gebhart/patrepeval huggingface dataset:
Biodegradable Polymersomes with Structure Inherent Fluorescence and Targeting Capacity for Enhanced Photo‐Dynamic Therapy (2021)

Abstract Biodegradable nanostructures displaying aggregation‐induced emission (AIE) are desirable from a biomedical point of view, due to the advantageous features of loading capacity, emission brightness, and fluorescence stability. Herein, biodegradable polymers comprising poly (ethylene glycol)‐block‐poly(caprolactone‐gradient‐trimethylene carbonate) (PEG‐P(CLgTMC)), with tetraphenylethylene pyridinium‐TMC (PAIE) side chains have been developed, which self‐assembled into well‐defined polymersomes. The resultant AIEgenic polymersomes are intrinsically fluorescent delivery vehicles. The presence of the pyridinium moiety endows the polymersomes with mitochondrial targeting ability, which improves the efficiency of co‐encapsulated photosensitizers and improves therapeutic index against cancer cells both in vitro and in vivo. This contribution showcases the ability to engineer AIEgenic polymersomes with structure inherent fluorescence and targeting capacity for enhanced photodynamic therapy.
Biomimetic materials design for cardiac tissue regeneration (2013)

Cardiovascular disease is the leading cause of death worldwide. In the absence of sufficient numbers of organs for heart transplant, alternate approaches for healing or replacing diseased heart tissue are under investigation. Designing biomimetic materials to support these approaches will be essential to their overall success. Strategies for cardiac tissue engineering include injection of cells, implantation of three-dimensional tissue constructs or patches, injection of acellular materials, and replacement of valves. To replicate physiological function and facilitate engraftment into native tissue, materials used in these approaches should have properties that mimic those of the natural cardiac environment. Multiple aspects of the cardiac microenvironment have been emulated using biomimetic materials including delivery of bioactive factors, presentation of cell-specific adhesion sites, design of surface topography to guide tissue alignment and dictate cell shape, modulation of mechanical stiffness and electrical conductivity, and fabrication of three-dimensional structures to guide tissue formation and function. Biomaterials can be engineered to assist in stem cell expansion and differentiation, to protect cells during injection and facilitate their retention and survival in vivo, and to provide mechanical support and guidance for engineered tissue formation. Numerous studies have investigated the use of biomimetic materials for cardiac regeneration. Biomimetic material design will continue to exploit advances in nanotechnology to better recreate the cellular environment and advance cardiac regeneration. Overall, biomimetic materials are moving the field of cardiac regenerative medicine forward and promise to deliver new therapies in combating heart disease.
Data from Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;Extracellular adenosine in tumors can suppress immune responses and promote tumor growth. Adenosine deaminase 2 (ADA2) converts adenosine into inosine. The role of ADA2 in cancer and whether it can target adenosine for cancer therapy has not been investigated. Here we show that increased ADA2 expression is associated with increased patient survival and enrichment of adaptive immune response pathways in several solid tumor types. Several ADA2 variants were created to improve catalytic efficiency, and PEGylation was used to prolong systemic exposure. In mice, PEGylated ADA2 (PEGADA2) inhibited tumor growth by targeting adenosine in an enzyme activity–dependent manner and thereby modulating immune responses. These findings introduce endogenous ADA2 expression as a prognostic factor and PEGADA2 as a novel immunotherapy for cancer.&lt;/p&gt;Significance:&lt;p&gt;This study identifies ADA2 as a prognostic factor associated with prolonged cancer patient survival and introduces the potential of enzymatic removal of adenosine with engineered ADA2 for cancer immunotherapy.&lt;/p&gt;&lt;/div&gt;
<title>Challenges of coping with PMD in high-speed WDM optical systems</title> (2001)

PMD is one of the critical hurdles in deploying high capacity fiber optical networks (OC-192 per channel and above). Due to its stochastic and time-varying nature, PMD compensation requires adaptive schemes, using feedback or feed-forward techniques. In this paper we will discuss practical issues and limitations of PMD compensation, as well as recent developments on architecture and feedback schemes.
Excitation function of (p, α) nuclear reaction on enriched 67Zn: possibility of production of 64Cu at low energy cyclotron (2014)

