gebhart/patrepeval huggingface dataset:
Selective Deoxygenation and O-Methylation of Benanomicin A: Synthesis of 9-Deoxy-, 9-0-Methyl- and 14-0-Methylbenanomicin A. (1997)

The selective modifications of phenolic hydroxy groups in the chromophore of benanomicin A are described. Hydride reduction of 9-O-tosylate with sodium borohydride/nickel chloride led to 9-deoxybenanomicin A. Methylation of 1-O-diphenylmethylbenanomicin A diphenylmethyl ester with sodium hydride/iodomethane gave 9-O-methyl derivative and with Hünig's base/diazotrimethylsilylmethane afforded the 14-O-methyl derivative. These compounds showed the diminished activity against fungi.
Probing molecular dynamics at the nanoscale via an individual paramagnetic centre (2015)

We demonstrate a protocol using individual nitrogen-vacancy centres in diamond to observe the time evolution of proton spins from organic molecules located a few nanometres from the diamond surface. The protocol records temporal correlations among the interacting protons, and thus is sensitive to the local dynamics via its impact on the nuclear spin relaxation and interaction with the nitrogen vacancy. We gather information on the nanoscale rotational and translational diffusion dynamics by analysing the time dependence of the nuclear magnetic resonance signal. Applying this technique to liquid and solid samples, we find evidence that liquid samples form a semi-solid layer of 1.5-nm thickness on the surface of diamond, where translational diffusion is suppressed while rotational diffusion remains present. Extensions of the present technique could be exploited to highlight the chemical composition of molecules tethered to the diamond surface or to investigate thermally or chemically activated dynamical processes such as molecular folding.
Predict Electric Power Demand with Extended Goal Graph and Heterogeneous Mixture Modeling (2019)

In this study, methods for predicting energy demand on hourly consumption data are established for realizing an energy management system for buildings. The methods consist of an energy prediction algorithm that automatically separates the datasets to partitions (gate) and creates a linear regression model (local expert) for each partition on the heterogeneous mixture modeling, and an extended goal graph that extracts candidates of variables both for data partitioning and for linear regression for the energy prediction algorithm. These methods were implemented as tools and applied to create the energy prediction model on two years' hourly consumption data for a building. We validated the methods by comparing accuracies with those of different machine learning algorithms applied to the same datasets.
Preservation of facial nerve function after resection of vestibular schwannoma (2010)

Factors that appear to be associated with facial nerve preservation after microsurgical resection of a vestibular schwannoma include tumour size <20 mm, use of the middle fossa approach and use of neuromonitoring during surgery. These data provide a summary assessment of the published literature regarding facial nerve preservation after microsurgical resection of vestibular schwannoma.
Analysis and Design Specifications for Full-Duplex Radio Transceivers\n under RF Oscillator Phase-Noise with Arbitrary Spectral Shape (2014)

In this paper, the effects of oscillator phase-noise with arbitrary spectral\ncharacteristics on self-interference cancellation capability of a full-duplex\nradio transceiver are addressed, and design considerations are given for\noscillator designers for optimized PLL design for full-duplex radio\napplication. The paper first gives a full-duplex transceiver model that\ninherently mitigates most of the phase-noise effect from the self-interference\nsignal. The remaining effect of the phase noise is then analysed. Closed-form\nsolutions for the self-interference power are then derived. In the simulations\npart, a practical phase-locked loop type oscillator is used, which is based on\nthe arbitrary mask phase-noise model. Analytical derivations are verified with\nthe simulations, and the self-interference cancellation performance is\nthoroughly studied with various parameters. Design considerations are finally\ngiven for oscillator design for full-duplex radio transceivers, with the help\nof tangible parameters of the phase-locked loop type oscillators.\n
The Cognitive Relevance of a Formal Pre-incision Time-out in Surgery (2021)

Surgical time-outs are designed to promote situation awareness, teamwork, and error prevention. The pre-incision time-out in particular aims to facilitate shared mental models prior to incision. Objective, unbiased measures to confirm its effectiveness are lacking. We hypothesized that providers' mental workload would reveal team psychophysiological mirroring during a formal, well-executed pre-incision time-out. Heart rate variability was collected during cardiac surgery cases from the surgeon, anesthesiologist, and perfusionist. Data were analyzed for six cases from patient arrival until sternal closure. Annotation of surgical phases was completed according to previously developed standardized process models of aortic valve replacement and coronary artery bypass graft procedures, producing thirteen total surgical phases. Statistical analysis revealed significant main effects. Tukey HSD post hoc tests revealed significant differences across provider roles within various phases, including Anesthesia Induction, Heparinization, Initiation of Bypass, Aortic Clamp and Cardioplegia, Anastomoses or Aortotomy, Separation from Bypass, and Sternal Closure. Despite these observed differences between providers over various surgical phases, the Pre-incision Time-out phase revealed almost negligible differences across roles. This preliminary work supports the utility of the pre-incision safety checklist to focus the attention of surgical team members and promote shared team mental models, measured via psychophysiological mirroring, using an objective mental workload measure. Future studies should investigate the relationship between psychophysiological mirroring among surgical team members and the effectiveness of the pre-incision time-out checklist.
Fertility Restoration by Seminal Tract Washout in Ejaculatory Duct Obstruction (1995)

