gebhart/patrepeval huggingface dataset:
5G in space: PHY-layer design for satellite communications using non-orthogonal multi-carrier transmission (2014)

For the 5th generation of terrestrial mobile communications, Multi-Carrier (MC) transmission based on non-orthogonal waveforms is a promising technology component compared to orthogonal frequency division multiplex (OFDM) in order to achieve higher throughput and enable flexible spectrum management. Coverage extension and service continuity can be provided considering satellites as additional components in future networks by allowing vertical handover to terrestrial radio interfaces. In this paper, the properties of Filter Bank Multicarrier (FBMC) as potential MC transmission scheme is discussed taking into account the requirements for the satellite-specific PHY-Layer like non-linear distortions due to High Power Amplifiers (HPAs). The performance for specific FBMC configurations is analyzed in terms of peak-to-average power ratio (PAPR), computational complexity, non-linear distortions as well as carrier frequency offsets sensitivity (CFOs). Even though FBMC and OFDM have similar PAPR and suffer comparable spectral regrowth at the output of the non linear amplifier, simulations on link level show that FBMC still outperforms OFDM in terms of CFO sensitivity and symbol error rate in the presence of non-linear distortions.
Exact averaging of laminar dispersion (2011)

We use the Liapunov–Schmidt (LS) technique of bifurcation theory to derive a low-dimensional model for laminar dispersion of a nonreactive solute in a tube. The LS formalism leads to an exact averaged model, consisting of the governing equation for the cross-section averaged concentration, along with the initial and inlet conditions, to all orders in the transverse diffusion time. We use the averaged model to analyze the temporal evolution of the spatial moments of the solute and show that they do not have the centroid displacement or variance deficit predicted by the coarse-grained models derived by other methods. We also present a detailed analysis of the first three spatial moments for short and long times as a function of the radial Peclet number and identify three clearly defined time intervals for the evolution of the solute concentration profile. By examining the skewness in some detail, we show that the skewness increases initially, attains a maximum for time scales of the order of transverse diffusion time, and the solute concentration profile never attains the Gaussian shape at any finite time. Finally, we reason that there is a fundamental physical inconsistency in representing laminar (Taylor) dispersion phenomena using truncated averaged models in terms of a single cross-section averaged concentration and its large scale gradient. Our approach evaluates the dispersion flux using a local gradient between the dominant diffusive and convective modes. We present and analyze a truncated regularized hyperbolic model in terms of the cup-mixing concentration for the classical Taylor–Aris dispersion that has a larger domain of validity compared to the traditional parabolic model. By analyzing the temporal moments, we show that the hyperbolic model has no physical inconsistencies that are associated with the parabolic model and can describe the dispersion process to first order accuracy in the transverse diffusion time.
Biological and medical applications of photoacoustic and photothermal phenomena (1999)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation T. N. Mills; Biological and medical applications of photoacoustic and photothermal phenomena. AIP Conference Proceedings 15 March 1999; 463 (1): 563–566. https://doi.org/10.1063/1.58134 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation (2014)

Our data support an updated model of sepsis pathogenesis in which endotoxin tolerance-mediated immune dysfunction (cellular reprogramming) is present throughout the clinical course of disease and related to disease severity. Thus endotoxin tolerance might offer new insights guiding the development of new therapies and diagnostics for early sepsis.
Stress mitigation of 3D-stacking/packaging induced stresses (2018)

Where the introduction of 3D stacked ICs offers opportunities for new and faster applications, the use of ultra-thin stacked Si dies leads to new reliability challenges. One such challenge is to cope with the thermo-mechanical stresses induced by mismatches in the Coefficient of Thermal Expansion between the different materials used for stacking and packaging such as Si, copper, overmoulds, laminates and underfills, amongst others. These stresses are a key-concern for today's 2D-technologies and are even more severe for 2.5/3D-stacking and -packaging technologies with high interconnect densities.
<title>Experiments with new phase image encrypting method</title> (1999)

