gebhart/patrepeval huggingface dataset:
Phytochemicals, antioxidant and antimicrobial activity of Hibiscus sabdariffa, Centella asiatica, Moringa oleifera and Murraya koenigii leaves (2011)

Many exotic vegetables remain uninvestigated as potential sources of bioactive nutrients. The objective was to determine and compare nutrients, selected phytochemicals and antioxidant and antimicrobial activities in three types of leafy vegetables and a spice, including Hibiscus sabdariffa, Centella asiatica, Moringa oleifera, and Murraya koenigii. Proximate analysis, vitamin C, beta-carotene, phenolics and flavanoids contents including antioxidant capacity and antimicrobial activity were determined. Soluble dietary fiber, vitamin C and lutein contents were highest in the leaf of H. sabdariffa including high contents of flavanoids and phenolic acids. M. oleifera leaf had the highest contents of carotenoids, (-) epicatechin and o-coumaric acid while M. koenigii’s leaf had the highest content of benzoic acid. The anti-radical power values were 1.03, 0.63, 0.41, and 1.19 mg DPPH/mg extract for the ethanolic extracts from C. asiatica, M. koenigii, H. sabdariffa, and M. oleifera leaves, respectively. Total phenolic contents of the ethanolic extracts significantly affected their anti-radical power with a strong positive correlation between the total phenolic contents and their anti-radical power values. Antimicrobial activity of the three leaf extracts against Listeria monocytogenes,Salmonella typhimurium, and E. coli O157:H7 resulted in H. sabdariffa L. to exhibit the most antibacterial activity among all extracts evaluated in this study showing pathogen reduction to non-detectable limits. These leaves can be used as potential sources of vitamins, minerals, phenolics with antioxidant activity and as antimicrobial agents with potential medicinal value.

	 

	Key words: Phytochemicals, Moringa oleifera, Hibiscus sabdariffa, Murraya koenigii,antioxidant, antimicrobial.
A Rapid Method for Isolation of Retinal Pigment Epithelial Cells from Rat Eyeballs (1995)

A new, simple method for isolating retinal pigment epithelial (RPE) cells from rat eyeballs was developed: incubation of the eyeballs in 0.1% proteinase K solution. This method yielded an average of 4 x 10(4) viable RPE cells from each Sprague-Dawley rat eyeball in 1 h. These RPE cells were hexagonal and had cytokeratin in their cytoplasm and numerous microvilli on their surface, similar to RPE cells evaluated in vivo. The results of this study thus show that our method for incubating eyeballs in proteinase K can provide good-quality RPE cells in sufficient quantities for study in a short time.
Imaging the intracellular degradation of biodegradable polymer nanoparticles (2014)

In recent years, the development of smart drug delivery systems based on biodegradable polymeric nanoparticles has become of great interest. Drug-loaded nanoparticles can be introduced into the cell interior via endocytotic processes followed by the slow release of the drug due to degradation of the nanoparticle. In this work, poly(L-lactic acid) (PLLA) was chosen as the biodegradable polymer. Although common degradation of PLLA has been studied in various biological environments, intracellular degradation processes have been examined only to a very limited extent. PLLA nanoparticles with an average diameter of approximately 120 nm were decorated with magnetite nanocrystals and introduced into mesenchymal stem cells (MSCs). The release of the magnetite particles from the surface of the PLLA nanoparticles during the intracellular residence was monitored by transmission electron microscopy (TEM) over a period of 14 days. It was demonstrated by the release of the magnetite nanocrystals from the PLLA surface that the PLLA nanoparticles do in fact undergo degradation within the cell. Furthermore, even after 14 days of residence, the PLLA nanoparticles were found in the MSCs. Additionally, the ultrastructural TEM examinations yield insight into the long term intercellular fate of these nanoparticles. From the statistical analysis of ultrastructural details (e.g., number of detached magnetite crystals, and the number of nanoparticles in one endosome), we demonstrate the importance of TEM studies for such applications in addition to fluorescence studies (flow cytometry and confocal laser scanning microscopy).
Heat shock factor is required for growth at normal temperatures in the fission yeast Schizosaccharomyces pombe. (1993)

