gebhart/patrepeval huggingface dataset:
Metabolic, Health and Lifestyle Profiling of Breast Cancer Radiotherapy Patients and the Risk of Developing Fatigue (2012)

Background: Fatigue is commonly reported by cancer patients. In some instances it can persist after treatment is completed. In order to develop effective treatment strategies it is important to understand the mechanisms underlying the development of fatigue and to be able to predict those that may be at greatest risk of experiencing fatigue during and following treatment. The current paper examines predisposing factors for fatigue including altered fatty acid homeostasis in a cohort of breast cancer radiotherapy patients. Methodology: Patients had undergone breast-conserving surgery and adjuvant breast irradiation. Prior to radiotherapy the patients were free from significant fatigue. Levels of fatigue were determined prior to and following radiotherapy using the Functional Assessment of Cancer Therapy fatigue subscale. Plasma fatty acid levels, urinary and plasma amino acid levels, blood biochemistry factors and general health and lifestyle characteristics were assessed. Results: Following radiotherapy, significant fatigue affected approximately one third of the 26 patients and these subjects were then assigned to the fatigued cohort. Univariate analysis revealed that higher levels of the fatty acids myristic acid and eicosadienoic acid were present for the fatigued cohort prior to radiotherapy. Multivariate analysis also revealed that fatty acid homeostasis was altered between the fatigued and non-fatigued groups at baseline. Orthogonal partial least squares discriminant analysis of the general health, lifestyle and metabolic data revealed that the fatigued and non-fatigued patients could be clustered into two clearly separate groups. Conclusions: The results supported the proposition that the fatigued patients had an underlying metabolic homeostasis which may predispose them to the development of fatigue. Biochemical and general health profiling of breast cancer patients has the potential to identify those at most risk of developing significant fatigue following radiotherapy.
Humidification in a Modified Circle System (1979)

An improved circle system, capable of delivering high inspiratory humidity from the onset of anesthesia, was made by introducing a water vaporizer into the soda lime canister and tested on a model patient. Vaporization was facilitated by the exothermic reaction of neutralization of the lime. Humidity loss due to rain out in the absorber and inspiratory limb was minimized by constructional alterations of the absorber circuit assembly: (1) the conduit pipe which leads the moist absorber gases into the inspiratory limb was moved from its conventional outside position to the warm interior of the lime canister; (2) the moisture-laden fresh gases emerging from the vaporizer were delivered close to the patient by a small bore tube placed concentrically inside the inspiratory limb; and (3) both the fresh and inspired gases were thermally insulated by an outermost, moist, warm coaxial expiratory limb. The humidity output of the circuit was high 1 minute after starting ventilation, averaging 19.6 ± 2, 19.3 ± 2.9, and 19 ± 1.1 mg of H2O/L as carbon dioxide output was increased by 100-ml increments from 100 to 300 ml/min (using fresh gas inflow of 5 L/min and a ventilatory minute volume of 6 L/min). After a 2- to 3-hour period of stabilization, humidity reached 22.8 ± 1.5, 24 ± 0.9, and 28 ± 2.4 mg of H2O/L at the carbon dioxide flows quoted above. Vaporizer patent held by Albert Einstein College of Medicine, Bronx, NY (circuit patent pending).
Frequency-locked, quasiperiodic, and chaotic motions of current-density filaments in a semiconductor device (1996)

Silicon multilayered devices biased with a dc voltage exhibit spontaneous voltage oscillations which are connected with spatial, pendulumlike oscillations of a current-density filament. When driven with a superimposed sinusoidal voltage, the oscillations of the device voltage show frequency locking, quasiperiodicity, and chaos. In order to correlate the global voltage oscillations with the filament motion spatially resolved measurements of the filament dynamics have been performed by using two different techniques: measurements of the recombination radiation with a streak camera and measurements of the potential on the device surface between the electrical contacts with an active potential probe. The experimental results clearly reveal that the various kinds of voltage oscillations are caused by corresponding frequency-locked, quasiperiodic, or chaotic filament motions. \textcopyright{} 1996 The American Physical Society.
Integer-Wise Functional Bootstrapping on TFHE: Applications in Secure Integer Arithmetics (2021)

