gebhart/patrepeval huggingface dataset:
Spectroscopic and magnetic studies of iron(III) phosvitins (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectroscopic and magnetic studies of iron(III) phosvitinsJohn Webb, Jagir S. Multani, Paul Saltman, Nancy A. Beach, and Harry B. GrayCite this: Biochemistry 1973, 12, 9, 1797–1802Publication Date (Print):April 24, 1973Publication History Published online1 May 2002Published inissue 24 April 1973https://pubs.acs.org/doi/10.1021/bi00733a021https://doi.org/10.1021/bi00733a021research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Perfect Tracking Control based on Prediction of Reference for High Speed Optical Disc System (2007)

This paper proposes a high-performance robust tracking control system for next-generation optical disc system. The proposed tracking control system consists of robust feedback control system and perfect tracking control system based on error-prediction. The proposed robust feedback control system has a good performance of sudden disturbance suppression for improving a free parameter. Moreover, the periodic-disturbance suppression performance of error-prediction feedforward control system is improved by using zero phase low-pass filter (ZPLPF), in comparison with the conventional control approaches. The experimental results point out that the proposed tracking control system has a precise tracking response against both the periodic disturbance and the sudden disturbance.
Computational Enhancement of Molecularly Targeted Contrast-Enhanced Ultrasound: Application to Human Breast Tumor Imaging (2020)

Molecularly targeted contrast enhanced ultrasound (mCEUS) is a clinically promising approach for early cancer detection through targeted imaging of VEGFR2 (KDR) receptors. We have developed computational enhancement techniques for mCEUS tailored to address the unique challenges of imaging contrast accumulation in humans. These techniques utilize dynamic analysis to distinguish molecularly bound contrast agent from other contrast-mode signal sources, enabling analysis of contrast agent accumulation to be performed during contrast bolus arrival when the signal due to molecular binding is strongest. Applied to the 18 human patient examinations of the first-in-human molecular ultrasound breast lesion study, computational enhancement improved the ability to differentiate between pathology-proven lesion and pathology-proven normal tissue in real-world human examination conditions that involved both patient and probe motion, with improvements in contrast ratio between lesion and normal tissue that in most cases exceed an order of magnitude (10x). Notably, computational enhancement eliminated a false positive result in which tissue leakage signal was misinterpreted by radiologists to be contrast agent accumulation.
Early assessment of therapy response in small cell lung cancer via longitudinal ctDNA analysis. (2018)

8577 Background: From the prospective, observational German Lung Cancer Multi-Marker Study we selected the first 72 consecutive small-cell lung cancer (SCLC) patients, UICC-stage IIIB/IV, where plasma samples were available prior to start of therapy, and prior to the second cycle of chemotherapy, and prior to third cycle. We hypothesized that assessment of the level of ctDNA after starting therapy relates to treatment effect and prognosis. Methods: We employed AVENIO ctDNA Surveillance Kit, a 197-gene NGS assay, which allowed us to perform longitudinal ctDNA analysis and measure the mutant molecules per milliliter-of-plasma (MMPM), which quantifies ctDNA over all variants of all sequenced genomic regions. All extracted cfDNA samples were processed and sequenced in order of date of blood draw. Results: At baseline (b0), we identified variants in all (72/72) subjects to enable ctDNA monitoring. Using serial liquid biopsies from each subject, the mean MMPM at post-first treatment cycle (p1) and the mean MMPM at post-second treatment cycle (p2) were analyzed. We tested a Continuous Responder algorithm, defined by a continuous drop in ctDNA levels represented by mean MMPM reduction over time (p2 < p1 < b0), to a mean MMPM below 20 at p2. As a result, continuous responders 26/72 were associated with a better therapy response OS HR = 1.9 (95% CI 1.1 – 3.2, log-rank P = 0.015). The continuous responders demonstrated a median survival benefit of 4.4 months over the poor responders. Neither gender, nor age, nor ECOG, nor stage were predictors of response in the models. Conclusions: An early assessment of treatment effect can be measured by mutant molecule counts in the plasma. A decrease in post-treatment ctDNA levels was associated with better prognosis in advanced SCLC.
Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family (1998)

