gebhart/patrepeval huggingface dataset:
Mac-1 (CD11b/CD18) is essential for Fc receptor–mediated neutrophil cytotoxicity and immunologic synapse formation (2001)

Receptors for human immunoglobulin (Ig)G and IgA initiate potent cytolysis of antibody (Ab)-coated targets by polymorphonuclear leukocytes (PMNs). Mac-1 (complement receptor type 3, CD11b/CD18) has previously been implicated in receptor cooperation with Fc receptors (FcRs). The role of Mac-1 in FcR-mediated lysis of tumor cells was characterized by studying normal human PMNs, Mac-1-deficient mouse PMNs, and mouse PMNs transgenic for human FcR. All PMNs efficiently phagocytosed Ab-coated particles. However, antibody-dependent cellular cytotoxicity (ADCC) was abrogated in Mac-1(-/-) PMNs and in human PMNs blocked with anti-Mac-1 monoclonal Ab (mAb). Mac-1(-/-) PMNs were unable to spread on Ab-opsonized target cells and other Ab-coated surfaces. Confocal laser scanning and electron microscopy revealed a striking difference in immunologic synapse formation between Mac-1(-/-) and wild-type PMNs. Also, respiratory burst activity could be measured outside membrane-enclosed compartments by using Mac-1(-/-) PMNs bound to Ab-coated tumor cells, in contrast to wild-type PMNs. In summary, these data document an absolute requirement of Mac-1 for FcR-mediated PMN cytotoxicity toward tumor targets. Mac-1(-/-) PMNs exhibit defective spreading on Ab-coated targets, impaired formation of immunologic synapses, and absent tumor cytolysis.
From Copernicus Big Data to Extreme Earth Analytics (2019)

Copernicus is the European programme for monitoring the Earth. It consists of a set of systems that collect data from satellites and in-situ sensors, process this data and provide users with reliable and up-to-date information on a range of environmental and security issues. The data and information processed and disseminated puts Copernicus at the forefront of the big data paradigm, giving rise to all relevant challenges, the so-called 5 Vs: volume, velocity, variety, veracity and value. In this short paper, we discuss the challenges of extracting information and knowledge from huge archives of Copernicus data. We propose to achieve this by scale-out distributed deep learning techniques that run on very big clusters offering virtual machines and GPUs. We also discuss the challenges of achieving scalability in the management of the extreme volumes of information and knowledge extracted from Copernicus data. The envisioned scientific and technical work will be carried out in the context of the H2020 project ExtremeEarth which starts in January 2019
Mix to Validate: A Facile, Reversible PEGylation for Fast Screening of Potential Therapeutic Proteins In Vivo (2013)

Happy TRAILs to you: PEGylation of proteins through complementary interactions between a His-tag and a Ni2+ complex of nitrilotriacetic acid (NTA, see picture), a well-established practice in protein research, was used to improve the half-life of therapeutic proteins in the blood following systemic administration in vivo. Animal models show that this site-specific modification improves the efficacy of modified TRAIL proteins. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Moving target detection and tracking in wireless sensor networks (2007)

Wireless sensor networks (WSNs) are receiving an increasing interest because of their ease of deployment, autonomous re-configuration capabilities, and small cost. They can be employed in a large variety of applications, from military and surveillance to environmental monitoring. Since on board batteries only provide a limited energy resource to nodes and often they cannot be replaced, when designing WSN-based applications a fundamental issue is the reduction of power consuming operations. In this paper we exploit a WSN for detecting and tracking moving targets. Such a network would waste energy if all nodes were kept constantly active, since at every time instant the target is in the range of only a subset of them. For this reason an autonomous target detection algorithm and a cooperative selective-activation tracking algorithm are proposed, and the use of Kalman filtering techniques for motion estimation is discussed. In particular, the problem of fusing the data obtained from different sensors is considered. Simulations results in different scenarios are presented.
Binding of condensed tannins to salivary proline-rich glycoproteins: the role of carbohydrate (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBinding of condensed tannins to salivary proline-rich glycoproteins: the role of carbohydrateThomas N. Asquith, John Uhlig, Haile Mehansho, Lesley Putman, Don M. Carlson, and Larry ButlerCite this: J. Agric. Food Chem. 1987, 35, 3, 331–334Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://pubs.acs.org/doi/10.1021/jf00075a012https://doi.org/10.1021/jf00075a012research-articleACS PublicationsRequest reuse permissionsArticle Views329Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Negative Regulation of β Enolase Gene Transcription in Embryonic Muscle Is Dependent upon a Zinc Finger Factor That Binds to the G-rich Box within the Muscle-specific Enhancer (1998)

