gebhart/patrepeval huggingface dataset:
720 CUE-102 selectively activates and expands WT1-specific T cells for the treatment of patients with WT1+ malignancies (2021)

<h3>Background</h3> Wilms9 Tumor 1 (WT1) was ranked as the highest priority antigen for therapeutic targeting in an effort by the National Cancer Institute. Development of novel modalities targeting WT1 provide a significant opportunity to address high unmet medical need in WT1-positive malignancies, including AML, ovarian, endometrial, breast, lung, colorectal and pancreatic cancer. Leveraging the Immuno-STAT platform of targeted IL-2 therapies, and the ongoing development of CUE-101, CUE-102 is being developed as a novel therapeutic fusion protein to selectively activate tumor antigen-specific T cells to treat WT1-expressing cancers. CUE-102 consists of two human leukocyte antigen (HLA) molecules presenting a WT1 peptide, four affinity-attenuated human interleukin-2 (IL-2) molecules, and an effector attenuated human immunoglobulin G (IgG1) Fc domain. <h3>Methods</h3> Human PBMCs were tested to demonstrate cellular activity and specificity of CUE-102, while in vivo activity of CUE-102 was assessed in HLA-A2 transgenic mice. HLA-A2/WT1-specific TCRs were validated and expressed in primary human CD8 T cells. Tetramer staining and flow cytometry identified cell populations and activation markers. <h3>Results</h3> Multiple in vitro assessments demonstrate that CUE-102 selectively activates and expands WT1-specific CD8+ T cells from PBMC of healthy and cancer bearing donors. These CUE-102-expanded CD8+ T cells exhibit polyfunctional and cytotoxic responses upon challenge with WT1-presenting target cells. In addition, significant functional attenuation of the IL-2 components of CUE-102 was shown, similar to preclinical results obtained with CUE-101. In vivo studies in HLA-A2 transgenic mice confirm that CUE-102 elicits and expands polyfunctional WT1-specific CD8+ T cells from naïve and previously immunized mice without significantly altering the frequencies of other immune lineages. The WT1-specific CD8+ T cells expanded in vivo exhibit polyfunctionality in response to peptide-loaded target cells, and selectively kill WT1-presenting target cells in vivo. <h3>Conclusions</h3> CUE-102 elicits selective expansion of a WT1-specific population of cytotoxic CD8+ T cells both in vitro and in vivo. These results, together with its similarity to CUE-101, support its anticipated tolerability profile and potential for clinical efficacy in a Phase 1 trial planned to initiate in 2022. <h3>Ethics Approval</h3> All animal studies followed guidance from the SmartLabs Institutional Animal Care and Use Committee protocol MIL-100 and were performed in compliance with federal guidelines.
The global epidemiology of diabetes mellitus. (1983)

Systematic studies of diabetes prevalence and incidence are now indicating the extent and impact of the disease and its complications. A major handicap in establishing a true global picture has been the lack of uniformity in defining and classifying diabetes, and an additional limiting factor has been the grouping of different types of diabetes in published prevalence data. It appears the prevalence of insulin dependent (Type 1) and non-insulin dependent (Type 2) diabetes varies between and within ethnic groups, e.g. rural versus urban dwellers, thus making it difficult to compare data from different countries. However, this fact provides unique opportunities to study the relative importance of genetic and environmental factors in the aetiology of diabetes and its micro- and macrovascular complications. Probably the most urgent needs have been the standardization of classification and criteria, and of epidemiological methodology. This paper will cover the epidemiology of diabetes in terms of the new WHO classification: Insulin dependent diabetes mellitus = Type 1. Non-insulin dependent diabetes mellitus = Type 2. Other types, e.g. pancreatic or tropical malnutrition, endocrine, drug induced, etc. The main forms of diabetes seen in developed countries are Types 1 and 2. They appear to be two distinct clinical entities, but the concept of genetic-environmental interaction in their causation is probably equally applicable. In developing countries, Type 2 diabetes appears to be the most common form, but tropical malnutrition diabetes also occurs in many regions of the globe.
Investigation of the Impact of High Temperatures on the Switching Kinetics of Redox‐Based Resistive Switching Cells using a High‐Speed Nanoheater (2017)

