gebhart/patrepeval huggingface dataset:
General methods for .alpha.- or .beta.-O-Ser/Thr glycosides and glycopeptides. Solid-phase synthesis of O-glycosyl cyclic enkephalin analogs (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeneral methods for .alpha.- or .beta.-O-Ser/Thr glycosides and glycopeptides. Solid-phase synthesis of O-glycosyl cyclic enkephalin analogsRobin Polt, Lajos Szabo, Jennifer Treiberg, Yushun Li, and Victor J. HrubyCite this: J. Am. Chem. Soc. 1992, 114, 26, 10249–10258Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/ja00052a022https://doi.org/10.1021/ja00052a022research-articleACS PublicationsRequest reuse permissionsArticle Views999Altmetric-Citations103LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Load Model Data Tool (2013)

The LMDT software automates the process of the load composite model data preparation in the format supported by the major power system software vendors (GE and Siemens). Proper representation of the load composite model in power system dynamic analysis is very important. Software tools for power system simulation like GE PSLF and Siemens PSSE already include algorithms for the load composite modeling. However, these tools require that the input information on composite load to be provided in custom formats. Preparation of this data is time consuming and requires multiple manual operations. The LMDT software enables to automate this process. Software is designed to generate composite load model data. It uses the default load composition data, motor information, and bus information as an input. Software processes the input information and produces load composition model. Generated model can be stored in .dyd format supported by GE PSLF package or .dyr format supported by Siemens PSSE package.
Path planning strategies for laser line forming (2003)

Thermal-mechanical processing by laser radiation has been shown effective in forming plates into relatively complex shapes at economically supportable rates. While simulation models to predict deformation given a set of process parameters exist and continue to be improved, few attempts have been made to solve the so-called inverse problem. This inverse problem can be defined as determining the locations and processing parameters of the heating paths that will result in a desired deformation. The calculation of these heating paths is an under-constrained problem with essentially infinite potential solutions. Recent research efforts at several international institutions have provided various strategies for solving this problem. This paper discusses these strategies, as well as the most recent developments from the ongoing efforts at the Applied Research Laboratory and at the Department of Mechanical Engineering, both of Penn State University.
Fiber laser based hyperspectral sources (2008)

Hyperspectral sources spanning from the XUV to the THz spectral range based on high power ultrafast fiber lasers are reviewed. With advances in large core and micro-structured fibers as well as absolute phase control techniques fiber systems can greatly exceed the performance of solid-state lasers systems in the hyperspectral domain.
Fabrication and Electrochemical Performance of TiO2–TiN/Sn–SnO2 Composite Films on Ti for LIB Anodes with High Capacity and Excellent Conductivity (2022)

Abstract According to the requirements for anode materials of safe and high‐capacity lithium‐ion batteries (LIBs), various Sn/TiO 2 and SnO 2 /TiO 2 composite materials have been developed, but no reports have yet combined them by a simple fabrication method. Herein, a novel and simple approach is reported for the fabrication of nanoporous TiO 2 –TiN/Sn–SnO 2 composite films by successive Ti anodization and cathodic hybrid electrodeposition of Sn in a nitric acid‐based aqueous solution containing Sn 2+ and/or Sn 4+ ions. The conductivity of the anodic TiO 2 –TiN composite films facilitates the simultaneous electrodeposition of metallic Sn and electrophoretic deposition of SnO 2 colloids, both on the surface and inside the nanopores of the film. Notably, the nanoporous structure is preserved, which provides a large surface area. The electrodeposition of Sn–SnO 2 nanoparticles on the nanoporous TiO 2 –TiN film significantly improves the charge transfer and conductivity of the composite film and enhances the discharge capacity to up to 2386.1 µAh cm −2 (approximately sixfold higher than that of the bare matrix film).
Tumor suppressive activities of solvatochromic 3,3′‐azadimethylene dinaphthospiropyran in colon cancer model (2020)

Spiropyrans have been extensively investigated because of their thermo- and photochromic characteristics, but their biotherapeutic properties have not been explored much. We report anti-proliferative properties of a novel 3,3'-azadimethylene dinaphthospiropyran 11. Dibenzospiropyrans and dinaphthospiropyrans were synthesized by a simple and expedient method using acid-catalyzed aldol condensation of salicylaldehyde and 2-hydroxy-1-naphthaldehyde, respectively, with cyclic ketones. Together with structural elucidation by 2D NMR and X-ray crystallography studies, we provide a putative mechanism for their formation. Compound 11 showed solvatochromism and exhibited altered spectral characteristics depending on the pH. In acidic conditions, 11 remains in open form, whereas upon alkalinization it reverts back to closed form. Based on the in vitro anti-proliferative activity in H441, HCT-116, MiaPaCa-2, and Panc-1 cancer cell lines, 11 was submitted to further investigation. It reduced HCT116 colonosphere formation and demonstrated induction of caspase cascade, suggesting apoptosis. In vitro proliferation assays also suggested that HCl and trifluoroacetate salts of 11 are more effective. Treatment of mice carrying HCT-116 xenografts with 11 (5 µg/day, intraperitoneal for 3 weeks) suppressed tumor growth by 62%. Overall, the results reveal a new series of structurally complex, but relatively easy to synthesize molecules of which compound 11 represents a lead for anticancer development.
Polymers for Improving the In Vivo Transduction Efficiency of AAV2 Vectors (2010)

