gebhart/patrepeval huggingface dataset:
Prospective Longitudinal Study Evaluating Comprehensive Metabolic and Life Style Characteristics of Pancreas Transplantation Recipients (2021)

Abstract Introduction: Pancreas Transplantation (PT) improves quality of life in Type 1 Diabetes (T1D) patients but limited longitudinal data are available regarding comprehensive metabolic assessment and lifestyle. Our objective was to comprehensively assess T1D patients who underwent PT (PTA and SPK) ≥ 1 year prior on two separate visits 1 year apart. Methodology: We studied 12 PT recipients ≥1 year post PT. Two assessments 1 year apart included comprehensive assessment of graft function using standard mixed meal tolerance test (MMTT), Continuous Glucose Monitoring (CGM) for 1 week, body composition using DEXA scan, physical activity using ActiGraph for 1 week and dietary assessment by VIOCARE®. Results: PT recipients (9F) were 55.5± 9.7 years old, 91.7 % Caucasian with 34.9 ± 12.3 years of diabetes, 6.7 ± 5.2 years (range-1.3–17.6 years) after PT. Ten participants underwent Pancreas Transplantation alone and two received Simultaneous Pancreas Kidney transplantation. Visit 1(V1) showed HbA1c 5.5 ± 0.7%, Fructosamine 238.4 ± 25.6 mcmol/L, BMI 31.2 ± 6.7 kg/m2, fasting plasma glucose (FPG) 95.2 ± 19.4mg/dL and C-peptide 2.6 ± 1.0 ng/ml and visit 2 (V2) HbA1c 5.5 ± 0.6%, Fructosamine 244.4 ± 41.3 mcmol/L, BMI 29.9 ± 5.1kg/m2, FPG 95.4 ± 27.7mg/dL, and C-peptide 2.5 ± 0.8 ng/ml (p-value not significant). One week CGM (n=9) showed excellent glucose control at both visits with mean glucose 117.8 ± 7.0 vs.112 ± 6.2 mg/dl and 96.3 ± 3.6 vs. 96.9±2.8 % time in target range (70-180mg/dl). Time &amp;gt;180mg/dl and &amp;gt;250mg/dl were 2.7 ± 3.0 vs. 1.3±1.7 % (p=0.0413) and 0.2 ± 0.6 vs. 0.1 ± 0.1 % respectively. Mild CGM hypoglycemia (&amp;lt;70 mg/dl) was observed during both visits (1.0 ± 1.0 vs. 1.7± 2 %). CV was 21.1 ± 5.5 and 20.1 ± 4.8 %. Eight recipients underwent MMTT and showed excellent response to Boost® with no significant difference between visits with exception of insulin concentrations at 60 mins (increased from V1) and 90 mins (decreased from V1) (p=0.0424 and 0.0235). DEXA (n=10) revealed similar total % mean fat, and fat distribution in arms, legs and trunk. ActiGraph (n=10) showed similar physical activity during both visits with 16761 ± 5176 and 14499 ± 4192 average steps/day respectively. Mean MET score was 1.6 ± 0.4 and 1.6 ± 0.2 indicating light intensity activity during both periods. Total mean sedentary bouts increased over 1 year (49.6 ± 39.1 vs. 60.8 ± 43.7, p=0.0038). Dietary assessment in 11 recipients showed no significant difference in dietary intake with calories intake 1.3± 0.4 vs. 1.2±0.5 daily Harris-Benedict and macronutrient intake with fat of 36.7 ± 4.3 % and 36.5 ± 5.7 %, CHO of 45.7 ± 5.5 % and 45.7 ± 5.5 % and Omega-3 of 0.1 ± 0.1 g and 0.05 ± 0.1 g respectively. Conclusion: PT recipients have excellent glucose control and pancreas graft function 1 or more years after PT when assessed over successive 2 years with suboptimal body composition and dietary intake and above average physical activity.
American Institute for Manufacturing Integrated Photonics (AIM Photonics) (2015)

The National Network for Manufacturing Innovation (NNMI) is a network of research institutes in the United States that focus on developing and commercializing manufacturing technologies through public-private partnerships between U.S. industry, universities, and federal government agencies. The newest Institute was announced July 27, 2015: The American Institute for Manufacturing Integrated Photonics (AIM Photonics). This Institute is focused on developing an end-to-end photonic integrated circuit (PIC) ecosystem in the U.S., including domestic foundry access, integrated design tools, automated packaging, assembly and test, and workforce development. The Institute will develop and demonstrate innovative manufacturing technologies for: • Ultra-high-speed transmission and switching of signals for the Internet and telecommunications • Microwave photonic PICs • Multi-sensor applications including chem-bio sensors, urban navigation, and other topics
Mathias Brodkorb/Stefan Bruhn, Zeitschriftenporträt: Hier &amp; Jetzt (2011)

