gebhart/patrepeval huggingface dataset:
Neutrophil Gelatinase-Associated Lipocalin in the Early Diagnosis of Peritonitis: The Case of Neutrophil Gelatinase-Associated Lipocalin (2012)

Neutrophil gelatinase-associated lipocalin (NGAL), a protein involved in iron handling, has been recognized as a marker of inflammation. In this regard, serum and urine NGAL levels have proven a useful diagnostic tool for acute kidney injury. Bacterial peritonitis is an all too common complication of peritoneal dialysis (PD) and while diagnosis in most cases is routine, there are times when patients present with typical symptoms but do not have an elevated PD effluent white blood cell count. Furthermore, patients may present with an elevated PD fluid white count, a cloudy effluent and no evidence of active infection. In these cases, a discriminating role for peritoneal fluid NGAL would be useful to distinguish bacterial and nonbacterial PD fluid infection. A small case control study was performed which demonstrated a very high sensitivity and specificity for peritoneal fluid NGAL. These preliminary data show that peritoneal fluid NGAL may be a useful tool for the early and accurate diagnosis of peritonitis.
Transport Properties of a MoS2/WSe2 Heterojunction Transistor and Its Potential for Application (2016)

This paper studies band-to-band tunneling in the transverse and lateral directions of van der Waals MoS2/WSe2 heterojunctions. We observe room-temperature negative differential resistance (NDR) in a heterojunction diode comprised of few-layer WSe2 stacked on multilayer MoS2. The presence of NDR is attributed to the lateral band-to-band tunneling at the edge of the MoS2/WSe2 heterojunction. The backward tunneling diode shows an average conductance slope of 75 mV/dec with a high curvature coefficient of 62 V(-1). Associated with the tunnel-diode characteristics, a positive-to-negative transconductance in the MoS2/WSe2 heterojunction transistors is observed. The transition is induced by strong interlayer coupling between the films, which results in charge density and energy-band modulation. The sign change in transconductance is particularly useful for multivalued logic (MVL) circuits, and we therefore propose and demonstrate for the first time an MVL-inverter that shows three levels of logic using one pair of p-type transistors.
Bismuth(III)‐Containing Heteropolytungstates [Bi(XW11O39)2]n– (X = Si, Ge, n = 13; X = P, n = 11) and [Bi(P2W17O61)2]17– (2018)

We report on the synthesis and structural characterization of four bismuth(III)‐containing sandwich‐type heteropolytungstates with Bi in 8‐coordination. The three isostructural Keggin‐type ions [Bi(α‐XW 11 O 39 ) 2 ] n – {X = Si ( 1 ), Ge ( 2 ), n = 13; X = P ( 3 ), n = 11} and the Wells–Dawson‐type ion [Bi(α 2 ‐P 2 W 17 O 61 ) 2 ] 17– ( 4 ) were prepared via simple one‐pot synthetic procedures in aqueous medium. The novel polyanions comprise a Bi 3+ ion linking two monolacunary {XW 11 } or {X 2 W 17 } units in a sandwich‐type fashion. The Bi 3+ ion is coordinated by four oxygens of each monolacunary POM unit, resulting in 8‐coordination with square‐antiprismatic geometry. Such a coordination mode is rare for Bi 3+ .
Tumor growth inhibitory activity of a lymphocyte blastogenesis inhibitory factor. (1990)

A lymphocyte blastogenesis inhibitory factor (LBIF) has been characterized as an immunoregulatory molecule, especially on the T-lymphocyte proliferation. Using fast protein liquid chromatography-purified LBIF, we examined the effect of LBIF on the proliferation of various 18 tumor cell lines in vitro in comparison with those of interferon-alpha, interferon-gamma, tumor necrosis factor-alpha, transforming growth factor-beta 1, or interleukin 1 alpha/beta. We showed here that LBIF strongly inhibited the proliferation of various tumor cell lines irrespective of cell lineage or species. LBIF was effective on a wider spectrum of tumor cell lines than other cytokines tested here. The inhibition resulted from cytotoxic or cytostatic effects, depending on individual characteristics of tumor cell lines. Five cell lines showed insensitivity against LBIF activity, suggesting a plausible involvement of LBIF receptor molecules to transduce LBIF signals. These results suggest that LBIF may play important roles in regulating cell growth.
Implementation of an LDPC decoder for IEEE 802.11n using VivadoTM High-Level Synthesis (2021)

