gebhart/patrepeval huggingface dataset:
Apprentissage pour la navigation robotique parmi les humains : vers des chemins s'adaptant aux dynamiques de l'environnement (2022)

La navigation robotique en milieu peuplé est un champ de recherche très actif depuis de nombreuses années. De nouvelles perspectives sont offertes grâce à l’essor de l’apprentissage par renforcement profond. On peut retrouver deux types d’approches dans la littérature. D’un côté, une approche réaliste du point de vue robotique, où le robot apprend une politique de contrôle à partir des données bruitées fournies par ses capteurs. De l’autre, une approche symbolique, où le robot possède une perception complète des positions et vitesses des agents de l’environnement.On laisse de côté le problème de vision et de représentation du monde physique, pour se concentrer sur la meilleure manière de convertir la perception en action. Le modèle DS-RNN est un bon exemple de cette dernière approche. Mais ses performances diminuent dans des conditions plus réalistes. La limitation du champs de vision et la présence d’obstacles statiques dans l’environnement affectent grandement son taux de succès. L’indifférenciation entre humain et obstacle semble en être la cause principale, nous avons donc proposé de multiples modifications d’architectures pour palier à ce problème.
The Effect of Pulsed Current on the Performance of Lithium-ion Batteries (2020)

The pulsed current is considered to improve the performance of the Lithium-ion (Li-ion) battery. However, the effect of the pulsed current on Li-ion battery performances is inconclusive at present. In this paper, a battery cell was charged by applying a 0.05 Hz pulsed current. Different duty cycles, the current-rates (C-rates), and ambient temperatures were considered in order to obtain a clear impact of the pulsed current on the battery performance during charging. Compared with the constant current, the pulsed current can improve the charging capacity and decrease the maximum rising temperature by 30.63% and 60.3%, respectively. The results obtained were used for the parameterization of a capacity model and charging time model, which are able to express both the capacity and charging time at different charging conditions of the Li-ion battery cell.
Chemical Mechanical Polishing with Nanocolloidal Ceria Slurry for Low-Damage Planarization of Dielectric Films (2012)

New chemical mechanical polishing processes using nanocolloidal ceria slurry are proposed for high-precision and low-damage planarization of silicon-dioxide-based dielectric films. In the polishing process of a shallow trench isolation structure, a hard pad and a cationic polymer additive are used in combination with the slurry. The new process is effective in improving the planarity and reducing the microscratch count in comparison with a conventional polishing process with calcined ceria slurry and a standard pad. In the polishing process of an interconnect structure with ultralow- k interlayer dielectrics (ULK-ILDs), the standard pad should be used since the ULK-ILDs are easily damaged. By employing a spin-on-type ULK-ILD having a self-planarizing effect, a high planarity is obtained when using the nanocolloidal ceria slurry with the standard pad. The electrical measurement of the interconnect structure indicates that dielectric damage due to the process is successfully suppressed.
Auroral plasma dynamics in the presence of a finite-width current filament and V-shaped potential drop (1995)

Introduction The Model Simulation Results Discussions
Force-assemblability: insertion of a workpiece into a fixture guided by contact forces alone (2002)

The authors describe the concept of force-assemblability, which may be applied to fixture insertion as well as other assembly tasks. They define a linear force assemblable fixture to be one for which there exists a linear motion control law (examples of which include compliance and accommodation) which necessarily results in workpiece contact with all fixture elements (fixels) despite initial positional error. For reliable insertion, the fixture should have the property that contact with all fixels insures a unique workpiece position (i.e. the fixture should be deterministic) and the property that, after the inserting motion terminates, contact with all fixels is insured. It is shown that all deterministic fixtures are force-assemblable when friction is less than some value dictated by the workpiece/fixture geometry. It is also shown how to generate a motion control law that satisfies force-assemblability at this value of friction.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Spatially Propagating Biochemical Reaction (2010)

