gebhart/patrepeval huggingface dataset:
The Follicular Lymphoma International Prognostic Index (FLIPI) Can Be a Useful Prognostic Indicator for Patients with Follicular Lymphoma Treated with Combination of Rituximab and Epratuzumab. (2005)

Abstract Background: FLIPI has been proposed as an accurate, simple, and validated prognostic index on the basis of routinely performed tests (age &amp;gt; 60 yrs, Ann Arbor stage III-IV, serum LDH level increased, Hg &amp;lt; 12g/dL, and more than four nodal areas involved (Solal-Céligny et al., Blood2004; 104: 1258–1265). FLIPI has reliably predicted outcome for many follicular lymphoma (FL) patients (pts) treated with chemotherapy and rituximab. Currently, monoclonal antibody (Mab) therapy and a number of radioimmunoconjugates are considered important components of the treatment of FL; therefore, evaluating FLIPI in clinical trials of these modalities is of interest for optimizing therapy. Methods: A subset analysis was performed to assess the impact of FLIPI on the outcome of patients with relapsed/refractory FL enrolled in a larger, multi-center, open label, single-arm study of epratuzumab (humanized anti-CD22 Mab) in combination with rituximab (chimeric anti-CD20 Mab) (Strauss et al., ASCO 2004). Results: A total of 32 pts with FL were treated according to this protocol (4 weekly infusions at full dose of each agent), including 16 pts who had received &amp;gt; 2 prior chemotherapy regimens and 11 pts who had previously received rituximab. Twenty pts (62%) achieved an objective response (OR), including 8 pts (25%) with complete responses (CR, CRu) and 12 (37%) with partial responses, with a median response duration of 16.5 months (95% CI: 6.3 - 25.4) and median time-to-progression (TTP) of 11 months (95% CI: 9.9 - 19.2). Conclusion: Our data indicate that high OR rates and durable CR/CRu’s can be achieved with a combination of rituximab and epratuzumab in pts with low- (0–1) and intermediate-risk (2) FL, who failed multiple prior therapies. OR, CR rates and TTP are similar to rituximab front-line therapy for pts with low tumor burden FL (Solal-Céligny et al., Blood104: 169a, 2004). The combination of rituximab and epratuzumab was significantly less efficacious for pts with high-risk (3–5) FLIPI (P=.0.0023 for TTP). This small Phase-II study supports the prognostic value of FLIPI for pts with recurrent FL who are treated with MAbs. Prospective use of FLIPI may facilitate the optimal design of randomized trials using rituximab in combination with epratuzumab in pts with FL. Results stratified by FLIPI risk groups FLIPI score (No. of pts) OR (%) CR/CRu (%) Median Duration in months (95% CI) Median TTP in months (95% CI) TTP P-value* N/A - Not available due to patients with long TTPs that are still censored (i.e. not reached progression of disease). * - Patients with high (3–5) FLIPI scores versus others, based on the log-rank test. 0–1 (11) 9 (82) 4 (36) 15.7 (N/A) 19.2 (10.3 – 21.3) 0.0023 2 (9) 6 (67) 3 (33) 18.3 (17.2 – 25.4) 18.8 (10 – 26.7) 3–5 (12) 5 (42) 1 (8) 6.3 (N/A) 7.7 (7.1 – 10.2)
Supplementary Table S1 from An Integrated Approach Identifies Mediators of Local Recurrence in Head and Neck Squamous Carcinoma (2023)

&lt;p&gt;Supplementary Table S1: Molecular and Pathological variables of patients included in the discovery cohort.&lt;/p&gt;
An experimental investigation of resonance curves on metallic surfaces in dynamic force microscopy: the influence of frozen versus mobile charges (2004)

Amplitude resonance curves of a driven dynamic force microscope cantilever interacting with a Cu(100) substrate in ultra high vacuum are derived and analysed, extending a previous study on Al2O3(0001) (Polesel-Maris et al 2003 Nanotechnology 14 1036). It is shown that the charges that are trapped on the oxidized n+-doped silicon tip give rise to long-range electrostatic forces that dominate the van der Waals forces, due to the metallic nature of the substrate. These electrostatic forces cannot be compensated by the usual procedure consisting of applying a constant bias voltage between the tip and the sample. Indeed, the trapped charge does not remain constant on the timescale of the experiment due to charge leakage across the tip oxide layer. Removal of this oxide by electron field emission solves this problem and allows the access of a pure van der Waals tip–substrate interaction regime.
uPA contributes to impairment of hypercapnic and hypotensive cerebrovasodilation in an LRP and ERK MAPK dependent process (2006)

