gebhart/patrepeval huggingface dataset:
Objective assessment of postural stability in Parkinson's disease using mobile technology (2015)

The hardware within the tablet provides data of sufficient accuracy for the quantification of postural stability in patients with Parkinson's disease. The objectivity, portability, and ease of use of this device make it ideal for use in clinical environments lacking sophisticated biomechanical systems.
ChemInform Abstract: Synthesis of 10,11‐Didehydro Cinchona Alkaloids and Key Derivatives. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The use of microarrays in medicine. (2001)

The completion of the human genome project marks a major leap in our understanding of biological processes that will eventually transform all medical sciences. In a recent review in this journal, Ben Asher et al. [1] described the Israeli perspective of the human genome project, including microarray technology. In the present review, we will provide an overview of the application of microarray technology in research relevant to human disease.
HybridAlpha: An Efficient Approach for Privacy-Preserving Federated Learning (2019)

Federated learning has emerged as a promising approach for collaborative and privacy-preserving learning. Participants in a federated learning process cooperatively train a model by exchanging model parameters instead of the actual training data, which they might want to keep private. However, parameter interaction and the resulting model still might disclose information about the training data used. To address these privacy concerns, several approaches have been proposed based on differential privacy and secure multiparty computation (SMC), among others. They often result in large communication overhead and slow training time. In this paper, we propose HybridAlpha, an approach for privacy-preserving federated learning employing an SMC protocol based on functional encryption. This protocol is simple, efficient and resilient to participants dropping out. We evaluate our approach regarding the training time and data volume exchanged using a federated learning process to train a CNN on the MNIST data set. Evaluation against existing crypto-based SMC solutions shows that HybridAlpha can reduce the training time by 68% and data transfer volume by 92% on average while providing the same model performance and privacy guarantees as the existing solutions.
Evolutionary multi-objective optimization of robustness and innovation in redundant genetic representations (2009)

Robustness and innovation are two essential facets for biological evolution, where robustness means the relative insensitivity of an organism's phenotype to mutations, while innovation (evolvability) denotes the individual's ability to evolve novel phenotypes that help its survival and reproduction. Although much research has been conducted on robustness and evolvability of both biological and computational evolutionary systems, little work on the quantitative analysis of the relationship between robustness and evolvability has been reported. In this work, a measure for innovation called local variability has been suggested. Based on a neutrality degree borrowed from literature [1] and local variability, a multi-objective evolutionary algorithm has been employed to maximize the robustness and innovation by optimizing the genotype-phenotype mapping of the redundant representation. The obtained Pareto-optimal solutions are then analyzed to reveal the trade-off relationship between robustness and innovation of the redundant representation.
Aquifex aeolicus tRNA (N2,N2-Guanine)-dimethyltransferase (Trm1) Catalyzes Transfer of Methyl Groups Not Only to Guanine 26 but Also to Guanine 27 in tRNA (2009)

Transfer RNA (N2,N2-guanine)-dimethyltransferase (Trm1) catalyzes N2,N2-dimethylguanine formation at position 26 (m(2)(2)G26) in tRNA. In the reaction, N2-guanine at position 26 (m(2)G26) is generated as an intermediate. The trm1 genes are found only in archaea and eukaryotes, although it has been reported that Aquifex aeolicus, a hyper-thermophilic eubacterium, has a putative trm1 gene. To confirm whether A. aeolicus Trm1 has tRNA methyltransferase activity, we purified recombinant Trm1 protein. In vitro methyl transfer assay revealed that the protein has a strong tRNA methyltransferase activity. We confirmed that this gene product is expressed in living A. aeolicus cells and that the enzymatic activity exists in cell extract. By preparing 22 tRNA transcripts and testing their methyl group acceptance activities, it was demonstrated that this Trm1 protein has a novel tRNA specificity. Mass spectrometry analysis revealed that it catalyzes methyl transfers not only to G26 but also to G27 in substrate tRNA. Furthermore, it was confirmed that native tRNA(Cys) has an m(2)(2)G26m(2)G27 or m(2)(2)G26m(2)(2)G27 sequence, demonstrating that these modifications occur in living cells. Kinetic studies reveal that the m2G26 formation is faster than the m(2)G27 formation and that disruption of the G27-C43 base pair accelerates velocity of the G27 modification. Moreover, we prepared an additional 22 mutant tRNA transcripts and clarified that the recognition sites exist in the T-arm structure. This long distance recognition results in multisite recognition by the enzyme.
The minimum information required for a glycomics experiment (MIRAGE) project: sample preparation guidelines for reliable reporting of glycomics datasets (2016)

