gebhart/patrepeval huggingface dataset:
The relationship between overactive bladder and sexual activity in women (2006)

The majority of women with symptoms of OAB viewed these symptoms as bothersome. However, the extent of symptom bother did not predict aspects of female sexual dysfunction (FSD). Instead, menopausal and partner status emerged as the best predictors of FSD in our sample.
A Multiscale Energy Systems Engineering Approach for Renewable Power Generation and Storage Optimization (2020)

Successful integration of intermittent renewable resources into the energy mix is instrumental to meet the growing global energy demand while reducing the carbon emissions. With this study, we propose a strategy of mixed-integer linear programming-based simultaneous design and operation to explore the techno-economic feasibility of novel energy system networks including solar photovoltaics, wind turbines, battery storage, and dense energy carriers. A multiscale energy system engineering approach is followed combining process synthesis, scheduling, and supply chain concepts to address the trade-offs between various technologies in renewable power generation and storage, as well as energy carrier production and transportation across different locations. We apply our strategy to analyze the integration of hydrogen-based dense energy carriers (DECs) produced in a high-potential region of renewable energy in Texas in tandem with local solar production and battery storage in a low-potential region in New York to minimize the levelized cost of renewable electricity. Case study results show that DECs can offer 30–50% cost reductions to local power generation and battery systems when used as clean backup fuels.
Effect of KIT and PDGFRA Mutations on Survival in Patients With Gastrointestinal Stromal Tumors Treated With Adjuvant Imatinib (2017)

clinicaltrials.gov Identifier: NCT00116935.
Luminescence of Novel Neodymium Sulfonylaminate Complexes in Organic Media (2000)

Luminescence of Nd(III) in an organic solvent having C-H bonds was achieved for the first time by complexing Nd(III) with long-chain perfluoroalkylated ligands such as bis(perfluorooctylsulfonyl)aminate (pos). The complex [Nd(pos)(3)] gave an emission quantum yield of 3.0+/-0.5 % in undeuterated acetone. The bulky pos ligands suppress the excitation of C-H vibrations, energy migration at diffusional collision, and the coordination of acetone molecules (see picture) to the Nd(III) center, which otherwise quench the luminescence.
Signaling Pathways of Immobilized FGF‐2 on Silicon‐Substituted Hydroxyapatite (2012)

Therapeutic strategies for bone regeneration involve the selection of suitable biomaterials, growth factors, and cell types to mimic the cellular microenvironment where molecular and mechanical signals control the reconstruction of bone tissue. The immobilization of basic fibroblast growth factor (FGF-2) on powdered silicon-substituted hydroxyapatite (Si-HA) allows to prepare a biofunctional biomaterial able to interact with bone cells in a very specific way. The biological activity of FGF-2/Si-HA, evaluated in Saos-2 osteoblasts and MC3T3-E1 preosteoblasts through the PLCγ and MAPK/ERK signal transduction pathways, shows that FGF-2 immobilized on Si-HA provides the right signals to cells stimulating crucial intracellular mechanisms of osteoblast proliferation and differentiation.
Performance characteristics of thick silicon double sided strip detectors (2007)

