gebhart/patrepeval huggingface dataset:
Antitumor Activity of VB-111, a Novel Antiangiogenic Virotherapeutic, in Thyroid Cancer Xenograft Mouse Models (2011)

VB-111 is an engineered antiangiogenic adenovirus that expresses Fas-c in angiogenic blood vessels and has previously been shown to have significant antitumor activity in vitro and in vivo in Lewis lung carcinoma, melanoma, and glioblastoma models. To evaluate the efficacy of VB-111 in thyroid cancer, we conducted in vivo xenograft nude mouse studies using multiple thyroid cancer-derived cell lines models. VB-111 treatment resulted in 26.6% (P = 0.0596), 34.4% (P = 0.0046), and 37.6% (P = 0.0249) inhibition of tumor growth in follicular, papillary and anaplastic thyroid cancer models, respectively. No toxicity was observed in any model. All tumor types showed a consistent and significant reduction of CD-31 staining (P < 0.05), reflecting a reduction of angiogenic activity in the tumors, consistent with the intended targeting of the virus. A phase 2 clinical trial of VB-111 in patients with advanced differentiated thyroid cancer is ongoing.
Developing an integrated genomic selection approach beyond biomass for varietal protection and nutritive traits in perennial ryegrass (Lolium perenne L.) (2023)

Breeding target traits can be broadened to include nutritive value and plant breeder's rights traits in perennial ryegrass by using in-field regression-based spectroscopy phenotyping and genomic selection. Perennial ryegrass breeding has focused on biomass yield, but expansion into a broader set of traits is needed to benefit livestock industries whilst also providing support for intellectual property protection of cultivars. Numerous breeding objectives can be targeted simultaneously with the development of sensor-based phenomics and genomic selection (GS). Of particular interest are nutritive value (NV), which has been difficult and expensive to measure using traditional phenotyping methods, resulting in limited genetic improvement to date, and traits required to obtain varietal protection, known as plant breeder's rights (PBR) traits. In order to assess phenotyping requirements for NV improvement and potential for genetic improvement, in-field reflectance-based spectroscopy was assessed and GS evaluated in a single population for three key NV traits, captured across four timepoints. Using three prediction approaches, the possibility of targeting PBR traits using GS was evaluated for five traits recorded across three years of a breeding program. Prediction accuracy was generally low to moderate for NV traits and moderate to high for PBR traits, with heritability highly correlated with GS accuracy. NV did not show significant or consistent correlation between timepoints highlighting the need to incorporate seasonal NV into selection indexes and the value of being able to regularly monitor NV across seasons. This study has demonstrated the ability to implement GS for both NV and PBR traits in perennial ryegrass, facilitating the expansion of ryegrass breeding targets to agronomically relevant traits while ensuring necessary varietal protection is achieved.
<title>Haptic-feedback-based robotic teleparamedics</title> (2002)

In this paper a novel teleparamedic robot concept, based on high practicality and economy has been presented. This new UGV (Unmanned Ground Vehicle) has haptic feedback-based driving and teleparamedic robotic operation, based on true 3-D visualization. The robotic operations include: soldier evacuation and two basic FAM (First Aid Measure) modes.
Hydrogen Generation Catalyzed by Fluorinated Diglyoxime–Iron Complexes at Low Overpotentials (2012)

Fe(II) complexes containing the fluorinated ligand 1,2-bis(perfluorophenyl)ethane-1,2-dionedioxime (dAr(F)gH(2); H = dissociable proton) exhibit relatively positive Fe(II/I) reduction potentials. The air-stable difluoroborated species [(dAr(F)gBF(2))(2)Fe(py)(2)] (2) electrocatalyzes H(2) generation at -0.9 V vs SCE with i(cat)/i(p) ≈ 4, corresponding to a turnover frequency (TOF) of ∼20 s(-1) [Faradaic yield (FY) = 82 ± 13%]. The corresponding monofluoroborated, proton-bridged complex [(dAr(F)g(2)H-BF(2))Fe(py)(2)] (3) exhibits an improved TOF of ∼200 s(-1) (i(cat)/i(p) ≈ 8; FY = 68 ± 14%) at -0.8 V with an overpotential of 300 mV. Simulations of the electrocatalytic cyclic voltammograms of 2 suggest rate-limiting protonation of an Fe("0") intermediate (k(RLS) ≈ 200 M(-1) s(-1)) that undergoes hydride protonation to form H(2). Complex 3 likely reacts via protonation of an Fe(I) intermediate that subsequently forms H(2) via a bimetallic mechanism (k(RLS) ≈ 2000 M(-1) s(-1)). 3 catalyzes production at relatively positive potentials compared with other iron complexes.
Efficacy of Biological Therapies in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis (2011)

