gebhart/patrepeval huggingface dataset:
Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion (2021)

Abstract Many cadherin family proteins are associated with diseases such as cancer. Since cell adhesion requires homodimerization of cadherin molecules, a small-molecule regulator of dimerization would have therapeutic potential. Herein, we describe identification of a P-cadherin-specific chemical fragment that inhibits P-cadherin-mediated cell adhesion. Although the identified molecule is a fragment compound, it binds to a cavity of P-cadherin that has not previously been targeted, indirectly prevents formation of hydrogen bonds necessary for formation of an intermediate called the X dimer and thus modulates the process of X dimerization. Our findings will impact on a strategy for regulation of protein-protein interactions and stepwise assembly of protein complexes using small molecules.
Overexpression of Merlin in B16F10 mouse melanoma cells reduces their metastatic activity: Role of the cell surface heparan sulfate glycosaminoglycans (1992)

Merlin, the protein product of the neurofibromatosis type 2 gene (NF2) acts as a tumor suppressor in mice and humans. In this study, melanoma B16F10 cells were engineered to overexpress the NF2 gene by establishing stable transductants. A cell line overexpressing Merlin (B16F10-M) was generated. When compared to the parental cells, the B16F10-M cells demonstrated differences in their cell surface organization. The overexpressing strain changed its ability to grow in soft agar as well as its cell motility properties. B16F10-M cells were then examined in the in vivo mouse melanoma tumor growth and tumor metastasis models. While tumor growth was marginally affected, the presence of increased Merlin severely reduced the metastastatic ability of the cells. When isolated using specific enzymes with distinct substrate specificity, the cell surface heparan sulfate glycosaminoglycans (HSGAGs) from the overexpressing B16F10-M cells, inhibited the metastatic properties of the parental B16F10 cells. The results obtained provide a causal link between the reorganization/changes to the cell surface HSGAGs by the overexpression of Merlin and the inhibition of the metastatic activity of the mouse melanoma B16F10 cells in vivo.
Proportional Tumor Infiltration of T Cells via Circulation Duplicates the T Cell Receptor Repertoire in a Bilateral Tumor Mouse Model (2021)

Temporal analysis of the T cell receptor (TCR) repertoire has been used to monitor treatment-induced changes in antigen-specific T cells in patients with cancer. However, the lack of experimental models that allow a temporal analysis of the TCR repertoire in the same individual in a homogeneous population limits the understanding of the causal relationship between changes in TCR repertoire and antitumor responses. A bilateral tumor model, where tumor cells were inoculated bilaterally into the backs of mice, could be used for temporal analysis of the TCR repertoire. This study examined the prerequisite for this strategy: the TCR repertoire is conserved between bilateral tumors that grow symmetrically. Bilateral tumors and draining lymph nodes (dLNs) were collected 13 days after tumor inoculation to analyze the TCR repertoire of CD4<sup>+</sup> and CD8<sup>+</sup> T cells. The tumor-infiltrating T-cell clones were highly similar between the bilateral tumors and expanded to a similar extent. In addition, the differences of TCR repertoire between the bilateral tumors were equivalent to Intra-tumoral heterogeneity on one side. On the other hand, the similarity of the TCR repertoire in the bilateral dLNs was markedly lower than that in the tumor, suggesting that tumor-reactive T cell clones induced independently in each dLN are mixed during recirculation and then proportionally infiltrated the bilateral tumors. These findings provide the basis for future analysis of temporal and treatment-induced changes in tumor-reactive T cell clones using this bilateral tumor model.
Convexity Shape Constraints for Image Segmentation (2015)

Segmenting an image into multiple components is a central task in computer vision. In many practical scenarios, prior knowledge about plausible components is available. Incorporating such prior knowledge into models and algorithms for image segmentation is highly desirable, yet can be non-trivial. In this work, we introduce a new approach that allows, for the first time, to constrain some or all components of a segmentation to have convex shapes. Specifically, we extend the Minimum Cost Multicut Problem by a class of constraints that enforce convexity. To solve instances of this APX-hard integer linear program to optimality, we separate the proposed constraints in the branch-and-cut loop of a state-of-the-art ILP solver. Results on natural and biological images demonstrate the effectiveness of the approach as well as its advantage over the state-of-the-art heuristic.
Study of the D 0 p amplitude in Λ b 0  → D 0 pπ − decays (2017)

