gebhart/patrepeval huggingface dataset:
An analytical diabolo model for robotic learning and control (2021)

In this paper, we present a diabolo model that can be used for training agents in simulation to play diabolo, as well as running it on a real dual robot arm system. We first derive an analytical model of the diabolo-string system and compare its accuracy using data recorded via motion capture, which we release as a public dataset of skilled play with diabolos of different dynamics. We show that our model outperforms a deep-learning-based predictor, both in terms of precision and physically consistent behavior. Next, we describe a method based on optimal control to generate robot trajectories that produce the desired diabolo trajectory, as well as a system to transform higher-level actions into robot motions. Finally, we test our method on a real robot system playing the diabolo, and throw it to and catch it from a human player.
Liquid jet impingement cooling of high-performance interposer packages: a hybrid CFD – FEM modeling study (2023)

Bare-die direct liquid jet impingement cooling is an efficient cooling technique that has been successfully applied with various materials including Si, ceramic, metal and plastics. In this paper, we assess the application of liquid jet impingement cooling for a 3D system-on-chip (SoC) interposer package for high performance computing applications (HPC) with a 26x26 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and 8 high-bandwidth memory modules (HBM-2e), using a modeling study based on experimentally validated thermal models. The simulation study shows that the local customization of the impingement nozzle jet plate with a differentiation of the nozzle density depending on the local power density enables the cooling of large interposer packages with more than 2kW power dissipation.
311 Evaluation of "Nakiwakare" and peeling property of pressure sensitive adhesive with multi-axies driven test machine (2010)

Recently, PSA(Pressure Sensitive Adhesive) is applied in various industrial conducts products. "Nakiwakare" is knoi as the serious problem that a peeling interface of PSA moves to the opposite one. We conducted the peeling tests in various conditions with the multi axes driven test machine to fmd out the peeling conditions in which Nakiwakare occurred. Additionally, we evaluated the interfacial strength of PSA through the peel tests. We found that there were 2 patterns of Nakiwakare-one in the case of the high-speed and high-angle, and the other in the very low-speed peeling.
Cover Feature: Iron Oxide Nanoparticles Functionalized with Fucoidan: a Potential Theranostic Nanotool for Hepatocellular Carcinoma (ChemBioChem 16/2022) (2022)

Iron oxide nanoparticles (NPs) were functionalized with fucoidan, a natural sulfated polysaccharide. NP cellular uptake was quantified by magnetic measurement at various extracellular iron concentrations. Cell invasion and migration were reduced with NPs. Concomitantly, a high decrease of reactive oxygen species production related with a decrease of the matrix metalloproteinase-9 activity and an increase of its expression was observed. Proteomic analysis showed that some fucoidan regulated proteins appeared related to protein synthesis, N-glycan processing, and cellular stress. These results pave the way for USPIO-fucoidan-NPs as potential theranostic nanotools for hepatocellular carcinoma treatment. More information can be found in the Research Article by F. Geinguenaud et al.
Pilot study of gadoxetate disodium-enhanced mri for localized and metastatic prostate cancers (2021)

OATP1B3 is expressed de novo in primary prostate cancer tissue and to a greater degree in prostate cancer metastases. Gadoxetate disodium is a substrate of OATP1B3, and its uptake has been shown to correlate with OATP1B3 expression in other cancers. We aimed to evaluate use of gadoxetate disodium to image prostate cancer and to track its utility as a biomarker. A single center open-label non-randomized pilot study recruited men with (1) localized, and (2) metastatic castration resistant prostate cancer (mCRPC). Gadoxetate disodium-enhanced MRI was performed at four timepoints post-injection. The Wilcoxon signed rank test was used to compare MRI contrast enhancement ratio (CER) pre-injection and post-injection. OATP1B3 expression was evaluated via immunohistochemistry (IHC) and a pharmacogenomic analysis of OATP1B3, NCTP and OATP1B1 was conducted. The mCRPC subgroup (n = 9) demonstrated significant enhancement compared to pre-contrast images at 20-, 40- and 60-min timepoints (p < 0.0078). The localized cancer subgroup (n = 11) demonstrated earlier enhancement compared to the mCRPC group, but no retention over time (p > 0.05). OATP1B3 expression on IHC trended higher contrast enhancement between 20-40 min (p ≤ 0.064) and was associated with contrast enhancement at 60 min (p = 0.0422). OATP1B1 haplotype, with N130D and V174A substitutions, impacted enhancement at 40-60 min (p ≤ 0.038). mCRPC lesions demonstrate enhancement after injection of gadoxetate disodium on MRI and retention over 60 min. As inter-individual variability in OATP1B3 expression and function has both predictive and prognostic significance, gadoxetate disodium has potential as a biomarker in prostate cancer.
Electrical and Optical Reliability Analysis of GeSi Electro-Absorption Modulators (2020)

