gebhart/patrepeval huggingface dataset:
Automatic QRS onset and offset detection for body surface QRS integral mapping of ventricular tachycardia (1994)

A QRS onset and offset detection algorithm has been developed for use in body surface QRS integral mapping of ventricular tachycardia. To determine QRS intervals, the algorithm uses two computed signals: the sum of the absolute values of the first derivatives of all leads and the sum of the absolute values of all leads. The second order derivative of the latter parameter is used to detect the time instants of QRS onset and offset. Using the algorithm, QRS integral maps are subsequently computed, which are correlated with a database of QRS integral maps in order to localize the site of origin of ventricular tachycardia. Comparison of the performance of the algorithm with visual evaluation by a human expert in this procedure revealed, in 95% of the cases, an identical or adjacent localization of the site of origin.
Anonymous State Pinning for Private Blockchains (2019)

Public blockchains such as Ethereum and Bitcoin provide transparency and accountability, and have strong non-repudiation properties, but fall far short of enterprise privacy requirements for business processes. Consequently consortiums are exploring private blockchains to keep their membership and transactions private. However, private blockchains do not provide adequate protection against potential collusion by consortium members to revert the state of the blockchain. To countenance this, the private blockchain state may be "pinned" to a tamper resistant public blockchain. Existing solutions offering pinning to the public blockchain would reveal the transaction rate of the private blockchain, and do not provide a mechanism to contest the validity of a pin. Moreover, they require that all transactions and members of the private blockchain be revealed. These challenges are hampering the wider adoption of private blockchain technology. We describe the primary author's "Anonymous State Pinning approach", which overcomes these limitations and present a security proof to demonstrate pins can be challenged without compromising these properties. We perform a gas cost analysis of the implementation to estimate the operating cost of this technology, which shows that pinning a private blockchain at the rate of one pin per hour would cost US$508 per year. A hierarchical pinning approach is proposed which would allow many private blockchains to pin to a management blockchain which would then pin to Ethereum MainNet. This approach saves money, but at the cost of increased finality times.
Optical system for a multiple-beam scanning electron microscope (2014)

A novel optical system for a multiple-beam scanning electron microscope (SEM) is proposed. In the case of multiple-beam SEM, multiple secondary-electron beams passing through the column are inherently blurred because of the large energy spread and broad angular distribution of secondary electrons. To avoid cross-talk between the multiple secondary-electron beams, the optical system is designed such that it is divided into two independent parts: one for primary-beam illumination and one for secondary-electron detection. As the key components for the secondary-electron detection, a scan-cancelling deflector, and accelerating electric field were applied. To demonstrate the proposed optical system, a prototype column with four beams was developed. This column enables four SEM images to be separately but simultaneously acquired with more than 99% of the generated secondary electrons. This result demonstrates that high-speed imaging with the proposed multiple-beam SEM is possible in the near future.
Socio-biological factors of increased morbidity risk in participants of educational process in higher education institutions related to the global epidemiological situation in 2020-2021 (2021)

One of the numerous negative consequences of the COVID-19 pandemic is the second epidemic of negative psychological effects. Population stress in modern conditions can serve as a catalyst for mental disorders of teachers and students. In the present situation, restrictive and special measures should be considered as additional harmful socio-biological factors for participants of the university educational process.
Novel OSNR Measurement Techniques for Coherent-Detection Systems (2018)

We discuss in-service OSNR measurement options independent of coherent receiver metrics. We review a spectral analysis technique for discriminating ASE when fiber nonlinearities contribute “Gaussian-like” noise and evaluate its performance in practical network scenarios.
OPTIMIZATION OF HYDROLYSIS CONDITIONS FOR THE PRODUCTION OF THREADFIN BREAM (NEMIPTERUS JAPONICUS) HYDROLYSATE BY ALCALASE (2005)

