gebhart/patrepeval huggingface dataset:
Conolysin-Mt:  A Conus Peptide That Disrupts Cellular Membranes (2007)

Conus venoms are estimated to comprise over 100,000 distinct pharmacologically active peptides, the majority probably targeting ion channels. Through the characterization of a cytolytic peptide from the venom of Conus mustelinus, conolysin-Mt, we expand the known conopeptide mechanisms to include association with and destruction of cellular membranes. A new 23AA conopeptide, conolysin-Mt has potent hemolytic activity when tested on human erythrocytes. At a concentration of 0.25 microM, the peptide permeabilized both negatively charged prokaryotic (PE:PG) and zwitterionic eukaryotic (PC:cholesterol) model membranes. The affinity constants (KA) of conolysin-Mt for PE:PG and PC:cholesterol model membranes were 0.9 +/- 0.3 x 10(7) and 3 +/- 1 x 10(7) M-1, respectively. In contrast, conolysin-Mt exhibited low antimicrobial activity (MIC > 50 microM) against two Escherichia coli strains, with an MIC for the Gram-positive S. aureus of 25-50 microM. The specificity of conolysin-Mt for native eukaryotic membranes is a novel feature of the peptide compared to other well-characterized cytolytic peptides such as melittin.
Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats (2013)

Diabetes causes cardiomyopathy through a copper-mediated mechanism that incorporates myocardial copper deficiency, whereas TETA treatment prevents this response and maintains the integrity of cardiac structure and myofibrillar calcium sensitivity. Altered calcium homeostasis may not be the primary defect in diabetic cardiomyopathy. Rather, a newly-described copper-mediated mechanism may cause this disease.
The role of inorganic electrolyte (salt) in cellulosic fibre dyeing: Part 2 theories of how inorganic electrolyte promotes dye uptake (2021)

Abstract This review concerns the application of vat dyes, sulphur dyes, azoic colorants, direct dyes and reactive dyes to both natural and man‐made cellulosic fibres from aqueous dyebaths using exhaust dyeing processes and the role of added inorganic electrolyte in such dyeing processes. In this part of the paper, the various theories/hypotheses/concepts which have been proposed to account for the promotional effect exerted by added inorganic electrolyte on dye uptake are reviewed and scrutinised, from the viewpoints of the essential physico‐chemical properties of the five classes of dye used and the fundamental aspects of their application.
Severe prolonged posture-evoked tachycardia after massive overdose of paliperidone (2016)

"Severe prolonged posture-evoked tachycardia after massive overdose of paliperidone." Clinical Toxicology, 54(6), p. 535
Moment estimation of customer loss rates from transactional data (1998)

Moment estimators are proposed for the arrival and customer loss rates of a many‐server queueing system with a Poisson arrival process with customer loss via balking or reneging. These estimators are based on the lengths { S j 1 } of the initial inter‐departure intervals of the busy periods j = 1, …, M observed in a dataset consisting of service starting and finishing times and encompassing both busy and idle periods of the process, and whether those busy periods are of length 1 or &gt;1. The estimators are compared with maximum likelihood and parametric model‐based estimators found previously.
Click chemistry based biomolecular conjugation monitoring using surface-enhanced Raman spectroscopy mapping (2016)

We describe here a novel surface-enhanced Raman spectroscopy (SERS) based technique for monitoring the conjugation of small molecules by the well-known click reaction between an alkyne and azido moiety on the partner molecules. The monitoring principle is based on the loss of the characteristic alkyne/azide Raman signal with triazole formation in the reaction as a function of time. Since these universal Raman reporter groups are specific for click reactions, this method may facilitate a broad range of applications for monitoring the conjugation efficiency of molecules in diverse areas such as bioconjugation, material science or drug discovery. Additionally, as an attractive advantage of this technique, no significant background signal is expected during the measurements, since these signals reside in a Raman silent region of 2000-2300 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> , where virtually all biological molecules are transparent.
Schmorl Nodes Can Cause Increased 68Ga DOTATATE Activity on PET/CT, Mimicking Metastasis in Patients With Neuroendocrine Malignancy (2015)

