gebhart/patrepeval huggingface dataset:
Q-Tof ESI-MS/MS and automated software interpretation for de novo sequencing of tryptic peptides from gel separated proteins (2000)

Conference Abstract| October 01 2000 Q-Tof ESI-MS/MS and automated software interpretation for de novo sequencing of tryptic peptides from gel separated proteins D. Gostick; D. Gostick 1Micromass UK Ltd, Wythemhawe, Manchester, M23 9LZ, UK Search for other works by this author on: This Site PubMed Google Scholar J. Langridge; J. Langridge 1Micromass UK Ltd, Wythemhawe, Manchester, M23 9LZ, UK Search for other works by this author on: This Site PubMed Google Scholar R. Rachubinski; R. Rachubinski 2University of Alberta, Dept of Cell Biology, Edmonton, Canada, T6G 2HZ. 3MaxEnt Solutions, Cambridge CB3 7HJ, UK Search for other works by this author on: This Site PubMed Google Scholar R. Wozniak; R. Wozniak 2University of Alberta, Dept of Cell Biology, Edmonton, Canada, T6G 2HZ. 3MaxEnt Solutions, Cambridge CB3 7HJ, UK Search for other works by this author on: This Site PubMed Google Scholar J. Smith; J. Smith 2University of Alberta, Dept of Cell Biology, Edmonton, Canada, T6G 2HZ. 3MaxEnt Solutions, Cambridge CB3 7HJ, UK Search for other works by this author on: This Site PubMed Google Scholar J. Cottrell; J. Cottrell 1Micromass UK Ltd, Wythemhawe, Manchester, M23 9LZ, UK Search for other works by this author on: This Site PubMed Google Scholar J. Hoyes; J. Hoyes 1Micromass UK Ltd, Wythemhawe, Manchester, M23 9LZ, UK Search for other works by this author on: This Site PubMed Google Scholar E. Kapp; E. Kapp 1Micromass UK Ltd, Wythemhawe, Manchester, M23 9LZ, UK Search for other works by this author on: This Site PubMed Google Scholar J. Skilling; J. Skilling 2University of Alberta, Dept of Cell Biology, Edmonton, Canada, T6G 2HZ. 3MaxEnt Solutions, Cambridge CB3 7HJ, UK Search for other works by this author on: This Site PubMed Google Scholar R. Bordoli R. Bordoli 1Micromass UK Ltd, Wythemhawe, Manchester, M23 9LZ, UK Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (5): A260. https://doi.org/10.1042/bst028a260a Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation D. Gostick, J. Langridge, R. Rachubinski, R. Wozniak, J. Smith, J. Cottrell, J. Hoyes, E. Kapp, J. Skilling, R. Bordoli; Q-Tof ESI-MS/MS and automated software interpretation for de novo sequencing of tryptic peptides from gel separated proteins. Biochem Soc Trans 1 October 2000; 28 (5): A260. doi: https://doi.org/10.1042/bst028a260a Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
Abstract 326: Salt Intake, Drinking Behavior, And The Body Corporate (2014)

Clinical practice and public health advice on salt consumption relies on the generally accepted notion that accurately collected 24-hour urine collections are valid estimates for salt and fluid intake. Reduced salt intake would also reduce thirst and ingestion of sugary drinks accordingly. To test these widely accepted ideas, we performed two independent ultra-long term salt balance studies lasting 105 and 205 days in 10 men simulating a flight to Mars. We fixed dietary intake of all constituents for months at salt intakes of 6, 9, and 12 grams per day and collected all urine. We controlled all environmental factors for rigorous quantitative comparison of urine volume and salt excretion with daily fluid and salt intake. In 1646 collected 24-hour urine samples, our ten subjects recovered 92% of salt they ingested. Due to infradian rhythmical renal salt excretion, only 781 out of 1646 daily urine samples correctly classified a 3 g difference in salt intake (47%). Reducing salt intake from 12 to 6 g reduced 24-hour cortisone excretion (78.3±19.6 vs. 67.2±19.3 μg/d; P&lt;0.001) and increased water intake by 299 ml/d due to reduced glucocorticoid-driven metabolic water production. Even accurately collected 24-hour urine collections at intakes ranging from 6-12 grams salt per day provide no reliable information on individual salt intake. Reducing salt intake leads to reduced glucocorticoid levels decreased metabolic water production and a counterintuitive increase in fluid intake. Traditional views on fluid and electrolyte homeostasis may lead to misinterpretations in clinical practice, public health research, and policy-decision making.
Low-Density InAs Quantum Dots Grown on InP(001) Using Solid-Source Molecular Beam Epitaxy with a Post-Growth Annealing Process (2010)

