gebhart/patrepeval huggingface dataset:
An improvement to multiple description transform coding (2002)

A multiple description transform coding (MDTC) method has been reported previously. The redundancy rate distortion (RRD) performance of this coding scheme for the independent and identically distributed (i.i.d.) two-dimensional (2-D) Gaussian source has been analyzed using mean squared error (MSE) as the distortion measure. At the small redundancy region, the MDTC scheme can achieve excellent RRD performance because a small increase in redundancy can reduce the single description distortion at a rate faster than exponential, but the performance of MDTC becomes increasingly poor at larger redundancies. This paper describes a generalization of the MDTC (GMDTC) scheme, which introduces redundancy both by transform and through correcting the error resulting from a single description. Its RRD performance is closer to the theoretical bound in the entire range of redundancy. Analysis both for a single pair of variables and for multiple variables is presented.
Predictors of Left Ventricular Remodelling in Patients with Dilated Cardiomyopathy – A Cardiovascular Magnetic Resonance Study (2020)

Substantial recovery of LV function occurs within 12 months in most patients with recent-onset DCM. Women had the greatest improvement in LVEF. A low LV contractile reserve measured by dobutamine stress CMR appears to identify patients whose LVEF is less likely to recover.
Surface modification of polytetrafluoroethylene filmsvia graft copolymerization for auto-adhesion (1998)

The surfaces of Ar plasma-pretreated polytetrafluoroethylene (PTFE) films are further functionalized via UV-induced graft copolymerization with amphoteric N,N′-dimethyl(methacryloylethyl)ammonium propansulfonate (DMAPS) either in Ar atmosphere, or under atmospheric conditions and in the absence of a polymerization initiator. The so-modified PTFE films from either process are capable of exhibiting adhesive-free adhesion or auto-adhesion with one another when brought into intimate contact in the presence of a small quantity of water. The lap shear adhesion strength increases with increasing graft concentration and can readily exceed the yield strength of the PTFE substrate. Two plasma-pretreated PTFE films also readily undergo thermal graft copolymerization with concurrent lamination when lapped together in the presence of a small quantity of the DMAPS monomer solution at elevated temperature in the atmosphere. The surface compositions of the graft-copolymerized PTFE films and the delaminated surfaces were characterized by X-ray photoelectron spectroscopy (XPS). In most cases, adhesional failure occurred near the graft-substrate interphase. © 1998 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 36: 3107–3114, 1998
PET/CT Imaging and Human Papilloma Virus–Positive Oropharyngeal Squamous Cell Cancer: Evolving Clinical Imaging Paradigm (2014)

Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) represents an emerging disease that differs from HPV-negative OPSCC in natural history and prognosis. Contrast-enhanced PET/CT is essential to accurately stage the primary site when there are smaller tumors; neck nodal metastases, which tend to have a more cystic component; and distant metastases that manifest in unusual sites (disseminating phenotype) such as bones and other solid organs, including brain. Metastases tend to appear later in the disease course during follow-up for HPV-positive OPSCC than for HPV-negative OPSCC. Because HPV-positive OPSCC patients have a better clinical outcome, there is a need for treatment deintensification to spare the patient from treatment-related toxicities. (18)F-FDG PET/CT would play a role in monitoring patients with deintensified treatments to ensure that no adverse outcome is introduced. The better prognosis and outcome of HPV-positive OPSCC patients would warrant imaging follow-up that is less intense but continues longer because of the manifestation of distant metastases later in the disease course and at unusual sites. All these clinical paradigms facilitate a definite role for PET/CT imaging in the management of HPV-positive OPSCC.
Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas (2023)

