gebhart/patrepeval huggingface dataset:
Absorptivity enhancement of black silicon using electroless Cu plating (2020)

In this work, lightly-doped black silicon (BSi) is fabricated using cryogenic DRIE in a maskless manner and its transmittance and reflectance are measured using an integrating sphere and a spectrometer in the near infrared (NIR) wavelength range of 1300 nm - 2500 nm. Then, the surface is cleaned and copper (Cu) is deposited on the BSi using the wet deposition technique of electroless plating, enabling high throughput coating. The copper ions are deposited on the BSi surface in a Cu sulphate solution, taking advantage of the conformity of the plating to the nano/micro structures of the BSi targeting lower reflectance and higher absorptivity. The Cu-plated BSi is measured and observed to have a minimum reflectance of 10% compared to 30% in the case of BSi, and a minimum transmittance of 10% compared to 40% in the bare black silicon. Thus, the Cu-plated BSi has a maximum absorptivity of about 80% compared to 30% in the bare BSi. The absorptivity is found to decrease with increasing the wavelength. This enhancement using the electroless Cu plating further qualifies the BSi as a candidate for NIR thermal light sources.
Reconfigurable Antenna-Based Space-Shift Keying (SSK) for MIMO Rician Channels (2015)

In this work, we use the concept of the new emerging technology of reconfigurable antennas (RAs) in an effort to improve the performance of space shift keying (SSK). Indeed, the reconfigurable properties of RAs can be used as additional degrees of freedom to enhance the performance of SSK in terms of throughput, system complexity, and error performance. In this context, considering correlated and nonidentically distributed Rician fading channels, we propose a number of SSK-RA schemes using SSK with antenna-state selection while taking advantage of the effect of RAs on the multipath propagation channel. More specifically, based on the variation of the Rician K-factor and the correlation coefficients with different antenna states, the proposed schemes jointly optimize the fading and correlation parameters to enhance SSK's performance. In this paper, we analyze the performance of the proposed SSK-RA schemes over Rician fading channels in terms of average spectral efficiency (ASE) and bit error rate (BER). We also provide several simulation examples through which we corroborate these analytical results. The proposed schemes are shown to enhance the performance of SSK both in terms of ASE and BER. For the same ASE, compared to that of SSK, not only do the proposed SSK-RA schemes provide much better error performance, they also reduce the implementation cost and the overall system complexity considerably.
The DiPPro Approach: Synthesis, Hydrolysis, and Antiviral Activity of Lipophilic d4T Diphosphate Prodrugs (2014)

Bioreversible protection of the β-phosphate group of nucleoside diphosphates (NDPs) as bis(acyloxybenzyl)phosphate esters is presented. To investigate the structure-activity relationship of these potential NDP prodrugs (DiPPro drugs) a series of DiPPro compounds was synthesized bearing fatty acids of various lengths and d4T as a model nucleoside. For synthesis of the lipophilically modified diphosphate group, preformed phosphoramidites were allowed to react with nucleotides, and the β-P(III) moiety was subsequently oxidized. The chemical and enzymatic stability of these prodrugs was studied in different media such as phosphate buffer (pH 7.3) or CEM cell extracts. In all media, the hydrolysis rate was clearly dependent on the acyl moiety and decreased with increasing alkyl chain length. The compounds showed a markedly lower half-life in cell extracts than in pH 7.3 phosphate buffer due to the presence of enzyme-catalyzed cleavage. In all media, the DiPPro compounds released d4T diphosphate (d4TDP) as the main product beside d4TMP. In antiviral assays, the compounds proved to be at least as potent as d4T against HIV-1 and 2 in wild-type CEM/0 cells. As a proof of concept, compounds with longer acyl residues showed very good anti-HIV activities in thymidine-kinase-deficient cells (CEM/TK(-) ), indicating their ability to penetrate cell membranes and the delivery of phosphorylated metabolites.
ERRATUM: “Versailles project on advanced materials and standards interlaboratory study on intensity calibration for x-ray photoelectron spectroscopy instruments using low-density polyethylene” [J. Vac. Sci. Technol. A 38, 063208 (2020)] (2021)

This is a correction to: Versailles Project on Advanced Materials and Standards interlaboratory study on intensity calibration for x-ray photoelectron spectroscopy instruments using low-density polyethylene cf . HAL hal-03105700v1
Two Cases of Supernumerary Nipple (2010)

