gebhart/patrepeval huggingface dataset:
Synthesis of Stereoisomers and Isoforms of a Tryptic Heptapeptide Fragment of Human Growth Hormone and Analysis by Reverse‐Phase HPLC and Capillary Electrophoresis (1996)

The amino acid sequence Asn-Gly has at pH 7 a tendency to induce deamidation of asparagine to aspartic acid via the formation of a cyclic imide. This imide opens up to yield Asp-Gly or the isoaspartic acid (isoAsp) form, isoAsp-Gly. Both isomers may be found in their L-form or D-form. Like Asn-Gly, the sequence Asp-Gly has a tendency for isomerization and racemization via the formation of a cyclic imide intermediate. When human growth hormone is digested with trypsin, one of the fragments is a heptapeptide (amino acid residues 128-134) containing the amino acid sequence Asp-Gly (amino acid residues 130 and 131). This heptapeptide, as well as stereoisomers and isoforms where L-Asp was replaced by D-Asp, L-isoAsp, D-isoAsp or the L-cyclic imide, respectively, has been synthesized and used as a standard to achieve separation of the five forms by capillary electrophoresis and by reverse-phase HPLC. Capillary electrophoresis analysis was performed in uncoated capillaries by the use of aspartic acid/cyclodextrin buffers at low pH. The elution order of the aspartic-acid-containing heptapeptides was D-Asp, L-Asp, L-isoAsp, D-isoAsp and L-cyclic imide. Reverse-phase HPLC analysis was performed on a C18 column by the use of a shallow acetonitrile gradient in trifluoroacetic acid/water. The elution order was D-isoasp, L-isoASp, L-Asp, D-Asp and L-cyclic imide. Human growth hormone samples were degraded by incubation at high temperature and analyzed for their potential content of isomerization and racemization products. Only L-forms of aspartic acid and isoaspartic acid of the heptapeptide fragment were found.
A Thieno[3,4-c]pyrrole-4,6-dione-Based Donor−Acceptor Polymer Exhibiting High Crystallinity for Photovoltaic Applications (2010)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTA Thieno[3,4-c]pyrrole-4,6-dione-Based Donor−Acceptor Polymer Exhibiting High Crystallinity for Photovoltaic ApplicationsMao-Chuan Yuan, Mao-Yuan Chiu, Shih-Pin Liu, Chia-Min Chen, and Kung-Hwa Wei*View Author Information Department of Materials Science and Engineering, National Chiao Tung University, 30049 Hsinchu, Taiwan, ROC*Corresponding author. E-mail: [email protected]Cite this: Macromolecules 2010, 43, 17, 6936–6938Publication Date (Web):August 16, 2010Publication History Received8 July 2010Revised4 August 2010Published online16 August 2010Published inissue 14 September 2010https://pubs.acs.org/doi/10.1021/ma101523ahttps://doi.org/10.1021/ma101523arapid-communicationACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views3697Altmetric-Citations142LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Energy levels,Layers,Photovoltaics,Polymers,Solar cells Get e-Alerts
A 2-order MIMO full-duplex antenna system (2014)

The paper presents an antenna system with combined full-duplex and 2-order multiple-input-multiple-output (MIMO) functionalities, i.e., a system capable of spatially multiplexing and spatially demultiplexing 2 datastreams in the same frequency and in the same time. By exploiting symmetries in the construct and the feed, simple corrective beamforming weights can be applied at the transmitter (Tx) ports in order to selectively cancel the Tx signal at the receiver (Rx) ports, thus guaranteeing a large amount of isolation necessary for full-duplex (i.e., simultaneous and in-band Tx and Rx) operation. On the other hand, the 2 MIMO ports (either at the Tx or at the Rx) are sufficiently decoupled thanks to polarization diversity. The proposed antenna system exhibits a remarkable level of full-duplex isolation over a wide bandwidth while maintaining low coupling between its MIMO ports and can serve as a concrete implementation of an antenna system equipped with both MIMO as well as full-duplex capabilities.
Abstract 10571: Causes of Early Mortality After Catheter Ablation of Ventricular Tachycardia in Patients With Reduced Left Ventricular Ejection Fraction (2022)