ABSTRACT The hydrolysis of Threadfin bream ( Nemipterus japonicus ) by Alcalase was optimum at 60C, pH 8.5, 120 min using an enzyme substrate (ES) ratio of 2%. With these hydrolysis conditions, 20% hydrolysis was achieved and 70% nitrogen was recovered. Sodium dodecyl sulfate‐polyacrylamide gel electrophoresis revealed more degradation with 1, 3 and 4% ES. Two percent ES produced mixtures of protein bands with a wider range of molecular weights, thus it was chosen as the optimum hydrolysis ES ratio.
Proposed Measured Display Characterization File for HDR Consumer Displays (2019)

The advent of wide color gamut and high-dynamic-range (HDR) imaging has upended long-established standards for display monitors and changed the very definition of display calibration. With the International Telecommunications Union-Radiocommunication BT.7091 standard, which in retrospect looks like a calm and pastoral monoculture, the nature of display calibration was straight-forward, i.e., adjust the behavior of the video display until its output matches the standard as closely as possible. The changes created by HDR can be seen most clearly by describing the way HDR color volume mapping works. An HDR TV’s color volume-mapping algorithm looks at the metadata that shows how the content was mastered, compares that metadata to the definition of the HDR TV’s capabilities, and applies some very intelligent mapping to make the HDR content appear as accurately as possible on the TV. A new kind of calibration process is needed to provide color accuracy while not affecting the intended behavior of the TV’s Color Volume Remapping algorithm. No standard exists for the format or mechanism of this process. This paper proposes a standard for self-description in video displays that will allow mapping algorithms to best display a variety of HDR content on a variety of display devices with differing capabilities.
Superconductivity in non-centrosymmetric sulfide Y x S 4 (2018)

We report the synthesis and characterization of the non-centrosymmetric superconductor Yx S4 (x  = 2.69, 2.75, 2.86, 2.96) using powder x-ray diffraction (XRD), magnetization, and transport measurements. It crystallized in a non-centrosymmetric Th3 P4 -type structure (space group , Z  = 4). Resistivity and DC magnetization measurements confirmed that Y2.96 S4 has type-II superconductivity with the transition temperature , lower critical field , and upper critical field . The experimental and density functional calculation results suggest that Yx S4 could be categorized as a Bardeen-Cooper-Schrieffer (BCS) superconductor with intermediate coupling.
Design of Mechanism and Preliminary Field Validation of Low-Cost Transfemoral Rotator for Use in the Developing World (2016)

Copyright © 2016 by ASME. Transfemoral (above-knee) amputees face a unique and challenging set of restrictions to movement and function. Most notably, they are unable to medially rotate their lower-leg and subsequently cross their legs. The best and most common solution to this issue today is a transfemoral rotator, which allows medial rotation of the leg distal to the knee through a lockable turntable mechanism. However, currently available transfemoral rotators can cost thousands of dollars, and few equivalent technologies exist in the developing world. This paper, supported by the results of field studies and user testing, establishes a framework for the design of a low-cost and easily manufacturable transfemoral rotator for use in the developing world. Two prototypes are presented, each with a unique internal locking mechanism and form. A preliminary field study was conducted on six transfemoral amputees in India and qualitative user and prosthetist feedback was collected. Both prototypes successfully allowed all subjects to complete tasks such as crossing legs, putting on pants, and tying shoes while maintaining functionality of walking and standing. Future iterations of the mechanism will be guided by a combination of the most positively received features of the prototypes and general feedback suggestions from the users.
Residence Time Distribution (RTD) of Particulate Foods in a Continuous Flow Pilot‐Scale Ohmic Heater (2009)

The residence time distribution (RTD) of a model particulate-fluid mixture (potato in starch solution) in the ohmic heater in a continuous sterilization process was measured using a radio frequency identification (RFID) methodology. The effect of solid concentration and the rotational speed of the agitators on the RTD were studied. The velocity of the fastest particle was 1.62 times the mean product velocity. In general, particle velocity was found to be greater than the product bulk average velocity. Mean particle residence time (MPRT) increased with an increase in the rotational speed of the agitators (P < 0.05), and no particular trend was observed between the MPRT and the solid concentration. The distribution curves E (theta) were skewed to the right suggesting slow moving zones in the system.
Books on Artifical Life and Related Topics (1993)

