gebhart/patrepeval huggingface dataset:
Desmoglein 3-ELISA (1999)

<h3>Background</h3> Pemphigus vulgaris (PV) is an autoimmune-blistering disease of the skin and mucous membranes caused by autoantibodies against desmoglein 3 (Dsg3), an epidermal desmosomal adhesion protein of the cadherin family. Cloning of the<i>Dsg3</i>gene and expression of the protein in a native conformation enabled the recent development of a specific and sensitive enzyme-linked immunosorbent assay (ELISA) for the detection of PV autoantibodies. <h3>Objectives</h3> To evaluate serum samples from patients with PV and other dermatologic diseases for anti-Dsg3 antibodies. To compare ELISA values with autoantibody titers obtained by classic indirect immunofluorescence (IIF). <h3>Design</h3> Serum samples from patients with PV and various other bullous and nonbullous skin diseases were tested for anti-Dsg3 reactivity by ELISA. <h3>Setting</h3> Ambulatory and hospitalized patients from a university hospital. <h3>Patients</h3> Fifty-two serum samples from 11 patients with PV, and serum samples from 11 patients with bullous pemphigoid, 12 patients with other bullous diseases, 22 patients with various nonbullous skin disorders, and 10 healthy individuals were tested. <h3>Results</h3> Forty-seven (98%) of 48 serum samples from patients with PV that were positive by IIF on monkey esophagus were also reactive by Dsg3-ELISA, whereas 4 of 4 IIF-negative PV serum samples showed no reactivity by ELISA. In addition, negative ELISA results were obtained from 11 of 11 serum samples from patients with bullous pemphigoid, 10 of 12 serum samples from patients with other bullous skin disorders, 7 of 9 serum samples from patients with autoimmune-connective tissue diseases, and 13 of 13 serum samples from patients with other nonbullous skin diseases. Interestingly, 1 patient with paraneoplastic pemphigus had positive ELISA results. There was a positive correlation (<i>r</i>= 0.654) between ELISA values and IIF titers within the whole population with PV. In addition, when multiple serum samples from 1 patient with PV sampled over a 2-year period were tested, ELISA reactivity paralleled both the IIF titers and the clinical course. <h3>Conclusion</h3> The Dsg3-ELISA is a sensitive, objective, and PV-specific test that should be considered as an adjunct test for the management of patients with PV.
The influence of finasteride on the volume of the peripheral and periurethral zones of the prostate in men with benign prostatic hyperplasia (1993)

To determine the influence of androgen deprivation induced by the potent 5 alpha-reductase inhibitor finasteride on the volume of the zones of the prostate, 20 symptomatic men with established BPH were randomized to one of three groups: placebo, finasteride 1 mg, and finasteride 5 mg/day. The volume of the entire prostate gland, periurethral zone, and peripheral zone and the seminal vesicles were determined by three dimensional reconstructions of magnetic resonance contoured images of the prostate. There was no significant difference between the results achieved with 1 and 5 mg of finasteride per day; thus the results in these two groups were combined. In the placebo group there was no significant change in the volume of any structure. Following treatment for 1 year with finasteride there was a significant (P < 0.02) 17% decrease in total gland size (11.5 +/- 3.2 cc). Similarly, there was a significant (P < 0.02) 17% decrease in total gland size (11.5 +/- 3.2 cc). Similarly, there was a significant (P < 0.03) decrease in the size of the periurethral zone of the prostate (6.2 +/- 3 cc). Although there was also a decrease in the size of the peripheral zone of the prostate (2.8 +/- 1.2 cc) this did not reach statistical significance. There was no significant change in the volume of the seminal vesicles. These findings indicate for the first time that androgen deprivation induces a significant decrease in the size of the periurethral zone of the prostate in men with established BPH.
Integrated, Distributed Fault Management for Communication Networks (1998)

