gebhart/patrepeval huggingface dataset:
Engineering the Chemistry and Nanostructure of Porous Silicon Fabry-Pérot Films for Loading and Release of a Steroid (2004)

A method for engineering the surface chemistry and pore dimensions in porous Si films for the purpose of controlling the loading and release of a hydrophobic drug is described. Loading of the steroid dexamethasone is confirmed by Fourier transform infrared spectroscopy, and the release rates are characterized by observation of the appearance of the drug in solution (UV-vis absorption spectroscopy) and by measurement of the Fabry-Perot fringes in the optical reflectivity spectrum of the porous Si film. Optical reflectivity changes provide a measure of the release rate of the drug that is amenable to in-vivo diagnostic applications. Fresh porous Si films are prepared by electrochemical etch and subsequently modified by hydrosilylation with 1-dodecene. The dodecene-modified samples are more robust in aqueous environments and exhibit slower release rates of the drug relative to freshly etched porous Si. Whereas the relatively large dexamethasone molecule is found to infiltrate the freshly etched samples, it does not enter the chemically modified films, because of steric crowding from the dodecyl species. To achieve a high degree of loading into these modified films, the pores are enlarged before hydrosilylation by treatment with an aqueous solution containing HF and dimethyl sulfoxide. The pore expanded, chemically modified samples admit approximately 70% of the dexamethasone that can be admitted into an unmodified (freshly etched) sample. Diffusion of the steroid from the modified, pore expanded films into phosphate-buffered saline solution is slower than from the unmodified sample by a factor of approximately 20, with 90% of the drug delivered in 3 days for the chemically modified films compared to 3 h for the unmodified films.
On the optimal temporal resolution for phase contrast cardiovascular magnetic resonance imaging: establishment of baseline values (2020)

This study presents results from a restrospective analysis of the clinical study NCT01870739 (ClinicalTrials.gov).
Pattern recognition for analysis of cigarette smoke by capillary gas chromatography. Part 1: Total particulate matter (TPM) (1982)

Abstract Complex smoke profiles from fused silica capillary gas chromatography of different cigarette types produce rich information requiring computer and sophisticated statistical analysis to reveal the hidden correlation patterns. In our technique, a Cambridge pad containing total particulate matter (TPM) is extracted with Freon‐11 in a micro‐Soxhlet apparatus. The condenser is maintained at −15°C. After extraction, Freon‐11 is allowed to evaporate under mild conditions. Bis(trimethylsilyl)trifuoroacetamide (BSTFA) is subsequently added to the extract. Trimethylsilylation is completed by maintaining the reaction vessel at 60°C for two hours. A microprocessor‐controlled capillary gas chromatograph with an automatic sampler is used to generate profiles. A link to a host computer provides for transmission of profile reports and access to various statistical and graphic packages. Factor and discriminant analyses are applied to gas chromatographic data from TPM extracts because of their ability in data reduction, pattern extraction and ranking the importance of the gas chromatographic peaks. Some preliminary results from these statistical analyses are discussed.
Les adénomes gonadotropes (1996)

Les adenomes hypophysaires gonadotropes qui sont parmi les plus frequents, ont ete identifies recemment; on estime aujourd'hui qu'environ 80 % des adenomes hypophysaires dits non-secretants sont en fait gonadotropes. Etant donne l'absente de symptomatologie specifique, ils ne sont souvent reconnus que lorsqu'ils sont volumineux, ayant deja entraine un syndrome neurologique, une compression du chiasma optique. Dans la plupart des cas il est possible de les identifier grâce aux produits de secretion ou encore par methodes d'immunohistochimie ou encore par la detection de l'ARN messager correspondant aux sous-unites hormonales. Le traitement reste essentiellement neuro-chirurgical (chirurgie trans-sphenoidale) car, dans la plupart des cas, les agonistes dopaminergiques et les analogues agonistes ou antagonistes de GnRH sont inefficaces.
Stability of Zn/HZSM-5 Catalysts towards Methane Dehydroaromatization Reactions (2019)