A complex case of secondary sterility due to excretory azoospermia-dry ejaculation is reported. Transrectal ultrasonography and vaso-vesiculography revealed post-inflammatory total obstruction of the right ejaculatory duct. Excluding small radiolucent concrements in the seminal vesicle, no anatomical anomalies were identified on the left side. By performing antegrade seminal tract washout with saline solution it was possible to clear both seminal ducts and restore fertility in our patient. In select cases seminal tract washout may be a valid alternative to the conventional transurethral surgical approach for acquired obstruction of the ejaculatory ducts.
Cardiac Neuroanatomy for the Cardiac Electrophysiologist (2020)

The cardiac neuraxis is integral to cardiac physiology, and its dysregulation is implicated in cardiovascular disease. Neuromodulatory therapies are being developed that target the cardiac autonomic nervous system (ANS) to treat cardiac pathophysiology. An appreciation of the cardiac neuroanatomy is a prerequisite for development of such targeted therapies. Here, we provide a review of the current understanding of the cardiac ANS. The parasympathetic and sympathetic nervous system are composed of higher order cortical centers, brainstem, spinal cord, intrathoracic extracardiac ganglia and intrinsic cardiac ganglia. A series of interacting feedback loops mediates reflex pathways to exert control over the cardiac conduction system and contractile tissue. Further exploration of this complex regulatory system promises to yield neuroscience-based therapeutics for cardiac disease.
CREATION OF TENECTEPLASE-PRODUCING CHO CELL LINE USING SITE-SPECIFIC INTEGRASE FROM THE PHAGE φC31 (2010)

Objective: The aim of this study was to produce a stable CHO cell line expressing tenecteplase. Materials and Methods: In the first step, the tenecteplase coding sequence was cloned in a pDB2 vector containing attB recognition sites for the phage φC31 integrase. Then, using lipofection, the CHO cells were co-transfected with constructed recombinant plasmid encoding tenecteplase and attB recognition sites and the integrase coding sequence containing pCMV-Int plasmid. As the recombinant plasmid contained the neomycin resistance gene (neo), stable cells were then selected using G418 as an antibiotic. Stable transformed cells were assessed using genomic PCR and RT-PCR. Finally, the functionality of tenecteplase was evaluated on the cell culture media. Results: our results indicated that tenecteplase coding sequence was inserted into the CHO cell genome and was successfully expressed. Moreover, tenecteplase activity assessment indicated the presence of our functional tenecteplase in the cell culture medium. Conclusion: Considering the data obtained from this study, φC31 integrase can be used for the production of a stable cell line and it be used to introduce ectopic genes into mammalian cells.
Proteomic Analysis of Cerebrospinal Fluid in a Fulminant Case of Multiple Sclerosis (2012)

Multiple Sclerosis (MS) is a chronic disease, but in rare fulminant cases rapid progression may lead to death shortly after diagnosis. Currently there is no diagnostic test to predict disease course. The aim of this study was to identify potential biomarkers/proteins related to rapid progression. We present the case history of a 15-year-old male MS patient. Cerebrospinal fluid (CSF) was taken at diagnosis and at the time of rapid progression leading to the patient's death. Using isobaric tag labeling and nanoflow liquid chromatography in conjunction with matrix assisted laser desorption/ionization time of flight tandem mass spectrometry we quantitatively analyzed the protein content of two CSF samples from the patient with fulminant MS as well as one relapsing-remitting (RR) MS patient and one control headache patient, whose CSF analysis was normal. Seventy-eight proteins were identified and seven proteins were found to be more abundant in both fulminant MS samples but not in the RR MS sample compared to the control. These proteins are involved in the immune response, blood coagulation, cell proliferation and cell adhesion. In conclusion, in this pilot study we were able to show differences in the CSF proteome of a rapidly progressing MS patient compared to a more typical clinical form of MS and a control subject.
Search for top-squark pair production in the single-lepton final state in pp collisions at √s = 8 TeV (2013)

This paper presents a search for the pair production of top squarks in events with a single isolated electron or muon, jets, large missing transverse momentum, and large transverse mass. The data sample corresponds to an integrated luminosity of 19.5 fb−1 of pp collisions collected in 2012 by the CMS experiment at the LHC at a center-of-mass energy of √ s = 8 TeV. No significant excess in data is observed above the expectation from standard model processes. The results are interpreted in the context of supersymmetric models with pair production of top squarks that decay either to a top quark and a neutralino or to a bottom quark and a chargino. For small mass values of the lightest supersymmetric particle, top-squark mass values up to around 650 GeV are excluded.
VLF component attenuation in chagasic myocardiopathy measured in Holter recordings (2002)

