gebhart/patrepeval huggingface dataset:
Financing lead triggers (2013)

Sales representatives must have access to meaningful and actionable intelligence about potential customers to be effective in their roles. Historically, GE Capital Americas sales reps identified leads by manually searching through news reports and financial statements either in print or online. Here we describe a system built to automate the collection and aggregation of information on companies, which is then mined to identify actionable sales leads. The Financing Lead Triggers system is comprised of three core components that perform information fusion, knowledge discovery and information visualization. Together these components extract raw data from disparate sources, fuse that data into information, and then automatically mine that information for actionable sales leads driven by a combination of expert-defined and statistically derived triggers. A web-based interface provides sales reps access to the company information and sales leads in a single location. The use of the Lead Triggers system has significantly improved the performance of the sales reps, providing them with actionable intelligence that has improved their productivity by 30-50%. In 2010, Lead Triggers provided leads on opportunities that represented over $44B in new deal commitments for GE Capital.
ERP Measures Assay the Degree of Expectancy Violation of Harmonic Contexts in Music (1995)

Abstract Expectancy violations of a highly constrained musical context were studied by presenting subjects with a chord sequence (I, IV, V) that generated a strong expectancy for a specific final chord, and then completing the sequence with either a "best-possible" (Tonic), harmonically plausible (Minor), or harmonically implausible (Dissonant) resolution. Subjects determined whether it was the best-possible resolution, and in one-half of the trials made their decision known with an overt response. Several ERP waveform components showed differences among resolution types, response conditions, and electrode locations. Among the affected components were two subclasses of the P300, the first of which (P3a) was largest in response to the Dissonant in both response conditions at all electrode sites. The area and peak amplitude of the P3b varied at several electrode sites as a function of the degree of expectancy violation represented by the resolutions. The peak latency of the P3b component reflected the behavioral response time measurement in which the Tonic and Dissonant were identified 300 msec more quickly than the Minor. A comparison between frequency and timedomain data analyses demonstrates several parallels, and it is concluded that both can serve to investigate the perception and processing of the probability structure underlying musical events and contexts.
<title>Infrared targets for testing and training</title> (2002)

We present a design for an IR scene projector for live-fire training applications, based on modification of a commercial-off-the-air laser-light-scene scanner retrofitted with a CO<SUB>2</SUB> laser and associated IR optics. Design goals include a reusable or at least very inexpensive shoot- through projection screen. This application calls for a wide projection field as compared to typical IR scene-projection systems intended for hardware in the loop testing.
Reovirus activated NK cells show enhanced cetuximab mediated antibody-dependent cellular cytotoxicity against colorectal cancer cells (2015)

Meeting abstracts The naturally occurring oncolytic virus, reovirus, exhibits cytotoxic effects on cancer cells. Reovirus is safe, and currently is in multiple clinical trials testing for the treatment of different cancers. NK cells are innate immune effectors that mediate antibody dependent
Effect of Shot Peening on Torsional Fatigue Strength of High Strength Spring Steel in Air and Corrosive Environments (2008)

Torsional fatigue tests were conducted for a spring steel, SUP7, with Vickers hardness of 480. The effect of shot peening on the torsional fatigue strength of smooth and artificially notched specimens in the corrosive environment and air was studied. The increase of the fatigue strength of smooth specimens in air by shot peening was relatively small, and the surface roughness due to peening did not reduced the fatigue strength. On the other hand, the fatigue strength of notched specimens increased greatly by shot peening and the notch sensitivity was reduced. In corrosion fatigue, the fatigue strength increased by shot peening in the medium life range. The strength of shot-peened specimens was reduced in the long life range around 107cycles and was approached to that of not-peened specimens. A similar improvement was observed for notched specimens in the medium life range, and the notch sensitivity was reduced by shot peening. The compression zone made by shot peening extended about 0.3mm below the surface, and relaxed by fatigue loading. The observation results on the cracking behavior and residual stress distribution were used to interpret the effect of shot peening on the fatigue strength of spring steel.
SAR443809: a selective inhibitor of the complement alternative pathway, targeting complement factor Bb (2023)

