gebhart/patrepeval huggingface dataset:
Preliminary communication: matrix metalloproteinases in Kaposi's sarcoma (2003)

Journal Article Preliminary communication: matrix metalloproteinases in Kaposi's sarcoma Get access U. Impola, U. Impola Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar M.A. Cuccuru, M.A. Cuccuru Istituto di Dermatologia, Università degli Studi di Sassari, Sassari, Italy Search for other works by this author on: Oxford Academic Google Scholar M.V. Masala, M.V. Masala Istituto di Dermatologia, Università degli Studi di Sassari, Sassari, Italy Search for other works by this author on: Oxford Academic Google Scholar L. Jeskanen, L. Jeskanen Pathology, Helsinki University Central Hospital, Meilahdentie 2, 00250 Helsinki, Finland Search for other works by this author on: Oxford Academic Google Scholar F. Cottoni, F. Cottoni Istituto di Dermatologia, Università degli Studi di Sassari, Sassari, Italy Search for other works by this author on: Oxford Academic Google Scholar U. Saarialho‐Kere U. Saarialho‐Kere Departments of DermatologyClinical Research Centre, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden Ulpu Saarialho‐Kere, E‐mail: ulpu.saarialho‐kere@helsinki.fi Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 4, 1 October 2003, Pages 905–907, https://doi.org/10.1046/j.1365-2133.2003.05561.x Published: 01 October 2003
Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension (2021)

This study uncovers PAH-induced EC transcriptomic changes at a high resolution, revealing novel targets for potential therapeutic candidate development.
Wideband wavelength tunable modelocked fibrelaser over 1557 – 1607 nm (2000)

An electronically wavelength tunable modelocked fibre laser operating over a 50 nm range using an all-fibre acousto-optic tunable filter is presented. The tuning range is 1557 – 1607 nm, for a 70 m long erbium-doped fibre (EDF) with a 270 ppm concentration.
Biological process architecture in continuous‐flow activated sludge by gravimetry: Controlling densified biomass form and function in a hybrid granule–floc process at Dijon WRRF, France (2021)

Full-scale demonstration of activated sludge conversion into a granule-floc hybrid process was implemented in Dijon (France) water resource recovery facility (WRRF). Biomass densification was achieved based on external gravimetric selection using hydrocyclones within continuous-flow anaerobic-anoxic-oxic (A<sup>2</sup> O) biological nutrient removal (BNR) bioreactor. The goal was to optimize settleability of biological sludge by lowering and stabilizing sludge volume index (SVI) to improve process robustness and resiliency. Process proved to stabilize operation and to uncouple the total solids residence time (SRT) between floc and granule morphologies. The densified biomass initially produced stable SVI < 100 ml/g for a period of 4 months and thereafter a steady state year-round SVI below 50 ml/g, including the winter period during which the control train SVI expansion >200 ml/g. The densified biomass successfully broke the vicious cycle of interannual bulking. Form and function interrelationship is proposed for the densified biomass (hybrid floc-granule). The concept of biological architecture is proposed as the purposeful control of granule and floc proportions, with a proposed "form factor" ratio of 1:2 granule to floc, that produce a "SRT uncoupling function factor" ratio of 4:1 granule to floc, further resulting in very stable settling and effluent functionalities. PRACTITIONER POINTS: Controlling granule-floc proportions allows for sludge volume index (SVI) operational adjustment, which further allows for increased clarified design accuracy. One-third aggregates dramatically improved settling characteristics: 20% and 35% of AGS ensures SVIs below 100 and 50 ml/g, respectively. Densified biomass enables new SRT and clarifier flux rates approaches for engineering and operation practices: Doubling typical surface loading rates from 6.0-8.5 to 15-20 kg m<sup>-2</sup> h<sup>-1</sup> and surface overflow rates from 0.6-0.8 to 1.5-2.4 m/h SRT uncoupling of 1:4 is achieved between floc and granule, enabling specific niche environment for fast and slow growing organisms.
Angiotensin Receptor Blocker–Related Sprue-like Enteropathy: Review of Food and Drug Administration Adverse Event Reporting System (2023)

