gebhart/patrepeval huggingface dataset:
Efficient assembly for complex objects (1991)

Although obJect-oriented database systems offer advantages over relational or record-oriented database systems, such as modelmg facll]tles for complex objects, they are cnticlzed for poor performance and query capabilities on set-oriented applications The unacceptable performance IS due m part to the ob]ect-at-a-time processing typically used by object-oriented database systems. We believe that improved performance of ob]ectoriented database systems depends partially on the efficient and se[ectxve retrveval of sets of complex objects from secondary storage. In this report, we present the method of complex object retrlevai and assembly used in the Volcano query processing system and the Revelation project. We also present experimental results comparing set-oriented versus obJect-at-a-t]me complex object assembly
Demonstration of ultra-fast IP restoration using reconfigurable transport networks (2003)

We integrate IP, data-link and transport capabilities for ultra-fast IP interface and link provisioning, and demonstrate two IP restoration schemes that use re-configurable transport networks: 1:N router interface protection and dynamic establishment of a new link upon failure.
Noncovalent Binding of a Reaction Intermediate by a Designed Helix‐Loop‐Helix Motif—Implications for Catalyst Design (2003)

In our search for a catalyst for the transamination reaction of aspartic acid to form oxaloacetate, twenty-five forty-two-residue sequences were designed to fold into helix-loop-helix dimers and form binding sites for the key intermediate along the reaction pathway, the aldimine. This intermediate is formed from aspartic acid and the cofactor pyridoxal phosphate. The design of the binding sites followed a strategy in which exclusively noncovalent forces were used for binding the aldimine. Histidine residues were incorporated to catalyse the rate-limiting 1,3 proton transfer reaction that converts the aldimine into the ketimine, an intermediate that is subsequently hydrolysed to form oxaloacetate and pyridoxamine phosphate. The two most efficient catalysts, T-4 and T-16, selected from the pool of sequences by a simple screening procedure, were shown by CD and NMR spectroscopies to bind the aldimine intermediate with dissociation constants in the millimolar range. The mean residue ellipticity of T-4 in aqueous solution at pH 7.4 and a concentration of 0.75 mM was -18500 deg x cm(2) dmol(-1). Upon addition of 6 mm l-aspartic acid and 1.5 mM pyridoxal phosphate to form the aldimine, the mean residue ellipticity changed to -19900 deg x cm(2) dmol(-1). The corresponding mean residue ellipticities of T-16 were -21200 deg x cm(2) dmol(-1) and -24000 deg x cm(2) dmol(-1). These results show that the helical content increased in the presence of the aldimine, and that the folded polypeptides bound the aldimine. The (1)H NMR relaxation time of the imine CH proton of the aldimine was affected by the presence of T-4 as was the (31)P NMR resonance linewidth. The catalytic efficiencies of T-4 and T-16 were compared to that of imidazole and found to be more than three orders of magnitude larger. The designed binding sites were thus shown to be capable of binding the aldimine in close proximity to His residues, by noncovalent forces, into conformations that proved to be catalytically active. The results show for the first time the design of well-defined catalytic sites that bind a reaction intermediate with enzyme-like affinities under equilibrium conditions and represent an important advance in de novo catalyst design.
Self-Assembled Borophene/Graphene Nanoribbon Mixed-Dimensional Heterostructures (2021)

Atomically thin metal-semiconductor heterojunctions are highly desirable for nanoelectronic applications. However, coherent lateral stitching of distinct two-dimensional (2D) materials has traditionally required interfacial lattice matching and compatible growth conditions, which remains challenging for most systems. On the other hand, these constraints are relaxed in 2D/1D mixed-dimensional lateral heterostructures due to the increased structural degree of freedom. Here, we report the self-assembly of mixed-dimensional lateral heterostructures consisting of 2D metallic borophene and 1D semiconducting armchair-oriented graphene nanoribbons (aGNRs). With the sequential ultrahigh vacuum deposition of boron and 4,4″-dibromo-<i>p</i>-terphenyl as precursors on Ag(111) substrates, an on-surface polymerization process is systematically studied and refined including the transition from monomers to organometallic intermediates and finally demetallization that results in borophene/aGNR lateral heterostructures. High-resolution scanning tunneling microscopy and spectroscopy resolve the structurally and electronically abrupt interfaces in borophene/aGNR heterojunctions, thus providing insight that will inform ongoing efforts in pursuit of atomically precise nanoelectronics.
Parcellation‐based anatomic model of the semantic network (2021)

