gebhart/patrepeval huggingface dataset:
A phase I trial of antifibronecitin 131I-L19-small immunoprotein (L19-SIP) in solid tumors and lymphoproliferative disease (2008)

2575 Background: L19-SIP is a human recombinant antibody-fragment consisting of the variable regions of the L19 mAb directed against the extra-domain B (ED-B) of fibronectin that is overexpressed in tumoral vasculature. We explored the targeting potential of 131I-L19-SIP for both tumor imaging and radioimmunotherapy (RIT). Methods: 131I-L19-SIP (4 mg; 74–193 MBq) was administered iv for dosimetry and pharmacokinetics (PK). Patients (pts) with high tumor uptake (lesion/red marrow absorbed dose ratio ≥10) received a single therapeutic dose of about 3,700 MBq (n=11) or 5,550 MBq (n=7) of 131I-L19-SIP. Dosimetry was based on dual-head gamma-camera planar imaging. Results: 37 pts (median age 59 yr [range 34–82], median ECOG PS 0 [range 0–1], median prior chemotherapies 2 [range 0–5]) with the following cancers were enrolled: colorectal (8), melanoma (7), thymoma (4), mesothelioma (4), prostate (2), pancreatic (2), lymphomas (2), other (8). Eighteen pts (48.6%) were eligible for RIT. Blood elimination profile in the first 13 pts: T1/2α 13 h, T1/2 β 39 h, with an extremely low interpatient variability. Dosimetry estimates as median absorbed doses (Gy): heart wall 2.8, kidneys 3.7, liver 3.0, lungs 1.98, testes 4.2, stomach 0.67, red marrow 0.85, tumor lesions 12.24. Imaging was excellent and in some cases revealed lesions undetected by MRI or CT. Main toxicities of RIT: short-lived grade 3/4 thrombocytopenia (4 pts) and uncomplicated grade 4 neutropenia (1 pt). One objective response was recorded according to RECIST criteria. A clinical benefit was seen in 4 additional pts: stabilization of ≥3 months in 1 thymoma pt, clinical evidence of long-term tumor shrinkage in 1 melanoma pt, stabilization of rapidly progressive skin lesions in 1 melanoma pt, and pain palliation in 1 breast cancer pt with brachial plexus neoplastic infiltration. Furthermore, a substantial decrease of [18F]FDG uptake was observed for several lesions in 3 out of 4 mesothelioma pts. Conclusions: Good tolerability and high tumor uptake combined with low red marrow absorbed dose justify testing the feasibility of further increase of the 131I-L19-SIP dose for RIT. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Bayer HealthCare Pharma, USA
Rational optimization of tolC as a powerful dual selectable marker for genome engineering (2014)

Selection has been invaluable for genetic manipulation, although counter-selection has historically exhibited limited robustness and convenience. TolC, an outer membrane pore involved in transmembrane transport in E. coli, has been implemented as a selectable/counter-selectable marker, but counter-selection escape frequency using colicin E1 precludes using tolC for inefficient genetic manipulations and/or with large libraries. Here, we leveraged unbiased deep sequencing of 96 independent lineages exhibiting counter-selection escape to identify loss-of-function mutations, which offered mechanistic insight and guided strain engineering to reduce counter-selection escape frequency by ∼40-fold. We fundamentally improved the tolC counter-selection by supplementing a second agent, vancomycin, which reduces counter-selection escape by 425-fold, compared colicin E1 alone. Combining these improvements in a mismatch repair proficient strain reduced counter-selection escape frequency by 1.3E6-fold in total, making tolC counter-selection as effective as most selectable markers, and adding a valuable tool to the genome editing toolbox. These improvements permitted us to perform stable and continuous rounds of selection/counter-selection using tolC, enabling replacement of 10 alleles without requiring genotypic screening for the first time. Finally, we combined these advances to create an optimized E. coli strain for genome engineering that is ∼10-fold more efficient at achieving allelic diversity than previous best practices.
Natural gas conversion VI : proceedings of the 6th International Natural Gas Conversion Symposium, June 17-22, 2001, Alaska, USA (2001)