An amplitude analysis of the decay 0 b D 0 p -is performed in the part of the phase space containing resonances in the D 0 p channel. The study is based on a data sample corresponding to an integrated luminosity of 3.0 fb -1 of pp collisions recorded by the LHCb experiment. The spectrum of excited + c states that decay into D 0 p is studied. The masses, widths and quantum numbers of the c (2880) + and c (2940) + resonances are measured. The constraints on the spin and parity for the c (2940) + state are obtained for the first time. A near-threshold enhancement in the D 0 p amplitude is investigated and found to be consistent with a new resonance, denoted the c (2860) + , of spin 3/2 and positive parity.
Progressive versus constant tapered shaft design using NiTi rotary instruments (2003)

The progressive tapered shaft design of the ProTaper instrument was less influenced by the mid-root curvature than the constant tapered design of the K3 instrument thereby providing a good centred apical preparation. However, ProTaper instruments tended to transport towards the furcation in the coronal region.
Abstract 60: Induction of T cell dysfunction and NK-like T cell differentiation in vitro and in patients after CAR T cell treatment (2021)

Abstract Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable success in hematological malignancies but remains largely ineffective in solid tumors. A major factor leading to the reduced efficacy of CAR T cell therapy is T cell dysfunction, and the mechanisms mediating this dysfunction are under investigation. Here we establish a robust model to study dysfunction of mesothelin-redirected CAR T cells in pancreatic cancer. Continuous antigen exposure results in hallmark features of exhaustion including reduced proliferation capacity and cytotoxicity, and severe defects in cytokine production. Here we identified a transcriptional signature at both population and single-cell levels in CAR T cells after continuous antigen exposure. In addition, TCR lineage tracing revealed a CD8+ T-to-NK-like T cell plasticity that results in reduced tumor cell killing. The transcription factors SOX4 and ID3 are specifically expressed in the dysfunctional CAR NK-like T cells and are predicted to be master regulators of the dysfunction gene expression signature and the post-thymic acquisition of an NK-like T cell fate. Finally, we identified the emergence of NK-like CAR T cells in a subset of patients after infusion of CAR T cells. The findings gleaned from this study shed light on the plasticity of human CAR T cells and suggest new approaches to improve the efficacy of CAR T cell therapy in solid tumors by preventing or revitalizing CAR T cell dysfunction. Citation Format: Charly R. Good, Shunichiro Kuramitsu, Parisa Samareh, Greg Donahue, Kenichi Ishiyama, Yujie Ma, Nils Wellhausen, Lifeng Tian, Sangya Agarwal, Sonia Guedan, M. Angela Aznar, Katherine A. Alexander, Zhen Zhang, Nathan Singh, Max W. Richardson, Keisuke Watanabe, Janos L. Tanyi, Mark H. O'Hara, Marco Ruella, Simon F. Lacey, Edmund K. Moon, Stephen J. Schuster, Steven M. Albelda, Lewis L. Lanier, Regina M. Young, Shelley L. Berger, Carl H. June. Induction of T cell dysfunction and NK-like T cell differentiation in vitro and in patients after CAR T cell treatment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 60.
Adaptive Modulation with Adaptive Pilot Symbol Assisted Estimation and Prediction of Rapidly Fading Channels (2003)

Adaptive modulation requires channel state information (CSI) at both transmitter and receiver. In practice, CSI can be acquired at the receiver by inserting pilot symbols in the transmitted signal. In this paper, we first analyze the effect channel estimation and prediction errors have on bit error rate (BER). Based on this analysis, we develop adaptive pilot symbol assisted modulation (PSAM) schemes that account for both channel estimation and prediction errors to meet the target BER. While pilot symbols facilitate channel acquisition, they consume part of transmitted power and bandwidth, which in turn reduces spectral efficiency. With imperfect (and thus partial) CSI available at the transmitter and receiver, two questions arise naturally: how often should pilot symbols be transmitted? and how much power should be allocated to pilot symbols? We address these two questions by optimizing pilot parameters to maximize spectral efficiency.
Data Analysis and Consideration of Radar-Based Contactless Biometrics Monitoring Testbed for Single Elderly Households (2021)

