gebhart/patrepeval huggingface dataset:
Evaluation of KPT-SINE (Selective Inhibitors of CRM1-Mediated Nuclear Export) in AML and T-ALL. (2012)

e13586 Background: CRM1 is the major nuclear exporter that mediates transport of a variety of molecules, including proteins involved in tumor suppressor and cellular proliferation pathways. The crystal structure of CRM1, in complex with its export cargo, Snurportin 1, has been recently resolved. The molecular understanding of the CRM1-cargo binding interface has led to the development of novel small molecule inhibitors of CRM1-cargo interaction, termed KPT-Selective Inhibitors of Nuclear Export (SINE). KPT-SINE are potent, drug-like CRM1 inhibitors that irreversibly inactivate the CRM1-directed protein export by covalent modification of the essential CRM1-cargo binding residue Cys528. The inhibition of the CRM1 nuclear export has been shown to lead to selective apoptosis in cancer cells when compared to normal cells. Here, we assess the efficacy of the KPT-SINE in human AML, T-ALL, and normal hematopoietic cells. Methods: The viability of a panel of human AML and T-ALL cell lines upon treatment by the KPT-SINE was assessed. Dose-response measurements were done using serial dilutions of KPT-SINE from 1 µM to 0.3 nM and luminescent cell viability assay. Apoptosis was measured using Annexin V staining and TUNEL assays. Results: KPT-SINE induces rapid apoptosis in 10 of 14 AML and 12 of 15 T-ALL cell lines with IC50s of 15-100 nM. In the KPT-SINE-sensitive cell lines, BCL2 overexpression suppresses KPT-SINE-induced apoptosis, indicating its intrinsic pathway mediation. Importantly, KPT-SINE compounds, either KPT-251 at 75 mg/kg or KPT-330 at 15 or 25 mg/kg, induced remarkable growth suppression in MV4-11 human AML cells engrafted into immunodeficient NSG mice with minimal toxicity to normal mouse hematopoietic cells after 35 days of treatment. Bone marrow biopsies of KPT-treated mice were remarkable in that they showed normal hematopoietic cell morphology and cellularity after 35 days of treatment. Xenograft studies to address the potency of the KPT-251 and KPT-330 on MOLT-4 human T-ALL cells in vivo are ongoing. Conclusions: These studies emphasize the clinical promise of the KPT-SINE as a novel and selective drug candidate for the treatment of AML and T-ALL.
25W average-power, second-harmonic-generation of a linearly-polarized Er fiber source in PPKTP and its application for tandem harmonic generation in UV (2004)

An Yb-Er, PM-format, quasi-CW fibre source with 1.2kW peak power is presented and used for 76% efficient SHG in PPKTP. The single-mode, 25W 775nm source was used for SHG at 388nm with average powers &gt;1W.
Phase Evaluation in Al 2 O 3 Fiber‐Reinforced Ti 2 AlC During Sintering in the 1300°C–1500°C Temperature Range (2011)

In this article, the reactivity of Ti 2 AlC powders, with 3 and 10 μm alumina, Al 2 O 3 , fibers during pressure‐assisted sintering is explored. Samples were fabricated by hot‐isostatic‐pressing ( HIP ed) or hot‐pressing ( HP ed), and characterized by X‐ray diffraction, differential thermal analysis, and electron microscopy—both scanning and transmission—equipped with energy dispersive X‐ray spectroscopes. Samples prepared at 1300°C were fully dense, with no apparent reaction between fiber and matrix. In samples HP ed to 1500°C, even pure Ti 2 AlC powders dissociated to Ti 3 AlC 2 according to: 2 Ti 2 AlC = Ti 3 AlC 2 + TiAl x ( l ) + (1‐ x ) Al ( l / v ), with x &lt; 1. More severe Al loss results in the formation of TiC y . The presence of the Al 2 O 3 fibers delayed densification enough to allow most of the Al and some of the Ti to escape into the vacuum of the hot press or react with the encapsulating glass during HIPing a resulting in a more intensive dissociation of the Ti 2 AlC . Although, in principle Ti 2 AlC can be reinforced with Al 2 O 3 fibers, the processing/use temperature will have to be kept below 1500°C, as, at that temperature the fibers, used here, sinter together.
Passive retrieval of Rayleigh waves in disordered elastic media (2005)

When averaged over sources or disorder, cross correlation of diffuse fields yields the Green's function between two passive sensors. This technique is applied to elastic ultrasonic waves in an open scattering slab mimicking seismic waves in the Earth's crust. It appears that the Rayleigh wave reconstruction depends on the scattering properties of the elastic slab. Special attention is paid to the specific role of bulk to Rayleigh wave coupling, which may result in unexpected phenomena, such as a persistent time asymmetry in the diffuse regime.
Total Synthesis and Stereochemistry of Cytoblastin (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTotal Synthesis and Stereochemistry of CytoblastinOfir A. Moreno and Yoshito KishiView Author Information Department of Chemistry, Harvard University Cambridge, Massachusetts 02138 Cite this: J. Am. Chem. Soc. 1996, 118, 34, 8180–8181Publication Date (Web):August 28, 1996Publication History Received31 May 1996Published online28 August 1996Published inissue 1 January 1996https://doi.org/10.1021/ja9618412Copyright © 1996 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views850Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (121 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amides,Conformation,Hydroxyls,Pharmaceuticals,Stereochemistry Get e-Alerts
Supplementary Materials and Methods from Transforming Growth Factor-β Activation Promotes Genetic Context–Dependent Invasion of Immortalized Melanocytes (2023)

Supplementary Materials and Methods from Transforming Growth Factor-β Activation Promotes Genetic Context–Dependent Invasion of Immortalized Melanocytes
Attacks on Onion Discovery and Remedies via Self-Authenticating Traditional Addresses (2021)

Onion addresses encode their own public key. They are thus self-authenticating, one of the security and privacy advantages of onion services, which are typically accessed via Tor Browser. Because of the mostly random-looking appearance of onion addresses, a number of onion discovery mechanisms have been created to permit routing to an onion address associated with a more meaningful URL, such as a registered domain name.
Solid-Phase Synthesis and Biological Evaluation of a Teleocidin Library—Discovery of a Selective PKC Down Regulator (2000)

Protein kinaseC (PKC) is linked to the signal-induced modulation of a wide variety of cellular processes, such as growth, differentiation, secretion, apoptosis, and tumor development. The design and synthesis of small molecules that regulate these different cellular signaling systems is at the forefront of modern drug design. Herein we report a) an efficient method for the synthesis of indolactamV (6), a PKC activator, and its N13-des(methyl) analogues (19) using a regioselective organometallic transformation, a convenient aminomalonate derivative (10) to introduce the appropriate functionality and an enantiospecific enzymic hydrolysis as key steps; b) the use of this method in the first solid-phase synthesis of a teleocidin library modifying the N-13, C-12 and C-7 alkyl chains, and, therefore, producing a library of potential activators and/or inhibitors of PKC of the general structure (32); c) the activation of PKC by selected members of the library using a MARCKS translocation in vivo assay system; d) the observation that some of these analogues are nearly as effective as the natural PKC activators phorbol dibutyrate and (-)-indolactam V (6), and e) the observation that some of these analogues have different potential to induce down-regulation of members of the PKC gene family after chronic stimulation.
Supplementary Data from Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-Producing Dendritic Cells (2023)

Supplementary Data from Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-Producing Dendritic Cells
Effect of anion on metal-organic halide perovskite film formation and the performance of plannar heterojunction device (2014)

