gebhart/patrepeval huggingface dataset:
Suspension postcolumn reaction detection method for liquid chromatography (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSuspension postcolumn reaction detection method for liquid chromatographyDouglas T. Gjerde and James V. BensonCite this: Anal. Chem. 1990, 62, 6, 612–615Publication Date (Print):March 15, 1990Publication History Published online1 May 2002Published inissue 15 March 1990https://pubs.acs.org/doi/10.1021/ac00205a014https://doi.org/10.1021/ac00205a014research-articleACS PublicationsRequest reuse permissionsArticle Views39Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Plane-wave vector-flow imaging of adult mouse heart (2018)

High-frequency ultrasound Doppler modes have been used extensively for murine cardiovascular (CV) studies, but traditional linear-array imaging modes are limited in terms of spatial and temporal resolution. Plane-wave imaging methods allow for high-speed vector-flow information to be obtained throughout a full image frame. Plane-wave imaging has been demonstrated in human CV studies, but its use in mouse models has received minimal attention. A Verasonics Vantage with an 18-MHz linear array was used to acquire plane-wave data at a frame rate of 30 kHz from the left ventricle of adult mice. Batches of 3 transmissions spanning ± 5 degrees were sent out. The mouse was placed supine on a heated imaging platform and then 2D + time data sequences. The data were beamformed using standard delay-and-sum methods and vector-flow estimates were obtained at each pixel location using a least-squares, multi-angle Doppler analysis approach. Vortex patterns in the left ventricle were visualized over several heart cycles showing the complex flow in the mouse heart.
Table S1 from Intertumoral Heterogeneity of CD3<sup>+</sup> and CD8<sup>+</sup> T-Cell Densities in the Microenvironment of DNA Mismatch-Repair–Deficient Colon Cancers: Implications for Prognosis (2023)

&lt;p&gt;Table S1. Inter-tumor heterogeneity of T-cell densities in tumor microenvironment in dMMR vs pMMR stage III colon cancers&lt;/p&gt;
Low-complexity systolic V-BLAST architecture (2009)

In multiple-input multiple-output systems, an ordered successive interference canceller, termed the vertical Bell laboratories layered space-time (V-BLAST) algorithm, offers good performance. This letter presents a low-complexity V-BLAST scheme suited for parallel implementation. The proposed scheme, using a greedy ordering, can achieve a performance comparable to that of V-BLAST with optimum ordering, while its computational complexity is lower than a linear detector.
The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects (2016)

Our findings have identified a novel strategy to reduce the N-Myc oncoprotein expression and a novel therapeutic approach for the treatment of aggressive neuroblastoma. Clin Cancer Res; 22(10); 2534-44. ©2016 AACR.
Multi-layer path calculation element considering physical impairments (2010)

A path calculation element that calculates the routes for hierarchical electrical and optical paths is proposed. It responds actively to the physical impairments so that the end-to-end performance of IP traffic is ensured.
Optical Properties Characterization of CZTSe Thin Film Solar Cells (2013)

Cu2ZnSnSe4 (CZTSe) thin films have recently been raising interest as a basis for thin film solar cells that can provide a high conversion efficiency, thanks to its direct band gap characteristics and high absorption coefficient. In order to improve the efficiency of such devices by reducing the optical losses, we have developed a methodology to build an efficient model for the simulation of the optical properties of CZTSe-CdS-ZnO based solar cells. As a first step, the layers are characterized separately in order to extract their complex refractive index (n,k). Flat layers such as CdS and ZnO are characterized using ellipsometry, while the rough CZTSe layers are analyzed using reflection &amp; transmission measurements. The extracted optical parameters are then used as inputs in a multilayer plane-wave based simulation software. The simulation results are compared to the experimental reflection and transmission spectra and showed a very good match.
Experimental Demonstration of Model Predictive Control in a Medium-Sized Commercial Building (2014)

This paper presents the implementation and experimental demonstration results of a practically effective and computationally efficient model predictive control (MPC) algorithm used to optimize the energy use of the heating, ventilation, and air-conditioning (HVAC) system in a multi-zone medium-sized commercial building. Advanced building control technologies are key enablers for intelligent operations of future buildings, however, adopting these technologies are quite difficult in practice mainly due to the cost-sensitive nature of the building industry. This paper presents the results of implementing optimization-based control algorithm and demonstrates the effectiveness of its energy-saving feature and improved thermal comfort along with lessons-learned. The performance of the implemented MPC algorithm was estimated relative to baseline days (heuristic-based control) with similar outdoor air temperature patterns during the cooling and shoulder seasons (September to November, 2013), and it was concluded that MPC reduced the total electrical energy consumption by more than 20% on average while improving thermal comfort in terms of temperature and maintaining similar zone CO2 levels.
ECG-gated blood-pool study of carotid arterial pulsation as a sign of stenosis: concise communication. (1983)

