gebhart/patrepeval huggingface dataset:
A Human TATA Binding Protein-Related Protein with Altered DNA Binding Specificity Inhibits Transcription from Multiple Promoters and Activators (1999)

The TATA binding protein (TBP) plays a central role in eukaryotic and archael transcription initiation. We describe the isolation of a novel 23-kDa human protein that displays 41% identity to TBP and is expressed in most human tissue. Recombinant TBP-related protein (TRP) displayed barely detectable binding to consensus TATA box sequences but bound with slightly higher affinities to nonconsensus TATA sequences. TRP did not substitute for TBP in transcription reactions in vitro. However, addition of TRP potently inhibited basal and activated transcription from multiple promoters in vitro and in vivo. General transcription factors TFIIA and TFIIB bound glutathione S-transferase-TRP in solution but failed to stimulate TRP binding to DNA. Preincubation of TRP with TFIIA inhibited TBP-TFIIA-DNA complex formation and addition of TFIIA overcame TRP-mediated transcription repression. TRP transcriptional repression activity was specifically reduced by mutations in TRP that disrupt the TFIIA binding surface but not by mutations that disrupt the TFIIB or DNA binding surface of TRP. These results suggest that TFIIA is a primary target of TRP transcription inhibition and that TRP may modulate transcription by a novel mechanism involving the partial mimicry of TBP functions.
Deconstructing bile acid signaling pathways (2011)

Reference EPFL-CONF-171247View record in Web of Science Record created on 2011-12-16, modified on 2017-05-12
Al-2.91 Phase Separation (2021)

As increasingly smaller molecular materials and material structures are devised or developed for technological applications, the demands on the processes of lithography now routinely include feature sizes that are of the order of 10 nm. In reaching such a fine level of resolution, the methods of lithography have increased markedly in sophistication and brought into play 2terminology that is unfamiliar, on the one hand, to scientists tasked with the development of new lithographic materials or, on the other, to the engineers who design and operate the complex equipment that is required in modern-day processing. Publications produced by scientists need to be understood by engineers and vice versa, and these commonly arise from collaborative research that draws heavily on the terminology of two or more of the traditional disciplines. It is developments in polymer science and material science that lead progress in areas that cross traditional boundaries, such as microlithography. This document provides the exact definitions of a selection of unfamiliar terms that researchers and practitioners from different disciplines might encounter.
Low Crosstalk 125 µm-Cladding Multi-Core Fiber with Limited Air-Holes Fabricated with Over-Cladding Bundled Rods Technique (2017)

We realized a 125 µm-cladding four-core fiber with four air-holes using novel fabrication technique without any drilling process. Core-to-core crosstalk was reduced to −63 dB/km at 1550 nm by intentionally constructing the air-holes during the fabrication.
Recent Progress and Spectral Robustness Study for Mechanically Stacked Multi-junction Solar Cells (2010)

Multi‐terminal mechanically stacked multi‐junction solar cells are an attractive candidate for terrestrial concentrator photovoltaics applications. Unlike monolithically integrated multi‐junction solar cells which require current matching, all the available photon currents can be fully extracted from each junction of a mechanically stacked solar cell. Therefore, it has a high performance potential, and more importantly is less sensitive to spectrum variations. Lower losses due to current mismatch translate into a higher annual energy output for the mechanical stack. This paper presents the baseline processing developed at imec for the mechanical stacking process, and the most recent cell results by means of this technology. A GaAs‐Ge dual‐junction mechanically stacked multi‐junction solar cell is demonstrated, with 24.7% plus 2.52% under AM1.5g, and 27.7% plus 4.42% under 30Suns concentration. In addition, spectral sensitivity is studied for both monolithically stacked and mechanically stacked solar cells, to learn the influence of spectrum variations on multi‐junction solar cell performance. SMARTS model is used to predict the spectral irradiances, with solar radiation and meteorological elements from typical meteorological year 3 (TMY3) data set. The generated spectra are then fed into TCAD numerical simulation tool, to simulate the device performance. The simulation results show a reduced spectral sensitivity for mechanically stacked cell, and there is a 6% relative gain in annual energy production for the site studied (Las Vegas), compared with the monolithic stack.
A simple lithographic method for fabricating micro/nano multiscale structures (2006)

