gebhart/patrepeval huggingface dataset:
The Importance of Electrostatic Interactions in the Stereoselective 1,3-Dipolar Cycloadditions of Nitrones to Chiral Allyl Ethers: An Experimental and Force Field Approach (1998)

The 1,3-dipolar cycloaddition of formaldehyde N-benzylnitrone with β′-alkoxy- and γ-alkoxy-α,β-unsaturated esters was investigated. The stereochemical outcome of these reactions was nicely rationalized on the basis of an interpretation of the inside alkoxy theory emphasizing the electrostatic interactions in the reaction TS. The force field approach previously developed for evaluating the stereoselection in nitrile oxide cycloadditions to chiral alkenes was successfully extended to nitrones′ reactions.
Chemical modification of acrylamide gels: verification of the role of ionization in phase transitions (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical modification of acrylamide gels: verification of the role of ionization in phase transitionsDavid Nicoli, Carl Young, Toyoichi Tanaka, Alfred Pollak, and George WhitesidesCite this: Macromolecules 1983, 16, 6, 887–890Publication Date (Print):June 1, 1983Publication History Published online1 May 2002Published inissue 1 June 1983https://pubs.acs.org/doi/10.1021/ma00240a011https://doi.org/10.1021/ma00240a011research-articleACS PublicationsRequest reuse permissionsArticle Views209Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Aspects of Pump Wavelength Selection for Pr3+-doped Fiber Amplifiers (1994)

Due to the relatively small absorption cross section of the pump transition of Pr3+ (3H4 → 1G4) in ZBLAN, the success of praseodymium-doped fluoride fiber amplifiers (PDFFA) depends strongly on the availability of high power pump sources. So far, three pump wavelengths have been employed: 980, 1017 and 1047 nm. The pump source in the case of 1047 nm pumping is a diode-pumped Nd:YLF-laser. The high output power of this source leads to amplifier designs suited for practical applications [1]
Composites of plasma treated poly(etherimide) films with gold nanoparticles and lysine through layer by layer assembly: a “friendly-rough” surface for cell adhesion and proliferation for tissue engineering applications (2008)

A composite film fabricated by plasma treated poly(etherimide) with subsequent deposition of gold nanoparticles and lysine using layer by layer assembly has been demonstrated to be good for cell attachment and proliferation making it an attractive strategy for tissue engineering applications. As compared to the other methods the decrease in contact angle obtained here does not depend much on the plasma treatment thus affecting the polymer structure minimally. A combination of surface roughness provided by the gold nanoparticles and the presence of amine groups of lysine is hypothesized to be the reason for the features observed.
Specific Secondary Biological Properties of Purified Rabbit Immunoglobulin M and Immunoglobulin G Antibodies to Brucella abortus and Bordetella pertussis (1971)

Rabbit immunoglobulin (Ig)M and IgG antibodies to Brucella abortus and Bordetella pertussis were isolated as purified products and their specific secondary biological activities were compared. IgM antibodies were found to be more active than IgG proteins in inducing agglutination and sensitization of B. abortus for the complement-dependent bactericidal effect and in inhibiting B. pertussis-induced lymphocytosis in the mouse. IgM and IgG antibodies were found to be equally effective in inducing agglutination of B. pertussis suspended in a colloidal solution. These data parallel previous work to indicate that IgM antibodies to bacterial surface antigens are more efficient than IgG molecules in initiating biological processes concerned with the inactivation of these pathogens.
ChemInform Abstract: Studies on Selective Reductions of Rapamycin (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
H2O- and O3-Based Atomic Layer Deposition of High-K Dielectric Films on GeO2 Passivation Layers (2009)

