gebhart/patrepeval huggingface dataset:
Children Hospitalized With Influenza During the 2007–8 Season: a Report from the Canadian Immunization Monitoring Program, Active (Impact) (2009)

benefits to the health of Canadian
ChemInform Abstract: THE REDUCTION OF OXYGEN ON TEFLON‐BONDED PEROVSKITE OXIDE ELECTRODES (1978)

Abstract Die elektrochemische Reduktion von O, an Teflon‐gebundenen Ndmg Sro‐5 C003 ‐Elektroden in 45proz. KOH wird als Funktion von Temp. (25‐80°C) und O 2 ‐Partialdruck cyclisch voltammetrisch sowie durch potentiostatische Impulsmessungen untersucht.
Fabrication of a 2.8 V high-performance aqueous flexible fiber-shaped asymmetric micro-supercapacitor based on MnO2/PEDOT:PSS-reduced graphene oxide nanocomposite grown on carbon fiber electrode (2020)

Flexible and lightweight fiber-shaped micro-supercapacitors have attracted tremendous attention as next-generation portable electronic devices, due to their high flexibility, tiny volume, and wearability.
Applying 89Zr-Transferrin To Study the Pharmacology of Inhibitors to BET Bromodomain Containing Proteins (2016)

Chromatin modifying proteins are attractive drug targets in oncology, given the fundamental reliance of cancer on altered transcriptional activity. Multiple transcription factors can be impacted downstream of primary target inhibition, thus making it challenging to understand the driving mechanism of action of pharmacologic inhibition of chromatin modifying proteins. This in turn makes it difficult to identify biomarkers predictive of response and pharmacodynamic tools to optimize drug dosing. In this report, we show that (89)Zr-transferrin, an imaging tool we developed to measure MYC activity in cancer, can be used to identify cancer models that respond to broad spectrum inhibitors of transcription primarily due to MYC inhibition. As a proof of concept, we studied inhibitors of BET bromodomain containing proteins, as they can impart antitumor effects in a MYC dependent or independent fashion. In vitro, we show that transferrin receptor biology is inhibited in multiple MYC positive models of prostate cancer and double hit lymphoma when MYC biology is impacted. Moreover, we show that bromodomain inhibition in one lymphoma model results in transferrin receptor expression changes large enough to be quantified with (89)Zr-transferrin and positron emission tomography (PET) in vivo. Collectively, these data further underscore the diagnostic utility of the relationship between MYC and transferrin in oncology, and provide the rationale to incorporate transferrin-based PET into early clinical trials with bromodomain inhibitors for the treatment of solid tumors.
Rosiglitizone treatment does not improve insulin sensitivity in mice with whole body CAP gene deletion (2006)

The cbl/CAP pathway, an insulin signaling cascade leading to glucose uptake, is sensitive to TZD treatment, suggesting an overlap with the PPAR family of nuclear receptors. We hypothesized that CAP gene deletion would prevent improvements in insulin sensitivity resulting from rosiglitizone (ROSI) treatment. METHODS: Male CAP knockout (CAP, N = 24) and wildtype (WT, N = 23) mice were maintained on normal chow (NC), high fat diet (HFD) or high fat diet and rosiglitizone (ROSI) for 4–8 weeks. Glucose tolerance and insulin sensitivity were assessed with glucose and insulin tolerance tests and euglycemic‐hyperinsulinemic clamp studies. RESULTS: ROSI treatment improved responses to both ip glucose and insulin in WT mice on HFD, but was without effect in CAP mice. Similarly, glucose disposal rate was improved by 42% in WT mice following ROSI treatment, with no improvement seen in the ROSI treated CAP mice (CAP NC: 83.9 ± 9.4, CAP HFD: 62.8 ± 12.0, and CAP ROSI: 61.7 ± 7.1 mg/kg/min). However, CAP deletion prevented weight gain in response ROSI treatment (WT ROSI: 44.3 ± 1.6 vs. CAP ROSI: 34.4 ± 1.8 g), and this appears to be due to the prevention of increased liver mass (liver mass increase; WT: 98% vs. CAP: 26%). CONCLUSION: PPAR activation and subsequent insulin sensitization by exogenous TZD treatment may indeed require CAP expression. Furthermore, the effects of TZD treatment on liver enlargement are dependent on CAP expression.
Abstract 9466: Recombinant Mitochondrial Transcriptional Factor A Protein Attenuates Pathological Remodeling in Cardiac Myocytes (2011)

