gebhart/patrepeval huggingface dataset:
Stability and passivity analysis of systems with time varying parameters (2002)

This paper concerns passivity and stability analysis of linear time varying (LTV) systems characterized by parametric time variations. The first set of results quantify a trade off between the degree of passivity of the frozen systems and the rate of parameter variations, so that passivity of certain classes of such LTV systems is preserved. One class of systems examined has frozen systems whose transfer functions are multiaffinely parametrized. Another class considered includes linear circuits with time varying resistors, inductors capacitors and mutual inductors. The second set of results exposes the utility of these passivity results in stability analysis.
Preparation, characterization, and properties of novolac‐type phenolic/SiO2 hybrid organic–inorganic nanocomposite materials by sol–gel method (2003)

Abstract This article describes the preparation of novolac‐type phenolic resin/silica hybrid organic–inorganic nanocomposite, with a sol–gel process. The coupling agent was used to improve the interface between the organic and inorganic phases. The effect of the structure of the nanocomposite on its physical and chemical properties is discussed. The coupling agent reacts with the resin to form covalent bonds. The structure of the modified hybrid nanocomposites was identified with a Fourier transform infrared spectroscope. The silica network was characterized by nuclear magnetic resonance imaging ( 29 Si NMR). Results revealed that Q 4 (tetrasubstituted) and T 3 (trisubstituted) are the dominant microstructures. The size of the silica in the phenolic resin was characterized with a scanning electron microscope. The size of the particles of inorganic silica in the modified system was less than 100 nm. The nanocomposite exhibited good transparency. Moreover, the thermal and mechanical properties exhibited significant improvement. The modified hybrid composite exhibited favorable thermal properties. The temperature at which a weight loss of 5% occurred increased from 281 to 350 °C. The flexural strength increased by 6–30%. The limiting oxygen index of the nanocomposite reached 37, and the Underwriters Laboratory test was 94V‐0. Consequently, these materials possess excellent flame‐retardant properties. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 905–913, 2003
Abstract 052: Alpha1a-Adrenoceptor Genetic Variant-Triggered Hyperproliferation in Cardiovascular Cells is Mediated by Novel Interacting Protein Spinophilin (2014)

Objectives: Alpha1-Adrenergic Receptors (α1ARs), members of the G protein-coupled receptor (GPCR) superfamily, play a major role in regulating cardiovascular (CV) function. Recently, we discovered that naturally occurring human α1aAR-G247R (247R) genetic variant, identified in the 3rd intracellular loop (3iL) of the receptor in highly hypertensive patient, triggers constitutive hyperproliferation in fibroblasts, cardiomyoblasts and smooth muscle cells (SMC). Specific proteins mediating this signaling remain unknown. Spinophilin (SPL) is a ubiquitously expressed protein controlling GPCR signaling by binding its 3rd intracellular loop (3iL). We hypothesize that SPL mediates α1aAR signaling and examined whether SPL directly interacts with α1aAR-WT (WT) and 247R. Methods: Cells were co-transfected with HA-α1ARs and full length Myc-SPL or its fragments to determine SPL domains responsible for binding to α1ARs. Cell lysates were co-immunoprecipitated with HA-tag antibodies. SPL levels were analyzed by Western blotting. SPL knockdown experiments were performed by transiently transfecting cells with SPL or scrambled siRNA, cell proliferation was determined by cell counting. Results: We demonstrate a distinct interaction of SPL with WT and 247R, WT interaction being the strongest. Different domains of SPL differentially interact with WT or 247R. SPL 1-480aa fragment interacts stronger with WT indicating interaction with 3iL, while SPL 480-817 fragment interacts stronger with 247R. Endogenous SPL levels are increased in 247R cells compared to WT or control cells. Inhibition of SPL expression in SMC with siRNA reduces 247R-triggered hyperproliferation to near normal levels and has no effect in WT cells. Conclusions: We identified SPL as a novel interacting protein involved in mediating intracellular signaling of α1aAR and its genetic variant in CV cells. Different domains of SPL differentially bind to WT or 247R indicating that SPL has a distinct role in regulation of their signaling pathways. Our findings also reveal that SPL is critical for 247R-triggered EGFR transactivation pathways. Thus SPL could be considered as a potentially novel target in α1aAR-mediated cardiovascular disorders.
Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase‐encoding gene, MAN1, and its impact on pathogenicity (2001)

