gebhart/patrepeval huggingface dataset:
Abstract 5805: Ebastine targets cancer stem cell-like properties and metastasis in triple-negative breast cancer by binding focal adhesion kinase (2023)

Abstract Triple-negative breast cancer (TNBC) exhibits an aggressive behavior associated with poor prognosis due to the absence of established molecular targets. Focal adhesion kinase (FAK) is a major determinant and participates in the acquisition of migration and invasion, as well as the maintenance of breast cancer stem cell (BCSC)-like traits in TNBC. We sought to investigate the effect of ebastine, a second-generation antihistamine on apoptosis, FAK activation, BCSC subpopulations and metastasis in TNBC in vitro and in vivo. TCGA dataset analysis revealed that mRNA levels of FAK were highly expressed in TNBC compared to other breast cancer subtypes. We found that ebastine binds to the tyrosine kinase domain of FAK, which blocks phosphorylation at the Y397 and Y576/577 residues and subsequent inactivation of SRC. Ebastine-induced apoptosis was associated with attenuation of JAK2/STAT3 and MEK/ERK signaling in TNBC cells. Kinetic analysis revealed a concentration-dependent impairment of cell migration in the presence of ebastine in MDA-MB-231 and 4T1 cells in vitro. Ebastine targets BCSC-like cell populations as evidenced by a sharp decline in the expression of the BCSC markers ALDH1, CD44 and CD49f and suppression of mammosphere-forming capacity. Ebastine administration led to a significant reduction in the growth ebastine of BCSC-enriched 4T1 mammospheres orthotopically injected into the mammary glands of Balb/c mice. Ebastine administration significantly impeded angiogenesis and distant metastasis while reducing MMP-2/-9 levels in circulating blood in vivo. Importantly, biochemical analysis in mice serum showed that ebastine had no effect on liver and kidney function. Our findings suggest that EBA may be an effective therapeutic repositioning candidate for the simultaneous targeting of multiple survival signaling pathways for the treatment of molecularly heterogeneous TNBC. Further investigation of ebastine as an anti-metastatic agent for the treatment of TNBC is warranted. Citation Format: Juyeon Seo, Minsu Park, Dongmi Ko, Seongjae Kim, Soeun Park, Kee Dal Nam, Yong Koo Kang, So Ra Seuk, Jaeyoun Park, Eunsun Jung, Yoon-Jae Kim, Ji Young Kim, Jae Hong Seo. Ebastine targets cancer stem cell-like properties and metastasis in triple-negative breast cancer by binding focal adhesion kinase. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5805.
Dynamic Non-Regular Sampling Sensor Using Frequency Selective Reconstruction (2018)

Both a high spatial and a high temporal resolution of images and videos are desirable in many applications, such as entertainment systems, monitoring manufacturing processes, or video surveillance. Due to the limited throughput of pixels per second, however, there is always a tradeoff between acquiring sequences with a high spatial resolution at a low temporal resolution or vice versa. In this paper, a modified sensor concept is proposed which is able to acquire both a high spatial and a high temporal resolution. This is achieved by dynamically reading out only a subset of pixels in a non-regular order to obtain a high temporal resolution. A full high spatial resolution is then obtained by performing a subsequent 3D reconstruction of the partially acquired frames. The main benefit of the proposed dynamic readout is that for each frame, different sampling points are available, which is advantageous since this information can significantly enhance the reconstruction quality of the proposed reconstruction algorithm. Using the proposed dynamic readout strategy, gains in the peak-signal-to-noise ratio (PSNR) of up to 8.55 dB are achieved compared with a static readout strategy. Compared with the other state-of-the-art techniques, such as frame rate up-conversion or super-resolution, which are also able to reconstruct sequences with both a high spatial and a high temporal resolution, average gains in PSNR of up to 6.58 dB are possible.
High bandwidth Ku-band Fabry-Perot cavity array antenna using FSS superstrate (2011)

This paper presents the simulation, design, fabrication, and measurement of a high-bandwidth Fabry-Perot cavity array antenna for the Ku-band. Starting with the design and analysis of one single feed antenna, that has a 3 dB realized gain bandwidth covering the satellite broadcast downlink band from 10.7 GHz to 12.75 GHz, an extension to a 3x3 array is presented.
Suppl. Figure S7 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma (2023)

&lt;p&gt;S7: Pathway enrichment (metabolomics)&lt;/p&gt;
Tagged Back-Translation (2019)

Recent work in Neural Machine Translation (NMT) has shown significant quality gains from noised-beam decoding during backtranslation, a method to generate synthetic parallel data. We show that the main role of such synthetic noise is not to diversify the source side, as previously suggested, but simply to indicate to the model that the given source is synthetic. We propose a simpler alternative to noising techniques, consisting of tagging back-translated source sentences with an extra token. Our results on WMT outperform noised back-translation in English-Romanian and match performance on English-German, re-defining state-of-the-art in the former.
Evaluation of Soybean Genotypes for Resistance to Three Seed-borne Diseases (2012)

