gebhart/patrepeval huggingface dataset:
Silicone Rubber Replacement of the Severely Fractured Radial Head (1994)

The best method of treatment for displaced comminuted fractures of the radial head is still controversial. Early excision of the fractured radial head has been favored by a number of authors. but problems such as chronic pain in the elbow, forearm or wrist, restricted movement of the elbow, late subluxation of the distal radio-ulnar joint can ensue. So prosthetic replacement of the radial head had been advocated either for acute treatment of a fracture or for delayed treatment, when conservative treatment has failed. We analyzed 10 patients with comminuted radial head fracture treated by silastic prosthesis replacement shortly after injury from Jan. 1988 to Dec. 1992. The results were as follows. l. Age distribution at operation was varied from 19 to 57 year with the average at 40.9 year. 2. The average time interval between initial radial head fracture and silastic prosthetic replacement was about 10 days(range 4 days to 18 days) 3. 6 patients(60%) were free of elbow, pain 2 patients(20%) had intermittent mild pain especially at night and 2 patients(20%) had mild pain only after heavy work. 4. All patients were free of wrist pain. 5. There was no patient of breaking or tilting of prosthesis radiologically. 6. Overall assessment showed excellent in 4 patients (40%), good in 4 patients(40%) and poor in 2 patients (20%).
Composite Polymer Core–Ceria Shell Abrasive Particles during Oxide CMP: A Defectivity Study (2008)

Ceria-based and fumed silica-based systems are compared for oxide chemical mechanical polishing (CMP) in terms of defectivity and removal rate (RR). Ceria-based slurries yield RR ca. threefold that of conventional silica slurries but result in enhanced defectivity. To reduce defectivity, composite structures comprising a 300 nm polymer core coated by 14 nm ceria particles have been investigated. The polymer core shows mechanical properties that are highly tunable by variation of synthesis parameters, while the major advantage of the ceria coating is an enhanced chemical action of the abrasive particles. We report the evolution of RR, root-mean-square roughness, and defects during silica CMP experiments using different abrasive types at pH 3 and 10. Interestingly, the two types of composites, achieved by either silane coupling agents or electrostatic attractive interactions between the core and the coating, exhibit different RR. This is attributed to differences in morphology and surface composition. Overall, the ceria composites result in reduced defectivity after CMP due to the springlike effect coming from the elastic component of the core, compared with conventional slurry material.
Noncontact precision measurement system (1990)

A gage is being developed to make precision measurements of moving surfaces in a manufacturing environment. A prototype has demonstrated submicron repeatability and accuracy at the 2- to 6-micron level as well as the ability to measure parts moving at about 1 in./min. The system is described, and the means to make the accuracy comparable to the repeatability and to increase part velocity to more than 200 in./min are indicated.
Serine Hydrolase KIAA1363:  Toxicological and Structural Features with Emphasis on Organophosphate Interactions (2006)

Serine hydrolase KIAA1363 is highly expressed in invasive cancer cells and is the major protein in mouse brain diethylphosphorylated by and hydrolyzing low levels of chlorpyrifos oxon (CPO) (the activated metabolite of a major insecticide). It is also the primary CPO-hydrolyzing enzyme in spinal cord, kidney, heart, lung, testis, and muscle but not liver, a pattern of tissue expression confirmed by fluorophosphonate-rhodamine labeling. KIAA1363 gene deletion using homologous recombination reduces CPO binding, hydrolysis, and metabolism 3-29-fold on incubation with brain membranes and homogenates determined with 1 nM [(3)H-ethyl]CPO and the inhibitory potency for residual CPO with butyrylcholinesterase as a biomarker. Studies with knockout mice further show that KIAA1363 partially protects brain AChE and monoacylglycerol lipase from CPO-induced in vivo inhibition. Surprisingly, mouse brain KIAA1363 and AChE are similar in in vitro sensitivity to seven methyl, ethyl, and propyl but not higher alkyl OP insecticides and analogues, prompting structural comparisons of the active sites of KIAA1363 and AChE relative to OP potency and selectivity. Homology modeling based largely on the Archaeoglobus fulgidus esterase crystal structure indicates that KIAA1363 has a catalytic triad of S191, D348, and H378, a GDSAG motif, and an oxyanion hole of H113, G114, G115, and G116. Excellent selectivity for KIAA1363 is achieved on OP structure optimization with long alkyl chain substituents suggesting that KIAA1363 has larger acyl and leaving group pockets than those of AChE. KIAA1363 reactivates faster than AChE presumably due to differences in the uncoupling of the catalytic triad His upon phosphorylation. The structural modeling of KIAA1363 helps us understand OP structure-activity relationships and the toxicological relevance of this detoxifying enzyme.
Link Selection in Hybrid RF/VLC Systems under Statistical Queueing\n Constraints (2017)