We have previously identified a muscle-specific enhancer within the first intron of the human beta enolase gene. Present in this enhancer are an A/T-rich box that binds MEF-2 protein(s) and a G-rich box (AGTGGGGGAGGGGGCTGCG) that interacts with ubiquitously expressed factors. Both elements are required for tissue-specific expression of the gene in skeletal muscle cells. Here, we report the identification and characterization of a Kruppel-like zinc finger protein, termed beta enolase repressor factor 1, that binds in a sequence-specific manner to the G-rich box and functions as a repressor of the beta enolase gene transcription in transient transfection assays. Using fusion polypeptides of beta enolase repressor factor 1 and the yeast GAL4 DNA-binding domain, we have identified an amino-terminal region responsible for the transcriptional repression activity, whereas a carboxyl-terminal region was shown to contain a potential transcriptional activation domain. The expression of this protein decreases in developing skeletal muscles, correlating with lack of binding activity in nuclear extract from adult skeletal tissue, in which novel binding activities have been detected. These results suggest that in addition to the identified factor, which functionally acts as a negative regulator and is enriched in embryonic muscle, the G-rich box binds other factors, presumably exerting a positive control on transcription. The interplay between factors that repress or activate transcription may constitute a developmentally regulated mechanism that modulates beta enolase gene expression in skeletal muscle.
Microscopic Reaction Site Model for Cathodic Reduction of Lead Sulfate to Lead (1992)

The cathodic reduction of lead sulfate to lead was investigated by using the potential sweep method. A microscopic reaction site model was proposed in order to discuss the current‐potential curves of the cathodic reduction of lead sulfate to lead. In this study it was assumed that the reaction occurred at the interface between the lead and the lead sulfate crystals. The electrochemical kinetics of the cathodic reduction of the lead sulfate at the reaction site was assumed to be controlled by the diffusion of lead ion. The current‐potential curve was explained by the change of the reaction site area and the diffusion of lead ion. The electrochemical behavior of a lead/lead sulfate electrode is in good agreement with the model proposed in this study. The effects of crystal size, solubility, diffusion coefficient, and length of diffusion path on the reduction of lead sulfate to lead were examined.
Supplementary Figure Legends 1-2 from α<sub>v</sub>β<sub>3</sub>/α<sub>v</sub>β<sub>5</sub> Integrins-FAK-RhoB: A Novel Pathway for Hypoxia Regulation in Glioblastoma (2023)

Supplementary Figure Legends 1-2 from α&lt;sub&gt;v&lt;/sub&gt;β&lt;sub&gt;3&lt;/sub&gt;/α&lt;sub&gt;v&lt;/sub&gt;β&lt;sub&gt;5&lt;/sub&gt; Integrins-FAK-RhoB: A Novel Pathway for Hypoxia Regulation in Glioblastoma
Direct measurement of tubulin and bulk message distributions on polysomes of growing, starved and deciliatedTetrahymenausing RNA gel blots of sucrose gradients containing acrylamide (1988)

A method was developed using sucrose gradients containing acrylamide which greatly simplifies the measurement of the polysomal distribution of messages. After centrifugation, the acrylamide was polymerized, forming a "polysome gel". RNA gel blots of polysome gels were used to determine the polysomal distributions of alpha-tubulin and total polyadenylated mRNA in growing, starved (nongrowing) and starved-deciliated Tetrahymena and the number of messages loaded onto polysomes was calculated. These measurements indicated that the translational efficiencies of alpha-tubulin mRNA and total polyadenylated mRNA are largely unaffected when the rates of tubulin and total protein synthesis vary dramatically. Thus, differential regulation of alpha-tubulin mRNA translation initiation does not contribute to the greater than 100-fold induction of tubulin synthesis observed during cilia regeneration and in growing cells. The major translation-level process regulating tubulin synthesis in Tetrahymena appears to be a change in message loading mediated by a non-specific message recruitment or unmasking factor.
On the size of the singlet-triplet energy gap in trimethylenemethanes (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the size of the singlet-triplet energy gap in trimethylenemethanesMatthew S. Platz and Jerome A. BersonCite this: J. Am. Chem. Soc. 1977, 99, 15, 5178–5180Publication Date (Print):June 1, 1977Publication History Published online1 May 2002Published inissue 1 June 1977https://doi.org/10.1021/ja00457a048RIGHTS & PERMISSIONSArticle Views64Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (428 KB) Get e-Alertsclose Get e-Alerts
A HIGH PERFORMANCE LIQUID-NITROGEN CMOS SRAM TECHNOLOGY (1988)

