gebhart/patrepeval huggingface dataset:
Effect of Prelube, Surface Coating and Substrate Materials on Initial Strength of Adhesive Joints Between Al Alloy and Steels (2011)

Growing usage of lightweight materials such as Al and Mg alloys in automotive body manufacture has come to a point that bonding of dissimilar materials is a realistic problem to address. A significant issue related to the bonding of dissimilar materials is that the differences in substrate surface conditions and substrate strengths often lead the bond to fail at strength far less than the bond strength established by adhesive manufacturer for a balanced joint. This research experimentally studied several factors potentially influencing initial strengths and debonding modes of adhesively-bonded Al-steel joints using single lap-shear coupons with comparison to like-substrate joints. Three commonly-used SLS coupon fabricating processes were investigated to determine which provided consistent bond strength and was efficient in making large quantities of coupons for the subsequent study. Next, the effect of prelube on the initial bond strength and debonding mode was investigated since the amount of prelube varies from sheet to sheet in automotive production. It was observed that even a very small change in the amount of prelube being applied on Al affected the initial bond strength. The more the prelube the weaker the bond became and the more adhesive failure occurred on the bonded Al surface. On the other hand, varying amount of the mill oil on the steel surface did not make much change to the bonding strength. Finally, various combinations of Al and steel substrates were studied to observe the effect of substrate materials on the initial bond strength and failure behavior. It revealed that the strength of joints between a relatively strong substrate and a relatively weak substrate fell below the strength of identical material joint made of the relatively strong substrate, and was closer to the strength of identical material joint made of the relatively weak substrate. For bonds having a high joint efficiency, adhesive failures were observed mostly on the surfaces of relatively weak substrates in the dissimilar material bonds due to large deformation in the weak substrate resulting in higher loading on that interface.
O-serotype distribution of Escherichia coli bloodstream infection isolates in critically ill patients in The Netherlands (2021)

A multi-valent ExPEC O-polysaccharide conjugate vaccine in development could potentially aid in the prevention of E. coli BSI in Dutch ICU patients.
(Invited) In Memoriam Ulrich Gösele: Wafer Bonding à la Carte (2010)

The modern day wafer bonding is inspired by the pioneering work of Prof. Dr. Ulrich Gösele in science and technology of direct bonding. Gösele's research helped in understanding of the fundamental mechanisms and thus revealing the technological interest of this technology. The paper reviews the results of basic studies in the area of wafer direct bonding of semiconductor and ferroelectric materials. Recent advances of the wafer bonding technology for the fabrication of advanced engineered substrates and 3D stacking are discussed.
Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear (1996)

The latency-associated transcripts (LATs) of herpes simplex virus type 1 (HSV-1) are the only viral gene products that accumulate to abundant levels in latently infected cells. Others have reported species of 2.0, 1.50, and 1.45 kb; only the 2.0-kb species is seen in productively infected cells, and there is evidence that it behaves as an intron. We examined the LATs both in trigeminal ganglia of latently infected mice and in productively infected cultures of monkey CV-1 cells. After glyoxalation, RNA was subjected to high-resolution agarose gel electrophoresis and Northern (RNA) analysis, a procedure capable of resolving linear and nonlinear RNA species. Under these conditions, we resolved the 2.0-kb LAT into two species; the slower species was much more abundant and had a mobility significantly slower than expected for a linear RNA. To test the hypothesis that this RNA was in fact nonlinear, we used partial hydrolysis by sodium carbonate and oligonucleotide-directed RNase H digestion. These procedures changed the mobility of the slower species into that of the faster species. Similarly, the mobility of the 1.50-kb LAT, which was much more abundant than the 1.45-kb LAT, was changed by these procedures to that of the 1.45-kb LAT. Our data show that the two major LAT species are nonlinear, and they support an interpretation of stable lariat structures.
ChemInform Abstract: Synthesis and Antitumor Activity of 9‐Acyloxyellipticines. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
GSI'17 Opening session (2017)