Presented by NETL at 251st National Meeting and Exposition, American Chemical Society, 03/16
Clinical scale zinc finger nuclease (ZFN)-driven gene-editing of PD-1 in tumor infiltrating lymphocytes (TIL) for the potential treatment of metastatic melanoma (2014)

Meeting abstracts Multiple inhibitory pathways exist to block the immune response to cancer potentially limiting the effectiveness of adoptive cell transfer (ACT). Programmed cell death-1 (PD-1) is a member of the CD28 superfamily and is expressed on activated T cells. Its ligands, PDL-1 and PDL-2
Reproducibility of in vivo electrophysiological measurements in mice (2022)

Abstract Understanding brain function relies on the collective work of many labs generating reproducible results. However, reproducibility has not been systematically assessed within the context of electrophysiological recordings during cognitive behaviors. To address this, we formed a multi-lab collaboration using a shared, open-source behavioral task and experimental apparatus. Experimenters in ten laboratories repeatedly targeted Neuropixels probes to the same location (spanning secondary visual areas, hippocampus, and thalamus) in mice making decisions; this generated a total of 121 experimental replicates, a unique dataset for evaluating reproducibility of electrophysiology experiments. Despite standardizing both behavioral and electrophysiological procedures, some experimental outcomes were highly variable. A closer analysis uncovered that variability in electrode targeting hindered reproducibility, as did the limited statistical power of some routinely used electrophysiological analyses, such as single-neuron tests of modulation by task parameters. Reproducibility was enhanced by histological and electrophysiological quality-control criteria. Our observations suggest that data from systems neuroscience is vulnerable to a lack of reproducibility, but that across-lab standardization, including metrics we propose, can serve to mitigate this.
Treating Cancer as an Infectious Disease—Viral Antigens as Novel Targets for Treatment and Potential Prevention of Tumors of Viral Etiology (2007)

This strategy is fundamentally different from the prior uses of radioimmunotherapy in oncology, which targeted tumor-associated human antigens and promises increased specificity and minimal toxicity of treatment. It also raises an exciting possibility to prevent virus-associated cancers in chronically infected patients by eliminating cells infected with oncogenic viruses before they transform into cancer.
Organotypic culture of human bone marrow adipose tissue (2010)

The precise role of bone marrow adipose tissue (BMAT) in the marrow remains unknown. The purpose of the present study was therefore to describe a novel method for studying BMAT using 3-D collagen gel culture of BMAT fragments, immunohistochemistry, ELISA and real-time reverse transcription-polymerase chain reaction. Mature adipocytes and CD45+ leukocytes were retained for >3 weeks. Bone marrow stromal cells (BMSC) including a small number of lipid-laden preadipocytes and CD44+/CD105+ mesenchymal stem cell (MSC)-like cells, developed from BMAT. Dexamethasone (10 micromol/L), but not insulin (20 mU/mL), significantly increased the number of preadipocytes. Dexamethasone and insulin also promoted leptin production and gene expression in BMAT. Adiponectin production by BMAT was <0.8 ng/mL under all culture conditions. Dexamethasone promoted adiponectin gene expression, while insulin inhibited it. This finding suggests that dexamethasone, but not insulin, may serve as a powerful adipogenic factor for BMAT, in which adiponectin protein secretion is normally very low, and that BMAT may exhibit a different phenotype from that of the visceral and subcutaneous adipose tissues. BMAT-osteoblast interactions were also examined, and it was found that osteoblasts inhibited the development of BMSC and reduced leptin production, while BMAT inhibited the growth and differentiation of osteoblasts. The present novel method proved to be useful for the study of BMAT biology.
surface wetting changes inlithium niobate single crystals (2005)