Reliability analysis on Electro-Absorption Modulators reveals two degradation parts, trap generation and filling of pre-existing defects on Ge/Si and Ge/Ox interface. After stress, electro-optical extracted parameters indicate no impact of temperature, bias or stress time.
ChemInform Abstract: SYNTHESES OF ANALGESICS PART 37, AN ALTERNATIVE SYNTHESIS OF 1,2,3,4,5,6‐HEXAHYDRO‐8‐HYDROXY‐2,6‐METHANO‐6,11‐DIMETHYL‐3‐PHENETHYL‐3‐BENZAZOCINE (STUDIES ON THE SYNTHESES OF HETEROCYCLIC COMPOUNDS) PART 521 (1973)

Abstract 3‐Methyl‐3‐pentenyl‐amin (Ia) liefert über das Imin (II) die N‐Phenäthylverbin dung (Ib).
Factors Controlling Successful Formation of Mixed-Matrix Gas Separation Materials (2000)

Prior work has suggested simple guidelines for matching transport characteristics of materials to form high-performance mixed-matrix materials for gas separation. Such materials comprise a dispersion of molecular sieving particles in a properly selected matrix polymer phase. Recent work has shown that these simple criteria are necessary but not sufficient to achieve the desired properties. The analysis presented here shows the need to optimize the transport properties of the interfacial region, i.e., the region between the bulk polymer and dispersed sieve phases. Guided by the need to optimize both the transport properties of the interfacial region and the matrix material selection criteria noted above, a new paradigm is recommended for matrix phase selection. The practicality of the paradigm is validated by the formation of mixed-matrix membranes with an appropriate polymer and sieve. These materials lead to the attractive predicted performances at low loading. For success at higher loading a zeolite "priming" protocol based on polymer-solvent sieve interactions is shown to be necessary. This modified protocol leads to success at intermediate and high dispersed-phase loading.
Abstract 2529: A monoclonal anti-Globo H antibody, VK9 can mediate CDC/ADCC and inhibit adhesion of Globo H+ cancer cells to extracellular matrix (2012)

Abstract Globo H is a hexasaccharides expressed on many carcinomas including breast, pancreas, prostate, and stomach, with limited expression on normal tissue. Monoclonal antibodies against glycan, such as CH14.18 GD2-specific antibody, have been proven to be a promising strategy for cancer therapy. Here we evaluated the biological activity and potential application of VK9, a murine IgG3 anti-Globo H antibody. FACS analysis showed that VK9 bound to MCF7 cells in a dose dependent manner at 0.01 - 30 μg/mL. It does not bind to GH (-) cell lines, including AU565 and MDA-MB-231. The specificity of VK9 as determined by glycan array of 87 printed carbohydrates revealed binding of VK9 to three glycans (Globo H, BB4, and BB3) only, without reactivity to Gb5 or sialyl-Gb5. Investigation of the biological activity of VK9 showed no obvious effects on the proliferation of MCF7 cells. However, VK9 inhibited adhesion of MCF7 cell on fibronectin (83.5 ± 1.3%, p = 0.001) or laminin (70.5 ± 2.8%, p = 0.001), but not BSA (85.6 ± 0.2%, p = 0.08) or collagen IV (105.1 ± 2%, p = 0.37), when compared to IgG3 isotype control. Moreover, VK9 was able to mediate CDC against MCF7 cells. It could also induce ADCC of human IL-2 activated peripheral blood mononuclear cells at an E/T of 6.25-100. Furthermore, we cloned the Fab region of VK9 to generate a mouse-human chimeric anti-Globo H antibody, cVK9. The binding affinity of cVK9 was similar to VK9 at concentration range of 6.25 - 50 ug/mL by ELISA analysis. In conclusion, VK9 could not only mediate ADCC and CDC but also inhibit adhesion of MCF7 cell on fibronectin and laminin. Thus, VK9 have the potential as therapeutic antibody for Globo H expressing carcinoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2529. doi:1538-7445.AM2012-2529
Equilibrium limits of coherency in strained nanowire heterostructures (2005)

