gebhart/patrepeval huggingface dataset:
Glucocorticoid-induced Lymphocytolysis Is Not Mediated by an Induced Endonuclease (1989)

The mechanism of glucocorticoid-induced internucleosomal DNA cleavage and cytolysis of lymphatic cells is not known. Recent data (Compton, M.M., and Cidlowski, J.A. (1987) J. Biol. Chem. 262, 8288-8292) suggested that in vivo treatment of rat thymocytes with glucocorticoids induces a nucleolytic "lysis gene" product(s) responsible for lymphocytolysis. In this paper, the possibility that lymphocytolysis may result from glucocorticoid-induced nuclease(s) was examined. Using the rat thymocytes as a model system, we have shown by electrophoretic, enzymatic, and amino acid sequence analysis that the putative glucocorticoid-induced nucleases identified recently by Compton and Cidlowski are in fact H1, H1(0), and core histones, and their gross appearance is not the result of new histone protein synthesis, but a result of the release of histone-containing nucleosomes during chromatin breakdown. Evidence presented here shows that the putative induced nuclease activity is an artifact of the assay system employed. Because our data do not support induction of a glucocorticoid-induced nuclease(s), we examined the possibility that DNA cleavage might be induced by activation of a constitutive endogenous endonuclease. We have shown that it is possible to produce characteristic internucleosomal DNA cleavage of rat thymocytes, merely by incubating intact nuclei from untreated adrenalectomized rat thymocytes with Ca2+ and Mg2+ for a short period of time. However, in glucocorticoid-sensitive human CEM-C7 lymphocytes activation of internucleosomal DNA cleavage was independent of calcium uptake. We conclude that glucocorticoid induction of internucleosomal DNA fragmentation does not necessarily require expression of a new nuclease(s), but is the result of the activation of a constitutive endogenous endonuclease(s). Also, our data suggest that the mechanism which controls activation of internucleosomal DNA cleavage in rat thymocytes differs from that which operates in CEM-C7 lymphocytes.
Improved magneto-optic trapping in a vapor cell (1992)

We have captured 3.6 x 10(10) cesium atoms in a magneto-optic trap loaded from a vapor cell. The 300-fold increase in the number of trapped atoms compared with that of previous research was accomplished by using larger laser intensities and 4-cm-diameter laser beams. The loading time constant was as short as 0.2 s.
A Blueprint to Advance Colorectal Cancer Immunotherapies (2017)

Immunotherapy is rapidly becoming a standard of care for many cancers. However, colorectal cancer had been generally resistant to immunotherapy, despite features in common with sensitive tumors. Observations of substantial clinical activity for checkpoint blockade in colorectal cancers with defective mismatch repair (microsatellite instability-high tumors) have reignited interest in the search for immunotherapies that could be extended to the larger microsatellite stable (MSS) population. The Cancer Research Institute and Fight Colorectal Cancer convened a group of scientists, clinicians, advocates, and industry experts in colorectal cancer and immunotherapy to compile ongoing research efforts, identify gaps in translational and clinical research, and provide a blueprint to advance immunotherapy. We identified lack of a T-cell inflamed phenotype (due to inadequate T-cell infiltration, inadequate T-cell activation, or T-cell suppression) as a broad potential explanation for failure of checkpoint blockade in MSS. The specific cellular and molecular underpinnings for these various mechanisms are unclear. Whether biomarkers with prognostic value, such as the immunoscores and IFN signatures, would also predict benefit for immunotherapies in MSS colon cancer is unknown, but if so, these and other biomarkers for measuring the potential for an immune response in patients with colorectal cancer will need to be incorporated into clinical guidelines. We have proposed a framework for research to identify immunologic factors that may be modulated to improve immunotherapy for colorectal cancer patients, with the goal that the biomarkers and treatment strategies identified will become part of the routine management of colorectal cancer. <i>Cancer Immunol Res; 5(11); 942-9. ©2017 AACR</i>.
ChemInform Abstract: KOORDINATIONSCHEMIE VON BASISCHEN PHOSPHORDONATOREN 1. MITT. KOMPLEXE VON KOBALT UND NICKEL MIT TRIMORPHOLINOPHOSPHIN (1970)

