gebhart/patrepeval huggingface dataset:
Visualizing Structure and Dynamics of Disaccharide Simulations (2012)

We examine the effect of several solvent models on the conformational properties and dynamics of disaccharides such as cellobiose and lactose. Significant variation in timescale for large scale conformational transformations are observed. Molecular dynamics simulation provides enough detail to enable insight through visualization of multidimensional data sets. We present a new way to visualize conformational space for disaccharides with Ramachandran plots.
Measurement of Higgs boson production in the diphoton decay channel in pp collisions at center-of-mass energies of 7 and 8 TeV with the ATLAS detector (2014)

A measurement of the production processes of the recently discovered Higgs boson is performed in the two-photon final state using 4.5fb-1 of proton-proton collisions data at s=7TeV and 20.3fb-1 at s=8TeV collected by the ATLAS detector at the Large Hadron Collider. The number of observed Higgs boson decays to diphotons divided by the corresponding Standard Model prediction, called the signal strength, is found to be _=1.17±0.27 at the value of the Higgs boson mass measured by ATLAS, mH=125.4GeV. The analysis is optimized to measure the signal strengths for individual Higgs boson production processes at this value of mH. They are found to be _ggF=1.32±0.38, _VBF=0.8±0.7, _WH=1.0±1.6, _ZH=0.1-0.1+3.7, and _ttÀH=1.6-1.8+2.7, for Higgs boson production through gluon fusion, vector-boson fusion, and in association with a W or Z boson or a top-quark pair, respectively. Compared with the previously published ATLAS analysis, the results reported here also benefit from a new energy calibration procedure for photons and the subsequent reduction of the systematic uncertainty on the diphoton mass resolution. No significant deviations from the predictions of the Standard Model are found.
Fine Structure of Detached Coils Observed by Micro-CT (2004)

Detached GDC was observed by high resolutional industrial microCT, whose resolution was higher than 0.1 mm. Unexpected destruction of the coils (kinking) was detected and unraveling also clearly visualized. Much higher resolution can improve safe and effectivity of GDC procedure.
Bayesian Active Learning for Radiation Pattern Sampling Over Cylindrical Surfaces (2022)

In this article, a new motion-aware sampling strategy (MASS) is presented to speed up the measurement of radiation patterns around cylindrical surfaces. Differently from preexisting sampling techniques, the MASS directly chooses positions that reduce the overall travel time of the field antenna, rather than minimizing the total number of samples. The proposed strategy employs a Gaussian process model that is adapted to the field over a cylindrical surface. Moreover, a new acquisition function for Bayesian active learning is developed in order to efficiently search the peaks of the measured field and predict their values. Next, the proposed strategy is tested on the experimental data from a radiation pattern of a comb generator. Finally, the results are compared to standard grid sampling and Bayesian optimization strategies.
A Passive UHF RFID Dielectric Sensor for Aqueous Electrolytes (2019)

The one-step modification of a commercial RFID sensing tag is demonstrated using polydimethylsiloxane-based thin-film chemistry to construct reusable passive RFID sensors for changes in the dielectric properties of electrolyte solutions as a function of concentration. The effects of PDMS film thickness were characterized as a function of RFID sensor code value. The output sensor code of the RFMicron RFM2100-AER wireless flexible moisture sensor (taken between 800 and 860 MHz) was compared with the readings taken when the tag was dry and when the tag had a water deposition on the sensor area. The effect of the direct application of liquid water on the tag was to alter the capacitance presented to the integrated chip which auto-tunes to correct for the reactance. By varying the thickness of the PDMS film between the interdigitated sensor and deposited liquid, the sensitivity of the tag to a high dielectric medium could be controlled. Aqueous salt solutions were tested on a 500-μm-thick film. It was found that the sensing platform could be used as a means of measuring the concentration of various salt solutions within the range 0-2 M and in turn could be used as a passive UHF RFID dielectric measuring tool. The measurement capability of the platform was subsequently demonstrated using a reduced frequency range (845-865 MHz).
Decoding mixed emotions from expression map of face images (2013)

