gebhart/patrepeval huggingface dataset:
Automated uplink power control optimization in LTE-Advanced relay networks (2013)

Relaying is standardized in 3rd Generation Partnership Project (3GPP) Long-Term Evolution (LTE)-Advanced Release 10 as a promising cost-efficient enhancement to existing radio access networks. Relay deployments promise to alleviate the limitations of conventional macrocell-only networks such as poor indoor penetration and coverage holes. However, to fully exploit the benefits of relaying, power control (PC) in the uplink should be readdressed. In this context, PC optimization should jointly be performed on all links, i.e., on the donor-evolved Node B (DeNB)-relay node (RN), the DeNB-user equipment (UE) link, and the RN–UE link. This ensures proper management of interference in the network besides attaining a receiver dynamic range which ensures the orthogonality of the single-carrier frequency-division multiple access (SC-FDMA) system. In this article, we propose an automated PC optimization scheme which jointly tunes PC parameters in relay deployments. The automated PC optimization can be based on either Taguchi’s method or a meta-heuristic optimization technique such as simulated annealing. To attain a more homogeneous user experience, the automated PC optimization scheme applies novel performance metrics which can be adapted according to the operator’s requirements. Moreover, the performance of the proposed scheme is compared with a reference study that assumes a scenario-specific manual learn-by-experience optimization. The evaluation of the optimization methods within the LTE-Advanced uplink framework is carried out in 3GPP-defined urban and suburban propagation scenarios by applying the standardized LTE Release 8 PC scheme. Comprehensive results show that the proposed automated PC optimization can provide similar performance compared to the reference manual optimization without requiring direct human intervention during the optimization process. Furthermore, various trade-offs can easily be achieved; thanks to the new performance metrics.
Supplementary Table S1 from Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting (2023)

&lt;p&gt;Sample Information: Table with cell line identities and relevant information for this manuscript.&lt;/p&gt;
Comparison of fast 3D simulation and actinic inspection for EUV masks with buried defects (2009)

Aerial images for isolated defects and the interactions of defects with features are compared between the Actinic Inspection Tool (AIT) at Lawrence Berkeley National Laboratory (LBNL) and the fast EUV simulation program RADICAL. Comparisons between AIT images from August 2007 and RADICAL simulations are used to extract aberrations. At this time astigmatism was the dominant aberration with a value of 0.55 waves RMS. Significant improvements in the imaging performance of the AIT were made between August 2007 and December 2008. A good match will be shown between the most recent AIT images and RADICAL simulations without aberrations. These comparisons will demonstrate that a large defect, in this case 7nm tall on the surface, is still printable even if it is centered under the absorber line. These comparisons also suggest that the minimum defect size is between 1.5nm and 0.8nm surface height because a 1.5nm defect was printable but a 0.8nm was not. Finally, the image of a buried defect near an absorber line through focus will demonstrate an inversion in the effect of the defect from a protrusion of the dark line into the space to a protrusion of the space into the line.
Avoiding Pitfalls in Comparison of Activity and Selectivity of Solid Catalysts for Electrochemical HMF Oxidation (2021)

Electrocatalytic oxidation of 5-hydroxymethylfurfural (HMF) offers a renewable approach to produce the value-added platform chemical 2,5-furandicarboxylic acid (FDCA). The key for the economic viability of this approach is to develop active and selective electrocatalysts. Nevertheless, a reliable catalyst evaluation protocol is still missing, leading to elusive conclusions on criteria for a high-performing catalyst. Herein, we demonstrate that besides the catalyst identity, secondary parameters such as materials of conductive substrates for the working electrode, concentration of the supporting electrolyte, and electrolyzer configurations have profound impact on the catalyst performance and thus need to be optimized before assessing the true activity of a catalyst. Moreover, we highlight the importance of those secondary parameters in suppressing side reactions, which has long been overlooked. The protocol is validated by evaluating the performance of free-standing Cu-foam, and CuCoO modified with NaPO<sub>2</sub> H<sub>2</sub> and Ni, which were immobilized on boron-doped diamond (BDD) electrodes. Recommended practices and figure of merits in carefully evaluating the catalyst performance are proposed.
Supplementary Figure 5 from Inhibitor of Differentiation-1 as a Novel Prognostic Factor in NSCLC Patients with Adenocarcinoma Histology and Its Potential Contribution to Therapy Resistance (2023)

