gebhart/patrepeval huggingface dataset:
Programming strategies to reduce non-essential therapies and mortality - a systematic review (2013)

Purpose: Implantable cardioverter defibrillator (ICD) therapies are linked to a poor outcomes. Hence, programming strategies to reduce non-essential ICD therapies (Tx reduction programming) have been developed. This systematic review and meta-analysis of relevant studies sought to quantify the impact of Tx reduction programming on mortality. Methods: MEDLINE, EMBASE and other online databases were searched to identify relevant articles using standard methods. Studies that assessed mortality and followed patients for at least 6 months were included. Results were abstracted in duplicate and analyzed using Stata (v 11) statistical software using randomized effects models. Results: Five trials met the inclusion criteria, 3 with (EMPIRIC, MADIT-RIT & ADVANCE III) and 2 without (PREPARE & RELEVANT), a randomized comparator group. The 5 studies included 6,017 (2,774 conventional & 3,243 Tx reduction programming) patients. Most (79%) participants were male, had a history of ischemic heart disease (57%), and were prescribed beta-blockers (82%). Tx reduction programming reduced mortality by 33% (95% Confidence Interval (CI) 17% to 46%) as compared with conventional programming (FIGURE). No significant heterogeneity among the studies was observed (p = 0.6). Similar reductions in mortailty were observed when only the 3 randomized trials were included (29% reduction, 95% CI 8% to 45%) and when the 2 active therapy MADIT RIT groups were combined and compared to the 1 control group (32% reduction, 95% CI 15% to 46%). Figure 1 Figure 1 Conclusions: Therapy reduction programming is associated with a large, significant and consistent reduction in mortality. The reasons for this reduction in mortality are unclear and merit further study.
Subtalar distraction bone block arthrodesis (2001)

This retrospective study analyses the results of subtalar bone block distraction arthrodesis used in the treatment of late complications of calcaneal fractures, acute severely comminuted fractures, nonunion (and malunion) of attempted subtalar arthrodeses, avascular necrosis of the talus, and club-foot deformity. Of 39 patients (41 feet) who had this procedure, 35 (37 feet) returned for follow-up after a mean of 70 months (26 to 140). There were 24 men (25 feet) and 11 women (12 feet) with a mean age of 41 years (16 to 63). Each completed a standardised questionnaire, based on the hindfoot-scoring system of the American Orthopaedic Foot and Ankle Society and were reviewed both clinically and radiologically. Of the 37 operations, 32 (87%) achieved union. The mean hindfoot score (maximum of 94 points) increased from 21.1 points (8 to 46) preoperatively to 68.9 (14 to 82) at the final follow-up. The mean talocalcaneal and calcaneal pitch angles were 20.5 degrees and 4.9 degrees before operation, 25.9 degrees and 8.3 degrees immediately after, and 24.6 degrees and 7.7 degrees at the final follow-up, respectively. The mean talar declination angle improved from 6.5 degrees (-10 to 22) before operation to 24.8 degrees (14 to 32) at the final follow-up. The mean talocalcaneal height increased from 68.7 mm before operation to 74.5 mm immediately after and 73.5 mm at the final follow-up. Of the 37 arthrodeses available for review, 32 were successful; 29 patients (30 arthrodeses) were satisfied with the procedure. Minimal loss of hindfoot alignment occurred when comparing radiographs taken immediately after operation and at final follow-up.
158: Testosterone Up-Regulates Androgen Receptor and Changes Bladder Mass and Collagen to Smooth Muscle Ratio (2005)