Geometric Science of Information SEE/SMF GSI’17 Conference Mines ParisTech GSI’17 General Chairmen: Frederic BARBARESCO*, Frank NIELSEN** & Silvere BONNABEL*** (*) President of SEE ISIC Club (Ingenierie des Systemes d’Information de Communications) (**) LIX Department, Ecole Polytechnique, (***) CAOR Lab, Mines ParisTech, Societe de l'electricite, de l'electronique et des technologies de l'information et de la communication GSI’13 Mines ParisTech GSI’15 Ecole Polytechnique Slides: https://www.see.asso.fr/gsi2013 Videos: https://www.youtube.com/channel/UC5HHo1jb QXusNQzU1iekaGA UNITWIN website (slides & videos): http://forum.cs-dc.org/category/90/gsi2015 Hirohiko Shima Jean-Louis Koszul Charles-Michel Marle GSI’13 Mines GSI’15 Polytechnique Roger Balian ORBITUARY Michel Marie Deza died on 23 november 2016 in an accidental fire in his apartment in Paris. He was a Soviet and French mathematician, specializing in combinatorics, discrete geometry and graph theory.He was director of research at the French National Centre for Scientific Research (CNRS), the vice president of the European Academy of Sciences, a research professor at the Japan Advanced Institute of
Species and dose dependence of ion implantation damage induced transient enhanced diffusion (1996)

The implant species and dose effects of ion implantation, including crossing the amorphization threshold, on the transient enhanced diffusion (TED) behavior of a boron marker layer in silicon have been studied. It has been found that for lower implant doses, TED is species independent. However, for higher implanted doses, the dependence of TED on species becomes very significant. It has been found that at these higher doses, including amorphizing doses, P implants cause more TED than either Si or As implants. This result is explained based on the fully coupled diffusion mechanism of the impurity dopants where dopants diffuse by temporarily pairing with point defects. Additionally, both point defect clusters and extended defects such as dislocations significantly affect the dopant profile evolution of both the implanted profile and the buried marker layer. By modeling these effects, the experimental results have been simulated and a consistent parameter set has been found to fit the data to a reasonable extent.
Convallatoxin-Induced Reduction of Methionine Import Effectively Inhibits Human Cytomegalovirus Infection and Replication (2016)

Cytomegalovirus is a highly prevalent virus capable of causing severe disease in certain populations. The current FDA-approved therapeutics all target the same stage of the viral life cycle and induce toxicity and viral resistance. We identified convallatoxin, a novel cell-targeting antiviral that inhibits CMV infection by decreasing the synthesis of viral proteins. At doses low enough for cells to tolerate, convallatoxin was able to inhibit primary isolates of CMV, including those resistant to the anti-CMV drug ganciclovir. In addition to identifying convallatoxin as a novel antiviral, limiting mRNA translation has a dramatic impact on CMV infection and proliferation.
Some Examples of Cyclic Vectors in the Dirichlet Space (1985)

We consider the Hilbert space of analytic functions in the open unit disc that have a finite Dirichlet integral. For $E$, a closed subset of the unit circle with logarithmic capacity zero, we construct a function in this space which is uniformly continuous, vanishes on $E$, and is cyclic with respect to the shift operator.
Study on extension to higher frequency band of 3GPP Outdoor-to-Indoor path loss model (2015)

Recently, mobile communication system for the 5th generation (5G) has been extensively investigated to satisfy the need for high-speed and high-capacity communication. In order to realize the higher and larger data communication, one of the approaches is to utilize high frequencies such as high SHF (above 6 GHz) and EHF (30–100 GHz) [1]. These frequency bands are expected to be applied for outdoor or indoor small cell; hence it is critically important to investigate the characteristics of propagation and model it. Additionally, characteristics of ‘Outdoor-to-Indoor (O2I) propagation’ and its modelling are necessary from system design point of view. This report presents extensive investigation for Extension of 3GPP model below 6 GHz [2].
Gallbladder polyps in familial adenomatous polyposis (2017)

