gebhart/patrepeval huggingface dataset:
A practical methodology for guaranteeing quality of service for video-on-demand (2000)

A novel and simple approach for defining end-to-end quality of service (QoS) in video-on-demand (VoD) services is presented. Using this approach, we derive a schedulable region for a video server which guarantees end-to-end QoS, where a specific QoS required in the video client translates into a QoS specification for the video server. Our methodology is based on a generic model for VoD services, which is extendible to any VoD system. In this kind of system, both the network and the video server are potential sources of QoS degradation. Specifically, we examine the effect that impairments in the video server and video client have on the video quality perceived by the end user. The Columbia VoD testbed is presented as an example to validate the model through experimental results. Our model can be connected to network QoS admission control models to create a unified approach for admission control of incoming video requests in the video server and network.
ChemInform Abstract: Visible‐Light‐Induced Reversible Photomagnetism in Rubidium Manganese Hexacyanoferrate. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ki-67 Expression in Breast Cancer Tissue Microarrays (2017)

Ki-67 tumor heterogeneity was common in luminal/HER2- BC. Using a weighted approach was better than using a mitotically active approach for core to case collapsing. At least a single 1.0-mm core or three 0.6-mm cores are required when designing a study using TMA.
Release Factor Inhibiting Antimicrobial Peptides Improve Nonstandard Amino Acid Incorporation in Wild-type Bacterial Cells (2020)

We report a tunable chemical genetics approach for enhancing genetic code expansion in different wild-type bacterial strains that employ apidaecin-like, antimicrobial peptides observed to temporarily sequester and thereby inhibit Release Factor 1 (RF1). In a concentration-dependent matter, these peptides granted a conditional lambda phage resistance to a recoded <i>Escherichia coli</i> strain with nonessential RF1 activity and promoted multisite nonstandard amino acid (nsAA) incorporation at in-frame amber stop codons <i>in vivo</i> and <i>in vitro</i>. When exogenously added, the peptides stimulated specific nsAA incorporation in a variety of sensitive, wild-type (RF1+) strains, including <i>Agrobacterium tumefaciens</i>, a species in which nsAA incorporation has not been previously reported. Improvement in nsAA incorporation was typically 2-15-fold in <i>E. coli</i> BL21, MG1655, and DH10B strains and <i>A. tumefaciens</i> with the >20-fold improvement observed in probiotic <i>E. coli</i> Nissle 1917. In-cell expression of these peptides promoted multisite nsAA incorporation in transcripts with up to 6 amber codons, with a >35-fold increase in BL21 showing moderate toxicity. Leveraging this RF1 sensitivity allowed multiplexed partial recoding of MG1655 and DH10B that rapidly resulted in resistant strains that showed an additional approximately twofold boost to nsAA incorporation independent of the peptide. Finally, in-cell expression of an apidaecin-like peptide library allowed the discovery of new peptide variants with reduced toxicity that still improved multisite nsAA incorporation >25-fold. In parallel to genetic reprogramming efforts, these new approaches can facilitate genetic code expansion technologies in a variety of wild-type bacterial strains.
“I’ll Be Back”: The Resurrection of Dezocine (2021)

Beginning with opium itself, natural and synthetic opioids have been used as analgesics for over 8000 years and were likely abused as drugs of recreation for that long as well. However, the "opioid crisis" resulted in attempts to avoid or limit opioid analgesics in favor of other therapies and methods. Mu opioid agonists can be effective analgesics but suffer from addiction, tolerance, and dangerous, sometimes fatal, side effects. One exception to this generalization is dezocine (Dalgan), a mixed mu/kappa opioid partial agonist. Dezocine is at least as effective as morphine in reducing acute pain in animal models and clinical applications such as postoperative pain. And while dezocine was discontinued in western markets in 2011, it has become the favored opioid analgesic in China, capturing over 40% of the market. Additionally, dezocine possesses norepinephrine uptake inhibitory activity, which may synergize with mu agonism in the case of acute pain treatment and possibly endow the drug with antinociceptive activity in neuropathic pain conditions. This Innovations article summarizes the history and properties of dezocine and presents evidence and rationale for why dezocine has undergone a resurrection.
Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1 (2023)

