gebhart/patrepeval huggingface dataset:
Total Synthesis of the Unusual Marine Alkaloid (-)-Papuamine Utilizing a Novel Imino Ene Reaction (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal Synthesis of the Unusual Marine Alkaloid (-)-Papuamine Utilizing a Novel Imino Ene ReactionRobert M. Borzilleri, Steven M. Weinreb, and Masood ParvezCite this: J. Am. Chem. Soc. 1995, 117, 44, 10905–10913Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ja00149a013https://doi.org/10.1021/ja00149a013research-articleACS PublicationsRequest reuse permissionsArticle Views1447Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Measurement of ellipsometric data and surface orientations by modulated circular polarized light / Messung von ellipsometrischen Daten und Oberflächenorientierungen durch moduliertes zirkular polarisiertes Licht (2019)

Abstract Ellipsometry is a widely used optical method for the characterization of materials and thin films. However, only flat or nearly flat surfaces can be measured since small deviations of the angle of incidence might lead to significant experimental errors. In order to overcome the geometrical limitations of ellipsometry, the retroreflex ellipsometry developed at Fraunhofer IOSB is used. Based on this configuration, a new illumination method is proposed. When the sample is illuminated by modulated circular polarized light (LCP and RCP), the ellipsometric parameters (Ψ, Δ) and the tilted angle (Φ) can be determined directly. Combined with reflectance measurement or prior knowledge of optical properties of samples, the surface orientation can be obtained.
Virtual Fakes: DeepFakes for Virtual Reality (2019)

The proliferation of data and computational resources has led into many advancements in computer vision for facial data including easily replacing a face in one video with another one, the so called DeepFake. In this paper, we apply techniques to generate DeepFakes for virtual reality applications. We empirically validate our method by generating, for the first time, Deep Fake videos in virtual reality.
Transient response enhancement of RF MEMS tuners using digital signal processing (2017)

The transient response time and overshoot of an RF MEMS filter tuning membrane are enhanced in this work. For the first time, a dead-beat control is applied to the bias voltage of an underdamped RF MEMS membrane to achieve faster and smoother tuning. The presented method runs in real-time using a Digital Signal Processor (DSP). The parameters used by the DSP are extracted from the step response of the membrane during post-fabrication calibration. As a result, the presented methodology is systematic and immune to fabrication process variations. The presented methodology is applied on an MEMS membrane, used in tunable silicon RF filters, fabricated on an SOI wafer. Measured results show that the shaped bias voltage shortens the settling time (by 1.2–2.6x), and a significantly lowers the overshoot (by 8–60x) when compared to the voltage step response. The presented work does not require a feedback system, making it a feasible solution to embed in communication devices.
Abstract 3768: Thyroid Function and Mortality in the Sudden Cardiac Death in Heart Failure Trial (2006)

Thyroid hormone homeostasis is vital to the optimal functioning of the cardiovascular system. However, conflicting data exist regarding the degree of increased risk associated with thyroid abnormal...
Catalytic Enantioselective Addition of Sodium Bisulfite to Chalcones (2011)

At last! The addition of bisulfite to olefins, discovered over a century ago, remains the most straightforward approach to aliphatic sulfonic acids. A catalytic enantioselective procedure has now been realized that employs a bifunctional aminothiourea catalyst (see picture). Sulfonic acids were obtained from chalcones in high yields and high enantioselectivity and in both configurations. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
3D Nanoscopy with Sub-60 nm Resolution Deep Inside Tissue Using Adaptive Optics (2018)

We have developed a novel adaptive optics strategy to expand the application of isoSTED nanoscopy to thick specimens. Our strategy recovers the aberration-free point-spread function and efficiently suppresses side-lobe contributions.
NY-ESO-1 Expression in Meningioma Suggests a Rationale for New Immunotherapeutic Approaches (2013)

