gebhart/patrepeval huggingface dataset:
Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice (2019)

GPR120 is implicated as a lipid receptor in the oro-sensory detection of dietary fatty acids. However, the effects of GPR120 activation on dietary fat intake or obesity are not clearly understood. We investigated to determine whether the binding of TUG891, a novel GPR120 agonist, to lingual GPR120 modulates fat preference in mice. We explored the effects of TUG891 on obesity-related hormones and conducted behavioral choice tests on mice to better understand the physiologic relevance of the action of TUG891. In cultured mouse and human taste bud cells (TBCs), TUG891 induced a rapid increase in Ca<sup>2+</sup> by acting on GPR120. A long-chain dietary fatty acid, linoleic acid (LA), also recruited Ca<sup>2+</sup> via GPR120 in human and mouse TBCs. Both TUG891 and LA induced ERK1/2 phosphorylation and enhanced in vitro release of glucagon-like peptide-1 from cultured human and mouse TBCs. In situ application of TUG891 onto the tongue of anesthetized mice triggered the secretion of pancreatobiliary juice, probably via the tongue-brain-gut axis. Furthermore, lingual application of TUG891 altered circulating concentrations of cholecystokinin and adipokines, associated with decreased circulating LDL, in conscious mice. In behavioral tests, mice exhibited a spontaneous preference for solutions containing either TUG891 or LA instead of a control. However, addition of TUG891 to a solution containing LA significantly curtailed fatty acid preference. Our study demonstrates that TUG891 binds to lingual GPR120 receptors, activates the tongue-brain-gut axis, and modulates fat preference. These findings may support the development of new fat taste analogs that can change the approach to obesity prevention and treatment.
ChemInform Abstract: UEBERPRUEFUNG DER STRUKTUR UND SYNTH. EINES NEUEN, AUS PILZEN ISOLIERTEN DIARYLAETHERS (1971)

Abstract Die Ullmann‐Kondensation des Phenols (I) mit dem Bromid (II) liefert den Diaryläther (IIIa), der zur Verbindung (IIIb) entbenzyliert wird.
Supplementary Movie 9 from Ovarian Cancer Spheroids Use Myosin-Generated Force to Clear the Mesothelium (2023)

&lt;p&gt;File Type: .mov; File Size: 1.5 MB.&lt;/p&gt;
Phase I trial of lorlatinib in combination with topotecan/cyclophosphamide in children with ALK-driven refractory or relapsed neuroblastoma: A new approaches to neuroblastoma therapy consortium study. (2022)

10041 Background: Lorlatinib, a macrocyclic ATP-competitive ALK inhibitor, exerts potent activity against neuroblastoma (NB) xenograftsharboring the most common ALK mutations. We performed a first-in-child phase 1 study of lorlatinib for patients with refractory/relapsed (R/R) ALK aberrant high-risk NB. We previously reported on Part A of the study, where safety of single agent lorlatinib was determined, showing complete responses (CR) to lorlatinib at the recommended phase 2 dose (RP2D) of 115 mg/m2 in pts &lt; 18 years and 150 mg in pts &gt; 18 yrs. Part B of the study aimed to determine the safety, pharmacokinetics (PK), RP2D, and explore the anti-tumor activity of lorlatinib in combination with topotecan and cyclophosphamide in pts with R/R ALK-driven NB. Methods: Patients with R/R NB ages 1-17 years with ALK mutations or amplification were eligible; prior ALK inhibitor (ALKi) treatment was allowed. Lorlatinib was orally administered once daily on days 1-28 with topotecan (0.75 mg/m 2 /day) and cyclophosphamide (250 mg/m 2 /day) administered intravenously days 1-5 and GCSF starting day 6. Two lorlatinib dose levels (DL) of 95 mg/m 2 /day (DL4B) and 115 mg/m 2 /day (DL5B) were assessed using a 3+3 dose escalation design with the primary endpoint of dose limiting toxicity (DLT) in Course 1. We report lorlatinib safety, PK, and objective response rate (ORR) for patients enrolled on Part B. Results: Between 10FEB2020 and 03DEC2021,9 eligible pts enrolled on Part B with a median age of 6.7 years (3.7-12.7). Three pts were enrolled onto DL4B and six onto DL5B (2/3 pts on DL4B and 4/6 pts on DL5B had received prior ALKi therapy) with no DLT’s observed in course 1. One patient on DL5B experienced a neuropsychological DLT in Course 3. Most common treatment-related adverse events were hematological, febrile neutropenia, high cholesterol, hypertriglyceridemia, and neuropsychological effects. The median number of courses received was 6 with a range of 1-8 on DL4B and 1-7 on DL5B. Of the 8 patients evaluable for response, ORR was 50%: 2/3 pts on DL4B and 2/5 pts on DL5B. Preliminary PK data demonstrate comparable dose level-associated lorlatinib steady state exposure between Part B chemotherapy combination and Part A monotherapy cohorts, supporting that chemotherapy had no effect on lorlatinib exposure that there are no overlapping toxicities. Conclusions: Lorlatinib in combination with topotecan and cyclophosphamide is well tolerated, and early data suggest encouraging objective anti-tumor activity. These data support the current integration of lorlatinib into up-front high risk neuroblastoma therapy for patients with ALK-driven neuroblastoma. Clinical trial information: NCT03107988.
Low‐intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults (2020)