The co-deployment of radio frequency (RF) and visible light communications\n(VLC) technologies has been investigated in indoor environments to enhance\nnetwork performances and to address specific quality-of-service (QoS)\nconstraints. In this paper, we explore the benefits of employing both\ntechnologies when the QoS requirements are imposed as limits on the buffer\noverflow and delay violation probabilities, which are important metrics in\ndesigning low latency wireless networks. Particularly, we consider a\nmulti-mechanism scenario that utilizes RF and VLC links for data transmission\nin an indoor environment, and then propose a link selection process through\nwhich the transmitter sends data over the link that sustains the desired QoS\nguarantees the most. Considering an ON-OFF data source, we employ the maximum\naverage data arrival rate at the transmitter buffer and the non-asymptotic\nbounds on data buffering delay as the main performance measures. We formulate\nthe performance measures under the assumption that both links are subject to\naverage and peak power constraints. Furthermore, we investigate the performance\nlevels when either one of the two links is used for data transmission, or when\nboth are used simultaneously. Finally, we show the impacts of different\nphysical layer parameters on the system performance through numerical analysis.\n
In situ Atomic Force Microscopy Imaging of Polymer Degradation in an Aqueous Environment (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIn situ Atomic Force Microscopy Imaging of Polymer Degradation in an Aqueous EnvironmentK. M. Shakesheff, M. C. Davies, C. J. Roberts, S. J. B. Tendler, A. G. Shard, and A. DombCite this: Langmuir 1994, 10, 12, 4417–4419Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/la00024a005https://doi.org/10.1021/la00024a005research-articleACS PublicationsRequest reuse permissionsArticle Views499Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficacy of an anti-CD7-ricin A chain immunoconjugate in a novel murine model of human T-cell leukemia. (1992)

In vivo efficacy testing of monoclonal antibody-based drugs specific for human leukemias is hampered by the paucity of suitable animal models, due in part to the inability of many anti-human monoclonal antibodies to cross-react with antigens expressed in animal tissues or cells. Moreover, human leukemic cells have proven difficult to establish in immunosuppressed mice except as solid tumors. We report here the establishment of a murine model for human leukemia displaying features of human disease, such as growth of malignant cells and localization of such cells to lymphoid compartments, and the effective depletion of leukemic cells from these mice by an immunoconjugate. Human T-leukemia cells (CEM) injected into cyclophosphamide-pretreated NIH-III mice engrafted in all mice (n = 41), with CEM cells detected in the bone marrow, spleen, and blood 4 weeks after injection. There was no evidence of solid tumors. Treatment of CEM-engrafted mice with 4A2-RTA30, an immunoconjugate of an anti-CD7 monoclonal antibody and ricin A chain (RTA30), resulted in a 100- to 200-fold overall depletion of CEM cells from the spleen and the bone marrow (P less than 0.02). This depletion was specific and toxin-dependent, as a control immunoconjugate had no demonstrable effect (P greater than 0.5). Depletion of CEM cells was also observed after treatment with unconjugated anti-CD7 mAb, but this effect was not significantly different from controls (P greater than 0.1). Therefore, significant depletion of CEM cells required the presence of the ricin A chain moiety. Further investigations revealed that CEM cells recovered from NIH-III mice expressed less CD7 antigen, but remained sensitive to subsequent in vitro exposure to 4A2-RTA30. In conclusion, we have established a model for studying the efficacy of immunoconjugates and have successfully depleted human T-leukemic cells from lymphoid tissues in immunodeficient mice by treatment with an anti-CD7-RTA30 immunoconjugate.
Complexation Constants of Lanthanide Ions with Poly(Methacrylic Acid) and its Copolymers (1987)

