gebhart/patrepeval huggingface dataset:
Thymosin Beta‐4 Is Elevated in Women With Heart Failure With Preserved Ejection Fraction (2017)

We show that plasma TB4 is elevated in women with HFpEF and has prognostic information. Because TB4 can preserve EF in animal studies of cardiac injury, the relation of endogenous, circulating TB4 to X chromosome biology and differential outcomes in female heart disease warrants further study.
Lightweight container-based OpenEPC deployment and its evaluation (2016)

The Network Function Virtualization (NFV) paradigm has become mature enough for network operators to start migrating their core architectures to it. NFV presents numerous advantages over the traditional hardware-centric approach in terms of cost, versatility, time-to-market and ease of deployment. Another technology that is experiencing rapid adoption is virtualization using containers. This technology allows the implementation of a virtualized environment which is very close to that obtained from a virtual machine (VM) hypervisor but without the overhead of running multiple operating systems (OSs) on a single machine, resulting in a significant performance boost. Given this background it is natural to seek solutions combining these two approaches. In our case we are interested in deploying OpenEPC, an EPC implementation developed by Core Network Dynamics, using containers. This is, as far as we know, the first container-based deployment of a virtualized LTE core network. In this paper we give a step-by-step description of the process we followed, perform some tests of the resulting platform and analyse its performance.
Walking Microrobot Mechanism with an Exoskeleton (2000)

A walking robot, 40mm × 25mm × 15mm, with an exoskeleton like the structure of an insect has been developed. This exoskeletal mechanism consists of several copper plates and polyimide hinges, and is fabricated using a micromachining technology and a paper folding technique. The electromagnetic actuators permit the hinges of the exoskeleton to bend elastically without friction. This results in converting the vertical motion of the electromagnetic actuators into the lateral walking motion of the robot. Both the electromagnetic force of the actuators and the elastic force of the hinges are proportional to the square of the characteristic length of a robot. This means that an exoskeletal mechanism is suitable for downsizing a movable robot.
Towards On-Chip Self-Referenced Frequency-Comb Sources Based on Semiconductor Mode-Locked Lasers (2019)

Miniaturization of frequency-comb sources could open a host of potential applications in spectroscopy, biomedical monitoring, astronomy, microwave signal generation, and distribution of precise time or frequency across networks. This review article places emphasis on an architecture with a semiconductor mode-locked laser at the heart of the system and subsequent supercontinuum generation and carrier-envelope offset detection and stabilization in nonlinear integrated optics.
Palladium Complexes of 1,3,5,7-Tetramethyl-2,4,8-trioxa-6-phenyl-6-phosphaadamantane:  Synthesis, Crystal Structure and Use in the Suzuki and Sonogashira Reactions and the α-Arylation of Ketones (2004)

Palladium complexes of 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phosphaadamantane were prepared and characterized with Pd[1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phosphaadamantane](2).dba shown to be an effective catalyst for use in the Suzuki and Sonogashira reactions and the alpha-arylation of ketones. Couplings using this versatile complex proceeded in excellent yields under mild conditions.
Total hip replacement using the APR II system (1991)

The APR hip system was originally designed to allow cementless fixation of hip arthroplasty after the poor results of cemented arthroplasty were noted in younger, more active patients. The APR II system is the next generation in this line of proximally porous-coated titanium implants. The anatomic proximal bow and numerous size options maximizes fit of the prosthesis to the cortical bone of the proximal femur, which, along with the porous-coated medial collar, allows for excellent proximal fixation of the prosthesis to bone. Several distal sleeve options allow for excellent fill of the femoral diaphysis to maintain proper alignment and reduce toggle. A proximally grit-blasted stem, specifically designed for cemented fixation, allows for symmetrical cement columns via proximal methacrylate spacers and a distal centralizer. The technique used by the designing surgeon of the APR system (LDD) to produce accurate and reproducible cemented and cementless hip arthroplasty is described in a step by step fashion. The radiographic evaluation of cementless arthroplasty and specific recommendations for when to use cement fixation are also included.
Live Organism Toxicity Monitoring: Signal Analysis (1999)

