gebhart/patrepeval huggingface dataset:
Fair Bandwidth Allocation and Buffer Management in Hybrid Network Gateways (2000)

In this paper, we present an efficient and fair resource allocationscheme for scheduling and buffer management in a bottleneck hybridsatellite-terrestrial network gateway with per-flow TCP queues. Ourfirst contribution is the use of Fair Queueing in conjunction withProbabilistic Fair Drop, a new buffer management policy to allocatebandwidth and buffer space in the gateway, to ensure that all TCPflows threading the gateway achieve high end-to-end throughput andfair service. Our second contribution is to introduce the concept ofbuffer dimensioning to alleviate the inherent bias of the TCPalgorithm towards connections with large Round Trip Time. In supportof each of these contributions, we report on extensive simulationresults. Our scheme outperforms other resource allocation schemesreported in the literature and in particular, demonstrates significantimprovements in fairness to long RTT connections in the hybrid networkframework.
Fluoride-Mediated Boronic Acid Coupling Reactions (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluoride-Mediated Boronic Acid Coupling ReactionsStephen W. Wright, David L. Hageman, and Lester D. McClureCite this: J. Org. Chem. 1994, 59, 20, 6095–6097Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/jo00099a049https://doi.org/10.1021/jo00099a049research-articleACS PublicationsRequest reuse permissionsArticle Views5465Altmetric-Citations291LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Hybrid Analytic Flows - the Case for Optimization (2013)

To remain competitive, enterprises are evolving in order to quickly respond to changing market conditions and customer needs. In this new environment, a single centralized data warehouse is no longer sufficient. Next generation business intelligence
Case Report: Metastatic Parosteal Osteosarcoma in a Dog (2021)

This case report describes a rare form of malignant bone tumor in an 8-year-old Labrador retriever. This dog initially presented for evaluation of a right distal humeral mass. Radiographs of the right elbow and thorax were performed, revealing a smooth mineralized mass adjacent to the lateral aspect of the distal humerus and a 5mm pulmonary nodule. Computed tomography (CT) of the humerus and thorax showed a smooth mineralized lesion adjacent to the lateral humeral epicondyle, and a right cranial lung lobe nodule with a thin mineral rim. Surgical biopsies of both lesions were diagnostic for parosteal osteosarcoma (POSA). The dog was then treated with stereotactic body radiation therapy (SBRT) which controlled the dog's discomfort for 14 months until he became progressively painful and subsequently had his right forelimb amputated. This case report is the first to document the CT imaging characteristics of a metastatic appendicular POSA in a dog and the first dog described with POSA treated with SBRT. The dog lived for 623 days after histopathologic diagnosis and 849 days after initial presentation with pulmonary metastatic disease.
Increased Binding of Epidermal Growth Factor at Preimplantation Sites in Mouse Uteri (1989)

The presence of receptors for epidermal growth factor (EGF) in nonpregnant uteri and the elevation of EGF levels in blood during early pregnancy suggest that EGF and its receptor may play important roles in the early stages of pregnancy. We determined the distribution of EGF receptors in uteri of nonpregnant and pregnant mice during the late preimplantation period (days 4.5-5.0 of pregnancy) using radioautograph and quantitative binding techniques. Radioautography of [125I]EGF binding to cornua from nonpregnant mice showed low levels of specific binding evenly distributed throughout the cornua. In contrast, radioautographs of cornua from pregnant mice showed bands of elevated binding encircling the lumen at sites of preimplantation. Results from radioautography were supported by quantitative analysis of [125I]EGF binding to uterine homogenates from nonpregnant and pregnant mice. Binding of [125I]EGF to uterine membranes was highly specific and time dependent. The average level of specific EGF binding calculated from Scatchard plots of nonpregnant uteri (27 +/- 13 fmol/mg protein) was significantly (P less than 0.05) lower than that in pregnant superovulated uteri (106 +/- 67 fmol/mg protein). Furthermore, specific binding of EGF was significantly (P less than 0.05) higher in preimplantation sites than in the intervening nonimplantation regions from the same uteri (42 +/- 6 vs. 29 +/- 4 fmol/mg protein, respectively). Differences in EGF binding appear to be due to changes in the number of EGF receptors, since half-displacement values (1 nM) were similar in all samples. These results demonstrate that alterations of EGF receptor levels occur at sites where implantation will occur in mouse uteri and support the concept that the transforming growth factor-alpha/EGF receptor and its ligands are involved in implantation of concepti.
Oxide Nanoparticle EUV (ONE) Photoresists: Current Understanding of the Unusual Patterning Mechanism (2015)

In the past few years, industry has made significant progress to deliver a stable high power EUV scanner and a 100 W light source is now being tested on the manufacuring scale. The success of a high power EUV source demands a fast and high resolution EUV resist. However, chemcially amplied resists encounter unprecedented challenges beyond the 22 nm node due to resolution, roughness and sensitivity tradeoffs. Unless novel solutions for EUV resists are proposed and further optimzed, breakthroughs can hardly be achieved. Oxide nanoparticle EUV (ONE) resists stablized by organic ligands were originally proposed by Ober et al. Recently this work attracts more and more attention due to its extraordinanry EUV sensitivity. This new class of photoresist utilizes ligand cleavage with a ligand exchange mechanism to switch its solubilty for dual-tone patterning. Therefore, ligand selection of the nanoparticles is extremely important to its EUV performance.
Dense SDM (12-Core x 3-Mode) Transmission Over 527 km With 33.2-ns Mode-Dispersion Employing Low-Complexity Parallel MIMO Frequency-Domain Equalization (2015)

We propose long-haul space-division-multiplexing (SDM) transmission systems employing parallel multiple-input multiple-output (MIMO) frequency-domain equalization (FDE) and transmission fiber with low differential mode delay (DMD). We first discuss the advantages of parallel MIMO FDE technique in long-haul SDM transmission systems in terms of the computational complexity, and then, compare the complexity required for parallel MIMO FDE as well as the conventional time-domain equalization techniques. Proposed parallel MIMO FDE that employs low baud rate multicarrier signal transmission with a receiver-side FDE enables us to compensate for 33.2-ns DMD with considerably low-computational complexity. Next, we describe in detail the newly developed fiber and devices we used in the conducted experiments. A graded-index (GI) multicore few-mode fiber (MC-FMF) suppressed the accumulation of DMD as well as intercore crosstalk. Mode dependent loss/gain effect was also mitigated by employing both a ring-core FM erbium-doped fiber amplifier and a free-space optics type gain equalizer. By combining these advanced techniques together, we finally demonstrate 12-core × 3-mode dense SDM transmission over 527-km GI MC-FMF without optical DMD management.
Comparative Biology of Cystic Fibrosis Animal Models (2011)

Animal models of human diseases are critical for dissecting mechanisms of pathophysiology and developing therapies. In the context of cystic fibrosis (CF), mouse models have been the dominant species by which to study CF disease processes in vivo for the past two decades. Although much has been learned through these CF mouse models, limitations in the ability of this species to recapitulate spontaneous lung disease and several other organ abnormalities seen in CF humans have created a need for additional species on which to study CF. To this end, pig and ferret CF models have been generated by somatic cell nuclear transfer and are currently being characterized. These new larger animal models have phenotypes that appear to closely resemble human CF disease seen in newborns, and efforts to characterize their adult phenotypes are ongoing. This chapter will review current knowledge about comparative lung cell biology and cystic fibrosis transmembrane conductance regulator (CFTR) biology among mice, pigs, and ferrets that has implications for CF disease modeling in these species. We will focus on methods used to compare the biology and function of CFTR between these species and their relevance to phenotypes seen in the animal models. These cross-species comparisons and the development of both the pig and the ferret CF models may help elucidate pathophysiologic mechanisms of CF lung disease and lead to new therapeutic approaches.
Genetics of Healthy Aging in Europe (2007)

The aim of the 5-year European Union (EU)-Integrated Project GEnetics of Healthy Aging (GEHA), constituted by 25 partners (24 from Europe plus the Beijing Genomics Institute from China), is to identify genes involved in healthy aging and longevity, which allow individuals to survive to advanced old age in good cognitive and physical function and in the absence of major age-related diseases. To achieve this aim a coherent, tightly integrated program of research that unites demographers, geriatricians, geneticists, genetic epidemiologists, molecular biologists, bioinfomaticians, and statisticians has been set up. The working plan is to: (a) collect DNA and information on the health status from an unprecedented number of long-lived 90+ sibpairs (n = 2650) and of younger ethnically matched controls (n = 2650) from 11 European countries; (b) perform a genome-wide linkage scannning in all the sibpairs (a total of 5300 individuals); this investigation will be followed by linkage disequilibrium mapping (LD mapping) of the candidate chromosomal regions; (c) study in cases (i.e., the 2650 probands of the sibpairs) and controls (2650 younger people), genomic regions (chromosome 4, D4S1564, chromosome 11, 11.p15.5) which were identified in previous studies as possible candidates to harbor longevity genes; (d) genotype all recruited subjects for apoE polymorphisms; and (e) genotype all recruited subjects for inherited as well as epigenetic variability of the mitochondrial DNA (mtDNA). The genetic analysis will be performed by 9 high-throughput platforms, within the framework of centralized databases for phenotypic, genetic, and mtDNA data. Additional advanced approaches (bioinformatics, advanced statistics, mathematical modeling, functional genomics and proteomics, molecular biology, molecular genetics) are envisaged to identify the gene variant(s) of interest. The experimental design will also allow (a) to identify gender-specific genes involved in healthy aging and longevity in women and men stratified for ethnic and geographic origin and apoE genotype; (b) to perform a longitudinal survival study to assess the impact of the identified genetic loci on 90+ people mortality; and (c) to develop mathematical and statistical models capable of combining genetic data with demographic characteristics, health status, socioeconomic factors, lifestyle habits.
A Clinical Study on Deep Neck Infection (2006)

Deep neck infection (DNI) remains an emergent and life-threatening otolaryngologic disease. We examined 69 patients, 52 men and 17 women, with DNI, who were treated in our hospital between January 1995 and December 2004. The mean age of the patients with DNI was 50.0 years and the peak incidence was in the sixth decade. Twenty patients suffered from diabetes mellitus (DM). The primary DNI lesion was found in the tonsils in 34 cases, the oral cavity in 16 cases, and the pharynx in 12 cases, respectivelys. Among the 69 patients with DNI, the infection remained in the suprahyoid region in 31 cases, but it extended to the infrahyoid region in 33 cases and to the mediastinum in 5 cases. The titer of C-reacting protein (CRP) and the duration of admission were considered as parameters of the severity of DNI. CRP was significantly higher in elderly patients, in patients with DM, and in patients whose infection extended to the infrahyoid region and to the mediastinum, however, significant difference was not found between men and women, or among the types of primary DNI lesions. Moreover, the duration of admission was significantly longer in elderly patients, in patients with DM, and in patients with infrahyoid and mediastinal DNI, whereas no significant differences were found between men and women or among the types of primary lesions. Therefore, age, DM, and the extension of DNI are considered to be important factors which determining the severity of DNI.
Discovering correctness constraints for self-management of system con .guration (2004)

Managing the configuration of computer systems is a difficult task. Too easily, a computer user or administrator can make a simple mistake and misconfigure a system, causing instabilities, unexpected behavior, and general unreliability. Bugs in software that changes these configurations, such as installers, only worsen the situation. A self-managing configuration system should be continuously monitoring itself for invalid settings, preventing the bugs from harming the system. Unfortunately, while there are many constraints which can differentiate between valid and invalid settings, few are explicitly written down, much less written down in a form usable by an automatic monitor. We propose an approach to automatically infer these correctness constraints based on samples of known good configurations. In this paper we present Glean, a system for analyzing the structure of configurations and automatically inferring four types of correctness constraints on that structure.
Organelle‐targeting, red‐emitting fluorescent probes with superior photo‐physical properties for multiplexing with green fluorescent protein (GFP) in live cells (2009)

