gebhart/patrepeval huggingface dataset:
Nickel‐katalysierte Isomerisierung von Butadien‐Hydrazon‐Misch‐Oligomeren. Vorläufige Mitteilung (1978)

Nickel‐catalysed Isomerization of Unsaturated Azocompounds Unsaturated azocompounds, produced by the nickel‐catalysed reaction of butadiene with hydrazones, can be isomerized in presence of the same nickel catalyst. The influence of nickel concentration, temperature and structure of the azocompound on this rearrangement is described.
A patient‐friendly 16‐channel transmit/64‐channel receive coil array for combined head–neck MRI at 7 Tesla (2022)

This new head-neck array coil is the first demonstration of a device of this nature used for combined full-brain, head-neck, and cervical-spine imaging at 7 T. The array coil is well suited to provide large FOV images, which potentially improves ultrahigh field neuroimaging applications for clinical settings.
Thermal and Electrical Characterizations of Ultra-Thin Flexible 3YSZ Ceramic for Electronic Packaging Applications (2016)

Abstract This paper presents thermal and electrical characterizations of an ultra-thin flexible 3YSZ (3 mol% Yttria Stabilized Zirconia) ceramic substrate to explore its potential for electronic packaging applications. The thicknesses of the ultra-thin 3YSZ substrates were 20 μm and 40 μm. The flexible thin ceramic substrate can provide not only better modulus for higher robustness in manufacturing, especially in Z-axis direction of modules, but also low thermal resistance for high density 2D (two dimensional) / 3D (three dimensional) power module packaging applications. To better understand the thermal and electrical properties of the ultra-thin flexible ceramic, different measurements were employed. Thermal conductivity was measured at different temperatures by 3-omega method, the results were verified by thermo-reflectance measurement at room temperature. Relative permittivity was measured from 100 Hz to 10 MHz, with dielectric losses determined by dielectric spectroscopy. The dielectric breakdown of the ultra-thin flexible 3YSZ was measured, from room temperature to 150 °C. Weibull analysis was performed on 20 measurements for each temperature. The test results showed that the thermal conductivity of 3YSZ decreased from 3.3 W/mK at 235 K to 2.2 W/Mk at 600 K. The relative permittivity decreased from 30.9 to 27.3 for higher frequencies for both substrates with different thickness. The temperature-dependence of relative permittivity and dielectric loss was studied. The results showed that these two parameters increased slowly from −65 °C to 150 °C, but more repidly from 175 °C to 250 °C. The dielectric breakdown decreased at higher temperature, from 5.76 kV to 2.64 kV for thickness of 20 μm, 7.84 kV to 3.36 kV for thickness of 40 μm. SEM (Scanning Electron Microscopy), EDS (Energy-dispersive X-ray Spectroscopy) and XRD (X-ray Powder Diffraction) analysis was performed to compare the microstructure of 3YSZ ultra-thin substrate and that of AlN (Aluminum Nitride) substrate. The microstructure of 3YSZ consisted of smaller round particles and that of AlN contained larger columnar particles. FEA (Finite Element Analysis) simulations were also applied to demonstrate the thermal properties of 3YSZ in simplified model of power modules. Though the measurement results showed that it did not meet expectations for high temperature power modules, the present work showed potential applications of the ultra-thin 3YSZ substrates in low voltage power modules, LED modules.
Optimization of autoclave cycles and selection of formulation for parenteral products, Part III: Effect of formulation variables on sporicidal kinetics. (1984)

In optimizing the autoclave cycle of a parenteral product, sterilizing temperature and exposure time could both be reduced by enhancing the thermal lethality on bacterial spores through formulation changes. Consequently, less chemical degradation with an assurance of sterility could be expected. Citric acid (0.1 M, pH 2), disodium phosphate (0.1 M, pH 10), 50% propylene glycol and 50% polyethylene glycol 300 effectively enhanced the thermal lethality on Bacillus stearothermophilus spores. Sporicidal kinetic parameters were calculated by non-isothermal kinetic treatment.
Timeliness of Infectious Diseases Referral and Inappropriate Antibiotic Usage Post-Referral in an Asian Tertiary Hospital (2019)

