gebhart/patrepeval huggingface dataset:
Data-driven inversion-based control of nonlinear systems (2015)

In this paper, we introduce the Data-Driven Inversion-Based Control (D2-IBC) method for nonlinear control system design. The method relies on a two degree-of-freedom architecture, with a nonlinear controller and a linear controller running in parallel, and does not require any detailed physical knowledge of the plant to control. Specifically, we use input/output data to synthesize the control action by employing convex optimization tools only. We show the effectiveness of the proposed approach on a simulation example, where the D2-IBC performance is also compared to that of the Direct FeedbacK (DFK) design approach, a benchmark method for nonlinear controller design from data.
Linear Precoding in Multibeam SatComs: Practical Constraints (2013)

peer reviewed
FDTD Modeling of Indoor Propagation with Frequency Averaging (2019)

The presence of numerical dispersion and anisotropy in the finite-difference time-domain (FDTD) method leads to an error in the phase of the numerical waves which in turn degrades the accuracy of the simulated electric field (E-field). In this paper, the error in the mean magnitude of the numerical E-field obtained by averaging over frequency is investigated. The central frequency, at which the study is performed, is 3 GHz and different averaging bandwidths are tested to check the accuracy of representing the large-scale fading. By comparing with measurements, it is found that before averaging the maximum error in the numerical results is of 64% for empty room and 57% for office scenario. However, the maximum error in the mean magnitude of the FDTD E-field, when averaging over bandwidth of 200 MHz is employed, is of 36% and 45% for empty room and office scenario, respectively.
Interaction-Oriented Programming (2021)

Interaction-Oriented Programming (IOP) refers to multiagent concepts, languages, and programming models for engineering applications that are characterized by interactions between autonomous parties. Such applications arise in domains such as e-commerce, health care, and finance. Owing to the autonomy of the principals involved, such applications are conceptually decentralized. We demonstrate how to specify a decentralized application flexibly and how to engineer correct, fault-tolerant endpoints (agents) for the principals in a straightforward manner. Notably, the entire application is realized as agents communicating over an unordered, unreliable messaging infrastructure (our implementations in fact use UDP). IOP departs from traditional distributed systems approaches that rely on guarantees in the application's communication infrastructure, e.g., for ordering and fault tolerance. Notably, IOP shows how to address application semantics, the holy grail of distributed systems.
Stereochemistry of hydrogen loss on formation of the vinyl group in the biosynthesis of ravidomycin (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemistry of hydrogen loss on formation of the vinyl group in the biosynthesis of ravidomycinRobert F. Keyes and David G. I. KingstonCite this: J. Org. Chem. 1989, 54, 26, 6127–6129Publication Date (Print):December 1, 1989Publication History Published online1 May 2002Published inissue 1 December 1989https://doi.org/10.1021/jo00287a031RIGHTS & PERMISSIONSArticle Views65Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (434 KB) Get e-Alerts Get e-Alerts
Electromagnetic assessment of force distribution for common control strategies in permanent magnet synchronous motors (2011)

Over the past several decades, the control of electric machines has typically been viewed using a “black box” approach which typically involves the manipulation of voltage and current to generate desired characteristics. However, for the purpose of designing and controlling the permanent magnet synchronous motor (PMSM) efficiently, a thorough understanding of the magnetic field parameters can play a significant role. In this paper, finite element analysis (FEA) is used to perform a detailed analysis of radial and tangential components of force in a PMSM under vector control as well as direct torque control (DTC) strategy. Understanding distribution and dynamic process of normal and tangential force is particularly useful for design engineers since it can strategically optimize specific attributes of the machine. These results can also be used to explain the operation of the machine under these control strategies and develop and be used to develop more efficient machine geometries.
Vacuum-Assisted Hot-Forming Using Tailored Laminate Temperature (2021)

