gebhart/patrepeval huggingface dataset:
The Epidermal Growth Factor Receptor Pathway: A Model for Targeted Therapy (2008)

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase receptor that is frequently expressed in epithelial tumors. The EGFR was the first receptor to be proposed as a target for cancer therapy, and after 2 decades of intensive research, there are several anti-EGFR agents available in the clinic. Recent advances in our understanding in the mechanisms of receptor activation and function, discovery of primary and secondary EGFR somatic mutations, as well as a new generation of anti-EGFR agents provide new leads on the clinical targeting of this receptor and may serve as a model for strategies aimed at targeting other receptors.
MD Effects of Silicone Oil Removal on CMV (2000)

info:eu-repo/semantics/nonPublished
Capacity of MIMO systems with antenna selection (2002)

We consider the capacity of multiple-input-multiple-output (MIMO) systems with reduced complexity. One link end uses all available antennas, while the other chooses the "best" L out of N antennas. As "best", we use those antennas that maximize capacity. We derive an upper bound on the capacity that can be expressed as the sum of the logarithms of ordered chi-squared variables. This bound is then evaluated analytically, and compared to results from Monte Carlo simulations. As long as L is at least as large as the number of antennas at the other link end, the achieved capacity is close to the capacity of a full-complexity system. We demonstrate, for example, that for L=3, N=8 at the receiver, and 3 antennas at the transmitter, the capacity of the reduced-complexity scheme is 20 bits/s/Hz compared to 23 bits/s/Hz of a full-complexity scheme.
TheInfluence of Extruded Feed with a high Protein Level Upon the Bioproductive Performances Obtained on the Rainbow Trout Females (Oncorhynchus mykiss) (2016)

The succes ofartificial reproduction in the rainbow trout(Oncorhynchus mykiss), the development of gonads and the results obtained at incubation are significantly affected by the feeding of the breeders. The use of quality sexual products is decisive for the assurance of the production of viable larvae and further of the estimated fish production, so that in addition to the assurance of optimal environmental parameters, the proper feeding of the breeders is required. Starting from the current stage of knowledge in the field,the main objective of the working paperwas to highlight the way the differentiatedfeeding of the rainbow trout females (Oncorhynchus mykiss) influences their growth and development. The extruded peeled feed with a high protein level upon theegg weightand the gonosomatic index were followed. The extruded peeled feed with 53% protein proved to be highly effective, materialized trough high growth performances, a better conversion and the growth of gonadal weight.
Three-part Head-splitting Proximal Humerus Fracture Through a Unicameral Bone Cyst (2012)

Unicameral bone cysts are rare in adults and are most often found incidentally on radiographs. However, they can persist from the adolescent period and may be present in locations that predispose to or exacerbate fractures.This article describes a case of a healthy 40-year-old woman who sustained a proximal humerus trauma that involved a large unicameral bone cyst, resulting in a 3-part head-splitting fracture. The epiphyseal location of the cyst contributed to the severity and extent of the fracture that resulted from a simple fall. Given the age of the patient, open reduction and internal fixation with a locking plate and lag screws was performed. The patient chose open reduction and internal fixation to preserve a hemiarthroplasty procedure in case of future revision. Successful humeral head reconstruction was achieved, and the patient fully recovered. One year postoperatively, the patient underwent arthroscopic debridement to alleviate subjective stiffness and decreased range of motion.Multipart head-splitting fractures require complex repair strategies. The gold standard for the treatment of these injuries is hemiarthroplasty. However, the decision process is difficult in a young patient given the average survival of autoplastic prostheses and the added difficulty of later revision. The current case demonstrates the complexity of decision making resulting from a rare injury in a young, healthy patient and shows that open reduction and internal fixation can provide acceptable reconstruction in such situations.
Polymer-Based Photocatalytic Hydrogen Generation (2012)

The study of the complex interfaces between organic semiconductors and liquids have recently gained increasing attention due to their interesting applications as biosensors in biological environments, in photovoltaics, and in bioinspired light-harvesting systems. Here, we report a detailed characterization of the interface between polymer films and electrolytic solutions, both by photocurrent spectroscopy and electrochemical measurements. In particular, we demonstrate that a photocatalytic semi-water splitting reaction, leading to hydrogen evolution, occurs at the polymer surface, directly contacted to an aqueous saline (NaCl) solution, as a consequence of visible-light generated photocurrent. We propose here a fully unexplored application of organic systems, i.e. the development of fuel cells: our results pave the way to the exploitation of organic polymers, seawater and solar energy as the sole raw materials for completely clean, sustainable, and economical hydrogen production.
Japanese subject subpopulation analysis of B-LONG: a Phase 3 study of long-acting recombinant factor IX Fc fusion protein (2015)

