gebhart/patrepeval huggingface dataset:
Thermal analysis and dissolution characteristics of nifedipine solid dispersions (2020)

Solid dispersions of nifedipine prepared with two hydrophilic carrier systems, Gelucire (44/14)/PEG 600 and PVP (K12-K25)/PEG 6000 by fusion or fusion/solvent method were characterized by thermal analysis for comparisons. Results demonstrated that both carrier systems were able to prohibit the crystallization of nifedipine after the mixture melted at a higher temperature at a ratio exceeding 50%. The extent of forming amorphous nifedipine due to the inhibition of crystallization, also raised with the increasing ratio of the carrier. When mixing with PEG 6000 at a ratio of 3:1, the melting temperature of nifedipine dropped to 110°C. Dissolution tests further demonstrated that nifedipine, once fused with these carriers, possessed an enhanced dissolution rate. As to the Gelucire (44/14)/PEG 600 system, the dissolution rates from those samples prepared at a higher temperature were faster than those prepared at the melting point of Gelucire. The dissolution rate increased with the amount of Gelucire added in the preparation. For the PVP/PEG 6000 carrier system, the dissolution rate of nifedipine increased with the amounts of both PVP and PEG 6000. However, a slower dissolution rate was also noted resulted from higher molecular weight of PVP.
Application of two-photon microscopy to elucidate oleic-acid-induced changes in microscale transdermal transport processes (2001)

In a novel application of two-photon scanning fluorescence microscopy (TPM), three-dimensional spatial distributions of the hydrophilic and hydrophobic fluorescent probes, sulforhodamine B (SRB) and rhodamine B hexyl ester (RBHE), in excised full-thickness human cadaver skin were visualized and quantified. These findings utilizing TPM demonstrate that, in addition to providing three-dimensional images that clearly delineate probe distributions in the direction of increasing slun depth, the subsequent quantification of these images provides additional important insight into the mechanistic changes in transdermal transport underlying the visualized changes in probe distributions across the slun.
The CODA System for Monologue-to-Dialogue Generation (2011)

This paper describes an implemented monolingual Text-to-Text generation system. The system takes monologue and transforms it to two-participant dialogue. The system uses mappings between discourse relations in text and dialogue acts in dialogue. These mappings are extracted from a parallel monologue and dialogue corpus.
Silicon carbide integrated circuits for extreme environments (2013)

Analog and digital integrated circuits capable of operating reliably at 300 °C for 2000 hours were designed and fabricated in silicon carbide. These circuits are critical for the development of tools and instrumentation for geothermal exploration. Lateral MOSFETs and resistors were built on Si-face, 4°-off, N+ 4H-SiC substrates. Compact models of these devices were then generated and used to design the circuits, including operational amplifiers, ring oscillators, counters, shift registers and logic gates. The circuits were then fabricated and packaged using specially developed high temperature packaging processes. The integrated circuits were designed to interface with sensors and transducers to produce analog signals that can be digitized and transmitted via a telemetry system capable of sustained operation at 300 °C.
Objective and subjective evaluation of localisation accuracy in wave field sysnthesis (2008)

cote interne IRCAM: Sanson08a
Preclinical evaluation of 89Zr-DBN based virus labeling method for PET imaging of virus trafficking (2016)

