gebhart/patrepeval huggingface dataset:
JetStream (2014)

The easily-accessible computation power offered by cloud infrastructures coupled with the revolution of Big Data are expanding the scale and speed at which data analysis is performed. In their quest for finding the Value in the 3 Vs of Big Data, applications process larger data sets, within and across clouds. Enabling fast data transfers across geographically distributed sites becomes particularly important for applications which manage continuous streams of events in real time. Scientific applications (e.g. the Ocean Observatory Initiative or the ATLAS experiment) as well as commercial ones (e.g. Microsoft's Bing and Office 365 large-scale services) operate on tens of data-centers around the globe and follow similar patterns: they aggregate monitoring data, assess the QoS or run global data mining queries based on inter site event stream processing. In this paper, we propose a set of strategies for efficient transfers of events between cloud data-centers and we introduce JetStream: a prototype implementing these strategies as a high performance batch-based streaming middleware. JetStream is able to self-adapt to the streaming conditions by modeling and monitoring a set of context parameters. It further aggregates the available bandwidth by enabling multi-route streaming across cloud sites. The prototype was validated on tens of nodes from US and Europe data-centers of the Windows Azure cloud using synthetic benchmarks and with application code from the context of the Alice experiment at CERN. The results show an increase in transfer rate of 250 times over individual event streaming. Besides, introducing an adaptive transfer strategy brings an additional 25% gain. Finally, the transfer rate can further be tripled thanks to the use of multi-route streaming.
Open subpectoral biceps tenodesis in patients over 65 does not result in an increased rate of complications (2017)

This study demonstrates that in patients over the age of 65, biceps tenodesis is a successful procedure when performed for biceps tendinopathy and concomitantly with other surgical procedures of the shoulder, and does not result in an increased rate of complications when compared to a group of patients under the age of 65.
Gap-state formation in two-dimensional ordered Bi layers on InAs(110) (1998)

The spectral density at the Fermi energy and the formation of adlayer-induced electronic states is studied by means of high energy resolution ultraviolet photoemission spectroscopy. A highly ordered (1\ifmmode\times\else\texttimes\fi{}1)-Bi monolayer deposited on InAs(110) induces a well-resolved, occupied electronic state in the InAs surface gap, attributed to p-like dangling bonds at the Bi atomic chains. Appropriate annealing of a Bi multilayer produces a (1\ifmmode\times\else\texttimes\fi{}2)-symmetry stable phase. Evolution of the spectral density close to the Fermi edge brings to light the metallicity of the (1\ifmmode\times\else\texttimes\fi{}2)-Bi layer induced by Bi---Bi bonding in the atomic chains.
Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold (2018)

The pharmacology of the M<sub>5</sub> muscarinic acetylcholine receptor (mAChR) is the least understood of the five mAChR subtypes due to a historic lack of selective small molecule tools. To address this shortcoming, we have continued the optimization effort around the prototypical M<sub>5</sub> positive allosteric modulator (PAM) ML380 and have discovered and optimized a new series of M<sub>5</sub> PAMs based on a chiral N-(indanyl)piperidine amide core with robust SAR, human and rat M<sub>5</sub> PAM EC<sub>50</sub> values <100 nM and rat brain/plasma K<sub>p</sub> values of ∼0.40. Interestingly, unlike M<sub>1</sub> and M<sub>4</sub> PAMs with unprecedented mAChR subtype selectivity, this series of M<sub>5</sub> PAMs displayed varying degrees of PAM activity at the other two natively G<sub>q</sub>-coupled mAChRs, M<sub>1</sub> and M<sub>3</sub>, yet were inactive at M<sub>2</sub> and M<sub>4</sub>.
Role of Molecular Architecture in Mechanical Failure of Glassy/Semicrystalline Block Copolymers:  CEC vs CECEC Lamellae (2003)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTADDITION / CORRECTIONThis article has been corrected. View the notice.Role of Molecular Architecture in Mechanical Failure of Glassy/Semicrystalline Block Copolymers: CEC vs CECEC LamellaeT. J. Hermel, S. F. Hahn, K. A. Chaffin, W. W. Gerberich, and F. S. BatesView Author Information Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455; Dow Chemical Company, Midland, Michigan 48674; and Medtronic Corp., Brooklyn Center, Minnesota 55430 Cite this: Macromolecules 2003, 36, 7, 2190–2193Publication Date (Web):March 11, 2003Publication History Received12 December 2002Revised8 February 2003Published online11 March 2003Published inissue 1 April 2003https://pubs.acs.org/doi/10.1021/ma021754whttps://doi.org/10.1021/ma021754wrapid-communicationACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views1083Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Copolymers,Deformation,Materials,Transmission electron microscopy,X-ray scattering Get e-Alerts
Analysis of the Interaction Among Power Converters Through Their Synchronization Mechanism (2019)

