gebhart/patrepeval huggingface dataset:
Mitigation of Odors from Lime Stabilized Biosolids (2000)

Mitigation of Odors from Lime Stabilized BiosolidsThe Blue Plains WWTP, in Washington, DC, relies on land application for about 85% of their biosolids. Therefore, it is essential to obtain a properly stabilized Class B product that is largely odor-free. This poster will discuss the odorous compounds released from biosolids and the in-plant (on-site) conditions that promote odorous biosolids products. Controls for odor reduction and methods for...Author(s)Sudhir MurthyMary StrawnChris PeotDorian TolbertWalter BaileyMichael McGrathSourceProceedings of the Water Environment FederationSubjectSession 56 - Residuals and Biosolids Management Symposium: Beneficial Reuse of BiosolidsDocument typeConference PaperPublisherWater Environment FederationPrint publication date Jan, 2000ISSN1938-6478SICI1938-6478(20000101)2000:9L.574;1-DOI10.2175/193864700784545937Volume / Issue2000 / 9Content sourceWEFTECFirst / last page(s)574 - 574Copyright2000Word count336
Structural impact of GTP binding on downstream KRAS signaling (2020)

Oncogenic RAS proteins, involved in ∼30% of human tumors, are molecular switches of various signal transduction pathways. Here we apply a new protocol for the NMR study of KRAS in its (inactive) GDP- and (activated) GTP-bound form, allowing a comprehensive analysis of the backbone dynamics of its WT-, G12C- and G12D variants. We found that Tyr32 shows opposite mobility with respect to the backbone of its surroundings: it is more flexible in the GDP-bound form while more rigid in GTP-complexes (especially in WT- and G12D-GTP). Using the G12C/Y32F double mutant, we showed that the presence of the hydroxyl group of Tyr32 has a marked effect on the G12C-KRAS-GTP system as well. Molecular dynamics simulations indicate that Tyr32 is linked to the γ-phosphate of GTP in the activated states - an arrangement shown, using QM/MM calculations, to support catalysis. Anchoring Tyr32 to the γ-phosphate contributes to the capture of the catalytic waters participating in the intrinsic hydrolysis of GTP and supports a simultaneous triple proton transfer step (catalytic water → assisting water → Tyr32 → O1G of the γ-phosphate) leading to straightforward product formation. The coupled flip of negatively charged residues of switch I toward the inside of the effector binding pocket potentiates ligand recognition, while positioning of Thr35 to enter the coordination sphere of the Mg<sup>2+</sup> widens the pocket. Position 12 mutations do not disturb the capture of Tyr32 by the γ-phosphate, but (partially) displace Gln61, which opens up the catalytic pocket and destabilizes catalytic water molecules thus impairing intrinsic hydrolysis.
Acidodiethylenetriaminegold(III) Complexes: Preparation, Solution Chemistry, and Electronic Structure (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcidodiethylenetriaminegold(III) Complexes: Preparation, Solution Chemistry, and Electronic StructureW. H. Baddley, Fred Basolo, Harry B. Gray, Clarita Nolting, and A. J. PoeCite this: Inorg. Chem. 1963, 2, 5, 921–928Publication Date (Print):October 1, 1963Publication History Published online1 May 2002Published inissue 1 October 1963https://pubs.acs.org/doi/10.1021/ic50009a011https://doi.org/10.1021/ic50009a011research-articleACS PublicationsRequest reuse permissionsArticle Views247Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Role of Tunable Acid Catalysis in Decomposition of α-Hydroxyalkyl Hydroperoxides and Mechanistic Implications for Tropospheric Chemistry (2014)

