gebhart/patrepeval huggingface dataset:
Neutrophil gelatinase-associated lipocalin as a biomarker of cardiovascular disease: a systematic review (2012)

There is ample literature to support a putative role of NGAL in the pathophysiology of CVD, but at present there is insufficient data regarding the clinical utility of systemic NGAL levels in the management of CVD. Available evidence regarding NGAL as a predictor of outcomes in CVD is very limited.
First real-time coherent MIMO-DSP for six coupled mode transmission (2015)

We present the first real-time transmission experiment over a 60-km-long fiber supporting six coupled spatial and polarization modes, enabled by a custom receiver board and an FPGA-implementation of an unconstrained adaptive frequency-domain MIMO equalizer.
Generation of Sub-5 fs Light Pulses (1997)

High energy 20-fs pulses were spectrally broadened to more than 250 nm by self-phase modulation in a hollow fiber filled with noble gases and subsequently compressed in a broadband high-throughput dispersive system. Pulses as short as 4.5 fs with 20-μJ energy were obtained with krypton.
Effects of Organizational Trust (2006)

This study examined the relationship between levels of organizational trust (OT) and nursing turnover rates, turnover expenditures, patient satisfaction scores, nurse managers' job satisfaction, and nurse managers' perception of fair compensation. An OT inventory and demographic questionnaire were used to collect data from 57 nurse managers working for not-for-profit hospitals in California. Pearson correlations analysis showed that OT was statistically significantly (p = .05) related to overall hospital patient satisfaction scores, nurse managers' job satisfaction, nurse managers' perception of fair compensation, and executives' tenure. OT was not correlated with nursing turnover rates or nursing turnover expenditures. By focusing on developing an environment of OT, hospital executives may increase job satisfaction and perceptions of fair compensation among nurse managers, possible resulting in increased patient satisfaction scores.
Solid-state lasers emitting at red, green and orange wavelengths for projection applications (2011)

Lasers will bring a further step in terms of compactness and efficiency for projection systems. However, the availability of suitable green laser sources limits the advent of laser projection. Blue diode pumped solid-state lasers are presented here as one promising way to realize green, red and orange lasers that are specifically suitedfor projection applications.
All-optical pump-seed synchronization for few-cycle OPCPA (2005)

We suggest and experimentally verify a simple method for timing-jitter-free synchronization of the seed and pump pulses in an optical parametric chirped-pulse amplifier. A fraction of a broadband seed pulse centered at 800 nm was frequency-shifted in a photonic crystal fiber to enable synchronized seeding of a picosecond Nd:YAG pump laser.
Supplementary Figures S1 - S11 from CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions (2023)

&lt;p&gt;Supplementary Figure S1. Comparison of drop out phenotypes in MKN45, RKO, HT1080 highlighting selected pan-lethal genes. Supplementary Figure S2. The genes that scored as lethal by both RNAi and CRISPR were strongly enriched for known essential genes classes. Supplementary Figure S3. To identify likely off-target hits the lethality scores of non-expressed genes were examined, as they are expected not to be required for cell viability. Supplementary Figure S4. shRNAs directed towards CDK9 do not show robust protein depletion. Supplementary Figure S5. Additional methods measuring the proliferation effects of individual sgRNA/shRNAs to validate the impact that targeting selected genetic dependencies have on cell viability. Supplementary Figure S6. Correlation analysis displaying features that correlated most significantly with sgRNA potency. Supplementary Figure S7. Effect of relative position within a gene on sgRNA viability effects. Supplementary Figure S8. Non-scoring sgRNA in conserved Pfam domains have a reduced editing efficiency compared to guides with strong viability effects. Supplementary Figure S9. Multiple genomic cuts result in DNA damage induced G2/M cell cycle arrest. Supplementary Figure S10. Multiple genomic cuts lead to an increase in cell death. Supplementary Figure S11. Pie chart demonstrating that the overall contribution of copy number effects in determining essential genes in aneuploid lines is relatively minor.&lt;/p&gt;
Minimum-cost coverage of point sets by disks (2006)

