gebhart/patrepeval huggingface dataset:
Influence of propranolol and 4-hydroxypropranolol on platelet aggregation and thromboxane A2 generation (1983)

We examined in vitro effects of propranolol and its major metabolite, 4-hydroxypropranolol, on human platelets. Both propranolol and its 4-hydroxy metabolite had no significant direct effect on either platelet aggregation or TXA2 generation in therapeutic concentrations. Higher concentrations (greater than or equal to 10 micrograms/ml), however, reduced both parameters of platelet function. When propranolol and 4-hydroxypropranolol were incubated in combination with platelets in equal concentrations, there were synergistic effects on platelet aggregation and TXA2 generation. Neither propranolol nor 4-hydroxypropranolol inhibited platelet aggregation or TXA2 synthesis in sonicated platelets at any concentration, indicating that intact platelet membrane is necessary for their action.
Uptake and Intracellular Fate of Biocompatible Nanocarriers in Cycling and Noncycling Cells (2019)

All nanocarriers proved to be suitably biocompatible for both myoblasts and myotubes. The lower uptake capability of myotubes is probably due to different plasma membrane composition related to the differentiation process.
Three-Phase Rectifiers With Current Compensation Schemes - Part II: Active and Hybrid Configurations (2018)

The current injection schemes for unidirectional three-phase diode bridge rectifiers are widely utilised in industrial and aerospace applications. The additional circuitry in combination with modern control strategies mitigate the effects of the conversion in the mains, offers acceptable dynamic and reduces size/weight for the development of compact and robust power converters. This paper is the second part of this work and it overviews the most promoted self-commutated (active) and hybrids ac-dc configurations given in literature. The operation and characteristics of these proposals are reported in this review, extending the first part that focused the analysis on passive networks.
Tunable MEMS Spiral Inductors With Optimized RF Performance and Integrated Large-Displacement Electrothermal Actuators (2009)

We propose a tunable microelectromechanical systems integrated inductor with a large-displacement electrothermal actuator. Based on a transformer configuration, the inductance of a spiral inductor is tuned by controlling the relative position of a magnetically coupled short-circuited loop. The magnetic coupling between the inductors can be changed from 0.17 to 0.8 through an electrothermal actuator that can change their relative position by over 140 mum . For the first time, we investigate the impact of this tuning scheme on the inductance and quality factor and propose optimal designs. While a previous preliminary study has focused on keeping the ratio between the two coupled inductors close to one, we find that optimal performance is a weak function of this ratio. Instead, it primarily depends on the resistive loss of the short-circuited coil. Our theoretical studies are backed by a variety of fabricated and measured tunable inductors that show a ~2:1 inductance tuning ratio over a wide frequency range of approximately 25 GHz. In addition, the maximum and minimum quality factors of the tunable inductor are measured to be 26 and 10, respectively, which agree well with the theoretically expected values.
Probabilistic Neural Computing with Stochastic Devices (2022)

The brain has effectively proven a powerful inspiration for the development of computing architectures in which processing is tightly integrated with memory, communication is event-driven, and analog computation can be performed at scale. These neuromorphic systems increasingly show an ability to improve the efficiency and speed of scientific computing and artificial intelligence applications. Herein, it is proposed that the brain's ubiquitous stochasticity represents an additional source of inspiration for expanding the reach of neuromorphic computing to probabilistic applications. To date, many efforts exploring probabilistic computing have focused primarily on one scale of the microelectronics stack, such as implementing probabilistic algorithms on deterministic hardware or developing probabilistic devices and circuits with the expectation that they will be leveraged by eventual probabilistic architectures. A co-design vision is described by which large numbers of devices, such as magnetic tunnel junctions and tunnel diodes, can be operated in a stochastic regime and incorporated into a scalable neuromorphic architecture that can impact a number of probabilistic computing applications, such as Monte Carlo simulations and Bayesian neural networks. Finally, a framework is presented to categorize increasingly advanced hardware-based probabilistic computing technologies.
Transfer of the MDR1 (multidrug resistance) gene: protection of hematopoietic cells from cytotoxic chemotherapy, and selection of transduced cells in vivo. (1995)

