gebhart/patrepeval huggingface dataset:
On the Throughput Maximization in Dencentralized Wireless Networks (2008)

A distributed single-hop wireless network with $K$ links is considered, where the links are partitioned into a fixed number ($M$) of clusters each operating in a subchannel with bandwidth $\frac{W}{M}$. The subchannels are assumed to be orthogonal to each other. A general shadow-fading model, described by parameters $(α,\varpi)$, is considered where $α$ denotes the probability of shadowing and $\varpi$ ($\varpi \leq 1$) represents the average cross-link gains. The main goal of this paper is to find the maximum network throughput in the asymptotic regime of $K \to \infty$, which is achieved by: i) proposing a distributed and non-iterative power allocation strategy, where the objective of each user is to maximize its best estimate (based on its local information, i.e., direct channel gain) of the average network throughput, and ii) choosing the optimum value for $M$. In the first part of the paper, the network hroughput is defined as the \textit{average sum-rate} of the network, which is shown to scale as $Θ(\log K)$. Moreover, it is proved that in the strong interference scenario, the optimum power allocation strategy for each user is a threshold-based on-off scheme. In the second part, the network throughput is defined as the \textit{guaranteed sum-rate}, when the outage probability approaches zero. In this scenario, it is demonstrated that the on-off power allocation scheme maximizes the throughput, which scales as $\frac{W}{α\varpi} \log K$. Moreover, the optimum spectrum sharing for maximizing the average sum-rate and the guaranteed sum-rate is achieved at M=1.
FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts (2006)

Human diploid fibroblasts (HDF) immortalized by hTERT and simian virus 40 (SV40) early region (ER) exhibit a limited degree of transformation upon the expression of activated H-RAS (H-RAS V12) compared with rat embryonic fibroblasts (REF) immortalized by SV40 ER. Here, we identified FRA1 as a determinant for this difference in RAS-induced transformation. FRA1 was not induced by H-RAS V12 in the immortalized HDF, in contrast to its marked accumulation in the immortalized REF. Ectopic expression of FRA1 significantly enhanced anchorage-independent growth of various HDF expressing hTERT, SV40 ER, and H-RAS V12. More importantly, FRA1 could induce anchorage-independent growth as well as nude mice tumor formation of the immortalized HDF in the absence of H-RAS V12. The results of an in vitro kinase assay clearly showed that the RAS-induced extracellular signal-regulated kinase (ERK) activation, which is responsible for FRA1 induction, was markedly attenuated in the HDF compared with that in the REF, despite no obvious differences in the phosphorylation status of ERK between the species. Our results strongly suggest that HDF negatively regulate the mitogen-activated protein kinase kinase (MEK)/ERK pathway more efficiently than REF, and consequently express less malignant phenotypes in response to H-RAS V12.
Proceedings of the 2017 International Conference on Embedded Wireless Systems and Networks (2017)

The International Conference on Embedded Wireless Systems and Networks (EWSN 2017) is a highly selective single-track international conference focussing on premier research results at the intersection of embedded systems and wireless networking –an area of highest relevance for visionary technologies such as the Internet of Things or Cyber-Physical Systems and application domains such as Smart Production, Smart Cities, or Connected Cars. The featured topic of the 2017 edition of EWSN is “Dependability” and we specifically welcome contributions that aim at making networked embedded systems more reliable, predictable, safe, and secure in order to enable critical applications that require guaranteed performance.
In situ Cryo-FIB/SEM imaging of frost formation and ice-substrate interface on superhydrophobic surfaces (2012)

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.
Molecular and pharmacological strategies to overcome multidrug resistance (2001)

Multidrug resistance is a major obstacle to the effective treatment of cancer. Despite vast improvements in our understanding of the mechanisms of drug resistance, relatively few significant advances have been made towards effectively circumventing it in a clinical setting. The ability to modulate multidrug resistance has been complicated by the fact that many human tumors simultaneously exhibit multiple resistance mechanisms. In order to effectively overcome multidrug resistance it will be necessary to design new strategies that combine multiple modulating agents and approaches. This review provides an overview of the major causes of multidrug resistance and summarizes many of the current approaches being taken to overcome it. We also describe how liposomal drug delivery systems can be utilized to aid in achieving these goals.
Development of an Exponential Sampling Correlator with Lagged Fibonacci Series for Polydisperse Nanoparticles (2007)