The minimum information required for a glycomics experiment (MIRAGE) project was established in 2011 to provide guidelines to aid in data reporting from all types of experiments in glycomics research including mass spectrometry (MS), liquid chromatography, glycan arrays, data handling and sample preparation. MIRAGE is a concerted effort of the wider glycomics community that considers the adaptation of reporting guidelines as an important step towards critical evaluation and dissemination of datasets as well as broadening of experimental techniques worldwide. The MIRAGE Commission published reporting guidelines for MS data and here we outline guidelines for sample preparation. The sample preparation guidelines include all aspects of sample generation, purification and modification from biological and/or synthetic carbohydrate material. The application of MIRAGE sample preparation guidelines will lead to improved recording of experimental protocols and reporting of understandable and reproducible glycomics datasets.
Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis (2021)

Chronic inflammation generated by the tumor microenvironment is known to drive cancer initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor microenvironment promotes the secretion of diverse cytokines, in different types and stages of cancers. These cytokines may inhibit tumor development but alternatively may contribute to chronic inflammation that supports tumor growth in both autocrine and paracrine manners and have been linked to poor cancer outcomes. Such distinct sets of cytokines from the tumor microenvironment can be detected in the circulation and are thus potentially useful as biomarkers to detect cancers, predict disease outcomes and manage therapeutic choices. Indeed, analyses of circulating cytokines in combination with cancer-specific biomarkers have been proposed to simplify and improve cancer detection and prognosis, especially from minimally-invasive liquid biopsies, such as blood. Additionally, the cytokine signaling signatures of the peripheral immune cells, even from patients with localized tumors, are recently found altered in cancer, and may also prove applicable as cancer biomarkers. Here we review cytokines induced by the tumor microenvironment, their roles in various stages of cancer development, and their potential use in diagnostics and prognostics. We further discuss the established and emerging diagnostic approaches that can be used to detect cancers from liquid biopsies, and additionally the technological advancement required for their use in clinical settings.
Induction of circulating antagonists to IL-1 and TNF by IL-2 administration and their effects on IL-2 induced cytokine production in vitro. (1994)

The objectives of this study were to determine whether intensive immunotherapy with IL-2 results in detectable levels of circulating IL-1 and TNF antagonists and whether the levels achieved in vivo are sufficient to affect the generation of secondary proinflammatory cytokines such as IL-1 beta and TNF-alpha. We also sought to determine the extent to which endogenous TNF mediates the generation of an IL-1 antagonist by IL-2-activated PBMCs. In patients undergoing high dose IL-2 immunotherapy, plasma IL-1 receptor antagonist (IL-1ra) levels rose dramatically after the first IL-2 injection, reaching a plateau of 11.03 +/- 0.92 ng/ml within 4 h. TNF-soluble receptor p55 (TNFsRp55) was also detected in the plasma shortly after initiating treatment, and the levels progressively increased throughout the treatment course. PBMCs exposed to IL-2 expressed IL-1ra mRNA and secreted the IL-1ra protein, but neither PBMCs nor neutrophils shed TNFsRp55 in response to IL-2 or supernatants from IL-2-activated PBMCs. IL-1ra at concentrations achieved in the plasma during IL-2 immunotherapy (approximately 10 ng/ml) inhibited the in vitro production of IL-1 beta and TNF-alpha by IL-2-activated PBMCs by 65% and 30%, respectively. Although the monomeric receptor TNFsRp55 at concentrations achieved in the plasma had no effect on the in vitro production of IL-1ra, TNF-alpha, or IL-1 beta, the bivalent TNFsRp75-Fc chimera suppressed the generation of TNF and IL-1. IL-1ra synthesis was unaffected. These results suggest that the amount of IL-1ra generated in response to IL-2 is most likely sufficient to down-modulate the production of proinflammatory cytokines.
Finding categories (2010)

