gebhart/patrepeval huggingface dataset:
A CMOS image sensor for 10Mb/s 70m-range LED-based spatial optical communication (2010)

Spatial optical communication has recently been of interest in the mobile local-area communication systems, especially in the automotive applications. It has many advantages over the radio communication such as robustness to jamming, human safety due to lack of electromagnetic waves and sender finding function. The image sensor communication (ISC) technology is useful for the spatial optical communication because to find the light source and to intensify the light energy density at the receiver, the optical receiver has to have signal light source finding and tracking functions. A few approaches for the ISC have been reported. CMOS ISC chips have been used for ID beacon detection [1] [2], where very low data rate is required. In an ISC chip for optical wireless LAN application [3], the data rate of several hundreds of MHz has been demonstrated. In this approach, however, photo-diode current of a 2-D detector array directly flows into external receiver circuits, and because of this, extremely large optical power using laser lights is required. The authors have reported an ISC chip for LED-light communications [4]. In this chip, the bit rate of 1Mb/s and the communication range of a few meters only have been demonstrated. Though the chip claims the function of signal light source tracking, no experimental results have been shown. This paper presents a CMOS ISC chip which demonstrates that the high-speed long-distance spatial optical communication over 10Mb/s and 50meters are realized for the system using LED light sources while attaining signal-light finding and tracking functions. The key techniques to improve the data rate and tracking performance are a new pixel structure using depleted diode, pulse equalizing, and binary flag image readout to find the exact area of light source.
CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells (2015)

Identification and purification of cancer stem cells (CSCs) lead to the discovery of novel therapeutic targets; however, there has been no study on isolation of the CSC population among pancreatic neuroendocrine tumors (pNETs). This study aimed to identify pNET CSCs and to characterize a therapeutic candidate for pNET CSCs. We identified CSCs by aldehyde dehydrogenase (ALDH) activity in pNET clinical specimens and cell lines. We verified whether or not these cells have the stemness property in vivo and in vitro. ALDHhigh cells, but not control bulk cells, formed spheres, proliferated under hypoxic condition as well as normoxic condition and promoted cell motility, which are features of CSCs. Injection of as few as 10 ALDHhigh cells led to subcutaneous tumor formation, and 105 ALDHhigh cells, but not control bulk cells, established metastases in mice. Comprehensive gene expression analysis revealed that genes associated with mesenchymal stem cells, including CD73, were overexpressed in ALDHhigh cells. Additionally, the in vitro and in vivo effects of an inhibitor of CD73 were investigated. The CD73 inhibitor APCP significantly attenuated in vitro sphere formation and cell motility, as well as in vivo tumor growth observed for ALDHhigh cells. Finally, its expression was evaluated using clinical pNET tissue samples. Immunohistochemical analysis of clinical tissue samples demonstrated CD73 expression was significantly correlated with the invasion into adjacent organs. Since recent studies revealed CD73 as a potential biomarker of anti-PD-1 immune checkpoint therapy, CD73 might be a promising therapeutic target for pNET CSCs.
Energy and Spectral Efficiency Tradeoff in NOMA: Multi-Objective Evolutionary Approaches (2020)

Non-orthogonal multiple access (NOMA) deployment in future wireless networks has been recently considered a promising radio access technology to enhance spectral efficiency (SE). However, gain in SE comes always with the cost of energy efficiency (EE). In this paper, we investigate the SE and EE tradeoff in downlink NOMA with the consideration of quality of service (QoS) requirements based on three population-based multi-objective evolutionary algorithms (MOEAs): multi-objective particle swarm optimization (MOPSO), non-dominated sorting genetic algorithm-II (NSGA-II) and strength Pareto evolutionary algorithm-2 (SPEA2). The tradeoff is optimized and Pareto optimal solutions are obtained through MOEAs. The effectiveness of the algorithms is evaluated based on the hypervolume metric and the capability of solving multi-objective optimization problems. Simulation results reveal that SPEA2 outperforms NSGA-II and MOPSO. Furthermore, NSGA-II is the loser among all algorithms in terms of finding Pareto optimal results.
Reactivity-based one-pot total synthesis of fucose GM 1 oligosaccharide: A sialylated antigenic epitope of small-cell lung cancer (2003)

