gebhart/patrepeval huggingface dataset:
Permanent, post-fabrication trimming of polarization diversity silicon circuits by single fs laser pulses (2014)

Single 400 nm femtosecond laser pulses were used to perform phase trimming of a polarization diversity, DPSK demodulator based on silicon photonics. The technique may be applied to tune any phase sensitive silicon circuit.
Doublet Pulse Coherent Laser Radar for Tracking of Resident Space Objects (2014)

In this paper, the development of a long range ladar system known as ExoSPEAR at NASA Langley Research Center for tracking rapidly moving resident space objects is discussed. Based on 100 W, nanosecond class, near-IR laser, this ladar system with coherent detection technique is currently being investigated for short dwell time measurements of resident space objects (RSOs) in LEO and beyond for space surveillance applications. This unique ladar architecture is configured using a continuously agile doublet-pulse waveform scheme coupled to a closed-loop tracking and control loop approach to simultaneously achieve mm class range precision and mm/s velocity precision and hence obtain unprecedented track accuracies. Salient features of the design architecture followed by performance modeling and engagement simulations illustrating the dependence of range and velocity precision in LEO orbits on ladar parameters are presented. Estimated limits on detectable optical cross sections of RSOs in LEO orbits are discussed.
ChemInform Abstract: The Stereoselective Cyclopropanation of Chiral Allylic Alcohols Using a Chiral Dioxaborolane Ligand: A New Route to anti‐Cyclopropylmethanol Derivatives. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Papillary renal cell carcinoma revisited: a comprehensive histomorphologic study with outcome correlations (2014)

Papillary renal cell carcinoma (P-RCC) is the second most common type of malignant renal epithelial tumor and can be subclassified into type 1, which demonstrates simple cuboidal low-grade epithelium and type 2, which demonstrates pseudostratified high-grade epithelium with abundant eosinophilic cytoplasm. Despite this clinically useful subclassification, P-RCCs exhibit considerable histomorphologic diversity, with many cases having features differing from classically described type 1 and type 2 tumors. To our knowledge, there has been no recent study that has methodically evaluated the histomorphologic features of a series of P-RCCs. To address this, we evaluated a cohort of P-RCCs diagnosed between 1997 and 2004 with long-term clinical follow-up data (n = 56). Histomorphologic features previously described in the spectrum of type 1 and type 2 P-RCCs were recorded for each tumor, including nuclear grade, complete tumor capsule, and cytoplasmic eosinophilia as well as several other features. The current TNM staging (American Joint Committee on Cancer, seventh edition) was assigned to all cases. Histomorphologic features were diverse, demonstrating classic type 1 P-RCC and classic type 2 P-RCC morphology and several tumors with nonclassic features. Four patients in this cohort had distant metastasis. The primary tumor was equally divided between type 1 (2 cases) and type 2 (2 cases) morphology in the cases with metastasis. All P-RCC cases with metastases demonstrated presence of high nuclear grade and high tumor stage in the primary tumor. Cluster analysis using staging parameters and histomorphologic features divided tumors into 2 primary clusters. All primary tumors associated with metastasis were in the same cluster.
Advanced channel access techniques (2013)

This chapter introduces some of the advanced channel access techniques in the 802.11 standard. In addition to, and built upon, the distributed channel access techniques described in Chapter 7, the 802.11 standard includes two centrally coordinated channel access techniques. The PCF was introduced in the original 802.11 specification and HCCA was introduced in the 802.11e amendment to support parameterized QoS and to fix some of the deficiencies in the PCF. The chapter then introduces new channel access techniques in the 802.11n amendment.
Nasal‐Associated Lymphoid Tissue and Olfactory Epithelium as Portals of Entry forBurkholderia pseudomalleiin Murine Melioidosis (2009)

These data suggest that the olfactory nerve is the route of entry into the brain and that this route of entry may be paralleled in cases of human neurologic melioidosis. This study focuses attention on the upper respiratory tract as a portal of entry, specifically focusing on NALT as a route for the development of systemic infection via the bloodstream and on the olfactory epithelium as a direct route to the brain.
A Practical Synthesis of α-AminoKetones via Aryllithium Addition to N-Boc-α-AminoAcids (2003)

