gebhart/patrepeval huggingface dataset:
Localized Surface Plasmon Resonance Biosensors (2006)

In this review, the most recent progress in the development of noble metal nano-optical sensors based on localized surface plasmon resonance (LSPR) spectroscopy is summarized. The sensing principle relies on the LSPR spectral shifts caused by the surrounding dielectric environmental change in a binding event. Nanosphere lithography, an inexpensive and simple nanofabrication technique, has been used to fabricate the nanoparticles as the LSPR sensing platforms. As an example of the biosensing applications, the LSPR detection for a biomarker of Alzheimer's disease, amyloid-derived diffusable ligands, in human brain extract and cerebrospinal fluid samples is highlighted. Furthermore, the LSPR sensing method can be modified easily and used in a variety of applications. More specifically, a LSPR chip capable of multiplex sensing, a combined electrochemical and LSPR protocol and a fabrication method of solution-phase nanotriangles are presented here.
Blind peritoneal access during laparoscopy: why is it still being used? (2010)

Laparoscopy is an important diagnostic and therapeutic modality. It is one of the most commonly performed surgical procedures. Gaining access into the peritoneal cavity and insufflation is the first step in any laparoscopy. This should be the safest part of the procedure. We present a case in which closed induction of the pneumoperitoneum caused a near fatality that could have been avoided had an open technique been used. Endovascular therapy was used to prevent lethal complications of the patient's injuries. In the light of this case and the available literature on this topic, we question whether continued use of closed pneumoperitoneum induction for laparoscopy is still justified.
<title>Symmetry breaking and creation of second-order optical nonlinearity in polymer films by charge injection</title> (1995)

We review recent research showing how significant asymmetry and optical nonlinearity (second harmonic generation) can be produced by injection of electric charge into dye/polymer blends. The mechanism for producing the nonlinearity is different from the usual dipolar alignment of the dye in an electrostatic field. Charge injection has been achieved by purely electrical means using `in-plane' electrodes, or photochemically, by irradiating a bilayer structure comprising a photoconductive layer and the polymer/dye layer.
Secure multiparty privacy preserving data aggregation by modular arithmetic (2010)

The increasing ability to track and collect large amounts of data with the use of current hardware and software technology has lead to immense challenge and consequent interest in the development of data mining algorithms which preserve user security and privacy in a large distributed system. Secure data aggregation with privacy preserving feature is a demanding task. Privacy preservation is becoming a necessity for data generated for individual purpose as well as for organizational purpose. In this paper, we develop a scheme for secure multiparty data aggregation with the help of modular arithmetic concept. Specifically, we consider a scenario in which two or more parties owning confidential data need to share only for aggregation purpose to a third party, without revealing any unnecessary information. More generally, data aggregation needs to take place by the server or aggregator without acquiring the content of the individual data. Our work is motivated by the need to both protect privileged information and confidentiality. We have shown through simulation results the efficacy of our scheme and compare the result with one of the established scheme.
High-dose omeprazole infusion compared with scheduled second-look endoscopy for prevention of peptic ulcer rebleeding: a randomized controlled trial (2016)

ClinicalTrials.gov (NCT: 00164931).
Deep Learning to Evaluate Secure RSA Implementations (2019)

This paper presents the results of several successful profiled side-channel attacks against a secure implementation of the RSA algorithm. The implementation was running on a ARM Core SC 100 completed with a certified EAL4+ arithmetic co-processor. The analyses have been conducted by three experts’ teams, each working on a specific attack path and exploiting information extracted either from the electromagnetic emanation or from the power consumption. A particular attention is paid to the description of all the steps that are usually followed during a security evaluation by a laboratory, including the acquisitions and the observations preprocessing which are practical issues usually put aside in the literature. Remarkably, the profiling portability issue is also taken into account and different device samples are involved for the profiling and testing phases. Among other aspects, this paper shows the high potential of deep learning attacks against secure implementations of RSA and raises the need for dedicated countermeasures.
Doped Si nanoparticles with conformal carbon coating and cyclized-polyacrylonitrile network as high-capacity and high-rate lithium-ion battery anodes (2015)

