gebhart/patrepeval huggingface dataset:
Identification of serum microRNAs predicting the response to nivolumab in patients with advanced gastric cancer (2018)

Background: Recent studies have reported that serum microRNAs (miRNAs) are potentially useful cancer biomarkers. In patients with gastric cancer (GC), the efficacy of nivolumab (Nivo), a PD-1 inhibitor, was shown in a phase III study, but predictive biomarkers of Nivo for gastric cancer have not been found. We investigated whether serum miRNAs could be predictive markers of the efficacy of Nivo in GC. Methods: The subjects of this study were 20 patients who were enrolled in the phase III study (ONO-4538-12) and received Nivo 3 mg/kg IV Q2W at our institution. Expressions of 2565 miRNAs in the serum samples before and during treatment were analyzed using “3D-Gene” Human miRNA Oligo Chip (Toray Industries, Inc.). We explored miRNAs that were significantly associated with the treatment response using receiver operating characteristic analysis and Cox regression analysis. Results: Median progression-free survival (PFS) was 2.3 month, and partial response was achieved in four of the 20 patients who received Nivo. Serum samples before (n = 20) and 4 weeks after (n = 17) the treatment of Nivo were available. Two different miRNAs, one before and the other after treatment, were identifiedwhich were related to response to Nivo. AUC of miR-A identified before treatment was 0.88, whereas that of miR-B after the first treatment was 0.85. The overall response rate (ORR) was 44% (4/9) in miR-A-high patients and 0% (0/11) in miR-A-low patients. The ORR was 50% (4/8) in miR-B-high patients and 0% (0/9) in miR-B-low patients. Median PFS was 14.3 m (95%CI: N/A-35.1) in miR-A-high patients and 1.6 m (95%CI: 0.9-2.3) in miR-A–low patients (HR = 0.19, log rank: p = 0.01), and those were 5.6 m (95%CI: N/A-35.1) and 1.6 m (95%CI: 0.9-2.3) in miR-B-high patients (HR = 0.21, log rank: p = 0.01), respectively. Conclusions: The two miRNAs in GC pts may be a predictive marker for identifying pts who derived greater benefit from Nivo therapy. Legal entity responsible for the study: Ken Kato. Funding: Has not received any funding. Disclosure: S. Takizawa: Personal fees: Toray Industries, Inc., outside the submitted work. O. Takahiro: Grants: Kewpie Corporation, Takeda, BioMimetics Sympathies, Rohto Pharmaceutical Co., Ltd., Inter Stem, Japan Atherosclerosis Research Foundation, Ono Pharmaceutical Co., Ltd., Daiichi-Sankyo Company. All other authors have declared no conflicts of interest.
ChemInform Abstract: Synthesis, Conformation, and Biological Activity of Teleocidin Mimics, Benzolactams. A Clarification of the Conformational Flexibility Problem in Structure‐Activity Studies of Teleocidins. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Temperature dependence of TIP3P, SPC, and TIP4P water from NPT Monte Carlo simulations: Seeking temperatures of maximum density (1998)

Monte Carlo statistical mechanics simulations have been carried out with the TIP3P, SPC, and TIP4P models for liquid water at 13 temperatures from −50°C to 100°C at 1 atm. Long runs with 512 water molecules provided definitive results for densities. Although the TIP4P model yields a flat region in the density profile and a temperature of maximum density near −15°C, the SPC and TIP3P models show monotonically increasing density with decreasing temperature. Results for heats of vaporization, isothermal compressibilities, and coefficients of thermal expansion and their convergence characteristics are also reported. © 1998 John Wiley & Sons, Inc. J Comput Chem 19: 1179–1186, 1998
Isolation of an Active Fragment of Protein Phosphatase Inhibitor-1 from Rabbit Skeletal Muscle (1978)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
Low alpha-synuclein levels in the blood are associated with insulin resistance (2015)

