gebhart/patrepeval huggingface dataset:
Surface mode at isotropic–uniaxial and isotropic–biaxial interfaces (1998)

The surface mode that propagates along the interface between isotropic and uniaxial materials, as first suggested by M. I. D’Yakonov [Sov. Phys. JETP67, 714 (1988)], is quantitatively characterized in terms of (1) the range of crystallographic orientations for which the mode propagates, (2) its propagation constant β, and (3) its field profiles. Previous studies have considered only uniaxial materials whose optic axis is in the plane of the interface. We show that a surface mode can also propagate along the interface between isotropic and arbitrarily oriented uniaxial or biaxial materials. This mode is also quantitatively characterized. For the biaxial material oriented so that its optic axes lie in the plane of the interface, it is shown that this surface mode is guided over a greater range of propagation directions and that the light is confined more tightly than for any isotropic–uniaxial interface of comparable birefringence. In addition, it is shown that the surface modes that occur at isotropic–uniaxial interfaces combine to form a new type of hybrid mode in uniaxial slab waveguides (two interfaces). The resulting modes differ from conventional slab waveguide modes in that (1) they are composed entirely of inhomogeneous waves and (2) at most two of these modes can exist regardless of the waveguide thickness.
MEMS-SOA Tunable Optoelectronic Oscillator (2022)

We present a microelectromechanical system (MEMS) based tunable optoelectronic oscillator. The tunability of the frequency is accomplished by changing the free spectral range of MEMS-semiconductor optical amplifier (SOA) sliced broadband optical source in a microwave photonic filter configuration. Tuning range of 1.5 GHz is demonstrated, where the limitation is set by the electrical amplifier bandwidth. The phase noise at a frequency offset of 10 kHz is below 81 dBc/Hz while the side mode noise is measure around −52.37 dBc/Hz. The center wavelength and tuning range can be adapted to larger frequency ranges.
Differential genetic interactions of yeast stress response MAPK pathways - eScholarship (2015)

© 2015 The Authors.Abstract Genetic interaction screens have been applied with great success in several organisms to study gene function and the genetic architecture of the cell. However, most studies have been performed under optimal growth conditions eve
Acid-Catalyzed E-Ring Expansion and Isomerization of 3-Acetylbetulin: Synthesis of Cytotoxic Anhydrobetulin Saponins (2009)

22(17 → 28)abeo-Lupene derivatives 5a and 6a were obtained after the acid-catalyzed E-ring expansion of 3-acetylbetulin (1a). Glycosylation of these dehydrated triterpenoids using Schmidt's trichloroacetimidate sugar donors in the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) provided the new anhydrobetulin saponins 7b–7e in which the terminal olefin C-20(29) isomerizes to form a C-19 tetrasubstituted alkene. The preliminary cytotoxic evaluation revealed that saponins 7b–7d exhibited a moderate cytotoxic activity against A549, DLD-1, and WS1 human cell lines with IC50 ranging from 22 to 49 μM.
ChemInform Abstract: Highly Enantioselective Simmons—Smith Fluorocyclopropanation of Allylic Alcohols via the Halogen Scrambling Strategy of Zinc Carbenoids. (2013)

Abstract Excellent diastereoselectivities are achieved, except for the Z‐cinnamyl alcohol (IV) which gives the trans‐diastereomer (V) only with 4:1 d.r.
Chirped solitons as attractors for short light pulses (2004)

Nonlinear chirped pulse solutions are shown to exist as stable attractors for short light pulses in driven and damped systems. The attractors are determined for systems of different complexity, from simple gain and damping modelings up to the inclusion of higher-order dispersion, Raman processes, and delayed nonlinear responses. The chirped attractors, their stability, as well as the attractor basins can be determined analytically. The analytical predictions are in excellent agreement with numerical simulations.
TTK inhibition radiosensitizes basal-like breast cancer through impaired homologous recombination (2020)

Increased rates of locoregional recurrence are observed in patients with basal-like breast cancer (BC) despite the use of radiation therapy (RT); therefore, approaches that result in radiosensitization of basal-like BC are critically needed. Using patients' tumor gene expression data from 4 independent data sets, we correlated gene expression with recurrence to find genes significantly correlated with early recurrence after RT. The highest-ranked gene, TTK, was most highly expressed in basal-like BC across multiple data sets. Inhibition of TTK by both genetic and pharmacologic methods enhanced radiosensitivity in multiple basal-like cell lines. Radiosensitivity was mediated, at least in part, through persistent DNA damage after treatment with TTK inhibition and RT. Inhibition of TTK impaired homologous recombination (HR) and repair efficiency, but not nonhomologous end-joining, and decreased the formation of Rad51 foci. Reintroduction of wild-type TTK rescued both radioresistance and HR repair efficiency after TTK knockdown; however, reintroduction of kinase-dead TTK did not. In vivo, TTK inhibition combined with RT led to a significant decrease in tumor growth in both heterotopic and orthotopic, including patient-derived xenograft, BC models. These data support the rationale for clinical development of TTK inhibition as a radiosensitizing strategy for patients with basal-like BC, and efforts toward this end are currently underway.
EFFECT OF LIMB ORIENTATION AND TRACTION ON THE TENDON BONE INTERFACE (2003)

