gebhart/patrepeval huggingface dataset:
Energy-Efficient Single Flux Quantum Technology (2011)

Figures of merit connecting processing capabilities with power dissipated (OpS/Watt, Joule/bit, etc.) are becoming dominant factors in choosing technologies for implementing the next generation of computing and communication network systems. Superconductivity is viewed as a technology capable of achieving higher energy efficiencies than other technologies. Static power dissipation of standard RSFQ logic, associated with dc bias resistors, is responsible for most of the circuit power dissipation. In this paper, we review and compare different superconductor digital technology approaches and logic families addressing this problem. We present a novel energy-efficient single flux quantum logic family, ERSFQ/eSFQ. We also discuss energy-efficient approaches for output data interface and overall cryosystem design.
Integrated GaN photonic circuits on silicon (100) for second harmonic generation (2011)

Second order optical nonlinearity is demonstrated in silicon architecture through heterogeneous integration of single-crystalline gallium nitride on silicon (100) substrates. The χ2 nonlinear susceptibility is measured to be as high as 16.4 ± 7.0 pm/V.
The Ludwig Institute for Cancer Research Melbourne Melanoma Cell Line Panel (2013)

We established a range of melanoma cell lines from patient material (Table 1) termed Ludwig-Melbourne-Melanoma (LM-MEL-) followed by a unique number (method: Anaka et al., 2012). These lines have been human leucocyte antigen (HLA)-typed, their mutational status for common mutated genes in melanoma determined using the Sequenom MelCarta panel, and their transcriptomes profiled. All lines are tested for mycoplasma, and ethical approval for research purposes has been granted by the Austin Health Human Research Ethics Committee (HREC). Therapeutic options for advanced stage melanoma are limited, and despite the recent success with inhibitors of mutant v-raf murine sarcoma viral oncogene homolog B1 (BRAF) activity, long-lasting responses remain rare (Chapman et al., 2011). Immunotherapy may help overcome treatment failure, and there has been some success in the clinic with immunotherapy agents (Hodi et al., 2010). Knowledge of the antigen presenting major histocompatibility complex (MHC) class I HLA-types and antigenic proteins expressed by model systems is crucial for the preclinical testing of immunological interventions such as therapeutic cancer vaccines. Cancer-testis antigens (CTAg) and differentiation-antigens [mainly regulated by the microphtalmia-associated transcription factor (MITF)], represent two of the most studied families of potential cancer vaccine targets in melanoma (Caballero and Chen, 2009); and show various degrees of tissue-restriction and immunogenicity. The expression levels of some of these ‘immune-targetable’ genes premelanosome protein (PMEL), melan-A(MLANA), tyrosinase (TYR) and members of the melanoma antigen family (MAGE) in the LM-MEL cell lines are shown as an example in Figure 1. The complete gene-expression data and available additional clinical data of the here presented cell line panel are accessible online at ArrayExpress (http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-1496/) and in Table S1. All cell lines are available upon request for a small handling fee or on a collaborative basis and slides for IHC from matched patient tumors and matched PBMCs/sera are accessible for some lines in limited quantities. AB is supported by a fellowship from the Cure Cancer Australia Foundation. JC and AB are supported by a grant from the Melanoma Research Alliance (MRA) and JC is supported by a practitioner fellowship from the Nation Health and Medical Research Council (NHMRC). This research was supported in part by the Cancer Council Victoria (CCV), the Austin Medical Research Foundation (AHMRF) and Operational Infrastructure Support Program Funding of the Victorian State Government. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Recent and emerging anti‐diabetes targets (2008)

Diabetes is a disease that affects over 150 million people worldwide for which there are multiple oral and injectable medications. Because of trends in obesity and sedentary lifestyles, diabetes rates in both developed and developing countries are increasing at an alarming rate. Current medications are not adequately effective in maintaining long-term glycemic control in most patients, even when used in combination, leaving diabetics susceptible to developing life threatening and debilitating complications such as cardiovascular disease, blindness, kidney complications, and amputations. Consequently, there is a critical need for more potent pharmacotherapies with novel mechanisms of action. A panel of 20 emerging diabetes targets is presented, and small molecule modulators for each target will be discussed.
Delving Deeper: Calculating Pythagorean Triples (2010)

