gebhart/patrepeval huggingface dataset:
Direct Assay of Enzymes in Heme Biosynthesis for the Detection of Porphyrias by Tandem Mass Spectrometry. Uroporphyrinogen Decarboxylase and Coproporphyrinogen III Oxidase (2008)

We report new assays of enzymes uroporphyrinogen decarboxylase (UROD) and coproporphyrinogen III oxidase (CPO) in the heme biosynthetic pathway. The assays were developed for use in clinical diagnostics of inherited disorders porphyria cutanea tarda and hereditary coproporphyria, respectively. Electrospray ionization tandem mass spectrometry is used to monitor the decarboxylation of pentaporphyrinogen I or uroporphyrinogen III catalyzed by UROD and to determine the enzyme activity in human erythrocytes by measuring the production of coproporphyrinogen I or III. The Km value for pentaporphyrinogen I was measured as 0.17 +/- 0.03 microM. A mass spectrometric assay was also developed for the two-step decarboxylative oxidation of coproporphyrinogen III to protoporphyrinogen IX catalyzed by CPO in mitochondria from human lymphocytes (Km = 0.066 +/- 0.009 microM). The assays show good reproducibility, use simple workup by liquid-liquid extraction of enzymatic products, and employ commercially available substrates and internal standards.
Anisotropic Modeling of Bone Tissue with Composite Structure of HAp-Collagen (2004)

Bone tissue is a composite material composed of hydroxyapatite (HAp) and collagen. As HAp particles in bone tissue are crystal structure, X-ray diffraction method can be used to measure the lattice strain of HAp. To estimate a stress in bone tissue from the lattice strain measured, it has to be found that a relationship between the lattice strain and macroscopic strain of bone tissue. This work presents a method to constitute an anisotropic bone model composed of HAp and collagen matrix. To make an optimal bone model, anisotropic elastic modulus was evaluated by comparing with actual elastic modulus of cortical bone in a shaft of bovine femur. The relationship between the strain of HAp phase and macroscopic strain of bone tissue was obtained from the optimal FEM model.
Is Melatonin Treatment Effective for Tardive Dyskinesia? (2000)

Supraphysiologic doses of melatonin do not positively affect tardive dyskinesia. Considering that melatonin is a safe drug, further studies are needed of higher doses and in patients with shorter disease duration before its use in the treatment of tardive dyskinesia is ruled out.
Wide Area Augmentation System (1996)

I N time, the Global Positioning System (GPS) will be used for a wide variety of aircraft operations. However, aircraft use of any satellite-based navigation system raises significant concern with respect to integrity (hazardous but undetected faults), reliability (continuity of service), time availability, and accuracy. After all, a single satellite malfunction would affect users over a huge geographic area. A navigation system with integrity warns its users if position errors may be greater than a prespecified alarm limit. Clearly, radionavigation systems used by aviators must have integrity, and the integrity requirement depends on whether the system is the primary navigation aid or supplements another system. The wide area augmentation system (WAAS) is a safety-critical system consisting of a signal-in-space and a ground network to support enroute through precision approach air navigation. It is designed to augment GPS so that it can be used as the primary navigation sensor. The WAAS augments GPS with the following three services: a ranging function, which improves availability and reliability; differential GPS corrections, which improve accuracy; and integrity monitoring, which improves safety. The WAAS is shown in Fig. 1. As shown, the WAAS broadcasts GPS integrity and correction data to GPS users and also provides a ranging signal that augments GPS. In the near future, the WAAS signal will be broadcast to users from geostationary satellites. Inmarsat-3 satellites will be the first to carry the WAAS navigation payload, and they are scheduled to be launched in 1996.
NIKA2: a mm camera for cluster cosmology (2017)

Galaxy clusters constitute a major cosmological probe. However, Planck 2015 results has shown a weak tension between CMB-derived and cluster-derived cosmological parameters. This tension might be due to poor knowledge of the cluster mass and observable relationship. As for now, arcmin resolution Sunyaev-Zeldovich (SZ) observations (e.g. SPT, ACT and Planck) only allowed detailed studies of the intra cluster medium for low redshift clusters ($z<0.2$). For high redshift clusters ( z>0.5) high resolution and high sensitivity SZ observations are needed. With both a wide field of view (6.5 arcmin) and a high angular resolution (17.7 and 11.2 arcsec at 150 and 260 GHz), the NIKA2 camera installed at the IRAM 30-m telescope (Pico Veleta, Spain) is particularly well adapted for these observations. The NIKA2 SZ observation program will map a large sample of clusters (50) at redshifts between 0.5 and 0.9. As a pilot study for NIKA2, several clusters of galaxies have been observed with the pathfinder, NIKA, at the IRAM 30-m telescope to cover the various configurations and observation conditions expected for NIKA2.
Power management solutions for computer systems and datacenters (2008)