Mutations in the protein alpha-synuclein (SNCA) have been linked to Parkinson's disease. We recently reported that non-mutated SNCA enhanced glucose uptake through the Gab1-PI3 kinase-Akt pathway and elucidated its effects on glucose regulation. Here, we examined the association of SNCA with insulin resistance (IR), a condition that is characterized by decreased tissue glucose uptake. Our observations include those from a population study as well as a SNCA-deficient mouse model, which had not previously been characterized in an IR scenario. In 1,152 patients, we found that serum SNCA levels were inversely correlated with IR indicators--body mass index, homeostatic model assessment for IR (HOMA-IR) and immunoreactive insulin (IRI)--and, to a lesser extent, with blood pressure and age. Additionally, SNCA-deficient mice displayed alterations in glucose and insulin responses during diet-induced IR. Moreover, during euglycemic clamp assessments, SNCA knock-out mice fed a high-fat diet (HFD) showed severe IR in adipose tissues and skeletal muscle. These findings provide new insights into IR and diabetes and point to SNCA as a potential candidate for further research.
Synthesis and Characterization of Sr2Cu(W1–xMox)O6: A Quasi-Two-Dimensional Magnetic System (2012)

Here, we report the synthesis of the double-perovskite system Sr2Cu(W1–xMox)O6, with x = 0.0–1.0, where the Mo-containing members have not been synthesized before. This system provides an example of a quasi-two-dimensional S = 1/2 square lattice, with the possibility of magnetic frustration. The compounds were synthesized under ambient pressure for 0 ≤ x ≤ 0.6 and under high pressure (HP) for 0.7 ≤ x ≤ 1.0. A small percentage of impurities, primarily Sr(W,Mo)O4, was present in all samples and increased for x ≥ 0.5. Tetragonal distortion of the compounds decreases with increasing x, and correspondingly, a first-order tetragonal-cubic cooperative Jahn–Teller ordering of the 3d hole on the CuII into dx2–y2 orbitals below a TJT ≈ 920 °C in Sr2CuWO6 is lowered to a TJT ≈ 500 °C in Sr2CuMoO6. The samples were all insulators, but the band gap was found to decrease with increasing Mo content due to the weaker Mo 4d–O 2p hybridization compared to that of W 5d–O 2p. Ordering of the CuII holes into dx2–y2 orbitals creates magnetic interactions between spins S = 1/2 with antiferromagnetic 180° Cu–O–(W,Mo)–O–Cu parameters (−J2) and ferromagnetic 90° Cu–O–(W,Mo)–O–Cu parameters (+J1) in the (001) planes. Magnetic susceptibility showed no long-range magnetic order in any sample down to 5 K.
Antibody Molecules Discriminate between Crystalline Facets of a Gallium Arsenide Semiconductor (2006)

Seamless integration of biomolecules with manmade materials will most likely rely on molecular recognition and specific binding. In the following we show that combinatorial antibody libraries, based on the vast repertoire of the human immune system, can be harnessed to generate such binders. As a demonstration, we isolate antibody fragments that discriminate and bind selectively GaAs (111A) facets as opposed to GaAs (100). The isolated antibodies are utilized for exclusive localization of a fluorescent dye on (111A) surfaces in a structure comprising a mixture of (100) and (111A) surfaces. The potential importance of structure rigidity to facet recognition is suggested vis-a-vis published experiments with short and longer peptides.
The MATE survey: men's perceptions and attitudes towards menopause and their role in partners’ menopausal transition (2019)

Overall, men are aware of their partner's menopausal transition and may influence decisions relating to symptom management. Educational interventions would further benefit men's awareness of menopause and available treatment options.Video Summary:http://links.lww.com/MENO/A424.
A Comprehensive Study on Oxygen Reduction and Evolution from Lithium Containing DMSO Based Electrolytes at Gold Electrodes (2016)

