gebhart/patrepeval huggingface dataset:
Synthesis and cytostatic activities of didemnin derivatives* (1999)

The highly cytostatic didemnins contain a 23-membered cyclopeptolide with a side chain attached to the backbone through the amine group of threonine. Thirty-six derivatives varying the side chain were prepared, but only compounds with D-MeLeu attached to threonine show remarkable biological activities. To protect the macrocycle from degradation by lipases the two ester bonds were replaced successively by amide bonds. Although these variations have a major effect on the conformation and rigidity of the ring, the compound which contains exclusively amide bonds is highly active, equivalent to acetyl-didemnin A.
ChemInform Abstract: Novel Intramolecular Michael Addition of Organomercury Halides Mediated by a Lewis Acid and Halide Anion. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Single Dose of Any of Four Different Live Attenuated Tetravalent Dengue Vaccines Is Safe and Immunogenic in Flavivirus-naive Adults: A Randomized, Double-blind Clinical Trial (2013)

TV003 induced a trivalent or greater antibody response in 90% of flavivirus-naive vaccinees and is a promising candidate for the prevention of dengue. Race was identified as a factor influencing the infectivity of the LATV viruses, reflecting observations of the effect of race on disease severity in natural dengue infection.
Complications: early and late after ablation (2015)

This chapter discusses the complications of atrial fibrillation (AF) ablation and possible strategies to reduce their incidence and limiting harm to patients. Complications of AF ablation may range from local to life-threatening conditions. Complications of AF ablation can be classified as early, when they occur during the procedure itself and late if they occur within 30 days thereafter. According to the worldwide AF ablation survey, cardiac tamponade was found to be the most common fatal complication leading to cardiac arrest during or after AF ablation. Late complications of AF catheter ablation should be considered as any adverse event, which usually happens after the procedure, occurring within a temporal frame of 30 days or is clearly related to the procedure. Patient's safety is paramount and is the most important rule electrophysiologists (especially if young or inexperienced) need to respect in the context of AF ablation.
Circulating miRNA panels for specific and early detection in bladder cancer (2018)

Bladder cancer is the 9th leading cause of cancer death worldwide. The major problem in bladder cancer is primarily the high recurrence rate after drug treatment and resection. Although conventional screening methods, such as cystoscopy, urinary cytology and ultrasound sonography, have become widely used in clinical settings, the diagnostic performance of these modalities is unsatisfactory due to low accuracy or high invasiveness. Because circulating micro RNA (miRNA) profiles have recently been reported as an attractive tool for liquid biopsy in cancer screening, here, we performed global miRNA profiling of 392 serum samples of bladder cancer patients with 100 non-cancer samples and 480 samples of other types of cancer as controls. We randomly classified the bladder cancer and control samples into 2 cohorts, a training set (N = 486) and a validation set (N = 486). By comparing both controls, we identified specific miRNA, such as miR-6087, for diagnosing bladder cancer in the training and validation sets. Furthermore, we found that a combination of 7 miRNA (7-miRNA panel: miR-6087, miR-6724-5p, miR-3960, miR-1343-5p, miR-1185-1-3p, miR-6831-5p and miR-4695-5p) could discriminate bladder cancer from non-cancer and other types of tumors with the highest accuracy (AUC: .97; sensitivity: 95%; specificity: 87%). The diagnostic accuracy was high, regardless of the stage and grade of bladder cancer. Our data demonstrated that the 7-miRNA panel could be a biomarker for the specific and early detection of bladder cancer.
AncesTree: an interactive immunoglobulin lineage tree visualizer (2020)

Abstract High-throughput sequencing of human immunoglobulin genes allows analysis of antibody repertoires and the reconstruction of clonal lineage evolution. Phylip, an algorithm that has been originally developed for applications in ecology and macroevolution, can also be used for the phylogenic reconstruction of antibodies maturation pathway. The study of antibodies (Abs) affinity maturation is of specific interest to understand the generation of Abs with high affinity or broadly neutralizing activities. Phylogenic analysis enables the identification of the key somatic mutations required to achieve optimal antigen binding. To complement Phylip algorithm, we developed AncesTree, a graphic user interface (GUI) that aims to give researchers the opportunity to interactively explore antibodies clonal evolution. AncesTree displays interactive immunoglobulins (Ig) phylogenic tree, Ig related mutations and sequence alignments using additional information coming from specialized antibody tools (such as IMGT ® ). The GUI is a Java standalone application allowing interaction with Ig-tree that can run under Windows, Linux and Mac OS.
Supplementary Figures 1-4 from Lin<sup>−</sup>Sca-1<sup>+</sup>CD49f<sup>high</sup> Stem/Progenitors Are Tumor-Initiating Cells in the <i>Pten</i>-Null Prostate Cancer Model (2023)