A 3.5 ns ECL-compatible 64Kb liquid-nitrogen CMOS (LN-CMOS) SRAM technology with 2.5V power-supply voltage is described. Key features of this high performance 0.5µm-channel LN-CMOS SRAM technology optimized for 77K operation include 0.6µm optical lithography for the gate level, dual polysilicon work functions, retrograde n-well, low resistance arsenic and boron source/drain diffusions, self-aligned titanium silicide, and two-level metal interconnects. For the first time, the leverage of liquid nitrogen CMOS with 2.3X chip level performance improvement at 77K over room temperature CMOS is demonstrated.
Spectroscopy and Kinetics of Singlet Perfluoro-4-biphenylnitrene and Singlet Perfluorophenylnitrene (1997)

Laser flash photolysis (LFP) of perfluorophenyl azide and perfluoro-4-biphenyl azide produces the corresponding singlet nitrenes which were detected by their transient absorptions at 330 and 350 nm, respectively. The absolute rate constants of the fundamental processes that consume the singlet nitrenes (intersystem crossing, kisc, rearrangement, kR; reaction with pyridine, kpyr) were determined by monitoring the decay of the singlet nitrene and by the growth of its reaction products (ketenimine, triplet nitrene, or pyridine ylide). In the case of singlet 4-perfluorobiphenylnitrene in CH2Cl2 kisc = (2.2 ± 0.1) × 106 s-1, kR = 1013.2±0.2 exp[−(9400 ± 400)/RT] s-1, and kpyr = 109.06±0.15 exp[−(2400 ± 200)/RT] M-1 s-1. In the case of singlet perfluorophenylnitrene in CH2Cl2 kisc = (1.05 ± 0.05) × 107 s-1, kR = 1013.8±0.3 exp[−(8800 ± 400)/RT] s-1, and kpyr = 109.00±0.13 exp[−(1600 ± 160)/RT] M-1 s-1.
Equivalence of the McAllister and Heric Equations for Correlating the Liquid Viscosity of Multicomponent Mixtures (2010)

This paper demonstrates the equivalence between two equations for correlating liquid kinematic viscosities: the Heric and McAllister equations. For ternary and multicomponent mixtures, the only difference is in the ternary interaction term. If this term is constant, both equations correlate the viscosity data identically. This approach can prove the equivalence of the Nissan and Grunberg equation and the Frenkel equation to correlate the dynamic viscosity of liquid mixtures. Examples are included for binary and ternary mixtures.
Analysis of Multipath Propagation in Urban Environment Through Multidimensional Measurements and Advanced Ray Tracing Simulation (2008)

A multidimensional analysis of multipath propagation in urban micro- and macro-cellular environment has been carried out. Multidimensional measurement data, including path-loss, delay spread and direction-of-arrival are compared with simulations performed with a 3D ray tracing model which takes diffuse scattering into account. The results are analyzed highlighting the dominant propagation mechanisms in the different cases and model performance/shortcomings. In particular, the results show that diffuse scattering plays a key role in urban propagation, with an impact on both narrowband and wideband parameters in most cases. Also, the accuracy and the characteristics of environment representation can have a significant impact on prediction even in simple topologies.
Analysis of end‐to‐end multi‐domain management and orchestration frameworks for software defined infrastructures: an architectural survey (2016)

Abstract Over the last couple of years, industry operators' associations issued requirements towards an end‐to‐end management and orchestration plane for 5G networks. Consequently, standard organisations started their activities in this domain. This article provides an analysis and an architectural survey of these initiatives and of the main requirements, proposes descriptions for the key concepts of domain, resource and service slicing, end‐to‐end orchestration and a reference architecture for the end‐to‐end orchestration plane. Then, a set of currently available or under development domain orchestration frameworks are mapped to this reference architecture. These frameworks, meant to provide coordination and automated management of cloud and networking resources, network functions and services, fulfil multi‐domain (i.e. multi‐technology and multi‐operator) orchestration requirements, thus enabling the realisation of an end‐to‐end orchestration plane. Finally, based on the analysis of existing single‐domain and multi‐domain orchestration components and requirements, this paper presents a functional architecture for the end‐to‐end management and orchestration plane, paving the way to its full realisation. Copyright © 2016 The Authors. Transactions on Emerging Telecommunications Technologies Published by John Wiley &amp; Sons Ltd.
Analysis of operating strategies in test/repair areas (1991)

