gebhart/patrepeval huggingface dataset:
Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells (2014)

Resistance of cancer cells to chemotherapy is a significant problem in oncology, and the development of sensitising agents or small-molecules with new mechanisms of action to kill these cells is needed. Autophagy is a cellular process responsible for the turnover of misfolded proteins or damaged organelles, and it also recycles nutrients to maintain energy levels for cell survival. In some apoptosis-resistant cancer cells, autophagy can also enhance the efficacy of anti-cancer drugs through autophagy-mediated mechanisms of cell death. Because the modulation of autophagic processes can be therapeutically useful to circumvent chemoresistance and enhance the effects of cancer treatment, the identification of novel autophagic enhancers for use in oncology is highly desirable. Many novel anti-cancer compounds have been isolated from natural products; therefore, we worked to discover natural, anti-cancer small-molecule enhancers of autophagy. Here, we have identified a group of natural alkaloid small-molecules that function as novel autophagic enhancers. These alkaloids, including liensinine, isoliensinine, dauricine and cepharanthine, stimulated AMPK-mTOR dependent induction of autophagy and autophagic cell death in a panel of apoptosis-resistant cells. Taken together, our work provides novel insights into the biological functions, mechanisms and potential therapeutic values of alkaloids for the induction of autophagy.
A 1 V multi-threshold voltage CMOS DSP with an efficient power management technique for mobile phone application (2002)

A low-power digital signal processor (DSP) is the key component for battery-driven mobile phone equipment since a vast amount of data needs to be processed for multimedia use. Reduced supply voltage is a direct approach to power reduction. This 1 V DSPLSI with 26 MOPS and 1.1 mW/MOPS performance adopts a multi-threshold-voltage CMOS (MTCMOS) technique. A small embedded power-management processor decreases power during waiting periods.
CD86 (B7-2), but Not CD80 (B7-1), Expression in the Epidermis of Transgenic Mice Enhances the Immunogenicity of Primary CutaneousCandida albicansInfections (1998)

Transgenic (Tg) mice whose epidermal keratinocytes constitutively overexpress either B7-1 (CD80) or B7-2 (CD86) exhibited exaggerated cutaneous delayed type hypersensitivity (DTH) to haptens compared to non-Tg mice. To determine whether enhanced DTH in these Tg mice is seen in response to cutaneous fungal infections, a primary infection with Candida albicans was established by inoculating this organism on the occluded skin of Tg and non-Tg mice. These infections resolved 7 days after removal of occlusive dressing in all three groups of mice, without evidence of exaggerated inflammation in either the Tg or non-Tg mice. Only B7-2 Tg mice developed enhanced Th1-lymphocyte-mediated immune responses to C. albicans antigens after resolving this infection: enhanced footpad swelling in response to intradermal C. albicans antigens, enhanced production of mRNA encoding Th1 lymphokines in draining lymph nodes, and increased gamma interferon secreted into culture supernatants by lymph node T lymphocytes stimulated with Candida antigens in vitro. Lastly, Western blotting of sera from mice that had resolved this fungal infection indicated that only B7-2 Tg mice recognized a wide range of Candida-associated antigens. These data suggest that these two costimulatory molecules, when expressed by keratinocytes, do not deliver identical signals to C. albicans antigen-reactive Th1 lymphocytes. The enhanced immune response in B7-2 Tg mice to a cutaneous C. albicans infection demonstrates the importance of antigen presentation and costimulation in immune reactivity to fungi. Furthermore, B7-2 Tg mice may be useful in identification of protective Candida antigens.
In situ scanning electron microscopy of hydrogen embrittlement by near atmospheric-pressure hydrogen microplasma jet (2023)

