gebhart/patrepeval huggingface dataset:
S100 Calcium-Binding Protein P Secreted from Megakaryocytes Promotes Osteoclast Maturation (2021)

Megakaryocytes (MKs) differentiate from hematopoietic stem cells and produce platelets at the final stage of differentiation. MKs directly interact with bone cells during bone remodeling. However, whether MKs are involved in regulating bone metabolism through indirect regulatory effects on bone cells is unclear. Here, we observed increased osteoclast differentiation of bone marrow-derived macrophages (BMMs) cultured in MK-cultured conditioned medium (MK CM), suggesting that this medium contains factors secreted from MKs that affect osteoclastogenesis. To identify the MK-secreted factor, DNA microarray analysis of the human leukemia cell line K562 and MKs was performed, and S100 calcium-binding protein P (S100P) was selected as a candidate gene affecting osteoclast differentiation. S100P was more highly expressed in MKs than in K562 cells, and showed higher levels in MK CM than in K562-cultured conditioned medium. In BMMs cultured in the presence of recombinant human S100P protein, osteoclast differentiation was promoted and marker gene expression was increased. The resorption area was significantly larger in S100P protein-treated osteoclasts, demonstrating enhanced resorption activity. Overall, S100P secreted from MKs promotes osteoclast differentiation and resorption activity, suggesting that MKs indirectly regulate osteoclast differentiation and activity through the paracrine action of S100P.
ChemInform Abstract: SYNTHESIS OF POMIFERIN, AURICULASIN, AND RELATED COMPOUNDS (1979)

Abstract Aus 3′,4′‐Di‐O‐ methyl‐orobol (I) werden nach bekannten Verfahren über eine Kernprenylierung letztlich die Pflanzeninhaltsstoffe Pomiferin (II) bzw. Auriculasin (III) u.ä.
<title>Source coding of HDTV with compatibility to TV</title> (1990)

Gradual introduction of HDTV is considered to be important. In this paper, a bit-rate reduction system is introduced, which decreases the bit rate of digital HDTV from 664 Mbit/s to about 80 Mbit/s, while ensuring compatibility with TV. The system is based on first subband splitting the interlaced HDTV signal into an interlaced compatible TV signal and three surplus signals. Then, the compatible TV signal is coded with intraframe DCT coding, whereas the surplus signals are coded with quantization, variable-length coding and runlength coding.
Highly sensitive photoalignment of calamitic and discotic liquid crystals assisted by axis-selective triplet energy transfer (2011)

Highly sensitive photoalignment of liquid crystals (LCs) can be realized by axis-selective triplet energy transfer. Addition of a triplet photosensitizer (phosphorescent donor) into a photocrosslinkable polymer tethering E-cinnamate side chains ensures dramatic enhancement of photosensitivity to generate the optical anisotropy of polymer film and surface-assisted LC photoalignment. Photoirradiation of triplet photosensitizer-doped polymer films with linearly polarized 365 nm light for the selective excitation of triplet sensitizer gives rise to optical anisotropy of cinnamates as a result of axis-selective triplet energy transfer. By analyzing phosphorescence spectra with theoretical Perrin's formula, we find that triplet energy transfer is efficient within a radius of ∼0.3 nm from the triplet photosensitizer. Such photoaligned polymer films can be used for the surface-assisted orientation photocontrol of not only calamitic LC, but also discotic LC, even for extremely low exposure energies. The present procedure would be greatly advantageous for high-throughput fabrication of optical devices by photoalignment techniques.
Quality Metrics for Information Visualization (2018)

Abstract The visualization community has developed to date many intuitions and understandings of how to judge the quality of views in visualizing data. The computation of a visualization's quality and usefulness ranges from measuring clutter and overlap, up to the existence and perception of specific (visual) patterns. This survey attempts to report, categorize and unify the diverse understandings and aims to establish a common vocabulary that will enable a wide audience to understand their differences and subtleties. For this purpose, we present a commonly applicable quality metric formalization that should detail and relate all constituting parts of a quality metric. We organize our corpus of reviewed research papers along the data types established in the information visualization community: multi‐ and high‐dimensional, relational, sequential, geospatial and text data. For each data type, we select the visualization subdomains in which quality metrics are an active research field and report their findings, reason on the underlying concepts, describe goals and outline the constraints and requirements. One central goal of this survey is to provide guidance on future research opportunities for the field and outline how different visualization communities could benefit from each other by applying or transferring knowledge to their respective subdomain. Additionally, we aim to motivate the visualization community to compare computed measures to the perception of humans.
Microsoft Windows 2000 Kerberos Change Password and Set Password Protocols (2002)

