gebhart/patrepeval huggingface dataset:
Dual roles of E‐cadherin in prostate cancer invasion (2004)

The role(s) of E-cadherin in tumor progression, invasion, and metastasis remains somewhat enigmatic. In order to investigate various aspects of E-cadherin biological activity, particularly in prostate cancer progression, our laboratory cloned unique subpopulations of the heterogeneous DU145 human prostatic carcinoma cell line and characterized their distinct biological functions. The data revealed that the highly invasive, fibroblastic-like subpopulation of DU145 cells (designated DU145-F) expressed less than 0.1-fold of E-cadherin protein when compared to the parental DU145 or the poorly invasive DU145 cells (designated DU145-E). Experimental disruption of E-cadherin function stimulated migration and invasion of DU145-E and other E-cadherin-positive prostate cancer cell lines, but did not affect the fibroblastic-like DU145-F subpopulation. Within the medium of parental DU145 cells, the presence of an 80 kDa E-cadherin fragment was detected. Subsequent functional analyses revealed the stimulatory effect of this fragment on the migratory and invasive capability of E-cadherin-positive cells. These results suggest that E-cadherin plays an important role in regulating the invasive potential of prostate cancer cells through an unique paracrine mechanism.
A mAb recognizing a surface antigen ofMycobacterium tuberculosisenhances host survival (1998)

Murine mAbs reactive with the surface of Mycobacterium tuberculosis were assayed for their ability to affect the course of infection in mice challenged with virulent organisms. An IgG3 mAb (9d8) specific for arabinomannan and reactive with purified antigen from a clinical isolate of M. tuberculosis conferred partial protection on mice after respiratory challenge (30-60% survival >75 days; P </= 0.05). Control mice pretreated with an irrelevant mAb of the same isotype succumbed to tuberculosis within 30 days. Mice with gene disruptions in interferon gamma and major histocompatibility complex Class II also were partially protected from challenge. The protective mAb was neither bactericidal nor inhibitory of infection or bacterial replication. Nevertheless, it profoundly altered the nature of the granulomas in the infected lungs. Mice treated with mAb 9d8 and challenged with M. tuberculosis localized the pathogen within granuloma centers, suggesting that the mAb conferred protection by enhancing a cellular immune response.
Thermal analysis of twin-disc machine for traction tests and scuffing experiments (2018)

Literature agrees that thermal effects have a great influence on friction. However, the heat flows and the thermal behaviour of test rigs used to characterize friction coefficient are largely dependent on their architecture. As a consequence, some discrepancies can be noted between the frictional responses measured by different test benches. Therefore, a thermal model of a twin-disc machine has been developed using the thermal network methodology. This model allows thermal analyses of the traction tests performed with this twin-disc machine. The results reveal that the disc bulk temperature has a significant impact on friction coefficient. Some scuffing experiments are also studied thanks to this numerical model, and a thermal interpretation of classical scuffing criteria is proposed.
Design, Synthesis, and Biological Evaluation of 3,4-Dihydroquinolin-2(1H)-one and 1,2,3,4-Tetrahydroquinoline-Based Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors (2011)

Neuronal nitric oxide synthase (nNOS) inhibitors are effective in preclinical models of many neurological disorders. In this study, two related series of compounds, 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline, containing a 6-substituted thiophene amidine group were synthesized and evaluated as inhibitors of human nitric oxide synthase (NOS). A structure-activity relationship (SAR) study led to the identification of a number of potent and selective nNOS inhibitors. Furthermore, a few representative compounds were shown to possess druglike properties, features that are often difficult to achieve when designing nNOS inhibitors. Compound (S)-35, with excellent potency and selectivity for nNOS, was shown to fully reverse thermal hyperalgesia when given to rats at a dose of 30 mg/kg intraperitonieally (ip) in the L5/L6 spinal nerve ligation model of neuropathic pain (Chung model). In addition, this compound reduced tactile hyperesthesia (allodynia) after oral administration (30 mg/kg) in a rat model of dural inflammation relevant to migraine pain.
Fast Quantum Algorithm for Solving Multivariate Quadratic Equations (2017)

