gebhart/patrepeval huggingface dataset:
Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation (2018)

Allogeneic transplantation (allo-HCT) has led to the cure of HIV in one individual, raising the question of whether transplantation can eradicate the HIV reservoir. To test this, we here present a model of allo-HCT in SHIV-infected, cART-suppressed nonhuman primates. We infect rhesus macaques with SHIV-1157ipd3N4, suppress them with cART, then transplant them using MHC-haploidentical allogeneic donors during continuous cART. Transplant results in ~100% myeloid donor chimerism, and up to 100% T-cell chimerism. Between 9 and 47 days post-transplant, terminal analysis shows that while cell-associated SHIV DNA levels are reduced in the blood and in lymphoid organs post-transplant, the SHIV reservoir persists in multiple organs, including the brain. Sorting of donor-vs.-recipient cells reveals that this reservoir resides in recipient cells. Moreover, tetramer analysis indicates a lack of virus-specific donor immunity post-transplant during continuous cART. These results suggest that early post-transplant, allo-HCT is insufficient for recipient reservoir eradication despite high-level donor chimerism and GVHD.
Six-Month Performance of a 3-Dimensional Annuloplasty Ring for Repair of Functional Tricuspid Regurgitation (2018)

www.ClinicalTrials.gov, NCT01532921.
Direct Observation of Triplet State Emission of Single Molecules:  Single Molecule Phosphorescence Quenching of Metalloporphyrin and Organometallic Complexes by Molecular Oxygen and Their Quenching Rate Distributions (2003)

Single molecules are detected through the phosphorescence emission of their triplet states. Emission of the triplet states of single molecules of Pt octabutoxycarbonyl porphyrin (PtOBCP) and ruthenium(II)-tris-4,7-diphenyl-1,10-phenanthroline dichloride (Ru(dpp)(3)Cl(2)) is reported. The single molecule phosphorescence is very sensitive to molecular oxygen. Each molecule has its own characteristic quenching rate by oxygen, and the distribution of these rates is measured for (Ru(dpp)(3)Cl(2)) on a quartz surface. The large variance of this distribution is presumed to be caused by fluctuations in the pseudobimolecular rate coefficient and the local oxygen concentration. The possibility of creating a quantitative single oxygen molecule sensor is suggested.
Prognostic significance of DNA cytometry for adjuvant therapy response in pancreatic cancer (2015)

The DNA index/tumor grading constellation may serve as a helpful guide for personalized treatment recommendations for adjuvant therapy of patients with pancreatic adenocarcinoma.
Transurethral balloon dilation of the external urinary sphincter: effectiveness in spinal cord-injured men with detrusor-external urethral sphincter dyssynergia. (1993)

The authors investigated balloon dilation as a minimally invasive alternative to transurethral external sphincterotomy for the treatment of detrusor-external urethral sphincter dyssynergia (DESD). Seventeen spinal cord-injured men with voiding pressures greater than 60 cm H2O underwent balloon dilation of the external sphincter to 90 F at 4 atm of pressure for 10 minutes. The mean voiding pressures before and 12 months after dilation were 83 cm H2O +/- 35 and 37 cm H2O +/- 15, respectively (P = .008). There was a significant decrease in residual urine volume, from 163 mL +/- 162 to 68 mL +/- 59 (P = .05), whereas bladder capacity remained relatively unchanged at 253 mL +/- 181 and 230 mL +/- 97 (P = .30). Complications included one case of postoperative bleeding necessitating transfusion, two treatment failures, and one bulbous urethral stricture. Fourteen of the 17 patients (82%) now void without the aid of an indwelling catheter or alternative therapy. Balloon dilation has no detrimental effect on erectile function and may improve fertility.
Multimodal Indoor Localization: An Audio-Wireless-Based Approach (2010)