In the present study, we investigated the reduction and the evolution of oxygen from lithium containing DMSO based electrolytes at gold. The number of electrons that are transferred per O2 (z-value) during oxygen reduction depends on the structure of the electrode: Despite the presence of Li+, O2 is reduced electrochemically to superoxide at smooth gold electrodes and at low overpotentials. At porous electrodes a z-value close to 2 e−/O2 indicates Li2O2-formation even at low overpotentials. This is ascribed to a reaction of superoxide, which is catalyzed by gold-particles at open circuit. This behavior is also responsible for the non-proportionality between reduced and evolved amounts of oxygen. Furthermore, we observed a linear relationship between evolved amounts of CO2 and reduced amounts of oxygen, indicative for electrolyte decomposition during oxygen reduction. Combined electrochemical quartz crystal microbalance (eQCMB) and Differential electrochemical mass spectroscopy (DEMS) measurements reveal that mass changes that occur in the anodic sweep are due to the evolution of CO2, whereas oxygen evolution takes place without any mass changes. The observed m.p.e-values (mass changes per transferred electron) are affected by convection due to the formation of soluble reduction products which observed in rotating ring disc electrode measurements.
Elastic scattering by planar fractures (2011)

Remote sensing of fractures with elastic waves is important in fields ranging from seismology to non‐destructive testing. While previous analytic descriptions of scattering mostly concern very large or very small fractures (compared to the dominant wavelength), we present an analytic solution for the scattering of elastic waves from a fracture of arbitrary size. Based on the linear‐slip model for a fracture, we derive the scattered amplitude in the frequency domain under the Born approximation for all combinations of incident and scattered wave modes. Our analytic results match laser‐based ultrasonic laboratory measurements of a single fracture in clear plastic, allowing us to quantify the compliance of a fracture.
A New Method for Acid Stimulation without Increasing Water Production: Case Studies from Offshore Mexico (2006)

Abstract Successful acid stimulation requires a method to distribute the acid between multiple hydrocarbon zones. Since almost all producing wells are inhomogeneous, containing sections of varying permeability, this can be a huge problem. In addition, the water saturation of the various zones plays an important role. Since acid is an aqueous fluid, it will tend to predominantly enter the zones with the highest water saturation. These water zones are also often the highest permeability zones, so acid stimulation will often result in large increases in water production. There are many negative aspects to increased water production, such as increased lifting and disposal costs, increased corrosion, etc. This paper describes the use of a new low viscosity system that inherently reduces formation permeability to water with little effect on hydrocarbon permeability, and also diverts acid from high permeability zones to lower permeability zones. This new system has been used in offshore Mexico in the Chuc, Caan, and Pol fields among others over the past year. During this time, over 30 wells have been treated with the new system. Most standard acid treatments in this field result in increased hydrocarbon and water production. The new system has resulted in increased hydrocarbon production with no increase in water production, and in some cases a decrease in water production. Details from several of these jobs will be presented showing the diversion and production results.
Growth of Newborn, Term Infants Fed Soy Formulas For 1 Year (1999)

Few studies have measured long-term growth in infants fed soy protein-based formulas. The effect of nucleotide (NT) supplementation of soy protein-based infant formulas on growth is unknown. Growth was therefore evaluated in healthy term infants fed a soy protein-based formula (SOY; n = 73), SOY with added NT (72 mg added NT/L) at human milk (HM) levels (SOYN, n = 73), or mixed feeding (MF, n = 67) in a randomized, masked, parallel 1-year feeding study. The MF group (a nonrandomized reference group) was fed HM exclusively from birth to 2 months of age followed by HM and/or a standard milk-based formula (Similac with Iron with no supplemental NTs) to 1 year of age. Results indicated that growth (weight, length, and head circumference) was normal and comparable among the three groups. All three groups had similar plasma albumin (at 2 months of age) and hemoglobin levels (at 12 months of age). Thus, this study demonstrated similar growth in the first year of life among infants fed MF feeding or soy formula with or without supplemental NTs.
Direct curvature correction for noncontact imaging modalities applied to multispectral imaging (2010)

Noncontact optical imaging of curved objects can result in strong artifacts due to the object's shape, leading to curvature biased intensity distributions. This artifact can mask variations due to the object's optical properties, and makes reconstruction of optical/physiological properties difficult. In this work we demonstrate a curvature correction method that removes this artifact and recovers the underlying data, without the necessity of measuring the object's shape. This method is applicable to many optical imaging modalities that suffer from shape-based intensity biases. By separating the spatially varying data (e.g., physiological changes) from the background signal (dc component), we show that the curvature can be extracted by either averaging or fitting the rows and columns of the images. Numerical simulations show that our method is equivalent to directly removing the curvature, when the object's shape is known, and accurately recovers the underlying data. Experiments on phantoms validate the numerical results and show that for a given image with 16.5% error due to curvature, the method reduces that error to 1.2%. Finally, diffuse multispectral images are acquired on forearms in vivo. We demonstrate the enhancement in image quality on intensity images, and consequently on reconstruction results of blood volume and oxygenation distributions.
Organizational aspects: developing policies and procedures for continuous renal replacement therapies (2009)