The increasing complexity of hardware designs calls for design methodolgies that use more abstract design entries and increased automation of the implementation process. Highlevel synthesis (HLS) has been a research topic for the past 20 years, and current tools, such as Xilinx VivadoTM HLS promise to bring HLS to widespread use. In this paper we use Xilinx VivadoTMHLS to design an LDPC decoder for 802.11n. Forward error correction decoders are typically implemented in hardware due to the high processing requirements and therefore an LDPC decoder is an appropriate example to demonstrate the power of high-level synthesis
Organic vapor jet deposition using an exhaust (2023)

Methods and systems for organic vapor jet deposition are provided, where an exhaust is disposed between adjacent nozzles. One or more carrier gases may be provided and ejected from a plurality of nozzles. An exhaust may be provided to create a localized vacuum between nozzles. The exhaust may reduce pressure buildup in the nozzles and between the nozzles and the substrate, leading to improved deposition profiles, resolution, and improved nozzle-to-nozzle uniformity. The exhaust may be in fluid communication with an ambient vacuum, or may be directly connected to a vacuum source.
Effect of induced transverse chromatic aberration on peripheral vision (2015)

Transverse chromatic aberration (TCA) is one of the largest optical errors affecting the peripheral image quality in the human eye. However, the effect of chromatic aberrations on our peripheral vision is largely unknown. This study investigates the effect of prism-induced horizontal TCA on vision, in the central as well as in the 20° nasal visual field, for four subjects. Additionally, the magnitude of induced TCA (in minutes of arc) was measured subjectively in the fovea with a Vernier alignment method. During all measurements, the monochromatic optical errors of the eye were compensated for by adaptive optics. The average reduction in foveal grating resolution was about 0.032 ± 0.005 logMAR/arcmin of TCA (mean ± std). For peripheral grating detection, the reduction was 0.057 ± 0.012 logMAR/arcmin. This means that the prismatic effect of highly dispersive spectacles may reduce the ability to detect objects in the peripheral visual field.
Electroluminescence in diamond-like carbon films (1988)

White electroluminescence (EL) was observed for the first time from diamond-like carbon (DLC) films at room temperature. ac voltages in excess of 200 V were applied to a metal-insulator-semiconductor (i.e., DLC)-insulator-metal device structure to observe EL. At an applied voltage of 235 V, the brightness and efficiency were 0.5 fl and 0.002 lm/W, respectively.
Complete Reconstitution and Deorphanization of the 3 MDa NOCAP (NOCardiosis-Associated Polyketide) Synthase (2020)

ABSTRACT Several Nocardia strains associated with nocardiosis, a potentially life-threatening disease, house a nonamodular assembly-line polyketide synthase (PKS) that presumably synthesizes an unknown natural product. Here, we report the discovery and structure elucidation of the NOCAP (NOCardiosis-Associated Polyketide) aglycone by first fully reconstituting the NOCAP synthase in vitro from purified protein components followed by heterologous expression in E. coli and spectroscopic analysis of the purified products. The NOCAP aglycone has an unprecedented structure comprised of a substituted resorcylaldehyde headgroup linked to a 15-carbon tail that harbors two conjugated all- trans trienes separated by a stereogenic hydroxyl group. This report is the first example of reconstituting a trans -acyltransferase assembly-line PKS either in vitro or in E. coli , and of using these approaches to “deorphanize” a complete assembly-line PKS identified via genomic sequencing. With the NOCAP aglycone in hand, the stage is set for understanding how this PKS and associated tailoring enzymes confer an advantage to their native hosts during human Nocardia infections.
Observation of a diffractive contribution to dijet production in proton-proton collisions at √s=7 TeV (2013)

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM
Biophysical and antisense properties of oligodeoxynucleotides containing 7-propynyl-, 7-iodo- and 7-cyano-7-deaza-2-amino-2'-deoxyadenosines (1998)

The synthesis of 7-propynyl-, 7-iodo- and 7-cyano-7-deaza-2-amino-2'-deoxyadenosines is described. The nucleosides were synthesized, functionalized into the phosphoramidites and incorporated into oligodeoxynucleotides. Spectroscopic melting experiments against complementary RNA showed increases of 3-4 degreesC per modification for single substitutions and smaller increases per incorporation for multiple substitutions relative to unmodified control sequences. The 7-propyne and 7-iodo nucleosides were incorporated into antisense sequences targeting the 3'-UTR of murine C- raf mRNA. Both nucleosides demonstrated substitution-dependent potency. The sequences with three and four substitutions of the 7-propyne-7-deaza-2-amino-2'-deoxyadenosine exhibited a 2-3-fold increase in potency over unmodifed controls.
WAHM 2016 (2016)