The growing power and cooling requirements of high-density computing systems pose significant challenges for the design and operation of computers and their facilities. The rising operating expenses for datacenters demand the implementation of energy-efficient technologies and the best power management solutions. This tutorial addresses power management and cooling solutions from the individual computer system level to the datacenter. The audience will learn about the fundamental nature of the problems, approaches to developing solutions, available commercial solutions, and current research directions.
Cross-Metathesis Assisted by Microwave Irradiation (2005)

Microwave irradiation effectively accelerates cross-coupling metathesis reactions between deactivated olefins. Reactions have been carried out with the phosphine-free Hoveyda-Grubbs catalyst and the "second generation Grubbs' catalyst." While there have been reports that a "microwave effect" is observed in various transformations, the accelerations we observe are due to the efficient and rapid heating and increased pressure in the microwave apparatus.
Clinical Features and ATTCT Repeat Expansion in Spinocerebellar Ataxia Type 10 (2002)

Seizure is an integral part of the spinocerebellar ataxia type 10 phenotype, with documented morbidity and mortality. Family-dependent factors may alter the frequency of the seizure phenotype and the pattern of intergenerational repeat size changes, making the genotype-phenotype correlation complex.
ASTEROIDS: Exploring Swarms of Mini-Telepresence Robots for Physical Skill Demonstration (2022)

Online synchronous tutoring allows for immediate engagement between instructors and audiences over distance. However, tutoring physical skills remains challenging because current telepresence approaches may not allow for adequate spatial awareness, viewpoint control of the demonstration activities scattered across an entire work area, and the instructor’s sufficient awareness of the audience. We present Asteroids, a novel approach for tangible robotic telepresence, to enable workbench-scale physical embodiments of remote people and tangible interactions by the instructor. With Asteroids, the audience can actively control a swarm of mini-telepresence robots, change camera positions, and switch to other robots’ viewpoints. Demonstrators can perceive the audiences’ physical presence while using tangible manipulations to control the audience’s viewpoints and presentation flow. We conducted an exploratory evaluation for Asteroids with 12 remote participants in a model-making tutorial scenario with an architectural expert demonstrator. Results suggest our unique features benefitted participants’ engagement, sense of presence, and understanding.
Electrochemical behavior of the vitamin B12a/vitamin B12r couple on mercury and platinum electrodes (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemical behavior of the vitamin B12a/vitamin B12r couple on mercury and platinum electrodesC. L. Schmidt, C. F. Kolpin, and H. S. SwoffordCite this: Anal. Chem. 1981, 53, 1, 41–47Publication Date (Print):January 1, 1981Publication History Published online1 May 2002Published inissue 1 January 1981https://pubs.acs.org/doi/10.1021/ac00224a012https://doi.org/10.1021/ac00224a012research-articleACS PublicationsRequest reuse permissionsArticle Views71Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Paper Session II-A - Polyimide Foam Insulation Materials for Aerospace Vehicles and Spaceport Applications (2004)

Advancements in high temperature materials by NASA have led to the development of polyimide foam systems with very attractive properties. The properties generated demonstrate the suitability of these materials for use as insulation for cryogenic fuel tanks on next generation vehicles, commercial and military ships, and potentially commercial aircraft. The significance of structural polyimide foams can be realized with a reduction in the overall weight of a launch vehicle. Due to a polyimide' s high operating temperature ("'"' 260°C) structural polyimide foams can potentially reduce the amount of Thermal Protection System (TPS) and TPS integration structure that is required on launch vehicles. The lowtemperature elasticity of other polyimide foams is an enabling feature for many new cryogenic applications. These high performance materials also have properties that fulfill the demanding upcoming needs in ground support equipment for a Spaceport Technology Center. In a research study performed by Kennedy Space Center (KSC) and Langley Research Center (LaRC), polyimide foams were investigated for their physical, mechanical, thermal, and flammability properties. Variations in chemical structure, cell surface area, cell content and density on the resultant physical properties of the foams were studied. Data generated from this research revealed vital information involving foam technology and the interplay of factors such as foam density, open-closed cell content, surface area, and cell structure on the overall performance of the material. By controlling these parameters, new thermal insulation systems based on polyimide foam materials can be designed to meet demanding applications for spaceports and space vehicles.
No More Than 6ft Apart: Robust K-Means via Radius Upper Bounds (2022)

