gebhart/patrepeval huggingface dataset:
Aging Fly Cell Atlas Identifies Exhaustive Aging Features at Cellular Resolution (2022)

Abstract Aging is characterized by a decline in tissue function, but the underlying changes at cellular resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a single-nucleus transcriptomic map of the whole aging Drosophila . We characterize 163 distinct cell types and perform an in-depth analysis of changes in tissue cell composition, gene expression, and cell identities. We further develop aging clock models to predict the fly age and show that ribosomal gene expression is a conserved predictive factor for age. Combining all aging features, we find unique cell type-specific aging patterns. This atlas provides a valuable resource for studying fundamental principles of aging in complex organisms.
Temperature dependence of three-dimensional domain wall arrangement in ferroelectric K0.9Na0.1NbO3 epitaxial thin films (2020)

The three-dimensional arrangement and orientation of domain walls in ferroelectric K0.9Na0.1NbO3/(110)NdScO3 epitaxial thin films were investigated at different temperatures both experimentally by means of piezoresponse force microscopy and three-dimensional x-ray diffraction and theoretically by three-dimensional phase-field simulations. At room temperature, a well-ordered herringbone-like domain pattern appears in which there is a periodic arrangement of a1a2/MC monoclinic phases. Four different types of domain walls are observed, which can be characterized by out-of-plane tilt angles of ±45° and in-plane twist angles of ±21°. For the orthorhombic high-temperature phase, a periodic a1/a2 stripe domain pattern with exclusive in-plane polarization is formed. Here, two different types of domain walls are observed, both of them having a fixed out-of-plane domain wall angle of 90° but distinguished by different in-plane twist angles of ±45°. The experimental results are fully consistent with three-dimensional phase-field simulations using anisotropic misfit strains. The qualitative agreement between the experiment and the theory applies, in particular, to the wide phase transition range between about 180 °C and 260 °C. In this temperature range, a complex interplay of coexisting monoclinic a1a2/MC and orthorhombic a1/a2 phases takes place.
Theoretical considerations for selective harmonic control (2006)

Recent work in selective harmonic control expanded the solution space compared to the conventional problem formulations. This paper explores the nature of the expanded solution space. It is shown under various constraints the number of solutions can be one, infinity, or bounded by a large finite number. The work further examines sensitivity of solutions to errors in the placement of switching edges that arise due to physical constraints. It is shown that this sensitivity is quite manageable with common digital hardware.
Kinetic studies of the oxidation of horse heart ferrocytochrome c, Pseudomonas aeruginosa ferrocytochrome c551, Co(terpy)22+, and Ru(NH3)5py2+ by tris(1,10-phenanthroline)cobalt(III) ions (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetic studies of the oxidation of horse heart ferrocytochrome c, Pseudomonas aeruginosa ferrocytochrome c551, Co(terpy)22+, and Ru(NH3)5py2+ by tris(1,10-phenanthroline)cobalt(III) ionsJames V. McArdle, Kathryn Yocom, and Harry B. GrayCite this: J. Am. Chem. Soc. 1977, 99, 12, 4141–4145Publication Date (Print):June 1, 1977Publication History Published online1 May 2002Published inissue 1 June 1977https://pubs.acs.org/doi/10.1021/ja00454a038https://doi.org/10.1021/ja00454a038research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Design and synthesis of cobalt(III) nitrogen mustard complexes as hypoxia selective cytotoxins. The X-ray crystal structure of bis(3-chloropentane-2,4-dionato)(RS-N,N′-bis(2-chloroethyl)ethylenediamine)cobalt(III) perchlorate, [Co(Clacac)2(bce)]ClO4 (1991)

The design, synthesis and biological evaluation of [Co(Meacac)2(dce)]+, a cobalt(III) nitrogen mustard complex that is effective as a hypoxia selective cytotoxin for potential anti-cancer use, is reported.
MLPACK: A Scalable C++ Machine Learning Library (2012)

MLPACK is a state-of-the-art, scalable, multi-platform C++ machine learning library released in late 2011 offering both a simple, consistent API accessible to novice users and high performance and flexibility to expert users by leveraging modern features of C++. MLPACK provides cutting-edge algorithms whose benchmarks exhibit far better performance than other leading machine learning libraries. MLPACK version 1.0.3, licensed under the LGPL, is available at http://www.mlpack.org.
The Combinatorial Approach to Asymmetric Hydrogenation: More Miles Out of Monophos (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Psychosocial Adjustment in Long Term Survivors of Allogeneic HSCT: A Comparison of Patients Treated with Myeloablative (MC) and Reduced Intensity Conditioning (RIC) Regimens (2009)