This work presents characterization studies of thick silicon double-sided strip detectors for a high-resolution small-animal SPECT. The dimension of these detectors is 60 mm × 60 mm × 1 mm. There are 1024 strips on each side that give the coordinates of the photon interaction, with each strip processed by a separate ASIC channel. Our measurement shows that intrinsic spatial resolution equivalent to the 59 µm strip pitch is attainable. Good flood uniformity can be achieved by proper setting of a 4-bit DAC in each ASIC channel to remove trigger threshold variations. This is particularly important for triggering at low energies. The thick silicon DSSD shows high potential for small-animal SPECT imaging.
Data from Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Pancreatic ductal adenocarcinoma (PDAC) is associated with a dismal prognosis and poor therapeutic response to current chemotherapy regimens in unselected patient populations. Recently, it has been shown that PDAC may be stratified into functionally and therapeutically relevant molecular subgroups and that some of these subtypes can be recapitulated by IHC for KRT81 [quasi-mesenchymal (QM)/squamous/basal-like] and HNF1A (non-QM, overlap with exocrine/ADEX subtype).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We validated the different outcome of the HNF1A/KRT81 PDAC subtypes in two independent cohorts of surgically treated patients and examined the treatment response to chemotherapy in a third cohort of unresectable patients. The first two cohorts included 262 and 130 patients, respectively, and the third independent cohort comprised advanced-stage PDAC patients who were treated with either FOLFIRINOX (64 patients) or gemcitabine (61 patients).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; In both cohorts with resected PDAC, the HNF1A-positive subtype showed the best, the KRT81-positive subtype the worst, and the double-negative subtype an intermediate survival (&lt;i&gt;P&lt;/i&gt; &lt; 0.013 and &lt;i&gt;P&lt;/i&gt; &lt; 0.009, respectively). In the chemotherapy cohort, the survival difference between the double-negative and the HNF1A-positive subtype was lost, whereas the dismal prognosis of KRT81-positive PDAC patients was retained (&lt;i&gt;P&lt;/i&gt; &lt; 0.021). Patients with a KRT81-positive subtype did not benefit from FOLFIRINOX therapy, whereas those with HNF1A-positive tumors responded better compared with gemcitabine-based treatment (&lt;i&gt;P&lt;/i&gt; &lt; 0.038).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; IHC stratification recapitulating molecular subtypes of PDAC using HNF1A and KRT81 is associated with significantly different outcomes and responses to chemotherapy. These results may pave the way toward future pretherapeutic biomarker-based stratification of PDAC patients. &lt;i&gt;Clin Cancer Res; 24(2); 351–9. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Scalable networked virtual environments using unstructured overlays (2007)

Large-scale Networked Virtual Environments (NVEs) are used to enable rich interactive experiences such as multiplayer games, military and industrial training, and collaborative engineering systems. In these applications, hosts must exchange data updates to maintain a consistent view of the virtual environment. In large-scale environments, the volume of data places a heavy load on the networking and computational resources available to each host. To improve scalability, systems have employed a variety of techniques, including data subscription, data segmentation, and multicast. In this paper, we describe a communication architecture for Networked Virtual Environments that takes advantage of unstructured peer-to-peer (P2P) overlay networks for message distribution. The overlay network design provides scalability while supporting easy deployment over today's Internet. The approach, when combined with data segmentation and data subscription, enables Internet deployment of large-scale NVEs.
An inductively coupled ultra‐thin, flexible, and passive RF resonator for MRI marking and guiding purposes: Clinical feasibility (2017)

The ultra-thin and flexible structure of this wireless flexible radiofrequency resonant marker offers effective and safe MR visualization with high feasibility for anatomic marking and guiding at various regions of the body. Magn Reson Med 80:361-370, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Bloch Oscillations, Landau-Zener Transition, and Topological Phase Evolution in a Pendula Array (2023)

We experimentally and theoretically study the dynamics of a one-dimensional array of pendula with a mild spatial gradient in their self-frequency and where neighboring pendula are connected with weak and alternating coupling. We map their dynamics to the topological Su-Schrieffer-Heeger (SSH) model of charged quantum particles on a lattice with alternating hopping rates in an external electric field. By directly tracking the dynamics of a wavepacket in the bulk of the lattice, we observe Bloch oscillations, Landau-Zener transitions, and coupling between the isospin (i.e. the inner wave function distribution within the unit cell) and the spatial degrees of freedom (the distribution between unit cells). We then use Bloch oscillations in the bulk to directly measure the non-trivial global topological phase winding and local geometric phase of the band. We measure an overall evolution of 3.1 $\pm$ 0.2 radians for the geometrical phase during the Bloch period, consistent with the expected Zak phase of $π$. Our results demonstrate the power of classical analogs of quantum models to directly observe the topological properties of the band structure, and sheds light on the similarities and the differences between quantum and classical topological effects.
Spin-Polarized to Valley-Polarized Transition in Graphene Bilayers atν=0in High Magnetic Fields (2011)

