gebhart/patrepeval huggingface dataset:
Automotive EEPROM Qualification and Cost Optimization (2013)

This paper is about how an EEPROM characterization test program for the automotive market was developed for an initial IP Block, introduced into production and then cost and yield optimized for high volume production without risk to quality or reliability.
Optimized sensor placement for dependable roadside infrastructures (2019)

We present a multi-stage optimization method for efficient sensor deployment in traffic surveillance scenarios. Based on a genetic optimization scheme, our algorithm places an optimal number of roadside sensors to obtain full road coverage in the presence of obstacles and dynamic occlusions. The efficiency of the procedure is demonstrated for selected, realistic road sections. Our analysis helps to leverage the economic feasibility of distributed infrastructure sensor networks with high perception quality.
An Endovascular Approach to Cardioembolic Stroke Prevention in Atrial Fibrillation Patients (2003)

This report is of a 62-year-old woman presenting with a 3-year history of chronic atrial fibrillation (AF) and unable to tolerate chronic warfarin therapy due to bleeding episodes and unstable INR values. Additional high risk factors for stroke are a history of congestive heart failure and previous embolic stroke. Percutaneous left atrial appendage transcatheter occlusion (PLAATO ) was performed to seal the LAA. A transesophageal echocardiography (TEE) at the 1- and 6-month follow-up showed no device migration and no new thrombus related to the implant. The patient has been doing well on postprocedure aspirin with no embolic events.
Overcomplete Frame Thresholding for Acoustic Scene Analysis (2017)

In this work, we derive a generic overcomplete frame thresholding scheme based on risk minimization. Overcomplete frames being favored for analysis tasks such as classification, regression or anomaly detection, we provide a way to leverage those optimal representations in real-world applications through the use of thresholding. We validate the method on a large scale bird activity detection task via the scattering network architecture performed by means of continuous wavelets, known for being an adequate dictionary in audio environments.
NI-14 * THE DIFFUSION WEIGHTED IMAGING DERIVED INFLECTION B-VALUE AS A POTENTIAL MARKER FOR BRAIN TUMOR HETEROGENEITY (2014)

BACKGROUND: Diffusion-weighted MR (DWI) images are collected at different diffusion weightings (b-values) and the corresponding signal decreases as b-value increases. Typically, images are collected at two b-values to calculate an apparent diffusion coefficient (ADC). Calculating ADC in this way involves the underlying assumption that the diffusion-related signal decay is monoexponential. However, studies have shown this is often not the case at higher b-values (b > 1000 s/mm2). In this study, a biexponential model is used to model the DWI signal in a rat U87 brain tumor model. The inflection b-value (binf) is also introduced. This parameter is the b-value where the signal begins to deviate from monoexponential. METHODS: Eight male Athymic nude rats were inoculated with U87 brain tumor cells and imaged on day 18 post-inoculation without any treatment. Pre and post contrast T1-weighted images were collected. DWI images were acquired prior to contrast injection with b = 0,50,100,150,200,400,600,800,1000,2000,3000 s/mm2. Tumor ROIs were determined from the contrast-enhancing region on the T1 + C images. Contralateral normal ROIs were also drawn. The DWI signal was fit with a biexponential model: S/S0 = ffast*exp(-b*Dfast) + (1-ffast)*exp(-b*Dslow). The inflection b-value was computed as the minimum of the third derivative of the natural log of the biexponential fit. Biexponential parameters and binf were compared between tumor and normal tissue with a paired two-sample t-test. RESULTS: No differences were seen between tumor and normal tissue for any of the biexponential parameters. The inflection b-value (binf) was significantly lower in tumor compared to normal tissue (1920(160) vs. 3280(340) respectively, P = 0.008). CONCLUSIONS: The inflection b-value (i.e. the b-value where the DWI signal deviates from monoexponential) was lower in tumor tissue compared to normal tissue. Deviation from monoexponential behavior is thought to occur due to the presence of multiple diffusion pools and restrictions to water movement. Therefore, binf is a potential marker of tumor heterogeneity and/or invasion.
Supplementary Table 1 from DCDT2980S, an Anti-CD22-Monomethyl Auristatin E Antibody–Drug Conjugate, Is a Potential Treatment for Non-Hodgkin Lymphoma (2023)

&lt;p&gt;XLSX file - 30K, IC50 concentrations and CD22 expression levels for cell lines.&lt;/p&gt;
Amorphous diamond-Si semiconductor heterojunctions (1991)