Elucidation of microstructures responsible for hydrogen embrittlement is hoped for research and development of high-strength low-alloy steel. For this purpose, a novel in situ scanning electron microscopy method of hydrogen embrittlement was developed by using a near atmospheric-pressure hydrogen microplasma jet excited by pulsed glow discharge. By the developed method, propagations of hydrogen embrittlement cracks in typical martensitic steel, Japanese Industrial Standards SCM435 steel, were successfully observed at frame rates at least up to 10.2 Hz with the same image quality as in high vacuum. The hydrogen microplasma jet neither elevated the specimen temperature nor damaged the specimen surface. Strain evolution prior to the crack propagations was also successfully observed in conjunction with the digital image correlation technique. It was found that a small electron scattering cross section of the hydrogen molecule, a large density of hydrogen ions in the near atmospheric-pressure microplasma jet, and stabilization of the glow discharge by the electron beam of the scanning electron microscope play a crucial role in the realization of the in situ observations.
Efficient tool path generation for five-axis machining of a difficult machined centrifugal impeller (2017)

This article presents an efficient tool path generation method for five-axis machining of a difficult machined centrifugal impeller. Geometry of centrifugal impeller is analyzed, and the inherent low efficiency of the machining of difficult machined centrifugal impeller is obtained. The tool path curves which are calculated by the most common iso-parametric method are shown to testify the waste in machining. The new type machining layers are calculated, and the new machining regions are achieved. The new tool path curves in each new machining region are calculated, and they are sparser and triangular. For the inherent low machining efficiency of difficult machined centrifugal impeller, the machining time can be greatly reduced just by the optimizing tool path generation method in this article. Numerical simulation and a real test impeller are presented as the test of the proposed method.
Study of the impact of dielectric aging on coplanar waveguide performance (2015)

In this paper, we study the impact of electrical and thermal stress on line loss and characteristic impedance of a CoPlanar Waveguides (CPWs). The de-rating of the line propagation constants and impedance characteristic are analyzed and discussed with respect to the stress level applied to the dielectric. The physical mechanisms leading to dielectric properties variation is explained.
Bayesian Joint Synchronization and Localization Based on Asymmetric\n Time-stamp Exchange (2020)

In this work, we study the joint synchronization and localization (sync&amp;loc)\nof Mobile Nodes (MNs) in ultra dense networks. In particular, we deploy an\nasymmetric timestamp exchange mechanism between MNs and Access Nodes (ANs),\nthat, traditionally, provides us with information about the MNs' clock offset\nand skew. However, information about the distance between an AN and a MN is\nalso intrinsic to the propagation delay experienced by exchanged time-stamps.\nIn addition, we utilize Angle of Arrival (AoA) estimation to determine the\nincoming direction of time-stamp exchange packets, which gives further\ninformation about the MNs' location. Finally, we employ Bayesian Recursive\nFiltering (BRF) to combine the aforementioned pieces of information and jointly\nestimate the position and clock parameters of MNs. The simulation results\nindicate that the Root Mean Square Errors (RMSEs) of position and clock offset\nestimation are kept below 1 meter and 1 ns, respectively.\n
Binocular open-view Shack-Hartmann wavefront sensor with consecutive measurements of near triad and spherical aberration (2008)

We have developed a binocular open-view Shack-Hartmann wavefront sensor for measuring time variation of binocular accommodation, vergence, pupil sizes (i.e., the binocular near triad), and monochromatic aberrations. The device measures these values16 times per second for up to 1 min. Our purpose is to introduce the new instrument. We have confirmed the accuracy of the device. Refractions for a 4 mm pupil were accurate across the range of measurements of model eyes and normal human eyes. We measured binocular dynamics of accommodation, vergence, and spherical aberrations.
The use of a removable appliance to improve oral continence in an elderly dentate patient. (2004)

Challenges in the treatment of our older dentate patients are arising more frequently, and novel solutions may be required to overcome them. This case report describes the treatment given to an elderly dentate female patient, whose lax peri-oral musculature was preventing a satisfactory oral seal from being achieved. This resulted in constant "drooling" and much social disability in an otherwise fit and gregarious lady. A simple removable appliance was provided to increase support to the tissues at the angles of the mouth. An immediate relief of the salivary leakage was achieved and maintained. Simple solutions may be available to problems which may cause great distress to our patients reducing the quality of their lives. This solution to the problem of peri-oral leakage, of a normal volume of saliva, may be useful for many other patients with similar problems, following loss of peri-oral muscle tone with age.
Data from Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Activating CSF-1–Mediated Macrophage Infiltration (2023)

