gebhart/patrepeval huggingface dataset:
Approaches to the Synthesis of the Vancomycin Antibiotics. Synthesis of Orienticin C (Bis-dechlorovancomycin) Aglycon (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTApproaches to the Synthesis of the Vancomycin Antibiotics. Synthesis of Orienticin C (Bis-dechlorovancomycin) AglyconDavid A. Evans, James C. Barrow, Paul S. Watson, Andrew M. Ratz, Christopher J. Dinsmore, Deborah A. Evrard, Keith M. DeVries, Jonathan A. Ellman, Scott D. Rychnovsky, and Jérôme LacourView Author Information Department of Chemistry and Chemical Biology Harvard University, Cambridge, Massachusetts 02138 Cite this: J. Am. Chem. Soc. 1997, 119, 14, 3419–3420Publication Date (Web):April 9, 1997Publication History Received27 December 1996Published online9 April 1997Published inissue 1 April 1997https://pubs.acs.org/doi/10.1021/ja964420thttps://doi.org/10.1021/ja964420trapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1343Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amides,Antimicrobial agents,Cyclization,Ethers,Redox reactions Get e-Alerts
(Un)linkable Pseudonyms for Governmental Databases (2015)

When data maintained in a decentralized fashion needs to be synchronized or exchanged between different databases, related data sets usually get associated with a unique identifier. While this approach facilitates cross-domain data exchange, it also comes with inherent drawbacks in terms of controllability. As data records can easily be linked, no central authority can limit or control the information flow. Worse, when records contain sensitive personal data, as is for instance the case in national social security systems, such linkability poses a massive security and privacy threat. An alternative approach is to use domain-specific pseudonyms, where only a central authority knows the cross-domain relation between the pseudonyms. However, current solutions require the central authority to be a fully trusted party, as otherwise it can provide false conversions and exploit the data it learns from the requests. We propose an (un)linkable pseudonym system that overcomes those limitations, and enables controlled yet privacy-friendly exchange of distributed data. We prove our protocol secure in the UC framework and provide an efficient instantiation based on discrete-logarithm related assumptions.
Compensation splitting scheme for dealing with dispersion and self-phase modulation in communication systems (1996)

In optical communication systems, the use of alternating dispersion is a common way to deal with bit-rate limitations caused by dispersive pulse broadening. An alternative to this technique was proposed by Yariv et al [1] some time ago. It was suggested that a phase-conjugate conversion of the signal at the middle of the propagation length would cancel, at the line output, the accumulated dispersive effects over the first half propagation. Although more complicated than the first technique, this approach has the advantage of also being able to compensate for the self-phase modulation effects incurred through the Kerr nonlinearity of silica fibers, as first demonstrated experimentally by Watanabe et al [2].
Platelet-Rich Plasma Differs According to Preparation Method and Human Variability (2012)

Single-step procedures are capable of producing sufficient amounts of platelets for clinical usage. Within the evaluated procedures, platelet numbers and numbers of white blood cells differ significantly. The intra-individual results of platelet-rich plasma separations showed wide variations in platelet and cell numbers as well as levels of growth factors regardless of separation method.
Droplet flow cytometry for single-cell analysis (2021)

The interrogation of single cells has revolutionised biology and medicine by providing crucial unparalleled insights into cell-to-cell heterogeneity. Flow cytometry (including fluorescence-activated cell sorting) is one of the most versatile and high-throughput approaches for single-cell analysis by detecting multiple fluorescence parameters of individual cells in aqueous suspension as they flow past through a focus of excitation lasers. However, this approach relies on the expression of cell surface and intracellular biomarkers, which inevitably lacks spatial and temporal phenotypes and activities of cells, such as secreted proteins, extracellular metabolite production, and proliferation. Droplet microfluidics has recently emerged as a powerful tool for the encapsulation and manipulation of thousands to millions of individual cells within pico-litre microdroplets. Integrating flow cytometry with microdroplet architectures surrounded by aqueous solutions (<i>e.g.</i>, water-in-oil-in-water (W/O/W) double emulsion and hydrogel droplets) opens avenues for new cellular assays linking cell phenotypes to genotypes at the single-cell level. In this review, we discuss the capabilities and applications of droplet flow cytometry (DFC). This unique technique uses standard commercially available flow cytometry instruments to characterise or select individual microdroplets containing single cells of interest. We explore current challenges associated with DFC and present our visions for future development.
Supplementary Results from The MD Anderson Prostate Cancer Patient-derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-driven Therapy Development (2023)

