gebhart/patrepeval huggingface dataset:
Expression of Cutaneous Beta-2 Adrenoceptors is similar in patients with complex regional pain syndrome and Pain-Free controls (2019)

Objective&#13;\n&#13;\nStudies in rodents suggest that cutaneous beta-2 adrenoceptors (β2-ARs) mediate inflammation and pain after tissue injury and that inflammation and peripheral nerve injury trigger increases in neuronal β2-AR expression. Hence, the aim of this study was to investigate the expression of β2-ARs on keratinocytes and dermal nerves in patients with complex regional pain syndrome (CRPS).&#13;\n&#13;\nDesign, Setting, and Subjects&#13;\n&#13;\nFifty-eight patients with CRPS were recruited for this study. In addition, skin biopsies were obtained from 13 pain-free women and three pain-free men of similar age and sex distribution as the patients.&#13;\n&#13;\nMethods&#13;\n&#13;\nQuantitative sensory tests for assessing sensitivity to pressure, pinprick, light touch, heat, and cold were administered, and skin biopsies were obtained from the affected and contralateral limbs. Skin biopsies were also obtained from a similar site on the dorsal hand or foot of pain-free controls. Immunohistochemistry and confocal microscopy were used to identify β2-ARs on keratinocytes, dermal nerves, and blood vessels in the skin samples.&#13;\n&#13;\nResults&#13;\n&#13;\nThe distribution of β2-ARs in keratinocytes and nerves was similar in the affected and contralateral limbs of patients and was similar for target cells in patients and controls. However, elevated β2-AR expression in reticular nerve bundles was associated with heightened sensitivity to heat pain.&#13;\n&#13;\nConclusions&#13;\n&#13;\nThese findings do not support a major role of cutaneous β2-ARs in CRPS. However, activation of neuronal β2-ARs may contribute to thermal hyperalgesia in a subgroup of patients. Whether activation of β2-ARs on keratinocytes mediates inflammation early in the course of CRPS requires further investigation.
Interference Management in the TV White Space (2010)

One of the challenging problems in achieving reliable operation in the TV white space is interference. In this paper, the spectrum sharing problem between heterogeneous networks that are not interoperable is considered. Several non-cooperative interference management techniques are developed and analyzed. A generalization of dynamic frequency selection (DFS) that uses multiple channels to exploit the spatial variation of the interference pattern is developed. The new algorithm achieves significant performance gains compared to conventional DFS. Performance of multi-antenna interference cancellation techniques is studied. An interesting result on the limited gain of successive interference cancellation in a specific interference scenario is discussed.
Selection and validation of reference genes for RT-qPCR analysis in potato under abiotic stress (2017)

The results indicated that <i>EF1α</i> and <i>sec3</i> were the most stably expressed genes in the potato under drought and osmotic stress conditions. This work will facilitate future work on gene expression studies in potato and also benefit other species of the <i>Solanaceae</i>, such as tomato.
Mannose receptor-targeted vaccines (2004)

Targeting antigens to endocytic receptors on professional antigen-presenting cells (APCs) represents an attractive strategy to enhance the efficacy of vaccines. Such APC-targeted vaccines have an exceptional ability to guide exogenous protein antigens into vesicles that efficiently process the antigen for major histocompatibility complex class I and class II presentation. Efficient targeting not only requires high specificity for the receptor that is abundantly expressed on the surface of APCs, but also the ability to be rapidly internalised and loaded into compartments that contain elements of the antigen-processing machinery. The mannose receptor (MR) and related C-type lectin receptors are particularly designed to sample antigens (self and non-self), much like pattern recognition receptors, to integrate the innate with adaptive immune responses. In fact, a variety of approaches involving delivery of antigens to the MR have demonstrated effective induction of potent cellular and humoral immune responses. Yet, although several lines of evidence in diverse experimental systems attest to the efficacy of targeted vaccine strategies, it is becoming increasingly clear that additional signals, such as those afforded by adjuvants, may be critical to elicit sustained immunity. Therefore, MR-targeted vaccines are likely to be most efficacious in vivo when combined with agents that elicit complementary activation signals. Certainly, a better understanding of the mechanism associated with the induction of immune responses as a result of targeting antigens to the MR, will be important in exploiting MR-targeted vaccines not only for mounting immune defenses against cancer and infectious disease, but also for specific induction of tolerance in the treatment of autoimmune disease.
Abstract P344: Nuclear Factor E2-related Factor 2 (nrf2) Causes Early Microvascular Endothelial Dysfunction and Increased Adma by Activation of the Cox2/tp Receptor Pathway in Mice Infused With Angiotensin II for Three Days (2017)