Schizosaccharomyces pombe is becoming an increasingly useful organism for the study of cellular processes, since in certain respects, such as the cell cycle and splicing, it is similar to metazoans. Previous biochemical studies have shown that the DNA binding ability of S. pombe heat shock factor (HSF) is fully induced only under stressed conditions, in a manner similar to that of Drosophila melanogaster and humans but differing from the constitutive binding by HSF in the budding yeasts. We report the isolation of the cDNA and gene for the HSF from S. pombe. S. pombe HSF has a domain structure that is more closely related to the structure of human and D. melanogaster HSFs than to the structure of the budding yeast HSFs, further arguing that regulation of HSF in S. pombe is likely to reflect regulation in metazoans. Surprisingly, the S. pombe HSF gene is required for growth at normal temperatures. We show that the S. pombe HSF gene can be replaced by the D. melanogaster HSF gene and that strains containing either of these genes behave similarly to transiently heat-shocked strains with respect to viability and the level of heat-induced transcripts from heat shock promoters. Strains containing the D. melanogaster HSF gene, however, have lower growth rates and show altered morphology at normal growth temperatures. These data demonstrate the functional conservation of domains of HSF that are required for response to heat shock. They further suggest a general role for HSF in growth of eukaryotic cells under normal (nonstressed) growth conditions.
Case–control study of neurocognitive function in euthymic patients with bipolar disorder: An association with mania (2002)

Impaired verbal learning and memory may be a trait variable in bipolar disease. There are implications for adherence to medication and relapse and for the role of early treatment interventions. Prospective designs and targeting first-episode groups may help to differentiate trait v. disease process effects.
CDC6 mRNA Expression Is Associated with the Aggressiveness of Prostate Cancer (2018)

<i>CDC6</i> expression is associated with aggressive clinicopathological characteristics in PCa. CDC6 may be a potential diagnostic and prognostic marker in PCa patients.
Cyclic Prefix-Based Universal Filtered Multicarrier System and Performance Analysis (2016)

Recently proposed universal filtered multicarrier (UFMC) system is not an orthogonal system in multipath channel environments and might cause significant performance loss. In this paper, the authors propose a cyclic prefix (CP) based UFMC system and first analyze the conditions for interference-free one-tap equalization in the absence of transceiver imperfections. Then the corresponding signal model and output signal-to-noise ratio expression are derived. In the presence of carrier frequency offset, timing offset, and insufficient CP length, the authors establish an analytical system model as a summation of desired signal, intersymbol interference, intercarrier interference, and noise. New channel equalization algorithms are proposed based on the derived analytical signal model. Numerical results show that the derived model matches the simulation results precisely, and the proposed equalization algorithms improve the UFMC system performance in terms of bit error rate.
Preface to the Second Edition (2010)

This textbook for advanced undergraduates and graduate students emphasizes algorithms for a range of strategies for locomotion, sensing, and reasoning. It concentrates on wheeled and legged mobile robots but discusses a variety of other propulsion systems. This edition includes advances in robotics and intelligent machines over the ten years prior to publication, including significant coverage of SLAM (simultaneous localization and mapping) and multi-robot systems. It includes additional mathematical background and an extensive list of sample problems. Various mathematical techniques that were assumed in the first edition are now briefly introduced in appendices at the end of the text to make the book more self-contained. Researchers as well as students in the field of mobile robotics will appreciate this comprehensive treatment of state-of-the-art methods and key technologies.
Hyperglycemia Does Not Affect Iron Mediated Toxicity of Cultured Endothelial and Renal Tubular Epithelial Cells: Influence of L-Carnosine (2015)