Meningiomas are the most common primary intracranial tumors. Surgical resection remains the treatment of choice for these tumors. However, a significant number of tumors are not surgically accessible, recur, or become malignant, necessitating the repetition of surgery and sometimes radiation. Chemotherapy is rarely used and is generally not recognized as an effective treatment. Cancer/testis (CT) genes represent a unique class of genes, which are expressed by germ cells, normally silenced in somatic cells, but activated in various cancers. CT proteins can elicit spontaneous immune responses in patients with cancer and this feature makes them attractive targets for immunotherapy-based approaches. We analyzed mRNA expression of 37 testis-restricted CT genes in a discovery set of 18 meningiomas by reverse transcription PCR. The overall frequency of expression of CT genes ranged from 5.6% to 27.8%. The most frequently expressed was NY-ESO-1, in 5 patients (27.8%). We subsequently analyzed NY-ESO-1 protein expression in a larger set of meningiomas by immunohistochemistry and found expression in 108 of 110 cases. In some cases, NY-ESO-1 expression was diffused and homogenous, but in most instances it was heterogeneous. Importantly, NY-ESO-1 expression was positively correlated with higher grade and patients presenting with higher levels of NY-ESO-1 staining had significantly worse disease-free and overall survival. We have also shown that NY-ESO-1 expression may lead to humoral immune response in patients with meningioma. Considering the limited treatment options for patients with meningioma, the potential of NY-ESO-1-based immunotherapy should be explored.
Optimization of NMR Permeability Transform and Application to a Source Rock Reservoir (2022)

Abstract Permeability is a fundamentally important property of reservoir rocks that governs the flow of the reservoir fluids and production rates. Many methods have been developed to estimate permeability, including well established and documented laboratory measurements on whole core and plugs, analysis of formation test data, and analysis of production. Obtaining permeability from nuclear magnetic resonance (NMR) T1 or T2 has proven to be a cost effective method that can provide continuous permeability along a wellbore. This method uses a transform function on NMR well log data to calculate permeability. An accurate NMR permeability transform requires calibration to fit local data of a specific field based on measured data from representative cores from the field. The general form of the permeability transform developed for conventional sandstone and carbonate reservoirs does not work well for extremely tight reservoirs such as source rocks. Here we show a generic optimization method to find the optimal permeability transform for any tight reservoirs using NMR log data and laboratory measured permeability data from samples at selected depth of the logged well. This optimization method is applied to a source rock well and a permeability transform was obtained. The transform is a function of the movable fluid in the rock and logarithm mean of the NMR relaxation time. The permeability calculated from the transform is comparable to measured permeability from core samples.
Receiver-coordinated distributed transmit nullforming with channel state uncertainty (2012)

A distributed coherent transmission scheme in which two or more transmit nodes form a beam toward an intended receiver while directing nulls at a number of other “protected” receivers is considered. Unlike pure distributed beamforming, where the ith transmit coefficient depends only on the ith transmit node's channel to the intended receiver, the transmit coefficients of a distributed nullformer each depend on the channel responses from all of the transmit nodes to all of the protected nodes. The requirement for each transmit node to know all of the channels in the system makes distributed transmit nullforming challenging to implement in the presence of channel time variations. This paper describes a receiver-coordinated distributed transmission protocol, in the context of a state-space dynamic channel model, in which the receive nodes feed back periodic channel measurements to the transmit cluster. The transmit nodes use this feedback to generate optimal channel predictions and then calculate a time-varying transmit vector that minimizes the average total power at the protected receivers while satisfying an average power constraint at the intended receiver during distributed transmission. We demonstrate via analysis and numerical simulation the efficacy of the technique even with low channel measurement overhead, infrequent update intervals, and significant feedback latency.
Design methodology with body bias: From circuit to engineering (2017)

