gebhart/patrepeval huggingface dataset:
Construction of Motion Database Based on Real-World Haptics (2011)

This paper proposes a motion database based on real-world haptics. In order to treat advanced types of haptic information, the motion database contains not only the name of motion and position trajectory of a human operator but also force information. Moreover, the motion database is constructed and managed by a motion database management system, which performs the tasks of inserting, updating, retrieving, and deleting information pertaining to human motion. The motion database management system consists of a motion-copying system, which stores and reproduces the simple motions of the human operator. In this research, the validity and feasibility of the proposed method are verified. By using the proposed method, the motions of human operators in the industrial and medical fields can be stored, dynamically reproduced, and referred.
Lithium micro-battery development at the Jet Propulsion Laboratory (2002)

Recent successes in the effort to miniaturize spacecraft components using MEMS technology, integrated passive components, and low power electronics have driven the need for very low power, low profile, low mass micro-power sources for micro/nanospacecraft applications. Recent work at JPL has focused upon developing thin film/micro-batteries compatible with temperature sensitive substrates. A process to prepare crystalline LiCoO/sub 2/ films with RF sputtering and moderate (<700/spl deg/C) annealing temperature has been developed. Thin film batteries with cathode films prepared with this process have specific capacities approaching the practical limit for LiCoO/sub 2/, with acceptable rate capabilities and discharge voltage profiles. Solid state micro-scale batteries have also been fabricated, with feature sizes on the order of 50 microns.
Relay Assisted Cooperative OSTBC Communication with SNR Imbalance and Channel Estimation Errors (2009)

In this paper, a two-hop relay assisted cooperative orthogonal space-time block codes (OSTBC) transmission scheme is considered for the downlink communication of a cellular system, where the base station (BS) and the relay station (RS) cooperate and transmit data to the user equipment (UE) in a distributed fashion. We analyze the impact of the SNR imbalance between the BS-UE and RS-UE links, as well as the imperfect channel estimation at the UE receiver. The performance is analyzed in the presence of Rayleigh flat fading and our results show that the SNR imbalance does not impact the spatial diversity order. On the other hand, channel estimation errors have a larger impact on the system performance. Simulation results are then provided to confirm the analysis.
A general multi-mode lumped equivalent circuit model for circular cMUT cells (2016)

In this work, we present a general multi-mode lumped equivalent circuit model for an arbitrary excited circular cMUT cell operated in a small signal regime. It can be considered as a model extension of the modal analysis based equivalent circuit model already presented in [1]. In order to derive this model, a comprehensive description of the radiation impedance by the Bouwkamp's impedance theorem [2] is provided. Comparing with other existing lumped equivalent circuit models, this model can simulate a wide frequency range, i.e., containing those harmonic modes, response of cMUTs under an unconventional excitation. A case study based on a half electrode excited circular cMUT cell is presented, and frequency response results from the modelling are well validated by COMSOL simulation. Potentially, this method can also handle the problem of a group of cMUT cells.
Water-Mediated Dimerization of Ubiquitin Ions Captured by Cryogenic Ion Mobility-Mass Spectrometry (2015)

The dynamics, structures, and functions of most biological molecules are strongly influenced by the nature of the peptide's or protein's interaction with water. Here, cryogenic ion mobility-mass spectrometry studies of ubiquitin have directly captured a water-mediated protein-protein binding event involving hydrated, noncovalently bound dimer ions in solution, and this interaction has potential relevance to one of the most important protein-protein interactions in nature. As solvent is removed, dimer ions, viz. [2 M + 14H](14+), can be stabilized by only a few attached water molecules prior to dissociation into individual monomeric ions. The hydrophobic patch of ubiquitin formed by the side chains of Leu-8, Ile-44, and Val-70 meet all the necessary conditions for a protein-protein binding "hot spot," including the requirement for occlusion of water to nearby hydrophilic sites, and it is suggested that this interaction is responsible for formation of the hydrated noncovalent ubiquitin dimer.
Supplementary Table 2 from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors (2023)

