gebhart/patrepeval huggingface dataset:
Enantiospecific Total Synthesis of (−)-(E)16-Epiaffinisine, (+)-(E)16-Epinormacusine B, and (+)-Dehydro-16-epiaffinisine as well as the Stereocontrolled Total Synthesis of Alkaloid G (2003)

An efficient strategy is described for the total synthesis of the sarpagine-related indole alkaloids (-)-(E)16-epiaffinisine (1), (+)-(E)16-epinormacusine B (2), and (+)-dehydro-16-epiaffinisine (4). A key step employed the chemospecific and regiospecific hydroboration/oxidation at C(16)-C(17); this method has also resulted in the synthesis of (+)-dehydro-16-epinormacusine B (5). The oxy-anion Cope rearrangement followed by protonation of the enolate that resulted under conditions of kinetic control has been employed to generate the key asymmetric centers at C(15), C(16), and C(20) in alkaloid G (7) in a highly stereocontrolled fashion (>43:1). Conditions that favor control of the sarpagine stereochemistry at C(16) vs the epimeric ajmaline configuration at the same stereocenter have been determined. The formation of the required cyclic ether in 4, 5, and 7 was realized with complete control from the top face on treatment of the corresponding alcohols with DDQ/THF or DDQ/aq THF in excellent yields.
Color‐by‐Blue QD‐Emissive LCD Enabled by Replacing RGB Color Filters with Narrow‐Band GR InP/ZnSeS/ZnS QD Films (2018)

Abstract Color‐by‐blue quantum dot (QD)‐emissive liquid‐crystal displays (LCDs) with eco‐friendly, green, red (GR) InP/ZnSeS/ZnS QD films are introduced to overcome the disadvantages of conventional color‐by‐white color filter (CF)‐assisted LCDs, such as a narrow viewing angle, low external device efficiency of these types of LCDs, and a restricted color gamut. In this study, the color‐by‐blue InP‐based QD‐emissive LCD consists of a blue (B) light‐emitting diode (LED) and GR InP‐based QD films sandwiched between a light recycling filter and a long‐wavelength pass dichroic filter. The GR InP‐based QDs are synthesized with a high photoluminescence quantum yield (&gt;77%) and narrow bandwidth (&lt;40 nm), which are suitable for display applications. The overall enhancement of InP‐based QD‐emissive LCDs, in this case by the enhanced efficiency of a blue LED backlight transmitted through the LC shutter compared to a white LED backlight and the improved efficiency of the enlarged color gamut, is 2.42 times that of a conventional red, green, and blue (RGB) CF‐LCD with a GR phosphor‐converted (pc)‐LED (a B LED + R K 2 SiF 6 :Mn + G β‐SiAlON:Eu phosphor) backlight. Therefore, this considerable enhancement of the external efficiency of a QD‐emissive LCD makes it more feasible as a replacement for conventional RGB CF‐assisted LCDs.
Generalized iterative frequency domain deconvolution technique (2002)

The deconvolution problem is mathematically classified as an ill-posed problem. The authors present a fast, robust, and accurate iterative frequency domain deconvolution technique that tackles this ill-posed problem. In an example, they use the new deconvolution technique to calculate the time domain reflection coefficient of a double step-in-width microstrip line. This deconvolution algorithm is much faster, more accurate, more robust, and less sensitive to noise than traditional algorithms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Pressure-induced reemergence of superconductivity in BaIr2Ge7 and Ba3Ir4Ge16 with cage structures (2022)

Clathrate-like or caged compounds have attracted great interest owing to their structural flexibility, as well as their fertile physical properties. Here, we report the pressure-induced reemergence of superconductivity in BaIr2Ge7 and Ba3Ir4Ge16, two new caged superconductors with two-dimensional building blocks of cage structures. After suppression of the ambient-pressure superconducting (SC-I) states, new superconducting (SC-II) states emerge unexpectedly, with Tc increased to a maximum of 4.4 and 4.0 K for BaIr2Ge7 and Ba3Ir4Ge16, respectively. Combined with high-pressure synchrotron x-ray diffraction and Raman measurements, we propose that the reemergence of superconductivity in these caged superconductors can be ascribed to a pressure-induced phonon softening linked to cage shrinkage.
Supplemental Methods from Bayesian Network Inference Modeling Identifies TRIB1 as a Novel Regulator of Cell-Cycle Progression and Survival in Cancer Cells (2023)

