gebhart/patrepeval huggingface dataset:
Inflammation: The Role of Endothelial Cells (2017)

This chapter provides a summary of the endothelium-dependent responses that accompany inflammation, using inflammatory bowel disease (IBD) as a prototype for pathologic conditions that manifest both acute and chronic inflammatory responses. Vasomotor dysfunction has been documented in patients with IBDs, with the dysfunction involving endothelium-dependent pathways of control. The endothelium produces several mediators that contribute to the tone of the adjacent vascular smooth muscle cells. Two inhibitors of myosin light chain kinase (MLCK) are cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), which is controlled in part by mediators released by the inner layer of the blood vessel, the endothelial cells. The diverse responses of the microcirculation to inflammation likely reflect the collective contribution of a variety of cells, including blood cells, endothelial cells, vascular smooth muscle (VSM), and perivascular cells. However, endothelial cells appear to have a unique role in modulating the inflammatory response.
Extended continuum configurational bias Monte Carlo methods for simulation of flexible molecules (1995)

The continuum configurational bias (CCB) Monte Carlo method has been extended to perform elementary moves that involve the rearrangement of inner segments of flexible chains. When regrowing inner sites, the continuity with the rest of the chain is ensured by disregarding those configurations that would imply an unrealistic elongation of the bonds once the chain is reconstructed. The formalism presented here also allows the simulation of branched chains and crosslinked-network structures. The Monte Carlo elementary moves proposed in this work are used in conjunction with an alternative method of preferential sampling in which the segments to be rearranged are chosen from a preselected region of space. The performance and capabilities of the new moves are compared to those of standard CCB and crank-shaft algorithms for simulation of melts and solutions of hard-sphere chains at high densities. Our results indicate that the methods presented here provide a fast relaxation of the bond orientation and the end-to-end orientation autocorrelation functions. Our isobaric simulations for homopolymer chains of up to 51 sites and for concentrated solutions of chain molecules in the monomer are consistent with previously reported data obtained by approximate molecular dynamics methods and by conventional Monte Carlo methods. However, small disagreements with existing data are identified at high densities. These PV results are also compared to the predictions of two recent equations of state. This comparison shows the presence of some small but systematic deviations.
Information Limits of Optical Coherence Imaging Through Scattering Media (2009)

We develop an information-theoretic framework for the quantitative assessment of the maximum amount of information provided by optical coherence imaging through scattering media. We use our approach to investigate the fundamental dependence of the extractable information on the nature of the coherent imaging process, such as on speckle formation. We present nontrivial predictions for the maximum amount of information detected by optical coherence tomography (OCT) from within homogeneous and heterogeneous scattering media and explore its behavior against coherence length and dimension of the detection array. Extension to additional coherent and incoherent light imaging approaches is also discussed.
Technical Note—Maximal Funnel-Node Flow in an Undirected Network (1973)

This note formulates, examines, and solves a funnel-node maximal-flow problem for an undirected network. The solution procedure requires only applications of the single-commodity flow algorithm, and is therefore extremely efficient. Several applications are presented.
Binding of a dimeric derivative of vancomycin with L-Lys-D-Ala-D-Lactate in solution and at surface: Insights into its enhanced activity against vancomycin-resistant bacteria. (1998)

Mathematical Immunogenetics I argued for the development of mathematics as a language for immunogenetics. A three-fold factorization of a reaction matrix was seen to be the important form of a model of a first order immunogenetic system. In the present paper, results of the authors on determining this factorization are reworked from a physical perspective and presented in an algorithmic form that can be used to compute a labeling matrix from data. Computer programs to perform these computations are in preparation.
The Effect of Quantization and Coulomb Friction on the Stability of Haptic Rendering (2005)

Rendering stiff virtual objects remains a core challenge in the field of haptics. A study of this problem is presented, which relates the maximum achievable object stiffness to the elements of the control loop. In particular, we examine how the sampling rate and quantization of position measurements interact with the inertia, natural viscous, and Coulomb damping of the haptic device. The resulting stability criterion generalizes previously known conditions. Simulations and experimental results support the theoretical analysis based on the passivity and describing function approaches.
Distributed phase shifters using (Ba,Sr)TiO3 thin films on sapphire and glass substrates (2001)

Abstract In this paper, we present distributed phase shifter results employing voltage tunable (Ba,Sr)TiO3 (BST) thin film capacitors deposited by RF magnetron sputtering. Both parallel-plate and interdigital structures are investigated for different application requirements. The parallel-plate capacitor based circuit on glass (Vycor) substrate has a continuous 0–180? phase shift at 30 GHz with an insertion loss of 4dB and return loss better than 12 dB. A similar K-band phase shifter on a sapphire substrate was also demonstrated with a 0–270? differential phase shift and an insertion loss of 6.1dB at 20 GHz. The circuit using interdigital BST capacitors on sapphire substrate shows a continuous 0–360? phase shift at 8.2 GHz with an insertion loss of only 4.9 dB. These results show the feasibility of using BST thin film technology in microwave and millimeter wave phase shifter applications.
Gastrointestinal disease burden and mortality: A public hospital‐based study from 2005 to 2014 (2018)

