gebhart/patrepeval huggingface dataset:
Crystal structure analysis of an osmium(VI) bisglycolate produced by reaction of a sterically hindered chiral nonracemic alkene with osmium tetroxide (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal structure analysis of an osmium(VI) bisglycolate produced by reaction of a sterically hindered chiral nonracemic alkene with osmium tetroxideMatthew R. Sivik, Judith C. Gallucci, and Leo A. PaquetteCite this: J. Org. Chem. 1990, 55, 1, 391–393Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/jo00288a079https://doi.org/10.1021/jo00288a079research-articleACS PublicationsRequest reuse permissionsArticle Views240Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Personnel Training in Pharmaceutical Manufacturing (2007)

This chapter contains sections titled: Overview Developing a Training Plan: Strategy to Ensure Training Compliance in a Pharmaceutical Manufacturing Facility References
Stochastic Bit-Wise Iterative Decoding of Polar Codes (2019)

Polar codes have received recent attention due to their potential to be applied in advanced wireless communication protocols such as the fifth generation mobile communication system (5G). Among the existing decoding algorithms, Belief Propagation (BP) exhibits high-throughput, low-latency, and soft output with a high hardware cost. Stochastic computing, as a form of approximate computing, provides a potential low-cost implementation solution for the BP algorithm. However, existing stochastic BP decoders suffer from a relatively long decoding latency resulting in low hardware efficiency. In this paper, a novel bit-wise iterative stochastic decoding architecture for the BP algorithm is proposed to improve the throughput and hardware efficiency. By utilizing the frozen bits of polar codes and stochastic computing, multiple novel optimization methods are presented to further speed up convergence and increase the hardware efficiency.
A Distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis (2010)

New neurons are continuously added throughout life to the dentate gyrus of the mammalian hippocampus. During embryonic and early postnatal development, the dentate gyrus is formed in an outside-in layering pattern that may extend through adulthood. In this work, we sought to quantify systematically the relative position of dentate granule cells generated at different ages. We used 5'-bromo-2'-deoxyuridine (BrdU) and retroviral methodologies to birth date cells born in the embryonic, early postnatal, and adult hippocampus and assessed their final position in the adult mouse granule cell layer. We also quantified both developmental and adult-born cohorts of neural progenitor cells that contribute to the pool of adult progenitor cells. Our data confirm that the outside-in layering of the dentate gyrus continues through adulthood and that early-born cells constitute most of the adult dentate gyrus. We also found that substantial numbers of the dividing cells in the adult dentate gyrus were derived from early-dividing cells and retained BrdU, suggesting that a subpopulation of hippocampal progenitors divides infrequently from early development onward.
Targeted Mass Spectrometry of a Clinically Relevant PSA Variant from Post‐DRE Urines for Quantitation and Genotype Determination (2020)

The study demonstrates that MS based peptide variant quantitation in urine could be useful in determining patient genotype expression. This assay provides a tool to evaluate the utility of PSA variant (rs17632542) in parallel with current and forthcoming urine biomarker panels.
Memory optimization in single chip network switch fabrics (2002)

Moving high bandwidth (10Gb/s+) network switches from the large scale, rack mount design space to the single chip design space requires a re-evaluation of the overall design requirements. In this paper, we explore the design space for these single chip devices by evaluating the ITRS. We find that unlike ten years ago when interconnect was scarce, the limiting factor in today's designs is on-chip memory. We then discuss an architectural technique for maximizing the effectiveness of queue memory in a single chip switch. Next, we show simulation results that indicate that a more than two order of magnitude improvement in dropped packet probability can be achieved by re-distributing memory and allowing sharing between the switch's ports. Finally, we evaluate the cost of the optimized architecture in terms of other on-chip resources.
Feeding point determination regarding hand effect of PIFA for mobile RFID band (2006)