Nuclear receptor-binding SET-domain protein 1 (NSD1), a methyltransferase that catalyzes H3K36me2, is essential for mammalian development and is frequently dysregulated in diseases, including Sotos syndrome. Despite the impacts of H3K36me2 on H3K27me3 and DNA methylation, the direct role of NSD1 in transcriptional regulation remains largely unknown. Here, we show that NSD1 and H3K36me2 are enriched at cis-regulatory elements, particularly enhancers. NSD1 enhancer association is conferred by a tandem quadruple PHD (qPHD)-PWWP module, which recognizes p300-catalyzed H3K18ac. By combining acute NSD1 depletion with time-resolved epigenomic and nascent transcriptomic analyses, we demonstrate that NSD1 promotes enhancer-dependent gene transcription by facilitating RNA polymerase II (RNA Pol II) pause release. Notably, NSD1 can act as a transcriptional coactivator independent of its catalytic activity. Moreover, NSD1 enables the activation of developmental transcriptional programs associated with Sotos syndrome pathophysiology and controls embryonic stem cell (ESC) multilineage differentiation. Collectively, we have identified NSD1 as an enhancer-acting transcriptional coactivator that contributes to cell fate transition and Sotos syndrome development.
Parameterized GSPN Model and Extended Dependability Block Diagram for Reliability Evaluation of Embedded Systems (2006)

In this study we focus on the specification and evaluation of parameterized generalized and stochastic Petri net (GSPN) models for reliability and safety estimates of embedded systems. The embedded system to be modeled is specified using the extended dependability block diagram (EDBD), a high-level system specification model, which is composed of several and diverse blocks: functional, decision, standby spare, multiple and subsystem. For each block, parameterized GSPN model parameters may be defined as: failure and repair rates, failure and success probabilities, redundancy and number of redundant components (if any), mean time to failure (MTTF) and mean time to repair (MTTR) among others. The parameterized solution helps the development of high-level automation tools. The parameterized GSPN models are concise and changeable models, based on few block models (with small variations). These models, depending on the parameters, can assume different structural configuration. Through Markovian and non-Markovian distributions functions, evaluation of series, parallel, m-out-of-n and other complex structures are possible. Non-Markovian distributions can be represented by composition of exponential distributions by means of method-of-stages through moment matching technique or by analytical expressions into a random switch, a GSPN construct. At the end, a case study related to a flight-control system solution is presented and estimates are shown which validate the proposed model.
INFLUENCE OF THE γ' FRACTION ON THE γ/γ' TOPOLOGICAL INVERSION DURING HIGH TEMPERATURE CREEP OF SINGLE CRYSTAL SUPERALLOYS (2008)

Evolution of the γ/γ’ microstructure during creep at 1050°C and 150 MPa of the AM1, MC2 and MC544 single crystal superalloys was followed and quantified by evaluating the varia tion of the specific connectivity number of the γ’ phase N A(γ’). Complementary assessments of the γ’ phase connectivity were performed on a modified MC544 alloy with a reduced amount of γ’ phase and on Rene N6 and CMSX-10M third generation superalloys. The transition from the secondary to t he tertiary creep stage is correlated to the topological inversion of the γ/γ’ microstructure. The γ’ phase initially surrounded by the γ phase matrix becomes progressively the connected phase as the creep deformation increases. This topological inversion o ccurs during creep of single crystal superalloys when the γ’ phase fraction is higher than about 50% and therefore depends on the alloy chemistry and on the temperature. The γ/γ ' topological inversion occurs sooner during creep as γ ' amount increases above 50%.
A new model for the coarsening of cocontinuous morphologies (2010)

The coarsening of fluorescently labeled polystyrene/ styrene-ran-acrylonitrile copolymer symmetric blends with cocontinuous morphologies was studied with 3D imaging. Blends with three different interfacial tensions were analyzed. Two regimes of coarsening were observed: a linear growth of the characteristic size followed by a gradual decrease of the rate of coarsening. Only the linear regime was explained by the classical analysis of phase separating systems by Siggia (Phys. Rev. A, 1979, 20, 595). Here, we propose a new model which considers both the characteristic size and the interfacial curvature. This model is a generalization of Siggia's analysis, after including the contribution of the local curvature on the capillary pressure within the interconnected domains. Our capability to compute curvature data from 3D images of the blend microstructure allowed us to test our model. Additionally, a general expression for the coarsening rate proposed by Scholten et al. (E. Scholten, L. M. C. Sagis and E. van der Linden, Macromolecules, 2005, 38, 3515) was, for the first time, assessed here. Both early and late stages of coarsening were predicted with the new model, while Scholten et al. and Siggia's expressions are able to adequately describe only one stage. A crossover between the two regimes of coarsening took place at a single value of capillary number (Ca ∼ 0.003) for all three blends, as predicted by our new expression.
The Incidence of Dental Fracturing in Electroconvulsive Therapy in Sweden (2020)