Abstract Complexation of some lanthanide ions with poly(methacrylic acid) and its copolymers was studied by potentiometric titration. Poly [methacrylic acid-co-oligo(ethylene oxide)methacrylate] and poly(methacrylic acid-co-acrylamide) formed tris-carboxylate coordinate lanthanide complexes with large overall complexation constants, while poly-(methacrylic acid)s and copolymer with higher content of the methacrylic acid residue formed bis-coordinate ones. It was concluded that the comonomer residues in the copolymer chains decreased the steric hindrance for the complexation and/or acted as co-coordinating groups of the carboxylic group to lanthanide ions. Very large positive and favorable entropy changes were observed for the complexation with poly(methacrylic acid) and its copolymers. This contribution of thermodynamic parameters to the complexation was contrary to that for the analogous monomeric methacrylic acid complex and is assumed to be induced by dehydration of the polymers through the lanthanide ion complexation.
Stable White Light Electroluminescence from Highly Flexible Polymer/ZnO Nanorods Hybrid Heterojunction Grown at 50°C (2010)

Stable intrinsic white light-emitting diodes were fabricated from c-axially oriented ZnO nanorods (NRs) grown at 50 degrees C via the chemical bath deposition on top of a multi-layered poly(9,9-dioctylfluorene-co-N-(4-butylpheneylamine)diphenylamine)/poly(9,9dioctyl-fluorene) deposited on PEDOT:PSS on highly flexible plastic substrate. The low growth temperature enables the use of a variety of flexible plastic substrates. The fabricated flexible white light-emitting diode (FWLED) demonstrated good electrical properties and a single broad white emission peak extending from 420 nm and up to 800 nm combining the blue light emission of the polyflourene (PFO) polymer layer with the deep level emission (DLEs) of ZnO NRs. The influence of the temperature variations on the FWLED white emissions characteristics was studied and the devices exhibited high operation stability. Our results are promising for the development of white lighting sources using existing lighting glass bulbs, tubes, and armature technologies.
Geometrical-based statistical macrocell channel model for mobile environments (2002)

We develop a statistical geometric propagation model for a macrocell mobile environment that provides the statistics of angle-of-arrival (AOA) of the multipath components, which are required to test adaptive array algorithms for cellular applications. This channel model assumes that each multipath component of the propagating signal undergoes only one bounce traveling from the transmitter to the receiver and that scattering objects are located uniformly within a circle around the mobile. This geometrically based single bounce macrocell (GBSBM) channel model provides three important parameters that characterize a channel: the power of the multipath components, the time-of-arrival (TOA) of the components, and the AOA of the components. Using the GBSBM model, we analyze the effect of directional antennas at the base station on the fading envelopes. The level crossing rate of the fading envelope is reduced and the envelope correlation increases significantly if a directional antenna is employed at the base station.
Orange Essential Oils Antimicrobial Activities against Salmonella spp. (2008)

Seven citrus essential oils (EOs) were screened by disc diffusion assay for their antibacterial act against 11 serotypes/strains of Salmonella. The 3 most active oils were selected to determine the minimal inhibitory concentration (MIC) against the same Salmonella. Orange terpenes, single-folded d-limonene, and orange essence terpenes all exhibited inhibitory activity against the Salmonella spp. on the disc diffusion assay. EOs were stabilized in broth by the addition of 0.15% (w/v) agar for performance of the MIC tests. Orange terpenes and d-limonene both had MICs of 1%. The most active compound, terpenes from orange essence, produced an MIC that ranged from 0.125% to 0.5% against the 11 Salmonella tested. Gas chromatography-mass spectrometry (GC/MS) analysis revealed that this orange essence oil was composed principally of d-limonene, 94%, and myrcene at about 3%. EOs from citrus offer the potential for all natural antimicrobials for use in improving the safety of organic or all natural foods.
Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma (2020)