Impact of syngas generation technology selection on a GTL FPSO (C. Lowe et al.). Methane conversion via microwave plasma initiated by a metal initiator (Y. Xu et al.). Mechanism of carbon deposit/removal in methane dry reforming on supported metal catalysts (K. Nagaoka et al.). Catalyst-assisted oxidative dehydrogenation of light paraffins in short contact time reactors (A. Beretta, P. Forzatti). Catalytic dehydrogenation of propane over a PtSn/SiO2 catalyst with oxygen addition: selective oxidation of H2 in the presence of hydrocarbons (L. Late et al.). Hydroconversion of a mixture of long chain n-paraffins to middle distillate: effect of the operating parameters and products properties (V. Calemma et al.). Decomposition/reformation processes and CH4 combustion activity of PdO over Al2O3 supported catalysts for gas turbine applications (G. Groppi et al.). Lurgi's mega-methanol technology opens the door for a new era in down-stream applications (J. Haid, U. Koss). Expanding markets for GTL fuels and specialty products (P.F. Schubert et al.). Some critical issues in the analysis of partial oxidation reactions in monolith reactors (S.C. Reyes et al.).
Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults (2013)

The HIV-infected older adult (HOA) community is particularly vulnerable to cognitive impairment. Previous studies in the general older adult population have reported that lower scores on tests of cognitive function often correlate negatively with aerobic fitness [5-7]. HIV-infected individuals have significantly reduced aerobic fitness and physical function compared to HIV-uninfected individuals. Determining important correlates of cognitive ability may be beneficial in not only detecting precursors to future cognitive impairments, but also target areas for interventions. The purpose of this study was to investigate the relationship between cognitive ability and aerobic fitness in HIV-infected older adults. We conducted a cross-sectional study of HOA on antiretroviral therapy (ART) >50 years of age. Domain specific cognitive function was assessed by means of a neuropsychological battery. Aerobic fitness (VO2peak) was assessed using a graded, progressive treadmill test. Thirty-seven HOA on ART (mean±SD: age 59±6 years, BMI 28±5, CD4 663±337 cells/ml, duration since HIV diagnosis 17±7 years; 81% males) completed the cognitive tests. Several domains of cognition were significantly associated with VO2peak by Spearman correlation analysis (p<0.05). By step-wise adjusted regression VO2peak was most frequently and significantly related to many cognitive domains such as verbal and visual memory, visual perception, and language (p<0.05). We found that participants with higher Vo2peak were less likely to have more severe forms of HIV-associated neurocognitive disorders (HAND) such as mild neurocognitive disorder (OR=0.65; p=0.01) and HIV-associated dementia (OR=0.64; p=0.0006). In HOA and in conclusion, aerobic fitness is related to cognitive performance on various tasks. The likelihood of cognitive impairment increased with lower fitness levels. Therefore, increased fitness may serve an important factor in maintenance of cognition and neural integrity for aging HIV-infected individuals. Future prospective and large scale studies are needed to evaluate the effect of fitness and vascular stiffness and function on cognition and brain structure among HOA.
Asymmetric Radical Cyclization Reactions of Axially Chiral N‐Allyl‐o‐iodoanilides to Form Enantioenriched N‐Acyl Dihydroindoles. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
ACYCLIC/CARBOCYCLIC GUANOSINE ANALOGUES AS ANTI-HERPESVIRUS AGENTS (2001)

