gebhart/patrepeval huggingface dataset:
Mechanical Loading Reduces Inflammation-Induced Human Osteocyte-to-Osteoclast Communication (2015)

Multiple factors contribute to bone loss in inflammatory diseases such as rheumatoid arthritis (RA), but circulating inflammatory factors and immobilization play a crucial role. Mechanical loading prevents bone loss in the general population, but the effects of mechanical loading in patients with RA are less clear. Therefore, we aimed to investigate whether mechanical stimuli reverse the stimulatory effect of RA serum on osteocyte-to-osteoclast communication. Human primary osteocytes were pretreated with 10 % RA serum or healthy control serum for 7 days, followed by 1 h ± mechanical loading by pulsating fluid flow (PFF). Nitric oxide (NO) and prostaglandin E2 were measured in the medium. Receptor activator of nuclear factor-kappaB ligand (RANKL), osteoprotegerin (OPG), interleukin-6 (IL-6), cyclooxygenase-2 (COX2), matrix-extracellular phosphoglycoprotein (MEPE), cysteine-rich protein 61 (CYR61), and SOST gene expression was quantified by qPCR. Osteoclast precursors were cultured with PFF-conditioned medium (PFF-CM) or static-conditioned medium (stat-CM), and osteoclast formation was assessed. RA serum alone did not affect IL-6, CYR61, COX2, MEPE, or SOST gene expression in osteocytes. However, RA serum enhanced the RANKL/OPG expression ratio by 3.4-fold, while PFF nullified this effect. PFF enhanced NO production to the same extent in control serum (2.6-3.5-fold) and RA serum-pretreated (2.7-3.6-fold) osteocytes. Stat-CM from RA serum-pretreated osteocytes enhanced osteoclastogenesis compared with stat-CM from control serum-pretreated osteocytes, while PFF nullified this effect. In conclusion, RA serum, containing inflammatory factors, did not alter the intrinsic capacity of osteocytes to sense mechanical stimuli, but upregulated osteocyte-to-osteoclast communication. Mechanical loading nullified this upregulation, suggesting that mechanical stimuli could contribute to the prevention of osteoporosis in inflammatory disease.
Simulation of the Thermal Laser Separation Process (TLS) in Relation to the Crack Propagation at the Wafer Edge (2017)

Thermal Laser Separation (TLS) is a kerfless wafer dicing technology. This method uses thermal stress to propagate a crack through the substrate. An often noticed vulnerability of this procedure is a crack deviation at the end of the wafer [1]. This study shows a transient opto-thermal FE simulation model. The model allows a prediction of the cracking tip. Thus it is possible to identify the reason for the crack deviations. This approach allows a comparison of different parameters at the wafer edge. Different velocity profiles, beam shapes, laser and cooling powers were manipulated and these calculated results were compared with the experimental measurements of the crack deviation at the wafer edge.
High precision, medium flux rate CZT spectroscopy for coherent scatter imaging (2016)

CZT detectors are primary candidates for many next-generation X-ray imaging systems. These detectors are typically operated in either a high precision, low flux spectroscopy mode or a low precision, high flux photon counting mode. We demonstrate a new detector configuration that enables operation in a high precision, medium flux spectroscopy mode, which opens the potential for a variety of new applications in medical imaging, non-destructive testing and baggage scanning. In particular, we describe the requirements of a coded aperture coherent scattering X-ray system that can perform fast imaging with accurate material discrimination.
First transannular Diels–Alder reactions involving tetrasubstituted non-activated dienophiles (1994)

Transannular Diels–Alder reactions of four 14-membered macrocyclic trienes (27, 28, 43, and 44) possessing a dimethyl tetrasubstituted dienophile have been investigated. Macrocycles having a cis-trans-cis (CTC) (27), a CTT (43), and a TTT (44) geometry produced the predicted trans-syn-cis (TSC) (45), cis-anti-cis (CAC) (48), and TAC (49) tricycles, respectively. The TTC macrocycle (28) gave exclusively the TST tricycle (46), no CSC tricycle (47) being observed. TTT macrocycle (44) underwent macrocyclization at a lower temperature than the TTC isomer (28).
Finite-key analysis of high-dimensional time-energy entanglement-based quantum key distribution (2013)

