gebhart/patrepeval huggingface dataset:
Microbiome facilitated pest resistance: potential problems and uses (2017)

Microbiome organisms can degrade environmental xenobiotics including pesticides, conferring resistance to most types of pests. Some cases of pesticide resistance in insects, nematodes and weeds are now documented to be due to microbiome detoxification, and is a demonstrated possibility with rodents. Some cases of metabolic resistance may have been misattributed to pest metabolism, and not to organisms in the microbiome, because few researchers use axenic pests in studying pesticide metabolism. Instances of microbiomes evolving pesticide resistance contributing to resistance of their hosts may become more common due the erratic nature of climate change, as microbiome populations typically increase and evolve faster in stressful conditions. Conversely, microbiome organisms can be engineered to provide crops and beneficial insects with needed resistance to herbicides and insecticides, respectively, but there has not been sufficient efficacy to achieve commercial products useful at the field level, even with genetically engineered microbiome organisms. © 2017 Society of Chemical Industry.
Transcriptional Response to a Dauer-Inducing Ascaroside Cocktail in Late L1 in C. elegans (2021)

The dauer diapause stage in <i>C. elegans</i> is a non-feeding alternative to the L3 larval stage that is highly resistant to harsh environmental conditions. The decision to enter dauer is a two-step process. First, L1 larvae encounter adverse conditions such as lack of food or overcrowding and decide to enter the L2d rather than the L2 stage. Second, L2d worms that continue to experience disadvantageous conditions decide to enter dauer instead of L3. Here, we have used RNA-seq to characterize the transcriptional response to a cocktail of dauer-inducing ascaroside pheromones at the late L1 stage as worms enter the L2d phase. We find that, in response to ascarosides, <i>C. elegans</i> L1 larvae preparing to enter the L2d stage begin upregulating genes involved in stress response and downregulating genes associated with growth and metabolism.
Modeling growth kinetics of thin films made by atomic layer deposition in lateral high-aspect-ratio structures (2018)

The conformality of thin films grown by atomic layer deposition (ALD) is studied using all-silicon test structures with long narrow lateral channels. A diffusion model, developed in this work, is used for studying the propagation of ALD growth in narrow channels. The diffusion model takes into account the gas transportation at low pressures, the dynamic Langmuir adsorption model for the film growth and the effect of channel narrowing due to film growth. The film growth is calculated by solving the diffusion equation with surface reactions. An efficient analytic approximate solution of the diffusion equation is developed for fitting the model to the measured thickness profile. The fitting gives the equilibrium constant of adsorption and the sticking coefficient. This model and Gordon's plug flow model are compared. The simulations predict the experimental measurement results quite well for Al2O3 and TiO2 ALD processes.
Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis (2018)

Tumour necrosis factor (TNF) signalling is mediated via two receptors, TNF-receptor 1 (TNFR1) and TNF-receptor 2 (TNFR2), which work antithetically to balance CNS immune responses involved in autoimmune diseases such as multiple sclerosis. To determine the therapeutic potential of selectively inhibiting TNFR1 in mice with experimental autoimmune encephalomyelitis, we used chimeric human/mouse TNFR1 knock-in mice allowing the evaluation of antagonistic anti-human TNFR1 antibody efficacy. Treatment of mice after onset of disease with ATROSAB resulted in a robust amelioration of disease severity, correlating with reduced central nervous system immune cell infiltration. Long-term efficacy of treatment was achieved by treatment with the parental mouse anti-human TNFR1 antibody, H398, and extended by subsequent re-treatment of mice following relapse. Our data support the hypothesis that anti-TNFR1 therapy restricts immune cell infiltration across the blood-brain barrier through the down-regulation of TNF-induced adhesion molecules, rather than altering immune cell composition or activity. Collectively, we demonstrate the potential for anti-human TNFR1 therapies to effectively modulate immune responses in autoimmune disease.
Higher Systemic Exposure to Unbound Active Metabolites of Regorafenib Is Associated With Short Progression‐Free Survival in Colorectal Cancer Patients (2020)

Regorafenib treatment improves survival of patients with metastatic colorectal cancer, but it is also characterized by detrimental side effects that may require modified dosing or interval schedules. Regorafenib is metabolized by cytochrome P450 3A4 in the liver to its active metabolites, M-2 and M-5. We examined area under the unbound plasma concentration-time curve (AUCu) to these compounds to establish pharmacokinetic bases for individualized dosing strategies. The plasma protein binding of M-2 and M-5 was approximately 10-fold lower than that of regorafenib, whereas AUCu values for active metabolites on both days 1 and 15 were significantly higher than that of regorafenib. Patients with higher AUCu values of M-2 or M-5 on day 1 showed significantly shorter progression-free survival than others, likely due, at least in part, to treatment discontinuation as a result of adverse events, especially occurred during first cycle.
Models for multiparty engagement in open-world dialog (2009)