Electronic structure calculations have been used to investigate possible gas-phase decomposition pathways of α-hydroxyalkyl hydroperoxides (HHPs), an important source of tropospheric hydrogen peroxide and carbonyl compounds. The uncatalyzed as well as water- and acid-catalyzed decomposition of multiple HHPs have been examined at the M06-2X/aug-cc-pVTZ level of theory. The calculations indicate that, compared to an uncatalyzed or water-catalyzed reaction, the free-energy barrier of an acid-catalyzed decomposition leading to an aldehyde or ketone and hydrogen peroxide is dramatically lowered. The calculations also find a direct correlation between the catalytic effect of an acid and the distance separating its hydrogen acceptor and donor sites. Interestingly, the catalytic effect of an acid on the HHP decomposition resulting in the formation of carboxylic acid and water is relatively much smaller. Moreover, since the free-energy barrier of the acid-catalyzed aldehyde- or ketone-forming decomposition is ∼ 25% lower than that required to break the O-OH linkage of the HHP leading to the formation of hydroxyl radical, these results suggest that HHP decomposition is likely not an important source of tropospheric hydroxyl radical. Finally, transition state theory estimates indicate that the effective rate constants for the acid-catalyzed aldehyde- or ketone-forming HHP decomposition pathways are 2-3 orders of magnitude faster than those for the water-catalyzed reaction, indicating that an acid-catalyzed HHP decomposition is kinetically favored as well.
Aser Interaction and Related Plasma Phenomena: 12th International Conference. Proceedings (1996)

These proceedings represent papers presented at the 12th International Conference on Laser Interaction and Related Plasma Phenomena held in Osaka, Japan. The topics covered included: (1) Inertial confinement fusion programs, (2) Critical elements for ignition, (3) Energy drivers, (4) Laser{minus}matter interactions, (5) High{minus}intensity physics, and (6) Laser applications and other new fields. The proceedings represent a vital documentation of the newest and most exciting contemporary results and research directions in the fields of laser interactions and related plasma phenomena. The conference was sponsored by the International Atomic Energy Agency(IAEA), the Institute of Laser Engineering, and Osaka University. There were 287 papers presented and all have been abstracted for the Energy Science and Technology database.(AIP)
Apparatus for the in situ kinetic study of reactions involving air sensitive materials using energy-dispersive powder diffraction (1994)

A novel sample chamber has been developed for the study of chemical reactions involving air sensitive samples using energy-dispersive powder diffraction. The apparatus consists of a reaction vessel, automatic reactant dispensing system, heating jacket, stirrer, and gas purge system. The use of this apparatus is illustrated with data collected on station 9.7 of the UK Synchrotron Radiation Source during a study on the intercalation of cobaltocene into tin disulfide.
Adenosine A2A Receptor Agonists Regulate Cholesterol Homeostasis in Mouse Bone Marrow Derived Macrophages (BMDM) (2013)

Objective Adenosine A 2A receptor (A 2A R) mediate anti‐inflammatory changes in the vasculature. Here we report that A 2A R ligation via administration of the specific agonist ATL313 or the adenosine‐releasing drug methotrexate (MTX) to apolipoprotein (apo) E −/− mice enhances expression of cholesterol efflux proteins: cholesterol 27‐hydroxylase and ATP binding cassette transporter (ABC) A1 and reduces scavenger receptor expression in BMDM. Methods Male homozygous apoE −/− (C57BL/6J) mice were randomized into 3 groups (n=8) and fed from age 10–20 weeks: regular chow [control], ATL313 300 μg/kg/day [AEA] or MTX 1mg/kg/week [AEM]. Femurs were dissected and cell suspensions obtained by flushing bones with DMEM. BMDM were generated by culturing cells for 7 days with MCSF. Expression of F40/80, ABCA1 and G1, 27‐hydroxylase, CD36 and LOX1 were evaluated by QRT‐PCR. Western blot confirmed results of PCR. Results In apoE −/− mice, A 2A R activation raises 27‐hydroxylase mRNA (by 23.5±3.5% in AEA and 18.7±2.1% in AEM) and ABCA1 (by 38.9±5.4% in AEA and 45.7±8.3% in AEM). ABCG1 expression was unchanged. CD36 and LOX‐1 mRNA were downregulated in both AEA and AEM groups, compared to control. Conclusions A 2A R ligation has an anti‐atherogenic effect on cholesterol transport that prevents lipid accumulation. Novel therapeutic approaches to cardioprotection may be directed toward improved cholesterol balance through A 2A R activation.
Standardizing Scavenger Receptor Nomenclature (2014)

Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a variety of ligands, including endogenous and modified host-derived molecules and microbial pathogens. There are currently eight classes of scavenger receptors, many of which have multiple names, leading to inconsistencies and confusion in the literature. To address this problem, a workshop was organized by the U.S. National Institute of Allergy and Infectious Diseases, National Institutes of Health to help develop a clear definition of scavenger receptors and a standardized nomenclature based on that definition. Fifteen experts in the scavenger receptor field attended the workshop and, after extensive discussion, reached a consensus regarding the definition of scavenger receptors and a proposed scavenger receptor nomenclature. Scavenger receptors were defined as cell surface receptors that typically bind multiple ligands and promote the removal of non-self or altered-self targets. They often function by mechanisms that include endocytosis, phagocytosis, adhesion, and signaling that ultimately lead to the elimination of degraded or harmful substances. Based on this definition, nomenclature and classification of these receptors into 10 classes were proposed. The discussion and nomenclature recommendations described in this report only refer to mammalian scavenger receptors. The purpose of this article is to describe the proposed mammalian nomenclature and classification developed at the workshop and to solicit additional feedback from the broader research community.
Mold Layout Design (2007)

No AccessInjection Mold Design EngineeringAug 2007Mold Layout DesignDavid O. KazmerDavid O. Kazmerhttps://doi.org/10.3139/9783446434196.004SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2007Pages: 67-89Print ISBN: 978-3-446-41266-8eISBN: 978-3-446-43419-6 Copyright & Permissions© 2007 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
A new high capacity compact power modules for high power EV/HEV inverters (2016)

This paper presents a new power semiconductor IGBT module family dedicated for Electric Vehicle (EV) and Hybrid Electric Vehicle (HEV) power-train inverter applications, especially for higher power requirements. The new IGBT module family adopts a 6-in-1 circuit configuration with an optimized internal layout, Direct Lead Bond (DLB) structure and an integrated Al fin for direct liquid cooling. As a result, this new power module family has simultaneously achieved high performance, low self-inductance, small size and light weight. Compared to conventional products with similar power capabilities, the adoption of these innovative technologies has led to a 20% improvement in thermal performance, 30% reduction of self-inductance, 50% reduction of the module's footprint, and a 70% reduction of the module's weight.
Microwave-assisted solid-state synthesis and characterization of intermetallic compounds of Li3Bi and Li3Sb (2003)

Li3Bi and Li3Sb are two types of intermetallic lithium alloys, which were prepared for the first time by a microwave-assisted solid-state reaction. They were characterized by PXRD and SEM techniques. Pure phases of Li3Bi and Li3Sb were obtained after only 2 min and 1 min irradiation at 80% microwave power, respectively. The microwave method was found to be simple, fast and efficient for the preparation of these compounds. The oxidization processes of the two intermetallic lithium alloys in air were investigated. After exposure of the two intermetallic compounds to air for 5 hours only the corresponding Bi and Sb were detected by XRD analyses, the Li metal having been converted to amorphous Li2O. SEM observations show that the products are homogeneous, meaning that Bi and Sb are homogeneously dispersed in the amorphous products. The oxidized products may be potential composite anode materials for Li ion batteries.
Magnetic imaging at linearly polarized x-ray sources (2010)

We present a method for high-resolution magnetic imaging at linearly polarized partially coherent x-ray sources. The magnetic imaging was realized via Fourier transform holography. In order to achieve elliptical x-ray polarization, three different filters were designed based on the x-ray magnetic circular dichroism effect. We present proof-of-principle images of magnetic nanostructures and discuss the application of the method for future experiments at free-electron laser sources.
Response of a Continuous Macrophage-Like Cell Line to Mif (1979)

