gebhart/patrepeval huggingface dataset:
Covalent Structure of Bovine Neurophysin-II: Localization of the Disulfide Bonds (1972)

The completed amino-acid sequence of bovine neurophysin-II, a major neurohypophyseal hormone-binding protein in the hypothalamo-neurohypophyseal complex of cows, set the stage for the localization of the disulfide bonds of this sulfur-rich molecule. Neurophysin-II was digested with subtilisin or a pepsin-trypsin mixture. The resulting peptides were subjected to first-dimensional electrophoresis at pH 6.5, oxidized with performic acid, and subjected to second-dimensional electrophoresis under identical conditions as the first-dimensional separation, but in a perpendicular direction. Cysteic acid peptides were eluted (several after additional electrophoretic purification at pH 3.5) for amino-acid composition and NH(2)- and COOH-terminal analyses. Our assignment of the seven disulfide bridges present in neurophysin-II is as follows: Cys(10)-Cys(93); Cys(13)-Cys(95); Cys(21)-Cys(27); Cys(28)-Cys(44); Cys(54)-Cys(61); Cys(67)-Cys(73); Cys(74)-Cys(79). The assignment of disulfide bridges associated with Cys(27) and Cys(28) is tentative as it is derived from evolutionary consideration. The high disulfide content reduces drastically the allowed number of biofunctional conformers of neurophysin-II. It is suggested that neurophysin-II possesses a globular topography with minimal alpha-helix structure.
Semantical considerations on dialectical and practical commitments (2008)

This paper studies commitments in multiagent systems. A dialectical commitment corresponds to an agent taking a po-sition about a putative fact, including for the sake of argu-ment. A practical commitment corresponds to an agent being obliged to another to bring about a condition. Although com-mitments have been used in many works, an adequate formal semantics and axiomatization for them does not yet exist. This paper presents a logic of commitments that illustrates the commonalities and differences of the two kinds of com-mitments. In this manner, it generalizes the developments of previous papers, precisely delineates the meanings of com-mitments, and identifies important postulates used informally or semiformally in previous work. This paper considers “social ” commitments as introduced in
Speed-Based State-of-Charge Tracking Control for Metro Trains With Onboard Supercapacitors (2011)

This paper suggests a novel energy management control algorithm for metro trains based on speed measurement and acceleration estimation. The aim of the control is to recover in a supercapacitor (SC) storage device the maximum energy regenerated during train electrical braking and to limit the contact line peak current. The energy management control is integrated with the motor drive control, since discharge and charge of SC are connected to motoring and braking operations of the train. The algorithm is based on two nested loops on voltage and current of SC. The voltage and current references are calculated on the basis of the estimation of the train inertial force and acceleration, taking into account the power losses of the system. A simplified mathematical model of the whole electrical drive has been developed and the main features of the control strategy have been presented. Numerical simulations show the efficacy of suggested control and the energy saving obtained for metro trains. Experimental tests made on an electromechanical simulator fully confirm theoretical results.
ChemInform Abstract: Indazolylamino Quinazolines and Pyridopyrimidines as Inhibitors of the EGFr and C‐erbB‐2. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Methods and Materials from Unexpected Abundance of HLA Class II Presented Peptides in Primary Renal Cell Carcinomas (2023)

&lt;p&gt;Methods, Tables 1-3, Figures 1-4&lt;/p&gt;
Metalized polymer tubes for high-frequency electromagnetic waveguiding (2018)

Low loss electromagnetic energy transport over long distances motivates the development of different types of waveguiding systems. Requirements of high quality optically polished waveguide surfaces needed in high-frequency applications and low-cost manufacturing are practically incompatible in current realizations. Here we demonstrate a new paradigm solution, based on surface functionalization with subsequent electroless plating of conductive micron smooth copper layer on the inner surface of flexible non-conducting poly-carbonate tubes. The structure was shown to support moderately low loss guiding performances (~5-10 dB/m) at Ku-band. The mechanically flexible design of the system allows shaping the waveguide network almost on demand. In particular, an efficient energy guiding over a closed loop with 8 lambda radius was demonstrated. The new platform of high quality metalized flexible waveguiding systems opens new opportunities in designs of cheap and efficient networks, operating over a broad spectral range, approaching tens of GHz and even higher.
Unrepeatered Transmission of 400Gb/s over 557km and 100Gb/s over 590km with Single Fibre Configuration (2018)

