gebhart/patrepeval huggingface dataset:
The roles of surface chemistry, dissolution rate, and delivered dose in the cytotoxicity of copper nanoparticles (2017)

The understanding of nanoparticle (NP) cytotoxicity is challenging because of incomplete information about physicochemical changes particles undergo once they come into contact with biological fluids. It is therefore essential to characterize changes in NP properties to better understand their biological fate and effects in mammalian cells. In this paper, we present a study on the effect of particle surface oxidation and dissolution rates of Cu NPs. Particle dissolution, cell-associated Cu doses, and oxidative stress responses in A549 luciferase reporter cells were examined for Cu NPs modified with mercaptocarboxylic acids with different carbon chain lengths and a thiotic acid appended-PEG ligand (TA). We found that these Cu NPs released ionic species together with small particles upon oxidation and that surface chemistry influenced the morphology and dissolution rate. The dissolution rate was also shown to impact both the cellular Cu dosimetry and associated oxidative stress responses. The convergent results from dissolution and dosimetry measurements demonstrate that both intracellular and extracellular (i.e., NP uptake-independent) release of ionic species from Cu NPs greatly affect the cytotoxicity.
In Vitro and in Vivo Characterization of 3-{2-[6-(2-tert-Butoxyethoxy)pyridin-3-yl]-1H-imidazol-4-yl}benzonitrile Hydrochloride Salt, a Potent and Selective NPY5 Receptor Antagonist (2003)

To investigate the anorectic potential of NPY5 receptor antagonists, we have profiled the in vitro and in vivo properties of 3-[2-[6-(2-tert-butoxyethoxy)pyridin-3-yl]-1H-imidazol-4-yl]benzonitrile hydrochloride salt (1). This compound was found to have excellent NPY5 receptor affinity and selectivity, potent functional antagonism, and good peripheral and central nervous system exposure in rats. This compound attenuated bovine pancreatic polypeptide induced food intake in rats but failed to demonstrate anorectic activity in rodent natural feeding models.
An Applicator-Shaped Scleral Depressor for Vitreoretinal Surgery (1997)

This article describes an instrument that combines a standard T-shaped scleral depressor at one end with a cotton applicator-shaped depressor at the other end. The applicator-shaped depressor has a matted surface to prevent slippage. This simple instrument has several advantages over depressors now available for intraoperative use.
On the Convergence of Approximate Message Passing With Arbitrary Matrices (2014)

Approximate message passing (AMP) methods and their variants have attracted considerable recent attention for the problem of estimating a random vector x observed through a linear transform A. In the case of large i.i.d. A, the methods exhibit fast convergence with precise analytic characterizations on the algorithm behavior. However, the convergence of AMP under general transforms is not fully understood. In this paper, we provide sufficient conditions for the convergence of a damped version of the generalized AMP (GAMP) algorithm in the case of Gaussian distributions. It is shown that, with sufficient damping the algorithm can be guaranteed to converge, but the amount of damping grows with peak-to-average ratio of the squared singular values of A. This condition explains the good performance of AMP methods on i.i.d. matrices, but also their difficulties with other classes of transforms. A related sufficient condition is then derived for the local stability of the damped GAMP method under more general (possibly non-Gaussian) distributions, assuming certain strict convexity conditions.
Human Amniotic Membrane for the Prevention of Intradural Spinal Cord Adhesions: Retrospective Review of its Novel Use in a Case Series of 14 Patients (2017)

This first-in-human series provides evidence that HAM grafts are a safe and potentially efficacious method for preventing retethering after microsurgical intradural lysis of adhesions. These results lay the groundwork for further prospective controlled trials in patients with this difficult-to-treat pathology.
Perioperative Clopidogrel and Postoperative Events after Hip and Knee Arthroplasties (2012)

Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
Human Herpesvirus-6 Detection in Cerebrospinal Fluid on the BioFire FilmArray Meningitis/Encephalitis Panel in a High Human Immunodeficiency Virus-Prevalence African Setting (2022)

