gebhart/patrepeval huggingface dataset:
LRTA: A Transparent Neural-Symbolic Reasoning Framework with Modular Supervision for Visual Question Answering (2020)

The predominant approach to visual question answering (VQA) relies on encoding the image and question with a "black-box" neural encoder and decoding a single token as the answer like "yes" or "no". Despite this approach's strong quantitative results, it struggles to come up with intuitive, human-readable forms of justification for the prediction process. To address this insufficiency, we reformulate VQA as a full answer generation task, which requires the model to justify its predictions in natural language. We propose LRTA [Look, Read, Think, Answer], a transparent neural-symbolic reasoning framework for visual question answering that solves the problem step-by-step like humans and provides human-readable form of justification at each step. Specifically, LRTA learns to first convert an image into a scene graph and parse a question into multiple reasoning instructions. It then executes the reasoning instructions one at a time by traversing the scene graph using a recurrent neural-symbolic execution module. Finally, it generates a full answer to the given question with natural language justifications. Our experiments on GQA dataset show that LRTA outperforms the state-of-the-art model by a large margin (43.1% v.s. 28.0%) on the full answer generation task. We also create a perturbed GQA test set by removing linguistic cues (attributes and relations) in the questions for analyzing whether a model is having a smart guess with superficial data correlations. We show that LRTA makes a step towards truly understanding the question while the state-of-the-art model tends to learn superficial correlations from the training data.
Spectral flattening of supercontinua with a spatial light modulator (2013)

We demonstrate the generation of broad spectra with a flat intensity distribution from originally highly structured supercontinua, obtained with femtosecond pulses in a photonic crystal fiber. This is accomplished by truncating the spectra at a constant level using a liquid crystal based spatial light modulator. The technique is useful for astronomical spectrograph calibration using frequency combs, where it allows to equalize the optical power of the calibration lines. This enables an improved calibration accuracy by maximizing each line’s signal-to-noise ratio.
90 mJ parametric chirped pulse amplification of 10 fs pulses (2006)

We demonstrate the amplification of broadband pulses from a Ti:Sapphire oscillator by non-collinear optical parametric chirped-pulse amplification technique in a type-I BBO crystal to energies of 90 mJ. Partial compression of the amplified pulses is demonstrated down to a 10 fs duration. These parameters come in combination with good spatial quality and focusability of the amplified beam.
RADIOGRAPHIC COMPARISON OF TWO DIFFERENT GLENOID PREPARATION TECHNIQUES IN TOTAL SHOULDER ARTHROPLASTY (2018)

INTRODUCTION: Assessment of radiolucent lines (RLL) is the main component of the radiographic analysis of the glenoid component. The purpose of this study is to compare the radiographic results of two glenoid preparation techniques by analyzing periglenoid radiolucencies. MATERIEL AND METHODS: The series consists of seventy-two shoulder arthroplasties with primary osteoarthritis. Shoulders were divided into two groups based on glenoid preparation technique: Group 1: Thirty-seven shoulders operated on between 1991 and 1995 with flat back, polyethylene glenoid implants cemented after “curettage” of the keel slot. Group 2: Thirty-five shoulders operated on between 1997 and 1999 with flat back, polyethylene glenoid implants cemented after cancellous bone compaction of the keel slot. At least three of the following four fluoroscopically positioned, postoperative AP radiographs were analyzed: immediate postoperative, between the 3rd and 6th postoperative months, at one year postoperative and at two years postoperative. The immediate and the two year radiograph were required for study inclusion. The radiolucent line score (RLLS) was calculated using the technique of Mole, involving the summation of radiolucencies in each of six specified zones. The RLLS was compared between the two groups. RESULTS: On the immediate postoperative radiographs the average of the total RLL score of the 9 analyzes was 2.39 in Group 1 and 1.67 in Group 2 (p=0.042). There was a statistically significant association between the glenoid preparation technique and the incidence of radiolucency around the keel as well (p=0.001). There was no significant difference in radiolucency behind the faceplate between the two groups (Group 1: 1.54 and Group 2: 1.41; p=0.394). On the 2-year postoperative radiographs the average RLL score of the 9 analyzes were 6.44 in the Group1 (4.05 under the tray, and 2.39 around the keel), and 4.19 in Group2 (p=0.0005) (2.86 under the tray, and 1.33 around the keel). The radiolucency around the keel and behind the faceplate (p=0.0005) was significantly more important (p=0.001) in the “curettage” glenoid preparation population. A significantly higher degree of progression of the total RLL score (p=0.002) and of the radiolucency behind the faceplate (p=0.001) was observed in the “curettage” glenoid preparation group. DISCUSSION/CONCLUSION: Preparation of the glenoid component keel slot with cancellous bone compaction is radiographically superior to the “curettage” technique with regard to periglenoid radiolucen-cies. Although new techniques of glenoid preparation may help to decrease the rate of RLL, this study shows that even with better technique, the RLL are evolutive and may appear after few years in initially perfectly implanted glenoid.
Glycosaminoglycans and Oxalocalcic Urolithiasis (1994)