We present computational models that allow spoken dialog systems to handle multi-participant engagement in open, dynamic environments, where multiple people may enter and leave conversations, and interact with the system and with others in a natural manner. The models for managing the engagement process include components for (1) sensing the engagement state, actions and intentions of multiple agents in the scene, (2) making engagement decisions (i.e. whom to engage with, and when) and (3) rendering these decisions in a set of coordinated low-level behaviors in an embodied conversational agent. We review results from a study of interactions "in the wild" with a system that implements such a model.
Magnetoresistance of high mobility HgTe quantum dot films with controlled charging (2022)

The magnetoresistance of HgTe quantum dot films, exhibiting a well-defined 1S e state charging and a relatively high mobility (1–10 cm 2 V −1 s −1 ), is measured with controlled occupation of the first electronic state.
Applied Federated Learning: Improving Google Keyboard Query Suggestions (2018)

Federated learning is a distributed form of machine learning where both the training data and model training are decentralized. In this paper, we use federated learning in a commercial, global-scale setting to train, evaluate and deploy a model to improve virtual keyboard search suggestion quality without direct access to the underlying user data. We describe our observations in federated training, compare metrics to live deployments, and present resulting quality increases. In whole, we demonstrate how federated learning can be applied end-to-end to both improve user experiences and enhance user privacy.
On the implementation of a low-power IEEE 802.11a compliant Viterbi decoder (2006)

This article describes a standard cell based novel implementation of a low-power Viterbi decoder (VD) targeted for the IEEE 802.11a wireless LAN system. Multiple clock rates have been used to reduce the power consumption and the inherent bandwidth mismatch between the add-compare-select (ACS) and traceback operations. Aggressive clock gating and innovative circuit techniques reduce the power consumption further. The normalized cell area and dynamic power consumption of the designed VD are 5.9 mm/sup 2/ and 53 mW respectively. The normalized power dissipation of the VD is 0.66 mW/Mbps.
Identifying and targeting determinants of melanoma cellular invasion (2016)

Epithelial-to-mesenchymal transition is a critical process that increases the malignant potential of melanoma by facilitating invasion and dissemination of tumor cells. This study identified genes involved in the regulation of cellular invasion and evaluated whether they can be targeted to inhibit melanoma invasion. We identified Peroxidasin (PXDN), Netrin 4 (NTN4) and GLIS Family Zinc Finger 3 (GLIS3) genes consistently elevated in invasive mesenchymal-like melanoma cells. These genes and proteins were highly expressed in metastatic melanoma tumors, and gene silencing led to reduced melanoma invasion in vitro. Furthermore, migration of PXDN, NTN4 or GLIS3 siRNA transfected melanoma cells was inhibited following transplantation into the embryonic chicken neural tube compared to control siRNA transfected melanoma cells. Our study suggests that PXDN, NTN4 and GLIS3 play a functional role in promoting melanoma cellular invasion, and therapeutic approaches directed toward inhibiting the action of these proteins may reduce the incidence or progression of metastasis in melanoma patients.
REACTIVITY OF THE GERMANIUM SURFACE (2006)

■ Abstract With the rapidly changing materials needs of modern microelectronics, germanium provides an opportunity for future-generation devices. Controlling germanium interfaces will be essential for this purpose. We review germanium surface reactivity, beginning with a description of the most commonly used surfaces, Ge(100) and Ge(111). An analysis of oxide formation shows why the poor oxide properties have hindered practical use of germanium to date. This is followed by an examination of alternate means of surface passivation, with particular attention given to sulfide, chloride, and hydride termination. Specific tailoring of the interface properties is possible through organic functionalization. The few solution functionalization methods that have been studied are reviewed. Vacuum functionalization has been studied to a much greater extent, with dative bonding and cycloaddition reactions emerging as principle reaction mechanisms. These are reviewed through molecular reaction studies that demonstrate the versatility of the germanium surface.
A 1S Direct-Battery-Attach Buck Voltage Regulator With 5-Stack Thin-Gate 22-nm FinFET CMOS Featuring Active Voltage Balancing and Cascaded Self-Turn-ON Drivers (2021)