Biological therapies were superior to placebo in inducing remission of active CD and UC, and in preventing relapse of quiescent CD.
Cover Picture: Heterobimetallic Calix[4]arene Complexes: Interconversion of Dimeric (Ca, Sr or Ba)/TiIV Complexes with a Monomeric K/TiIV Complex (Eur. J. Inorg. Chem. 23/2003) (2003)

Abstract The cover picture shows the structures of two new types of calix[4]arene complexes obtained by deprotonating the calixarene with an alkaline earth metal, or potassium metal, followed by reaction with selected titanium( IV ) compounds. The alkaline earth metals form dimeric alkaline earth‐titanium( IV ) complexes, containing at the core a rhombus of alternating alkaline earth metal and μ 3 ‐oxo centres. Each oxo centre of the rhombic core is the apical ligand of a square‐pyramidal titanium( IV ) centre, whose basal plane donors are the four phenolate oxygen atoms from a calix[4]arene arrayed in the symmetrical cone conformation. Terminal methanol ligands surround the alkaline earth centres, and simultaneously hydrogen‐bond to the adjacent phenolate oxygen atoms. Potassium reacts with calix[4]arene and the titanium( IV ) source to give a monomeric mixed potassium‐titanium complex. The potassium cation binds within the κ‐basic calix[4]arene cavity, whilst the titanium centre is octahedrally complexed in the exo position by four phenolate and one acetylacetonate ligands. A solution pathway exists for the interconversion between the potassium‐titanium calix[4]arene monomer and the alkaline earth‐titanium dimers, where the product is dictated by the choice of solvent. Details are discussed in the article by R. N. Lamb et al. on p. 4153 ff.
Phenomenon of End of Life in a Fluorescent Lamp and By-Investigation of Alkali Metal Adsorption System (2003)

The mechanism that causes the end of lamp life (EOLL) phenomenon in a fluorescent lamp should be clarified to achieve an effective measure for that. The EOLL phenomenon, including the tungsten sputtering from an electrode, is investigated. We observed the electron emission from a lead in the vicinity of the stem glass. The electron emission causes the intermittent pulse discharge that heats up the stem glass. The concentration of lamp current directly into one of leads is another factor to heat up a small glass portion around the lead. The comparison of the stem glass resistance and the glow discharge impedance between leads after the filament disconnection indicates whether or not the stem glass will begin to soften. It was shown that the heating of a small glass portion around the lead was a dominant factor that resulted in the final stage of EOLL, that is, a substantial overheating of a lamp end portion. The way of operation for testing the life-ended fluorescent lamps is expected to contribute to the further understanding of the alkali metal adsorbate on metal surface.
ChemInform Abstract: Fusicoccin Ring System by [4 + 4] Cycloaddition. Control of Diastereoselectivity Through Hydrogen Bonding. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Utility-Based Cache Partitioning (2006)