In real life facial expressions show mixture of emotions. This paper proposes a novel expression descriptor based expression map that can efficiently represent pure, mixture and transition of facial expressions. The expression descriptor is the integration of optic flow and image gradient values and the descriptor value is accumulated in temporal scale. The expression map is realized using self-organizing map. We develop an objective scheme to find the percentage of different prototypical pure emotions (e.g., happiness, surprise, disgust etc.) that mix up to generate a real facial expression. Experimental results show that the expression map can be used as an effective classifier for facial expressions.
Poster abstract: supporting heterogeneous LCD/camera links (2014)

Visible light communication over LCD/camera links offers a potential complement to traditional RF communication technology such as WiFi or cellular networks. However, the heterogeneity in receivers (e.g., mobile phone cameras) presents a challenge because the receivers differ widely in resolution, distance to the transmitter (LCD), and other factors, and therefore they differ in channel quality. We are researching a communication scheme in which each receiver can decode as much data from an LCD's transmission as the receiver's channel supports. The core idea is to encode the payload into an image's frequency representation rather than directly into pixels. We have successfully transmitted data using a prototype implementation and are currently investigating appropriate channel models.
The Use of N‐Type Ligands in the Enantioselective Liquid–Liquid Extraction of Underivatized Amino Acids (2010)

Abstract The first palladium based extraction system using chiral N ‐based ligands in the enantioselective liquid–liquid extraction (ELLE) of underivatized amino acids, is presented. The system shows the highest selectivity for the ELLE of methionine with metal complexes as hosts reported to date. Furthermore, the host can be prepared in situ from commercially available compounds. The dependency of the system on parameters such as pH, organic solvent, and temperature has been established. The intrinsic selectivity was deduced by determination of the association constants of the palladium complex with the tryptophan enantiomers.
Results of a model on nerve compound action signals near a nerve crush (2003)

Deconvolution of compound action signals (CASs) measured from peripheral nerve bundles results in clinically valuable construction velocity distributions (CVDs). This procedure requires stationary propagation of action potentials in the nerve bundle. Regeneration of surgically reconstructed nerve bundles can be monitored by means of the measured CAS distal from the repair site. The discontinuous propagation of action potentials in a regenerating nerve bundle requires essential changes in the CAS deconvolution. A method of incorporating these changes in a CAS deconvolution model is described for a simplified termination of action potential propagation near a cut end of a nerve bundle.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
An integrated texton and bag of words classifier for identifying anaplastic medulloblastomas. (2011)

In this paper we present a combined Bag of Words and texton based classifier for differentiating anaplastic and non-anaplastic medulloblastoma on digitized histopathology. The hypothesis behind this work is that histological image signatures may reflect different levels of aggressiveness of the disease and that texture based approaches can help discriminate between more aggressive and less aggressive phenotypes of medulloblastoma. The bag of words approach attempts to model the occurrence of differently expressed image features. In this work we choose to model the image features via textons which can quantitatively capture and model texture appearance in the images. The texton-based features, obtained via two methods, the Haar Wavelet responses and MR8 filter bank, provide spatial orientation and rotation invariant attributes. Applying these features to the bag of words framework yields textural representations that can be used in conjunction with a classifier (κ-nearest neighbor) or a content based image retrieval system. Over multiple runs of randomized cross validation, a κ-NN classifier in conjunction with Haar wavelets and the texton, bag of words approach yielded a mean classification accuracy of 80, an area under the precision recall curve of 87 and an area under the ROC curve of 83 in distinguishing between anaplastic and non-anaplastic medulloblastomas on a cohort of 36 patient studies.
EFFECTS OF MECHANICAL RECYCLING ON CARBON FIBER-BASED HYBRID COMPOSITES (2023)