Introduction Familiar adenomatous polyposis (FAP) is an inherited autosomal dominant disease characterized by the development of hundreds to thousands of colorectal adenomas in young adults. If left untreated, the patients develop colorectal cancer by age of 40. This disorder is caused by germline mutation of the adenomatous polyposis coli (APC) gene located on the chromosome 5q21. FAP can be associated with occur of various extracolonic malignancies, especially ampullary adenocarcinoma. As well it has been described an association between FAP, thyroid cancer and biliary system neoplasia. We present a rare case of multifocal gallbladder polyps in association with familial adenomatous polyposis. Case report We present the case of a 39-year-old male patient with the FAP-Syndrome. He had undergone a total colectomy with ileoanal pouch reconstruction years ago. In the current history, he reported about chronic abdominal pain in the right upper abdomen with postprandial nausea. The clinical examination at the admission showed no palpable mass or tenderness in the abdomen. The laboratory tests were normal. Abdominal ultrasound showed four concrements and multiple small polyps. He underwent laparoscopic cholecystectomy. The postoperative course was uneventful. Results and conclusions The mucosal inspection at the histopathological examination showed more than 80 green polypoid lesions. Microscopically were classified tubular adenomas with mostly low–grade but focally with high-grade epithelial dysplasia cells. Their epithelium was predominantly of the biliary type. No invasive malignant cells have been described. Immunohistochemical staining with s-catenin showed strong positivity for cytoplasmic and nuclear expression. APC is closely connected to s-catenin and a nuclear expression comes along with s-catenin mutations. Nuclear staining has been described in adenocarcinomas and late adenomas with severe dysplasia. Take-home message FAP is the most common adenomatous polyposis syndrome characterized by the development of numerous colorectal adenomatous polyps. It is associated with greater risk of developing upper gastrointestinal malignancy or extraintestinal cancer. Due to previous reports and our conclusions, a simultaneous prophylactic cholecystectomy should be performed by FAP patients, who undergo colectomy, to eliminate the risk of gallbladder neoplasia.
Effects of Bovine Herpesvirus Type 1 Infection in Calves with Maternal Antibodies on Immune Response and Virus Latency (2000)

The presence of maternally derived antibodies can interfere with the development of an active antibody response to antigen. Infection of seven passively immunized young calves with a virulent strain of bovine herpesvirus type 1 (BHV-1) was performed to determine whether they could become seronegative after the disappearance of maternal antibodies while latently infected with BHV-1. Four uninfected calves were controls. All calves were monitored serologically for 13 to 18 months. In addition, the development of a cell-mediated immune response was assessed by an in vitro antigen-specific gamma interferon (IFN-gamma) production assay. All calves had positive IFN-gamma responses as early as 7 days until at least 10 weeks after infection. However, no antibody rise was observed after infection in the three calves with the highest titers of maternal antibodies. One of the three became seronegative by virus neutralization test at 7 months of age like the control animals. This calf presented negative IFN-gamma results at the same time and was classified seronegative by enzyme-linked immunosorbent assay at around 10 months of age. This calf was latently infected, as proven by virus reexcretion after dexamethasone treatment at the end of the experiment. In conclusion, this study demonstrated that BHV-1-seronegative latent carriers can be obtained experimentally. In addition, the IFN-gamma assay was able to discriminate calves possessing only passively acquired antibodies from those latently infected by BHV-1, but it could not detect seronegative latent carriers. The failure to easily detect such animals presents an epidemiological threat for the control of BHV-1 infection.
CONVERSION OF TYROSINE TO CATECHOLAMINES BY RAT BRAIN SLICES (1963)

Evidence is presented for the enzymatic conversion of tyrosine to DOPA and the catecholamines by rat brain slices in vitro. Conversion is favored by ATP and TPNH and inhibited by pyridoxal phosphate. The conversion is very much less than that found under comparable conditions with rat adrenal medulla slices and also differs in that, in brain slices, there is a greater increase in DOPA than in dopamine or noradrenaline.
Stimulation of the T3-T cell receptor-associated Ca2+ influx enhances the activity of the Na+/H+ exchanger in a leukemic human T cell line. (1985)

