gebhart/patrepeval huggingface dataset:
Preoperative Planning for Reverse Shoulder Arthroplasty: Does the Clinical Range of Motion Match the Planned 3D Humeral Displacement? (2023)

Excessive humeral distalization seems to be detrimental to joint mobility, especially shoulder flexion. Humeral lateralization and humeral anteriorization measured using the ACP seem to promote better shoulder range of motion, with no threshold effect. These findings could be evidence of tension in the soft tissues around the shoulder joint, which should be taken into consideration during preoperative planning.
Microfabricated Optically Pumped Gradiometer with Uniform Buffer Gases (2021)

This paper reports on the development of a microfabricated gradiometer that permits uniform buffer gas content in both magnetometers. This improves the common mode noise rejection of the gradiometer by ensuring the broadening and shift of the Rb optical absorption line are uniform. The reported fabrication process permits micro-channels connecting the two magnetometers allowing for uniform buffer gas pressure. We discuss two methods of characterizing the common mode rejection ratio (CMRR), before and after measuring the frequency response of the individual magnetometers. The average uncalibrated and calibrated CMRR achieved in a table-top setup was 72.7 and 85.0 respectively over a bandwidth 3-200Hz.
Stretchable Photonic Crystal Cavity with Wide Frequency Tunability (2012)

We report a new approach for realizing a flexible photonic crystal (PC) cavity that enables wide-range tuning of its resonance frequency. Our PC cavity consists of a regular array of silicon nanowires embedded in a polydimethylsiloxane (PDMS) matrix and exhibits a cavity resonance in the telecommunication band that can be reversibly tuned over 60 nm via mechanical stretching-a record for two-dimensional (2D) PC structures. These mechanically reconfigurable devices could find potential applications in integrated photonics, sensing in biological systems, and smart materials.
Specialized proresolution mediators enhance human B cell differentiation to antibody secreting cells (53.10) (2012)

Abstract The resolution of inflammation is an active and dynamic process critical in maintaining homeostasis. Newly identified lipid-derived mediators are key players during the process of inflammation resolution. These specialized proresolution mediators (SPM) constitute separate classes of compounds, which include lipoxins, resolvins, protectins and maresins, all derived from essential fatty acids. SPM regulate aspects of the immune response, including inhibition of neutrophil infiltration, reduction of T cell cytokine production and stimulation of macrophage phagocytic activity. However, their effects on B lymphocytes are unknown. Our study shows that the novel SPM 17-hydroxydosahexaenoic acid (17-HDHA), resolvin D1 (RvD1) but not protectin D1 (PD1), strongly increase the ability of normal human B cells to produce IgM and IgG. The increased antibody levels are due to an increased number of antibody-secreting cells. Furthermore, SPM regulate the expression of the transcription factors Blimp-1, Xbp-1 and Pax-5, and promote B cell differentiation towards a CD27+CD38+ antibody secreting cell phenotype. None of the SPM affect proliferation and are non-toxic. The increase in plasma cell differentiation and antibody production coincides with the known involvement of SPM during the late stages of inflammation and pathogen clearance. These new findings highlight the potential applications of SPM as endogenous and non-toxic adjuvants and anti-inflammatory therapeutic molecules.
Maternal hair selenium levels as a possible long-term nutritional indicator of recurrent pregnancy loss (2013)

While there were significant differences in the 2 groups with regard to resources, education and diet our results show that hair selenium concentrations and dietary selenium intake, were similar in the two groups. Both groups had low levels of this important element.
Kernel principal angles for classification machines with applications to image sequence interpretation (2003)

We consider the problem of learning with instances defined over a space of sets of vectors. We derive a new positive definite kernel f(A, B) defined over pairs of matrices A, B based on the concept of principal angles between two linear subspaces. We show that the principal angles can be recovered using only inner-products between pairs of column vectors of the input matrices thereby allowing the original column vectors of A, B to be mapped onto arbitrarily high-dimensional feature spaces. We apply this technique to inference over image sequences applications of face recognition and irregular motion trajectory detection.
Observation of theχb1(3P)andχb2(3P)and Measurement of their Masses (2018)

