gebhart/patrepeval huggingface dataset:
Expression of Cutaneous Lymphocyte–Associated Antigen and E‐selectin Ligand by Circulating Human Memory CD4+T Lymphocytes Specific for Herpes Simplex Virus Type 2 (2004)

Virus-specific memory T lymphocytes traffic to sites of viral infection. Herpes simplex virus (HSV) type 2-specific CD4(+) and CD8(+) T lymphocytes differ with regard to their homing kinetics to infected tissues. We studied the expression of cutaneous lymphocyte-associated antigen (CLA) and E-selectin ligand (ESL) by HSV-2-specific CD4(+) T lymphocytes. Virus-reactive T lymphocytes were identified ex vivo by CD154 or interferon-gamma up-regulation. We detected selective expression of CLA by HSV-2-reactive CD4(+) T lymphocytes, but at levels lower than those we previously observed for CD8(+) T lymphocytes. Short-term HSV-2-reactive CD4(+) lines generated from peripheral-blood mononuclear cells preferentially express CLA, compared with cytomegalovirus- or influenza-specific cells. CLA is expressed by HSV-2-reactive cells that are initially CLA negative before restimulation. Short-term culture-expanded HSV-2-specific CD4(+) T lymphocytes also selectively express ESL. These findings have implications for the optimization of vaccines for HSV and other cutaneous pathogens.
Interactive physically-based cloud simulation (2003)

Artificial clouds play an important role in the computer generation of natural outdoor scenes. Realistic modeling and rendering of such scenes is important for applications in games, military training simulations, flight simulations, and even in the creation of digital artistic media. We propose a model for simulating cloud formation based on an efficient computational fluid solver We combine the fluid solver with a model of the natural processes of cloud formation, including buoyancy, relative humidity, and condensation. This allows us to simulate the formation and growth of clouds at interactive rates.
ChemInform Abstract: (.+‐.)‐(3aR*,6S*,7S*,14aR*)‐2,3,3a,7,8,9,10,11,12,13,14,14a‐ Dodecahydro‐1H,6H‐3a,6‐epoxy‐7,14a‐methanocyclopentacyclotridecen‐15‐ one. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High-Sensitivity in Dielectrophoresis Separations (2020)

The applications of dielectrophoretic (DEP) techniques for the manipulation of cells in a label-free fashion within microfluidic systems continue to grow. However, a limited number of methods exist for making highly sensitive separations that can isolate subtle phenotypic differences within a population of cells. This paper explores efforts to leverage that most compelling aspect of DEP-an actuation force that depends on particle electrical properties-in the background of phenotypic variations in cell size. Several promising approaches, centering around the application of multiple electric fields with spatially mapped magnitude and/or frequencies, are expanding the capability of DEP cell separation.
Generation from tumor-bearing mice of lymphocytes with in vivo therapeutic efficacy. (1987)

Systemic transfer of sensitized lymphocytes can effectively mediate the regression of established tumors. However, virtually all prior experimental applications of this approach have utilized lymphocytes from animals that have been immunized to reject tumor challenge. A similar source of cells is not available in the human. With the use of a weakly immunogenic murine tumor, MCA 105, we demonstrate here that following in vitro sensitization (IVS) with viable tumor cells and interleukin 2, the nontherapeutic lymphoid cells from mice bearing a progressively growing tumor acquired antitumor reactivity capable of mediating the regression of established pulmonary metastases. Although the IVS system induced nonspecific lymphokine-activated killer-like cytotoxic activity from lymphoid cells of normal as well as tumor-bearing mice, therapeutically active cells could only be generated from cultures initiated with lymphoid cells from tumor-bearing animals, indicating that the IVS was a secondary in vitro immune response. Without other treatment, the IVS cells could mediate antitumor effects. However, low doses of exogenous interleukin 2 administration could enhance their therapeutic efficacy. By in vivo T cell subset depletion with monoclonal antibodies, the primary effector cells were identified as belonging to cytotoxic/suppressor T cell lineage expressing the Lyt-2 phenotype. In addition, these therapeutic effector cells could be further expanded in numbers in vitro with continuous stimulation by tumor cells in the presence of interleukin 2. Compared to the number of cells initiating the culture, as many as 126 times the number of cells were obtained after 9 days of IVS followed by in vitro expansion for an additional 5 days. Studies on the kinetics of the occurrence of the pre-effector lymphocytes during tumor growth revealed that they were readily obtained from draining lymph nodes of mice with a broad range of tumor burdens as well as durations of tumor growth. The ability to generate and expand, in vitro, therapeutically active lymphocytes from tumor-bearing hosts has important implications for cellular therapy of human cancers.
LEARNING FIBEROPTIC OROTRACHEAL AND NASOTRACHEAL INTUBATION (1999)