A very simple analytical procedure with dimethylmethylene blue as photometric reagent was applied for the evaluation of glycosaminoglycan (GAG) urinary excretions and concentrations in both sexes, calcium oxalate stone formers, and a control group. The GAG concentrations varied significantly in stone formers (males and females) and in the control group; moreover, in some individual cases, a deficit of urinary GAGs was clearly detected. Apart from important inhibitory effects of GAGs on heterogenous calcium oxalate nucleation, the low urinary GAG content could be the cause of a pathological epithelium, favoring stone formation. The dimethylmethylene blue method is recommended as a quick screening procedure to determine a GAG deficit.
Mechanism of Expandable Graphite Fire Retardant Action in Polyurethanes (2001)

This study deals with the effects of expandable graphite (EG) on the mechanism of degradation of polyurethane (PU). We have shown that the mechanism of expansion of the graphite is due to oxidation of the carbon layer by H2SO4, rather than its decomposition, as previously suggested in the literature. On the other hand, we have shown that the mechanism of degradation of PU is little affected by the presence of EG. However, H2SO4 induces additional reactions which do not modify the final structure of the residue. Finally, the expansion of the PU/EG formulation generates, on the surface, an insulative layer which protects the underlying material, resulting in the fire retardant properties of interest.
Human tRNA synthetase catalytic nulls with diverse functions (2014)

Genetic efficiency in higher organisms depends on mechanisms to create multiple functions from single genes. To investigate this question for an enzyme family, we chose aminoacyl tRNA synthetases (AARSs). They are exceptional in their progressive and accretive proliferation of noncatalytic domains as the Tree of Life is ascended. Here we report discovery of a large number of natural catalytic nulls (CNs) for each human AARS. Splicing events retain noncatalytic domains while ablating the catalytic domain to create CNs with diverse functions. Each synthetase is converted into several new signaling proteins with biological activities "orthogonal" to that of the catalytic parent. We suggest that splice variants with nonenzymatic functions may be more general, as evidenced by recent findings of other catalytically inactive splice-variant enzymes.
Heterogeneous Streaming (2016)

This paper introduces a new heterogeneous streaming library called hetero Streams (hStreams). We show how a simple FIFO streaming model can be applied to heterogeneous systems that include manycore coprocessors and multicore CPUs. This model supports concurrency across nodes, among tasks within a node, and between data transfers and computation. We give examples for different approaches, show how the implementation can be layered, analyze overheads among layers, and apply those models to parallelize applications using simple, intuitive interfaces. We compare the features and versatility of hStreams, OpenMP, CUDA Streams and OmpSs. We show how the use of hStreams makes it easier for scientists to identify tasks and easily expose concurrency among them, and how it enables tuning experts and runtime systems to tailor execution for different heterogeneous targets. Practical application examples are taken from the field of numerical linear algebra, commercial structural simulation software, and a seismic processing application.
Numerical modeling of nanotube embedded chemicapacitive sensors (2007)

We present a novel biochemical sensing concept and construct a computational model of its electrostatic properties. The device is a chemicapacitive sensor with an embedded nanotube replacing one of the metal plates. A schematic geometry of the proposed sensor is compared to that of a traditional chemicapacitive sensor (Patel et al., 2003). The device's capacitance changes when target particles enter the sensor. The sensor's sensitivity corresponds to the percent difference in capacitance per unit length as the sensor is contaminated. Notably, the nanotube is orders of magnitude smaller than the sensing plate in the traditional device, and is similar in size to the particles being detected. By introducing a computationally efficient, physically-based simulation, this paper demonstrates the intuitive result that the proposed sensor is far more sensitive than a traditional one.
Activity of enzymes of energy metabolism in single human preimplantation embryos (1993)