Abstract When a manufacturing environment involves test/repair cycles (until the product is judged defect free), many operating strategies affect the overall performance as measured by the service level, required capacity and safety stock. These relationships, in turn, depend on the process parameters like yield, set up time and product mix. In this paper, we develop a simple model to express these relationships and bring out underlying tradeoffs. We also quantify the advantages of the additional flexibility afforded by reduced setup times. Finally, we evaluate the contribution of the test/repair area to the overall variability of the manufacturing interval under various demand patterns and scheduling strategies.
Nanoionic Resistive Switching Memories: On the Physical Nature of the Dynamic Reset Process (2015)

Resistive switching memories based on the valence change mechanism have attracted great attention due to their potential use in future nanoelectronics. The working principle relies on ion migration in an oxide matrix and subsequent nanoscale redox processes leading to a resistance change. While switching from a low resistive to a high resistive state, different intermediate resistance levels can be programmed by changing the maximum applied voltage, making resistive switches highly interesting for multibit data storage and neuromorphic applications. To date, this phenomenon, which is known as gradual reset, has been reported in various experimental studies, but a comprehensive physical understanding of this key phenomenon is missing. Here, a combined experimental and numerical modeling approach is presented to address these issues. Time‐resolved pulse measurements are performed to study the reset kinetics in TaO x ‐based nano‐crossbar structures. The results are analyzed using a 2D dynamic model of nonisothermal drift–diffusion transport in the mixed electronic–ionic conducting oxide including the effect of contact potential barriers. The model accurately describes the experimental data and provides physical insights into the processes determining the gradual reset. The gradual nature can be attributed to the temperature‐accelerated oxygen‐vacancy motion being governed by drift and diffusion processes approaching an equilibrium situation.
Methods and devices for fabricating and assembling printable semiconductor elements (2023)

The invention provides methods and devices for fabricating printable semiconductor elements and assembling printable semiconductor elements onto substrate surfaces. Methods, devices and device components of the present invention are capable of generating a wide range of flexible electronic and optoelectronic devices and arrays of devices on substrates comprising polymeric materials. The present invention also provides stretchable semiconductor structures and stretchable electronic devices capable of good performance in stretched configurations.
Developing bulk exchange spring magnets (2023)

A method of making a bulk exchange spring magnet by providing a magnetically soft material, providing a hard magnetic material, and producing a composite of said magnetically soft material and said hard magnetic material to make the bulk exchange spring magnet. The step of producing a composite of magnetically soft material and hard magnetic material is accomplished by electrophoretic deposition of the magnetically soft material and the hard magnetic material to make the bulk exchange spring magnet.
Granulocyte-macrophage colony-stimulating factor antagonizes the transforming growth factor-beta-induced expression of Fc gamma RIII (CD16) on human monocytes. (1996)

Fc-gamma receptor III (Fc gamma RIII, CD16) type A is expressed on natural killer cells, on a small subset of peripheral blood monocytes and on mature macrophages. Along with differentiation into macrophages, monocytes will express Fc gamma RIII when cultured with transforming growth factor-beta (TGF-beta). In view of the involvement of granulocyte-macrophage colony-stimulating factor (GM-CSF) in myeloid cell differentiation, we investigated the effect of this cytokine on Fc gamma RIII expression in cultures of peripheral blood monocytes. GM-CSF antagonized TGF-beta-induced expression of Fc gamma RIII on monocytes in vitro in a dose-dependent way. The effect of GM-CSF persisted in cultures until at least day 7. The suppression was at the mRNA level, as shown by Northern analyses with a CD16 specific probe, and the signalling pathway involved tyrosine kinase activity. Interferon-gamma and interleukin-2 had no effect on the induced expression of Fc gamma RIII by TGF-beta, while interleukin-4, similar to GM-CSF, antagonized this induction. Our findings suggest that regulatory cytokine networks can drive monocytes into different effector functions and differentiation pathways.
Effects of anaesthesia on the nitrergic pathway during the micturition reflex in rats (2007)

These results indicate that spinal NO release facilitates the mechanoceptive C-fibres, and this facilitatory effect is masked by supraspinal (possibly forebrain) and local inhibitory effects of NO during the micturition reflex in awake rats. Urethane seems to inhibit the supraspinal and local inhibitory effects of NO, resulting in unmasking the facilitatory effect of NO in the spinal cord and brain stem. During the voiding phase, urethral relaxation depends on the peripheral but not the central NO system.