Supplementary Figure 5 from Inhibitor of Differentiation-1 as a Novel Prognostic Factor in NSCLC Patients with Adenocarcinoma Histology and Its Potential Contribution to Therapy Resistance
Figure S4 from PP2A Inactivation Mediated by <i>PPP2R4</i> Haploinsufficiency Promotes Cancer Development (2023)

&lt;p&gt;PTPA and PP2A subunit expression in WT, Ptpa +/gt and Ptpa gt/gt healthy and neoplastic spleens.&lt;/p&gt;
ChemInform Abstract: Rational Development of Practical Catalysts for Aromatic Carbon—Nitrogen Bond Formation (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Linear generator connected to a resonance circuit (2011)

Acupuncture plus moxibustion is significantly superior to simple acupuncture therapy in relieving symptoms of KOA patients, and also has a better post-effect.
Optimization of contrast timing for breath‐hold three‐dimensional MR angiography (1997)

The purpose of this study was to determine the influence of various factors (age, weight, breathing, saline flush) on the contrast kinetics of a test bolus injection for the purpose of calculating the scan delay for optimized contrast-enhanced three-dimensional MR angiography. Initially, the test bolus administration was optimized by evaluating the influence of breathing (breathing versus breath-hold) and the administration of a saline flush after the contrast injection (no flush versus flush) on the kinetics of a 4-ml Gd-DTPA test bolus injection in three healthy volunteers. Subsequently, in 33 patients referred for three-dimensional MR angiography of the renal arteries, test bolus kinetics were correlated to age, weight, and heart rate. In addition, the image quality of the three-dimensional MR angiograms was assessed on a four-point scale with regard to vessel visibility. The administration of a saline flush after the contrast injection significantly shortened the first appearance time (14 versus 16 seconds, P < .05), as well as the time to maximal signal intensity (SI) (6 versus 10 seconds, P < .05) and increased both maximum (67 versus 151 seconds, P < .05) and the SI slope (6.4 versus 20.5 seconds, P < .05). Breath-holding was shown to have no significant affect on the test bolus kinetics. No correlation was found between physiologic parameters and test bolus kinetics in the patient group. Image quality was graded as sufficient for diagnostic purposes in 32 of 33 patients. The contrast travel time from injection site to the vascular system under consideration cannot be predicted based on physiologic parameters. This time interval can be reliably and accurately determined by a test bolus injection of a small volume of contrast agent followed by a saline flush during normal breathing.
A SOI Out-of-Plane Electrostatic MEMS Actuator Based on In-Plane Motion (2022)

This work describes a novel micromechanical structure capable of producing out-of-plane motion from in-plane forces generated by electrostatic microelectromechanical system (MEMS) actuators. The MEMS actuator is fabricated in a commercial silicon-on-insulator (SOI) MEMS process and is anchored at two distinct locations through a pair of beams with a relatively low stiffness in the vertical direction. A comb-drive, whose fixed and moveable fingers are implemented in the same layer with a uniform thickness, is employed to create an attractive electrostatic force. This in-plane electrostatic force rotates the actuator along an axis defined by the anchors, which results in the vertical motion of a suspended platform. Due to the simple structure of the actuator, it can be readily manufactured with standard bulk micromachining processes. Experimental results demonstrate that the actuator can provide <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$1.02~\mu \text{m}$ </tex-math></inline-formula> of vertical displacement at a resonant frequency of 395 Hz when it is excited in air by a 10 V AC signal, while the displacement can be considerably increased in vacuum. It is further shown that the functionality of the actuator is not dependent on the type of excitation voltage; therefore, it can produce a <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$3.09~\mu \text{m}$ </tex-math></inline-formula> static out-of-plane motion when excited by a 40 V DC voltage. A comprehensive comparison to the published works in the literature indicates that the proposed actuator is the only SOI electrostatic MEMS actuator with a relatively thick structural layer, i.e., <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$10~\mu \text{m}$ </tex-math></inline-formula> , that can provide out-of-plane motion at low actuation voltage reported to date. [2022-0069]
The diagnostic use of monoclonal antibodies in a variety of dermatologic conditions (1983)

