gebhart/patrepeval huggingface dataset:
MotionLab Sonify: A Framework for the Sonification of Human Motion Data (2006)

Sonification of human movement offers a wide range of new kinds of information for supporting motor learning in sports and rehabilitation. Even though motor learning is dominated visually, auditory perception offers unique subtle temporal resolution as well as enormous integrative capacity - both are important features on perception of human movement patterns. But how to address the auditory system adequately? A sonification based on kinematic movement data can mediate structural features of movement via the auditory system, like polyrhythms of movement etc. And sonification of dynamic movement data makes muscle forces audible approximately. Here, a flexible framework for the sonification of human movement data is presented, capable of processing standard kinematic motion capture data as well as derived quantities such as force data. Force data are computed by inverse dynamics algorithms and can be used as input parameters for real time sonification. Simultaneous visualization is provided using OpenGL.
Truncating Variants in RFC1 in Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome (2022)

Our report expands the genotype spectrum of RFC1 disease. Full <i>RFC1</i> sequencing is recommended in cases affected by typical CANVAS and carrying monoallelic (AAGGG)<sub>n</sub> expansions. In addition, it sheds further light on the pathogenesis of RFC1 CANVAS because it supports the existence of a loss-of-function mechanism underlying this complex neurodegenerative condition.
Faculty Opinions recommendation of Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons. (2003)

Rho-GTPase has been implicated in axon outgrowth. However, not all of the critical steps controlled by Rho have been well characterized. Using cultured cerebellar granule neurons, we show here that stromal cell-derived factor (SDF)-1alpha, a neural chemokine, is a physiological ligand that can turn on two distinct Rho-dependent pathways with opposite consequences. A low concentration of the ligand stimulated a Rho-dependent pathway that mediated facilitation of axon elongation. In contrast, Rho/ROCK activation achieved by a higher concentration of SDF-1alpha caused repression of axon formation and induced no more increase in axon length. However, even at this higher concentration a Rho-dependent axon elongating activity could be recovered upon removal of ROCK activity using Y-27632. SDF-1alpha-induced axon elongating activity under ROCK inhibition was replicated by the dominant-active form of the mammalian homologue of the Drosophila gene Diaphanous (mDia)1 and counteracted by its dominant-negative form. Furthermore, RNAi knockdown of mDia1 abolished SDF-1alpha-induced axon elongation. Together, our results support a critical role for an SDF-1alpha/Rho/mDia1 pathway in mediating axon elongation. PMID: 12707308
Composed Multicore Fiber Structure for Extended Sensor Multiplexing with Fiber Bragg Gratings (2022)

A novel multicore optical waveguide component based on a fiber design optimized towards selective grating inscription for multiplexed sensing applications is presented. Such a fiber design enables the increase in the optical sensor capacity as well as extending the sensing length with a single optical fiber while preserving the spatial sensing resolution. The method uses a multicore fiber with differently doped fiber cores and, therefore, enables a selective grating inscription. The concept can be applied in a draw tower inscription process for an efficient production of sensing networks. Along with the general concept, the paper discusses the specific preparation of the fiber-based sensing component and provides experimental results showing the feasibility of such a sensing system.
N-(4-Nitrobenzyl)benzene-1,2-diamine (2006)

In the crystal structure of the title compound, C13H13N3O2, one-dimensional chains of hydrogen-bonded dimers are linked by π–π stacking inter­actions.
Electron-transfer reaction of macromolecular cobalt(III) complex with [Ru(NH3)6]2+. Effect of microenvironment occupied by polymer backbone (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron-transfer reaction of macromolecular cobalt(III) complex with [Ru(NH3)6]2+. Effect of microenvironment occupied by polymer backboneYoshimi Kurimura, Takashi Kikuchi, and Eishun TsuchidaCite this: Macromolecules 1989, 22, 4, 1645–1648Publication Date (Print):April 1, 1989Publication History Published online1 May 2002Published inissue 1 April 1989https://pubs.acs.org/doi/10.1021/ma00194a025https://doi.org/10.1021/ma00194a025research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Video--pre- PEGPH20 tumor vascular area from Enzymatic Depletion of Tumor Hyaluronan Induces Antitumor Responses in Preclinical Animal Models (2023)

&lt;p&gt;Video - 2-D ultrasound cine loop of pre- PEGPH20 tumor vascular area 15 mg/kg PEGPH20 at t = 0; Mouse #149&lt;/p&gt;
ChemInform Abstract: Selective Cleavage of Benzyl Ethers. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Circulating tumor cell enumeration combined with gene expression analysis and clinical variables in castrate resistant prostate cancer (2008)

