gebhart/patrepeval huggingface dataset:
Developpement de stents bioactifs par fixation permanente ou temporaire de dextranes fonctionnalisés (2003)

L'emploi de stents dans les traitments curatifs des stenoses vasculaires est actuellemnt limite par un taux imortant de restenose. Recemment, le developpemnt de stents a liberation de principes actifs a fait l'objet de nombreux travaux afin de limiter la restenose. Les dexranes, polysacharides comoses d'unites a-D-glucopyrannose reliees entre elles par des liaisons a(1-6) sont couramment utilises dans le domaine biomedical. La substitution statistique de certains groupements hydroxyles du dextrane confere a ce polymere des proprietes biologiques efficaces dans la prevention dela restenose. Le but de ce travail a donc etait de immobiliser un dextrane fonctionnalise sur la surface metallique de stents afin de reduire les risques de restenose. Cette immobilisation a ete effectuee selon deux methodes. D'une part le derive du dextrane a ete immobilise de maniere covalente sur la surface metallique. D'autre part la surface du stent a ete enrobee d'u film de dextrane fonctionnalise associe au collagene. Dans ce cas, une augmentation de la concentration a la surface du stent et une liberation controlee du dextrane fonctionnalise au sein du flux sanguin sont observees. L'etude a exige de mettre en place une analyse des surfaces traitees par differentes methodes physicochimiques et biologiques. Les surfaces se sont revelees homogenes en condition in-vitro vis a vis des differents facteurs de la restenose. Leurs proprietes biologiques vis a vis de la restenose ont permis de developper des experimentations in-vivo chez l'animal
Quantitative Susceptibility Mapping Using the Multiple Dipole-inversion Combination with k-space Segmentation Method (2017)

Quantitative susceptibility mapping (QSM) is a new magnetic resonance imaging (MRI) technique for noninvasively estimating the magnetic susceptibility of biological tissue. Several methods for QSM have been proposed. One of these methods can estimate susceptibility with high accuracy in tissues whose contrast is consistent between magnitude images and susceptibility maps, such as deep gray-matter nuclei. However, the susceptibility of small veins is underestimated and not well depicted by using the above approach, because the contrast of small veins is inconsistent between a magnitude image and a susceptibility map. In order to improve the estimation accuracy and visibility of small veins without streaking artifacts, a method with multiple dipole-inversion combination with k-space segmentation (MUDICK) has been proposed. In the proposed method, k-space was divided into three domains (low-frequency, magic-angle, and high-frequency). The k-space data in low-frequency and magic-angle domains were obtained by L1-norm regularization using structural information of a pre-estimated susceptibility map. The k-space data in high-frequency domain were obtained from the pre-estimated susceptibility map in order to preserve small-vein contrasts. Using numerical simulation and human brain study at 3 Tesla, streaking artifacts and small-vein susceptibility were compared between MUDICK and conventional methods (MEDI and TKD). The numerical simulation and human brain study showed that MUDICK and MEDI had no severe streaking artifacts and MUDICK showed higher contrast and accuracy of susceptibility in small-veins compared to MEDI. These results suggest that MUDICK can improve the accuracy and visibility of susceptibility in small-veins without severe streaking artifacts.
INTREPID program: technology and architecture for next-generation, energy-efficient, hyper-scale data centers [Invited] (2021)

The INTREPID program is developing power-efficient coherent optics for package-level integration with future switch integrated circuits as a path to realizing higher-radix switches for flatter networks. The link architecture is underpinned by coherent quadrature phase-shift keying (QPSK) polarization-multiplex transceivers at 200 Gb/s per <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mi>λ</mml:mi> </mml:math> , further enhanced with wavelength division multiplexing (WDM) to enable energy-efficient 800 or 1600 Gb/s inter-switch fiber connections. The technology is compatible with conventional three-level data center designs as well as a two-level data center design introduced here, which includes an added layer of passive, arrayed waveguide grating routers (AWGRs) or WDM circuit switches to further improve the cost, energy efficiency, and latency of the network.
Dataset from Ranucci M, Sitzia C, Baryshnikova E, Di Dedda U, Cardani R, Martelli F, Corsi Romanelli M. Covid-19-Associated Coagulopathy: Biomarkers of Thrombin Generation and Fibrinolysis Leading the Outcome. J Clin Med. 2020 Oct 28;9(11):3487. doi: 10.3390/jcm9113487. PMID: 33126772; PMCID: PMC7692774. (2021)

