gebhart/patrepeval huggingface dataset:
Scribable multi-walled carbon nanotube-silicon nanocomposites: a viable lithium-ion battery system (2015)

A novel electrode fabrication technique involving a manual scribing action of vertically aligned silicon coated multiwall carbon nanotubes (VASCNTs) on a copper foil have been developed as a viable approach to Li-ion battery electrodes. The scribed electrodes were prepared without the use of any conductive additives and binders, and they were directly assembled in a coin cell. These 'binder-less' scribed Si-CNT electrodes exhibited a very high discharge capacity in excess of 3000 mA h g(-1) and a low first cycle irreversible loss (FIR) (19%). In addition, the electrodes also showed good cyclability with capacity retention of 76% at the end of 50 cycles corresponding to a fade rate of 0.48% loss per cycle rendering the technique attractive for suitable Li-ion applications.
ChemInform Abstract: A One‐Pot Synthesis of Ring‐Fused 1,3,5‐Triazine‐2,4(3H)‐diones: Reactions with Chlorocarbonyl Isocyanate. (1986)

Abstract Die α‐Amino‐N‐Heteroaromaten (I) und (IV) werden mit Chlorcarbonylisocyanat (II) zu den Triazin‐dionen (III) und (V) cyclokondensiert.
Mechanism of intercalation: Ion effects on the equilibrium and kinetic constants for the interaction of propidium and ethidium with DNA (1985)

Abstract The effects of sodium ion concentration on the binding isotherms and association and dissociation reaction rates for the interaction of the closely related intercalating dication, propidium, and the monocation, ethidium, with DNA have been determined by spectrophotometric binding and stopped‐flow kinetics methods. The binding of propidium to DNA is best described by a neighbor‐exclusion binding isotherm (two base pairs per binding site) with negative ligand cooperatively on binding. The cooperativity parameter is fairly independent of salt concentration, while the log of the observed equilibrium binding constant varies with −log [Na + ], with a slope of two for the propidium–DNA interaction. These effects of the sodium ion on the equilibrium binding of propidium with DNA are similar to those previously described for the dication, quinacrine [Wilson, W.D. &amp; Lopp, I.G. (1979) Biopolymers , 18 , 3025–3041]. Ethidium behaves, as a function of salt, as a monocation binding to DNA with neighbor exclusion and without ligand cooperativity. Equations are derived for two limiting kinetics models for intercalation involving binding of the intercalator to a preequilibrium, open state of DNA (model I) or binding form a preequilibrium externally associated state of the intercalator with DNA (model II). Model II gives the best fit to all of the kinetic results if it is assumed that the initial external interaction of the intercalator with DNA is similar to the exchange of free and condensed simple counterions. Intercalation then occurs from this state following an opening transition of the base pairs of the double helix. This model predicts a larger effect of salt concentration on the association than on the dissociation reaction, and that is what is experimentally observed. The intercalation conformational change makes a significant contribution to the ionic effects for both the equilibrium binding and the kinetic constants. The dissociation results and the association reaction results under pseudo‐first‐order conditions could be fit with single exponential curves under the conditions of our experiments.
Elevated Inflammatory Mediators in Adults with Oculorespiratory Syndrome following Influenza Immunization: a Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network Study (2013)