Background: Activation of Nrf2 by tert-buthylhydroquinone (tBHQ) prevents hypertension, oxidative stress, endothelial dysfunction and ADMA in mice infused with angiotensin II (Ang II) for 12 days. However, Nrf2 activation with bardoxolone methyl increased cardiovascular events in diabetic patients within one week. Since we found that tBHQ activated cyclooxygenase (COX)-2 within 3 days, we tested the hypothesis that short-term tBHQ administration to Ang II infused mice increases microvascular dysfunction via COX dependent of PGs and TxA 2 that activate thromboxane-prostanoid receptors (TP-Rs). Methods: Mesenteric resistance arterioles(MRAs)were isolated from mice infused for 3 days with ANG II (400 ng/kg/min) or vehicle and given oral tBHQ (0.1% of water) or vehicle (n=6 mice/group). Endothelial derived relaxation factor (EDRF) was assessed by a myograph and NO and ROS by RatioMaster TM . Results: Compared to vehicle, Ang II infused mice given tBHQ had increased (P&lt;0.05) conscious mean arterial pressure (135±6 vs 115±7 mmHg), urinary 8-Iso prostane (1.5±0.4 vs 1.1±0.2ng/mg creatinine), and decreased EDRF (17± 3 vs 23± 2%) and NO (0.23 ± 0.02 vs 0.35 ± 0.02 Δunits), and enhanced ( P&lt;0.05, ) cellular ROS (0.27 ± 0.02 vs 0.12 ± 0.03 Δunits), mitochondria ROS (0.24 ± 0.02 vs 0.1 ± 0.02 Δunit) and microvascular asymmetric dimethylarginine (ADMA, 77 ± 6 vs 55 ± 7 nmol/mg protein). All these effects of tBHQ were prevented in COX-1 knockout mice drinking parecoxib (COX-2 inhibitor) and in TPR and Nrf2 knockout mice. Conclusions: Activation of Nrf2 increases short term Ang II-induced increases in BP, oxidative stress, ADMA and endothelial dysfunction. These depend on signaling via COX 1 + 2 and TP receptors. Our studies reveal novel dual effects of Nrf2 in Ang II infused mice: increased BP, ROS, ADMA and endothelial dysfunction within 3 days secondary to activation of COX/TPR signaling follow by the opposite effects of Nrf2 on BP, ADMA and vascular function within 12 days. Therefore, blockade of COX-2/TPRs pathway during initiation of Nrf2 therapy may prevent the devastating early adverse effects that have prevented its use in hypertension or diabetes.
P797Effect of sodium channel blockade on the 3-dimensional substrate of atrial fibrillation: a simulation study (2018)

International audience
User participation and compliance in speech automated telecommunications applications (2002)

The paper reviews results from a number of field trials assessing speech recognition feasibility for telecommunications services. Several applications incorporating speech automation are explored: Directory Assistance Call Completion (DACC), partial speech automation of Directory Assistance (OSF-Operator Store and Forward), banking over the telephone (Money Talks) and partial speech automation of a customer calling center (PREVIU). The experimental results presented, were collected through Wizard-of-Oz experiments as feasibility precursors to speech recognition automation. Speech interfaces were clearly superior to Touch-Tone in one experiment (PREVIU), with caller participation increasing by 30%. In another experiment (Money Talks), speech recognition interfaces did not improve caller participation and, in fact, provided no advantages over Touch-Tone automation. A number of prompting strategies have been identified as advantageous in increasing caller participation and compliance in automated services. Ultimately, success with speech automated services will rely on identifying the services most suitable for speech automation and then carefully crafting the user interface.
Run-time generation of HPS microinstructions from a VAX instruction stream (1986)

