gebhart/patrepeval huggingface dataset:
Differentially uniform mappings for cryptography (1994)

This work is motivated by the observation that in DES-like ciphers it is possible to choose the round functions in such a way that every non-trivial one-round characteristic has small probability. This gives rise to the following definition. A mapping is called differentially uniform if for every non-zero input difference and any output difference the number of possible inputs has a uniform upper bound. The examples of differentially uniform mappings provided in this paper have also other desirable cryptographic properties: large distance from affine functions, high nonlinear order and efficient computability.
V-Man generation for 3-D real time animation (2003)

The V-Man project has developed an intuitive authoring and intelligent system to create, animate, control and interact in real-time with a new generation of 3D virtual characters: The V-Men. It combines several innovative algorithms coming from Virtual Reality, Physical Simulation, Computer Vision, Robotics and Artificial Intelligence. Given a high-level task like walk to that spot or get that object, a V-Man generates the complete animation required to accomplish the task. V-Men synthesise motion at runtime according to their environment, their task and their physical parameters, drawing upon its unique set of skills manufactured during the character creation. The key to the system is the automated creation of realistic V-Men, not requiring the expertise of an animator. It is based on real human data captured by 3D static and dynamic body scanners, which is then processed to generate firstly animatable body meshes, secondly 3D garments and finally skinned body meshes.
All-Optical Distributed MIMO for LiFi: Spatial Diversity Versus Spatial Multiplexing (2022)

LiFi or networked optical wireless communication is likely to play an important role in offloading mobile data traffic from radio into the optical spectrum. As the number of Internet of Things (IoT) devices is growing, the RF spectrum becomes a rare resource. Imaging IoT sensors like cameras, ultrasonic devices, and Lidars have real-time requirements, need a high-capacity uplink, and operate in environments that cause or are sensitive against electromagnetic interference. In this paper, for the first time, we present realtime communication over an all-optical fixed-wireless LiFi link based on the distributed multiple-input multiple-output concept. For distributing the wireless signals, plastic optical fibers are used as an analog front-haul. We study the operation of the distributed multiple-input multiple-output link in two modes, i.e., spatial diversity and spatial multiplexing. For the diversity mode, a new combiner is presented, which can support equal gain as well as selection combining. We demonstrate that selection combining is highly effective and enables a similar LiFi performance in up- and downlink, as it is desirable for industrial applications. For the spatial multiplexing mode, we observe that the channel rank and the achievable throughput depend strongly on the user location. As effective solutions, we study the benefits of angular diversity and multiple-input multiple-output mode switching together with multi-user multiplexing and conclude that a dynamic switching between spatial diversity and spatial multiplexing is a practical approach.
Conversion of biomass to sugars via ionic liquid hydrolysis: process synthesis and economic evaluation (2012)

Abstract Replacement of fossil fuels with new sustainable resources is becoming crucial due to depleting petroleum reserves, increasing global energy demand, and arising environmental concerns. Lignocellulosic biomass can be an alternative to fossil resources as a sustainable and environmentally friendly feedstock for producing chemicals and fuels. One of the major challenges of biomass‐based technologies is to extract sugars that are covalently trapped inside the lignocellulosic biomass efficiently. Recently, ionic liquids (ILs) have been recognized as promising solvents for mild and rapid hydrolysis of biomass feedstocks with higher sugar yields. In this study, we first develop and then evaluate an IL‐based biomass hydrolysis strategy for large‐scale production of fermentable sugars from corn stover. Toward this aim, we develop a process simulation model based on the experimental studies reported by Binder and Raines ( P Natl Acad Sci USA 107: 4516–4521(2010)) and a simulated‐moving‐bed (SMB) system. We identify that the major cost driver is the IL cost. Our analysis suggests that process alternatives with lower IL consumption and/or separation strategies that would allow higher recycle of ILs should be studied. © 2012 Society of Chemical Industry and John Wiley &amp; Sons, Ltd
The colour of glass (2015)

