gebhart/patrepeval huggingface dataset:
Design method for a broadband inverted F antenna by parallel resonance mode (2004)

Abstract This paper presents a broadband inverted F antenna realized by adding a wire element and describes a method for its design based on the operating principle. This inverted F antenna has a configuration with a wire element attached at the middle of the wire element already connected at the feed point. Broadband operation is made possible by a new method in which a parallel resonance antenna is combined with the wire inverted F antenna, which is a series resonance antenna. A design method is proposed in which matching at each resonant frequency is independently adjusted by means of these two different resonances. Its effectiveness is demonstrated by experiments and by a simulation by NEC2. © 2004 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 87(11): 11–20, 2004; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/ecja.10215
CodeVIO: Visual-Inertial Odometry with Learned Optimizable Dense Depth (2021)

In this work, we present a lightweight, tightly-coupled deep depth network and visual-inertial odometry (VIO) system, which can provide accurate state estimates and dense depth maps of the immediate surroundings. Leveraging the proposed lightweight Conditional Variational Autoencoder (CVAE) for depth inference and encoding, we provide the network with previously marginalized sparse features from VIO to increase the accuracy of initial depth prediction and generalization capability. The compact representation of dense depth, termed depth code, can be updated jointly with navigation states in a sliding window estimator in order to provide the dense local scene geometry. We additionally propose a novel method to obtain the CVAE’s Jacobian which is shown to be more than an order of magnitude faster than previous works, and we additionally leverage First-Estimate Jacobian (FEJ) to avoid recalculation. As opposed to previous works that rely on completely dense residuals, we propose to only provide sparse measurements to update the depth code and show through careful experimentation that our choice of sparse measurements and FEJs can still significantly improve the estimated depth maps. Our full system also exhibits state-of-the-art pose estimation accuracy, and we show that it can run in real-time with single-thread execution while utilizing GPU acceleration only for the network and code Jacobian.
Evaluation of a Remote Sensor for Mobile Source CO Emissions (1991)

Carbon monoxide (CO) emission measurements of thousands of vehicles per day are possible with a recently evaluated remote sensor developed at the University of Denver. Funded by the Environmental Monitoring Systems Laboratory - Las Vegas (EMSL- LV) Innovative Research Program, the evaluation has demonstrated the comparability of volume concentration measurements made by this method with traditional emission monitoring instrumentation. Measurements are made unobtrusively as vehicles pass through an infrared light beam directed across one traffic lane about 25 centimeters above the pavement. A video camera records the vehicle registration number of each vehicle as its CO emissions are measured so that characteristics of individual vehicles and vehicle fleet categories can be associated with each measurement. Determining appropriate applications and monitoring protocols for this technology is the second phase of this Innovative Research Project. Similar remote sensing technology for monitoring mobile hydrocarbon and nitrogen oxide emissions can be developed to address the urban ozone non-attainment problem.
The Combined Use of Alphavirus Replicons and Pseudoinfectious Particles for the Discovery of Antivirals Derived from Natural Products (2014)

Alphaviruses are a prominent class of reemergent pathogens due to their globally expanding ranges, potential for lethality, and possible use as bioweapons. The absence of effective treatments for alphaviruses highlights the need for innovative strategies to identify antiviral agents. Primary screens that use noninfectious self-replicating RNAs, termed replicons, have been used to identify potential antiviral compounds for alphaviruses. Only inhibitors of viral genome replication, however, will be identified using replicons, which excludes many other druggable steps in the viral life cycle. To address this limitation, we developed a western equine encephalitis virus pseudoinfectious particle system that reproduces several crucial viral life cycle steps in addition to genome replication. We used this system to screen a library containing ~26,000 extracts derived from marine microbes, and we identified multiple bacterial strains that produce compounds with potential antiviral activity. We subsequently used pseudoinfectious particle and replicon assays in parallel to counterscreen candidate extracts, and followed antiviral activity during biochemical fractionation and purification to differentiate between inhibitors of viral entry and genome replication. This novel process led to the isolation of a known alphavirus entry inhibitor, bafilomycin, thereby validating the approach for the screening and identification of potential antiviral compounds.
Pursuing pluripotency (LL2-4) (2010)

