gebhart/patrepeval huggingface dataset:
Gene-Modified Adult Stem Cells Regenerate Vertebral Bone Defect in a Rat Model (2011)

Vertebral compression fractures (VCFs), the most common fragility fractures, account for approximately 700,000 injuries per year. Since open surgery involves morbidity and implant failure in the osteoporotic patient population, a new minimally invasive biological solution to vertebral bone repair is needed. Previously, we showed that adipose-derived stem cells (ASCs) overexpressing a BMP gene are capable of inducing spinal fusion in vivo. We hypothesized that a direct injection of ASCs, designed to transiently overexpress rhBMP6, into a vertebral bone void defect would accelerate bone regeneration. Porcine ASCs were isolated and labeled with lentiviral vectors that encode for the reporter gene luciferase (Luc) under constitutive (ubiquitin) or inductive (osteocalcin) promoters. The ASCs were first labeled with reporter genes and then nucleofected with an rhBMP6-encoding plasmid. Twenty-four hours later, bone void defects were created in the coccygeal vertebrae of nude rats. The ASC-BMP6 cells were suspended in fibrin gel (FG) and injected into the bone void. A control group was injected with FG alone. The regenerative process was monitored in vivo using microCT, and cell survival and differentiation were monitored using tissue specific reporter genes and bioluminescence imaging (BLI). The surgically treated vertebrae were harvested after 12 weeks and subjected to histological and immunohistochemical (against porcine vimentin) analyses. In vivo BLI detected Luc-expressing cells at the implantation site over a 12-week period. Beginning 2 weeks postoperatively, considerable defect repair was observed in the group treated with ASC-BMP6 cells. The rate of bone formation in the stem cell-treated group was two times faster than that in the FG-treated group, and bone volume at the end point was 2-fold compared to the control group. Twelve weeks after cell injection the bone volume within the void reached the volume measured in native vertebrae. Immunostaining against porcine vimentin indicated that the ASC-BMP6 cells contributed to new bone formation. Here we show the potential of injections of BMP-modified ASCs to repair vertebral bone defects in a rat model. Our results could pave the way to a novel approach for the biological treatment of traumatic and osteoporosis-related vertebral bone injuries.
Calibration of Room Temperature Magnetic Sensor Array for Biomagnetic Measurement (2019)

Biomagnetic field measurement is a promising tool for the investigation of electrical activities in a living body. Room temperature (RT) magnetic sensors with an improved resolution such as magnetoresistance (MR) devices have been recently employed for the detection of weak magnetic fields, which were earlier detected solely using superconducting interference device magnetic sensors. The position, orientation, and sensitivity of each magnetic sensor in a sensor array must be precisely determined for accurate magnetic source analysis. We proposed a calibration method using an array of multiple coils, which is applicable to an RT magnetic sensor array. To demonstrate the validity of the proposed calibration method, we applied it to an MR device-based magnetocardiography (MCG) system equipped with an L-shaped planar sensor array, which was newly developed for the simultaneous observation of both anterior and lateral sides of the body. The deviation of the sensor parameters from the designed values was estimated via calibration. The result of the marker coil localization test indicated that the calibration considerably improved the accuracy of the magnetic source analysis. Finally, we demonstrated a preliminary MCG measurement using the calibrated magnetic sensor array.
Gas-phase reactions of doubly charged alkaline earth and transition metal complexes of acetonitrile, pyridine, and methanol generated by electrospray ionization (1997)

