gebhart/patrepeval huggingface dataset:
Probabilistic design approach for integrated passive devices in RF applications (2008)

This paper presents a new approach to designing robust circuits implementing integrated passive devices (IPD) for radio frequency applications fabricated with thin film technology. IMEC's thin film rf-IPD technology allows defining high-accuracy and high-Q passive components, e.g. transmission lines, inductors, resistors and various types of capacitors, in a cost-effective process. This paper uses a case study based on electrical characterization data for a LC tank based filter using Ta <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> and BCB dielectrics. The effect of the variations in the fabrication process on the performance of the filter and the resulting feedback to the manufacturing of the RF - IPDs is studied. Deterministic approaches are unable to take into account actual variability in design and manufacturing without over-dimensioning the design or assuming a too pessimistic view on the actual characteristics. The probabilistic design approach can be used to align the design with the realistic manufacturing tolerances so that the final design will be always reliable for the given processing variations.
Sol‐Gel Entrapped Pyridinium Hydrobromide Perbromide as a Recyclable Bromination Agent: Its Application to a One‐Pot Bromination and Dehydrobromination Process. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
ChemInform Abstract: Functionalization of Corroles: Formylcorroles. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Figure S6 from Neuregulin 1 Allosterically Enhances the Antitumor Effects of the Noncompeting Anti-HER3 Antibody 9F7-F11 by Increasing Its Binding to HER3 (2023)

&lt;p&gt;Supplemental Fig.S6. Effect of NRG1 on cell viability of the cancer cell lines BxPC3, HCC-1806, A549 and HPAC. Cells were plated in medium with 1% fetal calf serum and then cultured with increasing concentrations of NRG1 for 5 days. Cell proliferation was measured using the MTS assay.&lt;/p&gt;
Integrated low-voltage converter architecture with ac power delivery (2012)

Future computation systems pose a major challenge in energy delivery that is difficult to meet with existing devices and design strategies. To reduce interconnect bottlenecks and enable more flexible computation and energy utilization, it is desired to deliver power across the interconnect to the chip at high voltage and low current with on- or over-die transformation to low voltage and high current. This paper presents an integrated converter architecture with ac voltage transformation to provide very-high-frequency, low-voltage integrated power delivery.
Protein kinase inhibitors selectively block phorbol ester- or forskolin- induced changes in excitability of Aplysia neurons (1989)

Exposure of the bag cell neurons of Aplysia to activators of protein kinase C, such as phorbol esters, enhances electrically evoked action potentials by increasing the voltage-dependent calcium current. We have hypothesized that this effect is mediated by the activation of protein kinase C (PKC). An important prediction of this hypothesis is that inhibitors of PKC should inhibit these phorbol ester-induced changes in bag cell neuronal excitability. We have now found that treatment of bag cell neurons with the protein kinase inhibitor 1-[5-isoquinolinesulfonyl]-2-methyl piperazine (H-7) inhibits the phorbol ester-induced enhancement of bag cell action potentials and prevents the enhancement of calcium current by phorbol esters. The height and width of electrically evoked action potentials in bag cell neurons can also be enhanced by cAMP analogs or agents that elevate cAMP. These agents do not influence the major voltage-dependent calcium current in the bag cell neurons but may act by modulating potassium currents and other voltage-dependent currents. We have found that microinjection of a protein inhibitor of cAMP-PK (PKA-I) into isolated bag cell neurons prevents and reverses the effect of the adenylate cyclase activator forskolin on action potentials of these cells. In contrast, H-7 does not inhibit the effects of forskolin on a variety of responses in these cells, including its effects on action potentials, granule movement, and 32P incorporation into phosphoproteins. This suggests that H-7 is selective for PKC relative to cAMP-PK in intact bag cell neurons.
Blasted Cell Line Names (2010)

A simple application of the Needleman-Wunsch global sequence alignment algorithm provides a useful first pass at matching sample names from different data sets.
Deep, Broad Null Formation for Canceling Moving RFI in Radio Astronomical Arrays (2018)

