gebhart/patrepeval huggingface dataset:
Evaluation of Viscoelastic Behavior for Liquid Film Surface Appearance in Multilayer Flow Used by Numerical Analysis (2009)

In this study, we examined to clarify main factor that affect to the liquid film surface appearance for multilayer flow that consisted of polymer solution of different rheological behavior. The correlation of the viscoelastic flow behavior in the three-layer channel and the liquid film surface appearance was examined by numerical analysis. As the results, the following technical findings were obtained. (1) The first normal stress difference generated in the sub-fluid, which was a main factor for the generation of the surface irregularity was large at the vena contracta and the merging part. However, the main factor for the generation of the surface irregularity was the first normal stress difference generated in the sub-fluid at the vena contracta. Because the first normal stress difference generated in the sub-fluid at the merging part was perfectly relaxed in the channel. (2) The factor analysis between layers was conducted to specify the main factor for the generation of the surface irregularity. As the result, it was understood that there is a strong correlation between the frequency of the surface irregularity and the force to act on the sub-fluid around the interface at the vena contracta (Fs). Moreover, it was understood that there is a correlation between Fs and the interfacial roughness (Ra-int) of the distance at the vena contracta to the discharge part. (3) Sharping the inflow angle and chamfering the inflow corner are effective to the reduction of the force both to act on the sub-fluid around the interface and to control the generation of the surface irregularity.
Synthesis of Pyridine-Containing Macrocycles by Cobalt-Mediated Trimerization of Triply-Bonded Species [J. Am. Chem. Soc. 2001, 123, 3157−3158]. (2002)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionSynthesis of Pyridine-Containing Macrocycles by Cobalt-Mediated Trimerization of Triply-Bonded Species [J. Am. Chem. Soc.2001, 123, 3157−3158].Alessandro F. Moretto, Han-Cheng Zhang, and Bruce E. MaryanoffCite this: J. Am. Chem. Soc. 2002, 124, 23, 6792Publication Date (Web):May 15, 2002Publication History Published online15 May 2002Published inissue 1 June 2002https://pubs.acs.org/doi/10.1021/ja025102zhttps://doi.org/10.1021/ja025102zcorrectionACS PublicationsCopyright © 2002 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views495Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (15 KB) Get e-Alertsclose Get e-Alerts
Priority-aware transfer of SVC encoded video over MIMO communications system (2009)

A cross-layer method is proposed for optimizing, controlling and improving the quality of video transmission over wireless networks using scalable video coding (SVC) and multiple-input multiple-output (MIMO) transmission with channel state feedback (CSI). Multiple video sub-streams are created by a content-based partitioning and sorting of the enhancement layers produced with the SVC extension of H.264/AVC. Unlike in existing methods, the prioritized bit-streams are transmitted by actively performing power adjustment and antenna selection using a bit-stream prioritization matrix to modify the power allocation procedure of a recently proposed MIMO scheme. The power allocation strategy results in different bit error rate (BER) experienced by the bit-streams. Simulation results show an improved performance compared with power allocation that equalizes BER over the different channels.
100 GHz colliding pulse mode locked quantum dot lasers directly grown on Si for WDM application (2019)

We demonstrate the first 100 GHz 5th harmonic colliding pulse mode locked quantum dot laser directly grown on CMOS compatible on axis (001) silicon substrate with ~ 0.9 Tb/s PAM-4 transmission capacity.
View-Specific Assessment of L2 Spoken English (2022)

The growing demand for learning English as a second language has increased interest in automatic approaches for assessing and improving spoken language proficiency. A significant challenge in this field is to provide interpretable scores and informative feedback to learners through individual viewpoints of learners’ proficiency, as opposed to holistic scores. Thus far, holistic scoring remains commonly applied in large-scale commercial tests. As a result, an issue with more detailed evaluation is that human graders are generally trained to provide holistic scores. This paper investigates whether view-specific systems can be trained when only holistic scores are available. To enable this process, view-specific networks are defined where both their inputs and structure are adapted to focus on specific facets of proficiency. It is shown that it is possible to train such systems on holistic scores, such that they provide view-specific scores at evaluation time. View-specific networks are designed in this way for pronunciation, rhythm, text, use of parts of speech and grammatical accuracy. The relationships between the predictions of each system are investigated on the spoken part of the Linguaskill proficiency test. It is shown that the view-specific predictions are complementary in nature and capture different information about proficiency.
The Movement of Glucose and Glycine Through the Tissues of Corymorpha Palma Torrey (Coelenterata, Hydrozoa) (1972)

