gebhart/patrepeval huggingface dataset:
Supplemental Figure 3 from Generation 2.5 Antisense Oligonucleotides Targeting the Androgen Receptor and Its Splice Variants Suppress Enzalutamide-Resistant Prostate Cancer Cell Growth (2023)

&lt;p&gt;Supplemental Figure 3. AR full length was highly expressed in nucleus of ENZ-R compared to CR LNCaP xenograft tumors.&lt;/p&gt;
Neointima Formed by Arterial Smooth Muscle Cells Expressing Versican Variant V3 Is Resistant to Lipid and Macrophage Accumulation (2011)

These results demonstrate that expression of V3 in vessel wall creates an elastin-rich neointimal matrix that in the presence of hyperlipidemia is resistant to lipid deposition and macrophage accumulation.
Experimental Evaluation of Backpropagation-Based Background Compensation of TI-ADC with Application to Digital Communication Receivers (2021)

This paper presents an experimental evaluation of the backpropagation-based technique for the background compensation of time-interleaved analog to digital converters (TI-ADC). Measurements obtained on an 8 bit, 4 GS/s TI-ADC test chip fabricated in 130 nm CMOS technology demonstrate the effectiveness of this technique. Backpropagation-based background compensation of TI-ADC is typically used in high-speed digital communication receivers. Historically, the error backpropagation algorithm has been used to train neural networks in machine learning applications. In a TI-ADC compensation application, the error at the symbol detection stage of a digital receiver is processed by the backpropagation algorithm to compute an equivalent error at the TI-ADC output, which otherwise would not be directly observable. Then, the backpropagated error can be applied to train a low-complexity adaptive equalizer which compensates the TI-ADC mismatches. In comparison with prior art, the main advantages of this technique are its robustness, its high convergence speed, and its intrinsic background operation. Measurements with the aforementioned test chip show that the impact of the TI-ADC mismatch on the receiver performance is eliminated. In addition, an improvement in both the SNDR and SFDR of almost 24 dB and 25.6 dB, respectively, is observed at the Nyquist frequency when the compensation is applied.
Ischiofemoral impingement and hamstring dysfunction as a potential pain generator after ischial tuberosity apophyseal fracture non-union/malunion (2015)

IV.
Heterogeneous Architecture Support for Wireless Network Dynamics and Mobility (2000)

Abstract : In this paper, we examine network architecture issues and protocols for applicability to mobile and dynamic wireless communication networks. Our focus is on networking technology to provide heterogeneous support and interoperability with existing and planned internetworking infrastructures and applications. First, we discuss engineering issues and technology components across a broad range of mobile networking system elements. Second, we focus in detail on a number of critical technology areas relating to mobility support and interoperability with the Internet Protocol (IP) suite. Our goal is to highlight important issues, provide guidance in examining architectural and protocol tradeoffs and help assess the maturity of technology components for near term deployment of network systems and further experimentation in ongoing mobile network projects. Since there is not a definitive one size fits all solution space to the design components involved in mobile networking, a future follow-on study is planned to provide more project-specific recommendations for specific wireless networking technology architectures and requirements-e.g. Interoperable Networks for Secure Communications (lNSC).
Low-cost time-gated imager for intraoperative nerve identification (2021)

Intraoperative nerve recognition is critical to avoid accidental transection. Fluorescence-guided surgery can aid in nerve identification. However, detection of weak nerve-specific fluorescence signal is susceptible to the interference from high-background bright lights. We present a time-gated imager designed with ease-of-use and cost effectiveness in mind. Using this technology, we demonstrate successful rejection of room-light background signal to visualize the murine sciatic nerve.
High-speed I/O (2003)

The design of modern operating systems is based around the concept of memory as a cache for data that flows between applications, storage, and I/O devices. With the increasing disparity between I/O bandwidth and CPU performance, this architecture exposes the processor and memory subsystems as the bottlenecks to system performance. Furthermore, this design does not easily lend itself to exploitation of new capabilities in peripheral devices, such as programmable network cards or special-purpose hardware accelerators, capable of card-to-card data transfers.We propose a new operating system architecture that removes the memory and CPU from the data path. The role of the operating system becomes that of data-flow management, while applications operate purely at the signaling level. This design parallels the evolution of modern network routers, and has the potential to enable high-performance I/O for end-systems, as well as fully exploit recent trends in programmability of peripheral (I/O) devices.
Understanding gastrointestinal perfusion in critical care: so near, and yet so far. (2000)

