gebhart/patrepeval huggingface dataset:
Diarylamino functionalized pyrene derivatives for use in blue OLEDs and complex formation (2004)

Three new 2,2′-dipyridylamino functionalized pyrene derivatives, 1-pyrenyl-2,2′-dipyridylamine (1), 4-(1-pyrenyl)phenyl-2,2′-dipyridylamine (2), and 4-[4′-(1-pyrenyl)biphenyl]-2,2′-dipyridylamine (3) have been synthesized and fully characterized. For comparison of electronic properties, a diphenylamino functionalized molecule 4-[4′-(1-pyrenyl)biphenyl]diphenylamine (4) has also been synthesized. Compounds 1–4 are bright blue emitters in solution and in the solid state with λmax at ∼420–460 nm and a high emission efficiency in solution. All four compounds form amorphous glasses with Tg values of 66 °C, 79 °C, 165 °C, and 98 °C, respectively. The electronic properties of the four compounds were examined by spectroscopic methods, cyclic voltammetry and Gaussian 98 molecular orbital calculations. The utilities of this class of molecules in OLEDs have been demonstrated by EL devices of compounds 3 and 4, which showed that 3 can function as a bright blue emitter and an electron transport material in a double-layer device while 4 can function as a bright blue emitter and a hole transport molecule in a triple-layer device. The dipyridylamino functional group in molecules 1–3 are capable of chelating to metal ions such as Zn(II) as demonstrated by the synthesis and structure of the complex [2·(Zn(O2CCF3)2]2 (5). The binding of Zn(II) ions to the dipyridyl group causes a reduction of the emission efficiency of the ligand 2.
A deep learning system to diagnose the malignant potential of urothelial carcinoma cells in cytology specimens (2021)

The DLS could accurately screen UC cells and determine the malignant potential of tumors more accurately than classical cytology. The use of a DLS during cytopathology screening could help urologists plan therapeutic strategies, which, in turn, may be beneficial for patients.
Characterization of Symptomatic Hip Impingement in Butterfly Ice Hockey Goalies (2014)

Level IV, prognostic case series.
Multiple incidence angle SIR-B experiment over Argentina (1986)

The Shuttle Imaging Radar (SIR-B), the second synthetic aperture radar (SAR) to fly aboard a shuttle, was launched on October 5, 1984. One of the primary goals of the SIR-B experiment was to use multiple incidence angle radar images to distinguish different terrain types through the use of their characteristic backscatter curves. This goal was accomplished in several locations including the Chubut Province of southern Argentina. Four descending image acquisitions were collected providing a multiple incidence angle image set. The data were first used to assess stereo-radargrammetric techniques. A digital elevation model was produced using the optimum pair of multiple incidence angle images. This model was then used to determine the local incidence angle of each picture element to generate curves of relative brightness vs. incidence angle. Secondary image products were also generated using the multi-angle data. The results of this work indicate that: (1) various forest species and various structures of a single species may be discriminated using multiple incidence angle radar imagery, and (2) it is essential to consider the variation in backscatter due to a variable incidence angle when analyzing and comparing data collected at varying frequencies and polarizations.
An assessment of native tree susceptibility to the simulated aerial application of the herbicide flupropanate, for management of exotic unpalatable grasses. (2008)

Re-afforestation is a management tool for long term control of exotic unpalatable grasses. Grass control is required at tree planting to maintain tree vigour and establishment. Flupropanate is a widely used herbicide for managing unpalatable grasses. The impact of a simulated aerial application of flupropanate at the recommended rate (1.49 kg a.i. ha) and twice recommended rate (2.98 kg a.i. ha) on a native tree trial located in the Rowsley Valley at Glenmore was conducted between 2004 and 2006. Results show that flupropanate does impact on tree survival with approximately 1 in 40 seedlings dying at 1.49 kg a.i. ha and 1 in 20 dying at 2.98 kg a.i. ha. Flupropanate substantially reduced height of black wattle and caused obvious leaf shrivelling/leaf deformation. Flupropanate reduced the height of varnish wattle but did not appear to affect leaf health. Flupropanate did not affect tree heights or cause apparent leaf damage to grey box, yellow gum or drooping sheoak. The use of flupropanate for wide scale unpalatable grass control in the establishment of native tree re-afforestation is discussed.
Resistivity and Microstructure of Joint-Interface between YBa<SUB>2</SUB>Cu<SUB>3</SUB>O<SUB>7&minus;&delta;</SUB> and Indium Alloys (1992)

