gebhart/patrepeval huggingface dataset:
Revealing contributions to conduction from transport within ordered and disordered regions in highly doped conjugated polymers through analysis of temperature-dependent Hall measurements (2023)

Hall effect measurements in doped polymer semiconductors are widely reported but are difficult to interpret due to screening of Hall voltages by carriers undergoing incoherent transport. Here, we propose a refined analysis for such Hall measurements, based on measuring the Hall coefficient as a function of temperature, and modeling carriers as existing in a regime of variable ``deflectability'' (i.e., how strongly they ``feel'' the magnetic part of the Lorentz force). By linearly interpolating each carrier between the extremes of no deflection and full deflection, we demonstrate that it is possible to extract the (time-averaged) concentration of deflectable charge carriers, $\ensuremath{\langle}{n}_{d}\ensuremath{\rangle}$, the average, temperature-dependent mobility of those carriers, $\ensuremath{\langle}{\ensuremath{\mu}}_{d}\ensuremath{\rangle}(T)$, as well as the ratio of conductivity that comes from such deflectable transport, $d(T)$. Our method was enabled by the construction of an improved AC Hall measurement system, as well as an improved data extraction method. We measured Hall bar devices of ion-exchange doped films of PBTTT-${\mathrm{C}}_{14}$ from 10--300 K. Our analysis provides evidence for the proportion of conductivity arising from deflectable transport, $d(T)$, increasing with doping level, ranging between 15.4% and 16.4% at room temperature. When compared to total charge-carrier-density estimates from independent methods, the values of $\ensuremath{\langle}{n}_{d}\ensuremath{\rangle}$ extracted suggest that carriers spend $\ensuremath{\sim}37%$ of their time of flight being deflectable in the most highly doped of the devices measured here. The extracted values of $d(T)$ being less than half this value thus suggest that the limiting factor for conductivity in such highly doped devices is carrier mobility, rather than concentration.
One-Dimensional Nature of Pairing and Superconductivity at the LaAlO$_3$/SrTiO$_3$ Interface (2017)

We examine superconductivity in LaAlO$_3$/SrTiO$_3$ channels in which the channel width transitions from the 1D to 2D regime. The superconducting critical current is independent of the channel width and increases approximately linearly with the number of parallel channels. Signatures of electron pairing outside of the superconducting phase are also independent of channel width. Collectively, these results indicate that electron pairing and superconductivity exist at the boundary of these channels and are absent within the interior region of the channels. The intrinsic 1D nature of superconductivity at the LaAlO$_3$/SrTiO$_3$ interface imposes strong physical constraints on possible electron pairing mechanisms.
Coherent Anti-Stokes Raman Scattering (CARS) for Biomedical Imaging (2005)

We have achieved video rate CARS imaging of live animals with vibrational contrast. We demonstrate this important biomedical application of CARS microscopy by showing real-time chemical characterization of skin tissue of a live mouse.
Accuracy of left ventricular mechanical dyssynchrony indices for mechanical characteristics of left bundle branch block using cardiovascular magnetic resonance feature tracking (2022)

Abstract Aims More than 90% of patients with left bundle branch block (LBBB) and reduced left ventricular (LV) ejection fraction have LV dyssynchrony and a high probability of response to cardiac resynchronization therapy (CRT). A subgroup of patients with non-specific intraventricular conduction delay (IVCD) have a LBBB-like LV activation pattern when studied using invasive mapping and advanced echocardiographic techniques. These patients also frequently benefit from CRT but these patients have proven difficult to identify using ECG criteria. Cardiovascular magnetic resonance (CMR) imaging indices of dyssynchrony may identify patients with IVCD who may benefit from CRT but their relative accuracies for identification of LV dyssynchrony remains unknown. We compared the LV dyssynchrony classification accuracy of two commonly available CMR indices in a study population of patients with severely reduced LV ejection fraction and no scar, and either LBBB or normal conduction (normal QRS duration and axis, controls). Methods and results In LBBB (n=44) and controls (n=36), using CMR feature tracking circumferential strain, dyssynchrony was quantified as the circumferential uniformity ratio estimate (CURE) and the systolic stretch index (SSI). Deidentified CMR image-data were made publicly available. Both CURE and SSI quantified more severe dyssynchrony in LBBB compared to controls (p&lt;0.001 for both). SSI more frequently discriminated LBBB and normal conduction LV activation patterns than CURE (area under the receiver operating characteristics curve [95% confidence interval] 0.98 [0.95-1.00] for SSI vs 0.77 [0.66-0.86] for CURE, p&lt;0.001). Conclusions SSI is superior to CURE for discriminating synchronous and dyssynchronous LV activation and should be further studied in the setting of non-LBBB conduction abnormalities.
A cGMP-applicable Expansion Method for Aggregates of Human Neural Stem and Progenitor Cells Derived From Pluripotent Stem Cells or Fetal Brain Tissue (2014)