Infectious diseases (ID) specialists advise on complicated infections and are advocates for the interventions of antibiotic stewardship programs (ASP). Early referral to ID specialists has been shown to improve patient outcomes; however, not all referrals to ID specialists are made in a timely fashion. A retrospective cross-sectional study of all referrals to ID specialists in a Singaporean tertiary hospital was conducted from January 2016 to January 2018. The following quality indicators were examined: early referral to ID specialists (within 48 h of admission) and ASP intervention for inappropriate antibiotic usage, even after referral to ID specialists. Chi-square was used for univariate analysis and logistic regression for multivariate analysis. A total of 6490 referrals over the 2-year period were analysed; of those, 36.7% (2384/6490) were from surgical disciplines, 47.0% (3050/6490) were from medical disciplines, 14.2% (922/6490) from haematology/oncology and 2.1% (134/6490) were made to the transplant ID service. Haematology/oncology patients and older patients (aged ≥ 60 years) had lower odds of early referral to ID specialists but higher odds of subsequent ASP intervention for inappropriate antibiotic usage, despite prior referral to an ID specialist. Elderly patients and haematology/oncology patients can be referred to ID specialists earlier and their antimicrobial regimens further optimised, perhaps by fostering closer cooperation between ID specialists and primary physicians.
Mapping the Dynamic Functions and Structural Features of AcrB Efflux Pump Transporter Using Accelerated Molecular Dynamics Simulations (2018)

Multidrug efflux pumps confer resistance to their bacterial hosts by pumping out a diverse range of compounds, including most antibiotics. Being more familiar with the details of functional dynamics and conformations of these types of pumps could help in discovering approaches to stop them functioning properly. Computational approaches, particularly conventional molecular dynamics simulations followed by diverse post simulation analysis, are powerful methods that help researchers by opening a new window to study phenomena that are not detectable in as much detail in vitro or in vivo as they are in silico. In this study, accelerated molecular dynamics simulations were applied to study the dynamics of AcrB efflux pump transporters in interaction with PAβN and tetracycline as an inhibitor and a substrate, respectively, to compare the differences in the dynamics and consequently the mechanism of action of the pump. The different dynamics for PAβN -bound form of AcrB compared to the TET-bound form is likely to affect the rotating mechanism typically observed for AcrB transporter. This shows the dynamics of the active AcrB transporter is different in a substrate-bound state compared to an inhibitor-bound state. This advances our knowledge and helps to unravel the mechanism of tripartite efflux pumps.
Is there a benefit to frozen section analysis at the time of partial nephrectomy? (2013)

In our institutional cohort, frozen section analysis failed to impact final margin status in patients with documented renal cell carcinoma. Given the oncologic uncertainty of positive surgical margins, further prospective evaluation is necessary to determine the clinical utility of frozen section analysis.
Discovery and Characterization of a Peptoid with Antifungal Activity against Cryptococcus neoformans (2016)

Studies show there is an increasing rate of fungal infections, especially in immunocompromised patients and treatments for fungal genera, such as <i>Aspergillus</i>, <i>Candida</i>, and <i>Cryptococcus</i>, carry significant cytotoxicity with an increasing prevalence of antifungal resistance. We have previously reported a high-throughput assay for identifying peptoids with antimicrobial properties from combinatorial libraries. Here we report the application of this assay in identifying a peptoid with antifungal properties against <i>Cryptococcus neoformans</i>. Termed AEC5, this peptoid has comparable potency to existing clinical antifungal agents, excellent stability, and minimal cytotoxicity in mammalian cells.
Solubility and Solvation in Ionic Liquids (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
PROBA-V, a vegetation satellite (2010)

