gebhart/patrepeval huggingface dataset:
Piwi-Interacting RNAs (piRNAs) Are Dysregulated in Renal Cell Carcinoma and Associated with Tumor Metastasis and Cancer-Specific Survival (2015)

Piwi-interacting RNAs (piRNAs) are a distinct group of small noncoding RNAs (sncRNAs) that silence transposable genetic elements to protect genome integrity. Because of their limited expression in gonads and sequence diversity, piRNAs remain the most mysterious class of small RNAs. Studies have shown piRNAs are present in somatic cells and dysregulated in gastric, breast and liver cancers. By deep sequencing 24 frozen benign kidney and clear cell renal cell carcinoma (ccRCC) specimens and using the publically available piRNA database, we found 26,991 piRNAs present in human kidney tissue. Among 920 piRNAs that had at least two copies in one specimen, 19 were differentially expressed in benign kidney and ccRCC tissues, and 46 were associated with metastasis. Among the metastasis-related piRNAs, we found three piRNAs (piR-32051, piR-39894 and piR-43607) to be derived from the same piRNA cluster at chromosome 17. We confirmed the three selected piRNAs not to be miRNAs or miRNA-like sncRNAs. We further validated the aberrant expression of the three piRNAs in a 68-case formalin-fixed and paraffin-embedded (FFPE) ccRCC tissue cohort and showed the up-regulation of the three piRNAs to be highly associated with ccRCC metastasis, late clinical stage and poor cancer-specific survival.
FHIT expression in non-small cell lung cancer: Correlation with LOH at 3p14, other genetic abnormalities and clinico-pathologic features (1999)

For a certain kind of decision event, the decision maker does not know the internal mechanism and knowledge information of the decision events.When this kind of decision events gives multiple selection branches, it is found that there is a decision psychological tendency to find the most common features by comparing the selection branches. Based on this, a zero-knowledge decision making (ZKDM) method is proposed. By defining the feature points and feature sets of the selection branches of the decision events, the characteristic moments of the system are constructed and the branch with the most common characteristics is obtained. It is observed that through the findings of investigation the probability of arriving at the correct choice based on the ZKDM method is high. The effectiveness of the ZKDM method may be related to the fact that the designers of decision events usually determine the correct selection branch first, before changing it to design other branches. A questionnaire survey of 279 respondents reveals that more than half of them actually adopt such a design idea. Furthermore, a separate questionnaire survey of 465 decision-makers reveal that 19.14% of the respondents clearly adopt ZKDM.
Direct Wafer Bonding for Nanostructure Preparations (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Tracking Gene-Modified T Cells In Vivo (2009)

Identification, monitoring, and analysis of genetically modified cells in the peripheral blood are an important component of the clinical follow-up of patients treated by hematopoietic cell gene therapy. Analysis of gene-marked peripheral blood cells provides crucial information on gene transfer efficiency as well as on the nature and characteristics of the genetically modified cells, and may provide early evidence of the occurrence of potentially detrimental side effects. T lymphocytes are a convenient target for this type of analysis, due to their abundance and their relatively long life span in vivo. Tracking of gene-marked T cells is based on relatively simple, FACS- and PCR-based techniques, which may be applied to monitoring genetically modified T cells as well as T cells derived from transplanted, genetically modified hematopoietic stem cells. This chapter provides a description of these techniques and clues to their rational use in a clinical setting.
Immunologic and Virologic Events in Early HIV Infection Predict Subsequent Rate of Progression (2009)

Our results demonstrate that the extent of the immunopathogenesis established early in HIV infection predicts the course of future disease. Because antiretroviral drug treatment reverses such defects in part, our study provides mechanistic clues to why early use of antiretrovirals may prove beneficial.
Immune System Modulation with LOFU And HIFU Treatment of Prostate Cancer (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation C. Guha, Z. Huagang, W. Chen, R. Carlosn, N. T. Sanghvi; Immune System Modulation with LOFU And HIFU Treatment of Prostate Cancer. AIP Conference Proceedings 12 September 2011; 1359 (1): 277–282. https://doi.org/10.1063/1.3607918 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity (2022)

DuoBody-CD40×4-1BB is capable of enhancing antitumor immunity by modulating DC and T-cell functions and shows biological activity in patients with advanced solid tumors. These findings demonstrate that targeting of these two pathways with an Fc-inert bispecific antibody may be an efficacious approach to (re)activate tumor-specific immunity and support the clinical investigation of DuoBody-CD40×4-1BB for the treatment of cancer.
ChemInform Abstract: Comparison of Metal‐Hydrogen, ‐Oxygen, ‐Nitrogen and ‐Carbon Bond Strengths and Evaluation of Functional Group Additivity Principles for Organoruthenium and Organoplatinum Compounds. (1989)

