gebhart/patrepeval huggingface dataset:
P033 EFFICACY OF MIRIKIZUMAB ON HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH ULCERATIVE COLITIS: A RANDOMISED, DOUBLE-BLIND, CONTROLLED, PHASE 2 STUDY (2019)

The efficacy and safety of mirikizumab (miri), an IL-23p19 antibody, has been evaluated in moderate-to-severe ulcerative colitis (UC) in a phase 2, randomized, double-blind, placebo (pbo)-controlled trial (AMAC, NCT02589665; presented at DDW 2018). Miri demonstrated efficacy on multiple measures in the 12-week induction treatment. This analysis evaluated the effects of miri on health-related quality of life (HRQoL) in patients with UC. Patients with moderate-to-severe UC (Mayo score 6-12; Endoscopic subscore ≥2) were randomised 1:1:1:1 to receive intravenous miri 50 mg (N=63) or 200 mg (N=62), both with possible exposure-based increase (2-12 fold or 1.5-3 fold, respectively, to a maximum 600 mg dose), or fixed dose miri 600 mg (N=61), or pbo (N=63) at Weeks 0, 4, and 8. Patients could receive oral 5-aminosalicylic acid (ASA), corticosteroids (≤20 mg/d prednisone equivalent), or thiopurines; must have failed ≥1 conventional UC therapy; and were either naïve to or had prior exposure to biologics. HRQoL was measured by the Inflammatory Bowel Disease Questionnaire (IBDQ) and evaluated using a mixed model repeated measures (MMRM) analysis. The percentage of patients at Week 12 with clinical response,1endoscopic healing,2 IBDQ total score ≥170, and IBDQ improvement ≥16 were also assessed. As early as Week 4, and continuing through Week 12, IBDQ total scores improved versus baseline and versus pbo across all miri groups except miri 50 mg versus pbo at Week 12 (Table). At Week 12, the proportions of patients with IBDQ total score ≥170 were higher with miri 50 mg, 200 mg, and 600 mg than pbo (44%, 56%, 54% vs. 30%, respectively) and higher proportions of miri- than pbo-treated patients had improvements ≥16 points from baseline in IBDQ total score. At Week 12, clinical response and endoscopic healing rates were greater for miri 50 mg and 200 mg versus pbo (Table). Induction treatment with miri was associated with HRQoL improvement in patients with UC. These are the first data evaluating the effects of an IL-23p19 antibody on the HRQoL of patients with UC.
Synthesis of a dialkyl phosporoisocyanidate (1974)

W. J. Stec, A. Konopka and B. Uznański, J. Chem. Soc., Chem. Commun., 1974, 923b DOI: 10.1039/C3974000923B
A 40–44 Gb/s 3$\times$ Oversampling CMOS CDR/1:16 DEMUX (2007)

A CMOS CDR and 1:16 DEMUX fabricated in a low-cost 90 nm bulk CMOS process operates at 40-44 Gb/s and dissipates 910 mW. A quarter-rate hybrid phase-tracking/3times blind-oversampling architecture is used to improve jitter tolerance, reduce the need for high-power CML circuits, and enable frequency acquisition without a reference clock. Input data are sampled using a 24-phase distributed VCO, and a digital CDR recovers 16 bits and a 2.5 GHz clock from 48 demultiplexed samples spanning 16 UI. Conformance to the ITU-T G.8251 jitter tolerance mask (BER <10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> with a 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">31</sup> -1 PRBS source) is demonstrated using both an on-chip and an external BERT.
Total Synthesis of Zaragozic Acid A/Squalestatin S1 (1994)