1139 Objectives There is a growing interest in virus-based gene therapies, but like drugs, a better understanding of their pharmacokinetics is critical to their advancement. This study evaluates a novel virus labeling approach with 89Zr (T1/2 =78.4h) for PET imaging of in vivo virus trafficking. Methods A novel 89Zr-DBN based “one pot” virus labeling approach was developed. Various serotypes of adeno-associated viruses (AAVs) encoding a Cre gene were covalently labeled with 89Zr-DBN. The cell binding potential of 89Zr-DBN-AAV8/9 to liver hepatocytes was assessed. The physical biodistribution of 89Zr-DBN-AAV8/9 assessed by PET and the reporter gene based infection profile assessed by luminescence imaging were compared using a mouse model encoding Cre-inducible reporter genes. Results The AAVs were labeled with 89Zr with viral labeling yield of ~20mCi/1014 AAVs. The 89Zr-AAVs were able to bind liver hepatocytes. The in vivo biodistribution of 89Zr-AAVs correlated with the infection profile of the AAVs in the mouse model as monitored by bioluminescence. Conclusions The 89Zr-AAVs can be reliably tracked in vivo by high resolution non-invasive PET imaging. The major advantages of this labeling method are that it is a “one pot” mild virus labeling approach and there is no need for pre-modification of the virus for labeling.
Phase III randomized, double-blind placebo-controlled trial of rhGM-CSF following allogeneic bone marrow transplantation. (1995)

Preliminary studies in allogeneic BMT suggest that recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) is well tolerated. This is a prospective, multicenter, randomized, double-blind, placebo-controlled trial. Yeast-derived rhGM-CSF 250 micrograms/m2/day or placebo was administered by 4-hour i.v. infusion starting on the day of marrow infusion (day 0) to day 20. All patients received HLA-identical sibling marrow and cyclosporine and prednisone for GVHD prophylaxis. Fifty three patients received rhGM-CSF and 56 received placebo. Comparison of demographics revealed no differences. The time to achieve an absolute neutrophil count of > 0.5 x 10(9) cells/l was shortened in rhGM-CSF treated patients (day 13 vs. 17, P = 0.0001). The incidences of grade III-IV mucositis and infection were significantly reduced (P = 0.005, P = 0.001, respectively) and duration of hospitalization was modestly shortened by 1 day (P = 0.02) in rhGM-CSF treated patients. No differences in platelet recovery, erythrocyte recovery, incidence of veno-occlusive disease, GVHD severity, relapse or survival were observed. In conclusion, rhGM-CSF is well tolerated and reduces post-transplant morbidity in patients undergoing HLA-identical allogeneic BMT.
Fabrication of nanocomposite-coated foam with tailored structure and mechanical properties using Layer-by-Layer assembly for tissue engineered bone scaffold applications (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Manufacturer Usage Description URI and DHCP Option (2016)

The ability of smart objects to protect themselves will vary. A good
source of information about a device's capabilities is the
manufacturer. This document specifies a means by which devices can
communicate a URI that the network can use to retrieve simple network-
relevant information.
Advantages and special considerations in fabricating bubble circuits by electroplating and sputter etching (1974)

A technology which has been used to fabricate a 1024 bit bubble domain memory with micron dimensions is described. The process uses additive electroplating through photoresist masks to form the propagation patterns and conductors, and sputter etching to define the magnetoresistive sensor elements. Critical aspects of the process pertinent to both dimensional control and to preservation of the properties of existing magnetic material in the structure during subsequent processing are discussed. Results are cited indicating the applicability of these processes to submicron dimensions.
Recent Progresses on Materials for Electrophosphorescent Organic Light‐Emitting Devices (2010)

Although organic light-emitting devices have been commercialized as flat panel displays since 1997, only singlet excitons were emitted. Full use of singlet and triplet excitons, electrophosphorescence, has attracted increasing attentions after the premier work made by Forrest, Thompson, and co-workers. In fact, red electrophosphorescent dye has already been used in sub-display of commercial mobile phones since 2003. Highly efficient green phosphorescent dye is now undergoing of commercialization. Very recently, blue phosphorescence approaching the theoretical efficiency has also been achieved, which may overcome the final obstacle against the commercialization of full color display and white light sources from phosphorescent materials. Combining light out-coupling structures with highly efficient phosphors (shown in the table-of-contents image), white emission with an efficiency matching that of fluorescent tubes (90 lm/W) has now been realized. It is possible to tune the color to the true white region by changing to a deep blue emitter and corresponding wide gap host and transporting material for the blue phosphor. In this article, recent progresses in red, green, blue, and white electrophosphorescent materials for OLEDs are reviewed, with special emphasis on blue electrophosphorescent materials.
Context-based heterogeneous middleware integration (2009)

