gebhart/patrepeval huggingface dataset:
A highly efficient synthesis of taxanes via the tandem Diels-Alder reaction (1995)

The tandem Diels-Alder reaction leads to a highly stereoselective two-step synthesis of a taxane nucleus from two readily available acyclic precursors in 50% overall yield.
Eye-gaze systems - An analysis of error sources and potential accuracy in consumer electronics use cases (2016)

Several generic CE use cases and corresponding techniques for eye gaze estimation (EGE) are reviewed. The optimal approaches for each use case are determined from a review of recent literature. In addition, the most probable error sources for EGE are determined and the impact of these error sources is quantified. A discussion and analysis of the research outcome is given and future work outlined.
Renewed relevance of new tests of the equivalence principle involving intrinsic properties of particles and antiparticles (2012)

The equivalence of the Shapiro delay for photons and (anti)neutrinos is the currently accepted lone test of the equivalence principle concerning intrinsic properties and quantum numbers of relativistic particles and seemingly constitute the only direct test for antiparticles. We show that due to the overwhelming contribution of the kinetic energy to the effective passive gravitational mass, Shapiro delay neither tests the equivalence principle nor anomalous long-range couplings related to the intrinsic properties and quantum numbers of the particles. In effect, the internal properties of the test particle are irrelevant in the context of weak equivalence principle (WEP) due to the relativistic suppression factor. The general result, independent of the nature of the long-range WEP-violating interaction assumed, underlines the potential significance of new tests.
ILP-based engineering change (2002)

We have developed a generic integer linear programming (ILP)-based engineering change (EC) methodology. The EC methodology has three components: enabling, fast, and preserving. Enabling EC provides a user with the means to specify the amount of flexibility and how this flexibility should be distributed throughout the solution so that one can guarantee that a specific set of EC demands can be satisfied while preserving the quality of the initially obtained solution. Fast EC conducts changes in a fraction of the time needed to solve the problem while preserving or in some cases improving the quality of the initial solution. Preserving EC maintains either user specified components of the solution or as much as possible of the initial solution while still guaranteeing an optimal solution to the altered problem instance. We applied the generic methodology to the Boolean satisfiability (SAT) problem. The effectiveness of all proposed approaches and algorithms is demonstrated on standard benchmarks.
Reflection Matrix Approach for Quantitative Imaging of Scattering Media (2020)

A new way of focusing waves creates a variety of new types of images that will be decisive for biomedical diagnosis in ultrasound imaging and optical microscopy, nondestructive evaluation in industry, and monitoring in geophysics.
Steady-State and Transient Analyses of an Induction Machine with Saturation of the Magnetizing Branch (1985)

A generalized induction motor model in the arbitrary reference frame that includes saturation of the magnetizing branch is presented. The model incorporates the spatially dependent or cross saturation effect. Steady-state, dynamic, and transient analyses and tests are presented to show the importance saturation has to induction motor dynamics. Comparisons with other simulation approaches show that the proposed model has clear advantages in computational accuracy and efficiency.
A hole-assisted fiber for wideband transmission from 1.0 µm to 1.6 µm (2009)

A novel hole-assisted fiber with single-mode propagation down to 1.0 µm and relatively low macro-bending loss up to L band is fabricated. The fiber also has low loss and large effective area properties.
Prognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub-optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation (2019)

Following beta-blocker uptitration, both achieved and change in heart rate were prognostically significant regardless of starting heart rate in SR, however, they were only significant in AF patients with high baseline heart rate.
Supplementary Figure 2 from Phase I Clinical Trial of Mixed Bacterial Vaccine (Coley's Toxins) in Patients with NY-ESO-1 Expressing Cancers: Immunological Effects and Clinical Activity (2023)

&lt;p&gt;PDF file, 64K, In-vitro immunostimulatory activity of MBV on PBMC.&lt;/p&gt;
Pontine reversible edema: a newly recognized imaging variant of hypertensive encephalopathy? (2000)

