gebhart/patrepeval huggingface dataset:
Progressive loss of conserved spike protein neutralizing antibody sites in Omicron sublineages is balanced by preserved T-cell recognition epitopes (2022)

Abstract The continued evolution of the SARS-CoV-2 Omicron variant has led to the emergence of numerous sublineages with different patterns of evasion from neutralizing antibodies. We investigated neutralizing activity in immune sera from individuals vaccinated with SARS-CoV-2 wild-type spike (S) glycoprotein-based COVID-19 mRNA vaccines after subsequent breakthrough infection with Omicron BA.1, BA.2, or BA.4/BA.5 to study antibody responses against sublineages of high relevance. We report that exposure of vaccinated individuals to infections with Omicron sublineages, and especially with BA.4/BA.5, results in a boost of Omicron BA.4.6, BF.7, BQ.1.1, and BA.2.75 neutralization, but does not efficiently boost neutralization of sublineages BA.2.75.2 and XBB. Accordingly, we found in in silico analyses that with occurrence of the Omicron lineage a large portion of neutralizing B-cell epitopes were lost, and that in Omicron BA.2.75.2 and XBB less than 12% of the wild-type strain epitopes are conserved. In contrast, HLA class I and class II presented T-cell epitopes in the S glycoprotein were highly conserved across the entire evolution of SARS-CoV-2 including Alpha, Beta, and Delta and Omicron sublineages, suggesting that CD8 + and CD4 + T-cell recognition of Omicron BQ.1.1, BA.2.75.2, and XBB may be largely intact. Our study suggests that while some Omicron sublineages effectively evade B-cell immunity by altering neutralizing antibody epitopes, S protein-specific T-cell immunity, due to the very nature of the polymorphic cell-mediated immune, response is likely to remain unimpacted and may continue to contribute to prevention or limitation of severe COVID-19 manifestation.
Oxide-Semiconductor Materials for Quantum Computation (2002)

Scalable fault-tolerant quantum computer architectures require quantum gates that operate within a small fraction of the qubit decoherence time and with high accuracy over a bandwidth set by the decoherence rate. Electron spin quantum bits in Si are promising because of long decoherence times (∼0.5 ms), but electrical gating schemes still seem problematic. Oxide–semiconductor heterostructures have the potential for precise electrical control of gate operations in the semiconductor, using optical rectification in the ferroelectric oxide. Accurate (∼80 dB), local (∼10 nm), dynamic (>THz) and programmable optical control over electric polarization in the ferroelectric can be achieved using existing technology. Optical techniques may also be useful in rapid initialization of the quantum computer, and for providing a source of initialized qubits to use for quantum error correction. Advantages of optical methods will be discussed within a framework proposed for a quantum information processor using ferroelectrically coupled electron spins and Ge quantum dots in Si.
/spl Oscr/n dielectric properties of glass-bead filled polymer composite systems (2002)

Analysis of the data obtained have shown that the master-curve procedure could not be satisfactorily applied for both considered systems of polymer glassbead mixtures. We, therefore, could not conclude much about the temperature dependences and activation energies of the processes involved. On the other hand, the effect of glass-bead size and its electrical properties were significant. The samples with large glass-bead had two RPS whose dielectric strengths increased with the concentration of the glass-beads. The behavior of losses has also indicated the influence of the high conductivity of the large glass-beads.
Synthesis of Transesterified Palm Olein‐Based Polyol and Rigid Polyurethanes from this Polyol (2015)

Transesterification of palm olein with glycerol can increase the functionality by introducing additional hydroxyl groups to the triglyceride structure, an advantage compared to using palm olein directly as feedstock for producing palm-based polyol. The objective of this study was to synthesize transesterified palm olein-based polyol via a three-step reaction: (1) transesterification of palm olein, (2) epoxidation and (3) epoxide ring opening. Transesterification of palm olein yielded approximately 78 % monoglyceride and has an hydroxyl value of approximately 164 mg KOH g<sup>-1</sup>. The effect of formic acid and hydrogen peroxide concentrations on the epoxidation reaction was studied. The relationships between epoxide ring-opening reaction time and residual oxirane oxygen content and hydroxyl value were monitored. The synthesized transesterified palm olein-based polyol has hydroxyl value between 300 and 330 mg KOH g<sup>-1</sup> and average molecular weight between 1,000 and 1,100 Da. On the basis of the hydroxyl value and average molecular weight of the polyol, the transesterified palm olein-based polyol is suitable for producing rigid polyurethane foam, which can be designed to exhibit desirable properties. Rigid polyurethane foams were synthesized by substituting a portion of petroleum-based polyol with the transesterified palm olein-based polyol. It was observed that by increasing the amount of transesterified palm olein-based polyol, the core density and compressive strength were reduced but at the same time the insulation properties of the rigid polyurethane foam were improved.
J uggler (2016)

