gebhart/patrepeval huggingface dataset:
Challenges in determining death by neurologic criteria in extracorporeal membrane oxygenation – A single center experience (2023)

AT was used safely and successfully in 6 of the 8 ECMO patients diagnosed with DNC and was always consistent with the neurological exam and imaging findings, as opposed to ancillary tests alone.
Atomic Hydrogen Diffusion on Doped and Chemically Modified Graphene (2013)

To explore hydrogen mobility on graphene, density functional calculations are used to determine the magnitude of binding energy versus the diffusion barrier for graphene, considering the effects of hole and electron doping, B and N substitutional dopants, and oxygen heteroatoms. Although C–H binding energy and the barrier for chemical diffusion are not correlated, the binding energy of H in the lowest energy site on top of a C atom correlates with the binding energy of H over a “bridge” C–C bond, which is the transition state for chemical diffusion. Using this framework, we demonstrate that both B substitutionally doped graphene and hydoxylated graphene have the potential to simultaneously meet thermodynamic and kinetic constraints for reversible room-temperature hydrogenation. The constraints demonstrate that reversible room-temperature hydrogenation is possible only when H diffuses in a chemically bound state.
Multilevel optical sectioning based on digital holography with a femtosecond frequency comb laser (2012)

In this paper, we demonstrate how short coherence digital holography with a pulsed fiber laser frequency comb may be used for multi-level optical sectioning. For the proof of the principle, a conic object having a size of few centimeters is used. The object shape is obtained by digitally reconstructing and processing a sequence of holograms recorded during stepwise shifting of a spherical mirror in the reference arm of the holographic set-up. First experimental results are presented.
Abstract B284: Discovery of imidazopyridazinecarbonitriles as potent, selective inhibitors of CK2. (2013)

Abstract Casein kinase 2 (CK2) is a serine/threonine kinase that has been implicated in the regulation of a number of oncogenic or tumor suppressor proteins. CK2 activity has been shown to be elevated in numerous studies in a variety of cancer types. CK2 has been shown to phosphorylate numerous cellular proteins. Among the proteins regulated directly or indirectly by CK2 phosphorylation are oncogenes and tumor suppressor proteins including beta-catenin, c-Myc, PML, and PTEN as well as proteins directly involved in cell cycle, apoptosis, and transcriptional regulation. The plethora of CK2 substrates and their participation in various cellular processes is a major confounding factor in understanding the role of CK2 in oncogenesis. Unlike other kinase targets that participate in relatively linear growth factor signaling pathways, CK2 appears to function more “laterally,” across many important signaling pathways to promote growth and survival of cancer cells. It is clear from numerous studies using siRNA as well as small molecule CK2 inhibitors that cancer cells are highly dependent upon CK2 for growth and survival. As a result, new small molecule inhibitors of CK2 may provide useful tools for probing CK2 biology and may also provide therapeutic benefits against several cancer types. Herein, we report our efforts toward the identification of CK2 inhibitors based on an imidazopyridazine carbonitrile scaffold. Lead compounds from this series demonstrate low nanomolar CK2 biochemical potency, while achieving excellent selectivity versus the majority of kinases in the human kinome. The development of structure-activity relationships and the establishment of a strong correlation between biochemical potency, inhibition of cellular protein target phosphorylation and anti-proliferative effects in targeted cancer cell lines will be presented. In addition, the optimization of pharmacokinetic properties resulting in compounds with excellent in vivo exposure has allowed for the investigation of CK2 inhibition in a pharmacodynamic model. Finally, our efforts to elucidate pathway effects mediated by CK2 in model colon cancer cell lines, including gene expression profiling using advanced small molecules leads, will be disclosed. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):B284. Citation Format: Brian Fink, Ashvinikumar Gavai, Soong-Hoon Kim, Yufen Zhao, Ashok Purandare, Gregory Vite, John Tokarski, Chiang Yu, Benjamin Henley, Joseph Fargnoli, Heshani Desilva, Petra Ross-MacDonald, Brent Rupnow, Tai W. Wong. Discovery of imidazopyridazinecarbonitriles as potent, selective inhibitors of CK2. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr B284.
Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease (2010)