Perovskite solar cells, which represent the promise of future generation photovoltaic technology&#13;\nwith the lowest cost and highest efficiency, have evoked widespread scientific and industrial interest.&#13;\nThrough rational device architecture design, materials interface engineering as well as processing&#13;\ntechnique optimization, a recorded efficiency around 18% has been attained, showing great potential&#13;\nfor commercialization to compete with traditional silicon solar cells. Although the device performance of&#13;\nperovskite solar cells improves unprecedently fast in last two years, the basic properties of metalorganic&#13;\nhalide perovskite, MAPbX3 (X=Cl, Br, I), such as the role of cation and anion, for example, are&#13;\nstill not well understood. Most of research focuses on the perovskite band gap tuning by changing the&#13;\nratio of either anions (Br to I) or cations (FA to MA). However, up to date, the effect of anion in&#13;\npercursor solution on the perovskite crystal growth and film formation has not been well studied yet,&#13;\nwhich is highly likely to correlate with the device performance. In addition, there is a long debate on the&#13;\nexistence and role of Cl in mixed-halide perovskite and the results from varied groups employing&#13;\ndifferent characterization techniques are quite controversial. Fully understanding of these questions is&#13;\ncritically important for the advancement of perovskite solar cell technology in the next few years. In this&#13;\nwork, the effect of anion was systematically studied and we found that anion in precursor solution has&#13;\ngreat influence on the perovskite crystal growth and film formation. By materials engineering, both film&#13;\nmorphology and processing time are greatly improved, which leads to enhanced performance in plannar&#13;\nheterojunction devices.
Enhanced spread spectrum aloha demodulator implementation, laboratory tests and satellite validation (2014)

SUMMARY This paper describes the implementation of the first enhanced spread spectrum aloha demodulator, based on an innovative architecture which combines software‐defined radio with processing via commercial graphics processing units. The validation tests performed both in laboratory conditions and directly on the satellite EUTELSAT 10A are presented. The performance assessment results obtained via satellite validate the theoretical results to a sufficient degree to make enhanced spread spectrum aloha technology a viable option for low‐power mobile and fixed terminals, thus encouraging the growth of satellite mass market applications. Copyright © 2014 John Wiley &amp; Sons, Ltd.
Blue matter on blue gene/L (2005)

This paper provides an overview of the Blue Matter application development effort within the Blue Gene project that supports our scientific simulation efforts in the areas of protein folding and membrane-protein systems. The design philosophy of the Blue Gene/L architecture relies on large numbers of power efficient nodes (whose technology is derived from the world of embedded microprocessors) to enable packing of many such nodes into a small volume to achieve high performance. In order for an application to exploit the potential of this architecture, the application must scale well to large node counts. Because the scientific goals of the project entail simulating very long time-scales, up to microseconds, strong scaling of a fixed size problem to these large node counts is a requirement. In pursuit of this objective we have considered a variety of parallel decompositions and explored ways to exploit and map algorithms onto the two primary high performance interconnects provided by the Blue Gene architecture, the 3D-torus network and the collective network. Our current version of the application continues to speed up through 4096 nodes and is being used for studies of a protein/lipid system (for which some results have already been published) and for protein folding/unfolding simulations.
Electrically adjustable location of a projected image in augmented reality via a liquid-crystal lens (2015)

An augmented reality (AR) system involving the electrically tunable location of a projected image is implemented using a liquid-crystal (LC) lens. The projected image is either real or virtual. By effectively doubling the LC lens power following light reflection, the position of a projected virtual image can be made to vary from 42 to 360 cm, while the tunable range for a projected real image is from 27 to 52 cm on the opposite side. The optical principle of the AR system is introduced and could be further developed for other tunable focusing lenses, even those with a lower lens power. The benefits of this study could be extended to head-mounted display systems for vision correction or vision compensation. We believe that tunable focusing LC optical elements are promising developments in the thriving field of AR applications.
Implication of the intestinal microbiome in complications of cirrhosis (2016)

The intestinal microbiome (IM) is altered in patients with cirrhosis, and emerging literature suggests that this impacts on the development of complications. The PubMed database was searched from January 2000 to May 2015 for studies and review articles on the composition, pathophysiologic effects and therapeutic modulation of the IM in cirrhosis. The following combination of relevant text words and MeSH terms were used, namely intestinal microbiome, microbiota, or dysbiosis, and cirrhosis, encephalopathy, spontaneous bacterial peritonitis, hepatorenal syndrome, variceal bleeding, hepatopulmonary syndrome, portopulmonary hypertension and hepatocellular carcinoma. The search results were evaluated for pertinence to the subject of IM and cirrhosis, as well as for quality of study design. The IM in cirrhosis is characterized by a decreased proportion of <i>Bacteroides</i> and <i>Lactobacilli</i>, and an increased proportion of <i>Enterobacteriaceae</i> compared to healthy controls. Except for alcoholic cirrhosis, the composition of the IM in cirrhosis is not affected by the etiology of the liver disease. The percentage of <i>Enterobacteriaceae</i> increases with worsening liver disease severity and decompensation and is associated with bacteremia, spontaneous bacterial peritonitis and hepatic encephalopathy. Lactulose, rifaximin and Lactobacillus-containing probiotics have been shown to partially reverse the cirrhosis associated enteric dysbiosis, in conjunction with improvement in encephalopathy. The IM is altered in cirrhosis, and this may contribute to the development of complications associated with end-stage liver disease. Therapies such as lactulose, rifaximin and probiotics may, at least partially, reverse the cirrhosis-associated changes in the IM. This, in turn, may prevent or alleviate the severity of complications.
Supplemental Table 3 from Characterization of an Immunogenic Mutation in a Patient with Metastatic Triple-Negative Breast Cancer (2023)

&lt;p&gt;Mutation expression in metastatic lesions at autopsy.&lt;/p&gt;
A Cyclobutadiene Equivalent in the Catalytic Pauson—Khand Reaction. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Converting carbohydrates to bulk chemicals and fine chemicals over heterogeneous catalysts (2011)

In this Critical Review, we discuss how carbohydrates can be transformed into a variety of chemicals through heterogeneous catalysis. We focus particularly on oxidation, reduction and dehydration of hexoses, as well as one-pot reactions of di- and polysaccharides. Most of the reactions involve heterogeneous catalysts, although some interesting homogeneously catalyzed processes are also included.
Large area growth of aligned carbon nanotubes on display glass (2004)

This paper deals with large area growth of vertically aligned CNTs on CF-77 and TFT glass substrates up to 6 inches square. The CNTs are grown at 550/spl deg/C using invar as a catalyst by initiating a DC glow discharge plasma of C/sub 2/H/sub 2/ and NH/sub 3/ at -600 V using an 10 kW DC generator.
Cervical and Thoracolumbar Spine Injury Evaluation, Transport, and Surgery in the Deployed Setting (2018)

This Cervical and Thoracolumbar Spine Injury Evaluation, Transport, and Surgery Clinical Practice Guideline (CPG) is designed to provide guidance to the deployed provider when they are treating a combat casualty who has sustained a spine or spinal cord injury. The CPG objective for the treatment and the movement of these patients is to maintain spinal stability through transport, perform decompression when urgently needed, achieve definitive stabilization when appropriate, avoid secondary injury, and prevent deterioration of the patient's neurological condition. Thorough and accurate documentation of the patient's neurological examination is crucial to ensure appropriate management decisions are made as the patient transits through the evacuation system. The use of this CPG should be in conjunction with good clinical judgment.
Nanophotonics in material-systems of large sizes (2015)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Soljacic, "Nanophotonics in material-systems of large sizes," in Advanced Photonics 2015, OSA Technical Digest (online) (Optica Publishing Group, 2015), paper NM2C.1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Probing local emission properties in InGaN/GaN quantum wells by scanning tunneling luminescence microscopy (2022)

