gebhart/patrepeval huggingface dataset:
Power conversion and luminous efficiency performance of nanophosphor quantum dots on color-conversion LEDs for high-quality general lighting (2012)

For high-quality general lighting, a white light source is required to exhibit good photometric and colorimetric performance along with a high level of electrical efficiency. For example, a warm white shade is desirable for indoors, corresponding to correlated color temperatures &ge;4000 K, together with color rendering indices &ge;90. Additionally, the luminous efficacy of optical radiation (LER) should be high, preferably &ge;380 lm/W<sub>opt</sub>. Conventional white LEDs cannot currently satisfy these requirements simultaneously. On the other hand, color-conversion white LEDs (WLEDs) integrated with quantum dots (QDs) can simultaneously reach such high levels of photometric and colorimetric performance. However, their electrical efficiency performance and limits have been unknown. To understand their potential of luminous efficiency (lm/Welect), we modeled and studied different QD-WLED architectures based on layered QD films and QD blends, all integrated on blue LED chips. The architecture of red, yellow and green emitting QD films (in this order from the chip outwards) is demonstrated to outperform the rest. In this case, for photometrically efficient spectra, the maximum achievable LE is predicted to be 327 lm/W<sub>elect</sub>. Using a state-of-the-art blue LED reported with a power conversion efficiency (PCE) of 81.3%, the overall WLED PCE is shown to be 69%. To achieve LEs of 100, 150 and 200 lm/Welect, the required minimum quantum efficiencies of the color-converting QDs are found to be 39, 58 and 79%, respectively.
Ex vivo adenovirus mediated gene transfection of human conjunctival epithelium (2001)

These results confirm previous successful adenoviral vector mediated gene transfer to HCs and further show that expression can be maintained. Furthermore the data show HCs can secrete biologically active vIL-10 that could be developed as a strategy to suppress immune mediated disorders. The successful co-transduction of HCs as described for other tissues, opens avenues to develop a multiple target gene therapy locally.
Figure S3 from Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain Tumors (2023)

&lt;p&gt;A, quantification of genomic damage (γH2AX foci) in TIFs-negative (non-TIF) and TIFs-positive (TIF) HFF+hTERT cells treated or untreated (DMSO) with 3 µM of 6-thio-dG for 3 days. Error bars represent the standard deviation from three independent experiments. P-value is indicated, ***&lt;0.001. B, quantification of γH2AX foci in non-TIF and TIFs-positive HFF+hTERT cells treated with DMSO, imetelstat (IMT; 2 µM), 6-thio-dG (3 µM for 3 days), or in combination as described in figure S2A.&lt;/p&gt;
Confirmatory factor analysis and measurement invariance of the English, Mandarin, and Malay versions of the SF-12v2 within a representative sample of the multi-ethnic Singapore population (2021)

The present study identified a two-factor (physical and mental health) structure within the general population and amongst the three different languages and demonstrated the measurement invariance of SF-12v2 across different subgroups. Findings indicate that algorithm-derived PCS and MCS should be interpreted with caution as they may result in inaccurate conclusions regarding the relationships between HRQoL and its correlates. Future studies using the SF-12v2 within the general population of Singapore should consider utilizing the factor structure put forth in the present study to obtain more appropriate estimates of HRQoL.
Effect of Balsam Woolly Adelgid Infestation on the Structure of Wood and Bark (2005)

The effect of BWA infestation on the chemical composition of Fraser fir wood and bark was elucidated. Components of wood and bark have been characterized by wet chemistry methods, correlation 2D NMR techniques (HMQC, HMBC, TOCSY) and quantitative {13}C and {1}H NMR. In response to infestation Fraser fir produces reddish wood (Rotholz) with a high density and low conductivity that is responsible for the tree death. The Rotholz wood was found to have 13% higher lignin content and more than 5 times the amount of galactans than that of the unifested wood. Rotholz lignin possesses higher amounts of p-hydroxyphenyl units and aliphatic OH groups and a lower amount of Alkyl-O-Alkyl linkages and dibenzodioxosin moieties. Chemical analysis of inner and outer bark samples from infested A. fraseri, unifested A. fraseri and resistant A. veitchii showed a tendency toward lower amounts of lipophilic extractives and higher amounts of low molecular mass phenols and polyphenols in bark of infested trees as compared to the bark of uninfested trees. An NMR approach elaborated for analysis of an ethanol-soluble fraction allows characterization of the phenolic compounds without tedious chromatographic separation. These fractions consist predominantly of flavanoids with small amounts of phenylpropanoids and lignans. The bark polyphenolics of the infested trees contain much higher amounts of p-hydroxyphenyl (H) moieties and lower amount of guaiacyl (G) aromatic moieties than that of uninfested Fraser fir. The amount of H-moieties in bark polyphenolics of the resistant Veitch fir is also high, but this does not result in decrease in the G-unit content in contrast to infested Fraser fir.
Improving Glaucoma Detection Using Spatially Correspondent Clusters of Damage and by Combining Standard Automated Perimetry and Optical Coherence Tomography (2014)

