gebhart/patrepeval huggingface dataset:
Polarized RPE Secretome Preserves Photoreceptors in Retinal Dystrophic RCS Rats (2023)

Retinal degenerative diseases, including age-related macular degeneration (AMD) and retinitis pigmentosa, lack effective therapies. Conventional monotherapeutic approaches fail to target the multiple affected pathways in retinal degeneration. However, the retinal pigment epithelium (RPE) secretes several neurotrophic factors addressing diverse cellular pathways, potentially preserving photoreceptors. This study explored human embryonic stem cell-derived, polarized RPE soluble factors (PRPE-SF) as a combination treatment for retinal degeneration. PRPE-SF promoted retinal progenitor cell survival, reduced oxidative stress in ARPE-19 cells, and demonstrated critical antioxidant and anti-inflammatory effects for preventing retinal degeneration in the Royal College of Surgeons (RCS) rat model. Importantly, PRPE-SF treatment preserved retinal structure and scotopic b-wave amplitudes, suggesting therapeutic potential for delaying retinal degeneration. PRPE-SF is uniquely produced using biomimetic membranes for RPE polarization and maturation, promoting a protective RPE secretome phenotype. Additionally, PRPE-SF is produced without animal serum to avoid immunogenicity in future clinical development. Lastly, PRPE-SF is a combination of neurotrophic factors, potentially ameliorating multiple dysfunctions in retinal degenerations. In conclusion, PRPE-SF offers a promising therapeutic candidate for retinal degenerative diseases, advancing the development of effective therapeutic strategies for these debilitating conditions.
Mechanical and optical nanodevices in single-crystal quartz (2017)

Single-crystal α-quartz, one of the most widely used piezoelectric materials, has enabled a wide range of timing applications. Owing to the fact that an integrated thin-film based quartz platform is not available, most of these applications rely on macroscopic, bulk crystal-based devices. Here, we show that the Faraday cage angled-etching technique can be used to realize nanoscale electromechanical and photonic devices in quartz. Using this approach, we demonstrate quartz nanomechanical cantilevers and ring resonators featuring Qs of 4900 and 8900, respectively.
Dual targeting improves capture of ultrasound microbubbles towards activated platelets but yields no additional benefit for imaging of arterial thrombosis (2017)

Platelets can be found on the surface of inflamed and ruptured atherosclerotic plaques. Thus, targeting of activated platelets may allow for molecular imaging of vulnerable atherosclerotic lesions. We here investigated microbubbles (MB) functionalized with the selectin ligand sialyl Lewis<sup>a</sup> individually (MB<sub>sLea</sub>) or dually with sLe<sup>a</sup> and an antibody targeting ligand-induced binding sites of the activated GPIIb/IIIa receptor (MB<sub>Dual</sub>). Assessed by in vitro flow chamber, targeted MB exhibited increased adhesion to platelets as compared to MB<sub>Control</sub>. While MB<sub>sLea</sub> rolled slowly on the platelets' surface, MB<sub>Dual</sub> enhanced the percentage of firm adhesion. In vivo, MB were investigated by ultrasound in a model of ferric chloride induced non-occlusive carotid artery thrombosis. MB<sub>sLea</sub> and MB<sub>Dual</sub> revealed a higher ultrasound mean acoustic intensity than MB<sub>Control</sub> (p < 0.05), however MB<sub>Dual</sub> demonstrated no additional increase in mean signal intensity as compared to MB<sub>sLea</sub>. The degree of carotid artery stenosis on histology correlated well with the ultrasound acoustic intensity of targeted MB (p < 0.05). While dual targeting of MB using fast binding carbohydrate polymers and specific antibodies is a promising strategy to support adhesion to activated platelets under arterial shear stress, these advantages seem not readily translatable to in vivo models.
Hepatocyte Growth Factor Acts as a Motogen and Guidance Signal for Gonadotropin Hormone-Releasing Hormone-1 Neuronal Migration (2007)