Location-based services on mobile devices have become a key element in today's wireless and mobile phone infrastructure, which due to their potential for precise personalization offer interesting opportunities for Semantic Computing. However, location information is mostly only available outdoors and current indoor localization schemes are not very accurate. In this paper, we therefore present a novel approach for indoor localization using multiple modalities of information that are easily available indoors on handheld devices. We use the microphones plus the various wireless signals that are sensed by smartphones to serve as input for a novel localization approach. Our proposed approach is computationally lightweight and, by making use of recent machine learning techniques for integrating modalities, achieves greater accuracy than current work in the area.
ChemInform Abstract: ORGANOSELENIUM CHEMISTRY. PREPARATION AND REACTIONS OF BENZENESELENENAMIDES (1976)

Abstract Aus den Selenyl‐Verbindungen (I) werden die Amide (II) hergestellt.
Ternary inorganic electrides with mixed bonding (2019)

A high-throughput screening based on first-principles calculations was performed to search for new ternary inorganic electrides. From the available materials database, we identified three new thermodynamically stable materials (${\mathrm{Li}}_{12}{\mathrm{Mg}}_{3}{\mathrm{Si}}_{4}, {\mathrm{NaBa}}_{2}\mathrm{O}$, and ${\mathrm{Ca}}_{5}{\mathrm{Ga}}_{2}{\mathrm{N}}_{4}$) as potential electrides made by main group elements, in addition to the well known mayenite based electride (C12A7:${e}^{\ensuremath{-}}$). Different from those conventional inorganic electrides in which the excess electrons play only the role of anions, the three new materials, resembling the electrides found in simple metals under high pressure, possess mixed ionic and metallic bonding. The interplay between two competing mechanisms, together with the different crystal packing motifs, gives rise to a variety of geometries in anionic electrons and rich physical phenomena such as ferromagnetism, superconductivity, and metal-insulator transition. Our finding here bridges the gap between electrides found at ambient and high-pressure conditions.
Efficient single-heterojunction Al/sub 0.27/Ga/sub 0.73/As/GaAs p-i-n photodiodes with 22-GHz bandwidths (1991)

A report is presented on the design, fabrication, testing, and modeling of single-heterojunction Al/sub 0.27/Ga/sub 0.73/As/Ga p-i-n photodiodes for use as components in optical receivers. The photodiodes are grown by molecular beam epitaxy and fabricated as 1100- mu m/sup 2/ mesa structures. At 5-V reverse bias and 850 nm, 100 fF of capacitance, 90 pA of leakage current, 73% external quantum efficiency, <2% reflectivity, and 22-GHz bandwidths are typically measured.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Figure 2 from Proteasome Inhibition Causes Regression of Leukemia and Abrogates BCR-ABL–Induced Evasion of Apoptosis in Part through Regulation of Forkhead Tumor Suppressors (2023)

Supplementary Figure 2 from Proteasome Inhibition Causes Regression of Leukemia and Abrogates BCR-ABL–Induced Evasion of Apoptosis in Part through Regulation of Forkhead Tumor Suppressors
Data from Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Patients with metastatic pancreatic ductal adenocarcinoma (PDAC) have an average survival of less than 1 year, underscoring the importance of evaluating novel targets with matched targeted agents. We recently identified that poly (ADP) ribose glycohydrolase (PARG) is a strong candidate target due to its dependence on the pro-oncogenic mRNA stability factor HuR (&lt;i&gt;ELAVL1&lt;/i&gt;). Here, we evaluated PARG as a target in PDAC models using both genetic silencing of PARG and established small-molecule PARG inhibitors (PARGi), PDDX-01/04. Homologous repair–deficient cells compared with homologous repair–proficient cells were more sensitive to PARGi &lt;i&gt;in vitro&lt;/i&gt;. &lt;i&gt;In vivo&lt;/i&gt;, silencing of PARG significantly decreased tumor growth. PARGi synergized with DNA-damaging agents (i.e., oxaliplatin and 5-fluorouracil), but not with PARPi therapy. Mechanistically, combined PARGi and oxaliplatin treatment led to persistence of detrimental PARylation, increased expression of cleaved caspase-3, and increased γH2AX foci. In summary, these data validate PARG as a relevant target in PDAC and establish current therapies that synergize with PARGi.&lt;/p&gt;Significance:&lt;p&gt;PARG is a potential target in pancreatic cancer as a single-agent anticancer therapy or in combination with current standard of care.&lt;/p&gt;&lt;/div&gt;
Nano-structured carbon-coated CuO hollow spheres as stable and high rate anodes for lithium-ion batteries (2013)