3D-printing, along with other additive manufacturing (AM) and rapid prototyping (RP) techniques, involves building up structures in a layer-by-layer fashion based upon a computer design file. Such techniques are well-suited to the production of one-off, complex structures that would often be difficult to produce using traditional manufacturing methods. There has been rapid growth and interest in this field during recent years, and a range of techniques are now available which make use of many common materials such as plastic, metal, wood and ceramic. However, relatively little has been done to develop AM using glass. Since glass was first made, thousands of years ago in Mesopotamia, it has been appreciated because of its vibrant colours. To allow a successful design and print of any glass object, these colours have to be captured and classified in such a way that they can be incorporated in the CAD design of the object and lead to the desired result in the print. The colours of architectural glass are often classified by RAL charts [1] or by BS4800:2100 colour codes [2]. Both colour classification systems have been developed for paints and coatings, but are a good first approximation. What they cannot capture is, for example, that some glasses display different colours in reflection and transmission and/or the colour change occurring in glass when it is reheated. In 3D printed glass, gas inclusions are another source of colour changes. Scattering at the air/glass interface leads to the addition of white to the underlying glass colour. Using CIE chromaticity coordinates [3], glass samples are characterized before and after processing. We used two different measurement methods to determine colour coordinates as a function of sample thickness and frit size, to check how robust the results were as a function of the measurement method.
ATR-FTIR for Determining Optimal Cooling Curves for Batch Crystallization of Succinic Acid (2002)

The temperature profile applied during batch cooling crystallization affects the supersaturation level, which in turn affects the crystal size distribution. It is possible, in principle, to calculate the optimal cooling profile; however, the nucleation and growth kinetics are rarely known to the degree of accuracy necessary for this calculation. The current study demonstrates an alternative approach to determination of the optimal cooling profile without any prior knowledge of kinetic data or subsequent modeling. An attenuated total reflectance−Fourier transform infrared (ATR-FTIR) spectrometer was used to monitor the supersaturation level during batch cooling crystallization. The ATR-FTIR was interfaced to a LABMAX automatic reactor system that was used in a feedback mode to control the cooling rate so that the supersaturation level remained close to the solubility throughout the cooling process. The resulting temperature profile corresponds to the optimal operating conditions for the maximum in the mean crystal size.
Arylmethylamino steroids as antiparasitic agents (2017)

In search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound 1o is fast acting and highly active against intraerythrocytic stages of chloroquine-sensitive and resistant Plasmodium falciparum parasites (IC<sub>50</sub> 1-5 nM) as well as against gametocytes. In P. berghei-infected mice, oral administration of 1o drastically reduces parasitaemia and cures the animals. Furthermore, 1o efficiently blocks parasite transmission from mice to mosquitoes. The steroid compounds show low cytotoxicity in mammalian cells and do not induce acute toxicity symptoms in mice. Moreover, 1o has a remarkable activity against the blood-feeding trematode parasite Schistosoma mansoni. The steroid and the hydroxyarylmethylamino moieties are essential for antimalarial activity supporting a chelate-based quinone methide mechanism involving metal or haem bioactivation. This study identifies chemical scaffolds that are rapidly internalized into blood-feeding parasites.
Using AAC Technology to Access the World (2012)

This paper describes the monumental shift in the nature of augmentative and alternative communication (AAC) access that has occurred over the past three decades. In its earliest days AAC technology was directed at enabling interpersonal face-to-face interactions mainly for persons with physical impairment. Contemporary AAC access attempts to mirror the access needs of a broader population. Accordingly AAC access to today's mainstream technologies expands the focus from interpersonal communication to access of information and services over the expanding World Wide Web. With this expanded view comes a new range of challenges and opportunities. At the same time AAC has expanded its reach to include more people with a wider range of complex communication needs.
Data from A Functional Screen Identifies miRs That Induce Radioresistance in Glioblastomas (2023)

