gebhart/patrepeval huggingface dataset:
Abstract #5608: Synthetic lethal interaction between oncogenic KRAS dependency and suppression of STK33 in human cancer cells (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

Activating KRAS mutations are among the most common pathogenetic events in a broad spectrum of hematologic malignancies and epithelial tumors. However, oncogenic KRAS has thus far not proven to be a tractable target for therapeutic intervention. An alternative to direct targeting of known oncogenes is to perform \#8220;synthetic lethality\#8221; screens to identify genes that are selectively required for cell viability in the context of specific cancer-causing mutations. Using this approach, we have discovered a synthetic lethal interaction between mutant KRAS, the most frequently mutated oncogene in human cancer, and inactivation of the gene encoding the STK33 serine/threonine protein kinase. To identify genes that are essential for cell viability in the context of mutant KRAS, we performed high-throughput loss-of-function RNA interference (RNAi) screens in eight human cancer cell lines (mutant KRAS, n=4; wildtype KRAS, n=4), representing five different tumor types (acute myeloid leukemia, colon cancer, breast cancer, prostate cancer, glioblastoma), as well as normal human fibroblasts and mammary epithelial cells. We screened each cell line with a subset of the short hairpin RNA (shRNA) library developed by the RNAi Consortium that consists of 5,024 individual shRNA constructs targeting 1,011 human genes, including the majority of known and putative protein kinase genes and a selection of protein phosphatase genes and known cancer-related genes. In these cell lines, suppression of STK33 preferentially inhibited the viability and proliferation of cells that were dependent on mutant KRAS. The differential requirement for STK33 based on oncogenic KRAS dependency was confirmed in 17 additional cell lines using in vitro transformation assays and human tumor xenograft models. Biochemical analyses support the hypothesis that STK33 promotes cell growth and survival in a kinase activity-dependent manner by regulating the activity of S6K1 selectively in mutant KRAS-dependent cells. Notably, molecular genetic characterization of cancer cell lines and analysis of patient-derived genomic data sets indicated that STK33 is not frequently mutated or overexpressed in human tumors. These observations identify STK33 as a potential target for the treatment of mutant KRAS-driven cancers that may have a broad therapeutic index in normal versus malignant cells, and illustrate the potential of RNAi for discovering critical functional dependencies created by oncogenic mutations that cannot be identified using other genomic technologies.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5608.
ChemInform Abstract: Regioselective Functionalization of the Methylene Group Adjacent to Cyclopropyl Sulfide via Mercury(II)‐Mediated Regioselective Ring‐ Opening Reaction. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Figures 1-5. from TTPAL Promotes Colorectal Tumorigenesis by Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling (2023)

&lt;p&gt;Supplementary Figure 1. Screening of TTPAL by whole genome sequencing and TTPAL amplification validation in CRC. Supplementary Figure 2. TTPAL effects on signaling pathway. Supplementary Figure 3. TRIP6 was highly expressed in CRC. Supplementary Figure 4. TRIP6 showed oncogenic function in CRC. Supplementary Figure 5. MAGI1 showed tumor suppressor function in CRC.&lt;/p&gt;
Total Elbow Arthroplasty in the Treatment of Posttraumatic Conditions of the Elbow (2000)

Posttraumatic arthritis, arthritis secondary to instability, and nonunion or malunion about the elbow may be treated by various methods. Recommended first-line treatment in the younger, more active patient population is nonprosthetic techniques. Total elbow arthroplasty should be considered primarily as a salvage procedure for these patients. Careful patient selection will determine whether total elbow arthroplasty is an acceptable choice, despite its inherent risks and complications. Prosthetic replacement is more applicable for patients with low physical demands who are older than 60 years of age with pain, stiffness, and/or instability of the elbow who will more likely be able to comply with postoperative rehabilitation and strict activity restrictions. Previous incisions, gross instability, periarticular fibrosis with ulnar nerve encasement, loss of bone and/or soft tissue, and previous infections represent obstacles for prosthetic reconstruction in these patients. The use of unlinked total elbow designs require good bone stock with little deformity and stable capsuloligamentous support, which uncommonly is found in elbows after trauma. Linked semiconstrained prostheses have been used most frequently with good short-term results reported in the literature. Reported failure rates after longer followup have led to a search for improvements in prosthetic design, cementing techniques, and better patient selection.
An algorithm for the design of multiplierless approximately linear-phase lattice-wave digital filters (2002)