Doped Si nanoparticles (SiNPs) with conformal carbon coating and cyclized-polyacrylonitrile (PAN) network displayed capacities of 3500 and 3000 mAh g(-1) at C/20 and C/10, respectively. At 1 C, the electrode preserves a specific discharge capacity of ∼1500 mAh g(-1) for at least 60 cycles without decay. Al2O3 atomic layer deposition (ALD) helps improve the initial Coulombic efficiency (CE) to 85%. The dual coating of conformal carbon and cyclized-PAN help alleviate volume change and facilitate charge transfer. Ultra-thin Al2O3 ALD layers help form a stable solid electrolyte interphase interface.
An OnLine Immunoassay for LSD: Comparison with GC-MS and the Abuscreen(R) RIA (1996)

A homogenous microparticle-based immunoassay has been developed for the detection of d-lysergic acid diethylamide (LSD) in human urine using the Online technology. This immunoassay is based on the principle of the kinetic interaction of microparticles in a solution where the drug content of the urine is directly proportional to the inhibition of the microparticle aggregation. Antibodies to LSD were obtained by immunizing goats with an LSD analogue derivatized through the indole nitrogen and conjugated to bovine thyroglobulin. The assay cutoff is 0.5 ng/mL LSD, and the clinical sensitivity for the detection of LSD and its metabolites in human urine samples is equivalent to the LSD Abuscreen RIA. Thirty-one samples previously screened LSD positive by Abuscreen RIA and confirmed by gas chromatography-mass spectrometry were analyzed by the Abuscreen OnLine LSD and Abuscreen LSD RIA assays. All thirty-one samples screened positive in the Abuscreen OnLine and Abuscreen RIA. OnLine's cross-reactivity to nor-LSD is greater than thirty-five percent; other structurally related compounds have similar cross-reactivity to that of the Abuscreen RIA. One thousand presumed negative urine samples were also analyzed; 992 (99.2%) of these gave negative results. The eight OnLine positive samples from this set were found to be negative by Abuscreen RIA. Typical qualitative within-run precision on the Hitachi 717 (at x = cutoff of 0.5 ng/mL; 0.5x, 1.0x, and 1.5x) was found to be less than 2.5%. Between-run precision was less than 3.0%.
Cell Interactions with Collagen MatricesIn VivoandIn VitroDepend on Phosphatidylinositol 3-Kinase and Free Cytoplasmic Calcium (1998)

We have investigated the role of phosphatidylinositol 3-kinase (PI3-kinase) in cellular interactions with collagenous matrices. Platelet-derived growth factor-BB (PDGF-BB) elicited a mobilization of intracellular Ca2+ in pig aortic endothelial (PAE) cells transfected with wild type PDGF beta-receptor. This response was greatly reduced in PAE cells transfected with PDGF beta-receptors mutated at positions Y740 and Y751 to prevent PI3-kinase binding. The experimental drug 1D-myo-inositol 1,2,6-trisphosphate (alpha-trinositol) induced a rapid increase and subsequent oscillations of the cytoplasmic Ca2+ concentration in cultured fibroblasts. This response was not due to an effect of alpha-trinositol on inositol 1,4,5-trisphosphate (IP3) receptors. alpha-Trinositol did not influence PDGF-BB elicited chemotaxis through collagen-coated membranes of PAE cells transfected with the wild-type PDGF beta-receptor, but restored PDGF-BB elicited chemotaxis of PAE cells transfected with the PI3-kinase binding-site mutated PDGF beta-receptor. Collagen gel contraction has been suggested to serve as a model for cellular control of interstitial fluid pressure (PIF) in dermis. The PI3-kinase inhibitors wortmannin (50 nM) and LY294002 (5 microM) inhibited the stimulation of fibroblast-mediated collagen gel contraction by 0.4 nM PDGF-BB. Injection of wortmannin in rat paw skin induced a lowering of PIF, and this effect was abolished in animals pre-treated with alpha-trinositol. Pretreatment of rats with alpha-trinositol abolished the decrease in PIF induced by injecting monoclonal anti-rat alpha 2 beta 1 integrin IgG in rat paw skin. Taken together our data indicate that cell-collagen interactions in vivo and in vitro depend on PI3-kinase, and that this dependence can be bypassed by a drug eliciting intracellular Ca2+ mobilization.
Kinetic Model of NOx SCR Using Urea on Commercial Cu−Zeolite Catalyst (2011)