Surgeons often protect Tendon-bone reconstructions such as rotator cuff repairs by off loading them. We investigated the effect of limb position and boundary conditions in an in-vitro rabbit patella tendon-bone repair model. Patella tendons were repaired back to the tibia in eight hindlimb cadavers with 2 mitek anchors(Mitek, Westwood, MA) and 3-0 Ethibond (Ethicon, Sommerville, NJ) using two techniques, one involving simple sutures and the other involving crossing over between the sutures. A loading mechanism through the patella tendon was constructed using static weights over a pulley mechanism. The contact area and force at the PT-bone interface were measured using a TekScan pressure sensor (6911, TekScan, South Boston, MA). The contact footprint (area and normal force) was acquired under four configurations: (1) knee full extension with interface unloaded, (2) knee 45° flexion with interface unloaded, (3) knee full flexion with interface loaded by limb weight alone, (4) tendon loaded with limb weight and 20N force applied through tendon loading mechanism. The contact area force footprint changed substantially between the different suture techniques and loading configurations. Crossing over of sutures appears to provide an increased and more evenly distributed force across the tendon-bone interface. Repair off-loading was accompanied by a decrease in the contact footprint force and pressure. The force in both suture techniques increased with increasing flexion angle and was substantially increased by both bearing the weight of the dependent limb and by an axial load in the patellar tendon. Off loading a repair may not provide optimal environment for healing.
Gemini: an optical interconnection network for parallel processing (2002)

The Gemini interconnect is a dual technology (optical and electrical) interconnection network designed for use in tightly-coupled multicomputer systems. It consists of a circuit-switched optical data path in parallel with a packet-switched electrical control/data path. The optical path is used for transmission of long data messages and the electrical path is used for switch control and transmission of short data messages. The paper describes the architecture of the interconnection network and related communications protocols. Fairness issues associated with network operation are addressed and a discrete-event simulation model of the entire system is described. Network performance characteristics derived from the simulation model are presented. The results show significant performance benefits when using virtual output queuing and quantify the tradeoffs between throughput and fairness in the system.
Red cell proteins. I. Two-dimensional mapping of human erythrocyte lysate proteins (1979)

Human erythrocyte lysate proteins were resolved into over 250 discrete spots by two-dimensional electrophoresis using isoelectric focusing in the first dimension and electrophoresis in the presence of sodium dodecyl sulfate, (SDS) in the second. The overwhelming excess of hemoglobin has made such analyses difficult in the past. However, with the ISO-DALT two-dimensional electrophoresis system, large numbers of red cell proteins can be mapped in the presence of hemoglobin. When hemoglobin and several other major proteins are removed by adsorption to DEAE-cellulose, additional minor components are seen, giving a total of over 275. With the use of purified preparations, the map positions of five cell enzymes or their subunits were determined: pyruvate kinase, catalase, glucose-6-phosphate dehydrogenase, hypoxanthine phosphoribosyltransferase, and carbonic anhydrase. The mapping techniques described complement and extend those traditionally used to find human red cell protein variants.
Painting a rainbow on silicon – a simple method to generate a porous silicon band filter gradient (2005)

Abstract A band filter gradient structure was obtained in porous Si by electrochemically etching a rugate structure into a Si wafer using an asymmetrically placed counter electrode. The resulting porous Si film displays a rejection band whose wavelength maximum varies spatially due to the uneven distribution of current across the wafer during the etch. The rainbow‐like band filter can be converted to a porous SiO 2 graded band filter by thermal oxidization. A robust and flexible composite silicone/porous silicon gradient structure is achieved by impregnation with a silicone polymer. (© 2005 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Reduced Immunoglobulin A Transcytosis Associated with Immunoglobulin A Nephropathy and Nasopharyngeal Carcinoma (2011)

Polymeric IgA (pIgA) is transcytosed by the pIgA receptor (pIgR) across mucosal epithelial cells. After transcytosis to the apical surface, the extracellular, ligand-binding portion of the pIgR is proteolytically cleaved. A missense mutation in human pIgR, A580V, is associated with IgA nephropathy and nasopharyngeal carcinoma. We report that this mutation reduces the rate of transcytosis of pIgR and pIgA, and seemingly the rate of pIgR cleavage. We propose that the defects in pIgR trafficking caused by the A580V mutation may underlie the pathogenesis of both diseases.
Renovascular hypertension from the BCR‐ABL tyrosine kinase inhibitor ponatinib (2020)