&lt;p&gt;Methods for Real-Time Quantitative RT-PCR, Assessment of medal accuracy, Gene expression, copy number and survival analysis,&lt;/p&gt;
Assessing the Risk-Benefit Ratio of Scoliosis Surgery in Cerebral Palsy: Surgery Is Worth It (2018)

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Consolidation of strong colloidal gels under arbitrary compressive loadings (2020)

Although highly successful, classical constitutive theories for the consolidation of strong colloidal gels are limited to one-dimensional (1D) uniaxial consolidation. Many consolidation applications are inherently multidimensional and there currently exists little understanding and no constitutive theory for how strong colloidal gels consolidate under arbitrary compressive loadings. In this study, we address this shortcoming by considering the consolidation mechanics of strong colloidal gels under arbitrary compressive loadings via 2D DEM biaxial simulations of assemblies of cohesive frictional particles. We show that although particle-scale consolidation differs significantly between uniaxial and isotropic consolidation, the maximum normal stress during consolidation is a unique function of the volumetric strain and hence the concentration of the solids phase. We use these insights to develop a generalised constitutive model for the macroscopic compressive rheology under arbitrary compressive loadings that is consistent with the classical constitutive model for uniaxial consolidation. Surprisingly, we find that this generalized constitutive model can predict multidimensional consolidation under arbitrary compressive loadings without need for further characterisation beyond uniaxial consolidation. These results provide significant insights into the consolidation of strong colloidal gels and facilitate prediction of multi-dimensional consolidation over a wide range of applications, and so represents an initial foray toward the development of a tensorial rheology of strong colloidal gels.
Stable expression of biologically active recombinant bovine interleukin‐4 in Trypanosoma brucei (2001)

We have explored the potential of Trypanosoma brucei as a eukaryotic expression system. Procyclic forms, which correspond to an insect-adapted stage, can easily be cultured in vitro. The cells grow to densities approximately 10-fold greater than higher eukaryotic cells and are not infectious for mammals. An expression vector which can stably integrate into the genome was used to express high levels of recombinant bovine interleukin-4 (IL-4). Trypanosome-derived IL-4 is released into the medium and is biologically active. The recombinant protein down-regulates CD14 expression in human macrophages and inhibits NO production by stimulated bovine macrophages.
Periodontal Soft Tissue Root Coverage Procedures: Practical Applications From the AAP Regeneration Workshop (2015)

Focused Clinical Question: How should gingival recession (GR) defects be managed based on current evidence? Summary: The purpose of this practical application is to illustrate the management of GR defects with a primary outcome goal of complete root coverage. The consensus in dental literature and among expert clinicians is that root coverage may be attained through the application of different procedures and that outcomes are generally measured by reduced defect depth, gain in clinical attachment, and an increase in keratinized tissue (KT). These procedures may include the use of: 1) subepithelial connective tissue graft (SCTG); 2) coronally advanced flap; 3) free gingival graft; and 4) soft tissue graft substitutes (acellular dermal matrix and xenogeneic collagen matrix materials) and biologics (recombinant human platelet-derived growth factor and enamel matrix derivative). The variability in these techniques revolves around the inclusion or avoidance of a palatal donor graft. The decision as to how to approach a specific clinical GR-type defect should be a combination of considerations relative to the clinician's surgical goals and the patient's understanding of the anticipated outcome. The associated systematic review (Chambrone and Tatakis, J Periodontol 2015;86(Suppl.):S8-S51) provides clear evidence that SCTG-based procedures provide the best outcome for mean and complete root coverage, as well as an increase in KT. Patient-reported outcomes, a topic that needs additional research, should be considered in the decision-making process. Conclusion: Based on the available evidence and the illustrated cases included in this practical application, root coverage can be predictably achieved and a successful clinical outcome can be maintained long term.
An Analytical-Experimental Study for the Determination of the Effective Thermal Conductivity of High Porosity Fibrous Foams (1999)