Tetrahedrally co-ordinated amorphous carbon (amorphous diamond) deposited from the plasma stream of a vacuum arc on a graphite cathode is demonstrated as having semiconductor properties. The material is shown to form a heterojunction with both p- and n-type Si. A band gap of 2.9 eV is proposed for the a-diamond, based on the observed I-V characteristics of the heterojunction diodes. The material has a measured electrical breakdown strength of 109 V/m, which is comparable to that of high quality insulators such as SiO2 and Si3N4. Gas phase doping using B2H6, PH3, and N2 has been attempted.
New and Broader Applications of Anaerobic Digestion (1999)

Abstract The general performance of anaerobic digesters and the diversity of wastes that these can treat have been increasing steadily during the last decade as a result of new reactor designs, operating conditions, or the use of specialized microbial consortia. This article illustrates a few examples of new or broader applications of anaerobic digestion to the treatment of sewage, slurries, industrial wastewater, and solid wastes. In the case of domestic sewage, the sustainability of the overall process is much improved by the adoption of an anaerobic pretreatment step, for example, an upflow sludge blanket (USB) reactor. New methods for nutrient removal need to be coupled with anaerobic digestion. These may include, for example, anaerobic ammonium oxidation (anammox) and chemical P precipitation. In terms of industrial wastewaters, new additives are being developed that help the anaerobic sludge deal with unbalanced or toxic wastewaters. Engineering of anaerobic sludge granules is a new area of research that serves the purpose of expanding and rechanneling the catabolic capabilities of the sludge and of shortening the length of the adaptation period of the microbial consortia to xenobiotics. New biotechnologies are also being marketed for the anaerobic removal of sulfate and heavy metals in liquid and gaseous wastes. The new 'high-solids' fermentation technology used to treat solid wastes in industrialized regions is being expanded to suit specific needs of regions with other priorities such as the presence of nonbiocompatible solid wastes or the occurrence of fuel shortage. Keywords: anaerobic digestionUASBorganic wastessewagesulfate removalanammoxslurryindustrial wastewater.
Speciation and decomposition pathways of ruthenium catalysts used for selective C–H hydroxylation (2014)

Mechanistic insight into the C–H hydroxylation reaction catalysed by [(Me<sub>3</sub>tacn)RuCl<sub>3</sub>] has been obtained using desorption electrospray ionization mass spectrometry (DESI-MS) to identify reactive intermediates and to determine the fate of the starting metal complex.
Facile intramolecular coupling of alkyl and acyl ligands induced by Lewis acids: Mechanistic studies on the formation of zirconium ketone complexes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile intramolecular coupling of alkyl and acyl ligands induced by Lewis acids: Mechanistic studies on the formation of zirconium ketone complexesRobert M. Waymouth and Robert H. GrubbsCite this: Organometallics 1988, 7, 7, 1631–1635Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/om00097a028https://doi.org/10.1021/om00097a028research-articleACS PublicationsRequest reuse permissionsArticle Views142Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Demineralization and Remineralization Evaluation Techniques—Added Considerations (1992)

Methods used for the analysis of tooth de- and remineralization include techniques with various degrees of sophistication and quantitative capabilities, ranging from direct measures of mineral gain/loss (e.g., microradiography) to indirect measures (e.g., iodide permeability) of changes in tooth mineral properties. In all instances, the capabilities of methods for accurate determination of changes in tooth mineral properties are affected by procedures used in the preparation of specimens for analysis, the magnitude of change taking place in the test (vs. the detection limits of the techniques), and protocols for specimen analysis. In specific instances, such as in the case of dentin, unique specimen-handling and analysis procedures must be used to prevent artifacts. The choice of techniques for the assessment of de- and remineralization depends strongly upon study protocols and laboratory capabilities; however, 'quantitative' measures of mineral gain and loss are possible only if direct chemical or radiographic techniques are used. Either radiographic, cross-sectioned microhardness or polarized light can be used for the determination of lesion depth. Porosity, light-scattering, and surface microhardness are indirect techniques which complement direct measures of mineral gain and loss. Whatever methods are used in the analysis of de- and remineralization, researchers must take care to differentiate accurately among the quantitative capabilities of techniques used in analysis.
Compound FC-10696 Inhibits Egress and Spread of Marburg Virus (2021)

