gebhart/patrepeval huggingface dataset:
Inhibition of BET Bromodomain Proteins with GS-5829 and GS-626510 in Uterine Serous Carcinoma, a Biologically Aggressive Variant of Endometrial Cancer (2018)

<b>Purpose:</b> Uterine serous carcinoma (USC) is a rare and aggressive variant of endometrial cancer. Whole-exome sequencing (WES) studies have recently reported c-Myc gene amplification in a large number of USCs, suggesting c-Myc as a potential therapeutic target. We investigated the activity of novel BET bromodomain inhibitors (GS-5829 and GS-626510, Gilead Sciences Inc.) and JQ1 against primary USC cultures and USC xenografts.<b>Experimental Design:</b> We evaluated c-Myc expression by qRT-PCR in a total of 45 USCs including fresh-frozen tumor tissues and primary USC cell lines. We also performed IHC and Western blot experiments in 8 USC tumors. USC cultures were evaluated for sensitivity to GS-5829, GS-626510, and JQ1 <i>in vitro</i> using proliferation, viability, and apoptosis assays. Finally, the <i>in vivo</i> activity of GS-5829, GS-626510, and JQ1 was studied in USC-ARK1 and USC-ARK2 mouse xenografts.<b>Results:</b> Fresh-frozen USC and primary USC cell lines overexpressed c-Myc when compared with normal tissues (<i>P</i> = 0.0009 and 0.0083, respectively). High c-Myc expression was found in 7 of 8 of primary USC cell lines tested by qRT-PCR and 5 of 8 tested by IHC. <i>In vitro</i> experiments demonstrated high sensitivity of USC cell lines to the exposure to GS-5829, GS-626510, and JQ1 with BET inhibitors causing a dose-dependent decrease in the phosphorylated levels of c-Myc and a dose-dependent increase in caspase activation (apoptosis). In comparative <i>in vivo</i> experiments, GS-5829 and/or GS-626510 were found more effective than JQ1 at the concentrations/doses used in decreasing tumor growth in both USC-ARK1 and USC-ARK2 mouse xenograft models.<b>Conclusions:</b> GS-5829 and GS-626510 may represent novel, highly effective therapeutics agents against recurrent/chemotherapy-resistant USC-overexpressing c-Myc. Clinical studies with GS-5829 in patients with USC harboring chemotherapy-resistant disease are warranted. <i>Clin Cancer Res; 24(19); 4845-53. ©2018 AACR</i>.
Epitaxial Growth of High Quality GaN Films on Lattice Matched Metallic Layers (2015)

We discuss the development of high-quality ZrTi metal layers that are epitaxially deposited by sputtering on sapphire and Si, and which are c-axis oriented and lattice matched for growth of low-defect hexagonal GaN films. We also explain and discuss the nucleation and growth of thick GaN layers by molecular beam epitaxy (MBE) and metal organic chemical vapor deposition (MOCVD) on these metal layers. Finally, we present the results of thin-film measurements to demonstrate the high crystal qualities and very smooth surface morphologies of highly specular GaN layers grown on ZrTi buffers in this work.
P3B-6 A Novel US Method for the Assessment of Maternal, Placental and Fetal Circulation during Pregnancy (2006)

Doppler ultrasound (US) techniques are widely used in diagnostics to evaluate the maternal and fetal hemodynamics. Most of these studies involve the assessment of the blood flow in the fetal aorta, umbilical artery, and the uteroplacental circulation. The analysis is typically limited to the echoes originated from a sample volume (SV) covering the whole section of the vessel. Both the shape of the resulting sonogram and the corresponding quantitative indexes (e.g. PI, S/D and RI), have been proven to be relevant for diagnostic purposes and, in particular, to predict possible pregnancy complications. In this paper we propose the application of a method named multigate Spectral doppler analysis (MSDA), to improve the hemodynamic assessment in maternal and fetal circulation. In MSDA, the Doppler data from 128 SVs, aligned along an US scan line that intercepts the vessel, are independently analysed to produce high resolution velocity profiles. In the present study, the MSDA approach has been applied to 36 volunteers. Some example of flow profile extracted from maternal and fetal circulation is presented and the potentiality of the MSDA method to characterize the blood flow configurations is discussed
Incidence du genre et du mentor sur la production scientifique et la carrière des psychologues : la perspective de la psychosociologie de la science (1996)