Reports to FAERS for ARB-related SE are mostly related to olmesartan. There was a steep decline in reports of olmesartan-related SE following the lawsuit with potential of lawyer interference. There are reports of SE related to ARBs other than olmesartan, with increased physician awareness and the potential to discover a class effect with future studies.
Designable peptides on graphene field-effect transistors for selective detection of odor molecules (2022)

Gas sensing based on graphene field-effect transistors (GFETs) has gained broad interest due to their high sensitivity. Further progress in gas sensing with GFETs requires to detection of various odor molecules for applications in the environmental monitoring, healthcare, food, and cosmetic industries. To develop the ubiquitous odor-sensing system, establishing an artificial sense of smell with electronic devices by mimicking olfactory receptors will be key. Although the application of olfactory receptors to GFETs is straightforward for odor sensing, synthetic molecules with a similar function to olfactory receptors would be desirable to realize the robust performance of sensing. In this work, we designed three new peptides consisting of two domains: a bio-probe to the target molecules and a molecular scaffold. These peptides were rationally designed based on a motif sequence in olfactory receptors and self-assembled into a molecular thin film on GFETs. Limonene, methyl salicylate, and menthol were employed as representative odor molecules of plant flavors to demonstrate the biosensing of odor molecules. The conductivity change of GFETs against the binding to odor molecules with various concentrations and the dynamic response revealed a distinct signature of three different peptides against individual species of the target molecules. The kinetic response of each peptide exhibited characteristic time constants in the adsorption and desorption process, also supported by the principal component analysis. Our demonstration of the graphene odor sensors with the designed peptides opens a way to establish future peptide-array sensors with multi-sequence of peptide, realizing an odor sensing system with higher selectivity.
The Possibility of a High-efficiency Wave Power Generation System using Dielectric Elastomers (2021)

Abstract: Power generation using dielectric elastomer (DE) artificial muscle is attracting attention because of its light weight, low cost, and high efficiency. Since this method is a system that produces electricity without emitting carbon dioxide nor using rare earths, it would contribute to the goal of environmental sustainability. In this paper, the background of DEs, the associated high-efficient wave energy generation (WEG) systems that we developed using DEs, as well as the latest development of its material are summarized. By covering the challenges we face and the achievements that we&amp;rsquo;ve reached, we can discuss the opportunities to build the foundation of a recycled energy society through the usage of these WEGs. On the other hand, to make these possibilities commercially successful, the advantages of DEs need to be integrated with traditional technologies. To achieve this, we also consider the method of using DEs alone and a system used in combination with an oscillating water column. Finally, the current status and future of DEGs are discussed.
Stibathiolanes: Synthesis, solid state structure, and solution behavior (1990)

The first examples of a new class of main group metallacycles, stibathiolanes, have been synthesized via transmetalation from ziconocene metallacycles. The x-ray crystal structures of three 1-halostibathionaes have been determined and the compounds found to be polymeric in the crystalline state. Physical and spectroscopic data indicate that the compounds are monomeric in hydrocarbon solution but that they undergo rapid-reversible halide-exchange reactions. A consequence of one of these exchange reactions is the inversion of stereochemistry at antimony. The processes have been investigated by using a variety of NMR and crossover experiments. The proposed intermediate for the inversion of stereochemistry at the metal center is supported by the solid-state structures of the compounds in which the proposed connectivity of the intermediate is crystallographically established.
Organic Double‐Heterostructure Photovoltaic Cells Employing Thick Tris(acetylacetonato)ruthenium(III) Exciton‐Blocking Layers (2005)

