gebhart/patrepeval huggingface dataset:
Direct Extracellular Contact between Integrin α3β1 and TM4SF Protein CD151 (2000)

Previously we established that the alpha(3)beta(1) integrin shows stable, specific, and stoichiometric association with the TM4SF (tetraspannin) protein CD151. Here we used a membrane impermeable cross-linking agent to show a direct association between extracellular domains of alpha(3)beta(1) and CD151. The alpha(3)beta(1)-CD151 association site was then mapped using chimeric alpha(6)/alpha(3) integrins and CD151/NAG2 TM4SF proteins. Complex formation required an extracellular alpha(3) site (amino acids (aa) 570-705) not previously known to be involved in specific integrin contacts with other proteins and a region (aa 186-217) within the large extracellular loop of CD151. Notably, the anti-CD151 monoclonal antibody TS151r binding epitope, previously implicated in alpha(3) integrin association, was mapped to the same region of CD151 (aa 186-217). Finally, we demonstrated that both NH(2)- and COOH-terminal domains of CD151 are located on the inside of the plasma membrane, thus confirming a long suspected model of TM4SF protein topology.
ChemInform Abstract: Palladium‐Catalyzed Intermolecular Coupling of Aryl Halides and Amides. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Regulatory T Cells May Induce Tolerance Early in the Course of Tumor Development (2004)

s for the 19th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer, San Francisco, California, November 4-7, 2004: Mechanisms of Escape/Resistance
Engineering Resistance to Herbicides (2004)

Abstract Crop resistance can be generated through a selection process or the introduction of a gene via transformation. We will refer to the latter as engineered herbicide resistance. The literature contains numerous studies on engineered plant resistance to various herbicide classes. There is a large distinction between demonstrating a resistance phenotype in plants versus developing a commercial resistant crop that requires consistent performance under varying environmental conditions. Creating an herbicide resistant crop must successfully navigate a maze of key technical issues while satisfying the practical product goals of agronomic equivalence, weed management, economic feasibility, governmental regulatory compliance and public acceptance. Most of our experience has been derived from developing crop resistance to glyphosate. In this review, we will utilise these experiences to describe the essential studies required for the development of a commercial herbicide‐resistant crop with emphasis on the development of glyphosate resistance.
A survey on rare earth doped optical fiber amplifiers (2013)

The rare-earth-doped fiber amplifier (REDFA) has a significant role in the development of worldwide fiber-optic networks. This paper present a survey on the introduction to the history of the rare earth doped optical fiber amplifier as well as the context within which fiber amplifiers are having a very significant commercial impact along with its use as an amplifier. The most significant points in any optical amplifier design are gain and noise figure (NF), low NF and high gain are the main features for optimum REDFA. The emergence of the fiber amplifier indicates the invention and development of further guided wave devices that should play a major role in the continuing increase in transmission capacity and functionality of the fibers.
Substrate recognition by a sucrose transporting protein. (1986)

Protoplasts derived from developing soybean cotyledons were used to study substrate recognition by a sucrose transporting protein in plant membranes. When used as alternate substrate inhibitors of [14C] sucrose influx, five different fructosyl-substituted sucrose derivatives, phenyl-alpha-D-glucopyranoside, and phenyl-alpha-D-thioglucopyranoside proved to bind effectively to the sucrose carrier-active site. These results are interpreted to indicate that a large portion of substrate recognition by this carrier may arise from the interaction of a relatively hydrophobic portion of the sucrose molecule and a hydrophobic region of the carrier protein binding site. Binding of phenyl-alpha-D-thioglucopyranosides in which various substitutions were made for the glucosyl hydroxyls shows that the glucosyl hydroxyls at positions 3, 4, and 6 are involved in substrate recognition by the carrier protein.
Pharmacological inhibition of mannose-binding lectin ameliorates neurobehavioral dysfunction following experimental traumatic brain injury (2016)

