gebhart/patrepeval huggingface dataset:
Improving prediction of radiotherapy response and optimizing target definition by using FDG-PET for lung cancer patients (2007)

Another way to improve treatment outcome is to optimize the radiotherapy itself. Until the late 1990’s, X-ray images were used to depict the radiation fields. Square radiation fields around the primary tumor and mediastinum were drawn manually. To avoid the possibility of a geographical miss, these radiation fields were large. Consequently, it was not possible to apply larger doses than 50 – 60 Gy without the risk of excessive toxicity (radiation pneumonitis and/or radiation esophagitis).
Mathematical modeling and simulation of lead acid battery (2004)

In this paper, a new systematic methodology for extracting a mathematical model of a lead acid battery is developed. The developed model is based on studying the battery electrical behaviors. Also, it includes battery dynamics such as the state of charge, the change in the battery capacity, the effect of the temperature and the change in the load current representing the battery dynamics. The developed methodology depends on online learning. The algorithm used for learning is the recursive least square (RLS). The use of learning fine-tunes the parameters of a mathematical model to emulate a real battery dynamics. Also, it enables the estimated model to cover wide band of ambiguity and nonlinearity included in the battery dynamics.
Effect of Relaying on Coverage in 3GPP LTE-Advanced (2009)

Current broadband wireless networks are characterized by large cell sizes. Yet, even in advanced networks that will be built using 3 GPP Long Term Evolution (LTE), also referred to as 3GPP LTE-Advanced, or mobile WiMAX radio interface, users on the cell edge will face relatively low signal-to-interference-plus-noise-ratio (SINR). An attractive solution for this problem is provided by multihop technologies. In this paper we consider the feasibility of Decode and Forward (DF) Relay Nodes (RNs) from 3GPP LTE-Advanced perspective. We propose a novel evaluation methodology that can be used to find a relation of RN transmission power, ratio between number of Base Stations (BSs) and RNs, and performance of the system. Evaluation of DF relays in 3GPP LTE-Advanced framework indicates a good performance gain.
Structural Differences between ππ* and nπ* Acetophenone Triplet Excited States as Revealed by Time-Resolved IR Spectroscopy (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTStructural Differences between ππ* and nπ* Acetophenone Triplet Excited States as Revealed by Time-Resolved IR SpectroscopySanjay Srivastava, Emily Yourd, and John P. ToscanoView Author Information Department of Chemistry, Johns Hopkins University 3400 North Charles Street, Baltimore, Maryland 21218 Cite this: J. Am. Chem. Soc. 1998, 120, 24, 6173–6174Publication Date (Web):June 9, 1998Publication History Received1 April 1998Published online9 June 1998Published inissue 1 June 1998https://pubs.acs.org/doi/10.1021/ja981093bhttps://doi.org/10.1021/ja981093brapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views550Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Excited states,Ketones,Phenyls,Photodissociation,Resonance structures Get e-Alerts
Outcomes and Predictors of Mortality and Stoma Formation in Surgical Management of Colonoscopic Perforations (2009)

Colonoscopic perforations were in a decreasing trend. Patients with predictors of mortality should not be treated conservatively. Other options of large bowel investigations should be considered in high-risk patients when the potential diagnostic yield is low.
Mycobacterium tuberculosis components expressed during chronic infection of the lung contribute to long-term control of pulmonary tuberculosis in mice (2016)