Cerebral hypoxia/ischemia (H/I) impairs pial artery dilation (PAD) to hypercapnia and hypotension but not isoproterenol in the newborn pig. We investigated the role of endogenous urokinase plasminogen activator (uPA), the low‐density lipoprotein related protein (LRP) receptor, and the ERK isoform of mitogen activated protein kinase (MAPK) in vasodilator impairment after H/I in piglets equipped with a closed cranial window. CSF uPA increased from 9 ± 2 to 52 ± 8 and 140 ± 21 ng/ml at 1 and 4h after H/I, respectively. The LRP antagonist receptor associated protein (RAP) and anti‐LRP antibody blunted the increase in CSF uPA at 1h (17 ± 2 ng/ml) but not 4h post insult. uPA detectable in sham‐treated piglet parietal cortex by immunocytochemistry was markedly elevated 4h after H/I. Phosphorylation (activation) of ERK MAPK was detected 1 and 4h post H/I and blocked by RAP. Exogenous uPA administered at 4h post H/I further stimulated ERK MAPK phosphorylation, blocked by RAP. Pre‐treatment with RAP, anti‐LRP, and soluble uPA receptor completely prevented and the ERK MAPK antagonist U 0126, partially prevented the impairment to hypotension and hypercapnia post‐H/I, but none of these antagonists affected the response to isoproterenol. These data indicate that uPA is released after H/I through an LRP‐initiated process and that the released uPA impairs hypercapnic and hypotensive PAD in an LRP‐ and ERK MAPK‐dependent pathway. These data suggest that modulation of uPA expression and/or action may preserve cerebrohemodynamic control after H/I.
Digital signal processing using periodically-poled lithium-niobate waveguides (2005)

Periodically-poled lithium-niobate waveguides can be used as a high-speed, low-noise optical mixer. We discuss the recent advances in device characteristics as well as a several optical-signal-processing applications, including: wavelength conversion, time (de)multiplexing, data header recognition and writing, addition, subtraction, and code conversion.
Structural Analysis of Bottlebrush Block Copolymer Micelles Using Small-Angle X-ray Scattering (2020)

We present structural analysis of spherical diblock copolymer micelles where core blocks have bottlebrush architecture. The dependence of the core radius (<i>R</i><sub>core</sub>) and the corona thickness (<i>L</i><sub>corona</sub>) on the core block length (<i>N</i><sub>core</sub>) is investigated using small-angle X-ray scattering (SAXS) and discussed in terms of the stiffness of a core-forming polymer posed by its long fluoroalkyl side chains. The conformation of the core block is strongly stretched, and the measured exponents α and β from power-law correlations, <i>R</i><sub>core</sub> ∼ <i>N</i><sub>core</sub><sup>α</sup> and <i>L</i><sub>corona</sub> ∼ <i>N</i><sub>core</sub><sup>β</sup>, respectively, are greater than those from any scaling predictions for block copolymer micelles with a flexible, linear core-block. Such deviations are attributed to the appreciable chain stiffness of the bottlebrush core block, and a simple model is suggested to understand how the core block stiffness influences both the dimensions of core and corona.
AIDS viral DNA amplification by polymerase chain reaction employing primers selected by AI expert system and an ART neural network (2002)

To diagnose AIDS patients, doctors are starting to use the methodology of amplification induced by thermal annealing and by adding specific primers to imitate the polymerase chain reaction of the denatured DNA mutated by several types of human immunodeficiency viruses. An adaptive resonance theory (ART) neural network working in concert with an artificial intelligence (AI) rule-based system is shown to be efficient for enhancing the choice of the needed good primers. Because of the tradeoff between the simplicity of primers and the specifics of primers, doctors prefer to diagnose different viral types by administering patients with different sets of good primers. Thus, AI provides ART with both the background for self-organization and the foreground for the final goal.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
SoundSaber - A Motion Capture Instrument (2011)