Three monoclonal antibodies reactive with different structural domains of the T3-T cell receptor complex of the human T cell leukemia line, HPB-ALL, were previously shown to activate a membrane potential-sensitive, La3+-inhibitable Ca2+ influx (Oettgen, H. C., Terhorst, C., Cantley, L. C., and Rosoff, P. M. (1985) Cell 40, 583-590). OKT3 (anti-T3), WT-31 (anti-receptor constant region), and T40/25 (anti-receptor variable region) also enhance the activity of the Na+/H+ exchanger in these cells. The associated rise in pHi was dependent on the presence of external Ca2+ and Na+, was inhibited by dimethylamiloride and La3+, and was maintained for at least 20 min. Phorbol esters, which are co-mitogenic in T cells and activate protein kinase C, also stimulated the exchanger, but by a mechanism not requiring an elevation in cytoplasmic Ca2+; the rise in pHi rapidly peaked and returned to baseline levels within 20 min. Pretreatment with phorbols prevented an increase in pHi by OKT3 although a transient additive effect was observed when the two were added simultaneously. Receptor function was maintained in the presence of phorbol esters as OKT3 still stimulated a Ca2+ influx. These data demonstrate the existence of two interdependent pathways to activate Na+/H+ exchange in T lymphocytes and suggest a pathway of internal regulation of antigen-activated signal transduction.
Estimating amounts of iron oxide from gradient echo images (2009)

Rat legs directly injected with superparamagnetic iron oxide (SPIO) were studied by dual-echo, gradient-echo imaging. The amount of iron injected was estimated using a point dipole model for the SPIO injection site. Saturation magnetization of 6:1 PEG/amino modified silane-coated iron oxide particles with 5- to 6-nm core and 20-25 hydrodynamic diameter was approximately 110 emu/g of iron. Estimates of the amount of iron injected made from signal void volumes surrounding SPIO centers yielded erroneous results varying with sample orientation in the scanner and echo time (TE). For example, a 10 microL, 3-microg iron injection produced signal void volumes of 80 and 210 microL at TE of 9.8 and 25 ms, respectively, giving apparent iron contents of 6 +/- 1 and 10 +/- 2 microg respectively. A more effective approach uses the phase difference between two gradient recalled echo images. To estimate iron content, this approach fits the expected (3 cos(2)theta - 1)/(/r/3) spatial phase distribution to the observed phase differences. Extraneous phase effects made fitting phase at a single TE ineffective. With the dual echo method, 18 independent estimates were 2.48 +/- 0.26 microg std, independently of sample orientation. Estimates in empty control regions were -90 and -140 ng. A 1-microg injection indicated 0.5, 1.2, and 1.2 microg.
Feature integration and sensitivity to synchronicity for biological motion impaired by amblyopia (2010)

Spatio-temporal processing may be impaired in strabismic amblyopes (Asper et al., 2000; Popple & Levi, 2008; Roelfsema et al., 1994). The goals of this experiment were two-fold. First, we examined whether the amblyopic visual system retains the higher-level processing capabilities to detect biological motion. Second, we established whether synchronicity sensitivity (detection of synchronized versus desynchronized interactions) is impaired in amblyopic observers relative to normal control observers. We showed point-light displays generated from the trajectories of the major joints of two human agents performing a dancing routine. We used the method of constant stimuli to present the biological motion stimulus at five different stimulus levels, varying the strength of biological motion by varying the number of dot trajectories. Synchronized and desynchronized trials were randomly presented. Each trial consisted of two intervals, ‘target’ and ‘non-target’. In the non-target interval, the dot trajectories of one agent were scrambled. Observers were asked to indicate the target interval that showed two agents dancing. Our results show that the ability to detect biological motion requires more samples (dot trajectories) in both eyes of strabismic amblyopes than in normal control observers. The increased sample threshold is not the result of low-level losses (dot trajectories were visible) but may reflect losses in feature integration due to undersampling in the amblyopic visual system (Levi et al., 1987; Levi et al., 1999; Levi & Klein, 1986). However, like normal observers, amblyopes are more sensitive to synchronized versus desynchronized interactions, indicating that higher-level processing of biological motion remains intact, as previously reported (Neri et al., 2007; Thompson et al., 2008). In contrast, synchronicity sensitivity is impaired in the amblyopic visual system, because disruption due to desynchronization is especially strong. The presence or absence of binocular function may determine whether or not an observer possesses normal sensitivity to synchronicity.
Failure sketches: a better way to debug (2015)

