gebhart/patrepeval huggingface dataset:
Evaluation of intravitreal topotecan dose levels, toxicity and efficacy for retinoblastoma vitreous seeds: a preclinical and clinical study (2021)

Taken together, these experiments suggest that intravitreal topotecan monotherapy for the treatment of RB vitreous seeds is non-toxic and effective.
Halitosis in Children Undergoing Full Mouth Rehabilitation under General Anesthesia (2021)

Interventions and management modalities of pediatric halitosis have been suggested in the literature, however, the effect of full mouth rehabilitation (FMR) under general anesthesia (GA) on pediatric halitosis was not reported. Therefore, the present study was conducted to investigate parents' perceptions of their child's halitosis before and after FMR under GA; and to evaluate the effect of FMR on clinical halitosis. Fifty-seven children between 3-8 years old, scheduled for FMR under GA, were included after satisfying the inclusion criteria and upon parental consent. Parents' perception of halitosis in their children was evaluated using a standardized questionnaire and a breath sample was collected to assess the level of volatile sulfur compounds (VSCs) using OralChroma<sup>TM</sup> before and after FMR under GA. Sixty percent (<i>n</i> = 34) of the parents perceived halitosis in their children before FMR and about 80% (<i>n</i> = 27) of them reported improvement in halitosis after FMR. Clinical halitosis was detected in 84.2% (<i>n</i> = 48) of the sample before treatment. A statistically significant reduction in halitosis was found in 56.3% (<i>n</i> = 27) of the children after treatment (<i>p</i> < 0.001). In conclusion, majority of parents perceived an absence or reduction of halitosis in their children following FMR and significant improvement of clinical halitosis.
In Pursuit of the Parietal Cell – An Evolution of Scientific Methodology and Techniques (2019)

The stomach has unique embryologic and anatomic properties, making the study of the parietal cell technically challenging. Numerous individuals have devoted decades of research to unraveling the pathophysiological basis of this cell type. Here, we perform a scoping review of novel <i>in vitro</i> and <i>in vivo</i> methodology pertaining to the parietal cell. First, we evaluate early <i>in vitro</i> methods of parietal cell analysis. This section focuses on three major techniques: gastric gland isolation, parietal cell isolation, and parietal cell culture. We also discuss parietal cell physiology and pathophysiology. Second, we discuss more contemporary efforts involving confocal microscopy and gastric organoids, a new technique that holds much promise in unveiling the temporal-spatial dynamics of the cell. Finally, we will discuss findings from our laboratory where we identified an active gastric vacuolar H<sup>+</sup>-ATPase as a putative mechanism for refractory GERD. Overall, this review aims to highlight the major milestones in understanding an elusive yet important cell. Though in no way comprehensive, we hope to provide a birds-eye view to the study of this unique cell type in the gastrointestinal tract.
Carrier transport and device applications of the organic semiconductor based on liquid crystalline non-peripheral octaalkyl phthalocyanine (2018)

The molecular packing and electronic transport characteristics of mesogenic phthalocyanines having alkyl side chains at non-peripheral sites, 1,4,8,11,15,18,22,25-octaalkylphthalocyanine and its families, are described. These compounds exhibit very high long-range drift mobility up to 1.4 cm2/Vs evaluated by time of flight measurement and must be a candidate of organic semiconductor for printable electronics. We also describe possibilities of application to electronic devices such as solar cells and transistors. In addition, we report on a method for fabricating a highly oriented organic semiconductor thin film utilising latent mesogenic characteristics of the molecules.
Single and double layer windings in fractional slot-per-pole PM machines - effects on motor performance (2008)

This paper discusses the effects of fractional slots per pole in brushless permanent magnet motors. Example machines with 12, 16 and 20 pole are used to highlight their operation when using fractional slot windings and the performance is investigated in terms of winding MMF harmonic and torque production. 2D finite element analysis is used to simulate the machines in order to carry out the study. Torque ripple, cogging torque and back-EMF waveforms are all assessed for the example machines. The variation in the torque-speed operating areas is investigated to assess the operating ranges of the different arrangements.
Characterization of the carbon coating onto LiFePO4 particles used in lithium batteries (2006)