&lt;p&gt;PDF file - 75K, High responsiveness of c-Met-addicted cell lines to treatment with EMD 1214063 and EMD 1204831. The impact of EMD 1214063 and EMD 1204831 on tumor cell viability (IC50) was tested in vitro, using a panel of tumor cell lines specifically characterized for their levels of c-Met expression, c-Met auto-phosphorylation, and HGF production. The human colorectal carcinoma cell line HT29 and the human lung carcinoma cell line A549 displayed low levels of c-Met/phospho-c-Met, while the lung carcinoma cell line EBC-1 and the gastric carcinoma Hs746T and MKN-45 exhibited high levels of both c-Met and phospho-c-Met, due to the described c-Met gene amplification (3). The c-Met-"addicted" cell lines (EBC-1 (4), Hs746T (3) and MKN-45 (3)), exhibited high sensitivity to both EMD 1214063 and EMD 1204831. In contrast, high concentrations of EMD 1214063 were required to induce 50% reduction in the viability of HT29 and A549. Similar to EMD 1214063, EMD 1204831 also showed strong impact on the viability of Hs746T cells (IC50 = 4.72E-09), EBC-1 (IC50 = 1.21E-08), and MKN-45 (IC50 = 4.93E-08). Data are cumulative of three separate experiments; the IC50 represent the mean of three separate experiments.&lt;/p&gt;
Streaming Authenticated Data Structures (2013)

We consider the problem of streaming verifiable computation, where both a verifier and a prover observe a stream of n elements x1, x2,..., xn and the verifier can later delegate some computation over the stream to the prover. The prover must return the output of the computation, along with a cryptographic proof to be used for verifying the correctness of the output. Due to the nature of the streaming setting, the verifier can only keep small local state (e.g., logarithmic) which must be updatable in a streaming manner and with no interaction with the prover. Such constraints make the problem particularly challenging and rule out applying existing verifiable computation schemes. We propose streaming authenticated data structures, a model that enables efficient verification of data structure queries on a stream. Compared to previous work, we achieve an exponential improvement in the prover’s running time: While previous solutions have linear prover complexity (in the size of the stream), even for queries executing in sublinear time (e.g., set membership), we propose a scheme with O(log M log n) prover complexity, where n is the size of the stream and M is the size of the universe of elements. Our schemes support a series of expressive queries, such as (non-)membership, successor, range search and frequency queries, over an ordered universe and even in higher dimensions. The central idea of our construction is a new authentication tree, called generalized hash tree. We instantiate our generalized hash tree with a hash function based on lattices assumptions, showing that it enjoys suitable algebraic properties that traditional Merkle trees lack. We exploit such properties to achieve our results.
Production of d-aldotetrose from l-erythrulose using various isomerases (2023)

d-Aldotetroses are rare sugars that are obtained via chemical synthesis in low yield. In this study, we demonstrated that d-aldotetroses could be produced using 3 isomerases. First, l-erythrulose was epimerized using d-tagatose 3-epimerase from Pseudomonas cichorii ST-24. The specific optical rotation of the reaction solution gradually decreased to zero, indicating that approximately 50% of the l-erythrulose was converted to d-erythrulose. d, l-Erythrulose mixture was isomerized with d-arabinose isomerase from Klebsiella pneumoniae 40bXX to produce d-threose, resulting in a conversion rate of 9.35%. d-Erythrose production using l-rhamnose isomerase from Pseudomonas stutzeri LL172 resulted in a conversion rate of 12.9%. Because of the low purity of the purchased d-erythrose, the product was reduced by the Raney nickel catalyst compared with authentic erythritol. We confirmed the products using HPLC and 13C-NMR spectra. This is the first report of d-aldotetrose production using an enzymatic reaction.
Polyethyleneimine as a Promoter Layer for the Immobilization of Cellobiose Dehydrogenase from Myriococcum thermophilum on Graphite Electrodes (2014)