Due to their unique boundary conditions, nanowire heterostructures may exhibit defect-free interfaces even for systems with large lattice mismatch. Heteroepitaxial material integration is limited by lattice mismatches in planar systems, but we use a variational approach to show that nanowire heterostructures are more effective at relieving mismatch strain coherently. This is an equilibrium model based on the Matthews critical thickness in which the lattice mismatch strain is shared by the nanowire overlayer and underlayer, and could as well be partially accomodated by the introduction of a pair of misfit dislocations. The model is highly portable to other nanowire material systems and can be used to estimate critical feature sizes. We find that the critical radius of this system is roughly an order of magnitude larger than the critical thickness of the corresponding thin film/substrate material system. Finite element analysis is used to assess some aspects of the model; in particular, to show that the variational approach describes well the decay of the strain energy density away from the interface.
Discussion at Cleveland: Papers on paper-machine drive (1926)

T. D. Montgomery: Mr. Staege says that a speed adjustment of from 0.1 to one per cent is required. Does this mean that some classes of paper require 0.1 per cent while others require one per cent, or that regulation anywhere between 0.1 per cent and one per cent meets all conditions of paper making?
Derivation and Expansion of PAX7-Positive Muscle Progenitors from Human and Mouse Embryonic Stem Cells (2014)

Cell therapies treating pathological muscle atrophy or damage requires an adequate quantity of muscle progenitor cells (MPCs) not currently attainable from adult donors. Here, we generate cultures of approximately 90% skeletal myogenic cells by treating human embryonic stem cells (ESCs) with the GSK3 inhibitor CHIR99021 followed by FGF2 and N2 supplements. Gene expression analysis identified progressive expression of mesoderm, somite, dermomyotome, and myotome markers, following patterns of embryonic myogenesis. CHIR99021 enhanced transcript levels of the pan-mesoderm gene T and paraxial-mesoderm genes MSGN1 and TBX6; immunofluorescence confirmed that 91% ± 6% of cells expressed T immediately following treatment. By 7 weeks, 47% ± 3% of cells were MYH(+ve) myocytes/myotubes surrounded by a 43% ± 4% population of PAX7(+ve) MPCs, indicating 90% of cells had achieved myogenic identity without any cell sorting. Treatment of mouse ESCs with these factors resulted in similar enhancements of myogenesis. These studies establish a foundation for serum-free and chemically defined monolayer skeletal myogenesis of ESCs.
Porous organic ligands (POLs) for synthesizing highly efficient heterogeneous catalysts (2014)

We reported a universal route for synthesizing porous organic ligands (POLs) via solvothermal polymerization. The POLs were obtained quantitatively, showing high surface area, large pore volume, hierarchical porosity, and superior stability. The POL bearing a triphenylphosphine supported rhodium catalyst (Rh/POL-PPh3) exhibits high activity and excellent recyclability in 1-octene hydroformylation.
Effect of atorvastatin on inflammatory markers in hemodialysis patients (2020)

Abstract Background Cardiovascular disease is the commonest cause of death in patients with end-stage renal disease (ESRD) under maintenance hemodialysis. Dyslipidemia, oxidative stress, and low-grade inflammation with increased circulating cytokines are factors that increase the cardiovascular risk in patients with chronic kidney disease, in addition to traditional risk factors, such as obesity, hypertension, and diabetes. We aimed to investigate the possible anti-inflammatory effects of atorvastatin in prevalent hemodialysis patients. Fifty-three stable adult hemodialysis patients were assigned into two groups (a drug group and a control group). Patients in the drug group received 20 mg of atorvastatin daily for 6 months. Serum levels of highly sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were measured in both groups at baseline and at the end of the study period. Results Atorvastatin therapy caused a statistically significant decrease in levels of hs-CRP but no change in levels of IL-6 after 6 months of therapy. Conclusions In addition to its favorable effect on lipid profile parameters, atorvastatin therapy can be considered as an effective and safe modality to overcome the problem of chronic inflammation encountered in end-stage renal disease patients.
Panoptic-DeepLab (2019)

