gebhart/patrepeval huggingface dataset:
283 Safety and efficacy signals in the complete phase I study of live biotherapeutic MRx0518 in combination with pembrolizumab in patients refractory to immune checkpoint inhibitors (ICIs) (2020)

<h3>Background</h3> MRx0518 is a novel, human gut microbiome-derived, single-strain, live biotherapeutic in clinical development for treatment of solid tumours. Preclinically, MRx0518 induced broad immunostimulatory activity and demonstrated anti-tumorigenic effects in a range of murine tumor models. MRx0518 increased CD4+ and CD8+ T cell and NK cell tumor infiltration and decreased Tregs. Activation of tumour TLR5 was observed and linked to the bacterial flagellin moiety, which was shown to strongly induce NFκB, cytokine responses and IFNγ+ CD4+ and CD8+ T cells. <h3>Methods</h3> Heavily pre-treated patients refractory to ICIs were enrolled from March 2019 to March 2020. Patients had experienced at least SD from previous ICI (monotherapy or combination) but eventually progressed as confirmed by two radiological scans ≥4 weeks apart in the absence of rapid clinical progression and within 12 weeks of last dose of ICI. Patients were treated with 1 capsule of MRx0518 (1 × 10<sup>10</sup> to 1 × 10<sup>11</sup> CFU) BID and pembrolizumab (200 mg every 3 weeks) for up to 35 cycles or disease progression. Tumour response was assessed every 9 weeks per RECIST 1.1. The primary objective was to evaluate safety of the combination by monitoring toxicities in the first cycle of treatment. Secondary objectives were to evaluate efficacy via ORR, DOR, DCR and PFS. <h3>Results</h3> In Part A, patients with mRCC (n=9) and mNSCLC (n=3) were recruited. At data cut-off (21 Aug 20), 5 patients remain on study treatment. 83% of patients were male and 17% were female. Median number of prior lines of therapy was 3. 10 patients received nivolumab previously (83%), one received avelumab (8%) and one received pembrolizumab and nivolumab (8%). 83% of patients had experienced SD as best response to prior ICI and 17% had PR as best response. Of 6 patients with available PD-L1 results, 5 had a positive CPS/TPS (≥1) and 1 negative (&lt;1). The combination shows a positive safety profile with no treatment-related SAEs or toxicity-related drug discontinuations. No increase in irAEs has been reported.On study treatment, 2 RCC patients and 1 NSCLC patient experienced a PR, with an additional 2 RCC patients experiencing durable SD (6 and 13 months), a protocol defined DCR of 42%. Median PFS is 2.14 months at data cut-off (table 1). <h3>Conclusions</h3> This data represents first-in-class proof of concept for a live biotherapeutic in an oncology setting. The combination was tolerable and there were preliminary signals of efficacy. Part B (phase II) in NSCLC, RCC and bladder cancer is ongoing. Trial Registration www.clinicaltrials.gov NCT03637803 <h3>Ethics Approval</h3> This study was approved by University of Texas MD Anderson’s Institutional Review Board; approval ref. 2018-0290
The Florida Image Slicer for Infrared Astrophysics and Cosmology (2007)

We report on the design, manufacture, and scientific performance of the Florida Image Slicer for Infrared Astrophysics and Cosmol- ogy (FISICA), a fully c...
Material Science of Polymers for Engineers (2012)

You have accessMaterials Science of Polymers for EngineersSep 2012Material Science of Polymers for EngineersTim A. Osswald, Georg MengesTim A. OsswaldSearch for more papers by this author, Georg MengesSearch for more papers by this authorhttps://doi.org/10.3139/9781569905241.fmSectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF ShareFacebookTwitterEmailLinkedIn next chapter FiguresReferencesRelatedDetails 2012Pages: I-XIXPrint ISBN: 978-1-56990-514-2eISBN: 978-1-56990-524-1 Copyright & Permissions© 2012 Carl Hanser Verlag GmbH & Co. KGPDF DownloadLoading ...
Spatially Oversampled Demultiplexing in mmWave LoS MIMO (2018)

