Successful Treatment of Relapse of Acute Promyelocytic Leukemia with a New Synthetic Retinoid, Am80 (1996)

Brief Reports15 May 1996Successful Treatment of Relapse of Acute Promyelocytic Leukemia with a New Synthetic Retinoid, Am80Akihiro Takeshita, MD, Yukiko Shibata, MD, Kaori Shinjo, MD, Mitsuaki Yanagi, MD, Tadasu Tobita, MD, Kazunori Ohnishi, MD, Shuichi Miyawaki, MD, Koichi Shudo, PhD, and Ryuzo Ohno, MDAkihiro Takeshita, MD, Yukiko Shibata, MD, Kaori Shinjo, MD, Mitsuaki Yanagi, MD, Tadasu Tobita, MD, Kazunori Ohnishi, MD, Shuichi Miyawaki, MD, Koichi Shudo, PhD, and Ryuzo Ohno, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-10-199605150-00006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail All-trans retinoic acid (ATRA) has proven to be a major advance in the management of patients with acute promyelocytic leukemia. Several studies [1-5] have shown that a treatment program using ATRA for induction followed by several cycles of cytotoxic chemotherapy for consolidation yields overall survival rates superior to those produced by chemotherapy alone. Nonetheless, ATRA has several important limitations, one of which is the rapid development of resistance to it by patients [6]. We report here, for the first time, that the new synthetic retinoid Am80 (4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carbamoyl] benzoic acid) (Figure 1) [7, 8] induced complete remission without serious adverse ...References1. Huang ME, Ye YC, Chen SR, Chai JR, Lu MX, Zhoa L, et al. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood. 1988; 72:567-72. Google Scholar2. Warrell RP Jr, Frankel SR, Miller WH Jr, Scheinberg DA, Itri LM, Hittelman WN, et al. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med. 1991; 324:1385-93. Google Scholar3. Ohno R, Ohnishi K, Takeshita A, Tanimoto M, Murakami H, Kanamaru A, et al. All-trans retinoic acid therapy in relapsed/refractory or newly diagnosed acute promyelocytic leukemia (APL) in Japan. Leukemia. 1994; 8(Suppl 3):S64-9. Google Scholar4. Kanamaru A, Takemoto Y, Tanimoto M, Murakami H, Asou N, Kobayashi T, et al. All-trans retinoic acid for the treatment of newly diagnosed acute promyelocytic leukemia. Japan Adult Leukemia Study Group. Blood. 1996; 85:1202-6. Google Scholar5. Warrell RP Jr, de The H, Wang ZY, Degos L. Acute promyelocytic leukemia. N Engl J Med. 1993; 329:177-89. Google Scholar6. Degos L, Dombret H, Chomienne C, Daniel MT, Miclea JM, Chastang C, et al. All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia. Blood. 1995; 85:2643-53. Google Scholar7. Kagechika H, Kawachi E, Hashimoto Y, Himi T, Shudo K. Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. J Med Chem. 1988; 31:2182-92. Google Scholar8. Hashimoto Y, Kagechica H, Kawaguchi E, Fukazawa H, Shudo K. Correlation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4. J Cancer Res Clin Oncol. 1995; 121:696-8. Google Scholar9. Yamada O, Hatake K, Tanimoto M, Ishiyama T, Ohno R, Shirakawa S, et al. [Co-operative study of all-trans retinoic acid as a differentiation induction therapy of acute promyelocytic leukemia]. Gan To Kagaku Ryoho. 1994; 21:1981-9 Google Scholar10. Cornic M, Delva L, Castaigne S, Lefebvre P, Balitrand N, Degos L, et al. In vitro all-trans retinoic acid (ATRA) sensitivity and cellular retinoic acid binding protein (CRABP) levels in relapse leukemic cells after remission induction by ATRA in acute promyelocytic leukemia. Leukemia. 1994; 8:914-7. Google Scholar11. Muindi J, Frankel SR, Miller WH Jr, Jakubowski A, Scheinberg DA, Young CW, et al. Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid resistance in patients with acute promyelocytic leukemia. Blood. 