gebhart/patrepeval huggingface dataset:
Re: Detrusor Overactivity is Associated With Downregulation of Large-Conductance Calcium- and Voltage-Activated Potassium Channel Protein (2010)

No AccessJournal of UrologyInvestigative Urology1 Jan 2011Re: Detrusor Overactivity is Associated With Downregulation of Large-Conductance Calcium- and Voltage-Activated Potassium Channel Protein Anthony AtalaM.D. Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.09.056AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Detrusor Overactivity is Associated With Downregulation of Large-Conductance Calcium- and Voltage-Activated Potassium Channel Protein." The Journal of Urology, 185(1), pp. 352–353 © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 1January 2011Page: 352-353 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF DownloadLoading ...
Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile (2013)

Homologous recombination repair (HRR) protects cells from the lethal effect of spontaneous and therapy-induced DNA double-stand breaks. HRR usually depends on BRCA1/2-RAD51, and RAD52-RAD51 serves as back-up. To target HRR in tumor cells, a phenomenon called "synthetic lethality" was applied, which relies on the addiction of cancer cells to a single DNA repair pathway, whereas normal cells operate 2 or more mechanisms. Using mutagenesis and a peptide aptamer approach, we pinpointed phenylalanine 79 in RAD52 DNA binding domain I (RAD52-phenylalanine 79 [F79]) as a valid target to induce synthetic lethality in BRCA1- and/or BRCA2-deficient leukemias and carcinomas without affecting normal cells and tissues. Targeting RAD52-F79 disrupts the RAD52-DNA interaction, resulting in the accumulation of toxic DNA double-stand breaks in malignant cells, but not in normal counterparts. In addition, abrogation of RAD52-DNA interaction enhanced the antileukemia effect of already-approved drugs. BRCA-deficient status predisposing to RAD52-dependent synthetic lethality could be predicted by genetic abnormalities such as oncogenes BCR-ABL1 and PML-RAR, mutations in BRCA1 and/or BRCA2 genes, and gene expression profiles identifying leukemias displaying low levels of BRCA1 and/or BRCA2. We believe this work may initiate a personalized therapeutic approach in numerous patients with tumors displaying encoded and functional BRCA deficiency.
Fluid Film Thickness Measurement with Moiré Fringes (1972)

A mathematical analysis of the application of moiré fringe contouring to fluid film thickness measurement is made. Two special cases are treated. The first considers the generation of contours with a collimated light source and distant observer. The second analyzes the fringe patterns viewed by an observer near the grid when there is a point source of light. Geometrical restrictions imposed on the experimental setup are detailed. Experimental results are included.
Identification and fine mapping of a major QTL (qRtsc8-1) conferring resistance to maize tar spot complex and validation of production markers in breeding lines (2022)

A major QTL of qRtsc8-1 conferring TSC resistance was identified and fine mapped to a 721 kb region on chromosome 8 at 81 Mb, and production markers were validated in breeding lines. Tar spot complex (TSC) is a major foliar disease of maize in many Central and Latin American countries and leads to severe yield loss. To dissect the genetic architecture of TSC resistance, a genome-wide association study (GWAS) panel and a bi-parental doubled haploid population were used for GWAS and selective genotyping analysis, respectively. A total of 115 SNPs in bin 8.03 were detected by GWAS and three QTL in bins 6.05, 6.07, and 8.03 were detected by selective genotyping. The major QTL qRtsc8-1 located in bin 8.03 was detected by both analyses, and it explained 14.97% of the phenotypic variance. To fine map qRtsc8-1, the recombinant-derived progeny test was implemented. Recombinations in each generation were backcrossed, and the backcross progenies were genotyped with Kompetitive Allele Specific PCR (KASP) markers and phenotyped for TSC resistance individually. The significant tests for comparing the TSC resistance between the two classes of progenies with and without resistant alleles were used for fine mapping. In BC<sub>5</sub> generation, qRtsc8-1 was fine mapped in an interval of ~ 721 kb flanked by markers of KASP81160138 and KASP81881276. In this interval, the candidate genes GRMZM2G063511 and GRMZM2G073884 were identified, which encode an integral membrane protein-like and a leucine-rich repeat receptor-like protein kinase, respectively. Both genes are involved in maize disease resistance responses. Two production markers KASP81160138 and KASP81160155 were verified in 471 breeding lines. This study provides valuable information for cloning the resistance gene, and it will also facilitate the routine implementation of marker-assisted selection in the breeding pipeline for improving TSC resistance.
The interaction of sodium nitroprusside with human endothelial cells and platelets: nitroprusside and prostacyclin synergistically inhibit platelet function. (1982)