Le mentoring, par lequel la formation et (souvent) la carrière future d’un novice sont placées entre les mains d’un «mentor », est examiné dans une perspective plus vaste de «psychosociologie de la science» (Lubek, 1993a ; 1995), perspective qui étudie les relations de pouvoir asymétriques au sein de la communauté scientifique. Nous évoquons d’abord différentes études de cas pour illustrer ce cadre général : a) un examen des problèmes de publication rencontrés par le psychologue américain John Garcia ; b) une comparaison transculturelle du financement accordé aux pionniers de la recherche en sciences sociales français et à leurs homologues nord-américains dans les années 1920 et 1930 ; et c) un cas d'abus lié à la concentration du pouvoir de décision scientifique entre les mains d*un individu, et en particulier son incidence sur les femmes. Puis, nous passons à : d) une étude sur le mentoring de 285 hommes et 53 femmes psychosociologues ayant obtenu leur doctorat entre 1949 et 1974 à l’université de Michigan, dont le Joint Social Psychology Programme a été le plus important d’Amérique du Nord et a formé nombre des psychosociologues les plus renommés. Nous examinons les effets de ce mentoring et des différences de genre sur le parcours professionnel et la production scientifique, en nous servant essentiellement d’indicateurs macroscopiques quantitatifs permettant de comparer la carrière des 53 femmes avec celle d’un nombre équivalent d’hommes ayant eu le même mentor, au même moment.
Sleep and breathing (1994)

of Sleep, Dennis McGinty and Ronald Szymusiak Brainstem and Forebrain Regulation of Sleep Onset and Slow-Wave Sleep, Ronald Szymusiak and Dennis McGinty The Neurobiology of Rapid-Eye-Movement Sleep, Ralph Lydic and Helen A. Baghdoyan Sleep Factors, James M. Krueger and Ferenc Obal Jr. The Wakefulness Stimulus for Breathing, John Orem Periodic Breathing During Sleep, Neil S. Cherniack and Guy Longobardo The Human Airway During Sleep, David W. Hudgel and Paul M. Suratt The Thoracic Pump During Sleep: An Overview of Respiratory Muscle Function with Emphasis on Aspects of Measurement, Michael D. Goldman, Claude Gaultier, Pierre Escourrou, and Jean-Paul Cantineau The Influence of Sleep on Respiratory Muscle Function: Interactions Between Upper Airway and Chest Wall Muscles, Barbara Gothe, Erik van Lunteren, and Thomas E. Dick Influence of Sleep State and Sleep-Disordered Breathing on Cardiovascular Function, Thomas Podszus, Harly Greenberg, and Steven M. Scharf Epidemiology as a Research Tool in Breathing Disorders of Sleep, Terry Young Prevalence of Snoring, Elio Lugaresi and Markku Partinen Familial Influences on Sleep Apnea, Susan Redline and Peter V. Tishler Portable Monitoring of Sleep and Breathing, JOrg Herman Peter and Thomas Penzel Pathophysiology of Sleep Apnea, Peter A. Cistulli and Colin E. Sullivan Endocrine and Metabolic Disturbances in Obstructive Sleep Apnea, Ron Grunstein Clinical Aspects of Sleep Apnea, Stephen G. McNamara, Peter A. Cistulli, Kingman P. Strohl, and Colin E. Sullivan Controversies in the Treatment of Snoring and Obstructive Sleep Apnea, Philip R. Westbrook and Richard P. Millman Mortality and Morbidity of Obstructive Sleep Apnea Syndrome: Prospective Studies on Retrospective Cohorts, Christian Guilleminault, Markku Partinen, Meir Kryger, and Riccardo Stoohs Investigation and Management of Daytime Sleepiness in Sleep Apnea, Nancy Barone Kribbs, Joanne E. Getsy, and David F. Dinges Regulation of Breathing in the Fetus and the Newborn, David J. Henderson Smart Apnea and the Sudden Infant Death Syndrome, Bradley T. Thach Sleep and Breathing in the Elderly, Sonia Ancoli-Israel, Donald Bliwise, and Andrea Mant Breathing During Sleep in Chronic Obstructive Pulmonary Disease, Neil J. Douglas Sleep and Breathing in Asthma, Cystic Fibrosis, and Interstitial Lung Disease, Antonio Ambrogetti, Leslie G. Olson, and Michael J. Hensley Sleep-Disordered Breathing in Neuromusclular Disease, Amanda J. Piper and Colin E. Sullivan Breathing During Sleep in Cardiac Disease, T. Douglas Bradley Speculations on the Interaction Between Vascular Disease and Obstructive Sleep Apnea, Jan A. Hedner, Ian Wilcox, and Colin E. Sullivan Animal Models of Sleep Apnea, Joan C. Hendricks and Allan I. Pack
Association analysis of the surfactant protein-C gene to childhood asthma (2020)