Radio frequency interference (RFI) is rapidly becoming a major issue for many applications. It is especially problematic for radio astronomy, where signal-to-noise ratios (SNRs) are less than unity. Antenna array systems such as phased array feeds (PAFs) and interferometric imaging arrays are able to cancel RFI through adaptive projection-based spatial notch filtering techniques. Current methods for formulating these projection operators suffer from an unfortunate trade-off. They must sacrifice integration time when calculating the sample spatial correlation matrix in order to track RFI motion, but this consequently increases sample estimation error and reduces null depth. In this work, we propose a new way to process spatial correlation matrices to form a broad null that reliably cancels moving RFI without increasing sample estimation error due to insufficient integration. Additionally, when assisted by an RFI-tracking auxiliary antenna, this approach also reduces the total data rate coming out of a spatial correlator, thus making broad-null-based RFI cancelation more computationally efficient and practical for real-time active array-based RFI mitigation systems.
ChemInform Abstract: Synthesis of Oxetanocin (I). (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Applier tool for intradural spinal cord implants (2012)

We have designed, built and tested a novel device for placing intradural neurmodulator implants directly on the pial surface of the spinal cord. This applier tool is designed for ergonomic handling of delicate electro-mechanical devices such as the Iowa-Patch™ spinal cord stimulator implant, which is aimed at overcoming certain shortcomings in the performance of standard epidural stimulator devices. The applier is approximately 14 cm long, 6 mm in diameter, made of stainless steel components, and has simple and reliable mechanisms for the attachment and release of the implant from it. We describe the design of the device, details of its construction, and its performance during in vivo testing of somatosensory evoked potentials in an ovine model of intradural spinal cord stimulation.
Taste and mouthfeel assessment of porous and non-porous silicon microparticles (2012)

Unlike the trace minerals iron, copper and zinc, the semiconductor silicon has not had its organoleptic properties assessed. Nanostructured silicon provides the nutrient orthosilicic acid through hydrolysis in the gastrointestinal tract and is a candidate for oral silicon supplements. Mesoporous silicon, a nanostructured material, is being assessed for both oral drug and nutrient delivery. Here we use taste panels to determine the taste threshold and taste descriptors of both solid and mesoporous silicon in water and chewing gum base.Comparisons are made with a metal salt (copper sulphate) and porous silica. We believe such data will provide useful benchmarks for likely consumer acceptability of silicon supplemented foodstuffs and beverages.
Molecular probes for muscarinic receptors: derivatives of the M1-antagonist telenzepine (1992)

Functionalized congeners of the M1-selective muscarinic antagonist telenzepine (4,9-dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H- thieno[3,4-b][1,5]benzodiazepin-10-one) were developed and found to bind to the receptor with affinities (Ki values) in approximately the nanomolar range. The derivatives contain a 10-aminodecyl group, which provides a nucleophilic functionality for further derivatization. The attachment of a spacer chain to the distal piperazinyl nitrogen was based on previous findings of enhanced affinity at muscarinic receptors in an analogous series of alkylamino derivatives of pirenzepine [J. Med. Chem. (1991) 34, 2133-2145]. The telenzepine derivatives contain prosthetic groups for radioiodination, protein cross-linking, photoaffinity labeling, and fluorescent labeling and biotin for avidin complexation. The affinity for muscarinic receptors in rat forebrain (mainly m1 subtype) was determined in competitive binding assays vs [3H]-N-methylscopolamine. A (p-aminophenyl)-acetyl derivative for photoaffinity labeling had a Ki value of 0.29 nM at forebrain muscarinic receptors (16-fold higher affinity than telenzepine). A biotin conjugate displayed a Ki value of 0.60 nM at m2-receptors and a 5-fold selectivity versus forebrain. The high affinity of these derivatives makes them suitable for the characterization of muscarinic receptors in pharmacological and spectroscopic studies, for peptide mapping, and for histochemical studies.
3D myocardial T1 mapping at 3T using variable flip angle method: Pilot study (2013)

Myocardial 3D T1 mapping using the variable flip angle approach can potentially be useful for evaluating fibrosis on the entire myocardium using a standard clinical sequence.
Rate-Distortion Bounds for Sparse Approximation (2007)

