gebhart/patrepeval huggingface dataset:
Smart phone use by non-mobile business users (2011)

The rapid increase in smart phone capabilities has introduced new opportunities for mobile information access and computing. However, smart phone use may still be constrained by both device affordances and work environments. To understand how current business users employ smart phones and to identify opportunities for improving business smart phone use, we conducted two studies of actual and perceived performance of standard work tasks. Our studies involved 243 smart phone users from a large corporation. We intentionally chose users who primarily work with desktops and laptops, as these "non-mobile" users represent the largest population of business users. Our results go beyond the general intuition that smart phones are better for consuming than producing information: we provide concrete measurements that show how fast reading is on phones and how much slower and more effortful text entry is on phones than on computers. We also demonstrate that security mechanisms are a significant barrier to wider business smart phone use. We offer design suggestions to overcome these barriers.
Analysis of high-Q photonic crystal L3 nanocavities designed by visualization of the leaky components (2017)

We experimentally study photonic crystal L3 nanocavities whose design Q factors (Q<sub>design</sub>) have been improved with the visualization of leaky components design method. The experimental Q values (Q<sub>exp</sub>) are monotonically increased from 6,000 to 2,100,000 by iteratively modifying the positions of some of the air holes, as determined by the referred design method. We investigate the Q<sub>exp</sub> tolerance to imperfections in the fabricated samples, which reveals that the cavities improved by the visualization method tend to lose some tolerance to structural differences between the fabricated samples and the design values.
ChemInform Abstract: Pyrazolopyrimidines as Highly Potent and Selective, ATP‐Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR): Optimization of the 1‐Substituent. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Analysis of the Tau-Associated Proteome Reveals That Exchange of Hsp70 for Hsp90 Is Involved in Tau Degradation (2012)

The microtubule associated protein tau (MAPT/tau) aberrantly accumulates in 15 neurodegenerative diseases, termed tauopathies. One way to treat tauopathies may be to accelerate tau clearance, but the molecular mechanisms governing tau stability are not yet clear. We recently identified chemical probes that markedly accelerate the clearance of tau in cellular and animal models. In the current study, we used one of these probes in combination with immunoprecipitation and mass spectrometry to identify 48 proteins whose association with tau changes during the first 10 min after treatment. These proteins included known modifiers of tau proteotoxicity, such as ILF-2 (NFAT), ILF-3, and ataxin-2. A striking observation from the data set was that tau binding to heat shock protein 70 (Hsp70) decreased, whereas binding to Hsp90 significantly increased. Both chaperones have been linked to tau homeostasis, but their mechanisms have not been established. Using peptide arrays and binding assays, we found that Hsp70 and Hsp90 appeared to compete for binding to shared sites on tau. Further, the Hsp90-bound complex proved to be important in initiating tau clearance in cells. These results suggest that the relative levels of Hsp70 and Hsp90 may help determine whether tau is retained or degraded. Consistent with this model, analysis of reported microarray expression data from Alzheimer's disease patients and age-matched controls showed that the levels of Hsp90 are reduced in the diseased hippocampus. These studies suggest that Hsp70 and Hsp90 work together to coordinate tau homeostasis.
Tunable external cavity laser with a stationary deformable MEMS grating (2004)

A tunable external cavity laser is demonstrated which uses a deformable MEMS grating as the tuning element. Unlike conventional systems, it has no mechanical motion except for the deformation of the MEMS grating surface.
CMOS-Integrated Low-Noise Germanium Waveguide Avalanche Photodetector Operating at 40Gbps (2010)

Germanium waveguide avalanche photodiode with 10dB gain and excess noise factor with keff below 0.2 was demonstrated. Gain-bandwidth-product above 350GHz was achieved at voltages around 3V. The avalanche photodetector was monolithically integrated into front-end CMOS.
Low-profile antenna for Bluetooth® and dual-band Wi-Fi coexistence in wireless access points (2016)

This paper proposes a planar antenna which enables Bluetooth and dual-band Wi-Fi coexistence in wireless communication access points. The proposed antenna has one 5G and two 2.4G ports with very high isolation between 2G and 5G ports as well as highly decoupled 2.4G Wi-Fi and Bluetooth ports.
Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration (2020)

Our results suggest that a higher CSF sTREM2 levels are associated with attenuated ApoE4-related risk for future cognitive decline and AD-typical neurodegeneration. These findings provide further evidence that TREM2 may be protective against the development of AD.
ANFIS based Coordination of Multiple UPFC Control Functions for Damping Low Frequency Oscillations in Power Systems (2009)