Irradiation oflithium niobate crystal surfaces with UVradiation modifies thewetting properties ofthe surface which becomes super-hydrophilic. Thiseffect isusedforspatially selective attachment of chemical species onthelaser exposed areas.
Semantic Metric for Image Library Exploration (2004)

We propose a method for semantic categorization and retrieval of photographic images based on low-level image descriptors derived from perceptual experiments. The method applies multidimensional scaling and hierarchical clustering analysis to identify candidate semantic categories into which human observers organize images. Through a series of subjective experiments we refine our definition of these categories and select a set of low-level image features that uniquely describe them. We then devise a new image similarity metric and develop a prototype system, which identifies the semantic category of the image and retrieves similar images from the database. We tested the metric on a set of new images and compared the categorization results with that of human observers. Our results provide a good match to human performance, thus validating the use of human judgments to develop semantic descriptors. Our method can be used for the enhancement of current retrieval methods, better organization of image/video databases, and the development of more intuitive navigation schemes, browsing methods and user interfaces.
OH Concentration in an Atmospheric-Pressure Methane-Air Flame from Molecular-Beam Mass Spectrometry and Laser-Absorption Spectroscopy (1982)

Abstract The concentration of lhe OH radical in a stoichiometric methane-air flat flame at atmospheric pressure was measured with both laser-absorption spectroscopy and molecular-beam mass spectrometry (MBMS). The nonequilibrium peak OH concentrations and the OH decay rate measured from the two techniques were in good agreement. The OH profile from the MBMS measurements, however, was shifted downstream from the absorption measurements by the MBMS sampling process. A comparison of temperature profiles from thermocouple measurements and from a molecular-beam time-of-flight technique exhibited a similar downstream shift. The MBMS measurements effectively sampled the gas properties approximately five orifice diameters ahead of the sampling-probe tip. Perturbation of the OH concentration profile using various sampling probes indicate the importance of minimizing the length of the sampling-orifice channel to reduce composition relaxation during sampling.
Sophisticated Text Mining System for Extracting and Visualizing Numerical and Named Entity Information from a Large Number of Documents (2008)

We have developed a system that can semiautomat-ically extract numerical and named entity sets from a large number of Japanese documents and can create various kinds of tables and graphs. In our experi-ments, our system semiautomatically created approx-imately 300 kinds of graphs and tables at precisions of 0.2–0.8 with only 2 h of manual preparation from a 2-year stack of newspapers articles. Note that these newspaper articles contained a large quantity of data, and all of them could not be read or checked manually in such a short amount of time. From this perspective, we concluded that our system is useful and convenient for extracting information from a large number of doc-uments. We have constructed a demonstration system. In this paper, we briefly describe the demonstration system.
Effects of Catalysts and pH on Lignin in Partial Wet Oxidation of Wood and Straw Black Liquors (2015)

Partial wet oxidation (PWO) of kraft black liquor (KBL) and wheat straw black liquor (WSBL) was carried out at 170–230 °C. PWO was conducted under oxygen gas only or in the presence of iron catalysts or hydrogen peroxide as an additional oxidant. Unlike the catalysts, increasing temperature enhanced the PWO process in general. Lignin concentration decreased 57–64% and weight-average molar mass of lignin from 2.7–3.3 kDa of original black liquors to 1.5–1.8 kDa after PWO at 210–230 °C. Unlike in KBL, presence of hemicellulose in WSBL was responsible for increasing total acid concentration from 16 g/L to 30 g/L in PWO at 230 °C. A two-stage process comprising lignin precipitation before subsequent PWO decreased chemical oxygen demand of the liquid fraction by 38–41%. Lignin was fractionated into a solid fraction and a water-soluble fraction which showed 21–26% lower polydispersity compared to lignin in the original black liquors.
Impact of Applying a Skin Compression With the Ultrasound Probe on Carotid Artery Strain Elastography (2021)

These results suggest the need of technical guidelines for carotid strain elastography. Using the lowest probe compression while allowing a good B-mode image quality is recommended to improve the robustness of NIVE measurements.
Peering inside the mind: Imaging brain activity with advanced diffuse optical tomography (2016)