An association between abnormal gastrointestinal perfusion and critical illness has been suggested for a number of years. Much of the data to support this idea comes from studies using gastric tonometry. Although an attractive technology, the interpretation of tonometry data is complex. Furthermore, current understanding of the physiology of gastrointestinal perfusion in health and disease is incomplete. This review considers critically the striking clinical data and basic physiological investigations that support a key role for gastrointestinal hypoperfusion in initiating and/or perpetuating critical disease.
Copolymerization of propylene with styrene using the catalyst system composed of Solvay type titanium trichloride and Cp2TiMe2 (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCopolymerization of propylene with styrene using the catalyst system composed of Solvay type titanium trichloride and Cp2TiMe2Kazuo Soga and Hisayoshi YanagiharaCite this: Macromolecules 1989, 22, 7, 2875–2878Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/ma00197a001https://doi.org/10.1021/ma00197a001research-articleACS PublicationsRequest reuse permissionsArticle Views214Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
POSTERIOR HUMERAL AVULSION OF THE GLENOHUMERAL LIGAMENT AS A CAUSE OF POSTERIOR SHOULDER INSTABILITY (2004)

Safran, Ori MD; DeFranco, Michael J. MD; Hatem, Stephen MD; Iannotti, Joseph P. MD, PhD Author Information
Multiple‐Oxidation‐State Tungsten‐Oxide Clusters on a Carbon Surface as an Intersection between Molecular and Bulk Oxides (2021)

Abstract Bulk tungsten oxides exhibit a wide range of oxidation states, whereas the oxidation states available in molecular oxides such as polyoxometalates (POMs) is limited. In this paper, tungsten oxide clusters with diameters of 1.2±0.4 ( W 60 O x /C ), 1.1±0.4 ( W 28 O x /C ), and 0.9±0.3 nm ( W 12 O x /C ) were produced in a size‐selective manner on graphitic carbon by using a phenyl‐azomethine‐type dendrimer as a template and applying hydrogen reduction after fixing the dendrimers on a support. X‐ray photoelectron spectroscopy revealed that the W atoms in the clusters exhibited multiple oxidation states, i. e., W δ + , W 4+ , W 5+ , and W 6+ . Moreover, X‐ray absorption fine structure measurements indicated the W−W bond length of 2.84–2.85±0.01 Å in these clusters. Auto‐oxidation with adventitious oxygen after hydrogen reduction is proposed as a reasonable mechanism for the formation of these clusters on the carbon surface.
julia: v0.4.0 (2015)

The Julia Language: A fresh approach to technical computing.
Motor Functions of the Superior Colliculus (2011)

The mammalian superior colliculus (SC) and its nonmammalian homolog, the optic tectum, constitute a major node in processing sensory information, incorporating cognitive factors, and issuing motor commands. The resulting action-to orient toward or away from a stimulus-can be accomplished as an integrated movement across oculomotor, cephalomotor, and skeletomotor effectors. The SC also participates in preserving fixation during intersaccadic intervals. This review highlights the repertoire of movements attributed to SC function and analyzes the significance of results obtained from causality-based experiments (microstimulation and inactivation). The mechanisms potentially used to decode the population activity in the SC into an appropriate movement command are also discussed.
Photoinduced electron transfer chemistry of 2,3-dicyanonaphthalene (1999)