S169 INTRODUCTION: The learning curves for fiberoptic orotracheal endoscopy [1] and also for fiberoptic nasotracheal endoscopy, [2] have been studied. However, there is no information on how learning one type of intubation first, affects learning the other type subsequently. We studied the extent to which learning fiberoptic orotracheal intubation first, helped anesthesiologists learn fiberoptic nasotracheal intubation, and vice versa. METHODS: The investigation was approved by South Birmingham Research Ethics Committee and patients gave informed consent. After practice on a bronchial tree model, 24 anesthesiologists were randomly allocated to receive fiberoptic training either by performing 10 nasotracheal intubations first followed by 10 orotracheal intubations (nasal first/oral second group) or by performing 10 orotracheal intubations first followed by 10 nasotracheal intubations (oral first/nasal second group). Anesthesia comprised glycopyrrolate, fentanyl, propofol, atracurium, oxygen and isoflurane. Fiberoptic endoscopies were conducted in a standard manner, with the aid of an endoscopic video camera system, under the supervision of an experienced instructor, as has been described previously. [2] Endoscopy time was taken as the time required to move the fiberscope from the nostril or lips to the carina. Data were analyzed by ANOVA (p < 0.05 was considered significant). RESULTS: The learning curves for the nasal first/oral second group and the oral first/nasal second group are shown in Figure 1:Figure 1Performing nasal endoscopy second (average 70 seconds) took significantly less time than performing it first (87s), and performing oral endoscopy second (34s) took significantly less time than performing it first (46s). The mean total endoscopy time (both nasal and oral) for the nasal first/oral second group (1223s, SD 181) was not significantly different from the mean total endoscopy time for the oral first/nasal second group (1180s, SD 190). CONCLUSION: Learning one type of fiberoptic endoscopy first significantly reduces endoscopy performance times when learning the second type. The total times required for the two groups to complete their 20 endoscopies is similar, whether oral or nasal intubations are performed first.
Supercritical CO2-assisted deposition of NiO on (101)-anatase-TiO2 for efficient facet engineered photocatalysts (2018)

Deposition of NiO on the (101) facet of anatase nanocrystals by the SFCD route yields nanocomposites more efficient than pure anatase TiO<sub>2</sub> for the photodecomposition of both anionic and cationic dyes.
E.P.R. STUDY OF THE ACTION OF NITROSO DERIVATIVES ON ORGANOPHOSPHORUS COMPOUNDS. II1—CASE OF 2-METHYL, 2-NITROSOPROPANE (M.N.P.) (1977)

Abstract Nitroxides bearing α-phosphorus substituents are obtained by adding various organophosphorus compounds to solutions of 2-methyl, 2-nitroso propane (M.N.P.); furthermore, the action of nitric oxide on tetraethylpyrophosphite provides the first example of an αα' diphosphorylnitroxide. The nitroxides are identified by E.S.R. and mechanisms are proposed to explain their formation. The present work clearly shows that M.N.P. is not a good scavenger with which to study the radical reactions involving organophosphorus.
P3–311: Sumo modification of natively unfolded proteins tau and alpha–synuclein (2006)

