gebhart/patrepeval huggingface dataset:
Unsupervised Motion Saliency Map Estimation Based On Optical Flow Inpainting (2019)

The paper addresses the problem of motion saliency in videos, that is, identifying regions that undergo motion departing from its context. We propose a new unsupervised paradigm to compute motion saliency maps. The key ingredient is the flow inpainting stage. Candidate regions are determined from the optical flow boundaries. The residual flow in these regions is given by the difference between the optical flow and the flow inpainted from the surrounding areas. It provides the cue for motion saliency. The method is flexible and general by relying on motion information only. Experimental results on the DAVIS 2016 benchmark demonstrate that the method compares favourably with state-of-the-art video saliency methods.
Case of Imatinib Susceptibility to CYP3A4-Mediated Drug–Drug Interactions in a Patient With Gastrointestinal Stromal Tumor (2022)

Fujimiya, Tatsuhiro PhD; Sugita, Hideki PhD; Kin, Masaoki MS; Funakoshi, Haruki BSc; Kubota, Yutaro MD, PhD; Tsunoda, Takuya MD, PhD Author Information
Television Viewing Time and Mortality (2010)

Television viewing time was associated with increased risk of all-cause and CVD mortality. In addition to the promotion of exercise, chronic disease prevention strategies could focus on reducing sitting time, particularly prolonged television viewing.
Phase I study of oncolytic virus (OV) MG1 maraba/MAGE-A3 (MG1MA3), with and without transgenic MAGE-A3 adenovirus vaccine (AdMA3) in incurable advanced/metastatic MAGE-A3-expressing solid tumours: CCTG IND.214. (2017)

e14637 Background: OVs display oncolytic activity and boost adaptive cell immunity. MG1MA3 is a Maraba virus modified to express tumour antigen MAGE-A3. MG1MA3, both alone and after immune priming with a MAGE-A3 modified adenovirus (AdMA3) may trigger anti-tumour T-cell responses. Methods: N = 41 patients (pts) with MAGE-A3 expressing solid tumours were evaluated in 3 groups (A) Dose escalation of MG1MA3 iv d1+4, q8w (n = 9); (B) Single fixed dose AdMA3 1e10 pfu IM d1 (n = 6); (C) AdMA3 priming d(-14) followed by dose escalated MG1MA3 (d1+4, q8w) (n = 25). Arm A and C had a 3+3 design. Pre + post treatment blood and tissue biopsies were evaluated for viral and immune markers. Endpoints included MTD/MFD, RP2DL, safety, tolerability, pharmacokinetics, viral delivery and replication. Results: Dose limiting toxicities (hypoxia/dyspnea, vomiting, headache) occurred in 4 pts (2 each Arm A +C). RP2DL for arm C was AdMA3 1e10 pfu IM d(-14) then MG1MA3 1e11 pfu iv d1+4. Common treatment related toxicities on Arm C occurring hours to a few days after MG1MA3 included diarrhea, nausea, vomiting, anorexia, chills, fatigue, fever, flu-like symptoms, hypophosphatemia, headache, and hypotension. Preliminary tumour gene expression results reveal induction of pro-inflammatory genes, including chemokines (CCL2, CCL5, CX3CL1, CXCL10), acute phase response proteins (IL-6, TNF), antigen presenting cell (APC) activation markers (CD80, HLA-A, HLA-B), markers of APC and Natural Killer cell infiltration (CD56, CD68, TLR3), as well as a co-incident decrease in the suppressive cytokine TGF-β. MG1MA3 replication was observed in some pts, inferred by detection of circulating genomes on days 4, 8 and 15 after clearance of the input dose. Induction of anti-tumour immune responses (CD8 T cells and antibodies vs MAGE-A3) was demonstrated in 3 of 6 Arm C pts evaluated to date. In one patient, over 1% of circulating CD8 T cells were directed against MAGE-A3. Conclusions: AdMA3 prime followed by MG1MA3 OV boost is feasible with a defined RP2DL, and capable of inducing potent anti-tumour immune response. Alternate schedules will be evaluated. Clinical trial information: NCT02285816.
Alexander Stepanovich Ardemasov: Party director of the Leningrad Pharmaceutical Institute in 1940-1942 (2020)

