gebhart/patrepeval huggingface dataset:
Supplementary Figure 1 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner (2023)

&lt;p&gt;PDF file - 1MB, A, H2087 B, H157 and C, H460 were treated with cisplatin (black circles) or cisplatin in combination with 10 mM JP1201 (open circles). D, H2887 E, H358 and F, H157 were treated with doxorubicin (black circles) or doxorubicin in combination with 10 mM JP1201 (open circles). G, H1395 H, H441 and I, H460 were treated with gemcitabine (black circles) or gemcitabine in combination with 10 mM JP1201 (open circles). J, H1819 K, H2882 and L, H460 were treated with paclitaxel (black circles) or paclitaxel in combination with 10 mM JP1201 (open circles). M, H2073 N, A549 and O, H2087 were treated with vinorelbine (black circles) or vinorelbine in combination with 10 mM JP1201 (open circles). P, H157 Q, A549 and R, H2073 (bottom) were treated with erlotinib (black circles) or erlotinib in combination with 10 mM JP1201 (open circles).&lt;/p&gt;
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling Reactions of 2‐Diazonaphthoquinones with Arylboronic Acids. (2011)

Abstract Unsubstituted diazonaphthoquinone (I) reacts with various boronic acids under the optimized conditions to produce the target compounds in moderate to good yield in dependence of the aryl substituents.
Power Converter Design for an Integrated Modular Motor Drive (2007)

The Integrated Modular Motor Drive (IMMD) concept provides a promising approach to integrating motor drive electronics into the machine housing by modularizing both the machine stator and the power converter. The basic module of the IMMD consists of a stator pole-piece wound with a concentrated coil and fitted with a dedicated power converter unit. This paper addresses several of the challenges associated with the design of an IMMD power converter module. In particular, the issues associated with configuring the dc bus capacitance to meet the demanding size requirements of the power converter are addressed, including the effect of dc bus connections. Experimental results for converter operation are presented, and opportunities to further reduce the capacitor size using active control strategies are discussed.
Array Processing of Passive Sonobuoys for Underwater Target Tracking (2010)

Underwater target tracking in ocean environment has attracted considerable interest in both military and civilian applications. Towards this purpose, sonobuoys are among the capable sonar systems used in underwater environments. Sonobuoys are used to detect and track underwater objects emitting sounds. The main factors influencing the operation of sonobuoys are the interference sources and background noise. This book investigates: (1)The application of high resolution spectral estimation algorithm to improve target detection and enhance the accuracy of bearing estimation; (2) The theoretical requirements for sonobuoys positioning in order to feasibly and coherently process a field of sonobuoys; (3) Coherent processing of uniform and arbitrary arrays of GPS sonobuoys; (4) The integration of frequency domain adaptive beamforming with artificial neural network (ANN) to resolve the ambiguity existing in bearing estimation when processing widely spaced array omni-directional sonobuoys; (5) The development of virtual array search method to enhance the bearing estimation when processing sparse array of directional sonobuoys.
Stopped-flow kinetic analysis of the interaction of anthraquinone anticancer drugs with calf thymus DNA, poly[d(G-C)].cntdot.poly[d(G-C)], and poly[d(A-T)].cntdot.poly[d(A-T)] (1986)

The sodium dodecyl sulfate driven dissociation reactions of daunorubicin (1), mitoxantrone (2), ametantrone (3), and a related anthraquinone without hydroxyl groups on the ring or side chain (4) from calf thymus DNA, poly[d(G-C)]2, and poly[d(A-T)]2 have been investigated by stopped-flow kinetic methods. All four compounds exhibit biphasic dissociation reactions from their DNA complexes. Daunorubicin and mitoxantrone have similar dissociation rate constants that are lower than those for ametantrone and 4. The effect of temperature and ionic strength on both rate constants for each compound is similar. An analysis of the effects of salt on the two rate constants for daunorubicin and mitoxantrone suggests that both of these compounds bind to DNA through a mechanism that involves formation of an initial outside complex followed by intercalation. The daunorubicin dissociation results from both poly[d(G-C)]2 and poly[d(A-T)]2 can be fitted with a single exponential function, and the rate constants are quite close. The ametantrone and 4 polymer dissociation results can also be fitted with single exponential curves, but with these compounds the dissociation rate constants for the poly[d(G-C)]2 complexes are approximately 10 times lower than for the poly[d(A-T)]2 complexes. Mitoxantrone also has a much slower dissociation rate from poly[d(G-C)]2 than from poly[d(A-T)]2, but its dissociation from both polymers exhibits biphasic kinetics. Possible reasons for the biphasic behavior with the polymers, which is unique to mitoxantrone, are selective binding and dissociation from the alternating polymer intercalation sites and/or dual binding modes of the intercalator with both side chains in the same groove or with one side chain in each groove.
Influence of sintered Nd-Fe-B magnet corrosion on permanent magnet synchronous motor performance (2013)