The transceiver separations required for synthesizing full rank MIMO matrices in line of sight (LoS) geometries scale as the square root of the product of carrier wavelength and range. The wavelengths at millimeter (mm) wave carrier frequencies are small therefore enable LoS spatial multiplexing with practical node form factors at ranges of 10–100 m, depending on the carrier frequency. However, such LoS MIMO links become frequency selective even with small geometric mismatches. Exact channel inversion in an N x N MIMO system requires fractionally spaced equalization, which is practically infeasible when operating at the very high data rates (multiple Gbps) that we are interested in. In this paper, we investigate spatial oversampling (more receive antennas than transmitted data streams) with symbol rate sampling, introducing designed delay diversity across different receive antennas, as a means for removing error floors when linearly separating the spatially multiplexed streams. We study the tradeoff between the number of additional receive antennas and the complexity of temporal equalization, and argue that an attractive example architecture, compatible with form factor constraints, is one in which the number of receive antennas is double the number of transmitted data streams.
SU‐FF‐J‐48: Developing In‐Line KV Fluoroscopic Verification for 4D Adaptive Radiotherapy (2006)

Purpose: To develop a system for on‐line real‐time treatment verification for 4D‐ART using in‐line kV fluoroscopy that will be included in a new generation of accelerator. Method and Materials: We have developed a software tool, as a component of the 4D‐ART verification system, to register fluoroscopic with dynamic (time‐sequenced) DRR (DDRR) images. The fluoroscopic images are obtained using kV x‐rays in‐line with the treatment‐beam direction. The DDRR images (DRRs at different phases during respiratory cycle) are generated from 4DCT. The image registration of DDRR and fluoroscopy is based on pre‐defined structures or points of interest and needs to be performed on‐line in real time, allowing the treatment parameters to be modified in real time if a discrepancy is observed. To approve the principle, we have employed a simulator (Siemens/Mevasim) to acquire the fluoroscopic images. Both hardware and software tools were developed to synchronize the acquisition of fluoroscopy with respiratory signal using a pressure sensor (Anzai). This synchronization, in turn, harmonizes fluoroscopic images with DDRR. The verification system was tested on a motion phantom and on lung cancer cases. Results: The system developed can effectively register respiration‐synchronized fluoroscopic and DDRR images for both phantom and patient data. The registration is able to detect discrepancies between planning images (DDRR) and verification images (in‐line fluoroscopy) for a 4D‐ART delivery. The system is found to be effective for validating respiratory gating. Conclusion: We have developed a treatment verification system for 4D‐ART. The system, employing in‐line kV fluoroscopy, may be used for validating respiratory gating and for 4D‐ART with the new generation of image‐guided delivery machine capable of in‐line dynamic imaging. The system can be also potentially useful for 4D real‐time tumor tracking based on fluoroscopy. Conflict of Interest: This work is supported in part by Siemens OCS.
ChemInform Abstract: Synthesis of Ketones by Cyclization of Cyano and Acetylenic Radicals: Use of δ‐Hydroxy Nitriles and δ‐ or ε‐Hydroxy Acetylenes. (1984)

Abstract Aus dem Alkohol (Ia) wird das Thioimidazolid (Ib) hergestellt, das mit Triphenylzinnhydrid zu einer radikalischen Zwischenstufe führt, die mit hoher Ausbeute unter Cycloaddition zu (II) reagiert.
Energy and Traffic Aware Full-Duplex Communications for 5G Systems (2017)