We demonstrate unrepeatered transmission of 400Gb/s $(4\times 128Gb/s)$ over 557km and 100Gb/s over 590km distance with single fibre configuration using forward and backward ROPAs enabled by 2nd-order Raman pumping and large $A_{eff}$ ultra-low-loss fibre.
1568. Implementation of a Standard Diet Regimen for Neutropenic High-Risk Cancer Patients: Effects on Incidence of Infections, Foodborne Diseases, and Outcome (2018)

Neutropenia is a major risk factor for infections in cancer patients. Even though evidence to support a germ-free neutropenic diet (ND) is missing, many oncology departments still maintain ND regimens. While benefits of an ND remain uncertain, restrictions of food and rigorous preparation rules impact quality of life and may further increase malnutrition rates in cancer patients. Based on the Cologne Cohort of Neutropenic Patients database, we conducted a retrospective analysis of high-risk hematological/oncological patients with a confirmed period of neutropenia (neutrophils < 500/mm3) which lasted longer than 5 days. The interval of four years before and after replacing the ND by a standard hospital diet (SD) in January 2008 was compared. Patients undergoing allogenic stem-cell transplantation were excluded. The relative days of febrile neutropenia (relFN) before (neutropenic diet group, NDG) and after (standard diet group, SDG) the change of diet were analyzed in a propensity score-matched cohort. Secondary outcomes were the incidence of food borne disease, bloodstream infections (BSI), antibiotic treatment, diarrhea, weight change, nausea, and death. A total of 774 neutropenic episodes of each NDG and SDG were included into the analysis. The median days of neutropenia were 11 (IQR 8–16) in the NDG and 10 (IQR 8–16) in the SDG (P = 0.320). The rate of acute leukemia for NDG and SDG was 47% (P = 0.839). The mean relFN was 0.20 in the NDG and 0.22 in the SDG (P = 0.270). In our multivariate model, no association between diet and relFN was identified (OR 0.03; IQR −0.04–0.09; P = 0.410). Diarrhea occurred in 52% in the NDG and 40% in the SDG (P < 0.001), nausea in 72% and 66% (P < 0.001). No significant changes in frequency of gastrointestinal infections (NDG: 2; SDG: 1; P = 0.719) or BSI related to foodborne disease (NDG: 0; SDG: 3 P = 0.248) were detected after change of diet. The detected BSI (NDG: 29%; SDG: 30%; P = 0.867), antibiotic treatment (NDG: 78%; SDG: 77%; P = 0.760), weight gain (NDG: 11%; SDG: 14%; P = 0.121), and median 28-day mortality (NDG: 13.5 (IQR 8.8–32.5); SDG: 17 (IQR 10–29); P = 0.118) were equally distributed after change of diet (see Figure 1). We did not detect a change in relFN after replacing the ND with an SD. In our population, an SD was safe for neutropenic high-risk patients. All authors: No reported disclosures.
An Algorithmic Approach to the Diagnosis of Pancreatic Neoplasms (2009)

Abstract Context.—The pancreas gives rise to an array of distinct neoplasms that can be solid, cystic, or intraductal and can recapitulate the various lines of differentiation present in the normal gland. Objective.—To develop an algorithmic approach to the diagnosis of pancreatic neoplasms that simplifies their pathologic evaluation. Data Sources.—We reviewed literature related to the classification of pancreatic neoplasms on the basis of their gross, histologic, and immunohistochemical features. Conclusions.—By using a series of dichotomous decisions, the differential diagnosis of a pancreatic neoplasm can be narrowed, and in cases of the more common neoplasms, accurate classification can be achieved. Uncommon neoplasms not accounted for by this approach are also discussed, and the additional diagnostic information needed for complete pathologic reporting is presented.
Electronic Absorption Spectroscopy of Aluminum Metal Atom Hydration Products Isolated in Rare Gas Matrices at 15 K (1982)

