered the need for fast data I/O processing and high-performance storage technology. Next generation memory technology, which we refer to as new memory, is anticipated to be used for high-performance storage as they have excellent characteristics as a storage device with non-volatility and latency close to DRAM. This research proposes NTL (New memory Translation layer) as a technology to make use of new memory as storage. With the addition of NTL, conventional I/O is served with existing mature disk-based file systems providing compatibility, while new memory I/O is serviced through the NTL to take advantage of the byte-addressability feature of new memory. In this paper, we describe the design of NTL and provide experiment measurement results that show that our design will bring performance benefits.
Angularly-Resolved ExB Probe Spectra in the Plume of a 6-kW Hall Thruster (2008)

Peer Reviewed
Re: Uric Acid Stones in the Urinary Bladder of Aryl Hydrocarbon Receptor (AhR) Knockout Mice (2012)

No AccessJournal of UrologyInvestigative Urology1 Sep 2012Re: Uric Acid Stones in the Urinary Bladder of Aryl Hydrocarbon Receptor (AhR) Knockout Mice Anthony AtalaM.D. Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.05.040AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Uric Acid Stones in the Urinary Bladder of Aryl Hydrocarbon Receptor (AhR) Knockout Mice." The Journal of Urology, 188(3), p. 1042 © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 188Issue 3September 2012Page: 1042 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Physical Layer Performance (2007)

This chapter contains sections titled: Introduction Cell Coverage Downlink Cell Capacity Capacity Trials 3GPP Performance Requirements Performance Enhancements References
Structure development in cyanate ester polymerization (1997)

We present results on the product distribution obtained from the polymerization of the dicyanate monomer of bisphenol A carried out under different reaction conditions. Small quantities of side-products were observed using both size exclusion chromatography and high-pressure liquid chromatography for samples polymerized under an inert atmosphere. Despite the presence of side-products, the oligomer distribution from SEC, after correcting for differences in refractive index, was found to agree well with random branching predictions. Results from HPLC also confirm good agreement with the theoretical prediction. Furthermore, a gel conversion of approximately 0·51(-0·01, +0·03) was measured for the inert atmosphere product, which is within experimental error of the ideal value of 0·50. The monomer content of a polymerization carried out open to the atmosphere, however, showed significant disagreement with theory. ©1997 SCI
The PPAR‐Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects (2007)

Historically, platelets were viewed as simple anucleate cells responsible for initiating thrombosis and maintaining hemostasis, but clearly they are also key mediators of inflammation and immune cell activation. An emerging body of evidence links platelet function and thrombosis to vascular inflammation. peroxisome proliferator-activated receptors (PPARs) play a major role in modulating inflammation and, interestingly, PPARs (PPARbeta/delta and PPARgamma) were recently identified in platelets. Additionally, PPAR agonists attenuate platelet activation; an important discovery for two reasons. First, activated platelets are formidable antagonists that initiate and prolong a cascade of events that contribute to cardiovascular disease (CVD) progression. Dampening platelet release of proinflammatory mediators, including CD40 ligand (CD40L, CD154), is essential to hinder this cascade. Second, understanding the biologic importance of platelet PPARs and the mechanism(s) by which PPARs regulate platelet activation will be imperative in designing therapeutic strategies lacking the deleterious or unwanted side effects of current treatment options.
Minimally Supervised Instance Matching: An Alternate Approach (2015)

Instance matching concerns identifying pairs of instances that refer to the same underlying entity. Current state-of-the-art instance matchers use machine learning methods. Supervised learning systems achieve good performance by training on significant amounts of manually labeled samples. To alleviate the labeling effort, this poster (The work presented herein is also being published as a full conference paper at ESWC 2015. This poster provides a more high-level overview and discusses supplemental experimental findings beyond the scope of the material in the full paper.) presents a minimally supervised instance matching approach that is able to deliver competitive performance using only 2 % training data. As a first step, a committee of base classifiers is trained in an ensemble setting using boosting. Iterative semi-supervised learning is used to improve the performance of the ensemble classifier even further, by self-training it on the most confident samples labeled in the current iteration. Empirical evaluations on real-world data show that, using a multilayer perceptron as base classifier, the system is able to achieve an average F-Measure that is within 2.5 % of that of state-of-the-art supervised systems.
FPRA: A Fine-grained Parallel RRAM Architecture (2021)

Emerging resistive memory (RRAM) based crossbar array is a promising technology to accelerate neural network applications. RRAM-based CNN accelerators support a high-degree of intra-layer and inter-layer parallelism. The intra-layer parallelism duplicates kernels for each network layer while the inter-layer parallelism allows execution of each layer when a portion of input data is available. However, previously proposed RRAM-based accelerators do not leverage data sharing between duplicate kernels leading to significant idleness of crossbar arrays during inference. This shared data creates data dependencies that stall the processing of the next layer in the pipeline. To address these issues, we propose Fine-grained Parallel RRAM Architecture (FPRA), a novel architectural design, to improve parallelism for pipeline-enabled RRAM-based accelerators. FPRA addresses the data sharing issue with kernel batching and data sharing aware memory. Kernel batching rearranges the layout of the kernels and minimizes the data dependencies created by the input shared data. The data sharing aware memory uniformly buffers the input and output data for each layer, efficiently dispatching data to duplicate kernels while reducing the amount of data transferred between layers. We evaluate FPRA on eight popular image recognition CNN models with various configurations in a cycle-accurate simulator. We find that FPRA manages to achieve 2.0 $\times$ average latency speedup, and 2.1 $\times$ average throughput increase, as compared to the state-of-the-art RRAM-based accelerators.
Preparation of Strontium Titanate-Coated Barium Titanate Accumulation Ceramics by Solvothermal Synthesis and their Dielectric Property (2013)

