gebhart/patrepeval huggingface dataset:
NT-020, a Natural Therapeutic Approach to Optimize Spatial Memory Performance and Increase Neural Progenitor Cell Proliferation and Decrease Inflammation in the Aged Rat (2010)

The process of aging is linked to oxidative stress, microglial activation, and proinflammatory factors, which are known to decrease cell proliferation and limit neuroplasticity. These factors may lead the transition from normal aging to more severe cognitive dysfunction associated with neurodegenerative diseases. We have shown that natural compounds such as polyphenols from blueberry and green tea and amino acids like carnosine are high in antioxidant and antiinflammatory activity that decreases the damaging effects of reactive oxygen species (ROS), in the blood, brain, and other tissues of the body. Furthermore, we have shown that the combination of these nutrients (called NT-020) creates a synergistic effect that promotes the proliferation of stem cells in vitro and in vivo. In the current study, we examined the effects of NT-020 on neurogenesis and performance on a Morris water maze (MWM). Aged (20-month-old) male Fischer 344 rats were treated with 135.0 mg/kg per day (n = 13) of NT-020. Young (3-month-old) (n = 10) and aged (20-month-old) (n = 13) control male Fischer 344 rats were treated with water by oral gavage. All groups were treated for a period of 4 weeks. Although there was no difference in performance in the MWM when comparing all aged rats, when the data for aged impaired rats were compared, there was a significant difference between groups on the last day of training with the treatment group performing better than controls. Using the cell cycle-regulating protein (Ki67), doublecortin (DCX), and OX6 antibody markers, cell proliferation, neurogenesis, and microglial activation were estimated in the dentate gyrus (DG) of young and aged animals. Cell proliferation was also examined in the subventricular zone (SVZ). A decreased number of OX6 MHC II-positive cells, increased neurogenesis, and increased number of proliferating cells were found in rats treated with NT-020 in comparison with aged control rats. In sum, NT-020 may promote health, proliferation, and maintenance of neurons in the age animals and exert antiinflammatory actions that promote function in the aged stem cell niche.
Patent Update Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Neurokinin receptor antagonists for the treatment of inflammation (1996)

Since the identification of the nonpeptide tachykinin antagonists CP–96345 (Pfizer) and SR-48968 (Sanofi), interest in this area of research has increased markedly with several pharmaceutical companies actively patenting structures for a range of therapeutic applications. This review surveys the activity of several pharmaceutical companies in the patent literature during January through December 1995.
The KITD816V allele burden predicts survival in patients with mastocytosis and correlates with the WHO type of the disease (2014)

KIT D816V is present in a majority of patients with systemic mastocytosis (SM). We determined the KIT D816V allele burden by quantitative real-time PCR in bone marrow and peripheral blood of 105 patients with mastocytosis. KIT D816V was detected in 92/105 patients (88%). Significant differences in the median allele burden were observed between disease subgroups: cutaneous mastocytosis (0.042%), indolent SM (0.285%), smoldering SM (5.991%), aggressive SM (9.346%), and SM with associated hematologic non-mast cell lineage disease (3.761%) (P < 0.001). The KIT D816V burden also correlated with serum tryptase (R = 0.5, P < 0.005) but not with mast cell infiltration in bone marrow or mediator symptoms. Moreover, the allele burden was of prognostic significance regarding survival (P < 0.01). Patients responding to cytoreductive therapy showed a significant decrease in KIT D816V (P < 0.05). To conclude, the KIT D816V burden correlates with the variant of mastocytosis, predicts survival, and is a valuable follow-up parameter in SM.
Heat Release and Knock in Paraffinic and Aromatic Fuels and the Effect of an Ashless Anti-knock Additive (1995)

&lt;div class="htmlview paragraph"&gt;Net heat release rates and knock characteristics were derived from in-cylinder pressures for different fuels in a single-cylinder engine; the effect of an ashless antiknock, N-methyl aniline (NMA) was also studied. The maximum net heat release rate (MHRR) resulting from the final high-temperature chemistry determines the knock intensity. Paraffinic fuels have similar knock intensities at comparable knock occurrence frequencies. Aromatic fuels have significantly lower MHRRs and give much lower mean knock intensities for a given knock occurrence frequency compared to paraffinic fuels. Adding NMA to a paraffinic fuel increases the spark advance required to get a chosen frequency of knock occurrence as it increases the octane number of the fuel but has little effect on MHRR and hence knock intensity.&lt;/div&gt;
Fluorogenic monomer activation for protein-initiated atom transfer radical polymerization (2022)

