gebhart/patrepeval huggingface dataset:
Complement activation patterns in atypical haemolytic uraemic syndrome during acute phase and in remission (2014)

Atypical haemolytic uraemic syndrome (aHUS) is associated with (genetic) alterations in alternative complement pathway. Nevertheless, comprehensive evidence that the complement system in aHUS patients is more prone to activation is still lacking. Therefore, we performed a thorough analysis of complement activation in acute phase and in remission of this disease. Complement activation patterns of the aHUS patients in acute phase and in remission were compared to those of healthy controls. Background levels of complement activation products C3b/c, C3bBbP and terminal complement complex (TCC) were measured using enzyme-linked immunosorbent assay (ELISA) in ethylenediamine tetraacetic acid (EDTA) plasma. In vitro-triggered complement activation in serum samples was studied using zymosan-coating and pathway-specific assay. Furthermore, efficiencies of the C3b/c, C3bBbP and TCC generation in fluid phase during spontaneous activation were analysed. Patients with acute aHUS showed elevated levels of C3b/c (P < 0·01), C3bBbP (P < 0·0001) and TCC (P < 0·0001) in EDTA plasma, while values of patients in remission were normal, compared to those of healthy controls. Using data from a single aHUS patient with complement factor B mutation we illustrated normalization of complement activation during aHUS recovery. Serum samples from patients in remission showed normal in vitro patterns of complement activation and demonstrated normal kinetics of complement activation in the fluid phase. Our data indicate that while aHUS patients have clearly activated complement in acute phase of the disease, this is not the case in remission of aHUS. This knowledge provides important insight into complement regulation in aHUS and may have an impact on monitoring of these patients, particularly when using complement inhibition therapy.
Intensive consolidation with G‐CSF support: Tolerability, safety, reduced hospitalization, and efficacy in acute myeloid leukemia patients ≥60 years (2017)

The aim of this study was to evaluate the efficacy and feasibility of intensified consolidation therapy employing fludarabine and ARA-C in cycle 1 and intermediate-dose ARA-C (IDAC) in cycles 2 through 4, in elderly acute myeloid leukemia (AML) patients and to analyze the effects of pegfilgrastim on the duration of neutropenia, overall toxicity, and hospitalization-time during consolidation in these patients. Thirty nine elderly patients with de novo AML (median age 69.9 years) who achieved complete remission (CR) after induction-chemotherapy were analyzed. To examine the effect of pegfilgrastim on neutropenia and hospitalization, we compared cycles 2 and 4 where pegfilgrastim was given routinely from day 6 (IDAC-P) with cycle 3 where pegfilgrastim was only administered in case of severe infections and/or prolonged neutropenia. All four planned cycles were administered in 23/39 patients (59.0%); 5/39 patients (12.8%) received 3 cycles, 3/39 (7.7%) 2 cycles, and 8/39 (20.5%) one consolidation-cycle. The median duration of severe neutropenia was 7 days in cycle 2 (IDAC-P), 11.5 days in cycle 3 (IDAC), and 7.5 days in cycle 4 (IDAC-P) (P < .05). Median overall survival was 1.1 years and differed significantly between patients aged <75 and ≥75 years (P < .05). The probability to be alive after 5 years was 32%. Together, intensified consolidation can be administered in AML patients ≥60, and those who are <75 may benefit from this therapy. Routine administration of pegfilgrastim during consolidation shortens the time of neutropenia and hospitalization in these patients.
Precise pitch-scaling of carbon nanotube arrays within three-dimensional DNA nanotrenches (2020)

Precise fabrication of semiconducting carbon nanotubes (CNTs) into densely aligned evenly spaced arrays is required for ultrascaled technology nodes. We report the precise scaling of inter-CNT pitch using a supramolecular assembly method called spatially hindered integration of nanotube electronics. Specifically, by using DNA brick crystal-based nanotrenches to align DNA-wrapped CNTs through DNA hybridization, we constructed parallel CNT arrays with a uniform pitch as small as 10.4 nanometers, at an angular deviation <2° and an assembly yield >95%.
AppMine: Behavioral Analytics for Web Application Vulnerability Detection (2019)

