gebhart/patrepeval huggingface dataset:
Plasma biomarkers for diagnosis of Alzheimer’s disease and prediction of cognitive decline in individuals with mild cognitive impairment (2022)

ABSTRACT Background The last few years have seen major advances in blood biomarkers for Alzheimer’s Disease (AD) with the development of ultrasensitive immunoassays, promising to transform how we diagnose, prognose, and track progression of neurodegenerative dementias. Methods We evaluated a panel of four novel ultrasensitive electrochemiluminescence (ECL) immunoassays against presumed CNS derived proteins of interest in AD in plasma [phosphorylated-Tau181 (pTau181), total Tau (tTau), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP)]. 366 plasma samples from the Massachusetts Alzheimer’s Disease Research Center’s longitudinal cohort study were examined to differentiate definite AD, other neurodegenerative diseases (OND), and cognitively normal (CN) individuals. A subset of samples were selected to have longitudinal follow up to also determine the utility of this plasma biomarker panel in predicting 4-year risk for cognitive decline in individuals with different levels of cognitive impairment. Results pTau181, tTau and GFAP were higher in AD compared to CN and OND, while NfL was elevated in AD and further increased in OND. pTau181 performed the best (AD vs CN: AUC=0.88, 2-fold increase; AD vs OND: AUC=0.78, 1.5-fold increase) but tTau also showed excellent discrimination (AD vs CN: AUC=0.79, 1.5-fold increase; AD vs OND: AUC=0.72, 1.3-fold increase). Participants with MCI who progressed to AD dementia had higher baseline plasma concentrations of pTau181, NfL, and GFAP compared to non-progressors with the best discrimination for pTau181 (AUC=0.82, 1.7-fold increase) and GFAP (AUC=0.81, 1.6-fold increase). Conclusions These new ultrasensitive ECL plasma assays for pTau181, tTau, NfL, and GFAP detect CNS disease with high specificity and accuracy. Moreover, the absolute baseline plasma levels of pTau and GFAP reflect clinical disease aggressiveness over the next 4 years, providing diagnostic and prognostic information that may have utility in both clinical and clinical trial populations. Classification of Evidence This study provides Class II evidence that plasma levels of pTau181, tTau, NfL, and GFAP are associated with AD and that pTau181 and GFAP are associated with progression from MCI to AD dementia.
20 W Peak single-Transverse-mode output power from 100-/spl um/m aperture-broadened waveguide GRINSCH QW GaAs/AlGaAs(λ=0.81/spl um/m)and SCHDQW InGaAs/InGaAsP(λ=0.97/spl um/m laser diodes (2005)

High-power continuous wave operation from broadened waveguide (BW) graded-index-separate-confinement-heterostructure (GRINSCH) GaAs/AlGaAs single quantum well (SQW)λ=0.81 μm diodes and SCH double quantum well (DQW) Al-free, strained InGaAs/InGaAsP λ = 0,97 μm laser diodes has been described recently.1,2
[Delivery of gentamicin to the rabbit eye using hydrogel and iontophoresis]. (2006)

The aim of this study was to evaluate the use of solid hydrogel as a probe for the drug delivery to the rabbit eye upon application of low current iontophoresis. Hydroxyethyl methacrylate (HEMA), cross-linked with ethylenglycol dimethacrylate (EGDMA) were prepared to form solid hydrogels. The concentrations of gentamicin sulfate in different segments of rabbit eye after transconjunctival and transscleral iontophoresis were also studied. For iontophoresis we used a portable Mini Ion device (designed at Hebrew University of Jerusalem) and applied a current from 0 mA to 1.5 mA for pre-set period from 30 to 120 seconds and after application the concentrations of gentamicin in cornea were assayed. The rabbits in control group were treated with fortified gentamicin eye-drops (concentration 1.4 %). The highest concentration of gentamicin sulfate was reached after iontophoresis with current intensity of 1.5 mA applied for 60 s. High gentamicin concentration were found in the retina and in the sclera four hours after transscleral iontophoresis, the lowest concentration was obtained in vitreous. The delivery of gentamicin to the eye via iontophoresis with solid HEMA/EGDMA hydrogels seems to be promising method achieving high concentrations of the drug in the eye tissue.
Administration of Drugs/Gene Products to the Respiratory System: A Historical Perspective of the Use of Inert Liquids (2022)

