gebhart/patrepeval huggingface dataset:
Identification of multiple proteoforms biomarkers on clinical samples by routine Top-Down approaches (2018)

Top-Down approaches have an extremely high biological relevance, especially when it comes to biomarker discovery, but the necessary pre-fractionation constraints are not easily compatible with the robustness requirements and the size of clinical sample cohorts. We have demonstrated that intact protein profiling studies could be run on UHR-Q-ToF with limited pre-fractionation (Schmit et al., 2017) [1]. The dataset presented herein is an extension of this research. Proteoforms known to play a role in the pathophysiology process of Alzheimer's disease were identified as candidate biomarkers. In this article, mass spectrometry performance of these candidates are demonstrated.
Correction: Genetics, Receptor Binding Property, and Transmissibility in Mammals of Naturally Isolated H9N2 Avian Influenza Viruses (2020)

There is an error in Fig 3 . The genotype number of DK/ZJ/
Electronic Structures of Nitridomanganese(V) Complexes (1998)

The single-crystal polarized absorption and circular dichroism spectra of the nitridomanganese(V) complexes (salen)Mn⋮N (1), (1S,2S-(−)-saldpen)Mn⋮N (2), and (1R,2R-(+)-saldpen)Mn⋮N (3) have been measured [salen = N,N‘-ethylenebis(salicylideneaminato) dianion, 1S,2S-(−)-saldpen = N,N‘-(1S,2S-(−)-diphenyl)ethylenebis(salicylideneaminato) dianion, and 1R,2R-(+)-saldpen = N,N‘-(1R,2R-(+)-diphenyl)ethylenebis(salicylideneaminato) dianion]. As revealed by X-ray crystal structure analyses, these molecules have a distorted square-pyramidal geometry with a short Mn⋮N bond distance (1.52(3) Å for 2). The Cs compounds have a low-spin 1A‘[a‘(x2 − y2)]2 ground state. The lowest absorption system (∼600 nm) consists of two components that are separated by approximately 4000 cm-1; these are assigned to 1A‘ → 1A‘[a‘(x2 − y2)a‘(yz)] (14 900 cm-1) and 1A‘ → 1A‘‘[a‘(x2 − y2)a‘‘(xz)] (18 900 cm-1) transitions.
TU‐C‐AUD C‐04: Custom Built Small Animal IGRT Platform (2008)

Over the past 2 decades, there has been a widening technological disparity between laboratory radiation research and clinical radiation therapy. Whereas simple single beam/single fraction techniques are commonly used to irradiate laboratory animals, advanced three‐dimensional (3D) and computer‐controlled delivery technologies are now used clinically to pinpoint fractionated conformal radiation therapy (CRT) and intensity modulated radiation therapy (IMRT). The technological disparity presents a difficult hurdle in the development of novel treatment methods that combine conformal irradiation and other therapeutic agents. There is clearly a pressing need to bridge the technological gap between laboratory radiation research and human treatment methods. To that end, we have constructed a Small Animal Radiation Research Platform (SARRP) which integrates imaging, radiation delivery and treatment planning capabilities. The SARRP spans 3 ft × 4 ft × 6 ft (W×L×H). A dual‐focal (0.4 mm and 3.0 mm) spot, constant voltage x‐ray source is mounted on isocentric gantry. The source to isocenter distance is 35 cm. Eighty to 100 kVp x‐rays from the smaller focal spot are used for imaging. Both focal spots operate at 225 kVp for irradiation. Robotic translate/rotate stages are used to position the animal. A novel configuration is devised for CBCT imaging by rotating the horizontal animal between the x‐ray source and a flat panel amorphous silicon detector that are fixed at opposite horizontal positions of 90° and 270° respectively. Radiation beams ranging from 0.5 mm in diameter to (60 × 60) mm 2 are available. Conformal dose distributions are delivered using a combination of gantry and robotic stage motion. Treatment planning is performed at sub‐mm resolution where Monte Carlo dose calculations are coupled to a research Pinnacle system for visualization. Depending on filtration, the isocenter dose outputs at 1 cm depth in water range from 22 to 375 cGy/min from the smallest to the largest radiation fields. The 20% to 80% dose fall‐off spans 0.16 mm. CBCT with (0.55 × 0.55 × 0.55) mm 3 voxel resolution is acquired with less than 1 cGy in 4 min. The ability of our system to focally irradiate a specific anatomic region or target in a mouse subject has generated exciting new collaborations between laboratory and translational research. These include the study of the response of normal tissue and tumor to focal radiation injuries; the development of molecular imaging markers for early assessment of radiation induced toxicity in the lungs; and the study of molecularly targeted therapy in combination with radiation. We are hopeful that our SARRP, and other similar initiatives, will serve to provide the timely and powerful technology to greatly transform future cancer treatment. Educational Objectives: 1. Appreciate the disparity between animal radiation research methods and clinical treatment. 2. Understand the challenges in down‐sizing human treatment methods for small animal.
Figure S1 from The PET-Tracer <sup>89</sup>Zr-Df-IAB22M2C Enables Monitoring of Intratumoral CD8 T-cell Infiltrates in Tumor-Bearing Humanized Mice after T-cell Bispecific Antibody Treatment (2023)

