gebhart/patrepeval huggingface dataset:
Stateful hardware decompression in networking environment (2008)

Compression and Decompression can significantly lower the network bandwidth requirements for common internet traffic. Driven by the demands of an enterprise network intrusion system, this paper defines and examines the requirements of popular dictionary-based decompression in the real-time network processing scenario. In particular, a "stateful" decompression is required that arises out of the packet oriented nature of current networks, where the decompression of the data of a packet depends on the decompressed contents of its preceeding packets composing the same data stream. We propose an effective hardware decompression acceleration engine, which fetches the history data into the accelerator's fast memory on-demand and hides the associated latency by exploring the parallelism of the dictionary-based decompression process. We specify and evaluate various design and implementation options of the fetch-on-demand mechanism, i.e. prefetch most frequently used history, on-accelerator history buffer management, and reuse of fetched history data. Through simulation-based performance study, we show the effectiveness of the proposed mechanism on hiding the overhead of stateful decompression. We further show the effects of the design options and the impact on the overall performance of the network service stack of an intrusion prevension system.
Kinetic Model of Aluminum Behavior in Cement-Based Matrices Analyzed by Impedance Spectroscopy (2017)

International audience
A Multilayered Approach for Enhancing Rotorcraft Drive System Diagnostics (2014)

The Sikorsky Aircraft Corporation (SAC) and the U.S. Army Aviation Development Directorate (ADD) - Aviation Applied Technology Directorate (AATD) are jointly sponsoring the Capability-Based Operations and Sustainment Technology-Aviation (COST-A) program. The objective of COST-A is to demonstrate an integrated set of high-value diagnostics, prognostics, and system health management technologies that reduce the maintenance burden, without sacrificing safety, of six different rotorcraft systems, including the drivetrain. In general, existing rotorcraft health and usage monitoring systems (HUMS) systems are very effective, providing fault detection capability for critical drivetrain components, and providing other important HUMS functions for the aircraft. Despite the effectiveness of current HUMS systems, opportunities still exist for improvements. Technologies were therefore developed under COST-A to address these opportunities, including measurements or estimates of key drive system loads, improved data quality algorithms, new or improved condition indicators and related algorithms, and a drive system fault/failure mode reasoner. The focus of this paper is to highlight the COST-A drivetrain efforts developed and applied to improve drive system diagnostic performance.
Mannosylated Dextran Nanoparticles: A pH-Sensitive System Engineered for Immunomodulation through Mannose Targeting (2011)

Biotherapeutic delivery is a rapidly growing field in need of new materials that are easy to modify, are biocompatible, and provide for triggered release of their encapsulated cargo. Herein, we report on a particulate system made of a polysaccharide-based pH-sensitive material that can be efficiently modified to display mannose-based ligands of cell-surface receptors. These ligands are beneficial for antigen delivery, as they enhance internalization and activation of APCs, and are thus capable of modulating immune responses. When compared to unmodified particles or particles modified with a nonspecific sugar residue used in the delivery of antigens to dendritic cells (DCs), the mannosylated particles exhibited enhanced antigen presentation in the context of major histocompatibility complex (MHC) class I molecules. This represents the first demonstration of a mannosylated particulate system that enables enhanced MHC I antigen presentation by DCs in vitro. Our readily functionalized pH-sensitive material may also open new avenues in the development of optimally modulated vaccine delivery systems.
Canaricam: capabilities and current status (2007)

"The University of Florida has developed a versitile mid-infrared camera for the 10.4-m Gran Telescopio CA-NARIAS. The CanariCam instrument uses a single 320?240 pixel arsenic-doped silicon detector, coolded toless than 10K. CanariCam will be ready for 1st light observations on the GTC, o?ering di?raction limitedimaging through an extensive set of lters, low- and moderate-resolution spectroscopy, a coronographic modeand, for the rst time at mid-infrared wavelengths, a dual-beam polarimeter mode. We breiy describe theinstrument and present recent laboratory testing of the instrument"
MICROPUNCTURE STUDY OF PROTEIN CONCENTRATION IN GLOMERULAR FLUID IN THE NEWT (1971)