This paper describes an efficient algorithm for the design of multiplierless approximately linear-phase lattice wave digital (LWD) filters (parallel connection of two all-pass filters). The coefficient optimization is performed in two basic steps. First, a nonlinear optimization algorithm is used for determining a parameter space of the finite-precision coefficients including the feasible space where the filter meets the given amplitude and phase specifications. The second step involves finding the filter parameters in this space such that the resulting filter meets the given criteria with the simplest coefficient representation forms. The proposed algorithm guarantees that the optimum multiplierless finite-wordlength solution can be found. This is illustrated by means of an example.
Retinal Image Matching Using Hierarchical Vascular Features (2011)

We propose a method for retinal image matching that can be used in image matching for person identification or patient longitudinal study. Vascular invariant features are extracted from the retinal image, and a feature vector is constructed for each of the vessel segments in the retinal blood vessels. The feature vectors are represented in a tree structure with maintaining the vessel segments actual hierarchical positions. Using these feature vectors, corresponding images are matched. The method identifies the same vessel in the corresponding images for comparing the desired feature(s). Initial results are encouraging and demonstrate that the proposed method is suitable for image matching and patient longitudinal study.
Monolithic perovskite/silicon-heterojunction tandem solar cells processed at low temperature (2015)

We present a monolithic perovskite/silicon tandem cell enabling a high Voc and a stabilized power output of 18%.
Antimicrobial silica particles loaded with quaternary ammonium polyethyleneimine network (2014)

Silica particles functionalized with quaternary ammonium groups were prepared by interpenetrating polyethylenimine (PEI) into silica particles and crosslinking with diiodopentane, followed by octyliodide alkylation and methyliodide quaternarization (S‐QA‐PEI). The synthesized S‐QA‐PEI particles were identified with a slight particle size increase of 2–3 µm. Different ratios of PEI:silica particles were prepared and analyzed. While silica particles are negatively charged, −16.7 ± 5.11 mV, the prepared S‐QA‐PEI particles are positively charged, +50–60 mV. These particles were embedded in poly(ethylene vinyl acetate) and poly(ethylene methacrylic acid) coatings which exhibited strong antibacterial activity. Copyright © 2014 John Wiley &amp; Sons, Ltd.
Efficient and scalable statistics gathering for large databases in Oracle 11g (2008)

Large tables are often decomposed into smaller pieces called partitions in order to improve query performance and ease the data management. Query optimizers rely on both the statistics of the entire table and the statistics of the individual partitions to select a good execution plan for a SQL statement. In Oracle 10g, we scan the entire table twice, one pass for gathering the table level statistics and the other pass for gathering the partition level statistics. A consequence of this gathering method is that, when the data in some partitions change, not only do we need to scan the changed partitions to gather the partition level statistics, but also we have to scan the entire table again to gather the table level statistics. Oracle 11g adopts a one-pass distinct sampling based method which can accurately derive the table level statistics from the partition level statistics. When data change, Oracle only re-gathers the statistics for the changed partitions and then derives the table level statistics without touching the unchanged partitions. To the best of our knowledge, although the one-pass distinct sampling has been researched in academia for some years, Oracle is the first commercial database that implements the technique. We have performed extensive experiments on both benchmark data and real customer data. Our experiments illustrate the this new method is highly accurate and has significantly better performance than the old method used in Oracle 10g.
Kinase-driven metabolic signalling as a predictor of response to carboplatin–paclitaxel adjuvant treatment in advanced ovarian cancers (2017)

If validated in a larger cohort of patients, the decreased AMPK-AKT-mTOR activation and phosphorylation of FOXO1 T24/FOXO3 T32 may help identify carboplatin-paclitaxel-resistant EOC patients.
The analytical pyrolysis of carbohydrates. 2—differentiation of homopolyhexoses according to their linkage type, by pyrolysis-mass spectrometry and pyrolysis-gas chromatography/mass spectrometry (1984)