Formation and low energy collision-induced dissociation (CID) of doubly charged metal(II) complexes ([metal(II)+Ln]2+, metal(II)=Co(II), Mn(II), Ca(II), Sr(II) and L = acetonitrile, pyridine, and methanol) were investigated. Complexes of [metal(II)+Ln]2+ where n≤7 were obtained using electrospray ionization. Experimental parameters controlling the dissociation pathways for [Co(II)+(CH3CN)2]2+ were studied and a strong dependence of these processes on the collision energy was found. However, the dissociation pathways appear to be independent of the cone potential, indicating low internal energy of the precursor ions. In order to probe how these processes are related to intrinsic parameters of the ligand such as ionization potential and metal ion coordination, low energy CID spectra of [metal(II)+Ln]2+ for ligands such as acetonitrile, pyridine, and methanol were compared. For L = pyridine, all metals including the alkaline earth metals Ca and Sr were reduced to the bare [metal(I)]+ species. Hydride transfer was detected upon low energy CID of [metal(II)+Ln]2+ for metal(II)=Co(II) and Mn(II) and L = methanol, and corroborated by signals for [metal(II)+H−]+ and [metal(II)+H−+CH3OH]+, as well as by the complementary ion [CH3O]+.
A study of fouling and its effects on the performance of counter flow wet cooling towers (2004)

Fouling of fills is one of the most important factors affecting cooling tower thermal performance, reducing the effectiveness and capability of the cooling tower. In this paper, experimental data on fill fouling that have been reported in the literature are used to develop a fouling model. The model predicts the decrease in the fill performance index, n F , with the growth of fouling on fill materials. The authenticity of the fouling model is validated by experimental data. The fouling model, in conjunction with a detailed model of a counterflow wet cooling tower, is used to study the effect of fouling on cooling tower effectiveness and water outlet temperature. The models are used for studying the performance of small and medium-sized cooling towers under different air inlet wet-bulb temperatures. The results demonstrate that fouling of fills negates any gains in cooling tower performance that result from decreasing values of air inlet wet-bulb temperature. Furthermore, it is demonstrated that this effect is more pronounced in medium-sized cooling towers compared with small towers. Water outlet temperature decreases by 23.5 per cent in the case of small cooling towers, compared with an 18.3 per cent decrease for medium-sized towers under similar operating conditions.
ADAM (2008)

Design-time decisions can often only cover certain scenarios and fail in efficiency when hard-to-predict system scenarios occur. This drives the development of run-time adaptive systems. To the best of our knowledge, we are presenting the first scheme for a run-time application mapping in a distributed manner using agents targeting for adaptive NoC-based heterogeneous multi-processor systems. Our approach reduces the overall traffic produced to collect the current state of the system (monitoring-traffic), needed for runtime mapping, compared to a centralized mapping scheme. In our experiment, we obtain 10.7 times lower monitoring traffic compared to the centralized mapping scheme proposed in [8] for a 64 x 64 NoC. Our proposed scheme also requires less execution cycles compared to a non-clustered centralized approach. We achieve on an average 7.1 times lower computational effort for the mapping algorithm compared to the simple nearest-neighbor (NN) heuristics proposed in [6] in a 64 x 32 NoC. We demonstrate the advantage of our scheme by means of a robot application and a set of multimedia applications and compare it to the state-of-the-art run-time mapping schemes proposed in [6, 8, 19].
Supplementary Figure 4 from Angiopoietin-2 Functions as a Tie2 Agonist in Tumor Models, Where It Limits the Effects of VEGF Inhibition (2023)

&lt;p&gt;PDF file - 292K, Histological analysis of the effect of REGN910 + ZALTRAP� combination treatment on endothelial cell death&lt;/p&gt;
A convenient method for genetic incorporation of multiple noncanonical amino acids into one protein in Escherichia coli (2010)

By overexpressing the C-terminal domain of the ribosomal protein L11 to decrease release factor 1-mediated termination of protein translation, enhanced amber suppression is achieved in E. coli. This enhanced amber suppression efficiency allows the genetic incorporation of three N(epsilon)-acetyl-l-lysines into one GFP(UV) protein in E. coli.
Disorders of renal calcium handling, urinary stones, and nephrocalcinosis (2020)