Abstract Ionic transport greatly influences the switching kinetics of filamentary resistive switching memories and depends strongly on temperature and electric fields. To separate the impact of both parameters on the switching kinetics and to further deepen the understanding of the influence of local Joule heating, a nanometer‐sized heating structure is employed. It consists of a 100 nm wide Pt electrode which, due to Joule heating, serves as heating source upon an electrical stimulus. These self‐heating properties are underlined by a 3D finite elements simulation model, which confirms a temperature increase of almost 500 K. Experimental electrical pulse measurements indicate that for this temperature a steady state is achieved in less than 100 ns. By employing this heating structure, kinetic measurements of a Pt/Ta 2 O 5 /Ta cell are performed at different temperatures and reveal that significantly decreased SET times are obtained with increasing temperature. This effect is accompanied by an increasing slope of the current prior to the SET event. The experimental results are further confirmed by predictions of an analytical model based on ionic conduction.
Presence of cartilage‐derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitro (1998)

Objective To investigate the effects of the cartilage-derived morphogenetic proteins (CDMPs) in an in vitro cartilage explant model that mimics the chondrocytic response to matrix depletion, and to demonstrate their presence in articular cartilage. Methods Adult bovine articular cartilage and postmortem specimens from adult human donors with and without osteoarthritic (OA) lesions were stained by immunohistochemistry using polyclonal antibodies specific for CDMP-1 and CDMP-2. Extracts of bovine articular cartilage were analyzed by Western blotting for the presence of the CDMPs. Bovine articular cartilage explants were depleted of their matrix by trypsin digestion, followed by a 7-day culture period in a chemically defined serum-free basal medium (BM), with or without recombinant CDMPs 1 and 2. The metabolic activity of chondrocytes was measured by 35S-sulfate incorporation into macromolecules. Newly synthesized proteoglycans (PGs) were analyzed using Sephacryl S-500 HR gel chromatography. The expression levels of the messenger RNA (mRNA) for chondrogenic markers were investigated by Northern analysis. Results CDMP-1 and CDMP-2 were detected in both bovine and human healthy and OA articular cartilage. Treatment of matrix-depleted cartilage explants with CDMPs 1 and 2 increased equally the incorporation of 35S-sulfate into PGs compared with tissue maintained in BM. Gel chromatography analysis indicated that aggrecan was the predominant PG species. Northern blot analysis showed that the expression of link protein, type II collagen, and aggrecan mRNA transcripts was not modulated by CDMP treatment. Conclusion This study shows the presence of CDMP-1 and CDMP-2 in adult bovine and human articular cartilage. In addition, our in vitro data indicate that CDMPs 1 and 2 stimulate the metabolic activity of articular chondrocytes. Therefore, these signaling molecules may be contributing to the maintenance of the integrity of the joint surface.
Complex architectures through living polymerizations. The synthesis of "once-broken worms" and triblock copolymers using bimetallic initiators (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComplex architectures through living polymerizations. The synthesis of "once-broken worms" and triblock copolymers using bimetallic initiatorsSusanne M. Hoff and Bruce M. NovakCite this: Macromolecules 1993, 26, 15, 4067–4069Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/ma00067a056https://doi.org/10.1021/ma00067a056research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Staphylococcus aureus endocarditis: distinct mechanisms of bacterial adhesion to damaged and inflamed heart valves (2019)

Cardiac valve damage and inflammation predispose to S. aureus endocarditis via distinct mechanisms. These findings may have important implications for the development of new preventive strategies, as some interventions might be effective in one risk state, but not in the other.
Ultrafast Optical Demultiplexer Using a Spincoated Squarylium-Dye Film (2002)

We fabricated ultrafast nonlinear optical films of squarylium J-aggregates and studied their properties including the absorption spectrum, the refractive index, the third-order nonlinear optical coefficients, the extent of absorption saturation, and the recovery of absorption saturation. The transmittance of the film was increased by 30% due to absorption saturation at a pump energy of several hundreds fJ/μm2/pulse. The half decay time constant of absorption saturation was found to be approximately 100 fs for off-resonant excitation. Two-dimensional demultiplexing was demonstrated using the squarylium film as a switching material. From a train of 8 optical pulses with 100 fs duration and 1 ps interval corresponding to a bit rate of 1Tbps, 2× 4 spatially resolved spots were obained. key words: squarylium, J aggregates, optical switch, Tbps, fem-
Endothelial-Derived Extracellular Vesicles Induce Cerebrovascular Dysfunction in Inflammation (2021)

Blood-brain barrier (BBB) dysfunction is a key hallmark in the pathology of many neuroinflammatory disorders. Extracellular vesicles (EVs) are lipid membrane-enclosed carriers of molecular cargo that are involved in cell-to-cell communication. Circulating endothelial EVs are increased in the plasma of patients with neurological disorders, and immune cell-derived EVs are known to modulate cerebrovascular functions. However, little is known about whether brain endothelial cell (BEC)-derived EVs themselves contribute to BBB dysfunction. Human cerebral microvascular cells (hCMEC/D3) were treated with TNFα and IFNy, and the EVs were isolated and characterised. The effect of EVs on BBB transendothelial resistance (TEER) and leukocyte adhesion in hCMEC/D3 cells was measured by electric substrate cell-substrate impedance sensing and the flow-based T-cell adhesion assay. EV-induced molecular changes in recipient hCMEC/D3 cells were analysed by RT-qPCR and Western blotting. A stimulation of naïve hCMEC/D3 cells with small EVs (sEVs) reduced the TEER and increased the shear-resistant T-cell adhesion. The levels of <i>microRNA-155,</i> VCAM1 and ICAM1 were increased in sEV-treated hCMEC/D3 cells. Blocking the expression of VCAM1, but not of ICAM1, prevented sEV-mediated T-cell adhesion to brain endothelia. These results suggest that sEVs derived from inflamed BECs promote cerebrovascular dysfunction. These findings may provide new insights into the mechanisms involving neuroinflammatory disorders.
Rationalizing Acid Zeolite Performance on the Nanoscale by Correlative Fluorescence and Electron Microscopy (2017)

The performance of zeolites as solid acid catalysts is strongly influenced by the accessibility of active sites. However, synthetic zeolites typically grow as complex aggregates of small nanocrystallites rather than perfect single crystals. The structural complexity must therefore play a decisive role in zeolite catalyst applicability. Traditional tools for the characterization of heterogeneous catalysts are unable to directly relate nanometer-scale structural properties to the corresponding catalytic performance. In this work, an innovative correlative super-resolution fluorescence and scanning electron microscope is applied, and the appropriate analysis procedures are developed to investigate the effect of small-port H-mordenite (H-MOR) morphology on the catalytic performance, along with the effects of extensive acid leaching. These correlative measurements revealed catalytic activity at the interface between intergrown H-MOR crystallites that was assumed inaccessible, without compromising the shape selective properties. Furthermore, it was found that extensive acid leaching led to an etching of the originally accessible microporous structure, rather than the formation of an extended mesoporous structure. The associated transition of small-port to large-port H-MOR therefore did not render the full catalyst particle functional for catalysis. The applied characterization technique allows a straightforward investigation of the zeolite structure-activity relationship beyond the single-particle level. We conclude that such information will ultimately lead to an accurate understanding of the relationship between the bulk scale catalyst behavior and the nanoscale structural features, enabling a rationalization of catalyst design.
Coherent Beam Combining of Fiber Amplifiers via LOCSET (Postprint) (2012)

Abstract : Fiber laser systems with a broad range of industrial, medical, and military applications have evolved rapidly over the past decade. Generally, fiber lasers offer several advantages over conventional solid state and chemical lasers including: compactness, near diffraction limited beam quality, superior thermal-optical properties, and high optical to optical conversion efficiencies. Despite their advantages and brisk development, fiber lasers are still behind both chemical and bulk solid state lasers in terms of total output power. Currently, the intensity, and hence power available from single-mode optical fibers are limited by optical surface damage, thermal loads, and nonlinear optical effects.
Placement Strategies for Internet-Scale Data Stream Systems (2008)

Optimally assigning streaming tasks to network machines is a key factor that influences a large data-stream-processing system's performance. Although researchers have prototyped and investigated various algorithms for task placement in data stream management systems, taxonomies and surveys of such algorithms are currently unavailable. To tackle this knowledge gap, the authors identify a set of core placement design characteristics and use them to compare eight placement algorithms. They also present a heuristic decision tree that can help designers judge how suitable a given placement solution might be to specific problems.
Molecular Structural Design of Conjugated Microporous Poly(Benzooxadiazole) Networks for Enhanced Photocatalytic Activity with Visible Light (2015)

A simple structural design principle and band position alignment of conjugated microporous polymers for enhanced photocatalytic efficiency is presented. The valence and conduction band positions of the polymer networks can be fine-tuned by altering the substitution positions on the centered phenyl unit to match the required redox potential of the catalytic reactions under visible light.
Portable Symmetric Key Container (2008)

This document specifies a symmetric key format for transport and
provisioning of symmetric keys (for example One Time Password (OTP)
shared secrets or symmetric cryptographic keys) to different types of
crypto modules such as a strong authentication device. The standard
key transport format enables enterprises to deploy best-of-breed
solutions combining components from different vendors into the same
infrastructure. This work is based on earlier work by the members of
OATH (Initiative for Open AuTHentication) to specify a format that can
be freely distributed to the technical community. The authors believe
that a common and shared specification will facilitate adoption of
two- factor authentication on the Internet by enabling
interoperability between commercial and open-source implementations.
Optical Properties of Graphene Nanoribbons Encapsulated in Single-Walled Carbon Nanotubes (2013)

We report the photoluminescence (PL) from graphene nanoribbons (GNRs) encapsulated in single-walled carbon nanotubes (SWCNTs). New PL spectral features originating from GNRs have been detected in the visible spectral range. PL peaks from GNRs have resonant character, and their positions depend on the ribbon geometrical structure in accordance with the theoretical predictions. GNRs were synthesized using confined polymerization and fusion of coronene molecules. GNR@SWCNTs material demonstrates a bright photoluminescence both in infrared (IR) and visible regions. The photoluminescence excitation mapping in the near-IR spectral range has revealed the geometry-dependent shifts of the SWCNT peaks (up to 11 meV in excitation and emission) after the process of polymerization of coronene molecules inside the nanotubes. This behavior has been attributed to the strain of SWCNTs induced by insertion of the coronene molecules.
Strength and Latency of Mean Cerebral Blood Flow Velocity and Mean Arterial Pressure Coupling during Propofol General Anesthesia in Subjects Undergoing Coronary Artery Bypass Graft (2020)

Cerebral autoregulation (CA), namely the mechanism aiming at maintaining mean cerebral blood flow (MCBF) constant in spite of variations of mean arterial pressure (MAP), was investigated by means of cross-correlation function (CCF) between MCBF velocity (MCBFV) and MAP in subjects undergoing coronary artery bypass grafting before (PRE) and after (POST) the induction of propofol anesthesia. The null hypothesis of coupling was tested via a surrogate approach over the CCF minima and maxima detected at lags closest to 0. Both positive and negative lags were considered and monitored in correspondence of the considered CCF values. Results suggest that MCBFV and MAP were significantly associated during both PRE and POST but the maximal positive association was reduced in POST and occurred more likely at 0 lag during POST than PRE. Further studies are needed to understand whether the reduced MCBFV-MAP positive association and time shift implies the maintenance of a suitable CA level during propofol anesthesia.
Dynamics of Weed Populations—Roger Cousens and (A.) Martin Mortimer, 1995, Cambridge University Press, Cambridge, U.K., 332 pp. ISBN 0-521-49649-7 (hard cover) £50; ISBN 0-521-49969-0 (paperback) £15. (1996)