Purpose: Supernumerary nipple or polythelia is one of the developmental anomalies occurring at the embryonic stage and this anomaly usually arises from the milk line. While this atypical feature is determined during early developmental stage, it may not come out obviously or become troublesome until puberty or lactation. Moreover, sometimes it is confused with a pigmented nevus. Methods: Case 1, a 18-year-old woman with intramammary supernumerary breast consisted of another nipple with middle sized areola on the right lower breast was admitted for a -sized mass on the right breast which was starting appeared 1 year earlier. The preliminary cytological examination of the material obtained by needle aspiration biopsy from the mass was revealed by fibroadenoma with no malignant change. The patient had the surgical excision of the mass and accessory breast. Case 2, a 16 year-old woman admitted for intra-areolar polythelia of the left breast, even she doesn't have any family history of polythelia. Since she wanted surgical correction of her atypical nipple for aesthetic and psychological reasons, we reconstructed the areola using transposition flaps in an S-plasty design. Results: Case 1, the excised supernumerary nipple showed following histological features. In the superficial layer, an acanthotic and hyperpigmented epithelium with elongated rete ridges was found. In the dermis, there were follicles with hairs surrounded by hypertrophic sebaceous glands. In the deepest portion, abundant secretory glomerules and excretory ducts of apocrine gland type were observed. Case 2, follow-up visits 3 months after the procedure showed a satisfactory result with good shape and projection of the nipple. Conclusion: We report two cases of aberrant mammary tissue who underwent surgical correction, including complete breast (with nipple, areola, and glandular tissue) and intra-areolar polythelia according to the Kajava's classification, and the results were satisfactory.
Performance Analysis of Simultaneous Multithreading in a PowerPC-based Processor (2002)

Simultaneous multithreading (SMT) is an approach to address the well-known problems of memory accesses increasingly dominating processor execution time and of limited instruction level parallelism. Previous research has explored the benefits and limitations of SMT based on specific processor architectures under a variety of workloads. In this paper, we present a performance analysis of SMT in a PowerPC-based wide superscalar processor architecture under a broad range of workloads, which includes combinations of TPC-C, SPECint and SPECfp. Although some of our results are consistent with previous work, our results also demonstrate some differences and we use these results to explore and identify the primary causes of such differences. This includes an investigation of thread characteristics that work well together in SMT environments, and thread characteristics that do not work well together.
ChemInform Abstract: Synthesis of Some 3,6‐Disubstituted Pyridazines. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An Adaptable Network Control and Reporting System (ANCORS) (2003)

We present ANCORS, an Adaptable Network Control and Reporting System that merges technology from network management and distributed simulation to provide a unified paradigm for assessing, controlling, and designing active networks. ANCORS introduces a framework to assist in managing the substantial complexities of software reuse and scalability in active network environments. Specifically, ANCORS provides an extensible approach to the dynamic integration, management, and runtime assessment of various network protocols in live network operations. We present some of the advantages that can be obtained by merging technology from network management, distributed simulation, and active networking, and describe how ANCORS leverages complementary elements of each. We also introduce an ANCORS facility called the active network daemon Anetd, which supports the deployment and system management of a large class of legacy software and newer active network applications under the ANCORS framework. Lastly, we present a prototype network engineering service that was developed to demonstrate ANCORS's capabilities.
Normal lymphocyte homeostasis and function in MALT1 protease‐resistant HOIL‐1 knock‐in mice (2022)

The uniqueness of MALT1 protease activity in controlling several aspects of immunity in humans has made it a very attractive therapeutic target for multiple autoimmune diseases and lymphoid malignancies. Despite several encouraging preclinical studies with MALT1 inhibitors, severe reduction in regulatory T cells and immune-mediated pathology seen in MALT1 protease-dead (MALT1-PD) mice and some, but not all, studies analysing the effect of prolonged pharmacological MALT1 protease inhibition, indicates the need to further unravel the mechanism of MALT1 protease function. Notably, the contribution of individual MALT1 substrates to the immune defects seen in MALT1-PD mice is still unclear. Previous in vitro studies indicated a role for MALT1-mediated cleavage of the E3 ubiquitin ligase HOIL-1 in the modulation of nuclear factor-κB (NF-κB) signalling and inflammatory gene expression in lymphocytes. Here, we addressed the immunological consequences of inhibition of HOIL-1 cleavage by generating and immunophenotyping MALT1 cleavage-resistant HOIL-1 knock-in (KI) mice. HOIL-1 KI mice appear healthy and have no overt phenotype. NF-κB activation in T or B cells, as well as IL-2 production and in vitro T-cell proliferation, is comparable between control and HOIL-1 KI cells. Inhibition of HOIL-1 cleavage in mice has no effect on thymic T-cell development and conventional T-cell homeostasis. Likewise, B-cell development and humoral immune responses are not affected. Together, these data exclude an important role of MALT1-mediated HOIL-1 cleavage in T- and B-cell development and function in mice.
Dysphagia research in the 21st century and beyond: proceedings from Dysphagia Experts Meeting, August 21, 2001. (2007)