Introduction: Mitochondrial transcriptional factor A (TFAM), a nucleoid protein of mitochondrial DNA (mtDNA), is essential not only for transcription and replication but also maintenance of mtDNA. We have previously reported that, in failing myocardium, TFAM expression and the myocardial mtDNA copy number were decreased. Moreover, in myocardial infarction, overexpression of TFAM attenuated the decrease in the mtDNA copy number, ameliorated cardiac remodeling, and markedly improved survival. Since exogenously-administrated recombinant TFAM protein has been shown to enter mitochondria in cultured cells, we examined our hypothesis that recombinant TFAM protein administration attenuates pathological remodeling in cardiac myocytes. Methods and Results: We prepared recombinant human TFAM including mitochondrial targeting signal by glutathione s-transferase fusion protein purification protocol. Recombinant TFAM was successfully recruited into mitochondria of rat neonatal cardiac myocytes, whereas TFAM without mitochondrial targeting signal was observed in nucleus. Treatment with TFAM increased the mtDNA copy number dose-dependently (100 nM: 1.8±0.1-folds), whereas it did not change morphology or population of mitochondria (electron microscopy). To elucidate the mechanism of TFAM on signaling pathways in cardiac hypertrophy, we investigated the effects of TFAM on the nuclear factor of activated T cell (NFAT) signaling, which is a major transcriptional factor regulating pathological hypertrophy and remodeling. TFAM totally abolished NFAT nuclear translocation induced by both angiotensin II (41±3% to 2±1%, p&lt;0.01) and endothelin-1 (43±3% to 3±1%, p&lt;0.01), suppressing respective NFAT transcriptional activity and NFAT-dependent gene expression. TFAM inhibited subsequent morphological hypertrophy of cardiac myocytes (angiotensin II: 1686±37 to 1167±20 μ m 2 , p&lt;0.01, and endothelin-1: 1759±44 to 1206±21 μ m 2 , p&lt;0.01). Conclusion: Recombinant TFAM increases the mtDNA copy number, and attenuates angiotensin II and endothelin-1-induced hypertrophy via inhibiting NFAT signaling. Recombinant TFAM would be an attractive, novel therapeutic strategy for cardiac hypertrophy and remodeling.
Performance and cross-crop resistance of Cry1F-maize selected Spodoptera frugiperda on transgenic Bt cotton: implications for resistance management (2016)

Transgenic crops producing Bacillus thuringiensis (Bt) proteins have become a primary tool in pest management. Due to the intensive use of Bt crops, resistance of the fall armyworm, Spodoptera frugiperda, to Cry1F maize has occurred in Puerto Rico, Brazil, and some areas of the southeastern U.S. The sustainability of Bt crops faces a great challenge because the Cry1F-maize resistant S. frugiperda may also infest other Bt crops in multiple cropping ecosystems. Here we examined the survival and plant injury of a S. frugiperda population selected with Cry1F maize on three single-gene and five pyramided Bt cotton products. Larvae of Cry1F-susceptible (SS), -heterozygous (RS), and -resistant (RR) genotypes of S. frugiperda were all susceptible to the pyramided cotton containing Cry1Ac/Cry2Ab, Cry1Ac/Cry1F/Vip3A, Cry1Ab/Cry2Ae, or Cry1Ab/Cry2Ae/Vip3A, and the single-gene Cry2Ae cotton. Pyramided cotton containing Cry1Ac/Cry1F was effective against SS and RS, but not for RR. These findings show that the Cry1F-maize selected S. frugiperda can cause cross-crop resistance to other Bt crops expressing similar insecticidal proteins. Resistance management and pest management programs that utilize diversify mortality factors must be implemented to ensure the sustainability of Bt crops. This is especially important in areas where resistance to single-gene Bt crops is already widespread.
Diet Modification Based on the Enhanced Recovery After Surgery Program (ERAS) in Patients Undergoing Laparoscopic Colorectal Resection (2018)

