gebhart/patrepeval huggingface dataset:
Feasibility and accuracy of a robotic guidance system for navigated spine surgery in a hybrid operating room: a cadaver study (2020)

The combination of navigation and robotics in spine surgery has the potential to accurately identify and maintain bone entry position and planned trajectory. The goal of this study was to examine the feasibility, accuracy and efficacy of a new robot-guided system for semi-automated, minimally invasive, pedicle screw placement. A custom robotic arm was integrated into a hybrid operating room (OR) equipped with an augmented reality surgical navigation system (ARSN). The robot was mounted on the OR-table and used to assist in placing Jamshidi needles in 113 pedicles in four cadavers. The ARSN system was used for planning screw paths and directing the robot. The robot arm autonomously aligned with the planned screw trajectory, and the surgeon inserted the Jamshidi needle into the pedicle. Accuracy measurements were performed on verification cone beam computed tomographies with the planned paths superimposed. To provide a clinical grading according to the Gertzbein scale, pedicle screw diameters were simulated on the placed Jamshidi needles. A technical accuracy at bone entry point of 0.48 ± 0.44 mm and 0.68 ± 0.58 mm was achieved in the axial and sagittal views, respectively. The corresponding angular errors were 0.94 ± 0.83° and 0.87 ± 0.82°. The accuracy was statistically superior (p < 0.001) to ARSN without robotic assistance. Simulated pedicle screw grading resulted in a clinical accuracy of 100%. This study demonstrates that the use of a semi-automated surgical robot for pedicle screw placement provides an accuracy well above what is clinically acceptable.
A Tutorial on Anasazi and Belos. (2020)

Abstract not provided.
Diode-laser-pumped Er3+/Yb3+-doped fiber laser operating at 1.57 µm (1989)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text W. L. BARNES, D. J. TAYLOR, M. E. FERMANN, J. E. TOWNSEND, L. REEKIE, and D. N. PAYNE, "Diode-laser-pumped Er3+/Yb3+-doped fiber laser operating at 1.57 µm," in Optical Fiber Communication Conference, Vol. 5 of 1989 OSA Technical Digest Series (Optica Publishing Group, 1989), paper TUG4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Transparent Wood Biocomposite of Well-Dispersed Dye Content for Fluorescence and Lasing Applications (2023)

Aggregation-induced quenching often restricts emissive performance of optically active solid materials with embedded fluorescent dyes. Delignified and nanoporous wood readily adsorbs organic dyes and is investigated as a host material for rhodamine 6G (R6G). High concentration of R6G (>35 mM) is achieved in delignified wood without any ground-state dye aggregation. To evaluate emissive performance, a solid-state random dye laser is prepared using the dye-doped wood substrates. The performance in terms of lasing threshold and efficiency was improved with increased dye content due to the ability of delignified wood to disperse R6G.
Characterization of a Putative Pathogenicity Island from Bovine Staphylococcus aureus Encoding Multiple Superantigens (2001)

Previous studies have demonstrated that a proportion of Staphylococcus aureus isolates from bovine mastitis coproduce toxic shock syndrome toxin (TSST) and staphylococcal enterotoxin C (SEC). In this study, molecular genetic analysis of one such strain, RF122, revealed the presence of a 15,891-bp putative pathogenicity island (SaPIbov) encoding the genes for TSST (tst), the SEC bovine variant (sec-bovine), and a gene (sel) which encodes an enterotoxin-like protein. The island contains 21 open reading frames specifying hypothetical proteins longer than 60 amino acids including an integrase-like gene. The element is bordered by 74-bp direct repeats at the left and right junctions, and the integration site lies adjacent to the 3' end of the GMP synthase gene (gmps) in the S. aureus chromosome. SaPIbov contains a central region of sequence identity with the previously characterized tst pathogenicity island SaPI1 (J. A. Lindsay et al., Mol. Microbiol. 29:527-543, 1998). A closely related strain, RF120, of the same multilocus enzyme electrophoretic type, random amplified polymorphic DNA type, and ribotype, does not contain the island, implying that the element is mobile and that a recent insertion/deletion event has taken place. TSST and TSST/SEC-deficient mutants of S. aureus strain RF122 were constructed by allele replacement. In vitro bovine Vbeta-specific lymphocyte expansion analysis by culture supernatants of wild-type strains and of tst and sec-bovine allele replacement mutants revealed that TSST stimulates BTB13-specific T cells whereas SEC-bovine stimulates BTB93-specific T cells. This suggests that the presence of SaPIbov may contribute to modulation of the bovine immune response.
On-chip power supply noise measurement using Time Resolved Emission (TRE) waveforms of Light Emission from Off-State Leakage Current (LEOSLC) (2009)

In this paper, a new emission-based method for measuring the amplitude of on-chip power supply noise is presented. This technique uses Time Resolved Emission (TRE) waveforms of Light Emission from Off-State Leakage Current (LEOSLC) from CMOS gates, which are used as local probe points for the noise. In order to demonstrate the capabilities of this technique, we discuss the results obtained for two early microprocessor chips fabricated in 65 nm and 45 nm Silicon On Insulator (SOI) technologies.
Synthesis, Electronic Structure, and Ethylene Polymerization Activity of Bis(imino)pyridine Cobalt Alkyl Cations (2011)

Einkomponenten-Katalysatoren für die Ethylenpolymerisation stellen die im Titel bezeichneten Kationen aus Low-spin-CoII-Zentren und neutralen Bis(imino)pyridin-Chelatliganden dar (siehe Schema). Ihre Untersuchung gibt Einblick in die Mechanismen von Kettenwachstum und Katalysatordesaktivierung, die eine Folge der Bildung inaktiver kationischer Bis(imino)pyridin-Cobalt-Komplexe mit einem Diethylether-Ligand ist. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Microsensors and microbiosensors for retinal implants (2005)

This paper concentrates on recent developments in microsensors and microbiosensors for the possible applications in visual prostheses, especially retinal prosthetic devices. A brief introduction on the developments of visual prosthesis will be presented. The importance for in-vivo pH measurements as well as the need for an implantable pH sensor will be demonstrated. Electrochemical biosensors developed for sensitive measurements of glucose and L-glutamate, a known neurotransmitter in the retina and brain will be reviewed. Novel electrode materials such as chemically modified thin-film diamond in applications for implantable biosensors will be shown. The challenges in the development of chronic implantable sensor systems, especially using MEMS technology for medical implants, will be discussed.
A variational principle for computing nonequilibrium fluxes and\n potentials in genome-scale biochemical networks (2011)

We derive a convex optimization problem on a steady-state nonequilibrium\nnetwork of biochemical reactions, with the property that energy conservation\nand the second law of thermodynamics both hold at the problem solution. This\nsuggests a new variational principle for biochemical networks that can be\nimplemented in a computationally tractable manner. We derive the Lagrange dual\nof the optimization problem and use strong duality to demonstrate that a\nbiochemical analogue of Tellegen's theorem holds at optimality. Each optimal\nflux is dependent on a free parameter that we relate to an elementary kinetic\nparameter when mass action kinetics is assumed.\n
Treatment of Heavy, Long-Chain Petroleum-Hydrocarbon Impacted Soils Using Chemical Oxidation (2016)

Chemical oxidation is a promising approach for in situ or ex situ treatment of heavy, long-chain (C12−C40) petroleum-hydrocarbon impacted soils. Aqueous chemical oxidation treatments (sodium percarbonate, hydrogen peroxide, sodium persulfate, chlorine dioxide, sodium permanganate, and ozone) using two oxidant concentrations were tested in batch tests on soils containing C12–C40 total petroleum hydrocarbon (TPH) concentrations of 1.6 and 2.0% weight/weight (w/w) resulting in TPH reductions from 20 to 90%. Gas chromatography with flame ionization detector (GC-FID) chromatograms for hydrocarbons were obtained and presented as chain-length fractions. Sodium percarbonate and hydrogen peroxide achieved the highest TPH reduction. There was little difference between 1 and 10% weight/volume (w/v) for all oxidant doses on TPH removal. Soluble organics in the liquid supernatants after oxidation of the TPH-containing soils were characterized by TPH analysis and excitation-emission matrix fluorescence spectroscopy. Benchmark Soil 1 (BM1) containing 1.6% w/w TPH was more susceptible to solubilization than Benchmark Soil 2 (BM2, containing 2.0% w/w TPH) according to TPH removal data and posttreatment supernatant quality. Some of the oxidants achieving the greater reduction in soil TPH resulted in higher aqueous phase organic content, based upon TPH measurements and fluorescence spectroscopy. Persulfate achieved intermediate TPH reduction in soil, but the separated aqueous phase had lower carbon content. This work showed chemical oxidation can transform and mobilize heavy hydrocarbons in soil and can produce more water-soluble organics. Chemical oxidation alone may achieve regulated TPH soil concentration, or it could also be used in conjunction with other technologies such as bioremediation or surfactant washing to further reduce TPH in soil.
Medullary Thyroid Carcinoma with Ectopic Adrenocorticotropic Hormone Syndrome (2014)

Ectopic adrenocorticotropic hormone (ACTH) syndrome is caused most frequently by a bronchial carcinoid tumor or by small cell lung cancer. Medullary thyroid carcinoma (MTC) is a rare etiology of ectopic ACTH syndrome. We describe a case of Cushing syndrome due to ectopic ACTH production from MTC in a 48-year-old male. He was diagnosed with MTC 14 years ago and underwent total thyroidectomy, cervical lymph node dissection and a series of metastasectomies. MTC was confirmed by the pathological examination of the thyroid and metastatic mediastinal lymph node tissues. Two years after his last surgery, he developed Cushingoid features, such as moon face and central obesity, accompanied by uncontrolled hypertension and new-onset diabetes. The laboratory results were compatible with ectopic ACTH syndrome. A bilateral adrenalectomy improved the clinical and laboratory findings that were associated with Cushing syndrome. This is the first confirmed case of ectopic ACTH syndrome caused by MTC in Korea.
Regulation of CD4-p561ck-associated phosphatidylinositol 3-kinase (PI 3-kinase) and phosphatidylinositol 4-kinase (PI 4-kinase) (1993)

CD4 serves as a receptor for MHC class II antigens and as a receptor for the human immunodeficiency virus (HIV-1) viral coat protein gp120. It is coupled to the protein-tyrosine kinase p56lck, an interaction necessary for an optimal response of certain T cells to antigen. Although anti-CD4 crosslinking may increase lck activity, the effects of HIV-1 gp120 have been controversial. Activated protein-tyrosine kinases are known to associate with certain intracellular proteins possessing src-homology regions (SH-2 domains) such as phosphatidylinositol 3-kinase (PI 3-kinase). In this paper, we demonstrate that the CD4:p56lck complex associates with significant amounts of phosphatidylinositol (PI) kinase activity. High pressure liquid chromatographic (HPLC) analysis of the reaction products demonstrated the presence of phosphatidylinositol 3-phosphate (PI 3-P) and phosphatidylinositol 4-phosphate (PI 4-P), thus indicating that PI 3 and PI 4 kinases associate with CD4-p56lck. The p85 subunit of PI 3-kinase was also detected in anti-CD4 immunoprecipitates by immunoblotting with anti-p85 antiserum. Significantly, p56lck binding to CD4 appears to be necessary for the detection of lipid kinase activity associated with p56lck. Also, anti-HIV gp120 and anti-CD4 crosslinking induced a 10-15-fold increase in levels of both PI 3- and PI 4-kinase activity in anti-CD4 precipitates. Stimulation of CD4-p56lck-linked PI kinases by crosslinked HIV-1 gp120 may play a role in HIV-1-induced immune defects.
Aerosol Treatment of Cystic Fibrosis (2003)

Different aerosol therapies have been employed to treat the underlying cause and symptoms of cystic fibrosis (CF) during the past two decades. A summary of the main elements of the disease and aerosol treatments employed in clinical care and experimental trials are presented. Methods of aerosol generation and characterization are reviewed. Suggestions for improving the current treatments are provided.
P121 <break /> MMP-7 is a predictive biomarker of disease progression in patients with early diagnosis of Idiopathic Pulmonary Fibrosis. (2016)

The heterogeneity of disease progression in the IPF patient population poses significant obstacles to offer optimal patient care and prevents efficient development of novel therapeutic interventions. Disease-relevant biomarkers could enable more accurate prognostication, as well as patient stratification for drug development and personalized …
Heterogeneity of Porphyromonas gingivalis strains in the induction of alveolar bone loss in mice (2000)

These experiments examine alveolar bone loss in a model in which specific pathogen-free mice are exposed orally with Porphyromonas gingivalis. Alveolar bone loss was induced as a result of a specific infection with P. gingivalis, rather than other environmental antigens. Infection with live P. gingivalis was required, as significant bone loss did not follow gavage with formalin-killed P. gingivalis. The virulence of different strains of P. gingivalis was compared. Two laboratory strains of the bacteria (ATCC 53977 and W50) and a mutant strain lacking the 43-kDa fimbrillin (strain DPG3) induced bone loss. P. gingivalis 381, however, did not induce bone loss. There was a strong immunoglobulin G (IgG) antibody response to infection with each strain but a significant serum IgA response only to strain 381. These studies show that in mice with a background oral microflora bone loss is induced by a specific infection with P. gingivalis and that bacterial strain variation is important in determining whether alveolar bone loss will ensue.
Rapid application and removal of second messengers to cyclic nucleotide-gated channels from olfactory epithelium. (1993)

The last step in the second-messenger cascade mediating vertebrate olfactory transduction is the direct opening of a nonspecific cation channel by cAMP. The kinetic properties of this interaction are critical in determining the time course of the sensory response. To analyze these properties, excised inside-out membrane patches containing either the native channel from salamander olfactory-receptor neurons or a recombinant rat olfactory cyclic nucleotide-gated channel were exposed to short pulses of known concentrations of cAMP or cGMP to mimic a rapid and transient production of second messenger. Channel activity outlasted cyclic nucleotide pulses for several hundred milliseconds. This effect was due to an intrinsic property of the olfactory channel protein because it did not occur with cGMP-activated channels from retinal photoreceptors. Gating kinetics of the olfactory channel were both voltage and agonist dependent. These results demonstrate that the overall slow channel-gating kinetics could account for the difference in time course between the odor-induced changes in cAMP concentration and the subsequent sensory generator current.
Regulation of CD3-induced phospholipase C-gamma 1 (PLC gamma 1) tyrosine phosphorylation by CD4 and CD45 receptors. (1992)

Stimulation of the signal transduction cascade in T cells through the T-cell receptor (CD3) coincides with activation of the phosphatidylinositol-phospholipase C (PI-PLC) pathway. activation of phospholipase C-gamma 1 (PLC gamma 1) occurs through tyrosine phosphorylation in T cells following surface ligation of CD3 receptors with CD3-specific monoclonal antibodies (mAb). Here we show that cross-linking of CD4 molecules with CD3 augments the tyrosine phosphorylation of PLC gamma 1, while co-ligation of CD3 with CD45 (a receptor tyrosine phosphatase) results in reduced PLC gamma 1 tyrosine phosphorylation. Mobilization of intracellular calcium correlated with the extent of PLC gamma 1 tyrosine phosphorylation, indicating that PLC gamma 1 enzymatic activity in T cells may be regulated by its phosphorylation state. The time-course of PLC gamma 1 tyrosine phosphorylation in cells stimulated by soluble anti-CD3 was transient and closely paralleled that of calcium mobilization, while the kinetics in cells stimulated by immobilized anti-CD3 were prolonged. The PI-PLC pathway in T cells was not stimulated by tyrosine phosphorylation of PLC gamma 2, a homologue of PLC gamma 1, demonstrating the strict regulation of PLC gamma isoform usage in CD3-stimulated T cells. A 35,000/36,000 MW tyrosine phosphorylated protein in T cells formed stable complexes with PLC gamma 1, and its tyrosine phosphorylation was co-regulated with that of PLC gamma 1 by CD4 and CD45 receptors. Enzymatic activation and tyrosine phosphorylation of PLC gamma 1 occurs during growth factor stimulation of fibroblasts, where PLC gamma 1 exists in multi-component complexes. The observation that PLC gamma 1 exists in complexes with unique tyrosine phosphorylated proteins in T cells suggests that haematopoietic lineage-specific proteins associated with PLC gamma 1 may play roles in cellular signalling.
Nanocrystal-based hybrid white light generation with tunable colour parameters (2007)