Abstract A non-isothermal vacuum assisted hot-forming process using tailored laminate temperature is introduced. By using process simulation and manufacturing experiments, improved laminate quality is achieved compared to the standard hot-forming process. Furthermore, it is also shown that the manufacturing time in the clean room can be reduced to one tenth of the standard process time. In this study 8.4 mm thick quasi-isotropic laminates from unidirectional prepreg were laid up flat with an automatic tape laying machine and hot-formed to a U-shaped laminate. The laminates were then cured in a concave mould with standard bag on the inside. A complete tailored temperature hot-forming cycle of 7.5 min produced a very good final laminate quality with a total thickness variation as low as 4.0% and without wrinkles or indications of porosity. With a 4 min hot-forming cycle the thickness variation was also acceptable at 8%.
Voltage feedback based harmonic compensation for an offshore wind power plant (2016)

When an offshore wind power plant is connected to the grid, there is a risk of amplification of certain harmonics and appearance resonances at the point of connection due to the interaction between the grid network and the wind power plant network. Hence, the plant developer is obliged to maintain the harmonic distortion at the point of common coupling within the planning level limits using harmonic compensation, which is usually done by passive filters. In this paper a novel active harmonic compensation technique using voltage feedback from a non-local bus has been proposed and analyzed. Its effectiveness has been demonstrated through real time simulations on a test system model.
Two-Stage Multiscale Search for Sparse Targets (2011)

We consider the problem of energy constrained and noise-limited search for targets that are sparsely distributed over a large area. We propose a multiscale search algorithm that significantly reduces the search time of the adaptive resource allocation policy (ARAP) introduced in [Bashan 2008]. Similarly to ARAP, the proposed approach scans a <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Q</i> -cell partition of the search area in two stages: first the entire domain is scanned and second a subset of the domain, suspected of containing targets, is rescanned. The search strategy of the proposed algorithm is driven by maximization of a modified version of the previously introduced ARAP objective function, which is a surrogate for energy constrained target detection performance. We analyze the performance of the proposed multistage ARAP approach and show that it can reduce mean search time with respect to ARAP for equivalent energy constrained detection performance. To illustrate the potential gains of M-ARAP, we simulate a moving target indicator (MTI) radar system and show that M-ARAP achieves an estimation performance gain of 7 dB and a 85% reduction in scan time as compared to an exhaustive search. This comes within 1 dB of the previously introduced ARAP algorithm at a fraction of its required scan time.
Nerve fiber layer splaying at vascular crossings. (2002)

To examine the anatomic relationships of retinal blood vessels to the nerve fiber layer.Retinal flat preparations from monkey and cat were stained with methylene blue dye and examined by light microscopy.A focal transition in nerve fiber bundle patterns occurs just above major retinal blood vessels. Bundles abandon a compact form and splay open just as they reach a major blood vessel. Maximum separation of axon fascicles occurs immediately above the blood vessel and the bundles reform after the crossing of the blood vessel is complete. In so doing, nerve fiber bundles temporarily thin and broaden, assuming the shape of an inverted hull. In contrast, at the retinal periphery, minor blood vessels and axon fascicles have no special relationship to each other.At major blood vessel crossings, a focal alteration in nerve fiber bundle anatomy takes place under which local deformability may be enhanced. This adaptation probably lessens the risk of injury to ganglion cell axons from vascular compression. In addition, deflection of the nerve fiber pathway obviates the need for major blood vessels to bend or kink to achieve a crossing, thus avoiding turbulent flow.
High resolution speech feature parametrization for monophone-based stressed speech recognition (2000)

This letter investigates the impact of stress on monophone speech recognition accuracy and proposes a new set of acoustic parameters based on high resolution wavelet analysis. The two parameter schemes are entitled wavelet packet parameters (WPP) and subband-based cepstral parameters (SBC). The performance of these features is compared to traditional Mel-frequency cepstral coefficients (MFCC) for stressed speech monophone recognition. The stressed speaking styles considered are neutral, angry, loud, and Lombard effect speech from the SUSAS database. An overall monophone recognition improvement of 20.4% and 17.2% is achieved for loud and angry stressed speech, with a corresponding increase in the neutral monophone rate of 9.9% over MFCC parameters.
Nonlinear adaptive bilinear filters for active noise control systems (2005)

