gebhart/patrepeval huggingface dataset:
Circulating tumor DNA (ctDNA) as a marker of residual disease and recurrence in resected stage I-IV epithelial ovarian cancer (EOC). (2023)

5553 Background: The management of EOC remains challenging, with a high risk of relapse despite surgery, chemotherapy and maintenance therapy. Detection of ctDNA after surgery and adjuvant chemotherapy (CT) may identify patients (pts) at highest risk of recurrence suitable for treatment escalation. Our primary aim was to investigate the use of ctDNA as a marker of residual disease following both surgery and adjuvant CT that might predict later recurrence. Methods: In this multi-centre observational study, we collected blood samples post-op and 6-8 weeks post-CT completion from pts with debulked stage I-IV EOC planned for adjuvant CT. Pre-cycle 1 CT and pre-op blood was also collected from some pts who received neoadjuvant CT. We used a tumor-informed approach for ctDNA analysis with whole exome sequencing of tumor tissue followed by detection of up to 50 variants in the plasma with the SaferSeqS assay. The primary outcome was recurrence-free survival (RFS), calculated using the Cox proportional-hazards model. Results: 81 pts who had post-op ctDNA results were included. 84% had high grade serous histology and 23% had BRCA mutations. Median number of tumor-informed variants analyzed in the plasma was 44 (range 3-60). Overall, post-operative ctDNA was detected in 63 of 81 (78%) of pts, 18 of 26 (69%) in Stage I-II and 45 of 55 (82%) in Stage III-IV. Pts who were ctDNA negative post-surgery had longer RFS versus who were ctDNA positive (HR 3.28, 95% CI 1.39 to 7.72, p = 0.007). Estimated RFS at 2 years was 78% among pts who were ctDNA negative post-surgery and 44% among the ctDNA positive group. Pts with BRCA mutations were less likely to have positive post op ctDNA (OR 0.12, 95% CI 0.036 to 0.39, p &lt; 0.001). For post-CT ctDNA, estimated RFS at 2 years was 74% in the ctDNA negative pts versus 43% in the ctDNA positive group but this was not statistically significant (HR 1.64, 95% CI 0.84 to 3.18, p = 0.15). Pts with zero residual disease were more likely to be ctDNA negative post-surgery (OR 12.36, 95% CI 1.54 to 99.4, p = 0.018). Post-op ctDNA outperformed post-op CA-125 in predicting recurrence; pts with elevated CA-125 post-surgery had shorter RFS compared to those with normal CA-125 post-surgery (HR 1.99, 95% CI 1.15 to 3.42, p = 0.013). Of 18 pts who had neoadjuvant CT, pre-treatment ctDNA was detected in 17 (94%). Only two pts had clearance of ctDNA post neoadjuvant CT and both had zero residual disease at surgery. For the pts that maintained positive ctDNA results post-op, 7/15 (47%) pts had zero residual disease. Conclusions: ctDNA detection after ovarian cancer cytoreduction identifies pts at very high risk of recurrence. Pts with BRCA mutations were more likely to have negative ctDNA post-op. The role of ctDNA in guiding neoadjuvant and adjuvant therapy to improve outcomes, warrants further investigation. Clinical trial information: ACTRN12617001119381 .
Robust self-tuning speed servo system for wide speed range based on instantaneous speed observer and disturbance observer (2002)

This paper proposes a new robust self-tuning speed servo system for a wide speed reference which is based on the instantaneous speed observer and the disturbance observer. In order to regulate a motor speed for a wide speed reference including a very low speed range, this paper designs the instantaneous speed observer which uses the information of an armature current and an armature voltage. The proposed observer takes account of both the resistance variation and the forward voltage drop. Moreover, for the purpose of realizing the robust speed control, this paper constructs the disturbance observer mounted with the inertia identification algorithm and the self-tuning I-P speed controller. The total system becomes the robust self-tuning speed servo system for a wide speed range.
Quantized Ballistic Transport of Electrons and Electron Pairs in\n LaAlO$_3$/SrTiO$_3$ Nanowires (2016)