Recently, there has been considerable interest in the application of combined phase/amplitude encryption to the field of optical pattern recognition based security systems, due to the high level of security that it offers1. We have developed a new phase-only encryption technique based in principle on a phase-coding method which uses a generalization of the Zernike phase contrast technique, but breaks the small-phase-angle limitation of Zernike's method2. This phase-coding technique for image formation, in which the spatial average value of an input phase modulated image is combined with a pre-estimated phase retardation produced by a phase contrast filter, has been demonstrated experimentally3. In this paper we describe an extension of our phase-coding method4 and its application in an experimental system for the decryption and visualization of phase encrypted images using commercially available Parallel-Aligned Liquid Crystal Spatial Light Modulators (PAL-SLM) supplied by Hamamatsu Photonics5.
Three-dimensional photoacoustic imaging of subcutaneous microvasculature in vivo (2006)

Three-dimensional photoacoustic imaging of subcutaneous microvasculature in small animals is realized <i>in vivo</i> using photoacoustic microscopy. Previously, degraded lateral resolution in the out-of-focus region made three-dimensional visualization impractical. With the help of a virtual-detector synthetic aperture focusing technique, depth-independent lateral resolution is achieved. Therefore, volumetric imaging of the vessels is realized with a lateral resolution of 45 &#956;m and an axial resolution of 15 &#956;m. Detailed structural information, such as vessel depth and spatial orientation, are revealed with new clarity.
Experimental Allergic Encephalitis; Treatment with Drugs Which Alter CNS Serotonin Levels (1982)

Lennon and Carnegie have proposed that the clinical symptomatology of experimental allergic encephalitis (EAE), an acute autoimmune demyelinating disease, may be due, at least in part, to an immune response directed against CNS serotonin receptors. To test this hypothesis we treated strain 13 guinea pigs, which had been immunized with guinea pig basic protein (GPBP) in complete Freund's adjuvant (CFA), with drugs known to affect central nervous system (CNS) serotonin levels. These drugs included imipramine hydrochloride, tryptophan and carbidopa which increase CNS serotonin and reserpine which decreases it. Five experiments were conducted in which all immunized animals treated with saline only died, as expected, as did all animals treated with reserpine which died even more quickly. A significant proportion of animals treated with the other three drugs, alone or in combination, survived or lived longer than controls. We conclude that survival of animals with EAE is enhanced by treatment with these drugs. We suggest that further evaluation of a possible blockade in serotonin transmission in EAE and multiple sclerosis (MS) is warrented, since, if such a blockade were demonstrated, it is possible that these drugs may have potential for therapeutic efficacy in patients with MS.
Low Frequency of Cytotoxic T Lymphocytes against the Novel HLA-A*0201-Restricted JC Virus Epitope VP1p36in Patients with Proven or Possible Progressive Multifocal Leukoencephalopathy (2003)

JC virus (JCV)-specific cytotoxic T lymphocytes (CTL) in peripheral blood are associated with a favorable outcome in patients with progressive multifocal leukoencephalopathy (PML). However, the frequency of these cells in the peripheral blood mononuclear cells (PBMC) of PML patients is unknown. To develop a highly sensitive assay for detecting the cellular immune response against this virus, we performed a CTL epitope mapping study of JCV VP1 major capsid protein by using overlapping peptides. A novel HLA-A*0201-restricted epitope, the VP1(p36) peptide SITEVECFL, was characterized. The cellular immune response against JCV was assessed in 32 study subjects. By combining the results of the (51)Cr release assay on pooled peptides and staining with the HLA-A*0201/JCV VP1(p36) tetramer, VP1-specific CTL were detected in 10 of 11 PML survivors (91%) versus only 1 of 11 PML progressors (9%, P = 0.0003). VP1-specific CTL were also detected in two of two patients recently diagnosed with PML and in four of four human immunodeficiency virus-positive patients with possible PML. The frequency of CTL specific for the novel VP1(p36) and the previously described VP1(p100) epitopes was determined. In two patients, the frequency of CTL specific for the VP1(p36) or VP1(p100) epitopes, as determined by fresh blood tetramer staining (FBTS), ranged from 1/6,000 to 1/24,000 PBMC. A CTL sorting technique combining tetramer staining and selection with immunomagnetic beads allowed the detection of epitope-specific CTL in two cases that were determined to be negative by FBTS. The phenotype of these CTL in vivo was consistent with activated memory cells. These data suggest that, although present in low numbers, JCV-specific CTL may be of central importance in the containment of JCV spread in immunosuppressed individuals.
1519: EFFECT OF POSITIVE END-EXPIRATORY PRESSURE ON CARDIAC OUTPUT AND PO2 DURING CPR (2019)