In this paper, a built-in Body Bias design methodology is proposed and implemented in two different contexts: the automotive industry and the IoT paradigm. As opposed to the traditional design strategy, the proposed methodology incorporates Body Bias in all design stages, from synthesis to engineering. Measurements performed in a leakage-driven ADAS product and a dual core application processor in 28nm UTBB-FDSOI technology confirm the effectiveness of the proposed methodology, achieving a 30% reduction in static power, 25% in dynamic power, 15% yield recovery, and a 4X frequency and 2X leakage spread reduction.
Active‐matrix organic light‐emitting diode using inverse‐staggered poly‐Si TFTs with a center‐offset gated structure (2010)

Abstract— A low‐cost active‐matrix backplane using non‐laser polycrystalline silicon (poly‐Si) having inverse‐staggered TFTs with amorphous‐silicon (a‐Si) n + contacts has been developed. The thin‐film transistors (TFTs) have a center‐offset gated structure to reduce the leakage current without scarifying the ON‐currents. The leakage current of the center‐offset TFTs at Vg = −10 V is two orders of magnitude lower than those of the non‐offset TFTs. The center‐offset length of the TFTs was 3 μm for both the switching and driving TFTs. A 2.2‐in. QQVGA (1 60 × 1 20) active‐matrix organic light‐emitting‐diode (AMOLED) display was demonstrated using conventional 2T + 1C pixel circuits.
Quercetin induces an immunoregulatory phenotype in maturing human dendritic cells (2020)

The aryl hydrocarbon receptor (AhR) is an environmental sensor and ligand-activated transcription factor that is critically involved in the regulation of inflammatory responses and the induction of tolerance by modulating immune cells. As dendritic cells (DCs) express high AhR levels, they are efficient to induce immunomodulatory effects after being exposed to AhR-activating compounds derived from the environment or diet. To gain new insights into the molecular targets following AhR-activation in human monocyte-derived (mo)DCs, we investigated whether the natural AhR ligand quercetin or the synthetic ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) modulates the function of human moDCs regarding their capability to prime naïve T cells or to migrate. As only quercetin, but not TCDD, impaired T cell activation and migration of LPS-matured DCs (LPS-DCs), we analyzed the mode of action of quercetin on moDCs in more detail. Here, we found a specific down-regulation of the immunomodulatory molecule CD83 through the direct binding of the activated AhR to the CD83 promoter. Furthermore, treatment of LPS-DCs with quercetin resulted in a reduced production of the pro-inflammatory cytokine IL-12p70 and in an increased expression of the immunoregulatory molecules disabled adaptor protein (Dab) 2, immunoglobulin-like transcript (ILT)-3, ILT4, ILT5 as well as ectonucleotidases CD39 and CD73, thereby inducing a tolerogenic phenotype in quercetin-treated maturing DCs. Overall, these data demonstrate that quercetin represents a potent immunomodulatory agent to alter human DC phenotype and function, shifting the immune balance from inflammation to resolution.
ChemInform Abstract: Macrocyclic Coordination Chemistry (2012)

Abstract Review: 114 refs.
Screening Peanut Germplasm for Resistance to Corn Earworm1 (1984)

Abstract The corn earworm (Heliothis zea Boddie) commonly causes damage to peanut (Arachis hypogaea L.) in North Carolina. Resistance to the corn earworm has been identified in peanut and correlated with resistances to tobacco thrips (Frankliniella fusca Hinds), potato leafhopper (Empoasca fabae Harris), and the southern corn rootworm (Diabrotica undecimpunctata howardi Barber). Development of corn earworm-resistant cultivars which might also assist in managing several insect pests could be aided by an understanding of the nature and inheritance of corn earworm resistance. This study was conducted to develop a laboratory procedure to screen for corn earworm resistance, to determine the relationship between laboratory and field measurements of resistance, to determine the chemical basis of resistance, and to determine the inheritance of resistance. Neither the laboratory measurement of larval growth after feeding of fresh leaf tissue nor after feeding on a synthetic diet containing ground freeze-dried leaf tissue consistently separated resistant and susceptible germplasms. Because of the inconsistency in laboratory tests, the relationship between lab and field results was inconsistent. Since these procedures did not always distinguish resistant and susceptible genotypes, these techniques cannot be used in lieu of field screening. However, these studies do suggest that antibiosis is a major component of corn earworm resistance. Chemical analyses indicate that a flavone glycoside is probably responsible for the antibiotic response. Neither field nor laboratory evaluations of progencies from the cross of NC 6 (resistant) and Florigiant line C (susceptible) could be used to separate plants into resistant and susceptible classes. Antibiosis did appear to be a dominant trait for this cross.
Live Bird Markets of Bangladesh: H9N2 Viruses and the Near Absence of Highly Pathogenic H5N1 Influenza (2011)

