Editorial: Cerebrovascular imaging—From micro- to macroscopic scales (2022)

While most of the vascular imaging methods focus on the flowing lumen, vessel wall MRI provides the ability to directly visualize the vessel wall, which is the source of pathology in atherosclerotic plaques, aneurysms and other vasculopathy. Most vessel MRI studies were performed at 3 Tesla due to its high signal to noise ratio (SNR) compared to 1.5 Tesla, and the use of ultra-high field 7 Tesla MRI scanners further increases the ability (1) (2).In this research topic collection, Lei Zhang et al. developed a T2 prepared inversion recovery (IR) MRI sequence (T2IR-SPACE) which markedly suppressed the Cerebrospinal Fluid (CSF) signal without much SNR loss of other tissues (i.e., vessel wall, white matter, and gray matter). Such sequence can be used in multi-contrast intracranial vessel wall imaging to achieve good CSF suppression and improve the vessel wall contrast. Qingle Kong et al developed 3D innervolume (IV) TSE (SPACE) sequence with optimized 2D spatially selective excitation (SSE) radio frequency (RF) pulses, and they achieved the highest resolution (0.3mm isotropic) in vivo vessel wall MRI so far by using a 7T scanner. They found clearer delineation of lumen of lenticulostriate artery (LSA) than conventional SPACE images.Wenjing Xu et al developed automatic segmentation methods for carotid and intracranial plaques on vessel wall MRI in 124 patients using machine learning. Their method demonstrated satisfactory agreement with the manual method, with dice values of 93.8% for lumen contours and 86.0% for outer wall contours, which were higher than those obtained from the traditional U-Net, Attention U-Net, and Inception U-Net. Arjen Lindenholz et al found an interrelationship between large vessel wall lesion burden and cerebral parenchymal manifestations often linked to small vessel disease (SVD). Jia Li et al studied 68 patients with vertebrobasilar atherosclerosis using vessel wall MRI, and found the vertebrobasilar junction (VBJ) angle over 90° might aggravate the vessel wall condition of the atherosclerotic vertebrobasilar arteries, which might serve as a potential risk factor for vertebrobasilar atherosclerosis.Laura Eisenmenger et al presented 9 cases of arteriovenous malformation (AVM) and found Vessel wall "enhancement" occurs in AVMs with no prior clinical rupture. Jiayu Xiao et al presented a case of intracranial plaque with serial vessel wall MRI follow up and they found vessel wall MRI can directly visualize the morphology and signal change of plaques. The suggest early identification of patients who do not respond well to medication is critical to prevent the recurrence of cardiovascular events in these patients.Perfusion imaging plays an important role in the management of patients with neurovascular diseases. Kay Jann et al applied 3D pseudo-continuous arterial spin labeling (pCASL) MRI in the cohort of elderly Latinx subjects and found cerebral blood flow (CBF) in the leptomeningeal and perforator middle cerebral artery (MCA) territories were the most likely candidate biomarker of Vascular Cognitive Impairment and Dementia (VCID). Zhang Shi et al compared several software for CT perfusion measurements and found F-STROKE software had excellent agreement with the widely used analysis tool of RAPID in measuring ischemic core volume (ICV) and penumbra volume (PV). Qinyang Shou et al developed superresolution perfusion imaging and achieved high spatial resolution (isotropic-2 mm) using 2D simultaneous multi-slice (SMS) pseudo-continuous arterial spin labeling (pCASL) and slice dithered enhanced resolution (SLIDER) technique. Till de Bortoli used T2*-weighted imaging and ultra-small superparamagnetic iron oxide nanoparticles to obtain subtraction angiographies and steady-state cerebral blood volume (ss-CBV) maps. They found the maps agreed well with first pass dynamic susceptibility contrast MRI (DSC-MRI). They concluded that iron oxide nanoparticle-based ss-CBV could serve as a robust, non-invasive imaging surrogate marker for neocortical vessels, with the potential to reduce and refine preclinical models targeting the development and outgrowth of cerebral collateralization.Hemodynamics plays important roles in the development and progression of vascular diseases. The hemodynamics information could be either computed using computational fluid dynamics (CFD) by using image-derived geometry or directly acquired by flow imaging. Xiaodong Zhai et al performed CFD analysis in 20 unruptured and 12 ruptured pericallosal artery aneurysms (PAA) with 3D digital subtraction angiography (DSA), and found a high mean oscillatory shear index (OSI) was an independent risk factor for PAA rupture. Guiling Zhang et al studied the hemodynamics using 4D flow MRI and found increased wall shear stress (WSS), especially during the diastolic period and in the axial direction, may be a sign for a high-risk plaque and may cause cerebrovascular events in patients with moderate carotid artery stenosis.Dongqin Zhu et al studied a total of 632 patients with 668 MCA aneurysms (423 ruptured aneurysms) from five hospitals and quantified their radiomics and morphological features from computed tomography angiography images. They concluded integrating radiomics features into conventional models might provide additional value in ruptured MCA aneurysms classification. Wenjing Xu et al applied deep learning in vessel wall imaging.Martin Bretzner et al analyzed a multi-site cohort of 4163 acute ischemic strokes (AIS) patients with T2-FLAIR MR images with total brain and white matter hyperintensity (WMH) segmentations. They found Radiomics extracted from T2-FLAIR images of AIS patients capture microstructural damage of the cerebral parenchyma and correlate with clinical phenotypes, suggesting different radiographical textural abnormalities per cardiovascular risk profile. Tengfei Li et al found high-resolution flat-detector computed tomography (HR-FDCT) improves visualization of the fine structures of intracranial stents deployed for symptomatic intracranial atherosclerotic stenosis (ICAS) compared with that visualized using conventional flat-detector computed tomography (FDCT). The concluded HR-FDCT improves assessment of stent deployment and could reduce the risk of complications. Heng Du et al reviewed the histological and imaging features of intimal and medial calcification within the large intracranial arteries and highlighted its clinical relevance.Vessel wall imaging is a hot topic with increasing research and clinical translation interests (3) in the past decade and we include seven articles in this collection. However, most of current studies were cross-sectional with limited sample sizes. Future larger scale longitudinal studies and randomized controlled trails are needed to establish vessel wall imaging markers to predict patients' outcome (4). Perfusion imaging with noninvasive ASL techniques continues to grow and translate into clinical use. Hemodynamic conditions in neurovascular disease have been studied for several decades but the clinical utility still need larger scale study to prove. Recent advances in 4D flow imaging with higher resolution and shorter scan time may facilitate its clinical translation. Deep learning is another hot topic in neurovascular imaging recently and it has great potential for image acceleration, reconstruction and automating image analysis.