Seed-borne diseases of soybeans caused by Phomopsis longicolla (Phomopsis seed decay), Cercospora kukuchii (purple seed stain), and M. phaseolina (charcoal rot) are economically important diseases that affect seed quality. Commercial cultivars marketed as resistant to all three diseases are not available. Reactions of 27 maturity group (MG) III, 30 early MG IV, 33 late MG IV, and 53 MG V genotypes were evaluated for resistance to these pathogens during the 2006 to 2008 growing season in the same field that had been in no-till production, not irrigated, and naturally and artificially infested. There was great variation in seed infection among genotypes and years, indicating the value of screening genotypes over multiple years. Some genotypes were resistant to these pathogens in one, two, or in all three years. Genotypes, DP 3478 (early MG IV), and RO1-769F (MG V) were resistant and DG4460 was moderately resistant to P. longicolla infection across three years. Genotypes AG3705 and FFR3990 (MG III) and DC20300, DC7816, Stoddard, and Ozark (MG V), were resistant to C. kukuchii infection during all three years. Ten genotypes in MG III, eight in early MG IV, seven in late MG IV, and 14 in MG V had no seed infection by M. phaseolina in all three years. These results indicate that seed infection comparison to these pathogens among genotypes should be made over several years, or false conclusions about resistance to any of the three pathogens may be made when disease is assessed for limited period of time. The genotypes identified as having resistance to each or combinations of the seed-borne diseases across the three years could be useful as a source for resistance in improving soybean seed quality. Accepted for publication 20 December 2012. Published 21 March 2012.
ChemInform Abstract: Synthesis of Strychnine via the Wieland‐Gumlich Aldehyde. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Parameter estimation for autoregressive Gaussian-mixture processes: the EMAX algorithm (1998)

The problem of estimating parameters of discrete-time non-Gaussian autoregressive (AR) processes is addressed. The subclass of such processes considered is restricted to those whose driving noise samples are statistically independent and identically distributed according to a Gaussian-mixture probability density function (pdf). Because the likelihood function for this problem is typically unbounded in the vicinity of undesirable, degenerate parameter estimates, the maximum likelihood approach is not fruitful. Hence, an alternative approach is taken whereby a finite local maximum of the likelihood surface is sought. This approach, which is termed the quasimaximum likelihood (QML) approach, is used to obtain estimates of the AR parameters as well as the means, variances, and weighting coefficients that define the Gaussian-mixture pdf. A technique for generating solutions to the QML problem is derived using a generalized version of the expectation-maximization principle. This technique, which is referred to as the EMAX algorithm, is applied in four illustrative examples; its performance is compared directly with that of previously proposed algorithms based on the same data model and that of conventional least-squares techniques.
Organometallic Compounds of the Lanthanides 182 [1]. Calcium and Neodymium Complexes Containing the dpp-BIAN Ligand System: Synthesis and Molecular Structure of [(dpp-BIAN)CaI(THF)2]2 and [(dpp-BIAN)NdCl(THF)2]2 (2007)

Oxydation of (dpp-BIAN)Ca(THF) 4 with 0.5 equiv. of I 2 in THF yields [(dpp-BIAN)CaI(THF) 2 ] 2 (1). A corresponding neodymium compound [(dpp-BIAN)NdCl(THF) 2 ] 2 (2) has been obtained by reaction of (dpp-BIAN)Na 2 with NdCl 3 in THF. The X-ray single crystal structure analyses show 1 and 2 to be isostructural dimers containing octahedrally coordinated metal atoms bridged by the respective halides. The chelating dpp-BIAN ligand acts as a radical anion in the Ca 2+ complex 1 and as a dianion in the Nd 3+ complex 2, respectively.
Experimental Investigation and Predictive Analysis of Propeller Tip Vortex Characteristics and its Interaction Noise (2023)

View Video Presentation: https://doi.org/10.2514/6.2023-3655.vid The findings of an experimental analysis of propeller wake and characterization of Tip Vortex as they developed downstream of a 2-bladed 16-inch propeller at hover condition are presented in this research. A detailed Hot-wire Anemometry measurements were performed in order to characterize the wake of the propeller. Ensemble averaging of the measured signals was performed at each measurement point. The tip vortecies were tracked, and their angular and spatial locations were identified along the axial distance from the propeller’s disc. A comparison between the existing analytical model for Tip Vortex evolution with experimental data is performed. The tip vortices are shown to travel to an axial distance of z/D = 0.2 while completing one full rotation. Axial instabilities occurred at z/D = 0.25 causing the two vortecies to merge. Strong attenuation of the spectral densities was observed downstream of the wake for all measured points across the blade’s radius. The Acoustic measurements of Tip Vortex-wing interactions and corresponding analytical model for broadband noise were performed and show that the Amiet model does to some extend predict the increase in the broadband noise between 100 Hz and 1 KHz.
Tailoring of the luminescence properties of a silver and zinc phosphate glass at the nanoscale (2010)