Ten Holter records were analyzed, corresponding to four chagasic patients who suffered sudden death during Holter recording, three chagasic patients that survived and three normal subjects. HRV signals were obtained from Holter tapes. Power spectral analysis was performed on each series by AR modeling. Compressed spectral arrays (CSA) were plotted for each series, where a tendency was observed to maintain frequency peak positions along time in sudden death series, as opposite to control series, where the frequency position of the peaks had many oscillations around the center frequency. A strong reduction was found in the VLF component in the death series as compared to the others.
<title>Efficient VLSI algorithm and an implementation architecture for gray-scale morphology</title> (1990)

This paper presents an efficient VLSI architecture for the real-time implementation of grayscale morphological operations. The proposed architecture employs a bit-serial approach which allows grayscale morphological operations to be decomposed into bit-level binary operations by a bit-modification algorithm, and thus requires only p binary operation units for the p-bit grayscale signal. In this realization, grayscale opening and closing are accomplished by local rather than cascade operations, providing greatly increased data throughput. It is shown that this realization is simple and modular in structure and is suitable for VLSI implementation.
Observer-based adaptive control of a variable reluctance motor: experimental results (2002)

Presents experimental results for two adaptive nonlinear controllers applied to a variable reluctance motor (VRM). The first controller requires both rotor position and velocity (full state) feedback, while the latter is a backstepping-type output feedback controller, requiring only rotor position measurement. Velocity for the full-state controller is estimated using a high-gain "differentiating filter". The experimental comparison shows that the observer-based controller provides a better transient response and a smaller steady-state tracking error when gains for both controllers are comparable.
ChemInform Abstract: TUNGSTEN(IV) ALKYNE COMPLEXES (1984)

Abstract WCl 4 reagiert in Diethylether bei Raumtemp. mit Alkinen zu den Komplexen (I).
Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies (2016)

Potent CD19-directed immunotherapies, such as chimeric antigen receptor T cells (CART) and blinatumomab, have drastically changed the outcome of patients with relapsed/refractory B cell acute lymphoblastic leukemia (B-ALL). However, CD19-negative relapses have emerged as a major problem that is observed in approximately 30% of treated patients. Developing approaches to preventing and treating antigen-loss escapes would therefore represent a vertical advance in the field. Here, we found that in primary patient samples, the IL-3 receptor α chain CD123 was highly expressed on leukemia-initiating cells and CD19-negative blasts in bulk B-ALL at baseline and at relapse after CART19 administration. Using intravital imaging in an antigen-loss CD19-negative relapse xenograft model, we determined that CART123, but not CART19, recognized leukemic blasts, established protracted synapses, and eradicated CD19-negative leukemia, leading to prolonged survival. Furthermore, combining CART19 and CART123 prevented antigen-loss relapses in xenograft models. Finally, we devised a dual CAR-expressing construct that combined CD19- and CD123-mediated T cell activation and demonstrated that it provides superior in vivo activity against B-ALL compared with single-expressing CART or pooled combination CART. In conclusion, these findings indicate that targeting CD19 and CD123 on leukemic blasts represents an effective strategy for treating and preventing antigen-loss relapses occurring after CD19-directed therapies.
ChemInform Abstract: In vitro and in vivo Biological Evaluation of New 4,5‐Disubstituted 1,2,3‐Triazoles as cis‐Constrained Analogues of Combretastatin A4. (2012)

Abstract Triazoles (IV) and (VI) are obtained according to procedures already described or reported.
The Reactivity of Charged Electrode Materials with Sodium Bis(trifluoromethanesulfonyl)imide (NaTFSI) Based-Electrolyte at Elevated Temperatures (2013)

Sodium bis(trifluoromethanesulfonyl)imide (NaTFSI) was studied as a salt for possible use in sodium-ion batteries. NaTFSI was found to be more thermally stable than NaPF6 in thermogravimetric analysis (TGA) tests. The electrochemical performance of NaTFSI in propylene carbonate (PC) electrolyte was tested using NaCrO2/Na half cells and hard carbon/Na half cells near room temperature. All cells showed equivalent capacity and cycling performance compared to cells using NaClO4/PC electrolyte. The reactivity of deintercalated NaCrO2 (∼ Na0.5CrO2) and sodium-inserted hard carbon (called Na/HC below) in NaTFSI/PC electrolyte was studied using Accelerating Rate Calorimetry (ARC). Na0.5CrO2 shows equivalent reactivity in NaTFSI/PC electrolyte compared to that in NaPF6/EC:DEC electrolyte at elevated temperature. Na/HC shows a lower reactivity in NaTSFI/PC electrolyte compared to NaPF6/EC:DEC and NaClO4/PC electrolytes.
Hyperextension injuries of the thoracic spine in diffuse idiopathic skeletal hyperostosis. Report of four cases. (1994)