Correlator of a photon correlation spectroscopy (PCS) apparatus for measuring nanoparticles with a polydisperse distribution has been developed with unique data sampling methods. In the present exponential sampling correlator, the sampling times are increased by various geometrical ratios, each of which relates the integral multiples of minimum sampling time to the individual channels. The geometrical progressions are able to transform the data into the lagged Fibonacci series. Simulation results show that the newly developed correlator has an improved performance over the conventional exponential sampling correlator because no rounding errors occur in the processing of the data.
Block public access: trust safety verification of access control policies (2020)

Data stored in cloud services is highly sensitive and so access to it is controlled via policies written in domain-specific languages (DSLs). The expressiveness of these DSLs provides users flexibility to cover a wide variety of uses cases, however, unintended misconfigurations can lead to potential security issues. We introduce Block Public Access, a tool that formally verifies policies to ensure that they only allow access to trusted principals, i.e. that they prohibit access to the general public. To this end, we formalize the notion of Trust Safety that formally characterizes whether or not a policy allows unconstrained (public) access. Next, we present a method to compile the policy down to a logical formula whose unsatisfiability can be (1) checked by SMT and (2) ensures Trust Safety. The constructs of the policy DSLs render unsatisfiability checking PSPACE-complete, which precludes verifying the millions of requests per second seen at cloud scale. Hence, we present an approach that leverages the structure of the policy DSL to compute a much smaller residual policy that corresponds only to untrusted accesses. Our approach allows Block Public Access to, in the common case, syntactically verify Trust Safety without having to query the SMT solver. We have implemented Block Public Access and present an evaluation showing how the above optimization yields a low-latency policy verifier that the S3 team at AWS has integrated into their authorization system, where it is currently in production, analyzing millions of policies everyday to ensure that client buckets do not grant unintended public access.
Non-Oral Poster 56 (2010)

OBJECTIVES: To compare the functional outcomes of bilateral sacrospinous hysteropexy after anterior colporrhaphy with anterior and apical augmentation using an acellular cadaveric dermal graft versus polypropylene mesh. MATERIALS AND METHODS: 40 women with Stage ≥2 prolapse who underwent sacrospinous hysteropexy and allograft augmented anterior colporrhaphy (Group I) were compared with 71 women who underwent a bilateral anterior sacrospinous hysteropexy and anterior colporrhaphy with polypropylene augmentation of the anterior compartment (Group II) and returned for follow-up examinations at median 16.6 and 12.5 months follow-up, respectively. The dermal allograft was secured using single permanent sutures placed 1.5 cm medial to the ischial spines on both the right and left sacrospinous ligament (SSL) and along the arcus tendineus fascia pelvis ATFP bilaterally. In Group II, the polypropylene mesh was approximated over the anterior colporrhaphy site distally and not anchored to the ATFP laterally. In both groups each SSL suture was secured to both the allograft and polypropylene mesh to a fixation point on the ipsilateral vaginal apex located 1 cm lateral to the cervix on both sides simultaneously suspending the vaginal apices in both groups. Midurethral sling procedures and posterior colporrhaphy were performed if indicated. Women reported on dyspareunia on Likert scales and completed the Pelvic Floor Distress Inventory short form (PFDI-20) as well as the Pelvic Organ Prolapse/ Urinary Incontinence Sexual Questionnaire (PISQ-12) before and after surgery. Change in PISQ-12 total scores and individual scores was assessed using signed rank test. McNemar's test was used to assess dyspareunia Likert scales pre and postoperatively. RESULTS: Mean age (56.2, 57.8), BMI (27.8, 25.8), and median parity (3, 3) were similar between groups. There were no graft erosions in the allograft group. There were 10 (14%) erosions in women who underwent polypropylene mesh augmentation. Group I had higher a higher posterior repair rate than group II (95% vs. 78.9%, P = 0.024). There was no difference in the rate of urethrolysis between women who had hysteropexy with allograft augmented anterior colporrhaphy (Group I) versus those with polypropylene mesh repair (Group II). Postoperatively, 7/34 (20.6%) and 11/56 (19.6%) reported dyspareunia (P = 0.913) at a median follow of 12.3 and 11.7 months in Group I and II, respectively. De novo dyspareunia was reported in 19.2% and 14.3% of women in Group I and II respectively, P = 0.712. Total PISQ-12 scores significantly improved in both groups postoperatively (4.05 vs. 0.64, P < .005 for both), at 14.6 and 12.5 months follow-up, the improvement was not different between the two groups (P = 0.352). Postoperative PFDI scores significantly improved in both groups. Mean change between Groups I and II, was −35.6 versus −39.9, (P = 0.716), respectively. CONCLUSION: There was no difference in self-reported quality of life or sexual function in women who underwent hysteropexy with allograft versus polypropylene mesh augmented anterior colporrhaphy.
Quantum Optical Metrology of Correlated Phase and Loss (2020)