Drug-induced hypertension is one of the commonest causes of secondary hypertension. In the last few years, secondary hypertension due to tyrosine kinase inhibitors, from the vascular endothelial growth factor class, has been recognized to be an important cause of hypertension, as well as proteinuria, and occasionally kidney dysfunction in some cases. Less well-recognized is that BCR-ABL tyrosine kinase inhibitors also have adverse vascular effects. These manifest as vascular stenoses in large vessels, which may sometimes cause renal artery stenosis and subsequent hypertension. We describe a case report which presented as classical bilateral renal artery stenosis, and responded to revascularization. Increased awareness of these effects, as well as research into the pathogenesis, may provide more insight into vascular biology.
Nonuniform structural degradation in porous organosilicate films exposed to plasma, etching, and ashing as characterized by x-ray porosimetry (2007)

X-ray porosimetry is used to characterize the porosity, the average film density, and the density of the wall material between the pores in ultralow-k films as a function of film thickness. These measurements are performed on films that have been plasma treated as well as plasma etched and an ashed to evaluate how these integration processes affect the pore characteristics of the interlayer dielectric. The damage, a decrease of porosity and an increase in the wall density, is strongly localized to the exposed surface of the film. The plasma etching and ashing tend to induce more surface damage than the plasma alone.
Clinicopathological Staging of Dynamics of Neurodegeneration and Neuronal Loss in Alzheimer Disease (2020)

Clinical and neuropathological staging of Alzheimer disease (AD) neurodegeneration and neuronal loss dynamics is the baseline for identification of treatment targets and timing. The aim of this study of 14 brain regions in 25 subjects diagnosed with AD and 13 age-matched control subjects was to establish the pattern of neurodegeneration, and the severity and rate of neuronal loss in mild cognitive impairment/mild AD (Functional Assessment Staging [FAST] test 3-4), moderate to moderately severe AD (FAST 5-6), and severe AD (FAST 7). The study revealed (1) the most severe neuronal loss in FAST 3-4; (2) the highest rate of neuronal loss in FAST 5-6, to the "critical" point limiting further increase in neuronal loss; (3) progression of neurofibrillary degeneration, but decline of neuronal loss to a floor level in FAST 7; and (4) structure-specific rate of neuronal loss caused by neurofibrillary degeneration and a large pool of neuronal loss caused by other mechanisms. This study defines a range and speed of progression of AD pathology and functional decline that might potentially be prevented by the arrest of neuronal loss, both related and unrelated to neurofibrillary degeneration, during the 9-year duration of mild cognitive impairment/mild AD.
Reagent‐specific underestimation of turoctocog alfa pegol (N8‐GP) clotting activity owing to decelerated activation by thrombin (2018)

Some contact activators reduce thrombin's ability to cleave N8-GP more than native FVIII. Decelerated thrombin activation of N8-GP is reflected in delayed FVIIIa-dependent appearance of FXa activity in plasma, in turn leading to prolonged clotting time. This forms the basis for underestimation of N8-GP activity as measured by one-stage clotting assay against a FVIII standard.
Application of the furan carbonyl photocycloaddition reaction to the synthesis of the bis(tetrahydrofuran) moiety of asteltoxin (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplication of the furan carbonyl photocycloaddition reaction to the synthesis of the bis(tetrahydrofuran) moiety of asteltoxinStuart L. Schreiber and Kunio SatakeCite this: J. Am. Chem. Soc. 1983, 105, 22, 6723–6724Publication Date (Print):October 1, 1983Publication History Published online1 May 2002Published inissue 1 October 1983https://pubs.acs.org/doi/10.1021/ja00360a035https://doi.org/10.1021/ja00360a035research-articleACS PublicationsRequest reuse permissionsArticle Views812Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Subcutaneous ω-Conotoxins Alleviate Mechanical Pain in Rodent Models of Acute Peripheral Neuropathy (2021)