We present Panoptic-DeepLab, a bottom-up and single-shot approach for panoptic segmentation. Our Panoptic-DeepLab is conceptually simple and delivers state-of-the-art results. In particular, we adopt the dual-ASPP and dual-decoder structures specific to semantic, and instance segmentation, respectively. The semantic segmentation branch is the same as the typical design of any semantic segmentation model (e.g., DeepLab), while the instance segmentation branch is class-agnostic, involving a simple instance center regression. Our single Panoptic-DeepLab sets the new state-of-art at all three Cityscapes benchmarks, reaching 84.2% mIoU, 39.0% AP, and 65.5% PQ on test set, and advances results on the other challenging Mapillary Vistas.
An end-to-end tool chain for multi-view modeling and analysis of avionics mission computing software (2004)

We present an end-to-end tool-chain for model-based design and analysis of component-based embedded real-time software, with avionics mission computing as an application domain. The tool-chain covers the entire system development lifecycle including modeling, analysis, code generation, and run-time instrumentation. Emphasis is placed on integration of tools developed by multiple institutions via standardized interface format definitions in XML. By capturing all relevant information explicitly in models at the design level, and performing analysis that provides insight into non-functional aspects of the system, we can raise the level of abstraction for the designer, and facilitate rapid system prototyping.
Nondestructive Testing of High Strength Conductors for High Field Pulsed Magnets (2020)

High field pulsed magnets at the NHMFL use high strength conductor wires up to 90% of their ultimate tensile strength. Therefore it is very important to ensure that the wires are free of flaws. It is known that in the conductors' cold drawing process, internal `chevron' crack could occur due to unsuitable drawing die schedule or inadequate lubrication. These internal cracks occurs infrequently along the wire, so tensile tests of short samples cut from the ends of a long length conductor often miss the problem. In addition, small inclusions on the wire surface can compromise wires fatigue properties. In this paper, we present results of our non-destructive testing (NDT) inspection of Glidcop AL60 wires using eddy current testing (ECT), ultrasonic testing (UT) and x-ray radiography (2D and 3D). Chevron cracks were found in some AL60 conductors by all three NDT techniques. Surface inclusions were found by ECT. We have developed a long length ECT wire inspection capability.
1061: Initial Clinical Evaluation of Radiosurgical Treatment of Renal Tumors (2006)

percutaneous RFA was $4561 and percutaneous CA was $7842. Sensitivity analyses showed that for PCA to match PRFA costs, the cryoprobe would have to cost $1119. Minimization of LOS or OR time alone could not overcome the $2960 difference in probe cost. For LCA and LRFA, sensitivity analysis showed that the cryoprobe would have to cost $151 to make operative costs equal, while total minimization of LOS or OR time could not overcome current probe cost differences. Similar results were obtained when modeling with Valleylab Cool-Tip cluster RFA probe priced at $1000 and the Endocare cryoprobe priced at $3000.
In situ formed tert-butyl hypoiodite as an efficient oxidant for rapid, room temperature, metal-free aromatization of Biginelli 3,4-dihydropyrimidin-2(1H)-ones under basic conditions (2016)

A mild, highly efficient synthetic method was developed for the dehydrogenation of 3,4dihydropyrimidin-2(1H)-ones employing in situ formed tert-butyl hypoiodite under basic conditions.The oxidant was prepared by the reaction of molecular iodine and potassium tertbutoxide.The reaction was carried out in dry tetrahydrofuran at room temperature and high purity products were isolated in high yields after simple work-up.The reaction times (3-10 min.)indicated the new method is superior in comparion to other literature oxidants employed under classical conditions or microwave promoted reactions.Two plausible mechanisms of dehydrogenation were proposed and the active species tert-butyl hypoiodite was characterized by UV/Vis spectroscopy method.
Assignment of the rat genes coding for medium-chain acyl-CoA dehydrogenase, isovaleryl-CoA dehydrogenase, and the β subunit of propionyl-CoA carboxylase to chromosomes 2, 3, and 8, respectively (1989)

From the analysis of mouse x rat cell hybrids which segregate rat chromosomes, the rat genes coding for the enzymes medium-chain acyl-CoA dehydrogenase, isovaleryl-CoA dehydrogenase, and the beta-subunit of propionyl-CoA carboxylase have been assigned to chromosomes 2, 3, and 8, respectively.
NIKA2 mapping and cross-instrument SED extraction of extended sources with Scanamorphos (2020)

