gebhart/patrepeval huggingface dataset:
Supramolecular Liquid-Crystalline Networks Built by Self-Assembly of Multifunctional Hydrogen-Bonding Molecules (1996)

Supramolecular liquid-crystalline networks have been prepared by self-assembly of multifunctional H-bond donor and acceptor molecules through the formation of intermolecular hydrogen bonds. Two tricarboxylic acids, 1,3,5-tris(2-(2-(4-carboxyphenoxy)ethoxy)ethoxy)benzene (1) and 3,4-bis(2-(2-(4-carboxyphenoxy)ethoxy)ethoxy)benzoic acid (2), have been synthesized for the use as trifunctional H-bond donors. These trifunctional H-bond donors have been complexed with bifunctional H-bond acceptors, such as 4,4‘-bipyridine (3), 1,2-bis(4-pyridyl)ethane (4), trans-1,2-bis(4-pyridyl)ethylene (5), and bis(2-(2-(4-(2-(4-pyridyl)ethenyl)phenoxy)ethoxy)ethyl) ether (6), maintaining a 1:1 donor/acceptor group stoichiometry. All individual components are nonmesogenic. Self-assembly of these multifunctional compounds results in the formation of liquid-crystalline network structures. For example, the H-bonded complex 1/5 shows a smectic A phase from 176 to 156 °C, while 2/5 exhibits a nematic phase between 200 and 87 °C on cooling. This behavior is attributed to the dynamics of the hydrogen bonds. These results suggest that the trifunctional H-bond donors adopt linear conformations that induce calamitic mesomorphic behavior with bifunctional H-bond acceptors.
Dopamine D3Receptors Expressed by All Mesencephalic Dopamine Neurons (2000)

A polyclonal antibody was generated using synthetic peptides designed in a specific sequence of the rat D(3) receptor (D(3)R). Using transfected cells expressing recombinant D(3)R, but not D(2) receptor, this antibody labeled 45-80 kDa species in Western blot analysis, immunoprecipitated a soluble fraction of [(125)I]iodosulpride binding, and generated immunofluorescence, mainly in the cytoplasmic perinuclear region of the cells. In rat brain, the distribution of immunoreactivity matched that of D(3)R binding, revealed using [(125)I]R(+)trans-7-hydroxy-2-[N-propyl-N-(3'-iodo-2'-propenyl)amino] tetralin ([(125)I]7-trans-OH-PIPAT), with dense signals in the islands of Calleja and mammillary bodies, and moderate to low signals in the shell of nucleus accumbens (AccSh), frontoparietal cortex, substantia nigra (SN), ventral tegmental area (VTA) and lobules 9 and 10 of the cerebellum. Very low or no signals could be detected in other rat brain regions, including dorsal striatum, or in D(3)R-deficient mouse brain. Labeling of perikarya of AccSh and SN/VTA appeared with a characteristic punctuate distribution, mostly at the plasma membrane where it was not associated with synaptic boutons, as revealed by synaptophysin immunoreactivity. In SN/VTA, D(3)R immunoreactivity was found on afferent terminals, arising from AccSh, in which destruction of intrinsic neurons by kainate infusions produced a loss of D(3)R binding in both AccSh and SN/VTA. D(3)R-immunoreactivity was also found in all tyrosine hydroxylase (TH)-positive neurons observed in SN, VTA and A8 retrorubral fields, where it could represent D(3) autoreceptors controlling dopamine neuron activities, in agreement with the elevated dopamine extracellular levels in projection areas of these neurons found in D(3)R-deficient mice.
Elevation Of Striatal Interleukin‐6 and Serum Corticosterone Contents In Mptp‐Treated Mice (1999)

