gebhart/patrepeval huggingface dataset:
Foot-and-Mouth Disease Seroprevalence in Cattle in Eritrea (2015)

Information about seroprevalence of foot-and-mouth disease (FMD) and virus serotypes in Eritrea is unavailable, but is very important as it may guide the choice of intervention measures including vaccination to be implemented. We carried out a cross-sectional study from February to June 2011 in Eritrea with a two-stage cluster design, sampling cattle in 155 villages with the objective of determining the seroprevalence of FMD in four administrative regions of the country. We analysed cattle sera (n = 2429) for FMD virus antibodies using the non-structural ELISA (NS ELISA) and virus neutralization test (VNT). The overall seroprevalence was 26% and 30% for the NS ELISA and VNT, respectively. FMD virus serotypes O (14%) and A (11%) were the most prevalent. Gash Barka showed the highest (39%) seroprevalence both in NS ELISA and VNT compared to the other three administrative regions. Strategic FMD virus vaccination with type O and A (matching circulating strains) in combination of zoo-sanitary measures would be the best control option for Eritrea which could be started in areas where the disease is less endemic.
Signaling Diversity in Human Lymphoma B Cells and in Tumor Infiltrating T Cells Correlates with Follicular Lymphoma Patient Clinical Outcomes (2008)

Abstract Introduction: Flow cytometry analysis of live cells from cryopreserved tumor samples provides the opportunity to study simultaneously the biology of both cancer cells and the patient’s immune system cells. Furthermore, single cell based approaches can identify and quantify subsets within mixed populations, such as heterogeneous primary tumors, without the need to physically separate cells. We have previously used flow cytometry to identify differences in signaling mechanism between healthy human B cells from two differentiation stages and to compare signaling kinetics of tumor and non-malignant B cells within primary human lymphoma specimens1. Methods: Here we used barcoded phospho-specific flow cytometry to measure signaling events in live lymphoma B cells and tumor-infiltrating T cells from follicular lymphoma (FL) tumor samples obtained before patients received therapy. Patients were then stratified according to signaling and clinical outcome was examined within the resulting groups. We examined response to initial chemotherapy, which was a combination of cyclophosphamide, vincristine, and prednisone (cvp), and overall survival, measured as the time from diagnosis to last follow up or mortality. Results: Differences in B cell receptor (BCR) signaling strength and kinetics characterized previously unappreciated diversity within the lymphoma B cell population. In some cases, BCR crosslinking triggered robust phosphorylation of AKT and ERK in one subset of lymphoma cells, while in another lymphoma subset within the same tumor sample, BCR crosslinking did not lead to phosphorylation of either protein. In these cases, both lymphoma B cell subsets expressed BCL2 and surface immunoglobulin heavy and light chain restricted to the tumor isotype. Patients whose lymphoma tumor contained a BCR insensitive cell subset (Group 2) had significantly worse responses to cvp therapy (p = 0.001) and lower overall survival (p = 0.003) than patients whose lymphoma cells displayed more homogeneous BCR signaling (Group 1). We next examined tumor infiltrating T cell signaling in the FL cases from Group 1, where no significant BCR insensitive subset was observed. Within Group 1, differences in the magnitude of IL-2, IL-7, and IL-15 mediated STAT5 phosphorylation in tumor infiltrating T cells further distinguished a set of patients with significantly higher overall survival (p = 0.04). Conclusions: These results identify BCR signaling in lymphoma B cells and cytokine signaling in tumor infiltrating T cells as clinically relevant biomarkers for tracking and isolating lymphoma cell subsets and for monitoring immune system activity during therapy. By following patients over time, we can now determine whether cell intrinsic signaling diversity enables the emergence of therapy insensitive cancer cell subsets.
Field inversion and point halving revisited (2004)

We present a careful analysis of elliptic curve point multiplication methods that use the point halving technique of Knudsen and Schroeppel and compare these methods to traditional algorithms that use point doubling. The performance advantage of halving methods is clearest in the case of point multiplication kP, where P is not known in advance and smaller field inversion to multiplication ratios generally favor halving. Although halving essentially operates on affine coordinate representations, we adapt an algorithm of Knuth to allow efficient use of projective coordinates with halving-based windowing methods for point multiplication.
Ursodeoxycholyl-Lysophosphatidylethanolamid (UDCA-LPE) inhibiert TNFα-vermittelte Apoptose und Inflammation in Leberzellen durch Reduktion von Lysophoshatidylcholin und Inhibition pro-inflammatorischer Signalwege (2009)

Einleitung: Störungen der Phospholipid-Homeostase können zum Zelltod führen und sind mit der Pathogenese verschiedener Lebererkrankungen assoziiert. In der vorliegenden Arbeit wurde das neu entwickelte Gallensäure-Phospholipid-Konjugat UDCA-LPE in Hinblick auf anti-apoptotische und anti-inflammatorische Wirkung, sowie dessen Einfluss auf die Phospholipidkomposition nicht-transformierter Leberzellen untersucht.
Efficient ray tracing for path loss prediction in urban canyon environment (2008)

In this paper, we propose an efficient ray tracing method based on a 4-ray model considering a real urban canyon environment characterized by building distributions. In order to reduce the computing time, reduce the complexity of the ray tracing algorithm, and easily apply the method to an existing GIS containing building information, the relationship between the 4-ray model and a roadside building width index (BWI) relating to the building distribution information around the received signal is considered. The modified 4-ray model can efficiently estimate propagation characteristics, including path loss and fading, in an urban canyon environment.
Behavior of ordered sodium in enzymatically depleted cartilage tissue (2006)

The onset of cartilage tissue disorders can be characterized by a loss of proteoglycans (PGs) and diagnosed by contrast-enhanced proton ((1)H) MRI techniques, as well as sodium MRI. The behavior of sodium located in anisotropic environments, is examined as a function of cartilage degeneration. PGs are proteolytically depleted from the cartilage samples, which gives rise to a decrease of the ordered sodium content. More surprisingly, however, the residual quadrupolar couplings are shown to increase with increasing depletion levels. Since the residual quadrupolar couplings are intimately related to local order and anisotropic motion, measuring their distribution in cartilage may provide insight into the structural changes that occur within the tissue upon degradation. In this study relatively mild orientational dependence of the couplings was found. Little or no free sodium was observed in the cartilage specimens under study.
Polylithic integration of electrical and optical interconnect technologies for gigascale fiber-to-the-chip communication (2005)

Polylithic integration of electrical and optical interconnect technologies is presented as a solution for merging silicon CMOS and compound semiconductor optoelectronics. In contrast to monolithic and hybrid integration technologies, polylithic integration allows for the elimination of optoelectronic and integrated optic device-related processing from silicon CMOS manufacturing. Printed wiring board-level and compound semiconductor chip-level waveguides terminated with volume grating couplers facilitate bidirectional optical communication, where fiber-to-board and board-to-chip optical coupling occurs through a two-grating (or grating-to-grating) coupling path. A 27% increase in the electrical signal I/O projected by and 33% increase in the number of substrate-level electrical signal interconnect layers implied by the International Technology Roadmap for Semiconductors (ITRS) projections for the 32-nm technology generation are required to facilitate 10 Tb/s aggregate bidirectional fiber-to-the-chip communication. Buried air-gap channels provide for the routing of chip or board-level encapsulated air-clad waveguides for minimum crosstalk and maximum interconnect density. Optical signals routed on-board communicate with on-chip volume grating couplers embedded as part of a wafer-level batch package technology exhibiting compatible electrical and optical input/output interconnects. Measurements of grating-to-grating coupling reveal 31% coupling efficiency between two slab, nonoptimized, nonfocusing volume grating couplers.
N-[4-(1H-Pyrazolo[3,4-B]pyrazin-6yl)-phenyl]-sulonamides and Their Use As Pharmaceuticals (2013)

ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXTN-[4-(1H-Pyrazolo[3,4-B]pyrazin-6yl)-phenyl]-sulonamides and Their Use As PharmaceuticalsBenjamin Blass*View Author Information Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, United States*Tel: 215-707-1085. E-mail: [email protected]Cite this: ACS Med. Chem. Lett. 2013, 4, 11, 1022–1024Publication Date (Web):October 11, 2013Publication History Received29 September 2013Published online11 October 2013Published inissue 14 November 2013https://pubs.acs.org/doi/10.1021/ml400389ahttps://doi.org/10.1021/ml400389aeditorialACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views621Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (311 KB) Get e-AlertscloseSUBJECTS:Hydrogen,Nitrogen,Peptides and proteins,Phenyls,Substituents Get e-Alerts
New results on reconstruction of continuous-tone from halftone (1992)

Two iterative methods are used to reconstruct a continuous-tone image from its halftone: successive approximation and projection onto convex sets. The halftone image is assumed to be generated by thresholding with an unknown screen function which is estimated from the halftone image in the first stage of the reconstruction process. The screen function is an integral part of both iterative reconstruction methods. The other key element is a constraint on the bandwidth of the reconstructed image. Relaxing this constraint during the course of the iterations not only reduces the RMS error after each iteration but also achieves a relatively sharp full-band reconstruction at the end.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Principles of Polymer Systems (2003)

The Fifth Edition of Principles of Polymer Systems has been completely revised and updated. The chemical engineering perspective has been retained and strengthened, and the broad applications of polymers in chemistry and materials science have been addressed. The theoretical basis for various topics has been deepened and strengthened and several ne
Effect of cutting parameters on materials swelling of machined surfaces in single-point diamond turning (2005)