We present a security analysis against collective attacks for the recently proposed time-energy entanglement-based quantum key distribution protocol, given the practical constraints of single photon detector efficiency, channel loss, and finite-key considerations. We find a positive secure-key capacity when the key length increases beyond $10^4$ for eight-dimensional systems. The minimum key length required is reduced by the ability to post-select on coincident single-photon detection events. Including finite-key effects, we show the ability to establish a shared secret key over a 200 km fiber link.
Carbon Black Engineered Cementitious Composites - Mechanical and Electrical Characterization (2013)

First Name is required invalid characters Last Name is required invalid characters Email Address is required Invalid Email Address Invalid Email Address
Performance of concatenated channel codes and orthogonal space-time block codes (2006)

In this paper we analyze the performance of an important class of MIMO systems that of orthogonal space-time block codes concatenated with channel coding. This system configuration has an attractive combination of simplicity and performance. We study this system under spatially independent fading as well as correlated fading that may arise from the proximity of transmit or receive antennas or unfavorable scattering conditions. We consider the effects of time correlation and present a general analysis for the case where both spatial and temporal correlations exist in the system. We present simulation results for a variety of channel codes, including convolutional codes, turbo codes, trellis coded modulation (TCM), and multiple trellis coded modulation (MTCM), under quasi-static and block-fading Rayleigh as well as Rician fading. Simulations verify the validity of our analysis
DFM in practice (2008)

DFM has taken shape by virtue of manufacturers defining a series of "DFM activities", related to parametric and stochastic yield analysis and recommendations for design changes to improve yield. The picture is made more complex because the view from integrated device manufacturers, pure play foundries, and fabless semiconductor companies is not necessarily the same as they have different needs and constrains. This panel brings together DFM practitioners from each of these communities to discuss real experiences on the adoption level achieved so far as well as the impact in the manufactured products. The panel should be of interest of designers moving to advanced nodes (to learn from the experience of those that have "done it already") as well as those in the leading edge (such that they can compare experiences).
Supplementary Figure 1 from Sym004: A Novel Synergistic Anti–Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy (2023)

Supplementary Figure 1 from Sym004: A Novel Synergistic Anti–Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy
Bath Stability Monitoring for Electroless Cu Seed Formation in High Aspect Ratio TSV (2012)

Abstract not Available.
A multi-modality approach for enhancing 4D flow MRI via sparse representation (2021)

&lt;p&gt;The data and source code provided in this publication was used to enhance the blood flow measurements with in vivo 4D flow MRI in cerebral aneurysms using a multi-modality approach.&amp;nbsp;The approach, named Multi-modality Sparse Representation (MSR), reconstructs the velocity field from 4D flow MRI by searching for a sparse representation in a library of high-resolution velocity fields obtained from CFD and &lt;i&gt;in vitro&lt;/i&gt; PTV.&amp;nbsp;The MSR reconstruction enhanced the spatial resolution and velocity accuracy of the MRI data, and improved the reliability of the flow-derived hemodynamic parameters including pressure and wall shear stress (WSS).&lt;/p&gt; &lt;p&gt;The data provided here contains the velocity fields from in vivo 4D flow MRI, in vitro PTV, and patient-specific CFD simulations in two cerebral aneurysms&amp;nbsp;stored in MATLAB file format. The source code is written in Python.&lt;/p&gt;
Novel CACNA1A mutation causes febrile episodic ataxia with interictal cerebellar deficits (2003)