The steps taken to tailor to NIKA2 observations the Scanamorphos algorithm (initially developed to subtract low-frequency noise from Herschel on-the-fly observations) are described, focussing on the consequences of the different instrument architecture and observation strategy. The method, making the most extensive use of the redundancy built in the multi-scan coverage with large arrays of a given region of the sky, is applicable to extended sources, while the pipeline is so far optimized for compact sources. An example of application is given. A related tool to build consistent broadband SEDs from 60 microns to 2 mm, combining Herschel and NIKA2 data, has also been developed. Its main task is to process the data least affected by low-frequency noise and coverage limitations (i.e. the Herschel data) through the same transfer function as the NIKA2 data, simulating the same scan geometry and applying the same noise and atmospheric signal as extracted from the 1mm and 2mm data.
Silicon Photonic 16 × 16 Cyclic AWGR for DWDM O-Band Interconnects (2020)

In this article, we present for the first time to our knowledge, a DWDM 16 × 16 silicon photonic cyclic-frequency AWGR device. The AWGR features a channel spacing of 1.06 nm (189 GHz), a free spectral range of 17.80 nm (3.16 THz) and a 3-dB channel bandwidth of 0.65 nm (116 GHz). Its proper cyclic-frequency operation was experimentally verified for all 16 × 16 channels with channel peak insertion loss values in the range of 3.90 dB to 8.37 dB, yielding a channel loss non-uniformity of 4.47 dB. Its compact footprint of 0.27 mm × 0.71 mm and its low crosstalk value of 21.65 dB highlight its potential for employment in future AWGR-based interconnect schemes in O-band.
Occurrence and genesis of Miocene peperites in the Tanzawa area, South Fossa Magna, central Japan (2010)

南部フォッサマグナ東部を構成する丹沢地塊には，古伊豆－小笠原弧所属の海洋性島弧を形成していた中新世の水中溶岩類や水中火山砕屑岩類が広く分布している．この島弧火山活動に伴って形成されたペペライトが随所で認められる．ペペライトの存在は堆積作用と火成活動が同時に起こっていた証拠として極めて重要である．本論文では丹沢地塊の4箇所において，4つの岩相のペペライトを記載し，古火山体中での位置づけと，その形成メカニズムを推定した．ペペライトは火山岩片の形状から流体状のペペライト（fluidal peperite）とブロック状のペペライト（blocky peperite）に分けられる．従来，ペペライトのタイプは未固結堆積物の粒径に左右されるとされてきたが，丹沢地塊においては必ずしも堆積物の粒径に左右されてはいないことが分かった．これらのペペライトは，丹沢地塊がかつて所属した古海洋性島弧の火山体中核部附近において，水中火山活動に伴って形成されたものと考えられる．
Application of an advanced trajectory optimization method to ramjet propelled missiles (1980)

Abstract The mission performance characteristics of ramjet‐propelled missiles are highly dependent upon the trajectory flown. Integration of the trajectory profile with the ramjet propulsion system performance characteristics to achieve optimal missile performance is very complex. Past trajectory optimization methods have been extremely problem dependent and require a high degree of familiarity to achieve success. A general computer code (CTOP) has been applied to ramjet‐powered missiles to compute open‐loop optimal trajectories. CTOP employs Chebyshev polynomial representations of the states and controls. This allows a transformation of the continuous optimal control problem to one of parameter optimization. With this method, the trajectory boundary conditions are always satisfied. State dynamics and path constraints are enforced via penalty functions. The presented results include solutions to minimum fuel‐to‐climb, minimumtime‐to‐climb, and minimum time‐to‐target intercept problems.
Characteristics of GaN-based laser diodes for post-DVD applications (2004)

We investigated characteristics of high performance GaN-based laser diodes grown on LEO-GaN/sapphire and free-standing GaN substrates. The maximum output power was 300 mW under cw operation. The operation current and voltage were 53 mA and 4.67 V, respectively, for 30 mW-output power. Thermal simulation and junction temperature measurement of laser diodes showed that epi-down bonding was essential for the use of sapphire substrate. It was proposed that Mg diffusion into active layers was responsible for the degradation mechanism of GaN-based laser diodes. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)