The reference and error channels of active noise control (ANC) systems may be saturated in real-world applications if the noise level exceeds the dynamic range of the electronic devices. This nonlinear saturation degrades the performance of ANC systems that use linear adaptive filters with the filtered-X least-mean-square (FXLMS) algorithm. This paper derives a bilinear FXLMS algorithm for nonlinear adaptive filters to solve the problems of signal saturation and other nonlinear distortions that occur in ANC systems used for practical applications. The performance of this bilinear adaptive filter is evaluated in terms of convergence speed, residual noise in steady state, and the computational complexity for different filter lengths. Computer simulations verify that the nonlinear adaptive filter with the associated bilinear FXLMS algorithm is more effective in reducing saturation effects in ANC systems than a linear filter and a nonlinear Volterra filter with the FXLMS algorithm.
One pot synthesis of cyclohexanone oxime from nitrobenzene using a bifunctional catalyst (2013)

Cyclohexanone oxime is formed from nitrobenzene with 97% yield in a one-pot reaction catalysed by palladium and gold nanoparticles on carbon. The reaction is carried out under hydrogen at 60 °C and the overall transformation involves a multi-step catalysed mechanism from which intermediates and catalytically active species have been identified.
Integrative Acceleration of First-order Boolean Masking for Embedded IoT Devices (2019)

Physical attacks, especially side-channel attacks, are threats to IoT devices which are located everywhere in the field; and therefore, protecting such devices against side-channel attacks is one of our emerging issues. Toward that, Coron et al. gave an efficient arithmetic-to-Boolean mask conversion algorithm which enables us to protect cryptographic algorithms including arithmetic operations, such as hash functions, from the attacks. Recently, Biryukov et al. improved it by locally optimizing subroutines of the conversion algorithm. In this paper, we revisit the algorithm. Unlike Biryukov et al., we improve the Coron et al.'s algorithm with integrative optimizations over the subroutines. The gains against these algorithms are about 22.6% and 7.0% in the general setting. We also apply our algorithm to HMAC-SHA-1 and have an experiment to show that the implementation on a test vehicle smartcard leaks no sensitive information, i.e., secure against the first-order side-channel attack, with the ISO/IEC17825 test.
Fiber devices for optical monitoring applications (2003)

This paper describes how optical monitors to measure quantities such as wavelength, polarization and pulse shape, may be realized using fiber-based components, and discusses their merits in fiber applications.
Thermal Analysis of a Micro-Polymerase Chain Reaction Device (2004)

Micro-scale polymerase chain reaction (micro-PCR) systems offer substantial advantages over macro-scale systems. Smaller sample volumes are required, and faster process times are feasible. Thermal control of micro-PCR systems is a substantial technical challenge, however. The PCR process requires the fluid sample to be cycled through three temperature ranges — typically 90–95°C, 50–65°C and 72–77°C for denaturation, hybridisation and replication respectively. Durations of the three steps are required to be in the ratio of 4:4:9. In this paper, the thermal analysis of a continuous flow micro-PCR device is reported. The objective of the analysis is to optimize the thermal performance of the device for fast amplification cycles with high efficiency - an efficient PCR features rapid heating and cooling between steps, and good temperature uniformity within each step. The device comprises an array of parallel microchannels formed within a polypropylene substrate to carry fluid, with the base of the substrate mounted on an aluminium carrier. Substrate depth is 500 micron, and each channel is 60 micron wide by 40 micron deep. Thermoelectric cells (TECs) are bonded to the carrier, and powered by a thermoelectric controller with feedback from sensors embedded in the carrier. A Pyrex Glass slide is bonded to the substrate to form closed channels. Arrays of film heaters mounted on the slide adjacent to the channel are used to establish the required temperature regions along the channel. By pumping the fluid at a fixed flow rate, temperature cycling of specific period is achieved. Thermal analysis of the substrate is performed using an approximate closed-form solution, in conjunction with Finite Element (FE) and Computational Fluid Dynamics (CFD) simulations. The analysis is used to conduct a parametric study in order to determine the optimum configurations of substrate materials, cooling conditions, heaters and flow rates required to impose specific temperature cycles. The use of thermoelectric cells is shown to increase the rate of change of temperature between the various regions, improving the efficiency and decreasing the cycle time of the PCR process. Cycle times of 6s or less are shown to be feasible, yielding benefits in time saved for multiple amplifications. Finally, the analysis is also used to identify the dimensionless parameters which govern the thermal characteristics of the device, illustrating the importance of the Biot number.
Intra‐arterial combination therapy for experimental acute ischemic stroke (2021)