Supplementary Figures 1-4 from Lin&lt;sup&gt;−&lt;/sup&gt;Sca-1&lt;sup&gt;+&lt;/sup&gt;CD49f&lt;sup&gt;high&lt;/sup&gt; Stem/Progenitors Are Tumor-Initiating Cells in the &lt;i&gt;Pten&lt;/i&gt;-Null Prostate Cancer Model
Pulmonary Angiography for the Diagnosis of Thromboembolic Events in the Non-Human Primate (2004)

Minimally invasive pulmonary angiography is a safe, reproducible, and inexpensive method to assess possible thromboembolic events in the non-human primate. This method may allow for the longitudinal assessment of non-human primates given novel agents that may promote thromboembolism.
Repetition rescues regenerative reserve (2015)

This editorial refers to ‘Improved outcome with repeated intracoronary injection of bone marrow-derived cells within a registry: rationale for the randomized outcome trial REPEAT’[†][1], by B. Assmus et al ., on page 1659. 

Myocardial infarction (MI) is a leading cause of global morbidity, with 1-year mortality rates nearing 20%, despite aggressive intervention and dwindling door-to-balloon times.1,2 In the reperfusion era, pharmacotherapy utilized as an adjunct to percutaneous coronary intervention (PCI) has not proven to impact mortality.3 In fact, PCI-associated acute survival has created a counter-prevalence in the incidence of chronic heart failure. Accordingly, >35% of all heart failure cases are now ascribed to previous MI.4 Aggravated myocardial vulnerability has been predicated, in part, on the age of the patient—a pre-eminent predictor of poor outcomes. The risk of compromised survivorship, in both men and women, for first time and recurrent MI is dramatically accentuated in the sixth decade of life and beyond.5 Young hearts harbour a capacity for homeostatic renewal, reported at ∼1% of heart mass per year at least for the first five decades of life. However, the propensity to rejuvenate declines rapidly with advanced age.6

Regenerative reserve is a reflection of the ability to maintain homeostasis in the setting of insult through self-reparative mechanisms. Breakdown of this fundamental safeguard, as evidenced in ageing, increases the risk for death. Declining post-MI survivorship trends over time provide in part a surrogate measure of regenerative reserve dynamics in populations of different ages ( Figure 1 ). Using this evolving concept, the regenerative reserve can be extrapolated for survivors of acute MI stratified by age groups ( Figure 1A ). For the …

 [1]: #fn-2
Combination therapy of hypertension in the elderly: a subgroup analysis of the Combination of OLMesartan and a calcium channel blocker or diuretic in Japanese elderly hypertensive patients trial (2014)

Combination of OLMesartan and a calcium channel blocker or a diuretic in Japanese elderly hypertensive patients (COLM) trial demonstrated that olmesartan combinations with a CCB or diuretic have similar effects on reducing cardiovascular risk in elderly hypertensive patients. However, the safety profiles suggest that olmesartan combined with CCB may be preferable to olmesartan combined with diuretic. In this subgroup analysis, we further evaluated the effects and safety of these combinations in elderly (65-74 years old (y.o.)) and very elderly (75-84 y.o.) hypertensive patients. In the COLM trial, 5141 patients (2918 elderly and 2223 very elderly) were randomly assigned to receive olmesartan-based therapy with either CCB or diuretic. The hazard ratios and 95% confidence intervals, respectively, in the elderly age group and in the very elderly group were: 1.04 (0.72-1.50; olmesartan plus CCB vs. olmesartan plus diuretic, P = 0.85) and 0.71 (0.51-0.99, P = 0.045) for the primary composite end point, and 1.07 (0.67-1.72, P = 0.77) and 0.64 (0.42-0.98, P = 0.036) for the composite of hard end points. The hazard ratios for stroke (fatal and non-fatal) were 1.48 (0.88-2.48; olmesartan plus CCB vs. olmesartan plus diuretic, P = 0.13) and 0.63 (0.39-1.02, P = 0.059) (interaction-P = 0.019). Withdrawal rates from the trial, withdrawal due to serious adverse event and the incidence of any adverse event were higher in the olmesartan plus diuretic group than in the olmesartan plus CCB group in both age groups. In conclusion, angiotensin receptor blocker (ARB) and CCB combination may be preferable to an ARB and diuretic combination in the very elderly hypertensive patients for the reduction of cardiovascular risk, particularly for the reduction in stroke risk.
Hippo pathway dysregulation in gastric cancer: from Helicobacter pylori infection to tumor promotion and progression (2023)