Based on unpublished archival documents from the Central State Archive of Party Historical Documents, the article reconstructs the biography of A.S. Ardemasov, a party worker, the Director of the Leningrad Pharmaceutical Institute (now Saint Petersburg State Chemical and Pharmaceutical University) in the pre-war period, during the Great Patriotic War (WWII) and the post-war years. During his path of life, A.S. Ardemasov headed the leading chemical enterprises of the USSR: the Leningrad Laminated Plastics Plant (now the Laminated Plastics Plant, LLC, St. Petersburg), the State Institute of Applied Chemistry (now the Russian Scientific Center of Applied Chemistry).
Effect of Molecular Weight on Network Formation in Linear ABC Triblock Copolymers (2006)

A series of linear poly(isoprene-b-styrene-b-ethylene oxide) (ISO) triblock copolymers were synthesized to investigate the effects of molecular weight and segregation strength on block copolymer network phases. Analysis of small-angle X-ray scattering (SAXS), dynamic mechanical spectroscopy (DMS), and transmission electron microscopy (TEM) data shows that several factors influence network formation. Increasing the polymer molecular weight 50−100% above the value necessary to place the order−disorder transition temperature within an experimentally accessible range leads to disruption of long-range order at compositions associated with the orthorhombic O70 phase in freeze-dried and annealed specimens. Comparable molecular weight three-domain lamellae (LAM3) behave differently, exhibiting well-ordered morphologies that closely resemble the correlated layers found in diblock copolymers. These findings are interpreted on the basis of the reduction in molecular diffusion that accompanies increasing molecular weight and segregation strength, bridging across the poly(styrene) middle block, and differences in domain topology. These kinetic restrictions can inhibit establishment of equilibrium phase behavior in ABC triblock copolymers but do not necessarily eliminate formation of multifunctional triply periodic materials.
Analysis and design of a zero voltage switching DC-to-AC inverter (2002)

In this paper, the authors present a simplified steady state analysis and design for a DC-to-AC inverter with zero-voltage-switching (ZVS) and output isolation. It is a current-fed power converter having variable frequency control to obtain a symmetrical regulated AC output. Two switches operating in complementary fashion to control the operation of the converter and provide transformer core resetting. The resonance between the parasitic capacitances, transformer magnetizing inductance, and output side inductor allow ZVS for both switches, hence, reducing switching losses. The output has an LCC resonant tank circuit which controls the output power flow, and sets the frequency of the output AC voltage. Using simplified steady-state analysis, input and output characteristic curves are derived for different transformer ratios. Based on these curves, a design procedure with a specific example supported by simulation results is presented.
Synthetic vision for general aviation: opportunities and requirements (2002)

The opportunities provided by a synthetic vision system depend on the ability of the sensors and databases to meet the requirements imposed by the intended functions. Based on the data requirements, this paper addresses the question whether in general aviation an incremental approach is possible by means of retrofitting certain synthetic vision system components that have the potential to increase safety and ease of use.
1096 mWTX-330, an IL-12 INDUKINE molecule, selectively activates tumor infiltrating lymphocytes and reprograms the tumor microenvironment in murine syngeneic tumor models (2022)

<h3>Background</h3> Cytokines are powerful modulators of the immune system, making them a promising target for novel cancer immunotherapies. IL-12 is a pleotropic cytokine that acts on various immune cell populations, including professional APCs as well as adaptive and innate effector cells. Furthermore, recombinant IL-12 generates robust anti-tumor activity in murine models. However, its clinical use has been impeded by a poor pharmacokinetic profile and severe, sometimes fatal, adverse events following systemic administration. mWTX-330 is a selectively inducible IL-12 containing pro-drug (INDUKINE™ molecule) that is comprised of chimeric IL-12 (human p40, mouse p35) linked to a half-life extension domain and an inactivation domain by protease cleavable linkers. Following systemic administration, the inactivation domain keeps the molecule inactive in the periphery, while selective processing of the linkers in the tumor microenvironment results in the local release of chimeric IL-12. <h3>Methods</h3> Mice bearing syngeneic tumors were treated with mWTX-330, and tumor growth and body weight were monitored over time. In some experiments tissues were harvested at various timepoints, and analyzed by flow cytometry, NanoString analysis, or other downstream techniques. <h3>Results</h3> mWTX-330 generated robust anti-tumor immunity in multiple syngeneic tumor models, including MC38, CT26, B16-F10, and EMT-6. Antibody based depletion of the CD8+ T cells resulted in a loss of late tumor control, while depletion of CD8+ T cells, CD4+ T cells, and NK cells resulted in a complete loss of tumor control following mWTX-330 treatment. Furthermore, mWTX-330 treated mice that rejected primary tumors were protected against later rechallenge with the same tumor cell line. Systemic mWTX-330 treatment selectively activated tumor infiltrating immune cells, with little evidence of immune cell activation in the peripheral blood or secondary lymphoid tissues. Likewise, mWTX-330 was better tolerated than chimeric IL-12, while maintaining efficacy at a similar dose, resulting in a significant expansion of the therapeutic window due to the INDUKINE design of this molecule. Additionally, mWTX-330 treatment increased the frequency of polyfunctional CD8+ T cells, skewed CD4+ non-Tregs towards a TH1 phenotype, robustly drove NK cell production of effector cytokines within the tumor and triggered a metabolic re-invigoration of effector cells. <h3>Conclusions</h3> These data highlight the preclinical potency and selective inducibility of mWTX-330 in various murine syngeneic tumor models. More importantly, they demonstrate the feasibility of the INDUKINE approach to address the clinical roadblocks seen with IL-12 therapy and support the ongoing clinical development of our IL-12 INDUKINE molecule containing a fully human payload, WTX-330.
Adversarial Latent Autoencoders (2020)