This study showed an increased hospitalization burden of GI cancers and Crohn's disease, and a reduction in overall mortality for GI diseases. These data provide insight into epidemiological changes of GI diseases in the 21st century and implications for hospital burden and need of resource re-allocation.
Accurate Mass Tag (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Small-scale Coherent EUV Light Sources from High-Harmonic Generation (2002)

Coherent EUV light can be generated using the process of high‐harmonic upconversion of pulses from a high‐intensity femtosecond laser. Recent advances in ultrafast laser technology, combined with the development of efficient techniques for high‐harmonic generation (HHG), now make routine small‐scale, table‐top experiments using coherent EUV light. New advances, such as the use of pulse shaping and quasi‐phase matched geometries, give new flexibility in the design of coherent EUV sources.
Clinical and molecular analyses of deletion 3p25‐pter syndrome (1993)

Hemizygous deletion of 3p25-pter is associated with a phenotype of profound growth failure, microcephaly, characteristic facial changes, and mental retardation. Since the severity may be quite variable, we have studied 3 cases of del 3p25-pter to define the clinical manifestations and the critical chromosome region for phenotypic expression. The patient we now report died at age 6 months and provided an opportunity for a detailed necropsy analysis for only the second time in a del(3p) patient. He had marked hypoplasia of all organs, hypomyelination of white matter, and multiple renal cortical microcysts. Ordered genomic markers from the distal regions of chromosome 3p aided in determining the parent of origin of each deletion and in defining the boundaries of the deleted chromosomal segments. The deleted markers distal to the RAF1 oncogene in 2 of the 3 patients were consistently hemizygous. One patient had an interstitial deletion based on evidence of diploid inheritance of one of the most distal loci (D3S17). Available genetic linkage maps suggest that the deletion spans at least 19 centimorgans (cM).
Datamation 2001: A Sorting Odyssey (2001)

We present our experience of turning a Linux cluster into a high-performance parallel sorting system. Our implementation, WIND-SORT, broke the Datamation record by roughly a factor of two, sorting 1 million 100-byte records in 0.48 seconds. We have identied three keys to our success: developing a fast remote execution service, conguring the cluster properly, and avoiding the potential ill-effects of occasionally faulty hardware.
Low-loss and fabrication-tolerant Si four-wavelength multiplexer using higher-order mode for 100/400GbE (2019)

A Si four-wavelength multiplexer for 100/400GbE composed of (a)symmetric directional couplers and a rib-waveguide mode-converter is experimentally demonstrated. Proposed device is fabrication-tolerant due to the removal of 1600-GHz filter used in conventional two-stage Mach-Zehnder multiplexers.
Using RPI Option Type, Routing Header for Source Routes, and IPv6-in-IPv6 Encapsulation in the RPL Data Plane (2021)

This document looks at different data flows through LLN (Low-Power and
Lossy Networks) where RPL (IPv6 Routing Protocol for Low-Power and
Lossy Networks) is used to establish routing. The document enumerates
the cases where RFC6553 (RPI Option Type), RFC6554 (Routing Header for
Source Routes) and IPv6-in-IPv6 encapsulation is required in data
plane. This analysis provides the basis on which to design efficient
compression of these headers. This document updates RFC6553 adding a
change to the RPI Option Type. Additionally, this document updates
RFC6550 defining a flag in the DIO Configuration option to indicate
about this change and updates [RFC8138] as well to consider the new
Option Type when the RPL Option is decompressed.
Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer (2022)

Abstract Altered RNA expression of repetitive sequences and retrotransposition are frequently seen in colorectal cancer, implicating a functional importance of repeat activity in cancer progression. We show the nucleoside reverse transcriptase inhibitor 3TC targets activities of these repeat elements in colorectal cancer preclinical models with a preferential effect in p53-mutant cell lines linked with direct binding of p53 to repeat elements. We translate these findings to a human phase II trial of single-agent 3TC treatment in metastatic colorectal cancer with demonstration of clinical benefit in 9 of 32 patients. Analysis of 3TC effects on colorectal cancer tumorspheres demonstrates accumulation of immunogenic RNA:DNA hybrids linked with induction of interferon response genes and DNA damage response. Epigenetic and DNA-damaging agents induce repeat RNAs and have enhanced cytotoxicity with 3TC. These findings identify a vulnerability in colorectal cancer by targeting the viral mimicry of repeat elements. Significance: Colorectal cancers express abundant repeat elements that have a viral-like life cycle that can be therapeutically targeted with nucleoside reverse transcriptase inhibitors (NRTI) commonly used for viral diseases. NRTIs induce DNA damage and interferon response that provide a new anticancer therapeutic strategy. This article is highlighted in the In This Issue feature, p. 1397
5. Zelltherapeutika auf der Basis humaner pluripotenter Stammzellen: internationale klinische Studien im Überblick (2018)