Centroid based clustering methods such as k-means, k-medoids and k-centers are heavily applied as a go-to tool in exploratory data analysis. In many cases, those methods are used to obtain representative centroids of the data manifold for visualization or summarization of a dataset. Real world datasets often contain inherent abnormalities, e.g., repeated samples and sampling bias, that manifest imbalanced clustering. We propose to remedy such a scenario by introducing a maximal radius constraint r on the clusters formed by the centroids, i.e., samples from the same cluster should not be more than 2r apart in terms of ℓ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> distance. We achieve this constraint by solving a semi-definite program, followed by a linear assignment problem with quadratic constraints. Through qualitative results, we show that our proposed method is robust towards dataset imbalances and sampling artifacts. To the best of our knowledge, ours is the first constrained k-means clustering method with hard radius constraints. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup>
Ultra-fast all optical signal processing based on PPLN waveguides (2010)

Ultra-fast all optical signal processing based on PPLN waveguides is demonstrated. Add/drop multiplexing, logic operations, optical regeneration, data exchange and grooming are demonstrated for OOK data signals up to 640 Gb/s.
Glenosphere Disengagement: A Potentially Serious Default in Reverse Shoulder Surgery (2008)

Erratum to: Clin Orthop Relat Res (2008) 466:892-898 DOI 10.1007/s11999-007-0090-6 We discovered a numerical mistake in the total number and type of prostheses and subsequently wrongfully concluded a partial disengagement occurred in 45.4% of the AequalisTM prostheses when in fact the rate was much lower. We wish to correct our report. We hope an adjustment can be made and we apologize for any inconvenience we have caused. We reviewed 396 patients with 407 reverse shoulder arthroplasties (342 Delta IIITM prostheses [DePuy International Ltd, Leeds, UK], 65 AequalisTM prostheses [Tornier, Grenoble, France] from the French multicenter study (Omarthrose excentrée, Société Française de Chirurgie Orthopédique et Traumatologique-SOFCOT, Paris, France, 2006), and 30 patients with 30 Delta IIITM from the University Hospital Pellenberg (Pellenberg, Belgium). All prostheses were implanted after 1995. The total number of reviewed prostheses was thus 437 (372 Delta IIITM and 65 AequalisTM). Disengagement of the glenosphere occurred in 14 of 437 shoulders (3.2%). In 11 patients, the disengagement was partial (clear step-off between the baseplate and the glenosphere) and was not associated with a poor functional outcome with this short-term followup. Partial disengagement was seen in five of 65 AequalisTM prostheses (7.7%) (not five of 11 or 45.4% as noted in the paper) and six of 372 Delta IIITM prostheses (1.7%). In three patients, the disengagement led to fracture of the central screw, leading to complete disengagement of the glenosphere from the baseplate, necessitating revision in two; the third refused revision. The three total disengagements with central screw breakage all occurred in Delta IIITM prostheses. We believe differences in the type of locking screws may explain the differences observed between the two types of reverse prostheses.
ChemInform Abstract: Efficient Synthesis of exo‐1‐Azabicyclo(2.2.1)heptan‐3‐ol. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
General method for the synthesis of 3- and 3,4-substituted furans. Simple syntheses of perillene and dendrolasin (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeneral method for the synthesis of 3- and 3,4-substituted furans. Simple syntheses of perillene and dendrolasinMichael E. Garst and Thomas A. SpencerCite this: J. Am. Chem. Soc. 1973, 95, 1, 250–252Publication Date (Print):January 1, 1973Publication History Published online1 May 2002Published inissue 1 January 1973https://pubs.acs.org/doi/10.1021/ja00782a051https://doi.org/10.1021/ja00782a051research-articleACS PublicationsRequest reuse permissionsArticle Views788Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Tables 1 - 2, Figure 1 from A Dose-Escalation Study of SAR3419, an Anti-CD19 Antibody Maytansinoid Conjugate, Administered by Intravenous Infusion Once Weekly in Patients with Relapsed/Refractory B-cell Non-Hodgkin Lymphoma (2023)