We investigate the transverse electric field (E) dependence of the ν=0 quantum Hall state (QHS) in dual-gated graphene bilayers in high magnetic fields. The longitudinal resistivity ρ(xx) measured at ν=0 shows an insulating behavior which is strongest in the vicinity of E=0, as well as at large E fields. At a fixed perpendicular magnetic field (B), the ν=0 QHS undergoes a transition as a function of the applied E, marked by a minimum, temperature-independent ρ(xx). This observation is explained by a transition from a spin-polarized ν=0 QHS at small E fields to a valley- (layer-)polarized ν=0 QHS at large E fields. The E field value at which the transition occurs follows a linear dependence on B.
Quantum Linear Magnetoresistance in Multilayer Epitaxial Graphene (2010)

We report the first observation of linear magnetoresistance (LMR) in multilayer epitaxial graphene grown on SiC. We show that multilayer epitaxial graphene exhibits large LMR from 2.2 K up to room temperature and that it can be best explained by a purely quantum mechanical model. We attribute the observation of LMR to inhomogeneities in the epitaxially grown graphene film. The large magnitude of the LMR suggests potential for novel applications in areas such as high-density data storage and magnetic sensors and actuators.
Multicore fiber-based mode multiplexer/demultiplexer (2015)

A multicore fiber (MCF)-based mode multiplexer/demultiplexer (MUX/DEMUX) that can overcome the alignment issue of the fiber-based mode MUX/DEMUX is proposed. Design concept and fabrication results of the MCF-based mode MUX/DEMUX for two-spatial-mode operation (LP<sub>01</sub> and LP<sub>11</sub>) (2M-MUX/DEMUX) and for three-spatial-mode operation (LP<sub>01</sub>, LP<sub>11a</sub>, and LP<sub>11b</sub>) (3M-MUX/DEMUX) are presented. The fabricated 2M-MUX/DEMUXes for C-band or L-band, using the same MCF with different elongation ratios demonstrate a coupling efficiency of greater than 90% over each band. Finally, a 3M-MUX/DEMUX with a fan-in/fan-out device is presented. The selective excitation of LP<sub>01</sub>, LP<sub>11a</sub>, and LP<sub>11b</sub> modes depending on input ports is experimentally demonstrated.
MAGE-A is More Highly Expressed Than NY-ESO-1 in a Systematic Immunohistochemical Analysis of 3668 Cases (2016)

Two cancer testis antigens, the New York esophageal squamous cell carcinoma-1 (NY-ESO-1) and the melanoma-antigen family A (MAGE-A), represent promising immunotherapy targets due to the low expression of these antigens in nonmalignant tissue. To assess overexpression patterns in various cancers, we performed a systematic immunohistochemical analysis for NY-ESO-1 and MAGE-A on tissue array samples of 3668 common epithelial carcinomas (CA) and germ cell tumors of high prevalence and mortality. Here, we find significantly higher expression of MAGE-A (>50% on tumor cells) compared with NY-ESO-1 in several CAs including cutaneous squamous cell carcinomas (SCC) (52.8%/2.8%), esophageal SCC (50%/0%), head and neck SCC (41.1%/<1%), bladder urothelial CA (40.4%/8.3%), cervical/anal SCC (37.5%/0%), lung SCC (34%/3.8%), lung adenocarcinomas (27.6%/3.9%), ovarian CA (26.4%/3.6%), endometrial CA (26.3%/1.3%), lung small cell CA (24.4%/2.4%), gastric adenocarcinomas (20%/4%), breast mucinous CA (19.3%/0%), hepatocellular CA (18.8%/1.2%), breast infiltrating ductal CA (16.4%/1.8%), colorectal adenocarcinomas (10.7%/<1%), cholangiocarcinomas (9.8%/0%), thymic CA (9%/4.5%), and mesotheliomas (7.9%/<1%). Furthermore, high expression of MAGE-A, but not NY-ESO-1, was seen in whole slide evaluations of an independent cohort of metastatic SCC (45.5%/3.6%) and metastatic CA (13.5%/0%) of various primaries with significantly higher expression of MAGE-A in metastatic SCC compared with other metastatic CA. MAGE-A is also more highly expressed in germ cell tumors, seminomas (69%/3.5%) and nonseminomas (40.1%/4.7%). In summary, MAGE-A is more highly expressed than NY-ESO-1 in a majority of human malignancies, and targeting MAGE-A may benefit a large number of patients.
Rapid Synthesis Method of Faujasitic Zeolite Frameworks Probed with Eu(III) Fluorescence Spectroscopy (2015)