SrTiO$_3$-based heterointerfaces support quasi-two-dimensional (2D) electron\nsystems that are analogous to III-V semiconductor heterostructures, but also\npossess superconducting, magnetic, spintronic, ferroelectric, and ferroelastic\ndegrees of freedom. Despite these rich properties, the relatively low\nmobilities of 2D complex-oxide interfaces appear to preclude ballistic\ntransport in 1D. Here we show that the 2D LaAlO$_3$/SrTiO$_3$ interface can\nsupport quantized ballistic transport of electrons and (non-superconducting)\nelectron pairs within quasi-1D structures that are created using a\nwell-established conductive atomic-force microscope (c-AFM) lithography\ntechnique. The nature of transport ranges from truly single-mode (1D) to\nthree-dimensional (3D), depending on the applied magnetic field and gate\nvoltage. Quantization of the lowest $e^2/h$ plateau indicate a ballistic\nmean-free path $l_{MF}\\sim$ 20 $\\mu$m, more than two orders of magnitude larger\nthan for 2D LaAlO$_3$/SrTiO$_3$ heterostructures. Non-superconducting electron\npairs are found to be stable in magnetic fields as high as $B=11$ T, and\npropagate ballistically with conductance quantized at 2$e^2/h$. Theories of\none-dimensional (1D) transport of interacting electron systems depend crucially\non the sign of the electron-electron interaction, which may help explain the\nhighly ballistic transport behavior. The 1D geometry yields new insights into\nthe electronic structure of the LaAlO$_3$/SrTiO$_3$ system and offers a new\nplatform for the study of strongly interacting 1D electronic systems.\n
Wave height guided multishot receiver deghosting (2016)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2016Wave height guided multishot receiver deghostingAuthors: Gordon PooleSimon KingGordon PooleCGG and Simon KingCGGhttps://doi.org/10.1190/segam2016-13913344.1 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Abstract Many hydrophone only receiver deghosting algorithms make a flat sea surface assumption. In the case of significant ocean swell a variable free-surface datum is imposed and this assumption will not be met, resulting in degraded results. We extend a multi-shot receiver deghosting approach that satisfies the recorded primary and ghost wavefields by incorporating the presence of a variable free-surface at the source and receiver sides. The approach derives a τ-psht-prec model of the data at mean free-surface datum to estimate and remove the ghost. The approach is shown to produce high resolution receiver deghosting results with improved spatial consistency on a variable-depth streamer dataset from the North Sea. Presentation Date: Wednesday, October 19, 2016 Start Time: 8:00:00 AM Location: 140 Presentation Type: ORAL Keywords: broadband, decomposition, signal processing, sparse, time-domainPermalink: https://doi.org/10.1190/segam2016-13913344.1FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 2016ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2016 Pages: 5654 publication data© 2016 Published in electronic format with permission by the Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 01 Sep 2016 CITATION INFORMATION Gordon Poole and Simon King, (2016), "Wave height guided multishot receiver deghosting," SEG Technical Program Expanded Abstracts : 4730-4734. https://doi.org/10.1190/segam2016-13913344.1 Plain-Language Summary Keywordsbroadbanddecompositionsignal processingsparsetime-domainPDF DownloadLoading ...
Equivalence of Kröner and weighted Voigt-Reuss models for x-ray stress determination (2013)

The determination of stress in polycrystalline aggregates by diffraction-based methods relies on the proper choice of grain interaction model that links the observed strain to the elastic stress state in the ensemble. It is shown that for single-phase, polycrystalline samples composed of crystals with cubic symmetry, x-ray elastic constants (XEC) calculated under the Kröner model are equal to those from a weighted combination of Reuss and Voigt XEC, where the weighting factor is only a function of the single crystal elastic tensor coefficients. This weighting factor, xKr, generally scales with elastic anisotropy factor, A, with a value close to the Neerfeld limit for elastically isotropic materials (A = 1). Materials that possess large values of A, and correspondingly small xKr, exhibit a greater deviation between the Neerfeld and Kröner limit XEC. A dimensionless parameter, Q, based on a different combination of elastic coefficients than A, demonstrates a monotonic trend with respect to xKr and may serve as a better metric for describing the elastic response of a polycrystalline ensemble as interrogated by x-ray diffraction. For crystals possessing lower symmetry, a similar analysis reveals that Kröner XEC are not a unique combination of Voigt and Reuss limits. In the case of hexagonal crystal symmetry, xKr for a particular material varies as a function of the orientation parameter of the crystal, indicating that the degree of elastic anisotropy of the constituent crystals may impact the determination of stress depending on the choice of x-ray reflection.
Interfacial Tension of Polyelectrolyte Complex Coacervate Phases (2014)

