gebhart/patrepeval huggingface dataset:
A Physical Pulverization Strategy for Preparing a Highly Active Composite of CoOx and Crushed Graphite for Lithium–Oxygen Batteries (2014)

A new physical pulverization strategy has been developed to prepare a highly active composite of CoOx and crushed graphite (CG) for the cathode in lithium-oxygen batteries. The effect of CoOx loading on the charge potential in the oxygen evolution reaction (Li(2)O(2) →2 Li(+) +O(2) +2e(-)) was investigated in coin-cell tests. The CoOx (38.9 wt %)/CG composite showed a low charge potential of 3.92 V with a delivered capacity of 2 mAh cm(-2) under a current density of 0.2 mA cm(-2). The charge potential was 4.10 and 4.15 V at a capacity of 5 and 10 mAh cm(-2), respectively, with a current density of 0.5 mA cm(-2). The stability of the electrolyte and discharge product on the gas-diffusion layer after the cycling were preliminarily characterized by (1)H nuclear magnetic resonance spectroscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, and X-ray diffraction. The high activity of the composite was further analyzed by electrochemical impedance spectroscopy, cyclic voltammetry, and potential-step chronoamperometry. The results indicate that our near-dry milling method is an effective and green approach to preparing a nanocomposite cathode with high surface area and porosity, while using less solvent. Its relative simplicity compared with the traditional solution method could facilitate its widespread application in catalysis, energy storage, and materials science.
Enhancing graft-versus-leukemia after transplant: the rise of anti-cancer vaccines (2011)

Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only truly effective curative treatment for refractory hematological malignancies. Unfortunately, relapse and transplant rejection continue to be of major concern. In order to enhance the effectiveness of the HSCT, various strategies have been explored to amplify the graft versus leukemia (GvL) effect. Cancer vaccines have emerged in recent years as a promising strategy for the immunotherapeutic treatment of cancer. Evidence shows that they are most likely to have the greatest effect in the setting of minimal residual disease and as adjuvant agents. With this in mind, researchers have begun to explore the use of cancer vaccines in conjunction with HSCT, with exciting results. There has also been recent work examining the effect of novel adjuvants or blockers of negative immune regulation to augment the effect of cancer vaccines in both the transplant and non-transplant settings. The addition of these agents may prove.
MAPPING QTL WITH COVARIATES (2009)

Quantitative trait loci (QTL) analysis is an effective tool for locating regions of the genome associated with a trait. Quantitative trait data are complex, and when statistically testing for the location of a QTL, the distribution of the test statistic is typically unknown. Historically, asymptotic thresholds have been difficult to derive for QTL analysis. Permutation testing has successfully provided significance thresholds for QTL analysis, but the need for exchangeability among the observations limits these empirically derived thresholds to simple linear models and does not permit the inclusion of important covariates in the model. We address the limitation of permutation theory for supplying empirically derived QTL significance threshold using a novel bootstrap threshold that is appropriate for multiple regression based interval mapping models. Simulation studies demonstrate that the proposed bootstrap thresholds improve detection and estimation of additive effects in QTL studies.
Inside Cover: Self‐Assembly of One‐ and Two‐Dimensional Hemoprotein Systems by Polymerization through Heme–Heme Pocket Interactions (Angew. Chem. Int. Ed. 7/2009) (2009)

Abstract Supramolecular protein polymers consisting of cytochrome b 562 monomers with heme covalently attached to the protein surface are presented by T. Hayashi and co‐workers in their Communication on page 1271 ff. Not only one‐dimensional hemoprotein fibers with submicrometer lengths have been prepared, but when a heme triad was added as a pivot molecule, two‐dimensional protein assembly networks resulted, which cover over 100 square micrometers. magnified image
Computerized features of spatial arrangement of tumor-infiltrating lymphocytes from H&E images predicts survival and response to checkpoint inhibitors in gynecologic cancers. (2020)