In individuals with a sedentary lifestyle participating in a bicycle ergometry exercise program, maximal lipolysis and whole-body fat oxidation rate is reached in a fasted state during low-intensity exercise. For the first time, it was demonstrated that low-intensity exercise improves bioenergetics and increases fatty acid oxidation in PBMCs and may contribute to the anti-inflammatory phenotype.
‘Creating a culturally competent pharmacy profession’: A qualitative exploration of pharmacy staff perspectives of cultural competence and its training in community pharmacy settings (2023)

The Patient and Public Involvement and Engagement group at Newcastle University had input in the study design and conceptualisation. Two patient champions inputted to ensure that the study was conducted, and the findings were reported, with cultural sensitivity.
Supplementary Table S12 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers (2023)

&lt;p&gt;HPV42 consensus genomes.&lt;/p&gt;
Developing Secure Distributed Systems with CORBA (2002)

Part I CORBA security: introduction to CORBA - why CORBA?, the object management group (OMG), the object management architecture (OMA), the common object request broker architecture (CORBA), how does it all work together?, creating and running an example application the security basics - what is security?, why security?, aspects of security within CORBA, security management, threats, vulnerabilities, countermeasures, middleware security the CORBA security architecture - design goals, architectural components, secure CORBA on the Internet, conformance, features or wish list? Part II MICOSec: getting started with MICOSec - free software, MICO installation, MICOSec installation security level 1 - level 1 functionality, level 1 interface, a security-aware bank application example, implementation overview and conformance security level 2 - level 2 functionality overview, principal authentication and secure association object domain mapper for access control and audit access control security auditing delegation implementation overview and conformance security-unaware functionality - security-unaware functionality overview, principal authentication and secure association, object domain mapping, access control, security auditing, delegation, implementation overview and conformance.
A Novel Ex-Vivo Ureteral Apparatus for Assessing the Impact of Intraluminal Pharmaceutical Agents on Ureteral Physiology (2011)

With our apparatus, we can control the intraluminal and extraluminal ureteral environments, and measure peristalsis before and after drug administration. This apparatus should help investigators who are interested in studying both the diffusion of a wide range of drugs, as well as the effects of those medications on ureteral physiology. In this study, the urothelium acted as a significant barrier to the diffusion of nifedipine.
Sensitivity Analysis of Optical Metrics for Spectral Splitting Photovoltaic Systems: A Case Study (2015)

United States. Department of Defense. Assistant Secretary of Defense for Research & Engineering (Contract FA8721-05-C-0002)
Elucidation of Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy (2012)