The investigation to elucidate the mode of permeability of glomerular capillary membranes for protein is a keypoint for the clarification of the mechanism of proteinuria. In order to clarify to this mechanism, the experiments were performed using the newts, in which the glomerular capsules are easy accessible by the micropuncture technique.
Prostate Size and Configuration in Adults with Bladder Exstrophy (1993)

A total of 13 men born with classical bladder exstrophy underwent magnetic resonance imaging examination of the pelvis to evaluate the size and configuration of the prostate and pelvic organs. Mean patient age was 25.2 years (range 19 to 38). Of the patients 4 are voiding per urethram and 9 have undergone urinary division. Measurements included prostate volume, weight and maximum axial cross sectional area; pubic diastasis, and seminal vesicle size. The mean prostatic cross sectional area was 10.1 +/- 3.4 cm.2. The mean estimated prostatic volume and weight were 20.7 +/- 8.2 cc and 21.7 +/- 8.6 gm., respectively. The mean seminal vesicle length and width were 2.1 +/- 0.99 and 1.1 +/- 0.38 cm., respectively. The volume, weight and maximum cross sectional area of the prostate appear normal compared to published norms. In none of the patients did the prostate extend circumferentially around the urethra and the urethra was anterior to the prostate in all patients. Also, the puborectalis muscle group was widely separated and only provided lateral support of the prostate in patients who were continent and who had undergone prior posterior iliac osteotomy. Thus, the attainment of continence in this complex group of patients is multifactorial and prostate growth as evaluated by magnetic resonance imaging may not influence continence in these patients.
Electron transport in a molecularly doped polymer (1991)

Electron transport in films of an electron acceptor, n-butyl 9-dicyanomethylenefluorene-4-carboxylate (BDFC) stabilized with an electron donor, N,N'-diphenyl-N-N'-bis(3-methylphenyl)-(1-1'-biphenyl)-4-4'diamine (TPD) and dispersed in bisphenol A polycarbonate polymer matrix was investigated. Electron mobility was determined using the time-of-flight technique and was found to be strongly dependent on the electric field. The trapped space charge, which results in the residual potential, is distributed uniformly in the bulk of the charge-transport layer.
Abstract 2296: Identification of novel nuclear receptor targets in estrogen receptor negative breast cancer (2011)

Abstract Introduction: Estrogen receptor (ER)-negative breast cancer has a particularly poor prognosis, and there are limited targeted agents for this subtype. Aims and Methods: To identify nuclear receptor (NR) targets, we did microarray analysis of 227 ER-negative tumors as assessed by immunohistochemistry, and performed hierarchical clustering using 41 NRs, and prediction analysis of microarrays (PAM) across the clustered groups. Cell lines were matched to identified groups using previously published data. Clinical correlations were made using previously published breast cancer datasets. Results and Conclusion: The 41 NRs clustered the tumors into 5 distinct groups. We found that the androgen receptor (AR) was the highest ranked discriminator of these groups followed by ERα. Group 1 (14% of the tumors) was characterized by elevated ERRα and RXR expression. Group 2 (9%) was characterized by higher expression of the orphan receptor NURR1. Group 3 was the largest group (37%), and showed high level expression of PPARα. Group 4 (16%) expressed higher levels of PPARγ. Group 5 (24%) demonstrated particularly high relative expression of AR, and also showed higher expression of ERα and ERRα. We used previously published microarray data to match cell lines to the NR groups using the scoring matrix developed in the PAM analysis. These cell lines are currently being tested for response to NR agonists and antagonists in growth (MTT, soft-agar, mammosphere) and apoptotic assays. We used a previously published microarray data set with long-term follow up information to identify potential differences in outcomes for the different NR subtypes. While we found no significant differences between the groups, the sample size was quite low for each subtype (n∼15 per group). In summary, we have identified several novel ER-negative tumor groups by different expression level of NRs which may contribute to the prediction of breast cancer molecular subtypes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2296. doi:10.1158/1538-7445.AM2011-2296
G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women (2004)