International audience
Near-PHz-bandwidth, phase-stable continua generated from a Yb:YAG thin-disk amplifier (2016)

We report on the generation of a multi-octave, phase-stable continuum from the output of a Yb:YAG regenerative amplifier delivering 1-ps pulses with randomly varying carrier-envelope phase (CEP). The intrinsically CEP-stable spectral continuum spans from 450 nm to beyond 2500 nm, covering a spectral range of about 0.6 PHz. The generated coherent broadband light carries an energy of 4 μJ, which can be scaled to higher values if required. The system has been designed and is ideally suited for seeding broadband parametric amplifiers and multichannel synthesizers pumped by picosecond Yb:YAG amplifiers, obviating the need for active timing synchronization required in previous approaches. The presented concept paves the way to cost-effective, reliable all-Yb:YAG single-cycle sources with terawatt peak-power and tens-of-Watts average power.
Influence of Halide Anions Cl–, Br–, and I– on the Zeta Potential of Oil-Wet Carbonate Surfaces (2019)

The benefits of injecting dynamic water (fluids with designed ionic composition) in carbonate reservoirs have been confirmed in various studies. The underlying mechanisms, however, resulting in enhanced oil recovery, are still not fully understood, which complicates the design of new efficient dynamic water formulations. In the current work, we study the effect of Arabian Gulf seawater and the addition of halide anions (Cl–, Br–, and I–) on carbonate surface alteration. Calcite and carbonate outcrop surfaces were aged with model oils (containing asphaltene, stearic acid, or a mixture of both) to render the rock more oil-wet and afterward conditioned in different dynamic water formulations. The surface charges at different treatment stages were investigated by zeta potential measurements to identify which dynamic water is most effective in altering the aged surfaces back to a more water-wet condition, which is believed to be more beneficial for enhanced oil recovery. Aging in model oils led to an increase in the magnitude of the negative zeta potential values on calcite and carbonate surfaces, indicating the adsorption of surface-active components of the model oils onto the rock surface. When conditioned afterward in the Arabian Gulf seawater with added halide ions, systematic changes of the zeta potential values were observed for the rock surfaces. The iodide system showed the strongest effect among the tested halides in terms of surface charge alteration, which is in line with the Hofmeister theory. Larger, more polarizable ions with low charge density (the chaotropic ions) seem more effective in removing adsorbed surface-active species from the rock surface. Based on these current results, it is highly recommended to use additional iodide in seawater flooding procedures to enhance the oil recovery from carbonate formations.
60.2: Invited Paper: New Technologies for Large‐Sized High‐Quality LCD TV (2005)

Abstract We propose a novel impulse driving method for the liquid crystal display, which improves motion picture quality without sacrificing maximum brightness. Moreover, we also propose new evaluation method for flat panel display in the bright environment, which reflect the display quality in the actual light situation.
Phosphorylation of Jak2 on Ser 523 InhibitsJak2-Dependent Leptin ReceptorSignaling (2006)

The leptin receptor, LRb, and other cytokine receptors are devoid of intrinsic enzymatic activity and rely upon the activity of constitutively associated Jak family tyrosine kinases to mediate intracellular signaling. In order to clarify mechanisms by which Jak2, the cognate LRb-associated Jak kinase, is regulated and mediates downstream signaling, we employed tandem mass spectroscopic analysis to identify phosphorylation sites on Jak2. We identified Ser(523) as the first-described site of Jak2 serine phosphorylation and demonstrated that this site is phosphorylated on Jak2 from intact cells and mouse spleen. Ser(523) was highly phosphorylated in HEK293 cells independently of LRb-Jak2 activation, suggesting a potential role for the phosphorylation of Ser(523) in the regulation of LRb by other pathways. Indeed, mutation of Ser(523) sensitized and prolonged signaling by Jak2 following activation by the intracellular domain of LRb. The effect of Ser(523) on Jak2 function was independent of Tyr(570)-mediated inhibition. Thus, the phosphorylation of Jak2 on Ser(523) inhibits Jak2 activity and represents a novel mechanism for the regulation of Jak2-dependent cytokine signaling.
HORIZONTAL SCROLL COMPRESSOR FOR TRANSPORT APPLICATIONS (2006)