Schmorl node (SN) is the herniation of the nucleus pulposus through the cartilaginous and bony endplate into the adjacent vertebral body. It is documented that SNs produce areas of moderately increased F-FDG uptake. We present a case of a patient with history of neuroendocrine tumor, who underwent Ga DOTATATE PET/CT for follow-up, showing increased focal vertebral uptake suggestive of bone metastasis. CT revealed typical findings of an SN. The presented case indicates that SNs should be considered when encountering focally increased skeletal uptake in Ga DOTATATE PET/CT studies, which can mimic metastasis in patients with history of neuroendocrine tumors.
Laminar fluid flow in microchannels with complex shape (2014)

This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.
New Extraction Method of the Bipolar Transistor Model Parameters Used in Bandgap Type Voltage References (2019)

A new extraction method of the critical model parameters affecting temperature variation of the bandgap type voltage reference is presented. According to the new method, the two model parameters describing the linear and non-linear temperature dependence of the bandgap type voltage references are extracted from the raw data of the reference voltage vs. temperature and not from direct measurements of the bipolar transistor.
Movie S3 AT48 1microM from Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis (2023)

&lt;p&gt;Movie S3 AT48 1microM. 690 melanoma cells seeded on thick Col-I gel and treated with 1micM AT48 for 24h.&lt;/p&gt;
Chapter 10: Evaluation of longitudinal dynamic regimes with and without marginal structural working models (2015)

10.1 ▪ Introduction Adapting prevention and treatment interventions delivered to a patient based on that patient's characteristics is central to the practice of medicine. Common examples include use of risk scores to triage patients to more and less intensive screening and other prevention interventions, initiation of treatment only when patient characteristics suggest that long term benefits are thought to outweigh long term risks, selection among possible treatment regimens based on predictors of response and adverse effects, and modification/discontinuation of current regimens in response to adverse effects or early response. Methods for estimating the effects of such dynamic regimes, as well as for estimating the optimal regime, are particularly interesting for cases in which tradeoffs exist between treatment alternatives. For example, if treatment carries a risk of substantial toxicity, learning how best to decide when and for whom expected benefits outweigh risks can substantially improve outcomes. In some cases, a single composite outcome (such as mortality) may suffice; Chapter 15 provides a discussion of alternative approaches for problems with distinct competing outcomes. Dynamic regimes also have particular relevance for comparative effectiveness research in which multiple interventions with previously demonstrated efficacy are compared head-to-head. When, as is often the case, the most effective intervention both varies between individuals and may change for a given individual over time, both effectiveness and cost-effectiveness can be improved by learning how best to target the right intervention to the right patient at the right time.
Host-Enhanced Phenyl-Perfluorophenyl Polar−π Interactions (2020)

Phenyl-perfluorophenyl polar-π interactions have been revisited for the design and fabrication of functional supramolecular systems. The relatively weak associative interactions (Δ<i>G</i> ≈ -1.0 kcal/mol) have limited their use in aqueous self-assembly to date. Herein, we propose a strategy to strengthen phenyl-perfluorophenyl polar-π interactions by encapsulation within a synthetic host, thus increasing the binding affinity to Δ<i>G</i>= -15.5 kcal/mol upon formation of heteroternary complexes through social self-sorting. These heteroternary complexes were used as dynamic, yet strong, cross-linkers in the fabrication of supramolecular gels, which exhibited excellent viscoelasticity, stretchability, self-recovery, self-healing, and energy dissipation. This work unveils a general approach to exploit host-enhanced polar-π interactions in the design of robust aqueous supramolecular systems.
ACS Chemical Neuroscience: Most Cited Papers from 2016 (2017)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTACS Chemical Neuroscience: Most Cited Papers from 2016Craig W. LindsleyCite this: ACS Chem. Neurosci. 2017, 8, 10, 2097–2098Publication Date (Web):October 18, 2017Publication History Published online18 October 2017Published inissue 18 October 2017https://pubs.acs.org/doi/10.1021/acschemneuro.7b00354https://doi.org/10.1021/acschemneuro.7b00354editorialACS PublicationsCopyright © 2017 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views831Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (1 MB) Get e-AlertscloseSUBJECTS:Chemical neuroscience,Dietary supplements,Drug discovery,Nervous system diseases,Toxicity Get e-Alerts
Two-dimensional finite-element method analysis of various antennas for ICRF plasma heating (1989)