&lt;p&gt;Figure S1 shows the in vitro tumor cell lysis mediated by CEA-TCB and CEA-4-1BBL) or FOLR1-TCB ni presence of the CD8 Mb IAB22M2C.&lt;/p&gt;
A 3D particle focusing device based on tightly curving 3D microchannels (2017)

Particle focusing is an important functionality useful in a wide set of biological applications. Nevertheless, it is still challenging to realize it in microfluidics, especially in a low pressure system, because of the intrinsic 2D nature of standard microfluidic devices; long channels or complicated device geometries with several lateral channels are usually needed to avoid this limitation. In this work we present the fabrication and optimization of a compact microfluidic chip, which is capable to perform 3D particle focusing at high flow rates, thanks to the superposition of inertial focusing and intense Dean flow in tightly curving 3D channels. The device layout comprises alternating helices and straight channel sections permitting particle focusing with driving pressures &lt; 1 bar due to the compactness of this chip. Beads characterization is performed, demonstrating the possibility of the chip to effectively focus 15 &mu;m size sample using a single inlet and with no need of additional lateral channels that could complicate the sample processing procedure. Femtosecond laser micromachining followed by chemical etching is used to fabricate the device. This technique is a two-step process that permits fabrication of 3D structures in fused silica substrates and it is a fundamental tool to obtain 3D helices in the substrate. A surface fabrication approach has been used to avoid tapered channels. We envisage the use of this chip for high speed flow cytometer applications.
Natural Products of Filamentous Fungi: Enzymes, Genes, and Their Regulation (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Polyoxometalate‐coupled Graphene via Polymeric Ionic Liquid Linker for Supercapacitors (2014)

The integration of electrical double‐layer capacitive and pseudocapacitive materials into novel hybrid materials is crucial to realize supercapacitors with high energy and power densities. Here, high levels of energy and power densities are demonstrated in supercapacitors based on a new type of nanohybrid electrode consisting of polyoxometalate (POM)‐coupled graphene in which a polymeric ionic liquid (henceforth simply PIL) serves as an interfacial linker. The adoption of PIL in the construction of nanohybrids enables a uniform distribution of discrete POM molecules along with a large surface area of graphene sheets. When testing electrochemical characteristics under a two‐electrode system, as‐prepared supercapacitors exhibit a high specific capacitance (408 F g −1 at 0.5 A g −1 ), rapid rate capability (92% retention at 10 A g −1 ), a long cycling life (98% retention during 2000 cycles), and high energy (56 Wh kg −1 ) and power (52 kW kg −1 ) densities. First‐principles calculations and impedance spectroscopy analysis reveal that the PILs enhance the redox reactions of POMs by providing efficient ion transfer channels and facilitating the charge transfer in the nanohybrids.
Capacity of the Gaussian Two-Pair Two-Way Relay Channel to Within $\frac{1}{2}$ Bit (2019)