Carbon fiber (CF) reinforced composites are high-performing, highly utilized material systems historically used in aerospace. As the cost of CF decreases, other industries, such as automotive and energy generation, seek to adopt CF composites into their applications. A sudden increase in CF demand may create supply chain issues if the adoption happens without scaling up of the CF production. A solution for reducing the reliance on CF is to substitute some portion of the CF content with another fiber type without significantly reducing the material properties. When multiple reinforcing fillers are introduced into a composite system, the materials system is often referred to as a hybrid composite and in this case a CF-based hybrid composite. To further relieve reliance on CF and with sustainable manufacturing becoming more prominent in industry, mechanical recycling can be employed to replace all or a percentage of the virgin material content. Utilizing recycled content in place of virgin content will further aid in reducing the reliance on virgin CF and decrease overall material costs. Here, the effects of utilizing mechanically recycled feedstocks on the mechanical properties of injection molded samples are explored to understand the feasibility of re-manufacturing recycled CF-based hybrid composites. By determining the mechanical properties and mechanisms in which the properties change through varying recycled content, the assessment of how the material will perform in other manufacturing processes can be inferred. As a result, industry will gain better insight into utilizing mechanically recycled feedstocks to reduce their reliance on the CF supply chain.
B7-2 Expressed on EL4 Lymphoma Suppresses Antitumor Immunity by an Interleukin 4–dependent Mechanism (1999)

For T cells to become functionally activated they require at least two signals. The B7 costimulatory molecules B7-1 and B7-2 provide the "second signal" pivotal for T cell activation. In this report, we studied the relative roles of B7-1 and B7-2 molecules in the induction of antitumor immunity to the T cell thymoma, EL4. We generated EL4 tumor cells that expressed B7-1, B7-2, and B7-1+B7-2 by transfecting murine cDNAs. Our results demonstrate that EL4-B7-1 cells are completely rejected in syngeneic mice. Unlike EL4-B7-1 cells, we find that EL4-B7-2 cells are not rejected but progressively grow in the mice. A B7-1- and B7-2-EL4 double transfectant was generated by introducing B7-2 cDNA into the EL4-B7-1 tumor line that regressed in vivo. The EL4-B7-1+B7-2 double transfectant was not rejected when implanted into syngeneic mice but progressively grew to produce tumors. The double transfectant EL4 cells could costimulate T cell proliferation that could be blocked by anti-B7-1 antibodies, anti-B7-2 antibodies, or hCTLA4 immunoglobulin, showing that the B7-1 and B7-2 molecules expressed on the EL4 cells were functional. In vivo, treatment of mice implanted with double-transfected EL4 cells with anti-B7-2 monoclonal antibody resulted in tumor rejection. Furthermore, the EL4-B7-2 and EL4-B7-1+B7-2 cells, but not the wild-type EL4 cells, were rejected in interleukin 4 (IL-4) knockout mice. Our data suggests that B7-2 expressed on some T cell tumors inhibits development of antitumor immunity, and IL-4 appears to play a critical role in abrogation of the antitumor immune response.
Network-based integrative analysis of lithium response in bipolar disorder using transcriptomic and GWAS data (2022)

Abstract Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there is presently no way to predict response to guide treatment. The aim of this study is to identify functional genes and pathways that distinguish BD Li responders (LR) from BD Li non-responders (NR). An initial Pharmacogenomics of Bipolar Disorder study (PGBD) GWAS of lithium response did not provide any significant results. As a result, we then employed network-based integrative analysis of transcriptomic and genomic data. In transcriptomic study of iPSC-derived neurons, 41 significantly differentially expressed (DE) genes were identified in LR vs NR regardless of lithium exposure. In the PGBD, post-GWAS gene prioritization using the GWA- boosting (GWAB) approach identified 1119 candidate genes. Following DE-derived network propagation, there was a highly significant overlap of genes between the top 500- and top 2000-proximal gene networks and the GWAB gene list ( P hypergeometric =1.28E- 09 and 4.10E-18, respectively). Functional enrichment analyses of the top 500 proximal network genes identified focal adhesion and the extracellular matrix (ECM) as the most significant functions. Our findings suggest that the difference between LR and NR was a much greater effect than that of lithium. The direct impact of dysregulation of focal adhesion on axon guidance and neuronal circuits could underpin mechanisms of response to lithium, as well as underlying BD. It also highlights the power of integrative multi-omics analysis of transcriptomic and genomic profiling to gain molecular insights into lithium response in BD.
Tissue Self-Affinity and Polarized Light Scattering in the Born Approximation: A New Model for Precancer Detection (2006)