In recent years there has been a growing interest in augmenting human cognition (attention, engagement, memory, learning, etc.) through ubiquitous technologies. With the ongoing research and development of near-constant capture devices, unlimited storage, and algorithms for retrieval, the resulting personal data has opened the door to a vast range of applications. In the third rendition of this workshop series, we focus on technologies and applications of capturing and integrating personal memory into everyday use cases. With the question What constitutes as a modern lifelog?, we would like to invite researchers, designers, and practitioners to envision and exchange ideas on how ubiquitous technologies and applications enhance people's memory in everyday life. In this one-day workshop, we will formulate application scenarios for making use of ubiquitous technologies in order to push personal data to an application layer where it is used to support and augment the human mind.
Abstract 4198: Highly potent and selective DNA-PK inhibitor M3814 with sustainable anti-tumor activity in combination with radiotherapy (2017)

Abstract Physical or chemical agents that damage DNA such as ionizing radiation are among the most widely used classes of cancer therapeutics today. Double strand breaks (dsb) generated in DNA by radiation induce a multitude of cellular responses, including DNA repair, cell cycle arrest or cell death once the damage is left unrepaired. A complex set of molecular events are responsible for DNA repair mediated by two major repair mechanisms - homologous recombination (HR) or non-homologous end joining (NHEJ). DNA-PKcs together with its regulatory protein subunits Ku70 &amp; Ku80, is an integral component of the NHEJ process and considered an attractive intervention point to inhibit DNA dsb repair. We have developed an orally bioavailable, highly potent &amp; selective inhibitor of DNA-PK, M3814, for cancer therapy in combination with DNA damaging modalities such as radiation &amp; radio-chemotherapy. Here, we present the optimization of initial hit matter &amp; its structure-activity relationships leading to M3814, its chemical structure (first-time disclosure) &amp; preclinical characterization using biochemical, cellular &amp; human tumor xenograft models. M3814 sensitized multiple tumor cell lines to radiation therapy in vitro and strongly enhanced the anti-tumor activity of ionizing radiation in vivo with complete tumor regression by applying a clinically relevant fractionated radiation regimen. These effects are due to inhibition of DNA-PK protein kinase activity as demonstrated by the levels of DNA-PK autophosphorylation in human tumor cell lines &amp; xenograft tumors. M3814 is currently being investigated in PhI/II clinical trials. Citation Format: Thomas Fuchss, Werner W. Mederski, Ulrich Emde, Hans-Peter Buchstallter, Frank Zenke, Astrid Zimmermann, Christian Sirrenberg, Lubo Vassilev, Lars Damstrup, Klaus Urbahns, Andree Blaukat. Highly potent and selective DNA-PK inhibitor M3814 with sustainable anti-tumor activity in combination with radiotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4198. doi:10.1158/1538-7445.AM2017-4198
Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells (2015)

Invariant natural killer T (iNKT) cells comprise a small population of αβ T lymphocytes. They bridge the innate and adaptive immune systems and mediate strong and rapid responses to many diseases, including cancer, infections, allergies, and autoimmunity. However, the study of iNKT cell biology and the therapeutic applications of these cells are greatly limited by their small numbers in vivo (∼0.01-1% in mouse and human blood). Here, we report a new method to generate large numbers of iNKT cells in mice through T-cell receptor (TCR) gene engineering of hematopoietic stem cells (HSCs). We showed that iNKT TCR-engineered HSCs could generate a clonal population of iNKT cells. These HSC-engineered iNKT cells displayed the typical iNKT cell phenotype and functionality. They followed a two-stage developmental path, first in thymus and then in the periphery, resembling that of endogenous iNKT cells. When tested in a mouse melanoma lung metastasis model, the HSC-engineered iNKT cells effectively protected mice from tumor metastasis. This method provides a powerful and high-throughput tool to investigate the in vivo development and functionality of clonal iNKT cells in mice. More importantly, this method takes advantage of the self-renewal and longevity of HSCs to generate a long-term supply of engineered iNKT cells, thus opening up a new avenue for iNKT cell-based immunotherapy.
Effects of interruptions of external beam radiation therapy on outcomes in patients with prostate cancer (2017)