Expression of the drug efflux pump P-glycoprotein, encoded by the multidrug resistance (MDR1) gene, has been identified as an impediment to successful chemotherapy of neoplastic diseases. More recently, its potential use for gene therapy has been analyzed. Expression of a full-length MDR1 cDNA in hematopoietic cells renders them resistant to various anticancer drugs, as first shown in a transgenic mouse model. Similarly, mouse hematopoietic progenitor cells in bone marrow or peripheral blood are protected from the toxicity of anticancer chemotherapy by retroviral transduction of the MDR1 gene. Furthermore, cells engineered to express P-glycoprotein survived after the administration of cytotoxic drugs, indicating that the gene could function as a selectable marker in vivo. Recently, MDR1 transduction into isolated pluripotent hematopoietic stem cells has been demonstrated. Clinical studies on MDR1 gene transfer into hematopoietic cells of cancer patients are being planned. Transfer of the MDR1 gene into hematopoietic precursor cells may allow the introduction and selection of otherwise non-selectable genes in bone marrow. The ability to select transduced cells can circumvent the low transduction efficiency that has hampered efficient gene therapy. Recently, fusion genes in which the MDR1 cDNA is fused to genes that correct genetic disorders have been constructed to facilitate gene therapy of inherited metabolic disorders.
Case Studies in Assisted Reproduction (2015)

Clinical case studies have long been recognized as a useful adjunct to problem-based learning and continuing professional development. They emphasize the need for clinical reasoning, integrative thinking, problem-solving, communication, teamwork and self-directed learning - all desirable generic skills for health care professionals. This volume contains a selection of cases on assisted reproduction that will inform and challenge reproductive medicine practitioners at all stages in their careers. Both common and uncommon cases are included. The aim is to reinforce diagnostic skill through careful analysis of individual presenting patterns, and to guide treatment decisions. Each case consists of a clinical history, examination findings and special investigations, before a diagnosis is made. Clinical issues raised by each case are discussed and major teaching points emphasized. Selective references are provided. The book provides a useful complementary adjunct to existing textbooks of reproductive medicine, and an excellent resource for teaching and continuing professional development.
Luminidependens (LD) is an Arabidopsis protein with prion behavior (2016)

Prion proteins provide a unique mode of biochemical memory through self-perpetuating changes in protein conformation and function. They have been studied in fungi and mammals, but not yet identified in plants. Using a computational model, we identified candidate prion domains (PrDs) in nearly 500 plant proteins. Plant flowering is of particular interest with respect to biological memory, because its regulation involves remembering and integrating previously experienced environmental conditions. We investigated the prion-forming capacity of three prion candidates involved in flowering using a yeast model, where prion attributes are well defined and readily tested. In yeast, prions heritably change protein functions by templating monomers into higher-order assemblies. For most yeast prions, the capacity to convert into a prion resides in a distinct prion domain. Thus, new prion-forming domains can be identified by functional complementation of a known prion domain. The prion-like domains (PrDs) of all three of the tested proteins formed higher-order oligomers. Uniquely, the Luminidependens PrD (LDPrD) fully replaced the prion-domain functions of a well-characterized yeast prion, Sup35. Our results suggest that prion-like conformational switches are evolutionarily conserved and might function in a wide variety of normal biological processes.
Spherical Swelling of Germ Tubes and Hyphae of Fusarium oxysporum by the Treatment with 5-fluoroindole. (1996)

[in Japanese]
New topology of direct current claw-pole machines for stop-start application (2018)

Purpose This paper aims to propose a new topology of direct current (DC) machine using claw-pole stator to replace standard DC starter in micro-hybrid vehicles. The main interest of such a topology is the reduction of copper volume. Design/methodology/approach The design of the claw-pole machine is based on a multi-objective optimization of several topologies, based on a three-dimensional (3D) reluctance network modeling. The 3D finite element (FE) model is used to check the results of the optimization, and a prototype is manufactured and tested with satisfactory results. Findings The claw-pole topology with wave-shape windings allows to replace the current DC series classical starter because of to its copper volume saving. Research limitations/implications This model is only limited to the optimization of the claw-pole stator for a fixed geometry of the rotor. Practical implications The research outcome shows that claw-pole machine can replace the series-excited DC machines of starters and at the same time achieve the same performance at reduced copper volume. Originality/value The paper deals with a new DC machine topology to reduce the copper volume through the suppression of the classical stator end-windings. The use of Claw-Pole inductors ensures this copper reduction.
Average downlink SINR model for 5G mmWave networks with analog beamforming (2018)