Step by step the first total synthesis was approached: of the zaragozic acids/ squalestatins showing potential therapeutic value for lowering the serum cholesterol concentration, zaragozic acid A/squalestatin SI (1), the most abundant member of a new class of naturally occurring products, has now been synthesized via the key intermediates 2 and 3. Initially the projected final sequence (2 → 1) was achieved, and the side chains attached to C1 and C6 were prepared through efficient asymmetric syntheses. The first synthesis of the highly oxygenated “core”, which is characteristic of this class of natural products, was achieved from a simple prochiral diene via intermediate 3. Finally the synthetic route 3 → 2 was developed to successfully complete the total synthesis. Bn  benzyl, PMB  para-methoxybenzyl, TMS  trimethylsilyl.
PHOSPHORLESS COLOR TUNING OF LIGHT-EMITTING-DIODES BY RED- EMITTING NANOSTRUCTURED POROUS SILICON POWDER (2016)

In this work, powders of nanostructured porous silicon (NPSp) with strong and broad photoluminescence in the red portion of the spectrum are used as non-toxic phosphors for effectively tuning the color of commercial blue- LEDs from blue to violet, magenta, and red via wavelength conversion. NPSp/polydimethylsiloxane (PDMS) composites consisting of PDMS encapsulating different concentrations of red-emitting NPSp obtained by electro- chemical etching of silicon are prepared and spotted on top of commercial blue-LEDs. Good reliability of the tun- ing process, in terms of NPSp fabrication and concentration, and excellent stability of the tuning color, in terms of LED biasing, are demonstrated by electrical/optical characterization of several NPSp-modified commercial LEDs.
SNR-optimized image fusion for transparent object inspection (2018)

Automated visual inspection of transparent objects is important for many industrial fields. Especially the detection of scattering impurities inside complexly shaped transparent objects is a demanding task. Usually, so-called dark field approaches are employed in this case. However, these methods often fail due to direct reflections of the light sources, e.g., at the test object's surface which cannot be distinguished from signals of real material defects. This paper introduces an inspection approach which captures images at different illumination modalities and fuses them while optimizing the signal-to-noise ratio. Two fusion strategies are presented, which employ prior knowledge in order to obtain optimized inspection images. The signal component of the observed images is defined as the signal corresponding to visualized defects. Conversely, all light reaching the sensor due to scattering or reflections caused by the test object's geometry is regarded as noise. The signal values and noise values depend on both the pixel position and the respective illumination source. Prior knowledge about the signal and noise components allows to estimate the spatially resolved SNR for every illumination channel. The images resulting from the fusion step show scattering material defects with high contrast whereas surface reflections are nearly completely mitigated by the SNR-optimized fusion strategies. Several experiments state the performance of the presented approaches.
Supplementary Figure Legends from Preclinical Evidence That 3′-Deoxy-3′-[<sup>18</sup>F]Fluorothymidine PET Can Visualize Recovery of Hematopoiesis after Gemcitabine Chemotherapy (2023)

&lt;p&gt;Legends for supplementary figures.&lt;/p&gt;
Defective Craniofacial Development and Brain Function in a Mouse Model for Depletion of Intracellular Inositol Synthesis (2014)

myo-Inositol is an essential biomolecule that is synthesized by myo-inositol monophosphatase (IMPase) from inositol monophosphate species. The enzymatic activity of IMPase is inhibited by lithium, a drug used for the treatment of mood swings seen in bipolar disorder. Therefore, myo-inositol is thought to have an important role in the mechanism of bipolar disorder, although the details remain elusive. We screened an ethyl nitrosourea mutant mouse library for IMPase gene (Impa) mutations and identified an Impa1 T95K missense mutation. The mutant protein possessed undetectable enzymatic activity. Homozygotes died perinatally, and E18.5 embryos exhibited striking developmental defects, including hypoplasia of the mandible and asymmetric fusion of ribs to the sternum. Perinatal lethality and morphological defects in homozygotes were rescued by dietary myo-inositol. Rescued homozygotes raised on normal drinking water after weaning exhibited a hyper-locomotive trait and prolonged circadian periods, as reported in rodents treated with lithium. Our mice should be advantageous, compared with those generated by the conventional gene knock-out strategy, because they carry minimal genomic damage, e.g. a point mutation. In conclusion, our results reveal critical roles for intracellular myo-inositol synthesis in craniofacial development and the maintenance of proper brain function. Furthermore, this mouse model for cellular inositol depletion could be beneficial for understanding the molecular mechanisms underlying the clinical effect of lithium and myo-inositol-mediated skeletal development.
CT-X antigen expression in human breast cancer (2009)