In August 2015 the cryptographic world was shaken by a sudden and surprising announcement by the US National Security Agency NSA concerning plans to transition to post-quantum algorithms. Since this announcement post-quantum cryptography has become a topic of primary interest for several standardization bodies. The transition from the currently deployed public-key algorithms to post-quantum algorithms has been found to be challenging in many aspects. In particular the problem of evaluating the quantum-bit security of such post-quantum cryptosystems remains vastly open. Of course this question is of primarily concern in the process of standardizing the post-quantum cryptosystems. In this paper we consider the quantum security of the problem of solving a system of {\it $m$ Boolean multivariate quadratic equations in $n$ variables} (\MQb); a central problem in post-quantum cryptography. When $n=m$, under a natural algebraic assumption, we present a Las-Vegas quantum algorithm solving \MQb{} that requires the evaluation of, on average, $O(2^{0.462n})$ quantum gates. To our knowledge this is the fastest algorithm for solving \MQb{}.
<title>Superior quality soda-lime float glass for large-area flat panel applications</title> (1994)

Soda—lime glass accounts for over 90% of the glass produced worldwide due to its low melting temperature which facilitates continuous high volume production. Nearly all the flat soda-lime glass is now produced on the float process, eliminating all mechanical surface grinding and polishing operations. This has kept the price of the glass nearly constant over the last twenty-five years. The float process was developed in the late 1950's and was in full utilization by the end of the 1970's. A brief overview of the float process is included, along with key statistics regarding the current capacity, efficiencies, etc. Advances in float technology now result in very parallel high quality surfaces free from major distortions and lenses. However, it is known that this glass is not normally suitable for critical optical applications and we have been exploring +e flatness issue culminating in the introduction of LOF Ultrafloat Glass in 1991. Our efforts to produce a flatter float glass have centered on two critical production areas, as well as the instrumentation/QC procedures needed to insure compliance. The two critical production areas are: 1) hot end lehr roll quality and 2) bath exit/lehr zone temperatures. We have been continually refining these on production runs of the Ultrafloat product, hampered only by the high fixed cost of the float process and the need to service our conventional flat glass customer base with minimal downtime. Details are discussed in this paper. Additional effort was invested in training the plant QC personnel in operation of the interferometer and the interpretation/statistical treatment of the massive amount of interferometric data generated on a continuous glass ribbon 3.3 meters across. Our experience has shown that we can now produce high quality glass with flatness better than 11 fringes across 4" (at the HeNe wavelength), with some areas considerably flatter. These figures apply generally to a 5mm thick glass; thinner glass is appreciably worse as the equilibrium thickness of molten glass on molten tin is about 6.25mm and thin glass undergoes considerable stretching to form the thin ribbon. Future work will include exploring the absolute flatness limit on the float process, the repeatability and process control parameters, as well as the ability to produce larger plates within a given flatness tolerance. Related work will include the effect on parallelism and minimization of internal glass defects.
Local parameter measurement of bubbly flow in vertical pipe by using Wire Mesh Tomography (2004)

The objective of this work is to investigate local void fraction behaviors in countercurrent air-water bubbly flow. Local void fraction of vertical air-water flow in a round tube with inner diameter 50 mm is measured by using Wire Mesh Tomography (WMT). Radial void fraction patterns are visualized and discussed in this work.
Amino acid transporter molecule as a drug target (1999)

Amino acids, especially essential amino acids are required for protein synthesis and as energy sources in all living cells. Since most amino acids are hydrophilic, special membrane proteins are necessary for their transmembrane transport particularly in transformed cells. We cloned a cDNA encoding L-type amino acid transporter, and named it LAT1. LAT1 is highly expressed in most tumor cells and in a few normal tissues such as the bone marrow, spleen, placenta and brain. As a homolog of LAT1, we also cloned LAT2 which is expressed in various normal tissues. In order to clarify the role of LAT1 in tumor cells, we tested a relatively specific inhibitor to LAT1, BCH (2-aminobicyclo-2(2,2,1)-heptane-2-caboxylic acid), and found that BCH inhibited mortality of mice treated with sarcoma cells. In addition, BCH also suppressed strongly T24 carcinoma cell growth. Moreover, LAT1 transports amino acid mimetic drugs. Thus, these results indicate that amino acid transporter molecule such as LAT1 can be a drug target.
Critical Role of Src and SHP-2 in sst2 Somatostatin Receptor-mediated Activation of SHP-1 and Inhibition of Cell Proliferation (2003)