Sparse signal models arise commonly in audio and image processing. Recent work in the area of compressed sensing has provided estimates of the performance of certain widely-used sparse signal processing techniques such as basis pursuit and matching pursuit. However, the optimal achievable performance with sparse signal approximation remains unknown. This paper provides bounds on the ability to estimate a sparse signal in noise. Specifically, we show that there is a critical minimum signal-to-noise ratio (SNR) that is required for reliable detection of the sparsity pattern of the signal. We furthermore relate this critical SNR to the asymptotic mean squared error of the maximum likelihood estimate of a sparse signal in additive Gaussian noise. The critical SNR is a simple function of the problem dimensions.
A Survey of Anonymity of Cryptocurrencies (2019)

The concept of virtual currencies is an emerging, and perhaps unexpected development in the modern financial world. Bitcoin can be regarded as the first successful virtual currency, followed by many other implementations. Analogous to paper currencies, it is apparent that privacy and anonymity are two pivotal considerations that affect the adoption of virtual currencies by users. However, many studies have identified several problems associated with the privacy and anonymity of Bitcoin. Consequently, a large number of attempts have been made to address these issues, yet it has been proven that many such solutions do not provide an acceptable level of anonymity. This survey presents an account of the level of anonymity achieved through those and attempts to provide a comparative evaluation across different constructions.
Detection of Simian Immunodeficiency Virus Gag-Specific CD8+T Lymphocytes in Semen of Chronically Infected Rhesus Monkeys by Cell Staining with a Tetrameric Major Histocompatibility Complex Class I-Peptide Complex (1999)

Evaluation of human immunodeficiency virus type 1-specific mucosal cytotoxic T lymphocytes can be hampered by limited cell yields from mucosal sites. We sought to characterize virus-specific CD8(+) T lymphocytes with cytotoxic activity in the male genital tracts of SIVmac-infected rhesus monkeys by using a peptide epitope-specific functional T-cell assay and a tetrameric major histocompatibility complex class I-peptide complex. This tetrameric complex was constructed with the rhesus monkey HLA-A homolog molecule Mamu-A*01 and a dominant-epitope 9-amino-acid fragment of SIVmac Gag (p11C, C-M). The proportion of tetramer-positive CD8(+) T cells in semen of SIVmac-infected monkeys ranged from 5.9 to 22.0%. By the use of a standard 51Cr release assay, these cells were found to have peptide epitope-specific cytolytic activity after in vitro expansion. Four-color flow-cytometric analysis of these seminal tetramer-positive CD8(+) T cells demonstrated that they express memory-associated (CD62L- CD45RA-) and activation-associated (CD11a+ Fas+ HLA-DR+) molecules. The present experiments illustrate the power of tetramer technology for evaluating antigen-specific CD8(+) T lymphocytes in a mucosal tissue compartment.
ChemInform Abstract: SYNTHESIS OF 6,14‐ETHENOISOMORPHINANS AND 6,14‐ETHENOMORPHINANS BASED ON DIELS‐ALDER ADDUCTS OF 6‐DEMETHOXYTHEBAINE AND 6‐DEMETHOXY‐β‐DIHYDROTHEBAINE; PHARMACOLOGY OF THE ISOMORPHINANS (CHEMISTRY OF OPIUM ALKALOIDS, PART XIX) (1985)

Abstract Die aus natürlichem (‐ )‐Codein erhaltene Verbindung (I) wird über die Addukte (Va) (Syntheseweg bekannt) bzw. (Vb) in die Verbindungen (Vc)‐(Vg) bzw. (VI) übergeführt.
In situ ellipsometry aided rapid ALD process development and parameter space visualization of cerium oxide nanofilms (2021)