Multiple controllers perform the control functions of unified power flow controller (UPFC) to exploit its various functional capabilities. Due to dynamic interactions among different UPFC controllers, performance is deteriorated when separately designed and individually implemented stable UPFC controllers are in joint operation. An adaptive neuro-fuzzy inference system (ANFIS) based supplementary unified power flow controller (UPFC) in co-ordination with other controllers of the UPFC to damp the low frequency oscillations is proposed in this paper. A hybrid learning procedure was adopted for the proposed ANFIS to adapt the gains of the damping controller over wide range of operating conditions, various control signals and in presence of different UPFC controllers. The input to the fuzzy controller was the deviation in the generator angular speed and output, the control signal to be superimposed on the selected UPFC signal. The performance of the proposed adaptive damping controller was validated by time domain simulation under varying operating conditions, system parameters and in presence of other UPFC controllers.
Dual-Energy CBCT Pre-Spectral-Decomposition Filtering with Wavelet Shrinkage Networks (2020)

Convolutional Neural Networks (CNNs) are reshaping signal processing and computer vision by providing data-driven solutions for inverse problems such as noise reduction. However, their relationship with established signal processing methods is sometimes unclear and its development not fully exploiting the existing knowledge. In this paper, rather than improving existing CNNs with wavelet transformations as explored earlier, we improve the wavelet shrinkage approach to noise-reduction with a data-driven solution. The resulting CNN has clear encoding, decoding and processing paths. As application, we perform noise reduction in Dual-Energy Cone- Beam CT. The obtained results were compared to a UNet-like architecture, which reveal better noise-free images without aliasing artifacts. This indicates that that our architecture is able to preserve well the information contained in the images because the architecture exploits explicitly the underlying signal representation.
Discovery of the First Series of Inhibitors of Human Papillomavirus Type 11: Inhibition of the Assembly of the E1—E2—Origin DNA Complex (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Phase Change Disk Media Having Rapid Cooling Structure (1989)

It is found that a rapid cooling structure is effective to improve overwrite characteristics of phase change type optical disk media. For a rapid cooling structure, thin A1N dielectric layer, 30 nm, with high thermal conductivity is suitable. The layer is adopted between the active layer and the reflective metal layer in quadrilayer disk structure. The cooling rate of the disk is calculated to be 12°C/nsec. This disk structure shows clear amorphous marks. A thin active layer disk structure using GeTe–Sb 2 Te 3 –Sb ,alloy of 20 nm has produced two million cycle stable bit error rate characteristics. 1) And the erasability of the disk having a rapid cooling structure goes up more than 30 dB and shows rather wide plateau region of power dependency.
Glow‐discharge‐induced graft polymerization of acrylic acid onto poly[1‐(trimethylsilyl)‐1‐propyne] film (1991)

Abstract Graft polymerization of acrylic acid onto poly[1‐(trimethylsilyl)‐1‐propyne] [poly(TMSP)] film was examined. The water contact angle of poly(TMSP) film decreased remarkably from 90 to 15° by plasma treatment, which gradually increased up to 40° after several days. When the film exposed to a glow discharge was heated in an aqueous solution of acrylic acid at 80°C for 24 h, graft polymerization proceeded on the film surface, which was confirmed by ATR‐IR and ESCA spectra. Graft polymerization effectively occurred above a threshold temperature (80°C). The water contact angle of the grafted film was about 30°, and did not change with time. In contrast, when a poly(TMSP) film exposed to UV irradiation was heated in an aqueous solution of acrylic acid, graft polymerization took place not only on the film surface but also inside the film.
Resource management in single-chip multiprocessors (2005)

Technology advances will soon enable billion transistor chips, permitting large quantities of both logic and memory to be placed on a single die. Increasing on-chip wire delays, however, are shrinking the chip area reachable in a single clock cycle. In response, computer architects are redesigning on-chip structures to reduce the distance signals must travel in one clock period. Single-chip multiprocessors are one proposed architecture for dealing with the multi-cycle communication latencies affecting future chips. These chips are organized into a grid of nodes, where each node contains a processor and a portion of the total on-chip memory. Although these nodes function independently, they interact via shared memory through a network with the property that latency increases linearly based on Manhattan distance. 
This dissertation examines how to efficiently map applications onto single-chip multiprocessors given these chips' constraints and opportunities. The small amount of per-node storage limits how much data can be placed on any given node, while the ample processing resources and high bandwidth, low-latency on-chip communication create a large number of quickly accessible locations where data and threads can reside. In order to achieve high performance on these chips, applications must balance the competing goals of improving locality and of distributing resource demands across the chips' many nodes. I present two symbiotic approaches for managing these chips' resources. The first technique, migration of data and threads, reacts to dynamic resource demands and communication patterns to avoid resource hot-spotting and improve locality. The second approach proactively eliminates communication by executing computation at the location of its most frequently accessed data, its anchor. Finally, I show how these techniques can be used in conjunction with well-established techniques, like caching, to further improve application performance.
A qualitative description of the transverse motion of axial channeled particles in thin crystals (1972)