Episodic ataxia type 2 (EA2) is a dominantly inherited disorder, characterized by spells of ataxia, dysarthria, vertigo, and migraines, associated with mutations in the neuronal calcium-channel gene CACNA1A. Ataxic spells lasting minutes to hours are provoked by stress, exercise, or alcohol. Some patients exhibit nystagmus between spells and some develop progressive ataxia later in life. At least 21 distinct CACNA1A mutations have been identified in EA2. The clinical and genetic complexities of EA2 have offered few insights into the underlying pathogenic mechanisms for this disorder. We identified a novel EA2 kindred in which members had ataxic spells induced by fevers or high environmental temperature. We identified a novel CACNA1A mutation (nucleotides 1253+1 G-->A) that was present in all subjects with febrile spells or ataxia. Moreover, we found that, regardless of age or interictal clinical status, all affected subjects had objective evidence of abnormal saccades, ocular fixation, and postural stability. These findings suggest that early cerebellar dysfunction in EA2 results from the intrinsically abnormal properties of the CACNA1A channel rather than a degenerative process.
Altered phosphorylation of topoisomerase I following overexpression in an ovarian cancer cell line (2006)

There is a growing interest regarding the use of camptothecins (CPTs) for the management of ovarian cancer. Since topoisomerase I has been established as a prime target of these drugs in other experimental models, it was important to determine whether sensitivity to CPTs in ovarian cancer cells is also correlated with the cellular level of this enzyme. Despite the 7-fold increase in topoisomerase expression achieved by adenovirus-mediated expression, the sensitivity to a CPT derivative (topotecan), was not improved compared with control cells harboring an endogenous level of the enzyme. This observation is in accordance with the similar level of topoisomerase I activity found in control and overexpressing cells and suggests that these cells may efficiently regulate the enzyme activity. Indeed, topoisomerase I overexpressing cells are characterized by a lack of alkaline phosphatase sensitivity and elimination of the hyperphosphorylated form of the protein. Taken together, these observations strongly suggest that an alteration in the phosphorylation state of topoisomerase I could limit its activity and prevent improvement of CPT response in ovarian cancer cells. In addition, a limited extent of topoisomerase I phosphorylating activity was found in nuclear extract of OVCAR-3 cells. Hence, providing enhancement in topoisomerase I expression may not result in improvement of CPT response in ovarian cancer cells because of an efficient control of the phosphorylation state of the enzyme.
Diverse ATPase Proteins in Mobilomes Constitute a Large Potential Sink for Prokaryotic Host ATP (2021)

Prokaryote mobilome genomes rely on host machineries for survival and replication. Given that mobile genetic elements (MGEs) derive their energy from host cells, we investigated the diversity of ATP-utilizing proteins in MGE genomes to determine whether they might be associated with proteins that could suppress related host proteins that consume energy. A comprehensive search of 353 huge phage genomes revealed that up to 9% of the proteins have ATPase domains. For example, ATPase proteins constitute ∼3% of the genomes of Lak phages with ∼550 kbp genomes that occur in the microbiomes of humans and other animals. Statistical analysis shows the number of ATPase proteins increases linearly with genome length, consistent with a large sink for host ATP during replication of megaphages. Using metagenomic data from diverse environments, we found 505 mobilome proteins with ATPase domains fused to diverse functional domains. Among these composite ATPase proteins, 61.6% have known functional domains that could contribute to host energy diversion during the mobilome infection cycle. As many have domains that are known to interact with nucleic acids and proteins, we infer that numerous ATPase proteins are used during replication and for protection from host immune systems. We found a set of uncharacterized ATPase proteins with nuclease and protease activities, displaying unique domain architectures that are energy intensive based on the presence of multiple ATPase domains. In many cases, these composite ATPase proteins genomically co-localize with small proteins in genomic contexts that are reminiscent of toxin-antitoxin systems and phage helicase-antibacterial helicase systems. Small proteins that function as inhibitors may be a common strategy for control of cellular processes, thus could inspire future biochemical experiments for the development of new nucleic acid and protein manipulation tools, with diverse biotechnological applications.
Optical Spectral Imaging For Breast Margin Assessment: A Comprehensive Assessment of Sources of Contrast (2012)

Achieving tumor-free surgical margins is desired to avoid recurrence. Diffuse reflectance imaging can assess margin status; however, understanding tissue kinetics, cautery, and patient variability is necessary to exploit optical contrast to detect positive tumor margins.
Short and Open Circuited EBG Resonator Antennas: Miniaturization With a Shorting Plate and Dielectric Loading (2015)