Background: Recognition of the causes of early mortality after ventricular tachycardia (VT) ablation in patients with reduced left ventricular ejection fraction is an essential step toward improving post-procedural outcomes. Objective: This study sought to determine the causes of early mortality (≤30-days) after VT ablation in patients with reduced left ventricular ejection fraction and to understand further the circumstances surrounding death after the procedure. Methods: We performed a retrospective analysis of all patients undergoing VT ablation in patients with reduced left ventricular ejection fraction from January 1, 2013, to November 10, 2021, at the Mayo Clinic (Rochester, Phoenix, and Jacksonville). Causes of death were identified through a detailed chart review of the electronic health record within the Mayo Clinic system and outside records. Results: A total of 503 patients (mean age 63 ± 13 years, 11.2% female) with EF &lt;50% were included in the study. The 30-day all-cause mortality rate was 5% (n=25), and the mortality rate due to a procedural complication was 0.4%. Among all 30-day deaths, recurrent VT was the most common primary cause of death (44%). This was followed by decompensated heart failure (28%), procedure-related death (8%), cerebrovascular accident (CVA) (4%), and infection (4%). Most patients (91%) who died from VT had the VT recurrence within three days of the ablation. 76% of patients with early mortality had delayed referral for VT ablation, and 72% opted for comfort care before death. Conclusions: The overall early mortality (≤30-days) rate after catheter ablation of VT in patients with reduced left ventricular ejection fraction was 5%, but the death rate directly due to a procedural complication was only 0.4%. The most common cause of death was recurrent VT, followed by heart failure. Further research into ablation strategies is vital to improving the safety, efficacy, and durability of VT ablation.
Relationships between EUV resist outgassing and contamination deposition at Selete (2011)

This presentation summarizes the relationships between resist outgassing and contamination deposition for EUV resists, in the case of EUV irradiation with high illumination intensity (&gt;100mW/cm<sup>2</sup>). These relationships were obtained by determining the resist outgassing species by gas chromatography-mass spectroscopy (GC-MS) and the contamination on optical elements by witness sample testing.
A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B‐cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5 (1998)

B-cell chronic lymphocytic leukemia (B-CLL) is a human hematological neoplastic disease often associated with the loss of a chromosome 13 region between RB1 gene and locus D13S25. A new tumor suppressor gene (TSG) may be located in the region. A cosmid contig has been constructed between the loci D13S1168 (WI9598) and D13S25 (H2-42), which corresponds to the minimal region shared by B-CLL associated deletions. The contig includes more than 200 LANL and ICRF cosmid clones covering 620 kb. Three cDNAs likely corresponding to three different genes have been found in the minimally deleted region, sequenced and mapped against the contigged cosmids. cDNA clone 10k4 as well as a chimeric clone 13g3, codes for a zinc-finger domain of the RING type and shares homology to some known genes involved in tumorigenesis (RET finger protein, BRCA1) and embryogenesis (MID1). We have termed the gene corresponding to 10k4/13g3 clones LEU5. This is the first gene with homology to known TSGs which has been found in the region of B-CLL rearrangements.
Should we Let Citizens Decide? (2011)

Many democratic ideals assume capable participants and fair decision-making. But are citizens politically competent? Do they make wise decisions, or are they likely to pursue impractical or misguided courses of action? By examining three cases in which citizens played an unprecedented policymaking role, valuable insights were offered into the general question of whether or not the people can be trusted with their own government. In this concluding chapter, the findings and the theoretical lessons they inspire are reviewed. It is also argued that certain adjustments of the citizen assembly model should be considered in future implementations.
The influence of simulated microgravity on the proteome of Daphnia magna (2015)

The affected biological processes were also described in other studies using different organisms and systems either aiming to simulate microgravity conditions or providing real microgravity conditions. Moreover, most of the <i>Daphnia</i> protein sequences are well-conserved throughout taxa, indicating that the response to altered gravity conditions in <i>Daphnia</i> follows a general concept. Data are available via ProteomeXchange with identifier PXD002096.
J0220203 Ground Reaction Force of Ants in Locomotion on Level Ground, Vertical Wall and Ceiling (2014)