KRB_PRIV message that contains the new password for the user.
Cyclic vomiting: association with multiple homeostatic abnormalities and response to ketorolac. (1996)

Cyclic vomiting is a rare syndrome that over the years has variously been ascribed to psychogenic causes, sensory seizures, abdominal migraine, and more recently, to mechanical or electrical disturbances in gastric physiology. We describe the case of a 65-year-old white diabetic female with a 10-yr history of recurrent episodes of nausea and vomiting, occurring every 10-12 days and lasting approximately 1-3 days at a time. These episodes were accompanied by edema, mild temperature elevations, and remarkable elevations in blood pressure. In between these episodes, the patient remained asymptomatic. Initial screening tests were also negative except for moderate gastroparesis. However, antral motility was found to be normal, as was an electrogastrogram. Detailed neurological and psychiatric evaluations were negative. Trials of erythromycin, metoclopramide, naloxone, ondansetron, and amitryptiline were unsuccessful. Serial endocrinological testing revealed that an episode of vomiting was always preceded by an abnormal elevation in at least one of the following: serum adrenocorticotropic hormone, serum cortisol, or urinary cortisol. In the midst of an episode, all three values were exceedingly high (e.g., > 10-fold increases in 24-hr urinary cortisol levels). Fluctuations of a milder degree, though still abnormally high, were also noted in between cycles at times when the patient was completely asymptomatic. High-dose dexamethasone suppressed these hormonal surges completely but not the clinical symptoms, which continued undisturbed. The patient was finally given a trial of intramuscular ketorolac during one of her episodes, which produced prompt and sustained relief. During the next few weeks, she was given this drug each time her symptoms commenced, and each time it appeared that her cycle had been aborted. She has since been able to terminate her episodes promptly and completely by self-administration of ketorolac. We speculate that her syndrome is caused by a poorly characterized disorder of endogenous prostaglandin release, resulting not only in derangements in the hypothalamic pituitary system but also in nausea and vomiting.
Strategies for increased donor electrical activity in germanium (opto-) electronic materials: a review (2016)

Germanium is one of the strongest candidate materials for next generation integrated optoelectronic devices owing to its high carrier mobilities, bandgap at the telecom wavelength of 1.55 μm, and monolithic (CMOS) integration with silicon. However, for device applications requiring very high carrier concentrations, such as solid state lasers and MOSFETs, a persistent technological hurdle is the limited electrically active concentration ∼5×1019 cm−3 observed in n-type material, regardless of the chemical concentration of incorporated donors above this. This is due to the formation of donor-vacancy clusters, which electrically compensate the material and enhance dopant diffusivity. In recent years, multiple strategies have attempted to address this, with some, albeit limited, success. Here we outline some of the more novel approaches and provide a review with particular emphasis on one of the more promising of these: the co-implantation of donors with fluorine, and discuss potential methods for optimizing this process.
Identifying and suppressing interfacial recombination to achieve high open-circuit voltage in perovskite solar cells (2017)

Dopants in the hole transport layer limit the open-circuit voltage of perovskite solar cells.
The Staphylococcus aureus ileS gene, encoding isoleucyl-tRNA synthetase, is a member of the T-box family (1997)

The Staphylococcus aureus ileS gene, encoding isoleucyl-tRNA synthetase (IleRS), contains a long mRNA leader region. This region exhibits many of the features of the gram-positive synthetase gene family, including the T box and leader region terminator and antiterminator. The terminator was shown to be functional in vivo, and readthrough increased during growth in the presence of mupirocin, an inhibitor of IleRS activity. The S. aureus ileS leader structure includes several critical differences from the other members of the T-box family, suggesting that regulation of this gene in S. aureus may exhibit unique features.
Effects of Bacillus Thuringiensis Cry Proteins On the Morphology of Western Corn Rootworm (Diabrotica virgifera virgifera) Midgut Cells (2016)