In this paper, we considered variations of the antenna characteristic about PIFA for mobile RFID Band when we held the mobile phone. So we studied antenna characteristic by feeding point variation of antenna. After all, we determined that antenna gets different effects after compared antenna characteristic about hand effect of each feeding point and studied the results.
QoE model for video delivered over an LTE network using HTTP adaptive streaming (2014)

The end user quality of experience (QoE) of content delivered over a radio network is (mainly) influenced by the radio parameters in the radio access network. This paper will present a QoE model for video delivered over a radio network (e.g., Long Term Evolution (LTE)) using HTTP (Hypertext Transfer Protocol) adaptive streaming (HAS). The model is based on experiments performed in the context of the Next Generation Mobile Networks (NGMN) project P-SERQU (Project Service Quality Definition and Measurement). In the first phase, a set of representative HAS profiles were selected based on a lab experiment where scenarios with typical radio impairments (fading, signal-to-interference-plus-noise ratio, round trip time and competing traffic) were investigated in a test network. Based on these HAS profiles, video files were prepared by concatenating chunks of the corresponding video quality. In a second phase, these video files were downloaded, viewed, and rated by a large number of volunteers. Based on these user scores a mean opinion score (MOS) was determined for each of the video files, and hence, the HAS profiles. Several QoE models that predict the MOS from the HAS profile have been analyzed. Using the preferred QoE model, a range of MOS values can be obtained for each set of initial radio impairments. It is argued that a QoE model based on the radio parameters is necessarily less accurate than a QoE model based on HAS profiles and an indication is given of how much the performance of the former is less than the latter.
Self-selecting, self-tuning, incrementally optimized indexes (2010)

In a relational data warehouse with many tables, the number of possible and promising indexes exceeds human comprehension and requires automatic index tuning. While monitoring and reactive index tuning have been proposed, adaptive indexing focuses on adapting the physical database layout for and by actual queries.
The determination of the Pr valence state in (Pr1.5Ce0.5)Sr2Cu2NbO10 compound by Electron Energy Loss Spectroscopy (1995)

The debate on the Pr valence state in PrBCO compounds is well documented. Recently (Pr 1.5 Ce 0.5 )Sr 2 Cu 2 NbO 10 (RCeSCNO) system has been synthesized and studied. In this paper, the results of our study to determine the valence of Pr in PrCeSCNO, which has similar property of PrBCO are presented. Typical EELS spectrum of Pr M 45 edges with Ce M 45 edges from (Pr 1.5 Ce 0.5 )Sr 2 Cu 2 NbO 10 is shown in Fig. 1. In Fig. 1 the energy position of Ce M 45 edges were taken at 883.0 eV and 901.0 eV. The Ce M 45 edges were used to calibrate the energy axis, so that the position of Pr M 45 edges could be accurately measured. The measured energy positions of Pr M 45 edges in PrCeSCNO and in Pr 2 Ce 2 O 7 and Pr 2 Ce 2 O 8 , which were used to obtain the spectra of trivalent and tetravalent Pr compounds, are also listed in table 1. The spectra taken from these compounds are shown in Fig. 1 (a) and (b).
Cherenkov emission spectroscopy for tissue oxygen saturation assessment (2012)

Radiation from a linear accelerator induces Cherenkov emission in tissue. The absorption and scatter of this light imparts spectral changes which can be made quantitative through the use of standard spectroscopic techniques.
Scalable Parallel Computing Framework for Pump Scheduling Optimization (2009)

As multi-core personal computers (PC) have become popular and widely available for various computation tasks, developing parallel computing methods are imperative for taking the full capacity of the multi-core machines. This paper reports on the analysis and comparison of different paradigms for portable parallel computation on single multi-core PC and a cluster of PCs. It summarizes the strength and weakness of various parallel and distributed computation models. A scalable and portable parallel optimization framework has been developed and applied to water distribution pump scheduling to improve energy efficiency. It is implemented as a generic optimization method for hydraulic engineers to optimize the pump operation policy in order to maximize energy cost efficiency. An example study is presented to demonstrate the application of the parallel and distributed optimization model. The results show a linear speedup has been achieved for the parallel optimization of pump scheduling.
<title>UV photosensitivity in conventionally melted germano-silicate glasses</title> (2000)