Sodium nitroprusside (NP) is a potent vasodilator that also inhibits platelet aggregation. To test the hypothesis that NP causes both of these effects by altering the balance between prostacyclin (PGI2) produced by endothelial cells and thromboxane A2 (TXA2) produced by platelets, we incubated each of these cell types with NP for 5 minutes and assayed the PGI2 and TXA2 produced. NP at pharmacologically achieved doses (0.01--30 micrograms/ml) inhibited platelet aggregation and resultant TXA2 synthesis in a dose- and time-dependent manner (p less than 0.001). The inhibition was not dependent on cAMP production, external calcium concentration, or suppression of TXA2 synthesis. NP did not alter the production of PGI2 by cultured human endothelial cells as measured by radioimmunoassay for 6-Keto-PGF1 alpha, the stable hydrolysis product of PGI2. However, supernates of NP-treated endothelial cells containing low, noninhibitory concentrations of NP unexpectedly inhibited platelet aggregation. This inhibition of platelet aggregation was due to synergy between PGI2 (0.1--3 nM) and NP (p interaction less than 0.03). The synergistic inhibition by NP and PGI2 of platelet aggregation and TXA2 synthesis in vivo may explain some of the beneficial actions of NP in the treatment of hypertension and congestive heart failure.
Optically bistable photonic crystal device for optics integration (2003)

Using an analytical theory and detailed computational experiments, we design a Kerr-nonlinear photonic crystal device, operating at mW power levels, which is particularly suitable for optics integration.
C-MHAD: Continuous Multimodal Human Action Dataset of Simultaneous Video and Inertial Sensing (2020)

Existing public domain multi-modal datasets for human action recognition only include actions of interest that have already been segmented from action streams. These datasets cannot be used to study a more realistic action recognition scenario where actions of interest occur randomly and continuously among actions of non-interest or no actions. It is more challenging to recognize actions of interest in continuous action streams since the starts and ends of these actions are not known and need to be determined in an on-the-fly manner. Furthermore, there exists no public domain multi-modal dataset in which video and inertial data are captured simultaneously for continuous action streams. The main objective of this paper is to describe a dataset that is collected and made publicly available, named Continuous Multimodal Human Action Dataset (C-MHAD), in which video and inertial data stream are captured simultaneously in a continuous way. This dataset is then used in an example recognition technique and the results obtained indicate that the fusion of these two sensing modalities increases the F1 scores compared to using each sensing modality individually.
H2S-sensitive thin film fabricated from hydrothermally synthesized SnO2 sol (1994)

A porous thin film of SnO2 prepared on an alumina substrate by using hydrothermally synthesized SnO2 sol shows excellent sensitivity to dilute H2S in air together with good response transient characteristics when calcined at 700 °C. The pore size of the film increases uniformly with calcination temperature, and this well developed porous structure appears to be responsible for the excellent H2S sensing characteristics.
Preference for Sensory Consonance in 2- and 4-Month-Old Infants (2002)

The preferences of 2- and 4-month-old infants for consonant versus dissonant two-tone intervals was tested by using a looking-time preference procedure. Infants of both ages preferred to listen to consonant over dissonant intervals and found it difficult to recover interest after a sequence of dissonant trials. Thus, sensitivity to consonance and dissonance is found before knowledge of scale structure and may be based on the innate structure of the inner ear and the firing characteristics of the auditory nerve. It is likely that consonance perception provides a bootstrap into the task of learning the pitch structure of the musical system to which the infant is exposed.
Strategies for Low-Temperature Liquid Organic Hydrogen Carrier Dehydrogenation (2021)

Liquid organic hydrogen carriers (LOHCs) store hydrogen by covalent bonds in a safe and dense manner. Recovery of hydrogen is realized by an endothermal dehydrogenation reaction. Theoretically, its heat demand could be covered by waste heat, e.g., from a fuel cell. However, to facilitate this, it is crucial to increase the temperature level of polymer electrolyte membrane fuel cells and lower the temperature level of the dehydrogenation reaction. In this study, strategies for releasing hydrogen from LOHCs at low temperatures are presented and evaluated. Thereby, the focus is on approaches for overcoming limitations by the reaction equilibrium. We see three main options: (i) dehydrogenation at a low pressure, (ii) dilution of hydrogen with an inert gas, and (iii) reactive distillation. These options are examined, particularly regarding their suitability for integrating waste heat, e.g., from fuel cells. Low-pressure dehydrogenation and reactive distillation show the highest potential for realizing efficient low-temperature hydrogen release.
Temporal patterns of stromelysin‐1, tissue inhibitor, and proteoglycan fragments in human knee joint fluid after injury to the cruciate ligament or meniscus (1994)