The use of context provision middleware is a promising approach to deal with the low-level functions involved in handling contextual events when building ubiquitous applications. Several middleware are currently available that provide support for context handling, each one adopting different models both to interact with applications and to represent contextual data. We present OpenCOPI (Open COntext Platform Integration), a platform that integrates several context provision middleware systems, providing a unified ontology-based context service for ubiquitous applications. OpenCOPI encapsulates the underlying middleware platforms and represents them as services to be provided to client applications thus facilitating the development of ubiquitous applications. This paper presents the OpenCOPI architecture, main implementation issues, and a case study that discusses the use of OpenCOPI in a ubiquitous scenario.
Author response: Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes (2022)

The emergent organization of bacterial proteomes—the integration of proteins into collective networks that encode function—can be defined purely from spectral analysis of ortholog covariation across extant diversity.
Myocardial Gene Expression Profiling to Predict and Identify Cardiac Allograft Acute Cellular Rejection: The GET-Study (2016)

Myocardial GEP is a helpful method to accurately diagnose ACR, and predicts rejection one month before its histological occurrence. These results should be considered in cardiac allograft recipients' care.
Tunable wavelength multiplexer/demultiplexer using a MEMS Gires-Tournois interferometer (2004)

In this paper, we have demonstrated a 1/spl times/3 wavelength multiplexer/demultiplexer using optical MEMS technology based on a Gires-Tournois interferometer (GTI) with a tunable center wavelength. The center wavelength of each output port was continuously tunable across the free spectral range, and, the output port assignment can therefore be cyclically interchanged. These types of wavelength tunability and port reallocation offer useful functionality in various WDM systems.
Parametrization of white matter manifold-like structures using principal surfaces (2013)

In this manuscript, we are concerned with data generated from a diffusion tensor imaging (DTI) experiment. The goal is to parameterize manifold-like white matter tracts, such as the corpus callosum, using principal surfaces. We approach the problem by finding a geometrically motivated surface-based representation of the corpus callosum and visualize the fractional anisotropy (FA) values projected onto the surface; the method applies to any other diffusion summary as well as to other white matter tracts. We provide an algorithm that 1) constructs the principal surface of a corpus callosum; 2) flattens the surface into a parametric 2D map; 3) projects associated FA values on the map. The algorithm was applied to a longitudinal study containing 466 diffusion tensor images of 176 multiple sclerosis (MS) patients observed at multiple visits. For each subject and visit the study contains a registered DTI scan of the corpus callosum at roughly 20,000 voxels. Extensive simulation studies demonstrate fast convergence and robust performance of the algorithm under a variety of challenging scenarios.
Polyanionic Microbicides Modify Toll-Like Receptor-Mediated Cervicovaginal Immune Responses (2009)