Cancer/testis (CT) genes are predominantly expressed in human germ line cells, but not somatic tissues, and frequently become activated in different cancer types. Several CT antigens have already proved to be useful biomarkers and are promising targets for therapeutic cancer vaccines. The aim of the present study was to investigate the expression of CT antigens in breast cancer. Using previously generated massively parallel signature sequencing (MPSS) data, together with 9 publicly available gene expression datasets, the expression pattern of CT antigens located on the X chromosome (CT-X) was interrogated. Whereas a minority of unselected breast cancers was found to contain CT-X transcripts, a significantly higher expression frequency was detected in estrogen and progesterone receptor (ER) negative breast cancer cell lines and primary breast carcinomas. A coordinated pattern of CT-X antigen expression was observed, with MAGEA and NY-ESO-1/CTAG1B being the most prevalent antigens. Immunohistochemical staining confirmed the correlation of CT-X antigen expression and ER negativity in breast tumors and demonstrated a trend for their coexpression with basal cell markers. Because of the limited therapeutic options for ER-negative breast cancers, vaccines based on CT-X antigens might prove to be useful.
Elementos presentes de las organizaciones inteligentes en el desarrollo de las operaciones empresariales en las organizaciones de servicio en el distrito de Santiago, provincia de Veraguas (2023)

Los modelos de negocios requeridos para el desarrollo de las operaciones empresariales, son en muchas ocasiones modelos complejos que demandan de sus gerentes o directores un amplio conocimiento de conceptos y teorías de tipo técnicas que son imprescindibles para lograr los objetivos económicos, financieros y sociales deseados. Para tal fin es importante identificar si las empresas de servicio del distrito de Santiago, poseen elementos de organizaciones inteligentes, y las ventajas que tiene el convertirse en estas, por lo que se propuso como objetivo, determinar la presencia de los elementos de organización inteligente en el desarrollo de las operaciones empresariales de las empresas de servicio en la provincia de Veraguas; para esto, se realizó un acercamiento a la realidad con las diversas organizaciones aplicando una encuesta a 16 empresas de servicio y 100 colaboradores, entre ellas, donde se obtuvo información relevante que permite concluir que; las empresas de servicio como organizaciones tienen una estructura necesaria para poder implementar el concepto de organización inteligente, destacando que los colaboradores están en un momento ideal para lograr los objetivos propuestos.
Image sequence event detection VIA recurrence analysis (2013)

Recurrence analysis methods have been used in a wide array of fields for the purposes of obtaining some grasp of the characteristics of a chaotically dynamical system. At the heart of the recurrence plotting and quantification analysis algorithm, though, is a means of visualizing and measuring repeating sequences of time-dependent data. It is in this sense we present a novel means of extracting an event from an image sequence by analyzing selected features as multi-dimensional samples of the time-series. The analysis and development of recurrence plots (RPs) naturally lend themselves to sequence detection, and we are presenting an attempt to target eye-movement events as such time-series sequences. We can then apply relatively simple quantification measures through Recurrence Quantification Analysis (RQA), thereby immediately detecting an event and capturing some characteristic statistics. To highlight an application of this methodology, we are presenting an approach towards detecting fixational eye-movement events from a video recording of natural eye motions.
Application of Excitation from Multiple Locations on a Simplified High-Lift System (2004)

