gebhart/patrepeval huggingface dataset:
4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]- piperazinyl]-6,7-dimethoxyquinazoline (L-765,314):  A Potent and Selective α1b Adrenergic Receptor Antagonist (1998)

ADVERTISEMENT RETURN TO ISSUELetterNEXT4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]- piperazinyl]-6,7-dimethoxyquinazoline (L-765,314): A Potent and Selective α1b Adrenergic Receptor AntagonistMichael A. Patane, Ann L. Scott, Theodore P. Broten, Raymond S. L. Chang, Richard W. Ransom, Jerry DiSalvo, Carlos Forray, and Mark G. BockView Author Information Departments of Medicinal Chemistry, Cardiovascular Pharmacology, and New Lead Pharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, Biochemistry and Physiology Department, Merck & Co., Inc., Rahway, New Jersey 07065, and Synaptic Pharmaceutical Corp., 215 College Road, Paramus, New Jersey 07652 Cite this: J. Med. Chem. 1998, 41, 8, 1205–1208Publication Date (Web):March 19, 1998Publication History Received23 January 1998Published online19 March 1998Published inissue 1 April 1998https://pubs.acs.org/doi/10.1021/jm980053fhttps://doi.org/10.1021/jm980053frapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views590Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Antagonists,Inhibition,Receptors,Rodent models,Selectivity Get e-Alerts
Direct Spatial Implementation of Sparse Matrix Multipliers for Reservoir Computing (2022)

Reservoir computing is a nascent sub-field of machine learning which relies on the recurrent multiplication of a very large, sparse, fixed matrix. We argue that direct spatial implementation of these fixed matrices minimizes the work performed in the computation, and allows for significant reduction in latency and power through constant propagation and logic minimization. Bit-serial arithmetic enables massive static matrices to be implemented. We present the structure of our bit-serial matrix multiplier, and evaluate using canonical signed digit representation to further reduce logic utilization. We have implemented these matrices on a large FPGA and provide a cost model that is simple and extensible. These FPGA implementations, on average, reduce latency by 50x up to 86x versus GPU libraries. Comparing against a recent sparse DNN accelerator, we measure a 4.1x to 47x reduction in latency depending on matrix dimension and sparsity.
GPS bistatic radar measurements of aircraft altitude and ground objects with a software receiver (2005)

The GPS bistatic radar concept exploits the differences between direct and ground reflected signals received from one or more GPS satellites to aid in navigation or for remote sensing of the surface or transmission medium. This paper provides an overview of an implementation of the technique using a MATLAB-based software receiver and presents example results from an overland flight test. The sample data set was collected during a twenty minute segment of a flight test performed with a NASA Gulfstream V on 20-August-2004. Raw GPS data samples were recorded at 16 MHz from zenith- and nadirpointing GPS antennas through a custom RF front end and data logger. These samples were post-processed using C/A code software GPS receiver techniques. The bistatic radar measurements are converted to a height above ground level and reflected signal-to-noise ratio. The height measurements are found to follow the trends computed based on receiver solved for height and digital elevations. Signal power is highly correlated with ground type with water returns producing the highest power reflections followed by large man made objects.
Supplemental Video 2 from Visualization of Activated T Cells by OX40-ImmunoPET as a Strategy for Diagnosis of Acute Graft-versus-Host Disease (2023)

&lt;p&gt;Day7_GVHD&lt;/p&gt;
Aggregating Continuous Word Embeddings for Information Retrieval (2013)

While words in documents are generally treated as discrete entities, they can be embedded in a Euclidean space which reflects an a priori notion of similarity between them. In such a case, a text document can be viewed as a bag-ofembedded-words (BoEW): a set of realvalued vectors. We propose a novel document representation based on such continuous word embeddings. It consists in non-linearly mapping the wordembeddings in a higher-dimensional space and in aggregating them into a documentlevel representation. We report retrieval and clustering experiments in the case where the word-embeddings are computed from standard topic models showing significant improvements with respect to the original topic models. 1
Self-Management Support Using Advertising Principles for Older Adults With Low Income at High Cardiovascular Risk: A Randomized Controlled Trial (2023)

gov; Unique identifier: NCT02579655.
The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome (2016)