You have accessJournal of UrologyDiscussed Poster, Sunday, May 22, 2005 8:00 am - 12:00 pm1 Apr 2005158: Testosterone Up-Regulates Androgen Receptor and Changes Bladder Mass and Collagen to Smooth Muscle Ratio Bingyin Wang, Youxin Ye, Barry R. Behr, and Linda D. Shortliffe Bingyin WangBingyin Wang More articles by this author , Youxin YeYouxin Ye More articles by this author , Barry R. BehrBarry R. Behr More articles by this author , and Linda D. ShortliffeLinda D. Shortliffe More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34423-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "158: Testosterone Up-Regulates Androgen Receptor and Changes Bladder Mass and Collagen to Smooth Muscle Ratio." The Journal of Urology, 173(4S), p. 43 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 43 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Bingyin Wang More articles by this author Youxin Ye More articles by this author Barry R. Behr More articles by this author Linda D. Shortliffe More articles by this author Expand All Advertisement PDF downloadLoading ...
ChemInform Abstract: Growth and Sintering of Fullerene Nanotubes. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Automated Screening for Social Anxiety, Generalized Anxiety, and Depression From Objective Smartphone-Collected Data: Cross-sectional Study (2021)

We demonstrate the ability of a common set of features to act as predictors in the models of both SAD and depression. This suggests that the types of behaviors that can be inferred from smartphone-collected data are broad indicators of mental health, which can be used to study, assess, and track psychopathology simultaneously across multiple disorders and diagnostic boundaries.
A scan-based configurable, programmable, and scalable architecture for sliding window-based operations (1999)

In this paper, a scan-based programmable, configurable, and scalable architecture is proposed. This architecture is suitable for a wide range of applications in signal processing requiring programmability and presenting high bandwidth and real-time requirements beyond the capacity of off-the-shelf DSPs or FGPAs. The architecture is specifically targeting a very common type of signal processing operation: sliding window operations (SWOs). Through various examples, the "programmability, configurability, and scalability" of the proposed architecture are illustrated. Our approach is then compared to traditional programmable architectures with coefficient registers in terms of gate count, speed (delay), and other implementation-related issues. This comparison reveals that our architecture leads to less complex solutions with comparable performance. In general, this approach can be seen as an alternative offering reduced recurrent costs at the expense of potentially higher nonrecurrent costs, which makes it very attractive for high volume production.
Clonal Analyses of Retroviral Vector Integrations in ADA-SCID Patients Treated with Stem Cell Gene Therapy. (2006)

Abstract Gene transfer into hematopoietic stem/progenitor cells (HSC) by gammaretroviral vectors is an effective treatment for patients affected by severe combined immunodeficiency (SCID) due to adenosine deaminase (ADA)-deficiency. Recent studied have indicated that gammaretroviral vectors integrate in a non-random fashion in their host genome, but there is still limited information on the distribution of retroviral insertion sites (RIS) in human long-term reconstituting HSC following therapeutic gene transfer. We performed a genome-wide analysis of RIS in transduced bone marrow-derived CD34+ cells before transplantation (in vitro) and in hematopoietic cell subsets (ex vivo) from five ADA-SCID patients treated with gene therapy combined to low-dose busulfan. Vector-genome junctions were cloned by inverse or linker-mediated PCR, sequenced, mapped onto the human genome, and compared to a library of randomly cloned human genome fragments or to the expected distribution for the NCBI annotation. Both in vitro (n=212) and ex vivo (n=496) RIS showed a non-random distribution, with strong preference for a 5-kb window around transcription start sites (23.6% and 28.8%, respectively) and for gene-dense regions. Integrations occurring inside the transcribed portion of a RefSeq genes were more represented in vitro than ex vivo (50.9 vs 41.3%), while RIS &lt;30kb upstream from the start site were more frequent in the ex vivo sample (25.6% vs 19.4%). Among recurrently hit loci (n=50), LMO2 was the most represented, with one integration cloned from pre-infusion CD34+ cells and five from post-gene therapy samples (2 in granulocytes, 3 in T cells). Clone-specific Q-PCR showed no in vivo expansion of LMO2-carrying clones while LMO2 gene overexpression at the bulk level was excluded by RT-PCR. Gene expression profiling revealed a preference for integration into genes transcriptionally active in CD34+ cells at the time of transduction as well as genes expressed in T cells. Functional clustering analysis of genes hit by retroviral vectors in pre- and post-transplant cells showed no in vivo skewing towards genes controlling self-renewal or survival of HSC (i.e. cell cycle, transcription, signal transduction). Clonal analysis of long-term repopulating cells (&gt;=6 months) revealed a high number of distinct RIS (range 42–121) in the T-cell compartment, in agreement with the complexity of the T-cell repertoire, while fewer RIS were retrieved from granulocytes. The presence of shared integrants among multiple lineages confirmed that the gene transfer protocol was adequate to allow stable engraftment of multipotent HSC. Taken together, our data show that transplantation of ADA-transduced HSC does not result in skewing or expansion of malignant clones in vivo, despite the occurrence of insertions near potentially oncogenic genomic sites. These results, combined to the relatively long-term follow-up of patients, indicate that retroviral-mediated gene transfer for ADA-SCID has a favorable safety profile.
Chemical Bond Stabilization and Exciton Management by CN Modified Host Material for Improved Efficiency and Lifetime in Blue Phosphorescent Organic Light‐Emitting Diodes (2016)