A series of active flow control experiments were recently conducted on a simplified highlift system. The purpose of the experiments was to explore the prospects of eliminating all but simply hinged leading and trailing edge flaps, while controlling separation on the supercritical airfoil using multiple periodic excitation slots. Excitation was provided by three, independently controlled, self-contained, piezoelectric actuators. Low frequency excitation was generated through amplitude modulation of the high frequency carrier wave, the actuators’ resonant frequencies. It was demonstrated, for the first time, that pulsed modulated signal from two neighboring slots interact favorably to increase lift. Phase sensitivity at the low frequency was measured, even though the excitation was synthesized from the high-frequency carrier wave. The measurements were performed at low Reynolds numbers and included mean and unsteady surface pressures, surface hot-films, wake pressures and particle image velocimetry. A modest (6%) increase in maximum lift (compared to the optimal baseline) was obtained due to the activation of two of the three actuators.
Special Issue to mark the retirement of Professor R. G. “Dick” Jones from the University of Kent at Canterbury (2009)

cited By 0
An Efficient Quasi-Three-Dimensional Model of Tilting Pad Journal Bearing for Turbomachinery Applications (2015)

The constant increase of turbomachinery rotational speed has brought the design and the use of journal bearings to their very limits: tilting pad journal bearings (TPJBs) have been introduced for high-speed/high-load applications due to their intrinsic stability properties and can be used both in transient and steady-state operations obtaining superior performances. An accurate analysis of the TPJBs behavior is essential for a successful design and operation of the system; however, it is necessary to reach a compromise between the accuracy of the results provided by the TPJB model and its computational cost. This research paper exposes the development of an innovative and efficient quasi-3D TPJB modeling approach that allows the simultaneous analysis of the system rotordynamics and the supply plant behavior; the majority of existing models describe these aspects separately but their complex interaction must be taken into account to obtain a more accurate characterization of the system. Furthermore, the proposed model is characterized by a high numerical efficiency and modularity, allowing for complex transient simulations of the complete plant and for the representation of different kind of bearings. The TPJB model has been developed and experimentally validated in collaboration with an industrial partner which provided the technical data of the system and the results of experimental tests.
Comparison of Vital Capacity Induction with Sevoflurane to Intravenous Induction with Propofol for Adult Ambulatory Anesthesia (1999)

We compared vital capacity inhaled induction (VC) with sevoflurane with IV induction with propofol for adult ambulatory anesthesia. Patients were randomly assigned to receive either 8% sevoflurane in 75% N2O/O2 from a primed circuit (VC, 32 patients) or propofol 2-mg/kg bolus (IV, 24 patients). Times to loss of consciousness (response to command) and induction side effects (airway, hemodynamic, motor) were assessed. Anesthesia was maintained with sevoflurane/N2O via a face mask for both groups. At the end of surgery, recovery times were measured and psychomotor function tests were performed. Patients were also asked to assess the quality of their anesthesia. Of the VC patients, 59% lost responsiveness in one breath, taking 39 ± 3 s. All VC patients completed the induction, and all measures of induction time were significantly shorter for VC than for IV. Induction side effects were different in the two groups (cough and hiccough for VC versus movement and blood pressure changes for IV), but overall incidences were similar. There were no significant differences in any index of early or intermediate recovery. Mild nausea occurred more often with VC, but no antiemetics were needed, and discharge was not delayed. Patients’ assessments of the quality of induction or wake up were not significantly different between VC and IV. Thus, VC induction with sevoflurane is an acceptable alternative to propofol IV induction of general anesthesia for adult ambulatory surgical patients. Implications A vital capacity induction with sevoflurane produced a faster loss of consciousness and had side effects, recovery times, and patient satisfaction similar to that of a propofol induction in adults undergoing ambulatory surgery.
Development of fluoropolymers for pellicle in 157nm lithography (2005)

Fluoropolymers have been successfully utilized for pellicle manufacturing in 248 and 193nm lithography. Moreover, the pellicle using such fluoropolymers will make a large contribution to the development of 193nm immersion technology that is now expected as NGL for 65nm and 45nm node. On the other hand, 157nm lithography is also considered to be a desirable solution as a future manufacturing technique. However, no fluoropolymers show good laser durability to 157nm irradiation. This is one of major obstacles for implementing 157nm lithography. It follows that the purpose of this research is to find out a polymer that has outstanding durability, and would therefore promote wider use of the 157nm technology. Through this research, we had synthesized some kinds of fluoropolymer platform and investigated their durability. From the investigation, we have found several criteria to control their photo-induced degradation. Based upon these criteria, we have synthesized several new fluoropolymers and investigated their durability. As the result of these evaluations, these polymers showed good initial transmission as expected. Moreover, some polymers showed good mechanical durability when exposed to over 100J/cm<sup>2</sup> irradiation. In addition, some new copolymers between monomer containing tert-hydrogen and perfluorinated monomer showed poor mechanical durability, however the polymers showed higher transparency during irradiation. To investigate these phenomena, we have analyzed these polymers using FT-IR and XPS. From these analyses, we estimate and propose possible degradation mechanism of these polymers.
Complexity in Chemistry (1999)