The enhanced recovery after surgery (ERAS) program aims to maximize the recovery of patients by minimizing pre- and postoperative complications and stress. The program recommends providing preoperative carbohydrate (CHO) supplements and starting an early postoperative diet to reduce the fasting duration. Based on these recommendations, we implemented preoperative CHO supplementation and initiated an early postoperative diet in patients undergoing laparoscopic colorectal resection. We observed 3 patients as follows: a non-ERAS case, preoperative ERAS case, and pre- and postoperative ERAS case. The preoperative well-being and compliance of patients improved after implementation of the ERAS program. Moreover, the length of hospital stay was reduced. Therefore, we consider that the ERAS program may be helpful for the recovery of patients undergoing laparoscopic colorectal resection.
In Vitro Responses of Tolerant and Susceptible Lines of Lotus corniculatus L. to 2,4‐D1 (1980)

A positive relationship was established between the in vivo and in vitro 2,4‐D [(2,4‐dichIorophenoxy) acetic acid] response of two lines of birdsfoot trefoil ( Lotus corniculatus L.). Callus cultures were initiated from a line selected for 2,4‐D tolerance in the field (T‐68), and from a susceptible cultivar ‘Leo.’ The response of the two callus lines was compared with 2,4‐D levels lower than the maintenance medium (&lt;1 mg/liter), on progressively higher levels (5, 10, 15, and 20 mg/liter), and on high levels (40 mg/liter) throughout seven subcultures. The Leo callus was more responsive to both decreased, and moderately increased levels of 2,4‐D. Growth of both callus cultures was severely inhibited at high levels of 2,4‐D. In vitro selection for 2,4‐D tolerance appears to be practicable in Lotus corniculatus L. Indications are that 2,4‐D conjugation is one possible mechanism for differential tolerance in this species.
A new objective quality metric for phase hologram processing (2021)

Abstract Because of its convenience and compatibility with various image processing techniques, digital image representation of holograms is generally used in digital holography, and thus, quality assessment of digital holograms is an essential issue. This study proposes a new objective quality metric for digital phase hologram image processing. The proposed metric is based on a newly defined phase distortion created by taking the 2 π periodicity of phase information into account. The experimental results show that the proposed metric correlates with reconstruction image quality better than the existing metric under random distortions and also works well with JPEG 2000 compression. It is expected to be broadly used in phase image processing and compression applications including phase holograms.
A novel concept for fast recovery diodes having junction charge extraction (JCE) regions (2002)

A novel concept for achievement of superior performance in modern fast power diodes is presented in this paper. The junction charge extraction diode (JCE) is based on the integration of low and high lifetime regions in a single structure using masked helium irradiation. This new technique enables us to achieve improved static and dynamic characteristics when compared to uniform and axial lifetime controlled diodes. Simulation and experimental results are presented in this paper to verify the new concept.
RNA Ligands That Distinguish Metabolite‐Induced Conformations in the TPP Riboswitch (2006)

Molecular diversity meets RNA conformation: In vitro selected RNA hairpins (red) bind to the thiM riboswitch of E. coli and are released upon addition of thiamine pyrophosphate (TPP; see scheme). These hairpins guide the identification of nucleotides that are important for riboswitch function. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z603166_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Modified Hankel Interaction Index Array for Input-Output Pairing with Improved Characteristics (2018)

In this study, a modified version of Hankel Interaction Index Array (HIIA) for control configuration selection is presented which can overcome some of its shortcomings, like e.g. scaling dependency, or not relating to closed loop system properties. Inspired by the relative gain array approach, the HIIA is reformulated in the relative gain thinking by considering the effect of closing loops. The ratio of the Hankel norm of the subsystems in closed and open loop are used to state a modified version of HIIA, which has improved characteristics compared to the original HIIA. Properties of the modified HIIA are discussed and benchmarked with established methods on three example cases.
Integration of Onboard Batteries and Supercapacitors Based on the Multi-Source Inverter for Light Rail Vehicles (2022)