The UV-photosensitivity effect in germania-doped optical waveguides has become an important area of research because of the ease and utility of making Bragg gratings. In this study we report on the finding of a large UV-induced refractive index change in a conventionally melted an alkali-alumino-boro-germano- silicate composition that has been loaded with molecular hydrogen. The exposure was done with either CW 244-nm light, or a pulsed KrF excimer laser at 248-nm. A modulated refractive index of the order of 2-3 X 10<SUP>-4</SUP> has been measured.
832 Pharmacokinetics and Exposure-Response Relationships of Ustekinumab in Patients With Ulcerative Colitis: Results From the UNIFI Induction and Maintenance Studies (2019)

INTRODUCTION: Serum concentrations of monoclonal antibody-based biologics have been shown to correlate with their efficacy. PK, exposure-response (ER), and immunogenicity of ustekinumab (UST) were evaluated in UNIFI induction and maintenance studies in UC. Induction results were presented previously. METHODS: PK, immunogenicity, efficacy &amp; safety data were obtained from induction and maintenance Phase 3, double-blind, PBO-controlled trials in adults with moderate-severe UC. Pts (n = 961) in the induction study received a single IV infusion at Wk0 of PBO, UST 130 mg, or UST ∼6 mg/kg UST. Responders to a single IV infusion of UST (n = 523) were randomly assigned to receive SC PBO, UST 90 mg q12w, or UST 90 mg q8w. Blood samples were collected to measure serum UST concentration and antibodies to ustekinumab. Relationships between serum UST concentrations &amp; efficacy measures, and safety outcomes were evaluated. RESULTS: Serum UST concentrations over time were dose proportional, unaffected by concomitant immunosuppressants, &amp; similar between pts who were biologic failures &amp; non-failures. Median peak serum UST concentrations in the induction study were 43.2 μg/mL &amp; 127.0 μg/mL for the 130 mg &amp; ∼6 mg/kg dose groups, respectively. At induction Wk8, median UST concentrations were 2.51 μg/mL &amp; 8.59 μg/mL, respectively. Steady-state was reached by the start of the second SC maintenance dose. Median steady-state trough serum UST concentrations over time in the UST q8w group (2.69 to 3.09 μg/mL) were 3-fold higher than in the q12w group (0.92 to 1.19 μg/mL). Serum UST concentrations were positively associated with response &amp; remission rates (Table 1), and there was an inverse association between serum UST concentrations and CRP and fecal calprotectin levels. No relationship was observed between serum UST concentrations &amp; the incidence of infections, serious infections or SAEs during induction or maintenance. 3.4% of pts receiving UST maintenance had antibodies to UST through 1 year using a drug-tolerant assay vs. 9.1% with PBO; no impact of antibodies on efficacy was observed. CONCLUSION: Serum UST concentrations were approx. dose-proportional. A positive ER of serum UST with clinical efficacy measures and an inverse relationship with inflammatory markers was observed during UST IV induction &amp; SC maintenance. Adverse events including infections did not increase with increased serum UST concentrations. These findings are consistent with those in UST for Crohn’s disease.
ChemInform Abstract: Cyclizations of Terminally Substituted a,c‐Biladiene Salts to Give meso‐Substituted Porphyrins. (1987)

Abstract Cyclizations of the a,c‐biladienes (I), (IV), (VI) under the conditions shown in the scheme yield the corresponding meso‐substituted porphyrins (IIa), (Va), or (VIIa) (after the removal of copper) along with small amounts of the corresponding unsubstituted analogues (IIb), (Vb), (VIIb).
Applicability and limitations of an M2Spice-assisted “planar-magnetics-in-the-circuit” simulation approach (2016)