Dysregulated activation of the complement system is implicated in the onset or progression of several diseases. Most clinical-stage complement inhibitors target the inactive complement proteins present at high concentrations in plasma, which increases target-mediated drug disposition and necessitates high drug levels to sustain therapeutic inhibition. Furthermore, many efforts are aimed at inhibiting only terminal pathway activity, which leaves opsonin-mediated effector functions intact. We describe the discovery of SAR443809, a specific inhibitor of the alternative pathway C3/C5 convertase (C3bBb). SAR443809 selectively binds to the activated form of factor B (factor Bb) and inhibits alternative pathway activity by blocking the cleavage of C3, leaving the initiation of classical and lectin complement pathways unaffected. Ex vivo experiments with patient-derived paroxysmal nocturnal hemoglobinuria erythrocytes show that, although terminal pathway inhibition via C5 blockade can effectively inhibit hemolysis, proximal complement inhibition with SAR443809 inhibits both hemolysis and C3b deposition, abrogating the propensity for extravascular hemolysis. Finally, intravenous and subcutaneous administration of the antibody in nonhuman primates demonstrated sustained inhibition of complement activity for several weeks after injection. Overall, SAR443809 shows strong potential for treatment of alternative pathway-mediated disorders.
Advanced Compton Camera with the ability in electron tracking based on Micro Pixel Gas Detector for Medical Imaging (2006)

We have developed the electron tracking Compton camera (ETCC) with reconstructing the 3-D tracks of the scattered electron in Compton process in the range from sub-MeV to several MeV for both gamma-ray astronomy and medical imaging [Bhattacharya, D, et al., 2004; Kanbach, G, et al., 2004]. By measuring both the directions and energies of a recoil gamma ray and a scattered electron, the direction of the incident gamma ray is determined for each individual photon. Furthermore, a residual measured angle between the recoil electron and scattered gamma ray is powerful for the kinematical background-rejection. For the 3-D tracking of the electrons, the micro time projection chamber (mu-TPC) was developed, which consists of a new type of the micro pattern gas detector, or a micro pixel gas chamber (mu-PIC) [Kanbach, G, et al., 2004; Ochi, A, et al., 2001; Nagayoshi, T, et al., 2005]. The ETCC consists of this mu-TPC (10 cm cube) and the 6 times 6 times 3mm GSO crystal pixel arrays with a flat panel photo-multiplier surrounding the base and side of the mu-TPC for detecting the recoil gamma rays. The ETCC provided the gamma ray images of point sources between 120 keV and ~1 MeV with the angular esolution of 6 degree and 5 degree (FWHM) at 364 keV of <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">131</sup> iodine and 511 keV of <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">18</sup> F ion, respectively. Also the angle of the scattered electron was measured with the resolution of ~80 degree, by which most backgrounds were removed by the kinematical constraint. A mobile ETCC for medical imaging, which is fabricated in a 1 m cubic box, has been tested since October 2005. Here we present the imaging performances using both a phantom and a rat.
Performance of Overloaded MIMO-OFDM System with Repetition Code (2014)

This paper investigates the performance of an overloaded multiple-input multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) system with a repetition code. It has been demonstrated that diversity with block coding prevents the performance degradation induced by signal multiplexing. However, the computational complexity of a joint decoding scheme increases exponentially with the number of multiplexed signal streams. Thus, this paper proposes the use of a repetition code in the overloaded MIMO-OFDM system. In addition, QR decomposition with M-algorithm (QRM) maximum likelihood decoding (MLD) is applied to the decoding of the repetition code. QRM-MLD significantly reduces the amount of joint decoding complexity. In addition, virtual antennas are employed in order to increase the throughput that is reduced by the repetition code. It is shown that the proposed scheme reduces the complexity by about 1/48 for 6 signal streams with QPSK modulation while the BER degradation is less than 0.1dB at the BER of 10-3.
Probing the Solvent-Assisted Nucleation Pathway in Chemical Self-Assembly (2006)