Homozygous deletion of CDKN2A/B was recently incorporated into the World Health Organization classification for grade 3 meningiomas. While this marker is overall rare in meningiomas, its relationship to other CDKN2A alterations on a transcriptomic, epigenomic, and copy number level has not yet been determined. We therefore utilized multidimensional molecular data of 1577 meningioma samples from 6 independent cohorts enriched for clinically aggressive meningiomas to comprehensively interrogate the spectrum of CDKN2A alterations through DNA methylation, copy number variation, transcriptomics, and proteomics using an integrated molecular approach. Homozygous CDKN2A/B deletions were identified in only 7.1% of cases but were associated with significantly poorer outcomes compared to tumors without these deletions. Heterozygous CDKN2A/B deletions were identified in 2.6% of cases and had similarly poor outcomes as those with homozygous deletions. Among tumors with intact CDKN2A/B (without a homozygous or heterozygous deletion), we found a distinct difference in outcome based on mRNA expression of CDKN2A, with meningiomas that had elevated mRNA expression (CDKN2A<sup>high</sup>) having a significantly shorter time to recurrence. The expression of CDKN2A was independently prognostic after accounting for copy number loss and consistently increased with WHO grade and more aggressive molecular and methylation groups irrespective of cohort. Despite the discordant and mutually exclusive status of the CDKN2A gene in these groups, both CDKN2A<sup>high</sup> meningiomas and meningiomas with CDKN2A deletions were enriched for similar cell cycle pathways but at different checkpoints. High mRNA expression of CDKN2A was also associated with gene hypermethylation, Rb-deficiency, and lack of response to CDK inhibition. p16 immunohistochemistry could not reliably differentiate between meningiomas with and without CDKN2A deletions but appeared to correlate better with mRNA expression. These findings support the role of CDKN2A mRNA expression as a biomarker of clinically aggressive meningiomas with potential therapeutic implications.
Electrical Properties of Solid-State Nanopore Sensors (2003)

Abstract : This final report documents support from ONR in developing a solid state single molecule sensor. The sensor uses a voltage biased nanopore in an insulating membrane that separates two pools of conducting salt water. The biased nanopore attracts and translocates charged biopolymers like DNA. The ionic current that flows through the pore is sensitive to the presence of single molecules and can be used to measure their passage. In this work we demonstrate the process using solid state pores for the first time.
Signal-on Protein Detection via Dye Translocation between Aptamer and Quantum Dot (2016)

A unique interaction between the cyanine dye and negatively charged quantum dot is used to construct a signal-on biaptameric quantum dot (QD) Förster resonance energy transfer (FRET) beacon for protein detection and distinct aptamer characterization. The beacon comprises a pair of aptamers, one intercalated with the cyanine dye (YOYO-3) and the other conjugated to a negatively charged, carboxyl-QD. When the target protein is present, structural folding and sandwich association of the two aptamers take place. As a consequence, YOYO-3 is displaced from the folded aptamer and transferred to the unblocked QD surface to yield a target concentration-dependent FRET signal. As a proof-of-principle, we demonstrate the detection of thrombin ranging from nanomolar to submicromolar concentrations and confirm the dye translocation using cylindrical illumination confocal spectroscopy (CICS). The proposed beacon provides a simple, rapid, signal-on FRET detection for protein as well as a potential platform for distinct aptamer screening.
Quality of service and system design (2003)

Quality of Service (QoS) of the implementation of an application can be defined as a function of the properties of the application and its implementation as observed by the user and/or the environment. Typical application and implementation properties include latency, throughput, jitter and the level of resolution. Many of the current and pending most popular applications, such as multimedia, wireless sensing and communications, security and PEBBs, have intrinsic relevant QoS components. Recently quality of service attracted a great of deal of attention in a number of research and development communities, and in particular in the network and multimedia literature. However, until now synthesis and CAD research did not addressed how to design systems with quantitative QoS requirements. Our goal in this paper is to outline foundations and framework in which QoS system design trade-offs and optimization can be addressed. We first identify and state in synthesis-usable way two currently most popular approaches to Quality of Service treatment: Q-RAM and DS-curve (demand/service). We discuss advantages and limitations of the two approaches. Next, we show how these two approaches can be combined in a new more comprehensive QoS framework. We also explain and illustrate using examples interaction between QoS and synthesis and compilation tasks. We conclude by identifying and discussing the future directions related to synthesis of QoS-sensitive systems.
Anti-Jamming Performance of Spectrally Shaped Generalized MC-DS-SS with Dual Band Combining (2006)