A cell expansion technique to amass large numbers of cells from a single specimen for research experiments and clinical trials would greatly benefit the stem cell community. Many current expansion methods are laborious and costly, and those involving complete dissociation may cause several stem and progenitor cell types to undergo differentiation or early senescence. To overcome these problems, we have developed an automated mechanical passaging method referred to as "chopping" that is simple and inexpensive. This technique avoids chemical or enzymatic dissociation into single cells and instead allows for the large-scale expansion of suspended, spheroid cultures that maintain constant cell/cell contact. The chopping method has primarily been used for fetal brain-derived neural progenitor cells or neurospheres, and has recently been published for use with neural stem cells derived from embryonic and induced pluripotent stem cells. The procedure involves seeding neurospheres onto a tissue culture Petri dish and subsequently passing a sharp, sterile blade through the cells effectively automating the tedious process of manually mechanically dissociating each sphere. Suspending cells in culture provides a favorable surface area-to-volume ratio; as over 500,000 cells can be grown within a single neurosphere of less than 0.5 mm in diameter. In one T175 flask, over 50 million cells can grow in suspension cultures compared to only 15 million in adherent cultures. Importantly, the chopping procedure has been used under current good manufacturing practice (cGMP), permitting mass quantity production of clinical-grade cell products.
Methods to Locate Center of Gravity in Scoliosis (2003)

Methods have been developed to determine locations of the whole body COG in both preoperative and postoperative subjects undergoing spinal fusion surgery and controls. The methods are robust to include men and women, subjects with and without instrumentation, and subjects in various positions including gait.
Mechanisms of quinolone resistance inEscherichia coliisolated from companion animals, pet-owners, and non-pet-owners (2017)

The present study investigated the prevalence and mechanisms of fluoroquinolone (FQ)/quinolone (Q) resistance in <i>Escherichia</i> (<i>E</i>.) <i>coli</i> isolates from companion animals, pet-owners, and non-pet-owners. A total of 63 <i>E. coli</i> isolates were collected from 104 anal swab samples, and 27 nalidixic acid (NA)-resistant isolates were identified. Of those, 10 showed ciprofloxacin (CIP) resistance. A plasmid-mediated Q resistance gene was detected in one isolate. Increased efflux pump activity, as measured by organic solvent tolerance assay, was detected in 18 NA-resistant isolates (66.7%), but was not correlated with an increase in minimum inhibitory concentration (MIC). Target gene mutations in Q resistance-determining regions (QRDRs) were the main cause of (FQ)Q resistance in <i>E. coli.</i> Point mutations in QRDRs were detected in all NA-resistant isolates, and the number of mutations was strongly correlated with increased MIC (<i>R</i> = 0.878 for NA and 0.954 for CIP). All CIP-resistant isolates (n = 10) had double mutations in the <i>gyrA</i> gene, with additional mutations in <i>parC</i> and <i>parE</i>. Interestingly, (FQ)Q resistance mechanisms in isolates from companion animals were the same as those in humans. Therefore, prudent use of (FQ)Q in veterinary medicine is warranted to prevent the dissemination of (FQ)Q-resistant bacteria from animals to humans.
Upstream Regulator Analysis of Wooden Breast Myopathy Proteomics in Commercial Broilers and Comparison to Feed Efficiency Proteomics in Pedigree Male Broilers (2021)