Abstract Marburg virus (MARV) VP40 protein (mVP40) directs egress and spread of MARV, in part, by recruiting specific host WW-domain containing proteins via its conserved PPxY Late (L) domain motif to facilitate efficient virus-cell separation. We reported previously that small molecule compounds targeting the viral PPxY/host WW-domain interaction inhibited VP40-mediated egress and spread. Here, we report on the antiviral potency of novel compound FC-10696, which emerged from extensive structure activity relationship (SAR) of a previously described series of PPxY inhibitors. We show that FC-10696 inhibits egress of both mVP40 VLPs and egress and spread of authentic MARV from HeLa cells and primary human macrophages. Moreover, FC-10696 treated mice displayed delayed onset of weight loss, clinical signs, and significantly lower viral loads compared to controls, with 14% of animals surviving 21 days following a lethal MARV challenge. Thus, FC-10696 represents a first-in-class, host-oriented inhibitor effectively targeting late stages of the MARV lifecycle.
Franco-Chinese Workshop : Collaboration in Photonics between University of Bordeaux and Huazhong University of Science and Technology (2016)

Workshop on the photonics in fields of terahertz, materials for optics, advance imaging.
Abstract A122: Case review for multi-targeted epigenetic therapy ( MTET) and its rationale in an integrative approach (2015)

Abstract In 2012 there were 11,957,599 advanced cancer cases in the US reported by CDC and the incidence has been almost unchanged over the previous 8 years (482,000 cases in 2000 versus 456,000 cases in 2008). There has been an annual percentage change of only (-0.6) between years 1999 to 2008 in cancer incidence. It is well described in the recent literature that epigenetic alterations are at least if not more important than genetic defects for the development and progression of malignant diseases. In the therapeutic field, transcriptional therapy is a very promising form of cancer treatment that is being extensively evaluated. It is speculated that inhibitors of DNA methylation and histone deacetylases can reactivate expression of tumor suppressor genes and induce histone hyperacetylation in the tumors of patients with solid cancers after treatment with these agents. Hypermethylation and transcription silencing of suppressor genes has been shown in 33% of breast cancers, 60% of prostate CA and 92% of colon CA. Although the value of such combination therapy both in chemoprevention, as well as treatment in patients with cancer is extremely important and can cause a significant shift in the current practice of oncology and cancer prevention, unfortunately, the results in clinical studies have been poor as the target histone hyperacetylation does not correlate with survival (possibly due to P 16/21 resistance, onco promoter mutations and unselectiveness of the therapies). To overcome such resistance we have developed a protocol using researched natural substances and off label drugs in a protocol called Multi targeted epigenetic therapy or MTET, currently tested in preclinical studies with promising results confirming apoptosis. This approach is shown to be clinically relevant in a set of cases treated and presented here. Here we present thirty cases of advanced resistant stage four disease that were treated through this method successfully with three samples cases to be described in details. We conclude that further research is warranted in a larger spectrum and in clinical trial setting to evaluate the efficacy of such method. Citation Format: Mohammad Nezami, Daniel Stobbe, Steven Hager. Case review for multi-targeted epigenetic therapy ( MTET) and its rationale in an integrative approach. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Innovations in Research and Treatment; May 18-21, 2014; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2015;75(13 Suppl):Abstract nr A122.
Evaluating the impact of treating the optimal subgroup (2017)

Suppose we have a binary treatment used to influence an outcome. Given data from an observational or controlled study, we wish to determine whether or not there exists some subset of observed covariates in which the treatment is more effective than the standard practice of no treatment. Furthermore, we wish to quantify the improvement in population mean outcome that will be seen if this subgroup receives treatment and the rest of the population remains untreated. We show that this problem is surprisingly challenging given how often it is an (at least implicit) study objective. Blindly applying standard techniques fails to yield any apparent asymptotic results, while using existing techniques to confront the non-regularity does not necessarily help at distributions where there is no treatment effect. Here, we describe an approach to estimate the impact of treating the subgroup which benefits from treatment that is valid in a nonparametric model and is able to deal with the case where there is no treatment effect. The approach is a slight modification of an approach that recently appeared in the individualized medicine literature.
Multiple modes of bed mass oscillation in gas-solids fluidized beds (1999)