Mannose-binding lectin is present in the contusion area of traumatic brain-injured patients and in that of traumatic brain-injured mice, where mannose-binding lectin-C exceeds mannose-binding lectin-A. The reduced susceptibility to traumatic brain injury of mannose-binding lectin double knock-out mice (mannose-binding lectin<sup>-/-</sup>) when compared to wild type mice suggests that mannose-binding lectin may be a therapeutic target following traumatic brain injury. Here, we evaluated the effects of a multivalent glycomimetic mannose-binding lectin ligand, Polyman9, following traumatic brain injury in mice. In vitro surface plasmon resonance assay indicated that Polyman9 dose-dependently inhibits the binding to immobilized mannose residues of plasma mannose-binding lectin-C selectively over that of mannose-binding lectin-A. Male C57Bl/6 mice underwent sham/controlled cortical impact traumatic brain injury and intravenous treatment with Polyman9/saline. Ex-vivo surface plasmon resonance studies confirmed that Polyman9 effectively reduces the binding of plasma mannose-binding lectin-C to immobilized mannose residues. In vivo studies up to four weeks post injury, showed that Polyman9 induces significant improvement in sensorimotor deficits (by neuroscore and beam walk), promotes neurogenesis (73% increase in doublecortin immunoreactivity), and astrogliosis (28% increase in glial fibrillary acid protein). Polyman9 administration in brain-injured mannose-binding lectin<sup>-/-</sup> mice had no effect on post-traumatic brain-injured functional deficits, suggestive of the specificity of its neuroprotective effects. The neurobehavioral efficacy of Polyman9 implicates mannose-binding lectin-C as a novel therapeutic target for traumatic brain injury.
Space Shuttle Crawler Transporter Sound Attenuation Study (2004)

The crawler transporter (CT) is the world's largest tracked vehicle known, weighing 6 million pounds with a length of 131 feet and a width of 113 feet. The Kennedy Space Center (KSC) has two CTs that were designed and built for the Apollo program in the 1960's, maintained and retrofitted for use in the Space Shuttle program. As a key element of the Space Shuttle ground systems, the crawler transports the entire 12-million-pound stack comprising the orbiter, the mobile launch platform (MLP), the external tank (ET), and the solid rocket boosters (SRB) from the Vehicle Assembly Building (VAB) to the launch pad. This rollout, constituting a 3.5-5.0-mile journey at a top speed of 0.9 miles-per-hour, requires over 8 hours to reach either Launch Complex 39A or B. This activity is only a prelude to the spectacle of sound and fury of the Space Shuttle launch to orbit in less than 10 minutes and traveling at orbital velocities of Mach 24. This paper summarizes preliminary results from the Crawler Transporter Sound Attenuation Study, encompassing test and engineering analysis of significant sound sources to measure and record full frequency spectrum and intensity of the various noise sources and to analyze the conditions of vibration. Additionally, data such as ventilation criteria, plus operational procedures were considered to provide a comprehensive noise suppression design for implementation. To date, sound attenuation study and results on Crawler 2 have shown significant noise reductions ranging from 5 to 24 dBA.
Asymmetric Hydrogenation of Seven‐Membered C=N‐containing Heterocycles and Rationalization of the Enantioselectivity (2016)

Iridium(I) complexes with phosphine-phosphite ligands efficiently catalyze the enantioselective hydrogenation of diverse seven-membered C=N-containing heterocyclic compounds (eleven examples; up to 97 % ee). The P-OP ligand L3, which incorporates an ortho-diphenyl substituted octahydrobinol phosphite fragment, provided the highest enantioselectivities in the hydrogenation of most of the heterocyclic compounds studied. The observed stereoselection was rationalized by means of DFT calculations.
Physical activity detection in patients with intracardiac leadless pacemaker (2018)

The three-axis accelerometer-based rate adaptive pacing feature proved to be feasible after manual selection of an adequate activity vector. Vector testing in Micra patients with chronotropic incompetence appears to be beneficial compared with the use of nominal Vector 1.
QUAREP-LiMi: a community endeavor to advance quality assessment and reproducibility in light microscopy (2021)

The community-driven initiative Quality Assessment and Reproducibility for Instruments & Images in Light Microscopy (QUAREP-LiMi) wants to improve reproducibility for light microscopy image data through quality control (QC) management of instruments and images. It aims for a common set of QC guidelines for hardware calibration and image acquisition, management and analysis.
Delayed and stage specific phosphorylation of H2AX during preimplantation development of γ-irradiated mouse embryos (2007)

