gebhart/patrepeval huggingface dataset:
Reduction of nicotinamide adenine dinucleotide levels by ultimate carcinogens in human lymphocytes. (1980)

The effect of several classes of DNA-damaging chemicals and closely related compounds on cellular nicotinamide adenine dinucleotide (NAD) levels was studied in freshly isolated peripheral human lymphocytes. Of the 21 compounds examined, 7 were direct DNA-damaging agents and 14 were non-DNA-damaging compounds or required metabolic activation to casue DNA damage. Rapid lowering of cellular NAD levels was caused by each of the direct DNA-damaging chemicals examined in this study including N-methyl-N'-nitr-N-nitrosoguanidine, methyl methanesulfonate, N-acetoxy-2-acetylaminofluorene, 7-bromomethylbenz(a)anthracene, and the benzo(a)pyrene derivatives, r-7,t-8-dihydroxy-9, 10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene and benzo(a)pyrene-4,5-epoxide. The indirect-acting carcinogen 2-acetylaminofluorene, 13 polycyclic aromatic hydrocarbons, and derivatives that were non-DNA-damaging did not cause lowering of NAD. The results suggest a general correlation between DNA damage and acute lowering of cellular NAD pools.
Constrained Multiobjective Optimization of a Common-Mode Suppression Filter (2012)

Designing an optimized common-mode suppression filter for a bend in a differential trace pair on a printed circuit board involves determining the geometrical parameters that simultaneously provide a large reduction of conversion noise, a small differential mode reflection coefficient and low overall loss, given hardware and manufacturing constraints. Therefore, a novel constrained multiobjective optimization technique is proposed that relies on intermediate surrogate models of the different cost functions instead of numerically expensive full-wave simulations, saving CPU time and memory resources. As a result, a 3-D Pareto-front is created and then constrained based on hardware limitations, depicting the tradeoff between the costs and allowing an easy selection of the most optimal layout geometry.
1.5kW linear polarized on PM fiber and 2kW on non-PM fiber narrow linewidth CW diffraction-limited fiber amplifier (2017)

We report on a ruggedized compact modular package narrow linewidth fiber amplifiers with 1.5kW linear polarized output in an all-PM fiber configuration and 2 kW in non-PM fiber configuration for various scientific and advanced applications. The fiber amplifiers have 2m output cable with connector termination for 15GHz linewidth and 20GHz linewidth in PM and in non-PM fiber configuration respectively. The fiber amplifiers have 40% wall-plug efficiency and 15nm spectral bandwidth for 1064nm wavelength range. Measured M<sup>2</sup> values of the output beam of the amplifiers are &lt; 1.1.
Distinct and shared genetic architectures of Gestational diabetes mellitus and Type 2 Diabetes Mellitus (2023)

Gestational diabetes mellitus (GDM) affects more than 16 million pregnancies annually worldwide and is related to an increased lifetime risk of Type 2 diabetes (T2D). The diseases are hypothesized to share a genetic predisposition, but there are few GWAS studies of GDM and none of them is sufficiently powered to assess whether any variants or biological pathways are specific to GDM. We conducted the largest genome-wide association study of GDM to date in 12,332 cases and 131,109 parous female controls in the FinnGen Study and identified 13 GDM-associated loci including 8 novel loci. Genetic features distinct from T2D were identified both at the locus and genomic scale. Our results suggest that the genetics of GDM risk falls into two distinct categories - one part conventional T2D polygenic risk and one part predominantly influencing mechanisms disrupted in pregnancy. Loci with GDM-predominant effects map to genes related to islet cells, central glucose homeostasis, steroidogenesis, and placental expression. These results pave the way for an improved biological understanding of GDM pathophysiology and its role in the development and course of T2D.
Fecal Lactoferrin (fLac) and Calprotectin (fCal) as Surrogate Markers of Mucosal Healing: Post-hoc Analysis from the PURSUIT SC Induction Study (2015)