The VAX architecture is a popular ISP architecture that has been implemented in several different technologies targeted to a wide range of performance specifications. However, it has been argued that the VAX has specific characteristics which preclude a very high performance implementation. We have developed a microarchitecture (HPS) which is specifically intended for implementing very high performance computing engines. Our model of execution is a restriction on fine granularity data flow. In this paper, we concentrate on one particular aspect of an HPS implementation of the VAX architecture: the generation of HPS microinstructions (i.e. data flow nodes) from a VAX instruction stream.
Wireless Remote Control [IP Corner] (2012)

The article "Channel surfing redux" [ibid., Vol 1, no 4, Oct 2012] about the coinventors of the original wireless remote control (RC) technologies was inspired as a tribute to the recent passing of Eugene Polley. Within the IEEE Consumer Electronics (CE) Society, we are lucky to have an IEEE Fellow and longtime volunteer within our Society who worked with both Polley and Robert Adler. Adler invented an alternative technology for wireless RC at almost the same time. It is perhaps not surprising that there was occasional conflict between the two, but both made a significant contribution to consumer electronics technology at that time, and this issue of IEEE Consumer Electronics Magazine is themed around their work. As a compliment to the main article on the history and background of the original television RC, the author investigates the technologies behind both Flash-Matic (Polley) and Space Command (Adler) RCs.
Synergistic Coating-Alloy Development for Harsh Environments (2022)

The primary objective of the work was to demonstrate model alloy-coating combinations with: A. Improved oxidation resistance with a barrier coating by at least 2x vs. uncoated alloy; B. Uniform coating on a greater than 100:1 aspect ratio structure; and C. Expected reduction of lifecycle cost of a component of >25% based on customer inputs. All three objectives have been achieved.
Combinatorial Aspects of Materials Science (2002)

This chapter contains sections titled: Introduction Combinatorial Solid-state Materials Science Materials Library Synthesis Vapor Deposition Techniques Alternative Library Synthesis Techniques High-throughput Screening Optical Screening X-Ray Characterization Applications Superconductivity Ferromagnetic Semiconductors Magnetoresistant Materials Dielectric and Ferroelectric Materials Luminescent Materials Case Studies Materials Discovery Device Optimization Organic Materials and Polymers Schiff Bases for Nonlinear Optical (NLO) Materials Artificial Receptors for Small Organic Molecules New Materials for the Separation of Enantiomers Molecular Imprinting Polymers with Novel Topologies and Functionalization Summary and Outlook Acknowledgments References
A positive tone plasma-developable resist obtained by gas-phase image reversal (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA positive tone plasma-developable resist obtained by gas-phase image reversalScott A. MacDonald, Hubert Schlosser, Nicholas J. Clecak, C. Grant Willson, and Jean M. J. FrechetCite this: Chem. Mater. 1992, 4, 6, 1364–1368Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/cm00024a043https://doi.org/10.1021/cm00024a043research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Two‐Photon Lithography of Sub‐Wavelength Metallic Structures in a Polymer Matrix (2010)

A novel method for fabricating metallic nanostructures with sub-wavelength resolution in a polymer using simultaneous two-photon initiated reduction of a metal salt and polymerization of a negative photoresist is demonstrated. Gold nanoparticle-doped lines as narrow as 200 nm were fabricated. The dependence of line-width on laser intensity and scan speed are captured well by an analytical model. We created functional gratings and planar chiral elements, characterized their optical properties, and modeled their electromagnetic response.
Bony Increased-Offset Reversed Shoulder Arthroplasty (BIO-RSA): Does the Graft Really Heal? (2013)

