gebhart/patrepeval huggingface dataset:
Evaluation of pseudorandom sequences for third generation spread spectrum systems (2003)

Much research has been conducted on pseudorandom sequences used in spread spectrum systems. With the growing complexity of new systems, more sets of sequences need to be evaluated for their suitability in new applications, such as multi-rate code-division multiple access (CDMA) systems. Hence there is still a need for further study of these sequences. In our work, the performance of pseudo random sequences used in 3/sup rd/ generation spread spectrum systems has been analyzed statistically using auto and cross correlation properties of the sequences. The effect of pulse shape altering on the correlation properties has also been characterized.
Sequencing and Fingerprinting DNA by Hybridization with Oligonucleotide Probes (2000)

Abstract Sequencing by hybridization (SBH) determines the sequences of DNA or RNA targets using hybridization data obtained from sets of overlapping oligonucleotide probes of known sequence. SBH shares interesting parallels with computer‐based keyword searches of text files. In SBH, chemically synthesized short oligonucleotides (usually 4–25 bases in length) are hybridized to the target under conditions that predominantly allow formation of fully complementary probe/target hybrids. An oligonucleotide hybridization search is effectively a highly parallel molecular computation process with fully random access to the polynucleotide chain “input data”. The target sequence is assembled by aligning sequences of the subset of positively hybridizing oligonucleotides. Probe sequence overlap allows indirect assignment of which of four bases corresponds to each position in the analyzed DNA chain, without performing any actual positional measurements on the sample. The fundamental characteristics of the SBH process confer unique opportunities for miniaturization and parallel analyses (currently in the form of high‐density arrays), leading to rapid, cost‐effective DNA sequencing. A unique advantage of SBH is its ability to analyze in a single reaction complex DNA or RNA samples that may be thousands of bases long. Hybridization of smaller selected subsets of probes provides a very efficient way of partially sequencing and fingerprinting samples. A very important advantage of SBH is that in a single reaction each base is “read” by multiple overlapping probes. To achieve these advantages, hybridization reactions are miniaturized and coupled with automated data acquisition and efficient computational analyses that can process data sets containing both false‐positive and false‐negative probe scores. Successful assembly of long target sequences involves synthesis and hybridization of a large number of long probes, due to the higher probability that given short oligonucleotide sequences will be repeated within the target sequence. Overall, SBH is a rapid and cost‐effective method of obtaining large amounts of accurate DNA sequence information.
Singlet Fission in 9,10-Bis(phenylethynyl)anthracene Thin Films (2018)

Singlet fission (SF) in two or more electronically coupled organic chromophores converts a high-energy singlet exciton into two low-energy triplet excitons, which can be used to increase solar cell efficiency. Many known SF chromophores are unsuitable for device applications due to chemical instability and low triplet state energies. The results described here show that efficient SF occurs in polycrystalline thin films of 9,10-bis(phenylethynyl)anthracene (BPEA), a commercial dye that has singlet and triplet energies of 2.40 and 1.11 eV, respectively, in the solid state. BPEA crystallizes into two polymorphs with space groups C2/ c and Pbcn, which undergo SF with k<sub>SFA</sub> = (109 ± 4 ps)<sup>-1</sup> and k<sub>SFB</sub> = (490 ± 10 ps)<sup>-1</sup>, respectively. The high triplet energy and efficient SF evidenced from the 180 ± 20% triplet yield make BPEA a promising candidate for enhancing solar cell performance.
Aluminum Hydride (Alane) (2010)

This chapter contains sections titled: Introduction Hydrogen Solubility and Diffusivity in Aluminum Formation and Thermodynamics of Different Phases of Alane Stability and Formation of Adduct Organo-Aluminum Hydride Compounds Phases and Structures of Aluminum Hydride Novel Attempts and Methods for Forming Alane Reversibly Conclusion References
Supplementary Figure 1 from hTERT Is Expressed in Cancer Cell Lines Despite Promoter DNA Methylation by Preservation of Unmethylated DNA and Active Chromatin around the Transcription Start Site (2023)