Stammzellforschung , Seite 115 - 138
Rain clouds tracking with radar image processing based on morphological skeleton matching (2002)

The aim of this study is to perform a short term forecasting of dynamic radar clutter evolution (shape and position). This dynamic clutter, like thunderstorms, can be tracked by means of adapted algorithms based on the matching of the morphological skeleton polygonal approximation by relaxation labeling processes. The efficiency of our methods is demonstrated on meteorological radar images. The objective of this application is dedicated to civil traffic regulation according to severe atmospheric phenomenon, as described in Monnier & al. (1997). Through radar environment assessment, we observe radar clutter, like precipitation, submitted to very complex deformations that cannot be modelized easily. In Barbaresco (1999), we proposed a method based on morphological skeleton deformation to forecast the fluid topological evolution. This method allows management of very complex shapes evolution thanks to polygonal approximation of the skeletons and matching of their closed couple of elements by the relaxation algorithm. The skeleton simplifies shape analysis and deformation but also distinguishes clutter displacement and articulated deformation by skeleton matching from homothetic deformation (inflation and deflation) by medial axis (radius of maximal disks contained in the shape) tracking.
Identification of bacteriocin-producing Lactobacillus paraplantarum first isolated from kimchi (2005)

A bacteriocin-producing lactic acid bacterium with inhibitory activity against the growth of Lactobacillus plantarum was isolated from kimchi, a traditional Korean fermented vegetable. For the identification of the isolate, its 16S rDNA was sequenced. As a result, the sequence showed 99% homology with those from Lactobacillus paraplantarum, Lb. plantarum, and Lactobacillus pentosus. For further identification of the isolate, the sequence of its 16S/23S rDNA spacer region was determined, and the sequence matched perfectly with that of Lb. paraplantarum. SDS-PAGE fingerprinting of whole-cell proteins of the isolate was almost identical with that of Lb. paraplantarum. The isolation and identification of Lb. paraplantarum suggest that Lb. paraplantarum is one of the lactic acid bacteria involved in kimchi fermentation.
Supplementary figure legends from Regulation of eIF4F Translation Initiation Complex by the Peptidyl Prolyl Isomerase FKBP7 in Taxane-resistant Prostate Cancer (2023)

&lt;p&gt;Supplementary figure legends&lt;/p&gt;
A Multidisciplinary Airplane Research Integrated Library With Applications To Partial Turboelectric Propulsion (2019)

The aim of this paper is to present a new model library developped as a new test case to benchmark optimization algorithms and Multidisciplinary Design Optimization (MDO) formulations. It introduces the MARILib software (Multidisciplinary Airplane Research Integrated Library). MARILib's first objective is to provide models for research on a wide range of aircraft concepts, from business jets to super jumbos, and also some unconventional configurations, through an Overall Aircraft Design (OAD) approach. The second objective is to share a new benchmark test case for MDO strategies, which does not raise intellectual property issues. The third objective is to describe a case study for educational and training purposes. MARILib will be available as Open Source. 1. Nomenclature Without special notice, all units are international standard units. (.) f an = quantity related to the fan (.) Fr ee Str eam = quantity related to free stream (.) hybrid = quantity related to the hybrid architecture (.) I nlet = quantity related to the inlet (.) jet = quantity related to the jet (.) 0 = quantity related to reference turbofan without hybridation δ 0 = theoretical boundary layer thickness around a cylindrical fuselage of length L δ 1 = assessed boundary layer thickness around the e-fan hub δ = boundary layer thickness η eF = propeller like e-fan efficiency η C = wire conductivity efficiency *
Mapping a cardiomyopathy locus to chromosome 3p22-p25. (1996)

Dilated cardiomyopathy (DCM) is a common disorder characterized by cardiac dilation and reduced systolic function. To identify a cardiomyopathy gene, we studied a family with DCM associated with sinus node dysfunction, supraventricular tachyarrhythmias, conduction delay, and stroke. A general linkage approach was used to localize the disease gene in this family. Linkage to D3S2303 was identified with a two-point lod score of 6.09 at a recombination fraction of 0.00. Haplotype analyses mapped this locus to a 30 cM region of chromosome 3p22-p25, excluding candidate genes encoding a G-protein (GNAI2), calcium channel (CACNL1A2), sodium channel (SCN5A), and inositol triphosphate receptor (ITPR1). These data indicate that a gene causing DCM associated with rhythm and conduction abnormalities is located on chromosome 3p, and represent the first step toward disease gene identification.
A review of cesium thermionic converters with developed emitter surfaces (1996)