We consider a class of geometric facility location problems in which the goal is to determine a set X of disks given by their centers (tj) and radii (rj) that cover a given set of demand points Y∈R2 at the smallest possible cost. We consider cost functions of the form Εjf(rj), where f(r)=rα is the cost of transmission to radius r. Special cases arise for α=1 (sum of radii) and α=2 (total area); power consumption models in wireless network design often use an exponent α>2. Different scenarios arise according to possible restrictions on the transmission centers tj, which may be constrained to belong to a given discrete set or to lie on a line, etc.We obtain several new results, including (a) exact and approximation algorithms for selecting transmission points tj on a given line in order to cover demand points Y∈R2; (b) approximation algorithms (and an algebraic intractability result) for selecting an optimal line on which to place transmission points to cover Y; (c) a proof of NP-hardness for a discrete set of transmission points in R2 and any fixed α>1; and (d) a polynomial-time approximation scheme for the problem of computing a minimum cost covering tour (MCCT), in which the total cost is a linear combination of the transmission cost for the set of disks and the length of a tour/path that connects the centers of the disks.
Effects of plasma and vacuum-ultraviolet exposure on the mechanical properties of low-k porous organosilicate glass (2014)

The effects of plasma exposure and vacuum-ultraviolet (VUV) irradiation on the mechanical properties of low-k porous organosilicate glass (SiCOH) dielectric films were investigated. Nanoindentation measurements were made on SiCOH films before and after exposure to an electron-cyclotron-resonance plasma or a monochromatic synchrotron VUV beam, to determine the changes of film hardness, elastic modulus, and crack threshold due to these exposures. This permits the effects of ion bombardment and photon bombardment to be analyzed separately. The role of energetic ions was examined with a variety of inert plasma-exposure conditions. The role of VUV photons was analyzed as a function of synchrotron photon energy. It was found that both energetic ions and VUV photons with energies larger than the bond energy of the Si-O bond cause a significant increase in film hardness along with a smaller increase in elastic modulus and crack threshold. Differential Fourier transform infrared spectra and x-ray photoemission spectroscopy results show that the energetic ions affect the SiCOH properties mainly through physical bombardment, during which the ions transfer their momentum to the Si-O-Si backbone and transform them into more energetically stable Si-O-Si network structures. This results in the Si-O-Si network structures becoming densified. VUV photons assist reaction that increase the number of bridging O3≡Si-O-Si≡O3 bonds and deplete nonbridging O3≡Si-O and C-Si≡O3 bonds. This increased degree of cross linking in porous organosilicate dielectrics can substantially enhance their hardness and elastic modulus while showing no significant film shrinkage or densification.
Self-Assembled Extracellular Macromolecular Matrices and Their Different Osteogenic Potential with Preosteoblasts and Rat Bone Marrow Mesenchymal Stromal Cells (2012)

Extracellular environment is a physical support that is critical to cell adhesion, migration, and differentiation. In this work, cell-derived matrices (CDMs) were obtained by separately culturing fibroblasts, preosteoblasts, and chondrocytes. The cells were grown on a coverslip and subjected to decellularization using detergents and enzymes. The resulting matrices were named fibroblast-derived matrix (FDM), preosteoblast-derived matrix (PDM), and chondrocyte-derived matrix (CHDM). We hypothesize that the unique compositional and structural feature of each CDM provides cells with a distinct microenvironment capable of functioning as a different signaling cue in the regulation of preosteoblast and rat bone marrow mesenchymal stromal cell (BMSC) osteogenic differentiation. SEM images show that each cell type creates its unique surface texture in a fibrillar structure. Three major macromolecules, fibronectin, type I collagen, and laminin, were clearly identified using both immunofluorescence and Western blot, in which FDM exhibited a much stronger signal of each ECM component than that of PDM or CHDM. For early cell morphology, BMSCs on the CDMs were highly elongated in a spindle-like shape. Both preosteoblasts and BMSCs proliferated well on CDMs comparable to the control. Once preosteoblasts were cultured for 2 weeks, their osteogenic activity was significantly different depending on the type of CDM. Using Alizarin red and von Kossa staining, we found that the cells on the FDM were much more osteogenic than the other groups. Furthermore, FDM was the most effective in upregulating the osteogenic markers, such as alkaline phosphatase (ALP), osteopontin, osteocalcin, and type I collagen. In particular, we observed a 2.5-fold increase in ALP activity with FDM compared to that of control and CHDM. In stark contrast, CHDM was very poor in stimulating osteogenic differentiation of preosteoblasts. Interestingly, these results were reproducible with the use of BMSCs, which are much more heterogeneous in cell populations than preosteoblasts. CHDM was still very weak in triggering the osteogenesis of BMSCs, whereas both FDM and PDM were equally competitive. This study demonstrates that a combination of factors (surface texture and composition) shape a unique cellular microenvironment, which serves as a physical cue toward the osteogenic differentiation of preosteoblasts and BMSCs.
The Structure and Dielectric Properties of Plasma-Polymerized Benzene and OFCB Thin Films (Preprint) (2006)