Low-density InAs quantum dots (QDs) with a large lateral size were grown on InP(001) by solid-source molecular beam epitaxy with a post-growth annealing process. A decrease in QD density with the amount of InAs deposited was shown by atomic force microscopy, and a density of 5×10 8 QDs/cm 2 was obtained for 0.8 monolayer InAs deposition. Moreover, we found that the growth mechanism of QDs changed significantly depending on the amount of InAs deposited in the vicinity of critical thickness, even if the same annealing condition was applied. Near-field photoluminescence spectroscopy of single QDs demonstrated the high optical qualities of low-density QDs.
Isolated orbital mucoceles in the absence of obstructive sinus disease (2017)

Orbital surgeons are quite familiar with the diagnosis and management of paranasal sinus mucoceles due their frequent involvement of the orbit. These benign masses form and expand following sinus outflow obstruction secondary to various causes including trauma, inflammation and malignancy, amongst others. The authors present two cases of isolated orbital mucoceles without associated sinus outflow obstruction. There were notably no connections between the paranasal sinuses and the lesions. The mucoceles were diagnosed following orbitotomies and excisional biopsies with confirmatory histopathology. These rare orbital lesions should be considered when evaluating cystic orbital lesions, and the orbital surgeon should be familiar with the proposed pathophysiology and treatment recommendations.
Maskless extreme ultraviolet lithography (1999)

Masks have been identified as the high risk, high cost issue for extreme ultraviolet (EUV) lithography. Challenges in EUV mask technology such as providing a pellicle and correcting defects have prompted the search for a maskless technique. Here we describe two approaches in which the mask of a current EUV system is replaced by an array of micron-sized mirrors. Patterns are achieved by modulating individual mirrors to create selected bright and dark spots. In one approach, individual mirrors can be lowered by λ/4 to yield locally dark regions because of destructive interference. In another approach, each mirror is mounted on a cantilever. Selected cantilevers can be tilted such that incident light from those mirrors is out of the pupil of the imaging objective. The wafer is mechanically scanned and the object is electronically scrolled across the array of mirrors in order to build up the required pattern. We have simulated the mechanical properties of the micron-sized mirrors and some aerial images showing that sub-100 nm features appear feasible.
A comparison of registration techniques for computer- and image-assisted elbow surgery (2007)

Optimal function following elbow replacement surgery is dependent on the accurate replication of the elbow's flexion-extension axis. Currently, position and orientation of the axis are estimated from visual landmarks. In order to develop computer-assisted techniques to more accurately define this axis, a surface-based registration technique employing a hand-held laser scanner was evaluated against a conventional paired-point registration method to determine whether it produced improved alignment of the flexion-extension axis of the elbow. Registration error was 0.8 +/- 0.3 mm for surface-based registration, compared with 1.9 +/- 1.0 mm for the conventional registration method. These results suggest that the implementation of a surface-based registration technique may lead to a more accurate axis determination and improved clinical outcomes following elbow replacement surgery.
COVID-19 and iron deficiency anemia: relationships of pathogenesis and therapy (2020)

