gebhart/patrepeval huggingface dataset:
In Vitro Rearing of the Boll Weevil (Coleoptera: Curculionidae) Ectoparasitoid Catolaccus grandis (Hymenoptera: Pteromalidae) on Meridic Diets (1996)

The pteromalid Catolaccus grandis (Burks), an obligate ectoparasitoid of the boll weevil, Anthonomus grandis grandis Boheman, successfully completed development on 5 original meridic diets. These diets produced C. grandis females of significantly higher quality than those produced on a previously reported meridic diet. Pupal weight and fecundity of females reared in the 5 meridic diets were lower than for females reared in vivo, but, higher than for females reared in a previously developed diet. There was no significant difference between progeny sex ratio of females reared in the 5 new diets from those of females reared in vivo. Based on net reproductive rate (R)0 values of females reared in the 5 new diets, the best artificial diet showed a R0 value of 135.16 as compared to an R0 value of 143.6 for parasitoids reared in vivo. Parasitoids reared in previously developed artificial diets had significantly lower pupal weight, fecundity, survival, and R0 value as compared with C. grandis reared in the 5 new diets. This implies that the presence of some amino acids such as histamine, proline, and glutamic acid in the correct proportions is essential for the growth and development of C. grandis.
Intensity distribution segmentation in Ultrafast Doppler and correlative Scanning Laser Confocal Microscopy for assessing vascular changes associated with ageing in murine hippocampi (2021)

Abstract The hippocampus plays an important role in learning and memory, requiring high-neuronal oxygenation. Understanding the relationship between blood flow and vascular structure – and how it changes with ageing – is physiologically and anatomically relevant. Ultrafast Doppler (µDoppler) and Scanning Laser Confocal Microscopy (SLCM) are powerful imaging modalities that can measure in-vivo Cerebral Blood Volume (CBV) and ex-vivo vascular structure, respectively. Here, we apply both imaging modalities to a cross-sectional and longitudinal study of hippocampi vasculature in wild-type mice brains. We introduce a segmentation of CBV distribution obtained from µDoppler and show that this mice-independent and mesoscopic measurement is correlated with the number of vessels and Vessel Volume Fraction (VVF) distributions obtained from SLCM – e.g., high CBV relates to fewer number of vessels but with large VVF. Moreover, we find significant changes in CBV distribution and vasculature due to ageing (5 vs. 21 month-old mice), highlighting the sensitivity of our approach. Overall, we are able to associate CBV with vascular structure – and track its longitudinal changes – at the artery-vein, venules, arteriole, and capillary levels. We believe that this correlative approach can be a powerful tool for studying other acute (e.g., brain injuries), progressive (e.g., neurodegeneration) or induced pathological changes.
Improving the form factor of a wrist-based mobile gesture interface (2010)

We present the form factor design iteration process of the Gesture Watch, a wearable gesture interface that utilizes non-contact hand gestures to control mobile devices while non-visual feedback is provided from its tactile display. Based on limitations discovered from a previous prototype, we identified three design challenges: wearability, mobility, and tactile perception. In addressing these challenges, we focus on three main parts affecting the form factor: the sensor housing, the strap, and the motor housing.
General discussion (1981)

J. Rooney, R. K. Grasselli, F. Trifiro, J. Haber, A. W. Sleight, J. M. Thomas, J. C. Védrine, J. C. Volta, I. Huang, G. Öhlmann, J. G. van Ommen, G. Munuera, G. C. Bond, J. C. Vickerman, W. O. Haag, J. W. Ward, D. A. Dowden, M. W. Roberts, J. Cunningham and Z. Paál, Faraday Discuss. Chem. Soc., 1981, 72, 303 DOI: 10.1039/DC9817200303
Perfect imaging analysis of the spherical geodesic waveguide (2012)