Atomic layer deposition (ALD) is considered an enabling technique for the deposition of dielectrics on sensitive surfaces such as germanium. Proper control of the interfacial layer between Ge and the high-κ layer has been shown to be crucial for obtaining good performance of Ge-based metal-oxide-semiconductor devices. In this work, we compare O 3 - and H 2 O-based ALD of HfO 2 and Al 2 O 3, and report on the thickness and electrical quality of GeO 2 passivation layers. The thickness of the interfacial layer depends on the oxidant used and affects the interface state density. A small degree of intermixing at the GeO 2 /high-κ interface is observed for all ALD process conditions. The interface state density can be significantly reduced by annealing the Pt-gated capacitors in forming gas (H 2 /N 2 ) at 300°C. After annealing, the interface state density becomes almost independent of the thickness of the GeO 2 passivation layer.
Detailed Structure of Diamond-Type Lipid Cubic Nanoparticles (2006)

Supramolecular three-dimensional self-assembly of nonlamellar lipids with fragments of the protein immunoglobulin results in a bicontinuous cubic phase fragmented into nanoparticles with open water channels (cubosomes). The structure of the diamond-type cubic nanoparticles is characterized experimentally by freeze-fracture electron microscopy, and it is mathematically modeled with nodal surfaces emphasizing the fluid-like undulations of the cubosomic interfaces. Based on scaling-up and scaling-down approaches, we present stable and intermediate-kind nanoparticles resulting from the cubosomic growth. Our results reveal the smallest stable diamond-type cubosomic entity that can serve as a building block of more complex nanostructured fluid drug delivery vehicles of therapeutic proteins. The evidence presented for lipid-bilayer undulations in the surface region of the protein/lipid cubosomes could have important consequences for possible applications of these hierarchically organized porous nanoparticles.
Carrier Ethernet Architectures and Services (2012)

Ethernet is becoming a dominant technology in enterprise networks, allowing bandwidth partitioning, user segregation, and traffic prioritization, introduced by IEEE 802.1P and 1Q. Ethernet is scalable from 10 Mbps to 100 Gbps with finer granularity as low as 56 kbps and 1 Mbps. Carrier Ethernet allows incremental bandwidth assignment. Ethernet transport network is a two-layer network consisting of Ethernet MAC layer network and Ethernet PHY layer network. This chapter describes the interface between user and network, interface between networks, and connection types between users. UNI tunnel access (UTA) is composed of a UTA OVC component in the Operator MEN and an associated VUNI in Provider MEN and RUNI in the Operator MEN components. The chapter describes the requirements for each component. It defines the Metro Ethernet fundamentals in terms of architecture and services that can be used in service deployments on a single network as well as on multiple networks. Controlled Vocabulary Terms Channel allocation; ethernet networks; media access protocol; tunnels
Standard-Compliant Content Adaptation in IPTV Systems (2012)

IPTV, which is based on the universal IP infrastructure, has the inherent nature of heterogeneity in terms of content, networks, terminals, and users. An important solution to cope with such heterogeneity is content adaptation. This paper reviews the standardization issues related to content adaptation in IPTV standards. We first describe the basic architecture of content adaptation and its integration into the ITU-T IPTV architecture. Then typical methods of content adaptation in practical IPTV systems are discussed in detail. Especially, we highlight the standard metadata tools that are potential to support adaptation methods within ITU-T IPTV architecture. Some recent developments in other standard bodies are also discussed.
The polycomb group protein EZH2 impairs DNA repair in breast epithelial cells (2006)

The Polycomb group protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to aggressive and metastatic breast cancer. Here we report that EZH2 decreased the ex-pression of five RAD51 paralog proteins involved in homologous recombination (HR) repair of DNA double-strand breaks (RAD51B/RAD51L1, RAD51C/RAD51L2, RAD51D/RAD51L3, XRCC2, and XRCC3), but did not affect the levels of DMC1, a gene that only functions in meiosis. EZH2 overexpression impaired the forma-tion of RAD51 repair foci at sites of DNA breaks. Over-expression of EZH2 resulted in decreased cell survival and clonogenic capacity following DNA damage in-duced independently by etoposide and ionizing radia-tion. We suggest that EZH2 may contribute to breast tumorigenesis by specific downregulation of RAD51-like proteins and by impairment of HR repair. We pro-vide mechanistic insights into the function of EZH2 in mammalian cells and uncover a link between EZH2, a regulator of homeotic gene expression, and HR DNA repair. Our study paves the way for exploring the block-ade of EZH2 overexpression as a novel approach for the prevention and treatment of breast cancer.
Design and Implementation of an “Approximate” Communication System for Wireless Media Applications (2012)