Levenbrown, Yosef1; Keith, James2; Burr, Katlyn2; Hesek, Anne2; Shaffer, Thomas2 Author Information
Investigation of the boundary conditions for oblique testin of motorcycle helmets using numerical methods : with focus on the human neck and shoulder (2011)

Investigation of the boundary conditions for oblique testin of motorcycle helmets using numerical methods : with focus on the human neck and shoulder
Meningococcal Endocarditis Presenting as Cellulitis (1995)

We report the case of a patient with mixed connective tissue disease who presented with two very unusual manifestations of meningococcal disease, cellulitis and endocarditis, concurrently. We also review the literature concerning Neisseria meningitidis as a causative agent of cellulitis or endocarditis. While meningococcal endocarditis or cellulitis is very rare, autoimmune disease predisposes patients to meningococcal infection. Therefore, unusual infections with this organism should be considered in the differential diagnosis of fever and rash in patients with connective tissue diseases.
The EZ Trainer: Validation of a Portable and Inexpensive Simulator for Training Basic Laparoscopic Skills (2007)

The EZ trainer system has face and content validity as a portable laparoscopic trainer across a broad range of surgical disciplines.
Abstract OR-16: High Resolution Cryo-Electron Microscopy and New Direct Electron Detector from Gatan - K3 (2019)

Background: Much of the success of modern cryo-Electron microscopy is the result of advances in electron detector, specifically the advent of direct electron detectors [Kuhlbrandt, 2014, Biochemistry]. Of particular utility has been the Gatan K2 camera that was the first camera to provide single electron detection at practical dose rates, resulting in dramatic improvements in DQE and reduction in noise. The K2 also introduced the concept of super-resolution where the electrons can be registered to sub-pixel resolution. Despite the very high internal readout rate of the K2 camera (400 frames/sec), electron coincidence loss reduces DQE at doses above 3-5 e-/pixel/second, requiring prolonged exposures [Li, 2013, J Struct Biol]. The high frame rate does not only increase the DQE, but also allows to correct for beam-induced sample motion by making an alignment of the individual frames before averaging [Li, 2013, Nat Methods], [Zheng, 2017, Nat Methods].
Low-loss, low-voltage, AlGaAs/GaAs high speed optical switch with doping and composition graded heterojunction interfaces (2007)

Carrier-injection-type high-speed semiconductor optical switches have been of interest in recent years due to their nanosecond switching times, their immunity to variations in temperature, wavelength, polarization, etc, and the ease with which they can be monolithically integrated with other optoelectronic components and electronic circuitry. Their drawbacks, however, have been high insertion loss and excessive power dissipation. To overcome these limits, a novel, large cross-section, single-mode AlGaAs/GaAs optical switch has been designed and fabricated. The switch's strip-loaded waveguide uses a five-layer W-shaped heterostructure and a 1.7&mgr;m-thick core layer, which provides high fiber-coupling efficiency. Since the constituent heterojunction band discontinuities can impede the current across the junction, the addition of 20nm-40nm thick, compositionally graded interfaces significantly reduces the switching voltage. In addition, using a lightly doped core layer can reduce the series resistance of the switch, which is important in heat reduction. The core doping needs to be low otherwise it will cause increased free-carrier absorption, which contributes to high insertion loss. We have fabricated switches with different core doping levels using both abrupt and graded heterojunctions. The measured on-chip optical propagation losses are 0.3dB/cm for unintentionally doped core, 1.5dB/cm for n = 1x10<sup>16</sup>cm<sup>-3</sup> doped core, and 2.7dB/cm for n = 5x10<sup>16</sup>cm<sup>-3</sup> doped core. The measured I-V curves show that the switching voltage can be reduced by changing abrupt heterojunctions to graded ones. The calculated theoretical band structure for switches with abrupt/graded heterojunctions based on thermionic emission clearly demonstrated the advantages of applying grading in semiconductor optical switches.
Improving the performance of motor-impaired users with automatically-generated, ability-based interfaces (2008)