Dataset from the article Ranucci M, Sitzia C, Baryshnikova E, Di Dedda U, Cardani R, Martelli F, Corsi Romanelli M. Covid-19-Associated Coagulopathy: Biomarkers of Thrombin Generation and Fibrinolysis Leading the Outcome. J Clin Med. 2020 Oct 28;9(11):3487. doi: 10.3390/jcm9113487. PMID: 33126772; PMCID: PMC7692774. <strong>Abstract</strong> <em>Background:</em> Coronavirus Disease 2019 (COVID-19)-associated coagulopathy is characterized by a prothrombotic state not yet comprehensively studied. We investigated the coagulation pattern of patients with COVID-19 acute respiratory distress syndrome (ARDS), comparing patients who survived to those who did not. <em>Methods:</em> In this prospective cohort study on 20 COVID-19 ARDS patients, the following biomarkers were measured: thrombin generation (prothrombin fragment 1 + 2 (PF 1 + 2)), fibrinolysis activation (tissue plasminogen activator (tPA)) and inhibition (plasminogen activator inhibitor 2 (PAI-2)), fibrin synthesis (fibrinopeptide A) and fibrinolysis magnitude (plasmin-antiplasmin complex (PAP) and D-dimers). Measurements were done upon intensive care unit (ICU) admission and after 10-14 days. <em>Results:</em> There was increased thrombin generation; modest or null release of t-PA; and increased levels of PAI-2, fibrinopeptide A, PAP and D-dimers. At baseline, nonsurvivors had a significantly (<em>p</em> = 0.014) higher PAI-2/PAP ratio than survivors (109, interquartile range (IQR) 18.1-216, vs. 8.7, IQR 2.9-12.6). At follow-up, thrombin generation was significantly (<em>p</em> = 0.025) reduced in survivors (PF 1 + 2 from 396 pg/mL, IQR 185-585 to 237 pg/mL, IQR 120-393), whereas it increased in nonsurvivors. Fibrinolysis inhibition at follow-up remained stable in survivors and increased in nonsurvivors, leading to a significant (<em>p</em> = 0.026) difference in PAI-2 levels (161 pg/mL, IQR 50-334, vs. 1088 pg/mL, IQR 177-1565). <em>Conclusion:</em> Severe patterns of COVID-19 ARDS are characterized by a thrombin burst and the consequent coagulation activation. Mechanisms of fibrinolysis regulation appear unbalanced toward fibrinolysis inhibition. This pattern ameliorates in survivors, whereas it worsens in nonsurvivors.
3.7 ps pulse generation at ≥ 30 GHz by dual-driveelectroabsorption modulator (2000)

The authors describe optical short pulse generation at frequencies ≥ 30 GHz by a dual-drive scheme of a high-saturation power travelling-wave electroabsorption modulator. Sub-4 ps almost-transform-limited pulses are achieved with &gt; 20 dB dynamic extinction ratio and low polarisation sensitivity.
Live demonstration: Inexpensive 1024-channel 3D telesonography system on FPGA (2017)

Volumetrie ultrasound (US) is a very promising development of medical US imaging. An under-exploited advantage of volumetric US is the mitigation of the strict probe positioning constrains necessary to acquire 2D scans, potentially allowing the decoupling of US image acquisition and diagnosis. However, today's 3D US systems are large and beset by high power and cost requirements, making them only available in well-equipped hospitals. In this work [1], [2], we propose the first telesonography-capable medical imaging system that supports up to 1024 channels, on par with the state of the art. As a first embodiment, we have implemented our design in a single development FPGA board of 26.7cm × 14cm × 0.16cm, with an estimated power consumption of 6.1 W. The imager exploits a highly scalable architecture which can be either downscaled for 2D imaging, or further upscaled on a larger FPGA. Moreover, our design supports two types of data inputs: real-time via an optical connection and offline over Ethernet. The reconstructed images can be visualized on an HDMI screen. The estimated cost of the proposed prototype materials is less than 4000€. TABLE I shows the resources utilization of the current design and the extrapolated utilization in case of further upscaling on a larger FPGA.
Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation (1998)