The peripheral effects of ω-conotoxins, selective blockers of N-type voltage-gated calcium channels (Ca<sub>V</sub>2.2), have not been characterised across different clinically relevant pain models. This study examines the effects of locally administered ω-conotoxin MVIIA, GVIA, and CVIF on mechanical and thermal paw withdrawal threshold (PWT) in postsurgical pain (PSP), cisplatin-induced neuropathy (CisIPN), and oxaliplatin-induced neuropathy (OIPN) rodent models. Intraplantar injection of 300, 100 and 30 nM MVIIA significantly (<i>p</i> < 0.0001, <i>p</i> < 0.0001, and <i>p</i> < 0.05, respectively) alleviated mechanical allodynia of mice in PSP model compared to vehicle control group. Similarly, intraplantar injection of 300, 100, and 30 nM MVIIA (<i>p</i> < 0.0001, <i>p</i> < 0.01, and <i>p</i> < 0.05, respectively), and 300 nM and 100 nM GVIA (<i>p</i> < 0.0001 and <i>p</i> < 0.05, respectively) significantly increased mechanical thresholds of mice in OIPN model. The ED<sub>50</sub> of GVIA and MVIIA in OIPN was found to be 1.8 pmol/paw and 0.8 pmol/paw, respectively. However, none of the ω-conotoxins were effective in a mouse model of CisIPN. The intraplantar administration of 300 nM GVIA, MVIIA, and CVIF did not cause any locomotor side effects. The intraplantar administration of MVIIA can alleviate incision-induced mechanical allodynia, and GVIA and MVIIA effectively reduce OIPN associated mechanical pain, without locomotor side effects, in rodent models. In contrast, CVIF was inactive in these pain models, suggesting it is unable to block a subset of N-type voltage-gated calcium channels associated with nociceptors in the skin.
High-performance Marchand-type balun design and fabrication using an integrated passives device (IPD) technology (2008)

The integrated passive device (IPD) technology was currently developed for high performance, small volume or size, low cost and multi-functional integration for wireless RF front-end applications. Especially wafer level packaging technologies offer an interesting variety of different possibilities for the implementation of integrated passive components. The IPD process is made by a low-cost manufacturing technology and a high-performance process technology of electro-chemically forming spin coating layer on glass wafer and processing thick-Cu interconnects and polyimide dielectrics. In this paper, an integrated Marchand-type balun for 2.45-GHz WLAN applications is presented and exhibit excellent measured performance with insertion loss of 1 dB. The measured amplitude balance and phase balance of 0.45 dB and 3 degree, and common mode rejection ratio of 28 dB were realized. Finally, EM simulation and experimental verification show very good agreement between simulated and measured results by validating IPD design process.
Translational Careers (2009)

Powered by the computational muscle of bioinformatics and the broad perspective of systems biology, advances in biomedical science now have the capacity to transform medicine. Yet to fully realize the health benefits of new scientific insight, we must ensure a vibrant flow of information between the basic sciences and clinical medicine. This takes both systems and people.
Impairment Evaluation: Use of the Guides in Ontario for Defining “Catastrophic Impairment”: Challenges and Controversies (2007)

Abstract Several Canadian provinces use the AMA Guides to the Evaluation of Permanent Impairment ( AMA Guides ) to adjudicate workers’ compensation claims, and the Province of Ontario uses the AMA Guides, Fourth Edition, to adjudicate motor vehicle accident personal injury claims. This article focuses on controversies that have arisen in Ontario regarding how the AMA Guides is applied and shows some of the challenges that occur in quantifying psychological impairment. In 2004, the Ontario Superior Court found in the Desbiens v. Mordini trial that the AMA Guides did not provide any direct methodology for estimating percentage impairment in this unique circumstance that involved pre-existing paraplegia and subsequent dramatic loss of residual functions. The judge found that, using the information available, a whole person impairment (WPI) score of 40% could be derived, but Ontario requires a minimum 55% WPI before an individual qualifies for catastrophic impairment benefits. In view of the individual's circumstances and a psychologist's recommendation, the judge awarded an additional 25% WPI. The Ontario model has been interpreted to allow subjective complaints (symptoms) to be included in the impairment evaluation process, but this approach eliminates any expectation of objectivity. If a judicial system aims to force impairment percentages onto a situation that in fact does not warrant such ratings, it should not do so by an inappropriate application of the AMA Guides .
Enhanced Mechanical Strength, Flexibility, and Shape-Restoring Rate of a Drug-Eluting Shape-Memory Polymer by Incorporation of Supramolecular Cross-Linkers (2020)

The purpose of this study is to develop mechanically robust soybean oil and polycaprolactone (PC)-based drug-eluting shape memory polymers (SMPs) containing polyrotaxane (PRX) cross-linkers. Essentially, the dynamic PRX cross-linker-containing methacrylate group is introduced to increase the cross-linking density and flexibility of the SMP to overcome its mechanical limitations. It was confirmed that the elongation and cross-linking density of the PRX-incorporated SMP were increased by 2-4 times compared to neat SMP. In addition, those high mechanical properties of the PRX-incorporated SMP could be maintained after the degradation of the PC by the drug-eluting process.
Carrier diffusion measurements in InSb by the angular dependence of degenerate four-wave mixing (1985)

Studies of the angular dependence of cw degenerate four-wave mixing in n-type InSb have yielded a value for the diffusion length, l(D), of 60 +/- 2 microm. From this, the dependence of l(D) on photoexcited carrier concentration is calculated. A simple model has been developed to estimate the corresponding parallel-processing capabilities of semi-conductor-based, all-optical, parallel-processing digital computing systems.