Oculorespiratory syndrome (ORS) is an infrequent adverse event following influenza vaccination. Its clinical presentation suggests that ORS is an immune-mediated phenomenon, but studies of symptomatic individuals have been few. This study measured cytokine levels in peripheral blood samples following influenza vaccination in those with and without current ORS symptoms. Canadian adults receiving the 2010-2011 seasonal influenza vaccine were recruited and asked to promptly report any adverse effects. ORS symptoms occurring 4 to 48 h after vaccination were identified using previously published criteria. Two blood samples were collected from each subject to measure blood plasma cytokine and hemagglutination inhibition antibody (HAI) titers; visit 1 occurred during the acute disease phase or 4 to 72 h after vaccination for controls, and visit 2 occurred another 21 days postimmunization. Nine ORS cases and 35 controls were enrolled. The median age of ORS cases was 49 years, and 89% were female. Most cases had multiple symptoms, but none required medical care. HAI titers before and after vaccination were similar for the cases and controls. Blood plasma cytokine concentrations did not differ between the ORS cases and controls for most cytokines measured (interleukin 4 [IL-4], IL-5, IL-10, IL-13, IL-1α, IL-8, tumor necrosis factor alpha [TNF-α], gamma interferon [IFN-γ], and IL-17A). However, ORS cases had higher levels of IL-10 and IL-3 than the controls at visits 1 and 2, even after all symptoms had subsided. Persistent higher levels of IL-10 and IL-3 in ORS cases suggest that host factors may have predisposed these individuals to develop ORS following influenza vaccination. Further investigations are warranted, as they might identify subjects who are at risk for ORS prior to vaccination.
Review: Recent Advances in Argatroban-Warfarin Transition in Patients With Heparin-induced Thrombocytopenia (2008)

Heparin-induced thrombocytopenia is a devastating, life-threatening, immune-mediated complication of therapy with unfractionated heparin, and less frequently, with low molecular weight heparin. Direct thrombin inhibitors are now standard therapy for the prevention of thrombosis in heparin-induced thrombocytopenia. Argatroban, a small synthetic molecule that inhibits thrombin at its active site, is increasingly used as the direct thrombin inhibitors of choice. Transition to longer term oral anticoagulation needs to be instituted after the platelet count has risen, because of the persistent risk of thrombosis. Although guidelines available in the literature outline the management of heparin-induced thrombocytopenia, they are not presented in a concise and comprehensive manner easily followed by physicians. This article reviews current recommendations, relevant studies, and clinical management trials carried out on patients with heparin-induced thrombocytopenia and provides updated, detailed guidelines for treatment of heparin-induced thrombocytopenia with emphasis on a key part of the management, the argatroban-warfarin transition.
Superconductivity in the family of organic salts based on the tetramethyltetraselenafulvalene (TMTSF) molecule: (TMTSF)2X (X=ClO4, PF6, AsF6, SbF6, TaF6) (1981)

International audience
Association of maintenance rituximab with clinical outcome in rituximab-naïve patients with Waldenstrom's macroglobulinemia (WM) who respond to a rituximab-containing regimen. (2010)

8107 Background: Rituximab alone and in combination is an important mainstay of therapy for WM. While maintenance rituximab (MRx) is often employed after induction therapy, its safety and efficacy has not been investigated in WM. Methods: We therefore investigated the outcome of 248 rituximab-naive WM patients who responded to a rituximab-based induction therapy, including 86 (35%) patients who then received MRx. No differences in baseline characteristics, and post-induction categorical responses were observed between cohorts. Induction therapy included rituximab alone (n=79) or in combination (n=169). The median rituximab infusions during induction was 6 for both cohorts; and 8 over a 2 year period for MRx treated patients. Results: With a median follow-up of 37.9 months, categorical response upgrade occurred in 16/162 (10%) versus 36/86 (41.8%) of observed and MRx treated patients, respectively (p<0.0001). The median PFS for MRx treated patients was 56.3 versus 28.6 months for observed patients (p=0.0001). Improved PFS was observed despite previous treatment status (p≤0.001); induction with rituximab alone (p=0.001), or in combination therapy (p=0.0001). Among patients receiving MRx therapy, the median OS was >120 months versus 116 months for patients who were observed (p=0.0095). Improved OS was observed despite previous treatment status (p≤0.001), induction with rituximab alone (p=0.083) or in combination (p=0.041). No difference in PFS and OS for patients was observed between patients who received MRx as 1 single infusion every 3 months versus 4 weekly infusions every 6 months (p=0.49 and 0.38, respectively). 20.4% and 38.4% of observed and MRx patients experienced at least 1 infectious event, respectively (p=0.0064). Most infections involved the sinus and pulmonary tracts; all but 6 of these events were (p = 0.718). Conclusions: MRx is well tolerated and associated with improved clinical outcomes in WM patients who respond to induction with a rituximab-containing regimen despite previous treatment status, treatment with rituximab alone, or in combination therapy. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Biogen Idec, Celgene, Genentech, Millennium Biogen Idec, Celgene, Millennium Celgene, Millennium
Nanopositioning With Multiple Sensors: A Case Study in Data Storage (2012)