Within minutes of the induction of DNA double-strand breaks in somatic cells, histone H2AX becomes phosphorylated in the serine 139 residue at the damage site. The phosphorylated H2AX, designated as gamma-H2AX, is visible as nuclear foci in the irradiated cells which are thought to serve as a platform for the assembly of proteins involved in checkpoint response and DNA repair. It is known that early stage mammalian embryos are highly sensitive to radiation but the mechanism of radiosensitivity is not well understood. Thus, we investigated the damage response of the preimplantation stage development by analyzing focus formation of gamma-H2AX in mouse embryos gamma-irradiated in utero. Our analysis revealed that although H2AX is present in early preimplantation embryos, its phosphorylation after 3 Gy gamma-irradiation is hindered up to the two cell stage of development. When left in utero for another 24-64 h, however, these irradiated embryos showed delayed phosphorylation of H2AX. In contrast, phosphorylation of H2AX was readily induced by radiation in post-compaction stage embryos. It is possible that phosphorylation of H2AX is inefficient in early stage embryos. It is also possible that the phosphorylated H2AX exists in the dispersed chromatin structure of early stage embryonic pronuclei, so that it cannot readily be detected by conventional immunostaining method. In either case, this phenomenon is likely to correlate with the lack of cell cycle arrest, apoptosis and high radiosensitivity of these developmental stages.
Taking anti-neutrophil cytoplasmic antibody (ANCA) testing beyond the limits (2002)

The application of anti-neutrophil cytoplasmic antibody (ANCA) testing has received much interest since ANCA were discovered [1] and since they were reported to be useful in both the diagnosis and monitoring of disease activity in Wegener’s granulomatosis (WG) [2]. Although there is little doubt that the recognition of the association between the presence of ANCA and active vasculitis has had a very positive influence on research on the pathogenesis and treatment of ANCA-associated diseases (reviewed by Savage [3]), there are reasons to worry about the application of this recently gained knowledge in clinical practice. In this comment the problems with the clinical application of ANCA tests are categorized for the sake of clarity as (i) standardization problems, (ii) difficulties with application of the test in the appropriate clinical context and (iii) the assumption that ANCA titres alone are reliable and sufficient to monitor disease activity and therapy during follow-up of patients.
Phase‐Engineered PtSe2‐Layered Films by a Plasma‐Assisted Selenization Process toward All PtSe2‐Based Field Effect Transistor to Highly Sensitive, Flexible, and Wide‐Spectrum Photoresponse Photodetectors (2018)

The formation of PtSe<sub>2</sub> -layered films is reported in a large area by the direct plasma-assisted selenization of Pt films at a low temperature, where temperatures, as low as 100 °C at the applied plasma power of 400 W can be achieved. As the thickness of the Pt film exceeds 5 nm, the PtSe<sub>2</sub> -layered film (five monolayers) exhibits a metallic behavior. A clear p-type semiconducting behavior of the PtSe<sub>2</sub> -layered film (≈trilayers) is observed with the average field effective mobility of 0.7 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> from back-gated transistor measurements as the thickness of the Pt film reaches below 2.5 nm. A full PtSe<sub>2</sub> field effect transistor is demonstrated where the thinner PtSe<sub>2</sub> , exhibiting a semiconducting behavior, is used as the channel material, and the thicker PtSe<sub>2</sub> , exhibiting a metallic behavior, is used as an electrode, yielding an ohmic contact. Furthermore, photodetectors using a few PtSe<sub>2</sub> -layered films as an adsorption layer synthesized at the low temperature on a flexible substrate exhibit a wide range of absorption and photoresponse with the highest photocurrent of 9 µA under the laser wavelength of 408 nm. In addition, the device can maintain a high photoresponse under a large bending stress and 1000 bending cycles.
Study on the Appropriate Measurement Spacing for EMF Installation Compliance Assessments of a 3.5 GHz 5G Base Station (2021)