The total synthesis of the sialic acid-containing antigenic epitope fucose GM(1) (Fuc-GM(1)) by an improved reactivity-based one-pot synthetic strategy is reported. Based on a thioglycoside reactivity database, three saccharide building blocks, 3, 4, and 5, were designed and prepared to incorporate a descending order of reactivity toward thiophilic activation. Using the reactivity-based one-pot synthetic method, the fully protected Fuc-GM(1) glycoside 2 was furnished in a facile manner, which was globally deprotected to give the Fuc-GM(1) glycoside 1. In addition, using the promoter system 1-(benzensulfinyl)piperidinetrifluoromethanesulfonic anhydride, the product yield was improved and the reaction time was reduced in comparison with the N-iodosuccinimidetrifluoromethanesulfonic acid- and dimethyl (thiomethyl) sulfonium trifluoromethanesulfonate-promoted systems.
A cadaveric model to evaluate the effect of unloading the medial quadriceps on patellar tracking and patellofemoral joint pressure and stability (2018)

These findings provide basic scientific rationale to support the role of quadriceps strengthening to resist patellar lateral maltracking and rebalance the articular contact pressure away from the lateral facet in patients with normal patellofemoral joint anatomy.
Carbon Dioxide Sorption and Transport in Amorphous Poly(ethylene furanoate) (2015)

Transport properties of carbon dioxide in amorphous poly(ethylene furanoate) (PEF) were investigated using complementary pressure-decay sorption and permeation techniques. Detailed measurements for PEF at 35 °C indicate a significant, surprisingly large reduction in carbon dioxide permeability of 19× at 1 atm compared to poly(ethylene terephthalate) (PET), despite both an increase in free volume and carbon dioxide solubility of 1.6× for PEF vs PET. The solubility increase for PEF, which originates from greater interaction between carbon dioxide and the polar furan moiety, is offset by a substantial reduction in diffusivity of 31× compared to PET. Such diffusion reduction for PEF, which is 3× greater than the 9.7× reduction in oxygen diffusivity compared to PET, is thought to originate from a hindrance of polymer ring-flipping motions compared to PET. A possible mechanism for the surprising barrier improvement for carbon dioxide in PEF vs PET is explained herein along with a detailed comparison to oxygen and water transport.
A Pilot Study Assessing the User Benefit of Skin Photoprotectants Perceived by University of Arizona Pharmacy Students (2012)

Class of 2012 Abstract
Highly Optimized Nanocrystal-Based Split Gate Flash for High Performance and Low Power Microcontroller Applications (2011)

We show a 90nm nanocrystal-based split gate embedded flash memory that is able to meet the speed, endurance and reliability requirements for 32-bit microcontroller products. A 3.4V operating window is achievable and the process is robust and repeatable across many lots. Erase after 10k cycles can be achieved in 5ms, long-term data retention of cycled arrays is not susceptible to SILC-induced charge loss mechanisms, and program disturb can meet the needs of flash and EEPROM.
Comparison of Molecular Changes in Lung Cancers in HIV-Positive and HIV-Indeterminate Subjects (1998)

Microsatellite alterations, which reflect widespread genomic instability, occur at greatly increased frequency in HIV-associated lung carcinomas. Although the mechanism underlying the development of increased MAs is unknown, it may play a crucial role in the development of many HIV-associated tumors.
Secure off-path replication in content-centric networks (2017)