October 01 1993 Books on Artifical Life and Related Topics David G. Stork David G. Stork Book Review Editor, Ricoh California Research Center, 2882 Sand Hill Road, Suite 115, Menlo Park, CA, 94025-7022. stork@crc.ricoh.com Search for other works by this author on: This Site Google Scholar Author and Article Information David G. Stork Book Review Editor, Ricoh California Research Center, 2882 Sand Hill Road, Suite 115, Menlo Park, CA, 94025-7022. stork@crc.ricoh.com Online Issn: 1530-9185 Print Issn: 1064-5462 © 1994 Massachusetts Institute of Technology1994 Artificial Life (1993) 1 (1_2): 243–247. https://doi.org/10.1162/artl.1993.1.1_2.243 Cite Icon Cite Permissions Share Icon Share Twitter LinkedIn Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Search Site Citation David G. Stork; Books on Artifical Life and Related Topics. Artif Life 1993; 1 (1_2): 243–247. doi: https://doi.org/10.1162/artl.1993.1.1_2.243 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsArtificial Life Search Advanced Search This content is only available as a PDF. © 1994 Massachusetts Institute of Technology1994 Article PDF first page preview Close Modal You do not currently have access to this content.
Liquid Crystalline Properties of Polyguanidines (2004)

Modified polyguanidines were prepared, and their liquid crystalline properties were studied using optical polarizing microscopy and X-ray diffraction. Parameters examined include chirality, the uniformity of the lengths of side chains, and attached side-chain mesogens. If the side chains on the repeat units are identical, then polymer has a more ordered structure in both solution and the solid state. Uniform lengths of the side chains are also important. Poly(N,N‘-di-n-hexylguanidine), poly-I, exhibited a lyotropic smectic texture in contrast to a nematic texture of poly(N-(rac)-2-phenylethyl)-N‘-methylguanidine) (poly-(rac-II)). Optically pure poly(N-((R)-2-phenylethyl)-N‘-methylguanidine) (poly-(R-II)) formed a cholesteric texture, whereas the corresponding racemic polyguanidine, poly-(rac-II), formed a nematic texture. Additionally, poly-(R-II) displayed a mesophase at a lower critical concentration than either poly-I or poly-(rac-II), implying that poly-(R-II) is stiffer than these two other derivatives. Poly(N-6-((4‘-methoxyphenylazo)phenyl-4-oxy)hexyl-N‘-n-hexylguanidine) (poly-IV), one of combined liquid crystalline structures (liquid crystalline backbone plus liquid crystalline side chains), displayed a lyotropic nematic texture presumably due to the strong dipolar−dipolar interaction between the main chain and side chains that folds the appendages parallel to the molecular axis. Poly(N-12-((4‘-methoxybiphenyl-4-oxy)dodecyl-N‘-n-dodecylguanidine) (poly-V) and poly(N,N‘-di-n-dodecylguanidine) (poly-VI) exhibited thermotropic liquid crystalline behavior.
Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis (2022)

<b>Rationale:</b> Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and often fatal disorder. Two U.S. Food and Drug Administration-approved antifibrotic drugs, nintedanib and pirfenidone, slow the rate of decline in lung function, but responses are variable and side effects are common. <b>Objectives:</b> Using an <i>in silico</i> data-driven approach, we identified a robust connection between the transcriptomic perturbations in IPF disease and those induced by saracatinib, a selective Src kinase inhibitor originally developed for oncological indications. Based on these observations, we hypothesized that saracatinib would be effective at attenuating pulmonary fibrosis. <b>Methods:</b> We investigated the antifibrotic efficacy of saracatinib relative to nintedanib and pirfenidone in three preclinical models: <i>1</i>) <i>in vitro</i> in normal human lung fibroblasts; <i>2</i>) <i>in vivo</i> in bleomycin and recombinant Ad-TGF-β (adenovirus transforming growth factor-β) murine models of pulmonary fibrosis; and <i>3</i>) <i>ex vivo</i> in mice and human precision-cut lung slices from these two murine models as well as patients with IPF and healthy donors. <b>Measurements and Main Results:</b> In each model, the effectiveness of saracatinib in blocking fibrogenic responses was equal or superior to nintedanib and pirfenidone. Transcriptomic analyses of TGF-β-stimulated normal human lung fibroblasts identified specific gene sets associated with fibrosis, including epithelial-mesenchymal transition, TGF-β, and WNT signaling that was uniquely altered by saracatinib. Transcriptomic analysis of whole-lung extracts from the two animal models of pulmonary fibrosis revealed that saracatinib reverted many fibrogenic pathways, including epithelial-mesenchymal transition, immune responses, and extracellular matrix organization. Amelioration of fibrosis and inflammatory cascades in human precision-cut lung slices confirmed the potential therapeutic efficacy of saracatinib in human lung fibrosis. <b>Conclusions:</b> These studies identify novel Src-dependent fibrogenic pathways and support the study of the therapeutic effectiveness of saracatinib in IPF treatment.
SAT-543 Human Hair Aldosterone Measurements for Evaluation of Primary Aldosteronism (2020)