The present review is a historical perspective of methodology and applications using inert liquids for respiratory support and as a vehicle to deliver biological agents to the respiratory system. As such, the background of using oxygenated inert liquids (considered a drug when used in the lungs) opposed to an oxygen-nitrogen gas mixture for respiratory support is presented. The properties of these inert liquids and the mechanisms of gas exchange and lung function alterations using this technology are described. In addition, published preclinical and clinical trial results are discussed with respect to treatment modalities for respiratory diseases. Finally, this forward-looking review provides a comprehensive overview of potential methods for administration of drugs/gene products to the respiratory system and potential biomedical applications.
Quantum Nano-Photonic Devices Based on Rare-Earth Doped Crystals (2014)

Rare-earth ions in crystalline hosts are coupled to nano-resonators, thus enabling large Purcell factors and high optical depths in micron-long structures. These devices will enable dense on-chip optical quantum memories and new quantum bits.
Electronic Promotion of Methanol Synthesis over Cu-Loaded ZnO-Based Catalysts (2023)

Methanol, a raw material for C1 chemistry, is industrially produced under harsh conditions using Cu/ZnO-based catalysts. The synthesis of methanol under mild conditions is a challenging subject using an improved catalyst. Here, Zn<sub>1-<i>x</i></sub>Si<sub><i>x</i></sub>O (ZSO) nanoparticles were synthesized by a thermal plasma method, and their work function and carrier concentration could be tuned by the Zn:Si ratio. The electrically conductive ZSO nanoparticles with a low work function enhanced the donation of electrons to loaded Cu and significantly promoted hydrogenation of CO to methanol, whereas insulating ZSO nanoparticles with a similar low work function did not. These results reveal that efficient electronic promotion by the transfer of electrons from a support to loaded Cu plays a key role in low-temperature methanol synthesis.
Synthesis of nanobelt-like 1-dimensional silver/nanocarbon hybrid materials for flexible and wearable electronics (2017)

Most synthetic processes of metallic nanostructures were assisted by organic/inorganic or polymeric materials to control their shapes to one-dimension or two-dimension. However, these additives have to be removed after synthesis of metal nanostructures for applications. Here we report a straightforward method for the low-temperature and additive-free synthesis of nanobelt-like silver nanostructures templated by nanocarbon (NC) materials via bio-inspired shape control by introducing supramolecular 2-ureido-4[1H]pyrimidinone (UPy) groups into the NC surface. The growth of the Ag nanobelt structure was found to be induced by these UPy groups through observation of the selective formation of Ag nanobelts on UPy-modified carbon nanotubes and graphene surfaces. The synthesized NC/Ag nanobelt hybrid materials were subsequently used to fabricate the highly conductive fibres (>1000S/cm) that can function as a conformable electrode and highly tolerant strain sensor, as well as a highly conductive and robust paper (>10000S/cm after thermal treatment).
Tracer Chromatographic Study of Pore and Pore Mouth Adsorption of Linear and Monobranched Alkanes on ZSM-22 Zeolite (2002)

The adsorption equilibria of a series of n-alkanes and 2-methyl- and 3-methyl-branched alkanes in the C5−C9 range on ZSM-22 zeolite samples were determined using the tracer chromatographic technique at temperatures between 343 and 623 K. Adsorption experiments were performed with a calcined ZSM-22 sample referred to as “open” ZSM-22 and an as-synthesized ZSM-22 zeolite sample in which the 1,6-diaminohexane template was left inside the pores, denoted as “closed” ZSM-22. In the “open” ZSM-22, the zeolite micropores are available for adsorption. In the “closed” ZSM-22, adsorption can occur in the pore mouths and on the external surface. The closing of the channels of ZSM-22 results in a significant decrease in the Henry constant and adsorption enthalpy and entropy of linear alkane molecules. Contrarily, the adsorption enthalpy and entropy of branched alkanes on “open” and “closed” ZSM-22 are nearly identical, indicating that the preferred adsorption sites for monobranched alkanes are not located inside the pores, but specifically at the entrance of the pore. For the pore mouth adsorption mode, a characteristic compensation between adsorption enthalpy and entropy was observed. The entropy losses upon adsorption inside the narrow ZSM-22 channels are much larger than in channel openings. These data support the pore mouth catalysis model for alkane hydro-isomerization on ZSM-22 type catalysts.
Fault diagnosis for a turbine engine (2000)

We deal with a sophisticated component level model (CLM) simulation of a turbine engine (XTE46) that can simulate the effects of manufacturing and deterioration differences, in addition to a variety of failures. To develop a fault diagnosis system we begin by using the CLM to generate data that is used by the Levenberg-Marquardt method to train a Takagi-Sugeno fuzzy system to represent the engine. The multiple copies of this nonlinear model, each representing a different failure, are then used to generate error residuals by comparing them to the engine output. In fact, we manage the composition of the set of models with a "supervisor" that ensures the appropriate models are online, and that processes the error residuals to detect and identify faults. The robustness of the approach is analyzed and several simulations are conducted to illustrate the effectiveness of the method.
Experimental Investigation Of Heat Transfer Characteristics Of Nanofluid Using Parallel Flow, Counter Flow And Shell And Tube Heat Exchanger (2015)

Abstract Cooling is indispensable for maintaining the desired performance and reliability over a very huge variety of products like electronic devices, computer, automobiles, high power laser system etc. Apart from the heat load amplification and heat fluxes caused by many industrial products, cooling is one of the major technical challenges encountered by the industries like manufacturing sectors, transportation, microelectronics, etc. Normally water, ethylene glycol and oil are being used as the fluid to carry away the heat in these devices. The development of nanofluid generally shows a better heat transfer characteristics than the water. This research work summarizes the experimental study of the forced convective heat transfer and flow characteristics of a nanofluid consisting of water and 1% Al 2 O 3 (volume concentration) nanoparticle flowing in a parallel flow, counter flow and shell and tube heat exchanger under laminar flow conditions. The Al 2 O 3 nanoparticles of about 50 nm diameter are used in this work. Three different mass flow rates have been selected and the experiments have been conducted and their results are reported. This result portrays that the overall heat transfer coefficient and dimensionless Nusselt number of nanofluid is slightly higher than that of the base liquid at same mass flow rate at same inlet temperature. From the experimental result it is clear that the overall heat transfer coefficient of the nanofluid increases with an increase in the mass flow rate. It shows that whenever mass flow rate increases, the overall heat transfer coefficient along with Nusselt number eventually increases irrespective of flow direction. It was also found that during the increase in mass flow rate LMTD value ultimately decreases irrespective of flow direction. However, shell and tube heat exchanger provides better heat transfer characteristics than parallel and counter flow heat exchanger due to multi pass flow of nanofluid. The overall heat transfer coefficient, Nusselt number and logarithmic mean temperature difference of the water and Al 2 O 3 /water nanofluid are also studied and the results are plotted graphically.
Supplementary Table 1 from TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase (2023)

&lt;p&gt;PDF file, 76K, Relation between TIG1 expression status and clinicopathologic factors of the IBC patient tissues.&lt;/p&gt;
Uncertainty Propagation and Trust Building in Visual Analytics (2014)

Visual analytics combines human and machine abilities to generate new knowledge from data. Within this process, uncertainty often plays an important role in hindering the sensemaking process and analysis tasks. On the machine side, uncertainty builds up from the data source level to the visual output. On the human side, these uncertainties often result in “lack of knowledge or trust” or “overtrust.” Such human’s biased interpretation can be resolved if we can measure uncertainties and users’ trust at each stage and provide proper mitigation in time. We believe that we can achieve this by tracing data provenance and analytic provenance accurately and reflecting them on the system output. Therefore, our first goal is to identify the roles of uncertainty and trust along the entire visual analytics knowledge generation process. In addition, we aim to capture how uncertainty and trust can be derived from data and analytic provenance. In this workshop, we introduce a framework that describes the roles of uncertainty and trust, and introduce open research questions with potential solutions.
Supplementary Materials from Efficacy of Weekly Docetaxel and Bevacizumab in Mesenchymal Chondrosarcoma: A New Theranostic Method Combining Xenografted Biopsies with a Mathematical Model (2023)

Supplementary Materials from Efficacy of Weekly Docetaxel and Bevacizumab in Mesenchymal Chondrosarcoma: A New Theranostic Method Combining Xenografted Biopsies with a Mathematical Model
Broad-bandwidth optical gain and efficient wavelength conversion in silicon waveguides (2006)

We use phase-matched four-wave mixing in appropriately designed silicon waveguides to demonstrate amplification over a 29 nm range and efficient wavelength conversion in the range from 1511 nm to 1591 nm.
Pharmacological and endocrine characterization of A‐198401, an orally active GnRH antagonist, in intact and castrate male rat models (2001)

Abstract Gonadotropin‐releasing hormone (GnRH) stimulates the synthesis and secretion of the gonadotropins that maintain the reproductive axis in mammals. Efforts have focused on the characterization of novel, nonpeptidic orally active antagonists of the GnRH receptor. An erythromycin A derivative, A‐198401 (11‐deoxy‐11‐[carboxy (3,4‐dichlorophenethyl) amino]‐3‐O‐[4‐(S)‐methyl‐oxazolidin‐2‐one] carbamoyl‐5‐O‐(3′‐N‐desmethyl‐3′‐N‐cyclopropylmethyl) desosaminyl‐6‐O‐methyl‐erythronolide A 11,12‐(cyclic carbamate), showed nanomolar affinity for the human (CHO‐21) and rat GnRH receptors in vitro (pK values 8.7 ± 0.2 and 9.2 ± 0.14, respectively). In a functional in vitro assay, A‐198401 inhibited leuprolide‐induced release of luteinizing hormone (LH) from cultured rat pituitary cells with a pA 2 value of 8.8. Intravenous (IV) dosing of A‐198401 in castrate male rats produced a significant dose‐dependent suppression of LH production with an ED 80 value of 5.26 mg/kg. Sustained testosterone (T) suppression was observed after IV dosing of A‐198401 in the intact rat, with a 10‐mg/kg‐dose producing 9–24 h suppression. Analysis of the IV and PO data indicate that A‐198401 has a bioavailability of 15%. A‐198401 is a novel nonpeptide GnRH antagonist that produces significant and sustained suppression of LH and T production in animal models when dosed either IV or PO and may provide the basis for a therapeutic GnRH antagonist for the clinical treatment of reproductive hormone‐dependent diseases. Drug Dev. Res. 52:485–491, 2001. © 2001 Wiley‐Liss, Inc.
Synthesis and biological properties of [2-L-.beta.-(pyrazolyl-3)alanine]-luteinizing hormone-releasing hormone (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and biological properties of [2-L-.beta.-(pyrazolyl-3)alanine]-luteinizing hormone-releasing hormoneDavid H. Coy, Esther J. Coy, Yoshihiro Hirotsu, and Andrew V. SchallyCite this: J. Med. Chem. 1974, 17, 1, 140–142Publication Date (Print):January 1, 1974Publication History Published online1 May 2002Published inissue 1 January 1974https://pubs.acs.org/doi/10.1021/jm00247a030https://doi.org/10.1021/jm00247a030research-articleACS PublicationsRequest reuse permissionsArticle Views42Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Proton Conduction in SnP[sub 2]O[sub 7]–LaP[sub 3]O[sub 9] Composite Electrolytes (2008)