We evaluate two systems for automatically generating personalized interfaces adapted to the individual motor capabilities of users with motor impairments. The first system, SUPPLE, adapts to users' capabilities indirectly by first using the ARNAULD preference elicitation engine to model a user's preferences regarding how he or she likes the interfaces to be created. The second system, SUPPLE++, models a user's motor abilities directly from a set of one-time motor performance tests. In a study comparing these approaches to baseline interfaces, participants with motor impairments were 26.4% faster using ability-based user interfaces generated by SUPPLE++. They also made 73% fewer errors, strongly preferred those interfaces to the manufacturers' defaults, and found them more efficient, easier to use, and much less physically tiring. These findings indicate that rather than requiring some users with motor impairments to adapt themselves to software using separate assistive technologies, software can now adapt itself to the capabilities of its users.
Strength aspects for the design of ZERODUR glass ceramics structures (2007)

In some applications mirrors and support structures from the zero expansion glass ceramic material ZERODUR<sup>(R)</sup> have to endure mechanical loads, e.g. rocket launches or controlled deformations for optical image correction. Like for other glassy materials the strength of glass ceramics is dominated by its surface condition. Similar to other glass ceramics ZERODUR<sup>(R)</sup> has higher strengths than glasses for comparable surface conditions. For the design of ZERODUR<sup>(R)</sup> parts well known rules of thumb for its strength are not sufficient in any case. So new information and data with enlarged sample sets and hence better statistics have been collected to improve the understanding of its behavior under mechanical loads. Finally an outlook is given on the application of ZERODUR<sup>(R)</sup> in ambitious current and future space projects.
[Diagnostic significance of telomerase activity and telomere length in endoscopic sample of colorectal cancer]. (1998)

Telomeres are located on both ends of individual chromosomes in eukaryotes. It has been reported that telomerase activity and telomere reduction can be detected in most human cancers. We examined telomerase activity and telomere length in colorectal cancer tissues obtained by colonoscopy. Telomerase activity was examined by the TRAP (telomeric repeat amplification protocol) assay and was detected in 21 of 26 (81%) primary colorectal carcinoma tissues. Two of 9 (22%) colorectal polyp were telomerase positive. Telomere length was analyzed by Southern blotting and there was reduction in telomere lengths in 12 of 15 (80%) primary colorectal carcinoma and 3 of 6 colorectal polyp, compared to the corresponding normal colonic mucosa. Therefore, telomerase activity and telomere length may serve as an useful tool for preoperative cancer diagnosis.
Polymolecular (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Ultra portable LC projector with high-brightness optical system (2000)

In order to realize a high-brightness and high-quality picture for a ultra portable liquid crystal (LC) projector, a high-collection illumination system comprising a polarization converter, a multi-lens, a small-size LC panel with microlens system and new color-optical system, has been developed.
Gold-Induced Unfolding of Lysozyme: Toward the Formation of Luminescent Clusters (2017)