Process development in atomic layer deposition (ALD) is often time-consuming, requiring optimization of saturation curves and temperature windows for controlled deposition rates. Any ALD process should be self-limiting in nature, exhibiting a temperature window of nominal deposition and a linear deposition rate. Meeting these criteria usually requires several ALD experiments, followed by film characterization, which are generally time, cost, and labor-intensive. Against this backdrop, we report a methodology using in situ ellipsometry to rapidly develop the ALD process for cerium oxide using Ce(iPrCp)2(N-iPr-amd) and water. The entire optimized process was realized in ten experiments of sequential pulsing as a function of temperature, requiring less than a day. In the traditional approach, tens of experiments and ex situ characterization may be required. The approach reported here generated a contour visualization of the time-temperature-thickness parameter space delineating the optimal deposition conditions. The cerium oxide deposition rate deposited in the ALD temperature window was ∼0.15 nm/cycle; the deposited film was further characterized using x-ray photoelectron spectroscopy, x-ray diffraction, and atomic force microscopy to probe the film composition and quality further.
Supplementary Figure 4 from Cancer-Associated Adipose Tissue Promotes Breast Cancer Progression by Paracrine Oncostatin M and Jak/STAT3 Signaling (2023)

&lt;p&gt;Graphs representing relative mRNA levels of OSMR, LIFR, GP130 and STAT3 in MCF-7 and SKBR3 cells treated for 48h with control medium or rhOSM (2 ng/ml).&lt;/p&gt;
Supplementary Figure Legend from Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection (2023)

Supplementary Figure Legend from Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection
Screening Techniques for Selecting Improved Additives for Bottom-Up Copper Metallization (2013)

Abstract not Available.
Abstract 556: Cot/Tpl2 is required for neoplastic cell transformation induced by interleukin-22: a possible mechanism in breast carcinogenesis. (2013)

Abstract Interleukin 22 (IL-22), a member of the IL-10 family of cytokines, is secreted T helper 17 (Th17) cells. Although IL-22 was recently reported to be a novel inflammation mediator through STAT3 signaling activation, the precise mechanisms of IL-22 in neoplastic cellular transformation and breast carcinogenesis are not well explored yet. Here, we report that IL-22 induced neoplastic transformation of JB6 Cl41 cells through activation of Cot/Tpl2. IL-22 dose- and time-dependently increased Cot/Tpl2 phosphorylation in JB6 Cl41 cells through IL-22 receptor. IL-22 phosphorylated MEK1/2, JNK1/2 and STAT3, which were inhibited by a specific inhibitor of Cot/Tpl2 kinase. When small interfering RNA (siRNA) of IL-22 and IL-22 receptor (IL-22R) were transfected into JB6 Cl41 cells, IL-22-induced Cot/Tpl2 phosphorylation was markedly decreased, followed by inhibition of MEK-ERK, JNK-c-Jun and STAT3 signaling pathway. Also, IL-22 activated c-fos and c-jun promoter activity, leading to increased activator protein-1 (AP-1) activity, which was suppressed by Cot/Tpl2 inhibitor. The in vivo chorioallantoic membrane (CAM) assay also showed that IL-22 increased tumor growth of JB6 Cl41 cells, whereas Cot/Tpl2 inhibitor suppressed the tumorigenesis induced by IL-22. In addition, knockdown of IL-22 and/or inhibition of Cot/Tpl2 diminished tumorigenecity of human breast cancer SKBR3 cells. Consistent with these observations, immunohistochemical staining showed that both expressions of IL-22 and Cot/Tpl2 proteins were highly upregulated in human breast cancers. Thus, this suggests that Cot/Tpl2 plays a pivotal role in IL-22-induced neoplastic cell transformation, and that Cot/Tpl2 may be the therapeutic target of breast cancer promoted by IL-22. Citation Format: Karam Kim, Hong Seok Choi. Cot/Tpl2 is required for neoplastic cell transformation induced by interleukin-22: a possible mechanism in breast carcinogenesis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 556. doi:10.1158/1538-7445.AM2013-556 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
An investigation into traffic analysis for diverse data applications on smartphones (2012)