One of the main reasons debugging is hard and time con-suming is that existing debugging tools do not provide an explanation for the root causes of failures. Addition-ally, existing techniques either rely on expensive runtime recording or assume existence of a given program input that reliably reproduces the failure, which makes them hard to apply in production scenarios. Consequently, de-velopers spend precious time chasing elusive bugs, re-sulting in productivity loss. We propose a new debugging technique, called fail-ure sketching, that provides the developer with a high-level explanation for the root cause of a failure. A failure sketch achieves this goal because: 1) it only contains pro-gram statements that cause a failure; 2) it shows which program properties differ between failing and successful executions. We argue that failure sketches can be built by combining in-house static analysis and crowdsourced dynamic analysis. For building a failure sketch, we do not assume that developers can reproduce the failure. We show preliminary evidence that failure sketches can sig-nificantly improve programmer productivity. 1
Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model (2017)

An early predictive molecular signature was identified that marked the active profibrotic process before histopathologic fibrosis becomes manifest. Early detection of the onset of NASH and fibrosis enables identification of novel blood-based biomarkers to stratify patients at risk, development of new therapeutics, and help shorten (pre)clinical experimental time frames.
P4‐397: RAISING AVAILABLE BRAIN CONCENTRATIONS OF A POTENTIAL ALZHEIMER’S DISEASE DRUG CANDIDATE BY PEPTIDE CYCLIZATION (2016)

Alzheimer’s disease (AD) is a widespread progressive neurodegenerative disease but to date, no curative treatment is established. To target toxic amyloid-beta (Aβ) species and to convert them into non-toxic species, we have developed and designed D-enantiomeric peptides. Here, we investigated if intraperitoneal and intravenous administration of a cyclic D-enantiomeric peptide (cycP) result in increased brain and plasma concentrations compared to the equivalent linear D-peptide (linP) which has been characterized before (Leithold et al., 2016). Furthermore, cycP’s pharmacokinetic profile, proteolytic stability and plasma protein binding properties were characterized to investigate whether cycP is a potential drug candidate. To determine cycP’s concentration-time-profile in murine plasma and brain, 3H-labelled peptide was administered intraperitoneally, intravenously and orally to wildtype mice (male C57BL/6N, 12 weeks). Proteolytic stability was investigated by thin layer chromatography after incubation for up to seven days in murine plasma, brain-homogenate and human liver microsomes. Plasma protein binding to human serum albumin (HSA) and α1-acid glycoprotein (AGP) was examined with TRANSIL Binding Kits. Four hours after intraperitoneal or intravenous administration, cycP concentrations in the brain were up to ten times higher than linP concentrations. In plasma, cycP concentrations were up to eight times higher. Furthermore, cycP showed longer half-life in plasma than linP. Oral cycP administration resulted in a constant concentration-time-profile. Brain concentrations of cycP after oral administration were even higher between 4 and 24 hours than those after i.p. or i.v. administration. Using thin layer chromatography we could show that cycP was not degraded within seven days. Plasma protein binding of cycP was stronger to AGP (dissociation constant [KD]: 1.2 μM, fraction unbound [fu]: 6 %) than to HSA (KD: 33 μM, fu: 5 %). As cycP concentrations in the brain were considerably higher than those of linP, cycP seems to pass the blood brain barrier (BBB) more efficiently than linP. This is fundamental for an Aß-targeting drug, as Aß is mainly found in AD-patients’ brains. In fact, an increased mobility to pass the BBB probably allows administration of lower doses for cycP treatment as compared to linP treatment, reducing further the risk of adverse side effects.