The electron transfer photochemistry of 2,3-dicyanonaphthalene has been studied by a combination of fluorescence and transient absorption spectroscopy. The singlet excited state has a lifetime of 26 ns in acetonitrile and reacts with aromatic and alkene donors with oxidation potentials less than ~1.8 V with rate constants that are close to the diffusion-controlled limit. Transient absorption measurements demonstrate that the fluorescence quenching leads to efficient formation of free-radical ions. The radical ion yields have been measured for several donors and are compared to those for the more commonly used sensitizer, 1.4-dicyanonaphthalene. In the absence of added donors, direct excitation of 2,3-dicyanonaphthalene provides evidence for photoionization at high laser energy, in addition to triplet formation. The results illustrate the utility of this sensitizer for photoinduced electron transfer reactions.Key words: photoinduced electron transfer, laser flash photolysis, fluorescence, photosensitizers.
Chicken Anemia Virus VP2 Is a Novel Dual Specificity Protein Phosphatase (2002)

The function of viral protein 2 (VP2) of the immunosuppressive circovirus chicken anemia virus (CAV) has not yet been established. We show that the CAV VP2 amino acid sequence has some similarity to a number of eukaryotic, receptor, protein-tyrosine phosphatase (PTPase) alpha proteins as well as to a cluster of human TT viruses within the Sanban group. To investigate if CAV VP2 functions as a PTPase, purified glutathione S-transferase (GST)-VP2 fusion protein was assayed for PTPase activity using the generalized peptide substrates ENDpYINASL and DADEpYLIPQQG (where pY represents phosphotyrosine), with free phosphate detected using the malachite green colorimetric assay. CAV GST-VP2 was shown to catalyze dephosphorylation of both substrates. CAV GST-VP2 PTPase activity for the ENDpYINASL substrate had a V(max) of 14,925 units/mg.min and a K(m) of 18.88 microm. Optimal activity was observed between pH 6 and 7, and activity was specifically inhibited by 0.01 mm orthovanadate. We also show that the ORF2 sequence of the CAV-related human virus TT-like minivirus (TLMV) possessed PTPase activity and steady state kinetics equivalent to CAV GST-VP2 when expressed as a GST fusion protein. To establish whether these viral proteins were dual specificity protein phosphatases, the CAV GST-VP2 and TLMV GST-ORF2 fusion proteins were also assayed for serine/threonine phosphatase (S/T PPase) activity using the generalized peptide substrate RRApTVA, with free phosphate detected using the malachite green colorimetric assay. Both CAV GST-VP2 and TLMV GST-ORF2 fusion proteins possessed S/T PPase activity, which was specifically inhibited by 50 mm sodium fluoride. CAV GST-VP2 exhibited S/T PPase activity with a V(max) of 28,600 units/mg.min and a K(m) of 76 microm. Mutagenesis of residue Cys(95) to serine in CAV GST-VP2 abrogated both PTPase and S/T PPase activity, identifying it as the catalytic cysteine within the proposed signature motif. These studies thus show that the circoviruses CAV and TLMV encode dual specificity protein phosphatases (DSP) with an unusual signature motif that may play a role in intracellular signaling during viral replication. This is the first DSP gene to be identified in a small viral genome.
Patterning Cells on Optically Transparent Indium Tin Oxide Electrodes (2007)

The ability to exercise precise spatial and temporal control over cell-surface interactions is an important prerequisite to the assembly of multi-cellular constructs serving as in vitro mimics of native tissues. In this study, photolithography and wet etching techniques were used to fabricate individually addressable indium tin oxide (ITO) electrodes on glass substrates. The glass substrates containing ITO microelectrodes were modified with poly(ethylene glycol) (PEG) silane to make them protein and cell resistive. Presence of insulating PEG molecules on the electrode surface was verified by cyclic voltammetry employing potassium ferricyanide as a redox reporter molecule. Importantly, the application of reductive potential caused desorption of the PEG layer, resulting in regeneration of the conductive electrode surface and appearance of typical ferricyanide redox peaks. Application of reductive potential also corresponded to switching of ITO electrode properties from cell non-adhesive to cell-adhesive. Electrochemical stripping of PEG-silane layer from ITO microelectrodes allowed for cell adhesion to take place in a spatially defined fashion, with cellular patterns corresponding closely to electrode patterns. Micropatterning of several cell types was demonstrated on these substrates. In the future, the control of the biointerfacial properties afforded by this method will allow to engineer cellular microenvironments through the assembly of three or more cell types into a precise geometric configuration on an optically transparent substrate.
CO2 Adsorption on Dahlia-Like Carbon Nanohorns: Isosteric Heat and Surface Area Measurements (2011)