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ARTHROSCOPIC EVALUATION AND TREATMENT OF PROBLEMATIC TOTAL KNEE PROSTHESIS: A RETROSPECTIVE STUDY OF 44 CASES (2005)

Introduction and Aims: The purpose of our study was to review our experience with the use of arthroscopy for the diagnosis and management of patients with problematic total knee replacements (TKRs). Method: Forty-four patients were retrospectively reviewed to evaluate clinical and diagnostic efficacy of arthroscopy of TKR. Results: Six patients with soft-tissue impingement had good-excellent outcome. Three patients had lateral retinacular release to correct patellar subluxation. Arthroscopic treatment of infection in two patients with significant comorbidities was able to control infection in one patient. Of the 13 patients with decreased range of motion due to intra-articular scarring, only four maintained increased motion. Of the 20 patients who had arthroscopy as a diagnostic procedure, 15 were successfully diagnosed and treated. Of the 10 patients with knee pain as the primary complaint, an intra-articular cause of the knee pain was identified in five patients and successfully treated in four, while no diagnosis was made in the remaining five patients. Conclusion: The use of arthroscopy for the diagnosis and treatment of the problematic TKA is an effective and safe procedure when performed for specific indications. We found adhesiolysis of limited value for patients with decreased range of motion due to dense scar tissue.
A Novel Fault-Tolerant Control Method for Modular Multilevel Converter with an Improved Phase Disposition Level-Shifted PWM (2019)

This paper proposes a novel fault-tolerant control method for modular multilevel converter (MMC) with an improved level-shifted carrier PWM, based on the concept of virtual voltage. First, an improved phase disposition level-shifted (PD-LS) PWM with only one carrier in each arm is adopted. Then, based on the virtual voltage idea, a simplified control method is proposed to realize fault-tolerant operation without carriers reconfiguration. Compared with traditional fault-tolerant control methods, due to the reduced carriers generation and decreased comparisons between carriers and modulation waves, the modulation process of the proposed scheme can be dramatically simplified during both the pre-fault and the post-fault process. The effectiveness of the proposed method is verified by simulation and experiment results.
Mechanical Properties and Internal Stress in the Vapor Deposited (Ti(C,N)) Film Estimated by the Quantitative Analysis of AE Waves Emitted During the Loading. (1995)

The objective of this study is to examine the mechanical strength of ARE-deposited Ti (C, N) film by using acoustic emission (AE) source characterization under tensile and compressive loading. Threshold stress in the substrate steel causes Mode-I fractures in the film as determined by quantitative source inversion of AE signals emitted from the limited Ti (C, N) area with a uniform stress distribution. Film fractures were invariably associated with the emergence of slip steps in the substrate steel. The threshold stress for film fractures under tensile loading was almost 9times greater than the stress under compressive loading.A simple method for estimating internal stresses in film from threshold stresses under different loading was also proposed. The internal stress in the film, estimated from the maximum strain criterion, was -3.8GPa which coincided with the reported internal stress measured using X rays.
ChemInform Abstract: STUDIES ON 1‐SUBSTITUTED 4‐(1,2‐DIPHENYLETHYL)PIPERAZINE DERIVATIVES AND THEIR ANALGESIC ACTIVITIES. 2. STRUCTURE‐ACTIVITY RELATIONSHIPS OF 1‐CYCLOALKYL‐4‐(1,2‐DIPHENYLETHYL)PIPERAZINES (1979)