1. Changes in the content of striatal interleukins (IL-1 beta and IL-6) and serum corticosterone in relation to deterioration of the dopaminergic system induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; a dopaminergic neurotoxin; 20 mg/kg i.p., four administrations/12 h) in C57BL/6J mice were investigated. 2. Striatal dopamine, IL-1 beta, IL-6 and serum corticosterone were measured on days 1 and 7 post-MPTP. 3. Dopamine depletion was more severe on day 7 than on day 1 post-treatment. 4. Increases in IL-6 were observed on days 1 and 7 post-MPTP. The increase in striatal IL-6 content varied with the extent of dopamine depletion, although the IL-1 beta concentration remained unchanged compared with control values on days 1 and 7 post-treatment. 5. Serum corticosterone was not different from control on day 1 post-MPTP. However, marked increases in the serum corticosterone were observed on day 7 post-treatment. 6. These results suggest that changes in striatal IL-6 and serum corticosterone are closely associated with the severity of MPTP-induced dopaminergic degeneration.
Search for R-parity-violating supersymmetric particles in multi-jet final states produced in p–p collisions at s=13 TeV using the ATLAS detector at the LHC (2018)

Results of a search for gluino pair production with subsequent R-parity-violating decays to quarks are presented. This search uses 36.1 fb -1 of data collected by the ATLAS detector in proton-proton collisions with a centre-of-mass energy of s = 13 TeV at the LHC. The analysis is performed using requirements on the number of jets and the number of jets tagged as containing a b-hadron as well as a topological observable formed by the scalar sum of masses of large-radius jets in the event. No significant excess above the expected Standard Model background is observed. Limits are set on the production of gluinos in models with the R-parity-violating decays of either the gluino itself (direct decay) or the neutralino produced in the R-parity-conserving gluino decay (cascade decay). In the gluino cascade decay model, gluino masses below 1850 GeV are excluded for 1000 GeV neutralino mass. For the gluino direct decay model, the 95% confidence level upper limit on the cross section times branching ratio varies between 0.80 fb at m g = 900 GeV and 0.011 fb at m g = 1800 GeV.
Multiple allogeneic progenitors in combination function as a unit to support early transient hematopoiesis in transplantation (2016)

Cord blood (CB) is a valuable donor source in hematopoietic cell transplantation. However, the initial time to engraftment in CB transplantation (CBT) is often delayed because of low graft cell numbers. This limits the use of CB. To overcome this cell dose barrier, we modeled an insufficient dose CBT setting in lethally irradiated mice and then added hematopoietic stem/progenitor cells (HSCs/HPCs; HSPCs) derived from four mouse allogeneic strains. The mixture of HSPCs rescued recipients and significantly accelerated hematopoietic recovery. Including T cells from one strain favored single-donor chimerism through graft versus graft reactions, with early hematopoietic recovery unaffected. Furthermore, using clinically relevant procedures, we successfully isolated a mixture of CD34(+) cells from multiple frozen CB units at one time regardless of HLA-type disparities. These CD34(+) cells in combination proved transplantable into immunodeficient mice. This work provides proof of concept that when circumstances require support of hematopoiesis, combined multiple units of allogeneic HSPCs are capable of early hematopoietic reconstitution while allowing single-donor hematopoiesis by a principal graft.
Turbulent Combustion Modeling Using Flamelet-Generated Manifolds for Gas Turbine Applications in OpenFOAM (2014)

The continuous interest in reducing pollutions and developing both an efficient and clean combustion system require large attention in the design requirements, especially when related to industrial gas turbine application. Although in recent years the advancements in modelling have increased dramatically, combustion still needs a huge computational effort. The Flamelet-Generated Manifolds (FGM) method is considered a suitable solution with an accuracy that can be comparable with detailed chemistry simulations results. The full combustion system can be described by few controlling variables while the chemical details are stored in a database (manifold) as function of controlling variables. Transport equations are solved for the Navier-Stokes system and the controlling variables. The detailed chemistry code Chem1D is used to create the manifolds. Turbulence can be modeled using a PDF approach for the subgrid modeling of the chemistry terms. The OpenFOAM open source CFD package is used as CFD tool for the simulations. The aim of this work is to demonstrate the usage of FGM with OpenFOAM and figure out the status of the implementation. To achieve this goal, the work employs as test case a confined lean jet flame is used. For the case presented, an extensive experimental data set exist, including PIV and Raman data. Results are further compared with traditional methods, while FGM method might be easily extended to other scenarios.
Solid Liquid Inter-Diffusion bonding at low temperature (2014)