Several guanosine analogues, i.e. acyclovir (and its oral prodrug valaciclovir), penciclovir (in its oral prodrug form, famciclovir) and ganciclovir, are widely used for the treatment of herpesvirus [i.e. herpes simplex virus type 1 (HSV-1), and type 2 (HSV-2), varicella-zoster virus (VZV) and/or human cytomegalovirus (HCMV)] infections. In recent years, several new guanosine analogues have been developed, including the 3-membered cyclopropylmethyl and -methenyl derivatives (A-5021 and synguanol) and the 6-membered D- and L-cyclohexenyl derivatives. The activity of the acyclic/carbocyclic guanosine analogues has been determined against a wide spectrum of viruses, including the HSV-1, HSV-2, VZV, HCMV, and also human herpesviruses type 6 (HHV-6), type 7 (HHV-7) and type 8 (HHV-8), and hepatitis B virus (HBV). The new guanosine analogues (i.e. A-5021 and D- and L-cyclohexenyl G) were found to be particularly active against those viruses (HSV-1, HSV-2, VZV) that encode for a specific thymidine kinase (TK), suggesting that their antiviral activity (at least partially) depends on phosphorylation by the virus-induced TK. Marked antiviral activity was also noted with A-5021 against HHV-6 and with D- and L-cyclohexenyl G against HCMV and HBV. The antiviral activity of the acyclic/carbocyclic nucleoside analogues could be markedly potentiated by mycophenolic acid, a potent inhibitor of inosine 5'-monophosphate (IMP) dehydrogenase. The new carbocyclic guanosine analogues (i.e. A-5021 and D- and L-cyclohexenyl G) hold great promise, not only as antiviral agents for the treatment of herpesvirus infections, but also an antitumor agents for the combined gene therapy/chemotherapy of cancer, provided that (part of) the tumor cells have been transduced by the viral (HSV-1, VZV) TK gene.
Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode (2019)

General control nonderepressible 2 (GCN2) is a master regulator kinase of amino acid homeostasis and important for cancer survival in the tumor microenvironment under amino acid depletion. We initiated studies aiming at the discovery of novel GCN2 inhibitors as first-in-class antitumor agents and conducted modification of the substructure of sulfonamide derivatives with expected type I half binding on GCN2. Our synthetic strategy mainly corresponding to the αC-helix allosteric pocket of GCN2 led to significant enhancement in potency and a good pharmacokinetic profile in mice. In addition, compound <b>6d</b>, which showed slow dissociation in binding on GCN2, demonstrated antiproliferative activity in combination with the asparagine-depleting agent asparaginase in an acute lymphoblastic leukemia (ALL) cell line, and it also displayed suppression of GCN2 pathway activation with asparaginase treatment in the ALL cell line and mouse xenograft model.
Studies on structural, electrical, and optical properties of Cu doped As–Se–Te chalcogenide glasses (2007)

Cu doped chalcogenide (ChG) glassy films in the As–Se–Te glass system have been prepared using thermal evaporation techniques. Single-source evaporation from bulk (1−x) As0.40Se0.35Te0.25+x Cu glasses with x=0.05, 0.075, 0.10, 0.125, and 0.15, as well as dual-source coevaporation from As-chalcogenide and Cu-chalcogenide binary glasses as source materials, has been explored. We have shown that it is not possible to deposit high concentration Cu doped ChG glassy films, from the Cu doped bulk samples using single-source evaporation. However, using the dual-source coevaporation technique, we have demonstrated that the films can be doped with high concentrations of Cu. Micro-Raman spectroscopy has been utilized to verify that Cu is introduced into the glass network without disrupting the basic As-chalcogen units. Optical measurements have shown that introduction of Cu decreases the band gap of As–Se–Te glasses. The electrical properties of the investigated films have been measured at different temperatures and it has been shown that Cu incorporation in the As–Se–Te glass system vastly improves electrical conductivity. Moreover, we have shown that the temperature dependence of electrical conductivity can be fitted assuming variable range hopping between states near the Fermi level.
Comparison of aneuploidy rates between conventional in vitro fertilization and intracytoplasmic sperm injection in in vitro fertilization–intracytoplasmic sperm injection split insemination cycles (2020)

