gebhart/patrepeval huggingface dataset:
Optimal design of resonant converter for Electrostatic Precipitators (2010)

This work presents a design optimization procedure for Series Parallel Resonant Converters (LCC) employed in Electrostatic Precipitator (ESP) power supplies. The system parameters, such as resonant tank elements, are selected in order to reduce semiconductor losses when a typical ESP energization operation range is considered. Here, the sum of the power losses of the switches are predicted for a set of parameters by mathematical models of the LCC resonant converter, and also by loss characteristics of suitable commercially available IGBTs obtained from experimental analysis and datasheet values. The analysis comprises two different control strategies: the conventional Variable Frequency (VF) control and the Dual Control (DC). Finally, the circuit operation and design are verified with a 60kW charging capability LCC resonant converter test set-up. Both control strategies are analyzed by comparing semiconductor's losses for five commercial modules.
Model development methodology for localized corrosion of copper (2023)

A 2-D axisymmetric time-dependent model for the corrosion of copper under an Evans droplet was developed using the finite-element method. Some unique features of the model are inclusion of 6 heterogeneous and 15 homogeneous reactions, implicit calculation of nm-scale films, and treatment of the influence of films on surface concentrations and potentials. Cathodic and anodic regions are not pre-defined on the electrode surface but are determined by values of local concentrations and potentials. The model shows time-dependent radial distributions for current density and surface coverage of films. The present work describes the methodology for the development of this mechanistic model.
Oxidation of Biological Thiols:Glutathione-Indophenol Interactions* (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of Biological Thiols:Glutathione-Indophenol Interactions*Donald S. Coffey and Leslie HellermanCite this: Biochemistry 1964, 3, 3, 394–402Publication Date (Print):March 1, 1964Publication History Published online1 May 2002Published inissue 1 March 1964https://pubs.acs.org/doi/10.1021/bi00891a015https://doi.org/10.1021/bi00891a015research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ultra-low-loss Waveguide Crossing Arrays Based on Imaginary Coupling of Multimode Bloch Waves (2013)

We experimentally demonstrate ultra-low-loss waveguide crossing arrays showing loss down to 0.04dB/crossing. They rely on a low loss, focusing Bloch wave that is stabilized by radiative scattering, via a radiative form of coupling.
Characterization and Modeling of Wideband Wireless Transceivers (2007)

In this paper, we proposed a practical approach to accurately characterize a 3G wideband wireless transceiver, which will exhibit strong memory effects. The memory effects can be easily identified by accurate evaluation and alignment of the time delay between the input and output of the transceiver. Using the extracted transceiver characteristic data, a memory polynomial model is constructed to mimic the dynamic properties of the transceiver. The experimental validation results, which are obtained with a transceiver prototype based on an L-band 60- Watt GaAs FET push-pull amplifier, a vector signal generator, a spectrum analyzer and a vector signal analyzer, demonstrate the effectiveness of the transceiver characterization approach and the accuracy of the dynamic nonlinear models discussed.
Novel desiccants based on designed polymeric blends (2001)

We describe a novel concept for the preparation of desiccants based on polymeric blends. A hydrophilic channeling agent (e.g., PEG) is blended with a hydrophobic polymer (e.g., polypropylene) to produce interconnecting hydrophilic channels within the hydrophobic polymer. To make the system desiccating, a water-absorbing material is blended into the polymeric matrix to become distributed within the hydrophilic portion. The resultant blend may be molded and cast into plug-type inserts and liners for closed containers, or formed into films, sheets, beads, or pellets; its uses include pharmaceutical and industrial applications. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 80: 317–327, 2001
Total skin electron beam therapy followed by adjuvant psoralen/ultraviolet-A light in the management of patients with T1 and T2 cutaneous T-cell lymphoma (mycosis fungoides) (1997)

PUVA can maintain remissions in patients with CTCL after TSEBT. There is a significant benefit in DFS but no statistically significant improvement in OS. Prospective, randomized data are needed to confirm these results. PUVA is also effective as a salvage therapy after TSEBT in early-stage patients with recurrence, with acceptable toxicity.
Rear view camera system for car driving assistance (2012)