Hierarchical self-assembly offers a powerful strategy for producing molecular nanostructures. Although widely used, the mechanistic details of self-assembly processes are poorly understood. We spectroscopically monitored a nucleation process in the self-assembly of p-conjugated molecules into helical supramolecular fibrillar structures. The data support a nucleation-growth pathway that gives rise to a remarkably high degree of cooperativity. Furthermore, we characterize a helical transition in the nucleating species before growth. The self-assembly process depends strongly on solvent structure, suggesting that an organized shell of solvent molecules plays an explicit role in rigidifying the aggregates and guiding them toward further assembly into bundles and/or gels.
Interrelations between anti-tumour activity, DNA breakage, and DNA binding kinetics for 9-aminoacridinecarboxamide anti-tumour agents. (1986)

For a series of 9-aminoacridinecarboxamides, anti-tumour activity in vivo and cytotoxicity in vitro are correlated directly with the ability of the compounds to cause DNA single-strand breaks and with their DNA-dissociation mechanisms and residence times. It is suggested that one important consequence of long DNA residence times may be an enhanced ability to cause DNA strand breaks by a non-oxidative mechanism.
Magnetic force microscope (MFM) imaging with electrodeposited tips (2002)

Since magnetic force microscopy images are influenced by magnetic properties of a tip apex, it is important to characterize its properties and to examine tip-sample interaction. The electrodeposition is useful to make various controlled magnetic tips. We made the MFM tips of electrodeposited FeNi, Co and FeCo films on electrically polished tungsten tips. For measuring a strong field such as that from a recording head, Co tip gives a well contrasted and unsaturated image. For a weak field from a recorded medium, FeCo tip offers a sensitive image. The thickness of the coated tip also affects the images. We studied three different types of tip that are coated with FeCo (about 20 nm, 300 nm, and 2 /spl mu/m in thickness) by observing a longitudinal recorded medium to compare their sensitivity and resolution. The finest image was obtained with a 300 nm coated tip. As a further study, we demonstrated the utility of magnetotactic bacteria to characterize the magnetic structure of a MFM tip apex.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Study of nanocomposites prepared by melt blending TPU and montmorillonite (2008)

Abstract The intercalated thermoplastic polyurethane (TPU)/montmorillonite (MMT) nanocomposites were prepared by melt blending TPU and organic octadecylammonium‐treated MMT (ODA‐MMT) at 150–155°C for 10 min. Compared with those of TPU/montmorillonite composites, the interface interaction and dispersion of TPU/ODA‐MMT nanocomposites were improved remarkably. The tensile strength and tear strength of the TPU/ODA‐MMT nanocomposites were higher than those of pure TPU, and the MMT platelets dispersed on the nanometer scale in TPU matrix had reinforce effect. Due to the “labyrinth” effect of the MMT platelets dispersed on the nanometer scale in the TPU matrix caused by the eximious barrier and strong interaction between the MMT platelets and TPU, the temperature of initial weight loss of the TPU/ODA‐MMT nanocomposites was higher than that of pure TPU and TPU/MMT composites in the second thermodegradation step. POLYM. COMPOS., 2008. © 2008 Society of Plastics Engineers
Structure of the gluABCD cluster encoding the glutamate uptake system of Corynebacterium glutamicum (1995)

