gebhart/patrepeval huggingface dataset:
Lifespan extension of basal cell nevus syndrome fibroblasts by transfection with mouse pro or v‐myc genes (1987)

Dermal fibroblasts from patients with the autosomal dominant cancer-prone disease Basal Cell Nevus Syndrome (BCNS) exhibit a serum dependence, anchorage dependence and in vitro lifespan (about 20 population doublings or less) similar to those of fibroblasts from normal age-, race- and sex-matched controls. Transfection with v-myc or with an activated mouse pro-I gene (which specifies sensitivity to promotion of neoplastic transformation in JB6 mouse epidermal cells) specifically conferred partial immortality on the BCNS fibroblasts by substantially extending their population doubling levels by more than 19 population doublings. This suggests that either v-myc or pro-I gene can cooperate with BCNS gene(s) to produce an extension of lifespan or partial immortality. However, the transfected BCNS fibroblasts that escaped senescence were anchorage-dependent even after exposure to the tumor promoters 12-O-tetradecanoyl-phorbol-13-acetate (TPA), epidermal growth factor (EGF) or platelet-derived growth factor (PDGF). These observations indicate that BCNS fibroblasts differ from their normal counterparts in susceptibility to extended growth and may therefore be pre-neoplastic. It is clear that they require more than an activated pro or myc gene for progression to the tumor cell phenotype.
NeuroChat with Professor Catherine Abbott (2019)

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTNeuroChat with Professor Catherine AbbottCraig W. LindsleyCraig W. LindsleyMore by Craig W. Lindsleyhttp://orcid.org/0000-0003-0168-1445Cite this: ACS Chem. Neurosci. 2019, 10, 10, 4185–4186Publication Date (Web):October 16, 2019Publication History Published online16 October 2019Published inissue 16 October 2019https://pubs.acs.org/doi/10.1021/acschemneuro.9b00511https://doi.org/10.1021/acschemneuro.9b00511editorialACS PublicationsCopyright © 2019 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views558Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (2 MB) Get e-AlertscloseSUBJECTS:Diseases and disorders,Genetics,Molecular modeling,Optical properties Get e-Alerts
The neuraminidase and matrix genes of the 2009 pandemic influenza H1N1 virus cooperate functionally to facilitate efficient replication and transmissibility in pigs (2012)

The 2009 pandemic H1N1 virus (pH1N1) contains neuraminidase (NA) and matrix (M) genes from Eurasian avian-like swine influenza viruses (SIVs), with the remaining six genes from North American triple-reassortant SIVs. To characterize the role of the pH1N1 NA and M genes in pathogenesis and transmission, their impact was evaluated in the background of an H1N1 triple-reassortant (tr1930) SIV in which the HA (H3) and NA (N2) of influenza A/swine/Texas/4199-2/98 virus were replaced with those from the classical H1N1 A/swine/Iowa/15/30 (1930) virus. The laboratory-adapted 1930 virus did not shed nor transmit in pigs, but tr1930 was able to shed in infected pigs. The NA, M or both genes of the tr1930 virus were then substituted by those of pH1N1. The resulting virus with both NA and M from pH1N1 grew to significantly higher titre in cell cultures than the viruses with single NA or M from pH1N1. In a pig model, only the virus containing both NA and M from pH1N1 was transmitted to and infected sentinels, whereas the viruses with single NA or M from pH1N1 did not. These results demonstrate that the right combination of NA and M genes is critical for the replication and transmissibility of influenza viruses in pigs.
Three-wavelength-division-multiplexed multichannel subcarrier-multiplexing transmission over multimode fiber with potential capacity of 12 Gb/s (1999)

We investigate the feasibility of 10-Gb/s delivery over multimode-fiber (MMF) local area networks by using the externally modulated multiple-wavelength-division-multiplexed subcarrier-multiplexed technique. In a system experiment, three externally modulated distributed-feedback lasers with different wavelengths (1551.1, 1553.6, and 1556.1 nm) are used to carry a total of 300 random-phased continuous-wave carriers for simulating 300 channels of 256-QAM signals. The transport of a potential capacity of 12 Gb/s (=40 Mb/s/spl times/300 channels) over a 4-km MMF link is demonstrated and analyzed.
Evaluation of Natural Colorants and Their Application on Citrus Fruit as Alternatives to Citrus Red No. 2 (2015)