The Hippo pathway plays a critical role for balancing proliferation and differentiation, thus regulating tissue homeostasis. The pathway acts through a kinase cascade whose final effectors are the Yes-associated protein (YAP) and its paralog transcriptional co‑activator with PDZ‑binding motif (TAZ). In response to a variety of upstream signals, YAP and TAZ activate a transcriptional program that modulates cellular proliferation, tissue repair after injury, stem cell fate decision, and cytoskeletal reorganization. Hippo pathway signaling is often dysregulated in gastric cancer and in Helicobacter pylori-induced infection, suggesting a putative role of its deregulation since the early stages of the disease. In this review, we summarize the architecture and regulation of the Hippo pathway and discuss how its dysregulation fuels the onset and progression of gastric cancer. In this setting, we also focus on the crosstalk between Hippo and other established oncogenic signaling pathways. Lastly, we provide insights into the therapeutic approaches targeting aberrant YAP/TAZ activation and discuss the related clinical perspectives and challenges.
Synthesis and properties of liquid crystalline aromatic copolyesters with lactide moieties (1999)

High molecular weight liquid crystalline copolyesters were obtained by copolycondensation of aromatic diols and diacyl chlorides with oligolactides. The molecular structure of these copolyesters was verified by NMR studies. The copolyesters form nematic melts, which can be frozen in into a nematic glass. Unexpectedly, a fibrillar structure was observed exclusively on the surface of solution cast films. In spite of a significant content of lactide moieties of the copolyesters their films and fibers are characterized by exceptional mechanical properties. Initial experiments indicated excellent biocompatibility based on cell seeding experiments and microscopic evidence.
Highly Efficient Monocationic Palladacycles of Chelating Diphosphines in C2H4/CO Copolymerization (2000)

Cationic palladacycles of the general formula [{o-C6H4(CH2)N(R)2Pd(P⌒P)}][X] (P⌒P = Ph2P(CH2)3PPh2, (PhCH2)2C(CH2PPh2)2; X = Cl, PF6, B(C6H5)4; R = H, CH3, CH2C6H5) and [{o-(CH2)C6H4P(o-Tol)2Pd(P⌒P)}][X] (P⌒P = Ph2P(CH2)3PPh2; X = Cl, PF6) have been prepared and structurally characterized in the former case (X-ray structure analysis for X = PF6, R = CH3). They are resistant to air and moisture, both in solution and the solid state, and represent one of the most active single-component catalyst systems for the perfectly alternating C2H4/CO copolymerization in aprotic solvents. Stoichiometric model reactions provide insight into the mechanism, suggesting that insertion of carbon monoxide into the carbon−palladium(II) bond initiates the catalytic cycle.
Modeling the space elevator - a project oriented approach for teaching experimental power electronics (2007)

The "Solar Climber", a model version of the space elevator, is a great project to introduce students to power electronics. In this project the students are faced with the elementary engineering problem of powering a vehicle (an electro-mechanical system) from a limited energy source such as a solar panel in this case. Apart from learning about and building a simple buck converter as their first power electronics system, they must also identify the interdependences between a limited energy source, energy conversion efficiency, weight and climbing speed. A buck converter is required to convert a solar panel's output to a voltage level suitable for the electric motors that drive the elevator towards "space". This paper describes the motivation, the model space elevator, the learning outcomes and the experiences from this project. Further practical solar power projects, the solar car and mains interface, are presented that have proven to be excellent projects for teaching experimental power electronics.
A user cooperative beamforming approach to PAPR reduction in MIMO-OFDM uplink (2016)