We describe a preliminary cortical model for the underlying structural connectivity of the semantic network. Future studies will further characterize the neurotractographic details of the semantic network in the context of medical application.
Combinatorial computational picomolar ligands for a knov (2016)

Combinatorial small molecule growth algorithm was used to Bc design inhibitors for human carbonic anhydrase II. Two enanpr tiomeric candidate molecules were predicted to bind with high de potency (with R isomer binding stronger than S), but in two cu distinct conformations. The experiments verified that computath tional predictions concerning the binding affinities and the m binding modes were correct for both isomers. The designed R te isomer is the best-known inhibitor (Kd 30 pM) of human carbonic anhydrase II. fr( fu
A simple method for studying chemotaxis using sustained release of attractants from inert polymers (1980)

Chemotaxis of the bacterium Escherichia coli and the planarian Dugesia dorotocephala toward a variety of substances impregnated in sustained-release polymers has been demonstrated. Tests were carried out in soft agar and in aqueous medium with highly consistent results. The simplicity of this method may make it particularly useful for rapid qualitative screening of new wild-type and mutant strains of bacteria for chemotaxis toward nonmetabolites. The cost, ease of fabrication, and the facility with which they can be utilized in test systems suggest that these sustained-release vehicles will provide a new and general method of creating concentration gradients to study chemotaxis.
Experimental investigation of unique plasma jets for use as ion thrusters (1998)

Recent experimental results suggest the possible use of an Inertial-Electrostatic Confinement (EC) device as a low-power, high specific impulse satellite thruster. An EC device, when operating in what has been coined mode, produces a unique plasma jet that could be used as a highly efficient source of 5keV mono-energetic ions. If operated with heavy, noble gases this device could provide efficient, high specific impulse. This paper describes the results of the initial characterization studies of the EC in Halo mode. A series of experiments was conducted on an EC device with a 30-cm diameter vacuum vessel, and a 6.4-cm diameter cathode-grid with a 1.9-cm hole constructed on one side. Consistent, stable operation was observed for both argon and hydrogen gas over a wide range of pressures and voltages, producing a single jet out of the enlarged hole. A number of voltage vs. current curves were made for a bias post that was placed in the path of the plasma jet. Analysis concludes that the plasma jet has a sufficient electron population suitable for generating a substantial ion jet.
Ultra Wideband Light Source Using 136-Wavelengths SSB Frequency Sweep Technique for Optical Coherence Tomography (2007)

We demonstrate an ultra-wideband light source using multi-wavelength single-sideband modulation (SSB) frequency sweep technique, aiming at optical coherence tomography (OCT). The light source consists of an optical SSB frequency sweeper with an optical frequency comb generator cascaded with a multi-wavelength laser. Ultra-wideband signal was generated by sweeping frequency of each components of an optical multi-wavelength light source. The proposed system can achieve much faster and more precise spectrum measurement than the conventional OCT system.
NOX1 inhibition blocks endothelial cell migration and tube-like structure formation. (2015)

&lt;p&gt;In vitro migration was analyzed by wound-healing assay on mouse primary endothelial cells (a), human primary endothelial cells (b) and endothelioma cell lines (c). Tubular structure formation was measured by 3D culture of mouse primary endothelial cells (d), human primary endothelial cells (e) or endothelioma cell lines (f). Results are expressed in % of control ± s.e.m, n = 3. *p&lt;0.05, **p&lt;0.01, ***&lt;0.001 using Student's t-test. GKT136901 was used at 10 µM.&lt;/p&gt;
Water as an Inhibitor of Metal Corrosion in Hydrophobic Ionic Liquids (2012)