<?Pub Dtl=""?> All practical wireless communication systems are prone to errors. At the symbol level, such wireless errors have a well-defined structure: When a receiver decodes a symbol erroneously, it is more likely that the decoded symbol is a good “approximation” of the transmitted symbol than a randomly chosen symbol among all possible transmitted symbols. Based on this property, we define approximate communication, a method that exploits this error structure to natively provide unequal error protection to data bits. Unlike traditional [forward error correction (FEC)-based] mechanisms of unequal error protection that consume additional network and spectrum resources to encode redundant data, the approximate communication technique achieves this property at the PHY layer without consuming any additional network or spectrum resources (apart from a minimal signaling overhead). Approximate communication is particularly useful to media delivery applications that can benefit significantly from unequal error protection of data bits. We show the usefulness of this method to such applications by designing and implementing an end-to-end media delivery system, called Apex. Our Software Defined Radio (SDR)-based experiments reveal that Apex can improve video quality by 5–20 dB [peak signal-to-noise ratio (PSNR)] across a diverse set of wireless conditions when compared to traditional approaches. We believe that mechanisms such as Apex can be a cornerstone in designing future wireless media delivery systems under any error-prone channel condition.
Compressive Seismic Imaging (2012)

Ideas from the field of compressive sensing are rapidly making their way into the geophysical realm. We believe that these concepts will motivate major changes in the way that our industry acquires, processes, and images seismic data. In preparation for these changes, we have undertaken an initiative to build a consistent framework for learning, investigating, and applying compressive sensing concepts to the full range of technologies used in seismic acquisition, processing, and imaging. We refer to this framework as Compressive Seismic Imaging (CSI). The components of our CSI framework include compressive sensing theory, acquisition design, processing and imaging algorithms, and the work flows that link these components into a complete system. A key element of our CSI program is the use of field trials to expose algorithms, processes, and people to the realities of deploying new technology in our industry. Before going to the field, we use extensive computer modeling to identify CSI concepts that are either ready for deployment, or require testing in the field to advance the technology. A number of 2D and 3D field trials were undertaken by ConocoPhillips in 2011 to test compressive sensing design ideas for seismic data acquisition. To date, we have acquired test datasets for validating CSI concepts for land, marine, and ocean bottom recording configurations. The key compressive sensing concepts we have tested so far include non-uniform sampling for sources and receivers, data reconstruction, simultaneous shooting, and source encoding. Initial results from these trials show that compressive sensing concepts have the potential to significantly improve acquisition efficiency. Use of the CSI framework has allowed us to quickly focus our attention on the most relevant problems for compressive sensing technology deployment, resulting in rapid progress in our understanding.
HETEROKARYON ANALYSIS OF THE GENETIC CONTROL OF PIGMENT SYNTHESIS IN CHICK EMBRYO MELANOCYTES (1982)

The genetic control of pigmentation was analyzed using five unlinked mutants, namely, c, pk, Bl, ev and l. Each mutant blocks or reduces pigmentation. Chick melanocyte cultures of each mutant type were fused to produce all ten possible pair combinations of nondividing heterokaryons. Heterokaryons were identified autoradiographically (One partner in each pair was labeled with 3H-thymidine.) Crosses produced comparable pairs of double heterozygotes that were analyzed in vivo and in vitro. Heterokaryon pairs were compared to their corresponding double heterozygotes.--Some combinations showed complementation and produced wild-type pigment. Others showed noncomplementation having little or no pigment. Double heterozygotes complemented each other except in the cases involving the dominant mutant, l. Four heterokaryon pairs gave different results from their corresponding double heterozygotes. The pk-Bl and pk-ev combinations failed to complement as heterokaryons but did complement as double heterozygotes. On the other hand the l-c and I-Bl combinations complemented as heterokaryons but not as double heterozygotes. Based on these differences it is hypothesized that the pk and I loci are nuclearly restricted regulatory elements. Examples in the literature from other systems are cited to support such a hypothesis.
Supplementary Figure 2 from Human Monoclonal Antibodies Targeting Nonoverlapping Epitopes on Insulin-like Growth Factor II as a Novel Type of Candidate Cancer Therapeutics (2023)

