gebhart/patrepeval huggingface dataset:
A NEW MEMBER OF THE GROWTH-PROMOTING GLYCOPROTEINS FROM DIAPREPES ROOT WEEVIL (COLEOPTERA: CURCULIONIDAE) (2006)

A new member belonging to the family of growth-promoting glycoproteins referred to as imaginal disc growth factors, IDGF, was identified from the root weevil Diaprepes abbreviatus (L.), (Coleoptera: Curculionidae). The imaginal disc growth factor full length cDNA transcript, designated as idgf-DRW, was cloned and identified from tissue of adult, teneral DRW females. Sequencing and subsequent homology comparisons of the nucleotide sequence (GenBank accession no. AY821658) indicated that the open reading frame (ORF) consisted of 1329 bases and encoded a putative protein of 442 amino acid residues with a calculated molecular weight of 49.5 kDa and a pI value of 6.68. BLASTX comparisons of the idgf-DRW cDNA sequence showed that the deduced amino acid sequence designated as IDGF-DRW (AAV68692.1) had 43% to 51% similarity with IDGF1-5 and DS47 from Drosophila melanogaster, D. simulans, and D. yakuba, 51% similarity with IDGF in Pieris rapae, and 51% similarity with an IDGF-like protein in Bombyx mori. Signal P analysis revealed that the predicted IDGF-DRW contained a signal peptide of 23 amino acid residues located at the N-terminus, similar to other known IDGF proteins. The structure of IDGF-DRW was predicted based on the characterized IDGF2 from D. melanogaster as the model. The deduced amino acid sequence for the IDGF-DRW protein had 48% similarity with Drosophila melanogaster IDGF2. The predicted IDGF-DRW displays the characteristics found in Drosophila IDGFs, the fold of family 18 glycosyl hydrolases, with an insertion (Gly304 to Phe392) in the beta barrel between strand β7 and helix alpha-7 that forms an additional α β domain similar to that of Serratia marcescens chitinases A and B. An identified nucleotide change which results in an amino acid change within the active binding site in IDGF-DRW also was observed. The significant similarities of IDGF-DRW to other members within the family of IDGFs support its classification as a new member of the invertebrate growth factors and the first IDGF to be identified from a coleopteran.Abbreviations: EST, expressed sequence tag; DS47, chitinase-like protein precursor; CHIT, chitinase; IDGF, imaginal disc growth factor protein; DRW, diaprepes root weevil; idgf, imaginal disc growth factor transcript.
Syndiospecific living polymerization of 4‐methylstyrene and styrene with (trimethyl)pentamethylcyclopentadienyltitanium/tris(pentafluorophenyl)borane/trioctylaluminum catalytic system (2001)

Abstract The polymerizations of styrene and 4‐methylstyrene (4MS) with a half‐metallocene type catalytic system composed of (trimethyl)pentamethylcyclopentadienyltitanium (Cp*TiMe 3 ), trioctylaluminum (AlOct 3 ), and tris(pentafluorophenyl)borane [B(C 6 F 5 ) 3 ] were investigated at −25 °C. The addition of AlOct 3 as a third component of the catalytic system is effective both to promote the syndiospecific polymerization and to inhibit the nonstereospecific polymerization at the low‐temperature region. The use of AlOct 3 was also effective to eliminate the chain transfer reaction to alkylaluminum. The number‐average molecular weights ( M n 's) of poly(4MS) or polystyrene increased proportionally with increasing monomer conversion. The molecular weight distribution (MWD) of polymer stayed narrow [ M w / M n = ∼ 1.1 for poly(4MS) and M w / M n = ∼ 1.5 for polystyrene]. It was thus concluded that the polymerizations of the styrenic monomers with Cp*TiMe 3 /B(C 6 F 5 ) 3 /AlOct 3 catalytic system proceeded under living fashion at −25 °C. The living random copolymerization behaviors of styrene and 4MS were also confirmed. The 13 C NMR analysis clarified that each of the homopolymers and random copolymers obtained in this work had highly syndiotactic structure. © 2001 John Wiley &amp; Sons, Inc. J Polym Sci Part A: Polym Chem 39: 3692–3706, 2001
Design, Implementation, and Characterization of a Cooperative Communications System (2011)

Cooperative communications is a class of techniques that seek to improve reliability and throughput in wireless systems by pooling the resources of distributed nodes. Although cooperation can occur at different network layers and time scales, physical-layer cooperation at symbol time scales offers the largest benefit in combating losses due to fading. However, symbol-level cooperation poses significant implementation challenges, particularly in synchronizing the behavior and carrier frequency of distributed nodes. We present the implementation and characterization of a complete real-time cooperative physical-layer transceiver built on the Rice University Wireless Open-Access Research Platform (WARP). In our implementation, autonomous nodes employ physical-layer cooperation without a central synchronization source and can select between non-cooperative and cooperative communications per packet. Cooperative transmissions use a distributed Alamouti space-time block code (STBC) and employ either amplify-and-forward (AF) or decode-and-forward (DF) relaying. We also present experimental results of our transceiver's real-time performance under various topologies and propagation conditions. Our results clearly demonstrate significant performance gains (more than 40× improvement in packet error rate in some topologies) provided by physical-layer cooperation, even when subject to the constraints of a real-time implementation. Finally, we present methodologies for isolating and understanding the sources of performance bottlenecks in our design. As with all our work on WARP, our transceiver design and experimental framework are available through the open-source WARP repository for use by other wireless researchers.
ChemInform Abstract: Synthesis and Antiviral Evaluation of β‐L‐Xylo‐furanosyl Nucleosides of the Five Naturally Occurring Nucleic Acid Bases. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Conservatively Managed Fetal Goiter: An Alternative to in utero Therapy (2013)

Fetal goiter may arise from a variety of etiologies including iodine deficiency, overtreatment of maternal Graves' disease, inappropriate maternal thyroid replacement and, rarely, congenital hypothyroidism. Fetal goiter is often associated with a retroflexed neck and polyhydramnios, raising concerns regarding airway obstruction in such cases. Prior reports have advocated for cordocentesis and intra-amniotic thyroid hormone therapy in order to confirm the diagnosis of fetal thyroid dysfunction, reduce the size of the fetal goiter, reduce polyhydramnios, aid with the assistance of maternal thyroid hormone therapy and reduce fetal malpresentation. We report two cases of conservatively managed fetal goiter, one resulting in a vaginal delivery, and no evidence of postnatal respiratory distress despite the presence of polyhydramnios and a retroflexed neck on prenatal ultrasound.
Fluctuating Thermal Field in the Near Hole Region for Film Cooling Flows (1996)

The film cooling flow field is the result of a highly complex interaction between the film cooling jets and the mainstream, Understanding this interaction is important in order to explain the physical mechanisms involved in the rapid decrease of effectiveness which occurs close to the hole exit. Not surprisingly, it is this region which is not modeled satisfactorily with current film cooling models. This study uses a high frequency response temperature sensor which provides new information about the film cooling flow in terms of actual turbulence levels and probability density functions of the thermal field. Mean and rms temperature results are presented for 35° round holes at a momentum flux ratio of I = 0.16, at a density ratio of DR = 1.05. Probability density functions of the temperature indicate penetration of the mainstream into the coolant core, and ejection of coolant into the mainstream. Extreme excursions in the fluctuating temperature measurements suggests existence of strong intermittent flow structures responsible for dilution and dispersion of the coolant jets.
Automated question generation for quality control in human computation tasks (2016)

When running large human computation tasks in the real-world, honeypots play an important role for assessing the overall quality of the work produced. The generation of such honeypots can be a significant burden on the task owner as they require specific characteristics in their design and implementation and continuous maintenance when operating data pipelines that include a human computation component. In this extended abstract we outline a novel approach for creating honeypots using automatically generated questions from a reference knowledge base with the ability to control such parameters as topic and difficulty.
Facile Synthesis of 3-Alkylpyrroles (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTFacile Synthesis of 3-AlkylpyrrolesAlexander Zelikin, Venkatram R. Shastri, and Robert LangerView Author Information Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 01239 Cite this: J. Org. Chem. 1999, 64, 9, 3379–3380Publication Date (Web):April 16, 1999Publication History Received25 November 1998Published online16 April 1999Published inissue 1 April 1999https://pubs.acs.org/doi/10.1021/jo9823339https://doi.org/10.1021/jo9823339brief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1361Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alkyls,Anions,Ketones,Pyrroles,Transfer reactions Get e-Alerts
Application of High Performance Computing for Simulating Cycle-to-Cycle Variation in Dual-Fuel Combustion Engines (2016)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Interest in operational cost reduction is driving engine manufacturers to consider low-cost fuel substitution in heavy-duty diesel engines. These dual-fuel (DF) engines could be operated either in diesel-only mode or operated with premixed natural gas (NG) ignited by a pilot flame of compression-ignited direct-injected diesel fuel. Under certain conditions, dual-fuel operation can result in increased cycle-to-cycle variability (CCV) during combustion. CFD can greatly help in understanding and identifying critical parameters influencing CCV. Innovative modelling techniques and large computing resources are needed to investigate the factors affecting CCV in dual-fuel engines. This paper discusses the use of the High Performance Computing resource Titan, at Oak Ridge National Laboratory, to investigate CCV of a dual-fuel engine. The CONVERGE CFD software was used to simulate multiple, parallel single cycles of dual-fuel combustion with perturbed operating parameters and boundary conditions. Perturbations associated with a single parameter can be studied using samples distributed according to a one dimensional interpolation rule. However, extending such techniques to a multidimensional context is a challenge since the straight forward &lt;u&gt;tensorization&lt;/u&gt; leads to an exponential growth of the required number of samples. In contrast, sparse grids are constructed from a linear combination of tensors with varying degree in each dimension where the tensors are chosen in a way that leads to a stable surface fitting algorithm of arbitrary order of accuracy with minimal number of samples. This technique is expected to be useful to understand and predict combustion stability limits in dual fuel combustion.&lt;/div&gt;&lt;/div&gt;
Optical fiber Fabry-Pérot sensor fabrication based on focused ion beam post-processing (2014)

A combination of focused ion beam milling and chemical etching is proposed for the creation of Fabry-Pérot cavities in microwires. Both simple cavities and cantilevers are created on 15 μm-diameter microwires and characterized in temperature. The cantilever structure shows sensitivity to vibration and is capable of measuring frequencies in the range 1 Hz – 40 kHz.
Partial Protection of Simian Immunodeficiency Virus (SIV)-Infected Rhesus Monkeys against Superinfection with a Heterologous SIV Isolate (2009)

Although there is increasing evidence that individuals already infected with human immunodeficiency virus type 1 (HIV-1) can be infected with a heterologous strain of the virus, the extent of protection against superinfection conferred by the first infection and the biologic consequences of superinfection are not well understood. We explored these questions in the simian immunodeficiency virus (SIV)/rhesus monkey model of HIV-1/AIDS. We infected cohorts of rhesus monkeys with either SIVmac251 or SIVsmE660 and then exposed animals to the reciprocal virus through intrarectal inoculations. Employing a quantitative real-time PCR assay, we determined the replication kinetics of the two strains of virus for 20 weeks. We found that primary infection with a replication-competent virus did not protect against acquisition of infection by a heterologous virus but did confer relative control of the superinfecting virus. In animals that became superinfected, there was a reduction in peak replication and rapid control of the second virus. The relative susceptibility to superinfection was not correlated with CD4(+) T-cell count, CD4(+) memory T-cell subsets, cytokine production by virus-specific CD8(+) or CD4(+) cells, or neutralizing antibodies at the time of exposure to the second virus. Although there were transient increases in viral loads of the primary virus and a modest decline in CD4(+) T-cell counts after superinfection, there was no evidence of disease acceleration. These findings indicate that an immunodeficiency virus infection confers partial protection against a second immunodeficiency virus infection, but this protection may be mediated by mechanisms other than classical adaptive immune responses.
Nonlinear optical characteristics of novel inorganic chromophores using the Zindo formalism (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNonlinear optical characteristics of novel inorganic chromophores using the Zindo formalismDavid R. Kanis, Mark A. Ratner, Tobin J. Marks, and Michael C. ZernerCite this: Chem. Mater. 1991, 3, 1, 19–22Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/cm00013a009https://doi.org/10.1021/cm00013a009research-articleACS PublicationsRequest reuse permissionsArticle Views190Altmetric-Citations84LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Bcl‐2 as a Therapeutic Target in Human Tubulointerstitial Inflammation (2016)

