gebhart/patrepeval huggingface dataset:
Correction. Generalized Rank Annihilation Method Using Similarity Transformations (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrection. Generalized Rank Annihilation Method Using Similarity TransformationsShousong. Li, J. Craig. Hamilton, and Paul J. GemperlineCite this: Anal. Chem. 1993, 65, 11, 1647Publication Date (Print):June 1, 1993Publication History Published online13 September 2004Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/ac00059a600https://doi.org/10.1021/ac00059a600research-articleACS PublicationsRequest reuse permissionsArticle Views38Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Carnosine and Diabetic Nephropathy (2019)

Diabetic Nephropathy (DN) is a major complication in patients with type 1 or type 2 diabetes and represents the leading cause of end-stage renal disease. Novel therapeutic approaches are warranted. In view of a polymorphism in the carnosinase 1 gene CNDP1, resulting in reduced carnosine degradation activity and a significant DN risk reduction, carnosine (β-alanyl-L-histidine) has gained attention as a potential therapeutic target. Carnosine has anti-inflammatory, antioxidant, anti-glycation and reactive carbonyl quenching properties. In diabetic rodents, carnosine supplementation consistently improved renal histology and function and in most studies, also glucose metabolism. Even though plasma half-life of carnosine in humans is short, first intervention studies in (pre-) diabetic patients yielded promising results. The precise molecular mechanisms of carnosine mediated protective action, however, are still incompletely understood. This review highlights the recent knowledge on the role of the carnosine metabolism in DN.
Triple-Slot Phase-Shifting Cell Loaded with Capacitances for Reflectarray Applications (2013)

Abstract — This paper presents a new phase-shifting cell topology for reflectarray. It consists of a symmetrical set of three parallel rectangular slots loaded with a combination of variable and fixed capacitances to provide four uniformly-distributed phase states with a large bandwidth. Two different slot lengths are combined to improve the bandwidth. The cell is characterized in C-band using the waveguide simulation approach. I.
Detection of Yersinia pestis fraction 1 antigen with a fiber optic biosensor (1995)

A fiber optic biosensor was used to detect the fraction 1 (F1) antigen from Yersinia pestis, the etiologic agent of plague. The instrument employs an argon ion laser (514 nm) to launch light into a long-clad fiber and measures the fluorescence produced by an immunofluorescent complex formed in the evanescent wave region. This sensing area is a short section (12.5 cm) at the end of the optical fiber from which the cladding has been removed and in which the silica core has been tapered. Capture antibodies, which bind to F1 antigen, were immobilized on the core surface to form the basis of the sandwich fluoroimmunoassay. The ability to detect bound F1 antigen was provided by adding tetramethylrhodamine-labeled anti-plaque antibody to form fluorescent complexes. The evanescent wave has a limited penetration depth (< 1 lambda), which restricts detection of the fluorescent complexes bound to the fiber's surface. The direct correlation between the F1 antigen concentration and the signal provided an effective method for sample quantitation. This method achieved a high level of accuracy for determining F1 antigen concentrations from 50 to 400 ng/ml in phosphate-buffered saline, serum, plasma, and whole blood, with a 5-ng/ml limit of detection. Subsequent blind studies, which included serum samples from patients, yielded results in good agreement with measurements by enzyme-linked immunosorbent assay. A major advantage of the fiber optic biosensor is that results can be generated within minutes while isolating the user from hazardous samples. These factors favor development of this biosensor into a facile and rapid diagnostic device.
OpenCilk (2023)

This paper presents OpenCilk, an open-source software infrastructure for task-parallel programming that allows for substantial code reuse and easy exploration of design choices in language abstraction, compilation strategy, runtime mechanism, and productivity-tool development.
Reduction of Crosstalk by Quasi-Homogeneous Solid Multi-Core Fiber (2010)

Power-conversion efficiency reduction on a quasi-homogeneous solid multi-core fiber is numerically investigated. The fiber length dependence of measured crosstalk of fabricated fibers is in good agreement of simulation result by power-coupled equation.
Experimental Demonstration of Localization on a Quantum Information Processor (2005)

Quantum computers will be a unique tool for understanding complex quantum systems. We report an experimental implementation of a sensitive, quantum coherence-dependent localization phenomenon on a prototype of a quantum computer, a quantum information processor (QIP). The localization effect is demonstrated by simulating the dynamics of the quantum sawtooth map on a three qubit liquid state nuclear magnetic resonance (NMR) device. The degree to which the system is delocalized by experimental noise and decoherence is well accounted for by a previously determined error model for NMR QIPs. We further show how the stability of the localization effect provides a benchmark of practical relevance for determining the overall degree of coherent quantum control and for identifying the relative significance of different noise mechanisms affecting the system.
Mixed-Domain Galerkin's Method for Tensor-Volume Integral Equation Using Legendre Polynomial Expansion and Efficient (2006)