&lt;p&gt;PDF file - 224K, Supplemental table 1: Mean (CV%) PK parameters of SAR3419 at 55 mg/m2 obtained after first and last administration. Supplemental figure 1: SAR3419 Ctrough observed during repeated intravenous infusion of SAR3419 using weekly or optimized schedules. Supplemental table 2: relationship between CD19 expression, proliferation (KI67), mitosis (pHH3) and p53 status with observed observed responses at the MTD during the optimized schedule.&lt;/p&gt;
Cardiovascular Substructure Dose and Cardiac Events following Proton- and Photon-Based Chemoradiotherapy for Non-Small Cell Lung Cancer (2023)

Proton therapy may have a significant effect on decreasing dose to individual cardiovascular substructures compared with photon therapy. There was no significant difference in heart dose or dose to any cardiovascular substructure between patients who did and did not experience post-treatment cardiac events. Further research should be done to assess the association between cardiovascular substructure dose and post-treatment cardiac events.
Correlation between connexin 32 gene mutations and clinical phenotype in X-linked dominant Charcot-Marie-tooth neuropathy (1996)

We studied the relationship between the genotype and clinical phenotype in 27 families with dominant X-linked Charcot-Marie-Tooth (CMTX1) neuropathy. Twenty-two families showed mutations in the coding region of the connexin32 (cx32) gene. The mutations include four nonsense mutations, eight missense mutations, two medium size deletions, and one insertion. Most missense mutations showed a mild clinical phenotype (five out of eight), whereas all nonsense mutations, the larger of the two deletions, and the insertion that produced frameshifts showed severe phenotypes. Five CMTX1 families with mild clinical phenotype showed no point mutations of the cx32 gene coding region. Three of these families showed positive genetic linkage with the markers of the Xq13.1 region. The genetic linkage of the remaining two families could not be evaluated because of their small size.
Performance comparison between electrical and optical backplanes (2013)

Summary form only given. The exponential growing of the requested bandwidth capacity for high performance computing systems requires the development of novel backplane solutions within the rack as well as for the rack-to-rack fabric interconnections [1]. The solutions currently used are based on copper interconnections via backplane, driven by a suitable transceivers subsystem. The evolution of the transmitting and receiving interfaces, of the connectors, and of the printed board (PB) technology has allowed to increase the single interface bandwidth, limiting the power consumption and increasing the integration. While the consumption measured in W per Gb/s has had an exponential decrease, the consumption of the interface including serializer/deserializer, clock data recovery, pre-emphasis and equalization is growing. Furthermore, the complexity and density increasing is supported by evolving silicon technology able to manage more W/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The realization of the transmission lines in PB even if based on the most sophisticated materials available on the market, shows very significant losses at very high working frequency. Also connectors, even if now very optimized, contribute to increase loss and crosstalk. We believe that the electrical backplane is close to reach its limitation. Hence, alternative solutions have to be explored. Due to the fact that optical technologies [2-4] are able to provide higher capacity over longer distances than electrical transmission systems, a natural answer to the limitations shown by the Cu-based interconnections is to exploit fiber optical backplane [5].In this paper we simulate by means of HyperLynx® tool the performance of electrical backplane configurations based on copper interconnects, considering the best dielectric materials available on the market and their related roughness, the best Cu stripline width and dielectric thickness (in Fig. 1, on the left the parameters used in the simulations; on the right a result of the simulations). Electrical backplane remains limited by line loss: high frequency is possible, paying in terms of complexity and costs of interfaces. A possible solution based on fiber optics backplane is carried out in order to demonstrate its capabilities, in terms of capacity, power budget and consumption. We consider high-performance 25-Gbps VCSEL source [6] at 850 nm as optical source, together with a commercial photodiode. Unlike the electrical backplane, the optical solution is not limited in transmitted frequency by the backplane implementation, but only by the chosen bandwidth of the exploited TX/RX devices, saving more than half of consumption power.
Narrative Design Patterns for Data-Driven Storytelling (2018)

This chapter presents a set of narrative design patterns data-driven storytellers but not exclusively, on data visualization. The specific intents and possible combinations of patterns should be defined by the narrator. Patterns can overlap, they can be fuzzy, and in some cases, they may only be applicable to a single type of story. Patterns for argumentation serve the intent of persuading and convincing audiences. Repetition can also help argumentation, as it can increase a message's importance and memorability, and can help tie together different arguments about a given data set. Patterns for flow are devices that help structure the sequencing of messages and arguments. They are essential to every story, as they set the order, rhythm, and pace, and help buildup the climax and resolution. Emotion and empathy are critical in storytelling. In fictional stories, empathy and emotions are evoked through realistic characters and situations; technology has provided us with immersive experiences through sound and stereovision.