Reproduction in mammals is under the control of the hypothalamic neuropeptide gonadotropin hormone-releasing hormone-1 (GnRH-1). GnRH-1-secreting neurons originate during embryonic development in the nasal placode and migrate into the forebrain along olfactory nerves. Gradients of secreted molecules may play a role in this migratory process. In this context, hepatocyte growth factor (HGF) is a potential candidate, because it promotes cell motility in developing brain and has been shown previously to act as a motogen on immortalized GnRH-1 neurons (GN11). In this study, the role of HGF and its receptor Met during development of the GnRH-1 system was examined. GnRH-1 cells express Met during their migration and downregulate its expression once they complete this process. Tissue-type plasminogen activator (tPA), a known HGF activator, is also detected in migratory GnRH-1 neurons. Consistent with in vivo expression, HGF is present in nasal explants, and GnRH-1 neurons express Met. HGF-neutralizing antibody was applied to explants to examine the role of the endogenous growth factor. Migration of GnRH-1 cells and olfactory axon outgrowth were significantly reduced, in line with disruption of a guidance gradient. Exogenous application of HGF to explants increased the distance that GnRH-1 cells migrated, suggesting that HGF also acts as a motogen to GnRH-1 neurons. Functional experiments, performed on organotypic slice cultures, show that creation of an opposing HGF gradient inhibits GnRH-1 neuronal migration. Finally, tPA(-/-):uPA(-/-) (urokinase-type plasminogen activator(-/-)) knock-out mice exhibit strong reduction of the GnRH-1 cell population. Together, these data indicate that HGF signaling via Met receptor influences the development of GnRH-1.
A Comparison of the Antinociceptive Properties of SJP-005 and Morphine in Rats (2021)

SJP-005 (a combination of ketotifen and ibuprofen) is being developed as a potential treatment for pain and for opioid use disorder. It is therefore important to investigate the potential antinociceptive properties of SJP-005. Two studies were conducted to evaluate the potential effects of SJP-005 in rats. Study 1 applied the von Frey test to examine the antinociceptive effect of morphine with and without SJP-005 in adjuvant-induced hypersensitivity to tactile stimulation. In a double-blind, between-groups design, groups of rats (<i>n</i> = 10 each) received morphine at 3, 10, or 30 mg/kg bodyweight (bw) (subcutaneous injection) with or without SJP-005 (oral). Mechanic allodynia and paw volume were assessed before and after treatment. Study 2 utilized the hot plate test. Using a crossover design, groups of rats (<i>n</i> = 10 each) received either morphine at 3, 10, or 30 mg/kg bw (subcutaneous injection) preceded by oral administration of placebo (Week 1) or SJP-005 (Week 2). In Study 1, in the von Frey up-and-down test, Δ paw withdrawal responses in Group 1 (3 mg/kg bw morphine) were significantly lower compared to those in Group 4 (3 mg/kg bw morphine plus SJP-005), whereas the differences in Δ paw withdrawal between Group 2 and Group 5 (10 mg/kg bw morphine with and without SJP-005) and between Group 3 and Group 6 (10 mg/kg bw morphine with and without SJP-005) did not reach statistical difference. Trendline analysis of the dose-response relationship for the morphine + placebo groups and morphine + SJP-005 groups revealed no significant differences in the intercepts and slopes. In Study 2, no significant differences were observed on hot plate performance between morphine and morphine in combination with SJP-005. In conclusion, the findings in the von Frey up-and-down test (Study 1) suggest that animals can withstand higher levels of painful stimuli when SJP-005 is co-administered. This may also suggest a possible opioid sparing effect. However, in the hot plate test (Study 2), animals did not respond more adaptively to stronger painful stimuli after co-administering SJP-005. These observations warrant further investigation of the antinociceptive properties of SJP-005.
ChemInform Abstract: Gas Phase Photoproduction of Diatomic Metal Nitrides During Metal Nitride Laser Chemical Vapor Deposition. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An Ionic Capacitor for Integrated Iontronic Circuits (2019)

