gebhart/patrepeval huggingface dataset:
Low-noise short-wavelength pumped frequency down-conversion for Quantum Frequency Converters (2023)

In this paper, we present a novel single stage quantum frequency conversion (QFC) scheme based on an enhancement cavity, which allows for high conversion efficiencies with record low noise levels, 100 times smaller than in previous systems and close to the thermal background. Our approach represents a significant improvement over traditional QFC methods that rely on periodically poled waveguide crystals, which typically produce high levels of noise with input wavelengths in the visible spectrum. One of the key challenges in QFC is the generation of noise photons - photons that are not part of the desired output state. Those noise photons are one of the major limitations of today’s quantum network experiments. It has been widely believed that single stage QFC of qubit photons in the visible range would result in too many noise photons in the telecom band, because of SPDC induced by the short wavelength driver laser. However, using the enhancement cavity design, we are able to overcome this challenge and demonstrate high-fidelity QFC from the visible to telecom band. Our results have important implications for the development of practical QFC devices for a range of applications, including quantum communication and quantum networks, where low noise levels are critical.
Using capillary electrophoresis to study methylation effect on RNA-peptide interaction. (2003)

Methylation of RNA and proteins is one of a broad spectrum of post-transcriptional/translational mechanisms of gene expression regulation. Its functional signification is only beginning to be understood. A sensitive capillary electrophoresis mobility shift assay (CEMSA) for qualitative study of the methylation effect on biomolecules interaction is presented. Two RNA-peptide systems were chosen for the study. The first one consists of a 17-nucleotide analogue (+27-+43) of the yeast tRNA(Phe) anticodon stem and loop domain (ASL(Phe)) containing three of the five naturally occurring modifications (2'-O-methylcytidine (Cm(32)), 2'-O-methylguanine (Gm(34)) and 5-methylcytidine (m(5)C(40))) (ASL(Phe)-Cm(32),Gm(34),m(5)C(40)) and a 15-amino-acid peptide (named t(F)2: Ser(1)-Ile-Ser-Pro-Trp(5)-Gly-Phe-Ser-Gly-Leu(10)-Leu- Arg-Trp-Ser-Tyr(15)) selected from a random phage display library (RPL). A peptide-concentration-dependent formation of an RNA-peptide complex was clearly observable by CEMSA. In the presence of the peptide the capillary electrophoresis (CE) peak for triply methylated ASL(Phe) shifted from 18.16 to 20.90 min. Formation of the complex was not observed when an unmethylated version of ASL(Phe) was used. The second system studied consisted of the (+18)-(+44) fragment of the trans-activation response element of human immunodeficiency virus type 1 (TAR RNA HIV-1) and a 9-amino-acid peptide of the trans-activator of transcription protein (Tat HIV-1) Tat(49-57)-NH(2) (named Tat1: Arg(49)-Lys-Lys-Arg(52)-Arg-Gln-Arg-Arg- Arg(57)-NH(2)). In the presence of Tat(49-57)-NH(2) a significant shift of migration time of TAR from 18.66 min to 20.12 min was observed. Methylation of a residue Arg(52)-->Arg(Me)(2), crucial for TAR binding, strongly disrupted formation of the complex. Only at a high micromolar peptide concentration a poorly shaped, broad peak of the complex was observed. CE was found to be an efficient and sensitive method for the analysis of methylation effects on interaction of biomolecules.
The extensional rheology of non-Newtonian materials (1994)

