gebhart/patrepeval huggingface dataset:
Enhanced High Harmonic Generation from Multiply Ionized Argon above 500 eV through Laser Pulse Self-Compression (2009)

By combining laser pulse self-compression and high harmonic generation within a single waveguide, we demonstrate high harmonic emission from multiply charged ions for the first time. This approach enhances the laser intensity and counteracts ionization-induced defocusing, extending the cutoff photon energy in argon above 500 eV for the first time, with higher spectral intensity and cutoff energy than He for the same input laser parameters. This Letter demonstrates a pathway for extending high harmonic emission to very high photon energies using large, multiply charged, ions with high ionization potentials.
High-Tc interferometers using all YBa2Cu3O7−δ trilayer junctions (2003)

We have demonstrated high-Tc interferometers using YBaCuO trilayer junctions, which are two-junction-type interferometers with a direct current injection. In order to realize a small loop inductance value without a ground plane, the interferometers were designed to have loop inductance with a vertical stacked structure by overlapping junction bridges on base electrodes. The interferometers showed clear threshold characteristics in the control current dependence of the gate current at temperatures below 70 K. The temperature dependence of the loop inductance showed good agreement with a calculation result based on a strip-line model. The sheet inductance was estimated to be 0.85 pH/□ at 4.2 K from the threshold characteristics of the interferometers by changing the bridge length between the two junctions, which was in good agreement with the design value.
Improved method for determining inversion layer mobility of electrons in trench MOSFETs (2004)

Trench sidewall effective electron mobility (μeff) values were determined by using the split capacitance–voltage (CV) method for a large range of the transversal effective field (Eeff) from 0.1 up to 1.4 MV/cm. The influences of crystal orientation, doping concentration and, for the first time, temperature were investigated. Results show that the split CV method is an accurate method for determining μeff (Eeff) data in trench MOSFETs; the {100} μeff data approaches published data on planar MOSFETs for high Eeff; and mobility behaviour can be explained with generally accepted scattering models for the entire range of Eeff. The results are important for the optimisation of trench power devices.
Deformation Aware Augmented Reality for Craniotomy using 3D/2D Non-rigid Registration of Cortical Vessels (2020)

International audience
Biological Complication in Guided Bone Regeneration With a Polylactic Acid Membrane (2012)

We presume that this complication was a foreign body reaction to the polylactic acid membrane. Such a reaction can affect soft and hard tissue healing following GBR. Long-term follow-up is needed to determine stability of the results.
The extreme problem for Orlicz and Lq torsional rigidity and their properties (2021)

In this paper, the extreme problem for Orlicz and Lq torsional rigidity is discussed. Moreover, we introduce Orlicz and Lq geominimal torsional rigidity, which is defined as being motivated through Orlicz L' mixed torsional rigidity. Also, the invariance of Orlicz and Lq geominimal torsional rigidity under orthogonal matrices is proved, and isoperimetric type inequality and circular type inequality for the torsional rigidity are established as well.
Characterization of maize ( Zea mays L.) Wee1 and its activity in developing endosperm (1999)

We report the characterization of a maize Wee1 homologue and its expression in developing endosperm. Using a 0.8-kb cDNA from an expressed sequence tag project, we isolated a 1.6-kb cDNA (ZmWee1), which encodes a protein of 403 aa with a calculated molecular size of 45.6 kDa. The deduced amino acid sequence shows 50% identity to the protein kinase domain of human Wee1. Overexpression of ZmWee1 in Schizosaccharomyces pombe inhibited cell division and caused the cells to enlarge significantly. Recombinant ZmWee1 obtained from Escherichia coli is able to inhibit the activity of p13(suc1)-adsorbed cyclin-dependent kinase from maize. ZmWee1 is encoded by a single gene at a locus on the long arm of chromosome 4. RNA gel blots showed the ZmWee1 transcript is about 2.4 kb in length and that its abundance reaches a maximum 15 days after pollination in endosperm tissue. High levels of expression of ZmWee1 at this stage of endosperm development imply that ZmWee1 plays a role in endoreduplication. Our results show that control of cyclin-dependent kinase activity by Wee1 is conserved among eukaryotes, from fungi to animals and plants.
Spill-in counts in the quantification of 18F-florbetapir on Aβ-negative subjects: the effect of including white matter in the reference region (2019)