Solid Liquid Inter-Diffusion (SLID) bonding using the systems Cu/Ga and Au/In have been investigated regarding the bonding parameters and their influence on shear strength. Especially temperature dependence and composition of interface have been focused on.
Hydrodynamic behaviour of several types of fluidized bed bioreactor used in a bioartificial liver. (2005)

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Deconvolution and propagation metrics of cardiac electrograms (2002)

Available metrics of cardiac electrograms are not considered to be adequate for activation time determination. The authors hypothesize that a deconvolution, which fits a modeled electrogram to an observed electrogram, is possible and would provide useful metrics of observed electrograms. They developed an algorithm which fits a uniform wave with constant velocity passing under the electrode. Activation time estimates were robust for fractionated electrograms, indicating potential clinical utility.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Demonstration of polarization-independent resonant subwavelength grating filter arrays (2010)

We demonstrate a two-dimensional (2D) polarization-independent resonant subwavelength grating (RSG) in a filter array. RSGs, also called guided mode resonant filters, are traditionally one-dimensional gratings; however, this leads to TE and TM resonances at different wavelengths and with different spectral shape. A 2D grating can remove the polarization dependence at normal incidence, while maintaining the desirable RSG properties of high reflectivity, narrow passband, and low sidebands without ripple. We designed and fabricated 2D gratings with near-identical responses for both polarizations at normal incidence in the telecommunication band. Ninety percent reflectivity is achieved at the resonant wavelengths.
Assessing the effectiveness of automated service composition (2016)

Service Composition is an important feature of Service Oriented Computing, yet it remains mostly a manual process. Given the dynamic and decentralized nature of services, manual composition is a complex undertaking. Proposals to automate this process exist, but suffer from practical problems that hinder their implementation. In this paper, we introduce a pragmatic approach where we reverse engineer a service composition repository to obtain the necessary information for automated solutions to work. We then evaluate the quality of the automated compositions based on their similarity to the ones written manually. A classic planning algorithm was adapted in order to generate solutions closer to those expected by developers. The use of classical planning tools is too time-consuming for agile development scenarios. A simplified, tailored implementation can be orders of magnitude faster than a generic planner, which suggests that expressive power may need to be sacrificed in favor of usability. Our evaluation showed that ensuring the adherence of the solution to the initial specification by enforcing the use of all input parameters was capable of significantly increasing the quality of the solutions. It is possible to increase the quality of automated composition by applying planning algorithms specially crafted for the service composition task. Comparisons with automated planning tools highlight the effectiveness of our proposal.
Manufacturing and Tribological Investigation of Hot Micro-Coined Lubrication Pockets (2014)

Friction and wear of lubricated machine elements can be reduced by the introduction of lubrication pockets produced by surface texturing. Different manufacturing methods can be taken into consideration whereas a forming process offers the possibility for mass production. Hot micro coining is a forming process, which allows manufacturing of surface textures with different shapes and dimensions into a flat and deformable material, e.g. seals made of steel. In this work hemispherical and ellipsoid pockets with a maximum depth of 100 µm have been embossed into stainless steel (AISI 304). To ensure that the used process parameters will not lead to tool damage, Finite Element simulations were performed and experimentally verified. First tribological experiments were conducted on a ball-on-disk tribometer in order to study the tribological properties of hemispherical structures with pockets depths of 50 and 100 µm. Different sliding velocities were applied to study the coefficient of friction and wear volume for different lubrication conditions. A comparison between coined and not‑coined specimens demonstrates that the micro coined surface textures lead to a significant reduction in the wear volume at boundary and mixed lubrication conditions.
ChemInform Abstract: Organocatalytic Synthesis of β‐Alkylaspartates via β‐Lactone Ring Opening. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Monolithically Integrated InGaAs Nanowires on 3D Structured Silicon-on-Insulator as a New Platform for Full Optical Links (2016)