"Complexity" is a subject that is beginning to be important in chemistry. Historically, chemistry has emphasized the approximation of complex nonlinear processes by simpler linear ones. Complexity is becoming a profitable approach to a wide range of problems, especially the understanding of life.
Viral DNA Replication Orientation and hnRNPs Regulate Transcription of the Human Papillomavirus 18 Late Promoter (2017)

The life cycle of human papillomaviruses (HPVs) is tightly linked to keratinocyte differentiation. Although expression of viral early genes is initiated immediately upon virus infection of undifferentiated basal cells, viral DNA amplification and late gene expression occur only in the mid to upper strata of the keratinocytes undergoing terminal differentiation. In this report, we show that the relative activity of HPV18 TATA-less late promoter P<sub>811</sub> depends on its orientation relative to that of the origin (Ori) of viral DNA replication and is sensitive to the eukaryotic DNA polymerase inhibitor aphidicolin. Additionally, transfected 70-nucleotide (nt)-long single-strand DNA oligonucleotides that are homologous to the region near Ori induce late promoter activity. We also found that promoter activation in raft cultures leads to production of the late promoter-associated, sense-strand transcription initiation RNAs (tiRNAs) and splice-site small RNAs (spliRNAs). Finally, a <i>cis</i>-acting AAGTATGCA core element that functions as a repressor to the promoter was identified. This element interacts with hnRNP D0B and hnRNP A/B factors. Point mutations in the core prevented binding of hnRNPs and increased the promoter activity. Confirming this result, knocking down the expression of both hnRNPs in keratinocytes led to increased promoter activity. Taking the data together, our study revealed the mechanism of how the HPV18 late promoter is regulated by DNA replication and host factors.<b>IMPORTANCE</b> It has been known for decades that the activity of viral late promoters is associated with viral DNA replication among almost all DNA viruses. However, the mechanism of how DNA replication activates the viral late promoter and what components of the replication machinery are involved remain largely unknown. In this study, we characterized the P<sub>811</sub> promoter region of HPV18 and demonstrated that its activation depends on the orientation of DNA replication. Using single-stranded oligonucleotides targeting the replication fork on either leading or lagging strands, we showed that viral lagging-strand replication activates the promoter. We also identified a transcriptional repressor element located upstream of the promoter transcription start site which interacts with cellular proteins hnRNP D0B and hnRNP A/B and modulates the late promoter activity. This is the first report on how DNA replication activates a viral late promoter.
Cross‐Protectiveness and Immunogenicity of Influenza A/Duck/Singapore/3/97(H5) Vaccines against Infection with A/Vietnam/1203/04(H5N1) Virus in Ferrets (2006)

Ferrets were immunized with two 7- mu g doses of hemagglutinin from inactivated whole-virus vaccines containing the hemagglutinin gene of A/Duck/Singapore/3/97(H5N3) then inoculated with a lethal dose of A/Vietnam/1203/04(H5N1) (Viet/1203/04). Serum samples did not react with Viet/1203/04 in hemagglutination-inhibition (HI) or virus-neutralization (VN) tests. All vaccinated ferrets survived the challenge, whereas all mock-immunized ferrets died. Immunized ferrets had significantly lower virus titers in the upper respiratory tract and less-severe disease. Vaccine generated from antigenically different H5 virus protects against infection by a highly pathogenic H5 strain. Neither HI nor VN testing provides correlates of cross-protection in ferrets.