Negative Refractive Lens (NRL) has shown that an optical system can produce images with details below the classic Abbe diffraction limit. This optical system transmits the electromagnetic fields, emitted by an object plane, towards an image plane producing the same field distribution in both planes. In particular, a Dirac delta electric field in the object plane is focused without diffraction limit to the Dirac delta electric field in the image plane. Two devices with positive refraction, the Maxwell Fish Eye lens (MFE) and the Spherical Geodesic Waveguide (SGW) have been claimed to break the diffraction limit using positive refraction with a different meaning. In these cases, it has been considered the power transmission from a point source to a point receptor, which falls drastically when the receptor is displaced from the focus by a distance much smaller than the wavelength. Although these systems can detect displacements up to &lambda;/3000, they cannot be compared to the NRL, since the concept of image is different. The SGW deals only with point source and drain, while in the case of the NRL, there is an object and an image surface. Here, it is presented an analysis of the SGW with defined object and image surfaces (both are conical surfaces), similarly as in the case of the NRL. The results show that a Dirac delta electric field on the object surface produces an image below the diffraction limit on the image surface.
Detailed electromagnetic simulation for the structural color of butterfly wings (2009)

Many species of butterflies exhibit interesting optical phenomena due to structural color. The physical reason for this color is subwavelength features on the surface of a single scale. The exposed surface of a scale is covered with a ridge structure. The fully three-dimensional, periodic, finite-difference time-domain method is used to create a detailed electromagnetic model of a generic ridge. A novel method for presenting the three-dimensional observed color pattern is developed. Using these tools, the change in color that is a result of varying individual features of the scale is explored. Computational models are developed that are similar to three butterflies: Morpho rhetenor, Troides magellanus, and Ancyluris meliboeus.
A Common Pathway for Detergent-Assisted Oligomerization of Aβ42 (2023)

Abstract Amyloid beta (Aβ) aggregation is a slow process without seeding or assisted nucleation. Sodium dodecyl sulfate (SDS) micelles stabilize Aβ42 small oligomers (in the dimer-tetramer range); subsequent SDS removal leads to a 150-kD Aβ42 oligomer. Dodecylphosphorylcholine (DPC) micelles also stabilize an Aβ42 tetramer. Here we characterize the detergent-assisted oligomerization pathway by solid-state NMR spectroscopy and molecular dynamics simulations. SDS and DPC-induced oligomers have the same structure, implying a common oligomerization pathway. An antiparallel β-sheet formed by the C-terminal region, the only stable structure in SDS and DPC micelles, is directly incorporated into the 150-kD oligomer. Three Gly residues (at positions 33, 37, and 38) create holes that are filled by the SDS and DPC hydrocarbon tails, thereby turning a potentially destabilizing feature into a stabilizing factor. These observations have implications for endogenous Aβ aggregation at cellular interfaces.
A kinase associated with chromatin that can be activated by ligand-p185c-Neu or epidermal growth factor-receptor interactions. (1995)

Some growth factors transduce positive growth signals, while others can act as growth inhibitors. Nuclear signaling events of previously quiescent cells stimulated with various growth factors have been studied by isolating the complexed chromatin-associated proteins and chromatin-associated proteins. Signals from the plasma membrane are integrated within the cells and quickly transduced to the nucleus. It is clear that several growth factors, such as epidermal growth factor, transforming growth factor alpha (but not transforming growth factor beta), and platelet-derived growth factor, utilize similar intracellular signaling biochemistries to modulate nucleosomal characteristics. The very rapid and consistent phosphorylation of nuclear p33, p54, and low molecular mass proteins in the range of 15-18 kDa after growth factor stimulation implies that there is a coordination and integration of the cellular signaling processes. Additionally, phosphorylation of p33 and some low molecular mass histones has been found to occur within 5 min of growth factor treatment and to reach a maximum by 30 min. In this study, we report that Neu receptor activating factor also utilizes the same signaling mechanism and causes p33 to become phosphorylated. In addition, both the tumor promoter okadaic acid (which inhibits protein phosphatases 1 and 2A) and phorbol ester (phorbol 12-tetradecanoate 13-acetate) stimulate phosphorylation of p33, p54, and low molecular mass histones. However, transforming growth factor beta, which is a growth inhibitor for fibroblasts, fails to increase p33 phosphorylation. In general, p33 phosphorylation patterns correspond to positive and negative mitogenic signal transduction. p33 isolated from the complexed chromatin-associated protein fraction appears to be a kinase, or tightly associated with a kinase, and shares antigenicity with the cell division cycle-dependent Cdk2 kinase as determined by antibody-dependent analysis. The rapid phosphorylation of nucleosomal proteins may influence sets of early genes needed for the induction and progression of the cell cycle.
Pericyclic Reactions of Organic Molecules at Semiconductor Surfaces (2012)