Curious young minds can sometimes inspire one beyond all expectation.
Directional communication system for short-range vehicular communications (2010)

Improving safety in vehicles is achieved today by improving their ability to perceive and react to threats in the environment. Much effort is directed towards increasing the safety envelope around each vehicle with the introduction of increasingly sophisticated sensor technology (e.g., ultrasound, video, thermal imaging, and LIDAR). This envelope can also be increased by leveraging the exchange of safety messages between neighboring vehicles through localized communications between and among vehicles. This paper describes the requirements for messaging in a nearest-neighbor data interchange for several types of safety threats and makes a case for directional communications. The results of our analysis indicate performance limitations for omnidirectional communications and favors a directional scheme. The packet delay approaches 300ms for IEEE 802.11 at a density of 100 vehicles/km in saturation mode for backoff window parameter (W=128). This value is equivalent or close to the human reaction time and is considered unsuitable for safety messaging applicaitons. The design and development of a prototype directional communication system implemented with optical transceivers is described; its related application in providing improved situational awareness in conjunction with an in-car computer platform connected to a local GPS unit and on-board data monitoring interface is also described.
Sequential shrinkage and swelling underlie P2X(7)-stimulated lymphocyte phosphatidylserine exposure and death (2008)

International audience
Session details: Session 6A: Reliability and Debugging II (2016)

No abstract available.
Avoiding long propagation times in wave packet calculations on scattering with resonances: A new algorithm involving filter diagonalization (1997)

We present a new and more efficient implementation of a hybrid approach to computing the solution of scattering problems affected by resonances. In the computationally expensive part of the calculation, wave packet propagation is used to obtain the time-dependent wave function Ψ(t) up to some time τ at which direct scattering is over. This part is made efficient by using a recently introduced modification for the absorbing boundary conditions evolution operator which allows the use of real operator algebra if the initial wave function is chosen real. In the second part of the calculation, filter diagonalization is used to efficiently obtain the energies, widths, and expansion coefficients of resonances needed to describe the long time behavior of the scattering wave function. This part is made efficient by using a recently introduced algorithm which avoids the storage of energy-dependent basis functions. We demonstrate the application of the method to a two-dimensional reactive scattering problem.
Determining the Time to Maximal Bronchodilator Response in Asthmatic Children (2009)

We conclude that a minimal interval of 20 minutes, before re-testing spirometry, is required to document the maximal response to bronchodilators in the majority of asthmatic children.
E-Band 85-mW Oscillator and 1.3-W Amplifier ICs Using 0.12&#181;m GaN HEMTs for Millimeter-Wave Transceivers (2010)

This paper presents two oscillators (OSCs) and a high power amplifier (PA) for millimeter-wave transceivers. The circuits were designed with a grounded coplanar waveguide (GCPW) and 0.12-μm GaN HEMT technology. One OSC, which was based on a simple series source feedback topology, oscillated at a frequency of 74.5 GHz with an output power of 2.2 mW (3.38 dBm). This oscillation frequency was the highest ever reported for GaN HEMT OSCs. Another OSC with a buffer delivered a record power of 85 mW (19.28 dBm) at 70.75 GHz. In addition, a single-chip PA with a 3-stage common source scheme delivered an output power of 1.3 W (31.13 dBm) at 75 GHz with a CW source module. The 3-dB bandwidth of the PA was 13 GHz from 67 to 80 GHz. The performance of these devices is sufficient for use in E-band fixed wireless access systems and automotive radar systems. The results demonstrate that the GaN HEMTs represent a feasible means of addressing the stringent demands imposed by various millimeter-wave applications.
Barista: An Event-centric NOS Composition Framework for Software-Defined Networks (2018)

