gebhart/patrepeval huggingface dataset:
Additive manufacturing: modular platform for 3D printing fluid-containing monoliths (2022)

Fluid-filled capsules and liquidous polymers are combined to produce 3D printable inks, enabling printing of fluid-containing monoliths with porous and nonporous microstructures.
An electrically driven membrane microdisk laser for the integration of photonic and electronic ICs (2005)

Abstract — We report on electrically pumped lasing in a microdisk cavity in an InP-based membrane bonded on top of a silicon wafer. The top metal contact is placed in the center of the disk, whereas the bottom contacting is done by means of a thin lateral contacting layer. In order to avoid large optical absorption in p-type contact layers, a tunnel junction was used in combination with two n-type contacts. Lasing was observed in pulsed regime with a current threshold of about 1.5mA, for microdisks with a diameter of 8µm.
Genome Scale Identification ofTreponema pallidumAntigens (2005)

Antibody responses for 882 of the 1,039 proteins in the proteome of Treponema pallidum were examined. Sera collected from infected rabbits were used to systematically identify 106 antigenic proteins, including 22 previously identified antigens and 84 novel antigens. Additionally, sera collected from rabbits throughout the course of infection demonstrated a progression in the breadth and intensity of humoral immunoreactivity against a representative panel of T. pallidum antigens.
Synthesis of Functionalized 2′,5‐Oxo‐spiro[furan‐2,3′‐indoline]‐3‐carboxylate Derivatives as Antiproliferative Agents: ADMET Studies, and Molecular Docking against P2Y12 Inhibitors (2023)

Abstract Herein, we present a one‐pot, three‐component synthesis of spirooxindole‐oxofuran carboxylate derivatives ( 4 a – d ) through the Huisgen reaction. The newly synthesized spirocyclic compounds were tested for in vitro antiproliferative efficacy against 60 human cancer cell lines at the National Cancer Institute (NCI) in the United States. The screening results indicated that two spirooxindole compounds, 4 b and 4 c , possessed the strongest anti‐cancer efficacy in terms of percentage growth inhibition (% GI), with values of 34.17 and 38.19 at 10 −5 M concentration against the CNS cancer panel‘s SNB‐75 cell line, respectively. Furthermore, molecular docking investigations demonstrated the binding affinity for the P2Y12 receptor. The compound 4 c which exhibited strong antiproliferative activity with high binding energies might therefore, serve as a potential lead molecule for the development of more effective anti‐cancer agents.
Small-Molecule Suppressors of Cytokine-Induced β-Cell Apoptosis (2010)

Pancreatic beta-cell apoptosis is a critical event during the development of type-1 diabetes. The identification of small molecules capable of preventing cytokine-induced apoptosis could lead to avenues for therapeutic intervention. We developed a set of phenotypic cell-based assays designed to identify such small-molecule suppressors. Rat INS-1E cells were simultaneously treated with a cocktail of inflammatory cytokines and a collection of 2,240 diverse small molecules and screened using an assay for cellular ATP levels. Forty-nine top-scoring compounds included glucocorticoids, several pyrazole derivatives, and known inhibitors of glycogen synthase kinase-3beta. Two compounds were able to increase cellular ATP levels, reduce caspase-3 activity and nitrite production, and increase glucose-stimulated insulin secretion in the presence of cytokines. These results indicate that small molecules identified by this screening approach may protect beta cells from autoimmune attack and may be good candidates for therapeutic intervention in early stages of type-1 diabetes.
Démonstration d'un générateur de signaux arbitraires utilisant des séquences orthogonales à base de composants du commerce (2022)

National audience
Pr-doped mixed-halide glasses for 1300 nm amplification (1994)

The pump efficiency of Pr-doped fluorozirconate amplifiers at 1300 nm is limited by nonradiative decay. A Pr/sup 3+1/G <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> excited state lifetime of 322 μs has been obtained in a mixed-halide glass. This is 2.9 times longer than the lifetime in a fluorozirconate host. Numerical amplifier modeling combined with calculated emission cross sections predicts a comparable increase in amplifier pump efficiency. The mixed-halide <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> G <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> emission is peaked at 1310 nm.
Leveraging social software for social networking and community development at events (2009)