1992; 79:299-303. Google Scholar12. Miller WH Jr, Jakubowski A, Tong WP, Miller VA, Rigas JR, Benedetti F, et al. 9-cis retinoic acid induces complete remission but does not reverse clinically acquired retinoid resistance in acute promyelocytic leukemia. Blood. 1995; 85:3021-7. Google Scholar13. Zelent A, Krust A, Petkovich M, Kastner P, Chambon P. Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin. Nature. 1989; 339:714-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byImpact of CD56 Continuously Recognizable as Prognostic Value of Acute Promyelocytic Leukemia: Results of Multivariate Analyses in the Japan Adult Leukemia Study Group (JALSG)-APL204 Study and a Review of the LiteratureStrategies to generate functionally normal neutrophils to reduce infection and infection-related mortality in cancer chemotherapyTamibarotene maintenance improved relapse-free survival of acute promyelocytic leukemia: a final result of prospective, randomized, JALSG-APL204 studyEffects of AM80 compared to AC261066 in a high fat diet mouse model of liver diseaseAcute Promyelocytic LeukemiaReprogramming acute myeloid leukemia into sensitivity for retinoic-acid-driven differentiationCell-based evaluation of changes in coagulation activity induced by antineoplastic drugs for the treatment of acute myeloid leukemiaDesign, Synthesis and Evaluation of Indene Derivatives as Retinoic Acid Receptor α AgonistsTamibarotene for the treatment of acute promyelocytic leukemiaAcute Promyelocytic LeukemiaHepatic metabolism of retinoids and disease associationsPML-RARα inhibitors (ATRA, tamibaroten, arsenic troxide) for acute promyelocytic leukemiaNuclear Hormone ReceptorsTwo Patients with All-trans Retinoic Acid-Resistant Acute Promyelocytic Leukemia Treated Successfully with Gemtuzumab Ozogamicin as a Single AgentSignaling pathways in retinoid chemoprevention and treatment of cancer転写因子KLF5/BTEB2の心血管リモデリングにおける意義(1.心筋リモデリングの分子メカニズムと治療への展開)(第67回日本循環器学会学術集会)Selective retinoids and rexinoids in cancer therapy and chemopreventionRETINOID THERAPY OF CHILDHOOD CANCERRecent advances in the use of vitamin A (retinoids) in the prevention and treatment of cancerVitamin A and cancerSynthetic retinoids and their usefulness in biology and medicineEstablishment of a Myeloid Cell Line, YM711, Characterized by Retinoid ResistanceThe biologic basis for the use of retinoids in cancer prevention and treatmentRAR-Selective Ligands: Receptor Subtype and Function SelectivityRetinoids and Differentiation of Normal and Malignant Hematopoietic CellsLeukemia Cell DifferentiationThe emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancerCooperative oncology groups in Japan: Experience from the Japan Adult Leukemia Study GroupConstitutive Expression of the Promyelocytic Leukemia–Associated Oncogene PML-RARα in TF1 Cells: Isoform-Specific and Retinoic Acid–Dependent Effects on Growth, bcl-2 Expression, and ApoptosisRelapsed Acute Promyelocytic Leukemia Previously Treated with All-Trans Retinoic Acid: Clinical Experience with a New Synthetic Retinoid, Am-80Anticoagulant Effects of Synthetic Retinoids Mediated Via Different Receptors on Human Leukemia and Umbilical Vein Endothelial CellsLack of involvement of retinoic acid receptor α in retinoid-induced skin irritation in hairless miceTreatment With a New Synthetic Retinoid, Am80, of Acute Promyelocytic Leukemia Relapsed From Complete Remission Induced by All-trans Retinoic AcidCurrent approaches to acute promyelocytic leukemia 15 May 1996Volume 124, Issue 10Page: 893-896KeywordsBody surface areaBone marrowChemotherapyDrugsHemorrhageNeutrophilsPlateletsProteinsRetinoic acidRetinoids Issue Published: 15 May 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...