Refractory metastatic rhabdomyosarcoma is largely incurable. Here we analyze the response of a child with refractory bone marrow metastatic rhabdomyosarcoma to autologous HER2 CAR T cells. Three cycles of HER2 CAR T cells given after lymphodepleting chemotherapy induces remission which is consolidated with four more CAR T-cell infusions without lymphodepletion. Longitudinal immune-monitoring reveals remodeling of the T-cell receptor repertoire with immunodominant clones and serum autoantibodies reactive to oncogenic signaling pathway proteins. The disease relapses in the bone marrow at six months off-therapy. A second remission is achieved after one cycle of lymphodepletion and HER2 CAR T cells. Response consolidation with additional CAR T-cell infusions includes pembrolizumab to improve their efficacy. The patient described here is a participant in an ongoing phase I trial (NCT00902044; active, not recruiting), and is 20 months off T-cell infusions with no detectable disease at the time of this report.
Paclitaxel and pegylated liposomal doxorubicin in recurrent head/neck cancer: An unexpected administration interval-dependent pharmacokinetic interaction (2006)

2042 Background: Combination of paclitaxel (PTX) with pegylated liposomal doxorubicin (PLD) is an interesting opportunity for recurrent head/neck cancer treatment. Their pharmacokinetic (PK) behavior could be dependent not only on PTX excipient (polyethoxylated castor oil) interference, but also on different iv administration interval between the two drugs. The study endpoint was to evaluate any possible administration interval-dependent PK interaction, when PLD infusion start is delayed from 0 to 24 h after PTX infusion end. Methods: 24 patients affected by recurrent cisplatin pre-treated squamous cellhead/neck cancer were enrolled, receiving PTX 80 mg/m 2 q 1w and PLD 12.5 mg/m 2 q 2w for 6w/2w rest. Administration interval was 0 h at d1 (PTX-PLD 0) and 24 h at d15 (PTX-PLD 24). Blood sampling was performed at d1–15, PTX and PLD blood levels were analyzed by high performance liquid chromatography techniques, while PK parameters by non-compartmental analysis. Results: PTX PK parameters had large statistically significant differences (median/IQR, PTX-PLD 0 vs. PTX-PLD 24, Mann-Whitney test): Cmax 261/219–531 vs. 407/250–1473 ng/ml p=0.142, AUC 869/688–1331 vs. 3361/969–7853 ng*h/ml p=0.013, Kel 0.39/0.26–0.57 vs. 0.11/0.02–0.26 h⁁ −1 p=0.001, Cl 153/89–198 vs. 41/17–138 l/h p=0.013. Similarly, PLD Cmax and AUC were higher in PTX-PLD 24 (Cmax 5.1/3.3–8.1 vs. 6.8/5.3–7.8 mg/l p=0.043, AUC 341/104–1472 vs. 603/106–1006 mg*h/l p=1.000). The overall response rate was 37.5%, including 1 CR (4%); median response duration was 5.5 months (range, 2–16), median overall survival 10 months (range, 2–25+). Conclusions: This exploratory study, having a favourable palliative role in heavily pre-treated patients, showed that PTX PK profile is unexpectedly affected by a different administration interval. In PTX-PLD 0, PTX AUC is fourfold reduced, with a similar increase in Cl, totally due to Kel alteration: therefore, patients could be underexposed to PTX. PLD PK behavior confirmed previous studies results, in which PTX modified PLD disposition, prolonging the duration of its elimination phase and increasing total body exposure to PLD. No significant financial relationships to disclose.
Effects of UVR and UVR-induced Cytokines on Production of Extracellular Matrix Proteins and Proteases by Dermal Fibroblasts Cultured in Collagen Gels¶ (2004)