Many of the regulatory components responsible for the control of cell fate decisions in embryonic or induced pluripotent stem cells (ESC and iPSC) have been identified. These include a variety of epigenetic, transcriptional and signaling molecules. However, a comprehensive systems level understanding of how molecular and biochemical information is processed during the maintenance of or changes in cell fate remains elusive. Our laboratory has developed an integrated approach beginning with robust inhibitory RNA (RNAi) down regulation of key regulatory gene-products followed by global profiling of molecular and biochemical changes as a function time following a specific RNAi mediated perturbation. These dynamic analyses include profiling of epigenetic changes, transcriptional activity, changes in mRNA and miRNA levels, changes in the proteome and post-translational modifications. All analyses are performed on genome wide levels. Other studies in the laboratory are focused on understanding how the epigenetic machinery interacts with transcriptional regulatory networks, and how genome stability interfaces with the pluripotent state. Our efforts also incorporate sophisticated computational approaches as a means of integrating our own high-throughput datasets to gain a view of how information flows through the different regulatory layers, beginning with the epigenome and progressing through to the proteome. We also integrate our datasets with prior knowledge databases as an additional means of uncovering interesting biological information. Collectively, our studies reveal for the first time how dynamic changes at multiple molecular and biochemical levels occur in real time during the course of an alteration in cell fate. We also have a strong interest in utilizing iPSC techniques to develop models of important human diseases. Our initial focus has been on diseases with defined mutations in important signaling pathways. Other efforts are directed at neurological and cardiovascular disorders. We have generated patient specifc iPSC lines and have successfully modeled hypertrophic cardiomyopathy in vitro. The latest results from our systems level as well as disease modeling efforts will be presented.
Meperidine-Promethazine Combination and Learning Function of Mice and Their Progeny (1983)

Chalon, J.; Walpert, L.; Ramanathan, S.; Eisner, M.; Tang, C-K; Katz, R.; Turndorf, H.; Smith, Bradley E. M.D. Author Information
Work disability in rheumatic diseases: Baseline results from an inception cohort (2020)

Rheumatic diseases impose significant work disability at diagnosis, highlighting the need for identification and interventions targeting work disability early in the course of disease.
Optimized innovative improvements to automotive current-limited micro-hybrid starter motors (2016)

This paper is the sequel of a previous one [1] that introduced an innovative concept, validated both through modeling in time/frequency domains, and measuring its electrical effects on a prototype. This work finds here an outcome with the complete design of a product which turns to be mass-manufactured for the micro-hybrid or Stop-Start automotive market, after satisfying multiple requirements under harsh and contradictory constraints. From initial concept to a final definition, it was necessary to implement innovations from the field of electrical engineering, and to operate specific processes of numerical optimization suited to that kind of devices. The patented improvements are described, then several optimization processes are shown, that illustrate how too simple approaches lead to no solution, while implementing a multiply-constrained and multi-objective modern method, with the right tuning of its parameters, is successful.
Table S4 from Chemogenomic Landscape of <i>RUNX1</i>-mutated AML Reveals Importance of <i>RUNX1</i> Allele Dosage in Genetics and Glucocorticoid Sensitivity (2023)

