gebhart/patrepeval huggingface dataset:
Isotope-differentiated binding energy shift tags (IDBEST™) for improved targeted biomarker discovery and validation (2004)

Mass spectrometry has proved to be an important tool for protein biomarker discovery, identification and characterization. However, global proteomic profiling strategies often fail to identify known low-abundance biomarkers as a result of the limited dynamic range of mass spectrometry (two to three orders of magnitude) compared with the large dynamic range of protein concentrations in biologic fluids (11 to 12 orders of magnitude for serum). In addition, the number of peptides generated in such methods vastly overwhelms the resolution capacity of mass spectrometers, requiring extensive sample clean-up (e.g., affinity tag, retentate chromatography and/or high-performance liquid chromatography) before mass spectrometry analysis. Baiting and affinity pre-enrichment strategies, which overcome the dynamic range and sample complexity issues of global proteomic strategies, are very difficult to couple to mass spectrometry. This is due to the fact that it is nearly impossible to sort target peptides from those of the bait since there will be many cases of isobaric peptides. IDBEST (Target Discovery, Inc.) is a new tagging strategy that enables such pre-enrichment of specific proteins or protein classes as the resulting tagged peptides are distinguishable from those of the bait by a mass defect shift of approximately 0.1 atomic mass units. The special characteristics of these tags allow: resolution of tagged peptides from untagged peptides through incorporation of a mass defect element; high-precision quantitation of up- and downregulation by using stable isotope versions of the same tag; and potential analysis of protein isoforms through more complete peptide coverage from the proteins of interest.
Visualization of Injection Moulding Process (2008)

A special tool-transparent mould designed to visualize the melt flow inside the cavity is used in this research. The aim of the work is to assess the polymer melt behavior under different processing conditions-close to industrial, in conventional and two materials non-conventional injection moulding techniques. The mould is designed with two injection locations and has possibility to change the geometry of the cavity in order to investigate the melt behavior in differently shaped cavities. Visual access in the mould is allowed by the sapphire windows, surrounding the cavity. For image acquisition a high speed video camera NAC 1000 is used. Materials used in the research are three polypropylenes with different flow index. Results are obtained for conventional injection moulding, two material monosandwich and two material biinjection moulding. Apart from visualization, instrumentation of the mould allows to be obtained PT data for each processing condition. Results from conventional injection moulding are compared with MPI5.0 simulations.
Expeditious Synthesis of Imidazo[1,2‐c]pyrimidines via a [4 + 1]‐Cycloaddition. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Abstract 1947: FAM129B regulates cell proliferation and activates NF-κB and Nrf2 by inactivating KEAP1 in cancer cells (2011)

Abstract The Family with sequence similarity 129 (FAM129) contains three membrane proteins, FAM129A, B and C. FAM129A (also called Niban) and FAM129C (also called BCNP1) have been found to be up-regulated in thyroid tumors and chronic lymphocytic leukemia, respectively. Although phosphorylation of FAM129B has been suggested to play a role in controlling melanoma cell invasion, the molecular mechanism of FAM129B in tumorigenesis remains largely unknown. In this study, we first identified FAM129B as one of proteins with altered phosphorylation status in breast cancer stem cells by the phosphor-mass spectrum technique. Silencing of FAM129B expression in breast cancer cell line, MDA-MB-231, led to decreased proliferation, along with flattened and rounded cell morphology. By mammalian two-hybrid system and FRET (fluorescence resonance energy transfer) assay, KEAP1 (kelch-like ECH-associated protein 1) was detected to interact with FAM129B. KEAP1 has been reported to function as a substrate adaptor protein for Cul3-dependent E3 ligase complex to repress IKKβ and transcription factor Nrf2. We indeed observed that the expression of NF-κB and Nrf2 downstream genes, FN1 and NQO1, was down-regulated in FAM129B-silenced cells by qPCR analysis. On the other hand, FAM129B together with either IKKβ or Nrf2 synergistically activated NF-κB and Nrf2 promoter activity by reporter assays. Taken together, our results suggest that FAM129B might play an important role in the regulation of cell proliferation in cancers by inactivating KEAP1 which in turn activates Nrf2 and IKKβ activities. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1947. doi:10.1158/1538-7445.AM2011-1947
Analysis of Urban Millimeter Wave Microcellular Networks (2016)

