gebhart/patrepeval huggingface dataset:
The effect of transportation noise on sleep and its consequential effect on health (2019)

Sleep disruption by noise is a well-known phenomenon that has demonstrated negative health and cognitive impacts. Furthermore, it has now been determined that individuals suffering from certain health conditions, including PTSD and atrial fibrillation, may actually experience enhanced noise sensitivity with additional risks. This paper presents the results of several studies that confirm the importance of addressing transportation noise, over which individuals typically have no control, to protect environments intended for sleep such as hospitals, senior housing facilities, and residences.
New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries (2011)

SOCS (suppressor of cytokine signalling) proteins are negative-feedback regulators of the JAK (Janus kinase)/STAT (signal transducer and activator of transcription) pathway. Their expression levels are low under physiological conditions, but they are up-regulated in response to cytokine stimulation in many immune and inflammatory processes. Overexpression of SOCS1 in keratinocyte clones abrogates the IFNγ (interferon γ)-induced expression of many pro-inflammatory genes and the release of related chemokines by blocking the JAK/STAT pathway. SOCS1 inhibits JAK2 kinase activity by binding the catalytic site of JAK2, with its KIR (kinase-inhibitory region) acting as a pseudo-substrate of the enzyme. In the present study, we screened a focused combinatorial peptide library of KIR to identify new peptides able to mimic its function with an improved affinity towards the JAK2 catalytic site. Using an alanine-scanning method, KIR residues that are crucial for the interaction with JAK2 were unveiled. In this way, the KIR sequence was restricted to a shorter segment and ‘non-essential’ residues were replaced by different amino acids following a simplified combinatorial approach. We selected a new unnatural sequence able to bind to JAK2 with Kd values in the nanomolar range. This peptide was tested in human keratinocyte cultures and reduced the phosphorylation of STAT1 and the expression levels of IRF-1 (interferon regulatory factor-1).
An Active Vision Based SAR-FLIR Fusion ATR System for Detection and Recognition of Ground Targets (1996)

Abstract : (1) A constant False Alarm Rate (CFAR) has been developed and implemented for real time performance on an inexpensive Single Instruction Multiple Data (SIMD) hardware. (2) An innovative registration algorithm has been developed to register the SAR-passive image pair. (3) A model-based recognition scheme using a model-image alignment approach has been implemented. (4) An end-to-end demonstration of the proof-of-concept demonstration of the SAR-passive image fusion approach has been accomplished.
Patterning Multiple Aligned Self-Assembled Monolayers Using Light (2004)

This work describes a method for patterning a gold substrate with multiple, aligned self-assembled monolayers (SAMs) using light at different wavelengths. It describes the synthesis and characterization of an alkanethiolate SAM that is photosensitive to light at both 220 and 365 nm. A photomask acts as an area-selective filter for light at 220 and 365 nm, and a single set of exposures at these two wavelengths through one photomask, without steps of alignment between the exposures, can produce three aligned SAMs on one gold substrate. We demonstrate the versatility of this method of photopatterning by modifying individual aligned SAMs chemically to produce surfaces having different properties. We characterize the modified SAMs using immunolabeling, matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy, and surface plasmon resonance spectroscopy. We also describe the patterning of two aligned SAMs that resist the adsorption of proteins and a third region that does not resist the adsorption of proteins. The ability to produce multiple, aligned patterns of SAMs in a single step, without alignment of photomasks in separate steps, increases the versatility of SAMs for studying a range of physical phenomena.
Photochemical Reactions of 2,4-Diethyl-2,4-diphenyl-1,3-cyclobutanedione in Benzene and in Isopropyl Alcohol1 (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTPhotochemical Reactions of 2,4-Diethyl-2,4-diphenyl-1,3-cyclobutanedione in Benzene and in Isopropyl Alcohol1Hongmei Zang and Douglas C. NeckersView Author Information Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403 Cite this: J. Org. Chem. 1999, 64, 6, 2103–2106Publication Date (Web):February 26, 1999Publication History Received14 April 1998Published online26 February 1999Published inissue 1 March 1999https://pubs.acs.org/doi/10.1021/jo9806862https://doi.org/10.1021/jo9806862brief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views177Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Hydrocarbons,Irradiation,Phenyls,Solvents Get e-Alerts
EXPERIMENTAL STUDY ON DEFORMATION CAPACITY BEYOND FLEXURAL YIELDING OF WALL COLUMNS (1990)

