gebhart/patrepeval huggingface dataset:
The Combechem MQTT LEGO microscope: a grid enabled scientific apparatus demonstrator (2006)

Grid computing impacts directly on the experimental scientific laboratory in the areas of monitoring and remote control of experiments, and the storage, processing and dissemination of the resulting data. \nWe highlight some of the issues in extending the use of an MQ Telemetry Transport (MQTT) broker from facilitating the remote monitoring of an experiment and its environment to the remote control of an apparatus.\nTo demonstrate these techniques, an Intel-Play QX3 microscope has been "grid-enabled" using a combination of software to control the microscope imaging, and sample handling hardware built from LEGO Mindstorms. The whole system is controlled remotely by passing messages using an IBM WebSphere Message Broker. &lt;br/&gt;
Mycobacterium tuberculosis chaperonin 10 and N‐truncated fragments Their synthesis and purification by the isoelectric focusing technique carried out in solution (1997)

The Mycobacterium tuberculosis chaperonin 10 protein and fragments corresponding to sequences 59-99, 51-99 and 26-99 were synthesised by the solid-phase methodology using a double coupling protocol and without the aid of capping agents. After the final acid cleavage using the low TFMSA-high HF protocol the polypeptides were purified by either the ion exchange chromatography/RP-HPLC combination or the isoelectric separation carried out in solution and followed by semi-preparative RP-HPLC. Comparison of the results obtained through the two approaches indicated that in general the isoelectricfocusing/HPLC combination was superior both in terms of recovery of final material and its purity. The advantages found were as follows: (i) Unlike ion exchange chromatography, no tailoring of the separation conditions is required, (ii) Several consecutive focusings can be carried out in progressively narrower pH gradients. This increases the separation resolution without the need of changing other separation parameters, (iii) Very little manipulation is needed, and each focusing requires 3-5h. (iv) Full compatibility with non-ionic denaturants such as 8 M urea. This increases solubility so that using the ROTOFOR instrument described here 50-100 mg crude polypeptide can be processed daily. Thus the isoelectric focusing technique carried out in solution is a valid and inexpensive alternative to ion exchange chromatography.
Intra- and intermolecular organoactinide carbon-hydrogen activation pathways. Formation, properties, and reactions of thoracyclobutanes (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntra- and intermolecular organoactinide carbon-hydrogen activation pathways. Formation, properties, and reactions of thoracyclobutanesJoseph W. Bruno, Tobin J. Marks, and Victor W. DayCite this: J. Am. Chem. Soc. 1982, 104, 25, 7357–7360Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/ja00389a096https://doi.org/10.1021/ja00389a096research-articleACS PublicationsRequest reuse permissionsArticle Views237Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Enhanced Coercivity in Co‐Rich Near‐Stoichiometric CoxFe3‐xO4+δ Nanoparticles Prepared in Large Batches. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Surface Response Methodology for Write Strategy Optimisation in Optical Drives (2004)

A method for optimising write strategies in optical drives is proposed which is rigid and gives additional information on the reliability of the calculated results. In addition, the mathematical tool is used to examine the typical differences in write strategies with respect to parameter variations. As a test platform, digital versatile discs of the recordable type (DVD+R) are used at a speed of 8×. A comparison is made between the “castle” strategy and the blocked “thermally balanced” strategy. The differences are verified on three different discs. It appears that the write strategy determines the interdependence between write strategy parameters, while the disc brands differ in the optimum settings of the parameter. The presented method and experiments once more show the power of mathematical tools for understanding and applying physical processes.
Glucose‐lowering treatment pathways of individuals with chronic kidney disease and type 2 diabetes according to the Kidney Disease: Improving Global Outcomes 2012 risk classification (2023)

Individuals with CKD and T2D had many combinations of therapies and substantial follow-up time on therapy. These results highlight opportunities for improved CKD management.
The Effect of Inlet Boundary Layer Thickness on the Flow Within an Annular S-Shaped Duct (1998)