The χ_{b1}(3P) and χ_{b2}(3P) states are observed through their ϒ(3S)γ decays, using an event sample of proton-proton collisions collected by the CMS experiment at the CERN LHC. The data were collected at a center-of-mass energy of 13 TeV and correspond to an integrated luminosity of 80.0 fb^{-1}. The ϒ(3S) mesons are identified through their dimuon decay channel, while the low-energy photons are detected after converting to e^{+}e^{-} pairs in the silicon tracker, leading to a χ_{b}(3P) mass resolution of 2.2 MeV. This is the first time that the J=1 and 2 states are well resolved and their masses individually measured: 10513.42±0.41(stat)±0.18(syst) MeV and 10524.02±0.57(stat)±0.18(syst) MeV; they are determined with respect to the world-average value of the ϒ(3S) mass, which has an uncertainty of 0.5 MeV. The mass splitting is measured to be 10.60±0.64(stat)±0.17(syst) MeV.
Characterization of cDNA clones for human myeloperoxidase: Predicted amino acid sequence and evidence for multiple mRNA species (1987)

Myeloperoxidase is a component of the microbicidal network of polymorphonuclear leukocytes. The enzyme is a tetramer consisting of two heavy and two light subunits. A large proportion of humans demonstrate genetic deficiencies in the production of myeloperoxidase. As a first step in analyzing these deficiencies in more detail, we have isolated cDNA clones for myeloperoxidase from an expression library of the HL-60 human promyelocytic leukemia cell line. Two overlapping plasmids (pMP02 and pMP062) were identified as myeloperoxidase cDNA clones based on the detection with myeloperoxidase antiserum of 70 kDa protein expressed in pMP02-containing bacteria and a 75 kDa polypeptide produced by hybridization selection and translation using pMP062 and HL-60 RNA. Formal identification of the clones was made by matching the predicted amino acid sequences with the amino terminal sequences of the heavy and light subunits. Both subunits are encoded by one mRNA in the following order: pre-pro-sequences--light subunit--heavy subunit. The molecular weight of the predicted primary translation product is 83.7 kDa. Northern blots reveal two size classes of hybridizing RNAs (approximately 3.0-3.3 and 3.5-4.0 kilobases) whose expression is restricted to cells of the granulocytic lineage and parallels the changes in enzymatic activity observed during differentiation.
Cuff-pressure induced PAT changes — modelling and experimental verification towards calibration of blood pressure surrogates (2016)

Arterial Blood Pressure (ABP) is one of the most often measured vital parameters in daily clinical practice. State-of-the-Art non-invasive ABP measurement technologies have obvious limitations and are still mainly based on uncomfortable techniques by complete or partial occlusions of arteries. Additionally, embodiments are bulky, difficult to apply for the layman, or provide only intermittent measurements. We have been investigating the pulse arrival time (PAT) and pulse transit time (PTT) methodology for unobtrusive blood pressure (BP) measurements. However, BP surrogates like PAT or PTT require a calibration step, which is currently an unresolved problem. In this paper we report on our investigations using cuff-pressure induced PAT changes in order to provide insights in the BP-PAT sensitivities for subjects at rest.
Intra- And Inter-Scanner Variability of Magnetization Transfer Ratio Using Balanced SSFP (2009)

Magnetization transfer ratio (MTR) has become an important tool to study various tissue abnormalities, such as demyelination in brain white matter. Recently, a new technique for measuring MTR has been proposed based on balanced steady-state free precession (bSSFP) with modified radiofrequency pulses. The reproducibility and variability of MTR-bSSFP was analyzed on six healthy volunteers using two different 1.5T clinical systems. Intra-scanner MTR measurements were well reproducible (&lt; ±0.3 pu) and inter-scanner variation is below 0.5 pu for optimal flip angle settings ([pu]: percentage units). MTR-bSSFP benefits further from relatively low B1 sensitivity, high signal-to-noise ratios, and short overall acquisition times.
Abstract 19355: BET Bromodomain Proteins Are Critical Regulators of Molecular Reprogramming in Genetic Dilated Cardiomyopathy (2017)