To assess the mechanism and function of the glutamate uptake system of gram-positive Corynebacterium glutamicum, a mutant deficient in glutamate uptake was isolated and was then used to isolate a DNA fragment restoring this deficiency. In a low-copy-number vector, this fragment resulted in an increased glutamate uptake rate of 4.9 nmol/min/mg (wild type, 1.5 nmol/min/mg). In addition, carbon source-dependent regulation of the glutamate uptake system was determined with the fragment, showing that the entire structures required for expression and control reside on the fragment isolated. Sequencing of 3,977 bp revealed the presence of a four-gene cluster (gluABCD) with deduced polypeptide sequences characteristic of a nucleotide-binding protein (GluA), a periplasmic binding protein (GluB), and integral membrane proteins (GluC and GluD), identifying the glutamate transporter as a binding protein-dependent system (ABC transporter). This identification was confirmed by the kinetic characteristics obtained for cells grown in the presence of globomycin, which exhibited an increased Km of 1,400 microM (without globomycin, the Km was 1.5 microM) but a nearly unaltered maximum velocity. By applying gene-directed mutagenesis, a strain with the entire cluster deleted was constructed. With this mutant, the glutamate uptake rate was reduced from 1.4 to less than 0.1 nmol/min/mg, which is proof that this system is the only relevant one for glutamate uptake. With this strain, the glutamate excretion rate was unaffected (18 nmol/min/mg), showing that no component of gluABCD is involved in export but rather that a specific machinery functions for the latter purpose.
Genetic manipulation of stationary-phase genes to enhance recombinant protein production inEscherichia coli (1996)

Genetic manipulation of the host strain, by which cell physiology could be modulated, was exploited to enhance recombinant protein production in Escherichia coli. The effects of an inactivated stationary-phase gene (rmf or katF) on recombinant protein production in strains with two different expression systems (the pH-inducible and the lac promoters) were investigated. An improvement of recombinant protein production in the katF mutant at low growth rates was observed for both expression systems. A fourfold and a 30% increase in the volumetric recombinant protein activity were observed for the pH-inducible and the lac promoter system, respectively. The effect of the rmf mutation, on the other hand, depends on the expression system. A twofold increase in the volumetric recombinant protein activity was found for the pH-inducible promoter system, but there was no improvement for the lac promoter system. Improvement in culture performance for slow-growing cultures may have an impact on the design strategy of the host/vector system used in fed-batch cultures, where the specific growth rate is usually slow. The information may also be useful for developing optimal host/vector gene expression systems for recombinant protein production.
Association of Interferon‐ and Transforming Growth Factor β–Regulated Genes and Macrophage Activation With Systemic Sclerosis–Related Progressive Lung Fibrosis (2013)

These results highlight major pathogenic pathways relevant to progressive pulmonary fibrosis in SSc-related ILD: macrophage emigration and activation, and up-regulated expression of TGFβ- and IFN-regulated genes.
HandSeg: An Automatically Labeled Dataset for Hand Segmentation from\n Depth Images (2017)

We propose an automatic method for generating high-quality annotations for\ndepth-based hand segmentation, and introduce a large-scale hand segmentation\ndataset. Existing datasets are typically limited to a single hand. By\nexploiting the visual cues given by an RGBD sensor and a pair of colored\ngloves, we automatically generate dense annotations for two hand segmentation.\nThis lowers the cost/complexity of creating high quality datasets, and makes it\neasy to expand the dataset in the future. We further show that existing\ndatasets, even with data augmentation, are not sufficient to train a hand\nsegmentation algorithm that can distinguish two hands. Source and datasets will\nbe made publicly available.\n
HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses. (2013)

HMPL-004 inhibits the development of chronic colitis by affecting early T-cell proliferation, differentiation, and TH(1)/TH(17) responses in a T-cell-driven model of colitis, presenting a unique mechanism of action. Our data suggest that HMPL-004 could be an attractive herbal therapeutic for inflammatory bowel disease.
Physico-Chemical Properties and Combustion Characteristics of New High-Energy-Density Caged Hydrocarbon Compounds (1998)