3rd International Conference on Leading Edge Manufacturing in 21st Century, LEM 2005, Nagoya, 19-22 October 2005
Effectiveness-weighted control of cooling system components (2023)

Energy efficient control of cooling system cooling of an electronic system is provided based, in part, on weighted cooling effectiveness of the components. The control includes automatically determining speed control settings for multiple adjustable cooling components of the cooling system. The automatically determining is based, at least in part, on weighted cooling effectiveness of the components of the cooling system, and the determining operates to limit power consumption of at least the cooling system, while ensuring that a target temperature associated with at least one of the cooling system or the electronic system is within a desired range by provisioning, based on the weighted cooling effectiveness, a desired target temperature change among the multiple adjustable cooling components of the cooling system. The provisioning includes provisioning applied power to the multiple adjustable cooling components via, at least in part, the determined control settings.
Hierarchical Assembly of Atomically Precise Metal Clusters as a Luminescent Strain Sensor (2021)

We demonstrate the formation of a versatile luminescent organo-inorganic layered hybrid material, composed of bovine serum albumin (BSA)-protected Au<sub>30</sub> clusters and aminoclay sheets. X-ray diffraction revealed the intercalation of Au<sub>30</sub>@BSA in the layered superstructure of aminoclay sheets. Coulombic attraction of the clusters and the clay initiates the interaction, and the appropriate size of the clusters allowed them to intercalate within the lamellar aminoclay galleries. Electron microscopy measurements confirmed the hierarchical structure of the material and also showed the cluster-attached clay sheets. Zeta potential measurement and dynamic light scattering probed the gradual formation of the ordered aggregates in solution. The hybrid material could be stretched up to 300% without fracture. The emergence of a new peak in the luminescence spectrum was observed during the course of mechanical stretching. This peak increased in intensity gradually with the degree of elongation or strain of the material. A mechanochromic luminescence response was further demonstrated with a writing experiment on a luminescent mat of the material, made by electrospinning.
Characterization of a newly established human bone marrow endothelial cell line: distinct adhesive properties for hematopoietic progenitors compared with human umbilical vein endothelial cells. (1997)

Human bone marrow endothelial cells (HBMEC) are intimately involved in the homing of hematopoietic progenitor cells (HPC) to the bone marrow and in the regulation of proliferation and differentiation of these cells. Because availability of primary HBMEC and their capacity to be cultured in vitro are limited, we used isolated HBMEC to establish a cloned cell line by microinjection of a recombinant plasmid expressing simian virus 40 early genes under the control of a deletion mutant of the human vimentin promoter. Serum requirements for growth of a transformed HBMEC line (TrHBMEC) were markedly decreased compared with those of primary cells, and added growth factors were not required for proliferation. Cells took up acetylated low-density lipoprotein normally, bound to Ulex europaeus lectin, and stained positively for von Willebrand factor, P-selectin, CD31, CD34, CD44, very late antigen-5, and intercellular adhesion molecule-2 (ICAM-2). After treatment with TNF-alpha or lipopolysaccharide, TrHBMEC increased surface expression of E-selectin, vascular cell adhesion molecule-1 (VCAM-1), and ICAM-1 in a manner similar to primary HBMEC. In contrast, IL-1 beta elicited much less up-regulation of these adhesion molecules than in primary cells. In previous work, we reported that, in a flow adhesion model, rolling of peripheral blood CD34+ cells on primary HBMEC was E-selectin-dependent, whereas VCAM-1 and ICAM-1 contributed to firm adhesion. In the present study, we show that HPC adhere in a similar way to TrHBMEC. A less-pronounced role for VCAM-1 and ICAM-1 was found in the adhesion of HPC to human umbilical vein endothelial cells. Furthermore, significantly more CD34+ cells adhered to TNF-alpha-stimulated HBMEC and TrHBMEC than to similarly stimulated human umbilical vein endothelial cells. These data emphasize the importance of using microvessel HBMEC for studying the homing of HPC to the bone marrow, and indicate the usefulness of the above-described bone marrow endothelial cell line.
Homozygous C4A deficiency in systemic lupus erythematosus: analysis of patients from a defined population (1990)

Homozygous C4A deficiency was found at a prevalence of 16% (13/80 patients) in systemic lupus erythematosus (SLE). The patients represented all diagnosed cases retrieved from a defined population in Southern Sweden, which minimizes the influence of patient selection. Photosensitivity was more common among C4A-deficient patients than among other SLE patients (p less than 0.05). Otherwise, clinical features were similar in the two groups. In addition, no differences were found with regard to presence of various autoantibodies (anti-dsDNA, anti-Sm, anti-RNP, anti-SSA, anti-SSB, rheumatoid factors and anti-cardiolipin). In patients expressing both C4A and C4B isotypes, C4B/C4A quotients were fairly stable in plasma irrespective of disease activity. This argues against preferential break-down of either isotype during complement activation in the disease. The increased photosensitivity of C4A-deficient patients partly resembles the findings in patients with complete deficiencies of classical pathway components.
Survival with competing risks and masked causes of failures (1998)

Journal Article Survival with competing risks and masked causes of failures Get access BETTY J. FLEHTNGER, BETTY J. FLEHTNGER Mathematical Sciences Department, IBM Research Division, T. J. Watson Research Center, Yorktown HeightsNew York 10598, U.S.A.aisen@watson.ibm.comrsst305@uvm.haifa.ac.ilyashchi@watsonibm.com Search for other works by this author on: Oxford Academic Google Scholar BENJAMIN REISER, BENJAMIN REISER Mathematical Sciences Department, IBM Research Division, T. J. Watson Research Center, Yorktown HeightsNew York 10598, U.S.A.aisen@watson.ibm.comrsst305@uvm.haifa.ac.ilyashchi@watsonibm.com Search for other works by this author on: Oxford Academic Google Scholar EMMANUEL YASHCHIN EMMANUEL YASHCHIN Mathematical Sciences Department, IBM Research Division, T. J. Watson Research Center, Yorktown HeightsNew York 10598, U.S.A.aisen@watson.ibm.comrsst305@uvm.haifa.ac.ilyashchi@watsonibm.com Search for other works by this author on: Oxford Academic Google Scholar Biometrika, Volume 85, Issue 1, March 1998, Pages 151–164, https://doi.org/10.1093/biomet/85.1.151 Published: 01 March 1998 Article history Received: 01 April 1996 Revision received: 01 July 1997 Published: 01 March 1998
Basin-scale tomography: A new tool for studying weather and climate (1990)

Measurements of acoustic travel time across the northeast Pacific Ocean are used to detect large-scale (&amp;gt;500 km) thermal trends in the ocean interior. The trends are novel observations, and there is probably no method to verify them with other data sets. The results demonstrate the practicality of a new and powerful means to observe ocean temperature and to investigate its relation to weather, climate, and greenhouse warming.
Cryospectroscopy of intermediates in the mechanism of carboxypeptidase A (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCryospectroscopy of intermediates in the mechanism of carboxypeptidase AKieran F. Geoghegan, Alphonse Galdes, Richard A. Martinelli, Barton Holmquist, David S. Auld, and Bert L. ValleeCite this: Biochemistry 1983, 22, 9, 2255–2262Publication Date (Print):April 26, 1983Publication History Published online1 May 2002Published inissue 26 April 1983https://pubs.acs.org/doi/10.1021/bi00278a031https://doi.org/10.1021/bi00278a031research-articleACS PublicationsRequest reuse permissionsArticle Views51Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermoplastic Vulcanizates Based on Highly Compatible Blends of Isotactic Poly(propylene) and Copolymers of Atactic Poly(propylene) and 5‐Ethylidene‐2‐norbornene (2009)

Abstract Highly compatible thermoplastic/elastomer blends were used to prepare thermoplastic vulcanizates (TPVs) with refined morphologies and improved mechanical properties. Copolymers of atactic poly(propylene) (aPP) and 5‐ethylidene‐2‐norbornene (ENB) (aPP‐ co ‐ENB) were prepared via metallocene catalysis. Blends of isotactic poly(propylene) (iPP) and the aPP‐ co ‐ENB rubbers are immiscible in the melt, but the very high compatibility leads to a refinement of the morphology in comparison to blends based on iPP and ethylene‐propylene‐ diene (EPDM) rubber. The aPP‐ co ‐ENB‐based blends show improved tensile properties, while the relatively high T g of the rubber phase retards the elastic recovery at room temperature. Dilution of the TPVs with oil broadens the temperature window for applications by a signification reduction of the T g and improves the elasticity of the TPVs. This study demonstrates that the lower limit of the rubber particle size of TPVs that is attainable via dynamic vulcanization of immiscible blends is in the order of 300–500 nm. magnified image
Endosonographisch gestützte Coil-Applikation vs. Cyanoacrylat-Injektion zur Therapie von Fundusvarizen - eine multizentrische Studie (2013)

Einleitung: Die Therapie von Fundusvarizen (GV) stellt noch immer eine technische Herausforderung dar. Für die Therapie von blutenden GV wird die Injektion von Cyanoacrylat (CYA) empfohlen. Diese Therapieform birgt eine signifikante Komplikationsrate, die möglicherweise durch den Einsatz der Endosonografie reduziert werden könnte. Zusätzlich könnte eine endosonographisch gesteuerte Coil-Applikation (ECA) eine therapeutische Alternative darstellen.