gebhart/patrepeval huggingface dataset:
Harvesting Highly Electronically Excited Energy to Triplet Manifolds: State-Dependent Intersystem Crossing Rate in Os(II) and Ag(I) Complexes (2012)

A series of newly synthesized Os(II) and Ag(I) complexes exhibit remarkable ratiometric changes of intensity for phosphorescence versus fluorescence that are excitation wavelength dependent. This phenomenon is in stark contrast to what is commonly observed in condensed phase photophysics. While the singlet to triplet intersystem crossing (ISC) for the titled complexes is anomalously slow, approaching several hundred picoseconds in the lowest electronic excited state (S(1) → T(1)), higher electronic excitation leads to a much accelerated rate of ISC (10(11)-10(12) s(-1)), which is competitive with internal conversion and/or vibrational relaxation, as commonly observed in heavy transition metal complexes. The mechanism is rationalized by negligible metal d orbital contribution in the S(1) state for the titled complexes. Conversely, significant ligand-to-metal charge transfer character in higher-lying excited states greatly enhances spin-orbit coupling and hence the ISC rate. The net result is to harvest high electronically excited energy toward triplet states, enhancing the phosphorescence.
A simple algorithm to control two-phase induction motors using a two-leg VSC (2014)

This paper proposes a novel control method for two-phase induction motors using a two-leg voltage-sourced converter (VSC) in high speed applications and field-weakening regions. The proposed Approximate Stator Flux Control (ASFC) method is based on the dynamic model of two-phase induction motors and provides good dynamic behavior of the drive system. The switching strategy of ASFC method is proposed and the speed of the rotating field and the average switching frequency of the VSC are derived. ASFC method controls the speed of the rotating field by adjusting the stator flux modulus. No need to use current transducers and mechanical sensors makes implementation cost of ASFC comparable with that of the conventional scalar control system. Through simulations, the performance of the proposed two-phase ASFC method is evaluated and compared with the scalar control method. In addition, the correctness of the presented theories of ASFC method is validated by dynamic simulations.
Nobiletin Prevents Body Weight Gain and Bone Loss in Ovariectomized C57BL/6J Mice (2014)

Obesity and osteoporosis are associated with estrogen deficiency following menopause. Therefore, it is important to prevent and treat both disorders to maintain a healthy life in postmenopausal women. Nobiletin, a polymethoxylated flavone, exhibits various pharmacologic effects, including anti-tumor and anti-inflammatory activities. Therefore, in this study, we examined the effects of nobiletin on obesity, obesity-related metabolic disorders, and bone mass in ovariectomized (OVX) mice. Mice were divided into four groups and underwent sham operation or OVX. OVX mice were treated with 50 or 100 mg/kg nobiletin, or received vehicle alone (0.3% carboxyl methyl cellulose/0.5% dimethyl sulfoxide). Nobiletin decreased body weight gain and white adipose tissue weight in OVX mice. Nobiletin also decreased triglyceride levels, and tended to reduce plasma total cholesterol and glucose levels. Additionally, nobiletin prevented the reduction in bone mineral density of the trabecular region of the femur in OVX mice. Taken together, our results suggest that nobiletin improves adiposity, dyslipidemia, hyperglycemia, and prevents bone loss in OVX mice. Therefore, nobiletin is expected to have beneficial effects for the prevention and improvement of metabolic disorders and osteoporosis in postmenopausal women.
Universal Colorimetric Detection of Nucleic Acids Based on Polydiacetylene (PDA) Liposomes (2008)