Most cases of severe influenza are associated with pulmonary complications, such as acute respiratory distress syndrome (ARDS), and no antiviral drugs of proven value for treating such complications are currently available. The use of monoclonal antibodies targeting the stem of the influenza virus surface hemagglutinin (HA) is a rapidly developing strategy for the control of viruses of multiple HA subtypes. However, the mechanisms of action of these antibodies are not fully understood, and their ability to mitigate severe complications of influenza has been poorly studied. We evaluated the effect of treatment with VIS410, a human monoclonal antibody targeting the HA stem region, on the development of ARDS in BALB/c mice after infection with influenza A(H7N9) viruses. Prophylactic administration of VIS410 resulted in the complete protection of mice against lethal A(H7N9) virus challenge. A single therapeutic dose of VIS410 given 24 h after virus inoculation resulted in dose-dependent protection of up to 100% of mice inoculated with neuraminidase inhibitor-susceptible or -resistant A(H7N9) viruses. Compared to the outcomes in mock-treated controls, a single administration of VIS410 improved viral clearance from the lungs, reduced virus spread in lungs in a dose-dependent manner, resulting in a lower lung injury score, reduced the extent of the alteration in lung vascular permeability and protein accumulation in bronchoalveolar lavage fluid, and improved lung physiologic function. Thus, antibodies targeting the HA stem can reduce the severity of ARDS and show promise as agents for controlling pulmonary complications in influenza.
Phase I Randomized Clinical Trial of VRC DNA and rAd5 HIV-1 Vaccine Delivery by Intramuscular (IM), Subcutaneous (SC) and Intradermal (ID) Administration (VRC 011) (2014)

Clinicaltrials.gov NCT00321061.
Phonon group velocity and thermal conduction in superlattices (1999)

With the use of a face-centered cubic model of lattice dynamics we calculate the group velocity of acoustic phonons in the growth direction of periodic superlattices. Comparing with the case of bulk solids, this component of the phonon group velocity is reduced due to the flattening of the dispersion curves associated with Brillouin-zone folding. The results are used to estimate semiquantitatively the effects on the lattice thermal conductivity in Si/Ge and GaAs/AlAs superlattices. For a Si/Ge superlattice an order of magnitude reduction is predicted in the ratio of superlattice thermal conductivity to phonon relaxation time [consistent with the results of P. Hyldgaard and G. D. Mahan, Phys. Rev. B 56, 10 754 (1997)]. For a GaAs/AlAs superlattice the corresponding reduction is rather small, i.e., a factor of 2--3. These effects are larger for the superlattices with larger unit period, contrary to the recent measurements of thermal conductivity in superlattices.
Retardation of 20%Cr Steel Oxidation with Laves Phase Precipitation (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
A topological encoding convolutional neural network for segmentation of 3D multiphoton images of brain vasculature using persistent homology (2020)

The clinical evidence suggests that cognitive disorders are associated with vasculature dysfunction and decreased blood flow in the brain. Hence, a functional understanding of the linkage between brain functionality and the vascular network is essential. However, methods to systematically and quantitatively describe and compare structures as complex as brain blood vessels are lacking. 3D imaging modalities such as multiphoton microscopy enables researchers to capture the network of brain vasculature with high spatial resolutions. Nonetheless, image processing and inference are some of the bottlenecks for biomedical research involving imaging, and any advancement in this area impacts many research groups. Here, we propose a topological encoding convolutional neural network based on persistent homology to segment 3D multiphoton images of brain vasculature. We demonstrate that our model out-performs state-of-the-art models in terms of the Dice coefficient and it is comparable in terms of other metrics such as sensitivity. Additionally, the topological characteristics of our model's segmentation results mimic manual ground truth. Our code and model are open source at https://github.com/mhaft/DeepVess.
Identification of White Spot Syndrome Virus Latency-Related Genes in Specific-Pathogen-Free Shrimps by Use of a Microarray (2003)

To investigate whether specific-pathogen-free (SPF) shrimps are asymptomatic carriers of white spot syndrome virus (WSSV), we used a WSSV-specific DNA microarray to measure WSSV gene expression in SPF and WSSV-infected shrimps. Three WSSV genes were found to be relatively highly expressed in SPF shrimps. Reverse transcription-PCR using nested primers as well as real-time detection confirmed that these genes have no detectable counterparts in GenBank; structural analysis of the putative proteins revealed helix-loop-helix and leucine zipper motifs. Viral sequences could be PCR amplified from genomic DNA of SPF shrimp, further supporting the suggestion that these shrimps are asymptomatic carriers.
Performance Evaluations of Transmit Diversity Schemes with Synchronization Signals for LTE Downlink (2015)

This paper presents the effect of transmit diversity on the initial and neighboring cell search time performance and the most appropriate transmit diversity scheme based on system-level simulations employing synchronization signals for the Long Term Evolution (LTE) downlink. The synchronization signals including the primary synchronization signal (PSS) and secondary synchronization signal (SSS) are the first physical channel that a set of user equipment (UE) acquires at the initial radio-link connection. The transmit diversity candidates assumed in the paper are Precoding Vector Switching (PVS), Cyclic Delay Diversity (CDD), Time Switched Transmit Diversity (TSTD), and Frequency Switched Transmit Diversity (FSTD), which are all suitable for simple blind detection at a UE. System-level simulation results show that transmit diversity is effective in improving the detection probabilities of the received PSS timing and PSS sequence in the first step and those of the SSS sequence and radio frame timing in the second step of the cell search process. We also show that PVS achieves fast cell search time performance of less than approximately 20ms at the location probability of 90% regardless of the inter-cell site distance up to 10km. Hence, we conclude that PVS is the best transmit diversity scheme for the synchronization signals from the viewpoint of decreasing the initial and neighboring cell search times.
Novel Design of Carbon-Rich Polymers for 193 nm Microlithography: Adamantane-Containing Cyclopolymers (2000)