Iron has been suggested to affect the clinical course of type 2 diabetes (T2DM) as accompanying increased intracellular iron accumulation may provide an alternative source for reactive oxygen species (ROS). Although carnosine has proven its therapeutic efficacy in rodent models of T2DM, little is known about its efficacy to protect cells from iron toxicity. We sought to assess if high glucose (HG) exposure makes cultured human umbilical vein endothelial cells (HUVECs) and renal proximal tubular epithelial cells (PTECs) more susceptible to metal induced toxicity and if this is ameliorated by L-carnosine. HUVECs and PTECs, cultured under normal glucose (5 mM, NG) or HG (30 mM), were challenged for 24 h with FeCl3. Cell viability was not impaired under HG conditions nor did HG increase susceptibility to FeCl3. HG did not change the expression of divalent metal transporter 1 (DMT1), ferroportin (IREG), and transferrin receptor protein 1 (TFRC). Irrespective of glucose concentrations L-carnosine prevented toxicity in a dose-dependent manner, only if it was present during the FeCl3 challenge. Hence our study indicates that iron induced cytotoxicity is not enhanced under HG conditions. L-Carnosine displayed a strong protective effect, most likely by chelation of iron mediated toxicity.
Demonstration of Dielectric Optical Magnetic Mirrors Using Phase-locked Infrared Time-domain Spectroscopy (2013)

We directly demonstrate a dielectric optical magnetic mirror using phase-locked mid-infrared time-domain spectroscopy. This magnetic mirror is formed by micron-sized cubes of tellurium fabricated on a dielectric substrate.
High-speed broadband frequency sweep of CW THz radiation (2013)

We present experimental implementation of high-speed broadband frequency sweep of CW THz radiation applicable to high-speed THz spectroscopy and tomography. A wavelength-swept laser and a distributed-feedback laser diode constitute a high-speed frequency-swept optical beat source used for photomixing.
Visualization in Concurrent Contexts: A Model (1990)

Visualization is defined as the transformation of information into a graphical form. In recent years, visualization has increasingly been used in a variety of applications. Our work focuses on the visualization of concurrent computations. We wish to collect information about the operational behavior of concurrent computations. We wish to collect information into a graphical representation, and display the resulting image.
Alberto Gitti, Alessandro Magno all'Oasi di Siwah. Il problema delle fonti (1952)

Mertens Paul. Alberto Gitti, Alessandro Magno all'Oasi di Siwah. Il problema delle fonti. In: L'antiquité classique, Tome 21, fasc. 2, 1952. pp. 515-518.
ChemInform Abstract: An Expedient and Stereoselective Route to the Perhydrophenanthrene Skeleton via Sequential Diels‐Alder Reactions. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ruboxistaurin: Review of Safety and Efficacy in the Treatment of Diabetic Retinopathy (2010)

Ruboxistaurin (Eli Lilly, Indianapolis, IN), an orally active inhibitor of the β isoform of protein kinase C (PKC), has been studied as a systemic treatment for diabetic retinopathy. PKC-β appears to be overactivated in response to hyperglycemia. This overactivation associates with various pathological effects within the retinal vascular system, including ischemia, vascular leakage, and angiogenesis. Several randomized clinical trials of ruboxistaurin have been performed. In most trials, the primary outcomes were not achieved. Analysis of secondary outcomes data from these trials has demonstrated some evidence of safety and efficacy in the treatment of diabetic retinopathy. At this time, ruboxistaurin has not received approval from the US Food and Drug Administration.
A High-throughput Pharmacoviral Approach Identifies Novel Oncolytic Virus Sensitizers (2010)

Oncolytic viruses (OVs) are promising anticancer agents but like other cancer monotherapies, the genetic heterogeneity of human malignancies can lead to treatment resistance. We used a virus/cell-based assay to screen diverse chemical libraries to identify small molecules that could act in synergy with OVs to destroy tumor cells that resist viral infection. Several molecules were identified that aid in viral oncolysis, enhancing virus replication and spread as much as 1,000-fold in tumor cells. One of these molecules we named virus-sensitizers 1 (VSe1), was found to target tumor innate immune response and could enhance OV efficacy in animal tumor models and within primary human tumor explants while remaining benign to normal tissues. We believe this is the first example of a virus/cell-based "pharmacoviral" screen aimed to identify small molecules that modulate cellular response to virus infection and enhance oncolytic virotherapy.
A New, One-Stage Pedicled Scrotal Skin Graft Urethroplasty (1986)

A new 1-stage procedure with a pedicled scrotal flap for bulbomembranous urethral reconstruction is described. The scrotal septum used as a pedicle provides good mobility to the flap. Because of this mobility the method appears to be applicable for reconstruction anywhere along the urethra.
Effects of Virtual Reality Training With Trunk Support Trainer (TruST) on Postural Kinematics (2017)