&lt;div&gt;Abstract&lt;p&gt;The efficacy of radiotherapy in many tumor types is limited by normal tissue toxicity and by intrinsic or acquired radioresistance. Therefore, it is essential to understand the molecular network responsible for regulating radiosensitivity/resistance. Here, an unbiased functional screen identified four microRNAs (miR1, miR125a, miR150, and miR425) that induce radioresistance. Considering the clinical importance of radiotherapy for patients with glioblastoma, the impact of these miRNAs on glioblastoma radioresistance was investigated. Overexpression of miR1, miR125a, miR150, and/or miR425 in glioblastoma promotes radioresistance through upregulation of the cell-cycle checkpoint response. Conversely, antagonizing with antagomiRs sensitizes glioblastoma cells to irradiation, suggesting their potential as targets for inhibiting therapeutic resistance. Analysis of glioblastoma datasets from The Cancer Genome Atlas (TCGA) revealed that these miRNAs are expressed in glioblastoma patient specimens and correlate with TGFβ signaling. Finally, it is demonstrated that expression of miR1 and miR125a can be induced by TGFβ and antagonized by a TGFβ receptor inhibitor. Together, these results identify and characterize a new role for miR425, miR1, miR125, and miR150 in promoting radioresistance in glioblastomas and provide insight into the therapeutic application of TGFβ inhibitors in radiotherapy.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Implications:&lt;/b&gt; Systematic identification of miRs that cause radioresistance in gliomas is important for uncovering predictive markers for radiotherapy or targets for overcoming radioresistance. &lt;i&gt;Mol Cancer Res; 12(12); 1767–78. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Protein is linked to the 5' end of poliovirus RNA by a phosphodiester linkage to tyrosine (1978)

Purification and partial characterization of the poliovirus RNA-linked protein (VPg) are described. VPg has been freed from the RNA by ribonuclease digestion and phenol extraction. Gel filtration chromatography of VPg-pUp (labeled with 32P) in 0.5% sodium dodecyl sulfate or 6 M guanidine HCl indicates that it has a molecular weight of about 12,000. VPg is bound to the 5' end of poliovirion RNA by a phosphodiester bond between a tyrosine residue in the VPg molecule and the 5'-terminal uridine. After acid hydrolysis of [3H]tyrosine-labeled VPg-pU, free tyrosine can be released by venom phosphodiesterase. Acid hydrolysis of VPg-p labeled with either 32P or [3H] tyrosine yields tyrosine-phosphate. There appears to be only 1 tyrosine residue per VPg molecule.
Effects of e-beam curing on glass structureand mechanical properties of nanoporous organosilicate thin films (2010)

Abstract Structural characterization techniques, including solid-state nuclear magnetic resonance and Fourier transform infrared spectroscopies, were used in conjunction with mechanical testing to study the effects of thermally activated electron bombardment curing on organosilicate thin films. The electron beam process produced significant improvements in elastic modulus and fracture resistance while still preserving low dielectric constant. Detailed and quantitative analysis was used to elucidate fundamental curing effects on glass structure, including changes in film composition and local bond rearrangements. Enhancements in fracture properties with curing are shown to be due to increased network bond density resulting from changes in network connectivity coupled with moderate film densification.
Characterization of a glucansucrase fromLactobacillus reuteriE81 and production of malto-oligosaccharides (2019)

Glucansucrases, which can be produced by different Lactic Acid Bacteria (LAB), catalyze the synthesis of α-glucans with different structures and properties using sucrose as substrate. In this study, a novel glucansucrase (GTFA) from Lactobacillus reuteri E81 was identified and heterologously expressed. Alignments of GTFA with other glucansucrases revealed its novelty and a putative 3D model structure was obtained. The biochemical properties of the truncated enzyme without the N-terminal variable region, GTFA-ΔN, was characterized. The Km and Vmax were found to be 7.5 mM and 1.49 IU/mg, respectively, and it showed optimum activities at pH 7 and at 50 °C. The GTFA-ΔN produced in vitro an α-glucan with (α1 → 3) and (α1 → 6) glycosidic linkages using sucrose as the substrate. Importantly, GTFA-ΔN synthesized DP = 9 oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively, as detected by TLC, HPLC, LC-MS and NMR analysis.
Stiffness and Beyond (2018)

Brain magnetic resonance elastography (MRE) was developed on the basis of a desire to "palpate by imaging" and is becoming a powerful tool in the investigation of neurophysiological and neuropathological states. Measurements are acquired with a specialized MR phase-contrast pulse sequence that can detect tissue motion in response to an applied external or internal excitation. The tissue viscoelasticity is then reconstructed from the measured displacement. Quantitative characterization of brain viscoelastic behaviors provides us an insight into the brain structure and function by assessing the mechanical rigidity, viscosity, friction, and connectivity of brain tissues. Changes in these features are associated with inflammation, demyelination, and neurodegeneration that contribute to brain disease onset and progression. Here, we review the basic principles and limitations of brain MRE and summarize its current neuroanatomical studies and clinical applications to the most common neurosurgical and neurodegenerative disorders, including intracranial tumors, dementia, multiple sclerosis, amyotrophic lateral sclerosis, and traumatic brain injury. Going forward, further improvement in acquisition techniques, stable inverse reconstruction algorithms, and advanced numerical, physical, and preclinical validation models is needed to increase the utility of brain MRE in both research and clinical applications.
Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells (2014)

Prostaglandin E2 (PGE2) promotes Th17 expansion while otherwise inhibiting other CD4+ T cell subsets. Here, we identified a PGE2-dependent pathway that induces pathogenic Th17 cells in autoimmune disease and is regulated by the transcription factor RORC. Compared with other CD4+ cell types from healthy subjects, there is a surprising lack of the prostaglandin receptor EP2 on Th17 cells; therefore, we examined the hypothesis that RORγt, which is highly expressed in Th17 cells, mediates EP2 downregulation. Chromatin immunoprecipitation followed by DNA sequencing revealed that RORγt binds directly to Ptger2 (the gene encoding EP2 receptor) in Th17 cells isolated from WT mice. In Th17 cells isolated from humans, RORC repressed EP2 by directly silencing PTGER2 transcription, and knock down of RORC restored EP2 expression in Th17 cells. Compared with Th17 cells from healthy individuals, Th17 cells from patients with MS exhibited reduced RORC binding to the PTGER2 promoter region, resulting in higher EP2 levels and increased expression of IFN-γ and GM-CSF. Finally, overexpression of EP2 in Th17 cells from healthy individuals induced a specific program of inflammatory gene transcription that produced a pathogenic Th17 cell phenotype. These findings reveal that RORC directly regulates the effects of PGE2 on Th17 cells, and dysfunction of this pathway induces a pathogenic Th17 cell phenotype.
Bariatric surgery: an IDF statement for obese Type 2 diabetes (2011)

The International Diabetes Federation Taskforce on Epidemiology and Prevention of Diabetes convened a consensus working group of diabetologists, endocrinologists, surgeons and public health experts to review the appropriate role of surgery and other gastrointestinal interventions in the treatment and prevention of Type 2 diabetes. The specific goals were: to develop practical recommendations for clinicians on patient selection; to identify barriers to surgical access and suggest interventions for health policy changes that ensure equitable access to surgery when indicated; and to identify priorities for research. Bariatric surgery can significantly improve glycaemic control in severely obese patients with Type 2 diabetes. It is an effective, safe and cost-effective therapy for obese Type 2 diabetes. Surgery can be considered an appropriate treatment for people with Type 2 diabetes and obesity not achieving recommended treatment targets with medical therapies, especially in the presence of other major co-morbidities. The procedures must be performed within accepted guidelines and require appropriate multidisciplinary assessment for the procedure, comprehensive patient education and ongoing care, as well as safe and standardized surgical procedures. National guidelines for bariatric surgery need to be developed for people with Type 2 diabetes and a BMI of 35 kg/m(2) or more.
Chemical control of Vorticella bioactuator using microfluidics (2010)