In an effort to understand the apparent trade-off between the continual push for growth performance and the recent emergence of muscle pathologies, shotgun proteomics was conducted on breast muscle obtained at ~8 weeks from commercial broilers with wooden breast (WB) myopathy and compared with that in pedigree male (PedM) broilers exhibiting high feed efficiency (FE). Comparison of the two proteomic datasets was facilitated using the overlay function of Ingenuity Pathway Analysis (IPA) (Qiagen, CA, USA). We focused on upstream regulator analysis and disease-function analysis that provides predictions of activation or inhibition of molecules based on (a) expression of downstream target molecules, (b) the IPA scientific citation database. Angiopoeitin 2 (ANGPT2) exhibited the highest predicted activation Z-score of all molecules in the WB dataset, suggesting that the proteomic landscape of WB myopathy would promote vascularization. Overlaying the FE proteomics data on the WB ANGPT2 upstream regulator network presented no commonality of protein expression and no prediction of ANGPT2 activation. Peroxisome proliferator coactivator 1 alpha (PGC1α) was predicted to be inhibited, suggesting that mitochondrial biogenesis was suppressed in WB. PGC1α was predicted to be activated in high FE pedigree male broilers. Whereas RICTOR (rapamycin independent companion of mammalian target of rapamycin) was predicted to be inhibited in both WB and FE datasets, the predictions were based on different downstream molecules. Other transcription factors predicted to be activated in WB muscle included epidermal growth factor (EGFR), X box binding protein (XBP1), transforming growth factor beta 1 (TGFB1) and nuclear factor (erythroid-derived 2)-like 2 (NFE2L2). Inhibitions of aryl hydrocarbon receptor (AHR), AHR nuclear translocator (ARNT) and estrogen related receptor gamma (ESRRG) were also predicted in the WB muscle. These findings indicate that there are considerable differences in upstream regulators based on downstream protein expression observed in WB myopathy and in high FE PedM broilers that may provide additional insight into the etiology of WB myopathy.
Versatile buffer layer architectures based on Ge1−xSnx alloys (2005)

We describe methodologies for integration of compound semiconductors with Si via buffer layers and templates based on the GeSn system. These layers exhibit atomically flat surface morphologies, low defect densities, tunable thermal expansion coefficients, and unique ductile properties, which enable them to readily absorb differential stresses produced by mismatched overlayers. They also provide a continuous selection of lattice parameters higher than that of Ge, which allows lattice matching with technologically useful III-V compounds. Using this approach we have demonstrated growth of GaAs, GeSiSn, and pure Ge layers at low temperatures on Si(100). These materials display extremely high-quality structural, morphological, and optical properties opening the possibility of versatile integration schemes directly on silicon.
Visual Quality Assessment of 3D Models (2017)

Geometric modifications of three-dimensional (3D) digital models are commonplace for the purpose of efficient rendering or compact storage. Modifications imply visual distortions that are hard to measure numerically. They depend not only on the model itself but also on how the model is visualized. We hypothesize that the model’s light environment and the way it reflects incoming light strongly influences perceived quality. Hence, we conduct a perceptual study demonstrating that the same modifications can be masked, or conversely highlighted, by different light-matter interactions. Additionally, we propose a new metric that predicts the perceived distortion of 3D modifications for a known interaction. It operates in the space of 3D meshes with the object’s appearance, that is, the light emitted by its surface in any direction given a known incoming light. Despite its simplicity, this metric outperforms 3D mesh metrics and competes with sophisticated perceptual image-based metrics in terms of correlation to subjective measurements. Unlike image-based methods, it has the advantage of being computable prior to the costly rendering steps of image projection and rasterization of the scene for given camera parameters.
Comparative Study of Single-, Few-, and Multilayered Graphene toward Enzyme Conjugation and Electrochemical Response (2012)

Graphene, with its exceptional mechanical, thermal, electrical, optical, and electronic properties may exist as single-, few-, or multilayered thin sheets. Though the number of layers may affect conductivity, its role toward enzyme immobilization and enzymatic biosensing applications is unknown. Herein, we report the electrochemical performance of electrodes of graphene comprising varying layers immobilized with the enzyme glucose oxidase for the detection of the model analyte glucose. It is interesting to note that these different-layered graphene exhibit an identical electrochemical performance and sensitivity toward the detection of glucose. In addition, all of these electrodes exhibited a similar percentage of electrode fouling after 60 cycles. Following this, we have then calculated the amount of enzyme bound to the electrode surface. Results indicated that single-, few-, and multilayered graphene electrodes immobilize a similar amount of glucose oxidase. Thus, together, these results demonstrate that the number of layers stacked within the graphene structure have no significant role in the enzyme conjugation and subsequent electrochemical response during the electroanalysis.
Asanguineous Whole Body Perfusion with a New Intracellular Acellular Solution and Ultraprofound Hypothermia Provides Cellular Protection During 3.5 Hours of Cardiac Arrest in a Canine Model (1994)