Ion mobility mass spectrometry studies on Aun-Lyz adducts showed gradual unfolding of the protein structure during binding of Au+ to the protein. The change of the charge state envelope in Aun-Lyz from that of Lyz in ESI MS data confirmed the relaxation of the protein structure. This Au+ binding occurs at cysteine sites through the breakage of disulfide bonds and this ruptures the H-bonded folded network structure of the protein leading to ∼30% change in helicity. Nearly 15% loss in the total H-bonding occurred during the attachment of 8 Au to the protein as calculated by a molecular dynamics simulation. Different Aun-Lyz structures were simulated, which confirmed significant unfolding of the protein. The structural insights were used to understand similar unfolding in the solution state as seen via circular dichroism (CD) and Fourier transform infrared (FTIR) spectroscopy. This open structure is indeed necessary to accommodate a cluster core inside a protein cavity during luminescent cluster synthesis. These studies unambiguously establish noble metal binding-induced conformational changes of protein structures to accommodate the clusters.
On the performance of lazy matching in production systems (1990)

Production systems are an established method for encoding knowledge in an expert system. The semantics of produc-tion system languages and the concomitant algorithms for their evaluation, RETE and TREAT, enumerate the set of rule instantiations and then apply a strategy that selects a single instantiation for firing. Often rule instantiations are calculated and never fired. In a sense, the time and space re-quired to eagerly compute these unfired instantiations is wasted. This paper presents preliminary results about a new match technique, lazy matching. The lazy match algorithm folds the selection strategy into the search for instantiations, such that only one instantiation is computed per cycle. The algorithm improves the worst-case asymptotic space com-plexity of incremental matching. Moreover, empirical and
Data from [<sup>89</sup>Zr]ZrDFO-CR011 PET Correlates with Response to Glycoprotein Nonmetastatic Melanoma B–targeted Therapy in Triple-negative Breast Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;There is a need for prognostic markers to select patients most likely to benefit from antibody–drug conjugate (ADC) therapy. We quantified the relationship between pretreatment PET imaging of glycoprotein nonmetastatic melanoma B (gpNMB) with &lt;sup&gt;89&lt;/sup&gt;Zr-labeled anti-gpNMB antibody ([&lt;sup&gt;89&lt;/sup&gt;Zr]ZrDFO-CR011) and response to ADC therapy (CDX-011) in triple-negative breast cancer. First, we compared different PET imaging metrics and found that standardized uptake values (SUV) and tumor-to-heart SUV ratios were sufficient to delineate differences in radiotracer uptake in the tumor of four different cell- and patient-derived tumor models and achieved high standardized effect sizes. These tumor models with varying levels of gpNMB expression were imaged with [&lt;sup&gt;89&lt;/sup&gt;Zr]ZrDFO-CR011 followed by treatment with a single bolus injection of CDX-011. The percent change in tumor volume relative to baseline (% CTV) was then correlated with SUV&lt;sub&gt;mean&lt;/sub&gt; of [&lt;sup&gt;89&lt;/sup&gt;Zr]ZrDFO-CR011 uptake in the tumor. All gpNMB-positive tumor models responded to CDX-011 over 6 weeks of treatment, except one patient-derived tumor regrew after 4 weeks of treatment. As expected, the gpNMB-negative tumor increased in volume by 130 ± 59% at endpoint. The magnitude of pretreatment SUV had the strongest inverse correlation with the % CTV at 2–4 weeks after treatment with CDX-011 (Spearman ρ = −0.8). However, pretreatment PET imaging with [&lt;sup&gt;89&lt;/sup&gt;Zr]ZrDFO-CR011 did not inform on which tumor types will regrow over time. Other methods will be needed to predict resistance to treatment.&lt;/p&gt;&lt;/div&gt;
BEoL Layout Design Considerations to Mitigate CPI Risk (2018)

We present a summary of some of the main Back End of Line (BEoL) design optimization techniques to mitigate Chip Package Interaction (CPI) risk in flip-chip configuration. Optimization techniques include metal tiles right on top of the metal stack at the corner of the die beyond the bumps, diagonal final aluminum cap metal lines under the corner bumps, octagon shape of the pads under the bumps, 80° PSPI angle opening, as well as wider double rail crackstops.