Abstract 46 Piperazine der Struktur (I) werden dargestellt und nach der D′Amour‐Smith‐Methode auf analgetische Wirkung untersucht.
PERIFUSIONAL TECHNIQUES FOR SCREENING ANTIBODIES (Ab) IN LIVING TISSUE. (1983)

UCD Medical Center, Sacramento, CA and Northwestern Univ., Chicago, IL. Supported by DOE Grant DE ATO3-82, ACS Grant PDT-94F and UC Cancer Coord. Committee.
On real-time smart meter reading using OFDMA-based random access (2014)

Real-time transmission of smart meter measurement data is investigated. A contention based approach exploiting the unused cellular spectrum, e.g. of 4G Long Term Evolution (LTE), is proposed. The proposed approach uses subsets of LTE resource blocks (RBs) as allocation units. It is based on channel aware reservation slotted Aloha over orthogonal frequency division multiple access (OFDMA) using time/frequency slots, which leads to a reduction of collision probability, prevents collisions in the transmission phase, and allows detecting these collisions at the reservation phase. Simulation results show that a large number of smart meters can be successfully accommodated within a limited coverage area with the proposed approach, while transmitting their measurement data in real-time.
U-jrelationship in type-II superconductors (1993)

The Anderson-Kim model has been modified in terms of the U-j relationship for high-${\mathit{T}}_{\mathit{c}}$ superconductors. We have obtained U-j curves by an approach based on the temperature dependence of ${\mathit{j}}_{\mathit{c}}$. Our results are consistent with the physical picture of flux creep. Our data is obtained from magnetic-relaxation experiments on ${\mathrm{YBa}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{\mathit{x}}$ single crystals with the direction of the field parallel to the c axis. The decay of magnetization was studied for both increasing and decreasing fields, used to obtain the current density.
Magnetic resonance imaging-compatible circular mapping catheter: anin vivofeasibility and safety study (2016)

This new MR-compatible 10-pole catheter appears to be safe and effective. Combining MR and multipolar EP in a single session offers the possibility to correlate substrate information (scar, fibrosis) and EP mapping as well as online monitoring of lesion formation and electrical endpoint.
Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry (2021)

Understanding broadly neutralizing sarbecovirus antibody responses is key to developing countermeasures effective against SARS-CoV-2 variants and future spillovers of other sarbecoviruses. Here we describe the isolation and characterization of a human monoclonal antibody, designated S2K146, broadly neutralizing viruses belonging to all three sarbecovirus clades known to utilize ACE2 as entry receptor and protecting therapeutically against SARS-CoV-2 beta challenge in hamsters. Structural and functional studies show that most of the S2K146 epitope residues are shared with the ACE2 binding site and that the antibody inhibits receptor attachment competitively. Viral passaging experiments underscore an unusually high barrier for emergence of escape mutants making it an ideal candidate for clinical development. These findings unveil a key site of vulnerability for the development of a next generation of vaccines eliciting broad sarbecovirus immunity.
Advances and Challenges in Log Analysis (2011)

Computer-system logs provide a glimpse into the states of a running system. Instrumentation occasionally generates short messages that are collected in a system-specific log. The content and format of logs can vary widely from one system to another and even among components within a system. A printer driver might generate messages indicating that it had trouble communicating with the printer, while a Web server might record which pages were requested and when.
A hybrid numerical/analytic technique for the computation of wave fields in stratified media based on the Hankel transform (1984)

