gebhart/patrepeval huggingface dataset:
Developmental hierarchy during early human B-cell ontogeny after autologous bone marrow transplantation using autografts depleted of CD19+ B-cell precursors by an anti-CD19 pan-B-cell immunotoxin containing pokeweed antiviral protein (1992)

Sequential immunophenotypes of bone marrow (BM) and peripheral blood (PBL) lymphoid cells from 15 B-lineage acute lymphoblastic leukemia (ALL) patients who underwent autologous bone marrow transplantation (BMT) during complete remission were determined by dual-color immunofluorescence and multiparameter flow cytometry. Autografts were depleted of CD19+ B-cell precursors by an immunochemopurging protocol that combines B43-PAP, a potent anti-CD19 immunotoxin, and the cyclophosphamide congener 4-hydroperoxycyclophosphamide (4-HC). A marked interpatient variation was observed in the appearance and expansion of B-cell precursors repopulating the posttransplant marrow. The expression of CD10 and CD19 antigens during early B-cell ontogeny post-BMT preceded the expression of CD20, CD21, CD22, CD40, and sIgM. The surface antigen profiles of the emerging B-cell precursors were similar to those of fetal liver or fetal bone marrow B-cell precursors. Our comparisons of BM and PBL samples from patients in the early post-BMT period demonstrated that (1) PBL initially contains fewer B-lineage cells than does BM, and (2) circulating B-lineage lymphoid cells have a more mature immunophenotype than do BM B-lineage lymphoid cells. Comparison of the surface antigen profiles of day 30 versus day 100 or year 1 BM or PBL lymphoid cells showed an increase in the percentages of CD10+CD22- undifferentiated lymphocyte precursors, as well as CD19+sIgM- B-cell precursors (pre-pre-B), consistent with a time-dependent expansion of these B-cell precursor populations post-BMT. Importantly, the percentages of CD10+CD22+ and CD19+sIgM+ B-cell precursor (pre-B) populations also increased between 30 days and 1 year post-BMT, confirming the ability of emerging immature B-cell precursors to differentiate along the B-precursor pathway. The acquisition and expression of B-lineage differentiation antigens at different stages of the post-BMT B-cell ontogeny support the notion that the expression of these antigens is developmentally programmed. Similar to patients in previous autologous BMT studies, recipients of B-cell precursor-depleted autografts had normal or nearly normal serum immunoglobulin levels, suggesting that the maturing B-cell/plasma cell populations can produce and secrete immunoglobulins. The development of a functional CD19+ B-lineage lymphoid compartment in recipients of autografts which were depleted of CD19+ B-cell precursors corroborates the previously postulated existence of CD19- B-lineage lymphoid progenitor cells.
Two-dimensional rotational spin-echo nuclear magnetic resonance in solids: correlation of chemical shift and dipolar interactions (1981)

Two-dimensional NMR techniques which sep. the chem. shift and heteronuclear dipolar interactions were applied to samples spinning at the magic angle. Because of the inhomogeneous nature of the 2 interactions, rotational echoes were obsd. in the time domain of each dimension. The corresponding Fourier transforms yield rotational sideband spectra which provide information on the principal values and relative orientations of the shift and dipolar tensors, and from the latter, internuclear distances may be calcd. The techniques therefore provide a means for obtaining structural data, for example, 13C-1H and 15N-1H distances, in powder samples. [on SciFinder (R)]
BT RSS as a bending indicator in a deformable mobile device (2014)

Bluetooth (BT) connectivity is today an essential feature in mobile devices complementing cellular connectivity. This paper discusses simulations of received signal strength (RSS) in a deformable product concept which includes two BT radiators and highlights opportunities and challenges to use RSS simulations during product concept phase.
Room Temperature Hydrosilylation of Silicon Nanocrystals with Bifunctional Terminal Alkenes (2013)