In this paper, we consider the problem of resource allocation in a dense small-cell network. Each small-cell base station is powered by a renewable energy source and operates in the full-duplex mode. We account for the rate-dependent energy term for data decoding into the total energy consumption at the small-cell base station. Owing to this new energy term, the transmitter and receiver operations now draw the energy from a common source. For a new energy consumption model and high interference scenario, which arises due to full-duplex communications, we formulate an energy and load aware resource management optimization problem under the energy causality and total transmit power constraints of the small-cell base station and uplink user equipments. In particular, the problem minimizes the data queue length of each network user equipment by jointly designing the beamformers, power, and sub-carrier allocation and their scheduling. Owing to the non-convexity of the problem, a global solution is inefficient; thus, we opt for the successive parametric convex approximation method to obtain a sub-optimal solution. This method solves for the convex approximate of the non-convex problem in each iteration and leads to faster convergence. For practical implementation, we further develop a distributed algorithm by using the dual decomposition framework, which relies on limited exchange of information between the involved base stations. Numerical simulations compare the network scenario which accounts for uplink channel rate-dependent energy consumption with that which ignores it. Results advocate the need for redesigning of the resource allocation scheme. In addition, numerical simulations also validate the usefulness of full-duplex communications over the half-duplex communications in terms of minimizing the sum data queue length of the users.
Soft Magnetism, Magnetostriction, and Microwave Properties of Fe-Ga-C Alloy Films (2018)

A systematic investigation of the soft magnetism, the change of modulus of elasticity with magnetization (ΔE effect), magnetostriction, and microwave properties has been carried out on iron-gallium-carbon thin films over a wide carbon content range. The phase transformation of the Fe-Ga-C films from bcc polycrystalline to amorphous leads to excellent magnetic softness with a low coercivity of less than 1 Oe, high saturation magnetization, narrow ferromagnetic resonance linewidth at 10 GHz of 20 to 30 Oe, and an ultra-low Gilbert damping constant of 0.0027. A record high piezomagnetic coefficient of 9.71 ppm/Oe, high saturation magnetostriction constant of 81.2 ppm, and large ΔE effect of -120 GPa at 500 nm were achieved.
Achieving secure and scalable data access control in information-centric networking (2015)

Shifting from host-oriented to data-oriented, information-centric networking (ICN) adopts several key design principles, e.g., in-network caching, to cope with the tremendous internet growth. In the ICN setting, data to be distributed can be cached by ICN routers anywhere and accessed arbitrarily by customers without data publishers' permission, which imposes new challenges when achieving data access control: (i) security: How can data publishers protect data confidentiality (either data cached by ICN routers or data accessed by authorized users) even when an authorized user's decryption key was revoked or compromised, and (ii) scalability: How can data publishers leverage ICN's promising features and enforce access control without complicated key management or extensive communication. This paper addresses these challenges by using the new proposed dual-phase encryption that uniquely combines the ideas from one-time decryption key, proxy re-encryption and all-or-nothing transformation, while still being able to leverage ICN's features. Our analysis and performance show that our solution is highly efficient and provable secure under the existing security model.
Sparse Matrix Transform for Hyperspectral Image Processing (2011)

A variety of problems in remote sensing require that a covariance matrix be accurately estimated, often from a limited number of data samples. We investigate the utility of several variants of a recently introduced covariance estimator-the sparse matrix transform (SMT), a shrinkage-enhanced SMT, and a graph-constrained SMT-in the context of several of these problems. In addition to two more generic measures of quality based on likelihood and the Frobenius norm, we specifically consider weak signal detection, dimension reduction, anomaly detection, and anomalous change detection. The estimators are applied to several hyperspectral data sets, including some randomly rotated data, to elucidate the kinds of problems and the kinds of data for which SMT is well or poorly suited. The SMT is based on the product of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> pairwise coordinate (Givens) rotations, and we also introduce and compare two novel approaches for estimating the most effective choice for <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> .
Differentially Private Stochastic Linear Bandits: (Almost) for Free (2022)

In this paper, we propose differentially private algorithms for the problem of stochastic linear bandits in the central, local and shuffled models. In the central model, we achieve almost the same regret as the optimal non-private algorithms, which means we get privacy for free. In particular, we achieve a regret of $\tilde{O}(\sqrt{T}+\frac{1}ε)$ matching the known lower bound for private linear bandits, while the best previously known algorithm achieves $\tilde{O}(\frac{1}ε\sqrt{T})$. In the local case, we achieve a regret of $\tilde{O}(\frac{1}ε{\sqrt{T}})$ which matches the non-private regret for constant $ε$, but suffers a regret penalty when $ε$ is small. In the shuffled model, we also achieve regret of $\tilde{O}(\sqrt{T}+\frac{1}ε)$ %for small $ε$ as in the central case, while the best previously known algorithm suffers a regret of $\tilde{O}(\frac{1}ε{T^{3/5}})$. Our numerical evaluation validates our theoretical results.
Biodegradable microcapsules designed via ‘click’ chemistry (2007)

Dextrans modified with alkyne and azide groups through hydrolysable carbonate esters form degradable microcapsules after Cu(I) catalysed 'click' reaction between azides and alkynes yielding triazole cross-links.
Probing the Surface Glass Transition Temperature of Polymer Films via Organic Semiconductor Growth Mode, Microstructure, and Thin-Film Transistor Response (2009)

Organic semiconductor-based thin-film transistors (TFTs) have been extensively studied for organic electronics. In this study, we report on the influence of the polymer gate dielectric viscoelastic properties on overlying organic semiconductor film growth, film microstructure, and TFT response. From the knowledge that nanoscopically-confined thin polymer films exhibit glass-transition temperatures that deviate substantially from those of the corresponding bulk materials, we show here that pentacene (p-channel) and cyanoperylene (n-channel) films grown on polymeric gate dielectrics at temperatures well-below their bulk glass transition temperatures [T(g)(b)] exhibit morphological/microstructural transitions and dramatic OTFT performance discontinuities at well-defined temperatures [associated with a polymer "surface glass transition temperature," or T(g)(s)]. These transitions are characteristic of the particular polymer architecture and independent of film thickness or overall film cooperative chain dynamics. Our results demonstrate that TFT measurements represent a new and sensitive methodology to probe polymer surface viscoelastic properties.
Nanoscale Topography Characterization for Direct Bond Interconnect (2019)

Hybrid bonding achieves mechanical and electrical connection between device wafers or dies, by directly joining dielectric and metal surfaces to form an all-inorganic interface. This direct bond interconnect (DBI) technology enables very fine pitch interconnects for high bandwidth interfaces. DBI is currently used for mass production of image sensors and is actively investigated for NAND, DRAM and MEMS applications. Characterizing and controlling nanoscale topography are essential for this type of bonding. After chemical mechanical polishing (CMP), the dielectric surface (usually SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) should have high planarity and sub-nm roughness, and the metal surface (usually Cu) should be slightly recessed below the dielectric surface in general. Atomic force microscopy (AFM) is a critical technique required to monitor the CMP process module and ensure a robust manufacturing process. While AFM and related techniques have been known for decades, nanoscale or sub-nm scale characterization for DBI requires careful choice of the analysis configurations and parameters to avoid misinterpretation. Here we discuss key considerations for AFM analysis, extraordinary AFM artifacts in the relative heights of the Cu and SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> areas, and topographic characteristics of Cu/SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> surface for successful hybrid bonding. The force between an AFM tip and a sample should be sufficiently low for consistent roughness measurement but sufficiently high for minimizing the effects of surface contamination or artifacts. Proper data processing such as flattening should be done to make realistic images. Occasionally we observed artifacts that produced an incorrect Cu height, which could render an actually recessed Cu area as protruding. This artifact tends to occur more if the tip is not fresh or the tapping force is low. If a data image is unusually blurry and the oxide roughness is much smaller than usual, it may be a sign of this artifact. Replacing the tip or scanning in contact mode can usually demonstrate if there was an artifact. AFM analysis revealed that a curved SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> surface (oxide rounding) tends to occur in the vicinity of Cu interconnect areas. Optimized CMP conditions can reduce the size of seams and eliminate them.
Optimal, Nanodefect Configurations via Strain-Mediated Assembly for Optimized Vortex-Pinning in Superconducting Wires from 5K-77K (2017)