Sumoylation is an important post–translational modification that provides a rapid and reversible means for controlling the activity, subcellular localization and stability of target proteins. We have examined the covalent attachment of the small ubiquitin–like modifier (SUMO) proteins to tau and α–synuclein, two natively unfolded proteins that define several neurodegenerative diseases. Both brain proteins were preferentially modified by SUMO1, as compared to SUMO2 or SUMO3. Tau contains two SUMO consensus sequences and mutational analyses identified lysine K340 as the major sumoylation site. Although both tau and α–synuclein are targets for proteasomal degradation, only tau sumoylation was affected by inhibitors of the proteasome pathway. Tau is a microtubule–associated protein whose ability to bind and stabilize microtubules is negatively regulated by phosphorylation. Treatment with either the phosphatase inhibitor, okadaic acid, or the microtubule depolymerizing drug, colchicine, upregulated tau sumoylation. This suggests that SUMO modification may preferentially target a free soluble pool of the substrate. These findings reveal a new, possibly regulatory, modification of tau and α–synuclein which may also have implications for their pathogenic roles in neurodegenerative diseases.
Capacity Maximizing Adaptive Subcarrier Selection in OFDM with Limited Feedback (2005)

We propose an efficient adaptive subcarrier selection scheme, in which the active subcarriers and their modulation and coding schemes (MCSs) are selected at the receiver, and subsequently conveyed to the transmitter using limited feedback We theoretically show that capacity maximization can be achieved by selecting subcarriers with highest signal-to-noise ratios (SNRs) and adapting the number of active subcarriers according to channel environments. Furthermore, an ordering based adaptive subcarrier selection algorithm is proposed to select the optimal active subcarriers with low complexity. Numerical results show that the proposed adaptive subcarrier selection scheme provides higher capacity than that obtained by water-filling approaches, even with limited feedback.
Medical Honey and Silver Dressings Do Not Interfere with Each Other's Key Functional Attributes. (2014)

Altogether, these data suggest that these 2 classes of dressings do not interfere with each other. Clinical evidence is still required to fully validate these findings.
Long-term complications, extraintestinal manifestations, and mortality in adult Crohnʼs disease in population-based cohorts (2010)

CD is frequently associated with disease complications and extraintestinal conditions. Whether the impact of changing treatment paradigms with increased use of immunosuppressives and biologic agents can reduce disease complications and associated conditions is unknown.
Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non-Hodgkin lymphoma: a single-institution study of 200 patients (2000)

High serum concentrations of vascular endothelial growth factor (S-VEGF) and basic fibroblast growth factor (S-bFGF) are associated with unfavorable clinical characteristics in cancer. The combined effect of S-VEGF and S-bFGF on the survival of 200 patients with non-Hodgkin lymphoma (NHL) was studied. High S-VEGF and S-bFGF at diagnosis were associated with poor survival with the medians, the highest tertiles, or the highest quartiles as the cutoff values. The highest prognostic power was obtained when S-VEGF and S-bFGF were examined as a combination. Patients who had both S-VEGF and S-bFGF within the highest quartiles had only a 21% 5-year survival rate in contrast to a 64% 5-year survival rate among patients with both factors within the 3 lowest quartiles (P <.0001). Simultaneous elevation of S-VEGF and S-bFGF was associated with poor survival in different grades of lymphomas and in the largest histologic subgroup, the large-cell diffuse and immunoblastic lymphomas. S-VEGF (relative risk [RR], 1.83; P =.019) and S-bFGF (RR, 2.02; P =.0049) had independent influences on survival in multivariate models when tested together with the components of the International Prognostic Index (IPI). Patients with both S-VEGF and S-bFGF within the highest quartiles had nearly 3 times higher risk for death (RR, 2.90; 95% confidence interval [CI], 1.56-5.40; P =.0008) than the rest of the patients. This RR was higher than the relative risks associated with any of the components of the IPI in the same model. The authors conclude that the combination of S-VEGF and S-bFGF is a powerful prognostic variable in NHL. (Blood. 2000;96:3712-3718)
Dietary manipulation of haemolytic Escherichia coli populations in porcine postweaning colibacillosis (1997)