In this paper, an integral equation approach with a new solution method is used to obtain external scattered fields and internal induced fields inside a dielectric body in two different cases. In one case, the dielectric object is illuminated by a plane wave and in the other case; it is located in close proximity of a thin-wire antenna. Cubic block modeling and the tensor-volume integral equation (TVIE) are adopted for the former case and a system of coupled tensor-volume/line integral equations is applied for the situation of a thin-wire antenna adjacent to a dielectric scatterer in the latter problem. In this case, the reduced kernel integral equation with piecewise sinusoidal function is used for the analysis of the thin-wire antenna. These problems have been previously investigated with an efficient Galerkin-based formulation using combined entire-domain and subdomain expansion using three-dimensional power polynomial basis functions, which has been recently introduced in our works [1] and [2]. It was shown that a compromise between accuracy and efficiency is achieved that by combining the entire-domain and subdomain basis functions [3]. As an improvement, in this article, we apply a modified Legendre polynomial basis function [4], [5] which leads to a almost orthogonal expansion of the unknown polarization current inside the dielectric body. This basis function is derived from orthogonal Legendre polynomial, which is modified to impose the continuity condition of the currents between neighboring elements. This allows the use of high-order basis functions without introducing ill-conditioning of the resulting MoM matrix [4]. Also, an integral degree reduction method is applied to reduce the numerical integration complexity. Numerical results verify the accuracy of the method and confirm the condition number of the MoM matrix obtained with this new basis is much lower than 3D power polynomial function used in [1] and [2].
The difficult proximal humerus fracture: tips and techniques to avoid complications and improve results. (2007)

The indications and techniques for surgical management of fractures of the proximal humerus remain controversial, and the results of treatment are often disappointing, with a relatively high complication rate. Anatomic reduction can be difficult, and loss of fixation because of poor bone quality may lead to fracture displacement and malunion. Hemiarthroplasty has a high rate of shoulder stiffness, tuberosity resorption, and glenohumeral instability. There is a wide variety of surgical techniques and implants to treat these fractures, but there is little guidance in the literature on specific indications for their use. Therefore, it is important for orthopaedic surgeons to be familiar with techniques to avoid complications and improve results when treating proximal humerus fractures.
Human leucocyte glycosylasparaginase is an α/β-heterodimer of 19 kDa α-subunit and 17 and 18 kDa β-subunit (1994)

Human lysosomal glycosylasparaginase (AGA; EC 3.5.1.26) consists of two glycosylated subunits, alpha and beta. Treatment with 3% SDS at 45 degrees C as part of a new purification scheme did not affect enzyme activity, but the alpha-subunit migrated an apparent 19 kDa peptide on SDS/PAGE instead of as a 24 kDa peptide, as observed without this SDS treatment. The N-terminal sequence was similar to that of the 24 kDa form, and, after reversed-phase h.p.l.c., the 19 kDa form was transformed to an apparent 24 kDa peptide on SDS/PAGE, indicating that their primary structures were identical. As the molecular mass of the alpha-subunit deduced from its cDNA was 19.5 kDa, the variation might be due to incomplete SDS coating of the 24 kDa form. This was confirmed by the tendency of the 24 kDa variant to polymerize even in the presence of SDS. The molecular mass of the beta-subunit was 17 and 18 kDa in accordance with previous reports. Chemical cross-linking with 1-ethyl-3-(3-dimethylaminopropyl)carbodi-imide resulted in the appearance of a 38 kDa peptide on SDS/PAGE which reacted with both the subunit-specific antisera on Western-blot analysis. On SDS/PAGE at pH 10.2 the active enzyme migrated as an apparent 43 kDa peptide. These results indicate that native human glycosylasparaginase is a heterodimer.
Inclusion of ethyl nitrite in the insufflating gas can obviate the decreased tissue perfusion caused by prolonged carbon dioxide pneumoperitoneum (2004)

Ken-ichiro, Uemura MD; McClaine, Rebecca J. BS; Stamler, Jonathan S. MD; Ahearn, Gregory S. MD; Shimazutsu, Kazufumi MD; Lacassie, Hector J. MD; McClaine, Deborah J. BS; Campbell, Kurt A. BA; Eubanks, Steve W. MD, FACS; Reynolds, James D. PhD Author Information
Estrogen and sex-dependent loss of the vocal learning system in female zebra finches (2021)