Our results show that the pre-injection of polymers can improve the overall transduction efficiency of systemically administered AAV2 and reduce the humoral response against the capsid proteins.
Optical Performance Monitoring of Phase-Modulated Signals Using Asynchronous Amplitude Histogram Analysis (2008)

As optical networks continue to grow towards high capacity and high flexibility, new transmission technologies are being introduced. In order to maintain the quality of signal and control over network in the transparent domains, optical performance monitoring (OPM) systems are becoming a necessity. Phase modulation formats emerge as the solution of choice in transparent domains because of their sensitivity, spectral efficiency, and resilience to optical impairments. In this paper, we demonstrate a flexible OPM method for phase-modulated signals using asynchronous amplitude histogram analysis. We show numerically and experimentally the monitoring of optical signal-to-noise ratio (OSNR), chromatic dispersion (CD), and polarization-mode dispersion (PMD) for differential phase-shift keying (DPSK) and differential quadrature phase-shift keying (DQPSK) signals. The OSNR can be measured within range of 20-35 dB and accumulated chromatic dispersion between 600 and 600 ps/nm. The asynchronous amplitude histogram monitoring method is proved to be a precise and versatile monitoring tool for high-capacity optical networks.
Modelling Novel Electrode Configurations for Nanosecond Pulsed Plasmas: A First Study (2018)

Determining the efficiency of various types of plasmas is a classical problem, particularly between DC, AC, and nanosecond repetitively pulsed plasmas (NRPPs). NRPPs have gained substantial traction because they can efficiently generate ionized and excited species at atmospheric pressure. While numerous studies have elucidated the impact of the local flow fields [1], understanding the in fluence of electrode geometry and the induced flow field remains incomplete. We hypothesize that the electrode configuration will strongly influence the electric field, plasma species, and the induced flow field. This motivates the development of a complete model coupling these phenomena.
Abstract 4540: Development of a biochemical High Throughput Screening (HTS) assay for chemical inhibitors of MALT1, a target for lymphoma therapeutics. (2013)

Abstract MALT1 plays critical role in antigen receptor-mediated lymphocyte activation and lymphomagenesis. MALT1 acts both as a scaffold protein to recruit upstream signal transducers and as an intracellular cysteine protease with proteolytic activity that cleaves substrate proteins involved in NF-kB induction. Dysregulation of MALT1 activity occurs in lymphoma as a result of chromosomal translocations that fuse the catalytic domain of MALT1 with portions of BirC3 (c-IAP2). Previous studies have shown that MALT1’s proteolytic activity is required for its participation in NF-kB induction and for promoting cell viability of certain types of lymphomas, particularly the activated B-cell (ABC) type of diffuse large B-cell lymphoma. To lay a foundation for discovery of drug-like chemical inhibitors of MALT1, we developed a fluorescence-based, biochemical assay for measuring protease activity of MALT1 in vitro in 384 and 1,536 well formats. The assay components included recombinant purified full-length MALT1 protein, the MALT1-binding protein, Bcl-10, and the fluorigenic substrate Ac-LRSR-AMC (Ac-Leu-Arg-Ser-Arg-7-amino-4-methylcoumarin). Experiments showed that addition of Bcl-10 increases MALT1‘s protease activity up to 20-40 fold. The high throughput screening (HTS) assay was validated with excellent Z’ factors (&amp;gt;0.7) in both 384 and 1,536 well formats, with performance remaining robust for more than 6 hours, and thus suitable for screening of large chemical libraries. The HTS assay was validated by performing pilot screens with two small collections of compounds enriched in bioactive molecules (n = 1280 for LopacTM and 2000 for SpectrumTM library), yielding confirmed hit rates of 0.2 % and 0.7%, respectively. Counter-screening assays were also generated using other types of intracellular cysteine proteases, specifically Caspase-3 and Autophagin-1 (ATG4B), for eliminating non-specific inhibitors. Various supporting cell-based assays have also been generated to support hit characterization. In conclusion, we have generated a robust biochemical HTS assays for detection of chemical inhibitors of the MALT1 protease. We plan to utilize the HTS assay for screening large compound libraries as a starting point for discovery of novel therapeutics for treatment of lymphoma, autoimmunity, and allograft rejection. Citation Format: Dayong Zhai, Chih-Wen Shu, Paul Diaz, John C. Reed. Development of a biochemical High Throughput Screening (HTS) assay for chemical inhibitors of MALT1, a target for lymphoma therapeutics. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4540. doi:10.1158/1538-7445.AM2013-4540
Enhanced sensitivity of an antibody competitive blocking enzyme-linked immunosorbent assay using Equine arteritis virus purified by anion-exchange membrane chromatography (2015)

