gebhart/patrepeval huggingface dataset:
DIRECT MEASUREMENTS OF ANCHOR DAMPING IN PRESSURE-LIMITED RING RESONATORS (2018)

We measure the quality factor (Q) due to gas damping, thermoelastic dissipation (TED), and anchor damping of a ring resonator operating in the wineglass mode. We analyze the Q over a range of temperatures and pressures and compare anchor damping of two different anchor designs. This method provides a path towards better understanding of anchor damping in MEMS.
A precise timing mechanism may underlie a common speech perception and production area in the peri-Sylvian cortex of the dominant hemisphere (1983)

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PEMFC Component Characterization and Its Relationship to Mass-Transport Overpotentials during Long-Term Testing (2006)

Individual overpotential contributions to PEM Fuel Cell performance are examined to determine how these change during long operating times. The cathode mass-transport overpotential and its relationship to O2 diffusion mechanisms and liquid- water transport is examined in detail. A method, governing equation, and durability case study is presented here for estimating both overpotential contributions as a function of testing time, as well as the breakdown of mass-transport overpotential for the cathode Gas Diffusion Layer (GDL) and catalyst layer. The importance of correlating component characterization with this durability data is also shown using high-resolution scanning electron microscopy (HRSEM) and pore- size distribution (PSD) measurements obtained with Hg and H2O porosimetry.
Abstract 2803: The role of the sarcosine pathway in prostate cancer progression (2011)

Abstract Differential metabolomic alterations occur during prostate cancer progression. Exploring the metabolome of prostate cancer progression, may lead to the identification of critical biomarkers for cancer invasion and disease aggressiveness. Recently, we have identified sarcosine, an N-methyl derivative of the amino acid glycine, as a key metabolite increased most robustly in metastatic prostate cancer and detectable in the urine of men with organ-confined disease (Sreekumar et al., Nature, 2009). Here, we examined if the proximal regulatory enzymes of sarcosine, glycine-N-methyl transferase (GNMT), sarcosine dehydrogenase (SARDH) and pipecolic acid oxidase (PIPOX), play a functional role in prostate cancer progression. By tissue microarray analysis, we observed that GNMT protein levels are strongly associated with prostate cancer aggressiveness. Here, we demonstrate that stable knockdown of GNMT inhibits cell proliferation, induces apoptosis, attenuates cell invasion in Matrigel coated transwells, and blocks the anchorage-independent growth of the cancerous DU145 cells. Overexpression of GNMT in benign RWPE cells showed significantly increased cell invasion and increased sarcosine level. Importantly, knockdown of GNMT in DU145 cells also inhibited intravasation using chick chorioallantoic membrane (CAM) assay and tumor growth in xenograft assays. In contrast, we also showed that while the knockdown of sarcosine degrading enzymes, SARDH and PIPOX, induced invasion and increased sarcosine level in RWPE cells, the overexpression of these enzymes attenuated invasion and decreased sarcosine level. Further, overexpression of SARDH inhibited cell proliferation, blocked the anchorage-independent growth and also inhibited intravasation using CAM assay. Taken together, this study shows that the components of the sarcosine pathway may have potential as biomarkers of prostate cancer progression and serve as new avenues for therapeutic intervention. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2803. doi:10.1158/1538-7445.AM2011-2803
Urolithiasis, Endourology and Laparoscopy (2008)

No AccessJournal of UrologyAdult urology1 Mar 2008Urolithiasis, Endourology and Laparoscopy Ralph ClaymanM.D. Ralph ClaymanRalph Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2007.11.016AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Urolithiasis, Endourology and Laparoscopy." The Journal of Urology, 179(3), p. 985 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 3March 2008Page: 985 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Ralph Clayman More articles by this author Expand All Advertisement Loading ...
Supplementary Figures 6 & 7 from A Phase II, Randomized, Open-Label Study of Neoadjuvant Degarelix versus LHRH Agonist in Prostate Cancer Patients Prior to Radical Prostatectomy (2023)

&lt;p&gt;Supplementary Figure 6. Comparison of intratumoral dihydrotestosterone (DHT) levels after treatment with degarelix, degarelix and bicalutamide, or LHRH agonist and bicalutamide. (ONLINE ONLY) Supplementary Figure 7. Comparison of intratumoral testosterone levels after treatment with degarelix, degarelix and bicalutamide, or LHRH agonist and bicalutamide. (ONLINE ONLY)&lt;/p&gt;
Evaluation of Soybean Genotypes for Resistance to Charcoal Rot (2011)