The polymorphisms C-482T and T-455C in APOC3 are associated with nonalcoholic fatty liver disease and insulin resistance.
An Efficient Ascending-Bid Auction for Multiple Objects: Reply (2018)

In a comment, Okamoto (2018 ) identifies and corrects a misspecification of the rationing rule in Ausubel (2004 ). This reply elaborates on the observation that the optimality of truthful bidding in dynamic auctions may be sensitive to the fine details of the rationing rule. It then discusses the wider role of sequential bid processing in restoring truthful bidding. (JEL D44)
DNA Sequencing apparatus (2023)

An automated DNA sequencing apparatus having a reactor for providing at least two series of DNA products formed from a single primer and a DNA strand, each DNA product of a series differing in molecular weight and having a chain terminating agent at one end; separating means for separating the DNA products to form a series bands, the intensity of substantially all nearby bands in a different series being different, band reading means for determining the position an This invention was made with government support including a grant from the U.S. Public Health Service, contract number AI-06045. The U.S. government has certain rights in the invention.
Compositional and mechanical properties of long bones of osteoactivin mutant mice (2012)

Osteoactivin(OA) is a protein found in bone and other tissues. However, the role of OA in bone formation and resorption has not been well-defined. The current study assessed the compositional and mechanical properties of long bones of OA mutant mice to further understanding of the role of OA. Data support the conclusion that lack of the OA protein results in increased bone formation, which is manifested as stronger, denser bones.
Immunological Modification of the Head and Neck Cancer Microenvironment by Short Chain Fatty Acids (2022)

Recently, immune checkpoint inhibitors (ICIs) have emerged as a new option for the treatment of head and neck cancer. However, improving their efficacy remains a challenge, and approaches to the tumor microenvironment are important. While intestinal bacteria and their metabolites, short-chain fatty acids (SCFAs), have attracted much attention, the effects of SCFAs on cancer and immune cells are still unclear. In this study, we decided to focus on SCFA-A, one of the SCFAs that have the strongest effect on immune activity in preliminary experiments, to clarify its effects on cancer and immune cells. By co-culturing cancer cells and T cells at different cell concentrations, we reproduced the three sequential phases of cancer immunoediting: cancer and T cells in equilibrium, cancer-dominant, and T cell-dominant. SCFA-A was directly added to the co-cultures of cancer cells and T cells. In addition, SCFA-A was orally administered to a tumor-bearing mouse model to clarify the mechanism of the anti-tumor effect of SCFA-A in the tumor microenvironment. SCFA-A inhibited tumor growth in the co-culture of cancer cells and T cells, and oral administration of SCFA-A to a tumor-bearing mouse model increased anti-PD-1 activity. This study is expected to improve the efficacy of the treatment of ICIs and may lead to drug discovery for cancer immunotherapy and the discovery of new biomarkers.
Signal detection via residence-time asymmetry in noisy bistable devices (2003)

We introduce a dynamical readout description for a wide class of nonlinear dynamic sensors operating in a noisy environment. The presence of weak unknown signals is assessed via the monitoring of the residence time in the metastable attractors of the system, in the presence of a known, usually time-periodic, bias signal. This operational scenario can mitigate the effects of sensor noise, providing a greatly simplified readout scheme, as well as significantly reduced processing procedures. Such devices can also show a wide variety of interesting dynamical features. This scheme for quantifying the response of a nonlinear dynamic device has been implemented in experiments involving a simple laboratory version of a fluxgate magnetometer. We present the results of the experiments and demonstrate that they match the theoretical predictions reasonably well.
ChemInform Abstract: Correlation of the Melting Points of Potential Ionic Liquids (Imidazolium Bromides and Benzimidazolium Bromides) Using the CODESSA Program. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Combined use of oligo(dt) and 28S cDNA probes for the quantitation of total mRNA in polyribosomes: Application to the castration-induced atrophy of the rat prostate (1990)

