gebhart/patrepeval huggingface dataset:
Structure of Activated Complex of CO2Formation in a CO + O2Reaction on Pd(110) and Pd(111) (2005)

Examinations of CO2 formed during steady-state CO oxidation reactions were performed using infrared (IR) chemiluminescence. The CO2 was formed using a molecular-beam method over Pd(110) and Pd(111). The CO2 formation rate is temperature dependent under various partial pressure conditions. The temperature of the maximum formation rate is denoted as TSmax. Analyses of IR emission spectra at surface temperatures higher than TSmax showed that the average vibrational temperature (TVAV) is higher for Pd(111) than for Pd(110). The antisymmetric vibrational temperature (TVAS) is almost equal on both surfaces. These results suggest that the activated CO2 complex is more bent on Pd(111) and straighter on Pd(110). Furthermore, the difference in the TVAV value was small for surface temperatures less than TSmax. The TVAS value was much higher than TVAV on both surfaces. These phenomena were observed only when the surface temperature was lower than TSmax: they became more pronounced at lower temperatures, suggesting that the activated complex of CO2 formation is much straighter on both Pd surfaces than that observed at higher surface temperatures. Combined with kinetic results, the higher CO coverage at the lower surface temperatures is inferred to be related to the linear activated complex of CO2 formation.
Do Cyborgs dream of Electric Limbs? Experiential Factors in Human-Computer Integration Design and Evaluation (2021)

While many systems have successfully demonstrated functional integration of humans and technology, little attention has been paid to how technologies might experientially integrate to feel as part of humans. Our aim is to shed light on the importance of experiential integration and provide researchers with a scientifically driven foundation for future designs and investigations. The workshop will consist of hands-on experiments with novel body-illusions, discussions on experiential integration, and instructor-guided sessions on psychological concepts related to the design and evaluation of experiential integration.
Bacillus Spore Inactivation Methods Affect Detection Assays (2001)

Detection of biological weapons is a primary concern in force protection, treaty verification, and safeguarding civilian populations against domestic terrorism. One great concern is the detection of Bacillus anthracis, the causative agent of anthrax. Assays for detection in the laboratory often employ inactivated preparations of spores or nonpathogenic simulants. This study uses several common biodetection platforms to detect B. anthracis spores that have been inactivated by two methods and compares those data to detection of spores that have not been inactivated. The data demonstrate that inactivation methods can affect the sensitivity of nucleic acid- and antibody-based assays for the detection of B. anthracis spores. These effects should be taken into consideration when comparing laboratory results to data collected and assayed during field deployment.
The D90A mutation results in a polymorphism of Cu, Zn superoxide dismutase that is prevalent in northern Sweden and Finland (1995)

Journal Article The D90A mutation results in a polymorphism of Cu, Zn superoxide dismutase that is prevalent in northern Sweden and Finland Get access A. Själander, A. Själander 1Department of Medical Genetics, Umeå University, UmeåSweden Search for other works by this author on: Oxford Academic PubMed Google Scholar G. Beckman, G. Beckman 1Department of Medical Genetics, Umeå University, UmeåSweden Search for other works by this author on: Oxford Academic PubMed Google Scholar H.-X. Deng, H.-X. Deng 2Department of Neurology Search for other works by this author on: Oxford Academic PubMed Google Scholar Z. lqbal, Z. lqbal 2Department of Neurology4Northwestern University Institute of Neuroscience, Northwestern University Medical SchoolChicago, IL 60611 Search for other works by this author on: Oxford Academic PubMed Google Scholar J.A. Tainer, J.A. Tainer 5Department of Molecular Biology, The Scripps Research InstituteLa Jolla, CA 92037, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar T. Siddique T. Siddique * 2Department of Neurology4Northwestern University Institute of Neuroscience, Northwestern University Medical SchoolChicago, IL 60611 *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Molecular Genetics, Volume 4, Issue 6, June 1995, Pages 1105–1108, https://doi.org/10.1093/hmg/4.6.1105 Published: 01 June 1995 Article history Received: 20 February 1995 Accepted: 27 March 1995 Published: 01 June 1995
Response to: “Tanezumab: Therapy targeting nerve growth factor in pain pathogenesis” (2018)