There is a high correlation between WM uptake and the measured SUVR due to spill-in effect, and that this effect is reduced when including WM in the reference region. We also evaluated the performance of PVC, and we proposed an analytical correction that can be applied to preprocessed data.
A Memetic Algorithm Based PVT Variation-Aware Robust Transistor Sizing Scheme for Power-Delay Optimal Digital Standard Cell Design (2019)

Higher yield, climbing transistor counts and shrinking dimensions of a single Integrated Circuit (IC) have always been the demands in the fabrication market. However, this increased complexity and miniaturization of transistors present a challenge, due to high critical process variations combined with a ubiquitous presence of temperature and supply voltage variations, to achieve the required specification bounds on the desired performance of the circuits. Since optimization has become a very crucial task in IC design, the paper presents an efficient transistor sizing based optimization technique of the CMOS circuits to achieve low power, high performance and high yield design goals. The proposed memetic algorithm judiciously utilizes a threshold based local search procedure to improve convergence in its inherent genetic nature. The algorithm optimizes with the effect of temperature [-55 to 125]°C and supply voltage ±10% variations and in addition a number of statistically sampled sets generated as Gaussian, Latin Hypercube and Correlation Screened schemes of process variations. The proposed technique is applicable to any technology node and has been tested over several standard single-stage and some complex multi-stage digital circuits designed using a Multi-Gate high-K dielectric (MGK) 22nm CMOS model. The reduction in leakage power with propagation delay goes as high as 53% with 9% respectively, as observed across the various digital circuits.
Tribological performance of ionised vegetable oils as lubricity and fatty oiliness additives in lubricants and fuels (2009)

Abstract Lubricity and fatty oiliness additives, also known as friction modifiers in the tribological vocabulary, are steadily gaining acceptance from lubrication engineers and lubricant formulators. The present communication describes how such additives function in various tribosystems and which parameters control lubricity of finished formulations. Extensive experimental data are presented to demonstrate the outstanding tribological performance of bio‐based lubricity and fatty oiliness additives produced by Elektrionization TM of vegetable feedstocks. Featuring a unique combination of viscosity and polarity, ionised vegetable oils form sufficiently thick and resilient protective layers by adsorption to rubbing surfaces. It is shown that, unlike extreme pressure additives, which act when a direct asperity–asperity contact occurs in the boundary lubrication regime, ionised vegetable oils function by postponing the onset of the boundary lubrication regime. Copyright © 2009 John Wiley &amp; Sons, Ltd.
ChemInform Abstract: Controlled Electroplating Through Gelatin Films. (1986)

Abstract A new process for generating three dimensional surface features and contours by electroplating metals through a permeable gelatin film of variable thickness is described.
Coagulation effects of in vitro serial haemodilution with a balanced electrolyte hetastarch solution compared with a saline‐based hetastarch solution and lactated Ringer's solution* (2002)

The hydroxyethyl starches are a group of compounds that has been associated with impairment of coagulation when large volumes are administered. The thrombelastograph is commonly used to assess point-of-care whole blood coagulation. Little is known about the dose-response relationships of haemodilution, and it is reasonable to assume that a linear association exists. This may not be the case with altered electrolyte compositions of the fluids used for haemodilution. We have therefore conducted an in vitro study of haemodilution of human whole blood using lactated Ringer's solution and two high molecular weight hetastarches, one in a balanced salt solution, the other in a 0.9% saline solution. The thrombelastograph, commonly used for the assessment of the coagulation effects of synthetic colloids, was used as the coagulation assessment device. Serial haemodilution with hetastarch in a balanced salt solution demonstrated a biphasic response (of r-times and k-times, as well as alpha angles), with haemodilution in the 20-40% range causing enhanced coagulation, and higher degrees of dilution causing a decrease in overall coagulation performance. A similar picture was observed with lactated Ringer's solution, but only significantly so in alpha angles. Hetastarch in saline did not display this initial increased coagulability at mild to moderate dilutions. This biphasic response of lactated Ringer's solution and hetastarch in a balanced salt solution reflects the complex interaction of fluids and the coagulation system, and that these effects cannot be attributed to simple haemodilution. On the other hand, there was a linear decrease in maximum amplitude with haemodilution. Maximum amplitude was particularly affected by both starches, which is an expected finding in view of the known interaction between the hydroxyethyl starches and von Willebrand's factor.
Low-Impact Profiling of Streaming, Heterogeneous Applications (2011)