Permanent magnet (PM) synchronous motors have found numerous applications over the last two decades due to their high torque to weight ratio and efficiency. However, one of the main drawbacks of the PM motors is the magnet corrosion. This paper investigates the influence of magnet corrosion on the performance of surface mounted permanent magnet motors. Un-corroded and corroded magnet rotors are used to investigate the motor performance including voltage and torque constants. It has been found out that the corroded rotor does not degrade the motor performance even after the intense corrosion tests if good quality NdFeB magnets are used.
Rapid GC‐FID quantification technique without authentic samples using predicted response factors (2012)

ABSTRACT Because a flame ionization detector (FID) is based on the combustion of analytes, we have previously shown that a good correlation exists between the relative response factors (RRFs) and the combustion enthalpies. The latter can themselves be predicted by ab initio calculation, or directly from the molecular formula. As a consequence, the RRFs can be simulated with good accuracy for all volatile constituents of flavours and fragrances. The technique is exemplified here with several applications in the field of flavours and fragrances. The composition of complex mixtures by full internal standardization is very time consuming. This task can be greatly shortened with satisfactory accuracy if predicted RRFs are used instead of the inaccurate semi‐quantification (all RRFs = 1). Non‐commercially available compounds normally require re‐synthesis to determine their RRFs. This time‐consuming step can be avoided and the compounds well quantified by using predicted RRFs. In addition, with unstable standards, measuring their RRFs or purities is impossible, whereas this issue is overcome with the present technique. We herein report the successful testing of the predicted RRFs in comprehensive GC×GC‐FID. Copyright © 2012 John Wiley &amp; Sons, Ltd.
PEG Spacer Length Substantially Affects Antibody-Based Nanocarrier Targeting of Dendritic Cell Subsets (2022)

Successful cell targeting depends on the controlled positioning of cell-type-specific antibodies on the nanocarrier's (NC) surface. Uncontrolled antibody immobilization results in unintended cell uptake due to Fc-mediated cell interaction. Consequently, precise immobilization of the Fc region towards the nanocarrier surface is needed with the Fab regions staying freely accessible for antigen binding. Moreover, the antibody needs to be a certain distance from the nanocarrier surface, influencing the targeting performance after formation of the biomolecular corona. This can be achieved by using PEG linker molecules. Here we demonstrate cell type-specific targeting for dendritic cells (DC) as cellular key regulators of immune responses. However, to date, dendritic cell targeting experiments using different linker lengths still need to be conducted. Consequently, we focused on the surface modification of nanocarriers with different molecular weight PEG linkers (0.65, 2, and 5 kDa), and their ability to reduce undesired cell uptake, while achieving efficient DC targeting via covalently immobilized antibodies (stealth targeting). Our findings demonstrate that the PEG linker length significantly affects active dendritic cell targeting from cell lines (DC2.4) to primary cells (BMDCs, splenocytic conventional DCs type 1 (cDC1)). While antibody-functionalized nanocarriers with a shorter PEG length (0.65 kDa) showed the best targeting in DC2.4, a longer PEG length (5 kDa) was required to specifically accumulate in BMDCs and splenocytic cDC1. Our study highlights that these crucial aspects must be considered when targeting dendritic cell subsets, which are of great importance in the fields of cancer immunotherapy and vaccine development.
Action video games as exemplary learning tools (2010)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Bacterial Nanocellulose‐Based Flexible Surface Enhanced Raman Scattering Substrate (2016)