Abstract Die gegen Feuchtigkeit empfindlichen Komplexe (II) wurden aus dem Phosphin (I) und den entsprechenden Metallsalzen in Alkohol dargestellt und durch Konduktometrie, Elektronenspektren und Messungen der magnetischen Suszeptibilität charakterisiert.
Single-Event Burnout of SiC Junction Barrier Schottky Diode High-Voltage Power Devices (2017)

Ion-induced degradation and catastrophic failures in high-voltage SiC junction barrier Schottky power diodes are investigated. The experimental results agree with earlier data showing discrete jumps in leakage current for individual ions and show that the boundary between leakage current degradation and a single-event-burnout-like effect is a strong function of linear energy transfer and reverse bias. TCAD simulations show high localized electric fields under the Schottky junction, and high temperatures generated directly under the Schottky contact, consistent with the hypothesis that the ion energy causes eutectic-like intermixture at the metal-semiconductor interface or localized melting of the silicon carbide lattice.
Forecast techniques for predicting increase or decrease of attacks using Bayesian inference (2005)

The analysis techniques of intrusion detection system (IDS) events are actively researched, since it is important to understand attack trends and devise countermeasures against incidents. To aim at a quick response in security operation, it is necessary to forecast a fluctuation of attacks. However, there is no approach for predicting the fluctuation of attacks, since the fluctuation of attacks seems to be random. In this paper, we propose forecast techniques for predicting increase or decrease of the attacks by using the Bayesian inference for calculating the conditional probability based on past-observed event counts. We consider two algorithms by focusing on an attack cycle and a fluctuation range of the event counts. We implement a forecasting system and evaluate it with real IDS events. As a result, our proposed technique can forecast increase or decrease of the event counts, and be effective to various types of attacks.
A Model of Toxic Neuropathy inDrosophilaReveals a Role for MORN4 in Promoting Axonal Degeneration (2012)

Axonal degeneration is a molecular self-destruction cascade initiated following traumatic, toxic, and metabolic insults. Its mechanism underlies a number of disorders including hereditary and diabetic neuropathies and the neurotoxic side effects of chemotherapy drugs. Molecules that promote axonal degeneration could represent potential targets for therapy. To identify such molecules, we designed a screening platform based on intoxication of Drosophila larvae with paclitaxel (taxol), a chemotherapeutic agent that causes neuropathy in cancer patients. In Drosophila, taxol treatment causes swelling, fragmentation, and loss of axons in larval peripheral nerves. This axonal loss is not due to apoptosis of neurons. Taxol-induced axonal degeneration in Drosophila shares molecular execution mechanisms with vertebrates, including inhibition by both NMNAT (nicotinamide mononucleotide adenylyltransferase) expression and loss of wallenda/DLK (dual leucine zipper kinase). In a pilot RNAi-based screen we found that knockdown of retinophilin (rtp), which encodes a MORN (membrane occupation and recognition nexus) repeat-containing protein, protects axons from degeneration in the presence of taxol. Loss-of-function mutants of rtp replicate this axonal protection. Knockdown of rtp also delays axonal degeneration in severed olfactory axons. We demonstrate that the mouse ortholog of rtp, MORN4, promotes axonal degeneration in mouse sensory axons following axotomy, illustrating conservation of function. Hence, this new model can identify evolutionarily conserved genes that promote axonal degeneration, and so could identify candidate therapeutic targets for a wide-range of axonopathies.
ChemInform Abstract: Biosynthetic Studies of Marine Lipids. Part 39. 19‐Norsterols: The Course of C‐19 Methyl Elimination. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Wavetable synthesis strategies for mobile devices (2005)