H-terminated Si nanocrystals undergo room temperature hydrosilylation with bifunctional alkenes with distal polar moieties-ethyl ester, methyl ester, or carboxylic acids-without the aid of light or added catalyst. The passivated Si nanocrystals exhibit bright photoluminescence (PL) and disperse in polar solvents, including water. We propose a reaction mechanism in which ester or carboxylic acid groups facilitate direct nucleophilic attack of the highly curved Si surface of the nanocrystals by the alkene.
esophageal Varices in Patients with cirrhosis: Usefulness of Three-dimensional MR Elastography with Echo-planar Imaging Technique 1 (2014)

This retrospective study received institutional review board approval, and informed consent was waived. One hundred thirty-nine patients with liver cirrhosis who underwent liver DCE MR imaging, including MR elastography, were included. Hepatic stiffness (HS) and spleen stiffness (SS) values assessed with MR elastography, as well as spleen length, were correlated with the presence of esophageal varices and high-risk varices by using Spearman correlation analysis. The diagnostic performance of MR elastography was compared with that of DCE MR imaging and combined assessment of MR elastography and DCE MR imaging by using receiver operating characteristic analysis. MR elastography reproducibility was assessed prospectively, with informed consent, in another 15 patients by using intraclass correlation coefficients.
1<sup>st</sup> International workshop on the engineering of mobile-enabled systems (MOBS 2013) (2013)

Mobile-enabled systems make use of mobile devices, RFID tags, sensor nodes, and other computing-enabled mobile devices to gather contextual data from users and the surrounding changing environment. Such systems produce computational data that can be stored and used in the field, shared between mobile and resident devices, and potentially uploaded to local servers or the cloud — a distributed, heterogeneous, context-aware, data production and consumption paradigm. Mobile-enabled systems have characteristics that make them different from traditional systems, such as limited resources, increased vulnerability, performance and reliability variability, and a finite energy source. There is significantly higher unpredictability in the execution environment of mobile apps. This workshop brings together experts from the software engineering and mobile computing communities — with notable participation from researchers and practitioners in the field of distributed systems, enterprise systems, cloud systems, ubiquitous computing, wireless sensor networks, and pervasive computing — to share results and open issues in the area of software engineering of mobile-enabled systems.
(Invited) Atomic Layer Etching Using Thermal Reactions: Atomic Layer Deposition in Reverse (2015)

Atomic layer etching (ALE) can remove thin films with atomic layer control based on sequential, self-limiting surface reactions. ALE can be viewed as atomic layer deposition (ALD) in reverse. This paper reviews Al 2 O 3 ALE using sequential, self-limiting thermal reactions. In the proposed mechanism for thermal Al 2 O 3 ALE, fluorination reagents, such as HF, fluorinate the Al 2 O 3 substrate to form an AlF 3 surface layer and volatile H 2 O. A metal precursor, such as Sn(acac) 2 , subsequently accepts fluorine from the AlF 3 surface layer and donates an acac ligand to the aluminum in the AlF 3 surface layer to form volatile Al(acac) 3 or AlF(acac) 2 reaction products. These fluorination and ligand-exchange reactions with HF and Sn(acac) 2 lead to temperature-dependent etching rates of Al 2 O 3 from 0.14 Å/cycle at 150°C to 0.61 Å/cycle at 250°C. This reaction mechanism can be extended to a variety of other materials including metal nitrides, metal phosphides, metal arsenides and elemental metals.
P‐127: Dual‐Gate Self‐Aligned IGZO TFTs Monolithically Integrated with High‐Temperature Bottom Moisture Barrier for Flexible AMOLED (2018)

We present a 350°C self‐aligned dual‐gate a‐IGZO backplane technology with a monolithically integrated multi‐layer high‐temperature thin‐film barrier for flexible AMOLED. Thin‐film barrier properties and TFT technology are optimized on 320 x 352mm substrates, and demonstrated in a flexible QQVGA 100 ppi AMOLED display prototype.
Towards a large-scale biologically realistic model of the hippocampus (2012)