Swallowing problems (dysphagia) can occur at any age but are most prevalent in elderly individuals and are a growing healthcare concern as the geriatric population expands. Without effective diagnosis and treatment, dysphagia may lead to serious medical conditions such as pneumonia, dehydration, and malnutrition. Experts in the field of dysphagia met on August 21, 2001, in Rockville, Maryland, to respond to this heightened healthcare need and to determine the course of dysphagia research. Presentations at the meeting included epidemiological data, geriatric-specific issues, diagnostic techniques, risk factors for pneumonia, and recent relevant trials. The experts identified outstanding issues in dysphagia research, such as study design, population selection, and the standardization of diagnostic and treatment protocols. They designed a clinical trial that represents what they deem is one of the greatest needs in dysphagia research, providing a critical springboard for research endeavors with far-reaching implications.
Homopolymer (2017)

IUPAC recommendations on source-based nomenclature for single-strand polymers have so far addressed its application mainly to copolymers, non-linear polymers and polymer assemblies, and within generic source-based nomenclature of polymers. In this document, rules are formulated for devising a satisfactory source-based name for a polymer, whether homopolymer or copolymer, which are as clear and rigorous as possible. Thus, the source-based system for naming polymers is presented in a totality that serves as a user-friendly alternative to the structure-based system of polymer nomenclature. In addition, because of their widespread and established use, recommendations for the use of traditional names of polymers are also elaborated.
Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency (2016)

Intestinal dysbiosis is thought to confer susceptibility to inflammatory bowel disease (IBD), but it is unknown whether dynamic changes in the microbiome contribute to fluctuations in disease activity. We explored this question using mice with intestine-specific deletion of C1galt1 (also known as T-synthase) (Tsyn mice). These mice develop spontaneous microbiota-dependent colitis with a remitting/relapsing course due to loss of mucin core-1 derived O-glycans. 16S rRNA sequencing and untargeted metabolomics demonstrated age-specific perturbations in the intestinal microbiome and metabolome of Tsyn mice compare with littermate controls at weeks 3 (disease onset), 5 (during remission), and 9 (after relapse). Colitis remission corresponded to increased levels of FoxP3+RORγt+CD4+ T cells in the colonic lamina propria that were positively correlated with operational taxonomic units (OTUs) in the S24-7 family and negatively correlated with OTUs in the Clostridiales order. Relapse was characterized by marked expansion of FoxP3-RORγt+CD4+ T cells expressing IFNγ and IL17A, which were associated with Clostridiales OTUs distinct from those negatively correlated with FoxP3+RORγt+CD4+ T cells. Our findings suggest that colitis remission and relapse in the Tsyn model may reflect alterations in the microbiome due to reduced core-1 O-glycosylation that shift the balance of regulatory and pro-inflammatory T cell subsets. We investigated whether genetic variation in C1galt1 correlated with the microbiome in a cohort of 78 Crohn's disease patients and 101 healthy controls. Polymorphisms near C1galt1 (rs10486157) and its molecular chaperone, Cosmc (rs4825729), were associated with altered composition of the colonic mucosal microbiota, supporting the relevance of core-1 O-glycosylation to host regulation of the microbiome.
Supplementary Figure Legends from High <i>FGFR1–4</i> mRNA Expression Levels Correlate with Response to Selective FGFR Inhibitors in Breast Cancer (2023)

&lt;p&gt;Supplementary Figure Legends&lt;/p&gt;
MIXING PHENOMENA OF FUEL SPRAYS IN INTAKE MANIFOLDS (2023)

For the future design of environmentally-friendly spare ignition engines (Si-engines) more detailed knowledge of the fundamental physical phenomena in the temporal course of mixture formation processes is essential. One possible way to obtain the required information is the visualization of the two-phase flow within a real intake manifold of a Si-engine under working conditions coupled with a fundamental flow analysis and numerical modelling. In the present paper two visualization methods are applied:<br> First, a fiber optic probe is employed inside an intake manifold of a 1.8-litre-engine with a multi-point injection system. Then, for a more detailed analysis, a transparent intake manifold of an identical geometry is used. Combined with a cycle-resolved laser light-sheet technique the crank-angle dependent behavior of the spray and liquid film inside the intake manifold is visualized. Based on the observations, conclusions can be drawn, which effects in the intake manifold are of dominant importance determining the mixture preparation process and which may be negligible.
The Influence of Fuel Cetane Number on Catalyst Light-Off Operation in a Modern Diesel Engine (2017)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The design of modern diesel-powered vehicles involves optimization and balancing of trade-offs for fuel efficiency, emissions, and noise. To meet increasingly stringent emission regulations, diesel powertrains employ aftertreatment devices to control nitrogen oxides, hydrocarbons, carbon monoxide, and particulate matter emissions and use active exhaust warm-up strategies to ensure those devices are active as quickly as possible. A typical strategy for exhaust warm-up is to operate with retarded combustion phasing, limited by combustion stability and HC emissions. The amount of exhaust enthalpy available for catalyst light-off is limited by the extent to which combustion phasing can be retarded.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;Diesel cetane number (CN), a measure of fuel ignition quality, has an influence on combustion stability at retarded combustion phasing. Diesel fuel in the United States tends to have a lower CN (both minimum required and average in market) than other countries. It is unclear from existing literature to what extent low CN influences the ability to retard combustion phasing while limiting engine-out hydrocarbon emissions during the catalyst light-off phase.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;To begin to address this question, a single-cylinder engine study was conducted to compare the ability to generate exhaust temperature and enthalpy with low emissions with fuels of 46 and 53 CN. The fuels were found to produce comparable exhaust temperature, enthalpy and emissions when the engine was operated at the same calibration. However, when the calibrations were optimized separately for each fuel to maximize exhaust temperature and enthalpy while controlling emissions at or below a target level, the higher CN fuel tolerated significantly greater post injection retard within the hydrocarbon and particulate matter emissions constraints, thus enabling increased exhaust enthalpy and temperature.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;This study suggests that while a change in market CN would have only a slight impact on catalyst light-off and tailpipe emissions in legacy vehicles, future vehicles may be limited by low cetane fuel in their ability to achieve ultra-low emissions such as those required for California LEV III and Federal Tier 3. The study also highlights the importance of the assessment methodology when making conclusions about the effect of fuels on legacy and future vehicles.&lt;/div&gt;&lt;/div&gt;
<title>Are image quality metrics adequate to evaluate the quality of geometric objects?</title> (2001)