ABSTRACT The rate of diffusion of 14C-labelled glucose and glycine across isolated mesogloea and across the mesogloea and cell layers of the large solitary hydroid, Corymorpha was measured. Diffusion coefficients of glucose and glycine in mesogloea were found to be about 16 times lower than their values in water and of the same order as their values in dialysis tubing and Millipore filters,
Visual impairment and vision‐related quality of life in the Early Manifest Glaucoma Trial after 20 years of follow‐up (2015)

Our results support the widespread, albeit arbitrary, use of a better-eye visual field of <50% as an important threshold for a significant reduction in VRQOL.
Regioselective synthesis of 9‐substituted‐8‐azaguanines (5‐amino‐3‐substituted‐3,6‐dihydro‐7H‐1,2,3‐triazolo[4,5‐d]pyrimidin‐7‐one) (1996)

Abstract By modifying previously described methods for the synthesis of 9‐substituted‐guanines from imidazoles, we have developed a new procedure for the regioselective synthesis of 9‐substituted‐8‐azaguanines (5‐amino‐3‐substituted‐3,6‐dihydro‐7 H ‐1,2,3‐triazolo[4,5‐ d ]pyrimidin‐7‐one) from triazoles in high yields. The method seems suitable for the introduction of a variety of substituents including sugars, carbocyclic, acyclic and carboacyclic chains.
Racial Disparities in the Utilization and Outcomes of Temporary Mechanical Circulatory Support for Acute Myocardial Infarction-Cardiogenic Shock (2021)

Racial disparities in utilization and outcomes of mechanical circulatory support (MCS) in patients with acute myocardial infarction-cardiogenic shock (AMI-CS) are infrequently studied. This study sought to evaluate racial disparities in the outcomes of MCS in AMI-CS. The National Inpatient Sample (2012-2017) was used to identify adult AMI-CS admissions receiving MCS support. MCS devices were classified as intra-aortic balloon pump (IABP), percutaneous left ventricular assist device (pLVAD) or extracorporeal membrane oxygenation (ECMO). Self-reported race was classified as white, black and others. Outcomes included in-hospital mortality, hospital length of stay and discharge disposition. During this period, 90,071 admissions were included with white, black and other races constituting 73.6%, 8.3% and 18.1%, respectively. Compared to white and other races, black race admissions were on average younger, female, with greater comorbidities, and non-cardiac organ failure (all <i>p</i> < 0.001). Compared to the white race (31.3%), in-hospital mortality was comparable in black (31.4%; adjusted odds ratio (aOR) 0.98 (95% confidence interval (CI) 0.93-1.05); <i>p</i> = 0.60) and other (30.2%; aOR 0.96 (95% CI 0.92-1.01); <i>p</i> = 0.10). Higher in-hospital mortality was noted in non-white races with concomitant cardiac arrest, and those receiving ECMO support. Black admissions had longer lengths of hospital stay (12.1 ± 14.2, 10.3 ± 11.2, 10.9 ± 1.2 days) and transferred less often (12.6%, 14.2%, 13.9%) compared to white and other races (both <i>p</i> < 0.001). In conclusion, this study of AMI-CS admissions receiving MCS devices did not identify racial disparities in in-hospital mortality. Black admissions had longer hospital stay and were transferred less often. Further evaluation with granular data including angiographic and hemodynamic parameters is essential to rule out racial differences.
ADAM9 Is Involved in Pathological Retinal Neovascularization (2009)

