gebhart/patrepeval huggingface dataset:
Anks6(p.R823W) overexpression in kidney affects retinal degeneration (2017)

Eye disorders are associated with chronic kidney disease, so called renal-retinal syndrome. Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic disorders. ADPKD not only affects the renal function, but is also involved in the retinal vasoregression and neurodegeneration. Anks6 gene consists of 2655 bp coding for an 885-amino acid protein. Recently it has been shown that overexpression of Anks6 harbouring a missense mutation in the SAM domain in transgenic rats [TGR CMV-Anks6 (p.R823W)] causes polycystic kidney disease. The expression level of Anks6 (p.R823W) is tightly linked to the severity of the cystic phenotype. However, it is unclear if Anks6(p.R823W) overexpression links to retinal vascular and neuronal degeneration. Therefore, we use the TGR CMV-Anks6 (p.R823W) and study the retinal degeneration.
Photophysics and Redox Properties of Rylene Imide and Diimide Dyes Alkylated Ortho to the Imide Groups (2010)

Ruthenium-catalyzed C-H bond activation was used to directly attach phenethyl groups derived from styrene to positions ortho to the imide groups in a variety of rylene imides and diimides including naphthalene-1,8-dicarboximide (NMI), naphthalene-1,4:5,8-bis(dicarboximide) (NI), perylene-3,4-dicarboximide (PMI), perylene-3,4:9,10-bis(dicarboximide) (PDI), and terrylene-3,4:11,12-bis(dicarboximide) (TDI). The monoimides were dialkylated, while the diimides were tetraalkylated, with the exception of NI, which could only be dialkylated due to steric hindrance. The absorption, fluorescence, transient absorption spectra, and lowest excited singlet state lifetimes of these chromophores, with the exception of NI, are nearly identical to those of their unsubstituted parent chromophores. The reduction potentials of the dialkylated chromophores are approximately 100 mV more negative and oxidation potentials are approximately 40 mV less positive than those of the parent compounds, while the corresponding potentials of the tetraalkylated compounds are approximately 200 mV more negative and approximately 100 mV less positive than those of their parent compounds, respectively. Continuous wave electron paramagnetic resonance (EPR) and electron nuclear double resonance (ENDOR) data on the radical anion of PDI reveals spin density on the perylene-core protons as well as on the beta-protons of the phenethyl groups. The phenethyl groups enhance the otherwise poor solubility of the bis(dicarboximide) chromophores and only weakly perturb the photophysical and redox properties of the parent molecules, rendering these derivatives and related molecules of significant interest to solar energy conversion.
Adjacent channel interference aware channel assignment scheme for WLANs (2010)

As the deployment of wireless devices becomes widespread, the performance reduction due to interference between wireless channels incur a new research issue. Thus, the channel assignment scheme for reducing the interference is very important in IEEE 802.11-based Wireless LANs. However, most previous approaches have focused on 2.4GHz spectral band or have assumed that there is no interference between non-overlapping channels. In this paper, we investigate adjacent channel interference (ACI) between non-overlapping channels. We find out that the ACI has a great impact on the throughput performance via experimental results. We also propose a new channel assignment scheme which minimizes the ACI. The proposed scheme allocates the channel so as to maximize the system utilization based on the information of neighbor channel state. To evaluate the proposed scheme, we conduct extensive experiments on a wireless testbed. We also show that the proposed scheme achieves superior network performance.
METASTATIC FX'S: MAINTAINING QUALITY OF LIFE (2014)

The orthopaedist may need to act as an important adjunct to the oncologist in management of the cancer patient with hip disease. Management of the cancer patient with routine hip pathology may be relatively straightforward but the surgeon should note that the cancer patient may be on treatment protocols which affect wound healing, the immune system and the risk of DVT. The principles of managing metastatic disease include recognising the presence of lesions in bone about the hip, the occasional need for biopsy, the use of radiation in sensitive tumors and finally surgical stabilization or replacement when needed. In some cases percutaneous cementation of metastatic disease or radiofrequency ablation may be appropriate. Factors which can complicate management of patients who have completed treatment of peri-pelvic cancer, may include radiation therapy which can lead to osteonecrosis of the acetabulum. Greater than 500Cgy of radiation has been associated with high rates of acetabular fixation failure regardless of fixation type in several series. Decision making in these patients can be aided by consultation with previous radiation therapy providers to estimate the dose sustained by the local tissues under consideration. Increased rates of infection and wound healing have also been noted secondary to long term lymphatic obliteration caused by radiation. These concerns also affect the surgeon who must manage patients with acute metastatic disease where radiation and immune-compromise secondary to chemotherapy are often present.
Aging and decision making: A comparison between neurologically healthy elderly and young individuals (2003)