A high triplet energy host material for improved efficiency and elongated lifetime is developed by modifying carbazole linked terphenyl with a CN substituent. The CN modification strengthens electron injection and transport of the host material, which reduces the driving voltage, improved quantum efficiency, and power efficiency of blue phosphorescent organic light‐emitting diodes. Furthermore, the CN modification also extends the lifetime of the blue device due to the chemical bond stabilizing effect of the CN moiety in radical, anion, and cation states. Therefore, the molecular design modifying the backbone structure with CN is an efficient approach for high efficiency and long lifetime.
Introducing 28-nm stratix VFPGAs: Built for bandwidth (2010)

This article consists of a collection of slides from the author's conference presentation on Altera's 28-nm Stratix V FPGA product line. Some of the specific topics discussed include: the special features, system specifications, and system design for this product line; FPGA system architectures; applications for use; platforms supported; processing capabilities; memory capabilities; and targeted markets.
Coruscol A, a New Metabolite from the Marine-Derived Fungus Penicillium Species (2000)

A new metabolite possessing a 1,3-dioxane ring, coruscol A (1), was isolated from the mycelium of the fungus Penicillium sp., which was separated from the Okinawan marine bivalve Mytilus coruscus, and the structure was elucidated by spectroscopic data.
Peptidomics of Haemonchus contortus (2021)

The nematode <i>Haemonchus contortus</i> (the barber's pole worm) is an endoparasite infecting wild and domesticated ruminants worldwide. Widespread anthelmintic resistance of <i>H. contortus</i> requires alternative strategies to control this parasite. Neuropeptide signaling represents a promising target for anthelmintic drugs. Identification and relative quantification of nematode neuropeptides are, therefore, required for the development of such therapeutic targets. In this work, we undertook the profiling of the whole <i>H. contortus</i> larvae at different stages for the direct sequencing of the neuropeptides expressed at low levels in these tissues. We set out a peptide extraction protocol and a peptidomic workflow to biochemically characterize bioactive peptides from both first-stage (L1) and third-stage larvae (L3) of <i>H. contortus</i>. This work led to the identification and quantification at the peptidomic level of more than 180 mature neuropeptides, including amidated and nonamidated peptides, arising from 55 precursors of <i>H. contortus</i>. The differential peptidomic approach provided evidence that both life stages express most FMRFamide-like peptides (FLPs) and neuropeptide-like proteins (NLPs). The <i>H. contortus</i> peptidome resource, established in this work, could add the discovery of neuropeptide system-targeting drugs for ruminants.
Steganography and collusion in cryptographic protocols (2006)