In order to improve contact resistance between high-Tc superconducting ceramics YBa2Cu3O7−δ and Indium or Indium alloys, interfacial microstructures of the contacts were studied with respect to contact resistance.YBa2Cu3O7−δ ceramics (YBCO) was prepared by a solid state reaction and sintering of the dry powders at 1223 K. The YBCO/Indium or YBCO/Indium alloy interface was made by soldering below 623 K under ultrasonic exciting loading. In the contact of YBCO/Indium, the microstructure and compounds near the interface were analyzed by SEM-EDX, TEM and XRD, and it was observed that the reacted layer at the interface consists of In2O3 and Ba-In oxides. It is thought that these compounds give a comparatively high contact resistivity of 10−6Ω·m2 order.Then, in order to make lower the contact resistivity, ten kinds of binary alloys with additives of Pb, Sn and Cd, etc. were used to join with YBCO. Among these alloys, the contact resistivity in the YBCO/In-Cd interfacial layer was very low which is about 10−9∼10−8Ω·m2. One of the compounds in this layer was identified as CdO. The resistivity of CdO was about 10−3Ω·m, much lower than that of In2O3. Therefore we considered that low contact resistance of the YBCO/In-Cd interface is due to the formation of CdO at the reacted layer.
Suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect by inhibiting histone deacetylation (2004)

Pro-inflammatory cytokines and the loss of gastrointestinal tract integrity contribute to acute graft-versus-host disease (GVHD) whereas the donor cytotoxic responses are critical for graft-versus-leukemia (GVL) preservation. Suberoylanilide hydroxamic acid (SAHA) is an anti-tumor agent that inhibits the activity of histone deacetylases (HDAC) and reduces the production of proinflammatory cytokines. Using a well characterized allogeneic murine BMT model B6 (H-2b) → B6D2F1 (H-2b/d) we studied the effects of HDAC inhibition by SAHA on acute GVHD. Recipients were transplanted with 2x10 6 donor T and 5x106 BM cells after13 GY TBI. Intra-peritoneal injections of 35 mg/kg/day of SAHA from days +3 to day +7 increased histone H3 acetylation in splenocytes harvested 7 days after BMT, confirming the inhibition of HDAC enzymes. SAHA treatment significantly reduced the serum levels of pro-inflammatory cytokines such as TNF-a, IL-1β and IFN-γ (P < 0.04) in the allogeneic recipients on day +7 after BMT. Intracytoplasmic staining by flow cytometry and RPA analysis of the host splenocytes on day +7 confirmed the decrease in the cytokine protein and mRNA. SAHA significantly improved the survival (P < 0.002) and reduced intestinal damage from GVHD of the allogeneic recipients . However SAHA did not suppress the donor T cell expansion in vivo and the proliferative and cytotoxic responses to host antigens in vitro measured 7 and 14 days after BMT. To test the effect of SAHA on GVL effects, recipients were injected with lethal doses of P815 (H-2d) tumor cells at the time of BMT. SAHA treatment resulted in significantly improved leukemia-free survival after allogeneic BMT (P < 0.05) whereas all the syngeneic BMT recipients of SAHA died of tumor ruling out direct anti-tumor effects of SAHA. Furthermore SAHA increased H3 acetylation in the splenocytes from both the syngeneic and allogeneic leukemic recipients on day +7, confirming that inhibition of HDAC enzymes alone is not sufficient for leukemia free survival in this system. We also tested the effect of SAHA in a second allogeneic BMT model (BALB/c → B6), where it also significantly improved survival (P < 0.001) and preserved GVL effects when recipient mice were injected with lethal doses of EL-4 (H-2b) tumor (P < 0.04). We conclude that HDAC inhibition regulates acute GVHD in these models and suggest that this class of pharmacologic agents may provide a novel strategy to reduce GVHD while maintaining the beneficial GVL effects.
Effect of Fuel Injection Pressure on a Heavy-Duty Diesel Engine Nonvolatile Particle Emission (2011)