Charcoal rot, caused by Macrophomina phaseolina, significantly reduces yield in soybean more than most other diseases in the midsouthern United States. There are no commercial genotypes marketed as resistant to charcoal rot. Reactions of 27 maturity group (MG) III, 29 Early MG IV, 34 Late MG IV, and 59 MG V genotypes were evaluated for M. phaseolina between 2006 and 2008 in a non-irrigated, no-till field that had been artificially infested for three years. There was significant variation in root colonization among genotypes and years, indicating the value of screening genotypes over multiple years. Based on CFUI there was no genotype that was consistently immune to charcoal rot each year. However, there were a total of six genotypes (one genotype in MG III, one in Late MG IV, and four in MG V) that were identified as moderately resistant. Some of the commercial and public genotypes were resistant to M. phaseolina at levels equal to or greater than the standard DT97-4290, a moderately resistant cultivar. The genotypes identified as having moderate resistance across the three years could be useful as sources for developing resistant soybean genotypes. Accepted for publication 27 July 2011. Published 26 September 2011.
A viscous bioerodible poly(ortho ester) as a new biomaterial for intraocular application (2000)

The biocompatibility of a viscous, hydrophobic, bioerodible poly(ortho ester) (POE) intended for intraocular application was investigated. POE was evaluated as a blank carrier and as containing modulators of degradation. Each formulation was injected intracamerally and intravitreally in rabbit eyes, and clinical and histological examinations were performed postoperatively for 2 weeks. In the case of intracameral injections, polymer biocompatibility appeared to depend on the amount injected in the anterior chamber. When 50 microL was administered, the polymer degraded within 2 weeks, and clinical observations showed good biocompatibility of POE with no toxicity to the ocular tissues or increase in intraocular pressure. The injection of a larger volume, 100 microL, of POE, appeared inappropriate because of direct contact of polymeric material with the corneal endothelium, and triggered reversible edema and inflammation in the anterior chamber of the eye that regressed after a few days. After intravitreal administration, POE was well tolerated and no inflammatory reaction developed during the observation period. The polymer degraded slowly, appearing as a round whitish bubble in the vitreous cavity. The presence of modulators of degradation both improved POE biocompatibility and prolonged polymer lifetime in the eye. POE appears to be a promising biomaterial for clinical intraocular application.
Hsp90 associates with N‐terminal extended peptides and is required for direct antigen presentation (2008)

Antigen presentation by MHC I molecules requires the generation of peptides in the cytosol, ferrying of peptides from cytosol to endoplasmic reticulum, loading of MHC I with peptides, and transport of MHC I‐peptide complexes to the cell surface. Hsp90 is a cytosolic chaperone known to associate with peptide and peptide precursors of MHC I epitopes. We report here that treatment of a variety of cells with hsp90 inhibitors leads to generation of “empty” MHC I molecules on the cell surface, due to inhibited loading of MHC I with peptides. Inhibition of hsp90 does not inhibit protein synthesis in general, nor synthesis of MHC I in particular, nor does it affect the activity of proteasomes. Hsp90‐inhibited cells, like lactacystin‐treated cells, are poor stimulators of T lymphocytes. The role of hsp90 in presentation of an ovalbumin epitope is shown to be at a post‐proteasomal step: hsp90 associates with N‐terminally extended precursors of the SIINFEKL epitope, and such peptides are depleted from hsp90 preparations in inhibitor‐treated cells. These results argue for a substantial role for hsp90 in chaperoning of antigenic peptides in direct presentation. This work was supported by NIH grant CA 084479 to P.K.S.
Transport Mechanisms Underlying Ionic Conductivity in Nanoparticle-Based Single-Ion Electrolytes (2020)

Recent studies have demonstrated the potential of nanoparticle-based single-ion conductors as battery electrolytes. In this work, we introduce a coarse-grained multiscale simulation approach to identify the mechanisms underlying the ion mobilities in such systems and to clarify the influence of key design parameters on conductivity. Our results suggest that for the experimentally studied electrolyte systems, the dominant pathway for cation transport is along the surface of nanoparticles, in the vicinity of nanoparticle-tethered anions. At low nanoparticle concentrations, connectivity of cationic surface transport pathways and conductivity increase with nanoparticle loading. However, cation mobilities are reduced when nanoparticles are in close vicinity, causing conductivity to decrease for suffciently high particle loadings. We discuss the impacts of cation and anion choice as well as solvent polarity within this picture and suggest means to enhance ionic conductivities in single-ion conducting electrolytes based on nanoparticle salts.
Abdominal Radical Trachelectomy as a Fertility-Sparing Procedure in Women With Early Stage Cervical Cancer in a Series of 61 Women (2009)