A method is proposed to decrease the matching frequency of the recently introduced self-excited electromagnetic bandgap (EBG) resonator antenna (SE-EBG-RA). The method is based on the application of a metal shorting plate at the open end of the antenna which reduces the resonance. EBG unit cells are comprised of thick metal patches on top of a PEC-backed substrate, which are separated by tiny high aspect ratio (HAR) gaps. Two to six cells, each electrically much smaller than wavelength, are deployed in one-dimensional (1-D) as a fragment of EBG microstripline with high radiation properties. Both open-circuit (OC) and short-circuit (SC) versions are presented, the SC version being electrically smaller. The miniaturization effect of dielectric loading of HAR gaps is also examined. The characteristics of proposed structures as improved radiators in terms of bandwidth (BW), size, gain, and efficiency are demonstrated through parametric and comparative analyses and also prototyping. The efficiency, BW, and footprint of the smallest dielectric-loaded version, a two-cell SC SE-EBG-RA, are 96%, 3.5%, and 0.22λ × 0.28λ, respectively.
Sol–Gel Chemistry and Materials (2007)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTSol–Gel Chemistry and MaterialsBruce Dunn and Jeffrey I. ZinkView Author Information University of California, Los AngelesCite this: Acc. Chem. Res. 2007, 40, 9, 729Publication Date (Web):September 18, 2007Publication History Received1 August 2007Published online18 September 2007Published inissue 1 September 2007https://pubs.acs.org/doi/10.1021/ar700178bhttps://doi.org/10.1021/ar700178beditorialACS PublicationsCopyright © 2007 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views4131Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (60 KB) Get e-AlertscloseSUBJECTS:Amorphous materials,Biomaterials,Hybrid materials,Materials,Materials science Get e-Alerts
Performance of Antireflection Coatings Consisting of Multiple Discrete Layers and Comparison with Continuously Graded Antireflection Coatings (2010)

The performance of discrete multilayer and continuously graded antireflection coatings for omnidirectional broadband applications are compared It is shown that in practical cases where refractive index choices are constrained, discrete antireflection coatings can surpass the performance of continuously graded coatings by taking advantage of interference effects, which continuously graded coatings are expressly designed to avoid A four-layer antireflection coating designed using a genetic algorithm is fabricated, and is experimentally shown to have reflectivity lower than what is achievable for continuously graded designs (C) 2010 The Japan Society of Applied Physics
<title>Evaluating the propagation effects of time critical targeting</title> (2005)

As General John P. Jumper, Air Force Chief of Staff, noted the bulk of an Air Operations Center Air Tasking Order cycle is spent gathering information from different stovepipe intelligence assets, then manually evaluating the results and planning implications. This time consuming process is an obstacle that inhibits the real-time battlespace awareness needed by commanders to dynamically task assets to address time critical targets and help the Air Force meet its goal of “striking mobile and emerging targets in single digit minutes”. This paper describes how research performed for the Dynamic Intelligence Anticipation, Prioritization, and Exploitation System (DIAPES) supports this goal by leveraging advances in ontological modeling, intelligence data integration; artificial intelligence; and visualization. DIAPES applies automated analysis and visualization to an integrated ontology that specifies the relationships among intelligence and planning products and battlespace execution assets. This research seeks to enable commanders and analysts to perform 'what-if' scenarios to judge tradeoffs and determine the potential propagation effects that retasking assets to address time critical targets have throughout battlespace plans and participants.
Data from Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation (2023)