A method was developed to measure the activities of enzymes in extracts from single human preimplantation embryos. The method permits the analysis of two enzymes plus appropriate controls in an extract from a single embryo, and was used to investigate the control of energy metabolism during the development of human embryos from the two-cell to the blastocyst stage. Hexokinase (HK), 6-phosphofructokinase (PFK), pyruvate kinase (PK), fructose-1,6-diphosphate aldolase (ALD), glucose phosphate isomerase (GPI), lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G6PDH) and 2-oxoglutarate dehydrogenase (ODH) were all detectable, whereas glycogen phosphorylase (GP) was not. The enzyme activities of ODH, PFK, LDH, PK, GPI and G6PDH, averaged over all stages of development from the two-cell to blastocyst stage (days 2-6 after insemination), were 3.5, 6.6, 15, 69, 73 and 87 times greater than HK, respectively. The activity of ALD was very similar to that of HK. The activities of ALD, GPI, PFK, PK and LDH showed no significant variation with stage of development, although the activity of GPI fell significantly from the four-eight cell to the eight-sixteen cell stage (P < 0.05). HK activity decreased from the two-eight cell to the eight-sixteen cell (P < 0.05), and increased significantly from the eight-sixteen cell to the blastocyst stage (P < 0.01). The overall relationship between hexokinase activity and stage approached significance (P = 0.059, one-way analysis of variance). The activity of G6PDH decreased significantly with development (P < 0.001, one way analysis of variance).(ABSTRACT TRUNCATED AT 250 WORDS)
Regenerating new heart with stem cells (2013)

This article discusses current understanding of myocardial biology, emphasizing the regeneration potential of the adult human heart and the mechanisms involved. In the last decade, a novel conceptual view has emerged. The heart is no longer considered a postmitotic organ, but is viewed as a self-renewing organ characterized by a resident stem cell compartment responsible for tissue homeostasis and cardiac repair following injury. Additionally, HSCs possess the ability to transdifferentiate and acquire the cardiomyocyte, vascular endothelial, and smooth muscle cell lineages. Both cardiac and hematopoietic stem cells may be used therapeutically in an attempt to reverse the devastating consequences of chronic heart failure of ischemic and nonischemic origin.
Tunable Quantum Emission from Atomic Defects in Hexagonal Boron Nitride (2017)

We demonstrate that strain control of exfoliated hexagonal boron nitride allows spectral tuning of single photon emitters over 6 meV. We propose a material processing that sharply improves the single-photon purity with g(2)(0) = 0.077, and brightness with emission rate exceeding 107 counts/sec at saturation.
Suggestions for an Inquiry into the Resources of the Empire: Discussion (1906)

George Taubman Goldie, George Watt, Scott Elliot, Major Close, Major Hills, Mr. FitzGerald, John W. Evans, George Goldie, Wyndham Dunstan, Suggestions for an Inquiry into the Resources of the Empire: Discussion, The Geographical Journal, Vol. 27, No. 6 (Jun., 1906), pp. 558-566
An Advanced Orbiting Systems Approach to Quality of Service in Space-Based Intelligent Communication Networks (2006)

As humans and robotic technologies are deployed in future constellation systems, differing traffic services will arise, e.g., realtime and non-realtime. In order to provide a quality of service framework that would allow humans and robotic technologies to interoperate over a wide and dynamic range of interactions, a method of classifying data as realtime or non-realtime is needed. In this paper, we present an approach that leverages the Consultative Committee for Space Data Systems (CCSDS) Advanced Orbiting Systems (AOS) data link protocol. Specifically, we redefine the AOS Transfer Frame Replay Flag in order to provide an automated store-and-forward approach on a per service basis for use in the next-generation interplanetary Internet. In addition to addressing the problem of intermittent connectivity and associated services, we propose a follow-on methodology for prioritizing data through further modification of the AOS transfer frame.
Lastarria volcano experiment (2017)

The network consistes in 6 stations surronding the fumarole field at Lastarria volcano. These stations were operative during one month with the final purpose of detect changes in the hydrothermal system triggered by passing of seismic waves produced by artificial explosions. Waveform data are available from the GEOFON data centre, under network code 2G.
Heat sinks with fluted and wavy fins in natural and low-velocity forced convection (2002)