This chapter contains sections titled: Introduction [2+2] Cycloaddition of Alkenes and Alkynes [4+2] Cycloaddition of Dienes Cycloaddition of Unsaturated Organic Molecules Containing One or More Heteroatom Summary Acknowledgment References
Systemic immunization induces protective CD4+ and CD8+ T cell‐mediated immune responses in murine Listeria monocytogenes meningoencephalitis (1995)

The immune mechanisms underlying immunization-induced protection of mice from lethal central nervous system (CNS) listeriosis were evaluated by immunohistochemistry, flow cytometry of leukocytes isolated from the brain, reverse transcription-polymerase chain reaction analysis of intracerebral (i.c.) tumor-necrosis factor-alpha, interferon-gamma, interleukin (IL)-2, IL-1 beta, IL-10, granulocyte/macrophage colony-stimulating factor, and inducible nitric oxide synthase mRNA expression, and T cell depletion experiments. The data demonstrate that active immunization of mice prior to an i.c. infection with Listeria monocytogenes prevents the development of a fatal necrotizing encephalitis and accelerates the recruitment of an increased number of alpha beta T cell receptor (TcR)+ CD4+ and CD8+ T cells, gamma delta TcR+ T cells, B cells, granulocytes and macrophages to the brain compared to non-immunized animals. In addition, immunization induced a pronounced activation of i.c. macrophages and microglial cells as shown by an increased expression of MHC class II antigens. In parallel, transcript levels for all cytokine mRNA analyzed were higher in the brains of immunized mice. The protective effects of immunization were completely abolished by depletion of CD4+, CD8+, or both T cell subsets. All groups of T cell-depleted immunized mice developed a fatal necrotizing encephalitis with an increased i.c. bacterial load. In addition, cytokine mRNA synthesis was significantly impaired. The severity of disease was only slightly different between CD4+, CD8+ and CD4+/CD8+ T cell depleted mice, indicating that both subsets of T cells are required for an effective i.c. immune response to L. monocytogenes. This is in marked contrast to systemic listeriosis, and points to CNS-specific features of the immune response.
Surface-modified three-dimensional graphene nanosheets as a stationary phase for chromatographic separation of chiral drugs (2018)

Carbon-based stationary phases for chromatographic separation have been commercially available since the 1980s. Porous graphitic carbon liquid chromatography columns are known to be highly resistant to aggressive mobile phases and extreme pH values of solvents and eluents, an important advantage compared to conventional silica-based alternatives. In our work, we demonstrate a new variant of carbon-based stationary phases for liquid chromatography, specifically developed for chiral separation. Mesoporous three-dimensional graphene nanosheets (3D GNS), functionalized with tetracyanoethylene oxide (TCNEO) and (S)-(+)-2-pyrrolidinemethanol, demonstrate pharmaceutical-grade chiral separation of model ibuprofen and thalidomide racemic mixtures when used as Chiral Stationary Phases (CSPs), with performance parameters comparable to currently commercially available CSPs. Simple covalent attachment of functionalization groups to the surface of mesoporous three-dimensional graphene nanosheets makes these carbon-based CSPs chemically stable and up to an order of magnitude less expensive than standard silica-based analogues.
Dynamik und Mobilität: 50 Jahre Forschung in der Metallorganischen Chemie (1999)

Abstract 50 Jahre Metallorganische Chemie wurden zum Siegeszug einer Disziplin, die es kurz vorher als solche nicht gab. Wer was geleistet hat in 50 Jahren, das ist schon jetzt Geschichte — junge Geschichte allerdings und deshalb einzeln noch nicht bewertbar, so Ernst Otto Fischer und Wolfgang A. Herrmann, die Autoren des folgenden Beitrags.
Global motion processing: Invariance with mean luminance (2010)

