gebhart/patrepeval huggingface dataset:
Dynamic Allocation of Backhaul Resources for Distributed Interference Subtraction (2017)

This article explores a method to dynamically size the backhaul links (shared resources) used to support cooperative decoding and to forward decoded data, in the case of limited bandwidth of the backhaul. The practical approach provides a scheduler with a mean to know the backhaul limitations and to use it adequately while interacting with a traffic engineering optimizer which reacts to changes in demands of the radio access network balancing where to allocate cooperative backhaul resources to maximize fairness and throughput of users.
CARDIAC RESYNCHRONISATION THERAPY IN HEART FAILURE ATRIO-BIVENTRIKULARNA ELEKTROSTIMULACIJA SRCA PRI SRČNEM POPUŠČANJU (2005)

Cardiac resynchronisation therapy (CRT) is a new therapeutic approach for a selected group of patients with symptomatic heart failure (NYHA III-IV) despite optimal medical therapy, due to dilated cardiomyopathy of any etiology (LVEF≤ 35%, and LVEDD≥ 55 mm), who present with electro-mechanical dyssynchrony (QRS≥ 120 msec). Safety and effectiveness of CRT have been demonstrated by several clinical trials, with patients achieving significant improve- ment in both clinical symptoms as well as functional status and exercise capacity. Furthermore, CRT has reduced morbidity and mortality of heart failure patients. Whether or not heart failure patients candidate to CRT should receive a defibrillator (ICD) back-up remains debatable, although growing evidence is pointing to extensive use of a defibrilla- tor in such a population. Kljucne besede: kronicno srcno popuscanje; atrio-biventri- kularna elektrostimulacija srca; elektromehanicna dissinhro- nija; levokracni blok; kardioverter defibrilator Izvlecek - Atrio-biventrikularna elektrostimulacija srca (CRT) je nov nacin zdravljenja nekaterih bolnikov z izraže- nim srcnim popuscanjem (NYHA III-IV), ki se pojavi kljub ustre- znemu zdravljenju z zdravili. Vzrok dilatacijske kardiomio- patije ni pomemben (LVEF≤ 35%, in LVEDD≥ 55 mm), pac pa je pomembna elektromehanicna dissinhronija (QRS ≥ 120 ms). Varnost in ucinkovitost CRT so pokazale stevilne klinic- ne raziskave, kjer so ugotavljali izboljsanje klinicnih simpto- mov, fizikalnih parametrov kot tudi telesne zmogljivosti. Ugo- tovitve kažejo, da CRT zmanjsuje obolevnost in umrljivost pri bolnikih s srcnim popuscanjem. Ni se povsem jasno, ali naj bi bolniki, ki so kandidati za CRT, hkrati prejeli tudi kardiover- ter defibrilator (ICD), narasca pa stevilo dokazov, ki nedvo- mno podpirajo siroko uporabo ICD v tej populaciji bolnikov.
Efficacious Treatment of Experimental Leishmaniasis with Amphotericin B-Arabinogalactan Water-Soluble Derivatives (1999)

In this study, we tested the efficacy of amphotericin B (AmB)-arabinogalactan (AmB-AG) conjugates for the treatment of experimental leishmaniasis. Chemical conjugation of AmB to a water-soluble, biodegradable, and biocompatible polymer could present many advantages over presently available AmB formulations. Two conjugates were tested, a reduced (rAmB-AG) form and an unreduced (uAmB-AG) form. In vitro, the drug concentrations which lower the values of parasites (for promastigotes) or infected macrophages (for amastigotes) to 50% of the untreated values (ED(50)s) of uAmB-AG and rAmB-AG were 0.19 and 0.34 microg/ml, respectively, for Leishmania major promastigotes and 0.17 and 0.31 microg/ml, respectively, for amastigotes. The effect on Leishmania infantum-infected macrophages was more marked, with ED(50)s of 0.035 microg/ml for rAmB-AG and 0.027 microg/ml for uAmB-AG. In in vivo experiments, BALB/c mice injected with L. major were treated from day 2 onwards on alternate days for 2 weeks. Both conjugates, as well as liposomal AmB (all at 6 mg/kg of body weight) and Fungizone (1 mg/kg), significantly delayed the appearance of lesions compared to that in untreated mice. In addition, both conjugates, but not liposomal AmB, were significantly more effective than Fungizone. Subcutaneous injection of the conjugates (6 mg/kg) was significantly more effective than liposomal AmB in delaying the appearance of lesions. Higher AmB concentrations of up to 12 mg/kg could be administered by this route. When an established infection was treated, uAmB-AG was somewhat more effective than liposomal AmB. In summary, water-soluble polymeric AmB derivatives were found effective and safe for the treatment of leishmanial infections. The conjugates, which are stable and can be produced relatively cheaply (compared to lipid formulations), can be used in the future for the treatment of leishmaniasis infections.
Non-intrusive acoustic measurement of flow velocity and temperature in a high subsonic Mach number jet (2017)

