gebhart/patrepeval huggingface dataset:
Crystal growth and scintillation properties of lithium potassium yttrium complex fluoride (2010)

KLi(Y <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> Ce <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> )F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> (x = 0.001, 0.01, 0.03) single crystals were grown from the melt using the precise atmosphere control type Micro-Pulling-Down (μ-PD) method to examine their potential as a new thermal neutron scintillators. The grown crystals were single-phase materials as confirmed by XRD. Ce <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> 5d-4f luminescence observed around 340 nm when exited by α-ray. The radio luminiscence measurements under α-ray excitation ( <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">241</sup> Am) demonstrated the light yield of 450 [ph/5.5MeV-α] and the decay time excited by α-ray exhibited 47 and 256 ns.
Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy (2013)

Inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed inhibition of PPAT isozymes from several species, with the most potent inhibition of enzymes from Gram-positive species. Mode-of-inhibition studies with Streptococcus pneumoniae and Staphylococcus aureus PPAT demonstrated representatives of this series to be reversible inhibitors competitive with phosphopantetheine and uncompetitive with ATP, binding to the enzyme-ATP complex. The potency of this series was optimized using structure-based design, and inhibition of cell growth of Gram-positive species was achieved. Mode-of-action studies, using generation of resistant mutants with targeted sequencing as well as constructs that overexpress PPAT, demonstrated that growth suppression was due to inhibition of PPAT. An effect on bacterial burden was demonstrated in mouse lung and thigh infection models, but further optimization of dosing requirements and compound properties is needed before these compounds can be considered for progress into clinical development. These studies validated PPAT as a novel target for antibacterial therapy.
Role of Academic Drug Discovery in the Quest for New CNS Therapeutics (2017)

There was a greater than 50% decline in central nervous system (CNS) drug discovery and development programs by major pharmaceutical companies from 2009 to 2014. This decline was paralleled by a rise in the number of university led drug discovery centers, many in the CNS area, and a growth in the number of public-private drug discovery partnerships. Diverse operating models have emerged as the academic drug discovery centers adapt to this changing ecosystem.
Genomic and gene expression profiling of minute alterations of chromosome arm 1p in small-cell lung carcinoma cells (2005)

Genetic alterations occurring on human chromosome arm 1p are common in many types of cancer including lung, breast, neuroblastoma, pheochromocytoma, and colorectal. The identification of tumour suppressors and oncogenes on this arm has been limited by the low resolution of current technologies for fine mapping. In order to identify genetic alterations on 1p in small-cell lung carcinoma, we developed a new resource for fine mapping segmental DNA copy number alterations. We have constructed an array of 642 ordered and fingerprint-verified bacterial artificial chromosome clones spanning the 120 megabase (Mb) 1p arm from 1p11.2 to p36.33. The 1p arm of 15 small-cell lung cancer cell lines was analysed at sub-Mb resolution using this arm-specific array. Among the genetic alterations identified, two regions of recurrent amplification emerged. They were detected in at least 45% of the samples: a 580 kb region at 1p34.2-p34.3 and a 270 kb region at 1p11.2. We further defined the potential importance of these genomic amplifications by analysing the RNA expression of the genes in these regions with Affymetrix oligonucleotide arrays and semiquantitative reverse transcriptase-polymerase chain reaction. Our data revealed overexpression of the genes HEYL, HPCAL4, BMP8, IPT, and RLF, coinciding with genomic amplification.
The virtual device: expanding wireless communication services through service discovery and session mobility (2006)

We present a location-based, ubiquitous service architecture, based on the session initiation protocol (SIP) and a service discovery protocol that enables users to enhance the multimedia communications services available on their mobile devices by discovering other local devices, and including them in their active sessions, creating a "virtual device." We have implemented our concept based on Columbia University's multimedia environment and we show its feasibility by a performance analysis.
Design and testing of RFID sensor tag fabricated using inkjet-printing and electrodeposition (2014)

The passive RFID tag with an added sensing function is of interest to many applications. In particular, applications where RFID tagging is already considered to be the next step, such as food items, are a specific target. This paper demonstrates a flexible RFID tag sensor fabricated using a low cost technique with an added zero-cost sensing function. It is more specifically applied to the sensing of degradable food, in particular beef meat in our demonstrated example. To reach this, the antenna is designed in such a way to be sensitive to the variation of the dielectric permittivity of the meat over time. The design of the sensing tag as well as its fabrication process are described. The fabrication involves inkjet printing of a silver nanoparticle based ink on a commercial low cost PET film to create a seed layer. It is followed by a copper electrodeposition step on top of the silver pattern to complete the tag to obtain the desired thickness and conductivity of the tag antenna. The results of the electrical tests showed that with the inkjet printing–electrodeposition combination it is possible to produce flexible electrically conductive patterns for practical RFID applications. The tag was then tested in close-to-real-world conditions and it is demonstrated that it can provide a sensing function to detect the consumption limit of the packaged beef.
Envelope Spectral Kurtosis and SVD Analysis of Stray Flux Signals for the Diagnosis of Field Winding Faults in Synchronous Motors (2021)