Analysis of catalyst performance data over a commercial Cu−zeolite SCR catalyst shows that NH3 oxidation leads to NO formation at temperatures above 500 °C. This contributes to the reduction in NO conversion efficiency at high temperatures. It is shown that the conversion of NH3 to NO should be second order in NH3 concentration. A kinetic model incorporating this reaction is developed for a commercial SCR catalyst. The kinetic parameters are estimated using NO and NH3 conversion data collected over varying temperatures, flow rates, NH3 to NOx ratios, and NO2 to NOx ratios using actual engine exhaust. The optimized pre-exponential factors and activation energy are reported. The model is validated by comparing predictions with catalyst performance data over other engine operating conditions. The model predictions are in reasonable agreement with the measurements except at low temperatures and flow rates. The R2 value for NO conversion efficiency predictions is 0.88 and for NH3 slip is 0.76 excluding the predictions at low temperature and flow. Substoichiometric and superstoichiometric consumption of ammonia is observed while using urea for NOx SCR. It is proposed that lower ammonia consumption is due to direct reduction of NOx by unconverted urea or intermediates formed during urea to ammonia conversion. More than the stoichiometric amount of NH3 consumption at low temperature cannot be attributed to ammonia oxidation. The model shows that the predictions for this data can be significantly improved by allowing for incomplete conversion of urea to ammonia.
Hubert: How Much Can a Bad Teacher Benefit ASR Pre-Training? (2021)

Compared to vision and language applications, self-supervised pre-training approaches for ASR are challenged by three unique problems: (1) There are multiple sound units in each input utterance, (2) With audio-only pre-training, there is no lexicon of sound units, and (3) Sound units have variable lengths with no explicit segmentation. In this paper, we propose the Hidden-Unit BERT (HUBERT) model which utilizes a cheap k-means clustering step to provide aligned target labels for pre-training of a BERT model. A key ingredient of our approach is applying the predictive loss over the masked regions only. This allows the pre-training stage to benefit from the consistency of the unsupervised teacher rather that its intrinsic quality. Starting with a simple k-means teacher of 100 cluster, and using two iterations of clustering, the HUBERT model matches the state-of-the-art wav2vec 2.0 performance on the ultra low-resource Libri-light 10h, 1h, 10min supervised subsets.
Simultaneous multiple surface design method for diffractive surfaces (2016)

The simultaneous multiple surface (SMS) design method is extended to include design of diffractive optical surfaces besides refractive and reflective ones. This method involves the simultaneous and direct (no optimization) calculation of diffractive and refractive/reflective surfaces. Using the phase-shift properties of diffractive elements as an extra degree of freedom, two rays for each point on each diffractive surface are controlled. Representative diffractive systems designed by the SMS method are shown.
Long-term Chronological Changes in Very Asymmetric Keratoconus (2019)

On the basis of tomographic evaluation, even if the measured values are almost stable and within normal limits, a long-term clinical follow-up is warranted in forme fruste keratoconus eyes. Younger patients with very asymmetric keratoconus should be monitored carefully.
An unusual case of familial ALS and cerebellar ataxia (2010)

We report a case of familial amyotrophic lateral sclerosis (FALS) with clinical signs of cerebellar and posterior column involvement. The patient's work-up showed a known mutation (E100K) in the gene for Cu/Zn superoxide dismutase 1 (SOD1). Our case illustrates that extramotor symptoms, such as prominent cerebellar signs, can be seen in patients with FALS.
Erratum: “Effect of Y doping and composition-dependent elastic strain on the electrical properties of (Ba,Sr)TiO3 thin films deposited at 520°C” [Appl. Phys. Lett. 87, 192906 (2005)] (2007)

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Behavior in agricultural soils of a recombinant Pseudomonas bacterium that simultaneously degrades alkyl- and haloaromatics. (1992)

Pseudomonas sp. FR1 (pFRC20P) is a recombinant bacterium able simultaneously to degrade alkyl- and haloaromatics due to the xylXYZL and xylS genes from the TOL plasmid borne on the bacterial chromosome, and to the gene encoding for a gamma-lactone isomerase from Alcaligenes eutrophus on pFRC20P. The survival of this strain in sterile soils was shown to depend on the physicochemical properties of the soil. The recombinant information was stable in bacteria introduced in soils and conferred selective advantage to the host bacterium when the soils were amended with low amounts of p-methylbenzoate. However, relatively high amounts of this chemical significantly reduced survival of the bacterium. Survival was more seriously affected by chlorobenzoates than by methylbenzoates. Evolution of 14CO2 from p-methyl-14C-benzoate in soils confirmed that Pseudomonas sp. FR1 (pFRC20P) functions in a complex system in accordance with its design. Survival of Pseudomonas sp. FR1 (pFRC20P) was better at 4 degrees C and 25 degrees C than at 37 degrees C. On plates, the pFRC20P plasmid was mobilized by helper plasmids to P. putida at a frequency of about 10(-6) transconjugants per recipient. However, no transfer of recombinant DNA integrated on the chromosome was found, nor was lateral transfer of the recombinant DNA borne by Pseudomonas sp. FR1 (pFRC20P) detected in soils.
Identification and Targeting of Tyrosine Kinase Activity in Prostate Cancer Initiation, Progression, and Metastasis (2012)