Professional networking is a primary goal of people attending conferences and events. Over the past year we have developed an online social networking and community tool for events, Pathable, to help attendees meet the right people. Pathable provides an online directory of attendee profiles, communication tools, and a recommendation system optimized to help people find each other based on commonalities. We performed a questionnaire study at a pathable-enabled event to assess the importance of social networking, and found that quality of conversations and sense of community were strong predictors of who said they would return year after year. In addition, the more people used Pathable to meet others at the event, the greater their event attachment and sense of community. Based on lessons learned from an overview of seventeen Pathable-enabled events, we provide guidelines for leveraging social software to optimize professional networking and community development at events.
Hard Gelatin and Hypromellose (HPMC) Capsules: Estimation of Rupture Time by Real-time Dissolution Spectroscopy (2006)

The objective of this study was to measure rupture time of gelatin and hypromellose (hydroxypropyl methylcellulose or HPMC) capsules using a novel approach based on real-time dissolution spectroscopy. Rupture time was measured in standard dissolution apparatus at a constant temperature using a dip-type fiber-optic probe. Labrasol released from the capsules was treated as the marker of the rupture process. Light scatter generated by the emulsified labrasol was detected by an ultrafast monochromator at scan rates approximating 24,000 nm/min. This technique was validated by measuring the dissolution time of gelatin capsules. Rupture times of hypromellose capsules were studied as a function of capsule size, capsule grade, and dissolution medium. Statistical correlations were analyzed by ANOVA. Rupture time of hypromellose capsules was dependent on both the medium and the grade of the capsule, and was independent of capsule size. The composition of the dissolution medium contributes to the rupture time of the capsules and should be considered when fast release and quick biological response is desired. Release delay, however, may not manifest itself in vivo and the time to maximum plasma concentration may not be significant.
Animal models of skin disease for drug discovery (2013)

Inflammatory and autoimmune skin diseases are all represented by a range of mouse models both transgenic and normal. Skin cancer is mainly studied in mice and fish. Wound healing is studied in a wider range of animal species, and skin infections such as acne and leprosy also have been studied in animal models. Moving to the more consumer-oriented area of dermatology, there are models for studying the harmful effect of sunlight on the skin, and testing of sunscreens, and several different animal models of hair loss or alopecia.
Nonflammable perfluoropolyether-based electrolytes for lithium batteries (2014)

The flammability of conventional alkyl carbonate electrolytes hinders the integration of large-scale lithium-ion batteries in transportation and grid storage applications. In this study, we have prepared a unique nonflammable electrolyte composed of low molecular weight perfluoropolyethers and bis(trifluoromethane)sulfonimide lithium salt. These electrolytes exhibit thermal stability beyond 200 °C and a remarkably high transference number of at least 0.91 (more than double that of conventional electrolytes). Li/LiNi1/3Co1/3Mn1/3O2 cells made with this electrolyte show good performance in galvanostatic cycling, confirming their potential as rechargeable lithium batteries with enhanced safety and longevity.
Abstract LB-132: The central role of EED in orchestration of polycomb group complexes (2014)