Web applications in widespread use have always been the target of large-scale attacks, leading to massive disruption of services and financial loss, as in the Equifax data breach. It has become common practice to deploy web application in containers like Docker for better portability and ease of deployment. We design a system called AppMine for lightweight monitoring of web applications running in Docker containers and detection of unknown web vulnerabilities. AppMine is an unsupervised learning system, trained only on legitimate workloads of web application, to detect anomalies based on either traditional models (PCA and one-class SVM), or more advanced neural-network architectures (LSTM). In our evaluation, we demonstrate that the neural network model outperforms more traditional methods on a range of web applications and recreated exploits. For instance, AppMine achieves average AUC scores as high as 0.97 for the Apache Struts application (with the CVE-2017-5638 exploit used in the Equifax breach), while the AUC scores for PCA and one-class SVM are 0.81 and 0.83, respectively.
Drag force measurement: A means for determining hysteresis loss (2006)

A method for determining hysteresis losses in thin strips of soft magnetic materials is described. It is based on the measurement of a drag force which arises with the movement of the sample through the strong field existing in the space near a permanent magnet. Not associated with macro eddy currents, the force is shown to originate from the magnetic hysteresis of the material, having, in fact, an amplitude equal to the product of hysteresis loss and the area of the sample cross section. Correlation within 18% with the measurements made by conventional methods is shown for a wide range of experimental materials.
Electrical Interrogation of Thickness‐Dependent Multiferroic Phase Transitions in the 2D Antiferromagnetic Semiconductor NiI2 (2023)

Abstract 2D magnetic materials hold promise for quantum and spintronic applications. 2D antiferromagnetic materials are of particular interest due to their relative insensitivity to external magnetic fields and higher switching speeds compared to 2D ferromagnets. However, their lack of macroscopic magnetization impedes detection and control of antiferromagnetic order, thus motivating magneto‐electrical measurements for these purposes. Additionally, many 2D magnetic materials are ambient‐reactive and electrically insulating or highly resistive below their magnetic ordering temperatures, which imposes severe constraints on electronic device fabrication and characterization. Herein, these issues are overcome via a fabrication protocol that achieves electrically conductive devices from the ambient‐reactive 2D antiferromagnetic semiconductor NiI 2 . The resulting gate‐tunable transistors show band‐like electronic transport below the antiferromagnetic and multiferroic transition temperatures of NiI 2 , revealing a Hall mobility of 15 cm 2 V −1 s −1 at 1.7 K. These devices also allow direct electrical probing of the thickness‐dependent multiferroic phase transition temperature of NiI 2 from 59 K (bulk) to 28 K (monolayer).
Rapid Magnetic Catch-and-Release Purification by Hydrophobic Interactions (2009)

A reversible, conventional, and rapid purification method of hydrophobically tagged products using hydrophobic magnetic nanoparticles was developed. The reversible purification system entails simply controlling the polarity of solvents. First, for the catching procedure, poor solvents were added into a well-dispersed system of magnetic nanoparticles and tagged products. Once the poor solvents were added to the system, the products were recrystallized among the nanoparticles and the aggregation of magnetic nanoparticles occurred due to hydrophobic interactions. These aggregates with the products contained within them were able to be collected rapidly by magnets. Then, the releasing procedure can be easily performed by redispersing the collected aggregates into good solvents. The availability of this purification protocol was confirmed by using a hydrophobically tagged fluorescent model product. Furthermore, this rapid purification method was successfully applied to a peptide elongation reaction system which enabled the synthesis of peptides such as Leu-Enkephalin in high purity, in high yield, and in a short time.
ChemInform Abstract: Synthesis of Tri‐ and Tetrasubstituted Imidazoles. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Transgenic tobacco transformed with theTrichopusia niGranulovirusEnhancingene affects insect development (2004)

Transgenic tobacco transformed with the Trichoplusia ni granulovirus enhancin gene has been demonstrated to enhance baculovirus infection in larvae. In this paper we describe the effect of the long-term feeding of lyophilized transgenic tobacco material to Pseudaletia separata and Spodoptera exigua larvae. Our results demonstrated that the baculovirus enhancin gene products have potential for use in insect pest management.
NASA-NIAC 2001 Phase I Research Grant on Aneutronic Fusion Spacecraft Architecture (2012)