A hybrid numerical/analytic technique for computing the field due to a monochromatic point source in a horizontally stratified medium was developed. This procedure is extremely accurate for all ranges. It is particularly appropriate when the field is composed of few dominant modes and a significant contribution from the continuous spectrum. This is the case for long-range propagation in the deep ocean when the source and receiver are near the bottom and there is a low speed layer at the water-bottom interface. The method is based upon a numerical evaluation of the Sommerfeld integral, which is in the form of a Hankel transform. Both computational speed and high accuracy are obtained by treating the singularities in the kernel of the Sommerfeld integral with a new technique that allows the singular portions to be handled analytically but which keeps the remaining portion of the integral well behaved numerically. The treatment of these singularities was motivated by a study of the effects of aliasing in the Hankel transform. Both speed and accuracy in the calculation of the Hankel transform are obtained by applying a new fast (N * log N) Hankel transform algorithm that requires its input on a square root grid. This grid is more suitable for representation of the kernel of the Sommerfeld integral than more conventional linear grids. The algorithm has significant speed advantages over quadrature and adaptive integration techniques.
Semi-Active Control Laws - Optimal and Sub-Optimal (1994)

SUMMARY This paper attempts to clarify the question of what the optimal semi-active suspension is that minimizes a deterministic quadratic performance index. The optimal control law is a time-varying solution that involves three related Riccati equations. The constant Riccati solution (the so-called “clipped optimal” solution) is not optimal, although its performance is generally quite close to that of the time-varying solution. As the time-varying solution cannot be practically implemented, several constant gain sub-optimal solutions are investigated. A new semi-active algorithm, called the “steepest gradient” algorithm, is developed and its performance is shown to be superior to that of the “clipped optimal” solution.
Pathologic Complete Response Predicts Recurrence-Free Survival More Effectively by Cancer Subset: Results From the I-SPY 1 TRIAL—CALGB 150007/150012, ACRIN 6657 (2012)

In this biologically high-risk group, pCR differs by receptor subset. pCR is more highly predictive of RFS within every established receptor subset than overall, demonstrating that the extent of outcome advantage conferred by pCR is specific to tumor biology.
Glyoxylic Acid as Reducing Agent for Electroless Copper Deposition on Cobalt Liner (2015)

Electroless deposition of Cu was investigated on thin Co layer for through Si via with high aspect ratio structure. The electroless deposition bath was optimized for minimizing Co corrosion during Cu nucleation by using electrochemical analysis. Glyoxylic acid, which is known as non-toxic reducing agent for electroless Cu deposition, showed anodic oxidation on Co, which did not appear for the case of formaldehyde. Furthermore, ratio of complexing agent and Cu ion also impacted Co corrosion; free complexing agent in the electroless deposition bath accelerated corrosion of Co. The optimized electroless bath which contained glyoxylic acid as reducing agent and non-free EDTA performed in 3 μm × 50 μm TSV, the electroless deposited Cu layer could serve as a seed layer for TSV filling by electrodeposition. The electroless Cu layer was continuously deposited without missing of continuity of Co layer even close to the bottom of TSV.
Characteristics and Sintering Behavior of Barium Titanate Powder Synthesized by Emulsion Combustion Method. (2001)

Barium titanate (BaTiO3) powder was synthesized using the emulsion combustion method (ECM) from a water-in-oil-type emulsion, in which a barium nitrate aqueous solution, a titania sol, kerosene and a surfactant were included, at a firing temperature of 850°C. Particle characteristics and sintering behavior of the synthesized particles were evaluated. The particles of the synthesized powder were nearly spherical in shape, 200-500nm in diameter and polycrystalline. The diameter of the particle was almost consistent with that calculated from the size of the aqueous microsphere in the emulsion, the concentration of metal ions and the density of BaTiO3. The X-ray diffraction (XRD) pattern showed that the main product (over 95%) was BaTiO3 and that a small amount of Ba2TiO4 was synthesized. The compact of the synthesized powder was densified up to 90% of the theoretical density at a sintering temperature of 1200°C, which was 100°C lower than that of the powder produced by the hydrothermal process. The fine polycrystalline structure of the ECM-made particles was considered to enhance the densification at a lower temperature. The sintered specimen showed a typical temperature dependence of dielectric constant in BaTiO3, which included two peaks at 20 and 120°C, corresponding to orthorhombic-tetragonal and tetragonal-cubic phase transitions, respectively.
Temporal prediction and differential coding of motion vectors in the MCTF framework (2004)

