gebhart/patrepeval huggingface dataset:
Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice (2021)

Susceptibility to doxorubicin-induced nephropathy (DIN), a toxic model for the induction of proteinuria in mice, is related to the single-nucleotide polymorphism (SNP) C6418T of the Prkdc gene encoding for the DNA-repair enzyme DNA-PKcs. In addition, plasminogen (Plg) has been reported to play a role in glomerular damage. Here, we investigated the interdependence of both factors for the development of DIN. Genotyping confirmed the SNP of the Prkdc gene in C57BL/6 (PrkdcC6418/C6418) and 129S1/SvImJ (PrkdcT6418/T6418) mice. Intercross of heterozygous 129SB6F1 mice led to 129SB6F2 hybrids with Mendelian inheritance of the SNP. After doxorubicin injection, only homozygous F2 mice with PrkdcT6418/T6418 developed proteinuria. Genetic deficiency of Plg (Plg-/-) in otherwise susceptible 129S1/SvImJ mice led to resistance to DIN. Immunohistochemistry revealed glomerular binding of Plg in Plg+/+ mice after doxorubicin injection involving histone H2B as Plg receptor. In doxorubicin-resistant C57BL/6 mice, Plg binding was absent. In conclusion, susceptibility to DIN in 129S1/SvImJ mice is determined by a hierarchical two-hit process requiring the C6418T SNP in the Prkdc gene and subsequent glomerular binding of Plg. This article has an associated First Person interview with the first author of the paper.
A new cleaning technique for x-ray masks in alkaline solutions by control of surface potential (2002)

This paper presents an electrochemical surface cleaning (ECSC) technique for x-ray masks employing amorphous WN/sub x/ absorbers. The electrostatic surface potential of the mask in alkaline solutions is precisely controlled for preventing from corrosion or etching of absorber films during cleaning, thus leading to almost no change in pattern dimension and film stress between before and after cleaning.
Direct Analysis of Reversed-Phase High-Performance Thin Layer Chromatography Separated Tryptic Protein Digests Using a Liquid Microjunction Surface Sampling Probe/Electrospray Ionization Mass Spectrometry System (2010)

The sampling, ionization and detection of tryptic peptides separated in one-dimension on reversed-phase high-performance thin layer chromatography (HPTLC) plates was performed using liquid microjunction surface sampling probe electrospray ionization mass spectrometry. Tryptic digests of five proteins [cytochrome c, myoglobin, beta-casein, lysozyme and bovine serum albumin (BSA)] were spotted on reversed phase HPTLC RP-8 F254s and HPTLC RP-18 F254s plates. The plates were then developed using 70/30 methanol/water with 0.1 M ammonium acetate. A dual purpose extraction/electrospray solution containing 70/30/0.1 water/methanol/formic acid was infused through the sampling probe during analysis of the developed lanes. Both full scan mass spectra and data dependent tandem mass spectra were acquired for each development lane to detect and verify the peptide distributions. Data dependent tandem mass spectra provided both protein identification and sequence coverage information. Highest sequence coverages were achieved for cytochrome c and myoglobin (62.5% and 58.3%, respectively) on reversed phase RP-8 plates. While the tryptic peptides were separated enough for identification, the peptide bands did show some overlap with most peptides located in the lower half of the development lane. Proteins whose peptides were more separated gave higher sequence coverage. Larger proteins such as beta-casein and BSA which were spotted in lower relative amounts gave much lower sequence coverage than the smaller proteins.
Speller performance prediction for query autocorrection (2013)

Query speller is an indispensable part of any modern search engine. In this paper we define the problem of speller performance prediction and apply it to the task of query spelling autocorrection. As candidates for query autocorrection we used the suggestions generated by a query speller. To determine their reliability we used a binary classifier trained on manually labeled data. In addition to the basic standard lexical and statistical features we utilized a number of new click-based features, what allowed to significantly outperform the algorithm trained on the basic set of features.
A theory of specular surface geometry (2002)

A theoretical framework is introduced for the perception of specular surface geometry. When an observer moves in three-dimensional space, real scene features, such as surface markings, remain stationary with respect to the surfaces they belong to. In contrast, a virtual feature, which is the specular reflection of a real feature, travels on the surface. Based on the notion of caustics, a novel feature classification algorithm is developed that distinguishes real and virtual features from their image trajectories that result from observer motion. Next, using support functions of curves, a closed-form relation is derived between the image trajectory of a virtual feature and the geometry of the specular surface it travels on. It is shown that in the 2D case where camera motion and the surface profile are coplanar, the profile is uniquely recovered by tracking just two unknown virtual features. Finally, these results are generalized to the case of arbitrary 3D surface profiles that are travelled by virtual features when camera motion is not confined to a plane. An algorithm is developed that uniquely recovers 3D surface profiles using a single virtual feature tracked from the occluding boundary of the object. All theoretical derivations and proposed algorithms are substantiated by experiments.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Laser-Assisted Machining of Reaction Sintered Mullite Ceramics (2001)