고령층 1인가구용 헬스케어 서비스를 위해서는 사용자의 생체정보를 인식하고, 그에 맞는 서비스를 제공할 수 있는 환경을 구성해야 한다. 모니터링 방식 중 하나로, 사용자 편의성과 가격 등을 고려하여, 레이더 기반의 비접촉식 생체정보 모니터링 방식이 연구되고 있다. 이번 논문에서는 레이더 기반의 비접촉식 생체정보 모니터링 플랫폼 실증사업을 통해 수집된 51명의 참여자 데이터를 바탕으로 그들의 활동 상태를 예측하는 데이터 분석 연구를 진행하였다. 실증 데이터의 분석을 통해 다양한 특징을 확인하였으며, 잘 알려진 기계학습 분석 방법들을 활용하여 데이터를 기반으로 사용자들의 상태 예측을 진행하였다. 또한, 분석 결과를 바탕으로 레이더 기반 비접촉식 생체정보 수집 장치를 통한 고령층 1인가구 모니터링 환경의 의의와 한계를 고찰하였다.
SAR distributions of non-uniformly coated interstitial applicators for medical hyperthermia and radiometric imaging (1994)

The benefit of hyperthermia as an adjuvant treatment to brachytherapy in the treatment of breast cancer and other accessible tumours has been widely documented [1]. Results obtained by a variety of researchers have been very consistent. A recent review paper shows an improvement in complete response rates from 37% for radiation alone to 63% for combined radiation and hyperthermia treatment [2]. The objective of the hyperthermia treatment is to raise the tumour temperature to 43°–55°C while keeping the temperature of surrounding tissue below 44°C. The elevated temperature impairs many cellular functions and studies indicate that this greatly increases the effectiveness of chemotherapy and radiation treatments.
Ag Ionic Memory Cell Technology for Terabit-Scale High-Density Application (2019)

We demonstrated a cross-point memory array composed of 40nm Ag ionic memory cell with <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\text{sub}-\mu \text{A}$</tex> and selectorless operation and 10-year data retention, making it a promising candidate for terabit-scale high-density memory application. Discontinuous conductive path with large and dense Ag clusters enabled 10-year retention even at sub-μA current with keeping high non-linearity in I-V. We implemented, for the first time, the improved cell into a 40nm cross-point array and demonstrated narrow read distribution which satisfies requirements for reliable array operation.
Introduction to the Special Issue on the ESA's Soil Moisture and Ocean Salinity Mission (SMOS)—Instrument Performance and First Results (2012)

The introductory overview and 27 papers in this special issue present information on instrument performance and first results of the SMOS mission.
Plane-dependent error diffusion on a GPU (2012)

In this paper, we study a plane-dependent technique that reduces dot-on-dot printing in color images, and apply this technique to a GPU-based error diffusion halftoning algorithm. We design image quality metrics to preserve mean color and minimize colorant overlaps. We further use randomized intra-plane error filter weights to break periodic structures. Our GPU implementation achieves a processing speed of 200 MegaPixels/second for RGB color images, and a speedup of 30 - 37x over a multi-threaded implementation on a dual-core CPU. Since the GPU implementation is memory bound, we essentially get the image quality benefits for free by adding arithmetic complexities for inter-plane dependency and error filter weights randomization.
Propagation of Hepatitis B Virus in a Rat Hepatoma Cell Line Stably Transfected with Human Annexin-V (2007)

H B virus (HBV) displays a distinct hepatotropism and a narrow host range in vivo (1, 2). Several studies using transfection and/or transgenic technology have suggested that the species barrier of HBV infection and replication may be located at the early step of viral adsorption (3, 4). However, information is incomplete concerning the interaction of HBV with its host cells, mainly because of difficulties in the development of a suitable tissue culture system. HBV infection in in vitro systems involves chromosomal replication of HBV-DNA but does not include the early events of infection. Transformed cell lines have been used for shortlived, single cycle culture of HBV after infection; however, the cells are thought to lose some of their liver specific functions, leading to loss of susceptibility to HBV. During the last decade, the studies on the putative receptors for HBV have revealed controversial and confusing results. It has been suggested that the HBV pre-S1 domain, in
A new polymorphic probe on chromosome 3p: λLIB09–75′ (D3S584) (1991)

XLIB09 -75' is a 3.8 kb EcoRI fragment isolated from a Charon 21 A human chromosome 3 library (1). Polymorphism: TaqI digestion of genomic DNA and hybridization with the probe detect a two-allele polymorphism: 3.8 kb (Al) and 3.5 kb (A2). Frequency: Estimated from 30 unrelated Caucasians.
ChemInform Abstract: MULTIPLE BONDS BETWEEN MAIN GROUP ELEMENTS AND TRANSITION METALS. PART 8. CHEMISTRY OF THE NEW OXO‐SEMISANDWICH COMPLEX (η5‐C5ME5)REO3: FUNCTIONALIZATION AND AGGREGATION (1984)

Abstract Der aus dem isostrukturellen Tricarbonylkomplex durch Licht‐ und Sauerstoffeinwirkung zugängliche d°‐ReV"‐Titelkomplex (I) reagiert mit AlMe 3 zum kristallinen, oxidationsempfindlichen Re(V)‐Komplex (II).
Failure analysis of advanced CMOS technology: some trends, state of the art and future challenges (2008)

International audience
The nanoscopic lens: new generation applications and future scope (2015)

Mathjax On | Off Abstract Combining the nanoscopic focusing technique with the processes of electrospraying and EPD has manifold advantages over traditional techniques; significant progress has been made in this direction. Some of the possible applications and benefits are listed in the following.
Disruption of Lipid Rafts Induces Gonadotropin Release in Ovine Pituitary and LbetaT2 Gonadotroph Cells1 (2008)

In order to better understand the cellular mechanisms underlying LH and FSH secretion, we have addressed the contribution of lipid rafts to the secretion of gonadotropins. We used methyl-beta-cyclodextrin (MbetaCD), a cholesterol-sequestering agent, on an LbetaT2 murine gonadotroph cell line and on primary cultures of ovine pituitary cells. We found that in both systems, cholesterol depletion by MbetaCD induced a fast and substantial release of LH in the absence of natural stimulation by GnRH. In ovine pituitary cells, MbetaCD-mediated LH release was shown to be independent of protein synthesis. Twenty-four hours after MbetaCD treatment, there was no loss of cell viability and full recovery of LH secretory capabilities, as determined by GnRH or MbetaCD treatment. In addition, our data suggest the existence of a pool of LH that is not released by GnRH treatment but that is released by MbetaCD treatment. Finally, in ovine pituitary cells, MbetaCD treatment induced FSH secretion. Importantly, these in vitro data are supported by in vivo studies, because MbetaCD injected into the pituitary glands of anaesthetized sheep reproducibly induced a peak of LH release.
New Findings on Damage Potential, Geochemical Reaction Mechanisms, and Production Enhancement Applications for Citric Acid (2003)

Abstract Application of citric acid for damage removal in both clastic and carbonate rocks has historically not received widespread acceptance due to formation damage concerns regarding precipitation of calcium citrate. In addition, usage of citric acid in place of hydrochloric acid has been avoided due to lower bulk carbonate dissolving power relative to hydrochloric acid. However, environmental, safety, and corrosion concerns with using hydrochloric acid have sparked renewed interest in citric acid for stimulation. This paper reconsiders the use of citric acid as both an additive to conventional hydrochloric acid systems and as a stand-alone acidizing fluid. The paper reviews extensive laboratory work focused on understanding reaction pathways and geochemical precipitation issues, and takes a new look at paradigms related to the calcium citrate issue. Laboratory studies performed independently by two research laboratories address two main areas of investigation: (1) Evaluation of potential geochemical reaction paths and precipitation of calcium citrate and (2) mechanisms for generation of differential etching in two carbonate rock lithotypes. The described mechanism for etching enhances conductivity in a contrasting mode compared to hydrochloric acid. Findings based on this work provide new insights into the applications, usage and potential limitations of citric acid. A newly proposed process for downhole reaction is presented. This process differs greatly from long-held paradigms built on a foundation of bench-top experimentation. Factors controlling downhole reactions are disclosed and the results of core testing and fracture conductivity are presented.
The Analysis of Complex Socioeconomic Systems. (1976)

Journal Article The Analysis of Complex Socioeconomic Systems Get access The Analysis of Complex Socioeconomic Systems. By P. S. ALBIN. (Lexington, Mass.: D. C. Heath and Company, 1975. Pp. xvii+ 150. £7.00.) N. Stern N. Stern St Catherine's College Oxford Search for other works by this author on: Oxford Academic Google Scholar The Economic Journal, Volume 86, Issue 342, 1 June 1976, Pages 397–399, https://doi.org/10.2307/2230779 Published: 01 June 1976
Waveguiding in silicon photonic crystal slabs - Thrust toward ultradense optical integration (2004)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Y. Vlasov, S. McNab, and N. Moll, "Waveguiding in silicon photonic crystal slabs - Thrust toward ultradense optical integration," in Optical Amplifiers and Their Applications/Integrated Photonics Research, Technical Digest (CD) (Optica Publishing Group, 2004), paper IWB1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Improved disturbance rejection for high precision systems through estimation of the flexible modes (2015)