Pathologic gene expression is a hallmark of DCM. Mice carrying a human DCM mutation in phospholamban (PLNR9C) develop fibrosis, DCM and premature death. Temporal RNAseq and pathway analysis in PLNR...
Robotic snow cat (2000)

In recent years, break-through in GPS-navigation has 
led to a whole new range of robotic control applications. 
The Stanford University GPS laboratory has pioneered 
research in fields ranging from unmanned aerial vehicles, 
robotic open-pit mining trucks, and autonomous farm 
tractors. This same technology can also find use in 
grooming the slopes of a ski area! With safety paramount, snow grooming is always 
performed after closing time of a ski resort, i.e. evenings 
and nights. Robotic snow cats have great promise for 
reducing current operating costs of snow grooming, partly 
due to cost of operators working extremely odd hours of 
the day. With a state-of-the-art navigation system, one 
may operate even in full whiteout conditions. 
Furthermore, a robotic vehicle could be more readily used 
in avalanche prone areas. From the standpoint of a manufacturer, an autonomous 
snow cat has no need for an operator cabin (w/ chairs, 
controls, radios/CD-players etc.). Removing that cabin 
may well save weight as well as cost of production. 
Finally, cabin removal will open new degrees of freedom 
in snow cat design. A lower snow cat would be more 
stable, and it could more easily access areas under lifts. As a first step towards the ultimate goal, a GPS-based 
autopilot for a Bombardier MP Plus snow cat has been 
implemented and tested. This paper gives a general 
system overview and presents results from field tests at 
Alpine Meadows Ski Resort. All tests were performed 
without any attitude system, but the results still show total 
system errors in the 10-cm range.
Modal Identification for Integrally Bladed Rotors Under Traveling Wave Excitation (2022)

Abstract The safety of a fielded integrally bladed rotor (IBR) is often assessed through vibration testing. Responses due to various types of excitation are measured and processed and can be inputs to follow-on analyses, such as mistuning identification. One such excitation technique is the traveling wave excitation (TWE) where all blades are simultaneously excited at phase differences that attempt to replicate naturally occurring mode shapes and certain operating conditions. This test relies on noncontact exciters, e.g., magnets and speakers, that are often not directly measured. As a result, formulating the frequency response function (FRF) is difficult and the extraction of system modal data using FRF fitting techniques in the absence of FRFs is not possible. This paper presents an approach to use measured responses from TWE tests. It is shown that the fast Fourier transform (FFT) of the TWE inputs is mostly independent over the prescribed frequency range. Consequently, the output spectral density matrix can be formulated in an operational modal analysis (OMA) sense, where direct measurement of the inputs is not needed. A full spectral density matrix is then formulated from a single measurement on each blade obtained during a single test, thus reducing the number of measurement locations and testing excitation conditions. This matrix is fit by a polyreference-least squares complex frequency-domain (P-LSCF) system identification technique tailored for OMA-type measurements. The methodology is tested using simulated TWE data for an IBR model using different damping levels. Comparisons between identified modal data and those used to create the model are made and show the methodology accurately predicts underlying system information even for closely spaced modes that are common to IBRs. Finally, the method is used on experimental TWE data of an industrial IBR.
Structural aspects of therapeutic enzymes to treat metabolic disorders (2009)

Protein therapeutics represents a niche subset of pharmacological agents that is rapidly gaining importance in medicine. In addition to the exceptional specificity that is characteristic of protein therapeutics, several classes of proteins have also been effectively utilized for treatment of conditions that would otherwise lack effective pharmacotherapeutic options. A particularly striking class of protein therapeutics is exogenous enzymes administered for replacement therapy in patients afflicted with metabolic disorders. To date, at least 11 enzymes have either been approved for use, or are in clinical trials for the treatment of selected inherited metabolic disorders. With the recent advancement in structural biology, a significantly larger amount of structural information for several of these enzymes is now available. This article is an overview of the correlation between structural perturbations of these enzymes with the clinical presentation of the respective metabolic conditions, as well as a discussion of the relevant structural modification strategies engaged in improving these enzymes for replacement therapies.
Contribution of proteasome-catalyzed peptidecis-splicing to viral targeting by CD8+T cells in HIV-1 infection (2019)