TFHE is a fast fully homomorphic encryption scheme proposed by Chillotti et al. in Asiacrypt’ 2018. Integer-wise TFHE is a generalized version of TFHE that can encrypt the plaintext of an integer that was implicitly presented by Chillotti et al., and Bourse et al. presented the actual form of the scheme in CRYPTO’ 2018. However, Bourse et al.’s scheme provides only homomorphic integer additions and homomorphic evaluations of a sign function. In this paper, we construct a technique for operating any 1-variable function in only one bootstrapping of the integer-wise TFHE. For applications of the scheme, we also construct a useful homomorphic evaluation of several integer arithmetics: division, equality test, and multiplication between integer and binary numbers. Our implementation results show that our homomorphic division is approximately 3.4 times faster than any existing work and that its run time is less than 1 second for 4-bit integer inputs.
Closed-Loop Insulin Delivery Utilizing Pole Placement to Compensate for Delays in Subcutaneous Insulin Delivery (2011)

Insulin feedback provides an effective mechanism to compensate for delay in the insulin PK/PD profile.
Sequence‐Selective DNA Recognition with Peptide–Bisbenzamidine Conjugates (2013)

Transcription factors (TFs) are specialized proteins that play a key role in the regulation of genetic expression. Their mechanism of action involves the interaction with specific DNA sequences, which usually takes place through specialized domains of the protein. However, achieving an efficient binding usually requires the presence of the full protein. This is the case for bZIP and zinc finger TF families, which cannot interact with their target sites when the DNA binding fragments are presented as isolated monomers. Herein it is demonstrated that the DNA binding of these monomeric peptides can be restored when conjugated to aza-bisbenzamidines, which are readily accessible molecules that interact with A/T-rich sites by insertion into their minor groove. Importantly, the fluorogenic properties of the aza-benzamidine unit provide details of the DNA interaction that are eluded in electrophoresis mobility shift assays (EMSA). The hybrids based on the GCN4 bZIP protein preferentially bind to composite sequences containing tandem bisbenzamidine-GCN4 binding sites (TCAT⋅AAATT). Fluorescence reverse titrations show an interesting multiphasic profile consistent with the formation of competitive nonspecific complexes at low DNA/peptide ratios. On the other hand, the conjugate with the DNA binding domain of the zinc finger protein GAGA binds with high affinity (KD≈12 nM) and specificity to a composite AATTT⋅GAGA sequence containing both the bisbenzamidine and the TF consensus binding sites.
Physiologically Plausible Stochastic Nonlinear Kernel Models of Spike Train to Spike Train Transformation (2006)

Nonlinear kernel models are developed and estimated for the spike train transformation from hippocampal CA3 region to CA1 region. The physiologically plausible model structure consists of nonlinear feedforward kernels that model synaptic transmission and dendritic integration, a linear feedback kernel that models spike-triggered after potential, a threshold, an adder, and a noise term that assesses the system uncertainties. Model parameters are estimated using maximum-likelihood method. Model goodness-of-fit is evaluated using correlation measures and time-rescaling theorem. First order, linear model is shown to be insufficient. Second and third order nonlinear models can successfully predict the output spike distribution
Wearable Electrocutaneous Feedback System: A Smart Device to Compensate for Sensation Loss (2012)

Frontiers Abstracts Wearable Electrocutaneous Feedback System: A Smart Device to Compensate for Sensation Loss Jan Walter Schroeder, Jan Walter Schroeder Search for other works by this author on: This Site PubMed Google Scholar Venketesh N Dubey, Venketesh N Dubey Smart Technology Research Centre, School of Design, Search for other works by this author on: This Site PubMed Google Scholar Tamas Hickish, Tamas Hickish Smart Technology Research Centre, School of Design,Engineering & Computing, Bournemouth UniversityRoyal Bournemouth Hospital Search for other works by this author on: This Site PubMed Google Scholar Jonathan Cole Jonathan Cole Poole Hospital Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information Venketesh N Dubey Smart Technology Research Centre, School of Design, Tamas Hickish Smart Technology Research Centre, School of Design,Engineering & Computing, Bournemouth UniversityRoyal Bournemouth Hospital Jonathan Cole Poole Hospital J. Med. Devices. Mar 2012, 6(1): 017515 (1 pages) https://doi.org/10.1115/1.4026693 Published Online: March 12, 2012 Article history Received: May 27, 2011 Revision Received: November 7, 2011
A Focused Microarray for Screening Rat Embryonic Stem Cell Lines (2012)