B33 Introduction: Enumeration of circulating tumor cells (CTCs) provides independent prognostic information in castrate resistant prostate cancer (CRPC). Expression of prostate cancer specific genes can be observed in peripheral blood cells following CTC-enrichment, and the molecular profiles of these cells has potential applications in predicting disease progression and in treatment selection. Serum prostate specific antigen (PSA) levels are regularly measured and reflect cancer growth and disease activity in castrate-resistant prostate cancer (CRPC). Here, we describe preliminary results of a pilot study to link CTC enumeration and targeted gene expression analysis with PSA and other clinical variables in CRPC. Methods: One 7.5ML volume of EDTA anti-coagulated bloodfor EpCAM-based immunomagnetic enrichment followed by QiagenRNA extraction and one 7.5ML volume of CellSaveTM preservedblood was collected for CTC enumeration and analysis was obtained from subjects prior to initiation of a cytotoxic chemotherapy (initial or salvage) for CRPC at time of disease progression. Clinical and pathological data including PSA is collected. RNA is analyzed by quantitative real-time RT-PCR. CTC enrichment and expression analysis from normal donors were performed in parallel as controls. Results: Data are available from the first 15 subjects enrolled. CTC elevation (≥1/ 7.5 ml blood) was found in 13 of 15 subjects and in 0 of 37 normal controls. Median (range) for CTCs was 17 (0-2362) cells/7.5 ml and for PSA was 261.4 (0.1-961.1) ng/ml. PSA doubling time could be calculated in 11 subjects with a median of 1.7 (0.2-5.3) months. Gene expression data are available for 11 subjects with CTC ≥ 5 and all normal controls. Elevated expression in subjects compared with controls was noted for several genes including: TACSTD (EpCAM; n=10); platelet-derived growth factor (PDEF; n=4); epidermal growth factor receptor (EGFR, n=2), human epidermal growth factor receptor - 2 (HER2, n=2); androgen receptor (AR; n=8); and PSA (n=9). Co-expression of EGFR/HER2 (n=2) and AR/PSA (n=8) was observed. Conclusion: CTCs can be isolated and analyzed for gene expression patterns from patients with progressive CRPC. Analysis of this data in conjunction with serum PSA and other clinical variables may provide greater biologic insight into the nature of CTCs and provide a non-invasive assay to direct and monitor therapy in CRPC.
Finger joint kinematics from MR images (2005)

Accurate and quantitative analysis of human hand motion requires an understanding of the kinematics of the proximal and distal interphalangeal joints in three dimensions. This paper presents a technique to investigate in-vivo finger joint kinematics using magnetic resonance (MR) imaging. Bone surface models were extracted from MR images of the right hand of ten healthy subjects in four different postures. The relative motion of adjacent bones for all subjects was calculated and expressed as the helical axis and the angles around the axes of local bone coordinate system. The motion data indicated the change of axis orientation with flexion. After carefully selecting the subject and a pose with an appropriate flexional angle, studies determined that the mean inclination between the axes of the proximal and distal interphalangeal joints was approximately 14 [deg].
Fault-tolerant replication management in large-scale distributed storage systems (2003)

Failures of all forms happen: from losing single network packets to site-wide disasters. Since businesses rely heavily on their data, it is imperative that failures require minimal time and effort to repair and that the service interruption during the failure or repair period should be as short as possible. To this end, the ideal system should repair itself relying on humans only when absolutely necessary in the repair process. This paper describes one component of a self-healing storage system: the component that allows for automatic recovery of access to data when the power comes back on after a large-scale outage. Our failure recovery, protocol is part of a suite of modular protocols that make up the Palladio distributed storage system. This protocol guarantees that service will be repaired quickly and automatically when enough failures are repaired.
A novel pathway for phosphorylated oligosaccharide biosynthesis. Identification of an oligosaccharide-specific phosphate methyltransferase in dictyostelium discoideum. (1992)

The N-linked oligosaccharides on three lysosomal enzymes in Dictyostelium discoideum were found to contain mannose 6-phosphomethyl residues. We have identified and partially characterized a novel S-adenosylmethionine-dependent methyltransferase that is probably responsible for the synthesis of this unusual diester from Man-6-P. The enzyme selectively methylates the phosphate group of Man-6-P (Km 4.3 mM). Glucose-6-P and fructose-1-P are relatively poor acceptors; however, the enzyme is inactive against a broad array of other phosphorylated compounds. Using model di-, tri-, and pentasaccharide acceptors that include portions of the three different branches of high mannose-type oligosaccharides, we found that the enzyme prefers terminal alpha 1----2-linked Man-6-P residues (Km 0.15-1.25 mM) found on the known phosphorylated branches. The enzyme is membrane bound, has a neutral pH optimum and cofractionates on sucrose gradients with GlcNAc-1-P transferase, which resembles its mammalian counterpart, and is, presumably, the first enzyme in the phosphorylation pathway. Based on the substrate specificity and colocalization with GlcNAc-1-P transferase, the phosphate methyltransferase is likely to be responsible for the generation of mannose-6-phosphomethyldiester on Dictyostelium oligosaccharides.
The design of efficiently-encodable rate-compatible LDPC codes - [transactions papers] (2009)