&lt;div&gt;Abstract&lt;p&gt;Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show how the integrin-regulatory protein kindlin-2 (FERMT2) promotes metastatic progression of breast cancer through the recruitment and subversion of host macrophages. Kindlin-2 expression was elevated in breast cancer biopsy tissues where its levels correlated with reduced patient survival. On the basis of these observations, we used CRISPR/Cas9 technology to ablate Kindlin-2 expression in human MDA-MB-231 and murine 4T1 breast cancer cells. Kindlin-2 deficiency inhibited invasive and migratory properties &lt;i&gt;in vitro&lt;/i&gt; without affecting proliferation rates. However, &lt;i&gt;in vivo&lt;/i&gt; tumor outgrowth was inhibited by &gt;80% in a manner associated with reduced macrophage infiltration and secretion of the macrophage attractant and growth factor colony-stimulating factor-1 (CSF-1). The observed loss of CSF-1 appeared to be caused by a more proximal deficiency in TGFβ-dependent signaling in Kindlin-2–deficient cells. Collectively, our results illuminate a Kindlin-2/TGFβ/CSF-1 signaling axis employed by breast cancer cells to capture host macrophage functions that drive tumor progression. &lt;i&gt;Cancer Res; 77(18); 5129–41. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Cardiac Papillary Fibroelastoma (1996)

Papillary fibroelastomas are rare and benign heart tumors. We present two cases with these lesions. A young female patient with cerebral infarction was operated to resect the tumor on the mitral valve and the valve was successfully repaired. Another male patient had a history of bradycardia. On examination, coronary stenosis and a tumor in the left ventricle was found. Tumor excision combined with aorto-coronary artery bypass grafting was performed. Echocardiography proved to be highly effective to diagnose these tumors. Because of the potential cerebral and coronary embolization, these tumors should be excised. Surgical results are good.
Acute dialysis quality initiative (ADQI) (2001)

A new star is born. Its name is ADQI which stands for Acute Dialysis Quality Initiative. In the rmament of guidelines and directions for appropriate management of renal diseases, little has been done so far concerning acute renal failure and its treatment. For this reason we felt that a process seeking consensus and evidencebased statements in the eld of acute renal failure was needed.
Weyl points in photonic-crystal superlattices (2015)

In this paper, we show that Weyl points can be realized in all-dielectric superlattices based on three-dimensional (3D) layered photonic crystals. Our approach is based on creating an inversion-breaking array of weakly-coupled planar defects embedded in a periodic layered structure with a large omnidirectional photonic band gap. Using detailed band structure calculations and tight-binding theory arguments, we demonstrate that this class of layered systems can be tailored to display 3D linear point degeneracies between two photonic bands, without breaking time-reversal symmetry and using a configuration that is readily-accessible experimentally. These results open new prospects for the observation of Weyl points in the near-infrared and optical regimes and for the application of Weyl-physics in integrated photonic devices.
Multi-point interactions with immersive omnidirectional visualizations in a dome (2010)

This paper describes an interactive immersive experience using mid-air gestures to interact with a large curved display: a projected dome. Our Pinch-the-Sky Dome is an immersive installation where several users can interact simultaneously with omnidirectional data using freehand gestures. The system consists of a single centrally-located omnidirectional projector-camera unit where the projector is able to project an image spanning the entire 360 degrees and a camera is used to track gestures for navigation of the content. We combine speech commands with freehand pinch and clasping gestures and infra-red laser pointers to provide a highly immersive and interactive experience to several users inside the dome, with a very wide field of view for each user. The interactive applications include: 1) the astronomical data exploration, 2) social networking 3D graph visualizations, 3) immersive panoramic images, 4) 360 degree video conferencing, 5) a drawing canvas, and 6) a multi-user interactive game. Finally, we discuss the user reactions and feedback from two demo events where more than 1000 people had the chance to experience our work.
Visuelle Analyse von RFID-Sensordaten mit Raum- und Zeitbezug zur Untersuchung von Mausbewegungen (2008)