Cellobiose dehydrogenase (CDH) is a promising enzyme for the construction of biofuel cell anodes and biosensors capable of oxidizing aldoses as cellobiose as well as lactose and glucose and with the ability to connect to an electrode through a direct electron transfer mechanism. In the present study, we point out the beneficial effect of a premodification of spectrographic graphite electrodes with the polycation polyethyleneimine (PEI) prior to adsorption of CDH from Myriococcum thermophilum (MtCDH). The application of PEI shifts the pH optimum of the response of the MtCDH modified electrode from pH 5.5 to 8. The catalytic currents to lactose were increased up to 140 times, and the K(M)(app) values were increased up to 9 times. The previously investigated, beneficial effect of divalent cations on the activity of CDH was also present for graphite/PEI/MtCDH electrodes but was less pronounced. Polarization curves revealed a second unexpected catalytic wave for graphite/PEI/MtCDH electrodes especially pronounced at pH 8. Square wave voltammetric studies revealed the presence of an unknown redox functionality present at 192 mV vs Ag|AgCl (0.1 M KCl) at pH 8, probably originating from an oxidized adenosine derivative. Adenosine is a structural part of the flavin adenine dinucleotide (FAD) cofactor of the dehydrogenase domain of CDH. It is suggested that for some enzyme molecules FAD leaks out from the active site, adsorbs onto graphite, and is oxidized on the electrode surface into a product able to mediate the electron transfer between CDH and the electrode. PEI is suggested and discussed to act in several manners by (a) increasing the surface loading of the enzyme, (b) possibly increasing the electron transfer rate between CDH and the electrode, and (c) facilitating the creation or immobilization of redox active adenosine derivatives able to additionally mediate the electron transfer between CDH and the electrode.
An Electrically Pumped Ge-on-Si Laser (2012)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. Michel, R. E. Camacho-Aguilera, Y. Cai, N. Patel, J. T. Bessette, M. Romagnoli, B. (R. ) Dutt, and L. C. Kimerling, "An Electrically Pumped Ge-on-Si Laser," in National Fiber Optic Engineers Conference, OSA Technical Digest (Optica Publishing Group, 2012), paper PDP5A.6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Single Molecule Fluorescence Approaches Shed Light on Intracellular RNAs (2014)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTSingle Molecule Fluorescence Approaches Shed Light on Intracellular RNAsSethuramasundaram Pitchiaya†‡, Laurie A. Heinicke‡, Thomas C. Custer§, and Nils G. Walter*†‡View Author Information† ‡ †Single Molecule Analysis in Real-Time (SMART) Center, ‡Single Molecule Analysis Group, Department of Chemistry, and §Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109-1055, United States*Tel.: (734) 615-2060. E-mail: [email protected]Cite this: Chem. Rev. 2014, 114, 6, 3224–3265Publication Date (Web):January 8, 2014Publication History Received9 September 2013Published online8 January 2014Published inissue 26 March 2014https://pubs.acs.org/doi/10.1021/cr400496qhttps://doi.org/10.1021/cr400496qreview-articleACS PublicationsCopyright © 2014 American Chemical SocietyRequest reuse permissionsArticle Views4973Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Fluorescence,Fluorophores,Genetics,Molecules,Probes Get e-Alerts
Abstract 13400: STAT3 ASO-Loaded Microbubbles With Pulsed Ultrasound for Enhanced Therapeutic Effect in Head and Neck Tumors (2021)