Optical absorption measurements characterize a wide variety of systems from atomic gases to in vivo diagnostics of living organisms. Here we study the potential of nonclassical techniques to reduce statistical noise below the shot-noise limit in absorption measurements with concomitant phase shifts imparted by a sample. We consider both cases where there is a known relationship between absorption and a phase shift, and where this relationship is unknown. For each case we derive the fundamental limit and provide a practical strategy to reduce statistical noise. Furthermore, we find an intuitive correspondence between measurements of absorption and of lossy phase shifts, which both show the same analytical form for precision enhancement for bright states. Our results demonstrate that nonclassical techniques can aid real-world tasks with present-day laboratory techniques.
New carbazole-based host material for low-voltage and highly efficient red phosphorescent organic light-emitting diodes (2012)

A new carbazole-based host material for red emitters, BBTC, was designed, synthesized and characterized with the phosphorescent organic light-emitting diodes (PHOLEDs). With the molecular design strategy of maintaining the large triplet energy and a good hole transporting ability of carbazole while increasing the morphological and electrochemical stability, the C3 and C6 positions of carbazole are blocked with biphenyl groups and the C9 position is terminated with a terphenyl group. Red PHOLEDs employing a conventional dopant material, bis(1-phenylisoquinoline)(acetylacetonate)iridium(III) ((piq)2Ir(acac)), in the emissive layer showed nearly 100% internal quantum efficiency (corresponding to the external quantum efficiency of 19.3%) with reduced efficiency roll-off. We attribute these results to the good electron–hole balance resulting from the good hole mobility of BBTC and low hole injection barrier from the hole transport layer to BBTC host in the emission layer. In addition, owing to its good hole transporting property, it can be utilized as a hole transport layer in organic light-emitting devices enabling low voltage operation of the devices.
Effects of intravesical administration of sensory neuron-specific receptor agonist on voiding function in rats with cyclophosphamide-induced cystitis. (2019)

The current results indicate that intravesical administration of a selective rat sensory neuron-specific receptor 1 agonist can inhibit the micturition reflex and can ameliorate cyclophosphamide-induced bladder overactivity in rats.
Influence of electronic properties on the threshold behaviour of organic laser diode structures (2006)