During pregnancy, a woman becomes more susceptible to respiratory and viral diseases, including novel coronavirus infection (COVID-19). Pregnancy exacerbates the acute inflammation typical to COVID-19, elevating a risk of developing cytokine storm, characterized by an avalanche-like spike of inflammation marker concentrations (C-reactive protein, interleukin-1 в, interleukin-6, interferon-Y, ferritin, erythrocyte sedimentation rate etc.). Cytokine storm increases a risk of pregnancy loss and contribute to formation of multiple organ dysfunction syndrome in pregnant women and fetus. In particular, erythrocyte degradation due to acute inflammation leads to hypoxia and uncontrolled inter-tissue iron redistribution. As a result, conditions are created simultaneously for developing pulmonary hemosiderosis and hemosiderosis of other tissues in pregnant woman and fetus, as well as for augmenting iron loss from the body, which exacerbates iron deficiency anemia (IDA). It is important to emphasize that a surge of ferritin level distinctive for severe COVID-19, does not indicate iron overload. Therefore, recommendations to cancel IDA correction and even to use iron chelators in COVID-19 may increase hypoxia and harm the health of pregnant women.
Understanding and suppressing non-radiative losses in methylammonium-free wide-bandgap perovskite solar cells (2021)

We identify the limiting factors of wide bandgap metal halide perovskite solar cells. To overcome these losses, we developed an efficient optimisation strategy and outline the necessary steps for the continued development of these perovskites.
Satellite radio interfaces compatible to 3GPP WCDMA system (2010)

Abstract This paper provides an overview of a technical study on the satellite radio interfaces based on 3GPP WCDMA system. First, the outcome of the technical study is introduced, which has been carried out by the Mobile Satellite System Working Group of the ETSI Satellite Earth Satellite Technical Committee (ETSI TC SES MSS). The study dealt with the configurations and performance of the 3GPP WCDMA (UTRAN) radio interface over a satellite link. Second, as an evolution of satellite‐specific radio interface, the study results are addressed on the possible adaptations of WCDMA to the satellite link in order to maximize the radio link performance. The resultant outcome of the study was reflected in a detail on the G and C families of the satellite radio interface of the ITU‐R Recommendation M.1457, respectively. Copyright © 2010 John Wiley &amp; Sons, Ltd.
Dual-Contrast Dynamic MRI-DOT for Small Animal Imaging (2010)

In this paper we present first-of-its-kind spatially resolved enhancement kinetics of optical and magnetic resonance (MR) agents obtained by a combined MR and Diffuse Optical Tomography (MR-DOT) animal imaging system. A unique MR compatible fiber optic interface allows co-registration of MR and DOT data in space and time. High temporal resolution of the hybrid system permits acquisition of data in dynamic mode. Rats bearing a R3230 AC breast cancer tumor model are used for in vivo studies. Thirty-two optical and thirty MR images are acquired during a single imaging session that lasts nearly ten minutes. Both optical, indocyanine green (ICG), and MR contrast agents, gadolinium-DTPA (Gd-DTPA), are injected simultaneously after the acquisition of several baseline frames. Contrast enhancement time curves obtained by MR and DOT systems both indicate higher average enhancement in tumor regions, up to ten-fold for MRI and 3-fold for DOT, compared to close by non-tumor regions. This feasibility study is the first step towards clinical translation of this hybrid imaging platform. The ultimate aim is to use the enhancement kinetics of the optical agent ICG, which binds to plasma proteins, as complementary information to the kinetics of the MR agent Gd-DTPA, a small molecular agent that does not bind to plasma proteins, to better differentiate benign and malignant lesions.
Group I Paks as therapeutic targets in NF2-deficient meningioma (2015)

Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder characterized by the development of multiple tumors in the central nervous system, most notably schwannomas and meningiomas. Mutational inactivation of NF2 is found in 40-60% of sporadic meningiomas, but the molecular mechanisms underlying malignant changes of meningioma cells remain unclear. Because group I p21-activated kinases (Paks) bind to and are inhibited by the NF2-encoded protein Merlin, we assessed the signaling and anti-tumor effects of three group-I specific Pak inhibitors - Frax597, 716 and 1036 - in NF2-/- meningiomas in vitro and in an orthotopic mouse model. We found that these Pak inhibitors suppressed the proliferation and motility of both benign (Ben-Men1) and malignant (KT21-MG1) meningiomas cells. In addition, we found a strong reduction in phosphorylation of Mek and S6, and decreased cyclin D1 expression in both cell lines after treatment with Pak inhibitors. Using intracranial xenografts of luciferase-expressing KT21-MG1 cells, we found that treated mice showed significant tumor suppression for all three Pak inhibitors. Similar effects were observed in Ben-Men1 cells. Tumors dissected from treated animals exhibited an increase in apoptosis without notable change in proliferation. Collectively, these results suggest that Pak inhibitors might be useful agents in treating NF2-deficient meningiomas.
Photonic band characterization in InGaN/GaN nanocolumn arrays with triangular and honeycomb lattices by angle-resolved micro-photoluminescence measurements (2021)

Abstract We demonstrated photonic band characterization in photonic crystals (PhCs) based on InGaN/GaN nanocolumn (NC) arrays fabricated by Ti-mask selective area growth. Triangular and honeycomb latticed NCs with approximately the same diameter and closest distance were successfully fabricated. To effectively observe the photonic bands, we designed an angle-resolved micro-photoluminescence measurement system. The photonic bands in the honeycomb lattice were at longer wavelengths compared with those in the triangular lattice, indicating that, for the honeycomb lattice, narrower NCs were available to realize PhC effects in the long-wavelength region. Therefore, narrow honeycomb lattices with large nanocrystalline and PhC effects are suitable for long-wavelength emission.
Global Trends of Stroke in Haemodialysis (2000-2012): A Retrospective Cohort Study of the Monitoring Dialysis Outcomes Initiative (2018)

Background Stroke remains a key cause of death&amp;morbidity in HD patients(pts) that exhibit stroke rates 10-12x higher than the general population(GP). Primary&amp;secondary prevention strategies have progressively reduced the burden of stroke in the GP but it is unclear if this trend has transposed to HD pts globally. Methods We studied 4,388 strokes in 150k pts. The MONDO Initiative consists of HD pts from 41 countries [von Gersdorff GD et al.]. All adult pts from the MONDO database [2000-2012] were studied with fatal&amp;non-fatal hospitalized stroke defined by ICD-9&amp;10 codes and excluded transient ischemic attack. Results The overall incidence of stroke rose from 8.7-28.7/1k pt yrs. This compares to static rates worldwide in the GP[2.5-2.6/1k pt yrs,1990-2010] with falling rates in high-income countries. A sharper rise in hemorrhagic stroke rate was seen compared to ischemic stroke in HD pts[Fig], reflecting trends seen in younger age groups worldwide. Despite falling stroke mortality worldwide[1.4-1.1/1k pt yrs,1990-2012], there was a progressive rise in HD populations [1.5-10.5/1k pt yrs, 2000-2012]. These stroke trends occurred despite increasing treatment time[203-245 mins], better BP control[mean pre-HD BP 150/80-137/72mmHg] and falling ultrafiltration rates. Stroke rates remained high 3 months after HD started and continued to fall for 2 yrs, driven by ischemic stroke incidence and with stable hemorrhagic stroke rates. Conclusion There is a progressive rise in stroke incidence and mortality over time in HD pts globally which starkly contrasts with global trends. This appears to be driven predominantly with rising rates of hemorrhagic stroke which carries a higher case-fatality rate. Stroke rates are at their highest within the first year of HD and there is a pressing need to reduce stroke risk in a particularly vulnerable pts at an early stage.
Tofizopam: a benzodiazepine derivative without sedative effect. (1982)