Tuberculosis (TB) remains a major cause of mortality and morbidity worldwide, yet current control strategies, including the existing BCG vaccine, have had little impact on disease control. The tubercle bacillus modifies protein expression to adapt to chronic infection of the host, and this can potentially be exploited to develop novel therapeutics. We identified the gene encoding the first step of the <i>Mycobacterium tuberculosis</i> sulphur assimilation pathway, <i>cysD,</i> as highly induced during chronic infection in the mouse lung, suggesting therapies based on CysD could be used to target infection. Vaccination with the composite vaccine CysVac2, a fusion of CysD and the immunogenic Ag85B of <i>M. tuberculosis,</i> resulted in the generation of multifunctional CD4<sup>+</sup> T cells (interferon (IFN)-γ<sup>+</sup>TNF<sup>+</sup>IL-2<sup>+</sup>IL-17<sup>+</sup>) in the lung both pre- and post-aerosol challenge with <i>M. tuberculosis</i>. CysVac2 conferred significant protection against pulmonary <i>M. tuberculosis</i> challenge and was particularly effective at controlling late-stage infection, a property not shared by BCG. CysVac2 delivered as a booster following BCG vaccination afforded greater protection against <i>M. tuberculosis</i> challenge than BCG alone. The antigenic components of CysVac2 were conserved amongst <i>M. tuberculosis</i> strains, and protective efficacy afforded by CysVac2 was observed across varying murine MHC haplotypes. Strikingly, administration of CysVac2 to mice previously infected with <i>M. tuberculosis</i> reduced bacterial load and immunopathology in the lung compared with BCG-vaccinated mice. These results indicate that CysVac2 warrants further investigation to assess its potential to control pulmonary TB in humans.
Spatial Consistency Validation on Massive SIMO Covariance Matrices in the Geometry-Based Stochastic Channel Model QuaDRiGa. (2020)

In the fifth generation (5G) of cellular networks, massive multiple-input multiple-output (MIMO) has surged as a key technique. The time-invariant feature of the channels in a massive MIMO system is modelled using second-order-statistics known as covariance matrices. The spatial consistency of these covariance matrices, e.g. close to each other positioned mobile users receive similar multi-path components, is essential for the multiple-user performance evaluation. Therefore, spatial consistency is a must-have for 5G channel models. In this work, we provide a thorough validation of the spatial consistency feature in the open source geometry-based stochastic channel model software QuaDRiGa by comparing it with measurements. We validate the spatial consistency in terms of spatial correlation of massive single-input multiple-output (SIMO) covariance matrices in four different settings of base station (BS)-user locations.
Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers (2019)

Self-assembly of proteins to β-sheet rich amyloid fibrils is commonly observed in various neurodegenerative diseases. However, amyloid also occurs in the extracellular matrix of bacterial biofilm, which protects bacteria from environmental stress and antibiotics. Many <i>Pseudomonas</i> strains produce functional amyloid where the main component is the highly fibrillation-prone protein FapC. FapC fibrillation may be inhibited by small molecules such as plant polyphenols, which are already known to inhibit formation of pathogenic amyloid, but the mechanism and biological impact of inhibition is unclear. Here, we elucidate how polyphenols modify the self-assembly of functional amyloid, with particular focus on epigallocatechin gallate (EGCG), penta-<i>O</i>-galloyl-β-d-glucose (PGG), baicalein, oleuropein, and procyanidin B2. We find EGCG and PGG to be the best inhibitors. These compounds inhibit amyloid formation by redirecting the aggregation of FapC monomers into oligomeric species, which according to small-angle X-ray scattering (SAXS) measurements organize into core-shell complexes of short axis diameters 25-26 nm consisting of ~7 monomers. Using peptide arrays, we identify EGCG-binding sites in FapC's linker regions, C and N-terminal parts, and high amyloidogenic sequences located in the R2 and R3 repeats. We correlate our biophysical observations to biological impact by demonstrating that the extent of amyloid inhibition by the different inhibitors correlated with their ability to reduce biofilm, highlighting the potential of anti-amyloid polyphenols as therapeutic agents against biofilm infections.
ChemInform Abstract: SILICON BY SODIUM REDUCTION OF SILICON TETRAFLUORIDE (1981)

Abstract Hochreines pulverförmiges Si läßt sich gemäß Reaktion Aherstellen.
Supplementary Figure S2 from Tumor-Associated Hyaluronan Limits Efficacy of Monoclonal Antibody Therapy (2023)

&lt;p&gt;HAS2 overexpression does not alter specific cell surface protein expression.&lt;/p&gt;
The Multicast Address-Set Claim (MASC) Protocol (2000)

This document describes the Multicast Address-Set Claim (MASC) protocol which can be used for inter-domain multicast address set allocation.MASC is used by a node (typically a router) to claim and allocate one or more address prefixes to that node's domain.While a domain does not necessarily need to allocate an address set for hosts in that domain to be able to allocate group addresses, allocating an address set to the domain does ensure that inter-domain groupspecific distribution trees will be locally-rooted, and that traffic will be sent outside the domain only when and where external receivers exist.
Advanced setup for thermal cycling of power modules following definable junction temperature profiles (2010)