Abstract The relative bond strengths for the complexes (I) and (II) are determined from equilibrium measurements.
The Solving Methods of Dwell Time or Pressure in CCOS for Optical Complex Surfaces (2006)

Error correction of optical complex surfaces in computer-controlled optical surfacing (CCOS) is primary important. This paper discusses some methods, i.e. Fourier transform method, Wiener filtering method, directive method and iterative method, for calculating dwell time or relative pressure in the CCOS for error-correcting, which are enlightened from the digital image processing techniques. However, these error correction methods are different from the image processing because they are not a subject of solving the causal signal but a problem of an iterative process. The simulation results show that the Wiener filtering method is good and reliable when the correlative parameters in the fabrication are kept consistent.
Impact of High-Dose Methotrexate on the Outcome of Patients with Diffuse Large B-Cell Lymphoma and Skeletal Involvement (2021)

Diffuse large B-cell lymphoma (DLBCL) with extra nodal skeletal involvement is rare. It is currently unclear whether these lymphomas should be treated in the same manner as those without skeletal involvement. We retrospectively analyzed the impact of combining high-dose methotrexate (HD-MTX) with an anthracycline-based regimen and rituximab as first-line treatment in a cohort of 93 patients with DLBCL and skeletal involvement with long follow-up. Fifty patients (54%) received upfront HD-MTX for prophylaxis of CNS recurrence (high IPI score and/or epidural involvement) or because of skeletal involvement. After adjusting for age, ECOG, high LDH levels, and type of skeletal involvement, HD-MTX was associated with an improved PFS and OS (HR: 0.2, 95% CI: 0.1-0.3, <i>p</i> < 0.001 and HR: 0.1, 95% CI: 0.04-0.3, <i>p</i> < 0.001, respectively). Patients who received HD-MTX had significantly better 5-year PFS and OS (77% vs. 39%, <i>p</i> <0.001 and 83 vs. 58%, <i>p</i> < 0.001). Radiotherapy was associated with an improved 5-year PFS (74 vs. 48%, <i>p</i> = 0.02), whereas 5-year OS was not significantly different (79% vs. 66%, <i>p</i> = 0.09). A landmark analysis showed that autologous stem cell transplantation was not associated with improved PFS or OS. The combination of high-dose methotrexate and an anthracycline-based immunochemotherapy is associated with an improved outcome in patients with DLBCL and skeletal involvement and should be confirmed in prospective trials.
Mild and Efficient Chemoselective Protection of Aldehydes as Dithioacetals Employing N-Bromosuccinimide (2002)

A mild and chemoselective dithioacetalization procedure for the protection of aromatic, aliphatic, and alkenyl aldehydes in presence of catalytic amount of N-bromosuccinimide under neutral conditions is described.
Higher-momentum components of thee+ande−wave functions in Li and K (1985)

Two-dimensional angular correlations of positron-annihilation radiation in Li and K have been measured with high angular resolution. The results are compared with two-photon momentum densities calculated by the Korringa-Kohn-Rostoker method. The comparison shows good agreement for the (110) and (200) higher-momentum components and thus implies that many-body enhancement effects are comparable with those in the (000) zone.
Fc receptors on cultured myeloma and hybridoma cells. (1985)

The specificity of the Fc gamma receptors on the X63.Ag8.653 nonproducing myeloma cell line has been examined for binding to IgG1-, IgG2a-, and IgG2b-containing antigen-antibody complexes. Complexes containing each of these subclasses bind, and the binding of each is inhibited by the others. Trypsin treatment did not inhibit the binding of any of these subclasses. Furthermore, the monoclonal anti-Fc receptor antibody 2.4G2 inhibits the binding of all three subclasses. These results, together with those of other investigators, suggest that there is a single FcR for IgG1, IgG2a, and IgG2b on mouse B cells which differs in its specificity from the macrophage Fc gamma R. This is confirmed by the fact that a mutant IgG2b myeloma protein which binds to the macrophage Fc gamma 1/gamma 2b receptor does not bind to the Fc gamma R on X63.Ag8.653.
Introducing robotic origami folding (2004)

Origami, the human art of paper sculpture, is a fresh challenge for the field of robotic manipulation, and provides a concrete example for many difficult and general manipulation problems. This paper presents some initial results, including the world's first origami-folding robot, definition of a simple class of origami for which we have designed a complete automatic planner, an analysis of the kinematics of more complicated folds, and some new theorems about foldability.
Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease (2018)