6074 Background: Immune checkpoint inhibitors (ICI) have demonstrated success in solid tumors. In gynecologic cancers (GC), the response rate is still low (~10-15%) except in MSI-H endometrial cancer (~ 50%). Current biomarkers (e.g. PDL1 expression) have limited utility in identifying benefit from ICI in GC. In this work we evaluated the ability of computational measurements of spatial arrangement of tumor infiltrating lymphocytes (TIL) from H&amp;E slide images in predicting overall survival (OS) and response to ICI in ovarian, cervical and endometrial cancers. Methods: The study included 151 patients, including 102 ovarian carcinomas treated with surgery and chemotherapy (D1) and another set (D2) of n=49 patients (n=14 ovarian, n=27 endometrial and n=8 cervical), treated with different ICI agents (Pembrolizumab, Nivolumab, Ipilimumab, Avelumab) in the second line setting. Progressors and non-progressors in D2 were classified according to clinical improvement and radiologic assessment by RECIST. A machine learning approach was employed to identify tumor regions on the diagnostic slides from D1 and D2 and then used to automatically identify TILs within the tumor regions. Subsequently machine learning was used to define TIL clusters based on TIL proximity, and graph network theory was used to capture measurements relating to spatial arrangement of TIL clusters. The multivariable Cox regression model (MCRM) was trained on n=51 patients from D1 to predict OS and then independently evaluated in predicting (1) OS on the hold-out n=51 patients in D1 and (2) response and progression-free survival (PFS) in D2. Results: Statistical analysis identified 7 prognostic features relating to interaction of TIL clusters with cancer nuclei. MCRM was prognostic of OS on the n=51 hold out patients in D1 (hazard ratio (HR)=2.06, 95% confidence interval [1.04- 4.07], p=0.008) and predictive of PFS in D2 (HR=2.24, CI=[1.13-4.44], p=0.03). The AUC for MCRM in predicting progression in D2 was 82%. Conclusions: Computerized features of spatial arrangement of TILs on H&amp;E images were prognostic of OS and PFS and predicted response to ICI in three gynecological cancers. These findings need to be validated in larger, multi-site validation sets. [Table: see text]
Discovery of Hepatitis C Virus NS3-4A Protease Inhibitors with Improved Barrier to Resistance and Favorable Liver Distribution (2013)

Given the emergence of resistance observed for the current clinical-stage hepatitis C virus (HCV) NS3 protease inhibitors, there is a need for new inhibitors with a higher barrier to resistance. We recently reported our rational approach to the discovery of macrocyclic acylsulfonamides as HCV protease inhibitors addressing potency against clinically relevant resistant variants. Using X-ray crystallography of HCV protease variant/inhibitor complexes, we shed light on the complex structural mechanisms by which the D168V and R155K residue mutations confer resistance to NS3 protease inhibitors. Here, we disclose SAR investigation and ADME/PK optimization leading to the identification of inhibitors with significantly improved potency against the key resistant variants and with increased liver partitioning.
eling of Piezoceramic and S rgr (1995)

Smart materials such as piezoceramics and shape memory alloys (SMAs) exhibit significant hysteresis and in order to estimate the effect on open and closed loop control a suitable model is needed. One promising candidate is the Preisach independent domain hysteresis model that is characterized by the congruent minor loop and wiping out properties. Comparable minor loop and decaying oscillation test data for a multi-sheet piezoceramic actuator (made of lead zirconate titanate) attached to a flexible beam are presented and are seen to be very consistent with the two Preisach model properties. The commanded parameter is the sheet transverse electric field while the measured parameter is an approximately colocated strain induced in the beam. Equivalent data for a Nitinol SMA wire muscle, attached to the same beam, are also presented. The input and output parameters are the SMA current and a beam strain respectfully. The minor loop and wiping out evidence is less strong than that of the piezoceramic case, but encouraging. In all experiments the quasi-steady state responses were generated in order to avoid exciting beam flexible modes which would complicate the analysis.
The Role of Scanning Probe Microscopy in Drug Delivery Research (1996)

The success of a drug delivery system is often dependent on the surface properties of the device. These surface properties will determine the complex dynamic interfacial events that occur when the system is introduced into the aqueous environment of a patient. Development of the scanning probe microscopes has provided a number of very powerful new surface analytical techniques that are making a significant contribution to the characterization of drug delivery systems and the interfacial processes that occur when such systems are exposed to aqueous living environments. In this review, we describe the design and attributes of these instruments and discuss the impact of the techniques on a wide range of drug delivery research. The scanning probe microscopes are providing new insights into important problems concerning drug delivery, including the molecular structure of polymeric biomaterial surfaces, the conformation of target biomolecules, the influence of morphology on biodegradation, the adsorption of proteins to synthetic surfaces, and the structure and interactions of colloidal particles. As the whole field of scanning probe microscopy continues to advance, drug delivery research is set to benefit; in the final section of the review, the future potential derived from the ability to characterize new surface properties under aqueous conditions is discussed.
Lymphovascular Infiltration, Not Depth of Invasion, is the Critical Risk Factor of Metastases in Early Colorectal Cancer: Retrospective Population-based Cohort Study on Prospectively Collected Data, Including Validation. (2022)