We consider polyelectrolyte solutions which, under suitable conditions, phase separate into a liquid-like coacervate phase and a coexisting supernatant phase that exhibit an extremely low interfacial tension. Such interfacial tension provides the basis for most coacervate-based applications, but little is known about it, including its dependence on molecular weight, charge density, and salt concentration. By combining a Debye-Hückel treatment for electrostatic interactions with the Cahn-Hilliard theory, we derive explicit expressions for this interfacial tension. In the absence of added salts, we find that the interfacial tension scales as <i>N</i><sup>-3/2</sup>(η/η<sub>c</sub>-1)<sup>3/2</sup> near the critical point of the demixing transition, and that it scales as η<sup>1/2</sup> far away from it, where <i>N</i> is the chain length and η measures the electrostatic interaction strength as a function of temperature, dielectric constant, and charge density of the polyelectrolytes. For the case with added salts, we find that the interfacial tension scales with the salt concentration ψ as <i>N</i><sup>-1/4</sup>(1-ψ/ψ<sub>c</sub>)<sup>3/2</sup> near the critical salt concentration ψ<sub>c</sub>. Our predictions are shown to be in quantitative agreement with experiments and provide a means to design new materials based on polyelectrolyte complexation.
Investigation on reliability of red micro-light emitting diodes with atomic layer deposition passivation layers (2020)

In this study, AlGaInP red light emitting diodes with sizes ranging from 5 to 50 micrometers were fabricated and characterized. The atomic layer deposition technology is applied to coat a layer of silicon dioxide for passivation and protection. The top emission area is covered by ITO layer to maximize the optical output. From the optical measurement, the linewidth and emission peaks shift very little among different current levels (from 30 to 150 A/cm<sup>2</sup>). High current level lifetests are performed and a 15 µm ALD device can last 27 hours of continuous operation at 100 A/cm<sup>2</sup> before their diode junction failed. A much shorter lifetime of 5.32 hours was obtained when the driving current is raised to 400 A/cm<sup>2</sup>. When the same condition was applied to 15 µm PECVD devices, 25 hours and 4.33 hours are registered for 100 A/cm<sup>2</sup> and 400 A/cm<sup>2</sup> tests, respectively. The cross-sectional SEM reveals the voids, defects, and dark lines developed during the aging tests, and most of them are caused by top contact failure. The surface layers of ITO and SiO<sub>2</sub> were melted and the dark lines which were originated from the top surface propagated through the device and led to the eventual failure of the diode. The optical intensity degradation slopes of different sizes of devices indicate a large device can last longer in this accelerated aging test. The efficiencies of the devices are also evaluated by the ABC model and the fitted bimolecular coefficient ranges from 1.35 to 3.40×10<sup>-10</sup> cm<sup>3</sup>/s.
Transgene by germplasm interactions can impact transgene evaluation (2023)