We present a new class of irregular low-density parity-check (LDPC) codes for moderate block lengths (up to a few thousand bits) that are well-suited for rate-compatible puncturing. The proposed codes show good performance under puncturing over a wide range of rates and are suitable for usage in incremental redundancy hybrid-automatic repeat request (ARQ) systems. In addition, these codes are linear-time encodable with simple shift-register circuits. For a block length of 1200 bits the codes outperform optimized irregular LDPC codes and extended irregular repeat-accumulate (eIRA) codes for all puncturing rates 0.6~0.9 (base code performance is almost the same) and are particularly good at high puncturing rates where good puncturing performance has been previously difficult to achieve.
Biopolymer-reinforced synthetic granular nanocomposites for affordable point-of-use water purification (2013)

Creation of affordable materials for constant release of silver ions in water is one of the most promising ways to provide microbially safe drinking water for all. Combining the capacity of diverse nanocomposites to scavenge toxic species such as arsenic, lead, and other contaminants along with the above capability can result in affordable, all-inclusive drinking water purifiers that can function without electricity. The critical problem in achieving this is the synthesis of stable materials that can release silver ions continuously in the presence of complex species usually present in drinking water that deposit and cause scaling on nanomaterial surfaces. Here we show that such constant release materials can be synthesized in a simple and effective fashion in water itself without the use of electrical power. The nanocomposite exhibits river sand-like properties, such as higher shear strength in loose and wet forms. These materials have been used to develop an affordable water purifier to deliver clean drinking water at US $2.5/y per family. The ability to prepare nanostructured compositions at near ambient temperature has wide relevance for adsorption-based water purification.
Effect of Microbubble Ligation to Cells on Ultrasound Signal Enhancement (2006)

Attachment of targeted microbubbles to rigid surfaces results in damping and a reduction of their acoustic signal, which is not seen when microbubbles are attached to cells. A reliable concentration versus intensity relationship can be expected from microbubble attachment to 2-dimensional surfaces until a very high site density is reached.
A Whole-Cell Surface Plasmon Resonance Sensor Based on a Leucine Auxotroph of Escherichia coli Displaying a Gold-Binding Protein: Usefulness for Diagnosis of Maple Syrup Urine Disease (2016)

We developed a whole-cell surface plasmon resonance (SPR) sensor based on a leucine auxotroph of Escherichia coli displaying a gold-binding protein (GBP) in response to cell growth and applied this sensor to the diagnosis of maple syrup urine disease, which is represented by the elevated leucine level in blood. The leucine auxotroph was genetically engineered to grow displaying GBP in a proportion to the concentration of target amino acid leucine. The GBP expressed on the surface of the auxotrophs directly bound to the golden surface of an SPR chip without the need for any additional treatment or reagents, which consequently produced SPR signals used to determine leucine levels in a test sample. Gold nanoparticles (GNPs) were further applied to the SPR system, which significantly enhanced the signal intensity up to 10-fold by specifically binding to GBP expressed on the cell surface. Finally, the diagnostic utility of our system was demonstrated by its employment in reliably determining different statuses of maple syrup urine disease based on a known cutoff level of leucine. This new approach based on an amino acid-auxotrophic E. coli strain expressing a GBP that binds to an SPR sensor holds great promise for detection of other metabolic diseases of newborn babies including homocystinuria and phenylketonuria, which are also associated with abnormal levels of amino acids.
Complex Band-Pass Filters for Analytic Signal Generation and Their Application (2001)

The generation of the pre-envelope and complex envelope of an arbitrary band-pass component of a digitized signal is presented. In particular, the complex band-pass filter method of analytic signal generation is generalized. Synchronization is also addressed and an example application of interference cancellation is given.
Object-based image watermarking technique using wavelets (2004)

We present a wavelet-based image watermarking algorithm that is able to embed the watermark information into objects within an image. In the proposed algorithm, the zerotrees in the wavelet coefficient domain corresponding to the selected object(s) are identified. Then the watermark is embedded into the bandpass wavelet coefficients with large amplitudes within these zerotrees by using an appropriate quantization process. The bitmap of the zerotrees corresponding to the selected objects, the wavelet used for the transform, and the parameters for the transform and quantization are chosen as the keys for the proposed algorithm. The effectiveness of the proposed watermarking technique and its robustness against some commonly encountered image processing operations are demonstrated through simulation studies.
Polarization-maintaining fiber based polarization-sensitive optical coherence tomography in spectral domain (2010)