Abstract Background: Primary Aldosteronism (PA) is the most common cause of endocrine hypertension in US. Diagnostic techniques such as a 24 hour urine collection or saline suppression test (SST) can be laborious for both patients and staff. Our group previously showed that human hair cortisol measurements correlated with urine and serum cortisol levels in patients with endogenous cortisol excess. In this study, we explored whether human hair aldosterone correlated with other measures of aldosterone production. Methods: 41 adult subjects were evaluated at the NIH Clinical Center for adrenal disorders. A pencil-width of hair near the occiput was removed, and the 1cm segment closest to the scalp was analyzed by enzyme immunoassay for aldosterone, reported as pg aldosterone/mg dry hair. Not all subjects underwent complete workup for PA. Data were transformed as necessary to maintain assumptions of normality. Student’s t-test and Pearson correlations were used for statistical analysis. Results: Of the evaluated subjects, 18 were diagnosed with PA, 22 subjects did not have PA, and 1 subject was indeterminate. The mean hair weight was 33.0±13.7mg. For hair samples weighing greater than 10mg, hair weight was not correlated with hair aldosterone concentration (p=0.40). There was no difference in measured hair aldosterone between the subjects with and without PA (2.01±1.09 vs. 2.52±2.45 pg/mg; p=0.82). Among all subjects, hair aldosterone did not correlate with serum aldosterone (p=0.92), aldosterone-to-renin ratio (ARR; p=0.94), 24 hour urine aldosterone (Ualdo; p=0.85), or the serum aldosterone at the 4 hour time point of a SST (4hrAldo; p=0.98). Serum aldosterone, ARR, Ualdo, and 4hrAldo all correlated highly amongst each other (all p’s&amp;lt;0.001). Conclusions: Hair aldosterone levels do not correlate with other markers of PA. Further work is needed to understand whether optimization of study conditions could improve the usefulness of hair aldosterone measurements in the evaluation of PA.
Correction to Observation of Multiple Vibrational Modes in Ultrahigh Vacuum Tip-Enhanced Raman Spectroscopy Combined with Molecular-Resolution Scanning Tunneling Microscopy (2012)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Observation of Multiple Vibrational Modes in Ultrahigh Vacuum Tip-Enhanced Raman Spectroscopy Combined with Molecular-Resolution Scanning Tunneling MicroscopyN. Jiang, E. T. Foley, J. M. Klingsporn, M. D. Sonntag, N. A. Valley, J. A. Dieringer, T. Seideman, G. C. Schatz, M. C. Hersam*, and R. P. Van Duyne*Cite this: Nano Lett. 2012, 12, 12, 6506Publication Date (Web):November 9, 2012Publication History Published online9 November 2012Published inissue 12 December 2012https://pubs.acs.org/doi/10.1021/nl304082mhttps://doi.org/10.1021/nl304082mcorrectionACS PublicationsCopyright © 2012 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views816Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (102 KB) Get e-Alertsclose Get e-Alerts
C1-inhibitor attenuates neurobehavioral deficits following controlled cortical impact brain injury in mice (2007)

