gebhart/patrepeval huggingface dataset:
Variability Analysis for sub-100nm PD/SOI Sense-Amplifier (2008)

In this paper we perform a comprehensive analysis of the robustness of PD/SOI sense amplifiers considering floating body effect and random dopant fluctuation effect. Our analysis shows that, minimization of effects of floating body and random dopant fluctuations impose conflicting sizing requirements for different transistors in a sense amplifier. We develop a methodology for sizing of different devices to minimize the input offset voltage of sense amplifier. The proposed analysis and sizing methodology improve the robustness of PD/SOI sense amplifiers and can better exploit the performance advantages of PD/SOI technology.
On Benefits and Challenges of Conditional Interframe Video Coding in Light of Information Theory (2022)

The rise of variational autoencoders for image and video compression has opened the door to many elaborate coding techniques. One example here is the possibility of conditional interframe coding. Here, instead of transmitting the residual between the original frame and the predicted frame (often obtained by motion compensation), the current frame is transmitted under the condition of knowing the prediction signal. In practice, conditional coding can be straightforwardly implemented using a conditional autoencoder, which has also shown good results in recent works. In this paper, we provide an information theoretical analysis of conditional coding for inter frames and show in which cases gains compared to traditional residual coding can be expected. We also show the effect of information bottlenecks which can occur in practical video coders in the prediction signal path due to the network structure, as a consequence of the data-processing theorem or due to quantization. We demonstrate that conditional coding has theoretical benefits over residual coding but that there are cases in which the benefits are quickly canceled by small information bottlenecks of the prediction signal.
New Technique Combined with Suture and Incision Method for Creating a More Physiologically Natural Double-Eyelid (2009)

The advantages of the authors' technique are as follows: (1) the process of forming a double-eyelid is natural; (2) the power of the levator palpebrae muscle regarding the eye-opening process is transmitted to pull up the entire lid margin, allowing the eyes to be easily opened with minimal effort; and (3) there is minimal surgical scarring when the eyes are closed.
The Proteolytic Processing of Seed Storage Proteins inArabidopsisEmbryo Cells Starts in the Multivesicular Bodies (2006)

We have investigated the transport of storage proteins, their processing proteases, and the Vacuolar Sorting Receptor-1/Epidermal Growth Factor Receptor-Like Protein1 (VSR-1/ATELP1) receptor during the formation of protein storage vacuoles in Arabidopsis thaliana embryos by means of high-pressure freezing/freeze substitution, electron tomography, immunolabeling techniques, and subcellular fractionation. The storage proteins and their processing proteases are segregated from each other within the Golgi cisternae and packaged into separate vesicles. The storage protein-containing vesicles but not the processing enzyme-containing vesicles carry the VSR-1/ATELP1 receptor. Both types of secretory vesicles appear to fuse into a type of prevacuolar multivesicular body (MVB). We have also determined that the proteolytic processing of the 2S albumins starts in the MVBs. We hypothesize that the compartmentalized processing of storage proteins in the MVBs may allow for the sequential activation of processing proteases as the MVB lumen gradually acidifies.
Re: VHL-Regulated miR-204 Suppresses Tumor Growth Through Inhibition of LC3B-Mediated Autophagy in Renal Clear Cell Carcinoma (2012)

No AccessJournal of UrologyInvestigative Urology1 Dec 2012Re: VHL-Regulated miR-204 Suppresses Tumor Growth Through Inhibition of LC3B-Mediated Autophagy in Renal Clear Cell Carcinoma Anthony AtalaM.D. Anthony AtalaAnthony Atala View All Author Informationhttps://doi.org/10.1016/j.juro.2012.08.067AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: VHL-Regulated miR-204 Suppresses Tumor Growth Through Inhibition of LC3B-Mediated Autophagy in Renal Clear Cell Carcinoma." The Journal of Urology, 188(6), p. 2434 © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 188Issue 6December 2012Page: 2434 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement Loading ...
Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses (2014)