Millimeter wave (mmWave) networks are sensitive to blockages due to buildings in urban areas. This is critical for vehicle-to-infrastructure networks which are cellular networks designed to support emerging vehicular applications. Motivated by measurement and ray tracing results in urban microcells, instead of characterizing the pathloss by Euclidean distance, we calculate it by the weighted sum of segment length along the propagation path, i.e., Manhattan distance, and a certain corner loss at the intersections along the path. We analyze network performance by modeling the urban microcell network by a Manhattan Poisson line process. Our results show significant differences between Manhattan and Euclidean distance- based pathloss models. Assuming the receiver is associated with the base station (BS) with the smallest pathloss, we derive closed-form expression of the distribution of the associated link pathloss. We obtain the coverage probability and reveal the impacts of interference from the LOS and NLOS BSs. It is shown that in this scenario the interference from a NLOS parallel street is negligible.
Processus ponctuels marqués pour l'extraction automatique de caricatures de bâtiments à partir de modèles numériques d'élévation (2004)

The context of this thesis is the reconstruction of urban areas from images. It proposes a set of algorithms for extracting simple shapes from Digital Elevation Models (DEM). DEMs describe the altimetry of an urban area by a grid of points, each of which has a height associated to it. The proposed models are based on marked point processes. These mathematical objects are random variables whose realizations are configurations of geometrical shapes. Using these processes, we can introduce constraints on the shape of the objects to be detected in an image, and a regularizing term incorporating geometrical interactions between objects. An energy can be associated to each object configuration, and the global minima of this energy can then be found by applying simulated annealing to a Reversible Jump Monte Carlo Markov Chain sampler (RJMCMC). We propose four different models for extracting the outlines of buildings from altimetric descriptions of dense urban areas. Each of these models is constructed from an object shape, a data energy, and a regularizing energy. The first two models extract simple shapes (rectangles) using, respectively, a homogeneity constraint and discontinuity detection. The third model looks for three-dimensional polyhedral buildings. The last model uses cooperation between two types of objects, rectangles and segments. The resulting algorithms are evaluated on real data provided by the French National Geographic Institute (a laser DEM and optical DEMs of differing quality).
DSP-based robust force and compliance control of DD motor (2002)

The authors propose the robust force and control of a DD motor based on a novel model following acceleration control. The model following acceleration control system has the ability to suppress the state error caused by not only force disturbance but also system structure variations. The DD motor controlled by the proposed acceleration control system is treated as a structure of two integral elements, which has no mechanical system parameter. Therefore, each joint of a DD robot manipulator is regulated by an acceleration command. The proposed acceleration control system is designed using H/sup infinity / control theory, and it is realized by a DSP (digital signal processor) software algorithm. Experimental results show that the proposed method is valid for the robust force and compliance control system of a DD robot manipulator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Current status and future directions in the management of chronic hepatitis C (2012)

Hepatitis C virus (HCV) is endemic worldwide, and it causes cirrhosis and other complications that often lead to death; nevertheless, our knowledge of the disease and its mechanisms is limited. HCV is most common in underdeveloped nations, including many in Africa and Asia. The virus is usually transmitted by parenteral routes, but sexual, perinatal, and other types of transfer have been known to occur. Approximately 80% of individuals who contract hepatitis C develop a chronic infection, and very few are able to spontaneously clear the virus. Because hepatitis C is asymptomatic in the majority of patients, the presence of HCV RNA in the serum is the best diagnostic tool. Although serious complications from hepatitis C may not occur for 20 years, 1/5 of chronic patients eventually develop life - threatening cirrhosis. More research is needed on the different therapy options for the disease, and many factors, most importantly the genotype of the virus, must be taken into account before beginning any treatment. As there is no vaccine against HCV at present, the most effective and recommended therapy is pegylated-interferon-α-2a plus ribavirin. While interferon is marginally effective as a monotherapy, both adding the moiety and combining it with ribavirin have been shown to dramatically increase its potency. While there are numerous alternative and complementary medicines available for patients with hepatitis C, their efficacy is questionable. Currently, research is being done to investigate other possible treatments for hepatitis C, and progress is being made to develop a vaccine against HCV, despite the many challenges the virus presents. Until such a vaccination is available, prevention and control methods are important in containing and impeding the spread of the virus and mitigating its deleterious effects on the health of people and communities worldwide.
Quantum-Secure Message Authentication Codes. (2012)