Although vaginal radical trachelectomy is an effective treatment for early stage cervical cancer and has an acceptable live birth rate, there are concerns over its oncological safety and possible surgical injury with this radical procedure. Moreover, most gynecologists have difficulty performing this unfamiliar procedure and require special training. Many of these problems can be overcome with the use of abdominal radical trachelectomy. The abdominal approach provides adequate resection of the parametrial and vaginal tissue and does not require special training. Only a few case studies have investigated abdominal radical trachelectomy. This retrospective study presents follow-up data and reviews a series of cases conducted in Japanese women with early stage cervical cancer who had undergone elective abdominal radical trachelectomy and pelvic lymphadenectomy between 2002 and 2008. The aim of the study was to assess the effectiveness and safety of the abdominal approach in this population. A total of 61 patients at a median age of 33 years (range, 26–44 years) were followed up for a median 27 months (range, 1–67 months). There were 6 recurrences (9.8%, 6/61); 1 occurred in a patient with adenocarcinoma. None of the other 5 recurrences were found in cases with a primary tumor diameter of <20 mm. Twenty-nine (47.5%) of the 61 patients attempted to conceive and 4 (13.8%) were successful. Of the 4 live births, 2 were preterm, the remaining 2 were full term. The rates of serious intraoperative and postoperative complications were similar to those reported in the literature for standard radical hysterectomy and lymphadenectomy. The investigators conclude from these findings that an abdominal radical trachelectomy is an effective and relatively safe procedure in selected patients and may be an acceptable treatment option for young women with early stage cervical cancer.
<title>Evaluation of beam-path configurations for use with a monostatic OP-FTIR capable of rapid beam movement for tomographic reconstruction of gas and vapor concentrations in workplaces</title> (1995)

Beam path average data from an open path Fourier transform infrared (OP-FTIR) spectrometer can be used to reconstruct 2D concentration maps of the gas and vapor contaminants in workplaces using computed tomographic (CT) techniques. However, a practical limitation arises because many source and detector units are required to produce a sufficient number of intersecting beam paths in order to reconstruct concentration maps. A monostatic OP-FTIR system which is capable of rapid beam movement can be used to eliminate this deficiency. Instead of many source and detector units, a number of the intersecting folded beam paths can be obtained using many flat mirrors and retro-reflectors. We conducted tests of several beam configurations generated for a single scanning FTIR system using 54 flat mirrors and 56 retro-reflectors mounted along the perimeter walls of a typical sized 24 foot by 21 foot test room. The virtual source CT configurations were tested using concentration maps created from tracer gas concentration distributions measured experimentally in a test chamber. Computer simulations of different beam configurations were used to determine the optimal beam geometry. We found that high concentration areas and the general concentration gradient pattern could be resolved from tomographic reconstructions calculated based on 102 folded beam paths. However, the reconstructions showed some effects from noise and peak-smearing artifacts. The noise level could be reduced and the quality of reconstruction maps were improved by using a spline interpolation method to correct for the influence of folded rays. We refer to this approach as a virtual source CT geometry.
A 180 My-old female-specific genome region in sturgeon reveals the oldest known vertebrate sex determining system with undifferentiated sex chromosomes (2020)

Summary Several hypotheses explain the prevalence of undifferentiated sex chromosomes in poikilothermic vertebrates. Turnovers change the master sex determination gene, the sex chromosome or the sex determination system (e.g. XY to WZ). Jumping master genes stay main triggers but translocate to other chromosomes. Occasional recombination (e.g. in sex-reversed females) prevents sex chromosome degeneration. Recent research has uncovered conserved heteromorphic or even homomorphic sex chromosomes in several clades of non-avian and non-mammalian vertebrates. Sex determination in sturgeons (Acipenseridae) has been a long-standing basic biological question, linked to economical demands by the caviar-producing aquaculture. Here, we report the discovery of a sex-specific sequence from sterlet ( Acipenser ruthenus ). Using chromosome-scale assemblies and pool-sequencing, we first identified a ~16 kb female-specific region. We developed a PCR-genotyping test, yielding female-specific products in six species, spanning the entire phylogeny with the most divergent extant lineages ( A. sturio, A. oxyrinchus vs. A. ruthenus, Huso huso ), stemming from an ancient tetraploidization. Similar results were obtained in two octoploid species ( A. gueldenstaedtii, A. baerii ). Conservation of a female-specific sequence for a long period, representing 180 My of sturgeon evolution, and across at least one polyploidization event, raises many interesting biological questions. We discuss a conserved undifferentiated sex chromosome system with a ZZ/ZW-mode of sex determination and potential alternatives.
Predicting the Rate of Homogeneous Intermetallic Nucleation within Steep Composition Gradients (2020)