With the need for increasing vehicle efficiency, reliability and refrigerant containment, vehicle manufactures are considering electric powered accessories as a replacement for current engine driven components.Electric hermetic and semi-hermetic air conditioning and refrigeration compressors are well suited for this application by providing the potential for both improved efficiency and capacity control along with the long life required by many transport applications.To meet the needs of this demanding application, a horizontal hermetic scroll compressor has been developed and tested over a broad range of operating conditions and speeds.The compressor design detailed in this paper utilizes a brushless permanent magnet (BPM) motor to provide high motor efficiency over a broad speed range while significantly reducing the size and weight of the motor.In addition the design utilizes many of the same components as a vertical scroll compressor but combines a suction gas cooled motor with a high-pressure oil sump.A mathematical model is presented for estimating the effect of high-to-low oil flow on compressor performance versus size, speed and operating condition.Volumetric efficiency is compared with a comparable high performance vertical scroll compressor.
Orthogonal Direct Sum Masking: A Smartcard Friendly Computation Paradigm in a Code, with Builtin Protection against Side-Channel and Fault Attacks. (2014)

Abstract. Secure elements, such as smartcards or trusted platform mod-ules (TPMs), must be protected against implementation-level attacks. Those include side-channel and fault injection attacks. We introduce ODSM, Orthogonal Direct Sum Masking, a new computation paradigm that achieves protection against those two kinds of attacks. A large vec-tor space is structured as two supplementary orthogonal subspaces. One subspace (called a code C) is used for the functional computation, while the second subspace carries random numbers. As the random numbers are entangled with the sensitive data, ODSM ensures a protection against (monovariate) side-channel attacks. The random numbers can be checked either occasionally, or globally, thereby ensuring a fine or coarse detec-tion capability. The security level can be formally detailed: it is proved that monovariate side-channel attacks of order up to dC − 1, where dC is the minimal distance of C, are impossible, and that any fault of Ham-ming weight strictly less than dC is detected. A complete instantiation of ODSM is given for AES. In this case, all monovariate side-channel at-tacks of order strictly less than 5 are impossible, and all fault injections perturbing strictly less than 5 bits are detected.
High-Pressure Study of the First-Order Phase Transition in MnAs (1967)

The first-order magnetic-transition temperature in MnAs has been measured as a function of both increasing and decreasing pressure. A critical pressure ${P}_{c}\ensuremath{\sim}4.6$ kbar has been obtained for the range of stability of the hexagonal phase. The pressure hysteresis increases with decreasing temperatures. Cooling to 77\ifmmode^\circ\else\textdegree\fi{}K under 5 kbar and then releasing pressure gives the $B31$ phase at atmospheric pressure, and it remains stable on heating to 138\ifmmode^\circ\else\textdegree\fi{}K, where there is an increase of magnetization of over a factor of 50. These data, together with earlier magnetic measurements on the system $\mathrm{Mn}{\mathrm{As}}_{1\ensuremath{-}x}{\mathrm{P}}_{x}$, demonstrate that the origin of the first-order phase transition is a large exchange striction in the basal planes plus a volume-dependent Weiss molecular field and manganese moment. This volume dependence is due to electron rearrangements associated with a high-spin-to-low-spin transition. The sharpness of the high-spin-to-low-spin transition cannot be accounted for by variations in crystal-field splitting with volume. It is suggested that a bandwidth is increasing with decreasing volume through the maximum bandwidth for spontaneous band ferromagnetism. The critical band appears to consist of ${t}_{\ifmmode\pm\else\textpm\fi{}}$ orbitals, which are primarily influenced by the Mn-Mn interactions within basal planes.
Epitaxial Growth of CdTe by H2 Sputtering (1988)