Die demokratischen Verfassungsstaaten der Gegenwart sehen sich im Weltmaßstab einer Vielzahl diktatorischer Regime gegenüber. Aber auch innerhalb freiheitlicher Demokratien wirkende extremistische Kräfte und Strömungen liefern den Beweis, dass Prinzipien wie Menschenrechte, Toleranz und politischer Pluralismus keineswegs unangefochten sind.
Reformulating the monitor placement problem (2006)

Confronted with the generalization of monitoring in operational networks, researchers have proposed placement algorithms that can help ISPs deploy their monitoring infrastructure in a cost effective way, while maximizing the benefits of their infrastructure. However, a static placement of monitors cannot be optimal given the short-term and long-term variations in traffic due to re-routing events, anomalies and the normal network evolution. In addition, most ISPs already deploy router embedded monitoring functionalities. Despite some limitations (inherent to being part of a router), these monitoring tools give greater visibility on the network traffic but raise the question on how to configure a network-wide monitoring infrastructure that may contain hundreds of monitoring points.We reformulate the placement problem as follows. Given a network where all links can be monitored, which monitors should be activated and which sampling rate should be set on these monitors in order to achieve a given measurement task with high accuracy and low resource consumption? We provide a formulation of the problem, an optimal algorithm to solve it, and we study its performance on a real backbone network.
WLC09-2: Channel Quality Feedback Schemes for 3GPP's Evolved-UTRA Downlink (2006)

Today's packet-based cellular systems typically are equipped with a channel quality reporting mechanism that supports scheduling and adaptive modulation/coding. When resources are scheduled not only in time but also in frequency the design of the return channel becomes intricate. The feedback signalling must balance improved cell-throughput with deteriorated spectral efficiency in the return link due to excessive signalling. In this contribution we examine system simulation results for the downlink of 3GPP's long-term evolution system equipped with various signalling schemes. The simulations results show that for a certain uplink load in bits/s/Hz, emphasizing the quality of the mobile's best channel instants (assigning these with more signalling bits) provides about 12% higher downlink throughput than capturing the quality of all channel instants equally well. Moreover, about 95% of the throughput provided by an ideal reference feedback scheme is obtained.
Reliability and validity of a single‐item physical activity measure for adolescents (2015)

These findings suggest the single-item measure can provide a reliable and valid assessment of youth physical activity.
Design, Synthesis, and Structure−Activity Relationships of Phthalimide-Phenylpiperazines:  A Novel Series of Potent and Selective α1a-Adrenergic Receptor Antagonists (2000)

Beginning from the screening hit and literature alpha(1)-adrenergic compounds, a hybridized basic skeleton A was proposed as the pharmacophore for potent and selective alpha(1a)-AR antagonists. Introduction of a hydroxy group to increase the flexibility afforded B which served as the screening model and resulted in the identification of the second-generation lead 1. Using the Topliss approach, a number of potent and selective alpha(1a)-AR antagonists were discovered. In all cases, binding affinity and selectivity at the alpha(1a)-AR of S-hydroxy enantiomers were higher than those of the R-hydroxy enantiomers. As compared to the des-hydroxy analogues, the S-hydroxy enantiomers had slightly lower binding affinity at alpha(1a)-AR but gained more than 2-fold selectivity for alpha(1a)-AR over alpha(1b)-AR, and 2- to 6-fold selectivity for alpha(1a)-AR over alpha(1d)-AR. They also had less cross activities against a panel of 25-35 peripheral and CNS receptors. The S-hydroxy enantiomers 23 and 24 (K(i) = 0.29 nM, 0.33 nM; alpha(1b)/alpha(1a) >5690, >6060; alpha(1d)/alpha(1a) = 186, 158, respectively) were slightly less potent but much more selective at alpha(1a)-AR than tamsulosin (K(i) = 0.13 nM, alpha(1b)/alpha(1a) = 14.8, alpha(1d)/alpha(1a) = 1.4). In the functional assay, the S-hydroxy enantiomers 20, 23, and 24 were less potent than tamsulosin in inhibiting contractions of rat prostate tissue but more selective in the inhibition of tissue contractions of rat prostate versus rat aorta. Compound 24 was selected as the development candidate for the treatment of BPH.
Correlation of lesions from multiple images for CAD (2004)