Position data of in cage living mice by using RFID technology were collected in order to distinguish behaviour of healthy and ill (infected with Alzheimer s disease) animals. Due to the extensive amount of per-millisecond log entries visualization is used to analyse the log data. Already by visualizing distances run by mice differences between ill and healthy or female and male respectively can be found. Furthermore visits of water places are examined to find changes in drinking habits. Additionally average daily routines were used for clustering and resulted in a correct partition of parts of the data. The best classification of all mice could be found by using temporal and geospatial dimensions at the same time. Lifelong visualizations of mice were generated by partitioning the lifetime and combining them within one image. All mice could be separated best by their gender, because the differences between the genders were much bigger than the differences between the ill and healthy mice.
Paper #194: Long‐Term Results of Latarjet Procedure for the Treatment of Anterior Glenohumeral Instability (2013)

Latarjet procedure for anterior glenohumeral instability provides excellent long-term results. The prevalence of postoperative development of arthritis is 17.6% at 20 years follow-up, but no severe arthritis like stage 4. Arthritic risk factors were old age at final follow-up, high demand sports activity after surgery and lateral overhang of coracoid bone graft.
Improving the perceptual quality of ideal binary masked speech (2017)

It is known that applying a time-frequency binary mask to very noisy speech can improve its intelligibility but results in poor perceptual quality. In this paper we propose a new approach to applying a binary mask that combines the intelligibility gains of conventional binary masking with the perceptual quality gains of a classical speech enhancer. The binary mask is not applied directly as a time-frequency gain as in most previous studies. Instead, the mask is used to supply prior information to a classical speech enhancer about the probability of speech presence in different time-frequency regions. Using an oracle ideal binary mask, we show that the proposed method results in a higher predicted quality than other methods of applying a binary mask whilst preserving the improvements in predicted intelligibility.
Phosphatidylinositol monophosphate-binding interface in the oomycete RXLR effector AVR3a is required for its stability in host cells to modulate plant immunity (2011)

The oomycete pathogen Phytophthora infestans causes potato late blight, one of the most economically damaging plant diseases worldwide. P. infestans produces AVR3a, an essential modular virulence effector with an N-terminal RXLR domain that is required for host-cell entry. In host cells, AVR3a stabilizes and inhibits the function of the E3 ubiquitin ligase CMPG1, a key factor in host immune responses including cell death triggered by the pathogen-derived elicitor protein INF1 elicitin. To elucidate the molecular basis of AVR3a effector function, we determined the structure of Phytophthora capsici AVR3a4, a close homolog of P. infestans AVR3a. Our structural and functional analyses reveal that the effector domain of AVR3a contains a conserved, positively charged patch and that this region, rather than the RXLR domain, is required for binding to phosphatidylinositol monophosphates (PIPs) in vitro. Mutations affecting PIP binding do not abolish AVR3a recognition by the resistance protein R3a but reduce its ability to suppress INF1-triggered cell death in planta. Similarly, stabilization of CMPG1 in planta is diminished by these mutations. The steady-state levels of non-PIP-binding mutant proteins in planta are reduced greatly, although these proteins are stable in vitro. Furthermore, overexpression of a phosphatidylinositol phosphate 5-kinase results in reduction of AVR3a levels in planta. Our results suggest that the PIP-binding ability of the AVR3a effector domain is essential for its accumulation inside host cells to suppress CMPG1-dependent immunity.
272: Cancer Characteristics and Cancer Control in Men with PSA of 4 Ngzml or Less Treated with Radical Prostatectomy (RP) (2005)

You have accessJournal of UrologyModerated Poster, Sunday, May 22, 2005 8:00 - 10:00 am1 Apr 2005272: Cancer Characteristics and Cancer Control in Men with PSA of 4 Ngzml or Less Treated with Radical Prostatectomy (RP) Bobby Shayegan, Fernando J. Bianco, James A. Eastham, and Peter T. Scardino Bobby ShayeganBobby Shayegan More articles by this author , Fernando J. BiancoFernando J. Bianco More articles by this author , James A. EasthamJames A. Eastham More articles by this author , and Peter T. ScardinoPeter T. Scardino More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34537-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "272: Cancer Characteristics and Cancer Control in Men with PSA of 4 Ngzml or Less Treated with Radical Prostatectomy (RP)." The Journal of Urology, 173(4S), p. 75 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 75 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Bobby Shayegan More articles by this author Fernando J. Bianco More articles by this author James A. Eastham More articles by this author Peter T. Scardino More articles by this author Expand All Advertisement PDF downloadLoading ...
Supply-Scaling for Efficiency Enhancement in Distributed Power Amplifiers (2016)

Distributed amplifiers (DAs) feature large bandwidth but relatively low gain and power efficiency. This paper presents a supply-scaling technique to improve the efficiency of a mm-wave DA while maintaining a broadband $50\Omega $ match. An analysis of interstage load modulation and the effects of shunt dc-feed inductors on distributed operation is provided. A single-ended, eight-stage DA is designed in a 90 nm SiGe BiCMOS process. The fabricated amplifier has a gain of 12 dB over a 3 dB bandwidth from 14-105 GHz. The measured peak output power is 17 dBm with a peak power-added efficiency (PAE) of 12.6% at 50 GHz and 3 dB power bandwidth greater than 70 GHz. The DA occupies an area of 2.65 mm × 0.57 mm, and total dc power consumed from four scaling voltage supplies is 297 mW.
The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods (2018)

Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.
Susceptibility of Human Immunodeficiency Virus Type 1 to the Maturation Inhibitor Bevirimat Is Modulated by Baseline Polymorphisms in Gag Spacer Peptide 1 (2009)

In this study, we evaluated baseline susceptibility to bevirimat (BVM), the first in a new class of antiretroviral agents, maturation inhibitors. We evaluated susceptibility to BVM by complete gag genotypic and phenotypic testing of 20 patient-derived human immunodeficiency virus type 1 isolates and 20 site-directed mutants. We found that reduced BVM susceptibility was associated with naturally occurring polymorphisms at positions 6, 7, and 8 in Gag spacer peptide 1.
ChemInform Abstract: Nucleophilic Perfluoroalkylation Using Perfluoroalkyllithiums (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Syntheses of 11C- and 18F-labeled carboxylic esters within a hydrodynamically-driven micro-reactor (2004)

Carboxylic esters were successfully labeled with one of two short-lived positron-emitters, carbon-11 or fluorine-18, within a hydrodynamically-driven micro-reactor. The non-radioactive methyl ester was obtained at room temperature; its yield increased with higher substrate concentration and with reduced infusion rate. Radioactive methyl ester was obtained from the reaction of (10 mM) with in 56% decay-corrected radiochemical yield (RCY) at an infusion rate of 10 microL min(-1), and when the infusion rate was reduced to 1 microL min(-1), the RCY increased to 88%. The synthesis of the non-radioactive fluoroethyl ester from and required heating of the micro-reactor on a heating block at 80 degrees C (14-17% RCY), whilst the corresponding radioactive from and was obtained in 10% RCY. The radioactive 'peripheral' benzodiazepine receptor ligand was obtained from the reaction of acid with labeling agent in 45% RCY at an infusion rate of 10 microL min(-1). When the infusion rate was reduced to 1 microL min(-1), the RCY increased to 65%. The results exemplify a new methodology for producing radiotracers for imaging with positron emission tomography that has many potential advantages, including a requirement for small quantities of substrates, enhanced reaction, rapid reaction optimisation and easy product purification.