Water traces in hydrophobic ionic liquids surprisingly proved to exhibit unusual corrosion inhibiting behavior by protecting metal copper and nickel from electrochemical corrosion under aerobic conditions. The anodic dissolution of a copper electrode results in the formation of Cu (I) species. The simultaneous re-electrodeposition of nanocrystalline copper on the cathode occurred without additives to the resulting electrolyte.
Figure S3 from Inhibiting ERK5 Overcomes Breast Cancer Resistance to Anti-HER2 Therapy By Targeting the G<sub>1</sub>–S Cell-Cycle Transition (2023)

&lt;p&gt;Lapatinib treatment inhibits tyrosine phosphorylation of HER1/2/3 in both sensitive and resistant breast cancer cells.&lt;/p&gt;
Synthesis of 2‘,3‘-Dideoxyribonucleoside-3‘-N-(2-oxo-1,3,2-oxathiaphospholanes) and Their Reactions with 5‘-OH Nucleosides and Fluoride Ion (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSynthesis of 2',3'-Dideoxyribonucleoside-3'-N-(2-oxo-1,3,2-oxathiaphospholanes) and Their Reactions with 5'-OH Nucleosides and Fluoride IonJanina Baraniak, Dariusz Korczyñski, and Wojciech J. StecView Author Information Polish Academy of Sciences, Centre of Molecular and Macromolecular Studies, Department of Bioorganic Chemistry, Sienkiewicza 112, 90-363 L-ódź, Poland Cite this: J. Org. Chem. 1999, 64, 12, 4533–4536Publication Date (Web):May 18, 1999Publication History Received10 November 1998Published online18 May 1999Published inissue 1 June 1999https://pubs.acs.org/doi/10.1021/jo982240rhttps://doi.org/10.1021/jo982240rbrief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views260Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anions,Condensation,Genetics,Molecular structure,Solvents Get e-Alerts
Non-uniform array design for robust LoS MIMO via convex optimization (2023)

The array design problem of multiple-input multiple-output (MIMO) systems in a line-of-sight (LoS) transmit environment is examined. As uniform array configurations at the transmitter (Tx) and receiver (Rx) are optimal at specific transmit distances only, they lead to reduced spectral efficiency over a range of transmit distances. To that end, the joint design of nonuniform Tx and Rx arrays towards maximizing the minimum capacity of a LoS MIMO system across a range of transmit distances is investigated in this paper. By introducing convex relaxation, the joint Tx and Rx array design is cast as a convex optimization problem, which is solved in a iterative manner. In addition, we also implement a local search to obtain a refined solution that achieves an improved performance. It is shown that the non-uniform configurations designed with our proposed approach outperform uniform and non-uniform array designs of the literature in terms of capacity and/or complexity.
Short seeking by multirate digital controllers for computation saving with initial value adjustment (2006)

Multirate control has been proposed to reduce the real-time computation in hard disk drive (HDD) servo systems. It has been showed that computation can be saved greatly without performance degradation by using a multirate controller for track following. This paper proposes a novel method for short seeking control based on multirate track following control and initial value adjustment. This method, which uses the same multirate controller and the same servo structure as track following, adjusts the initial values of the track following controller for short seeking. Real-time computation is greatly saved in two aspects: 1) computation is saved by multirate scheme, and 2) initial value adjustment of the feedback controller makes the use of the feed-forward controller and reference trajectory unnecessary. Simulation and experimental results verify the effectiveness of the proposed method.
Multi-User Detection Using ADMM-Based Compressive Sensing for Uplink Grant-Free NOMA (2017)