The use of multiple sensors for nanopositioning is well motivated in high-density data-storage devices, such as probe-based data storage devices. In these devices, ultra-high positioning accuracies are desired over their lifetime in the presence of external disturbances. In addition to meeting the stringent requirements for nanopositioning, the use of multiple sensors lends itself for performing sensor fusion and obtaining reliable estimates of position and velocity. These estimates can be used for the detection of shocks and vibrations and the calibration of sensors. The objective of this work is to provide a comprehensive overview of the problem of nanopositioning using multiple sensors in the context of probe-based data storage. We present the control of a micro-scanner used in a probe-based data-storage device with two sensors, a global thermal position sensor and medium-derived positional information. In one approach, Kalman and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</sub> filtering are employed to perform sensor fusion, and the resulting state estimates in turn serve to design feedback controllers. An alternate approach is to design a multiple-input single-output controller using either the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> or <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</sub> control paradigm. These controllers are investigated in detail to reveal the underlying structure and the inherent sensor fusion that takes place. Comparisons are made between the two approaches.
Targeting Thrombomodulin to Endothelial ICAM-1 Rather Than PECAM-1 Allows Partnering with the Endothelial Protein C Receptor and Enhances Protection of Endothelial Barrier Function (2012)

Abstract Abstract 3351 The thrombomodulin-protein C pathway has important antithrombotic and anti-inflammatory roles in a variety of disease models and human illnesses, including severe sepsis, acute lung injury, and focal ischemia &amp; reperfusion. We recently reported that anchoring recombinant thrombomodulin (TM) to PECAM-1 on the luminal surface of the vascular endothelium is protective in a mouse model of inflammatory lung injury. To this point, it has been unclear whether targeted thrombomodulin is able to partner with the endothelial protein C receptor (EPCR) in the same way as its endogenous counterpart. Here we demonstrate that anchoring TM to endothelial ICAM-1, rather than PECAM-1, results in approximately 10-fold greater activation of protein C. Furthermore, blocking protein C binding to EPCR results in marked reduction of protein C activation when TM is targeted to ICAM-1, whereas protein C activation is largely independent of EPCR when PECAM-1 is used as the target ligand. Consistent with this in vitro observation, anti-ICAM/TM fusion protein provides greater in vivo protection in a mouse model of inflammatory lung injury than its PECAM-targeted analogue, more potently blocking expression of pro-inflammatory cytokines and more effectively stabilizing endothelial barrier function. Since ICAM, endogenous TM, and EPCR are all thought to localize to microdomains on the apical surface of endothelial cells, we hypothesize that ICAM-targeting more effectively mimics the natural configuration and brings TM within sufficient proximity to allow access to its membrane co-factor. These observations could have profound implications for the therapeutic efficacy of a whole series of endothelial-targeted proto-drugs and their potential for translational success. Disclosures: No relevant conflicts of interest to declare.
Bimetallic IrRh/CeO2–ZrO2 as a Highly Active Catalyst for NO–CO–C3H6–H2–O2 Reactions under Stoichiometric Conditions (2014)

Abstract The catalytic activity of Rh/CeO2–ZrO2 for NO–CO–C3H6–H2–O2 reactions under stoichiometric conditions was significantly improved by the addition of Ir. The optimum Ir/Rh atomic ratio was 1/9. The improvement was ascribed to the formation of finely divided Ir species on the surface of Rh particles. IrRh/CeO2–ZrO2 with an IrRh loading of 0.3 wt % showed high catalytic performance, which is comparable with that of 0.5 wt % Rh/CeO2–ZrO2, leading to minimize the Rh usage.
Caroviologens: Towards molecular wires (1992)