Blastocysts created with conventional IVF and ICSI using sibling oocytes had similar rates of aneuploidy and mosaicism as examined using 24-chromosome screening. It is unlikely that conventional IVF caused significant contamination during PGT-A. We recommend conventional IVF as the preferred insemination method in PGT-A cycles, and ICSI should be indicated only in cases of male-factor infertility.
Influence of Surface and Structural Variations in Donor–Acceptor–Donor Sensitizers on Photoelectrocatalytic Water Splitting (2021)

Conjugated organic chromophores composed of linked donor (D) and acceptor (A) moieties have attracted considerable attention for photoelectrochemical applications. In this work, we compare the optoelectronic properties and photoelectrochemical performance of two D-A-D structural isomers with thiophene-<i>X</i>-carboxylic acid (<i>X</i> denotes 3 and 2 positions) derivatives and 2,1,3-benzothiadiazole as the D and A moieties, respectively. 5,5'-(Benzo[<i>c</i>][1,2,5]thiadiazole-4,7-diyl)bis(thiophene-3-carboxylic acid), <b>BTD1</b>, and 5,5'-(benzo[<i>c</i>][1,2,5]thiadiazole-4,7-diyl)bis(thiophene-2-carboxylic acid), <b>BTD2</b>, were employed in the study to understand how structural isomers affect surface attachments within chromophore-catalyst assemblies and their influence on charge-transfer dynamics. Crystal structures revealed that varying the position of the -COOH anchoring group causes the molecules to either contort out of a plane (<b>BTD1</b>) or adopt a near-perfect planar conformation (<b>BTD2</b>). <b>BTD1</b> and <b>BTD2</b> were co-loaded with either a water oxidation catalyst, [Ru(2,6-bis(1-methylbenzimidazol-2-yl)pyridine)-(4,4'-((HO)<sub>2</sub>OPCH<sub>2</sub>)<sub>2</sub>-2,2'-bipyridine)(OH<sub>2</sub>)]<sup>2</sup>, <b>RuCt</b><sup><b>2+</b></sup>, or proton reduction catalyst [Ni(P<sub>2</sub><sup>Ph</sup>N<sub>2</sub><sup>C<sub>6</sub>H<sub>4</sub>CH<sub>2</sub>PO<sub>3</sub>H<sub>2</sub></sup>)<sub>2</sub>]<sup>2+</sup>, <b>NiCt</b><sup><b>2+</b></sup>, on oxide electrodes to facilitate photodriven water splitting reactions. Emission quenching measurements indicate that both <b>BTD1</b> and <b>BTD2</b> inject electrons into n-type SnO<sub>2</sub>|TiO<sub>2</sub> electrodes and holes into p-type NiO semiconductors from their respective excited states at high efficiencies >60%. Photocurrent densities of chromophore-catalyst assemblies obtained using linear sweep voltammetry (LSV) show that <b>BTD2</b>-sensitized photoanodes generate significantly more photocurrent than <b>BTD1</b>-sensitized electrodes; however, both exhibit similar performances at the photocathode. Photoelectrocatyltic measurements demonstrate that both <b>BTD1</b> and <b>BTD2</b> performed similarly, generating Faradaic efficiencies of 39 and 38% at the anode or 61 and 79% at the cathode. Transient absorption measurements suggest that the differences between the LSV and photoelectrocatalytic measurements result from the differences in quantum yields of the photogenerated redox equivalents, which is also a reflection of the varying metal oxide surface conformation. Our findings suggest that <b>BTD2</b> should be investigated further in photocathodic studies since it has the structural advantage of being incorporated into diverse types of chromophore-catalyst assemblies.
Session 23 overview: Short-reach links, XCVR techniques, & PLLs (2013)

Lists the sessions held at the conference proceedings.
Simulation of SLI Lead-Acid Batteries for SoC, Aging and Cranking Capability Prediction in Automotive Applications (2012)