Sex hormones alter the organization of the brain during early development and coordinate various behaviors throughout life. In zebra finches, song learning is limited to males, with the associated song learning brain pathways only maturing in males and atrophying in females. While this atrophy can be prevented by treating females with exogenous estrogen during early post-hatch development, the requirement of estrogen during normal male song system development is uncertain. For the first time in songbirds, we administered exemestane, a potent third generation estrogen synthesis inhibitor, from the day of hatching until adulthood in order to reassess the role of estrogen in song circuit development. We examined the behavior, brain anatomy, and transcriptomes of individual song nuclei in these pharmacologically manipulated animals. We found that males with long-term exemestane treatment had diminished male-specific plumage and impaired song learning, but minimal effect on song nuclei sizes and their specialized transcriptome. Consistent with prior findings, females with long-term estrogen treatment retained a functional song system with song nuclei that had specialized gene expression similar, but not identical to males. We also observed that different song nuclei responded to estrogen manipulation differently, with Area X in the striatum being the most altered by estrogen modulation. These findings support the hypothesis that song learning is an ancestral trait in both sexes that was subsequently suppressed in females of some species and that estrogen has come to play a critical role in modulating this suppression as well as refinement of song learning.
Maternal and neonatal hair mercury concentrations—the effect of dental amalgam (2003)

We set out to evaluate the mercury burden in relation to the placement of dental amalgam tooth restorations by using maternal and fetal hair analysis. This was a cross-sectional study involving women who had never had dental amalgam restorations placed, women who had amalgam restorations placed before pregnancy and women who had restorations placed during pregnancy. Fifty-three maternal and fetal hair samples were collected in a standardised manner in the first few days following delivery. When compared with women without restorations there was a significant increase in the maternal hair mercury concentration in women who had dental amalgam placed outside the index pregnancy and also in women who had dental amalgam placed during the index pregnancy. The fetal hair mercury concentration was significantly higher in babies when mothers had been exposed to dental amalgam either before pregnancy or during pregnancy compared with unexposed babies. There was no difference in the maternal or fetal hair mercury levels in the patients who had dental amalgam placed before or during pregnancy.
Efficient formation of heterodimers from peptides and proteins using unsymmetrical polyfluorophenyl esters of dicarboxylic acids (2012)

An efficient method for the heteroconjugation of biomolecules carrying free amino groups was reported previously, where mixed polyfluorophenyl diesters of dicarboxylic acids with varied aliphatic chain length were shown to be efficient reagents for the conjugation of a variety of model biomolecules. The concept was based on the differential reactivity of the esters towards amines. The concept has now been further optimized, and a 2,6-difluorophenyl-pentafluorophenyl diester combination has been demonstrated to be the most efficient, both with respect to selectivity and to reaction rate. A pentafluorophenyl ester reacts faster with an amino group and requires a weaker base than a 2,6-difluorophenyl ester that requires a stronger base and longer reaction time. With the use of this combination of esters, we obtained considerably shortened reaction times compared with those reported previously, yet still retaining the desired selectivity in heteroconjugation. The increased reactivity of the bifunctional reagent allowed the construction of sophisticated peptide heteroconjugates from peptides, carbohydrates and proteins, showing a wide scope of applicability in the field of assembling functional bioconjugates.
Gimap3 and Gimap5 cooperate to maintain T‐cell numbers in the mouse (2013)

Gimap3 (IAN4) and Gimap5 (IAN5) are highly homologous GTP-binding proteins of the Gimap family. Gimap3 and Gimap5, whose transcripts are abundant in mature lymphocytes, can associate with antiapoptotic Bcl-2 family proteins. While it is established that Gimap5 regulates T-cell survival, the in vivo role of Gimap3 is unclear. Here we report the preparation and characteristics of mouse strains lacking Gimap3 and/or Gimap5. We found that the number of T cells was markedly reduced in mice deficient in both Gimap3 and Gimap5. The defects in T-cell cellularity were more severe in mice lacking both Gimap3 and Gimap5 than in mice lacking only Gimap5. No defects in the cellularity of T cells were detected in mice lacking only Gimap3, whereas bone marrow cells from Gimap3-deficient mice showed reduced T-cell production in a competitive hematopoietic environment. Moreover, retroviral overexpression and short hairpin RNAs-mediated silencing of Gimap3 in bone marrow cells elevated and reduced, respectively, the number of T cells produced in irradiated mice. These results suggest that Gimap3 is a regulator of T-cell numbers in the mouse and that multiple Gimap family proteins cooperate to maintain T-cell survival.
Wing-Tip-To-Wing-Tip Aerodynamic Interference (2003)

The aerodynamic interaction of finite wings flying in very close proximity is investigated experimentally. Docked wings are also examined. Tests were carried out in a water tunnel and Particle Image Velocimetry (PIV) was employed to generate velocity data along Trefftz planes. The results indicate that vortex lines “jump”, or reconnect from one wing tip to the next, even in cases of some physical separation. These data can be used to calculate lift and drag and our calculations indicate significant reductions in drag.
Supplementary Figure Legend from miR-212 Increases Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Sensitivity in Non–Small Cell Lung Cancer by Targeting the Antiapoptotic Protein PED (2023)