Here, we describe a focused microarray for screening rat embryonic stem cells (ESCs) and provide validation data that this array can distinguish undifferentiated rat ESCs from rat trophoblast stem (TS) cells, rat extraembryonic endoderm cells, mouse embryonic fibroblast feeder cells, and differentiated rat ESCs. Using this tool, genuine rat ESC lines, which have been expanded in a conventional rat ESC medium containing two inhibitors (2i), for example, glycogen synthase kinase 3 (GSK3) and mitogen-activated protein kinase (MEK) inhibitors, and leukemia inhibitory factor, and genuine rat ESCs, which have been expanded in rat ESC medium containing four inhibitors (4i), for example, GSK3, MEK, Alk5, and Rho-associated kinase inhibitors were compared; as were genuine rat ESCs from 4 different strains of rats. Expression of Cdx2, a gene associated with trophoblast determination, was observed in genuine, undifferentiated rat ESCs from 4 strains and from both 2i and 4i ESC derivation medium. This finding is in contrast to undifferentiated mouse ESCs that do not express Cdx2. The rat ESC focused microarray described in this report has utility for rapid screening of rat ESCs. This tool will enable optimization of culture conditions in the future.
Practical guidance for engaging patients in health research, treatment guidelines and regulatory processes: results of an expert group meeting organized by the World Health Organization (WHO) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) (2019)

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients' needs. However, there is currently little guidance on how meaningful patient engagement may be achieved. An expert working group, representing a wide range of stakeholders and disciplines, was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the World Health Organization (WHO). Through a structured, collaborative process the group generated practical guidance to facilitate optimal patient engagement in clinical development and regulatory decisions. Patient engagement is a relational process. The principles outlined in this report were based on lessons learned through applied experience and on an extensive dialogue among the expert participants. This practice guidance forms a starting point from which tailoring of the approach to suit different chronic diseases may be undertaken.
Targeting neuropilin-1 to inhibit prostate cancer invasion and metastasis (2015)

Recent reports provide evidence that the epithelial-to-mesenchymal transition (EMT) plays a key role in prostate cancer (PCa) metastasis and therapy resistance. We have recently identified the cell surface receptor, Neuropilin-1 (NRP1) to be increased during epithelial-mesenchymal transition (EMT) and this study aims to determine whether the inhibition of NRP1 will be a feasible therapeutic strategy for blocking PCa metastasis and therapy resistance.
Frequency Offset Estimation in a Polarization-Multiplexed Coherent OFDM system stressed by chromatic dispersion and PMD (2012)

We propose here a simple method to estimate carrier frequency offset (CFO) in a polarization-multiplexed coherent OFDM (CO-OFDM) system. Compared to existing techniques, this method based on the determination of the shifted position of the last filled OFDM sub-carrier (located just before the zero or empty sub-carriers area) permits to easily compensate large CFO, while not affecting the system robustness when facing chromatic dispersion, first and second order PMD.
PROX1 transcription factor controls rhabdomyosarcoma growth, stemness, myogenic properties and therapeutic targets (2022)