We report the results of experiments on economic decisions with two populations, one of healthy elderly individuals (average age 82) and one of younger students (average age 20). We examine confidence, decisions under uncertainty, differences between willingness to pay and willingness to accept and the theory of mind (strategic thinking). Our findings indicate that the older adults' decision behavior is similar to that of young adults, contrary to the notion that economic decision making is impaired with age. Choices over lotteries do not reflect the age differences previously reported in the psychology and biology literature. Moreover, some of the demonstrated decision behaviors suggest that the elderly individuals are less biased than the younger individuals.(1)There is a greater prevalence of overconfident behavior in the younger population. (2) Our results show no significant support for a theory of an endowment effect in either population. (3) Both populations perform similarly on the beauty contest task, although there is a modest indication of a higher incidence of confused behavior by the older.
First Synthesis of Bengazole A. (2000)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionFirst Synthesis of Bengazole A.Roger J. Mulder, Cynthia M. Shafer, and Tadeusz F. MolinskiCite this: J. Org. Chem. 2000, 65, 23, 8126Publication Date (Web):October 21, 2000Publication History Published online21 October 2000Published inissue 1 November 2000https://pubs.acs.org/doi/10.1021/jo004032ghttps://doi.org/10.1021/jo004032gcorrectionACS PublicationsCopyright © 2000 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views368Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (8 KB) Get e-Alertsclose Get e-Alerts
Sentence disambiguation by a shift-reduce parsing technique (1983)

Native speakers of English show definite and consistent preferences for certain readings of syntactically ambiguous sentences. A user of a natural-language-processing system would naturally expect it to reflect the same preferences. Thus, such systems must model in some way the linguistic performance as well as the linguistic competence of the native speaker. We have developed a parsing algorithm---a variant of the LALR(1) shift-reduce algorithm---that models the preference behavior of native speakers for a range of syntactic preference phenomena reported in the psycholinguistic literature, including the recent data on lexical preferences. The algorithm yields the preferred parse deterministically, without building multiple parse trees and choosing among them. As a side effect, it displays appropriate behavior in processing the much discussed garden-path sentences. The parsing algorithm has been implemented and has confirmed the feasibility of our approach to the modeling of these phenomena.
Search for a heavy narrow resonance decaying to eμ, eτ, or μτ with the ATLAS detector in s=7 TeV pp collisions at the LHC (2013)

This Letter presents the results of a search for a heavy particle decaying into an e , e , or final state in pp collisions at s = 7 TeV. The data were recorded with the ATLAS detector at the LHC during 2011 and correspond to an integrated luminosity of 4.6 fb -1 . No significant excess above the Standard Model expectation is observed, and exclusions at 95% confidence level are placed on the cross section times branching ratio for the production of an R-parity-violating supersymmetric tau sneutrino.
Supplementary Table S7 from Systematic Interrogation of 3q26 Identifies <i>TLOC1</i> and <i>SKIL</i> as Cancer Drivers (2023)

&lt;p&gt;Supplementary Table S7 - XLSX file 61K, List of shRNAs used in this study&lt;/p&gt;
Perioperative single-dose VEGF-C/D inhibitor enhances cardiac allograft survival and prevents chronic rejection by regulating lymphatic endothelial cell activation (2014)

Objectives: VEGF-C/D/VEGFR-3 signaling may regulate lymphatic vessel activation and the initiation of alloimmunity after transplantation. We investigated the effect of perioperative intracoronary injection of synthetic VEGF-C/D inhibitor on lymphatic vessel activation, antigen-presenting cell trafficking and subsequent development of alloimmune responses in rat cardiac allografts.
Plasmacytoid DCs are gentle guardians of tonsillar epithelium (2013)

The outcome of the interaction between plasmacytoid dendritic cells (pDCs) and bacteria has been very controversial: pDCs have been reported not to be activated by extracellular bacteria, to be activated but to only produce TNF-α and IL-6, or to be activated and produce IFN-α, the hallmark of pDC activation, but only if the bacteria have first been opsonized. In this issue of the European Journal of Immunology, Soumelis and colleagues [Eur. J. Immunol. 2013. 43: 1264-1273] unequivocally show that both blood and tonsillar pDCs are fully activated by bacteria and can produce IFN-α. They also show that pDCs are found in the stratified mucosal epithelium in human tonsils, and are "educated" by tonsillar epithelial cells not to release inflammatory cytokines, despite still being capable of activating T cells, albeit with no impact on T-cell polarization. Hence, pDCs can respond to bacteria but can be educated by epithelial cells to remain anergic to potential inflammatory signals. These findings support a mechanism by which intraepithelial pDCs, which are exposed to the microbiota colonizing the upper respiratory tract, remain capable of initiating immunity without overreacting to microbial stimulation.
New 3-[4-(3-substituted phenyl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propanol derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants. (2002)

