gebhart/patrepeval huggingface dataset:
β 1 -Adrenergic Receptor Blockade Attenuates Angiotensin II–Mediated Catecholamine Release Into the Cardiac Interstitium in Mitral Regurgitation (2003)

beta1-RB decreases renin-angiotensin system sympathostimulation and activation by attenuating the Ang II-mediated NE and Epi release into the cardiac ISF and circulation and by decreasing left ventricular angiotensin-converting enzyme expression in the early phases of volume overload.
Contribution of Secretory Antibodies to Intestinal Mucosal Immunity against Helicobacter pylori (2013)

The natural immune response to Helicobacter pylori neither clears infection nor prevents reinfection. However, the ability of secretory antibodies to influence the course of H. pylori infection has not been determined. We compared the natural progression of H. pylori infection in wild-type C57BL/6 mice with that in mice lacking the polymeric immunoglobulin receptor (pIgR) that is essential for the secretion of polymeric antibody across mucosal surfaces. H. pylori SS1-infected wild-type and pIgR knockout (KO) mice were sampled longitudinally for gastrointestinal bacterial load, antibody response, and histological changes. The gastric bacterial loads of wild-type and pIgR KO mice remained constant and comparable at up to 3 months postinfection (mpi) despite SS1-reactive secretory IgA in the intestinal contents of wild-type mice at that time. Conversely, abundant duodenal colonization of pIgR KO animals contrasted with the near-total eradication of H. pylori from the intestine of wild-type animals by 3 mpi. H. pylori was cultured only from the duodenum of those animals in which colonization in the distal gastric antrum was of sufficient density for immunohistological detection. By 6 mpi, the gastric load of H. pylori in wild-type mice was significantly lower than in pIgR KO animals. While there was no corresponding difference between the two mouse strains in gastric pathology results at 6 mpi, reductions in gastric bacterial load correlated with increased gastric inflammation together with an intestinal secretory antibody response in wild-type mice. Together, these results suggest that naturally produced secretory antibodies can modulate the progress of H. pylori infection, particularly in the duodenum.
The NIR-sensitized cationic photopolymerization of oxetanes in combination with epoxide and acrylate monomers (2021)

NIR-sensitized photopolymerisation at 805 nm facilitates the cationic polymerization of oxetanes. This can additionally be combined with free-radical polymerization.
Supplementary Material and Methods from EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor (2023)

&lt;p&gt;This file contains additional Materials and Methods that are not listed in the main text.&lt;/p&gt;
Supplementary Figure 1 from Mechanisms of Activity of the TORC1 Inhibitor Everolimus in Waldenstrom Macroglobulinemia (2023)

&lt;p&gt;PDF file - 32K, Everolimus targets mTOR-down stream targets in WM patients. Bone marrow specimens have been stained for phosphor(p)-S6R and p-4EBP1. Signal quantification for each target has been obtained from 4 different areas, on matched pre- and post-everolimus treatment of 4 patients presenting with partial response; and on matched pre- and post-everolimus treatment of 3 patients presenting with stable disease. Number of positive cells has been obtained on 4 different fields of the bone marrow biopsy, and average and standard deviation provided. P indicates P values; N.S.: not significant.&lt;/p&gt;
Design and implementation of a dual-mode ultrasound array driver. (2011)

University of Minnesota M.S. thesis. November 2011. Major: Electrical engineering. Advisor: Emad S Ebbini. 1 computer file (PDF); viii, 61 pages.
In Vitro Growth of Murine T Cells (1978)

Abstract Growth factors (GM), produced by murine lymphoid cells incubated with Concanavalin A, have been used to grow cytotoxic lymphoid cells in culture. C57BL/6 and DBA/2 lymphoid cells were sensitized against each other in primary, secondary, and tertiary in vitro cultures. These sensitized cells were grown in vitro in GM and retained their cytotoxic properties. Cells grew in culture about 10-fold every 5 to 7 days for over 2 months. Initial growth of cytotoxic cells in GM resulted in marked enhancement of specific cytotoxicity that returned to original levels after subsequent subcultures. After five 10-fold cell culture generations some nonspecific cytotoxicity directed against the responding target cell strain appeared in continuous cultures. This technique for growing large numbers of cytotoxic cells may be of value in the development of adoptive immunotherapies.
Feasibility of Single‐Stage Laparoscopic Resection After Placement of a Self‐Expandable Metallic Stent for Obstructive Left Colorectal Cancer (2008)

A single-stage operation consisting of SEMS placement followed by laparoscopic surgery seems to be a feasible and safe treatment option for obstructive left colorectal cancer.
Capacity definitions and coding strategies for general channels with receiver side information (2002)