In this work, the application of an unsupervised algorithm based on Singular Values Decomposition (SVD) and on the Envelope Spectral Kurtosis of stray flux signals is proposed as a way to detect field winding faults in synchronous motors. These signals are analyzed both under starting and under steady-state regimes for two different types of flux sensors. Furthermore, a new fault indicator based on the SVD of the envelope of the spectral kurtosis is proposed, yielding satisfactory results for fault classification, observing a common trend in both cases at starting and in steady-state independent of the flux sensor type and position. A comparative analysis between the two motor operating regimes is carried out, obtaining several conclusions about the suitability of each regime for the application of the methodology in real applications.
Cost Comparison of Networks Using Traditional 10 and 40 Gb/s Transponders Versus OFDM Transponders (2008)

OFDM allows flexible adjustment of transmission data rate according to channel properties. We propose to use OFDM transponders and calculate the cost at which OFDM networks result in lower CAPEX compared to traditional networks.
The effects of a type 4 phosphodiesterase inhibitor and the muscarinic cholinergic antagonist tolterodine tartrate on detrusor overactivity in female rats with bladder outlet obstruction (2007)

Both IC485 and tolterodine tartrate reduced detrusor overactivity in rats with BOO. In addition, doses of IC485 that suppressed non-voiding contractions had no effect on voiding function. Therefore, selective PDE4 inhibitors deserve further study as potential agents for treating detrusor overactivity in patients with BOO.
Parylene N as a dielectric material for through silicon vias (2008)

This paper reports on the feasibility of parylene N as a dielectric material for through silicon vias (TSV). TSV are the key enabling technology for 3D wafer laver packaging. Parylene is used as an insulating material in one of the approaches adopted for realizing 3D wafer level packaging at IMEC. This paper discusses main issues regarding the processing of parylene N for the TSV application. First, the thickness uniformity of as-deposited parylene across the wafer and inside the via is investigated. The results show that for 200 mm wafers, within-wafer and wafer-to-wafer thickness is sufficiently uniform. The 1-sigma thickness variation of less than 4 percent for both cases is measured. 1 sigma thickness variation of less than 5 percent is observed from batch to batch. Second, the effect of substrate, temporary glue layer and carrier wafer for thinned device wafers on the dry etching of parylene is analyzed. The experiments show that the etching was sufficiently uniform across the wafer; and the uniformity across the surface is recorded to be greater than 95 percent. There is no considerable effect of substrate or bonding layer thickness, however carrier wafer influence the etching rate.
Stochastic Simulated Quantum Annealing for Fast Solution of Combinatorial Optimization Problems (2023)

In this paper, we introduce stochastic simulated quantum annealing (SSQA) for large-scale combinatorial optimization problems. SSQA is designed based on stochastic computing and quantum Monte Carlo, which can simulate quantum annealing (QA) by using multiple replicas of spins (probabilistic bits) in classical computing. The use of stochastic computing leads to an efficient parallel spin-state update algorithm, enabling quick search for a solution around the global minimum energy. Therefore, SSQA realizes quantum-like annealing for large-scale problems and can handle fully connected models in combinatorial optimization, unlike QA. The proposed method is evaluated in MATLAB on graph isomorphism problems, which are typical combinatorial optimization problems. The proposed method achieves a convergence speed an order of magnitude faster than a conventional stochastic simulaated annealing method. Additionally, it can handle a 100-times larger problem size compared to QA and a 25-times larger problem size compared to a traditional SA method, respectively, for similar convergence probabilities.
Session details: Session 4b: scientia potentia est (2014)

No abstract available.
Electrical Impedance Tomography by Elastic Deformation (2008)

This paper presents a new algorithm for conductivity imaging. Our idea is to extract more information about the conductivity distribution from data that have been enriched by coupling impedance electrical measurements to localized elastic perturbations. Using asymptotics of the fields in the presence of small volume inclusions, we relate the pointwise values of the energy density to the measured data through a nonlinear PDE. Our algorithm is based on this PDE and takes full advantage of the enriched data. We give numerical examples that illustrate the performance and the accuracy of our approach.
Analysis for Procainamide and N-Acetyl Procainamide in Plasma or Serum by High-Performance Liquid Chromatography (1977)