Peptides generated by proteasome-catalyzed splicing of noncontiguous amino acid sequences have been shown to constitute a source of nontemplated human leukocyte antigen class I (HLA-I) epitopes, but their role in pathogen-specific immunity remains unknown. CD8<sup>+</sup> T cells are key mediators of HIV type 1 (HIV-1) control, and identification of novel epitopes to enhance targeting of infected cells is a priority for prophylactic and therapeutic strategies. To explore the contribution of proteasome-catalyzed peptide splicing (PCPS) to HIV-1 epitope generation, we developed a broadly applicable mass spectrometry-based discovery workflow that we employed to identify spliced HLA-I-bound peptides on HIV-infected cells. We demonstrate that HIV-1-derived spliced peptides comprise a relatively minor component of the HLA-I-bound viral immunopeptidome. Although spliced HIV-1 peptides may elicit CD8<sup>+</sup> T cell responses relatively infrequently during infection, CD8<sup>+</sup> T cells primed by partially overlapping contiguous epitopes in HIV-infected individuals were able to cross-recognize spliced viral peptides, suggesting a potential role for PCPS in restricting HIV-1 escape pathways. Vaccine-mediated priming of responses to spliced HIV-1 epitopes could thus provide a novel means of exploiting epitope targets typically underutilized during natural infection.
Synthetic metallic dialkyldithiocarbamates as antiwear and extreme-pressure additives for lubricating oils : role of metal on their effectiveness (1995)

Dialkydithiocarbamates of five metals have been synthesized in pure form by following a simple general method. The alkyl chain in each of these compounds has been kept the same so as to observe the performance variations due to metal ions. The EP properties expressed as load wear index and weld load indicated the highest performance by Bi followed by Pb, Sb, Zn and Mo. The antiwear properties in terms of wear scar diameter, relative anti-wear effectiveness and mean average wear scar diameter show a performance order of Bi > Pb > Sb > Zn > Mo. The large ionic radius metals (Bi, Pb & Sb) had the best overall load-carrying performance and their effectiveness increased substantially when the additive concentration was more than 0.004 gm atom/Kg. The results suggest that Bi has good potential to replace toxic Pb and Sb from existing lubrication systems. 18 refs., 7 refs., 1 tab.
Signal transduction properties of the T cell activation monoclonal antibody panel: ubiquitous increase in cellular substrate tyrosine phosphorylation in the absence of detectable calcium mobilization (1996)

A panel of coded monoclonal antibodies (mAbs) submitted to the T cell section of the Vth International Workshop and Conference on Human Leukocyte Differentiation Antigens was examined for the ability to induce cellular activation. Intracellular calcium levels were examined by loading resting T cells with the Ca(+2)-specific dye Indo-1, incubating the cells with Ab, cross-linking with goat anti-mouse Ab and analyzing by flow cytometry. Only 11 out of 68 Abs induced a detectable rise in Ca+2; two of these Abs induced a substantial rise in Ca+2. In resting T cells, 63 of 68 Abs induced increased tyrosine phosphorylation of substrates compared to negative control. Approximately half of the Abs that induced tyrosine phosphorylation induced substrates different from those seen following treatment of cells with anti-CD3 Ab. All mAbs that induced a rise in Ca+2 also induced increased tyrosine phosphorylation. These experiments show a distinct difference in the ability of cross-linked Ab to induce changes in tyrosine phosphorylation and intracellular free Ca+. Furthermore, these results indicate that transient increases in cellular substrate phosphorylation may have questionable biologic significance in T cells.
Fabrication of Feedthrough Atom Trapping Chips for Atomic Optics (2007)

We present a novel fabrication process for feedthrough atom trapping chips, which are used in atomic condensate optics. Copper electroplating is employed to vacuum seal the chip-through vias. The advantages of using feedthrough atom trapping chips are the simple microfabrication process and reduction of the overall chip area bonded to the glass atom trapping cell. The results demonstrate that current can be conducted through the vias while the vacuum can also be held under 1×10-9 torr.
Capacity of space-time block codes in MIMO Rayleigh fading channels with adaptive transmission and estimation errors (2005)