We report a method for rapid synthesis of faujasitic frameworks with Si/Al ranging from 1.5 to 2.5. Shorter synthesis time is achieved by tuning the supersaturation during a dehydration–rehydration hydrothermal process (DRHT). The dehydration step involves extraction of water from the system during the synthesis process, enhancing the nucleation rate, and a subsequent rehydration step, where the water is added back, facilitating the growth. The crystallization pathway in the DRHT process is investigated by fluorescence spectroscopy using the Eu(III) cation as the probe. The electric dipole transition 7F4–5D0 (680–710 nm) of Eu(III) is sensitive to the ligand environment and is used as a marker for the intermediate and final structures formed during zeolite crystallization. The ligand field splitting of this band was found to have distinct signatures for the different Eu3+ cation sites within faujasite. The appearance of a characteristic 5-fold splitting of the 7F4–5D0 band is a signature of Eu(III) cations inside sodalite cages. Using this spectral pattern, we conclude that in the DRHT zeolite synthesis “sodalite-like” structures start to form in the nucleation stage for faujasite frameworks with low Si/Al ratios.
Exploration of an Opportunistic Overlaid Paradigm for Complex Networks via Stochastic Geometry (2012)

Abstract : In this project, we focused on large complex networks and mainly investigated the following major issues: 1) We studied the overlaid complex networking systems where a primary network tier is coexisting with an opportunistic network tier. With stochastic geometry tools, we first showed that both tiers could achieve the same throughput scaling and then showed that the primary throughput scaling can be improved by allowing the opportunistic tier to help with relaying primary traffic. 2) We then studied the enabling techniques for primary vs. opportunistic coexisting network systems, where we mainly investigated how the opportunistic network senses the primary spectrum usage and detect primary occupancy in a distributed fashion, for which we established the respective asymptotic convergence results based on the Random Dynamic System theories. 3) We finally studied the related resource allocation strategies in large random networks, where we redefine the related transmission capacity concepts to quantify the system performance.
Digital identity guidelines: authentication and lifecycle management (2017)

The Information Technology Laboratory (ITL) at the National Institute of Standards and Technology (NIST) promotes the U.S. economy and public welfare by providing technical leadership for the Nation's measurement and standards infrastructure. ITL develops tests, test methods, reference data, proof of concept implementations, and technical analyses to advance the development and productive use of information technology. ITL's
A 10W GaN based X-band T/R module for AESA (2016)

The paper presents the results of a project leading to design and fabrication of a transmitting-receiving module destined for application in an active electronically scanned array (AESA). The module is supposed to operate in the band from 9 GHz to 10 GHz. GaAs technology core chip is applied and it is used to drive power amplifiers based on GaN technology. The shape of the module enclosure follows the requirements of limited space available in an X-band AESA.
Disordered biopolymer filament bundles: Topological defects and kinks (2020)

Bundles of stiff filaments are ubiquitous in the living world, found both in the cytoskeleton and in the extracellular medium. These bundles are typically held together by smaller cross-linking molecules. We demonstrate analytically, numerically and experimentally that such bundles can be kinked, i.e., have localized regions of high curvature that are long-lived metastable states. We propose three possible mechanisms of kink stabilization: a difference in trapped length of the filament segments between two cross links; a dislocation where the endpoint of a filament occurs within the bundle, and the braiding of the filaments in the bundle. At a high concentration of cross links, the last two effects lead to the topologically protected kinked states. Finally, we explore numerically and analytically the transition of the metastable kinked state to the stable straight bundle.
Performance analysis of optimistic concurrency control schemes with different rerun policies (2002)

The pure optimistic concurrency control (OCC) scheme, which only aborts a transaction at its commit time, can do better than aborting transactions as soon as conflict is detected (broadcast OCC). To further exploit this phenomenon, hybrid CC schemes are devised which use a different CC scheme to handle rerun transactions. These include switching to static or dynamic locking (static and dynamic hybrid OCC schemes, respectively) or to broadcast OCC during rerun, while doing pure OCC for the first run. In the high-data contention environment, where locking is inferior to OCC, it is found that the static and dynamic hybrid OCC can do better than OCC.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Microprocessor system applications and challenges for through-silicon-via-based three-dimensional integration (2011)

