gebhart/patrepeval huggingface dataset:
Program Optimization Study on a 128-Core GPU (2011)

Abstract — The newest generations of graphics processing unit (GPU) architecture, such as the NVIDIA GeForce 8-series, feature new interfaces that improve programmability and generality over previous GPU generations. Using NVIDIA’s Compute Unified Device Architecture (CUDA), the GPU is presented to developers as a flexible parallel architecture. This flexibility introduces the opportunity to perform a wide variety of parallelization optimizations on applications, but it can be difficult to choose and control optimizations to give reliable performance benefit. This work presents a study that examines a broad space of optimization combinations performed on several applications ported to the GeForce 8800 GTX. By doing an exhaustive search of the optimization space, we find configurations that are up to 74 % faster than those previously thought optimal. We explain the effects that optimizations can have on this architecture and how they differ from those on more traditional processors. For some optimizations, small changes in resource usage per thread can have very significant performance ramifications due to the thread assignment granularity of the platform and the lack of control over scheduling and allocation behavior of the runtime. We conclude with suggestions for better controlling resource usage and performance on this platform. I.
An empirical evaluation of user interfaces for topic management of Web sites (1999)

Topic management is the task of gathering, evaluating, organizing, and sharing a set of web sites for a specific topic. Current web tools do not provide adequate support for this task. We created the TopicShop system to address this need. TopicShop includes (1) a webcrawler that discovers relevant web sites and builds site profiles, and (2) user interfaces for exploring and organizing sites. We conducted an empirical study comparing user performance with TopicShop vs. YahooTM. TopicShop subjects found over 80% more high-quality sites (where quality was determined by independent expert judgements) while browsing only 8 1% as many sites and completing their task in 89% of the time. The site profile data that TopicShop provides - in particular, the number of pages on a site and the number of other sites that link to it - was the key to these results, as users exploited it to identify the most promising sites quickly and easily.
Dimsyl Anion Induced Demethylation and Fragmentation Reactions of α‐Oxoketenedithioacetals. (2001)

Abstract For Abstract see ChemInform Abstract in Full Text.
Scalable CMOS power devices with 70% PAE and 1, 2 and 3.4 Watt output power at 2GHz (2009)

This paper reports RF power devices achieving 70% power-added efficiency (PAE) with 1, 2 and 3.4 W output power at 2 GHz. The power devices operate as sub-optimum class-E power amplifiers, having the advantage of 1.6 times higher output power with a slightly lower PAE than conventional class-E. The power devices use high voltage extended-drain NMOS (ED-NMOS) transistors in standard 65 nm CMOS. A scalable layout design that we used preserves the high PAE for the various output power levels.
Heat Stability of Sunflower‐Hull Anthocyanin Pigment (1991)

ABSTRACT Anthocyanin pigment was extracted from hulls of a sunflower genotype, Neagra de Cluj, using aqueous SO 2 solutions of varying concentrations. Thermal stability of the pigment was studied between 65–95°C, and pH 1.0–5.0. Thermal degradation of the pigment followed first order kinetics. Calculated activation energy was 23.1 ± 2.2 kcal/ mole. Extraction of hulls with 1000 ppm SO 2 solution gave highest anthocyanin content and best thermal stability. The pigment was most stable at pH 3.0.
Lean Stability Limits and Exhaust Emissions of Ammonia-Methane-Air Swirl Flames at Micro Gas Turbine Relevant Pressure (2022)