Hydrogen sulfide is produced endogenously by a variety of enzymes involved in cysteine metabolism. Clinical data indicate that endogenous levels of hydrogen sulfide are diminished in various forms of cardiovascular diseases. The aim of the current study was to investigate the effects of hydrogen sulfide supplementation on cardiac function during reperfusion in a clinically relevant experimental model of cardiopulmonary bypass. Twelve anesthetized dogs underwent hypothermic cardiopulmonary bypass. After 60 minutes of hypothermic cardiac arrest, reperfusion was started after application of either saline vehicle (control, n = 6), or the sodium sulfide infusion (1 mg/kg/hour, n = 6). Biventricular hemodynamic variables were measured by combined pressure-volume-conductance catheters. Coronary and pulmonary blood flow, vasodilator responses to acetylcholine and sodiumnitroprusside and pulmonary function were also determined. Administration of sodium sulfide led to a significantly better recovery of left and right ventricular systolic function (P < 0.05) after 60 minutes of reperfusion. Coronary blood flow was also significantly higher in the sodium sulfide-treated group (P < 0.05). Sodium sulfide treatment improved coronary blood flow, and preserved the acetylcholine-induced increases in coronary and pulmonary blood (P < 0.05). Myocardial ATP levels were markedly improved in the sulfide-treated group. Thus, supplementation of sulfide improves the recovery of myocardial and endothelial function and energetic status after hypothermic cardiac arrest during cardiopulmonary bypass. These beneficial effects occurred without any detectable adverse hemodynamic or cardiovascular effects of sulfide at the dose used in the current study.
Pilot study of the diagnostic utility of 89Zr‐df‐IAB2M and 68Ga‐PSMA‐11 PET imaging and multiparametric MRI in localized prostate cancer (2022)

In this pilot study, the performance of <sup>89</sup> Zr-df-IAB2M was superior to mpMRI and similar to <sup>68</sup> Ga-PSMA-11 PET/CT. The higher detection rate of PSMA-PET supports its use as a diagnostic tool with consequent management change implications in men with localized PCa.
Effect of lower extremity functional electrical stimulation pulsed isometric contractions on arm cycling peak oxygen uptake in spinal cord injured individuals (2013)

VO2peak increased when ACE was combined with FES iso hybrid or FES hybrid cycling in persons with spinal cord injury above the T6 level. Portable FES may serve as a less resource-demanding alternative to stationary FES cycling, and may have important implications for exercise prescription for spinal cord injury.
Human water contacts patterns in Schistosoma mansoni epidemic foci in northern Senegal change according to age, sex and place of residence, but are not related to intensity of infection (2003)

In an epidemic focus in northern Senegal, adults had lower intensities of infection than adolescents, a phenomenon that could not be attributed to immunity acquired over the previous 10-15 years of exposure to the parasite because all age groups had had the same number of years' experience of the worm. This article considers whether this pattern could have been because of higher levels of exposure to the parasite in younger age groups. Personal contact with infected water was recorded using a questionnaire in Schistosoma mansoni foci not more than 3 years old and in another, 10-year-old focus. Many aspects of contact (e.g. frequency, duration or time of day of contact) may contribute to the number of encounters with infective cercariae (true exposure), so various assumptions regarding the relationship between water contact and true exposure were tested resulting in a range of exposure indices. People reported a mean of 4.4 separate contacts, and spent a median of 57 min per day in water. Patterns of water contact differed depending on the exposure index used, e.g. considering duration, males spent a longer time in water than females (P < 0.001). But using frequency, females had more contacts with water than males in most villages (P < 0.001). Generally, exposure levels dropped as people become aged (P < 0.001) and residents of the older focus were more exposed than residents of other foci (P < 0.002). Intensity of (re)infection was not related to exposure either alone or in models incorporating age, sex and/or village irrespective of the index used. There is therefore evidence that age, sex and place of residence determine exposure but none to suggest that exposure had an influence on the relationship between these factors and intensity of infection. We propose therefore that in this population other factors have principal importance in determining intensity of infection.