Abstract The present study focuses on the evaluation of the laser-assisted machining (LAM) of pressureless sintered mullite ceramics. Due to mullite’s low thermal diffusivity and tensile strength, a new method for applying laser power is devised to eliminate cracking and fracture of the workpiece during laser heating. The LAM process is characterized by means of cutting force and surface temperature measurements for a variety of operating conditions. Estimated material removal temperatures and the ratio of the feed force to the main cutting force are used to determine material removal mechanisms and regimes for brittle fracture and semi-continuous and continuous chip formation. Surface roughness and subsurface damage are compared for typical parts produced by LAM and grinding. Tool wear characteristics are investigated for variations in laser power, and hence material removal temperature, during LAM of mullite with carbide tools.
Vitamin D levels do not predict the stage of hepatic fibrosis in patients with non-alcoholic fatty liver disease: A PRISMA compliant systematic review and meta-analysis of pooled data (2018)

Low vitamin D status is not associated with higher stages of liver fibrosis in patients with NAFLD.
Automatic Variance Analysis of Multistage Care Pathways (2014)

A care pathway (CP) is a standardized process that consists of multiple care stages, clinical activities and their relations, aimed at ensuring and enhancing the quality of care. However, actual care may deviate from the planned CP, and analysis of these deviations can help clinicians refine the CP and reduce medical errors. In this paper, we propose a CP variance analysis method to automatically identify the deviations between actual patient traces in electronic medical records (EMR) and a multistage CP. As the care stage information is usually unavailable in EMR, we first align every trace with the CP using a hidden Markov model. From the aligned traces, we report three types of deviations for every care stage: additional activities, absent activities and violated constraints, which are identified by using the techniques of temporal logic and binomial tests. The method has been applied to a CP for the management of congestive heart failure and real world EMR, providing meaningful evidence for the further improvement of care quality.
Developments in active control of aircraft interior noise—Directions for tonal and broadband noise sources (1999)

Aircraft interior noise is a continuing problem for a wide range of aircraft types. Interior noise levels in general aviation aircraft make communication difficult, significantly impact pilot endurance, and are considered important to the reemergence of this class of aircraft. For passengers in propeller-powered commuter aircraft, conversation is difficult at best and becomes oppressive on the passengers for long periods. It is also regarded as one reason for the replacement of propeller commuter aircraft by the emerging regional jet. In business jets, the passengers are often interested in conducting meetings during flights. This calls for low SPL and SIL for which the aircraft incurs both space and weight penalties. Large commercial aircraft pay a significant weight penalty for current interior noise levels considered acceptable. With the drive for more weight-effective airframes, the challenge becomes even more difficult. This paper will show some current efforts to develop more efficient active control technologies for both tonal noise sources and broadband noise sources. These will include improvements in controller technologies, actuator implementation, optimization of transducer topology, improved coupling to the noise source, and integration of the active technology with conventional passive technology.
Determining androgen inactivation status in prostate cancer by [18F] DHT PET. (2019)

191 Background: Castration-resistant prostate cancer occurs in part due to increased tumor tissue testosterone (T) and dihydrotestosterone (DHT) that sustain tumor growth. T and DHT are converted to inactive T- and DHT-glucuronide (T/DHT-G) by uridine 5'-diphospho-glucuronosyltransferase family genes (UGT2B15 and UGT2B17) in glucuronidation-competent cells and excreted, but not in glucuronidation-deficient cells. Thus, low glucuronidation activity enables prostate tumors to preserve androgens, which increases hormone treatment resistance and may be detectable by functional imaging. Methods: We knocked out (KO) UGT2B15 and 17 in LNCaP cells and tested the DHT retention rate in the cell lines by pulse-chase using [ 3 H]DHT as a probe. Free and DHT-G retention rates were separately determined after 5 to 60 min. To increase the signal difference between control and KO cells, we screened several ATP-binding cassette transporter inhibitors to block DHT-G excretion. We performed [ 18 F]DHT PET/CT in castrated mice having a control and a KO xenograft on contralateral flanks ( n = 3). The ratio of the standard uptake value (SUV) in control to KO xenografts in each mouse was calculated. To increase the ratio between control and KO tumors, 50µg cyclosporin A (CSA) was injected 30 min before injecting [ 18 F]DHT. Results: After 5 minutes of chase, control cells retained twice the DHT of KO cells. In control cells, 50%-70% DHT was glucuronidated. Almost no DHT-G was detected in KO cells, and free DHT was similar to control. Of the inhibitors, only CSA increased DHT-G (but not free DHT) in control cells, resulting in a 3-4-fold increase in overall signal. In vivo PET/CT showed control xenografts had higher peak SUV but also a higher elution rate. CSA increased the SUV ratio by 1.5-2. Conclusions: We developed a PET/CT modality to detect androgen inactivation in a prostate cancer xenograft model. Androgen-glucuronidation-proficient tumors give off a stronger signal that is increased by ATP transporter inhibition. Our method can provide a noninvasive means of determining androgen metabolism status and therefore could possibly predict effectiveness of potential therapies in a subgroup of tumors predisposed to androgen deprivation resistance.
Structure and bonding in Group 4 metallocene acetylide and metallacyclopentadiene complexes (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and bonding in Group 4 metallocene acetylide and metallacyclopentadiene complexesEugene T. Knight, Lori K. Myers, and Mark E. ThompsonCite this: Organometallics 1992, 11, 11, 3691–3696Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/om00059a036https://doi.org/10.1021/om00059a036research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Cryopreservation of Human Wharton’s Jelly-derived Mesenchymal Stem Cells Following Controlled Rate Freezing Protocol Using Different Cryoprotectants; A Comparative Study (2015)