This paper studies the transceiver design of the Gaussian two-pair two-way relay channel (TWRC), where two pairs of users exchange information through a common relay in a pairwise manner. Our main contribution is to show that the capacity of the Gaussian two-pair TWRC is achievable to within <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\frac{1}{ 2}$ </tex-math></inline-formula> bit for arbitrary channel conditions. For the outer bound, we derive a genie-aided bound of the Gaussian two-pair TWRC, which is tighter than the cut-set bound. For the inner bound, we develop a hybrid coding scheme involving Gaussian random coding, nested lattice coding, superposition coding, and network-coded decoding. We further present a message-reassembling strategy to decouple the coding design for the user-to-relay and relay-to-user links, so as to provide flexibility to fully exploit the channel randomness. We show that judicious power allocation at the users and at the relay is necessary to approach the channel capacity under various channel conditions.
Three-dimensional photoacoustic computed tomography for preclinical research and clinical translation (2021)

We introduce a three-dimensional photoacoustic computed tomography (3D-PACT) system with unparalleled imaging depth, clarity, and speed, and demonstrate that the imaged structural and functional optical contrast provide a unique tool for preclinical research and an appealing prototype for clinical translation. 3D-PACT allows for multipurpose imaging of biological tissues ranging from the rodent brain to the human breast. In the rat brain, we visualized whole brain vasculatures, oxygenation dynamics, intrinsic functional connectivity, and electrical-stimulation-induced hemodynamics. In the human breast, an in vivo imaging depth of 4 cm has been achieved by scanning the breast within a single breath hold of 10 seconds. 3D-PACT holds a high reliability to reproducibly generate detailed images with a contrast similar to that provided by contrast enhanced magnetic resonance imaging, yet with higher spatiotemporal resolution and without using exogenous contrast agents.
A communication gateway for infrastructure-independent 4G wireless access (2002)

Wireless communication infrastructure is characterized by an increasing multitude of heterogeneous systems. At the same time, service provider models are established and services designed to span physical networks irrespective of the access method used. To provide an infrastructure-independent access to services and applications for highly mobile users (e.g., in cars), we present a communication gateway architecture as an important component of fourth generation wireless communication systems. We especially emphasize the role of digital broadcast networks for future mobile networking.
The Sacro-femoral-pubic Angle Is Unreliable to Estimate Pelvic Tilt: A Meta-analysis (2023)

Level III, diagnostic study.
Simulating challenging correlated molecules and materials on the Sycamore quantum processor (2022)

Simulating complex molecules and materials is an anticipated application of quantum devices. With strong quantum advantage demonstrated in artificial tasks, we examine how such advantage translates into modeling physical problems of correlated electronic structure. We simulate static and dynamical electronic structure on a superconducting quantum processor derived from Google's Sycamore architecture for two representative correlated electron problems: the nitrogenase iron-sulfur molecular clusters, and $α$-ruthenium trichloride, a proximate spin-liquid material. To do so, we simplify the electronic structure into low-energy spin models that fit on the device. With extensive error mitigation and assistance from classically simulated data, we achieve quantitatively meaningful results deploying about 1/5 of the gate resources used in artificial quantum advantage experiments on a similar architecture. This increases to over 1/2 of the gate resources when choosing a model that suits the hardware. Our work serves to convert artificial measures of quantum advantage into a physically relevant setting.
A pure single-walled carbon nanotube thin film based three-terminal microelectromechanical switch (2011)

The electrical and physical properties of pure single-walled carbon nanotube thin films deposited through a layer-by-layer-self-assembly process are discussed. The film thickness was proportional to the number of dipping cycles. The film resistivity was estimated as 2.19×10−3 Ω cm after thermal treatment processes were performed. The estimated specific contact resistance to gold electrodes was 6.33×10−9 Ω m2 from contact chain measurements. The fabricated three-terminal microelectromechanical switch using these films functioned as a beam for multiple switching cycles with a 4.5 V pull-in voltage. This switch is believed to be a promising device for low power digital logic applications.
Probing the role of magnetic fields in star-forming filaments: NIKA2-Pol commissioning results toward OMC-1 (2022)