The evolution of the transient extensional stresses in dilute and semi-dilute viscoelastic polymer solutions are measured with a filament stretching rheometer of a design similar to that first introduced by Sridhar, et al. The solutions are polystyrene-based (PS) Boger fluids that are stretched at constant strain rates ranging from 0.6 less than or equal to epsilon(0) less than or equal to 4s(exp -1) and to Hencky strains of epsilon greater than 4. The test fluids all strain harden and Trouton ratios exceeding 1000 are obtained at high strains. The experimental data strain hardens at lower strain levels than predicted by bead-spring FENE models. In addition to measuring the transient tensile stress growth, we also monitor the decay of the tensile viscoelastic stress difference in the fluid column following cessation of uniaxial elongation as a function of the total imposed Hencky strain and the strain rate. The extensional stresses initially decay very rapidly upon cessation of uniaxial elongation followed by a slower viscoelastic relaxation, and deviate significantly from FENE relaxation predictions. The relaxation at long times t is greater than or equal to 5 s, is compromised by gravitational draining leading to non-uniform filament profiles. For the most elastic fluids, partial decohension of the fluid filament from the endplates of the rheometer is observed in tests conducted at high strain rates. This elastic instability is initiated near the rigid endplate fixtures of the device and it results in the progressive breakup of the fluid column into individual threads or 'fibrils' with a regular azimuthal spacing. These fibrils elongate and bifurcate as the fluid sample is elongated further. Flow visualization experiments using a modified stretching device show that the instability develops as a consequence of an axisymmetry-breaking meniscus instability in the nonhomogeneous region of highly deformed fluid near the rigid endplate.
Integrated state estimation and load modelling for distribution grids with ampere measurements (2013)

State estimation is essential for a smarter monitoring and control of distribution power networks, but need to rely largely on current magnitude measurements, which causes non-uniqueness of the solution. Constraining the problem based on prior knowledge of the sign of the injections, as previously proposed, requires more complex estimators, does not always ensure uniqueness and prevents anomaly detection in the case of wrong prior assumptions. By including also prior knowledge of the magnitudes of the injections, coming from statistical load modelling, we show how it is possible to resort to conventional state estimators while achieving an increased reliability of the solution as well as the ability to detect/correct wrong prior models, using classical bad data analysis.
Symptoms Related to the Menopause and Sex Steroid Treatments (2007)

In the menopause transition, ovarian steroid production is gradually inhibited and around 35% of women will seek medical help for postmenopausal symptoms. The hot flush is a characteristic manifestation occurring in about 70% of women; it is associated with oestrogen withdrawal and disappears with oestrogen-based hormone replacement therapy. The exact mechanism behind it is still unclear but is probably related to heat loss mechanisms. The flush often occurs in parallel to changes in skin temperature, blood flow, pulse rate and pulses of luteinizing hormone (LH). These are probably secondary to a disturbance in the thermoregulatory centre of the CNS, which is anatomically close to neurons containing gonadotropin-releasing hormone. Depression is no more frequent in the menopausal transition than at other times in life. After surgical menopause, however, oestrogen improves low mood over placebo. In women with premenstrual syndrome, an increased feeling of well-being is associated with the pre-ovulatory oestrogen peak. Progestogens are associated with negative mood changes during the menstrual cycle, oral contraception and postmenopausal replacement therapy. Certain progesterone metabolites are anaesthetic and have anti-epileptic and anxiolytic properties, effects which are mediated via the type A gamma-aminobutyric acid (GABAA) receptor. Oestrogen is associated with increased sensory perception, locomotory activity, limb coordination and balance: this may help explain the increased frequency of bone fractures in the early postmenopausal period. Oestrogen improves memory and performance in patients with mild Alzheimer's dementia and increases epileptic activity in patients with partial epilepsy. These effects can be related to amplifying effects of oestrogen on excitatory amino acids in the CNS.
Immunohistochemical study of Dlx1 and Msx1 expression during cephalic development of Dumbo and Wistar rats. Correlation with morphological data (2011)

