gebhart/patrepeval huggingface dataset:
Parameters Development for Optimum Deposition Rate in Laser DMD of Stainless Steel EN X3CrNiMo13-4 (2021)

Abstract Laser Direct Metal Deposition (DMD) has been developed as a manufacturing process to deposit coatings on existing materials and proves advantageous in Additive Manufacturing (AM) of complex and precise components. However, it is necessary to carefully determine the proper process parameter combinations to make this method economically viable for industries. The intent of this study is to address enhancement in productivity of laser DMD of stainless steel EN X3CrNiMo13-4. Accordingly, the effects of the main laser process parameters of laser power P , scan speed v , powder flow rate $$\dot{\mathrm{m}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mover> <mml:mi>m</mml:mi> <mml:mo>˙</mml:mo> </mml:mover> </mml:math> , and spot diameter s on track geometries and build-up rate are discussed. The regression analysis is conducted to derive correlations between the combined set of main parameters and deposition rate. The results show a good linear regression correlation of R 2 &gt;0.9 for the geometrical characteristic of aspect ratio, dilution, and deposition rate. The constructed processing map, using linear regression equations, presents proper process parameters selection in connection with deposition rate, aspect ratio, and dilution rate.
Nucleotide sequence of the 5S RNA gene and flanking regions interspersed with histone genes in Artemia (1987)

Journal Article Nucleotide sequence of the 5S RNA gene and flanking regions interspersed with histone genes in Artemia Get access Joseph C. Bagshaw, Joseph C. Bagshaw Department of Biology and Biotechnology, Worcester Polytechnic InstituteWorcester, MA 01609, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Henry B. Skinner, Henry B. Skinner Department of Biology and Biotechnology, Worcester Polytechnic InstituteWorcester, MA 01609, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Timothy C. Burn, Timothy C. Burn Department of Biology and Biotechnology, Worcester Polytechnic InstituteWorcester, MA 01609, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Brian A. Perry Brian A. Perry Department of Biology and Biotechnology, Worcester Polytechnic InstituteWorcester, MA 01609, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 15, Issue 8, 24 April 1987, Page 3628, https://doi.org/10.1093/nar/15.8.3628 Published: 24 April 1987 Article history Received: 10 March 1987 Published: 24 April 1987
Secret Communication over Broadcast Erasure Channels with State-feedback (2014)

We consider a 1-to-$K$ communication scenario, where a source transmits private messages to $K$ receivers through a broadcast erasure channel, and the receivers feed back strictly causally and publicly their channel states after each transmission. We explore the achievable rate region when we require that the message to each receiver remains secret - in the information theoretical sense - from all the other receivers. We characterize the capacity of secure communication in all the cases where the capacity of the 1-to-$K$ communication scenario without the requirement of security is known. As a special case, we characterize the secret-message capacity of a single receiver point-to-point erasure channel with public state-feedback in the presence of a passive eavesdropper. We find that in all cases where we have an exact characterization, we can achieve the capacity by using linear complexity two-phase schemes: in the first phase we create appropriate secret keys, and in the second phase we use them to encrypt each message. We find that the amount of key we need is smaller than the size of the message, and equal to the amount of encrypted message the potential eavesdroppers jointly collect. Moreover, we prove that a dishonest receiver that provides deceptive feedback cannot diminish the rate experienced by the honest receivers. We also develop a converse proof which reflects the two-phase structure of our achievability scheme. As a side result, our technique leads to a new outer bound proof for the non-secure communication problem.
Multi-Ink Color-Separation Algorithm Improving Image Quality (2008)

Current color-printing technologies often use more than the minimum three or four inks: cyan, magenta, yellow, and black (CMYK). When the number of inks exceeds three, there is the usual color-management one-to-many mapping problem. Additional constraints have to be applied to achieve greater determinacy. For CMYK ink sets, the black ink is constrained. When additional chromatic inks are added, traditional methods subdivide either colorimetric or colorant space to achieve a one-to-one mapping. However, these traditional methods cannot take advantage of all the ink combinations available for improving image quality. Alternatively, additional constraints can be defined as perceptual metrics such as color constancy, graininess, color gamut, and color look-up table smoothness. A novel color separation algorithm was developed in order to optimize color look-up tables for improved image quality. This algorithm was tested with a six-pigmented ink (CMYKGO), ink jet proofing printer. Various four and a six-ink look-up tables were created based on different metrics. The perceptual performances of these look-up tables in color reproduction accuracy, color inconstancy, graininess and gamut volume were evaluated. The results show that the additional inks not only extend color gamut but also provided the potential to improve print quality.
Reduction of friction by recombinant human proteoglycan 4 in IL‐1α stimulated bovine cartilage explants (2016)