In this paper a series of new 3-[4-(3-substituted phenyl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propanol derivatives is presented as a new class of antidepressant drugs with dual activity at 5-HT1A serotonin receptors and serotonin transporter. The 5-HT1A receptor and 5-HT transporter binding affinities of hydroxylic compounds 4 a-e have been determined. The new compounds present nanomolar affinity for both activities, and 1-(benzo[b]thiophen-3-yl)-3-[4-(3-methoxyphenyl)piperazin-1-yl]propan-1-ol (4d) shows values (nM) of Ki = 86 for 5-HT1A receptors and Ki = 76 for the serotonin transporter, respectively.
Smart SMART Bounds for Weighted Response Time Scheduling (1998)

Consider a system of independent tasks to be scheduled without preemption on a parallel computer. For each task the number of processors required, the execution time, and a weight are known. The problem is to find a schedule with minimum weighted average response time. We present an algorithm called SMART (which stands for scheduling to minimize average response time) for this problem that produces solutions that are within a factor of 8.53 of optimal. To our knowledge this is the first polynomial-time algorithm for the minimum weighted average response time problem that achieves a constant bound. In addition, for the unweighted case (that is, where all the weights are unity) we describe a variant of SMART that produces solutions that are within a factor of 8 of optimal, improving upon the best known bound of 32 for this special case.
The solution structure of full-length dodecameric MCM by SANS and molecular modeling (2014)

The solution structure of the full-length DNA helicase minichromosome maintenance protein from Methanothermobacter thermautotrophicus was determined by small-angle neutron scattering (SANS) data together with all-atom molecular modeling. The data were fit best with a dodecamer (dimer of hexamers). The 12 monomers were linked together by the B/C domains, and the adenosine triphosphatase (AAA+) catalytic regions were found to be freely movable in the full-length dodecamer both in the presence and absence of Mg(2+) and 50-meric single-stranded DNA (ssDNA). In particular, the SANS data and molecular modeling indicate that all 12 AAA+ domains in the dodecamer lie approximately the same distance from the axis of the molecule, but the positions of the helix-turn-helix region at the C-terminus of each monomer differ. In addition, the A domain at the N-terminus of each monomer is tucked up next to the AAA+ domain for all 12 monomers of the dodecamer. Finally, binding of ssDNA does not lock the AAA+ domains in any specific position, which leaves them with the flexibility to move both for helicase function and for binding along the ssDNA.
Polarization Filter Based on Linear Radon Transform to Extract Surface Waves in 3C Seismic Data (2022)

Summary Polarization filters can be used when multicomponent seismic data are available. These filters can separate surface waves and body waves by discriminating between elliptical versus linear particle motion. The most important advantage of the existing polarization filters is that they work in single-station. Therefore, they are an alternative when surface waves are aliased. However, in most cases, polarization filters do not get better results than f-k filters because they do not operate in multitrace, and there is no velocity discrimination. We present a new polarization filter to extract surface waves from multitrace 3C seismic data. The filter works in the frequency-slowness domain as a mask on elliptic elements obtained from the linear Radon model of the seismic data in the frequency domain. We applied this filter on a 3C real shot gather from land seismic data acquired in the Middle Magdalena Valley in Colombia. The result shows that this polarization filter can extract the surface waves accurately.
The Synthesis and Investigation of the Liquid-Crystalline Phase Behaviour of a Series of N,N-bis(1-deoxy-D-mannitol-1-yl)-alkamides (2001)

Abstract The results of our synthetic efforts and the investigation of the liquid-crystalline phase behaviour of a series of bis-mannosyl-amides are presented. In this investigation the structure of the polar carbohydrate groups was kept constant and the length of the terminal alkyl chain was varied between seven and twelve methylene groups. The results obtained from the DSC measurements, optical polarising microscopy and X-ray diffraction experiments will be reported and a structural model will be discussed.
Stress-induced polarization-graded ferroelectrics (2002)

Polarization-graded ferroelectrics and their electrically active embodiments, graded ferroelectric devices and transpacitors, have been formed from a variety of material systems, both by grading the composition of the ferroelectric and by imposing temperature gradients normal to the electrode surfaces. In this letter, we show how these same devices can be formed from homogeneous ferroelectric films of lead strontium titanate by imposing stress gradients on the material normal to their electrode surfaces.
Verbascoside Derivatives and Iridoid Glycosides fromVerbascum Undulatum (1998)

Abstract On further phytochemical investigation of the aerial parts of Verbascum undulatum, a new iridoid glycoside, 6-O-[3-O-(trans-feruloyl)-α-L-rhamnopyranosyl] aucubin (1) and a new verbascoside derivative, 6-O-acetyl-martynoside (2) were isolated. These structures were determined by spectral methods, mainly by 1D and 2D NMR spectroscopy.
Synthesizing distributed buffer clock trees for high performance ASICs (2002)