Monoclonal antibodies have been used to characterize subpopulations of lymphocytes in a variety of dermatologic conditions by immunofluorescence and immunoperoxidase staining. Various clinical presentations of cutaneous T-cell lymphoma have been shown to be neoplastic expansions of helper T-lymphocytes. Immunoperoxidase studies using subset-specific monoclonal antibodies have allowed the differentiation of patients with cutaneous T-cell lymphoma from lymphocytoma cutis and B-cell lymphomas secondarily involving the epidermis. Increased numbers of OKT-6 positive Langerhans' cells in the dermal infiltrates of patients with cutaneous T-cell lymphoma may be another immunocytological marker of this disease. Studies done on circulating lymphocytes of patients with psoriasis and pemphigus vulgaris have shown normal ratios of T-cell subsets in patients with psoriasis and an expansion of the helper T-cell subset in an untreated patient with pemphigus. Immunofluorescence and immunoperoxidase techniques used in conjunction with highly specific monoclonal antibodies have been shown to be valuable for histopathologic study of dermatologic diseases.
Convolutional Mesh Autoencoders for 3D Face Representation (2018)

Convolutional neural networks (CNNs) have achieved state of the art performance on recognizing and representing audio, images, videos and 3D volumes; that is, domains where the input can be characterized by a regular graph structure. However, generalizing CNNs to irregular domains like 3D meshes is challenging. Additionally, training data for 3D meshes is often limited. In this work, we generalize convolutional autoencoders to mesh surfaces. We perform spectral decomposition of meshes and apply convolutions directly in frequency space. In addition, we use max pooling and introduce upsampling within the network to represent meshes in a low dimensional space. We construct a complex dataset of 20,466 high resolution meshes with extreme facial expressions and encode it using our Convolutional Mesh Autoencoder. Despite limited training data, our method outperforms state-of-the-art PCA models of faces with 50% lower error, while using 75% fewer parameters.
A Multicenter Case-control Study of the Effect of Acute Rejection and Cytomegalovirus Infection on Pneumocystis Pneumonia in Solid Organ Transplant Recipients (2018)

PCP was mostly a late-onset disease occurring after complete course of prophylaxis, particularly among patients with CMV infection or allograft rejection. PCP is associated with significant allograft loss. Extended prophylaxis targeting recipients with allograft rejection or CMV infection may reduce the risk of PCP.
Arabidopsis Is Not a Weed, and Mostly Not a Good Model for Weed Genomics; There Is No Good Model for Weed Genomics (2009)

This chapter contains sections titled: Introduction: Arabidopsis and Weediness Questions about Weeds—Can Arabidopsis Genomics Answer Them? The Misdirected Approach in Using Arabidopsis to Elucidate New Herbicide Targets Arabidopsis Genomics Can Help in Dealing with Transgene Flow—In a Limited Manner Lessons to Be Learned References
Plastic–PDMS bonding for high pressure hydrolytically stable active microfluidics (2009)

We explore the application of organofunctional silanes for bonding plastic substrates to PDMS membranes. Such devices would enable actuated membrane microfluidics in plastic devices. Bond strength degradation in aqueous environments can be reduced by using bis-silanes with larger alkoxy end groups to promote organofunctional bond formation with the plastic substrate. Hydrolytic failure can also result from low silane crosslink density or interface hydrophilicity. A test device consisting of three-valve peristaltic pumps is fabricated out of polycarbonate (PC) and bonded to PDMS through isopropoxy modified bis-trimethoxy-silyl-propyl-amine. Valves operated up to 60 psi in aqueous environments without failure. Solutions of DI water and 1 M HCl were also pumped through the device via peristaltic actuation at 18 psi for 2 weeks without bond failure. 1 M NaOH was also tested but resulted in bond failure after 115 hours.
Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA (2021)