The SPOT/VEGETATION mission is going to its end and ESA, CNES and industry investigated the possibility of proposing a "VEGETATION like instrument" onboard a satellite based on the PROBA concept and design. The studies have demonstrated that due to the recent advances in miniaturization technology, this objective can be reached without losing compromising quality with respect to the SPOT/VEGETATION Instrument. The resulting PROBA-V mission aims at ensuring continuity to SPOT/VEGETATION products, providing daily images at low resolution over the world. The instrument consists of Three-Mirror-Anastigmatic (TMA) cameras (to cover the 2250 km swath width), each equipped with blue, red, near-infrared and short-wave infrared detectors. As a passive thermal control method is used, a thermo-elastic model is used in the user segment on-ground to correct for the geometric and radiometric properties. While for this ESA project, Verhaert Space is responsible as prime for the instrument, VITO acts as prime for setting up and running the user segment, including geometric and radiometric calibration. Special attention is placed to dealing with the different noise characteristics, viewing angles and ground sampling distance of the detectors. The Ground Segment and the User Segment will exploit the satellite capabilities, receiving, processing, archiving and disseminating Primary products, for advanced users and corrected Synthesis for the common Vegetation end users at 1000m and 250m spatial resolution. However, in the end a more agile, area and power efficient satellite system is designed that gives equal and in many parameters better performance than the current SPOT/VEGETATION Instruments.
Sentio: Distributed Sensor Virtualization for Mobile Apps (2018)

This paper presents Sentio, a distributed middle-ware designed to provide mobile apps with seamless connectivity to remote sensors when the sensing code and the sensors are not physically on the same device, e.g., when the sensing code is offloaded to the cloud. Sentio presents the apps with virtual sensors that are mapped to remote physical sensors. Virtual sensors can be composed into higher-level sensors, which fuse sensing data from multiple physical sensors. Furthermore, they are mapped to the best available physical sensors when the app starts and re-mapped transparently to other physical sensors at runtime in response to context changes. Sentio was designed to work without modifications to the operating system and to provide low-latency access to remote sensors, which is beneficial to apps with real time-requirements such as mobile games. We have built a prototype of Sentio on Android. We have also developed four apps based on Sentio to understand the programming effort and evaluate the performance. The development of the apps shows that complex sensing tasks can be implemented quickly, benefiting from Sentio's high-level API. The experimental results show that Sentio achieves good real-time performance.
Olfactory receptor signaling is regulated by the post‐synaptic density 95, Drosophila discs large, zona‐occludens 1 (PDZ) scaffold multi‐PDZ domain protein 1 (2009)

The unique ability of mammals to detect and discriminate between thousands of different odorant molecules is governed by the diverse array of olfactory receptors expressed by olfactory sensory neurons in the nasal epithelium. Olfactory receptors consist of seven transmembrane domain G protein-coupled receptors and comprise the largest gene superfamily in the mammalian genome. We found that approximately 30% of olfactory receptors possess a classical post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) domain binding motif in their C-termini. PDZ domains have been established as sites for protein-protein interaction and play a central role in organizing diverse cell signaling assemblies. In the present study, we show that multi-PDZ domain protein 1 (MUPP1) is expressed in the apical compartment of olfactory sensory neurons. Furthermore, on heterologous co-expression with olfactory sensory neurons, MUPP1 was shown to translocate to the plasma membrane. We found direct interaction of PDZ domains 1 + 2 of MUPP1 with the C-terminus of olfactory receptors in vitro. Moreover, the odorant-elicited calcium response of OR2AG1 showed a prolonged decay in MUPP1 small interfering RNA-treated cells. We have therefore elucidated the first building blocks of the putative 'olfactosome', brought together by the scaffolding protein MUPP1, a possible central nucleator of the olfactory response.
ChemInform Abstract: ORGANIC FLUORINE COMPOUNDS. 34. SOME REACTIONS OF VALENCE‐BOND ISOMERS OF TETRAKIS(TRIFLUOROMETHYL)PYRROLES (1980)

Abstract Aus dem Cyclopropenylketon (I) erhält man mit Anilin in Gegenwart von TiCl 4 z.B. das Imin (II).
Levels of the soluble forms of CD80, CD86, and CD83 are elevated in the synovial fluid of rheumatoid arthritis patients (2005)