The reaction of N-Boc-α-amino acids with aryllithium reagents followed by removal of the nitrogen protecting group provides enantiomerically pure α-amino aryl ketones as their corresponding HCl salts. This practical two-step sequence gives rapid access to a pharmaceutically interesting class of compounds from commercially available starting materials.
Supplementary Figure 1 from Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression (2023)

&lt;p&gt;PDF file - 737KB, Supplemental Figure 1: Apoptosis antibody array result of Uacc903-V1 and -G2.&lt;/p&gt;
Toxicological Evaluation of a Probiotic-Based Delivery System for P8 Protein as an Anti-Colorectal Cancer Drug (2021)

These non-clinical toxicology studies could be used to furnish valuable data for the safety certification of PP-P8.
Fundamentals of Manufacturing and Electrostatics (2012)

In this chapter, the subject of electrostatic discharge (ESD) control, measurement and verification is addressed for manufacturing environments. It talks about test equipment, protective equipment, and materials. This discussion is followed by ESD control programs and audits. ESD concerns in manufacturing are a combination of the materials, tooling, and the human factors. The materials influence the triboelectric charge transfer. The choice of ESD materials in a manufacturing environment can have a large effect on the ESD protected area (EPA). The material choice can influence its initial conductivity, as well as the conductivity as a function of time. The chapter discusses the categories that are present in the manufacturing environment. Some of these include: worksurfaces, wrist straps, seating and packaging. To have a successful ESD program it is important to establish an auditing process to evaluate conformance on establishing the manufacturing environment, and continuous evaluation. Controlled Vocabulary Terms electrostatic discharge; electrostatics
The effect of progesterone and its metabolites on the interictal epileptiform discharge in the cat's cerebral cortex (1987)

The antiepileptic effect of progesterone, 5-alpha-pregnane-3,20-dione, 3-alpha-hydroxy-5-alpha-pregnane-20-one, and 3-alpha-hydroxy-5-beta-pregnane-20-one were tested in an experimental animal model, and compared with the effect of clonazepam. The steroids were dissolved in serum from ovariectomized cats. Ovariectomized adult cats were used and spontaneous epileptic discharges were generated by placing small pieces of penicillin-soaked filter papers on the ipsi and contralateral cerebral cortex. The frequency and amplitude of the interictal epileptiform spikes were recorded, and analysed in a computer. The changes in frequency and amplitudes were calculated. The drugs were infused during 20-s periods into one cerebral hemisphere via the ipsilateral lingual artery with speeds of 1.1, 3.4 and 6.3 ml min-1. A penicillin focus on the contralateral hemisphere served as a simultaneous control. Progesterone and clonazepam showed similar inhibitory effects on epileptiform interictal spiking (median reduction of spike frequency 21%, cf. Table I). The 5-alpha-pregnane-3, 20-dione was generally less potent than progesterone (median reduction 9%) and the 5-alpha- and 5-beta-pregnanolones were two to three times more potent than progesterone (54-66% reduction). The latency of the inhibitory effect was 4-10 s measured from the entrance of the infusion into the lingual artery. The depression lasted 10-20 min. It is concluded that the pregnanolones have strong antiepileptic properties. The rapid onset of effect indicates that the steroids may interact with the neuronal function at the membrane or synaptic levels.
Biosynthesis of vitamin B12: when is the 12β-methyl group of the vitamin generated by acetate decarboxylation? (1988)

The 12-methyl analogue (13) of the aromatised form of precorrin-3(5) has been prepared by enzymic C-methylation of 12-decarboxy-uro'gen-III (2) and is used for incorporation experiments which indicate that decarboxylation of the 12-acetate residue in B12-biosynthesis occurs after C-17 methylation.
Histone deacetylase inhibitors induce mitochondrial elongation (2011)