This paper investigates the problem of partitioning a shared cache between multiple concurrently executing applications. The commonly used LRU policy implicitly partitions a shared cache on a demand basis, giving more cache resources to the application that has a high demand and fewer cache resources to the application that has a low demand. However, a higher demand for cache resources does not always correlate with a higher performance from additional cache resources. It is beneficial for performance to invest cache resources in the application that benefits more from the cache resources rather than in the application that has more demand for the cache resources. This paper proposes utility-based cache partitioning (UCP), a low-overhead, runtime mechanism that partitions a shared cache between multiple applications depending on the reduction in cache misses that each application is likely to obtain for a given amount of cache resources. The proposed mechanism monitors each application at runtime using a novel, cost-effective, hardware circuit that requires less than 2kB of storage. The information collected by the monitoring circuits is used by a partitioning algorithm to decide the amount of cache resources allocated to each application. Our evaluation, with 20 multiprogrammed workloads, shows that UCP improves performance of a dualcore system by up to 23 % and on average 11 % over LRU-based cache partitioning. 1
Mesenchymal stem cell-mediated delivery of therapeutic adenoviral vectors to prostate cancer (2019)

The results show that this approach, if optimized, could circumvent the obstacles to efficient gene delivery encountered with current gene delivery approaches and provide an effective, nontoxic therapeutic alternative for metastatic disease.
A theoretical study of the energy of hypofluorous acid, HOF (1989)

An ab initio molecular orbital study of the dissociation energy of HOF based on the newly developed G1 method is presented. The results indicate that the value of ΔH○f0 of gaseous HOF derived by Berkowitz, Appelman, and Chupka should be reexamined and that the best experimentally derived value of ΔH○f0 of HOF is −19.9 kcal/mol, corresponding to a dissociation energy D0(HO–F) of 47.5 kcal/mol.
Eliminating a polysilicon hole defect created during oxide removal (2011)

Gate Oxide failure analysis during technology qualification led to discovery of the polysilicon hole defects in large (>;200K μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) PMOS capacitors. In-line KLA inspections confirmed that polysilicon holes were formed during the salicide block process module. It is hypothesized that a three way interaction between the P+ source/drain implanted boron, heat added during salicide block mask deposition, and NH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> + in the BOE causes the polysilicon hole. By replacing the BOE (Buffered Oxide Etchant) with a 100:1 HF solution, the creation of polysilicon holes was eliminated as confirmed by KLA and VBD testing.
Nanofibrillation of Dry Chitin Powder by Star Burst System (2012)

Chitin nanofibers were prepared from dry chitin powder by nanofibrillation using a Star Burst instrument employing a high‐pressure water jet system. FE‐SEM micrographs showed that the nanofibers became thinner as the number of Star Burst passes increased. Fibrillation in an acidic condition made the chitin fibers thinner than those in a neutral condition. The transmittance spectra of chitin nanofiber/acrylic resin composites led us to the same conclusion. In addition, chitin nanofibers prepared by treatment consisting of five Star Burst passes in the neutral condition were thinner than the previously reported nanofibers. X‐ray diffraction profiles showed that the Star Burst system did not damage the chitin nanofibers and did not reduce their crystallinity.
Flattening of a patterned compliant solid by surface stress (2014)

We measured the shape change of periodic ridge surface profiles in gelatin organogels resulting from deformation driven by their solid-vapor surface stress. A gelatin organogel was molded onto poly-dimethylsiloxane (PDMS) masters having ridge heights of 1.7 and 2.7 μm and several periodicities. Gel replicas were found to have a shape deformed significantly compared to their PDMS master. Systematically larger deformations in gels were measured for lower elastic moduli. Measuring the elastic modulus independently, we estimate a surface stress of 107 ± 7 mN m(-1) for the organogels in solvent composed of 70 wt% glycerol and 30 wt% water. Shape changes are in agreement with a small strain linear elastic theory. We also measured the deformation of deeper ridges (with height 13 μm), and analysed the resulting large surface strains using finite element analysis.
Stress relaxation in semipolar and nonpolar III-nitride heterostructures by formation of misfit dislocations of various origin (2019)

We present an analytical model describing misfit stresses relaxation in semipolar III-nitride heterostructures caused by misfit dislocations (MDs) originating from basal or prismatic slip and by sessile MDs. We analyze the critical thickness hc for the formation of MDs depending on crystal lattice mismatch and orientation of the semipolar growth plane. We explore transversely isotropic elasticity solutions to describe the relaxation processes in III-nitride semipolar heterostructures and compare the results for hc with those calculated within the isotropic elasticity approach. We find that the value of angle ϑ between the polar с-axis, and the direction of heterostructure growth has an impact on the realization of the stress relaxation mechanism by the generation of MDs originating either from basal or prismatic slip. A comparison of theoretical calculations with experimental data on the observation of MDs in the III-nitride heterostructures is provided.
Acquiring short range 4D light transport with synchronized projector camera system (2018)