Background: Long term survivors of allogeneic HSCT (aHSCT) may experience significant psychosocial distress. Although factors predicting increased distress have been reported, the influence of conditioning intensity has not been explored. Purpose: This analysis compares the psychosocial (PS) adjustment of long term survivors who received RIC (n = 43) or MC (n = 77) regimens and examines predictors of PS adjustment and its relationship with health-related quality of life (HRQL). Methods: Cross-sectional data were drawn from an ongoing longitudinal study. Measures included the Psychosocial Adjustment to Illness Scale (PAIS), the Rotterdam Symptom Checklist-physical (RSCL-P) and the Functional Assessment of Cancer Therapy – General (FACT-G). Data were analyzed using descriptive statistics, correlation and regression analyses. Results: Subjects (N = 120) were a median of 62 months from aHSCT (range 34–156), predominantly male (59%), married (63%), and had an ECOG status of 0 (86%). Mean scores for PS adjustment did not differ between the RIC (27.6±2.56) and MC (26.1±1.82) groups (t = 4.93, p = 0.62). Age, gender, marital status, education, employment, transplant conditioning intensity, performance status and physical symptom distress explained 50.5% of the variability in PAIS scores (F = 9.30, p<0.01). Being unmarried (β =−0.169, p = 0.044) and experiencing greater physical symptom distress (β = 0.609, p<0.001) independently predicted poor adjustment. Poor PS adjustment was strongly associated with poor HRQL (r =−0.78, p<0.001). Survivors (n = 29; 24%) with poor adjustment (PAIS T-score ≥62) reported the greatest difficulties with family (immediate and extended) issues, sexual relationships and psychological distress. Conclusion: Understanding the factors that predict poor PS adjustment in survivors of aHSCT guides assessment strategies including approaches to systematically assess and manage distressing symptoms. Studies to develop and test educational and counseling interventions that optimize individual and family functioning, including sexual relationships, in transplant recipients are warranted. Acknowledgment: This research was supported by the Intramural Research Program of the NIH.
Synthesis and Characterization of Metal Modified Catalysts for Decomposition of Ibuprofen from Aqueous Solutions (2020)

The presence of pharmaceuticals in surface water, drinking water, and wastewater has attracted significant concern because of the non-biodegradability, resistance, and toxicity of pharmaceutical compounds. The catalytic ozonation of an anti-inflammatory pharmaceutical, ibuprofen was investigated in this work. The reaction mixture was analyzed and measured by high-performance liquid chromatography (HPLC). Liquid chromatography-mass spectrometry (LC-MS) was used for the quantification of by-products during the catalytic ozonation process. Ibuprofen was degraded by ozonation under optimized conditions within 1 h. However, some intermediate oxidation products were detected during the ibuprofen ozonation process that were more resistant than the parent compound. To optimize the process, nine heterogeneous catalysts were synthesized using different preparation methods and used with ozone to degrade the ibuprofen dissolved in aqueous solution. The aim of using several catalysts was to reveal the effect of various catalyst preparation methods on the degradation of ibuprofen as well as the formation and elimination of by-products. Furthermore, the goal was to reveal the influence of various support structures and different metals such as Pd-, Fe-, Ni-, metal particle size, and metal dispersion in ozone degradation. Most of the catalysts improved the elimination kinetics of the by-products. Among these catalysts, Cu-H-Beta-150-DP synthesized by the deposition–precipitation process showed the highest decomposition rate. The regenerated Cu-H-Beta-150-DP catalyst preserved the catalytic activity to that of the fresh catalyst. The catalyst characterization methods applied in this work included nitrogen adsorption–desorption, scanning electron microscopy, transmission electron microscopy, and Fourier-transform infrared spectroscopy. The large pore volume and small metal particle size contributed to the improved catalytic activity.
SUMO1 Modification of Tau in Progressive Supranuclear Palsy (2022)

Small ubiquitin-like modifiers (SUMO) have been implicated in several neurodegenerative diseases. SUMO1 conjugation has been shown to promote aggregation and regulate phosphorylation of the tau protein linked to Alzheimer&apos;s disease and related tauopathies. The current study has demonstrated that SUMO1 colocalizes with intraneuronal tau inclusions in progressive supranuclear palsy (PSP). To examine the effects of SUMOylation on the tau based pathology of PSP, several tau-SUMO fusion proteins were prepared. As the results, truncated tau especially showed a higher propensity for tau oligomerization and accumulation on microtubules as compared to the full-length protein. In addition, tau-SUMO1 fusion protein
Centralized data recording for a distributed surgical skills trainer to facilitate automated proficiency evaluation. (2007)