For 193 nm lithographic applicationsrobust polymers containing a high carbon/hydrogen ratio are required. In this paper a novel cyclopolymerization approach is presented for producing chemically amplified resists that are transparent at the imaging wavelength. Upon exposure to a 193 nm laser stepper, features 160 nm in size can readily be obtained (see Fig.).
Stereoselective epoxidation of electron poor dienes using poly(L-leucine) (1997)

Poly(L-leucine) catalysed oxidation of dienes 2, 3, 10, 16 and 18 and the triene 17 furnishes the corresponding epoxides 4, 5, 11, 19, 21 and 20 respectively in good to excellent yield and in states of high optical purity. Some regioselective reactions of the saturated epoxy ketones 5 and 11 are described.
Identification of Human Kinases Involved in Hepatitis C Virus Replication by Small Interference RNA Library Screening (2007)

The propagation of the hepatitis C virus (HCV) is a complex process that requires both host and viral proteins. To facilitate identification of host cell factors that are required for HCV replication, we screened a panel of small interference RNAs that preferentially target human protein kinases using an HCV replicon expressing the firefly luciferase gene as a genetic reporter. Small interference RNAs specific for three human kinases, Csk, Jak1, and Vrk1, were identified that reproducibly reduce viral RNA and viral protein levels in HCV replicon-bearing cells. Treatment of replicon cells with a small molecule inhibitor of Csk also resulted in a significant reduction in HCV RNA and proteins, further supporting a role for Csk in HCV replication. The effects of siRNAs targeting eight kinases known to be negatively regulated by Csk were then examined; knock down of one of these kinases, Fyn, resulted in up-regulation of the HCV replicon, suggesting that Csk mediates its effect on HCV replication through Fyn. This conclusion was further corroborated by demonstration that replicon cells treated with Csk inhibitor contained lower levels of the phosphorylated form of Fyn than control cells.
Observation of Single Molecule Plasmon-Driven Electron Transfer in Isotopically Edited 4,4′-Bipyridine Gold Nanosphere Oligomers (2017)

We clarify mechanistic questions regarding plasmon-driven chemistry and nanoscale photocatalysis within optically confined near-field plasmonic systems. Using surface-enhanced Raman scattering (SERS), we directly monitor the photoinduced reaction dynamics of 4,4'-bipyridine molecules, localized in plasmonic hot spots within individual gold nanosphere oligomers. Our experiment generates surface electrons from the gold nanoparticle using an intense off-molecular resonance continuous wave pump field, and detects radical anion products via SERS. This is done by adopting a dual-wavelength spectroscopic approach. Empirical evidence of plasmon-driven electron transfer is provided for the first time by direct detection of the 4,4'-bipyridine radical anion species localized in the plasmonic hot spots of individual gold nanosphere oligomers, corroborated by open-shell density functional theory calculations. An isotopologue approach using both protonated and deuterated 4,4'-bipyridine molecules demonstrates the single molecule response of plasmon-driven electron transfer occurring in single nanosphere oligomer systems with a 3% yield, a phenomenon unobserved in ensemble measurements under analogous experimental conditions. This mechanism has broad applicability to using nanoscale chemical reactors for surface redox reactions on the subnanometer scale.
The first hour experience (2014)

The first time a player sits down with a game is critical for their engagement. Games are a voluntary activity and easy to abandon. If the game cannot hold player attention, it will not matter how much fun the game is later on if the player quits early. Worse, if the initial experience was odious enough, the player will dissuade others from playing. Industry advice is to make the game fun from the start to hook the player. In our analysis of over 200 game reviews and interviews with industry professionals, we advance an alternative, complementary solution. New design terminology is introduced such as "holdouts" (what keeps players playing despite poor game design) and the contrast between momentary fun vs. intriguing experiences. Instead of prioritizing fun, we assert that intrigue and information should be seen as equally valuable for helping players determine if they want to continue playing. The first sustained play session (coined "first hour"), when inspected closely, offers lessons for game development and our understanding of how players evaluate games as consumable products.
Film Bulk Acoustic Resonator using High-Acoustic-Impedance Electrodes (2007)