3D printing is a rapidly evolving technology at the forefront of biomedical innovation and cardiovascular 3D printing is one of the most common medical applications (1). Technical advances in biomedical 3D printing have been driven by improved printer technology and image segmentation tools, however, clinical and research applications of cardiovascular are still catching up to such rapid technical advances.
Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini (1994)

The polymerase chain reaction (PCR) was used in combination with plaque hybridization analysis to clone four variants of the EP 3 prostaglandin receptor from a human small intestine cDNA library. Three of these variants, i.e. the EP 3A , EP 3E and EP 3D , share the same primary amino acid sequence except for their carboxyl termini, which diverge from one another at the same point, approximately 10 amino acids away from the end of the seventh membrane spanning domain of the receptor. The fourth variant (EP 3A1 ) has a nucleotide coding sequence identical to EP 3A but has a completely different 3′;untranslated sequence. The carboxyl termini of the three isoforms differ most obviously in length with the EP 3A being the longest (41 amino acids) and the EP 3E being the shortest (16 amino acids). They also differ in content with the EP 3A containing 9 serine and threonines in its carboxyl terminus and the EP 3E none. Transient expression in eukaryotic cells showed that the human EP 3 receptor variants had similar but not identical radioligand binding properties and differed in their functional coupling to second messenger pathways. Up to 3 pmol mg −1 protein of [ 3 H]‐prostaglandin E 2 binding could be obtained with more than 95% specific binding. Using a reporter gene assay, as a measure of intracellular cyclic AMP levels, the EP 3A coupled more efficiently to the inhibition of adenylyl cyclase than did the EP 3E . PCR was used to confirm the presence of mRNAs encoding the four human EP 3 receptor variants in tissues of the human small intestine, heart and pancreas. These findings indicate that the EP 3 receptor variants identified here are likely to be expressed in tissues. The differences in the carboxyl termini at the protein level, and in the 3′ untranslated regions at the mRNA level, could be profound in terms of the regulation and functional coupling of these receptor isoforms.
2-Octyl Cyanoacrylate (Dermabond®) Inhibits Bridging Bone Formation of Articular Fractures in a Rat Model (2021)

One technique often used for small intraarticular fracture fixation involves the use of 2-octyl-cyanoacrylate (2-OCTA) (Dermabond®, Ethicon, Inc., Raritan, USA). The purpose of this study was to determine if 2-OCTA impedes bony healing. Osteochondral plugs in 38 retired Sprague-Dawley rats were created in both hind legs. Each rat had one plug dipped in 2-OCTA before fixation and one control plug. H&E staining was used to quantify bone bridging. The 2-OCTA group had a mean bridging bone circumference of 22.80%, significantly less than 67.75% in the control group (p<0.05). Our data suggests that 2-OCTA blocks bridging bone formation, making it a poor choice for fracture fixation.
Spark-Ignition-Engine Idle Speed Control: An Adaptive Control Approach (2010)

The paper presents an application of a recently developed adaptive posicast controller (APC) for time-delay systems to the idle speed control (ISC) problem in spark ignition (SI) internal combustion (IC) engines. The objective is to regulate the engine speed to a prescribed set-point in the presence of accessory load torque disturbances such as those due to air conditioning and power steering. The adaptive controller, integrated with the existing proportional spark controller, is used to drive the electronic throttle actuator. We present both simulation and experimental results demonstrating the performance improvement by employing the adaptive controller. We also present the modifications and improvements to the controller structure which were developed during the course of experimentation to solve specific problems. In addition, the potential for the reduction in calibration time and effort which can be achieved with our approach is discussed.
A validated lineage-derived somatic truth data set enables benchmarking in cancer genome analysis (2020)

Existing cancer benchmark data sets for human sequencing data use germline variants, synthetic methods, or expensive validations, none of which are satisfactory for providing a large collection of true somatic variation across a whole genome. Here we propose a data set, Lineage derived Somatic Truth (LinST), of short somatic mutations in the HT115 colon cancer cell-line, that are validated using a known cell lineage that includes thousands of mutations and a high confidence region covering 2.7 gigabases per sample.
Sonoluminescence from single bubbles (1990)