Cell‐based assays are increasingly gaining in popularity in the biotechnology and pharmaceutical industry due to their high physiological relevance. As trends advance toward analysis of living biological systems, fluorescent proteins (such as GFPs) have become indispensable tools for live‐cell analysis. One important application of GFPs is fluorescence co‐localization imaging, a powerful approach for exploring the targeting of molecules to intracellular compartments and for screening of their associations and interactions. To date, however, concerted efforts in developing fluorescent organelle‐targeting probes, specifically tailored to working in concert with GFPs, has been limited. Photo‐conversion of red‐fluorescent dyes to fluoresce green and metachromatic artifacts wherein fluorescent dyes emit both red and green lead to spurious results in GFP co‐localization experiments. Additionally, many organelle‐targeting probes photo‐bleach rapidly, are subject to quenching upon concentration in organelles or only transiently associate with the target organelle, requiring imaging within a minute of dye addition. Consequently, a new family of red‐emitting, cell‐permeable probes that spontaneously localize to specific subcellular organelles was developed. It is demonstrated that the probes can be readily used in combination with other common UV‐ and visible‐light excitable organic fluorescent dyes and various fluorescent proteins in multi‐color imaging and detection applications. It is further shown that the probes emit in the Texas Red region of the visible spectrum, and are highly resistant to photo‐bleaching, concentration quenching and photo‐conversion.
ChemInform Abstract: METHODOLOGY FOR INDOLE SYNTHESIS (1981)

Abstract Aus den 2‐Brom‐N‐acylanilinen (I) entstehen die Dilithio‐Derivate (II), die mit 2‐Chlor‐cyclohexanon (III) zu den Hydroxy‐carbazolen (IV) reagieren.
Solid-Phase Pyrrolidine Synthesis via 1,3- Dipolar Cycloaddition of Azomethine Ylides Generated by the Decarboxylative Route (2006)

Although solid-phase pyrrolidine synthesis via dipolar cycloaddition of ester-stabilized azomethine ylides has been demonstrated on several occasions, this reaction with nonstabilized azomethine ylides, generated on solid support by a decarboxylative pathway, has never been reported.Herein we present the first solid-phase synthesis of pyrrolidines via this route and demonstrate that the reacting azomethine ylide can be generated both from a resin-bound aldehyde or amino acid.Using cyclic and acyclic dipolarophiles, bi-and monocyclic resin-bound pyrrolidines were obtained.The modest to high degree of regioand diastereoselectivity observed in the reaction can be tuned by the substituents of the partners of this three-component process.Pyrrolidine heterocycle-containing alkaloids are known for their biological activities, 1,2 and accordingly, a number of combinatorial libraries of pyrrolidines were prepared over the last few years.High throughput screening techniques revealed bioactive leads for future drug development in these libraries. 3 Solid-Phase Organic Synthesis (SPOS) is one of the core techniques for the preparation of combinatorial libraries due to its ability to create arrays of diverse polyfunctional molecules in an easy, clean and fast fashion.One of the major routes to pyrrolidines proceeds through 1,3-dipolar cycloaddition, based on the formation of an azomethine ylide (e.g. from an aldehyde and amino acid in situ) followed by reaction with an olefin. 4This one-pot reaction enables the preparation of diverse poly-and mono-cyclic
Different abilities of Friend murine leukemia virus (MuLV) and Moloney MuLV to induce promonocytic leukemia are due to determinants in both psi-gag-PR and env regions (1994)

Moloney murine leukemia virus (M-MuLV) is capable of inducing promonocytic leukemia in 50% of adult BALB/c mice that have received peritoneal injections of pristane, but Friend MuLV strain 57 (F-MuLV) is nonleukemogenic under similar conditions. It was shown earlier that these differences could not be mapped to the U3 region of the virus long terminal repeat, indicating the probable influence of structural genes and/or R-U5 sequences. In this study, reciprocal chimeras containing exchanged structural genes and R-U5 sequences from these two closely related viruses were analyzed for differences in ability to induce disease. Results showed that two regions of F-MuLV, psi-gag-PR and env, when substituted for those of M-MuLV were dramatically disease attenuating. The 5'-most region, which is widely distributed, overlaps with the 5' end of the env intron and includes the RNA packaging region, psi, the entire gag coding region, and the viral protease coding region (PR) of pol. It was also found that reciprocal constructs having substitutions of both of these regions of M-MuLV in an F-MuLV background allowed full reestablishment of promonocytic leukemia. These leukemias were positive for c-myb rearrangements which are characteristic of M-MuLV-induced promonocytic leukemias. Neither region alone, however, was sufficient to produce disease with a greater incidence than 13%. Further studies demonstrated that the inability of viruses with psi, gag, PR, or env sequences from F-MuLV to induce leukemia in this model system was not due to their inability to replicate in hematopoietic tissue, to integrate into the c-myb locus early on after infection in vivo, or to express gag-myb mRNA characteristic of M-MuLV-induced preleukemic cells and acute leukemia.
Reducing Transient Disconnectivity using Anomaly- Cognizant Forwarding (2008)

It is well known that BGP convergence can cause widespread temporary losses of connectivity resulting from inconsistent routing state. In this paper, we present Anomaly-Cognizant Forwarding (ACF)- a novel technique for protecting end-to-end packet delivery during periods of convergence. Our preliminary evaluation demonstrates that ACF succeeds in eliminating nearly all transient disconnection after a link failure without the use of precomputed backup routes or altering the dynamics of BGP. 1
Variation of gravure coating thickness during early stages of doctor blade wear (1999)

Abstract With all operating parameters fixed, the mean coated thickness in gravure coating should ideally be a constant fraction of the volume factor of the engraving, and, hence, invariant over coated distance. Experimental data presented, however, reveal an unexpected variation of gravure coating thickness over the first few thousand meters of coated web. The observed variation is attributed to wear of the blade tip. The lubrication approximation is invoked to model a series of steady‐state flows between blade tips of various profiles and a smooth surface at a fixed gap away from them. The blade tip profiles are chosen to simulate those of a continously wearing blade tip. The resulting four‐parameter model is used to “fit” experimental data of gravure coating thickness variation. Then, the model is used to predict the effects of various operating parameters, including coating liquid properties, blade thickness, blade setup, and web speed, on this phenomenon.
Gene expression regulating epithelial intercellular junction biogenesis during human blastocyst development in vitro (2003)

We investigated gene expression associated with trophectoderm epithelial intercellular junction formation in single human embryos at different stages of cleavage using RT-PCR methods based upon magnetic bead separation of polyA+ RNA. Trophectoderm tight junction (TJ) and desmosome biogenesis contribute to intercellular sealing and tissue integrity, critical for vectorial transport and blastocoel cavity formation. Expression of the various genes throughout human preimplantation development showed differing levels of sensitivity of detection; these genes included claudin-1, occludin (TM4+ and TM4 isoforms), ZO-1 (ZO-1alpha+ and ZO-1alpha- isoforms), ZO-2 and JAM (junction adhesion molecule), and the desmosome junction gene, DSC2 (desmocollin 2). Some transcripts appeared to be expressed throughout preimplantation development (claudin-1, JAM, occludin TM4+ and TM4, ZO-1alpha- isoform) while others tended to be expressed preferentially in later cleavage and associated with blastocyst formation (ZO-2, ZO-1alpha+ isoform, DSC-2), illustrating an expression pattern broadly similar to mouse cleavage stages. Human embryo transcript detection was significantly decreased when reverse transcription was performed in solid phase to generate a bead/cDNA transient library rather than after mRNA elution from beads. Transcript detection tended to be positively correlated with embryo morphological grade using the solid phase method. In blastocysts, occludin TM4-, ZO-1alpha+ and DSC2 transcripts were the most susceptible to failure of detection, indicative of low levels of expression which may impact on trophectoderm differentiation competence. Immunoconfocal microscopy analysis of selected adhesion and TJ proteins in human embryos indicated poor membrane assembly compared with mouse blastocysts, which may further affect embryo viability.