gebhart/patrepeval huggingface dataset:
Benzyl Vinylogous Amide Substituted Aryldihydropyridazinones and Aryldimethylpyrazolones as Potent and Selective PDE3B Inhibitors. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Poly(naphthalenediimidequaterthiophene):Poly(hexyilthiophene) Heterojunctions. Efficient Polymer-to-Polymer Electron Transfer Interfaces (2013)

Organic thin films solar cells and plastic solar cells [1] have attracted the attention of the scientific community especially as regards the performance of new conjugated polymers including their interfaces [2-4]. In this work, poly(naphthalenediimidequaterthiophene) (PNDIT4) and poly(hexyilthiophene) (P3HT) have been employed, for the first time, for engineering planar and bulk heterojunctions by the synergetic use of two techniques: electropolymerization and layer by layer deposition. Electropolymerization has been used for obtaining PNDIT4 thin films on transparent ITO/PET electrodes, starting from the synthesized monomer. Inverse Langmuir-Schaefer technique has been employed for depositing P3HT on ITO/PET supported PNDIT4 electrodes. Both the techniques allow an accurate control of the films thickness and XPS as well as contact angle have been performed to investigate the thin film chemistry and interfacial tension. Bulk heterojunctions have been obtained by the thermal annealing at 130°C of planar heterojunctions. SEM and AFM analyses have evidenced the morphological structure of the mixed polymeric blends. Steady state fluorescence studies have been performed in order to investigate the electron transfer efficiency in these two device configurations. Planar architectures displayed a fluorescence quenching of 67% while bulk heterojunctions showed a fluorescence quenching as high as 98% suggesting an efficient electron transfer from the excited P3HT to PNDIT4 The high values of quenching percentage can be attributed to the synergic effect of the following factors: suitable domain size and film thickness of the two polymeric phases; appropriate energy levels location as confirmed by cyclic voltammetry, UV-Vis spectra and DFT calculations. The relevant performance of such polymer-polymer interface is here studied also through the development of plastic solar cells.
A monostatic antenna-reflector system for ultra-short-range radar applications (2013)

In this contribution, a novel antenna-reflector system is introduced, which consists of a planar waveguide orthomode transducer, a lens-horn antenna and a transpolarizing reflector. The proposed antenna system eliminates short-range clutter effects like root point reflections and antenna ringing effectively. The setup enables ultra-short-range radar measurements as they are used e.g. for material characterization measurements. Results of 3D-electromagnetic field simulations as well as measurements, that prove the effectiveness of the antenna setup are shown and discussed in detail.
Polymers designed to control nucleation and growth of inorganic crystals from aqueous media (2001)

Water soluble graft polymers prepared by copolymerization of either methacrylic acid (MAA) or vinylsulfonic acid (VS) with α-methoxy-ω-methacroyl-oligo(oxyethylene)s (PEOn-MA) serve to control nucleation and crystal growth during precipitation of inorganic crystals from aqueous media. Precipitation of zinc oxide crystals (‘zincite’) is used as example for such mineralization processes. Homogeneous and narrow crystal size distributions are obtained in presence of ppm-amounts of graft copolymers. Copolymer is incorporated into the crystals demonstrated by using latex particles with -CO2H-group rich surfaces as controlling additives. Incorporation of these particles leads to single crystals with pores of the size of the particles (‘Swiss cheese’ morphologies).
Isolation and Identification of Compounds from Brazilian Propolis which Enhance Macrophage Spreading and Mobility. (1996)

Brazilian propolis is known to induce the activation of murine effector cells. We isolated and identified six compounds from a water-soluble extract of Brazilian propolis, all of which have enhancing effects on the spreading and mobility of murine macrophages. These compounds were identified as caffeoylquinic acid-derivatives, namely, 5-caffeoylquinic acid (1), chlorogenic acid (2), 4-caffeoylquinic acid (3), 4,5-dicaffeoylquinic acid (4), 3,5-dicaffeoylquinic acid (5) and 3,4-dicaffeoylquinic acid (6).
Orthotic Heel Wedges Do Not Alter Hindfoot Kinematics and Achilles Tendon Force During Level and Inclined Walking in Healthy Individuals (2015)