Abstract This study reports on the lean stability limits and exhaust emissions of ammonia-methane-air swirl flames with varied ammonia fuel fractions. A reduced-scale burner was manufactured, inspired by Ansaldo’s micro gas turbine AE-T100 burner, and it was installed inside a high-pressure combustion duct to operate at 4.5 bar. This pressure corresponds to that found at full-load in the actual micro gas turbine’s combustion chamber. The lean stability limits were measured by igniting the flame at an equivalence ratio of ϕ = 0.85 and then progressively decreasing the equivalence ratio until lean blowout. Emissions of CO2, NO, and N2O were recorded for different equivalence ratios and ammonia fractions. Rich flames at an equivalence ratio of ϕ = 1.20 were also considered. Results show that the equivalence ratio at lean blowout increases when the ammonia fraction increases and that all the ammonia fractions tested lead to flames more prone to lean blowout than the pure methane reference flame. The CO2 emissions are monotonically reduced by increasing the ammonia fraction, both for lean and rich flames. The NO emissions exceed many regulations limit regardless of the ammonia fraction for all lean equivalence ratios. N2O emissions are almost negligible, except for very lean equivalence ratios where the N2O mole fraction in the exhaust reaches unacceptably high values. Only rich ammonia-methane-air flames show good NO and N2O performance. Therefore, FTIR analysis was carried out to quantify the amount of the unburnt NH3 in the exhaust for these flames. Results show that unburnt NH3 concentration is invariant, around 200 ppmv, between 0.70 ≤ XNH3 ≤ 0.95. Data reported in this study provide insights for future work on combustors and after-treatment systems towards zero-emissions micro gas turbines.
Oxygen-binding to a lipophilic diporphinato copper–iron complex in an aqueous medium (1985)

A tetradecyl-substituted diporphinato copper–iron complex, (1a), was synthesized and solubilized in an aqueous medium with a surfactant; the oxygen and carbon monoxide binding affinity and the binding rate constants were measured.
Effects of Growth Hormone Overexpression and Growth Hormone Resistance on Neuroendocrine and Reproductive Functions in Transgenic and Knock‐Out Mice2 (1999)

Transgenic mice overexpressing growth hormone (GH) exhibit alterations in the function of the hypothalamic-pituitary-gonadal (HPG) axis and the H-P-adrenal axis. Alterations in the turnover of hypothalamic neurotransmitters, in plasma hormone levels, and in regulation of their release are associated with reproductive deficits, particularly in females. Results reported after publication of our minireview on this subject provided evidence that GH-transgenic mice have increased binding of GH to GH binding proteins in plasma, are hyperinsulinemic and insulin resistant, and have major alterations in energy budgets with increased allocation to growth. Reduced life span and fertility of these animals may be related to insufficient allocation of energy to reproduction and maintenance. Growth hormone resistance induced by transgenic expression of an antagonistic bGH analog or by targeted disruption (knock-out, KO) of the GH receptor (GH-R) gene leads to dramatic suppression of plasma levels of insulin-like growth factor-1 (IGF-1), and dwarf phenotype due to reduced growth and increased adiposity. In both models of GH resistance, there are marked reproductive deficits in females, decline of breeding performance of males, and alterations in the function of the HPG axis. In GH-R-KO females, puberty is delayed, and litter size is reduced. Fetal weights are reduced whereas placental weights are increased, and the weight of newborn pups is reduced despite an increase in the length of gestation. In GH-R-KO males, copulatory behavior and fertility are reduced, plasma PRL is elevated, and responses to luteinizing hormone releasing hormone (LHRH) in vivo and to LH in vitro are suppressed. However, reproductive deficits in GH-R-KO mice are very mild when compared to those described previously in IGF-KO animals. Apparently, the amounts of IGF-1 that may be produced locally in the absence of GH stimulation are sufficient for sexual maturation and fertility in both sexes, whereas quantitative deficits in reproductive function reflect absence of GH-dependent IGF-1 production and other consequences of eliminating GH signaling. The reproduction phenotype of the GH-R-KO mice is also mild when compared to dwarf mice that lack GH, prolactin (PRL), and thyroid stimulating hormone (TSH). This is presumably related to the presence of redundant mechanisms in the stimulatory control of the gonads by the pituitary and the ability of animals capable of producing PRL and TSH to compensate partially for the absence of GH signaling.
Conducting Polymer Transistors Making Use of Activated Carbon Gate Electrodes (2014)

The characteristics of the gate electrode have significant effects on the behavior of organic electrochemical transistors (OECTs), which are intensively investigated for applications in the booming field of organic bioelectronics. In this work, high specific surface area activated carbon (AC) was used as gate electrode material in OECTs based on the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) doped with poly(styrenesulfonate) (PSS). We found that the high specific capacitance of the AC gate electrodes leads to high drain-source current modulation in OECTs, while their intrinsic quasi-reference characteristics make unnecessary the presence of an additional reference electrode to monitor the OECT channel potential.
Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic (2019)