&lt;p&gt;PDF file, 330KB, Schematic representation and SDS-PAGE analysis of the IGF-II-specific antibodies.&lt;/p&gt;
Low-Depth Mechanisms for Quantum Optimization (2021)

By gaining intuition about the mechanisms by which quantum optimization algorithms solve problems, approaches are identified that substantially improve the performance of quantum algorithms for this task.
Further report on the propagation of spark-produced N waves through turbulence (1992)

A laboratory model experiment to study the effect of turbulence on waveform and rise time of sonic booms has previously been reported [B. Lipkens and D. T. Blackstock, J. Acoust. Soc. Am. 90, 2307(A) (1991)]. Electric sparks produce the N waves, which then propagate through turbulence generated by a plane jet. Downscaling of the model turbulence from atmospheric turbulence was designed to match downscaling of the model N wave (in terms of duration and rise time) from the sonic boom. Reported here are hot wire anemometry measurements of the jet, which confirm that the turbulence characteristics are indeed those of a classical plane jet. The measured values of the integral length scale, Taylor microscale, and Kolmogorov microscale show that the desired downscaling from atmospheric turbulence was achieved. Also reported are measurements that show how rise time and wave shape distortion vary with propagation distance through the jet, turbulence intensity, and peak amplitude of the N wave. [Work supported by NASA.]
Database Architectures for Modern Hardware (Dagstuhl Seminar 18251) (2019)

The requirements of emerging applications on the one hand and the trends in computing hardware and systems on the other hand demand a fundamental rethinking of current data management architectures. Based on the broad consensus that this rethinking requires expertise from different research disciplines, the goal of this seminar was to bring together researchers and practitioners from these areas representing both the software and hardware sides and to foster cross-cutting architectural discussions. The outcome of this seminar was not only an identification of promising hardware technologies and their exploitation in data management systems but also a set of use cases, studies, and experiments for new architectural concepts.
Evaluation of the Antiparasitic and Antifungal Activities of Synthetic Piperlongumine‐Type Cinnamide Derivatives: Booster Effect by Halogen Substituents (2023)

A series of synthetic N-acylpyrrolidone and -piperidone derivatives of the natural alkaloid piperlongumine were prepared and tested for their activities against Leishmania major and Toxoplasma gondii parasites. Replacement of one of the aryl meta-methoxy groups by halogens such as chlorine, bromine and iodine led to distinctly increased antiparasitic activities. For instance, the new bromo- and iodo-substituted compounds 3 b/c and 4 b/c showed strong activity against L. major promastigotes (IC<sub>50</sub> =4.5-5.8 μM). Their activities against L. major amastigotes were moderate. In addition, the new compounds 3 b, 3 c, and 4 a-c exhibited high activity against T. gondii parasites (IC<sub>50</sub> =2.0-3.5 μM) with considerable selectivities when taking their effects on non-malignant Vero cells into account. Notable antitrypanosomal activity against Trypanosoma brucei was also found for 4 b. Antifungal activity against Madurella mycetomatis was observed for compound 4 c at higher doses. Quantitative structure-activity relationship (QSAR) studies were carried out, and docking calculations of test compounds bound to tubulin revealed binding differences between the 2-pyrrolidone and 2-piperidone derivatives. Microtubules-destabilizing effects were observed for 4 b in T. b. brucei cells.
ChemInform Abstract: A Simple Method for Preparation of N‐Mono‐ and N,N‐Di‐alkylated α‐Amino Acids. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
EBSeq-HMM: a Bayesian approach for identifying gene-expression changes in ordered RNA-seq experiments (2015)