The anti-jamming performance of a spectrally shaped multicarrier spread spectrum modulation scheme is investigated in this paper. The spectral shaping of the multicarrier spread spectrum signal is accomplished via the use of sinusoidal chip waveforms. As a result, the transmitted energy is transmitted via two sidebands. Specifically, one half of the energy is transmitted through a lower sideband (LSB), and the other half through an upper sideband (USB). Since the jammer can only put its energy at some portion of the whole bandwidth, these two independent sideband signals, when combined at the receiver, improve the anti-jam performance of the system. We illustrate this via comparing with conventional MC-DS-SS, and show our scheme's superior performance
Direct Measurements of Self-Sputtering, Swelling, and Deposition Effects of N-Type Low-Energy Ion Implantations (2009)

Angle-resolved X-ray photoelectron spectroscopy method was used to study self-sputtering effects of different n-type low-energy doping techniques, including conventional monoatomic <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">75</sup> As and <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">31</sup> P beam-line ion implants and AsH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> plasma doping (PLAD). It has been found that the self-sputtering effects of the beam-line implants correlate with the mass of ion species. As beam-line implant shows more serious self-sputtering effect than monoatomic P and B beam-line implants. Very low energy P implants show surface-swelling phenomena. PLAD process using AsH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> gas species has no sputtering effects but has slight deposition under current process condition.
Pulmonary Vein Isolation With a Novel Multielectrode Radiofrequency Balloon Catheter That Allows Directionally Tailored Energy Delivery (2019)

URL: https://www.clinicaltrials.gov. Unique identifier: ISRCTN 11764506.
The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer (2019)

Kallikrein-related peptidase 14 (KLK14) is one of the several secreted KLK serine proteases involved in prostate cancer (PCa) pathogenesis. While relatively understudied, recent reports have identified KLK14 as overexpressed during PCa development. However, the modulation of KLK14 expression during PCa progression and the molecular and biological functions of this protease in the prostate tumor microenvironment remain unknown. To determine the modulation of KLK14 expression during PCa progression, we analyzed the expression levels of KLK14 in patient samples using publicly available databases and immunohistochemistry. In order to delineate the molecular mechanisms involving KLK14 in PCa progression, we integrated proteomic, transcriptomic, and in vitro assays with the goal to identify substrates, related-signaling pathways, and functional roles of this protease. We showed that KLK14 expression is elevated in advanced PCa, and particularly in metastasis. Additionally, KLK14 levels were found to be decreased in PCa tissues from patients responsive to neoadjuvant therapy compared to untreated patients. Furthermore, we also identified that KLK14 expression reoccurred in patients who developed castrate-resistant PCa. The combination of proteomic and transcriptomic analysis as well as functional assays revealed several new KLK14 substrates (agrin, desmoglein 2, vitronectin, laminins) and KLK14-regulated genes (Interleukin 32, midkine, SRY-Box 9), particularly an involvement of the mitogen-activated protein kinase 1 and interleukin 1 receptor pathways, and an involvement of KLK14 in the regulation of cellular migration, supporting its involvement in aggressive features of PCa progression. In conclusion, our work showed that KLK14 expression is associated with the development of aggressive PCa suggesting that targeting this protease could offer a novel route to limit the progression of prostate tumors. Additional work is necessary to determine the benefits and implications of targeting/cotargeting KLK14 in PCa as well as to determine the potential use of KLK14 expression as a predictor of PCa aggressiveness or response to treatment.
Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase deficiency (2019)

