gebhart/patrepeval huggingface dataset:
Deep Learning for Interference Identification: Band, Training SNR, and Sample Selection (2019)

We study the problem of interference source identification, through the lens of recognizing one of 15 different channels that belong to 3 different wireless technologies: Bluetooth, Zigbee, and WiFi. We employ deep learning algorithms trained on received samples taken from a 10 MHz band in the 2.4 GHz ISM Band. We obtain a classification accuracy of around 89.5% using any of four different deep neural network architectures: CNN, ResNet, CLDNN, and LSTM, which demonstrate the generality of the effectiveness of deep learning at the considered task. Interestingly, our proposed CNN architecture requires approximately 60% of the training time required by the state of the art while achieving slightly larger classification accuracy. We then focus on the CNN architecture and further optimize its training time while incurring minimal loss in classification accuracy using three different approaches: 1- Band Selection, where we only use samples belonging to the lower and uppermost 2 MHz bands, 2- SNR Selection, where we only use training samples belonging to a single SNR value, and 3- Sample Selection, where we try various sub-Nyquist sampling methods to select the subset of samples most relevant to the classification task. Our results confirm the feasibility of fast deep learning for wireless interference identification, by showing that the training time can be reduced by as much as 30x with minimal loss in accuracy.
Linear Flow and Deformation in a Poroelastic Disk With a Free Surface (1994)

The equilibration of an axisymmetric, linearly poroelastic layer of finite thickness is determined given an immobile, impermeable base and an impermeable, stress-free top surface. Analytical and numerical studies show that there are eigenfunctions corresponding to sites of fluid injection and removal. Numerical studies also show that an increase in effective stiffness accelerates the equilibration of initial disturbances with longer wavelengths. A Gaussian initial displacement is shown to spread radially rather than simply decaying in amplitude.
Data from A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas (2023)

&lt;div&gt;Abstract&lt;p&gt;Systematic identification of signaling pathways required for the fitness of cancer cells will facilitate the development of new cancer therapies. We used gene essentiality measurements in 1,086 cancer cell lines to identify selective coessentiality modules and found that a ubiquitin ligase complex composed of &lt;i&gt;UBA6&lt;/i&gt;, &lt;i&gt;BIRC6&lt;/i&gt;, &lt;i&gt;KCMF1&lt;/i&gt;, and &lt;i&gt;UBR4&lt;/i&gt; is required for the survival of a subset of epithelial tumors that exhibit a high degree of aneuploidy. Suppressing BIRC6 in cell lines that are dependent on this complex led to a substantial reduction in cell fitness &lt;i&gt;in vitro&lt;/i&gt; and potent tumor regression &lt;i&gt;in vivo&lt;/i&gt;. Mechanistically, BIRC6 suppression resulted in selective activation of the integrated stress response (ISR) by stabilization of the heme-regulated inhibitor, a direct ubiquitination target of the UBA6/BIRC6/KCMF1/UBR4 complex. These observations uncover a novel ubiquitination cascade that regulates ISR and highlight the potential of ISR activation as a new therapeutic strategy.&lt;/p&gt;Significance:&lt;p&gt;We describe the identification of a heretofore unrecognized ubiquitin ligase complex that prevents the aberrant activation of the ISR in a subset of cancer cells. This provides a novel insight on the regulation of ISR and exposes a therapeutic opportunity to selectively eliminate these cancer cells.&lt;/p&gt;&lt;p&gt;&lt;i&gt;&lt;a href="https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-22-1440" target="_blank"&gt;See related commentary Leli and Koumenis, p. 535&lt;/a&gt;.&lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;a href="https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-13-3-ITI" target="_blank"&gt;This article is highlighted in the In This Issue feature, p. 517&lt;/a&gt;&lt;/p&gt;&lt;/div&gt;
Development of flow cytometry assays for measuring cell-membrane enzyme activity on individual cells (2019)