These data demonstrate that Bcl-2 is an attractive therapeutic target in patients with lupus nephritis who manifest TII.
RGB-NIR color image fusion: metric and psychophysical experiments (2015)

In this paper, we compare four methods of fusing visible RGB and near-infrared (NIR) images to produce a color output image, using a psychophysical experiment and image fusion quality metrics. The results of the psychophysical experiment show that two methods are significantly preferred to the original RGB image, and therefore RGB-NIR image fusion may be useful for photographic enhancement in those cases. The Spectral Edge method is the most preferred method, followed by the dehazing method of Schaul et al. We then investigate image fusion metrics which give results correlated with the psychophysical experiment results. We extend several existing metrics from 2 to 1 to <i>M</i> to <i>N</i> channel image fusion, as well as introducing new metrics based on output image colorfulness and contrast, and test them on our experimental data. While none of the individual metrics gives a ranking of the algorithms which exactly matches that of the psychophysical experiment, through a combination of two metrics we accurately rank the two leading fusion methods.
A new polymorphic probe on chromosome 3p: λLIB43–55′ (D3S728) (1991)

XLIB43 -55' is a 7.0 kb EcoRI fragment isolated from a Charon 21A human chromosome 3 library (1). Polymorphism: MspI digestion of genomic DNA and hybridization with the probe detects a two allele polymorphism: 7.6 kb (A1) and 4.5 kb (A2). Frequency: Estimated from 120 unrelated Caucasians.
Interaction of Murine MHC Class I Molecules with Tapasin and TAP Enhances Peptide Loading and Involves the Heavy Chain α3 Domain (1999)

Abstract In human cells the association of MHC class I molecules with TAP is thought to be mediated by a third protein termed tapasin. We now show that tapasin is present in murine TAP-class I complexes as well. Furthermore, we demonstrate that a mutant H-2Dd molecule that does not interact with TAP due to a Glu to Lys mutation at residue 222 of the H chain (Dd(E222K)) also fails to bind to tapasin. This finding supports the view that tapasin bridges the association between class I and TAP and implicates residue 222 as a site of contact with tapasin. The inability of Dd(E222K) to interact with tapasin and TAP results in impaired peptide loading within the endoplasmic reticulum. However, significant acquisition of peptides can still be detected as assessed by the decay kinetics of cell surface Dd(E222K) molecules and by the finding that prolonged viral infection accumulates sufficient target structures to stimulate T cells at 50% the level observed with wild-type Dd. Thus, although interaction with tapasin and TAP enhances peptide loading, it is not essential. Finally, a cohort of Dd(E222K) molecules decays more rapidly on the cell surface compared with wild-type Dd molecules but much more slowly than peptide-deficient molecules. This suggests that some of the peptides obtained in the absence of an interaction with tapasin and TAP are suboptimal, suggesting a peptide-editing function for tapasin/TAP in addition to their role in enhancing peptide loading.
Reference governors and maximal output admissible sets for linear periodic systems (2019)

In this paper, we consider the problem of constraint management in Linear Periodic (LP) systems using Reference Governors (RG). First, we introduce the periodic-invariant maximal output admissible sets for LP systems. We extend the earlier results in the literature to Lyapunov stable LP systems with output constraints, which arise in RG applications. We show that, while the invariant sets for these systems may not be finitely determined, a finitely-determined inner approximation, which is periodically invariant, can be obtained by constraint tightening. We then analyze the geometric and algebraic relationship between these sets and show that these sets are related via simple transformations, implying that it suffices to compute only one of them for real-time applications. This greatly reduces the memory burden of RG (or other similar constraint management strategies), at the expense of an increase in processing requirements. We present a thorough analysis of this trade-off. In the second part of this paper, we present two RG formulations, and discuss their properties and algorithms for their computation. Numerical simulations demonstrate the efficacy of the approach.