This report describes an integrated, distributed fault management IDFM system for communication networks.The architecture is based on a distributed intelligent agent paradigm, with probabilistic networks as the framework for knowledge representation and evidence inferencing.A static strategy for generating the suggestive test sequence is proposed, based on which a heuristic dynamic strategy is initiated.Another dynamic strategy, formulated as a Markov decision problem, is also provided.To solve this problem, reinforcement learning techniques are investigated.
Selective Reduction of Dimedone (2009)

The selective hydrogenation of dimedone (1) to the corresponding monoketone 2 over palladium and Amberlyst 15® is reported. The product is a synthetic building block for the fragrance and pharmaceutical industry. Advantages of the new catalytic procedure are the high catalyst activity and selectivity, less by-product formation, avoidance of the presence of acid, and consequently, less salt formation due to the omission of a neutralization step. Using a substrate/catalyst ratio of &gt;100 compound 2 can be synthesized in 97% yield at full conversion. Recycling of the catalyst several times has been shown to be feasible without any detectable decrease in selectivity.
In vitro evaluation of functionalized decellularized muscle scaffold for in situ skeletal muscle regeneration (2019)

Current treatment options for repairing volumetric muscle loss injury involve the use of existing host tissue like muscular flaps or grafts. However, host muscle tissue may not be available and donor site morbidity, such as functional loss and volume deficiency, is often present. In this study, we developed a biofunctionalized muscle-derived decellularized extracellular matrix scaffolding system to utilize endogenous stem/progenitor cells for in situ muscle tissue regeneration. We optimized the decellularization process to enhance cellular infiltration and fabricated an insulin-like growth factor-binding protein 3 (IGFBP-3)-conjugated scaffold for controlled delivery of IGF-I. We then tested in vitro characterization including IGF-I release kinetics and cellular infiltration. In addition, we have analyzed the bioactivities of skeletal muscle cells (C2C12) to assess the indirect effect of released IGF-1 from the scaffold. The IGFBP-3 conjugated scaffolds demonstrated showed sustained release of IGF-1 and 1% SDS decellularized scaffold with IGF-1 showed higher cellular infiltration compared to control scaffolds (no conjugation). In indirect bioactivity assay, IGF-1 conjugated scaffold showed 2.1-fold increased cell activity compared to control (fresh media). Our results indicate that IGFBP-3/IGF-I conjugated scaffold has the potential to be used for in situ muscle tissue regeneration.
Conformation of gramicidin A (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformation of gramicidin AWilliam R. Veatch, Eric T. Fossel, and Elkan R. BloutCite this: Biochemistry 1974, 13, 26, 5249–5256Publication Date (Print):December 1, 1974Publication History Published online1 May 2002Published inissue 1 December 1974https://pubs.acs.org/doi/10.1021/bi00723a001https://doi.org/10.1021/bi00723a001research-articleACS PublicationsRequest reuse permissionsArticle Views511Altmetric-Citations310LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Linear and Dirty‐Paper Techniques for the Multiuser MIMO Downlink (2005)

This chapter contains sections titled: Introduction Background and Notation Single Antenna Receivers Multiple Antenna Receivers Open Problems Summary References
Optical Transmitter Equalization With Tunable Mismatched Terminations in a Silicon Modulator (2022)

We demonstrate a 2.5 mm silicon photonics traveling-wave Mach-Zehnder modulator with on-chip tunable termination to study termination mismatching as a technique for optimizing modulator performance by leveraging the monolithic integration of electronic and photonic devices. Time domain reflectometry measurements demonstrate the tunability of the termination impedance with respect to the modulator transmission line Z <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> . Electro-optic frequency response measurements show the bandwidth enhancement effect of the termination mismatch, whereby a 3 dB bandwidth above 40 GHz was achieved. Optical link time-domain measurements were performed to optimize the termination mismatch for maximum eye-diagram opening at 50 Gb/s. Our measurements demonstrate that active on-chip termination can be utilized to optimize the modulator performance and mitigate the risk incurred from fabrication variations which can result in a sub-optimal termination impedance.
Mutation Analysis of theMEN1Gene in Multiple Endocrine Neoplasia Type 1, Familial Acromegaly and Familial Isolated Hyperparathyroidism1 (1998)

Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant disease characterized by neoplasia of the parathyroid glands, the endocrine pancreas, and the anterior pituitary gland. In addition, families with isolated endocrine neoplasia, notably familial isolated hyperparathyroidism (FIHP) and familial acromegaly, have also been reported. However, whether these families constitute MEN 1 variants or separate entities remains speculative as the genetic bases for these diseases are unclear. The gene for MEN 1 has recently been cloned and characterized. Using single strand conformation analysis (SSCA) and sequencing, we performed mutation analysis in: a) a total of 55 MEN 1 families from 7 countries, b) 13 isolated MEN 1 cases without family history of the disease, c) 8 acromegaly families, and d) 4 FIHP families. Mutations were identified in 27 MEN 1 families and 9 isolated cases. The 22 different mutations spread across most of the 9 translated exons and included frameshift (11), nonsense (6), splice (2), missense mutations (2), and in-frame deletions (1). Among the 19 Finnish MEN 1 probands, a 1466del12 mutation was identified in 6 families with identical 11q13 haplotypes and in 2 isolated cases indicating a common founder. One frameshift mutation caused by 359del4 (GTCT) was found in 1 isolated case and 4 kindreds of different origin and haplotypes; this mutation therefore represents a common "warm" spot in the MEN1 gene. By analyzing the DNA of the parents of an isolated case one mutation was confirmed to be de novo. No mutation was found in any of the acromegaly and small FIHP families, suggesting that genetic defects other than the MEN1 gene might be involved and that additional such families need to be analyzed.
ChemInform Abstract: Strobilurin M, Tetrachloropyrocatechol and Tetrachloropyrocatechol Methyl Ether: New Antibiotics from a Mycena Species. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Comparison of Needlescopic Appendectomy Versus Conventional Laparoscopic Appendectomy. A Randomized Controlled Trial (2005)

No AccessJournal of UrologyUrological Survey: Urolithiasis/Endourology: Urolithiasis, Endourology and Laparoscopy1 Nov 2005Comparison of Needlescopic Appendectomy Versus Conventional Laparoscopic Appendectomy. A Randomized Controlled Trial Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)68809-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Comparison of Needlescopic Appendectomy Versus Conventional Laparoscopic Appendectomy. A Randomized Controlled Trial." The Journal of Urology, 174(5), pp. 1848–1849 © 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 174Issue 5November 2005Page: 1848-1849 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement PDF DownloadLoading ...
Enhancing retention and recovery of particles in a standing wave chamber by modulating frequency and amplitude (2020)

Magnetic, electric, gravitational and acoustic field forces can be used to concentrate and separate particles. Here we focus on separating cells from a feed suspension using multidimensional acoustic standing waves to trap, cluster and gravitationally settle the cells. The application is concentration of cell cultures for cell therapy manufacturing. Process efficiency depends on frequency, power and settling time. Efficiency is enhanced by frequency and amplitude modulation. The acoustic standing wave is operated at its resonance frequency. Particle concentration and temperature affect the resonator frequency and may detune the system, resulting in lower retention. Exciting the field with multiple closely spaced frequencies increased particle retention between 5%–20% by changing the modulation and central frequency of the excitation signal. At the end of the retention process, the acoustic chamber is full of clusters which are sedimented into the collector. As cell clusters settle, they start dispersing in the fluid medium which impacts recovery. Use of an amplitude modulated acoustic wave during sedimentation reduces particle loss in the supernatant. As amplitude decreases, clusters start to settle. Before cells start to disperse, amplitude is increased to re-cluster the cells. This cycle repeats multiple times and increases cell recovery by 10%–30%.
Classification of marine organisms in underwater images using CQ-HMAX biologically inspired color approach (2013)