Topical microbicides are being developed as a preventative approach to reduce the sexual transmission of human immunodeficiency virus type 1 (HIV-1) and other infections. For them to be efficacious, it is believed that they should avoid inducing inflammation while allowing the vaginal epithelium to initiate protective Toll-like receptor (TLR)-mediated innate responses against pathogens. In this study, human cervical and vaginal epithelial cells were exposed to polyanionic HIV entry inhibitors and the following synthetic TLR ligands: (i) the bacterial lipoprotein Pam(3)CSK(4), binding cell surface TLR1/TLR2; (ii) macrophage activating lipopeptide 2 (MALP-2), binding cell surface TLR2/TLR6; and (iii) the viral double-stranded RNA analog poly(I:C), recognized by intracellular TLR3. Cell activation was assessed by nuclear factor kappaB (NF-kappaB) reporter gene transactivation and cytokine production. In spite of enhancing TLR-triggered NF-kappaB activation, the polyanionic microbicide compounds dextran sulfate and polystyrene sulfonate significantly inhibited TLR-mediated cytokine production. They decreased cytokine mRNA and protein levels of proinflammatory (interleukin-8 [IL-8] and IL-1beta) and antiviral (beta interferon) cytokines following epithelial cell stimulation with Pam(3)CSK(4), MALP-2, or poly(I:C). These activities were associated with the sulfate/sulfonate moieties of the polyanionic compounds, since the unsulfated dextran control did not show any effects. Our data demonstrate that these microbicide compounds are capable of selectively interfering with TLR-mediated epithelial responses at different points in their signaling pathways and underscore the importance of expanding the assessment of microbicide compatibility with vaginal innate immune function. Further studies are warranted to determine the impact of this interference on HIV-1 transmission risk.
Activation of methane with photoexcited metal atoms (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTActivation of methane with photoexcited metal atomsW. E. Billups, Mark M. Konarski, Robert H. Hauge, and John L. MargraveCite this: J. Am. Chem. Soc. 1980, 102, 24, 7393–7394Publication Date (Print):November 19, 1980Publication History Published online1 May 2002Published inissue 19 November 1980https://pubs.acs.org/doi/10.1021/ja00544a054https://doi.org/10.1021/ja00544a054research-articleACS PublicationsRequest reuse permissionsArticle Views265Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Antibody-mediated depletion of protein variant expression in living cells (Protein interference) (2017)

Abstract A significant development in the field of human biology is the revelation of millions of unannotated protein sequence variants emerging from the several human genotyping and genome sequencing initiatives. This presents unique opportunities as well as confounding challenges in our understanding of how molecular signalling outcomes vary among individuals in the general population. As a result the conventional ‘one drug fits all’ lines of approach in the drug discovery process is becoming obsolete. However, an innovative genotype-specific approach targeting protein sequence variants instead of a reference protein target is currently lacking. In this short communication we report a remarkable observation of antibody-mediated knockdown of intracellular protein expression. This suggests allele-specific inhibition of protein-variant expression can be achieved by intracellular delivery of lipid conjugated linear epitope-specific monoclonal antibodies. The results presented here demonstrate novel opportunities for interrogating the protein coding variations in the human genomes and new therapeutic strategies for the inhibition of pathogenic protein variants in a genotype-centric manner.
On the Impact of Hardware Impairments on Massive MIMO (2014)

Massive multi-user (MU) multiple-input multiple-output (MIMO) systems are one possible key technology for next generation wireless communication systems. Claims have been made that massive MU-MIMO will increase both the radiated energy efficiency as well as the sum-rate capacity by orders of magnitude, because of the high transmit directivity. However, due to the very large number of transceivers needed at each base-station (BS), a successful implementation of massive MU-MIMO will be contingent on of the availability of very cheap, compact and power-efficient radio and digital-processing hardware. This may in turn impair the quality of the modulated radio frequency (RF) signal due to an increased amount of power-amplifier distortion, phase-noise, and quantization noise. In this paper, we examine the effects of hardware impairments on a massive MU-MIMO single-cell system by means of theory and simulation. The simulations are performed using simplified, well-established statistical hardware impairment models as well as more sophisticated and realistic models based upon measurements and electromagnetic antenna array simulations.
The LD78β isoform of MIP-1α is the most potent CCR5 agonist and HIV-1–inhibiting chemokine (1999)