Fluorescent nanostructures have been written using a femtosecond laser in a glass below the diffraction limit. They are composed of silver clusters. The process enables writing and erasing infinite 3D features at the nanometric scale.
ChemInform Abstract: Envirocat EPZG as an Efficient Heterogeneous Catalyst for Thioacetalization of Carbonyl Compounds. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
MOCVD Growth and Characterization of GaN Films with Composite Intermediate Layer Buffer on Si Substrate (1999)

GaN thin films have been grown on Si(001) substrate with specially designed composite intermediate layers (CIL) consisting of an ultrathin amorphous silicon layer and a GaN/AlxGa1—xN multilayered buffer by low pressure metal-organic chemical vapor deposition (MOCVD). The improved film quality has been obtained from adjusting the parameters and redesigning the buffer layer structures. These were verified from different materials characterization measurements. XRD patterns showed strong and narrow (0002) and (0004) peaks of wurtzite phase GaN, and no cubic or other phase features. Room temperature photoluminescence showed strong GaN near band edge emission at 3.42 eV with almost no deep defect emission features to be detected from the improved quality films. Raman scattering and infrared spectroscopy exhibited phonon and lattice vibration modes characteristic of wurtzite GaN with no modes related to cubic or other structural phase. Scanning electron microscopy reveals the polycrystalline structure with large grain sizes near 2 μm in these films.
Personalized gene therapy locks out HIV, paving the way to control virus without antiretroviral drugs (2015)

In concept, a single infusion of genetically modified cells could potentially reduce the need for lifelong medication by providing long-term control over the virus (functional immunity). While the dream of completely eliminating viral reservoirs (sterilizing immunity) is appealing, this presents a significant additional hurdle and may not be necessary to improve long-term health. A single infusion, or a small number of infusions, of engineered cells may be shown in confirmatory clinical trials to produce a meaningful biologic effect. These techniques have implications for targeted gene therapy in HIV and other diseases.
Induction of Autoimmune Arthritis in HLA-DR4 (DRB1*0401) Transgenic Mice by Immunization with Human and Bovine Type II Collagen (1998)

Although associations between the expression of particular HLA genes and the susceptibility to specific autoimmune diseases has been known for some time, the role that these HLA molecules play in the autoimmune response is unclear. Through the establishment of a chimeric HLA-DR/I-E transgene, we have examined the function of the rheumatoid arthritis (RA) susceptibility allele HLA-DR4 (DRB1*0401) in presenting antigenic peptides derived from the model Ag, type II collagen (CII), and in mediating an autoimmune response. As a transgene, the chimeric DR4 molecule conferred susceptibility to an autoimmune arthritis induced by immunization with human CII or bovine CII. These mice developed an inflammatory, autoimmune arthritis that was similar both histologically and in severity to that previously described for the collagen-induced arthritis model. The DR4-mediated autoimmune arthritis was accompanied by T cell and B cell responses to both the immunogen and the autoantigen, murine CII. The DR4-restricted T cell response to human CII was focused on an immunodominant determinant within CII263-270 and a minor determinant within CII286-300, the same CII determinants recently identified for yet another RA susceptibility allele, HLA-DR1 (DRB1*0101). Thus these data demonstrate that, like HLA-DR1, HLA-DR4 is capable of binding peptides derived from human CII and therefore probably plays a role in the autoimmune response to human CII observed in RA patients.
Factor-induced Reprogramming and Zinc Finger Nuclease-aided Gene Targeting Cause Different Genome Instability in β-Thalassemia Induced Pluripotent Stem Cells (iPSCs) (2015)

The generation of personalized induced pluripotent stem cells (iPSCs) followed by targeted genome editing provides an opportunity for developing customized effective cellular therapies for genetic disorders. However, it is critical to ascertain whether edited iPSCs harbor unfavorable genomic variations before their clinical application. To examine the mutation status of the edited iPSC genome and trace the origin of possible mutations at different steps, we have generated virus-free iPSCs from amniotic cells carrying homozygous point mutations in β-hemoglobin gene (HBB) that cause severe β-thalassemia (β-Thal), corrected the mutations in both HBB alleles by zinc finger nuclease-aided gene targeting, and obtained the final HBB gene-corrected iPSCs by excising the exogenous drug resistance gene with Cre recombinase. Through comparative genomic hybridization and whole-exome sequencing, we uncovered seven copy number variations, five small insertions/deletions, and 64 single nucleotide variations (SNVs) in β-Thal iPSCs before the gene targeting step and found a single small copy number variation, 19 insertions/deletions, and 340 single nucleotide variations in the final gene-corrected β-Thal iPSCs. Our data revealed that substantial but different genomic variations occurred at factor-induced somatic cell reprogramming and zinc finger nuclease-aided gene targeting steps, suggesting that stringent genomic monitoring and selection are needed both at the time of iPSC derivation and after gene targeting.
Tissue distribution of CD6 and CD6 ligand in cattle: expression of the CD6 ligand (CD166) in the autonomic nervous system of cattle and the human (2001)