Virtual reality simulators have the capability to automatically record user performance data in an unbiased, cost effective manner that is also less error prone than manual methods. Centralized data recording simplifies proficiency evaluation even more; however is not commonly available to date for surgical skills trainers. We will detail our approach in implementing a framework for distributed score recording over the Internet using a database for persistent storage.
Joint Regression Modeling and Sparse Spatial Refinement for High-Quality Reconstruction of Distorted Color Images (2019)

High quality algorithms are demanded to reconstruct distorted color images in a variety of applications. For example, distortions can result during transmission over lossy channels in image coding or in multi-view imaging scenarios. In general, not all color channels are equally affected and the losses distribute differently in-between channels. However, state-ofthe-art methods process color channels independently and do not take the cross color information into account. Thus, a novel and powerful reconstruction algorithm is formulated in this contribution that exploits color as well as spatial information. Therefore, an initial model is estimated for the distorted area using a reference channel. Then, its quality is estimated and a spatial weighting model is set-up. Afterwards, the initial inter channel prediction is refined by generating a sparse model that takes the spatial correlations into account, as well. Consequently, the proposed method achieves an outstanding quality compared to state-of-the-art methods.
Development of DNA vaccines as an anti-hypertensive therapy or for anti-angiogenesis (2015)

To date, several clinical studies of DNA vaccines have been conducted, but their effectiveness has not been determined. We hope that the novel concept of DNA vaccines will contribute to promoting health and medicine in the future.
Gender-Inclusiveness Personas vs. Stereotyping (2017)

Personas often aim to improve product designers' ability to "see through the eyes of" target users through the empathy personas can inspire - but personas are also known to promote stereotyping. This tension can be particularly problematic when personas (who, of course as "people" have genders) are used to promote gender inclusiveness - because reinforcing stereotypical perceptions can run counter to gender inclusiveness. In this paper we explicitly investigate this tension through a new approach to personas: one that includes multiple photos (of males and females) for a single persona. We compared this approach to an identical persona with only one photo using a controlled laboratory study and an eye-tracking study. Our goal was to answer the following question: is it possible for personas to encourage product designers to engage with personas while at the same avoiding promoting gender stereotyping? Our results are encouraging about the use of personas with multiple pictures as a way to expand participants' consideration of multiple genders without reducing their engagement with the persona.
Early stages of fatigue crack initiation in the cast and wrought polycrystalline nickel-base superalloy AD730TM (2022)

International audience
Texture and Microstructure of the Austenite in Multiphased Steel Sheets (2004)

In this paper we present results obtained in collaboration between NSC and Arcelor on the austenite of a multiphased steel and on a 70%Ni-30Fe alloy. The work concerns the formation of the crystallographic textures during the recrystallisation of austenite, since these textures have a strong influence, after the phase transformation, on the forming properties of the sheets. The microstructure and the textures of the austenite and the FeNi alloy were measured with X-Ray diffraction techniques and with EBSD on a high resolution FEG-SEM.
Comparison of Mucosal Markers of Human Immunodeficiency Virus Susceptibility in Healthy Premenopausal Versus Postmenopausal Women (2017)

The objective of this study was to characterize cervicovaginal (CV) mucosal factors modulating susceptibility to human immunodeficiency virus (HIV) acquisition in healthy premenopausal (PRE) and postmenopausal (POST) women before and after treatment with estradiol (E2). We compared CV mucosal epithelial histology and immune cells, vaginal microbiota, antimicrobial activity of and soluble mucosal protein concentrations in the CV fluid lavage (CVL), and p24 antigen production after ex vivo infection of ectocervical tissues with HIV-1<sub>BaL</sub> among PRE women (n = 20) in the follicular and luteal phases of the menstrual cycle and POST women (n = 17) at baseline and after ∼1 month of treatment with 0.01% vaginal E2 cream. Compared to PRE women, we measured higher levels of p24 antigen after ex vivo infection in tissues from POST women. POST women had a significantly thinner vaginal epithelium with decreased tight junction proteins and a higher density of mucosal immune T cells and lower levels of CD1a antigen-presenting cells, antimicrobial peptides, and inflammatory cytokines in the CVL (p values <.05). POST women had higher vaginal pH and lower vaginal Lactobacilli (p values <.05) than PRE women. After vaginal E2 therapy, CV endpoints and ex vivo HIV replication in POST tissues were similar to those observed in PRE tissues. The CV mucosa in POST women is thinned and compromised, with increased HIV-target immune cells and decreased antimicrobial factors, being more susceptible to HIV infection. After POST women receive topical E2 treatment, mucosal endpoints are similar to PRE levels.
Statistical V<inf>TH</inf> shift variation self-convergence scheme using near threshold V<inf>WL</inf> injection for local electron injected asymmetric pass gate transistor SRAM (2011)