Conservative treatments such as in-shoe orthotic heel wedges to treat musculoskeletal injuries are not new. However, weak evidence supporting their use in the management of Achilles tendonitis suggests the mechanism by which these heel wedges works remains poorly understood. It was the aim of this study to test the underlying hypothesis that heel wedges can reduce Achilles tendon load. A musculoskeletal modeling approach was used to quantify changes in lower limb mechanics when walking due to the introduction of 12-mm orthotic heel wedges. Nineteen healthy volunteers walked on an inclinable walkway while optical motion, force plate, and plantar pressure data were recorded. Walking with heel wedges increased ankle dorsiflexion moments and reduced plantar flexion moments; this resulted in increased peak ankle dorsiflexor muscle forces during early stance and reduced tibialis posterior and toe flexor muscle forces during late stance. Heel wedges did not reduce overall Achilles tendon force during any walking condition, but did redistribute load from the medial to lateral triceps surae during inclined walking. These results add to the body of clinical evidence confirming that heel wedges do not reduce Achilles tendon load and our findings provide an explanation as to why this may be the case.
COMT: A common susceptibility gene in bipolar disorder and schizophrenia (2004)

A variety of psychiatric illnesses, including schizophrenia and bipolar disorder, have been reported in patients with microdeletion on chromosome 22q11-a region which includes the catechol-O-methyltransferase (COMT) gene. The variety of psychiatric manifestations in patients with the 22q11 microdeletion and the role of COMT in the degradation of catecholamine neurotransmitters may thus suggest a general involvement of the COMT gene in psychiatric diseases. We have previously reported on a significant association between a COMT haplotype and schizophrenia. In this study, we attempt to test for association between bipolar disorder and the polymorphisms implicated in schizophrenia. The association between COMT and bipolar disorder was tested by examining the allele and haplotype found to be associated with schizophrenia. A significant association between bipolar disorder and COMT polymorphisms was found. The estimated relative risk is greater in women, a result consistent with our previous findings in schizophrenia. We suggest that polymorphisms in the COMT gene may influence susceptibility to both diseases--and probably also a wider range of behavioral traits.
111. SURGICAL TREATMENT OF ANTERIOR INSTABILITY IN RUGBY PLAYERS: CLINICAL AND RADIOLOGICAL RESULTS OF THE LATARJET-PATTE PROCEDURE WITH MINIMUM FIVE YEARS FOLLOW-UP (2011)

Purpose of the study: The purpose of this study was to report the clinical and radiographic outcomes a minimum five years after Latarjet-Patte treatment for recurrent traumatic anterior instability of the shoulder in rugby players. It was hypothesised that the Latarjet-Patte procedure fulfils the needs for shoulder stability in rugby players with anterior instability. Material and methods: Thirty-four players (37 shoulders) were included. Mean age was 23.4 years (17–33). A bone lesion of the glenoid was noted in 73% of the shoulders, a humeral defect in 68%. Results: Mean follow-up was 144 months (range 68–237). There was no recurrence (dislocation or subluxation). Apprehension persisted in five patients (14%). Sixty-five percent of the patients resumed playing rugby. Only one patient interrupted his sports activities because of the operated shoulder. The Walch-Duplay and Rowe scores were 86 and 93 points on average. The satisfaction rate was 94%. The block healed in 89% of shoulders (3 fractures, 1 nonunion). Twenty-six shoulders (70%) were free of degenerative disease, 11 shoulders (30%) presented stage 1 lesions. Discussion: In rugby players, anterior instability exhibits characteristic bone lesions of the humerus and glenoid which can be identified as risk factors for recurrent instability. The Latarjet-Patte procedure provides a stable shoulder allowing resumption of rugby player for most patients with no long-term degradation of the shoulder joint. These results are in favour of our strategy to propose the coracoids block systematically for recurrent anterior instability in rugby players.
Robustezza della tecnica time-interleaving nei sistemi 100-Gb/s POLMUX RZ-DQPSK in presenza di PDL (2010)

Contrary to what happens with PMD, time-interleaving in 100-Gb/s POLMUX RZ-DQPSK is found to feature a strong robustness to PDL and even in presence of optical narrow filtering proves the best solution against PDL issue.
Photochemistry on soft-glass hollow-core photonic crystal fibre (2014)