Novel heat sinks with fluted and wavy fin configurations are designed and fabricated together with conventional longitudinal-plate and pin fin heat sinks. The experimental apparatus, consisting of the guard heater assembly, isolation chamber, wind tunnel and data acquisition instrumentation, is described. The thermal performance of the novel and conventional heat sinks is measured and compared for the horizontal and vertical base plate orientations under natural and low-velocity forced convection conditions. Results, presented as the Nusselt number against the Rayleigh or Reynolds numbers, reveal that the pin fin heat sink outperforms the other heat sinks. The novel heat sink designs do not yield significantly better thermal performance than the conventional heat sinks.
X-ray and Electron Microscopic Analyses of Catalysts (1989)

X-ray and electron microscopic analyses are widely used techniques for characterizing catalysts. The papers thatfollow this introductory chapter will describe the application and utility of these techniques in understanding and developing new and improved catalysts.
Demonstration of efficient trichloroethylene biodegradation in a hollow-fiber membrane bioreactor (1999)

Rapid cometabolism of trichloroethylene (TCE) by pure cultures of Methylosinus trichosporium OB3b PP358 was demonstrated in a two-stage hollow-fiber membrane bioreactor over the course of 3 weeks. PP358 was grown in a continuous-flow chemostat and circulated through the shell of a hollow-fiber membrane module (HFMM), while TCE contaminated water (160 to 1450 micrograms/L) was pumped through the fiber lumen (fiber interior). In parallel-flow HFMM biological experiments, 82% to 89% of the influent TCE was removed from the lumen (5.1-min residence time) with 99% of the transferred TCE undergoing biodegradation. Biological experiments in a larger capacity baffled radial-flow HFMM resulted in 66% to 99% TCE transferred and 93% to 96% TCE biodegradation at lumen residence times of between 1.5 and 3.7 min. Biodegradation was maintained throughout the experiments at pseudo-first-order biodegradation rate constants of 0.41 to 2.8 L/mg TSS/day. Best-fit computer modeling of the baffled radial-flow biological process estimated mass transfer coefficients as large as 2.7 x 10(-2) cm/min. The computer model was also shown to simulate the experimental results quite well.
Fluorine diffusion: models and experiments (2003)

Fluorine has long been implanted as a co-dopant during the implant of boron into silicon in the form of BF/sub 2/, More recently its importance has increased because of its recognized ability to decrease the diffusion of the implanted boron resulting in shallower junctions, a requirement for continued transistor minimization. New experiments examining the time-dependence of fluorine diffusion in silicon have been performed, resulting in the discovery of a new fluorine diffusion behavior not described in previous research at these dose levels. We propose a physical-based model for this behavior based on these experiments that explains the anomalous motion of fluorine.
Recombinant anti‐podoplanin (NZ‐1) immunotoxin for the treatment of malignant brain tumors (2012)

Our study demonstrates the glioma tumor antigen podoplanin to be present at very high levels (>90%) in both glioblastoma (D2159MG, D08-0308MG and D08-0493MG) and medulloblastoma (D283MED, D425MED and DAOY) xenografts and cell line. We constructed a novel recombinant single-chain antibody variable region fragment (scFv), NZ-1, specific for podoplanin from the NZ-1 hybridoma. NZ-1-scFv was then fused to Pseudomonas exotoxin A, carrying a C-terminal KDEL peptide (NZ-1-PE38KDEL). The immunotoxin (IT) was further stabilized by a disulfide (ds) bond between the heavy-chain and light-chain variable regions as the construct NZ-1-(scdsFv)-PE38KDEL. NZ-1-(scdsFv)-PE38KDEL exhibited significant reactivity to glioblastoma and medulloblastoma cells. The affinity of NZ-1-(scdsFv), NZ-1-(scdsFv)-PE38KDEL and NZ-1 antibody for podoplanin peptide was 2.1 × 10(-8) M, 8.0 × 10(-8) M and 3.9 × 10(-10) M, respectively. In a protein stability assay, NZ-1-(scdsFv)-PE38KDEL retained 33-98% of its activity, whereas that of NZ-1-PE38KDEL declined to 13% of its initial levels after incubation at 37°C for 3 days. In vitro cytotoxicity of the NZ-1-(scdsFv)-PE38KDEL was measured in cells isolated from glioblastoma xenografts, D2159MG, D08-0308MG and D08-0493MG, and in the medulloblastoma D283MED, D425MED and DOAY xenografts and cell line. The NZ-1-(scdsFv)-PE38KDEL IT was highly cytotoxic, with an 50% inhibitory concentration in the range of 1.6-29 ng/ml. Significantly, NZ-1-(scdsFv)-PE38KDEL demonstrated tumor growth delay, averaging 24 days (p < 0.001) and 21 days (p < 0.001) in D2159MG and D283MED in vivo tumor models, respectively. Crucially, in the D425MED intracranial tumor model, NZ-1-(scdsFv)-PE38KDEL caused a 41% increase in survival (p ≤ 0.001). In preclinical studies, NZ-1-(scdsFv)-PE38KDEL exhibited significant potential as a targeting agent for malignant brain tumors.
<title>Estimation of the confidence limits of oligonucleotide-array-based measurements of differential expression</title> (2001)