Supplementary data are available at Bioinformatics online.
Parasitic Characteristics and Insecticidal Effects of Asobara japonica on the Developmental Stage of Drosophila suzukii (2021)

We confirmed the parasitic characteristics of Asobara japonica according to the stage of development of Drosophila suzukii and observed the morphological differences between parasitized and unparasitized D. suzukii larvae and pupae. It was also confirmed that emergence period of A. japonica was longer than that of D. suzukii. A. japonica showed an effective parasitic and insecticidal effect on D. suzukii larvae, and it is expected that A. japonica could be used as a natural enemy for the control of D. suzukii.
Development of a flip-chip composite interconnection system (2012)

MMP, MTG and PMG. In particular, I would like to extend my greatest appreciation to Mr Fan Wei for assisting in the test instrumentation, Ms Lu Haijing in the plating evaluations, Dr Yi Ming in the FEM, Mr Cheng Chek Kweng in the assembly setup
Trinuclear Pd3O2 Intermediate in Aerobic Oxidation Catalysis (2014)

The activation of O2 is a key step in selective catalytic aerobic oxidation reactions mediated by transition metals. The bridging trinuclear palladium species, [(LPd(II))3(μ(3)-O)2](2+) (L=2,9-dimethylphenanthroline), was identified during the [LPd(OAc)]2(OTf)2-catalyzed aerobic oxidation of 1,2-propanediol. Independent synthesis, structural characterization, and catalytic studies of the trinuclear compound show that it is a product of oxygen activation by reduced palladium species and is a competent intermediate in the catalytic aerobic oxidation of alcohols. The formation and catalytic activity of the trinuclear Pd3O2 species illuminates a multinuclear pathway for aerobic oxidation reactions catalyzed by Pd complexes.
Organic-inorganic hybrids with well-defined structures using synchronous polymerization methodologies (1996)

A critical challenge in the design of inorganic/organic composites is control over the mixing between the two chemically dissimilar phases. Although general thermodynamic considerations tend to favor phase separation, this spontaneous bias can be preempted by kinetics. Along these lines, we have been interested in forming unusual composite morphologies using kinetically controlled routes. In particular we have used an adaptation of the sol-gel process that involves the replacement of the traditional aliphatic alkoxide groups with polymerizable alkoxides. Upon hydrolysis to form the inorganic SiO{sub 2} network, the liberated unsaturated alcohols can be polymerized to produce mutually interpenetrating organic-inorganic network materials. Under the right conditions, mixing near the molecular level can be achieved. By and large, the inorganic components formed using this synchronous polymerization process are amorphous silicates. Recently, we have been interested in developing in situ routes into molecular composites that possess inorganic phases with well-defined structures (fibers, tubes. spheres, sheets, etc.). Our progress in this area will be discussed.
Laser mode locking over one octave: route to phase-stable few-cycle pulse generation (2000)

6-fs, 1-MW laser pulses have been produced at the full repetition rate of a mode-locked laser upon simultaneous synthesization of phase-locked laser modes over the spectral range extending from 500 nm to 1100 nm, opening the door to the measurement and stabilization of the absolute phase of few-cycle light pulses by use time- and frequency-domain techniques, respectively.
Efficacy of anti-PD-1 therapy in patients with melanoma brain metastases (2017)

IC responses to anti-PD-1 antibodies occur in pts with BM, including those with symptomatic BM requiring corticosteroids. Prospective trials evaluating anti-PD-1 therapy in pts with BM are underway.
PyZDDE: Release 2.0.0 (2015)

Zemax/ OpticStudio standalone extension using Python
Association between obesity and clinical prognosis in patients infected with SARS-CoV-2 (2020)

Our study found BMI was significantly associated with clinical manifestations and prognosis of patients with SARS-CoV-2 infection. For patients with increased risk, clinicians should intervene promptly to avoid disease progression.