Computer engineers are continually faced with the task of translating improvements in fabrication process technology: i.e., Moore's Law) into architectures that allow computer scientists to accelerate application performance. As feature-size continues to shrink, architects of commodity processors are designing increasingly more cores on a chip. While additional cores can operate independently with some tasks: e.g. the OS and user tasks), many applications see little to no improvement from adding more processor cores alone. For many applications, heterogeneous systems offer a path toward higher performance. Significant performance and power gains have been realized by combining specialized processors: e.g., Field-Programmable Gate Arrays, Graphics Processing Units) with general purpose multi-core processors. Heterogeneous applications need to be programmed differently than traditional software. One approach, stream processing, fits these systems particularly well because of the segmented memories and explicit expression of parallelism. Unfortunately, debugging and performance tools that support streaming, heterogeneous applications do not exist. This dissertation presents TimeTrial, a performance measurement system that enables performance optimization of streaming applications by profiling the application deployed on a heterogeneous system. TimeTrial performs low-impact measurements by dedicating computing resources to monitoring and by aggressively compressing performance traces into statistical summaries guided by user specification of the performance queries of interest.
Unprecedented polylactide-based copolymer matrix composites by Resin Transfer Molding (2022)

International audience
Seeing into the past: creating a 3D modeling pipeline for archaeological visualization (2004)

Archaeology is a destructive process in which accurate and detailed recording of a site is imperative. As a site is exposed, documentation is required in order to recreate and understand the site in context. We have developed a 3D modeling pipeline that can assist archaeologists in the documentation effort by building rich, geometrically and photometrically accurate 3D models of the site. The modeling effort begins with data acquisition (images, range scans, GIS data, and video) and ends with the use of a sophisticated visualization tool that can be used by researchers to explore and understand the site. The pipeline includes new methods for shadow-based registration of 2D images and temporal change detection. Our multimodal augmented reality system allows users wearing head-tracked, see-through, head-worn displays to visualize the site model and associated archaeological artifacts, and to interact with them using speech and gesture.
The role of database technology in workflow management systems (panel position paper) (2002)

The main goal is to discuss the role of database technology and research in the new area of workflow management systems. There are several hundred workflow products in the market and the database community has so far had very little impact in this area. Yet, the problems faced by workflow systems have a lot in common with problems which have already been solved for databases. The paper aims to identify which database technology is relevant in the workflow area and research directions that are most likely to have a significant impact on the evolution of workflow systems. As the basis for discussion, this proposal outlines the current state of the art and points out possible areas in which database technology could be applied in workflow contexts.
Organic–Inorganic Nanospheres with Responsive Molecular Gates for Drug Storage and Release (2009)

Einfangen und freilassen: Verbrückte Silsesquioxane dienen als organisch-anorganische Vorstufen für Nanokugeln zum Einkapseln von bioaktiven Molekülen für Wirkstoff-Freisetzungen. Die Nanosysteme (siehe Bild) bestehen aus einem liposomalen Kern, der die bioaktiven Moleküle enthält, und einer Netzwerkschale aus Siliciumoxid- und organischen Esterfragmenten, die als steuerbare molekulare Tore fungieren können. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Synchronous Dynamic In-Vivo Deformation of the Mitral Valve Leaflet and Annulus (2009)