The object of this research is to investigate a method for determining whether two different imaged presentations of a lesion actually represent the same abnormality. Tasks of this kind are expected to arise in numerous applications, including when interpreting multi-view mammograms or multi-modal images for breast cancer diagnosis and when comparing breast images in longitudinal studies for evaluation of disease prognosis or treatment outcome. Currently, we consider the above-stated discrimination task in two-view breast sonography. We are studying image-based feature(s) and are developing general correlation formulation that uses the identified feature(s). By using a database of 262 actual breast lesions we have obtained promising initial results that yield an A<sub>z</sub> value of 0.82 in the task of distinguishing between corresponding lesion pairs and non-corresponding lesion pairs.
Cooperation of the V1/V2 and V3 Domains of Human Immunodeficiency Virus Type 1 gp120 for Interaction with the CXCR4 Receptor (2001)

Human immunodeficiency virus type 1 (HIV-1) entry is triggered by the interaction of the gp120 envelope glycoprotein with a cellular chemokine receptor, either CCR5 or CXCR4. We have identified different mutations in human CXCR4 that prevent efficient infection by one HIV-1 strain (NDK) but not another (LAI) and sought to define these strain-dependent effects at the gp120 level. The lack of activity toward the NDK strain of the HHRH chimeric CXCR4 in which the second extracellular loop (ECL2) derived from the rat CXCR4 and of CXCR4 with mutations at an aspartic acid in ECL2 (D193A and D193R) was apparently due to the sequence of the third variable loop (V3) of gp120, more precisely, to its C-terminal part. Indeed, substitution of the LAI V3 loop or only its C-terminal part in the NDK gp 120 context was sufficient to restore usage of the HHRH, D193A, and D193R receptors. The same result was achieved upon mutation of a single lysine residue of the NDK V3 loop to alanine (K319A) but not to arginine (K319R). These results provide a strong case for a direct interaction between the gp120 V3 loop and the ECL2 domain of CXCR4. By contrast, V3 substitutions had no effect on the inability of NDK to infect cells via a mutant CXCR4 in which the amino-terminal extracellular domain (NT) is deleted. In experiments with a set of chimeric NDK-LAI gp120s, the V1/V2 region from LAI gp120 was both necessary and sufficient for usage of the NT-deleted CXCR4. Different variable domains of gp120 can therefore cooperate for a functional interaction with CXCR4.
A General Model to Predict the Iron Losses in PWM Inverter-Fed Induction Motors (2010)

This paper presents an accurate and efficient method for predicting the iron losses in pulsewidth modulation (PWM) inverter-fed induction motors. The method was initially proposed for the prediction of iron losses in a nonoriented soft magnetic material with the same supply conditions. The proposed method requires the separation of the iron losses in the hysteresis and eddy-current components and the average rectified and rms of the PWM voltage values. Starting from the iron losses measured with a sinusoidal supply and the PWM waveform characteristics, a fast and reliable prediction of the iron losses in the motor with the new voltage supply can be obtained. The proposed method has been proved on an induction-motor prototype capable of providing good accuracy in the iron-loss measurement. The comparison between the measured and predicted iron losses with the PWM supply has shown excellent agreement, confirming the validity of the method.
Elastic Energy Absorption of Origami-Based Corrugations (2017)

The mechanical properties of origami tessellations may provide innovative new designs for energy absorbing applications. The elastic energy absorbing properties of a particular tesselation, the Miura-ori, is investigated. Analytical models for the kinematics and force-deflection of a unit cell based on two different modes of elastic energy absorption are derived. The force-deflection model is developed based on the application of compliant mechanism theory and virtual work analysis. The models are verified through comparison with published results for similar models, analysis using commercial kinematics software and comparison to physical testing. Physical prototypes are used to determine values stiffness terms. The analytical models are used to explore the effects of the key geometrical parameters of the tessellation. This work lays a foundation for the use of origami-based corrugations in elastic energy absorption applications.
Enhancing the Regularization Effect of Weight Pruning in Artificial Neural Networks (2018)