Seismic tests of thirteen columns with large depth (D)-to-width (b) ratio (hereafter referred to as "Wall Columns") were conducted. The main variables in the tests were : 1) confinement in the compression zone, 2) depth-to-width ratio, 3) presence of transverse walls, and 4) axial stress level. All of the speciments behaved in a ductile manner, and their final failure was caused by the crushing of concrete in the compressive edge zone. The following conclusions concerning the deformation capacity were obtained from this tests and investigations. (1) Confinement of concrete in the compressive edge zone is very effective to increase the deformation capacity of wall columns. (2) The deformation capacity dramatically decreases when the depth-to-width ratio of wall columns increases. (3) The wall columns with transverse walls behave in a ductile manner more than the wall columns without them if they are in the compression zone. (4) The smaller the axial stress level is, the greater the deformation capacity is. (5) The deformation capacity can be estimated by the flexural theory if the stress versus strain relation of confined concrete, including the negative slope after the maximum compression strength is properly defined.
Luteinizing Hormone-Releasing Hormone Receptor-Targeted Chemotherapy Using AN-152 (2009)

The luteinizing hormone-releasing hormone (LHRH; also known as gonadotropin-releasing hormone) receptor can be utilized for targeted chemotherapy with cytotoxic LHRH analogues such as AN-152, in which doxorubicin is linked to [D-Lys(6)]LHRH. Our studies demonstrate receptor-mediated actions of the cytotoxic LHRH analogue AN-152 in LHRH receptor-positive endometrial and ovarian tumors in vivo. Intravenous administration of AN-152 is far less toxic and inhibits the growth of LHRH receptor-positive tumors better than equimolar doses of the cytotoxic agent doxorubicin. AN-152 has no antitumor activity in LHRH receptor-negative cancers. This provides evidence for the principle of targeted cytotoxic chemotherapy to tumor cells expressing LHRH receptors. In addition, we were able to show that LHRH binding sites were only slightly reduced after AN-152 treatment. Therefore, repeated therapy is considered to be possible. The majority (80%) of human endometrial and ovarian cancers and about 50% of breast cancers express LHRH receptors. In addition, apart from reproductive organs, which are normally removed during surgical therapy, other organs and hematopoietic stem cells do not express LHRH receptors. Thus, cytotoxic LHRH analogues such as AN-152 appear to be suitable drugs for a more efficacious and less toxic targeted chemotherapy for endometrial and ovarian cancers. A recently finished phase I study assessed the dose limitations, maximum tolerated dose and pharmacokinetics of AN-152 given once every 3 weeks in patients with gynecological and breast cancers. A phase II study was started in January 2008.
Fine structural analysis of the cortico‐striatal pathway (1979)