Improvements in mitral valve (MV) treatments are dependent on a complete understanding of the function, mechanical properties, and underlying mechanobiological responses of the MV. While finite element analyses have provided insight into the cooperative interactions of MV components [1], a lack of quantitative information on the dynamic MV boundary conditions and synchronous leaflet deformation limits present modeling efforts [2]. In this work, we utilized high fidelity transducers implanted in the ovine MV annulus and anterior leaflet to quantify the complete 3D MV kinematics in synchrony. Additionally, effects of systolic blood pressure (SBP) variations on annular and leaflet deformation were investigated.
Portfolio (2011)

In this demonstration, we present a code search system called Portfolio that retrieves and visualizes relevant functions and their usages. We will show how chains of relevant functions and their usages can be visualized to users in response to their queries.
N‐Palmitoyl‐4‐Hydroxy‐L‐Proline Palmityl Ester: A Pseudoceramide that Provides Efficient Skin Barrier Repair and Protection (2006)

Ceramides are the main constituents of the epidermal permeability barrier, and it has been demonstrated that the application of ceramide enriched creams promotes epidermal barrier repair. However, nature‐identical ceramides are extremely expensive and difficult to formulate. We therefore developed a new pseudoceramide, N‐palmitoyl‐4‐hydroxy‐ l ‐proline palmityl ester (BIO391). Due to its low melting point of £60°C the pseudoceramide BIO391 can easily be incorporated into cosmetic formulations. In addition, it is very safe for use in cosmetics. The efficacy of the pseudoceramide BIO391 was investigated in vivo in a model for detergent‐induced barrier disruption. Trans‐epidermal water loss, redness, and skin hydration were recorded before and after barrier disruption as well as during the subsequent 9‐day treatment with the test products. Barrier repair of skin treated with the pseudoceramide BIO391 was accomplished earlier than that of untreated and vehicle treated skin. Optimum barrier repair was achieved with 1.0% pseudoceramide BIO391 and optimum erythema reduction with 0.5% pseudoceramide BIO391. The optimum dosage could be reduced to 0.1% pseudo‐ceramide by synergistic combination with 0.1% (‐)‐a‐bisabolol. In addition, the pseudoceramide BIO391 proved to be as effective as nature‐identical ceramides 2 and 3. In summary, N‐palmitoyl‐4‐hydroxy‐ l ‐proline palmityl ester is a highly efficient barrier repair agent with efficacy equivalent to that of nature‐identical ceramides, and it has excellent formulation properties.
Difference image extrapolation for spectral completion in inter-sequence error concealment (2011)

Mobile reception of digital TV often suffers from lost blocks and slices due to suboptimal channels. Inter-sequence error concealment reconstructs lost image blocks of distorted high-resolution TV signals by inserting corresponding error-free blocks of low-resolution reference signals. It is well-suited for automotive multi-broadcast receivers and can outperform state-of-the-art methods by up to 15 dB PSNR. In this contribution, a novel spectral completion scheme is proposed which robustly estimates missing spatial frequencies of reconstructed blocks by extrapolation of difference images. Simulation results show that the proposed scheme can increase the re construction quality of inter-sequence error concealment by up to 3.2 dB. Also, the subjective quality is enhanced by significantly reducing blurring artifacts.
Telomerase activity in high‐grade cervical lesions is associated with allelic imbalance at 6Q14–22 (2003)

Our study attempts to establish the relationship between telomerase activity and allelic imbalance (AI) on chromosomes 3p and 6 in high-risk HPV-containing cervical lesions. These chromosomes were implicated previously in telomerase regulation in HPV containing immortalized cells and cervical cancer cells. Allelotyping and telomerase analysis were carried out on 28 high-grade cervical lesions (CIN III: n = 20; cervical carcinomas: n = 8), using 23 microsatellite markers on 3p, 6p and 6q. Clear telomerase activity was found in 17 of 28 lesions (61%). Allelic imbalance frequency at 6q14-22 was significantly higher in lesions with detectable telomerase activity, compared to lesions without telomerase activity (p = 0.02). No association was found between telomerase activity and AI at any of the remaining regions studied on 3p and chromosome 6. In addition, in telomerase positive passages of the HPV 16 immortalized cell line FK16A, shown recently to be responsive to chromosome 6 mediated telomerase repression, AI was found in the overlapping region of 6q14-27. These data suggest that 6q14-22 may contain 1 or more genes involved in telomerase deregulation and immortalization during cervical carcinogenesis.
Factors Supporting Intrathecal Humoral Responses following Viral Encephalomyelitis (2010)

