gebhart/patrepeval huggingface dataset:
The Tumor Suppressor PTEN Regulates T Cell Survival and Antigen Receptor Signaling by Acting as a Phosphatidylinositol 3-Phosphatase (2000)

The tumor suppressor gene PTEN encodes a 55-kDa enzyme that hydrolyzes both protein phosphotyrosyl and 3-phosphorylated inositol phospholipids in vitro. We have found that the latter activity is physiologically relevant in intact T cells. Expression of active PTEN lead to a 50% loss of transfected cells due to increased apoptosis, which was completely prevented by coexpression of a constitutively active, membrane-bound form of protein kinase B. A mutant of PTEN selectively lacking lipid phosphatase activity, but retaining protein phosphatase activity, had no effects on cell number. Active (but not mutant) PTEN also decreased TCR-induced activation of the mitogen-activated protein kinase ERK2 (extracellular signal-related kinase 2), as seen after inhibition of phosphatidylinositol 3-kinase. Our data indicate that PTEN is a phosphatidylinositol 3-phosphatase in T cells, and we suggest that PTEN may play a role in the regulation of T cell survival and TCR signaling by directly opposing phosphatidylinositol 3-kinase.
Improved positive polaron stability of the p-type host for long lifetime in phosphorescent organic light-emitting diodes (2021)

The device lifetime of phosphorescent organic light-emitting diodes was improved by employing a hole-transport-type host derived from carbazole with phenyl blocking groups at the 3- or 6-positions.
Stochastic reactive power management in microgrids with renewables (2015)

Distribution microgrids are being challenged by reverse power flows and voltage fluctuations due to renewable generation, demand response, and electric vehicles. Advances in photovoltaic (PV) inverters offer new opportunities for reactive power management provided PV owners have the right investment incentives. In this context, reactive power compensation is considered here as an ancillary service. Accounting for the increasing time-variability of distributed generation and demand, a stochastic reactive power compensation scheme is developed. Given uncertain active power injections, an online reactive control scheme is devised. This scheme is distribution-free and relies solely on power injection data. Reactive injections are updated using the Lagrange multipliers of a second-order cone program. Numerical tests on an industrial 47-bus microgrid and the residential IEEE 123-bus feeder corroborate the reactive power management efficiency of the novel stochastic scheme over its deterministic alternative, as well as its capability to track variations in solar generation and household demand.
Clinical experience with Tc-99m labeled (N2S2) anti-melanoma antibody fragments and single photon emission computed tomography. (1992)

We evaluated the imaging capability of murine Tc-99m-labeled antimelanoma Fab fragments in 12 patients with clinical stage II and III melanoma. Tc-99m-NRX118.7 antimelanoma Fab fragment, 10.0 to 27.2 mCi (370-1, 006 MBq), was injected IV 30 min after irrelevant nonspecific intact antibody and 5 min after intact specific antibody were given. In all patients, whole-body scans and spot views were obtained. Single photon emission computed tomography (SPECT) was additionally performed in eight of the patients. The procedure was well tolerated, and 31 of 38 known foci of melanoma were detected (sensitivity, 82%). SPECT aided in detecting and better localizing lesions in the head, neck, and chest. The specificity of the technique was satisfactory when interpretation was performed with a knowledge of normal sites of accretion and excretion of technetium-99m activity such as the kidneys and gut. In several instances, lesions were discovered by means of the antibody scan before detection by other methods, and in two instances, the lack of visualization on antibody scan of a palpable mass correctly indicated that no melanoma was present in the mass. Scan results in three patients led to alterations in patient care; including preventing aggressive surgical and nonsurgical treatments. Although these data are encouraging, evaluation in additional patients will be essential to determine the clinical utility of this antibody scan in the management of patients with melanoma.
An Avionics Diagnostics System for Regional Airlines and Business Aircraft Applied in the Beech Starship I (1988)

&lt;div class="htmlview paragraph"&gt;As avionics systems become more integrated, fault isolation becomes more costly and time consuming. The development of the Collins Concept 4 avionics architecture includes a unique central avionics diagnostics function as an integral part of the avionics structure to identify failed LRUs in the aircraft for quick flight line replacement. Most troubleshooting is eliminated. Repeat squawks are greatly reduced. The central diagnostics processor uses system-wide avionics data in a flexible, table-driven processing algorithm to pinpoint LRU failures. The first application in the Beech Starship 1 is described.&lt;/div&gt;
Hemolytic Activity of Nanoparticles as a Marker of Their Hemocompatibility (2022)