Four patients who had multisegmental ankylosis of the thoracic and lumbar spine due to diffuse idiopathic skeletal hyperostosis sustained a hyperextension fracture-dislocation. The patients had a mean age of sixty-four years (range, fifty-eight to sixty-nine years); all four patients were men. All injuries occurred between the seventh and eleventh thoracic vertebrae. All patients had intact neurological function at the time of admission to the hospital. Three patients were managed with posterior spinal arthrodesis with Cotrel-Dubousset segmental instrumentation; one patient was managed non-operatively with a molded thoracolumbosacral orthosis. At a minimum duration of follow-up of twenty-two months (mean, twenty-seven months), the three patients who had been managed operatively had healing of the fracture with anatomical alignment of the spine and without postoperative complications. The one patient who had been managed non-operatively with a brace had severe neurological deterioration and non-anatomical alignment of the spine.
Dip-Pen Nanolithography of High-Melting-Temperature Molecules (2006)

Direct nanopatterning of a number of high-melting-temperature molecules has been systematically investigated by dip-pen nanolithography (DPN). By tuning DPN experimental conditions, all of the high-melting-temperature molecules transported smoothly from the atomic force microscope (AFM) tip to the surface at room temperature without tip preheating. Water meniscus formation between the tip and substrate is found to play a critical role in patterning high-melting-temperature molecules. These results show that heating an AFM probe to a temperature above the ink's melting temperature is not a prerequisite for ink delivery, which extends the current "ink-substrate" combinations available to DPN users.
Assessments of image-based and scatterometry-based overlay targets (2016)

Having a well designed overlay metrology target is one of the ways to improve on-product overlay performance. The traditional screening method in which multiple targets types are added to successive reticle tape outs and then evaluated by trial-and-error may not suffice for the 7nm node and beyond. For instance, although segmentation of image-based overlay target has been reported by many as a means for improving overlay measurement, we find that segmentation does not guarantee improvement. In fact it can be undesirable. Fundamental understandings of metrology and wafer process are required to properly design the targets and carefully optimize them for a given process stack involving multilevel measurement. This paper investigates the Blossom, AIM, and scatterometry targets at the FEOL, MOL, and BEOL patterning levels in 7nm node to gain knowledge needed in order to comprehensively map out the overlay target solutions for future nodes.
Lensless Imaging: A computational renaissance (2016)

The basic design of a camera has remained unchanged for centuries. To acquire an image, light from the scene under view is focused onto a photosensitive surface using a lens. Over the years, the photosensitive surface has evolved from a photographic film to an array of digital sensors. However, lenses remain an integral part of modern imaging systems in a broad range of applications.
Ezetimibe in Combination With Statins Ameliorates Endothelial Dysfunction in Coronary Arteries After Stenting (2016)

The CuVIC trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction after Coronary Stenting) has shown that ezetimibe with statins, compared with statin monotherapy, improves functional prognoses, ameliorating endothelial dysfunction in stented coronary arteries, and was associated with larger decreases in oxysterol levels.
Molecular Cloning of ATR5Emoy2 from Hyaloperonospora arabidopsidis, an Avirulence Determinant That Triggers RPP5-Mediated Defense in Arabidopsis (2011)

RPP5 is the seminal example of a cytoplasmic NB-LRR receptor-like protein that confers downy mildew resistance in Arabidopsis thaliana. In this study, we describe the cloning and molecular characterization of the gene encoding ATR5(Emoy2), an avirulence protein from the downy mildew pathogen Hyaloperonospora arabidopsidis isolate Emoy2. ATR5(Emoy2) triggers defense response in host lines expressing the functional RPP5 allele from Landsberg erecta (Ler-0). ATR5(Emoy2) is embedded in a cluster with two additional ATR5-like (ATR5L) genes, most likely resulting from gene duplications. ATR5L proteins do not trigger RPP5-mediated resistance and the copy number of ATR5L genes varies among H. arabidopsidis isolates. ATR5(Emoy2) and ATR5L proteins contain a signal peptide, canonical EER motif, and an RGD motif. However, they lack the canonical translocation motif RXLR, which characterizes most oomycete effectors identified so far. The signal peptide and the N-terminal regions including the EER motif of ATR5(Emoy2) are not required to trigger an RPP5-dependent immune response. Bioinformatics screen of H. arabidopsidis Emoy2 genome revealed the presence of 173 open reading frames that potentially encode for secreted proteins similar to ATR5(Emoy2), in which they share some motifs such as EER but there is no canonical RXLR motif.