The large elastic arteries, such as the carotids, pulsate (expand and contract) in synchrony with the heart beat. These pulsations should be reduced by significant stenosis. This hypothesis was studied in 15 men by obtaining sequential ECG-gated labeled blood-pool images of these vessels in anterior and lateral oblique views. These were computer processed by a functional program that displays each pixel with an intensity proportional to its change in activity level during the cardiac cycle. Blank areas indicated lack of pulsation and were correlated with angiographic studies. The blank skip areas were present when there was 50% or greater narrowing in arterial diameter (94% sensitivity) but were not seen in patients with normal or minimally diseased vessels (25% or less narrowing). They were present inconsistently in the four vessels with 25 to 50% narrowing.
Transistor optimization for leakage power management in a 65 nm CMOS technology for wireless and mobile applications (2004)

This paper presents a transistor optimization methodology tailored for wireless, digital consumer, and mobile applications that employ power management circuit techniques. This methodology is applied to a 65nm technology that supports a high-density (<0.5 um/sup 2/) embedded 6T SRAM cell. High performance logic (I/sub dn//I/sub dp/ = 550/300uA/um at L/sub poly/ = 39nm) and low leakage are achieved simultaneously by employing a data retention mode for the SRAM (I/sub leakage/ /spl sim/2pA/bit). Retention mode bias conditions and selective gate sizing in the SRAM reduces leakage by /spl sim/300X. Advanced transistor design including SSR channel, strain engineering, drain-extension (HDD) offset spacer, and HDD and halo profile optimization is used to achieve at least an additional 4/spl times/ reduction in leakage.
Nitrenes (2003)

This chapter contains sections titled: Introduction Alkylnitrenes Carbonylnitrenes and Related Acylnitrenes Vinylnitrenes Phenylnitrene and Simple Derivatives Polycyclic Arylnitrenes Polynitrenes Amino- and Oxonitrenes Phosphinidines Conclusion and Outlook Suggested Reading References
Ginsenosides from the Leaves and Flower Buds of Panax ginseng and their Pharmacological Effects (2012)

Ginseng, an ancient and famous herbal drug in oriental traditional medicine, has been used as a valuable tonic and for the treatment of various diseases. In medicinal purpose, ginseng root is used more common than aerial parts such as leaves and flower buds although extracts from ginseng aerial parts also contain similar active ingredients having pharmacological functions. This article reviews the purification of thirty four ginsenosides (1-34) from ginseng leaves and flower buds and their pharmacological effects. Ginsenosides are structurally classified into protopanaxadiol (PPD) and protopanaxatriol (PPT) types depending on their aglycones. The anti-oxidant activity of PPD-type ginsenosides like Rb1, Rd, Rc, and Rh2 was more active than that of PPT-type ginsenosides. Moreover, the presence of hydroperoxy in ginsenoside molecule was important for the intracellular reactive oxygen species (ROS) scavenging activity of ginsenosides. It became evident that ginsenoside F1 (8), ginsenoside F5 (9) and floralginsenoside Ta (21) remarkably inhibited the growth of HL-60 cells via the apoptosis pathway. Ginsenoside I (33) displayed potent inhibitory effect on IL-12 p40 production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) with IC50 of 6.7 μM although floralginsenoside Kc (20) and floralginsenoside J (29) showed moderate effects. Ginsenoside F1 (8), a major ginsenoside of ginseng leaves, and notoginsenosie R1 (5) significantly decreased contraction by 35 ± 3.4% and by 53 ± 1.1% at 10 μM, respectively. Floralginsenoside Kc (20), a new ginsenoside from flower-buds, showed positive inotropic effect. Keywords: Ginseng, Panax ginseng, aerial part, ginsenoside, anti-oxidant activity, cytotoxic activity, anti-inflammatory activity, myocyte contraction, cardiac contraction, pharmacological effect, protopanaxadiol, protopanaxatriol.
Visco-elastic finite difference modeling of shallow seismic data: Formation of near-surface waveguides (1995)

Waveguides are formed in grossly layered media bounded by strong physical
property contrasts. In ocean acoustics, the formation of shallow
water waveguides is known to have a significant impact on wave propagation
(Brekhovskikh and Lysanov, 1991). We suggest that similar waveguides
may exist near the solid earth's surface and investigate the effects
of such waveguides on high-resolution shallow seismic data.
Proposed enhancement of RFID data standards within the UK library sector (2016)