Madam, We read with interest the recently published review article by Patel et al. titled “Tanezumab: Therapy targeting nerve growth factor in pain pathogenesis.”[1] Tanezumab is under investigation for the treatment of osteoarthritis pain and chronic low back pain by Pfizer Inc. and Eli Lilly & Company. As Pfizer or Lilly were not involved or consulted regarding the content of this article, we would like to point out that the molecular formula of tanezumab presented in Figure 1 is incorrect. For a more accurate representation of the structure of tanezumab, we refer readers to an article by La Porte et al.[2] —On behalf of the tanezumab development team. Financial support and sponsorship Editorial support was provided by Matt Soulsby, PhD, CMPP, of Engage Scientific Solutions and was funded by Eli Lilly & Co and Pfizer. Conflicts of interest Leslie Tive is a full-time employee of, and own stock and/or stock options in, Pfizer Inc. David Shelton is a consultant for, and owns stock in, Pfizer Inc. Lars Viktrup is a full-time employee of, and owns stock and/or stock options in, Eli Lilly & Company.
On the design of SAR apertures using the Cramer-Rao bound (2007)

The Cramer-Rao inequality is applied to the likelihood function of the synthetic aperture radar (SAR) scatterer parameter vector to relate the choice of flight path to estimation performance. Estimation error bounds for the scatterer parameter vector (including height) are developed for multi-dimensional synthetic apertures, and quantify the performance enhancement over a limited sector of the image plane relative to standard-aperture single-pass SAR missions. An efficient means for the design and analysis of SAR waveforms and flight paths is proposed using simulated scattering models that are limited in size. Comparison of the error bounds to those for standard-aperture SAR show that estimates of scatterer range and cross-range positions are accurate for multi-dimensional aperture SAR, even with the additional estimator for height. Furthermore, multi-dimensional SAR is shown to address the layover problem
High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9 (2021)

Plasma MDMs in combination with CA19-9 detect PDAC with significantly higher accuracy compared with either biomarker individually.
Identification of miR-30b-3p and miR-30d-5p as direct regulators of androgen receptor signaling in prostate cancer by complementary functional microRNA library screening (2016)

The Androgen Receptor (AR) plays a key role in prostate biology and in the progression of prostate cancer (PCa) to castration resistance. The role of microRNAs (miRNAs) in aberrant AR signaling have not been fully characterized. Here we screened a library of 810 miRNA mimics to identify miRNAs that alter AR activity in complementary functional assays including protein lysate microarray (LMA) quantification of AR and PSA protein levels, AR transcriptional reporter activity, and AR-positive PCa cell viability. Candidate AR-regulating miRNAs were verified through AR transcriptional reporter and cell viability assays. MiRNA binding sites were found within the AR 3'-untranslated region (UTR) and within the AR and AR-V7 coding regions. MiRNA activity was characterized by western blotting, 3'-UTR reporter assay, and AR-GFP and AR-V7-GFP reporter assays. Results uncovered miR-30 family members as direct AR inhibitors. Inhibition of endogenous miR-30b-3p and miR-30d-5p enhanced AR expression and androgen-independent cell growth. Droplet digital RT-PCR quantification of miR-30c-5p and miR-30d-5p revealed significantly reduced levels in metastatic castration resistant PCa (CRPC), when compared to healthy prostate tissues. MiR-30d-5p levels were inversely correlated with AR activity, as measured by PSA mRNA, in metastatic CRPC. Collectively, these studies provide a comprehensive evaluation of AR-regulating miRNAs in PCa.
Integrated microsystems for molecular pathology (2011)