There is a minimal risk of dental fracture during ECT. Our findings, together with those of other studies, provide further motivation for the use of a bite guard and muscle relaxant.
Retrospective Evaluation of Bayesian Risk Models of LVAD Mortality at a Single Implant Center (2018)

Use of a left ventricular assist device (LVAD) can benefit patients with end stage heart failure, but only with careful patient selection. In this study, previously derived Bayesian network models for predicting LVAD patient mortality at 1, 3, and 12 months post-implant were evaluated on retrospective data from a single implant center. The models performed well at all three time points, with a receiver operating characteristic area under the curve (ROC AUC) of 78, 76, and 75%, respectively. This evaluation of model performance verifies the utility of these models in "real life" scenarios at an individual institution.
TRACHEOBRONCHIAL CLEARANCE IN PATIENTS WITH INFLUENZA (1973)

1Summary _ Tracheobronchial clearance was studied in 6 patients infected with influenza A and 9 healthy subjects. A test aerosol that consisted of 6-p.m particles of teflon (density: 2 g per emS) tagged with technetium-99m was used, and radio­ activity in the lungs was measured externally for 2 hours. The patients with influenza were studied approximately 1 week, 1 month, and 3 months after the onset of symptoms. Clearance at the first examination was, on the average, significantly slower than on the second and third occasions. At the first study, clearance in the patients with influenza was significantly slower than that in the healthy subjects, where­ as on the second and third examinations, it was similar in the two groups.
Consolidation of Cr-Cu/Cu Powder Laminated Material by Compressive Torsion Processing (2014)

The Cu-Cr composite material is widely used as an electrode material in a vacuum circuit breakers used in electric power systems. It is generally produced by sintering processes, and then Cr particles were refined in the surface part. Using the Compressive Torsion Process (CTP) which is one of the severe plastic deformation processes, the Cu-Cr composite powder can be fully dense consolidated without sinter, and the Cr particles are refined in surface layer portion at the same time. In this study, the CTP was applied to the laminated material of Cu-Cr composite and Cu powders and the possibility of consolidation and Cr particle refinement of the laminated material was investigated. The consolidation of Cr-Cu/Cu laminated powder was possible by the CTP, and Cr particles near a drive end were extremely refined. Hardness and tensile strength of the laminated material were medium between both single Cu-Cr and Cu specimens. It means they were largest and the same level as Cu-Cr single composite near the end of a cylindrical specimen, and decreased gradually toward the middle part of Cu layer until the same level as Cu single material.
Terveyden eriarvoisuus Suomessa : ehdotus seurantajärjestelmän kehittämiseen (2021)

Suomalaisten terveys on yleisesti kehittynyt melko myönteisesti viime vuosikymmenten aikana eri mittarein tarkasteltuna, mutta väestöryhmien välillä on edelleen suuria terveyseroja (Aromaa &amp; Koskinen 2002; Karvonen ym. 2017; Koponen ym. 2018; Lahelma ym. 2017). Väestön terveys vaihtelee esimerkiksi sosioekonomisen aseman, sukupuolen, siviilisäädyn, asuinalueen ja äidinkielen mukaan. Nämä erot ovat erityisen korostuneita sosioekonomisten ryhmien välillä, eli kun tarkastellaanterveyden vaihtelua esimerkiksi koulutuksen, ammattiaseman tai tulojen mukaisesti. Terveyseroista tai terveyden eriarvoisuudesta puhuttaessa viitataankin yleensä sosioekonomisten ryhmien välillä ilmeneviin eroihin. Systemaattisia terveyseroja ilmenee esimerkiksi terveydentilassa, sairastavuudessa ja kuolleisuudessa.
Efficacy and Safety of Subcutaneous Vedolizumab in Patients With Moderately to Severely Active Crohn’s Disease: Results From the VISIBLE 2 Randomised Trial (2021)