Hollow-core photonic crystal fibre (HC-PCF) offers strong light confinement and long interaction lengths in an optofluidic channel. These unique advantages have motivated its recent use as a highly efficient and versatile microreactor for liquid-phase photochemistry and catalysis. In this work, we use a soft-glass HC-PCF to carry out photochemical experiments in a high-index solvent such as toluene. The high-intensity and strong confinement in the fibre is demonstrated to enhance the performance of a proof-of-principle photolysis reaction.
Towards continuous policy-driven demand response in data centers (2011)

Demand response (DR) is a technique for balancing electricity supply and demand by regulating power consumption instead of generation. DR is a key technology for emerging smart electric grids that aim to increase grid efficiency, while incorporating significant amounts of clean renewable energy sources. In today's grid, DR is a rare event that only occurs when actual peak demands exceed the expected peak. In contrast, smart electric grids incentivize consumers to engage in continuous policy-driven DR to 1) optimize power consumption for time-of-use pricing and 2) deal with power variations from non-dispatchable renewable energy sources. While data centers are well-positioned to exploit DR, applications must cope with significant, frequent, and unpredictable changes in available power by regulating their energy footprint.
Ab Interno Trabeculectomy With a Dual Blade: Surgical Technique for Childhood Glaucoma (2017)

This was a successful, minimally invasive procedure for treatment of childhood glaucoma.
Human Herpesvirus 8 in the Prostate Glands of Men with Kaposi’s Sarcoma (1998)

The epidemiology of human immunodeficiency virus (HIV)-associated Kaposi's sarcoma (KS) resembles that of a sexually transmitted pathogen. However, human herpesvirus 8 (HHV-8), the proposed cause of KS, is found in semen only infrequently and at low titers. To determine whether HHV-8 was present in the urogenital tract, transrectal ultrasound-guided prostate biopsies were obtained from six men with KS (five with concurrent HIV infection) and four without KS (three with concurrent HIV) and assayed for HHV-8 by PCR. Nine of the 10 men were seropositive for HHV-8. Five of nine HHV-8-seropositive men had HHV-8 DNA detected in prostate tissue by solution-based PCR. All five currently had KS or had it previously. In two subjects, prostate tissue was the only identified source of HHV-8. In situ PCR on serial sections of prostate indicated that HHV-8 infection was localized to discrete areas of the prostate. When detected, HHV-8 DNA was present in the nuclei of >90% of the glandular epithelial cells. In situ hybridization for HHV-8 mRNA revealed that between 1 and 5% of cells harboring HHV-8 DNA expressed viral transcripts associated with HHV-8 replication (T1.1 transcript), while >90% expressed gene products associated with viral latency (T0.7 transcript). Intermittent replication of HHV-8 in the prostate and subsequent shedding of virus in semen may be crucial factors for determining whether HHV-8 can be transmitted through sexual activity.
Detection of point mutations in human DNA by analysis of RNA conformation polymorphism(s) (1992)

RNA molecules were found to separate into numerous metastable conformational forms upon non-denaturing gel electrophoresis. The equilibration of the conformations was accelerated by heating or mild denaturing conditions. Single-base substitutions in the sequence of the RNAs caused changes in the conformational patterns, including mobility shifts of major and minor conformations, appearance of new conformations and loss of other conformations. This sequence-dependent RNA conformational polymorphism was used to detect point mutations in p53 and, dihydrofolate reductase genes. Sense and anti-sense RNA strands corresponding to the same segment of the p53 gene gave entirely different conformational patterns. To generate the RNA, short regions of the target genes (up to about 250 bp) were amplified by the polymerase chain reaction and the resulting DNA segments transcribed to RNA by T7 RNA polymerase. The method is rapid, simple, amenable to non-radioactive visualization and was successful in several cases when DNA single-strand conformational polymorphism analysis (Orita et al. (1989) Genomics 5, 874-879) failed to detect the point mutation.
Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and ω-Hydroxylases (2017)