&lt;p&gt;List of 100 genes most differentially expressed genes in RUNX1mut AML (n=47) compared to RUNX1wt AML (n=368).&lt;/p&gt;
Data from Long-term Follow-up of Standard-Dose Pembrolizumab Plus Reduced-Dose Ipilimumab in Patients with Advanced Melanoma: KEYNOTE-029 Part 1B (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Combination therapy with reduced-dose programmed death 1 inhibitor plus standard-dose cytotoxic T-lymphocyte–associated antigen 4 inhibitor demonstrated efficacy, but substantial toxicity, in melanoma. We present long-term results of part 1B of KEYNOTE-029, which assessed safety and efficacy of standard-dose pembrolizumab plus reduced-dose ipilimumab in advanced melanoma.&lt;/p&gt;Patients and Methods:&lt;p&gt;Part 1B was an expansion cohort of the open-label, phase Ib portion of KEYNOTE-029. Eligible patients had advanced melanoma and no previous immune checkpoint inhibitor therapy. Patients received pembrolizumab 2 mg/kg (amended to 200 mg) every 3 weeks plus ipilimumab 1 mg/kg every 3 weeks (four cycles), then pembrolizumab alone for up to 2 years. Primary end point was safety; secondary end points included objective response rate (ORR), progression-free survival (PFS), duration of response (DOR), and overall survival (OS).&lt;/p&gt;Results:&lt;p&gt;A total of 153 patients received at least one dose of pembrolizumab plus ipilimumab. At a median follow-up of 36.8 months, 71.9% had received four doses of ipilimumab and 30.7% had completed 2 years of pembrolizumab; 26.1% completed both treatments. Treatment-related adverse events occurred in 96.1% (47.1% grade 3/4; no deaths), leading to discontinuation of one or both study drugs in 35.9%. ORR was 62.1% with 42 (27.5%) complete and 53 (34.6%) partial responses. Median DOR was not reached; 36-month ongoing response rate was 84.2%. Median PFS and OS were not reached; 36-month rates were 59.1% and 73.4%, respectively.&lt;/p&gt;Conclusions:&lt;p&gt;Standard-dose pembrolizumab plus reduced-dose ipilimumab demonstrated robust antitumor activity, durable response, and favorable long-term survival with manageable toxicity.&lt;/p&gt;&lt;/div&gt;
Ceramic-Based Flexible Sheet Electrolyte for Li Batteries (2020)

The increasing demand for high-energy-density batteries stimulated the revival of research interest in Li-metal batteries. The garnet-type ceramic Li<sub>7</sub>La<sub>3</sub>Zr<sub>2</sub>O<sub>12</sub> (LLZO) is one of the few solid-state fast-ion conductors that are stable against Li metal. However, the densification of LLZO powders usually requires high sintering temperatures (e.g., 1200 °C), which likely result in Li loss and various side reactions. From an engineering point of view, high-temperature sintering of thin LLZO electrolytes (brittle) at a large scale is difficult. Moreover, the high interfacial resistance between the solid LLZO electrolytes and electrodes is a notorious problem. Here, we report a practical synthesis of a flexible composite Al-doped LLZO (Al-LLZO) sheet electrolyte (75 μm in thickness), which can be mass-produced at room temperature. This ceramic-based flexible sheet electrolyte enables Li-metal batteries to operate at both 60 and 30 °C, demonstrating its potential application for developing practical Li-metal batteries.
BEAM: design and characterization of a 10-Gb/s broadband electroabsorption modulator (2004)

The market for data modulators at 10 Gb/s is currently dominated by Mach-Zehnder phase modulators fabricated in LiNbO<sub>3</sub> (LN). However they are relatively expensive to manufacture and large compared to semiconductor devices. InP based electroabsorption modulators (EAMs), are more compact; however they have a limited bandwidth (5-8 nm) over which chirp is in the correct range to allow >80 km reach. This paper reports the broadband electroabsorption modulator (BEAM) concept in which reach performance in line with LN modulators can be achieved using integrated InP components. The BEAM consists of a series of EAMs, each one tuned to give the correct chirp over a certain wavelength range. The bandwidth of the BEAM can be extended to cover the C-band (1535nm-1565nm). In addition, a semiconductor optical amplifier (SOA) is serially integrated in order to recover the total insertion loss. Details of the design, fabrication and testing of prototype BEAM chips operating at 10 Gb/s are reported. Quantum well intermixing technology is employed to realize the multiple bandgaps required for the prototype chips which are fabricated on semi-insulating InP substrates. Highlights of the operational characteristics of the BEAM chips include extinction ratios of up to 12 dB at 10 Gb/s and SOA gains of 20 dB.
Phase Behavior of Ordered Diblock Copolymer Blends:  Effect of Compositional Heterogeneity (1996)