Vedolizumab SC is an effective and safe maintenance therapy in patients with CD who responded to two infusions of vedolizumab intravenous induction therapy.
The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response (2014)

The epigenetic sensor BRD4 (bromodomain protein 4) is a potent target for anti-cancer therapies. To study the transcriptional impact of BRD4 in cancer, we generated an expression signature of BRD4 knockdown cells and found oxidative stress response genes significantly enriched. We integrated the RNA-Seq results with DNA-binding sites of BRD4 generated by chromatin immunoprecipitations, correlated these with gene expressions from human prostate cancers and identified 21 top BRD4 candidate genes among which the oxidative stress pathway genes KEAP1, SESN3 and HDAC6 are represented. Knock down of BRD4 or treatment with the BRD4 inhibitor JQ1 resulted in decreased reactive oxygen species (ROS) production and increased cell viability under H2O2 exposure. Consistently, a deregulation of BRD4 diminished the KEAP1/NRF2 axis and led to a disturbed regulation of the inducible heme oxygenase 1 (HMOX1). Without exogenous stress induction, we also found BRD4 directly targeting the HMOX1 promoter over the SP1-binding sites. Our findings provide insight into the transcriptional regulatory network of BRD4 and highlight BRD4 as signal transducer of the cellular response to oxidative stress.
Tuning Flux-pinning in Epitaxial NdBa2Cu3O7-δFilms via Engineered, Hybrid Nanoscale Defect Structures (2008)

Epitaxial NdBa2Cu3O7-x films with a hybrid nanoscale defect structure comprised of BaZrO3 nanodot arrays aligned along the c-axis in one half of the film thickness and aligned perpendicular to the c-axis in the other half thickness of the film were fabricated. Transmission electron microscopy images confirm the orientation of the nanoscale defect structures. The angular dependence of critical current density, Jc, at 77 K, 1 T, shows significantly reduced angular variation of Jc. This study nicely demonstrates how pinning characteristics can be tuned by tuning the nanoscale defect structures within the films.
Supplementary Data 3 from Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression (2023)

&lt;p&gt;PDF file - 2.78 MB&lt;/p&gt;
An optical microsystem based on vertical silicon-air Bragg mirror for liquid substances monitoring (2007)

In this work, an integrated optical microsystems for the continuous detection of flammable liquids has been fabricated and characterized. The proposed system is composed of a the transducer element, which is a vertical silicon/air Bragg mirror fabricated by silicon electrochemical micromachining, sealed with a cover glass anodically bonded on its top. The device has been optically characterized in presence of liquid substances of environmental interest, such as ethanol and isopropanol. The preliminary experimental results are in good agreement with the theoretical calculations and show the possibility to use the device as an optical sensor based on the change of its reflectivity spectrum.
Pediatric Traumatic and Obstetrical Brachial Plexus Palsy: Triceps to Axillary Nerve Transfers to Restore Shoulder Abduction (2010)

Plastic and Reconstructive Surgery: October 2010 - Volume 126 - Issue - p 91 doi: 10.1097/01.prs.0000388815.66047.70
Gas hydrates and semiclathrate hydrates for H2 and CH4 storage: Kinetics, capacity and stability (2009)

Gas hydrates (or clathrates) have potential advantages as materials for hydrogen or methane storage with respect to other gas storage technologies. For example, hydrates can trap gases such as hydrogen close to ambient temperature, quite unlike porous materials where cryogenic temperatures are required. We show that substantial quantities of methane (around 45 v/v) can be stored reversibly in certain semi-clathrate hydrate structures at atmospheric pressure and ambient temperature, again in contrast to physisorption approaches. Several challenges exist: for example, the quantity of hydrogen stored in gas hydrates is well below the Department of Energy (DoE) target of 6 wt. %. By contrast, pure methane hydrate in "dry water" form stores 175 v/v gas: that is, very close to the corresponding DoE target. This presentation will discuss approaches to storing gases (H2 and CH4) in hydrated form, in particular strategies for accelerating hydrate formation kinetics, minimizing storage pressure (ideally to 1 atm), and maximising gas storage capacity.
Vers une société de marché (2010)