Carbon-coated CuO hollow spheres with a thin layer of CuO nanoparticles anchored to the outer carbon layer were synthesized using a one-step, fast, scalable, and low-cost aerosol spray pyrolysis method. The hollow spherical particles provide a capacity of 670 mA g−1 at 1 C and maintain the capacity for 300 cycles and 400 mA h g−1 at 50 C. This is the best performance for CuO anodes reported to date. The exceptional electrochemical performance is attributed to the unique architecture of the carbon-coated hollow structure.
The Judgement Formula of the Adhesion on the Circular Plate with Beams (2007)

The adhesion judgement formula of the mirror with clamped beams is derived by the theoretical and numerical calculation. In design phase of the MEMS structure, it is difficult to judge the structure adheres to the substrate or not except circle plates or beams, and the adhesion design is liable to become trial and error. We point to a mirror with clamped beams as an example of an adhesion problem of the complicated structures, and have tried to derive the adhesion jugdement formula of the mirror with clamped beams we can jugde the mirror adheres to the substrate or not by using the dimension of the mirror and the adhesion energy between the mirror and the substrate.
Activation of IP3 receptors by synthetic bisphosphate ligands (2009)

Ca(2+) release by d-myo-inositol 1,4,5-trisphosphate receptors (IP(3)Rs) is widely considered to require the vicinal 4,5-bisphosphate motif of IP(3), with P-5 and P-4 engaging the alpha and beta domains of the binding site; using synthesis and mutagenesis we show that the adenine of synthetic glyconucleotides, through an interaction with Arg504, can replace the interaction of either P-1 or P-5 with the alpha-domain producing, respectively, the most potent bisphosphate agonist yet synthesised and the first agonist of IP(3)R without a vicinal bisphosphate motif; this will stimulate new approaches to IP(3)R ligand design.
InGaAsP (1.3 μm) vertical-cavity lasers using GaAs/AlAs mirrors (1992)

We demonstrate room temperature optically pumped operation of a 1.3 μm vertical-cavity laser (VCSEL) on a GaAs substrate. The 1.3 μm InGaAsP/ InP double heterostructures (DHs) were fused to GaAs/AlAs mirrors at 650°C in hydrogen. The larger refractive index ratio of GaAs to AlAs makes these mirrors an attractive alternative to mirrors made of InP/InGaAsP. Also, current can be injected through the GaAs /AlAs mirror into the InP DH. The second mirror is made by depositing a Si/SiNx dielectric stack. The wafer is optically pumped by using a mode-locked Nd:YAG laser with an 80 MHz repetition rate and 80 ps pulses. The room temperature threshold was 20 mW for a 16 μm diameter input spot. The laser operated in a single longitudinal mode at 1.283 μm up to twice threshold.
Propagation and compression of high power parabolic pulses generated in a high gain Yb:doped fibre amplifier (2002)

Summary form only given. The amplification of ultrashort pulses to high powers in optical fiber amplifiers is usually associated with severe pulse distortion due to optical wave-breaking, limiting the usefulness of such amplifiers in ultrafast optics. For sufficiently high gain, however, an incident ultrashort pulse in a fiber amplifier with normal dispersion evolves into a a parabolic pulse which propagates in a wave-breaking free manner. Here, we report the first experimental generation and characterization of such parabolic pulses using frequency-resolved optical gating (FROG). The pulses retain their parabolic profile after self-similar propagation in standard fiber and are compressed to 70 fs pulses with 80 kW peak power.
ESTIMATION OF TRAFFIC FLOW PARAMETERS IN URBAN TRAFFIC NETWORKS (1977)

The basic problem addressed is the development of better software for the computer control of urban traffic. Previous research indicates that the computer software, and especially the filtering and prediction algorithm, is the limiting factor in computerized traffic control. Recently developed techniques for the filtering, prediction and control of point processes, the type of statistics that occur in traffic flow, are used to develop filtering and prediction algorithms to facilitate the development of traffic responsive urban traffic control systems.
Blocked Elements in 1-D and 2-D Arrays—Part I: Detection and Basic Compensation on Simulated and In Vivo Targets (2020)