Journal Article Effects of Bacillus Thuringiensis Cry Proteins On the Morphology of Western Corn Rootworm (Diabrotica virgifera virgifera) Midgut Cells Get access Andrew J Bowling, Andrew J Bowling Dow AgroSciences, Indianapolis, IN, 46268 Search for other works by this author on: Oxford Academic Google Scholar Heather E Pence, Heather E Pence Dow AgroSciences, Indianapolis, IN, 46268 Search for other works by this author on: Oxford Academic Google Scholar Alaina M Turchi, Alaina M Turchi Indiana University, Bloomington, IN, 47405 Search for other works by this author on: Oxford Academic Google Scholar Sek Yee Tan, Sek Yee Tan Dow AgroSciences, Indianapolis, IN, 46268 Search for other works by this author on: Oxford Academic Google Scholar Kenneth E Narva Kenneth E Narva Dow AgroSciences, Indianapolis, IN, 46268 Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 22, Issue S3, 1 July 2016, Pages 1208–1209, https://doi.org/10.1017/S1431927616006887 Published: 25 July 2016
Calculus-based transformations of queries over object-oriented views in a database mediator system (1998)

The concept of object-oriented (OO) views has been a popular approach to data integration. Nevertheless, there have been few reported results on optimization of queries over integrated OO views. The authors have developed an OO view system for data integration based on the AMOS database mediator system. The paper describes a system architecture and implementation that takes advantage of query optimization techniques to improve the performance of queries to integrated OO views. The main features of the system are: 1) a passive mediation framework that preserves the autonomy of the data sources. 2) A selective materialization mechanism that minimizes the number of materialized view objects. 3) A predicate based mechanism to guarantee the validity of the materialized view objects as well as the completeness of queries to the view. In order to reduce the overhead of the passive view integration, they use inexpensive calculus based transformations to generate minimal query expressions before the query decomposition and the cost-based algebraic optimization take place.
Novel System for Rapid Assessment of Blood Loss in Elective Surgery and Cesarean Delivery (2014)

INTRODUCTION: Visual and gravimetric methods of estimating blood loss are severely limited by human error and the presence of large volumes of amniotic fluid, irrigation, or both. The study goal was to assess accuracy of a novel system for intraoperative monitoring of hemoglobin (Hb) loss. METHODS: After institutional review board approval, 50 patients undergoing elective surgery or cesarean delivery contributed laparotomy sponges intraoperatively. The iPad-based Triton system was used to measure Hb loss (g) and blood loss (mL) by scanning sponges exiting the surgical field. Hemoglobin loss measured by the device was compared with a rinsing (reference) method using linear regression and Bland-Altman analysis. The device's measure of estimated blood loss was compared with the gravimetric method (weighing sponges) and with health care providers' visual estimates. RESULTS: A strong positive linear correlation was observed between the device's measures and the reference method (r=0.91, P<.001). Bland-Altman analysis revealed a bias of 3.7 g Hb and narrow limits of agreement (−15.3 to 22.7 g Hb) between the two measures. Gravimetric method demonstrated a positive linear correlation (r=0.87, P<.001) with the reference method, yet overestimated mean estimated blood loss by 422 mL per patient (667 compared with 245 mL, P<.001). Visual estimation was weakly correlated (r=0.30, P<.05) with the reference method. CONCLUSION: This novel device may enhance the ability to rapidly and accurately quantitate ongoing bleeding and may enable health care providers to better manage fluid and blood product replacement in the setting of obstetric hemorrhage.
La réforme des institutions locales (2008)

Spire est le dépôt institutionnel de la production scientifique de Sciences Po et contient le texte intégral des articles, ouvrages, chapitres d’ouvrages, working papers et communications dans des conférences de la communauté académique de Sciences Po.
Abstract A013: Haploidentical stem cell transplantation and subsequent immunotherapy with antiGD2 antibody for patients with relapsed metastatic neuroblastoma (2019)

