gebhart/patrepeval huggingface dataset:
Dopant profiles in silicon created by MeV hydrogen implantation: Influence of annealing parameters (2010)

Abstract Dopant profiles created by MeV proton implantation in float zone and Czochralski silicon are examined with spreading resistance probe measurements after annealing in the temperature range of 300–500 °C. For the description of the profile shape, two species are used, one being the implanted and mobile hydrogen and the other being an immobile irradiation induced point defect complex. The diffusion of the implanted hydrogen through the radiation damaged layer is found to be of great relevance for the resulting depth distribution of the hydrogen related donors. An effective diffusion coefficient is given for implantation into float zone silicon. Furthermore, the profile shape varies significantly with the annealing temperature. It is proposed that two donor species are generated which each exhibit a different thermal stability, and that these two species have individual depth distributions. Profiles created in Czochralski silicon seem to be additionally affected by an enhanced generation of oxygen thermal donor species. (© 2011 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Poecilia reticulata as a valuable biological indicator of endocrine disruption (2012)

Natural and man-made compounds that interfere with the endocrine system activity are termed endocrine disruptors (ED). Endocrine disruptors may induce either hormone agonist or hormone antagonist effects in human and wildlife by interference with the biosynthesis and biological action of endogenous hormones. The biological response of an organism exposed to an ED which is able to determine quantifiable alterations at the molecular, cellular or physiological level, represents a potential biomarker of exposure to ED. In vertebrates, the mechanisms and metabolic pathways modulated by hormones are genetically conserved. Therefore, endocrine disruption induced by a chemical compound in a taxon will, presumably, result in similar effects in other species. In view of the easy breeding and keeping facilities, their rapid reproduction rate, the short time interval between generations and their ecological relevance, a series of fish species are studied as biological indicators. Several toxicological tests are elaborated in these species, testing for endocrine-disrupting effects of chemical compounds. Some of these fish are members of the family Poeciliidae and particularly
Vision stéréoscopique par ordinateur pour la détection et le suivi de cibles pour une application automobile (2008)

The increasing complexity of the driving environment and the efforts<br />for improving safety in the roads, explain the interest car<br />manufacturers put on the development of automatic driver assistance<br />technology. Many vehicles available on the market are already equipped<br />with such systems. While we have become proficient in judging the<br />state of the vehicle (speed, position, etc.), judging the surrounding<br />environment remains a difficult task. Among all the sensors capable of<br />perceiving the complexity of an urban environment, stereo-vision<br />has interesting capabilities, a large spectrum of applications<br />(pedestrian detection, vehicle tracking, white-line detection, etc.)<br />and a competitive price. For these reasons, Renault aims to identify<br />and solve the problems related to the implementation of such a system<br />in a vehicle series. The first related issue concerns the<br />development of the stereo-system calibration. Indeed the capability of<br />the system to provide measurements depends on parameters being<br />properly estimated, even when the system undergoes extreme conditions<br />(high temperatures, shock, vibration ...). Therefore, we present an<br />evaluation methodology that measures the degradation of the system's<br />performance with respect to the calibration. The second problem deals<br />with the detection of obstacles. The method we propose uses the<br />properties of rectification in an original fashion, and segments the<br />scene in road and obstacles. The last issue relates to the calculation<br />of the obstacles' speed. A large majority of approaches in the<br />literature approximate the speed of an obstacle from its successive<br />positions. In this calculation, the accumulation of uncertainties<br />makes this estimate extremely noisy. Our approach effectively combines<br />the strengths of the stereo-vision and optical flows to directly<br />obtain a robust and precise measure of 3-D speed.
Supplementary Figure Legends 1-3 from Plasminogen Kringle 5 Induces Apoptosis of Brain Microvessel Endothelial Cells: Sensitization by Radiation and Requirement for GRP78 and LRP1 (2023)