Although various stimuli-inducing cell demise are known to alter mitochondrial morphology, it is currently debated whether alteration of mitochondrial morphology is per se responsible for apoptosis execution or prevention. This study was undertaken to examine the effect of histone deacetylase (HDAC) inhibitors on mitochondrial fusion-fission equilibrium. The mechanism underlying HDAC inhibitor-induced alteration of mitochondrial morphology was examined in various cells including primary cultured cells and untransformed and cancer cell lines treated with seven different HDAC inhibitors. Suberoylanilide hydroxamic acid (SAHA)-induced mitochondrial elongation in both Hep3B and Bcl-2-overexpressing Hep3B cells, apart from its apoptosis induction function. SAHA significantly decreased the expression of mitochondrial fission protein Fis1 and reduced the translocation of Drp1 to the mitochondria. Fis1 overexpression attenuated SAHA-induced mitochondrial elongation. In addition, depletion of mitochondrial fusion proteins, Mfn1 or Opa1, by RNA interference also attenuated SAHA-induced mitochondrial elongation. All of the HDAC inhibitors we examined induced mitochondrial elongation in all the cell types tested at both subtoxic and toxic concentrations. These results indicate that HDAC inhibitors induce mitochondrial elongation, irrespective of the induction of apoptosis, which may be linked to alterations of mitochondrial dynamics regulated by mitochondrial morphology-regulating proteins. Since mitochondria have recently emerged as attractive targets for cancer therapy, our findings that HDAC inhibitors altered mitochondrial morphology may support the rationale for these agents as novel therapeutic approaches against cancer. Further, the present study may provide insight into a valuable experimental strategy for simple manipulation of mitochondrial morphology.
Performance of Interference Rejection Combining Receiver to Suppress Inter-Cell Interference in LTE-Advanced Downlink (2011)

The interference rejection combining (IRC) receiver, which can suppress inter-cell interference, is effective in improving the cell-edge user throughput. The IRC receiver is typically based on the minimum mean square error (MMSE) criteria, which requires highly accurate channel estimation and covariance matrix estimation that includes the inter-cell interference. This paper investigates the gain from the IRC receiver in terms of the downlink user throughput performance in a multi-cell environment. In the evaluation, to assess the actual gain, the inter-cell interference signals including reference signals from the surrounding 56 cells are generated in the same way as the desired signals, and the channel propagation from all of the cells is explicitly taken into account considering pathloss, shadowing, and multipath fading. The results of simulations that assume the inter-site distance of 500m, the spatial correlation at the transmitter and the receiver of 0.5, and the numbers of transmitter and receiver antennas of 2 and 2, respectively, show that the IRC receiver improves the cell-edge user throughput (defined as the 5% value in the cumulative distribution function) by approximately 15% compared to the simplified MMSE receiver that approximates the inter-cell interference as AWGN, at the cost of a drop in the average user throughput due to less accurate channel and covariance matrices. Furthermore, we consider dynamic switching between the IRC receiver and the simplified MMSE receiver according to the number of streams and modulation and coding scheme levels. The results show that with dynamic switching, both the cell-edge throughput and average user throughput are improved to the same level as that for the IRC receiver and the simplified MMSE receiver, respectively. Therefore, the best performance can be achieved by employing the dynamic switching in all throughput regions.
Visual Acuity is Essential for Optimal Visual Performance of NFL Players (2010)

The measurement of static visual acuity (SVA) is an essential element of any vision evaluation because degraded visual acuity can have a detrimental effect on many other aspects of visual performance. Although the expected level of SVA depends on the visual task demands of each sport situation, studies have frequently found better SVA in athletes than in nonathletes. The purpose of this study was to compare performance of visual and visuomotor skills in a population of NFL football players with excellent and reduced SVA. Eighty-two NFL football players received a visual performance evaluation at their team's training center over a span of 2 seasons. Based on the athletes' SVA and refractive error measures, they were identified for a referral to an eye care practitioner for potential remediation. An athlete was identified for a referral if (1) SVA of either or both eyes was worse than 20/17 on a Snellen chart or (2) there was significant hyperopia in either eye (cyl ≥ 1.5 diopter). Twenty-eight of the 82 players were identified for a referral. Statistically, the referred and the non-referred population had significantly different SVA (p<0.001). Of the visual performance variables measured, the non-referred players were better than the referred players in the following visual and visuomotor skills: contrast sensitivity (p=0.008), accommodative facility (p<0.001), depth perception (p=0.017), reaction time (p<0.001), and target acquisition (p=0.030). Some of the other skills measured that did not result in statistical significance were perception span, motor response time, anticipation timing, eye-hand coordination, and target following. There is a statistically significant reduction in some measures of visual performance in NFL football players who have SVA worse than 20/17. Excellent SVA contributes to optimal visual performance when central vision factors into success. Professional football players may benefit from refractive compensation to maximize SVA.
Evaluation of Advanced Two-Phase Flow and Combustion Models for Predicting Low Emission Combustors (2000)