A simple method for fabricating micro/nanoscale hierarchical structures is presented using a two-step temperature-directed capillary molding technique. This lithographic method involves a sequential application of molding process in which a uniform polymer-coated surface is molded with a patterned mold by means of capillary force above the glass transition temperature of the polymer. Various microstructures and nanostructures were fabricated with minimum resolution down to ~ 50 nm with good reproducibility. Also contact angle measurements of water indicated that two wetting states coexist on a multiscale hierarchical structure where heterogeneous wetting is dominant for microstructure and homogeneous wetting for nanostructure. A simple theoretical model combining these two wetting states was presented, which was in good agreement with the experimental data. Using this approach, multiscale hierarchical structures for biomimetic functional surfaces can be fabricated with precise control over geometrical parameters and the wettability of a solid surface can be tailored in a controllable manner.
In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy (2018)

We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.
Autologous and allogeneic stem‐cell transplantation for transformed Waldenström macroglobulinemia (2023)

Introduction: The prognosis of histological transformation (HT) in Waldenström macroglobulinemia (WM) is unfavourable despite the use of diffuse large B-cell lymphoma-directed chemo-immunotherapy. The aim of this study was to evaluate the outcomes after autologous stem-cell transplantation (autoSCT) or allogeneic stem-cell transplantation (alloSCT) in patients with transformed WM. Methods: Patients who received autoSCT or alloSCT between January 1996 and December 2021 were identified in an international multicenter database of 285 patients with transformed WM. The primary end-point was overall survival (OS), calculated from the date of SCT to death from any cause. Secondary end-points were progression-free survival (PFS), incidence of relapse/progression and non-relapse mortality (NRM). Univariate and multivariate analyses were performed using the Cox proportional hazards model for OS and PFS only for the autoSCT cohort, due to the small sample size of the alloSCT cohort. Results: Fifty-six patients were included, 46 had received autoSCT and 10 alloSCT. The median time from HT diagnosis to SCT was 8 months (range, 2–76 months) for autoSCT and 7 months (range, 3–49 months) for alloSCT. The patients received a median of 2 lines of treatment for HT before SCT (range, 1 to 6 for autoSCT and 1 to 3 for alloSCT), and 89% (complete response (CR): 59%) and 80% (CR: 50%) of the patients had chemosensitive disease at the time of autoSCT and alloSCT, respectively. For autoSCT, the conditioning regimen was BEAM in 76% of the patients, and for alloSCT, reduced-intensity conditioning was used in 70% of the cases. The median follow-up time for the surviving patients was 5.5 years (95% CI, 2.8–7.1 years) from autoSCT and 12.6 years (95% CI, 2.7–14.4 years) from alloSCT. The 3-year estimates of OS, PFS and cumulative incidences of relapse and NRM were 57%, 44%, 54%, and 2% for autoSCT and 50%, 50%, 30%, and 20% for alloSCT, respectively. In the autoSCT cohort, CR at SCT was found to be associated with superior OS and PFS (3-year OS, 81% for CR vs. 23% for less than CR, P = 0.001 and 3-year PFS, 62% vs. 21%, P < 0.001) and less than 2 lines of therapy for HT with superior OS (3-year OS, 75% for 1 line vs. 36% for >1 line, P = 0.01). Keywords: Aggressive B-cell non-Hodgkin lymphoma, Stem Cell Transplant No conflicts of interests pertinent to the abstract.
Channel Power Excursions From Single-Step Channel Provisioning (2012)