The primary objective of the FDA-led Sequencing and Quality Control Phase 2 (SEQC2) project is to develop standard analysis protocols and quality control metrics for use in DNA testing to enhance scientific research and precision medicine. This study reports a targeted next-generation sequencing (NGS) method that will enable more accurate detection of actionable mutations in circulating tumor DNA (ctDNA) clinical specimens. To accomplish this, a synthetic internal standard spike-in was designed for each actionable mutation target, suitable for use in NGS following hybrid capture enrichment and unique molecular index (UMI) or non-UMI library preparation. When mixed with contrived ctDNA reference samples, internal standards enabled calculation of technical error rate, limit of blank, and limit of detection for each variant at each nucleotide position in each sample. True-positive mutations with variant allele fraction too low for detection by current practice were detected with this method, thereby increasing sensitivity.
Anti-inflammatory Effects of Schisandra chinensis (Turcz.) Baill Fruit Through the Inactivation of Nuclear Factor-κB and Mitogen-activated Protein Kinases Signaling Pathways in Lipopolysaccharidestimulated Murine Macrophages (2014)

SF may be useful for the treatment of various inflammatory diseases.
Characterization and engineering of a plastic-degrading aromatic polyesterase (2018)

Poly(ethylene terephthalate) (PET) is one of the most abundantly produced synthetic polymers and is accumulating in the environment at a staggering rate as discarded packaging and textiles. The properties that make PET so useful also endow it with an alarming resistance to biodegradation, likely lasting centuries in the environment. Our collective reliance on PET and other plastics means that this buildup will continue unless solutions are found. Recently, a newly discovered bacterium, <i>Ideonella sakaiensis</i> 201-F6, was shown to exhibit the rare ability to grow on PET as a major carbon and energy source. Central to its PET biodegradation capability is a secreted PETase (PET-digesting enzyme). Here, we present a 0.92 Å resolution X-ray crystal structure of PETase, which reveals features common to both cutinases and lipases. PETase retains the ancestral α/β-hydrolase fold but exhibits a more open active-site cleft than homologous cutinases. By narrowing the binding cleft via mutation of two active-site residues to conserved amino acids in cutinases, we surprisingly observe improved PET degradation, suggesting that PETase is not fully optimized for crystalline PET degradation, despite presumably evolving in a PET-rich environment. Additionally, we show that PETase degrades another semiaromatic polyester, polyethylene-2,5-furandicarboxylate (PEF), which is an emerging, bioderived PET replacement with improved barrier properties. In contrast, PETase does not degrade aliphatic polyesters, suggesting that it is generally an aromatic polyesterase. These findings suggest that additional protein engineering to increase PETase performance is realistic and highlight the need for further developments of structure/activity relationships for biodegradation of synthetic polyesters.
Acromegaly with normal growth-hormone levels and pituitary histology (1979)

In rare cases, acromegalic patients have normal basal concentrations of growth hormone, and their acromegaly results from abnormal growth-hormone secretory patterns. A patient is reported with the clinical features of acromegaly, who had elevated somatomedin levels and an enlarged sella turcica, but whose serum growth-hormone levels on continuous monitoring were in the normal range, with levels of 2.8 to 8.9 ng/ml. Dynamic studies of growth hormone revealed normal responses to hypo- and hyperglycemia, but abnormal responses to L-dopa and thyroid-releasing hormone. At surgery, neither a pituitary adenoma nor eosinophilic hyperplasia was present. It is likely that this patient's acromegaly resulted from the presence of chronically high normal levels of growth hormone.
Recent applications of bifunctional trityl groups (2003)