Supplementary Figure 1 from hTERT Is Expressed in Cancer Cell Lines Despite Promoter DNA Methylation by Preservation of Unmethylated DNA and Active Chromatin around the Transcription Start Site
2‐Difluoromethoxy‐Substituted Estratriene Sulfamates: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Steroid Sulfatase Inhibition (2022)

2-Difluoromethoxyestratriene derivatives were designed to improve potency and in vivo stability of the drug candidate 2-methoxyestradiol (2ME2). Compound evaluation in vitro against the proliferation of MCF-7 and MDA MB-231 breast cancer cells, as inhibitors of tubulin polymerisation and also steroid sulfatase (STS) both in cell lysates and in whole cells, showed promising activities. In antiproliferative assays 2-difluoromethoxyestradiol was less potent than 2ME2, but its sulfamates were often more potent than their corresponding non-fluorinated analogues. The fluorinated bis-sulfamate is a promising antiproliferative agent in MCF-7 cells (GI<sub>50</sub> 0.28 μM) vs the known 2-methoxyestradiol-3,17-O,O-bissulfamate (STX140, GI<sub>50</sub> 0.52 μM), confirming the utility of our approach. Compounds were also evaluated in the NCI 60-cell line panel and the fluorinated bis-sulfamate derivative displayed very good overall activities with a sub-micromolar average GI<sub>50</sub> . It was a very potent STS inhibitor in whole JEG-3 cells (IC<sub>50</sub> 3.7 nM) similar to STX140 (4.2 nM) and additionally interferes with tubulin assembly in vitro and colchicine binding to tubulin. An X-ray study of 2-difluoromethoxy-3-benzyloxyestra-1,3,5(10)-trien-17-one examined conformational aspects of the fluorinated substituent. The known related derivative 2-difluoromethyl-3-sulfamoyloxyestrone was evaluated for STS inhibition in whole JEG-3 cells and showed an excellent IC<sub>50</sub> of 55 pM.
Effect of Probiotic Supplementation on Gut Microbiota in Patients with Major Depressive Disorders: A Systematic Review (2023)

There is accumulating evidence on the beneficial effects of probiotic supplementation for patients with depressive disorders. However, prior reviews on the topic have largely focused on clinical effectiveness with limited emphasis on the underlying mechanisms of action and effects of probiotics on gut microbiota. In accordance with PRISMA guidelines, a systematic literature search of Medline, EMBASE and the Cochrane Library using combinations of the key words, ("depress*" OR "MDD" OR "suicide"), ("probiotic" OR "Lactobacillus" OR "Bifidobacterium") AND ("gut" OR "gut micr*" OR "microbiota"), as well as grey literature was performed. We found seven clinical trials involving patients with major depressive disorder (MDD). The small number of studies and heterogeneous sources of data precluded meta-analysis. Most trials (other than one open-label trial) had a low-to-moderate risk of bias, which was largely due to a lack of control for the effects of diet on gut microbiota. Probiotic supplementation yielded only modest effects on depressive symptoms and there were no consistent effects on gut microbiota diversity, and in most instances, no significant alterations in gut microbiota composition were observed after four to eight weeks of probiotic intervention. There is also a lack of systematic reporting on adverse events and no good longer-term data. Patients with MDD may require a longer time to show clinical improvement and the microbial host environment may also need longer than eight weeks to produce significant microbiota alterations. To advance this field, further larger-scale and longer-term studies are required.
Fasting-Induced Hepatic Production of DHEA Is Regulated by PGC-1α, ERRα, and HNF4α (2009)

The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha is involved in the coordinate induction of changes in gene expression in the liver that enable a homeostatic response to alterations in metabolic state, environmental cues, and nutrient availability. In exploring the specific pathways under PGC-1alpha regulation in the liver, we have made the surprising observation that this coactivator can induce the expression of CYP11A1 and CYP17A1, key rate-limiting enzymes involved in the initial steps of steroidogenesis. Both of these enzymes function to produce C(19)-steroids, converting cholesterol into pregnenolone, and then to dehydroepiandrosterone (DHEA). Estrogen-related receptor (ERR)-alpha mediates PGC-1alpha's induction of CYP11A1 and binds within the first intron of the CYP11A1 gene. Both ERR-alpha and hepatocyte nuclear factor-4alpha are required for PGC-1alpha-mediated induction of CYP17A1, and specific binding sites for these receptors have been identified in the regulatory regions of this gene. The potential physiological significance of these observations was highlighted in rats where fasting induced hepatic expression of PGC-1alpha and CYP17A1 and was associated with an increase in hepatic levels of DHEA. These data suggest that DHEA could be playing a role as an intracellular signaling molecule involved in modulating hepatic activity in response to fasting conditions.
Abstract 17073: Intraprocedural Use of Dopamine During Ventricular Tachycardia (VT) Ablation is Associated With Greater Number of VTs Induced and Increased Need for Cardioversions (2018)

Introduction: Hemodynamic drugs are frequently used in patients with heart failure, despite arrhythmogenic effects. In certain situations, dopamine has been associated with increased arrhythmias and mortality. There are no known studies reviewing the impact of hemodynamic drugs used during VT ablations on procedural outcomes. Hypothesis: We sought to determine whether intra-procedural use of dopamine, dobutamine, or phenylephrine affected the number of induced VTs, required cardioversions, or the acute success of VT ablations. Methods: We conducted a retrospective review for all VT ablations from 2013-17 at our institution. Patient and procedural details were collected for 149 VT ablations. Results: The cohort was 81% male, and 67% had cardiomyopathy of which 53% were ischemic with a mean EF of 29.1% (CI 26.7- 31.4). Vasoactive drugs were used in 87% of patients undergoing VT ablation: phenylephrine (67%), dopamine (40%), dobutamine (37%). After adjusting for heart failure and procedural time, use of dopamine, but not phenylephrine or dobutamine, was associated with a greater number of induced VTs (p =0.02, Fig. 1a). Adjusting for the same factors, dopamine and dobutamine were significantly associated with increased need for cardioversions (p &lt; 0.01). Dobutamine, but not dopamine or phenylephrine, was associated with lower acute procedural success (OR 0.25, CI 0.08-0.77, P = 0.01). Conclusions: Different vasoactive drugs may have differential effects on VT ablation outcomes. The focus of VT ablation is usually on VT mechanism and substrate, but attention to other factors, such as vasoactive drugs, may be warranted to determine their effect on procedural outcomes.
Beam Pattern Synthesis in the Presence of Interference and Multipath (2006)

In this paper, an improved beampattern synthesis technique based on generalized sidelobe canceller (GSC) structure is proposed. Constrained optimization algorithm is used to control the beampattern from the main beam. Instead of selecting the blocking matrix in the noise subspace which is orthogonal to the signal-plus-interference subspace, we use the cyclostationary property of the transmitting signals to ensure that the blocking matrix spans the interference-plus-noise subspace. This can help us to get a better control of the beampattern, especially in the interference-limited and time-varying environment and when the interference is close to the look direction. We also consider the case when multipath signals exist along with the desired signal, and put forward an improved structure to solve this problem. Numerical results show that compared with other GSC-based structures, our proposed beampattern synthesis technique is able to reject strong directional interferences and multipath signal.
The Challenge Presented by Progestins in Ecotoxicological Research: A Critical Review (2015)

Around 20 progestins (also called gestagens, progestogens, or progestagens) are used today in assisting a range of medical conditions from endometrial cancer to uterine bleeding and as an important component of oral contraception. These progestins can bind to a wide range of receptors including progestin, estrogen, androgen, glucocorticoid, and mineralocorticoid receptor, as well as sex hormone and corticosteroid binding globulins. It appears that only five of these (four synthetic and one natural) progestins have so far been studied in sewage effluent and surface waters. Analysis has reported values as either nondetects or low nanograms per liter in rivers. Seven of the progestins have been examined for their effects on aquatic vertebrates (fish and frogs). The greatest concern is associated with levonorgestrel, norethisterone, and gestodene and their ability to reduce egg production in fish at levels of 0.8-1.0 ng/L. The lack of environmental measurements, and some of the contradictions in existing values, however, hampers our ability to make a risk assessment. Only a few nanograms per liter of ethynodiol diacetate and desogestrel in water would be needed for fish to receive a human therapeutic dose for these progestins according to modeled bioconcentration factors. But for the other synthetic progestins levels would need to reach tens or hundreds of nanograms per liter to achieve a therapeutic dose. Nevertheless, the wide range of compounds, diverse receptor targets, and the effect on fish reproduction at sub-nanogram-per-liter levels should prompt further research. The ability to impair female reproduction at very low concentrations makes the progestins arguably the most important pharmaceutical group of concern after ethinylestradiol.
Simultaneous Detection of SERS and Fluorescence Using a Single Excitation for Microbead-Based Analysis (2013)

We demonstrate simultaneous detection of surface-enhanced Raman scattering (SERS) and fluorescence signals from a silver microbead. For the dual signal generation, silver microbeads with a diameter of 15 microm were functionalized with benzenethiol (BT) as a Raman tag and a cardiac troponin I (cTnI) antibody on their surface. SERS and fluorescence signals were obtained using a single argon laser source with 488 nm wavelength. The SERS signals from Raman tag can be used as identification indices for decoding a particular microbead, while the fluorescence signals provide the information about molecular interactions with a specific biomarker. With simultaneous detection of SERS and fluorescence signals using single excitation on the functionalized microbeads, we successfully showed the possibility of a simple barcoding strategy for multiplex analysis using suspension arrays.
Triboluminescence of sugars (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTriboluminescence of sugarsJeffrey I. Zink, Gordon E. Hardy, and James E. SuttonCite this: J. Phys. Chem. 1976, 80, 3, 248–249Publication Date (Print):January 1, 1976Publication History Published online1 May 2002Published inissue 1 January 1976https://pubs.acs.org/doi/10.1021/j100544a007https://doi.org/10.1021/j100544a007research-articleACS PublicationsRequest reuse permissionsArticle Views757Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A DOI PET detector having extended X'tal cube structure (2010)

We developed a new PET depth-of-interaction (DOI) detector in which the scintillation crystal array is extended in one direction. It can be utilized as a PET detector having, for instance, long axial direction. The detector has the "crystal cube (X'tal cube)" structure and the extension was enabled by the feature of the X'tal cube that some MPPCs are always placed close to an originating position of the scintillation photons. X'tal cube is a DOI PET detector we have developed and it can provide isotropic spatial resolution. X'tal cube consists of a scintillation crystal block segmented into cubes and multi-pixel photon counters (MPPCs). A number of MPPCs are coupled on all six sides of the crystal block to detect scintillation photons near their originating position. In a preliminary experiment previously carried out, we confirmed sufficient detector performance of X'tal cube using a prototype composed of a 6 × 6 × 6 array of Lu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2S</sub> Gd <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ( <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-S</sub> )SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> :Ce (LGSO, x=0.9) crystals with dimensions of 3.0 × 3.0 × 3.0 mm and MPPCs of 3.0 × 3.0 mm active area. In this study, the crystal block was extended in one direction from 6 crystals to 14 crystals. The results of performance evaluation proved that the 6 × 6 × 14 crystals could be identified with the structure. Although MPPCs were coupled on all sides of the crystal block in the extended X'tal cube, at the central part, the detected radiation position would be calculated with mainly the signals of close MPPCs on the four surfaces. That means the detector can be long as considered appropriate for a system while keeping the isotropic spatial resolution.
Nonideal Conductor Models (2008)