Microarrays can be used to simultaneously measure the differential expression states of many mRNA's in two samples. Such measurements are limited by systematic and random errors. Systematic errors include labeling bias, imperfect feature morphologies, mismatched sample concentrations, and cross-hybridization. Random errors arise from chemical and scanning noise, particularly for low signals. We have used a combination of fluor-exchanged two- color labeling and improved normalization methods to minimize systematic errors from labeling bias, imperfect features, and mismatched sample concentrations. On-array specificity control proves and experimentally proven probe design algorithms were used to correct for cross- hybridization. Random errors were reduced via automated non-uniform feature flagging and an advanced scanner design. We have scored feature significance, using established statistical tests. We have then estimated the intrinsic random measurement error as a function of average probe signal via sample self-comparison experiments (human K-562 cell mRNA). Finally, we have combined all of these tools in the analysis of differential expression measurements between K-562 cells and HeLa cells. The results establish the importance of the elimination of systematic errors and the objective assessment of the effects of random errors in producing reliable estimates of differential expression.
Effect of liposomes on P-glycoprotein function in multidrug resistant cells (1992)

Presentation of doxorubicin in liposomes has shown to enhance the sensitivity of multidrug resistant CH LZ cells to the drug (Thierry et al. Cancer Commun. 1:311-316, 1989). We confirmed that liposomally encapsulated doxorubicin may partially overcome multidrug resistance in the human ovarian carcinoma SKVLB cell line and that this effect is, at least in part, due to an increase of cellular drug accumulation. When used at high concentration, empty liposomes appear to be specifically cytotoxic in the MDR SKVLB and CH LZ cells. As observed with certain multidrug resistance modulators, empty liposomes inhibited the specific [3H]-vincristine binding to P-glycoprotein-enriched membranes isolated from CH LZ cells (60% at 0.2 mg lipid/ml). Our data suggest that liposomes may alter the P-glycoprotein function by direct interaction.
Four-mask process based on spacer technology for scaled-down lateral NEM electrostatic actuators (2010)

This paper presents a four-mask fabrication process of lateral nanoelectromechanical (NEM) electrostatic actuators based on spacer technology. Critical dimensions of the actuators, i.e., the beam width and the gap size between the movable and fixed electrodes can be made smaller than the lithographic resolution by creating nitride spacers on an oxide hardmask followed by selective etching of the oxide hardmask. The combined oxide hardmask, nitride spacer, and another mask (photoresist mask) is then transferred to an underlying polysilicon structural layer to create lateral NEM electrostatic actuators with narrow beam and narrow gap.
Foot Flare and Foot Axis (1999)

Most commercial footwear is designed and manufactured on a curved last, although the amount of curvature of the last and the turning point of the last centerline have not been formally determined. In this study, we used principal component analysis to determine the foot axis so that lasts that match feet can be produced, resulting in a good fit. In evaluating 50 Hong Kong Chinese participants, we found that the center of the foot is located at approximately 52% of the foot length measuring from the back of the foot (SD = 0.65%) and that Hong Kong participants have a mean inflare (inward curvature) of 3.2 degrees. The foot center and inflare measures will help determine the fit between footwear and feet. Applications of this research include the ability to incorporate foot flare into the design and manufacture of footwear.