We consider three capacity definitions for a channel with channel side information at the receiver. The capacity is the highest rate asymptotically achievable. The outage capacity is the highest rate asymptotically achievable with a given probability of decoder-recognized outage. The expected capacity is the highest expected rate asymptotically achievable using a single encoder and multiple decoders, where side information at the decoder determines which code to use. We motivate the latter definitions using the concept of maximizing reliably received rate. A coding theorem is given for each capacity.
THE SYNTHESIS OF SUCCINIC ACIDS AND DERIVATIVES. A REVIEW (2002)

(2002). THE SYNTHESIS OF SUCCINIC ACIDS AND DERIVATIVES. A REVIEW. Organic Preparations and Procedures International: Vol. 34, No. 4, pp. 337-366.
Selection of oligonucleotide probes for protein coding sequences (2003)

The oligo design program OligoPicker and its source code are freely available at our website.
The effect of different microwave powers and frequencies in the reduction of magnetite to iron (2022)

This presentation discusses the results for a study on the reduction of magnetite to iron by evaluating the effect of applied power and frequency.
Unraveling Tissue Metabolism using Endogenous, Two-photon Imaging: Mechanisms and Diagnostic Biomarkers (2016)

Changes in optical metabolic signals related to the intensity, lifetime and spatial localization of endogenous fluorescence are associated with alterations in specific biosynthetic and bioenergetic cellular pathways, which can serve as diagnostic and therapeutic targets.
Supplementary Table S5 from Anagrelide for Gastrointestinal Stromal Tumor (2023)

&lt;p&gt;Supplementary Table S5. List of genes most affected by anagrelide treatment and protein expression data.&lt;/p&gt;
A Micro-Coordinate Measurement Machine (CMM) for Large-Scale Dimensional Measurement of Micro-Slits (2016)

This paper presents a micro-coordinate measuring machine (micro-CMM) for large-scale dimensional measurement of a micro-slit on a precision die coater by using a shear-mode micro-probe. A glass micro sphere with a nominal diameter of 52.3 μm was attached on one end of a tapered glass capillary tube as a probe tip ball. The micro-slit width of a slot die coater with a nominal slit width of 85 μm was measured by the micro-CMM. The probe tip was placed in the slit for the measurement. The effective working length of the probe was confirmed experimentally to be at least 1 mm. In order to measure the gap width uniformity over the entire slot die length of 200 mm, an air-bearing linear slide with a travelling stroke of 300 mm was employed in the micro-CMM to position the probe along the length direction of the slot die. The angular alignment error and the motion error of the air-bearing linear slide as well as those of the stages for positioning the probe along the direction perpendicular to the length direction of the slot die were investigated for evaluation of the expanded uncertainty of gap width measurement.
Meibomian gland dysfunction and contact lens intolerance. (1980)

A study of a syndrome characterized by deficient or inadequate Meibomian gland secretions, minimal or transient symptoms suggestive of ocular dryness, fluorescein staining of the cornea (often detected only after delayed observation or sequential instillation of stain), and contact lens intolerance is described. Clinical and cytologic studies indicate that the syndrome is due to obstruction of the Meibomian gland orifices by desquamated epithelial cells that tend to aggregate in keratotic clusters, which results in alteration of the Meibomian glands' contribution to the precorneal tear film. Further complication may result from bacterial proliferation in the desquamated keratotic cells and the release of the bacteria and their toxic products into the precorneal tear film from these reservoirs in the excretory pathways of the Meibomian glands.
Discontinuous Transmission detection of signals carrying unknown data (2014)

This paper proposes a Discontinuous Transmission (DTX) hybrid detection algorithm for signals with sequences transmitted from a given subset. The method is applied to the E-DPCCH channel of UMTS HSUPA. Performance simulations are made using realistic scenarios and show that the proposed method achieves high accuracy, while maintaining a low average computational complexity.
Association of Phosphorylation Reactions with the Glucocorticoid Receptor (2018)

Numerous membrane receptors for hormones and growth factors have been demonstrated to function as protein kinases (PKs), and phosphorylation of these receptors, proteins themselves, plays a key role in regulating the enzymatic activity. In this chapter, the authors review the evidence that suggests that phosphorylation/dephosphorylation reactions play a key role in regulating glucocorticoid-receptor activity. They focus on more recent data that suggest that the purified, activated/transformed glucocorticoid receptor either is itself a PK or is very closely associated with a distinct PK. The various experimental conditions required for maximal receptor-mediated kinase activity (autophosphorylation, histone phosphorylation, and nuclear matrix phosphorylation), as well as the biochemical reagents that have been utilized to probe the structure of the kinase, are also discussed. However, the activity of histone phosphorylation leads to speculation that glucocorticoid receptor-mediated phosphorylation of nuclear proteins may be a component of gene activation.
PKC-ε Is Required for Mechano-sensitive Activation of ERK1/2 in Endothelial Cells (1997)

Mechano-sensitive regulation of endothelial cells (EC) function by shear stress is critical for flow-induced vasodilation and gene expression. Previous studies by our laboratory demonstrated that shear stress activates the 44- and 42-kDa extracellular signal-regulated kinases (ERK1/2) in EC in a time- and force-dependent manner. ERK1/2 activation was inhibited by protein kinase C (PKC) down-regulation with phorbol 12,13-dibutyrate (1 microM for 24 h) but not by calcium chelation with BAPTA-AM (acetoxymethyl ester of BAPTA) (75 microM for 30 min), suggesting that a novel PKC isoform (delta, epsilon, eta, theta) mediates shear stress-induced ERK1/2 activation. Western blotting with PKC isoform-specific antibodies demonstrated expression of PKC-alpha, -epsilon, and -zeta isoforms in EC. PKC-epsilon was specifically inhibited by transfection with antisense PKC-epsilon phosphorothioate oligonucleotides (1,000 nM for 6 h). Antisense treatment decreased PKC-epsilon protein levels by 80 +/- 13% after 72 h and completely inhibited shear stress-stimulated ERK1/2 activation. Scrambled PKC-epsilon oligonucleotides and antisense PKC-alpha and PKC-zeta oligonucleotides had no effect on ERK1/2 activity. PKC-epsilon appeared specific for mechano-sensitive ERK1/2 activation, as antisense PKC-epsilon oligonucleotides did not inhibit ERK1/2 activation by EGF or bradykinin but did inhibit ERK1/2 activation upon EC adhesion to fibronectin. These results define a pathway for shear stress-mediated ERK1/2 activation and establish a new function for PKC-epsilon as part of a mechano-sensitive signal transduction pathway in EC.
Finding Their Data Voice: Practices and Challenges of Dashboard Users (2021)

Dashboards are the ubiquitous means of data communication within organizations.Yet we have limited understanding of how they factor into data practices in the workplace, particularly for data workers who do not self-identify as professional analysts. We focus on data workers who use dashboards as a primary interface to data, reporting on an interview study that characterizes their data practices and the accompanying barriers to seamless data interaction.While dashboards are typically designed for data consumption, our findings show that dashboard users have far more diverse needs. To capture these activities, we frame data workers’ practices as data conversations:conversations with data capture classic analysis(asking and answering data questions), while conversations through and around data involve constructing representations and narratives for sharing and communication. Dashboard users faced substantial barriers in their data conversations: their engagement with data was often intermittent, dependent on experts, and involved an awkward assembly of tools. We challenge the visualization and analytics community to embrace dashboard users as a population and design tools that blend seamlessly into their work contexts
CHARACTERIZATION OF RECOMBINANT CEA PRODUCED IN A BACULOVIRUS EXPRESSION SYSTEM (1993)

Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.
Probing the Growth and Ion Transport Properties of SEI Layers with NMR Using Novel 6Li/7Li Exchange Experiments (2017)

Detecting and observing changes in the surface electrolyte interphase (SEI) is difficult due to the small size and amorphous nature of this layer, while its reactivity calls for characterization to be performed in situ , further limiting the applicability of many techniques. Nuclear Magnetic Resonance (NMR) can be performed in situ, but not in conjunction with magic angle spinning (MAS), which is often needed to enhance sensitivity and resolve the broad signal associated with the crystalline environments making up the SEI. It has therefore been necessary to devise alternative NMR approaches to probe the SEI. Even in an isolated lithium metal electrode in contact with a standard electrolyte, an SEI forms and acts as an intermediary in the exchange between lithium ions in the electrolyte and the metal. Self-diffusion in the metal further complicates this picture, although its impact is only apparent when changes in the local 6 Li/ 7 Li isotopic concentration can be considered. This is possible with NMR and, coupled with the skin effect that limits the detected NMR signal to the micron-thickness surface region of the lithium metal, provides a unique, time resolved “window” into the lithium ion dynamics at the metal-SEI-electrolyte interfaces. We will describe how this “window” can be used to extract information about the growth of the SEI layer and measure the diffusion of lithium ions through it using NMR experiments on well-designed, isotopically-enriched systems (see Figure). Figure caption: Model of the ion dynamics at the lithium metal electrode – SEI – electrolyte interface. Information about the diffusion, exchange and transport properties of the ions through the SEI can be accessed via carefully designed 6 Li and 7 Li NMR experiments. Figure 1
NMR spectrum of benzo[b]furan in a nematic phase (1982)

Abstract The proton NMR spectrum of benzo[ b ]furan has been investigated in the nematic phase of a liquid crystal. Dipolar couplings obtained from the spectral analysis have been used to derive the interproton distance ratios. The phenyl ring geometry differs from that in benzo[ b ]thiophene. The deviations have been explained in terms of bond polarization effects.
Motion coordination through cooperative payload transport (2009)

