gebhart/patrepeval huggingface dataset:
In-Place Learning for Positional and Scale Invariance (2006)

In-place learning is a biologically inspired concept, meaning that the computational network is responsible for its own learning. With in-place learning, there is no need for a separate learning network. We present in this paper a multiple-layer in-place learning network (MILN) for learning positional and scale invariance. The network enables both unsupervised and supervised learning to occur concurrently. When supervision is available (e.g., from the environment during autonomous development), the network performs supervised learning through its multiple layers. When supervision is not available, the network practices while using its own practice motor signal as self-supervision (i.e., unsupervised per classical definition). We present principles based on which MILN automatically develops positional and scale invariant neurons in different layers. From sequentially sensed video streams, the proposed in-place learning algorithm develops a hierarchy of network representations. The global invariance was achieved through multi-layer quasi-invariances, with increasing invariance from early layers to the later layers. Experimental results are presented to show the effects of the principles.
Abstract 4935: High-throughput immune-oncology screen identifies EGFR inhibitors as potent enhancers of CTL antigen-specific tumor cell killing (2018)

Abstract As immune checkpoint blocking antibodies increasing become foundational therapies for the treatment of cancer, there is a pressing need to identify compounds that synergize with checkpoint blockade as the basis of combinatorial treatment regimens. We have developed a screening assay in which a luciferized tumor cell line expressing a model antigen is co-cultured with a transgenic CD8+ T cell specifically recognizing the model antigen in a H-2b-restricted manner. The target tumor cell/T cell assay was screened with a small molecule library to identify compounds that inhibit or enhance T cell-mediated killing of tumor cells in an antigen-dependent manner. The EGFR inhibitor Erlotinib was the top hit that enhanced T cell killing of tumor cells. Subsequent experiments with Erlotinib and additional EGFR inhibitors validated the screen result. EGFR inhibitors increase both basal and IFN-γ-induced antigen processing and presentation of MHC class-I, which enhanced recognition and lysis by CD8+ cytotoxic T lymphocytes. The tumor cell line was also transduced to constitutively express Cas9, and a pooled CRISPR screen utilizing the same target tumor cell/T cell assay identified sgRNAs targeting EGFR as sensitizing tumor cells to T cell-mediated killing. Combination of PD-1 blockade with EGFR inhibition showed significant synergistic efficacy in the MC38 syngeneic colon cancer model that was superior to PD-1 blockade or EGFR inhibition alone, further validating EGFR inhibitors as immunomodulatory agents that enhance PD-1 checkpoint blockade. This novel target tumor cell/T cell assay can be screened in high-throughput with small molecule libraries and genome-wide CRISPR/Cas9 libraries to identify both compounds AND target genes, respectively, that enhance or inhibit T cell recognition and killing of tumor cells. Citation Format: Patrick H. Lizotte, Troy Luster, Megan E. Cavanaugh, Luke J. Taus, Abha Dhaneshwar, Naomi Mayman, Aaron Yang, Mark Bittinger, Paul Kirschmeier, Nathanael S. Gray, David A. Barbie, Pasi A. Janne. High-throughput immune-oncology screen identifies EGFR inhibitors as potent enhancers of CTL antigen-specific tumor cell killing [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4935.
RESP (2013)

Physical Unclonable Functions (PUFs) have emerged as an attractive primitive to address diverse hardware security issues in Integrated Circuits (ICs). A majority of existing PUFs rely on a dedicated circuit structure for generating chip-specific signatures, which often imposes concerns due to area/power overhead and extra design efforts. Furthermore, existing PUF-based signature generation cannot be employed to authenticate chips already in the market. In this paper, we propose RESP, a novel PUF structure realized in embedded SRAM array, a prevalent component in processors and system-on-chips (SOCs), with virtually no design modification. RESP leverages on voltage-depend memory access failures (during write) to produce large volume of high-quality challenge-response pairs. Since many modern ICs integrate SRAM array of varying size with isolated power grid, RESP can be easily retrofitted into these chips. Circuit-level simulation of 1000 chips using realistic process variation model shows high uniqueness of 49.2% average inter-die Hamming distance and good reproducibility of 2.88% intra-die Hamming distance under temperature < 85°C. The device aging effect, e.g. bias temperature instability (BTI), results in only 4.95% estimated unstable bits for ten-year usage.
A spatio-spectral polarization analysis of 1 µm-pumped bulk supercontinuum in a cubic crystal (YAG) (2018)

We present the first systematic study of the spatio-spectral polarization properties of a supercontinuum generated in a cubic crystal, yttrium–aluminum garnet (YAG), including a full spectral analysis of the white light core and surrounding ring structure. We observe no depolarization of the supercontinuum, and no spatial dependence of polarization ratios for any wavelength. We discuss the discrepancy of YAG’s polarization behavior in the context of well-established results in literature reporting self-induced depolarization in other cubic crystals.
Effects of Polyphenol Substances Derived fromTheobroma cacaoon Gastric Mucosal Lesion Induced by Ethanol (1998)

The antiulcer activity of cacao liquor water-soluble crude polyphenols (CWSP) was examined. CWSP, alpha-tocopherol, sucralfate (500 mg/kg), and cimetidine (250 mg/kg) were orally administered to male SD rats 30 minutes before ethanol treatment. 5 ml/kg of ethanol given intragastrically caused lesions in mucosa of the glandular stomach. CWSP caused a reduction of such hemorrhagic lesions as well as cimetidine and sucralfate which are typical antiulcer drugs, but alpha-tocopherol was less effective. Thiobarbituric acid reactive substances in gastric mucosa significantly increased with ethanol administration. CWSP treatment significantly reduced this change. The administration of ethanol extensively increased myeloperoxidase (MPO) but not xanthine oxidase (XOD) activity. CWSP reduced the activities of both enzymes; they were considered the main sources of oxygen radicals. According to an in vitro study, CWSP directly reducted XOD but not MPO. These results suggest that the antiulcer mechanism of CWSP was not only radical scavenging but also modulation of leukocyte function.
Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size (2019)

The underpinnings of mild to moderate neurodevelopmental delay remain elusive, often leading to late diagnosis and interventions. Here, we present data on exome and genome sequencing as well as array analysis of 13 individuals that point to pathogenic, heterozygous, mostly de novo variants in WDFY3 (significant de novo enrichment P = 0.003) as a monogenic cause of mild and non-specific neurodevelopmental delay. Nine variants were protein-truncating and four missense. Overlapping symptoms included neurodevelopmental delay, intellectual disability, macrocephaly, and psychiatric disorders (autism spectrum disorders/attention deficit hyperactivity disorder). One proband presented with an opposing phenotype of microcephaly and the only missense-variant located in the PH-domain of WDFY3. Findings of this case are supported by previously published data, demonstrating that pathogenic PH-domain variants can lead to microcephaly via canonical Wnt-pathway upregulation. In a separate study, we reported that the autophagy scaffolding protein WDFY3 is required for cerebral cortical size regulation in mice, by controlling proper division of neural progenitors. Here, we show that proliferating cortical neural progenitors of human embryonic brains highly express WDFY3, further supporting a role for this molecule in the regulation of prenatal neurogenesis. We present data on Wnt-pathway dysregulation in Wdfy3-haploinsufficient mice, which display macrocephaly and deficits in motor coordination and associative learning, recapitulating the human phenotype. Consequently, we propose that in humans WDFY3 loss-of-function variants lead to macrocephaly via downregulation of the Wnt pathway. In summary, we present WDFY3 as a novel gene linked to mild to moderate neurodevelopmental delay and intellectual disability and conclude that variants putatively causing haploinsufficiency lead to macrocephaly, while an opposing pathomechanism due to variants in the PH-domain of WDFY3 leads to microcephaly.
Practical NOMA-Based Coordinated Direct and Relay Transmission (2020)