Live organisms offer the opportunity to monitor water resources for toxic conditions by measuring changes in their established behavioral and physiological responses. The U.S. Army Center for Environmental Health Research uses fish ventilatory pattern analysis to monitor aquatic environments for toxic conditions. The Center and APL have initiated an exploratory analysis of data from a series of controlled, single-substance validation tests being conducted at Fort Detrick, Maryland. This article presents the results of some preliminary analyses and outlines future directions for follow-on studies.
High bandwidth multimode fiber links using subcarrier muitiplexing in vertical-cavity surface-emitting lasers (2002)

Summary form only given. There is currently much interest in low-cost high-speed and short-haul links for local area networks and computer interconnect applications, with standards bodies such as those setting the Gigabit Ethernet standard now considering transmission rates in excess of 1 Gbit/s. Because of cost, particular emphasis has been placed on the use of multimode fiber (MMF) links using vertical-cavity surface-emitting lasers (VCSELs). With increasing data rates however the achievable link lengths become limited due to the modal bandwidth of the MMF. Efforts to overcome this limitation have included the use of wavelength-division multiplexing, multilevel modulation and restricted mode launches. In this paper, however we believe we describe for the first time how subcarrier multiplexing (SCM) techniques can be used to allow link transmission significantly in excess of the specified fiber bandwidth. The technique is robust and has been assessed using a representative range of fibres. A series of 200-Mbit/s channels with carrier frequencies of up to more than twenty times the 3-dB fiber bandwidth have been successfully used, the maximum being limited by the electronics currently available.
A novel annular ring design for improved plated-thru-hole impedance matching (2017)

A novel and patent-pending [1] routing configuration to address the multi-reflection noise caused by the vertical interconnect viz. plated-through-hole (PTH) is presented in this paper. The PTHs are frequently found in any packaging and printed circuit board (PCB) designs for signaling transition from one lateral layer to another. The reflection noise caused by impedance mismatch ascribed to the over-capacitive nature of PTH structure is notoriously associated to degrade and reduce high-speed link margin. The proposed inventive solution is particularly significant to enable multi-Gbps differential high-speed input/output (HSIO) links, such as USB 3.1 Gen2 and Thunderbolt 3 with frequencies running beyond 10Gbps. Though the modeling and simulation analysis conducted and presented in this paper focused on package PTH, the invention is applicable to package ball-grid-array (BGA) pad as well as printed circuit board (PCB) PTH, since each structure produces the same electrical impairment fundamentally. 3-dimensional electromagnetic field modeling and analytical data have shown encouraging data, with up to 20% eye margin improvements thus illustrating the feasibility of this inventive design. This routing scheme is a viable candidate for high-speed interconnect design to enhance highperformance systems.
Experiments on pilot symbol-assisted coherent multistage interference canceller for DS-CDMA mobile radio (2002)

A three-stage coherent multistage interference canceller (COMSIC) employing pilot symbol-assisted (PSA) channel estimation for replica generation of multiple access interference (MAI) is implemented and its performance in the presence of frequency selective multipath fading is experimentally evaluated by a multipath fading simulator. A fast transmission power control (TPC) method suitable for COMSIC is also proposed, in which the signal-to-interference plus background noise power ratio (SIR) at the matched filter (MF) based RAKE receiver is measured to achieve a short TPC delay and the target signal-to-interference ratio value is compensated by an outer loop so that the measured block error rate (BLER) is equal to the prescribed target value. The experimental results show that as expected the COMSIC satisfactorily reduces the MAI even when the number of active users is equal to the spreading factor in a multipath fading environment, and thus, improves the bit error rate (BER) performance in a multiuser environment. The results also show that the proposed fast TPC method with a two-slot delay associated with COMSIC works satisfactorily and the combination of COMSIC and fast TPC significantly decreases the transmission power of a mobile station (required transmission power of a mobile station with COMSIC at the average BER of 10/sup -3/ is decreased by approximately 2.0 (3.0) dB compared with the MF-based RAKE receiver with (without) antenna diversity reception). This extends the cell coverage, battery life, and increases the system capacity in the reverse link.
Indications for Pacemakers, Implantable Cardioverter‐Defibrillators, and Cardiac Resynchronization Therapy (2021)