We studied the tissue distribution of CD6(+) lymphocytes and cells expressing the CD6 ligand (also known as activated leukocyte cell adhesion molecule CD166) in calves by immunohistochemistry using an anti-bovine CD6 monoclonal antibody (mAb), a human CD6 (huCD6)-immunoglobulin G1 fusion protein (huCD6-Ig), and an anti-human CD166 (anti-huCD166) mAb. The huCD6-Ig and anti-huCD166 mAb bound to the sympathetic and parasympathetic nerve fibers but not to myelinated nerve fibers in the spinal nerve. Studies with human tissue using the anti-huCD166 mAb yielded identical patterns of labeling. Dense accumulations of CD6(+) lymphocytes were present in areas of the thymuses and spleens of calves, in areas innervated by huCD6-Ig(+) nerves. The cDNAs encoding the bovine CD166 and CD6 were isolated from the sympathetic ganglion and spleen, respectively. Predicted amino acid residues that are important for human and mouse CD6-CD166 binding were also conserved in bovine CD6 and CD166. Bovine CD166 transcripts were detected by reverse transcriptase-PCR in all the tissues that bound huCD6-Ig. These results show that the bovine orthologue of CD166 was constitutively expressed in the autonomic nervous systems of cattle and suggest that CD6(+) lymphocytes adhere to CD166(+) autonomic nerve terminals via CD6.
The design and implementation of Grid database services in OGSA‐DAI (2005)

Abstract Initially, Grid technologies were principally associated with supercomputer centres and large‐scale scientific applications in physics and astronomy. They are now increasingly seen as being relevant to many areas of e‐Science and e‐Business. The emergence of the Open Grid Services Architecture (OGSA), to complement the ongoing activity on Web Services standards, promises to provide a service‐based platform that can meet the needs of both business and scientific applications. Early Grid applications focused principally on the storage, replication and movement of file‐based data. Now the need for the full integration of database technologies with Grid middleware is widely recognized. Not only do many Grid applications already use databases for managing metadata, but increasingly many are associated with large databases of domain‐specific information (e.g. biological or astronomical data). This paper describes the design and implementation of OGSA‐DAI, a service‐based architecture for database access over the Grid. The approach involves the design of Grid Data Services that allow consumers to discover the properties of structured data stores and to access their contents. The initial focus has been on support for access to Relational and XML data, but the overall architecture has been designed to be extensible to accommodate different storage paradigms. The paper describes and motivates the design decisions that have been taken, and illustrates how the approach supports a range of application scenarios. The OGSA‐DAI software is freely available from http://www.ogsadai.org.uk . Copyright © 2005 John Wiley &amp; Sons, Ltd.
An optimized proportionate adaptive algorithm for sparse system identification (2015)

Proportionate-type adaptive algorithms are commonly used for the identification of sparse impulse responses, like in network and acoustic echo cancellation. In this paper, we propose an optimized proportionate LMS adaptive filter in the context of a state variable model. The algorithm follows an optimization criterion based on the minimization of the system misalignment and uses an iterative procedure for computing the proportionate factors. Consequently, it achieves a proper compromise between the performance criteria, i.e., fast convergence/tracking and low misadjustment. Simulations performed in the context of sparse system identification indicate the good behavior of the proposed algorithm.
1‐(Alkyl/Arylthiocarbamoyl)benzotriazoles as Stable Isothiocyanate Equivalents: Synthesis of Di‐ and Trisubstituted Thioureas. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Optical tank circuits used for all-optical timing recovery (1992)

A novel all-optical timing-recovery scheme that uses an optical tank circuit is presented. An optical clock synchronized to an incoming data stream is generated by extracting line spectral components in the incoming data stream using an optical resonator whose free spectral range is equal to the incoming data bit rate. The principle of operation is demonstrated using a confocal Fabry-Perot-type optical tank circuit and a fiber-ring-type optical tank circuit at 2 Gb/s and 324 Mb/s, respectively. Quality factor in the baseband domain is measured and shown to agree well with the theoretical value. A workable data bit rate, required source linewidth, and stability are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>