Planar magnetics design for power electronics naturally involves many tradeoffs, especially in the selection of the core size, winding structure and printed circuit board stackup. “Magnetics-in-the-circuit” SPICE simulations can facilitate quick magnetics design evaluation and iteration. This paper introduces and evaluates a “planar-magnetics-in-the-circuit” simulation approach with an M2Spice software tool, which has been developed based on an earlier presented Modular Layer Model (MLM) analysis approach [1]. M2Spice converts the magnetics geometry into a SPICE netlist, which can be simulated with other circuit elements in a power converter under a unified setup. This paper presents an analysis of the applicability and limitations of this approach across wide frequency bands, followed by an evaluation of the accuracy of the SPICE simulation results (by comparing the simulation results to finite-element-modeling (FEM) results and experimental measurements). Multiple planar magnetics prototypes are designed, modeled, simulated, built, and measured, with results reported and discussed.
Energy Eﬃciency for Wireless Relay Systems (2012)

Climate change has been an important international agenda these days and will be more important in the future. A number of climate groups have been working on to reduce CO2 emissions. A climate group (called GeSI) has identiﬁed that information and communications technology (ICT) sectors can play a key role in reducing CO2 emissions by 15% in Smart 2020 report [1]. To reduce CO2 emissions, it is also important to provide energy eﬃcient solutions in wireless communications. In this chapter, we discuss energy eﬃciency for wireless relay systems. Energy eﬃciency can be measured by the energy consumed to transmit one bit over wireless channels. Depending on transmission schemes and system conﬁgurations, the energy eﬃciency can be diﬀerent and this measure helps choose a better scheme or system for information transmissions. We will focus on wireless relay systems and analyze their energy eﬃciency in terms of energy and delay tradeoﬀ (EDT). The notion of EDT plays a crucial role in deciding energy eﬃcient transmission schemes or systems with delay constraints as quality of service (QoS) constraints.
Isolation, Culture, and Transplantation of Muscle Satellite Cells (2014)

Muscle satellite cells are a stem cell population required for postnatal skeletal muscle development and regeneration, accounting for 2-5% of sublaminal nuclei in muscle fibers. In adult muscle, satellite cells are normally mitotically quiescent. Following injury, however, satellite cells initiate cellular proliferation to produce myoblasts, their progenies, to mediate the regeneration of muscle. Transplantation of satellite cell-derived myoblasts has been widely studied as a possible therapy for several regenerative diseases including muscular dystrophy, heart failure, and urological dysfunction. Myoblast transplantation into dystrophic skeletal muscle, infarcted heart, and dysfunctioning urinary ducts has shown that engrafted myoblasts can differentiate into muscle fibers in the host tissues and display partial functional improvement in these diseases. Therefore, the development of efficient purification methods of quiescent satellite cells from skeletal muscle, as well as the establishment of satellite cell-derived myoblast cultures and transplantation methods for myoblasts, are essential for understanding the molecular mechanisms behind satellite cell self-renewal, activation, and differentiation. Additionally, the development of cell-based therapies for muscular dystrophy and other regenerative diseases are also dependent upon these factors. However, current prospective purification methods of quiescent satellite cells require the use of expensive fluorescence-activated cell sorting (FACS) machines. Here, we present a new method for the rapid, economical, and reliable purification of quiescent satellite cells from adult mouse skeletal muscle by enzymatic dissociation followed by magnetic-activated cell sorting (MACS). Following isolation of pure quiescent satellite cells, these cells can be cultured to obtain large numbers of myoblasts after several passages. These freshly isolated quiescent satellite cells or ex vivo expanded myoblasts can be transplanted into cardiotoxin (CTX)-induced regenerating mouse skeletal muscle to examine the contribution of donor-derived cells to regenerating muscle fibers, as well as to satellite cell compartments for the examination of self-renewal activities.
WebDAVA: An administrator-free approach to Web file-sharing (2004)