Although the typical imaging findings of hypertensive encephalopathy have been well described in the medical literature, the diagnosis can occasionally present a challenge. This may be related to the infrequency of patients presenting with hypertensive encephalopathy, relatively vague clinical
Remote Mode-Forming Over Multimode Fiber Employing Single-Ended Channel Estimation (2018)

Mode-forming over multimode fiber without access to the remote end is needed for endoscopic imaging and beam steering. We use reflective spatial pilots and transmitter-side MIMO to form uncoupled spatial and polarization modes at the remote end.
Immunochemical characterization of an IgG-binding protein ofStreptococcus suis (1998)

Several bacterial species express surface proteins with affinity for the constant region (Fc) of immunoglobulin (Ig) of different animal species. Previous studies from our group have reported the presence of an IgG-binding protein in various serotypes of Streptococcus suis. This molecule was also shown to bind in a non-immune fashion chicken IgY and to our knowledge this characteristic is unique. In the present study, by dot-blotting, we showed that the native protein, obtained by affinity chromatography, reacted more strongly with IgG from various animal species than the denatured material. Using a competitive enzyme-linked immunosorbent assay the affinity of the native 60-kDa protein (previously identified as a 52-kDa protein) towards IgG of various animal species was compared to pig IgG. Bovine, goat and human IgG were able to compete effectively with pig IgG whereas chicken IgY constituted a poor competitor. Peptide mapping analysis using denatured protein indicated that pig and bovine IgG recognized the same proteolytic fragment whereas chicken IgY did not. The smallest proteolytic fragment that retained the binding activity towards the IgG of the different animal species tested had a molecular mass of approximately 40 kDa. Fragments with Mr < 40 kDa showed specific binding activities. That is, the smallest fragment binding pig and bovine IgG had a Mr of 30 kDa whereas for goat and human IgG a fragment of less than 16 kDa still showed binding activity. Finally, we observed that antisera raised against a heat-shock protein of Pseudomonas aeruginosa reacted with the 60-kDa S. suis protein indicating that the S. suis 60-kDa protein is a member of the 60-kDa hsp family that possesses the characteristic of binding in a non-immune way mammalian IgG and chicken IgY.
Design of a wideband phased array transmitter using Rotman lens (2017)

This paper presents the design of a wideband 2-6 GHz phased array transmitter using Rotman lens. This transmitter can be used as a Radar system transmitter. It is considered lighter than a typical Radar transmitter and more cost effective since there is no need to use phase shifters. The design is implemented and analyzed using SystemVue simulation tool, where different components of the transmitter are designed according to required specifications. The transmitter includes a switched beam Rotman lens, eight driver amplifiers, eight power amplifiers and linear antenna array of eight-element. The Rotman Lens was designed using FEKO simulation tool and the extracted S-parameters are used as a model for the Rotman lens in SystemVue simulation. The performance of the complete system was analyzed in terms of the array factor and system power budget.
Dysregulation of the Hypothalamic-Pituitary-Adrenal Axis in Short Children With and Without Growth Hormone Deficiency (2000)

The effects of L-dopamine (LD) administration and insulin-induced hypoglycemia in adrenocorticotropin (ACTH) and cortisol secretion were studied in 14 short boys. LD caused moderate changes in both hormones. The four boys with isolated, idiopathic growth hormone (GH) deficiency (IGD) demonstrated a greater cortisol increase in response to hypoglycemia than the 10 boys with normal GH secretion. In at least some short children with IGD, abnormal regulation of the hypothalamic-pituitary-adrenal axis may be present.
HW/SW architecture for speech recognition acceleration (2013)

This paper describes a new hardware architecture for fast Acoustic Model scoring in embedded speech recognition systems by integrating an 8-way data-path with a NOR Flash array. This architecture localizes computation of critical algorithms and reduces decode latency and CPU load by 50% for large acoustic models, resulting in lower word error rates for natural language speech recognition.
Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor. (1986)