This study was developed because the recognized need of defining of a new spacecraft architecture suitable for aneutronic fusion and featuring game-changing space travel capabilities. The core of this architecture is the definition of a new kind of fusion-based space propulsion system. This research is not about exploring a new fusion energy concept, it actually assumes the availability of an aneutronic fusion energy reactor. The focus is on providing the best (most efficient) utilization of fusion energy for propulsion purposes. The rationale is that without a proper architecture design even the utilization of a fusion reactor as a prime energy source for spacecraft propulsion is not going to provide the required performances for achieving a substantial change of current space travel capabilities.
Multimedia information retrieval (2007)

With the rising popularity of rich media services such as Flickr, YouTube, and Jumpcut, new challenges in large scale multimedia information retrieval have emerged that not only rely on meta-data but on content-based information retrieval combined with the collective knowledge of users and geo-referenced meta-data that is captured during the creation process. For the future, it is envisioned that multimedia search in mobile environments or on P2P networks will take off on a large scale.
Faculty Opinions recommendation of Aerobic fitness is associated with gray matter volume and white matter integrity in multiple sclerosis. (2009)

Alterations in gray and white matter have been well documented in individuals with multiple sclerosis. Severity and extent of such brain tissue damage have been associated with cognitive impairment, disease duration and neurological disability, making quantitative indices of tissue damage important markers of disease progression. In this study, we investigated the association between cardiorespiratory fitness and measures of gray matter atrophy and white matter integrity. Employing voxel-based approaches to analysis of gray matter and white matter, we specifically examined whether higher levels of fitness in multiple sclerosis participants were associated with preserved gray matter volume and integrity of white matter. We found a positive association between cardiorespiratory fitness and regional gray matter volumes and higher focal fractional anisotropy values. Statistical mapping revealed that higher levels of fitness were associated with greater gray matter volume in the midline cortical structures including the medial frontal gyrus, anterior cingulate cortex and the precuneus. Further, we also found that increasing levels of fitness were associated with higher fractional anisotropy in the left thalamic radiation and right anterior corona radiata. Both preserved gray matter volume and white matter tract integrity were associated with better performance on measures of processing speed. Taken together, these results suggest that fitness exerts a prophylactic influence on the structural decline observed early on, preserving neuronal integrity in multiple sclerosis, thereby reducing long-term disability.Copyright 2009 Elsevier B.V. All rights reserved. PMID: 19560443 Funding information This work was supported by: NIA NIH HHS, United States Grant ID: R01 AG025667 NIA NIH HHS, United States Grant ID: R37 AG025667-04S1 NCRR NIH HHS, United States Grant ID: UL1 RR025755 NIA NIH HHS, United States Grant ID: R01 AG25032 NIA NIH HHS, United States Grant ID: R01 AG025032 NIA NIH HHS, United States Grant ID: R37 AG025667 NIA NIH HHS, United States Grant ID: R01AG25667 More Less keyboard_arrow_down
Proteogénomique pour le developpement des biomarqueurs pour la surveillance ecotoxicologique des environnements aquatiques (2018)

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67Ga citrate versus 99mTc-labeled LL2-Fab' (anti-CD22) fragments in the staging of B-cell non-Hodgkin's lymphoma. (1995)

The value of 67Ga citrate scanning as a transferrin receptor agent was compared in this study with a 99mTc-labeled anti-CD22 (B-cell) Fab' fragment (LL2) in patients with low- and high-grade B-cell non-Hodgkin's lymphoma (NHL). Thirteen patients with histologically confirmed NHL were examined prospectively with both radiopharmaceuticals within 8 days. The results of immunoscintigraphy were compared with those of 67Ga scanning and the clinical and radiological workup (computed tomography, ultrasound, and magnetic resonance imaging) of the patients. The overall sensitivity of 67Ga citrate and 99mTc-labeled LL2 fragment was each 80% in a total of 43 lesions. Low-grade lymphoma patients had a higher sensitivity in LL2 imaging (82% versus 71%), and high-grade lymphoma patients in 67Ga citrate scanning (100% versus 75%). The target:background ratio in low-grade NHL for LL2 was 1.43 +/- 0.3:1 versus 1.8 +/- 0.5:1 in 67Ga scans; in high-grade NHL, 1.49 +/- 0.35:1 versus 2.2 +/- 0.8:1, respectively. Single-photon emission computed tomography imaging was necessary in 21.7% of the patients 4 h after injection to localize the lesions. In conclusion, the overall sensitivity of 99mTc-labeled LL2 is comparable to 67Ga citrate scanning in patients with B-cell NHL. 99mTc-labeled LL2 antibodies are rapid to use, are safe, and need a shorter imaging time (24 h versus 72 h). Because of these advantages, 99mTc-labeled LL2 may be superior to 67Ga scanning for the staging of lymphoma patients.
USING SIMULATORS AND PROGRAMMING SOFTWARE TO EASE STUDENTS THE UNDERSTANDING OF POWER SYSTEM ANALYSIS (2017)

