gebhart/patrepeval huggingface dataset:
0194 Marketing 101: Learning how to market yourself for a successful career (2016)

The animal science industry can be a competitive marketplace as new graduates begin to look for a new job. Having good grades, the right skill set (laboratory experience, publication experience, good grades, etc.) and work experience (collecting samples, computer experience, working with animals, etc.) is not always enough to secure employment. Especially in a competitive job market. As a result, identifying ways to stand out from the crowd becomes important. Unfortunately, most job candidates do not realize that it is important to learn how to market and sell yourself to your target audience to meet their current and future business goals. How you market and sell yourself will be career and industry dependent (academia vs. consumer goods vs. pharma). Marketing and selling yourself does not end once you get your foot in the door. Marketing and selling yourself continues as you advance in your career. Although it is not as formal as the interview, marketing yourself requires you to network, communicate and engage management inside & outside your department. In addition, looking for new opportunities to build your credentials (board certification, become the “go to” person) and identifying ways to be unique will help set you apart and differentiate you from your peers. In this session, some of these key strategies will be discussed and how they can be applied for a successful career.
Cellular response of a novel PLK inhibitor in breast cancer cells (2008)

AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA

2397 

Polo-like kinase 1 (PLK1) is a serine/threonine protein kinase with several important functions throughout the G2→M phase of the cell cycle. Previous data has shown PLK1 to be highly expressed in malignant cells and its expression portends poor prognosis in various human cancer. Therefore, Plk1 is a potential oncology drug target, and several small molecules including GSK461364 are being developed to target PLK1 and are in clinical trials. We describe here analyses of molecular responses to GSK461364. With this background, we measured responses to GSK461364 in a panel of 50 breast cell lines. GSK461364 inhibited cell growth with a GI50 range between 0.1nM to 8 µM. GSK461364 also induced cell apoptosis, and inhibited cell proliferation and G2/M arrest by high content imaging. Subtype analysis of responses to the breast cancer cell lines showed GSK461364 to be more cytotoxic in lines representing clinically aggressive basal B breast cancers sub-type than in luminal sub-type cell lines or nontransformed human mammary epithelial cultures. Predictive biomarkers of response to GSK461364 treatment were discovered by supervising genomic and mRNA expression signatures of cell lines with the GI50 profile of GSK461364. While further validation of these candidate biomarkers is needed, such predictors could be used to enrich patient populations for potential responders prior to initiating therapy in the clinic and to define tailored therapeutics for individual patients. (Supported by funds from NIH/NCI U54 CA112970, ASCO and GlaxoSmithKline)
The Recruitment of SOX/OCT Complexes and the Differential Activity of HOXA1 and HOXB1 Modulate the Hoxb1Auto-regulatory Enhancer Function (2001)

Regionally restricted expression patterns of Hox genes in developing embryos rely on auto-, cross-, and para-regulatory transcriptional elements. One example is the Hoxb1 auto-regulatory element (b1-ARE), which drives expression of Hoxb1 in the fourth rhombomere of the hindbrain. We previously showed that HOXB1 and PBX1 activate transcription from the b1-ARE by binding to sequences required for the expression of a reporter gene in rhombomere 4 in vivo. We now report that in embryonal carcinoma cells, which retain characteristics of primitive neuroectodermal cells, the b1-ARE displays higher basal and HOX/PBX-induced activities than in other cell backgrounds. We have identified a bipartite-binding site for SOX/OCT heterodimers within the b1-ARE that accounts for its cell context-specific activity and is required for maximal transcriptional activity of HOX/PBX complexes in embryonal carcinoma cells. Furthermore, we found that in an embryonal carcinoma cell background, HOXB1 has a significantly higher transcriptional activity than its paralog HOXA1. We map the determinants for this differential activity within the HOXB1 N-terminal transcriptional activation domain. By using analysis in transgenic and HOXA1 mutant mice, we extended these findings on the differential activities of HOXA1 and HOXB1 in vivo, and we demonstrated that they are important for regulating aspects of HOXB1 expression in the hindbrain. We found that mutation of the SOX/OCT site and targeted inactivation of Hoxa1 both impair the response of the b1-ARE to retinoic acid in transgenic mice. Our results show that Hoxa1 is the primary mediator of the response of b1-ARE to retinoic acid in vivo and that this function is dependent on the binding of SOX/OCT heterodimers to the b1-ARE. These results uncover novel functional differences between Hox paralogs and their modulators.
Corrections to “Zinc Oxide Nanostructures and High Electron Mobility Nanocomposite Thin Film Transistors” [Nov 08 3001-3011 (2008)