Experimental and numerical investigations were carried out to gain a better understanding of the flow characteristics within an annular S-shaped duct, including the effect of the inlet boundary layer (IBL) on the flow. A duct with six struts and the same geometry as that used to connect compressor spools on our experimental small two-spool turbofan engine was investigated. A curved downstream annular passage with a similar meridional flow path geometry to that of the centrifugal compressor has been fitted at the exit of S-shaped duct. Two types of the IBL (i.e. thin and thick IBL) were used. Results showed that large differences of flow pattern were observed at the S-Shaped duct exit between two types of the IBL, though the value of “net” total pressure loss has not been remarkably changed. According to “overall” total pressure loss, which includes the IBL loss, the total pressure loss was greatly increased near the hub as compared to that for a thin one. For the thick IBL, a vortex pair related to the hub-side horseshoe vortex and the separated flow found at the strut trailing edge has been clearly captured in the form of the total pressure loss contours and secondary flow vectors, experimentally and numerically. The high-pressure loss regions on either side of the strut wake near the hub may act on a downstream compressor as a large inlet distortion, and strongly affect the downstream compressor performance. There is a much-distorted three-dimensional flow pattern at the exit of S-Shaped duct. This means that the aerodynamic sensitivity of S-Shaped duct to the IBL thickness is very high. Therefore, sufficient carefulness is needed to design not only downstream aerodynamic component (for example centrifugal impeller) but also upstream aerodynamic component (LPC OGV).
OCT-based arterial elastography: robust estimation exploiting tissue biomechanics (2004)

We present a novel multi-resolution variational framework for vascular optical coherence elastography (OCE). This method exploits prior information about arterial wall biomechanics to produce robust estimates of tissue velocity and strain, reducing the sensitivity of conventional tracking methods to both noise- and strain-induced signal decorrelation. The velocity and strain estimation performance of this new estimator is demonstrated in simulated OCT image sequences and in benchtop OCT scanning of a vascular tissue sample.
Interferometric time measurements of intermodal dispersion in optical fibers by using a CCD photodetector array (1992)

An interferometric time measurement of the intermodal dispersion in a 40-m telecommunication fiber at 560 nm is reported. Six modes are identified as LP modes by their spatial interference pattern and are clearly time resolved. To overcome laser noise and low interference contrast, a new interferometric time measurement technique has been developed. The image of the interference fringe pattern is analyzed by a CCD photodetector array. Interference fringes produce a modulation at the CCD's output that can be filtered and averaged to retrieve accurate time information.
Generalized Approximate Message Passing for Cosparse Analysis Compressive Sensing (2013)

In cosparse analysis compressive sensing (CS), one seeks to estimate a non-sparse signal vector from noisy sub-Nyquist linear measurements by exploiting the knowledge that a given linear transform of the signal is cosparse, i.e., has sufficiently many zeros. We propose a novel approach to cosparse analysis CS based on the generalized approximate message passing (GAMP) algorithm. Unlike other AMP-based approaches to this problem, ours works with a wide range of analysis operators and regularizers. In addition, we propose a novel $\ell_0$-like soft-thresholder based on MMSE denoising for a spike-and-slab distribution with an infinite-variance slab. Numerical demonstrations on synthetic and practical datasets demonstrate advantages over existing AMP-based, greedy, and reweighted-$\ell_1$ approaches.
Using the approach of step-by-step lithological dissection of the section of volcanogenic sedimentary deposits (2022)