Abstract In this paper, we present a comprehensive analysis for estimating the effective thermal conductivity of high porosity fibrous foams. Commercially available fibrous foams form a complex array of interconnected fibers with an irregular lump of metal at the intersection of two fibers. In our theoretical analysis, we represent this structure by a model consisting of two-dimensional hexagonal arrays where the fibers form the sides of the hexagons. The lump is taken into account by considering a square, hexagonal or circular blob of metal at the intersection. The analysis shows that the effective thermal conductivity of the foam depends strongly on the porosity and the ratio of the cross-sections of the fiber and the intersection. It has no systematic dependence on pore density. Further, the choice of the geometric configuration of the intersection affects the estimate of the effective thermal conductivity. Experimental data with aluminum and Reticulated Vitreous Carbon (RVC) foams, using air and water as fluid media are used to validate the analytical predictions. Finally, the experimental results are used to arrive at a simple, closed-form empirical correlation for estimating the effective thermal conductivity in terms of the porosity, and the solid and fluid conductivities.
MV Surge Arresters Monitoring Using Drone Technology (2019)

This paper presents a pole-mounted measurement system to detect the leakage current of surge arresters. Such a current is a paramount index to determine the aging of the surge arrester. Moreover, all the measurements acquired by the developed pole- mounted system are collected using drones. This way, in every drone flight a huge amount of data can be gathered from the grid. Hence, improving and fastening the power network monitoring and maintenance.
Dehydroepiandrosterone Supplementation May Benefit Women with Asthma Who Have Low Androgen Levels: A Pilot Study (2019)

Endocrine treatments (corticosteroids) are a mainstay of anti-inflammatory management for moderate and severe asthma. Their use has improved asthma outcomes. Androgens also reduce airway inflammation and promote airway smooth muscle relaxation, but are rarely used clinically for asthma treatment. Our results suggest that the over-the-counter steroid DHEA may improve lung function in asthma outcomes among women with DHEAS < 200 ug/dL.
Reanalysis of single-cell RNA sequencing data does not support herpes simplex virus 1 latency in non-neuronal ganglionic cells in mice (2023)

Most individuals are latently infected with herpes simplex virus type 1 (HSV-1) and it is well-established that HSV-1 establishes latency in sensory neurons of peripheral ganglia. However, it was recently proposed that latent virus is also present in immune cells recovered from ganglia in a mouse model used for studying latency. Here, we reanalyzed the single-cell RNA sequencing (scRNA-Seq) data that formed the basis for this conclusion. Unexpectedly, off-target priming in 3' scRNA-Seq experiments enabled the detection of non-polyadenylated HSV-1 <i>latency-associated transcript</i> (<i>LAT</i>) intronic RNAs. However, <i>LAT</i> reads were nearexclusively detected in a mixed population of cells undergoing cell death. Specific loss of HSV1 <i>LAT</i> and neuronal transcripts during quality control filtering indicated widespread destruction of neurons, supporting the presence of contaminating cell-free RNA in other cells following tissue processing. In conclusion, the reported detection of latent HSV-1 in non-neuronal cells is best explained by inaccuracies in the data analyses.
High Speed Overwritable Phase Change Optical Disk Material (1987)

It was found that GeTe-Sb2Te3 pseud-binary amorphous alloy films showed remarkably fast switching properties to laser irradiation. By the static laser irradiation test, the film whose composition corresponded to stoichiometric compound of GeSb2Te4 were crystallized within 50ns of pulse duration at power of 8mW, whilst they could be amorphized with the same pulse duration at power of 20mW. Direct overwriting cycle test was performed on the revolving disk system for 10 5 times using single laser beam. CNR of more than 50dB and erasability of -22dB were obtained for linear velocity of 22m/s and overwriting frequencies of 5 and 7 MHz. The laser powers were 22 mW for recording and 10 mW for erasing. These materials will be applicable to high data rate direct overwritable disk media.
Surface Mediated Hydride Transfer Reaction of a Diarylmethyl Head Group Functionalized Poly(isobutyl vinyl ether) with Triphenylmethylium (2001)