Triosephosphate isomerase (TPI) deficiency is a fatal genetic disorder characterized by hemolytic anemia and neurological dysfunction. Although the enzyme defect in TPI was discovered in the 1960s, the exact etiology of the disease is still debated. Some aspects indicate the disease could be caused by insufficient enzyme activity, whereas other observations indicate it could be a protein misfolding disease with tissue-specific differences in TPI activity. We generated a mouse model in which exchange of a conserved catalytic amino acid residue (isoleucine to valine, Ile170Val) reduces TPI specific activity without affecting the stability of the protein dimer. TPI<sup>Ile170Val/Ile170Val</sup> mice exhibit an approximately 85% reduction in TPI activity consistently across all examined tissues, which is a stronger average, but more consistent, activity decline than observed in patients or symptomatic mouse models that carry structural defect mutant alleles. While monitoring protein expression levels revealed no evidence for protein instability, metabolite quantification indicated that glycolysis is affected by the active site mutation. TPI<sup>Ile170Val/Ile170Val</sup> mice develop normally and show none of the disease symptoms associated with TPI deficiency. Therefore, without the stability defect that affects TPI activity in a tissue-specific manner, a strong decline in TPI catalytic activity is not sufficient to explain the pathological onset of TPI deficiency.
Low-temperature growth of highly crystalline β-Ga2O3 nanowires by solid-source chemical vapor deposition (2014)

77.55.D; 61.46.Km; 78.40.Fy.
Multi-View Reconstruction and Camera Recovery using a Real or Virtual Reference Plane; PHD THESIS (2003)

Reconstructing a 3-dimensional scene from a set of 2-dimensional images is a fundamental problem in computer vision. A system capable of performing this task can be used in many applications in robotics, architecture, archaeology, biometrics, human computer interaction and the movie and entertainment industry. Most existing reconstruction approaches exploit one source of information to tackle the problem. This is the motion of the camera, the 2D images are taken from different viewpoints. We exploit an additional information source, the reference plane, which makes it possible to reconstruct difficult scenes where other methods fail. A real scene plane may serve as the reference plane. Furthermore, there are many alternative techniques to obtain virtual reference planes. For instance, orthogonal directions in the scene provide a virtual reference plane, the plane at infinity, or images taken with a parallel projection camera. A collection of known and novel reference plane scenarios is presented in this thesis. The main contribution of the thesis is a novel multi-view reconstruction approach using a reference plane. The technique is applicable to three different feature types, points, lines and planes. The novelty of our approach is that all cameras and all features (off the reference plane) are reconstructed simultaneously from a single linear system of image measurements. It is based on the novel observation that cameras and features have a linear relationship if a reference plane is known. In the absence of a reference plane, this relationship is non-linear. Thus many previous methods must reconstruct features and cameras sequentially. Another class of methods, popular in the literature, is factorization, but, in contrast to our approach, this has the serious practical drawback that all features are required to be visible in all views. Extensive experiments show that our approach is superior to all previously suggested reference plane and non-reference plane methods for difficult reference plane scenarios. Furthermore, the thesis studies scenes which do not have a unique reconstruction, so-called critical configurations. It is proven that in the presence of a reference plane the set of critical configurations is small.  Finally, the thesis introduces a complete, automatic multi-view reconstruction system based on the reference plane approach. The input data is a set of images and the output a 3D point reconstruction together with the corresponding cameras.
Superior mechanical and optical properties of a heterogeneous library of cross-linked biomimetic self-assembling peptides (2020)

Self-assembling peptides (SAP) are ideal components for biomedical devices. However, their practical applications have been limited due to their intrinsic unstable, low-performance, and low-stress response given by non-covalent interactions involved in self-assembling. Herein, a library of SAPs featuring different self-assembled nanostructures was successfully cross-linked with genipin, allowing to produce nanofibrous hydrogels with enhanced mechanical properties (G′ ≥ 0.2 MPa, stress-failure ≥ 3.5 kPa) and enhanced thermostability (≥100 °C) while maintaining their native nanoarchitecture. Cross-linking dramatically changed the optical properties of SAPs: it triggered new absorption/fluorescence bands in the visible spectral range, which are attributed to charge transfer between peptide chains. Genipin cross-linking, fitted for different classes of SAPs, could be a powerful tool to obtain biomimetic SAP scaffolds with tunable stiffness and thermostability. Lastly, because of the changed absorption/emission properties and relaxation kinetics of cross-linked SAPs, genipin cross-linking may bestow novel optical properties to several well-known lysine-containing SAPs, with intriguing potential for biomedical imaging, photonics and optoelectronics.
Myasthenia Gravis Treated With Autologous Hematopoietic Stem Cell Transplantation (2016)