Assigning categorical labels to objects in images has proven to be a significant challenge for automated systems. As cameras rapidly proliferate our society, however, we will necessarily depend more heavily on computers to help us label and sort our images. This work addresses the problem of trying to assign categorical labels to images. We contend that to do this task effectively, we should consider also which part of the image contains the object. 
We examine the sensitivity of feature detection to nuisances and propose a new feature detector based on a tree of segmentations. When a detector is not required, we describe a fast adaptation that extracts a popular descriptor (SIFT) on a dense grid on the image. Next, we show that a dictionary constructed for the task of categorization can be both smaller and more accurate than one constructed to represent the data alone. We explore splitting descriptors along segmentation boundaries, and show that knowing which part of an image contains the object can make a large difference in accuracy. With these pieces, we construct a fast and accurate pixel-level categorization technique. Then, we move from pixels to small homogeneous collections of pixels (superpixels) and exploit the neighborhood structure of these to form precise superpixel-level categorization. 
Finally, the appendix discusses open software we have developed and released including a GPU implementation of a segmentation algorithm (quick shift) and a MATLAB experiment framework (Blocks) which implements the techniques described in the thesis.
Disulfide Chromophores Arise from Stereoelectronic Effects (2020)

Bonds between sulfur atoms are prevalent in natural products, peptides, and proteins. Disulfide bonds have a distinct chromophore. The wavelength of their maximal absorbance varies widely, from 250 to 500 nm. Here, we demonstrate that this wavelength derives from stereoelectronic effects and is predictable using quantum chemistry. We also provide a sinusoidal equation, analogous to the Karplus equation, that relates the absorbance maximum and the C-S-S-C dihedral angle. These insights provide a facile means to characterize important attributes of disulfide bonds and to design disulfides with specified photophysical properties.
Intravesical Oncoviral Therapy for Bladder Cancer (2012)

No AccessJournal of UrologyEditorial1 Dec 2012Intravesical Oncoviral Therapy for Bladder Cancer Alan So, Paul S. Rennie, and William Jia Alan SoAlan So , Paul S. RenniePaul S. Rennie , and William JiaWilliam Jia View All Author Informationhttps://doi.org/10.1016/j.juro.2012.09.044AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Intravesical Oncoviral Therapy for Bladder Cancer." The Journal of Urology, 188(6), pp. 2039–2040 References 1 : A first in human phase 1 study of CG0070, a GM-CSF expressing oncolytic adenovirus, for the treatment of nonmuscle invasive bladder cancer. J Urol2012; 188: 2391. Link, Google Scholar 2 : Direct endoscopic intratumoral injection of Onyx for the preoperative embolization of a recurrent juvenile nasal angiofibroma. Intervent Neuroradiol2011; 17: 477. Google Scholar 3 : Comparison of intravenous versus intraperitoneal administration of oncolytic herpes simplex virus 1 for peritoneal carcinomatosis in mice. Cancer Gene Ther2009; 16: 291. Google Scholar 4 : Preclinical pharmacology and toxicology of intravenous MV-NIS, an oncolytic measles virus administered with or without cyclophosphamide. Clin Pharmacol Therap2007; 82: 700. Google Scholar 5 : Down-regulation of type I interferon receptor sensitizes bladder cancer cells to vesicular stomatitis virus-induced cell death. Int J Cancer2010; 127: 830. Google Scholar 6 : Oncolytic vesicular stomatitis viruses are potent agents for intravesical treatment of high-risk bladder cancer. Cancer Res2008; 68: 4506. Google Scholar Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Surgery, University of British Columbia, Vancouver, British Columbia, Canada© 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 188Issue 6December 2012Page: 2039-2040 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Alan So More articles by this author Paul S. Rennie More articles by this author William Jia More articles by this author Expand All Advertisement PDF DownloadLoading ...
ICON: Eosinophil Disorders (2012)

Eosinophil disorders and related syndromes are a heterogeneous group of conditions characterized by marked persistent blood eosinophilia and involvement of one or more organ systems. The hypereosinophilic (HE) state is defined by a persistent eosinophil count exceeding 1.5 10 9 /L blood.
Stretching the Limits of Clock-Gating Efficiency in Server-Class Processors (2005)

Clock-gating has been introduced as the primary means of dynamic power management in recent high-end commercial microprocessors. The temperature drop resulting from active power reduction can result in additional leakage power savings in future processors. In this paper we first examine the realistic benefits and limits of clock-gating in current generation high-performance processors (e.g. of the POWER4/spl trade/ or POWER5/spl trade/ class). We then look beyond classical clock-gating: we examine additional opportunities to avoid unnecessary clocking in real workload executions. In particular, we examine the power reduction benefits of a couple of newly invented schemes called transparent pipeline clock-gating and elastic pipeline clock-gating. Based on our experiences with current designs, we try to bound the practical limits of clock gating efficiency in future microprocessors.
Evolutionally conserved plant homologue of the Bax Inhibitor‐1 (BI‐1) gene capable of suppressing Bax‐induced cell death in yeast1 (1999)