Unintentional treatment breaks during dose escalated external beam radiation therapy for PCa did not cause a significant difference in outcomes, although duration of follow up limits the strength of this conclusion.
A monolithic W-band CPW rat-race mixer with HBT IF amplifier (2002)

This paper reports on a fully monolithic W-band Schottky diode downconverter with an IF amplifier using heterojunction bipolar transistors (HBTs). We use a coplanar waveguide (CPW) as a transmission line element for a rat-race, because a CPW requires one-side wafer processing only. The conversion gain is +9.5 dB with the HBT amplifier and -8.8 dB without the HBT amplifier at an RF of 95 GHz. The isolation from the LO port to the RF port is 29 dB with the HBT amplifier and 27 dB without the HBT amplifier.
Two-component initiator systems for the ring-opening polymerization of oligomeric cyclic bisphenol-A carbonates: Thein situ cleavage of disulfides by triarlyphosphines (1997)

A two-component initiator system based on the in situ cleavage of phenyl disulfide by a triarylphosphine has been developed for the ring-opening polymerization of cyclic bisphenol-A (BPA) carbonate oligomers. This development has potential use in composite applications such that the prepolymer can suitably wet the composite material before being converted to high-molecular-weight polymer. The initiator precursors (phenyl disulfide and triphenylphosphine) do not independently initiate significant ring-opening polymerization of the oligomeric cyclic BPA carbonate mixture. A mixture of cyclic BPA carbonate oligomers and one of the initiator components (phenyl disulfide), combined and heated at 300°C with a mixture of the cyclics and the other initiator component (triphenylphosphine), does produce a high-molecular-weight polymer (Mw = ∼ 70,000). The polymerization-initiating species is thought to be thiophenyltriphenylphosphonium thiophenoxide. The effects of concentration of the initiator components, reaction temperature, time, and so forth on polymerization were studied; in general, the degree of polymerization ranged from about 65 to 75%. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 66: 2251–2255, 1997
<title>Multiaxial constitutive behavior of ferroelectric materials</title> (2000)

Multiaxial ferroelectric/ferroelastic constitutive laws governing the behavior of ceramic lead zirconate titanate (PZT) are needed for numerical calculations of stress and electric field in the vicinity of field concentrators such as cracks, inhomogeneities, and partial electrodes. Such constitutive laws are under development and are in need of experimental verification. Multiaxial constitutive behavior has been measured using tubular specimens, both poled and unpoled. The results were used to map out a yield surface. The composition used, 8/65/35 PLZT, was found to obey a Tresca yield criterion when in the unpoled state. The yield surface was found to be a function of the polarization state. Kinematic and isotropic hardening appear to be good candidates for describing subsequent yield surfaces. The multiaxial measurements are also being used to verify and calibrate a multiaxial micromechanics based constitutive model. This constitutive model has been implemented in a finite element code written by the authors. Some of the capabilities of this code are presented and discussed. This proceedings article gives an overview of our recent research in this area.
Cyclidene complexes with bulky substituents (1995)

Abstract Unbridged Ni(II) cyclidene complexes have been prepared with bulky substituents at the terminal nitrogen atoms (R2 = -C(Me)2CH2N(Me)2; -CH(Ph)2; -CH2C(Me)3; -CH2CH(Ph)2) (substituent R3 at the adjoining carbon = Me). Complexes containing the last two substituents and bridged with m-xylylene and (CH2)6 have also been synthesised. The effects of the bulky substituents on 13C n.m.r spectra, electrochemical behaviour and oxygen binding ability are examined. The crystal structures of the m-xylylene-bridged complexes with R2 = CH2C(Me)3, R3 = Me (I) and R2 = Me, R3 = Ph (II) have been determined; both are monoclinic, P21\c, with (I) a = 13.463(1); b = 14.506(2); c = 26.72492)A, β = 91.45(1), R = 0.082 for 3895 observed (I/σ(I)> = 2.0) reflections; (II) a = 24.721(6), b = 10.934(3), c = 16.321(5)Å, β = 97.30(2)°, R = 0.074 for 2992 observed (I/σ(I)> = 3.0) reflections
Combinatorial parallel synthesis and automated screening of a novel class of liquid crystalline materials (2002)