Abstract Chapter 27 discusses the process of developing a continuous renal replacement therapy (CRRT) program and how to avoid the pitfalls that frequently confront newly growing CRRT programs.
Planning and realization of orthopedic surgery with the aid of individual templates (2000)

Operational interventions can be planned and simulated accurately with the help of a three-dimensional reconstruction of the anatomical bone structures, created from the tomographic data of a patient. Computer-assisted navigation systems or robotic systems can assist the intraoperative realization of the planned intervention and may support the spatial orientation within the operational field. As an inexpensive alternative without the high excessive technical workload on the physicians or the surgical personnel, individual templates were developed in the Helmholtz Institute Aachen. In this approach the negative three-dimensional bone surface, known exactly from the 3D-reconstruction of the patient's bone by the planning system DISOS, is milled into a small cubic block of polycarbonate. During the intervention, the template serves as a reference for the spatial orientation and as a tool-guide for cutting or milling of the bone according to the previous planning. Clinical and experimental studies have shown that operation times as well as intraoperative X-ray times can be shortened by the use of individual templates, while preserving the task sequence of the conventional operation procedures.
Quantification of the contribution of the paretic and non paretic leg in balance control of stroke patients (2004)

Keywords: balance control, stroke, system identification
Demonstration of a forward iterative method to reconstruct brachytherapy seed configurations from x-ray projections (2005)

By monitoring brachytherapy seed placement and determining the actual configuration of the seeds in vivo, one can optimize the treatment plan during the process of implantation. Two or more radiographic images from different viewpoints can in principle allow one to reconstruct the configuration of implanted seeds uniquely. However, the reconstruction problem is complicated by several factors: (1) the seeds can overlap and cluster in the images; (2) the images can have distortion that varies with viewpoint when a C-arm fluoroscope is used; (3) there can be uncertainty in the imaging viewpoints; (4) the angular separation of the imaging viewpoints can be small owing to physical space constraints; (5) there can be inconsistency in the number of seeds detected in the images; and (6) the patient can move while being imaged. We propose and conceptually demonstrate a novel reconstruction method that handles all of these complications and uncertainties in a unified process. The method represents the three-dimensional seed and camera configurations as parametrized models that are adjusted iteratively to conform to the observed radiographic images. The morphed model seed configuration that best reproduces the appearance of the seeds in the radiographs is the best estimate of the actual seed configuration. All of the information needed to establish both the seed configuration and the camera model is derived from the seed images without resort to external calibration fixtures. Furthermore, by comparing overall image content rather than individual seed coordinates, the process avoids the need to establish correspondence between seed identities in the several images. The method has been shown to work robustly in simulation tests that simultaneously allow for unknown individual seed positions, uncertainties in the imaging viewpoints and variable image distortion.
Proceedings of the 3rd IMechE Automobile Division Southern Centre Conference on Total vehicle technology : finding the radical, implementing the practical, 26-27th April 2004, University of Sussex, Brighton, UK (2004)

About the Editors.Preface.Vehicle Dynamics and Control.Vehicle Safety.Human-Centered Design.Developing Vehicle Propulsion for the Environment.Vehicle Design.Experimental Techniques.Control Systems Technology.Author's Index.
A First RF Digitally-Controlled Oscillator for SAW-less TX in Cellular Systems (2005)

A first digitally-controlled oscillator for mobile stations is presented. Combining a MTM capacitor and two NMOS transistor arrays for the varactor as an RF DAC, a highly linear oscillator gain is achieved, and is insensitive to process shift. With a sigma-delta dithering, a fine frequency resolution is obtained while having negligible phase noise degradation. The measured -167dBc/Hz at 20MHz offset from 915MHz carrier proves that this DCO system can be used in a SAWless transmitter for mobile phones.
Pubertal changes in HOMA and QUICKI: relationship to hepatic and peripheral insulin sensitivity (2004)