Abstract Transgenes have been successfully commercialized for qualitatively inherited insect and herbicide resistance traits that show similar effects across genetic backgrounds. However, for quantitative traits like yield, genetic background may affect the measured transgene value. In this paper, we evaluated whether different genetic backgrounds impact the estimated value of a transgene for grain yield, plant height, and anthesis‐silking interval for maize by developing isogenic pairs of lines with and without a transgene and testing them in hybrid combination with non‐transgenic lines from a complementary heterotic group across eleven environments in the United States. Over all hybrid combinations, the transgene increased yield by 0.2 Mg ha −1 . Across multiple non‐transgenic lines of the opposing heterotic group, the transgene effect within a line pair ranged from an increase of 0.8 Mg ha −1 for the NSS4 (non‐stiff stalk) and SS7 (stiff stalk) transgenic lines to a reduction of 0.3 Mg ha −1 for the NSS5 transgenic line when compared to their non‐transgenic isoline. Transgenic hybrids were often taller than non‐transgenic hybrids ( p &lt; 0.05). Anthesis to silking interval was reduced by four growing degree days overall, but no transgene × genotype interaction was detected among line pairs. Our results show the importance of testing transgene efficacy across a large sample of elite hybrid pairs to assess the gene's value. By only testing in a specific hybrid background, as may be done for qualitative traits like insect resistance, transgenes could be erroneously advanced or eliminated.
1385: Significant Variation in BPH-Surgical Rates Explained by Medical Therapy Rates, Health Resources and Sociodemograpidc Factors (2005)

You have accessJournal of UrologyPodium, Tuesday, May 24, 2005, 3:30 - 5:30 pm1 Apr 20051385: Significant Variation in BPH-Surgical Rates Explained by Medical Therapy Rates, Health Resources and Sociodemograpidc Factors W. Patrick Springhart, Roger L. Sur, Charles D. Scales, Regina D. Norris, Jeffrey C. Sung, Glenn M. Preminger, and David M. Albala W. Patrick SpringhartW. Patrick Springhart More articles by this author , Roger L. SurRoger L. Sur More articles by this author , Charles D. ScalesCharles D. Scales More articles by this author , Regina D. NorrisRegina D. Norris More articles by this author , Jeffrey C. SungJeffrey C. Sung More articles by this author , Glenn M. PremingerGlenn M. Preminger More articles by this author , and David M. AlbalaDavid M. Albala More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)35519-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1385: Significant Variation in BPH-Surgical Rates Explained by Medical Therapy Rates, Health Resources and Sociodemograpidc Factors." The Journal of Urology, 173(4S), p. 376 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 376 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information W. Patrick Springhart More articles by this author Roger L. Sur More articles by this author Charles D. Scales More articles by this author Regina D. Norris More articles by this author Jeffrey C. Sung More articles by this author Glenn M. Preminger More articles by this author David M. Albala More articles by this author Expand All Advertisement PDF downloadLoading ...
Novel 5V-EDMOS transistor with a record /max of 450 GHz in a baseline 40nm CMOS technology (2017)

A novel EDMOS device with a breakdown voltage of ∼10V and a record high RF performance, with f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> ∼ 90 GHz and /MAX ∼ 450 GHz, is presented. The transistor is composed of a thin gate oxide (logic) in the channel and a thicker oxide (IO) in the drain extension. A separate dummy gate is formed on the extension region to optimize the electric field for minimizing the device degradation due to the hot carrier injection. The device concept has been intensively investigated by TCAD, and fabricated in a baseline 40nm CMOS foundry process without any additional masks. This paper discusses in detail the measured characteristics of the device, including DC, RF and the reliability. For the same operating and breakdown voltage, this device outperforms optimized Si-LDMOS and SiGe HBTs in both f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> and f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Max</inf> , and is on par with the best-in-class GaN-HEMTs in term of f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Max</inf> .
A Wireless Optical Position Sensing and Communications System for a Locking Differential (2021)

We present an optical sensing and communication system that enables remote instrumentation in the extreme environment of a locking automotive differential. The sensor is used to measure the linear position of internal locking hardware to determine the locking state of the differential. The prototype solution is fabricated using 3D printing and makes use of optical waveguides for increased reading and transmission reliability. The device uses infrared to effectively sense the position of the locking plate and transmits the locking status at 100 Hz. Our solution introduces a broad class of wireless sensing systems for use in the automotive industry.
Re: Is PAWP the ′real′ sperm factor? (2014)

