gebhart/patrepeval huggingface dataset:
MR histological correlation: A method for cutting specimens along the imaging plane in animal or ex vivo experiments (2005)

Abstract Purpose To assess a method aimed at cutting histological specimens along the magnetic resonance (MR) imaging plane. Material and Methods The method is performed in two steps: the imaging plane (defined by three acrylic paint markers) is made horizontal under MR guidance by using a mobile platform that can be rotated in three directions (PlaneFinder device [PFD]); then, the specimen is embedded in wax and cut horizontally. Three‐dimensional images parallel to the markers' plane were obtained on 31 pork muscles containing a central hole with a pyramidal shape, with a technique of reference (RT images) and with PFD (PF images), before and after fixation. The last 17 fixed specimens were cut in the markers' plane (tissue section [TS] images). The central hole area (CHA) in the markers' plane was used to compare RT, PF, and TS images. Using a workstation, PF images were rotated and translated to estimate the shift along each direction that could explain the entire CHA difference between RT, PF, and TS images (maximum error, worst‐case scenario). Results Excellent correlation was found between RT and PF images (r = 0.989, slope = 1.0175), PF and TS images (r = 0.991, slope = 1.0058), and RT images on fresh specimens and TS images (r = 0.979, slope = 1.0732). For each step, the maximum angle error was ≤ 3° in 88–95% of the specimens. Conclusion Our methodology can be used to cut specimens along the imaging plane with high accuracy. J. Magn. Reson. Imaging 2006. © 2005 Wiley‐Liss, Inc.
Ex vivo perfusion-based engraftment of genetically engineered cell sensors into transplantable organs (2019)

Cellular rejection of liver transplant allografts remains a concern despite immunosuppressant use. Existing transplant biomarkers are often not sensitive enough to detect acute or chronic rejection at an early enough stage to allow successful clinical intervention. We herein developed a cell-based sensor that can potentially be used for monitoring local events following liver transplantation. Utilizing a machine perfusion system as a platform to engraft the cells into a donor liver, we effectively established the biocompatibility of the biosensor cells and confirmed efficient delivery of cells distributed throughout the organ. This work proves an innovative concept of integrating synthetic reporter cells ex vivo into organs as a transplant-within-a-transplant during functional organ preservation with a vision to use cell biosensors as a broad way to monitor and treat tissue transplants.
Endocrine effects of combined treatment with an LHRH agonist in association with flutamide in metastatic prostatic carcinoma. (1988)

The plasma levels of pituitary hormones (LH, FSH and prolactin) as well as testosterone were determined in 62 patients treated with combined therapy using the LHRH agonist [D-Trp6, des-Gly-NH2(10)]LHRH ethylamide and the antiandrogen Flutamide. Plasma radioimmunoassayable LH and FSH levels increased to 534% (p less than 0.01) and 150% (p less than 0.01) of control, respectively, during the first 5 days of treatment, while, afterwards, a marked inhibition was observed which remained constant at approximately 30-50% of control values during the whole period of treatment. All patients showed a decrease of plasma testosterone concentration to approximately 10% of control levels. Detailed determinations of plasma testicular and adrenal steroid levels were then performed in 15 patients. Our data indicate that, except for the blockade of testicular 17-hydroxyprogesterone secretion, the combined therapy has no effect on plasma C-21 steroid levels. However, adrenal C-19 steroids, namely dehydroepiandrosterone and its sulfate, androst-5-ene-3 beta, 17 beta-diol and androstenedione were decreased to approximately 50% of control values (p less than or equal to 0.01). The main testicular steroids, testosterone and dihydrotestosterone, which were increased during the first 10 days of combined administration, rapidly decreased and reached approximately 10% of control values at later time intervals. The present study extends our previous observations indicating that the combined antihormonal treatment affects both testicular and adrenal steroidogenesis. Moreover, we have demonstrated that, up to at least 2 years, this treatment, in addition to decreasing the serum levels of testicular androgens, causes an inhibition of the plasma levels of C-19 steroids from adrenal origin.
1080: ACUTELY INJURED LUNGS RECEIVE SIGNIFICANTLY LESS POWER THAN HEALTHY LUNGS WITH EXERCISE (2017)