Autoencoder networks are unsupervised approaches aiming at combining generative and representational properties by learning simultaneously an encoder-generator map. Although studied extensively, the issues of whether they have the same generative power of GANs, or learn disentangled representations, have not been fully addressed. We introduce an autoencoder that tackles these issues jointly, which we call Adversarial Latent Autoencoder (ALAE). It is a general architecture that can leverage recent improvements on GAN training procedures. We designed two autoencoders: one based on a MLP encoder, and another based on a StyleGAN generator, which we call StyleALAE. We verify the disentanglement properties of both architectures. We show that StyleALAE can not only generate 1024x1024 face images with comparable quality of StyleGAN, but at the same resolution can also produce face reconstructions and manipulations based on real images. This makes ALAE the first autoencoder able to compare with, and go beyond the capabilities of a generator-only type of architecture.
Vaccins à ADN et à ARN: des technologies également utilisées en vaccinologie vétérinaire (2021)

Dory Daniel,Jestin André. Vaccins à ADN et à ARN : des technologies également utilisées en vaccinologie vétérinaire. In: Bulletin de l'Académie Vétérinaire de France tome 174, 2021. pp. 113-116.
Theoretical and experimental results of tubular linear induction generator for Stirling cogenerator system (2010)

The purpose of this paper is to address tubular linear induction machine which is the electric generator of the Stirling cogenerator system. The architecture is original. To our best knowledge, there has not been any linear asynchronous generator being commercialized. The electrical generation comes from the conversion of mechanical energy due to the beatings of a piston surrounding the coils, in which the induced currents are generated. Because of these beats, the piston's speed changes continuously that the system is in transient regime. The modeling of this generator is complex, particularly because of the end effects. In this article, after a brief presentation of the analytical model, the results of this model will be compared with the measurements. This project is financed by ANR.
237 IN-VIVO QUANTITATIVE T2 MAPPING OF CAROTID PLAQUES IN PATIENTS WITH RECENT CEREBROVASCULAR EVENTS: AHA PLAQUE TYPE CLASSIFICATION AND CORRELATION WITH PLAQUE HISTOLOGY (2013)