Millimeter-wave frequency bands enable the deployment of small-sized antenna arrays in the fifth generation of mobile networks, which provide high beamforming gain for both transmitter and receiver. In order to study user mobility, a computationally efficient simulator is needed that runs with a time step resolution that is higher than transmission-time-interval of cellular networks. In such simulators, typically the average downlink signal-to-interference-and-noise ratio (SINR) is used for radio link failure detection and throughput calculation. In this paper, models of desired and interfering signals are formulated first, by considering the impact of antenna beamforming at transmitter and receiver. Then, a closed-form expression of average downlink SINR is derived by taking into account the scheduling probabilities of the users. In addition, the closed form expression is approximated by Monte Carlo method. Simulations are performed to analyze the complexity and accuracy of Monte Carlo method along with the impact of user location and beamforming gain on average downlink SINR. Results confirm that the average downlink SINR is approximated accurately, and the computational complexity of the proposed method is tolerable. In addition, the results reveal that user location and beamforming have significant impact on the average downlink SINR.
6-Gingerdiols as the Major Metabolites of 6-Gingerol in Cancer Cells and in Mice and Their Cytotoxic Effects on Human Cancer Cells (2012)

6-Gingerol, a major pungent component of ginger (Zingiber officinale Roscoe, Zingiberaceae), has been reported to have antitumor activities. However, the metabolic fate of 6-gingerol and the contribution of its metabolites to the observed activities are still unclear. In the present study, we investigated the biotransformation of 6-gingerol in different cancer cells and in mice, purified and identified the major metabolites from human lung cancer cells, and determined the effects of the major metabolites on the proliferation of human cancer cells. Our results show that 6-gingerol is extensively metabolized in H-1299 human lung cancer cells, CL-13 mouse lung cancer cells, HCT-116 and HT-29 human colon cancer cells, and in mice. The two major metabolites in H-1299 cells were purified and identified as (3R,5S)-6-gingerdiol (M1) and (3S,5S)-6-gingerdiol (M2) based on the analysis of their 1D and 2D NMR data. Both metabolites induced cytotoxicity in cancer cells after 24 h, with M1 having a comparable effect to 6-gingerol in H-1299 cells.
Phosphinine stabilised gold nanoparticles; synthesis and immobilisation on mesoporous materials (2004)

The first synthesis of gold nanoparticles stabilised by a sub-stoichiometric amount of sp(2) phosphorus containing ligands was performed, as well as their immobilisation on mesostructured silica and titania hosts.
[Peritoneal splenosis manifested by infectious mononucleosis in an adolescent. Contribution of scintigraphy]. (1983)

This article does not deal with the general problem of splenosis, but with the pathology of splenic nodules implanted in the peritoneum. This condition is uncommon, and chiefly hematological and infectious in the index case. Although this issue is debated, functional activity of these nodules is substantiated, leading to consider therapeutical applications in some exceptional cases.
A Device for Zero-Eye-Movement Reading (1985)

A portable personal computer has been programmed as a flexible and economical text display device capable of delivering single and multiple words or symbols flashed in the center of the screen with a wide range of repetition times and duty cycles (fraction of stimulus on/off time). All aspects of a computer-controlled experiment are controlled by a command file which can be created by workers with basic word processing skills and no knowledge of computer programming. Digital output is provided for recording stimulus timing on a chart recorder or computer for comparison to eye movements or other externally recorded variables. The system is ideal for zero-eye-movement reading experiments in which sentences are flashed a word or group of words at a time in the center of a CRT screen. If the subject is then asked to repeat the sentence aloud, the percentage of words correctly recalled is a measure of "reading comprehension." Results with nine subjects match previous data [1] obtained cinematographically.
Supplementary Figure 5 from Targeting TRAIL Death Receptor 4 with Trivalent DR4 Atrimer Complexes (2023)