Abstract Renal stones are common, with a prevalence of 5 to 10% worldwide. Acute stone passage almost always produces the severe pain of renal colic, but stones are often asymptomatic and discovered incidentally on imaging. Prevalence of both symptomatic and asymptomatic disease appears to be rising, although the relative contributions of increasing use of more sensitive imaging modalities and real changes relating to diet and lifestyle are debated. The initial evaluation of patients with renal colic optimally includes noncontrast CT to accurately visualize the size and location of stones in the urinary tract. Initial management of stones less than 5 mm in diameter in patients without anatomical abnormalities of the urinary tract is to provide adequate analgesia coupled with α-blockade, followed by watchful waiting to allow time for stone passage. The presence of urinary tract infection, inability to take oral fluids, or obstruction of a single functioning kidney requires hospitalization and active management. Once the acute episode of stone passage or removal is over, thought should be given to diagnosis of the underlying causes and steps taken towards prevention. Since stone analysis is the cornerstone of diagnosis, the patient should be encouraged to collect any stones passed and retain them for analysis. Most stones (66–76%) are formed of calcium oxalate: other types include calcium phosphate (12–17%), uric acid (7–11%), struvite (magnesium ammonium phosphate, 2–3%), and cystine (1–2%). They form because urine becomes supersaturated with respect to the solute, and treatment to lower its concentration can prevent recurrence. This chapter describes the aetiology, pathogenesis, diagnosis and treatment of calcium oxalate stones, calcium phosphate stones, uric acid stones, struvite stones, cystine stones, and nephrocalcinosis.
Sputtered tantalum photonic crystal coatings for high-temperature energy conversion applications (2015)

Thick sputtered tantalum (Ta) photonic crystal (PhC) coatings on Inconel were investigated as a potential replacement for bulk refractory metal substrates used for high-temperature emitters and absorbers in thermophotovoltaic energy conversion applications, where high-temperature stability and high reflectance of the surface in the infrared wavelength range are critical in order to sustain high operational temperatures and reduce losses due to waste heat. A selective emitter and solar absorber 2D PhC were fabricated in 8 and 30 micron sputtered Ta coatings, respectively, using standard semiconductor processes as a proof of concept. The fabricated PhCs showed high spectral selectivity in good agreement with the numerical simulations. The PhCs, coated with a thin HfO2 protective layer, sustained one hour anneals at 700, 900, and 1100°C with very little structural degradation or change in their optical properties. This study presents a promising alternative to bulk substrates as a relatively low-cost and easily integrated platform for nano-structured devices for high-temperature applications.
Quantitative and simultaneous measurement of oxygen consumption rates in rat brain and skeletal muscle using 17O MRS imaging at 16.4T (2020)

We have evaluated the feasibility of <sup>17</sup> O MRSI for imaging and quantifying the oxygen consumption rate in low metabolizing organs such as the skeletal muscle at rest. Additionally, we have shown that CBF is slightly increased in the case of ventilation with N<sub>2</sub> O. We expect this study to be beneficial to the application of <sup>17</sup> O MRSI to a wider range of organs, although further validation is advised.
Resonant coupling between a subwavelength metal patch perfect absorbing metamaterial and molecular resonance (2016)

Coupling between vibrational modes and metamaterial structures has a varied range of applications including, but not limited to, surface-enhanced vibrational spectroscopy and biological sensing. This endeavor investigates, via finite element method (FEM) and temporal coupled mode theory (TCMT), a subwavelength perfect absorbing metamaterial (PAMM) coupling to a carbon double oxygen bond (C=O) in Poly(methyl methacrylate) (PMMA) that resides at 52 THz or 1733 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> .
Modulation of metabolism ofClostridium acetobutylicum grown in chemostat culture in a three-electrode potentiostatic system with methyl viologen as electron carrier (1996)