A combined structure-function metric improved the detection of glaucomatous eyes. Overall, the primary sources of value-added for glaucoma detection stem from the continuous cluster search (the pcc), the mRGCPL data, and the combination of structure and function.
Coronary artery bypass grafting vs. percutaneous coronary intervention for patients with three-vessel disease: final five-year follow-up of the SYNTAX trial (2014)

NCT00114972.
Subpicosecond optical hole burning in CdSe microcrystallites (1990)

Restriction of excitons in semiconductor structures of reduced dimensionality results in increased oscillator strength in the excitonic absorption, which can be exploited in the design of nonlinear optical devices.1 We report transient bleaching studies of CdSe quantum dots whose size (35 A) is small compared to the exciton radius in bulk CdSe. The clusters are grown by a new synthetic method,2 which results in high quantum yield of band edge luminescence, low saturation intensities (~100 μj/cm2), and long bleaching recovery times (nanoseconds). Most of our measurements are done at 25 K in dilute glasses containing the clusters.
Establishment of an Assay System for the Detection of Translated Materials of T Cell‐Replacing Factor mRNA in Xenopus Oocytes (1986)

Abstract We established an assay system for detecting T cell‐replacing factor (TRF) activity of translated materials in Xenopus oocytes of poly (A)‐positive mRNA extracted from a T cell hybrid cell line, B151K12 (B151) which constitutively produces TRF. Since it was difficult to detect TRF activity of the translated products of B151‐mRNA, partly because of low TRF activities, we developed the following two systems. First, RNA was prepared from B151 cells stimulated with phorbol myristate acetate and calcium ionophore A23187 because such stimulations augmented TRF production by approximately three to five‐fold. Second, interleukin 2 (IL‐2, 125 U/ml) was added to the culture of BCL 1 cells to detect a small amount of TRF‐active materials since IL‐2 synergizes with a suboptimal dose of TRF to induce IgM secretion in TRF‐responding BCL 1 cells (chronic B cell leukemic cells). Here we describe TRF activity of translation products of B151‐mRNA in Xenopus oocytes. B151‐TRF mRNA was detected in the fractions sedimented between 15 and 18S by analysis using sucrose density gradient centrifugation.
Triple combination therapy of favipiravir plus two monoclonal antibodies eradicates influenza virus from nude mice (2020)

Prolonged treatment of immunocompromised influenza patients with viral neuraminidase (NA) inhibitors is required, because the immune system of such patients fails to eradicate the viruses. Here, we attempted to eradicate influenza virus from the respiratory organs of nude mice, which is a model of immunocompromised hosts, by using combination therapy of the viral polymerase inhibitor favipiravir and monoclonal antibodies (mAbs) against the receptor-binding site (RBS) and stem of viral hemagglutinin (HA). Although monotherapy or combination therapy of two antivirals (two mAbs or favipiravir plus a mAb) suppressed virus replication, they failed to eradicate viruses from nude mice. In contrast, the triple combination therapy of favipiravir plus anti-Stem and anti-RBS mAbs completely stopped virus replication in nude mice, resulting in virus clearance. Triple combination approaches should be considered for the treatment of human immunocompromised patients with severe influenza.
Rome Laboratory Integrated Diagnostic (ID) Workbench. (1996)

