gebhart/patrepeval huggingface dataset:
Influence of Sonication on Morphological Properties of Poly(Vinyl Acetate) Particles Produced Through Suspension Polymerization (2016)

Summary The use of polymers for various medical purposes has increased significantly over the past few years, including vascular embolization procedures. The main challenge in this particular case is the development of embolic agents with suitable properties in order to render the application safer and reproducible. In this context, particle density plays a fundamental role in vascular embolization performance, since off‐spec values can lead to undesired sedimentation of particles during the medical procedure. The influence of sonication power on the morphology of polymer particles produced through suspension polymerizations was investigated in the present work, as well as the effects of adding polymer material into the initial monomer dispersion on the final morphological properties of the product. It is shown in particular that the investigated morphological properties (density, shape, porosity) depend on the operation conditions on manners that have not been discussed in the literature.
The Molecular Basis of Lung Carcinogenesis (2002)

Lung cancer is the leading cause of cancer deaths in the Western world. According to the World Health Organization (WHO), lung cancer kills about 1 million people worldwide each year. in the United States in 1997, lung cancer accounted for 13% of new cancer cases, and 32% of cancer deaths in males and 17% of cancer deaths in females (1).
Velocity and Temperature Profiles for Laminar Magnetohydrodynamic Flow in the Entrance Region of a Plane Channel (1962)

The entry problem in plane laminar magnetohydrodynamic flow is solved numerically for various values of the pertinent parameters describing the flow. The channel configuration is a parallel-plate channel which has the Hartmann profile for its fully developed velocity flow. The equations are placed in a finite difference form to enable the essential nonlinearities of the principal equations to be used in the solution of the problem. Velocity, temperature, and pressure curves are presented from the results of computational work.
Editorial Comment (2009)

No AccessJournal of UrologyAdult Urology1 Nov 2009Editorial Comment Robert G. Uzzo Robert G. UzzoRobert G. Uzzo More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2009.07.111AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 182(5), p. 2171 References 1 : Percutaneous primary tumor biopsy is unreliable to predict high risk pathologic features in patients with metastatic renal cell carcinoma. J Urol2009; 181: 501. abstract 1401. Link, Google Scholar 2 : Prognostic nomograms for prediction of survival before or after cytoreductive nephrectomy for metastatic renal cell carcinoma. J Urol2009; 181: 499. abstract 1398. Link, Google Scholar Fox Chase Cancer Center, Philadelphia, Pennsylvania© 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 182Issue 5November 2009Page: 2171 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Robert G. Uzzo More articles by this author Expand All Advertisement PDF downloadLoading ...
PF178 DEFINITION OF REPRESENTATIVE BONE MARROW SAMPLE BASED ON PARALLEL EVALUATION OF PERIPHERAL BLOOD DURING THE THERAPY OF ACUTE LYMPHOBLASTIC LEUKEMIA (2019)

Background: Acute lymphoblastic leukemia (ALL) treatment leads to elimination of the blasts and subsequent regeneration of non‐malignant populations. Amount of minimal residual disease (MRD) is the strongest prognostic marker and its value differs between bone marrow (BM) and peripheral blood (PB). Therefore for patients stratification is necessary to evaluate non‐hemodiluted BM sample. Our AIEOP BFM 2009 protocol considers a BM sample non‐hemodiluted if &gt;2% of its cells are erythroid precursors (EP). EPs are defined as CD19neg(orCD7neg)CD45neg cells Aims: 1. To evaluate utility of the currently used marker of BM representativeness. 2. To define new, more exact approach for definition of representative BM. Methods: Patients (n = 528) diagnosed with ALL between 2007 and 2015 were included into the study. We analyzed proportion of EPs defined as CD19neg(orCD7neg)CD45neg in BM and in parallel also in PB at day 15 together with viability dye DAPI. We tested whether a new definition of EPs including an added CD71 marker (transferrin receptor expressed since early phases of erythropoiesis) improves its specificity. Then we evaluated other non‐malignant populations (n = 342) in BM and PB for the new definition of representative BM (lymphocytes, granulocytes, monocytes, erythroid precursors, mature B cells, T cells and NK cells in both B cell precursor and T ALL; CD4+, CD8+ and CD4negCD8neg T lymphocytes in T ALL only). Results: 1. We identified high proportion of apoptotic cells in EPs defined as CD19neg(orCD7neg)CD45neg (6.5–96%, median 55%) The population defined as CD19neg(orCD7neg)CD45negCD71pos was more viable (apoptotic cells 0–66%, median 9%) p &lt; 0.0001. Then we evaluated population CD19neg(orCD7neg)CD45neg in PB. We found that as many as 29% of PB samples have &gt;2% of EP (the value that is currently used as a marker of BM without hemodilution). 2. We defined a new assessment of BM representativeness based on comparison of non‐malignant populations between BM and PB. With increasing difference between the proportion of any population between BM and PB, the possibility of hemodilution lowers. According to this approach we can calculate maximal possible hemodilution and its influence on stratification of the patient. We evaluated 342 patients with available paired BM‐PB samples and identified 6 patients with highly hemodiluted BM samples who might have been misstratified. Summary/Conclusion: We defined a new, more accurate approach for assessment of BM representativeness by comparison of non‐malignant populations between PB and BM. By this approach we can exclude hemodilution in majority of the samples. The currently used marker of representativeness – proportion of EPs, defined as CD19neg(orCD7neg)CD45neg – is not sufficient for assessment of BM representativeness. If proportion of EPs is required, CD71 should be added for the definition. Supported by grants NV18–03–00343, NV18–07–00430 and LO1604.
Continuous‐Flow Synthesis of Biaryls Enabled by Multistep Solid‐Handling in a Lithiation/Borylation/Suzuki–Miyaura Cross‐Coupling Sequence (2011)