Supplementary Figure Legend from miR-212 Increases Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Sensitivity in Non–Small Cell Lung Cancer by Targeting the Antiapoptotic Protein PED
Non-trivial link overlap distribution in 3-dimensional Ising spin glasses (2006)

We investigate the distributions of the link overlap, P(Q), in 3-dimensional Ising spin glasses. We use clustering methodology to identify a set of pairs of states from different Gibbs states, and calculate its contribution to P(Q). We find that the distribution over this set does not become trivial as the system size increases.
Playing with 3D printed designs to conceive highly flame retardant multi-materials (2019)

International audience
Early Reconstitution of NK and γδ T Cells and Its Implication for the Design of Post-Transplant Immunotherapy (2018)

Relapse is the most frequent cause of treatment failure after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Natural killer (NK) cells and γδ T cells reconstitute early after allo-HSCT, contribute to tumor immunosurveillance via major histocompatibility complex-independent mechanisms and do not induce graft-versus-host disease. Here we performed a quantitative and qualitative analysis of the NK and γδ T cell repertoire in healthy individuals, recipients of HLA-matched sibling or unrelated donor allo-HSCT (MSD/MUD-HSCT) and umbilical cord blood-HSCT (UCB-HSCT). NK cells are present at high frequencies in all allo-HSCT recipients. Immune reconstitution (IR) of vδ2<sup>+</sup> cells depended on stem cell source. In MSD/MUD-HSCT recipients, vδ2<sup>+</sup> comprise up to 8% of the total lymphocyte pool, whereas vδ2<sup>+</sup> T cells are barely detectable in UCB-HSCT recipients. Vδ1<sup>+</sup> IR was driven by CMV reactivation and was comparable between MSD/MUD-HSCT and UCB-HSCT. Strategies to augment NK cell mediated tumor responses, similar to IL-15 and antibodies, also induced vδ2<sup>+</sup> T cell responses against a variety of different tumor targets. Vδ1<sup>+</sup> γδ T cells were induced less by these same stimuli. We also identified elevated expression of the checkpoint inhibitory molecule TIGIT (T cell Ig and ITIM domain), which is also observed on tumor-infiltrating lymphocytes and epidermal γδ T cells. Collectively, these data show multiple strategies that can result in a synergized NK and γδ T cell antitumor response. In the light of recent developments of low-toxicity allo-HSCT platforms, these interventions may contribute to the prevention of early relapse.
71.2: Distinguished Paper : iMoD™ Display Manufacturing (2006)

Abstract QUALCOMM has developed and transferred to manufacturing iMoD Displays, a MEMS‐based reflective display technology. The iMoD array architecture allows for development at wafer scale, yet easily scales‐up to enable fabrication on flat‐panel display (FPD) lines. In this paper, we will describe the device operation, process flow and fabrication, technology transfer issues, and display performance.
Converter Using SiC‐MOSFET for Ultra‐High‐Speed Elevator (2017)

SUMMARY In this study, we developed a converter based on SiC (Silicon Carbide)‐MOSFET for use in ultra‐high‐speed elevators, with a reduced volume of 15% compared with the conventional converter. We succeeded in reducing the power loss of the converter unit by 56% compared to the conventional converter in one round trip under high temperature condition. Recently, because of their useful characteristics, wide‐gap semiconductors, such as SiC and GaN, have gained considerable attention for use in various applications in the power electronics systems. Therefore, we studied the use of a converter in elevator systems based on SiC‐MOSFET. We used a 1200 V/800 A SiC‐MOSFET module for the converter unit. We developed a prototype of the converter unit and the control panel by applying for the SiC‐MOSFET module for an ultra‐high‐speed elevator. As a result, the setting area of the control panel (main part) becomes less than 43% of the conventional panel. We tried to demonstrate the working of a 68‐kW elevator by applying the prototype control panel. Because of the characteristic of the switching loss of SiC‐MOSFET, the power loss of the converter unit has almost no dependence on temperature. An energy‐saving effect of approximately 17% was achieved in the total elevator system in one round trip under high‐temperature condition.
Quantum and statistical mechanical studies of liquids. 12. Simulation of liquid ethanol including internal rotation (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantum and statistical mechanical studies of liquids. 12. Simulation of liquid ethanol including internal rotationWilliam L. JorgensenCite this: J. Am. Chem. Soc. 1981, 103, 2, 345–350Publication Date (Print):January 1, 1981Publication History Published online1 May 2002Published inissue 1 January 1981https://pubs.acs.org/doi/10.1021/ja00392a018https://doi.org/10.1021/ja00392a018research-articleACS PublicationsRequest reuse permissionsArticle Views347Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts