gebhart/patrepeval huggingface dataset:
XDBus: a high-performance, consistent, packet-switched VLSI bus (2002)

The XDBus is a low-cost, synchronous, packet-switched VLSI bus designed for use in high-performance multiprocessors. The bus provides an efficient coherency protocol which guarantees processors a consistent view of memory in the presence of caches and IO. Low-voltage swing (GTL) CMOS drivers connected to balanced transmission line traces ensure low power as well as high speed for chip, board, and as backplane applications. The signaling scheme and coherency protocol work together to promote a high level of system integration, while permitting a wide variety of configurations to be realized. These configurations include small single board systems, multiple bus systems, multiboard backplane systems, and multilevel cache systems. The bus is used in several commercial systems including Sun Microsystem's new SPARCcenter 2000 series.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Monoclinic Paracetamol vs. Paracetamol-4,4′-Bipyridine Co-Crystal; What Is the Difference? A Charge Density Study (2018)

Paracetamol (PCM) has two well-documented polymorphic forms at room temperature; monoclinic Form I is more stable than the other orthorhombic Form II. Form II exhibits improved tabletting properties compared to Form I due to low shearing forces; however, difficulties in its manufacture have limited its use in industrial manufacture. Previous studies have found that the introduction of a co-former to form co-crystals would allow the PCM molecule to exist in a conformation similar to that of the orthorhombic form while being more stable at room temperature. Experimental charge density analysis of the paracetamol-4,4′-bipyridine (PCM-44BP) co-crystal system, and its constituent molecules, has been carried out to examine the forces that drive the formation and stabilisation of the co-crystal, while allowing PCM to maintain a packing motif similar to that found in Form II. It is hoped studies on this well-known compound will help apply the knowledge gained to other drug molecules that are less successful. The PCM molecules in the co-crystal were found to exhibit similar packing motifs to that found in Form I, however, intercalation of the 44BP molecule between the PCM layers resulted in a shallower angle between molecular planes, which could result in the required lateral shear. Topological analysis identified more weak interactions in the co-crystal compared to the individual molecules, thus allowing for greater stability as evidenced by the lattice energies. Weak interactions in the PCM-44BP co-crystal were found to range in strength from 4.08–84.33 kJ mol−1, and this variety allowed the PCM-44BP planes to be held together, while a weak π–π interaction (15.14 kJ mol−1) allowed lateral shear to occur, thus mimicking the planes found in Form II PCM and offering the possibility of improved tabletting properties. A comparison of integrated atomic charges between partitions of the PCM molecules in the single and co-crystal found that the hydroxyl and amide groups were involved in greater hydrogen bonding in the co-crystal, resulting in a charge redistribution across the molecule evidenced by a larger molecular dipole moment (µ = 12.34D). These findings, in addition to the co-crystal having the largest lattice energy, form a potential basis with which to predict that the co-crystal exhibits improved solubility and stability profiles. It is anticipated that these findings will contribute to improvements in the formulation and other physical properties of PCM and other pharmaceutical compounds.
Compositional sensory and biological evaluations of supplemented pea moin moin (1987)

Essai d'evaluation de l'efficacite d'une supplementation de ce plat traditionnel africain ; la complementation en proteines et acides amines soufres est realisee par des graines de melon ou de courge et/ou du poisson. La complementation optimale, du point de vue chimique, organoleptique et physiologique (chez le rat) consiste en 20 % de graines de melon ou courge et 10 % de farine de poisson
Autoimmunity and effector recognition in Arabidopsis thaliana can be uncoupled by mutations in the RRS1‐R immune receptor (2018)

Plant nucleotide-binding leucine-rich repeat (NLR) disease resistance proteins recognize specific pathogen effectors and activate a cellular defense program. In Arabidopsis thaliana (Arabidopsis), Resistance to Ralstonia solanacearum 1 (RRS1-R) and Resistance to Pseudomonas syringae 4 (RPS4) function together to recognize the unrelated bacterial effectors PopP2 and AvrRps4. In the plant cell nucleus, the RRS1-R/RPS4 complex binds to and signals the presence of AvrRps4 or PopP2. The exact mechanism underlying NLR signaling and immunity activation remains to be elucidated. Using genetic and biochemical approaches, we characterized the intragenic suppressors of sensitive to low humidity 1 (slh1), a temperature-sensitive autoimmune allele of RRS1-R. Our analyses identified five amino acid residues that contribute to RRS1-R<sup>SLH</sup><sup>1</sup> autoactivity. We investigated the role of these residues in the RRS1-R allele by genetic complementation, and found that C15 in the Toll/interleukin-1 receptor (TIR) domain and L816 in the LRR domain were also important for effector recognition. Further characterization of the intragenic suppressive mutations located in the RRS1-R TIR domain revealed differing requirements for RRS1-R/RPS4-dependent autoimmunity and effector-triggered immunity. Our results provide novel information about the mechanisms which, in turn, hold an NLR protein complex inactive and allow adequate activation in the presence of pathogens.
Development of 2.5D and 3D IC Fabrication and Assembly Technologies (2015)

2.5D/3D IC assembly is where the traditional foundry and assembly house model breaks down. The greatly reduced feature sizes of microbumps in combination with very large, thin interposers and ICs present many challenges for assembly. With densely integrated packages and stacked thin dies, warpage at various steps of assembly process can lead to die crack, weak or open interconnection, and delamination. Microbump die with copper pillar and solder cap lacks the flexibility of conventional BGA solder balls in warpage compensation. Low temperature dielectric materials for interposer backside passivation lack chemical, thermal stability and mechanical strength compared to similar materials cured at higher temperatures. Ultra- low stand-off between dies creates new challenge for flux residue removal and underfill processing, adhesion and reliability. In this paper, we present learning and results from building two Invensas 2.5D interposer test vehicles with rectangular (19mmx27mm) and square (24mmx24 mm) silicon interposers. Since the industry is still debating where the MEOL processes will take place, these two test vehicles use both assembly centric and fab centric flows. We conducted comprehensive material and process compatibility studies to meet our goal of process capability and product reliability. We explored three different interposer fabrication/ assembly flows that includes copper-to-copper bonding as well as solder capped copper pillar microbumps for microbump die to interposer connection. We optimized the interposer fabrication process to improve interposer quality and warpage. We instituted 100% bump inspection and tight control on microbump die quality and co-planarity to improve assembly yield. We developed robust soldering and cleaning processes to achieve high soldering process yield. We evaluated several methods of flux clean and developed a procedure to achieve optimal flux residue removal without causing mechanical damage to solder joints. We explored vacuum and pressure curing process for underfill and adopted advance underfill cure technology to eliminate voids in underfill. The impact of these factors on assembly yield and reliability will be presented.
Functional volumes modeling: Scaling for group size in averaged images (1999)

Functional volumes modeling (FVM) is a statistical construct for metanalytic modeling of the locations of brain functional areas as spatial probability distributions. FV models have a variety of applications, in particular, to serve as spatially explicit predictions of the Talairach-space locations of functional activations, thereby allowing voxel-based analyses to be hypothesis testing rather than hypothesis generating. As image averaging is often applied in the analysis of functional images, an important feature of FVM is that a model can be scaled to accommodate any degree of intersubject image averaging in the data set to which the model is applied. In this report, the group-size scaling properties of FVM were tested. This was done by: (1) scaling a previously constructed FV model of the mouth representation of primary motor cortex (M1-mouth) to accommodate various degrees of averaging (number of subjects per image = n = 1, 2, 5, 10), and (2) comparing FVM-predicted spatial probability contours to location-distributions observed in averaged images of varying n composed from randomly sampling a 30-subject validation data set.
Age and founder effect of SOD1 A4V mutation causing ALS (2009)

North American SOD1 alanine to valine mutation at codon 4 descended from two founders (Amerindian and European) 400-500 years ago.
ChemInform Abstract: Iron‐Catalyzed Cross‐Coupling of 1‐Alkynylcyclopropyl Tosylates and Related Substrates. (2016)

Abstract The first examples of iron catalyzed cross‐coupling reactions of tertiary alkynyl or alkenyl substituted cyclopropyl tosylates with alkyl Grignard reagents are reported.
A subcellular model of glucose-stimulated pancreatic insulin secretion (2008)

When glucose is raised from a basal to stimulating level, the pancreatic islets respond with a typical biphasic insulin secretion pattern. Moreover, the pancreas is able to recognize the rate of change of the glucose concentration. We present a relatively simple model of insulin secretion from pancreatic beta-cells, yet founded on solid physiological grounds and capable of reproducing a series of secretion patterns from perfused pancreases as well as from stimulated islets. The model includes the notion of distinct pools of granules as well as mechanisms such as mobilization, priming, exocytosis and kiss-and-run. Based on experimental data, we suggest that the individual beta-cells activate at different glucose concentrations. The model reproduces most of the data it was tested against very well, and can therefore serve as a general model of glucose-stimulated insulin secretion. Simulations predict that the effect of an increased frequency of kiss-and-run exocytotic events is a reduction in insulin secretion without modification of the qualitative pattern. Our model also appears to be the first physiology-based one to reproduce the staircase experiment, which underlies 'derivative control', i.e. the pancreatic capacity of measuring the rate of change of the glucose concentration.
Optimizing the directivity of piezoelectric matrix transducer elements mounted on an ASIC (2017)

Over the last decade, clinical studies show a strong interest in real-time 3D imaging. This calls for ultrasound probes with high-element-count 2D matrix transducer arrays. These may be interfaced to an imaging system using an in-probe Application Specific Integrated Circuit (ASIC) that takes care of signal amplification, element switching, sub-array beamforming, etc. Since the ASIC is made from silicon and is mounted directly behind the transducer elements, it can acoustically be regarded as a rigid plate that can sustain traveling lateral waves. These waves lead to acoustical cross-talk between the elements, and results in extra peaks in the directivity pattern. We propose two solutions to this problem, based on numerical simulations. One approach is to decrease the phase velocity in the silicon by reducing the silicon thickness and absorbing the energy using a proper backing material. Another solution is to disturb the waves inside the silicon plate by sub-dicing the back-side of the ASIC. We conclude that both solutions can be used to improve the directivity pattern.
Future Applications of SEED Methodology (2015)

A SEED model set (SEED 3.0) can cover a large portion of hard and soft failures responsible for typical design fixes on the PCB board or the IC. The goal of a comprehensive verification of the system design is to provide design guidance for an efficient and effective electrostatic discharge (ESD) protection addressing the various failure mechanisms. To apply the full SEED analysis, a simulation of the interference pulse needs to be performed. An accurate simulation of the pulse waveform is very difficult, if not impossible. These limitations in turn require sophisticated modeling methods. While these challenges continue, the advances in technology also make it important to understand the limitations that might arise from the demands for high-speed interfaces. Further, the increased applications and other developing technology areas warrant an overview of these developments and what these might mean for future system level ESD protection challenges.
Low‐Voltage Self‐Assembled Monolayer Field‐Effect Transistors on Flexible Substrates (2013)

Self-assembled monolayer field-effect transistors (SAMFETs) of BTBT functionalized phosphonic acids are fabricated. The molecular design enables device operation with charge carrier mobilities up to 10(-2) cm(2) V(-1) s(-1) and for the first time SAMFETs which operate on rough, flexible PEN substrates even under mechanical substrate bending.
Mechanochemical Mediated Coexistence of B←N Coordination and Hydrogen Bonding (2023)

Abstract Mechanochemistry afforded a photoactive cocrystal via coexisting (B)O−H⋅⋅⋅N hydrogen bonds and B←N coordination. Specifically, solvent‐free mechanochemical ball mill grinding and liquid‐assisted grinding of a boronic acid and an alkene resulted in mixtures of hydrogen‐bonded and coordinated complexes akin to mixtures of noncovalent complexes that can be obtained in solution in equilibria processes. The alkenes of the hydrogen‐bonded assembly undergo an intermolecular [2+2] photodimerization in quantitative conversion, effectively reporting the outcome of the self‐assembly processes. Our results suggest that interplay involving noncovalent bonds subjected to mechanochemical conditions can lead to functional solids where, in the current case, the structure composed of the weaker hydrogen bonding interactions predominates.
Impact of Cytokines on Replication in the Thymus of Primary Human Immunodeficiency Virus Type 1 Isolates from Infants (2002)