The castration-induced atrophy of the rat prostate was used as a model for the validation of a sensitive technique allowing the quantitation of total mRNA in polyribosomes. Electron micrographs of polyribosome samples showed a decrease in polyribosomes length 7 days after castration (GDX). Specificity of labeled oligo(dt) probe for poly(A) was demonstrated and the technique was successfully applied to demonstrate that GDX is associated with a decrease in poly(A) mRNA content of polyribosomes. Provided that normalization of the hybridization signal for mRNA is achieved with a rRNA cDNA probe, the assay therefore represents a suitable tool for further studies regarding the translational regulation of total and/or specific mRNAs.
Retrofit device and method to improve humidity control of vapor compression cooling systems (2023)

A method and device for improving moisture removal capacity of a vapor compression system is disclosed. The vapor compression system is started up with the evaporator blower initially set to a high speed. A relative humidity in a return air stream is measured with the evaporator blower operating at the high speed. If the measured humidity is above the predetermined high relative humidity value, the evaporator blower speed is reduced from the initially set high speed to the lowest possible speed. The device is a control board connected with the blower and uses a predetermined change in measured relative humidity to control the blower motor speed.
Electo-Optic Effects and Domain Reversal in Sr0.61Ba0.39Nb2O6 (1991)

We present the results of a comprehensive electro-optic (EO) study of Sr 0.61 Ba 0.39 Nb 2 O 6 at λ = 633 nm. The experiments are conducted in the transverse field configuration, hence the effective linear EO coefficient r c is measured. Uniformly poled samples yield r c = 230 ± 20 pm/V at 25°C and r c = 1600 ± 150 pm/V at 65°C. However, the EO behavior is found to substantially degrade when attempting domain reversal. Imaging a crystal through crossed polarizers during the reversal process shows a very non-uniform birefringence distribution in the vicinity of the original -c electrode face.
Electrical Characterization of a Single TiO2 Nanotube by Using Modified FIB/SEM (2006)

Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3, 2005
ChemInform Abstract: Zeolites and Molecular Sieves: Not Just Ordinary Catalysts (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The influence of different supports on the properties of the excavation damaged zone along the FE tunnel in the Mont Terri Underground Rock Laboratory (2016)

Abstract Permeability and its spatial distribution around an underground opening in a geological formation are important for the interpretation of thermal, hydraulic and mechanical findings from an in situ demonstration experiment. Within the site characterization programme of the Full-scale Emplacement (FE) experiment, permeability measurements with nitrogen gas have been conducted from six short boreholes. Four of them were located in a section without shotcrete support and two in a section with a three-layer-shotcrete lining. As expected, the extension of the zone with an increased permeability was larger (up to 2 m) in the area without shotcrete support than that in the section with a shotcrete lining (less than 1.5 m). The water content in the sections with or without shotcrete linings also showed different behaviour over long-term monitoring. The water content in the deep borehole section in the area with a shotcrete lining stayed almost constant, while the water content in the deep borehole section in the area without shotcrete tended to continuously decrease. In general, the water content close to the tunnel is influenced by the seasonal change in the temperature and relative humidity within the tunnel, especially in the section without a shotcrete lining. Analysis of the abovementioned observations/findings was done by performing FEM (finite-element method) calculations with OpenGeoSys (OGS) software using a coupled hydromechanical model. Owing to the high stiffness of shotcrete, the displacement in the section with a shotcrete lining was smaller. This, in turn, results in a smaller extension in the excavation damaged zone (EDZ). However, shotcrete has a relatively high suction capacity and high initial water content: thus, the interface between the shotcrete and the Opalinus Clay becomes more saturated. Therefore, the excavation-induced fractures in the Opalinus Clay close to the shotcrete can be sealed by swelling. The water content decreases continuously, as a result of desaturation occurring during the operational phase and the associated change in porewater pressure.
Paramagnetic Spin Labeling of a Bacterial DnaB Helicase for Solid-State NMR (2021)

Simulation scripts and input files for Rosetta simulations to model ensembles of DOTA and PROXYL spin labels on DnaB protein. In addition, R scripts to simulate signal decay curves due to paramagnetic relaxation in 2D DARR and 3D NCACB experiments with DOTA and PROXYL spin labels.
Association between investigator-measured body-mass index and colorectal adenoma: a systematic review and meta-analysis of 168,201 subjects (2017)