In many coastal environments, particularly in tropical zones, coral reef ecosystems have exceptional biodiversity, contribute to coastal defense, provide unique and important habitats and valuable commercial resources. Assessment of environmental impacts on biodiversity in such areas are increasingly important to mitigate potential adverse effects on specific ecosystems. Visual classification of marine organisms is necessary for population estimates of individual species of corals or other benthic organisms. In this paper, we introduce a new image dataset of benthic organisms that are of different colors, shapes, scales, visibility and are taken from different viewpoints. We evaluate several different classification approaches on this dataset, and show that CQ-HMAX, our new biologically inspired approach to utilizing color information for object and scene recognition, that is inspired by the characteristics of color- and object-selective neurons in the high-level inferotemporal (IT) cortex of the primate visual system, results in better classification results in comparison with existing computational models such as support vectors machines, SIFT based approaches and the HMAX biologically inspired approach. We show that concatenating our model which encodes color information with the HMAX model which encodes grayscale shape information results in the highest classification accuracy.
A cognitive simulation model for novice text entry on cell phone keypads (2007)

Motivation -- To create a cognitive simulation model that predicts text entry performance and learning on cell phone keypads by novice users.
Synthesis and in Vivo Evaluation of Phenethylpiperazine Amides: Selective 5-Hydroxytryptamine2AReceptor Antagonists for the Treatment of Insomnia (2010)

Recent developments in sleep research suggest that antagonism of the serotonin 5-HT(2A) receptor may improve sleep maintenance insomnia. We herein report the discovery of a series of potent and selective serotonin 5-HT(2A) receptor antagonists based on a phenethylpiperazine amide core structure. When tested in a rat sleep pharmacology model, these compounds increased both sleep consolidation and deep sleep. Within this series of compounds, an improvement in the metabolic stability of early leads was achieved by introducing a carbonyl group into the phenethylpiperazine linker. Of note, compounds 14 and 27 exhibited potent 5-HT(2A) receptor binding affinity, high selectivity over the 5-HT(2C) receptor, favorable CNS partitioning, and good pharmacokinetic and early safety profiles. In vivo, these two compounds showed dose-dependent, statistically significant improvements on deep sleep (delta power) and sleep consolidation at doses as low as 0.1 mg/kg.
OFDM Remodulation for 10-Gb/s/channel WDM-PON with Simple Carrier Extraction and Enhanced Tolerance to Rayleigh Noise (2012)

A novel OFDM-remodulation scheme for 10-Gb/s/channel WDM-PON is proposed and numerically investigated. Negative remodulation penalty is achieved without using any ultra-narrow filter or coherent detection. 40-km single-fiber bidirectional transmission is confirmed with 7-dB power margin.
Abstract 985: The mutational landscape of LN metastasis and recurrence in HNSCC (2014)

Abstract Recent whole exome sequencing (WES) studies have reported the mutations that characterize primary head and neck squamous cell carcinomas (HNSCC). While exposure to tobacco, alcohol and HPV infection are known to contribute to HNSCC development and prognosis, the largest obstacle to long term survival is recurrent and metastatic disease. Approximately 50% of patients present with synchronous lymph node metastases (SLNM), where 5-year adjusted survival is ≈85% for patients without SLNM compared with 30-60% in patients with SLNM. 20-30% of patients cured of their primary HNSCC go on to develop recurrent disease, which is usually refractory to standard therapies. Here, we report the first WES study of paired primary tumor and SLNM from 14 HNSCC patients, and paired primary tumor and metachronous loco-regional metastases (MLRM) from 11 HNSCC patients. Primary tumors averaged 67 nonsynonymous mutations per tumor (n=21), SLNM averaged 89.3 (n=12), and MLRM averaged 41.7 (n=9). TP53 was the only gene mutated in a majority (57%) of primary tumors in our cohort. We observed similar rates of mutation in several of the TCGA-defined “HNSCC signature” genes in our primary cohort, including FAT1 (14.3%) and CASP8 (4.8%), among others. While the size of our cohort does not allow for appropriately powered statistical analyses; 206 and 204 genes, were mutated in metastatic tumors, but not the respective paired primary tumors, in the SLNM and MLRM cohorts, respectively. AP2B1 and ITPR3 mutations were enriched in SLNM, as newly acquired mutations were seen in multiple (2 and 2/12) SLNM samples. GLUL and DDR2 mutations were enriched in MLRM, as newly acquired mutations were seen in multiple (2 and 2/9) MLRM samples. All 4 genes have previously been implicated in the metastatic process in other cancers. The potential enrichment of DDR2 mutations in HNSCC metastases is especially intriguing, as mutations in this gene have been shown to confer sensitivity to the SRC-family kinase inhibitor, dasatinib, in lung and breast cancer. Here we report exquisite sensitivity to dasatinib in our HNSCC preclinical models harboring DDR2 mutations, suggesting further investigation of this drug is warranted in recurrent HNSCC. Citation Format: Matthew Louis Hedberg, Gerald Goh, Maria Freilino, Yan Zeng, Vivian WY Lui, Roy S. Herbst, Richard P. Lifton, Jennifer R. Grandis. The mutational landscape of LN metastasis and recurrence in HNSCC. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 985. doi:10.1158/1538-7445.AM2014-985
ChemInform Abstract: Ring Lithiation and Functionalization of Imidazol‐2‐ylidene‐boranes. (2012)