1S Li-Ion battery platforms have largely been adopting on-board voltage regulators (VRs) switching at a few MHz or lower for high efficiency. However, large currents on board traces eventually undermine the end-to-end efficiency, while large passives limit system miniaturization. By integrating the VR in the package, the trace loss can be saved and the VR can switch at higher frequency with a smaller inductor with the same power budget, reducing the power-delivery footprint significantly. In addition, a bulky high-voltage device can be replaced by a series of low-voltage, thin-gate devices, enabling efficient, high-frequency switching operations due to the superior device figure of merit. The proposed 5-stack, thin-gate power stage can deliver a peak efficiency of 89.2% for a 3.8 V into 1.8-V out, with <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$10\times $ </tex-math></inline-formula> higher power density (~15 A/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ), switching at up to <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$10\times $ </tex-math></inline-formula> higher frequency (40 MHz) using <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$4\times $ </tex-math></inline-formula> – <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$10\times $ </tex-math></inline-formula> lower inductance (10–100 nH) than state of the art. Cascaded self-timed drivers and soft-switching low-side drivers minimize complexity in driving ten individual power switches safely, over a wide 1S battery voltage range. The measurement shows that each device stays within a safe voltage range during on and off states, due to voltage-balancing controls and self-timed drivers.
Crossover From Deterministic to Stochastic Nature of Resistive-Switching Statistics in a Tantalum Oxide Thin Film (2018)

We study the voltage dependence of the SET time statistics of bipolar resistive switching in a tantalum oxide thin film. Weibull analysis reveals that the SET time statistics exhibit a crossover from deterministic to stochastic nature in a single cell as the amplitude of the applied voltage is lowered. While the Joule heating effect has a general contribution to the SET physics in both deterministic and stochastic cases, the magnitude of the positive feedback cycle of the Joule heating determines the statistical nature. Sufficient feedback effect under a voltage of large amplitude increases the SET probability with time, resulting in the SET time distribution with a deterministic nature. When amplitude of the applied voltage is small, on the other hand, the feedback effect is weak hence the SET process is controlled by randomness of the cell condition. In this case, the SET time is totally unpredictable hence its statistics has a stochastic nature. Since the crossover between the deterministic and stochastic regimes is found to occur based on the electric field rather than the current, we argue that it stems from a field-driven redox reaction at the tantalum oxide/tantalum interface.
Evidence for Fe(IV):O in the Molecular Mechanism of Action of the Trioxane Antimalarial Artemisinin (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvidence for Fe(IV):O in the Molecular Mechanism of Action of the Trioxane Antimalarial ArtemisininGary H. Posner, Jared N. Cumming, Poonsakdi Ploypradith, and Chang Ho OhCite this: J. Am. Chem. Soc. 1995, 117, 21, 5885–5886Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://doi.org/10.1021/ja00126a042RIGHTS & PERMISSIONSArticle Views616Altmetric-Citations137LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (322 KB) Get e-AlertsSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Retinal safety of near infrared radiation in photovoltaic restoration of sight (2015)

Photovoltaic restoration of sight requires intense near-infrared light to effectively stimulate retinal neurons. We assess the retinal safety of such radiation with and without the retinal implant. Retinal damage threshold was determined in pigmented rabbits exposed to 880nm laser radiation. The 50% probability (ED50) of retinal damage during 100s exposures with 1.2mm diameter beam occurred at 175mW, corresponding to a modeled temperature rise of 12.5°C. With the implant, the same temperature was reached at 78mW, close to the experimental ED50 of 71mW. In typical use conditions, the retinal temperature rise is not expected to exceed 0.43°C, well within the safety limits for chronic use.
Deficiency in the A-subunit of coagulation factor XIII: two novel point mutations demonstrate different effects on transcript levels (1994)

Congenital deficiency in coagulation factor XIII is a rare autosomal recessive bleeding disorder. Although the defect was characterized over 30 years ago, little is known about the molecular basis of the disorder. Here, we show two novel point mutations in the gene of the A- subunit of factor XIII in the genetically isolated population of Finland. All eight factor XIII-deficient families identified in Finland were studied. The exons of the gene of A-subunit were amplified individually by polymerase chain reaction and subsequently screened by single-strand conformation polymorphism. Sequence analysis of the abnormally migrating fragments showed two point mutations resulting in an amino acid alteration. A C-to-T transition at Arg-661 in exon XIV created a premature stop codon. This mutation was detected in six of the eight families, thus being the major alteration causing FXIII deficiency in Finland. In two of the six families, the patients were compound heterozygotes with the Arg-661-Stop mutation in one allele and either a T-to-C point mutation in exon VI or a thus far uncharacterized mutation in the other allele. The T-to-C transition in exon VI resulted in a substitution of threonine for methionine 242. The transition was found in one family only, where it was in the heterozygote form combined with the Arg-661-Stop mutation. To evaluate the consequences of these mutations, steady-state FXIII mRNA levels were quantitated by solid-phase minisequencing. In addition to the termination of translation 70 amino acids before the initial stop codon, the Arg-661- Stop mutation causes a 10- to 30-fold reduction in FXIII mRNA levels. This is also likely to result in a low translation level in the truncated polypeptide. In contrast, Met-242-Thr mutation does not seem to affect the level of mRNA. Here, the absence of a functional and immunodetectable protein is probably caused by an altered conformation of the mutant polypeptide, resulting in early degradation of the defective protein.
Induced expression of neurotrophins in transgenic mice overexpressing ornithine decarboxylase and overproducing putrescine (1996)