The effects of the fuel injection pressure on a heavy-duty diesel engine exhaust particle emissions were studied. Nonvolatile particle size distributions and gaseous emissions were measured at steady-state engine conditions while the fuel injection pressure was changed. An increase in the injection pressure resulted in an increase in the nonvolatile nucleation mode (core) emission at medium and at high loads. At low loads, the core was not detected. Simultaneously, a decrease in soot mode number concentration and size and an increase in the soot mode distribution width were detected at all loads. Interestingly, the emission of the core was independent of the soot mode concentration at load conditions below 50%. Depending on engine load conditions, growth of the geometric mean diameter of the core mode was also detected with increasing injection pressure. The core mode emission and also the size of the mode increased with increasing NOx emission while the soot mode size and emission decreased simultaneously.
Supplemental Table S3 from Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future (2023)

&lt;p&gt;Supplemental Table S3&lt;/p&gt;
High quantum efficiency of semipolar GaInN/GaN quantum wells (2008)

Abstract The development of efficient GaInN/GaN based light emitting devices is hampered by built‐in electric fields. These fields, arising from piezoelectric and spontaneous polarization, separate electron and hole wavefunctions and reduce their spatial overlap. Therefore, the internal quantum efficiency is drastically reduced in the presence of built‐in fields. To decrease the detrimental influence of the polarization fields on quantum efficiency, growth on non‐ or semipolar crystal facets is conducted. We investigate samples containing quantum wells grown on the {1 $\bar 1$ 01} facet (tilt angle from (0001) is θ = 62°) of selectively grown GaN stripes and compare them to samples grown on the commonly used c plane. We experimentally determine direction and strength of built‐in polarization fields. These fields are used to compute overlap integrals and to estimate the internal quantum efficiency of semipolar quantum wells in comparison to polar and nonpolar ones. (© 2008 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Experimental evidence for the Si-Si bond model of the 7.6-eV band inSiO2glass (1991)

We have found a decrease in the intensity of the 7.6-eV band and the appearance of the Si-H band upon heating ${\mathrm{SiO}}_{2}$ glasses, which were prepared by a method involving processes of dehydration with ${\mathrm{Cl}}_{2}$ gas, in ${\mathrm{H}}_{2}$ gas. The absorption cross section of the 7.6-eV band evaluated from these changes is 7.5\ifmmode\times\else\texttimes\fi{}${10}^{\mathrm{\ensuremath{-}}17}$ ${\mathrm{cm}}^{2}$, which is close to that of a band centered at 7.56 eV of the ${\mathrm{Si}}_{2}$${\mathrm{H}}_{6}$ molecule containing a Si-Si bond. These results give experimental evidence for the Si-Si bond model of the 7.6-eV band in unirradiated ${\mathrm{SiO}}_{2}$ glass.
High-Contrast Infrared Absorption Spectroscopy via Mass-Produced Coaxial Zero-Mode Resonators with Sub-10 nm Gaps (2018)

We present a wafer-scale array of resonant coaxial nanoapertures as a practical platform for surface-enhanced infrared absorption spectroscopy (SEIRA). Coaxial nanoapertures with sub-10 nm gaps are fabricated via photolithography, atomic layer deposition of a sacrificial Al<sub>2</sub>O<sub>3</sub> layer to define the nanogaps, and planarization via glancing-angle ion milling. At the zeroth-order Fabry-Pérot resonance condition, our coaxial apertures act as a "zero-mode resonator (ZMR)", efficiently funneling as much as 34% of incident infrared (IR) light along 10 nm annular gaps. After removing Al<sub>2</sub>O<sub>3</sub> in the gaps and inserting silk protein, we can couple the intense optical fields of the annular nanogap into the vibrational modes of protein molecules. From 7 nm gap ZMR devices coated with a 5 nm thick silk protein film, we observe high-contrast IR absorbance signals drastically suppressing 58% of the transmitted light and infer a strong IR absorption enhancement factor of 10<sup>4</sup>∼10<sup>5</sup>. These single nanometer gap ZMR devices can be mass-produced via batch processing and offer promising routes for broad applications of SEIRA.
Topology Optimized Cloak for Airborne Sound (2013)