This paper demonstrates applications of a state observer in high precision control systems that improve low frequency disturbance rejection. By changing the plant transfer function as seen by the feedback controller the effect of flexible modes on the feedback loop is reduced. This allows a redesign of the feedback controller for improved control bandwidth and, consequently, improved low frequency disturbance rejection. Simulation and experimental validation results are presented for the applications to elucidate their (combined) effects.
Frequency Estimator Based on Spectrum Correction and Remainder Sifting for Undersampled Real-Valued Waveforms (2019)

Frequency estimation of undersampled waveforms receives increasing attention in communication, radar signal processing, instrumentation and measurements, and so on. However, due to the lack of recognizing the correct remainder between two side spectra, the existing Chinese Remainder Theorem (CRT)-based frequency estimators can hardly deal with real-valued signals. To achieve this goal, this paper proposes an estimator combining spectrum correction (aiming to enhance reconstruction accuracy by incorporating the fractional parts of DFT remainders), closed-form CRT, and a remainder sifting approach. Based on the detection of an undersampled waveform's zero crossing point, this solution can pick out the correct remainder between two side spectra, which ensures that the CRT achieves a valid reconstruction. Compared with the existing Maroosi-Bizaki estimator, the proposed method not only enlarges the upper bound of frequency recovery but also possesses higher reconstruction accuracy (the relative error is less than 0.002%) with lower consumption of computational complexity. The numerical results verify the superior performances of our estimator.
HYDRATION BEHAVIOR AND FIXATION ABILITY OF CHLORIDE ION BY A VARIETY OF KINDS OF HARDENED CEMENTS ADDED WITH CaO・2Al<sub>2</sub>O<sub>3</sub> (2011)

CaO・2Al2O3を混和した普通、早強及び低熱ポルトランドセメントをそれぞれ水和させると、セメント水和物として、3CaO・Al2O3・Ca（OH）2・12H2Oとモノサルフェートが多量に生成した。生成した水和物が異なったのはセメント中のAl2O3量とSO3量が異なるためであると考察した。CaO・2Al2O3を混和し、水和させた各種セメント硬化体を塩水に浸漬すると、塩化物イオン浸透深さが減少し、表層部の塩化物イオン濃度が高くなった。これは、フリーデル氏塩の生成による塩化物イオン固定化の化学的な作用により、塩化物イオンの浸透が抑制されたと考察した。その効果は特に低熱セメントにおいて顕著であった。
Chapter 3. NDI Foldamers, Assemblies and Conformational Switching (2017)

Naphthalene tetracarboxylic diimide (NDI) has been used in a number of ways to create folding and assembling supramolecular systems. A brief summary of interactions between aromatic units is presented with an emphasis on using electrostatic principles to predict interaction geometries. As a consequence of the highly polarized carbonyl groups on its periphery, NDI has a propensity to self-stack in a characteristic off-set parallel fashion, while preferring an alternating face-centered stacking geometry with complementary, electron rich aromatic moieties such as dialkoxyl naphthalene (DAN) units. This ability to shift between self-stacking and alternating stacking with electron-rich units is now the basis for a growing list of NDI-based supramolecular complexes and assemblies that can undergo predictable conformational switching.
Pelvic Injury Survival Analysis for a Finite Element Human Body Model Using Multiple Data Sets (2018)

Finite element (FE) computational human body models (HBMs) have gained popularity over the past several decades as human surrogates for use in blunt injury research. FE HBMs are critical for the analysis of local injury mechanisms. These metrics are challenging to measure experimentally and demonstrate an important advantage of HBMs. The objective of this study is to evaluate the injury risk predictive power of localized metrics to predict the risk of pelvic fracture in a FE HBM. The Global Human Body Models Consortium (GHBMC) 50th percentile detailed male model (v4.3) was used for this study. Cross-sectional and cortical bone surface instrumentation was implemented in the GHBMC pelvis. Lateral impact FE simulations were performed using input data from tests performed on post mortem human subjects (PMHS). Predictive power of the FE force and strain outputs on localized fracture risk was evaluated using the receiver operator characteristic (ROC) curve analysis. The ROC curve analysis showed moderate predictive power for the superior pubic ramus and sacrum. Additionally, cross-sectional force was compared to a range of percentile outputs of maximum principal, minimum principal, and effective cortical element strains. From this analysis it was determined that cross-sectional force was the best predictor of localized pelvic fracture.