The article implements an approach of step-by-step lithological dissection of the section of volcanogenic sedimentary rocks of the Sredne-Nazymskoye field using comparisons of methods of geophysical surveys of rocks at the qualitative and quantitative level.The predominantly acidic composition of the rocks determines the use of unified petrophysical algorithms for the section of the Pre-Jurassic complex with additional division into enlarged groups of lithotypes: lavobreccia, tuffs and unchanged effusions. An important factor influencing the interpretation of geophysical surveys is the presence of rock fracturing in the Pre-Jurassic complex interval.The assessment of the possibility of lithological dissection of the section, taking into account the additional division of rocks into collector-non-collector, which allows us to identify promising zones of development of pore and fractured reservoirs.We propose an approach of step-by-step lithological dissection of the section, including qualitative and quantitative criteria, which ensures the improvement of existing technologies.
Design and Characterization of Inductors for Self-Powered IoT Edge Devices (2018)

This paper discusses the design, fabrication, and characterization of packaged planar inductors with magnetic material [nickel zinc (NiZn) ferrite]. Inductors are designed specifically for Internet of Things (IoT) applications based on power loss in an IoT architecture. Different spiral inductor geometries are demonstrated on a printed wiring board with varying thicknesses using a stencil printing process. The magnetic material can be applied to one or both sides of the inductor and, therefore, provides size reduction. This paper examines the role of varying dimensions on inductor performance along with model-to-hardware correlation. The fabrication process demonstrates inductance increase through a very simple procedure for applying a magnetic material on both sides of the inductor, while having flexibility to customize the geometry for minimal power loss in an IoT architecture. With NiZn ferrite material added to both sides of the inductor, the inductance increases between approximately 60% and 80% for the two substrate thicknesses studied, as compared to air-core inductors.
Type II toxin/antitoxin MqsR / MqsA controls type V toxin/antitoxin GhoT / GhoS (2012)

Toxin endoribonucleases of toxin/antitoxin (TA) systems regulate protein production by selectively degrading mRNAs but have never been shown to control other TA systems. Here we demonstrate that toxin MqsR of the MqsR/MqsA system enriches toxin ghoT mRNA in vivo and in vitro, since this transcript lacks the primary MqsR cleavage site 5'-GCU. GhoT is a membrane toxin that causes the ghost cell phenotype, and is part of a type V TA system with antitoxin GhoS that cleaves specifically ghoT mRNA. Introduction of MqsR primary 5'-GCU cleavage sites into ghoT mRNA reduces ghost cell production and cell death likely due to increased degradation of the altered ghoT mRNA by MqsR. GhoT also prevents cell elongation upon the addition of low levels of ampicillin. Therefore, during stress, antitoxin GhoS mRNA is degraded by toxin MqsR allowing ghoT mRNA translation to yield another free toxin that forms ghost cells and increases persistence. Hence, we show that GhoT/GhoS is the first TA system regulated by another TA system.
Phenogenomic heterogeneity of post-transplant plasmablastic lymphomas (2020)

Plasmablastic lymphoma (PBL) is a rare and clinically aggressive neoplasm that typically occurs in immunocompromised individuals, including those with HIV infection and solid organ allograft recipients. Most prior studies have focused on delineating the clinicopathologic features and genetic attributes of HIV-related PBLs, where MYC deregulation and EBV infection, and more recently, mutations in JAK/STAT, MAP kinase, and NOTCH pathway genes have been implicated in disease pathogenesis. The phenotypic spectrum of post-transplant (PT)-PBLs is not well characterized and data on underlying genetic alterations are limited. Hence, we performed comprehensive histopathologic and immunophenotypic evaluation and targeted sequencing of 18 samples from 11 patients (8 males, 3 females, age range 12-76 years) with PT-PBL; 8 de novo and 3 preceded by other types of PTLDs. PT-PBLs displayed morphologic and immunophenotypic heterogeneity and some features overlapped those of plasmablastic myeloma. Six (55%) cases were EBV+ and 5 (45%) showed MYC rearrangement by fluorescence in situ hybridization. Recurrent mutations in epigenetic regulators (KMT2/MLL family, TET2) and DNA damage repair and response (TP53, mismatch repair genes, FANCA, ATRX), MAP kinase (KRAS, NRAS, HRAS, BRAF), JAK/STAT (STAT3, STAT6, SOCS1), NOTCH (NOTCH1, NOTCH3, SPEN), and immune surveillance (FAS, CD58) pathway genes were observed, with EBV+ and EBV- cases exhibiting similarities and differences in their mutational profiles. Clinical outcomes also varied, with survival ranging from 0-15.9 years postdiagnosis. Besides uncovering the biological heterogeneity of PT-PBL, our study highlights similarities and distinctions between PT-PBLs and PBLs occurring in other settings and reveals potentially targetable oncogenic pathways in disease subsets.
Status of NIF laser and high power laser research at LLNL (2017)