This chapter contains sections titled: Signals Propagating in Unbounded Conductive Media Classic Conductor Model for Transmission Lines Surface Roughness Transmission-Line Parameters for Nonideal Conductors References Problems
Understanding Fluorine Effects in Liquid Crystals (2009)

Stabilized by fluorine: For the first time a conclusive explanation for the beneficial effects of fluorine in aliphatic bridges within the mesogenic core structure of nematic liquid crystals is offered. A combination of steric and stereoelectronic effects stabilizes rod-like conformations (see pciture) which are essential for the formation of the nematic phase. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
caliPER: A software for blood-free parametri c P a t l ak mapp i ng using PE T/M R I input function (2021)

Abstract Routine clinical use of absolute PET quantification techniques is limited by the need for serial arterial blood sampling for input function and more importantly by the lack of automated pharmacokinetic analysis tools that can be readily implemented in clinic with minimal effort. PET/MRI provides the ability for absolute quantification of PET probes without the need for serial arterial blood sampling using image-derived input functions (IDIFs). Here we introduce caliPER, a modular and scalable software for simplified pharmacokinetic modelling of PET probes with irreversible uptake or binding based on PET/MR IDIFs and Patlak Plot analysis. caliPER generates regional values or parametric maps of net influx rate ( K i ) using reconstructed dynamic PET images and anatomical MRI aligned to PET for IDIF vessel delineation. We evaluated the performance of caliPER for blood-free region-based and pixel-wise Patlak analyses of [ 18 F] FDG by comparing caliPER IDIF to serial arterial blood input functions and its application in imaging brain glucose hypometabolism in Frontotemporal dementia. IDIFs corrected for partial volume errors including spill-out and spill-in effects were similar to arterial blood input functions with a general bias of around 6-8%, even for arteries &lt;5 mm. The K i and cerebral metabolic rate of glucose estimated using caliPER IDIF were similar to estimates using arterial blood sampling (&lt;2%) and within limits of whole brain values reported in literature. Overall, caliPER is a promising tool for irreversible PET tracer quantification and can simplify the ability to perform parametric analysis in clinical settings without the need for blood sampling. Highlights caliPER is an adaptable image processing software for extracting image-derived input functions and generating parametric maps of irreversible PET tracer uptake. Anatomical (T1-weighted/T2-weighted/time-of-flight angiography) MRI carefully aligned to PET provides a robust approach for delineation of vessels on PET, eliminating the need for serial blood sampling for input functions. Application of caliPER in modelling glucose uptake in patients with Frontotemporal dementia, demonstrates the feasibility of absolute quantification of cerebral metabolic rate of glucose in clinical populations.
Read/write simulation of Ba-ferrite particulate media (1991)

A M-H loop model for Ba-ferrite particulate media is introduced where a modified Stoner–Wohlfarth model is used as a magnetization reversal model. It is confirmed that this model can be applied for read/write simulation of Ba ferrite. Using this model, the read/write performance of Ba-ferrite media is investigated and compared with that of acicular particulate media. The results indicate that: (i) For high-density recording, longitudinally oriented Ba ferrite is superior to acicular particulate media because of its high coercive squareness S*; (ii) to improve read/write performance of the Ba-ferrite in use today, narrowing of anisotropy field distribution is effective; and (iii) perpendicularly oriented Ba ferrite has good read/write performance only at narrow head-medium spacings.
Simulated space environmental effects on some experimental high performance polymers (1991)

High performance polymers for potential space applications were evaluated under simulated space environmental conditions. Experimental resins from blends of acetylene terminated materials, poly(arylene ether)s and low color polyimides were exposed to high energy electron and ultraviolet radiation in an attempt to simulate space environmental effects. Thin films, neat resin moldings, and carbon fiber reinforced composites were exposed, and the effect on certain polymer properties were determined. Recent research involving the effects of various radiation exposures on the physical, optical, and mechanical properties of several experimental polymer systems is reviewed.