Assignments are made for the electronic transitions corresponding to the Al metal atom, its dimer, the insertion product of Al and H2O (HAl0H), and the HAl0H photolysis products: Al0 and Al0H. Al2 shows a (0,0) transition at 4049 Å with an average Δv+½ of 252 cm-1. HA10H displays a very broad absorption with a short wavelength onset at 4000 Å tailing out to about 6300 Å. A10H has a broad absorption with a maxima at 2490 Å.
Combination Echinocandin-Polyene Treatment of Murine Mucormycosis (2008)

We previously found that caspofungin synergized with amphotericin B lipid complex in treating murine mucormycosis. We now report a similarly enhanced activity of liposomal amphotericin combined with micafungin or anidulafungin in mice with disseminated mucormycosis. The efficacy of combination echinocandin-polyene therapy for mucormycosis is a class effect.
Jagten på den ultimative læringsressource (2014)

I MONA, 2014(3), var der en spændende artikel om udviklingen og evalueringen af læringsspillet Jagten/Kampen1 om råstofferne som en organiserende ramme om elevernes møde med en udstilling på Økolariet i Vejle.
Regioselective Synthesis of Benzimidazolones via Cascade C–N Coupling of Monosubstituted Ureas (2014)

A direct method for the regioselective construction of benzimidazolones is reported wherein a single palladium catalyst is employed to couple monosubstituted urea substrates with differentially substituted 1,2-dihaloaromatic systems. In this method, the catalyst is able to promote a cascade of two discrete chemoselective C-N bond-forming processes that allows the highly selective and predictable formation of complex heterocycles from simple, readily available starting materials.
Strong Coupling between Plasmonic Gap Modes and Photonic Lattice Modes in DNA-Assembled Gold Nanocube Arrays (2015)

Control of both photonic and plasmonic coupling in a single optical device represents a challenge due to the distinct length scales that must be manipulated. Here, we show that optical metasurfaces with such control can be constructed using an approach that combines top-down and bottom-up processes, wherein gold nanocubes are assembled into ordered arrays via DNA hybridization events onto a gold film decorated with DNA-binding regions defined using electron beam lithography. This approach enables one to systematically tune three critical architectural parameters: (1) anisotropic metal nanoparticle shape and size, (2) the distance between nanoparticles and a metal surface, and (3) the symmetry and spacing of particles. Importantly, these parameters allow for the independent control of two distinct optical modes, a gap mode between the particle and the surface and a lattice mode that originates from cooperative scattering of many particles in an array. Through reflectivity spectroscopy and finite-difference time-domain simulation, we find that these modes can be brought into resonance and coupled strongly. The high degree of synthetic control enables the systematic study of this coupling with respect to geometry, lattice symmetry, and particle shape, which together serve as a compelling example of how nanoparticle-based optics can be useful to realize advanced nanophotonic structures that hold implications for sensing, quantum plasmonics, and tunable absorbers.
Characterization of the Ebola virus nucleoprotein-RNA complex (2010)

When Ebola virus nucleoprotein (NP) is expressed in mammalian cells, it assembles into helical structures. Here, the recombinant NP helix purified from cells expressing NP was characterized biochemically and morphologically. We found that the recombinant NP helix is associated with non-viral RNA, which is not protected from RNase digestion and that the morphology of the helix changes depending on the environmental salt concentration. The N-terminal 450 aa residues of NP are sufficient for these properties. However, digestion of the NP-associated RNA eliminates the plasticity of the helix, suggesting that this RNA is an essential structural component of the helix, binding to individual NP molecules via the N-terminal 450 aa. These findings enhance our knowledge of Ebola virus assembly and understanding of the Ebola virus life cycle.
Blogging Together: An Examination of Group Blogs (2009)

This paper presents the first examination of the growing phenomenon of multi-author, or group blogs. Using a large collection of blog posts gathered over an eight month period, we conducted some quantitative assessments. Multi-author blogs were found to differ significantly from single-and-two author blogs on several quality metrics, including having longer posts on average and being ranked higher according to an in-link metric. Visualization of patterns of posting revealed that individual authors often dominate the posts in multi-author blogs, and that in some cases tags are shared, but usually not extensively.
The study for fabricating two-dimensional photonic crystal by soft lithography technology and optical mensuration of superprism phenomena (2008)