This letter puts forth a practical non-orthogonal multiple access (NOMA)-based coordinated direct and relay transmission (CDRT) scheme, referred to as network-coded multiple access CDRT (NCMA-CDRT). We consider a two-user uplink scenario, where a near user communicates directly to a base station (BS), whereas a far user needs the assistance of a decode-and-forward relay. While prior NOMA-CDRT studies focused extensively on theoretical analysis, its superiority has not been well investigated through practical communication schemes. In particular, successive interference cancellation (SIC), a predominant NOMA decoding technique, does not work well if transmitters with comparable received powers transmit together. We investigate NCMA-CDRT to tackle this practical issue. A distinguishing feature of NCMA-CDRT is the joint use of physical-layer network coding (PNC) and multiuser decoding at both the relay and the BS. We design packet relaying strategies that can forward the PNC packets decoded at the relay to boost system throughput. Experiments on software-defined radio indicate that the total throughput of NCMA-CDRT significantly outperforms the SIC-based NOMA-CDRT. Overall, NCMA-CDRT is a viable solution for cooperative NOMA systems.
The Sunyaev‐Zeldovich Infrared Experiment: A Millimeter‐Wave Receiver for Cluster Cosmology (1997)

Measurements of the Sunyaev-Zeldovich (S-Z) effect toward distant clusters of galaxies can be used to determine the Hubble constant and the radial component of cluster peculiar velocities. Determination of the cluster peculiar velocity requires the separation of the two components of the S-Z effect, which are due to the thermal and bulk velocities of the intracluster plasma. The two components can be separated practically only at millimeter wavelengths. Measurements of the S-Z effect at millimeter wavelengths are subject to minimal astrophysical confusion and, therefore, provide an important test of results obtained at longer wavelengths. We describe the instrument used to make the first significant detections of the S-Z effect at millimeter wavelengths. This instrument employs new filter, detector, and readout technologies to produce sensitive measurements of differential sky brightness stable on long timescales. These advances allow drift-scan observations that achieve high sensitivity while minimizing common sources of systematic error.
X-ray imaging detector silicon field emission tip array energy conversion (2006)

We present here an X-ray detector based on Si field-emission tip technology. The X-ray is first converted to EHPs in the substrate Si The electrons are emitted into vacuum from spatially-distinct nanoscale field emission tips fabricated on the back-side of the conversion layer, and detected using an imaging multi-channel plate (MCP).
Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice (2015)

Phosphorylation-mediated recruitment switch of NCoR1 between nuclear receptor subsets provides a mechanism by which corepressors can selectively modulate liver energy metabolism during the fasting-feeding transition.
ChildGAN: Large Scale Synthetic Child Facial Data Using Domain Adaptation in StyleGAN (2023)

In this research work, we proposed a novel ChildGAN, a pair of GAN networks for generating synthetic boys and girls facial data derived from StyleGAN2. ChildGAN is built by performing smooth domain transfer using transfer learning. It provides photo-realistic, high-quality data samples. A large-scale dataset is rendered with a variety of smart facial transformations: facial expressions, age progression, eye blink effects, head pose, skin and hair color variations, and variable lighting conditions. The dataset comprises more than 300k distinct data samples. Further, the uniqueness and characteristics of the rendered facial features are validated by running different computer vision application tests which include CNN-based child gender classifier, face localization and facial landmarks detection test, identity similarity evaluation using ArcFace, and lastly running eye detection and eye aspect ratio tests. The results demonstrate that synthetic child facial data of high quality offers an alternative to the cost and complexity of collecting a large-scale dataset from real children.
Novel Amide-Based Chain Transfer Agent for Reversible Addition Fragmentation Chain Transfer Polymerization (2005)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTNovel Amide-Based Chain Transfer Agent for Reversible Addition Fragmentation Chain Transfer PolymerizationPittaya Takolpuckdee, Craig A. Mars, Sébastien Perrier, and Stephen J. ArchibaldView Author Information Department of Colour and Polymer Chemistry, University of Leeds, Leeds, LS2 9JT, United Kingdom, and Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, United Kingdom Cite this: Macromolecules 2005, 38, 4, 1057–1060Publication Date (Web):January 15, 2005Publication History Received25 June 2004Revised8 December 2004Published online15 January 2005Published inissue 1 February 2005https://pubs.acs.org/doi/10.1021/ma048727lhttps://doi.org/10.1021/ma048727lrapid-communicationACS PublicationsCopyright © 2005 American Chemical SocietyRequest reuse permissionsArticle Views567Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Organic compounds,Polymerization,Radical polymerization,RAFT polymerization,Styrenes Get e-Alerts
ExplorinG frailty and mild cognitive impairmEnt in kidney tRansplantation to predict biomedicAl, psychosocial and health cost outcomeS (GERAS): protocol of a nationwide prospective cohort study (2016)