Transgenic mice overexpressing ornithine decarboxylase (ODC) were recently generated (Halmekytö et al.: Biochem Biophys Res Commun 180:262-267, 1991). The dramatic ODC overexpression resulted in a very high accumulation of the polyamine putrescine in the brain. As elevated polyamine levels in the brain are believed to be associated with neuronal damage, we studied whether enhanced putrescine accumulation in the brain of these mice affects the expression of neurotrophins and their high affinity receptors. Northern blot analysis indicated that mRNA levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3) were significantly elevated about 1.5-fold in the hippocampus of ODC transgenic mice as compared with control animals. The levels of BDNF, NGF and NT-3 mRNA were also elevated in the kidneys of the transgenic mice. In eight other tissues examined there were no significant differences. The expression pattern of BDNF mRNA and of trkB and trkC (high affinity receptors for BDNF and NT-3 respectively) immunoreactivity in the hippocampal formation did not reveal significant differences. The induction of the expression of neurotrophins could belong to neuroprotective measures triggered by ODC overexpression.
Extending the bandwidth of electromagnetic cloaks (2007)

Using the idea of a transformation medium, a cloak can be designed to make a domain invisible to one target frequency. We examine the possibility of extending the bandwidth of such a cloak. We find that causality requirements impose severe constraints on the system parameters of the transformation medium, and we show that a specific form of ``reduction'' can help us to create a cloak that offers a reduced cross section in a finite frequency range. We also give a simple inequality that limits the bandwidth of operation.
EXPERIMENT OF A REAL SCALE BUILDING AND ACTUAL OPERATIVE ENERGY PERFORMANCE OF REMOTE SAVING ENERGY CONTROL FOR GHP (2019)

The facilities at university are composed of various buildings and rooms, and the multi sprit type air conditioning system is mainly used as the cooling and heating equipment. In energy conservation measures with many buildings like university facilities, improvement of efficiency to existing air conditioning equipment becomes a big issue.
A simple and accurate complex image interpretation of vertical antennas present in contiguous dielectric half-spaces (1993)

An efficient technique is developed to solve the important problem of vertical antennas located above and penetrating the interface between contiguous dielectric half-spaces. It begins by deriving the spectral expressions of the vector and scalar potential Green functions in terms of the TM wave spectral transmission coefficient. The complex image technique is used to derive simple, accurate, and rapidly convergent expressions of the full-wave spatial Green functions. The spatial Green functions are used in the moment method to model vertical thin-wire antennas residing above the penetrating the interface separating the contiguous dielectric half-spaces with and without loss.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Towards a better understanding of synergistic enzyme effects during refining of cellulose fibers (2022)

Refining of cellulose fibers is essential for reaching desired paper properties, yet highly energy demanding. Enzymes like endoglucanases (e.g. EndoC) are increasingly used to reduce energy consumption during pulp refining. However, prediction of the enzyme effect is still a major concern, considering the high variety of commercially available enzyme formulations, containing a range of different enzymes. In this study, synergisms of xylanases and β-glucosidases in combination with endoglucanases purified from enzyme formulations were studied and related to their refining performance. Size exclusion chromatography with multi-angle laser light scattering (SEC-MALLS) of carboxymethylcellulose revealed that a narrow size distribution and a high reduction in molecular weight are beneficial characteristics for refining. SEC-MALLS of hardwood pulp resulted in pronounced formation of low molecular weight fractions (log MW 4.3) for most efficient refining enzymes. Application of enzyme formulations and combinations of endoglucanase EndoC with β-glucosidase or xylanase using Fourier-transform infrared spectroscopy (FTIR) revealed synergistic effects that promoted degradation of amorphous parts of cellulose. Laboratory refining trials on hardwood pulp confirmed the increase in degree of refining and tensile index after addition of xylanase and β-glucosidase. Surface plasmon resonance (SPR) analysis resulted in strong binding of endoglucanases to regenerated cellulose, which correlated to refining performance.