Abstract Polycomb Group (PcG) proteins play a vital role in establishing and maintaining gene expression patterns during cellular differentiation and development. They are epigenetic regulators that are responsible for the repression of target genes involved in development and cell fate specification. PcG proteins function as multimeric, chromatin-associated protein complexes. In mammals, there are two major Polycomb Repressive Complexes, PRC1 and PRC2 that possess histone-modifying activity crucial for their role in gene repression through methylation of histone H3K27, as well as the mono-ubiquitination of histone H2AK119. Components of both PRC1 and PRC2 have been shown to be elevated in a number of tumor types and play an important role in neoplastic progression. Major components of human PRC2 include the histone methyltransferase, Enhancer of Zeste Homolog 2, and its known binding partners, Embryonic Ectoderm Development (EED) and Suppressor of Zeste 12 (SUZ12) that collectively function as a multi-subunit complex trimethylating histone H3K27. Fundamental collaborators of PRC2 in epigenetic silencing include human PRC1 which consists of B lymphoma Mo-MLV insertion region 1 (BMI1), RING1A (also known as RING1), and RING1B (also known as RING2 or RNF2). Together, they function as a multi-protein complex to ubiquitinate histone H2A at lysine 119 (uH2A). The leading hypothesis regarding PRC2 and PRC1 interaction is that PRC2-mediated tri-methylation of H3K27 recruits PRC1 to genomic loci leading to chromatin condensation and epigenetic silencing of target genes. While the evidence linking PRC1 and PRC2 is circumstantial, a physical or molecular link between these complexes has not been established. In this study, we make an unexpected observation that EED, previously considered a critical component of PRC2, is instead a shared component of PRC2 and PRC1 that functions to interchange these epigenetic complexes at sites of histone modification. This observation markedly enhances our understanding of how PRC2 and PRC1 coordinate epigenetic regulation and may have implications in therapeutically targeting these master regulators of transcription. Citation Format: Qi Cao, Xiaoju Wang, Meng Zhao, Rendong Yang, Rohit Malik, Yuanyuan Qiao, Anton Poliakov, Xuhong Cao, Clair Harris, Felix Y. Feng, Sundeep Kalantry, Zhaohui Qin, Saravana M. Dhanasekaran, Arul M. Chinnaiyan. The central role of EED in orchestration of polycomb group complexes. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-132. doi:10.1158/1538-7445.AM2014-LB-132
Naturally variant autosomal and sex-linked loci determine the severity of iron overload in β2-microglobulin-deficient mice (2001)

Hereditary hemochromatosis (HH) is a common chronic human genetic disorder whose hallmark is systemic iron overload. Homozygosity for a mutation in the MHC class I heavy chain paralogue gene HFE has been found to be a primary cause of HH. However, many individuals homozygous for the defective allele of HFE do not develop iron overload, raising the possibility that genetic variation in modifier loci contributes to the HH phenotype. Mice deficient in the product of the beta(2)-microglobulin (beta(2)M) class I light chain fail to express HFE and other MHC class I family proteins, and they have been found to manifest many characteristics of the HH phenotype. To determine whether natural genetic variation plays a role in controlling iron overload, we performed classical genetic analysis of the iron-loading phenotype in beta(2)M-deficient mice in the context of different genetic backgrounds. Strain background was found to be a major determinant in iron loading. Sex played a role that was less than that of strain background but still significant. Resistance and susceptibility to iron overload segregated as complex genetic traits in F(1) and back-cross progeny. These results suggest the existence of naturally variant autosomal and Y chromosome-linked modifier loci that, in the context of mice genetically predisposed by virtue of a beta(2)M deficiency, can profoundly influence the severity of iron loading. These results thus provide a genetic explanation for some of the variability of the HH phenotype.
Eliciting and Annotating Uncertainty in Spoken Language (2014)

A major challenge in the ﬁeld of automatic recognition of emotion and affect in speech is the subjective nature of affect labels. The most common approach to acquiring affect labels is to ask a panel of listeners to rate a corpus of spoken utterances along one or more dimensions of interest. For applications ranging from educational technology to voice search to dictation, a speaker’s level of certainty is a primary dimension of interest. In such applications, we would like to know the speaker’s actual level of certainty, but past research has only revealed listeners’ perception of the speaker’s level of certainty. In this paper, we present a method for eliciting spoken utterances using stimuli that we design such that they have a quantitative, crowdsourced legibility score. While we cannot control a speaker’s actual internal level of certainty, the use of these stimuli provides a better estimate of internal certainty compared to existing speech corpora. The Harvard Uncertainty Speech Corpus, containing speech data, certainty annotations, and prosodic features, is made available to the research community.
Transvenous Approaches to the Vertebral‐Venous Plexus for Endovascular Treatment of Cervical Epidural Arteriovenous Fistulas: Anatomy and Technique (2022)