This paper reports on measurement of ground reaction forces (GRFs) of ant legs during running on level ground, vertical wall and ceiling. Micro force plate array is designed and fabricated to measure anterior and vertical directional forces. Thus, GRF of all legs in the various ground angles can be detected simultaneously. The size and force resolution are 2000 μm × 1000 μm × 20 μm and 1 μN, respectively. The measurement results show that ants use different GRF distribution in three types of terrestrial locomotion. In every types of locomotion, the ant was affected by the gravity reaction force, which was totally equal to the body weight. The gravity reaction force was approximately equal to each leg during running on level ground and ceiling. The gravity reaction force during ceiling was thought to be generated by the adhesion force of sub-micron scale hairs on the tip of the legs. The measured GRF distribution clarified that ants use the different strategies of running mechanism depending on the angle of the ground against the horizon plane.
Crystal Structure at 1.1 Å Resolution of α-Conotoxin PnIB:  Comparison with α-Conotoxins PnIA and GI (1997)

Conotoxins are small, cysteine-rich peptides isolated from the venom of Conus spp. of predatory marine snails, which selectively target specific receptors and ion channels critical to the functioning of the neuromuscular system. alpha-Conotoxins PnIA and PnIB are both 16-residue peptides (differing in sequence at only two positions) isolated from the molluscivorous snail Conus pennaceus. In contrast to the muscle-selective alpha-conotoxin GI from Conus geographus, PnIA and PnIB block the neuronal nicotinic acetylcholine receptor (nAChR). Here, we describe the crystal structure of PnIB, solved at a resolution of 1.1 A and phased using the Shake-and-Bake direct methods program. PnIB crystals are orthorhombic and belong to the space group P212121 with the following unit cell dimensions: a = 14.6 A, b = 26.1 A, and c = 29.2 A. The final refined structure of alpha-conotoxin PnIB includes all 16 residues plus 23 solvent molecules and has an overall R-factor of 14.7% (R-free of 15.9%). The crystal structures of the alpha-conotoxins PnIB and PnIA are solved from different crystal forms, with different solvent contents. Comparison of the structures reveals them to be very similar, showing that the unique backbone and disulfide architecture is not strongly influenced by crystal lattice constraints or solvent interactions. This finding supports the notion that this structural scaffold is a rigid support for the presentation of important functional groups. The structures of PnIB and PnIA differ in their shape and surface charge distribution from that of GI.
Highly integrated Active Dual Response Filter (2015)

This work focuses on the design of a novel compact Active Dual Response Filter within a single device which allows ensuring the coexistence of three different standards while proposing an optimal structure in terms of response and space. The proposed filter is based on a highly selective low-pass filter at which a highly integrated compact notch filter is coupled. This co-integration of both filters is not a cascade so that the dual response filter occupies the same area as the low-pass filter alone. The Notch filter is set to 700 MHz and is loaded by an Active Capacitor (AC) circuit that allows a rejection at the notch central frequency of at least 19 dB. The low-pass filter cut-off frequency is Fc =890 MHz, the in band return loss is better than 20 dB. This methodology can be extended to various shapes of filter functions.
Global Age-Specific Patterns of Cyclic Gene Expression Revealed by Tunicate Transcriptome Atlas (2020)

Abstract Expression levels of circadian clock genes, which regulate 24-hour rhythms of behavior and physiology, have been shown to change with age. However, a study holistically linking aging and circadian gene expression is missing. Using the colonial chordate Botryllus schlosseri , we combined transcriptome sequencing and stem cell-mediated aging phenomena to test how circadian gene expression changes with age. This revealed that B. schlosseri clock and clock-controlled genes oscillate organism-wide, with daily, age-specific amplitudes and frequencies. These age-related, circadian patterns persist at the tissue level, where dramatic variations in cyclic gene expression of tissue profiles link to morphological and cellular aging phenotypes. Similar cyclical expression differences were found in hundreds of pathways associated with known hallmarks of aging, as well as pathways that were not previously linked to aging. The atlas we developed points to alterations in circadian gene expression as a key regulator of aging. One Sentence Summary The Ticking Clock: Systemic changes in circadian gene expression correlates with wide-ranging phenotypes of aging
Age 85+ Years Accelerates Large-Fiber Peripheral Nerve Dysfunction and Diabetes Contributes Even in the Oldest-Old: The Women's Health and Aging Study (2001)