Dust polarization observations are a powerful, practical tool to probe the geometry (and to some extent, the strength) of magnetic fields in starforming regions. In particular, Planck polarization data have revealed the importance of magnetic fields on large scales in molecular clouds. However, due to insufficient resolution, Planck observations are unable to constrain the B-field geometry on prestellar and protostellar scales. The high angular resolution of 11.7 arcsec provided by NIKA2-Pol 1.15 mm polarimetric imaging, corresponding to 0.02 pc at the distance of the Orion molecular cloud (OMC), makes it possible to advance our understanding of the B-field morphology in star-forming filaments and dense cores (IRAM 30m large program B-FUN). The commissioning of the NIKA2-Pol instrument has led to several challenging issues, in particular, the instrumental polarization or intensity-to-polarization “leakage” effect. In the present paper, we illustrate how this effect can be corrected for, leading to reliable exploitable data in a structured, extended source such as OMC-1. We present a statistical comparison between NIKA2-Pol and SCUBA2-Pol2 results in the OMC-1 region. We also present tentative evidence of local pinching of the B-field lines near Orion-KL, in the form of a new small-scale hourglass pattern, in addition to the larger-scale hourglass already seen by other instruments such as Pol2.
Voice Prosthesis Implantable UHF RFID Self-Sensing Tag for Microbial Growth Detection (2019)

Passive Radio Frequency Identification (RFID) implantable antennas experience low efficiency due to the capacitive loading of human tissue that the implantable design has to overcome. Here we present a passive UHF implantable device able to produce a read range of 65 cm (EU frequency band) and 80 cm (US frequency band) from within the body. With a slight adjustment, this self-sensing tag can be utilized to sense microbial growth within the body once mounted upon a voice prosthesis. Simulated Candida albicans biofilm growth can be detected within the body with this sensor from early and up to a mature biofilm thickness of 30 μm (0 to 48-hour growth in vitro equivalent); allowing for detection before any infection symptoms within a patient become apparent (as early as 4-hour biofilm colonization (5 μm thickness)) and before the voice prosthesis experiences failure. This passive UHF device would permit cost-effective immediate medical intervention before any serious consequence could occur to a voice prosthesis patient.
A Convenient Synthesis of Azafulleroid of Erythronate as a New Chiral Building Block (1998)

Abstract Azafulleroid of erythronate 3 as a chiral building block was synthesized conveniently in thermal condition from the reaction of fullerene with azidoerythronate 2.
DialoGLUE: A Natural Language Understanding Benchmark for Task-Oriented Dialogue (2020)

A long-standing goal of task-oriented dialogue research is the ability to flexibly adapt dialogue models to new domains. To progress research in this direction, we introduce DialoGLUE (Dialogue Language Understanding Evaluation), a public benchmark consisting of 7 task-oriented dialogue datasets covering 4 distinct natural language understanding tasks, designed to encourage dialogue research in representation-based transfer, domain adaptation, and sample-efficient task learning. We release several strong baseline models, demonstrating performance improvements over a vanilla BERT architecture and state-of-the-art results on 5 out of 7 tasks, by pre-training on a large open-domain dialogue corpus and task-adaptive self-supervised training. Through the DialoGLUE benchmark, the baseline methods, and our evaluation scripts, we hope to facilitate progress towards the goal of developing more general task-oriented dialogue models.
Design of a 5-kW, 1-U, 10-kW/dm$^{\hbox{3}}$ Resonant DC–DC Converter for Telecom Applications (2009)

The demand for decreasing cost and volume and also for increasing efficiency leads to a constantly increasing power density of converter systems. For maximizing the power density of a 5 kW telecom supply, an optimization procedure that automatically balances the switching frequency, semiconductor and passive losses, and thermal performance has been developed. This procedure and the belonging analytical converter and transformer models are presented in this paper. Moreover, the resulting optimized design, which has a power density of 10 kW/dm 3 and an efficiency of 94.5% at a height of 1 U, is presented.
Discovery of Anthelmintic Drug Targets and Drugs Using Chokepoints in Nematode Metabolic Pathways (2013)

