gebhart/patrepeval huggingface dataset:
Cystic Fibrosis Gene Mutation (ΔF 508 ) Is Associated with an Intrinsic Abnormality in Ca 2+ -Induced Arachidonic Acid Release by Epithelial Cells (1997)

The mechanism(s) of chronic airway inflammation in cystic fibrosis (CF) remains poorly understood. We studied Ca2+-induced release of arachidonic acid (AA), a precursor of proinflammatory lipid mediators, in epithelial cell lines with the deltaF508 mutation in CF transmembrane conductance regulator (CFTR) gene and in those lacking this mutation or cells in which this mutation was corrected by a functional CFTR gene transfer. We found that: (i) the mutant cells manifested an abnormally high Ca2+-induced AA release as compared to controls, (ii) AA release appeared to be catalyzed by a phospholipase A2 (PLA2) but not by phospholipase C followed by diacylglycerol lipase, and (iii) either correction of the CFTR-mutation or inhibition of PLA2 activity rectified this AA release abnormality. Taken together, our results suggest that CFTR mutation is associated with an intrinsic abnormality in AA release by epithelial cells carrying the deltaF508 mutation and suggest that the mechanism of chronic airway inflammation in CF, at least in part, involves this abnormality. These results also partly explain the effectiveness of high-dose ibuprofen therapy in arresting the progression of destructive lung disease in CF. Furthermore, they raise the possibility that correction of abnormal AA release by inhibiting PLA2 activity may improve the therapeutic benefits of ibuprofen.
Dopamine-dependent synaptic plasticity in striatum during in vivo development (2001)

The neurotransmitters dopamine (DA) and glutamate in the striatum play key roles in movement and cognition, and they are implicated in disorders of the basal ganglia such as Parkinson's disease. Excitatory synapses in striatum undergo a form of developmental plasticity characterized by a decrease in glutamate release probability. Here we demonstrate that this form of synaptic plasticity is DA and DA D2 receptor dependent. Analysis of spontaneous synaptic responses indicates that a presynaptic mechanism involving inhibition of neurotransmitter release underlies the developmental plasticity. We suggest that a major role of DA in the striatum is to initiate mechanisms that regulate the efficacy of excitatory striatal synapses, producing a decrease in glutamate release.
A new alkaloid antibiotic tetrazomine structure determination. (1991)

A new alkaloid antibiotic tetrazomine was isolated from the culture broth of Saccharothrix mutabilis subsp. chichijimaensis subsp. nov., and its structure was determined to be I by means of spectroscopic measurements. It has an unusual structure which consists of six rings, including piperidine, piperazine, oxazole, and pyrrolidine rings.
Spatial Prediction Under Location Uncertainty In Cellular Networks (2015)

Coverage optimization is an important process for the operator as it is a crucial prerequisite towards offering a satisfactory quality of service to the end-users. The first step of this process is coverage prediction, which can be performed by interpolating geo-located measurements reported to the network by mobile users' equipments. In previous works, we proposed a low complexity coverage prediction algorithm based on the adaptation of the Geo-statistics Fixed Rank Kriging (FRK) algorithm. We supposed that the geo-location information reported with the radio measurements was perfect, which is not the case in reality. In this paper, we study the impact of location uncertainty on the coverage prediction accuracy and we extend the previously proposed algorithm to include geo-location error in the prediction model. We validate the proposed algorithm using both simulated and real field measurements. The FRK extended to take into account the location uncertainty proves to enhance the prediction accuracy while keeping a reasonable computational complexity.
ChemInform Abstract: 14‐Step Synthesis of (+)‐Ingenol from (+)‐3‐Carene. (2014)

Abstract The efficient, highly stereocontrolled title synthesis of (+)‐ingenol (I) uses a two‐phase (cyclase phase, oxidase phase/rearrangement) design.
ChemInform Abstract: Partial Molar Volumes, Expansibilities, and Compressibilities of . alpha.,ω‐Aminocarboxylic Acids in Aqueous Solutions Between 18 and 55 °C (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Material instabilities in the TaOx-based resistive switching devices (Invited) (2023)

Oxide-based resistive switching devices offer an attractive set of characteristics for embedded memories and neuromorphic computing. However, their endurance is limited with the origin of failure mechanisms not firmly established. Transmission electron microscopy results on <tex>$\text{TiN}/\text{TaO}_{\mathrm{x}}/\text{TiN}$</tex> structures suggest that the primary reason is the intrinsic instability of <tex>$\text{TaO}_{\mathrm{x}}$</tex> in the middle of the composition range. This material separates into Ta- and O-rich phases that affect the filament morphology and can result in either stuck-in-high or stuck-in-low resistance state failure. An additional factor affecting endurance of switching devices is the interdiffusion at the electrode-functional oxide interfaces.
Clearing the Skies over Modular Polyketide Synthases (2006)