Owing to high purity, simple surface chemistry, and 3D nanofibrous structure, biosynthesized bacterial nanocellulose (BNC) is a highly attractive biomaterial for a wide range of applications. Conventional cellulose‐based laboratory filter paper, adsorbed with plasmonic nanostructures can be employed as a flexible surface enhanced Raman scattering (SERS) substrate. In this work, a BNC film‐based SERS substrate fabricated by gravity‐assisted filtration method is reported. The 3D porous structure of BNC facilitates uniform and dense adsorption of plasmonic nanostructures on the surface and in subsurface regions, which results in large SERS enhancement. Furthermore, significantly lower surface roughness of BNC compared to conventional filter paper results in an excellent uniformity of SERS activity across the entire substrate. Harnessing the smooth surface of BNC, it is shown that BNC‐based SERS substrate serves as an ideal platform for collection, detection, and recognition of bacteria. The 3D plasmonic BNC composites demonstrated here are highly attractive for a broad range of applications including sensing, catalysis, and energy harvesting.
Feasibility and physics potential of detecting $^8$B solar neutrinos at JUNO (2020)

The Jiangmen Underground Neutrino Observatory~(JUNO) features a 20~kt multi-purpose underground liquid scintillator sphere as its main detector. Some of JUNO's features make it an excellent experiment for $^8$B solar neutrino measurements, such as its low-energy threshold, its high energy resolution compared to water Cherenkov detectors, and its much large target mass compared to previous liquid scintillator detectors. In this paper we present a comprehensive assessment of JUNO's potential for detecting $^8$B solar neutrinos via the neutrino-electron elastic scattering process. A reduced 2~MeV threshold on the recoil electron energy is found to be achievable assuming the intrinsic radioactive background $^{238}$U and $^{232}$Th in the liquid scintillator can be controlled to 10$^{-17}$~g/g. With ten years of data taking, about 60,000 signal and 30,000 background events are expected. This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter, which will shed new light on the tension between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework. If $Δm^{2}_{21}=4.8\times10^{-5}~(7.5\times10^{-5})$~eV$^{2}$, JUNO can provide evidence of neutrino oscillation in the Earth at the about 3$σ$~(2$σ$) level by measuring the non-zero signal rate variation with respect to the solar zenith angle. Moveover, JUNO can simultaneously measure $Δm^2_{21}$ using $^8$B solar neutrinos to a precision of 20\% or better depending on the central value and to sub-percent precision using reactor antineutrinos. A comparison of these two measurements from the same detector will help elucidate the current tension between the value of $Δm^2_{21}$ reported by solar neutrino experiments and the KamLAND experiment.
Automated Leak Detection of Buried Tanks Using Geophysical Methods at the Hanford Nuclear Site (2011)

At the Hanford Nuclear Site in Washington State, the Department of Energy oversees the containment, treatment, and retrieval of liquid high‐level radioactive waste. Much of the waste is stored in single‐shelled tanks (SSTs) built between 1943 and 1964. Currently, the waste is being retrieved from the SSTs and transferred into newer double‐shelled tanks (DSTs) for temporary storage before final treatment. Monitoring the tanks during the retrieval process is critical to identifying leaks. An electrically‐based geophysics monitoring program for leak detection and monitoring (LDM) has been successfully deployed on several SSTs at the Hanford site since 2004. The monitoring program takes advantage of changes in contact resistance that will occur when conductive tank liquid leaks into the soil. During monitoring, electrical current is transmitted on a number of different electrode types (e.g., steel cased wells and surface electrodes) while voltages are measured on all other electrodes, including the tanks. Data acquisition hardware and software allow for continuous real‐time monitoring of the received voltages and the leak assessment is conducted through a time‐series data analysis. The specific hardware and software combination creates a highly sensitive method of leak detection, complementing existing drywell logging as a means to detect and quantify leaks. Working in an industrial environment such as the Hanford site presents many challenges for electrical monitoring: cathodic protection, grounded electrical infrastructure, lightning strikes, diurnal and seasonal temperature trends, and precipitation, all of which create a complex environment for leak detection. In this discussion we present examples of challenges and solutions to working in the tank farms of the Hanford site.
ChemInform Abstract: Theoretical Study on the Mechanism of the Superacid‐Catalyzed Unimolecular Isomerization of n‐Butane and 1‐Butene (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Data from Targeting BET Proteins BRD2 and BRD3 in Combination with PI3K-AKT Inhibition as a Therapeutic Strategy for Ovarian Clear Cell Carcinoma (2023)