By employing a combined optical/electronic model, we investigate the effect of electronic properties on the performance of three layer organic semiconductor structures, which are a potential candidate for future electrically pumped organic laser diodes. The drift-diffusion equations which describe particle transport are coupled to the spatially inhomogeneous laser rate equations to solve for the dynamics of the excited state and photon population in the laser cavity. Due to the high current densities considered, high particle densities occur, which implies that annihilation processes between the different particle species have to be considered. On the optical side, we take into account the absorption of the metal electrodes required for current injection to obtain the intensity profiles of the guided modes. Our calculations show that the inclusion of annihilation processes leads to a strong dependence of the laser threshold on the charge carrier mobilities, in contrast to the situation when exciton annihilation is neglected. We observe optimum values for the charge carrier mobilities in the emission layer regarding the threshold current and power density. On the other hand, an increase of the mobilities in the transport layers leads to a reduction of these quantities. The threshold voltage decreases for increasing mobilities, regardless of the layer in which the mobility is increased. For optimised values, we obtain a threshold current density of j<sub>thr</sub> = 267 A/cm<sup>2</sup> with annihilation processes taken into account. The presented results can serve as guidelines in the search for material combinations and devices structures suitable for electrically pumped organic semiconductor laser diodes.
Photonic crystals: shaping the flow of thermal radiation (2011)

In this paper we explore theory, design, and fabrication of photonic crystal (PhC) based selective thermal emitters. In particular, we focus on tailoring spectral and spatial properties by means of resonant enhancement in PhC’s. Firstly, we explore narrow-band resonant thermal emission in photonic crystals exhibiting strong spectral and directional selectivity. We demonstrate two interesting designs based on resonant Q-matching: a vertical cavity enhanced resonant thermal emitter and 2D silicon PhC slab Fano-resonance based thermal emitter. Secondly, we examine the design of 2D tungsten PhC as a broad-band selective emitter. Indeed, based on the resonant cavity coupled resonant modes we demonstrate a highly selective, highly-spectrally efficient thermal emitter. We show that an emitter with a photonic cut-off anywhere from 1.8 μm to 2.5 μm can be designed.
Robustness of the Unscented K (2009)

The Unscented Kalman Filter (UKF) was applied to state and parameter estimation of a one degree of freedom robot link with an elastic, cable-driven transmission. Only motor encoder and command torque data were used as input to the filter. The UKF was used offline for joint state and model-parameter estimation, and online for state estimation. This paper presents an analysis of the robustness of the UKF to unknown/unmodeled variation in inertia, cable tension and contact forces, using experimental data collected with the robot.
Stretchable and Conformable Electronics: Heading Toward Market Reality (2017)

Stretchable and conformal electronics are more than just novelties. This article describes how many of the simpler and less glamorous aspects of stretchable and conformable devices have already been commercialized or are very close to being commercialized.
A New Access to C‐Arylglycosides Related to the Gilvocarcins. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin (2015)

New antibacterials are needed to tackle antibiotic-resistant bacteria. Type IIA topoisomerases (topo2As), the targets of fluoroquinolones, regulate DNA topology by creating transient double-strand DNA breaks. Here we report the first co-crystal structures of the antibacterial QPT-1 and the anticancer drug etoposide with Staphylococcus aureus DNA gyrase, showing binding at the same sites in the cleaved DNA as the fluoroquinolone moxifloxacin. Unlike moxifloxacin, QPT-1 and etoposide interact with conserved GyrB TOPRIM residues rationalizing why QPT-1 can overcome fluoroquinolone resistance. Our data show etoposide's antibacterial activity is due to DNA gyrase inhibition and suggests other anticancer agents act similarly. Analysis of multiple DNA gyrase co-crystal structures, including asymmetric cleavage complexes, led to a 'pair of swing-doors' hypothesis in which the movement of one DNA segment regulates cleavage and religation of the second DNA duplex. This mechanism can explain QPT-1's bacterial specificity. Structure-based strategies for developing topo2A antibacterials are suggested.
Milk Protein–Based Infant Formula Containing Rice Starch and Low Lactose Reduces Common Regurgitation in Healthy Term Infants: A Randomized, Blinded, and Prospective Trial (2014)

The rice starch prethickened lactose-free milk protein-based formula (rice) supported normal growth and safe use as the sole source of feeding for normal infants over the first 4 months of life. The rice formula was efficacious in providing a clinically relevant reduction of spit-up frequency in otherwise healthy term infants.
The FPGA High-Performance Computing Alliance Parallel Toolkit (2007)