G2736A polymorphism of the TSC gene is a genetic predisposing factor for essential hypertension in Japanese women.
ChemInform Abstract: A Photochemically Triggered DNA Cleaving Agent: Synthesis, Mechanistic and DNA Cleavage Studies on a New Analogue of the Antitumor Antibiotic Dynemicin. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Intermittent warm blood versus cold crystalloid cardioplegia for myocardial protection: a propensity score-matched analysis of 12-year single-center experience (2014)

Blood cardioplegia was identified as an independent risk factor for elevated levels of CK-MB after CABG, but was associated with lower AST levels. The authors conclude that the type of cardioplegia had no significant influence on clinical outcome.
Three-dimensional stereo reconstruction of a mass of radioactive coils after embolization of cerebral aneurysms (2004)

Endovascular treatment of cerebral aneurysms with radioactive coils may prevent recanalization after embolization. This strategy requires an accurate estimation of the volume of the mass of coils to evaluate the intervention dosimetric success. The purpose of this work is to develop a computer-aided method to estimate the coil volumes using only two orthogonal angiographic projections. The originality of the method resides in the direct reconstruction of two 3-D contours of the mass of coils and the following variational interpolation of the 3-D surface in order to estimate its volume. Validated by simulations, the reconstruction algorithms could estimate the enclosed volumes with an average error of 2.9% and a variability of 2.5%. In addition, the feasibility of the method was also demonstrated using clinical images. Results showed that this reconstruction technique could quickly generate an accurate and realistic 3-D shape of the mass of coils without interfering with an ongoing clinician procedure.
Formation and Properties of Positively Charged Colloids Based on Polyelectrolyte Complexes of Biopolymers (2004)

Formation of colloids based on polyelectrolyte complexes (PECs) was mainly studied with synthetic polyelectrolytes. In this study, we describe the elaboration of positively charged PEC particles at a submicrometer level obtained by the complexation between two charged polysaccharides, chitosan as polycation and dextran sulfate (DS) as polyanion. The complexes were elaborated by dropwise addition of default amounts of DS to excess chitosan. Quasi-elastic light scattering was used to investigate in detail the influence of the characteristics of components (chain length, degree of acetylation) and parameters linked to the reaction of complexation (molar mixing ratio, ionic strength, concentration in polymer) on the sizes and polydispersity of colloids. Chain length of chitosan is the major parameter affecting the dimensions of the complexes, high molar mass chitosans leading to the largest particles. Variations of hydrodynamic diameters of PECs with the molar mass of chitosan are consistent with a mechanism of particle formation through the segregation of the neutral and then hydrophobic blocks of the polyelectrolyte complexed segments. Resulting particles display probably a structure constituted by a neutral core surrounded by a chitosan shell ensuring the colloidal stabilization. Such a structure was evidenced by measurements of electrophoretic mobilities revealing that the positive charge of particles was decreasing with pH, in relation with the neutralization of excess glucosamine hydrochloride moieties.
Lithium sulfur batteries and electrolytes and sulfur cathodes thereof (2023)

Lithium sulfur battery cells that use water as an electrolyte solvent provide significant cost reductions. Electrolytes for the battery cells may include water solvent for maintaining electroactive sulfur species in solution during cell discharge and a sufficient amount of a cycle life-enhancing compound that facilitates charging at the cathode. The combination of these two components enhances one or more of the following cell attributes: energy density, power density and cycle life. For instance, in applications where cost per Watt-Hour (Wh) is paramount, such as grid storage and traction applications, the use of an aqueous electrolyte in combination with inexpensive sulfur as the cathode active material can be a key enabler for the utility and automotive industries, for example, providing a cost effective and compact solution for load leveling, electric vehicles and renewable energy storage. Sulfur cathodes, and methods of fabricating lithium sulfur cells, in particular for loading lithium sulfide into the cathode structures, provide further advantages.
TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients. (2020)

