gebhart/patrepeval huggingface dataset:
Abstract 2108: New analogues of benzyl-isothiourea showed Rb-Raf disruption and anti-cancer activity (2011)

Abstract The retinoblastoma tumor suppressor protein Rb, is a vital regulator of the mammalian cell cycle which is inactivated by phosphorylation. We had shown that Raf-1 kinase binds and phosphorylates Rb early in the G1 phase facilitating its subsequent phosphorylation by cyclin dependent kinases. This phosphorlation released transcriptionally active E2Fs from Rb to facilitate S-phase entry. Disruption of Rb-Raf protein-protein interaction could prevent proliferation and angiogenesis, leading to inhibition of tumor growth in mouse models. We had earlier identified an orally active small molecule, Rb/Raf-1 disruptor 251 (RRD-251) that potently and selectively disrupts Rb/Raf-1 but not Rb/E2F, Rb/prohibitin, Rb/cyclin E or Rb/HDAC interactions. Here, we have made efforts to analyze additional analogues of RRD251; we focused on XW-19B and XW-35B. These compounds inhibited Rb-Raf interaction in vitro and in vivo as shown by ELISA and Immunoprecipitation-Western blot analysis. They also inhibited cell viability, proliferation, migration, invasion, angiogenesis and adherence-independent growth of human lung cancer cell lines A549. XW-19B inhibited tumor growth significantly in human A549 xenograft model in nude mice, compared to control while XW-35B showed certain amount of toxicity to animals at 50MPK. Overall, these results showed that Rb-Raf disruptors XW-19B and XW-35B have potential anticancer activity. Thus, selective targeting of Rb/Raf-1 interaction seems to be a promising approach for developing novel chemotherapeutic agents. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2108. doi:10.1158/1538-7445.AM2011-2108
Improving Vehicle Positioning and Visual Feature Estimates through Mutual Constraint (2007)

An argument is presented that a two-way relationship between position and visual information can be utilized to improve estimates of vehicle position as well as the interpretation of the surrounding environment. Simulation results for a formulation based on dynamic Bayesian networks illustrate that the belief in vehicle position is influenced by the measured visual features, while the belief in the value of said visual features is in turn influenced by GPS measurements of vehicle position. The weight of these influences, as well as the uncertainty of the resulting state estimates, depends directly upon the rate-of-change of the observed features. This information sharing approach represents a successful integration of these two technologies that leads to more plausible vehicle positioning and visual feature estimation that will be useful for purposes of automated driving and navigation systems.
Determination of Peptide Amide Configuration in a Model Amyloid Fibril by Solid-State NMR (1997)

The β-amyloid proteins (Aβ), especially the variant Aβ1−42, are the primary constituent of the amyloid plaques which are characteristic of Alzheimer's disease (AD). The C-terminus of Aβ has been identified as crucial for rapid amyloid formation. A 9-residue C-terminal fragment of Aβ (designated β34−42, with sequence LMVGGVVIA) forms a structured aggregate which is classified as an amyloid fibril based primarily on its morphological and solubility properties and the classic cross-β fiber diffraction pattern it displays. We have adopted this aggregate as a model of the Aβ-dominated amyloid plaques associated with AD. Previous results from a series of internuclear 13C−13C distance measurements along the peptide backbone indicate that the β34−42 backbone conformation differs considerably from that of the classic β-sheet, possibly including an unusual cis amide bond in the peptide's central glycyl−glycyl region. Here we report evidence which demonstrates the presence of a trans configuration at the peptide linkage between these residues. The evidence derives from solid-state NMR static echo and n = 2 rotational resonance experiments which probe the orientation of the 13C carbonyl chemical shift anisotropy (CSA) tensor of the peptide bond with respect to the dipolar tensor connecting the carbonyl carbon to the 13C-labeled α-carbon on the succeeding residue.
Accelerating video carving from unallocated space (2013)