The polysaccharide capsule surrounding Cryptococcus neoformans comprises manose, xylose and glucuronic acid, of which mannose is the major constituent. The GDP-mannose biosynthesis pathway is highly conserved in fungi and consists of three key enzymes: phosphomannose isomerase (PMI), phosphomannomutase (PMM) and GDP-mannose pyrophosphorylase (GMP). The MAN1 gene, encoding for the PMI enzyme, was isolated and sequenced from C. neoformans, and a disruption of the MAN1 gene was generated. One MAN1 disruption mutant, man1, which showed poor capsule formation, reduced polysaccharide secretion and morphological abnormalities, was chosen for virulence studies. In both the rabbit and the mouse models of invasive cryptococcosis, man1 was shown to be severely impaired in its virulence, with complete elimination of the yeast from the host. A reconstituted strain of man1 was constructed using gene replacement at the native locus. The wild-type and reconstituted strains were significantly more virulent than the knock-out mutant in both animal models. Our findings reveal that PMI activity is essential for the survival of C. neoformans in the host. The fact that the man1 mutant was not pathogenic suggests that blocking mannose synthesis could be fungicidal in the mammalian host and thus an excellent target for antifungal drug development.
Near-Field Radiation Exposure Control in Slot-Loaded Microstrip Antenna: A Characteristic Mode Approach (2019)

Microstip antenna topology is commonly loaded with a narrow slot to manipulate the resonance frequency or impedance bandwidth. However, the tuning of the resonance frequency or impedance bandwidth results in the variation of the current and field distributions. In this regard, this work adopts the concept of characteristic modes to gain an initial understanding of the perturbation mechanism of the rectangular patch when loaded with a slot. The performance of microstrip antennas with finite ground plane is then studied using full-wave simulation. It has been found that the distribution of the induced current density is highly dependent on the orientation of the slot The incorporation of a narrow slot suppresses the nearby orthogonal eigen mode and, as a consequence, the radiation behavior is affected. Specifically, in the presence of biological tissues in the near-field region, both antenna input impedance properties and the realized gain are dependent on the slot orientation. Different examples are included for understanding the impact of slot loading on the energy absorption by biological tissues, by calculating the the specific absorption rate (SAR). The proposed analysis facilitates the design of miniaturized antenna geometries for biomedical applications via systematic loading of narrow slots.
Synthesis and Redox Properties of Thiophene Terephthalate Building Blocks for Low-Potential Conducting Redox Polymers (2015)

Terephthalate-substituted thiophene derivatives are promising redox-active components for anode materials in lithium-ion batteries. In this study, we present the synthesis of substituted 2-(thiophen-3-yl)terephthalate derivatives (TTDs) as suitable monomers for thiophene-based conducting redox polymers, along with their characterization by electrochemical and spectroscopic techniques. Density functional theory (DFT) calculations, utilizing the universal solvation model based on solute electron density (SMD), were used to predict both the first and the second reduction potentials of these TTDs. The computational results showed good agreement with the experimental data in nonaqueous acetonitrile solvent, with mean absolute errors of 30 and 40 mV for the first and second reduction steps, respectively. Time-dependent (TD) DFT calculations on TTDs indicated terephthalate local transitions at both 200 and 240 nm and charge-transfer transitions above 300 nm by examination of the involved molecular orbitals.
Initial Heart Rate Score Predicts New Onset Atrial Fibrillation in Pacemaker Patients (2023)