Introduction: Previously we reported greater improvement in both fLac&fCal levels in UC pts who showed clinical response&endoscopic healing in PURSUIT SC induction golimumab(GLM)study1. These post-hoc analyses assessed association of fecal inflammatory markers, fLac&fCal, with Mayo endoscopy subscores using data from this study. Methods: The Ph3 portion of PURSUIT-SC was a multicenter, rand, PBO-controlled dble-blind study to evaluate safety&efficacy of induction therapy with SC GLM. Pts with Mayo scores of 6-12 inclusive, including endoscopic subscore >2 were rand to PBO/PBO, GLM 200mg/100mg, or GLM 400mg/ 200mg at Wks 0&2. Mucosal healing was assessed at Wk6 using Mayo endoscopy subscore. Stool samples were collected for fLac& fCal Wk0 thru Wk6. Assays for fLac&fCal concentrations were performed using validated methods. The area under a ROC curve(AUC)assessed the association of baseline&Wk6 fLac&fCal with Mayo endoscopy subscores of 0(defining normal or inactive disease)& subscores of 0 or 1(defining endoscopic healing in this study)at Wk6. Various cut offs of fLac&fCal concentrations were explored to determine balance of sensitivity&specificity for endoscopy subscores of 0 or 0 or 1. Results: Mayo endoscopy subscores of 0 or 1 were associated with lowest concentrations of fLac&fCal(Table). Baseline fLac&fCal were poor predictors for endoscopic healing at Wk6(AUCs< 0.63). Area under ROC curve analysis showed fLac&fCal at Wk6 are fair surrogate markers for normal/inactive endoscopic disease activity(endoscopy subscore of 0)at Wk6 with AUCs of 0.77&0.79, resp. Similar AUCs were observed for endoscopy subscores of 0 or 1. Cutoffs of fLac < 50 μg/ml & fCal < 250mg/kg at Wk6 offered reasonable sensitivity&specificity(fLac 0.74, 0.67 & fCal 0.79, 0.70)for normal/inactive endoscopic disease activity at Wk6. In contrast, cutoffs of fLac < 100μg/ml & fCal < 500mg/kg at Wk6 offered similarly reasonable sensitivity&specificity(fLac 0.73, 0.63 & fCal 0.74, 0.64)for endoscopy subscores of 0 or 1. Conclusion: At Wk6, Mayo endoscopy subscores were positively associated with levels of fLac&fCal. Cut-offs of fLac < 50μg/ml & fCal < 250mg/kg at Wk6 showed reasonable sensitivity&specificity for normal/endoscopic disease activity. Overall these data suggest that fecal inflammatory marker levels might be useful surrogates for endoscopic improvement.Table 1: Fecal Inflammatory Marker Concentrations and Mayo Endoscopy Subscores at Week 6
Problématique du stockage d'énergie situé chez le consommateur connecté au réseau (2003)

National audience
Abstract 306: Sympathetic Reinnervation is Required for Mammalian Cardiac Regeneration. (2015)

Rationale: Established animal models of limb and tissue regeneration with re-vascularization demonstrate a critical dependence on concurrent reinnervation by the peripheral nervous system. Objective: Considering the significant abundance of autonomic nerves in the mammalian heart we tested the hypothesis that reinnervation is required for neonatal mouse cardiac regeneration. Methods and Results: Crossing Wnt1:cre transgenic mice with a double-tandem (td) tomato reporter strain identifies all neural crest-derived cell lineages including the peripheral autonomic nerves in the heart. Whole mount epi-fluorescence microscopy facilitated the clear resolution of subepicardial autonomic nerves in the mouse ventricles providing unprecedented detail of the subepicardial neuroanatomy of the mouse heart. Sympathetic nerve bundles envelop the entire heart and extend to the tip of the ventricular apex. Our data demonstrate that during regeneration of the resected ventricular apex of the neonatal mouse heart, sympathetic nerves fibers undergo concurrent re-growth into the injury site resulting in complete sympathetic reinnervation of the regenerated tissue. Sympathectomy of the heart, induced by administration of 6-OHDA, was sufficient to block innate cardiac regeneration in the neonatal mouse. Conclusions: We report that the innate ability of the neonatal mouse heart to undergo regeneration in response to injury is dependent on sympathetic innervation of the ventricular myocardium. Ablation of post-ganglionic sympathetic nerves blocks the innate regenerative capacity of neonatal mouse hearts suggesting that sympathetic reinnervation is critical for ventricular regeneration. This finding has significant implications for adult regeneration following myocardial infarction where nerve growth is hindered by age related influences and scar tissue.
Immunoproteasomes shape the transcriptome and regulate the function of dendritic cells (IRM7P.476) (2014)

