gebhart/patrepeval huggingface dataset:
A Single Integrated 3D‐Printing Process Customizes Elastic and Sustainable Triboelectric Nanogenerators for Wearable Electronics (2018)

Abstract Triboelectric nanogenerator (TENG) devices have gotten great attention in wearable power sources and physiological monitoring. However, the complicated assembling and the molding processing retard their applications. Here, 3D‐printed TENGs (3DP‐TENGs) are designed and readily fabricated by a single integrated process without additional assembling steps. The TENGs contain poly(glycerol sebacate) (PGS) and carbon nanotubes (CNTs) as the two electrification components. Conductive CNTs also serve as electrodes. Elastic PGS matrix makes TENGs intrinsically responsive to biomechanical motions leading to robust energy outputs. The hierarchical porous structure of the 3DP‐TENG results in higher output efficiency than traditional molded microporous TENG counterparts. TENGs with different 3D shapes are readily fabricated for different applications. The 3DP‐TENG insole efficiently harvests biomechanical energy to drive electronics. A ring‐shaped TENG acts as a self‐powered sensor to monitor the motion of fingers. Furthermore, the use of bio‐based and biodegradable PGS matrix combining with efficient recycle of CNTs makes 3DP‐TENGs favorable from sustainable perspective. This work provides a new strategy to design and tailor 3D TENGs that will be very useful for diverse electronic applications.
Supplementary Methods from Two Distinct Routes to Oral Cancer Differing in Genome Instability and Risk for Cervical Node Metastasis (2023)

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Transgenic A 1 adenosine receptor overexpression increases myocardial resistance to ischemia (1997)

Activation of myocardial A1 adenosine receptors (A1AR) protects the heart from ischemic injury. In this study transgenic mice were created using the cardiac-specific alpha-myosin heavy chain promoter and rat A1AR cDNA. Heart membranes from two transgene positive lines displayed approximately 1,000-fold overexpression of A1AR (6,574 +/- 965 and 10,691 +/- 1,002 fmol per mg of protein vs. 8 +/- 5 fmol per mg of protein in control hearts). Compared with control hearts, transgenic Langendorff-perfused hearts had a significantly lower intrinsic heart rate (248 beats per min vs. 318 beats per min, P < 0. 05), lower developed tension (1.2 g vs. 1.6 g, P < 0.05), and similar coronary resistance. The difference in developed tension was eliminated by pacing. Injury of control hearts during global ischemia, indexed by time-to-ischemic contracture, was accelerated by blocking adenosine receptors with 50 microM 8-(p-sulfophenyl) theophylline but was unaffected by addition of 20 nM N6-cyclopentyladenosine, an A1AR agonist. Thus A1ARs in ischemic myocardium are presumably saturated by endogenous adenosine. Overexpressing myocardial A1ARs increased time-to-ischemic contracture and improved functional recovery during reperfusion. The data indicate that A1AR activation by endogenous adenosine affords protection during ischemia, but that the response is limited by A1AR number in murine myocardium. Overexpression of A1AR affords additional protection. These data support the concept that genetic manipulation of A1AR expression may improve myocardial tolerance to ischemia.
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy (2021)

Factor XIa (FXIa) is an enzyme in the coagulation cascade thought to amplify thrombin generation but has a limited role in hemostasis. From preclinical models and human genetics, an inhibitor of FXIa has the potential to be an antithrombotic agent with superior efficacy and safety. Reversible and irreversible inhibitors of FXIa have demonstrated excellent antithrombotic efficacy without increased bleeding time in animal models (Weitz, J. I., Chan, N. C. <i>Arterioscler. Thromb. Vasc. Biol.</i> 2019, 39 (1), 7-12). Herein, we report the discovery of a novel series of macrocyclic FXIa inhibitors containing a pyrazole P2' moiety. Optimization of the series for (pharmacokinetic) PK properties, free fraction, and solubility resulted in the identification of <b>milvexian</b> (<b>BMS-986177/JNJ-70033093</b>, <b>17</b>, FXIa <i>K</i><sub>i</sub> = 0.11 nM) as a clinical candidate for the prevention and treatment of thromboembolic disorders, suitable for oral administration.
The Oncomine Cancer Research Panel, a scalable next-generation sequencing system for relevant somatic variant assessment in solid tumors. (2015)