Abstract Organic electronics, in combination with custom polyelectrolytes, enables solid‐ and hydrogel‐state circuit components using ionic charges in place of the electrons of traditional electronics. This growing field of iontronics leverages anion‐ and cation‐exchange membranes as analogs to n‐type and p‐type semiconductors, and conjugated polymer electrodes as ion‐to‐electron converters. To date, the iontronics toolbox includes ionic resistors, ionic diodes, ionic transistors, and analog and digital circuits comprised thereof. Here, an ionic capacitor based on mixed electron–ion conductors is demonstrated. The ionic capacitor resembles the structure of a conventional electrochemical capacitor that is inverted, with an electronically conducting core and two electrolyte ionic conductors. The device is first verified as a capacitor, and then demonstrated as a smoothing element in an iontronic diode bridge circuit driving an organic electronic ion pump (ionic resistor). The ionic capacitor complements the existing iontronics toolbox, enabling more complex and functional ionic circuits, and will thus have implications in a variety of mixed electron–ion conduction technologies.
Design and modeling challenges for DDR II memory subsystems (2003)

This paper describes the electrical packaging challenges, design issues, and design solutions for source-synchronous DDR II memory subsystems utilizing the double data rate (DDR) timing protocols. Major design and modeling issues are discussed, such as crosstalk, delay skew, impedance control and inter-symbol interference. The timing and jitter budgets, and the noise margin allocation for the various components of the optimization equations are discussed in conjunction with their associated design control techniques. A novel termination technique is discussed that allows for maximum memory capacity per channel at a given data rate.
Heterogeneity in X-linked recessive Charcot-Marie-Tooth neuropathy. (1991)

Three families presenting with X-linked recessive Charcot-Marie-Tooth neuropathies (CMT) were studied both clinically and genetically. The disease phenotype in family 1 was typical of CMT type 1, except for an infantile onset; two of five affected individuals were mentally retarded, and obligate-carrier females were unaffected. Families 2 and 3 showed distal atrophy with weakness, juvenile onset, and normal intelligence. Motor-nerve conduction velocities were significantly slowed, and electromyography data were consistent with denervation in affected CMT males in all three families. Thirty X-linked RFLPs were tested for linkage studies against the CMT disease loci. Family 1 showed tight linkage (recombination fraction [theta] = 0) to Xp22.2 markers DXS16, DXS143, and DXS43, with peak lod scores of 1.75, 1.78, and 2.04, respectively. A maximum lod score of 3.48 at DXS16 (theta = 0) was obtained by multipoint linkage analysis of the map DXS143-DXS16-DXS43. In families 2 and 3 there was suggestion of tight linkage (theta = 0) to Xq26 markers DXS86, DXS144, and DXS105, with peak lod scores of 2.29, 1.33, and 2.32, respectively. The combined maximum multipoint lod score of 1.81 at DXS144 (theta = 0) for these two families occurred in the map DXS10-DXS144-DXS51-DXS105-DXS15-DXS52++ +. A joint homogeneity analysis including both regions (Xp22.2 and Xq26-28) provided evidence against homogeneity (chi 2 = 9.12, P less than .005). No linkage to Xp11.12-q22 markers was observed, as was reported for X-linked dominant CMT and the Cowchock CMT variant. Also, the chromosomes 1 and 17 CMT loci were excluded by pairwise linkage analysis in all three families.
A Soft, Biocompatible Magnetic Field Enabled Wireless Surgical Lighting Patty for Neurosurgery (2020)

General surgical procedures are subject to low-light conditions or a narrow angle of view, and such limitations in light limit visibility and complicate the given surgical procedure. Conventional lighted surgical tools rely on an external light source, which may be oriented into a cavity or mounted on a surgical instrument such as retractor, endoscopes, or suction tubes. However, such conventional lighted instruments do not provide adequate lighting during various surgical procedures. Here, we present a soft, miniaturized magnetic-enabled wireless surgical lighting patty. Specifically, the proposed surgical lighting patty that can be temporarily implanted into a cavity or surgical corridor provides lighting to the surgical subject and manages fluids in a surgical field. The surgical lighting patty is a multilayer patty, two outer layers of the lighted surgical patty and the center lighted layer. A reed switch in the central layer can activate the power supply in response to a magnet to emit the light from the light source. The result allows a dramatically simplified wireless operation. Moreover, it can provide various wavelengths of light to a surgical field for purposes such as illuminating the surgeon’s field of vision, exciting dyes, and sterilizing surgical fields.
Rheology of Barium Sulfate Suspensions and Pre-thickened Beverages Used in Diagnosis and Treatment of Dysphagia (2007)