The multinational Phase 3 B-LONG study demonstrated the prolonged half-life of recombinant factor IX Fc fusion protein (rFIXFc) versus native recombinant factor IX (rFIX), and the safety and efficacy of rFIXFc for treatment of bleeding and routine prophylaxis in subjects with hemophilia B. This post hoc subgroup analysis of B-LONG evaluated the safety, efficacy, and pharmacokinetics of rFIXFc in Japanese subjects. Previously treated males with moderately severe to severe hemophilia B (endogenous FIX ≤2 IU/dL) received weekly prophylaxis (starting at 50 IU/kg/week, with dose adjustment), individualized interval prophylaxis (starting at 100 IU/kg every 10 days, with interval adjustment), episodic treatment, or perioperative management with rFIXFc. Primary endpoints were annualized bleeding rates (ABRs) and safety. rFIXFc pharmacokinetics were comparable between Japanese subjects (n=6) and non-Japanese subjects. Median ABRs for Japanese subjects in the weekly prophylaxis (n=4) and individualized interval prophylaxis (n=2) groups were 3.27 and 4.28, respectively, which were within the range for non-Japanese subjects. For Japanese subjects, most (95.8%) bleeding episodes were resolved with 1 or 2 rFIXFc infusions, and no treatment-related adverse events or inhibitors were observed. rFIXFc was safe and efficacious for prophylaxis and treatment of bleeding in Japanese subjects with outcomes and pharmacokinetics comparable to non-Japanese subjects.
RelB Is Differentially Regulated by IκB Kinase-α in B Cells and Mouse Lung by Cigarette Smoke (2008)

The activation of transcription factor NF-kappaB is controlled by two main pathways: the classical canonical (RelA/p65-p50)- and the alternative noncanonical (RelB/p52)-NF-kappaB pathways. RelB has been shown to play a protective role in RelA/p65-mediated proinflammatory cytokine release in immune-inflammatory lymphoid cells. Increased infiltration of macrophages and lymphoid cells occurs in lungs of patients with chronic obstructive pulmonary disease, leading to abnormal inflammation. We hypothesized that RelB, and its signaling pathway, is differentially regulated in macrophages and B cells and in lung cells, leading to differential regulation of proinflammatory cytokines in response to cigarette smoke (CS). CS exposure increased the levels of RelB and NF-kappaB-inducing kinase associated with recruitment of RelB on promoters of the IL-6 and macrophage inflammatory protein-2 genes in mouse lung. Treatment of macrophage cell line, MonoMac6, with CS extract showed activation of RelB. In contrast, RelB was degraded by a proteasome-dependent mechanism in B lymphocytes (human Ramos, mouse WEHI-231, and primary mouse spleen B cells), suggesting that RelB is differentially regulated in lung inflammatory and lymphoid cells in response to CS exposure. Transient transfection of dominant negative IkappaB-kinase-alpha and double mutants of NF-kappaB-inducing kinase partially attenuated the CS extract-mediated loss of RelB in B cells and normalized the increased RelB level in macrophages. Taken together, these data suggest that RelB is differentially regulated in response to CS exposure in macrophages, B cells, and in lung cells by IkappaB-kinase-alpha-dependent mechanism. Rapid degradation of RelB signals for RelA/p65 activation and loss of its protective ability to suppress the proinflammatory cytokine release in lymphoid B cells.
An electron spin resonance investigation of the products of the Friedel–Crafts reaction of sulphur dioxide with methylnaphthalenes (1986)

A series of mono-, di-, tri-, tetra-, and hexa-methylnaphthalenes, and naphthalene were reacted with AlCl3–SO2, AlCl3–SOCl2, or AlCl3–S2Cl2, using CH2Cl2 as solvent. The radical cation products produced were studied using e.s.r. 1,4-, 1,5-, and 1,8-dimethyl-, 1,2,4-trimethyl-, 1,2,3,4- and 1,3,5,7-tetramethyl-, 1,2,3,4,5,8-hexamethyl-, and octamethyl-naphthalene all gave predominantly spectra from the monomer cation radical. Naphthalene, 1- and 2-methyl- and 1,3-, 1,6-, 1,7-, 2,3-, 2,6-, and 2,7-dimethylnaphthalene gave predominantly spectra ascribed to methyl derivatives of naphtho[1,8-cd]-1,2-dithiole. Spectra from these compounds also contained a significant component which was ascribed to methylperylenes formed from the Scholl condensation of the parent compound. A species described as 3H, 10H-acenaphtho[1,2-c]-1,2-dithiete was observed as a minor product in the reactions with 1,8-dimethylnaphthalene.
Bismuth dodecylbenzene sulfonate (Bi-ddbsa), bismuth dimethyldithiocarbamate (Bi-DTC) and dibenzyldisulphide (DBDS) tribofilms under slip-rolling vs. Mo-dttc (2017)