Autologous HSCT results in long-term symptom- and treatment-free remission in patients with severe MG. The application of autologous HSCT for this and other autoimmune neurologic conditions warrants prospective study.
Improving the Understanding of Industrial Microbial Robustness with Systems Biology Tools (2010)

We have developed an ontology, OncoCL, to classify cancer cells and provide a framework for consistent annotation of cancer-associated data from conventional surgical pathology and cancer molecular biology for the purpose of access, comparison, and analysis. The cell type ontology, CL, describes normal cell types and was not designed to capture the pathology of cancer cells. OncoCL builds upon CL, as a canonical cell (represented in CL) undergoes oncogenic change and tumorigenesis with the acquisition of the cancer hallmarks described by Hanahan and Weinberg.
A 30 V complementary bipolar technology on SOI for high speed precision analog circuits (2002)

A complementary bipolar technology with full dielectric isolation merges 30 V capable polyemitter NPN and PNP transistors with capacitors, polysilicon resistors, Schottky diodes, and fuses. A 6000 V//spl mu/s slew rate, 400 MHz bandwidth current feedback operational amplifier has been implemented in this technology.
Reactive single-step hot-pressing and magnetocaloric performance of polycrystalline Fe2Al1.15−xB2GexGax (x = 0, 0.05) MAB phases (2023)

Reactive single-step hot-pressing at 1473 K and 35 MPa for 4 h produces dense, bulk, near single-phase, low-cost, and low-criticality Fe2Al1.15B2 and Fe2Al1.1B2Ge0.05Ga0.05 MAB samples, showing second-order magnetic phase transition with favorable magnetocaloric properties around room temperature. The magnetic as well as the magnetocaloric properties can be tailored upon Ge and Ga doping, leading to an increase in the Curie temperature TC and the spontaneous magnetization mS. The maximum isothermal entropy change ΔsT,max of hot-pressed Fe2Al1.15B2 in magnetic field changes of 2 and 5 T amounts to 2.5 and 5 J(kgK)−1 at 287.5 K and increases by Ge and Ga addition to 3.1 and 6.2 J(kgK)−1 at 306.5 K, respectively. The directly measured maximum adiabatic temperature change ΔTad,max is improved by composition modification from 0.9 to 1.1 K in magnetic field changes of 1.93 T. Overall, we demonstrate that hot-pressing provides a much faster, more scalable, and processing costs reducing alternative compared to conventional synthesis routes to produce heat exchangers for magnetic cooling devices. Therefore, our criticality assessment shows that hot-pressed Fe-based MAB phases provide a promising compromise of material and processing costs, criticality, and magnetocaloric performance, demonstrating the potential for low-cost and low-criticality magnetocaloric applications around room temperature.
Dilute versus concentrated vasopressin administration during laparoscopic myomectomy: a randomised controlled trial (2016)

This randomised trial failed to show benefit of high-volume dilute vasopression.
Using chemistry to reconstruct evolution: On the origins of fish-hunting in venomous cone snails (2007)

CHEMICAL COMPOUNDS derived from living organisms are similar to non-biological substances in that their composition and structure can be characterized, and many can be directly synthesized by standard chemical methods. However, biological compounds are fundamentally different in that each has an underlying evolutionary history. We describe several compounds from an unusual source, the venoms of fish-hunting cone snails. The chemical characterization of some toxins from these venoms has unexpectedly revealed how fish-hunting may have originated in cone snails, and suggests that piscivory may have evolved independently multiple times in these venomous predators. Fish-hunting marine snails would appear to be a most improbable product of evolution. These snails devour fish as their major prey; a priori, fish would be expected to easily elude capture, simply by swimming out of the reach of the snails. However, a significant fraction of the �500 venomous cone snail species (genus Conus) have evolved to become specialized fish-hunters (Röckel et al. 1995). Cone snails spear their fish prey with a hollow, harpoon-shaped tooth that jets out from a long distensible proboscis; this functions as