This pioneering project jointly examines frailty and mild cognitive impairment from bio-psychosocial and health economic perspectives. Results may significantly inform risk prediction, care tailoring and resource optimization to improve health outcomes in the ageing kidney transplant cohort.
Human T-lymphocyte products stimulate human hemopoietic progenitor cell proliferation in diffusion chambers in vivo (1982)

Abstract Human myeloid colony formation in diffusion chambers in mice (CFU-DG) was enhanced following administration of a human T-cell-line-derived conditioned medium (Mo). The Mo cell line also elaborates activities stimulating human myeloid colony formation in vitro in agar (CSF) and potentiating erythroid colony formation in vitro in methylcellulose (EPA). Depletion of CSF from Mo conditioned medium by heat inactivation or gel exclusion chromatography did not affect CFU-DG formation. EPA and CFU-DG stimulating activities are heat stable and have approximately the same molecular weight. Culture of human bone marrow cells in diffusion chambers in mice for 4 days under the influence of Mo conditioned medium resulted in significant increment of BFU-E and CFU-DG as judged by subculture of diffusion chamber contents. No effect on CFU-C could be detected.
Click Chemistry on Solid Phase:  Parallel Synthesis of N-Benzyltriazole Carboxamides as Super-Potent G-Protein Coupled Receptor Ligands (2006)

The click chemistry-based backbone amide linker 1 was employed for an efficient and practical parallel synthesis of 1,2,3-triazole carboxamides when 1,3-dipolar cycloaddition was exploited for both the construction of a compound library and the functionalization of the resin. A three-step solid-phase-supported sequence included reductive amination by N-phenylpiperazinyl-substituted alkylamines, N-acylation by alkynoic acids, and azide-alkyne [3 + 2] cycloaddition. In most cases, cleavage under acidic conditions yielded the final products in excellent purities. A focused library of 60 target compounds was screened for G-protein coupled receptor binding employing eight biogenic amine receptors. Radioligand displacement experiments indicated a number of hit compounds revealing excellent receptor recognition when the methyl-substituted N-benzyltriazoles 29, 40, and 42 exhibited superior affinities for the alpha1 subtype (K(i) = 0.056-0.058 nM).
Recurrent neural network language model adaptation for multi-genre broadcast speech recognition (2015)

Copyright © 2015 ISCA. Recurrent neural network language models (RNNLMs) have recently become increasingly popular for many applications including speech recognition. In previous research RNNLMs have normally been trained on well-matched in-domain data. The adaptation of RNNLMs remains an open research area to be explored. In this paper, genre and topic based RNNLMadaptation techniques are investigated for a multi-genre broadcast transcription task. A number of techniques including Probabilistic Latent Semantic Analysis, Latent Dirichlet Allocation and Hierarchical Dirichlet Processes are used to extract show level topic information. These were then used as additional input to the RNNLM during training, which can facilitate unsupervised test time adaptation. Experiments using a state-of-theart LVCSR system trained on 1000 hours of speech and more than 1 billion words of text showed adaptation could yield perplexity reductions of 8% relatively over the baseline RNNLM and small but consistent word error rate reductions.
Supergroups of eukaryotes through a biotechnologist’s look. The system of eukaryotes and the need for a taxonomic/biotechnological interface (2022)