&lt;p&gt;PDF file, 55K, Surface DR4 knockdown. Surface DR4 by flow cytometry in HCT116 cells transfected with a scramble control or DR4 siRNA.&lt;/p&gt;
Fully Interconnected Globular Porous Biphasic Calcium Phosphate Ceramic Scaffold Facilitates Osteogenic Repair (2007)

An appropriate scaffold, which provides structural support for transplanted cells and acts as a vehicle for the delivery of biologically active molecules, is critical for tissue engineering. We developed a fully interconnected globular porous biphasic calcium phosphate ceramic scaffold by adopting a foaming method, and evaluated its efficiency as a bone substitute and a scaffold for bone tissue engineering by in vitro and in vivo biocompatible analysis and its osteogenic healing capacity in rat tibial bone defects. They have spherical pores averaging 400um in diameter and interconnecting interpores averaging 70um in diameter with average 85% porosity. They elicited no cytotoxicity and noxious effect on cellular proliferation and osteoblastic differentiation during the cell-scaffold construct formation. Also the bone defects grafted with fully interconnected globular porous biphasic calcium phosphate ceramic blocks revealed excellent bone healing within 3 weeks. These findings suggest that the fully interconnected porous biphasic calcium phosphate scaffold formed by the foaming method can be a promising bone substitute and a scaffold for bone tissue engineering.
Identification of Akt Association and Oligomerization Domains of the Akt Kinase Coactivator TCL1 (2002)

Serine/threonine kinase Akt/protein kinase B, the cellular homologue of the transforming viral oncogene v-Akt, plays a central role in the regulation of cell survival and proliferation. We have previously demonstrated that the proto-oncogene TCL1 is an Akt kinase coactivator. TCL1 binds to Akt and mediates the formation of oligomeric TCL1-Akt high-molecular-weight protein complexes in vivo. Within these protein complexes, Akt is preferentially phosphorylated and activated. The MTCP1/TCL1/TCL1b oncogene activation is the hallmark of human T-cell prolymphocytic leukemia (T-PLL), a form of adult leukemia. In the present study, using a PCR-generated random TCL1 library combined with a yeast two-hybrid screening detecting loss of interaction, we identified D16 and I74 as amino acid residues mediating the association of TCL1 with Akt. Based on molecular modeling, we determined that the beta C-sheet of TCL1 is essential for TCL1 homodimerization. Studies with mammalian overexpression systems demonstrated that both Akt association and oligomerization domains of TCL1 are distinct functional domains. In vitro kinase assays and overexpression experiments in mammalian cells demonstrated that both TCL1-Akt interaction and oligomerization of TCL1 were required for TCL1-induced Akt activation and substrate phosphorylation. Assays for mitochondrial permeability transition, nuclear translocation, and cell recovery demonstrated that both Akt association and homodimerization of TCL1 are similarly needed for the full function of TCL1 as an Akt kinase coactivator in vivo. The results demonstrate the structural basis of TCL1-induced activation of Akt, which causes human T-PLL.
Weakly supervised 3D Reconstruction with Adversarial Constraint (2017)

Supervised 3D reconstruction has witnessed a significant progress through the use of deep neural networks. However, this increase in performance requires large scale annotations of 2D/3D data. In this paper, we explore inexpensive 2D supervision as an alternative for expensive 3D CAD annotation. Specifically, we use foreground masks as weak supervision through a raytrace pooling layer that enables perspective projection and backpropagation. Additionally, since the 3D reconstruction from masks is an ill posed problem, we propose to constrain the 3D reconstruction to the manifold of unlabeled realistic 3D shapes that match mask observations. We demonstrate that learning a log-barrier solution to this constrained optimization problem resembles the GAN objective, enabling the use of existing tools for training GANs. We evaluate and analyze the manifold constrained reconstruction on various datasets for single and multi-view reconstruction of both synthetic and real images.
Monofunctional Near-Infrared Fluorochromes for Imaging Applications (2005)