USING SIMULATORS AND PROGRAMMING SOFTWARE TO EASE STUDENTS THE UNDERSTANDING OF POWER SYSTEM ANALYSIS
Impact of composition and structural parameters on the catalytic activity of MFI type titanosilicalites (2022)

Titanosilicalite of the MFI type was obtained <i>via</i> a hydrothermal method. Its initial and annealed at 75 °C (TS-1P(75)) and 500 °C (TS-1P(500)) forms were studied by X-ray powder diffraction (PXRD), X-ray absorption spectroscopy (XAS-method), Fourier-transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), temperature-programmed ammonia desorption (TPD NH<sub>3</sub>), and pyridine adsorption (Py). The full-profile Rietveld method allowed us to observe the presence of the organic template tetrapropylammonium hydroxide (TPAOH) in the framework voids, as well as to determine the silicate module (Si/Ti = 73.5) and the distribution of Ti<sup>4+</sup> ions over the MFI-type structure sites (Ti atoms replace Si ones in two positions: T1 and T6). The coordination numbers of titanium (CNTi = 4.6 for TS-1P and TS-1P(75), CNTi = 3.8 for TS-1P(500)) were established by the XAS-method. The catalytic activity of titanosilicalites was found in the reactions of nitrous oxide decomposition (the maximal decomposition rate is demonstrated for the TS-1P(75) sample), allyl chloride epoxidation to epichlorohydrin (the best combination of all indicators was exhibited for the TS-1P sample) and propane conversion (maximum propane conversion, and butadiene and propylene selectivity were observed in both TS-1P(75) and TS-1P(500) samples). Mechanisms for the catalytic processes are proposed. The relationship between the catalytic properties and the composition (Si/Ti), Ti<sup>4+</sup> ion distribution over the MFI-type structure sites, the local environment of titanium ions, and the number of acid sites in the titanosilicalites are discussed.
Blockchain based Resource Tokenization for Crowdfunding of Wireless Network Investment (2021)

This paper presents novel blockchain based resource tokenization method to crowdfund wireless network deployment. Crowdfunding is a method of financing certain projects with the funds collected from individuals. The method presented in this paper finances the wireless network deployment projects by tokenizing proposed novel wireless resource units, and selling these units to investors. A new Data Tonnage Unit Per User (DTUPU) resource unit is introduced with a new pricing scheme depending on a load of a base station. A novel Proof of Load (PoLO) consensus algorithm is proposed which is used to verify load of a base station. Traffic Diversity Factor (TDF) and User Difference Factor (UDF) are proposed to determine the value of a base station and a cluster of base stations.
Composite Keys and Signatures For Use In Internet PKI (2020)

With the widespread adoption of post-quantum cryptography will come
the need for an entity to possess multiple public keys on different
cryptographic algorithms. Since the trustworthiness of individual
post-quantum algorithms is at question, a multi-key cryptographic
operation will need to be performed in such a way that breaking it
requires breaking each of the component algorithms individually. This
requires defining new structures for holding composite public keys and
composite signature data. This document defines the structures
CompositePublicKey, CompositeSignatureValue, and CompositeParams,
which are sequences of the respective structure for each component
algorithm. This document also defines algorithms for generating and
verifying composite signatures. This document makes no assumptions
about what the component algorithms are, provided that their algorithm
identifiers and signature generation and verification algorithms are
defined.
A miR-1207-5p Binding Site Polymorphism Abolishes Regulation of HBEGF and Is Associated with Disease Severity in CFHR5 Nephropathy (2012)