&lt;p&gt;Supplementary Figure 4. Dose-response curves of BET inhibitors JQ1 and CPI203 in OCCC cells.&lt;/p&gt;
Spectrum pool reassignment for wireless multi-hop relay systems (2008)

We consider a wireless multi-hop relay system that operates on secondary sharing basis in licensed spectrum. The system employs OFDM-based spectrum pooling to avoid harmful interference to licensed systems. An OFDM-based spectrum pool comprises of a set of OFDM subchannels that correspond to white space spectrum regions. The proposed relay system comprises of a source node that transmits data to a destination node in multi-hops using multiple relay nodes. Communication over node pairs occurs on an available spectrum pool. At each receiving intermediate node, received data symbols are amplified, permuted and then forwarded on. Spectrum pool reassignment comprises determination of the permutation mapping at each intermediate node. We consider the problem of maximizing the system capacity by determining the optimum spectrum pool reassignment. We show that each relay can determine the optimum permutation mapping based on the effective signal to noise ratios in the previous hops and the signal to noise ratio in the next hop, while preserving system optimality.
POPULATION STRUCTURE, PARASITISM, AND SURVIVORSHIP OF SEXUAL AND AUTODIPLOID PARTHENOGENETIC CAMPELOMA LIMUM (2000)

Two theories for the maintenance of sexual reproduction, the Red Queen hypothesis and mutation accumulation, suggest that the dispersal rates of sexuals and asexuals may determine the elimination or persistence of asexuals. Under higher dispersal rates of asexuals, asexuals may temporarily escape virulent parasites and reduce the effects of deleterious mutations. In the present study, I examine the population structure, parasite loads, and juvenile survivorship of Campeloma limum sexuals and autodiploid parthenogens from the southeastern U.S. Atlantic coastal plain. Using mtDNA sequence variation, it is shown that parthenogenetic haplotypes with limited sequence divergence are geographically widespread throughout this region and there is no significant population differentiation over a broad geographical scale. Sexual C. limum populations show significant mtDNA differentiation among and within river drainages and there is significant isolation by distance. These patterns are consistent with a recent origin and range expansion of parthenogens. Prevalence of infection by digenetic trematodes is significantly higher in autodiploid parthenogens, and the variance of prevalence is also higher in autodiploid parthenogens. I argue that the latter pattern indicates that unparasitized parthenogens have temporarily escaped these virulent parasites, but recolonization of these populations by trematodes results in high infection levels (> 40%), possibly due to reduced variation in resistance genes. I also examined whether the survivorship of juvenile sexuals and parthenogens varied under different stress levels. Sexual juveniles had twofold higher survivorship in all environments. Compared to polyploid parthenogens, autodiploid parthenogens may be less buffered against the effects of deleterious recessive alleles. I propose that the combined effects of higher parasitism and reduced juvenile survivorship of these autodiploid parthenogens accounts for the spatial distribution of sexual and parthenogenetic C. limum in the Atlantic coastal plain. Parthenogens may persist by higher dispersal rates into marginal habitats where there is a temporary escape from digenetic trematodes and competition with sexuals.Corresponding Editor: R. Burton
On the Relationship Between Sensory Eye Dominance and Stereopsis in the Normal-Sighted Adult Population: Normative Data (2018)