Scanning tunneling electroluminescence microscopy is performed on a 3-nm-thick InGaN/GaN quantum well with x = 0.23 such that the main light emission occurs in the green. The technique is used to map the local recombination properties at a scale of ~10 nm and to correlate them with the surface topography imaged by scanning tunneling microscopy. A 500 nm x 500 nm area around a 150-nm large and 2.5-nm deep hexagonal defect is probed, revealing emission at higher energies close to the defect edges, a feature which is not visible in the macro-photoluminescence spectrum of the sample. Via a fitting of the local tunneling electroluminescence spectra, quantitative information on the fluctuations of the intensity, energy, width and phonon replica intensity of the different spectral contributions are obtained, revealing information about carrier localization in the quantum well. This procedure also indicates that carrier diffusion length on the probed part of the quantum well is approximately 40 nm.
E-beam inspection system for comparison of wafer and design data (2012)

Effectively patterning the intended design on the wafer for all possible geometries allowed by the design rule document is one of the most critical challenges for semiconductor manufacturing. Despite new lithography techniques like OPC, double patterning and the latest patterning simulation methods, and on-wafer evaluation using brightfield inspection and SEM review tools, patterning problems still occur and can result in a major delay in the qualification of a technology or product. Of particular concern are shorts and opens that cause product chip failure. Initial discovery of yield issues when a chip is being functionally tested is highly undesirable. A system for in-line, die to database (D2DB) comparison using E-beam inspection has been developed to address this risk. This system offers a substantial new line of defense against these patterning issues. The D2DB system is described along with a methodology for applying it for pattern fidelity inspection. Some examples illustrating the system operation are presented.
All-Optical Diode Suppressing Broadband Backward Transmission Using Single- and Four-Port Photonic Crystal Cavities (2018)

We present an all-optical diode suppressing broadband backward transmission using single-port and four-port photonic crystal (PC) cavities and its operation principle. We find that, by combining a four-port PC cavity and two power-dependent phase shifters that are composed by a 3-dB power divider and two single-port PC cavities, the backward transmission in the nonlinear-resonator-based all-optical diode becomes theoretically 0% for any input power and any input wavelength. To confirm the validity of our approach, the numerical analysis based on the nonlinear beam propagation method as well as the coupled mode theory is performed. The results prove that the forward transmission of -4 dB and large nonreciprocal transmission ratio of 35 dB are achievable.
Comparison of capacitive and frequential readout when scaling\n accelerometers down from Micro- to Nano- Electro Mechanical Systems (2012)

This paper shows the effect of scaling silicon accelerometers down from MEMS\nto NEMS. It models both electronics and Brownian noise sources for both\ncapacitive and resonant devices, and computes the minimum detectable signal\nattainable. Computed results are remarkably close to published experimental\nresults. It shows the relatively low influence of the quality factor and of the\nbeam width in the resonant case. Different scaling rules are investigated, and\nit appears that resonant sensing may satisfy some new application requirements,\nin particular for critical dimensions below a few hundreds of nm, when it is\nbetter resolved than capacitive sensing.\n
Longitudinal proteomic analysis of plasma from patients with severe COVID-19 reveal patient survival-associated signatures, tissue-specific cell death, and cell-cell interactions. (2021)

Mechanisms underlying severe COVID-19 disease remain poorly understood. We analyze several thousand plasma proteins longitudinally in 306 COVID-19 patients and 78 symptomatic controls, uncovering immune and non-immune proteins linked to COVID-19. Deconvolution of our plasma proteome data using published scRNAseq datasets reveals contributions from circulating immune and tissue cells. Sixteen percent of patients display reduced inflammation yet comparably poor outcomes. Comparison of patients who died to severely ill survivors identifies dynamic immune cell-derived and tissue-associated proteins associated with survival, including exocrine pancreatic proteases. Using derived tissue-specific and cell type-specific intracellular death signatures, cellular ACE2 expression, and our data, we infer whether organ damage resulted from direct or indirect effects of infection. We propose a model in which interactions among myeloid, epithelial, and T cells drive tissue damage. These datasets provide important insights and a rich resource for analysis of mechanisms of severe COVID-19 disease.