We examined the roles of CD80 (B7-1) and CD86 (B7-2) in a model of allergic pulmonary inflammation and airway hyper-responsiveness (AHR) by selectively inhibiting either CD80 or CD86. Inhibition of co-stimulation by either CD80 or CD86 affected multiple parameters of the allergic response. Specifically, blockade of either CD80 or CD86 in ovalbumin-sensitized and challenged mice resulted in reduced expression of IL-2Ralpha (CD25) on CD4+ T lymphocytes, decreased airway eosinophilia, lower serum IgE production and diminished AHR. Importantly, blockade of CD80 and CD86 inhibited production of IL-4 and IL-2, and enhanced IFN-gamma production. Our observations support a role for both CD80- and CD86-mediated co-stimulation in development of allergic pulmonary inflammation.
Study of the Gordon&#x2013;Mollenauer Effect and of the Optical-Phase-Conjugation Compensation Method in Phase-Modulated Optical Communication Systems (2010)

Optical phase-modulated systems are promising candidates for the development of ultrahigh-bit-rate transmission links, thanks to their high spectral efficiency and increased tolerance to fiber-optic nonlinearities. However, their implementation was considerably slowed down by theoretical studies, suggesting that the transmission performance can be severely hindered by nonlinear phase noise (the so-called Gordon-Mollenauer effect). The simulations presented here show that, in realistic systems (including nonlinearity, dispersion, and attenuation), Gordon-Mollenauer noise does not represent the main source of signal distortions. We demonstrate that all nonlinear impairments can be efficiently compensated by optical phase conjugation, independent of system characteristics. The combination of optical-phase-conjugation with phase-modulation formats could enable ultrahigh-transmission-capacity and easy embedded-link upgrading.
Effect of Rimantadine on Influenza Virus Replication (1979)

SummaryRimantadine hydrochloride in concentrations up to 50 μg/ml inhibits the replication of A/WSN influenza virus in MDCK cells without causing visible cytopathic effects. Virus replication was inhibited when the drug was added immediately following infection, but not when added late in the replicative cycle. Rimantadine does not alter the structural integrity of influenza virus as measured by sedimentation profiles of purified virus in linear sucrose gradients. Addition of drug following the viral adsorption period blocked the stimulation of cellular DNA-dependent RNA polymerase II activity observed in untreated infected cells, but had no effect on RNA polymerase II activity isolated from uninfected cell nuclei. Rimantadine present 0-8 hr postinfection inhibited the formation of viral RNA-dependent RNA polymerase activity in infected cells, but when this enzyme was assayed in vitro, rimantadine at concentrations as high as 250 μg/ml did not significantly inhibit polymerase activity. Finally, rimantadin...
Resonant-cavity-enhanced mid-infrared photodetector on a silicon platform (2010)

In this paper, we demonstrate high optical quantum efficiency (90%) resonant-cavity-enhanced mid-infrared photodetectors fabricated monolithically on a silicon platform. High quality photoconductive polycrystalline PbTe film is thermally evaporated, oxygen-sensitized at room temperature and acts as the infrared absorber. The cavity-enhanced detector operates in the critical coupling regime and shows a peak responsivity of 100 V/W at the resonant wavelength of 3.5 microm, 13.4 times higher compared to blanket PbTe film of the same thickness. Detectivity as high as 0.72 x 10(9) cmHz(1/2)W(-1) has been measured, comparable with commercial polycrystalline mid-infrared photodetectors. As low temperature processing (< 160 degrees C) is implemented in the entire fabrication process, our detector is promising for monolithic integration with Si readout integrated circuits.
A symmetric organic-based nonaqueous redox flow battery and its state of charge diagnostics by FTIR (2016)

A new nonaqueous symmetric redox flow battery was developed based on an organic ambipolar electroactive material. FTIR demonstrated great potential for online monitoring of the state of charge of this flow battery.
Five-year longitudinal changes in quantitative spinal cord MRI in multiple sclerosis (2020)