CdTe films can be grown epitaxially on InSb(100) by chemical sputtering in H 2 . The crystalline quality of the epitaxial layers is improved when the substrate temperatures are in the range of 200 to 250°C at a high rf discharge power of 400 W. In channeling experiments employing Rutherford backscattering spectrometry, the χ min (aligned yield/random yield) in the film prepared at 270°C and 400 W is 9.5%. A lattice strain of 0.05% is obtained from the results of X-ray diffraction. These values show that the crystalline quality of the epitaxial film grown by H 2 sputtering is superior to the film grown by Ar sputtering.
Provably good max-min-m-neighbor-TSP-based subfield scheduling for electron-beam photomask fabrication (2015)

Electron beam lithography (EBL) has been used for high-resolution photomask fabrication; its successive heating process in a certain region, however, may cause critical dimension (CD) distortion. As a result, subfield scheduling which reorders a sequence of subfields in the writing process is desirable to avoid the heating problem and thus CD distortion. To consider longer-range heat dissipation, this paper models a subfield scheduling problem with blocked region consideration as a constrained max-min m-neighbor travelling salesman problem (called constrained m-nTSP). To solve the constrained m-nTSP which is NP-complete in general, we decompose a constrained m-nTSP into subproblems conforming to a special case with points on two parallel lines, solve each of them with a provably good linear-time approximation algorithm, and merge them into a complete scheduling solution. In particular, our algorithm can also minimize the distances between successive subfields to alleviate the throughput degradation of EBL writing due to moving a writing head, while minimizing the heating problem. Average reductions of 10% in the maximum temperature and 14% in the distances between successive subfields over the state-of-the-art work can be achieved.
Advanced Mathematical Models As Simulated Traffic Data Collectors (2008)

This paper describes the use of a virtual traffic analysis sensor for integration into an existing sensor infrastructure. The ability to look up congestion information on the internet and using GPS navigation systems continues to enable commuters to plan more efficient routes and decrease their time on the roads. However, these systems are only as useful as the amount and accuracy of the data available for a region of interest. The authors describe a specific data collection monitor that is created by formulating mathematical models based on live traffic sensors. The proposed approach uses Radial Basis Functions (RBFs) as the primary mathematical model which uses a neural network algorithm to determine the optimized centers and parameters to yield the most accurate results. They present results from a trial on the I-25 corridor in Albuquerque, New Mexico. This technology complements existing vehicle sensors, including radar, microwave or video, resulting in an affordable solution to increasing data resolution and improving the accuracy of travel time predictions. The authors note that these virtual traffic monitor sensors also have the ability to calculate the predicted estimated variance (PEV) which allows a quantitative metric as to the quality of the data.
Unified generation model with donor and acceptor-type trap states for heavily doped silicon (2002)

A quasi-classical generation formulation is analytically developed for heavily doped silicon where electric field phenomena are important. This quasi-classical formalism is suitable for modeling thermal and electric field-dependent leakage mechanisms in semiconductor structures with multiple trap state types and populations. The formalism is valuable in the explanation of the heavily-doped gate-diode leakage characteristic in 4- to 64-Mb p/sup +/ substrate-plate-trench DRAM cells and p-channel MOSFETs. The development is implemented into a three-dimensional (3-D) finite-element device simulator (FIELDAY II), advancing VLSI device modeling.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Cross-Linkable Semi-Rigid 6FDA-Based Polyimide Hollow Fiber Membranes for Sour Natural Gas Purification (2019)