The development of low-emission aero-engine combustors strongly depends on the availability of accurate and efficient numerical models. The prediction of the interaction between two-phase flow and chemical combustion is one of the major objectives of the simulation of combustor flows. In this paper, predictions of a swirl stabilized model combustor are compared to experimental data. The computational method is based on an Eulerian two-phase model in conjunction with an eddy dissipation (ED) and a presumed-shape-PDF (JPDF) combustion model. The combination of an Eulerian two-phase model with a JPDF combustion model is a novelty. It was found to give good agreement to the experimental data.
Interaction of the antitumour antibiotic streptonigrin with DNA and oligonucleotides. (1997)

The interaction of the aminoquinone antitumour antibiotic streptonigrin with plasmid DNA, calf thymus DNA and oligonucleotides, in the presence and absence of metal ions, has been studied using circular dichroism, NMR spectroscopy and gel electrophoresis experiments. In the absence of metal ions, streptonigrin does not interact with DNA. Incubation of the two enantiomers of streptonigrin with calf thymus DNA, in the presence of excess zinc(II), showed no evidence of selective interaction of the natural enantiomer, (R)-streptonigrin, with the DNA by circular dichroism. The interaction of streptonigrin with the hexanucleotide d(GCATGC)2 was studied by 1H- and 31P-NMR spectroscopy. In the presence of four equivalents of zinc(II) nitrate and one equivalent of streptonigrin, small changes in chemical shifts of the proton resonances associated with T4 and G5 were detected as well as P4 and P5, consistent with a weak interaction of the zinc(II)-streptonigrin complex with the most accessible binding sites, involving the phosphate groups and guanine N7, at either end of the duplex. In contrast, no significant interaction between the metal complex and d(ATGCAT)2 was detected. Gel electrophoresis experiments were carried out to probe the sequence specificity of the interaction of the non-covalent streptonigrin-metal complexes with DNA, the DNA cleavage reaction of supercoiled DNA, and the specificity of the cleavage reaction. DNase I footprinting showed no sequence specific interactions. Zinc(II), copper(II) and manganese(II) enhanced the cleavage of supercoiled DNA into nicked and linear forms of DNA, while magnesium showed no cleavage reactions under identical conditions. The DNA cleavage reaction of streptonigrin and NADH in the presence and absence of metal ions was studied. Overall, little sequence specificity was observed, but slightly different cleavage patterns suggest that the DNA cleavage can be influenced by the nature of the metal ions.
Angular analysis and differential branching fraction of the decay B s 0  → ϕμ + μ − (2015)

An angular analysis and a measurement of the differential branching fraction of the decay B 0 s + -are presented, using data corresponding to an integrated luminosity of 3.0 fb -1 of pp collisions recorded by the LHCb experiment at s = 7 and 8 TeV. Measurements are reported as a function of q 2 , the square of the dimuon invariant mass and results of the angular analysis are found to be consistent with the Standard Model. In the range 1 < q 2 < 6 GeV 2 /c 4 , where precise theoretical calculations are available, the differential branching fraction is found to be more than 3 below the Standard Model predictions.
Effect of Scale Microstructure on Scale Adhesion of Low Carbon Sheet Steel (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
A microfluidic platform with castellated electrodes to separate cancer cells from blood cells (2020)