Temporary cessation of blood flow is a necessary aid for certain complex neurosurgical and cardiovascular procedures, and hypothermia is often used to help protect against the deleterious effects of ischemia and anoxia. In an attempt to protect cellular integrity during ultraprofound hypothermia (< 10 degrees C) and complete blood substitution, two new crystalloid-colloid blood substitutes (Hypothermosol-maintenance [HTS-M] and Hypothermosol-purge [HTS-P]) have been evaluated. Using extracorporeal bypass, 14 dogs were totally exsanguinated during cooling using the HTS-P solution, then perfused (40-85 ml/kg/min; mean arterial blood pressure = 25-40 mmHg) with either TS-M (Group I, n = 11), or with HTS-P as controls (Group II, n = 3) for 3 hr at 7 degrees C. During warming, the dogs were autotransfused and observed neurologically and biochemically during recovery. All dogs in Group I recovered and eight have survived long term (12-80 weeks) without apparent neurologic deficits. In contrast, dogs in Group II were more difficult to revive (cardiac resuscitation); two survived long term with delayed neurologic recovery. Evaluation of biochemical parameters showed only a transient and inconsequential elevation in enzymes (e.g., brain, liver, and heart) in Group I compared with the markedly greater elevations in Group II. The faster neurologic recovery of dogs treated with the "intracellular" maintenance solution supports the biochemical data showing the benefits of this type of blood substitute for extending the safe limits of hypothermic cardiac arrest to beyond 3 hr.
Abstract B88: A selective Raf kinase inhibitor induces cell death and tumor regression of human cancer cell lines encoding B-RafV600E mutation (2009)

Abstract Activation of the Ras-Raf-MEK-ERK pathway has been implicated in a large range of human cancers. Growth factor receptor stimulation by extracellular ligands activates Ras, which then sets in motion a signal transduction cascade through the Raf, MEK and ERK serine/threonine kinases. Mutation of the B-Raf kinase constitutively activates MAPK signalling, thus bypassing the need for upstream stimuli. This has been genetically associated with several human cancers, especially occurrence of the B-RafV600E mutant and its high prevalence in melanoma, colorectal carcinoma, ovarian cancer, papillary thyroid carcinoma, and cholangiocarcinoma. The ability to selectively and potently inhibit B-Raf should provide a potential therapy for patients with mutant B-Raf tumors, for which addictive dependency on this pathway is observed. We have identified a novel, potent, and selective Raf kinase inhibitor that is capable of inhibiting the kinase activity of wild-type B-Raf, B-RafV600E and c-Raf with IC50 values of 3.2, 0.8, and 5.0 nM, respectively. Kinase panel screening for over 270 kinases has indicated that this inhibitor is selective for Raf kinase, with ∼400 fold selectivity towards B-Raf over 91% of the other kinases tested. Specific cellular inhibition of B-RafV600E kinase by this inhibitor leads to decreased ERK phosphorylation and inhibition of cell proliferation by an initial arrest in the G1 phase of the cell cycle, followed by cell death. This inhibition is selective for cancer cells that specifically encode the mutation for B-RafV600E. Oral compound administration inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. This cell-specific B-RafV600E inhibitor is currently being evaluated in a human Phase I clinical trial. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):B88.
Using nudges to accelerate code reviews at scale (2022)

We describe a large-scale study to reduce the amount of time code review takes. Each quarter at Meta we survey developers. Combining sentiment data from a developer experience survey and telemetry data from our diff review tool, we address, “When does a diff review feel too slow?” From the sentiment data alone, we learn that 84.7% of developers are satisfied with the time their diffs spend in review. By enriching the survey results with telemetry for each respondent, we determined that sentiment is closely associated with the 75th percentile time in review for that respondent’s diffs, ie those that take more than 24 hours.
Miscibility of Blends of Saturated Hydrocarbon Elastomers (1999)