Fluorogenic atom transfer radical polymerization (ATRP) directly detects initiator-dependent polymer formation, as initially non-fluorescent polycyclic aromatic probe monomers reveal visible fluorescence upon polymerization in real time. Advancement of this initial proof-of-concept toward biodetection applications requires both a more detailed mechanistic understanding of probe fluorescence activation, and the ability to initiate fluorogenic polymerization directly from a biomolecule surface. Here, we show that simple monomer hydrogenation, independent of polymerization, reveals probe fluorescence, supporting the critical role of covalent enone attachment in fluorogenic probe quenching and subsequent fluorescence activation. We next demonstrate bioorthogonal, protein-initiated fluorogenic ATRP by the surface conjugation and characterization of protein-initiator conjugates of a model protein, bovine serum albumin (BSA). Fluorogenic ATRP from initiator-modified protein allows for real-time visualization of polymer formation with negligible background fluorescence from unmodified BSA controls. We further probe the bioorthogonality of this fluorogenic ATRP assay by assessing polymer formation in a complex biological environment, spiked with fetal bovine serum. Taken together, we demonstrate the potential of aqueous fluorogenic ATRP as a robust, bioorthogonal method for biomolecular-initiated polymerization by real-time fluorescence activation.
Improved Electron-Beam/Deep-Ultraviolet Intralevel Mix-and-Match Lithography with 100 nm Resolution (1999)

We have developed a novel electron-beam (e-beam)/deep-ultraviolet (DUV) intralevel mix-and-match (ILM&amp;M) lithography as a production-viable technology. The main feature of the ILM&amp;M lithography is its use of a DUV biased exposure method for increased throughput and a combination of a variably shaped e-beam/character projection writer with a step-and-repeat DUV scanning system for accurate intralevel butting between e-beam and DUV patterns. It was demonstrated that the throughput of e-beam writing in the ILM&amp;M lithography could reach about three times that of e-beam lithography, and that an intralevel butting accuracy of less than 50 nm could be achieved. The proposed ILM&amp;M has been successfully applied to the development and early production of leading edge devices at our laboratory.
Segmented diffusion imaging with iterative motion‐corrected reconstruction (SEDIMENT) for brain echo‐planar imaging (2019)

Multi-shot techniques offer improved resolution and signal-to-noise ratio for diffusion- weighted imaging, but make the acquisition vulnerable to shot-specific phase variations and inter-shot macroscopic motion. Several model-based reconstruction approaches with iterative phase correction have been proposed, but robust macroscopic motion estimation is still challenging. Segmented diffusion imaging with iterative motion-corrected reconstruction (SEDIMENT) uses iteratively refined data-driven shot navigators based on sensitivity encoding to cure phase and rigid in-plane motion artifacts. The iterative scheme is compared in simulations and in vivo with a non-iterative reference algorithm for echo-planar imaging with up to sixfold segmentation. The SEDIMENT framework supports partial Fourier acquisitions and furthermore includes options for data rejection and learning-based modules to improve robustness and convergence.
Cigarette smoke exposure potentiates bleomycin-induced lung fibrosis in guinea pigs (2003)

The role of tobacco smoking in the development and outcome of pulmonary fibrosis is uncertain. To approach the effects of cigarette smoke on bleomycin-induced lung fibrosis, we studied five groups of guinea pigs: 1) controls, 2) instilled with bleomycin (B), 3) exposed to tobacco smoke for 6 wk (TS), 4) bleomycin instillation plus tobacco smoke exposure for 6 wk (B+TS), and 5) tobacco smoke exposure for 6 wk and bleomycin after smoking (TS/B). Guinea pigs receiving bleomycin and tobacco smoke exposure exhibited higher fibrotic lesions including a significant increase in the number of positive alpha-smooth muscle actin cells compared with bleomycin alone (B+TS, 3.4 +/- 1.2%; TS/B, 3.7 +/- 1.5%; B, 2.3 +/- 1.5%; P < 0.01). However, only the TS/B group reached a significant increase in lung collagen compared with the bleomycin group (TS/B, 3.5 +/- 0.7; B +/- TS, 2.9 +/- 0.4; B, 2.4 +/- 0.2 mg hydroxyproline/lung; P < 0.01). Bronchoalveolar lavage (BAL) from TS/B showed an increased number of eosinophils and higher levels of IL-4 and tissue inhibitor of metalloproteinase-2 (P < 0.01 for all comparisons) and induced a significant increase in fibroblast proliferation (P < 0.05). Importantly, smoke exposure alone induced an increase in BAL neutrophils, matrix metalloproteinase-9, and fibroblast proliferation compared with controls, suggesting that tobacco smoke creates a profibrotic milieu that may contribute to the increased bleomycin-induced fibrosis.
ChemInform Abstract: Benzylated 1,2,3‐Triazoles as Anticoccidiostats. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tolerability and Safety of Combined Glatiramer Acetate and N-Acetylcysteine in Relapsing-Remitting Multiple Sclerosis (2015)

In light of the favorable safety profile, an efficacy-demonstrating study may be considered.
Unrepeatered transmission over 300km non-zero dispersion-shifted fiber with bi-directionally pumped Raman amplification (2005)

We have demonstrated the unrepeatered transmission of 20×10.66Gbit/s over 300km non-zero dispersion-shifted fiber with conventional NRZ modulation format by using bi-directionally pumped Raman amplification, as opposed to hybrid fiber types or remotely pumped EDF. (2 pages)
System electronics for the MiCES small animal PET scanner (2003)

The final electronics system for the microcrystal element scanner (MiCES) small animal positron emission tomograph is described. Groups of four position-sensitive photomultiplier tubes (FSPMTs) are connected to an adapter board which provides four output signals from each PSPMT. The adapter board outputs are routed to an analog processing board which contains application specific integrated circuits (ASIC) for signal amplification, base line restoration, and time to digital conversion. The amplified signals are continuously digitized and the data routed to field programmable gate arrays (FPGA). Each analog board is configured into two independent channels, each channel processing the data from two PSPMTs. The digital data is routed to a digital board that includes a microprocessor and a 1394a (FireWire) bus controller. The MiCES uses 18 board sets to process signals from 72 PSPMTs. In addition, a coincidence controller imposes a rough coincidence window on the data. Finally, a motion controller drives the gantry table and the rotation motors. All of the electronics with the exception of the motion controller, power supplies, and host computer rotate with the detector array. The low speed signal and power buses are connected to the electronics via a slip ring. The 1394a bus is connected to the host computer via a rotating optical coupler and 1394a copper to optical converters.
Productive petascale computing: requirements, hardware, and software (2009)

Supercomputer designers traditionally focus on low-level hardware performance criteria such as CPU cycle speed, disk bandwidth, and memory latency. The High-Performance Computing (HPC) community has more recently begun to realize that escalating hardware performance is, by itself, contributing less and less to real productivity—the ability to develop and deploy high-performance supercomputer applications at acceptable time and cost. The Defense Advanced Research Projects Agency (DARPA) High Productivity Computing Systems (HPCS) initiative challenged industry vendors to design a new generation of supercomputers that would deliver a 10x improvement in this newly acknowledged but poorly understood domain of real productivity. Sun Microsystems, choosing to abandon customary evolutionary approaches, responded with two revolutionary decisions. The first was to investigate the nature of supercomputer productivity in the full context of use, which includes people, organizations, goals, practices, and skills as well as processors, disks, memory, and software. The second decision was to rethink completely the design of supercomputing systems, informed by productivity-based requirements and driven by recent technological breakthroughs. Crucial to the implementation of these decisions was the establishment of multidisciplinary, closely collaborating teams that conducted research
The Latin American Idiopathic Pulmonary Fibrosis Registry (REFIPI): Baseline Characteristics (2019)