Abstract Considerable evidence has accumulated indicating that one neurotransmitter in the excitatory cortico‐striatal tract is glutamate. Lesions of the tract result in reductions in the striatum of glutamate levels as well as high affinity uptake of glutamate into synaptosomes. Furthermore, such lesions leminate the neurotoxicity of the glutamate analog kainic acid when injected into the striatum. The fine structure of the cortico‐striatal pathway was studied to provide evidence regarding the morphology of glutamate nerve endings. Seven days after injection of 3 H‐proline (20–25 μCi) into the rat frontal cortex, axonally transported label appeared in the striatum with uniform distribution in a single type of nerve ending. The labeled boutons had common round vesicles and made asymmetrical contacts, mostly with dendritic spines. This morphology is typical of excitatory synapses, and similar to that previously shown for cholinergic boutons in the striatum. In four animals similarly injected with 3 H‐proline, kainic acid was administered directly into the striatum to induce degeneration of postsynaptic elements eight to ten hours before sacrifice. In areas affected by these injections, grains appear in pathches, possibly resulting from glial swelling. Labeled boutons were seen almost four times as often in synaptic contact with degenerating dendritic elements as with normal ones. The data provide morphological evidence as to the nature of the probable glutamatergic boutons in the striatum, and show the close relationship of such boutons with the neurotoxic effects of kainic acid. This would be anticipated in view of the dependency of kainic acid neurotoxicity on the intergrity of the cortico‐striatal pathway.
Inhibition of the lectin pathway of complement activation reduces LPS-induced acute respiratory distress syndrome in mice (2023)

Acute respiratory distress syndrome (ARDS) is a life-threatening disorder with a high rate of mortality. Complement activation in ARDS initiates a robust inflammatory reaction that can cause progressive endothelial injury in the lung. Here, we tested whether inhibition of the lectin pathway of complement could reduce the pathology and improve the outcomes in a murine model of LPS-induced lung injury that closely mimics ARDS in human. <i>In vitro</i>, LPS binds to murine and human collectin 11, human MBL and murine MBL-A, but not to C1q, the recognition subcomponent of the classical pathway. This binding initiates deposition of the complement activation products C3b, C4b and C5b-9 on LPS <i>via</i> the lectin pathway. HG-4, a monoclonal antibody that targets MASP-2, a key enzyme in the lectin pathway, inhibited lectin pathway functional activity <i>in vitro</i>, with an IC<sub>50</sub> of circa 10nM. Administration of HG4 (5mg/kg) in mice led to almost complete inhibition of the lectin pathway activation for 48hrs, and 50% inhibition at 60hrs post administration. Inhibition of the lectin pathway in mice prior to LPS-induced lung injury improved all pathological markers tested. HG4 reduces the protein concentration in bronchoalveolar lavage fluid (p<0.0001) and levels of myeloid peroxide (p<0.0001), LDH (p<0.0001), TNFα and IL6 (both p<0.0001). Lung injury was significantly reduced (p<0.001) and the survival time of the mice increased (p<0.01). From the previous findings we concluded that inhibition of the lectin pathway has the potential to prevent ARDS pathology.
Competitive multicomponent anion exchange adsorption of proteins at the single molecule level (2017)

We use single molecule spectroscopy to study a multicomponent, competitive protein adsorption system. Fluorescently-labeled α-lactalbumin proteins are super-resolved adsorbing to cationic anion-exchange ligands in the presence of a competitor, insulin. We find that the competitor reduces the number of binding events by blocking ligands throughout the observed measurement time while the single-site adsorption kinetics are unchanged.
Genetic Analysis of Tyrosine Kinase Function in B Cell Development (1996)

B lymphopoiesis is regulated by multiple signals from stromal cell contact, soluble cytokines, antigen, and T helper cells. In vitro and biochemical experiments have implicated tyrosine kinases as key components of many of these signaling pathways. Genetic analysis of the role of these tyrosine kinases has been facilitated by recent advance in transgenic and gene targeting technology as well as by the identification of the genetic basis of several human and murine immune deficiencies. This review discusses the effect of gain and loss of function mutations of selected tyrosine kinases and their regulators and substrates on B cell development and function.
Miniaturized Scintillator Detector for in Vivo Dosimetry in HDR Brachytherapy (2022)