As the network operating system (NOS) is the strategic control center of a software-defined network (SDN), its design is critical to the welfare of the network. Contemporary research has largely focused on specialized NOSs that seek to optimize controller design across one or a few dimensions (e.g., scalability, performance, or security) due to fundamental differences in architectural trade-offs needed to support competing demands. We thus designed Barista, as a new framework that enables flexible and customizable instantiations of network operating systems (NOSs) supporting diverse design choices. The Barista framework incorporates two mechanisms to harmonize architectural differences across design choices: component synthesis and dynamic event control. First, the modular design of the Barista framework enables flexible composition of functionalities prevalent in contemporary SDN controllers. Second, its event-handling mechanism enables dynamic adjustment of control flows in a NOS. These capabilities allow operators to easily enable functionalities and dynamically handle associated events, thereby satisfying network operating requirements. Our results demonstrate that Barista can synthesize NOSs with many functionalities found in commodity NOSs with competitive performance profiles.
Outcome-based interpretation of early interim PET in advanced-stage Hodgkin lymphoma (2018)

The HD18 study for patients with newly diagnosed advanced-stage Hodgkin lymphoma (HL) used positron emission tomography (PET) after 2 cycles (PET-2) of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone in escalated doses (eBEACOPP) to guide further treatment. Here, we analyzed the impact of PET-2 results in the context of eBEACOPP according to the Deauville score (DS) in patients treated within the HD18 trial. Residual tissue was visually compared with reference regions according to DS. We analyzed the association between PET-2 uptake and baseline characteristics, progression-free survival (PFS), and overall survival (OS). One thousand five patients (52%) had DS1 or DS2, 471 (24%) had DS3, and 469 (24%) DS4. PET-2 uptake was associated with baseline risk factors large mediastinal mass, extranodal disease, and high International Prognostic Score (<i>P</i> < .0001 each). Among 722 patients receiving standard therapy with 6 cycles of eBEACOPP, 3-year PFS rates were 92.2%, 95.9%, and 87.6% with DS1-2, DS3, and DS4, respectively. Univariate hazard ratio (HR) for PFS in patients with DS4 vs DS1-3 was 2.3 (1.3-3.8; <i>P</i> = .002). DS4 was the only factor remaining significant for PFS in a multivariate analysis including the associated baseline risk factors. Three-year OS rates were 97.6% for DS1-2, 99.0% for DS3, and 96.8% for DS4, with a univariate HR for DS4 vs DS1-3 of 2.6 (1.0-6.6; <i>P</i> = .04). Residual uptake above that in the liver at PET-2 (ie, DS4) is an important risk factor regarding survival outcomes for patients treated with eBEACOPP upfront. We thus recommend DS4 as the cutoff value for PET-2 positivity. This trial was registered at www.clinicaltrials.gov as #NCT00515554.
Ultrafast Study ofp-Biphenylyldiazoethane. The Chemistry of the Diazo Excited State and the Relaxed Carbene (2007)

Ultrafast photolysis of p-biphenylyldiazoethane (BDE) produces an excited state of the diazo compound in acetonitrile, cyclohexane, and methanol with lambdamax = 490 nm and lifetimes of less than 300 fs. The decay of the diazo excited state correlates with the growth of singlet carbene absorption at 360 nm. The optical yields of diazo excited states produced by photolysis of p-biphenylyldiazomethane (BDM) and BDE are the same; however, the optical yield of singlet p-biphenylylmethylcarbene (1BpCMe) is 30-40% less than that of p-biphenylylcarbene (1BpCH) in all three solvents. The results are explained by rearrangement in the excited state (RIES) of BDE to form p-vinylbiphenyl (VB) in parallel with extrusion of nitrogen to form 1BpCMe in reduced yield. This interpretation is consistent with product studies (ethanol-OD in cyclohexane) which indicate that there is an approximately 25% yield of VB that is formed by a mechanism that bypasses the relaxed singlet carbene. The decay of 1BpCMe is biexponential, and that of 1BpCH is monoexponential. This is attributed either to efficient relaxation of vibrationally excited 1BpCMe by 1,2 migration of hydrogen to form VB (minor) or to the increased number of low-frequency vibrational modes provided by the methyl group (major). A methyl group retards the rate of intersystem crossing (ISC), relative to a hydrogen atom, and ISC is more rapid in nonpolar solvents. Reaction of 1BpCMe with methanol is much faster than spin equilibration. Both the lifetime of 1BpCMe and 1BpCH are the same in cyclohexane and in cyclohexane-d12. This demonstrates that spin equilibration is faster than reaction of either carbene with the solvent. The lifetimes of 1BpCMe and 1BpCMe-d3 are the same in cyclohexane. This indicates that 1,2 hydrogen migration of 1BpCMe to form VB is slower than spin equilibration in cyclohexane. In acetonitrile, however, the lifetime of 1BpCMe-d3 is 1.5 times longer than that of 1BpCMe in the same solvent. Thus, in acetonitrile, where ISC is slow, the rate of 1,2 hydrogen shift of 1BpCMe is competitive with ISC. In cyclohexene, the lifetime of 1BpCH is shortened relative to that in cyclohexane. The lifetime of 1BpCMe is the same in cyclohexene and cyclohexane. The data indicate that spin relaxation is slow relative to reaction of 1BpCH with neat alkene but that spin relaxation is fast for 1BpCMe relative to reaction with neat cyclohexene.
Adjuvant Weekly Girentuximab Following Nephrectomy for High-Risk Renal Cell Carcinoma (2016)