A boundary lubricant attaches and protects sliding bearing surfaces by preventing interlocking asperity-asperity contact. Proteoglycan-4 (PRG4) is a boundary lubricant found in the synovial fluid that provides chondroprotection to articular surfaces. Inflammation of the diarthrodial joint modulates local PRG4 concentration. Thus, we measured the effects of inflammation, with Interleukin-1α (IL-1α) incubation, upon boundary lubrication and PRG4 expression in bovine cartilage explants. We further aimed to determine whether the addition of exogenous human recombinant PRG4 (rhPRG4) could mitigate the effects of inflammation on boundary lubrication and PRG4 expression in vitro. Cartilage explants, following a 7 day incubation with IL-1α, were tested in a disc-on-disc configuration using either rhPRG4 or saline (PBS control) as a lubricant. Following mechanical testing, explants were studied immunohistochemically or underwent RNA extraction for real-time polymerase chain reaction (RT-PCR). We found that static coefficient of friction (COF) significantly decreased to 0.14 ± 0.065 from 0.21 ± 0.059 (p = 0.014) in IL-1α stimulated explants lubricated with rhPRG4, as compared to PBS. PRG4 expression was significantly up regulated from 30.8 ± 19 copies in control explants lubricated with PBS to 3330 ± 1760 copies in control explants lubricated with rhPRG4 (p < 0.001). Explants stimulated with IL-1α displayed no increase in PRG4 expression upon lubrication with rhPRG4, but with PBS as the lubricant, IL-1α stimulation significantly increased PRG4 expression compared to the control condition from 30.8 ± 19 copies to 401 ± 340 copies (p = 0.015). Overall, these data suggest that exogenous rhPRG4 may provide a therapeutic option for reducing friction in transient inflammatory conditions and increasing PRG4 expression. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:580-589, 2017.
Luminal and basal subtyping of metastatic castration-resistant prostate cancer (mCRPC) and its clinical implications. (2018)

197 Background: The PAM50 gene expression classifier (PAM50) identifies luminal and basal subtypes and predicts response to androgen deprivation therapy in localized prostate cancer. The clinical utility of using PAM50 to molecularly subtype mCRPC was evaluated. Methods: PAM50 was applied to RNA expression data from 86 metastatic tumor biopsies from the SU2C-AACR-PCF West Coast Prostate Cancer Dream Team (WCDT; NCT02432001). Overall survival (OS) differences between luminal A (LuA), luminal B (LuB), or basal patients (pts) were determined using Kaplan-Meier analyses. PAM50 was also applied to 15,136 prospectively collected radical prostatectomy (RP) samples from the Decipher GRiD database (NCT02609269). Drug response signatures (DRS) for 89 drugs were derived using publicly available data from the NCI60 cell line panel, and applied to gene expression data from the RP samples to predict patient-specific drug sensitivities. Differences in DRS as a function of PAM50 subtype were assessed using the Pearson’s chi-squared test. Results: The application of PAM50 to mCRPC transcriptional data segregated pts into LuA, LuB, and basal populations (43%, 14%, and 43%, respectively). The median OS for LuA, LuB, and basal pts was 20.6 months, 9.5 months, and 10.4 months, respectively (p=0.04), which was consistent with localized prostate cancer where LuB pts have the worst prognosis. DRS analyses revealed statistically significant differences in drug sensitivities, with LuA and LuB pts predicted to be markedly more sensitive to docetaxel than basal pts (p&lt;0.00001), and basal pts predicted to be markedly more sensitive to platinums and etoposide than LuA and LuB pts (p&lt;0.00001). Conclusions: PAM50 subtyping is prognostic in mCRPC, with LuA pts demonstrating the longest OS. Luminal and basal subtypes have distinct in silico drug response profiles that may be associated with response to mCRPC therapies. Prospective testing of DRS as a biomarker to guide treatment in mCRPC is warranted. Clinical trial information: NCT02432001, NCT02609269.
Supplementary Table 1 from Selective Targeting of Interferon γ to Stromal Fibroblasts and Pericytes as a Novel Therapeutic Approach to Inhibit Angiogenesis and Tumor Growth (2023)

&lt;p&gt;PDF file, 61K, Blood parameters of B16 tumor-bearing mice.&lt;/p&gt;
Blockade of hypoxia-reoxygenation-mediated collagen type I expression and MMP activity by overexpression of TGF-β1delivered by AAV in mouse cardiomyocytes (2007)

Transforming growth factor (TGF)-beta(1) is one of the most pleiotropic and multifunctional peptides known. While the cardioprotective effect of TGF-beta(1) during ischemia is well known, the specific role of TGF-beta(1) in altering the cardiac remodeling process remains unclear. This study was designed to examine the regulation of hypoxia-reoxygenation-mediated collagen type I expression and activity of matrix metalloproteinases (MMPs) by overexpression of TGF-beta(1) in cultured HL-1 mouse cardiomyocytes. TGF-beta(1) was overexpressed in cardiomyocytes by transfection with adeno-associated virus (AAV)/TGF-beta(1)(Latent) or with AAV/TGF-beta(1)(ACT) (active TGF-beta(1)). Twenty-four hours of hypoxia followed by 3 h of reoxygenation (H-R) markedly enhanced (pro)collagen type I expression and activity of MMPs concomitant with an increase in reactive oxygen species (ROS) release and LOX-1 expression. Overexpression of TGF-beta(1) reduced these alterations induced by H-R. TGF-beta(1) overexpression also blocked H-R-mediated p38 and p44/42 MAPK activation. Transfection with AAV/TGF-beta(1)(ACT) was superior to that with AAV/TGF-beta(1)(Latent). These data for the first time demonstrate that H-R induces signals for cardiac remodeling in cardiomyocytes and TGF-beta(1) can modulate, possibly via antioxidant mechanism, these signals. These findings contribute to further understanding of the role of TGF-beta(1) in the cardiac remodeling process.
Generalized Commitment Alignment (2015)

The interoperability of interacting components means that their expectations of each other remain in agreement. A commitment captures what one agent (its creditor) may expect from another agent (its debtor). Chopra and Singh (CS however, such states may never obtain in enactments of real systems.Our approach retains and enhances CS (2) prove that it coincides with alignment; and (3) provide the computations by which a system of agents provably progresses toward alignment assuming eventual delivery of messages.
Topological interface states in multiscale spoof-insulator-spoof waveguides (2016)

The spoof-insulator-spoof (SIS) structure can serve as a waveguide for spoof surface plasmon polaritons (spoof SPPs). If a periodic geometry modulation in the wavelength scale is introduced to the SIS waveguide, this multiscale SIS (MSIS) waveguide possesses band gaps for spoof SPPs analogous to the band gaps in a photonic crystal. Inspired by the topological interface states found in photonic crystals, we construct an interface by connecting two MSIS waveguides with different topological properties (inverted Zak phases of bulk bands). The topological interface states in the MSIS waveguides are observed experimentally. The measured decay lengths of the interface states agree excellently with the numerical results. These localized interface states may find potential applications in miniaturized microwave devices.
Gastrostomy tube dependence and patient‐reported quality of life outcomes based on type of treatment for human papillomavirus‐associated oropharyngeal cancer: Systematic review and meta‐analysis (2021)

We examined the impact of treatment modality on gastrostomy tube dependence and patient-reported outcomes in human papillomavirus-associated oropharyngeal cancer (HPV-OPSCC). We performed systematic review and meta-analysis of functional outcomes 1-3 years after treatment. Twenty-three studies were included, reporting on 3127 patients treated for HPV-OPSCC. Gastrostomy tube dependence failed to show statistically significant difference between surgery with adjuvant therapy and chemoradiotherapy with cisplatin at 12 months (8.3% [95% CI: 3.1-15.9] vs. 4.2% [1.1-9.2], p = 0.37) and 24-36 months (10.5% [95% CI: 3.2-21.5] vs. 3.3% [2.0-4.9], p = 0.06). Surgery with adjuvant therapy was associated with worse University of Washington Quality of Life (UW-QOL) Swallowing (84 [95% CI: 80-88] vs. 89 [87-90], p = 0.03) and UW-QOL Overall scores (76 [95% CI: 72-80] vs. 84 [81-86], p = 0.001) compared to chemoradiotherapy with cisplatin at 12 months. Surgery with adjuvant therapy was associated with worse performance on certain measures of patient-reported swallow and overall function compared to chemoradiotherapy with cisplatin. Further randomized controlled trials are needed to directly compare functional outcomes after treatment for HPV-OPSCC.
A model of ultrasonic reflection matrix for multiple scattering evaluation (2020)