Our biochemical analysis supports the hypothesis that the enzymological properties, particularly, K m values, of lentivirus RTs, are mechanistically tied with the cellular dNTP availability in nondividing target cells, which is controlled by SAMHD1 and Vpx.
High-power single-mode eye-safe wavelength semiconductor lasers (2008)

We present recent advances in high power semiconductor laser bars and arrays at near infrared and eye-safe wavelengths. We report on increased spectral brightness with internal gratings to narrow and stabilize the spectrum and increased spatial brightness in multimode and single mode devices. These devices have the potential to dramatically improve diode pumped systems and enable new direct diode applications.
Parameters A Reduced Sampling Schedule for Estimating the of the Glucose Minimal Model from (1991)

The minimal model of tracer glucose disappear- ance allows the measurement in man of important metabolic parameters from a labeled IVGTT (intravenous glucose toler- ance test). Usually 30 blood samples are drawn to measure the insulin and the labelled glucose concentration time courses, which provide the data base for the model identification. In this paper, we address the problem of reducing the number of blood samples withdrawn without, however, deteriorating parameter estimation. By using a stepwise approach, largely based on op- timal experiment design theory, we have derived a reliable re- duced sampling schedule, which comprises only 14 total sam- ples. The practical application of this reduced schedule has been validated by applying it in a new set of human experiments, completely independent of the ones used in the design phase.
Extracting flexible, replayable models from large block traces (2012)

I/O traces are good sources of information about realworld workloads; replaying such traces is often used to reproduce the most realistic system behavior possible. But traces tend to be large, hard to use and share, and inflexible in representing more than the exact system conditions at the point the traces were captured. Often, however, researchers are not interested in the precise details stored in a bulky trace, but rather in some statistical properties found in the traces--properties that affect their system's behavior under load.We designed and built a system that (1) extracts many desired properties from a large block I/O trace, (2) builds a statistical model of the trace's salient characteristics, (3) converts the model into a concise description in the language of one or more synthetic load generators, and (4) can accurately replay the models in these load generators. Our system is modular and extensible. We experimented with several traces of varying types and sizes. Our concise models are 4-6% of the original trace size, and our modeling and replay accuracy are over 90%.
Ultrafast dynamics of nonlinear refraction (2018)

We introduce the nonlinear beam deflection technique that allows unambiguous separation of slow and fast nonlinearities. This highly sensitive method allowed characterization of a wide range of materials, including solvents, gases, semiconductors and transparent conducting oxides.
Inert gas jets for growth control in electron beam induced deposition (2011)

An inert, precursor free, argon jet is used to control the growth rate of electron beam induced deposition. Adjustment of the jet kinetic energy/inlet temperature can selectively increase surface diffusion to greatly enhance the deposition rate or deplete the surface precursor due to impact-stimulated desorption to minimize the deposition or completely clean the surface. Physical mechanisms for this process are described. While the electron beam is also observed to generate plasma upon interaction with an argon jet, our results indicate that plasma does not substantially contribute to the enhanced deposition rate.
Fast scans and joins using flash drives (2008)

As access times to main memory and disks continue to diverge, faster non-volatile storage technologies become more attractive for speeding up data analysis applications. NAND flash is one such promising substitute for disks. Flash offers faster random reads than disk, consumes less power than disk, and is cheaper than DRAM. In this paper, we investigate alternative data layouts and join algorithms suited for systems that use flash drives as the non-volatile store.
Mechanism of Direct Adhesion between Peroxide-Crosslinking EPDM and Plastics (2006)