Age is strongly associated with decrements in large-fiber peripheral nerve function in disabled women aged 65+ years, with greatly accelerated risk among those aged 85+ years. Despite the overwhelmingly strong effects of advancing age on PND in this cohort, diabetes remains a significant correlate of PND. Future studies may determine whether prevention or control of diabetes is effective in reducing the occurrence of PND in old age and whether a reduction in PND will translate into reduced disability in this age group.
Explicit CM-theory in dimension 2 (2009)

Abstract. For a complex abelian surface A with endomorphism ring isomorphic to the maximal order in a quartic CM-field K, the Igusa invariants j1(A), j2(A), j3(A) generate an abelian extension of the reflex field of K. In this paper we give an explicit description of the Galois action of the class group of this reflex field on j1(A), j2(A), j3(A). We give a geometric description which can be expressed by maps between various Siegel modular varieties. We can explicitly compute this action for ideals of small norm, and this allows us to improve the CRT method for computing Igusa class polynomials. Furthermore, we find cycles in isogeny graphs for abelian surfaces, thereby implying that the ‘isogeny volcano ’ algorithm to compute endomorphism rings of ordinary elliptic curves over finite fields does not have a straightforward generalization to computing endomorphism rings of abelian surfaces over finite fields. 1.
On Designing PUF-Based TRNGs with Known Answer Tests (2018)

Random numbers are widely used in cryptographic algorithms and protocols. A faulty true random number generator (TRNG) may open a door into a system in spite of cryptographic protection. It is therefore important to design TRNGs so that they can be tested at different stages of their lifetime to assure their trustworthiness. In this paper, we propose a method for designing physical unclonable function (PUF)-based TRNGs which can be tested in-field by known answer tests. We present a prototype FPGA implementation of the proposed TRNG based on an arbiter PUF which passes all NIST 800-22 statistical tests and has the minimal entropy of 0.918 estimated according to NIST 800-90B recommendations. This is a nontrivial achievement given that arbiter PUFs are notoriously hard to place in a symmetric manner in FPGAs.
Response to Hypothetical Social Scenarios in Individuals with Traumatic Brain Injury Who Present Inappropriate Social Behavior: A Preliminary Report (2013)

RESULTS suggest that the TBI-ISB participants were likely to endorse an ISB despite being able to anticipate a negative emotional response in themselves or others, suggesting that there were other explanations for their poor behavior. A self-reported likely response to hypothetical social scenarios can be a useful approach for studying the neurocognitive processes behind the poor choices of individuals with TBI-ISB, but the task needs further validation studies. A comprehensive discussion follows on the underlying mechanisms affecting social behaviors after a TBI.
Doğrusal Sürekli Mıknatıslı Senkron Motorun Doğrusal Olmayan Manyetik Eşdeğer Devre ve Sonlu Elemanlar Tabanlı Tasarımı (2018)

Doğrusal motorlar, dişli kutusu gibi ekstra aktarma elemanlarına olan ihtiyacı ortadan kaldırdığı için özellikle otomasyon uygulamalarında sıklıkla kullanılmaktadır. Bu çalışmada bir sürekli mıknatıslı doğrusal senkron motorun (SMDSM) basit bir otomasyon uygulaması için 2-boyutlu (2B) Gauss-Siedel tabanlı doğrusal olmayan manyetik eşdeğer devre (MED) modeli oluşturulmuş ve hava aralığı, stator dişleri gibi kritik bölgelerdeki akı yoğunlukları hesaplanmıştır. Analitik olarak yapılan hesaplamalar ile zıt elektromotor kuvveti (EMK) gerilimi ve çıkış kuvveti elde edilmiştir. Son olarak motorun detaylı sonlu elemanlar analizi (SEA) gerçekleştirilerek MED modeli ve SEA sonuçlarının karşılaştırması yapılmıştır.
Synthesis, Characterization, and Catalytic Activity of Mesostructured Titanosilicates Assembled from Polymer Surfactants with Preformed Titanosilicate Precursors in Strongly Acidic Media (2003)