Central nervous system (CNS) infections and autoimmune inflammatory disorders are often associated with retention of antibody-secreting cells (ASC). Although beneficial or detrimental contributions of ASC to CNS diseases remain to be defined, virus-specific ASC are crucial in controlling persistent CNS infection following coronavirus-induced encephalomyelitis. This report characterizes expression kinetics of factors associated with ASC homing, differentiation, and survival in the spinal cord, the prominent site of coronavirus persistence. Infection induced a vast, gamma interferon (IFN-γ)-dependent, prolonged increase in chemokine (C-X-C motif) ligand 9 (CXCL9), CXCL10, and CXCL11 mRNA, supporting a role for chemokine (C-X-C motif) receptor 3 (CXCR3)-mediated ASC recruitment. Similarly, CD4 T cell-secreted interleukin-21, a critical regulator of both peripheral activated B cells and CD8 T cells, was sustained during viral persistence. The ASC survival factors B cell-activating factor of the tumor necrosis factor (TNF) family (BAFF) and a proliferating-inducing ligand (APRIL) were also significantly elevated in the infected CNS, albeit delayed relative to the chemokines. Unlike IFN-γ-dependent BAFF upregulation, APRIL induction was IFN-γ independent. Moreover, both APRIL and BAFF were predominantly localized to astrocytes. Last, the expression kinetics of the APRIL and BAFF receptors coincided with CNS accumulation of ASC. Therefore, the factors associated with ASC migration, differentiation, and survival are all induced during acute viral encephalomyelitis, prior to ASC accumulation in the CNS. Importantly, the CNS expression kinetics implicate rapid establishment, and subsequent maintenance, of an environment capable of supporting differentiation and survival of protective antiviral ASC, recruited as plasmablasts from lymphoid organs.
When RASSF1A RAN into tumor suppression: Ran GTPase is a RASSF1A effector involved in controlling microtubule organization (2009)

Comment on: Dallol A, et al. Curr Biol 2009; 19:1227-32.
Conotoxin Φ‐MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti‐Apoptotic Activity (2017)

Abstract Conotoxins are a large family of disulfide‐rich peptides that contain unique cysteine frameworks that target a broad range of ion channels and receptors. We recently discovered the 33‐residue conotoxin Φ‐MiXXVIIA from Conus miles with a novel cysteine framework comprising three consecutive cysteine residues and four disulfide bonds. Regioselective chemical synthesis helped decipher the disulfide bond connectivity and the structure of Φ‐MiXXVIIA was determined by NMR spectroscopy. The 3D structure displays a unique topology containing two β‐hairpins that resemble the N‐terminal domain of granulin. Similar to granulin, Φ‐MiXXVIIA promotes cell proliferation (EC 50 17.85 μ m ) while inhibiting apoptosis (EC 50 2.2 μ m ). Additional framework XXVII sequences were discovered with homologous signal peptides that define the new conotoxin superfamily G2. The novel structure and biological activity of Φ‐MiXXVIIA expands the repertoire of disulfide‐rich conotoxins that recognize mammalian receptors.
A General Easy-to-Use Expression for Uncertainty Evaluation in Residual Voltage Measurement (2019)

This paper addresses one of the new and most important issues arising when low-power voltage transformers (LPVTs) are used in power network substations for evaluating, among others, the residual voltage measurement. Conversely to open-triangle inductive instrument transformers, the use of phase voltage transformers for measuring the residual voltage gets challenging due to the very high accuracy required for the three LPVTs. In this paper, a general expression to estimate the residual voltage measurement uncertainty, starting from the LPVTs accuracy, is presented. The effectiveness of the proposed approach is then confirmed with both Monte Carlo simulations and actual measurements on a general three-phase system.
Suppl Figure 2 from PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy (2023)

&lt;p&gt;Suppl Figure 2. AR binds to PLZF locus and regulates its gene expression&lt;/p&gt;