gebhart/patrepeval huggingface dataset:
Visual Query Language: Finding patterns in and relationships among time series data (2004)

Many scientific datasets archive a large number of variables over time. These timeseries data streams typically track many variables over relatively long periods of time, and therefore are often both wide and deep. In this paper, we describe the Visual Query Language (VQL) [3], a technology for locating time series patterns in historical or real time data. The user interactively specifies a search pattern, VQL finds similar shapes, and returns a ranked list of matches. VQL supports both univariate and multivariate queries, and allows the user to interactively specify the the quality of the match, including temporal warping, amplitude warping, and temporal constraints between features.
Gain-switched multicarrier transmitter in a long-reach UDWDM PON with a digital coherent receiver (2013)

The authors report on the downlink performance of a 10 Gb/s long-reach and ultra-dense wavelength-division multiplexed passive optical network, based on a multicarrier transmitter realized by using an externally injected gain-switched distributed-feedback laser diode. Each of the comb channels, spaced by 10 GHz, is modulated with a 3 Gbaud dual polarization quadrature phase shift keying signal that included a 20% overhead for forward error correction. Frequency selectivity and enhanced receiver sensitivity is achieved by employing a digital coherent receiver to receive the signal. Experimental results achieved in a back-to-back and 100 km transmission scenarios show an excellent worst case receiver sensitivity of -44 dBm.
A Review of the Systems Approach to the Analysis of Dynamic-Mode Atomic Force Microscopy (2007)

The atomic force microscope (AFM) is one of the foremost tools for imaging, measuring and manipulating matter at the nanoscale. This brief presents a review of the systems and control approach to analyzing the challenging dynamic-mode operation of the AFM. A Lure system perspective of the AFM dynamics facilitates the application of powerful tools from systems theory for the analysis. The harmonic balance method provides significant insights into the steady-state behavior as well as a framework for identifying the tip-sample interaction force. A simple piecewise-linear tip-sample interaction model and its identification using the harmonic balance method is presented. The dominant first harmonic is analyzed using multivalued frequency responses and the corresponding stability conditions. The ability of the simple tip-sample interaction model to capture the intricate nonlinear behavior of the first harmonic is demonstrated. This also points to the importance of studying the higher harmonics to obtain finer details of the tip-sample interaction. The suitability of the Lure system perspective for the analysis of the higher harmonics is demonstrated.
Reduction of risk of development of Alzheimer’s disease and related dementias in patients with type 2 diabetes by drugs to treat hyperglycemia (2021)

Abstract Background Alzheimer’s Disease and Related Dementias (ADRD) are progressive neurodegenerative disorders that manifest in reduced cognition, executive function and memory impairments. Type 2 Diabetes (T2D) is suggested to be a risk factor for the development of ADRD. In this study, we evaluated the effects of anti‐hyperglycemic medications (HM) to treat hyperglycemia in T2D patients on the incidence of newly diagnosed ADRD. Method Using a retrospective analysis of healthcare claims dataset (Mariner 30), patients receiving HM for T2D treatment were identified and survival analysis, stratified by individual therapeutics, was used to determine the association between HM exposure and diagnosis of ADRD. A propensity score approach was used to minimize measured and unmeasured selection bias. Result In this cohort study of propensity score matched T2D patients over the age of 45, HM exposure was associated with decrease in diagnosis of ADRD, most specifically AD (RR, 0.61; 95% CI, 0.59‐0.62; P &lt;0.001), Vascular Dementia (RR, 0.72; 95% CI, 0.69‐0.74; P &lt; 0.001) and Dementia (RR, 0.65; 95% CI, 0.64‐0.66; P &lt; 0.001). Patients that did not use HM were more likely to develop an ADRD. The protection by the use of HM was more pronounced after propensity score matching comorbidities significantly correlated with the assignment to HM treatment. Metformin was the most protective and insulin was the least protective compared to patients not taking any HM. The differences between these therapies was not due to age, gender or Charleston Comorbidity Index. Conclusion After controlling for age, gender and comorbidities, the use of HM in patients with T2D protected against the development of ADRD.
Impact of a posttraumatic cerebral infarction on outcome in patients with TBI: the Italian multicenter cohort INCEPT study (2020)