Table look-up (or fixed-wavetable) music synthesis has recently received new interest in the context of mobile applications such as personalized ring tones and pager notification signals: the market for consumers purchasing polyphonic ring tones exceeded US $4 billion worldwide in 2004. Table look-up (or fixed-wavetable) synthesis methods have been widely used for many years in music synthesizers. The limited amount of storage and transmission bandwidth available in such mobile devices makes the use of compressed synthesizer data desirable. The important considerations for implementing a wavetable music synthesizer in a small portable device are described. In particular, an efficient compression/decompression method for the synthesizer data is used in order to reduce the size of the synthesizer data bank with good fidelity while still maintaining the loop continuity constraints necessary for looped wavetable synthesis.
Multimodal location estimation (2010)

In this article we define a multimedia content analysis problem, which we call multimodal location estimation: Given a video/image/audio file, the task is to determine where it was recorded. A single indication, such as a unique landmark, might already pinpoint a location precisely. In most cases, however, a combination of evidence from the visual and the acoustic domain will only narrow down the set of possible answers. Therefore, approaches to tackle this task should be inherently multimedia. While the task is hard, in fact sometimes unsolvable, training data can be leveraged from the Internet in large amounts. Moreover, even partially successful automatic estimation of location opens up new possibilities in video content matching, archiving, and organization. It could revolutionize law enforcement and computer-aided intelligence agency work, especially since both semi-automatic and fully automatic approaches would be possible. In this article, we describe our idea of growing multimodal location estimation as a research field in the multimedia community. Based on examples and scenarios, we propose a multimedia approach to leverage cues from the visual and the acoustic portions of a video as well as from given metadata. We also describe experiments to estimate the amount of available training data that could potentially be used as publicly available infrastructure for research in this field. Finally, we present an initial set of results based on acoustic and visual cues and discuss the massive challenges involved and some possible paths to solutions.
Superhydrophobic, High Surface Area, 3-D SiO2 Nanostructures through Siloxane-Based Surface Functionalization (2004)

ADVERTISEMENT RETURN TO ISSUEPREVNoteSuperhydrophobic, High Surface Area, 3-D SiO2 Nanostructures through Siloxane-Based Surface FunctionalizationShufen Tsoi, Enrico Fok, Jeremy C. Sit, and Jonathan G. C. VeinotView Author Information Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta, T6G 2V4 Canada, and Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2 Canada Cite this: Langmuir 2004, 20, 24, 10771–10774Publication Date (Web):October 26, 2004Publication History Received12 July 2004Revised9 September 2004Published online26 October 2004Published inissue 1 November 2004https://pubs.acs.org/doi/10.1021/la0482507https://doi.org/10.1021/la0482507brief-reportACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views1298Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Functionalization,Hydrophobicity,Nanostructures,Surface chemistry,Thin films Get e-Alerts
Diffusion-Weighted Imaging in Cancer: Physical Foundations and Applications of Restriction Spectrum Imaging (2014)

Diffusion-weighted imaging (DWI) has been at the forefront of cancer imaging since the early 2000s. Before its application in clinical oncology, this powerful technique had already achieved widespread recognition due to its utility in the diagnosis of cerebral infarction. Following this initial success, the ability of DWI to detect inherent tissue contrast began to be exploited in the field of oncology. Although the initial oncologic applications for tumor detection and characterization, assessing treatment response, and predicting survival were primarily in the field of neurooncology, the scope of DWI has since broadened to include oncologic imaging of the prostate gland, breast, and liver. Despite its growing success and application, misconceptions about the underlying physical basis of the DWI signal exist among researchers and clinicians alike. In this review, we provide a detailed explanation of the biophysical basis of diffusion contrast, emphasizing the difference between hindered and restricted diffusion, and elucidating how diffusion parameters in tissue are derived from the measurements via the diffusion model. We describe one advanced DWI modeling technique, called restriction spectrum imaging (RSI). This technique offers a more direct in vivo measure of tumor cells, due to its ability to distinguish separable pools of water within tissue based on their intrinsic diffusion characteristics. Using RSI as an example, we then highlight the ability of advanced DWI techniques to address key clinical challenges in neurooncology, including improved tumor conspicuity, distinguishing actual response to therapy from pseudoresponse, and delineation of white matter tracts in regions of peritumoral edema. We also discuss how RSI, combined with new methods for correction of spatial distortions inherent in diffusion MRI scans, may enable more precise spatial targeting of lesions, with implications for radiation oncology and surgical planning. See all articles in this Cancer Research section, "Physics in Cancer Research."
High-precision analog EEPROM with real-time write monitoring (2002)