Kamal, Sarah; Cannizzaro, Sean; Lee, Madeline; Sullivan, Joseph; Wilcox, Kailyn; Satalin, Josh; Aiash, Hani; Andrews, Penny; Gatto, Louis; Nieman, Gary; Habashi, Nader Author Information
Effect of the PEG Component of Certolizumab Pegol on Calcium Flux in Cellular Systems (2010)

Purpose: Certolizumab pegol (CZP), the only Fc-free, PEGylated Fab' anti-TNF, has a very low incidence of injection site pain (ISP) in all clinical studies. This could be due to inhibition of mast cell degranulation by the PEG component of CZP1. Mast cells may be involved in mediating ISP as they are present at high numbers in the skin and can rapidly secrete many inflammatory mediators. Changes in calcium (Ca2+) flux from intracellular stores or by influx from outside of the cell are primary indicators of cell activation, and when mast cells degranulate, this is preceded by Ca2+ flux into the cell. PEG has been shown to bind metal ions (in particular Ca2+)2, and the aim of this study was to determine if PEG could inhibit Ca2+ flux in a cellular system. Methods: Peripheral blood monocytes, positively isolated using MACS beads, were incubated for 30 min with the fluorophore Fluo-4, which changes its fluorescence emission when it chelates Ca2+. Ca2+ flux was measured using flow cytometry by detecting the Fluo-4 emission at 515-535 nm. Ionomycin (a Ca2+ ionophore) was added at 2 μg/mL and the emission measured over a 4-min period relative to background, which was assessed for 1 min prior to ionomycin addition. The effect of a range of concentrations of the 40 kDa PEG component of CZP on Ca2+ flux induced by ionomycin was assessed. In addition, the effect of PEG on ionomycin-induced Ca2+ flux in cultured mast cells was determined by a similar method except that the Ca2+ flux was measured using a fluorimeter. Results: Ionomycin caused a dramatic flux of Ca2+ in the monocytes. PEG mediated a dose-dependent inhibition of Ca2+ flux in these cells over a range of concentrations from 40 mg/mL. This is a physiologic concentration of PEG as the equivalent concentration of PEG that is injected into patients is 88.9 mg/mL. The half maximal inhibitory concentration (IC50) for inhibition of the Ca2+ flux by PEG was around 10 mg/mL. The maximum inhibition observed was 84.2% obtained at 40 mg/mL, with the effect titrating out at around 1 mg/mL. In mast cells the IC50 was around 11 mg/mL. Conclusion: The PEG component of CZP inhibits Ca2+ flux in monocytes and mast cells at a concentration relevant to the site of injection. This could explain the effect of CZP observed on inhibition of mast cells and the low levels of ISP observed with CZP in the clinic. Inhibition of Ca2+ flux would only be expected at the site of injection as systemic concentrations of the drug are below the levels where an effect is seen. This property of PEG merits further investigation as low levels of ISP are important for compliance during treatment. References 1. Lamour S, et al. Ann Rheum Dis 2009;68(suppl 3):188. 2. Buschmann H. Z Phys Chem 1984;139:113. Disclosure: Drs Fossati and Nesbitt are both employees of UCB, the manufacturer of certolizumab pegol.
Application of As-Deposited Poly-Crystalline Silicon Films to Low Temperature CMOS Thin Film Transistors (1995)

As-deposited poly-crystalline silicon (poly-Si) films have been applied to low temperature processed complementary metal oxide semiconductor (CMOS) thin film transistors (TFTs). Continuous two-step deposition of poly-Si films in the infra-low pressure chemical vapor deposition (ILPCVD) reduces the silane partial pressure to 0.10 mTorr to obtain high quality films. The maximum processing temperature of 555° C through the CMOS TFT fabrication is during the poly-Si deposition. Since the as-deposited poly-Si films are good in quality, CMOS static shift registers have been successfully integrated on a glass substrate with the as-deposited poly-Si TFTs.
Sobre Visões para a Pesquisa em Gestão de Processos de Negócio (BPM) no PPGI-UNIRIO (2016)