We present SCR, a secure content replication protocol for the Content-Centric Networking (CCN) architecture. The goal of SCR is to allow a data producer to cache protected content in off-path semi-trusted caches or replicas. In contrast to the standard “take what you want” model of CCN, SCR ensures that no unauthorized, off-path entity can obtain data from these replicas, even if the content is encrypted. SCR allows a producer to encrypt data under any viable access control scheme, such as group-based access backed by broadcast encryption, and delegate the delivery of said content to distributed replicas in the network. SCR is analogous to “blind caching” in IP-based networks, which aim to provide caching as a service in the presence of end-to-end encryption via TLS. We discuss the design details and security features, e.g., revocation, of SCR. We then compare SCR to the HTTP(S)-based blind caching model. We show that our scheme can outperform blind caching due to (1) less protocol complexity and message overhead, (2) faster session establishment, and (3) the ability to obtain data in parallel from multiple, independent replicas.
Field Emission of Electron Anions Clathrated in Subnanometer‐Sized Cages in [Ca24Al28O64]4+(4e–) (2004)

[Ca 24 Al 28 O 64 ] 4+ (4e – ) is a new inorganic electride, which is air‐stable even at ∼ 300 °C. Its electron field‐emission properties originate from electron anions encaged in subnanometer‐sized cages embedded in its crystal structure, and the emission current is controlled by Fowler–Nordheim field emission at high electric fields (see Figure). Field‐emission display devices demonstrate bright light emission clearly visible under ambient light (inset).
Polyamine polymers from active hydrogen compounds, formaldehyde, and amines (1974)

Abstract Active hydrogen compounds such as hydroquinone (HQ), cyclohexanone (CH), acetophenone (AP), and 4,4′‐methylene bis‐ N ‐methylaniline (MNA) polymerized with formaldehyde (F) and secondary diamines to produce Mannich base polyamine polymers. The HQ‐containing polymers were oxidized to benzoquinone (BQ)‐containing polymers and their redox properties were investigated in the desulfurization of hydrogen sulfide.
Simultaneous Drug Targeting of the Promoter MYC G-Quadruplex and BCL2 i-Motif in Diffuse Large B-Cell Lymphoma Delays Tumor Growth (2017)

Secondary DNA structures are uniquely poised as therapeutic targets due to their molecular switch function in turning gene expression on or off and scaffold-like properties for protein and small molecule interaction. Strategies to alter gene transcription through these structures thus far involve targeting single DNA conformations. Here we investigate the feasibility of simultaneously targeting different secondary DNA structures to modulate two key oncogenes, cellular-myelocytomatosis (MYC) and B-cell lymphoma gene-2 (BCL2), in diffuse large B-cell lymphoma (DLBCL). Cotreatment with previously identified ellipticine and pregnanol derivatives that recognize the MYC G-quadruplex and BCL2 i-motif promoter DNA structures lowered mRNA levels and subsequently enhanced sensitivity to a standard chemotherapy drug, cyclophosphamide, in DLBCL cell lines. In vivo repression of MYC and BCL2 in combination with cyclophosphamide also significantly slowed tumor growth in DLBCL xenograft mice. Our findings demonstrate concurrent targeting of different DNA secondary structures offers an effective, precise, medicine-based approach to directly impede transcription and overcome aberrant pathways in aggressive malignancies.
Silicon integrated dipole antennas on standard BiCMOS back end process for 40-80 GHz applications (2004)

International audience
Determination of technetium by reduction of methylene blue with tin(II) (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of technetium by reduction of methylene blue with tin(II)F. Grases and J. G. MarchCite this: Anal. Chem. 1985, 57, 7, 1419–1422Publication Date (Print):June 1, 1985Publication History Published online1 May 2002Published inissue 1 June 1985https://pubs.acs.org/doi/10.1021/ac00284a054https://doi.org/10.1021/ac00284a054research-articleACS PublicationsRequest reuse permissionsArticle Views96Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mathematical Modeling of Liquid‐Junction Photovoltaic Cells: III . Optimization of Cell Configurations (1984)