Abstract The potential for production of the medically relevant 64 Cu has been investigated by proton irradiation of highly enriched 67 Zn targets. The excitation function of the 67 Zn( p , α ) 64 Cu a nuclear reaction was measured by the stacked-foil technique up to 30 MeV. The prediction of the TALYS code was also compared to the measured cross section results. Based on the improved database of the 67 Zn( p , α ) 64 Cu reaction, thick target yield as a function of energy was also deduced. Production possibility of 64 Cu is discussed in detail, employing different energy proton beams and with regards to the 61 Cu and 67 Cu contamination levels as a function of the target enrichment level. By using 1 μ A beam intensity, 6.3505 h irradiation time and enriched 67 Zn target ( 64 Zn ≤ 0.5%, 66 Zn ≤ 9%, 67 Zn ≥ 80%, 68 Zn ≤ 10% and 70 Zn ≤ 0.5%), the expected EOB (End Of bombardment) yields are 43.66, 88.80 and 156.14 MBq/ μ A at 12, 15 and 18 MeV proton energies, respectively. Application time-frames were also deduced where the total radio-copper contamination level remains below 1%.
On the Diversity–Multiplexing Tradeoff in Multiple-Relay Network (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper studies the setup of a multiple-relay network in which <emphasis emphasistype="italic"><formula formulatype="inline"><tex Notation="TeX">$K$</tex> </formula></emphasis> half-duplex multiple-antenna relays assist in the transmission between either one or several multiple-antenna transmitter(s) and a multiple-antenna receiver. Each two nodes are assumed to be either connected through a quasi-static Rayleigh-fading channel, or disconnected. We propose a new scheme, which we call <emphasis emphasistype="italic">random sequential</emphasis> (RS), based on the amplify-and-forward relaying. We prove that for general multiple-antenna multiple-relay networks, the proposed scheme achieves the maximum diversity gain. Furthermore, we derive diversity–multiplexing tradeoff (DMT) of the proposed RS scheme for general single-antenna multiple-relay networks. It is shown that for single-antenna two-hop multiple-access multiple-relay <emphasis emphasistype="italic"><formula formulatype="inline"><tex Notation="TeX">$(K &gt; 1)$</tex></formula></emphasis> networks (without direct link between the transmitter(s) and the receiver), the proposed RS scheme achieves the optimum DMT. However, for the case of multiple-access single-relay setup, we show that the RS scheme reduces to the naive amplify-and-forward (AF) relaying and is not optimum in terms of DMT, while the dynamic decode-and-forward (DF) scheme is shown to be optimum for this scenario. </para>
Chemical detection system and related methods (2023)

A chemical detection system includes a frame, an emitter coupled to the frame, and a detector coupled to the frame proximate the emitter. The system also includes a shielding system coupled to the frame and positioned at least partially between the emitter and the detector, wherein the frame positions a sensing surface of the detector in a direction substantially parallel to a plane extending along a front portion of the frame. A method of analyzing composition of a suspect object includes directing neutrons at the object, detecting gamma rays emitted from the object, and communicating spectrometer information regarding the gamma rays. The method also includes presenting a GUI to a user with a dynamic status of an ongoing neutron spectroscopy process. The dynamic status includes a present confidence for a plurality of compounds being present in the suspect object responsive to changes in the spectrometer information during the ongoing process.
Comparison of Dynamic Responses of the THOR-NT and Hybrid III in Offset Frontal Crash Test (2009)

A64 km/h offset frontal crash test was conducted with the THOR-NT and Hybrid III to investigate the responses of both dummies under a crash situation that includes both deformation and rotational behavior of a vehicle. Though the dummies were installed in the driver seat according to the ECE R94 positioning procedure, their postures were slightly different. The head and heels of the THOR-NT were positioned rearward. Similarly, the shoulders and knees were positioned forward compared to the Hybrid-III. Therefore, it is expected that these differences will affect the responses of both dummies. During the tests, both dummies showed similar kinematics, except for the rotation about Z-axis of the head, and the contact situation to the instrument panel of the arms. For the injury measures, the chest acceleration of the THOR-NT showed sharp inclination at 100ms to 120ms, presumed to be caused by the contact between the arms and instrument panel. The initial time history curve of the lap belt force was approximately the same between both dummies; however, the maximum force of the THOR-NT was less than half of the Hybrid III. For this difference, it was strongly presumed that more kinetic energy was absorbed by the knee bolster for the THOR-NT since its longer femur shortened the initial clearance between the knee and knee bolster. In addition, it was also presumed that the difference of the flesh characteristics around the iliac wing between both dummies affected the results. The injury measures of both dummies were compared to the injury criteria specified in FMVSS 208 and ECE R94. As for the results, almost equivalent values between the two dummies were observed. Moreover, as reference, the additional injury measures in the THOR-NT are shown in this paper. The full text of this paper may be found at: http://www-nrd.nhtsa.dot.gov/pdf/esv/esv21/09-0268.pdf For the covering abstract see ITRD E145407.
A POWER COMBINED W-BAND HBT OSCILLATOR TU2B-5 (2000)