The prevalence and clinical relevance of human herpesvirus-6 (HHV-6) detection in cerebrospinal fluid (CSF) using multiplex polymerase chain reaction (PCR) testing in patients with suspected meningoencephalitis in high human immunodeficiency virus-prevalence African settings are not known. We describe the clinical and laboratory characteristics of 13 patients with HHV-6 CSF PCR positivity in Botswana.
ChemInform Abstract: Preparation of Stabilized Nanosized Tin Oxide Particles by Hydrothermal Treatment. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Depletion-mode polysilicon optical modulators in a bulk complementary metal-oxide semiconductor process (2013)

We demonstrate depletion-mode carrier-plasma optical modulators fabricated in a bulk complementary metal-oxide semiconductor (CMOS), DRAM-emulation process. To the best of our knowledge, these are the first depletion-mode modulators demonstrated in polycrystalline silicon and in bulk CMOS. The modulators are based on novel optical microcavities that utilize periodic spatial interference of two guided modes to create field nulls along waveguide sidewalls. At these nulls, electrical contacts can be placed while preserving a high optical Q. These cavities enable active devices in a process with no partial silicon etch and with lateral p-n junctions. We demonstrate two device variants at 5 Gbps data modulation rate near 1610 nm wavelength. One design shows 3.1 dB modulation depth with 1.5 dB insertion loss and an estimated 160 fJ/bit energy consumption, while a more compact device achieves 4.2 dB modulation depth with 4.0 dB insertion loss and 60 fJ/bit energy consumption. These modulators represent a significant breakthrough in enabling active photonics in bulk silicon CMOS--the platform of the majority of microelectronic logic and DRAM processes--and lay the groundwork for monolithically integrated CMOS-to-DRAM photonic links.
METIS (2016)

Today, students are offered a wide variety of alternatives to printed material for the consumption of educational content. Previous research suggests that, while digital content has its advantages, printed content still offers benefits that cannot be matched by digital media. This paper introduces the Meaningful Education and Training Information System (METIS), a multi-faceted hybrid book learning platform. The goal of the system is to provide an easy digital-to-print-to-digital content creation and reading service. METIS incorporates technology for layout, personalization, co-creation and assessment. These facilitate and, in many cases, significantly simplify common teacher/student tasks. Our system has been demonstrated at several international education events, partner engagements, and pilots with local universities and high schools. We present the system and discuss how it enables hybrid learning.
Comparative Analysis of Individuals With and Without Chiropractic Coverage (2004)

Access to managed chiropractic care may reduce overall health care expenditures through several effects, including (1) positive risk selection; (2) substitution of chiropractic for traditional medical care, particularly for spine conditions; (3) more conservative, less invasive treatment profiles; and (4) lower health service costs associated with managed chiropractic care. Systematic access to managed chiropractic care not only may prove to be clinically beneficial but also may reduce overall health care costs.
Efficacy of vision-based treatments for children and teens with amblyopia: a systematic review and meta-analysis of randomised controlled trials (2021)

We found no clinically relevant differences in treatment efficacy between the treatments included in this review. Adherence to the prescribed hours of treatment varied considerably and may have had an effect on treatment success.
Estimation of speech source direction for hearing aid application using smartphone (2017)

In our hearing aid research project funded by NIH-NIDCD we utilize smartphone and its features as a powerful platform to implement complex signal processing algorithms which would improve hearing aid applications. Among the required algorithms, is finding the direction of arrival of speech source signals which can improve the performance of hearing aid devices for the users. In this poster presentation, a signal processing algorithm for estimating the speech source direction and its real-time implementation on an Android smartphone are demonstrated. The visual display of source direction on the smartphone panel can be used to align the phone and its two microphones in the right direction of source to enhance the signal to noise ratio and improve the reception of speech signal. A demo unit will be presented showing the real-time operation of the proposed method on an Android smartphone.
Supplementary Figure Legend from Mechanisms of Activity of the TORC1 Inhibitor Everolimus in Waldenstrom Macroglobulinemia (2023)

&lt;p&gt;PDF file - 38K&lt;/p&gt;
CuH-Catalyzed Regio- and Enantioselective Hydrocarboxylation of Allenes: Toward Carboxylic Acids with Acyclic Quaternary Centers (2021)