Abstract Over the last several years, a great deal of progress has been made in understanding the basic miscibility between saturated hydrocarbon polymers. This has mainly been accomplished through the use of neutron scattering, but has also benefited by the results from light scattering, pressure-volume-temperature (PVT) measurements, and other techniques. This paper concentrates on the results that apply to elastomers such as polyisobutylene (PIB) and ethylene-propylene-diene rubber (EPDM).
ChemInform Abstract: DIELS‐ALDER APPROACH TO BICYCLIC α‐HYDROXY KETONES. FACILE KETOL REARRANGEMENTS OF STRAINED α‐HYDROXY KETONES (1985)

Abstract Die Dienophilen (I) reagieren mit Cyclopentadien unter Diels‐Alder‐Addition zu den Verbindungen (II) als Hauptprodukte sowie zu deren Isomeren (III).
Balloon Catheterization Induces Arterial Expression of Embryonic Fibronectins (1995)

Fibronectins (FNs) comprise a family of adhesive extracellular matrix proteins that arise by alternative splicing in three regions: V (IIICS), EIIIA (ED-A), and EIIIB (ED-B). FNs bearing the EIIIA and EIIIB segments are prevalent during embryogenesis, expressed to lesser degrees in normal adult tissues, and may be locally reexpressed at adult tissue injury. RNase mapping shows that normal rat arteries express low levels of FNs that are predominantly EIIIA- and EIIIB-. Following balloon injury, arterial walls produce increased total levels of FN transcripts that preferentially include both the EIIIA and EIIIB segments. However, despite inducing increased total FN mRNA, balloon injury does not alter the relative composition of V120+, V95+, AND V0 spliced forms. In situ hybridization reveals that as early as 4 days after injury medial cells express increased total FN mRNA, and by 7 days substantial neointimal and focal medial synthesis of EIIIA+, EIIIB+, and V120+ FNs occurs; macrophages do not significantly contribute to this observed vascular FN synthesis. Consistent with the mRNA data, immunofluorescence microscopic analysis reveals increased deposition of EIIIB+ and V+ FN protein forms in injured arterial walls, particularly within the neointima. Our results suggest that local synthesis of specific FN isoforms is important to the neointimal formation that ensues after balloon injury.
Thermal Stresses Relief Carrier-Based PWM Strategy for Single-Phase Multilevel Inverters (2017)

Enhancing power cycling capability of power semiconductor devices is highly demanded in order to increase the long-term reliability of multilevel inverters. Ageing of power switches and their cooling systems leads to their accelerated damage due to excess power losses and junction temperatures. Therefore, thermal stresses relief (TSR) is the most effective solution for lifetime extension of power semiconductor devices. This paper presents a new TSR carrier-based pulse width modulation (TSRPWM) strategy for extending the lifetime of semiconductor switches in single-phase multilevel inverters. The proposed strategy benefits the inherent redundancy among switching states in multilevel inverters to optimally relieve the thermally stressed device. The proposed algorithm maintains the inverter operation without increased stresses on healthy switches and without reduction of the output power ratings. In addition, the proposed algorithm preserves voltage balance of the dc-link capacitors. The proposed strategy is validated on a single-phase five-level T-type inverter system with considering different locations of thermal stresses detection. Experimental prototype of the selected case study is built to verify the results. Moreover, comparisons with the most featured strategies in literature are given in detail.
Power Alignment of Digital Predistorters for Power Amplifiers Linearity Optimization (2009)

In this paper, a study of the power alignment issue in digital predistorters is presented. The proper alignment is achieved by adjusting the normalization gain used to synthesize the predistortion function. The dependencies of the linearity and power efficiency of the linearized amplifier upon the gain normalization factor are investigated, and it is shown that the efficiency of the linearized amplifier is almost unaffected by variation of the normalization gain. Conversely, the linearity performance of the linearized power amplifier is found to be dependent on the gain normalization factor, as a consequence of the average power variation through the predistorter. Indeed, the proper power alignment of the predistorter following an adequate choice of the normalization gain shows a significant improvement in the measured adjacent channel power ratio at the linearized amplifier output.