Isoquinoline sulfonamides have recently been shown to exert novel inhibitory effects on mammalian protein kinases by competitively binding to the ATP substrate site (Hidaka, H., M. Inagaki, S. Kawamoto, and Y. Sasaki, 1984, Biochemistry, 23: 5036-5041). We synthesized a unique analog of the previously reported compounds, 1-(5-isoquinolinesulfonyl) piperazine (C-I), in order to assess the role of protein kinases in modulating the agonist-stimulated oxidative burst of human polymorphonuclear leukocytes (PMN). Compound C-I, at micromolar concentration, markedly inhibited the release of superoxide anion from human PMN stimulated with phorbol myristate acetate or the synthetic diacylglycerol, 1-oleoyl-2-acetyl glycerol. These data are consonant with previously reported data which indicate that the calcium and phospholipid-dependent protein kinase, protein kinase C, serves as the intracellular receptor for these agonists. In contrast, superoxide anion production stimulated by the complement anaphylatoxin peptide C5a or the synthetic chemotaxin formyl-methionyl-leucyl-phenylalanine were not inhibited by C-I. These data suggest that parallel pathways exist for the agonist-stimulated respiratory burst of human neutrophils, only one of which utilizes the calcium and phospholipid-dependent protein kinase.
Development of high endothelial venule‐like characteristics in the spiral modiolar vein induced by viral labyrinthitis (1993)

The postcapillary venule is known to be the preferred site of lymphocyte migration into the extravascular compartment. In this study, induction of these high endothelial venule (HEV)-like vessels has been investigated by inoculation of live cytomegalovirus or inactivated virus into scala tympani of guinea pig cochleas. Endothelial cells of the spiral modiolar vein (SMV) were evaluated histologically 2 to 6 days following inoculation. The experimental group endothelial cells had larger nuclei and increased amounts of cytoplasm. In addition, many lymphocytes were adherent to and present within the vascular wall. Control SMV endothelia showed normal structure and morphology throughout the study. These findings reiterate that nonlymphoid tissues may develop HEV-like characteristics and suggest that HEV-like morphology may be acquired during an acute inflammatory condition in the cochlea.
The effect of interlamellar forces on the longitudinal acoustic mode of polyethylene crystals (1982)

Abstract The fold periods and longitudinal acoustic modes [LAMs] for isothermally crystallized polyethylene (PE) single crystals were determined in the dried state and in the presence of decalin and silicone oil. Upon swelling with decalin, the fold period increased by 7% while the LAM peak frequency decreased by approximately 1 cm −1 . Several possible explanations for the change in LAM frequency are discussed but the exact interpretation is open to question. No change in fold period was observed upon soaking a dried crystal mat in silicone oil. This fold period invariance along with the fact that silicone oil has no effect on the melting point of PE crystals indicates that there is no significant interaction between the oil and the methylene groups on the crystal surface. The effect of suspending crystals (which have never been dried down) in silicone oil should only be to increase the average interlamellar distance and, therefore, to reduce any interlamellar forces. It is shown that the LAM peak frequency for crystals suspended in silicone oil is the same as that for the dried crystals, indicating that interlamellar forces do not exert a significant perturbing influence on the LAM of polyethylene crystals.
Efficacy of Endoscopic Submucosal Dissection for Superficial Gastric Neoplasia in a Large Cohort in North America (2020)