Light interacts with a scene in various ways. For scene understanding, a light transport is useful because it describes a relationship between the incident light ray and the result of the interaction. Our goal is to acquire the 4D light transport between the projector and the camera, focusing on direct and short-range transport that include the effect of the diffuse reflections, subsurface scattering, and inter-reflections. The acquisition of the light transport is challenging since the acquisition of the full 4D light transport requires a large number of measurement. We propose an efficient method to acquire short range light transport, which is dominant in the general scene, using synchronized projector-camera system. We show the transport profile of various materials, including uniform or heterogeneous subsurface scattering.
Different Outcome for Angioimmunoblastic T-Cell Lymphoma (AIL) and Peripheral T-Cell Lymphoma Unspecified (PTCL-U) Following Upfront Autologous Stem Cell Transplantation. (2006)

Abstract Introduction: Peripheral T-cell lymphomas (PTCL) are rare diseases and optimal treatment strategies still remain to be defined. With the exception of the ALK-positive anaplastic large cell lymphoma (ALCL) that shows a favourable outcome following conventional chemotherapy, PTCL are known for their poorer prognosis compared to aggressive B-cell lymphomas. However, the impact of the different PTCL-subtypes on treatment outcome has not been clearly demonstrated in prospective studies. PTCL unspecified (PTCL-U) and angioimmunoblastic T-cell lymphoma (AIL) represent the most common subtypes of PTCL in Western countries, accounting for approximately 70% of PTCL. We therefore analysed the data of our study on myeloablative radiochemotherapy followed by autologous stem cell transplantation (ASCT) in primary diagnosed PTCL with regard to the main histologic subtypes. Material and Methods: From 06/00 to 06/06 92 patients with confirmed diagnosis of PTCL entered the study. Primary cutaneous PTCL and ALK+ ALCL were excluded from the trial. Main subtypes were PTCL-U (n= 37) and AIL (n= 28) accounting for 65 of the 92 patients (71%). 0f these patients 53 (PTCL, n= 31; AIL, n= 22) were evaluable for the analysis (82%). Results: Median age was 50 years in the PTCL-U and 47.5 years in the AIL group, respectively. The International Prognostic Index (IPI) did not differ in both groups. In the PTCL-U and the AIL group a low/intermediate-low risk was found in 35% and 36%, respectively and a high/intermediate-high risk in 65% and 64%, respectively. There were slightly more patients in stage IV in the AIL group compared to the PTCL-U group (64% versus 53%). In addition, more patients in the AIL group complained of B-symptoms and had bone marrow involvement compared to the PTCL-U group (86% versus 66% and 48% versus 39%, respectively). However, in an intent-to treat analysis only 58% in the PTCL-U group compared to 82% in the AIL group underwent ASCT mainly due to a higher rate of patients with progressive disease in the PTCL-U group. The median overall survival (OS) was 11 months in the PTCL-NOS and 20 months in the AIL group. Regarding only patients undergoing ASCT, the median OS was 13.5 months in the PTCL-U and 25.5 months in the AIL group. Conclusion: Our analysis suggests that patients with AIL, although showing a slightly more unfavourable risk profile at diagnosis, benefit more from upfront autotransplantation than patients with PTCL-U in our study.
A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA (2017)