Heparin binding epidermal growth factor (HBEGF) is expressed in podocytes and was shown to play a role in glomerular physiology. MicroRNA binding sites on the 3'UTR of HBEGF were predicted using miRWalk algorithm and followed by DNA sequencing in 103 patients diagnosed with mild or severe glomerulopathy. A single nucleotide polymorphism, miRSNP C1936T (rs13385), was identified at the 3'UTR of HBEGF that corresponds to the second base of the hsa-miR-1207-5p seed region. When AB8/13 undifferentiated podocytes were transfected with miRNA mimics of hsa-miR-1207-5p, the HBEGF protein levels were reduced by about 50%. A DNA fragment containing the miRSNP allele-1936C was cloned into the pMIR-Report Luciferase vector and co-transfected with miRNA mimics of hsa-miR-1207-5p into AB8/13 podocytes. In agreement with western blot data, this resulted in reduced luciferase expression demonstrating the ability of hsa-miR-1207-5p to directly regulate HBEGF expression. On the contrary, in the presence of the miRSNP 1936T allele, this regulation was abolished. Collectively, these results demonstrate that variant 1936T of this miRSNP prevents hsa-miR-1207-5p from down-regulating HBEGF in podocytes. We hypothesized that this variant has a functional role as a genetic modifier. To this end, we showed that in a cohort of 78 patients diagnosed with CFHR5 nephropathy (also known as C3-glomerulopathy), inheritance of miRSNP 1936T allele was significantly increased in the group demonstrating progression to chronic renal failure on long follow-up. No similar association was detected in a cohort of patients with thin basement membrane nephropathy. This is the first report associating a miRSNP as genetic modifier to a monogenic renal disorder.
High‐Optical‐Quality Ferroelectric Film Wet‐Processed from a Ferroelectric Columnar Liquid Crystal as Observed by Non‐linear‐Optical Microscopy (2013)

The self-organization of ferroelectric columnar liquid crystals (FCLCs) is demonstrated. Columnar order is spontaneously formed in thin films made by the wet-process due to its liquid crystallinity. Electric-field application results in high optical quality and uniform spontaneous polarization. Such good processability and controllability of the wet-processed FCLC films provide us with potential organic ferroelectric materials for device applications.
Sensor based Image Reconstruction in Electrical Impedance Tomography using Open-Source Technology (2023)

Electrical Impedance Tomography (EIT) is noninvasive imaging methodology with very small current injected in body through electrodes. With current injection, differential voltage is acquired, and these voltages are used for image reconstruction. The accuracy of image reconstruction depends predominantly on dimensions of electrodes and material used. Stainless steel electrode sensor is designed and developed. An open-source reconstruction software EIDORS is used in this work. Circular phantom with conducting and non-conducting impurities are used for experimentation. The phantom is resembling the human body shape and impurities are depicting types of cancerous body tissues. EIT system is thus developed, and the voltage dataset obtained from the system is used further for image reconstruction to analyze the type, position as well as shape of the impurity. Small error between original and reconstructed image of around 6 to 8% is achieved with improved blur radius of 1.06. Also, the percentage of location error is also reduced to 9 to 12%. Development of sensor based EIT system and the experimental results along with open-source image reconstruction approach is the important contribution discussed in this paper which can be used for several biomedical applications.
Novel cytokine–antibody fusion protein, N-820, to enhance the functions of ex vivo expanded natural killer cells against Burkitt lymphoma (2020)

Our results provide the rationale for the development of a clinical trial of N-820 alone or in combination with endogenous or ex vivo expanded NK cells in patients with CD20<sup>+</sup> B-NHL failing prior rituximab containing chemoimmunotherapy regimens.
Adsorbate binding energy and adsorption capacity of xenon on carbon nanohorns (2002)

Xenon adsorption studies were performed on aggregates of single-walled carbon nanohorns (SWNHs). The SWNHs were prepared in two different batches; the adsorption results from the two batches were essentially identical. Isotherms were performed in two groups of experiments: low-coverage data were used to measure the binding energy of Xe on the SWNHs; and full isotherms were measured to determine specific surface areas. The binding energy value for Xe on the SWNHs was intermediate between those for Xe on single-walled carbon nanotubes, and that for Xe on graphite. The specific surface area of the SWNHs was of the order of 250 m2 g-1.