The Dumbo rat is characterized by a short snout, low ears and relative hypoplasia of maxillar and zygomatic bones. It corresponds to an autosomal recessive genotype. Previous study demonstrated a global deficit of Dlx1 and Msx1 genes expression in comparison to Wistar embryos as considered as control animals. We performed a histological study of cephalic development of Dumbo rats compared to Wistar embryos and an immunohistochemical analysis of Dlx1 and Msx1 protein expression during cephalogenesis. Our data indicate that the pattern of expression of both genes is similar in both strains, but that quantitative differences in gene expression can be the result of delayed organogenesis in Dumbo rat in comparison to Wistar. Some data about gene expressions are discussed at the light of the postulated function of Dlx1 and Msx1 in cephalic development.
Data from <i>HOXB13</i> G84E Mutation in Finland: Population-Based Analysis of Prostate, Breast, and Colorectal Cancer Risk (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; A recently identified germline mutation G84E in &lt;i&gt;HOXB13&lt;/i&gt; was shown to increase the risk of prostate cancer. In a family-based analysis by The International Consortium for Prostate Cancer Genetics (ICPCG), the G84E mutation was most prevalent in families from the Nordic countries of Finland (22.4%) and Sweden (8.2%).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; To further investigate the importance of G84E in the Finns, we determined its frequency in more than 4,000 prostate cancer cases and 5,000 controls. In addition, 986 breast cancer and 442 colorectal cancer (CRC) cases were studied. Genotyping was conducted using TaqMan, MassARRAY iPLEX, and sequencing. Statistical analyses were conducted using Fisher exact test, and overall survival was analyzed using Cox modeling.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; The frequency of the G84E mutation was significantly higher among patients with prostate cancer and highest among patients with a family history of the disease, hereditary prostate cancer [8.4% vs. 1.0% in controls; OR 8.8; 95% confidence interval (CI), 4.9–15.7]. The mutation contributed significantly to younger age (≤55 years) at onset and high prostate-specific antigen (PSA; ≥20 ng/mL) at diagnosis. An association with increased prostate cancer risk in patients with prior benign prostate hyperplasia (BPH) diagnosis was also revealed. No statistically significant evidence for a contribution in CRC risk was detected, but a suggestive role for the mutation was observed in familial BRCA1/2-negative breast cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; These findings confirm an increased cancer risk associated with the G84E mutation in the Finnish population, particularly for early-onset prostate cancer and cases with substantially elevated PSA.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Impact:&lt;/b&gt; This study confirms the overall importance of the &lt;i&gt;HOXB13&lt;/i&gt; G84E mutation in prostate cancer susceptibility. &lt;i&gt;Cancer Epidemiol Biomarkers Prev; 22(3); 452–60. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
A system of systems framework: Cooperative Maneuvers Manager for Autonomous Vehicles (2018)

Systems of Systems (SoS) are complex systems, in which constituent systems are by themselves independent systems, that cooperate to achieve a common goal. Intelligent Transportation Systems (ITS) are SoS that seek to achieve better transportation experience for users, by using communication between different users of such systems. In this paper, we present the Cooperative Maneuvers Manager for Autonomous Vehicles (CMMAV), a SoS framework that contributes to the ITS by enabling autonomous vehicles to perform complex maneuvers on highways in a cooperative way. We used Systems of Systems Approach to Context-based Requirements Engineering (SoS-ACRE) to model the system.
Periodic Mesoporous Organosilicas Containing Interconnected [Si(CH 2 )] 3 Rings (2003)

A periodic mesoporous organosilica composed of interconnected three-ring [Si(CH2)]3 units built of three SiO2(CH2)2 tetrahedral subunits is reported. It represents the archetype of a previously unknown class of nanocomposite materials in which two bridging organic groups are bound to each silicon atom. It can be obtained with powder and oriented film morphologies. The nanocomposite is self-assembled from the cyclic three-ring silsesquioxane [(EtO)2Si(CH2)]3 precursor and a surfactant mesophase to give a well-ordered mesoporous framework. Low dielectric constants and good mechanical stability of the films were measured, making this material interesting for microelectronic applications. Methylene group reactivity of the three-ring precursor provides entry to a family of nanocomposites, exemplified by the synthesis and self-assembly of [(EtO)2Si(CHR)][(EtO)2Si(CH2)]2 (where R indicates iodine, bromine, or an ethyl group).
Partial power DC-DC converter for large-scale photovoltaic systems (2016)

In photovoltaic (PV) systems, a wide variety of power converter topologies and PV configurations have been developed in order to increase the system efficiency. Traditionally, grid-connected PV systems use one or two conversion stages. The single conversion stage is mainly used for large-scale PV systems working with only a DC-AC converter. Whereas, for small and medium-scale, two conversion stages are used. The advantages working with a DC-stage are mainly the distributed maximum power point tracking (MPPT) algorithm and the elevation capability, but it presents a reduced conversion efficiency compared with the single stage configurations. On the other hand, the single conversion stage presents a reduced overall efficiency produced by partial shading. The proposed work presents a Partial Power DC-DC converter (PPC) which process only a portion of the whole power, reducing the conversion losses. It includes the benefits of two stage configurations so that it performs individual MPPT. Besides, due to the modularity of the architecture, it allows the parallel connection of many strings as required to use in large-scale PV systems. Simulations are performed in order to evaluate the converter performance.
Evaluation of synthetic formaldehyde and methanol assimilation pathways in Yarrowia lipolytica (2019)