Monolithically integrated III-V semiconductors on a silicon-on-insulator (SOI) platform can be used as a building block for energy-efficient on-chip optical links. Epitaxial growth of III-V semiconductors on silicon, however, has been challenged by the large mismatches in lattice constants and thermal expansion coefficients between epitaxial layers and silicon substrates. Here, we demonstrate for the first time the monolithic integration of InGaAs nanowires on the SOI platform and its feasibility for photonics and optoelectronic applications. InGaAs nanowires are grown not only on a planar SOI layer but also on a 3D structured SOI layer by catalyst-free metal-organic chemical vapor deposition. The precise positioning of nanowires on 3D structures, including waveguides and gratings, reveals the versatility and practicality of the proposed platform. Photoluminescence measurements exhibit that the composition of ternary InGaAs nanowires grown on the SOI layer has wide tunability covering all telecommunication wavelengths from 1.2 to 1.8 μm. We also show that the emission from an optically pumped single nanowire is effectively coupled and transmitted through an SOI waveguide, explicitly showing that this work lays the foundation for a new platform toward energy-efficient optical links.
Nanotechnologies in portable device energy and power (2010)

Novel energy storage solutions need flexible, stretchable and transparent energy storage solutions to enable Morph and similar futuristic concepts. Nanotechnologies, like growth of carbon nanotubes (CNT) on different conductive substrates and assembly of such structures in battery-supercapacitor electrodes can yield to remarkable increase in power density and energy. Portable consumer applications need also to be low cost and have fast or scalable process for manufacturing. Futuristic concepts urge drastically enhanced power and energy density compared to evolutionary route - current Li-ion battery development has been only 6-9% yearly increase with conventional development of more conductive cathodes and enhanced conduction electrolyte solutions.
Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo (2006)

Activation of JAK2 by chromosomal translocation or point mutation is a recurrent event in hematopoietic malignancies, including acute leukemias and myeloproliferative disorders. Although the effects of activated JAK2 signaling have been examined in cell lines and murine models, the functional consequences of deregulated JAK2 in the context of human hematopoietic cells are currently unknown. Here we report that expression of TEL-JAK2, a constitutively active variant of the JAK2 kinase, in lineage-depleted human umbilical cord blood cells results in erythropoietin-independent erythroid differentiation in vitro and induces the rapid development of myelofibrosis in an in vivo NOD/SCID xenotransplantation assay. These studies provide functional evidence that activated JAK2 signaling in primitive human hematopoietic cells is sufficient to drive key processes implicated in the pathophysiology of polycythemia vera and idiopathic myelofibrosis. Furthermore, they describe an in vivo model of myelofibrosis initiated with primary cells, highlighting the utility of the NOD/SCID xenotransplant system for the development of experimental models of human hematopoietic malignancies.
Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects (2011)