The release of soluble forms of CD80 (sCD80), CD86 (sCD86), and CD83 (sCD83) provide a potentially powerful immunoregulatory mechanism. We therefore investigated the potential presence and relative levels of these molecules in the synovial fluid (SF) and serum of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Serum and SF levels were measured by enzyme-linked immunosorbent assay. Serum levels of sCD80, sCD86, and sCD83 in RA and OA patients were similar to those present in normal donor serum (NDS) and the SF of OA patients. In contrast, when compared with NDS and OA SF levels, almost all RA SF samples had elevated sCD83 levels (32/35, >0.63 ng/ml) and a substantial proportion had elevated sCD80 (13/29, >0.22 ng/ml) or sCD86 (16/33, >2.31 ng/ml) levels. Analysis of matched pairs of serum and SF from RA patients demonstrated that the SF/serum ratio for sCD80 (95% CI = 1.7-3), sCD86 (95% CI = 1.5-3.1), and sCD83 (95% CI = 3.6-7.8) levels was >1 in almost all patients. In conclusion, this study shows that the SF from almost all RA patients contain elevated levels of sCD83 and the majority of these samples also contain elevated levels of sCD80 and/or sCD86. These molecules may play a role in modulating immune responses within the rheumatoid joint.
Efficacy of a 4-Antigen Staphylococcus aureus Vaccine in Spinal Surgery: The STaphylococcus aureus suRgical Inpatient Vaccine Efficacy (STRIVE) Randomized Clinical Trial (2023)

In patients undergoing elective spinal fusion surgical procedures, SA4Ag was safe and well tolerated but, despite eliciting substantial antibody responses that blocked key S. aureus virulence mechanisms, was not efficacious in preventing S. aureus infection. Clinical Trials Registration. NCT02388165.
Normalized Query Commitment Revisited (2019)

We revisit the Normalized Query Commitment (NQC) query performance prediction (QPP) method. To this end, we suggest a scaled extension to a discriminative QPP framework and use it to analyze NQC. Using this analysis allows us to redesign NQC and suggest several options for improvement.
Current filamentation in point contact geometry and its 2D stationary model (1998)

Two-dimensional reconstructions of the filamentary current flow are shown, obtained by the spatially resolved photoluminescence of a sample of n-GaAs epitaxial layer with two point contacts. A mathematical model is constructed, based on a bistability of the local conductivity controlled by the local electric field strength. The interface between the high and low conductive states is assumed to occur always at a constant critical value of the field strength. Corresponding mathematical description of the model leads to the nonlinear Laplace free boundary problem. Its two-dimensional numerical solution is shown to satisfactorily reproduce the main characteristics of the filament observed in the experiment.
Electronic transport properties of individual 4,4′-bis(mercaptoalkyl)-biphenyl derivatives measured in STM-based break junctions (2010)

Electronic transport measurements of single, systematically varied 4,4'-bis(mercaptoalkyl)-biphenyl derivatives (MABP) are performed in a controlled test-device. The molecules are composed of a central biphenyl unit (BP) carrying two mercaptoalkyl substituents with different chain lengths (m, n = number of CH(2)-units), in the para-position of the BP unit. The total length of both spacers is m + n = 10. The molecular conductance of these individual MABPs deposited on Au (111) substrates is studied using STM-based break junctions. It is shown that the molecular conductance depends on the relative position of the BP unit within the molecule. In the case of the symmetric derivative 5BP5 a value of 0.07 +/- 0.01 nS is obtained, while for 1BP9 the molecular conductance is doubled and a value of 0.17 +/- 0.03 nS results. This relatively high value of conductance for the single Au(tip)-1BP9-Au(substrate) junction is attributed to an increased coupling of the BP unit to the adjacent electrode, i.e. the STM-tip or the Au-substrate. We address the role of the specific contact situation (-S-Au) and of the position of the electrically active molecular moiety and thus come to a deeper understanding of the electronic transport properties of 4,4'-bis(mercaptoalkyl)biphenyl derivatives.
ChemInform Abstract: The Catalytic Asymmetric Aldol Reaction of Aldehydes with Unsubstituted and Monosubstituted Silyl Ketene Acetals: Formation of anti‐β‐Hydroxy‐α‐methyl Esters. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Sensing Microsystem for High Resolution Pressure Gradient Measurement in Core-Flood Experiments (2019)

Investigating the permeability and porosity of geological samples is a routine element of geological studies, and of particular interest to the oil and gas industry. Core-flood experiments are commonly performed on rock samples to measure transport characteristics in the laboratory. This paper reports the design and implementation of a high resolution distributed pressure measurement system for core-flood experiments. A series of microfabricated pressure sensors are embedded in bolts housed within the pressurized polymer sheath that encases the rock core. A feedthrough technology has been developed to provide lead transfer between the sensors and system electronics across a 230-bar pressure difference. The system has been successfully benchtop tested with fluids such as synthetic oil and/or gas. Pressure measurements were recorded over a dynamic range of 20 bar with a resolution as small as 0.3 mbar.
The Office of the Past: Document Discovery and Tracking from Video (2005)