Using soft lithography technology, the 2D photonic crystal superprism structures with a triangle array of air holes on the polymer slab were designed, simulated and fabricated successfully. The profile of the molded structures with 450nm in diameter and 900nm in lattice constant was obtained and observed by SEM. By means of optical experiment and measurement, when the input incident angle varied from 15&deg; to 11&deg;, we observed the beam propagation angle change from positive to negative and the superprism effect was demonstrated effectively at near-infrared wavelength 1550nm.
Attitude estimation based on multibeam antenna signal power levels (2013)

A recently developed wide angle multibeam satellite antenna enables a new method of satellite attitude determination. It is based on the estimation of the rotation and translation of given nominal signal reception points on the two-dimensional antenna array plane during attitude variations. A Least-Squares algorithm was developed solving for three satellite rotation angles around the axes in radial, cross track and along track direction.
In vitro hepatitis C virus infection and hepatic choline metabolism (2019)

Abstract Choline is an essential nutrient required for normal neuronal and muscular development, as well as homeostatic regulation of hepatic metabolism. In the liver, choline is incorporated into the main eukaryotic phospholipid, phosphatidylcholine (PC) and can enter one carbon metabolism via mitochondrial oxidation. Hepatitis C virus (HCV) is a hepatotropic positive-strand RNA virus that similar to other positive-strand RNA viruses can impact phospholipid metabolism. In the current study we sought to interrogate the link between choline transport and early HCV infection. Namely, we aimed to investigate how HCV modulates markers of choline metabolism following in vitro infection, while subsequently assessing how the inhibition of choline uptake and metabolism upon concurrent HCV infection may alter early viral replication. Finally, we assessed whether these parameters were consistent between cells cultured in fetal bovine serum (FBS) or human serum (HS), conditions known to differentially affect in vitro HCV infection. We observed that choline transport in FBS-cultured Huh7.5 cells is facilitated by the intermediate affinity transporter choline transporter-like family (CTL), and that CTL1 expression and the incorporation of choline into PC is diminished in 24 h infected FBS-cultured cells. Reciprocally, limiting the availability of choline for PC synthesis resulted in increased HCV replication at this early stage. In chronically HS-cultured Huh7.5 cells, there were no differences in the expression of choline transporters upon HCV infection or alterations to viral replication when choline transport was inhibited compared to control treatments. However, inhibiting choline uptake and metabolism in this system significantly impaired the production of infectious virions in HS-cultured cells. These results suggest that in addition to a known role of choline kinase, the transport of choline, potentially via CTL1, might also represent an important and regulated process during HCV infection. Abstract Figure
Immunotherapy to improve cognition and reduce pathological species in an Alzheimer’s disease mouse model (2018)

This study shows that acute treatment with an aβComAb can effectively improve performance in behavioral testing without reduction of amyloid plaque burden, and that peripherally administered IgG can affect levels of pathological species in the brain.
Modulated laser radar decoding by inter symbol interference (2011)

Pseudo Random Noise (PN) coded laser radar can improve the target detection ability without the demand on high power laser. However, the reflected echoes are generally so weak that they are buried in the thermal noise of the receiver, which raises the problem of choosing an optimal threshold for correctly decoding them since the power of echoes varies from time to time, and the voltage of light generated electrical signal by photo diode (PD) is always positive. In this work, we firstly show the problem we are going to discuss. Then, a novel method basing on Inter Symbol Interference (ISI) is proposed for solving the problem. Next, numerical simulations and experiments are performed to validate the method. Finally, we discuss the obtained results theoretically.
Relevance Vector Machine Learning for Neonate Pain Intensity Assessment Using Digital Imaging (2010)