Abstract : Integrated Diagnostics help reduce costs and improve mobility and mission effectiveness. Integrated diagnostics start when a product is first designed and developed, and conclude only when the product is no longer in use. The integrated diagnostic workbench automates how a test program set (TPS) is developed. A TPS is used on an automated test system (ATS) to verify and diagnose circuits, modules, and systems against a set of expected responses induced by a forced stimulus. This set of expected responses and a forced stimulus is referred to as a vector set. The purpose of such an integration effort is to facilitate more efficient and cost effective development and documentation of test programs for electronic systems and equipment. The goal of these efforts is to reduce both the initial and rehost generation time and cost of TPSs, and to allow greater flexibility when workload is determined. The Rome Laboratory Integrated Diagnostic (ID) Workbench is a set of integrated diagnostic tools executed from a common graphical user interface (GUI). The tools that compose the workbench are broken into two main categories, test automation and vector translation.
Germanium Antimonide Phase-Change Nanowires for Memory Applications (2008)

GeSb nanowires (NWs) have been grown using a vapor-liquid-solid approach for the fabrication of electrically operated phase-change random access memory device. The NWs are 40-100 nm in diameter and have approximately 90% Sb for fast crystallization. Memory devices show an on/off resistance ratio of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> , reset programming current of 0.7 mA, and set programming current of 60 nA.
Piezoelectric properties and micro structures of lead titanate thin films for GHz-band bulk acoustic wave filters (1998)

Abstract The bulk acoustic wave filters at GHz bands were fabricated using lead titanate, PbTiO3 (PT) piezoelectric films which were deposited by RF magnetron sputtering and were oriented along <111> crystal direction. To improve the quality of PT films, the bottom electrodes which had the Ti-diffusion suppressible layers were designed and prepared. X-ray diffraction intensity of the PT(111) became 5 times larger and degree of crystal orientation became 2 times stronger in comparison with those of the former PT films. The filters using the improved PT films had the insertion loss of -14dB. The PT film had effective electromechanical coupling coefficient (k) of 31% and electrical Q of 50. This k value was superior to those of well-known ZnO and AlN piezoelectric films.
A Label-free Selected Reaction Monitoring Workflow Identifies a Subset of Pregnancy Specific Glycoproteins as Potential Predictive Markers of Early-onset Pre-eclampsia (2013)

Pre-eclampsia (PE) is a serious complication of pregnancy with potentially life threatening consequences for both mother and baby. Presently there is no test with the required performance to predict which healthy first-time mothers will go on to develop PE. The high specificity, sensitivity, and multiplexed nature of selected reaction monitoring holds great potential as a tool for the verification and validation of putative candidate biomarkersfor disease states. Realization of this potential involves establishing a high throughput, cost effective, reproducible sample preparation workflow. We have developed a semi-automated HPLC-based sample preparation workflow before a label-free selected reaction monitoring approach. This workflow has been applied to the search for novel predictive biomarkers for PE. To discover novel candidate biomarkers for PE, we used isobaric tagging to identify several potential biomarker proteins in plasma obtained at 15 weeks gestation from nulliparous women who later developed PE compared with pregnant women who remained healthy. Such a study generates a number of "candidate" biomarkers that require further testing in larger patient cohorts. As proof-of-principle, two of these proteins were taken forward for verification in a 100 women (58 PE, 42 controls) using label-free SRM. We obtained reproducible protein quantitation across the 100 samples and demonstrated significant changes in protein levels, even with as little as 20% change in protein concentration. The SRM data correlated with a commercial ELISA, suggesting that this is a robust workflow suitable for rapid, affordable, label-free verification of which candidate biomarkers should be taken forward for thorough investigation. A subset of pregnancy-specific glycoproteins (PSGs) had value as novel predictive markers for PE.
A Chimeric Toxin Vaccine Protects against Primary and Recurrent Clostridium difficile Infection (2012)