In previous studies, sonic anemometry and thermometry have generally been used to measure low subsonic Mach flow conditions. Recently, a novel configuration was proposed and used to measure unheated jet velocities up to Mach 0.83 non-intrusively. The objective of this investigation is to test the novel configuration in higher temperature conditions and explore the effects of fluid temperature on mean velocity and temperature measurement accuracy. The current work presents non-intrusive acoustic measurements of single-stream jet conditions up to Mach 0.7 and total temperatures from 299 K to 700 K. Comparison of acoustically measured velocity and static temperature with probe data indicate root mean square (RMS) velocity errors of 2.6 m s−1 (1.1% of the maximum jet centerline velocity), 4.0 m s−1 (1.2%), and 8.5 m s−1 (2.4%), respectively, for 299, 589, and 700 K total temperature flows up to Mach 0.7. RMS static temperature errors of 7.5 K (2.5% of total temperature), 8.1 K (1.3%), and 23.3 K (3.3%) were observed for the same respective total temperature conditions. To the authors' knowledge, this is the first time a non-intrusive acoustic technique has been used to simultaneously measure mean fluid velocity and static temperatures in high subsonic Mach numbers up to 0.7. Overall, the findings of this work support the use of acoustics for non-intrusive flow monitoring. The ability to measure mean flow conditions at high subsonic Mach numbers and temperatures makes this technique a viable candidate for gas turbine applications, in particular.
The Soliton-Self-Frequency Shift in Passively Modelocked Soliton Fiber Lasers (1994)

Modelocked lasers are typically subject to a variety of instabilities that affect the quality of the output pulses. Particularly noticeable effects arise from the discreteness of the cavity elements [1] and third-order dispersion, which in turn lead to the formation of spectral side bands [2] and an asymmetric pulse spectrum [3] . However, any gain-pulling from these instabilities is minimal and therefore the spectrum of the modelocked pulses remains located close to the peak of the gain profile.
Forward Behavioral Modeling of a Three-Way Amplitude Modulator-Based Transmitter Using an Augmented Memory Polynomial (2018)

Reconfigurable and multi-standard RF front-ends for wireless communication and sensor networks have gained importance as building blocks for the Internet of Things. Simpler and highly-efficient transmitter architectures, which can transmit better quality signals with reduced impairments, are an important step in this direction. In this regard, mixer-less transmitter architecture, namely, the three-way amplitude modulator-based transmitter, avoids the use of imperfect mixers and frequency up-converters, and their resulting distortions, leading to an improved signal quality. In this work, an augmented memory polynomial-based model for the behavioral modeling of such mixer-less transmitter architecture is proposed. Extensive simulations and measurements have been carried out in order to validate the accuracy of the proposed modeling strategy. The performance of the proposed model is evaluated using normalized mean square error (NMSE) for long-term evolution (LTE) signals. NMSE for a LTE signal of 1.4 MHz bandwidth with 100,000 samples for digital combining and analog combining are recorded as -36.41 dB and -36.9 dB, respectively. Similarly, for a 5 MHz signal the proposed models achieves -31.93 dB and -32.08 dB NMSE using digital and analog combining, respectively. For further validation of the proposed model, amplitude-to-amplitude (AM-AM), amplitude-to-phase (AM-PM), and the spectral response of the modeled and measured data are plotted, reasonably meeting the desired modeling criteria.
Surgeon perceptions regarding custom-fit positioning technology for total knee arthroplasty. (2010)