Diblock copolymers order into a variety of periodic morphologies when the constituent blocks are sufficiently incompatible. Previous studies have demonstrated that classical dispersion (spherical and cylindrical) and lamellar morphologies, as well as complex morphologies (e.g., gyroid*, lamellar catenoid, and hexagonally perforated lamellae), can be selectively accessed through either tailored molecular synthesis or copolymer/homopolymer blends. In the present work, control over ultimate morphology is achieved through the use of binary copolymer blends composed of two strongly-segregated poly(styrene-b-isoprene) (SI) diblock copolymers of equal molecular weights but different compositions (one 50 wt % S and the other 85 wt % S). Blend morphologies are examined by electron microscopy (including three-dimensional imaging) and small-angle X-ray scattering, and a theoretical framework is proposed to describe strongly-segregated copolymer blends exhibiting the lamellar morphology. Results obtained here indicate that diblock copolymer blends of a given bulk composition may exhibit coexisting morphologies but in general behave as single-phase diblock copolymers of equal molecular composition, suggesting that such blends offer an alternative, and attractive, route by which to generate a desired morphology.
New Systems for Studying Intercellular Interactions in Bacterial Vaginosis (2016)

Bacterial vaginosis (BV) affects almost a quarter of US women, making it a condition of major public health relevance. Key questions remain regarding the etiology of BV, mechanisms for its association with poor reproductive health outcomes, and reasons for high rates of treatment failure. New model systems are required to answer these remaining questions, elucidate the complex host-microbe and microbe-microbe interactions, and develop new, effective interventions. In this review, we cover the strengths and limitations of in vitro and in vivo model systems to study these complex intercellular interactions. Furthermore, we discuss advancements needed to maximize the translational utility of the model systems. As no single model can recapitulate all of the complex physiological and environmental conditions of the human vaginal microenvironment, we conclude that combinatorial approaches using in vitro and in vivo model systems will be required to address the remaining fundamental questions surrounding the enigma that is BV.
Abstract 3586: The use of kinome profiling to determine potential resistance pathways in pancreatic cancer cells treated with PIM kinase inhibitors (2015)

Abstract Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent cancer of the pancreas with a 5-year survival rate of 6%, making it the 4th most common cause of cancer deaths in the United States. One of the challenges related to this cancer is the issue of chemoresistance. Chemoresistance renders most drugs ineffective in the treatment of PDAC, including kinase inhibitors and the chemotherapeutic drug gemcitabine. PIM (Proviral Integration site for the Moloney murine leukemia virus) kinases are a family of proteins shown to play an important role in the chemoresistance of many cancers, including pancreatic cancer. PIMs act downstream of the JAK-STAT cytokine signaling pathway and phosphorylate substrates involved in numerous cell functions including cell cycle progression and apoptosis. One objective of our research was to determine the role of PIM kinases on transformed phenotypes of PDAC cells. We were able to demonstrate that the PIM kinase inhibitor SGI-1776 and TP-3654, a second generation PIM kinase inhibitor, were able to inhibit growth in cell viability assay. Also, the PIM inhibitors were able to decrease various phenotypes such as anchorage-dependent and anchorage-independent growth in MIA PaCa-2 and PANC-1 cells. A second objective was to determine if PIM kinase inhibitors could reduce chemoresistance in PDAC cells. PIM inhibitors in combination with gemcitabine decreased cell viability in PDAC cells significantly more than when administered separately. To investigate resistance pathways activated in PDAC cells after treatment with PIM kinase inhibitors, we applied multiplexed inhibitor beads (MIBs) mass spectrometry (MS) to profile the kinome. We observed numerous kinases that were downregulated or upregulated after treatment. One of the kinases upregulated was IKKα, a key kinase in the anti-apoptotic NF-κB signaling pathway. Our results suggest that PIM kinases are an important target for cell growth and chemoresistance in pancreatic cancer. Also, these results suggest that treating PDAC cells with a PIM inhibitor simultaneously with an IKK inhibitor might prevent the effects of resistance pathways. Overall, our studies demonstrate that kinome profiling is an effective strategy to identify cellular responses to PIM kinase inhibitors as well as other drugs for treating pancreatic and other cancers. Citation Format: Vandana Singh, Brittany Nixon, T.S. Karim Gilbert, Steve Warner, David Bearss, Lee M. Graves, Antonio T. Baines. The use of kinome profiling to determine potential resistance pathways in pancreatic cancer cells treated with PIM kinase inhibitors. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3586. doi:10.1158/1538-7445.AM2015-3586
SYMBIOTIC ALGAE AND14C INCORPORATION IN THE FRESHWATER CLAM,ANODONTA (1980)