We have integrated electronic, optical, magnetic, thermal and fluidic devices into systems to construct useful analysis tools. Over the past several years, we have developed soft lithography approaches to define microfluidic systems in which pico-Liter volumes can be manipulated. These fluidic delivery systems have more recently been integrated with optical and electronic devices. We have also developed thermal control systems with fast (&gt;50oC/s) cooling and heating ramp speeds and excellent accuracy.
Differential Electrode Equilibria, A More Comprehensive Potentiometric Sensor Mechanism (2006)

Abstract not Available.
Comment on ‘‘Direct observation of an organic superlattice structure’’ (1994)

A Comment on the Letter by Y. Imanishi et al., Phys. Rev. Lett. 71, 2098 (1993).Received 2 November 1993DOI:https://doi.org/10.1103/PhysRevLett.72.2308©1994 American Physical Society
Using Models to Provide Predicted Ranges for Building-Human Interfaces: Preprint (2013)

Most building energy consumption dashboards provide only a snapshot of building performance; whereas some provide more detailed historic data with which to compare current usage. This paper will discuss the Building Agent(tm) platform, which has been developed and deployed in a campus setting at the National Renewable Energy Laboratory as part of an effort to maintain the aggressive energyperformance achieved in newly constructed office buildings and laboratories. The Building Agent(tm) provides aggregated and coherent access to building data, including electric energy, thermal energy, temperatures, humidity, and lighting levels, and occupant feedback, which are displayed in various manners for visitors, building occupants, facility managers, and researchers. This paper focuseson the development of visualizations for facility managers, or an energy performance assurance role, where metered data are used to generate models that provide live predicted ranges of building performance by end use. These predicted ranges provide simple, visual context for displayed performance data without requiring users to also assess historical information or trends. Several energymodelling techniques were explored including static lookup-based performance targets, reduced-order models derived from historical data using main effect variables such as solar radiance for lighting performance, and integrated energy models using a whole-building energy simulation program.
Automated optimization of look-up table implementation for function evaluation on FPGAs (2009)

This paper presents a systematic approach for automatic generation of look-up-table (LUT) for function evaluations and minimization in hardware resource on field programmable gate arrays (FPGAs). The class of functions supported by this approach includes sine, cosine, exponentials, Gaussians, the central B-splines, and certain cylinder functions that are frequently used in applications for signal and image processing and data processing. In order to meet customer requirements in accuracy and speed as well as constraints on the use of area and on-chip memory, the function evaluation is based on numerical approximation with Taylor polynomials. Customized data precisions are supported in both fixed point and floating point representations. The optimization procedure involves a search in three-dimensional design space of data precision, sampling density and approximation degree. It utilizes both model-based estimates and gradient-based information gathered during the search. The approach was tested with actual synthesis results on the Xilinx Virtex-2Pro FPGA platform.
On the throughput capacity of random wireless networks (2004)

We consider the problem of how throughput in a wireless network with randomly located nodes scales as the number of users n grows. We show that randomly scattered nodes can achieve the same 1/ √ n per-node transmission rate of arbitrarily located nodes. This contrasts with previous achievable results suggesting that a 1/ √ n log n reduced rate is the price to pay for the additional randomness introduced into the system. Our results rely on percolation theory arguments. When the node density is too high the network is fully connected but generates excessive interference. In the low density regime the network looses connectivity. Percolation theory ensures that a connected backbone forms in the transition region between these two extreme scenarios. This backbone does not include all the nodes, nevertheless it is sufficiently rich in crossing paths so that it can transport the total amount of traffic. By operating the network in this transition region between order and disorder, we are able to prove our tight bound.
3D osteogenic differentiation of human iPSCs reveals the role of TGFβ signal in the transition from progenitors to osteoblasts and osteoblasts to osteocytes (2023)