Abstract Pre-thickened beverages and barium sulfate suspensions are used in the treatment and diagnosis of dysphagia. These liquids are labeled nectar consistency (NC), honey consistency (HC) etc. These labels are rather misleading and do not represent the actual rheological character of the liquids. We carefully investigated the rheology of these liquids to assist both in their formulation and use for dysphagic patients. Steady state flow properties, thixotropy, dynamic response, and creep recovery behavior were investigated for six beverages and two barium sulfate suspensions. All samples exhibited a shear-thinning behavior. The flow curves of all samples followed both Herschel-Bulkley and Casson models. HC barium sulfate suspension exhibited higher yield stress, σ o , and higher storage modulus, G’ , than their fluid food counterparts. In contrast, NC barium sulfate suspension had lower σ o , and G’ than some of the liquid food counterparts. Frequency spectra of NC samples were similar to that of a macromolecular solution with both G’ and loss modulus, G’’ , increasing with frequency; whereas those of HC samples were similar to that of a gel with a little dependency of G’ and G’’ over frequency. Stress sweep experiments showed that the linear viscoelastic region of fluid foods and barium sulfate suspensions extended up to 1 and 10 Pa, respectively. Thus, significant differences exist in the rheological properties of both pre-thickened and videofluoroscopy fluids currently used for diagnosis and treatment of dysphagia.
Optimizing Retail Contracts for Electricity Markets (2007)

The Olympic Peninsula Testbed Demonstration in Washington State allowed residential electricity customers the choice of three different types of retail electricity rates; a time-of-use price, a fixed price, and a 5-minute real-time price. Each of these rates structures has advantages and disadvantages for both the residential consumers as well as the utility offering them. This paper focuses on a methodology to select the mix of rate types a utility should offer to its residential consumers given the various objectives it seeks to achieve. The method used to determine an optimal mix was borrowed from stock market portfolio theory and results in what is referred to as the Efficient Frontier. This solution defines an optimal mix of contract types among many possible combinations.
Percutaneous Management of Urolithiasis During Pregnancy (1992)

A total of 6 pregnant women with obstructing urinary calculi was managed by percutaneous nephrostomy drainage placed under ultrasound guidance with the patient under local anesthesia. All patients initially had relief of acute obstruction. However, occlusion of the percutaneous nephrostomy tubes with debris necessitated tube changes in 5 of 6 patients. In 2 patients recurrent nephrostomy tube obstruction, fever and pain led to percutaneous stone removal during pregnancy. In the remaining 4 patients the nephrostomy tubes were left indwelling through delivery. During the postpartum period 3 patients successfully underwent ureteroscopic stone extraction and 1 passed the stone spontaneously. Bacteriuria developed in each patient despite the use of preventive antibiotics. All 6 women had uncomplicated vaginal deliveries of healthy newborns and are currently asymptomatic with no evidence of obstruction. Percutaneous drainage of an acutely obstructed kidney in a pregnant woman is an effective temporizing alternative to ureteral stent placement until definitive treatment can be performed.
Optimization of a permeation‐based microfluidic direct formic acid fuel cell (DFAFC) (2011)