Introduction: Lateralization of reversed shoulder arthroplasty provides improvement in range of motion and decreases inferior scapular notching. The purpose of this study was to verify if the autologous cancelous bone graft harvested from the humeral head does heal constantly in a large cohort of patients followed for a long time Methods: Cohort of 92 consecutive patients operated between 2006 and 2010 with a BIORSA for definitive shoulder pseudoparalysis, secondary to cuff tear arthropathy (CTA) or massive, irreparable cuff tear (MCT). The autogenous cancelous graft was harvested from humeral head in all cases. Eight patients were lost for follow up, and four died before 2 years. The remaining 80 patients underwent clinical, radiographic and CT assessment at a minimum FU of 24 months. Mean age was 73 years. Three independent observers evaluated notching, partial or total glenoid or humeral loosening and viability of the graft. Constant-Murley score, range of motion and subjective shoulder value (SSV) were recorded. The mean follow up was 39 months (range 24–74 months). Results: The bone graft did healed completely in 96% of the cases (77/80); the thickness of the graft remained stable through the years. There were two cases of glenoid loosening: one nonunion of the graft at the scapular side was due to an important superior tilt of the glenosphere; one failure of fixation at the baseplate side was related to a low-grade infection. Another patient had a partial radiolucent line between graft and native glenoid located only above the central peg. No other radiolucent line around peg, screws or baseplate was found. Inferior scapula notching was observed in 19% of the cases (mainly grade 1 and 2). Each parameters of Constant score improved, and the mean SSV increased from 27% to 78%. Conclusion: This study shows that: (1) autologous cancellous bone graft, harvested from the humeral head, does heal to the native glenoid despite the advanced age of the patients; and (2) BIO-RSA allows improvement of shoulder function (mobility, pain, strength, subjective value) with a low rate of scapular notching.
Feasibility and indicator outcomes using computerized clinical decision support in pediatric traumatic brain injury anesthesia care (2019)

Use of clinical decision support in pediatric traumatic brain injury anesthesia care is feasible, reliable, and may have the potential to improve key performance indicator outcomes. This observational study suggests the possibility of clinical decision support as a strategy to reduce second insults and improve traumatic brain injury guideline adherence during pediatric anesthesia care.
The T-type calcium channel CaV3.2 regulates bladder afferent responses to mechanical stimuli (2022)

The bladder wall is innervated by a complex network of afferent nerves that detect bladder stretch during filling. Sensory signals, generated in response to distension, are relayed to the spinal cord and brain to evoke physiological and painful sensations and regulate urine storage and voiding. Hyperexcitability of these sensory pathways is a key component in the development of chronic bladder hypersensitivity disorders including interstitial cystitis/bladder pain syndrome and overactive bladder syndrome. Despite this, the full array of ion channels that regulate bladder afferent responses to mechanical stimuli have yet to be determined. Here, we investigated the role of low-voltage-activated T-type calcium (Ca V 3) channels in regulating bladder afferent responses to distension. Using single-cell reverse-transcription polymerase chain reaction and immunofluorescence, we revealed ubiquitous expression of Ca V 3.2, but not Ca V 3.1 or Ca V 3.3, in individual bladder-innervating dorsal root ganglia neurons. Pharmacological inhibition of Ca V 3.2 with TTA-A2 and ABT-639, selective blockers of T-type calcium channels, dose-dependently attenuated ex-vivo bladder afferent responses to distension in the absence of changes to muscle compliance. Further evaluation revealed that Ca V 3.2 blockers significantly inhibited both low- and high-threshold afferents, decreasing peak responses to distension, and delayed activation thresholds, thereby attenuating bladder afferent responses to both physiological and noxious distension. Nocifensive visceromotor responses to noxious bladder distension in vivo were also significantly reduced by inhibition of Ca V 3 with TTA-A2. Together, these data provide evidence of a major role for Ca V 3.2 in regulating bladder afferent responses to bladder distension and nociceptive signalling to the spinal cord.
High Frequency Strip-Type Solidly-Mounted Shear Mode Bulk Wave Resonator Using X-LT (2020)