Bispyridinium conjugated polyenes of different lengths and charges have been synthesized. Since they combine the features of carotenoids and of viologens, they have been termed caroviologens. Such molecules, possessing an extended conjugated chain fitted with polar electroactive endgroups, and having a length sufficient to span a lipid membrane could function as transmembrane electron channels, i.e., as molecular wires.
Low-loss waveguides on Y-cut thin film lithium niobate: towards acousto-optic applications (2019)

We investigate the dependence of photonic waveguide propagation loss on the thickness of the buried oxide layer in Y-cut lithium niobate on insulator substrate to identify trade-offs between optical losses and electromechanical coupling of surface acoustic wave (SAW) devices for acousto-optic applications. Simulations show that a thicker oxide layer reduces the waveguide loss but lowers the electromechanical coupling coefficient of the SAW device. Optical racetrack resonators with different lengths were fabricated by argon plasma etching to experimentally extract waveguide losses. By increasing the oxide layer thickness from 1 µm to 2 µm, we were able to reduce propagation loss of 2 µm (1 µm) wide waveguide from 1.85 dB/cm (3 dB/cm) to as low as 0.37 dB/cm (0.77 dB/cm). Resonators with a quality factor greater than 1 million were demonstrated as well. An oxide thickness of approximately 1.5 µm is sufficient to significantly reduce propagation loss, due to leakage into the substrate and simultaneously attain good electromechanical coupling in acoustic devices. This work not only provides insights on the design and realization of low-loss photonic waveguides in lithium niobate, but also, most importantly, offers experimental evidence of how the oxide thickness directly impacts losses and guides its selection for the synthesis of high-performance acousto-optic devices in Y-cut lithium niobate on insulator.
On synchronization in an OFDM based UMTS proposal (1997)

In this paper we discuss three signal models and respective Maximum Likelihood estimators of time and frequency osets. We consider implementation structures for these estimators. Furthermore, we discuss the applicability of these estimators and some variants in a proposal for the future UMTS.
[Fundamental Evaluation and Clinical Usefulness of Lipoprotein Analysis System with Anion-Exchange Chromatography]. (2015)

We established a method for measurement of the cholesterol concentrations of high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), intermediate density lipoprotein cholesterol (IDL-C) and very low density lipoprotein cholesterol (VLDL-C) by using high performance liquid chromatography (HPLC) with anion-exchange column. The HPLC method has been covered by insurance in 2013, and HLC-729LPII (LPII) system constructed by this method has come on the market in 2014. We evaluated the fundamental precision data of lipoprotein cholesterol values measured by HLC-729 LPII. The within-day and between-day assay coefficients of variation of lipoprotein cholesterol values were 1.4-10.7 (%CV). The lipoprotein profiles of patients with type 2 diabetes mellitus (T2DM, n = 60) without dialysis therapy were measured by LPII. HDL-C obtained by LPII was highly correlated with that obtained by direct assay. LDL-C obtained by LPII was highly correlated with those obtained by direct assay and calculated by Friedewald's formula. In addition, IDL-C obtained by LPII was negatively correlated with estimated Glomerular Filtration Ratio (eGFR). These results suggest that the new HPLC method can be applied to estimate lipoprotein profile of T2DM patients. Particularly, IDL cholesterol may be useful for the evaluation of impaired lipid metabolism in T2DM patients without dialysis therapy, but it remains to be cleared.
Synthesis and characterization of tris(maleonitriledithiolato)metalates (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of tris(maleonitriledithiolato)metalatesE. I. Stiefel, Larry Everett Bennett, Z. Dori, T. H. Crawford, C. Simo, and Harry B. GrayCite this: Inorg. Chem. 1970, 9, 2, 281–286Publication Date (Print):February 1, 1970Publication History Published online1 May 2002Published inissue 1 February 1970https://pubs.acs.org/doi/10.1021/ic50084a020https://doi.org/10.1021/ic50084a020research-articleACS PublicationsRequest reuse permissionsArticle Views433Altmetric-Citations81LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Melting Characteristics and Hardness of Milkfat Blend Sucrose Polyesters (1994)