We present Juggler, a practical reordering resilient network stack for datacenters that enables any packet to be sent on any path at any level of priority. Juggler adds functionality to the Generic Receive Offload layer at the entry of the network stack to put packets in order in a best-effort fashion. Juggler's design exploits the small packet delays in datacenter networks and the inherent burstiness of traffic to eliminate the negative effects of packet reordering almost entirely while keeping state for only a small number of flows at any given time. Extensive testbed experiments at 10Gb/s and 40Gb/s speeds show that Juggler is effective and lightweight: it prevents performance loss even with severe packet reordering while imposing low CPU overhead. We demonstrate the use of Juggler for per-packet multi-path load balancing and a novel system that provides bandwidth guarantees by dynamically prioritizing packets.
The Chromosome-Scale Genome Resource for Two Endophytic Fusarium species, F. culmorum and F. pseudograminearum (2021)

Genus <i>Fusarium</i> (Ascomycota, Hypocreales, Nectriaceae) includes many economically important plant pathogens that cause devastating diseases of a wide range of crops and trees. Interestingly, there is increasing evidence that some <i>Fusarium</i> species also live as endophytes and benefit plant growth and stress tolerance. In this work, we sequence the whole genomes of endophytic <i>F. culmorum</i> and <i>F. pseudograminearum</i>, isolated from a coastal dunegrass (<i>Leymus mollis</i>), using long-read single-molecule real-time sequencing technology. Their genomes are assembled into four chromosomes and a mitochondrial genome with a total assembly size of 40.05 and 42.90 M, respectively. This resource should not only facilitate functional studies designed to better understand what makes the two <i>Fusarium</i> species such successful plant-beneficial fungi but should also reveal their genome evolution and adaptation.[Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license.
On Regular Resource Grid for Filtered OFDM (2016)

Filtered orthogonal frequency division multiplexing (F-OFDM) can accommodate diverse service requirements by introducing additional filtering to OFDM and flexibly adapting the filter according to the service requirement. However, when block filtering is flexibly adapted per-subband, the regular resource grid could be violated. In this letter, we propose a solution to maintain the regular resource grid for F-OFDM. The proposed solution is twofold: 1) it allocates guard bands inside the filter bandwidth, which is kept independent of guard band and 2) it introduces timing advance according to the filter used. It is shown in practically relevant scenarios that the proposed solution, despite its simplicity, performs better than another more complex approach.
Dual-core fiber amplifier for separation of thermal and nonlinear effects (2023)

A dual-core waveguide architecture provides two evanescently coupled waveguides where a first waveguide is doped with an active gain species to produce optical power and a second waveguide that runs parallel to the first waveguide is configured to collect the power produced by the first waveguide. Power is harvested from the second waveguide.
AdKDD 2021 (2021)

The digital advertising field has always had challenging ML problems, learning from petabytes of data that is highly imbalanced, reactivity times in the milliseconds and more recently compounded with the complex user's path to purchase across devices, across platforms and even online/real-world behavior. The AdKDD workshop continues to be a forum for researchers in advertising, during and after KDD. Our website which hosts slides and abstracts receives approximately 2,000 monthly visits. In surveys during AdKDD 2019 and 2020, over 60% agreed that AdKDD is the reason they attended KDD and over 90% indicated they would attend next year. The 2021 edition is particularly timely because of ongoing developments in ad tracking. We will aim to discuss notions of privacy and tracking enforced by GDPR and through company policies. In addition, we will seek papers that discuss fairness in the context of advertising, to what extent does hyper-personalization work, and on whether the ad industry as a whole needs to think through more effective business models such as incrementality. Ad tech is in an interesting place of evolution/maturity now and we would like to use the AdKDD forum to get the researchers to think not only about the ML aspects but also spark conversations about the societal ones.
An Affine Projection Algorithm for the Identification of Impulse Responses with Symmetric/Antisymmetric Characteristics (2022)

This paper aims to present an affine projection algorithm (APA) tailored for the identification of system impulse responses with intrinsic symmetric/antisymmetric characteristics. Such an algorithm uses a combination, based on the Kronecker product decomposition, of two (short length) adaptive filters to efficiently estimate a long length system impulse response. As a result of that, the proposed algorithm outperforms the conventional APA in terms of convergence speed and tracking ca-pabilities. Simulation results are shown and discussed, confirming the improved performance achieved by the proposed algorithm in several operating conditions.
A cascade add/drop transceiver structure to solve the optical beat interference problem in subcarrier-multiplexed passive optical networks (2000)