We have developed a non-volatile high-precision analog EEPROM comprising two transistors per cell. In this newly developed memory, real-time write monitoring (RTM) is employed during cell programming to achieve automatic write termination without conventional write-verify cycles. Highly accurate data writing has been realized using a new self-calibrated offset cancellation scheme involving the double auto-zeroing of a chopper comparator. Fundamental circuit operation is verified experimentally on fabricated test circuits. Without the need for time-consuming write-verify cycles, the new analog EEPROM is suitable for use in analog signal processing applications with real-time information processing requirements.
Supplementary video 2 from Three-Dimensional Breast Cancer Models Mimic Hallmarks of Size-Induced Tumor Progression (2023)

&lt;p&gt;MCF7 600 μm microtumor crawling out of the microwell&lt;/p&gt;
ChemInform Abstract: Stereocontrolled Elaboration of Natural (‐)‐Polycavernoside A, a Powerfully Toxic Metabolite of the Red Alga Polycavernosa tsudai. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Natural Rubber Waste Derived Surfactant for High Internal Phase Emulsion Templating of Poly(dicyclopentadiene) (2021)

The use of a surfactant derived from the degradation of natural rubber gloves via cross-metathesis with methyl acrylate and subsequent saponification of the ester group for the stabilization of water in dicyclopentadiene high internal phase emulsions is described. The versatility of the resulting high internal phase emulsion was demonstrated by polymerizing the continuous dicyclopentadiene phase via Ring-opening Metathesis Polymerization yielding macroporous poly(dicyclopentadiene) foams with a porosity of 82 %. The use of the ionic surfactant allows for the preparation of foams, which are resistant to absorb water. This property was hitherto not accessible with protocols involving the use of non-ionic surfactants commonly employed in emulsion templating of polymers.
Evaluation techniques of frequency-dependent I/Q imbalances in wideband quadrature mixers (2010)

As bandwidths of digital wireless communications get wider, it is essential to evaluate the I/Q imbalances among quadrature mixer ports in terms of the mismatch characteristics of the analog components in the I and Q paths and the carrier phase offset. This paper describes a technique to evaluate frequency-dependent I/Q imbalances and carrier phase offset in wideband quadrature mixers. Using an SSB stimulus, the response of a DUT with imbalances is modeled mathematically, and an identification algorithm using a unique input stimulus is constructed. The validity of this technique is confirmed using an actual WiMAX transceiver on an ATE.
A Space-Filling Visualization Technique for Multivariate Small-World Graphs (2011)

We introduce an information visualization technique, known as GreenCurve, for large multivariate sparse graphs that exhibit small-world properties. Our fractal-based design approach uses spatial cues to approximate the node connections and thus eliminates the links between the nodes in the visualization. The paper describes a robust algorithm to order the neighboring nodes of a large sparse graph by solving the Fiedler vector of its graph Laplacian, and then fold the graph nodes into a space-filling fractal curve based on the Fiedler vector. The result is a highly compact visualization that gives a succinct overview of the graph with guaranteed visibility of every graph node. GreenCurve is designed with the power grid infrastructure in mind. It is intended for use in conjunction with other visualization techniques to support electric power grid operations. The research and development of GreenCurve was conducted in collaboration with domain experts who understand the challenges and possibilities intrinsic to the power grid infrastructure. The paper reports a case study on applying GreenCurve to a power grid problem and presents a usability study to evaluate the design claims that we set forth.
Involvement of multiple receptors in the biological effects of calcitonin gene‐related peptide and amylin in rat and guinea‐pig preparations (1992)