The number of fifth generation (5G) base stations (BSs) installed for commercial services continues to increase in South Korea since the first 5G rollout of the 3.5 GHz band in 2019. However, this will cause a rapid increase in the cost and effort required for an electromagnetic field (EMF) installation compliance measurements of a 5G BS. This paper studies an appropriate measurement spacing for EMF installation compliance assessments of a 3.5 GHz 5G BS. Ray-tracing simulations based on the ray frustum technique are performed for three installation scenarios according to the accessibility categories provided in the International Telecommunication Union-T K.52 recommendation to observe the power density exposure trends. An interference analysis using the two-ray propagation model indicates that the spacing of 1 m can be suitable for the installation compliance of a 5G BS above 3 GHz. In addition, it was found that this spacing could be also applied up to the higher frequency of 7.125 GHz, the upper limit of Frequency Range 1 defined in the 3rd Generation Partnership Project specification. Measurements based on two different 5G signal extrapolations using the Synchronization Signal Block were conducted to validate the spacing of 1 m for a 3.5 GHz 5G BS established by simulation studies.
Pelotomaculum propionicicum sp. nov., an anaerobic, mesophilic, obligately syntrophic, propionate-oxidizing bacterium (2007)

An anaerobic, mesophilic, syntrophic, propionate-oxidizing bacterium, strain MGP(T), was isolated as a defined co-culture with Methanospirillum hungatei from the methanogenic sludge of a mesophilic upflow anaerobic sludge blanket (UASB) reactor. The strain grew in the presence of propionate, but only in co-culture with methanogens, suggesting that it is an obligately syntrophic bacterium. The optimum temperature for growth was 37 degrees C, and the optimum pH was between 6.5 and 7.2. Based on comparative 16S rRNA gene sequence analysis, strain MGP(T) was affiliated with subcluster Ih of 'Desulfotomaculum cluster I', in which it was found to be moderately related to known species of the genera Pelotomaculum and Cryptanaerobacter. Similar to known species of the genus Pelotomaculum, strain MGP(T) could degrade propionate in syntrophy, but had no ability to reduce sulfate, sulfite and thiosulfate. Further phenotypic and genetic studies supported the affiliation of the strain as a novel species in this genus, for which the name Pelotomaculum propionicicum sp. nov. is proposed. The type strain is MGP(T) (=DSM 15578(T)=JCM 11929(T)). The strain has been deposited in the DSM and JCM culture collections as a defined co-culture with Methanospirillum hungatei.
En Route to Structural Analogues of Epibatidine: A New Approach Towards 2-Pyridyl-7-oxabicyclo[2.2.1]heptanes (1996)

The synthesis of 2-pyridyl-7-oxabicyclo[2.2.1]heptanes 12, 13, 15 and 16 was accomplished via zinc chloride-mediated Diels-Alder reaction of furan 5 with 2- and 4-vinylpyridine 11 and 14 respectively. 12 and 13 can alternatively be prepared in near quantitative yield by photochemical cyclocotrimerization of nitriles 9 and 10 with acetylene.
WebFlowAH (2009)

This paper presents WebFlowAH, an environment for ad-hoc specifying and executing Web services-based business processes. WebFlowAH employs common domain ontology to describe both Web services and business processes. It allows specifying processes in terms of users' goals or desires that are expressed based on the concepts of such common domain ontology. This approach allows processes to be specified in an abstract high-level way, unburdening the user from dealing with underlying details needed to effectively run the process workflow.
Searching for solar KDAR with DUNE (2021)

The observation of 236 MeV muon neutrinos from kaon-decay-at-rest (KDAR)&#13;\noriginating in the core of the Sun would provide a unique signature of dark matter annihilation. Since excellent angle and energy reconstruction are necessary to detect this monoenergetic, directional neutrino flux, DUNE with its vast volume and reconstruction capabilities,&#13;\nis a promising candidate for a KDAR neutrino search. In this work, we evaluate the proposed&#13;\nKDAR neutrino search strategies by realistically modeling both neutrino-nucleus interactions&#13;\nand the response of DUNE. We find that, although reconstruction of the neutrino energy and&#13;\ndirection is difficult with current techniques in the relevant energy range, the superb energy&#13;\nresolution, angular resolution, and particle identification offered by DUNE can still permit&#13;\ngreat signal/background discrimination. Moreover, there are non-standard scenarios in which&#13;\nsearches at DUNE for KDAR in the Sun can probe dark matter interactions.
Recent Advances in Functional Materials through Cellulose Nanofiber Templating (2021)