The paper presents the SoundSaber - a musical instrument based on motion capture technology. We present technical details of the instrument and discuss the design development process. The SoundSaber may be used as an example of how high-delity motion capture equipment can be used for prototyping musical instruments, and we illustrate this with an example of a low-cost implementation of our motion capture instrument.
Nucleus detection using gradient orientation information and linear least squares regression (2015)

Computerized histopathology image analysis enables an objective, efficient, and quantitative assessment of digitized histopathology images. Such analysis often requires an accurate and efficient detection and segmentation of histological structures such as glands, cells and nuclei. The segmentation is used to characterize tissue specimens and to determine the disease status or outcomes. The segmentation of nuclei, in particular, is challenging due to the overlapping or clumped nuclei. Here, we propose a nuclei seed detection method for the individual and overlapping nuclei that utilizes the gradient orientation or direction information. The initial nuclei segmentation is provided by a multiview boosting approach. The angle of the gradient orientation is computed and traced for the nuclear boundaries. Taking the first derivative of the angle of the gradient orientation, high concavity points (junctions) are discovered. False junctions are found and removed by adopting a greedy search scheme with the goodness-of-fit statistic in a linear least squares sense. Then, the junctions determine boundary segments. Partial boundary segments belonging to the same nucleus are identified and combined by examining the overlapping area between them. Using the final set of the boundary segments, we generate the list of seeds in tissue images. The method achieved an overall precision of 0.89 and a recall of 0.88 in comparison to the manual segmentation.
Spinal Cord Toxicity Complicating Treatment with Cisplatin and Etoposide (1990)

Neurologic toxicity occurring in patients treated with cisplatin chemotherapy is limited primarily to peripheral neuropathy and ototoxicity. Lhermitte's sign, electric-like paresthesias precipitated by cervical spine flexion, has recently been described as a self-limited complication in cisplatin-treated patients. We report the development of Lhermitte's sign accompanied by cervical motor neuropathy, dorsal column myelopathy, and sensory neuropathy in a patient treated with cisplatin and etoposide for small cell lung cancer. Persistence of the neurologic deficit suggests that potentially irreversible spinal cord toxicity may complicate treatment with this chemotherapy combination.
Capturing and sharing stories in virtual and interactive web environments (2010)

This case study describes the collaboration between Xerox Research and The Henry Ford Museum to explore ways to enable museum staff and visitors to interact with artifacts and each other in online environments. Building on the premise that stories are an integral part of the museum experience, the team developed prototype technologies, initially for use by the museum staff, to create stories around collection elements and enable story sharing and collaboration in 3D immersive environments. Ongoing feedback and evaluations by the museum staff guided prototype revisions. Suggestions by the museum staff for use of the prototypes in museum and educational contexts are also discussed.
ChemInform Abstract: BIOMIMETISCHE SYNTH. DES BIS‐INDOL‐ALKALOIDS MACRALSTONIN (1973)

Abstract Macrolin (I) und Alstophyllin (II) reagieren in 0,2 n Salzsäure bei 20°C zur gesuchten Verbindung (III).
Clutter and sources of image degradation in fundamental and harmonic ultrasound imaging. (2010)

Although harmonic imaging is used extensively, the mechanisms for image quality improvement are still poorly understood. Complex simulations or experiments that incorporate the effects of tissue heterogeneities and multiple scattering are required to describe image quality metrics such as clutter noise and less sensitivity to phase aberration. A finite difference simulation of ultrasonic propagation in a medium with heterogeneities in nonlinearity, attenuation, density, and speed of sound is presented. We investigate scattering from sub-wavelength targets and from macroscopic tissue structure. The simulated acoustic response from a single sub-wavelength scatterer is compared to analytical results for different scatterer sizes. This numerical implementation is then used to model tissue in the human body based on the visible human project and insonication from a from a 2.1-MHz diagnostic transducer. There is a close agreement between the analytical Rayleigh distribution, where the scattered intensity is proportional to f4, and simulation. The primary source of image degradation in the fundamental PSF comes from reverberation in the near-field abdominal structures. Phase aberration is the largest source of clutter in the harmonic PSF. Clutter in the PSFs occurs primarily from low-level contributions distributed over a large area.
A pH sensor based on electric properties of nanotubes on a glass substrate (2007)