Although the formation of bone-like nodules is regarded as the differentiation process from stem cells to osteogenic cells, including osteoblasts and osteocytes, the precise biological events during nodule formation are unknown. Here we performed the osteogenic induction of human induced pluripotent stem cells using a three-dimensional (3D) culture system using type I collagen gel and a rapid induction method with retinoic acid. Confocal and time-lapse imaging revealed the osteogenic differentiation was initiated with vigorous focal proliferation followed by aggregation, from which cells invaded the gel. Invading cells changed their morphology and expressed osteocyte marker genes, suggesting the transition from osteoblasts to osteocytes. Single-cell RNA sequencing analysis revealed that 3D culture-induced cells with features of periosteal skeletal stem cells, some of which expressed TGFβ-regulated osteoblast-related molecules. The role of TGFβ signal was further analyzed in the transition from osteoblasts to osteocytes, which revealed that modulation of the TGFβ signal changed the morphology and motility of cells isolated from the 3D culture, suggesting that the TGFβ signal maintains the osteoblastic phenotype and the transition into osteocytes requires down-regulation of the TGFβ signal.
Data from Dual IGF-I/II–Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth (2023)

&lt;div&gt;Abstract&lt;p&gt;Insulin-like growth factors (IGF), IGF-I and IGF-II, are small polypeptides involved in regulating cell proliferation, survival, differentiation, and transformation. IGF activities are mediated through binding and activation of IGF-1R or insulin receptor isoform A (IR-A). The role of the IGF-1R pathway in promoting tumor growth and survival is well documented. Overexpression of IGF-II and IR-A is reported in multiple types of cancer and is proposed as a potential mechanism for cancer cells to develop resistance to IGF-1R–targeting therapy. MEDI-573 is a fully human antibody that neutralizes both IGF-I and IGF-II and inhibits IGF signaling through both the IGF-1R and IR-A pathways. Here, we show that MEDI-573 blocks the binding of IGF-I and IGF-II to IGF-1R or IR-A, leading to the inhibition of IGF-induced signaling pathways and cell proliferation. MEDI-573 significantly inhibited the &lt;i&gt;in vivo&lt;/i&gt; growth of IGF-I– or IGF-II–driven tumors. Pharmacodynamic analysis demonstrated inhibition of IGF-1R phosphorylation in tumors in mice dosed with MEDI-573, indicating that the antitumor activity is mediated via inhibition of IGF-1R signaling pathways. Finally, MEDI-573 significantly decreased &lt;sup&gt;18&lt;/sup&gt;F-fluorodeoxyglucose (&lt;sup&gt;18&lt;/sup&gt;F-FDG) uptake in IGF-driven tumor models, highlighting the potential utility of &lt;sup&gt;18&lt;/sup&gt;F-FDG-PET as a noninvasive pharmacodynamic readout for evaluating the use of MEDI-573 in the clinic. Taken together, these results demonstrate that the inhibition of IGF-I and IGF-II ligands by MEDI-573 results in potent antitumor activity and offers an effective approach to selectively target both the IGF-1R and IR-A signaling pathways. &lt;i&gt;Cancer Res; 71(3); 1029–40. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Clinical assessment of tolerability, immunological and cutaneous reactivity effects of an abbreviated schedule with Olea europaeanative extract of subcutaneous immunotherapy (2019)

Objectives. To evaluate the tolerability and efficacy of Olea europaea subcutaneous immunotherapy (SCIT) on patients with rhinoconjunctivitis. Methods. In this open clinical trial patients were assigned to an abbreviated build-up scheme. The outcomes were: number, percentage, and severity of adverse reactions. Secondary outcomes included: changes in immunoglobulin titers and changes in dose-response skin prick tests. Results. Only 8 systemic reactions were registered, which represented 7/47 (14.9%) of patients and 8/429 (1.9%) of administered doses. Regarding immunological parameters the significant increases of sIgG and sIgG4 evidenced the changes in the patient immune system. Cutaneous reactivity decreased significantly. Conclusions. Olea europaea SCIT (Allergovac® depot ROXALL Medicina España S.A.) showed a good safety and tolerability profile. Immunological changes with induction of blocking IgG and decreases in cutaneous reactivity were detected in the patients.
In situ isobaric lipid mapping by MALDI–ion mobility separation–mass spectrometry imaging (2020)