Polymeric dielectric and photonic thin films can be fabricated using plasma enhanced chemical vapor deposition (PECVD), a room temperature, solvent-free and versatile technique. Many organic precursors have been deposited yielding plasma polymerized thin films with a wide range of functionalities. These films, exhibiting highly cross-linked structures, pin-hole free bulk morphologies and smooth surfaces for a variety of film thicknesses, have been targeted for optical and dielectric applications such as waveguides, AR coatings, band-gap filters for integrated optics, and high performance dielectric devices. In this work, benzene and octafluorocyclobutane (OFCB) were chosen as starting precursors for exploring the relationship between structure and dielectric properties.
A Clinical Impact Classification of Scoliosis in the Adult (2006)

A clinical impact classification has been established based on radiographic markers of disability. The classification has shown correlation with self-reported disability as well as rates of operative treatment.
Deep Q-Learning-Based Resource Allocation in NOMA Visible Light Communications (2022)

Visible light communication (VLC) has been introduced as a key enabler for high-data rate wireless services in future wireless communication networks. In addition to this, it was also demonstrated recently that non-orthogonal multiple access (NOMA) can further improve the spectral efficiency of multi-user VLC systems. In this context and owing to the significantly promising potential of artificial intelligence in wireless communications, the present contribution proposes a deep Q-learning (DQL) framework that aims to optimize the performance of an indoor NOMA-VLC downlink network. In particular, we formulate a joint power allocation and LED transmission angle tuning optimization problem, in order to maximize the average sum rate and the average energy efficiency. The obtained results demonstrate that our algorithm offers a noticeable performance enhancement into the NOMA-VLC systems in terms of average sum rate and average energy efficiency, while maintaining the minimum convergence time, particularly for higher number of users. Furthermore, considering a realistic downlink VLC network setup, the simulation results have shown that our algorithm outperforms the genetic algorithm (GA) and the differential evolution (DE) algorithm in terms of average sum rate, and offers considerably less run-time complexity.
ESR-, ENDOR- und TRIPLE-Untersuchungen zur Tieftemperaturkonformation von Phenoxylsystemen / Studies of the Low Temperature Conformation of Phenoxyls by ESR, ENDOR and TRIPLE-Resonance (1984)

In a series of ortho- and para-substituted phenoxyls the coupling of the β-nuclei (H and P) is caused by hyperconjugation and π-σ-mechanisms, leaving open the signs of the combined HFS constants. By examining the ENDOR and TRIPLE spectra these couplings turned out to be negative. Thus the sign of the well known temperature gradient of these parameters, due to hindered rotation of the substituted group, is positive, leading to a planar conformation of the radicals at low temperature.
In vivo laser Doppler holography of the human retina (2018)

The eye offers a unique opportunity for the non-invasive exploration of cardiovascular diseases. Optical angiography in the retina requires sensitive measurements, which hinders conventional full-field laser Doppler imaging schemes. To overcome this limitation, we used digital holography to perform laser Doppler perfusion imaging of human retina with near-infrared light. Two imaging channels with a slow and a fast CMOS camera were used simultaneously for real-time narrowband measurements, and offline wideband measurements, respectively. The beat frequency spectrum of optical interferograms recorded with the fast (up to 75 kHz) CMOS camera was analyzed by short-time Fourier transformation. Power Doppler images drawn from the Doppler power spectrum density qualitatively revealed blood flow in retinal vessels over 512 × 512 pixels covering 2.4 × 2.4 mm<sup>2</sup> on the retina with a temporal resolution down to 1.6 ms. The sensitivity to lateral motion as well as the requirements in terms of sampling frequency are discussed.
Prognostic value of human mature adrenomedullin in patients with acute myocardial infarction (2016)