The frictional response of molybdenum bis(C11-14 branched and linear alkyl) carbamodithioate oxo thioxo complex (Mo-dttc) versus bismuth dimethyldithiocarbamate (Bi-dtc) and bismuth dodecylbenzene Sulfonate (Bi-ddbsa) slip-rolling under mixed/boundary lubrication (T=120°C, n=10 millions of cycles, P0max=2.25 GPa) in PAO-based formulation against three different steel alloys were compared.
In vitro fermentation of various pectin substrates by human fecal microbiota (2013)

Metabolic activity of the gut microbiota is formation of short chain fatty acids (SCFAs). SCFA contribute to human healthy by serving as an energy source for intestinal epithelial cells and inhibiting pathogenic growth by lowering pH in the intestinal lumen. The aims of this study were to assess the short chain fatty acids production of various pectin samples (High Methoxy Pectin (HMP), Sugar Beet Pectin (SBP), and Soy pectin (SOY)) and to determine the composition of gut microbiota. Fructooligosaccharide (FOS, known prebiotic) was used as a control. Fresh feces were collected from 4 healthy men and incubated anaerobically with various substrates at 37°C. Culture aliquots were taken at 0, 6, 12, 24, and 30 h. SCFAs were measured by GC. FOS resulted in higher butyrate production and decreased the production of acetate compared with other pectin treatments ( P &lt;0.05). Compared with other treatments, incubation with SOY showed significantly greater propionate production ( P &lt;0.05). Denaturing gradient gel electrophoresis (DGGE) fingerprint analysis showed a distinct profile of fecal microbiota with different samples. The findings indicate that consuming different types of pectin substrates might affect fecal microbiota composition and enhance the production of SCFAs. Funding provided by Arkansas Soybean Promotion Board is greatly appreciated.
ELoRa: End-to-end Emulation of Massive IoT LoRaWAN Infrastructures (2023)

In this paper, we present ELoRa, an emulation tool that generates Long Range Wide Area Network (LoRaWAN) traffic for an arbitrary number of LoRa devices and in an end-to-end virtualized LoRaWAN setting. Using ns-3, we improve an existing radio access network simulator to produce traffic compatible with ChirpStack, an open-source, cloud-native, LoRaWAN network functions stack. Our tool can be used to create realistic traffic and anomalies in order to test orchestration techniques on a real, distributed infrastructure. Moreover, the LoRaWAN core network functions (bridges, network server) are agnostic to the simulation of the radio access and can change parameters of simulated devices using native LoRaWAN protocol primitives, therefore enabling live-testing of resource allocation techniques to manage the radio access network. Multiple ELoRa instances can be connected to the same LoRaWAN core, each instance being able to support 50000 devices and 7 gateways.
Long-term safety and efficacy of emicizumab in a phase 1/2 study in patients with hemophilia A with or without inhibitors (2017)

Emicizumab (ACE910), a recombinant humanized bispecific monoclonal antibody, provides factor VIII (FVIII) cofactor bridging function to restore hemostasis in people with hemophilia A. In a phase 1 trial involving 18 Japanese patients with severe hemophilia A, once-weekly subcutaneous administration of emicizumab 0.3, 1, or 3 mg/kg (cohorts 1, 2, and 3, respectively) was well tolerated and substantially reduced annualized bleeding rates (ABRs) in the presence or absence of FVIII inhibitors. The current study represents an open-label, long-term extension of the previously reported 12-week phase 1 study, in which 16 of 18 patients continued to receive emicizumab for up to 33.3 months. Long-term emicizumab treatment was well tolerated, with no thromboembolic events reported and no neutralizing antiemicizumab antibodies developing during the course of the study. Plasma concentrations of emicizumab increased in a dose-proportional manner, with activated partial thromboplastin times remaining short. In cohorts 1, 2, and 3, respectively, median ABRs remained low at 1.4, 0.2, and 0 compared with 4.4, 0, and 0 in the 12-week study. Overall, 8 patients experienced no bleeding events (6 patients with and 2 patients without FVIII inhibitors); dose up-titration resulted in further reduction in ABRs in patients with suboptimal bleeding control; and the episodic use of clotting factors to control bleeding was reduced. In conclusion, long-term emicizumab treatment demonstrated a favorable safety profile with encouraging efficacy, irrespective of the presence of FVIII inhibitors, in patients with hemophilia A. This study was registered at www.clinicaltrials.jp as #JapicCTI-132195.
Three-dimensional Poole-Frenkel analytical model for carrier transport in amorphous chalcogenides (2013)