Triphenylmethyl derivatives represent an important class of dyestuffs as well as a useful family of protecting groups widely used in organic synthesis to transiently block various functional moieties. These applications are well documented and have been a subject of a number of reviews. Here we focus instead on some novel applications of a trityl which make good use of its ability to easily form a stabilised cation in combination with additional peripheral functionalities. Topics covered include applications in bioconjugation, cross-linking, mass-spectrometry, fluorescence and optics.
A Highly Efficient, Stable, and Rapid Approach For Ex Vivo Human Liver Gene Therapy Via A Flap Lentiviral Vector (2003)

Allogenic hepatocyte transplantation or autologous transplantation of genetically modified hepatocytes has been used successfully to correct congenital or acquired liver diseases and can be considered as an alternative to orthotopic liver transplantation. However, hepatocytes are neither easily maintained in culture nor efficiently genetically modified and are very sensitive to dissociation before their reimplantation into the recipient. These difficulties have greatly limited the use of an ex vivo approach in clinical trials. In the present study, we have shown that primary human and rat hepatocytes can be efficiently transduced with a FLAP lentiviral vector without the need for plating and culture. Efficient transduction of nonadherent primary hepatocytes was achieved with a short period of contact with vector particles, without modifying hepatocyte viability, and using reduced amounts of vector. We also showed that the presence of the DNA FLAP in the vector construct was essential to reach high levels of transduction. Moreover, transplanted into uPA/SCID mouse liver, lentivirally transduced primary human hepatocytes extensively repopulated their liver and maintained a differentiated and functional phenotype as assessed by the stable detection of human albumin and antitrypsin in the serum of the animals for months. In conclusion, the use of FLAP lentiviral vectors allows, in a short period of time, a high transduction efficiency of human functional and reimplantable hepatocytes. This work therefore opens new perspectives for the development of human clinical trials based on liver-directed ex vivo gene therapy.
The three-dimensional relationship between acetabular rim morphology and the severity of femoral cam lesions (2013)

We examined the relationship between the size of the femoral cam in femoroacetabular impingement (FAI) and acetabular pathomorphology to establish if pincer impingement exists in patients with a femoral cam. CT scans of 37 symptomatic impinging hips with a femoral cam were analysed in a three-dimensional study and were compared with 34 normal hips. The inclination and version of the acetabulum as well as the acetabular rim angle and the bony acetabular coverage were calculated. These measurements were correlated with the size and shape of the femoral cams. While the size of the femoral cam varied characteristically, the acetabular morphology of the two groups was similar in terms of version (normal mean 23° (sd 7°); cam mean 22° (sd 9°)), inclination (normal mean 57° (sd 5°); cam mean 56° (sd 5°)), acetabular coverage (normal mean 41% (sd 5%); cam mean 42% (sd 4%)) and the mean acetabular rim angle (normal mean 82° (sd 5°); cam mean 83° (sd 4°)). We found no correlation between acetabular morphology and the severity of cam lesion and no evidence of either global or focal over-coverage to support the diagnosis of 'mixed' FAI. The femoral cam may provoke edge loading but removal of any acetabular bearing surface when treating cam FAI might induce accelerated wear.
Microbial Diversity Analysis in the Oxygen Minimum Zones of the Arabian Sea using Metagenomics Approach (2020)

Large oxygen-depleted areas known as oxygen minimum zones (OMZs) have been reported from the Arabian Sea, and recent reports indicate that these areas are expanding at an alarming rate. In marine waters, oxygen depletion may also be related to global warming and temperature rise. The acidification and deoxygenation due to OMZs can lead to major consequences wherein the plants, fish and other biota will struggle to survive in the ecosystem. The present study has identified the microbial community structure using next generation sequencing-based metagenomics analysis in water samples collected at different depths from the OMZs and non-OMZs of the Arabian Sea. Environmental variables such as depth, site of collection and oxygen concentration might influence species richness and evenness among microbial communities in these locations. Our observations suggest that population dynamics of microbes consisting of nitrate reducers accompanied by sulphate reducers and sulphur oxidizers influences the interconnected geochemical cycles of OMZs. In addition to providing baseline data related to the diversity and microbial community dynamics in waters in the OMZs; such analysis can provide insight into processes regulating productivity and ecological community structure of the ocean.