Although 10% DMSO has shown higher post-thaw cell viability compare to 10% PVP and cocktail solution, the present study indicates the feasibility of developing a well-defined DMSO free cryosolution which can improve storage and future broad range applications of WJMSCs in regenerative medicine without losing their basic stem cell characteristics.
Early Diagnosis and Management of Nitrogen Deficiency in Plants Utilizing Raman Spectroscopy (2020)

Nutrient deficiency alters growth and development of crop plants and compromises yield. Real-time non-invasive monitoring of the nutritional status of crops would allow timely applications of fertilizers to optimize for growth and yield at different times of the plant's life cycle. Here, we used Raman spectroscopy to characterize Arabidopsis and two varieties of leafy vegetable crops under nitrogen sufficient and deficient conditions. We showed that the 1046 cm<sup>-1</sup> Raman peak serves as a specific signature of nitrogen status <i>in planta</i>, which can be used for early diagnosis of nitrogen deficiency in plants before onset of any visible symptoms. Our research can be applied toward crop management for sustainable and precision agriculture.
Predictive Value of Inflammatory Markers for Irrigation and Debridement of Acute TKA Infection (2013)

The roles of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are well established in the diagnosis of total joint infection. However, it is not entirely clear what value preoperative CRP and ESR have in predicting outcomes following irrigation and debridement with insert exchange for acute hematogenous total knee arthroplasty infection. The total joint registry at the authors' institution was reviewed to identify all patients who underwent irrigation and debridement with insert exchange for a diagnosis of acute hematogenous infection of a primary total knee arthroplasty. Patient medical records were then reviewed for preoperative white blood cell count and CRP and ESR levels; interval from symptom onset to surgery; infecting organism; and any additional surgery for infection. Average patient age was 72 years (range, 51-91 years). Forty-four patients were men and 26 were women. Mean follow-up was 54 months (range, 12-176 months). Seventy-two procedures (69 patients) met the inclusion criteria. Of these, 20 (28%) additional procedures for infection were performed and were classified as treatment failures. Average CRP was 173.7 mg/L in the successful group and 159.0 mg/L in the failed group (P=.31). Mean ESR at the time of irrigation and debridement with insert exchange was 61.3 mm/hr in both groups (P=.49). Although CRP and ESR are well established in the diagnosis of infection, no role currently exists for them in predicting the outcomes of irrigation and debridement with insert exchange for the treatment of acute hematogenous total knee arthroplasty infection.
Is FAM19A5 an adipokine? Peripheral FAM19A5 in wild-type, FAM19A5 knockout, and LacZ knockin mice (2020)

ABSTRACT FAM19A5 is a novel secretory protein primarily expressed in the brain. However, a recent study reported that FAM19A5 is an adipocyte-derived adipokine that regulates vascular smooth muscle function through sphingosine-1-phosphate receptor 2 (S1PR2). In our study, we investigated FAM19A5 transcript and protein levels in peripheral tissues, including adipose tissues, from wild-type, FAM19A5 knockout, and FAM19A5 LacZ knockin mice. We found that FAM19A5 transcript levels in the central nervous system were much greater than those in any of the peripheral tissues, including adipose tissues. Furthermore, the FAM19A5 protein levels in adipose and reproductive tissues were below detectable limits for Western blot analysis. Additionally, we found that the FAM19A5 protein did not interact with S1PR2 in terms of G protein-mediated signal transduction, β-arrestin recruitment, or ligand-mediated internalization. Taken together, our findings revealed basal levels of FAM19A5 transcripts and proteins in peripheral tissues, confirming its primary expression in the central nervous system and lack of significant interaction with S1PR2.
Measurement and interpretation of differential cross sections for Higgs boson production at s=13TeV (2019)