The plant homologue of Bax Inhibitor-1, a gene described to suppress the cell death induced by Bax gene expression in yeast, was isolated from Oryza sativa L. (rice) and Arabidopsis. The amino acid sequence of the predicted protein was well conserved in both animal and plant (45% in amino acids) and contained six or seven membrane-spanning segments. Northern blot analysis showed that OsBI-1 transcripts were present in all tissues examined. The OsBI-1 cDNA suppressed cell death induced by mammalian Bax in yeast, suggesting functional conservation of this BI-1 homologue in the plant kingdom.
Supplemental figure 12 from Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies (2023)

&lt;p&gt;PP2A activator PTZ does not enhance ABBV-075 induced apoptosis in solid tumor cell lines&lt;/p&gt;
ChemInform Abstract: Cyanocuprate‐Catalyzed 1,4‐Additions of Vinylic Zirconocenes Using a Zincate as an Organolithium “Shuttle”. A New and Potentially Practical Approach to 3‐Component Couplings. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Wavelength dependence of the apparent diameter of retinal blood vessels (2005)

Imaging of retinal blood vessels may assist in the diagnosis and monitoring of diseases such as glaucoma, diabetic retinopathy, and hypertension. However, close examination reveals that the contrast and apparent diameter of vessels are dependent on the wavelength of the illuminating light. In this study multispectral images of large arteries and veins within enucleated swine eyes are obtained with a modified fundus camera by use of intravitreal illumination. The diameters of selected vessels are measured as a function of wavelength by cross-sectional analysis. A fixed scale with spectrally independent dimension is placed above the retina to isolate the chromatic effects of the imaging system and eye. Significant apparent differences between arterial and venous diameters are found, with larger diameters observed at shorter wavelengths. These differences are due primarily to spectral absorption in the cylindrical blood column.
Patient Classification (1993)

In our commentary on the article by Delitto et al entitled “Evidence for Use of an Extension-Mobilization Category in Acute Low Back Syndrome: A Prescriptive Validation Pilot Study” in the April 1993 issue of Physical Therapy, we suggested that, in view of the significant differences between the treatment groups for age and the marked (although nonsignificant) differences in days since onset of back pain, the authors should have used an analysis of covariance (ANCOVA) rather than an analysis of variance (ANOVA). In reply, the authors confess to being confused by our position. They assert that the ANCOVA is a statistical technique for increasing the precision (power) of analysis, and, as their ANOVA had already yielded a significant difference between the treatment groups, there seemed no justification for use of an ANCOVA. Anthony Delitto, PhD, PT, Assistant Professor, Department of Physical Therapy, School of Health and Rehabilitation, Sciences, University of Pittsburgh Medical Center, 101 Pennsylvania Hall, Pittsburgh, PA 15261 Richard E Erhard, DC, PT, Adjunct Professor, Department of Physical Therapy, School of Health and Rehabilitation, Sciences, University of Pittsburgh Medical Center. Richard W Bowling, PT, Adjunct Professor, Department of Physical Therapy, School of Health and Rehabilitation, Sciences, University of Pittsburgh Medical Center.
Effect of a cell free haemoglobin solution (DCLHb) on erythrocyte deformability and aggregation (2000)

European Society of Anaesthesiologists; 8th Annual Meeting with the Austrian International Congress; Vienna, Austria, 1-4 April 2000
Correction to Catalytic Upgrading of Light Naphtha to Gasoline Blending Components: A Mini Review (2020)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Catalytic Upgrading of Light Naphtha to Gasoline Blending Components: A Mini ReviewAbdullah Aitani*Abdullah AitaniMore by Abdullah Aitanihttp://orcid.org/0000-0001-5071-4034, Muhammad Naseem AkhtarMuhammad Naseem AkhtarMore by Muhammad Naseem Akhtar, Sulaiman Al-KhattafSulaiman Al-KhattafMore by Sulaiman Al-Khattaf, Yaming Jin*Yaming JinMore by Yaming Jin, Omer KoseogluOmer KoseogluMore by Omer Koseoglu, and Michael T. KleinMichael T. KleinMore by Michael T. Kleinhttp://orcid.org/0000-0001-5444-1512Cite this: Energy Fuels 2020, 34, 2, 2617Publication Date (Web):February 12, 2020Publication History Published online12 February 2020Published inissue 20 February 2020https://pubs.acs.org/doi/10.1021/acs.energyfuels.9b04074https://doi.org/10.1021/acs.energyfuels.9b04074correctionACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views699Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (274 KB) Get e-Alertsclose Get e-Alerts