This paper introduces a dielectrophoresis-based platform for the separation of cancer cells from blood cells. The platform consists of a two-layered device: a glass wafer with embedded castellated electrodes and a polydimethylsiloxane (PDMS) channel bonded on top of the glass wafer. The castellated electrodes generate a non-uniform electric field and exert dielectrophoretic force on cells suspended in a low-conductivity medium. The magnitude and direction of the force acting on different cells depend on the applied frequency along with difference in the dielectric properties of each type of cells and the suspension medium. In the experiment, a mixed sample of blood cells and MDA-MB-231 breast cancer cells, both suspended in a low conductive isotonic solution, were injected into the microchannel using a syringe pump. The applied frequency is tuned in such a way that the MDA-MB-231 cancer cells were attracted towards electrode tips whereas the blood cells were repelled away from the electrode tips to achieve successful separation.
Phenothiazine dioxide based high triplet energy host materials for blue phosphorescent organic light-emitting diodes (2015)

Donor–acceptor type high triplet energy host materials were derived from a phenothiazine dioxide based electron transport moiety and a carbazole based hole transport moiety.
Phosphatidylcholine Passes by Paracellular Transport to the Apical Side of the Polarized Biliary Tumor Cell Line Mz-ChA-1 (2019)

Phosphatidylcholine (PC) translocation into mucus of the intestine was shown to occur via a paracellular transport across the apical/lateral tight junction (TJ) barrier. In case this could also be operative in biliary epithelial cells, this may have implication for the pathogenesis of primary sclerosing cholangitis (PSC). We here evaluated the transport of PC across polarized cholangiocytes. Therefore, the biliary tumor cell line Mz-ChA-1 was grown to confluency. In transwell culture systems the translocation of PC to the apical compartment was analyzed. After 21 days in culture, polarized Mz-ChA-1 cells revealed a predominant apical translocation of choline containing phospholipids including PC with minimal intracellular accumulation. Transport was suppressed by TJ destruction employing chemical inhibitors and pretreatment with siRNA to TJ forming proteins as well as the apical transmembrane mucin 3 as PC acceptor. Apical translocation was dependent on a negative apical electrical potential created by the cystic fibrosis transmembrane conductance regulator (CFTR) and the anion exchange protein 2 (AE2). It was stimulated by apical application of secretory mucins. The results indicated the existence of a paracellular PC passage across apical/lateral TJ of the polarized biliary epithelial tumor cell line Mz-ChA-1. This has implication for the generation of a protective mucus barrier in the biliary tree.
Synthesis of ZnxCd1−xS thin film by dip-coating method and its photocatalytic activity (2006)

ZnS shows high photocatalytic activity, nevertheless the operating wavelength is limited to less than 330 nm. On the other hand, CdS can be used at wavelength up to 512 nm. However, CdS requires Pt as supporting catalyst. We have synthesized Pt‐free ZnxCd1−xS particles with x varying between 0 and 1 by co‐precipitation method and evaluated their photocatalytic activities. The highest photocatalytic activity was recorded for Zn0.67Cd0.33S particles. Then, ZnxCd1−xS solid solution films were prepared using the above particles by dip‐coating method and their photocatalytic activities were evaluated.
A reverse-coupled bipolar coil structure for an integrated LCC-compensated inductive power transfer system (2018)

This paper proposes a reverse-coupled bipolar coil structure to realize an integrated LCC-compensated inductive power transfer (IPT) system. Two unipolar coils are connected reversely, resulting in a bipolar structure, which is used as the compensation inductor in an LCC-compensated IPT system. This bipolar coil is integrated into the main coil to save space, and its dimensions are designed to eliminate its magnetic coupling with the same-side main coil and simplify the circuit analysis. The working principle of the integrated IPT system is presented, which shows that the proposed bipolar coil can help improve the system performance with position and angular misalignment in the horizontal plane. A prototype is designed and implemented to validate the proposed bipolar coil structure. The primary coil dimension is 450mm×450mm, and the secondary coil size is 300mm ×300mm. Experiments show that it can achieve 2.15kW power transfer with 89.9% dc-dc efficiency across an airgap of 200mm. When there is 150mm misalignment, the system power and efficiency are not significantly affected, and it can still maintain 80.5% of the well-aligned power with 89.0% efficiency.