This chapter includes specific pediatric considerations within the broader categories. Atrioventricular block that develops or worsens during exercise reflects conduction disease in the His–Purkinje system, which warrants implantation of a permanent pacemaker. For patients at high risk of ventricular tachycardia or ventricular fibrillation, but in whom comorbidities preclude immediate internal cardioverter-defibrillator implantation or for whom the risk is transient, a reasonable option is a wearable cardioverter defibrillator. Prospective, randomized, clinical trials have demonstrated that cardiac resynchronization therapy improves left ventricular systolic function, heart failure symptoms, exercise tolerance, quality of life, and survival. Before concluding that permanent pacing is indicated, the physician must carefully assess whether it is in the best interest of the patient. This assessment should include the specifics of the cardiac rhythm disturbance, the patient's general medical status, and the patient's concerns and preferences.
Rigid partitioning techniques for efficiently generating three-dimensional reconstructions from images (2004)

This thesis explores efficient techniques for generating 3D reconstructions from imagery. Non-linear optimization is one of the core techniques used when computing a reconstruction and is a computational bottleneck for large sets of images. Since non-linear optimization requires a good initialization to avoid getting stuck in local minima, robust systems for generating reconstructions from images build up the reconstruction incrementally. A hierarchical approach is to split up the images into small subsets, reconstruct each subset independently and then hierarchically merge the subsets. Rigidly locking together portions of the reconstructions reduces the number of parameters needed to represent them when merging, thereby lowering the computational cost of the optimization. 
We present two techniques that involve optimizing with parts of the reconstruction rigidly locked together. In the first, we start by rigidly grouping the cameras and scene features from each of the reconstructions being merged into separate groups. Cameras and scene features are then incrementally unlocked and optimized until the reconstruction is close to the minimum energy. This technique is most effective when the influence of the new measurements is restricted to a small set of parameters. 
Measurements that stitch together weakly coupled portions of the reconstruction, though, tend to cause deformations in the low error modes of the reconstruction and cannot be efficiently incorporated with the previous technique. To address this, we present a spectral technique for clustering the tightly coupled portions of a reconstruction into rigid groups. Reconstructions partitioned in this manner can closely mimic the poorly conditioned, low error modes, and therefore efficiently incorporate measurements that stitch together weakly coupled portions of the reconstruction. We explain how this technique can be used to scalably and efficiently generate reconstructions from large sets of images.
Paracrine regulation of adrenal steoidogenesis by serotonin in Cushing’s syndrome and 21-hydroxylase deficiency (2018)

International audience
Targeting Host E-Selectin Expression by Antisense Oligodeoxynucleotides as Potential Antiendotoxin Therapy In Vivo (2010)

This study sought to determine if antisense oligodeoxynucleotides would inhibit E-selectin expression, which mediates leukocyte adhesion on endothelial cells, otherwise induced by in vivo endotoxin challenge. Six antisense phosphorothioate oligodeoxynucleotides calculated to bind porcine E-selectin mRNA were tested in porcine aortic endothelial cells. One, ISIS9481, exerted significant inhibition of E-selectin expression induced by tumor necrosis factor-α + endotoxin [lipopolysaccharide (LPS)]. Pigs were challenged with LPS (10 μg/kg) and treated with ISIS9481 (10 mg/kg) (n = 6). Two control groups were used, an antisense inactive in porcine aortic endothelial cells (n = 6) and saline (n = 5), and were combined as control (C = 11). Control pigs challenged with LPS expressed E-selectin in heart, lung, kidneys, and liver, whereas antisense-treated pigs expressed little E-selectin in these tissues. Cardiovascular data indicated that antisense treatment attenuated pathophysiological alterations induced by LPS. Specifically, in control pigs, LPS reduced cardiac output 32% from baseline, increased pulmonary (+116%) and systemic vascular resistances (+16%), and generated neutropenia (from 51,000 at basal to 18,000 polymorphonuclear neutrophils (PMN)/μL after LPS). In antisense-treated pigs, cardiac output decreased only 18%, pulmonary vascular resistance remained unchanged, whereas systemic vascular resistance decreased compared with basal values (-37%). PMN counts remained at 45,000-54,000/μL at 3-4 hours after LPS. These data demonstrate that antisense oligodeoxynucleotides, designed and tested in vitro to interact with 1 gene product, can be developed as either therapeutics or experimental tools in vivo.
High-Porosity Poly(ε-Caprolactone)/Mesoporous Silicon Scaffolds: Calcium Phosphate Deposition and Biological Response to Bone Precursor Cells (2008)