Abstract A universal colorimetric method for the detection of nucleic acids, based on ionic interactions by polydiacetylene (PDA) liposomes, is described. Primary and quaternary amine‐modified diacetylene monomers were synthesized and used to generate positively charged PDA liposomes. The resulting PDA sensors showed a dramatic color change from blue to red upon the addition of nucleic acids amplified by using the polymerase chain reaction (PCR) due to the stimuli caused by ionic interactions between the positively charged PDA and negatively charged phosphate backbone of the nucleic acids. The color change that takes place can be simply detected by the naked eye. Compared with quaternary amine‐functionalized PDA vesicles, the primary amine‐functionalized PDA underwent a more intense color transition under optimized conditions. By using the PDA‐based colorimetric sensor, nucleic acids amplified by common PCR reaction, whose typical concentration is around 100 nM, can be readily detected. Since implementation of this universal colorimetric method is simple, rapid and does not require any sophisticated instrumentation, it should have greatly enhanced applications as a technology for DNA diagnosis.
Surface roughness and vibration study of an accelerometer mount used in a helicopter health usage and management system (2003)

The results of a study examining an accelerometer mount used in a Helicopter Health Usage and Management System (HUMS) is presented. The accelerometer mount is an important component in the vibration measurement process, transmitting the vibration signature of the subject component to the accelerometer transducer. The effect of surface roughness is studied between the accelerometer mount and the subject component by generating a dimensionless transfer function between the accelerometer mount and a reference block for several surface conditions. The transfer functions and time domain results provide some insight into the vibration characteristics of the accelerometer mount. Multiple iterations performed for each test condition provide some statistical information. The results show that, within the test cases.. Surface roughness is a higher order effect. The primary driver for variability in the data results from the installation, removal, and reinstallation of the accelerometer mount.
Suppression of Si etching during hydrogen annealing of silicon-on-insulator (2002)

Generally, polishing is employed as the final treatment of silicon-on-insulator (SOI) at the expense of SOI thickness reduction, because surface microroughness affects the gate oxide integrity. Hydrogen annealing of SOI wafers (Sato and Yonehara, 1994) was originated to replace the polishing, and was traced by several groups. This novel method is advantageous in that there is no thickness reduction in principle. However, in view of the Si etching during hydrogen annealing, various etching rates have been reported in the literature, leading to the question of how much Si is consumed or how much SOI thickness reduction is suppressed. In this paper, Si etching during hydrogen annealing is investigated by using ELTRAN wafers, which are fabricated by transferring epitaxial layers on porous Si on to handle wafers. The lowest reported etching rate to date is achieved.
Considering the chemical energy requirements of the tri-n-propylamine co-reactant pathways for the judicious design of new electrogenerated chemiluminescence detection systems (2015)

The introduction of a 'co-reactant' was a critical step in the evolution of electrogenerated chemiluminescence (ECL) from a laboratory curiosity to a widely utilised detection system. In conjunction with a suitable electrochemiluminophore, the co-reactant enables generation of both the oxidised and reduced precursors to the emitting species at a single electrode potential, under the aqueous conditions required for most analytical applications. The most commonly used co-reactant is tri-n-propylamine (TPrA), which was developed for the classic tris(2,2'-bipyridine)ruthenium(II) ECL reagent. New electrochemiluminophores such as cyclometalated iridium(III) complexes are also evaluated with this co-reactant. However, attaining the excited states in these systems can require much greater energy than that of tris(2,2'-bipyridine)ruthenium(II), which has implications for the co-reactant reaction pathways. In this tutorial review, we describe a simple graphical approach to characterise the energetically feasible ECL pathways with TPrA, as a useful tool for the development of new ECL detection systems.
Solvent selection causes remarkable shifts of the “Ouzo region” for poly(lactide-co-glycolide) nanoparticles prepared by nanoprecipitation (2015)