Pathological ocular neovascularization, caused by diabetic retinopathy, age-related macular degeneration, or retinopathy of prematurity, is a leading cause of blindness, yet much remains to be learned about its underlying causes. Here we used oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularization (CNV) to assess the contribution of the metalloprotease-disintegrin ADAM9 to ocular neovascularization in mice. Pathological neovascularization in both the OIR and CNV models was significantly reduced in Adam9(-/-) mice compared to wild-type controls. In addition, the level of ADAM9 expression was strongly increased in endothelial cells in pathological vascular tufts in the OIR model. Moreover, tumor growth from heterotopically injected B16F0 melanoma cells was reduced in Adam9(-/-) mice compared to controls. In cell-based assays, the overexpression of ADAM9 enhanced the ectodomain shedding of EphB4, Tie-2, Flk-1, CD40, VCAM, and VE-cadherin, so the enhanced expression of ADAM9 could potentially affect pathological neovascularization by increasing the shedding of these and other membrane proteins from endothelial cells. Finally, we provide the first evidence for the upregulation of ADAM9-dependent shedding by reactive oxygen species, which in turn are known to play a critical role in OIR. Collectively, these results suggest that ADAM9 could be an attractive target for the prevention of proliferative retinopathies, CNV, and cancer.
Data from Cancers as Wounds that Do Not Heal: Differences and Similarities between Renal Regeneration/Repair and Renal Cell Carcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;Cancers have been described as wounds that do not heal, suggesting that the two share common features. By comparing microarray data from a model of renal regeneration and repair (RRR) with reported gene expression in renal cell carcinoma (RCC), we asked whether those two processes do, in fact, share molecular features and regulatory mechanisms. The majority (77%) of the genes expressed in RRR and RCC were concordantly regulated, whereas only 23% were discordant (i.e., changed in opposite directions). The orchestrated processes of regeneration, involving cell proliferation and immune response, were reflected in the concordant genes. The discordant gene signature revealed processes (e.g., morphogenesis and glycolysis) and pathways (e.g., hypoxia-inducible factor and insulin-like growth factor-I) that reflect the intrinsic pathologic nature of RCC. This is the first study that compares gene expression patterns in RCC and RRR. It does so, in particular, with relation to the hypothesis that RCC resembles the wound healing processes seen in RRR. However, careful attention to the genes that are regulated in the discordant direction provides new insights into the critical differences between renal carcinogenesis and wound healing. The observations reported here provide a conceptual framework for further efforts to understand the biology and to develop more effective diagnostic biomarkers and therapeutic strategies for renal tumors and renal ischemia. (Cancer Res 2006; 66(14): 7216-24)&lt;/p&gt;&lt;/div&gt;
Novel In Vivo Model for the Study of Human Immunodeficiency Virus Type 1 Transcription Inhibitors: Evaluation of New 6-Desfluoroquinolone Derivatives (2007)

Two novel 6-desfluoroquinolone derivatives, HM-12 and HM-13, were evaluated for anti-human immunodeficiency virus (anti-HIV) activity in acutely, chronically, and latently HIV type 1 (HIV-1)-infected cell cultures and were found to behave as potent HIV-1 transcription inhibitors. In order to extend this result in vivo, we developed an artificial hu-SCID mouse model for HIV-1 latency based on SCID mice engrafted with latently HIV-1-infected promyelocytic OM-10.1 cells in which HIV-1 can be reactivated in vivo by the administration of human tumor necrosis factor alpha (hTNF-alpha). Treating these SCID mice with HM-12 or HM-13 prior to hTNF-alpha stimulation resulted in a pronounced suppressive effect on viral reactivation. Since both quinolone derivatives were able to inhibit the reactivation of HIV-1 from this artificial viral reservoir in vivo, we provide encouraging evidence for the use of quinolones in the control of HIV-1 infections.
Color and shape changing polymeric ribbons and sheets (2023)

The present invention herein provides the design, synthesis and characterization of compositions comprising asymmetric bolaamphiphilic lipids that form extended polymeric ribbons and wide sheets. These compositions may be doped, or interspersed, with various compounds to fine-tune the fluidity and rigidity of the bolaamphiphilic lipid composition, and promote other morphologies of the composition, including fluid vesicles and truncated flat sheets. Upon an increase in pH these compositions undergo a calorimetric and morphological transformation.
Multivariate Scale mixtures for joint sparse regularization in multi-task learning (2017)

In this paper we address the problem of learning shared sparse representation across several tasks. Assuming that the tasks share a common set of relevant features across all tasks is highly restrictive. This acts as a motivation to look for a generalized model which will be able to learn any correlation structure present between the tasks. We propose a generalized scale mixture distribution, the Multivariate Power Exponential Scale Mixture (M-PESM), as a joint sparsity promoting prior and derive a unified framework which consists of many of the popular Multitask Learning algorithms. Our proposed unified model also has the ability to learn any present correlation structure between tasks which leads to a more robust framework.
Supplementary document for Multi-focus off-axis zone plates for X-ray free-electron laser experiments - 4693976.pdf (2020)

mathematical derivations
PI3K-dependent Reprogramming of Hexokinase Isoforms Regulates B Lymphocyte Metabolism (2020)