Sonoluminescence (SL) is generally attributed to the radiative recombination of hydroxyl radicals produced by the high temperatures and pressures associated with cavitation bubble collapse. SL from a single bubble has been observed in a levitation cell at 20 kHz, which supports this assumption. The pressure amplitudes ranged from 110 kPa for water to 170 kPa for 60% glycerin in water. Pulsation amplitudes were measured to be between five and ten times the equilibium radius. Such large amplitude steady-state pulsations have never been observed before. The possible mechanisms by which stability is maintained will be discussed and theoretical calculations of temperatures and pressures inside the bubble will be presented. [Work supported by ONR.]
Anomalous wide-angle x-ray scattering and x-ray absorption spectroscopy of supported platinum-molybdenum bimetallic clusters. 1. Experimental technique (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnomalous wide-angle x-ray scattering and x-ray absorption spectroscopy of supported platinum-molybdenum bimetallic clusters. 1. Experimental techniqueMahesh G. Samant, Gerard Bergeret, George Meitzner, and Michel BoudartCite this: J. Phys. Chem. 1988, 92, 12, 3542–3546Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/j100323a044https://doi.org/10.1021/j100323a044research-articleACS PublicationsRequest reuse permissionsArticle Views95Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Biodegradable Block Copolyelectrolyte Hydrogels for Tunable Release of Therapeutics and Topical Antimicrobial Skin Treatment (2015)

Biodegradable polycarbonate-based ABA triblock copolyelectrolytes were synthesized and formulated into physically cross-linked hydrogels. These biocompatible, cationically, and anionically charged hydrogel materials exhibited pronounced shear-thinning behavior, making them useful for a variety of biomedical applications. For example, we investigated the antimicrobial activity of positively charged thiouronium functionalized hydrogels by microbial growth inhibition assays against several clinically relevant Gram-negative and Gram-positive bacteria. It is noteworthy that these hydrogels exhibited broad spectrum killing efficiencies approaching 100%, thereby rendering these thixotropic materials attractive for treatment of skin and other surface bound infections. Finally, cationic trimethylammonium containing hydrogels and anionic carboxylic acid functionalized hydrogels were utilized to sustain the release of negatively charged (diclofenac) and positively charged (vancomycin) therapeutics, respectively. Collectively, the present work introduces a simple method for formulating charged hydrogel materials that are capable of interacting with various analytes of interest through noncovalent interactions.
ChemInform Abstract: Oxazolinylferrocene Ligands for the Addition of Diethylzinc to Benzaldehyde: Effects of the Symmetry and the Substituent on the Oxazoline Ring of the Ligands on Asymmetric Catalysis. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Guidance on the Use of Convalescent Plasma to Treat Immunocompromised Patients With Coronavirus Disease 2019 (2023)

Coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) is a safe and effective treatment for COVID-19 in immunocompromised (IC) patients. IC patients have a higher risk of persistent infection, severe disease, and death from COVID-19. Despite the continued clinical use of CCP to treat IC patients, the optimal dose, frequency/schedule, and duration of CCP treatment has yet to be determined, and related best practices guidelines are lacking. A group of individuals with expertise spanning infectious diseases, virology and transfusion medicine was assembled to render an expert opinion statement pertaining to the use of CCP for IC patients. For optimal effect, CCP should be recently and locally collected to match circulating variant. CCP should be considered for the treatment of IC patients with acute and protracted COVID-19; dosage depends on clinical setting (acute vs protracted COVID-19). CCP containing high-titer severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies, retains activity against circulating SARS-CoV-2 variants, which have otherwise rendered monoclonal antibodies ineffective.
Hydrogel-Encapsulated Beads Enable Proximity-Driven Encoded Library Synthesis and Screening (2023)

Encoded combinatorial library technologies have dramatically expanded the chemical space for screening but are usually only analyzed by affinity selection binding. It would be highly advantageous to reformat selection outputs to ”one-bead-one-compound” solid-phase libraries, unlocking activity-based and cellular screening capabilities. Here, we describe hydrogel-encapsulated magnetic beads that enable such a transformation. Bulk emulsion polymerization of polyacrylamide hydrogel shells around magnetic microbeads yielded uniform particles (7 ± 2 μm diameter) that are compatible with diverse in-gel functionalization (amine, alkyne, oligonucleotides) and transformations associated with DNA-encoded library synthesis (acylation, enzymatic DNA ligation). In a case study of reformatting mRNA display libraries, transcription from DNA-templated magnetic beads encapsulated in gel particles colocalized both RNA synthesis via hybridization with copolymerized complementary DNA and translation via puromycin labeling. Two control epitope templates (V5, HA) were successfully enriched (50- and 99-fold, respectively) from an NNK5 library bead screen via FACS. Proximity-driven library synthesis in concert with magnetic sample manipulation provides a plausible means for reformatting encoded combinatorial libraries at scale.