Light scattered from biological tissues can exhibit an inverse power law spectral component. We develop a model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index to account for this. The model is applied to light scattering spectra obtained from excised esophagi of normal and carcinogen-treated rats. Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer.
A Multi-Element Detector System for Intelligent Imaging: I-ImaS (2006)

I-ImaS is a European project aiming to produce new, intelligent X-ray imaging systems using novel APS sensors to create optimal diagnostic images. Initial systems concentrate on mammography and encephalography. Later development will yield systems for other types of radiography such as industrial QA and homeland security. The I-ImaS system intelligence, due to APS technology and FPGAs, allows real-time analysis of data during image acquisition, giving the capability to build a truly adaptive imaging system with the potential to create images with maximum diagnostic information within given dose constraints. A companion paper deals with the DAQ system and preliminary characterization. This paper considers the laboratory X-ray characterization of the detector elements of the I-ImaS system. The characterization of the sensors when tiled to form a strip detector will be discussed, along with the appropriate correction techniques formulated to take into account the misalignments between individual sensors within the array. Preliminary results show that the detectors have sufficient performance to be used successfully in the initial mammographic and encephalographic I-ImaS systems under construction and this paper will further discuss the testing of these systems and the iterative processes used for intelligence upgrade in order to obtain the optimal algorithms and settings.
Composition of Functional Lipids in Hulled and Hulless Barley in Fractions Obtained by Scarification and in Barley Oil (2007)

ABSTRACT Two cultivars of hulled barley (Thoroughbred and Nomini) and two cultivars of hulless barley (Doyce and Merlin) were scarified to abrade the outer layers of hull and pericarp. The resulting scarification fines fractions were evaluated as potential sources of functional lipids (phyto‐sterols, tocopherols, and tocotrienols). The levels of total phytosterols and total tocotrienols in the barley scarification fine fractions were probably not high enough to justify their use as functional foods. However, the levels of total phytosterols and total tocotrienols in the oils extracted from both whole kernels and scarified fines were both sufficiently high to make it reasonable to consider their potential use as new functional oils. Indeed, the levels of total tocotrienols in barley oils (2,911–6,126 mg/kg of oil) are several‐fold higher than those reported in two other oils that are being marketed as high in tocotrienols: palm oil (530 mg/kg) and rice bran oil (770 mg/kg). The levels of total phytosterols in barley oils range from 1.20 to 9.60 g/100 g of oil.
<title>High-sensitive photopolymer for large-size holograms</title> (1991)

The photopolymer comprising the matrix polymer, polyfunctionalmonomer, radical initiator, and sensitizing dye are sensitive to visible light to give the holographic recording material for an argon ion laser exposure. The radical exposure involves 3, 3', 4, 4'- tetrakis(t-butyloxycarbonyl)benzophenone(BTTB, I) and iron-arene complex (II), and the sensitizing dye is ketocoumarin(III). The photopolymer gave the sensitivity from 0.1-4 mJ/cm2, depending on the holographic recording angle, for 488 nm argon ion laser light. Large-size rainbow holograms, 50 cm X 40 cm, were successfully recorded with this photopolymer with 10 sec exposure.
A New Cell-Selective Three-Dimensional Microincubator Based on Silicon Photonic Crystals (2012)