Cytochromes P450 metabolize arachidonic acid (AA) into two vasoactive oxylipins with opposing biologic effects: epoxyeicosatrienoic acids (EETs) and omega-(ω)-terminal hydroxyeicosatetraenoic acids (HETEs). EETs have numerous beneficial physiological effects, including vasodilation and protection against ischemia/reperfusion injury, whereas ω-terminal HETEs induce vasoconstriction and vascular dysfunction. We evaluated the effect of these oxylipins on post-ischemic vasodilation known as coronary reactive hyperemia (CRH). CRH prevents the potential harm associated with transient ischemia. The beneficial effects of EETs are reduced after their hydrolysis to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). ω-terminal HETEs are formed by ω-hydroxylase family members. The relationship among endothelial over-expression of sEH (Tie2-sEH Tr), the changes in oxylipins it may produce, the pharmacologic inhibition of ω-hydroxylases, activation of PPARγ, and CRH response to a brief ischemia is not known. We hypothesized that CRH is attenuated in isolated mouse hearts with endothelial sEH over-expression through modulation of oxylipin profiles, whereas both inhibition of ω-hydroxylases and activation of PPARγ enhance CRH. Compared to WT mice, Tie2-sEH Tr mice had decreased CRH, including repayment volume, repayment duration, and repayment/debt ratio (P < 0.05), whereas inhibition of ω-hydroxylases increased these same CRH parameters in Tie2-sEH Tr mice. Inhibition of sEH with t-AUCB reversed the decreased CRH in Tie2-sEH Tr mice. Endothelial over-expression of sEH significantly changed oxylipin profiles, including decreases in DHETs, mid-chain HETEs, and prostaglandins (P < 0.05). Treatment with rosiglitazone, PPARγ-agonist, enhanced CRH (P < 0.05) in both Tie2-sEH Tr and wild type (WT) mice. These data demonstrate that endothelial over-expression of sEH (through changing the oxylipin profiles) attenuates CRH, whereas inhibition of ω-hydroxylases and activation of PPARγ enhance it.
Characteristics of a field plate connected to T-shaped gate in AlGaN/GaN HEMTs (2015)

An AlGaN/GaN high electron mobility transistor (HEMT) with a T-shaped gate employing a gate-foot-connected field plate is presented. Similar to other devices with gate connected field plates the device described in this paper is a variation of the Γ-shaped gate with the “head” of the Tshaped gate attached at the top. The proposed device has a higher breakdown voltage and a lower leakage current due to the attached field plate while maintaining the advantages of the T-shaped gate structure, which are a low gate resistance and a low noise level. In addition, the field plate deposition step during the fabrication process involves a partial covering of the “foot” of the gate which showed a possibility for a gate length reduction.
PATTERNS OF ADENOVIRUS INFECTIONS IN MARINE CORPS PERSONNEL (1964)

Journal Article PATTERNS OF ADENOVIRUS INFECTIONS IN MARINE CORPS PERSONNEL: II. LONGITUDINAL STUDY OF SUCCESSIVE ADVANCED RECRUIT TRAINING COMPANIES Get access BEN R. FORSYTH, BEN R. FORSYTH 2Naval Medical Field Research LaboratoryCamp Lejeune, N. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar H. H. BLOOM, H. H. BLOOM 3Naval Medical Field Research LaboratoryCamp Lejeune, N. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar KARL M. JOHNSON, KARL M. JOHNSON 4Laboratory of Infectious Diseases, NIAID, National Institutes of HealthBethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT M. CHANOCK ROBERT M. CHANOCK 4Laboratory of Infectious Diseases, NIAID, National Institutes of HealthBethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 80, Issue 3, November 1964, Pages 343–355, https://doi.org/10.1093/oxfordjournals.aje.a120484 Published: 01 November 1964
WE‐AB‐BRA‐06: 4DCT‐Ventilation: A Novel Imaging Modality for Thoracic Surgical Evaluation (2016)