Directional acoustic cloaks that conceal an aluminum cylinder for airborne sound waves are presented in this paper. Subwavelength cylindrical aluminum inclusions in air constitute the cloak design to aid practical realizations. The positions and radii of the subwavelength cylinders are determined by minimizing scattering from the cloak-structure and cylinder using the gradient-based topology optimization method. In the final optimization step, the radii of the subwavelength cylinders are constrained to three discrete values. A near-perfect narrow-banded and angular cloaking effect is obtained by optimizing for one target frequency. To get a larger bandwidth, the acoustic cloak is optimized for three frequencies at the cost of reduced peak cloaking performance at the center frequency.
Nanoscale Deep Level Defect Correlation with Schottky Barriers in 4H-SiC/Metal Diodes (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Amyloid-Negative Dementia in the Elderly is Associated with High Accumulation of Tau in the Temporal Lobes (2019)

Background: We previously reported that among cases clinically diagnosed with Alzheimer’s disease, the proportion of amyloid beta (Aβ) -negative case increases in the elderly population. Tauopathy including Argyrophilic Grain Disease (AGD) and Neurofibrillary Tangle-Predominant Dementia (NFTPD), may be the leading causes of such dementia. Objective: To evaluate the involvement of tau, we studied tau accumulation in Amyloid-Negative Dementia Cases in the Elderly (ANDE) with Positron Emission Tomography (PET). Methods: Seven cases with slowly progressive dementia who were older than 80 years and were negative for Aβ were studied. In one case, autopsy obtained 2 years after the PET examination revealed neurofibrillary tangles limited around the parahippocampal gyrus. Four cases showed strong laterality in magnetic resonance imaging atrophy (clinical AGD), while the other three cases had no significant laterality in atrophy (clinical NFTPD). Age-corrected PET data of healthy controls (HC; n = 12) were used as control. Tau accumulation was evaluated with [ 11 C]PBB3-PET. Results: High accumulation was found in the lateral temporal cortex in ANDE. In autopsy case, scattered neurofibrillary tangles were found in the parahippocampal gyrus. In addition, there was a very high accumulation of PBB3 in the large area of bilateral parietal lobes, although no corresponding tau component was found in the autopsied case. Conclusion: Relatively high burden of tau deposition was commonly observed in the lateral temporal cortex and parietal cortex of ANDE, part of which may explain dementia in these subjects. [ 11 C]PBB3 may be useful in detecting tauopathy in ANDE.
Chapter 15. Liquid crystal glycolipids (2014)

There is a growing consciousness that the observed liquid crystallinity of many biological materials be related with their biological functions. While the survival of living systems depends on the flexibility and reformability of structures, the combination of softness and structure of the liquid crystalline state seems to determine the functionality of biological materials. The richest sources of liquid crystals derived from living systems are found in cell membranes, and glycolipids, which are important components of cell membranes, show fascinating self-assembling behaviour. In this chapter, by examining typical examples of liquid crystalline glycolipids with respect to their chemical structure, we will illustrate our understanding of the self-assembling and self-organising properties of glycolipids to the point of predictivity for rational design of mesomorphism in such systems.
2019 EACTS/EACTA/EBCP guidelines on cardiopulmonary bypass in adult cardiac surgery (2019)