Abstract The qualitative features of the angular distribution of particles emergent from thin ∼ 1μ, uniform single crystals of silicon and germanium for incidence at small angles to axial directions are discussed in terms of the continuum picture of particle channeling. Blocking of axially channeled particles in the transverse plane is demonstrated. Implications and possibilities arising from observation of non-equilibrium of the transverse momentum vector are discussed. The use of the radial spreading of the angular distribution to investigate the average inter-atomic potential distribution in the plane transverse to the axial direction is explored and perturbations due to multiple scattering in surface films or inside the crystal and to beam divergence are qualitatively considered.
Microstructure-sensitive modeling of the macroscopic behavior of ad730 nickel-based polycrystalline superalloy using crystal plasticity finite element simulations (2019)

International audience
LET‐23‐mediated signal transduction during Caenorhabditis elegans development (1995)

We are using Caenorhabditis elegans vulval induction to study intercellular signaling and its regulation. Genes required for vulval induction include the LIN-3 transforming alpha-like growth factor, the LET-23 epidermal growth factor (EGF)-receptor-like transmembrane tyrosine kinase, the SEM-5 adaptor protein, LET-60 Ras, and the LIN-45 Raf serine/threonine kinase. Inactivation of this pathway results in a failure of vulval differentiation, the "vulvaless" phenotype. Activation of this pathway either by overexpression of LIN-3, a point mutation in the LET-23 extracellular domain, or hyperactivity of LET-60 Ras results in excessive vulval differentiation, the "multivulva" phenotype. In addition to searching for new genes that act positively in this signaling pathway, we have also characterized genes that negatively regulate this inductive signaling pathway. We find that such negative regulators are functionally redundant: mutation of only one of these negative regulators has no effect on vulval differentiation; however, if particular combinations of these genes are inactivated, excessive vulval differentiation occurs. The LIN-15 locus encodes two functionally redundant products, LIN-15A and LIN-15B, that formally act upstream of the LET-23 receptor to prevent its activity in the absence of inductive signal. The LIN-15A and B proteins are novel and unrelated to each other. The unc-101, sli-1, and rok-1 genes encode a distinct set of negative regulators of vulval differentiation. The unc-101 gene encodes an adaptin, proposed to be involved in intracellular protein trafficking. The sli-1 gene encodes a protein with similarity to c-cbl, a mammalian proto-oncogene not previously linked with a tyrosine kinase-Ras-mediated signaling pathway. LIN-3 and LET-23 are required for several aspects of C. elegans development--larval viability, P12 neuroectoblast specification, hermaphrodite vulval induction and fertility, and three inductions during male copulatory spicule development. Fertility and vulval differentiation appear to be mediated by distinct parts of the cytoplasmic tail of LET-23, and by distinct signal transduction pathways.
Renal Metastasis of Adenocarcinoma of the Lung: Massive Hematuria Managed by Therapeutic Embolization (1979)

The rare complication of massive hematuria secondary to metastatic infiltrating adenocarcinoma of the lung to the kidney was managed with steel coil therapeutic embolization. The angiographic and pathologic picture as well as the advantages of this therapeutic modality in this clinical setting are discussed.
Neue Terphenylchinone aus Mycelkulturen von Punctularia atropurpurascens (Basidiomycetes) / New Terphenylquinones from Mycelial Cultures of Punctularia atropurpurascens (Basidiomycetes) (1984)

Abstract Three violet terphenylquinone pigments, 4′-hydroxyphlebiarubrone (2), 4′,4″-dihydroxy-phlebiarubrone (3), 3′,4′,4″-trihydroxyphlebiarubrone (4), and the already known pigment phlebiarubrone (1) were isolated from cultures of Punctularia atropurpurascens. The structures of the phlebiarubrone derivatives were determined by spectral evidence. The structure of 3 was confirmed by synthesis from atromentin (6). Two strains of the genus Punctularia obtained from CBS, were also found to produce these compounds, whereas with a third strain only the production of 1 was observed. 3 did not exhibit any antimicrobial or cytotoxic activity. The other pigments showed weak antibacterial and cytotoxic activity.
Peripheral T‐cell and NK cell lymphoproliferative disorders: cell of origin, clinical and pathological implications (2014)