Abstract A new class of pentacyclic hydrocarbon compounds with high-energy/high density have been synthesized to be used as fuels or fuel additives, with the expectation that their inclusion in the fuel mixture will result in a net increase in volumetric efficiency of the current generation of powerplants. These compounds exhibit high density and contain a moderate amount of strain energy which contributes to the energy output during combustion. Through direct measurements, melting and boiling points, specific heats and latent heats of fusion were determined. Droplet combustion experiments with binary solutions of solid high-energy fuels in kerosene indicated increased effervescence and higher heat output. The liquid high-energy-density formulations exhibited microexplosive combustion behavior. Keywords: High-energy-density hydrocarbons Additional informationNotes on contributorsC. SEGAL Corresponding author.
Modeling Resilience in Electrical Distribution Networks (2019)

Electrical distribution networks deliver a fundamental service to citizens. However, they are still highly vulnerable to natural hazards as well as to cyberattacks; therefore, additional commitment and investments are needed to foster their resilience. Toward that, this paper presents and proposes the use of a complex simulation model, called reconfiguration simulator (RecSIM), enabling to evaluate the effectiveness of resilience enhancement strategies for electric distribution networks and the required resources to implement them. The focus is, in particular, on one specific attribute of resilience, namely, the readiness, i.e., the promptness and efficiency to recover the service functionality after a crisis event by managing and deploying the available resources rapidly and effectively. RecSIM allows estimating how and to what extent technological, topological, and management issues might improve electrical distribution networks’ functionality after the occurrence of accidental faults, accounting for interdependency issues and reconfiguration possibilities. The viability of implementing RecSIM on a real and large urban network is showcased in the paper with reference to the study case of the electrical distribution network (EDN) of Rome city.
Phase behavior in serial and parallel applications (2012)

It is well known that most serial programs exhibit time varying behavior, for example, alternating between memory- and compute-bound phases. However, most research into program phase behavior has focused on the serial SPEC benchmark suite, with little investigations into large scale phase behavior in parallel applications. In this study we compare and examine the time-varying behavior of the SPEC2006 (serial) and the PARSEC 2.1 (parallel) benchmarks suites, and investigate the program phase behavior found in parallel applications with different parallelization models. To this end, we extend a general purpose runtime phase desection library to handle parallel applications. Our results reveal that serial applications have significantly more program phases (2.4x) with larger variation in CPI (1.5x) compared to parallel applications. While the number of phases are fewer in parallel applications, there still exists interesting phase behavior. In particular, we find that data-parallel applications have shorter phases with more threads. This makes phase-guided runtime optimizations (e.g., dynamic voltage frequency scaling) less attractive as the number of threads grows. Meaning it is much more difficult to exploit runtime optimizations in parallel applications.
Correlation between Scattering Properties of Silver Particle Arrays and Fluorescence Enhancement (2008)

We report on the nanofabrication of patterned silver particle arrays using electron-beam lithography and the evaluation of their optical properties using backscattering and fluorescence spectroscopy. The silver particles varied in size from 100 to 250 nm and were in the shape of circles, squares, and triangles. Three inter-particle separations, 40, 65, and 90 nm as measured from the side of one particle to the side of the next particle, were used. We observed distinctive patterns of backscattering and fluorescence intensity depending on the particle size, inter-particle spacing, and excitation/emission wavelength used. Our approach allows for a study of the correlation between the backscattering intensities and fluorescence enhancement of silver particle arrays, which can be used to optimize the arrays for multi-fluorophore configuration for advanced sensing designs.
Colloidal Plasmonic Titanium Nitride Nanoparticles: Properties and Applications (2015)

Abstract Optical properties of colloidal plasmonic titanium nitride nanoparticles are examined with an eye on their photothermal and photocatalytic applications via transmission electron microscopy and optical transmittance measurements. Single crystal titanium nitride cubic nanoparticles with an average size of 50 nm, which was found to be the optimum size for cellular uptake with gold nanoparticles [1], exhibit plasmon resonance in the biological transparency window and demonstrate a high absorption efficiency. A self‐passivating native oxide at the surface of the nanoparticles provides an additional degree of freedom for surface functionalization. The titanium oxide shell surrounding the plasmonic core can create new opportunities for photocatalytic applications.