Modular polyketide synthases (PKSs) are large multifunctional proteins that synthesize complex polyketide metabolites in microbial cells. A series of recent studies confirm the close protein structural relationship between catalytic domains in the type I mammalian fatty acid synthase (FAS) and the basic synthase unit of the modular PKS. They also establish a remarkable similarity in the overall organization of the type I FAS and the PKS module. This information provides important new conclusions about catalytic domain architecture, function, and molecular recognition that are essential for future efforts to engineer useful polyketide metabolites with valuable biological activities.
Novel High-Speed Turbo Compressor With Integrated Inverter for Fuel Cell Air Supply (2021)

Fuel cell technology is continuously gaining ground in E-mobility applications. Fuel cells require a constant supply of pressurized air, for which high-speed turbo compressors with air bearings are an optimal choice to reduce size, guarantee oil-free operation required for the lifetime of the fuel cell, and increase efficiency. However, the inverter driving the electric motor of the turbo compressor does not scale down with increasing speed; therefore, other technology advances are required to achieve an overall compressor system with low weight. New power electronic topologies (double-bridge voltage sources inverter), cutting edge power semiconductor technology (gallium nitride), and multiobjective optimization techniques allow reducing the inverter size, increasing inverter efficiency, and improving the output current quality and in return lowering the losses in the electric motor. This enables the electrical, mechanical, and thermal integration of the inverter into the compressor housing of very high-speed and compact turbo compressors, thereby reducing the size and weight of the overall compressor system by a factor of two. Furthermore, a turbo compressor with an integrated inverter reduces complexity and cost for operators with savings in casing, cables, coolant piping, and connectors and reduces EMI noise by shielding the high-frequency motor currents with one housing. Beside its main application for fuel cell air supply, the advantages gained by an integrated inverter can also be used in other boosting and air handling applications such as advanced air and exhaust handling in combustion engines. The proposed integration concept is verified with a 280,000 rpm, 1 kW turbo compressor, targeted for the Balance of Plant (BoP) of a 5–15 kW fuel cell. The experimental results show that the temperature limits on the power electronics parts can be kept below the limit of 90 °C up to a coolant temperature of 55 °C, and beside the advantage of lower cabling effort, the efficiency of the compressor system (turbo compressor and integrated inverter) is increased by 5.5% compared to a turbo compressor without an integrated inverter.
Human respiration rate estimation using body-worn ultra-wideband radar (2007)

This paper demonstrates the use of UWB radar in non-contact monitoring of respiration rates. Based on the proposed propagation model, it was shown that the delay information of the first echo conveys useful information on the breathing signal. Critical system design parameters have been identified through a sinusoidal approximation of the antenna heights. With a simple signal processing algorithm, it was verified via simulation that the respiration rate could be accurately measured for very low SNR values. Specifically, the influence of human body/cloth movements on the estimation accuracy is investigated. In future, we will be looking into the potential of employing such a system for heart beat detection.
Reliability and Initial Validation of the Ulcerative Colitis Endoscopic Index of Severity (2013)

The UCEIS and its components show satisfactory intrainvestigator and interinvestigator reliability. Among investigators, the UCEIS accounted for a median of 86% of the variability in evaluation of overall severity on the VAS when assessing the endoscopic severity of UC and was unaffected by knowledge of clinical details.
Iron catalysed thermal and photochemical oxidation of arsenic(III) (2002)

Arsenic redox reactions and mobility The mobility of arsenic, one the most prevalent natural pollutants in groundwater systems, is largely determined by its redox state. As(III) is generally more mobile in the aqueous environment than As(V). Due to the slow redox kinetics, arsenic is often not in redox equilibrium with the environment. Despite of their importance, the rather complex redox kinetics are poorly understood. We have investigated the role of dissolved iron and of Fe(III)(hydr)oxides in the oxidation of As(III) in the dark and in sunlit waters with kinetic and spectroscopic methods. Results and Discussion When reduced groundwater containing Fe(II) and As(III) comes into contact with air or aerated water, dissolved O2 leads to partial oxidation of As(III) in parallel to the oxidation of Fe(II). The As(III) is apparently oxidised by reactive oxygen species (O2 , H2O2, OH) and/or by higher-valent iron species, which are formed as intermediates during the oxidation of Fe(II). The forming Fe(III)(hydr)oxide colloids influence the reaction by adsorbing As(V) and As(III) and by catalysing the decomposition of H2O2. In water exposed to sunlight, UV-A radiation leads to photochemical oxidation of As(III) by photolysis of Fe(III) complexes, which produces Fe(II) and reactive oxygen species. Naturally occurring or added organic ligands, such as citrate, form Fe(III)-complexes which are photolysed efficiently, with quantum yields of 0.11.0. With light, As(III) can be readily oxidized even in the presence of only catalytic amounts of iron, with iron cycled between Fe(II) and Fe(III) by photoreduction and by oxidation with O2. Conclusions Redox reactions of arsenic are closely tied to the redox reactions of iron. The importance of the different reaction pathways can be estimated with kinetic models based on detailed reaction schemes.
Millisecond timescale reactions observed via X-ray spectroscopy in a 3D microfabricated fused silica mixer. Corrigendum (2022)