Abstract : Current treatments for advanced prostate cancer are not very effective. To develop better treatment options, new approaches to investigate the signaling pathways important for advanced prostate cancer are warranted. Tyrosine kinase signaling contributes to numerous pathologies including cancer. In prostate cancer, mutation rates of tyrosine kinases are not readily observed, however, tyrosine phosphorylation of advanced prostate cancer is quite abundant indicating activity of tyrosine kinases are apparent even in the absence of activating mutations. Work supported by this award investigated this and found robust tyrosine phosphorylation in advanced prostate cancer in both human and mouse tumors. Using commonly perturbed non-tyrosine kinase oncogenes and pathways found in prostate cancer, phosphopeptide enrichment and quantitative mass spectrometry analysis revealed oncogene-specific tyrosine kinase signatures. Analysis of these signatures revealed unique tyrosine kinase signaling networks which may be targeted in advanced prostate cancer.
High-Isolation Resistorless Tunable Filtering Power Divider (2020)

This paper presents a novel architecture for a resistorless tunable filtering RF power divider with good isolation. The design is based on coupled dual-mode cavity resonators. At the even mode excitation, the primary resonance mode is coupled through the evanescent resonators, delivering the filtering response. The divided outputs are symmetrically coupled from the second resonator. During the odd excitation, the secondary mode emerges. The coupling in the presented power divider, however, is designed to prohibit the propagation of the secondary mode through the filter. Thus, the energy from the odd excitation is dissipated in the secondary mode resonance. As a result, the design requires no resistors. The presented power divider is designed, fabricated and measured. The varactor-tunable filtering power divider covers the frequency range of 2.15–2.45 GHz. The out-of-band isolation remains better than 13 dB. The 30-dB isolation bandwidth varies between 3.6%–5.2%.
Synthesis of Narrowly Size-Distributed Thermosensitive Poly(N-isopropylacrylamide) Nanocapsules in Inverse Miniemulsion (2010)

Narrowly size-distributed thermosensitive poly(N-isopropylacrylamide) (PNIPAM) nanocapsules with a hydrophilic core composed of an aqueous solution of cobalt tetrafluoroborate (CoTFB) were synthesized via a one-pot polymerization of N-isopropylacrylamide (NIPAM) and the cross-linking agent N,N′-methylene bis(acrylamide) (MBA) in inverse miniemulsion. CoTFB not only worked as template and lipophobe, but also promoted the dissolution of NIPAM in water by the formation of a complex between NIPAM and CoTFB. The formation of PNIPAM nanocapsules was verified by transmission electron microscopy (TEM) and atomic force microscopy (AFM). This is the first report to synthesize nanocapsules in inverse miniemulsion by following a phase separation mechanism as proposed by Tiarks et al. in direct miniemulsion [Tiarks, F.; Landfester, K.; Antonietti, M. Langmuir 2001, 17, 908−918]. The particle size distribution was narrowed by increasing the weight content of CoTFB, MBA, and water. The particle size of the nanocapsules could be conveniently tuned by varying the weight content of CoTFB and MBA. The as-prepared PNIPAM nanocapsules showed reversible thermosensitive properties. An ordered monolayer of PNIPAM nanocapsules could form by controlling the evaporation of apolar solvent, and moreover the size and thus interparticle distance of PNIPAM nanocapsules in the ordered arrays could be tuned by drying the sample under different temperatures below and above the lower critical solution temperature (LCST) of PNIPAM.
BCI‐838, an orally active mGluR2/3 antagonist pro‐drug, mimics the beneficial effects of physical exercise on neurogenesis, behavior and exercise‐related molecular pathways in an Alzheimer’s disease mouse model (2022)