Two-dimensional finite-element analysis is performed for ion-cyclotron range of frequency (ICRF) antennas with various cross-sectional configurations. Interest is mainly focused on the quantitative difference in the input impedance among various antennas such as the normal loop antenna, the antenna with surrounding limiter walls, and the antenna buried into the cutoff cavity. For analytical simplicity, the cold plasma approximation is used. The numerical results show how the input impedance is affected by the presence of the limiter walls or the cutoff cavity. The code described can be applied to the designs of ICRF antennas with a wide range of plasma parameters and antenna geometries.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Content and context-based multi-label image annotation (2009)

In this paper, we propose a multi-label image annotation framework by incorporating the content and context information of images. Specifically, images are annotated on regional scale. This annotation is independent of the sizes of blocks. Confidences of content-based block and image annotation are then obtained. On the other hand, spatial features by combining the block annotation confidence and the spatial context are proposed for main concepts, corresponding to the concepts been annotated, and the auxiliary concepts, corresponding to the concepts that have high co-occurrence with the main concepts in the images. This proposed spatial feature can incorporate the position of the concept and the spatial context between these concepts. Experiments on expanded Corel dataset categories demonstrate the effectiveness of the proposed method.
The genome sequence of Propionibacterium acidipropionici provides insights into its biotechnological and industrial potential (2019)

Abstract Background Synthetic biology allows the development of new biochemical pathways for the production of chemicals from renewable sources. One major challenge is the identification of suitable microorganisms to hold these pathways with sufficient robustness and high yield. In this work we analyzed the genome of the propionic acid producer Actinobacteria Propionibacterium acidipropionici (ATCC 4875). Results The assembled P. acidipropionici genome has 3,656,170 base pairs (bp) with 68.8%&#8201;G&#8201;+&#8201;C content and a low-copy plasmid of 6,868&#8201;bp. We identified 3,336 protein coding genes, approximately 1000 more than P. freudenreichii and P. acnes, with an increase in the number of genes putatively involved in maintenance of genome integrity, as well as the presence of an invertase and genes putatively involved in carbon catabolite repression. In addition, we made an experimental confirmation of the ability of P. acidipropionici to fix CO2, but no phosphoenolpyruvate carboxylase coding gene was found in the genome. Instead, we identified the pyruvate carboxylase gene and confirmed the presence of the corresponding enzyme in proteome analysis as a potential candidate for this activity. Similarly, the phosphate acetyltransferase and acetate kinase genes, which are considered responsible for acetate formation, were not present in the genome. In P. acidipropionici, a similar function seems to be performed by an ADP forming acetate-CoA ligase gene and its corresponding enzyme was confirmed in the proteome analysis. Conclusions Our data shows that P. acidipropionici has several of the desired features that are required to become a platform for the production of chemical commodities: multiple pathways for efficient feedstock utilization, ability to fix CO2, robustness, and efficient production of propionic acid, a potential precursor for valuable 3-carbon compounds.
Blueberry-Enriched Diet Protects Rat Heart from Ischemic Damage (2009)

A blueberry-enriched diet protected the myocardium from induced ischemic damage and demonstrated the potential to attenuate the development of post MI chronic heart failure.
Fast pediatric 3D free‐breathing abdominal dynamic contrast enhanced MRI with high spatiotemporal resolution (2013)