Introduction Although in-vivo multicontrast MRI is capable of characterizing atherosclerotic plaques in carotid arteries, its non-quantitative nature and the need for extensive post-acquisition interpretation limit its widespread clinical application. Quantitative T2 mapping is a promising alternative since it can provide an absolute physical measure of plaque components that can be standardised among different MRI systems and widely adopted in multi-centre studies. The purpose of this pilot study is to seek the potential of in-vivo T2 mapping and its correlation with different plaque components ex-vivo on histology. Methods 3T-MRI : 15 asymptomatic patients (11 males, 71±10 years) and 13 patients scheduled for endarterectomy (9 males, 70±17 years) were imaged at 3T using the conventional multicontrast protocol and Multiple-Spin-Echo (Multi-SE). T2 maps were generated by mono-exponential fitting to the series of images acquired by Multi-SE using non-linear least-squares regression. Two reviewers independently classified plaque types according to the MRI-modified AHA scheme, one using T2 maps+TOF images, the other using multicontrast MRI. Histology Carotid plaques were freshly obtained at time of endarterectomy. Plaques were divided at the level of maximal stenosis and 4mm-segments on either side of the cut were processed for formalin-fixed, paraffin-embedded (FFPE) sections and cryosections, respectively. FFPE sections were stained for H&amp;E and Masson’s trichrome, while cryosections were used for Oil-Red-O/adipophilin (foam cells marker) staining to visualize lipid. MRI-histology matching was performed for each segment using the carotid bifurcation as the common anatomical landmark. AHA plaque type was determined by an independent reviewer. Results In the 15 asymptomatic patients, AHA plaque type classified on multicontrast MRI and on T2 maps (+TOF) showed good agreement (76% of matching classifications and Cohen’s κ=0.68). 4 of the 13 patients scheduled for endarterectomy were excluded due to severe MRI motion artefacts. AHA type classification of the remaining 9 plaques using T2 maps (+TOF) vs. histology is presented in Table 1. Figure 1 shows a type VI and Figure 2 a type IV-V plaque. T2 maps were able to differentiate lipid-rich necrotic core (LRNC), fibrous tissue, calcification, and recent intraplaque-haemorrhage (IPH). Conslusions These preliminary results show the potential of in-vivo T2 mapping for atherosclerotic plaque characterization. Agreement between AHA plaque types classified by T2 maps (+TOF) and by conventional multicontrast MRI was good. The ability of T2 maps to discriminate LRNC, fibrous tissue and recent IPH was confirmed by histology. Further prospective quantitative validation study is now underway.
Quasi-TEM Fabry-Perot cavities with high aperture efficiency (2007)

International audience
Changing the Energy Habitat of the Cancer Cell in Order To Impact Therapeutic Resistance (2011)

Somatic cellular evolution is becoming a popular biological explanation for the common rapid development of resistance to almost every form of cancer therapy and against almost every form of advanced human solid tumors. As a result of the historical power of evolution within nature, this common biological interpretation of the failure of cancer therapy is leading to a growing despair for many investigators and a stronger turn toward prevention through lifestyle changes. The absolute explosion of molecular scientific discoveries since 1983, in the reductionist identification of specific cancer therapeutic targets, has failed to deliver the impact in the clinic that many of us would have hoped would have resulted by this time. Personalized molecular medicine may help us reclassify appropriate therapeutic subgroups, but will it significantly impact the overall specific survival times for all of the cancers combined within the organ type for the entire population? How might we approach this therapeutic dilemma by utilizing new therapeutic insights designed on proven principles of evolution? In other words, can we fight the development of therapeutic resistance in cancer cells by turning established aspects of evolution against the survival of cancer cells within the individual patient? Here we review the concepts of changing the heat habitat and microenvironment of the cancer cell to alter the higher order organization and function of DNA. We have proposed that heat may be a major factor in determining the lasting therapeutic effect on many types of far advanced metastatic tumors.
Hairpin formation within the enhancer region of the human enkephalin gene. (1991)

The 3',5'-cyclic adenosine monophosphate (cAMP)-inducible enhancer of the human enkephalin gene is located within an imperfect palindrome of 23 base pairs. We have found that a 23-base-pair oligonucleotide duplex containing the enhancer undergoes a reversible conformational transition from the duplex to two individual hairpin structures each formed from one strand of the duplex. Each individual hairpin forms with mismatched base pairs, one containing two GT pairs and the other containing two AC pairs. The conformational transition is stabilized by proton transfer to the hairpin containing AC mismatched pairs. The unique physical and thermodynamic properties of the enkephalin enhancer DNA suggest a model in which DNA secondary structure within the enhancer region plays an active role in cAMP-inducible activation of the human enkephalin gene via formation of cruciform structures.
Dynamic Nonprehensile Manipulation: Controllability, Planning, and Experiments (1999)

We are interested in using low-degree-of-freedom robots to perform complex tasks by nonprehensile manipulation (manipulation without aformorforce-closure grasp). By notgrasping, the robot can usegravitational, centrifugal, and Coriolisforces as virtual motors to control more degrees of freedom of the part. The part s extra motionfreedoms are exhibited as rolling, slipping, and free flight. This paper describes controllability, motion planning, and implementation ofplanar dynamic nonprehensile manipukltion. We show that almost any planar object is controllable by point contact, and the controlling robot requires only twvo degrees of freedom (a point translating in the plane). We then focus on a one-joint manipulator (with a two-dimensional state space), and show that even this simplest of robots, by using slipping and rolling, can control a planar object to a fulldimensional subset of its six-dimensional statespace. We have developed a one-jointrobotto perform a variety of dynamic tasks, including snatching an object ftom a table, rolling an object on the surface of the arm, and throwing and catching. Nonlinear optimization is used to plan robot trajectories that achieve the desired object motion via coupling forces though the nonprehensile contact.
Distill and Collect for Semi-Supervised Temporal Action Segmentation (2022)