Supplementary Figure Legends 1-3 from Plasminogen Kringle 5 Induces Apoptosis of Brain Microvessel Endothelial Cells: Sensitization by Radiation and Requirement for GRP78 and LRP1
MS-275, a class 1 histone deacetylase inhibitor augments glucagon-like peptide-1 receptor agonism to improve glycemic control and reduce obesity in diet-induced obese mice (2020)

Given its glycemic efficacy and ability to reduce the body weight, glucagon-like peptide 1 receptor (GLP-1R) agonism has emerged as a preferred treatment for diabetes associated with obesity. We here report that a small-molecule Class 1 histone deacetylase (HDAC) inhibitor Entinostat (MS-275) enhances GLP-1R agonism to potentiate glucose-stimulated insulin secretion and decrease body weight in diet-induced obese (DIO) mice. MS-275 is not an agonist or allosteric activator of GLP-1R but enhances the sustained receptor-mediated signaling through the modulation of the expression of proteins involved in the signaling pathway. MS-275 and liraglutide combined therapy improved fasting glycemia upon short-term treatment and a chronic administration causes a reduction of obesity in DIO mice. Overall, our results emphasize the therapeutic potential of MS-275 as an adjunct to GLP-1R therapy in the treatment of diabetes and obesity.
Interleukin-13 Inhibits Protein Kinase C-triggered Respiratory Burst in Human Monocytes (1995)

Interleukin-13 (IL-13), a novel cytokine produced by activated lymphocytes modulates some monocyte functions, but no data is available concerning the signal transduction pathway. We show here, the inhibitory effect of IL-13 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-triggered reactive oxygen intermediate production in human monocytes and the signals involved in this response. Our results show that IL-13 produces rapid and transient phosphoinositide hydrolysis and intracellular Ca2+ mobilization. Furthermore, IL-13 induces intracellular cAMP accumulation through inositol 1,4,5-trisphosphate-dependent Ca2+ mobilization. Metabolic inhibitors were used to relate the first steps in signaling pathways to the inhibitory effect of IL-13 on TPA-triggered reactive oxygen intermediate production. Indeed, inhibitors of phospholipase C (neomycin), intracellular Ca2+ mobilization (8-[N,N-diethylamino]-octyl 3,4,5-trimethoxybenzoate hydrochloride), adenylate cyclase (delta 9-tetrahydrocannabinol), and protein kinase A (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) impair the IL-13 inhibitory response. Altogether these observations indicate that modulatory effect of IL-13 on the TPA-induced oxidative burst is the result of the intracellular cAMP accumulation through an inositol 1,4,5-trisphosphate-induced Ca2+ mobilization-dependent pathway.
Novel Autonomous Underwater Vehicle Based Upon Jellyfish Locomotion (2007)

This paper describes the process of developing a novel biomimetic autonomous underwater vehicle (AUV) inspired by jellyfish locomotion. Our interest in an AUV that mimics jellyfish locomotion stems from the jellyfish’s simplistic and robust physiology and neurological makeup. Jellyfish swimming gates are controlled by a neural architecture consisting of an outer nerve ring and an inner nerve ring. The inner nerve ring is responsible for incorporating the sensory input from the outer ring and innervating the subumbrellar swimming muscles. Additionally, cells in the inner ring generate endogenous rhythms and act as pacemakers. The system of pacemakers generates the highly maneuverable swimming gates that can be observed in jellyfish; swimming vertically, turning and hovering. The swimming gates have been shown to correspond to the dynamics of the response of a system of coupled identical van der Pol oscillators. These oscillators are capable of creating in-phase, out-of-phase and “asymmetric” phase-locked dynamics that are plausibly related to the basic modes of jellyfish locomotion of coordinated bout swimming, hovering, and turning, respectively. In addition, the system of oscillators is fault tolerant; if the modeled system of oscillators is disrupted, analogous to sections of the jellyfish being damaged, the oscillators adjust and maintain effective swimming gates allowing the jellyfish to remain mobile. The simplicity and fault tolerance of the oscillatory system makes it an ideal model for a locomotion control system for an AUV. The objective of the Jellyfish AUV project is to emulate the locomotion and control mechanisms of the biological jellyfish to create a simple and robust AUV, which is both highly maneuverable and low in cost. The iterative design process that resulted in a working Jellyfish AUV is detailed in this paper. Numerous designs were created, exploring different combinations of actuator mechanisms, body types and control systems. Different actuators were evaluated for their ability to meet our design requirements. These actuators ranged from off the shelf servos to the more exotic shape memory alloys (SMAs) and ionic polymer metal composites (IPMCs.) By the completion of the prototyping phase of the Jellyfish AUV project we had created a low cost AUV using off the shelf components including, servos, linkages and a microprocessor based control system. The input to the servos was derived from a system of coupled oscillators which were tuned to mimic the observation jellyfish gates. In addition, using the Jellyfish AUV prototype, we showed that the identified servo input patterns roughly translate to swimming, hovering, and turning.
Enhanced Cellular Functions on Polycaprolactone Tissue Scaffolds by O2 Plasma Surface Modification (2011)