Simulations of isothermal homogeneous nucleation from deeply undercooled amorphous melts exhibit systematic variations in nucleation behavior depending upon the strength of an imposed composition gradient. Data from molecular dynamics (MD) simulations in a model Ni/Al system permit quantification of the nucleation rate of the NiAl-B2 intermetallic phase and indicate that nucleation proceeds in a polymorphous mode. The nucleation rate decreases with increasing gradient, and nucleation is completely suppressed above a critical gradient. Based on an argument of crystal nucleus stability, a simple estimate provides good prediction of the critical gradient. A modified classical nucleation model parameterized with thermodynamic and kinetic quantities calculated independently predicts the nucleation rates and their variation with the imposed gradient, matching the MD results very well.
Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia (2015)

Trefoil factor 3 (TFF3), also called intestinal trefoil factor or Itf, is a 59 amino acid peptide found as a homodimer predominantly along the gastrointestinal tract and in serum. TFF3 expression is elevated during gastrointestinal adenoma progression and has been shown to promote mucosal wound healing. Here we show that in contrast to other trefoil factor family members, TFF1 and TFF2, TFF3 is highly expressed in mouse duodenum, jejunum and ileum and that its expression is regulated by food intake. Overexpression of TFF3 using a recombinant adeno-associated virus (AAV) vector, or daily administration of recombinant TFF3 protein in vivo improved glucose tolerance in a diet-induced obesity mouse model. Body weight, fasting insulin, triglyceride, cholesterol and leptin levels were not affected by TFF3 treatment. Induction of mucinous metaplasia was observed in mice with AAV-mediated TFF3 overexpression, however, no such adverse histological effect was seen after the administration of recombinant TFF3 protein. Altogether these results suggest that the therapeutic potential of targeting TFF3 to treat T2D may be limited.
Electronic laser phase noise reduction (2013)

The first integrated wideband laser phase noise reduction scheme is presented where the laser phase noise is first detected using a photonic chip, processed using an electronic chip, and subtracted from the laser phase in a feed-forward manner. The proof-of-concept experiments on a commercially available 1553nm distributed feedback laser show linewidth reduction from 6MHz to 250kHz equivalent to 14dB phase noise improvement. The hybrid integration of the photonic and electronic chips enables dramatic power consumption and area reduction compared to bench-top designs. This feed-forward scheme performs wideband phase noise reduction independent of the light source and, as such, it is compatible with several types of lasers.
Characterization of Optical Sensors for Real-Time Measurement of Motorcycle Tilt Angles (2008)

An effective optical sensor for real-time measurement of the tilt angle in high-speed motorcycles was developed and tested. The basic idea and target of this work is to create a compact, reliable and also low-cost optical triangulators capable of accurate in-field measurements, in the harsh environment of sport motorcycles. Calculations of the required system sensitivity and allowable accuracy are described for this kind of optical sensor. The first prototypes, based on LED emitters, demonstrate the viability of such optical solution but they suffer from significant performance degradation due to solar interference, moved at high Fourier frequency by the combined effect asphalt roughness and motorbike speed. A second-generation instrumentation is under study, relying on laser emitters. Such novel triangulators promise good and reliable performance for the proposed application, keeping low costs and encumbrance and overcoming the problem of solar interference.
Inhibition of Galactosyltransferases by a Novel Class of Donor Analogues (2012)

Galactosyltransferases (GalT) are important molecular targets in a range of therapeutic areas, including infection, inflammation, and cancer. GalT inhibitors are therefore sought after as potential lead compounds for drug discovery. We have recently discovered a new class of GalT inhibitors with a novel mode of action. In this publication, we describe a series of analogues which provide insights, for the first time, into SAR for this new mode of GalT inhibition. We also report that a new C-glycoside, designed as a chemically stable analogue of the most potent inhibitor in this series, retains inhibitory activity against a panel of GalTs. Initial results from cellular studies suggest that despite their polarity, these sugar-nucleotides are taken up by HL-60 cells. Results from molecular modeling studies with a representative bacterial GalT provide a rationale for the differences in bioactivity observed in this series. These findings may provide a blueprint for the rational development of new GalT inhibitors with improved potency.
Diphosphines with natural bite angles near 120.degree. increase selectivity for n-aldehyde formation in rhodium-catalyzed hydroformylation. [Erratum to document cited in CA117(3):25899x] (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiphosphines with natural bite angles near 120.degree. increase selectivity for n-aldehyde formation in rhodium-catalyzed hydroformylation. [Erratum to document cited in CA117(3):25899x]Charles P. Casey, Gregory T. Whiteker, Margaret G. Melville, Lori M. Petrovich, James A. Gavney Jr., and Douglas R. PowellCite this: J. Am. Chem. Soc. 1992, 114, 26, 10680Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/ja00052a099https://doi.org/10.1021/ja00052a099research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts