gebhart/patrepeval huggingface dataset:
Demo hour (2018)

forum Share on Demo hour Authors: Xuan Luo University of Washington University of WashingtonView Profile , Jason Lawrence Google GoogleView Profile , Steven M. Seitz University of Washington University of WashingtonView Profile , Anne-Claire Bourland University of Bristol University of BristolView Profile , Peter Gorman University of Bristol University of BristolView Profile , Jess McIntosh University of Bristol University of BristolView Profile , Asier Marzo University of Bristol University of BristolView Profile , Cheng-Te Chi Shih Chien University Shih Chien UniversityView Profile , Ian Gonsher Brown University Brown UniversityView Profile , Steve Kim Brown University Brown UniversityView Profile , McKenna Cisler Brown University Brown UniversityView Profile , Jonathan Lister Brown University Brown UniversityView Profile , Benjamin Navetta Brown University Brown UniversityView Profile , Peter Haas Brown University Brown UniversityView Profile , Ethan Mok Brown University Brown UniversityView Profile , Horatio Han Brown University Brown UniversityView Profile , Beth Phillips Brown University Brown UniversityView Profile , Maartje de Graaf Brown University Brown UniversityView Profile Authors Info & Claims InteractionsVolume 25Issue 4July - August 2018 pp 8–11https://doi.org/10.1145/3226034Published:27 June 2018Publication History 2citation563DownloadsMetricsTotal Citations2Total Downloads563Last 12 Months138Last 6 weeks16 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Fibre-optic PSK subcarrier transmission at 35 GHz using a resonantly enhanced semiconductor laser (1992)

The authors investigate the characteristics of directly modulated semiconductor lasers using a 35GHz subcarrier. They have achieved bit error rates of 10−10 for data transmission over short optical fibre links with a 35GHz subcarrier.
Modeling the VARTM Composite Manufacturing Process (2004)

A comprehensive simulation model of the VARTM composite manufacturing process has been developed. For isothermal resin infiltration, the model incorporates submodels which describe cure of the resin and changes in resin viscosity due to cure, resin flow through the reinforcement preform and distribution medium and compaction of the preform during the infiltration. The accuracy of the model was validated by measuring the flow patterns during resin infiltration of flat preforms. The modeling software was used to evaluate the effects of the distribution medium on resin infiltration of a flat preform. Different distribution medium configurations were examined using the model and the results were compared with data collected during resin infiltration of a carbon fabric preform. The results of the simulations show that the approach used to model the distribution medium can significantly effect the predicted resin infiltration times. Resin infiltration into the preform can be accurately predicted only when the distribution medium is modeled correctly.
Major copy proportion analysis of tumor samples using SNP arrays (2008)

MCP extends tumor LOH analysis to allelic imbalance analysis and supplies complementary information to total copy numbers. MCP analysis of mixing normal and tumor samples suggests the utility of MCP analysis of normal-contaminated tumor samples. The described analysis and visualization methods are readily available in the user-friendly dChip software.
Surface plasmon enhanced light emitting devices (2004)

By adding gold nanoparticles to the emissive layer of an electrophosphorescent light emitting diode, significant increase of the device efficiency was achieved due to acceleration of radiative rates caused by the interaction with surface plasmons.
Architectural Optimization for Low power in a Reconfigurable UMTS filter (2006)

This paper presents an improved architecture for an UMTS filter which reduces the switching power within the filter by 75% compared to the original design. The filter length is dynamically varied depending on the adjacent channel noise. This attains the least power consumption in noise free environments and required filter performance in the presence of noise. As a consequence, the battery life of the mobile device is improved without compromising with the 3GPP standard filter specifications. Furthermore, the design is simplified by reducing the number of clock domains from 3 to 2. In the improved design most blocks run at a slower clock, reducing switching power, and thus the overall power consumption.
Optical system designs based on bi-directional sensor devices (2012)

Small and compact optical system designs are needed in nearly all application scenarios of optical projection and imaging systems, e.g. automotive, metrology, medical or multimedia. Most active optical systems are based on separated imaging (e.g. camera unit) and image generating units (e.g. projection unit). This fact limits the geometrical miniaturization of the system. We present compact optical system designs using the new technology of bi-directional sensor devices. These devices combine light emitting and light detecting elements on one single chip. The application of such innovative opto-electronic devices - so-called bi-directional OLED microdisplays (BiMiDs) - offer a huge potential for miniaturization with a simultaneous increase of performance due to a new integration step. For these new bi-directional sensor devices new optical design concepts for simultaneous and sequential emission and detection are necessary. Because the simultaneous emission and detection can disturb the functionality of the optical system. New concepts has to be applied. A first concept is an exemplary 3-D metrology system applying fringe projection. A second concept is a pico-projection system with an integrated camera function. For both concepts the system configurations and the optical design are discussed. Due to the application of the bi-directional sensor device ultra-compact systems are presented.
Supplementary Figure 2 from Tumor-Specific CD8<sup>+</sup> T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts (2023)

Supplementary Figure 2 from Tumor-Specific CD8&lt;sup&gt;+&lt;/sup&gt; T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts
Early Carotid Endarterectomy after Ischemic Stroke Improves Diffusion/Perfusion Mismatch on Magnetic Resonance Imaging: Report of Two Cases (2003)

Carotid endarterectomy in the setting of diffusion-weighted/perfusion-weighted imaging mismatch can lead to improvement in cerebral perfusion as evidenced by resolution of the perfusion-weighted imaging lesion. Diffusion/perfusion magnetic resonance imaging may be useful in identifying patients with severe neurological deficits but without large territories of infarction who may safely undergo early surgical revascularization.
Automated Biochemical, Morphological, and Organizational Assessment of Precancerous Changes from Endogenous Two-Photon Fluorescence Images (2011)

A wealth of complementary morphological, biochemical and organizational tissue parameters can be extracted from high resolution images that are acquired based entirely on endogenous sources of contrast. They are promising diagnostic parameters for the non-invasive identification of early cancerous changes and could improve significantly diagnosis and treatment for numerous patients.
Pharmacology and Cell Biology of the Bombesin Receptor Subtype 4 (BB4-R) (1999)

Recently, a fourth member of the bombesin (Bn) receptor family (fBB4-R) was isolated from a cDNA library from the brain of the frog, Bombina orientalis. Its pharmacology and cell biology are largely unknown, and no known natural cell lines or tissues possess sufficient numbers of fBB4-R's to allow either of these to be determined. To address these issues, we have used three different strategies. fBB4-R expression in cells widely used for other Bn receptor subtypes was unsuccessful as was expression in two frog cell lines. However, stable fBB4-R cell lines were obtained in CHO-K1 cells which were shown to faithfully demonstrate the correct pharmacology of the related Bn receptor, the GRP receptor, when expressed in these cells. [DPhe6,betaAla11,Phe13,Nle14]Bn(6-14) was found to have high affinity (Ki = 0.4 nM) for the fBB4 receptor and 125I-[DTyr6,betaala11,Phe13,Nle14]Bn(6-14) to be an excellent ligand for this receptor. The fBB4-R had a unique pharmacology for naturally occurring Bn-related agonists, with the presence of a penultimate phenylalanine being critical for high-affinity interaction. It also had a unique profile for six classes of Bn antagonists. The fBB4-R was coupled to phospholipase C with activation increasing [3H]inositol phosphates and mobilizing Ca2+ almost entirely from cellular sources. There was a close correlation between agonist the receptor occupation and the receptor activation. Three of the five classes of Bn receptor antagonists that interacted with higher affinity with the fBB4-R functioned as fBB4-R antagonists and two as partial agonists. fBB4-R activation stimulated increases in phospholipase D (PLD) over the same range of concentrations at which it activated phospholipase C. These results demonstrate that the fBB4 receptor has a unique pharmacology for agonists and antagonists and is coupled to phospholipase C and D. The availability of these cell lines, this novel ligand, and the identification of three classes of antagonists that can be used as lead compounds should facilitate the further investigation of the pharmacology and cell biology of the BB4 receptor.
Photonic nanostructures and devices based on photonic crystals (2004)

Recent developments in the fabrication and light emission control of photonic crystals are described. Future photonic crystal studies promise the development of higher quality and more reliable devices with the aid of nanotechnology. In particular, 2D photonic crystal slab, in combination with Si LSI technology will proceed with an all-optical main part, but with electronic-driven control. Sensing applications, memory, single photon emitters, and other new application areas will also be developed since extremely high Q nanocavities has already been achieved. In the case of 3D photonic crystals, the fabrication technology will develop continuously and an ultimate control of photons will be demonstrated.
Supplementary Tables and Figures Legends from Bispecific Antibodies and Antibody–Drug Conjugates (ADCs) Bridging HER2 and Prolactin Receptor Improve Efficacy of HER2 ADCs (2023)

&lt;p&gt;Supplementary Tables and Figures Legends&lt;/p&gt;
Stratification of patients with lysosomal acid lipase deficiency by enzyme activity in dried blood spots (2022)

The new LAL enzymatic activity assay using the specific substrate offers an improved biochemical genetics method for the diagnosis of LAL-D in symptomatic patients and more importantly, for the prognosis of asymptomatic patients who test positive in population-wide LAL-D newborn screening.
Femtosecond X-ray induced changes of the electronic and magnetic response of solids from electron redistribution. (2019)

Resonant X-ray absorption, where an X-ray photon excites a core electron into an unoccupied valence state, is an essential process in many standard X-ray spectroscopies. With increasing X-ray intensity, the X-ray absorption strength is expected to become nonlinear. Here, we report the onset of such a nonlinearity in the resonant X-ray absorption of magnetic Co/Pd multilayers near the Co L[Formula: see text] edge. The nonlinearity is directly observed through the change of the absorption spectrum, which is modified in less than 40 fs within 2 eV of its threshold. This is interpreted as a redistribution of valence electrons near the Fermi level. For our magnetic sample this also involves mixing of majority and minority spins, due to sample demagnetization. Our findings reveal that nonlinear X-ray responses of materials may already occur at relatively low intensities, where the macroscopic sample is not destroyed, providing insight into ultrafast charge and spin dynamics.
Design of Maximum Directivity Beamformers With Linear Acoustic Vector Sensor Arrays (2023)

This paper studies the design of maximum directivity factor (MDF) beamformers based on uniform linear arrays (ULAs) consisting of acoustic vector sensors (AVSs). We first derive the main lobe constraints, which ensure that the beamformer's beampattern achieves a maximum in the look direction, and prove that any beamformer that satisfies the proposed constraints can be written as the sum of two orthogonal beamformers: the maximum white noise gain (MWNG) beamformer and a reduced-rank beamformer. Then, we derive the MDF beamformer by maximizing the directivity factor (DF) under the deduced constraints. We also derive a robust version of the MDF beamformer, which can keep the WNG above a pre-specified level. Compared to the conventional MDF beamformer based on ULAs with omnidirectional microphones, the designed MDF beamformer with uniform linear AVS arrays (ULAVSAs) can steer the beampattern to any look direction in the 3-dimensional space and achieves a higher directivity. The proposed MDF beamformer also outperforms the two-step MDF beamformer with ULAVSAs since it maximizes the DF. The proposed methods are validated through simulations as well as real experiments.
Intermediate basal cells of the prostate: In vitro and in vivo characterization (2003)

PrEC represents an epithelial population whose basal characteristics are modified in response to matrigel, stromal factors, and senescence, consistent with a transient amplifying population. These cells may derive from a previously unrecognized, involucrin-positive subset present in vivo.
P831 Gut mucosal virome alterations and loss of viral-bacterial interactions in ulcerative colitis (2019)

Ulcerative colitis (UC) is associated with gut microbiota dysbiosis. Although alterations in faecal bacteriome and virome have been reported, little is known of the composition and function of the mucosa virome in UC. This is the first study that aims to delineate the configuration and function of mucosal virome in human health and UC. We performed ultra-deep metagenomic sequencing of virus-like particle preparations and bacterial 16S rRNA sequencing on rectal tissues from 167 Chinese subjects (63 UC, 48 controls from Hong Kong; 20 UC, 20 controls from Beijing). We assessed mucosa virome and bacteriome alterations in UC and correlated alterations with patient meta-data. We also extrapolated mucosa virome enterotypes. In UC, there was an expansion of mucosal viruses, particularly Caudovirales bacteriophages, and a decrease in mucosa viral diversity, richness and evenness compared with healthy controls. Altered mucosa virome correlated with intestinal inflammation. Inter-individual dissimilarity between mucosal viromes was higher in UC than controls. Escherichia phage and Enterobacteria phage were more abundant in the mucosa of UC than controls (FDR adjusted p-value = 1.89e−18 and 4.50e−16, respectively). We clustered the mucosal viral communities of all study subjects into two enterotypes. Enterotype 2 viromes, predominated by UC subjects, displayed a significant loss of viral species. UC patients showed prominent abrogation of viral functions, whereas viral functions associated with bacterial fitness and pathogenicity were markedly enriched in UC mucosa. Intensive Trans-kingdom correlation between mucosa viruses and bacteria were observed in controls but these interactions were significantly lost in UC mucosa UC is characterised by mucosal virobiota dysbiosis with functional distortion. Enrichment of Caudovirales bacteriophages, increased phage/bacteria virulence functions, and loss of viral-bacterial interactions in UC mucosa suggest that dysbiotic mucosal viruses and bacteria may play an important role in UC pathogenesis.
Generation of a luciferase-based reporter for CHH and CG DNA methylation inArabidopsis thaliana (2013)

We developed a luciferase-based reporter system, LUCL, which reports both RdDM and CG maintenance methylation in Arabidopsis. The low basal level of LUCL expression provides an easy readout in genetic and chemical genetic screens that will dissect the mechanisms of RdDM and methylation maintenance.
Cover Picture: DNA Minicircles with Gaps for Versatile Functionalization / Construction of DNA Architectures with RNA Hairpins (Angew. Chem. Int. Ed. 5/2008) (2008)

Bind the gap …︁…︁ The cover picture shows an idealized rendering of a DNA minicircle (green) with a 21-nucleotide-long single-stranded region, or gap. M. Famulok and co-workers show in their Communication on page 967 ff. how these circles can be generated and visualized by atomic force microscopy. Any complementary oligonucleotide (red) can hybridize to the gap so that synthetic functional groups can be incorporated. In a second study on page 971 ff. they show that RNA molecules can also hybridize to form a heteroduplex with the gap, enabling the incorporation of nucleic acid motifs in DNA minicircles.
Remote Detection of HCN, HF, and Nerve Agent Vapors Based on Self-Referencing, Dye-Impregnated Porous Silicon Photonic Crystals (2020)

A one-dimensional photonic crystal is prepared from porous silicon (pSi) and impregnated with a chemically specific colorimetric indicator dye to provide a self-referenced vapor sensor for the selective detection of hydrogen fluoride (HF), hydrogen cyanide (HCN), and the chemical nerve agent diisopropyl fluorophosphate (DFP). The photonic crystal is prepared with two stop bands: one that coincides with the optical absorbance of the relevant activated indicator dye and the other in a spectrally "clear" region, to provide a reference. The inner pore walls of the pSi sample are then modified with octadecylsilane to provide a hydrophobic interior, and the indicator dye of interest is then loaded into the mesoporous matrix. Remote analyte detection is achieved by measurement of the intensity ratio of the two stop bands in the white light reflectance spectrum, which provides a means to reliably detect colorimetric changes in the indicator dye. Indicator dyes were chosen for their specificity for the relevant agents: rhodamine-imidazole (RDI) for HF and DFP, and monocyanocobinamide (MCbi) for HCN. The ratiometric readout allows detection of HF and HCN at concentrations (14 and 5 ppm, respectively) that are below their respective IDLH (immediately dangerous to life and health) concentrations (30 ppm for HF; 50 ppm for HCN); detection of DFP at a concentration of 114 ppb is also demonstrated. The approach is insensitive to potential interferents such as ammonia, hydrogen chloride, octane, and the 43-component mixture of VOCs known as EPA TO-14A, and to variations in relative humidity (20-80% RH). Detection of HF and HCN spiked into the complex mixture EPA TO-14A is demonstrated. The approach provides a general means to construct robust remote detection systems for chemical agents.
Comparison of the seventh and eighth edition american joint committee on cancer oral cavity staging systems (2018)

2c. Laryngoscope, 128:2351-2360, 2018.
Recording place cells from multiple sub-regions of the rat hippocampus with a customized micro-electrode array (2014)

The hippocampus is a subcortical structure which is involved in memory function. There is a considerable amount of evidence available which indicates that the hippocampal system is necessary for effective spatial learning in rodents and short-term topographical memory in human. Recordings of neural activities from the hippocampus of behaving animals can help us to understand how spatial information is encoded and processed by the hippocampus. In this work, we designed a triple-region microelectrode array (MEA) which took into concern the anatomical structures of the rat hippocampus. The array was composed of 16 stainless steel wires which were arranged into three groups that differed in length. Each group targeted one subregion of the hippocampus. The array was chronically implanted into the rat hippocampus through craniotomy. Neural activities were monitored both during the implantation and after recovery. The triple-region MEA was capable of recording unitary activities from multiple subregions of the rat hippocampus and the spatial distribution of firing rates were analyzed while the animal freely explored in the environment.
Mechanical and Dielectric Properties of Pure‐Silica‐Zeolite Low‐k Materials (2006)

Special k: Pure silica zeolites (PSZs) have been shown experimentally to display a remarkably higher elastic modulus than amorphous porous silicas at any given porosity or dielectric constant (k) value as a result of their crystalline structure. The combined experimental and theoretical findings suggest that PSZs have the necessary properties for use as the next generation of low-k insulators. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z602036_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The potential roles for herbicide-resistant crops in world agriculture (2018)

Herbicide-resistant crops (HRCs) should be a part of integrated weed management systems for sane management of human agricultural ecosystems. Subsidized agriculture in western Europe that rendered the use of even most expensive herbicides as cost effective led to multiple applications of herbicides on major crops such as com, wheat, and sugar beets. Sugar beets have been widely cultivated in Europe in heavily subsidized manner and the price of production is higher than world sugar prices. 2,4-Dichlorophenoxyacetic acid (2,4-D) has been the standard for broadleaf control in wheat for fifty years. It has low selection pressure, both because of imperfect kill and because weeds in many ecosystems can germinate after it has dissipated, diluting resistance. Triallate is a thiocarbamate herbicide widely used to control wild oats in small grains. There are only two other groups of metabolically selective herbicides for wild oats, one of the most pernicious grass weeds of wheat: various inhibitors of acetyl coenzyme A carboxylase (ACCase) and isoproturon.
Deterministic Access of High-Power, Normal-GVD Kerr-Comb States (2023)

We demonstrate a deterministic and repeatable pathway to access single and multi-free-spectral range states with normal-GVD Kerr combs. A key component to stabilizing the high-power comb states is implementation of a drop port on the auxiliary resonator.
Nanofabrication Using Scanning Near-Field Optical Microscopy (1998)

The interest in extremely small solid-state devices and high-density data storage has increased rapidly. To realize such applications, new techniques for fabricating nanometer-scale structures are important, because the conventional optical lithography has an insufficient resolution limited by the wavelength of the light and the numerical aperture of the lenses.
Supplementary Method M1 from Nonclinical Development of Next-generation Site-specific HER2-targeting Antibody–drug Conjugate (ARX788) for Breast Cancer Treatment (2023)

&lt;p&gt;Supplementary Method 1 describes bioanalysis for ARX788, Total Antibody, and pAF-AS269&lt;/p&gt;
Correction to “Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure” (2017)

[This corrects the article DOI: 10.1021/acsmedchemlett.6b00481.].