The paper presents a system-on-chip (SOC) aimed to provide the fast video stream processing and wireless transfer for automotive applications, e.g. from a truck's trailer to the driver cabin. This SOC is based on the ARC processor and a custom very-low-latency video codec. It is verified and implemented in FPGA on a custom printed-circuit-board. The very first test results are presented too.
Caveolin expression is decreased following androgen deprivation in human prostate cancer cell lines (1999)

Unlike the mouse reconstitution model of prostate cancer, the pattern of caveolin expression in benign prostatic epithelium and androgen-sensitive human prostate cancer is consistent with tumor suppressive activity.
Relationship between levels of secreted phospholipase A2 groups IIA and X in the airways and asthma severity (2011)

Background Secreted phospholipase A(2) (sPLA(2) ) may be important mediators of asthma, but the specific sPLA(2) s involved in asthma are not known. Objective To evaluate sPLA(2) group IIA, V, and X proteins (sPLA(2) -IIA, sPLA(2) -V, and sPLA(2) -X) in bronchoalveolar lavage (BAL) fluid, BAL cells, and airway epithelial cells of subjects with and without asthma, and examine the relationship between the levels of specific sPLA(2) enzymes and airway inflammation, asthma severity, and lung function. Methods The expression of sPLA(2) -IIA, sPLA(2) -V, and sPLA(2) -X in BAL cells and epithelial brushings was assessed by qPCR. The levels of these sPLA(2) proteins and sPLA(2) activity with and without group II and group X-specific inhibitors were measured in BAL fluid from 18 controls and 39 asthmatics. Results The airway epithelium expressed sPLA(2) -X at higher levels than either sPLA(2) -IIA or sPLA(2) -V, whereas BAL cells expressed sPLA(2) -IIA and sPLA(2) -X at similar levels. The majority of sPLA(2) activity in BAL fluid was attributed to either sPLA(2) -IIA or sPLA(2) -X. After 10-fold concentration of BAL fluid, the levels of sPLA(2) -X normalized to total protein were increased in asthma and were associated with lung function, the concentration of induced sputum neutrophils, and prostaglandin E(2) . The levels of sPLA(2) -IIA were elevated in asthma when normalized to total protein, but were not related to lung function, markers of airway inflammation or eicosanoid formation. Conclusions and Clinical Relevance These data indicate that sPLA(2) -IIA and sPLA(2) -X are the major sPLA(2) s in human airways, and suggest a link between the levels of sPLA(2) -X in the airways and several features of asthma.
Synthesis, structures and properties of benzoporphycenes and naphthoporphycenes (2011)

A series of benzoporphycenes and naphthoporphycenes and their zinc complexes were prepared from bicyclo[2.2.2]octadiene fused porphycenes by a retro-Diels-Alder reaction and their photophysical properties were studied. Free-base tetranaphthoporphycene was not soluble in common organic solvents, but zinc tetranaphthoporphycene was slightly soluble in pyridine and showed B- and Q-bands at 507 and 690 nm, respectively. Dinaphthoporphycene showed broad B- and Q-bands due to its lower symmetry. Tetrabenzo-, dibenzo-, and dinaphthoporphycenes showed fluorescence at 673, 654, and 670 nm with quantum yields of 0.32, 0.42, and 0.31, respectively, although their precursors were non-fluorescent. Zinc complexes of tetrabenzo-, dibenzo-, tetranaphtho-, dinaphthoporphycenes and their bicyclo[2.2.2]octadiene-fused precursors revealed moderate fluorescence with quantum yields of 0.15–0.37. The crystal structures of tetrabenzo- and dibenzoporphycenes showed herringbone structures, while the zinc tetrabenzoporphycene showed a hexagonal box-structure with six pyridine ligands inside.
The influence of annealing on thermal transitions in a nematic copolyester (1999)