Abstract Understanding how genes and experiences work in concert to generate phenotypic variability will provide a better understanding of individuality. Here, we considered this in the context of the main olfactory epithelium, a chemosensory structure with over a thousand distinct cell-types, in mice. We identified a subpopulation of at least three types of olfactory sensory neurons, defined by receptor expression, whose abundances were sexually dimorphic. This subpopulation of olfactory sensory neurons was over-represented in sex-separated female mice and responded robustly to the male-specific semiochemicals 2- sec -butyl-4,5-dihydrothaizole and (methylthio)methanethiol. Sex-combined housing led to a robust attenuation of the female over-representation. Testing of Bax null mice revealed a Bax -dependence in generating the sexual dimorphism in sex-separated mice. Altogether, our results suggest a profound role of experience in influencing homeostatic neural lifespan mechanisms to generate a robust sexually dimorphic phenotype in the main olfactory epithelium.
Tutorials - HOTI 2012 (2012)

This keynotes discusses the following: Hands-on Tutorial on Software-Defined Networking; Interconnection Networks for Cloud Data Centers; Designing Scientific, Enterprise, and Cloud Computing Systems with InfiniBand and High-Speed Ethernet: Current Status and Trends; The Evolution of Network Architecture towards CloudCentric Applications.
Loop-mediated isothermal amplification (LAMP) assay for specific and rapid detection of Dickeya fangzhongdai targeting a unique genomic region (2022)

Abstract Dickeya fangzhongdai , a bacterial pathogen of taro ( Colocasia esculenta ), onion ( Allium sp.), and several species in the orchid family ( Orchidaceae ), causing soft rot and bleeding canker diseases. No field-deployable diagnostic tool is available for specific detection of this pathogen in different plant tissues. Therefore, we developed a field-deployable loop-mediated isothermal amplification (LAMP) assay using a unique genomic region, present exclusively in D. fangzhongdai . Multiple genomes of D. fangzhongdai , and other species of Dickeya , Pectobacterium and unrelated genera were used for comparative genomic analyses to identify an exclusive and conserved target sequence from the major facilitator superfamily (MFS) transporter gene region. This gene region had broad detection capability for D. fangzhongdai and thus was used to design primers for endpoint PCR and LAMP assays. In-silico validation showed high specificity with D. fangzhongdai genome sequences available in the NCBI GenBank genome database as well as the in-house sequenced genome. The specificity of the LAMP assay was determined with 96 strains that included all Dickeya species and Pectobacterium species as well as other closely related genera, and 5 hosts; no false positives or false negatives were detected. The detection limit of the assay was determined by performing four sensitivity assays with 10-fold serially diluted purified genomic DNA of D. fangzhongdai with and without the presence of crude host extract (taro, orchid, and onion). The detection limit for all sensitivity assays was 100 fg (18–20 genome copies) with no negative interference by host crude extracts. The assays were performed by five independent operators (blind test) and on three instruments (Rotor-Gene, thermocycler and dry bath); the assay results were concordant. The assay consistently detected the target pathogen from artificially inoculated and naturally infected host samples. The developed assay is highly specific for D. fangzhongdai and has applications in routine diagnostics, phytosanitary and seed certification programs, and epidemiological studies.
Applications of Baylis—Hillman Acetates: One‐Pot, Facile and Convenient Synthesis of Substituted γ‐Lactams. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Effect of Refractive Solid Immersion Lens parameters on the enhancement of laser induced fault localization techniques (2008)

The effect of Refractive Solid Immersion Lens (RSIL) parameters on the enhancement to laser induced fault localization techniques are investigated. The experimental results of the effect on a common laser induced technique, namely Thermally Induced Voltage Alteration (TIVA), and imaging are presented. A signal enhancement in the peak TIVA signal of close to 12 times has been achieved.
Thyroid Abnormalities in Peutz-Jeghers Syndrome: Report of a New Observation and Review of the Literature (1999)