Adrenomedullin (ADM) correlates with adverse cardiovascular outcomes in patients with acute myocardial infarction (AMI) and in patients with heart failure. Measurement of human mature ADM (mADM) has been difficult, and recent studies have used its surrogate - the mid-regional pro-ADM (MRproADM). Our objective was to determine whether mADM measured by a novel sandwich immunoassay, using the anti-C-terminal and an anti-mid-regional monoclonal antibody, was prognostic of 30-day, 90-day, 1-year, and 2-year major adverse cardiovascular events (MACEs) in 1111 consecutive patients who have suffered an AMI. We also compared it with the effect of MRproADM in the same patient population. A total of 311 (27.0%) patients experienced the primary endpoint at 2 years follow-up. The median (inter-quartile range) of mADM was significantly higher in patients who experienced a 2-year MACE [60.90 (44.00-86.97)] pg/ml, compared to event-free survivors [49.59 (36.20-68.15)] pg/ml (P < 0.001). mADM, taken as 1 SD of the continuous variable, was predictive of MACEs in multivariate analysis, with hazard ratios [95% confidence intervals (CIs)] at 90 days [1.28 (1.01-1.62)], 1 year [1.31 (1.08-1.59)], and 2 years [1.42 (1.07-1.64)]. It was also independently predictive of death at 1-year [1.52 (1.12-2.05)] and 2-year [1.42 (1.07-1.89)] follow-up. mADM was a better predictor of these outcomes than MRproADM, apart from death at 90 days, and combined death and heart failure hospitalization at 1 and 2 years, respectively. Human mADM can be reliably measured and predicts MACE events at medium-term follow-up, and confirms the paradigm of risk stratification using MRproADM - a surrogate for the active hormone. The relationship between mADM and MACE appears to be a continuum.
Role of the Regulatory Gene pl in the Photocontrol of Maize Anthocyanin Pigmentation (1993)

Karen C. Cone, Suzy M. Cocciolone, Cynthia A. Moehlenkamp, Timothy Weber, Bruce J. Drummond, Laura A. Tagliani, Benjamin A. Bowen, Gary H. Perrot, Role of the Regulatory Gene pl in the Photocontrol of Maize Anthocyanin Pigmentation, The Plant Cell, Vol. 5, No. 12 (Dec., 1993), pp. 1807-1816
Psychosexual Adjustment and Counseling After Myocardial Infarction (1980)

The current trend in cardiac rehabilitation is toward the empirical and systematic evaluation of the effectiveness of general and specific components. Clearly, resumption of sexual activity is important to the rehabilitation of patients and their partners. In fact, resumption of sexual behavior may be therapeutic in solidfying the marital relationship during stressful readjustment periods. A satisfying sexual relationship can be valuable as a step towards fostering self-confidence and a feeling of returning health. The cardiac rehabilitation program should strive for a multidisciplinary team approach and to initiate intervention and counseling as early as medically possible during the hospitalization. Counseling programs should always include the exploration of the possible concerns of patients and their partners about resumption of sexual activity. Patients should be advised as to the realities of their fears and provided with guidelines for facilitating a satisfying sexual relationship.
An extrinsic-inductance independent approach for direct extraction of HBT intrinsic circuit parameters (2001)

A novel analytical procedure has been proposed for direct extraction of the intrinsic elements in a hybrid-/spl pi/ equivalent circuit of heterojunction bipolar transistors. This method differs from previous ones by formulating impedance-parameter based expressions that are exclusive of the extrinsic inductances associated with the base, emitter, and collector. It is therefore not susceptible to variation of the extrinsic reactances from DC to high frequencies and can lead to very accurate extraction of the intrinsic elements under different bias conditions. The distributed phenomena in the base region can be also characterized rigorously by exploiting the bias-independent features of the extrinsic elements that are extracted subsequently from knowledge of the intrinsic elements.
Leader selection games under link noise injection attacks (2012)