Steady-state power excursions arising from channel-addition wavelength-switching events are measured as a function of spectral configuration and amplifier settings in an erbium-doped-fiber-amplifier- (EDFA-) based reconfigurable optical add&#x2013;drop multiplexer network, and they exhibit a maximum excursion of 4.5 dB after four spans of 40 km standard single-mode fiber and 5 EDFAs. A simple model is introduced to explain the power-coupling phenomena responsible for the power excursions. The results show that the maximum excursion is determined by the maximum mean gain difference between the existing and added channels and does not necessarily correspond to the maximum number of channels or input power change.
1273: Evidence for the Involvement of Spinal Endogenous ATP and P2X Receptors in Detrusor Overactivity in the Rats (2006)

You have accessJournal of UrologyDiscussed Poster, Tuesday, May 23, 2006, 1:00 - 4:00 pm1 Apr 20061273: Evidence for the Involvement of Spinal Endogenous ATP and P2X Receptors in Detrusor Overactivity in the Rats Hitoshi Masuda, Michael B. Chancellor, Kazunori Kihara, William C. de Groat, and Naoki Yoshimura Hitoshi MasudaHitoshi Masuda More articles by this author , Michael B. ChancellorMichael B. Chancellor More articles by this author , Kazunori KiharaKazunori Kihara More articles by this author , William C. de GroatWilliam C. de Groat More articles by this author , and Naoki YoshimuraNaoki Yoshimura More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33486-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1273: Evidence for the Involvement of Spinal Endogenous ATP and P2X Receptors in Detrusor Overactivity in the Rats." The Journal of Urology, 175(4S), p. 410 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 410 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Hitoshi Masuda More articles by this author Michael B. Chancellor More articles by this author Kazunori Kihara More articles by this author William C. de Groat More articles by this author Naoki Yoshimura More articles by this author Expand All Advertisement PDF downloadLoading ...
Effective Online Evaluation for Web Search (2019)

We present you a program of a balanced mix between an overview of academic achievements in the field of online evaluation and a portion of unique industrial practical experience shared by both the leading researchers and engineers from global Internet companies. First, we give basic knowledge from mathematical statistics. This is followed by foundations of main evaluation methods such as A/B testing, interleaving, and observational studies. Then, we share rich industrial experiences on constructing of an experimentation pipeline and evaluation metrics (emphasizing best practices and common pitfalls). A large part of our tutorial is devoted to modern and state-of-the-art techniques (including the ones based on machine learning) that allow to conduct online experimentation efficiently. We invite software engineers, designers, analysts, and managers of web services and software products, as well as beginners, advanced specialists, and researchers to learn how to make web service development effectively data-driven.
PSA doubling time (PSADT) and serum testosterone (T) during intermittent androgen deprivation (IAD) in patients with biochemically relapsed prostate cancer (BRCP; M0): Potential predictive implications. (2011)