Article Thyroid Abnormalities in Peutz-Jeghers Syndrome: Report of a New Observation and Review of the Literature was published on January 1, 1999 in the journal International Journal on Disability and Human Development (volume 1, issue 1).
Evaluation of the effect of d-amino acid incorporation into amyloid-reactive peptides (2017)

Incorporation of D-amino acids in amyloid-binding regions of amyloidophilic peptides resulted in off-target binding; however, N-terminus placement retained amyloid-specificity and evasion of deiodinases. Peptide <sup>aqa</sup>p5, or similar reagents, may prove useful in novel immunotherapy strategies as well as for imaging renal, gastric and pancreatic amyloidosis.
Partial discharge characteristics in motor insulations under exposure to multi-level inverters (2017)

The use of variable speed drives fed by pulse width modulated (PWM) inverters allows a more efficient use of electric energy. The drawback is however that the stress imposed on motor winding insulation increases and partial discharges (PDs) appear under such conditions, being considered the major contributor to the reduction in the insulation life time. We present in this paper changes observed in the PD characteristics of motor insulation systems aimed for different voltage levels. These were a twisted pair test object as well as a higher voltage level motor insulation wire, fed from either two- or three-level inverters. Each of the objects was subjected to PWM waveforms of different rise-times. The twisted pair test objects were insulated by a chromium oxide filled enamel, whereas the motor insulation objects were micaepoxy based. To compare the performances, measurements of extinction voltages and PD characteristics were conducted. Specifically, the total number of PDs and their amplitude per cycle were obtained at 2.5 and 4.5 kV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> , dependent on the system tested. The experimental results showed that the total summed PD magnitude drops considerably when applying a three level inverter. However the maximum PD magnitude remain at the same level for the same rise time in both cases. Also the extinction voltage remains the same for a specific rise time. The PD magnitude decreases for increased rise time, similarly for both the cases. Thus the presented observations suggest that a change to a multilevel inverter alone may not be sufficient for increasing the motor insulation system life.
Display of Multimeric Antimicrobial Peptides on the Escherichia coli Cell Surface and Its Application as Whole-Cell Antibiotics (2013)

Concerns over the increasing emergence of antibiotic-resistant pathogenic microorganisms due to the overuse of antibiotics and the lack of effective antibiotics for livestock have prompted efforts to develop alternatives to conventional antibiotics. Antimicrobial peptides (AMPs) with a broad-spectrum activity and rapid killing, along with little opportunity for the development of resistance, represent one of the promising novel alternatives. Their high production cost and cytotoxicity, however, limit the use of AMPs as effective antibiotic agents to livestock. To overcome these problems, we developed potent antimicrobial Escherichia coli displaying multimeric AMPs on the cell surface so that the AMP multimers can be converted into active AMP monomers by the pepsin in the stomach of livestock. Buf IIIb, a strong AMP without cytotoxicity, was expressed on the surface of E. coli as Lpp-OmpA-fused tandem multimers with a pepsin substrate residue, leucine, at the C-terminus of each monomer. The AMP multimers were successfully converted into active AMPs upon pepsin cleavage, and the liberated Buf IIIb-L monomers inhibited the growth of two major oral infectious pathogens of livestock, Salmonella enteritidis and Listeria monocytogenes. Live antimicrobial microorganisms developed in this study may represent the most effective means of providing potent AMPs to livestock, and have a great impact on controlling over pathogenic microorganisms in the livestock production.
Control of Complex Multibody Spacecraft (1989)

Abstract : The Project C-MULTICS (Control of Complex Multibody Spacecraft) is a center of excellence at the University of Maryland. The work supported by this project is concerned with the modeling, analysis, control and simulation of large scale complex multibody spacecraft with rigid and flexible components. Keywords: Analytic mechanics; Nonlinear/distributed control; Flexible structures; Spacecraft components rigidity.
Phenylpiperazinylalkylamino Substituted Pyridazinones as Potent α1 Adrenoceptor Antagonists (2001)