Abstract Background: By regulating protein degradation, constitutive proteasomes (CPs) regulate practically all fundamental cellular processes. Vertebrates also express immunoproteasomes (IPs), but the only well-established non-redundant role for IPs is their enhanced ability to generate peptides for MHC-I presentation. Results: Here we show that IPs regulate the expression of 8,104 genes in maturing bone marrow-derived dendritic cells (DCs). IPs regulated transcription of many mRNAs and maturation of a subset of them. These genes were separated into 15 different kinetic patterns, and Gene-Ontology analysis revealed enrichment linked to immune functions and housekeeping cellular processes, highlighting the complexity of the transcriptional cascade regulated by IPs. Notably, IPs’ impact on transcription was mediated through the non-redundant regulation of critical immune-related pathways, such as Nf-kB, STATs and IRFs. Furthermore, even when loaded with optimal amounts of SIINFEKL, IP-deficient DCs were inefficient for in vivo priming of OT-1 T cells. Conclusion: Our study shows that the role of IPs is not limited to antigen processing and highlights a new and critical role for IPs in regulation of gene expression. The dramatic impact of IPs on the transcriptional landscape could explain the various immune and non-immune phenotypes observed in vertebrates with IP-deficiency or -mutation.
Realization of IPMSM drive systems without both an electrolytic capacitor and an line inductor (2014)

This paper proposes a control method to realize interior permanent magnet synchronous motor (IPMSM) drive system without using both an electrolytic capacitor and an line inductor. In general, an electrolytic capacitor-less inverter shows input current vibration in the source side if there is a line impedance on the source. This vibration is caused by resonance with the line impedance and the DC-link capacitor. The current vibration causes current distortion and lowers the power factor. In general, the input current vibration has high frequency components because of low line impedance values. Thus, in order to reduce the input current vibration using the conventional dumping feedback control, it is necessary to lower the frequency by adding an inductor to the line impedance. In this paper, the authors propose a method that adds a cancellation voltage pulse to the three-phase voltage reference of the inverter, in order to prevent input current vibration. The simulation and experimental results confirm that the proposed method reduces the input current vibration effectively. The maximum power factor obtained by using the proposed method is 98.09 % and THD is 17.95 %.
Guest editors' introduction: Pervasive Retail (2011)

The retail experience is undergoing significant changes due to a confluence of pervasive computing technologies, such as affordable smartphones with a plethora of retail applications, social media, sensing and analytics, and wireless technologies. This issue contains three articles that examine some of the opportunities and challenges in the pervasive retail space.
PhI(OAc)2-Mediated Regioselective Synthesis of 5-Guanidino-1,2,4-thiadiazoles and 1,2,4-Triazolo[1,5-a]pyridines via Oxidative N–S and N–N Bond Formation (2019)

An effective and expeditious approach for the construction of biologically important 5-guanidino-1,2,4-thiadiazole and 1,2,4-triazolo[1,5-a]pyridine derivatives has been developed. This new protocol involves the phenyliodine(III) diacetate [PhI(OAc)2]-mediated oxidative cyclization of thioureas/2-aminopyridines and imidates via N–S and N–N bond formation at ambient temperature. This method furnishes the versatile 5-guanidino-1,2,4-thiadiazoles and 1,2,4-triazolo[1,5-a]pyridines in a scalable manner with high efficiency and excellent regioselectivity.
Charge transport in a fluid with electrostatic cross-field modulation (1985)

The physics of charge transport by a fluid flowing in a channel subject to electrostatic cross-field modulation is analyzed as a two-dimensional time-transient problem. The coupled non-linear system of equations is comprised of the Poisson and current continuity equations. The fluid flow is assumed to be decoupled from the electrostatics and a simple potential flow model is currently used. A numerical procedure is described for the solution of the non-dimensionalized equations. The procedure computes electrostatic potential and field using the boundary element method (BEM), and charge density using the method of characteristics. Time transient results for turn-on and shut-off of the ion stream are discussed.
Molecular cloning and localization of human ataxin2-like gene (1998)