Improving functional motor deficits in patients with neurological and musculoskeletal disorders has been a primary objective of rehabilitation. Task-oriented training in physical environments is a leading approach for rehab training utilizing tasks that are challenging, adaptable, and meaningful. Although different training paradigms can be utilized in a laboratory setting, they often require expensive training equipment and personnel, limiting the number of training sessions. Creating an effective virtual reality (VR) training environment can greatly increase the repetition, cognitive engagement, and training variability. Specifically, dynamic trunk control is required for the successful completion of everyday tasks. These tasks require coordination between the head, upper and lower trunk, and the pelvis. We have developed a novel robotic device, trunk support trainer (TruST) and a VR gaming environment, which allows training in a seated posture at and beyond an individual's point of stability failure using an assist-as-needed force tunnel strategy. The VR environment consists of challenging reaching tasks where the subject's dominant hand is used to manipulate a VR drone. We conducted a study that involved three groups: ten adult subjects trained using VR, ten adult subjects trained in a physical environment (PR), and ten without TruST assistance (control group) to investigate the changes in trunk kinematics. Our study supports the hypothesis that a single training session with TruST in both VR and PR can increase lower trunk range of motion. This approach may be useful for creating training variability and translating therapy in home settings.
In-Vivo Imaging of Transgene Expression Using the Herpesviral Thymidine Kinase Reporter Gene (2007)

The herpesviral thymidine kinase reporter gene (HSV1-tk) is at present best established for assessment of transgene expression using nuclear imaging. This chapter first summarizes the current status of gene and cell therapeutic cardiac interventions and highlights open issues which may be resolved by use of noninvasive imaging. Primary targets for cardiovascular gene therapy have been myocardial ischemia and heart failure, but applications in other diseases such as arrhythmia, restenosis, and transplant rejection are also being pursued. Cell therapy offers the advantage over gene therapy that an entire, flexible system is installed which may dynamically adapt itself to the environment and replace lost function of damaged tissue. Detection of the level of reporter gene product activity through accumulation of a reporter probe provides indirect information about the level of reporter gene expression. Reporter gene imaging technology continues to advance. A variety of reporter genes other than HSV1-tk have been identified and successfully applied.
Simulation of ultra low-dose scans in quantum counting clinical CT (2011)

Contrary to conventional energy integrating detectors, electronics noise in quantum counting detectors (also frequently referred to as photon counting detectors) mainly affects the spectral resolution of the detector. There is almost no impact on the counting signal itself. This promises improved image quality due to image noise reduction in scans obtained from clinical computed tomography (CT) examinations with lowest X-ray tube currents or strongly attenuating obese patients. In most of these examinations, noise from the electronics dominates the image noise when using conventional detectors. Applying quantum counting detectors instead can improve image quality of ultra low-dose scans. This improvement may as well be used to reduce X-ray dose while maintaining image noise on the level of conventional detectors. To quantify these benefits, we have simulated sinograms of various slice scans of the human body, using the parametric 3D XCAT phantom (abdomen, shoulders) and a geometric DRASIM phantom (cranium). The simulation chain includes modeling the X-ray source, beam attenuation in the patient, and calculation of the detector response followed by data corrections and image reconstruction.We quantify the image noise in selected Region Of Interest (ROI) in the difference image of two scans that differ only in their image noise realization. Furthermore, we provide a direct comparison of image noise in energy integrating and quantum counting CT system concepts.
Loss of heterozygosity for chromosome 11 in adenocarcinoma of the stomach. (1996)