A figure in the article by Huyke et al. [(2021), J. Synchrotron Rad. 28, 1100-1113] is corrected.
Interaction of adjacent primase domains within the hexameric gene 4 helicase-primase of bacteriophage T7 (2002)

The interaction of primase monomers within the hexameric gene 4 helicase-primase of bacteriophage T7 has been examined by using two genetically distinct gene 4 proteins. The T7 56-kDa gene 4 protein differs from the full-length 63-kDa protein in that it lacks the N-terminal zinc motif essential for the recognition of primase recognition sites. A second gene 4 protein, gp4-K122A, is unable to catalyze the synthesis of phosphodiester bonds as the result of an amino acid change in the catalytic site. Although each protein alone is inactive, the two together catalyze the synthesis of RNA primers. Reconstitution of activity depends on hexamer formation. We propose that the zinc motif of one subunit in the hexamer interacts with the catalytic sites of adjacent subunits.
Nucleotide sequence of the restriction fragment Hind F - Eco RI2 of SV40 DNA (1977)

The nucleotide sequence of the SV40 genome region between the Hind K fragment and the Eco RI cleavage site has been determined by a combination of three different approaches : analysis of RNA products obtained by transcription with Escherichia coli DNA dependent RNA polymerase, partial degradations with snake venom exonuclease and base-specific chemical degradation of 5'-terminal labeled restriction fragments. This nucleotide sequence shows only one open reading frame and allows the deduction of a small segment of the amino acid sequence of VP1, the major structural protein.
Synthese carbocyclischer Carben-Komplexe durch metallinduzierte Diazocyclopentadien-Fragmentierung (1978)

Der erste Metallkomplex, der ein oligocyclisches Dicarben enthält, bildet sich dank einer bisher nicht beobachteten [2+2]-Cycloaddition des aus (1) freigesetzten Carbens. Die Struktur von (2) ist durch Röntgen-Strukturanalyse gesichert.
Fast And Accurate Reconstruction Of Transmural Activation Maps From Standard 12-lead ECG Using An Eikonal Model (2019)

International audience
The fate of human malignant melanoma cells transplanted into zebrafish embryos: Assessment of migration and cell division in the absence of tumor formation (2005)

Certain aggressive melanoma cell lines exhibit a dedifferentiated phenotype, expressing genes that are characteristic of various cell types including endothelial, neural, and stem cells. Moreover, we have shown that aggressive melanoma cells can participate in neovascularization in vivo and vasculogenic mimicry in vitro, demonstrating that these cells respond to microenvironmental cues and manifest developmental plasticity. To explore this plasticity further, we transplanted human metastatic melanoma cells into zebrafish blastula-stage embryos and monitored their behavior post-transplantation. The data show that human metastatic melanoma cells placed in the zebrafish embryo survive, exhibit motility, and divide. The melanoma cells do not form tumors nor integrate into host organs, but instead become scattered throughout the embryo in interstitial spaces, reflecting the dedifferentiated state of the cancer cells. In contrast to the fate of melanoma cells, human melanocytes transplanted into zebrafish embryos most frequently become distributed to their normal microenvironment of the skin, revealing that the zebrafish embryo contains possible homing cues that can be interpreted by normal human cells. Finally, we show that within the zebrafish embryo, metastatic melanoma cells retain their dedifferentiated phenotype. These results demonstrate the utility of the zebrafish embryonic model for the study of tumor cell plasticity and suggest that this experimental paradigm can be a powerful one in which to investigate tumor-microenvironment interactions.
Modeling TCP-vegas under on/off traffic (2003)

There has been a significant amount of research toward modeling variants of the Transmission Control Protocol (TCP) in order to understand the impact of this protocol on file transmission times and network utilization. Analytical models have emerged as a way to reduce the time required for evaluation when compared with more traditional evaluations performed using event driven simulators such as ns. In addition, when designed carefully, analytical models help researchers make design decisions about novel TCP mechanisms.
Human kidney amiloride-binding protein: cDNA structure and functional expression. (1990)