Present day smartphones like iPhone and Andriod based phones have lead to explosive growth in traffic over cellular networks. The growth has occurred both in volume and diversity in terms of traffic characteristics. Among the different types of traffic, there is prominent increase in background type of data due to popularity of applications like Facebook, Skype, Email clients etc which keeps exchanging data with corresponding server, even when the user is not actively using the application. In order to save power consumption of smart phones and for optimal allocation of resources to deserving phones in network by minimum possible signaling traffic, 3GPP LTE specifications have defined mechanisms like connected mode DRX (Discontinuous Reception) which offers two stage of sleep in form of long & short DRX. Since such diverse type of applications are running in smartphone, this work attempts to investigate traffic characteristics of popular applications in Andriod based smartphones. Due to various reasons, such applications, keep consuming precious bandwidth and battery even when not in active use. Main emphasis is thus provided to study the characteristic of these applications when they are running without user intervention. Since, the diverse range of data characteristics is assumed to be causing drain in User Equipment (UE) battery and overhead in NW signaling, we expect that this investigation would help in developing appropriate new power saving mechanisms in future releases of cellular networks.
ChemInform Abstract: SYNTH. 3,3‐DISUBSTITUIERTER 2‐ARYL‐ACRYLSAEUREN (1971)

Abstract Durch Wittig‐Reaktion der Arylglyoxylsäureester(I) mit Isopropylidentriphenylphosphoran (aus Isopropyltriphenylphosphoniumbromid und Butyl‐Li) in n‐Hexan/Tetrahydrofuran bei 0‐25°C [oder auch durch Reaktion von 3‐Aryl‐3‐hydroxy‐2,2‐dimethyl‐propionsäureestern mit P(V)‐oxid] werden die Croton‐säureester (II) (Ausbeute 10‐81%), daraus durch Hydrolyse in siedendem Wasser‐Essigsäure‐HCl (zum Teil auch in siedendem Methanol‐KOH) die Croton‐säuren (III) (23‐79%) dargestellt.
Hereditary cancer risk assessment in the community urology practice setting. (2022)

278 Background: Professional guidelines recommend hereditary cancer risk assessment (HCRA) for men with prostate cancer to inform both risk of cancer (primary or subsequent) and treatment decisions. The objectives of the study were to evaluate the feasibility of integrating a HCRA protocol in urology practice for patients with prostate cancer and determine the response of providers and patients to the HCRA protocol. Methods: This prospective study was divided into 4 segments: process integration (4 wks.), practice (4 wks.), post-integration (8 wks.), and follow up (10 wks.). Study site staff were trained to perform HCRA for men with prostate cancer (integration). The sites then incorporated recommendations from the integration process into their normal practice workflow (practice). During the post-integration period, the HCRA process was implemented with eligible patients consented to participate. Eligible patients were ≥18 years old, had a personal history of prostate cancer, and met National Comprehensive Cancer Network guidelines for genetic testing (2.2018). Patients and providers completed surveys regarding testing ≥ 8 weeks of test delivery or 1 week of end of data collection period, respectively (follow up). Results: In the 8 weeks prior to the study, 4.2% of patients completed testing at the study sites. During the study, 8.4% of patients completed testing, about 1/2 of eligible patients screened. Of all patients who completed testing and consented for their results to be summarized (N = 182), 10.4% (N = 19) tested positive for a single pathogenic variant (PV; monoallelic MUTYH N = 4; BRCA2 N = 3; ATM, BRCA1, BRIP1, CHEK2, HOXB13 N = 2 each; RAD51C, RAD51D N = 1 each). Not all men who tested positive or a PV reported a family history of cancer and not all PVs detected were in known prostate cancer risk genes. During follow up, most providers (61.0%) felt HCRA was as important as other assessments regularly performed and 68.3% planned to continue to use the HCRA process. In contrast, only 9.8% of providers did not believe HCRA was as important and 12.2% did not plan to continue to use the process. Of the patients that responded to the survey (N = 166), most had shared (62.0%) or planned to share (25.3%) their results with family members post-testing. Conclusions: Urologists and patients responded favorably to HCRA protocol integration. Based on this study, education around and incorporation of an HCRA process in a community urology practice setting for men with prostate cancer appears effective at increasing appropriate uptake of genetic testing. Clinical trial information: NCT04015102.