A high-performance liquid chromatography method is presented for simultaneous analysis for procainamide and N-acetyl procainamide in plasma or serum. The procedure involves internal-standard addition, organic extraction, and separation on a reverse-phase column. The detection limit for procainamide is 0.1 mg/liter and the calibration plot is linear to at least 30 mg/liter. Comparison with a colorimetric assay for procainamide gave a correlation coefficient of 0.989. We checked for interference by a large series of appropriate drugs, and found none, nor did icteric or lipemic sera present problems.
Feedback-based Coding Algorithms for Braodcast Erasure Channels with Degraded Message Sets (2012)

We consider single-hop broadcast packet erasure channels (BPEC) with degraded message sets and instantaneous feedback regularly available from all receivers, and demonstrate that the main principles of the virtual-queue-based algorithms in [1], which were proposed for multiple unicast sessions, can still be applied to this setting and lead to capacity-achieving algorithms. Specifically, we propose a generic class of algorithms and intuitively describe its rationale and properties that result in its efficiency. We then apply this class of algorithms to three examples of BPEC channels (with different numbers of users and 2 or 3 degraded message sets) and show that the achievable throughput region matches a known capacity outer bound, assuming feedback availability through a separate public channel. If the feedback channel is not public, all users can still decode their messages, albeit at some overhead which results in an achievable throughput that differs from the outer bound by O(N/L), where L is the packet length. These algorithms do not require any prior knowledge of channel statistics for their operation.
T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans (1995)

We investigated the immune response to proteolipid protein (PLP), the most abundant central nervous system myelin protein in humans. A total of 8207 short-term T cell lines were generated from 49 individuals, 39 patients with multiple sclerosis and 10 control subjects. As we have reported previously, the frequency of PLP-reactive T cells did not differ between the two groups. To determine immunodominant PLP epitopes, proliferative responses of 971 PLP-specific lines were tested with 27 overlapping 20-amino acid peptides encompassing the human PLP sequence and the binding affinities of the PLP peptides to DRB5*0101 and DRB1*1501, DR2 MHC class II isotypes associated with multiple sclerosis, were determined. The T cell response after primary PLP stimulation was focused on two immunodominant epitopes comprising residues p30-49 and p180-199. These two fragments were recognized after processing of native protein by APCs and were situated in hydrophilic regions of PLP exhibiting only moderate affinity to DR2 molecules. In contrast, when T cells from DR2+ subjects were stimulated initially by individual synthetic peptides with either high or low affinity to DRB5*0101 and DRB1*1501 isotypes, additional cryptic epitopes were recognized. MHC restriction of lines specific for the cryptic PLP epitopes were related to binding affinity to DR2 isotypes. Our results indicate that protein Ags are recognized in vivo as immunodominant epitopes after Ag processing by APCs and as cryptic epitopes after processing, presumably by extracellular proteolytic enzymes.
Novel Ignition Property Measurements for Various Fuels using a Micro Flow Reactor with a Controlled Temperature Profile (2015)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;This paper presents new methodology of ignition property measurements using a micro flow reactor with a controlled temperature profile, which is a spin-off methodology developed through microcombustion studies during the last decade. Stable multi-stage reaction zones were observed in low flow velocity regime for hydrocarbons and it was found that unsteady multi-stage oxidations of hydrocarbons were examined by stable multi-stage reaction zones termed as weak flames. This methodology has been further applied to various fuels. Effects of research octane number of primary reference fuels on weak flames were examined and it was shown that stabilized temperature levels and appearances of weak flames have apparent correlations with RON. Recent works using the micro flow reactor were also introduced.&lt;/div&gt;&lt;/div&gt;
Crash Protection of Stock Car Racing Drivers - Application of Biomechanical Analysis of Indy Car Crash Research (2006)

Biomechanical analysis of Indy car crashes using on-board impact recorders (Melvin et al. 1998, Melvin et al. 2001) indicates that Indy car driver protection in high-energy crashes can be achieved in frontal, side, and rear crashes with severities in the range of 100 to 135 G peak deceleration and velocity changes in the range of 50 to 70 mph. These crashes were predominantly single-car impacts with the rigid concrete walls of oval tracks. This impressive level of protection was found to be due to the unique combination of a very supportive and tight-fitting cockpit-seating package, a six-point belt restraint system, and effective head padding with an extremely strong chassis that defines the seat and cockpit of a modern Indy car. In 2000 and 2001, a series of fatal crashes in stock car racing created great concern for improving the crash protection for drivers in those racecars. Unlike the Indy car, the typical racing stock car features a more spacious driver cockpit due to its resemblance to the shape of a passenger car. The typical racing seat used in stock cars did not have the same configuration or support characteristics of the Indy car seat, and five-point belt restraints were used. The tubular steel space frame chassis of a stock car also differs from an Indy car's composite chassis structure in both form and mechanical behavior. This paper describes the application of results of the biomechanical analysis of the Indy car crash studies to the unique requirements of stock car racing driver crash protection. Sled test and full-scale crash test data using both Hybrid III frontal crash anthropomorphic test devices (ATDs) and BioSID side crash ATDs for the purpose of evaluating countermeasures involving restraint systems, seats and head/neck restraints has been instrumental in guiding these developments. In addition, the development of deformable walls for oval tracks (the SAFER Barrier) is described as an adjunct to improved occupant restraint through control of the crash forces acting on a racing car. NASCAR (National Association for Stock Car Auto Racing, Inc) implemented crash recording in stock car racing in its three national series in 2002. Data from 2925 crashes from 2002 through the 2005 season are summarized in terms of crash severity, crash direction, injury outcome, and protective system performance.
Nanoscale Bioreceptor Layers Comprising Carboxylated Polythiophene for Organic Electrochemical Transistor-Based Biosensors (2021)