In a single-blind randomized study 47 patients received 100 mg tofizopam orally as a premedication before minor surgery, 50 patients received placebo, an 50 patients no premedication. Both tofizopam and placebo significantly increased the subjective sedative effect of the patients, but there was no significant difference in any of the measured parameters between tofizopam and placebo. In another double-blind randomized study, 49 patients received 100 mg tofizopam three times orally before gynecologic operations and 49 patients received placebo. Compared with placebo, tofizopam had a stimulant action and decreased the excitement of the patients. The effect of tofizopam on apprehension + excitement was significantly better than that of placebo. According to these results, the active component seems to be an unknown metabolite of tofizopam causing a clear drug effect only after repeated oral doses of the parent drug. A slow accumulation in the central nervous system is also possible. In the drug response a wide interindividual variation was found.
Pyrolysis of two-dimensional and three-dimensional interferometrically patterned resist structures (2010)

Interferometric lithography was used to create a wide variety of two-dimensional and three-dimensional patterns in standard photoresist. The patterns were then converted to amorphous carbon structures through pyrolysis in a reducing atmosphere. The structures maintain their fundamental in-plane morphology despite undergoing significant shrinkage. As an indication of their functionality, the authors highlight their use in two diverse applications: (1) as a defect reduction mask in metal-organic chemical vapor deposition growth of gallium nitride (GaN) on sapphire and (2) as a nanoparticle decorated electrode for catalytic oxidation of methanol.
Diverse Mechanistic Pathways and Selectivities in Organo-f-Element-Catalyzed Hydroamination. Intermolecular Organolanthanide-Catalyzed Alkyne and Alkene Hydroamination (1996)

Lanthanide metallocenes catalyze the regiospecific intermolecular addition of primary amines to acetylenic, olefinic, and diene substrates at rates which are ∼1/1000 those of the most rapid intramolecular analogues. Kinetic and mechanistic data argue for turnover-limiting C⋮C/CC insertion into a Ln−N bond, followed by protonolysis of the resulting Ln−C bond.
LC notch filter for image-rejectapplications using on-chip inductors (2001)

An LC notch filter using on-chip spiral inductors for image-reject applications is described. The filter is designed to allow direct automatic frequency and Q-tuning schemes. The excessive noise generation and linearity degradation of bandpass filters are avoided due to the absence of high-Q poles.
Recent advances in Anisotropic Conductive Adhesives (ACAs) technology: Materials and processing (2012)

New ACA materials and processing technologies innovation have been made at various advanced packaging applications such as FOB, FOF, COF, COG, TSP (Touch Screen Panel) and 3D-TSV (Through Silicon Via) assemblies. In ACA materials innovation, noble nanofiber ACA materials with conductive particles incorporated polymer nanofiber finally solve the electrical shortage and unstable contact resistance problems of less than 20 micron ultra-fine pitch COG and COF interconnection, because conductive particle movement can be significantly limited by polymer nanofibers. In addition, new solder ACA materials can significantly solve the current handling capability and reliability limitation of conventional ACAs, because solder ACFs form solder alloy metallurgical joints rather than physical contact based joints of conventional ACFs with metal conductor particles. And new epoxy based photo Active(PA)-ACFs are also introduced to reduce the ACF bonding temperature down to 110 C. In addition, there were progresses made in the area of ACA processing technologies too. New vertical ultrasonic ACA bonding technology provides less than 3 seconds ACA bonding time, reduced assembly thermal damage, good adhesion strength, good contact resistances, and reliability compared with the conventional thermo-compression bonding method. The ultrasonic ACA bonding method has been successfully adapted at the touch screen panel(TSP), FOB and FOF assembly applications. Another ACA processing innovation is the invention of the wafer-level ACA process which significantly reduces the number of processing steps resulting in low cost COB, COF, COG assemblies using ACAs. Furthermore, this wafer-level ACA processing method can be successfully extended to the 3D-TSV vertical interconnection applications too.
VoiSTV (2011)

Until recently, the TV viewing experience has not been a very social activity compared to activities on the World Wide Web. In this work, we will present a Voice-enabled Social TV system (VoiSTV) which allows users to interact, follow and monitor the online social media messages related to a TV show while watching it. Users can create, send, and reply to messages using spoken language. VoiSTV also provides metadata information about TV shows such as trends, hot topics, popularity as well as aggregated sentiment of show-related messages, all of which are valuable for TV program search and recommendation.