Este relatorio tecnico reune as reflexoes realizadas pelos pesquisadores de mestrado e doutorado do PPGI-UNIRIO durante a disciplina de Gestao de Processos de Negocio (BPM), no primeiro semestre de 2016, a respeito de oportunidades de pesquisa nesta area. Sao apresentados temas de interesse dos pesquisadores e como podem ser explorados em relacao a area de BPM. As reflexoes se baseiam em definicoes conceituais, levantamento preliminar de literatura e estado da arte e, em alguns casos, do estado da pratica.
Investigation of Arsenic Transient Enhanced Diffusion From Emitter Process at 550 °C Si:As RP-CVD Epitaxy Using Disilane Precursor (2022)

Emitter resistivity should be optimized to increase the electrical performances of bipolar transistors. A non-selective Si:As deposition at temperature higher than 600 °C is currently used to fabricate such emitters: poly Si:As grows on dielectrics whereas monocrystalline Si:As grows on Si. A fully monocrystalline material would be needed to reduce the emitter resistivity, however. Therefore, a new process performed at 550 °C has been developed with Si 2 H 6 as the Si precursor. Emitter mono-crystallinity is achieved by coupling amorphous deposition on dielectrics and solid phase epitaxy regrowth. The crystallinity of the structure has been checked by ACOM-TEM. With the Si 2 H 6 process, an unusual diffusion of As is observed and has been reproduced on blanket wafers. The study on blankets wafer highlights that the diffusion is enhanced during a period: no enhanced diffusion occurs between 10 h and 24 h annealing at 720 °C. For the first time, transient enhanced diffusion of As is observed after low temperature epitaxy.
Nitrogen-vacancy center creation with helium-ion microscope (2013)

We investigate a method to create nitrogen-vacancy (NV) centers in diamond using a focused-heliu m-ion-microscopy. Near-surface NV centers can be created with spatial resolution below 0.6μm. NV center spectral line widths at various optical and microwave frequencies were also studied.
Coherent neutron scattering on the 'glassy crystal' of cyanoadamantane (1985)

Reports experimental measurements by coherent neutron scattering on the glassy phase of cyanoadamantane (T=107K). Acoustic dispersion curves and a well defined libration have been measured along the three symmetry directions of the cubic system. Dispersion curves calculated with a phenomenological model taking into account only the average molecules in their site allow good agreement to be obtained with the experimental ones. By elastic scattering, narrow scattering peaks appear near the X points, of the Brillouin zone. These peaks can be explained by the existence of ordered domains with an antiferroelectric arrangement of the molecular dipoles. The correlation length of these domains is of the order of one cell. As for the plastic phase, there is a damped oscillator on the inelastic scans for the glassy state of cyanoadamantane.
Computer vision based inverted pendulum (2002)

In this paper we present a new approach for the classical problem of controlling an inverted pendulum. The approach presented in this paper offers a new perspective to the problem by using a vision system as a visual encoder combined with a specific adaptive control technique simulated and controlled wing a graphical programming package.
Enhanced Kerr effect experienced by ASE light (2001)

A surprisingly high fiber optic Kerr coefficient for Amplified Spontaneous Emission has been measured through self-phase modulation. This enhancement originates from the dependence of two-photon absorption rate on the second-order degree of coherence of light.
Reliability of Nanoelectronic VLSI (2012)

This chapter contains sections titled: Introduction Increased Defect Density and Reliability Reliability Evaluation Historically Important CAD Tools Recent Progress Monte Carlo Reliability Evaluation Tool Fault-Tolerant Computing Conclusions References
Adaptive synchronization of chaotic generators based on tunnel diodes (2002)

Two synchronization algorithms for a pair of semiconductor chaotic generators (transmitter and receiver) are proposed. It is shown, that both of them are efficient under uncertainty of parameters of the transmitter. Computer simulation results are presented confirming the theoretical analysis.
Chemical and morphological characterization of Pd aggregates grown by plasma sputter deposition (1997)