A cascade add/drop transceiver (CAT) structure in a star-ring architecture for subcarrier-multiplexed passive optical networks (SCM–PONs) is demonstrated to overcome the optical beat interference (OBI) problem. The proposed CAT structure is a simple, reliable, and feasible approach for SCM–PONs. Our experimental results reveal that the CAT structure in a ring can completely eliminate the OBI problem, and maintain a good transmission quality. © 2000 John Wiley & Sons, Inc. Microwave Opt Technol Lett 25: 1–4, 2000.
Bortezomib Treatment Sensitizes Oncolytic HSV-1–Treated Tumors to NK Cell Immunotherapy (2016)

This study provides a significant rationale for triple combination therapy with bortezomib, oHSV, and NK cells to improve efficacy, in glioblastoma patients. Clin Cancer Res; 22(21); 5265-76. ©2016 AACRSee related commentary by Suryadevara et al., p. 5164.
New Naphthoquinone Derivatives from the Ascomycete IBWF79B-90A (2009)

Bioactivity-guided fractionation of extracts from the fungus IBWF79B-90A resulted in the isolation of three known naphthoquinones, herbarin, dehydroherbarin, and O-methylherbarin and the azaanthraquinone scorpinone as well as three structurally related derivatives, O-phenethylherbarin and herbaridines A and B. All seven compounds exhibited cytotoxic activities against several cell lines.
Metabolic Syndrome as a Cardiovascular Risk Factor: A Reality or Just a Multiplex of Risk Factors? A Study on Association Between Endothelial Dysfunction And Metabolic Syndrome as a Cardiovascular Risk Factor (2023)

Background:Metabolic syndrome is a constellation of various cardiovascular risk factors with a potential to double the risk of coronary artery disease. However, in real world scenario, this is just a combination of multiple CV risk factors and its separate existence is somehow regarded as a myth in endothelial function assessment. Endothelial dysfunction is regarded as a precursor and a surrogate marker of atherosclerosis and coronary artery disease. Therefore a study was designed to evaluate the role of metabolic syndrome as a cardiovascular risk factor by assessing endothelial function in subjects with it. Methods: One hundred subjects with various cardiovascular risk factors were selected and endothelial dysfunction was assessed by measuring flow-mediated dilation of brachial artery. The rates of endothelial dysfunction was compared between subjects with and without metabolic syndrome. Similarly the rates of metabolic syndrome was calculated in subjects with and without endothelial dys-function in this cohorts of cardiovascular risk factors. Results: Out of 100 subjects with cardiovascular risk factors, mean age 46.75 (9.95) years and mean number of risk factors 2.81 (1.17), similarly, there was no significant difference in the rates of metabolic syndrome among subjects with and without endothelial dysfunction (84.85% vs 79.10% respectively; p=0.67). Only age and hypertension were associated with endothelial dysfunction. Conclusion: The association between metabolic syndrome and endothelial dys-function was not significantly different than the association between multiplex of risk factors and endothelial dysfunction. Therefore its putative role as a separate cardiovascular risk factors, rather than just a multiplex still remains under scrutiny if not a myth. Further well-designed study should be conducted to establish the role of metabolic syndrome as a separate cardiovascular risk factor other than just a multiplex.
Data Fusion Enables Better Recognition of Ceiling and Visibility Hazards in Aviation (2014)

Abstract Low cloud ceilings and poor visibility claim the lives of more general aviation (GA) pilots and passengers than any other cause of weather-related GA accidents. Experience shows that instrument-rated pilots as well as those rated only for visual flight are vulnerable to low ceiling and visibility (C&amp;V), making total avoidance the most powerful strategy available to a GA pilot dealing with these hazards. The weather awareness needed for avoidance begins with the recognition of current conditions. This article outlines how fusion of surface, satellite, and terrain data yields a graphical analysis product that enables GA pilots, dispatchers, and weather briefers to better visualize the areal distribution of recent and current C&amp;V conditions across the contiguous U.S. The product is available at www.aviationweather.gov/adds/cv and indicates ceilings less than 1,000 ft above ground level, visibilities less than 3 statute miles, and regions where terrain obscuration is possible. The product is also viewable in the context of interactive geographic information system data via the experimental Helicopter Emergency Medical Services Tool available at http://weather.aero/tools/desktopapps/hemstool. The authors summarize verification results and outline work toward a next-generation product that incorporates the use of model forecast data and weather camera imagery to improve information in data-sparse regions. This next-generation product is in development for initial use in Alaska.
ChemInform Abstract: KSbOSiO4: A New Isomorphous Derivative of KTiOPO4 (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice (2011)