Acute ischemic stroke continues to devastate millions of individuals worldwide. Current treatments work to restore blood flow but not rescue affected tissue. Our goal was to develop a combination of neuroprotective agents administered intra-arterially following recanalization to target ischemic tissue. Using C57Bl/6J male mice, we performed tandem transient ipsilateral middle cerebral/common carotid artery occlusion, followed by immediate intra-arterial pharmacotherapy administration through a standardized protocol. Two pharmacotherapy agents, verapamil and lubeluzole, were selected based on their potential to modulate different aspects of the ischemic cascade; verapamil, a calcium channel blocker, works in an acute fashion blocking L-type calcium channels, whereas lubeluzole, an N-methyl-D-aspartate modulator, works in a delayed fashion blocking intracellular glutamate trafficking. We hypothesized that combination therapy would provide complimentary and potentially synergistic benefit treating brain tissue undergoing various stages of injury. Physiological measurements for heart rate and pulse distention (blood pressure) demonstrated no detrimental effects between groups, suggesting that the combination drug administration is safe. Tissue analysis demonstrated a significant difference between combination and control (saline) groups in infarct volume, neuronal health, and astrogliosis. Although a significant difference in functional outcome was not observed, we did note that the combination treatment group had a greater percent change from baseline in forced motor movement as compared with controls. This study demonstrates the safety and feasibility of intra-arterial combination therapy following successful recanalization and warrants further study.
Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12 (2018)

Adoptive T cell therapy (ACT) is a promising new modality for malignancies. Here, we report that adoptive T cell efficacy in tumor-bearing mice is significantly affected by differences in the native composition of the gut microbiome or treatment with antibiotics, or by heterologous fecal transfer. Depletion of bacteria with vancomycin decreased the rate of tumor growth in mice from The Jackson Laboratory receiving ACT, whereas treatment with neomycin and metronidazole had no effect, indicating the role of specific bacteria in host response. Vancomycin treatment induced an increase in systemic CD8α+ DCs, which sustained systemic adoptively transferred antitumor T cells in an IL-12-dependent manner. In subjects undergoing allogeneic hematopoietic cell transplantation, we found that oral vancomycin also increased IL-12 levels. Collectively, our findings demonstrate an important role played by the gut microbiota in the antitumor effectiveness of ACT and suggest potentially new avenues to improve response to ACT by altering the gut microbiota.
First small-animal in-vivo phase-contrast micro-CT scanner (2012)

We have developed a compact grating-based in-vivo phase-contrast micro-CT system with a rotating gantry. The 50 W microfocus x-ray source operates with 20 to 50 kV peak energy. The length of the rotating interferometer is around 47 cm. Pixel size in the object is 30 micron; the field of view is approx. 35 mm in diameter, suited to image a mouse. The interferometer consists of three gratings: an absorption grating close to the x-ray source, a phase grating to introduce a &pi;/2 phase shift and an absorption analyzer grating positioned at the first fractional Talbot distance. Numerous drives and actuators are used to provide angular and linear grating alignment, phase stepping and object/gantry precision positioning. Phantom studies were conducted to investigate performance, accuracy and stability of the scanner. In particular, the influences of gantry rotation and of temperature fluctuations on the interferometric image acquisition were characterized. Also dose measurements were performed. The first imaging results obtained with the system show the complementary nature of phase-contrast micro-CT images with respect to absorption-based micro-CT. Future improvements, necessary to optimize the scanner for in-vivo small-animal CT scanning on a regular and easy-to-use basis, are also discussed.
A 10-s doping technology for the application of low-temperature polysilicon TFTs to giant microelectronics (1993)