e22164 Background: Next generation sequencing (NGS) has enabled genomewide personalized oncology efforts at centers and companies with the specialty expertise and infrastructure required for actionable variant identification and prioritization. Such approaches are not scalable, precluding widespread adoption. Methods: We conducted a comprehensive bioinformatics analysis and developed a knowledgebase of approved and investigational therapies to predefine the catalog of relevant solid tumor somatic genome variants (gain or loss of function mutations, high level copy number alterations, and gene fusions). To identify these variants, we developed the Oncomine Cancer Research Panel (OCP), which consists of amplicon based panels and an informatics pipeline for Ion Torrent NGS. OCP performance was assessed using molecular standards and formalin fixed paraffin embedded (FFPE) tumors. Results: Through integrating an analysis of over 700,000 cancer samples and a therapeutic knowledgebase, we designed the OCP, an Ion Torrent based NGS system compatible with < 20ng FFPE tissue isolated DNA/RNA. OCP validation using two different molecular standards demonstrated > 99% detection rate for known mutations (at near-expected variant frequencies). OCP assessment of over 300 FFPE tumor samples demonstrated > 95% sensitivity and specificity for KRAS, EGFR and BRAF mutation detection, as well as for ALK and TMPRSS2:ERGgene fusions. Associating positive variants with potential targeted treatments demonstrated that 642% of profiled tumor samples (depending on cancer type) harbored alterations beyond routine molecular testing that were associated with FDA approved or NCCN guideline-referenced therapies. Conclusions: By predefining somatic variants in solid tumors and compiling associated potential treatments and clinical trials, the OCP represents a simplified, broadly applicable targeted NGS system with the potential to advance precision oncology efforts.
LKB1/STK11 Suppresses Cyclooxygenase-2 Induction and Cellular Invasion through PEA3 in Lung Cancer (2006)

We showed that the PEA3 transcriptional factor interacted with LKB1, a serine/threonine kinase, which is somatically mutated in lung cancer. This interaction occurred through the ETS domain of PEA3 and the kinase domain of LKB1. Mutation of LKB1 in lung cancer cells stabilized PEA3. Reintroduction of wild-type (WT) LKB1 into cells induced down-regulation of PEA3 and subsequently resulted in reduced cyclooxygenase-2 RNA and protein expression, whereas germ-line and somatic LKB1 mutants were defective in this activity. LKB1 phosphorylated PEA3 and promoted its degradation through a proteasome-mediated mechanism. Cells expressing mutant LKB1 possessed greater invasive potential compared with cells expressing WT LKB1. Increased invasion of cells with mutant LKB1 was partly due to PEA3 expression, as RNA interference inhibition of PEA3 resulted in dramatic decrease of Matrigel invasion. However, forced expression of PEA3 resulted in down-regulation of epithelial markers and induction of mesenchymal markers. These results suggest that PEA3 stabilization due to LKB1 inactivation could lead to epithelial/mesenchymal transition and greater lung cancer invasion potential.
Changes in the Glycosylation of Kininogen and the Development of a Kininogen-Based Algorithm for the Early Detection of HCC (2017)

<b>Background:</b> Hepatocellular carcinoma (HCC) has the greatest increase in mortality among all solids tumors in the United States related to low rates of early tumor detection. Development of noninvasive biomarkers for the early detection of HCC may reduce HCC-related mortality.<b>Methods:</b> We have developed an algorithm that combines routinely observed clinical values into a single equation that in a study of >3,000 patients from 5 independent sites improved detection of HCC as compared with the currently used biomarker, alpha-fetoprotein (AFP), by 4% to 20%. However, this algorithm had limited benefit in those with AFP <20 ng/mL. To that end, we have developed a secondary algorithm that incorporates a marker, fucosylated kininogen, to improve the detection of HCC, especially in those with AFP <20 ng/mL and early-stage disease.<b>Results:</b> The ability to detect early-stage AFP-negative (AFP <20 ng/mL) HCC increased from 0% (AFP alone) to 89% (for the new algorithm). Glycan analysis revealed that kininogen has several glycan modifications that have been associated with HCC, but often not with specific proteins, including increased levels of core and outer-arm fucosylation and increased branching.<b>Conclusions:</b> An algorithm combining fucosylated kininogen, AFP, and clinical characteristics is highly accurate for early HCC detection.<b>Impact:</b> Our biomarker algorithm could significantly improve early HCC detection and curative treatment eligibility in patients with cirrhosis. <i>Cancer Epidemiol Biomarkers Prev; 26(5); 795-803. ©2017 AACR</i>.
Crystallinity and texture promotion in WS2 thin films (1997)