Curiepoint pyrolysis (Py)-mass spectrometry (14 eV electron impact) in various modes of operation and Curiepoint pyrolysis-gas chromatograpy/mass spectrometry (Py-GC/MS) afforded discrimination between homopolyhexoses of different glycosidic linkage type and configuration: (1 → 2)-β-, (1 → 3)-β-, (1 → 4)-α-, (1 → 4)-β-, (1 → 6)-α, (1 → 6)-β-glucan and (1 → 2)-α-mannan. Pyrolysis-mass spectrometry in multichannel averaging mode, combined with discriminant analysis data processing, revealed significant discrimination between all polyhexoses, except for the (1→6) linked polymers. By using preheated telescopic glass tube sample holders, additional specificity of the pyrolysis-mass spectral fingerprint for the (1 → 3) linked carbohydrate was obtained. Pyrolysis-mass spectrometry in time-resolved mode yielded ion profiles, especially characteristic for the (1 → 3)-β-glucan. Py-GC/MS was an additional discriminating dimension (retention time), providing structural information about the pyrolysate constituents, in particular concerning the anhydrohexoses.
Efficiency Measurements of an Annular Nozzle Guide Vane Cascade With Different Film Cooling Geometries (1998)

This paper further extends the research reported by Day et al. (1997), which reported aerodynamic efficiency measurements on an annular cascade of engine representative transonic nozzle guide vanes with extensive film cooling. This work compares the measured aerodynamic efficiencies of blades with 14 rows of cylindrical cooling holes with a new geometry in which 8 of the rows have been replaced by holes having a fan-shaped exit geometry. The effects of adding trailing edge slot ejection are also presented. By selectively blocking rows of holes, the cumulative effect on the mid-span efficiency of adding rows of cooling holes has also been determined. A dense foreign gas (SF6/Ar mixture) is used to simulate engine representative coolant-to-mainstream density ratios, momentum ratios and blowing rates under ambient temperature conditions. The flowfield measurements have been obtained using a four-hole pyramid probe in a short duration blowdown facility which correctly models engine Reynolds and Mach numbers, as well as the inlet turbulence intensity. Experimental results are presented as area traverse maps (total pressure, isentropic Mach number and flow angles), from which the incremental changes in efficiency due to film cooling have been calculated. The effects of different assumptions for the coolant total pressure are shown. Experimental data agrees reasonably well with loss predictions using a Hartsel model.
Wind turbine blockset in Matlab/simulink. General overview and description of the models (2004)

This report presents a new developed Matlab/Simulink Toolbox for wind turbine applications. This toolbox has been developed during the research project 'Simulation Platform to model, optimize and design wind turbines' and it has been used as a general developer tool for other three simulation tools: Saber, DIgSILENT, HAWC. The report provides first a quick overview over Matlab issues and then explains the structure of the developed toolbox. The attention in the report is mainly drawn to the description of the most important mathematical models, which have been developed in the Toolbox. Then, some simulation results using the developed models are shown. Finally, some general conclusions regarding this new developed Toolbox as well as some directions for future work are made. (au)
Influence of a Driver Support System on Situation Awareness and Information Processing in Response to Lead Vehicle Braking (2004)

Situation Awareness (SA) is critical to safe driving in a dynamic traffic environment. SA is predicated on the timely sampling of information in the driving environment. Distraction from secondary tasks can interrupt this sampling resulting in increased traffic conflicts and crashes. It is hypothesized that SA may be improved if sampling is augmented with (redundant) non-visual feedback about relevant information in the driving scene. The current study examined a Driver Support System (DSS) based on continuous haptic feedback communicated through the gas pedal. This system was evaluated in a driving simulator with participants distracted by a secondary task utilizing the CD player. The results indicate that this DSS improved reaction time, response time, and response appropriateness (safety margin) despite an apparent increase in the transition period between pedals. Various mechanisms to explain these effects are posited.
Analysis of College Dropouts—Some Manifest and Covert Reasons (1968)

The importance of identifying the real reasons why students withdraw from colleges and universities is substantiated by citing studies that have been underway at California State College at Long Beach. One very important aspect of these studies indicates that the reasons given by the withdrawing students are not, many times, the true reasons as seen by trained counselors.
Image segmentation for large-scale subcategory flower recognition (2013)