The G protein-coupled sst2 somatostatin receptor acts as a negative cell growth regulator. Sst2 transmits antimitogenic signaling by recruiting and activating the tyrosine phosphatase SHP-1. We now identified Src and SHP-2 as sst2-associated molecules and demonstrated their role in sst2 signaling. Surface plasmon resonance and mutation analyses revealed that SHP-2 directly associated with phosphorylated tyrosine 228 and 312, which are located in sst2 ITIMs (immunoreceptor tyrosine-based inhibitory motifs). This interaction was required for somatostatin-induced SHP-1 recruitment and activation and consequent inhibition of cell proliferation. Src interacted with sst2 and somatostatin promoted a transient Gbetagamma-dependent Src activation concomitant with sst2 tyrosine hyperphosphorylation and SHP-2 activation. These steps were abrogated with catalytically inactive Src. Both catalytically inactive Src and SHP-2 mutants abolished somatostatin-induced SHP-1 activation and cell growth inhibition. Sst2-Src-SHP-2 complex formation was dynamic. Somatostatin further induced sst2 tyrosine dephosphorylation and complex dissociation accompanied by Src and SHP-2 inhibition. These steps were defective in cells expressing a catalytically inactive Src mutant. All these data suggest that Src acts upstream of SHP-2 in sst2 signaling and provide evidence for a functional role for Src and SHP-2 downstream of an inhibitory G protein-coupled receptor.
Select Components and Finish System Design of a Window Air Conditioner with Propane (2017)

This report describes the technical targets for developing a high efficiency window air conditioner (WAC) using propane (R-290). The baseline unit selected for this activity is a GE R-410A WAC. We established collaboration with a Chinese rotary compressor manufacturer, to select an R-290 compressor. We first modelled and calibrated the WAC system model using R-410A. Next, we applied the calibrated system model to design the R-290 WAC, and decided the strategies to reduce the system charge below 260 grams and achieve the capacity and efficiency targets.
Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography (2018)

In adults with treated systemic hypertension, retinal capillary density reduced with higher BP and poorer eGFR. These findings highlight the potential role of OCT-A to study early microvascular changes because of systemic hypertension.
High-Content Imaging to Profile Cellular and Pathogen Responses to Bioactive Probes (2011)

Extended abstract of a paper presented at Microscopy and Microanalysis 2011 in Nashville, Tennessee, USA, August 7–August 11, 2011.
Response to the Letter to the Editor by Eberhard et al. (2017)

In a Letter to the Editor, Eberhard et al. question the validity of our model of skin snip sensitivity and argue against the use of skin snips to evaluate onchocerciasis elimination by mass drug administration. Here we discuss their arguments and compare model predictions with observed data to assess the validity of our model.
Los Angeles I-10 Field Experiment: Incident Patterns (1999)

The Los Angeles I-10 field experiment has produced a large, comprehensive database on incidents and freeway traffic flow characteristics. Field data on incidents were collected through observations of probe vehicle drivers over a 12.5-km (7.8-mi) freeway section. Supplementary information was collected from the California Highway Patrol computeraided dispatch (CHP/CAD) system and freeway service patrol logs. The incident patterns at the study area are described, and the major factors affecting incident frequency and duration are identified. Comparisons of the findings with other databases are discussed. The effects of incidents on traffic flow are also investigated using the empirical data to determine the proportion and characteristics of delay-causing incidents.
Photochromic Solid Materials Based on Poly(decylviologen) Complexed with Alginate and Poly(sodium 4-styrenesulfonate) (2015)

Photochromic solid materials based on the cationic polymer poly(decylviologen) are reported. The solids were obtained by freeze-drying colloidal suspensions of nanocomplexes obtained by mixing aqueous solutions of the polycation with different solutions of polyanions such as poly(sodium 4-styrenesulfonate) or sodium alginate, at a cationic/anionic polymeric charge ratio of 0.7. The photochromic responses of the solid materials fabricated with alginate as complementary charged polyelectrolyte of the cationic polyviologen are faster than those of the solid materials fabricated with poly(sodium 4-styrenesulfonate), achieving coloration kinetics in the order of minutes, and discoloration kinetics in the order of hours for the former. Aromatic-aromatic interactions between the latter polyanion and the polyviologen may stabilize the dicationic form of the viologen derivative, increasing the necessary energy to undergo photoreduction, thus decreasing the reduction kinetics.
An object-oriented design method for knowledge based systems (2002)

It is shown how the object-oriented (OO) paradigm and the KADS methodology's four-layer knowledge paradigm can be used to develop a design method for knowledge-based systems (KBSs). An example is used to illustrate how this method helps the knowledge engineer not only in the design of the system, but also in the implementation of this design into a workable prototype of the system. The method can be implemented in an OO expert system shell that has extended OO programming features. Limitations in the use of state-of-the-art OO languages for knowledge representation are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Detection of Salmonella enteritidis in Feces from Poultry Using Booster Polymerase Chain Reaction and Oligonucleotide Primers Specific for All Members of the Genus Salmonella (1994)