150 Background: The systemic management of patients with BRPC remains controversial. IAD is commonly employed. Aims: To evaluate the PSA dynamics and serum T in pts with BRPC treated with IAD until the development of PSA refractoriness or clinical evidence of metastatic disease. Methods: Data were retrospectively analyzed in all pts with BRCP treated with GnRH at PSA thresholds according to pre-treatment PSADT (10-15ng/mL, 15-20, and 20-30 for PSADT ≤3 mos, 3-9 mos, and ≥ 9 ms, respectively) and continued until PSA nadir. Antiandrogen (AA) was added for PSA &gt; 1.0 ng/mL after 3 mos). Follow-up (FU) consisted of PSA and T q3 mos. Cycles were repeated at the above preselected PSA thresholds and continued until lack of PSA response. Scans were obtained prior to cycles and at the time of CRPC state. Mixed effects model was used to study PSADT change over cycles. Multivariate cox regression model was used to identify prognostic variables. Results: From 1995-2010, with a mean FU of 71 mos (range 22-183 months), 96 pts received a mean of 2.8 cycles (range 1-9) of IAD; 58 (60%) remain on treatment and 38 (40%) were switched to continuous ADT due to PSA refractoriness (n=11) or positive scans (n=27). PSADT at the first off treatment (tx) interval (mean 3.1, 0.59-30.5 range, median 2.3) was significantly shorter than the baseline (p&lt;0.0001; mean 9.7, range 0.27-53.9, median 7.34) but remained relatively stable (p=0.29) in subsequent cycles. PSADT adjusted for T recovery (≥3 ms after T recovery to ≥ 150 ng/dL) was significantly longer (p=0.006) than that based only on all PSA determinations (mean 5.4, range 1.31-30.5, median 3.7 versus mean 3.1, range 0.59-30.5, median 2.3). Significant factors associated with probability of PSA refractoriness were pre-IAD PSADT (≥ 6 vs &lt;6 ms), first off tx interval PSADT (≥3 ms vs &lt;3m), the use of AA during first tx cycle, and PSA nadir during the first tx interval (&lt;0.1 vs ≥0.1 ng/mL). Conclusions: Our data suggest that PSADT becomes shorter after the initial cycle of IAD and correlate with T recovery. PSA dynamics and need for AA to enhance PSA nadir are associated with PSA refractoriness in pts BRPC treated with IAD. No significant financial relationships to disclose.
Automatic Optimization of Multichannel Electrode Configurations for Robust Fetal Heart Rate Detection by Blind Source Separation (2022)

The method holds potential for long-term fetal monitoring, by dynamically choosing the optimal configuration.
Physics-based compact modeling framework for state-of-the-art and emerging STT-MRAM technology (2015)

A comprehensive compact modeling framework coupling quantum transport with magnetic dynamics has been developed for state-of-the-art and emerging STT-MRAMs. After validation with numerical simulation and experimental results, various transistor-MRAM cell architectures have been studied for their performance and variability. SOT-assisted MRAMs are found to have significant improvement on Erase time over conventional STT-MRAMs.
Effects of calcitriol, seocalcitol, and medium-chain triglyceride on a canine transitional cell carcinoma cell line. (2005)

Calcitriol and seocalcitol inhibited TCC cell growth via induction of cell cycle arrest and MCT enhanced this effect. Therefore, calcitriol and seocalcitol with MCT may have therapeutic potential for canine bladder cancer.
Data from HLA Class I–Associated Immunodominance Affects CTL Responsiveness to an ESO Recombinant Protein Tumor Antigen Vaccine (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Vaccination with full-length human tumor antigens aims at inducing or increasing antitumor immune responses, including CD8 CTL in cancer patients across the HLA barrier. We have recently reported that vaccination with a recombinant tumor-specific NY-ESO-1 (ESO) protein, administered with Montanide and CpG resulted in the induction of specific integrated antibody and CD4 T cell responses in all vaccinated patients examined, and significant CTL responses in half of them. Vaccine-induced CTL mostly recognized a single immunodominant region (ESO 81-110). The purpose of the present study was to identify genetic factor(s) distinguishing CTL responders from nonresponders.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We determined the HLA class I alleles expressed by CTL responders and nonresponders using high-resolution molecular typing. Using short overlapping peptides spanning the ESO immunodominant CTL region and HLA class I/ESO peptide tetramers, we determined the epitopes recognized by the majority of vaccine-induced CTL.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; CTL induced by vaccination with ESO protein mostly recognized distinct but closely overlapping epitopes restricted by a few frequently expressed HLA-B35 and HLA-Cw3 alleles. All CTL responders expressed at least one of the identified alleles, whereas none of the nonresponders expressed them.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Expression of HLA-B35 and HLA-Cw3 is associated with the induction of immunodominant CTL responses following vaccination with recombinant ESO protein. Because recombinant tumor-specific proteins are presently among the most promising candidate anticancer vaccines, our findings indicate that the monitoring of cancer vaccine trials should systematically include the assessment of HLA association with responsiveness.&lt;/p&gt;&lt;/div&gt;
Rapid Additive Qualification Using Probabilistics (RAQUP) (2020)