Ethylene-propylene-diene rubber (EPDM) compounded with dicumyl peroxide (DCP) and modified polyphenylene ether (mPPE) are bonded directly without an adhesive on the conditions of rubber crosslinking. In this study, the mechanism of the direct adhesion between EPDM compounded with DCP and mPPE was investigated. In addition, polyamide 66 (PA66) and polyoxymethylene (POM) instead of mPPE were studied.The EPDM/mPPE composite resulted in a breakage of the EPDM layer in adhesive strength tests. In order to analyze the interface, mPPE was dissolved in chloroform. It has been found that a crosslinking mPPE layer was formed in the interface by using attenuated total reflection Fourier transform infrared (ATR-FT-IR) spectroscopy, and the crosslinking layer was built by DCP diffusing from EPDM into mPPE. Carbon radicals in the mixture of mPPE and DCP were detected by electron spin resonance (ESR) at the crosslinking temperature (180°C). On the other hand, the interfacial failure was occurred in EPDM/PA66 composite, because DCP diffusing into PA66 didn't efficiently affect radical generation in PA66: In the EPDM/POM composite, the interfacial failure occurred, because POM was not crosslinked by DCP diffusing into POM.
ChemInform Abstract: A New Protecting Group for the Sulfhydryl Function of Cysteine. (1989)

Abstract The thiocarbamoylsulfenylcysteine (IV) and the related methoxycarbonylsulfenyl derivative (VIII) are prepared as shown in the reaction scheme and stored in the form of their dicyclohexylammonium salts.
Phosphorylation of STAT-3 in Response to Basic Fibroblast Growth Factor Occurs through a Mechanism Involving Platelet-activating Factor, JAK-2, and Src in Human Umbilical Vein Endothelial Cells (2002)

Platelet-activating factor (PAF) is a potent proinflammatory phospholipid with multiple pathological and physiological effects. We have shown that basic fibroblast growth factor (bFGF) supplementation induces rapid proliferation of human umbilical vein endothelial cells (HUVEC), which is reduced upon removal of bFGF or by bFGF immunoneutralization. The PAF receptor antagonist LAU-8080 inhibited bFGF-stimulated HUVEC proliferation, indicating the involvement of PAF in the bFGF-mediated signaling of HUVEC. Although FGF receptor phosphorylation was not affected by LAU-8080, the bFGF-mediated prolonged phosphorylation, and activation of Erk-1 and -2 were attenuated. Phosphorylation of STAT-3 was observed in the presence of PAF or bFGF, which was attenuated by PAFR antagonists. PAF-induced STAT-3 phosphorylation observed in HUVEC pretreated with either Src inhibitor PP1 or JAK-2 inhibitor AG-490 indicated (i) immediate (1 min) phosphorylation of STAT-3 is dependent on Src, (ii) JAK-2-dependent STAT-3 phosphorylation occurs after the delayed (30 min) PAF exposure, and (iii) prolonged (60 min) STAT-3 phosphorylation may be either through Src and/or JAK-2. Attenuation of the STAT-3 phosphorylation by the PAFR antagonists indicated signaling through the PAF receptor. Taken together, these findings suggest the production of PAF is important for bFGF-mediated signaling and that a dual kinase mechanism is involved in the PAF-mediated signal transduction cascade.
Novel liver‐specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate† (2007)

OAT7 is the first liver-specific transporter among members of the organic anion transporters of SLC22 family. Our findings suggest a new class of substrates for organic anion transporters and provide evidence for the transport of anionic substances such as sulfate-conjugates in exchange for butyrate in hepatocytes.
Co-operation of digital nonlinear equalizers and soft-decision LDPC FEC in nonlinear transmission (2013)

We experimentally and numerically investigated the characteristics of 128 Gb/s dual polarization - quadrature phase shift keying signals received with two types of nonlinear equalizers (NLEs) followed by soft-decision (SD) low-density parity-check (LDPC) forward error correction (FEC). Successful co-operation among SD-FEC and NLEs over various nonlinear transmissions were demonstrated by optimization of parameters for NLEs.
Parvovirus H1-induced tumor cell death enhances human immune response via crosspresentation of dendritic cells (2004)

