gebhart/patrepeval huggingface dataset:
Oxadiazole-Containing Macrocyclic Peptides Potentiate Azole Activity against Pathogenic Candida Species (2020)

Opportunistic pathogens of the genus <i>Candida</i> reign as the leading cause of mycotic disease and are associated with mortality rates greater than 40%, even with antifungal intervention. This is in part due to the limited arsenal of antifungals available to treat systemic fungal infections. Azoles have been the most widely deployed class of antifungal drug for decades and function by targeting the biosynthesis of ergosterol, a key component of the fungal cell membrane. However, their utility is compromised by their fungistatic nature, which favors the development of resistance. Combination therapy has the potential to confer enhanced efficacy as well as mitigate the evolution of resistance. Previously, we described the generation of structurally diverse macrocyclic peptides with a 1,3,4-oxadiazole and an endocyclic amine grafted within the peptide backbone. Importantly, this noncanonical backbone displayed high membrane permeability, an important attribute for compounds that need to permeate across the fungal cell wall and membrane in order to reach their intracellular target. Here, we explored the bioactivity of this novel chemical scaffold on its own and in combination with the azole fluconazole. Although few of the oxadiazole-containing macrocyclic peptides displayed activity against <i>Candida albicans</i> on their own, many increased the efficacy of fluconazole, resulting in a synergistic combination that was independent of efflux inhibition. Interestingly, these molecules also enhanced azole activity against several non-<i>albicans Candida</i> species, including the azole-resistant pathogens <i>Candida glabrata</i> and <i>Candida auris</i> This work characterizes a novel chemical scaffold that possesses azole-potentiating activity against clinically important <i>Candida</i> species.<b>IMPORTANCE</b> Fungal infections, such as those caused by pathogenic <i>Candida</i> species, pose a serious threat to human health. Treating these infections relies heavily on the use of azole antifungals; however, resistance to these drugs develops readily, demanding novel therapeutic strategies. This study characterized the antifungal activity of a series of molecules that possess unique chemical attributes and the ability to traverse cellular membranes. We observed that many of the compounds increased the activity of the azole fluconazole against <i>Candida albicans</i>, without blocking the action of drug efflux pumps. These molecules also increased the efficacy of azoles against other <i>Candida</i> species, including the emerging azole-resistant pathogen <i>Candida auris</i> Thus, we describe a novel chemical scaffold with broad-spectrum bioactivity against clinically important fungal pathogens.
Bother following stereotactic body radiation therapy for clinically localized prostate cancer. (2014)

195 Background: Stereotactic body radiation therapy (SBRT) delivers high doses of radiation while minimizing radiation to adjacent normal tissues. Large fraction sizes may increase the risk of functional decrements. However, treatment-related bother may be more important to a patient than treatment-related dysfunction. Methods: Between August 2007 and July 2011, 228 hormone-naïve patients with clinically localized prostate cancer were treated with 35-36.25 Gy SBRT delivered using the CyberKnife Radiosurgical System (Accuray) in five fractions. Patients completed the validated Expanded Prostate Cancer Index Composite (EPIC)-26 questionnaire at baseline, one month post-treatment, every three months the first year, then every six months. EPIC scores for bother range from 0 to 100 with lower values representing increased interference or annoyance caused by limitations in function. Results: Two hundred twenty eight patients at a median age of 69 (range, age 44 to 90) received SBRT with a minimum follow-up of 24 months. Urinary bother increased transiently first at one month and again at 12 months before returning to pre-treatment scores at two years: 80.2 (baseline); 68.2 (one month); 79.8 (three months); 78.3 (six months); 74.5 (nine months); 71.1 (12 months); 75.8 (18 months); 78.3 (24 months). Bowel bother followed a similar pattern but with a more protracted late-stage decline: 91.4 (baseline); 76.0 (one month); 87.8 (three months); 88.4 (six months); 85.8 (nine months); 85.7 (12 months); 87.8 (18 months); 90.1 (24 months). Sexual bother progressively worsened over two years: 65.9 (baseline); 64.8 (three months); 63.0 (six months); 63.2 (12 months); 59.0 (18 months); 58.4 (24 months). Conclusions: SBRT for clinically localized prostate cancer was well tolerated. Treatment-related bother was comparable to conventionally fractionated radiation therapy and brachytherapy. Transient late increases in urinary and bowel bother were observed at one year. Sexual bother steadily increased during the first two years following treatment.
Array Interpolation and Bias Reduction (2004)