Abstract A cloned murine macrophage-like cell line, FC-1, which arose during fusion of a drug-marked myeloma cell line with primary splenic cells was shown to migrate well from capillary tubes both in medium containing 10% horse serum or in serum-free medium containing 0.5% BSA. This cell line was responsive to MIF produced by mouse spleen cells stimulated with either insolubilized Con A or with alloantigens. Bio Gel fractionation of MIF supernatants showed the same samples to contain inhibitory material for both FC-1 cells and for primary macrophages and that this product had a m.w. of 25,000 to 50,000. Because the migration of FC-1 was inhibited by MIF prepared and tested in serum-free medium or in plasminogen-depleted serum, migration inhibition must result from the direct interaction of MIF with macrophages rather than indirectly through an activation of serum enzymes. This was confirmed when primary macrophages that require serum were shown both to migrate well and to respond to MIF in plasminogen-depleted serum. Because of the homogeneity of the cloned FC-1 cell line and its ability to migrate and respond to MIF in serumfree medium, this macrophage-like cell line offers unique advantages for studying the regulation of macrophage functions by products of activated lymphocytes.
ChemInform Abstract: New Functionalization of Myoglobin by Chemical Modification of Heme‐Propionates (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Electrochemical characteristics of acid electrolytes for fuel cells. Final report, January 1, 1989-June 30, 1991 (1992)

The electrochemical evaluation of new perfluorinated fuel cell electrolytes provided by GRI contractors at Clemson and Iowa shows the kinetics for O2 reduction on Pt improves with these acids compared to with phosphoric acid. The improvement is mainly due to the lesser tendency of these acids to adsorb on Pt. Kinetics do not have a strong dependence on pH or O2 solubility when mass transport is not involved. Concentrated sulfonyl acids were usually found to wet Teflon resulting in the flooding of Teflon-bonded gas fed electrodes and poor performance at high current densities. These perfluorinated electrolytes were, however, found to be useful as performance enhancing additives to concentrated phosphoric acid in some cases. The alpha,omega-bis-phosphonic acid with a perfluoroethylene bridge gave superior performance compared to phosphoric acid at elevated temperatures (up to 200 degrees C) for 500 hours. Bis-phosphonic acids with higher CF2 to PO3H2 ratios dehydrated more readily at elevated temperatures, resulting in resistive voltage losses. New perfluorinated phosphonic acid containing olefins were found to be polymerizable. This suggests that with a reasonable synthetic effort, new kinds of ionomer membranes are attainable, and these may be superior to Nafion for fuel cell applications.
Enriched environment and stress exposure influence splenic B lymphocyte composition (2017)

Prolonged chronic stress has deleterious effects on immune function and is associated with numerous negative health outcomes. The spleen harbors one-fourth of the body's lymphocytes and mediates both innate and adaptive immune responses. However, the subset of splenic lymphocytes that respond, either adaptively or maladaptively, to various stressors remains largely unknown. Here we investigated the effects of unpredictable chronic mild stress (CMS) exposure on spleen composition in male mice housed in two different caging conditions: standard caging (Cntl) and enriched environment (EE). EE-caged mice exhibited the greatest absolute number of splenocytes and CMS exposure significantly lowered splenocyte numbers in both caging conditions. Glucocorticoid production, measured by mean fecal corticosterone metabolites (FCM), was significantly lower in EE-caged mice vs. Cntl-caged mice. Surprisingly, CMS exposure resulted in an increase in mean FCM in EE-caged mice, but no significant change in Cntl-caged mice. CMS altered the splenic B:T lymphocyte ratio; it reduced the frequency of B cells, but increased the frequency of T cells in EE-caged mice. Splenocyte number and B:T lymphocyte ratio showed a negative relationship with mean FCM. EE-caged mice had a lower frequency of immature and germinal B cells than Cntl-caged mice. CMS markedly increased the frequency of immature and marginal zone B cells, but decreased the frequency of follicular B cells in both caging conditions. Mean FCM correlated positively with frequency of immature, marginal zone and germinal center B cells, but negatively with frequency of follicular B cells. To conclude, splenic immune cells, particularly B lymphocyte composition, are modulated by caging environment and stress and may prime mice differently to respond to immune challenges.
Model-Based Calibration Approach to Improve Tone Consistency for Color Electrophotography (2011)