Abstract We fabricated a pH-sensitive device on a glass substrate based on properties of carbon nanotubes. Nanotubes were immobilized specifically on chemically modified areas on a substrate followed by deposition of metallic source and drain electrodes on the area. Some nanotubes connected the source and drain electrodes. A top gate electrode was fabricated on an insulating layer of silane coupling agent on the nanotube. The device showed properties of an n -type field effect transistor when a potential was applied to the nanotube from the top gate electrode. Before fabrication of the insulating layer, the device showed that the p -type field effect transistor and the current through the source and drain electrodes depend on the buffer pH. The current increases with decreasing pH of the CNT solution. This device, which can detect pH, is applicable for use as a biosensor through modification of the CNT surface.
Single-cell RNA sequencing of SARS–CoV-2 cell entry factors in the preconceptional human endometrium (2021)

This study was jointly supported by the March of Dimes, Chan Zuckerberg Biohub and MINECO/FEDER (SAF-2015-67164-R, to C.S.) (Spanish Government), and the European Union's Horizon 2020 Framework Programme for Research and Innovation (Grant agreement 874867). W.W. was supported by the Stanford Bio-X Graduate Bowes Fellowship and Chan Zuckerberg Biohub. F.V. was supported by the Miguel Servet Program Type II of ISCIII (CPII18/00020) and the FIS project (PI18/00957). A patent disclosure has been filed for the study with the title 'Methods for assessing endometrial transformation' and the global patent number 'EP 3807648 A2' under the inventors S.R.Q., C.S., W.W. and F.V. C.S. is the Founder and Head of the Scientific Advisory Board of Igenomix SL. S.R.Q is the Director of Mirvie. I.M. is partially employed by Igenomix SL. B.R. has no interests to declare.
Optimized space sampling for circular image cube trajectory analysis (2005)

Image cube trajectory (ICT) analysis is a new and robust method to estimate the 3D structure of a scene from a set of 2D images. The motion of points in 3D space is represented by trajectories in an image cube. The advantage of this method is that the motion information of a single 3D point can be represented and analyzed for all available images simultaneously. ICT analysis is based on the definition of an occlusion compatible search strategy in the image cube for known parametrized camera setups. In this paper we derive rules for an optimized sampling of the considered 3D space. They can also be applied to many other 3D reconstruction approaches such as voxel coloring (S. M. Seitz and C. R. Dyer, 1997). We restricted our discussion to a circular moving camera.
Towards Semantics-Based Instantiation of Services (2011)

Nowadays web users have clearly expressed their wishes to receive and interact with personalized services directly. However, existing approaches, largely syntactic content-based, fail to provide robust, accurate and useful personalized services to its users. Towards such an issue, the semantic web provides technologies to annotate and match services' descriptions with users' features, interests and preferences, thus allowing for more efficient access to services and more generally information. The aim of our work, part of service personalization, is on automated instantiation of services which is crucial for advanced usability i.e., how to prepare and present services ready to be executed while limiting useless interactions with users? To this end, we exploit Description Logics reasoning through semantic matching to (i) identify useful parts of a user profile that satisfy services requirements (i.e., input parameters) and (ii) compute the description required by a service to be executed but not provided by the user profile. Our approach, part of the EC-funded project SOA4All, was evaluated on its applicability in real world scenarios with end-users.
Biomass-Derived Adsorbent for Dispersive Solid-Phase Extraction of Cr(III), Fe(III), Co(II) and Ni(II) from Food Samples Prior to ICP-MS Detection (2021)

A biomass-derived adsorbent was simply prepared and applied as efficient and low-cost solid-phase supports. The adsorbent material was characterized by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), surface area analysis and Fourier transform infrared (FTIR) spectroscopy. The amorphous structure of the prepared adsorbent was indicated from the XRD. The prepared adsorbent exhibited surface functional groups such as carbonyl and hydroxyl groups, which enhance the application of DSPE. An accurate separation and preconcentration of Cr(III), Fe(III), Co(II) and Ni(II) prior to ICP-MS detection was achieved using the biomass-derived adsorbent. The extraction process was performed at pH 4 using 1 mL of 0.5 N nitric acid for elution and recovery of ions. The prepared biomass-derived adsorbent showed efficient performance for extraction application, exhibiting a preconcentration factor of 50 and LODs of 1.4, 2.4, 1.9 and 3.0 µg.L−1 for Cr(III), Fe(III), Co(II) and Ni(II), respectively, while the LOQs were reported as 4.1, 7.3, 5.7 and 8.9 µg.L−1 for Cr(III), Fe(III), Co(II) and Ni(II), respectively. The DSPE procedure presented was successfully applied to the determination of the Cr(III), Fe(III), Co(II) and Ni(II) contamination in some food samples.
Integration of a III-V light emitter on a silicon photonic IC through transfer printing (2016)