Artificial neural networks (ANNs) may not be worth their computational/memory costs when used in mobile phones or embedded devices. Parameter-pruning algorithms combat these costs, with some algorithms capable of removing over 90% of an ANN's weights without harming the ANN's performance. Removing weights from an ANN is a form of regularization, but existing pruning algorithms do not significantly improve generalization error. We show that pruning ANNs can improve generalization if pruning targets large weights instead of small weights. Applying our pruning algorithm to an ANN leads to a higher image classification accuracy on CIFAR-10 data than applying the popular regularizer dropout. The pruning couples this higher accuracy with an 85% reduction of the ANN's parameter count.
Effect of the novel anti-androgen ARN-509 on response and seizure in castration-resistant prostate cancer models. (2011)

28 Background: ARN-509 is a second-generation anti-androgen discovered in a screen to identify full androgen receptor (AR) antagonists in the context of AR over-expressing prostate cancer cells, a model for castration resistant prostate cancer (CRPC). It has been reported that other second-generation anti-androgens, MDV3100 and BMS-641988, can induce seizures at high dose in pre-clinical species and man and that this is mediated through antagonism of the CNS-based GABA A receptor. To define the clinical potential of ARN-509, we carried out a comprehensive assessment of its in vitro and in vivo activity in validated models of CRPC and assessed its seizure inducing potential. Methods: ARN-509 and MDV3100 were profiled in a series of assays to monitor both on- and off-target activity. Comparative in vivo efficacy in the LNCaP/AR mouse xenograft model of CRPC and pharmacokinetics were determined. Seizure inducing potential was assessed in an acute pentylenetetrazol (PTZ) infusion model. Results: In vivo, in the LNCaP/AR model of CRPC, an ARN-509 dose of 10 mg/kg/day exhibited tumors regressions equivalent in frequency and magnitude to a 30 mg/kg/day dose of MDV3100. Tumor re-growth following once daily dosing (30 mg/kg) for 28 days revealed that ARN-509 treated tumors exhibited a more durable response than MDV3100 treated tumors as evidenced by a significantly longer time to re-growth. At doses that yielded equivalent degree of tumor regression, the steady state plasma and brain levels were significantly lower for ARN-509 (10 mg/kg) than MDV3100 (30 mg/kg). ARN-509 and MDV3100 exhibit similar binding affinity to the GABA A receptor; IC 50 3.0 and 2.7 mM, respectively. In vivo seizure potential of ARN-509 and MDV3100 was assessed in an acute PTZ infusion model in mice. MDV3100 was found to produce a dose dependant lowering of seizure threshold, while ARN-509 had no effect at any dose tested. Conclusions: ARN-509 is a second-generation anti-androgen with significant efficacy and an appropriate safety profile that supports its clinical development in both CRPC and earlier stages of prostate cancer. ARN-509 is currently in a phase I/II study in CRPC patients. [Table: see text]
The web changes everything (2009)

The Web is a dynamic, ever changing collection of information. This paper explores changes in Web content by analyzing a crawl of 55,000 Web pages, selected to represent different user visitation patterns. Although change over long intervals has been explored on random (and potentially unvisited) samples of Web pages, little is known about the nature of finer grained changes to pages that are actively consumed by users, such as those in our sample. We describe algorithms, analyses, and models for characterizing changes in Web content, focusing on both time (by using hourly and sub-hourly crawls) and structure (by looking at page-, DOM-, and term-level changes). Change rates are higher in our behavior-based sample than found in previous work on randomly sampled pages, with a large portion of pages changing more than hourly. Detailed content and structure analyses identify stable and dynamic content within each page. The understanding of Web change we develop in this paper has implications for tools designed to help people interact with dynamic Web content, such as search engines, advertising, and Web browsers.
ergm.graphlets: A Package for ERG Modeling Based on Graphlet Statistics (2015)

Exponential-family random graph models are probabilistic network models that are parametrized by sufficient statistics based on structural (i.e., graph-theoretic) properties. The ergm package for the R statistical computing environment is a collection of tools for the analysis of network data within an exponential-family random graph model framework. Many different network properties can be employed as sufficient statistics for exponential- family random graph models by using the model terms defined in the ergm package; this functionality can be expanded by the creation of packages that code for additional network statistics. Here, our focus is on the addition of statistics based on graphlets. Graphlets are classes of small, connected, induced subgraphs that can be used to describe the topological structure of a network. We introduce an R package called ergm.graphlets that enables the use of graphlet properties of a network within the ergm package of R. The ergm.graphlets package provides a complete list of model terms that allows to incorporate statistics of any 2-, 3-, 4- and 5-node graphlets into exponential-family random graph models. The new model terms of the ergm.graphlets package enable both exponential-family random graph modeling of global structural properties and investigation of relationships between node attributes (i.e., covariates) and local topologies around nodes.
Privacy-Aware Data-Lifetime Control NAND Flash System for Right to be Forgotten with In-3D Vertical Cell Processing (2019)