Novel mesostructured titanosilicates designated as MTS-9 have been successfully synthesized from assembly of preformed nanosized titanosilicate precursors with polymer surfactants. Mesoporous MTS-9 shows highly hydrothermal stability in boiling water (over 120 h) as compared with that of Ti−MCM-41 and SBA-15. In phenol hydroxylation, Ti−MCM-41 shows very low catalytic activity (2.5%), but MTS-9 exhibits very high catalytic activity, with phenol conversion of 26%, which is comparable with TS-1. In styrene epoxidation, MTS-9 shows high activity and selectivity similar to those of TS-1, which are much different from those of Ti−MCM-41. In 2,3,6-trimethylphenol hydroxylation, Ti−MCM-41 is inactive because of the relatively low oxidation ability of Ti species in the amorphous wall of Ti−MCM-41, and TS-1 is also inactive because of the inaccessibility of the small micropores of TS-1 to the large diameter of a bulky molecule like 2,3,6-trimethylphenol. However, MTS-9 is very active for this reaction with conversion of 18.8% indicating that MTS-9 is an effective catalyst for the oxidation of bulky molecules. The MTS-9 samples were characterized with infrared, UV−visible, UV−Raman, and numerous other techniques. The results suggest that the titanium species in MTS-9 are TS-1-like, and that the pore walls of MTS-9 contains primary and secondary structural building units, similar to those of microporous zeolites. Such unique structural features might be responsible for the observed strong oxidation ability and high hydrothermal stability of the mesostructured titanosilicates. Heating MTS-9 at 500 °C leads to the transformation of titanium species, giving relatively low catalytic conversion in phenol hydroxylation, which suggests that increasing thermal stability of titanium sites like TS-1 species in the mesoporous wall is still a great task for preparation of mesostructured titanosilicates.
Supplementary Figure 1 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity (2023)

&lt;p&gt;PDF file - 4112KB, Competitive internalization assay of 20nM immunotoxins with different concentration of the Her2/neu ECD on BT474 M1 cells.&lt;/p&gt;
YbRh2Si2: Pronounced Non-Fermi-Liquid Effects above a Low-Lying Magnetic Phase Transition (2000)

We report the first observation of non-Fermi-liquid (NFL) effects in a clean Yb compound at ambient pressure and zero magnetic field. The electrical resistivity and the specific-heat coefficient of high-quality single crystals of YbRh(2)Si(2) present a linear and a logarithmic temperature dependence, respectively, in more than a decade in temperature. We ascribe this NFL behavior to the presence of (presumably) quasi-2D antiferromagnetic spin fluctuations related to a very weak magnetic phase transition at T(N) approximately 65 mK. Application of hydrostatic pressure induces anomalies in the electrical resistivity, indicating the stabilization of magnetic order.
The Community and the Crowd: Multimedia Benchmark Dataset Development (2012)

The MediaEval Multimedia Benchmark leveraged community cooperation and crowdsourcing to develop a large Internet video dataset for its Genre Tagging and Rich Speech Retrieval tasks.
Electroluminescence from a conjugated polymer microcavity structure (1995)

We report the observation of electroluminescence and photoluminescence from microcavity structures containing poly(2,5-dialkoxy-p-phenylene vinylene) (PDAOPV) conjugated polymer emitting regions. Strong spectral narrowing from 112 nm full width half-maximum to 34 nm in electroluminescence and from 128 to 16 nm in photoluminescence and clear angular dependence of the peak emission wavelength are observed. These are characteristic signatures of the modification of spontaneous emission properties in microcavity structures.