We construct the first Message Authentication Codes (MACs) that are existentially unforgeable against a quantum chosen message attack. These chosen message attacks model a quantum adversary’s ability to obtain the MAC on a superposition of messages of its choice. We begin by showing that a quantum secure PRF is sufficient for constructing a quantum secure MAC, a fact that is considerably harder to prove than its classical analogue. Next, we show that a variant of Carter-Wegman MACs can be proven to be quantum secure. Unlike the classical settings, we present an attack showing that a pair-wise independent hash family is insufficient to construct a quantum secure one-time MAC, but we prove that a four-wise independent family is sufficient for one-time security. Keywords: Quantum computing, MAC,chosen message attacks, post-quantum security 1
Carbon-Coated Core Shell Structured Copper and Nickel Nanoparticles Synthesized in an Ionic Liquid (2006)

A simple synthetic route to prepare carbon-coated copper or nickel nanoparticles is developed in an ionic liquid under microwave heating. The obtained products are characterized by XRD, UV-spectroscopy, and Raman spectroscopy. The morphologies are studied with the help of TEM, HRSEM, and HRTEM. A bulk transport property for carbon coated nickel is reported in this letter.
Removal of nitrate from industrial wastewaters in a pilot plant by nitrate-tolerantKlebsiella oxytoca CECT 4460 andArthrobacter globiformis CECT 4500 (1998)

Two strains, a gram-negative bacterium Klebsiella oxytoca CECT 4460 and a gram-positive, mycelium-forming bacterium Arthrobacter globiformis CECT 4500, tolerant to up to 1 M nitrate, were isolated from the grounds of a munitions factory. Under strict aerobic conditions and with appropriate C-sources, growth of these bacteria took place when the nitrate concentration in the medium was below 150 mM. Optimal growth conditions regarding the culture medium composition for the biological removal of nitrate were established in batch cultures. Then, the system was scaled up to a 40-L pilot plant and operated under continuous conditions in a factory with direct waste streams from dinitroethylene glycol production after appropriate dilution with nontreated groundwaters. The level of nitrate in the effluent was below 0.5% of the initial N-load. Nitrite and ammonium were undetectable and the level of the C-source in the effluent was below 50 mg per L. On the basis of these results, we conclude that the system worked on site satisfactorily. Copyright 1998 John Wiley & Sons, Inc.
Effects of 2D SiO[sub 2] Nanorod-Modified Substrates on the Morphology and CL Properties of ZnS:Mn Particle-like Thin-Film Phosphors (2005)

To improve light extraction from ZnS:Mn thin-film phosphors, we have studied the effects of introducing various two-dimensional (2D) nanorod arrays onto glass substrates. We determined the effects of 2D nanorods on the morphology and cathodoluminescence (CL) emissions of ZnS:Mn thin films with a view to optimizing the lattice constant of the array and the diameters of the nanorods. Particle-like thin-film phosphors were obtained from the sputtering growth of ZnS:Mn thin films on the nanorod-modified glass substrates, particularly for nanorods with higher aspect ratios and lower nanorod array density. We obtained a significant enhancement (a factor of ) of the CL extraction efficiency at the interface between ZnS and air, for low voltage electron beam excitation of ZnS:Mn thin-film phosphors deposited on 2D nanorod-modified substrates. This improvement in the extraction efficiency is due to the uniform and nanoscale particle-like morphology of these thin-film phosphors, as well as to the diffraction scattering produced by the 2D periodic nanorod array.
An Improved Patient-Specific Mortality Risk Prediction in ICU in a Random Forest Classification Framework (2015)