Video carving has become an essential tool in digital forensics. Video carving enables recovery of deleted video files from hard disks. Processing data to extract videos is a computationally intensive task. In this paper we present two methods to accelerate video carving: a method to accelerate fragment extraction, and a method to accelerate combining of these fragments into video segments. Simulation results show that complexity of video fragment extraction can be reduced by as much as 75% with minimal impact on the videos recovered.
Cu/sub x/S back contact for CdTe solar cells (2003)

Copper sulfide (Cu/sub x/S) films were studied as a back contact material for CdTe solar cells. The Cu/sub x/S films were made by chemical bath deposition in aqueous solution. Annealing at 200/spl deg/C in Ar improved the performance of the solar cells. Using the CdS/CdTe/Cu/sub x/S/C structure, an open-circuit voltage (V/sub oc/) higher than 840 mV and an energy conversion efficiency higher than 11% were obtained.
Bedarfsanalyse für Gesundheitsförderung und Prävention im Landkreis Marburg-Biedenkopf (2019)

Im Rahmen des Projekts „Gesundheit fördern – Versorgung stärken“ des Landkreises Marburg-Biedenkopf wurde eine Bedarfsanalyse durchgeführt, um in einem zweiten Schritt gesundheitsfördernde und präventive Maßnahmen in den Kommunen (hier = Gemeinden, Städten, Stadtteile) umsetzen zu können. Die Maßnahmen sollen an kommunale Strukturen und Bedarfe angepasst werden.
First demonstration of electrical injection lasing in the novel dilute nitride Ga(NAsP)/GaP‐material system (2006)

Quantum well heterostructures (QWH) in the novel dilute nitride Ga(NAsP)/GaP-material system have been grown pseudomorphically strained to GaP-substrate by metal organic vapour phase epitaxy (MOVPE). The high crystalline perfection has been determined by detailed structural analysis applying high-resolution X-ray diffrcation (XRD). The active QWH have been embedded in (AlGa)P/GaP-waveguide structures. Electrical injection lasing has been verified for broad area laser devices at low temperatures (80K–150K) for the first time in this novel material system. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
A biomechanical evaluation of occipitocervical instrumentation: screw compared with wire fixation (1999)

Occipitocervical fixation can be performed using a variety of techniques; all bestow significant immobilization compared with the destabilized spine. All methods tested in this study were susceptible to fatigue and loss of reduction and were weakest in resisting vertical settling. Screw fixation of the occiput-C2 reduces the number of vertebral segments that are necessary to incorporate into the fusion construct while providing superior immobilization and resistance to fatigue and vertical settling compared with sublaminar methods.
Predicting the image quality of color overhead transparencies using a color-appearance model (1997)

The color-image quality of color overhead transparencies depends on properties of the imaging system used to create the transparency and illuminating and viewing conditions of the transparency such as the projector's spectral power distribution, projector distance from the screen, and luminance, ambient lighting, screen gonio-spectral reflectance factor, and viewing distance and geometry. As different visual fields and/or luminance of those fields, some of these illuminating and viewing conditions can be taken into suitable account using color-appearance models. A visual experiment is performed to determine whether color-appearance correlates of visual perception could be used to predict color-image quality for this imaging modality. The Hunt 1991 color-appearance model is used to define correlates of hue, brightness, colorfulness, lightness, and chroma for both pictorial and business-graphic scenes viewed under several combinations of ambient illuminance and projector luminance. Gamut volume is defined based on either absolute attributes-hue, brightness, and colorfulness-or relative attributes-hue, lightness, and chroma. Seventeen observers performed a preference experiment generating interval scales of color-image quality. It is found that gamut volume defined by using correlates of hue, brightness, and colorfulness well predicted color-image quality. Of these correlates, colorfulness was the most important factor.
Mirtazapine – A Multifunctional Drug: Low Dose for Akathisia (2011)

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An Immune Cell Recirculation-Enabled Microfluidic Array to Study Dynamic Immunotherapeutic Activity in Recapitulated Tumor Microenvironment (2022)