Abstract The PI3K signalling pathway is known to regulate B cell metabolic programming upon activation, but the mechanisms involved are not well understood. Here we find that the PI3K pathway controls reprogramming of hexokinases (HKs), the enzymes that convert glucose into glucose-6-phosphate as a key rate-limiting step of glycolysis and other metabolic pathways. In primary mouse B cells, PI3K pathway inhibition substantially impaired the activation-induced increase in extracellular acidification rates (ECAR), a measure of glycolysis. In contrast, B cells isolated from PI3Kdelta gain-of-function mutant mice exhibit elevated ECAR. We find that B cell activation substantially elevates protein levels of HK2 and HK3 isoforms, but not HK1, in a PI3K-dependant manner. PI3K or mTOR inhibition significantly reduced induction of HK2 and HK3 expression, whereas Akt inhibition did not affect HK isoform expression. In human B lymphoma cells, HK isoforms differ significantly in their degree of mitochondrial localization, with HK1 being mitochondrial, HK3 being cytoplasmic and HK2 present in both mitochondria and cytoplasm. To assess whether HK isoforms have unique non-redundant functions, HK2-deficient B lymphoma cells were generated and were found to exhibit decreased ECAR as well as significant changes in metabolomic profile, despite normal expression and localization of HK1 and HK3. Taken together, our study reveals that PI3K-dependant reprogramming of hexokinase isoforms can impact on B cell glycolysis and other metabolic pathways. Studies in progress are examining the functional importance of HK2 in antibody responses using mice with B cell-specific deletion of this enzyme.
Perception of the Arabidopsis Danger Signal Peptide 1 Involves the Pattern Recognition Receptor AtPEPR1 and Its Close Homologue AtPEPR2 (2010)

Plasma membrane-borne pattern recognition receptors, which recognize microbe-associated molecular patterns and endogenous damage-associated molecular patterns, provide the first line of defense in innate immunity. In plants, leucine-rich repeat receptor kinases fulfill this role, as exemplified by FLS2 and EFR, the receptors for the microbe-associated molecular patterns flagellin and elongation factor Tu. Here we examined the perception of the damage-associated molecular pattern peptide 1 (AtPep1), an endogenous peptide of Arabidopsis identified earlier and shown to be perceived by the leucine-rich repeat protein kinase PEPR1. Using seedling growth inhibition, elicitation of an oxidative burst and induction of ethylene biosynthesis, we show that wild type plants and the pepr1 and pepr2 mutants, affected in PEPR1 and in its homologue PEPR2, are sensitive to AtPep1, but that the double mutant pepr1/pepr2 is completely insensitive. As a central body of our study, we provide electrophysiological evidence that at the level of the plasma membrane, AtPep1 triggers a receptor-dependent transient depolarization through activation of plasma membrane anion channels, and that this effect is absent in the double mutant pepr1/pepr2. The double mutant also fails to respond to AtPep2 and AtPep3, two distant homologues of AtPep1 on the basis of homology screening, implying that the PEPR1 and PEPR2 are responsible for their perception too. Our findings provide a basic framework to study the biological role of AtPep1-related danger signals and their cognate receptors.
A novel surface marker (B203.13) of human haemopoietic progenitors, preferentially expressed along the B and myeloid lineages (1998)

We used a monoclonal antibody (mAb) (B203.13, IgM) generated from a mouse immunized with the human B/myeloid bi-phenotypic B1b cell line, to analyse haemopoietic cells. The antigen recognized by this mAb is expressed on most adult and umbilical cord blood CD21+ B cells, at minimal density on mature monocytes, and is undetectable on granulocytes, T, natural killer (NK) cells, and erythrocytes. Within umbilical cord blood and adult bone marrow haemopoietic progenitor cells, the B203.13 mAb recognized a surface marker, present on progenitor cells of several haemopoietic lineages, that was transiently expressed on early erythroid and T/NK progenitors, and was preferentially maintained on cells of the B and myeloid lineages. Within the CD34+ cells, B203.13 was expressed on early committed myeloid (CD33+) and erythroid (CD71dim) progenitor cells, as confirmed in colony formation assays. The mAb also reacted with cells of B and myeloid chronic leukaemias and cell lines. These data define B203.13 mAb as a novel reagent useful for the characterization of haemopoietic progenitors and leukaemias.
Considerations in hiPSC-derived cartilage for articular cartilage repair (2018)