Topoisomerase I inhibitors down-regulate HIF-1α leading to tumor growth inhibition, but only while maintaining sustained levels of drug exposure. EZN-2208, a multi-arm 40 kDa pegylated, releasable SN38-drug conjugate, provides higher, longer lasting exposure of tumors to SN38 in contrast to SN38 that is released from CPT-11. EZN-2208 also consistently has greater antitumor activity than CPT-11 in a variety of solid and hematological tumor models. In this report, the ability of PEG-SN38 to down-regulate HIF-1α and its downstream targets, in a more potent, sustained manner compared with CPT-11 was examined. To do so, U251 glioma xenografts that stably expressed a hypoxia response element-dependent luciferase reporter gene were implanted in mice. After treatment it was found that EZN-2208 induced potent, sustained HIF-1α down-regulation (37% at 48 h and 83% at 120 h) in the tumors, whereas CPT-11 caused only minor, transient HIF-1α down-regulation. In addition, EZN-2208 down-regulated mRNA levels of HIF-1α targeted genes (MMP2, VEGF1, Glut1, Glut3 and TGFβ1). Further, western blot analyses of xenograft tumors demonstrated that EZN-2208 had significantly more effect than CPT-11 in down-regulating HIF-1α, VEGF, Glut1 and MMP2 protein levels. Significant down-regulation of HIF-1α and VEGF proteins translated to EZN-2208's superior anti-angiogenic activity compared with CPT-11, confirmed by microvessel density reduction in a chorioallantoic membrane assay and in CD-31 immunohistochemistry studies. Additional studies done with matrigel implants devoid of tumor cells show that EZN-2208 significantly inhibits angiogenesis while CPT-11 has little or no effect. It is concluded that the superior antitumor activity of EZN-2208 compared with CPT-11 is attributed, in part, to an anti-angiogenic effect. Ongoing clinical Phase I and Phase II studies will assess safety and efficacy of EZN-2208.
Intraocular Pressure Course During the Femtosecond Laser-Assisted Cataract Surgery in Porcine Cadaver Eyes (2017)

The present study reveals significant IOP increases during FLACS procedures carried out using the Catalys system.
AntMonitor: A System for On-Device Mobile Network Monitoring and its Applications (2016)

In this paper, we present a complete system for on-device passive monitoring, collection, and analysis of fine grained, large-scale packet measurements from mobile devices. First, we describe the design and implementation of AntMonitor as a userspace mobile app based on a VPN-service but only on the device (without the need to route through a remote VPN server) and using only the minimum resources required. We evaluate our prototype and show that it significantly outperforms prior state-of-the-art approaches: it achieves throughput of over 90 Mbps downlink and 65 Mbps uplink, which is 2x and 8x faster than mobile-only baselines and is 94% of the throughput without VPN, while using 2-12x less energy. Second, we show that AntMonitor is uniquely positioned to serve as a platform for passive on-device mobile network monitoring and to enable a number of applications, including: (i) real-time detection and prevention of private information leakage from the device to the network; (ii) passive network performance monitoring; and (iii) application classification and user profiling. We showcase preliminary results from a pilot user study at a university campus.
Preconfiguring IP-Over-Optical Networks to Handle Router Failures and Unpredictable Traffic (2006)

We consider the realization of traffic-oblivious rout- ing in IP-over-Optical networks where routers are interconnected over a switched optical backbone. The traffic-oblivious routing we consider is a scheme where incoming traffic is first distributed in a preset manner to a set of intermediate nodes. The traffic is then routed from the intermediate nodes to the final destination. This splitting of the routing into two phases simplifies network configuration significantly. In implementing this scheme, the first and second phase paths are realized at the optical layer with router packet grooming at a single intermediate node only. Stud- ies like (13) indicate that IP routers are 200 times more unreliable than traditional carrier-grade switches and average 1219 minutes of down time per year. Given this unreliability of routers, we consider how two-phase routing in IP-over-Optical networks can be made resilient against router node failures. We propose two different schemes for provisioning the optical layer to handle router node failures - one that is failure node independent and static, and the other that is failure node dependent and dynamic. We develop linear programming formulations for both schemes and a fast combinatorial algorithm for the second scheme so as to maximize network throughput. In each case, we determine (i) the optimal distribution of traffic to various intermediate routers for both normal (no-failure) and failure conditions, and (ii) provisioning of optical layer circuits to provide the needed inter-router links. We evaluate the performance of the two router failure protection schemes (in terms of throughput) and compare it with that of unprotected routing.