An advance in diffuse optical tomography enables three-dimensional imaging of brain activity
High‐Resolution NMR Spectroscopy in Solids by Truly Magic‐Angle Spinning (2005)

Der rechte Winkel: In Festkörper-MAS-NMR-Spektren sind die Signalbreiten von Carbonyl-Kohlenstoffatomen in polykristallinem Cholesterylacetat nicht breiter als 0.039 ppm, wenn der magische Winkel sehr genau eingestellt wird, d. h. auf ±0.004° (siehe Bild). Die bei geringer Abweichung vom Idealwert beobachtete Signalverbreiterung ist vor allem auf Restwechselwirkungen aufgrund der chemischen Verschiebungsanisotropie zurückzuführen. Lange Spinecho-Lebensdauern bis =3.6 s eröffnen den Weg für fortgeschrittene Methoden.
Impact of Miscibility Enhancing Additives on the Flooding Scheme in CO2 EOR Processes (2018)

Abstract Favorable interactions between injection gas and crude oil are crucial for successful carbon dioxide (CO2) recovery processes. The miscibility behavior and thereby the flooding scheme changes with the pressure applied. Although first contact miscibility (FCM) flooding schemes result in most efficient recovery processes, in many cases multiple contact miscibility (MCM) provides economically viable recovery rates already at lower injection pressure. Thus, the determination of the miscibility pressure is a key step in the lab evaluation for CO2 EOR. Miscibility enhancing additives are able to improve the interactions between CO2 and crude oil leading to reduced miscibility pressure. This paper illustrates an easily applicable procedure to identify the pressure required for full miscibility. Using a pressure resistant sapphire cell the phase behavior of mixtures of different crude oils and CO2 with and without additives was investigated at common reservoir conditions. The effect of the additives on the physical phase behavior of CO2/crude oil mixtures and the benefit that can be achieved by their application will be discussed. The miscibility gaps are determined by measuring the phase behavior of CO2/additive/crude oil mixtures as a function of pressure and temperature. The pressure required for full miscibility (physical minimum miscibility pressure (MMPP)), coming along with an FCM scheme, can easily be detected as the pressure above which the miscibility gap closes and a homogeneous mixture is obtained. Another important point, which was determined in this study, was the critical point of the miscibility gap. Its corresponding pressure is the maximum value of the minimum miscibility pressure (MMP) from a thermodynamical viewpoint, above which MCM schemes take place. Hence, knowledge of the critical point of the mixture is an easy to use method to estimate the maximum value of the MMP for a specific reservoir. Adding proper additives to the CO2 improves the miscibility of injection gas and crude oil. By this the miscibility gap shrinks and both the MMP and the MMPP will be reduced significantly compared to the pure CO2/crude oil system. The method presented is a proper, quick, and low-cost alternative to the time-consuming and expensive slim tube experiments commonly used in the oil industry to measure the MMP. Since at pressures above the MMP an MCM procedure is ensured by physics it is the lowest injection pressure that needs to be applied to ensure miscible CO2 EOR. Reducing the MMP and the MMPP using proper additives can lead to a more economical CO2 flood or can even make reservoirs accessible for this technology, which are naturally not.
Erratum (1995)

The Journal of Orthopaedic Research, a publication of the Orthopaedic Research Society (ORS), is the forum for the rapid publication of high quality reports of new information on the full spectrum of orthopaedic research, including life sciences, engineering, translational, and clinical studies.
On performance observability in IoT systems using active measurements (2018)

Network operators are accustomed to use IP-layer active measurements for assessing end-to-end network performance and expect that new technology, such as IoT, provides similar means. This paper investigates the potential and also over-head associated with active measurements in IoT environments, with emphasis on the wireless part. An experimental approach provides insights into RTT accuracy for IoT devices, overhead in terms of energy consumption and network impact, and visualization of network-wide results for bottleneck localization.
A technique for QoS-based system partitioning (2002)