Purpose: The current standard‐of‐care imaging used to evaluate lung cancer patients for surgical resection is nuclear‐medicine ventilation. Surgeons use nuclear‐medicine images along with pulmonary function tests (PFT) to calculate percent predicted postoperative (%PPO) PFT values by estimating the amount of functioning lung that would be lost with surgery. 4DCT‐ventilation is an emerging imaging modality developed in radiation oncology that uses 4DCT data to calculate lung ventilation maps. We perform the first retrospective study to assess the use of 4DCT‐ventilation for pre‐operative surgical evaluation. The purpose of this work was to compare %PPO_PFT values calculated with 4DCT‐ventilation and nuclear‐medicine imaging. Methods: 16 lung cancer patients retrospectively reviewed had undergone 4DCTs, nuclear‐medicine imaging, and had Forced Expiratory Volume in 1 second (FEV1) acquired as part of a standard PFT. For each patient, 4DCT data sets, spatial registration, and a density‐change based model were used to compute 4DCT‐ventilation maps. Both 4DCT and nuclear‐medicine images were used to calculate %PPO_FEV1 using %PPO_FEV1=pre‐operative FEV1*(1‐fraction of total ventilation of resected lung). Fraction of ventilation resected was calculated assuming lobectomy and pneumonectomy. The %PPO_FEV1 values were compared between the 4DCT‐ventilation‐based calculations and the nuclear‐medicine‐based calculations using correlation coefficients and average differences. Results: The correlation between %PPO_FEV1 values calculated with 4DCT‐ventilation and nuclear‐medicine were 0.81 (p&lt;0.01) and 0.99 (p&lt;0.01) for pneumonectomy and lobectomy respectively. The average difference between the 4DCT‐ventilation based and the nuclear‐medicine‐based %PPO_FEV1 values were small, 4.1±8.5% and 2.9±3.0% for pneumonectomy and lobectomy respectively. Conclusion: The high correlation results provide a strong rationale for a clinical trial translating 4DCT‐ventilation to the surgical domain. Compared to nuclear‐medicine, 4DCT‐ventilation is cheaper, does not require a radioactive contrast agent, provides a faster imaging procedure, and has improved spatial resolution. 4DCT‐ventilation can reduce the cost and imaging time for patients while providing improved spatial accuracy and quantitative results for surgeons. YV discloses grant from State of Colorado
Video Compressive Sensing for Spatial Multiplexing Cameras Using Motion-Flow Models (2015)

Spatial multiplexing cameras (SMCs) acquire a (typically static) scene through a series of coded projections using a spatial light modulator (e.g., a digital micromirror device) and a few optical sensors. This approach finds use in imaging applications where full-frame sensors are either too expensive (e.g., for short-wave infrared wavelengths) or unavailable. Existing SMC systems reconstruct static scenes using techniques from compressive sensing (CS). For videos, however, existing acquisition and recovery methods deliver poor quality. In this paper, we propose the CS multiscale video (CS-MUVI) sensing and recovery framework for high-quality video acquisition and recovery using SMCs. Our framework features novel sensing matrices that enable the efficient computation of a low-resolution video preview, while enabling high-resolution video recovery using convex optimization. To further improve the quality of the reconstructed videos, we extract optical-flow estimates from the low-resolution previews and impose them as constraints in the recovery procedure. We demonstrate the efficacy of our CS-MUVI framework for a host of synthetic and real measured SMC video data, and we show that high-quality videos can be recovered at roughly $60\times$ compression.
Molecular‐beam epitaxially grown spatial light modulators with charge‐coupled‐device addressing (1988)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation W. D. Goodhue, B. E. Burke, B. F. Aull, K. B. Nichols; Molecular‐beam epitaxially grown spatial light modulators with charge‐coupled‐device addressing. Journal of Vacuum Science & Technology A 1 July 1988; 6 (4): 2356–2360. https://doi.org/10.1116/1.575590 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science & Technology A Search Advanced Search |Citation Search
Selective availability influences on static differential gps surveying (1990)

Speculation regarding possible Global Positioning System accuracy downgrading under a selective availability program has instilled doubt in the minds of many surveying users. This investigation serves to quell unnecessary concern by quantifying the impact of selective availability on static differential carrier phase positioning.
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH (2015)

More than half of human colorectal cancers (CRCs) carry either KRAS or BRAF mutations and are often refractory to approved targeted therapies. We found that cultured human CRC cells harboring KRAS or BRAF mutations are selectively killed when exposed to high levels of vitamin C. This effect is due to increased uptake of the oxidized form of vitamin C, dehydroascorbate (DHA), via the GLUT1 glucose transporter. Increased DHA uptake causes oxidative stress as intracellular DHA is reduced to vitamin C, depleting glutathione. Thus, reactive oxygen species accumulate and inactivate glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Inhibition of GAPDH in highly glycolytic KRAS or BRAF mutant cells leads to an energetic crisis and cell death not seen in KRAS and BRAF wild-type cells. High-dose vitamin C impairs tumor growth in Apc/Kras(G12D) mutant mice. These results provide a mechanistic rationale for exploring the therapeutic use of vitamin C for CRCs with KRAS or BRAF mutations.