The potential use of nanomaterials in medicine offers opportunities for novel therapeutic approaches to treating complex disorders. For that reason, a new branch of science, named nanotoxicology, which aims to study the dangerous effects of nanomaterials on human health and on the environment, has recently emerged. However, the toxicity and risk associated with nanomaterials are unclear or not completely understood. The development of an adequate experimental strategy for assessing the toxicity of nanomaterials may include a rapid/express method that will reliably, quickly, and cheaply make an initial assessment. One possibility is the characterization of the hemocompatibility of nanomaterials, which includes their hemolytic activity as a marker. In this review, we consider various factors affecting the hemolytic activity of nanomaterials and draw the reader's attention to the fact that the formation of a protein corona around a nanoparticle can significantly change its interaction with the red cell. This leads us to suggest that the nanomaterial hemolytic activity in the buffer does not reflect the situation in the blood plasma. As a recommendation, we propose studying the hemocompatibility of nanomaterials under more physiologically relevant conditions, in the presence of plasma proteins in the medium and under mechanical stress.
Data from Telomerase as an Important Target of Androgen Signaling Blockade for Prostate Cancer Treatment (2023)

&lt;div&gt;Abstract&lt;p&gt;As the mainstay treatment for advanced prostate cancer, androgen deprivation therapy (ADT) targets the action of androgen receptor (AR) by reducing androgen level and/or by using anti-androgen to compete with androgens for binding to AR. Albeit effective in extending survival, ADT is associated with dose-limiting toxicity and the development of castration-resistant prostate cancer (CRPC) after prolonged use. Because CRPC is lethal and incurable, developing effective strategies to enhance the efficacy of ADT and circumvent resistance becomes an urgent task. Continuous AR signaling constitutes one major mechanism underlying the development of CRPC. The present study showed that methylseleninic acid (MSA), an agent that effectively reduces AR abundance, could enhance the cancer-killing efficacy of the anti-androgen bicalutamide in androgen-dependent and CRPC cells. We found that the combination of MSA and bicalutamide produced a robust downregulation of &lt;i&gt;prostate-specific antigen&lt;/i&gt; and a recently identified AR target, telomerase, and its catalytic subunit, &lt;i&gt;human telomerase reverse transcriptase&lt;/i&gt;. The downregulation of &lt;i&gt;hTERT&lt;/i&gt; occurs mainly at the transcriptional level, and reduced AR occupancy of the promoter contributes to downregulation. Furthermore, apoptosis induction by the two agents is significantly mitigated by the restoration of &lt;i&gt;hTERT&lt;/i&gt;. Our findings thus indicate that MSA in combination with anti-androgen could represent a viable approach to improve the therapeutic outcome of ADT. Given the critical role of &lt;i&gt;hTERT&lt;/i&gt;/telomerase downregulation in mediating the combination effect and the fact that &lt;i&gt;hTERT&lt;/i&gt;/telomerase could be measured in blood and urine, &lt;i&gt;hTERT&lt;/i&gt;/telomerase could serve as an ideal tumor-specific biomarker to monitor the efficacy of the combination therapy noninvasively. Mol Cancer Ther; 9(7); 2016–25. ©2010 AACR.&lt;/p&gt;&lt;/div&gt;
Microporous Organically Pillared Layered Silicates (MOPS): A Versatile Class of Functional Porous Materials (2018)