The liquid-junction photovoltaic cell is an electrochemical system with one or two semiconducting electrodes.This system provides a means of converting solar energy to chemical or electrical energy.A one-dimensional mathematical modei of the liquid-junction photovoltaic cell has been developed.The one-dimensional model of the liquid-junction cell was coupled with primary resistance calculations to predict the optimal performance of three cell configur'ations.Two cells are considered in which the semiconductor is illuminated from the electrolyte side and one in which the semiconductor is illuminated from the current-collector side.An economic analysis is presented based upon these results.The performance of the liquid-junction photovoltaic cell is dependent upon the design.surface area.and placement of the counterelectrode and current collectors.
Enhancement of light emission and internal quantum efficiency in orange and red regions for regularly arrayed InGaN/GaN nanocolumns due to surface plasmon coupling (2017)

We demonstrate enhanced light emission in the orange and red regions from regularly arrayed InGaN/GaN nanocolumns due to the surface plasmon (SP) coupling. A maximum photoluminescence (PL) enhancement ratio of 5.2 is observed by coating the nanocolumns with an Au thin film. In addition, a 2.1-fold increase in the internal quantum efficiency is obtained. Comparison of an electromagnetic field simulation and a theoretical calculation based on the SP dispersion indicates that the SP originates from a standing wave mode arising from the periodic Au/dielectric interface. The column-diameter dependence of the PL enhancement ratio can be reasonably explained by considering the simulated electric field intensity. The periodic plasmonic nanostructure is effective for improving the emission efficiencies of InGaN-based light emitters in the orange and red regions.
PARP Cleavage and Perturbance in Mitochondrial Membrane Potential by 3-α-Propionyloxy-β-Boswellic Acid Results in Cancer Cell Death and Tumor Regression in Murine Models (2012)

These findings demonstrate that acyl substituents/groups in the main skeleton of β-boswellic acid have the potential to be potent chemotherapeutic agents.
Predicting Individual Book Use for Off-Site Storage Using Decision Trees (1996)

We explore various methods for predicting library book use, as measured by circulation records. Accurate prediction is invaluable when choosing titles to be stored in an off-site location. Previous researchers in this area concluded that past-use information provides by far the most reliable predictor of future use. Because of the computerization of library data, it is now possible not only to reproduce these earlier experiments with a more substantial data set, but also to compare their algorithms with more sophisticated decision methods. We have found that while previous use is indeed an excellent predictor of future use, it can be improved on by combining previous-use information with bibliographic information in a technique that can be customized for individual collections. This has immediate application for libraries that are short on storage space and wish to identify low-demand titles to move to remote storage. For instance, simulations show that the best prediction method we develop, when used as the off-site storage selection method for the Harvard College Library, would have generated only a fifth as many off-site accesses as compared to a method based on previous use.
Expression, regulation, and function of P2X4purinergic receptor in human cervical epithelial cells (2002)

Micromolar concentrations of ATP stimulate biphasic change in transepithelial conductance across CaSki cultures on filters, an acute transient increase (phase I response; triggered by P2Y(2) receptor and mediated by calcium mobilization-dependent cell volume decrease) followed by a slower decrease in permeability (phase II response). Phase II response is mediated by augmented calcium influx and protein kinase C-dependent increase in tight junctional resistance. The objective of the study was to determine the role of P2X(4) receptor as a mediator of phase II response. Human cervical epithelial cells express P2X(4) receptor mRNA (1.4-, 2.2-, and 4.4-kb isoforms by Northern blot analysis) and P2X(4) protein. Depletion of vitamin A reversibly downregulated P2X(4) receptor mRNA and protein and ATP-induced calcium influx. Depletion of vitamin A abrogated phase II response, and the effect could be partially reversed only with retinoic acid receptor (RAR)-selective retinoids but not retinoid X receptor (RXR) agonists. Depletion of vitamin A also abrogated protein kinase C increase in tight junctional resistance, and the effect could not be reversed with retinoids. Depletion of vitamin A also abrogated phase I increase in permeability and reversibly downregulated P2Y(2) receptor mRNA and ATP-induced calcium mobilization. However, in contrast to phase II response, both RAR and RXR agonists could fully reverse those effects. These results suggest that phase II response is mediated by a P2X(4) receptor mechanism.
Influence of shock strength and timing on induction of ventricular arrhythmias in dogs (1988)