Abstract A double functionalization at both C‐4 and C‐5 of substrates (I) is possible in either one or two steps to produce derivatives which are of interest as catalysts or complexation agents.
Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles (2003)

Microtubule plus ends dynamically attach to kinetochores on mitotic chromosomes. We directly imaged this dynamic interface using high resolution fluorescent speckle microscopy and direct labeling of kinetochores in Xenopus extract spindles. During metaphase, kinetochores were stationary and under tension while plus end polymerization and poleward microtubule flux (flux) occurred at velocities varying from 1.5-2.5 micro m/min. Because kinetochore microtubules polymerize at metaphase kinetochores, the primary source of kinetochore tension must be the spindle forces that produce flux and not a kinetochore-based mechanism. We infer that the kinetochore resists translocation of kinetochore microtubules through their attachment sites, and that the polymerization state of the kinetochore acts a "slip-clutch" mechanism that prevents detachment at high tension. At anaphase onset, kinetochores switched to depolymerization of microtubule plus ends, resulting in chromosome-to-pole rates transiently greater than flux. Kinetochores switched from persistent depolymerization to persistent polymerization and back again during anaphase, bistability exhibited by kinetochores in vertebrate tissue cells. These results provide the most complete description of spindle microtubule poleward flux to date, with important implications for the microtubule-kinetochore interface and for how flux regulates kinetochore function.
Non-destructive reversible resistive switching in Cr doped Mott insulator Ca2RuO4: Interface vs bulk effects (2017)

A non-destructive reversible resistive switching is demonstrated in single crystals of Cr-doped Mott insulator Ca2RuO4. An applied electrical bias was shown to reduce the DC resistance of the crystal by as much as 75%. The original resistance of the sample could be restored by applying an electrical bias of opposite polarity. We have studied this resistive switching as a function of the bias strength, applied magnetic field, and temperature. A combination of 2-, 3-, and 4-probe measurements provide a means to distinguish between bulk and interfacial contributions to the switching and suggests that the switching is mostly an interfacial effect. The switching was tentatively attributed to electric-field driven lattice distortions which accompany the impurity-induced Mott transition. This field effect was confirmed by temperature-dependent resistivity measurements which show that the activation energy of this material can be tuned by an applied DC electrical bias. The observed resistance switching can potentially be used for building non-volatile memory devices like resistive random access memory.
5-(Z)-oct-2-enyltetrahydrofuran-2-one as a key intermediate in the synthesis of leukotriene B4 (1989)

G. Dormán, S. M. Roberts, B. J. Wakefield and J. A. Winders, J. Chem. Soc., Perkin Trans. 1, 1989, 1543 DOI: 10.1039/P19890001543