Cartilage generated from allogeneic hiPSC-derived cartilage can be used to repair articular cartilage damage.
Susceptibility of Mycobacterium abscessus to Antimycobacterial Drugs in Preclinical Models (2015)

Over the last 10 years, Mycobacterium abscessus group strains have emerged as important human pathogens, which are associated with significantly higher fatality rates than any other rapidly growing mycobacteria. These opportunistic pathogens are widespread in the environment and can cause a wide range of clinical diseases, including skin, soft tissue, central nervous system, and disseminated infections; by far, the most difficult to treat is the pulmonary form. Infections with M. abscessus are often multidrug-resistant (MDR) and require prolonged treatment with various regimens and, many times, result in high mortality despite maximal therapy. We report here the evaluation of diverse mouse infection models for their ability to produce a progressive high level of infection with M. abscessus. The nude (nu/nu), SCID (severe combined immunodeficiency), gamma interferon knockout (GKO), and granulocyte-macrophage colony-stimulating factor (GMCSF) knockout mice fulfilled the criteria for an optimal model for compound screening. Thus, we set out to assess the antimycobacterial activity of clarithromycin, clofazimine, bedaquiline, and clofazimine-bedaquiline combinations against M. abscessus-infected GKO and SCID murine infection models. Treatment of GKO and SCID mice with a combination of clofazimine and bedaquiline was the most effective in decreasing the M. abscessus organ burden.
Anti-COX-2 Autoantibody is a Novel Marker of Immune Aplastic Anemia (2022)

Abstract In immune aplastic anemia (IAA), severe pancytopenia results from the immune-mediated destruction of hematopoietic stem cells. Several autoantibodies have been reported, but no clinically applicable autoantibody tests are available for IAA. We screened autoantibodies using a microarray containing &gt; 9 000 proteins and validated the findings in a large international cohort of IAA patients (n = 405) and controls (n = 815). We identified a novel autoantibody that binds to the C-terminal end of cyclo-oxygenase 2 (COX-2, aCOX-2 Ab). 37% of all adult IAA patients tested positive for aCOX-2 Ab, while only 1.7% of the controls were aCOX-2 Ab positive. Sporadic non-IAA aCOX-2 Ab positive cases were observed among patients with related bone marrow failure diseases, multiple sclerosis, and type I diabetes, whereas no aCOX-2 Ab seropositivity was detected in the healthy controls, in patients with non-autoinflammatory diseases or rheumatoid arthritis. In IAA, anti-COX-2 Ab positivity correlated with age and the HLA-DRB1*15:01 genotype. 83% of the &gt; 40 years old IAA patients with HLA-DRB1*15:01 were anti-COX-2 Ab positive, indicating an excellent sensitivity in this group. aCOX-2 Ab positive IAA patients also presented lower platelet counts. Our results suggest that aCOX-2 Ab defines a distinct subgroup of IAA and may serve as a valuable diagnostic tool.
Nanocolumn Light Emitters from Ultraviolet to Red and InGaN/GaN Nanocolumn Arrays (2009)

InGaN-based nanocolumn LEDs from ultraviolet to red were fabricated through self-assembly of GaN nanocolumns by rf-MBE. Ti-mask selective area growth (SAG) was employed to fabricate uniform arrays of InGaN/GaN nanocolumns, and the photoluminescence observation of the arrays demonstrated that the emission color changed from blue to red with increased nanocolumn diameter.
ChemInform Abstract: Enantioselective Conjugate Silyl Additions to α,β‐Unsaturated Aldehydes Catalyzed by Combination of Transition Metal and Chiral Amine Catalysts. (2011)

Abstract A combined CuCl—nitrobenzoic acid—prolinol‐derived chiral Tms ether catalyst is successfully applied in the asymmetric hydrosilylation of α,β‐unsaturated aldehydes.