The design of microporous hybrid materials, tailored for diverse applications, is a key to address our modern society's imperative of sustainable technologies. Prerequisites are flexible customization of host-guest interactions by incorporating various types of functionality and by adjusting the pore structure. On that score, metal-organic frameworks (MOFs) have been the reference in the past decades. More recently, a new class of microporous hybrid materials emerged, microporous organically pillared layered silicates (MOPS). MOPS are synthesized by simple ion exchange of organic or metal complex cations in synthetic layered silicates. MOFs and MOPSs share the features of "component modularity" and "functional porosity". While both, MOFs and MOPS maintain the intrinsic characteristics of their building blocks, new distinctive properties arise from their assemblage. MOPS are unique since allowing for simultaneous and continuous tuning of micropores in the sub-Ångström range. Consequently, with MOPS the adsorbent recognition may be optimized without the need to explore different framework topologies. Similar to the third generation of MOFs (also termed soft porous crystals), MOPS are structurally ordered, permanently microporous solids that may also show a reversible structural flexibility above a distinct threshold pressure of certain adsorbents. This structural dynamism of MOPS can be utilized by meticulously adjusting the charge density of the silicate layers to the polarizability of the adsorbent leading to different gate opening mechanisms. The potential of MOPS is far from being fully explored. This Concept article highlights the main features of MOPS and illustrates promising directions for further research.
CTH13-4: Link-Adaptive Distributed Coding for Multi-Source Cooperation (2006)

Combining multi-source cooperation and link- adaptive regenerative techniques, we develop a novel protocol capable of achieving diversity up to the number of cooperating users and larger coding gains without incurring the overhead of cyclic redundancy check (CRC) codes. The resulting protocol can be further optimized to take advantage of the information provided by CRC when available. Simulations confirm our theoretical assessments.
N-(N-Benzyloxycarbonyl-L-1,2,3,4-tetrahydroisoquinol-3-ylcarbonyl)-L-phenylalanine methyl ester, Z-L-Tic-L-Phe-OMe (1994)

The title compound, C 28 H 28 N 2 O 5 , is a terminally blocked dipeptide, conformationally constrained by the presence of a 1,2,3,4-tetrahydroisoquinoline residue (Tic). The conformation of the peptide linkage is trans [ω 1 =-177.0 (3) o ] and the main chain conformation is determined by the parameters φ 1 =-86.7 (4), ψ 1 =171.5 (3), φ 2 =-77.2 (4), ψ τ =160.1 (3) o . The side chain of Tic is in a g + conformation [χ 1 1 =56.0 (4) o ], whereas the phenylalanine side chain is in a g - conformation [χ 2 1 =- 68.8 (5) o ]
A distributed coordination framework for wireless sensor and actor networks (2005)

Wireless Sensor and Actor Networks (WSANs) are composed of a large number of heterogeneous nodes called sensors and actors. The collaborative operation of sensors enables the distributed sensing of a physical phenomenon, while the role of actors is to collect and process sensor data and perform appropriate actions.In this paper, a coordination framework for WSANs is addressed. A new sensor-actor coordination model is proposed, based on an event-driven clustering paradigm in which cluster formation is triggered by an event so that clusters are created on-the-fly to optimally react to the event itself and provide the required reliability with minimum energy expenditure. The optimal solution is determined by mathematical programming and a distributed solution is also proposed. In addition, a new model for actor-actor coordination is introduced for a class of coordination problems in which the area to be acted upon is optimally split among different actors. An auction-based distributed solution of the problem is also presented.Performance evaluation shows how global network objectives, such as compliance with real-time constraints and minimum energy consumption, can be reached in the proposed framework with simple interactions between sensors and actors that are suitable for large-scale networks of energy-constrained devices.
Effect of Two-Stage Aging on Microstructure of 7075 Aluminum Alloys (1981)

WORDS (rontinue an ,overee side It n~oeessey aid identity by block number
The metabolic effects of novel peptide-based glucagon receptor antagonists in vitro and in high fat fed mice (2010)