Phenamil, an analog of amiloride, is a potent blocker of the epithelial Na+ channel. It has been used to purify the porcine kidney amiloride-binding protein. Synthetic oligonucleotides derived from partial sequences have been used to screen a human kidney cDNA library and to isolate the cDNA encoding the human amiloride-binding protein. The primary structure was deduced from the DNA sequence analysis. The protein is 713 residues long, with a 19-amino acid signal peptide. The mRNA was expressed in 293-S and NIH 3T3 cells, yielding a glycoprotein (i) that binds amiloride and amiloride analogs with affinities similar to the amiloride receptor associated with the apical Na+ channel in pig kidney membranes and (ii) that is immunoprecipitated with monoclonal antibodies raised against pig kidney amiloride-binding protein.
Devices, Materials, and Processes for Nanoelectronics: Characterization with Advanced X‐Ray Techniques Using Lab‐Based and Synchrotron Radiation Sources (2011)

Abstract Future nanoelectronics manufacturing at extraordinary length scales, new device structures, and advanced materials will provide challenges to process development and engineering but also to process control and physical failure analysis. Advanced X‐ray techniques, using lab systems and synchrotron radiation sources, will play a key role for the characterization of thin films, nanostructures, surfaces, and interfaces. The development of advanced X‐ray techniques and tools will reduce risk and time for the introduction of new technologies. Eventually, time‐to‐market for new products will be reduced by the timely implementation of the best techniques for process development and process control. The development and use of advanced methods at synchrotron radiation sources will be increasingly important, particularly for research and development in the field of advanced processes and new materials but also for the development of new X‐ray components and procedures. The application of advanced X‐ray techniques, in‐line, in out‐of‐fab analytical labs and at synchrotron radiation sources, for research, development, and manufacturing in the nanoelectronics industry is reviewed. The focus of this paper is on the study of nanoscale device and on‐chip interconnect materials, and materials for 3D IC integration as well.
A pliable index coding approach to data shuffling (2017)

A promising area that has recently emerged, is on how to use index coding to improve the communication efficiency in distributed computing systems, especially for data shuffling in iterative computations. In this paper, we posit that pliable index coding can offer a more efficient framework for data shuffling, as it can better leverage the many possible shuffling choices to reduce the number of transmissions. We theoretically analyze pliable index coding under data shuffling constraints, and design an hierarchical data-shuffling scheme that uses pliable index coding as a component. We find transmission benefits up to O(ns/m) over index coding, where ns/m is the average number of workers caching a message, and m, n, and s are the numbers of messages, workers, and cache size, respectively.
Simulation of Simultaneous Tracking/Data Signal Detection Using Novel Aperture-Mounted Surface Recording Head (2002)

Recently, near-field surface recording based on near-field optical principles has been vigorously studied for higher data storage density. In near-field optics which utilizes an aperture, in addition to the high spatial resolution property, there is another characteristic that the shape of the optical spot can be arbitrarily controlled by the aperture configuration, and its application to various technologies in the optical disk drive is possible. From this perspective, we propose a novel tracking method utilizing an asymmetric configured aperture head which could provide continuous signal of readout data and tracking error simultaneously, and analyze its data read-out and tracking detection performance through the three-dimensional finite-difference time-domain (3D-FDTD) method. Our simulations reveal that this novel tracking head has sufficient data readout performance and high tracking sensitivity, and has the potential to readout both a data signal and a tracking signal simultaneously.
IEEE POCO 2015 Brings Fun and Education to Glasgow [Conference Reports] (2015)

peer-reviewed
Seeding Atomic Layer Deposition of High-k Dielectrics on Epitaxial Graphene with Organic Self-Assembled Monolayers (2011)

The development of high-performance graphene-based nanoelectronics requires the integration of ultrathin and pinhole-free high-k dielectric films with graphene at the wafer scale. Here, we demonstrate that self-assembled monolayers of perylene-3,4,9,10-tetracarboxylic dianhydride (PTCDA) act as effective organic seeding layers for atomic layer deposition (ALD) of HfO(2) and Al(2)O(3) on epitaxial graphene on SiC(0001). The PTCDA is deposited via sublimation in ultrahigh vacuum and shown to be highly ordered with low defect density by molecular-resolution scanning tunneling microscopy. Whereas identical ALD conditions lead to incomplete and rough dielectric deposition on bare graphene, the chemical functionality provided by the PTCDA seeding layer yields highly uniform and conformal films. The morphology and chemistry of the dielectric films are characterized by atomic force microscopy, ellipsometry, cross-sectional scanning electron microscopy, and X-ray photoelectron spectroscopy, while high-resolution X-ray reflectivity measurements indicate that the underlying graphene remains intact following ALD. Using the PTCDA seeding layer, metal-oxide-graphene capacitors fabricated with a 3 nm Al(2)O(3) and 10 nm HfO(2) dielectric stack show high capacitance values of ∼700 nF/cm(2) and low leakage currents of ∼5 × 10(-9) A/cm(2) at 1 V applied bias. These results demonstrate the viability of sublimated organic self-assembled monolayers as seeding layers for high-k dielectric films in graphene-based nanoelectronics.