Non-orthogonal multiple access (NOMA) is considered a primary candidate addressing the challenge of massive connectivity in fifth generation wireless communication systems. In this letter, we propose a low-complexity NOMA mechanism with efficient multi-user detection (MUD) based on the adaptive alternating direction method of multipliers, which is able to jointly detect user activity and transmitted data. The proposed algorithm leverages the transmit symbol estimate and active user set as “prior knowledge,” which can be obtained from the previous iterations/time intervals, for improved MUD performance. We demonstrate that our proposed mechanism outperforms the state-of-art MUD NOMA schemes.
Cutting Edge: GPR35/CXCR8 Is the Receptor of the Mucosal Chemokine CXCL17 (2014)

Chemokines are chemotactic cytokines that direct the traffic of leukocytes and other cells in the body. Chemokines bind to G protein-coupled receptors expressed on target cells to initiate signaling cascades and induce chemotaxis. Although the cognate receptors of most chemokines have been identified, the receptor for the mucosal chemokine CXCL17 is undefined. In this article, we show that GPR35 is the receptor of CXCL17. GPR35 is expressed in mucosal tissues, in CXCL17-responsive monocytes, and in the THP-1 monocytoid cell line. Transfection of GPR35 into Ba/F3 cells rendered them responsive to CXCL17, as measured by calcium-mobilization assays. Furthermore, GPR35 expression is downregulated in the lungs of Cxcl17(-/-) mice, which exhibit defects in macrophage recruitment to the lungs. We conclude that GPR35 is a novel chemokine receptor and suggest that it should be named CXCR8.
New Insulating Materials for Next Generation of HVDC Cables - Methods for Evaluation of Degradation Phenomena by Electrical Treeing (2013)

The ongoing in Sweden research activities aim to\nelaborate new material concepts that can be\napplicable in designing and manufacturing high\nvoltage direct current (HVDC) cables for very high\nvoltage levels, up to 800 kV. This task focuses on\ninvestigating possibilities provided by use of\nmaterials containing nanofillers and voltage\nstabilizers. Variations in breakdown strength,\nelectrical conductivity and control of space charges\nwith temperature and composition as well as their\nstability during long-term operation are investigated.\nThis paper describes a part of the work that\nconcentrates on elaborating a robust methodology\nfor testing material resistance to electrical tree\ninception. It is argued that AC treeing test under\nramped voltage may effectively be used for\nscreening candidate materials for applications in\nHVDC cable insulation.
Towards Cohesive Extractive Summarization through Anaphoric Expression Resolution (2016)

This paper presents a new method for improving the cohesiveness of summaries generated by extractive summarization systems. The solution presented attempts to improve the legibility and cohesion of the generated summaries through coreference resolution. It is based on a post-processing step that binds dangling coreference to the most important entity in a given coreference chain. The proposed solution was evaluated on the CNN corpus of 3,000 news articles, using four state-of-the-art summarization systems and seventeen techniques for sentence scoring proposed in the literature. The experimental results may be considered encouraging, as the final summaries reached better ROUGE scores, besides being more cohesive.
Extended cross-component prediction in HEVC (2017)

With Version 2 of the high-efficiency video coding standard, a new compression efficiency tool targeting redundancies among color components is specified for all 4:4:4 profiles, and referred to as cross-component prediction (CCP). This paper describes and analyses two additional extensions to the specified CCP variant. In the first extension, an additional predictor is introduced. Particularly, beside the luma component, also the first chroma component can serve as a reference for prediction of the second chroma component. The second extension proposes a method for predicting the CCP model parameter from the statistics of already reconstructed neighboring blocks. A performance analysis of coding RGB content in different color representations is given in comparison with CCP and both extensions. Experimental results show that the proposed extensions can improve the compression efficiency effectively compared with CCP, when applied in the YC b C r domain.
Fixational stability as a measure for the recovery of visual function in amblyopia (2021)