Collaboration over the Internet depends on the ability of the members of a group to exchange data in a secure yet unobtrusive manner. WebDAVA is a system that allows the users to define their own access-control policies to network resources that they control, enabling secure data sharing within the enterprise. Our design allows users to selectively give fine-grain access to their resources without involving their system administrators. We accomplish this by using authorization credentials that define the users' privileges. Our prototype implements a file-sharing service, where users maintain sensitive-information folders and can allow others to access parts of these. Clients interact with the server over HTTP via a Java applet that transparently handles credential management. This mechanism allows users to share information with users not a priori known to the system, enabling administrator-free management.
Pitch-based emphasis detection for characterization of meeting recordings (2004)

The automatic extraction of key utterances in spoken data has emerged as an interesting and difficult topic in automatic speech recognition. "Emphasis" or "excitement" may be a useful identifier for these utterances of interest. We undertake the task of reliably and automatically identifying emphasized or excited utterances in natural speech in a meeting setting. We start by endeavoring to establish reliable ground truth emphasis labels by using several hand-labelers. The results show that human listeners can reliably identify emphasized utterances in meeting recordings. We then build an automatic emphasis detection system, which uses normalized pitch as its only acoustic predictor. The results show that this pitch-based emphasis detection scheme can distinguish between non-emphasized and emphasized utterances with an accuracy of 92% when ambiguous cases are excluded, a rate comparable to human interlabeler agreement.
A common variant in the 3′UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder (2008)

Underactivity of the glutamatergic system is an attractive model for the pathophysiology of several major mental illnesses. We previously described a chromosome abnormality disrupting the kainate class ionotropic glutamate receptor gene, GRIK4/KA1, in an individual with schizophrenia and learning disability (mental retardation). We also demonstrated in a case-control study that two physically separated haplotypes within this gene were significantly associated with increased risk of schizophrenia and decreased risk of bipolar disorder, respectively. The latter protective haplotype was located at the 3' end of the gene. We now report the identification from carriers of the protective haplotype of a deletion variant within the 3' untranslated region of the gene. The deletion allele also was found to be negatively associated with bipolar disorder in both initial (P = 0.00000019) and replication (P = 0.0107) case-control studies. Expression studies indicated that deletion-carrying mRNA transcripts were relatively more abundant. We postulate that this may be a direct consequence of the differences in the RNA secondary structures predicted for the insertion and deletion alleles. These data suggest a mechanism whereby the genetic protective effect is mediated through increased kainate receptor expression.
The Amino Acid Sequence of a Major Nonimmunoglobulin Component of Some Amyloid Fibrils (1972)

The complete amino acid sequence of a protein, acid soluble fraction, (ASF) which constitutes up to 50% of amyloid fibrils from a patient with familial Mediterranean fever has been obtained. Partial amino acid sequences of three other proteins from patients with secondary amyloidosis were identical in the regions studied except for an alanine-valine interchange in one. The ASF contains no cysteine, does not resemble any known immunoglobulin, and has not been detected as yet in myeloma-associated amyloid.
Preparation and Evaluation of Chitosan Microspheres Containing Bisphosphonates (1997)

Local implantation or injection of microspheres containing bisphosphonates for site-specific therapy may aid in treating several pathological conditions associated with bone destruction. Chitosan microspheres containing two antiresorption and anticalcification agents, pamidronate and suberoylbisphosphonate (SuBP), were prepared from a w/o emulsion. Various formulation variables were studied for their effect on the release rate profile of these bone-seeking agents. Polymer coating of micromatrices yielded microspheres with the most retarded release rate, and the drug delivery system was found biocompatible in endothelial cell culture. The microspheres were examined in vitro and in vivo for release kinetics and drug disposition. The release of bisphosphonate from the microspheres was faster in vitro than in vivo. Drug disposition following implantation of microspheres in the tibialis muscle resulted in a relatively increased disposition in the adjacent tibia while injection of drug solution in the tibialis muscle resulted in uniform disposition of the drug in the femorae and tibiae. Bisphosphonate released from chitosan microspheres effectively inhibited bioprosthetic tissue calcification in the rat subdermal model.