Recent studies have shown the importance of considering the synchronization mechanism of a grid-connected converter in its stability assessment. Moreover, it is often taken for granted that synchronization units of grid-connected converters operating nearby may interact with each other, but this topic has not yet been deeply investigated in the literature. In this paper, the interaction between synchronization units of grid-connected converters is investigated by means of impedance-based analysis. A multiple-inputs multiple-outputs analysis is required and a stability margin is introduced, based on the calculation of the norm of the equivalent grid impedance and equivalent output admittance of the converter. The sensitivity of the stability margin to parameter variations (e.g., grid impedance, bandwidth of the synchronization loop of each converter) is assessed by means of Monte Carlo simulations. Time-domain simulations as well as experimental results in a laboratory environment using a power hardware-in-the-loop test bench are performed so as to validate the presented frequency-domain analysis.
Heat‐Setting of Polyester Films (2023)

Heat-setting, or constrained high-temperature annealing, is an important step in the tenter-frame (tentering) process commonly used for making biaxially oriented polyester films, with potentially significant impact on dimensional stability, mechanical properties, and other important physical characteristics of the stretched film. Drawing mostly from the study of Greener et al., this chapter illustrates the effects of a controlled heat-setting treatment on the morphology and physical performance of poly(ethylene terephthalate) and poly(ethylene-2,6-naphthalene dicarboxylate) films and assess the similarity and differences between these materials stemming from their different molecular structures. It discusses the microstructural changes induced by heat-setting and the implications of these changes to some macroscopic properties of the stretched films. Finally, the chapter summarizes the results and discusses practical implications to the manufacture of polyester films.
Leakage radiation microscopy of surface plasmon coupled emission: investigation of gain‐assisted propagation in an integrated plasmonic waveguide (2010)

Using a single-mode dielectric-loaded surface plasmon polariton waveguide doped with quantum dots, we were able to slightly increase the propagation length of the mode by stimulated emission of plasmon. We analyse the amplification phenomenon in the visible range by combining leakage radiation microscopy and surface plasmon coupled emission techniques.
Deadline-aware wireless sensor network routing: The JLAT metric (2017)

Multiple routing metrics have been proposed for maximizing throughput or guaranteeing reliable delivery of the data. Some of the most common used metrics, neglect the bursty behavior of the channel. A new metric improve this by taking burstiness into account. This creates a burst estimation of all links and allocates the maximum number of required slots in worst-case. Even though this is a solution for the worst-case scenario, this pessimistic approach cannot achieve the performance for applications with low deadline applications. In order to close the gap between these two metrics we propose a new routing metric called Joint LATency (JLAT). We use a better understanding of the bursts with respect to specific application deadlines via joint probability distributions of the link latencies. We show that the proposed metric achieves the expected trade-off for maximal throughput and burst consideration in order to deliver a routing decision depending on the application deadline requirement. We support this claim via simulations in an exemplary scenario.
Deletion of the Chemokine Receptor CCR1 Prolongs Corneal Allograft Survival (2007)

These studies provide, for the first time, evidence that targeting of specific chemokine pathways can significantly promote survival of corneal transplants, and suggest that select deletion or suppression of CCR1 can be a useful therapeutic target in corneal transplant immunity.
Photolithography of Bragg gratings in sol-gel-derived fibers (1994)

We report a novel photolithographic technique that facilitates the photogeneration of refractive index gratings in sol-gel derived silica fibers, based on the ability to produce changes in the index of refraction of a silica glass of the order of 0.1 to 0.001. A porous sol-gel fiber impregnated with a photosensitive organometallic compound exhibits optical changes when exposed to light. Changes in transmission and refractive index can be induced and are permanent after consolidation of the porous glass matrix. Gratings have been produced in doped sol-gel fibers by exposing the fiber to UV light through a contact mask. The photoinduced grating is permanent after heat treatment of the fiber to 1200 degree(s)C. The uncomplicated nature of this process makes this a very promising approach for the fabrication of commercial fiber optic refractive index gratings for fiber lasers, fiber optic sensors, filters, and multiplexing schemes.
SUPRASPINAL AND SPINAL EFFECTS OF L-TRANS- PYRROLIDINE-2,4-DICARBOXYLIC ACID, AN INHIBITOR OF GLUTAMATE TRANSPORTERS, ON THE MICTURITION REFLEX IN URETHANE-ANESTHETIZED RATS (2008)

You have accessJournal of Urology1 Apr 2008SUPRASPINAL AND SPINAL EFFECTS OF L-TRANS- PYRROLIDINE-2,4-DICARBOXYLIC ACID, AN INHIBITOR OF GLUTAMATE TRANSPORTERS, ON THE MICTURITION REFLEX IN URETHANE-ANESTHETIZED RATS Masashi Honda, Ikuo Miyagawa, Michael B Chancellor, and Naoki Yoshimura Masashi HondaMasashi Honda More articles by this author , Ikuo MiyagawaIkuo Miyagawa More articles by this author , Michael B ChancellorMichael B Chancellor More articles by this author , and Naoki YoshimuraNaoki Yoshimura More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)61025-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "SUPRASPINAL AND SPINAL EFFECTS OF L-TRANS- PYRROLIDINE-2,4-DICARBOXYLIC ACID, AN INHIBITOR OF GLUTAMATE TRANSPORTERS, ON THE MICTURITION REFLEX IN URETHANE-ANESTHETIZED RATS." The Journal of Urology, 179(4S), p. 350 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 350 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Masashi Honda More articles by this author Ikuo Miyagawa More articles by this author Michael B Chancellor More articles by this author Naoki Yoshimura More articles by this author Expand All Advertisement PDF downloadLoading ...
High temperature compatible aluminum nitride resonating strain sensor (2011)

Aluminum nitride (AlN) is a promising material for harsh environment sensing applications due to its piezoelectric effect and mechanical stability at high temperatures. In this work, AlN double-ended tuning forks (DETF) are presented as a transduction element to measure mechanical loads by observing the resonance frequency shift. The fabrication process of the MEMS devices including the bonding step to a steel parallel is described. Device operation is demonstrated for strain sensing up to 91 °C and operation of the transducer without applied strain is demonstrated up to 570 °C.
CD28-independent induction of experimental autoimmune encephalomyelitis (2001)

Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated disease initiated by antigen-specific CD4(+) T cells. Signaling through CD28 is a critical second signal for activation of T cells, and CD28 knockout (CD28KO) mice have been reported to be resistant to induction of EAE. We now report that CD28KO mice have no intrinsic defect in mediating disease, because they developed EAE after passive transfer of primed T cells. After immunization, peripheral T cells from CD28KO mice were primed and developed memory phenotype, but had decreased antigen-specific IFN-gamma production as compared with cells from wild-type (WT) animals. Reimmunization of CD28KO mice brought out clinical disease and increased IFN-gamma production in vitro. Pathologically, there were cellular infiltrates in the central nervous system, in contrast to single-immunized mice. We show furthermore that blocking B7-1 or CTLA4, but not B7-2, in CD28KO mice induces disease after a single immunization. Thus, EAE can be induced in animals lacking CD28-dependent costimulation, suggesting that alternative costimulatory pathways were used. Blocking the OX40-OX40L costimulatory pathway differentially affected disease induction in CD28KO mice as compared with WT controls. Our data show that EAE may develop in the absence of CD28 T-cell costimulation. These findings have implications for therapies aimed at blocking costimulatory signals in autoimmune diseases.
The Survival Function of the Bcr-Abl Oncogene Is Mediated by Bad-Dependent and -Independent Pathways: Roles for Phosphatidylinositol 3-Kinase and Raf (2000)

The Bcr-Abl tyrosine kinase constitutively activates cytokine signal transduction pathways that stimulate growth and prevent apoptosis in hematopoietic cells. The antiapoptotic action of interleukin-3 (IL-3) has been linked to a signaling pathway which inactivates the proapoptotic protein Bad by phosphorylation through kinases such as Akt and Raf. Here we report also that expression of Bcr-Abl leads to phosphorylation of Bad in hematopoietic cells. Bad phosphorylation induced by Bcr-Abl is kinase dependent, requires phosphatidylinositol 3-kinase (PI3-kinase), and mitochondrial targeting of Raf, and occurs independently of Erk. The ability of Bcr-Abl to confer cytokine-independent survival to hematopoietic cells was compromised by inhibitors of PI3-kinase, as well as by a dominant negative form of Raf targeted to the mitochondria. Furthermore, when the capacity of Bcr-Abl to phosphorylate Bad was completely blocked by dominant negative Raf, a subpopulation of cells remained viable, providing evidence for Bad-independent survival pathways. This alternative survival pathway remained PI3-kinase dependent. Finally, Bcr-Abl, but not IL-3, inhibited the proapoptotic activity of overexpressed Bad. We conclude that the antiapoptotic function of Bcr-Abl is mediated through pathways involving PI3-kinase and Raf and that survival can occur in the absence of Bad phosphorylation.
Implementation of the Neural Engineering Framework on the TrueNorth Neurosynaptic System (2018)

The Neural Engineering Framework (NEF) provides a methodology for implementing algorithms and models using spiking neurons. Although it is possible to run simulations based on the NEF on Von Neumann hardware, neuromorphic hardware holds the promise of increased computational efficiency and lower power implementation. This work describes an implementation of the NEF on IBM's TrueNorth Neurosynaptic system. Using one TrueNorth chip, a NEF neural population of 629 neurons representing five dimensions is demonstrated on hardware. However, the crossbar array architecture itself, utilized in the TrueNorth hardware, can be used to compute the basic NEF calculations for any sized neural population, representing any dimensionality. The computation time is a function of the maximum values used in the computations.
Evaluation of vitamin E-diffused highly crosslinked polyethylene wear and porous titanium-coated shell stability: a seven-year randomized control trial using radiostereometric analysis (2019)

This is the first randomized controlled trial to report seven-year RSA results for VEPE. All wear rates were below the previously reported osteolysis threshold (0.1 mm per year). PTC shells demonstrated acceptable primary stability through seven years, as indicated by low migration and lack of aseptic loosening. However, patients with acetabular radiolucency were associated with higher shell migration and lower PROM scores. Cite this article: <i>Bone Joint J</i> 2019;101-B:760-767.
Scalability aspects of centralized control of MPLS access/aggregation network (2012)

We apply the concept of centralized control to the MPLS access/aggregation network segment of service provider networks. We describe a numerical model to capture the scale and scope of the access/aggregation network and explain the corresponding scalability issues. We compare this numerical model to the experimental results obtained on a test-bed with OpenFlow 1.1 compatible central controller and forwarding elements. We show that the central controller implementation we have mostly matches the performance requirements of the access/aggregation networks for different scenarios.
Development of 3% Chromium Linepipe Steel (2003)