An integrated design system is presented in this paper for synthesizing high performance clock distribution networks for application to high speed ASICs. An optimal clock skew schedule is determined which provides a set of localized non-zero clock skew values that improve both circuit performance and reliability. These clock skew values together with the functional hierarchy are used to design the topology of the clock distribution network and to determine the minimum clock path delays which satisfy the clock skew schedule. Distributed buffers targeted for CMOS technology are synthesized to emulate the delay values assigned to the individual branches of the clock tree. Maximum errors of less than 2.5% for the delay of the clock paths and 4% for the clock skew between any two registers belonging to the same global data path as compared with SPICE Level-3 are demonstrated for an example circuit.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
HyperNeRF (2021)

Neural Radiance Fields (NeRF) are able to reconstruct scenes with unprecedented fidelity, and various recent works have extended NeRF to handle dynamic scenes. A common approach to reconstruct such non-rigid scenes is through the use of a learned deformation field mapping from coordinates in each input image into a canonical template coordinate space. However, these deformation-based approaches struggle to model changes in topology, as topological changes require a discontinuity in the deformation field, but these deformation fields are necessarily continuous. We address this limitation by lifting NeRFs into a higher dimensional space, and by representing the 5D radiance field corresponding to each individual input image as a slice through this "hyper-space". Our method is inspired by level set methods, which model the evolution of surfaces as slices through a higher dimensional surface. We evaluate our method on two tasks: (i) interpolating smoothly between "moments", i.e., configurations of the scene, seen in the input images while maintaining visual plausibility, and (ii) novel-view synthesis at fixed moments. We show that our method, which we dub HyperNeRF , outperforms existing methods on both tasks. Compared to Nerfies, HyperNeRF reduces average error rates by 4.1% for interpolation and 8.6% for novel-view synthesis, as measured by LPIPS. Additional videos, results, and visualizations are available at hypernerf.github.io.
Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor (2011)

Apixaban (BMS-562247; 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide), a direct inhibitor of activated factor X (FXa), is in development for the prevention and treatment of various thromboembolic diseases. With an inhibitory constant of 0.08 nM for human FXa, apixaban has greater than 30,000-fold selectivity for FXa over other human coagulation proteases. It produces a rapid onset of inhibition of FXa with association rate constant of 20 μM⁻¹/s approximately and inhibits free as well as prothrombinase- and clot-bound FXa activity in vitro. Apixaban also inhibits FXa from rabbits, rats and dogs, an activity which parallels its antithrombotic potency in these species. Although apixaban has no direct effects on platelet aggregation, it indirectly inhibits this process by reducing thrombin generation. Pre-clinical studies of apixaban in animal models have demonstrated dose-dependent antithrombotic efficacy at doses that preserved hemostasis. Apixaban improves pre-clinical antithrombotic activity, without excessive increases in bleeding times, when added on top of aspirin or aspirin plus clopidogrel at their clinically relevant doses. Apixaban has good bioavailability, low clearance and a small volume of distribution in animals and humans, and a low potential for drug-drug interactions. Elimination pathways for apixaban include renal excretion, metabolism and biliary/intestinal excretion. Although a sulfate conjugate of Ο-demethyl apixaban (O-demethyl apixaban sulfate) has been identified as the major circulating metabolite of apixaban in humans, it is inactive against human FXa. Together, these non-clinical findings have established the favorable pharmacological profile of apixaban, and support the potential use of apixaban in the clinic for the prevention and treatment of various thromboembolic diseases.
Introduction to the Special Issue on New Trends in Nanoelectronic Device, Circuit, and Architecture Design, Part 1 (2020)

introduction Share on Introduction to the Special Issue on New Trends in Nanoelectronic Device, Circuit, and Architecture Design, Part 1 Editors: Helen Li Duke University, Durham, NC Duke University, Durham, NCView Profile , Wei Zhang Hong Kong University of Science and Technology, Clear Water Bay, NT, Hong Kong SAR Hong Kong University of Science and Technology, Clear Water Bay, NT, Hong Kong SARView Profile , Swarup Bhunia University of Florida, Gainesville, FL University of Florida, Gainesville, FLView Profile , Wujie Wen Lehigh University, Bethlehem, PA Lehigh University, Bethlehem, PAView Profile Authors Info & Claims ACM Journal on Emerging Technologies in Computing SystemsVolume 16Issue 3July 2020 Article No.: 24pp 1–3https://doi.org/10.1145/3392080Published:27 June 2020Publication History 0citation105DownloadsMetricsTotal Citations0Total Downloads105Last 12 Months9Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access