<b>Background:</b> There is an urgent need for large longitudinal registries to evaluate the long-term clinical course of IPF and impact of treatment in real-world clinical setting. In November 2017, we started the first Latin American registry (REFIPI) with participation of 11 countries. <b>Methods:</b> In the first year, 433 IPF patients confirmed by central multidisciplinary diagnostic team were added. ILD without HRCT or biopsy UIP-pattern confirmation were ruled out. Demographic variables, functional tests, treatment and evolution were analyzed. <b>Results:</b> Mean(SD) age was 71+8 years, 77% males, most former smokers (53%). Family history of pulmonary fibrosis was reported in 6%. Time of symptoms before diagnosis was 18+17 months, 99% with Velcro rales, 42% clubbing and 38% had gastroesophageal reflux. All of them had restrictive pattern in spirometry and DLCO was 55+41% of predicted at diagnosis. In HRCT 71% has UIP and 29% possible UIP. Lung biopsy was obtained in 16% of the patients showing UIP pattern. At inclusion, 68% received pirfenidone, 18% nintedanib, and 3% azathioprine, prednisone, n-acetylcysteine, 11% weren’t receiving treatment. 9% presented an acute exacerbation and 92% of them were treated with high dose of corticosteroids during the event. In this first year, 13% of patients died, 81% IPF related. <b>Conclusions:</b> A large number of patients were enrolled in our initial Latino American registry of IPF. Our results are similar to reported male and smoking predominance, and some with family history of lung fibrosis. Time of symptoms befor diagnosis indicate the lack of knowledge about this disease by general clinicians. However, most patients seen by pulmonologist, received antifibrotic drugs.
A Single Gβ Subunit Locus Controls Cross-talk between Protein Kinase C and G Protein Regulation of N-type Calcium Channels (2004)

The modulation of N-type calcium channels is a key factor in the control of neurotransmitter release. Whereas N-type channels are inhibited by Gbetagamma subunits in a G protein beta-isoform-dependent manner, channel activity is typically stimulated by activation of protein kinase C (PKC). In addition, there is cross-talk among these pathways, such that PKC-dependent phosphorylation of the Gbetagamma target site on the N-type channel antagonizes subsequent G protein inhibition, albeit only for Gbeta(1)-mediated responses. The molecular mechanisms that control this G protein beta subunit subtype-specific regulation have not been described. Here, we show that G protein inhibition of N-type calcium channels is critically dependent on two separate but adjacent approximately 20-amino acid regions of the Gbeta subunit, plus a highly conserved Asn-Tyr-Val motif. These regions are distinct from those implicated previously in Gbetagamma signaling to other effectors such as G protein-coupled inward rectifier potassium channels, phospholipase beta(2), and adenylyl cyclase, thus raising the possibility that the specificity for G protein signaling to calcium channels might rely on unique G protein structural determinants. In addition, we identify a highly specific locus on the Gbeta(1) subunit that serves as a molecular detector of PKC-dependent phosphorylation of the G protein target site on the N-type channel alpha(1) subunit, thus providing for a molecular basis for G protein-PKC cross-talk. Overall, our results significantly advance our understanding of the molecular details underlying the integration of G protein and PKC signaling pathways at the level of the N-type calcium channel alpha(1) subunit.
Stoffeigenschaften von Polymeren (2016)

No AccessDer gleichläufige DoppelschneckenextruderOct 2016Stoffeigenschaften von PolymerenKlemens KohlgrüberKlemens Kohlgrüberhttps://doi.org/10.3139/9783446435971.003SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2016Pages: 203-315Print ISBN: 978-3-446-43361-8eISBN: 978-3-446-43597-1 Copyright & Permissions© 2016 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
AICA riboside both activates AMP‐activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus (2004)

5-Aminoimidazole-4-carboxamide riboside (AICA riboside; Acadesine) activates AMP-activated protein kinase (AMPK) in intact cells, and is reported to exert protective effects in the mammalian CNS. In rat cerebrocortical brain slices, AMPK was activated by metabolic stress (ischaemia > hypoxia > aglycaemia) and AICA riboside (0.1-10 mm). Activation of AMPK by AICA riboside was greatly attenuated by inhibitors of equilibrative nucleoside transport. AICA riboside also depressed excitatory synaptic transmission in area CA1 of the rat hippocampus, which was prevented by an adenosine A1 receptor antagonist and reversed by application of adenosine deaminase. However, AICA riboside was neither a substrate for adenosine deaminase nor an agonist at adenosine receptors. We conclude that metabolic stress and AICA riboside both stimulate AMPK activity in mammalian brain, but that AICA riboside has an additional effect, i.e. competition with adenosine for uptake by the nucleoside transporter. This results in an increase in extracellular adenosine and subsequent activation of adenosine receptors. Neuroprotection by AICA riboside could be mediated by this mechanism as well as, or instead of, by AMPK activation. Caution should therefore be exercised in ascribing an effect of AICA riboside to AMPK activation, especially in systems where inhibition of adenosine re-uptake has physiological consequences.
Vibration Detection and Localization in Buried Fiber Cable after 80km of SSMF using Digital Coherent Sensing System with Co-Propagating 600Gb/s WDM Channels (2022)

We report detection-localization-identification of true mechanical events on a buried fiber cable up to 82km SSMF using a digital sensing system copropagating with adjacent 600Gb/s WDM channels. Non-intrusive coexistence with WDM channels is demonstrated.
Managing Messes in Computational Notebooks (2019)

Data analysts use computational notebooks to write code for analyzing and visualizing data. Notebooks help analysts iteratively write analysis code by letting them interleave code with output, and selectively execute cells. However, as analysis progresses, analysts leave behind old code and outputs, and overwrite important code, producing cluttered and inconsistent notebooks. This paper introduces code gathering tools, extensions to computational notebooks that help analysts find, clean, recover, and compare versions of code in cluttered, inconsistent notebooks. The tools archive all versions of code outputs, allowing analysts to review these versions and recover the subsets of code that produced them. These subsets can serve as succinct summaries of analysis activity or starting points for new analyses. In a qualitative usability study, 12 professional analysts found the tools useful for cleaning notebooks and writing analysis code, and discovered new ways to use them, like generating personal documentation and lightweight versioning.
Lost but making progress—Where will new analgesic drugs come from? (2014)

There is a critical need for effective new pharmacotherapies for pain. The paucity of new drugs successfully reaching the clinic calls for a reassessment of current analgesic drug discovery approaches. Many points early in the discovery process present significant hurdles, making it critical to exploit advances in pain neurobiology to increase the probability of success. In this review, we highlight approaches that are being pursued vigorously by the pain community for drug discovery, including innovative preclinical pain models, insights from genetics, mechanistic phenotyping of pain patients, development of biomarkers, and emerging insights into chronic pain as a disorder of both the periphery and the brain. Collaborative efforts between pharmaceutical, academic, and public entities to advance research in these areas promise to de-risk potential targets, stimulate investment, and speed evaluation and development of better pain therapies.
A Leakage Flux Cancellation Technique for Series-Parallel Combined Resonant Circuits with Asymmetric Rotary Transformers Used for Ultrasonic Spindle Drive (2018)

This paper proposes a novel leakage flux cancellation technique suitable for series-parallel combined resonant circuits with asymmetric rotary transformer used for ultrasonic spindles drive. An asymmetric rotary transformer is utilized in the ultrasonic spindle in order to realize automated tool change. However, an asymmetric rotary transformer is likely to occur much leakage fluxes in secondly core due to asymmetric core structures. This large leakage inductance affects a drive circuit using a series-parallel combined resonant circuit, and the resonant characteristics in the drive circuit become very steep. In this state, the resonance circuit does not realize the desired function when the drive frequency fluctuates or the error of resonance parameters occurs. Therefore, this paper proposes a novel leakage flux cancellation technique used for ultrasonic spindle drive. The effectiveness of the proposed method is discussed from the theoretical analysis and experimental test.
优化安全工作区（SOA）性能的下一代IGCT (2007)

为了改进电力电子系统的性能、减小其尺寸以及降低成本，大功率半导体器件将继续朝着高电压和大电流容量的方向发展。IGCT也不例外。本文描述具有电压额定值为4．5kV～6．5kV的一个新的IGCT系列的高安全工作区（SOA）能力。