In this study, the fabrication and characterization of highly porous composites composed of poly(epsilon-caprolactone) and bioactive mesoporous silicon (BioSilicon) prepared using salt-leaching and microemulsion/freeze-drying methods are described. The role of silicon, along with porosity, in the scaffolds on calcium phosphate deposition was assessed using acellular in vitro calcification analyses. The presence of bioactive silicon in these scaffolds is essential for the deposition of calcium phosphate while the samples are immersed in simulated body fluid (SBF). Silicon-containing scaffolds produced using salt-leaching methods are more likely to calcify as a consequence of SBF exposure than those produced using microemulsion methods. In vitro proliferation and cell viability assays of these porous composites using human embryonic kidney fibroblast cells indicate that no cytotoxic effects are present in the scaffolds under the conditions used. Preliminary analyses of bone sialoprotein and alkaline phosphatase expression using orthopedically relevant mesenchymal cells derived from bone marrow suggest that such scaffolds are capable of mediating osteoblast differentiation. Overall, the results show that these porous silicon-containing polymer scaffolds enhance calcification, can be considered nontoxic to cells, and support the proliferation, viability, attachment, and differentiation of bone precursor cells.
Genetic Gains in Agronomic and Selected End‐Use Quality Traits over a Century of Plant Breeding of Canada Western Red Spring Wheat (2015)

Canadian Western Red Spring (CWRS) market class is the predominant type of wheat ( Triticum aestivum L.) grown in Canada since the turn of the 20th century. Wheat cultivars ranging from cv. Red Fife to cv. Superb were field tested in a series of 24 replicated trials spanning 19 years in central Saskatchewan, Canada. The objective of this study was to measure the rate of cultivar improvement in light of relatively narrow end‐use quality definitions for the CWRS market class. Regression of cultivar trait means on year of cultivar registration was used to assess the rate of change in yield, productivity traits, and end‐use quality parameters. Yield levels were estimated to be increasing at a rate of approximately 15 kg/ha per year in 1970 and 23 kg/ha per year in 1995. Days to spike emergence and plant height decreased over time. Kernel weight, grain protein concentration, SDS sedimentation volume, farinograph absorption, and dough development time increased over time, whereas farinograph mixing tolerance index and yellow pigment concentration decreased. The results show that improvement in key agronomic and end‐use traits has been achieved in CWRS wheat.
Real-Time Optical Wireless Mobile Communication With High Physical Layer Reliability (2019)

As the use of optical wireless communication (OWC) in industrial production environments is gaining interest, it is necessary to consider the application's challenging requirements with respect to reliability and low latency. In this paper, we first analyze the factors limiting coverage and reliability in OWC. We discuss increased drive signal powers with an optional nonlinear post-equalizer, which improves the signal-to-noise ratio by an additional 3.5 dB. Further, spanning a multiple-input multiple-output (MIMO) channel and exploiting antenna diversity is shown to significantly increase the reliability of the OWC physical layer. The insights obtained from a series of experiments lead to a real-time demonstration of OWC with intrinsically high coverage and reliability. These first real-time results of OWC in an industrial production environment are discussed and physical layer data rates of up to 150 Mb/s with an average latency of <;1 ms are shown.
Nucleic acid-binding polymers as anti-inflammatory agents (2011)

Dead and dying cells release nucleic acids. These extracellular RNAs and DNAs can be taken up by inflammatory cells and activate multiple nucleic acid-sensing toll-like receptors (TLR3, 7, 8, and 9). The inappropriate activation of these TLRs can engender a variety of inflammatory and autoimmune diseases. The redundancy of the TLR family encouraged us to seek materials that can neutralize the proinflammatory effects of any nucleic acid regardless of its sequence, structure or chemistry. Herein we demonstrate that certain nucleic acid-binding polymers can inhibit activation of all nucleic acid-sensing TLRs irrespective of whether they recognize ssRNA, dsRNA or hypomethylated DNA. Furthermore, systemic administration of such polymers can prevent fatal liver injury engendered by proinflammatory nucleic acids in an acute toxic shock model in mice. Therefore these polymers represent a novel class of anti-inflammatory agent that can act as molecular scavengers to neutralize the proinflammatory effects of various nucleic acids.
Supplementary Figure 7 from Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer (2023)