We have previously described the antibacterial capacity of protegrin-1 (PG-1), a cysteine-rich, cationic peptide from porcine leukocytes, against Neisseria gonorrhoeae. We now report genetic and biochemical evidence that gonococcal susceptibility to the lethal action of PG-1 and other structurally unrelated antibacterial peptides, including a peptide (LL-37) that is expressed constitutively by human granulocytes and testis and inducibly by keratinocytes, is modulated by an energy-dependent efflux system termed mtr. These results indicate that such efflux systems may enable mucosal pathogens like gonococci to resist endogenous antimicrobial peptides that are thought to act during infection.
Interstitial lung abnormalities in the AGES-Reykjavik study (2016)

<b>Background:</b> Interstitial lung abnormalities (ILA) have been associated with physiologic and genetic abnormalities but these associations, and the association between ILA and mortality, have not been previously evaluated in older adults. <b>Objectives:</b> To explore the associations between important predictors and outcomes of ILA in a cohort of older adults from the Age/Gene Environment Susceptibility (AGES) Reykjavik Study. <b>Methods:</b> ILA were visually assessed in chest CT scans from 5,320 AGES-Reykjavik participants. <b>Results:</b> ILA were present in 378 (7%), 1726 (32%) had indeterminate ILA status and 3216 (61%) had no ILA. Compared to those without ILA, those with ILA were more likely to be older and male, and had increased tobacco smoke exposure. After adjustment for covariates, ILA were also associated with an increased risk of all-cause mortality (Hazard Ratio 1.3, 95% CI 1.2-1.4, P&lt;0.0001). The increased rate of mortality was explained by an increased rate of death due to respiratory disease, specifically pulmonary fibrosis. Additionally, after adjustment for covariates ILA was associated with increasing copies of the minor allele the <i>MUC5B</i> promoter polymorphism (odds ratio [OR] 2.7, 95% Confidence Interval [CI] 2.2, 3.2, P&lt;.0001). The <i>MUC5B</i> promoter polymorphism was independently associated with all subtypes of ILA with the exception of those characterized by centrilobular nodules alone. <b>Conclusions:</b> Comparable to previous studies, those with ILA in the AGES-Reykjavik, were more likely to be older, to have increased tobacco exposure, and to have increasing copies of the minor allele of the <i>MUC5B</i> promoter polymorphism. Older adults with ILA in the AGES-Reykjavik had an increased rate of mortality.
Data from Validation of the 12-gene Predictive Signature for Adjuvant Chemotherapy Response in Lung Cancer (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Response to adjuvant chemotherapy after tumor resection varies widely among patients with non–small cell lung cancer (NSCLC); therefore, it is of clinical importance to prospectively predict who will benefit from adjuvant chemotherapy before starting the treatment. The goal of this study is to validate a 12-gene adjuvant chemotherapy predictive signature developed from a previous study using a clinical-grade assay.&lt;/p&gt;Experimental Design:&lt;p&gt;We developed a clinical-grade assay for formalin-fixed, paraffin-embedded (FFPE) samples using the NanoString nCounter platform to measure the mRNA expression of the previously published 12-gene set. The predictive performance was validated in a cohort of 207 patients with early-stage resected NSCLC with matched propensity score of adjuvant chemotherapy.&lt;/p&gt;Results:&lt;p&gt;The effects of adjuvant chemotherapy were significantly different in patients from the predicted adjuvant chemotherapy benefit group and those in the predicted adjuvant chemotherapy nonbenefit group (&lt;i&gt;P&lt;/i&gt; = 0.0056 for interaction between predicted risk group and adjuvant chemotherapy). Specifically, in the predicted adjuvant chemotherapy benefit group, the patients receiving adjuvant chemotherapy had significant recurrence-free survival (RFS) benefit (HR = 0.34; &lt;i&gt;P&lt;/i&gt; = 0.016; adjuvant chemotherapy vs. nonadjuvant chemotherapy), while in the predicted adjuvant chemotherapy nonbenefit group, the patients receiving adjuvant chemotherapy actually had worse RFS (HR = 1.86; &lt;i&gt;P&lt;/i&gt; = 0.14; adjuvant chemotherapy vs. nonadjuvant chemotherapy) than those who did not receive adjuvant chemotherapy.&lt;/p&gt;Conclusions:&lt;p&gt;This study validated that the 12-gene signature and the FFPE-based clinical assay predict that patients whose resected lung adenocarcinomas exhibit an adjuvant chemotherapy benefit gene expression pattern and who then receive adjuvant chemotherapy have significant survival advantage compared with patients whose tumors exhibit the benefit pattern but do not receive adjuvant chemotherapy.&lt;/p&gt;&lt;/div&gt;
Susceptibility of eSTREAM Candidates towards Side Channel Analysis (2008)