During a transcostal ultrasound scan, ribs and other highly attenuating and/or reflective tissue structures can block parts of the array. Blocked elements tend to limit the acoustic window and impede visualization of structures of interest. Here, we demonstrate a method to detect blocked elements and we measure the loss of image quality they introduce in simulation and in vivo. We utilize a fullwave simulation tool and a clinical ultrasound scanner to obtain element signals from fully sampled matrix arrays during simulated and in vivo transcostal liver scans, respectively. The elements that were blocked by a rib showed lower average signal amplitude and lower average nearest-neighbor cross correlation than the elements in the remainder of the 2-D aperture. The growing receive-aperture B-mode images created from the element data indicate that the signals on blocked elements are dominated by noise and that turning them OFF has a potential to improve visibility of liver vasculature. Adding blocked elements to the growing receive apertures for five in vivo transcostal acquisitions resulted in average decrease in vessel contrast and contrast to noise ratio of 19% and 10%, respectively.
Greater likelihood of remission in rheumatoid arthritis patients treated earlier in the disease course: Results from the Consortium of Rheumatology Researchers of North America registry (2011)

Earlier treatment was associated with a greater likelihood of remission.
Catalytic α-Deracemization of Ketones Enabled by Photoredox Deprotonation and Enantioselective Protonation (2021)

This study reports the catalytic deracemization of ketones bearing stereocenters in the α-position in a single reaction via deprotonation, followed by enantioselective protonation. The principle of microscopic reversibility, which has previously rendered this strategy elusive, is overcome by a photoredox deprotonation through single electron transfer and subsequent hydrogen atom transfer (HAT). Specifically, the irradiation of racemic pyridylketones in the presence of a single photocatalyst and a tertiary amine provides nonracemic carbonyl compounds with up to 97% enantiomeric excess. The photocatalyst harvests the visible light, induces the redox process, and is responsible for the asymmetric induction, while the amine serves as a single electron donor, HAT reagent, and proton source. This conceptually simple light-driven strategy of coupling a photoredox deprotonation with a stereocontrolled protonation, in conjunction with an enrichment process, serves as a blueprint for other deracemizations of ubiquitous carbonyl compounds.
Insect Antimicrobial Peptides: Structures, Properties and Gene Regulation (2005)

Antimicrobial peptides (AMPs) are part of the armament that insects have developed to fight off pathogens. Insect AMPs are typically cationic and often made of less than 100 amino acid residues. Although their structures are diverse, most of the AMPs can be assigned to a limited number of families. The most common structures are represented by peptides assuming a alpha-helical conformation in organic solutions or disulfide-stabilized beta-sheets with or without alpha-helical domains present. The diverse activity spectrum of these peptides may indicate different modes of action. Genetic analysis in the Drosophila model evidenced that multiple signal transduction pathways are activating the genes coding AMPs.
Simple Fabrication Method of Conductive Polymeric Arrays by Using Direct Laser Interference Micro‐/Nanopatterning (2007)

Thin films of polyaniline (PANI) deposited onto different polymeric substrates are nanostructured by using “direct laser interference patterning” at room temperature and pressure in air atmosphere. Regular linelike arrays (see figure) with thicknesses up to 600 nm are fabricated and their activity is determined using different techniques. The structuring mechanisms of PANI supported in both polycarbonate and polyimide films are demonstrated using cross-sectional analyses performed with a dual-beam workstation.
Lightweight Attestation Scheme for Wireless Sensor Network (2014)

Wireless sensor networks (WSNs) have been deployed for several applications that use M2M communications. Malicious code propagation is considered a serious threat on WSNs. In this paper, we considere a simple, distributed remote attestation method for a WSN that does not require secret information, precise timing measurement, or a tamper-resistant device. Each node holds a value for the attestation of other nodes, and sensor nodes check the validity of each other's data. A sensor node terminates itself to prevent propagation of malicious code, when the sensor node finds a unexpected changes in stored program and data. We analyzed the probability of success in protecting the WSN against malicious code under random network models. The analyses confirmed the feasibility of the attestation scheme and we obtained a fundamental approach to finding an appropriate frequency for attestation.
The Aachen Miniaturized Heart‐Lung Machine—First Results in a Small Animal Model (2009)