A bulk acoustic wave filter composed of piezoelectric thin-film resonators has many features superior to those of other small filters such as a surface acoustic wave (SAW) filter and a ceramic filter. A high-Q factor and low loss are big advantages for a film bulk acoustic resonator (FBAR). The electrode material that is selected is very important for maintaining a high-Q and appropriate coupling factor. An analysis of the effects of acoustic impedance on AlN-based FBAR performance is described. The electromechanical coupling factor (k2) and filter loss were found to be influenced by acoustic impedance and to be mainly dominated by Young's modulus. Ru was found by analysis and experiments to be a suitable material for the electrode. Finally, a 2 GHz wide band code division multiple access (WCDMA) filter was demonstrated to have a good performance.
A high performance 256K TTL SRAM using 0.8um triple diffused BiCMOS with 3V circuit techniques (1991)

If BiCMOS technology is going to be successfully used to improve the performance of logic circuits in future technology generations, BiCMOS circuit designs will need to offer similar performance advantages over CMOS at 3.3V supply as they do at 5V. This paper describes a 0.8mum BiCMOS 256K TTL SRAM that maintains its performance over a comparable CMOS SRAM when the supply voltage is lowered to 3.3V.
Structure in Tethered Chains:  Polymeric Micelles and Chains Anchored on Polystyrene Latex Spheres (1998)

The star models are briefly summarized and used to explain the layer thickness of the soluble block of polystyrene-poly(ethylene oxide) (PS−PEO) diblock copolymer micelles in water and cyclopentane. Both the discrete blob model (DB) and the distribution density (DD) model describe well the tethered layer of the soluble block. The structure and thickness of the adlayer formed by adsorption of the PS−PEO diblock copolymer micelles onto PS lattices is strongly dependent on the radius of the latex particle and the length of the PEO block. The star model is adequate for a latex of 32 nm radius and long PEO blocks (N = 445 and 480), but deviates for smaller PEO chains (N = 148), where the adlayer thickness is well predicted by the planar brush model. This planar brush model is still valid for a latex of 54 nm radius and the same PEO chain. For longer chains and/or larger lattices, neither model correctly predicts the adlayer thickness because of the disruption of the micelles during their adsorption process. This disruption results in the formation of loops and trains on the PS surface that make the subsequent adsorption of more micelles and the formation of a dense adlayer difficult.
Time-to-digital converters based on RSFQ digital counters (1997)

We have designed, fabricated, and successfully tested a Time-to-Digital converter (TDC). The TDC circuit consists of superconductive counters based on toggle flip-flops with destructive readout, shift registers, parallel-to-serial converters, and pulse detectors. The value of the counter is latched while the counter is operating at full speed. The TDC resolution is directly determined by the maximum counter speed, or 50 ps for an available 20 GHz clock rate. The circuits are implemented in HYPRES' standard Nb process with a critical current density of 1.0 kA/cm/sup 2/ using HYPRES' library of standard RSFQ cells.
Predictors of intensive care unit admission and mortality in SARS-CoV-2 infection: A cross sectional study at a tertiary care hospital (2022)

Certain inflammatory and coagulopathy markers, and having certain lung radiological features, in addition to having medical comorbidities, specifically, ischemic heart disease and renal impairment are key predictors for serious morbidity and mortality in patients infected with COVID-19. These should be incorporated into medical institutes risk assessment tools used by physicians and policy makers to instigate, prioritize, and reprioritize care in patients with COVID-19 and instigate preventative strategy to reduce the impact of future outbreak.
Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550) (2008)

Here, we examine the significance that stereochemistry plays within the clinically relevant Janus kinase 3 (Jak3) inhibitor 1 (CP-690,550). A synthesis of all four enantiopure stereoisomers of the drug was carried out and an examination of each compound revealed that only the enantiopure 3R,4R isomer was capable of blocking Stat5 phosphorylation (Jak3 dependent). Each compound was profiled across a panel of over 350 kinases, which revealed a high level of selectivity for the Jak family kinases for these related compounds. Each stereoisomer retained a degree of binding to Jak3 and Jak2 and the 3R,4S and 3S,4R stereoisomers were further revealed to have binding affinity for selected members of the STE7 and STE20 subfamily of kinases. Finally, an appraisal of the minimum energy conformation of each stereoisomer and molecular docking at Jak3 was performed in an effort to better understand each compounds selectivity and potency profiles.
Omnidirectional Reflector with Total Internal Reflective Interface for Light Extraction Enhancement of Solid‐State Light Source (Phys. Status Solidi A 5∕2019) (2019)

Solid-State Light Source In article number 1700775 Kazuyuki Yamae, Hiroshi Fukshima, and Kozo Fujimoto develop novel omnidirectional reflector with total internal reflective interface (TI-ODR) which realizes higher reflectance compared to conventional reflector for solid-state light source (SSL). The authors then fabricate the TI-ODR onto a gallium nitride (GaN) - based light emitting device (LED) and obtain a light extraction efficiency enhancement factor of approximately 1.1.