This talk will provide an overview of high power laser research at Lawrence Livermore National Laboratory (LLNL). It will discuss the status of the National Ignition Facility (NIF) laser. In addition, the talk will describe other laser development activities such as the development of high average power lasers and novel fiber lasers. The National Ignition Facility (NIF) has been in service since 2007 and operating with &gt; 1 MJ energies since 2009. During this time the facility has transitioned to become an international user facility and increased the shot rate from ~150 target shots per year to greater than 400 shots per year. Today, the NIF plays an essential role in the US Stockpile Stewardship Program, providing data under the extreme conditions needed to validate computer models and train the next generation of stockpile stewards. Recent upgrades include the Advanced Radiographic Capability (ARC), a high energy short pulse laser used to do high resolution radiography. In addition to the NIF, this talk will include an overview of progress on the high average power laser development, recent results from fiber laser development activities and improvements to laser design and computational capabilities.
On user interactions with query auto-completion (2014)

Query Auto-Completion (QAC) is a popular feature of web search engines that aims to assist users to formulate queries faster and avoid spelling mistakes by presenting them with possible completions as soon as they start typing. However, despite the wide adoption of auto-completion in search systems, there is little published on how users interact with such services.
Involvement of caspases in sympathetic neuron apoptosis (1997)

In order to study the involvement of caspases in neuronal cell death, we have examined the effects of the viral caspase inhibitor p35 and peptide caspase inhibitors on sympathetic neurons isolated from the superior cervical ganglion (SCG). In these neurons, apoptosis can be induced by the withdrawal of nerve growth factor (NGF) and also by the addition of the kinase inhibitor staurosporine. p35 has been shown to be a broad spectrum inhibitor of the caspase family and promotes the survival of SCG neurons withdrawn from NGF. We show that p35 is also protective when apoptosis is induced by staurosporine. In addition, p35 inhibits a number of the morphological features associated with apoptosis, such as nuclear condensation, TUNEL labelling, and externalisation of phosphatidylserine. The tri-peptide caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp (O-methyl)-fluoromethylketone (zVAD-fmk) was effective at inhibiting NGF withdrawal-induced and staurosporine-induced apoptosis of SCG neurons. Two other peptide inhibitors, acetyl-Tyr-Val-Ala-Asp-aldehyde (Ac-YVAD-CHO) and acetyl-Asp-Glu-Ala-Asp-aldehyde (Ac-DEVD-CHO), also inhibited apoptosis induced by both means when microinjected into SCG neurons but peptides derived from the caspase cleavage site in p35 were not protective. We present data to suggest that apoptosis induced by separate death stimuli can result either in the activation of distinct caspases or in differences in the time of activation of the family members.
Freedom and the Inescapable Future (2013)

Kazuo Ishiguro's novel Never Let Me Go involves a termporal experiment concerned with reconciling an unexpected revelation with the themes of freedom and fate. This chapter shows that the control of perspective in a first person narration is also a structure that binds together anticipation in memory in a tight complementarity. The analysis shows that the dynamics of prospect and retrospect in this novel demonstrate something about temporal experience in life, the way that it tempers our freedom and reconciles us to unacceptable conditions. The chapter makes use of a sociological concept known as ‘relative deprivation’ to show that narrative temporality can function both as a form of social control and as a defamiliarization of socialization processes. It also argues that the connection between freedom and fate in novelistic structure tends to re-enact at a thematic level the basic conditions of a future that is already in place that applies to all written narrative.
Single dopant atom lithography for the fabrication of quantum computers and low power electronic devices (2021)