Combinatorial parallel synthesis has led to the rapid generation of a single-compound library of novel fluorinated quaterphenyls. Subsequent automated screening revealed liquid crystalline (LC) behaviour and gave qualitative relationships of molecular structures and solid state properties.
Scattering Loss in Thin, Shallow-Ridge Silion-on-Insulator Waveguides (2012)

Roughness induced scattering in thin, shallow-ridge silicon on insulator waveguides is analyzed by coupled mode theory and verified experimentally. Roughness in different waveguide regions causes different scattering natures of TM and TE modes.
Ion-Depleting Action of Perm-Selective Membranes for Enhancing Electrical Communication and Gated Ion Channel Activity in Cell Cultures (2021)

Ion-depletion action of an ion-selective membrane produces a moat channel that electrically insulates a cell colony and elevates the cell medium potential uniformly to synchronously activate and deactivate the voltage-gated ion channels of all cells. The result is robust synchronization with strong intercellular electrical communication and the discovery of ion channel deactivation that is only possible when the cells are in communication. The study suggests that the collective response of a cell colony to external stimuli is distinct from that of a single cell. Cell proliferation must hence be guided with strong intercellular communication and proper exogenous stimuli.
Experimental Production of Respiratory Tract Infection with Mycoplasma pneumoniae in Rhesus Monkeys (1976)

Knowledge of the pathogenesis of pneumonia due to Mycoplasma pneumoniae has been derived primarily from experimental infection of rodents. As part of an effort to establish a model with a closer resemblance to man, three seronegative, young, adult rhesus monkeys (Macaca mulatta) were inoculated with M. pneumoniae (10(7.4) cfu per animal) by oropharyngeal administration of coarse-particle aerosol. Five to six days after exposure of the animals, cultures obtained from the upper respiratory tract were positive for M. pneumoniae. Each animal subsequently developed a serologic response, as determined by complement fixation, complement-mediated killing, and tetrazolium-reduction inhibition techniques. Infection was subclinical, and serial chest roentgenograms failed to disclose pneumonia throughout the course of infection. Blood cell counts and titers of cold agglutinins remained unchanged. Althought M. pneumoniae was recovered from the upper respiratory tract of two monkeys for 50 days, there was no evidence of transmission of infection to cage-mate controls inoculated with broth.
Experimental realization of chiral Landau levels in two-dimensional Dirac cone systems with inhomogeneous effective mass (2023)

Chiral zeroth Landau levels are topologically protected bulk states. In particle physics and condensed matter physics, the chiral zeroth Landau level plays a significant role in breaking chiral symmetry and gives rise to the chiral anomaly. Previous experimental works on such chiral Landau levels are mainly based on three-dimensional Weyl degeneracies coupled with axial magnetic fields. Their realizations using two-dimensional Dirac point systems, being more promising for future applications, were never experimentally realized before. Here we propose an experimental scheme for realizing chiral Landau levels in a two-dimensional photonic system. By introducing an inhomogeneous effective mass through breaking local parity-inversion symmetries, a synthetic in-plane magnetic field is generated and coupled with the Dirac quasi-particles. Consequently, the zeroth-order chiral Landau levels can be induced, and the one-way propagation characteristics are experimentally observed. In addition, the robust transport of the chiral zeroth mode against defects in the system is also experimentally tested. Our system provides a new pathway for the realization of chiral Landau levels in two-dimensional Dirac cone systems, and may potentially be applied in device designs utilizing the chiral response and transport robustness.
Vendor-Interoperable Elastic Optical Interfaces: Standards, Experiments, and Challenges [Invited] (2015)

This paper aims to review the status of standardization activities on the black link (BL) and corresponding alien wavelength concepts. It discusses experimental work on filterless optical networks conducted within a dedicated Deutsche Telekom project. The general prospects and existing challenges concerning elastic extensions of the BL are also assessed. Furthermore, we present relevant work on control and management plane interoperability comprising generalized multi-protocol label switching and transport software defined networking aspects. In the second part of the article, we report on the latest dual-vendor experiments on data plane interoperability in terms of digital signal processing technology for next generation 1.28&#xA0;Tb/s PM-16QAM super-channels. Finally, we present a network reachability analysis based on the widely used Gaussian noise model in the context of data plane interoperability. This analysis estimates the network-wide impact of the single-vendor versus the dual-vendor approach.