Through the analysis of EST (Expressed Sequence Tag) database, 25 human ESTs with significant similarity to human atrophin-1 gene, which is responsible for dentatorubral pallidoluysian atrophy (DRPLA) , were assembled into 5 contigs. Based upon three of these contigs, three probes were designed to screen the human cDNA libraries and gcnomic DNA libraries. Sequences of the cDNA clones obtained from heart and testis cDNA libraries were assembled inio a 4.6 kb cDNA sequence (termed atrophin-1 like gene, ATN1L) which contained a complete open reading frame putalively encoded 1012 amino acids. The coding region is composed of 9 exons. Both cDNA and deduced protein sequence share striking similarity with human atrophin-1 and rat atrophin-1-related gene and protein. Comparative analysis also indicated that C-terminus of the protein was more conservative than its N-terminus. It was a strongly hydrophilic protein with two regions of alternating acidic and basic amino acid residues as the human atrophin-1 and rai atrophin-1 related protein were. We further mapped this gene to chromosome 1p36 by fluorescence in situ hybridization.
Supplementary Data from Tumor necrosis factor deficiency inhibits mammary tumorigenesis and a tumor necrosis factor neutralizing antibody decreases mammary tumor growth in neu/erbB2 transgenic mice (2023)

Supplementary Data from Tumor necrosis factor deficiency inhibits mammary tumorigenesis and a tumor necrosis factor neutralizing antibody decreases mammary tumor growth in neu/erbB2 transgenic mice
Hybrid Thermo-Responsive Polymer Systems and Their Biomedical Applications (2020)

Targeted and controlled drug delivery employing "smart materials" is a widely investigated field, within which stimuli-responsive polymers, particularly those which are thermo-responsive, have received considerable attention. Thermo-responsive polymers have facilitated the formulation of insitu gel forming systems which undergo a sol-gel transition at physiological body temperature, and have revolutionised the fields of tissue engineering, cell encapsulation, and controlled, sustained delivery of both drugs and genes. However, the use of single thermo-responsive polymers in the creation of these systems has posed numerous problems in terms of physico-mechanical properties. Hybridisation of these thermo-responsive polymers has therefore been employed, resulting in the creation of tailor-made drug delivery systems with optimal gelation temperatures and concentrations, ideal viscosities and improved gel strengths. This article reviews various thermo-responsive polymers that have been employed in the formulation of thermo-gelling systems. Special attention has been given to the hybridisation of each of these polymers, the resulting systems that have been created, and their biomedical applications.
Insulin Therapy for Diabetes (2013)

Diabetes affects 25.8 million people, or 8.3% of the U.S. population. Among people with diabetes, 26% are insulin users.[1] Therapy with insulin is effective at lowering blood glucose in patients with diabetes. Insulin is a key player in the control of diabetes for patients with type 1, and it is required at later stages by patients with type 2. Hyperglycemia in type 1 diabetes is a result of the deficiency of insulin, and in type 2 diabetes hyperglycemia is due to impaired tissue response to insulin.
A signal estimation approach to functional MRI (2001)

In the last half decade, fast methods of magnetic resonance imaging have led to the possibility, for the first time, of non-invasive dynamic brain imaging. This has led to an explosion of work in the Neurosciences. From a signal processing viewpoint the problems are those of nonlinear spatio-temporal system identification. In this paper, we develop new methods of identification using novel spatial regularization. We also develop a new model comparison technique and use that to compare our method with existing techniques on some experimental data.
Analysis of rotor shell losses in a magnetically levitated homopolar hollow-shaft permanent magnet synchronous motor (2012)

This paper analyzes challenges that arise when the rotational speed in magnetically levitated hollow-shaft PMSMs is increased. Going to higher speeds highlights the advantages of such machines as being contact and contamination free, but leads to considerably higher losses. We propose a model and supply experimental data and simulations to subdivide losses into different categories with regard to specific optimizations. We particularly focus on the high rotor shell eddy current losses specific for this machine.
2&#x00D7;21 Gbps symmetrical full-duplex transmission of OFDM wireless signals over a bidirectional IMDD Radio-over-Fiber system at 60 GHz (2010)