Real neurobiological systems in the mammalian brain have a complicated and detailed structure, being composed of 1) large numbers of neurons with intricate, branching morphologies--complex morphology brings with it complex passive membrane properties; 2) active membrane properties--nonlinear sodium, potassium, calcium, etc. conductances; 3) non-uniform distributions throughout the dendritic and somal membrane surface of these non-linear conductances; 4) non-uniform and topographic connectivity between pre- and post-synaptic neurons; and 5) activity-dependent changes in synaptic function. One of the essential, and as yet unanswered questions in neuroscience is the role of these fundamental structural and functional features in determining "neural processing" properties of a given brain system. To help answer that question, we're creating a large-scale biologically realistic model of the intrinsic pathway of the hippocampus, which consists of the projection from layer II entorhinal cortex (EC) to dentate gyrus (DG), EC to CA3, DG to CA3, and CA3 to CA1. We describe the computational hardware and software tools the model runs on, and demonstrate its viability as a modeling platform with an EC-to-DG model.
Identification of IVGTT minimal glucose model by nonlinear mixed-effects approaches (2006)

Glucose minimal model parameters are commonly estimated by applying weighted nonlinear least squares to each individual subject's data. Sometimes, parameter precision is not satisfactory, especially in "data poor" conditions. In this work, the use of population analysis through nonlinear-mixed effects models is evaluated and its performance tested against the parameter estimates obtained by the standard individual approach through weighted nonlinear least squares. In particular, we compared the performance of two likelihood approximation methods to estimate nonlinear mixed-effects model parameters, i.e. the first-order conditional estimation (FOCE) and the Laplace approximation (Laplace) methods. The results show that nonlinear mixed-effects population modeling using the FOCE approximation can be successfully used in order to accurately estimate individual minimal model parameters
Conjugated microporous poly(phenylene butadiynylene)s (2007)

High surface area porous poly(phenylene butadiynylene) networks were obtained (BET surface area up to 842 m(2) g(-1)) by the palladium-catalyzed homocoupling of 1,3,5-triethynylbenzene and 1,4-diethynylbenzene.
Near-infrared mapping of ARP 299 (IC 694-NGC 3690) - Colliding galaxies unveiled (1985)

Near-infrared maps and multicolor photometry of the interacting galaxies IC 694 and NGC 3690 which form Arp 299 (= Markarian 171) are presented. These data reveal for the first time the distribution of nuclei and old red stars in a cataclysmically interacting system. The nuclei are considerably offset from the visual centroids of the galaxies but not from the mass centroids. The near-infrared colors of the most active regions are strongly affected by extinction, emission form hot dust, and bremsstrahlung. Near-infrared emission is also identified with secondary regions of star formation, probably resulting from the galaxies' interaction.
Monoisotopic Mass (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Evaluation and Binding‐Mode Prediction of Thiopyrone‐Based Inhibitors of Anthrax Lethal Factor (2006)

Lethal weapon: Heterocyclic chelators have been identified for use in anthrax lethal factor inhibitors (LFi). A complete LFi (AM-2S, shown), which consists of a thiopyrone chelator and a simple biphenyl backbone, has an IC50 value in the low micromolar range. Potential binding modes for AM-2S were computationally examined, and the importance of a molecular surface solvent–solute boundary in such studies was demonstrated. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2452/2006/z600102_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
SU‐E‐J‐72: Geant4 Simulations of Spot‐Scanned Proton Beam Treatment Plans (2014)

Purpose: To evaluate density inhomogeneities which can effect dose distributions for real‐time image gated spot‐scanning proton therapy (RGPT), a dose calculation system, using treatment planning system VQA (Hitachi Ltd., Tokyo) spot position data, was developed based on Geant4. Methods: A Geant4 application was developed to simulate spot‐scanned proton beams at Hokkaido University Hospital. A CT scan (0.98 × 0.98 × 1.25 mm) was performed for prostate cancer treatment with three or four inserted gold markers (diameter 1.5 mm, volume 1.77 mm3) in or near the target tumor. The CT data was read into VQA. A spot scanning plan was generated and exported to text files, specifying the beam energy and position of each spot. The text files were converted and read into our Geant4‐based software. The spot position was converted into steering magnet field strength (in Tesla) for our beam nozzle. Individual protons were tracked from the vacuum chamber, through the helium chamber, steering magnets, dose monitors, etc., in a straight, horizontal line. The patient CT data was converted into materials with variable density and placed in a parametrized volume at the isocenter. Gold fiducial markers were represented in the CT data by two adjacent voxels (volume 2.38 mm3). 600,000 proton histories were tracked for each target spot. As one beam contained about 1,000 spots, approximately 600 million histories were recorded for each beam on a blade server. Two plans were considered: two beam horizontal opposed (90 and 270 degree) and three beam (0, 90 and 270 degree). Results: We are able to convert spot scanning plans from VQA and simulate them with our Geant4‐based code. Our system can be used to evaluate the effect of dose reduction caused by gold markers used for RGPT. Conclusion: Our Geant4 application is able to calculate dose distributions for spot scanned proton therapy.
Genetic Control and Evolution of Sesquiterpene Biosynthesis in Lycopersicon esculentum and L. hirsutum (2000)