The metabolism of Clostridium acetobutylicum was manipulated in chemostat culture at pH 5 and 6.5 in a three-electrode potentiostatic system with methyl viologen (MV) as the electron carrier. When a constant potential was applied at pH 5, the broth redox potential continuously decreased and, simultaneously, a high increase in the reduced MV concentration (MV(+.)) and the specific rate of butanol production was observed while butyric acid was taken up. A linear relationship was reported between the specific rate of NAD(P)(+) reduction by ferredoxin-NAD(P)(+) reductase and the broth redox potential, as long as the growth rate was not affected. To reach a steady state in glucose limited culture, a control system of the redox potential was required. However, it seems that C. acetobutylicum is able to adapt its metabolism when the broth redox potential was regulated at low value. On the other hand, at pH 6.5, the current generated by the electrochemical device had no effect either on broth redox potential and MV(+.) concentration or on the metabolism.
Self-Calibrated Pulse Oximetry Development Applied to Data from Human Freedivers (2022)

We developed an algorithm for pulse oximetry where the wavelength dependent photon pathlength is not assumed to be constant. Applying it to breath-holding freedivers, we found it capturing the change in arterial oxygen saturation accurately.
Synthesis of Vicinal Amino Alcohols via a Tandem Acylnitrene Aziridination−Aziridine Ring Opening (1997)

A facile synthesis of differently substituted vicinal amino alcohols is reported. We have demonstrated that these amino alcohols could be readily prepared from the oxazolidinones by treatment with aqueous base. We have synthesized a variety of substituted bicyclic aziridine precursors from the corresponding azidoformates using an intramolecular aziridination reaction. The nucleophilic ring opening of these bicyclic aziridines using carbon, oxygen, nitrogen, sulfur, and halogen-containing nucleophiles provided the oxazolidinones in good yield with high regioselectivity. In all cases, nucleophilic attack occurred exclusively at the least substituted carbon of the aziridine ring. Consequently, our approach allows for convenient and rapid access to the vicinal amino alcohol functionality, an important structural component of many natural products.
A simple, economical, and effective portable paediatric mock circulatory system (2011)

Ventricular assist devices (VADs) and total artificial hearts have been in development for the last 50 years. Since their inception, simulators of the circulation with different degrees of complexity have been produced to test these devices in vitro. Currently, a new path has been taken with the extensive efforts to develop paediatric VADs, which require totally different design constraints. This paper presents the manufacturing details of an economical simulator of the systemic paediatric circulation. This simulator allows the insertion of a paediatric VAD, includes a pumping ventricle, and is adjustable within the paediatric range. Rather than focusing on complexity and physiological simulation, this simulator is designed to be simple and practical for rapid device testing. The simulator was instrumented with medical sensors and data were acquired under different conditions with and without the new PediaFlowTM paediatric VAD. The VAD was run at different impeller speeds while simulator settings such as vascular resistance and stroke volume were varied. The hydraulic performance of the VAD under pulsatile conditions could be characterized and the magnetic suspension could be tested via manipulations such as cannula clamping. This compact mock loop has proven to be valuable throughout the PediaFlow development process and has the advantage that it is uncomplicated and can be manufactured cheaply. It can be produced by several research groups and the results of different VADs can then be compared easily.
Tungsten inverse opals: the influence of absorption on the photonic band structure in the visible spectral region (2004)

We fabricate and characterize tungsten inverse opals for the visible and near-infrared spectral region. The influence of absorption in this spectral region and the resulting breakdown of the bandstructure are experimentally investigated in detail.
Comparison of Extraperitoneal and Transperitoneal Robot-Assisted Radical Prostatectomy in Prostate Cancer: A Single Surgeon's Experience (2009)