Abstract Background: Pediatric patients with relapsed metastatic neuroblastomas have a poor prognosis and additional strategies are needed. We present results of a phase I/II-trial with subsequent immunotherapy with an anti-GD2mAb (CH14.18/CHO) after HLA-mismatched, haploidentical stem cell transplantation (SCT). Methods: T- and B-cell depleted stem cells from parental donors were used in combination with melphalan 140mg/m², thiotepa 10mg/kg, fludarabin 160mg/m² and ATG-F. CH14.18/CHOmAb was started on day 60-180 post-transplant: 6 cycles with 20mg/m²/day x 5; in cycles 4-6, 1x106 U/m² Interleukin 2 was given additionally. Disease status was evaluated with whole body MRI, MIBG scan and MRD detection in bone marrow aspirates. Primary endpoint was success of treatment, defined as a patient receiving the full protocol treatment, still alive 180 days after end of treatment without progression/unacceptable toxicity or severe GvHD. Results: 56 patients with 1st or ≥2nd metastatic relapse were enrolled. Disease status prior to antibody infusions was: CR (n=19), PR (n=31), mixed (n=6). 41% of patients with measurable tumor burden responded and reached CR after treatment. 90% of patients with initial CR could maintain this status. In total, success of treatment was observed in 60%. 3-year OS and EFS was 58% and 45%, respectively. Causes of death were: progression/relapse (25%) or TRM (7%). Factors of influence on EFS were (1) remission status prior to SCT (with CR, PR or mixed response resulting in 70%, 45% and 11% 3yEFS) and (2) bone marrow involvement prior to CH14.18 treatment (no MRD detectable: 60% 3yEFS vs. any MRD detectable: 20% 3yEFS). Frequent side effects were pain, fever, CRP elevation; rare side effects comprised SIRS/capillary leak syndrome, seizures, accommodation disturbances. Transient acute severe GvHD occurred in 1 patient. Conclusions: CH14.18/CHO infusions after haploidentical SCT are feasible with acceptable toxicity. Our results suggest an antitumor effect of the new, donor-derived immune system in combination with CH14.18 treatment. Citation Format: Peter Lang, Tim Flaadt, Martin Ebinger, Patrick Schlegel, Holger Lode, Ruth Ladenstein, Anne-Marie Lang, Peter Ambross, Juergen Schaefer, Joerg Fuchs, Hans Loibner, Wolfgang Schwinger, Rupert Handgretinger. Haploidentical stem cell transplantation and subsequent immunotherapy with antiGD2 antibody for patients with relapsed metastatic neuroblastoma [abstract]. In: Proceedings of the Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; Sept 30-Oct 3, 2018; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2019;7(2 Suppl):Abstract nr A013.
Building the bench: developing the leadership capacity of assistant principals (2020)

Our disquisition is founded in both the leadership literature and empirical data from four North Carolina school districts. Our work and the literature suggest that support is needed for assistant principals to develop their leadership capacity and prepare them for the principalship (Chan, Webb, &amp; Bowen, 2003; Leithwood, Louis, Anderson, &amp; Wahlstrom, 2004). We utilized improvement science methods to identify a problem of practice to be addressed with an improvement initiative (Bryk, Gomez, Grunow, LeMaheiu, 2016). Our improvement initiative was employed through a combined framework of succession planning (Lynn, 2001; Peters, 2011) and social justice leadership theory (Theoharis, 2007; 2009). Called the Assistant Principal Professional Leadership Experience (APPLE), our implementation consisted of three components including an orientation session, monthly professional development sessions, and shadowing experiences. Utilizing a PDSA (Plan-Do-Study-Act) approach, we collected data throughout the initiative to make decisions. Using both qualitative (interviews, focus groups)and quantitative instruments (surveys), we analyzed the pre-initiative and post-initiative data to find statistically significant growth in several leadership areas, including: equity, student assessment, teacher evaluation, teacher remediation, data-driven decision making, studentdecision making, and school safety. The data showed mean increases in assistant principalcreated goals as well as increases in the pre- and post-measurements of the North CarolinaStandards for School Executives. The qualitative and quantitative shadowing data showed positive findings that acknowledged the success of the experience.Keywords: leadership, assistant principals, administrator support, shadowing, professional development, orientation, succession planning model, social justice leadership
Characterization of the Different Electrophoretic Forms of the Cadang-Cadang Viroid (1982)