SLI lead-acid batteries are still the most commonly used technology in automotive applications around the world. Despite its relatively low gravimetric and volumetric energy density in comparison with other battery solutions it is still installed in the newest micro-hybrid and conventional cars due to its low cost. To facilitate the design of multi-physical systems as complex as modern automobiles, it is critical to have a precise battery aging model that incorporates various operation conditions. This paper presents an aging model that provides crucial information about state of health of SLI battery during lifetime for any conditions like climate, driving style, charging strategy or different battery management approaches. Described model is based both on empirical and physico-chemical solutions and can be calibrated to simulate any SLI lead-acid battery without design limitations.
Identification of Actionable Fusions as an Anti-EGFR Resistance Mechanism Using a Circulating Tumor DNA Assay (2019)

Diverse and potentially actionable fusions can be detected using a circulating tumor DNA assay in patients with advanced colorectal cancer. Distribution of coexisting subclonal mutations in <i>EGFR</i>, <i>KRAS</i>, and <i>NRAS</i> in a subset of the patients with fusion-present colorectal cancer suggests that these fusions may arise as a novel mechanism of resistance to anti-EGFR therapies in patients with metastatic colorectal cancer.
MICROFABRICATED SUBSTRATES FOR THE REMOTE GENERATION OF PRECISION FORCES ON SINGLE CELLS VIA INTRACELLULAR MAGNETIC FLUORESCENT NANOPARTICLES (2010)

A microfabrication process has been investigated and developed for the precision alignment of electroplated ferromagnetic elements with biological cells that are shaped by patterned fibronectin on transparent slides. In addition, we investigate one technique enabled by this process, which is the massively parallel generation of forces on single cells via internalized magnetic-fluorescent nanoparticles. Large magnetic field gradients generated by magnetizing the elements in close proximity to the cells allows the remote generation of large forces on single cells via intracellular localization of nanoparticles, which are capable of polarizing cell shape and activity.
Selective Dehydration of Sorbitol to Isosorbide over Sulfonated Activated Carbon Catalyst (2013)

불균일계 고체산 촉매인 설폰기(Sulfonyl Group) 함유 활성탄 촉매를 이용하여 솔비톨(Sorbitol)의 아이소소바이드로(Isosorbide)의 탈수반응을 수행하였다. 설폰화 반응(Sulfonation)에 의해 제조된 설폰화 활성탄 물질에 대해 대표적인 상업용 산촉매인 설폰화 지르코니아(Sulfated <TEX>$ZrO_2$</TEX>)와 산성 이온교환수지 Amberlyst-36과 솔비톨 탈수반응의 촉매활성을 비교하였다. 설폰화 활성탄 촉매를 이용하여 423.15 K에서 솔비톨의 탈수 반응 결과, 100% 솔비톨 전환율과 52% 아이소소바이드 선택도를 얻었다. 설폰화 활성탄은 낮은 설폰기 농도(0.5 mmol/g)에도 불구하고 높은 표면적으로 인해 423.15 K에서 Amberlyst-36과 유사한 솔비톨 탈수 반응 특성을 보이며, Amberlyst-36 대비 473.15 K 이상 고온에서도 안정한 특성을 보이는 고체산 촉매로 판단되었다. 또한, 솔비톨 탈수반응 결과를 바탕으로 반응과 생성물의 분리를 동시에 할 수 있는 반응증류 공정에 설폰화 활성탄 촉매를 적용한 결과, 기존 황산 공정 대비 2배 이상 빠른 반응시간에 단위 설폰산 농도 기준으로 4배 이상 높은 아이소소바이드 수율을 얻을 수 있었다. A sulfonated activated carbon (AC-<TEX>$SO_3H$</TEX>) was used as a solid acid catalyst for dehydration of sorbitol to isosorbide and its catalytic performance was compared with the commercial solid acid such as acidic ion exchange resin, Amberlyst-36, and sulfated copper oxide. The catalytic performance with 100% sorbitol conversion and 52% isosorbide selectivity was obtained over AC-<TEX>$SO_3H$</TEX> at 423.15 K. Although AC-<TEX>$SO_3H$</TEX> possessed only 0.5 mmol/g of sulfur content, it showed the similar dehydration activity of sorbitol to isosorbide with Amberlyst-36 (5.4 mmol/g) at 423.15 K. Based on the high thermal and chemical stability of AC-<TEX>$SO_3H$</TEX>, one-step reactive distillation, where isosorbide separation can be carried out simultaneously with sorbitol dehydration, was tried to increase the recovery yield of isosobide from sorbitol. The reactive distillation process using AC-<TEX>$SO_3H$</TEX>, the turnover number of AC-<TEX>$SO_3H$</TEX> was 4 times higher than the conventional two-step process using sulfuric acid.
Cellular Uptake of Ginsenosides in Korean White Ginseng and Red Ginseng and Their Apoptotic Activities in Human Breast Cancer Cells (2010)