ABSTRACT The efficacy of immunotherapeutic treatment protocols to enable immune cell mediated treatment of cancer is significantly modulated in the presence of tumor microenvironment (TME) which is a key factor in providing both a physical barrier and immunosuppressive stimuli. Herein, we developed a recirculating, high-throughput microfluidic cell array to capture these crucial players – cytotoxic T cells in circulation, endothelium, and tumor stroma. The system consisted of a three-layered cell array spatially emulating TME, with T cell circulation sustained via fluidic recirculating circuits. This allowed us to study the dynamic TME/circulation system and cancer cell response thereof. The system further revealed that tumor endothelium exhibited a hindrance to T cell infiltration into the breast cancer tumor compartment, which was alleviated when treated with anti-human PD-L1 antibody. The other key stromal component, cancer associated fibroblasts, further attenuated T cell infiltration, and led to reduced apoptosis activity in cancer cells. These results confirm the capability of our tumor-on-a-chip system to recapitulate some key immune cell interactions with the reconstructed TME, along with demon-strating as the feasibility of using this system for high-throughput cancer immunotherapeutic screening.
Beneficial influence of bifidobacterium infantis feeding on secretagogue response in rats recovering from colitis (2005)

Aim: To examine the effects of the probiotic Bifidobacterium infantis on colonic electrolyte transport in rats recovering from colitis.
Advanced Statcom Control for Stand Alone Induction Generator Power Sources (2008)

In this paper a control strategy for an induction generator based stand-alone power system is examined. The tested system consists of a prime motor, an induction generator, a Voltage Source Inverter STATCOM and a variable load. The paper focus on dynamics performance and stability margin of the system under alternative control strategies. The regulation strategy is based on the control of dc and ac voltage profiles in order to contain the ac voltage droop on load. The control acts on prime mover torque and delay angle between inverter and induction generator voltages. The results of numerical simulation evidence the feasibility of control strategy.
Diesel exhaust particles activate human bronchial epithelial cells to express inflammatory mediators in the airways: A review (2000)

These results suggested that DEP activate NF-kappaB, which might be an important pathway for the expression of inflammatory cytokines in vitro.
Fast Exponentiation Using Split Exponents (2011)

We propose a new method to speed up discrete logarithm (DL)-based cryptosystems by considering a new variant of the DL problem, where the exponents are formed as e <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> + e <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> for some fixed a and two integers e <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> , ae <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> with a low weight representation. We call this class of exponents split exponents, and we show that with certain choice of parameters the DL problem on split exponents is essentially as secure as the standard DL problem, while the exponentiation operation using exponents of this class is significantly faster than best exponentiation algorithms given for standard exponents. For example, the speed of scalar multiplication on the standard Koblitz curve K163 is estimated to be accelerated by up to 51.5 % and 23.5 % at the cost of memory for one precomputed point, compared to the TNAF and window TNAF methods, respectively. As for security, we show that the provable security of the DL problem using split exponents is only by a small constant, e.g., 1/4, worse than the security of the standard DL problem. Split exponents can be adopted to speed up various DL-based cryptosystems. We exemplify this on the recent CCA-secure public key encryption of Bellare, Kohno, and Shoup.
Solution-Processed All-Perovskite Multi-Junction Solar Cells (2019)

Summary Multi-junction device architectures can increase the power conversion efficiency (PCE) of photovoltaic (PV) cells beyond the single-junction thermodynamic limit. However, these devices are challenging to produce by solution-based methods, where dissolution of underlying layers is problematic. By employing a highly volatile acetonitrile(CH3CN)/methylamine(CH3NH2) (ACN/MA) solvent-based perovskite solution, we demonstrate fully solution-processed absorber, transport, and recombination layers for monolithic all-perovskite tandem and triple-junction solar cells. By combining FA0.83Cs0.17Pb(Br0.7I0.3)3 (1.94 eV) and MAPbI3 (1.57 eV) junctions, we reach two-terminal tandem PCEs of more than 15% (steady state). We show that a MAPb0.75Sn0.25I3 (1.34 eV) narrow band-gap perovskite can be processed via the ACN/MA solvent-based system, demonstrating the first proof-of-concept, monolithic all-perovskite triple-junction solar cell with an open-circuit voltage reaching 2.83 V. Through optical and electronic modeling, we estimate the achievable PCE of a state-of-the-art triple-junction device architecture to be 26.7%. Our work opens new possibilities for large-scale, low-cost, printable perovskite multi-junction solar cells.
Synthesis of diazadibenzo‐18‐crown‐6 ligands with appended chromophoric and fluorophoric groups as potential metal ion chemosensors (2001)