Abstract Background: SARS-coronavirus-2 enters host cells through binding of the Spike protein to ACE2 receptor and subsequent S priming by the TMPRSS2 protease. We aim to assess differences in both ACE2 and TMPRSS2 expression in normal tissues from oral cavity, pharynx, larynx and lung tissues as well as neoplastic tissues from the same areas. Methods: The study has been conducted using the TCGA and the Regina Elena Institute databases and validated by experimental model in HNSCC cells. We also included data from one COVID19 patient who went under surgery for HNSCC. Results: TMPRSS2 expression in HNSCC was significantly reduced compared to the normal tissues. It was more evident in women than in men, in TP53 mutated versus wild TP53 tumors, in HPV negative patients compared to HPV positive counterparts. Functionally, we modeled the multivariate effect of TP53, HPV, and other inherent variables on TMPRSS2. All variables had a statistically significant independent effect on TMPRSS2. In particular, in tumor tissues, HPV negative, TP53 mutated status and elevated TP53-dependent Myc-target genes were associated with low TMPRSS2 expression. The further analysis of both TCGA and our institutional HNSCC datasets identified a signature anti-correlated to TMPRSS2. As proof-of-principle we also validated the anti-correlation between microRNAs and TMPRSS2 expression in a SARS-CoV-2 positive HNSCC patient tissues Finally, we did not find TMPRSS2 promoter methylation. Conclusions: Collectively, these findings suggest that tumoral tissues, herein exemplified by HNSCC and lung cancers might be more resistant to SARS-CoV-2 infection due to reduced expression of TMPRSS2. These observations may help to better assess the frailty of SARS-CoV-2 positive cancer patients.
Partial-response decoding of rate 1/2 modulation codes for digital storage (2003)

In digital storage systems, receivers for rate 1/2 modulation codes are usually oversampled by a factor of two with respect to the data stream that they attempt to reconstruct. It is shown that oversampling can be avoided by detecting a decimated ternary signal, from which the original data can be recovered by a simple decoder. A method is described to find all such decoders for a given rate 1/2 code. Examples treated are modified frequency modulation, Miller-squared, and two-to-seven. Mean-square performances of the old and new reception schemes are compared for a Lorentzian channel. The relative merits are found to depend quite heavily on the information density. The results obtained seem to contradict the belief that high-density performance benefits from a large minimum run length.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Monofunctionalized Cobaltocenium Compounds by Dediazoniation Reactions of Cobaltoceniumdiazonium Bis(hexafluorophosphate) (2016)

Monofunctionalized cobaltocenium salts are obtained for the first time from cobaltoceniumdiazonium bis(hexafluorophosphate) with various nucleophiles via Sandmeyer-type and related reactions. For successful conversions, reaction conditions are quite critical: either standard solution chemistry in nitromethane or solvent-free ball milling proved necessary, depending on the type of reactant. By this synthetic approach valuable synthons such as iodocobaltocenium and azidocobaltocenium salts are accessible that open up new vistas in cobaltocenium chemistry. Spectroscopic characterization by NMR, IR, HRMS, and single-crystal structure analysis as well as the results of electrochemical studies are reported. Derivatives with two reversible reductions show the expected relation of the half-wave potentials with the Hammett substituent parameter σp of the respective substituent with a slightly larger slope for the first reduction. The carboxylic acid (reductive deprotonation of the −COOH functionality), the iodo (protodehalogenation), and the azido derivatives undergo irreversible subsequent reactions after primary reduction.
Neuromorphic Benchmarking at the Neural Exploration and Research Laboratory. (2020)

Abstract not provided.
First Synthesis of Isotactic Poly(9-alkyl1-9-alkyl2fluorene) via Directed Aryl−Aryl Coupling of Chiral AB-Type Monomers (2009)

Nonsymmetrically substituted chiral 9-alkyl1-9-alkyl2fluorene monomers of the AB type allow for their directed, stereoregular aryl−aryl cross-coupling after Suzuki leading to isotactic poly(9-alkyl1-9-alkyl2fluorene). As expected, the isotactic poly(9-dodecyl-9-methylfluorene) i-PF1-12 of this study shows an increased solid state ordering and distinctly different thermal properties when compared to its corresponding atactic, stereoirregular polyfluorene counterpart a-PF1-12. This and other isotactic polyfluorene derivatives will be interesting building blocks for the generation of chiral, all-conjugated block copolymers.
P3‐068: INCREASED LEVELS OF Aβ42 DECREASE THE LIFE SPAN OF OB/OB MICE WITH DYSREGULATION OF MICROGLIA AND ASTROCYTES (2019)