The global emergence of Clostridium difficile infection (CDI) has contributed to the recent surge in severe antibiotic-associated diarrhea and colonic inflammation. C. difficile produces two homologous glucosylating exotoxins, TcdA and TcdB, both of which are pathogenic and require neutralization to prevent disease occurrence. However, because of their large size and complex multifunctional domain structures, it has been a challenge to produce native recombinant toxins that may serve as vaccine candidates. Here, we describe a novel chimeric toxin vaccine that retains major neutralizing epitopes from both toxins and confers complete protection against primary and recurrent CDI in mice. Using a nonpathogenic Bacillus megaterium expression system, we generated glucosyltransferase-deficient holotoxins and demonstrated their loss of toxicity. The atoxic holotoxins induced potent antitoxin neutralizing antibodies showing little cross-immunogenicity or protection between TcdA and TcdB. To facilitate simultaneous protection against both toxins, we generated an active clostridial toxin chimera by switching the receptor binding domain of TcdB with that of TcdA. The toxin chimera was fully cytotoxic and showed potent proinflammatory activities. This toxicity was essentially abolished in a glucosyltransferase-deficient toxin chimera, cTxAB. Parenteral immunization of mice or hamsters with cTxAB induced rapid and potent neutralizing antibodies against both toxins. Complete and long-lasting disease protection was conferred by cTxAB vaccinations against both laboratory and hypervirulent C. difficile strains. Finally, prophylactic cTxAB vaccination prevented spore-induced disease relapse, which constitutes one of the most significant clinical issues in CDI. Thus, the rational design of recombinant chimeric toxins provides a novel approach for protecting individuals at high risk of developing CDI.
Table S4 from Anti-PSMA/CD3 Bispecific Antibody Delivery and Antitumor Activity Using a Polymeric Depot Formulation (2023)

&lt;p&gt;Mean pharmacokinetics parameters of BiJ591&lt;/p&gt;
Acyclic and Cyclic Di- and Tri(4-oxyphenyl-1,2-phenyleneethynylene)s:  Their Synthesis and Ferromagnetic Spin Interaction (1999)

A new set of π-conjugated and alternant but non-Kekulé-type di- and tri(1,2-phenyleneethynylene)s pendantly substituted with phenoxyl radicals at the 4 positions (1a, 2a, and 3a) was synthesized. The synthesis of these acyclic and cyclic compounds was achieved through the head-to-tail coupling of 2-bromo(or -iodo)-4-[3‘,5‘-di-tert-butyl-4‘-trimethylsiloxyl(or -hydroxy)phenyl]-1-ethynylbenzenes. The di- and triphenoxyl compounds (1a, and 2a and 3a) were triplet and quartet at the ground state, respectively, which was ascribed to a ferromagnetic coupling effect of the diphenyl ethynylene bridge for the pendant phenoxyls' spins. The cyclic π-conjugation in 3a exhibited a stronger effect on the spin alignment.
Diagnosis and epidemiological association of Listeria monocytogenes strains in two outbreaks of listerial encephalitis in small ruminants (1994)

Two outbreaks of epizootic listerial encephalitis, one in sheep and one in goats, were investigated through pathology, microbiology, and DNA amplification-based techniques. Efforts were made to survey the diversity of Listeria monocytogenes strains in the silage consumed by affected animals and to verify the causal relationship between silage and disease outbreak. In both outbreaks, L. monocytogenes was isolated from silage and brain tissue samples. Random amplified polymorphic DNA patterns revealed two distinct L. monocytogenes strains, one of which was identical to the sheep brain isolate, in the silage associated with the outbreak in sheep. Three brain isolates and one silage isolate, all of which had different random amplified polymorphic DNA patterns, were found in the outbreak involving goats. All isolates from both outbreaks were indistinguishable in an in vitro assay for cell-to-cell spread and growth in macrophages. All brain isolates from the goat outbreak had identical intracellular ActA patterns, which were different from the pattern for the silage isolate. While the sheep brain isolate had an ActA pattern different from that of the corresponding silage isolate, the patterns for the brain isolates from the two outbreaks were not identical. This survey demonstrates the diversity of L. monocytogenes in silage and suggests the existence of one or more selective processes by which certain strains are more prone to give rise to disease.
The skin barrier function gene SPINK5 is associated with challenge‐proven IgE‐mediated food allergy in infants (2017)

We report, for the first time, association between SPINK5 variant rs9325071 and challenge-proven IgE-mediated food allergy.
Perialveolar interstitial resistance and compliance in isolated rat lung (1991)

We have developed a method to characterize fluid transport through the perialveolar interstitium using micropuncture techniques. In 10 experiments we established isolated perfused rat lung preparations. The lungs were initially isogravimetric at 10 cmH2O arterial pressure, 2 cmH2O venous pressure, and 5 cmH2O alveolar pressure. Perialveolar interstitial pressure was determined by micropuncture at alveolar junctions by use of the servo-null technique. Simultaneously a second micropipette was placed in an alveolar junction 20-40 microns away, and a bolus of albumin solution (3.5 g/100 ml) was injected. The resulting pressure transient was recorded for injection durations of 1 and 4 s in nonedematous lungs. The measurements were repeated after gross edema formation induced by elevated perfusion pressure. We model the interstitium as a homogeneous linearly poroelastic material and assume the initial pressure distribution due to the injection to be Gaussian. The pressure decay is inversely proportional to time, with time constant T, where T is a measure of the ratio of interstitial tissue stiffness to interstitial resistance to fluid flow. A linear regression was performed on the reciprocal of the pressure for the decaying portion of the transients to determine T. Comparing pressure transients in nonedematous and edematous lungs, we found that T was 4.0 +/- 1.4 and 1.4 +/- 0.6 s, respectively. We have shown that fluid transport through the pulmonary interstitium on a local level is sensitive to changes in interstitial stiffness and resistance. These results are consistent with the decreased stiffness and resistance in the perialveolar interstitium that accompany increased hydration.
Extending Harmonic-Percussive Separation Of Audio Signals. (2014)

[TODO] Add abstract here.
Peroxisome proliferator-activated receptor-γin macrophage lipid homeostasis (2002)

The regulation of lipid and carbohydratemetabolism is essential for maintaining the energybalance of the body and enables cells to perform vitalfunctions. Improper control of these metabolicpathways can result in serious health problems,such as obesity-associated ‘metabolic syndrome’orsyndrome X, which is typified by increased risk ofcoronary artery diseases (CAD), diabetes andrelated problems, such as hypertension andlipidemia. The recent demonstration of commondietary lipids and their metabolites as signalingmolecules for nuclear orphan receptors provides aunique approach to the study of metabolichomeostasis at the molecular level. These orphanreceptors are proposed to control lipid homeostasisby regulating of the expression of genetic networksinvolved in lipid metabolism, transport, storage andelimination [1]. Examples of such lipid sensorsinclude receptors for fatty acids [peroxisomeproliferator-activated receptors (PPARs)], oxysterols[liver X receptors (LXRs)], bile acids [farnesoidXreceptor (FXR)] and xenobiotics [pregnaneXreceptor (PXR), steroid xenobiotic receptor (SXR)and constitutive androstane receptor (CAR)].The PPARs comprise three subtypes [PPAR α,PPARδ(or β) and PPAR γ] with distinct expressionpatterns and biological functions [2,3]. Dietary fattyacids and arachidonate metabolites are naturalactivators of this receptor subfamily. PPAR αispredominantly expressed in liver, heart, muscle andkidney, where it regulates fatty acid catabolism [4].Consistent with this notion, the fibrate class oflipid-lowering drugs, such as fenofibrate (Controlip®)and gemfibrozil (Lopid®), were found to be syntheticactivators of PPAR α[5–7]. PPAR γis enriched inadipocytes and macrophages and can be activated bythe thiazolidinedione (TZD) chemical class ofantidiabetic drugs [8–10], including rosiglitazone(Avandia®) and pioglitazone (Actos®). Molecular andgenetic studies have established roles for PPAR γinadipocyte differentiation, lipid storage and glucosehomeostasis [11–13]. PPAR δis expressed in mosttissues and has a less defined function. It isimplicated in lipid homeostasis, keratinocyteproliferation and wound healing, and is a candidatefor drug development [14–16].Much attention has focused on the roles of PPAR γand the effects of its ligands in macrophage biologyfollowing the discovery that agonists of PPAR γpromote lipid accumulation whilst suppressingcytokine-induced macrophage activation [17–20].These original studies implicated PPAR γin bothproatherogenic and antiatherogenic(anti-inflammatory) pathways mediated bycomponents of oxidized-low density lipoprotein(ox-LDL) and 15-deoxy- ∆
Automatic Control of Prosthetic Socket Size for People WithTranstibial Amputation: Implementation and Evaluation (2020)

Integration of the developed control system into everyday prostheses may improve quality of life of prosthesis users by relieving them of the burden of continually adjusting socket size to maintain fit.