Parasitic roundworm infections plague more than 2 billion people (1/3 of humanity) and cause drastic losses in crops and livestock. New anthelmintic drugs are urgently needed as new drug resistance and environmental concerns arise. A "chokepoint reaction" is defined as a reaction that either consumes a unique substrate or produces a unique product. A chokepoint analysis provides a systematic method of identifying novel potential drug targets. Chokepoint enzymes were identified in the genomes of 10 nematode species, and the intersection and union of all chokepoint enzymes were found. By studying and experimentally testing available compounds known to target proteins orthologous to nematode chokepoint proteins in public databases, this study uncovers features of chokepoints that make them successful drug targets. Chemogenomic screening was performed on drug-like compounds from public drug databases to find existing compounds that target homologs of nematode chokepoints. The compounds were prioritized based on chemical properties frequently found in successful drugs and were experimentally tested using Caenorhabditis elegans. Several drugs that are already known anthelmintic drugs and novel candidate targets were identified. Seven of the compounds were tested in Caenorhabditis elegans and three yielded a detrimental phenotype. One of these three drug-like compounds, Perhexiline, also yielded a deleterious effect in Haemonchus contortus and Onchocerca lienalis, two nematodes with divergent forms of parasitism. Perhexiline, known to affect the fatty acid oxidation pathway in mammals, caused a reduction in oxygen consumption rates in C. elegans and genome-wide gene expression profiles provided an additional confirmation of its mode of action. Computational modeling of Perhexiline and its target provided structural insights regarding its binding mode and specificity. Our lists of prioritized drug targets and drug-like compounds have potential to expedite the discovery of new anthelmintic drugs with broad-spectrum efficacy.
Atomic layer deposition (ALD) technology for reliable RF MEMS (2003)

A nano-layer inorganic coating technology has been developed to protect RF MEMS from electrical shorting as well as long-term reliability failures due to charging or moisture. The combination of alumina dielectric and zinc-oxide conducting layers can be constructed one atomic layer at a time. At 177/spl deg/C, the released RF MEMS devices can be coated on a wafer or as a single device with conformal, inorganic coverage where the thickness and electrical conductivity can be controlled to meet desired values. With additional chemical treatment, the surface could be made hydrophobic to avoid moisture-induced stiction. The long-term reliability problem is the main barrier that impedes the growth of RF MEMS applications. This novel atomic layer deposition (ALD) technology can help in overcoming this limitation.
Ionospheric turbulent parameter inversion using scintillation log-amplitude spectra: performance and results (2019)

International audience
Nitrogen-15 Fractionation by Countercurrent Exchange between Liquid N2O3-N2O4Mixtures and Their Vapor Phases under Pressured Conditions (1985)

Abstract The nitrogen isotope exchange system for 15N-fractionation consisting of liquid mixtures of N2O3 and N2O4 and the vapor phase in equilibrium with the liquid (NO/N2O3 system) has been studied at temperatures between −9 and 20°C under various pressures below 4 atm. A countercurrent isotope exchange apparatus and an associated product refluxer system are described. At 15°C the effective separation factor, αeff, increases from 1.006 at 1 atm to 1.030 at 2.7 atm and levels off thereafter. The observed αeff values are in good agreement with recent spectroscopic data. The height equivalent of theoretical plate (HETP) correlates well with the linear flow rate of gas phase, showing a dominant diffusion-control of the overall exchange rate. At 15°C the HETP of the NO/N2O3 system under 3∼4 atm can be smaller by factors of 7 to 10 than that of the Nitrox (NO/HNO3 exchange) system having the same product rate, rendering the former system a possibility for significantly smaller plant volume.
Portable 1.55&#x03BC;m terahertz spectrometer and imaging system (2012)

We demonstrate a portable terahertz (THz) spectrometer and imaging system. Absorption lines of water vapor in the free space are clearly observed by using the THz system. A THz imaging of a medical knife behind a poly-ethylene is finely measured by the same THz system as well.