Hyperglycaemia in type-2 diabetes is produced from a combination of impaired insulin secretion, tissue insulin resistance and enhanced secretion of glucagon, the latter resulting in increased hepatic glucose output. Thus, glucagon receptor antagonists have potential to alleviate glucagon-induced hyperglycaemia. In this study, we examined the efficacy of the novel peptide-based glucagon antagonists desHis 1 (Glu 9 )glucagon and the C-terminal mini-PEGylated form, desHis 1 (Glu 9 )glucagon[mPEG], on intracellular cAMP production and insulin secretion in vitro and glucagon-induced hyperglycaemia in vivo in insulin resistant high fat fed mice. Acute (20 min) in vitro cAMP production and insulin secretion studies were performed in glucagon receptor transfected HEK293S(GnT1) and clonal pancreatic BRIN-BD11 cells, respectively. In vivo studies were performed in National Institutes of Health Swiss mice maintained on high fat diet (45% fat) for 120 d. Groups of mice (n 8) were fasted for 4 h prior to injection (i.p.) with saline, glucagon alone and desHis 1 (Glu 9 )glucagon or desHis 1 (Glu 9 )glucagon [mPEG] with/without glucagon (all at 25 nmol/kg body weight). Blood glucose was measured at 0, 15, 30, 60 and 105 min post injection. Glucagon dose-dependently stimulated cAMP production in HEK293S(Gnt1) cells. However, desHis 1 (Glu 9 )glucagon and desHis 1 (Glu 9 )glucagon[mPEG] alone did not stimulate cAMP production. Furthermore, both peptides antagonised glucagon-induced cAMP production in vitro. In BRIN-BD11 cells, glucagon dose-dependently (10 -12 -10 -6 M) stimulated insulin secretion compared to 5.6 mM glucose control (P < 0.05 to P < 0.001). In contrast, desHis 1 (Glu 9 )glucagon and desHis 1 (Glu 9 )glucagon[mPEG] did not evoke insulin secretion above control levels. However, both peptides effectively antagonised glucagon-induced (10 -7 M) insulin secretion in vitro. In high fat fed mice, glucagon significantly (P < 0.01) elevated the overall plasma glucose excursion (0-105 min AUC) compared to saline controls. In contrast, the administration of either desHis 1 (Glu 9 )glucagon or desHis 1 (Glu 9 )glucagon [mPEG] did not induce significant changes from saline controls. Moreover, when injected concomitantly with glucagon both analogues significantly (P < 0.01 to P < 0.001) lowered individual blood glucose levels when compared to glucagon treated mice. In addition, a combined administration of glucagon and desHis 1 (Glu 9 )glucagon significantly (P < 0.05) lowered the overall glycaemic excursion (0-105 min AUC) when compared to glucagon-treated mice. In conclusion, desHis 1 (Glu 9 )glucagon is a particularly effective glucagon receptor antagonist in vitro and in vivo and may have potential in alleviation of hyperglycaemia in diabetes.
On the Challenges and Performance of Cooperative Communication in 5G and B5G Systems (2021)

URLLC is the key feature of 5G enabling extensive V2X applications and control of complex industrial processes via wireless communication systems. In order to ensure the highest reliability requirements with low latency communication, the fluctuating characteristics of a wireless link must not become a limiting factor for the use case. Cooperative communication approaches eliminate this problem by exploiting additional links via relay nodes to transmit data redundantly on different paths in the network to the destination node. We present a suitable multi-path scheme for integration in 5G and B5G systems. The theoretical analysis shows nearly one order of magnitude improvement of reliability for each additional path with the proposed architecture. Furthermore, we demonstrate a significant gain in terms of reliability for the overall link even for highly disrupted relay paths. Using experimental vehicle platooning measurements in real-world traffic based on LTE and IEEE802.11p, we confirm the conceptual advantage of our multi-path approach.
Intelligent Video Surveillance (2012)

Deployment of smart CCTV requires understanding its social-psychological impact as well as the ethical and legal implications. The featured Web extra is a video interview with Computer Identity Sciences editor Karl Ricanek, who discusses the privacy implications of increasingly pervasive technology that can track and identify individuals' movements, habits, and activities.
Tie2-mediated vascular remodeling by ferritin-based protein C nanoparticles confers antitumor and anti-metastatic activities (2020)

Cancer treatment targeting the tumor vasculature by inducing antitumor immune responses and enhancing the delivery of a chemotherapeutic agent with PCNs resulted in tumor regression and may provide an effective therapeutic strategy.
All-Optical Signal Processing for UltraHigh Speed Optical Systems and Networks (2012)