Polymer nanoparticles (NPs) offer versatile novel biological features of interest for drug delivery applications. "Ouzo diagrams" allowed for a systematic manufacture of specified colloidal formulations by the widely used nanoprecipitation process. Surprisingly, despite the well-documented relevance of the applied organic solvent for nanoprecipitation, its effect on the actual status of the "Ouzo region" was so far not studied. Herein, investigations were undertaken to account for the potential impact of the solvent type on the "Ouzo diagrams" for poly(lactide-co-glycolide) (PLGA) and tetrahydrofuran (THF), 1,4-dioxane, acetone and dimethyl sulfoxide (DMSO). The "Ouzo region" shifted considerably to higher polymer fractions upon solvent change (rank order: THF < 1,4-dioxane < acetone < DMSO). Assuming a one-to-one transformation of detached PLGA-bearing solvent droplets (droplet diameter for THF: ∼800 nm, 1,4-dioxane: ∼700 nm, acetone: ∼500 nm and DMSO: ∼300 nm) into non-divisible polymer aggregates upon solvent displacement, facilitated to predict the size of NPs found within the "Ouzo region" (size range: 40-200 nm). In conclusion, application of "Ouzo diagrams" is a valuable tool for drug delivery research and will most-likely replace the "trial-and-error"-approach to identify the operating window for the production of stable colloidal formulations by the nanoprecipitation technique.
Combinatorial islet protective therapeutic approaches in β‐cell transplantation: Rationally designed solutions using a target product profile (2023)

While progress has been made in the development of islet cell transplantation (ICT) as a viable alternative to the use of exogenous insulin therapy in the treatment of type 1 diabetes, it has not yet achieved its full potential in clinical studies. Ideally, ICT would enable lifelong maintenance of euglycemia without the need for exogenous insulin, blood glucose monitoring or systemic immune suppression. To achieve such an optimal result, therapeutic approaches should simultaneously promote long-term islet viability, functionality, and localized immune protection. In practice, however, these factors are typically tackled individually. Furthermore, while the requirements of optimal ICT are implicitly acknowledged across numerous publications, the literature contains few comprehensive articulations of the target product profile (TPP) for an optimal ICT product, including key characteristics of safety and efficacy. This review aims to provide a novel TPP for ICT and presents promising tried and untried combinatorial approaches that could be used to achieve the target product profile. We also highlight regulatory barriers to the development and adoption of ICT, particularly in the United States, where ICT is only approved for use in academic clinical trials and is not reimbursed by insurance carriers. Overall, this review argues that the clear definition of a TPP in addition to the use of combinatorial approaches could help to overcome the clinical barriers to the widespread adoption of ICT for the treatment of type 1 diabetes.
ChemInform Abstract: Sulfoxides and Stereochemical Control in Organometallic Chemistry (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Phase II Study of Androgen Synthesis Inhibition with Ketoconazole, Hydrocortisone, and Dutasteride in Asymptomatic Castration-Resistant Prostate Cancer (2009)

The response proportion to ketoconazole, hydrocortisone, and dutasteride was at least comparable with previous studies of ketoconazole alone, whereas time to progression was substantially longer. Combination therapies targeting multiple steps in androgen synthesis warrant further investigation.
Supplementary Figure 5 from Effects of HER Family–targeting Tyrosine Kinase Inhibitors on Antibody-dependent Cell-mediated Cytotoxicity in HER2-expressing Breast Cancer (2023)

&lt;p&gt;All ADCC ratios from Figure 3 and trastuzumab/pertuzumab ADCC comparison&lt;/p&gt;
Control monitoring of routing bits and data packets in WDM networks using wavelength-to-time mapping (1999)

We demonstrate a wavelength-to-time technique for control monitoring bits, data packets, and channel powers in a wavelength-division-multiplexed network. We recover the routing header bits across parallel wavelengths as well as determine the existence of data packets for switching purposes. We show results for a routing-bit monitor of multiple channels with a speed of 2.5 Gb/s and a packet/frame monitor for multiple channels with a speed of 100 MHz.
The purine nucleosides adenosine and guanosine delay axonal degeneration in vitro (2009)

Axonal degeneration is a key component of many neurodegenerative diseases. Injured axons undergo a program of self-destruction termed Wallerian degeneration that is an active, well-regulated process. The pathways leading to axon fragmentation are uncharacterized, but experiments with wld(s) mutant mice led to the discovery that over-expression of NMN adenylyltransferase 1 or treatment with NAD(+) can inhibit axonal degeneration. In this study, we show that the purine nucleosides adenosine and guanosine, but not inosine, inhibit injury-induced axonal degeneration in cultured dorsal root ganglia neurons. Axons can be preserved by adding adenosine within 6 h of the axonal injury. The presence of adenosine was required continuously after the injury to maintain axonal protection. Together these results suggest that adenosine does not alter the neuronal response to injury, but instead inhibits a local axonal pathway necessary for the commitment and/or execution of the axon destructive program.
Search for Lorentz and CPT violation using sidereal time dependence of neutrino flavor transitions over a short baseline (2017)