People with amblyopia have been shown to have decreased fixational stability, particularly those with strabismic amblyopia. Fixational stability and visual acuity have been shown to be tightly correlated across multiple studies, suggesting a relationship between acuity and oculomotor stability. Reduced visual acuity is the sine qua non of amblyopia, and recovery is measured by the improvement in visual acuity. Here we ask whether fixational stability can be used as an objective marker for the recovery of visual function in amblyopia. We tracked children's fixational stability during patching treatment over time and found fixational stability changes alongside improvements in visual acuity. This suggests fixational stability can be used as an objective measure for monitoring treatment in amblyopia and other disorders.
The Musician Redefined: A Behavioral Assessment of Rhythm Perception in Professional Club DJs (2015)

Studies of musical training demonstrate functional advantages in rhythm tasks that result from enriched auditory experience. Anatomical correlates exist in brain areas involved in auditory perception, speech processing, motor control, attention, and emotion. However, these studies fail to include many classes of musicians that might undergo experience-related change. The current study examined rhythm processing in professional disc jockeys (DJs) who routinely engage in temporally-demanding tasks during practice and performance. In Experiment 1, DJs outperformed controls at detecting a deviation in a rhythmic pattern, and were no different than trained percussionists. In Experiment 2, participants receiving one week of DJ training trended toward outperforming untrained participants on this same measure. Across experiments, movement improved detection of rhythmic deviations, providing evidence of privileged auditory-motor connections, and underscoring the importance of motor areas to rhythm perception. It is clear that DJs show experience-dependent changes in perception that are comparable to more traditional musicians.
miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors (2011)

Postnatal heart stem and progenitor cells are a potential therapeutic tool for cardiomyopathies, but little is known about the mechanisms that control cardiac differentiation. Recent work has highlighted an important role for microribonucleic acids (miRNAs) as regulators of cardiac and skeletal myogenesis. In this paper, we isolated cardiac progenitors from neonatal β-sarcoglycan (Sgcb)-null mouse hearts affected by dilated cardiomyopathy. Unexpectedly, Sgcb-null cardiac progenitors spontaneously differentiated into skeletal muscle fibers both in vitro and when transplanted into regenerating muscles or infarcted hearts. Differentiation potential correlated with the absence of expression of a novel miRNA, miR669q, and with down-regulation of miR669a. Other miRNAs are known to promote myogenesis, but only miR669a and miR669q act upstream of myogenic regulatory factors to prevent myogenesis by directly targeting the MyoD 3' untranslated region. This finding reveals an added level of complexity in the mechanism of the fate choice of mesoderm progenitors and suggests that using endogenous cardiac stem cells therapeutically will require specially tailored procedures for certain genetic diseases.
Effect of Empagliflozin on Cardiovascular and Renal Outcomes in Patients With Heart Failure by Baseline Diabetes Status (2020)

In EMPEROR-Reduced (Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Reduced Ejection Fraction), empagliflozin significantly improved cardiovascular and renal outcomes in patients with heart failure and a reduced ejection fraction, independent of baseline diabetes status and across the continuum of HbA1c. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03057977.
Feedback-driven dynamic invariant discovery (2014)

Program invariants can help software developers identify program properties that must be preserved as the software evolves, however, formulating correct invariants can be challenging. In this work, we introduce iDiscovery, a technique which leverages symbolic execution to improve the quality of dynamically discovered invariants computed by Daikon. Candidate invariants generated by Daikon are synthesized into assertions and instrumented onto the program. The instrumented code is executed symbolically to generate new test cases that are fed back to Daikon to help further refine the set of candidate invariants. This feedback loop is executed until a fix-point is reached. To mitigate the cost of symbolic execution, we present optimizations to prune the symbolic state space and to reduce the complexity of the generated path conditions. We also leverage recent advances in constraint solution reuse techniques to avoid computing results for the same constraints across iterations. Experimental results show that iDiscovery converges to a set of higher quality invariants compared to the initial set of candidate invariants in a small number of iterations.