Congenital heart surgery most often incorporates extracorporeal circulation. Due to foreign surface contact and the administration of foreign blood in many children, inflammatory response and hemolysis are important matters of debate. This is particularly an issue in premature and low birth-weight newborns. Taking these considerations into account, the Aachen miniaturized heart-lung machine (MiniHLM) with a total static priming volume of 102 mL (including tubing) was developed and tested in a small animal model. Fourteen female Chinchilla Bastard rabbits were operated on using two different kinds of circuits. In eight animals, a conventional HLM with Dideco Kids oxygenator and Stöckert roller pump (Sorin group, Milan, Italy) was used, and the Aachen MiniHLM was employed in six animals. Outcome parameters were hemolysis and blood gas analysis including lactate. The rabbits were anesthetized, and a standard median sternotomy was performed. The ascending aorta and the right atrium were cannulated. After initiating cardiopulmonary bypass, the aorta was cross-clamped, and cardiac arrest was induced by blood cardioplegia. Blood samples for hemolysis and blood gas analysis were drawn before, during, and after cardiopulmonary bypass. After 1 h aortic clamp time, all animals were weaned from cardiopulmonary bypass. Blood gas analysis revealed adequate oxygenation and perfusion during cardiopulmonary bypass, irrespective of the employed perfusion system. The use of the Aachen MiniHLM resulted in a statistically significant reduced decrease in fibrinogen during cardiopulmonary bypass. A trend revealing a reduced increase in free hemoglobin during bypass in the MiniHLM group could also be observed. This newly developed Aachen MiniHLM with low priming volume, reduced hemolysis, and excellent gas transfer (O(2) and CO(2)) may reduce circuit-induced complications during heart surgery in neonates.
PRIMED (2006)

Most existing distributed denial-of-service (DDoS) mitigation proposals are reactive in nature, i.e., they are deployed to limit the damage caused by attacks after they are detected. In contrast, we present PRIMED, a proactive approach to DDoS mitigation that allows users to specify to their ISP a priori their (dis)interest in receiving traffic from particular network entities. Our solution employs communities of interest (COIs) to capture the collective past behavior of remote network entities and uses them to predict future behavior. Specifically, ISPs construct a network-wide bad COI that contains network entities who exhibited unwanted behavior in the past, and per-customer good COIs containing remote network entities that have previously engaged in legitimate communication with the customer. Our system uses these derived sets together with customer-specific policies to proactively mitigate DDoS attacks using existing router mechanisms. Indeed, preliminary lab testing shows that our approach is deployable on modern edge router platforms without degrading packet forwarding performance. This implies that our approach offers DDoS protection at a truly massive scale, i.e., every customer access link. Simulation results show that our approach improves protection against 91--93% of actual DDoS attacks on real customers---providing complete protection against 38--53% of such attacks---while slightly increasing vulnerability in only 5--7% of attacks.
XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A (2015)

We have unveiled a new understanding of the role of eIF5A and IGF2BP1 in XPO1 inhibitor-mediated cell death and support their clinical development for the treatment of ovarian and other cancers. Our data also ascertain the combinations of XPO1 inhibitors with specific chemotherapy drugs for therapeutic trials.
Solid-Phase Extraction and HPLC Analysis of Methylparaben and Propylparaben in a Concentrated Antibiotic Suspension (2006)

An accurate and precise solid-phase extraction coupled with high performance liquid chromatography (SPE/HPLC) method developed for the quantification of antimicrobial preservatives (methylparaben and propylparaben) in oxytetracycline injectable suspension is described in this article. The SPE technique was necessary to quantify the preservatives since the high concentration of the drug and excipients was masking low levels of preservatives, making quantification difficult. This developed HPLC method was stability-indicating and found to be linear between 1.3 to 2.4 mg/mL for methylparaben and 0.15 to 0.27 mg/mL for propylparaben in this concentrated antibiotic suspension formulation. The extraction recoveries were 98.8-101.6%. System precision and sample extraction precision (RSD) were less than 1%.