A full-duplex bidirectional 60 GHz RoF system for in-building wireless applications employing DSB IMDD techniques is experimentally demonstrated. Symmetrical 2×21 Gbps transmission over 500-m standard single mode fiber and 2.5-m wireless distance is successfully achieved.
An array-based melt curve analysis method for the identification and classification of closely related pathogen strains (2018)

PCR-based techniques are widely used to identify disease causing bacterial and viral pathogens, especially in point-of-care or near-patient clinical settings that require rapid results and sample-to-answer workflows. However, such techniques often fail to differentiate between closely related species that have highly variable genomes. Here, a homogenous (closed-tube) pathogen identification and classification method is described that combines PCR amplification, array-based amplicon sequence verification, and real-time detection using an inverse fluorescence fluorescence-resonance energy transfer technique. The amplification is designed to satisfy the inclusivity criteria and create ssDNA amplicons, bearing a nonradiating quencher moiety at the 5'-terminus, for all the related species. The array includes fluorescent-labeled probes which preferentially capture the variants of the amplicons and classify them through solid-phase thermal denaturing (melt curve) analysis. Systematic primer and probe design algorithms and empirical validation methods are presented and successfully applied to the challenging example of identification of, and differentiation between, closely related human rhinovirus and human enterovirus strains.
Honeycomb-Structured Multi-Crystalline Silicon Solar Cells With 18.6% Efficiency Via Industrially Applicable Laser Process (2008)

In this paper, we present a novel process for fabricating a hemi-spherical shape for texture structure, namely known as honeycomb structure texture, for large area multi-crystalline silicon (mc-Si) solar cells. The method is composed of laser-patterning of mask film and wet chemical etching of wafer beneath the mask film through the pattern, substituting lithographic process usually used for fabricating such structure in small scale. After the texturization process, solar cells were made by utilizing conventional fabrication equipments, i.e. phosphorus diffusion in tube furnace, anti-reflection coating by chemical vapor deposition, front and rear electrodes formation by screen printing, and contact formation by furnace. The well-controlled texture with an optimized massproduction process for fabricating high-efficiency cell contributed to improving the conversion efficiency. As the result, 18.6% in conversion efficiency was achieved with mc-Si wafer in industrial size of 15 cm x 15 cm, independently confirmed by National Institute of Advanced Industrial Science and Technology (AIST). The main fabrication processes of the development described for the cell was as follows; 1) novel texturization method by combination of laser-patterning and wet chemical etching, 2) optimization of screen printing, metallization process of firing profile condition, and emitter diffusion.
ESR EVIDENCE OF AN ELECTRON TRANSFER BETWEEN ARYLPHOSPHINES AND ARYLNITROSO COMPOUNDS (1977)

Abstract Electron transfer between arylphosphines and arylnitroso compounds gives rise to the formation of free radicals which have been characterized by esr
Anticipating human actions for collaboration in the presence of task and sensor uncertainty (2014)

A representation for structured activities is developed that allows a robot to probabilistically infer which task actions a human is currently performing and to predict which future actions will be executed and when they will occur. The goal is to enable a robot to anticipate collaborative actions in the presence of uncertain sensing and task ambiguity. The system can represent multi-path tasks where the task variations may contain partially ordered actions or even optional actions that may be skipped altogether. The task is represented by an AND-OR tree structure from which a probabilistic graphical model is constructed. Inference methods for that model are derived that support a planning and execution system for the robot which attempts to minimize a cost function based upon expected human idle time. We demonstrate the theory in both simulation and actual human-robot performance of a two-way-branch assembly task. In particular we show that the inference model can robustly anticipate the actions of the human even in the presence of unreliable or noisy detections because of its integration of all its sensing information along with knowledge of task structure.
ISOTOPE SHIFT MEASUREMENTS OF HELIUM (1991)

The helium isotope shift provides invaluable information for testing theories describing many-body systems. We review the recent advances in measurements of the isotope shifts for helium with an emphasis on a new experimental technique.