In this report, the development of a new class of monocarboxylate functionalized cyanine derivatives using improved synthetic procedures is detailed. The employed synthetic strategy relies on efficient nucleophilic attack of alkyl-thiols on cyanine dyes bearing chloro-substituted polymethinic linkers. Monocarboxylate derivatized fluorochromes (CyTE dyes) can be prepared in one step in greater than 90% yield without the need for additional purification. Several of the fluorochromes synthesized by this route show no tendency to aggregate in aqueous solution and have excitation and emission maxima greater than 800 nm. The potential utility of the CyTE fluorochromes was demonstrated through direct labeling of phage displaying a vascular cellular adhesion molecule-1 (VCAM-1) targeting peptide. Endothelial cell internalization of the VCAM-1 targeted phage was monitored via near-infrared fluorescence microscopy.
A bandwidth-aware memory-subsystem resource management using non-invasive resource profilers for large CMP systems (2010)

By integrating multiple cores in a single chip, Chip Multiprocessors (CMP) provide an attractive approach to improve both system throughput and efficiency. This integration allows the sharing of on-chip resources which may lead to destructive interference between the executing workloads. Memorysubsystem is an important shared resource that contributes significantly to the overall throughput and power consumption. In order to prevent destructive interference, the cache capacity and memory bandwidth requirements of the last level cache have to be controlled. While previously proposed schemes focus on resource sharing within a chip, we explore additional possibilities both inside and outside a single chip. We propose a dynamic memory-subsystem resource management scheme that considers both cache capacity and memory bandwidth contention in large multi-chip CMP systems. Our approach uses low overhead, non-invasive resource profilers that are based on Mattson's stack distance algorithm to project each core's resource requirements and guide our cache partitioning algorithms. Our bandwidth-aware algorithm seeks for throughput optimizations among multiple chips by migrating workloads from the most resource-overcommitted chips to the ones with more available resources. Use of bandwidth as a criterion results in an overall 18% reduction in memory bandwidth along with a 7.9% reduction in miss rate, compared to existing resource management schemes. Using a cycle-accurate full system simulator, our approach achieved an average improvement of 8.5% on throughput.
An Environment for Named Entity Recognition and Translation (2009)

We present an environment for the recog-nition and translation of Named Entities (NEs). The environment consists of a new formalism for the Named Entity Recognition and Translation (NERT), a parsing mechanism that reads the rules, recognizes Named Entities in given texts and suggests their translation, as well as a set of tools for the evaluation. We sug-gest a method for the evaluation of (sets of) NERT rules that uses raw (not anno-tated) bilingual corpora. 1
Nanoflow liquid chromatography coupled to matrix‐assisted laser desorption/ionization mass spectrometry: Sample preparation, data analysis, and application to the analysis of complex peptide mixtures (2005)

We report the development of a robust interface for off-line coupling of nano liquid chromatography (LC) to matrix-assisted laser desorption/ionisation-mass spectrometry (MALDI-MS) and its application to the analysis of proteolytic digests of proteins, both isolated and in mixtures. The interface makes use of prestructured MALDI sample supports to concentrate the effluent to a small sample plate area and localize the MALDI sample to a predefined array, thereby enriching the analyte molecules and facilitating automated MALDI-MS analysis. Parameters that influence the preparation of MALDI samples from the LC effluent were evaluated with regard to detection sensitivity, spectra quality, and reproducibility of the method. A procedure for data processing is described. The presented nano LC MALDI-MS system allowed the detection of several peptides from a tryptic digest of bovine serum albumin, at analyzed amounts corresponding to one femtomole of the digested protein. For the identification of native proteins isolated from mouse brain by two-dimensional gel electrophoresis, nano LC MALDI-MS increased the number of detected peptides, thereby allowing identification of proteins that could not be identified by direct MALDI-MS analysis. The ability to identify proteins in complex mixtures was evaluated for the analysis of Escherichia coli 50S ribosomal subunit. Out of the 33 expected proteins, 30 were identified by MALDI tandem time of flight fragment ion fingerprinting.