International audience
Arene-transition metal chemistry. 2. Hydrogenation of metal-arene and allylmetal-arene complexes (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTArene-transition metal chemistry. 2. Hydrogenation of metal-arene and allylmetal-arene complexesE. L. Muetterties, Howard Schaeffer, R. I. Mink, M. Y. Darensbourg, M. Millar, T. Groshens, and K. J. KlabundeCite this: Inorg. Chem. 1979, 18, 3, 883–884Publication Date (Print):March 1, 1979Publication History Published online1 May 2002Published inissue 1 March 1979https://pubs.acs.org/doi/10.1021/ic50193a076https://doi.org/10.1021/ic50193a076research-articleACS PublicationsRequest reuse permissionsArticle Views134Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis of Optically Active 2-(tert-Butyloxycarbonylamino)-4-dialkoxyphosphorylbutanoate Protected Isosteres ofO-Phosphonoserine for Peptide Synthesis (1988)

The preparation of (S)-2-(tert-butoxycarbonylamino) -4-dialkoxyphosphorylbutanoate from (S)-aspartic acid is described.
Macintosh OLE 2 programmer's reference (1994)

The definitive reference for intermediate to advanced programmers who want to use Object Linking and Embedding to fully exploit integration between Macintosh functions and applications, this book provides a must-have professional-level resource for both concepts and reusable code. Includes a CD-ROM with the complete, official OLE 2.01 for the Macintosh Software Developer's Kit from Microsoft.
LTI continuous time consensus dynamics with multiple and distributed delays (2013)

We study linear time invariant (LTI) continuous time consensus dynamics in the presence of bounded communication delays. Contrary to traditional Lyapunov based methods, we approach the problem using Fixed Point Theory. This method, allows us to create an appropriate complete functional metric space and through contraction mappings to establish the existence and uniqueness of a solution of this model. We explore the case of constant as well as distributed delays.
Faculty Opinions recommendation of X-ray snapshots of the maturation of an antibody response to a protein antigen. (2003)

The process whereby the immune system generates antibodies of higher affinities during a response to antigen (affinity maturation) is a prototypical example of molecular evolution. Earlier studies have been confined to antibodies specific for small molecules (haptens) rather than for proteins. We compare the structures of four antibodies bound to the same site on hen egg white lysozyme (HEL) at different stages of affinity maturation. These X-ray snapshots reveal that binding is enhanced, not through the formation of additional hydrogen bonds or van der Waals contacts or by an increase in total buried surface, but by burial of increasing amounts of apolar surface at the expense of polar surface, accompanied by improved shape complementarity. The increase in hydrophobic interactions results from highly correlated rearrangements in antibody residues at the interface periphery, adjacent to the central energetic hot spot. This first visualization of the maturation of antibodies to protein provides insights into the evolution of high affinity in other protein-protein interfaces. PMID: 12740607
Spinal infections. Diagnosis and treatment. (2000)

Spinal infections encompass a broad spectrum of pathology. Any element of the spine, the vertebrae, disks, surrounding soft tissues, potential spaces, or the cord itself may be involved solely, or more commonly, in combination. Staphylococcus aureus is the organism most frequently found, with Gram negative bacteria often cited in association with infections of the urinary tract and in intravenous drug abusers. Early diagnosis and treatment are essential for optimal outcomes. In some cases, the only necessary treatment consists of parenteral antibiotics and immobilization. However, certain instances require operative intervention. The goals of treatment for any infection of the spine are: early diagnosis with identification of the offending organism, preservation of neurological function or cessation of progressive neurologic deficit, and complete eradication of the infection with a pain-free, stable spine.
Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney (1994)

Electrically silent Na(+)-(K+)-Cl- transporter systems are present in a wide variety of cells and serve diverse physiological functions. In chloride secretory and absorbing epithelia, these cotransporters provide the chloride entry mechanism crucial for transcellular chloride transport. We have isolated cDNAs encoding the two major electroneutral sodium-chloride transporters present in the mammalian kidney, the bumetanide-sensitive Na(+)-K(+)-Cl- symporter and thiazide-sensitive Na(+)-Cl- cotransporter, and have characterized their functional activity in Xenopus laevis oocytes. Despite their differing sensitivities to bumetanide and thiazides and their different requirements for potassium, these approximately 115-kDa proteins share significant sequence similarity (approximately 60%) and exhibit a topology featuring 12 potential membrane-spanning helices flanked by long non-hydrophobic domains at the NH2 and COOH termini. Northern blot analysis and in situ hybridization indicate that these transporters are expressed predominantly in kidney with an intrarenal distribution consistent with their recognized functional localization. These proteins establish a new family of Na(+)-(K+)-Cl- cotransporters.
Expanding the Phenotypic spectrum of NAA10 -related neurodevelopmental syndrome and NAA15 -related neurodevelopmental syndrome (2022)