Dynamic and automatic patient specific prediction of the risk associated with ICU mortality may facilitate timely and appropriate intervention of health professionals in hospitals. In this work, patient information and time series measurements of vital signs and laboratory results from the first 48 hours of ICU stays of 4000 adult patients from a publicly available dataset are used to design and validate a mortality prediction system. An ensemble of decision trees are used to simultaneously predict and associate a risk score against each patient in a k-fold validation framework. Risk assessment prediction accuracy of 87% is achieved with our model and the results show significant improvement over a baseline algorithm of SAPS-I that is commonly used for mortality prediction in ICU. The performance of our model is further compared to other state-of-the-art algorithms evaluated on the same dataset.
Sidewall Modification of Porous SiOCH Induced by Etching and Post Etching Plasma Treatments (2010)

International audience
Seq-ing the SINEs of Central Nervous System Tumors in Cerebrospinal Fluid DNA (2022)

Abstract Lesions within the brain cavity pose critical challenges for diagnostics, particularly distinction between cancerous and non-cancerous lesions. We here introduce an analytic technique called Real-CSF to detect cancers of the central nervous system from evaluation of DNA in the cerebrospinal fluid (CSF). Short interspersed nuclear elements (SINEs) from throughout the genome are PCR-amplified with a single primer pair and the PCR products are evaluated by next generation sequencing. Real-CSF uses machine learning to assess three features from the sequencing data – gains or losses of 39 chromosome arms, focal amplifications, and somatic nucleotide variants. Real-CSF was applied to 282 CSF samples and correctly classified 71 % of 187 cancers and misclassified only 4.2% of 95 non-neoplastic lesions in the brain.
Hot Sale 5PCS Kitchen Enamel Cooking Pot Set (2010)

Hereditary hemochromatosis (HH) is characterized by increased intestinal iron absorption that may result in iron overload. Although phlebotomy is widely practiced,Bw Ends Cast Steel Pressure Seal Globe Valve, severe heart disease, or poor venous access, and compliance can vary. The once-daily, oral iron chelator, deferasirox (Exjade) may provide an alternative treatment option.Lab Cod Ammonia Nitrigen Test for Wastewater,Hand Plastic Welder HDPE Welding Rod-2000 ng/mL, transferrin saturation ≥ 45%, and no known history of cirrhosis were enrolled in this dose-Hot Sales High Quality Adjustable Oil Damper, comprising a core and an extension phase (each 24 weeks). Forty-Qi Wireless Car Charger with Magnetic Holder(n = 11), 10 (n = 15), or 15 (n = 23) mg/kg/day.Factory Price ISO14443A Printed NFC RFID Tag-dependent, the most common being diarrhea, headache, and nausea (n = 18, n = 10, and n = 8 in the core and n = 1, n = 1, and n = 0 in the extension, respectively).Sit up Pad Abdominal Exercise Trainer Ab Mat/kg/day than in the 5 or 10 mg/kg/FTTH Mini Optical Receiver with 2 RF Outputs-week treatment period;Adjustable Flashing Roller Wheel Skate Shoes;Polyresin Religious Statue with Good Quality,Vodafast America Type Wing-Head Thumb Screws; 33%Translucent PP Corrugated Plastic Sheets 4X8. After receiving deferasirox for 48 weeks,1200W 1500W 1800W 2000W Plant LED Grow Light.5%, 74.8%, and 74.1% in the 5, 10, and 15 mg/kg/3.0L Professional Ultrasonic Cleaner Machine, respectively.23um Pet Film Non Corona Treated for Roofing,Yuxing Labels and Release Film for Furniture; 250 ng/mL. Conclusion Deferasirox doses of 5, 10, and 15 mg/kg/Conical Double Barrel and Screw for PVC Tube.Wcb/Wc6/Wc9 Cast Steel Flanged API Gate Valve, starting deferasirox at 10 mg/kg/Hot Sale European Style Leather Sofa .
Activation of SiO2‐supported zirconocene catalysts by common trialkylaluminiums (1993)