In this report, we demonstrate a microfluidic platform to control the stalk contraction and extension of Vorticella convallaria by changing concentration of Ca2+ with pneumatically-actuated elastomeric microvalves. Habitation, extraction and control of V. convallaria were carried out in a PDMS-based microfluidic device. By treating the cells with the permeant saponin, external actuation of cell-anchoring stalk between an extended and contracted state was achieved by cyclic exposure of the cells to a Ca2+ buffer (10(-6) M) and a rinse buffer containing EGTA as a chelation agent. When solutions were switched, the stalk contracted and extended responding to the ambient Ca2+ concentration change. The length of the stalk changed between 20 and 60 microm, resulting in a working distance of about 40 microm.
CK2¿, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells (2014)

The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant in several types of cancer including mesothelioma. Protein kinase CK2 affects several cell signaling pathways through the mechanism of phosphorylation. Protein and mRNA levels of CK2α and Gli1 were tested by quantitative RT-PCR and immunohistochemistry staining in mesothelioma samples and cell lines. Down-regulated Gli1 expression and transcriptional activity were demonstrated by RT-PCR, Western blot and luciferase reporter assay. In this study, we show that CK2α is over-expressed and a positive regulator of Hegdehog/Gli1 signaling in human malignant pleural mesothelioma. First of all, we found that the mRNA levels of CK2α and Gli1 were broadly elevated and correlated (n=52, r=0.401, P < 0.05), compared with LP9 (a normal mesothelial cell line). We then investigated their expression at the protein level, and found that all the 7 mesothelioma cell lines tested showed positive staining in CK2α and Gli1 immunohistochemistry. Correlation analysis by Pearson test for CK2α and Gli1 expression in the 75 mesothelioma tumors and the 7 mesothelioma cell lines showed that the two protein expression was significantly correlated (n=82, r=0.554, P < 0.01). Furthermore, we demonstrated that Gli1 expression and transcriptional activity were down-regulated after CK2α was silenced in two mesothelioma cell lines (H28 and H2052). CK2α siRNA also down-regulated the expression of Hh target genes in these cell lines. Moreover, treatment with a small-molecule CK2α inhibitor CX-4945 led to dose-dependent inhibition of Gli1 expression and transcriptional activity. Conversely, forced over-expression of CK2α resulted in an increase in Gli1 transcriptional activity in H28 cells. Thus, we report for the first time that over-expressed CK2α positively regulate Hh/Gli1 signaling in human mesothelioma.
Melanocortin Receptors: Ligands and Proteochemometrics Modeling (2003)

The melanocortin receptors exist in five subtypes, MC(1-5)R. These receptors participate in important regulations of the immune system, central behavior, and endocrine and exocrine glands. Here we provide a short review on MCR subtype selective peptides and organic compounds with activity on the MCRs, developed in our laboratory. Also provided is an overview of our new proteochemometric modeling technology, which has been applied to model the interaction of MSH peptides with the MCRs.
Composition and Antimicrobial Activity of the Essential Oils of Five Taxa of Sideritis from Greece (2001)

The chemical compositions of the essential oils obtained from the aerial parts of five taxa of Sideritis were analyzed using various GC-MS techniques. A total of 99 different compounds was identified, and significant differences (qualitative and quantitative) were observed between the samples. The in vitro antimicrobial activity of the essential oils against six bacteria and three fungi is also reported.
Further Characterization of the [FeFe]‐Hydrogenase Maturase HydG (2011)

Abstract Recent work conducted in several laboratories has shown that the [FeFe]‐hydrogenase maturase HydG synthesizes both CO and CN – from tyrosine. We have very recently found that although CN – synthesis does not need the [4Fe‐4S] cluster found in the HydG C‐terminal domain, CO synthesis does require it. We have also proposed that the + H 2 N · –CH 2 –CO 2 – radical is a precursor for these two active site ligands. Here, we have extended our characterization of both the wild‐type enzyme and a ThiH‐like HydG truncated mutant, with small angle X‐ray scattering (SAXS) spectroscopy, homology modeling and functional studies.