Poly(isobutyl vinyl ether) (PIBVE) with bis(4-methoxyphenyl)methyl-head-group is transformed into a cationically active macro initiator by a hydride transfer reaction with silica surface coordinated triphenylmethylium as the hydride acceptor. The formation of the macrocation is investigated directly by UV/Vis spectroscopy on the surface of the silica particles and by GPC analysis of the surrounding solution. The hydride transfer reaction can be observed on the surface of the silica in a narrow temperature window between –5 and + 5°C. The use of the novel silica supported macrocation for a block copolymer synthesis with N-vinylcarbazol (NVC) is demonstrated.
Di-tert-butylcarbene: the low temperature photochemistry of di-tert-butyldiazomethane (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDi-tert-butylcarbene: the low temperature photochemistry of di-tert-butyldiazomethaneJames E. Gano, Richard H. Wettach, Matthew S. Platz, and V. P. SenthilnathanCite this: J. Am. Chem. Soc. 1982, 104, 8, 2326–2327Publication Date (Print):April 1, 1982Publication History Published online1 May 2002Published inissue 1 April 1982https://pubs.acs.org/doi/10.1021/ja00372a045https://doi.org/10.1021/ja00372a045research-articleACS PublicationsRequest reuse permissionsArticle Views229Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Hydrogen, Electron Donor, and Polymerization Temperature on Poly(propylene) Microstructure (2012)

Abstract Summary: Polypropylene made with an industrial heterogeneous Ziegler‐Natta catalyst was characterized using high temperature GPC, 13 C NMR, and Crystallization Elution Fractionation (CEF). The effect of hydrogen and electron donor during polymerization on poly(propylene) microstructure was investigated at two temperatures. In addition to the expected electron donor effect on polypropylene tacticity, hydrogen was also found to increase polypropylene tacticity. The effect of changing these polymerization conditions on molecular weight and polydispersity was also investigated. Finally, CEF profiles show how the crystallizability of polypropylene increases by adding hydrogen and electron donor to the reactor.
Layout small-angle rotation and shift for EUV defect mitigation (2012)

Blank defect mitigation is crucial for extreme ultraviolet (EUV) lithography. One of the existing options is to relocate patterns to avoid defect impact. However, when the defect number increases, only pattern shift in X-Y directions becomes far from enough, requiring the reticle holder rotate a small angle to provide a third exploring dimension. This non-trivial extension from 2D to 3D exploration requests efficient runtime as well as enough accuracy to handle different defect sizes and locations on the different features. In this paper, we present the first work with a detailed algorithm to find the optimal shift and rotation for layout patterns on blanks. Compared to the straightforward method, which is to check every pair of defect and feature at every possible relocation position, our proposed algorithm can significantly reduce the runtime complexity to scale linearly with the size of the full solution space. The experimental results validate our method and show a largely increased success rate of defect mitigation by shift and rotation.
Facile preparation of leukotrienes C4, D4 and E4 containing carbon‐13 and nitrogen‐15 for quantification of cysteinyl leukotrienes by mass spectrometry (2007)

With the recent ability to use combined liquid chromatography/electrospray tandem mass spectrometry to analyze for several eicosanoids in biological samples in a single and rapid experiment, heavy isotope-labeled eicosanoids are needed as internal standards in order to quantify eicosanoid analytes. The present study describes a practical preparation of cysteinyl leukotrienes (leukotriene C(4), D(4) and E(4)) with three (13)C atoms and one (15)N atom in the cysteinyl residue. The method involves solid-phase peptide synthesis to make glutathione with heavy isotopes in the cysteinyl residue and reaction of this tripeptide with commercially available leukotriene A(4) methyl ester to give labeled leukotriene C(4) methyl ester, which is hydrolyzed to labeled leukotriene C(4). Labeled leukotriene E(4) is prepared in the same way with the use of labeled cysteine. Labeled leukotriene D(4) is prepared by treatment of labeled leukotriene C(4) with commercially available γ-glutamyl transpeptidase.
A hybrid quarantine defense (2004)