Recently, studies have begun to assess the use of custom-fit arthroplasty sytsems that use magnetic resonance imaging to determine component placement. The purpose of this study was to assess how commonly this new technique is being used by surgeons and whether they perceive any benefits to their patients and/or to their practices. Fifty orthopaedic surgeons responded to a 19-question survey regarding custom-fit positioning total knee arthroplasty as part of a regional orthopaedic meeting. Overall, 10 of the 50 surgeons surveyed reported using custom-fit positioning technology. Of the remaining questionnaire participants, 29 of 40 indicated that they were interested in trying the new technique. The two reasons that were most frequently cited by the surgeons who were not interested in adopting the technique were costs and not enough clinical outcomes reports. The results of the present study suggest that if additional clinical studies at longer-term follow-up support these findings, then more surgeons may adopt this technique. Although cost was a perceived barrier to using this technique, the results of this survey suggest that some surgeons who use this technique may have reduced procedure time.
Realized Metamaterial CRLH Bandpass Filter for UHF-Band WLAN with Harmonics Suppressed (2008)

This paper presents the design of a size-reduced Bandpass Filter working in the UHF band. To minimize the overall size of the component, the concept of Left-Handedness is adopted and combined with Right-handed lines for using the resonators as small as around one eighth of a quarter-wavelength as well as suppressing higher ordered harmonics. In addition to the basic metamaterial theory, the inverters are included and implemented for C-coupling. This design method is validated by the physical realization as well as rigorous simulations.
Conformational studies of metal chelates. I. Intra-ring strain in five- and six-membered chelate rings (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformational studies of metal chelates. I. Intra-ring strain in five- and six-membered chelate ringsLouis J. DeHayes and Daryle H. BuschCite this: Inorg. Chem. 1973, 12, 7, 1505–1513Publication Date (Print):July 1, 1973Publication History Published online1 May 2002Published inissue 1 July 1973https://pubs.acs.org/doi/10.1021/ic50125a009https://doi.org/10.1021/ic50125a009research-articleACS PublicationsRequest reuse permissionsArticle Views209Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
D1 Dopamine Receptors of NS20Y Neuroblastoma Cells Are Functionally Similar to Rat Striatal D1 Receptors (1991)

Dopamine or agonists with D1 receptor potency stimulated cyclic AMP (cAMP) accumulation in whole cell preparations of NS20Y neuroblastoma cells. The accumulation of cAMP after D1 stimulation was rapid and linear for 3 min. Both dopamine and the novel D1 receptor agonist dihydrexidine stimulated cAMP accumulation two- to three-fold over baseline. The pseudo-Km for dopamine was approximately 2 microM, whereas for dihydrexidine it was approximately 30 nM. The effects of both drugs were blocked by either the D1-selective antagonist SCH23390 (Ki, 0.3 nM) or the nonselective antagonist (+)-butaclamol (Ki, 5 nM). Both (-)-butaclamol and the D2-selective antagonist (-)-sulpiride were ineffective (Ki greater than 3 microM). Forskolin (10 microM), prostaglandin E1 (1 microM), and adenosine (10 microM) also stimulated cAMP accumulation, but none were antagonized by SCH23390 (1 microM). Finally, muscarinic receptor stimulation (100 microM carbachol) inhibited both D1- and forskolin-stimulated increases in cAMP accumulation by 80%. The present results indicate that NS20Y neuroblastoma cells have D1 receptors that are coupled to adenylate cyclase, and that these receptors have a pharmacological profile similar to that of the D1 receptor(s) found in rat striatum.
Efficient computational models for optical nanowires (2010)

In this paper we utilize phenomenological models based on a Lorentz-Drude damped oscillator for describing the optical properties of an arbitrary solid. A computationally efficient method of including these constitutive parameters in a full-wave electromagnetic solver is presented through the use of equivalent circuit models and integral equations. These models can be represented as equivalent electric circuits which can be simulated with both frequency-domain and time-domain EFIE formulations. Integral equation solvers using these models are very efficient in terms of memory and time in comparison with other full-wave solvers such as the FDTD method. It is demonstrated that nanowires at near infrared and the lower part of the visible spectrum can be accurately simulated with integral equations.
B cell repertoire sequencing of HIV-1 pediatric elite-neutralizers identifies multiple broadly neutralizing antibody clonotypes (2023)