SUMMARY The relationship between symptom development and changes in the fast and slow electrophoretic forms of the two cadang-cadang disease-associated RNAs (ccRNA-1 and ccRNA-2) has been examined. The fast form of each is present in trees for up to 2 years before the appearance of symptoms, indicating an incubation period of about 2 years. Trees showing the first symptoms (on the nuts) contain only the fast form of the ccRNAs; the development of leaf symptoms coincides with the first detection of the slow form. After this time, both slow and fast forms are found in the newly developing fronds for the next 9 to 12 months but then, as symptoms develop, new fronds contain only the slow form. Therefore, at later stages of disease, only the slow form can be detected in all fronds. The fast form of ccRNA-1 and/or ccRNA-2 therefore appears to be the infectious form in nature. The number of nucleotides in the four ccRNAs as determined by polyacrylamide gel electrophoresis under denaturing conditions are: ccRNA-1 fast, 250; ccRNA-1 slow, 300; ccRNA-2 fast, 500; ccRNA-2 slow, 600. On the basis of two-dimensional fingerprints of ribonuclease A and T1 digests of the four ccRNAs, it was concluded that the ccRNAs are composed of repeated sequences of ccRNA-1 fast, and each of the ccRNA-2 forms is a dimer of the respective ccRNA-1 form.
EFFICACY AND SAFETY OF ASACOL 4.8G/DAY (800 MG TABLET) COMPARED TO 2.4 G/DAY (400 MG TABLET) IN TREATING MODERATELY ACTIVE ULCERATIVE COLITIS (2004)

Purpose: To assess the efficacy and safety of mesalamine delayed-release tablets (Asacol) dosed at 4.8 g/day using a newly formulated 800 mg mesalamine tablet compared with Asacol 2.4 g/day dosed using the currently marketed 400 mg tablet in the treatment of moderately active ulcerative colitis. Methods: This was a prospective, multi-center, randomized, double-blind, positive-controlled clinical trial. Male and female patients 18–75 years old, with a confirmed diagnosis of ulcerative colitis within 24 months prior to study entry were randomized to receive either Asacol 4.8 g/day (800 mg tablet) or 2.4 g/day (400 mg tablet) for 6 weeks. The primary endpoint of the study was the percentage of patients in each treatment group who achieved treatment success at the end of the study. Treatment success was defined as complete or partial response to therapy, based on clinical, endoscopic, and physician assessments. Results: A total of 268 patients with moderately active disease were randomly assigned to either the 2.4 g/day (n = 139) or the 4.8 g/day (n = 129) group, of which 254 patients were eligible for analysis. There were no statistically significant differences for any baseline demographic or an-thropometric characteristic or history of ulcerative colitis between patients enrolled into the two treatment groups. At the end of the study, success was achieved in 71.8% (89/124) of patients in the 4.8 g/day group and 59.2% (77/130) of patients in the 2.4 g/day group (p = 0.0357). The higher dose of Asacol was not associated with an increase in severity or frequency of adverse events or meaningful changes in laboratory results. Conclusions: Overall, the study results demonstrated that in the treatment of patients with moderately active ulcerative colitis, Asacol 4.8 g/day (800 mg tablet) was significantly more efficacious than Asacol 2.4 g/day (400 mg tablet). Both treatment groups showed comparable safety profiles.
Identification of a Novel cDNA Clone Encoding Protein Tyrosine Kinase in Murine Skin (1994)

Tyrosine phosphorylation is widely recognized as playing important roles in cell differentiation, proliferation, and carcinogenesis. We have used the polymerase chain reaction (PCR) method to identify protein tyrosine kinases that are expressed in the skin. Mixed oligonucleotide probes were used to amplify and screen a neonatal murine skin cDNA pool for clones encoding amino acid contiguities whose conservation is characteristic of the protein tyrosine kinase family. When the PCR products were sequenced, 13 distinct clones were found, of which one is novel to date and has provisionally been named tks (for tyrosine kinase identified from skin). Sequence homology comparison showed that the tks gene is homologous to the src and fes/fps families. Northern blotting using PCR products of tks as a probe revealed that the mRNA of tks is detected ubiquitously and weakly in other tissues such as brain, lung, liver, thymus and kidney. This fact suggests that the tks gene is expressed in widely distributed cell types.
supplemental Table 1 from Generation 2.5 Antisense Oligonucleotides Targeting the Androgen Receptor and Its Splice Variants Suppress Enzalutamide-Resistant Prostate Cancer Cell Growth (2023)

&lt;p&gt;supplemental Table 1. A list of primers used in the quantitative real-time PCR in this study.&lt;/p&gt;