Studies from US and Russian literature on experimental and theoretical investigations of thermionic converters with developed emitter surfaces are reviewed and analyzed. Experimental data for these converters is compared with that for close‐spaced and traditional Cs arc converters. The former is most advantageous at low temperatures from 1300 to 1700 K, with the power gain increasing as the emitter temperature decreases and/or its emission properties deteriorate. This power gain is attainable at a larger load voltage and at a significantly larger optimum interelectrode gap size than traditional converters. Additional experiments and mathematical modeling are needed to understand the physical processes taking place and assess the performance of thermionic converters with developed emitter surfaces, compared to traditional ones operating under identical conditions.
Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation (1999)

A cDNA encoding p55PIK, one of the regulatory subunits of phosphoinositide (phosphatidylinositol) 3-kinase, was cloned from a cDNA library derived from the mouse mammary epithelial cell line C57MG. The cDNA coding for full-length p55PIK was transiently expressed in COS-7 cells. Western blot analysis of p55PIK expression using a specific antibody against p55PIK revealed that multiple protein products with different molecular masses were detected in COS-7 cell extracts. Experiments presented here demonstrate that multiple forms of p55PIK detected in COS-7 cells were produced by alternative initiation of translation. We also show that at least two in-frame start codons (AUG#2 and AUG#5) in p55PIK mRNA are used in COS-7 cells for the initiation of translation of p55PIK into proteins of 54 kDa and 50 kDa respectively. p55PIK mRNA was also alternatively translated into two proteins in PC cells, a mouse teratoma cell line, indicating that the alternative initiation of translation of p55PIK is not restricted to COS-7 cells. Results from immunoprecipitation and Western blot analysis showed that two forms (54 kDa and 50 kDa protein species) of p55PIK were detected in C57MG cells. Interestingly, when C57MG cells were treated with insulin, only p55PIK, but not p50PIK, bound to insulin receptor substrate-1 protein, providing evidence that different forms of p55PIKs may have specific distinct roles in signal transduction pathways.
RF Printed Circuit Partially Combined With the inkjet-Printing Technology (2021)

In this paper we propose RF printed circuit partially combined with the inkjet-printing technology. Since the inkjet printing technology can customize circuit patterns easily, it is suitable for custom production. However, the ink for the inkjet-printing has a lower conductivity than copper foil which has been generally used for conventional printed circuits. The low conductivity causes loss in the RF circuit. In order to solve this problem, we propose RF printed circuit partially combined with the inkjet-printing technology. In the proposed method, we firstly prepare the common printed circuit boards that are produced by the conventional printing technologies such as chemical etching, and then customize them on demand by minimum inkjet-printing. This method realizes custom production of various circuits. in addition, it can reduce inkjet pattern area and loss in RF circuit.
<title>Experimental investigation of a passive stand-off layer damping treatment applied to an Euler-Bernoulli beam</title> (1999)

Passive stand-off layer (PSOL) damping treatments are presently being implemented in many aerospace and defense designs. In a PSOL damping treatment, a stand-off or spacer layer is added to a conventional passive constrained layer (PCL) damping treatment. The addition of this stand-off layer increases the distance of the viscoelastic and constraining layers from the neutral axis of the vibrating structure. This is thought to enhance the damping by increasing the shear angle of the viscoelastic layer. In this experimental study, a PSOL damping treatment was applied to an Euler-Bernoulli beam. The frequency response of the treated PSOL beam was then compared with a conventionally treated PCL beam of similar dimensions and materials. Previous theoretical studies indicated that PSOL treatments provided greater damping than similarly sized conventional PCL treatments. This study verified experimentally that the beam treated with PSOL had greater damping of the first four modes than a similarly sized beam treated with PCL.
Efficient electrothermal actuation of multiple modes of high-frequency nanoelectromechanical resonators (2007)

The authors observed resonances from multiple vibrational modes of individual silicon-carbide-based nanomechanical resonators, covering a broad frequency range from several megahertz to over a gigahertz. The devices are actuated thermoelastically in vacuum at room temperature using localized Joule heating in a device-integrated metal loop. Their motion is detected piezoresistively using signal downmixing in a similarly integrated metal piezoresistor. The frequencies and amplitudes of the observed resonant peaks are in good agreement with the results from theoretical modeling and finite-element simulations.