Pain assessment in patients who are unable to verbally communicate is a challenging problem. The fundamental limitations in pain assessment in neonates stem from subjective assessment criteria, rather than quantifiable and measurable data. This often results in poor quality and inconsistent treatment of patient pain management. Recent advancements in pattern recognition techniques using relevance vector machine (RVM) learning techniques can assist medical staff in assessing pain by constantly monitoring the patient and providing the clinician with quantifiable data for pain management. The RVM classification technique is a Bayesian extension of the support vector machine (SVM) algorithm, which achieves comparable performance to SVM while providing posterior probabilities for class memberships and a sparser model. If classes represent "pure" facial expressions (i.e., extreme expressions that an observer can identify with a high degree of confidence), then the posterior probability of the membership of some intermediate facial expression to a class can provide an estimate of the intensity of such an expression. In this paper, we use the RVM classification technique to distinguish pain from nonpain in neonates as well as assess their pain intensity levels. We also correlate our results with the pain intensity assessed by expert and nonexpert human examiners.
Expression of Endothelial Cell Adhesion Molecules in Neovascularized Tissue (2000)

These findings indicate that endothelial cells in newly formed blood vessels exhibit a pattern of basal and cytokine-induced expression of certain adhesion glycoproteins that is similar to nonproliferating cutaneous vessels.
High-Throughput Screening of MOFs for Breakdown of V-Series Nerve Agents (2020)

Metal-organic frameworks (MOFs) have shown promise for the catalytic decomposition of chemical weapons. Finding the best materials for the degradation of nerve agents requires the ability to screen a high number of samples and elucidate the key parameters of effective catalysis. In this work, a high-throughput screening (HTS) method has been developed to evaluate MOFs as catalysts, specifically against the V-class of nerve agents. Over 100 MOFs have been tested using the V-class simulant, <i>O</i>,<i>O</i>-diethyl <i>S</i>-phenyl phosphorothioate (DEPPT), revealing good activity for some UiO-66 derivatives. A medium-throughput hydrolysis assay for the nerve agent <i>O</i>-ethyl <i>S</i>-[2-(diisopropylamino)ethyl]methylphosphonothioate (VX) was also performed using six MOFs selected from HTS and was validated by <sup>31</sup>P NMR. The results demonstrated that the DEPPT-based assay is a good indicator of V-series agent reactivity and should be considered in addition to the common (4-nitrophenyl)phosphate (DMNP) assay that is used for G-series agents.
Preparation of Composite Membrane between a Uniform Porous Silica Matrix and Injected Proton Conductive Gel Polymer (2005)

A new proton-conducting membrane was prepared consisting of uniformly macroporous silica and a proton-conducting gel polymer electrolyte. Three-dimensionally uniformly ordered macroporous silica was synthesized by use of a colloidal template method with monodisperse polystyrene beads. A macroporous silica membrane with adequate mechanical strength and porosity was successfully obtained. A gel polymer, 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), was injected into all of the pores to prepare a proton-conducting membrane that is a composite of macroporous silica and the gel polymer. The prepared membrane exhibited high proton conductivity and low methanol permeation. A H2−O2 fuel cell was constructed in order to test the composite membrane. The electrochemical performance obtained for the fuel cell with the composite membrane was similar to that for a fuel cell with a Nafion 117 membrane. From this result, it can be concluded that the composite membrane consisting of ceramic and polymer can be applied to fuel cells working at low temperature.
ChemInform Abstract: A Concise Enantioselective Synthesis of (+)‐L‐733,060 and (+)‐T‐2328 via Sequential Proline Catalysis. (2016)

Abstract (+)‐L‐733,060 (I) is obtained by an asymmetric synthesis in 6 steps with an overall yield of 32% (93% e.e.) and (+)‐T‐2328 (II) in 10 steps with 28% overall yield (93% e.e.).
Plasma enhanced in situ chamber cleaning evaluated by extracted-plasma-parameter analysis (1996)

We have demonstrated that high-efficiency in situ chamber cleaning with short gas residence time is possible for SiO/sub 2/ etching chambers by use of NF/sub 3/ plasma, and that the endpoint determination of the cleaning is possible by monitoring the optical emission intensities of CO or H. Nitrogen trifluoride (NF/sub 3/), which has a low N-F bond energy, can generate a plasma with a high density of ions and radicals featuring low kinetic energy. The cleaning efficiency of several halogenated-gas plasmas has been evaluated based on extracted-plasma-parameter analysis. In this analysis important plasma parameters, such as ion energy and ion flux density, can be extracted through a simple rf waveform measurement at the plasma excitation electrode. The accuracy of this technique has been confirmed with a newly developed rf plasma direct probing method and by ion current measurements.