In Tunisia, this work constitutes the first report interested in the <i>SFTPC</i> gene and highlights the genetic variability of the <i>SFTPC</i> gene in asthma. Therefore, the case-controls analysis may be useful in the study of surfactant proteins dysfunction in chronic respiratory disease at an early age.
Performance of a PET Detector With a 256ch Flat Panel PS-PMT (2004)

A 256ch flat panel position sensitive photomultiplier tube (FP-PMT) is a promising device for a PET detector because of its large opening area, 52 mm /spl times/ 52 mm, and small dead space. The useful area of the 256ch FP-PMT is 89% to the opening area. The 256ch FP-PMT contains 16 /spl times/ 16 matrix anodes with 3.04 mm intervals between them so that the 256ch FP-PMT affords optical coupling with a 16 /spl times/ 16 array of scintillation crystals having 3 mm /spl times/ 3 mm bottom area. Its 14.7 mm thickness will also ensure a compact volume and less weight for the PET apparatus. Using a prototype 256ch FP-PMT, we measured light spread function of a central anode and crystal identification ability with 2.9 mm /spl times/ 2.9 mm /spl times/ 7.5 mm Gd/sub 2/SiO/sub 5/ (GSO) crystals. The full width at half maximum of the light spread function was found to be 4.6 mm. As regards positioning performance, the resultant positioning image map assures its capability for crystal identification in a 16 /spl times/ 16 array of the GSO crystals. For the use of a 256ch FP-PMT having a large useful area, we made a new proposal for easier construction of an array with many crystal elements. The way utilizing multilayer polymer mirrors, a reflector, properly processed by laser can be applied to other various shaped detectors.
Monodisperse particle production by vapor condensation in nozzles (1988)

When a gas containing a condensable vapor expands from a reservoir through a subsonic or supersonic nozzle, the gas is cooled and the vapor can condense to form particles. A theoretical framework to describe such systems is given. Calculations based on the theory show that approximately uniform submicrometer particles can be produced at high mass rates by subsonic nozzle expansion. Four operating conditions (exit Mach number and the reservoir temperature, pressure, and saturation ratio) and the nozzle shape (area distribution and length) control the spread of the particle size distribution. Two modes of nozzle operation are predicted. In one case nucleation is confined to the nozzle while in the other case nucleation occurs both in the nozzle contraction and in a straight section following the nozzle. Nearly monodisperse particles can be produced for a wide range of operating conditions for both types of nozzle operation. Particle properties are less sensitive to operating conditions, however, when the conditions are chosen so that nucleation is confined to the nozzle.
Low-loss, single-model optical phase modulator in SIMOX material (1994)

This paper reports results of the simulation of an optical phase modulator. The proposed modulator consists of an elongated p-i-n structure fabricated in a silicon-on-insulator material such as SIMOX. It utilizes the free-carrier effect to produce the desired refractive index change in a single-mode optical rib waveguide. The MEDICI two-dimensional semiconductor device simulation package has been employed to optimize the overlap between the injected free carriers and the propagating optical guided mode. Although the device is designed to support a single optical guided mode, it measures several micrometers in cross-sectional dimensions, thereby simplifying fabrication and allowing efficient coupling to/from other single-mode devices. Furthermore, the device has an extremely high figure of merit, predicting over 200/spl deg/ of induced phase shift per volt per millimeter, as well as a low drive current of less than 10 mA. This is approximately an order of magnitude lower than most other reported devices in silicon.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Multivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell‐Wall Hydrolysis (2008)