<b>Background:</b> Cell-membrane expressing enzymes such as ADAM (a disintegrin and metalloproteinase) superfamily members are thought to be key catalysts of vital cellular functions. To directly measure these enzymes and determine their association with particular cells and functions, individual-cell membrane-bound enzyme activity assays are required, but unavailable. <b>Methods:</b> We developed two such assays, using a fluorescence resonance energy transfer (FRET) peptide substrate (FPS) and flow cytometry. One assay measured live-cell natural processing of FPS and binding of its fluorescent product onto individual-cell membrane-bound enzymes. The other assay measured processing of specifically-bound and glutaraldehyde-crosslinked FPS, and consequent generation of its coupled fluorescent product onto individual-cell membrane-bound enzymes. <b>Results:</b> Confocal-microscopy imaging indicated that proteolytic processing of FPS selectively occurred on and labeled cell membrane of individual cells. The new assays measured specific increases of cell-associated FPS fluorescent product in substrate-concentration-, temperature- and time-dependent manners. A large proportion of processed FPS fluorescent products remained cell-associated after cell washing, indicating their binding to cell-membrane expressing enzymes. The assays measured higher levels of cell-associated FPS fluorescent product on wild-type than ADAM10-knockout mouse fibroblasts and on human monocytes than lymphocytes, which correlated with ADAM10 presence and expression levels on cell membrane, respectively. Furthermore, the enzyme activity assays could be combined with fluorescent anti-ADAM10 antibody staining to co-label and more directly associate enzyme activity and ADAM10 protein levels on cell membrane of individual cells. <b>Conclusions:</b> We report on two novel assays for measuring cell-membrane anchored enzyme activity on individual cells, and their potential use to directly study specific biology of cell-surface-expressing proteases.
Renal Duplex Doppler Ultrasound: An Adjunct in the Evaluation of Hydronephrosis in the Child (1993)

We used renal duplex Doppler ultrasound to evaluate 28 hydronephrotic pediatric kidneys. A total of 28 normal renal units was used as controls. Renal Doppler ultrasound findings were compared with drainage values obtained with renal scintigraphic diuretic renography, and demonstrated close correlation. In control units significantly different resistive index values were noted between patients 0 to 12 months old and those older than 1 year. The younger group had average resistive indexes of 0.66, while the older group had an average value of 0.57 (p < 0.001). In hydronephrotic kidneys resistive index values were significantly higher (0.83) in renal units with obstructive T1/2 values on diuretic renography compared to those with indeterminate or nonobstructive T1/2 values (0.63) (p < 0.001). Renal Doppler ultrasound correlates closely with diuretic renography in hydronephrotic systems in infants and in older children. Additionally, it provides an early, noninvasive modality of assessing the dilated upper tract in infants and older children. Therefore, renal Doppler ultrasound is a reliable adjunct in identifying obstructed renal units.
Transport Properties of a High Molecular Weight Poly(propylene oxide)‐ LiCF3 SO 3 System (1999)

Conductivities (σ), salt diffusion coefficients <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="ML1" overflow="scroll"> <mml:mo stretchy="false">(</mml:mo> <mml:msub> <mml:mi>D</mml:mi> <mml:mrow> <mml:mi mathvariant="normal">s</mml:mi> </mml:mrow> </mml:msub> <mml:mo stretchy="false">)</mml:mo> </mml:math> , and cationic transference numbers <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="ML2" overflow="scroll"> <mml:mo stretchy="false">(</mml:mo> <mml:msubsup> <mml:mi>t</mml:mi> <mml:mrow> <mml:mo>+</mml:mo> </mml:mrow> <mml:mrow> <mml:mn>0</mml:mn> </mml:mrow> </mml:msubsup> <mml:mo stretchy="false">)</mml:mo> </mml:math> are reported for a high molecular weight polypropylene oxide <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="ML3" overflow="scroll"> <mml:mo stretchy="false">(</mml:mo> <mml:mi mathvariant="normal">Parel</mml:mi> <mml:mo>™</mml:mo> <mml:mo>‐</mml:mo> <mml:msub> <mml:mi mathvariant="normal">LiCF</mml:mi> <mml:mrow> <mml:mn>3</mml:mn> </mml:mrow> </mml:msub> <mml:msub> <mml:mo>SO</mml:mo> <mml:mrow> <mml:mn>3</mml:mn> </mml:mrow> </mml:msub> <mml:mo stretchy="false">)</mml:mo> </mml:math> polymer electrolyte system at 85°C. Transference numbers were determined as a function of salt concentration using a recently described electrochemical method based on concentrated solution theory. For the Parel‐ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="ML4" overflow="scroll"> <mml:msub> <mml:mi mathvariant="normal">LiCF</mml:mi> <mml:mrow> <mml:mn>3</mml:mn> </mml:mrow> </mml:msub> <mml:msub> <mml:mo>SO</mml:mo> <mml:mrow> <mml:mn>3</mml:mn> </mml:mrow> </mml:msub> </mml:math> system, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="ML5" overflow="scroll"> <mml:msubsup> <mml:mi>t</mml:mi> <mml:mrow> <mml:mo>+</mml:mo> </mml:mrow> <mml:mrow> <mml:mn>0</mml:mn> </mml:mrow> </mml:msubsup> </mml:math> is slightly positive for electrolytes with O:Li ratios of 15 or 12:1 but decreases to negative values for more concentrated solutions. This implies that negatively charged ionic aggregates such as triplets are more mobile than free cations in this concentration range. Such behavior is commonly seen in binary salt/polymer electrolytes, which typically exhibit a high degree of nonideality. The nonunity transference numbers and microphase separation in the Parel‐ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="ML6" overflow="scroll"> <mml:msub> <mml:mi mathvariant="normal">LiCF</mml:mi> <mml:mrow> <mml:mn>3</mml:mn> </mml:mrow> </mml:msub> <mml:msub> <mml:mo>SO</mml:mo> <mml:mrow> <mml:mn>3</mml:mn> </mml:mrow> </mml:msub> </mml:math> system strongly suggest that salt precipitation or phase separation in operating cells containing these electrolytes due to the development of large concentration gradients during passage of current. © 1999 The Electrochemical Society. All rights reserved.
Interference mitigation in femtocell networks with joint channel sensing and resource allocation (2015)