Thermal transitions of a glassy, main chain, liquid crystalline, random copolyester, HIQ-40, have been characterized. HIQ-40 is made from 40 mol percent p-hydroxybenzoic acid (HBA) and 30 mol % each of p-hydroquinone (HQ) and isophthalic acid (IA). This polymer is soluble in organic solvents, permitting the preparation of thin, solution-cast films that are in a glassy, metastable, optically isotropic state. On first heating of an isotropic HIQ-40 film in a calorimeter, one glass transition is observed at low temperature (approximately 42°C), and is ascribed to the glass/rubber transition of the isotropic polymer. A cold crystallization exotherm centered near 150°C is observed. This is associated with the development of low levels of crystalline order. A broad melting endotherm is centered at about 310°C; this endotherm marks the melting of crystallites and the transformation to a nematic fluid. A nematic to isotropic transition was not observed by calorimetry. After quenching from the nematic melt, a Tg is observed in the range of 110–115°C and is associated with the glass/rubber transition of the nematically ordered polymer. Annealing optically isotropic films at temperatures above the isotropic glass transition results in the systematic development of axial order. In these annealed samples, Tg increases rapidly until it is near the annealing temperature, then Tg increases more slowly at longer annealing times. In as-cast films annealed at 120–135°C, the light intensity transmitted through a sample held between crossed polarizers in an optical microscope (a qualitative measure of birefringence and, in turn, axial order) initially increases rapidly and uniformly throughout the sample and, at longer annealing times, approaches asymptotic values that are higher at higher annealing temperatures. The increase in transmitted intensity is ascribed to the development of axial order. The uniform increase in transmitted intensity suggests that ordering occurs by a rather global process and not via a nucleation and growth mechanism. © 1999 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 37: 505–522, 1999
Speed binning aware design methodology to improve profit under parameter variations (2006)

Designing high-performance systems with high yield under parameter variations has raised serious design challenges in nanometer technologies. In this paper, we propose a profit-aware yield model, based on which we present a statistical design methodology to improve profit of a design considering frequency binning and product price profile. A low-complexity sensitivity-based gate sizing algorithm is developed to improve the profitability of design over an initial yield-optimized design. We also propose an algorithm to determine optimal bin boundaries for maximizing profit with frequency binning. Finally, we present an integrated design methodology for simultaneous sizing and bin placement to enhance profit under an area constraint. Experiments on a set of ISCAS85 benchmarks show up to 26% (36%) improvement in profit for fixed bin (for simultaneous sizing and bin placement) with three frequency bins considering both leakage and delay bounds compared to a design optimized for 90% yield at iso-area.
Lepidopteran-Active Variable-Region Sequence Imparts Coleopteran Activity in eCry3.1Ab, an Engineered Bacillus thuringiensis Hybrid Insecticidal Protein (2010)

A unique, coleopteran-active protein, termed eCry3.1Ab, was generated following variable-region exchange of a Bacillus thuringiensis lepidopteran-active protein, Cry1Ab, with a Cry3A region. Our results support the hypothesis that this variable-region exchange is responsible for imparting strong bioactivity against the larvae of western corn rootworm (WCR) (Diabrotica virgifera virgifera LeConte), a pest species which is not susceptible to either parent protein sequence. This study demonstrates the potential of successfully engineering a portion(s) of a lepidopteran-active B. thuringiensis sequence so that it has activity against coleopterans. Further elucidation of the eCry3.1Ab activity indicated the importance of variable regions 4 to 6 that were derived from Cry1Ab instead of Cry1Ac. There was some flexibility in making domain III of engineered hybrid insecticidal proteins even more Cry1Ab-like and retaining activity, while there was less flexibility in making domain III more Cry3A-like and retaining activity. In vitro binding studies with brush border membrane vesicles demonstrated that there was specific binding of chymotrypsin-processed modified Cry3A (mCry3A), which was not diminished by addition of a 100-fold molar excess of chymotrypsin-processed eCry3.1Ab or unprocessed eCry3.1Ab. In addition, in the converse experiment, specific binding of chymotrypsin-processed eCry3.1Ab was not diminished by the presence of a 75-fold molar excess of chymotrypsin-processed mCry3A. These data support the hypothesis that eCry3.1Ab can interact with different binding sites than the activated form of mCry3A in the WCR brush border and may provide a different mode of action from the standpoint of resistance management.
Tracking Microbial Contamination in Retail Environments Using Fluorescent Powder - A Retail Delicatessen Environment Example (2014)