Bathocuproine (BCP) or tris(acetylacetonato)ruthenium(III) (Ru(acac)3) is used as the exciton-blocking layer (EBL) in photovoltaic cells. The difference in thickness-dependent efficiency characteristics between the blockers (see Figure) is that the Ru(acac)3 energy-level alignment allows for the transport of holes from the cathode to the C60 acceptor level, whereas BCP relies on metal-deposition-induced damage for charge transport.
Reducing the normal acceleration sensitivity of surface transverse wave resonators using micromachined isolation systems (2002)

Micromachined silicon platforms provide two methods for reducing the acceleration sensitivity of surface transverse wave resonators, First, micromachining allows precise control over the structure of the silicon mounting platform and supports. The platform can thus be shaped to apply stresses to the resonator such that the minimum acceleration sensitivity is achieved. Second, a platform supported by flexibie arms acts as a vibration isolation system, thus reducing the effective acceleration applied to the resonator. A study of a silicon micromachined isolation platform has been performed. Numerical analysis has been used to determine the effect of stress on the resonator, while a mass spring model has been used to predict the effective acceleration applied to the resonator.
Efficacy of Quinoxaline-2-Carboxylate 1,4-Di- N -Oxide Derivatives in Experimental Tuberculosis (2008)

This study extends earlier reports regarding the in vitro efficacies of the 1,4-di-N-oxide quinoxaline derivatives against Mycobacterium tuberculosis and has led to the discovery of a derivative with in vivo efficacy in the mouse model of tuberculosis. Quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives were tested in vitro against a broad panel of single-drug-resistant M. tuberculosis strains. The susceptibilities of these strains to some compounds were comparable to those of strain H(37)Rv, as indicated by the ratios of MICs for resistant and nonresistant strains, supporting the premise that 1,4-di-N-oxide quinoxaline derivatives have a novel mode of action unrelated to those of the currently used antitubercular drugs. Specific derivatives were further evaluated in a series of in vivo assays, including evaluations of the maximum tolerated doses, the levels of oral bioavailability, and the efficacies in a low-dose aerosol model of tuberculosis in mice. One compound, ethyl 7-chloro-3-methylquinoxaline-2-carboxylate 1,4-dioxide, was found to be (i) active in reducing CFU counts in both the lungs and spleens of infected mice following oral administration, (ii) active against PA-824-resistant Mycobacterium bovis, indicating that the pathway of bioreduction/activation is different from that of PA-824 (a bioreduced nitroimidazole that is in clinical trials), and (iii) very active against nonreplicating bacteria adapted to low-oxygen conditions. These data indicate that 1,4-di-N-oxide quinoxalines hold promise for the treatment of tuberculosis.
Micro X-Ray Fluorescence Spectroscopy: Selected Geochemical Applications (1968)

Comprehensive and accurate data on the relative and absolute abundances of the elements are critical to a better understanding of the principles governing their crustal distribution and migration processes. Many geochemically coherent pairs or groups of elements (e.g., the halogens and the rare earths) are difficult to determine chemically. Microanalytical methods combining chemical and x-ray fluorescence techniques have been developed not only to determine these elements rapidly and accurately, but also to provide total analyses of milligram quantities of rare geologic specimens. One of these methods (solution—dilution) is virtually free of matrix effects and is adaptable to the analysis of trace or major constituents. These methods have proven invaluable in the microdetermination of Sc, Y, and the individual rare-earth elements in minerals or rare-earth separates on as little as 1 mg of total sample. Other applications have been the determination of iron in silicates, bromine and iodine in well waters, and the total analysis of small amounts of chromium, sulfide, and carbonate minerals.
Management of less-than-severe mitral regurgitation: should guidelines recommend earlier surgical intervention?☆ (2011)