This is a large study on LNM in T1 CRC, including validation, showing that LVI and perineural invasion, mucinous subtype, and low age constitute independent risk factors, whereas depth of submucosal invasion is not an independent risk factor of LNM. Thus, our findings provide a useful basis for management of patients after local excision of early CRC.
Combinatorial and High-Throughput Development of Polymer Sensor Coatings for Resonant and Optical Sensors (2007)

Polymeric sensor materials are attractive in a variety of sensors including resonant and optical devices. Polymeric sensor materials play a critical role in the effort to advance selectivity, response speed, and sensitivity of chemical and biological determinations in gases and liquids. Desirable capabilities of polymeric sensor materials originate from their numerous functional parameters, which can be tailored to meet specific needs. However, when the functional complexity of polymeric sensor materials increases, the ability to rationally design preferred materials properties ecomes increasingly limited. In this study, we demonstrate new opportunities in polymer sensor materials research for resonant and optical sensors that were opened up with the use of combinatorial and high-throughput experimentation methodologies.
Palladacycles as Efficient Catalysts for Aryl Coupling Reactions (1995)

The catalytic CC coupling of chloroarenes by both the Heck and the Suzuki reactions has been achieved for the first time with new palladacycles of type 1, in which R can be, for instance, o-tolyl or mesityl. They are an order of magnitude more active than conventional catalysts and, moreover, thermally considerably more robust. But above all, the cleavage of the PC bond and the deposition of palladium is not observed. Analogous reactions with bromoarenes can also be catalyzed to advantage with 1. The Heck reaction of haloarenes with vinyl derivatives (e.g., n-butyl acryiate) gives (E)-styrene derivatives in one step. In the Suzuki reaction the haloarenes are converted into biphenyl derivatives with phenylbornic acid, also in one step.
Spherical Aberrations of Human Astigmatic Corneas (2011)

Mean spherical aberration of astigmatic corneas was not correlated significantly with cylinder power or age (P>.05). Spherical aberrations are similar to those of nonastigmatic corneas, permitting the use of these additional data in the design of aspheric toric intra-ocular lenses.
Modelling the effect of time varying organ deformations in head and neck cancer using a PCA model (2019)

Throughout the radiotherapy treatment process, geometrical changes in the patient often occur, e.g. organs&#13;\ndiffering in shape from that of the planning CT scan (pCT). This organ deformation leads to uncertainties&#13;\nin the dose distribution throughout the treatment course. We present a method to statistically model the time&#13;\ndependent effect of organ deformation on organ at risk (OAR) dose, with the aim of later incorporating it&#13;\ninto advanced treatment planning methods i.e. probabilistic planning.
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies (2022)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged <70 y and in >4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death.
Abstract 4413: STX140 is an orally bioavailable microtubule targeting agent with no associated peripheral neuropathy and potent anti-metastasis efficacy in vivo (2010)

Abstract There is a continued need for orally bioavailable anti-cancer compounds that exhibit good efficacy and with a more favourable toxicity profile than current ‘traditional’ cytotoxics. The microtubule disruptor, STX140 has previously been shown to have excellent oral bioavailability and significantly reduce tumor growth in vivo. These data presented here show STX140 to: lack significant neuropathy in a validated in vivo behavioural model and to significantly reduce metastasis in a highly aggressive orthotopic model of breast cancer. To assess the potential for neurotoxicity animals were dosed with, vehicle (0.5% methlycellulose), STX140 (20 mg/kg p.o. 5/7 × 4) or Taxol (15 mg/kg i.v weekly x 4). Thermal hyperalgesia, as assessed by paw withdrawal latency, was measured every 3-4 days using Hargreaves Plantar equipment. The 4T1 murine tumor cell line was used to establish orthotopic tumors in the mammary fad pads of nude mice. After 28 days dosing, as above, tumor size, number of lung and liver metastasises were recorded. Additionally relative levels of circulating tumor cells (CTCs) were assessed by quantifying the number of viable tumor cell colonies grown from 30 µL of blood taken by cardiac puncture at day 28. In the thermal hyperalgesia model of neuropathy Taxol caused a significant decrease in paw withdrawal latency from day 14 till the end of study, in contrast there were no significant changes in withdrawal times in either the vehicle or STX140 dosed groups. In the 4T1 xenograft study both Taxol and STX140 reduced, tumor volume, extent of lung metastasis and number of viable CTCs in the blood relative to vehicle. In a separate study STX140 but not Taxol caused a significant improvement in survival. These studies highlight the excellent efficacy of the orally bioavailable anti-cancer agent STX140 in a highly aggressive model of breast cancer. STX140 may offer a major additional advantage over existing drugs as the most common dose limiting toxicity of neuropathy, is negated / minimised. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4413.
Minimizing a weighted error criterion for spatial error concealment of missing image data (2005)