Cross contamination of foodborne pathogens in the retail environment is a significant public health issue contributing to an increased risk for foodborne illness. Ready-to-eat (RTE) processed foods such as deli meats, cheese, and in some cases fresh produce, have been involved in foodborne disease outbreaks due to contamination with pathogens such as Listeria monocytogenes. With respect to L. monocytogenes, deli slicers are often the main source of cross contamination. The goal of this study was to use a fluorescent compound to simulate bacterial contamination and track this contamination in a retail setting. A mock deli kitchen was designed to simulate the retail environment. Deli meat was inoculated with the fluorescent compound and volunteers were recruited to complete a set of tasks similar to those expected of a food retail employee. The volunteers were instructed to slice, package, and store the meat in a deli refrigerator. The potential cross contamination was tracked in the mock retail environment by swabbing specific areas and measuring the optical density of the swabbed area with a spectrophotometer. The results indicated that the refrigerator (i.e. deli case) grip and various areas on the slicer had the highest risk for cross contamination. The results of this study may be used to develop more focused training material for retail employees. In addition, similar methodologies could also be used to track microbial contamination in food production environments (e.g. small farms), hospitals, nursing homes, cruise ships, and hotels.
Effects of CD2 locus control region sequences on gene expression by retroviral and lentiviral vectors (2001)

Locus control region (LCR) sequences are involved in the establishment of open chromosomal domains. To evaluate the possibility of exploiting the human CD2 LCR to regulate gene expression by Moloney murine leukemia virus (Mo-MLV)-based retroviral vectors in T cells, it was included in vectors carrying the enhanced green fluorescence protein (EGFP) reporter gene; then transduction in vitro of lymphoid and nonlymphoid cell lines was performed. Deletion of the viral enhancer in the Mo-MLV long terminal repeat was necessary to detect LCR activity in the context of these retroviral vectors. It was found that a full-length (2.1 kb), but not a truncated (1.0 kb), CD2 LCR retained the ability to modulate reporter gene expression by Mo-MLV-derived retroviral vectors, leading to a homogeneous, unimodal pattern of EGFP expression that remained unmodified in culture over time, specifically in T-cell lines; on the other hand, viral titer was strongly reduced compared with vectors not carrying the LCR. Lentiviral vectors containing the CD2 LCR could be generated at higher titers and were used to analyze its effects on gene expression in primary T cells. Subcutaneous implantation of genetically modified cells in immunodeficient mice showed that retroviral vectors carrying the CD2 LCR conferred an advantage in terms of transgene expression in vivo, compared with the parental vector, by preventing the down-modulation of EGFP expression. These findings suggest a potential application of this LCR to increase gene expression by retroviral and lentiviral vectors in T lymphocytes.
Bioactive Natural, Biocatalytic, and Semisynthetic Tobacco Cembranoids (2010)

The two major Nicotiana tabacum tobacco cembranoids, (1 S,2 E,4 R,6 R,7 E,11 E)-2,7,11-cembratriene-4,6-diol (1) and its C-4 epimer, exhibit a wide range of interesting biological activities. Although the tumorigenesis inhibition activity of tobacco cembranoids have been known since the mid 1980's, only a limited number of investigations have targeted their optimization and structure-activity relationship. This study reports the isolation of the new (1 S,2 E,4 S,6 E,8 S,11 E)-2,6,11-cembratriene-8- O-methyl-4,8-diol (3) and the known (1 S,2 E,4 R,6 R,7 E,11 E)-2,7,11-cembratriene-4- O-methyl-4,6-diol (2) from fresh N. tabacum leaves. Cembranoid 2 showed good anti-migratory activity against prostate cancer cell lines, and was therefore subjected to microbial transformation and semisynthetic optimization studies. Biotransformation of 2 using the fungal strains Cunninghamella NRRL 5695 and Mucor ramannianus ATCC 9628 afforded new ( 4 and 5) and known ( 6 and 7) metabolites. Semisynthetic esterification, oxidation, epoxidation, and reaction with Lawesson's reagent afforded the new products 8- 14. Cembranoid 2 and its epoxidation product 9 showed potent anti-migratory activities against the highly metastatic human prostate cancer cell lines PC-3M-CT+ (spheroid disaggregation assay) and PC-3 (wound-healing assay).
Evaluation and discussion of disturbance observer‐based anti‐slip/skip readhesion control for electric train (2009)