A library of novel Mycobacterium tuberculosis type II dehydroquinase (DHQase) inhibitors were discovered through the use of a fragment elaboration approach. Putative active site binding fragments were initially assessed in silico which led to the selection of two small aromatic fragments for further investigation. Synthetic elaboration of the fragments provided a library of 34 inhibitors that exhibited low-micromolar inhibition of type II DHQase. A number of these inhibitors also showed antibacterial activity in the low-micromolar range in screens against M. tuberculosis in vitro; these now serve as lead compounds for further development of therapeutics for the treatment of tuberculosis.
Built-in Self Testing (BIST) of RF Performance in a System-on-Chip (SoC) (2006)

The advantages of having an on-chip system for measuring critical RF performance parameters are endless. With this capability, millions of ICs can be tested using a low cost tester while benefiting from an increase in test coverage and a reduction in test time and cost in a production environment. Another significant benefit is in the factory calibration procedures of critical device settings before deployment. Finally, this capability can allow the wireless terminal to periodically log performance results in flash memory from which they can be retrieved during the repair of a damaged unit easing debug analysis by the manufacturer. This paper presents a novel method of executing on-chip low-cost performance and compliance testing of a local oscillator and transmitter in a wireless transceiver. The presented techniques have been implemented and successfully tested in a Texas Instruments commercial 130 nm CMOS single-chip Bluetooth radio and are being redefined for the 90nm single-chip GSM radio.
Glycoamino Acid Analogues of the Thomsen–Friedenreich Tumor-Associated Carbohydrate Antigen: Synthesis and Evaluation of Novel Antiproliferative Factor Glycopeptides (2017)

Glycoamino acid analogues of the Thomsen-Friedenreich antigen disaccharide, where the 4' and 4″ hydroxyl groups were substituted with fluorine or hydrogen, were synthesized and incorporated into the asialylated antiproliferative factor (<i>as</i>-APF), a biologically active form of APF, a glycopeptide found in the urine of patients with interstitial cystitis. Various strategies were employed to incorporate the fluorine atom at the 4-positions of either the galactose or <i>N</i>-acetylgalactosamine unit of the disaccharide antigen, based on stereochemistry and reactivity. These glycopeptides were evaluated in antiproliferative assays on both primary normal bladder epithelial cells and T24 bladder carcinoma cells. Unlike many previously published substitutions to APF, mono-4'-fluorination of the GalNAc residue did not affect the activity, whereas fluoro-derivatives of the galactose 4″-position or both 4' and 4″ hydroxyls showed a reduced potency relative to the monosubstituted GalNAc derivative. A fourth compound where the 4″ position of galactose was deoxygenated showed a lower potency than the parent and monosubstituted compounds. These results suggest that specific substitutions in the sugar moieties in the APF can be tolerated, and the glycomimetic design of APF analogues can include fluorine in the GalNAc sugar of the disaccharide.
1539: Comparison of Light Spot Hydrophone (LSHD) and Fiber Optic Probe Hydrophone (FOPH) for Lithotripter Field Characterization (2006)

this retrospective analysis. Changes from baseline for specific urine parameters were compared. RESULTS: Patients using only L T (n = 63) sustained higher TV than those on PC (n = 37) at last visit (2.34 0.1 0 SE vs. 2.19 0.12 SE Lid, respectively). Urinary citrate increased and reached higher concentrations in those on L T (770 56 SE vs. 559 56 SE mg/d for L T and PC, respectively), but the difference from baseline to last visit was significant only in those on PC. The percentage of hypocitraturic patients that remained such after therapy was similar/group (73 and 80% for PC and L T groups, respectively). Urine pH in both groups exceeded 6 at baseline and throughout treatment. When patients' highest TV were compared to baseline, increases were more pronounced earlier in follow-up.
ChemInform Abstract: Metal Complexes of Azacrown Ethers in Molecular Recognition and Catalysis. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Use of the iTClamp versus standard suturing techniques for securing chest tubes: A randomized controlled cadaver study (2018)

The iTClamp was effective in securing TTs. The main benefit to the iTClamp is that minimal skill is required to adequately secure a TT to ensure that it does not become dislodged during transport to a trauma center.
Difference in susceptibility to MxA protein between a coxsackievirus B1 isolate and prototype, impact of serial cell culture passage (2010)

Human enteroviruses (EVs) cause a broad spectrum of acute and chronic diseases including meningitis and myocarditis. The type I interferon-induced MxA protein has been shown to inhibit the replication of an EV, coxsackievirus B4 (CVB4), but not cardioviruses such as encephalomyocarditis virus and mengo virus, members of the Picornaviridae family. EVs consist of more than 60 distinct serotypes against which the antiviral activity of MxA was not investigated yet. The main aim of this study was to explore the antiviral activity of MxA protein against a clinical CVB1 isolate and other EV prototypes. Vero cells expressing constituvely MxA protein were infected with EVs, and the percentage of inhibiton of expression of enteroviral RNA and capsid VP1 protein was determined. Following infection of MxA-transfected Vero cells with EVs, the expression of enteroviral RNA was inhibited by up to 99%, and that of VP1 protein by up to 85%. However, there was a difference in the percentage of MxA inhibition of EV replication between the different EV prototypes. This difference in MxA sensitivity was not due to a difference in the viral replication rates. The MxA protein was inactive against the clinical CVB1 isolate, and the replication rate of CVB1 isolate in MxA-transfected Vero cells was higher than that in mock-transfected Vero cells. A serial passage of the clinical CVB1 isolate and other EV prototypes resulted in an increase in their susceptibility to MxA protein. These results suggest the presence of MxA-resistant EV variants that may escape innate immunity and cause disease. J. Med. Virol. 82:424-432, 2010. (c) 2010 Wiley-Liss, Inc.
Supplementary table s2 from Predicting the Grade of Dysplasia of Pancreatic Cystic Neoplasms Using Cyst Fluid DNA Methylation Markers (2023)

&lt;p&gt;Supplementary Table S2. Characteristics of the discovery and validation sets.&lt;/p&gt;
Scaling Byzantine Fault-Tolerant Replication toWide Area Networks (2006)

This paper presents the first hierarchical Byzantine fault-tolerant replication architecture suitable to systems that span multiple wide area sites. The architecture confines the effects of any malicious replica to its local site, reduces message complexity of wide area communication, and allows read-only queries to be performed locally within a site for the price of additional hardware. A prototype implementation is evaluated over several network topologies and is compared with a flat Byzantine fault-tolerant approach
Adaptive acoustic echo cancellation microphone (1993)

In teleconferencing, speaker-phone systems have an annoying acoustic echo problem. The acoustic echo canceller using an adaptive transversal filter is an effective solution. However, very-high-order adaptive filters have computational and convergence problems. Furthermore, acoustic echoes picked up by multiple microphones make the real-time application very difficult to implement. In this paper, a new approach to these problems is proposed. This new acoustic echo cancellation microphone system consists of two closely positioned directional microphones pointed in opposite directions and an adaptive filter. The adaptive filter converges to the transfer function difference between the two echo paths, which are similar since the two microphones are close to each other and far away from the loudspeaker. Therefore, a very-low-order adaptive filter is sufficient to reduce the echo. The steady-state analysis of this new system shows significant improvement over the traditional system. The system is tested using real speech data collected from a typical conference room. The experimental and simulation results show that more than 26 dB of cancellation can be achieved during the receive mode with the filter order equal to 64.
The promise of downlink MU-MIMO for high-capacity next generation mobile broadband networks based on IEEE 802.16 m (2011)

The dramatic increase of the demand for mobile broadband services poses stringent requirements on the performance evolution of currently deployed mobile broadband networks, such as Mobile WiMAX Release 1 and 3GPP LTE Release 8. Although the combination of single-user multiple-input multiple-output (SU-MIMO) and orthogonal frequency division multiple access (OFDMA) provide the appropriate technologies for improving the downlink performance of third generation (3G) code division multiple access (CDMA)-based mobile radio systems and, thus, address the current mobile internet requirements, a fundamental paradigm shift is required to cope with the constantly increasing mobile broadband data rate and spectral efficiency requirements. Among the different technologies available for making the paradigm shift from current to next-generation mobile broadband networks, multiuser MIMO (MU-MIMO) constitutes the most promising technology because of its significant performance improvement advantages. In this article, we analyze the performance of MU-MIMO under a multitude of deployment scenarios and system parameters through extensive system-level simulations which are based on widely used system-level evaluation methodologies. The target mobile broadband system used in the simulations is IEEE 802.16 m which was recently adopted by ITU-R as an IMT-Advanced technology along with 3GPP LTE-Advanced. The results provide insights into different aspects of MU-MIMO with respect to system-level performance, parameter sensitivity, and deployment scenarios, and they can be used by the mobile broadband network designer for maximizing the benefits of MU-MIMO in a scenario with specific deployment requirements and goals.
An Equivalent Circuit Model for Nested Split-Ring Resonators (2017)

In this paper, an equivalent circuit model for nested split-ring resonators (NSRRs) is proposed. NSRRs are an emerging class of split ring resonators, preferred in a range of areas from sensing in biomedical or civil engineering applications to antenna design, due to their more compact size and enhanced sensitivity/resolution characteristics over the conventional SRRs. In the proposed model, the NSRR structure is treated as a combination of basic elements, i.e., strips and gaps, and the electromagnetic characteristics of the whole geometry are expressed in terms of capacitances and inductances of each of these elements. The outputs of the model are compared with those obtained via full-wave simulations using the package programs as well as measurements. The variation of NSRR resonance frequency (f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">res</sub> ) with all important design parameters is also compared with full-wave simulations. In all comparisons, the results demonstrate agreement, showing that the proposed model can correctly explain the electromagnetics of the NSRR structure and that it provides an intuitive way for a better and easier analysis and a preliminary design of normally complex structures.
DNA Electrophoresis on a Flat Surface (2000)

We report a new approach for performing DNA electrophoresis. Using experimental studies and molecular dynamics simulations, we show that a perfectly flat silicon wafer, without any surface features, can be used to fractionate DNA in free solution. We determine that the ability of a flat surface to separate DNA molecules results from the local friction between the surface and the adsorbed DNA segments. We control this friction by coating the Si surface with silane monolayer films and show that it is possible to systematically change the size range of DNA that can be separated.
Haematopoietic stem cell transplantation for treatment of primary CNS lymphoma: single‐centre experience and literature review (2014)

Primary central nervous system lymphoma (PCNSL) is a rare and malignant tumour type. Established treatment approaches include high-dose methotrexate (HD-MTX)-based chemotherapy and whole-brain radiotherapy (WBRT). WBRT is associated with significant neurotoxicity and autologous haematopoietic stem cell transplantation (ASCT) has been proposed as an alternative treatment - either in the 1st line setting after HD-MTX-based chemotherapy or as salvage treatment for relapsed/refractory PCNSL. We here report our single-centre experience with five PCNSL patients, who had achieved an objective response after a high-dose methotrexate-based induction therapy and consecutively received a high-dose chemotherapy, consisting of carmustine and thiotepa, followed by ASCT. We also provide a literature review on ASCL for PCNSL. Our data, with three of five patients in continuous complete remission and four of five patients alive after a median follow-up time of 8 months, as well as previously published results, show that ASCT is a safe treatment option that is able to induce tumour remissions in patients with PCNSL. However, controlled trials are needed to compare the long-term efficacy and tolerability of ASCT with other treatment approaches and also to establish the optimal sequence of treatment regimens in PCNSL patients.
Chromatographic and fluorescence spectroscopic studies of individual 7,12-dimethylbenz[a]anthracene – deoxyribonucleoside adducts (1983)

Compared with standard Sephadex LH-20 column chromatography, a newly developed high pressure liquid chromatographic separation of hydrocarbon deoxyribonucleoside adducts derived from the DNA of mouse embryo cell cultures exposed to 7,12-dimethylbenz[a]anthracene (DMBA) provides markedly superior resolution. Once resolved, the fluorescence spectroscopic properties of the three major DMBA--DNA adducts indicate that the fluorescence exhibited by adducts derived from a bay region syn dihydrodiol epoxide of DMBA differs subtly from that exhibited by adducts derived from the isomeric anti dihydrodiol epoxide.