Early infection of the thymus with the human immunodeficiency virus (HIV) may explain the more rapid disease progression among children infected in utero than in children infected intrapartum. Therefore, we analyzed infection of thymocytes in vitro by HIV type 1 primary isolates, obtained at or near birth, from 10 children with different disease outcomes. HIV isolates able to replicate in the thymus and impact thymopoiesis were present in all infants, regardless of the timing of viral transmission and the rate of disease progression. Isolates from newborns utilized CCR5, CXCR4, or both chemokine receptors to enter thymocytes. Viral expression was observed in discrete thymocyte subsets postinfection with HIV isolates using CXCR4 (X4) and isolates using CCR5 (R5), despite the wider distribution of CXCR4 in the thymus. In contrast to previous findings, the X4 primary isolates were not more cytopathic for thymocytes than were the R5 isolates. The cytokines interleukin-2 (IL-2), IL-4, and IL-7 increased HIV replication in the thymus by inducing differentiation and expansion of mature CD27(+) thymocytes expressing CXCR4 or CCR5. IL-2 and IL-4 together increased expression of CXCR4 and CCR5 in this population, whereas IL-4 and IL-7 increased CXCR4 but not CCR5 expression. IL-2 plus IL-4 increased the viral production of all pediatric isolates, but IL-4 and IL-7 had a significantly higher impact on the replication of X4 isolates compared to R5 isolates. Our studies suggest that coreceptor use by HIV primary isolates is important but is not the sole determinant of HIV pathogenesis in the thymus.
Alanine series of ovine corticotropin releasing factor (oCRF): a structure-activity relationship study (1992)

Previous structure-activity relationship studies of CRF have shown that residues 1-4 were not necessary for receptor binding or transduction, that residues 4-8 were important for activation, and that residues 12-41 were mostly responsible for binding. Finally it was proposed that CRF assumed an alpha-helical structure when interacting with its receptor. By systematic substitution of each residue (except residues 1-4) in ovine CRF (oCRF) by Ala, we have investigated the role played by individual side chains in receptor recognition and activation. Out of 33 analogues (synthesized using SPPS on an MBHA resin, purified by RPHPLC and characterized by amino acid and mass spectral analyses), a significant loss of biological potency (less than 1% potency of native) was observed for 6 analogues ([Ala6], [Ala8], [Ala10], [Ala12], [Ala14], and [Ala38]); 12 analogues had biological potencies ranging from 1% to 60% and ranked as follows: [Ala35] less than [Ala16] less than [Ala9] less than [Ala19] less than [Ala15] less than [Ala13] less than [Ala7] less than [Ala23] less than [Ala11] less than or equal to [Ala21] less than [Ala27] less than or equal to [Ala18]; 8 analogues were found to be equipotent (greater than 60% and less than 150%) ([Ala5], [Ala17], [Ala26], [Ala29], [Ala30], [Ala34], [Ala36], and [Ala37]; and 7 analogues were found to be approximately 2-5 times more potent than native oCRF ([Ala25] = [Ala40] less than or equal to [Ala39] less than or equal to [Ala33] less than [Ala20] less than [Ala22] less than [Ala32], in an in vitro pituitary cell culture assay. In summary, the Ala substitutions which showed the greatest loss of potency (less than 1% of native oCRF) were those replacing hydrophobic residues while those showing the greatest increase in potency were replacing hydrophilic residues. Of the 22 Ala-containing analogues in the C-terminal half of the molecule, 17 analogues have equal or greater potencies than native oCRF. Substitution of Ala in the N-terminal region (residues 5-19) on the other hand is generally detrimental to biological activity. These results suggest that the side chains of residues 5-19 are very important for receptor binding and activation while, in the C-terminal region, the amino acid side chains may be more responsible for structural conservation than for functional expression.
Hybrid core-shell particles for mRNA systemic delivery (2022)

mRNA based infectious disease vaccines have opened the venue for development of novel nucleic acids-based therapeutics. For all mRNA therapeutics dedicated delivery systems are required, where different functionalities and targeting abilities need to be optimized for the respective applications. One option for advanced formulations with tailored properties are lipid-polymer hybrid nanoparticles with complex nanostructure, which allow to combine features of several already well described nucleic acid delivery systems. Here, we explored hyaluronic acid (HA) as coating of liposome-mRNA complexes (LRCs) to investigate effects of the coating on surface charge, physicochemical characteristics and biological activity. HA was electrostatically attached to positively charged complexes, forming hybrid LRCs (HLRCs). At different N/P ratios, physico-chemical characterization of the two sets of particles showed similarity in size (around 200 nm) and mRNA binding abilities, while the presence of the HA shell conferred a negative surface charge to otherwise positive complexes. High transfection efficiency of LRCs and HLRCs in vitro has been obtained in THP-1 and human monocytes derived from PBMC, an interesting target cell population for cancer and immune related pathologies. In mice, quantitative biodistribution of radiolabeled LRC and HLRC particles, coupled with bioluminescence studies to detect the protein translation sites, hinted towards both particles' accumulation in the hepatic reticuloendothelial system (RES). mRNA translated proteins though was found mainly in the spleen, a major source for immune cells, with preference for expression in macrophages. The results showed that surface modifications of liposome-mRNA complexes can be used to fine-tune nanoparticle physico-chemical characteristics. This provides a tool for assembly of stable and optimized nanoparticles, which are prerequisite for future therapeutic interventions using mRNA-based nanomedicines.
Syntax Matters! Syntax-Controlled in Text Style Transfer (2021)

Existing text style transfer (TST) methods rely on style classifiers to disentangle the text's content and style attributes for text style transfer. While the style classifier plays a critical role in existing TST methods, there is no known investigation on its effect on the TST methods. In this paper, we conduct an empirical study on the limitations of the style classifiers used in existing TST methods. We demonstrate that the existing style classifiers cannot learn sentence syntax effectively and ultimately worsen existing TST models' performance. To address this issue, we propose a novel Syntax-Aware Controllable Generation (SACG) model, which includes a syntaxaware style classifier that ensures learned style latent representations effectively capture the syntax information for TST. Through extensive experiments on two popular TST tasks, we show that our proposed method significantly outperforms the state-of-the-art methods. Our case studies have also demonstrated SACG's ability to generate fluent target-style sentences that preserved the original content.
A consideration on electrical characteristics of high power SIThs [thyristors] (2002)

The characteristics of high power static induction thyristors have been analyzed and SIThs were fabricated using a segment structure. In the segment structure, it was found that the low ranch gate resistance is effective for weakening the current crowding during turn-off. As a result, 4.5 kV-1 kA SIThs from 70 mm /spl phi/ pellets have been made on an experimental basis and evaluated.
Training With Temporally Modified Speech Results In Dramatic Improvements In Speech Perception And Language Comprehension (1995)

Tallal & colleagues have shown that children with developmental language-based learning disabilities (LLD) require significantly longer intervals between two or more sensory events to discriminate or sequence them accurately. Further, they have shown that these children fail to discriminate between speech syllables that incorporate brief or rapidly changing acoustic cues that are followed in rapid succession by other acoustic cues (such as the formant transitions in stop-consonants). However, significant improvement in syllable discrimination was found when the duration of the formant transitions within stop-consonant syllables were computer extended from 40 to 80 ms.
Optical nano-hairs for micro-optical applications (2013)

The paper introduces optical nano-hair structures made from high-κ dielectrics that can be used to impart an arbitrary phase function to the transmitted beam. The concept behind the design of these new structures is elaborated.
7-Azido-N,N-diethyl-4,5-O-isopropylidene-4-C-methyl-3,6-anhydro-7-deoxy-D-glycero-D-manno-heptonamide (2009)

The reaction of 5-azido-5-de-oxy-2,3-O-isopropyl-idene-2-C-methyl-d-ribose with N,N-diethyl-2-(dimethyl-sulfuranyl-idene)acetamide gave the title compound, C(15)H(26)N(4)O(5), as the major product arising from initial formation of an epoxide which was subsequently opened by intra-molecular attack of the free 4-hydroxyl group. X-ray crystallography confirmed the relative stereochemistry of the title compound and the absolute configuration was determined by the use of d-ribose as the starting material. The crystal structure contains chains of mol-ecules running parallel to the a axis, being linked by weak bifurcated O-H⋯(N,N) hydrogen bonds.