We consider a scheme for PAPR reduction based on user cooperation in a single-cell multi-user MIMO-OFDM uplink system. The idea is to utilize the unused space-frequency resources induced by collaborative beamforming to transmit dummy symbols, resulting in a transmit signal with reduced per-antenna peak powers. Traditionally collaborative beamforming has been used to acquire beamforming gain, i.e., extended cell coverage and improved rates, while our approach also in addition reduces the transmit signal PAPR of individual user antennas. The reduced PAPR enables the users to allocate more power to data transmission, resulting in a higher system sum-rate for a fixed peak transmit power budget while also relaxing the strict linearity requirements of the user equipment RF components. We also account for the power required to exchange data between cooperating users by utilizing a simple AWGN channel model between users. We formulate the PAPR minimization problem as a convex optimization problem that reduces the PAPR of a given time domain transmit signal provided there are subcarriers with no previous bit allocations, which is a valid assumption especially at mid- and low-SNR regimes.
Functionalization of substituted 2(1H)- and 4(1H)-pyridones. 4. Synthesis of substituted 6-(aminocarbonyl)-1,2-dihydro-2-oxo- and 1,4-dihydro-4-oxo-3-pyridinecarboxylic acids (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFunctionalization of substituted 2(1H)- and 4(1H)-pyridones. 4. Synthesis of substituted 6-(aminocarbonyl)-1,2-dihydro-2-oxo- and 1,4-dihydro-4-oxo-3-pyridinecarboxylic acidsJohn M. DomagalaCite this: J. Org. Chem. 1984, 49, 1, 126–130Publication Date (Print):January 1, 1984Publication History Published online1 May 2002Published inissue 1 January 1984https://pubs.acs.org/doi/10.1021/jo00175a026https://doi.org/10.1021/jo00175a026research-articleACS PublicationsRequest reuse permissionsArticle Views380Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An unusual mechanism of a palladium-catalyzed intramolecular carbametalation. A novel palladium-catalyzed rearrangement (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn unusual mechanism of a palladium-catalyzed intramolecular carbametalation. A novel palladium-catalyzed rearrangementBarry M. Trost and Gerald J. TanouryCite this: J. Am. Chem. Soc. 1988, 110, 5, 1636–1638Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/ja00213a054https://doi.org/10.1021/ja00213a054research-articleACS PublicationsRequest reuse permissionsArticle Views1631Altmetric-Citations187LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Design of a laser printer using a laser array and beam homogenizer (2000)

A novel technique for homogenizing the multitude of beams emanating from a laser diode array is described, as it related to use as an illumination system in a laser printer. This illumination system was required to efficiently transform the multiple beams from a laser array into a single line of uniform light, incident upon a spatial light modulator array, without a loss of brightness. The importance of the laser diode source properties, including both spatial coherence and source Lagrange, will be considered relative to their impact on the system design. The design of the beam shaping optics, including the beam combiner optics and the fly's eye integrator assembly, will also be discussed. The implementation of this illumination system in a laser printer employing a modulator array will be discussed, including issues of alignment, component properties, and the results obtained during system integration.
The Expanding Complexity of Estrogen Receptor Signaling in the Cardiovascular System (2016)

Estrogen has important effects on cardiovascular function including regulation of vascular function, blood pressure, endothelial relaxation, and the development of hypertrophy and cardioprotection. However, the mechanisms by which estrogen mediates these effects are still poorly understood. As detailed in this review, estrogen can regulate transcription by binding to 2 nuclear receptors, ERα and ERβ, which differentially regulate gene transcription. ERα and ERβ regulation of gene transcription is further modulated by tissue-specific coactivators and corepressors. Estrogen can bind to ERα and ERβ localized at the plasma membrane as well as G-protein-coupled estrogen receptor to initiate membrane delimited signaling, which enhances kinase signaling pathways that can have acute and long-term effects. The kinase signaling pathways can also mediate transcriptional changes and can synergize with the ER to regulate cell function. This review will summarize the beneficial effects of estrogen in protecting the cardiovascular system through ER-dependent mechanisms with an emphasis on the role of the recently described ER membrane signaling mechanisms.
RATS: A Robotic Arm Training System Designed for Rats (2021)

Abstract This paper presents a novel robotic system to characterize and retrain reaching in rats. This robot is intended to be a research platform for the rehabilitation of forelimb movements in rats. In this paper, we focus on the design of this robotic system. We present the design requirements, mathematical models, and details of the physical device. A parallel mechanism with a special alignment of the component chains is used to accommodate observed reaching motions of a rat’s forelimb. Additionally, we demonstrate the use of this robot to record forelimb trajectories. Three healthy rats were used to record repeated reaching motions while the robot applied nearly zero force. We believe that this robotic system can be used in future training studies with rats who have impaired arm motions due to a neurological insult.
Micro-transfer printed InGaAs photodetector on SOI platform (2023)

Transfer-printed InGaAs photodetectors are integrated on SOI by evanescent, grating and edge coupling, exhibiting responsivities of 0.7, 0.38 and 0.15 A/W, with dark currents of 48,47 and 400 nA at 0.6 V reverse bias respectively.