Background & Aims Endoscopic submucosal dissection (ESD) is a widely accepted treatment option for superficial gastric neoplasia in Asia, but there are few data on outcomes of gastric ESD from North America. We aimed to evaluate the safety and efficacy of gastric ESD in North America. Methods We analyzed data from 347 patients who underwent gastric ESD at 25 centers, from 2010 through 2019. We collected data on patient demographics, lesion characteristics, procedure details and related adverse events, treatment outcomes, local recurrence, and vital status at the last follow up. For the 277 patients with available follow-up data, the median interval between initial ESD and last clinical or endoscopic evaluation was 364 days. The primary endpoint was the rate of en bloc and R0 resection. Secondary outcomes included curative resection, rates of adverse events and recurrence, and gastric cancer-related death. Results Ninety patients (26%) had low-grade adenomas or dysplasia, 82 patients (24%) had high-grade dysplasia, 139 patients (40%) had early gastric cancer, and 36 patients (10%) had neuroendocrine tumors. Proportions of en bloc and R0 resection for all lesions were 92%/82%, for early gastric cancers were 94%/75%, for adenomas and low-grade dysplasia were 93%/ 92%, for high-grade dysplasia were 89%/ 87%, and for neuroendocrine tumors were 92%/75%. Intraprocedural perforation occurred in 6.6% of patients; 82% of these were treated successfully with endoscopic therapy. Delayed bleeding occurred in 2.6% of patients. No delayed perforation or procedure-related deaths were observed. There were local recurrences in 3.9% of cases; all occurred after non-curative ESD resection. Metachronous lesions were identified in 14 patients (6.9%). One of 277 patients with clinical follow up died of metachronous gastric cancer that occurred 2.5 years after the initial ESD. Conclusions ESD is a highly effective treatment for superficial gastric neoplasia and should be considered as a viable option for patients in North America. The risk of local recurrence is low and occurs exclusively after non-curative resection. Careful endoscopic surveillance is necessary to identify and treat metachronous lesions.
From Kansas to Oz (1997)

article Free Access Share on From Kansas to Oz: collaborative debugging when a shared world breaks Authors: Randall B. Smith Sun Microsystems Laboratories Sun Microsystems LaboratoriesView Profile , Mario Wolczko at Sun Microsystems Laboratories at Sun Microsystems LaboratoriesView Profile , David Ungar Sun Microsystems Laboratories Sun Microsystems LaboratoriesView Profile Authors Info & Claims Communications of the ACMVolume 40Issue 4April 1997 pp 72–78https://doi.org/10.1145/248448.248461Published:01 April 1997Publication History 12citation400DownloadsMetricsTotal Citations12Total Downloads400Last 12 Months64Last 6 weeks55 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Domain-Specific Hybrid FPGA: Architecture and Floating Point Applications (2007)

This paper presents a novel architecture for domain-specific FPGA devices. This architecture can be optimised for both speed and density by exploiting domain-specific information to produce efficient reconfigurable logic with multiple granularity. In the reconfigurable logic, general-purpose finegrained units are used for implementing control logic and bit-oriented operations, while domain-specific coarse-grained units and heterogeneous blocks are used for implementing datapaths; the precise amount of each type of resources can be customised to suit specific application domains. Issues and challenges associated with the design flow and the architecture modelling are addressed. Examples of the proposed architecture for speeding up floating point applications are illustrated. Current results indicate that the proposed architecture can achieve 2.5 times improvement in speed and 18 times reduction in area on average, when compared with traditional FPGA devices on selected floating point benchmark circuits.
Multiple Independent Defective Suppressor-mutator Transposon Insertions in Arabidopsis: A Tool for Functional Genomics (1999)

Alain F. Tissier, Sylvestre Marillonnet, Victor Klimyuk, Kanu Patel, Miguel Angel Torres, George Murphy, Jonathan D. G. Jones, Multiple Independent Defective Suppressor-mutator Transposon Insertions in Arabidopsis: A Tool for Functional Genomics, The Plant Cell, Vol. 11, No. 10 (Oct., 1999), pp. 1841-1852
A platform for end-to-end mobile application infrastructure analytics using system log correlation (2017)