Synthesis of extracellular matrix (ECM) proteins and their degradation by matrix metalloproteinases (MMP) are part of the dermal remodeling resulting from chronic exposure of skin to ultraviolet radiation (UVR). We have compared two alternative mechanisms for these responses, namely, a direct mechanism in which UV-B or UV-A is absorbed by fibroblasts and an indirect mechanism in which cytokines, produced in skin in response to UVR, stimulate production of the ECM proteins and MMP. These studies were carried out on human dermal fibroblasts grown in contracted, free-floating 9 day old collagen gels as a dermal equivalent. Synthesis of tropoelastin, collagen, fibrillin, MMP-1, -2, -3 and -9 and tissue inhibitors of metalloproteinases (TIMP)-1 and -2 were measured. Tropoelastin, collagen and fibrillin levels were stable between days 4 and 10, and MMP and TIMP decreased by day 10. Neither UV-B (2.5–50 mJ/cm2) nor UV-A (2–12 J/cm2) altered synthesis of ECM proteins, but UV-A increased MMP-1 and -3 production. Tropoelastin synthesis increased in response to transforming growth factor-β1 (5 ng/mL) treatment. Both interleukin-1β and tumor necrosis factor-α (10 ng/mL) decreased fibrillin messenger RNA levels but increased MMP-1, -3 and -9 synthesis markedly. Collagen synthesis was not modulated by UV-B, UV-A or cytokine treatment. These results indicate that certain cytokines may have greater effects on production of ECM proteins and MMP than absorption of UV-B and UV-A by fibroblasts grown in dermal equivalents and suggest that the former pathway may play a role in the dermal remodeling in photoaged skin.
In-vitro efficacy of different platelet glycoprotein IIb/IIIa antagonists and thrombolytics on platelet/fibrin-mediated clot dynamics in human whole blood using thrombelastography (2006)

Suppressing platelet activation improves efficacy of thrombolytic therapy for stroke and acute myocardial infarction. Combination treatment with recombinant tissue plasminogen activator (r-tPA) and glycoprotein IIb/IIIa (GPIIb/IIIa) inhibitor that binds with high affinity to platelets may therefore improve the efficacy of thrombolytic therapy. The effect of platelet GPIIb/IIIa antagonists and/or r-tPA on the dynamics of platelet/fibrin clot formation, strength, and lysis was determined using thrombelastography in human blood under thrombin or tissue factor stimulation. The study utilized platelet GPIIb/IIIa antagonists with high affinity and slow off-rate (Class I) from resting and activated platelets in comparison with Class II antagonists (lower affinity and fast off-rate from platelet GPIIb/IIIa receptors). The combination of the active form of roxifiban (XV459; Class I) or the active form of orbofiban (Class II) with a subeffective concentration of r-tPA resulted in a synergistic effect in clot lysis with roxifiban active form XV459 but not with that of orbofiban at therapeutically achievable concentrations that inhibit human platelet aggregation. These data indicate differential enhanced thrombolysis of low levels of r-tPA with high-affinity Class I but not with low-affinity Class II GPIIb/IIIa antagonists in the absence of anticoagulants.
Exploiting Silhouette Descriptors and Synthetic Data for Hand Gesture Recognition (2015)

This paper proposes a novel real-time hand gesture recognition scheme explicitly targeted to depth data. The hand silhouette is firstly extracted from the acquired data and then two ad-hoc feature sets are computed from this representation. The first is based on the local curvature of the hand contour, while the second represents the thickness of the hand region close to each contour point using a distance transform. The two feature sets are rearranged in a three dimensional data structure representing the values of the two features at each contour location and then this representation is fed into a multi-class Support Vector Machine. The classifier is trained on a synthetic dataset generated with an ad-hoc rendering system developed for the purposes of this work. This approach allows a fast construction of the training set without the need of manually acquiring large training datasets. Experimental results on real data show how the approach is able to achieve a 90% accuracy on a typical hand gesture recognition dataset with very limited computational resources.