Differential Higgs boson (H) production cross sections are sensitive probes for physics beyond the standard model. New physics may contribute in the gluon-gluon fusion loop, the dominant Higgs boson production mechanism at the LHC, and manifest itself through deviations from the distributions predicted by the standard model. Combined spectra for the H , H ZZ, and H bb decay channels and the inclusive Higgs boson production cross section are presented, based on proton-proton collision data recorded with the CMS detector at s = 13 TeV corresponding to an integrated luminosity of 35.9 fb -1 .
Learning to Synthesize Volumetric Meshes from Vision-based Tactile Imprints (2022)

Vision-based tactile sensors typically utilize a deformable elastomer and a camera mounted above to provide high-resolution image observations of contacts. Obtaining accurate volumetric meshes for the deformed elastomer can provide direct contact information and benefit robotic grasping and manipulation. This paper focuses on learning to synthesize the volumetric mesh of the elastomer based on the image imprints acquired from vision-based tactile sensors. Synthetic image-mesh pairs and real-world images are gathered from 3D finite element methods (FEM) and physical sensors, respectively. A graph neural network (GNN) is introduced to learn the image-to-mesh mappings with supervised learning. A self-supervised adaptation method and image augmentation techniques are proposed to transfer networks from simulation to reality, from primitive contacts to unseen contacts, and from one sensor to another. Using these learned and adapted networks, our proposed method can accurately reconstruct the deformation of the real-world tactile sensor elastomer in various domains, as indicated by the quantitative and qualitative results.
ChemInform Abstract: Phosphane Alkylenes. Part 54. Cumulated Ylides. Part 21. A New Way to N‐Substituted (Triphenylphosphoranylidene)ketenimines. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Integrated Microreactor System for Gas Phase Reactions (2007)

This chapter contains sections titled: Overview Introduction Microreactor Packaging Microreactor Packaging Hardware DieMateTM Electrical Interconnect Details DieMateTM Fluidic Interconnect Details DieMateTM Manifold Heating DieMateTM Manifold Fabrication DieMateTM Manifold Insulation Microreactor System Design System Chassis Primary Feed Gas Manifold Reactor Feed Gas Manifold Reactor Board Transport Tube Heating Temperature Controller Board Heater Driver Circuit Boards Testing Procedures System Control and Process Monitoring System Hardware Process Control Software Process Control Interface Run Time (RT) Engine tab Microreactors Tab Automation Testing Procedures Microreactor Process Safety Overview Process Hazards AIMS Safety Features Microreactor Experimental Methods Overview Experimental Protocol GC Method AIMS Testing Results and Discussion Overview AIMS vs. MARS Setups System Size Gas Flow Manifold Process Automation Electrical Wiring Reactor Failure and Replacement Redwood Microvalve Operation Redwood Mass Flow Controllers Other Process Components Automation and Hardware Evaluations Temperature Sensors Temperature Controllers Process Control Loops Reaction Performance Results Methane Oxidation Ammonia Oxidation Summary and Conclusions References
Impact of the New Kidney Allocation System on Perioperative Outcomes and Costs in Kidney Transplantation (2017)

Policy changes in organ allocation can have a significant impact on perioperative costs and outcomes, which can have a downstream influence on transplantation center perisurgical care processes.
Can the Response to Eradication Therapy in Helicobacter pylori Infection be Predicted? (2003)

The failure to eradicate Helicobacter pylori infection with antibiotic therapy has become a major clinical problem, not entirely accounted for by either poor compliance or antibiotic resistance. Recognition that failed eradication is one outcome of the host-parasite relationship focuses attention on impaired host protection as a determinant of nonresponse to antibiotics. A secreted interleukin (IL)-4 whole blood assay was developed to determine whether persistent infection was contributed to by impaired cytokine responses. The blood assay was shown to correlate well with mucosal organ cultures. Significantly lower levels of IL-4 were detected in the whole blood assays in 11 subjects with failed eradication compared with subjects with successful eradication (P<0.05). This latter group underwent a Th1 to Th0 "switch", which appears to be important to successful eradication. Detection of subjects at risk for failing to eradicate infection with standard combination therapy, by virtue of low secreted IL-4 in whole blood cultures, may have clinical value.
ChemInform Abstract: The First and Efficient Synthesis of 7‐Aryl‐6‐methoxycarbonylquinazolines via Unexpected Reaction of 6‐Arylethynylpyrimidine‐5‐carbaldehydes and Methyl Mercaptoacetate. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.