Promise of form-factor reduction and hybrid process integration by three-dimensional (3D)-stacked integrated circuits (3DICs) has spurred interest in both academia and industry. In this study, through-silicon-via (TSV)-based 3D integration is discussed from a microprocessor centric view. The authors present the challenges faced by technology scaling and provide 3D integration as a possible solution. The applications for 3DICs are discussed with details of a few prototypes. The issues and challenges associated with 3D integration technologies are also addressed. TSV-based 3D integration technology will allow integration of diverse functionality to realise energy-efficient and affordable compact systems that will continue to deliver higher performance.
A Robust Multipoint Linkage Statistic (tlod) for Mapping Complex Trait Loci (2001)

Classical parametric two-point linkage analysis is a powerful analysis tool, however there are clear disadvantages too, including the sensitivity to allele frequency mis-specification. Conversely, multipoint linkage analysis is not sensitive to allele frequency mis-specification, but it is sensitive to genetic model mis-specification. Göring and Terwilliger [Am J Hum Genet 66:1095-106, 2000] proposed a new robust multipoint statistic that increased the robustness of multipoint analyses. In this paper we have referred to this new statistic as the tlod. We applied this new statistic to the Genetic Analysis Workshop (GAW) 12 data using affected status (AFF) as the phenotype of interest. The heterogeneity tlod and two-point hlod scores correlated highly across the genome (p < 0.0001), as expected, but the het-tlod had a lower number false positives. In addition, the tlod analysis handled missing data better, as would be expected for a multipoint method. When one-third of the genotype data was removed (dead people) the tlod analysis was less affected than the two-point analysis. When tlod scores were compared with multipoint lod scores in true gene locations, the robustness of the tlod to model mis-specification was clearly evident. When the "best" replicate from the general population was analyzed, a borderline genome-wide significant two-point hlod result (3.6) was found 4 cM from MG6 and MG7 on chromosome 6. The heterogeneity tlod score was lower than the two-point hlod score (1.8), but greater than the heterogeneity multipoint lod score (0.4). However, when replicate 1 of the isolated population was analyzed none of the true gene locations were identified with either statistic.
Task-aware garbage collection in a multi-tasking virtual machine (2006)

A multi-tasking virtual machine (MVM) executes multiple programs in isolation, within a single operating system process. The goal of a MVM is to improve startup time, overall system throughput, and performance, by effective reuse and sharing of system resources across programs (tasks). However, multitasking also mandates a memory management system capable of offering a guarantee of isolation with respect to garbage collection costs, accounting of memory usage, and timely reclamation of heap resources upon task termination.To this end, we investigate and evaluate, novel task-aware extensions to a state-of-the-art MVM garbage collector (GC). Our task-aware GC exploits the generational garbage collection hypothesis, in the context of multiple tasks, to provide performance isolation by maintaining task-private young generations. Task aware GC facilitates concurrent per-task allocation and promotion, and minimizes synchronization and scanning overhead. In addition, we efficiently track per-task heap usage to enable GC-free reclamation upon task termination. Moreover, we couple these techniques with a light-weight synchronization mechanism that enables per-task minor collection, concurrently with allocation by other tasks.We empirically evaluate the efficiency, scalability, and through-put that our task-aware GC system enables.
Virus Production Under Suspension Conditions (2014)

With the observation by Enders et al. in the late 1940s that poliovirus can be propagated in cell culture, the production of large amounts of viruses with an improved safety profile for vaccine purposes became possible, although adherent cell culture with limited scalability was used. The first major improvement in terms of industrial production scale was the development of microcarrier technology by van Wezel in the late 1960s, allowing the cultivation of adherent cells on microcarriers in suspension cultures at a 1000-liter scale. However, the real technological breakthrough is the use of suspension cells for virus production, which allows production scales beyond several 10 000s of liters. This achievement presents a considerable technological simplification and modern production processes of virus and viral vectors are often based on this technology and are the only means available when really large amounts of viruses or viral vectors are required. This chapter provides an overview of the present state of medium and large scale production of viruses and viral vectors for different purposes, including vaccine and gene therapy purposes, using suspension processes. It presents suspension culture based production technologies of some important viruses and viral vectors in more detail and compares them to traditional technologies still in use.