In silico, the expression of heterologous formaldehyde assimilation pathways enable <i>Y. lipolytica</i> to use methanol as substrate for growth and metabolite production. In vivo, methanol was shown to be converted to formaldehyde and the enzymes of formaldehyde assimilation were actively expressed in this yeast. However, further development is required to enable <i>Y. lipolytica</i> to efficiently use methanol as co-substrate with glycerol.
Micro/nano technologies towards smart systems integration (2010)

The micro and nano system technologies as well as electronics are playing a key role in today's product development and industrial progress. They enable the integration of mechanical, electrical, optical, chemical, biological and other functions into a very small space with dimensions ranging from sub micrometers up to some millimeters. This paper presents different examples of MEMS sensors and systems developed at Fraunhofer ENAS and Chemnitz University of Technology. It starts with silicon based technologies applied for MEMS laser displays and miniaturized MEMS spectrometer. The integration of new materials and new technologies is shown for point of care diagnostics.
Durable Nonwoven Fabrics via Fracturing Bicomponent Islands-in-the-Sea Filaments (2008)

This paper deals in general with fabrics consisting of bicomponent fibers that are fractured/fibrillated and bonded using mechanical and/or thermal means to form micro-denier fibers. Bicomponent filaments produced by the spunbonding process, where two polymers are co-extruded to form a fiber are used to demonstrate the feasibility of fracturing bicomponents. This process of nonwoven fabric manufacture combined with the fiber-fracturing process is discussed. These fabrics are processed using commercially accepted practices. Differences in the physical properties due to the different polymer ratios and cross-sections produced are discussed. In particular, this paper deals with the production of modified ‘Islands-in-the-Sea’ filament cross-sections that enhance the fracturing of such filaments to produce micro-fiber webs that have considerably higher surface area compared to their conventional counterparts. Point-bond calendered bicomponent samples were also tested for their mechanical properties with different island counts and polymer compositions. The optimal bonding techniques for the fabrics were identified. The role of the Islands-in-the-Sea fiber cross-section was demonstrated for optimizing the fabric strength and enhancement of surface area.
Batch-Fabricated High-Power RF Microrelays With Direct On-PCB Packages (2012)

This paper describes a process for batch manufacturing, assembly, and packaging of metal alloy microrelays directly on printed circuit board (PCB) substrates for high-power radio frequency (RF) applications. Stainless steel cantilevers with Pt-Rh tips are mounted on Rogers 4003 PCB substrates to demonstrate the approach. A multilayer PCB design allows for the use of subsurface metal layers to transmit the RF signal into and out of the sealed encapsulation. The electrostatically actuated microrelays with 8.4- footprints have 78-V pull-in voltage and 1.1- on-state resistance. Packaged microrelays exhibit down-state insertion loss and up-state isolation better than 0.25 and 15 dB, respectively, for frequencies up to 5 GHz. Packaged devices remain functional up to 20-W RF power under hot switching conditions. The high power lifetime of the microrelays is 10 913 cycles for 1-W incident RF power in 1-s pulses and 8414 cycles for 10-W incident RF power in 0.1-s pulses. The impact of device encapsulation and multilayer PCB substrate on device performance is addressed.
Effect of Exposure to a Radiofrequency Electromagnetic Field on Body Temperature in Anesthetized and Non‐Anesthetized Rats (2019)

Exposure to a radiofrequency (RF) signal at a specific absorption rate (SAR) of 4 W/kg can increase the body temperature by more than 1 °C. In this study, we investigated the effect of anesthesia on the body temperature of rats after exposure to an RF electromagnetic field at 4 W/kg SAR. We also evaluated the influence of body mass on rats' body temperature. Rats weighing 225 and 339 g were divided into sham- and RF-exposure groups. Each of the resulting four groups was subdivided into anesthetized and non-anesthetized groups. The free-moving rats in the four RF-exposure groups were subjected to a 915 MHz RF identification signal at 4 W/kg whole-body SAR for 8 h. The rectal temperature was measured at 1-h intervals during RF exposure using a small-animal temperature probe. The body temperatures of non-anesthetized, mobile 225 and 339 g rats were not significantly affected by exposure to an RF signal. However, the body temperatures of anesthetized 225 and 339 g rats increased by 1.9 °C and 3.3 °C from baseline at 5 and 6 h of RF exposure, respectively. Three of the five 339 g anesthetized and exposed rats died after 6 h of RF exposure. Thus, anesthesia and body mass influenced RF exposure-induced changes in the body temperature of rats. Bioelectromagnetics. 2020;41:104-112. © 2019 Bioelectromagnetics Society.
Use of broadly neutralizing antibodies for HIV‐1 prevention (2017)