A design for a passive, air-breathing microfluidic fuel cell utilizing formic acid (FA) as a fuel is described and its performance characterized. The fuel cell integrates high surface area platinum (cathode) and palladium-platinum (anode) alloy electrodes within a PDMS microfluidic network that keeps them fully immersed in a liquid electrolyte. The polymer network that comprises the device also serves as a self-supporting membrane through which FA and oxygen are supplied to the alloy anode and cathode, respectively, by passive permeation from external sources. The cell is based on a planar form-factor and in its operation exploits FA concentration gradients that form across the PDMS membrane. These latter gradients allow the device to operate stably, producing a nearly constant limiting power density of ~0.2 mW/cm², without driven laminar flow of fluids or the incorporation of an in-channel separator between the anodic and the cathodic compartments. The power output of this elementary device in air is subject to electrolyte mass transport impacts, which can be reduced for a given design rule by decreasing the internal ohmic resistance of the cell. The results suggest that operational stability can be improved by decreasing the kinetic losses imposed on the cathode side of the cell due to FA crossover and modalities for doing so, such as by increasing the efficiency of fuel capture at the anode.
Controls Development for Clutch-Assisted Engine Starts in a Parallel Hybrid Electric Vehicle (2011)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;In a parallel hybrid electric vehicle, higher fuel economy gains are typically achieved if significant electric drive (or engine-off) operation is possible, shifting the engine operating schedule so that it only runs at medium to high load for best efficiency. To enable efficient engine-off driving, a typical configuration will have a disconnect clutch between the engine and the rest of the driveline. In some configurations, when engine-on operation is requested the disconnect clutch is applied in conjunction with the traction motor/generator to crank the engine (i.e., a flying engine start). In this paper we describe the development of a control system for a flying engine start using an engine disconnect clutch. The clutch is located between the engine and electric motor, which is connected to the input of a multispeed transmission. We first describe an initial control algorithm evaluation using a driveline model. After this initial evaluation, the control algorithm was incorporated into an existing hybrid vehicle control system architecture and tested on a HIL bench to validate code implementation. Finally, we describe experiments in which we tested the control algorithm in a test cell using a mule transmission. We discuss in qualitative terms the refinements in the control algorithm resulting from the experimental results.&lt;/div&gt;&lt;/div&gt;
A High-Power Density, Full-Bridge Parallel Load Resonant ZVZCS DC-DC Converter (2004)

A full-bridge parallel loaded resonant zero current/zero voltage switching converter is developed for DC-DC voltage transformation. The power supply was used to condition power sourced by a 28volt 400A Neihoff alternator installed in a HMMWV delivered to a 5-kilowatt mobile radar. This design focuses on achieving maximum power density at reasonable efficiency (i.e. > 80%) by operating at the highest resonant and switching frequencies possible. A resonant frequency of 392kHz was achieved while providing rated power. The high resonant frequency was facilitated by the development of an extremely low inductance layout (< 20nH) capable of conducting the high resonant currents associated with this converter topology.
QRS duration and cardiovascular mortality in Asian patients with heart failure and preserved and reduced ejection fraction (2020)

The QRS duration has been well established as a predictor of mortality in patients with heart failure with reduced ejection fraction (HFrEF) In patients with heart failure with preserved ejection fraction (HFpEF), some studies have shown that prolonged QRS duration has been associated with increased morbidity and mortality However, these studies were based mainly on Western cohorts with scarce data from Asia, where normal ranges for QRS duration may differ The aim of this study was to examine the association between QRS duration and mortality in an Asian heart failure cohort.
A study on effects of implicit and explicit language model information for DBLSTM-CTC based handwriting recognition (2015)

Deep Bidirectional Long Short-Term Memory (DBLSTM) with a Connectionist Temporal Classification (CTC) output layer has been established as one of the state-of-the-art solutions for handwriting recognition. It is well-known that the DBLSTM trained by using a CTC objective function will learn both local character image dependency for character modeling and long-range contextual dependency for implicit language modeling. In this paper, we study the effects of implicit and explicit language model information for DBLSTM-CTC based handwriting recognition by comparing the performance of using or without using an explicit language model in decoding. It is observed that even using one million lines of training sentences to train the DBLSTM, using an explicit language model is still helpful. To deal with such a large-scale training problem, a GPU-based training tool has been developed for CTC training of DBLSTM by using a mini-batch based epochwise Back Propagation Through Time (BPTT) algorithm.
[Study on the combination of preozonation and post-ozonation-BAC process for drinking water treatment]. (2005)

This study was conducted to illustrate the effectiveness of preozonation or O3-BAC or combination of these two process in controlling DBPs for treating a dam source water in South China through SBR and continuous flow (200 L/h) experiments and the variables in the treatment train included the point of preozonation with respect to coagulation; the point of ozonation with respect to BAC, the ozone dosage required for preozonation and the Br- content of raw water. Results indicated the reduction in DBP formation potential closely paralleled the reduction in UV absorbance, and trihalomethane and haloacetic acid formation potential can be removed under a dose of preozone at 0.5 - 1.0 mg/L, at the same time, ozone by-products (bromate and formaldehyde) can be controlled in low level. The continuous flow experiment results show that combination of preozonation and O3-BAC process has obviously positive effects on the removals of particles with a size above 2 microm, COD(Mn), and TOC. However, DBPs formation can be controlled by the removal of organic matters.