In this paper, the development of a power combined W-band heterojunction bipolar transistor (HBT) oscillator is reported. The oscillation frequency is 105.9 GHz, and the output power is +0.6 dBm with a phase noise of -88 dBc/Hz at 1 MHz offset. We believe this is the first report of a W-band fundamental mode power combined oscillator.
THE PREVENTION OF DIABETES MELLITUS (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IRISformer: Dense Vision Transformers for Single-Image Inverse Rendering in Indoor Scenes (2022)

Indoor scenes exhibit significant appearance variations due to myriad interactions between arbitrarily diverse object shapes, spatially-changing materials, and complex lighting. Shadows, highlights, and inter-reflections caused by visible and invisible light sources require reasoning about long-range interactions for inverse rendering, which seeks to recover the components of image formation, namely, shape, material, and lighting. In this work, our intuition is that the long-range attention learned by transformer architectures is ideally suited to solve longstanding challenges in single-image inverse rendering. We demonstrate with a specific instantiation of a dense vision transformer, IRISformer, that excels at both single-task and multi-task reasoning required for inverse rendering. Specifically, we propose a transformer architecture to simultaneously estimate depths, normals, spatially-varying albedo, roughness and lighting from a single image of an indoor scene. Our extensive evaluations on benchmark datasets demonstrate state-of-the-art results on each of the above tasks, enabling applications like object insertion and material editing in a single unconstrained real image, with greater photorealism than prior works. Code and data are publicly released. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> https://github.com/ViLab-UCSD/IRISformer
Viewing DICOM-compliant CT images on a desktop personal computer: use of an inexpensive DICOM receive agent and freeware image display applications. (1999)

Simple-to-use Macintosh-based options to transfer and view images are readily available and easily installed by users with minimal computer expertise.
Dynamic Transcriptional and Epigenetic Regulation of Human Epidermal Keratinocyte Differentiation (2016)

Human skin is maintained by the differentiation and maturation of interfollicular stem and progenitors cells. We used DeepCAGE, genome-wide profiling of histone modifications and retroviral integration analysis, to map transcripts, promoters, enhancers, and super-enhancers (SEs) in prospectively isolated keratinocytes and transit-amplifying progenitors, and retrospectively defined keratinocyte stem cells. We show that >95% of the active promoters are in common and differentially regulated in progenitors and differentiated keratinocytes, while approximately half of the enhancers and SEs are stage specific and account for most of the epigenetic changes occurring during differentiation. Transcription factor (TF) motif identification and correlation with TF binding site maps allowed the identification of TF circuitries acting on enhancers and SEs during differentiation. Overall, our study provides a broad, genome-wide description of chromatin dynamics and differential enhancer and promoter usage during epithelial differentiation, and describes a novel approach to identify active regulatory elements in rare stem cell populations.
Spectral bandwidth limitations of static common-path and single-mirror Fourier transform infrared spectrometers (2016)

Microbolometer arrays allow spectral analysis of infrared light using static Fourier transform spectrometers (sFTS). Here we evaluate limitations of common-path and single-mirror sFTS regarding their spectral bandwidth.
Synthesis and properties of poly(arylene ether)s based on 3‐pentadecyl 4,4'‐biphenol (2016)

Abstract A new biphenol, 3‐pentadecyl 4,4′‐biphenol, was synthesized starting from 3‐pentadecylphenol and was polycondensed with 4,4′‐difluorobenzophenone, 1,3‐bis(4‐fluorobenzoyl)benzene and bis(4‐fluorophenyl)sulfone to obtain poly(arylene ether)s with biphenylene linkages in the backbone and pendent pentadecyl chains. Inherent viscosities and number‐average molecular weights ( M n ) of the poly(arylene ether)s were in the range 0.50 − 0.81 dL g −1 and 2.2 × 10 4 − 8.3 × 10 4 , respectively. Detailed NMR spectroscopic studies of the poly(arylene ether)s indicated the presence of constitutional isomerism which existed because of the non‐symmetrical structure of 3‐pentadecyl 4,4′‐biphenol. The poly(arylene ether)s readily dissolved in common organic solvents such as dichloromethane, chloroform and tetrahydrofuran and could be cast into tough, transparent and flexible films from their chloroform solutions. The poly(arylene ether)s exhibited T g values in the range 35–60 °C which are lower than that of reference poly(arylene ether)s without pentadecyl chains. The 10% decomposition temperatures ( T 10 ) of the poly(arylene ether)s were in the range 410–455 °C indicating their good thermal stability. A gas permeation study of poly(ether sulfone) containing pendent pentadecyl chains revealed a moderate increase in permeability for helium, hydrogen and oxygen. However, there was a large increase in permeability for carbon dioxide which could be attributed to the internal plasticization effect of pendent pentadecyl chains. © 2016 Society of Chemical Industry
Contribution of Direct Heating, Thermal Conduction and Perfusion During Radiofrequency and Microwave Ablation (2007)

Both radiofrequency (RF) and microwave (MW) ablation devices are clinically used for tumor ablation. Several studies report less dependence on vascular mediated cooling of MW compared to RF ablation. We created computer models of a cooled RF needle electrode, and a dipole MW antenna to determine differences in tissue heat transfer.
Universal Profiling of HIV-1 Pol for Genotypic Study and Resistance Analysis Across Subtypes (2011)

A novel protocol was produced to effectively identify and simultaneously generate extensive sequence profiles of pol genes across HIV-1 subtypes. This protocol allows for expeditious and cost-effective mutation detection, genotypic evaluation and viral load determination in multiple HIV-1 subtypes.
Stereochemical studies of adrenergic drugs. Diastereomeric 2-amino-1-phenylcyclobutanols (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemical studies of adrenergic drugs. Diastereomeric 2-amino-1-phenylcyclobutanolsDuane D. Miller, Fu-Lian Hsu, Kadhim N. Salman, and Popat N. PatilCite this: J. Med. Chem. 1976, 19, 1, 180–184Publication Date (Print):January 1, 1976Publication History Published online1 May 2002Published inissue 1 January 1976https://pubs.acs.org/doi/10.1021/jm00223a036https://doi.org/10.1021/jm00223a036research-articleACS PublicationsRequest reuse permissionsArticle Views222Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Education in Medical Physics as an Entry to an Academic Career in the Optics and AI of Medical Imaging (2022)

Optics enters the education of the medical physicist through the teachings of imaging science in the formation of medical images.Such studies include understanding the physics of sources, detector systems, image reconstruction algorithms, noise reduction, image display, and image interpretation (by human or computer/AI).
Spectrally and Spatially Resolved Smith-Purcell Radiation in Plasmonic Crystals with Short-Range Disorder (2017)

An experimental setup based on a modified scanning electron microscope is used to explore fundamental aspects of the coupling of free electrons to plasmonic crystals and localized plasmonic resonances.
HLA Class I Genes: From Structure to Expression, Serology and Function (1985)

HLA class I genes have been isolated from phage and cosmid libraries and assayed by transfection into murine L cells. The transfection step proved to be very important because of the large number of genes (and pseudogenes) in this family. All functional genes characterized so far in this way are "classical" class I genes, i.e. members of the HLA-A, -B or -C families. Three of these have been sequenced (HLA-A3, -Aw24; HLA-Cw3) in addition to the pHLA 12.4 pseudogene. Sequence comparisons indicate, in particular, extreme conservation of the 3' non-coding region between allelic HLA-A locus genes; the general organization of all these genes (8 exons) is very similar. Restriction mapping around the functional genes has been performed to investigate the degree of conservation (e.g. between HLA-A3 regions from 2 different individuals) and examine allelism at the DNA level (e.g. between HLA-A3 and HLA-Aw24 regions). Exon shuffling experiments followed by serological analysis of the expressed product indicate that, as expected, specificities are determined by the first two domains of the molecule. However, further constructs show that as soon as a single exon is exchanged most specific reactivities disappear. CTL analysis of murine cells expressing HLA molecules has run into many difficulties but still holds promise for the study of structure-function relationships in this system.
Influence of Drinking Water on Cognitive Performance of Schoolchildren - CogniDROP (2019)

Question: Water is one of the most important nutrients for physical and mental health. Especially among children, an adequate fluid supply is often insufficient. Preliminary studies indicate that about 17% of 10 to 12 year old children refrain from drinking anything before school starts. This may negatively affect their ability to concentrate. The aim of this interventional study was to investigate short-term effects of an increased water supply affecting the cognitive performance of schoolchildren in everyday conditions.
ChemInform Abstract: Palladium‐Catalyzed Arylation and Acylation of 1‐Benzyloxy‐1,2,3‐triazole Through a Directed ortho Lithiation‐Transmetalation Strategy. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Quantitative Modelling of Deposition of Airborne Molecular Contamination (2019)

The build-up of gaseous contamination from the ambient air on the surface of a wafer as a function of exposure time is quantitatively modelled. The calculation shows that the transport in the ambient air plays a major role.
Coherent polarization locking with near-perfect combining efficiency (2006)

We demonstrate the coherent locking of two orthogonal polarized lasers by using polarization selective loss. The two orthogonal polarizations are locked coherently to produce a resultant polarization state that sees minimal cavity loss. In contrast to the Michelson locking schemes, our scheme has the advantage of easy tunability, which helps to routinely achieve near-perfect (>99%) combining efficiency even when the power of the two arms is highly imbalanced and is varied from a power ratio of unity to >5. We also demonstrate an interesting phenomenon in which a miniscule injection of an antiphase field component from one arm into another can significantly inhibit the locking mechanism.