The extent of sensory eye dominance, a reflection of the interocular suppression in binocular visual processing, can be quantitatively measured using the binocular phase combination task. In this study, we aimed to provide a normative dataset for sensory eye dominance using this task. Based on that, we also assessed the relationship between perceptual eye dominance and stereopsis. One-hundred and forty-two adults (average age: 24.00 ± 1.74 years old) with normal or corrected to normal monocular visual acuity (logMAR < 0.00) participated. Observer's sensory eye dominance was quantified in two complementary ways: the interocular contrast ratio when the two eyes were balanced (i.e., the balance point) and the absolute value of the binocular perceived phase when each eye viewed maximum contrast stimuli in binocular phase combination task. Stereo acuities were measured with maximum contrast stimuli using an identical spatial frequency (0.30 cycles/degree) and stimulus arrangement to that used in the eye dominance assessment. The averaged balance point was 0.93 ± 0.06 (Mean ± SD), the averaged absolute value of the binocular perceived phase when both eyes viewed maximum contrast stimuli was 7.62 ± 5.91°, and the averaged stereo acuity was 2.19 ± 0.34 log arc seconds. Neither of these two sensory eye dominance measures were significantly correlated with stereo acuity (Balance point: <i>ρ</i> = 0.14, <i>P</i> = 0.10; Phase: <i>ρ</i> = -0.13, <i>P</i> = 0.13). The sensory eye dominance, as reflected using a phase combination task, and stereopsis are not significantly correlated in the normal-sighted population at low spatial frequencies.
Transcostal imaging with large coherent apertures: Ex vivo studies (2014)

In order to implement and evaluate a basic blocked-element detection and compensation algorithm on large arrays we acquired large synthetic 2-D aperture data sets on canine ribs ex vivo. Elements that were blocked by the ribs exhibited significantly lower values for the signal amplitude and nearest-neighbor cross-correlation than the remaining elements on the aperture. Turning off these elements retroactively in transmit and receive synthetic apertures significantly reduced clutter magnitude in the resulting B-mode images. Measured point spread functions showed now significant difference after blocked-element compensation was applied.
The Synthesis of Oxetane Monomers and their Polymerisation to give Side-Chain Liquid-Crystalline Polymers with Broad Smectic C Phases (1999)

Abstract A series of side-chain liquid-crystalline polymers has been synthesised from monomeric oxetanes. The synthesis and liquid crystal properties of the monomers and the polymers are discussed and it is shown that a short spacer unit can be used to obtain polymers with a flexible backbone which give broad liquid crystalline phases and low glass transition temperatures. Various initiators were used for the polymerisation but the photoinitiator “SARCAT KI 85TM”, a disulfonium salt, yielded the best results.
Flocculant Screening Method at Lab Scale for Application in Disc Stack Centrifuges with Hermetic Design (2018)

Chemicals produced using biotechnological methods like fermentation processes are obtained as complex diluted aqueous mixture, which still contains the production organism. Centrifugation is a commonly used technology for biomass separation. By flocculation, the settling velocity of microorganisms can be increased. Here, a laboratory flocculant screening method tailored for the separation of flocculated biomass in a fully hermetic disc stack centrifuge is described. The specific requirements of this process, namely, floc formation, floc stability, sliding behavior in the disc stack, and flowability of the sludge, were transferred to lab scale and validated in pilot tests. The qualitative results of the laboratory screening were in agreement with the processes at industrial scale.
Thermodynamic Ground States of Complex Oxide Heterointerfaces (2016)

The formation mechanism of 2-dimensional electron gases (2DEGs) at heterointerfaces between nominally insulating oxides is addressed with a thermodynamical approach. We provide a comprehensive analysis of the thermodynamic ground states of various 2DEG systems directly probed in high temperature equilibrium conductivity measurements. We unambiguously identify two distinct classes of oxide heterostructures: For epitaxial perovskite/perovskite heterointerfaces (LaAlO<sub>3</sub>/SrTiO<sub>3</sub>, NdGaO<sub>3</sub>/SrTiO<sub>3</sub>, and (La,Sr)(Al,Ta)O<sub>3</sub>/SrTiO<sub>3</sub>), we find the 2DEG formation being based on charge transfer into the interface, stabilized by the electric field in the space charge region. In contrast, for amorphous LaAlO<sub>3</sub>/SrTiO<sub>3</sub> and epitaxial γ-Al<sub>2</sub>O<sub>3</sub>/SrTiO<sub>3</sub> heterostructures, the 2DEG formation mainly relies on the formation and accumulation of oxygen vacancies. This class of 2DEG structures exhibits an unstable interface reconstruction associated with a quenched nonequilibrium state.