Panax ginseng has been reported to have cancer-preventive properties and, through anti-inflammatory, antioxidant, and pro-apoptotic mechanisms, to influence gene expression. However, the comparison of Korean white ginseng (WG) and red ginseng (RG) in their apoptotic effects and the identification of the selective cellular uptake of the ginsenosides in human breast cancer cells have not yet been fully understood. In the present study, the relative nonpolar and protopanaxadiol (PPD) class ginsenosides exhibited more cytotoxic and efficient cellular uptake on MCF-7 cells compared with the relative polar and protopanaxatriol (PPT) class compounds. PPD class ginsenosides were present in RG in a 2.5 times higher concentration as compared to WG, while PPT class ginsenosides were only present in WG. Thus, RG exerted more potent cytotoxicity than WG against MCF-7 and MDA-MB231 cells. RG also increased the sub-G1 DNA contents of the cell cycle and Annexin V-positive apoptotic bodies undergoing apoptosis through the caspase-3 activation in MCF-7 cells. In addition, RG downregulated the proliferative and anti-apoptotic gene products and potentiated paclitaxel-induced apoptosis in MCF-7 cells. Overall, RG contained a higher concentration of PPD class ginsenosides as compared to WG; the greater cellular uptake of PPD resulted in more substantial antiproliferative activity in human breast cancer cells.
On the Origin of the 4.7 eV Absorption and 2.8 eV Emission Bands in Bulk AlN Substrates (2016)

One of the main limitations based on point defects in AlN is related to the UV absorption band present at 265 nm. This relatively broad absorption band limits the use of bulk substrates within the deep UV range and several complicated fabrication procedures have been devised to overcome this limitation. The origin for this absorption band along with corresponding photoluminescence signatures will be reviewed. C N - and V N + were identified as the point defects directly associated with the main absorption at 4.7 eV and the emission at 2.8 eV. The main absorption is due to a transition between the C N - state and conduction band, while the emission arises from a DAP transition between the donor V N + and acceptor C N - through the 4.7 eV excitation channel. New observations based on photoluminescence excitation are presented to further support the assignments previously made.
Efficiently Solving Wave Equation Migration on Multicore Processors (2008)

Summary This research explores the benefits of using multicore processors to reduce the time to solution for wave equation migration workloads. We implemented the core computation of a wave equation migration workload on the dual-core Intel Woodcrest Processor™ and the IBM Cell/B.E. Processor™. This work involved both the paralellization of the code over the cores and the SIMDization of the code on each core. As expected, this compute-bound kernel benefits from the additional compute power that these multicore processors provide; however we demonstrate that even in this compute-bound situation, one needs to efficiently manage the bandwidth requirements of the problem in order to achieve high performance. These optimizations led to performance increases of up to ~16x versus single core.