A class of extensions of the Standard Model allows Lorentz and CPT violations, which can be identified by the observation of sidereal modulations in the neutrino interaction rate. A search for such modulations was performed using the T2K on-axis near detector. Two complementary methods were used in this study, both of which resulted in no evidence of a signal. Limits on associated Lorentz and CPT-violating terms from the Standard Model extension have been derived by taking into account their correlations in this model for the first time. These results imply such symmetry violations are suppressed by a factor of more than 10(20) at the GeV scale.
Sorption Properties of Mesoporous Multilayer Thin Films (2016)

The vapor sorption properties of multilayers made of ordered mesoporous thin films with tailored composition\nand mesostructure are herein investigated. Optical reflectance measurements versus partial pressure of several\nvapors are performed to analyze the interplay between the affinity to and the accessibility of the different\ntypes of layers in the structure. We find that the behavior of a mesoporous oxide layer within the multilayer\nlargely differs from that of the isolated thin film, its sorption properties being determined by the interaction\nwith neighboring films. An explanation of the phenomena observed in these complex systems is provided in\nterms of the pore size, the affinity of each type of layer to specific compounds, and the effect of neighboring\nlayers in the sorption properties of bilayers by an independent environmental ellipsometric study.
Flavor and Other Quality Factors of Enzyme-peeled Oranges Treated with Citric Acid (2007)

Oranges can be satisfactorily processed for fresh slices using a process of enzyme infiltration under vacuum. Scored ‘Valencia’ and ‘Hamlin’ oranges were placed under 90 kPa vacuum in water, 1% citric acid (CA), or 1000 ppm pectinase (Ultrazym) at 30 °C for 2 min followed by 30 min incubation in air. After peeling, fruit were washed, cut, and all but CA-infused slices were dipped in water or 1% CA for 2 min. Drained slices were placed in sealed 454-mL deli containers and stored at 5 °C for up to 21 days. All ‘Valencia’ slices had microbial counts less than 1.0 log cfu·g −1 (cfu = colony-forming units) after 7 days storage, and slices from CA-infused fruit had less than 1.0 log cfu·g −1 after 21 days storage. For ‘Hamlin’, CA dips controlled bacterial growth on slices from water-infused oranges, except at 14 days. Enzyme-infused oranges resulted in slices with lower counts for both cultivars. CA-treated sliced (post enzyme treatment or by infusion) oranges had higher titratable acidity initially (‘Hamlin’) and after 14 days (‘Valencia’). When presented to a taste panel, ‘Valencia’ slices from enzyme-peeled fruit were preferred for texture after 2 days and 8 days in storage. In contrast, slices from fruit infused with water or citric acid were least preferred, were firmer, and had thicker segment membranes. Appearance of enzyme-treated fruit was preferred for ‘Hamlin’ oranges. Enzyme treatments increased levels of aroma volatiles, methanol and methyl butanoate, in ‘Hamlin’ slices, but overall sensory flavor data were unaffected.
Degradation and deposition of amyloid AA fibril are tissue specific (1987)

The complete amino acid sequences of two related AA proteins (Mr 9700 and 5300) derived from thyroid tissue from a patient, NOR, with the autosomal recessive disease familial Mediterranean fever were determined. Heterogeneity found at position 52 indicates these proteins are fragments of two allelic or isotypic SAA precursor molecules similarly degraded at unusual sites and deposited in the thyroid. Degradation appears to be tissue and/or enzyme(s) specific since the carboxy terminus of both fragments is Ala-Ala and is different from other AA amyloid fibrils extracted from various tissues in different patients. Electron micrographic studies reveal these fragments retain the characteristics of native amyloid fibrils under physiological conditions even after exposure to dissociating agents.
Macrophage Inhibitor, Semapimod, Reduces Tumor Necrosis Factor-Alpha in Myocardium in a Rat Model of Ischemic Heart Failure (2004)