A systematic study of the promoting effect of various elements on crystallization and texture of tungsten sulfide (WS2) thin films is presented. Best crystallization at relatively low annealing temperatures Ta=650–750 °C is achieved by adding sodium sulfide or nickel to the film, while the strongest texture is achieved with cobalt. An improvement of crystallization and texture is equally achieved with iron, manganese, or cesium. The promoting effect is mostly independent of the way the promoter is added. The promoting element can be added as a thin layer on the substrate or on the top of the WS2 film or it can be codeposited with the WS2 film. Since rheotaxy models cannot satisfactorily explain these results, the possibility of a catalytic growth mechanism is discussed.
Poster: LuST-LTE: A simulation package for pervasive vehicular connectivity (2016)

Recent technological advances in communication technology have provided new ways to understand human mobility. Connected vehicles with their rising market penetration are particularly representative of this trend. They become increasingly interesting, not only as sensors, but also as participants in Intelligent Transportation System (ITS) applications. More specifically, their pervasive connectivity to cellular networks enables them as passive and active sensing units. In this paper, we introduce LuST-LTE, a package of open-source simulation tools that allows the simulation of vehicular traffic along with pervasive LTE connectivity.
Mori Folium water extract alleviates articular cartilage damages and inflammatory responses in monosodium iodoacetate-induced osteoarthritis rats (2017)

Mori folium, the leaf of Morus alba L. (Moraceae), has been widely used in traditional medicine for the treatment of various diseases. It has been recently reported that Mori folium possesses potential chondroprotective effects in interleukin (IL)‑1β‑stimulated human chondrocytes; however, its protective and therapeutic potential against osteoarthritis (OA) in an animal model remains unclear. In this study, as part of an ongoing screening program to evaluate the anti‑osteoarthritic potential of Mori folium, the protective effects of a water extract of Mori folium (MF) on cartilage degradation and inflammatory responses in a monosodium iodoacetate (MIA)‑induced OA rat model were evaluated. The results demonstrated that administration of MF had a tendency to attenuate the damage to articular cartilage induced by MIA, as determined by knee joint swelling and the histological grade of OA. The elevated levels of matrix metalloproteinases‑13 and two bio‑markers for the diagnosis and progression of OA, such as the cartilage oligomeric matrix protein and C‑telopeptide of type II collagen, were markedly ameliorated by MF administration in MIA‑induced OA rats. In addition, MF significantly suppressed the production of pro‑inflammatory cytokines, including IL‑1β, IL‑6 and tumor necrosis factor‑α. MF also effectively inhibited the expression of inducible nitric oxide (NO) synthase and cyclooxygenase‑2, thus inhibiting the release of NO and prostaglandin E2. Although further work is required to fully understand the critical role and clinical usefulness, these findings indicate that MF may be a potential therapeutic option for the treatment of OA.
Bioinformatics Describes Novel Loci for High Resolution Discrimination of Leptospira Isolates (2010)

As the first aim of our study, the ligB-secY-rpoB-lipL41 superlocus demonstrated a satisfactory level of discrimination among the strains evaluated. Second, the inclusion of the rpoB and lipL41 loci to a MLST scheme provided high resolution for discrimination of strains within L. interrogans and L. kirschneri and might be useful in future epidemiological studies.
APPLICATION OF NUCLEAR MAGNETIC RESONANCE (NMR) OF HYDROGEN TO THE STUDY OF PATHOLOGIC ANATOMY OF THE RAT (1980)

Herfkens, R. M.D.; Crooks, L. Ph.D.; Davis, P. M.D.; Margulis, A. R. M.D.; Hoenninger, J. M.S.; Arakawa, M. B.S.; Kaufman, L. Ph.D. Author Information
[Computer-assisted medicosurgical gestures]. (1993)

Computer assisted medical interventions (CAMI) aim at minimizing the invasive part of some medical or surgical techniques. This general objective is discussed, together with its scientific consequences. The general methodology of CAMI is then laid out, with special emphasis on its three fundamental steps: perception-reasoning-action. Each of these steps is illustrated with feasibility demonstrations in various domains. We then conclude by analysing the part this sort of technique could play in an hospital, together with the colaborations such a project implies.
Electromagnetic Interference and Implantable Devices (2008)