Abstract: Background: Homeostasis model assessment (HOMA) and quantitative insulin-sensitivity check index (QUICKI) are measures of insulin resistance and insulin sensitivity derived from fasting glucose (FG) and insulin levels. They thus should reflect, in principle, insulin action on both the liver and the periphery. Methods: Twenty-three prepubertal and early pubertal adolescents were studied at baseline and after 6 months, using the frequently sampled intravenous glucose tolerance test (IVGTT) with labeled glucose. Total body insulin sensitivity (SI) was calculated using the minimal model and total glucose concentrations. Peripheral insulin sensitivity (SI*) was calculated from labeled glucose concentrations. Hepatic insulin resistance (HIR) was calculated by multiplying glucose production over the last hour by the average insulin level. HOMA and QUICKI were calculated from the fasting glucose and insulin values. Results: HOMA, QUICKI fasting insulin, and glucose to insulin ratio were all significantly related to SI (p < 0.05) but were not independently related to SI* or HIR. Multiple linear regression analysis revealed that both SI* and HIR independently predicted HOMA and fasting glucose (p < 0.1). QUICKI, fasting insulin, and glucose to insulin ratio were not independently related to SI, SI*, or HIR. Conclusions: HOMA and fasting insulin reflect total body insulin sensitivity and HIR but not peripheral insulin sensitivity in prepubertal and early pubertal adolescents.
Study on Mineral Processing Flowsheet of a Certain Low Grade Pb-Zn Sulphide Ores (2011)

In light of the characteristics of Pb-Zn sulphide ores with fine dissemination size, close intergrowth and contain large number of slime,a new flotation flowsheet is containing lead preferential flotation,ammonium dibutyl dithiophosphate as collector,Na 2 CO 3 as pH modifiers, and ZnSO 4 as depressor. Then zinc is recovered by using CuSO 4 as activator, butyl xanthate as collector, successfully realizing the separation of lead and zinc .The grade of lead concentration is 50.60％,containing 3.93％Zn. The recovery of lead is 87.78％.In addition, the grade of zinc concentration is 47.75％, containing 0.48％Pb and the recovery of zinc is 88.58％.
Silicon slow-light-based photonic mixer for microwave-frequency conversion applications (2012)

We describe and demonstrate experimentally a method for photonic mixing of microwave signals by using a silicon electro-optical Mach-Zehnder modulator enhanced via slow-light propagation. Slow light with a group index of ~11, achieved in a one-dimensional periodic structure, is exploited to improve the upconversion performance of an input frequency signal from 1 to 10.25 GHz. A minimum transmission point is used to successfully demonstrate the upconversion with very low conversion losses of ~7 dB and excellent quality of the received I/Q modulated QPSK signal with an optimum EVM of ~8%.
Electrically Reconfigurable Nonvolatile Metasurface Using Optical Phase Change Materials (2019)

We report what we believe to be the first electrically reconfigurable metasurface based on chalcogenide phase change materials. Multi-cycle reversible switching was realized using onchip micro-heaters. Quasi-continuous resonance tuning over half an octave were demonstrated.
Inhibition of Human Retinal Pigment Epithelial Cell Attachment, Spreading, and Migration by Alkylphosphocholines (2005)

APCs inhibit RPE cell attachment and spreading in vitro at nontoxic concentrations. As a possible mechanism of action, APCs disturb microfilament assembly, since they are known to interfere with protein kinase C (PKC) function. This could represent a novel method of preventing even early stages of proliferative vitreoretinal diseases like proliferative vitreoretinopathy (PVR).
Copper-Catalyzed Asymmetric Allylic Substitution with Arylaluminum Reagents (2011)

This work describes a highly efficient enantioselective allylic substitution of allyl phosphates. The reaction is catalyzed by an in situ generated copper-NHC complex and employs nucleophilic arylaluminum reagents, which are conveniently prepared from the corresponding aryllithium reagent. Chiral quaternary stereogenic centers are produced from readily available starting materials.