Interpolation (mapping) of data from a given antenna array onto the output of a virtual array of more suitable configuration is well known in array signal processing. This operation allows arrays of any geometry to be used with fast direction-of-arrival (DOA) estimators designed for linear arrays. Conditions for preserving DOA error variance under such mappings have been derived by several authors. However, in many cases, such as omnidirectional signal surveillance over multiple octaves, systematic mapping errors will dominate over noise effects and cause significant bias in the DOA estimates. To prevent mapping errors from unduly affecting the DOA estimates, this paper uses a geometrical interpretation of a Taylor series expansion of the DOA estimator criterion function to derive an alternative design of the mapping matrix. Verifying simulations show significant bias reduction in the DOA estimates compared with previous designs. The key feature of the proposed design is that it takes into account the orthogonality between the manifold mapping errors and certain gradients of the estimator criterion function. With the new design, mapping of narrowband signals between dissimilar array geometries over wide sectors and large frequency ranges becomes feasible.
Lasing Actions in GaN Tiny Hexagonal Nanoring Resonators (2010)

We achieved optically pumped lasing actions of extremely small optical resonators, which have 1.4-2-μm-diameter GaN hexagonal nanorings with wall widths of 60-140 nm. The hexagonal nanorings were grown by rf-plasma molecular beam epitaxy (rf-MBE) with Ti-mask selective area growth (SAG). Due to the nanometer scale of the wall width, the propagation of threading dislocations through the wall was suppressed, and high crystalline quality of the nanoring resonators was achieved. The hexagonal nanorings possessed a fine cavity configuration of crystallographically flat outer walls and consisted of hexagonally connected sixfold side sections. The periodic boundary condition for each section with a short length limits the number of longitudinal resonance wavelengths, and narrowing the wall suppresses the occurrence of lasing in higher transverse modes. Therefore, both contribute to the lasing action in a single longitudinal mode of the hexagonal nanoring.
3D Reconstruction of the Neurovascular Unit Reveals Differential Loss of Cholinergic Innervation in the Cortex and Hippocampus of the Adult Mouse Brain (2019)

Increasing evidence supports a role for cerebrovasculature dysfunction in the etiology of Alzheimer's disease (AD). Blood vessels in the brain are composed of a collection of cells and acellular material that comprise the neurovascular unit (NVU). The NVU in the hippocampus and cortex receives innervation from cholinergic neurons that originate in the basal forebrain. Death of these neurons and their nerve fibers is an early feature of AD. However, the effect of the loss of cholinergic innervation on the NVU is not well characterized. The purpose of this study was to evaluate the effect of the loss of cholinergic innervation of components of the NVU at capillaries, arteries and veins in the hippocampus and cortex. Adult male C57BL/6 mice received an intracerebroventricular injection of the immunotoxin p75NTR mu-saporin to induce the loss of cholinergic neurons. Quadruple labeling immunohistochemistry and 3D reconstruction were carried out to characterize specific points of contact between cholinergic fibers and collagen IV, smooth muscle cells and astrocyte endfeet. Innate differences were observed between vessels of the hippocampus and cortex of control mice, including a greater amount of cholinergic contact with perivascular astrocytes in hippocampal capillaries and a thicker basement membrane in hippocampal veins. Saporin treatment induced a loss of cholinergic innervation at the arterial basement membrane and smooth muscle cells of both the hippocampus and the cortex. In the cortex, there was an additional loss of innervation at the astrocytic endfeet. The current results suggest that cortical arteries are more strongly affected by cholinergic denervation than arteries in the hippocampus. This regional variation may have implications for the etiology of the vascular pathology that develops in AD.
Nanoscale heterogeneity of ultrafast many-body carrier dynamics in triple cation perovskites (2022)