Geometric objects are often represented by many millions of triangles or polygons, which limits the ease with which they can be transmitted and displayed electronically. This has lead to the development of many algorithms for simplifying geometric models, and to the recognition that metrics are required to evaluate their success. The goal is to create computer graphic renderings of the object that do not appear to be degraded to a human observer. The perceptual evaluation of simplified objects is a new topic. One approach has been to sue image-based metrics to predict the perceived degradation of simplified 3D models. Since that 2D images of 3D objects can have significantly different perceived quality, depending on the direction of the illumination, 2D measures of image quality may not adequately capture the perceived quality of 3D objects. To address this question, we conducted experiments in which we explicitly compared the perceived quality of animated 3D objects and their corresponding 2D still image projections. Our results suggest that 2D judgements do not provide a good predictor of 3D image quality, and identify a need to develop 'object quality metrics.'
Data from Sangivamycin-like Molecule 6 Exhibits Potent Anti-Multiple Myeloma Activity through Inhibition of Cyclin-Dependent Kinase-9 (2023)

&lt;div&gt;Abstract&lt;p&gt;Despite significant treatment advances over the past decade, multiple myeloma (MM) remains largely incurable. In this study we found that MM cells were remarkably sensitive to the death-inducing effects of a new class of sangivamycin-like molecules (SLM). A panel of structurally related SLMs selectively induced apoptosis in MM cells but not other tumor or nonmalignant cell lines at submicromolar concentrations. SLM6 was the most active compound &lt;i&gt;in vivo&lt;/i&gt;, where it was well tolerated and significantly inhibited growth and induced apoptosis of MM tumors. We determined that the anti-MM activity of SLM6 was mediated by direct inhibition of cyclin-dependent kinase 9 (CDK9), which resulted in transcriptional repression of oncogenes that are known to drive MM progression (&lt;i&gt;MAF, CCND1, MYC&lt;/i&gt;, and others). Furthermore, SLM6 showed superior &lt;i&gt;in vivo&lt;/i&gt; anti-MM activity more than the CDK inhibitor flavopiridol, which is currently in clinical trials for MM. These findings show that SLM6 is a novel CDK9 inhibitor with promising preclinical activity as an anti-MM agent. &lt;i&gt;Mol Cancer Ther; 11(11); 2321–30. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Hydrogen anion and subgap states in amorphous In–Ga–Zn–O thin films for TFT applications (2017)

Hydrogen is an impurity species having an important role in the physical properties of semiconductors. Despite numerous studies, the role of hydrogen in oxide semiconductors remains an unsolved puzzle. This situation arises from insufficient information about the chemical state of the impurity hydrogen. Here, we report direct evidence for anionic hydrogens bonding to metal cations in amorphous In–Ga–Zn–O (a-IGZO) thin films for thin-film transistors (TFT) applications and discuss how the hydrogen impurities affect the electronic structure of a-IGZO. Infrared absorption spectra of self-standing a-IGZO thin films prepared by sputtering reveal the presence of hydrogen anions as a main hydrogen species (concentration is ∼1020 cm−3) along with the hydrogens in the form of the hydroxyl groups (∼1020 cm−3). Density functional theory calculations show that bonds between these hydride ions with metal centers give rise to subgap states above the top of the valence band, implying a crucial role of anionic hydrogen in the negative bias illumination stress instability commonly observed in a-IGZO TFTs.