We examine how global translational motion sensitivity varies with the mean luminance of the stimulus. Using DC-balanced, spatially narrowband micropatterns (radial Log Gabors) matched in terms of detectability (multiples above contrast threshold), we show that global translational motion sensitivity is invariant with the mean luminance. Contrast detection thresholds, however, show a characteristic spatial frequency dependence on mean luminance. Similar results were found for central and peripheral regions of the field and for a range of different micropattern velocities (2.1 deg/s to 84 deg/s). Thus, the sensitivity of global motion processing that occurs in extrastriate cortical areas, unlike the detectability of the stimuli themselves that occurs in lower visual areas, does not vary with mean luminance.
Nasal Immunization of Mice with Human Papillomavirus Type 16 Virus-Like Particles Elicits Neutralizing Antibodies in Mucosal Secretions (1998)

To specifically induce a mucosal antibody response to purified human papillomavirus type 16 (HPV16) virus-like particles (VLP), we immunized female BALB/c mice orally, intranasally, and/or parenterally and evaluated cholera toxin (CT) as a mucosal adjuvant. Anti-HPV16 VLP immunoglobulin G (IgG) and IgA titers in serum, saliva, and genital secretions were measured by enzyme-linked immunosorbent assay (ELISA). Systemic immunizations alone induced HPV16 VLP-specific IgG in serum and, to a lesser extent, in genital secretions but no secretory IgA. Oral immunization, even in the presence of CT, was inefficient. However, three nasal immunizations with 5 microgram of VLP given at weekly intervals to anesthetized mice induced high (>10(4)) and long-lasting (>15 weeks) titers of anti-HPV16 VLP antibodies in all samples, including IgA and IgG in saliva and genital secretions. CT enhanced the VLP-specific antibody response 10-fold in serum and to a lesser extent in saliva and genital secretions. Nasal immunization of conscious mice compared to anesthetized mice was inefficient and correlated with the absence of uptake of a marker into the lung. However, a 1-microgram VLP systemic priming followed by two 5-microgram VLP intranasal boosts in conscious mice induced both HPV16 VLP-specific IgG and IgA in secretions, although the titers were lower than in anesthetized mice given three intranasal immunizations. Antibodies in serum, saliva, and genital secretions of immunized mice were strongly neutralizing in vitro (50% neutralization with ELISA titers of 65 to 125). The mucosal and systemic/mucosal HPV16 VLP immunization protocols that induced significant titers of neutralizing IgG and secretory IgA in mucosal secretions in mice may be relevant to genital HPV VLP-based human vaccine trials.
Attempts to Assemble a Universal NMR Database without Synthesis of NMR Database Compounds (2006)

[structure: see text] The feasibility of assembling 3JH,H profiles from NMR data collected on relevant, but not necessarily specific, NMR database compounds representing a given stereocluster was demonstrated. By this approach, the 3JH,H profile was created for the contiguous tetraol peracetate stereocluster. The reliability and applicability of the database thus assembled were demonstrated for known peracetates derived from two heptoses.
Digital redesign of continuous time controller by multirate sampling and high order holds (2003)

This paper presents the digital redesign of continuous time controller when the measurement sampling period is relatively large and standard discretization methods are most likely not able to provide a suitable digital controller from either stability or performance point of view. An analysis tool is provided to improve the performance of digital control systems by the following two measures: 1) update the controller output N times faster than the measurement sampling frequency; and 2) utilize past sampled outputs to predict the evolution of the output error between two consecutive sampling instances. The analysis tool is developed by regarding the overall system as a multirate sampled data system. An illustrative example is given to show the utilization of the developed analysis tool.
The cortical deficit in humans with strabismic amblyopia (2001)