We describe a simple, robust and high throughput single molecule flow-stretching assay for studying 1D diffusion of molecules along DNA. In this assay, glass coverslips are functionalized in a one-step reaction with silane-PEG-biotin. Flow cells are constructed by sandwiching an adhesive tape with pre-cut channels between a functionalized coverslip and a PDMS slab containing inlet and outlet holes. Multiple channels are integrated into one flow cell and the flow of reagents into each channel can be fully automated, which significantly increases the assay throughput and reduces hands-on time per assay. Inside each channel, biotin-λ-DNAs are immobilized on the surface and a laminar flow is applied to flow-stretch the DNAs. The DNA molecules are stretched to >80% of their contour length and serve as spatially extended templates for studying the binding and transport activity of fluorescently labeled molecules. The trajectories of single molecules are tracked by time-lapse Total Internal Reflection Fluorescence (TIRF) imaging. Raw images are analyzed using streamlined custom single particle tracking software to automatically identify trajectories of single molecules diffusing along DNA and estimate their 1D diffusion constants.
Analysis and metaanalysis of two polymorphisms within the tyrosine hydroxylase gene in bipolar and unipolar affective disorders (1999)

Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of dopamine and noradrenaline. While positive associations between TH and bipolar affective disorder have been found in several studies, many studies have failed to reproduce these results. In order to clarify this situation, association studies of bipolar and unipolar affective disorder groups and metaanalyses of published data on the TH tetranucleotide repeat polymorphism were done. The association studies used the TH tetranucleotide repeat polymorphism in intron 1 and a PstI polymorphism at the 3' end of the gene. The study comprised 124 unrelated bipolar patients, 126 unipolar patients, and 242 controls. There was no significant association of either bipolar or unipolar affective disorder with the TH tetranucleotide repeat polymorphism. However, a weak association (chi2 = 3.946, 1 df, P = 0.047; odds ratio, allele 2 vs. allele 1 = 0.71 (95% CI, 0.51-0.996)) was observed in the unipolar sample with the TH-PstI polymorphism. Three metaanalyses of published data on the TH tetranucleotide repeat polymorphism in major affective disorder were performed: bipolar I + II vs. control using 583 cases and 745 controls; unipolar vs. control using 204 cases and 359 controls; and bipolar + unipolar vs. control using 846 cases and 823 controls. In each analysis there was no association of the TH tetranucleotide repeat polymorphism and affective disorder. These results do not support the tyrosine hydroxylase gene having a major role in the etiology of bipolar affective disorder. However, our data suggest that this locus should be examined in larger samples of unipolar affective disorder.
Tris(2-pyridylmethyl)triazacyclododecane complexes of FeIIand CuII (1999)

The title complexes, [1,5,9-tris(2-pyridylmethyl)-1,5,9-triazacyclododecane-κ 3 N]iron(II) tetrachloroferrate, [Fe(C 27 H 36 N 6 )][FeCl 4 ], and [1,5,9-tris(2-pyridylmethyl)-1,5,9-triazacyclododecane-κ 3 N]copper(III)bis(hexafluorophosphate) acetonitrile hemisolvate, [Cu(C 27 H 36 N 6 )](PF 6 ) 2 .0.5CH 3 CN, differ significantly in their conformations. The iron complex is near-octahedral, with Fe-N distances of 2.257 (5) (ring) and 2.226 (5) A (pyridine), and fused chelate rings predominately in the boat form. The copper complex is tetragonally distorted, with four shorter and two longer Cu-N bonds [2.049 (6)-2.199 (7) and 2.280 (6)-2.473 (7) A, respectively]; its chelate rings are disordered in boat, chair and skew forms.
Optically Stimulated Deep‐Level Impedance Spectroscopy: Application to an n‐GaAs Schottky Diode (1996)

Optically stimulated deep‐level impedance spectroscopy is shown to be sensitive to transitions between deep‐level states in an n‐GaAs Schottky diode. The technique is based on interpretation of both the real and imaginary components of the impedance response over a continuous range of electrical frequencies under sub‐bandgap illumination. The results obtained are compared to those by deep‐level transient spectroscopy and thermally stimulated deep‐level impedance spectroscopy. Optical energies associated with onset of electronic transitions are easily identified at low electrical frequencies and from regression to the resulting spectra of a model that accounts for the influence of deep‐level states.
Finite element reconstruction of a vehicle-to-pedestrian impact (2020)

Finite element reconstructions of real-world pedestrian impacts are useful for analyzing pedestrian kinematics and provide an effective tool for improving pedestrian impact injury analyses.