We delivered strong shocks via electrodes on the left ventricular apex and the right atrium in seven dogs during the T wave of atrial pacing while recordings were made from 56 epicardial electrodes. After shocks that induced arrhythmias were given, the earliest activation occurred in the middle of the ventricles for lower-energy shocks and in the base for higher-energy shocks. For shocks late in the vulnerable period, activation was recorded soon after the shock, whereas for shocks early in the vulnerable period activation was not recorded for a mean of 70 ms (+/- 17 ms SD) after the shock. We also gave 1-J shocks during right and left ventricular pacing. For shocks early in the vulnerable period, activation initiating fibrillation arose in a focal pattern from the paced region. For shocks during the midportion of the vulnerable period, fibrillation arose by two leading circle reentrant loops rotating in opposite directions, one on the left and the other on the right ventricle. For shocks at the end of the vulnerable period, the two reentrant loops fused on the side of the heart opposite the pacing site to again form a single focal activation pattern. Thus the initial activation patterns of arrhythmias initiated by shocks, the time from the shock until earliest postshock activation, and the site of earliest postshock activation are strongly influenced by the coupling interval and strength of the shock.
Getting the message: Mechanisms of protein synthesis initiation (2008)

The initiation of protein synthesis is a highly regulated process requiring recruitment and correct positioning of ribosomes on mRNA templates. We are investigating how initiation occurs on eukaryotic ribosomes, either through the actions of initiation factor proteins or via internal ribosome entry site RNAs (IRESs) that direct ribosomes to the translational start codon without requiring most initiation factors. Cellular IRESs are thought to play crucial roles in adaptation to environmental stresses that inhibit most protein synthesis. Recent results in yeast and human systems will be discussed.
Using Machine Learning and Probabilistic Frameworks to Enhance Incident and Problem Management (2015)

Problem determination and resolution (PDR) is at the core of Incident and Problem Management. PDR is the process of detecting an anomaly in a monitored system, identifying the nature of the anomaly in view of routing to the appropriate support team, determining the root cause responsible for the anomaly and fixing or eliminating the cause of the problem. The cost of PDR represents a substantial part of operational costs, and faster, more effective PDR can contribute to a substantial reduction in system administration costs. The methodologies described by the authors in this chapter relate to automation of critical aspects of PDR, such as problem classification for targeted diagnosis and structuring of solved problem tickets for offering systematized resolution to the support personnel.
Androgen receptor expression is associated with prostate cancer‐specific survival in castrate patients with metastatic disease (2009)

By univariate analysis, increased nuclear AR expression in either the diagnostic biopsy and/or radical prostatectomy specimen, from patients with advanced disease, was associated with a reduced time to prostate cancer-specific mortality.
Visual Analysis of Explicit Opinion and News Bias in German Soccer Articles (2012)

Most state-of-the-art opinion and sentiment analysis techniques were developed for customer feedback data or reviews. Applying them to another domain is often not possible because the algorithms are based on the assumption that the opinions are expressed explicitly in the text. However, news articles, for instance, convey an opinion in a more subtle manner. In this work we analyze German soccer articles with respect to the sentiment that is expressed in them. Besides adapting conventional sentiment analysis algorithms to the specific domain, we also investigate what can be measured with these techniques and what should be measured on news articles according to communication scientists. We suggest to bridge the existing gap with visual analytics methods and demonstrate the usability of the techniques on a concrete application example.