ABSTRACT A limited subset of HIV-1 infected adult individuals typically after at least 2-3 years of chronic infection, develop broadly neutralizing antibodies (bnAbs), suggesting that highly conserved neutralizing epitopes on the HIV-1 envelope glycoprotein are difficult for B cell receptors to effectively target, during natural infection. Recent studies have shown the evolution of bnAbs in HIV-1 infected infants. We used bulk BCR sequencing (BCR-seq) to profile the B cell receptors from longitudinal samples (3 time points) collected from a rare pair of antiretroviral-naïve, HIV-1 infected pediatric monozygotic twins (AIIMS_329 and AIIMS_330) who displayed elite plasma neutralizing activity against HIV-1. BCR-seq of both twins revealed convergent antibody characteristics including V-gene use, CDRH3 lengths and somatic hypermutation (SHM). Further, antibody clonotypes with genetic features similar to highly potent bnAbs isolated from adults showed ongoing development in donor AIIMS_330 but not in AIIMS_329, corroborating our earlier findings based on plasma bnAbs responses. An increase in SHM was observed in sequences of the IgA isotype from AIIMS_330. This study suggests that children living with chronic HIV-1 can develop clonotypes of HIV-1 bnAbs against multiple envelope epitopes similar to those isolated from adults, highlighting that such B cells could be steered to elicit bnAbs responses through vaccines aimed to induce bnAbs against HIV-1 in a broad range of people including children.
High threshold voltage in GaN MOS-HEMTs modulated by fluorine plasma and gate oxide (2013)

AlGaN/GaN high-electron-mobility transistors (HEMTs) have great potential for the next generation of power electronics. In this application, enhancement-mode (E-mode) metal-oxide-semiconductor (MOS) HEMTs with a threshold voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> ) ~ 3 V are highly desirable as they allow simpler circuits and fail-safe operation. However, it has been recently shown that the V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> in GaN MOS-HEMT structures does not typically increase by increasing the gate oxide thickness, due to the presence of positive interface charges and oxide bulk charges [1]. On the other hand, a high V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> was reported in fluorinated MOS-HEMTs (~5 V) [2], although no analysis or explanation have been presented for this behavior. There is, therefore, a need for a systematic study of the V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> in fluorinated MOS-HEMTs. In this work, E-mode fluorinated MOS-HEMTs were realized with a V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> higher than 3 V and a V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> increasing with the gate oxide thickness and fluorine plasma time. A comprehensive analytical model for V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> was proposed for fluorinated MOS-HEMTs for the first time and was verified by experimental data. Moreover, fluoride-induced negative bulk charge inside the oxide layer was demonstrated to significantly contribute to the high V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> . This suggests that the fluorine plasma treatment is a promising technique to facilitate a high V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> for E-mode MOS-HEMTs.
Using Unnatural Amino Acid Mutagenesis To Probe the Regulation of PRMT1 (2013)

Protein arginine methyltransferase 1 (PRMT1)-dependent methylation contributes to the onset and progression of numerous diseases (e.g., cancer, heart disease, ALS); however, the regulatory mechanisms that control PRMT1 activity are relatively unexplored. We therefore set out to decipher how phosphorylation regulates PRMT1 activity. Curated mass spectrometry data identified Tyr291, a residue adjacent to the conserved THW loop, as being phosphorylated. Natural and unnatural amino acid mutagenesis, including the incorporation of p-carboxymethyl-l-phenylalanine (pCmF) as a phosphotyrosine mimic, were used to show that Tyr291 phosphorylation alters the substrate specificity of PRMT1. Additionally, p-benzoyl-l-phenylalanine (pBpF) was incorporated at the Tyr291 position, and cross-linking experiments with K562 cell extracts identified several proteins (e.g., hnRNPA1 and hnRNP H3) that bind specifically to this site. Moreover, we also demonstrate that Tyr291 phosphorylation impairs PRMT1's ability to bind and methylate both proteins. In total, these studies demonstrate that Tyr291 phosphorylation alters both PRMT1 substrate specificity and protein-protein interactions.
Characterization of Novel Selective H1-Antihistamines for Clinical Evaluation in the Treatment of Insomnia (2009)