For the first time, III-V opto-electronic components are coupled to silicon waveguide circuits using transfer-printing. Efficient III-V material usage is enabled in silicon photonics by providing III-V only where needed. We present transfer-printed single-spatial-mode LEDs coupling to silicon-on-insulator waveguides as first examples of this technology.
Carbon Nanotube Nanoelectrode Array for Ultrasensitive DNA Detection (2003)

A reliable nanoelectrode array based on vertically aligned multi-walled carbon nanotubes (MWNTs) embedded in SiO2 is used for ultrasensitive DNA detection. Characteristic nanoelectrode behavior is observed using low-density MWNT arrays for measuring both bulk and surface immobilized redox species such as K4Fe(CN)6. The open-end of MWNTs present similar properties as graphite edge-plane electrodes with wide potential window, flexible chemical functionalities, and good biocompatibility. Oligonucleotide probes are selectively functionalized at the open ends cf the nanotube array and specifically hybridized with oligonucleotide targets. The guanine groups are employed as the signal moieties in the electrochemical measurements. Ru(bpy)3(2+) mediator is used to further amplify the guanine oxidation signal. The hybridization of subattomoles of PCR amplified DNA targets is detected electrochemically by combining the MWNT nanoelectrode array with the Ru(bpy)32' amplification mechanism. This system provides a general platform of molecular diagnostics for applications requiring ultrahigh sensitivity, high-degree of miniaturization, and simple sample preparations.
Correlation between Acoustic Cavitation Noise, Bubble Population, and Sonochemistry (2002)

Quantitative studies of the correlation between sonochemical activity and acoustical noise spectra have been performed. The width of the second harmonic (fwhm2) of the acoustical signal in the frequency domain shows a sensitive dependence to the presence of small amounts (mM range) of an anionic surfactant in water. This sensitive dependence is also observed for other characteristics of the cavitation noise spectrum and in the sonochemical production of peroxides and correlates well with the sonoluminescence intensity observed by other researchers. Analysis of the experimental data shows that SDS probably modifies the coalescence phenomena.
Fourier Transform Mass Spectrometry of Large (m/z >5,000) Biomolecules (1987)

Recent experimental results demonstrate the high mass (>10,000 amu) capabilities of Fourier transform mass spectrometry, however the data reveal non-theoretical limits in the resolution at high mass. These advances can be attributed to the development of methods for coupling high pressure ion sources to the ultra-high vacuum FT-ICR analyser. Specifically, external ion sources permit the utilization of liquid matrix secondary ionization mass spectrometry for the desorption of large involatile, thermally labile biomolecules with ion detection by FT-ICR. Limitations in the mass resolution arise from the inability to effectively trap the ions and produce a coherent packet of ions for detection. The lack of spatial and phase coherence of the injected ions leads to the loss of the frequency domain signal. According to our model, a principle factor contributing to the lack of spatial and phase coherence is field inhomogeneities coupled with the kinetic energies of the ions along the Z-axis.
Reduced graphene oxide catalytically enhances the rate of cyanate ester curing under variable frequency microwave heating (2023)

Abstract The curing of Lonza Primaset PT‐30 novolac cyanate ester resin and EPON 826 bisphenol‐A diglycidyl ether were investigated using convective thermal heating and variable frequency microwave (VFM) heating. The addition of 1 part per hundred reduced graphene oxide (r‐GO) to PT‐30 novolac cyanate ester increased the VFM cure rate compared to thermal heating. Curing it at 160°C for 240 min with VFM heating resulted in a 55% degree of cure compared to a 26% degree of cure with thermal heating. This observed VFM rate enhancement is due to selective microwave heating of the r‐GO particles in the resin resulting in increased r‐GO catalytic activity toward cyanate ester curing. It is both a thermal and catalytic effect, the latter of which is absent when r‐GO is added to a bisphenol‐A diglycidyl ether resin with o ‐phenylenediamine hardener. Impurities present in the PT‐30 matrix do not appear to contribute to its overall cure kinetics, nor do they participate in the observed VFM rate enhancement.