We describe the FPGA HPC Alliance's parallel toolkit (PTK), an initial step towards the standardization of high-level configuration and APIs for high-performance reconfigurable computing (HPRC). We discuss the motivation and challenges of reaping the performance benefits of FPGAs for memory-bound HPC codes and describe the approach we have taken on the FHPCA supercomputer Maxwell.
Measurement of imaging properties of scintillating fiber optic plate (2014)

Scintillating Fiber Optic Plates (SFOP) or Fiber Optic Scintillator (FOS) made with scintillating fiber-glass, were investigated for x-ray imaging. Two different samples (T x W x L = 2cm x 5cm x 5cm) were used; Sample A: 10&mu;m fibers, Sample B: 50&mu;m fibers both with statistically randomized light absorbing fibers placed in the matrix. A customized holder was used to place the samples in close contact with photodiodes in an amorphous silicon flat panel detector (AS1000, Varian), typically used for portal imaging. The detector has a 392&mu;m pixel pitch and in the standard configuration uses a gadolinium oxy-sulphide (GOS) screen behind a copper plate. X-ray measurements were performed at 120kV (RQA 9 spectrum), 1MeV (5mm Al filtration) and 6MeV (Flattening Filter Free) for Sample A and the latter 2 spectra for Sample B. A machined edge was used for MTF measurements. The measurements showed the MTF degraded with increased X-ray energies because of the increase in Compton scattering. However, at the Nyquist frequency of 1.3lp/mm, the MTF is still high (FOS value vs. Cu+GOS): (a) 37% and 21% at 120kVp for the 10&mu;m FOS and the Cu+GOS arrays, (b) 31%, 20% and 20% at 1MeV and (c) 17%, 11% and 14% at 6MeV for the 10&mu;m FOS, 50&mu;m FOS and the Cu+GOS arrays. The DQE(0) value comparison were (a) at 120kV ~24% and ~13 % for the 10&mu;m FOS and the Cu+GOS arrays (b) at 1MV 10%, 10% and 7% and (c) at 6MV 12%, ~19% and 1.6% for the 10&mu;m FOS , 50&mu;m FOS and Cu+GOS arrays.
SYT‐SSX breakpoint peptide vaccines in patients with synovial sarcoma: A study from the Japanese Musculoskeletal Oncology Group (2012)

In the present study, we evaluated the safety and effectiveness of SYT-SSX-derived peptide vaccines in patients with advanced synovial sarcoma. A 9-mer peptide spanning the SYT-SSX fusion region (B peptide) and its HLA-A*2402 anchor substitute (K9I) were synthesized. In Protocols A1 and A2, vaccines with peptide alone were administered subcutaneously six times at 14-day intervals. The B peptide was used in Protocol A1, whereas the K9I peptide was used in Protocol A2. In Protocols B1 and B2, the peptide was mixed with incomplete Freund's adjuvant and then administered subcutaneously six times at 14-day intervals. In addition, interferon-α was injected subcutaneously on the same day and again 3 days after the vaccination. The B peptide and K9I peptide were used in Protocols B1 and B2, respectively. In total, 21 patients (12 men, nine women; mean age 43.6 years) were enrolled in the present study. Each patient had multiple metastatic lesions of the lung. Thirteen patients completed the six-injection vaccination schedule. One patient developed intracerebral hemorrhage after the second vaccination. Delayed-type hypersensitivity skin tests were negative in all patients. Nine patients showed a greater than twofold increase in the frequency of CTLs in tetramer analysis. Recognized disease progression occurred in all but one of the nine patients in Protocols A1 and A2. In contrast, half the 12 patients had stable disease during the vaccination period in Protocols B1 and B2. Of note, one patient showed transient shrinkage of a metastatic lesion. The response of the patients to the B protocols is encouraging and warrants further investigation.
Toward Microwave-to-Optical Conversion using Erbium Doped Crystals and Integrated Resonators (2019)

We present progress towards a bidirectional coherent microwave-to-optical photon converter using an ensemble of rare-earth ions coupled to integrated photonic and microwave resonators. © 2019 The Author(s)