Over half of patients with chronic persistent, but sub-severe MR due to mitral leaflet prolapse develop LV dysfunction or worsening regurgitation despite optimal medical management. LV deterioration can occur even in the absence of MR progression. These data advocate for the development of detailed guidelines supporting frequent echocardiographic monitoring and the identification of earlier triggers for surgical consideration prior to the development of LV dysfunction in this patient population.
Supplementary Table 1 from Cancer-Associated Fibroblasts Induce Matrix Metalloproteinase–Mediated Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma Cells (2023)

&lt;p&gt;PDF file - 91K, PCR array gene list&lt;/p&gt;
Skeletal muscle and small‐conductance calcium‐activated potassium channels (1999)

Skeletal muscle becomes hyperexcitable following denervation and when cultured in the absence of nerve cells. In these circumstances, the bee venom peptide toxin apamin, a blocker of small-conductance calcium-activated potassium (SK) channels, dramatically reduces the hyperexcitability. In this report, we show that SK3 channels are expressed in denervated skeletal muscle and in L6 cells. Action potentials evoked from normal innervated rat skeletal muscle did not exhibit an afterhyperpolarization, indicating a lack of SK channel activity; very low levels of apamin binding sites, SK3 protein, or SK3 mRNA were present. However, denervation resulted in apamin-sensitive afterhyperpolarizations and increased apamin binding sites, SK3 protein, and SK3 mRNA. Cultured rat L6 myoblasts and differentiated L6 myotubes contained similar levels of SK3 mRNA, although apamin-sensitive SK currents and apamin binding sites were detected only following myotube differentiation. Therefore, different molecular mechanisms govern SK3 expression levels in denervated muscle compared with muscle cells differentiated in culture. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 742–750, 1999.
Silicon-integrated photonic circuit for a single-stage large-angle beam steering optical phased array (2010)

In this paper, we present the results of the design and fabrication of a 12 channel nano-membrane-based optical phased array that allows for large angle beam steering operating at wavelength=1.55&#956;m. Our device is fabricated on silicon-oninsulator using standard CMOS process. By implementing unequally spaced waveguide array elements, we can relax the half-wavelength spacing requirement for large angle beam steering, thereby avoiding the optical coupling between adjacent waveguides and reducing the side-lobe-level of the array radiation pattern. 1D beam steering of tranverseelectric polarized single mode light is designed to be achieved thermo-optically through the use of thin film metal phase shifters.
The Slice Is Served: Enforcing Radio Access Network Slicing in Virtualized 5G Systems (2019)

The notions of softwarization and virtualization of the radio access network (RAN) of next-generation (5G) wireless systems are ushering in a vision where applications and services are physically decoupled from devices and network infrastructure. This crucial aspect will ultimately enable the dynamic deployment of heterogeneous services by different network operators over the same physical infrastructure. RAN slicing is a form of 5G virtualization that allows network infrastructure owners to dynamically “slice” and “serve” their network resources (i. e., spectrum, power, antennas, among others) to different mobile virtual network operators (MVNOs), according to their current needs. Once the slicing policy (i.e., the percentage of resources assigned to each MVNO) has been computed, a major challenge is how to allocate spectrum resources to MVNOs in such a way that (i) the slicing policy defined by the network owner is enforced; and (ii) the interference among different MVNOs is minimized. In this article, we mathematically formalize the RAN slicing enforcement problem (RSEP) and demonstrate its NP-hardness. For this reason, we design three approximation algorithms that render the solution scalable as the RSEP increases in size. We extensively evaluate their performance through simulations and experiments on a testbed made up of 8 software-defined radio peripherals. Experimental results reveal that not only do our algorithms enforce the slicing policies, but can also double the total network throughput when intra-MVNO power control policies are used in conjunction.
Aeroelastic sensitivity calculations using a Newton-based full-potential equation solver (1995)