Eukaryotes represent a group of rich biotechnological potential, and its classification having high heuristic power and great predictive capabilities is needed by the biotechnological community. The requirements for biological classification by applied sciences can be reduced to 1) the stability of the classification system and 2) its adequacy to the nature relationships. The present paper provides a retrospective review of eukaryotic megataxonomy, assesses the stability of current system, and outlines approaches to building an interface that ensures a crosstalk of taxonomic and biotechnological communities.
Electron backscatter in X-ray tubes: experiment and analysis (2003)

X-ray medical imaging techniques use 80-140 kV X-ray tubes running at increasingly high power levels (52 kW instantaneous) to generate high quality images with low exposure times. X-rays are generated at <1% efficiency in the anode, with the balance of the input power converted to heat. In addition to radiative and conduction heat transport, it is necessary to explicitly consider electron backscatter (EBS) as an independent heat transfer mechanism for design of the highest power X-ray tubes. Here we discuss EBS physics and X-ray tube aspects, describe experimental measurement of spatially resolved EBS current in a high power demountable X-ray tube system and obtain a good comparison with numerical analysis of EBS current distribution.
High Speed Machining of Titanium Alloys (2009)

Removal rates for machining titanium alloys are an order of magnitude slower than those for aluminum. The high strength and hardness coupled with the relatively low elastic modulus and poor thermal conductivity of titanium contribute to the slow speeds and feeds that are required to machine titanium with acceptable tool life. Titanium has extremely attractive properties for air vehicles ranging from excellent corrosion resistance to good compatibility with graphite reinforced composites and very good damage tolerance characteristics. At current Buy to Fly ratios, the F-35 Program will consume as much as seven million pounds of titanium a year at rate production. This figure is nearly double that of the F-22 Program, which has a much higher titanium content. As much as 50% of the final cost of titanium parts can be attributed to machining. Specifically, in this task, we are working to improve the material removal rate of titanium to reduce cost. Lockheed Martin is evaluating the potential to use lasers to heat the material ahead of the tool to reduce its strength. Coupled with other technologies that can improve the tool life and prevent the titanium material from welding to the tool, there is hope for a practical solution using similar milling machines to those which exist today, if not a simple retro-fit option. This presentation will present the current progress of this project and its potential impact to the Joint Strike Fighter.
Laparoscopic Cyst Decortication in Autosomal Dominant Polycystic Kidney Disease: Impact on Pain, Hypertension, and Renal Function (2003)

For ADPKD patients with debilitating pain, extensive LCD can provide durable relief. In the majority of patients with pain and hypertension, a marked improvement in blood pressure also occurs. Cyst decortication was not associated with worsening renal function; indeed, renal function remained largely unchanged over the 3-year follow-up period.
Joint Pilot Sequence Design and Power Control for Max-Min Fairness in\n Uplink Massive MIMO (2017)

This paper optimizes the pilot assignment and pilot transmit powers to\nmitigate pilot contamination in Massive MIMO (multiple-input multiple-output)\nsystems. While prior works have treated pilot assignment as a combinatorial\nproblem, we achieve a more tractable problem formulation by directly optimizing\nthe pilot sequences. To this end, we compute a lower bound on the uplink (UL)\nspectral efficiency (SE), for Rayleigh fading channels with maximum ratio (MR)\ndetection and arbitrary pilot sequences. We optimize the max-min SE with\nrespect to the pilot sequences and pilot powers, under power budget\nconstraints. This becomes an NP-hard signomial problem, but we propose an\nefficient algorithm to obtain a local optimum with polynomial complexity.\nNumerical results manifest the near optimality of the proposed algorithm and\nshow significant gains over existing suboptimal algorithms.\n