Implementation of RFID technology within the library sector has taken great strides forward over the last decade. ISO 28560 is a recent international standard aimed at providing a common platform to an industry that has initially evolved with a number of implementers formulating their own RFID data storage models. Previous work has highlighted shortcomings in the new standards These shortcomings include the lack of any method to circumvent data sniffing nor any practical method of ensuring data integrity. Data sniffing is a noteable area of concern and one of the barriers to adoption of library RFID technologies. This paper addresses the shortcomings in the standard and makes proposals for future improvements and revision of the standard.
Mechanistic insights into the inhibition of prostate specific antigen by β‐lactam class compounds (2007)

Prostate Specific Antigen (PSA) is a biomarker used in the diagnosis of prostate cancer and to monitor therapeutic response. However, its precise role in prostate carcinogenesis and metastasis remains largely unknown. A number of studies arguing in the favor of an active role of PSA in prostate cancer development and progression have implicated this serine protease in the release and activation of growth factors such as insulin-like growth factor 1 (IGF1) through cleavage of insulin like growth factor binding protein 3 and Transforming Growth Factor beta (TGF-beta) through cleavage of Latent TGF-beta. In contrast, other studies suggest that PSA activity might hinder tumor development and progression. In light of these contradictory findings, efficient inhibitors of PSA are needed for exploring its biological role in tumor development and metastasis. Towards the goal of developing potent inhibitors of PSA, we have explored the molecular mechanism of a series of beta-lactam based compounds on binding to PSA using activity assays, matrix assisted laser desorption ionization with a time-of-flight mass spectrometry, and GOLD docking methodology. The mass spectrometry experiments and the activity assays confirmed the time-dependent and covalent nature of beta-lactam binding. To gain insights on the reaction intermediates at the molecular level, we docked beta-lactam inhibitors to a homology modeled PSA using the GOLD docking program in noncovalent and covalent binding modes. The docking studies elucidated the molecular details of the early noncovalent Michaelis complex, the acyl-enzyme covalent complex, and the nature of conformational reorganization required for the long term stability of the covalent complex. Additionally, the molecular basis for the effect of stereochemistry of the lactam ring on the inhibitory potency was elucidated through docking of beta-lactam enantiomers. As a validation of our docking methodology, two novel enantiomers were synthesized and evaluated for their inhibitory potency using fluorogenic substrate based activity assays. Additionally, cis enantiomers of eight beta-lactam compounds reported in a previous study were docked and their GOLD scores and binding modes were analyzed in order to assess the general applicability of our docking results. The close agreement of our docking results with the experimental data validates the mechanistic insights revealed through the docking studies and paves the way for the design and development of potent and specific inhibitors of PSA.
4.3 A programmable sub-nanosecond time-gated 4-tap lock-in pixel CMOS image sensor for real-time fluorescence lifetime imaging microscopy (2017)

Fluorescence-based time-resolved (TR) analysis techniques are fundamental and effective methods in life science and medicine. Among others, fluorescence lifetime imaging microscopy (FLIM) is one of the representative measurement techniques for biomedical applications. Recently, advanced all-solid-state imaging devices for FLIM, e.g., a CCD with optional electron-multiplication (EM) readout, a single-photon avalanche diode (SPAD), and a TR CMOS image sensor (CIS), have been reported [1-3]. These devices can be implemented compactly in comparison with the typical FLIM systems such as a time-correlated single-photon counting (TCSPC) system [4]. However, imaging devices based on the CCD or SPAD still have some issues, including the need for specialized fabrication processes, use of higher voltages, and greater circuit complexity. The recent TR CIS with two taps in a pixel [3] shows us a way to realize real-time lifetime imaging, but the two-tap CIS has a limitation that a sample's lifetime cannot be measured in real time if the sample has multi-exponential decay components. This paper presents a sub-nanosecond time-gated four-tap lock-in pixel CIS using in-pixel pulse generator (PG) for fluorescence lifetime (FLT) imaging system. To realize a real-time FLT measurement system, good low-noise performance and the capability for fast data acquisition are essential. Thus, a lateral electric field charge modulator (LEFM) implemented with in-pixel PG block, 2-stage chargetransfer technique for true correlated double sampling (CDS) operation, and multi-tap design are used for the developed lock-in pixel. Additionally, a narrow time-window (TW) generated in pixel-level PG helps to attain the high signal-tonoise ratio (SNR) FLT measurement results.
Enantioselective Synthesis of PPAR (Peroxisome Proliferator-Activated Receptors) Agonists and Antagonists (2014)

This review deals with stereoselective issues in PPAR ligands some of which are in clinical use for treating certain metabolic disorders. After a short introduction of these nuclear receptor and their agonists, some cases of enantioselective separations are reported. The main part concerns stereoselective synthesis first starting with asymmetric synthesis from chiral precursors followed by what we refer to as "true" enantioselective methods. Some examples are discussed in detail for each particular heading.
Genetic Variants on 3q21 and in the Sp8 Transcription Factor Gene (SP8) as Susceptibility Loci for Psychotic Disorders: A Genetic Association Study (2013)