Abstract Background Heart Rate Score (HRSc), the percent of all atrial paced and sensed event in the largest 10 bpm rate histogram bin of a pacemaker, predicts survival in patients with cardiac devices. No correlation between HRSc and development of atrial fibrillation (AF) has been reported. Objective To evaluate the relationship between pacemaker post-implantation HRSc and newly-developed AF incidence. Methods Patients with dual-chamber pacemakers, implanted 2013-2017, with ALTITIUDE remote monitoring data with ≥600,000 beats of histogram data collected at baseline were included (N=34,543). HRSc was determined from the post-implantation histogram data during the initial 3 months. Patients were excluded if they had AF, defined as atrial high-rate episodes &gt;5 minutes or &gt;1% of right atrial beats &gt;170 bpm during the initial 3-months post-implantation. New AF, after the baseline period, was defined by each of the following: &gt;1%, &gt;10% or &gt;25% of atrial beats &gt;170 bpm or Atrial Tachycardia Response (ATR) events &gt;24 hr. Results Patients were followed a median of 2.8 (1.0-4.0) years. Patients with initial HRSc≥70% were older, had higher %RA pacing, had lower %RV pacing and were more likely programmed with rate-response vs subjects with HRSc&lt;70%. The incidence of AF increased in proportion to HRSc (Log-Rank P-value &lt;0.001); results were insensitive to AF definition. Initial HRSc (HR:1.07, 95% CI:1.05-1.09; P&lt;0.0001) independently predicted AF after adjusting for age, gender, % RV pacing and rate-response programming. The %RA pacing and initial HRSc correlated. Conclusion HRSc predicts subsequent AF independent of well-known risk factors in pacemaker patients.
Development of a stable radioiodinating reagent to label monoclonal antibodies for radiotherapy of cancer. (1989)

A method of radioiodinating monoclonal antibodies such that the labeled antibodies do not undergo in vivo deiodination has been studied. The method utilizes conjugation of succinimidyl para-iodobenzoate to the antibody. The iodobenzoate was radiolabeled by using an organometallic intermediate to facilitate the reaction. Thus, succinimidyl para-tri-n-butylstannylbenzoate was radiolabeled in 60-90% radiochemical yield and subsequently conjugated to the antibody in 80-90% yield. Animal biodistribution studies were carried out with two separate anti-melanoma antibodies (9.2.27 and NR-M1-05) labeled by this method, and examined in nude mice bearing human melanoma tumor xenografts. Very large differences in the localization of radioactivity were observed in the thyroids and stomachs of mice when the iodobenzoyl-labeled antibodies were compared with the same antibodies labeled using the chloramine-T method of radioiodination. Few other significant differences in the tissue distribution of the radioiodinated antibodies were seen.
Electromagnetic Fundamentals for Signal Integrity (2008)

This chapter contains sections titled: Maxwell's Equations Common Vector Operators Wave Propagation Electrostatics Magnetostatics Power Flow and the Poynting Vector Reflections of Electromagnetic Waves References Problems
Outer membrane cytochromes/flavin interactions in Shewanella spp.—A molecular perspective (2017)

Extracellular electron transfer (EET) is intrinsically associated with the core phenomena of energy harvesting/energy conversion in natural ecosystems and biotechnology applications. However, the mechanisms associated with EET are complex and involve molecular interactions that take place at the “bionano interface” where biotic/abiotic interactions are usually explored. This work provides molecular perspective on the electron transfer mechanism(s) employed by Shewanella oneidensis MR-1. Molecular docking simulations were used to explain the interfacial relationships between two outer-membrane cytochromes (OMC) OmcA and MtrC and riboflavin (RF) and flavin mononucleotide (FMN), respectively. OMC-flavin interactions were analyzed by studying the electrostatic potential, the hydrophilic/hydrophobic surface properties, and the van der Waals surface of the OMC proteins. As a result, it was proposed that the interactions between flavins and OMCs are based on geometrical recognition event. The possible docking positions of RF and FMN to OmcA and MtrC were also shown.
Comparing risk-based fuel treatment prioritization with alternative strategies for enhancing protection and resource management objectives (2022)