PURPOSE: To evaluate the feasibility and safety of the extraperitoneal robotic radical prostatectomy (ERP), we compared the results of transperitoneal robotic radical prostatectomy (TRP) with those of ERP performed by a single surgeon. MATERIALS AND METHODS: All operation was performed by a single surgeon, who had the experience of more than 150 transperitoneal cases. Recently, 30 cases were performed through transperitoneal approach, and then extraperitoneal approach was applied to next 30 cases. We compared the clinicopathologic parameters and perioperative outcomes between two groups. RESULTS: There were no significant differences in mean age, body mass index (BMI), preoperative prostate-specific antigen (PSA) level, prostatectomy Gleason scores and pathologic T stage between two groups, whereas positive surgical margin rate was significantly lower in ERP. There was no significant difference in total operation time, whereas console time, and vesicourethral anastomosis time significantly decreased in ERP. There were no significant differences in postoperative normal diet start day, the duration of hospital stay and bladder catheterization. There were no significant differences in the amount of estimated blood loss and the number of resected lymph nodes. In both groups, there were no inadvertent organ injury during trocar placement and conversion to open surgery, whereas 1 case of lymphocele in ERP was recovered with conservative care. CONCLUSIONS: ERP showed similar perioperative outcomes compared to TRP. Considering the potential risk of bowel injury in TRP and reduced peritoneal irritation in ERP, ERP may be alternative in robotic radical prostatectomy
Speech Recognition with Augmented Synthesized Speech (2019)

Recent success of the Tacotron speech synthesis architecture and its variants in producing natural sounding multi-speaker synthesized speech has raised the exciting possibility of replacing expensive, manually transcribed, domain-specific, human speech that is used to train speech recognizers. The multi-speaker speech synthesis architecture can learn latent embedding spaces of prosody, speaker and style variations derived from input acoustic representations thereby allowing for manipulation of the synthesized speech. In this paper, we evaluate the feasibility of enhancing speech recognition performance using speech synthesis using two corpora from different domains. We explore algorithms to provide the necessary acoustic and lexical diversity needed for robust speech recognition. Finally, we demonstrate the feasibility of this approach as a data augmentation strategy for domain-transfer. We find that improvements to speech recognition performance is achievable by augmenting training data with synthesized material. However, there remains a substantial gap in performance between recognizers trained on human speech those trained on synthesized speech.
Limit Pricing and Entry Under Incomplete Information: An Equilibrium Analysis (1998)

Limit pricing involves charging prices below the monopoly price to make new entry appear unattractive.If the entrant is a rational decision maker with complete information, pre-entry prices will not influence its entry decision, so the established firm has no incentive to practice limit pricing.However, if the established firm has private, payoff relevant information (e.g., about costs), then prices can signal that information, so limit pricing can arise in equilibrium.The probability that entry actually occurs in such an equilibrium, however, can be lower, the same, or even higher than in a regime of complete information (where no limit pricing would occur).'Much of the work reported here first appeared in [11].This work has been presented at a large number of conferences, meetings, and seminars, and we would like to thank our audiences at each of these events for their comments.We are particularly indebted to Eric Maskin, Roger Myerson, Steve Salop, Robert Wilson, and two referees for their helpful suggestions, to David Besanko for his excellent research assistance,
Hematite-based Photo-oxidation of Water Using Transparent Distributed Current Collectors (2013)

High specific surface area transparent and conducting frameworks, fabricated by atomic layer deposition (ALD), were used as scaffolds for fabrication of equally high area, ALD-formed hematite structures for photo-oxidation of water to dioxygen. The frameworks offer high transparency to visible light and robust conductivity under harsh annealing and oxidizing conditions. Furthermore, they also make possible the spatially distributed collection of photocurrent from ultrathin coatings of hematite layers, enabling the formation of photoanodes featuring both large optical extinction and a hematite layer thickness nearly commensurate with the hole-collection distance. The distributed-current-collection approach increases the efficiency of water oxidation with hematite (by about a factor of 3 compared with an optimized flat electrode), is highly adaptable to future advances in thin film technology, and is further applicable to a multitude of nanostructures and optoelectronic applications that require ultrathin films without sacrificing optical thickness.
Infection of a brain abscess of Mycoplasma hominis (1981)

Persistent fever in a young man after evacuation of a subdural hematoma caused by a depressed skull fracture made it necessary to carry out a computerized tomographic exam of the head that demonstrated a left frontal lobe brain abscess. Mycoplasma hominis was recovered from this abscess as the sole infecting organism. Serial computerized tomographic scans showed resolution after aspiration and antibiotic therapy.
ChemInform Abstract: Synthesis and Structure of the Unligated Carbene of Chromium. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.