Monitoring and analyzing the performance of mobile applications is challenging when the applications rely on remote services and functioning networks. Root causes of failures and performance anomalies of client–server applications are difficult to pinpoint because of their distributed nature. In this paper, we introduce the Mobile Infrastructure Analytics System (MIAS), which helps efficiently detect and debug application faults in a distributed environment, holistically analyzing application and network activity across client devices, application servers, database servers, etc. MIAS collects hypertext transfer protocol (HTTP) session data and system logs from servers and instrumented mobile applications, automatically correlates HTTP sessions with server activity, detects anomalous behavior using statistical techniques, and extracts a small and relevant set of log entries for manual inspection. We show how faults were detected and root causes pinpointed just by glancing at the evidence, for a real-world bookstore mobile application.
Quorum regulatory small RNAs repress type VI secretion in Vibrio cholerae (2014)

Type VI secretion is critical for Vibrio cholerae to successfully combat phagocytic eukaryotes and to survive in the presence of competing bacterial species. V. cholerae type VI secretion system genes are encoded in one large and two small clusters. In V. cholerae, type VI secretion is controlled by quorum sensing, the cell-cell communication process that enables bacteria to orchestrate group behaviours. The quorum-sensing response regulator LuxO represses type VI secretion genes at low cell density and the quorum-sensing regulator HapR activates type VI secretion genes at high cell density. We demonstrate that the quorum regulatory small RNAs (Qrr sRNAs) that function between LuxO and HapR in the quorum-sensing cascade are required for these regulatory effects. The Qrr sRNAs control type VI secretion via two mechanisms: they repress expression of the large type VI secretion system cluster through base pairing and they repress HapR, the activator of the two small type VI secretion clusters. This regulatory arrangement ensures that the large cluster encoding many components of the secretory machine is expressed prior to the two small clusters that encode the secreted effectors. Qrr sRNA-dependent regulation of the type VI secretion system is conserved in pandemic and non-pandemic V. cholerae strains.
Rapamycin-regulated Control of Antiangiogenic Tumor Therapy Following rAAV-mediated Gene Transfer (2007)

Regulated gene expression may be required for the clinical development of certain gene therapies. Several approaches have been developed that allow pharmacologic control of transgene expression, including the dimerizer-regulated transcriptional system in which rapamycin or its analogs function as transcriptional inducers. These compounds can also act as direct antitumor agents via inhibition of mammalian target of rapamycin (mTOR). We describe the development of an optimized recombinant adeno-associated virus (AAV) expression cassette that allows dimerizer-regulated gene expression from a single vector in vitro and in vivo. After demonstrating multiple cycles of rapamycin-dependent transgene induction following a single administration of an AAV vector in vivo, application of this regulated AAV gene expression system to the pharmacologic control of antiangiogenic therapy was evaluated in preclinical tumor models. Dimerizer-regulated vectors were constructed encoding a soluble inhibitor of the vascular endothelial growth factor (VEGF) pathway. In two subcutaneous models of glioblastoma, regulated expression of the VEGF inhibitor via recombinant AAV-mediated gene transfer, in combination with rapamycin, was shown to decrease tumor growth rate significantly. The dual properties of rapamycin--as a transcriptional inducer and mTOR inhibitor--are exploited in combination with an AAV-encoded antiangiogenic agent to provide a novel approach for the treatment of malignant diseases.
Planning The National New Technology Telescope (NNTT): III. Primary Optics - Tests On A 1.8-M Borosilicate Glass Honeycomb Mirror (1986)

Materials for large primary mirrors should have low density, high elastic modulus, low coefficient of thermal expansion, dimensional stability over time, favorable polishing characteristics and affordable cost. The mirror&apos;s structural shape can contribute to high stiffness, low weight and a short thermal time constant. These characteristics can be provided by cast honeycomb borosilicate glass mirrors, but the coefficient of thermal expansion is high enough to require thermal control to achieve images at the 1/4-arcsecond level. This paper describes a series of tests performed on a 1.8-meter cast honeycomb mirror with an integral ventilation system for temperature control. Surface distortions have been related to the pattern of temperatures present, and the effect of ventilation on the thermal time constant has been explored. The results are extrapolated to larger size mirrors using finite-element analysis.