In this work, we show that vertical, high aspect-ratio (HAR) photonic crystals (PhCs), consisting of periodic arrays of 5 µm wide gaps with depth of 50 µm separated by 3 µm thick silicon walls, fabricated by electrochemical micromachining, can be used as three-dimensional microincubators, allowing cell lines to be selectively grown into the gaps. Silicon micromachined dice incorporating regions with different surface profiles, namely flat silicon and deeply etched PhC, were used as microincubators for culturing adherent cell lines with different morphology and adhesion properties. We extensively investigated and compared the proliferative behavior on HAR PhCs of eight human cell models, with different origins, such as the epithelial (SW613-B3; HeLa; SW480; HCT116; HT29) and the mesenchymal (MRC-5V1; CF; HT1080). We also verified the contribution of cell sedimentation into the silicon gaps. Fluorescence microscopy analysis highlights that only cell lines that exhibit, in the tested culture condition, the behavior typical of the mesenchymal phenotype are able to penetrate into the gaps of the PhC, extending their body deeply in the narrow gaps between adjacent silicon walls, and to grow adherent to the vertical surfaces of silicon. Results reported in this work, confirmed in various experiments, strongly support our statement that such three-dimensional microstructures have selection capabilities with regard to the cell lines that can actively populate the narrow gaps. Cells with a mesenchymal phenotype could be exploited in the next future as bioreceptors, in combination with HAR PhC optical transducers, e.g., for label-free optical detection of cellular activities involving changes in cell adhesion and/or morphology (e.g., apoptosis) in a three-dimensional microenvironment.
Surgical correction for Tessier number 7 craniofacial cleft using a medially overcorrected design (2019)

For the successful correction of macrostomia, plastic surgeons should consider both functional and aesthetic problems of the lip. Adequate repair of the orbicularis oris muscle, skin closure with Z-plasty, and medial overcorrection of the neo-oral commissure led to good results in our patients.
Optical Control of Adenosine A3 Receptor Signaling: Towards a Multimodal Phototherapy in Psoriasis? (2022)

OPINION article Front. Immunol., 29 April 2022Sec. Cytokines and Soluble Mediators in Immunity Volume 13 - 2022 | https://doi.org/10.3389/fimmu.2022.904762
Development of chemical sensor arrays for harsh environments and aerospace applications (2003)

The aerospace industry requires the development of a range of chemical sensor technologies for such applications as fuel leak detection, fire detection, and emission monitoring. A range of chemical sensors are being developed based on: 1) Micromachining and microfabrication technology, 2) The use of nanocrystalline materials, and 3) The development of high temperature semiconductors, especially silicon carbide. However, due to issues of selectivity and cross-sensitivity, individual sensors are limited in the amount of information that they can provide in environments that contain multiple chemical species. Thus, sensor arrays are being developed to address detection needs in such multi-species environments. This paper discusses the sensor array development for harsh environment and aerospace applications such as leak and fire detection as well as emissions monitoring. Application of these arrays as well as their relative stage of development will be addressed.
Reduction of fluconazole susceptibility of Candida albicans in APECED patients due to long-term use of ketoconazole and miconazole (2008)

We have analysed further the y of usage of antifungals in autoimmune polyendocrinopathy - candidiasis - ectodermal dystrophy (APECED) patients and its impact on the susceptibility to fluconazole in Candida albicans. Data were obtained from patient records up to 30 y earlier. Analysing the use of azoles preceding isolation of each isolate showed that significantly more y of azole usage preceded isolation of C. albicans with decreased susceptibility to fluconazole than isolation of susceptible isolates. This was found to be mainly due to the usage of azoles other than fluconazole. Significantly more y of usage of ketoconazole and miconazole preceded the isolation of strains with decreased susceptibility to fluconazole than susceptible isolates (p=0.0241 and 0.0012, respectively). These results highlight that also topical compounds, in particular miconazole, may influence fluconazole susceptibility. Our data indicate that discretion should be used in the long-term use of all azoles, including topical miconazole. At the same time topical amphotericin B appears to be a safe choice as resistance is very rare despite y of usage.
Impact of WDM Channel Count on Nonlinear Effects in MDM Transmission Systems (2017)

We vary the number of WDM channels and investigate the impact on the nonlinear effects in mode-division multiplexed transmissions. The OSNR requirements for 15 spatial modes and up to 80 WDM channels are evaluated.