This chapter contains sections titled: Pacemaker responses to noise References
IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas (2018)

Systemic anaplastic large cell lymphomas (ALCL) are a category of T-cell non-Hodgkin's lymphomas which can be divided into anaplastic lymphoma kinase (ALK) positive and ALK negative subgroups, based on ALK gene rearrangements. Among several pathways aberrantly activated in ALCL, the constitutive activation of signal transducer and activator of transcription 3 (STAT3) is shared by all ALK positive ALCL and has been detected in a subgroup of ALK negative ALCL. To discover essential mediators of STAT3 oncogenic activity that may represent feasible targets for ALCL therapies, we combined gene expression profiling analysis and RNA interference functional approaches. A shRNA screening of STAT3-modulated genes identified interferon regulatory factor 4 (IRF4) as a key driver of ALCL cell survival. Accordingly, ectopic IRF4 expression partially rescued STAT3 knock-down effects. Treatment with immunomodulatory drugs (IMiDs) induced IRF4 down regulation and resulted in cell death, a phenotype rescued by IRF4 overexpression. However, the majority of ALCL cell lines were poorly responsive to IMiDs treatment. Combination with JQ1, a bromodomain and extra-terminal (BET) family antagonist known to inhibit MYC and IRF4, increased sensitivity to IMiDs. Overall, these results show that IRF4 is involved in STAT3-oncogenic signaling and its inhibition provides alternative avenues for the design of novel/combination therapies of ALCL.
IncucyteDRC: An R package for the dose response analysis of live cell imaging data (2016)

We present <i>IncucyteDRC</i>, an R package for the analysis of data from live cell imaging cell proliferation experiments carried out on the Essen Biosciences IncuCyte ZOOM instrument. The package provides a simple workflow for summarising data into a form that can be used to calculate dose response curves and EC50 values for small molecule inhibitors. Data from different cell lines, or cell lines grown under different conditions, can be normalised as to their doubling time. A simple graphical web interface, implemented using shiny, is provided for the benefit of non-R users. The software is potentially useful to any research group studying the impact of small molecule inhibitors on cell proliferation using the IncuCyte ZOOM.
Supplementary Data from Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2 (2023)

Supplementary Data from Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2
A 10.4 in.-diagonal full-colour TFT-LCD with new self-aligned a-Si TFTs for OHP system (2002)

A 10.4-in-diagonal full-color a-Si TFT-LCD (thin-film transistor liquid crystal display) for OHP (overhead projector) systems has been developed. The light degradation of LCD performance has been suppressed by new self-aligned a-Si TFTs and a new driving method (floating gate driving method). Both an ES (etching stopper)-SiN/sub x/ layer and a mu c-Si(n+)a-Si(i) layer were formed by the self-alignment technique. This structure is considered to be effective for decreasing the photocarrier injected into the gate-insulator. High stability under high intense light-exposure has been obtained. The driving method makes the difference of the potential between the gate and drain electrode constant. It improved the off characteristics and decreased the shift of the gate bias voltage transparency characteristics.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ChemInform Abstract: Antibacterial Agents. Part 9. The Aminomethylination of 3‐Methyl‐1‐(4‐ nitrophenyl)‐2‐pyrazolin‐5‐ones. (1987)

Abstract The pyrazolone (I) reacts with s‐triazine (II) to produce the adduct (III) which is converted to (IV) and (V) by further treatment with (II).
On Planar Discrete Elastic Rod Models for the Locomotion of Soft Robots (2019)

Modeling soft robots that move on surfaces is challenging from a variety of perspectives. A recent formulation by Bergou <i>et al.</i> of a rod theory that exploits new developments in discrete differential geometry offers an attractive, numerically efficient avenue to help overcome some of these challenges. Their formulation is an example of a discrete elastic rod theory. In this article, we consider a planar version of Bergou <i>et al.</i>'s theory and, with the help of recent works on Lagrange's equations of motion for constrained systems of particles, show how it can be used to model soft robots that are composed of segments of soft material folded and bonded together. We then use our formulation to examine the dynamics of a caterpillar-inspired soft robot that is actuated using shape memory alloys and exploits stick-slip friction to achieve locomotion. After developing and implementing procedures to prescribe the parameters for components of the soft robot, we compare our calibrated model to the experimental behavior of the caterpillar-inspired soft robot.
Pancreatic Neuroendocrine Tumor With Cystlike Changes: Evaluation With MDCT (2013)