Introduction: Signal transducer and activator of transcription 3 ( STAT3 ) is an oncogenic transcription factor implicated in carcinogenesis, tumor progression, and drug resistance in many cancers, including head and neck squamous cell carcinoma ( HNSCC ). STAT3 antisense oligonucleotide ( ASO ) specifically targeting the nucleotide sequence of STAT3 has therapeutic promise, but effective delivery remains challenging. We developed microbubble ( MB ) delivery vehicles loaded with STAT3 ASO and hypothesized that compared to intravenous ( i.v. ) delivery, ultrasound-targeted microbubble cavitation ( UTMC )-mediated ASO delivery confers superior tumor growth inhibition. Methods: Lipid MBs loaded with STAT3 ASO (S3MB) or mutant ASO (Mut-MB) were prepared. First, murine squamous carcinoma cells (SCC-7) in contact with MBs were exposed to pulsed ultrasound (1 MHz, 0.5 MPa, 100 μs pulse duration, 1 ms pulse interval) for 10 sec to establish efficacy with respect to cytotoxicity, apoptosis, and gene knockdown. Thereafter, the anti-tumor effect of 3 treatments with STAT3 ASO (10 μg) delivered i.v. or via UTMC x 15 min ( f= 1MHz, 0.7MPa, 100 cycles x 5 every 2 sec) was compared in vivo in a murine SCC-7 xenograft model followed up to 17 days. Results: S3MB + UTMC conferred more cytoxocitiy, apoptosis, and downregulation of transcripts for STAT3 and its target genes (Bcl-xL and Cyclin D1) compared to Mut-MB + UTMC in vitro (p&lt;0.05). In tumor bearing mice, compared to i.v. STAT3 ASO (n=8), Mut-MB+UTMC (n=5) or no treatment (n=8), S3MB + UTMC (n=9) significantly attenuated tumor burden, prolonged doubling time, and improved survival (p&lt;0.05). While i.v. STAT3 ASO had no effect on tumor expression of STAT3, Bcl-x, and cyclin D1 at the transcript and protein levels, its delivery via UTMC significantly reduced tumor expression of these genes (p&lt;0.01). Conclusion: At a dose of 10 μg, STAT3 ASO significantly inhibited murine HNSCC tumor growth and downregulated STAT3 and its target genes when delivered via UTMC, compared with intravenous administration alone. Our platform offers a promising imaged-guided, targeted delivery strategy for nucleotide-based therapeutics in cancer applications.
Long-Term Followup of the Miller-Galante Total Knee Replacement (2001)

One hundred seventy-two consecutive cemented Miller-Galante-I total knee arthroplasties in 155 patients were compared with 109 consecutive cemented Miller-Galante-II total knee arthroplasties in 92 patients. The average followup was 11 years (range, 8-15 years) and 9 years (range, 8-10 years), respectively. Of the 172 Miller-Galante-I arthroplasties, there have been 21 revisions; 15 patellar revisions; two included femoral revisions attributable to abrasion. Six additional well-fixed femoral and tibial components were revised: two for early instability, one for pain, one for periprosthetic fracture, and two for infection. No component had aseptic loosening or osteolysis. Using revision or loosening of any components as the end point, the Kaplan-Meier 10-year survivorship was 84.1% +/- 4.1%. Of the 109 Miller-Galante-II arthroplasties, there have been no component revisions, no aseptic loosening, and no osteolysis. Using revision or loosening of any components as the end point, the Kaplan-Meier 10-year survivorship was 100%. The Miller-Galante knee systems showed excellent fixation with no loosening and no osteolysis at as many as 15 years. Additionally, there have been no component revisions for late instability at as many as 15 years. Finally, the high prevalence of patellofemoral complications with the Miller-Galante-I design has been obviated with the Miller-Galante-II design.
Wear of a Total Ankle Replacement (2022)

Osteoarthritis of the ankle is a disease that affects 2% of the population in the United States. The most common current treatment entails fusing the ankle. This leads to complications such as reduced range of motion, infection, non-union, and deterioration of adjacent joints. Total joint replacement is a successful treatment for osteoarthritis of the hip and the knee and recently, interest in using this procedure in the ankle has occurred. A review of the currently available total ankle replacements was completed finding a promising trend in the survivorship of the devices. It was also found that these devices still have complications of loosening and subsidence. A new total ankle replacement is described here. The kinematics and loading in the ankle is also discussed as it applies to the development of a wear test for this new device. Subsequently the wear rate, wear debris, and contact stress are compared to those reported in the literature. The wear test consisted of using both gravimetric and volumetric techniques. This new total ankle replacement was found to have a wear rate that is lower than existing ankle implants and similar to that found in other total joint replacements.
Analysis of Massive MIMO and Base Station Cooperation in an Indoor\n Scenario (2018)