Abstract Six new diazadibenzo‐18‐crown‐6 ligands substituted with two each of 8‐hydroxyquinoline (7), 8‐amino‐quinoline (attached through its C‐2 or C‐7 position) ( 12 and 13 ), 8‐methoxyquinoline ( 18 ), 5‐chloro‐8‐methoxyquinoline ( 19 ), and dansylamidoethyl ( 21 ) side arms were synthesized as potential metal ion chemosensors and potential reagents for the selective extraction of certain metal ions from aqueous solutions. Ligands 7, 12, 13, 18 , and 19 were synthesized by reductive amination of diazadibenzo‐18‐crown‐6 ( 5 ) and the appropriate quinolinecarboxaldehydes. Bis(dansylamidoethyl)‐substituted ligand 21 was synthesized by treating diazacrown ether 5 with N ‐dansylaziridine ( 20 ).
Recyclable shape‐memory polymer: Poly(lactic acid) crosslinked by a thermoreversible Diels–Alder reaction (2009)

Abstract An intelligent shape‐memory polymer was made through the synthesis of poly(lactic acid) macromonomers with furanyl groups and crosslinking with linkers with maleimidyl groups. The thermoreversible covalent bonds formed by the Diels–Alder reaction between these groups made this polymer recyclable (i.e., environmentally friendly). The structure of the polymer was also studied. A defect of the structure, a dissociated moiety of the thermoreversible bonding, was strongly affected by the reaction conditions and was investigated with UV spectroscopy, which was used to monitor the concentration of the maleimidyl groups. The relation between the flexibility of the linker and the strength and inner stress of the polymer was also evaluated. Reducing the number of defects and relaxing the inner stress were found to increase the strength of the shape‐memory polymer. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Visualizing Specific Cross-Protomer Interactions in the Homo-Oligomeric Membrane Protein Proteorhodopsin by Dynamic-Nuclear-Polarization-Enhanced Solid-State NMR (2015)

Membrane proteins often form oligomeric complexes within the lipid bilayer, but factors controlling their assembly are hard to predict and experimentally difficult to determine. An understanding of protein-protein interactions within the lipid bilayer is however required in order to elucidate the role of oligomerization for their functional mechanism and stabilization. Here, we demonstrate for the pentameric, heptahelical membrane protein green proteorhodopsin that solid-state NMR could identify specific interactions at the protomer interfaces, if the sensitivity is enhanced by dynamic nuclear polarization. For this purpose, differently labeled protomers have been assembled into the full pentamer complex embedded within the lipid bilayer. We show for this proof of concept that one specific salt bridge determines the formation of pentamers or hexamers. Data are supported by laser-induced liquid bead ion desorption mass spectrometry and by blue native polyacrylamide gel electrophoresis analysis. The presented approach is universally applicable and opens the door toward analyzing membrane protein interactions within homo-oligomers directly in the membrane.
Neutralization of the anthrax toxin by antibody-mediated stapling of its membrane penetrating loop (2021)

Abstract Anthrax infection is associated with severe illness and high mortality. Protective antigen (PA) is the central component of the anthrax toxin, which is the main virulent factor of anthrax. Upon endocytosis, PA opens a pore in the membranes of endosomes, through which the toxin’s cytotoxic enzymes are extruded. The PA pore is formed by a cooperative conformational change where PA’s membrane-penetrating loops associate, forming a hydrophobic rim that pierces the membrane. Due to its crucial role in anthrax progression, PA is an important target of monoclonal antibodies-based therapy. cAb29 is a highly effective neutralizing antibody against PA. We determined the cryo-EM structure of PA in complex with the Fab portion of cAb29. We found that cAb29 neutralizes the toxin by clamping the membrane-penetrating loop of PA to a static region on PA’s surface, thereby preventing pore formation. Therefore, our results provide the structural basis for the antibody-based neutralization of PA and bring to focus the membrane-penetrating loop of PA as a target for the development of better anti-anthrax vaccines.
Supplementary Figure 3 from Imaging Pharmacodynamics of the α-Folate Receptor–Targeted Thymidylate Synthase Inhibitor BGC 945 (2023)