Warm field temperatures can often result in poor peel color of some citrus varieties, especially early in the harvest season. Under these conditions, Florida oranges, temples, tangelos, and K-Early citrus fruit are allowed to be treated with Citrus Red No.2 dye (CR2) to help produce a more acceptable peel color. Unfortunately, CR2, the commercial colorant used in Florida, has been listed as a group 2B carcinogen by the European Union (EU) and the International Agency for Research on Cancer (IARC). Although not likely dangerous at levels used on citrus, and on a part of the fruit that is not ingested, there is a negative health perception, and thus, a need for natural or food grade alternative colorants to replace CR2 for use on citrus. This research demonstrated that three out of five oil-soluble natural red/orange colorants resulted in peel colors somewhat similar to the industry standard CR2. These three (annatto extract, paprika extract, and paprika oleoresin) were selected for further in vivo studies. The stability of the natural colorants along with CR2 was evaluated by applying them on test papers and then on fresh ‘Hamlin’ oranges. All natural colorants were found to be easily oxidized and faded when applied on test papers. However, coating the colored surfaces with carnauba wax apparently inhibited oxidation and the subsequent discoloration of the surface. When applying the natural colorants to ‘Hamlin’ oranges before waxing, the treatments retained the improved color after storage in the dark at 5 °C, simulating cold storage. However, only annatto extract maintained a stable color when subsequently stored in a simulated market condition, at 23 °C exposed to 300 lx of standard fluorescent white light.
Einzelne Moleküle, Zellen und superhochauflösende Optik (Nobel‐Aufsatz) (2015)

Die Auflösung eines Mikroskops unterliegt in der klassischen Mikroskopie der Beugungsgrenze, wodurch man Objekte etwa im Abstand der halben Lichtwellenlänge nicht mehr getrennt wahrnehmen kann. Um unter die Beugungsgrenze zu gelangen, bedurfte es daher einiger Tricks und Erfindungen. E. Betzig schildert in seinem Nobel-Aufsatz die Entwicklungen, die zur modernen superhochauflösenden Mikroskopie führten.
CO dissociation characteristics on size-distributed rhodium islands on alumina model substrates (1998)

The dissociation of CO on size-distributed Rh particles supported on a thin alumina film has been studied with high resolution X-ray Photoelectron Spectroscopy (XPS) and X-ray Absorption Spectroscopy (XAS). Adsorbed CO dissociates upon heating to temperatures above 300 K. The dissociation activity is dependent on the island size, exhibiting a maximum for islands with around 1000 atoms. We have identified size-dependent changes in the C 1s photoelectron spectra for these CO–Rh systems occurring at temperatures lower than the onset of both the dissociation and desorption processes. These changes are interpreted as being due to adsorbed CO shifting into more highly coordinated sites. The dissociation activity is directly correlated to the availability of these sites, where the observed dissociation is proposed to occur. These results can be interpreted primarily in terms of the size and shape of the deposited Rh particles.
Polymerization of benzylthiocyanate on silver nanoparticles and the formation of polymer coated nanoparticles (2005)

Polymerization of benzylthiocyanate on silver nanoparticles produces organic shell covered nanoparticles with controllable thickness in a one-pot process. Gram scale quantities of core–shell materials have been synthesized by this method. The methodology involves the addition of the precursor into Ag–citrate solution and the shell nucleates over a period of three weeks with complete precipitation of the core–shell material which can be dispersed subsequently in organic solvents. The material has been characterized using transmission electron microscopy, X-ray diffraction, FT-IR, laser desorption mass spectrometry, thermogravimetry, surface enhanced resonance Raman spectroscopy (SERRS) and Raman imaging. A typical composite material consists of a silver core of 40 nm diameter coated with a polymeric shell of 8 nm thickness. The polymer exhibits characteristic features in mass spectrometry and vibrational spectroscopy. The core–shell structure of nanoparticles is imaged for the first time using the Raman intensity of the shell. Proton assisted polymerization of benzylthiocyanate occurs on the silver surface, leading to a linear chain which subsequently deposits on the nanoparticle surface resulting in the core–shell structure.
Balance functions fromAu+Au,d+Au, andp+pcollisions atsNN=200GeV (2010)

PHYSICAL REVIEW C 82
Supplementary Table 1 from Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors (2023)

&lt;p&gt;PDF file - 74K, Table describing clinical and molecular characteristics of NSCLC patients&lt;/p&gt;
Determination at 300K of the hole capture cross section of chromium-boron pairs in p-type silicon (2006)

Measurement of dissolved chromium concentration in p-type crystalline silicon by means of the change in carrier lifetime due to chromium-boron pair dissociation requires precise knowledge of the recombination parameters of dissolved chromium in silicon. This work, based on quasi-steady-state carrier lifetime measurements, aims to determine the value at 300K of the hole capture cross section of the chromium-boron pairs in p-type silicon, which is the only recombination parameter still unknown at this temperature. The complete knowledge of the recombination parameters allows the determination of dissolved chromium concentrations in p-type silicon as low as 1010cm−3, even when chromium atoms do not dominate carrier recombination.
Multinanometer wavelength conversion of 2.5 and 10 Gb/s optical channels in an injection-locked semiconductor laser (1994)

We have demonstrated multinanometer wavelength conversion of amplitude-shift-keyed 1.5 μm-optical signals, using cavity-enhanced four-wave mixing in an injection-locked semiconductor laser. 2.5-Gb/s operation was possible with injected signal powers as low as -29.3 dBm, due to the resonant gain of the mixing laser. We have also reported 10-Gb/s operation, the highest data rate at which this method has been demonstrated.
Application of P,N-Sulfinyl Imine Ligands to Iridium-Catalyzed Asymmetric Hydrogenation of Olefins (2004)

The utility of a novel class of P,N-ligands incorporating a chiral sulfinyl imine moiety is demonstrated in the iridium-catalyzed hydrogenation of both functionalized and unfunctionalized olefins, in which enantioselectivities of up to 94% are achieved. The modularity of the P,N-sulfinyl ligand class is highlighted by the facile preparation of a variety of sterically and electronically different ligands. Interesting structure-activity data for both the phosphine and sulfinamide components is provided by this expanded ligand set.
Concomitant Imbalances of Systemic and Mucosal Immunity Increase HIV Acquisition Risk (2020)

Changes in both peripheral and mucosal immunity may precede and predispose women to HIV infection. Suppressed systemic immunity (ie, low CRP) alone or in combination with imbalanced cervical innate immunity (high proinflammatory and low anti-inflammatory mediators) indicated increased vulnerability to infection. Understanding these combined effects on HIV susceptibility is essential to preventing new infections.
Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations (2017)

Lipin-1 is a Mg<sup>2+</sup>-dependent phosphatidic acid phosphatase (PAP) that in mice is necessary for normal glycerolipid biosynthesis, controlling adipocyte metabolism, and adipogenic differentiation. Mice carrying inactivating mutations in the <i>Lpin1</i> gene display the characteristic features of human familial lipodystrophy. Very little is known about the roles of lipin-1 in human adipocyte physiology. Apparently, fat distribution and weight is normal in humans carrying <i>LPIN1</i> inactivating mutations, but a detailed analysis of adipose tissue appearance and functions in these patients has not been available so far. In this study, we performed a systematic histopathological, biochemical, and gene expression analysis of adipose tissue biopsies from human patients harboring <i>LPIN1</i> biallelic inactivating mutations and affected by recurrent episodes of severe rhabdomyolysis. We also explored the adipogenic differentiation potential of human mesenchymal cell populations derived from lipin-1 defective patients. White adipose tissue from human <i>LPIN1</i> mutant patients displayed a dramatic decrease in lipin-1 protein levels and PAP activity, with a concomitant moderate reduction of adipocyte size. Nevertheless, the adipose tissue develops without obvious histological signs of lipodystrophy and with normal qualitative composition of storage lipids. The increased expression of key adipogenic determinants such as <i>SREBP1</i>, <i>PPARG</i>, and <i>PGC1A</i> shows that specific compensatory phenomena can be activated in vivo in human adipocytes with deficiency of functional lipin-1.
The Effect of Oral Local Anaesthetic and Alkali on Basal and Food-stimulated Serum Gastrin Levels in Patients with Duodenal Ulcer (1978)