We analyze the relevant candidates in phase 3 of the eSTREAM project with respect to side channel analysis in a theoretical approach.
Investigation on optimum frequency bandwidth allocation method among service channels for system throughput maximization (2017)

In the fifth generation mobile communication systems, various wireless communication services such as massive machine-type communications (mMTC), ultra-reliable low latency communications (URLLC), and enhanced mobile broadband (eMBB) will be supported. The physical channels (service channels) dedicated to these respective wireless communication services will be multiplexed in a shared system frequency band and these services will have different requirements regarding spectrum efficiency and fairness among terminals. Therefore, appropriate frequency bandwidth assignment to each service channel considering the service requirement, number of terminals, and their channel conditions for all wireless communication services is important to maximize the system performance. In this paper, we define different forms of system throughput for the respective service channels considering different service requirements. Based on a definition of the integrated system throughput that combines the system throughput levels of all service channels, this paper proposes the optimum frequency bandwidth allocation method among service channels to maximize the integrated system throughput. Computer simulation results show the effectiveness of the proposed method.
A Quadrature Balanced Multi-Mode RF Front-End Architecture with Wideband Ultra Low Power Self Interference Cancellation (2019)

This paper presents a quadrature balanced RF Front-End architecture with a built-in primary isolation for a single antenna Full Duplex and Time Division Duplex wireless communications. Self-interference cancellation is implemented by injecting a digitally synthesized cancellation signal into a dedicated input port that enables wideband cancellation of the leaking transmit signal at the receiver. A closed form analytical expression of the cancellation signal as a function of the channel frequency response is derived, together with a nonlinear analysis that predicts distortion fundamentals at both transmit and receive channels. Simulations at the 5-6GHz Wi-Fi band verify the theoretical results and demonstrate leakage cancellation better than 60dB for 160MHz and 320MHz channels for linear and nonlinear operation conditions.
Attachment of trianglamines to silicon wafers, chiral recognition by chemical force microscopy (2010)

The chemical attachment of enantiomerically pure trianglamines to silicon wafers through isocyanate functions was performed. The self-assembled monolayer was analyzed by ATR-FTIR, ellipsometry, AFM, contact angle measurements. An AFM tip was functionalized by enantiomerically pure trianglamine using the same pathway. Chemical force microscopy showed chiral recognition between the functionalized tip and the functionalized wafer.
Multicast Content Delivery for Mobiles (2004)

The delivery of content to many users simultaneously using a shared multicast transport path and last mile is attractive for several reasons. More efficient use of infrastructure and radio bandwidth is very important to mobile wireless network operators, especially since higher data rate rich-media services are made feasible without increasing the total network capacity. Users benefit from consuming shared content both in technical terms - higher data rates and faster downloads - and social terms - content demand increasingly correlates to common interests for persistent communities and dynamic ad hoc groups. Two recent initiatives are on the track of progressing through development, standardization and commercialization, which are IP Datacast (IPDC) and Multimedia Broadcast Multicast Services (MBMS). Although these originate from different backgrounds - digital television and radio broadcast, and 3rd generation cellular telecommunications respectively - they both hold the promise of providing true multipoint services to mobile and wireless users, with all the benefits and opportunities that this brings.
Proton assisted recoupling and protein structure determination (2008)