Dendritische Zellwandmimetika: Cholin bindende Proteine aus Streptococcus pneumoniae erkennen unterschiedliche Cholin-Architekturen auf bakteriellen Zellwänden. Cholinfunktionalisierte Dendrimere hemmen diese lebenswichtigen Enzyme stark, und mit einer 103- bis 104-fach höheren Affinität als freies Cholin: So werden Autolyse und Zelltrennung in Bakterienkulturen durch Konzentrationen im niedrigen mikromolaren Bereich inhibiert (siehe Bild). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Effect of silicon (Si) and aluminium (Al) doping on material's hardness and oxidation resistance behaviours of chromium nitride (CrN) coatings: A NEXAFS investigation (2013)

Nowadays scientists and technologists are prompted to design and test novel coatings that can prevent mechanical damage to jet engines due to intrusion of airborne fine particulates, especially volcanic ash. Chromium nitride (CrN) is a prominent candidate, which can be engineered onto the surface of metals as a protective layer to enhance mechanical performances and durability of coated metals. Doped CrNs have widespread applications as protective coatings, including volcanic ash resistant coatings for jet engines. Excellent mechanical and chemical properties prevent these materials from wearing under harsh conditions. Previous investigations indicate that the mechanical hardness and oxidation resistance characteristics of the CrN coatings improved extensively with additional doping contents of silicon (Si) or aluminium (Al) to the CrN frame. In the present investigation, doped Cr (Si/Al) N coatings were prepared on steel substrates using a TEER UDP 650/4 closed field unbalanced magnetron sputtering technique. The Si and Al doping contents added were at 14.3, 21.2 and 28.5 at %, respectively. Synchrotron radiation near-edge X-ray absorption fine structure (NEXAFS) measurements were carried out in order to understand the local bonding structure and grain boundaries of the coating. The NEXAFS measurements were conducted at Al K-edge, S K-edge, Cr L-edge in Auger electron yield (AEY) and total fluorescence yield (TFY) modes. These provided significant information on the electronic structures and the bonding states of CrN matrix with Al and Si doping that assist understanding of the effects of local bonding states and grain boundaries of CrN frame in relation to the mechanical strength and oxidation resistance of the coatings. The data presented here will provide valuable insights on the local structures of dopants in relation to the material’s properties, leading to the development of superhard and corrosion-resistant coatings.
Carbon dioxide-soluble polymers and swellable polymers for carbon dioxide applications (2008)

A method for carrying out a catalysis reaction in carbon dioxide comprising contacting a fluid mixture with a catalyst bound to a polymer, the fluid mixture comprising at least one reactant and carbon dioxide, wherein the reactant interacts with the catalyst to form a reaction product. A composition of matter comprises carbon dioxide and a polymer and a reactant present in the carbon dioxide. The polymer has bound thereto a catalyst at a plurality of chains along the length of the polymer, and wherein the reactant interacts with the catalyst to form a reaction product.
Hydrophobically modified poly(vinyl alcohol) using alkoxy‐substituted methyl gallate: Synthesis and rheology (2010)

Abstract Hydrophobically modified poly(vinyl alcohol) (HMPVA) polymers were synthesized by potassium t ‐butoxide‐catalyzed reaction of PVA with methyl 3,4,5‐tris( n ‐octyloxy) benzoate (MGC 8 )/3,4,5‐tris( n ‐dodecyloxy) benzoate (MGC 12 ) and 1,3‐propane sultone. The concentration of 1,3‐propane sultone was kept constant at 10 mol % and that of MGC 8 (2, 3, and 4 mol %)/MGC 12 (2 and 3 mol %) was varied to obtain HMPVAs with different hydrophobic contents. The incorporation of MGC 8 /MGC 12 and 1,3‐propane sultone onto HMPVA was confirmed by NMR spectroscopy. Rheological properties of aqueous solutions also confirmed the presence of hydrophobic and charged functional groups on HMPVAs. In the semidilute regime, the specific viscosity of HMPVAs followed concentration scaling that is typical of polyelectrolytes. At higher concentrations, the HMPVA solutions with 3 and 4 mol % of MGC 8 exhibited large increase in specific viscosity. Oscillatory experiments on these solutions exhibited gel‐like behavior at polymer concentrations of 40–50 g/L. Confocal microscopy images of HMPVA with 4 mol % of MGC 8 clearly indicated the existence of microgels. The tendency of formation of microgels further increased with increasing chain length of the hydrophobe, that is, with MGC 12 . These samples exhibited rheological behavior that is typical of soft solids and was therefore probed by the strain‐rate frequency superposition technique reported recently in the literature. HMPVAs with improved rheological properties show potential applications as thickeners in cosmetic creams, lotions and as drug carriers in pharmaceutical formulations. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48: 1054–1063, 2010
[Recent findings on the pathogenesis and therapy of prostatic cancer]. (1988)