Quality of service (QoS) has been an important topic of many research communities. Combined with an advanced and retargetable compiler, variability of applications-specific very large instruction word (VLIW) processors has been shown to provide an excellent platform for optimizing performance under area constraints. Although media servers and others that are natural candidates for QoS management are embedded systems and implementing QoS management using the applications-specific VLIW platform can provide a new horizon for efficient and effective system design, until now no effort has been reported. In this paper, we introduce a QoS-based system partitioning scheme that addresses the need for maximizing net benefit of a system under resource constraints by exploiting applications-specific VLIW processors. The approach utilizes the modern advances in compiler technology and architectural enhancements that are well matched to the compiler technology. Experimental results indicate that the approach presented in this paper is very effective in system partitioning for QoS given a set of heterogeneous processors.
A phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of OGX-011, a 2'methoxyethyl phosphorothioate antisense to clusterin, in patients with prostate cancer prior to radical prostatectomy (2004)

3033 Background: The clusterin gene encodes a chaperone protein that promotes cell survival. Clusterin is expressed in a variety of cancers including prostate, increases in response to after androgen abaltion and other apoptotic stimuli, and confers a resistant phenotype in pre-clinical models . OGX-011 (Oncogenex Technologies Inc) is a 2nd generation antisense complimentary to clusterin mRNA that inhibits expression of clusterin in xenograft models and thereby increases sensitivity to therapy. The objective of this first-in-man study was to determine phase II dose based on optimal target regulation effect in addition to standard toxicity parameters. Methods: Patients having localized prostate cancer with high-risk features and candidates for prostatectomy were enrolled to this dose escalation trial. OGX-011 was given by IV infusion over 2 hrs at a starting dose of 40mg on days 1, 3, 5, 8, 15, 22, and 29. Buserelin and flutamide were started on day 1. Prostatectomy was performed day 30–36. OGX-011 plasma PK and prostate tissue concentrations were determined. Prostate tissues, serial samples of peripheral blood mononuclear cells, and serum were assessed for clusterinexpression. Results: 20 patients have been enrolled to 6 cohorts with doses of OGX-011 up to 640mg. Toxicity has been limited to grade 1 or 2, including fevers, rigors, fatigue and transient AST and ALT elevations. Plasma PK analysis showed linear increases in AUC with a t1/2 of approximately 2 hrs. OGX-011 prostate tissue concentrations increased with dose to a mean of 2.30 ug/g (∼300nM) at 480mg dosing. Dose dependent decreases in prostate tumor clusterin expression were observed by immunohistochemistry (IHC) and in situ hybridization. By IHC, mean % cancer cells staining for 0 intensity at 480mg was 49.2% (SE 9.0) compared with 3.3–14.5% for lower dose levels. Conclusions: OGX-011 is well tolerated and can inhibit clusterin expression in prostate cancers. Dose escalation and additional PD assessments continue. Supported by a grant from the U.S. Department of Defense and coordinated by the NCIC-CTG. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration OncoGenex Technologies OncoGenex Technologies OncoGenex Technologies Abbott; Aventis OncoGenex Technologies
Effect of the nonaqueous phase on interfacial properties of surfactants. 1. Thermodynamics and interfacial properties of a zwitterionic surfactant in hydrocarbon/water systems (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of the nonaqueous phase on interfacial properties of surfactants. 1. Thermodynamics and interfacial properties of a zwitterionic surfactant in hydrocarbon/water systemsDennis S. Murphy and Milton J. RosenCite this: J. Phys. Chem. 1988, 92, 10, 2870–2873Publication Date (Print):May 1, 1988Publication History Published online1 May 2002Published inissue 1 May 1988https://pubs.acs.org/doi/10.1021/j100321a034https://doi.org/10.1021/j100321a034research-articleACS PublicationsRequest reuse permissionsArticle Views182Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts