gebhart/patrepeval huggingface dataset:
Effect of Polymer Matrices on Oxygen-Binding of a Cobalt Porphyrin Complex (1987)

Abstract Oxygen-binding of the (1-methylimidazole)-[α,α′,α″, α'″-5,l0,15,20-tetrakis(o-pivalamidophenyl)porphinato]cobalt(II) complex fixed in polymer membranes, poly-(dimethylsiloxane), poly(butyl methacrylate), and poly(methylmethacrylate), was studied spectroscopically. The apparent oxygen-binding affinity increased with oxygen solubility in the polymer matrix, which was corrected with the solubility coefficient of oxygen in the polymer.
Figure S5 from The PET-Tracer <sup>89</sup>Zr-Df-IAB22M2C Enables Monitoring of Intratumoral CD8 T-cell Infiltrates in Tumor-Bearing Humanized Mice after T-cell Bispecific Antibody Treatment (2023)

&lt;p&gt;Figure S5 shows PET scans of each experimental animal of the FOLR1-TCB study.&lt;/p&gt;
Tris(quinolin-8-olato)indium(III) (2003)

The single-crystal structure of the title compound, [In(C9H6NO)3], is described. Quinolinolates of the elements of the group IIIB (denoted by MQ3), Al, Ga, and In, have been of continuous interest to organometallic and physical chemists, in particular, for the last 50 years. Organic light-emitting diodes (OLEDs) utilizing GaQ3 and InQ3, the gallium and indium analogs, respectively, of the most widely used OLED material AlQ3, were first explored in the early 1980s and continue to be the subject of current research. To the best of our knowledge, the structure reported here is the first-ever facial MQ3-type structure, confirmed by single-crystal X-ray crystallography.
1209-P: Profound Metabolic Benefits Observed in an Eight-Week GK Rat Study of a Novel Orally Administered Polymeric Duodenal Exclusion Therapy: Implications for Type 2 Diabetes (T2D) Therapy (2021)

Background: Roux-en-Y gastric bypass surgery produces significant weight loss and improvement in T2D and insulin resistance, attributed predominantly to duodenal exclusion. To mimic this effect non-invasively, we developed an oral, gut-restricted, inert polymer (GLY-POL) that interacts with mucus in the proximal small intestine to form a dynamic barrier excluding the duodenal lining from luminal contents. We therefore hypothesized that such treatment would result in significant improvement in glycemia and weight loss in a rodent model of type 2 diabetes. Methods: Goto-kakizaki (GK) rats were gavaged daily for 8 weeks. The treatment group (n = 7) received 1.5 ml of GLY-POL (8 wt %) solution and control group (n=7) received saline. Five metabolic responses were evaluated weekly: body weight, food intake, oral glucose (oGTT) and mixed meal tolerance (mMTT) tests, and HOMA-IR. Results: oGTT performed after chronic GLY-POL therapy produced a profound reduction of post-prandial glycemia (PPG) (incremental area under curve (iAUC)  = 60 – 70%, p&amp;lt;0.0005) compared to control; the PPG reduction amplified with duration of therapy through the study period. Similar robust reduction in PPG iAUC was evident during mMTT (iAUC  &amp;gt; 55%, p &amp;lt; 0.005). Fasting plasma glucose was lower in GLY-POL group (p&amp;lt;0.05) with improvement in HOMA-IR (p&amp;lt;0.005). GLY-POL therapy resulted in 6% weight loss compared to control (p&amp;lt;0.005), without a difference in food intake between the groups. Conclusion: Our results confirm a key role for chronic duodenal exclusion in improving the systemic metabolic milieu. Chronic once daily oral GLY-POL therapy results in a profound reduction in FPG, PPG, insulin resistance and weight loss. GLY-POL therapy offers the potential for a novel non-invasive approach for glycemic and weight control in T2D patients that mimics the effects of gastric bypass without the adverse effects associated with this surgery. Disclosure A. Nimgaonkar: Employee; Self; Glyscend Inc. S. Kulkarni: None. J. S. Petersen: Employee; Self; Glyscend Inc. S. Polomoscanik: Employee; Self; Glyscend Inc. P. J. Pasricha: Stock/Shareholder; Self; Glyscend. K. Colbert: Employee; Self; Glyscend Inc., LifeSprout, Inc. T. H. Jozefiak: Employee; Self; Glyscend Inc., Stock/Shareholder; Self; GLYCOLOGIX LLC. J. Vora: Advisory Panel; Self; Bayer Inc., Other Relationship; Self; AstraZeneca. M. Vieira: Employee; Self; AstraZeneca. T. Carlson: None. L. Liu: None. Funding National Science Foundation (1521347)
Evaluation of Topology Optimization Using 3D Printing for Bioresorbable Fusion Cages (2022)

A topology-optimized PCL cage with BMP-2 is capable of resulting in an intervertebral fusion, similar to a conventional ring-based design of the same bioresorbable material.
Dexhand: A Space qualified multi-fingered robotic hand (2011)

Despite the progress since the first attempts of mankind to explore space, it appears that sending man in space remains challenging. While robotic systems are not yet ready to replace human presence, they provide an excellent support for astronauts during maintenance and hazardous tasks. This paper presents the development of a space qualified multi-fingered robotic hand and highlights the most interesting challenges. The design concept, the mechanical structure, the electronics architecture and the control system are presented throughout this overview paper.
Poly(caprolactone-co-trimethylenecarbonate) urethane acrylate resins for digital light processing of bioresorbable tissue engineering implants (2019)

To exploit the usability of Digital Light Processing (DLP) in regenerative medicine, biodegradable, mechanically customizable and well-defined polyester urethane acrylate resins were synthesized based on poly(caprolactone-co-trimethlenecarbonate). By controlling the monomer ratio, the resultant fabricated constructs showed tunable mechanical properties, degradation and attached hMSC morphologies.
ChemInform Abstract: Probing Protein Stability with Unnatural Amino Acids. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Exploring Weak Ligand–Protein Interactions by Long‐Lived NMR States: Improved Contrast in Fragment‐Based Drug Screening (2014)

Ligands that have an affinity for protein targets can be screened very effectively by exploiting favorable properties of long-lived states (LLS) in NMR spectroscopy. In this work, we describe the use of LLS for competitive binding experiments to measure accurate dissociation constants of fragments that bind weakly to the ATP binding site of the N-terminal ATPase domain of heat shock protein 90 (Hsp90), a therapeutic target for cancer treatment. The LLS approach allows one to characterize ligands with an exceptionally wide range of affinities, since it can be used for ligand concentrations [L] that are several orders of magnitude smaller than the dissociation constants K(D). This property makes the LLS method particularly attractive for the initial steps of fragment-based drug screening, where small molecular fragments that bind weakly to a target protein must be identified, which is a difficult task for many other biophysical methods.
Abstract 4619: Protein palmitoylation in non-small cell lung cancer (NSCLC): DHHC5 palmitoyltransferase as a potential therapeutic target (2014)

Abstract Post-translational palmitoylation of intracellular proteins is mediated by protein palmitoyltransferases (PAT) belonging to the DHHC family, which share a common catalytic Asp-His-His-Cys (DHHC) motif. According to a genome-wide siRNA screen scoring for growth suppression in over 50 non-small cell lung cancer (NSCLC) cell lines, DHHC family members are strikingly over-represented. Among the tested DHHC palmitoyltransferases, knockdown of DHHC5 showed cell growth inhibition in many cell lines in the initial screen. To further investigate the growth suppression in response to DHHC5 depletion, transient and stable knockdowns of DHHC5 were undertaken in a dozen of NSCLC cell lines identified in the genome-wide screen using siRNAs and lentiviral shRNAs. Such knockdown was also performed in three immortalized human lung bronchial epithelial cell lines (HBECs). The gene expression and protein levels of DHHC5 were analyzed by RT-PCR and immunoblotting, both of which showed efficient knockdown levels. Cell proliferation and anchorage-dependent/independent colony formation assays indicated that DHHC5 knockdown led to cell growth arrest and decreased cell clonogenicity in most of the tested NSCLC cell lines in vitro, but not in the HBECs. H1299, H358 and H2009 cell lines were particularly dependent on DHHC5 expression and the growth-suppression phenotype of DHHC5 stable knockdown H1299/H358/H2009 cells was rescued by overexpression of DHHC5. The catalytically inactive DHHC5 mutant was not able to provide rescue. In vivo tumor formation assays were then carried out by injecting H1299 and H358 control cells and DHHC5 stable knockdown cells subcutaneously into NOD/SCID mice. DHHC5 knockdown led to absence or dramatically decreased tumor xenograft formation. Furthermore, a Tet-On inducible system with TRIPZ shRNA lentiviral delivery was established in H1299. Mouse xenografts using this H1299 Tet-on inducible cell line showed similar results. As DHHC5 function is needed for optimal lung cancer cell growth, it will be important to identify physiologically relevant substrates in order to develop inhibitors of DHHC5 function. Future plans include microarray and protein kinase array analysis to distinguish possible signaling pathways in which DHHC5 may be involved, as well as palmitoyl-protein profiling of normal and knockdown DHHC5 cell lines by mass spectrometry. Citation Format: Hui Tian, Jui-Yun Lu, Chunli Shao, Kenneth Huffman, Ryan Carstens, John D. Minna, Sandra L. Hofmann. Protein palmitoylation in non-small cell lung cancer (NSCLC): DHHC5 palmitoyltransferase as a potential therapeutic target. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4619. doi:10.1158/1538-7445.AM2014-4619
Human lung cancer cell lines exhibit resistance to retinoic acid treatment. (1993)

Retinoic acid (RA) and nuclear retinoic acid receptors (RARs) have been implicated in a variety of human malignancies including lung cancer, and RA has been proposed as a chemopreventive agent for bronchogenic carcinoma. Normal human tracheobronchial epithelial cells show dramatic induction of RAR-beta mRNA and significant growth inhibition after RA treatment. In contrast, 17 of 22 small cell lung cancer (SCLC) and 9 of 15 non-SCLC lines treated with 1 microM RA showed no significant growth inhibition. Of interest, 5 SCLC lines with high levels of myc gene family expression related to c-, N-, or L-myc gene amplification exhibited growth inhibition (28-87%), whereas 2 non-SCLC lines actually showed growth stimulation after treatment with 1 microM RA. The lines varied greatly in their constitutive expression of RAR-beta mRNA, and 15 of 20 SCLC and 8 of 15 non-SCLC lines failed to show RAR-beta mRNA induction after RA treatment. Six cell lines showed possible alterations in the coding region of RAR-beta by complementary DNA (cDNA)/polymerase chain reaction (PCR) analysis using primers common to the RAR-beta1,2,3 isoforms, since other regions would undergo cDNA/PCR amplification whereas the DNA binding domain would not. Nonetheless, no abnormal band shift patterns in cDNA amplified by PCR were found by single strand conformation polymorphism analysis covering all 1344 base pairs of the RAR-beta open reading frame. Finally, no abnormalities in RAR-alpha gene structure or expression were identified by Southern and Northern blot analysis, including lines with cytogenetic abnormalities of 17q21. We conclude that abnormalities of the RAR-beta system are common in human lung cancer cell lines.
Analysis and design of parallel mechanisms with flexure joints (2004)

Flexure joints are frequently used in precision motion stages and micro-robotic mechanisms due to their monolithic construction. The joint compliance, however, can affect the static and dynamic performance of the overall mechanism. In this paper, we consider the analysis and design of general platform type parallel mechanisms containing flexure joints. We consider static performance measures such as task space stiffness and manipulability, while subject to constraints such as joint stress, mechanism size, workspace volume, and dynamic characteristics. Based on these performance measures and constraints, we adopt the multi-objective optimization approach. We first obtain the Pareto frontier, which can then be used to select the desired design parameters based on secondary criteria such as performance sensitivity. To simplify presentation, we consider only lumped approximation of flexure joints in the pseudo-rigid-body approach. A planar mechanism is included to illustrate the analysis and design techniques. Tools presented in this paper can also be applied to a broader class of compliant mechanisms, including robots with inherent joint flexibility as well as compliant robots for contact tasks.
[Effect of curcumin on the injury in hippocampal neurons and the expression of RANTES in hippocamp during cerebral ischemia/ reperfusion in spontaneously hypertensive rats SHR]. (2014)

SHR are more susceptible to ischemia/reperfusion induced hippocampal neuronal injury which may be improved by curcu min. Its underlying mechanism is possibly associated with the inhibition of RANTES protein expression level.
Oxidative S-dealkylation of tert-butyl aryl sulphides: a novel route to 3-substituted-3H-1,2-benzodithioles (1991)

Substituted 3H-1,2-benzodithioles are readily synthesized by an oxidative S-dealkylation reaction of mercapto tert-butyl sulphides 8 with N-bromosuccinimide in acetonitrile without prior deprotection of the tert-butyl group.
B-Cell Depletion Attenuates White and Gray Matter Pathology in Marmoset Experimental Autoimmune Encephalomyelitis (2011)

This study investigated the effect of CD20-positive B-cell depletion on central nervous system (CNS) white and gray matter pathology in experimental autoimmune encephalomyelitis in common marmosets, a relevant preclinical model of multiple sclerosis. Experimental autoimmune encephalomyelitis was induced in 14 marmosets by immunization with recombinant human myelin oligodendrocyte glycoprotein in complete Freund adjuvant. At 21 days after immunization, B-cell depletion was achieved by weekly intravenous injections of HuMab 7D8, a human-anti-human CD20 antibody that cross-reacts with marmoset CD20. In vivo magnetic resonance imaging showed widespread brain white matter demyelination in control marmosets that was absent in CD20 antibody-treated marmosets. High-contrast postmortem magnetic resonance imaging showed white matter lesions in 4of the 7 antibody-treated marmosets, but these were significantly smaller than those in controls. The same technique revealed gray matter lesions in 5 control marmosets, but none in antibody-treated marmosets. Histologic analysis confirmed that inflammation, demyelination, and axonal damage were substantially reduced in brain, spinal cord, and optic nerves of CD20 antibody-treated marmosets. In conclusion, CD20-postive B-cell depletion by HuMab 7D8 profoundly reduced the development of both white and gray matter lesions in the marmoset CNS. These data underline the central role of B cells in CNS inflammatory-demyelinating disease.
Draft genome sequence of Streptomyces hyaluromycini MB-PO13T, a hyaluromycin producer (2018)

<i>Streptomyces hyaluromycini</i> MB-PO13<sup>T</sup> (=NBRC 110483<sup>T</sup> = DSM 100105<sup>T</sup>) is type strain of the species, which produces a hyaluronidase inhibitor, hyaluromycin. Here, we report the draft genome sequence of this strain together with features of the organism and generation, annotation and analysis of the genome sequence. The 11.5 Mb genome of <i>Streptomyces hyaluromycini</i> MB-PO13<sup>T</sup> encoded 10,098 putative ORFs, of which 5317 were assigned with COG categories. The genome harbored at least six type I PKS clusters, three type II PKS gene clusters, two type III PKS gene clusters, six NRPS gene clusters, and one hybrid PKS/NRPS gene cluster. The type II PKS gene cluster including 2-amino-3-hydroxycyclopent-2-enone synthetic genes was identified to be responsible for hyaluromycin synthesis. We propose the biosynthetic pathway based on bioinformatic analysis.
Ligand field parameters and photochemistry from charge-transfer excited states of bis[o-phenylenebis(dimethylarsine)] iron(III) halides (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLigand field parameters and photochemistry from charge-transfer excited states of bis[o-phenylenebis(dimethylarsine)] iron(III) halidesJeffrey I. Zink, Po-Hsin Liu, and Betsy AnfieldCite this: Inorg. Chem. 1979, 18, 4, 1013–1017Publication Date (Print):April 1, 1979Publication History Published online1 May 2002Published inissue 1 April 1979https://pubs.acs.org/doi/10.1021/ic50194a027https://doi.org/10.1021/ic50194a027research-articleACS PublicationsRequest reuse permissionsArticle Views41Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
When and How to Change Quorums on Wide Area Networks (2009)

In wide-area settings, unpredictable events, such as flash crowds caused by nearly instantaneous popularity of services, can cause servers that are expected to respond quickly to instead suddenly respond slowly. This presents a problem for achieving consistently good performance in quorum-based distributed systems, in which clients must choose which quorums (sets of servers) to access. Typically,clients are motivated to choose quorums containing the servers that respond fastest. Often, these may be the closest servers, but when the closest servers are particularly slow to respond, e.g., because of a changed workload, servers that are farther may actually respond faster. In this paper, we show how clients can locally change their quorum selections efficiently such that the overall system performance rapidly converges to that of the best global strategy for the current conditions. Moreover, we discuss how to benefit even when changes in quorums must be accompanied by expensive state-transfer operations.
ChemInform Abstract: Asymmetric Induction in an Enammonium‐Iminium Rearrangement. Mechanistic Insight via NMR, Deuterium Labeling, and Reaction Rate Studies. Application to the Stereoselective Synthesis of Pyrroloisoquinoline Antidepressants. (1990)

Abstract Reductive deoxygenation of both the trans and cis alcohols (Ia) or (Ib) leads to product mixtures highly biased in favor of the trans diastereomer (III).
Irregular Polar Turbo Product Coding for High-Throughput Optical Interface (2018)

We propose polar turbo product code (TPC) to enable parallel/pipeline decoding, for high-throughput transmission. With irregular polar codes, the computational complexity and latency can be significantly reduced, yet outperforming BCH-constituent TPC by 0.5 dB.
Synthesis and Characterization of Nanometer-Size Fe3O4 and γ-Fe2O3 Particles (1998)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionSynthesis and Characterization of Nanometer-Size Fe3O4 and γ-Fe2O3 ParticlesYoung Soo Kang, Subhash Risbud, John F. Rabolt, and Pieter StroeveCite this: Chem. Mater. 1998, 10, 6, 1733Publication Date (Web):May 28, 1998Publication History Published online28 May 1998Published inissue 1 June 1998https://pubs.acs.org/doi/10.1021/cm970904shttps://doi.org/10.1021/cm970904scorrectionACS PublicationsCopyright © 1998 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1653Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (30 KB) Get e-Alertsclose Get e-Alerts
The unusual self-organising behaviour of a glycosteroidal bolaphile (2009)

In this communication we report on the self-organising properties of a novel asymmetric bolaphile composed of sugar and steroidal units. The material was found to exhibit unusual phase changes in that it formed a cubic phase upon heating, whereas upon cooling it formed a lamellar phase. This change in property was ascribed to kinetic versus thermodynamic behaviour at the phase transition to the liquid.
IMMOBILIZATION AND APPLICATIONS OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE: A REVIEW (2013)

Immobilized enzymes have been used extensively in the fields of food industry, materials processing, textiles, detergents, biochemical and chemical industries, biotechnology, and pharmaceuticals. Studies on immobilization of glucose-6-phosphate dehydrogenase have been less extensive than those for other industrially applicable enzymes. Immobilization of glucose-6-phosphate dehydrogenase has been carried out for the formation of biosensors for the estimation of glucose, ATP, phosphate, and so on. The present review deals with the attempts made for immobilization of glucose-6-phosphate dehydrogenase and its applications for various purposes.