In high fluence applications of lead halide perovskites for light-emitting diodes and lasers, multi-polaron interactions and associated Auger recombination limit the device performance. However, the relationship of the ultrafast and strongly lattice coupled carrier dynamics to nanoscale heterogeneities has remained elusive. Here, in ultrafast visible-pump infrared-probe nano-imaging of the photoinduced carrier dynamics in triple cation perovskite films, a ~20 % variation in sub-ns relaxation dynamics with spatial disorder on tens to hundreds of nanometer is resolved. We attribute the non-uniform relaxation dynamics to the heterogeneous evolution of polaron delocalization and increasing scattering time. The initial high-density excitation results in faster relaxation due to strong many-body interactions, followed by extended carrier lifetimes at lower densities. These results point towards the missing link between the optoelectronic heterogeneity and associated carrier dynamics to guide synthesis and device engineering for improved perovskites device performance.
Cooperative red teaming of a prototype surivable service-oriented system (2012)

An increasing number of military systems are being developed using service orientation. Some of the features that make service orientation appealing, like loose coupling, dynamism and composition-oriented system construction, make securing service-based systems more complicated. We have been developing technologies for Advanced Protected Services (APS) to improve the resilience and survival of services under cyber attack. These technologies introduce a layer to absorb, contain, and adapt to cyber attacks before attacks reach critical services. This paper describes an evaluation of these advanced protection technologies using cooperative red teaming. In cooperative red teaming, an independent red team launches attacks on a protected enclave in order to evaluate the efficacy and efficiency of the protection technologies, but the red team is provided full knowledge of the system under test and its protections, and is given escalating levels of access to the system. The red team also operates within agreed upon rules of engagement designed to focus their effort on useful evaluation results. Apart from presenting the evaluation results, we also discuss cooperative red teaming as an effective means of evaluating cyber security.
Abstract 742: A novel multidrug metronomic chemotherapy significantly delays tumor growth in mice (2016)

Abstract The tumor immunosuppressive microenvironment represents a major obstacle to an effective tumor-specific cellular immune response. We have previously shown that a novel multi-drug chemotherapy administered in a metronomic fashion was able to increase immune response to peptides. The chemotherapy consisted of a cocktail including taxanes (paclitaxel and docetaxel) and alkylating (cyclophosphamide) agents. The newly designed strategy was shown to be safe, well tolerated and significantly efficacious (Tagliamonte et al., CII 2015). In the present study, the effect on the immunosuppressive tumor microenvironment by the same multi-drug cocktail was evaluated in a mouse model upon sub-cutaneous ectopic implantation of B16 melanoma cells. Treated animals showed a remarkable delay in tumor growth and prolonged survival as compared to control group. Such an effect was directly correlated with CD4+ T cell reduction and CD8+ T cell increase. A significant reduction in the percentage of both CD25+FoxP3+ and CD25+CD127low regulatory T cell population was found in the spleens as well as in the tumor lesions. An intrinsic CD8+ T cell response specific to B16 naturally expressed Trp2 TAA was observed. The same metronomic chemotherapy combined to a vaccine based on mutated antigens, was subsequently shown to increase immune response to vaccine resulting in a significant delay of B16 tumor growth as well as animal survival. The novel multi-drug daily metronomic chemotherapy evaluated in the present study was very effective in counterbalancing the immunosuppressive tumor microenvironment and enhancing vaccine efficacy. Consequently, the intrinsic as well as vaccine-induced anti-tumor T cell immunity could exert its function containing tumor growth. Overall, the described metronomic chemotherapy may represent a promising adjuvant approach to enhance anti-tumor cellular immunity and amplify the biological effects of therapeutic cancer vaccines. Citation Format: Maria Tagliamonte, Annacarmen Petrizzo, Maria Lina Tornesello, Antonio Luciano, Domenica Rea, Antonio Barbieri, Claudio Arra, Maria Napolitano, Gennaro Ciliberto, Franco M. Buonaguro, Luigi Buonaguro. A novel multidrug metronomic chemotherapy significantly delays tumor growth in mice. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 742.
G.fast: evolving the copper access network (2013)

Continuous improvements in communication technologies over copper pair access networks have enabled hybrid fiber/copper access networks that provide ever increasing broadband data rates. Most recently, field trials have demonstrated that crosstalk cancellation, also referred to as vectoring, and bonding two pairs to push data rates of very high speed DSL above 100 Mb/s on a single copper pair and above 200 Mb/s on two copper pairs. Looking ahead, the G.fast project group of the ITU-T is currently defining a new copper access technology to provide aggregate (upstream and downstream) data rates of up to 1 Gb/s over distances up to 250 m. This article provides an overview of some key challenges that need to be addressed for G.fast.
Randomized trial of 10 days of decitabine ± bortezomib in untreated older patients with AML: CALGB 11002 (Alliance) (2018)

Novel treatment strategies are needed for older patients with acute myeloid leukemia (AML). This randomized phase 2 trial compared the efficacy and safety of 20 mg/m<sup>2</sup> of IV decitabine on days 1 to 10 alone (arm A) with those of 1.3 mg/m<sup>2</sup> of subcutaneous bortezomib (arm B) on days 1, 4, 8, and 11 for up to 4 10-day cycles followed by monthly 5-day cycles. Previously untreated AML patients age ≥60 years (excluding those with <i>FLT3</i> mutations and favorable-risk cytogenetics) without restrictions in performance status (PS) or organ function were eligible. Median age was 72.4 years (range, 60.5-92.3 years); 31 patients (19%) had baseline PS ≥2, 35 (22%) had an antecedent hematological disorder, 58 had (39%) adverse cytogenetics, and 7 (5%) and 23 (14%) had abnormal cardiac or renal function. There were no statistically significant differences in overall survival (OS) or responses between the 2 treatment arms. The overall response rate (complete remission + complete remission with incomplete blood count recovery) was 39% (n = 64), with median OS of 9.3 months. Nineteen responders (31%) underwent allogeneic stem cell transplantation. The most common adverse event was febrile neutropenia, and there were no unexpected toxicities. Adding bortezomib to decitabine did not improve outcomes, but responses were better than those in previous trials using 5-day decitabine cycles. This trial was registered at www.clinicaltrials.gov as #NCT01420926.
Process for fabricating PBI hollow fiber asymmetric membranes for gas separation and liquid separation (2023)

The invention provides methods for preparing an asymmetric hollow fiber, the asymmetric hollow fibers prepared by such methods, and uses of the asymmetric hollow fibers. One method involves passing a polymeric solution through an outer annular orifice of a tube-in-orifice spinneret, passing a bore fluid though an inner tube of the spinneret, dropping the polymeric solution and bore fluid through an atmosphere over a dropping distance, and quenching the polymeric solution and bore fluid in a bath to form an asymmetric hollow fiber.
Ba3CrN3H: A New Nitride-Hydride with Trigonal Planar Cr4+ (2018)

Single crystal synthesis of a new nitride-hydride Ba3CrN3H. X-ray diffraction, nuclear magnetic resonance, and bond-valance sum and density functional theory calculations confirmed the presence and location of the anionic hydrogen in this compound.
The Promise of SOFC Power Generation Technology (2001)

This chapter contains sections titled: Introduction Technology System Status Conclusion
Detection of HIV-1 P24 Gag in Plasma by a Nanoparticle-Based Bio-Barcode-Amplification Method (2008)