1. The activity of rat alpha and beta calcitonin gene-related peptide (CGRP) as compared to the structurally related peptide, rat amylin, has been investigated in the guinea-pig isolated left atrium (electrically driven), in mucosa-free strips from the base of the guinea-pig urinary bladder and in the rat isolated vas deferens (pars prostatica). The antagonist activity of the C-terminal fragment of human alpha CGRP, alpha CGRP(8-37), was also investigated. 2. In the guinea-pig isolated left atrium the three peptides produced a concentration-related positive inotropic effect, amylin being about 16 and 31 times less potent than alpha or beta CGRP, respectively. Human alpha CGRP(8-37) produced a rightward displacement of the log concentration-response curve to the three agonists tested, without depression of maximal response attainable. Apparent pKB values calculated on the basis of the displacement produced by 1 microM human alpha CGRP(8-37) indicated an agonist-independent affinity of the antagonist (6.66 +/- 0.11 for alpha CGRP, 6.42 +/- 0.17 for beta CGRP and 6.95 +/- 0.11 for amylin). 3. In the guinea-pig isolated urinary bladder, alpha or beta CGRP or amylin produce a concentration-related inhibition of twitch contractions evoked by train electrical field stimulation (10 Hz frequency, 0.25 ms duration at 100 V for 0.5 s every 60 s). Amylin was about 100 times less potent than alpha or beta CGRP. Human alpha CGRP(8-37) (3 microM) did not significantly affect the inhibitory action of the three agonists tested.4. In the rat isolated vas deferens, a or PCGRP or amylin produced a concentration-related inhibition of twitch contractions evoked by electrical field stimulation (0.2 Hz frequency, 0.5 ms duration at 60 volts). Amylin was about 100 times less potent than a or PCGRP. Human aCGRP(8-37) at 3 microM did not significantly affect the inhibitory action of amylin and at 3 microM antagonized the responses to rat a and PCGRP with apparent pKB values of 5.86 +/- 0.15 and 6.11 +/- 0.13, respectively.5. These findings indicate that multiple receptors mediate the actions of peptides of the CGRP/amylin family in the preparations investigated. In the guinea-pig atrium both a and P forms of rat CGRP as well as amylin act by stimulating a single class of receptors which are sensitive to the inhibitory action of human aCGRP(8-37). In rat isolated vas deferens, at least two receptors could be present, one activated by a and PCGRP and partially sensitive to human aCGRP(8-37) and another which is sensitive to amylin but not recognised by human aCGRP(8-37). This latter type of receptor could be entirely responsible for the action of the agonists in the guinea-pig urinary bladder.
Electri-Fi Your Data: Measuring and Combining Power-Line Communications with WiFi (Technical Report 210617, EPFL) (2015)

INDY2
Diffraction limited amplification of picosecond pulses in 1170μm^2 effective area erbium fiber (2008)

Robust fundamental mode propagation and amplification of picosecond pulses at 1.56 microm wavelength is demonstrated in a core-pumped Er fiber with 1170 microm2 effective area. Record peak power exceeding 120 kW, and 67 nJ pulse energy are achieved before the onset of pulse breakup. A small increase in input pulse energy results in a temporal collapse of the pulse center to 58 fs duration, with peak powers approaching 200 kW.
Investigating risk factors for urine culture contamination in outpatient clinics: A new avenue for diagnostic stewardship (2022)

Abstract Mixed flora in urine cultures usually occur due to preanalytic contamination. In our outpatient urology clinic, we detected a high prevalence of mixed flora (46.2%), which was associated with female sex and older age. Patient education did not influence the rate of mixed flora. Future efforts should target high-risk patients.