In this paper a setup for performing power cycling tests of IGBT modules for the purpose of reliability analysis is presented. The main purpose of the setup is to provide experimental data for the parameterization and verification of a newly developed physical model of solder deformation leading to the failure of power electronic devices. The design procedure, including considerations of reliability, measurement, and cooling, for a 5 kW flexible power cycling system is presented. Experimental results of a sub-1 kW prototype setup are shown, demonstrating the ability of the system to force the junction temperature of the device under test to follow an arbitrary temperature profile.
Cultural soundscape of the Grant-Kohrs Ranch national historic site. (2010)

It is often noted that although many parks and historic sites look as they did a century ago, very few sound as they once did. Management principles of U.S. National Parks and Historic Sites include the need to “preserve soundscape resources and values of the parks to the greatest extent possible to protect opportunities for appropriate transmission of cultural and historic sounds that are fundamental components of the purposes and values for which the parks were established.” Therefore, a critical part of soundscape management is to determine the existing ambient soundscape to detect trends and changes. An ongoing project at Grant-Kohrs Ranch National Historic Site, located just north of Deer Lodge, Montana, involves a year-long continuous audio recording and soundscape characterization. The recording status and example soundscape excerpts are presented and discussed.
Surfactant disaturated phosphatidylcholine kinetics in infants with bronchopulmonary dysplasia measured with stable isotopes and a two-compartment model (2005)

We previously found a shorter surfactant disaturated phosphatidylcholine palmitate (DSPC-PA) half-life in infants with bronchopulmonary dysplasia (BPD) by using a single stable isotope tracer and simple formulas based on a one-exponential fit of the final portion of the enrichment decay curve. The aim of this study was to apply noncompartmental and compartmental analysis on the entire enrichment decay curve of DSPC-PA and to compare the kinetic data with our previous results. We analyzed 10 preterm newborns with BPD (gestational age 26 +/- 0.6 wk, weight 777 +/- 199 g) and 6 controls (gestational age 26 +/- 1.4 wk, weight 787 +/- 259 g). All took part in our previous study. Endotracheal 13C-labeled dipalmitoyl phosphatidylcholine was administered, and the 13C-enrichment of surfactant DSPC-PA was measured from serial tracheal aspirates by gas chromatography-mass spectrometry. Noncompartmental and compartmental models were numerically identified from the tracer-to-tracee ratio and kinetic parameters related to the accessible (pool accessible to sampling, likely to be the lung alveolar pool) and to the nonaccessible pools (pools not accessible to samplings, likely to be the intracellular storage pool) were estimated in the two study groups. Comparison was performed by Mann-Whitney test. A two-compartment model provided the most reliable assessment of DSPC-PA kinetics. In BPD vs. controls, mean +/- SE residence time of DSPC-PA in the accessible was 17.5 +/- 2.6 vs. 32.2 +/- 6.4 h (P < 0.05), whereas it was 49.7 +/- 3.5 vs. 54.4 +/- 3.9 h (NS, not significant) in the nonaccessible pool; DSPC-PA recycling was 0.26 +/- 0.05 vs. 0.43 +/- 0.04% (NS), respectively. A two-compartment model of surfactant DSPC-PA kinetics allowed a thorough assessment of DSPC-PA kinetics, including masses, synthesis, and fluxes between pools. The most important findings of this study are that in BPD infants DSPC-PA loss from the alveolar pool was higher and recycling through the intracellular pool lower than in controls.
Auger recombination-induced neutralization and stretched exponential recharging in an InAs quantum dot (2019)