Segregation analysis between Lysopersicon esculentum (cultivated tomato) and L. hirsutum (wild form) in conjunction with positional verification by using near-isogenic lines demonstrated that biosynthesis of two structurally different classes of sesquiterpenes in these species is controlled by loci on two different chromosomes. A locus on chromosome 6, Sesquiterpene synthase1 (Sst1), was identified for which the L. esculentum allele is associated with the biosynthesis of beta-caryophyllene and alpha-humulene. At this same locus, the L. hirsutum allele is associated with biosynthesis of germacrene B, germacrene D, and an unidentified sesquiterpene. Genomic mapping, cDNA isolation, and heterologous expression of putative sesquiterpene synthases from both L. esculentum and L. hirsutum revealed that Sst1 is composed of two gene clusters 24 centimorgans apart, Sst1-A and Sst1-B, and that only the genes in the Sst1-A cluster are responsible for accumulation of chromosome 6-associated sesquiterpenes. At a second locus, Sst2, on chromosome 8, the L. hirsutum allele specified accumulation of alpha-santalene, alpha-bergamotene, and beta-bergamotene. Surprisingly, the L. esculentum allele for Sst2 is not associated with the expression of any sesquiterpenes, which suggests that cultivated tomato may have a nonfunctional allele. Sesquiterpene synthase cDNA clones on chromosome 6 do not cross-hybridize on genomic DNA gel blots with putative sesquiterpene synthases on chromosome 8, an indication that the genes in Sst1 and Sst2 are highly diverged, each being responsible for the biosynthesis of structurally different sets of sesquiterpenes.
Front Matter: Volume 7223 (2009)

This PDF file contains the front matter associated with SPIE Proceedings Volume 7223, including the Title Page, Copyright information, Table of Contents, Introduction, and the Conference Committee listing.
Handbook of Fractures. 2nd ed. (2002)

Kenneth J. Koval and Joseph D. Zuckerman. Philadelphia: Lippincott Williams and Wilkins; 2002. 426 pages. $49.95. 

This book provides the reader with a quick reference source for the evaluation and current treatment of fractures. It outlines epidemiology, anatomy, clinical evaluation, current classification schemes, recommended treatment, and complications that occur in association with common fractures. The review covers a wide range of injuries, including spinal fractures, upper and lower extremity fractures, and pediatric fractures.

The book …
Electron Injection into Plasma Waves at Sharp Density Transitions (2010)

We present a novel method of controlled electron injection from the background plasma into a laser driven plasma wave using a μm-scale density transition. Substantial quality improvements on the monoenergetic electron beam are demonstrated. © 2010 OSA/FiO/LS 2010.
Ion beam irradiation of Langmuir–Blodgett polydiacetylene films (1986)

Effects of ion beam irradiation of ≂100-nm-thick Langmuir–Blodgett polydiacetylene films have been investigated in the low-energy regime E&amp;lt;200 keV. Optical absorption and electrical resistivity measurements have been performed to characterize the modified materials. The results show that changes in optical and electrical properties associated with structural modifications are strongly correlated.
Hybrid Method of Transurethral Resection of Ejaculatory Ducts Using Holmium:Yttriumaluminium Garnet Laser on Complete Ejaculatory Duct Obstruction (2013)