Motion compensated temporal filtering (MCTF) is used in wavelet video coding schemes to remove temporal redundancy. Current extensions to MCTF use bi-directional filtering and multiple reference frames to improve the coding performance significantly. However, these extensions lead to an additional cost of coding extra sets of motion vectors. In this paper we propose the use of temporal prediction to reduce the bits needed to code motion vectors. We describe several temporal prediction methods, and highlight the advantages of each scheme. We also use MV prediction during motion estimation, i.e. change the search center and the search range based on the temporal prediction, and describe the tradeoffs to be made between rate, distortion, and complexity. We perform several experiments to illustrate the gains of using temporal prediction, and identify the content dependent nature of such results.
Other Reactions of Allylpalladium and Related Derivatives: Cycloaddition Reactions of Allylpalladium and Related Derivatives (2005)

This chapter presents two major topics that pertain to nucleophilic attack on ligands of organopalladium complexes: the Tsuji–Trost reaction and the Wacker oxidation reaction. Related reactions of allylpalladium derivatives and reactions involving Pd π-complexes are also discussed. A brief overview of the well-established chemistry of Pd-catalyzed carbon–carbon bond-forming reactions involving allylic and propargylic compounds is outlined. Because of their special significance in organic synthesis, Pd-catalyzed asymmetric allylation and related reactions are also presented. A discussion of the synthesis of natural products via allylpalladium and related derivatives is included.
Early-career research education mentoring: a successful program in NeuroHIV and mental health (TRNAMH) (2023)

the virus was identified in the late 1980s.Forty years ago, people presenting with clinical symptoms, including severe subcortical cognitive impairment, movement disorders, typically bradykinesia, and gait abnormalities with or without behavioral symptoms, were diagnosed with acquired immune deficiency syndrome (AIDS) dementia complex (ADC).ADC became the first described and clinically used definition of AIDS [1-3] (Figure 1).It was also recognized that HIV affected the spinal cord resulting in a vacuolar myelopathy and peripheral nerve small fiber neuropathy with several scientists at Johns Hopkins contributing to seminal findings to the latter [4-8].In the decades since the start of the HIV pandemic, scientific innovations in testing, Open Access.
Neoadjuvant checkpoint inhibition in renal cell carcinoma associated Stauffer's syndrome (2019)

Stauffer's syndrome is a paraneoplastic phenomenon associated with renal cell carcinoma (RCC) characterized by cholestatic hepatitis. We explore the effects of perioperative immunotherapy in a case of Stauffer's syndrome. A 70-year-old female with a locally advanced clear cell RCC (ccRCC) developed severe hyperbilirubinemia. The patient's cholestasis progressed despite initial systemic immunotherapy, but improved after cytoreductive nephrectomy. The patient continued immunotherapy post-operatively and regained normalized hepatic function. To our knowledge, this is the first case reporting use of systemic immunotherapy with surgery in Stauffer's syndrome, and we provide clinical insight into a treatment regimen which may be employed in future cases.
Exploring the Scope of a Novel Ligand Class: Synthesis and Catalytic Examination of Metal Complexes with ‘Normal’ 1,2,3-Triazolylidene Ligands (2013)

Using new 'normal'-substituted 1,2,3-triazolylidene silver compounds as starting materials allowed for preparation of a series of molybdenum, ruthenium, rhodium, and palladium transition metal complexes bound to the new 1,2,3-triazolylidene ligand system. In this work, the first triazolylidene Mo compound is presented as well as the first structural investigation of a silver complex with a monodentate 1,2,3-triazolylidene. Furthermore, the triazolylidene Pd complex and the Mo complex were tested as precatalysts in Suzuki-Miyaura coupling and epoxidation catalysis, respectively.