Antibodies have a long history in antiviral therapy, but until recently, they have not been actively pursued for HIV-1 due to modest potency and breadth of early human monoclonal antibodies (MAbs) and perceived insurmountable technical, financial, and logistical hurdles. Recent advances in the identification and characterization of MAbs with the ability to potently neutralize diverse HIV-1 isolates have reinvigorated discussion and testing of these products in humans, since new broadly neutralizing MAbs (bnMAbs) are more likely to be effective against worldwide strains of HIV-1. In animal models, there is abundant evidence that bnMAbs can block infection in a dose-dependent manner, and the more potent bnMAbs will allow clinical testing at infusion doses that are practically achievable. Moreover, recent advances in antibody engineering are providing further improvements in MAb potency, breadth, and half-life. This review summarizes the current state of the field of bnMAb protection in animal models as well as a review of variables that are critical for antiviral activity. Several bnMAbs are currently in clinical testing, and we offer perspectives on their use as pre-exposure prophylaxis (PrEP), potential benefits beyond sterilizing immunity, and a discussion of future approaches to engineer novel molecules.
Heat Transfer Study of Polypropylene-Based Intumescent Systems during Combustion (1997)

We have studied the fire behavior and the heat transfer in the in tumescent formulations polypropylene (PP)-ammonium polyphosphate (APP)/pentaerythritol (PER) and PP-Hostaflam AP750 (AP750). We have shown that the fire proofing properties (LOI, UL-94 and cone calorimeter) of PP was strongly improved using the commercial additive AP750 in comparison with the system APP/PER. This is explained by the protection of the intumescent coating developed from PP-AP750 which is still efficient at high temperature (450-550°C) and which is developed faster. The measurement of temperature profiles in the conditions of the cone calorimeter shows that the temperatures reached with PP- AP750 are lower than these obtained with PP-APP/PER. Moreover, the tempera ture of PP-AP750 always remains lower than the temperature of the beginning of the fast degradation rate of PP which implies that there is never a fast degrada tion of the polymeric matrix. Finally, the computation of the temperature of the degradation front ( T d ) allows to conclude that low T d and relatively high displace ment rate of the place of the degradation front is needed to increase the efficiency of intumescent systems.
Advances in Allogeneic Cancer Cell Therapy and Future Perspectives on “Off-the-Shelf” T Cell Therapy Using iPSC Technology and Gene Editing (2022)

The concept of allogeneic cell therapy was first presented over 60 years ago with hematopoietic stem cell transplantation. However, complications such as graft versus host disease (GVHD) and regimen-related toxicities remained as major obstacles. To maximize the effect of graft versus leukemia, while minimizing the effect of GVHD, donor lymphocyte infusion was utilized. This idea, which was used against viral infections, postulated that adoptive transfer of virus-specific cytotoxic T lymphocytes could reconstitute specific immunity and eliminate virus infected cells and led to the idea of banking third party cytotoxic T cells (CTLs). T cell exhaustion sometimes became a problem and difficulty arose in creating robust CTLs. However, the introduction of induced pluripotent stem cells (iPSCs) lessens such problems, and by using iPSC technology, unlimited numbers of allogeneic rejuvenated CTLs with robust and proliferative cytotoxic activity can be created. Despite this revolutionary concept, several concerns still exist, such as immunorejection by recipient cells and safety issues of gene editing. In this review, we describe approaches to a feasible "off-the-shelf" therapy that can be distributed rapidly worldwide. We also offer perspectives on the future of allogeneic cell cancer immunotherapy.
Partial scan artifact reduction (PSAR) for the assessment of cardiac perfusion in dynamic phase‐correlated CT (2009)

The phase-correlated data now appear accurate enough for a quantitative analysis of cardiac perfusion.