Avian influenza surveillance in Bangladesh has been passive, relying on poultry farmers to report suspected outbreaks of highly pathogenic H5N1 influenza. Here, the results of an active surveillance effort focusing on the live-bird markets are presented. Prevalence of influenza infection in the birds of the live bird markets is 23.0%, which is similar to that in poultry markets in other countries. Nearly all of the isolates (94%) were of the non-pathogenic H9N2 subtype, but viruses of the H1N2, H1N3, H3N6, H4N2, H5N1, and H10N7 subtypes were also observed. The highly pathogenic H5N1-subtype virus was observed at extremely low prevalence in the surveillance samples (0.08%), and we suggest that the current risk of infection for humans in the retail poultry markets in Bangladesh is negligible. However, the high prevalence of the H9 subtype and its potential for interaction with the highly pathogenic H5N1-subtype, i.e., reassortment and attenuation of host morbidity, highlight the importance of active surveillance of the poultry markets.
Design, analysis and fabrication of a high-performance fractional-slot concentrated winding surface PM machine (2010)

A high-performance 55 kW (peak) fractional-slot concentrated winding (FSCW) surface permanent magnet (SPM) machine has been designed to meet demanding performance requirements based on the FreedomCar advanced traction motor requirements prepared by the US Department of Energy. This paper describes key steps in the design, analysis, fabrication, and testing of this machine. Design challenges arising from the high-speed, high-efficiency requirements are presented followed by a discussion of design features that have been introduced to address them. A prototype version of the machine has been fabricated using a segmented stator configuration and segmented neodymium-iron rotor magnets. Test results gathered to date demonstrate promising torque production and efficiency characteristics that are consistent with the machine performance predictions.
Performance of Soft-Decision FEC in Systems with Bivariate Gaussian Noise Distributions (2011)

We demonstrate through analysis and Monte Carlo simulations how general bivariate Gaussian noise impacts the performance of soft-decision low-density parity-check (LDPC) codes designed for additive, circularly symmetric Gaussian noise.
Site-specific phosphorylation of PSD-95 dynamically regulates the post-synaptic density as observed by phase separation (2021)

SUMMARY Postsynaptic density protein 95 is a key scaffolding protein in the postsynaptic density of excitatory glutamatergic neurons, organizing signaling complexes primarily via its three PSD-95/Discs-large/Zona occludens domains. PSD-95 is regulated by phosphorylation, but technical challenges have limited studies of the molecular details. Here, we genetically introduced site-specific phosphorylations in single, tandem and full-length PSD-95 and generated a total of 11 phosphorylated protein variants. We examined how these phosphorylations affected binding to known interaction partners and the impact on phase separation of PSD-95 complexes, and identified two new phosphorylation sites with opposing effects. Phosphorylation of Ser78 inhibited phase separation with the glutamate receptor subunit GluN2B and the auxiliary protein stargazin, whereas phosphorylation of Ser116 induced phase separation with stargazin only. Thus, by genetically introducing phosphoserine site-specifically and exploring the impact on phase separation, we have provided new insights into the regulation of PSD-95 by phosphorylation and the dynamics of the PSD. Graphical Abstract: Phosphorylation of PSD-95. Illustration of the interaction between the PDZ domains of PSD-95 and the NMDA receptor (NMDAR) (PDB: 4PE5) at the plasma membrane. PSD-95 interacts with the AMPA receptor (AMPAR) (PDB: 3KG2) through Stargazin (PDB: 5KBU). Using the software Ranch, a model of FL PSD-95 was generated using known structural domains of PSD-95 connected via a fully-flexible linker (PDZ1-2, PDB: 3GSL; PDZ3, PDB: 5JXB; SH3-GK, PDB: 1KJW). Illustration of the effect of phosphorylation of PSD-95 on the formation of condensates at the PSD. PSD-95 can phase separate with receptors and intracellular proteins, and phosphorylation is can affect this interaction and lead to alterations, both negative and positive, in the formation of condensates.
Transformer synthesis for VHF converters (2010)