In this work, we propose a three-dimensional Poole-Frenkel (3DPF) analytical model for carrier transport in amorphous chalcogenides. 3DPF is based on the original Poole-Frenkel (PF) theory of non-interacting Coulombic traps responsible for carrier conduction in the bulk of the material. However, while in the original PF equation the device current-voltage characteristics is calculated by considering the barrier-lowering on the applied electric field direction only, in 3DPF we overcome this approximation by calculating the electronic current due to the integral effect of the Coulombic barrier shaping in three dimensions upon application of an electric field. As a consequence, 3DPF is capable to describe both the relatively-low and relatively-high electric fields regimes, while the PF equation implicitly assumes the device to be operated at high electric fields only. Thus, 3DPF features a better agreement with experimental data compared to original PF, predicting both (i) Poole-like behavior at low-fields, i.e., I∝sinh(V), and (ii) PF-like dependence in the higher fields regime, i.e., I∝exp(V), within a single coherent physical picture. The model is validated through I–V characterization on phase-change memory devices integrating amorphous Ge2Sb2Te5 as active material. Moreover, to address the model consistency, temperature dependence and correlations between model parameters are validated in comparison with experimental data.
IN VIVO MECHANISMS OF TRANSPLANTATION TOLERANCE BY SIGNAL ONE BLOCKADE WITH α-CD45RB: ROLE OF CTLA4 NEGATIVE T CELL COSTIMULATORY PATHWAY. (2000)

Fecteau, Scott1; Ariyan, Charlotte1; Freitas, Alexandre1; Halpern, Liza1; Sayegh, Mohamed2; Basadonna, Giacomo1; Rothstein, David1 Author Information
Poly(Hydroxybutyrate-co-9% Hydroxyvalerate) Film Surface Modification by Ar, O2, H2,O/O2, H2O, and H2O2Plasma Treatment (1997)

Abstract We modified poly(hydroxybutyrate-co-9% hydroxyvalerate) film surfaces with Ar, O2, H2O/O2, H2O, and H2O2 vapor plasma treatments. We measured the grafted oxygen concentration by XPS analyses and the wettability by a θH2O contact angle method. Comparison between these various plasma treatments seems to indicate a better surface wettability correlated to C-OH bonds obtained with H2O and H2O2 plasma than with Ar and O2 plasma which incorporate oxygen atoms in C˭O bonds more easily.
Optimizing TLB entries for mixed page size storage in contiguous memory (2023)

A system and method for accessing memory are provided. The system comprises a lookup buffer for storing one or more page table entries, wherein each of the one or more page table entries comprises at least a virtual page number and a physical page number; a logic circuit for receiving a virtual address from said processor, said logic circuit for matching the virtual address to the virtual page number in one of the page table entries to select the physical page number in the same page table entry, said page table entry having one or more bits set to exclude a memory range from a page.
Data from Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti–PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma (2023)

&lt;div&gt;Abstract&lt;p&gt;Cancer immunotherapy combinations have recently been shown to improve the overall survival of advanced mesotheliomas, especially for patients responding to those treatments. We aimed to characterize the biological correlates of malignant pleural mesotheliomas’ primary resistance to immunotherapy and antiangiogenics by testing the combination of pembrolizumab, an anti–PD-1 antibody, and nintedanib, a pan-antiangiogenic tyrosine kinase inhibitor, in the multicenter PEMBIB trial (NCT02856425). Thirty patients with advanced malignant pleural mesothelioma were treated and explored. Unexpectedly, we found that refractory patients were actively recruiting CD3&lt;sup&gt;+&lt;/sup&gt;CD8&lt;sup&gt;+&lt;/sup&gt; cytotoxic T cells in their tumors through CXCL9 tumor release upon treatment. However, these patients displayed high levels of somatic copy-number alterations in their tumors that correlated with high blood and tumor levels of IL6 and CXCL8. Those proinflammatory cytokines resulted in higher tumor secretion of VEGF and tumor enrichment in regulatory T cells. Advanced mesothelioma should further benefit from stratified combination therapies adapted to their tumor biology.&lt;/p&gt;Significance:&lt;p&gt;Sequential explorations of fresh tumor biopsies demonstrated that mesothelioma resistance to anti–PD-1 + antiangiogenics is not due to a lack of tumor T-cell infiltration but rather due to adaptive immunosuppressive pathways by tumors, involving molecules (e.g., IL6, CXCL8, VEGF, and CTLA4) that are amenable to targeted therapies.&lt;/p&gt;&lt;p&gt;&lt;a href="https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-13-4-ITI" target="_blank"&gt;This article is highlighted in the In This Issue feature, p. 799&lt;/a&gt;&lt;/p&gt;&lt;/div&gt;
Type I Interferon Signaling Is Required for Dacryoadenitis in the Nonobese Diabetic Mouse Model of Sjögren Syndrome (2018)