Surfen mit der Kinase: Eine lösliche Kinase phosphoryliert ein immobilisiertes Peptidsubstrat am schnellsten an der Grenze zwischen Produkt und Substrat, sodass eine „Welle“ der Produktbildung entsteht (siehe Bild). Solche Systeme bieten die Möglichkeit eines räumlich und zeitlich kontrollierten Reaktionsfortschritts.
Identification and application of a DNA‐based marker that is diagnostic for the pepper (Capsicum annuum) bacterial spot resistance gene Bs3 (2010)

With 1 figure and 1 table Abstract The pepper ( Capsicum annuum ) disease resistance gene Bs3 mediates recognition of avrBs3 ‐expressing strains of the bacterial spot pathogen Xanthomonas campestris pv. vesicatoria . We established the co‐dominant DNA marker PR‐Bs3 that detects a functional nucleotide polymorphism in the Bs3 promoter. Analysis of 20 F 2 segregants demonstrated complete linkage between PR‐Bs3 and Bs3 resistance. Furthermore the analysis of 17 Capsicum accessions from diverse geographical origins demonstrated that PR‐Bs3 was diagnostic for Bs3 resistance in all cases. Given that marker PR‐Bs3 allows the identification of Bs3 resistant lines in a co‐dominant fashion it will be a valuable tool for marker assisted selection of Bs3 resistant lines in bacterial spot resistance breeding programs.
Controlled loading of cryoprotectants (CPAs) to oocyte with linear and complex CPA profiles on a microfluidic platform (2011)

Oocyte cryopreservation has become an essential tool in the treatment of infertility by preserving oocytes for women undergoing chemotherapy. However, despite recent advances, pregnancy rates from all cryopreserved oocytes remain low. The inevitable use of the cryoprotectants (CPAs) during preservation affects the viability of the preserved oocytes and pregnancy rates either through CPA toxicity or osmotic injury. Current protocols attempt to reduce CPA toxicity by minimizing CPA concentrations, or by minimizing the volume changes via the step-wise addition of CPAs to the cells. Although the step-wise addition decreases osmotic shock to oocytes, it unfortunately increases toxic injuries due to the long exposure times to CPAs. To address limitations of current protocols and to rationally design protocols that minimize the exposure to CPAs, we developed a microfluidic device for the quantitative measurements of oocyte volume during various CPA loading protocols. We spatially secured a single oocyte on the microfluidic device, created precisely controlled continuous CPA profiles (step-wise, linear and complex) for the addition of CPAs to the oocyte and measured the oocyte volumetric response to each profile. With both linear and complex profiles, we were able to load 1.5 M propanediol to oocytes in less than 15 min and with a volumetric change of less than 10%. Thus, we believe this single oocyte analysis technology will eventually help future advances in assisted reproductive technologies and fertility preservation.
microRNA Involvement in Hepatocellular Carcinoma (2011)

The role of microRNAs (miRNAs) in human tumorigenesis has been demonstrated by gene profiling and functional studies. In hepatocellular carcinoma (HCC), consistently deregulated miRNAs were identified. Their aberrant expression revealed relations shared with other types of cancer and others unique to HCC, namely the down-regulation of miR-122. Most importantly, functional and molecular studies uncovered mechanisms that linked deregulated miRNAs to cancer-associated pathways, thereby placing their deregulation in a more rational framework. These results improved our knowledge concerning the molecular basis of HCC and helped to increase our understanding about the great clinical potential behind these small molecules. In fact, a number of studies proved that miRNAs may have clinical relevance as bio-pathologic markers for HCC classification, prognostic stratification, early diagnosis or follow-up of patients. Additionally, the demonstration that miRNAs themselves or anti-miRNA oligonucleotides could be successfully used for in vivo modulation of miRNA actions has shown significant potentials in molecularly targeted therapy. In this context, the liver represents an organ of election to test therapeutic possibilities associated with miRNAs.
Response of calves to challenge exposure with virulent bovine respiratory syncytial virus following intranasal administration of vaccines formulated for parenteral administration (2007)

Single and combination BRSV vaccines administered intranasally provided clinical protection and sparing of pulmonary tissue similar to that detected in response to parenteral delivery of combination MLV and inactivated BRSV vaccines previously assessed in the same challenge model.
Investigation of the role of GBF1 in the replication of positive-sense single-stranded RNA viruses (2018)

GBF1 has emerged as a host factor required for the replication of positive-sense single-stranded RNA viruses of different families, but its mechanism of action is still unknown. GBF1 is a guanine nucleotide exchange factor for Arf family members. Recently, we identified Arf4 and Arf5 (class II Arfs) as host factors required for the replication of hepatitis C virus (HCV), a GBF1-dependent virus. To assess whether a GBF1/class II Arf pathway is conserved among positive-sense single-stranded RNA viruses, we investigated yellow fever virus (YFV), Sindbis virus (SINV), coxsackievirus B4 (CVB4) and human coronavirus 229E (HCoV-229E). We found that GBF1 is involved in the replication of these viruses. However, using siRNA or CRISPR-Cas9 technologies, it was seen that the depletion of Arf1, Arf3, Arf4 or Arf5 had no impact on viral replication. In contrast, the depletion of Arf pairs suggested that class II Arfs could be involved in HCoV-229E, YFV and SINV infection, as for HCV, but not in CVB4 infection. In addition, another Arf pair, Arf1 and Arf4, appears to be essential for YFV and SINV infection, but not for infection by other viruses. Finally, CVB4 infection was not inhibited by any combination of Arf depletion. We conclude that the mechanism of action of GBF1 in viral replication appears not to be conserved, and that a subset of positive-sense single-stranded RNA viruses from different families might require class II Arfs for their replication.
Induction of nuclear factor‐κB responses by the S100A9 protein is Toll‐like receptor‐4‐dependent (2012)

Summary Interactions between danger‐associated molecular patterns ( DAMP ) and pathogen‐associated molecular patterns ( PAMP ) and pattern recognition receptors such as T oll‐like receptors ( TLR s) are critical for the regulation of the inflammatory process via activation of nuclear factor‐κ B ( NF ‐κ B ) and cytokine secretion. In this report, we investigated the capacity of lipopolysaccharide ( LPS ) ‐free S 100 A 9 ( DAMP ) protein to activate human and mouse cells compared with lipoprotein‐free LPS ( PAMP ). First, we showed that LPS and S 100 A 9 were able to increase NF ‐κ B activity followed by increased cytokine and nitric oxide ( NO ) secretion both in human THP ‐1 cells and in mouse bone marrow‐derived dendritic cells. Surprisingly, although S 100 A 9 triggered a weaker cytokine response than LPS , we found that S 100 A 9 more potently induced IκBα degradation and hence NF ‐κ B activation. Both the S 100 A 9‐induced response and the LPS ‐induced response were completely absent in TLR 4 knockout mice, whereas it was only slightly affected in RAGE knockout mice. Also, we showed that LPS and S 100 A 9 NF ‐κ B induction were strongly reduced in the presence of specific inhibitors of TLR ‐signalling. Chloroquine reduced S 100 A 9 but not LPS signalling, indicating that S 100 A 9 may need to be internalized to be fully active as a TLR 4 inducer. This was confirmed using A 488‐labelled S 100 A 9 that was internalized in THP ‐1 cells, showing a raise in fluorescence after 30 min at 37°. Chloroquine treatment significantly reduced the fluorescence. In summary, our data indicate that both human and mouse S 100 A 9 are TLR 4 agonists. Importantly, S 100 A 9 induced stronger NF ‐κ B activation albeit weaker cytokine secretion than LPS , suggesting that S 100 A 9 and LPS activated NF ‐κ B in a qualitatively distinct manner.
The Effect of Applied Compressive Loading on Tissue-Engineered Cartilage Constructs Cultured with TGF-ß3 (2006)