This document presents a method to synthesize an air-core transformer with a given inductance matrix. The proposed algorithm is used to design a two-winding transformer for a Φ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> resonant dc-dc converter operating in the VHF (30-300 MHz) regime. The method realizes the required inductance matrix to achieve proper tuning while trading volume and efficiency. Two sets of transformers were fabricated and the measured results compared against predictions. Using one of the transformers, a 75 MHz isolated Φ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> converter is constructed and tested. The efficiency of the transformer was verified through thermal measurements to be approximately 94%.
High brightness laser diode array at 940 nm for Yb:YAG pumping (2007)

The PFS project (Petawatt Field Synthesizer) of the Max-Planck-Institute for Quantum Optics aims at chirped pulse optical parametric amplification (OPCPA) to the 5 joule level with a pulse duration of 5 fs after re-compression at a repetition rate of 10 Hz. Within the HYDRA system (High energy Ytterbium based Diode-pumped Rep-rated Amplifier) which is a 50 TW CPA laser system synchronous pump pulses for the OPA chain based on KDP will be generated. Applying SHG process followed by re-compression the pump laser system is designed for delivery of pulses with 20 joules pulse energy at 515 nm. Starting from a Ti:Sa oscillator for the OPA chain the HYDRA amplifiers are seeded with pico-second pulses stretched into the nanosecond time scale after beam splitting band filtering. The pulse energy of regeneratively amplified ns-pulses will be boosted from 100 mJ to the 50 J level by two multi-pass Yb:YAG amplifier stages.
“Commemorating the 20th Anniversary of the Kyoto Cornea Club,” 20th Annual Meeting of the Kyoto Cornea Club, December 5 and 6, 2014 (2015)

Oshika, Tetsuro MD, PhD; Nishida, Kohji MD, PhD; Saika, Shizuya MD, PhD; Fukushima, Atsuki MD, PhD Author Information
MAPK6-AKT signaling promotes tumor growth and resistance to mTOR kinase blockade (2021)

Mitogen-activated protein kinase 6 (MAPK6) is an atypical MAPK. Its function in regulating cancer growth remains elusive. Here, we reported that MAPK6 directly activated AKT and induced oncogenic outcomes. MAPK6 interacted with AKT through its C34 region and the C-terminal tail and phosphorylated AKT at S473 independent of mTORC2, the major S473 kinase. mTOR kinase inhibitors have not made notable progress in the clinic. Our identified MAPK6-AKT axis may provide a major resistance pathway. Besides repressing growth, inhibiting MAPK6 sensitized cancer cells to mTOR kinase inhibitors. MAPK6 overexpression is associated with decreased overall survival and the survival of patients with lung adenocarcinoma, mesothelioma, uveal melanoma, and breast cancer. MAPK6 expression also correlated with AKT phosphorylation at S473 in human cancer tissues. We conclude that MAPK6 can promote cancer by activating AKT independent of mTORC2 and targeting MAPK6, either alone or in combination with mTOR blockade, may be effective in cancers.
Physical gelation of AB-alternating copolymers made of vinyl phenol and maleimide units: cooperation between precisely incorporated phenol and long alkyl pendant groups (2019)

Alternating copolymers of vinyl phenol and alkyl maleimide gave organogel in aromatic solvents. The gelation was induced by segregation.