In an effort to improve a competitive blocking enzyme-linked immunosorbent assay (cELISA) for antibody detection to Equine arteritis virus (EAV), antigen purified by anion-exchange membrane chromatography capsule (AEC) was evaluated. Virus purification by the AEC method was rapid and easily scalable. A comparison was made between virus purified by the AEC method with that obtained by differential centrifugation based on the following: 1) the relative purity and quality of EAV glycoprotein 5 (GP5) containing the epitope defined by monoclonal antibody 17B7, and 2) the relative sensitivity of a commercial antibody cELISA with the only change being the 2 purified antigens. On evaluation by Western blot using GP5-specific monoclonal antibody 17B7, the AEC-purified EAV contained 86% GP5 monomer whereas the differentially centrifuged EAV contained <29% of the monomer. Improvement of analytical sensitivity without sacrifice of analytical specificity was clearly evident when cELISAs prepared with EAV antigen by each purification method were evaluated using 7 sensitivity and specificity check sets. Furthermore, the AEC-purified EAV-based cELISA had 30-40% higher agreement with the virus neutralization (VN) test than the cELISA prepared with differentially centrifuged EAV based on testing 40 borderline EAV-seropositive samples as defined by the VN test. In addition, the AEC-purified cELISA had highly significant (P = 0.001) robustness indicated by intra-laboratory repeatability and interlaboratory reproducibility when evaluated with the sensitivity check sets. Thus, use of AEC-purified EAV in the cELISA should lead to closer harmonization of the cELISA with the World Organization for Animal Health-prescribed VN test.
Optical trapping of metal particles in doughnut-shaped beam emitted by photonic-crystal laser (2007)

Doughnut-shaped beams can trap low-index or non-transparent particles. It is demonstrated that a TEM01* mode beam emitted directly by a photonic-crystal (PC) laser can stably trap metal particles in two dimensions. Replacing a conventional Gaussian-beam laser with a PC laser overcomes the limits of conventional optical tweezers, thereby opening the way for novel applications.
A New High-Performance Four-Stroke Engine for All-Position Use in Hand-Held Power Tools (2004)

&lt;div class="htmlview paragraph"&gt;This paper reviews the current and new mini-four-stroke engine technologies that are suitable to be implemented in light-weight outdoor power equipment. A new mixture lubrication setup has been developed for a very compact mini-four-stroke engine.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Special emphasis is laid on the design of the combustion chamber and the valve train. The paper derives how to systematically translate the user demands of a light weight engine to the new mini-four-stroke engine. The new STIHL 4-MIX-engine features an integral one-component cylinder including the cylinder head, two valves and a very simple drive train consisting of a plastic cam including a decompression mechanism. The valve train stands speeds in excess of 12000 rpm and it is also lubricated by the new mixture lubrication setup. The piston is used as an oil-mist pump. The engine has an output of 1.0 kW out of 31.4 cm&lt;sup&gt;3&lt;/sup&gt;. Pressure indication work is used in order to optimize the combustion process.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The development effort and process of this new mini-four-stroke technology are very important and to a certain extent pioneering for the use of mini-four-stroke engines in all-position hand-held outdoor power equipment.&lt;/div&gt;
The optical and mechanical properties of Eu-doped Ca-α-SiAlON phosphor-SiO<sub>2</sub> composite films (2010)

The compaction of a SiAlON phosphor powder was performed by electrophoretic deposition (EPD). The SiAlON phosphor films were filled with SiO2 for improved adhesion to the glass substrate. The TEOS (tetraethoxysilane Si(OC2H5)4) or TEMOS (tetramethoxysilane Si(OCH3)4) sol-gel precursor was impregnated in the SiAlON deposited film, then thermally treated at 773 K. The optical and mechanical properties of the SiAlON phosphor-SiO2 composite films were also characterized.
Broadband 6-μm OPA driven by Yb:CaF 2 DPSSL system (2012)

6-μJ, 6-μm pulses compressible to 1.5 optical cycles are generated in multistage OPA driven by 500-Hz Yb:CaF2-DPSSL. The system is favorable for verification of the predictions on λ-scaling of photoelectron wavepacket dynamics and atmospheric spectroscopy.
The role of peptide-MHC ligand density in stimulating T-cell receptor signaling (58.21) (2012)