Abstract This paper reports a study of using an oxygen‐based plasma modification to alter physicochemical properties of three‐dimensional (3D) PCL scaffolds and to improve mouse osteoblast cells attachment, proliferation, and osteoblastic differentiation. Different plasma modification times (1, 3, and 5‐min) and their effects on surface physicochemical properties were measured by contact angle measurement, surface energy calculation (Owens–Wendth Method), surface chemistry (XPS), and the surface topography (AFM). The effect of oxygen‐based plasma modification on attachment, proliferation, and osteoblastic differentiation were examined by shear flow assay, alamarBlue assay, scanning electron microscopy (SEM), and osteoblastic differentiation markers. Results of the contact angle measurement, total solid surface energy, surface chemistry, and roughness revealed that oxygen‐based plasma modification increased surface hydrophilicity, total surface energy, total amount of oxygen containing groups, and the surface roughness. A positive effect of plasma modification on cell proliferation on 3D PCL scaffolds was observed at the osteoblastic differentiation stage which was evaluated by the alkaline phosphatase (ALP) activity, osteocalcin protein secretion, and calcium mineralization. The higher ALP activity and osteocalcin secretion were detected from the cells on 3‐min plasma modified PCL surface compared to unmodified samples. The calcium mineralization and SEM micrographs data also showed that there was a higher mineralized matrix deposition on 3‐min plasma modified PCL scaffolds compared to unmodified scaffolds. These results suggest that the 3‐min plasma modification can accelerate differentiation phase of osteoblast through improving cell–scaffold interaction. magnified image
Toward a protein profile of Escherichia coli : Comparison to its transcription profile (2003)

High-pressure liquid chromatography-tandem mass spectrometry was used to obtain a protein profile of Escherichia coli strain MG1655 grown in minimal medium with glycerol as the carbon source. By using cell lysate from only 3 x 108 cells, at least four different tryptic peptides were detected for each of 404 proteins in a short 4-h experiment. At least one peptide with a high reliability score was detected for 986 proteins. Because membrane proteins were underrepresented, a second experiment was performed with a preparation enriched in membranes. An additional 161 proteins were detected, of which from half to two-thirds were membrane proteins. Overall, 1,147 different E. coli proteins were identified, almost 4 times as many as had been identified previously by using other tools. The protein list was compared with the transcription profile obtained on Affymetrix GeneChips. Expression of 1,113 (97%) of the genes whose protein products were found was detected at the mRNA level. The arithmetic mean mRNA signal intensity for these genes was 3-fold higher than that for all 4,300 protein-coding genes of E. coli. Thus, GeneChip data confirmed the high reliability of the protein list, which contains about one-fourth of the proteins of E. coli. Detection of even those membrane proteins and proteins of undefined function that are encoded by the same operons (transcriptional units) encoding proteins on the list remained low.
Implementation and Experimental Results (2005)

This chapter contains sections titled: DSP and Its RF Interface to DRP Transmitter Core Implementation IC Chip Evaluation Board Measurement Equipment GFSK Transmitter Performance Synthesizer Performance Synthesizer Switching Transients DSP-Driven Modulation Performance Summary Summary
The Gauss-Tree: Efficient Object Identification in Databases of Probabilistic Feature Vectors (2006)

In applications of biometric databases the typical task is to identify individuals according to features which are not exactly known. Reasons for this inexactness are varying measuring techniques or environmental circumstances. Since these circumstances are not necessarily the same when determining the features for different individuals, the exactness might strongly vary between the individuals as well as between the features. To identify individuals, similarity search on feature vectors is applicable, but even the use of adaptable distance measures is not capable to handle objects having an individual level of exactness. Therefore, we develop a comprehensive probabilistic theory in which uncertain observations are modeled by probabilistic feature vectors (pfv), i.e. feature vectors where the conventional feature values are replaced by Gaussian probability distribution functions. Each feature value of each object is complemented by a variance value indicating its uncertainty. We define two types of identification queries, k-mostlikely identification and threshold identification. For efficient query processing, we propose a novel index structure, the Gauss-tree. Our experimental evaluation demonstrates that pfv stored in a Gauss-tree significantly improve the result quality compared to traditional feature vectors. Additionally, we show that the Gauss-tree significantly speeds up query times compared to competitive methods.
Different nucleosome spacing in transcribed and non-transcribed regions of the ribosomal RNA gene inTetrahymena thermophila (1983)

The chromatin structure of the palindromic macronuclear ribosomal RNA genes of Tetrahymena thermophila was probed with micrococcal nuclease. Independent of the state of transcriptional activity, the transcribed region had a shorter nucleosome repeat (184 +/- 3 base pairs) than the non-transcribed central spacer or bulk chromatin (both 200 base pairs). The transcribed region displayed an increased sensitivity to micrococcal nuclease in rapidly growing cells, which suggested an altered chromatin structure during transcription. At early stages of nuclease digestion, the central spacer appeared to be in a highly structured nucleosomal array. Based on the differences in nucleosome repeat distance and sensitivity to nuclease, we conclude that quite different chromatin structures are maintained in two adjacent regions of the Tetrahymena ribosomal RNA gene. The DNA of the non-transcribed terminal spacer was found to contain sequences which are highly susceptible to micrococcal nuclease, precluding any conclusions about nucleosome structure in this region.
Challenges to Effective Research in Acute Trauma Resuscitation (2010)

Selection of study endpoints is one of the most important decisions in the design of effective clinical trials. Late mortality (e.g., 28 days) is an unambiguous endpoint, accepted by regulatory agencies, but it is viewed as problematic among researchers in the study of resuscitation for acute trauma injury with hemorrhagic shock. In February 2008, physicians, ethicists, statisticians, and research scientists from the military, academia, industry, the Federal Drug Administration, and the National Heart Lung and Blood Institute gathered to discuss the obstacles confronting the trauma community in their efforts to improve patient outcomes. The primary meeting objective was to generate preliminary suggestions for a series of follow-up meetings that will develop consensus guidelines for the design of large multicenter clinical trials. Twenty short presentations and discussions, summarized here, outlined the group's concerns and suggestions. Successful and failed, completed or ongoing, clinical studies provided insight as to endpoints that may be of value for future trauma and shock studies. In addition to the importance of appropriate endpoints in study design, other related topics were discussed, including trauma epidemiology, patient enrollment and inclusion criteria, community consultation and the difficulty of obtaining informed consent in acute trauma research, and the inclusion of quality of life in composite endpoints. The consensus was that more discussion was needed and that consideration of new endpoints for clinical trials in emergency trauma research was a worthwhile and necessary goal.
Miniature detachable photonic turn connector for optical module interface (2011)