In this contribution we present an algorithm for spatial error concealment of lost image data caused by transmission of images in error prone environments. The surrounding correctly received image signal is approximated by a weighted linear combination of basis functions and the missing image data is obtained by a frequency selective extrapolation. During the approximation a novel weighted error criterion is minimized. We use an isotropic correlation model for the weighting function taking the correlation among pixels into account and emphasizing pixels which are closer to the missing area. 2D DFT basis functions are especially suited for the signal extrapolation in order to be able to reconstruct monotone areas, edges and noisy regions and allow an efficient realization of the algorithm in the frequency domain. Due to the weighting function we could improve the concealing performance of the algorithm considerably while halving the required FFT size.
Field PMU Test and Calibration Method– Part I: General Framework and Algorithms for PMU Calibrator (2022)

Laboratory testing of phasor measurement units (PMUs) guarantees their performance under laboratory conditions. However, many factors may cause PMU measurement problems in actual power systems, resulting in the malfunction of PMU-based applications. Therefore, field PMUs need to be tested and calibrated to ensure their performance and data quality. In this paper (Part I), a general framework for the field PMU test and calibration in different scenarios is proposed. This framework consists of a PMU calibrator and an analysis center, where the PMU calibrator provides the reference values for PMU error analysis. Two steps are implemented to ensure the calibrator accuracy for complex field signals: <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\textcircled{1}$</tex> by analyzing the frequency-domain probability distribution of random noise, a Fourier-transform-based signal denoising method is proposed to improve the anti-interference capability of the PMU calibrator; and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\textcircled{2}$</tex> a general synchrophasor estimation method based on complex bandpass filters is presented for accurate synchrophasor estimations in multiple scenarios. Simulation and experimental test results demonstrate that the PMU calibrator has a higher accuracy than that of other calibrator algorithms and is suitable for field PMU test. The analysis center for evaluating the performance of field PMUs and the applications of the proposed field PMU test system are provided in detail in Part II of the next-step research.
The N-Terminal Subdomain of Insulin-like Growth Factor (IGF) Binding Protein 6. Structure and Interaction with IGFs (2007)

Insulin-like growth factor binding proteins (IGFBPs) modulate the activity and distribution of insulin-like growth factors (IGFs). IGFBP-6 differs from other IGFBPs in being a relatively specific inhibitor of IGF-II actions. Another distinctive feature of IGFBP-6 is its unique N-terminal disulfide linkages; the N-domains of IGFBPs 1-5 contain six disulfides and share a conserved GCGCC motif, but IGFBP-6 lacks the two adjacent cysteines in this motif, so its first three N-terminal disulfide linkages differ from those of the other IGFBPs. The contributions of the N- and C-domains of IGFBP-6 to its IGF binding properties and their structure-function relationships have been characterized in part, but the structure and function of the distinctive N-terminal subdomain of IGFBP-6 are unknown. Here we report the solution structure of a polypeptide corresponding to residues 1-45 of the N-terminal subdomain of IGFBP-6 (NN-BP-6). The extended structure of the N-terminal subdomain of IGFBP-6 is very different from that of the short two-stranded beta-sheet of the N-terminal subdomain of IGFBP-4 and, by implication, the other IGFBPs. NN-BP-6 contains a potential cation-binding motif; lanthanide ion binding was observed, but no significant interaction was found with physiologically relevant metal ions like calcium or magnesium. However, this subdomain of IGFBP-6 has a higher affinity for IGF-II than IGF-I, suggesting that it may contribute to the marked IGF-II binding preference of IGFBP-6. The extended structure and flexibility of this subdomain of IGFBP-6 could play a role in enhancing the rate of ligand association and thereby be significant in IGF recognition.