Pharmaceutical agents aimed at reducing tumor necrosis factor-alpha (TNF-alpha) levels appeared to be attractive possibilities in the medical management of heart failure, as heart failure was shown to be associated with high TNF-alpha levels. However, therapies specifically targeting TNF-alpha failed to show any survival benefit. We examined whether a broad inhibition of inflammatory cytokine production secondary to macrophage inhibition would be more effective at improving cardiac function in the setting of heart failure. To this end, we studied Semapimod (formerly known as CNI-1493), a synthetic guanylhydrazone that inhibits macrophage activation and the production of several inflammatory cytokines. Left anterior descending coronary ligation surgery was performed on each animal to induce a myocardial infarction. After confirming heart failure by echocardiography, the animals were randomly assigned to one of four groups: (1) rats with myocardial infarct receiving high-dose Semapimod, 10 mg/kg/d (MI-H, N = 13); (2) rats with myocardial infarct receiving low-dose Semapimod, 3 mg/kg/d (MI-L, N = 9); (3) rats with myocardial infarct receiving vehicle treatment, 2.5% mannitol in water (MI-0, N = 9); and (4) control rats with sham operation and vehicle treatment (Sham, N = 10). Both Semapimod and vehicle treatments were administered by daily tail vein injections over a course of five days. Echoes were repeated at 2, 5, and 9 weeks following treatment. At 9 weeks, hemodynamic data were collected and the animals were euthanized. Trichrome staining was done to assess infarct, and immunohistochemistry was performed to assess TNF-alpha levels. Prior to drug administration, serum was taken from 5 random rats. No detectable level of TNF-alpha was seen (lower limit of detection for the assay used = 12.5 pg/mL). Also prior to any treatment, echocardiography confirmed significant cardiac impairment of rats undergoing LAD ligation as compared with sham. Over the course of the 9 weeks, there were 4 deaths, all in the MI-H group. There was no difference between Semapimod-treated animals and vehicle-treated MI animals in any echocardiographic or hemodynamic parameter. TNF-alpha staining in the noninfarcted region was evident only in the MI groups, not the sham group. When blindly compared on a semiquantitative scale (ie, 0 = no visible staining to 3 = marked staining), a significant difference in staining was observed between MI-0 versus MI-H (1.19 +/- 0.32 versus 0.33 +/- 0.14; P = 0.03) and between MI-0 and MI-L (1.19 +/- 0.32 versus 0.39 +/- 0.22; P = 0.05). In this setting, despite the fact that Semapimod treatment decreased tissue TNF-alpha levels, it did not improve cardiac function, and at high doses it was associated with higher mortality. These results in a rodent model confirm the results of clinical trials with etanercept and infliximab (ie, that decreasing TNF levels in plasma or tissues does not improve cardiac function and may actually increase mortality).
Semantic Management of Web Services using the Core Ontology of Services (2005)

Different Web Service standards like WSDL, WS-Security, WS-Policy etc., henceforth referred to as WS*, factorize Web Service management tasks into different aspects, such as input/output, workflow, or security. The advantages of WS* are multiple and have already achieved industrial impact. WS* descriptions are exchangeable and developers may use different implementations for the same Web Service description. The disadvantages of WS*, however, are also apparent: even though the different standards are complementary, they must overlap and one may produce models composed of different WS* descriptions, which are inconsistent with each other, but the reasons for the inconsistencies are not easily determined. This is the case because there is no coherent conceptual model of WS*, i.e. terms with equivalent semantics are introduced differently in the respective XML-DTDs. Thus, it is impossible to ask for conclusions that come from integrating different WS* descriptions. Hence, discovering such Web Service management problems or asking for other similar kinds of conclusions that derive from the integration of WS* descriptions remains a purely manual task to be done by the software developers accompanied by little to no formal machinery.