Stromelysin-1, tissue inhibitor of metalloproteinases-1 (TIMP-1), and proteoglycan fragments were quantified in knee synovial fluid samples in a cross-sectional study of patients who had injury to the anterior cruciate ligament or the meniscus. The average concentrations of stromelysin-1 and TIMP-1 increased 25-fold and 10-fold within the first day after the trauma, respectively, and the concentration of proteoglycan fragments increased 4-fold. From approximately 1-6 months after injury, the levels of these markers were higher after injury to the cruciate ligament than after injury to the meniscus. From 6 months to 18 years after trauma, however, the levels of stromelysin-1 and TIMP-1 in patients who had an injury to the ligament were the same as the levels in patients who had a meniscal lesion, but the levels were increased compared with those for a reference group of healthy volunteers. The molar balance of stromelysin-1 to TIMP-1 in synovial fluid in both groups of injured joints changed from a balance representing an excess of free inhibitor in the normal joint to one representing an excess of free enzyme in the injured joint. The increased release of these markers to joint fluid both early and late after trauma may be caused by a change in the loading patterns in the knee with an injured ligament or meniscus or by synovitis induced by bleeding. The increased release may be associated with the frequent development of posttraumatic osteoarthritis in patients with these injuries.
Options for Silicon Based Modulators (2013)

This papers provides an overview of modulators developed in the projects “HELIOS”, and “UK Silicon Photonics”, projects. We report low power cascaded modulators, integration with a modulator driver via wire bonding and via integration with BiCMOS technology.
RateGuard: A Robust Distributed Denial of Service (DDoS) Defense System (2009)

One of the major threats to cyber security is the distributed denial-of-service (DDoS) attack. In this paper, we focus on three kinds of sophisticated DDoS attacks that seriously cripple the current DDoS defense systems and have not been solved yet. In fast adaptive attacks (FAAs), attackers adaptively generate attacking traffic based on the feedback from a victim in round trip time (RTT). Almost all proposed rules-based filtering schemes cannot effectively defend against FAAs, since they need a relatively long time (compared to RTT) to update filtering rules. In adaptive attacks with statistical filtering rules scanning (AAS), attackers circumvent the defense system by discovering the statistical filtering rules of the defense system and then generating flooding traffic to mimic nominal traffic. In low rate TCP attacks (LRAs), attackers send periodic attack pulses to overflow a router's buffer and force the legitimate TCP flow to a low throughput while staying under the radar with a very low average rate. In this paper, we propose a leaky-bucket (LB) based highly robust DDoS defense system, called RateGuard. It can react to FAAs and LRAs by rate-limiting excessive traffic in real-time according to the victim's nominal traffic profile. Moreover, by associating an LB with each joint attribute value, the huge space required for possible joint attribute values makes it almost impossible for attackers to scan the victim's nominal traffic profiles and, thus, makes it highly robust to cope with AAS and other sophisticated attacks.
Analysis of Vitamin C (ascorbic acid) Contents in Various Fruits and Vegetables by UV-spectrophotometry (1970)

Total vitamin C (ascorbic acid + dehydroascorbic acid) has been determined by UVspectrophotometric method in various fruits and vegetables. In this method bromine water oxidizes ascorbic acid to dehydroascorbic acid in presence of acetic acid. After coupling with 2,4-dinitrophenyl hydrazine at 37&amp;deg:C temperature for three hours, the solution is treated with 85% H2SO4 to produce a red color complex and the absorbance was spectrophotometrically measured at 521 nm. The content of vitamin C were 10 mg/100g to 80 mg/100g in fruits and 16 mg/100g to 42 mg/100g in vegetables. Aloss of 64% at -10°C and 76% at 5°C was observed after two months storage period of one leafy vegetable "Enhydra fluctuans" (Helencha shak). Key words: Vitamin C determination, Vegetables, Fruits, UV-spectrophotometer.
Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides (2016)

A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.
Intestinal uptake of hexoses and fatty acids in tumor-bearing rats. (1985)