Supplementary Figure 3 from Imaging Pharmacodynamics of the α-Folate Receptor–Targeted Thymidylate Synthase Inhibitor BGC 945
Development of Scallop Cut Type Damper Seal for Centrifugal Compressors (2014)

This paper deals with a new type of damper seal developed for a high-pressure centrifugal compressor. Honeycomb seals and hole pattern seals are popularly used as damper seals and provide superior rotordynamic damping characteristics. Honeycomb seals are expensive because the manufacturing process is complex. Hole pattern seals are easier to manufacture, but they are still expensive. Use of a scallop pattern is one way to reduce manufacturing cost and time. A new seal that has a scallop pattern and small teeth on the stator surface is proposed. This pattern is cut on the stator surface using a disk type tool. To estimate the rotordynamic coefficients of this new seal, a bulk flow model code that is based on a two-control-volume model developed by Matsuda for labyrinth seals was newly developed. This model uses the Hirs model for the viscous shear stresses. The friction factor coefficients for the rotor surface, the stator surface, and the surface between the two-control-volumes were determined by computational fluid dynamics (CFD) steady analysis. The rotordynamic coefficients can also be obtained by using CFD perturbation analysis. The high accuracy of the bulk flow model was demonstrated by comparing its results with CFD perturbation analysis results. In the perturbation analysis, the whirling motion was treated as a steady-state problem by using a rotating frame of reference. For the damper seal, the rotor surface and its neighboring region were treated with a rotating frame of reference and the neighboring region of the stator was treated with a stationary frame of reference. The damping property of the new seal was evaluated by conducting rotor stability tests using a high-pressure compressor with an electromagnetic exciter. The new seal equipped with swirl brakes was used for the balance piston of the compressor. Stability was evaluated by exciting the rotor during operation and identifying the eigenvalues of the rotor. The experimental results showed that the new seal increases damping. Comparison of the damping effect with calculations based on the bulk flow analysis showed good agreement.
Prediction of proximal advanced neoplasia: a comparison of four existing sigmoidoscopy-based strategies in a Chinese population (2014)

The US criteria had the highest sensitivity for detection of APN and lowest NNS and the UK score had the highest specificity and the lowest NNR. The performance of all these four criteria to predict APN is limited, highlighting an urgent need to devise a novel APN prediction system for Asian subjects.
Outdoor Experiments on 5G Radio Access Using BS and UE Beamforming in 28-GHz Frequency Band (2019)

This paper presents outdoor field experimental results in the 28-GHz frequency band of a 5G radio access system where base stations (BSs) are installed on buildings to deploy a 5G trial area in the Tokyo Odaiba waterfront area. This is an early field trial assessment of key 5G features such as BS and mobile station (MS) beam tracking, being deployed in dense urban areas. In the trial area, a variety of key 5G technologies and conditions are evaluated such as BS and MS massive multiple-input multiple-output (MIMO) antennas, beamforming and tracking, use of the high 28-GHz frequency, the wide frequency bandwidth of 400 MHz, intra-baseband unit (BBU) hand over (HO), and a coverage area in a realistic urban deployment with four different trial courses. Experimental results show that throughput exceeding 1 Gbps is achieved in the experiment area, and approximately 200 Mbps is achieved at 500 m away from the BS. We confirm that beam tracking and intra-BBU HO operate effectively while compensating for high path loss in the 28-GHz band to achieve a coverage area of 500 m. On the other hand, line of sight (LoS) and Non-LoS conditions are critical to 5G performance in the 28-GHz band, and we find that 5G connections may drop behind trees, buildings, and/or under a footbridge. The trial results show that the downlink throughput exceeds 50 Mbps in 85%, 50%, 70%, and 33% of the four different trial courses, respectively.