Cannabinoid receptors (CBRs) play an important role in a variety of physiological functions and have been considered drug targets for obesity and psychiatric disorders. In particular, the CB1R is highly expressed in brain regions crucial to learning and memory processes, and several lines of evidence indicate that pharmacological blockade of this receptor could have therapeutic applications in the treatment of cognitive disorders. In this study, we investigated whether MK-7128 (0.1, 0.3, and 1 mg/kg, orally), a novel and selective CB1R inverse agonist, could improve learning and memory deficits induced by scopolamine (1 mg/kg, subcutaneously) in mice. The investigators also assessed CB1R occupancy in the brain to ensure target engagement of MK-7128, and showed that MK-7128 significantly improved both Y-maze spontaneous alternation and object habituation performance in scopolamine-treated mice and inhibits the binding of radioiodinated AM251 in murine cortex and hippocampus. These data indicate that MK-7128 improves cognitive performance in a model of cholinergic hypofunction and suggest that efficacy is achieved at relatively low levels of CB1R occupancy in the brain. Our results extend earlier findings suggesting a role of CB1Rs in the modulation of memory processes and a potential therapeutic application for CB1R inverse agonists in cognitive disorders.
Domain Decomposition and Space Filling Curves in Toolpath Planning and Generation (1998)

Ever increasing computer performance, along with significant developments in CADI CAM technology and high precision digital motion controllers lead to rapid and significant developments in the field ofrapid prototypingjfabrication. Together, these elements offer a wide range of possible approaches in the toolpath planning issue; two main sets have been analyzed and applied to Fused Deposition Modeling process. Domain decomposition is a frequently used technique in computational methods. Within the context of present study, this approach is used to divide arbitrary layer geometries into smaller regions of simpler shape. A foreseeable advantage in such an approach is maximizing strength characteristics through thermal management. This is achieved by utilizing space filling curves which are mathematical entities that offer the possibility of building a wide range of structures, covering the surface of a single layer with one continuous curve. To evaluate the proposed concepts, ABS structures and ceramic green bodies have been successfully built.
Location based experience design for mobile augmented reality (2014)

The main strength of Augmented Reality (AR) technology is the ability to immediately provide context in unfamiliar environments and experiences, representing digital virtual information that is associated with real world objects. AR has a proven record of commercial applications from tourism and entertainment industries to manufacturing and support services. In this work we are presenting a set of design decisions based on empirical observations for outdoor Augmented Reality. Present work led us to develop a consumer AR browser for mobile and wearable devices to be used in natural, uncontrolled settings.
THE USE OF HIBERNATION INDUCTION TRIGGERS FOR CARDIAC TRANSPLANT PRESERVATION1,2 (1997)

Cardiac transplant is hindered by donor shortage and preservation time. Extended extracorporeal preservation could increase the number and distribution of hearts for transplantation. Interestingly, mammalian hibernation biology closely parallels the altered cardiac cellular physiology noted with hypothermic organ storage. The present study undertook to test whether treatment with hibernation induction triggers could improve myocardial functional recovery following prolonged ischemic storage in a nonhibernating mammalian model. To study this hypothesis, isolated rabbit hearts had baseline functional and metabolic parameters recorded and then received either hypothermic storage only or standard cardioplegia, or cardioplegia containing 1 mg/kg D-Ala2-Leu5-enkaphalin (DADLE), which mimics natural hibernation, or preperfusion with DADLE, administered for 15 min at 2 mmol, 25 min prior to cardioplegic ischemia. Hearts were then subjected to 18 hr of global ischemic storage at 4 degrees C. Isovolumic developed pressure, coronary flows, and myocardial oxygen consumption were significantly improved with DADLE pretreatment vs. all groups after storage and reflow. Furthermore, DADLE hearts demonstrated better histological ultrastructure preservation following prolonged storage ischemia. This study demonstrates that hibernation protection with DADLE is beneficial for prolonged cardiac storage. The use of hibernation induction triggers is promising for organ preservation and deserve further mechanistic study.
Effects of Metal Coating on Self-Assembled Monolayers on Gold. 1. Copper on Dodecanethiol and Octadecanethiol (2002)

We report studies on the perturbations induced by the evaporation of copper metal overlayers on dodecanethiol and octadecanethiol self-assembled monolayers (SAMs). Monolayers were characterized after deposition on a gold substrate from an ethanolic solution, after heat treatment alone, after acid treatment alone, after physical evaporation of a submonolayer copper layer alone, and after deposition of an optically thick copper layer followed by stripping with a nitric acid solution. The monolayers were studied using cyclic voltammetry, grazing-angle IR spectroscopy and X-ray photoelectron spectroscopy. Cyclic voltammetry revealed that the gold electrodes are passivated by the formation of the monolayers. The degree of passivation does not decrease with exposure to <6 N nitric acid solutions or after copper deposition and removal with nitric acid. The IR studies indicate that the deposition of metal induced a reorganization, interpreted as increased disordering, of the monolayer, that is similar to heat treatment alone. X-ray photoelectron spectroscopy experiments showed no evidence of bond formation between carbon and copper upon deposition of the copper layer on the SAM.