clinicaltrials.gov Identifier: NCT00087022.
Body Centered Cubic Magnesium Niobium Hydride With Facile Room Temperature Absorption and Four Weight Percent Reversible Capacity (2013)

Abstract not Available.
Identifying invariant gait metrics for exoskeleton assistance (2017)

Exoskeletons have the potential to increase the independence and quality of life of patients with walking pathologies. To do this effectively, the exoskeleton requires a control paradigm that can determine the timing and magnitude of assistance that is suitable for the user's task and environment. This paper searches for a metric that can be optimised, enabling assistance to be applied without compromising the energy efficiency and stability of gait. Spatial and temporal, kinematic, kinetic, and other novel dynamic stability metrics were compared across three different assistance scenarios and five different walking contexts. Results demonstrated that three metrics: step width, medial-lateral centre of pressure displacement, and medial-lateral margin of stability were the most invariant. This result suggests dynamic stability metrics are optimised in human gait and therefore are potentially suitable metrics for optimising in an exoskeleton control paradigm.
XUV excitation of H2 using the third harmonic of a frequency-doubled dye laser (1983)

Abstract
Specificities of the Protein Phosphatases involved in the Regulation of Glycogen Metabolism in Rabbit Skeletal Muscle (1976)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
All-metal Ku-band Luneburg lens antenna based on variable parallel plate spacing Fakir bed of nails (2017)

This paper presents an all-metal parallel plate waveguide (PPW) Luneburg lens designed using an array of subwavelength Fakir bed of nails unit-cells. Variation of the metal post height and PPW-spacing modulates the effective refractive index. The lens operates in the Ku-band of frequencies, with more than 40% bandwidth, in a quasi-TEM mode. Broadband and low loss, with high directivity and wide field-of-view, this antenna could be an excellent candidate as a lens-like beamformer for multiple beams satellite communication applications.
Serum bilirubin levels are positively associated with glycemic variability in women with type 2 diabetes (2016)

Bilirubin level within the physiological range might be an independent predictor for glycemic variability in women with type 2 diabetes.
Real-Time Edge Classification: Optimal Offloading under Token Bucket Constraints (2020)

To deploy machine learning-based algorithms for real-time applications with strict latency constraints, we consider an edge-computing setting where a subset of inputs are offloaded to the edge for processing by an accurate but resource-intensive model, and the rest are processed only by a less-accurate model on the device itself. Both models have computational costs that match available compute resources, and process inputs with low-latency. But offloading incurs network delays, and to manage these delays to meet application deadlines, we use a token bucket to constrain the average rate and burst length of transmissions from the device. We introduce a Markov Decision Process-based framework to make offload decisions under these constraints, based on the local model's confidence and the token bucket state, with the goal of minimizing a specified error measure for the application. Beyond isolated decisions for individual devices, we also propose approaches to allow multiple devices connected to the same access switch to share their bursting allocation. We evaluate and analyze the policies derived using our framework on the standard ImageNet image classification benchmark.
Regression of left ventricular hypertrophy by angiotensin converting enzyme inhibitor in reduced renal mass hypertensive rats (1991)