Twelve patients with duodenal ulcers were each given on separate days and in random order an oral local anaesthetic (oxethazaine), an alkali (aluminium hydroxide and magnesium hydroxide), a combination of local anaesthetic and alkali (Mucaine), and a similar volume of water (control) followed one hour later by a solution of meat extract (Oxo). The effect of these treatments on serum gastrin levels was measured. None of the treatments altered the normal basal gastrin levels. The gastrin response to ingestion of protein extract was significantly lower in patients who had been pre-treated with local anaesthetic than those who had received alkali, with or without local anaesthetic, or water.
Measurement of Directionally Resolved Radar Cross Section of Human Body for 140 and 220 GHz Bands (2020)

To explore the eventual deployment of communication systems in Terahertz (THz) band (0.1-10 THz) frequencies, extensive measurements of various aspects of the channels are essential. Humans form an integral part of any communication environment, therefore, it is of interest to explore the impact of a human body on the propagation characteristics in any given channel. This is particularly relevant because at higher frequencies, such as those in the THz band, human bodies are significantly larger than a wavelength and can thus constitute effective scatterers. Motivated by this, we conducted measurements of the radar cross section for the human body in the 140 and 220 GHz bands and show how the reflectivity of the human body varies as a function of both the angle of incidence and the angle of observation. Our results show an average scattering cross sections on the order of -15 dBsm for the 220 GHz band and -23 dBsm for the 140 GHz band; with variations as a function of the angle of incidence to be less than +/- 2 dBsm for both cases.
Factor V Leiden: should we screen oral contraceptive users and pregnant women? (1996)

The factor V Leiden mutation is the most common genetic risk factor for deep vein thrombosis: it is present in about 5% of the white population. The risk of deep vein thrombosis among women who use oral contraceptives is greatly increased by the presence of the mutation. The same seems to be true of the risk of postpartum thrombosis. Several authors have called for all women to be screened before prescription of oral contraceptives and during pregnancy. Such a policy might deny effective contraception to a substantial number of women while preventing only a small number of deaths due to pulmonary emboli. Moreover, in pregnancy the ensuing use of oral anticoagulation prophylaxis might carry a penalty of fatal bleeding that is equal to or exceeds the risk of death due to postpartum thrombosis. It might pay, however, to take a personal and family history of deep vein thrombosis when prescribing oral contraceptives or at a first antenatal visit to detect women from families with a tendency to multiple thrombosis.
Statistical Analyses of Inverse Miniemulsion Acrylic Acid Polymerizations for Encapsulation of Hydrophilic Compounds (2019)

Polymer hydrogel nanoparticles are produced through inverse miniemulsion polymerizations, using acrylic acid as monomer and soybean oil as the continuous phase. A crosslinking agent is used to promote the reticulation of the polymer chains and production of hydrophilic nanogels. The synthesis of the polymer nanoparticles is studied with aid of a full factorial design using monomer content, crosslinker content, and reaction temperature as independent variables and monomer conversion and thermal stability of the obtained material as the main responses. The potential to encapsulate hydrophilic actives into the hydrogel matrix is evaluated by using a commercial blue dye as a model. It is observed that incorporation of the blue dye is efficient and that the rates of dye release are very low at different pH values, suggesting the existence of strong physicochemical interactions with the polymer matrix, which can be advantageous in bioimaging and paint applications. Particularly, the proposed inverse miniemulsion procedure enabled the production of stable nanogels.
Multisite Solid Catalyst for Cascade Reactions: The Direct Synthesis of Benzodiazepines from Nitro Compounds (2009)