Presently, there is no effective therapy for increasing survival of metastatic prostatic cancer. New approaches to this major disease are, therefore, urgently needed. One approach is to study the biology of prostatic carcinogenesis in order to develop a therapeutic modality to prevent the development of clinically manifest prostatic cancer. Based upon international epidemiological data, it should be possible to lower the incidence of clinical prostatic cancer by more than 10-fold among the males of the western industrial states. An alternative approach is to study the tumor biology of prostatic cancer in order to identify new modalities to better treat already established clinical prostatic cancer. Such studies have already demonstrated that individual prostatic cancers are composed of clones of cancer cells which are phenotypically heterogeneous even before therapy is initiated. Due to this tumor cell heterogeneity, the direction of future studies should be towards combining androgen ablation plus chemotherapy early in the disease in order to affect both the androgen-dependent and -independent cancer cells present within individual prostatic cancers.
Performance analysis of the IEEE 802.16e mesh extension (2006)

info:eu-repo/semantics/published
ChemInform Abstract: 4‐Amino‐2‐(substituted methyl)‐2‐butenoic Acids: Substrates and Potent Inhibitors of γ‐Aminobutyric Acid Aminotransferase. (1986)

Abstract Ausgehend von dem geschützten γ‐Aminobuttersäureester (I) werden die im Titel genannten Verbindungen (V) synthetisiert.
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases (2016)

The hypoxia-inducible factor (HIF) system orchestrates cellular responses to hypoxia in animals. HIF is an α/β-heterodimeric transcription factor that regulates the expression of hundreds of genes in a tissue context-dependent manner. The major hypoxia-sensing component of the HIF system involves oxygen-dependent catalysis by the HIF hydroxylases; in humans there are three HIF prolyl hydroxylases (PHD1-3) and an asparaginyl hydroxylase (factor-inhibiting HIF (FIH)). PHD catalysis regulates HIFα levels, and FIH catalysis regulates HIF activity. How differences in HIFα hydroxylation status relate to variations in the induction of specific HIF target gene transcription is unknown. We report studies using small molecule HIF hydroxylase inhibitors that investigate the extent to which HIF target gene expression is induced by PHD or FIH inhibition. The results reveal substantial differences in the role of prolyl and asparaginyl hydroxylation in regulating hypoxia-responsive genes in cells. PHD inhibitors with different structural scaffolds behave similarly. Under the tested conditions, a broad-spectrum 2-oxoglutarate dioxygenase inhibitor is a better mimic of the overall transcriptional response to hypoxia than the selective PHD inhibitors, consistent with an important role for FIH in the hypoxic transcriptional response. Indeed, combined application of selective PHD and FIH inhibitors resulted in the transcriptional induction of a subset of genes not fully responsive to PHD inhibition alone. Thus, for the therapeutic regulation of HIF target genes, it is important to consider both PHD and FIH activity, and in the case of some sets of target genes, simultaneous inhibition of the PHDs and FIH catalysis may be preferable.
Limits in FIR subband beamforming for spatially spread near-field speech sources (2003)

This paper analyses optimal subband beamforming performance mainly aimed at speech enhancement and acoustic echo suppression for personal communication devices, personal computers and wireless cellular telephones. The focus is on theoretical limits of finite impulse response (FIR) beamformers for spatially spread sources in the array near-field. Performance of the Wiener solution is compared to the direct maximization of the array gain for different lengths of the FIR filters and different source interference spreads. The evaluation is performed individually in subbands with constant increasing logarithmic bandwidth. Results show that the difference between the Wiener solution and the direct array gain maximization is less than 2 dB in the measure of Signal-to-Noise plus Interference Ratio (SNIR), for small interference spread. With increasing interference spread the difference in SNIR performance increases, in favor of the array gain maximization.
ChemInform Abstract: Efficient 1,2‐Asymmetric Induction in Radical Reactions: Stereoselective Radical Addition to 3‐Hydroxy‐1‐(methylthio)‐1‐(p‐ tolylsulfonyl)‐1‐alkenes. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.