Accessing the cervical epidural venous space is technically demanding and requires effective planning and knowledge of relevant spinal venous anatomy. These techniques are important tools for safe and effective endovascular treatment of seAVF.
Mass production of a 3D non-woven nanofabric with crystalline P3HT nanofibrils for organic solar cells (2013)

A strategy for the in line mass production of a three-dimensional (3D) non-woven nanofabric consisting of crystalline P3HT nanofibrils, created by in situ cooling of the transportation line to feed a P3HT solution for a coating tool, was introduced. The required cooling-temperature with respect to the feeding rate for the overall nanofibril creating process and the yield of the nanofibrils in solution with various organic solvents were determined. Considering the influence of a change in the temperature on the status of the precipitated nanofibrils until feeding it into the spray nozzle, the margin of the surviving nanofibrils at a certain temperature was also investigated. To verify the superiority of our strategy and present directions regarding its application to industry, arrays of organic solar cells based on a 3D non-woven nanofabric structure consisting of P3HT nanofibrils were designed and fabricated using our in situ process combined with a spray-coating system. As a result, through the in situ cooling process, a considerable solar energy harvesting efficiency near 4%, which is a state-of-the-art value in a bi-layer-based solar cell, was obtained.
MARCKS Is Necessary for Netrin-DCC Signaling and Corpus Callosum Formation (2018)

Axons of the corpus callosum (CC), the white matter tract that connects the left and right hemispheres of the brain, receive instruction from a number of chemoattractant and chemorepulsant cues during their initial navigation towards and across the midline. While it has long been known that the CC is malformed in the absence of Myristoylated alanine-rich C-kinase substrate (MARCKS), evidence for a direct role of MARCKS in axon navigation has been lacking. Here, we show that MARCKS is necessary for Netrin-1 (NTN1) signaling through the DCC receptor, which is critical for axon guidance decisions. Marcks null (Marcks<sup>-/-</sup>) neurons fail to respond to exogenous NTN1 and are deficient in markers of DCC activation. Without MARCKS, the subcellular distributions of two critical mediators of NTN1-DCC signaling, the tyrosine kinases PTK2 and SRC, are disrupted. Together, this work establishes a novel role for MARCKS in axon dynamics and highlights the necessity of MARCKS as an organizer of DCC signaling at the membrane.
Detuning effect study of high-Q mobile phone antennas (2015)

Number of frequency bands that have to be covered by smart phones, are ever increasing. This broadband coverage can be obtained either by using a low-Q antenna or a high-Q tunable antenna. This study investigates high-Q antennas performance when placed in proximity of the user. This study is carried out through measurements, using Cellular Telecommunications Industry Association (CTIA) specified head and hand phantoms. The results of the high-Q antenna are, at low as well as high frequencies, compared to the results for a low-Q antenna. The results show that detuning of low-Q antennas is more severe compared to high-Q antennas. However, the drop in efficiency is comparable for both antennas in proximity of the user.
X-Ray Microscopy and Root Cause Analysis in Electronic Packaging (2015)

Abstract Advances in electronic packaging are fueled by the insatiable appetite that consumers have for bandwidth in mobile appliances. The technological answer to this demand is increase the interconnect count and shrink the pitch, solder volume and height. The features of interest and the defects in these packages are becoming increasingly smaller. Consequently, the characterization of these defects becomes more challenging due to the smaller size and new material structures. New package structures must pass the JEDEC standard tests and a critical part of qualifying new packages as products is proper identification of the root cause of failures. Therefore, innovative solutions to correct the fundamental problems in the development process enable new package solutions to be brought to the market. In this paper we describe an alternative failure analysis workflow involving X-ray microscopy which offers several advantages over standard imaging techniques. The nondestructive nature of x-ray microscopy enables engineers to image parts throughout the entire environmental stress cycle for more accurate determination of the root cause of failures. Additionally, a larger number of interconnects may be sampled, defect isolation in z direction for stacked die packages is made easier and subsequent imaging techniques may be used to complement the data. Both 3 dimensional images of defects as well as 2 dimensional cross sections will be shown to effectively analyze the true root cause of failures.
Yield-Modeling and Test Oriented Taxonomy of IC Structure Deformations (2003)