Address: 1I. Medical Department, University of Mainz, Langenbeckstr.1, D-55101 Mainz, Germany, 2Deutsches Krebsforschungszentrum, Applied Tumor Virology, Dept. F0100, and Institut National de la Sante et de la Recherche Medicale Unite 375, Im Neuenheimer Feld 242, D-69120 Heidelberg, Germany, 3III. Medical Department, University of Mainz, Langenbeckstr.1, D-55101 Mainz, Germany and 4Med. Department Mitte, Klinikum Dortmund GmbH, Beurhausstr. 10, 44137 Dortmund, Germany
Polyacrylamide Injection vs. Polylactic Acid in HIV Related Lipodystrophy: A RCT Systematic Review (2021)

Lipodystrophy is an alteration of fat metabolism that commonly affects HIV-1 positive patients treated with antiretroviral therapy (ART). The facial area is most commonly affected by peripheral lipoatrophy, thus becoming a social stigma related to chronic HIV. Several treatments have been proposed, such as modification of diet, lifestyle and both surgical and nonsurgical procedures. The goal of our systematic review is to examine published clinical studies involving the use of polyacrylamide filler for the treatment of HIV FLA, and to provide evidence-based recommendations based on published efficacy and safety data. Our research was performed on published literature until April 2021. Polyacrylamide gel is a volumetric gel that has been proven stable, nontoxic, nonallergenic, nonembryotoxic and nonabsorbable. Poly-l-lactic acid (PLA) is a biocompatible, biodegradable, synthetic polymer derived from lactic acid. We believe it is essential to draft a pre- and post-injection and operative protocol to define an even setting for the clinical condition. It is desirable that such specifications are included in a large randomized controlled trial and the follow up is longer than the studies that we found, because as we have seen in the literature there are reported adverse events even 3 or 5 years after the injections.
Detailed SET Measurement and Characterization of a 65 nm Bulk Technology (2016)

Single Event Transients (SETs) are a major concern for space applications, particularly when hardened flip flops are used to reduce the sensitivity of sequential logic. Characterizing SETs is complex as both the cross section and the pulse width must be measured. In the 65 nm test chip presented in this paper, three different SET measurement circuits, implemented on the same die, are characterized and compared. Using these SET detectors, heavy-ion test results are presented. The detectors are compared and a detailed study of the SET sensitivity of multiple gates operating at different logical, load and voltage conditions is presented.
Overexpression of Bcl-2 Differentially Restores Development of Thymus-Derived CD4−8+ T Cells and Intestinal Intraepithelial T Cells in IFN-Regulatory Factor-1-Deficient Mice (2001)

Mice lacking IFN-regulatory factor (IRF)-1 have reduced numbers of mature CD8+ T cells within the thymus and peripheral lymphoid organs, suggesting a critical role of IRF-1 in CD8(+) T cell differentiation. Here we show that endogenous Bcl-2 expression is substantially reduced in IRF-1(-/-)CD8+ thymocytes and that introduction of a human Bcl-2 transgene driven by Emu or lck promoter in IRF-1(-/-) mice restores the CD8(+) T cell development. Restored CD8+ T cells are functionally mature in terms of allogeneic MLR and cytokine production. In contrast to thymus-derived CD8+ T cells, other lymphocyte subsets including NK, NK T, and TCR-gammadelta(+) intestinal intraepithelial lymphocytes, which are also impaired in IRF-1(-/-) mice, are not rescued by expressing human Bcl-2. Our results indicate that IRF-1 differentially regulates the development of these lymphocyte subsets and that survival signals involving Bcl-2 are critical for the development of thymus-dependent CD8+ T cells.
P21-Activated Kinase 1 (PAK1) as a Therapeutic Target in BRAF Wild-Type Melanoma (2013)

Taken together, our results provide evidence for a functional role of PAK1 in BRAF wild-type melanoma and therapeutic use of PAK inhibitors in this indication.
Sensitivity and Noise Evaluation of a Bonded Magneto(elasto) Electric Laminated Sensor Based on In-Plane Magnetocapacitance Effect for Quasi-Static Magnetic Field Sensing (2015)