Nonobese diabetic (NOD) mice spontaneously develop lacrimal and salivary gland autoimmunity similar to human Sjögren syndrome. In both humans and NOD mice, the early immune response that drives T-cell infiltration into lacrimal and salivary glands is poorly understood. In NOD mice, lacrimal gland autoimmunity spontaneously occurs only in males with testosterone playing a role in promoting lacrimal gland inflammation, while female lacrimal glands are protected by regulatory T cells (Tregs). The mechanisms of this male-specific lacrimal gland autoimmunity are not known. Here, we studied the effects of Treg depletion in hormone-manipulated NOD mice and lacrimal gland gene expression to determine early signals required for lacrimal gland inflammation. While Treg-depletion was not sufficient to drive dacryoadenitis in castrated male NOD mice, chemokines (<i>Cxcl9</i>, <i>Ccl19</i>) and other potentially disease-relevant genes (<i>Epsti1</i>, <i>Ubd</i>) were upregulated in male lacrimal glands. Expression of <i>Cxcl9</i> and <i>Ccl19</i>, in particular, remained significantly upregulated in the lacrimal glands of lymphocyte-deficient NOD-severe combined immunodeficiency (SCID) mice and their expression was modulated by type I interferon signaling. Notably, <i>Ifnar1</i>-deficient NOD mice did not develop dacryoadenitis. Together these data identify disease-relevant genes upregulated in the context of male-specific dacryoadenitis and demonstrate a requisite role for type I interferon signaling in lacrimal gland autoimmunity in NOD mice.
Entity Linking and Slot Filling through Statistical Processing and Inference Rules. (2009)

Information extraction is one of the fundamentally important tasks in Natural Language Processing, and as such it has been the subject of many evaluations and competitions. The latest such evaluation, the Knowledge Base Population (KBP) part of the Text Analysis Conference 2009, is focusing on two aspects: entity linking and slot filling. This paper presents the design and implementation of the hybrid statistical/rule-based IBM system that performs these two tasks. 1
Combating Complement's Deleterious Effects on Nanomedicine by Conjugating Complement Regulatory Proteins to Nanoparticles (2021)

Complement opsonization is among the biggest challenges facing nanomedicine. Nearly instantly after injection into blood, nanoparticles are opsonized by the complement protein C3, leading to clearance by phagocytes, fouling of targeting moieties, and release of anaphylatoxins. While surface polymers such as poly(ethylene glycol) (PEG) partially decrease complement opsonization, most nanoparticles still suffer from extensive complement opsonization, especially when linked to targeting moieties. To ameliorate the deleterious effects of complement, two of mammals' natural regulators of complement activation (RCAs), Factors H and I, are here conjugated to the surface of nanoparticles. In vitro, Factor H or I conjugation to PEG-coated nanoparticles decrease their C3 opsonization, and markedly reduce nanoparticle uptake by phagocytes. In an in vivo mouse model of sepsis-induced lung injury, Factor I conjugation abrogates nanoparticle uptake by intravascular phagocytes in the lungs, allowing the blood concentration of the nanoparticle to remain elevated much longer. For nanoparticles targeted to the lung's endothelium by conjugation to anti-ICAM antibodies, Factor I conjugation shifts the cell-type distribution away from phagocytes and toward endothelial cells. Finally, Factor I conjugation abrogates the severe anaphylactoid responses common to many nanoparticles, preventing systemic capillary leak and preserving blood flow to visceral organs and the brain. Thus, conjugation of RCAs, like Factor I, to nanoparticles is likely to help in nanomedicine's long battle against complement, improving several key parameters critical for clinical success.