Disclaimer 2019: The EACTS/EACTA/EBCP Guidelines represent the views of the EACTS, the EACTA and EBCP and were produced after careful consideration of the scientific and medical knowledge and the evidence available at the time of their dating. The EACTS, EACTA and EBCP are not responsible in the event of any contradiction, discrepancy and/or ambiguity between the EACTS, EACTA and EBCP Guidelines and any other official recommendations or guidelines issued by the relevant public health authorities, in particular in relation to good use of healthcare or therapeutic strategies. Health professionals are encouraged to take the EACTS, EACTA and EBCP Guidelines fully into account when exercising their clinical judgement as well as in the determination and the implementation of preventive, diagnostic or therapeutic medical strategies; however, the EACTS, EACTA and EBCP Guidelines do not, in any way whatsoever, override the individual responsibility of health professionals to make appropriate and accurate decisions in consideration of each patient’s health condition and, where appropriate and/or necessary, in consultation with that patient and the patient’s care provider. Nor do the EACTS, EACTA and EBCP Guidelines exempt health professionals from giving full and careful consideration to the relevant official, updated recommendations or guidelines issued by the competent public health authorities, in order to manage each patient’s case in light of the scientifically accepted data pursuant to their respective ethical and professional obligations. It is also the health professional’s responsibility to verify the applicable rules and regulations relating to drugs and medical devices at the time of prescription. The article has been co-published with permission in the British Journal of Anaesthesia, the European Journal of Cardio-Thoracic Surgery and the Interactive CardioVascular and Thoracic Surgery.
Packet Size Aware Path Setup For Wireless Networks (2008)

In this paper, we propose packet size aware path setup mechanisms for 802.11 based multi-hop WLAN networks. Path setup optimization is achieved by minimizing the transmission delay experienced by each packet traversing from source to the destination where different packets belonging to the same source destination pair can traverse different paths based on their sizes. We implemented a sample packet size aware path setup scheme as a Linux kernel module and experimentally showed the benefits of such a scheme in terms of the transmission delay and the throughput in an 802.11b WLAN environment. In addition to that we examine general path setup solutions for wireless networks considering packet size statistics.
Limitations in Mtbe Biodegradation (2003)

The methyl tert-butyl ether (MTBE) metabolic pathway was partially elucidated in Mycobacterium austroafricanum IFP 2012 by identifying the degradation intermediates. Several enzymatic activities were specifically induced during growth on MTBE. Among those required for the first steps of MTBE degradation to tert-butyl alcohol (TBA), the same monooxygenase was responsible for the oxidation of both MTBE and TBA, with a low affinity for TBA (Km = 1.1mM). An esterase was involved in the hydrolysis of tert-butyl formate (TBF). The slowness of the degradation of MTBE by M. austroafricanum IFP 2012 was the result of complex interactions, especially the negative effect of TBF formed during MTBE oxidation on the MTBE/TBA moonoxygenase and the absence of TBA oxidation in the presence of residual MTBE. Moreover, concerning the downstream steps of MTBE metabolism, Co++ ions were required for the degradation of 2-hydroxyisobutyric acid (HIBA) formed by oxidation of TBA as shown by the low growth yield on HIBA in the absence of cobalt.
Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs (2017)

Malaria remains a major threat to mankind due to the perpetual emergence of resistance against marketed drugs. Twenty-one pyrazolopyran-based inhibitors bearing terminal biphenyl, aryl sulfonamide, or aryl sulfone motifs were synthesized and tested towards serine hydroxymethyltransferase (SHMT), a key enzyme of the folate cycle. The best ligands inhibited Plasmodium falciparum (Pf) and Arabidopsis thaliana (At) SHMT in target, as well as PfNF54 strains in cell-based assays in the low nanomolar range (18-56 nm). Seven co-crystal structures with P. vivax (Pv) SHMT were solved at 2.2-2.6 Å resolution. We observed an unprecedented influence of the torsion angle of ortho-substituted biphenyl moieties on cell-based efficacy. The peculiar lipophilic character of the sulfonyl moiety was highlighted in the complexes with aryl sulfonamide analogues, which bind in their preferred staggered orientation. The results are discussed within the context of conformational preferences in the ligands.
Supplementary Figure 3 from Molecular Imaging of TGFβ-Induced Smad2/3 Phosphorylation Reveals a Role for Receptor Tyrosine Kinases in Modulating TGFβ Signaling (2023)

&lt;p&gt;PDF file - 17K&lt;/p&gt;