Joint channel sensing and resource allocation in femtocell networks is investigated. An approach consisting of using jointly a sensing module in addition to a normal femto module performing resource allocation simultaneously with channel sensing is proposed. The sensed interference levels are used to define an interference transformation function that prioritizes the allocation of subcarriers based on the level of interference they are subjected to. Then, a resource allocation algorithm based on using interference transformation functions is presented. By incorporating interference information in a transformed channel gain, it permits the allocation of subcarriers subjected to little or no interference with high priority, and unfavors the allocation of the more interfered subcarriers. Simulation results show significant performance improvement when the proposed method is implemented.
The impact of the burst assembly interval on the OBS ingress traffic characteristics and system performance (2004)

This paper addresses the burstification interval scaling problem when the timer-based burstification mechanisms, including the periodic and the nonperiodic alternatives, are employed. We investigate the impact of the burstification interval on the burst traffic characteristics in terms of the data burst inter-arrival time and the data burst length, respectively. An analytical model is developed to evaluate the burst delay at the edge node of the OBS-enabled WDM backbone. Numerical and simulation results have justified our analysis.
Carbon−Hydrogen Bond Activation and Cyclodehydrogenation Reactions of Cyclic C8 Hydrocarbons on Pt(111) (1998)

The mechanisms of the thermolytic decomposition of a series of unsaturated cyclic C8 hydrocarbons adsorbed on a platinum(111) single crystal surface are described. This study both confirms and extends the results reported by Frei and Campbell which corrected errors in an earlier report from our laboratory on the mechanisms of thermal decomposition seen in this adsorbate system. We find that the dehydrocyclization of cyclooctene, cyclooctadiene (1,3 and 1,5 isomers), and cyclooctatetraene on Pt(111) proceeds through a related set of intermediates and ultimately yields a novel surface-bound bicyclic ring system. As noted by Frei et al., our earlier finding that benzene is produced in high yield is incorrect. The spectroscopic evidence reported here demonstrates that all four of the cyclic C8 hydrocarbons form a bicyclo[3.3.0]octenyl (or, as more commonly named, a pentalenyl) intermediate of stoichiometry C8H6. This bicyclic ring system forms via a dehydrocyclization of cyclooctatetraene, which itself is formed in varying yields from each of the less-unsaturated c-C8 adsorbates. The formation of the pentalenyl species proceeds at low temperatures (<375 K). Data from reflection−absorption infrared (RAIRS) and temperature-programmed reaction spectroscopies show that the pentalenyl intermediate is remarkably stable, persisting on the surface up to at least 450 K. At temperatures above 450 K, this intermediate fragments, liberating hydrogen, and leaving a carbonaceous overlayer. The formation of cyclooctatetraene, and thus the pentalenyl intermediate, proceeds with the highest efficiency for the two dienes and lowest for cyclooctane and cis-cyclooctene. RAIRS data further serve to identify several intermediates formed along the reaction pathway leading to the platinum-bound C8H6 species.
SARS-CoV-2 subgenomic RNA kinetics in longitudinal clinical samples (2021)

Abstract Background Given the persistence of viral RNA in clinically recovered COVID-19 patients, subgenomic RNAs (sgRNA) have been reported as potential molecular viability markers for SARS-CoV-2. However, few data are available on their longitudinal kinetics, compared with genomic RNA (gRNA), in clinical samples. Methods We analyzed 536 samples from 205 patients with COVID-19 from placebo-controlled, outpatient trials of Peginterferon Lambda-1a (Lambda; n=177) and favipiravir (n=359). Nasal swabs were collected at three time points in the Lambda (Day 1, 4 and 6) and favipiravir (Day 1, 5, and 10) trials. N-gene gRNA and sgRNA were quantified by RT-qPCR. To investigate the decay kinetics in vitro , we measured gRNA and sgRNA in A549 ACE2+ cells infected with SARS-CoV-2, following treatment with remdesivir or DMSO control. Results At six days in the Lambda trial and ten days in the favipiravir trial, sgRNA remained detectable in 51.6% (32/62) and 49.5% (51/106) of the samples, respectively. Cycle threshold (Ct) values for gRNA and sgRNA were highly linearly correlated (Pearson’s r=0.87) and the rate of increase did not differ significantly in Lambda (1.36 cycles/day vs 1.36 cycles/day; p = 0.97) or favipiravir (1.03 cycles/day vs 0.94 cycles/day; p=0.26) trials. From samples collected 15-21 days after symptom onset, sgRNA was detectable in 48.1% (40/83) of participants. In SARS-CoV-2 infected A549 ACE2+ cells treated with remdesivir, the rate of Ct increase did not differ between gRNA and sgRNA. Conclusions In clinical samples and in vitro , sgRNA was highly correlated with gRNA and did not demonstrate different decay patterns to support its application as a viability marker. Summary We observed prolonged detection of subgenomic RNA in nasal swabs and equivalent decay rates to genomic RNA in both longitudinal nasal swabs and in remdesivir-treated A549 ACE2+ cells infected with SARS-CoV-2. Taken together, these findings suggest that subgenomic RNA from SARS-CoV-2 is comparably stable to genomic RNA and that its detection is therefore not a more reliable indicator of replicating virus.
NaIO4/LiBr-mediated Diastereoselective Dihydroxylation of Olefins:  A Catalytic Approach to the Prevost−Woodward Reaction (2005)

[reaction: see text] LiBr catalyzes efficiently the dihydroxylation of alkenes to afford syn and anti diols with excellent diastereoselectivity depending upon the use of NaIO(4) (30 mol %) or PhI(OAc)(2) (1 equiv), respectively, as the oxidants. The oxidation of non-benzylic halides has been achieved for the first time to afford the corresponding diols in excellent yields.
Slow Light in Quantum Dot Semiconductor Laser for Photonic RF Phase Shifter (2007)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text P. C. Peng, J. N. Liu, C. T. Lin, H. C. Kuo, J. H. Chen, S. C. Wang, S. Chi, and J. Y. Chi, "Slow Light in Quantum Dot Semiconductor Laser for Photonic RF Phase Shifter," in Integrated Photonics and Nanophotonics Research and Applications / Slow and Fast Light, OSA Technical Digest (CD) (Optica Publishing Group, 2007), paper JTuA1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Improvement of Mouth Functional Disability in Systemic Sclerosis Patients over One Year in a Trial of Fat Transplantation versus Adipose‐Derived Stromal Cells (2016)

Background. Systemic sclerosis (SSc) is a multisystem disease characterized by cutaneous and visceral fibrosis. Face and mouth changes include telangiectasia, sicca syndrome, and thinning and reduction of mouth width (microcheilia) and opening (microstomia). We applied autologous fat transplantation compared with autologous adipose-derived stromal cells (ADSCs) injection to evaluate the clinical improvement of mouth opening. Methods. From February to May 2013 ten consecutive SSc patients were enrolled from the outpatient clinic of Plastic Surgery Department of Sapienza University of Rome. Patients were divided into two groups as follows: 5 patients were treated with fat transplantation and 5 patients received infiltration of ADSCs produced by cell factory of our institution. To value mouth opening, we use the Italian version of Mouth Handicap in Systemic Sclerosis Scale (IvMHISS). Mouth opening was assessed in centimetres (Maximal Mouth Opening, MMO). In order to evaluate compliance and physician and patient satisfaction, we employed a Questionnaire of Satisfaction and the Visual Analogic Scale (VAS) performed before starting study and 1 year after the last treatment. Results and Conclusion. We noticed that both procedures obtained significant results but neither one emerged as a first-choice technique. The present clinical experimentation should be regarded as a starting point for further experimental research and clinical trials.
EGR1 and the ERK‐ERF axis drive mammary cell migration in response to EGF (2011)

