MP82-16 SFI-UTUC, A NOVEL BASED MORPHOMETRIC SCORING SYSTEM FOR UPPER TRACT UROTHELIAL CELL CARCINOMA: PREDICTING SURVIVAL AND RECURRENCE OUTCOMES (2020)

You have accessJournal of UrologyBladder Cancer: Upper Tract Transitional Cell Carcinoma II (MP82)1 Apr 2020MP82-16 SFI-UTUC, A NOVEL BASED MORPHOMETRIC SCORING SYSTEM FOR UPPER TRACT UROTHELIAL CELL CARCINOMA: PREDICTING SURVIVAL AND RECURRENCE OUTCOMES Devin Patel*, Fady Ghali, Nathan Miller, Sunil Patel, Margaret Meagher, Raksha Dutt, Zachary Hamilton, Vitaly Margulis, Robert Uzzo, and Ithaar Derweesh Devin Patel*Devin Patel* More articles by this author , Fady GhaliFady Ghali More articles by this author , Nathan MillerNathan Miller More articles by this author , Sunil PatelSunil Patel More articles by this author , Margaret MeagherMargaret Meagher More articles by this author , Raksha DuttRaksha Dutt More articles by this author , Zachary HamiltonZachary Hamilton More articles by this author , Vitaly MargulisVitaly Margulis More articles by this author , Robert UzzoRobert Uzzo More articles by this author , and Ithaar DerweeshIthaar Derweesh More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000974.016AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Upper tract urothelial cell carcinoma (UTUC) is an uncommon malignancy with disparate outcomes. We developed a novel pre-operative morphometric scoring system for predicting outcomes following nephroureterectomy (NU). METHODS: Retrospective, multicenter analysis of patients who underwent NU for UTUC after negative metastatic workup. Preoperative CT-urography was used to evaluate scores on 3 factors (Tumor Size, Focality, Invasion of architecture) with a score of 1-3 based on degree of each factor (total score 3-9). Primary outcome was overall survival (OS). Secondary outcome was recurrence free survival (RFS). Multivariable (MVA) and Kaplan-Meier (KMA) analyses were utilized. RESULTS: Of 244 patients analyzed, 61% had SFI-UTUC score 3-6 and 39% had score 7-9. No difference in age, gender, comorbid conditions, surgical approach, or complications was seen between groups. Score 7-9 had a higher rate of pT4 (14.7 vs. 2.7%; p=0.001) and pN+ (24.2 vs. 8.1%, p=0.002) disease but similar grade and lymphovascular invasion. OS was worse for score 7-9 (28.9 vs 47.4%; p=0.004) and remained significant on MVA. KMA for OS demonstrated 5-year OS of 57.0% for score 3-6 and 34.1% for score 7-9 (p<0.01). KMA for RFS was significant for renal pelvis UTUC location with 5-year RFS of 72.3% for score 3-6 and 54.2% for score 7-9, (p<0.01). CONCLUSIONS: A novel scoring system for UTUC preoperative imaging may predict OS for tumors in renal and ureteral locations, as well as RFS UTUC located in the renal pelvis. Source of Funding: Stephen Weissman Kidney Cancer Research Fund © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1252-e1253 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Devin Patel* More articles by this author Fady Ghali More articles by this author Nathan Miller More articles by this author Sunil Patel More articles by this author Margaret Meagher More articles by this author Raksha Dutt More articles by this author Zachary Hamilton More articles by this author Vitaly Margulis More articles by this author Robert Uzzo More articles by this author Ithaar Derweesh More articles by this author Expand All Advertisement PDF downloadLoading ...