Steganography, the hiding of covert messages inside innocuous communication, is an active area of cryptographic research. Recent research has shown that provably undetectable steganography is possible in a wide variety of settings. We believe that the existence of such undetectable steganography will have far reaching implications. In this thesis, we investigate the impact of steganography on the design of cryptographic protocols. In particular, we show that all existing cryptographic protocols allow malicious players to collude and coordinate their actions by steganographicly hiding covert messages inside legitimate protocol traffic. Such collusion is devastating in many settings, and thus we argue that its elimination is an important direction for cryptographic research. 
Defeating such steganographic collusion requires not only new cryptographic protocols, but also a new notion of protocol security. Traditional notions of protocol security attempt to minimize the injuries to privacy and correctness inflicted by malicious participants who collude during run-tune. They do not, however, prevent malicious parties from colluding and coordinating their actions in the first place! We therefore put forward the notion of a collusion-free protocol which guarantees that no set of players can use the protocol to maliciously coordinate their actions. As should be expected, such a strong notion of security is very difficult to achieve. We show that achieving collusion-free security is impossible in a model with only broadcast communication and that even with physically private communication (e.g. physical envelopes) there are still many ideal functionalities that have no collusion-free protocols. 
Fortunately, under natural assumptions collusion-free protocols exist for an interesting class of ideal functionalities. Assuming the existence of trapdoor permutations, we construct collusion-free protocols, in a model with both broadcast messages and physical envelopes, for every finite ideal functionality in which all actions are public.
Coexistence of Buckled and Flat Monolayers (1998)

The minimum surface tension and respreadability of a surfactant monolayer is limited by a two to three dimensional instability called collapse. Liquid-condensed or solid phase monolayers collapse via fracture followed by loss of material. Liquid-expanded phase monolayers collapse by solubilization into the subphase. Monolayers that retain a continuous liquid-expanded phase network surrounding islands of liquid-condensed or solid phase collapse at low surface tensions via a localized, large amplitude buckling. The buckled regions coexist with the flat monolayer, remain attached to the interface, and reversibly reincorporate into the monolayer upon expansion.
A Soft-Switched Asymmetric Flying-Capacitor Boost Converter With Synchronous Rectification (2015)

The multilevel flying-capacitor boost converter was analyzed for asymmetric voltage operation-this permits loss optimization that takes advantage of different voltage class MOSFETs. A cost-motivated design of a suitable zero-voltage zero-current switching snubber is then developed that permits a great reduction of the inductor size. With the proposed snubber, synchronous rectification operation is compared to that of diode boost, with a particular attention to the contribution of nonlinear MOSFET parasitics. Experimental results from a 2-kW/30-kHz prototype justify the effectiveness of this solution with a conversion efficiency around 99% ± 0.1% for a wide load range.
Cavity requirements for optimizing Tm/Ho-doped coaxial fiber laser systems (Conference Presentation) (2020)

Coaxial fiber lasers, consisting of a Ho-doped core surrounded by a Tm-doped ring, are studied via experiments and numerical simulations. Previous simulations indicated that coaxial fiber lasers have the potential to reach power conversion efficiencies of up to 54%, but experiments have yielded much lower efficiencies. To understand this difference, a wavelength dimension is added to the standard model and simulations are compared to experiments. An output coupler is designed to optimize the efficiency of coaxial fiber systems, and a path towards realizing the predicted 54% efficiency is presented.
Isoform selectivity of 3-125I-iodo-alpha-methyl-L-tyrosine membrane transport in human L-type amino acid transporters. (2003)

(125)I-IMT transport was hLAT1 selective. Investigations on the isoform selectivity of (125)I-IMT transport with other transporters are anticipated.
Performance boost of crystalline In-Ga-Zn-O material and transistor with extremely low leakage for IoT normally-off CPU application (2017)

The worldwide first 100MHz dynamic oxide semiconductor RAM (DOSRAM) is successfully demonstrated using a new high-mobility crystalline In-Ga-Zn-O (IGZO) material. The new IGZO exhibits around two times carrier mobility of conventional IGZO, while still achieving an extremely low off-state leakage (I <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</inf> ) at ∼10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−21</sup> A (zA) level. Attributed to DOSRAM performance improvement, 100MHz normally-off (Noff) CPU is successfully demonstrated with drastically reduced power consumption (∼94% power reduction for ARM Cortex-M0 and ∼70% power reduction for memory), making it a promising candidate for IoT application. In addition, an OS-FPGA is successfully fabricated by integration of 65nm SiFET and 60nm oxide semiconductor FET (OSFET) with an operation frequency of 360MHz. The application of the OSFET in analog circuits will also be discussed in this paper.
Efficacy-Driven Quality Control Platform for Chinese Herbal Medicine (2014)