Les années de gouvernement Blair-Brown ont conduit l’électorat britannique à de profondes déceptions. Le bilan de la politique travailliste mené par Florence Faucher-King et Patrick Le Galès dans leur livre, résumé\nici pour La Vie des Idées, contraste fortement avec celui du conseiller travailliste Julian Le Grand.
Novel board level drop test simulation using implicit transient analysis with input-G method (2005)

In recent several years, there are many efforts to study the reliability performance of IC package under drop impact loading by numerical modeling. Most of the models utilize LS-DYNA or ABAQUS types of explicit solvers. However, there is a lack of efficient implicit model for the organization without access to explicit solvers. This paper presents a novel non-linear transient dynamics model with implicit algorithm for board level drop test modeling using conventional finite element modeling framework such as ANSYS implicit solver. According to the JEDEC board level drop test standard, the impact pulse is compulsorily monitored during drop test qualification of components. This impact pulse includes the effects of velocity before and after impact, and the effects of contact surface and material, as well as drop tester's characteristics such as friction of guiding rods, which are too complicated to be simulated by conventional free-fall model. A lumped model with one degree of freedom mass-spring-damping system is proposed to describe the dynamic behaviors of PCB assembly under drop impact. Based on this model, the Input-G method using implicit transient dynamic analysis is derived and proven both theoretically and numerically. This method is more accurate and much faster, and bypasses many technical difficulties in conventional free-fall drop model such as adjusting the parameters of contact surfaces, defining contact type, and etc. The model established has good correlation with experimental measurement of dynamic strain, PCB center displacement, and vibration frequency as observed in actual drop test. This implicit method is comparable with explicit method developed in previous study in terms of solution time and accuracy. Its solution time is about 30% longer than explicit Input-G method, but much shorter than explicit free-fall model and implicit free-fall model. It is a good cost-saving alternative for organizations without access to explicit solver to perform drop test simulation.
Sensorimotor rhythm neurofeedback as adjunct therapy for Parkinson's disease (2017)

Neurofeedback may enhance compensatory brain mechanisms. EEG-based sensorimotor rhythm neurofeedback training was suggested to be beneficial in Parkinson's disease. In a placebo-controlled study in parkinsonian nonhuman primates we here show that sensorimotor rhythm neurofeedback training reduces MPTP-induced parkinsonian symptoms and both ON and OFF scores during classical L-DOPA treatment. Our findings encourage further development of sensorimotor rhythm neurofeedback training as adjunct therapy for Parkinson's disease which might help reduce L-DOPA-induced side effects.
Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy (2021)

Autophagy selectively degrades aggregation-prone misfolded proteins caused by defective cellular proteostasis. However, the complexity of autophagy may prevent the full appreciation of how its modulation could be used as a therapeutic strategy in disease management. Here, we define a molecular pathway through which recombinant IL-1 receptor antagonist (IL-1Ra, anakinra) affects cellular proteostasis independently from the IL-1 receptor (IL-1R1). Anakinra promoted H2O2-driven autophagy through a xenobiotic sensing pathway involving the aryl hydrocarbon receptor that, activated through the indoleamine 2,3-dioxygenase 1-kynurenine pathway, transcriptionally activated NADPH oxidase 4 independent of the IL-1R1. By coupling the mitochondrial redox balance to autophagy, anakinra improved the dysregulated proteostasis network in murine and human cystic fibrosis. We anticipate that anakinra may represent a therapeutic option in addition to its IL-1R1-dependent antiinflammatory properties by acting at the intersection of mitochondrial oxidative stress and autophagy with the capacity to restore conditions in which defective proteostasis leads to human disease.
Recent progress in modularly integrated MEMS technologies (2003)

Various approaches to post-CMOS, monolithic integration of MEMS with electronics are described. In particular, recent progress toward a high-performance, low-process-temperature MEMS technology based on polycrystalline silicon-germanium (poly-SiGe) is presented.
Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography (2017)

Our study identified the imaging parameters that determined the repeatability of quantitative retinal vessel density measurements. These findings have implications in determining if OCT-A images can be used to accurately evaluate serial changes in retinal vessel density.