In this study, we report that the sequential application of physiologic deformational loading after culturing with the growth factor TGF-beta3 (for 2-3 weeks) yields significantly stiffer chondrocyte-seeded agarose constructs than cultures in which deformational loading was applied during the initial 2-3 week TGF-beta3 exposure period. Using this culture protocol, engineered constructs were found to reach Young's modulus and GAG levels similar to that of native (parent) articular cartilage after only 42 days of culture. The present study extends the work on the mechanical preconditioning of engineered cartilage constructs to include transient supplementation with TGF-beta3 in a clinically-relevant, chemically-defined, serum-free media formulation.
Synthesis and characterization of Solanum nigrum-mediated silver nanoparticles and its protective effect on alloxan-induced diabetic rats (2015)

Solanum nigrum, a medicinal plant, traditionally used in treating diabetes mellitus. In this study, we used the leaf extract of the plant to synthesize silver nanoparticles (AgNPs), as a proposition to treat alloxan-induced diabetic rats. The phytosynthesised AgNPs were analyzed using UV–visible and Fourier transform infra-red spectroscopy for their functional groups. Transmission electron microscopy revealed that, the synthesized particles are found to be 4–25 nm in size. Monodispersed and spherical nature of synthesized AgNPs were shown by scanning electron microscope and the presence of Ag in the AgNPs was confirmed by energy dispersive spectrum. The phytosynthesised AgNPs were evaluated for its antidiabetic activity in alloxan-induced diabetic rats. AgNPs-treated diabetic rats found to be significantly improved the dyslipidemic condition as seen in the diabetic control. Furthermore, it also reduced the blood glucose level over the period of treatment. The improvement in body weight was also found to be evidence for S. nigrum extract-mediated AgNPs as a potential antidiabetic agent against alloxan-induced diabetic rats.
Using Self-Assembled Monolayers to Pattern ECM Proteins and Cells on Substrates (2009)

We present a method that uses microcontact printing of alkanethiols on gold to generate patterned substrates presenting "islands" of extracellular matrix (ECM) surrounded by nonadhesive regions such that single cells attach and spread only on the adhesive regions. We have used this micropatterning technology to demonstrate that mammalian cells can be switched between growth and apoptosis programs in the presence of saturating concentrations of growth factors by either promoting or preventing cell spreading (Science 276:1425-1428, 1997). From the perspective of fundamental cell biology, these results suggested that the local differentials in growth and viability that are critical for the formation of complex tissue patterns may be generated by local changes in cell-ECM interactions. In the context of cell culture technologies, such as bioreactors and cellular engineering applications, the regulation of cell function by cell shape indicates that the adhesive microenvironment around cells can be carefully optimized by patterning a substrate in addition to using soluble factors (Biotech. Prog. 14:356-363, 1998). Micropatterning technology is playing a central role both in our understanding how ECM and cell shape regulate cell physiology and in facilitating the development of cellular biosensor and tissue engineering applications (Science 264:696-698, 1994; J. Neurosci. Res. 13:213-20, 1985; Biotech. Bioeng. 43:792-800, 1994).
Synthesis of Novel Substituted Poly(arylene−vinylene)s by the Palladium-Catalyzed Three-Component Coupling Polymerization (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorSynthesis of Novel Substituted Poly(arylene−vinylene)s by the Palladium-Catalyzed Three-Component Coupling PolymerizationNobuyuki Miyaki, Ikuyoshi Tomita, Junji Kido, and Takeshi EndoView Author Information Research Laboratory of Resources Utilization, Tokyo Institute of Technology, Nagatsuta-cho 4259, Midori-ku, Yokohama 226, Japan Cite this: Macromolecules 1997, 30, 15, 4504–4506Publication Date (Web):July 28, 1997Publication History Received21 February 1997Revised13 May 1997Published online28 July 1997Published inissue 1 July 1997https://pubs.acs.org/doi/10.1021/ma9702410https://doi.org/10.1021/ma9702410rapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views360Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Conjugated polymers,Ethyl groups,Monomers,Polymerization,Polymers Get e-Alerts
An investigation of the precision impact on the Hopfield-Tank neural network model for the TSP (2002)

An advantage of the use of neural networks is the utilization of a number of processing units to obtain the solution in short time. In the design of a neural network, different bit precisions alter the computer architecture and organization on design. The authors study the impact of the precision by using the Hopfield-Tank neural network model for the traveling salesman problem (TSP). In order to simulate the TSP problem using the Hopfield-Tank model, the authors have used a number of previous studies to determine some of the required parameters. To investigate the influence of the precision, the authors have simulated the TSP problem in a MIPS R3000. The authors have considered: five different bit precisions (8- 16- 24- 32- and double precision mantissas), three values of the sigmoid generation parameters, and convergency within 1000 neuron update cycles. The authors have run a total of 7,080 simulations for the established benchmark in the MIPS-3000 machines; the simulation results are extensively discussed. Additionally, two novel approaches to measure the performance of the network, namely the average network performance and computational efficiency, are introduced and used in the evaluation of the performance of the model. Further information extraction is done by using Dempster's rule of combination for the average network performance and computational efficiency.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Computationally efficient mutual information estimation for non-rigid image registration (2008)

The accuracy and computational complexity of mutual information (MI) estimation are critical factors in multi-modality non-rigid image registration. This paper discusses the accuracy and complexity of MI estimation approaches based on non-rigid registration functions. General formulations have been derived for Shannon's and Renyi's definitions of MI, as well as Cauchy- Schwartz quadratic MI. The results obtained indicate that a fuzzy histogram binning estimation approach is significantly faster and more accurate than the conventional non-parametric Parzen window estimation approach. The analytical formulations obtained for various MI definitions are continuously differentiable and are shown to be computationally efficient for high-dimensional optimization problems particularly for non-rigid image registration.
SKI: Security Key Infrastructure for a Server Audit Certification (2005)

An authentication technology such as Public Key Infrastructure (PKI) is used for a server authentication. However, it does not certificate a status of a server side security countermeasures, e.g., a configuration and operating condition of a Firewall (FW), a Virus Detection System (VDS) and an Intrusion Detection System (IDS). When a client machine com municates the server that is vulnerable to the attack, the server may affect the critical damage to the client machine. In this paper, we propose a Security Key Infrastructure (SKI) scheme that verifies the server side security countermeasures by linkage between an external and an internal audit. We consider requirements for designs of the SKI scheme, and implement communication modules between the server and the client machine. It is shown that the proposed SKI can achieve a quick response of the server and provide the certification of the security countermeasures to the client machine.
Design and performance of an electrospray ionization time-of-flight mass spectrometer (2000)

In order to circumvent the limitations of a quadrupole mass filter, which so far has been the most common mass analyzer for use with electrospray ionization, a mass spectrometer coupling electrospray with time-of-flight mass analysis has been constructed. The design of this spectrometer, including a simple electrospray ion source, an atmosphere–vacuum interface without a rf-only quadrupole/multipole that discriminates against low mass ions which can be used for internal calibration, orthogonal extraction, and a reflectron, is presented together with its performance characteristics. A resolving power of 7500 was obtained for the +5 ion of bovine insulin and the detection limit for the same molecule was shown to be 1 f mol. Mass accuracy using a conventional two-point calibration is 60 ppm for internal calibration on low mass ions and better than 100 ppm for external calibration on peptide ions. An improved mass accuracy equal to 10 ppm was achieved using internal three-point calibration on low mass ions naturally present in the spectra. The dynamic range of a single sample was found to be at least 400:1.