Rhabdomyosarcoma (RMS) is an aggressive pediatric soft-tissue cancer with features of skeletal muscle. Because of poor survival of RMS patients and severe long-term side effects of RMS therapies, alternative RMS therapies are urgently needed. Here we show that the prospero-related homeobox 1 (PROX1) transcription factor is highly expressed in RMS tumors regardless of their cell type of origin. We demonstrate that PROX1 is needed for RMS cell clonogenicity, growth and tumor formation. PROX1 gene silencing repressed several myogenic and tumorigenic transcripts and transformed the RD cell transcriptome to resemble that of benign mesenchymal stem cells. Importantly, we found that fibroblast growth factor receptors (FGFR) mediated the growth effects of PROX1 in RMS. Because of receptor cross-compensation, paralog-specific FGFR inhibition did not mimic the effects of PROX1 silencing, whereas a pan-FGFR inhibitor ablated RMS cell proliferation and induced apoptosis. Our findings uncover the critical role of PROX1 in RMS and offer insights into the mechanisms that regulate RMS development and growth. As FGFR inhibitors have already been tested in clinical phase I/II trials in other cancer types, our findings provide an alternative option for RMS treatment.
Line‐Drawing Video Stylization (2015)

Abstract We present a method to automatically convert videos and CG animations to stylized animated line drawings. Using a data‐driven approach, the animated drawings can follow the sketching style of a specific artist. Given an input video, we first extract edges from the video frames and vectorize them to curves. The curves are matched to strokes from an artist's library, while following the artist's stroke distribution and characteristics. The key challenge in this process is to match the large number of curves in the frames over time, despite topological and geometric changes, allowing to maintain temporal coherence in the output animation. We solve this problem using constrained optimization to build correspondences between tracked points and create smooth sheets over time. These sheets are then replaced with strokes from the artist's database to render the final animation. We evaluate our tracking algorithm on various examples and show stylized animation results based on various artists.
The conclusion of expert meeting "New treatment perspectives of community-acquired pneumonia and bacterial sinusitis" (2007)

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Effective bandwidths in a priority queueing system with leaky bucket regulated traffic sources (2002)

A new admission control algorithm is proposed in this paper for traffic streams controlled by a dual leaky bucket enforcing on the one hand, the peak rate with a stringent tolerance, and on the other hand, the mean rate with a given a bucket size. The proposed algorithm relies on a model, which stochastically dominates the theoretical system composed of deterministic worst case traffic sources multiplexed in a finite capacity queue. Assuming that there are N source types characterized by the traffic parameter sets (_i,_i,_i), i = 1, , N, this dominating model is the M^[X]/M/1/K system, where input batch Poisson process is the superposition of N batch Poisson processes; the ith batch Poisson process is composed of batches of size _i arriving at rate _i/_i. We derive effective bandwidths for both the M^[X]/M/1/K system with heterogeneous traffic and the M^[X]/M/1/K system including a head of line priority level. In the former case, the effective bandwidth obtained by using the M^[X]/M/1/K system is compared with other effective bandwidths, which have been proposed earlier in the literature for ATM networks. It turns out that the proposed effective bandwidth definition leads to similar results but has the advantage of yielding admissibility regions delimited by hyper-planes. In the latter case, for the numerical values considered for the bucket sizes and the buffer capacities- , the effective bandwidths, which rely on exact upper bounds, are very close to those obtained by using the so-called reduced service rate approximation. This rigorously justifies a posteriori that approximation.
HOL-Z 2.0: A Proof Environment for Z-Specifications (2002)

Abstract: We present a new proof environment for the specification language Z. The basis is a semantic representation of Z in a structure-preserving, shallow embedding in Isabelle/HOL. On top of the embedding, new proof support for the Z schema calculus and for proof structuring are developed. Thus, we integrate Z into a well-known and trusted theorem prover with advanced deduction technology such as higher-order rewriting, tableaux-based provers and arithmetic decision procedures. A further achievement of this work is the integration of our embedding into a new toolchain providing a Z-oriented type checker, documentation facilities and macro support for refinement proofs; as a result, the gap has been closed between a logical embedding proven correct and a tool suited for applications of non-trivial size.
Evaluation of Commercial Resolution Recovery Techniques in Four State-of-the-art Single Photon Emission Computed Tomography Systems Using a Digital Phantom Model (2012)

An SI needs more than 150 to obtain an accurate compensation effect. As for the advance method, the major compensation effect was not demonstrated very much as compared with the OS-EM. The EVL, FL3, and AST overestimated values due to a Gibb's oscillation in the artifacts of the conical part.
Recombination Mechanisms in Ga-free Type-II Superlattices and Alloys. (2013)