Abstract Amino-terminal (Nt-) acetylation (NTA) is a common protein modification, affecting 80% of cytosolic proteins in humans. The human essential gene, NAA10, encodes for the enzyme NAA10, which is the catalytic subunit in the N-terminal acetyltransferase A (NatA) complex, also including the accessory protein, NAA15. The full spectrum of human genetic variation in this pathway is currently unknown. Here we reveal the genetic landscape of variation in NAA10 and NAA15 in humans. Through a genotype-first approach, one clinician interviewed the parents of 56 individuals with NAA10 variants and 19 individuals with NAA15 variants, which were added to all known cases (N=106 for NAA10 and N=66 for NAA15 ). Although there is clinical overlap between the two syndromes, functional assessment demonstrates that the overall level of functioning for the probands with NAA10 variants is significantly lower than the probands with NAA15 variants. The phenotypic spectrum includes variable levels of intellectual disability, delayed milestones, autism spectrum disorder, craniofacial dysmorphology, cardiac anomalies, seizures, and visual abnormalities (including cortical visual impairment and microphthalmia). One female with the p.Arg83Cys variant and one female with an NAA15 frameshift variant both have microphthalmia. The frameshift variants located toward the C-terminal end of NAA10 have much less impact on overall functioning, whereas the females with the p.Arg83Cys missense in NAA10 have substantial impairment. The overall data are consistent with a phenotypic spectrum for these alleles, involving multiple organ systems, thus revealing the widespread effect of alterations of the NTA pathway in humans.
Influence of Water Transport Across Microscale Bipolar Interfaces on the Performance of Direct Borohydride Fuel Cells (2020)

Direct borohydride fuel cells (DBFCs) can operate at double the voltage of proton exchange membrane fuel cells (PEMFCs) by employing an alkaline NaBH4 fuel feed and an acidic H2O2 oxidant feed. The pH-gradient-enabled microscale bipolar interface (PMBI) facilitates the creation and maintenance of an alkaline environment at the anode and an acidic environment at the cathode for the borohydride oxidation and peroxide reduction reactions. However, given the need to dissociate water at the interface to ensure ionic conduction, PMBI can be efficient only when anion exchange ionomer (AEI) moieties enable fast water transport for autoprotolysis. Herein, a series of polynorbornene-based AEIs with a range of water uptake values are examined to unravel the optimum water uptake required to enable high performance DBFCs. The DBFC with PMBI configuration containing the optimal AEI composition delivers a current density of 302 mA cm–2 at 1.5 V and a peak power density of 580 mW cm–2 at 1 V. This AEI composition exhibits high hydroxide ionic conductivity of 90.7 mS cm–1 at 80 °C with an IEC of 2.01 mequiv g–1 and demonstrates impressive chemical stability by retaining 98.75% of its initial ionic conductivity after immersion into anolyte (3 M KOH and 1.5 M NaBH4) at 70 °C for 536 h.
Coping, methamphetamine, and HIV-1 (2005)

Abstract studies conducted with mostly White, HIV+ gay and bisexual men reported that escape avoidance coping was related to poor adjustment, whereas active positive coping was associated with better adjustment (Blaney et al. 1990; Namir et al. 1990; Nicholson and Long 1990; Reed et al. 1990; Wolfe et al. 1990). In more recent years, studies of coping and psychological adjustment have focused on larger and more diverse samples of HIV+ individuals, including gay and bisexual men, women, intravenous drug users, and ethnic minorities.