gebhart/patrepeval huggingface dataset:
Content Based Image Retrieval Using Deep Learning Convolutional Neural Network (2021)

Abstract Content-based image retrieval (CBIR) is a widely used method for image retrieval from large and unlabeled image collections. However, users are not satisfied with the traditional methods of retrieving information. Moreover the abundance of online networks for production and distribution, as well as the quantity of images accessible to consumers, continues to expand. Therefore, in many areas, permanent as well as widespread digital image processing takes place. Therefore, the rapid access to these large image databases as well as the extraction of identical images from this large set of images from a given image (Query) pose significant challenges as well as involves efficient techniques. A CBIR system’s efficiency depends fundamentally on the calculation of feature representation as well as similarity. For this purpose, they present a basic but powerful deep learning system focused on Convolutional Neural Networks (CNN) and composed of feature extraction and classification for fast image retrieval. We get some promising findings from many detailed observational studies for a number of CBIR tasks using image database, which reveals some valuable lessons for improving the efficiency of CBIR. CBIR systems allow another image dataset to locate related images to such a query image. The search per picture function of Google search has to be the most popular CBIR method.
A perfect palindrome in the Escherichia coli chromosome forms DNA hairpins on both leading- and lagging-strands (2014)

DNA palindromes are hotspots for DNA double strand breaks, inverted duplications and intra-chromosomal translocations in a wide spectrum of organisms from bacteria to humans. These reactions are mediated by DNA secondary structures such as hairpins and cruciforms. In order to further investigate the pathways of formation and cleavage of these structures, we have compared the processing of a 460 base pair (bp) perfect palindrome in the Escherichia coli chromosome with the same construct interrupted by a 20 bp spacer to form a 480 bp interrupted palindrome. We show here that the perfect palindrome can form hairpin DNA structures on the templates of the leading- and lagging-strands in a replication-dependent reaction. In the presence of the hairpin endonuclease SbcCD, both copies of the replicated chromosome containing the perfect palindrome are cleaved, resulting in the formation of an unrepairable DNA double-strand break and cell death. This contrasts with the interrupted palindrome, which forms a hairpin on the lagging-strand template that is processed to form breaks, which can be repaired by homologous recombination.
The Width:thickness Ratio of the Patella (2008)

Establishing the appropriate size of the patellar implant-bone composite is one of the important steps ensuring functional success in arthroplasty. Conventionally, the patella is measured intraoperatively and its thickness is used to guide the depth of resection. However, in a diseased joint, this may not reflect the native patellar thickness. We studied the relationship between the patellar thickness and various patellar dimensions on three-dimensional reconstructed computed tomographic scans from 37 normal adult knees. Patellar width correlated with thickness. The average patellar width:thickness ratio was 2.0 (standard deviation, 0.106; 95% confidence interval, 1.96-2.03). The cartilage thickness was on average 2.5 mm (standard deviation, 1.0). The width:thickness ratio was similar in 79 digital radiographs taken before TKA of knees without patellofemoral disease (mean, 2.1; standard deviation, 0.28). When compared with the two other methods for calculating patellar resection described in the literature, the width:thickness ratio was more reliable. The width:thickness ratio appears anatomically constant and may be a useful guide for estimating premorbid patellar thickness.
Figure S2 from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery (2023)

&lt;p&gt;Sub-tumouricidal PDP does not increase systemic toxicity of chemotherapy. Changes in mouse body weight were monitored longitudinally before and after treatment.&lt;/p&gt;
Expanding the Semiconductor Nanowire Design Space (2012)

Michael Filler presented a lecture at the Nano@Tech Meeting on August 28, 2012 at 12 noon in room 1116 of the Marcus Nanotechnology Building.
Effects of vlsE Complementation on the Infectivity of Borrelia burgdorferi Lacking the Linear Plasmid lp28-1 (2004)

The loss of linear plasmid lp28-1, which contains the vls antigenic variation locus, is associated with reduced infectivity of Borrelia burgdorferi in immunocompetent mice. The recombinant shuttle vector pBBE22, which includes the virulence determinant BBE22 from lp25 and restores infectivity to readily transformable B. burgdorferi lacking lp25 and lp56, was used to determine the effect of trans expression of vlsE on virulence. Spirochetes lacking lp28-1 were complemented with the plasmid pBBE22:vlsE, containing both BBE22 and vlsE. VlsE protein produced by this construct was expressed and surface accessible in in vitro-cultured B. burgdorferi, as determined by surface proteolysis and immunoblot analysis. Clones lacking lp25 but containing lp28-1 and either pBBE22 or pBBE22:vlsE were reisolated consistently from immunocompetent mice 8 weeks after infection. In contrast, a clone lacking both lp25 and lp28-1 and complemented with pBBE22:vlsE was isolated from only a single tissue of one of six C3H/HeN mice 8 weeks postinfection. These results indicate that either an intact vls antigenic variation locus or another determinant on lp28-1 is required to restore complete infectivity. In addition, an isogenic clone that retained lp28-1 was complemented with the vlsE shuttle plasmid and was examined for vlsE sequence variation and infectivity. Sequence variation was not observed for the shuttle plasmid, indicating that the cis arrangement of vlsE and the vls silent cassettes in lp28-1 facilitate vlsE gene conversion. Lack of vlsE sequence variation on the shuttle plasmid thus did not result in clearance of the trans-complemented strain in immunocompetent mice under the conditions tested.
Multiple epitaxial lateral overgrowth of GaN thin films using a patterned graphene mask by metal organic chemical vapor deposition (2020)

Single-crystal gallium nitride (GaN) thin films were grown using a graphene mask via multiple epitaxial lateral overgrowth (multiple-ELOG). During the growth process, the graphene mask self-decomposed to enable the emergence of a GaN film with a thickness of several hundred nanometres. This is in contrast to selective area growth of GaN using an SiO 2 mask leading to the well known hexagonal-pyramid shape under the same growth conditions. The multiple-ELOG GaN had a single-crystalline wurtzite structure corresponding to the crystallinity of the GaN template, which was confirmed with electron backscatter diffraction measurements. An X-ray diffraction rocking curve of the asymmetric 102 reflection showed that the FWHM for the multiple-ELOG GaN decreased to 405 from 540′′ for the underlying GaN template. From these results, the self-decomposition of the graphene mask during ELOG was experimentally proven to be affected by the GaN decomposition rather than the high-temperature/H 2 growth conditions.
Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography (2019)

Neurokinin 1 receptor (NK1R) has key regulating functions in the central and peripheral nervous systems, and NK1R antagonists such as aprepitant have been approved for treating chemotherapy-induced nausea and vomiting. However, the lack of data on NK1R structure and biochemistry has limited further drug development targeting this receptor. Here, we combine NMR spectroscopy and X-ray crystallography to provide dynamic and static characterisation of the binding mode of aprepitant in complexes with human NK1R variants. <sup>19</sup>F-NMR showed a slow off-rate in the binding site, where aprepitant occupies multiple substates that exchange with frequencies in the millisecond range. The environment of the bound ligand is affected by the amino acid in position 2.50, which plays a key role in ligand binding and receptor signaling in class A GPCRs. Crystal structures now reveal how receptor signaling relates to the conformation of the conserved NP<sup>7.50</sup>xxY motif in transmembrane helix VII.
Revealing the Surface Effect at Atomic Scale in Silver Hollandite (2018)

Hollandite based manganese oxides recently attracted much attention because of their large tunnel size to facilitate topological ionic intercalation Hollandite is widely recognized as an intrinsic 1D diffusion material, in which ions diffuse along the [001] tunneled direction. Interestingly, besides the 1D ionic diffusion, operando lithiation experiments also demonstrate ionic transport within the a-b plane However, the underlying mechanisms remain elusive. In this study, we reveal the surface effect and discuss its role on ionic diffusion.
Query Focused Variable Centroid Vectors for Passage Re-ranking in Semantic Search. (2018)

In this paper, we propose a new approach for passage re-ranking. We show that variable (i.e. non-static) centroid vectors for passages, created based on the given query, significantly improves passage re-ranking results compared to that obtained using static centroid vectors. We also show that the results are comparable to RWMD-Q, an existing (non-centroid based unsupervised) state of the art. The experiments reported are conducted on two different datasets in both neural and co-occurrence based distributional semantics settings.
Long‐Range Electron Transfer through a Single‐walled Carbon Nanotube Sheet (2008)

A flow reactor system is designed for the reduction of cytochrome c mediated by a sheet of single-walled carbon nanotubes, as schematically illustrated in the figure. The reaction kinetics of the reduction of cytochrome c by an added reductant solution is monitored by optical absorption spectroscopy to elucidate the mechanism of long-range electron transfer in this novel bio-inspired reactor.
Toward Reconstructing Surfaces With Arbitrary Isotropic Reflectance : A Stratified Photometric Stereo Approach (2007)

We consider the problem of reconstructing the shape of a surface with an arbitrary, spatially varying isotropic bidirectional reflectance distribution function (BRDF), and introduce a novel, stratified photometric stereo method. By using a particular configuration of lights, it is possible to use symmetry in the image measurements resulting from BRDF isotropy to estimate at each point a plane containing the surface normal. For differentiable surfaces, this allows us to recover the isocontours of the depth map, but not the actual depth associated with each contour. The isocontour structure provides topological information about the surface (critical points, Reeb graph, etc.). By using additional cues in the image data or imposing additional constraints on the surface (e.g., shadows, specular highlights, Helmholtz reciprocity, uniform BRDF), the unknown height of each isocontour can be estimated and the metric structure is resolved. We validate this technique on real and synthetic data by successfully recovering the isocontours of the depth map from images.
Cloning and vaccination properties of sporozoite antigen Eimeria stiedae (1995)

* INRA, centre de Tours, Station de Pathologie aviaire et parasitologie 37380 Nouzilly (FRA) Diffusion du document : INRA, centre de Tours, Station de Pathologie aviaire et parasitologie 37380 Nouzilly (FRA)
Accuracy of Scalar PDF Method for Turbulent Nonpremixed Combustion (Evaluation of Reynolds Stress Model) (2011)

The accuracy of a scalar probability density function method, which is able to deal with reaction exactly, has been investigated in terms of a second order closure model for flow field evaluation. Numerical calculations have been conducted in the configuration of a hydrogen/nitrogen jet nonpremixed flame. The second order closure model is based on a Reynolds stress model. The present solution is a combined PDF/moment method, in which PDFs are evolved to match both the means and variances of mixture fraction from both the PDF and moment methods. Then the two moment equations of mixture fraction are based on the second order closure. The present evaluation is based on a comparative study with the first order closure model based on a k-ε 2 equation model. The present scalar PDF model with the second order closure model evaluates adequately anisotropy and then the anisotropy affects strongly the mixing process in the near field. The spread of the jet flame is able to be evaluated adequately by the second order closure model than by the first order one. The early flow filed is extremely important and the present initial low turbulences affect the downstream flame structure.
Stainless Steels for High Temperature Heat Exchangers (2006)

Abstract Stainless steels have been used for high temperature applications since their invention due to their inherent ability to form a protective chromium-rich oxide. As technology has continued to evolve, alloy compositions and processing schemes have been tailored to meet the demands of new applications, acting in synergy to affect the high temperature properties of the alloy. This paper reviews recent work at ATI Allegheny Ludlum on the development of alloys and processing to improve the high temperature properties of stainless steels. A joint project with Oak Ridge National Lab (ORNL) to improve the creep resistance of Type 347 stainless steel is discussed. In addition, the development of a creep and oxidation-resistant 20Cr-25Ni austenitic stainless steel will be reviewed. This alloy, developed in coil form in conjunction with Solar Turbines, has good high temperature strength and phase stability, while maintaining excellent oxidation resistance. The primary goal of this work has been in developing durable stainless steel foils for turbine recuperator applications. The work has since expanded to include other applications and product forms.
The second-generation eCLIPs Endovascular Clip System: initial experience (2017)

OBJECTIVE Treatment of wide-necked intracranial aneurysms is associated with higher recanalization and complication rates; however, the most commonly used methods are not specifically designed to work in bifurcation lesions. To address these issues, the authors describe the evolution in the design and use of the eCLIPs (Endovascular Clip System) device, a novel hybrid stent-like assist device with flow diverter properties that was first described in 2008. METHODS A registry was established covering 13 international centers at which patients were treated with the second-generation eCLIPs device. Aneurysm morphology and rupture status, device neck coverage, coil retention, and procedural and late morbidity and mortality were recorded. For those patients who had undergone successful implantation more than 6 months earlier, the final imaging and clinical follow-up results and need for re-treatment were recorded. RESULTS Thirty-three patients were treated between June 2013 and September 2015. Twenty-five (76%) patients had successful placement of an eCLIPs device; 23 (92%) of these 25 patients had complete data. Eight cases of nondeployment occurred during the 1st year of use, consistent with a learning curve; no failures of deployment occurred thereafter. Two periprocedural transient ischemic attacks and 2 asymptomatic thrombotic events occurred. Twenty-one (91%) of 23 patients underwent follow-up at an average of 8 months (range 3-18 months); 9 (42.9%) of these 21 patients demonstrated an improvement in Raymond grade at follow-up; no cases of worsening Raymond grade were recorded, and 17 (81.0%) patients sustained a modified Raymond-Roy Classification class of I or II angiographic result at follow-up. Two delayed ruptures were recorded, both in previously coiled, symptomatic giant aneurysms where the device was used as a part of a salvage strategy. CONCLUSIONS The second-generation eCLIPs device is a viable treatment option for bifurcation aneurysms. The aneurysm occlusion rates in this initial clinical series are comparable to the initial experience with other bifurcation support devices.
Cyclooxygenase-2 Regulates Th17 Cell Differentiation during Allergic Lung Inflammation (2011)

COX-2 is a critical regulator of Th17 cell differentiation during allergic lung inflammation via autocrine signaling of PGI(2) and PGF(2α) through their respective cell surface receptors.
Investigation of perception-oriented coding techniques for video compression based on large block structures (2011)

Recent investigations have shown that one of the most beneficial elements for higher compression performance in highresolution video is the incorporation of larger block structures. In this work, we will address the question of how to incorporate perceptual aspects into new video coding schemes based on large block structures. This is rooted in the fact that especially high frequency regions such as textures yield high coding costs when using classical prediction modes as well as encoder control based on the mean squared error. To overcome this problem, we will investigate the incorporation of novel intra predictors based on image completion methods. Furthermore, the integration of a perceptualbased encoder control using the well-known structural similarity index will be analyzed. A major aspect of this article is the evaluation of the coding results in a quantitative (i.e. statistical analysis of changes in mode decisions) as well as qualitative (i.e. coding efficiency) manner.
Serially concatenated space-time code using 2D interleaver (2002)

A new space-time code employing a serially concatenated code structure is proposed. The proposed structure has L independent layers, and the serially concatenated turbo encoding is performed in each layer. The key structure, a 2-dimensional (time and space) interleaver, is placed between the inner encoder and the outer encoder, and reorders the encoded bits in time and layer according to its interleaving pattern. By using the 2D interleaver, temporal and spatial diversity gains are sufficiently achieved. Moreover, it reduces the correlations between the inputs and the outputs of the interleaver, protecting against error propagation from the inner decoder to the outer decoder. By adding the proposed scheme, the bit error performance is remarkably improved, with only negligible complexity increase.
Probes labelled with energy transfer coupled dyes (2023)

Compositions are provided comprising sets of fluorescent labels carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donors at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having different donor-acceptor pairs can be modified to have substantially the same mobility under separation conditions, by varying the distance between the donor and acceptor in a given pair. Particularly, the fluorescent compositions find use as labels in sequencing nucleic acids.
Mid and Late Outcomes Support Use of Contemporary Continuous Flow Left Ventricular Assist Devices in the Elderly. (2014)

PURPOSE: End stage heart failure in the elderly is one of few growing cohorts in cardiac surgery. We reviewed a large group of elderly patients’ mid and long term results with contemporary continuous flow left ventricular assist devices (CF LVAD). METHODS: We performed a retrospective review of a single center identifying all patients with approved HeartMate II CF LVADs (2003-2012). Patients were divided into < 65 versus > 65 years. Descriptive statistics and multivariate regression was done. RESULTS: Demographic, perioperative characteristics and outcomes of 300 patients are shown in Table 1. Mean follow-up in both groups was 2 years (max 8 yrs). Patients > 65 were more likely ischemic etiology and required redo sternotomy. They were less likely to have their LVAD explanted and spent less time in ICU. There was no significant difference in mortality (Figure 1) or other clinical outcomes (Table 1). Age > 65 was not a risk factor for mortality (HR 1.2, 95% CI 0.6-2.6, p=0.5) however redo surgery was (HR 1.7, 95% CI 1.1-2.9, p=0.04). Sensitivity analyses at age thresholds found significant divergence in survival curves at 70 years, however age did not emerge as an independent predictor of mortality and the cohort sample was not sufficient for meaningful conclusions. CONCLUSIONS: This is a large cohort of contemporary patients with CF LVADs with the longest follow-up in the literature. CF LVADs are an effective safe option in elderly; age is less likely an issue versus poor protoplasm or complex operations such as redo cardiac operations.Table: No Caption available.Figure: No Caption available.
Glutamate receptor phosphorylation and trafficking in pain plasticity in spinal cord dorsal horn (2010)

Glutamate is the major excitatory neurotransmitter in the central nervous system. Considerable evidence suggests that both ionotropic and metabotropic glutamate receptors are involved in pain hypersensitivity. However, glutamate receptor-based therapies are limited by side-effects because the activities of glutamate receptors are essential for many important physiological functions. Here, we review recent key findings in molecular and cellular mechanisms of glutamate receptor regulation and their roles in triggering and sustaining pain hypersensitivity. Targeting these molecular mechanisms could form the basis for new therapeutic strategies for the treatment of chronic pain.
Sapphyrins induce apoptosis in hematopoietic tumor–derived cell lines and show in vivo antitumor activity (2005)

Sapphyrins are pentapyrrolic, metal-free, expanded porphyrins. In the present study, the activity of sapphyrins as anticancer agents in hematopoietic-derived tumor cells was explored. It was found that a dihydroxylated water-soluble sapphyrin derivative (PCI-2000) is a potent inducer of apoptosis in a wide variety of tumor cell lines including lymphoma (Ramos, DHL-4, and HF-1), leukemia (Jurkat and HL-60), and myeloma (8226/S, 1-310, C2E3, and 1-414). PCI-2000 triggers an apoptotic pathway in these tumor cells as shown by release of cytochrome c from mitochondria; activation of caspases 9, 8, and 3; cleavage of the caspase substrate poly(ADP-ribose) polymerase; and Annexin V binding. Apoptosis can be partially inhibited by overexpression of the antiapoptotic protein Bcl-2 or treatment with benzyloxycarbonyl-valine-alanine-aspartic acid-fluoromethylketone, a cell-permeable caspase inhibitor. Both PCI-2000 and PCI-2010, a tetrahydroxy bis-carbamate derivative of PCI-2000, result in increased levels of phosphorylated p38 mitogen-activated protein kinase. Inhibition of p38 mitogen-activated protein kinase phosphorylation resulted in a synergistic increase of PCI-2000 cytotoxicity. PCI-2010 showed less toxicity in mice than PCI-2000 and was active in slowing the growth of Ramos and HL-60 tumor xenografts in nude mice. These results provide preclinical rationale for the further study of sapphyrins for potential use in the treatment of hematopoietic-derived tumors.