We present the results of an adsorption study of carbon dioxide on closed dahlia-like single-walled carbon nanohorn aggregates. The study was conducted to explore the sorptive capacity of the nanohorns and the dependence of the CO2's isosteric heat of adsorption on sorbent loading. We found that there are no steps present in the carbon dioxide isotherms and that the isosteric heat of adsorption has an unusual nonmonotonic dependence on loading. Both of these behaviors are opposite to what is observed for other simple gases (argon, methane, neon, etc.) adsorbed on the same sorbent. The effective specific surface area of the nanohorn aggregates was determined using the BET and point-B methods.
Iridium(III) Complexes Bearing Tridentate Chromophoric Chelate: Phosphorescence Fine-Tuned by Phosphine and Hydride Ancillary (2018)

Functional 2-pyrazolyl-6-phenylpyridine chelates-namely, (pzpyph<sup>Bu</sup>)H<sub>2</sub> and (pzpyph<sup>CF<sub>3</sub></sup>)H<sub>2</sub> and phosphines-are successfully employed in the preparation of emissive Ir(III) metal complexes, for which the reaction with phosphine such as PPh<sub>3</sub>, PPh<sub>2</sub>Me, and PPh<sub>2</sub>(CH<sub>2</sub>Ph) afford corresponding Ir(III) complexes [Ir(pzpyph<sup>Bu</sup>)(PPh<sub>3</sub>)<sub>2</sub>H] (1a), [Ir(pzpyph<sup>CF<sub>3</sub></sup>)(PPh<sub>2</sub>R)<sub>2</sub>H] (2a-2c), R = Ph, Me, CH<sub>2</sub>Ph, which also show an equatorial coordinated hydride. In contrast, treatment with 1,2-bis(diphenylphosphino)benzene (dppb) and 1,2-bis(diphenylphosphino)ethane (dppe) yields the isomeric products [Ir(pzpyph<sup>Bu</sup>)(dppb)H] (3a) and [Ir(pzpyph<sup>Bu</sup>)(dppe)H] (3b), for which the distinctive, axial hydride undergoes rapid chlorination, forming chlorinated complexes [Ir(pzpyph<sup>Bu</sup>)(dppb)Cl] (4a) and [Ir(pzpyph<sup>Bu</sup>)(dppe)Cl] (4b), respectively. On the other hand, upon extensive heating of 2c, one of its coordinated PPh<sub>2</sub>(CH<sub>2</sub>Ph) exhibits benzyl cyclometalation and hydride elimination to afford [Ir(pzpyph<sup>CF<sub>3</sub></sup>)(PPh<sub>2</sub>R)(PPh<sub>2</sub>R')] (5c and 6c) R = CH<sub>2</sub>Ph and R' = CH<sub>2</sub>( o-C<sub>6</sub>H<sub>4</sub>) as the kinetic and thermodynamic products, respectively. Their structural, photophysical, and electrochemical properties are examined and further affirmed by the computational approaches.
Innovation in Hydrotesting Above Ground Pipes: Analytical Solution via Integral Transforms for Discerning Test Fluid Temperatures Subject to Ambient Temperature Variations (2021)

Abstract Hydrostatic testing for strength and leaks of newly constructed pipelines are required by code. However, for exposed pipes challenges are encountered since ambient conditions can influence pressure responses. Additionally, there is uncertainty as to whether the temperatures measured at a pipe’s outer wall, which are used to compute the expected pressure profiles, are representative of the testing fluid. To help bridge the gap, this work demonstrates the use of integral transforms for analytically solving the non-homogeneous 1D transient equations prescribed for the fluid temperature inside a cylindrical pipe. The solution identified provides sufficient generality to accommodate arbitrary initial conditions and ambient temperature variations. Furthermore, a rate of change function is formulated which enables a direct assessment of the temperature equality assumption between the fluid and the pipe wall. The validity of the solution is then substantiated by demonstrating excellent agreement with results reported in the literature (for a scenario describing typical hydrotest conditions). From the results obtained it can be observed that as the Biot number increases the temperature equality assumption begins to break down. Finally, a simplified expression for the relationship between the rate of change of the ambient air and the average fluid temperatures was formulated for this special scenario, which again showed agreement with the results in the literature.
Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1 (2015)

Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads todeleterious effects on the kidney, blood vessels, and heart. Although steroidal antagonists such as spironolactone and eplerenone are clinically useful for the treatment of cardiovascular diseases, they are associated with several side effects. Finerenone, a novel nonsteroidal MR antagonist, is presently being evaluated in two clinical phase IIb trials. Here, we characterized the molecular mechanisms of action of finerenone and spironolactone at several key steps of the MR signaling pathway. Molecular modeling and mutagenesis approaches allowed identification of Ser-810 and Ala-773 as key residues for the high MR selectivity of finerenone. Moreover, we showed that, in contrast to spironolactone, which activates the S810L mutant MR responsible for a severe form of early onset hypertension, finerenone displays strict antagonistic properties. Aldosterone-dependent phosphorylation and degradation of MR are inhibited by both finerenone and spironolactone. However, automated quantification of MR subcellular distribution demonstrated that finerenone delays aldosterone-induced nuclear accumulation of MR more efficiently than spironolactone. Finally, chromatin immunoprecipitation assays revealed that, as opposed to spironolactone, finerenone inhibits MR, steroid receptor coactivator-1, and RNA polymerase II binding at the regulatory sequence of the SCNN1A gene and also remarkably reduces basal MR and steroid receptor coactivator-1 recruitment, unraveling a specific and unrecognized inactivating mechanism on MR signaling. Overall, our data demonstrate that the highly potent and selective MR antagonist finerenone specifically impairs several critical steps of the MR signaling pathway and therefore represents a promising new generation MR antagonist.
Performance study of a high performance information/control frame multiplexer (2002)

The performance of a control (CNTR) and information (INF) frame multiplexer which intermixes control and information traffic by accommodating the relatively short CNTR frames between two consecutive INF frames is investigated. It is shown that the delay performance of one class can be improved at the price of degrading the performance of the other. The delay performance of a transaction between two nodes of the communication subsystem can be improved by selecting the parameters of this multiplexer appropriately. The relative importance of CNTR and INF frame delays for a transaction is determined. The results of a simulation study give insight into the behavior of this multiplexer. Based on these results, it is concluded that if the control traffic intensity is high, or the relative importance of control delay is high, then larger values of gap length improve the performance.
Kinetic Viability Assays Using DRAQ7 Probe (2013)

Cell death within cell populations is a stochastic process where cell-to-cell variation in temporal progression through the various stages of cell death arises from asynchrony of subtle fluctuations in the signaling pathways. Most cell death assays rely on detection of the specific marker of cell demise at the end-point of cell culturing. Such an approach cannot account for the asynchrony and the stochastic nature of cell response to the death-inducing signal. There is a need therefore for rapid and high-throughput bioassays capable of continuously tracking viability of individual cells from the time of encountering a stress signal up to final stages of their demise. In this context, a new anthracycline derivative, DRAQ7, is gaining increasing interest as an easy-to-use marker capable of long-term monitoring of cell death in real-time. This novel probe neither penetrates the plasma membrane of living cells nor does it affect the cells' susceptibility to the death-inducing agents. However, when the membrane integrity is compromised, DRAQ7 enters cells undergoing demise and binds readily to nuclear DNA to report cell death. Here, we provide three sets of protocols for viability assays using DRAQ7 probe. The first protocol describes the innovative use of single-color DRAQ7 real-time assay to dynamically track cell viability. The second protocol outlines a simplified end-point DRAQ7 staining approach. The final protocol highlights the real-time and multiparametric apoptosis assay utilizing DRAQ7 dye concurrently with tetramethylrhodamine methyl ester (TMRM), the mitochondrial trans-membrane electrochemical potential (ΔΨm) sensing probe.