Dynamics of Weed Populations—Roger Cousens and (A.) Martin Mortimer, 1995, Cambridge University Press, Cambridge, U.K., 332 pp. ISBN 0-521-49649-7 (hard cover) £50; ISBN 0-521-49969-0 (paperback) £15. - Volume 10 Issue 1
Preparation of Pyroelectric Pb1-xLaxTi1-x/4O3 Thin Films from Ceramic Target by RF Magnetron Sputtering (1994)

Pyroelectric Pb 1- x La x Ti 1- x /4 O 3 thin films of high quality have been obtained reproducibly by rf magnetron sputtering using a ceramic target. The effects of sputtering parameters on film composition and structure have been studied and related to plasma emission spectroscopy. By controlling the relative intensities of Pb * (406 nm) and Ti * (396 nm) emissions of the plasma, the sputtering conditions were optimized to produce stoichiometric and highly c -axis-oriented filins. Under stabilized conditions, use of the ceramic target offered stability of the plasma and a high deposition rate of 2 Å/s. The PLT film exhibited good pyroelectric parameters with a dielectric constant of 290 and a pyroelectric coefficient of 4.2×10 -8 C/cm 2 · K.
HMGB1 Expression and Secretion Are Increased Via TWEAK–Fn14 Interaction in Atherosclerotic Plaques and Cultured Monocytes (2013)

Our results indicate that TWEAK can regulate expression and secretion of HMGB1 in monocytes/macrophages, participating in the inflammatory response associated with atherosclerotic plaque development.
N-Fluorobenzenesulfonimide (NFSI) analogs with deprotectable substituents: synthesis of β-fluoroamines via catalytic aminofluorination of styrenes (2023)

The palladium-catalyzed aminofluorination of styrenes using novel <i>N</i>-fluorobenzenesulfonimide (NFSI) derivatives with deprotectable substituents, and the selective deprotection and transformation of the resulting products into amines under mild reaction conditions are herein disclosed.
Democratic Representations (2014)

Minimization of the $\ell_{\infty}$ (or maximum) norm subject to a constraint that imposes consistency to an underdetermined system of linear equations finds use in a large number of practical applications, including vector quantization, approximate nearest neighbor search, peak-to-average power ratio (or "crest factor") reduction in communication systems, and peak force minimization in robotics and control. This paper analyzes the fundamental properties of signal representations obtained by solving such a convex optimization problem. We develop bounds on the maximum magnitude of such representations using the uncertainty principle (UP) introduced by Lyubarskii and Vershynin, and study the efficacy of $\ell_{\infty}$-norm-based dynamic range reduction. Our analysis shows that matrices satisfying the UP, such as randomly subsampled Fourier or i.i.d. Gaussian matrices, enable the computation of what we call democratic representations, whose entries all have small and similar magnitude, as well as low dynamic range. To compute democratic representations at low computational complexity, we present two new, efficient convex optimization algorithms. We finally demonstrate the efficacy of democratic representations for dynamic range reduction in a DVB-T2-based broadcast system.
Random Polyester Transesterification:  Prediction of Molecular Weight and MW Distribution (1998)

A statistical model has been developed for the prediction of molecular weight and molecular weight distribution in transesterification reactions of diols onto polyesters (ideally polycondensated with a polydispersity of 2). The model was checked out on a transesterification reaction of PEG or diethylene glycol on PLLA, which is a simple and noncatalytic route for obtaining blends of low-molecular-weight block copolymers PEG−PLLA and low-molecular-weight PLLA, which have biomedical interest. From this mathematical model, it is possible to predict the change in molecular weight and molecular weight distribution as a function of the different experimental variables. Reactions were characterized by 1H NMR and GPC.
Prevalence of severe growth hormone deficiency. (1977)

Four hundred and forty-nine short children, who were all over 2-5 standard deviations below the mean height for age, were identified by screening the heights of 48 221 6- to 9-year-old children in three Scottish cities. Most were screened for growth hormone deficiency (GHD). The prevalence of severe GHD in this sample may have been as high as 1 in 4018, much higher than reported. The findings suggest that present referral patterns may account for the delayed or missed diagnosis of the condition in girls or children with less severe short stature.