We study the strengths, weaknesses, and potential synergies of two complementary worm quarantine defense strategies under various worm attack profiles. We observe their abilities to delay or suppress infection growth rates under two propagation techniques and three scan rates, and explore the potential synergies in combining these two complementary quarantine strategies. We compare the performance of the individual strategies against a hybrid combination strategy, and conclude that the hybrid strategy yields substantial performance improvements, beyond what either technique provides independently. This result offers potential new directions in hybrid quarantine defenses.
Dehydration assessment via a portable, single sided magnetic resonance sensor (2019)

Performing multicomponent T2 relaxometry localized to the skeletal muscle with a miniaturized MR sensor provides a noninvasive, physiologically relevant measure of dehydration induced fluid loss in a mouse model. This approach offers sensor portability, reduced system complexity, fully automated operation, and low cost compared with MRI. This approach may serve as a versatile and portable point of care technique for dehydration monitoring.
Variable Contribution of Different Monocloncal Antibodies to NK Cell-Mediated ADCC Against Primary CLL Cells. (2007)

Abstract Chronic Lymphocytic Leukemia (CLL) is characterized by the expression of the B-cell antigens CD19, 20 and 22, along with CD5 and CD23. These antigens make the malignant cells an ideal target for monoclonal antibody (mAb) therapy. Although the mechanism of action of mAbs is complex and not fully understood, one well-described action is antibody-dependent cellular cytotoxicity (ADCC). Binding of mAb to its target surface antigen initiates cytotoxicity through the interaction of the Fc portion of the mAb with the Fc receptor (FcR) on natural killer (NK) cells. This triggers release of perforin and granzymes from NK cells, and subsequent killing of the target cells. This study’s objectives were to measure ADCC of 4 different mAbs against primary CLL cells, and determine if cytotoxicity is dependent on antigen density. Methods: Mononuclear cells from 16 patients with untreated CLL were separated by density gradient separation and served as targets. The antigen density for CD20, 22 and 23 of each patient sample was quantified by flow cytometry. Effector cells for ADCC were NK-92 cells that do not express FcR, and a high affinity Fc receptor-expressing NK-92 variant (NK92.26.5) that also expresses inhibitory receptors (i.e. KIR). A fluourochrome-based flow cytometric assay determined ADCC by subtracting NK-92 induced cytotoxicity from NK-92.26.5 induced killing. Monoclonal antibodies tested were Rituximab (anti-CD20, Biogen/IDEC), Veltuzumab (anti-CD20, Immunomedics), Epratuzumab (anti-CD22, Immunomedics), and Lumiliximab (anti-CD23, Biogen/IDEC). Results: Mean ADCC of the four antibodies tested against 16 primary CLL cells were: 46.5% for Rituximab; 43.4% for Veltuzumab; 5.8% for Epratuzumab; 8.8% for Lumiliximab. Cytotoxicity of NK-92 and NK-92.26.5 against CLL cells without antibody ranged from 2–6%. Mean antigen density on the 16 CLL patient specimens were: CD20: 27,900 (range: 10,000–56,100); CD22: 820 (600–1300); CD23: 9870 (2340–14,800). Conclusions: We have developed a reliable in vitro assay to measure ADCC of mAbs against CLL cells. Our results indicate that ADCC contributes to cytotoxcity of CLL in vitro, and suggest that the magnitude of ADCC depends upon the surface antigen targeted. Anti-CD20 antibodies had significantly greater ADCC than the anti-CD22 and CD23 antibodies. This pattern was consistent in all patient cells tested. A similar pattern was observed with the surface antigen density on CLL cells tested, suggesting a correlation between cell surface antigen density and ADCC. Our results also suggest that resistance of primary CLL cells toward NK-mediated killing can be overcome by monoclonal antibodies even in the presence of inhibitory KIR expression on NK cells.
How to implement GDT in an institution and at the national level (2014)

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