ABSTRACT Sucrose polyesters (SPE) are noncaloric fat substitutes prepared from fatty acid methyl esters (FAME) and sucrose. Our objectives were to determine and compare the effects of supplementing FAME from hydrolyzed milkfat with 25% FAME derived from beef tallow, coconut oil, or myristic acid on melting characteristics, hardness, and fatty acid profiles of SPE. DSC thermograms revealed different melting profiles among the SPE and anhydrous milkfat. Milkfat:tallow, milkfat:coconut, and milkfat SPE differed (p&lt;0.05) in hardness from milkfat at 12.5, 22, and 27.5°C. Fatty acid compositions of the SPE were also different. Adjustments of melting characteristics, hardness, and fatty acid substituents of SPE are essential when substituting milkfat SPE for selected natural fats in foods.
TALE and Shape: How to Make a Leaf Different (2013)

The Three Amino acid Loop Extension (TALE) proteins constitute an ancestral superclass of homeodomain transcription factors conserved in animals, plants and fungi. In plants they comprise two classes, KNOTTED1-LIKE homeobox (KNOX) and BEL1-like homeobox (BLH or BELL, hereafter referred to as BLH), which are involved in shoot apical meristem (SAM) function, as well as in the determination and morphological development of leaves, stems and inflorescences. Selective protein-protein interactions between KNOXs and BLHs affect heterodimer subcellular localization and target affinity. KNOXs exert their roles by maintaining a proper balance between undifferentiated and differentiated cell state through the modulation of multiple hormonal pathways. A pivotal function of KNOX in evolutionary diversification of leaf morphology has been assessed. In the SAM of both simple- and compound-leafed seed species, downregulation of most class 1 KNOX (KNOX1) genes marks the sites of leaf primordia initiation. However, KNOX1 expression is re-established during leaf primordia development of compound-leafed species to maintain transient indeterminacy and morphogenetic activity at the leaf margins. Despite the increasing knowledge available about KNOX1 protein function in plant development, a comprehensive view on their downstream effectors remains elusive. This review highlights the role of TALE proteins in leaf initiation and morphological plasticity with a focus on recent advances in the identification of downstream target genes and pathways.
Temperature‐Independent Hole Mobility of a Smectic Liquid‐Crystalline Semiconductor based on Band‐Like Conduction (2013)

A liquid-crystalline (LC) phenylterthiophene derivative, which exhibited an ordered smectic phase at room temperature, was purified by vacuum sublimation under a flow of nitrogen. During the sublimation process, thin plates with sizes of 1 mm grew on the surface of the vacuum tube. The crystals exhibited the same X-ray diffraction patterns as the ordered smectic phase of the LC state that was formed through a conventional recrystallization process by using organic solvents. Because of the removal of chemical impurities, the hole mobility in the ordered smectic phase of the vacuum-grown thin plates increased to 1.2×10(-1) cm(2) V(-1) s(-1) at room temperature, whereas that of the LC precipitates was 7×10(-2) cm(2) V(-1) s(-1). The hole mobility in the ordered smectic phase of the vacuum-sublimated sample was temperature-independent between 400 and 220 K. The electric-field dependence of the hole mobility was also very small within this temperature range. The temperature dependence of hole mobility was well-described by the Hoesterey-Letson model. The hole-transport characteristics indicate that band-like conduction affected by the localized states, rather than a charge-carrier-hopping mechanism, is a valid mechanism for hole transport in an ordered smectic phase.
A novel pattern of dimerization for 1, 4‐diphospha‐1,3‐butadienes (2003)

Abstract A new example of [2+4] cycloaddition of the low‐coordinated diphospha‐analog of butadiene protected with a 2,4‐di‐ tert ‐butyl‐6‐methylphenyl group has been described. X‐ray structure investigations of monomer 4b and dimer 5a have been reported for the first time. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:231–234, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10123
P(CH3NCH2CH2)3N:  A Nonionic Superbase for Efficient Dehydrohalogenation (1997)

The commercially available nonionic superbase P(CH3NCH2CH2)3N (1) is far superior to DBU for the conversion of primary and secondary alkyl halides to alkenes. A reason for the efficacy of acetonitrile as a solvent for the halides requiring extended reaction times is presented.