This paper proposes Privacy-aware Data-Lifetime Control NAND Flash System (PDLCS), which changes the data-lifetime flexibly for the right to be forgotten. This system realizes both short and long term data-lifetime by In-3D Vertical Cell Processing. Furthermore, data-lifetime can be extended or shortened at any time. This system secures privacy data and thus is a universal solution for future secure storage, which is not resolved by software techniques.
Template synthesis of single-phase δ3-MoN superconducting nanowires (2013)

We demonstrate a new and effective method of producing single-phase superconducting δ3-MoN nanowires from bundled Mo6SyIz (8.2 ≤ y + z ≤ 10) nanowire templates in the presence of ammonia gas. Magnetic susceptibility and electrical resistance measurements confirm single-phase material synthesis. Measurements of four-contact resistance on single wires with diameters above 100 nm in a magnetic field are used to determine the critical field, while diameter dependence and magnetization measurements are used to investigate the homogeneity of the nanowires.
Reliable BIER With Peer Caching (2019)

BIER (Bit-Indexed Explicit Replication) alleviates the operational complexities of multicast protocols (associated to the multicast tree and the incurred state in intermediate routers), by allowing for source-driven, per-packet destination selection, efficient encoding thereof in packet headers, and stateless forwarding along shortest-path multicast trees. BIER per-packet destination selection enables efficient reliable multicast delivery: packets not received by a subset of intended destinations can be efficiently BIER-retransmitted to only that subset. While BIER-based reliable multicast exhibits attractive performance attributes, relying on source retransmissions for packet recovery may be costly - even unnecessary, if topologically close peers are able to provide a copy of the packet. Thus, this paper extends the use of reliable BIER multicast to allow recovery also from peers, using Segment Routing (SR) to steer retransmission requests through a set of potential (local) candidates, before requesting retransmissions from the source as a last resort only. A general framework is introduced, which can accommodate different policies for the selection of candidate peers for retransmissions. Simple (both static and adaptive) policies are introduced and analyzed, both (i) theoretically and (ii) by way of simulations in data-center-like and real-world topologies. Results indicate that local peer recovery is able to substantially reduce the overall retransmission traffic, and that this can be achieved through simple policies, where no signalling is required to build a set of candidate peers.
ChemInform Abstract: ARENE TRANSITION‐METAL CHEMISTRY. 5. ARENE LIGAND EXCHANGE AND REACTIVITY IN η6‐ARENE IRIDIUM(I) COMPLEXES (1981)

Abstract Die n6‐Aren‐Ir(I)‐Komplexe (Ia‐e) werden nach verschiedenen Methoden dargestellt, wobei die Synthesen aus dimerem Chlorocyclooctadien‐(l,5)‐lr, Ag(I)‐Salz und Arenen in Aceton/Dichlormethan oder aus Acetylacetonato‐cyclooctadien‐(1,5)=‐Ir(I), Tritylfluoroborat und Arenen dominieren.
A Rapid and Efficient Luminescence-based Method for Assaying Phosphoglycosyltransferase Enzymes (2016)

Phosphoglycosyltransferases (PGTs) are families of integral membrane proteins with intriguingly diverse architectures. These enzymes function to initiate many important biosynthetic pathways including those leading to peptidoglycan, N-linked glycoproteins and lipopolysaccharide O-antigen. In spite of tremendous efforts, characterization of these enzymes remains a challenge not only due to the inherent difficulties associated with the purification of integral membrane proteins but also due to the limited availability of convenient assays. Current PGT assays include radioactivity-based methods, which rely on liquid-liquid or solid-liquid extractions, multienzyme systems linked to lactate dehydrogenase and NAD+ generation, and HPLC-based approaches, all of which may suffer from low sensitivity and low throughput. Herein, we present the validation of a new luminescence-based assay (UMP-Glo) for measuring activities of PGT enzymes. This assay measures UMP, the by-product of PGT reactions, in a sensitive and quantitative manner by measuring the luminescence output in a discontinuous coupled assay system. The assay is rapid and robust in nature, and also compatible with microtiter plate formats. Activity and kinetic parameters of PglC, a PGT from Campylobacter jejuni, were quickly established using this assay. The efficacy of the assay was further corroborated using two different PGTs; PglC from Helicobacter pullorum and WecA from Thermatoga maritima.