In our paper [F.M. Li et al., 2008], two errors were noticed after the paper went to press. On page 3002, near the middle of the left column, it should say "In this method, zinc oxide and carbon powders are mixed together, usually in a ZnO:C ratio of 1: 1 or 1:4 by weight." In Fig. 8, on page 3005, the x-axis label should say "energy (eV)" instead of "wavelength (eV)." Also, this paper should have been designated as Invited, as it is now above.
Tandem Mass Spectrometry for the Direct Assay of Lysosomal Enzymes in Dried Blood Spots: Application to Screening Newborns for Mucopolysaccharidosis I (2008)

This newly developed tandem mass spectrometry assay has the potential to be adopted for newborn screening of mucopolysaccharidosis I. This assay has advantages over a previously reported assay also developed in this laboratory and has the potential to be performed in a multiplex fashion to measure several lysosomal enzymes relevant to treatable lysosomal storage diseases.
I want to be Sachin Tendulkar! (2013)

We present a mobile phone based cricket game for improving the spoken English pronunciation of school children designed and tested within a specific socio-cultural context in rural India, the Mewat district of Haryana State. The development of the game concept was informed by a field study, which identified the cultural restrictions respected by the community as well community interests and motivations. The game was accessible using a low-end mobile phone and evaluated with a group of 63 students from classes 4 and 5 of a rural school. The results suggest that the cricket game can be effectively used to engage students and to improve their spoken English skills in the given setting. Further, the game serves as an informative example of how factors impacting the acceptability and appropriation of a technology in a particular setting can be taken into account from the very beginning of the design process.
Inside Cover: Ionothermal Synthesis of an Aluminophosphate Molecular Sieve with 20‐Ring Pore Openings (Angew. Chem. Int. Ed. 31/2010) (2010)

The crystalline aluminophosphate molecular sieve with the largest pore openings (20MR) to date, DNL-1, has been prepared. In their Communication on page 5367 ff., Z. Tian and co-workers describe the ionothermal synthesis of DNL-1 and the confirmation of its structure by Rietveld refinement of PXRD and NMR analysis. Compared with its zeolite analogue of gallophosphate cloverite, DNL-1 exhibits excellent stability, which suggests potential applications in separation, catalysis, and gas storage.
Measuring missing heritability: Inferring the contribution of common variants (2014)

Genome-wide association studies (GWASs), also called common variant association studies (CVASs), have uncovered thousands of genetic variants associated with hundreds of diseases. However, the variants that reach statistical significance typically explain only a small fraction of the heritability. One explanation for the "missing heritability" is that there are many additional disease-associated common variants whose effects are too small to detect with current sample sizes. It therefore is useful to have methods to quantify the heritability due to common variation, without having to identify all causal variants. Recent studies applied restricted maximum likelihood (REML) estimation to case-control studies for diseases. Here, we show that REML considerably underestimates the fraction of heritability due to common variation in this setting. The degree of underestimation increases with the rarity of disease, the heritability of the disease, and the size of the sample. Instead, we develop a general framework for heritability estimation, called phenotype correlation-genotype correlation (PCGC) regression, which generalizes the well-known Haseman-Elston regression method. We show that PCGC regression yields unbiased estimates. Applying PCGC regression to six diseases, we estimate the proportion of the phenotypic variance due to common variants to range from 25% to 56% and the proportion of heritability due to common variants from 41% to 68% (mean 60%). These results suggest that common variants may explain at least half the heritability for many diseases. PCGC regression also is readily applicable to other settings, including analyzing extreme-phenotype studies and adjusting for covariates such as sex, age, and population structure.
ChemInform Abstract: Synthesis and Use of 5‐Vinyl‐1,2,4‐oxadiazoles as Michael Acceptors. A Rapid Synthesis of the Potent Muscarinic Agonist L‐670,548. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Scanning transmission X‐ray microscopy study of microbial calcification (2004)

ABSTRACT Calcium phosphates and calcium carbonates are among the most prevalent minerals involved in microbial fossilization. Characterization of both the organic and mineral components in biomineralized samples is, however, usually difficult at the appropriate spatial resolution (i.e. at the submicrometer scale). Scanning transmission X‐ray microscopy (STXM) was used to measure C K‐edge, P L‐edge, and Ca L‐edge near‐edge X‐ray absorption fine structure (NEXAFS) spectra of some calcium‐containing minerals common in biomineralization processes and to study the experimental biomineralization by the model microorganism, Caulobacter crescentus . We show that the Ca L 2,3 ‐edges for hydroxyapatite, calcite, vaterite, and aragonite are unique and can be used as probes to detect these different mineral phases. Using these results, we showed that C. crescentus cells, when cultured in the presence of high calcium concentration, precipitated carbonate hydroxyapatite. In parallel, we detected proteins, polysaccharides, and nucleic acids in the mineralizing bacteria at the single‐cell scale. Finally, we discussed the utility of STXM for the study of natural fossilized microbial systems.
Abstract 18003: Left Ventricular Long Axis Function Assessed During Routine Cine-Cardiac Magnetic Resonance Imaging is an Independent Predictor of Mortality in Patients With Reduced Ejection Fraction: A Multicenter Study (2016)

Introduction: Left ventricular contraction involves a complex interplay between myocardial fibers orientated in the longitudinal, oblique and circumferential directions. Long axis function appears to play a fundamental role in cardiac mechanics and there is increasing evidence that it may provide independent prognostic information in a number of disease states. The aim of this study was to evaluate the prognostic value of lateral mitral annular plane systolic excursion (MAPSE) as an index of long axis function, in a large multicenter population of patients with reduced ejection fraction (EF) undergoing CMR. Hypothesis: Long axis function measured using lateral MAPSE during routine cine-CMR is an independent predictor of mortality in patients with reduced EF. Methods: Data analysis was performed on 619 consecutive patients with EF<40% undergoing CMR with cine and late gadolinium enhancement (LGE) imaging at 4 US hospitals. Lateral MAPSE was measured in the 4-chamber cine view as the simple displacement of ...
Network Operations (2017)

This chapter describes the traditional role of network-facing operations and how moving to a network cloud will impact that role. We intend to motivate the need for innovation in the delivery of network-based services by demonstrating the cost drivers in operations. The move to NFV/SDN and ONAP enables not only faster time to market for new services but also significant reduction in operational cost, a main component of a service provider's cost of doing business.
SAT-317 INFLEUNZA VACCINATION RECALL IMMUNE RESPONSES QUANTIFICATION IN CHIMERIC RENAL TRANSPLANT RECEIPITS AT A SINGLE CELL LEVEL &amp; HIA (2020)

Drug-based immunosuppression significantly increases the risk of infection and cancer. Development of new approaches to minimize or eliminate graft rejection is of great interest to the transplant community. Establishment of durable hematopoietic chimerism through hematopoietic stem cell transplantation (HSCT) has been shown in preclinical models and patients to lead to donor specific tolerance. Those chimeric patients immune competence to virus infection never been investigated. Herein, we investigated the recall immune responses in a series of chimeric renal transplant recipients received CD8+/TCR- facilitating cell-based hematopoietic stem cell transplant (termed FCRx) to induce tolerance to mismatched renal allografts.
Wilson disease: more complex than just simply a copper overload condition?—a narrative review (2022)

Background and Objective: The therapeutic arsenal in Wilson disease is limited, but effective. It focuses on copper depletion, although this has never been defined nor measured. Accordingly, disorder adapted long term dosing strategies are missing. Goal of the analysis was the elucidation of copper metabolism in Wilson disease to detect critical mechanisms inducing cell injury and strategies for prevention. Methods: We seeked the literature between years 1980–2022 under the following key words: mechanism of liver injury in Wilson disease, therapeutic strategies, monitoring and outcome. Key Content and Findings: Copper is absorbed by intestinal mucosa depending on its content in diet. Release in bile controls the copper balance. In Wilson disease biliary copper excretion is genetically diminished and copper accumulates in hepatocytes mainly bound to metallothionein. Hepatocellular copper overload leads to release in blood for excretion in urine and distribution to other organs, preferentially to the basal ganglia of the brain. Excess of intracellular free copper bears the risk of parenchymal damage, e.g., hepatic and neurologic manifestation. One therapeutic approach intends the reduction of free copper in blood by chelation and consequent enhanced urinary excretion. As alternative therapy the oral application of zinc is possible. Zinc is a very potent metallothionein inducer operative mainly in mucosal cell, but also in hepatocytes. Metallothionein copper complexes caught in mucosal cells are lost with their desquamation and, thus, intestinal copper absorption is reduced. Conclusions: It is the free copper which induces the organ manifestation in Wilson disease and represents the target of therapy.
Structural diversity of the SARS-CoV-2 Omicron spike (2022)

Aided by extensive spike protein mutation, the SARS-CoV-2 Omicron variant overtook the previously dominant Delta variant. Spike conformation plays an essential role in SARS-CoV-2 evolution via changes in receptor binding domain (RBD) and neutralizing antibody epitope presentation affecting virus transmissibility and immune evasion. Here, we determine cryo-EM structures of the Omicron and Delta spikes to understand the conformational impacts of mutations in each. The Omicron spike structure revealed an unusually tightly packed RBD organization with long range impacts that were not observed in the Delta spike. Binding and crystallography revealed increased flexibility at the functionally critical fusion peptide site in the Omicron spike. These results reveal a highly evolved Omicron spike architecture with possible impacts on its high levels of immune evasion and transmissibility.
Indentation and oxidation studies on silicon nitride joints (1996)

Si nitride ceramics have been joined with a Y oxide-SiO{sub 2} interlayer. A 1:2 molar ratio of Y{sub 2}O{sub 3} to SiO{sub 2} was chosen to obtain the desired Y{sub 2}Si{sub 2}O{sub 7} stoichiometry, which should give the interlayer better oxidation resistance compared to other interlayer materials. Mechanical characterization of the joints performed by indentation shows it to have good room temperature strength.
Cooperative and selfish behaviour in unlicensed spectrum using the CSMA/CA protocol (2004)

It can be shown that in a communication system which uses CSMA/CA for medium access control greedy behavior can be discouraged by punishing the greedy users. However in a real system it is not always possible to punish a misbehaving user. Actually numerical experiments show that it is difficult to achieve enough punishment do discourage greediness since it takes time to detect that a user misbehaves and the time that a user can be punished is limited.
RBD- specific Th1 responses are associated with vaccine-induced protection against SARS-CoV-2 infection in patients with hematological malignancies (2023)

The SARS-CoV-2 pandemic still represents a threat for immunosuppressed and hematological malignancy (HM) bearing patients, causing increased morbidity and mortality. Given the low anti-SARSCoV-2 IgG titers post-vaccination, the COVID-19 threat prompted the prophylactic use of engineered anti-SARS-CoV-2 monoclonal antibodies. In addition, potential clinical significance of T cell responses has been overlooked during the first waves of the pandemic, calling for additional in-depth studies. We reported that the polarity and the repertoire of T cell immune responses govern the susceptibility to SARS-CoV-2 infection in health care workers and solid cancer patients. Here, we longitudinally analyzed humoral and cellular immune responses at each BNT162b2 mRNA vaccine injection in 47 HM patients under therapy. Only one-third of HM, mostly multiple myeloma (MM) bearing patients, could mount S1-RBD-specific IgG responses following BNT162b2 mRNA vaccines. This vaccine elicited a S1-RBD-specific Th1 immune response in about 20% patients, mostly in MM and Hodgkin lymphoma, while exacerbating Th2 responses in the 10% cases that presented this recognition pattern at baseline (mostly rituximab-treated patients). Performing a third booster barely improved the percentage of patients developing an S1-RBD-specific Th1 immunity and failed to seroconvert additional HM patients. Finally, 16 patients were infected with SARS-CoV-2, of whom 6 developed a severe infection. Only S1-RBD-specific Th1 responses were associated with protection against SARS-CoV2 infection, while Th2 responses or anti-S1-RBD IgG titers failed to correlate with protection. These findings herald the paramount relevance of vaccine-induced Th1 immune responses in hematological malignancies.
Naturalistic types (2011)

The typical properties of natural language - redundancy avoidance, locality, and immediacy - support high semantic density and improve readability, and therefore, are also interesting for the design of programming languages. To achieve these properties, natural language heavily relies on types, which are used for referencing, generalization, and description of instances. With naturalistic types we conceptualize the idea of natural language types for use in programming. This article demonstrates possible applications of naturalistic types for programming and gives a detailed analysis of their constituents - concepts, properties, quantities, and conditions.
Polyethylene Terephthalate Deconstruction Catalyzed by a Carbon‐Supported Single‐Site Molybdenum‐Dioxo Complex (2020)

Polyethylene terephthalate (PET) is selectively depolymerized by a carbon-supported single-site molybdenum-dioxo catalyst to terephthalic acid (PTA) and ethylene. The solventless reactions are most efficient under 1 atmosphere of H<sub>2</sub> . The catalyst exhibits high stability and can be recycled multiple times without loss of activity. Waste beverage bottle PET or a PET + polypropylene (PP) mixture (simulating the bottle + cap) proceeds at 260 °C with complete PET deconstruction and quantitative PTA isolation. Mechanistic studies with a model diester, 1,2-ethanediol dibenzoate, suggest the reaction proceeds by initial retro-hydroalkoxylation/β-C-O scission and subsequent hydrogenolysis of the vinyl benzoate intermediate.
Chain Stiffness of a High Molecular Weight Polyguanidine Prepared by Living Polymerization (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTChain Stiffness of a High Molecular Weight Polyguanidine Prepared by Living PolymerizationMu-Ping Nieh, Andrew A. Goodwin, Jennifer R. Stewart, Bruce M. Novak, and Dave A. HoaglandView Author Information Department of Polymer Science & Engineering and the Materials Research Science and Engineering Center, University of Massachusetts, Amherst, Massachusetts 01003 Cite this: Macromolecules 1998, 31, 9, 3151–3154Publication Date (Web):April 11, 1998Publication History Received10 December 1997Revised17 March 1998Published online11 April 1998Published inissue 1 May 1998https://pubs.acs.org/doi/10.1021/ma9718006https://doi.org/10.1021/ma9718006rapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views335Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Optical properties,Physical and chemical properties,Polymers,Scattering,Stiffness Get e-Alerts