Cystic pancreatic NETs are not rare and should be included in the differential diagnosis of a cystic pancreatic mass, particularly if the cystic mass is associated with peripheral contrast enhancement. A minority of cystic pancreatic NETs can present with no peripheral enhancement.
The CD16+ Monocyte Subset Is More Permissive to Infection and Preferentially Harbors HIV-1 In Vivo (2007)

HIV-1 persists in peripheral blood monocytes in individuals receiving highly active antiretroviral therapy (HAART) with viral suppression, despite these cells being poorly susceptible to infection in vitro. Because very few monocytes harbor HIV-1 in vivo, we considered whether a subset of monocytes might be more permissive to infection. We show that a minor CD16+ monocyte subset preferentially harbors HIV-1 in infected individuals on HAART when compared with the majority of monocytes (CD14highCD16-). We confirmed this by in vitro experiments showing that CD16+ monocytes were more susceptible to CCR5-using strains of HIV-1, a finding that is associated with higher CCR5 expression on these cells. CD16+ monocytes were also more permissive to infection with a vesicular stomatitis virus G protein-pseudotyped reporter strain of HIV-1 than the majority of monocytes, suggesting that they are better able to support HIV-1 replication after entry. Consistent with this observation, high molecular mass complexes of apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G) were observed in CD16+ monocytes that were similar to those observed in highly permissive T cells. In contrast, CD14highCD16- monocytes contained low molecular mass active APOBEC3G, suggesting this is a mechanism of resistance to HIV-1 infection in these cells. Collectively, these data show that CD16+ monocytes are preferentially susceptible to HIV-1 entry, more permissive for replication, and constitute a continuing source of viral persistence during HAART.
New Resveratrol Tetramers from the Stem Bark ofUpuna borneensis (2005)

Five new resveratrol (=5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol) tetramers, upunaphenols H-J (1-3) and trans-(4) and cis-upunaphenol K (5), were isolated from the stem of Upuna borneensis (Dipterocarpaceae). Their structures were elucidated on the basis of 1D- and 2D-NMR as well as FAB-MS data. Compounds 1-3 bear a rare biphenyl bond in their frameworks. Compounds 1 and 2 have an unprecedented nonacyclic fused ring system, and compounds 2 and 3 have symmetrical structures.
“Gated-diode” configuration in SOI MOSFET’s: A sensitive tool for evaluating the quality and reliability of the buried Si/SiO[sub 2] interface (2001)

A “gated-diode” configuration in SOI MOSFET’s is described, which is particularly suitable and easy to use for characterizing the buried oxide interface. This new approach becomes possible by taking advantage of the front gate, which is biased to inversion (NMOSFET’s) or accumulation (BC-PMOSFET’s) during the measurement. As a result, the drain merges with the inversion or accumulation layer and “extends” under the entire gate, forming a “horizontal” p-n junction with the channel. The drain-to-body diode is then forward-biased by a small voltage, and the back gate voltage is scanned such that it brings the back interface to depletion, a condition that is at the center of all gated-diode techniques and required to activate the interface states and start the recombination/generation processes. The mid-channel interface state density is obtained from the peak of the measured current vs. back gate voltage curves, and by combining the measurements with 2D numerical simulations (e.g. a combination of SUPREM and PISCES), the interface state density profiles along the channel length near the source and drain can also be obtained.
Topology-Transparent Zone (2020)

This document presents a topology-transparent zone in an area. A zone
is a block/piece of an area, which comprises a group of routers and a
number of circuits connecting them. It is abstracted as a virtual
entity such as a single pseudo node or zone edges mess. Any router
outside of the zone is not aware of the zone. The information about
the circuits and routers inside the zone is not distributed to any
router outside of the zone.
A conjecture concerning optimality of the Karhunen-Loeve basis in\n nonlinear reconstruction (2011)

We present a conjecture regarding the expectation of the maxima of $L^2$\nnorms of sub-vectors of a Gaussian vector; this has application to nonlinear\nreconstruction.\n