Analogues of the known H(1)-antihistamine R-dimethindene were profiled as potential agents for the treatment of insomnia. Several highly selective compounds were efficacious in rodent sleep models. On the basis of overall profile, indene 1d and benzothiophene 2a had pharmacokinetic properties suitable for evaluation in night time dosing. Compound 2a did not show an in vivo cardiovascular effect from weak hERG channel inhibition.
Improved para‐Xylene Selectivity in meta‐Xylene Isomerization Over ZSM‐5 Crystals with Relatively Long b‐Axis Length (2013)

Abstract ZSM‐5 zeolite crystals with controllable b‐ axis length (sheet‐like, S‐ZSM‐5; chain‐like, C‐ZSM‐5) have been synthesized by using urea and starch as additives in the starting aluminosilicate gels. X‐ray diffraction (XRD) patterns and scanning electron microscopy (SEM) images show that these zeolite samples have good crystallinity. Transmission electron microscopy (TEM) images show that there is a strong chemical interaction between the stacked crystals in C‐ZSM‐5 samples. N 2 sorption isotherms indicate that C‐ZSM‐5 crystals are mesoporous. Catalytic tests for the formation of p ‐xylene from m‐ xylene isomerization show that, compared with other zeolite catalysts, C‐ZSM‐5 catalysts give both high conversion and improved p ‐xylene selectivity, which are attributed to the combination of relatively long b ‐axis length and the present mesoporosity in the crystals. The improvement of p ‐xylene selectivity in catalytic m‐ xylene isomerisation is of great importance for selective industrial production of p ‐xylene in the future.
Feasibility study on single-port access (SPA) laparoscopic cholecystectomy using transanal endoscopic microsurgery (TEM) instruments (2010)

Transanal endoscopic microsurgery (TEM) is a procedure for the treatment of rectal villous adenoma and early rectal tumours. It is actually the first single port access surgery (SPA) as well as a true Natural Orifice Transluminal Endoscopic Surgery (NOTES) in standard use for the last twenty years. The use of this technique and instrumentation in cholecystectomy is revisited. A feasibility study was done on porcine model. Peri-umbilical approach with the articulated TEM instruments was used for cholecystectomy. An in vivo study was started after the successful feasibility study. Cholecystectomy was performed on three consecutive porcine models using TEM instruments. Median operation time was 26.6 min. The post-op mean wound length was 3.7 cm. One gallbladder was perforated during the operation and the others were delivered intact. The instrument length was noted and the difficulty in instrument handling was documented. SPA cholecystectomy is feasible with Transanal Endoscopic Microsurgery (TEM) instruments. The special TEM technique of manipulation within a confined space is ideal for single port surgery. The TEM rectoscope can be used as a reusable single port and the instruments can be used as well but modification is suggested.
Surface-stabilized holograms in azo-dye doped nematic liquid crystals (1992)

We record polarization holograms in 1 % methyl red doped PCB liquid crystals by using the trans isomer absorption of the azo dye at 514 nm. The hologram is probed at 633 nm. Holographic dynamics are determined by the surface treatment of the glass substrate. In the unexposed sample, the liquid crystal molecular director is aligned by surface forces. Surface memory plays a crucial role in the holographic effects we observe. Using the Ericksen–Leslie theory, we derive the characteristic time constant for dynamic hologram formation and decay. The erasing time depends on the grating spatial frequency. It varies from 4 ms to 60 ms as we change the writing angles from 9° to 1.5°. Photochemical isomerization in a nematic liquid crystal host drives reorientation dynamics of the liquid crystal molecules either by a simple splay and twist in competition with the surface stabilized planar alignment or by triggering an isothermal phase transition from the nematic to isotropic. The Freedericksz threshold intensity is found to be about 3.0 mW/cm 2 .