Purpose To develop a method for fast pediatric 3D free‐breathing abdominal dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) and investigate its clinical feasibility. Materials and Methods A combined locally low rank parallel imaging method with soft gating is proposed for free‐breathing DCE MRI acquisition. With Institutional Review Board (IRB) approval and informed consent/assent, 23 consecutive pediatric patients were recruited for this study. Free‐breathing DCE MRI with ∼1 mm 3 spatial resolution and a 6.5‐sec frame rate was acquired on a 3T scanner. Undersampled data were reconstructed with a compressed sensing method without motion correction (FB‐CS) and the proposed method (FB‐LR). A follow‐up respiratory‐triggered acquisition (RT‐CS) was performed as a reference standard. The reconstructed images were evaluated independently by two radiologists. Wilcoxon tests were performed to test the hypothesis that there was no significant difference between different reconstructions. Quantitative evaluation of contrast dynamics was also performed. Results The mean score of overall image quality of FB‐LR was 4.0 on a 5‐point scale, significantly better ( P &lt; 0.05) than FB‐CS reconstruction (mean score 2.9), and similar to RT‐CS (mean score 4.1). FB‐LR also matched the temporal fidelity of contrast dynamics with a root mean square error less than 5%. Conclusion Fast 3D free‐breathing DCE MRI with high scan efficiency and image quality similar to respiratory‐triggered acquisition is feasible in a pediatric clinical setting. J. Magn. Reson. Imaging 2015;41:460–473. © 2013 Wiley Periodicals, Inc .
Streaming From the Air : Enabling Drone-Sourced Video Streaming Applications on 5G Open-RAN Architectures (2021)

Enabling high data-rate uplink cellular connectivity for drones is a challenging problem, since a flying drone has a higher likelihood of having line-of-sight propagation to base stations that terrestrial UEs normally do not have line-of-sight to. This may result in uplink inter-cell interference and uplink performance degradation for the neighboring ground UEs when drones transmit at high data-rates (e.g., video streaming). We address this problem from a cellular operator’s standpoint to support drone-sourced video streaming of a point of interest. We propose a low-complexity, closed-loop control system for Open-RAN architectures that jointly optimizes the drone’s location in space and its transmission directionality to support video streaming and minimize its uplink interference impact on the network. We prototype and experimentally evaluate the proposed control system on a dedicated outdoor multi-cell RAN testbed, which is the first measurement campaign of its kind. Furthermore, we perform a large-scale simulation assessment of the proposed control system using the actual cell deployment topologies and cell load profiles of a major US cellular carrier. The proposed Open-RAN control scheme achieves an average <inline-formula><tex-math notation="LaTeX">$19\%$</tex-math></inline-formula> network capacity gain over traditional BS-constrained control solutions and satisfies the application data-rate requirements of the drone (e.g., to stream an HD video).
Euler characteristic of the bifurcation set for a polynomial of degree 2 or 3 (2010)

Assume that the coefficients of a polynomial in a complex variable are Laurent polynomials in some complex parameters. The parameter space (a complex torus) splits into strata corresponding to different combinations of coincidence of the roots of the polynomial. For generic Laurent polynomials with fixed Newton polyhedra the Euler characteristics of these strata are also fixed. We provide explicit formulae for the Euler characteristics of the strata in terms of the polyhedra of the Laurent polynomials in the cases of degrees 2 and 3. We also obtain some corollaries in combinatorial geometry, which follows from two different ways of computing the Euler characteristic of the bifurcation set for a reduced polynomial of degree 2.
Crowd scene understanding with coherent recurrent neural networks (2016)