Postweaning colibacillosis in piglets is associated with proliferation and colonisation of β-haemolytic entertoxigenic Escherichia coli in the small intestine. The pathogenesis of this disease is complex, with dietary composition being an important contributing factor. In this experiment the interaction between dietary fibre and intestinal β-haemolytic E. coli populations was studied in 33 experimentally infected newly-weaned piglets. A source of soluble fibre (guar gum) was added to the base diet (cooked rice/ animal protein) to increase the dietary soluble fibre content from 1 to 6% on a dry matter basis. The base diet and the guar gum diet were fed to a separate group of piglets for a week from weaning. Experimental inoculation with haemolytic E. coli took place 48 hours after weaning, and all intestinal samples were taken 6-7 days postweaning. Pigs fed the guar gum diet had significantly higher (p&lt;0.05) number of colony-forming units (CFU) of β-haemolytic E. coli per gram of mucosal scraping at 50% along the length of the small intestine (8.0 x 10 9 compared to 1.3 x 10 4 CFU/gram mucosal scraping). No significant differences in haemolytic E. coli numbers were found in the large intestine between diets. Addition of guar gum to the base diet also resulted in reduced weight gain after weaning (p&lt;0.0001). Soluble fibre in the diet appears to be detrimental to growth and health of pigs in the first week postweaning.
Supplementary Figure S2 from USP9X Downregulation Renders Breast Cancer Cells Resistant to Tamoxifen (2023)

&lt;p&gt;Figure S2. QPCR validation of ChIP-seq data at 45 minutes ligand treatment. (A) Genome browser snapshots of ERÃŽÂ± chromatin binding events at the RARA and NRIP1 loci. Cells were ligand treated for 48 hours, prior to fixation. shGFP (blue) and shUSP9X (red) conditions were tested. Tag count and genomic coordinates are shown. (B) ERÃŽÂ± ChIP-QPCR validation of the genomic locations, indicated in A. Cells were ligand treated during 45 minutes prior to fixation. shGFP (white) and shUSP9X (black) conditions were tested. Enrichment over negative control region was assessed. Error bar shows SD values from triplicate measurements.&lt;/p&gt;
Polymer-Based Photonic Phased-Array Antenna System Based on Detector-Switched Optical Blass Matrix True-Time Delay Steering (2000)

This paper reports progress on the substrate guided wave optical true-time delay technique for photonic phase array antenna. Presented is a new optical TTD module design, and the work for PAA system demo. Like other photonic PAA technique, our structure can provide ultra-wide instantaneous bandwidth for PAA, without beam squint, which means when you change microwave frequency, the steering angle will not change. In addition, the optical beamforming network will have very high package density (2.5 delay lines/cmA2) and low weight. It will be more reliable and be able to avoid the electromagnetic pulse attack. Can easily work at high RF frequency, especially at millimeter wave, which is very difficult for electrical method, because no practical microwave transmission line exists. Photonic PAA can let us put all the signal processing unit in some control center, and transfer the signal to remote antenna head through fiber optic link.
Mandarin Accent Analysis Based on Formant Frequencies (2007)

Accent analysis for Mandarin Chinese based on formant frequencies is presented in this paper. Five monophthongs [a, o, e, i, u] of 430 speakers across eight accents were analyzed with univariance analysis of variance (UNIANOVA). The results show that accent has significant influence on the second formant frequency of monophthongs [o, i, u] and has no obvious influence on the formant frequencies of monophthong [a]. In addition, accent has no obvious influence on the first and the third formant frequencies of all five monophthongs.
Magnetic Design Considerations for High-Power Wireless Charging Systems (2022)

This article proposes methods of predicting and preventing thermal failure within high-power ferrite structures of electric vehicle (EV) wireless charging inductive power transfer (IPT) by improving their ferrite layouts. A high-power IPT magnetic design suitable for wirelessly charging an EV at 50 kW using a heuristic approach is presented, where the chosen design achieves reduced heating within the magnetic structure. Recommendations are made that both avoid ferrite fracturing due to magnetic hotspots and cause temperature differentials across ferrite tiles, and regarding airgap distribution between ferrite tiles to reduce loss-inducing circulating flux within the ferrite structure without reducing coupling. Power transfer was simulated in ANSYS and PLECS under misaligned conditions, and validated experimentally with 93.7% system efficiency. Thermal tests performed under rated volt-amps found the magnetics temperatures (after 30 min) could be reduced from 168 to 67 °C using an improved magnetic layout that reduced the thermal gradients within the ferrite tiles by 70%. Leakage fluxes were targeted and validated to be below 15 μT, 950 mm from the center of the vehicle under rated power and worst-case misaligned conditions.
Electrophoresis of Cytoplasmic Molecules Through Gap Junctions by Externally Applied Electric Fields (1989)

External electric fields are efficiently conducted into the cytoplasmic interior of extended chains of cells that are electrotonically coupled by gap junctions. For chains of cells or tissues that are much longer than their electrical length constant, the cytoplasmic electric field within the center of the ensemble is identical in magnitude to the externally applied field. Over a period of time, this internal electric field should cause a intercellular redistribution of charged molecules that are permeant to gap junctions, within the coupled tissue. This prediction was confirmed experimentally by observing the directed migration of 6-carboxyfluorescein (negatively charged) within the electrotonically coupled lateral giant neurons of a crayfish nerve cord under the influence of externally applied DC electric fields. To determine whether such redistributions could occur in developing epithelial tissues, hydra were exposed to DC electric fields, after charged fluorescent dyes had been loaded into their ectoderm. In this electrotonically coupled tissue, the fluorescent dyes also underwent an electrophoretic redistribution in response to externally applied fields. To facilitate the future use of electric fields as an experimental means to redistribute intracellular constituents in developing tissues, mathematical relationships are presented that predict the time course and steady-state concentration profiles of molecules under-going intercellular electrophoresis.
Expedient synthetic routes to [3H]-D-3-azido-3-deoxy-myo-inositol and D-3-azido-3-deoxy-myo-inositol 2,4,5-trisphosphate (1992)

Expedient routes to a tritiated derivative of the v-sis oncogene-transformed cell specific growth inhibitor 3-azido-3-deoxy-myo-inositol and the unlabelled 2,4,5-trisphosphate derivative are described together with the effects of the latter compound in binding to the IP3 receptor.
Thermal stability and in-situ XRD analysis of AlCoCrCuFeNi high entropy alloy thin films (2009)

International audience
Frequency Swapping Using an Optical Switch with Embedded Mach-Zehnder Structures for Wavelength-Converted Optical Signal Routing Without Lightsources (2009)

We proposed and experimentally investigated a frequency swapping technique for two lightwaves by using a LiNbO3 optical switch where only Mach-Zehnder structures were nested. 10-GHz opposite frequency shifts for two lightwaves were successfully obtained.
A Randomized Trial to Assess the Efficacy and Safety of ABT-126, a Selective α7 Nicotinic Acetylcholine Receptor Agonist, in the Treatment of Cognitive Impairment in Schizophrenia (2016)

ABT-126 demonstrated a procognitive effect in nonsmoking subjects, particularly in verbal learning, working memory, and attention.
Publisher Correction: Mice repeatedly exposed to Group-A β-Haemolytic Streptococcus show perseverative behaviors, impaired sensorimotor gating, and immune activation in rostral diencephalon (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Association of the Timing of Puberty with a Chromosome 2 Locus (2008)

The pericentromeric region of chromosome 2 harbors a gene predisposing to pubertal delay in multiply affected pedigrees. Our data suggest that this locus may be a component of the internal clock controlling the timing of the onset of puberty.