Abstract Background Post-traumatic cerebral infarction (PTCI) is common after traumatic brain injury (TBI). It is unclear what the occurrence of a PTCI is, how it impacts the long-term outcome, and whether it adds incremental prognostic value to established outcome predictors. Methods This was a prospective multicenter cohort study of moderate and severe TBI patients. The primary objective was to evaluate if PTCI was an independent risk factor for the 6-month outcome assessed with the Glasgow Outcome Scale (GOS). We also assessed the PTCI occurrence and if it adds incremental value to the International Mission for Prognosis and Clinical Trial design in TBI (IMPACT) core and extended models. Results We enrolled 143 patients, of whom 47 (32.9%) developed a PTCI. In the multiple ordered logistic regression, PTCI was retained in both the core and extended IMPACT models as an independent predictor of the GOS. The predictive performances increased significantly when PTCI was added to the IMPACT core model (AUC = 0.73, 95% C.I. 0.66–0.82; increased to AUC = 0.79, 95% CI 0.71–0.83, p = 0.0007) and extended model (AUC = 0.74, 95% C.I. 0.65–0.81 increased to AUC = 0.80, 95% C.I. 0.69–0.85; p = 0.00008). Patients with PTCI showed higher ICU mortality and 6-month mortality, whereas hospital mortality did not differ between the two groups. Conclusions PTCI is a common complication in patients suffering from a moderate or severe TBI and is an independent risk factor for long-term disability. The addition of PTCI to the IMPACT core and extended predictive models significantly increased their performance in predicting the GOS. Trial registration The present study was registered in ClinicalTrial.gov with the ID number NCT02430324 .
On the origin of the spontaneous formation of nanocavities in hexagonal bronzes (W,V)O3 (2014)

Hexagonal (W,V)O3-x oxides of high thermal stability have been synthesized hydrothermally through the intermediate products Nax(W,V)O3·zH2O and (NH4)0.33-x(W,V)O3-y. The obtained crystals show nanostructured surface via the formation of a dense population of polyhedral nanocavities self-distributed along particular crystallographic directions. Nanocavities present a regular size that ranges from 5 to 10 nm in both length and width. The synthesis process involves a significant topotactic relationship between the as-synthesized product and the desired final product and this relationship is suggested as the origin of the observed surface nanostructure. The comparison of our results with observations in different solids has allowed us to suggest that the formation of nanocavities is an extensive spontaneous process when materials are obtained by the chemical reactions of solids leading to products with defined crystallographic orientation with respect to the original compound. The characterization provides evidence regarding the potential relevance of nanocavities in the functional properties of the resulting solids.
A Novel Hypothalamic Peptide, Pituitary Adenylate Cyclase Activating Peptide, Modulates Sertoli Cell Function in Vitro (1992)

Pituitary adenylate cyclase-activating peptide (PACAP), a novel hypothalamic peptide that has been shown to exist in several tissues including the testis, was examined for its effects on cultured rat Sertoli cells. PACAP stimulates cAMP accumulation in Sertoli cells cultured from 15-day-old rats in the presence or absence of methylisobutylxanthine, a phosphodiesterase inhibitor, and in the presence of pertussis toxin, a blocker of the adenylate cyclase inhibitory pathway. Maximal stimulation, which is 20-40% of that attainable with FSH, occurs at PACAP concentrations of 10 nM: the ED50 is approximately 100 pM. The ability of PACAP to stimulate Sertoli cell cAMP declines with increasing age of donor animals (15-60 days of age) in a fashion similar to the FSH effect. PACAP stimulation of Sertoli cell cAMP accumulation is additive with submaximal, but not maximal, concentrations of FSH or forskolin. PACAP also stimulates the secretion of lactate, estradiol, and inhibin in a concentration-dependent manner. The stimulation of Sertoli cell cAMP accumulation by PACAP is not altered by a vasoactive intestinal peptide antagonist, and vasoactive intestinal peptide alone does not stimulate cAMP accumulation, indicating that PACAP is not acting via vasoactive intestinal peptide receptors. Further experiments are needed to determine whether PACAP is synthesized within the testis and if so, in which cell types; however, the present data clearly demonstrate that PACAP can modulate Sertoli cell function in vitro.
On-chip thin-film microtransformer with improved coupling factor for high frequency data transmission (2021)

An on-chip thin-film microtransformer with an improved coupling factor is shown in this paper. In addition to the development of this component, the characterization of the microtransformer and its use in the data transmission application are presented. In comparison to previous work, this microtransformer device shows an improved coupling factor. The microtransformer is fabricated on silicon substrate using thin-film technology. The fabrication is based on damascene process and combines material deposition using only sputtering PVD (physical vapor deposition) or CVD a (chemical vapor deposition) processes and chemical-mechanical polishing (CMP) process for patterning. The microtransformer design is a solenoid type device with a magnetic bar core and interleaved winding style. For a magnetic core a CoFeB material is applied. As insulation materials, silicon dioxide and silicon nitride are implemented. The device chip size is 1.6 mm x 0.8 mm. A turns ratio of the microtransformer is 1:1, and the device shows a self-inductance of about 25 nH and an improved coupling factor with a value of 60%.
Direct position determination using mimo radar (2008)

MIMO radar is a new concept that has recently been proposed as an extension to the multi-static radar concept. In the following paper we apply the concept of direct position determination (DPD) to MIMO radar in order to explore the effect of the transmit diversity on the target position determination accuracy. It is shown that under low signal to noise ratio (SNR) conditions the results of the MIMO radar DPD improve the estimation accuracy by more than an order of magnitude with respect to conventional, geolocation method.
Quantitative Determination of Ion Migration in a Thin-Layer Electrochemical FT-IR Cell (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative Determination of Ion Migration in a Thin-Layer Electrochemical FT-IR CellMahesh G. Samant, Keiji. Kunimatsu, and Hajime. SekiCite this: Anal. Chem. 1994, 66, 10, 1781–1783Publication Date (Print):May 15, 1994Publication History Published online1 May 2002Published inissue 15 May 1994https://pubs.acs.org/doi/10.1021/ac00082a030https://doi.org/10.1021/ac00082a030research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Low-voltage circuit design for widespread sensing applications (2008)

Ubiquitous computing has a number of compelling applications ranging from biomedical sensing to environmental monitoring. These computing systems require low cost sensor nodes with volumes ≪1mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> and lifetimes on the order of months or years. We advocate the use of aggressively scaled supply voltages in such applications to maximize energy efficiency. This paper reviews our recent progress in mapping out the low energy design space. We explore the design and test of three low voltage systems targeting ubiquitous computing. We conclude with a survey of open research directions in the ultra-low energy design space.
Energy-efficient high-speed packet access in WCDMA systems with smart packet dispatching: performance with TCP/IP based applications (2003)

This paper presents a performance analysis of high-speed downlink packet access (HSDPA) for TCP/IP applications in WCDMA systems with smart packet dispatching (SPD). The focus is on energy efficiency over burst-error correlated fading channels. The fading-channel characterization thereof is due to low user mobility of the primarily targeted environments for HSDPA applications. Using theoretical analysis and simulation, we show that in burst-error correlated fading channels adapting the time instant of scheduling/dispatching retransmission to fading-channel conditions: (i) significantly reduces the number of retransmissions; and (ii) helps closing the gap of bad channel states allowing the system to operate with much lower fade margin or transmit-power. It thus improves the efficiency of resource utilization in HSDPA. This method is referred to as SPD. In our modeling, we study the impact of fading based on fade duration statistics. The effects of diversity, mobility, and QoS constraints (such as timer for discarding out-of-date packets) are taken into account. The results are used to develop simple and energy-efficient adaptive SPD mechanisms.
Association of Pretransplant Renal Function With Liver Graft and Patient Survival After Liver Transplantation in Patients With Nonalcoholic Steatohepatitis (2018)

Nonalcoholic steatohepatitis (NASH) is one of the top 3 indications for liver transplantation (LT) in Western countries. It is unknown whether renal dysfunction at the time of LT has any effect on post-LT outcomes in recipients with NASH. From the United Network for Organ Sharing-Standard Transplant Analysis and Research data set, we identified 4088 NASH recipients who received deceased donor LT. We divided our recipients a priori into 3 categories: group 1 with estimated glomerular filtration rate (eGFR) <30 mL/minute/1.73 m<sup>2</sup> at the time of LT and/or received dialysis within 2 weeks preceding LT (n = 937); group 2 with recipients who had eGFR ≥30 mL/minute/1.73 m<sup>2</sup> and who did not receive renal replacement therapy prior to LT (n = 2812); and group 3 with recipients who underwent simultaneous liver-kidney transplantation (n = 339). We examined the association of pretransplant renal dysfunction with death with a functioning graft, all-cause mortality, and graft loss using competing risk regression and Cox proportional hazards models. The mean ± standard deviation age of the cohort at baseline was 58 ± 8 years, 55% were male, 80% were Caucasian, and average exception Model for End-Stage Liver Disease score was 24 ± 9. The median follow-up period was 5 years (median, 1816 days; interquartile range, 1090-2723 days). Compared with group 1 recipients, group 2 recipients had 19% reduced trend for risk for death with a functioning graft (subhazard ratio [SHR], 0.81; 95% confidence interval [CI], 0.64-1.02) and similar risk for graft loss (SHR, 1.25; 95% CI, 0.59-2.62), whereas group 3 recipients had similar risk for death with a functioning graft (SHR, 1.23; 95% CI, 0.96-1.57) and graft loss (SHR, 0.18; 95% CI, 0.02-1.37) using an adjusted competing risk regression model. In conclusion, recipients with preserved renal function before LT showed a trend toward lower risk of death with a functioning graft compared with SLKT recipients and those with pretransplant severe renal dysfunction in patients with NASH.
How have new sterilization techniques and new forms of polyethylene influenced wear in total joint replacement? (2008)

Polyethylene has undergone many changes over the past several decades, including changes in consolidation processes, resin types, sterilization methods, packaging, and the extent of cross-linking. We believe that new sterilization techniques and forms of polyethylene have generally improved wear performance. Polyethylene sterilized without the use of radiation has been shown to have relatively high rates of wear in vivo. Ram-extruded polyethylene sterilized via gamma irradiation in air has been the most commonly used bearing material in the past several decades. Recently, components molded and gamma-sterilized without oxygen as well as highly cross-linked material have found increased clinical use. Exposure of polyethylene to radiation, either to sterilize it or to intentionally cross-link it, has been shown to improve the wear performance of the material. Newer second-generation methods of cross-linking polyethylene include the use of vitamin E, which quenches free radicals and demonstrates promise in providing low wear and desirable mechanical properties.
Decoding trajectories of imagined hand movement using electrocorticograms for brain–machine interface (2022)

<i>Objective</i>. Reaching hand movement is an important motor skill actively examined in the brain-computer interface (BCI). Among the various components of movement analyzed is the hand's trajectory, which describes the hand's continuous positions in three-dimensional space. While a large body of studies have investigated the decoding of real movements and the reconstruction of real hand movement trajectories from neural signals, fewer studies have attempted to decode the trajectory of the imagined hand movement. To develop BCI systems for patients with hand motor dysfunctions, the systems essentially have to achieve movement-free control of external devices, which is only possible through successful decoding of purely imagined hand movement.<i>Approach</i>. To achieve this goal, this study used a machine learning technique (i.e. the variational Bayesian least square) to analyze the electrocorticogram (ECoG) of 18 epilepsy patients obtained from when they performed movement execution (ME) and kinesthetic movement imagination (KMI) of the reach-and-grasp hand action.<i>Main results</i>. The variational Bayesian decoding model was able to successfully predict the imagined trajectories of the hand movement significantly above the chance level. The Pearson's correlation coefficient between the imagined and predicted trajectories was 0.3393 and 0.4936 for the KMI (KMI trials only) and MEKMI paradigm (alternating trials of ME and KMI), respectively.<i>Significance</i>. This study demonstrated a high accuracy of prediction for the trajectories of imagined hand movement, and more importantly, a higher decoding accuracy of the imagined trajectories in the MEKMI paradigm compared to the KMI paradigm solely.
Tailor-Made Engineering of Bioinspired Inks for Writing Barcode-like Multifunctional Sensory Electronics (2019)

This letter reports on a novel cost-efficient and multifunctional barcode-like sensors array (BLSA) printed with a conductive bioinspired smart ink. The conductive ink (P@G ink), which can be further chemically engineered with different organic ligands, was generated via facile one-pot hydrothermal reduction of graphene oxide (GO) in dopamine (DA) as coreductan Usingvarious chemical derivatives of the P@G inks on a flexible substrate (e.g., Kapton), a highly integrated BLSA as well as smart nose/tongue mimic array were generated for simultaneous sensing and distinguishing of complex physical and chemical stimuli, including temperature, light, air pressure, relative humidity, and volatile organic compounds (VOCs). Due to these very attractive features, the reported P@G ink-based BLSA would have the potential for unique opportunities regarding "all-in-one"-yet cost-effective-disposable electronics and sensors.
Grasp control using compliance control with variable stiffness matrix (2004)

In this paper we present a grasping control system based on position control. The sliding mode control, which excels in robustness, is used as the position controller. Because the position control performs the grasping, it is not necessary to change the control rule accompanying the approach/grasp phase. The control system is, therefore, stable. Grasped objects may slip from fingertips when the mass of the objects and the posture of the robot's hands change. To avoid this problem, the friction coefficient is identified in real time. We believe that objects begin to slip when the friction coefficient value exceeds the maximum coefficient of friction. Using this coefficient as a threshold value, the grasping force is increased by increasing joint compliance. Our proposed control system was applied to a multifingered hand, and its efficacy and usefulness was verified.