An efficient, Newton-based, sensitivity calculation method developed for Newton-based steady analysis codes is extended to an harmonic-unsteady aeroelastic solver. A single Newton system framework is used to solve: 1.) the nonlinear steady aerodynamic problem, 2 . ) the harmonic-unsteady aeroelastic eigenvalue problem, and 3.) the sensitivity calculations for both. The Full Potential equation is used to model the aerodynamic behavior, and a two degree of freedom undamped typical section is used to model the structure. Sensitivities are calculated for general shape modal design variables and the nondimensional parameters appearing in the structural equations. The unsteady code is compared to experimental results and example design perturbations using the calculated sensitivities are given for aerodynamic and aeroelastic problems.
Spectrum of ST-T–Wave Patterns and Repolarization Parameters in Congenital Long-QT Syndrome (2000)

Typical ST-T-wave patterns are present in the majority of genotyped LQTS patients and can be used to identify LQT1, LQT2, and possibly LQT3 genotypes. Family-grouped ECG analysis improves genotype identification accuracy. This approach can simplify genetic screening by targeting the gene for initial study. The multiple ST-T patterns in each genotype raise questions regarding the pathophysiology and regulation of repolarization in LQTS.
Distributed Estimation Under Sensor Attacks (2017)

This paper studies multi-agent distributed estimation under sensor attacks. Individual agents make sensor measurements of an unknown parameter belonging to a compact set, and, at every time step, a fraction of the agents' sensor measurements may fall under attack and take arbitrary values. The goal of this paper is to develop a distributed estimation algorithm to ensure that all, even those whose sensors are under attack, correctly estimate the parameter of interest. We assume a fully distributed setup; there is no fusion center and inter-agent collaboration is restricted to message exchanges between neighboring agents, the neighborhoods corresponding to a pre-specified, possibly parse, communication graph. We present two versions of the Saturated Innovation Update (SIU) algorithm for distributed estimation resilient to sensor attacks. The SIU algorithm is a consensus + innovations type estimator: agents iteratively estimate the parameter of interest by combining estimates of neighbors (consensus) and local sensing information (innovations). In the SIU algorithm, each agent applies a local, time-varying scalar gain to its innovation term to ensure that the energy of the scaled innovation lies below a threshold. Under the first version of SIU, which uses constant combination weights, if less than three tenths of agent sensors fall under attack, then, all of the agents' estimates converge exponentially fast to the true parameter. Under the second version, which uses time-decaying weights, if less than one half of the agent sensors fall under attack, then, all of the agents' estimates converge at a polynomial rate to the true parameter. We show that the resilience of SIU to sensor attacks does not depend on the topology of the inter-agent communication network, as long as it remains connected. Finally, we demonstrate the performance of SIU with numerical examples.
Iterative algorithms for estimating the capacity of automated production lines with finite buffers (1989)

SUMMARY The paper describes two fast iterative algorithms for estimating the capacity of automated production lines with finite buffers. These algorithms are based on the linear programming formulation of the problem developed earlier by the author, and provide a range of values in which the throughput of the line is expected to lie. The throughput estimates of the two algorithms, compared with an estimate based on a simple workload analysis, indicate the amount of blocking/starvation as well as the probable causes of this unproductive time. The paper illustrates how inferences can be drawn from the two algorithms and used to improve the loading sequence and lot sizes. Managers can decide if the potential for improvement, which would be to get rid of all blocking/starvation, justifies the time to be spent on such an effort. New alternatives can be developed based on the insights provided by the algorithms and tested quickly.
Joint optimization for social content delivery in wireless networks (2016)

Over the last decade, success of social networks has significantly reshaped how people consume information. Recommendation of contents based on user profiles is well-received. However, as users become increasingly mobile, little is done to consider the constraints of the wireless environment. In this paper, we investigate a centralized wireless content delivery system, aiming to optimize overall user experience given the capacity constraints of the wireless networks, by deciding what contents to deliver and how. We propose a scheduling framework incorporating content deliverability. Results indicate this novel joint optimization approach outperforms existing systems, which separates recommendation and delivery, especially when the wireless network is operating at maximum capacity.