Robust high-performance hollow fiber membranes are needed for sour natural gas separation. In this study, a semi-rigid, cross-linkable, defect-free 6FDA-based polyimide hollow fiber membrane was developed and evaluated under pure H2S and three realistic sour natural gas feeds. No cross-linking-induced decline of H2S permeance was observed, indicating that the delicate asymmetric nanostructures of hollow fibers were well preserved during the cross-linking process due to the rigid molecular structure. For sour natural gas feed with low H2S concentration (0.5% H2S, 20% CO2, 79.5% CH4), the cross-linked hollow fiber membrane exhibited H2S permeance and H2S/CH4 permselectivity as high as 32 GPU and 30, respectively, at 450 psi and 35 °C. The CO2 permeance and CO2/CH4 permselectivity were also well maintained with values of 35 GPU and 32, respectively. Under more aggressive sour natural gas feeds (25% H2S, 5% CO2, 70% CH4 and 20% H2S, 20% CO2, 60% CH4), plasticization was observed for uncross-linked CF3 hollow fiber, but this phenomenon actually was beneficial for H2S separation. Specifically, H2S permeance and H2S/CH4 selectivity increased somewhat for the uncross-linked vs the cross-linked sample. In addition, the effects of sour gas composition on the performance of hollow fiber membranes were also considered. The results suggest increased H2S concentration in sour natural gas exhibits more pronounced effects on both H2S and CO2 permeance and selectivity than does increased CO2 concentration in the feed. Considering the impressive H2S and CO2 separation performance as well as the robustness of hollow fibers under highly aggressive sour natural gases, our work shows promising potential to simultaneously remove acid gases from sour natural gas with energy-efficient membrane processes under challenging feed conditions.
A Design Method of Logistics Support Simulation Support Software (2023)

In the process of system of systems simulation, logistics equipment support simulation is an important part. To meet the needs of logistics support simulation, this paper proposes a design method of logistics support simulation support software, and implements corresponding software based on this me
Plaunotol inhibits gastric cancer cells by induction of apoptosis (2005)

5903 BACKGROUND AND AIM: Plaunotol, a kind of isoprenoid, is an anti-gastric ulcer agent, available for clinical use since more than 20 years ago in Japan and Thailand. Some kinds of isoprenoids, such as docetaxel, paclitaxel, or geranylgeraniol, have been reported to have strong anti-cancer activities, but the effect of Plaunotol on cancer has not been evaluated. Here, we aimed to investigate the anti-tumor effect of Plaunotol on gastric cancer. METHODS: The gastric adenocarcinoma cell lines, namely MKN-45, and AZ-521, were used. Plaunotol was kindly gifted by Sankyo Co. Ltd., and tested at various concentrations (10, 20, 30 and 40 μmol/L). The proliferative activity of gastric cancer cells was assessed by the MTS assay. The annexin V / PI staining, and the TUNEL assay were used to analyze the induction of apoptosis. In addition, to clarify the mechanisms of the apoptosis induction, the activation of caspases-8, -9 and -3 was evaluated by flow-cytometry. RESULTS: Plaunotol treatment for 24h dose-dependently inhibited the proliferative activity of both gastric cancer cell lines tested. This inhibitory effect was dependent on induction of apoptosis, as confirmed by the annexin V / PI staining and the TUNEL assay. Both the caspase-8 and caspase-9 cascades were activated in the apoptosis induced by Plaunotol. CONCLUSION: Plaunotol dose-dependently inhibited the proliferative activity of gastric cancer cell lines, by induction of cell apoptosis. It should be a promising anti-gastric cancer agent, and since it is already available for clinical use in Japan and Thailand, and, in contrast to docetaxel and paclitaxel, which have strong side-effects, is proved to have little adverse effects, clinical trials should be started to confirm its properties in human beings.
Modelling of the electron field emission process in polycrystalline diamond-like carbon thin films (2002)

Diamond-like carbon (DLC) films are being researched as a possible cold cathode material to be used in large area flat panel displays. There are many models that attempt to account for the electron field emission process observed in these films. The initial models that were based to the fact that the emission was due purely to a negative electron affinity have now been modified. The emission from the DLC films, although following a Fowler-Nordheim type curve, do not give realistic values for the emission areas or barriers. Therefore, a model based on space charge band bending at the back junction was proposed to account for the electron emission at low electric fields from amorphous carbon (a-C). In this 'space charge interlayer' model the real cathode is the substrate, from which hot electrons are created due to the fully depleted diamond-like carbon film the electrons encounter before reaching the front surface of the film. The model based on this mechanism has already been published for nitrogenated amorphous carbon thin films. Here we extend the model to incorporate the emission of electrons from polycrystalline diamond thin films.