With high-bandwidth and on-demand applications continuing to emerge, next-generation core optical networks will likely require significant improvements in reconfigurability and ultra-fast operations. Optical signal processing overcomes the electronic bandwidth limitations with the advantages in terms of transparency and scalability. We review recent progresses in all-optical signal processing potentially for ultrahigh speed systems and networks. Starting from a brief overview of optical signal processing in high-speed optical systems and networks, we highlight a few key network functionalities, including optical logic operations, reconfigurable add/drop multiplexing, optical regeneration, wavelength conversion, format conversion, and phase-sensitive amplification. Different techniques are investigated and discussed, employing a wide range of devices and various nonlinearities. Some of experimental results are presented in both single polarization systems and polarization-division multiplexing systems.
Modeling of operational, software and technical systems in RFBR projects (2021)

A wide range of issues of theory and practice in the development of large-scale software and hybrid software intensive systems, including operating systems, is considered. Issues of configuration management, modeling and verification of such systems, construction of ontological models of subject areas related to application and system software are touched upon. Such multilateral consideration is necessary to ensure reliability, security and elastic development during the multi-year period of operation of infrastructural and mission-critical systems. The paper is based on the materials of studies carried out within the two RFBR projects. In addition to recent results, the authors pay attention to the history of the development of research in the relevant areas in the Soviet Union.
RinQ Fingerprinting: Recurrence-informed Quantile Networks for Magnetic\n Resonance Fingerprinting (2019)

Recently, Magnetic Resonance Fingerprinting (MRF) was proposed as a\nquantitative imaging technique for the simultaneous acquisition of tissue\nparameters such as relaxation times $T_1$ and $T_2$. Although the acquisition\nis highly accelerated, the state-of-the-art reconstruction suffers from long\ncomputation times: Template matching methods are used to find the most similar\nsignal to the measured one by comparing it to pre-simulated signals of possible\nparameter combinations in a discretized dictionary. Deep learning approaches\ncan overcome this limitation, by providing the direct mapping from the measured\nsignal to the underlying parameters by one forward pass through a network. In\nthis work, we propose a Recurrent Neural Network (RNN) architecture in\ncombination with a novel quantile layer. RNNs are well suited for the\nprocessing of time-dependent signals and the quantile layer helps to overcome\nthe noisy outliers by considering the spatial neighbors of the signal. We\nevaluate our approach using in-vivo data from multiple brain slices and several\nvolunteers, running various experiments. We show that the RNN approach with\nsmall patches of complex-valued input signals in combination with a quantile\nlayer outperforms other architectures, e.g. previously proposed CNNs for the\nMRF reconstruction reducing the error in $T_1$ and $T_2$ by more than 80%.\n
Optical antenna arrays in the visible range (2007)

We report on experimental observations of highly collimated beams of radiation generated when a periodic sub-wavelength grating interacts with surface bound plasmon-polariton modes of a thin gold film. We find that the radiation process can be fully described in terms of interference of emission from a dipole antenna array and modeling the structure in this way enables the far-field radiation pattern to be predicted. The directionality, multiplicity and divergence of the beams can be completely described within this framework. Essential to the process are the surface plasmon excitations: these are the driving mechanism behind the beam formation, phase-coupling radiation from the periodic surface structure and thus imposing a spatial coherence. Detailed fitting of the experimental and modeled data indicates the presence of scattering events involving the interaction of two surface plasmon polariton modes.
Contact Resistance and Megahertz Operation of Aggressively Scaled Organic Transistors (2011)

Bottom-gate, top-contact organic thin-film transistors (TFTs) with excellent static characteristics (on/off ratio: 10(7) ; intrinsic mobility: 3 cm(2) (V s)(-1) ) and fast unipolar ring oscillators (signal delay as short as 230 ns per stage) are fabricated. The significant contribution of the transfer length to the relation between channel length, contact length, contact resistance, effective mobility, and cutoff frequency of the TFTs is theoretically and experimentally analyzed.
ChemInform Abstract: Davidiol D, First Naturally Occurring Resveratrol Pentamer Isolated from Sophora davidii. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Field desorption arrays for neutron generator ion sources (2007)

The development of portable active neutron interrogation systems for field detection applications could be facilitated by the use of a novel microfabricated atomic deuterium ion source in compact, accelerator-driven neutron generators. This ion source uses field desorption from the tips of microfabricated field emitter-type arrays to produce atomic deuterium ions. The resulting generator design would have the unique characteristic of being easily scalable to provide the neutron outputs required to meet a wide variety of field detection needs.