In a leader-follower multi-agent system, the states of a set of leader agents are controlled directly by the system owner and used to influence the behavior of the remaining follower agents. When deployed in hostile environments, leader-follower systems may be disrupted by adversaries introducing noise in the communication links between agents through interference or false packet insertion, thus corrupting the states of the follower agents. In this paper, we study the problem of mitigating the effect of noise injection attacks by selecting leader agents. We address two cases within a supermodular game-theoretic framework. In the first case, a fixed set of leaders is chosen when the system is initialized. We model this case as a Stackelberg game, in which the system moves first by choosing leaders in order to minimize the worst-case error and the adversary responds by introducing noise. In the second case, the set of leaders varies over time. We study the second case as a simultaneous-move game between the system and an adversary. We show that the game formulations for both cases have equilibria that can be approximated up to a provable bound using supermodular optimization techniques. We illustrate our approach via simulations.
Design of a lightweight magnetizer to enable a portable circumferential magnetic flux leakage detection system (2019)

We proposed a lightweight magnetizer toward the realization of a portable circumferential magnetic flux leakage (MFL) inspection tool for the detection of longitudinal defects with a linear motion between pipes and the inspection tool. The proposed magnetizer consists of four permanent magnetic poles constructing a configuration in which the like poles are separated by a θ angle ranging from 30° to 60° and the opposite poles are separated by a supplemental angle of θ. The distribution of the magnetic field generated by this magnetizer and caused by defects was studied by finite element methods as well as by experimental measurements. The results reveal that the new magnetizer has advantages of high amplitude and good uniformity of magnetic field over the state-of-the-art ones with configurations of two facing poles or quadrupole geometries. With the new magnetizer, the theoretical and experimental results show that the magnetization in the pipe increases slightly with the θ angle, but the uniformity of magnetization in the pipe and the magnetic field on the surface of pipe decrease dramatically with this angle. So, the optimum angle θ is proposed at around 30°-40°. The finite element calculation and the measurements of the MFL signal caused by artificial defects evidence the capabilities in detecting shallow longitudinal defects of the MFL inspection tool with our novel magnetizer.
Microstructure variability and macroscopic composite properties of high performance fiber reinforced cementitious composites (2005)

High performance fiber reinforced cementitious composites have made major advances in recent years, to the point where they are being adopted in building and bridge constructions. The most significant advantage of HPFRCC over conventional concrete is their high tensile ductility. However, the tensile strain capacity has been observed to vary, most likely as a result of the variability of the microstructure derived from the processing of these materials. This paper describes the composite property variability, as well as the variability of the material microstructure. Scale linkage is discussed. In particular, the tensile stress–strain curves, and the crack pattern on uniaxially loaded specimens are presented. The treatment of random fibers in micromechanical models, and tailoring of matrix flaw size distribution for saturated multiple cracking are examined. It is suggested that robust composite properties can be achieved by deliberate control of microstructure variability. Some open issues concerning the randomness of microstructures and possibly related macroscopic behavior are also identified. Further gains in composite property control may be expected from improvements in characterization and modeling of the microstructure randomness.
Balanced switching converter to reduce common-mode conducted noise (2003)

Because conventional switching converters have usually used unbalanced circuit topologies, parasitic capacitance between the drain/collector of an active switch and the frame ground through its heat sink may generate the common-mode conducted noise. This paper proposes a balanced switching converter circuit, which is an effective way to reduce the common-mode conducted noise. As an example, a boost converter version of the balanced switching converter is presented, and the mechanism of the common-mode noise reduction is explained using an equivalent circuit. This good feature is confirmed by experimental results. The concept of the balanced switching converter is applied to some other types of switching converters.
Phase 1/2 study of fractionated dose lutetium‐177–labeled anti–prostate‐specific membrane antigen monoclonal antibody J591 ( 177 Lu‐J591) for metastatic castration‐resistant prostate cancer (2019)

Fractionated administration of <sup>177</sup> Lu-J591 allowed higher cumulative radiation dosing. The frequency and depth of PSA decrease, overall survival, and toxicity (dose-limiting myelosuppression) increased with higher doses.