LD78alpha and LD78beta are 2 highly related nonallelic genes that code for different isoforms of the human CC chemokine macrophage inflammatory protein-1alpha (MIP-1alpha). Two molecular forms of natural LD78beta (7.778 and 7.793 kDa) were identified from conditioned media of stimulated peripheral blood mononuclear cells. Although LD78alpha and LD78beta only differ in 3 amino acids, both LD78beta variants were 100-fold more potent chemoattractants for mouse lymphocytes than was LD78alpha. On the contrary, LD78beta was only 2-fold more efficient than LD78alpha in chemoattracting human lymphocytes and monocytes. Using CC chemokine receptor-transfected cells, both molecular forms of LD78beta proved to be much more potent than LD78alpha in inducing an intracellular calcium rise through CCR5. Compared with LD78alpha and RANTES, this preferential binding of LD78beta to CCR5 resulted in a 10- to 50-fold higher potency in inhibiting infection of peripheral blood mononuclear cells by CCR5-using (R5) HIV-1 strains. To date, LD78beta is the most potent chemokine for inhibiting HIV-1 infection, and can be considered as a potentially important drug candidate for the treatment of infection with R5 HIV-1 strains.
Instrumentation design for adaptive SPECT/CT (2008)

We are developing instrumentation for adaptive multimodality imaging, a form of non-linear optimization where imaging parameters are automatically adjusted in response to the object. We have designed and built an adaptive, helical-scan cone-beam x-ray CT system suitable for small-animal studies and are retrofitting one of our existing FastSPECT systems to add adaptive capabilities. We discuss the system designs and how adaptive strategies can provide an increase in performance on various medical imaging tasks relative to current imaging procedures.
Reduction of Minimum Cutting Thickness of Titanium Alloys in Micro Cutting by a Magnetic Field Assistance (2019)

Ultra-precision diamond cutting (UPDC) is a promising machining technology to generate precise components with optical grade surface. However, a tool rake angle turns to be negative when the tool radius is significantly larger than cutting depth during UPDC. The resulted plowing motion, which is the well-known size effect, causes undeformed and uncut materials remaining on the machined surface and thus affects the surface integrity of final components. In this study, the tribology behavior of tool/workpiece was altered in order to resolve the problematic size effect. A magnetic field was superimposed into titanium alloys during UPDC to increase the friction coefficient at the tool/workpiece interface in order to minimize the size effect and reduce minimum chip thickness (MCT) in UPDC. The experimental results showed the friction coefficient at the tool/workpiece interface increased under the magnetic field influence and a better surface quality was achieved in the presence of magnetic field. MCT of titanium alloys was reduced to 1μm by utilizing the proposed machining technology which the reduction percentage reached to 50%. A lower MCT value means the feasibility of machining under smaller depth of cut and thus enhances the existing precise level of components fabricated in ultra-precision machining.
Antithrombotic effects of YM466, a synthesized direct inhibitor of factor Xa, in an arterio‐venous shunt thrombosis model in squirrel monkeys (2003)

Abstract The antithrombotic effects of YM466, a synthetic direct inhibitor of human factor Xa (FXa), were evaluated in an arterio‐venous shunt thrombosis model in squirrel monkeys. YM466 significantly inhibited thrombus formation after continuous IV zx infusion at doses of 3–30 µg/kg/h. Although prothrombin time (PT) was significantly prolonged at doses of 10 and 30 µg/kg/h, this effect was small (1.2‐ and 1.4‐fold of the control, respectively). Furthermore, YM466 had no effect on template bleeding time and activated partial thromboplastin time at any dose. Plasma anti‐FXa activity increased in a dose‐dependent manner correlating with the antithrombotic effect of YM466. Thrombin‐antithrombin III complex levels decreased to less than normal levels at 30 µg/kg/h of YM466. Mean plasma concentrations of YM466 measured by LC/MS/MS were 2.5, 10.5, 27.4, and 75.5 ng/ml at doses of 1, 3, 10, and 30 µg/kg/h, respectively. These results suggest that YM466 is a safe antithrombotic agent with low bleeding risk, and that plasma anti‐FXa activity may be a suitable parameter for monitoring its antithrombotic effect. Drug Dev. Res. 58:190–195, 2003. © 2003 Wiley‐Liss, Inc.