International audience
The Role of Bovine Intraepithelial Leukocyte-Mediated Cytotoxicity in Enteric Antiviral Defense (1992)

The defense of a mucosal surface against viral infection is dependent in part on the leukocyte population resident at that site. In this study, leukocytes from the bovine intestinal epithelium were isolated and assessed for their ability to inhibit in vitro replication of an enteric pathogen, bovine coronavirus (BCV). As well, the intraepithelial leukocytes (IEL) were tested for their ability to mediate different types of cytotoxicity. The IEL were able to inhibit virus replication, and this activity was markedly enhanced by interleukin-2 and tumor necrosis factor. This combination of cytokines has similar effects on IEL-mediated cytotoxicity, which implicated cytotoxicity as a mechanism by which viral replication was limited. The IEL demonstrated enhanced cytotoxic function when compared with lymphocytes isolated from other sites in the gut-associated or systemic immune system. The IEL mediated higher levels of IL-2-activated, antibody-dependent, and lectin-dependent cytotoxicity than did lymphocytes from mesenteric lymph nodes, Peyer's patches, or the spleen. This function may be a reflection of the type of cell recruited to the epithelium, as indicated by the increased prevalence of T cells, and particularly CD8+ cells in the IEL population. Cytokine activation and the presence of a recognition signal, such as antibody, resulted in a synergistic increase in the level of IEL-mediated cytotoxicity. This type of interaction could serve to enhance the efficiency of IEL cytotoxic cells in vivo. Thus IEL-mediated cytotoxicity has the potential to serve as a mechanism of defense to enteric viral infection.
Craniovertebral junction fixation with transarticular screws: biomechanical analysis of a novel technique (2003)

Biomechanically, Oc-C1 transarticular screws performed well enough to be considered as an alternative for Oc-C1 fixation, especially when instability at C1-2 is minimal. Techniques for augmenting these screws posteriorly by using a wired bone graft buttress, as is currently undertaken with C1-2 transarticular screws, may be needed for optimal performance.
Microbial enhanced oil recovery research. [Peptides] (1992)

The surface active lipopeptide produced by Bacillus licheniformis JF-2 was isolated to near apparent homogeneity. NMR experiments revealed that this compound consists of a heptapeptide with an amino acid sequence similar to surfactin and a heterogeneous fatty acid consisting of the normal-, anteiso-, and iso- branched isomers. The surface activity of the B. licheniformis JF-2 surfactant was shown to depend on the presence of fermentation products and is strongly affected by the pH. Under conditions of optimal salinity and pH the interfacial tension against decane was 6 [times] 10[sup 3] mN/m which is one of the lowest values ever obtained with a microbial surfactant. Microbial compounds which exhibit particularly high surface activity are classified as biosurfactants. Microbial biosurfactants include a wide variety of surface and interfacially active compounds, such as glycolipids, lipopeptides polysaccharideprotein complexes, phospholipids, fatty acids and neutral lipids. Biosurfactants are easily biodegradable and thus are particularly suited for environmental applications such as bioremediation and the dispersion of oil spills. Bacillus licheniformis strain JF-2 has been shown to be able to grow and produce a very effective biosurfactant under both aerobic and anaerobic conditions and in the presence of high salt concentrations. The production of biosurfactants in anaerobic, high salt environments is potentially important for a variety of in situ applications such as microbial enhanced oil recovery. As a first step towards evaluating the commercial utility of the B. licheniformis JF-2 surfactant, we isolated t-he active. compound from the culture supernatant, characterized its chemical structure and investigated its phase behavior. We found that the surface activity of the surfactant is strongly dependent on the pH of the aqueous. phase. This may be important for the biological function of the surfactant and is of interest for several applications in surfactancy.
Endoscopic full-thickness biopsy of the gastric wall with defect closure by using an endoscopic suturing device: survival porcine study (2012)

FTGB by using the SEMF technique and an endoscopic suturing device is technically feasible, reproducible, and safe. Larger tissue specimens will allow improved analysis of multiple cell types.
The Lipid Flippases ALA4 and ALA5 Play Critical Roles in Cell Expansion and Plant Growth (2020)

Aminophospholipid ATPases (ALAs) are lipid flippases involved in transporting specific lipids across membrane bilayers. Arabidopsis (<i>Arabidopsis thaliana</i>) contains 12 ALAs in five phylogenetic clusters, including four in cluster 3 (ALA4-ALA7). <i>ALA4</i>/<i>5</i> and <i>ALA6</i>/<i>7</i>, are expressed primarily in vegetative tissues and pollen, respectively. Previously, a double knockout of <i>ALA6</i>/<i>7</i> was shown to result in pollen fertility defects. Here we show that a double knockout of <i>ALA4</i>/<i>5</i> results in dwarfism, characterized by reduced growth in rosettes (6.5-fold), roots (4.3-fold), bolts (4.5-fold), and hypocotyls (2-fold). Reduced cell size was observed for multiple vegetative cell types, suggesting a role for ALA4/5 in cellular expansion. Members of the third ALA cluster are at least partially interchangeable, as transgenes expressing <i>ALA6</i> in vegetative tissues partially rescued <i>ala4/5</i> mutant phenotypes, and expression of <i>ALA4</i> transgenes in pollen fully rescued <i>ala6/7</i> mutant fertility defects. ALA4-GFP displayed plasma membrane and endomembrane localization patterns when imaged in both guard cells and pollen. Lipid profiling revealed <i>ala4/5</i> rosettes had perturbations in glycerolipid and sphingolipid content. Assays in yeast revealed that ALA5 can flip a variety of glycerolipids and the sphingolipid sphingomyelin across membranes. These results support a model whereby the flippase activity of ALA4 and ALA5 impacts the homeostasis of both glycerolipids and sphingolipids and is important for cellular expansion during vegetative growth.
Band-Limited Trajectory Planning and Tracking for Certain Dynamically Stabilized Mobile Systems (2005)

In this paper, a general framework for trajectory planning and tracking is formulated for dynamically stabilized mobile systems, e.g., inverted wheeled pendulums and autonomous helicopters. Within this framework, the system state is divided into slow and fast substates. The fast substate is used as a pseudocontrol for tracking a desired slow substate trajectory. First, an exponential fast substate controller is designed to track a fast substate reference trajectory. This fast substate reference trajectory is, in turn, planned so that the slow substate follows its desired trajectory. To ensure that the fast substate reference trajectory is feasible for the exponential controller, it is designed using band-limited “Sinc” functions whose maximum frequency is less than the inverse of the time constant of the exponential controller. To illustrate the procedure, the dynamic model of an inverted wheeled pendulum is reformulated by a partial feedback linearization such that it is amenable to the separation into slow and fast components. The planning and tracking controller design is explained using simulation results. This technique is shown to be easily embedded inside a modified nonlinear model predictive control framework for the slow subsystem. This framework tries to explicitly take the computational delay into account. The computation time required for this technique is encouraging from a real-world implementation perspective.
Photosensitizer–Antibiotic Conjugates: A Novel Class of Antibacterial Molecules (2009)

Bacterial resistance to a variety of antibiotics has led to intensive research into the effect of photosensitizers as a cytotoxic agent against bacterial cells. In this study, we synthesized the following conjugates with or without a linker: rose bengal-penicillanic acid (RBPA), rose bengal-linker-penicillanic acid (RBLPA) and rose bengal-linker-kanamycin (RBLKAN). The antibacterial activity of these conjugates was examined on Staphylococcus aureus and Escherichia coli. Exposure of the cultures to 100 J cm(-2) showed that the minimum inhibitory concentration (MIC) of RBPA, RBLPA and RBLKAN on S. aureus was 0.195, 0.156 and 0.004 microm, respectively. The MIC of RBPA, RBLPA and RBLKAN on E. coli was 1.56, 2.5 and 0.156 microm, respectively. In dark control experiments, the MIC of these conjugates was not detected until a concentration that was 16-fold that of the MIC found in the light experiments. RBPA and RBLPA as well as RBLKAN are bactericidal for both bacterial cells. Total eradication of S. aureus and E. coli was observed with RBLKAN (0.078 and 20 microm 16 J cm(-2), respectively). Under these conditions, scanning electron microscopic analysis showed significant damage to these bacteria. However, the photosensitizer and antibiotics individually were not effective.