In this paper, we describe approaches for the fabrication of single atom devices and spin-based qubits for quantum computing. Addressing of single dopant atoms has the potential to enable precise tunable control over all key electronic properties of basic devices needed for solid-state quantum computing. A new challenge which arises for a variety of qubits is the ability to locate deterministically individual atoms below the surface of the three-dimensional structure to build single or few-atom atom transistors single electron transistors, or diverse quantum sensing devices. Comprehensive applications can be considered for complex donor/acceptor arrangements and this kind of dopant engineering technique has the character of a lithographic method. Scanning Probe Methods are used not only for surface analysis and nanofabrication. We demonstrated in 2004 an integration of a scanning probe with an ion beam similar to the use of a “high resolution dynamic nano-stencil” which enabled the nondestructive imaging of a target together with alignment of an ion beam to device features with a few nanometer accuracy.
Use of the method of moments for analysis of antennas composed of conducting wires and plates (1997)

When the characteristics of antennas with a junction of conducting wires and plates, such as antennas used for portable telephones, are analyzed by the method of moments, a special segment having a wire current and a radial surface current has been used. However, the radius of the radial current of this segment is required to be greater than about 0.2 wavelengths to obtain accurate numerical results. Therefore, this method cannot be applied to antennas having conducting plates whose dimension is less than 0.2 wavelengths. In this paper, another special segment, the “joint patch segment,” which connects the radial segment with the planar segment, is proposed to overcome the limitations of the radial segment. In order to demonstrate the accuracy and the advantages of the proposed method, the frequency characteristics of the input impedance of the planar inverted F antenna mounted on a conducting box are calculated and compared with experimental data. © 1997 Scripta Technica, Inc. Electron Comm Jpn Pt 1, 80(7): 61–69, 1997
Single-cell analysis of the fate of c-kit-positive bone marrow cells (2017)

The plasticity of c-kit-positive bone marrow cells (c-kit-BMCs) in tissues different from their organ of origin remains unclear. We tested the hypothesis that c-kit-BMCs are functionally heterogeneous and only a subgroup of these cells possesses cardiomyogenic potential. Population-based assays fall short of identifying the properties of individual stem cells, imposing on us the introduction of single cell-based approaches to track the fate of c-kit-BMCs in the injured heart; they included viral gene-tagging, multicolor clonal-marking and transcriptional profiling. Based on these strategies, we report that single mouse c-kit-BMCs expand clonally within the infarcted myocardium and differentiate into specialized cardiac cells. Newly-formed cardiomyocytes, endothelial cells, fibroblasts and c-kit-BMCs showed in their genome common sites of viral integration, providing strong evidence in favor of the plasticity of a subset of BMCs expressing the c-kit receptor. Similarly, individual c-kit-BMCs, which were infected with multicolor reporters and injected in infarcted hearts, formed cardiomyocytes and vascular cells organized in clusters of similarly colored cells. The uniform distribution of fluorescent proteins in groups of specialized cells documented the polyclonal nature of myocardial regeneration. The transcriptional profile of myogenic c-kit-BMCs and whole c-kit-BMCs was defined by RNA sequencing. Genes relevant for engraftment, survival, migration, and differentiation were enriched in myogenic c-kit-BMCs, a cell subtype which could not be assigned to a specific hematopoietic lineage. Collectively, our findings demonstrate that the bone marrow comprises a category of cardiomyogenic, vasculogenic and/or fibrogenic c-kit-positive cells and a category of c-kit-positive cells that retains an undifferentiated state within the damaged heart.