We introduce a homonuclear version of third spin assisted recoupling, a second-order mechanism that can be used for polarization transfer between (13)C or (15)N spins in magic angle spinning (MAS) NMR experiments, particularly at high spinning frequencies employed in contemporary high field MAS experiments. The resulting sequence, which we refer to as proton assisted recoupling (PAR), relies on a cross-term between (1)H-(13)C (or (1)H-(15)N) couplings to mediate zero quantum (13)C-(13)C (or (15)N-(15)N recoupling). In particular, using average Hamiltonian theory we derive an effective Hamiltonian for PAR and show that the transfer is mediated by trilinear terms of the form C(1) (+/-)C(2) (-/+)H(Z) for (13)C-(13)C recoupling experiments (or N(1) (+/-)N(2) (-/+)H(Z) for (15)N-(15)N). We use analytical and numerical simulations to explain the structure of the PAR optimization maps and to delineate the PAR matching conditions. We also detail the PAR polarization transfer dependence with respect to the local molecular geometry and explain the observed reduction in dipolar truncation. Finally, we demonstrate the utility of PAR in structural studies of proteins with (13)C-(13)C spectra of uniformly (13)C, (15)N labeled microcrystalline Crh, a 85 amino acid model protein that forms a domain swapped dimer (MW=2 x 10.4 kDa). The spectra, which were acquired at high MAS frequencies (omega(r)2pi>20 kHz) and magnetic fields (750-900 MHz (1)H frequencies) using moderate rf fields, exhibit numerous cross peaks corresponding to long (up to 6-7 A) (13)C-(13)C distances which are particularly useful in protein structure determination. Using results from PAR spectra we calculate the structure of the Crh protein.
Author response: Spreading of a mycobacterial cell-surface lipid into host epithelial membranes promotes infectivity (2020)

Applying bioorthogonal chemistry to the zebrafish/Mycobacterium marinum model of tuberculosis reveals that the virulence lipid PDIM must spread into epithelial cells in order for mycobacteria to establish infection.
The Biology of Integration of Cells into Microscale and Nanoscale Systems (2004)

In chapter 5 we focused on the informational interface between cells and synthetic components of systems. This interface is concerned with facilitating and manipulating information transport and processing between and within the synthetic and whole-cell components of these hybrid systems. However, there is also a structural interface between these components that is concerned with the physical placement, entrapment, and maintenance of the cells in a manner that enables the informational interface to operate. In this chapter we focus on this structural interface. Successful integration of whole-cell matrices into microscale and nanoscale elements requires a unique environment that fosters continued cell viability while promoting, or at least not blocking, the information transport and communication pathways described in earlier chapters. A century of cell culture has provided a wealth of insight and specific protocols to maintain the viability and (typically) proliferation of virtually every type of organism that can be propagated. More recently, the demands for more efficient bioreactors, more compatible biomedical implants, and the promise of engineered tissues has driven advances in surface-modification sciences, cellular immobilization, and scaffolding that provide structure and control over cell growth, in addition to their basic metabolic requirements. In turn, hybrid biological and electronic systems have emerged, capable of transducing the often highly sensitive and specific responses of cellular matrices for biosensing in environmental, medical, and industrial applications. The demands of these systems have driven advances in cellular immobilization and encapsulation techniques, enabling improved interaction of the biological matrix with its environment while providing nutrient and respiratory requirements for prolonged viability of the living matrices. Predominantly, such devices feature a single interface between the bulk biomatrix and transducer. However, advances in lithography, micromachining, and micro-/nanoscale synthesis provide broader opportunities for interfacing whole-cell matrices with synthetic elements. Advances in engineered, patterned, or directed cell growth are now providing spatial and temporal control over cellular integration within microscale and nanoscale systems. Perhaps the best defined integration of cellular matrices with electronically active substrates has been accomplished with neuronal patterning. Topographical and physicochemical patterning of surfaces promotes the attachment and directed growth of neurites over electrically active substrates that are used to both stimulate and observe excitable cellular activity.
飞行时间-电感耦合等离子体质谱法测定钢、镍基合金及锆锡合金中痕量元素 (2007)