The oscillation of gas-solids fluidized beds is a well investigated phenomenon. Knowledge of the amplitude and frequency of bed mass oscillations is necessary for the design of fluidized beds. Furthermore, these oscillations influence gas bubble behavior and, consequently, the overall chemical performance of the fluidized bed. The dynamics of a 0.80 cm ID gas-solids fluidized bed have been investigated by frequency analysis of measured in-bed pressure fluctuations. The peak frequency of the power spectral density is determined as a function of gas velocity (0--1 m/s), bed height (0.23--2.19 m), and measurement position (0.14--2.19 m, opposite positions). For a fixed experimental condition and fixed measurement position, multiple dominant peak frequencies are observed, corresponding to different modes of oscillation. The peak frequency is a weak function of gas velocity. The existence of multiple oscillation modes is not predicted by relationships presented in literature, which typically allow only a single natural frequency of fluidized bed oscillation. A previously derived relationship for the sloshing frequency of gas-liquid fluidized beds adequately describes the gas-solids fluidized bed data presented in this paper and explains the existence of multiple, alternating oscillation modes occurring at fixed experimental conditions. The presence of different oscillatory motions for the fluidized bedmore » were confirmed by visual observation of the bed surface.« less
Remarkable optical induction in the reduction of .alpha.-oxo esters with B-(3-pinanyl)-9-borabicyclo[3.3.1]nonane. Synthesis of .alpha.-hydroxy esters of 100% optical purity (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRemarkable optical induction in the reduction of .alpha.-oxo esters with B-(3-pinanyl)-9-borabicyclo[3.3.1]nonane. Synthesis of .alpha.-hydroxy esters of 100% optical purityHerbert C. Brown, Ganesh G. Pai, and Prabhakar K. JadhavCite this: J. Am. Chem. Soc. 1984, 106, 5, 1531–1533Publication Date (Print):March 1, 1984Publication History Published online1 May 2002Published inissue 1 March 1984https://pubs.acs.org/doi/10.1021/ja00317a083https://doi.org/10.1021/ja00317a083research-articleACS PublicationsRequest reuse permissionsArticle Views335Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Novel Non-Uniform Frame Structure Model for Power System Disturbance Propagation Analysis (2021)

The disturbance propagation mechanism is crucial for the preventive, corrective, and in-extremis control of power grids. This paper proposes a novel non-uniform frame structure model for power system disturbance propagation analysis. A general state transition model of the power grid is derived from the electromechanical wave propagation process. This is further used together with the Gaussian function to derive the non-uniform heterogeneous inertial continuum model, where the non-uniform parameters of the inertia are estimated using the state transition model. The proposed non-uniform frame structure model can be integrated with the electromechanical wave equation to study the disturbance propagation process. These novel developments allow us to tackle the inertial loss and uniform homogenous assumption in existing models. Extensive comparison results carried out on both the chain grid and the IEEE 118-bus system demonstrate that the proposed model can achieve 5- and 3-times accuracy improvements of the state-of-the-art SHU-FSM and ISHU-FSM models, respectively.
Intense Superoxide Dismutase-1 Immunoreactivity in Intracytoplasmic Hyaline Inclusions of Familial Amyotrophic Lateral Sclerosis with Posterior Column Involvement (1996)

This report concerns retrospective immunohistochemical and immunoelectron microscopic studies on superoxide dismutase-1 (SOD1) in intracytoplasmic hyaline inclusions (IHIs) of the anterior horn cells of three patients with familial amyotrophic lateral sclerosis (ALS) with posterior column involvement. All of the patients were members of the American "C" family. Almost all of the IHIs, present in the soma and cordlike swollen neurites of some affected neurons of the three patients, were intensely stained by an antibody to human SOD1. By contrast, the cytoplasm of anterior horn cells of the ALS patients and of ten control individuals reacted only weakly with the antibody or not at all. Immunoelectron microscopy revealed that the granule-associated thick linear structures that composed the IHIs were intensely labeled by the antibody to SOD1. The IHIs were also positively stained by antibodies to ubiquitin and phosphorylated neurofilament protein, with the distribution of immunoreactivity resembling that seen with the anti-SOD1 antibody. The DNA analysis disclosed a single-site GCC to GTC substitution at codon 4 (Ala4 --> Val) in the SOD1 gene from the brain samples of the patients and from the peripheral blood of their family members. Our results suggest that SOD1 is a component of IHIs and may interact with Ubiquitin and neurofilament protein, and point to the possibility that the presence of intense SOD1 immunoreactivity in the IHIs may be of relevance in processes involving structurally altered SOD1 molecules encoded by the mutated gene.
The Relevance of Voice Quality Features in Speaker Independent Emotion Recognition (2007)

This paper investigates the classification of different emotional states using presodic and voice quality information. We want to exploit the usage of different phonation types within the production of emotions. Therefore, as features we use prosodic features, voice quality parameters, and different combinations of both types. We study how prosodic and voice quality features overlap or complement each other in the application of emotion recognition. The classification is speaker independent and uses a reduced subset of 8 features and a Bayesian classifier.