We investigated the carboxylated conjugated polymer poly 3-(3-carboxypropyl)thiophene-2,5-diyl as a nanosized (200–350 nm) biomolecule receptor layer on the channel of organic electrochemical transistor (OECT) devices. Myelin basic protein, SARS-CoV-2 spike glycoprotein S1, and their antibodies (10 nm size scale) were alternately used in the attached molecule form as receptors and analytes. Sub-ng detection in buffer was observed, and response to S1 was also obtained in clinical serum. Changes in threshold voltage and current output from OECT transfer curves and measurements of open circuit potential between receptor layers and a reference electrode provided complementary responses and insight into the response mechanisms, guiding further development of electrochemical field-effect and voltammetric protein sensors based on polymeric active layers with nanoscale functionality.
Sub 8-Bit Quantization of Streaming Keyword Spotting Models for Embedded Chipsets (2022)

We propose a novel 2-stage sub 8-bit quantization aware training algorithm for all components of a 250K parameter feedforward, streaming, state-free keyword spotting model. For the 1st-stage, we adapt a recently proposed quantization technique using a non-linear transformation with tanh(.) on dense layer weights. In the 2nd-stage, we use linear quantization methods on the rest of the network, including other parameters (bias, gain, batchnorm), inputs, and activations. We conduct large scale experiments, training on 26,000 hours of de-identified production, far-field and near-field audio data (evaluating on 4,000 hours of data). We organize our results in two embedded chipset settings: a) with commodity ARM NEON instruction set and 8-bit containers, we present accuracy, CPU, and memory results using sub 8-bit weights (4, 5, 8-bit) and 8-bit quantization of rest of the network; b) with off-the-shelf neural network accelerators, for a range of weight bit widths (1 and 5-bit), while presenting accuracy results, we project reduction in memory utilization. In both configurations, our results show that the proposed algorithm can achieve: a) parity with a full floating point model's operating point on a detection error tradeoff (DET) curve in terms of false detection rate (FDR) at false rejection rate (FRR); b) significant reduction in compute and memory, yielding up to 3 times improvement in CPU consumption and more than 4 times improvement in memory consumption.
Tetrahedral and Octahedral Extraframework Aluminum in Ultrastable Y Zeolites (1988)

It is shown by 27Al MAS-NMR that, besides tetrahedral framework Al (~60 ppm), extraframework pentacoordinated or tetrahedrally distorted Al (~30-40 ppm), and octahedral extraframework aluminum (~0 ppm), tetrahedral Al in amorphous silica-alumina is formed during the dealumination of Y zeolite, either by steam or by SiCl4 treatment. This silica-alumina show characteristic hydroxyl groups at 3600-3610 cm-1, with acid strength higher than that of zeolite framework hydroxyls. By mild acid or basic treatments it is possible to change the proportion of the different types of aluminum that affect the cracking of gas-oil. It has been found that in highly steam-dealuminated HY zeolites a radical, cracking mechanism increases the formation of C1 and C2 on HY zeolites with less than 5 Al per unit cell.
The role of compliance as a cause of instability in oral anticoagulant therapy (1997)

To assess the role of non-compliance as a cause of instability in patients on oral anticoagulant therapy, a follow-up study of stably and instably anticoagulated patients and of patients beginning oral anticoagulant therapy was performed. Compliance was assessed by pill counting and with the use of pill bottles in the cap of which a microprocessor registered the exact date and time of opening of the bottle. (In)stability of oral anticoagulant therapy was expressed as the number of INRs and as the time spent within the target range and by squared sigma. Subsequently, as a pilot study, a randomized intervention study in instable, non-compliant patients was performed in which these patients were or were not informed about the real nature of the cap of the pill bottle. Nineteen stable and 19 unstable patients and 30 patients beginning therapy were followed for 3 months or less until therapy stopped. Compliance was better in the previously stably anticoagulated patients, although differences were small. Poor compliance was not a major cause of instability in patients starting therapy. Although the pilot intervention study was too small to assess the role of the special pill bottle, it was shown that compliance can be positively affected.