A 32-year old single man presented with azoospermia and low semen volume which was noted one and half a year ago. Transrectal ultrasonography and seminal vesiculography were performed to evaluate ejaculatory duct obstruction, and transurethral resection of the ejaculatory duct was performed using a hybrid technique of holmium:yttriumaluminium garnet laser with monopolar transurethral resection to overcome the narrow prostatic urethra. To our knowledge, this is the first report on the successful outcome of a hybrid technique applied for transurethral resection of the ejaculatory duct.
Dissecting the Effects of Spinal Fusion and Deformity Magnitude on Quality of Life in Patients With Adolescent Idiopathic Scoliosis (2009)

Spinal fusion has an isolated negative effect on AIS patients' quality of life (Total score) mostly due to a decrease in scores of the Activity domain. The overall positive effect of surgery depends on the individual effects of spinal fusion (slight reduction in quality of life) and deformity reduction (modest improvement in quality of life).
A Study on the Operation Algorithm of Multi-Stave Using Leg Minimized Inverter (2023)

The method of using sound signals for underwater detection is called SONAR (Sound Navigation and Ranging) and consists of a sound source called SONAR Stave, a matching transformer, H-bridge inverter, LC filter, and battery. In addition, recently, studies using multiple SONAR Staves have been conducted to increase the detection distance and expand the detection direction. However, the use of multiple SONAR staves causes an increase in power consumption, which in turn increases the volume of inverters and filters. Therefore, recent research has conducted to reduce the volume of parts that consist of the SONAR system in order to solve this problem. However, there is currently no research conducted on suitable operating algorithms for power converters with reduced volume. Therefore, in this study, we propose an algorithm for the configuration of leg minimized inverter, which can generate the same output as the conventional setup. Also we experimentally verified this proposed algorithm.
KINEMATICS OF POSTERIOR CRUCIATE LIGAMENT (PCL) AND POSTEROLATERAL CORNER (PLC) DEFICIENT HUMAN CADAVER KNEE RECONSTRUCTED WITH SINGLE OR DOUBLE BUNDLE POSTERIOR CRUCIATE LIGAMENT (2008)

Aim: To analyse the posterior and external rotational laxities in single bundle PCL (sPCL) and double bundle PCL reconstruction (dPCL) in a PCL and PLC deficient knee. Methods: Ten fresh frozen were used. A custom made wooden rig with electromagnetic tracking was used to measured knee kinematics. Each knee was tested with posterior and anterior drawer forces of 80N and an external rotation moment of 5Nm when intact, after PCL resection, after dividing the PLC and after performing dPCL and sPCL reconstructions with a bone patellar tendon bone allograft and tibial inlay technique. Results: The one-tailed paired Student’s t test with Bon-ferroni correction was used. There was a significant difference between the ability of the dPCL and sPCL reconstruction to correct the posterior drawer in extension (p=0.002). There was no difference between the dPCL reconstruction and the intact condition of the knee near extension (p=0.142, Fig 1). There was no significant difference between the intact condition and both sPCL (p=0.26) and dPCL (p=0.20) reconstructions in flexion in restoring posterior laxity. Neither of the reconstructions could restore the rotational laxity (Fig 3). Conclusion: In a combined PCL and PLC deficient knee the posterior laxity can be controlled by both the sPCL as well as the dPCL reconstructions except near extension where the dPCL reconstruction was better.
Differentiation of tumour-stage mycosis fungoides, psoriasis vulgaris and normal controls in a pilot study using serum proteomic analysis (2007)

Serum proteomics should be further investigated for its potential to identify patients with neoplastic skin disease and its ability to determine disease prognosis.
Immuno‐epigenomic analysis identifies attenuated interferon responses in naïve CD4 T cells of adolescents with peanut and multi‐food allergy (2022)

We find that attenuated nCD4T cell responses from adolescents with food allergy are associated with specific epigenetic variation, including disruption of interferon responses, indicating dysregulation of key immune pathways that may contribute to a persistent FA phenotype. However, we recognize the small sample size, and the consequent restraint on reporting adjusted p-value statistics as limitations of the study. Further study is required to validate these findings.