The signaling pathways that commit cells to migration are incompletely understood. We employed human mammary cells and two stimuli: epidermal growth factor (EGF), which induced cellular migration, and serum factors, which stimulated cell growth. In addition to strong activation of ERK by EGF, and AKT by serum, early transcription remarkably differed: while EGF induced early growth response-1 (EGR1), and this was required for migration, serum induced c-Fos and FosB to enhance proliferation. We demonstrate that induction of EGR1 involves ERK-mediated down-regulation of microRNA-191 and phosphorylation of the ETS2 repressor factor (ERF) repressor, which subsequently leaves the nucleus. Unexpectedly, knockdown of ERF inhibited migration, which implies migratory roles for exported ERF molecules. On the other hand, chromatin immunoprecipitation identified a subset of direct EGR1 targets, including EGR1 autostimulation and SERPINB2, whose transcription is essential for EGF-induced cell migration. In summary, EGR1 and the EGF-ERK-ERF axis emerge from our study as major drivers of growth factor-induced mammary cell migration.
Reconstruction does not reduce tibial translation in the cruciate-deficient knee (2001)

We have assessed the effectiveness of reconstruction of the anterior cruciate ligament (ACL) in reducing functional tibial translation (TT). The gait of 11 ACL-deficient patients was studied using Vicon equipment before and after surgery. Measurements of the angle between the patellar tendon and the long axis of the tibia were obtained in order to calculate TT in the sagittal plane relative to the uninjured limb during standing and walking. Before surgery, patients did not show abnormal TT on the injured side, but after surgery significant anterior TT was found in the operated limb for every parameter of gait. Abnormal anterior TT occurring during activity does not seem to be reduced by reconstruction; rather, it increases. It may be that the increased translation results from relaxation of excess contraction of the hamstring muscles, since compensatory muscle activity no longer is required in a reconstructed knee. The reduction of TT may not be an appropriate objective in surgery on the ACL.
Time: Temperature superposition principle: Application of WLF equation in polymer analysis and composites (2014)

Polymers are the most studied viscoelastic material. The shorter times (high frequencies) corresponding to lower temperatures and long times (low frequencies) to high temperatures. This represents the quantitatively applied time-temperature superposition (TTS). Use of the Williams- Landel-Ferry (WLF) equation and the time-temperature superposition principle enables prediction and modeling of the mechanical and rheological properties of polymeric systems outside the timescale of the experiment. Application and validity of the TTS principle and WLF equation in polymer blends, composites, biopolymers and polymer networks will be discussed in this review.
Supporting Effective Interaction with Tabletop Groupware (2006)

This workshop position paper describes our prior and ongoing research on horizontal computing systems, which is focused on understanding how interactive tables can effectively support co-located computer-supported collaborative work. We describe our recent contributions in the areas of multi-user coordination policies for interactive tables, using audio as a means of supplementing a tabletop display with private information, and exploring appropriate graphical layouts for horizontal interfaces. We also discuss our ongoing work in developing cooperative tabletop gestures and evaluating the potential of tabletop computing for educational activities.
Impedance characterization and modelling of an improved patch clamp device (2009)

The gold standard for studying the properties of ion channels is the patch clamp, a technique that measures pA currents passing through ion channels in an isolated patch of cell membrane. The authors sought to design an improved device for whole-cell patch clamp recordings using nanoscale pipettes which more readily form seals with the cell membrane and a movable metal electrode to decrease the access resistance, increase the signal bandwidth, and clear debris from the pipette tip. Electrical characterization of the instrument by impedance spectroscopy showed that advancing the metal electrode towards the pipette tip decreased the impedance distinctly in different frequency bands, the greatest decrease occurring between 1 and 100 kHz, and the smallest at 100 kHz. Finite element simulations of the electrode, incorporating the electrode/electrolyte interface, suggest that optimal signal transmission can be achieved with athick-walled pipette, nearly filled with alarge Ag/AgCl electrode, whose impedance can be reduced through surface modification.