We propose a segmentation algorithm for the purposes of large-scale flower species recognition. Our approach is based on identifying potential object regions at the time of detection. We then apply a Laplacian-based segmentation, which is guided by these initially detected regions. More specifically, we show that 1) recognizing parts of the potential object helps the segmentation and makes it more robust to variabilities in both the background and the object appearances, 2) segmenting the object of interest at test time is beneficial for the subsequent recognition. Here we consider a large-scale dataset containing 578 flower species and 250,000 images. This dataset is developed by our team for the purposes of providing a flower recognition application for general use and is the largest in its scale and scope. We tested the proposed segmentation algorithm on the well-known 102 Oxford flowers benchmark [11] and on the new challenging large-scale 578 flower dataset, that we have collected. We observed about 4% improvements in the recognition performance on both datasets compared to the baseline. The algorithm also improves all other known results on the Oxford 102 flower benchmark dataset. Furthermore, our method is both simpler and faster than other related approaches, e.g. [3, 14], and can be potentially applicable to other subcategory recognition datasets.
What Hashes Make RSA-OAEP Secure? (2006)

Firstly, we demonstrate a pathological hash function choice that makes RSA-OAEP insecure. This shows that at least some security property is necessary for the hash functions used in RSA-OAEP. Nevertheless, we conjecture that only some very minimal security properties of the hash functions are actually necessary for the security of RSA-OAEP. Secondly, we consider certain types of reductions that could be used to prove the OW-CPA (i.e., the bare minimum) security of RSA-OAEP. We apply metareductions that show if such reductions existed, then RSA-OAEP would be OW-CCA2 insecure, or even worse, that the RSA problem would solvable. Therefore, it seems unlikely that such reductions could exist. Indeed, no such reductions proving the OW-CCA2 security of RSA-OAEP exist.
Backgrounds as information carriers for printed documents (2002)

This paper presents a method of embedding and recovery of a large amount of data on printed documents. The proposed method is characterized by the following points: (1) As the medium for recording the data, backgrounds (white space) of pages are utilized. Since white space is dominant in ordinary pages, this enables us to record a large amount of data. (2) As the representation of data, an arbitrary figure (such as a logo mark of a company) is stippled to obtain a set of points, each of which is superimposed on a page image. This allows us to prevent the appearance of a page from deteriorating, since stippled figures play a role of background patterns on printed documents. The experimental results show that the method is capable of both recording 7.8KB of data and reading the embedded data with the accuracy of 99%.
Inhibition of Advanced Glycation End-Products by Tamarindus indica and Mitragyna inermis Extracts and Effects on Human Hepatocyte and Fibroblast Viability (2023)

<i>Tamarindus indica</i> and <i>Mitragyna inermis</i> are widely used by herbalists to cure diabetes mellitus. The aim of this study is to investigate the inhibitory potential of aqueous and various organic solvent fractions from both plants and some isolated compounds against advanced glycation end-products (AGEs). For this purpose, an in vitro BSA-fructose glycation model was used to evaluate the inhibition of AGE formation. Furthermore, the effects of the fractions on mouse fibroblast (NIH-3T3) and human hepatocyte (HepG2) survival were evaluated. The leaf, stem, and root fractions of both plants exhibited significant inhibition of AGEs formation. The IC<sub>50</sub> values appeared to be less than 250 µg/mL; however, all fractions presented no adverse effects on NIH-3T3 up to 500 µg/mL. Otherwise, our phytochemical investigation afforded the isolation of a secoiridoid from the <i>Mitragyna</i> genus named secoiridoid glucoside sweroside (<b>1</b>), along with three known quinovic acid glycosides: quinovic acid-3<i>β</i>-<i>O</i>-<i>β</i>-d-glucopyranoside (<b>2</b>), quinovic acid-3-<i>O</i>-<i>β</i>-d-6-deoxy-glucopyranoside, 28-<i>O</i>-<i>β</i>-d-glucopyranosyl ester (<b>3</b>), and quinovic acid 3-<i>O</i>-<i>α</i>-l-rhamnopyranosyl-(4→1)-<i>β</i>-d-glucopyranoside (<b>4</b>). In particular, <b>1</b>-<b>3</b> are compounds which have not previously been described in <i>Mitragyna inermis</i> roots. However, the isolated compounds did not exhibit AGE inhibitory activity. Further investigation on these potent antiglycation fractions may allow for the isolation of new antidiabetic drug candidates.
Path and significance of heart vector migration during QRS and ST-T complexes of ectopic beats in isolated perfused rabbit hearts. (1977)