The performance of centralized and distributed massive MIMO deployments are\nanalyzed for indoor office scenarios. The distributed deployments use one of\nthe following precoding methods: (1) local precoding with local channel state\ninformation (CSI) to the user equipments (UEs) that it serves; (2) large-scale\nMIMO with local CSI to all UEs in the network; (3) network MIMO with global\nCSI. For the distributed deployments (2) and (3), it is shown that using twice\nas many base station antennas as data streams provides many of the massive MIMO\nbenefits in terms of spectral efficiency and fairness. This is in contrast to\nthe centralized deployment and the distributed deployment (1) where more\nantennas are needed. Two of the main conclusions are that distributing base\nstations helps to overcome wall penetration loss; however, a backhaul is\nrequired to mitigate inter-cell interference. The effect of estimation errors\non the performance is also quantified.\n
First-in-human phaseⅠstudy of JPH203 in patients with advanced solid tumors. (2018)

419 Background: Uptake of amino acids is essential for cancer growth. L-type amino acid transporter-1 (LAT-1) is overexpressed in various cancers, and uptake of LAT-1 substrate amino acids is known to have a critical role in cancer growth. JPH203 is a novel, selective, LAT-1 inhibitor. A first-in-human phase I study of JPH203 was designed to determine the safety, maximum-tolerated dose (MTD) and recommended dose. This study included evaluation of the anti-tumor effect, pharmacokinetics, and pharmacodynamics of JPH203 and analyzed plasma free amino acids. Methods: JPH203 was administered intravenously for 7 days followed by 21 days’ rest at planned doses ranging from 12 to 110 mg/m 2 in patients with advanced solid tumors refractory to standard therapy. Before starting this schedule, we confirmed safety of a single dose of JPH203. Dose-limiting toxicity was evaluated during the first cycle, using a 3+3 design. Results: 17 patients were enrolled from January 2015 to August 2016. One patient was discontinued after a single dose of JPH203 because of tumor progression. Dosage was escalated up to 85 mg/m 2 . Grade 3 liver dysfunction occurred in 1 of 6 patients at 60 mg/m 2 and in the first patient at 85 mg/m 2 . Therefore, it was determined that MTD was 60 mg/m 2 . Common treatment-related adverse events were increased ALT/AST, malaise, nausea, hypertension and fever of Grade 1 or 2. Partial response was achieved in a patient with biliary tract cancer (BTC) who continued JPH203 for two years without progression. Disease control (PR+SD) was observed in 3 of 5 patients with BTC and 2 of 6 with colorectal cancer. LAT-1 substrate amino acids and branched chain amino acids including LAT-1 substrate amino acids were higher in patients with BTC than in those with other cancers. All patients with disease control had a body mass index more than the median of 20.5 kg/m 2 . In exploratory analysis, longer survival was achieved in patients with high inhibition of uptake of LAT-1 substrate amino acids, compared with patients with low inhibition of uptake. Conclusions: JPH203 was well tolerated, resulting in promise against BTC. This phase I study suggested that LAT-1 could be targeted in treatment for advanced BTC, because LAT-1 substrate amino acids in plasma tended to remain high. Clinical trial information: UMIN000016546.
XeCl excimer laser with high repetition rate and low divergence beam (1996)

Configuration and performance of a high repetition rate XeCl excimer laser are reported. The laser maximum output energy is 415 mJ. Maximum average power is 35 W at repetition rate of 110 Hz. When unstable resonator optics are adopted on the laser. Beam divergence are improved about 10 times but expense of output energy in 30&percnt;.
Ablation Dynamics of Silicon by Femtosecond Laser and the Role of Early Plasma (2013)

In this paper, the femtosecond laser ablation of silicon is investigated by a two-dimensional hydrodynamic model. The ablation depth of the silicon wafer ablated in air at different laser intensities is calculated, and the corresponding experimental measurements are carried out for validation. Two different ablation regimes have been identified by varying the laser fluence. While two-photon absorption dominates in the low fluence regime (&lt; 2 J/cm2), electron heat diffusion is a major energy transport mechanism at higher laser fluences (&gt; 2 J/cm2). The ablation efficiency first increases with the laser fluence, and reaches the peak value at the laser fluence around 8 J/cm2. It starts to drop when the laser fluence further increases, because of the early plasma absorption of the laser beam energy.