Mammalian embryo development is init iated by intracel lular Ca2+ oscillations that result in oocyte activation following gamete membrane fusion. It is widely believed that oocyte Ca2+ oscillations are triggered by a sperm-specific protein, phospholipase C-zeta (PLCζ) that activates InsP3 production leading to repetitive Ca2+ release from intracellular stores. However, a recent report in the FASEB Journal by Aarabi et al. challenges this view by proposing postacrosomal WW domain-binding protein (PAWP) as another sperm-derived protein that can also initiate Ca2+ oscillations and zygotic development at fertilization. Here we discuss these new findings and examine the evidence suggesting PAWP as the "real" sperm factor.
Analysis of static and time-varying polarization errors in the multiangle spectropolarimetric imager (2011)

Multiangle Spectropolarimetric Imager (MSPI) sensitivity to static and time-varying polarization errors is examined. For a system without noise, static polarization errors are accurately represented by the calibration coefficients, and therefore do not impede correct mapping of measured to input Stokes vectors. But noise is invariably introduced during the detection process, and static polarization errors reduce the system's signal-to-noise ratio (SNR) by increasing noise sensitivity. Noise sensitivity is minimized by minimizing the condition number of the system data reduction matrix [Appl. Opt.41, 619 (2002)]. The sensitivity of condition numbers to static polarization errors is presented. The condition number of the nominal MSPI data reduction matrix is approximately 1.1 or less for all fields. The increase in the condition number above 1 results primarily from a quarter wave plate and mirror coating retardance magnitude errors. Sensitivity of the degree of linear polarization (DoLP) error with respect to time-varying diattenuation and retardance error was used to set a time-varying diattenuation magnitude tolerance of 0.005 and a time-varying retardance magnitude tolerance of ±0.2°. A Monte Carlo simulation of the calibration and measurements using anticipated static and time-varying errors indicates that MSPI has a probability of 0.9 of meeting its 0.005 DoLP uncertainty requirement.
Label-free, single molecule detection of cytokines using optical microcavities (2007)

Interleukin-2 (IL2) is a cytokine that regulates T-cell growth and is used in cancer therapies. By sensitizing a microcavity sensor surface with anti-IL2 and monitoring the resonant frequency, single molecules of IL2 can be detected.
Terahertz spectroscopy analysis of human corneal sublayers (2021)

The hydration concentration from stromal layer was further quantitatively calculated. At the end of the experiment, all the corneal hydration levels reach to the same value which shows that the edema hydration has reached maximum saturation. The information of individual sublayers of the cornea is obtained by characterizing noninvasively with the use of THz spectroscopy. To our knowledge, this is the first report of using THz for noninvasive characterization of sublayers of the cornea.
Microwave photonic applications of MEMS technology (2003)

We describe RF MEMS switches and their applications to tunable filters and switchable antenna elements. We describe different scenarios where RF photonic systems can benefit from RF MEMS device development.
Inhibitory Effect of Sulfur&ndash;containing Compounds on Anodic Oxidation of Borohydride (2016)

Inhibitory effect of sulfur–containing compounds on anodic oxidation of borohydride was investigated. The linear sweep voltammetry technique revealed that sulfur compounds such as thiosulfate and sulfide inhibited anodic oxidation of borohydride not only on a platinum surface but also on a glassy carbon surface which had less catalytic activity of borohydride electro–oxidation. Through electrochemical impedance spectroscopy, it was confirmed the charge transfer resistance of borohydride oxidation at the electrode surface increased in the presence of sulfur compounds, but the capacitance of the electric double layer at the surface did not depend on sulfur compounds and their concentration. The degree of inhibition by each sulfur compound on the electro–oxidation of borohydride in the presence of electrodes and its spontaneous oxidation in the absence of electrodes was similar. Thus the sulfur compound inhibitive influence on borohydride oxidation occurred without adsorbing onto the surface of the electrode. The anodic oxidation of borohydride was suppressed to less than 1/10 of the exchange current in the case of thiosulfate and sulfide. Sulfur compounds inhibited anodic oxidation of hydrazine and dimethylaminoborane as well, while the effect of each sulfur compound varied from that of borohydride.
Stark effect in Al x Ga 1-x As/GaAS coupled quantum wells (A) (1987)

Semiconductor quantum wells (QWs) have been shown to be important for application to electrooptic (EO) modulators.1 Single QWs, however, are structurally too simple for engineering electroabsorption properties, such as large modulation depth with small applied fields.