An in vitro technique was used to examine the rate of uptake of varying concentrations of glucose, galactose, and a homologous series of saturated fatty acids into the jejunum of control rats and Noble rats bearing prostatic tumor variants of primary human prostatic adenocarcinoma 52. Both groups of animals were healthy, eating and gaining weight normally. The uptake of acetic and butyric acid was reduced in tumor-bearing rats, but the uptake of four medium chain-length fatty acids was unchanged. The similar value of the incremental change in free energy in the control and tumor-bearing animals indicates similar passive permeability properties of the jejunum in the two groups. The uptake of varying concentrations of glucose and galactose was similar in the control and in the tumor-bearing animals. It is concluded that there are only subtle changes in nutrient uptake in tumor-bearing rats that are eating and gaining weight normally. It is suggested that any alteration in nutrient absorption which might occur in the cachectic tumor-bearing animal is probably due to alterations in food intake or body weight, rather than due to a direct effect of the tumor on the intestine.
Searching for Speech in Personal Audio (2005)

Personal Audio, as might be collected by a continuously-recording flash-memory recorder worn on the body, presents an exciting frontier for search and access to details of an individual user’s daily activity. An MP3 player able to make such recordings ‐ weighing a couple of ounces and able to record for over 10 hours on a single AA battery ‐ can be bought today for under $100, but, while there is surely valuable information available in the complete soundtrack to one’s daily experiences, no tools currently exist to make such recordings remotely useful ‐ since finding some event of interest entails review of minutes or hours of raw recordings. As part of a broader research project to investigate this modality and to develop search and retrieval mechanisms for it, we have identified detecting the absence or presence of speech as important attribute to take us towards a useful search mechanism for these data. This document proposes a project to develop an approach to identifying segments of speech in such recordings, which differ from the usual domain of speech detection (e.g. telephone calls) by the wide range of environments encountered (e.g. reverberation) and the very poor signal-to-noise ratios at which target speech would still be identified by a human listener (for instance, when engaged in a conversation in a busy restaurant). Our approach seeks to copy part of what listeners may be doing, by keying in to the pitch of a target listener and recognizing characteristically ‘speechy’ patterns of pitch and energy (prosodic) variation.
Fission-Product Separation Based on Room-Temperature Ionic Liquids (OR08SP24-16) (2002)

The objectives of this project are (a) to synthesize new ionic liquids tailored for the extractive separation of Cs + and Sr 2+; (b) to select optimum macrocyclic extractants through studies of complexation of fission products with macrocyclic extractants and transport in new extraction systems based on ionic liquids; (c) to develop efficient processes to recycle ionic liquids and crown ethers; and (d) to investigate chemical stabilities of ionic liquids under strong acid, strong base, and high-level-radiation conditions.
GOL-PET experiments on THZ-emission from dense plasma at relativistic electron beam relaxation (2015)

Summary form only given. Electromagnetic emission from plasma in the vicinity of the fundamental plasma frequency and at its double value during a relativistic electron beam (REB) relaxation is studied at the GOL-3 facility [1]. In our paper we will present results of experiments carried out on the specialized GOL-PET device for the emission of terahertz radiation from plasma at its density ~ 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">15</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> and the magnetic field strength 2-4 T. The plasma column created by a high-voltage discharge in the GOL-PET device has its diameter 6 cm and the length about of 250 cm. The injected electron beam has the following parameters: ~0.8 MeV, ~20 kA, ~10 μs. The beam current density in the plasma is up to 3kA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The radiation in the frequency interval from 0.1 up to 0.8 THz is analyzed by fast eight-channel polychromator and polarimeter based on frequency selection quasioptical elements.Results of the experimental measurements will be discussed in accordance to theoretical description with taking into account the influence of the magnetic field and high level turbulent in the plasma [2].
Rethinking staging and treatment for renal cell cancer. (2001)

The treatment of metastatic renal cell carcinoma (RCC) has dramatically evolved in recent years. The role of immunotherapy for the treatment of patients with metastatic disease has been firmly established. However, the role of adjuvant immunotherapy for high-risk patients with locally aggressive or nodal disease in the absence of distant metastasis is unclear. Moreover, the tumor-node-metastasis (TNM) staging for RCC was revised in 1997, and the impact of this revision of prognostication has not been well studied. Studies that address these two issues are reviewed.
Potential Use of Autologous Renal Cells from Diseased Kidneys for the Treatment of Renal Failure (2019)

George, Sunil PhD; Jackson, John D. PhD; Atala, Anthony MD, FACS; Yoo, James J. MD, PhD Author Information