Clinical studies have indicated that diabetes is associated with Alzheimer's disease (AD) and neurodegeneration. Although the mechanisms underlying these associations remain elusive, the bidirectional interactions between diabetes and AD may contribute. Both diabetes and AD significantly reduce life expectancy. We generated AppNL-F/wt knock-in; ob/ob mice by crossing AppNL-F/wt knock-in mice and ob/ob mice to investigate whether amyloid-β (Aβ) affects the lifespan of ob/ob mice. AppNL-F/wt knock-in; ob/ob mice displayed the shortest lifespan compared to wild-type mice, AppNL-F/wt knock-in mice, and ob/ob mice. Notably, the Aβ42 levels were increased at minimum levels before deposition in AppNL-F/wt knock-in mice and AppNL-F/wt knock-in; ob/ob mice, and comparable levels were observed between these two groups at 18 months of age. No differences in the levels of several neuronal markers were observed between mice at this age. On the other hand, we observed increased levels of GFAP, an astrocyte marker, in AppNL-F/wt knock-in; ob/ob mice, while the levels of several microglial markers, including TREM2, were decreased in both ob/ob mice and AppNL-F/wt knock-in; ob/ob mice. The increase in GFAP levels was not observed in young AppNL-F/wt knock-in; ob/ob mice. The increased Aβ42 levels may decrease the lifespan of ob/ob mice, which is associated with the dysregulation of microglia and astrocytes. Based on these findings, the imbalance in these neuroinflammatory cells may provide a clue to the mechanisms by which the interaction between diabetes and early AD reduces life expectancy.
Abstract 3816: Efficacy of CDX-1140, an agonist CD40 antibody, in preclinical tumor models (2018)

Abstract CD40 on antigen presenting cells plays a critical role in the induction of effective innate and adaptive immune responses. In contrast, CD40 signaling on certain malignant cells, particularly B cell lymphomas, inhibits proliferation or triggers apoptotic cell death. Thus, two independent mechanisms provide opportunities for the use of agonist anti-CD40 monoclonal antibodies in cancer therapy: enhancement of anti-tumor immunity, and direct inhibition of tumor growth. CDX-1140 is a human IgG2 antibody selected from a panel of fully human mAbs specific for CD40 generated by hybridoma technology from human Ig transgenic mice. We previously demonstrated the potent immune enhancing effects of CDX-1140 using in vitro models and in non-human primates. CDX-1140 was shown to activate dendritic cells and B cells in an Fc receptor independent manner. CDX-1140 does not bind to the CD40L binding site, and synergizes with CD40L in stimulation of the CD40 receptor and subsequent functional activities. Here we further characterized the anti-tumor activity of CDX-1140 on CD40 positive tumors using xenograft models in immunodeficient mice. Using the Ramos and Raji human lymphoblastoma cell lines, CDX-1140 was shown to attenuate tumor growth and prolong survival. Addition of CDX-1140 and human PBMC was highly effective at promoting complete rejection of both Ramos and Raji tumors. Importantly, the epithelial EJ138 bladder carcinoma cell line was also highly sensitive to CDX-1140 treatment. For example, in a study where mice received EJ138 cells subcutaneously, all animals that were treated with 300 µg of CDX-1140 on days 1, 8, and 15, showed suppression of tumor growth through day 60, in comparison to saline-treated animals which developed significant tumors in 7 of 8 animals. These data support the potential of CDX-1140 for direct anti-tumor effects on CD40-positive tumors (including epithelial tumors) that may supplement its activity as an immune activating agent. CDX-1140 is currently in a phase 1 dose-escalation study in patients with advanced solid tumors. Citation Format: Lawrence J. Thomas, Li-Zhen He, James Testa, Anna Wasiuk, Jeffrey Weidlick, Crystal Sisson, Laura A. Vitale, Thomas O'Neill, Eric Forsberg, Catherine D. Pilsmaker, Lauren E. Gergel, Elizabeth Q. Do, James Boyer, April R. Baronas, Mallary Rocheleau, Michelle E. Grealish, Kathleen M. Borrelli, Henry C. Marsh, Tibor Keler. Efficacy of CDX-1140, an agonist CD40 antibody, in preclinical tumor models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3816.