Recent temporal action segmentation approaches need frame annotations during training to be effective. These annotations are very expensive and time-consuming to obtain. This limits their performances when only limited annotated data is available. In contrast, we can easily collect a large corpus of in-domain unannotated videos by scavenging through the internet. Thus, this paper proposes an approach for the temporal action segmentation task that can simultaneously leverage knowledge from annotated and unannotated video sequences. Our approach uses multi-stream distillation that repeatedly refines and finally combines their frame predictions. Our model also predicts the action order, which is later used as a temporal constraint while estimating frames labels to counter the lack of supervision for unannotated videos. In the end, our evaluation of the proposed approach on two different datasets demonstrates its capability to achieve comparable performance to the full supervision despite limited annotation.
Photoluminescence and optical absorption in neutron-irradiated crystalline quartz (1996)

Optical absorption measurements in the 3.5--6.5 eV spectral range and photoluminescence spectra, excited in the 4--8 eV range have been performed on neutron irradiated synthetic crystalline quartz as a function of temperature and of neutron fluence. The Gaussian deconvolution of the radiation-induced absorption spectrum in the 4.5--6 eV region reveals a complex structure: five distinct components, peaking at 4.85, 5.06, 5.35, 5.62, and 5.96 eV are detected. The complexity of the absorption pattern finds a correspondence in photoluminescence spectra excited in the 5 eV region: a detailed analysis of the emission spectra as a function of excitation energy indicates the presence of three emission bands centered at 3.91, 4.23, and 4.46 eV, excited at 5.25, 4.83, and 5.03 eV respectively. Excitation in the 5.62 and 5.96 eV absorption peaks does not produce emission. The features of the 4.23 eV and of the 4.46 eV bands are very similar to those of the ${\mathrm{\ensuremath{\alpha}}}_{\mathrm{intrinsic}}$ emission, already well studied in amorphous ${\mathrm{SiO}}_{2}$: this suggests a possible correlation between these bands and the ${\mathrm{\ensuremath{\alpha}}}_{\mathrm{}\mathrm{intrinsic}}$ center. The 3.91 eV band does not find a correspondence in amorphous ${\mathrm{SiO}}_{2}$, and so the responsible defect appears specifically related to the crystalline structure. The emission spectra excited in the E absorption band (\ensuremath{\approxeq}7.6 eV) present a weak band centered at 4.83 eV: its dependence on neutron irradiation dose suggests the attribution to an intrinsic center different from those responsible for the emission in the 3.8 -- 4.5 eV region. \textcopyright{} 1996 The American Physical Society.
Characteristics of SrTiO3Insulated Layer in SBT Ferroelectric Thin Films (2009)

Abstract Low temperature processing of SBT thin films with SrTiO 3 (STO) seeded layer deposited onto Ir/SiO 2 /Si (MIM structure) and CeO 2 /Si (MFIS structure) substrate using MOD method was investigated. The Sr 0.8 Bi 2.6 Ta 2 O 9 + x (SBT) thin films with a STO seeded layer on MIM structure showed prefer (115) orientation, well crystalline and lower crystal temperature than those without STO seeded layer. The SBT thin films with STO seeded layer on MFIS structure also showed prefer (115), (006) orientation and well crystalline SBT phase annealed at 700°C. The seeded layer, STO, effectively protected the evaporation of Bi through the Pt top electrode and diffusion of Bi into the Ir bottom electrode on MIM structure. It also can improve the crystallization of SBT phase, grain growth and lower crystallized temperature of SBT thin film. The memory window and leakage current densities of SBT thin films with STO seeded layers are improved significantly in comparison with those films without the STO seeded layer. In the MIM structure, the SBT thin film with STO seeded layer can decrease the leakage current density to 10−9 A/cm 2 at 100 kV/cm. In the MFIS structure, the SBT thin film with STO seeded layer also can improve the memory window and lead to lower leakage current at low voltage. Keywords: STOSBTferroelectric thin filmleakage current