The common materials of bulk acoustic wave (BAW) resonators are AlN and ScAlN. For a wider bandwidth, the Sc to Al ratio in ScAlN is increased up to 40%, but the Q factor often deteriorates and the impedance (Z) ratio does not improve significantly. For better filter performance, this study investigated monocrystalline LiTaO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (LT) as a piezoelectric material for a high frequency strip type thickness shear mode (TS) solidly mounted resonator (SMR). We selected the SMR instead of a film BAW resonator (FBAR) with a cavity, because the suspended ultrathin LT plate is fragile. The strip type TS mode SMR is composed of two Al electrodes, a 2.0 μm thick X LT plate, an Al electrode, eight layers of SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and Ta film (4+4 layers) and a 350 μm thick Si substrate from the top. The fabricated SMR shows a center frequency of 1 GHz, a bandwidth of 6.7% and an Z ratio of 62 dB. The temperature coefficients of frequency (TCF) at series and parallel resonance are as good as - 17 and -34 ppm/°C, respectively.
Análise de Utilização de Recursos Computacionais pelos Controladores SDN (2015)

Existem diversos estudos em que os controladores SDN são submetidos à sobrecarga de tráfego em diferentes cenários e suas respostas são analisadas em relação apenas à vazão da rede. Diferentemente, este artigo apresenta uma análise de desempenho de diversos controladores SDN observando o consumo de recursos das máquinas em que estão sendo executados.
How people recall search result lists (2006)

People commonly interact with lists of information -- incoming emails are listed in a person's Inbox, search engines return lists of results, news stories appear as lists on newspaper Web sites, and people navigate file systems by listing directory contents. While the changes that occur to a list can be interesting -- a new search result is interesting to the person searching for new information -- changes are often secondary to the primary goal of using information. New search results are inconsequential when a person wants to summarize a set of results or return to a previously viewed Web page. This paper presents a study of which aspects of a list are memorable and thus are likely to be noticed when they change, and which are not memorable and thus are unlikely to be missed if changed. The study shows that what people remember about a list item is a function of their interaction with the item and the item's location in the list.
Method for delivery of small molecules and proteins across the cell wall of algae using molecular transporters (2023)

The introduction of tools to study, control or expand the inner-workings of algae has been slow to develop. Provided are embodiments of a molecular method based on guanidinium-rich molecular transporters (GR-MoTrs) for bringing molecular cargos into algal cells. The methods of the disclosure have been shown to work in wild-type algae that have an intact cell wall. Developed using Chlamydomonas reinhardtii, this method is also successful with less studied algae, including Neochloris oleoabundans and Scenedesmus dimorphus, thus providing a new and versatile tool for algal research and modification. The method of delivering a cargo compound to an algal cell comprises contacting an algal cell with a guanidinium-rich delivery vehicle comprising a guanidinium-rich molecular transporter (GR-MoTr) linked to a cargo compound desired to be delivered to the algal cell, whereby the guanidinium-rich molecular transporter can traverse the algal cell wall, thereby delivering the cargo compound to the algal cell.
Oxide Based Supercapacitors I-Manganese Oxides (2017)

In this chapter, as the most promising candidate of electrodes for supercapacitors, manganese oxides, including MnOx, Mn3O4, Mn2O3, MnO2, are systematically discussed. Synthesis and characterization of manganese oxides, in forms of thin films and nanoparticles, are reviewed. Attempts have been made to establish interrelationships among synthetic processing, properties (such as oxidation state, morphology, particle size and size distribution) and electrochemical behaviours of the materials. Because their low conductive characteristics, it is natural to combine manganese oxides with various nanocarbons and conducting polymers to form hybrid nanostructures, which make full utilization of high electrical conductivity of these materials, so as to develop supercapacitors with higher energy storage capabilities.