&lt;div&gt;Abstract&lt;p&gt;Pancreatic ductal adenocarcinoma (PDAC) is considered a “nonimmunogenic” neoplasm. Single-agent immunotherapies have failed to demonstrate significant clinical activity in PDAC and other “nonimmunogenic” tumors, in part due to a complex tumor microenvironment (TME) that provides a formidable barrier to immune infiltration and function. We designed a neoadjuvant and adjuvant clinical trial comparing an irradiated, granulocyte-macrophage colony-stimulating factor (GM-CSF)–secreting, allogeneic PDAC vaccine (GVAX) given as a single agent or in combination with low-dose cyclophosphamide to deplete regulatory T cells (Treg) as a means to study how the TME is altered by immunotherapy. Examination of resected PDACs revealed the formation of vaccine-induced intratumoral tertiary lymphoid aggregates in 33 of 39 patients 2 weeks after vaccine treatment. Immunohistochemical analysis showed these aggregates to be regulatory structures of adaptive immunity. Microarray analysis of microdissected aggregates identified gene-expression signatures in five signaling pathways involved in regulating immune-cell activation and trafficking that were associated with improved postvaccination responses. A suppressed Treg pathway and an enhanced Th17 pathway within these aggregates were associated with improved survival, enhanced postvaccination mesothelin-specific T-cell responses, and increased intratumoral Teff:Treg ratios. This study provides the first example of immune-based therapy converting a “nonimmunogenic” neoplasm into an “immunogenic” neoplasm by inducing infiltration of T cells and development of tertiary lymphoid structures in the TME. Post-GVAX T-cell infiltration and aggregate formation resulted in the upregulation of immunosuppressive regulatory mechanisms, including the PD-1–PD-L1 pathway, suggesting that patients with vaccine-primed PDAC may be better candidates than vaccine-naïve patients for immune checkpoint and other immunomodulatory therapies. &lt;i&gt;Cancer Immunol Res; 2(7); 616–31. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
ASTRX/OBLX (1994)

We describe ASTRX/OBLX, a synthesis system that can size high-performance analog circuit topologies to meet usersupplied linear performance specifications without designer-supplied equations. We present synthesis results for a large suite of circuit benchmarks and show that, when compared to prior approaches, ASTRX/OBLX can synthesize high-performance circuits with up to 3 orders of magnitude less initial design effort.
Consistent Least Squares Estimator for Co-Array-Based DOA Estimation (2018)

Sparse linear arrays (SLAs), such as nested and co-prime arrays, have the attractive capability of providing enhanced degrees of freedom by exploiting the co-array model. Accordingly, co-array-based Direction of Arrivals (Doas) estimation has recently gained considerable interest in array processing. The literature has suggested applying MUSIC on an augmented sample covariance matrix for co-array-based Doas estimation. In this paper, we propose a Least Squares (LS) estimator for co-array-based DoAs estimation employing the covariance fitting method as an alternative to MUSIC. We show that the proposed LS estimator provides consistent estimates of Doas of identifiable sources for SLAs. Additionally, an analytical expression for the large sample performance of the proposed estimator is derived. Numerical results illustrate the finite sample behavior in relation to the derived analytical expression. Moreover, the performance of the proposed LS estimator is compared to the co-array-based MUSIC.
Appearance of Different Lymphoid Cells in Synovial Tissue and in Peripheral Blood during the Course of Collagen II‐Induced Arthritis in Rats (1985)

The involvement of different sets of lymphoid cells in the development of collagen II-induced arthritis in rats was studied by means of immunohistochemical analyses on frozen sections of tissue from joint biopsy specimens taken at different phases of arthritis development. Particular attention was paid to cells involved in early pannus formation. Accumulation of anti-Ia-reactive cells close to the cartilage surface was seen early in the development of pannus, and the anti-Ia reactive cells could in later phases be seen infiltrating cartilage and crowding bone surfaces at sites of marginal erosion. With the help of monoclonal anti-T-cell subset antibodies and rabbit anti-rat immunoglobulin antiserum, it was demonstrated that synovial infiltration of T lymphocytes, particularly W3/25-reactive T "helper" cells, occurs very early in the development of arthritis, whereas a moderate increase of Ox 8-positive 'suppressor/cytotoxic' T cells and a small number of B cells and plasma cells are seen later in the course of the disease. Levels of Ia-expressing cells and of T cells belonging to different subsets were recorded in peripheral blood by means of immunocytochemical analyses on cell smears; no significant deviations from normal levels were seen during the development of arthritis.