Miniature embedded parallel optic modules are newly available and currently being designed into system equipment solutions to address the expanding requirement for very dense I/O bandwidth. These embedded miniature parallel optic modules greatly improve component densities by significantly reducing the board level footprint requirements of traditional parallel optic modules such as SNAP12, POP4, QSFP and the recent CXP specification. Implementation of these small form factor modules facilitates the ability to pack more processing power onto the physical board, thereby conserving valuable space and power in data centers. These mid-board mounted miniature modules enable the use of high density optical connectors, such as 24 and 48-fiber MPO type connectors at the card edge. These high density optical connectors significantly improve the interconnection density and operational function at the card edge over traditional front panel mounted parallel optics. Fiber optic jumper cables are used to provide the optical interface between the miniature embedded parallel optic modules and the high density optical connector at the card edge. Application issues to this enhanced embedded parallel optic system exist when the optical interface into the module does not equally facilitate the system value achieved by the miniature module and high density card edge connector. To complement the benefits offered by implementation of a miniature optical module, an equally innovative and economical module connector interface is required. This module connector must enhance the functionality of providing the optical jumper interface between the module and high density connector at the card edge. The design solution presented herein is a low cost, low profile connector system that provides a reliable, consistent, and repeatable mating interface to the miniature optical module. It achieves the design and performance requirements needed to effectively implement these new high density parallel optic systems.
Method of drying passivated micromachines by dewetting from a liquid-based process (2023)

A method of fabricating a micromachine includes the step of constructing a low surface energy film on the micromachine. The micromachine is then rinsed with a rinse liquid that has a high surface energy, relative to the low surface energy film, to produce a contact angle of greater than 90.degree. between the low surface energy film and the rinse liquid. This relatively large contact angle causes any rinse liquid on the micromachine to be displaced from the micromachine when the micromachine is removed from the rinse liquid. In other words, the micromachine is dried by dewetting from a liquid-based process. Thus, a separate evaporative drying step is not required, as the micromachine is removed from the liquid-based process in a dry state. The relatively large contact angle also operates to prevent attractive capillary forces between micromachine components, thereby preventing contact and adhesion between adjacent microstructure surfaces. The low surface energy film may be constructed with a fluorinated self-assembled monolayer film. The processing of the invention avoids the use of environmentally harmful, health-hazardous chemicals.
Electronic and superconducting properties of theTi3P-type compoundsNb3As andNb3Si (1976)

Superconductivity has been observed below temperatures of about 0.3 K in the tetragonal ${\mathrm{Ti}}_{3}$P-type compounds ${\mathrm{Nb}}_{3}$Si and ${\mathrm{Nb}}_{3}$As. Measurements of the electrical resistivity, heat capacity, superconducting transition temperature, and the critical magnetic field curve are reported. From these measurements, values of the electronic specific-heart coefficient $\ensuremath{\gamma}$, the Debye temperature $\ensuremath{\Theta}$, the electron-phonon coupling constant $\ensuremath{\lambda}$, and the Ginzburg-Landau parameter $\ensuremath{\kappa}$, are deduced. Both compounds have low $\ensuremath{\gamma}$ values (${\ensuremath{\gamma}}_{{\mathrm{Nb}}_{3}\mathrm{Si}}\ensuremath{\approx}2.15$ mJ/${\mathrm{K}}^{2}$g-atom and ${\ensuremath{\gamma}}_{{\mathrm{Nb}}_{3}\mathrm{As}}\ensuremath{\approx}0.9$ mJ/${\mathrm{K}}^{2}$g-atom) which probably accounts for the low transition temperatures. A comparison of their electronic and superconducting properties with those of ${A}_{3}B$ compounds of the $A15$ type suggests that the electron-phonon interaction is quite large in these ${\mathrm{Ti}}_{3}$P-type materials.