The bio-barcode-amplification method was superior to the conventional ELISA assay for the detection of HIV-1 p24 Gag protein in plasma with a breadth of coverage for diverse HIV-1 subtypes. Because the bio-barcode-amplification method does not require enzymatic amplification, this method could be translated into a robust point-of-care test.
New Therapy for Central Retinal Vein Occlusion (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
ChemInform Abstract: REACTIONS OF ORGANOCYCLOPROPANES AND SPIROCYCLES WITH METAL ATOMS (1979)

Abstract Generelle Bedingungen für die Reaktion von organischen Cyclopropan‐Derivaten mit Metallen, die unter Spaltung einer C‐C‐Bindung zu Metallkomplexen führen, werden gesucht.
Reliable Data Transmission for Resonant-Type Wireless Power Transfer (2012)

Wireless power transfer research has been receiving a great deal of attention in recent years. In resonant-type wireless power transfer, energy is transferred via LC resonant circuits. However, system performance is dependent on the circuit components. To transfer power efficiently and safely, information, such as frequency, required power and element values, need to be transmitted reliably in the system. This paper investigates data communication using orthogonal frequency division multiplexing (OFDM) modulation in resonant-type wireless power transfer systems. The equivalent circuit used in the transmitting and receiving antennas is a band pass filter (BPF) and its bandwidth is evaluated through circuit simulations and experimental measurements. Numerical results obtained through computer simulation show that the bit error rate (BER) performance is affected by the splitting resonant frequency.
A Novel Racing Array Transducer for Noninvasive Ultrasonic Retinal Stimulation: A Simulation Study (2019)

Neurostimulation has proved to be an effective method for the restoration of visual perception lost due to retinal diseases. However, the clinically available retinal neurostimulation method is based on invasive electrodes, making it a high-cost and high-risk procedure. Recently, ultrasound has been demonstrated to be an effective way to achieve noninvasive neurostimulation. In this work, a novel racing array transducer with a contact lens shape is proposed for ultrasonic retinal stimulation. The transducer is flexible and placed outside the eyeball, similar to the application of a contact lens. Ultrasound emitted from the transducer can reach the retina without passing through the lens, thus greatly minimizing the acoustic absorption in the lens. The discretized Rayleigh-Sommerfeld method was employed for the acoustic field simulation, and patterned stimulation was achieved. A 5 MHz racing array transducer with different element numbers was simulated to optimize the array configuration. The results show that a 512-element racing array is the most appropriate configuration considering the necessary tradeoff between the element number and the stimulation resolution. The stimulation resolution at a focus of 24 mm is about 0.6 mm. The obtained results indicate that the proposed racing array design of the ultrasound transducer can improve the feasibility of an ultrasound retinal prosthesis.
The magnetic circular dichroism of 1-azabicyclo[2,2,2]octane (ABCO) in the n→3p region (1986)

An MCD and absorption spectra measured in the energy region of the second excited state of 1-azabicyclo[2,2,2]octane (ABCO) reveal large positive A terms. Simple calculations of the magnetic moment of a 1E excited state yield also a positive sign for the A terms. A small negative B term is observed 355 cm−1 below the origin of the 1E state. Based on B term calculations we assign it as the 1A1→1A1 transition (n0→3pz). The results are compared with a recent MPI study in the same energy range.
Screening to Detect Precursor Lesions of Pancreatic Adenocarcinoma in High-risk Individuals: A Single-center Experience (2018)

Adherence was an important limiting factor in screening. Better stratification of patients according to specific risk factors, including thorough genetics and family history, may direct when and how to initiate screening. International collaborations, such as the International Cancer of Pancreas Screening (CAPS) Consortium, of which Rambam is a collaborating partner, are needed to collate evidence for impact of screening to prevent pancreatic cancer morbidity and mortality, and are essential to achieve proof of concept. Different countries with varying health-care systems and budgets can find variance of appropriateness of screening procedures.