In MS, certain quantitative SC-MRI indices change over 5 years, reflecting ongoing tissue changes. Subject-specific trajectories of SC-MRI index change at 2 and 5 years are strongly correlated and highly relevant to follow-up disability. These findings suggest that individual dynamics of change should be accounted for when interpreting longitudinal SC-MRI measures and that measuring short-term change is predictive of long-term clinical disability.
P3‐413: Altered MicroRNA expression in Alzheimer blood mononuclear cells (2008)

The etiology of sporadic Alzheimer disease (AD) is multifactorial, and carriers of the apolipoprotein E ϵ4 (APOEϵ4) allele are at increased risk for developing this condition. AD is characterized by a systemic decline in various coding genes and proteins within multiple functional categories. By degrading transcripts or inhibiting translation, we hypothesized that non-coding microRNAs (miRNA) may play a role in this condition. Over 500 miRNAs, that have yet to be functionally characterized, have predicted target sites mostly in the 3' untranslated region of the mRNA of many genes. As a paradigm for the study of systemic molecular alterations, we analyzed the expression of miRNAs in blood mononuclear cells (BMC) and correlated their predicted targets with microarray profiling data of BMC in sporadic AD (Gene Regulation and Systems Biology, 2007:1; 263–274). Thirty-two AD and normal elderly controls (NEC) subjects were matched for ethnicity, age, gender and education. Various miRNAs were found to be significantly up-regulated (but none down-regulated) in Alzheimer BMC, and patterns of miRNA expression in AD patients may be contingent on the presence or absence of the APOEϵ4 allele. Down-regulated genes that are targeted by the up-regulated miRNAs were largely represented in the functional categories of Transcription/Translation and Synaptic Activity. Genes with multiple targeting miRNAs were within the functional category of Injury response/Redox homeostasis. Up-regulated miRNA miR-181b and -200a shared common targets in functional categories of Cell Cycle and DNA damage. Interestingly, miR-181b, which exhibited the greatest fold-increase expression in Alzheimer BMC, targeted the highest proportion of down-regulated genes in AD BMC (31.1 %), followed by miR-34a (21.7 %). The miRNA expression signatures exhibited good disease classification as judged by hierarchical clustering, and individual miRNAs may provide surrogate markers for AD progression. The current observations further support our model linking the development of AD pathology to systemic dysfunction in the cellular stress/antioxidant response and genomic maintenance.
The Biological and Medical Revolution by 2050 (2017)

Rather than attempting the impossible task of predicting the future, Professor Yves Levy, Chairman and Chief Executive Officer of the French National Institute of Health and Medical Research (Inserm) discussed, during his presentation as part of the cycle of conferences of the Sciences Po Health Chair 2016, the healthcare challenges we will face in the next thirty years. Report.
Edge detection with meta‐lens: from one dimension to three dimensions (2021)

Abstract Meta‐lens has successfully been developed for a variety of optical functions. We demonstrate a light‐field edge detection imaging system with a gallium nitride achromatic meta‐lens array. It enables edge detection from one dimension to three dimensions. The designed meta‐lens array consists of 60 by 60 achromatic meta‐lenses, which operate in the visible range from 400 to 660 nm. All of the light field information of objects in the scene can be captured and computed. The focused edge images from one dimension to three dimensions are extracted with depth estimation by image rendering. Three dimensions edge detection is two dimensions edge imaging with depth information. The focused edge images can be obtained by the sub‐image reconstruction of the light field image. Our multidimensional edge detection system by achromatic meta‐lens array brings novel advantages, such as broadband detection, data volume reduction, and device miniaturization capacity. Results of our experiments show new insight into applications of biological diagnose and robotic vision.
Quantification of alkylresorcinols in human plasma by liquid chromatography/tandem mass spectrometry (2010)