Salmonella enteritidis was identified in feces from hens using the polymerase chain reaction (PCR) and oligonucleotide primers specific for all members of the genus Salmonella. Feces from specific-pathogen-free Leghorn hens were determined to be negative for Salmonella by microbiological culture and by the PCR. Fecal samples were inoculated with known numbers of colony-forming units of S. enteritidis. The DNA was extracted from fecal samples and amplified by the PCR using genus-specific primers. Salmonella were detected in all samples known to be positive; the sensitivity of the assay extended to 1 cfu of S. enteritidis/g feces. Feces that were not inoculated with Salmonella were negative. Microbiological culture was less sensitive than the PCR assay; results of culture of feces with less than 10(2) cfu/g were negative. Although S. enteritidis was used in this study, the oligonucleotide primers used in this study have been previously demonstrated to be genus-specific for Salmonella.
Length‐Dependent Conductance of Molecular Wires and Contact Resistance in Metal–Molecule–Metal Junctions (2008)

Molecular wires are covalently bonded to gold electrodes--to form metal-molecule-metal junctions--by functionalizing each end with a -SH group. The conductance of a wide variety of molecular junctions is studied theoretically by using first-principles density functional theory (DFT) combined with the nonequilibrium Green's function (NEGF) formalism. Based on the chain-length-dependent conductance of the series of molecular wires, the attenuation factor beta is obtained and compared with the experimental data. The beta value is quantitatively correlated to the molecular HOMO-LUMO gap. Coupling between the metallic electrode and the molecular bridge plays an important role in electron transport. A contact resistance of 6.0+/-2.0 Kohms is obtained by extrapolating the molecular-bridge length to zero. This value is of the same magnitude as the quantum resistance.
Assessing the use of 4DCT‐ventilation in pre‐operative surgical lung cancer evaluation (2017)

4DCT-ventilation is an innovative technology developed in radiation oncology that has great potential to translate to the surgical domain. The high correlation results when comparing 4DCT-ventilation to the current standard of care provide a strong rationale for a prospective clinical trial assessing 4DCT-ventilation in the clinical setting. 4DCT-ventilation can reduce the cost and imaging time for patients while providing improved spatial accuracy and quantitative results for surgeons.
Cerium Nanomaterials on Cell Membrane Mechanical Property for Drug Delivery Studies (2014)

The use of nanotechnology in cancer treatment has been raising as one of the most important discoveries in science and technology. With nanomaterial as the new drug delivery system, scientists nowadays are able to find new ways to deal with cancer. Cerium dioxide nanoparticles is a well-known functional rare earth material. Due to its unique properties, it has a wide range of applications in fields spanning: catalysis, electrochemistry, and biology (1). CNPs has been reported having excellent therapeutic potential, specifically abnormalities associated with oxidative stress. However, in order to have better understanding and development of the biomedical applications based on those nanomaterial, the impacts of CNPs on living organism needs to be fully studied. In our research, CNPs with different sizes and shapes were selected. Specifically, nano-rods (~30-200nm), nano-cubes (~20-30nm) and nanoparticles (~3-20nm) fabricated by hydrothermal treatment were being chosen as the model nanoparticles for the studies. The normal skin cancer cells have been used as the living organism. The mechanical property and the adhesion energy of cells’ membranes were analyzed with and without CNPs by using the Atomic Force Microscopy (AFM). From the Force-Distance spectroscopy mode and Hertz's model caculation, we were able to estimate the the elasticity of the cells membranes. Different concentrations (50μM, 125μM, and 250μM) of CNPs were added to the cells and then incubated for different time period (0, 15, 30 and 60 minutes). The results showed that with low concentration (50μM), the cell elasticity maintained around 20kPA. In those cells with 250μM of CNPs added, we noticed that there was a significant change in cell elasticity observed. The result also showed that by increasing incubation time, the cell elasticity has been increasing significantly and at 1hr incubated the changing in cell elasticity is maximum. However, there was no significant change in cell elasticity was observed over 1hr time period for 0.1μM and 50μM of CNPs. This result indicates that the elasticity of cell membranes depends on different nanostructures and nanoceria interaction/internalization to cell and can change significantly at high concentration but makes no effect to the mechanical property of cell at low concentration. (1) A. Karakoti, S. Singh, J. M. Dowding, S. Seal, W. T. Self,, 39 , 4422-4432;(2010)
Synthesis of star block copolymers by controlled ring-opening metathesis polymerization (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of star block copolymers by controlled ring-opening metathesis polymerizationGuillermo C. Bazan and Richard R. SchrockCite this: Macromolecules 1991, 24, 4, 817–823Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://pubs.acs.org/doi/10.1021/ma00004a001https://doi.org/10.1021/ma00004a001research-articleACS PublicationsRequest reuse permissionsArticle Views617Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts