gebhart/patrepeval huggingface dataset:
[Neprilysin inhibition and chronic kidney disease]. (2017)

Patients with chronic kidney disease (CKD) have a higher incidence of cardiovascular (acute and chronic) events, which in turn have an increased risk of progression to end-stage renal disease (ESRD) Inhibition of neprilysin, in addition to offering a new therapeutic target in patients with heart failure, could represent a potential improvement strategy in cardiovascular and renal outcome of patients with CKD. Inhibition of neprilysin by inhibiting the breakdown of natriuretic peptides, increases their bioavailability resulting in an increase in diuresis and sodium excretion and, in addition to exerting an inhibition of the renin-angiotensin-aldosterone (RAAS) system. Inhibition of RAAS, in turn, generates a series of counter-regulations that can balance the adverse effects present in CKD and heart failure (HF). The idea of blocking neprilysin is not very recent, but the first drugs used as inhibitors had an inadmissible incidence of angioedema. Among the latest generation molecules that can perform a specific inhibitory action on the neprilysin receptor and, at the same time, on the angiotensin II receptor thanks to the association with valsartan there is the LCZ696 (sacubitril / valsartan). This drug has shown promising benefits both in the treatment arterial hypertension and heart failure. It is hoped that equally positive effects may occur in CKD patients, particularly those with macroproteinuria.
Allogeneic CD20‐targeted γδ T cells exhibit innate and adaptive antitumor activities in preclinical B‐cell lymphoma models (2022)

These preclinical data support the clinical evaluation of ADI-001, an allogeneic CD20 CAR<sup>+</sup> Vδ1 γδ T cell, and a phase 1 study has been initiated in patients with B-cell malignancies (NCT04735471).
Novel Organosoluble Poly(pyridine−imide) with Pendent Pyrene Group:  Synthesis, Thermal, Optical, Electrochemical, Electrochromic, and Protonation Characterization (2007)

A new diamine containing a pyridine heterocyclic group and a pyrene substituent, 4-(1-pyrene)-2,6-bis(4-aminophenyl)pyridine (PBAPP), was synthesized and used in a preparation of poly(pyridine−imide) by direct polycondensation with 4,4‘-hexafluoroisopropylidenediphathalic anhydride (6FDA) in N-methyl-2-pyrrolidinone (NMP). The poly(pyridine−imide) derived from diamine (PBAPP) was highly soluble in several solvents such as THF, NMP, DMAc, DMF, pyridine, DMSO, and cyclohexanone at room temperature or upon heating at 70 °C and exhibited good thermal stability both in nitrogen and air (Td10>520 °C) and a high dielectric constant of 4.32 at 1 kHz. The poly(pyridine−imide) could be cast into a flexible and tough film from DMAc solution. The poly(pyridine−imide) film had a tensile strength of 118 MPa and a tensile modulus of 2.2 GPa. The optical properties exhibited the UV−vis absorption bands at the region of 200−400 nm and possessed strong orange fluorescent (560 nm) after protonated with protic acid.
Adaptive map configuration and dynamic routing to optimize the performance of a satellite communication network (2002)

It is demonstrated that the performance of a satellite network can be optimized by changing its facilities. A mesh-connected, circuit-switched satellite communication network is shown to perform better by adaptively reconfiguring the network by using simulated annealing to suit the current traffic conditions. Proper allocation of link capacities and placing an optimal reservation scheme for the network are crucial in this scheme. Routing is performed dynamically. Simulation results confirm these characteristics.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Behavior of n-type and p-type silicon in anhydrous liquid ammonia. The solvated electron generation: a supra-band-edge reaction (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBehavior of n-type and p-type silicon in anhydrous liquid ammonia. The solvated electron generation: a supra-band-edge reactionMichael Herlem, D. Guyomard, C. Mathieu, J. Belloni, and J. L. SculfortCite this: J. Phys. Chem. 1984, 88, 17, 3826–3833Publication Date (Print):August 1, 1984Publication History Published online1 May 2002Published inissue 1 August 1984https://pubs.acs.org/doi/10.1021/j150661a028https://doi.org/10.1021/j150661a028research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Self-Management for Unified Heterogeneous Radio Access Networks (2013)

The development of self-management solutions for (multi-technology, multi-layer) mobile communication networks is driven by their increasing operational complexity. Initial stand-alone SON (Self-Organizing Networks) solutions are already available, but are not sufficient to handle the networks of tomorrow. In this paper we present our approach at developing a unified management framework that integrates the existing and future advanced SON functions across several radio access technologies. The envisioned self-management system comprises (i) an integrated SON management system, in charge of policy transformation/supervision and conflict detection/handling; (ii) advanced multi-RAT/layer SON functions; and (iii) a Decision Support System providing measurement-based assistance for residual operational tasks, such as timely recommendations for targeted new site deployments.
ChemInform Abstract: POLYMER‐BASED SENSITIZERS FOR PHOTOCHEMICAL REACTIONS. SILICA GEL AS A SUPPORT (1980)

Abstract Das, wie im Formelschema skizziert, hergestellte silylierte Kieselgel (III) wird mit Bengalrosa (IV) zum Derivat (V) umgesetzt.
CMOS-Compatible Wearable Sensors Fabricated Using Controlled Spalling (2019)

Wearable sensors can provide important human physiology and activity data and therefore have promising applications in healthcare, entertainment, and security. Here, we report the design, fabrication, and characterizations of a thin silicon film sensor for wearable sensor applications. Temperature, light, and strain sensing capabilities of the thin film of doped silicon, fabricated using a controlled spalling process, were fully characterized. An n-doped silicon thin-film sensor prepared with the spalling technology exhibited a temperature coefficient of -0.44%/°C. The sensor also showed excellent light sensing response in an illumination range from 110 to 1710 cd/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The ratio of the electrical resistance changes over the applied forces was measured to be around 0.6%/N.
Biomimetic Approaches to Control Soluble Concentration Gradients in Biomaterials (2011)

Soluble concentration gradients play a critical role in controlling tissue formation during embryonic development. The importance of soluble signaling in biology has motivated engineers to design systems that allow precise and quantitative manipulation of gradient formation in vitro. Engineering techniques have increasingly moved to the third dimension in order to provide more physiologically relevant models to study the biological role of gradient formation and to guide strategies for controlling new tissue formation for therapeutic applications. This review provides an overview of efforts to design biomimetic strategies for soluble gradient formation, with a focus on microfluidic techniques and biomaterials approaches for moving gradient generation to the third dimension.
No association of anti-Chlamydia trachomatis antibodies and severity of cervical neoplasia (2001)

Our results suggest that the presence of circulating antichlamydial antibodies is not associated with the severity of neoplastic lesions and it seems unlikely that C trachomatis has a role in the progression of cervical neoplasia.
Highly Entangled α-Olefin Molecular Bottlebrushes: Melt Structure, Linear Rheology, and Interchain Friction Mechanism (2018)

Linear viscoelastic response and melt microstructure of ultra-high molecular weight poly(α-olefins) (UHMW PO) with bottlebrush architectures, from poly(1-hexene) to poly(1-octadecene) synthesized by metal coordinative insertion polymerization, were measured as a function of side-chain length, Nsc. All these bottlebrush POs are highly entangled, with an average number of entanglements per chain, Z, greater than 50, which allows accurate determination of their rubbery plateau moduli, GN0, and their entanglement molecular weights, Me. Their plateau moduli scale with their side-chain lengths as GN0 ∼ Nsc–1.47, in agreement with the scaling theory for the dense bottlebrush limit that predicts GN0 ∼ Nsc–3/2. Melt structures of these bottlebrush poly(1-olefin)s and their melt structural changes with temperature were determined by wide-angle X-ray scattering. Concomitant with thermal expansion of these bottlebrush PO melts is a nonmonotonic change in backbone-to-backbone distance (d1) and a monotonic increase in side-chain spacing (d2). Both the melt-flow interchain friction coefficient and the viscosity of these UHMW PO bottlebrushes show a very strong dependence on d2, characterized by two exponential decay regimes, with decay constants having an exponential dependence on Nsc.
Hormone-resistant endometriosis following total abdominal hysterectomy and bilateral salpingo-oophorectomy: correlation with histology and steroid receptor content. (1991)

Endometriosis is rare after hysterectomy and oophorectomy for conditions unrelated to endometriosis. We present a case of delayed development of aggressive, hormone-resistant endometriosis temporally remote from hysterectomy and oophorectomy performed for chronic pelvic inflammatory disease. Treatment with depo-medroxyprogesterone acetate resulted in continued growth of the retroperitoneal endometrioma and necessitated posterior exenteration because of the endometrioma's location. Estrogen and progesterone receptor levels were measured to clarify why this woman's endometriosis was resistant to hormone therapy. Despite administration of large amounts of depo-medroxyprogesterone acetate, the progesterone receptor content was elevated while the estrogen receptor content was undetectable. Why this patient developed this particular type of aggressive endometriosis is unclear, but the lack of down-regulation of progesterone receptors in response to high-dose progestin therapy may indicate an alteration in basic regulatory and cellular processes within the endometriotic implant.
Iron uptake by rat duodenal microvillous membrane vesicles: evidence for a carrier mediated transport system (1987)

The mechanism of iron translocation from intestinal lumen to portal plasma is poorly understood. To examine these processes, uptake of Fe2+ and Fe3+ by rat duodenal microvillous membrane vesicles prepared by a Ca2+ precipitation procedure was studied. Membrane aliquots were incubated with increasing concentrations of 59FeCl3 in the presence of a one-thousand-fold molar excess of citrate or 59FeSO4 with a twenty-fold molar excess of L-ascorbic acid. After various time intervals the incubation reaction was stopped by addition of 0.1 mM FeCl3 (4 degrees C), and uptake of 59Fe was determined by a vacuum filtration assay. Initial uptake velocity of 59FeCl3 and 59FeSO4 was determined from the slope of the cumulative uptake curves, which was linear for the first 60 s. Initial uptake rates of both, 59Fe3+ and 59Fe2+ revealed an identical saturable uptake component with a Km of 19-22 nM and Vmax of 8 pmol min-1 mg protein-1. In addition, transport of Fe2+ revealed a linear unspecific uptake phase, which was predominant at high substrate concentrations. Saturable uptake of Fe2+ and Fe3+ was temperature dependent, and significantly reduced by trypsin pretreatment of the microvillous membrane vesicles, indicating the involvement of a protein in the uptake process. This suggestion was pursued by isolation of an iron binding protein from duodenal brushborder membranes. After solubilization of microvillous plasma membranes with 1% Triton X 100, affinity chromatography of the membrane protein mixture over an iron chelate gel derived from epoxy activated Sepharose and elution with 50 mM EDTA yielded a single 52,000 dalton protein. The protein co-chromatographed over an Ultro-Pac TSK G 3000SW HPLC column together with 59FeCl3 and 59FeSO4. It showed no immunologic activity to rabbit antibodies against whole rat serum or rat transferrin. Furthermore, by photoaffinity labelling technique a single iron binding protein with a molecular weight of about 52,000 dalton was identified in microvillous membranes of the rat duodenum. These data are compatible with the hypothesis that intestinal iron absorption is mediated by a specific carrier-dependent transport system.
Expression of COX-1 and COX-2 mRNAs in atherosclerotic plaques (2002)

Inflammation is a characteristic of atherosclerotic plaques. Prostaglandins are inflammatory mediators whose production is controlled by cyclooxygenase (COX). There are two isoforms: COX-1 and COX-2. COX-1 is relatively stable while COX-2 is induced in inflammatory states. In order to evaluate their possible contribution to atherosclerotic plaque inflammation, we measured their relative levels in postmortem plaque and adjacent normal arterial tissue. Eleven pairs of atherosclerotic plaque and adjacent normal arterial tissue were obtained from postmortem specimens. Total RNA was extracted and relative levels of COX-1 and COX-2 determined by the technique of RT-PCR. COX-2 levels were 4.8-fold higher in plaque tissue than in normal artery. COX-1 levels were only 1.1-fold higher. There was no relationship between sex, age, postmortem delay or cause of death and COX-2 or COX-1 levels. COX-2 levels are sharply upregulated in atherosclerotic plaques, indicating that it may be a significant contributor to plaque inflammation. Accordingly, COX-2 inhibitors may reduce the degree of inflammation and protect against future cardiovascular events.
SSupplementary Figure 1 from Toll-like Receptor Agonist Imiquimod Facilitates Antigen-Specific CD8<sup>+</sup> T-cell Accumulation in the Genital Tract Leading to Tumor Control through IFNγ (2023)

&lt;p&gt;PDF file - 70K, E7-specific T cells efficiently migrated from circulation to the genital tract following imiquimod application.&lt;/p&gt;
Old and New C1-Symmetric Group 4 Metallocenes {(R1R2C)-(R2′R3′R6′R7′-Flu)(3-R3-5-R4-C5H2)}ZrCl2: From Highly Isotactic Polypropylenes to Vinyl End-Capped Isotactic-Enriched Oligomers (2012)

Chiral racemic, sterically crowded fluorene–cyclopentadiene derivatives having a monoaryl-substituted methylene bridge, (R1R2C)-((R2′,R3′,R6′,R7′-Flu)H)(3-R3-5-R4-C5H3) (2a–f), or an unsubstituted (nonstereogenic) isopropylidene bridge (2g) were synthesized via nucleophilic additions onto substituted fulvenes. The corresponding dichlorozirconocene complexes, namely, {Ph(H)C-(Flu)(3-tBu-5-Me-C5H2)}ZrCl2 (3a), {Ph(H)C-(3,6-tBu2Flu)(3-tBu-5-Et-C5H2)}ZrCl2 (3b), {Ph(H)C-(3,6-tBu2Flu)(3-tBu-5-Ph-C5H2)}ZrCl2 (3c), {Ph(H)C-(2,7-tBu2Flu)(3-tBu-5-Me-C5H2)}ZrCl2 (3d), {Ph(H)C-(Oct)(3-tBu-5-Me-C5H2)}ZrCl2 (3e) (Oct = octamethyloctahydrodibenzofluorenyl), {Ph(H)C-(Oct)(3-tBu-5-Et-C5H2)}ZrCl2 (3f), and {Me2C-(3,6-tBu-Flu)(3-tBu-5-Me-C5H2)}ZrCl2 (3g), were prepared in 10–91% yields. Complexes 3a–f, in which the most bulky phenyl substituent in the methylene bridge is anti to the 5-R substituent in the Cp ring, were isolated diastereomerically pure and characterized by elemental analysis, NMR spectroscopy, and X-ray crystallography. Among them, metallocenes 3b, 3e, and 3f, upon activation with MAO, proved highly active (14 330–34 470 kg(PP)·mol(Zr)−1·h–1) in the polymerization of propylene at 60 °C in toluene, yielding highly isotactic polypropylenes (iPP) with [m]4 up to 94.1% and Tm up to 152 °C. At elevated temperatures (80–100 °C), these {R1R2C-(Flu)(Cp)} catalysts produce isotactic-enriched oligomers having both vinyl and vinylidene end-groups arising from β-Me elimination and β-H elimination/transfer to monomer, respectively. The catalytic system 3c/MAO showed the highest vinyl selectivity, with up to 66% of vinyl chain-ends at 80 °C.
Overexpression of a Hyperpolarization-Activated Cation Current (Ih) Channel Gene Modifies the Firing Activity of Identified Motor Neurons in a Small Neural Network (2003)

The hyperpolarization-activated cation current (Ih) is widely distributed in excitable cells. Ih plays important roles in regulation of cellular excitability, rhythmic activity, and synaptic function. We previously showed that, in pyloric dilator (PD) neurons of the stomatogastric ganglion (STG) of spiny lobsters, Ih can be endogenously upregulated to compensate for artificial overexpression of the Shal transient potassium channel; this maintains normal firing properties of the neuron despite large increases in potassium current. To further explore the function of Ih in the pyloric network, we injected cRNA of PAIH, a lobster gene that encodes Ih, into rhythmically active PD neurons. Overexpression of PAIH produced a fourfold increase in Ih, although with somewhat different biophysical properties than the endogenous current. Compared with the endogenous Ih, the voltage for half-maximal activation of the PAIH-evoked current was depolarized by 10 mV, and its activation kinetics were significantly faster. This increase in Ih did not affect the expression of IA or other outward currents. Instead, it significantly altered the firing properties of the PD neurons. Increased Ih depolarized the minimum membrane potential of the cell, reduced the oscillation amplitude, decreased the time to the first spike, and increased the duty cycle and number of action potentials per burst. We used both dynamic-clamp experiments, injecting the modeled PAIH currents into PD cells in a functioning STG, and a theoretical model of a two-cell network to demonstrate that the increased Ih was sufficient to cause the observed changes in the PD activity.
Model-based metrology of resist patterns in lithography (2011)

A model-based optical metrology concept is presented that can be used for measuring the shape and position of resist features in the production of Memory and Logic devices. A few application examples are presented that demonstrate the capabilities of this concept.
Chloro, Alkyl and Aryl Complexes of Rare Earth Metals Supported by Bulky Tetrasubstituted Guanidinate Ligands (2005)