This paper presents an approach for reconstructing the physical state of documents and other objects on a desk over time using an overhead video camera. The history of the desktop is subsequently analyzed to enable a range of interesting queries. A desktop object is discovered when it first moves, and is tracked through the image sequence using change detection and motion segmentation techniques. The space-time structure of the scene is represented by a sequence of graphs where an "event", i.e., a change in the state of the scene, is modeled as a transition between subsequent graphs. We present two prototype applications that are based on these desktop reconstruction techniques. The first one allows the user to browse the structure and history of the desktop, and query documents of interest. The second application is a virtual desktop interface where the user can virtually manipulate the document stacks with mouse interaction.
Multiblock Copolymers with Hydrophilic-Hydrophobic Sequences for Proton Exchange Membranes (2008)

Abstract not Available.
Hybrid mounted micromachined aluminium hot-wire for near-wall turbulence measurements (2003)

We present the first micromachined metal hot-wire anemometer sensor for use in near-wall turbulence measurements. To measure close to the surface without the circuitry interfering with the flow, a novel hybrid assembly of the sensor has been developed. We present the design, fabrication and characteristics of this sensor.
Structome analysis of Escherichia coli cells by serial ultrathin sectioning reveals the precise cell profiles and the ribosome density (2017)

Structome analysis, the quantitative three-dimensional structural analysis of whole cells at the electron microscopic level, of Exophiala dermatitidis (black yeast), Saccharomyces cerevisiae, Mycobacterium tuberculosis (MTB) and Myojin spiral bacteria (MSB) have already been reported. Here, the results of the structome analysis of Escherichia coli cells based on transmission electron microscope observation of serial ultrathin sections was reported, and compared with the data obtained from phase contrast microscopy and scanning electron microscopy. On average, the cells had 0.89 μm in diameter, 2.47 μm in length and 1.16 fl (μm3) in cell volume in the structome analysis. Furthermore, E. coli cells had 26 100 ribosomes per whole cell with density of 2840 per 0.1 fl cytoplasm. The total ribosome number per cell was 15 times larger than that of MTB and about one-eighth of those of the yeast cells above. On the other hand, the ribosome density of E. coli cells are more than 13 times, 4 times, 2.5-times and 1.5-times higher than MSB, MTB, E. dermatitidis and S. cerevisiae, respectively. Finally, our ribosome enumeration data were compared between the structome-analyzed species and the relationship between the ribosome density and the growth rate among these species was discussed.
Application of P,N‐Sulfinyl Imine Ligands to Iridium‐Catalyzed Asymmetric Hydrogenation of Olefins. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
FPGA Emulation of Through-Silicon-Via (TSV) Dataflow Network for 3D Standard Chip Stacking System (2023)

Through-Silicon-Via (TSV) is expected to realize high-performance, low-power consumption, and lowcost 3D-LSI (Large Scale Integration) system. It is realized by integrating pre-manufactured chips with a 3D Standard Chip Stacking System (3D-SCSS) through a standard bus TSV connection. However, it is difficult to define a standard chip connection mechanism. This paper proposes an FPGA emulation of the TSV dataflow network for evaluating the performance of 3D-SCSS. To emulate 3D-SCSS, multiple-clock domains are assumed to overcome the problem of jitter in the global clock, which is a separated clock domain model. Simple dataflow experiments are done where processes are deployed to different chips and communicate among the chips in the 3D-SCSS. The evaluation shows that the emulation method is suitable to measure the latency performance of the proposed TSV dataflow network. (Keywords: 3D-LSI, TSV, FPGA, Emulation, Dataflow, 3D-SCSS)
Glaucomatous retinal nerve fibre layer defects may be identified in Stratus OCT images classified as normal (2008)

Our observations suggest that OCT images obtained in glaucoma eyes that are misclassified by the standard statistical analyses of Stratus OCT may contain information indicating RNFL defects. Thus, the current diagnostic ability of OCT in glaucoma can probably be extended.