Abstract Background Advances in fire modeling help quantify and map various components and characterizations of wildfire risk and furthermore help evaluate the ability of fuel treatments to mitigate risk. However, a need remains for guidance in designing landscape-scale fuel treatments with protection objectives, resource management objectives, and wildfire response in mind. It is also important to consider how human factors related to risk tolerance may affect opportunities to manage fire. We build on these themes to illustrate an approach for examining whether, and how, fuel management can simultaneously minimize housing exposure while maximizing area suitable for expansion of beneficial wildfire. We generate multiple hypothetical post-treatment conditions according to distinct treatment prioritization schemes (Housing Protection, Federal Transmission, Random) and variable treatment extents and compare performance across strategies for a 8.5 million ha case study landscape in north-central New Mexico, USA. Results In general, we find that treating near housing units can provide the greatest level of protection relative to treating more remote wildlands to reduce transmission potential. Treating on federal lands to reduce federal transmission was highly effective at reducing exposure from federal fires and at expanding opportunities for beneficial fire but contributed comparatively little to reducing housing exposure from all fires. We find that treatment extents as low as 2.5–5% can yield significant benefits with spatially optimized strategies, whereas the random strategy did not perform comparably until reaching a much larger treatment extent. Increasing risk tolerance for housing exposure expanded the area suitable for managed fire, while decreasing risk tolerance for beneficial fire opportunity and flame length probability shrunk the area suitable for managed fire. Conclusions This work provides a contribution in terms of explicitly framing risk analysis and fuel treatment design around federal land and resource management objectives and adds to the knowledge base for designing effective landscape fuel treatment strategies that can protect communities and expand beneficial wildfire on a fire-prone landscape. Successful integration of these themes requires embracing all pillars of the National Cohesive Wildland Fire Management Strategy, including coordinated management of fuels on various ownerships, home ignition zone mitigation, and cross-boundary fire response planning that can guide fire operations in reducing transmission and expand response options.
Single-sensor multispeaker listening with acoustic metamaterials (2015)

Designing a "cocktail party listener" that functionally mimics the selective perception of a human auditory system has been pursued over the past decades. By exploiting acoustic metamaterials and compressive sensing, we present here a single-sensor listening device that separates simultaneous overlapping sounds from different sources. The device with a compact array of resonant metamaterials is demonstrated to distinguish three overlapping and independent sources with 96.67% correct audio recognition. Segregation of the audio signals is achieved using physical layer encoding without relying on source characteristics. This hardware approach to multichannel source separation can be applied to robust speech recognition and hearing aids and may be extended to other acoustic imaging and sensing applications.
Total synthesis of the first molecular Moebius strip (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of the first molecular Moebius stripDavid M. Walba, Rodney M. Richards, and R. Curtis HaltiwangerCite this: J. Am. Chem. Soc. 1982, 104, 11, 3219–3221Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June 1982https://pubs.acs.org/doi/10.1021/ja00375a051https://doi.org/10.1021/ja00375a051research-articleACS PublicationsRequest reuse permissionsArticle Views1533Altmetric-Citations166LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Teaching Neuro Images : Meningoencephalocele and CSF leak in chronic idiopathic intracranial hypertension (2023)

A 63-year-old woman with epilepsy and chronic headaches was admitted for status epilepticus. A lumbar puncture revealed increased opening pressure of 320 mm H2O and bacterial meningitis. MRI brain demonstrated a partial empty sella, tortuous optic nerve sheaths, flattening of the optic papillae, and numerous prominent arachnoid granulations, consistent with chronic idiopathic intracranial hypertension (IIH), as well as bright CSF signal and brain parenchyma within a left meningoencephalocele (figure, A). A CT cisternogram confirmed communication of the subarachnoid space of the meningoencephalocele with the left sphenoid sinus through a small osseous defect (figure, B). While most CSF leaks are related to trauma, IIH is increasingly recognized as a cause of spontaneous leaks.1,2 While the increased opening pressure may have been due to her acute meningitis, her headache symptoms and MRI findings are suggestive of longstanding intracranial hypertension. Monitoring and medical treatment of IIH must accompany surgical repair to avoid recurrence.2
Calculation of Scattering by the Distorted Wave Born Approximation (1979)