Abstract The reactions of anhydrous LnCl 3 (Ln = Y, Nd, Sm, Lu) with two equiv. of sodium N , N′ ‐dicyclohexyl‐ N′′ ‐bis(trimethylsilyl)guanidinate Na[(Me 3 Si) 2 NC(NCy) 2 ], obtained from Na[N(SiMe 3 ) 2 ] and the 1,3‐dicyclohexyl‐substituted carbodiimide CyN=C=NCy in THF, yield the monochloro bis(guanidinate) tetrahydrofuranate complexes [(Me 3 Si) 2 NC(NCy) 2 ] 2 LnCl(THF) [Ln = Y ( 1 ), Nd ( 2 ), Sm ( 3 ) and Lu ( 4 )]. The analogous reactions of YCl 3 and LuCl 3 with the lithium guanidinate [Li(Et 2 O)][(Me 3 Si) 2 NC(NCy) 2 ] afford the bis(guanidinate) “ate” complexes [(Me 3 Si) 2 NC(NCy) 2 ] 2 Ln(μ‐Cl) 2 Li(THF) 2 [Ln = Y ( 5 ) and Lu ( 6 )]. Treatment of 5 with dimethoxyethane results in the formation of [(Me 3 Si) 2 NC(NCy) 2 ] 2 Y(μ‐Cl) 2 Li(DME) ( 7 ). The carbyl complexes [(Me 3 Si) 2 NC(NCy) 2 ] 2 Y‐ t Bu] ( 8 ), [(Me 3 Si) 2 NC(NCy) 2 ] 2 Y(μ‐Me) 2 Li(TMEDA) ( 10 ) and [(Me 3 Si) 2 NC(NCy) 2 ] 2 YPh(THF) ( 13 ) were obtained by interaction of complex 1 with RLi (R = t Bu, Me or Ph). The molecular structures of 1 , 6 , 7 , 8 and the side product [Li(TMEDA)][(Me 3 Si) 2 NC(NCy) 2 ] have been determined by single‐crystal X‐ray analyses. Agostic interactions between the yttrium atom and the tert ‐butyl group in complex 8 in the solid state as well as in solution have been substantiated by 13 C NMR spectroscopy and X‐ray analysis. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2006)
Human Fibrinogen Inhibits Amyloid Assembly of Most Phenol-Soluble Modulins from Staphylococcus aureus (2021)

Functional amyloids are highly organized protein/peptide structures that <i>inter alia</i> promote biofilm formation in different bacteria. One such example is provided by a family of 20-45 residue-long peptides called phenol-soluble modulins (PSMs) from <i>Staphylococcus aureus</i>. External components such as eukaryotic host proteins, which alter self-assembly of bacterial amyloids, can affect the biofilm matrix. Here, we studied the effect of the highly prevalent human plasma protein fibrinogen (Fg) on fibrillation of PSMs. Fg inhibits or suppresses fibrillation of most PSMs tested (PSMα1, PSMβ1, and PSMβ2) except for PSMα3, whose already rapid aggregation is accelerated even further by Fg but leads to amorphous β-rich aggregates rather than fibrils. Fg also induces PSMβ2 to form amorphous aggregates and diverts PSMα1 into off-pathway oligomers which consist of both Fg and PSMα1 and cannot seed fibrillation. Peptide arrays showed that Fg bound to the N-terminus of PSMα1, while it bound to the entire length of PSMα3 (except the C terminus) and to the C-termini of PSMβ1 and PSMβ2. The latter peptides are all positively charged, while Fg is negatively charged at physiological pH. The positive charges complement Fg's net negative charge of -7.6 at pH 7.4. Fg's ability to inhibit PSM fibrillation reveals a potential host-defense mechanism to prevent bacterial biofilm growth and infections in the human body.
MAC-PDU Size Optimization for OFDMA Modulated Wireless Relay Networks (2008)

Hop adaptive MAC-PDU (Protocol Data Unit) size optimization is proposed for Orthogonal Frequency Division Multiple Access (OFDMA) based wireless relay networks. Such optimization improves the end-to- end goodput via MAC-PDU size optimization. We provide design and evaluation for two hop cellular networks with fixed relays where the Base Station (BS) to Relay Station (RS) links are potentially robust and are Line of Sight (LOS). The proposal reduces the total overhead transmitted in the end-to-end path via transmitting longer length packets in the potentially robust BS-to-RS links. The link level simulations show that, the reductions in overhead that consists of header and tailer is 25% to 44%. The system level investigations in a multi-user environment with a total of 3 relays in the cell show an average end-to-end goodput gain of 13%.