在微波辅助系统中对屑状的样品进行湿法消解，采用飞行时间电感耦合等离子体质谱测定钢、镍基合金及锆锡合金中9种痕量和超痕量元素元素。所建立的工作曲线的线性跨度达多个数量级。对一些稀有元素如Ga，Ta，Ir，Pt和，U和较常见的元素如Sn，Sb，Pb和Bi一起进行测定，检测的含量范围从0．046μg／g（锆锡合金中的U）至45μg／g（低合金钢中的Sn），并测定了镍基合金中的微量元素Sn。对于所分析的样品中μg／g级和次-μg／g级的元素，获得了较好的精密度和准确度。
Sweet Biotechnology: Enzymatic Production and Digestibility Screening of Novel Kojibiose and Nigerose Analogues (2022)

In view of the global pandemic of obesity and related metabolic diseases, there is an increased interest in alternative carbohydrates with promising physiochemical and health-related properties as a potential replacement for traditional sugars. However, our current knowledge is limited to only a small selection of carbohydrates, whereas the majority of alternative rare carbohydrates and especially their properties remain to be investigated. Unraveling their potential properties, like digestibility and glycemic content, could unlock their use in industrial applications. Here, we describe the enzymatic production and <i>in vitro</i> digestibility of three novel glycosides, namely, two kojibiose analogues (<i>i.e</i>., d-Glc<sub>p</sub>-α-1,2-d-Gal and d-Glc<sub>p</sub>-α-1,2-d-Rib) and one nigerose analogue (<i>i.e</i>., d-Glc<sub>p</sub>-α-1,3-l-Ara). These novel sugars were discovered after an intensive acceptor screening with a sucrose phosphorylase originating from <i>Bifidobacterium adolescentis</i> (BaSP). Optimization and upscaling of this process led to roughly 100 g of these disaccharides. Digestibility, absorption, and caloric potential were assessed using brush border enzymes of rat origin and human intestinal Caco-2 cells. The rare disaccharides showed a reduced digestibility and a limited impact on energy metabolism, which was structure-dependent and even more pronounced for the three novel disaccharides in comparison to their respective glucobioses, translating to a low-caloric potential for these novel rare disaccharides.
Supplementary Tables 1-2 from MicroRNA Alterations of Pancreatic Intraepithelial Neoplasias (2023)

&lt;p&gt;PDF file - 3.7MB&lt;/p&gt;
Investigation of Current Gain in Superconducting-Ferromagnetic Transistors With High-j ${}_{\rm c}$ Acceptor (2016)

We report the results of a study of the current gain in high Josephson critical current density (j <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> ) superconducting-ferromagnetic transistors with the SISFIFS structure [where S, I, and F denote a superconductor (Nb), an insulator (AlO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</sub> ), and a ferromagnetic material (permalloy, Py), respectively]. The Nb/AlOx/Nb trilayer, which serves as the acceptor (SIS) junction, is estimated to have Josephson critical current density j <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> of 19 kA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The Al/Py/Al/AlO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</sub> /Py/Al/Nb multilayer is deposited in a separate vacuum run after in situ ion milling of about 8 nm of the top Nb layer. The devices are patterned using optical lithography and tested at 4.2 K. We have observed a small-signal current gain in the range of 5-9. We demonstrate that proper device engineering allows one to efficiently control the maximum Josephson current in the SISF acceptor junction using the quasiparticle injection.