Abstract A modified SiO 2 was prepared by reacting SiO 2 with Cl 2 Si(CH 3 ) 2 in toluene, on which methylaluminoxane (MAO) was supported to obtain a catalyst precursor. The mixture of the precursor and Cp 2 ZrCl 2 (Cp: cyclopentadienyl) gave polyethylene in a high yield even by using common trialkylaluminiums as cocatalyst. Surprisingly, the MAO‐free catalyst system composed of the modified SiO 2 and Cp 2 ZrCl 2 was also found to be activated by common trialkylaluminiums.
Total synthesis of dl-shionone, a tetracyclic triterpene (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of dl-shionone, a tetracyclic triterpeneRobert E. Ireland, Christopher A. Lipinski, Conrad J. Kowalski, Jefferson W. Tilley, and David M. WalbaCite this: J. Am. Chem. Soc. 1974, 96, 10, 3333–3335Publication Date (Print):May 1, 1974Publication History Published online1 May 2002Published inissue 1 May 1974https://pubs.acs.org/doi/10.1021/ja00817a061https://doi.org/10.1021/ja00817a061research-articleACS PublicationsRequest reuse permissionsArticle Views422Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Continuous ablation improves lesion maturation compared with intermittent ablation strategies (2020)

Continuous RFA delivery resulted in larger and deeper lesions with higher tissue temperatures compared with interrupted ablation. This study may have implications for high-power short duration ablation strategies, motivates strategies to reduce variations in ablation delivery, and provides an upper limit for ablation duration beyond which power delivery has diminishing returns.
Low Birth Weight and Retinal Vascular Caliber in Young Children (2008)

To the Editor —

Tapp et al1 report interesting associations of low birth weight with several retinal circulatory measures. These findings support the hypothesis that a person's risk of cardiovascular disease may have its etiologic origins in early life. It is of importance that these data also suggest that retinal image analysis may offer a unique means to quantify the adverse effects of early life factors on the microvasculature in young children.

We have previously examined retinal vascular caliber changes …
Abstract 16928: Fragmented Care Following Transcatheter Aortic Valve Replacement is Associated With Increased 1-year Mortality and Readmission (2017)

Background: Postoperative fragmented care following elective surgery has been associated with poor outcome. The association between fragmented care and outcomes among patients undergoing transcathe...
Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule (2017)

Human ribonucleotide reductase (hRR) is crucial for DNA replication and maintenance of a balanced dNTP pool, and is an established cancer target. Nucleoside analogs such as gemcitabine diphosphate and clofarabine nucleotides target the large subunit (hRRM1) of hRR. These drugs have a poor therapeutic index due to toxicity caused by additional effects, including DNA chain termination. The discovery of nonnucleoside, reversible, small-molecule inhibitors with greater specificity against hRRM1 is a key step in the development of more effective treatments for cancer. Here, we report the identification and characterization of a unique nonnucleoside small-molecule hRR inhibitor, naphthyl salicylic acyl hydrazone (NSAH), using virtual screening, binding affinity, inhibition, and cell toxicity assays. NSAH binds to hRRM1 with an apparent dissociation constant of 37 µM, and steady-state kinetics reveal a competitive mode of inhibition. A 2.66-Å resolution crystal structure of NSAH in complex with hRRM1 demonstrates that NSAH functions by binding at the catalytic site (C-site) where it makes both common and unique contacts with the enzyme compared with NDP substrates. Importantly, the IC<sub>50</sub> for NSAH is within twofold of gemcitabine for growth inhibition of multiple cancer cell lines, while demonstrating little cytotoxicity against normal mobilized peripheral blood progenitor cells. NSAH depresses dGTP and dATP levels in the dNTP pool causing S-phase arrest, providing evidence for RR inhibition in cells. This report of a nonnucleoside reversible inhibitor binding at the catalytic site of hRRM1 provides a starting point for the design of a unique class of hRR inhibitors.