The quasi-static magnetic field detection of a layer-bonded magneto(elasto) electric (ME) laminate has been investigated by measuring the in-plane electric capacitance via its interdigital electrodes close to the piezoelectric resonant frequency. The ME-layered composite is considered as a stress-induced dielectric effect because there is practically no direct response of the electric capacitance to an external magnetic field. The sensitivity is dominated by the magnetoelastic coupling in the magnetic layer and on the stress induced by the permittivity change in the piezoelectric layer. The low-frequency magnetocapacitance effect is sensitive to an external magnetic bias which can modulate the electric permittivity by producing a stress. The magnetoelastic coupling is another important parameter for this magnetic field detection mode. For a given magnetic field, the amplitude of the magnetostriction is directly related to this parameter as well. Therefore, an optimal magnetic bias can maximize the induced strain or stress which is coupled into the piezoelectric layer through the change of the electric permittivity in this layer. To evaluate the sensitivity and the noise performance by the magnetocapacitance effect, we have used the piezoelectric and magnetic constitutive equations to predict the permittivity dependence. Experimentally, this sensor achieved an equivalent magnetic noise spectral density, presently still limited, by the noise of the detection electronics, ~100 pT/√Hz at 1 Hz and offered a dc detection capability. With the model and experimental nonlinear factors, an equivalent sensor noise spectral density close to the pT/√Hz can be ultimately predicted considering the mechanical loss limitation of the sensor.
Psychologically-Inspired Audio-Visual Speech Recognition Using Coarse Speech Recognition and Missing Feature Theory (2017)

[abstFig src='/00290001/10.jpg' width='300' text='System architecture of AVSR based on missing feature theory and P-V grouping' ] Audio-visual speech recognition (AVSR) is a promising approach to improving the noise robustness of speech recognition in the real world. For AVSR, the auditory and visual units are the phoneme and viseme, respectively. However, these are often misclassified in the real world because of noisy input. To solve this problem, we propose two psychologically-inspired approaches. One is audio-visual integration based on missing feature theory (MFT) to cope with missing or unreliable audio and visual features for recognition. The other is phoneme and viseme grouping based on coarse-to-fine recognition. Preliminary experiments show that these two approaches are effective for audio-visual speech recognition. Integration based on MFT with an appropriate weight improves the recognition performance by −5 dB. This is the case even in a noisy environment, in which most speech recognition systems do not work properly. Phoneme and viseme grouping further improved the AVSR performance, particularly at a low signal-to-noise ratio. * * This work is an extension of our publication “Tomoaki Koiwa et al.: Coarse speech recognition by audio-visual integration based on missing feature theory, IROS 2007, pp.1751-1756, 2007.”
Secreted Phospholipase A2 Group X Overexpression in Asthma and Bronchial Hyperresponsiveness (2007)

Increased expression of sPLA(2)-X may play a key role in the dysregulated eicosanoid synthesis in asthma.
Presentation and management of parasellar and suprasellar metastatic mass lesions. (1985)

Ten patients with parasellar metastatic lesions presented with insidious painful or painless ophthalmoplegia. Visual loss secondary to a chiasmal syndrome was identified in three of them. A mass lesion was demonstrated by CT scan with precise outlining of the location and size of the lesion. Symptomatic relief was achieved with local radiotherapy in those patients who had early diagnosis.
Polymer waveguides and thermo-optical switches for an optical true time delay phased array antenna (2005)

The design and fabrication of a polymer optical waveguide based true time delay (TTD) device is described. Optimization of the fabrication process decreased the waveguide propagation loss from more than 1.55 dB/cm to 0.38 dB/cm at a wavelength of 1.55um. Waveguide bend loss structures were fabricated and measurement results were compared to simulations. A bend radius of 3 mm provides low insertion loss and small device size. 2x2 thermo-optic TIR switches were fabricated with insertion losses of 2.8 dB. A 4-bit TTD device for use with a 4x4 sub-array of a 10GHz phased array antenna was calculated to have an insertion loss of 23.88 dB.