The properties of proton-conducting composite electrolytes containing are reported. These electrolytes demonstrate both improved stability and enhanced proton conductivities when compared to their individual constituents. Two different methods were used to prepare samples: sintering or warm-pressing. A conductivity of was obtained for warm-pressed (Sn:La, 82:18) at . Under fuel cell conditions the composite with composition Sn:La, 82:18 exhibited the highest open-circuit voltage (OCV) of at . The OCV values confirmed that the electrolytes were predominantly ionically-conducting.
Photoelectron spectroscopy of f-element organometallic complexes. 4. Comparative studies of bis(pentamethylcyclopentadienyl) dichloride and dimethyl complexes of uranium(IV), thorium(IV), and zirconium(IV) (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoelectron spectroscopy of f-element organometallic complexes. 4. Comparative studies of bis(pentamethylcyclopentadienyl) dichloride and dimethyl complexes of uranium(IV), thorium(IV), and zirconium(IV)Enrico Ciliberto, Giuseppe Condorelli, Paul J. Fagan, Juan M. Manriquez, Ignazio Fragala, and Tobin J. MarksCite this: J. Am. Chem. Soc. 1981, 103, 16, 4755–4759Publication Date (Print):August 1, 1981Publication History Published online1 May 2002Published inissue 1 August 1981https://pubs.acs.org/doi/10.1021/ja00406a016https://doi.org/10.1021/ja00406a016research-articleACS PublicationsRequest reuse permissionsArticle Views169Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of inclusion size and orientation on rolling contact fatigue crack initiation observed by laminography using ultra-bright synchrotron radiation (2016)

The rolling contact fatigue (RCF) tests were performed on a high-strength steel by a newly developed compact rolling contact fatigue test machine, and the formation and propagation of cracks were observed by the synchrotron radiation computed laminography (SRCL). An increase in the sulfur concentration, i.e., increase in inclusion length, resulted in an increase in the variation of flaking life, and materials with horizontal inclusion showed large variation compared to those with vertical inclusion although average flaking lives are almost identical. In the flaking process, cracks, those were perpendicular to the rolling surface and rolling direction, first formed from an inclusion that was adjacent to the rolling surface. Then, the crack propagated in the depth direction. After the vertical crack propagated to a critical depth, a horizontal crack formed, whose face was parallel to the rolling surface. Finally, the horizontal crack propagated to form flaking.
Abstract 583: RNAi Therapeutics For The Lowering Of Cholesterol (2007)

Delivery of small interfering RNAs (siRNAs) in vivo , using clinically relevant modes of administration, is critical for the advancement of RNA interference (RNAi) therapeutics. In this work, we demonstrate systemic delivery of siRNAs and potent in vivo down-modulation of two important disease targets, apolipoprotein B (apoB) and proprotein convertase subtilisin kexin 9 (PCSK9). A single injection of liposomal siRNA resulted in &gt;90% silencing of apoB mRNA expression in the liver 48 h after administration. The effect was demonstrated to occur through cleavage of the apoB mRNA at precisely the site predicted for the RNAi mechanism. Reductions in apoB protein, cholesterol, and low-density lipoprotein (LDLc) levels were observed in 48 hours that lasted for at least 23 days, thus demonstrating an immediate, potent and durable biological effect. In addition to apoB we have also demonstrated the ability to down-modulate other important liver targets such as PCSK9. PCSK9 has been closely implicated in LDLc regulation. We have demonstrated PCSK9 down-modulation in several animal models including, mouse, humanized mouse, rat, and non-human primate. Down-modulation of PCSK9 levels resulted in significant lowering of cholesterol (20 – 60%) in all animal models tested. These findings strongly support the potential of RNAi therapeutics as a new class of drug for metabolic and cardiovascular diseases. Our next steps include selecting the most potent lead molecule and moving it into GLP safety studies.
Multi-Color Electrochromic Polymer Coatings (2000)

Abstract : We have developed new routes to prepare a series of derivatized electron-rich carbazole polymers containing polar ion transport, solubilizing, and redox active pendant substituents providing both multiple redox and multiple color states for electrochromic coatings. A series of electroactive (electrochromic and electroluminescent) conjugated polyelectrolytes based on 1,4-phenylene and 2,5-thienylenen linkages and containing both sulfonate and ammonium ion derivatized have been prepared. These polymers have been used in layer-by-layer electrostatic deposition processes for the preparation of electrochromic coatings, along with LED's.