In this work, the synthesis of supported Pd aggregates by plasma sputter deposition is studied. A helicoidal metal wire is negatively biased with respect to the plasma potential, which results in sputtering of the metal by the argon ions present in the plasma. The wire bias voltage is one of the most important experimental parameters because it determines the ion flux bombarding the metal surface as well as the energy of these ions. Thus, it plays a major role in the sputtering process. In order to study this aspect, deposits have been synthesized at mbar argon pressure and 2 min deposition time, at various wire bias voltages from -100 to 0 V. The amount of Pd deposited is measured by x-ray photoelectron spectroscopy (XPS) and Rutherford backscattering spectroscopy (RBS) analyses and is found to increase linearly with the wire bias voltage (in absolute value) from 0.2 to 1.4 equivalent monolayers. In this study, it appears that XPS analysis is not suitable for quantification in the particular case of small dispersed aggregates, certainly because of a geometrical effect (apparent roughness) in recorded XPS line intensities. Nevertheless, from the XPS Pd peak shift with decreasing coverages, morphological information can be obtained. In this manner, the presence of small aggregates on the substrate surface has been detected. The morphology is more precisely studied by grazing incidence small angle x-ray scattering (GISAXS) and transmission electron microscopy (TEM) analyses. In the present metal coverage range, the deposits are composed of small ( nm) spaced-out spherical aggregates, well dispersed on the surface.
Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice (2017)

rmTBI produces acute cognitive and anxiety-like disturbances associated with inflammatory changes in brain regions involved in spatial memory and anxiety.
Beyond Acid Strength in Zeolites: Soft Framework Counteranions for Stabilization of Carbocations on Zeolites and Its Implication in Organic Synthesis (2015)

The generation of a carbocation with an acid depends not only on the acid strength but also on the ability of the counteranion to stabilize the positive charge left behind. Here we report that despite their relatively weak acidity, zeolites are able to generate and stabilize medium-size (molecular weight ≈300 Da) delocalized carbocations on their surface under mild reaction conditions, as it can be done by strong Brønsted or Lewis acids in solution. The zeolite thus acts as a soft macroanion, prolonging the lifetime of the carbocation sufficiently to perform multifunctionalization reactions with amides, thioamides, and phenols, with high yield and selectivity. Biological studies show that some of the products obtained here present significant inhibition activity against colon cancer cells, illustrating the new possibilities of zeolites to prepare complex organic molecules.
Radiation damage studies on a 5T sCMOS image sensor with integrated readout electronics (2010)

In this paper we present radiation studies performed on a low-noise, high-speed, largearea CMOS image sensor (CIS) based on the 0.18 &mu;m CMOS process. The sensor has 2560(H) x 2160(V) pixels with a readout speed of 100 frames/sec and a readout noise of less than 2 e- rms. The sensor features 5T pinned photodiode pixels on a 6.5 &mu;m pitch. In order to measure the impact of radiation exposure on the sensor performance, the device was subjected to x-ray exposure of 50 kRads of incident radiation using a broad band 50 KVP x-ray source to assess Total Ionizing Dose (TID) sensitivity. The active area and the digital control block and amplification circuitry were separately irradiated to evaluate the damage to each. Dark data was captured as a function of radiation dose in order to measure dark current and offset changes in the signal.
Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation (2007)

Mycobacterium tuberculosis evades the innate antimicrobial defenses of macrophages by inhibiting the maturation of its phagosome to a bactericidal phagolysosome. Despite intense studies of the mycobacterial phagosome, the mechanism of mycobacterial persistence dependent on prolonged phagosomal retention of the coat protein coronin-1 is still unclear. The present study demonstrated that several mycobacterial proteins traffic intracellularly in M. bovis BCG-infected cells and that one of them, with an apparent subunit size of M(r) 50,000, actively retains coronin-1 on the phagosomal membrane. This protein was initially termed coronin-interacting protein (CIP)50 and was shown to be also expressed by M. tuberculosis but not by the non-pathogenic species M. smegmatis. Cell-free system experiments using a GST-coronin-1 construct showed that binding of CIP50 to coronin-1 required cholesterol. Thereafter, mass spectrometry sequencing identified mycobacterial lipoamide dehydrogenase C (LpdC) as a coronin-1 binding protein. M. smegmatis over-expressing Mtb LpdC protein acquired the capacity to maintain coronin-1 on the phagosomal membrane and this prolonged its survival within the macrophage. Importantly, IFNgamma-induced phagolysosome fusion in cells infected with BCG resulted in the dissociation of the LpdC-coronin-1 complex by a mechanism dependent, at least in part, on IFNgamma-induced LRG-47 expression. These findings provide further support for the relevance of the LpdC-coronin-1 interaction in phagosome maturation arrest.
Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study (2020)

Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment.Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect. What is Known: • LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation. What is New: • Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.
Crystal drift compensation in a mobile phone (2006)

We propose a novel method of performing frequency synchronization of local oscillator in a mobile phone to a stable reference of the base station. A free-running crystal oscillator (XO) is used instead of an expensive voltage-controlled or digitally-controlled XO. The frequency drift of the crystal is adjusted in the digital domain of the frequency synthesizer&apos;s frequency command word. The proposed techniques have been successfully implemented in a single-chip GSM transceiver realized in 90 nm CMOS.
Macrokinetic effects in perhydro-N-ethylcarbazole dehydrogenation and H2productivity optimization by using egg-shell catalysts (2015)

This contribution deals with pore diffusion influences on the dehydrogenation kinetics of perhydro-<italic>N</italic>-ethylcarbazole (H12-NEC).
Interface States Characterization of UTB SOI MOSFETs From the Subthreshold Current (2020)

Quantification of interface traps for double-gate fully depleted silicon-on-insulator transistors is needed for accurate device modeling and technology development. The trap density can be estimated as a function of the activation energy from the subthreshold current using the methodology developed in this work. It combines the earlier proposed <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${g}_{\text {m}}/ {I}_{\text {D}}$ </tex-math></inline-formula> method with a revised form of the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${k}$ </tex-math></inline-formula> -sweep method. The method is verified using TCAD simulated data and applied on engineering samples produced in 22FDX (R) technology, yielding a typical trap density of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${2}\,\,\cdot \,\,{10}^{{11}}\,\,\text {cm}^{-{2}}\text {eV}^{-{1}}$ </tex-math></inline-formula> . Association of the traps to the front or back interface is nontrivial; a trap allocation error of at least 20% is reported.
Folding and aggregation of beta-lactamase in the periplasmic space of Escherichia coli. (1990)

High level expression of TEM beta-lactamase results in the accumulation of precursor and mature protein in the insoluble fraction of Escherichia coli. The mature polypeptide is sequestered in protein aggregates (inclusion bodies) located within the periplasmic space whereas the insoluble precursor is present in the cytoplasm. With the native beta-lactamase, aggregation is observed when the rate of expression exceeds 2.5% of the total protein synthesis rate. Substitution of the native signal sequence with the outer membrane protein A (OmpA) leader peptide results in extensive aggregation of only the mature protein. Furthermore, for OmpA-beta-lactamase, the accumulation of mature insoluble protein is independent of the rate of protein synthesis. These observations cannot be accounted by the kinetics of export of the OmpA-beta-lactamase and the native precursor, therefore suggesting that the signal sequence affects the conformation of the newly secreted mature polypeptide and in turn, the folding pathway. Previously, we have shown that the aggregation of the mature protein secreted using its own signal sequence can be inhibited by growing the cells in the presence of non-metabolizable sugars such as sucrose (Bowden, G., and Georgiou, G. (1988) Biotechnol. Prog. 4, 97-101). We show here that this phenomenon is not related to osmotic effects, changes in beta-lactamase translation or precursor processing. It follows that the addition of sugars exerts a direct effect on the in vivo pathway of aggregation and folding, in analogy with the well characterized effect of sugars in vitro.
Severe alterations of red blood cells from the vessels of colorectal tumors. (1985)

The RBCs from vessels supplying the tumors of 14 patients with colorectal carcinoma were examined with the scanning electron microscope. In all of them a great variety of alterations in the shape and the cell membrane were found. Erythrocytes from the vessels of healthy colonic tissue of the patients were found to have a normal appearance. Since fibrin thrombi were present in a few vessels of only six patients, the possibility that the alterations were due to mechanical trauma was not likely. This observation may serve as an additional explanation for the anemia observed in patients with colorectal carcinoma.