Abstract This paper proposes a taxonomy of process-induced deformations of IC structures. Such a taxonomy is envisioned as a foundation for yield modeling and development of test strategies, as well as, for design of ICs with redundancy. It is proposed to address the rapidly growing complexity of interaction between process-induced deformations of IC structures and steadily shrinking geometry of deep submicron ICs.
ChemInform Abstract: Polymer‐Assisted Asymmetric Reactions. Part 4. Polymer‐Bound Ephedrine, Its Use and Limitations in Supported LiAlH4 Reductions. (1987)

Abstract The hydride reagent (I) formed from LiAlH 4 , dimethylphenol, and polymer‐bound l‐ephedrine reduces acetophenone (II) enantioselectively to form (III).
Supplementary Tables S1-S2 from TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma (2023)

&lt;p&gt;Supplementary Table S1-S2.&lt;/p&gt;
Insertion of influenza M protein into the viral lipid bilayer and localization of site of insertion (1981)

Recent studies with isolated M protein from influenza virus have shown that the protein has a high affinity for lipid. The ability of M to partition into lipid vesicles merely by shaking vesicles and M together is suggestive evidence that the protein could be interacting with the lipid in the virus particle. A more direct analysis was carried our here to determine whether M is in contact with the viral lipid in situ, by using the photoactivatable hydrophobic probe, pyrenesulfonyl azide. Covalent linkage of this probe to M indicated that a segment of M residues with in the virus membrane in contact with the lipid bilayer. M inserted into lipid vesicles at two locations on the molecule. A major insertion into lipid occurred in the middle of the molecule where a large cluster of 20 hydrophobic and neutral amino acids occurs. A second insertion occurred approximately one fourth in from the amino terminus, where a smaller segment of 13 uncharged amino acids is found. Confirmation that M inserted into lipid at these locations came also from results with cyanogen bromide fragments of M. Of the 12 to 13 fragments produced, 3 specifically bound to lipid vesicles. These were the first, second, and third contiguous segments beginnings at the amino terminus and containing the two hydrophobic areas noted above.
2A2-J03 Modelling and Control of Two link mechanism Driven by Pneumatic Artificial Muscle Actuator(Mechanism and Control for Actuator) (2011)

Recently, research and development has focused on robots that work in place of people. It is necessary for robots to perform the same flexible motions as people. Additionally, such robots need to incorporate high-level safety features. Here, we present artificial muscle-type pneumatic actuators as the driving source of a robot hand that is both safe and flexible. We develop a low-pressure, low-volume pneumatic actuator for driving a robot hand. We develop a five-fingered robot hand with pneumatic actuators. Next, we make a 2-link arm that has two degrees of freedom using pneumatic actuators, and the models of actuator and 2-link arm is constructed. A control PID control system is constructed, and the gains of the PID control system are determined by the simulation that uses the model of 2-link arm. The step response of the joint angle is examined. Control performance of the PID control system is verified.
EFFECT OF β-1,3/1,6-D-GLUCAN ON THE PHAGOCYTIC ACTIVITY AND OXIDATIVE METABOLISM OF PERIPHERAL BLOOD GRANULOCYTES AND MONOCYTES IN RATS (2009)

The experiment was performed on 20 adult Wistar rats aged 12 weeks, divided into two equal groups (control and experimental), each comprised of five males and five females. From the first day of the experiment, the experimental group rats were fed Murigran feed supplemented with β-1,3/1,6-D-glucan at a dosage of 12-19 mg/rat/d, subject to body weight, while the controlgroup was administered the same feed without any additives. At the beginning of the experiment and then after 14 days, arterial blood samples were collected from the rats and diluted with heparin to measure and compare the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes by flow cytometry. Statistically higher levels of the activity were observed in the group of rats administered glucan than in controls, expressed in terms of the percentage of phagocytic cells as well as average fluorescence intensity. β-1,3/1,6-D-glucan also had a positive effect on the oxidative metabolism of both granulocytes and monocytes after stimulation with E. coli, and on the oxidative metabolism of granulocytes after stimulation with PMA.