Abstract The improvement of adhesion characteristics is very important for electric trains. The drive system of electric trains must have fine anti‐slip and anti‐skid readhesion controls. In order to achieve the required adhesion, we have already proposed an anti‐slip/skid readhesion control system based on disturbance observer and sensorless vector control. Moreover, we have already applied the proposed method to actual electric multiple unit trains Series 205‐5000. In this paper, using the experimental results of Series 205‐5000 and the numerical simulation results, we evaluate the proposed anti‐slip/skid readhesion control system and confirm that the system has the desired driving wheel torque response. © 2009 Wiley Periodicals, Inc. Electr Eng Jpn, 169(4): 55–64, 2009; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20834
Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)-s-triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades (2022)

Here, we synthesized a newseries of <i>mono</i>- and <i>bis</i>(dimethylpyrazolyl)-<i>s</i>-triazine derivatives. The synthetic methodology involved the reaction of different mono- and dihydrazinyl-<i>s</i>-triazine derivatives with acetylacetone in the presence of triethylamine to produce the corresponding target products in high yield and purity. The antiproliferative activity of the novel <i>mono</i>- and <i>bis</i>(dimethylpyrazolyl)-<i>s</i>-triazine derivatives was studied against three cancer cell lines, namely, MCF-7, HCT-116, and HepG2. <i>N</i>-(4-Bromophenyl)-4-(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-amine <b>4f</b>, <i>N</i>-(4-chlorophenyl)-4,6-bis(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-1,3,5-triazin-2-amine <b>5c</b>, and 4,6-<i>bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-<i>N</i>-(4-methoxyphenyl)-1,3,5-triazin-2-amine <b>5d</b> showed promising activity against these cancer cells: <b>4f</b> [(IC<sub>50</sub> = 4.53 ± 0.30 μM (MCF-7); 0.50 ± 0.080 μM (HCT-116); and 3.01 ± 0.49 μM (HepG2)]; <b>5d</b> [(IC<sub>50</sub> = 3.66 ± 0.96 μM (HCT-116); and 5.42 ± 0.82 μM (HepG2)]; and <b>5c</b> [(IC<sub>50</sub> = 2.29 ± 0.92 μM (MCF-7)]. Molecular docking studies revealed good binding affinity with the receptor targeting EGFR/PI3K/AKT/mTOR signaling cascades. Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC<sub>50</sub> value of 61 nM compared to that of Tamoxifen (IC<sub>50</sub> value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. Interestingly, <b>4f</b> showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, respectively). Hence, the synthetic 1,3,5-triazine derivative <b>4f</b> exhibited promising antiproliferative activity in HCT-116 cells through apoptosis induction by targeting the EGFR and its downstream pathway.
Synthesis with Single Macromolecules: Covalent Connection between a Neutral Dendronized Polymer and Polyelectrolyte Chains as well as Graphene Edges (2009)

Single chains of a neutral, dendronized polymer with peripheral azide groups (PG3A) are co-deposited onto molecularly modified graphite substrates with a positively charged dendronized polymer (PG2) as well as with negatively charged plasmid dsDNA. PG3A is also prepared near graphite step-edges. Single PG3A chains are moved with a scanning force microscope tip, into close contact with either of the two polyelectrolytes, as well as the step-edge at predetermined positions. Treating these structures in situ with UV light leads to photochemically induced cross-linking between the PG3A chains carrying azide groups and PG2, dsDNA, and graphite step-edges, respectively, which is proven by mechanically challenging the "welding" points by pulling on the molecules with the SFM-tip.