Substituted 1,5-benzodiazepines are selectively synthesized in one pot from substituted nitroaromatics and ketones. The reaction is performed in the presence of hydrogen and in the absence of solvent by using a bifunctional solid catalyst with a chemoselective hydrogenation functional group capable of reducing the nitro group to a diamino group and an acid functional group, which catalyzes the cyclocondensation of the amino group with the ketone.
Doppler‐Derived Renal Venous Stasis Index in the Prognosis of Right Heart Failure (2019)

Background Persistent congestion with deteriorating renal function is an important cause of adverse outcomes in heart failure. We aimed to characterize new approaches to evaluate renal congestion using Doppler ultrasonography. Methods and Results We enrolled 205 patients with suspected or prediagnosed pulmonary hypertension (PH) undergoing right heart catheterization. Patients underwent renal Doppler ultrasonography and assessment of invasive cardiopulmonary hemodynamics, echocardiography, renal function, intra-abdominal pressure, and neurohormones and hydration status. Four spectral Doppler intrarenal venous flow patterns and a novel renal venous stasis index (RVSI) were defined. We evaluated PH-related morbidity using the Cox proportional hazards model for the composite end point of PH progression (hospitalization for worsening PH, lung transplantation, or PH-specific therapy escalation) and all-cause mortality for 1-year after discharge. The prognostic utility of RVSI and intrarenal venous flow patterns was compared using receiver operating characteristic curves. RVSI increased in a graded fashion across increasing severity of intrarenal venous flow patterns (<i>P</i><0.0001) and was significantly associated with right heart and renal function, intra-abdominal pressure, and neurohormonal and hydration status. During follow-up, the morbidity/mortality end point occurred in 91 patients and was independently predicted by RVSI (RVSI in the third tertile versus referent: hazard ratio: 4.72 [95% CI, 2.10-10.59; <i>P</i><0.0001]). Receiver operating characteristic curves suggested superiority of RVSI to individual intrarenal venous flow patterns in predicting outcome (areas under the curve: 0.789 and 0.761, respectively; <i>P</i>=0.038). Conclusions We propose RVSI as a conceptually new and integrative Doppler index of renal congestion. RVSI provides additional prognostic information to stratify PH for the propensity to develop right heart failure. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT03039959.
Inside 6th gen Intel® Core™: New microarchitecture code named skylake (2016)

The Intel core microarchitecture is a new foundation for Intel architecture-based desktop, mobile and mainstream server multi-core processors. Designed for efficiency and optimised performance across a range of market segments and power envelopes.
Hierarchical Nanoparticle Bragg Mirrors: Tandem and Gradient Architectures (2011)

Abstract To manipulate electrons in semiconductor electronic and optical devices, the usual approach is through materials composition, electronic bandgap, doping, and interface engineering. More advanced strategies for handling electrons in semiconductor devices include composition‐controlled heterostructures and gradient structures. By analogy to the manipulation of electrons in semiconductor crystals by electronic bandgaps, photons in photonic crystals can be managed using photonic bandgaps. In this context, the simplest photonic crystal is the Bragg mirror, a periodic dielectric construct whose photonic bandgap is engineered through variations of the optical thickness of its constituent layers. Traditionally the materials comprising these periodic dielectric layers are nonporous, and they have mainly been used in the field of optical and photonic devices. More recently these Bragg mirrors have been made porous by building the layers from nanoparticles with functionality and utility that exploit their internal voids. These structures are emerging in the area of photonic color‐coded chemical sensing and controlled chemical release. Herein, a strategy for enhancing the functionality and potential utility of nanoparticle Bragg mirrors by making the constituent dielectric layers aperiodic and porous is described. It is exemplified by prototypical tandem and gradient structures that are fully characterized with regards to their structure, porosity, and optical and photonic properties.
Régulation et Rôle de CmpX chez Pseudomonas aeruginosa (2018)

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