Abstract not provided.
Complementary silicon MESFETs for VLSI (1986)

The dominant device used in modern VLSI circuits today is the MOS transistor. As technology has advanced several limitations of MOSFETs have become apparent: hot electron effects with their associated threshold voltage shifts, short channel effects, and also the practical technological problems of shrinking junctions and growing high integrity, low defect, thin gate oxides. MESFETs do not require thin gate oxides and hence are not susceptible to the problems of obtaining reliable thin gate oxides or to threshold voltage shifts due to hot carriers. Also, MESFETs are best suited to low voltage operation which is a common feature of most advanced VLSI technologies. In addition, MESFET devices have been shown to be quite radiation hard compared to other technologies. Finally, the MESFET can achieve bulk carrier mobility whereas MOSFETs are often restricted to less than half this value due to their surface conduction. The limited use of MESFETs for VLSI in the past has been due in part to their power requirements and limited variety of circuit configurations. The development of a complementary MESFET process not only reduces their power requirement and increases circuit flexibility, but also results in an improved speed performance thus improving their viability for VLSI applications.
Data from <i>In Vivo</i> Modeling of CLL Transformation to Richter Syndrome Reveals Convergent Evolutionary Paths and Therapeutic Vulnerabilities (2023)

&lt;div&gt;Abstract&lt;p&gt;Transformation to aggressive disease histologies generates formidable clinical challenges across cancers, but biological insights remain few. We modeled the genetic heterogeneity of chronic lymphocytic leukemia (CLL) through multiplexed &lt;i&gt;in vivo&lt;/i&gt; CRISPR-Cas9 B-cell editing of recurrent CLL loss-of-function drivers in mice and recapitulated the process of transformation from indolent CLL into large cell lymphoma [i.e., Richter syndrome (RS)]. Evolutionary trajectories of 64 mice carrying diverse combinatorial gene assortments revealed coselection of mutations in &lt;i&gt;Trp53&lt;/i&gt;, &lt;i&gt;Mga&lt;/i&gt;, and &lt;i&gt;Chd2&lt;/i&gt; and the dual impact of clonal &lt;i&gt;Mga&lt;/i&gt;/&lt;i&gt;Chd2&lt;/i&gt; mutations on E2F/MYC and interferon signaling dysregulation. Comparative human and murine RS analyses demonstrated tonic PI3K signaling as a key feature of transformed disease, with constitutive activation of the AKT and S6 kinases, downmodulation of the PTEN phosphatase, and convergent activation of MYC/PI3K transcriptional programs underlying enhanced sensitivity to MYC/mTOR/PI3K inhibition. This robust experimental system presents a unique framework to study lymphoid biology and therapy.&lt;/p&gt;Significance:&lt;p&gt;Mouse models reflective of the genetic complexity and heterogeneity of human tumors remain few, including those able to recapitulate transformation to aggressive disease histologies. Herein, we model CLL transformation into RS through multiplexed &lt;i&gt;in vivo&lt;/i&gt; gene editing, providing key insight into the pathophysiology and therapeutic vulnerabilities of transformed disease.&lt;/p&gt;&lt;p&gt;&lt;i&gt;&lt;a href="https://aacrjournals.org/bloodcancerdiscov/article/doi/10.1158/2643-3230.BCD-4-2-ITI" target="_blank"&gt;This article is highlighted in the In This Issue feature, p. 101&lt;/a&gt;&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Inside Cover: Green‐Solvent‐Processed Molecular Solar Cells (Angew. Chem. Int. Ed. 52/2014) (2014)

The careful choice of chemical structures allows the fabrication of high-performance molecular solar cells by solution deposition of molecular semiconductors from the green solvent 2-MeTHF. In their Communication on page 14378 ff., G. C. Bazan and co-workers demonstrate the relevance of these findings within the context of sustainability, the need to replace toxic substances for mass production, and the overall evaluation of various emerging photovoltaic technologies.