The highly diverse chemical structures of lipids make their analysis directly from biological tissue sections extremely challenging. Here, we report the in situ mapping and identification of lipids in a freshwater crustacean Gammarus fossarum using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) in combination with an additional separation dimension using ion mobility spectrometry (IMS). The high-resolution trapped ion mobility spectrometry (TIMS) allowed efficient separation of isobaric/isomeric lipids showing distinct spatial distributions. The structures of the lipids were further characterized by MS/MS analysis. It is demonstrated that MALDI MSI with mobility separation is a powerful tool for distinguishing and localizing isobaric/isomeric lipids.
Human cytomegalovirus inhibits IFN-alpha-stimulated antiviral and immunoregulatory responses by blocking multiple levels of IFN-alpha signal transduction. (1999)

The type I IFNs represent a primordial, tightly regulated defense system against acute viral infection. IFN-alpha confers resistance to viral infection by activating a conserved signal transduction pathway that up-regulates direct antiviral effectors and induces immunomodulatory activities. Given the critical role of IFN-alpha in anti-human cytomegalovirus (HCMV) immunity and the profound ability of HCMV to escape the host immune response, we hypothesized that HCMV blocks IFN-alpha-stimulated responses by disrupting multiple levels of the IFN-alpha signal transduction pathway. We demonstrate that HCMV inhibits IFN-alpha-stimulated MHC class I, IFN regulatory factor-1, MxA and 2',5-oligoadenylate synthetase gene expression, transcription factor activation, and signaling in infected fibroblasts and endothelial cells by decreasing the expression of Janus kinase 1 and p48, two essential components of the IFN-alpha signal transduction pathway. This investigation is the first to report inhibition of type I IFN signaling by a herpesvirus. We propose that this novel immune escape mechanism is a major means by which HCMV is capable of escaping host immunity and establishing persistence.
Intra-sentential Zero Anaphora Resolution using Subject Sharing Recognition (2015)

In this work, we improve the performance of intra-sentential zero anaphora resolution in Japanese using a novel method of recognizing subject sharing relations. In Japanese, a large portion of intrasentential zero anaphora can be regarded as subject sharing relations between predicates, that is, the subject of some predicate is also the unrealized subject of other predicates. We develop an accurate recognizer of subject sharing relations for pairs of predicates in a single sentence, and then construct a subject shared predicate network, which is a set of predicates that are linked by the subject sharing relations recognized by our recognizer. We finally combine our zero anaphora resolution method exploiting the subject shared predicate network and a state-ofthe-art ILP-based zero anaphora resolution method. Our combined method achieved a significant improvement over the the ILPbased method alone on intra-sentential zero anaphora resolution in Japanese. To the best of our knowledge, this is the first work to explicitly use an independent subject sharing recognizer in zero anaphora resolution.
In-Situ Force Augmentation Improves Surface Contact and Force Control (2017)

Surgeons routinely perform surgery with noisy, sub-threshold, or obscured visual and haptic feedback, either due to the necessary surgical approach, or because the systems on which they are operating are exceedingly delicate. Technological solutions incorporating haptic feedback augmentation have been proposed to address these difficulties, but the consequences for motor control have not been directly investigated and quantified. In this paper, we present two isometric force generation tasks performed with a hand-held robotic tool that provides in-situ augmentation of force sensation. An initial study indicated that magnification helps the operator maintain a desired supra-threshold target force in the absence of visual feedback. We further found that such force magnification reduces the mean and standard deviation of applied forces, and reduces the magnitude of power in the 4 to 7 Hz band corresponding to tremor. Specific benefits to stability, voluntary control, and tremor were observed in the pull direction, which has been previously identified as more dexterous compared to push.