The quality control of CHM is always a key issue for the clinical usage, and also is a secure for high quality of clinical trials, especially in the consistency and controllability (5,6). Great progress has been made in the quality control of CHM due to modern separation and characterization techniques. Briefly, it can be divided into three stages. The first stage was the usage of identification of CHM based on material medical's morphology, one or two markers' thin-layer chromatography (TLC) (7). The morphological identification was described in the 1953 and 1963 editions of the Chinese Pharmacopeia. Since 1985, TLC has been employed for the qualitative evaluation of CHM (8). Morphological identification can give a quick identification of CHM; and TLC method has the advantages of operating conveniently, quick identification and preliminary quantification of marker compounds. However, morphological identification cannot explore the substantial basis of CHM; while TLC also has the weaknesses of limitation in multiple compounds detection, low selectivity in quantification. CHM is a multicomponent combination, so just use TLC method for several marker compounds' quality control cannot reflect the real quality of CHM. Nevertheless, the chosen of marker compounds are mostly based on main compounds in CHM, which may have no relevance with pharmacological activity. Based on these weaknesses, Researchers started to focus on multiple active compounds analysis method. So the second stage was the application of comprehensive methods which reflect the characteristics of multiple targets and synergistic action of CHM using fingerprint (including chromatographic and spectroscopic ones, contain TLC, HPLC, GC, CE, IR, NIR, NMR, DNA, GC-MS, LC-MS, LC-DAD- MSn, and LC-DAD-NMR) (9,10). It presents the entire composition information and fulfills the TCM characteristics. Therefore, fingerprint analysis has been internationally accepted for the quality control of herbal medicines (8). To combine chemical character with bioactivity, bio-fingerprint and metabolic fingerprint have also been used for directly selecting the marker constituents for quality control (11). However, these marker components were selected by preliminary comparison of fingerprints, more work need to be done for the activity confirmation.
Properties of BaO–R 2 O 3 – Ga 2 O 3 –GeO 2 (R = Y, Al, La, and Gd) Glasses (1994)

Barium gallogermanate glasses were prepared with substitutions of Al 2 O 3 , Y 2 O 3 , La 2 O 3 , and Gd 2 O 3 for Ga 2 O 3 . The effects of these substitutions on the glass transformation temperature, viscosity, thermal expansion, and molar volume have been determined. The changes in properties associated with each substitutional ion are consistent with structural roles reported for these ions in other glasses. Aluminum acts as an intermediate with [AlO 4 – ] tetrahedra substituting directly for [GaO 4 – ] tetrahedra. Yttrium and gadolinium act as “atypical” modifier ions because of their large field strengths. Finally, the properties of the La 2 O 3 ‐substituted glasses indicate a possible dual structural role for La 3+ ions in these glasses.
An Assessment of GPS Spoofing Detection Via Radio Power and Signal Quality Monitoring for Aviation Safety Operations (2020)

Due to the ever-growing threat of GPS spoofing, it has become necessary for the aviation sector to develop an effective means of detection. This article focuses on two complementary spoofing-detection techniques that are available on commercial GPS receivers and thus require no additional hardware to operate. The primary methodology for detection is using a combination of radio power monitoring metrics, levering both automatic gain control and C/N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> measurements, along with multiple correlations for signal distortion to provide a best practices spoofing-detection algorithm, which is able to distinguish between interference and spoofing. The article first assesses nominal statistics for both metrics compiled from more than 250 h of nominal data collected from multiple wide area augmentation system stations. These data are compared to previous collections to validate the thresholds and false alarms rates and establish a complete testing methodology. These tests and thresholds are then assessed with the Texas spoofing test battery series of GPS spoofing data sets to confirm detection capabilities. Finally, these tests and thresholds are applied to assess the GPS signal of six extended flights over the United States to assess the performance on an aircraft.