Abstract Cell surface MHC proteins form clusters on the cell membrane. The MHC density within clusters could affect recognition of noncognate (self) and cognate peptide-MHC (pMHC) ligands and influence the kinetics of TCR-mediate signaling and quality of T cell responses. To evaluate the role of density, orientation and valency of pMHC ligands we utilized different scaffolds to assemble pMHC oligomers modeling MHC clusters. We systematically investigated how these parameters influence the binding of the pMHC oligomers to live CD8+ cytotoxic T lymphocytes (CTL) and the kinetics of TCR-mediated signaling. We have found that the recognition of noncognate or self pMHC strongly depends on the pMHC density and architecture and size of the scaffolds. In contrast, the valency but not the pMHC density mostly determined the recognition of strong agonist pMHC ligands. In addition, the pMHC density significantly influences the ability of cognate and noncognate pMHC to cooperate and to induce robust and rapid TCR signaling. The latter regulates the kinetics of target cell destruction by CTL that is essential for successful anti-virus immunity.
New Quinoxaline Derivatives as Potential MT1 and MT2 Receptor Ligands (2012)

Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy group (or a bioisostere), linked to a central ring. Substitution of the indole ring found in melatonin with a naphthalene or quinoline ring leads to compounds of similar affinity. The next step in this structural approximation is to introduce a quinoxaline ring (a bioisostere of the quinoline and naphthalene rings) as the central nucleus of future melatoninergic ligands.
A Policy Description and Its Execution Scheduling for Automated IT Systems Management (2012)

Abstract In order to execute multiple policies in a policy‐based automation system safely and efficiently, we propose and develop a concurrency control mechanism for policy‐based automation systems. This mechanism analyzes the logical structure of the target application system to identify the IT resources affected by the policy action, and locks the resources to prevent conflicts between multiple policies. An efficient preemptive scheduling scheme for multiple policy executions is also developed. © 2012 Wiley Periodicals, Inc. Electron Comm Jpn, 95(9): 27–35, 2012; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/ecj.11399
A 1.2V 20 dBm 60 GHz power amplifier with 32.4 dB Gain and 20 % Peak PAE in 65nm CMOS (2014)

A 60 GHz highly linear Power Amplifier (PA) is implemented in 65-nm Low Power (LP) CMOS technology. The structure consists of four common-source pseudo-differential stages. To improve global performances, a compact transformer-based 8-way power combiner is designed. Three driver stages are neutralized with capacitors to enhance both reverse isolation and power gain. At 60 GHz, the PA delivers a saturated output power (P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">SAT</sub> ) of 19.9 dBm and a 1-dB compressed output power (P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1dB</sub> ) of 17.2 dBm while achieving maximum power added efficiency (PAE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</sub> ) of 20 %. The small-signal gain is about 33 dB with a 3-dB bandwidth of 9 GHz. The circuit occupies an active area of 0.32 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . To the author's knowledge, this amplifier presents the highest figure of merit (FoM ITRS) among 60 GHz PAs using silicon technology.
Stimulatory Role for Brain Serotoninergic System on Prolactin Secretion in the Male Rat (1976)

Systemic administration of parachlorophenylalanine (PCPA, 100 mg/kg sc on alternate days X two times), a blocker of serotonin (5-HT) synthesis, considerably decreased brain 5-HT and plasma prolactin (PRL) levels in young male rats. Intraventricular (IVT) administration of 5,7-dihydroxytryptamine (5,7-DHT, 200 mug/20 mul), a neurotoxic drug which destroys 5-HT nerve terminals, induced, 3, 12, and 30 days after treatment, a marked depletion of brain 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) and considerably reduced plasma PRL levels at each time interval. Feeding of rat for up to 4 days with a tryptophan (TP)-deficient diet, caused a depletion of brain 5-HT and 5-HIAA contents and did not modify plasma PRL levels. Addition of TP (2 g/kg of diet) to the TP-deficient diet resulted in increased brain 5-HT and 5-HIAA contents and significantly increased PRL levels. These data provide evidence for the role of the 5-HT system in the maintenance of tonic PRL secretion.
An efficient coordinated checkpointing scheme for multicomputers (2002)

A new approach for checkpointing multicomputer applications is presented. The checkpointing is initiated and controlled by a checkpoint coordinator, residing either on one of the nodes running the application or on the host processor attached to the multicomputer. A message count is used to determine if any messages are in transit. The proposed strategy is hardware-independent and can be implemented in any multicomputer system irrespective of the architecture, interconnection, and routing strategy. This scheme can be used for FIFO and non-FIFO channels as well as with channels where messages can be lost. Measurement results obtained from our simulations indicate that the proposed strategy outperforms an existing scheme proposed for fixed-path wormhole-routed multicomputer systems. Although the proposed strategy is targeted for high-performance, massively parallel multicomputers, it can also be used in any general-purpose distributed system to improve the checkpointing overhead.