The objective of this meta-analysis is to evaluate the odds of colorectal adenoma (CRA) in colorectal cancer screening participants with different body mass index (BMI) levels, and examine if this association was different according to gender and ethnicity. The EMBASE and MEDLINE were searched to enroll high quality observational studies that examined the association between investigator-measured BMI and colonoscopy-diagnosed CRA. Data were independently extracted by two reviewers. A random-effects meta-analysis was conducted to estimate the summary odds ratio (SOR) for the association between BMI and CRA. The Cochran's Q statistic and I<sup>2</sup> analyses were used to assess the heterogeneity. A total of 17 studies (168,201 subjects) were included. When compared with subjects having BMI < 25, individuals with BMI 25-30 had significantly higher risk of CRA (SOR 1.44, 95% CI 1.30-1.61; I<sup>2</sup> = 43.0%). Subjects with BMI ≥ 30 had similarly higher risk of CRA (SOR 1.42, 95% CI 1.24-1.63; I<sup>2</sup> = 18.5%). The heterogeneity was mild to moderate among studies. The associations were significantly higher than estimates by previous meta-analyses. There was no publication bias detected (Egger's regression test, p = 0.584). Subgroup analysis showed that the magnitude of association was significantly higher in female than male subjects (SOR 1.43, 95% CI 1.30-1.58 vs. SOR 1.16, 95% CI 1.07-1.24; different among different ethnic groups (SOR 1.72, 1.44 and 0.88 in White, Asians and Africans, respectively) being insignificant in Africans; and no difference exists among different study designs. In summary, the risk conferred by BMI for CRA was significantly higher than that reported previously. These findings bear implications in CRA risk estimation.
High Performance Organic Transistors Using Small Molecule Semiconductors and High Permittivity Semiconducting Polymers (2014)

High mobility organic semiconductor formulations with excellent uniformity across large area substrates are prepared via the use of formulations containing small molecule and high permittivity semiconducting oligomers. The use of these high‐ k ( k &gt; 3.3) oligomers allows control of the wetting via the manipulation of the surface energy of the substrate being coated. Organic thin film transistors results with mobilities of up to 5 cm 2 V ‐1 s ‐1 , standard deviation &lt;10 %, on/off ratios of 10 9 are presented.
Toughened carbon fibre-reinforced polymer composites with nanoparticle-modified epoxy matrices (2016)

In the current work, the microstructure and fracture performance of carbon fibre-reinforced polymer (CFRP) composites based upon matrices of an anhydride-cured epoxy resin (formulated with a reactive diluent), and containing silica nanoparticles and/or polysiloxane core-shell rubber (CSR) nanoparticles, were investigated. Double cantilever beam tests were performed in order to determine the interlaminar fracture energy of the CFRP composites, while the single-edge-notched bend specimen was employed to evaluate the fracture energy of the bulk polymers. The fracture energy of the bulk epoxy polymers increased from 173 J/m 2 for the unmodified polymer to a maximum of 1237 J/ m 2 with the addition of 16 wt% of CSR nanoparticles. The toughening mechanisms were identified as (a) localised plastic shear yielding and (b) cavitation of the CSR particles followed by plastic void growth of the matrix. The steady-state propagation value of the interlaminar fracture energy of the CFRP composites increased with increasing nanoparticle concentration, from 1246 J/m 2 for the unmodified epoxy matrix to a maximum of 1851 J/m 2 with 4 wt% of silica nanoparticles and 8 wt% of CSR nanoparticles. Crack growth in the CFRP composites was dominated by fibre-bridging toughening mechanisms. The efficiency of the transfer of toughness from the bulk polymers to the carbon fibre composites was considered. The measured fracture energy of both bulk and composite materials decreased at a test temperature of -80 C, compared with room temperature, i.e. 20 C. Nevertheless, the toughening effects of both the silica and CSR nanoparticles on the bulk epoxy polymers and the CFRP composites, compared with the unmodified epoxy polymers, were still evident even at the lower temperature. Indeed, the toughening effect of the silica nanoparticles was greater at -80 C than at room temperature.
A Small Molecule That Binds and Inhibits the ETV1 Transcription Factor Oncoprotein (2014)