In this paper we consider a group of agents collaboratively transporting a flexible payload. The reaction forces between the agents and the payload are modeled as the gradients of the nonlinear potentials that describe the deformation of the payload. We develop decentralized control laws without explicit communication such that the agents and the payload will eventually move with the same velocity meanwhile the contact forces are regulated.
Synthesis and structure of novel antimony thiametallacycles (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and structure of novel antimony thiametallacyclesStephen L. Buchwald, Richard A. Fisher, and William M. DavisCite this: Organometallics 1989, 8, 8, 2082–2084Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/om00110a049https://doi.org/10.1021/om00110a049research-articleACS PublicationsRequest reuse permissionsArticle Views147Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
TNK1 is a ubiquitin‐sensing kinase that can be targeted to block tumor growth (2022)

Thirty‐eight negative kinase‐1 (TNK1) is an understudied non‐receptor tyrosine kinase with no established function or mechanism of regulation. We recently identified TNK1 as the primary kinase driver of cell survival in subsets of patient blood cancer samples 1 . We discovered that one unusual feature of TNK1 is a functional ubiquitin‐association (UBA) domain that binds with high affinity to multiple poly‐ubiquitin linkages. Our recent 1.5 angstrom crystal structure of the TNK1 UBA shows an atypical five‐helix UBA domain with two predicted ubiquitin‐binding interfaces. We found that TNK1 relies on its UBA domain to home to phase‐separated poly‐ubiquitylated protein condensates and becomes fully active at these sites. To our knowledge, this feature of TNK1—a bona‐fide ubiquitin‐association domain that promotes kinase activation—makes TNK1 unique across the human kinome. Our data also suggest that 14‐3‐3 interacts with a MARK‐mediated phosphorylation at S502 of TNK1 to sequester the kinase away from ubiquitin and inhibit kinase activation. Thus, TNK1 toggles between poly‐ubiquitin bound (active) and 14‐3‐3‐bound (inactive) states. Our preliminary data suggest that the interaction with poly‐ubiquitin at condensates tethers TNK1 to substrates, facilitating its phosphorylation of substrates involved in the lysosomal degradation of condensates. Furthermore, we found that patient mutations that truncate the 14‐3‐3 binding site and UBA domain convert TNK1 into a cancer driver with an altered substrate profile, skewed toward pro‐growth substrates like STAT3. Finally, we show that mutant TNK1‐driven tumors can be targeted in vivo with a novel anti‐TNK1 small molecule. Thus, together our data suggest that TNK1 acts as a ubiquitin sensor and is a candidate for targeted therapy. 1. Chan TY and Egbert CM et al ., (2021) TNK1 is a ubiquitin‐binding and 14‐3‐3‐regulated kinase that can be targeted to block tumor growth. Nature Communications (in press)
Detrimental Hf penetration into TiN gate electrode and subsequent degradation in dielectric properties of HfSiO high-k film (2011)

Hafnium penetration through the TiN gate electrode as thick as 10 nm is detected in the TiN/HfSiO/SiO2 gate stacks after high-temperature annealing by using x-ray photoelectron spectroscopy. The Hf outdiffusion, showing TiN thickness dependence, is revealed to cause permittivity lowering of the pristine HfSiO high-k layer, which accelerates the equivalent oxide thickness increase and degrades the dielectric properties. In contrast, such diffusion is suppressed by adopting metal inserted polycrystalline silicon stack (MIPS) structure. Our further experiments indicate that the SiO2 regrowth during high-temperature annealing, which is hampered in MIPS structure, triggers the adverse Hf diffusion.
Systematic Review and Meta‐analysis of Outcomes of Patients With Subsegmental Pulmonary Embolism With and Without Anticoagulation Treatment (2018)

This systematic review highlights the lack of any clinical trial to make a clear inference about harm or benefit of anticoagulation for SSPE. Comparison of pooled data from uncontrolled outcome studies shows no increase in VTE recurrence or death rates for patients who were not anticoagulated. These data suggest clinical equipoise for decision to anticoagulate or not anticoagulate patients with SSPE. However, this inference is limited by small numbers, imprecision, and the lack of a controlled clinical trial.
Immonium Ion (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Helium in One-Dimensional Nanopores: Free Dispersion, Localization, and Commensurate/Incommensurate Transitions with Nonrigid Orbitals (2001)

The single-particle states of helium within a bundle of carbon nanotubes can range from nearly free-particle dispersion to localization, even within a single bundle. At intermediate effective masses, the corrugation in the external potential can be comparable to the intrasite He-He hard-core interaction. This results in a commensurate/incommensurate transition, where the mobility of the doubly occupied domain-wall solitons at high density greatly exceeds the corresponding hole mobility below the transition.