1. Specimens of a freshwater clam Anodonta were found to be symbiotized with zoochlorellae. Larger, hence older, clams showed a greater degree of infection with algae. 2. In the light, clams exposed to the precursor NaH14CO3 showed a greater incorporation of 14C than corresponding control animals incubated in the dark. The difference is thought to result from the photosynthetic activities of the zoochlorellae. 3. Chemical fractionation of selected host tissues revealed that in the light, 14C appeared in greatest amount in the small molecule fraction though it was also detected in other fractions. 4. The major source of 14C in the hosts incubated in light is thought to be photosynthetic products translocated by the zoochlorellae. This view is strengthened by data showing that the symbionts can translocate to the medium when the algae are incubated in vitro.
A study of EEG signals modeling for different scent intensity levels (2013)

Entropy is a measure of information carried by a signal. It has also been used as a feature for the modeling or classification of signals. In this paper, we investigate the use of entropy for modeling EEG (Electroencephalography) based scent intensity levels. The paper examines three variations of the entropy design (i.e. entropy ratio, entropy difference, and entropy mean) and two other parameters namely root-mean-square (RMS), and Kurtosis. In order to derive the feature vectors, EEG signals are collected from 14 healthy volunteer human subjects on two levels of scent intensities. The results show that, EEG signals with higher scent stimulation have lower feature parameter values for all the five features considered. The feature vectors are also observed to clutter together for the same intensity level. A mathematical model using the five features is also proposed to represent or differentiate the intensity levels. An example of 3D visualization using three of the features considered is given to illustrate the modeling concept. In comparison to previous works, our paper focuses on the use of a mathematical model, involving variations of entropy as the features, to represent and differentiate EEG signals generated in response to different scent intensity levels.
Effect of Royal Jelly Diet on the Testicular Function of Hamsters (2004)

To investigate the long-term effect of feeding royal jelly (RJ) on the testicular function, 32-week old male golden hamsters were fed diet containing RJ at doses of 0 μg/g diet (control), 50 μg/g diet or 500 μg/g diet for 12 weeks. At the end of the experiment, the hamsters were assessed for testicular function in terms of the amounts of intra-testicular free testosterone (TS) and histopathological changes. RJ diet groups showed higher TS levels and more intensive spermatogenesis than the control group in a dose-dependent manner. The intensity of spermatogenesis and TS levels in the 500 μg of RJ/g diet group showed significant differences of p < 0.01 and p < 0.05, respectively, when compared with those in the control group. These results indicate that the long-term feeding of RJ inhibits the age-associated decline in the testicular function of male hamsters.
New technology on the horizon: Fast analytical screening technique FNA (FAST‐FNA) enables rapid, multiplex biomarker analysis in head and neck cancers (2020)

PD-L1 profiling was recently approved by the US Food and Drug Administration as a companion diagnostic for anti-PD1 treatment in patients with head and neck cancer, ushering in a new era for precision medicine. However, the routine development and implementation of such testing is still limited by current clinical workflows and the lack of better and more comprehensive alternatives. In this review, the authors discuss the real-world challenges of clinically based biomarker testing and highlight the advantages of developing fine-needle aspiration (FNA)-based biomarker testing that would enable frequent and serial tumor sampling. A conceptual and technological innovation is introduced, fast analytical screening technique (FAST)-FNA (FAST chemistry-enabled FNA), which is being developed to inform immunotherapy treatment options in patients with head and neck cancer and to assist with the development of the next generation of predictive biomarkers.
Contrast-Enhanced CT Colonography in Recurrent Colorectal Carcinoma (2002)

Suboptimal sigmoid distention can be seen on contrast-enhanced CT colonography, predominantly in patients with right hemicolectomies. Contrast-enhanced CT colonography is a promising method for detecting local recurrence, metachronous disease, and distant metastases in patients with prior invasive colorectal carcinoma. The technique can also serve as a useful adjunct to colonoscopy by detecting local recurrences or metachronous disease that are endoscopically obscure or by serving as a full structural colonic examination when endoscopy is incomplete.