Members of the ETS transcription factor family have been implicated in several cancers, where they are often dysregulated by genomic derangement. ETS variant 1 (ETV1) is an ETS factor gene that undergoes chromosomal translocation in prostate cancers and Ewing sarcomas, amplification in melanomas, and lineage dysregulation in gastrointestinal stromal tumors. Pharmacologic perturbation of ETV1 would be appealing in these cancers; however, oncogenic transcription factors are often deemed "undruggable" by conventional methods. Here, we used small-molecule microarray screens to identify and characterize drug-like compounds that modulate the biologic function of ETV1. We identified the 1,3,5-triazine small molecule BRD32048 as a top candidate ETV1 perturbagen. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. Moreover, BRD32048 inhibits p300-dependent acetylation of ETV1, thereby promoting its degradation. These results point to a new avenue for pharmacologic ETV1 inhibition and may inform a general means to discover small molecule perturbagens of transcription factor oncoproteins.
Apolipoprotein E Peptide-Guided Disulfide-Cross-Linked Micelles for Targeted Delivery of Sorafenib to Hepatocellular Carcinoma (2019)

Sorafenib (SF) is an FDA-approved molecular-targeted drug for treating hepatocellular carcinoma (HCC). SF, however, suffers from poor water solubility, low bioavailability, dose-limiting side effects, and possible drug resistance. Here, we report on apolipoprotein E peptide-decorated disulfide-cross-linked micellar SF (ApoE-Ms-SF) as a targeted and intelligent formulation for HCC therapy. ApoE-Ms-SF was prepared with a good SF loading of 7.0 wt %, small size (37 nm), high stability, and reduction-triggered drug release from poly(ethylene glycol)-<i>b</i>-poly(ε-caprolactone-<i>co</i>-dithiolane trimethylene carbonate)-mefenamate (PEG-P(CL-DTC)-MA) and ApoE-modified ApoE-PEG-P(CL-DTC) block copolymers. MTT assays in low-density lipoprotein receptors (LDLRs) overexpressing SMMC-7721 human liver cancer cells showed ApoE density-dependent antitumor potency of ApoE-Ms-SF, in which 7.5% ApoE led to the best antitumor effect (IC<sub>50</sub>: 8.5 vs 23.3 μg/mL for free SF). Confocal studies, flow cytometry, western blot, and apoptotic assays illustrated clearly a more efficient uptake of ApoE-Ms than nontargeted Ms by SMMC-7721 cells as well as lower phosphorylated extracellular signal-regulated kinase protein level and better cell apoptosis caused by ApoE-Ms-SF compared with Ms-SF and free SF. ApoE-Ms-SF revealed a long circulation time (elimination half-life = 6.8 h). DiR-loaded ApoE-Ms showed a significantly higher accumulation in SMMC-7721 tumor than the nontargeted counterpart. The therapeutic outcomes in the orthotopic SMMC-7721 tumor models demonstrated that ApoE-Ms-SF reduced SF-associated side effects and brought about enhanced angiogenesis inhibition and tumor apoptosis compared to free SF and Ms-SF controls, leading to a better treatment of HCC.
Extending a Time-Triggered System by Event-Triggered Activities (2009)

Abstract—Time-triggered execution of periodic tasks provides the cornerstone of dependable real-time systems. In addition, there is often a need for executing event-triggered activities while the system would be otherwise idle. We first present the foundation of a time-triggered system based on the Timing Definition Language (TDL). Then we introduce event-triggered activities as an extension of the purely time-triggered programming model. If time-triggered and event-triggered activities exchange information among each other, the data flow must be synchronized such that reading unfinished output data is avoided. The paper describes a lock-free solution for these synchronization issues that is based exclusively on memory load and store operations and can be implemented efficiently on embedded systems without any operating system support. We also discuss the implications of our synchroni-zation approach for the semantics of combined time-triggered and event-triggered execution in a dependable real-time system. A case study of an Inertial Navigation System (INS) illustrates these extensions.