A bucket-type high-density (0.25-1.2-mA/cm/sup 2/) low-energy (500-2000 V) ion source was utilized for high-speed phosphorus doping directly into a thin polysilicon layer without cap SiO/sub 2/. Doping gas with He dilution was selected to reduce etching of polysilicon film. Excimer laser (XeCl, 8 mm*8 mm) pulse annealing was introduced to activate effectively the doped impurity. The combination of these techniques provided a practically low sheet resistance for the TFT source, drain, and gate with a short time doping. The low-temperature polysilicon TFT fabricated with a doping time of 10 s had characteristics comparable to those of that fabricated by a longer time doping or conventional ion implantation, showing the practicality of this technology and its promise for giant microelectronics.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity (2017)

ICOS costimulation generates Th17 cells with durable memory responses to tumor. Herein, we found that ICOS induces PI3K/p110δ/Akt and Wnt/β-catenin pathways in Th17 cells. Coinhibiting PI3Kδ and β-catenin altered the biological fate of Th17 cells. Th17 cells inhibited of both pathways expressed less RORγt, which, in turn, reduced their ability to secrete IL-17. Unexpectedly, these cells were more effective (than uninhibited cells) at regressing tumor when infused into mice, leading to long-term curative responses. PI3Kδ inhibition expanded precursor Th17 cells with a central memory phenotype that expressed nominal regulatory properties (low FoxP3), while β-catenin inhibition enhanced Th17 multifunctionality in vivo. Remarkably, upon TCR restimulation, RORγt and IL-17 rebounded in Th17 cells treated with PI3Kδ and β-catenin inhibitors. Moreover, these cells regained β-catenin, Tcf7, and Akt expression, licensing them to secrete heightened IL-2, persist, and eradicate solid tumors without help from endogenous NK and CD8 T cells. This finding shines a light on ways to repurpose FDA-approved drugs to augment T cell-based cancer immunotherapies.
Oxidation and Reduction (2007)

This chapter contains sections titled: Oxidation by Metal Ions Oxidation by Compounds of Non-metallic Elements Ozonolysis and Ozonation Peracids, Peroxides, and Super-oxide Atomic Oxygen and Singlet Oxygen Autoxidation and Other Reactions of Triplet Oxygen Miscellaneous Oxidations Reduction by Complex Hydrides Reduction by Metals, Metal Complexes, and Ions Miscellaneous Reductions Hydrogenation Reductions and Oxidations of Biological Interest
Correction: EBV induces persistent NF-κB activation and contributes to survival of EBV-positive neoplastic T- or NK-cells (2017)

[This corrects the article DOI: 10.1371/journal.pone.0174136.].
Novel Pressure-sensitive Bonding Tape in the Three-dimensional Chip Stacking (2006)

半導体集積回路形成済みチップの積層に用いるペースト状接着剤に起因する問題の解決と半導体製造プロセスを簡略する目的で，アクリル酸エステル共重合体，紫外線硬化型樹脂およびエポキシ樹脂からなる粘接着剤を開発した。紫外線硬化型樹脂の添加量および紫外線照射光量が過剰になると接着物性は低下することがわかった。一方，メタクリル酸グリシジルをアクリル酸エステル共重合体中に含み，エポキシ樹脂として多官能ノボラック型エポキシ樹脂を用いることにより良好な接着性および耐熱性が得られた。本テープは紫外線硬化と加熱硬化を段階的に行うことにより，汎用のダイシングテープならびにペースト状接着剤より優れた性能を示し，ダイシング機能とチップ接合能を兼備した全く新しい半導体製造用粘接着剤に成り得ることがわかった。