We investigate the charging dynamics in epitaxially grown InAs quantum dots (QDs) under resonant excitation with and without additional low-power above-band excitation. Time-resolved resonance fluorescence from a charged exciton (trion) transition is recorded as the above-band excitation is modulated on and off. The fluorescence intensity varies as the QD changes from charged to neutral and back due to the influence of the above-band excitation. We fit the transients of the decay of the time-resolved resonance fluorescence after the above-band excitation turns off with a model that represents the neutralization process. The time dependence of the transients indicate that Auger recombination of resonantly excited trions is largely responsible for neutralization of the charged state when the above-band excitation is off. Additionally, a stretched exponential component of the transient of the fluorescence decay indicates the QD is supplied with charges via carrier migration through a stochastic collection of weakly-binding sites, resulting in sub-diffusion-like dynamics.
Supplementary methods from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma (2023)

&lt;p&gt;Supplementary methods&lt;/p&gt;
Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR−/− mice (2015)

Global disruption of the GH receptor in mice (GHR-/-) produces a large and reproducible extension in lifespan. Since lack of GH action in muscle resulting in improved glucose homeostasis is potentially a mechanism by which GHR-/- mice are long-lived, and since no information on muscle-specific GHR disruption in females is available, we generated and characterized a line of muscle-specific GHR disrupted (MuGHRKO) mice. As expected, male MuGHRKO mice had improved fasting blood glucose, insulin, c-peptide, and glucose tolerance. In contrast, female MuGHRKO mice exhibited normal glucose, insulin, and glucose tolerance. Body weight was mildly but significantly altered in opposite directions in males (decreased) and females (increased) compared to controls. Grip strength and treadmill endurance were unchanged with advanced age in both sexes, suggesting that the direct action of GH on muscle has minimal effect on age-related musculoskeletal frailty. Longevity was unchanged in both sexes at Ohio University and significantly increased for males at University of Michigan. These data suggest that removal of GHR in muscle of male MuGHRKO mice replicates some of the health benefits seen in global GHR-/- mice including improvements to glucose homeostasis and smaller body weight in males, which may explain the trends observed in lifespan.
Cardiac characterization of 16 patients with large NF1 gene deletions (2012)

The aim of this study was to characterize cardiac features of patients with neurofibromatosis 1 ( NF1 ) and large deletions of the NF1 gene region. The study participants were 16 patients with large NF1 deletions and 16 age‐ and sex‐matched NF1 patients without such deletions. All the patients were comprehensively characterized clinically and by echocardiography. Six of 16 NF1 deletion patients but none of 16 non‐deletion NF1 patients have major cardiac abnormalities (p = 0.041). Congenital heart defects ( CHDs ) include mitral insufficiency in two patients and ventricular septal defect, aortic stenosis, and aortic insufficiency in one patient each. Three deletion patients have hypertrophic cardiomyopathy. Two patients have intracardiac tumors. NF1 patients without large deletions have increased left ventricular ( LV ) diastolic posterior wall thickness (p &lt; 0.001) and increased intraventricular diastolic septal thickness (p = 0.001) compared with a healthy reference population without NF1 , suggestive of eccentric LV hypertrophy. CHDs and other cardiovascular anomalies are more frequent among patients with large NF1 deletion and may cause serious clinical complications. Eccentric LV hypertrophy may occur in NF1 patients without whole gene deletions, but the clinical significance of this finding is uncertain. All patients with clinical suspicion for NF1 should be referred to a cardiologist for evaluation and surveillance.
Supplementary Methods from The Pathognomonic FOXL2 C134W Mutation Alters DNA-Binding Specificity (2023)

&lt;p&gt;Detailed supplemental methods of cell lines and cell culture, cell cycle synchronization and inducible expression of FOXL2, quantitative mass spectrometry analysis of induced FOXL2 expression, FOXL2 ChIP-seq analysis, RNA-seq analysis, and electrophoretic mobility shift assay.&lt;/p&gt;
Supplementary Figure S4 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer (2023)

&lt;p&gt;A, miR-409-5p and miR-409-3p in exosomes from ARCaPE and ARCaPM PCa cells measured by qRT-PCR. B, miR-409-5p levels in exosomes from ARCaPM-C and ARCaPM-409-5pi PCa cells measured by qRT-PCR.&lt;/p&gt;
Distinct Roles for the α and β Subunits in the Functions of Integrin αMβ2 (2004)