Alkylresorcinols (AR) are of interest as biomarkers of wholegrain wheat and rye intake in epidemiological studies and are currently mainly measured by gas chromatography/mass spectrometry (GC/MS) after labour-intensive sample preparation including liquid-liquid extraction, solid-phase extraction (SPE) and chemical derivatization. This manuscript describes and validates an alternative approach based on normal-phase liquid chromatography/tandem mass spectrometry for the quantification of alkylresorcinols in human plasma. The method requires neither SPE nor chemical derivatization and has a shortened run time compared to GC/MS. Normal- and reversed-phase columns and various mobile phases were evaluated with and without previous SPE of the samples. Normal-phase chromatography allowed separation of AR from the interfering triacylglycerols, diacylglycerols and sterols and enabled detection of AR even without SPE of the samples. The described method has instrumental lower limits of detection in the 25-75 pg range, and lower limits of quantification in the 75-250 pg range. Pooled human plasma and (2)H(4)-nonadecylresorcinol (internal standard) was applied to calibrate the method in the 20-12 000 nM range. The overall method showed intra-batch precision of 8.6% and an averaged accuracy of 100.2%. Applications for diverse human plasma samples are presented and are compared with the results determined by GC/MS. Based on the presented data; this method requiring less sample preparation is suggested for further evaluation as an alternative to GC/MS for analysis of biomarkers of wholegrain wheat and rye intake in epidemiological studies.
Petabit-Scale Silicon Photonic Interconnects With Integrated Kerr Frequency Combs (2022)

Silicon photonics holds significant promise in revolutionizing optical interconnects in data centers and high performance computers to enable scaling into the Pb/s package escape bandwidth regime while consuming orders of magnitude less energy per bit than current solutions. In this work, we review recent progress in silicon photonic interconnects leveraging chip-scale Kerr frequency comb sources and provide a comprehensive overview of massively scalable silicon photonic systems capable of capitalizing on the large number of wavelengths provided by such combs. We first consider the high-level architectural constraints and then proceed to detail the corresponding fundamental device designs supported by both simulated and experimental results. Furthermore, the majority of experimentally measured devices were fabricated in a commercial 300 mm foundry, showing a clear path to volume manufacturing. Finally, we present various system-level experiments which illustrate successful proof-of-principle operation, including flip-chip integration with a co-designed CMOS application-specific integrated circuit (ASIC) to realize a complete Kerr comb-driven electronic-photonic engine. These results provide a viable and appealing path towards future co-packaged silicon photonic interconnects with aggregate per-fiber bandwidth above 1 Tb/s, energy consumption below 1 pJ/bit, and areal bandwidth density greater than 5 Tb/s/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Development of new markers for hypoxic cells:131I]Iodomisonidazole and [131I]Iodoerythronitroimidazole (1996)

This study was aimed at developing ligands to evaluate tumor hypoxia by planar scintigraphy. Two 2-nitroimidazole analogues were developed as precursor compounds to image hypoxic tumors. Both tosylmisonidazole (Ts MISO) and tosylerythronitroimidazole (Ts ETNIM) were labeled with 131I. The biodistribution and autoradiographic evaluations by planar scintigraphy of 131I-IMISO and 131I-IETNIM were conducted at 1, 2 and 4 hours after administration to rats bearing 13762 breast tumors. Biodistribution of 131I-IMISO was also evaluated in Madison lung tumor-bearing mice. Intratumoral oxygen tension was measured by the Eppendorf system. Biodistribution showed similar tumor/blood and tumor/muscle count density ratios for both compounds. The thyroid uptake of both analogues was increased with time, suggesting in vivo deiodination probably occurred. Autoradiographs of 131I-IMISO and 131I-IETNIM revealed good visualization of the neoplasms. The tumor oxygen tension was 3-6 mmHg as compared to the normal tissue oxygenation of 30-40 mmHg. The findings indicate that these analogues can localize in the hypoxic region of solid tumors and may assist with quantitation of the hypoxic fraction of tumor for proper selection and evaluation of appropriate radiotherapy and chemotherapy.
V<inf>SET/RESET</inf> and V<inf>PGM</inf> generator without boosting dead time for 3D-ReRAM and NAND flash hybrid solid-state drives (2012)

A single-inductor, dual-output, parallel-boosting (SIDOPB) boost converter which simultaneously outputs 3V for ReRAM program V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">SET/RESET</sub> , 20V for NAND flash program V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">PGM</sub> , is proposed for a hybrid ReRAM and NAND flash 3D-integrated solid-state drive (SSD). Simultaneous boosting of two programming voltages is experimentally demonstrated without boosting dead time for the first time. Interference between ReRAM and NAND boosters is suppressed by the inductor design. There is no additional power increase or the performance degradation compared with the conventional boost converter using double-coil SSD. The area is reduced by 15%.