A 6T-SRAM macro with the V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> shift variation self-convergence scheme of the asymmetric pass gate transistor by the local electron injection is proposed. The statistical V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> shift variation of the pass gate (PG) transistor is measured and the positive correlation between the PG transistor V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> shift and its original V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> due to V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> effect is self-compensated by the negative correlation between those by I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> effect. As a result, the measured PG transistor V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> shift is less correlated with the V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> of PG before injection. In order to enhance I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> effect and reduce V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> effect for a self-convergence in V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> shift, near threshold V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">WL</sub> self-convergence injection scheme is proposed. The proposed scheme reduces V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> effect by 38% and enhances I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</sub> effect by 20%. Furthermore, the fabricated SRAM macro demonstrates 3 times larger word-line operation voltage window, 41% less read margin variation and 80mV lower V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CCMIN</sub> after the local electron injection.
Human Granulocyte-Macrophage Colony-Stimulating Factor (hGM-CSF) Induces Inhibition of Intrathymic T-Cell Development in hGM-CSF Receptor Transgenic Mice (1997)

Thymocytes show differential cytokine responses, depending on the stage of differentiation. Whether these responses are due to preferential cytokine receptor expression or due to downstream signaling mechanisms is unknown. In this study, we examined the relationship between receptor expression and T-cell proliferation or differentiation using thymocytes from transgenic mice constitutively expressing the human granulocyte-macrophage colony-stimulating factor (hGM-CSF) receptor. Transgenic CD4- CD8-, CD4+ CD8-, and CD4- CD8+ cells proliferated when cultured with hGM-CSF in vitro, whereas CD4+ CD8+ cells failed to proliferate. To examine the effect of hGM-CSF receptor signaling on T-cell development, we used fetal thymic organ cultures. The addition of exogenous hGM-CSF resulted in the failure of CD4- CD8- cells to differentiate into CD4+ CD8+ cells. To more closely identify this maturational inhibition, we reconstituted normal fetal lobes with sorted pro-T-, pre-T-, or post-pre-T-precursor cells from transgenic mice. The addition of hGM-CSF to these cultures led to a block in both pro-T- and pre-T-cell differentiation, whereas the more mature post-pre-T cells differentiated normally. We propose that hGM-CSF receptor signaling during T-cell development results in a stage-specific inhibition of thymic precursor maturation.
Metabolic Engineering of Lignan Biosynthesis in Forsythia Cell Culture (2009)

Lignans are a large class of secondary metabolites in plants, with numerous biological effects in mammals, including antitumor and antioxidant activities. Sesamin, the most abundant furofuran-class lignan in sesame seeds (Sesamum plants), is produced by the cytochrome P450 enzyme CYP81Q1 from the precursor lignan, pinoresinol. In contrast, Forsythia plants produce dibenzylbutyrolactone-class lignans, such as matairesinol, from pinoresinol via the catalysis of pinoresinol/lariciresinol reductase (PLR) and secoisolariciresinol dehydrogenase. Here we present the engineering of lignan biosynthesis in Forsythia cell suspension cultures for the development of an efficient production method of beneficial lignans. A suspension cell culture prepared from leaves of Forsythia koreana produced lignans, mainly pinoresinol and matairesinol glucosides, at levels comparable with that obtained from the leaves. In an attempt to increase the pinoresinol content in Forsythia, we generated a transgenic cell line overexpressing an RNA interference (RNAi) construct of PLR (PLR-RNAi). Down-regulation of PLR expression led to a complete loss of matairesinol and an accumulation of approximately 20-fold pinoresinol in its glucoside form in comparison with the non-transformant. Moreover, the Forsythia transgenic cells co-expressing CYP81Q1 and PLR-RNAi exhibited production of sesamin as well as accumulation of pinoresinol glucoside. These data suggest Forsythia cell suspension to be a promising tool for the engineering of lignan production. To the best of our knowledge, this is the first report on transgenic production of an exogenous lignan in a plant species.
Investigation of electrical programmable metal fuse in 28nm and beyond CMOS technology (2011)

Minimum blowing current and thermal reliability of metal fuse were studied on various lengths of top and bottom metal line. By optimizing the length of top metal line, the programming current window can be extended. Next to optimize the length of bottom metal line, enough metal void size formed by thermally assisted electro-migration can be obtained in the bottom metal line and the metal void is far away from via bottom enabling highly stable operation. We think metal fuse technology is indispensable for the 28nm technology node and beyond with the introduction of metal gate/high-k process.