Light rail vehicles with onboard energy storage systems have gained increasing interest due to higher efficiency and lower or null local emissions in catenary-less operation. Their traction circuit conventionally employs inverters to drive the traction motors and DC/DC converters to manage the onboard sources. Recently, the concept of multi-source inverter (MSI) was introduced for single-stage integration of AC loads and multiple DC sources without. This paper evaluates the feasibility and attractiveness of the MSI for single-stage integration of batteries and supercapacitors to the traction motors in a catenary-less tramway vehicle. The configuration of the MSI-based hybrid energy storage system is detailed. Numerical simulations are carried out to assess its performance over a typical driving cycle. Furthermore, the proposed architecture is compared to a standard configuration employing a DC/DC converter to control the supercapacitors, with focus on power losses and volumes of the converters and DC sources.
ChemInform Abstract: Introduction of Nitrogen Functionalities into (R)‐1‐Fluoro‐3‐(p‐ tolylsulfinyl)propan‐2‐one. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Rapid electro-optic control of the carrier-envelope-offset frequency for ultra-low noise frequency combs (2017)

We report on a novel electro-optic modulator that acts on the carrier-envelope-offset frequency of a femtosecond pulsed laser with negligible cross-talk to the position of the optical carrier modes. The fast response on the nanosecond time scale allows to stabilize the carrier-envelope-offset frequency with a bandwidth in excess of 1 MHz while not perturbing a potential independent stabilization of a carrier mode to an optical reference. Out-of-loop verification of both optical and CEO frequency suggests a sub-Hz stability for all (partially virtual) spectral comb lines between 0 Hz and 400 THz.
Spectral narrowing and tunability of a high-power diffraction-limited ns-pulsed OPO/OPA system using transversely-chirped and temperature-tuned volume Bragg gratings (2009)

We describe the design and performance of a high-peak-power, ns-pulsed, tunable OPO/OPA light source. The use of a volume Bragg grating output coupler in a 532-nm-pumped, singly-resonant KTP OPO provides stable, narrow-band (&lt; 2-cm<sup>-1</sup>) and frequency-tunable generation of light in the vicinity of 1 micron. Subsequent phase-coherent amplification of the signal-wave pulses in a single-pass, 532-nm-pumped KTP OPA provides &gt;20 dB gain (up to 15 mJ pulse energy and 3 MW peak power). One frequency-doubled unstable-resonator Nd:YAG laser provides pump light for both OPO and OPA. The amplified signal wave is single-pass frequency-doubled to the blue-green in non-critically-phase-matched LBO, and frequency-doubled to the ultraviolet in critically-phase-matched CLBO, with efficiencies exceeding 50% and 25%, respectively.
Joint Transmit and Receive Beamforming Design in Full-Duplex Integrated Sensing and Communications (2023)

Integrated sensing and communication (ISAC) has been envisioned as a solution to realize the sensing capability required for emerging applications in wireless networks. For a mono-static ISAC transceiver, as signal transmission durations are typically much longer than the radar echo round-trip times, the radar returns are drowned by the strong residual self interference (SI) from the transmitter, despite adopting sufficient SI cancellation techniques before digital domain - a phenomenon termed the echo-miss problem. A promising approach to tackle this problem involves the ISAC transceiver to be full-duplex (FD), and in this paper we jointly design the transmit and receive beamformers at the transceiver, transmit precoder at the uplink user, and receive combiner at the downlink user to simultaneously 1) maximize the uplink and downlink communication rate; 2) maximize the transmit and receive radar beampattern power at the target; and 3) suppress the residual SI. To solve this optimization problem, we proposed a penalty-based iterative algorithm. Numerical results illustrate that the proposed design can effectively achieve up to 60 dB digital-domain SI cancellation, a higher average sum-rate, and more accurate radar parameter estimation compared with previous ISAC FD studies.
A Systematic Review of the Quality and Utility of Observer-Based Instruments for Assessing Medical Professionalism (2018)

We identified 2 instruments with best psychometric properties, with 1 also showing acceptable utility for assessing professionalism in trainees. The P-MEX may be an option for program directors to adopt as an observer-based instrument for formative assessment of medical professionalism. Further studies of the 2 instruments to aggregate additional validity evidence is recommended, particularly in the domain of content validity before they are used in specific cultural settings and in summative assessments.
A stable covalent organic framework for photocatalytic carbon dioxide reduction (2019)