Abstract We investigated several steels containing up to 5% chromium (Cr) with respect to their carbon dioxide (CO2) corrosion resistance in oil and gas environments. Steels containing 3% or more Cr showed improved corrosion performance compared to Cr free steels in a wet CO2 environment. This phenomenon was made clear by immersion tests, field tests and loop tests. Furthermore, we have developed a 3% Cr Electric Resistance Weld (ERW) linepipe steel with good Heat Affected Zone (HAZ) toughness in a simulated field weld using laboratory methods.
Clinical DNA Sequencer for Ultra-Low Cost Testing (2012)

We present a new sequencing instrument, the MINI, for sequencing DNA in the clinic or core research laboratory. Unlike all other DNA sequencing systems, which run only one or two samples at a time, the MINI can simultaneously run any number of flow cells between one and twenty. Each flow cell is designed to be disposable, low-cost and use very little reagent; thus, DNA from a single patient or specimen may be cost effectively sequenced without the need for indexing multiple samples in a single flow cell. This is an important feature for the clinic, as in addition to simplifying the sample preparation process, different sample may be kept physically separate (meters) from one another, thereby significantly reducing the chance of contamination or false diagnosis. Low cost (about $100 per sequencing test) is achieved through a unique sequencing by synthesis chemistry and low reagent consumption. Parallel flow cell processing and fluidics design results in high throughput (tens of tests per day). In addition to sequence-based clinical testing, the system supports targeted resequencing up to an exome per flow cell. Read lengths are driven by application requirements and are between 35-100 bp.
Model for bulk effects on Si interstitial diffusivity in silicon (1987)

Literature values for the diffusivity of the silicon interstitial or interstitialcy, I, range over several orders of magnitude and have activation energies between 1 and 4 eV. We propose a model for bulk trapping effects on the I diffusivity which provides a consistent explanation for the observed discrepancies. It reconciles the effects of different materials (float-zone, Czochralski, and epitaxial silicon) and processes (diffusion and gettering) on the apparent value of the I diffusivity. New experimental results which directly indicate substantial bulk effects in different types of silicon support the validity of the model.
Superchannel multiplexing using programmable multicast beamsteering in LCoS WSS (2017)

A method is presented for Nyquist superchannel combination within a WSS that avoids crosstalk, noise and loss issues of passive combiners.
On robustness against burst unsynchronized co-channel interference in semi-blind detection (2002)

Interference from other users and interference due to multipath propagation limit the capacity of wireless communication networks. As the number of users and the demand for new services in the networks increases, co-channel interference will be a limiting factor. This paper investigates the effects of burst unsynchronized co-channel interference on the performance of a joint channel estimation and detection algorithm. Further, the paper tries to give some insight in how to add training redundancy to a data frame in order to provide robustness against unsynchronized co-channel interference. From simulations and Cramer-Rao bound calculation we find that by using distributed training information elaborately it is possible to increase the robustness against unsynchronized co-channel interferers.
Hierarchical Object Parsing from Structured Noisy Point Clouds (2012)

Object parsing and segmentation from point clouds are challenging tasks because the relevant data is available only as thin structures along object boundaries or other features, and is corrupted by large amounts of noise. To handle this kind of data, flexible shape models are desired that can accurately follow the object boundaries. Popular models such as active shape and active appearance models (AAMs) lack the necessary flexibility for this task, while recent approaches such as the recursive compositional models make model simplifications to obtain computational guarantees. This paper investigates a hierarchical Bayesian model of shape and appearance in a generative setting. The input data is explained by an object parsing layer which is a deformation of a hidden principal component analysis (PCA) shape model with Gaussian prior. The paper also introduces a novel efficient inference algorithm that uses informed data-driven proposals to initialize local searches for the hidden variables. Applied to the problem of object parsing from structured point clouds such as edge detection images, the proposed approach obtains state-of-the-art parsing errors on two standard datasets without using any intensity information.