T-cell lymphoproliferative disorders are a heterogeneous group of neoplasms with distinct clinical-biological properties. The normal cellular counterpart of these processes has been postulated based on functional and immunophenotypic analyses. However, T lymphocytes have been proven to be remarkably capable of modulating their properties, adapting their function in relationship with multiple stimuli and to the microenvironment. This impressive plasticity is determined by the equilibrium among a pool of transcription factors and by DNA chromatin regulators. It is now proven that the acquisition of specific genomic defects leads to the enforcement/activation of distinct pathways, which ultimately alter the preferential activation of defined regulators, forcing the neoplastic cells to acquire features and phenotypes distant from their original fate. Thus, dissecting the landscape of the genetic defects and their functional consequences in T-cell neoplasms is critical not only to pinpoint the origin of these tumors but also to define innovative mechanisms to re-adjust an unbalanced state to which the tumor cells have become addicted and make them vulnerable to therapies and targetable by the immune system. In our review, we briefly describe the pathological and clinical aspects of the T-cell lymphoma subtypes as well as NK-cell lymphomas and then focus on the current understanding of their pathogenesis and the implications on diagnosis and treatment.
Dual-tuning IPT Systems for Low Bandwidth Communications (2007)

This paper presents the design, implementation and performance of a low bandwidth physical communications channel for both new and existing inductive (contact-less) power transfer (IPT) applications, wherein power is transferred in the frequency range of 10 kHz to 50 kHz. The designed communications system operates at around 500 kHz without limiting power transfer, thereby maintaining the advantageous characteristics of IPT systems. The properties of the communications channel can be determined using the same magnetic coupling theory as applied for the power transfer. Its bandwidth is designed for control applications and is capable of up to 19.2 kbps. The channel was installed and evaluated on an existing electronic factory automation IPT system. Mathematical analysis of the channel resulted in a calculated path attenuation of 37 dB which compares favorably with practical measurements of typically 34 dB. When a real IPT power supply is present, harmonics of the power transfer frequency exist at the communications frequency and as such the communications channel utilizes a number of passive parallel and series tuned filters to maintain a signal to noise ratio of at least 10 dB.
High contrast 3D imaging of surfaces near the wavelength limit using tabletop EUV ptychography (2015)

Scanning electron microscopy and atomic force microscopy are well-established techniques for imaging surfaces with nanometer resolution. Here we demonstrate a complementary and powerful approach based on tabletop extreme-ultraviolet ptychography that enables quantitative full field imaging with higher contrast than other techniques, and with compositional and topographical information. Using a high numerical aperture reflection-mode microscope illuminated by a tabletop 30 nm high harmonic source, we retrieve high quality, high contrast, full field images with 40 nm by 80 nm lateral resolution (≈1.3 λ), with a total exposure time of less than 1 min. Finally, quantitative phase information enables surface profilometry with ultra-high, 6 Å axial resolution. In the future, this work will enable dynamic imaging of functioning nanosystems with unprecedented combined spatial (<10 nm) and temporal (<10 fs) resolution, in thick opaque samples, with elemental, chemical and magnetic sensitivity.
A large scale study of wireless search behavior (2006)

We present a large scale study of search patterns on Google's mobile search interface. Our goal is to understand the current state of wireless search by analyzing over 1 Million hits to Google's mobile search sites. Our study also includes the examination of search queries and the general categories under which they fall. We follow users throughout multiple interactions to determine search behavior; we estimate how long they spend inputting a query, viewing the search results, and how often they click on a search result. We also compare and contrast search patterns between 12-key keypad phones (cellphones), phones with QWERTY keyboards (PDAs) and conventional computers.
2-Nitro-1,3-indandione (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2-Nitro-1,3-indandioneB. E. Christensen, C. H. Wang, I. W. Davies, and Darrell HarrisCite this: Anal. Chem. 1949, 21, 12, 1573–1575Publication Date (Print):December 1, 1949Publication History Published online1 May 2002Published inissue 1 December 1949https://pubs.acs.org/doi/10.1021/ac60036a045https://doi.org/10.1021/ac60036a045research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer (2014)

The CAS/imp-α1 transport cycle is linked to XIAP and is required to maintain tumor cell survival in HCC. Moreover, CAS and imp-α1 are targets of p53-mediated repression, which represents a novel aspect of p53's ability to control tumor cell growth in hepatocarcinogenesis.
Eyelid Lacerations Secondary to Caesarean Section Delivery (2011)

A 32-week-gestation female was delivered emergently via caesarian section to a mother in premature labor due to placental abruption. On delivery, the neonate was noted to have sustained right upper and lower eyelid full-thickness lacerations extending from the medial canthal area with associated right upper and lower full-thickness canalicular lacerations. The neonate underwent same-day surgical repair of her eyelid lacerations with stenting of her canalicular system with a Crawford tube. At 2 months postoperatively, the child is opening her right upper eyelid without any signs of deprivation ambylopia. This case demonstrates the need to inform expectant mothers of the intrinsic risks of periorbital trauma during the birthing process that may result in visual loss through either ambylopia and/or globe injury.