We demonstrate a polarization-sensitive spectral-domain optical coherence tomography system based on polarization-maintaining fiber technology. Using a single-line-scan camera, the system produces reflectivity and retardance information along a depth profile with a single measurement. The relative axis orientation is available as well. System design and characterization and images of a biological tissue are presented.
A Framework for Optimization of the Traction Motor Design Based on the Series-HEV System Level Goals (2014)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The fidelity of the hybrid electric vehicle simulation is increased with the integration of a computationally-efficient finite-element based electric machine model, in order to address optimization of component design for system level goals. In-wheel electric motors are considered because of the off-road military application which differs significantly from commercial HEV applications. Optimization framework is setup by coupling the vehicle simulation to the constrained optimization solver. Utilizing the increased design flexibility afforded by the model, the solver is able to reshape the electric machine's efficiency map to better match the vehicle operation points. As the result, the favorable design of the e-machine is selected to improve vehicle fuel economy and reduce cost, while satisfying performance constraints.&lt;/div&gt;&lt;/div&gt;
Confocal microscopy with a volume holographic filter (1999)

We describe a modified confocal microscope in which depth discrimination results from matched filtering by a volume hologram instead of a pinhole filter. The depth resolution depends on the numerical aperture of the objective lens and the thickness of the hologram, and the dynamic range is determined by the diffraction efficiency. We calculate the depth response of the volume holographic confocal microscope, verify it experimentally, and present the scanned image of a silicon wafer with microfabricated surface structures.
Coacervation of the Recombinant Mytilus galloprovincialis Foot Protein-3b (2018)

The underwater adhesion of marine mussels is a fascinating example of how proteinaceous adhesives, although water-soluble to begin with, can be used in seawater. Marine mussels adhere to the substrate via adhesive plaques, where the adhesive proteins are located especially at the substratum's interface. One major compound of the adhesives in Mytilidae is the mussel foot protein 3b (mfp-3b). Here, recombinant mfp-3b (rmfp-3b) was produced in Escherichia coli. rmfp-3b showed upper critical solution temperature (UCST) mediated complex coacervation at pH 3.0 in the presence of citrate yielding a liquid-liquid phase separation. Further, the rmfp-3b coacervation could also be induced in seawater conditions such as the respective pH and ionic strength, but without UCST behavior. In particular, sulfate and citrate anions could significantly induce complex coacervation. This study provides insights into the molecular behavior of one of the key proteins of mussels involved in underwater adhesion and may inspire new applications of bioadhesives using recombinant mussel foot proteins.
Evaluation of Neurodegeneration in a Mouse Model of Infantile Batten Disease by Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy (2012)

Neuronal ceroid lipofuscinoses (NCLs) represent a group of common hereditary childhood neurodegenerative storage disorders that have no effective treatment. Mutations in eight different genes cause various forms of NCLs. Infantile NCL (INCL), the most lethal disease, is caused by inactivating mutations in the palmitoyl-protein thioesterase-1 (PPT1) gene. The availability of Ppt1-knockout (Ppt1-KO) mice, which recapitulate virtually all clinical and pathological features of INCL, provides an opportunity to test the effectiveness of novel therapeutic strategies in vivo. However, such studies will require noninvasive methods that can be used to perform serial evaluations of the same animal receiving an experimental therapy. Thus, the development of noninvasive method(s) of evaluation is urgently needed. Here, we report our evaluation of the progression of neurodegeneration in Ppt1-KO mice starting at 3 months of age by MRI and MR spectroscopy (MRS) and repeating these tests using the same mice at 4, 5 and 6 months of age. Our results showed progressive cerebral atrophy, which was associated with histological loss of neuronal content and increase in astroglia. Remarkably, while the brain volumes in Ppt1-KO mice progressively declined with advancing age, the MRS signals, which were significantly lower than those of their wild-type littermates, remained virtually unchanged from 3 to 6 months of age. In addition, our results also showed an abnormality in cerebral blood flow in these mice, which showed progression with age. Our findings provide methods to serially examine the brains of mouse models of neurodegenerative diseases (e.g. Ppt1-KO mice) using noninvasive and nonlethal procedures such as MRI and MRS. These methods may be useful in studies to understand the progression of neuropathology in animal models of neurodegenerative diseases as they allow repeated evaluations of the same animal in which experimental therapies are tested.