To further our understanding of the cortical deficit in strabismic amblyopia, we measured, compared and mapped functional magnetic resonance imaging (fMRI) activation between the fixing and fellow amblyopic eyes of ten strabismic amblyopes. Of specific concern was whether the function of any visual area was spared in strabismic amblyopia, as recently suggested by both positron emission tomography (PET) and fMRI studies, and whether there was a close relationship between the fMRI response and known psychophysical deficits. To answer these questions we measured the psychophysical deficit in each subject and used stimuli whose relationship to the psychophysical deficit was known. We observed that stimuli that were well within the amblyopic passband did produce reduced fMRI activation, even in visual area V1. This suggests that V1 is anomalous in amblyopia. A similar level of reduction was observed in V2. In two subjects, we found that stimuli outside the amblyopic passband produced activation in visual area V3A. We did not find a close relationship between the fMRI response reduction in amblyopia and either of the known psychophysical deficits even though the fMRI response reduction in amblyopia did covary with stimulus spatial frequency.
Contribution on notch antenna loaded by magneto-dielectric material (2011)

International audience
A New Sensor System for Accurate 3D Surface Measurements and Modeling of Underwater Objects (2022)

A new underwater 3D scanning device based on structured illumination and designed for continuous capture of object data in motion for deep sea inspection applications is introduced. The sensor permanently captures 3D data of the inspected surface and generates a 3D surface model in real time. Sensor velocities up to 0.7 m/s are directly compensated while capturing camera images for the 3D reconstruction pipeline. The accuracy results of static measurements of special specimens in a water basin with clear water show the high accuracy potential of the scanner in the sub-millimeter range. Measurement examples with a moving sensor show the significance of the proposed motion compensation and the ability to generate a 3D model by merging individual scans. Future application tests in offshore environments will show the practical potential of the sensor for the desired inspection tasks.
Sophomore-Level Curriculum Innovation in Electrical and Computer Engineering (2020)

where he is currently leading a group of graduate students on a variety of research projects in the areas of RF MEMS, sensing and power harvesting applications as well as RFID sensors for the health monitoring of sensitive equipment. He has been a PI or a co-PI in numerous projects
A novel 3D microdevice for the in vivo capture of cancer‐associated cells (2019)

Abstract Circulating tumour cells (CTCs) correlate by their number to the lethal potential of the tumour and can be characterized in terms of molecular properties. The repeated isolation of living CTCs has now appeared as an unavoidable step towards their use as biomarkers in clinical routine. We introduce a 3D stealthy microdevice adapted to the in vivo capture of CTCs in the venous blood flow, on the basis of their physical characteristics, size and rigidity. Embedded in a fluidic bench mimicking an artificial arm vein, it readily captured human prostate cancer cells spiked into donor blood down to a concentration of 1,000 cells/ml. The isolation of cancer cells in venous circulation was validated in an animal model in vivo. These results open new avenues to the characterization of CTCs in prognosis, personalization of treatments and follow‐up, not only as a research tool, but also for repeated monitoring in clinical practice.
Quantitative EEG Parameters for Prediction of Outcome in Severe Traumatic Brain Injury: Development Study (2017)

Monitoring of quantitative EEG (QEEG) parameters in the intensive care unit (ICU) can aid in the treatment of traumatic brain injury (TBI) patients by complementing visual EEG review done by an expert. We performed an explorative study investigating the prognostic value of 59 QEEG parameters in predicting the outcome of patients with severe TBI. Continuous EEG recordings were done on 28 patients with severe TBI in the ICU of Turku University Hospital. We computed a set of QEEG parameters for each patient, and correlated these to patient outcome, measured by dichotomized Glasgow Outcome Scale (GOS) at a follow-up visit between 6 and 12 months, using area under receiver operating characteristic curve (AUC) as a nonlinear correlation measure. For 17 of the 59 QEEG parameters (28.8%), the AUC differed significantly from 0.5, most of these parameters measured EEG power or variability. The best QEEG parameters for outcome prediction were alpha power (AUC = 0.87, P < .01) and variability of the relative fast theta power (AUC = 0.84, P < .01). The results of this study indicate that QEEG parameters provide useful information for predicting outcome in severe TBI. Novel QEEG parameters with potential in outcome prediction were found, the prognostic value of these parameters should be confirmed in later studies. The results also provide further evidence of the usefulness of parameters studied in preexisting studies.