We present the hybridization of CdSe/ZnS core-shell nanocrystals (NCs) on InGaN/GaN based blue/near-UV LEDs to generate light widely tunable across the visible spectral range and especially within the white region of the CIE (1931) chromaticity diagram. We report on the design, growth, fabrication and characterization of these hybrid NC-LEDs. In 26 NC-LED samples, we experimentally show the effect of the NC concentration and NC film thickness on tuning the colour properties of the generated light (tristimulus coordinates, colour rendering index and correlated temperature) and further compare layer by layer assembly and blending of NCs for integration in LEDs. With greatly tunable colour properties, these hybrid white light sources hold promise for future lighting and display applications.
Polymeric Nanocomposites for Automotive Applications (2000)

New nanocomposites are currently being developed that have real industrial potential—loading a polymer with a small (ca. 5 %) amount of inorganic nanoparticles (the Figure shows a polypropylene–clay hybrid composite) is expected to give rise to significant improvement to the materials properties with only a minor increase in cost. Recent developments in this area are summarized here.
Cascadable laser logic devices: discrete integration of phototransistors with surface-emitting laser diodes (1991)

A new class of cascadable optical logic devices is described which consists of integrated GaAs/AlGaAs phototransistors and surface-emitting lasers. The devices function as optical neurons (‘smart pixels’), have high optical gain (a factor of &gt;20 overall, &gt;200 differential), very high on/off contrast (&gt;2700, 34dB) and are ideal for neural networks and optical computing applications.
A Pipeline for Automating Labeling to Prediction in Classification of NFRs (2021)

Non-Functional Requirements (NFRs) focus on the operational constraints of the software system. Early detection of NFRs enables their incorporation into the architectural design at an initial stage, a practice obviously preferable to expensive refactoring at a later stage. Automated identification and classification of NFRs has therefore seen numerous efforts using rule-based, machine learning and deep learning-based approaches. One of the major challenges for such an automation is the manual effort that needs to be invested into labeling of training data. This is a concern for large software vendors who typically work on a variety of applications in diverse domains. We address this challenge by designing a pipeline that facilitates classification of NFRs using only a limited amount (~ 20% of an available new dataset) of labeled data for training. We (1) employed Snorkel to automatically label a dataset comprising NFRs from various Software Requirement Specification documents, (2) trained several classifiers using it, and (3) reused these pre-trained classifiers using a Transfer Learning approach to classify NFRs in industry-specific datasets. From among the various language model classifiers, the best results have been obtained for a BERT based classifier fine-tuned to learn the linguistic intricacies of three different domain-specific datasets from real-life projects.
Sequential Priming with Simian Immunodeficiency Virus (SIV) DNA Vaccines, with or without Encoded Cytokines, and a Replicating Adenovirus-SIV Recombinant Followed by Protein Boosting Does Not Control a Pathogenic SIVmac251Mucosal Challenge (2008)

Previously, combination DNA/nonreplicating adenovirus (Ad)- or poxvirus-vectored vaccines have strongly protected against SHIV(89.6P), DNAs expressing cytokines have modulated immunity elicited by DNA vaccines, and replication-competent Ad-recombinant priming and protein boosting has strongly protected against simian immunodeficiency virus (SIV) challenge. Here we evaluated a vaccine strategy composed of these promising components. Seven rhesus macaques per group were primed twice with multigenic SIV plasmid DNA with or without interleukin-12 (IL-12) DNA or IL-15 DNA. After a multigenic replicating Ad-SIV immunization, all groups received two booster immunizations with SIV gp140 and SIV Nef protein. Four control macaques received control DNA plasmids, empty Ad vector, and adjuvant. All vaccine components were immunogenic, but the cytokine DNAs had little effect. Macaques that received IL-15-DNA exhibited higher peak anti-Nef titers, a more rapid anti-Nef anamnestic response postchallenge, and expanded CD8(CM) T cells 2 weeks postchallenge compared to the DNA-only group. Other immune responses were indistinguishable between groups. Overall, no protection against intrarectal challenge with SIV(mac251) was observed, although immunized non-Mamu-A*01 macaques as a group exhibited a statistically significant 1-log decline in acute viremia compared to non-Mamu-A*01 controls. Possible factors contributing to the poor outcome include administration of cytokine DNAs to sites different from the Ad recombinants (intramuscular and intratracheal, respectively), too few DNA priming immunizations, a suboptimal DNA delivery method, failure to ensure delivery of SIV and cytokine plasmids to the same cell, and instability and short half-life of the IL-15 component. Future experiments should address these issues to determine if this combination approach is able to control a virulent SIV challenge.