This paper aims to improve tone consistency for color electrophotography (EP). Color accuracy is crucial for printing. Calibrations are performed in EP printers to maintain consistent tone reproduction curves (TRCs). The calibration performance directly impacts the quality of color rendering. In this study, a model-based calibration approach is proposed to stabilize the TRCs. Regression models are developed to predict the primary color TRCs based on operating conditions and/or on-board sensor measurements. During a calibration, TRCs are predicted by the regression models, and the deviation is compensated by adjusting EP control parameters and modifying the tone correction mapping. The effectiveness of the proposed approach is validated using an off-the-shelf in-line four color EP printer under various environmental conditions and consumable factors. The experimental results demonstrate a 63.3% reduction in root-mean-squared error over the existing calibration method.
DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients (2018)

Copy number alterations (CNAs) are crucial for colorectal cancer (CRC) development. In this study, DEAD box polypeptide 27 (DDX27) was identified to be highly amplified in both TCGA CRC (474/615) and primary CRC (47/103), which was positively correlated with its mRNA overexpression. High DDX27 mRNA (N = 199) and protein expression (N = 260) predicted poor survival in CRC patients. Ectopic expression of DDX27 increased CRC cells proliferation, migration and invasion, but suppressed apoptosis. Conversely, silencing of DDX27 exerted opposite effects in vitro and significantly inhibited murine xenograft tumor growth and lung metastasis in vivo. Up-regulation of DDX27 enhanced and prolonged TNF-α-mediated NF-κB signaling. Nucleophosmin (NPM1) was identified as a binding partner of DDX27. DDX27 increased nuclear NPM1 and NF-κB-p65 interaction to enhance DNA binding activity of NF-κB. Silencing NPM1 abrogated DDX27-activating NF-κB signaling and its tumor-promoting function. Together, DDX27 is overexpressed and plays a pivotal oncogenic role in CRC.
Supplementary Table S6 from Cancers as Wounds that Do Not Heal: Differences and Similarities between Renal Regeneration/Repair and Renal Cell Carcinoma (2023)

Supplementary Table S6 from Cancers as Wounds that Do Not Heal: Differences and Similarities between Renal Regeneration/Repair and Renal Cell Carcinoma
ChemInform Abstract: Asymmetric Synthesis of an Unusual Amino Acid: Synthesis of Four Isomers of β‐Methyl‐3‐(2′‐naphthyl)alanine. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fault tolerance in a class of sorting networks (1994)

The early study of fault tolerance in efficient sorting networks only achieved single-fault tolerance. By eliminating critical comparators, L. Rudolph (1985) presented a 1-fault tolerant design of the balanced sorting network (BSN) at the cost of one redundant stage of N/2 comparators and two permuters external to the network. In this paper, we show, however, that 1-fault tolerance of BSN can be achieved without introducing redundancy and external permuters. Furthermore, we provide solutions to the open question of how to achieve multiple-fault tolerance in BSN. We analyze the problem from a higher-level by introducing a new concept of critical stages, and find that all stages in previous designs are critical. A 2-fault tolerant design of BSN is then discovered after eliminating its critical stages. The new design has a similar network architecture (i.e., a multistage network with the output recirculated back to the input) and the same hardware cost as Rudolph's, but it has many distinguished features. The performance analysis shows that the new designs achieve much higher probabilities of correct sorting in the presence of faulty comparators than the previous reported designs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>