Assurance of structural integrity of additively manufactured parts requires the qualification of materials, processes and machines. For the original equipment manufacturer (OEM), the speed and cost of qualification is critical for competitive advantage. During the past two decades, GE Global Research has developed and advanced the state-of-the-art of a suite of primarily Bayesian probabilistic methods and tools that have been leveraged on a wide variety of aviation, power, oil and gas and other applications for performance, cost, quality and reliability. Recently we have been applying them to additive manufacturing related qualifications. This work provides an overview of these probabilistic methods and tools and shows an application that reduces cycle time by four to five times in the development of additive alloy families.
A Wave Superposition Method Based on Monopole Sources with Unique Solution for All Wave Numbers (2010)

Asimple solution for the uniqueness problem of the wave superposition method is proposed in this paper.Many authors have pointed out the discrete set of wavenumbers for which the solution of the underlying integral equations is not unique. So far, the usual solutions are theoretically sophisticated and/or numerically disadvantageous. Here, by adding some sources interior to the virtual surface defined by the wave superposition method, the uniqueness problem can be easily removedwith lowcomputational effort. Furthermore, dealing with simple monopoles, this method is well-suited for practical applications.
Weighted proportional window control of TCP traffic (2001)

Abstract This article describes a technique for weighted proportional window control of elastic traffic such as that generated by TCP. This is achieved through the modification of the receiver's advertised window of TCP connections sharing the bottleneck link while taking into account the price that each user of a connection has paid for the service and the total number of active connections sharing the bottleneck link. Copyright © 2001 John Wiley &amp; Sons, Ltd.
Are you the sort of person who would like this? Quantifying the typicality of aesthetic taste across seeing and hearing (2019)

Aesthetic experience seems both regular and idiosyncratic. On one hand, there are powerful regularities in what we tend to find attractive vs. unattractive. (For example, most of us prefer images of beaches to images of mud puddles.) On the other hand, what we like also varies dramatically from person to person: what one of us finds beautiful, another might find distasteful. What is the nature of such differences in aesthetic taste? They may in part be arbitrary—e.g. reflecting the random details of highly specific past judgments (such as liking red towels over blue ones because they were once cheaper). But they may also in part be systematic—reflecting deeper ways in which people differ from each other in terms of their perceptual and/or cognitive processing. We assessed the systematicity of aesthetic taste by exploring its typicality across seeing and hearing. A large group of people rated the aesthetic appeal of wide ranges of both visual images of scenes and objects (e.g. beaches, buildings, and books), and common environmental sounds (e.g. doorbells, dripping, and dialtones). Each person’s ‘taste typicality’ for each modality was quantified by correlating their individual ratings with the mean ratings for each stimulus—thus capturing how similar each individual’s aesthetic preferences are to those of the group as a whole. We discovered that these typicality scores were reliably correlated across seeing and hearing in multiple independent samples—even when controlling for rating reliability and differences in how peoples used the scales. In other words, if you’re the sort of person who has (a)typical aesthetic preferences for visual images, you’re more likely to also be the sort of person who has (a) typical aesthetic preferences for sounds. This suggests that one’s ‘taste typicality’ is not entirely arbitrary, but rather reflects deeper factors that operate across multiple sensory modalities.
julia: 0.4.3 bugfix release (2016)

We are pleased to present the 0.4.3 bugfix release. Binaries are available at http://julialang.org/downloads/. A prepared tarball (the output of make light-source-dist) is attached below in julia-0.4.3.tar.gz, use this if a source tarball is desired, as it contains a small amount of preparation that a simple archive of the git repository does not. For source builds in restricted environments (e.g. no network access) use the output of make full-source-dist attached below in julia-0.4.3-full.tar.gz as it already contains all dependencies pre-downloaded and ready for compilation.