Loss of heterozygosity (LOH) at several chromosomal loci is a common feature of the malignant progression of human tumors. In the case of chromosome 11, LOH has been well documented in several types of solid neoplasms, including gastric carcinoma, suggesting the presence of suppressor gene(s) at 11p15 and 11q22-23. Little is currently known about the molecular events occurring during the development of gastric cancer. To define the regions of chromosome 11 involved in gastric cancer progression, we used high-density polymorphic markers to screen for LOH in matched normal and tumor tissue DNA from 60 primary gastric carcinomas. We found that 21% of the tumors showed LOH simultaneously at 11p15 and 11q22-23, 41% had LOH at 11p15, and 30% had LOH at 11q22-23. We confirm that the minimal critical area of LOH for 11p15.5 is the approximately 2-Mb region between loci D11S1318 and D11S988. However, when we analyzed the pattern of LOH according to the country of origin of the patient, LOH for 11q22-23 alone was found only in cases from Italy. The minimal critical region of LOH at 11q22-23 is identical to that identified for other solid tumors, suggesting that the same putative tumor suppressor gene(s) contained within this region is involved in the pathogenesis of several common human tumors.
Maximal k-Clique Scheduling: A simple algorithm to bound maximal independent graph scheduling (2011)

In this paper, we study interference networks with local views, where each node only knows the channel gains of h hops around them, leading to mismatched knowledge about the network. For networks with a local view, we propose a new sub-network scheduling called Maximal k-Clique Scheduling (MCS). A key benefit of MCS is that it can be explicitly constructed and hence easier to analyze compared to prior sub- graph schedulers. Our main result is that MCS can be used to bound the performance from above and below of a more complex sub-graph scheduling algorithm, known as Maximal Independent Graph Scheduling (MIGS), which in many cases does not have a known explicit construction.
Disparities in outcomes among patients diagnosed with cancer associated with emergency department visits (2021)

Abstract Importance Diagnosis of cancer in the emergency department (ED) may be associated with poor outcomes, related to socioeconomic (SES) disparities, however data are limited. Objective To examine the morality and associated disparities for cancer diagnoses made less than six months after an ED visit. Design This study is case-control analysis of the Indiana State Department of Health Cancer Registry, and the Indiana Network for Patient Care. First time diagnoses of ICD-“cancer” appearing in the registry between January 2013 and December 2017 were included. Cases were patients who had an ED visit in the 6 months before their cancer diagnosis; controls had no recent ED visits. Main Outcome(s) and Measure(s) Primary outcome was mortality, comparing ED-associated mortality to non-ED-associated. Secondary outcomes include SES and demographic disparities. Results 134,761 first-time cancer patients were identified, including 15,432 (11.5%) cases. In cases and controls, the mean age was same at 65 and the Charlson Comorbidity Index (CCI) was the same at 2.0 in both groups. More of the ED cohort were Black than the non-ED cohort (12.4% vs 7.4%, P&lt;.0001, Chi Square) and more were low income (36.4%. vs 29.3%). The top 3 ED-associated cancer diagnoses were lung (18.4%), breast (8.9%), and colorectal cancer (8.9%), vs. the non-ED cohort were breast (17%), lung (14.9%), and prostate cancer (10.1%). Regardless of type, all ED-associated cancers had an over three-fold higher mortality, with cumulative death rate of 32.9% for cases vs 9.0% for controls (P&lt;.0001) over the entire study period. Regression analysis predicting mortality, clustering by city, controlling for age, gender, race, SES, drug/alcohol/tobacco use, and CCI score, produced an odds ratio of 4.12 (95% CI 3.72-4.56 for ED associated cancers). Conclusion and Relevance This study found that an ED visit within 6 months prior to the first time of ICD-coded cancer is associated with Black race, low income and an overall three-fold increased risk of death. The mortality rates for ED-associated cancers are uniformly worse for all cancer types. These data suggest that additional work is needed in order to reduce disparities among ED-associated cancer diagnoses, including increased surveillance and improved transitions of care. Key Points Question Do patients diagnosed with cancer, shortly after an emergency department (ED) visit have worsened outcomes than patients with diagnoses not associated with an ED visit. Findings In this retrospective, epidemiological assessment, 134,761 patients were diagnosed with cancer, 11.5% (15,432) were seen in the ED within 6 months prior to their diagnosis. They had increased mortality, associated with racial and socioeconomic disparities. Meaning These findings imply an urgent need for improved transitions of care for minority and low-income patients with suspected cancer in the ED.
Figure S5 from RAS–MAPK Reactivation Facilitates Acquired Resistance in <i>FGFR1</i>-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR–MEK Blockade (2023)

&lt;p&gt;Figure S5 shows morphologic characterization and expression patterns of FGFR-inhibitor resistant clones&lt;/p&gt;