Orthogonal space-time block coding (STBC) has recently raised a lot of research interest due to its inherent mathematical feature that enables simple linear decoding at the receiver and provides full diversity over the multiple-input multiple-output (MIMO) fading channel. In this paper, we derive general closed-form expressions for the Shannon capacity achieved by this transmit-diversity scheme over Rayleigh fading channels under adaptive transmission and channel-estimation errors. Adaptive transmission can be performed on a frame-by-frame basis, provided that a channel state information (CSI), consisting of the signal-to-noise ratio (SNR) level as estimated by the receiver, is fed back to the transmitter, thereby allowing for different compromises between the achievable capacity and the corresponding implementation complexity. The closed-form capacity formulas, derived for different power- and rate-allocation policies, are expressed in terms of the number of transmit and receive antennas, the code rate of the STBC mapping, and a single parameter capturing Gaussian channel-estimation errors. Numerical results showing the effects of these parameters on the capacity of STBC subject to the adaptive-transmission policies under consideration are provided.
Integrated Fiber-Wireless System in W Band for Ultra-Dense Small-Cell and Moving-Cell Network (2019)

We present a high-speed integrated fiber-wireless system in the W band for transmission of high- frequency radio signals to ultra-dense small cells and moving cells. The system utilizes a wavelength-division-multiplexing intermediate- frequency-over-fiber system and a remote generation and transmission of local oscillator signals. We experimentally confirmed satisfactory performance for the transmission of 4 Ã- 25-Gb/s and 20-Gb/s OFDM signals over a fixed and a switchable system, respectively. The system is highly spectral efficiency and scalable for signal transmission in future mobile networks.
Draco (2014)

Draco [4] is a sketch-based interface that allows artists and casual users alike to add a rich set of animation effects to their drawings, seemingly bringing illustrations to life. While previous systems have introduced sketch-based animations for individual objects, our contribution is a unified framework of motion controls that allows users to seamlessly add coordinated motions to object collections. We propose a framework built around kinetic textures, which provide continuous animation effects while preserving the unique timeless nature of still illustrations. This enables many dynamic effects difficult or not possible with previous sketch-based tools, such as a school of fish swimming, tree leaves blowing in the wind, or water rippling in a pond. A user study with professional animators and casual users demonstrates the variety of animations, applications and creative possibilities our tool provides.
ChemInform Abstract: Carpe Diubiquitin (2011)

Abstract Review: 15 refs.
What is memory? The present state of the engram (2016)

The mechanism of memory remains one of the great unsolved problems of biology. Grappling with the question more than a hundred years ago, the German zoologist Richard Semon formulated the concept of the engram, lasting connections in the brain that result from simultaneous "excitations", whose precise physical nature and consequences were out of reach of the biology of his day. Neuroscientists now have the knowledge and tools to tackle this question, however, and this Forum brings together leading contemporary views on the mechanisms of memory and what the engram means today.
The Design of Planar and Rolled Fat Monopole Antenna for UWB Radio System (2006)

In this paper, we proposed two types of antennas, planar fat monopole antenna and rolled fat monopole antenna for UWB system. The rolled fat monopole antenna is designed to reduce the size of the planar fat monopole antenna and two antennas are compared. The proposed antennas have the omni-directional pattern in azimuth. They satisfy 3.1 GHz/spl sim/7.8 band GHz for VSWR <2, using the tapered radiator and partial ground plane.
Performance of a Liquid Lens Enabled Optical Coherence Microscope with Gabor Fusion (2010)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. P. Rolland, S. Murali, P. Meemon, P. Glenn, K. P. Thompson, and K. Lee, "Performance of a Liquid Lens Enabled Optical Coherence Microscope with Gabor Fusion," in International Optical Design Conference and Optical Fabrication and Testing , OSA Technical Digest (CD) (Optica Publishing Group, 2010), paper IWD4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article