Engineered nanoscale defects within REBa2Cu3O7-δ based coated conductors are of great interest for enhancing vortex-pinning, especially in high-applied magnetic fields. We have conducted extensive research to optimize vortex-pinning and enhance Jc via controlled introduction of various types of nanoscale defects. This paper provides a summary on how density, morphology, and composition of these engineered nanoscale defects affects vortex-pinning in different field and angular regimes in the temperature regime of 5K-77K. It is shown that certain nanodefect configurations that provide the best performance at high-operating temperatures also result in the optimal properties with record values of the critical current density and the pinning force at low operating temperatures and high-applied magnetic fields.
Molecular recognition: Design and synthesis of artificial receptors employing directed hydrogen bonding interactions (1990)

ADVERTISEMENT RETURN TO ISSUEPREVReportNEXTMolecular recognition: Design and synthesis of artificial receptors employing directed hydrogen bonding interactionsAndrew D. Hamilton Cite this: J. Chem. Educ. 1990, 67, 10, 821Publication Date (Print):October 1, 1990Publication History Received3 August 2009Published online1 October 1990Published inissue 1 October 1990https://doi.org/10.1021/ed067p821RIGHTS & PERMISSIONSArticle Views842Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (5 MB) Get e-Alerts Get e-Alerts
Characterization and applications of silver nanoparticles-decorated electrospun nanofibers loaded with polyphenolic extract from rambutan (Nepelium lappaceum) (2020)

Rambutan ( Nephelium lappaceum ) is a traditional fruit originally from Asia and now widely available in Central America. The rind of rambutan is rich in antioxidants, especially polyphenols, which have natural antiinflammatory and antimicrobial properties. Rambutan polyphenolic extract (RPE) was encapsulated in multicomponent electrospun nanofiber (ESNF) templates. These nanofibers were decorated with silver nanoparticles (AgNPs) via in situ electrochemical reduction. The RPE-loaded and AgNPs-decorated ESNF (AgNPs/RPE-ESNF) were evaluated for their hydrophilic, antioxidant, and antimicrobial properties. Results indicate that the addition of RPE to synthetic polycaprolactone (PCL) ESNF improves hydrophilicity and cell attachment and proliferation in vitro. In addition, a synergistic antibacterial and cell proliferation effect between AgNPs and RPE was observed when they were combined in the multi-functionalized ESNF system. The effectiveness of AgNPs/RPE-PCL ESNF as an antioxidant and antibacterial matrix could potentially promote wound healing and also serve as a hybrid scaffold for tissue engineering.
Sparse Signal Recovery in the Presence of Intra-Vector and Inter-Vector Correlation (2012)

This work discusses the problem of sparse signal recovery when there is correlation among the values of non-zero entries. We examine intra-vector correlation in the context of the block sparse model and inter-vector correlation in the context of the multiple measurement vector model, as well as their combination. Algorithms based on the sparse Bayesian learning are presented and the benefits of incorporating correlation at the algorithm level are discussed. The impact of correlation on the limits of support recovery is also discussed highlighting the different impact intra-vector and inter-vector correlations have on such limits.
Decidability of second-order theories and automata on infinite trees. (1969)

Introduction. In this paper we solve the decision problem of a certain secondorder mathematical theory and apply it to obtain a large number of decidability results. The method of solution involves the development of a theory of automata on infinite trees-a chapter in combinatorial mathematics which may be of independent interest.
Influence of Homozygosity for Methionine at Codon 129 of the Human Prion Gene on the Onset of Neurological and Hepatic Symptoms in Wilson Disease (2006)

This study shows for the first time, to our knowledge, that the human PrP polymorphism M129V influences the onset of symptoms in patients with the copper storage disorder Wilson disease.