QSAR models have been used for designing a series of compounds characterized by a N-phenylpiperazinylalkylamino moiety linked to substituted pyridazinones, which have been synthesized. Measurements of the binding affinities of the new compounds toward the alpha(1a)-, alpha(1b)-, and alpha(1d)-AR cloned subtypes as well as the 5-HT(1A) receptor have been done validating, at least in part, the estimations of the theoretical models. This study provides insight into the structure activity relationships of the alpha(1)-ARs ligands and their alpha(1)-AR/5-HT(1A) selectivity.
A Fast Frequency Control Strategy for Deloaded WTG in the Power System with High Penetration of Renewable Energy (2019)

With the increasing penetration of wind power, the capability of the power system to maintain frequency stability decreases. Therefore, frequency support for grid from wind turbine generators (WTGs) are required. WTGs usually operate without reserve power and can only provide short-term frequency support by utilizing the rotational kinetic energy. While, the deloaded WTG has a certain power reserve, which can be utilized during frequency control. This paper presents a fast frequency control strategy for the deloaded WTG, which not only imitates the primary frequency regulation characteristic of synchronous generators, but also utilizes the fast power adjustment capability of WTGs to increase the output power a lot at the early stage to reduce the rate of change of frequency. The frequency controller parameters and deload level of WTG are also carefully designed. The simulation results demonstrate that the control method can significantly enhance the system frequency control effect.
Wet Chemical Processing of Ge in Acidic H 2 O 2 Solution: Nanoscale Etching and Surface Chemistry (2020)

Herein, we investigate wet-chemical etching of Ge (100) in acidic H 2 O 2 solutions for technologically advanced device processing. Nanoscale etching kinetics data were provided by inductively coupled plasma mass spectrometry (ICP-MS) measurements. Rotation rate- dependent measurement showed that the hydrodynamics of the system is important. The dependence of the etch rate on the HCl concentration was considered for the range 0.001–1 M HCl. A stark difference morphologically for &gt;1 M HCl, which resulted in a rough surface confirmed by atomic force microscopy (AFM) images, has been observed. X-ray photoelectron spectroscopy (XPS) measurements provided insight in the surface chemistry of etching for device processing. Electrochemical measurements confirmed that the etching process follows a chemical mechanism. Based on X-ray photoelectron spectroscopy (XPS) data, we present reaction schemes that help to understand the results.
Clinical Outcome and Pharmacokinetics After Addition of Low-Dose Cyclosporine to Methotrexate: A Case Study of Five Patients with Treatment-Resistant Inflammatory Bowel Disease (2000)

This study reports the clinical outcome, toxicity, and methotrexate pharmacokinetics after the addition of low-dose cyclosporine to methotrexate in patients with ulcerative colitis or Crohn's disease. Three patients with steroid-refractory ulcerative colitis and two patients with steroid refractory Crohn's disease who failed monotherapy with subcutaneous methotrexate 25 mg/week for 16 weeks were treated with the combination of methotrexate and low-dose oral cyclosporine (3 mg/kg/day) for an additional 16 weeks. Clinical response was measured with the Inflammatory Bowel Disease Questionnaire (IBDQ) score. Concentrations of erythrocyte methotrexate, plasma methotrexate, and plasma 7-hydroxymethotrexate were also determined. Both patients with Crohn's disease withdrew from the study for toxicity (headaches, seizure). The three patients with ulcerative colitis experienced clinical improvement with a mean increase in the IBDQ score from 164 to 190 points, p = 0.01. The mean serum creatinine in the three patients who completed the study increased from 0.9 mg/dL at baseline to 1.2 mg/dL at week 16, p = 0.04. One patient developed hypertension. There was no significant change from baseline in the concentrations of erythrocyte methotrexate, plasma methotrexate, and plasma 7-hy-droxymethotrexate. Combination therapy with methotrexate and low-dose oral cyclosporine did not alter methotrexate pharmacokinetics and resulted in high rates of cyclosporine-associated toxicity.
Correction: Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency (2019)

[This corrects the article DOI: 10.18632/oncotarget.14540.].