Advanced templating techniques have enabled delicate control of both nano- and microscale structures and have helped thrust functional materials into the forefront of society. Cellulose nanomaterials are derived from natural polymers and show promise as a templating source for advanced materials. Use of cellulose nanomaterials in templating combines nanoscale property control with sustainability, an attribute often lacking in other templating techniques. Use of cellulose nanofibers for templating has shown great promise in recent years, but previous reviews on cellulose nanomaterial templating techniques have not provided extensive analysis of cellulose nanofiber templating. Cellulose nanofibers display several unique properties, including mechanical strength, porosity, high water retention, high surface functionality, and an entangled fibrous network, all of which can dictate distinctive aspects in the final templated materials. Many applications exploit the unique aspects of templating with cellulose nanofibers that help control the final properties of the material, including, but not limited to, applications in catalysis, batteries, supercapacitors, electrodes, building materials, biomaterials, and membranes. A detailed analysis on the use of cellulose nanofibers templating is provided, addressing specifically how careful selection of templating mechanisms and methodologies, combined toward goal applications, can be used to directly benefit chosen applications in advanced functional materials.
A cell surface antigen of the mouse related to xenotropic MuLv defined by naturally occurring antibody and monoclonal antibody. Relation to Gix G(rada1), G(aksl2) systems of MuLV-related antigens. (1981)

A new cell surface antigen of the mouse related to xenotropic murine leukemia virus (MuLV) is described. The antigen, designated G(erld), is defined by cytotoxic tests with the B6-x-ray-induced ERLD and naturally occurring antibody. G(erld) is distinct from all previously defined cell surface antigens. Monoclonal antibody with the same specificity has been developed. Inbred mouse strains are classified as G(erld)+ or G(erld)- according to the presence of absence of the antigen on lymphoid cells. G(erld)+ strains differ with regard to quantitative expression of G(erld) on normal thymocytes. The emergence of G(erld)+ tumors in G(erld)- strains indicates the presence of genes coding for the antigen even in strains not normally expressing the antigen. G(erld) has the characteristic of a differentiation antigen in normal mice. In G(erld)+ strains, high levels of the antigen are found on thymocytes with lower levels being detected on cells of spleen, lymph nodes and bone marrow. No G(erld) was detected in brain or kidney or on erythrocytes. The segregation ratios for G(erld) expression on thymocytes in backcross and F2 mice of crosses between G(erld)+ (B6, 129, and B6-Gix+) and G(erld)- (BALB/c) strains suggest that G(erld) expression is controlled by a single locus in B6, by two unlinked loci in 129, and by three unlinked loci in B6-Gix+ mice. Induction of the antigen by MuLV infection of permissive cells in vitro indicates that G(erld) is closely related to xenotropic and dualtropic MuLV; all xenotropic and dualtropic MuLV tested induced the antigen, whereas the majority of ecotropic and the two amphotropic MuLV failed to do so. As dualtropic MuLV are thought to be recombinants between ecotropic and xenotropic MuLV sequences, G(erld) coding by dualtropic MuLV may signify the contribution of the xenotropic part in the recombinational event. Serological and biochemical characterization indicates that G(erld) is related to the gp 70 component of the MuLV envelope. The relation of G(erld) to the previously defined gp 70-related cell surface antigens (Gix, G(rada), and G(aksl2) is discussed, particularly with regard to their characteristics as differentiation antigens, the genetic origin of dualtropic MuLV, and the leukemogenicity of MuLV.
Adaptive CAC in Satellite Communication Systems Using Fade Mitigation Techniques: An Overview (2007)

International audience
Use of coherence in activation detection during ventricular fibrillation (2003)

The use of cardiac activation mapping to study ventricular fibrillation (VF) is discussed. The locations of isochrones in maps are based on decisions on whether and when segments of the electrogram have local electrical activation. The authors compare two quantitative criteria for making decisions about local activity in electrograms. The criteria are based on the comparison of electrograms recorded in those excitable zones with electrograms recorded in normal myocardium. One uses the first derivative of the electrogram (only one electrogram affects the decision); the second uses the first derivative of the primarily local component of the waveform.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>