Integrin alphaMbeta2 (Mac-1, CD11b/CD18) is a noncovalently linked heterodimer of alphaM and beta2 subunits on the surface of leukocytes, where it plays a pivotal role in the adhesion and migration of these cells. Using HEK293 cells expressing alphaMbeta2 or the individual constituent chains on their surface, we analyzed the contributions of the alphaM or beta2 subunits to functional responses mediated by the integrin. In cells expressing only alphaM or beta2, the individual subunits were not associated with the endogenous integrins of the cells, and other partners for the subunits were not detected by surface labeling and immunoprecipitation under a variety of conditions. The alphaM cells mediated adhesion and spreading on a series of alphaMbeta2 ligands (fibrinogen, Factor X, iC3b, ICAM-1 (intercellular adhesion molecule-1), and denatured ovalbumin) but could not support cell migration to any of these. The spreading of the alphaM cells suggested an unanticipated linkage of this subunit to the cytoskeleton. The beta2 cells supported migration and attachment but not spreading on a subset of the alphaMbeta2 ligands. The heterodimeric receptor and its individual subunits were purified from the cells by affinity chromatography and recapitulated the ligand binding properties of the corresponding cell lines. These data indicate that each subunit of alphaMbeta2 contributes distinct properties to alphaMbeta2 and that, in most but not all cases, the response of the integrin is a composite of the functions of its individual subunits.
Requirement-based design methods for adaptive communications links (2004)

High-speed communications link cores must consume low-power, feature low bit-error-rates (BER), and address many applications. We present a methodology to design adaptive link architectures, whereby the link's internal logic complexity, frequency, and supply are simultaneously adapted to application requirements. The requirement space is mapped to the design space using requirements measurement circuits and configurable logic blocks. CMOS results indicate that power savings of 60 versus the worst case are possible, while the area overhead is kept under 5.
Rethink reporting of evaluation results in AI (2023)

Aggregate metrics and lack of access to results limit understanding
Chromium(III) Complexes of Sterically Crowded Bidentante {ONR} and Tridentate {ONNR} Naphthoxy-Imine Ligands: Syntheses, Structures, and Use in Ethylene Oligomerization (2009)

New bidentate {ONR}H (R = C6F5, 2c) and tridentate {ONNR}H (R = quinolyl, 2a; 2-pyridylmethyl, 2b} naphthol-imine and phenol-imine (R = quinolyl, 2d) pro-ligands sterically encumbered by an ortho-triphenylsilyl moiety have been prepared and converted to the corresponding naphthoxy-imino (3a−c) and phenoxy-imino (3d) CrBr2{ON(N)R}(CH3CN) complexes, respectively, via reaction with (p-tolyl)CrBr2(THF)3 and subsequent recrystallization from acetonitrile. The molecular structures of 2a, 2d, 3a, and 3b have been established by single-crystal X-ray diffraction studies. Upon activation with MAO, complexes 3a, 3b, and 3d, despite the presence of coordinated acetonitrile in those precursors, lead to highly active catalysts for the oligomerization of ethylene (activities up to 23 730 kg mol−1 h−1 at 25−100 °C, 6 bar), yielding selectively linear α-olefins (89−96% vinyl-end; Mn = 600−1450 g mol−1, Mw/Mn = 1.9−2.3).
ChemInform Abstract: RK. MIT ELEKTRONTRANSFER 1. MITT. RED. VON 2,2,6,6‐TETRAMETHYL‐4‐HEPTENON‐(3) (1970)

Abstract Die polarographischen Reduktionspotentiale und Halbwertszeiten der prim. gebildeten Radikalanion‐Reduktionsprodukte von ogß‐ungesättigten Ketonen, z.B. von (I) und seinem cis‐Isomeren, werden gemessen.
Development of a monoenergetic ultraslow antiproton beam source for high-precision investigation (2012)

The ASACUSA collaboration developed an ultraslow antiproton beam source, monoenergetic ultraslow antiproton source for high-precision investigation (MUSASHI), consisting of an electromagnetic trap with a liquid He free superconducting solenoid and a low energy antiproton beam transport line. The MUSASHI was capable of trapping and cooling more than $1\ifmmode\times\else\texttimes\fi{}{10}^{7}$ antiprotons and extracting them as an ultraslow antiproton beam with energy of 150--250 eV.