The strontium titanate (SrTiO 3 , ST) -coated barium titanate (BaTiO 3 , BT) complex nanoparticles was prepared. Using this condition, ST-coated BT (ST/BT) and ST-coated ST (ST/ST) nanocube accumulation ceramics were successfully prepared with epitaxial interface between ST and BT. Dielectric properties were measured for the both accumulation ceramics, but there was no difference of the dielectric properties between both ceramics, and the origin of the result was discussed.
All-wood, low tortuosity, aqueous, biodegradable supercapacitors with ultra-high capacitance (2017)

Natural wood-based materials are directly utilized to construct ultra-thick all-wood-structured supercapacitors with ultra-high capacitance and energy density.
GWAS identifies a wheat orthologue of the rice D11 gene as an important contributor to grain size in an international collection of hexaploid wheat (2021)

Abstract Grain size is a key agronomic trait that contributes to grain yield in hexaploid wheat. Grain length and width were evaluated in an international collection of 159 wheat accessions. These accessions were genetically characterized using a genotyping-by-sequencing (GBS) protocol that produced 73,784 single nucleotide polymorphism (SNP) markers. GBS-derived genotype calls obtained on Chinese Spring proved extremely accurate when compared to the reference (&gt; 99.9%) and showed &gt; 95% agreement with calls made at SNP loci shared with the 90K SNP array on a subset of 71 Canadian wheat accessions for which both types of data were available. This indicates that GBS can yield a large amount of highly accurate SNP data in hexaploid wheat. The genetic diversity analysis performed using this set of SNP markers revealed the presence of six distinct groups within this collection. A GWAS was conducted to uncover genomic regions controlling variation for grain length and width. In total, seven SNPs were found to be associated with one or both traits, identifying three quantitative trait loci (QTLs) located on chromosomes 1D, 2D and 4A. In the vicinity of the peak SNP on chromosome 2D, we found a promising candidate gene (TraesCS2D01G331100), whose rice ortholog (D11) had previously been reported to be involved in the regulation of grain size. These markers will be useful in breeding for enhanced wheat productivity.
Further Enhancement of Rate Capability of Sol-Gel Derived Nanostructured LiFePO4 by Multi-Walled Carbon Nanotubes (2007)

Abstract not Available.
Mild and Selective Oxygenation of Sulfides to Sulfoxides and Sulfones by Perfluoro-cis-2,3-dialkyloxaziridines (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMild and Selective Oxygenation of Sulfides to Sulfoxides and Sulfones by Perfluoro-cis-2,3-dialkyloxaziridinesDarryl D. DesMarteau, Viacheslav A. Petrov, Vittorio Montanari, Massimo Pregnolato, and Giuseppe ResnatiCite this: J. Org. Chem. 1994, 59, 10, 2762–2765Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://doi.org/10.1021/jo00089a020Request reuse permissionsArticle Views458Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (527 KB) Get e-Alertsclose Get e-Alerts
Readout of a quantum processor with high dynamic range Josephson parametric amplifiers (2023)

We demonstrate a high dynamic range Josephson parametric amplifier (JPA) in which the active nonlinear element is implemented using an array of rf-SQUIDs. The device is matched to the 50 Ω environment with a Klopfenstein-taper impedance transformer and achieves a bandwidth of 250–300 MHz with input saturation powers up to −95 dBm at 20 dB gain. A 54-qubit Sycamore processor was used to benchmark these devices, providing a calibration for readout power, an estimation of amplifier added noise, and a platform for comparison against standard impedance matched parametric amplifiers with a single dc-SQUID. We find that the high power rf-SQUID array design has no adverse effect on system noise, readout fidelity, or qubit dephasing, and we estimate an upper bound on amplifier added noise at 1.6 times the quantum limit. Finally, amplifiers with this design show no degradation in readout fidelity due to gain compression, which can occur in multi-tone multiplexed readout with traditional JPAs.
Breastfeeding and infant growth in offspring of mothers with hyperglycaemia in pregnancy: The pregnancy and neonatal diabetes outcomes in remote Australia study (2022)

Predominant breastfeeding was associated with reduced growth among children born to women with and without hyperglycaemia in pregnancy. However, among children exposed to GDM in utero, maternal obesity largely explained this association.
Remeasurement of the CuKα1 Emission X-Ray Wavelength in the Metrical System (Present Stage) (1991)

Using a crystal which lattice parameter is measured firstly with simultaneous X-ray and optical interferometry in the metrical system and secondly with a diffractometric measurement with respect to the X-ray line the wavelength of the characteristic CuKα1 emission line is remeasured with an accuracy, Δλ/λ, of about 3 × 10−7 in the metrical system. Mit einem Kristall, dessen Gitterparameter zuerst mit simultaner Röntgen- und optischer Inter-ferometrie im metrischen System und dann mit einer Beugungsmethode in Bezug auf die Röntgenlinie gemessen wird, wird die Wellenlänge der charakteristischen CuKα1 Emissionslinie mit einer Genauigkeit Δλ/λ, von etwa 3 × 10−7 im metrischen System neu vermessen.