&lt;p&gt;Serial dilution benchmarking of a cancer patient's cfDNA spiked into healthy donor cfDNA using a patient specific panel. (A) Detection power for a range of tumor fractions using our MRD assay. (B) Fraction of replicate dilutions detected by our MRD assay and the median detection power for those samples. (C) Tumor fraction estimation benchmarking for several replicates across a range of tumor fractions.&lt;/p&gt;
Physical properties of (Ba,Sr)Ti03 thin films used for capacitors in microwave applications (2001)

Recently, there has been significant interest in use of (Ba,Sr)Ti03 (BST) thin films for tunable high fkequency (RF and microwave) components. In this paper we discuss the electrical properties of BST thin films grown by metalorganic chemical vapor deposition (MOCVD) as a function of DC bias and frequency at low frequency ( 50%) over the entire fiequency range, making them suitable for these microwave applications. The effect of titanium content, thickness and Pt roughness on dielectric losses and tunability are discussed. Implications for microwave devices are discussed as well. Finally, we report the fabrication of a BST thin film device using a 3-layer mask set to measure electrical properties at RF/microwave fiequencies.
Multi-functional cytotoxic T cell expansion correlates with overall survival after administration of autologous dendritic cell immunotherapy in renal cell cancer patients (2013)

Meeting abstracts AGS-003 is an autologous dendritic cell immunotherapy consisting of matured DC co-electroporated with amplified autologous tumor RNA and synthetic CD40L RNA. A Phase 2 trial evaluated AGS-003-induced T cell immunity in RCC patients in combination with sunitinib. A comprehensive
Iridium(III) Complexes with Orthometalated Quinoxaline Ligands:  Subtle Tuning of Emission to the Saturated Red Color (2005)

Rational design and syntheses of four iridium complexes (1-4) bearing two substituted quinoxalines and an additional 5-(2-pyridyl) pyrazolate or triazolate as the third coordinating ligand are reported. Single-crystal X-ray diffraction studies of 1 reveal a distorted octahedral geometry, in which two dpqx ligands adopt an eclipse configuration, for which the quinoxaline N atoms and the C atoms of orthometalated phenyl groups are located at the mutual trans- and cis-positions, respectively. The lowest absorption band for all complexes consists of a mixture of heavy-atom Ir(III)-enhanced 3MLCT and 3pipi* transitions, and the phosphorescent peak wavelength can be fine-tuned to cover the spectral range of 622-649 nm with high quantum efficiencies. The cyclic voltammetry was measured, showing a reversible, metal-centered oxidation with potentials at 0.76-1.03 V, as well as two reversible reduction waves with potentials ranging from -1.61 to -2.06 V, attributed to the sequential addition of two electrons to the more electron-accepting heterocyclic portion of two distinctive cyclometalated C/N ligands. Complex 1 was used as the representative example to fabricate the red-emitting PLEDs by blending it into a PVK-PBD polymer mixture. The devices exhibited the characteristic emission profile of 1 with peak maxima located at 640 nm. The maximum external quantum efficiency was 3.15% ph/el with a brightness of 1751 cd/m2 at a current density of 67.4 mA/cm2, and the maximum brightness of 7750 cd/m2 was achieved at the applied voltage of 21 V and with CIE coordinates of (0.64, 0.31).
Inhibition of Porphyromonas gingivalis proteinases (gingipains) by chlorhexidine: synergistic effect of Zn(II) (2006)

Chlorhexidine is an effective inhibitor of gingipains, and the inhibition of R-gingipains is enhanced by Zn(II). A mixture of chlorhexidine and Zn(II) may be useful as an adjunct in the treatment of periodontitis and in the post-treatment maintenance of periodontitis patients.