The journal consistently attracts the most important and highly innovative papers from the current research; our commitment to rapid publication ensures that these are published in the fastest time possible. In addition to primary papers from world-renowned experts, the Journal contains authoritative reviews that summarize and evaluate the most significant recent developments. Also included are special reports, original short papers containing innovative and time-sensitive information. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. ​ Official Journal of the: International Society of Hypertension European Society of Hypertension
Tuning of strain and surface roughness of porous silicon layers for higher-quality seeds for epitaxial growth (2014)

81.40.-z Treatment of materials and its effects on microstructure, nanostructure, and properties; 81.05.Rm Porous materials; granular materials; 82.80.Ej X-ray, Mössbauer and other γ-ray spectroscopic analysis methods.
X-ray Tube Physics and Technology (2017)

A comprehensive treatment of the physics, history, technology, reliability, and commercial aspects of diagnostic X-ray sources can be found. The center line of the invisible X-ray focal spot where electrons impact the target and the center line of the visible glowing rectangular area are oriented in parallel, but askew by about half a focal spot width. The X-ray focal spot, where the X-rays emerge, is slightly wider than the white glowing hot zone where thermal radiation emerges with relatively high intensity. The chapter explains the working principle of an entire X-ray tube with a sample glass X-ray tube. The X-ray focal spot is kept at a fixed position relative to the tube housing by a stationary magnetic dipole field. According to Food and Drug Administration terminology, an X-ray source assembly is comprised of a tube and tube housing, which both make up the tube housing assembly, and a beam limiting device.
Human hair keratin network and curvature (2007)

The curly shape of the hair shaft seems to result from the asymmetric differentiation of the precortex. Hair fiber can thus be considered as a shape memory material.
Closed-Loop di/dt&amp;dv/dt control and dead time minimization of IGBTs in bridge leg configuration (2013)

In order to optimize the clamped inductive load (hard) switching behavior of IGBTs in voltage source power electronic converters, i.e. to ensure a defined switching behavior independent of the load current level, the DC-link voltage or the junction temperature, in recent publications an IGBT gate drive for controlling di <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C</sub> /dt and dv <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CE</sub> /dt has been proposed and experimentally verified for chopper circuits. In this paper, the necessary modifications of the gate drive concept for applications with IGBTs in bridge leg configuration are investigated. For the purpose of a safe operation and a minimum distortion of the generated output voltage waveform, a reciprocal interlocking of the bridge leg's IGBTs is introduced in addition. Finally, the proposed concept is experimentally verified for regular operation and for different types of short circuits of the load.
Synthesis and Properties of the Chromophore of the asFP595 Chromoprotein from Anemonia sulcata (2005)

A model compound for the chromophore within the purple nonfluorescent GFP-like chromoprotein asFP595 was synthesized. The postulated structure of the chromophore, 2-acetyl-4-(p-hydroxybenzylidene)-1-methyl-5-imidazolone, was taken from the high-resolution crystal structure analysis of intact asFP595 [Quillin, M. L., Anstrom, D., Shu, X., O'Leary, S., Kallio, K., Lukyanov, K. A., and Remington, S. J. (2005) Kindling Fluorescent Protein from Anemonia sulcata: Dark-State Structure at 1.38 A Resolution, Biochemistry 44, 5774-5787]. Erlenmeyer lactonization and oxidation of the methylene group attached to the heteroaromatic moiety with selenium dioxide were used at the key stages of the synthesis. The spectral properties of the model chromophore in solution and their dependence on the pH and polarity of the solvent were investigated. In water, the chromophore was found to exist in two forms, neutral and anionic, with a pK(a) of 7.1. In a dimethylformamide solution, the spectral properties of the anionic form closely match those of the native protein, demonstrating that under these conditions, the compound is an excellent model for the chromophore within native asFP595.