We report a method to prepare α-chiral carboxylic acid derivatives, including those bearing all-carbon quaternary centers, through an enantioselective CuH-catalyzed hydrocarboxylation of allenes with a commercially available fluoroformate. A broad range of heterocycles and functional groups on the allenes were tolerated in this protocol, giving enantioenriched α-quaternary and tertiary carboxylic acid derivatives in good yields with exclusive branched regioselectivity. The synthetic utility of this approach was further demonstrated by derivatization of the products to afford biologically important compounds, including the antiplatelet drug indobufen.
Hyper-NA EUV lithography: an imaging perspective (2023)

To print ever smaller features at high contrast projection lithography technology has evolved to shorter wavelength light and larger NA. After enabling the EUV wavelength, the industry is looking into increasing the NA. This study aims to identify EUV specific challenges regarding NA scaling beyond 0.55. We study if EUV imaging can still work at this higher NA and whether specific changes to the mask stack are required. At NA's much higher than 0.55, new effects like polarization will play a role, and larger impact of ultimate mask resolution and material interactions is expected. Already at NA 0.55, a small contrast loss is predicted due to the use of unpolarized light in the scanner. Further increasing the NA will enhance the contrast loss. We study these polarization effects in detail and assess their impact quantitatively for a set of generic building blocks. In addition, the larger incidence angles on mask when the NA increases above 0.55, will further enhance the M3D effects forcing additional mask changes. To enable proper imaging at high incidence angles, new mask architectures, that include changes in the EUV mask absorber and multilayer, will have to be tested using rigorous simulations.
Data from p53-Reactive T Cells Are Associated with Clinical Benefit in Patients with Platinum-Resistant Epithelial Ovarian Cancer After Treatment with a p53 Vaccine and Gemcitabine Chemotherapy (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; To conduct a phase I trial of a Modified Vaccinia Ankara vaccine delivering wild-type human p53 (p53MVA) in combination with gemcitabine chemotherapy in patients with platinum-resistant ovarian cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Patients received gemcitabine on days 1 and 8 and p53MVA vaccine on day 15, during the first 3 cycles of chemotherapy. Toxicity was classified using the NCI Common Toxicity Criteria and clinical response assessed by CT scan. Peripheral blood samples were collected for immunophenotyping and monitoring of anti-p53 immune responses.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Eleven patients were evaluated for p53MVA/gemcitabine toxicity, clinical outcome, and immunologic response. Toxicity: there were no DLTs, but 3 of 11 patients came off study early due to gemcitabine-attributed adverse events (AE). Minimal AEs were attributed to p53MVA vaccination. Immunologic and clinical response: enhanced &lt;i&gt;in vitro&lt;/i&gt; recognition of p53 peptides was detectable after immunization in both the CD4&lt;sup&gt;+&lt;/sup&gt; and CD8&lt;sup&gt;+&lt;/sup&gt; T-cell compartments in 5 of 11 and 6 of 11 patients, respectively. Changes in peripheral T regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSC) did not correlate significantly with vaccine response or progression-free survival (PFS). Patients with the greatest expansion of p53-reactive T cells had significantly longer PFS than patients with lower p53-reactivity after therapy. Tumor shrinkage or disease stabilization occurred in 4 patients.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; p53MVA was well tolerated, but gemcitabine without steroid pretreatment was intolerable in some patients. However, elevated p53-reactive CD4&lt;sup&gt;+&lt;/sup&gt; and CD8&lt;sup&gt;+&lt;/sup&gt; T-cell responses after therapy correlated with longer PFS. Therefore, if responses to p53MVA can be enhanced with alternative agents, superior clinical responses may be achievable. &lt;i&gt;Clin Cancer Res; 24(6); 1315–25. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Opportunistic gains of mobility in cellular data networks (2015)

In this paper, we assess the performance gains of mobility on the downlink of cellular data networks. These gains are only due to the elastic nature of traffic and thus observed even under a blind, fair scheduling scheme: data are more likely transmitted when users are close to the base stations, in good radio conditions. This phenomenon is further amplified by opportunistic scheduling schemes that exploit multi-user diversity. The results are based on the analysis of flow-level traffic models and validated by system-level simulations.
HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance (2016)