&lt;p&gt;Continuous drying processes using supercritical CO&lt;sub&gt;2&lt;/sub&gt; (scCO&lt;sub&gt;2&lt;/sub&gt;) as a water extraction agent require 24/7 operational dehydration units for scCO&lt;sub&gt;2&lt;/sub&gt; regeneration. Dehydration units using dense polymeric membranes are considered a cost effective, sustainable alternative to the current zeolite-based units. The focus of previous studies on the membrane-based dehydration of scCO&lt;sub&gt;2&lt;/sub&gt; was always on the membrane itself whereas boundary layer effects, e.g., concentration polarization, were not taken into account. To quantify the boundary layer effects, simulations were performed using three different membrane materials: SPEEK, Nafion&lt;sup&gt;®&lt;/sup&gt; 117, and PEBAX&lt;sup&gt;®&lt;/sup&gt; 1074. Process conditions during the simulations ranged from 8.0 to 18.0 MPa and 40 to 100 °C. Even though the three types of membranes examined differ in their H&lt;sub&gt;2&lt;/sub&gt;O permeability and H&lt;sub&gt;2&lt;/sub&gt;O over CO&lt;sub&gt;2&lt;/sub&gt; selectivity, in all cases 80% of the total mass-transfer resistance can be assigned to concentration polarization effects, making it the dominant parameter for water transport. Despite high but differing intrinsic water permeabilities of all three membranes materials, the H&lt;sub&gt;2&lt;/sub&gt;O transport, thus H&lt;sub&gt;2&lt;/sub&gt;O flux through the membrane is significantly reduced by concentration polarization down to similar levels. This makes it necessary to use larger membrane areas, that result in higher CO&lt;sub&gt;2&lt;/sub&gt; fluxes. As a consequence, material selection is predominantly based on the ability to reject CO&lt;sub&gt;2&lt;/sub&gt;. Optimization of process conditions other than membrane material is briefly discussed.&lt;/p&gt;
Immunosuppression with aerosolized cyclosporine for prevention of lung rejection in a rat model (1991)

The efficacy of local delivery of aerosol cyclosporine (CsA) for prevention of lung rejection was compared with the intramuscular route (IM) in a fully allogeneic rat model (BN/LEW) of lung transplantation (LTx). Control rats (group 1, n = 6) received no CsA after LTx. Rats in group 2 (n = 10) received 4 doses of CsA in olive oil (25 mg/kg) intramuscularly starting on postoperative day (POD) 0. Group 3 (n = 9) was treated with aerosolized CsA for 3 h/day for 7 days starting on POD 0. All animals were sacrificed on POD 6. Transplanted lungs were graded histologically in a blind manner on a 0-4 scale. Control animals all showed grade 4 rejection. i.m. CsA therapy reduced lung rejection with a rejection grade of 1.8 +/- 0.35 (mean +/- SD) but was associated with a 50% incidence of pneumonia. Aerosol CsA provided better control of rejection with a rejection grade of 1.2 +/- 0.4 (group 3 vs. group 2: P less than 0.05 Wilcoxon) and none of these animals had penumonia. Trough blood levels of CsA were significantly lower in the group treated with aerosolized CsA when compared with the IM group (P less than 0.05). Therefore we conclude that: (1) aerosol CsA is effective in preventing lung allograft rejection following lung transplantation in rats, and (2) local delivery of aerosol CsA is superior to the i.m. route because better control of rejection is achieved with a lower systemic delivery of CsA.
iOCT-assisted macular hole surgery: outcomes and utility from the DISCOVER study (2020)

This study suggests that iOCT may have important utility in MH surgery, including impacting surgical decision making. iOCT-assisted MH surgery resulted in significant improvement in VA and high single-surgery success rate.