Exploring crowd dynamics is essential in understanding crowd scenes, which still remains as a challenging task due to the nonlinear characteristics and coherent spatio-temporal motion patterns in crowd behaviors. To address these issues, we present a Coherent Long Short Term Memory (cLSTM) network to capture the nonlinear crowd dynamics by learning an informative representation of crowd motions, which facilitates the critical tasks in crowd scene analysis. By describing the crowd motion patterns with a cloud of keypoint tracklets, we explore the nonlinear crowd dynamics embedded in the tracklets with a stacked LSTM model, which is further improved to capture the collective properties by introducing a coherent regularization term; and finally, we adopt an unsupervised encoder-decoder framework to learn a hidden feature for each input tracklet that embeds its inherent dynamics. With the learnt features properly harnessed, crowd scene understanding is conducted effectively in predicting the future paths of agents, estimating group states, and classifying crowd events. Extensive experiments on hundreds of public crowd videos demonstrate that our method is state-of-the-art performance by exploring the coherent spatio-temporal structures in crowd behaviors.
New technique for degenerate two-photon absorption spectral measurements using femtosecond continuum generation (2002)

We present a new technique for direct measurements of degenerate two-photon absorption (TPA) spectra of two-photon absorbing materials including non-fluorescent samples. This technique is based on the use of an intense single continuum-generation beam as the coherent whitelight source with specially flattened spectral distribution. The different spectral components of the continuum beam are spatially dispersed and then passed through the sample material along different pathways so that nondegenerate TPA processes among different input spectral components can be avoided. By comparing the input and transmitted continuum spectral distributions, the TPA spectrum for a given sample can be obtained. As an example, the continuous TPA spectrum (from 550 to 1000 nm) is measured for a novel two-photon-absorbing compound (AF-389) which exhibits an extremely high TPA cross-section value of ~1x10-20 cm4/GW, or ~249 GM, around ~800-nm spectral range in femtosecond regime.
Convergence for Translation: Drug‐Delivery Research in Multidisciplinary Teams (2018)

The void between drug discovery and successful translation to humans is vast. In order to develop effective solutions, convergence of a multidisciplinary team with a range of expertise is required. In this Essay, examples of successful sustained delivery systems for antimalarials and antiretrovirals, as well as to the gastrointestinal tract are discussed.
Synthesis of Lipoteichoic Acids in Bacillus anthracis (2012)

Lipoteichoic acid (LTA), a glycerol phosphate polymer, is a component of the envelope of Gram-positive bacteria that has hitherto not been identified in Bacillus anthracis, the causative agent of anthrax. LTA synthesis in Staphylococcus aureus and other microbes is catalyzed by the product of the ltaS gene, a membrane protein that polymerizes polyglycerol phosphate from phosphatidyl glycerol. Here we identified four ltaS homologues, designated ltaS1 to -4, in the genome of Bacillus anthracis. Polyglycerol phosphate-specific monoclonal antibodies were used to detect LTA in the envelope of B. anthracis strain Sterne (pXO1(+) pXO2(-)) vegetative forms. B. anthracis mutants lacking ltaS1, ltaS2, ltaS3, or ltaS4 did not display defects in growth or LTA synthesis. In contrast, B. anthracis strains lacking both ltaS1 and ltaS2 were unable to synthesize LTA and exhibited reduced viability, altered envelope morphology, aberrant separation of vegetative forms, and decreased sporulation efficiency. Expression of ltaS1 or ltaS2 alone in B. anthracis as well as in other microbes was sufficient for polyglycerol phosphate synthesis. Thus, similar to S. aureus, B. anthracis employs LtaS enzymes to synthesize LTA, an envelope component that promotes bacterial growth and cell division.
ChemInform Abstract: COLLOIDAL REDOX CATALYSTS FOR OXYGEN GENERATION AND LIGHT‐INDUCED HYDROGEN GENERATION FROM WATER (1979)

Abstract Kolloidales Ruthenium(oxid) und andere kolloidale Metalle katalysieren Reaktionen wie z.B. A und B besser als die entsprechenden Makrodispersionen.