Adipose tissue hypoxia is an important feature of pathological adipose tissue expansion. Hypoxia-inducible factor-1α (HIF-1α) in adipocytes reportedly induces oxidative stress and fibrosis, rather than neoangiogenesis via vascular endothelial growth factor (VEGF)-A. We previously reported that macrophages in crown-like structures (CLSs) are both hypoxic and inflammatory. In the current study, we examined how macrophage HIF-1α is involved in high-fat diet (HFD)-induced inflammation, neovascularization, hypoxia, and insulin resistance using mice with myeloid cell-specific HIF-1α deletion that were fed an HFD. Myeloid cell-specific HIF-1α gene deletion protected against HFD-induced inflammation, CLS formation, poor vasculature development in the adipose tissue, and systemic insulin resistance. Despite a reduced expression of Vegfa in epididymal white adipose tissue (eWAT), the preadipocytes and endothelial cells of HIF-1α-deficient mice expressed higher levels of angiogenic factors, including Vegfa, Angpt1, Fgf1, and Fgf10 in accordance with preferable eWAT remodeling. Our in vitro study revealed that lipopolysaccharide-treated bone marrow-derived macrophages directly inhibited the expression of angiogenic factors in 3T3-L1 preadipocytes. Thus, macrophage HIF-1α is involved not only in the formation of CLSs, further enhancing the inflammatory responses, but also in the inhibition of neoangiogenesis in preadipocytes. We concluded that these two pathways contribute to the obesity-related physiology of pathological adipose tissue expansion, thus causing systemic insulin resistance.
Development of an identification system for location of free metallic particles in GIS based on analysis of Lamb waves (2009)

Abstract We investigated propagation properties of Lamb waves in a gas‐insulated switchgear (GIS) tank to diagnose insulation performance of GIS. The acoustic signals excited by a free metallic particle colliding with the tank sheath were measured using AE sensors. The wavelet transform was applied to decompose the wave data into its time–frequency components. As a result, difference of propagation properties of Lamb waves is clearly seen with different sizes of GIS tank. Based on the characteristics of Lamb waves, algorithms for location identification of a free metallic particle were examined in model GIS using two AE sensors. Herein, we propose a new system for location identification of a free metallic particle in GIS. Moreover, it is verified that the new identification system is suitable as a diagnostic technique for GIS. © 2009 Wiley Periodicals, Inc. Electr Eng Jpn, 167(3): 28–35, 2009; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20676
MEC/Cloud Orchestrator to Facilitate Private/Local Beyond 5G with MEC and Proof-of-Concept Implementation (2022)

The emergence of 5G-IoT opens up unprecedented connectivity possibilities for new service use cases and players. Multi-access edge computing (MEC) is a crucial technology and enabler for Beyond 5G, supporting next-generation communications with service guarantees (e.g., ultra-low latency, high security) from an end-to-end (E2E) perspective. On the other hand, one notable advance is the platform that supports virtualization from RAN to applications. Deploying Radio Access Networks (RAN) and MEC, including third-party applications on virtualization platforms, and renting other equipment from legacy telecom operators will make it easier for new telecom operators, called Private/Local Telecom Operators, to join the ecosystem. Our preliminary studies have discussed the ecosystem for private and local telecom operators regarding business potential and revenue and provided numerical results. What remains is how Private/Local Telecom Operators can manage and deploy their MEC applications. In this paper, we designed the architecture for fully virtualized MEC 5G cellular networks with local use cases (e.g., stadiums, campuses). We propose an MEC/Cloud Orchestrator implementation for intelligent deployment selection. In addition, we provide implementation schemes in several cases held by either existing cloud owners or private and local operators. In order to verify the proposal's feasibility, we designed the system level in E2E and constructed a Beyond 5G testbed at the Ōokayama Campus of the Tokyo Institute of Technology. Through proof-of-concept in the outdoor field, the proposed system's feasibility is verified by E2E performance evaluation. The verification results prove that the proposed approach can reduce latency and provide a more stable throughput than conventional cloud services.
Supplementary Table 1 from hTERT Is Expressed in Cancer Cell Lines Despite Promoter DNA Methylation by Preservation of Unmethylated DNA and Active Chromatin around the Transcription Start Site (2023)