Abstract Background Modulation of physical exercise (PE) represents an intervention that may delay, slow, or prevent mild cognitive impairment (MCI) or dementia due to Alzheimer’s disease (AD). One mechanism proposed to underlie beneficial effects of PE involves the apparent stimulation of adult hippocampal neurogenesis (AHNG). BCI‐838 is a pro‐drug whose metabolite BCI‐632 is one of the most active proneurogenic agents known and is an antagonist at group II metabotropic receptors (mGluR2/3). The drug stimulates AHNG while enhancing learning behavior and exerting anxiolytic and antidepressant properties. We previously demonstrated that the administration of BCI‐838 to a mouse model of cerebral and cerebrovascular accumulation of oligomeric Ab E22Q ( APP E693Q = “Dutch” ) reduced learning behavior impairment and anxiety, both of which are associated with the phenotype of Thy1.1‐ Dutch APP mice (Kim et al., Mol Psych 2014). Herein, we sought to determine whether BCI‐838 might substitute for PE, and/or whether treatment with a BCI‐838+PE combination might demonstrate synergistic effects in a mouse model of amyloidosis ( APP KM670/671NL /PSEN1 Δexon9 = APP/PS1 ). Method 3‐month‐old APP/PS1 mice were treated with either BCI‐838, PE (running wheels), or a combination of BCI‐838+PE for 1 month. We performed learning behavior tests (novel object recognition and Barnes maze), biochemical, and transcriptomic analyses on the hippocampal dentate gyrus (DG) of APP/PS1 mice. We performed gene set enrichment analysis, drug repurposing, and chemogenomic enrichment analyses to reveal molecular pathways of interest and investigated compounds with transcriptomically similar profiles as well as drug targets and side effects. Result We report that: (i) BCI‐838, PE, or BCI‐838+PE combination enhanced AHNG, (ii) BCI‐838 alone or associated with PE led to improvement in both spatial and recognition learning behaviors, (iii) BCI‐838 treatment increased mRNA levels of BDNF, metabotropic glutamate receptors, and PIK3C2A of the PI3K‐MTOR pathway, and decreased EIF5A of ketamine‐modulating mTOR activity in the hippocampal DG. qPCR results validated the statistical significance of the association between BCI‐838 treatment and increased levels of BDNF. Conclusion Our study points to BCI‐838 as a safe and orally active compound capable of mimicking the beneficial effect of exercise on AHNG, learning behavior, and anxiety in the APP/PS1 mouse model.
Supplementary Figure 2 from FcRL5 as a Target of Antibody–Drug Conjugates for the Treatment of Multiple Myeloma (2023)

&lt;p&gt;PDF file - 62KB, In vivo efficacy of anti-FcRL5-SPDB-DM4 in combination with bortezomib&lt;/p&gt;
Effects of Single vs. Multiple Sets of Weight Training (1997)

This study examined the effects of a single set of weight training exercise to failure and 2 multiple-set protocols (not to failure) on the 1-RM parallel squat. Forty-three men were randomly assigned to 1 of 3 weight training protocols emphasizing leg and hip strength: SS = single set to failure of 8–12 reps; MS = 3 × 10 reps; MSV = multiple-set program using a varied set and rep scheme. Relative intensity (% initial 1-RM), intensity (average mass lifted), and volume load (repetitions × mass) differed between groups over 14 weeks. Body mass, body composition, and the 1-RM parallel squat were assessed at baseline and at Weeks 5 and 14. Results showed no significant changes in body mass or body composition. The 1-RM squat increased significantly in all groups. Differences in 1-RM between groups indicate that MS and MSV increased approximately 50% more than SS over the 14 weeks. Results suggest that multiple sets not performed to failure produce superior gains in the 1-RM squat.
Validity Analysis of Holmium-Doped Fiber as Saturable Absorber for Passively Q-Switched Thulium-Doped Fiber Laser (2018)

We propose and demonstrate a method for measuring nonlinear transmission (NLT) of holmium-doped fiber (HDF) as saturable absorber (SA) by using two calibrated photodiodes. The HDF with a length of 10 cm is under test as reference, and the NLT measurement is carried out from 1930 to 1970 nm by using a tunable continuous-wave (CW) thulium-doped fiber laser (TDFL). The result finds that modulation depth of HDF is 56% at 1950 nm and decreases down to 37% at both 1930 and 1970 nm. Saturation power is about 20 mW for all measured wavelengths. The validity of the HDF SA for a passively Q-switched TDFL is also studied by taking the measured parameters into account. The laser operates in Q-switched mode from 1944 to 1960 nm, whereas in CW mode beyond the wavelength range due to insufficient modulation depth. The pulse temporal characteristics are also discussed.