Photocatalytic conversion of CO<sub>2</sub> into fuels is an important challenge for clean energy research and has attracted considerable interest. Here we show that tethering molecular catalysts-a rhenium complex, [Re(bpy)(CO)<sub>3</sub>Cl]-together in the form of a crystalline covalent organic framework (COF) affords a heterogeneous photocatalyst with a strong visible light absorption, a high CO<sub>2</sub> binding affinity, and ultimately an improved catalytic performance over its homogeneous Re counterpart. The COF incorporates bipyridine sites, allowing for ligation of the Re complex, into a fully π-conjugated backbone that is chemically robust and promotes light-harvesting. A maximum rate of 1040 μmol g<sup>-1</sup> h<sup>-1</sup> for CO production with 81% selectivity was measured. CO production rates were further increased up to 1400 μmol g<sup>-1</sup> h<sup>-1</sup>, with an improved selectivity of 86%, when a photosensitizer was added. Addition of platinum resulted in production of syngas, hence, the co-formation of H<sub>2</sub> and CO, the chemical composition of which could be adjusted by varying the ratio of COF to platinum. An amorphous analog of the COF showed significantly lower CO production rates, suggesting that crystallinity of the COF is beneficial to its photocatalytic performance in CO<sub>2</sub> reduction.
STUDIES ON THE COUPLING RATES IN LIQUID‐PHASE PEPTIDE SYNTHESIS USING COMPETITION EXPERIMENTS (1979)

Competition experiments were carried out in order to determine relative reaction rates, Vrel, for the peptide-forming step. Using the liquid-phase method of peptide synthesis a model system was developed to investigate the influence of coupling method, amino component, derivatization and solvent upon Vrel. According to a standard procedure, Vrel for all 20 commonly occurring amino acids were established. A strong dependence of Vrel upon steric effects of the coupling components was found. The data obtained may serve as a guideline for optimizing the reaction conditions in peptide synthesis.
Magnetic Properties of LiNi0.33Mn0.33Co0.33 as Positive Electrode for Li-Ion Batteries (2007)

In this work, we studied the magnetic properties of LiNi0.33Mn0.33Co0.33O2 synthesized by wet chemistry via oxalate route. Measurements included the temperature dependence of the magnetic susceptibility, χm (T) and magnetization M(H). The influence of the synthesis conditions on the magnetic and electronic properties is presented and discussed. Analysis of magnetic data allows the determination of the cationic disorder, i.e. the concentration of Ni2+ ions in the 3a lithium sites.
Probing the environment along the protein import pathways in yeast mitochondria by site-specific photocrosslinking (1997)

Artificially aminoacylated suppressor tRNAs were used to introduce photoreactive amino acids into model mitochondrial precursor proteins to probe the environment along the protein import pathway. Amino acids with benzophenone side chains of various lengths [DL-2-amino-3-(p-benzoylphenyl)propanoic acid (1) and DL-2-amino-5-(p-benzoylphenyl)pentanoic acid (2)] were incorporated at specific sites throughout the cytochrome b2-dihydrofolate reductase fusion proteins, pb2(220)-DHFR and pb2 delta 19(220)-DHFR, which were destined for the intermembrane space and the matrix in mitochondria, respectively. In vitro import of pb2(220)-DHFR and pb2 delta 19(220)-DHFR bearing 1 or 2 into isolated yeast mitochondria was arrested so that the N terminus reached the intermembrane space or the matrix, respectively, while the DHFR domain remained at the mitochondrial surface. The matrix-targeted pb2 delta 19(220)-DHFR was photocrosslinked to Tom40 in the outer membrane, Tim44 in the inner membrane, and Ssc1p in the matrix, suggesting that the protein has an extended conformation in the import channels. On the other hand, incorporation of 2 at various positions in the 50-residue segment of intermembrane-space-targeted pb2(220)-DHFR gave photocrosslinks only to Tom40, suggesting that the segment is not in an extended conformation, but localized near Tom40. The N-terminal portion of pb2(220)-DHFR, but not pb2 delta 19(220)-DHFR, was photocrosslinked to an as-yet-unidentified mitochondrial component to generate a 95-kDa crosslinked product.