An approximate scattering theory that utilizes the exact solutions for spherical defects is being developed. A defect of arbitrary shape can be represented by a sphere S and a remainder volume δv. By treating δv as a perturbation, one obtains an approximate solution that contains non-trivial frequency dependence and phase information. The approach is expected to be useful for studying defects with small but significant deviations (such as sharp edges) from spherical shape.
The Role of NOTES and LESS in Minimally Invasive Reconstructive Urological Surgery (2010)

Natural orifice translumenal endoscopic surgery (NOTES™) and laparoendoscopic single-site surgery (LESS) are exciting new developments in the evolution of minimally invasive surgery with potential application to urologic reconstructive surgery. Both represent a natural progression of laparoscopic surgery with ever fewer and smaller incisions and each shares common challenges. NOTES™ as a concept offers the potential for surgery without any transcutaneous abdominal incisions. LESS appears to offer a natural intermediate step toward a NOTES™ approach and may prove more practical for many applications. LESS may be described as a laparoscopic procedure with a single cutaneous incision through which multiple trocars or ports are placed. The advantages of either approach relative to standard laparoscopy will need to be established. There are rapid technological advances that are propelling both approaches forward, making an exhaustive description of the techniques and equipment unfeasible.
Presteady-state Analysis of Avian Sarcoma Virus Integrase (2002)

The integrase-catalyzed insertion of the retroviral genome into the host chromosome involves two reactions in vivo: 1) the binding and endonucleolytic removal of the terminal dinucleotides of the viral DNA termini and 2) the recombination of the ends with the host DNA. Kukolj and Skalka (Kukolj, G., and Skalka, A. M. (1995) Genes Dev. 9, 2556-2567) have previously shown that tethering of the termini enhances the endonucleolytic activities of integrase. We have used 5'-5' phosphoramidites to design reverse-polarity tethers that allowed us to examine the reactivity of two viral long terminal repeat-derived sequences when concurrently bound to integrase and, additionally, developed presteady-state assays to analyze the initial exponential phase of the reaction, which is a measure of the amount of productive nucleoprotein complexes formed during preincubation of integrase and DNA. Furthermore, the reverse-polarity tether circumvents the integrase-catalyzed splicing reaction (Bao, K., Skalka, A. M., and Wong, I. (2002) J. Biol. Chem. 277, 12089-12098) that obscures accurate analysis of the reactivities of synapsed DNA substrates. Consequently, we were able to establish a lower limit of 0.2 s(-1) for the rate constant of the processing reaction. The analysis showed the physiologically relevant U3/U5 pair of viral ends to be the preferred substrate for integrase with the U3/U3 combination favored over the U5/U5 pair.
A Regularized RLS Algorithm for the Identification of Third-Order Tensors (2020)

The recently proposed recursive least-squares (RLS) algorithm for trilinear forms, namely RLS-TF, was designed for the identification of third-order tensors of rank one. In this context, a high-dimension system identification problem can be efficiently addressed (gaining in terms of both performance and complexity) based on tensor decompositions and modelling. In this paper, following the framework of the RLS-TF, we propose a regularized version of this algorithm, where the regularization terms are incorporated within the cost functions. Furthermore, the optimal regularization parameters are derived, aiming at attenuating the effects of the system noise. Simulation results support the performance features of the proposed algorithm, especially in terms of its robustness in noisy environments.
Tendencias en LEDs (diodos emisores de luz) visibles (2002)

El primer diodo comercial emisor de luz visible fue ofrecido por GE en 1965 al precio de $45.00 cada uno. Poco mas tarde eran obtenibles unidades comerciales GaAsP de Monsanto y Hewlett-Packard. El rendimiento de los primeros LEDs, en el orden de 0,1 lumen de flujo de salida por watt de potencia electrica era mas de 100 veces mas bajo que los 15 lumen/watt de una lampara incandescente tipica de 60 a 100 watt.