We found 3p21.1 (including PBRM1, strong linkage disequilibrium made it difficult to pinpoint the risk genes) and SP8 as risk loci for BD, SCZ and psychosis. Further replication studies will be required for conclusive results.
Synaptic reshaping of plastic neuronal networks by periodic multichannel stimulation with single-pulse and burst stimuli (2022)

Synaptic dysfunction is associated with several brain disorders, including Alzheimer's disease, Parkinson's disease (PD) and obsessive compulsive disorder (OCD). Utilizing synaptic plasticity, brain stimulation is capable of reshaping synaptic connectivity. This may pave the way for novel therapies that specifically counteract pathological synaptic connectivity. For instance, in PD, novel multichannel coordinated reset stimulation (CRS) was designed to counteract neuronal synchrony and down-regulate pathological synaptic connectivity. CRS was shown to entail long-lasting therapeutic aftereffects in PD patients and related animal models. This is in marked contrast to conventional deep brain stimulation (DBS) therapy, where PD symptoms return shortly after stimulation ceases. In the present paper, we study synaptic reshaping by periodic multichannel stimulation (PMCS) in networks of leaky integrate-and-fire (LIF) neurons with spike-timing-dependent plasticity (STDP). During PMCS, phase-shifted periodic stimulus trains are delivered to segregated neuronal subpopulations. Harnessing STDP, PMCS leads to changes of the synaptic network structure. We found that the PMCS-induced changes of the network structure depend on both the phase lags between stimuli and the shape of individual stimuli. Single-pulse stimuli and burst stimuli with low intraburst frequency down-regulate synapses between neurons receiving stimuli simultaneously. In contrast, burst stimuli with high intraburst frequency up-regulate these synapses. We derive theoretical approximations of the stimulation-induced network structure. This enables us to formulate stimulation strategies for inducing a variety of network structures. Our results provide testable hypotheses for future pre-clinical and clinical studies and suggest that periodic multichannel stimulation may be suitable for reshaping plastic neuronal networks to counteract pathological synaptic connectivity. Furthermore, we provide novel insight on how the stimulus type may affect the long-lasting outcome of conventional DBS. This may strongly impact parameter adjustment procedures for clinical DBS, which, so far, primarily focused on acute effects of stimulation.
Ethics of Social Research (2006)

As society develops, it is important to keep ethical problems under continuing scrutiny and debate. It should also be recognized that a productive balance is between societyâ€™s need for knowledge and its memberâ€™s need for protection against intrusion, inconvenience, or discomfort. Freedom of enquiry must be balanced against the rights of privacy. While the issues are complex, accommodation and resolution are possible.
Quantitative Serum Glycomics of Esophageal Adenocarcinoma, and Other Esophageal Disease Onsets (2009)

Aberrant glycosylation has been implicated in various types of cancers and changes in glycosylation may be associated with signaling pathways during malignant transformation. Glycomic profiling of blood serum, in which cancer cell proteins or their fragments with altered glycosylation patterns are shed, could reveal the altered glycosylation. We performed glycomic profiling of serum from patients with no known disease (&lt;i&gt;N&lt;/i&gt; = 18), patients with high grade dysplasia (HGD, &lt;i&gt;N&lt;/i&gt; = 11) and Barrett’s esophagus (&lt;i&gt;N&lt;/i&gt; = 5), and patients with esophageal adenocarcinoma (EAC, &lt;i&gt;N&lt;/i&gt; = 50) in an attempt to delineate distinct differences in glycosylation between these groups. The relative intensities of 98 features were significantly different among the disease onsets; 26 of these correspond to known glycan structures. The changes in the relative intensities of three of the known glycan structures predicted esophageal adenocarcinoma with 94% sensitivity and better than 60% specificity as determined by receiver operating characteristic (ROC) analysis. We have demonstrated that comparative glycomic profiling of EAC reveals a subset of glycans that can be selected as candidate biomarkers. These markers can differentiate disease-free from HGD, disease-free from EAC, and HGD from EAC. The clinical utility of these glycan biomarkers requires further validation.
Low cost, electronically steered phased array for general aviation (1990)

This paper describes a multifaced, phased array antenna developed for general aviation satellite communications applications. The antenna design satisfies all INMARSAT Aeronautical SDM requirements. Unique features of this antenna include an integral LNA and diplexer, integral phase shifters which are shared among the array faces, a serial beam steering interface and low manufacturing cost.
Anatomy and Dimensions of the Gluteus Medius Tendon Insertion (2008)

Gluteus medius tendon tears can be a source of significant pain and morbidity. This study describes the anatomic morphology of this tendon insertion, which should aid in its repair when necessary.