Supplementary Table 1 from hTERT Is Expressed in Cancer Cell Lines Despite Promoter DNA Methylation by Preservation of Unmethylated DNA and Active Chromatin around the Transcription Start Site
Use of Resuscitation promoting factors to screen for tuberculosis infection in household-exposed children in The Gambia (2020)

Abstract Background Interferon-γ release assays (IGRA) with Resuscitation promoting factor (Rpf) proteins enhanced tuberculosis (TB) screening and diagnosis in adults but have not been evaluated in children. Children often develop paucibacillary TB and their immune response differs from that of adults, which together affect TB disease diagnostics and immunodiagnostics. We assessed the ability of Rpf to identify infection among household TB-exposed children in The Gambia and investigated their ability to discriminate Mycobacterium tuberculosis complex (MTBC) infection from active TB disease in children. Methods Detailed clinical investigations were done on 93 household TB-exposed Gambian children and a tuberculin skin test (TST) was administered to asymptomatic children. Venous blood was collected for overnight stimulation with ESAT-6/CFP-10-fusion protein (EC), purified protein derivative and RpfA, B, C, D and E. Interferon gamma (IFN-γ) production was measured by ELISA in supernatants and corrected for the background level. Infection status was defined by IGRA with EC and TB disease by mycobacterial confirmation and/or clinical diagnosis. We compared IFN-γ levels between infected and uninfected children and between infected and TB diseased children using a binomial logistic regression model while correcting for age and sex. A Receiver Operating Characteristics analysis was done to find the best cut-off for IFN-γ level and calculate sensitivity and specificity. Results Interferon gamma production was significantly higher in infected (IGRA+, n=45) than in uninfected (IGRA-, n=20) children after stimulation with RpfA, B, C, and D ( P = 0.03; 0.007; 0.03 and 0.003, respectively). Using RpfB and D-specific IFN-γ cut-offs (33.9 pg/mL and 67.0 pg/mL), infection was classified with a sensitivity-specificity combination of 73%-92% and 77%-72% respectively, which was similar to and better than 65%-75% for TST. Moreover, IFN-γ production was higher in infected than in TB diseased children (n=28, 5 bacteriologically confirmed, 23 clinically diagnosed), following RpfB and D stimulation ( P = 0.02 and 0.03, respectively). Conclusion RpfB and RpfD show promising results for childhood MTBC infection screening, and both performed similar to and better than the TST in our study population. Additionally, both antigens appear to discriminate between infection and disease in children and thus warrant further investigation as screening and diagnostic antigens for childhood TB.
Co-culture with mouse embryonic fibroblasts improves maintenance of metabolic function of human small hepatocyte progenitor cells (2020)

Derivation and culture of small hepatocyte progenitor cells (SHPCs) capable of proliferating <i>in vitro</i> has been described in rodents and recently in humans. These cells are capable of engrafting in injured livers, however, they display de-differentiated morphology and reduced xenobiotic metabolism activity in culture over passages. Here we report that SHPCs derived from adult primary human hepatocytes (PHHs) and cultured on mouse embryonic fibroblasts (MEFs) not only display differentiated morphology and exhibit gene expression profiles similar to adult PHHs, but importantly, they retain their phenotype over several passages. Further, unlike previous reports, where extensive manipulations of culture conditions are required to convert SHPCs to metabolically functional hepatocytes, SHPCs in our co-culture system maintain expression of xenobiotic metabolism-associated genes. We show that SHPCs in co-culture are able to perform xenobiotic metabolism at rates equal to their parent PHHs as evidenced by the metabolism of acetaminophen to all of its major metabolites. In summary, we present an improved co-culture system that allows generation of SHPCs from adult PHHs that maintain their differentiated phenotype over multiple passages. Our findings would be useful for expansion of limited PHHs for use in studies of drug metabolism and toxicity testing.