Let it flow: An efficient and modular synthesis of biaryls under continuous-flow conditions has been realized by a lithiation/borylation/Suzuki–Miyaura cross-coupling sequence under ambient conditions. Aryl bromides and heteroaromatic precursors can be transformed in the room-temperature lithiation reaction with nBuLi, followed by borylation and Suzuki–Miyaura coupling with the aid of ultrasonic irradiation (see scheme). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Pervasive Video and Audio (2021)

The articles in this special section focus on pervasive video and audio. For a long time, cameras and microphones have been studied to give machines the ability to see and hear the world around them. The remarkable progress in artificial intelligence (AI) in recent years has pushed this perception ability to a new high. AI-enabled cameras and microphones are now able to replicate human-like reasoning and cognition, be it detecting cancers better than a human doctor, identifying people’s sexual orientation, or understanding human speech. Naturally, these interminable possibilities across a wide range of verticals, ranging from public safety, infrastructure efficiency, entertainment, education, and health, have led to the deployment of billions of cameras and microphones around us—in our homes, workplaces, and cities.
Autonomic Resource Management for Program Orchestration in Large-Scale Data Analysis (2017)

Large-scale data analysis applications are becoming more and more prevalent in a wide variety of areas. These applications are composed of many currently available programs called analysis components. Thousands of analysis component processes are orchestrated on many compute nodes. This paper proposes a novel self-tuning framework for optimizing an application's throughput in large-scale data analysis. One challenge is developing efficient orchestration that takes into account the diversity of analysis components and the varying performances of compute nodes. In our previous work, we achieved such an orchestration to a certain degree by introducing our own middleware, which wraps each analysis component as a remote procedure call (RPC) service. The middleware also pools the processes to reduce startup overhead, which is a serious obstacle to achieving high throughput. This work tackles the remaining task of tuning the size of the analysis components' process pools to maximize the application's throughput. This is challenging because analysis components differ drastically in turnaround times and memory footprints. The size of the process pool for each type of analysis component should be set by giving consideration to these properties as well as the constraints on both the memory capacity and the processor core counts. In this work, we formulate this task as a linear programming problem and obtain the optimal pool sizes by solving it. Compared to our previous work, we significantly improved the scalability of our framework by reformulating the performance model to work on hundreds of heterogeneous nodes. We also extended the service allocation mechanism to manage the computational load on each compute node and reduce communication overhead. The experimental results show that our approach is scalable to thousands of analysis component processes running on 200 compute nodes across three clusters. Moreover, our approach significantly reduces memory footprint.
I saw this and thought of you (2005)

This paper presents aspects of a study into how and why people use camera phones. The study examined people's intentions at the time of image capture and subsequent patterns of use. Motivated by current interest in "picture messaging", we focus on images taken to communicate with absent people and look at how they were actually used. We consider the timeliness of communication and the role of common ground to derive implications for design.
Synthesis of 4-Substituted 3,3-Difluoropiperidines (2010)

Synthetic strategies toward 4-substituted 3,3-difluoropiperidines were evaluated. 4-Alkoxymethyl- and 4-aryloxymethyl-3,3-difluoropiperidines were synthesized via 1,4-addition of ethyl bromodifluoroacetate to 3-substituted acrylonitriles in the presence of copper powder, followed by borane reduction of the cyano substituent, lactamization, and reduction of the lactam. This method was applied to establish the synthesis of N-protected 3,3-difluoroisonipecotic acid, a fluorinated gamma-amino acid. 4-Benzyloxy-3,3-difluoropiperidine was prepared using an analogous methodology and was converted to N-protected 3,3-difluoro-4,4-dihydroxypiperidine, a compound with high potential as a building block in medicinal chemistry.
ELECTRICAL PROPERTIES OF DOMAIN BOUNDARY IN PHOTOCONDUCTIVE SMECTIC MESOPHASES AND THEIR CRYSTAL PHASES (2001)

Abstract We have investigated the charge transport properties in smectic photoconductive liquid crystal of 2-phenylnaphthalene derivatives in focus on the electrical nature of the boundaries at the phase transition from liquid crystalline phase into the crystal phase. With systematic studies of charge transport and collection by transient photocurrent measurements and molecular alignment by X-ray diffraction at the phase transition, it was revealed that the defective nature of the crystalline boundaries takes the shape of shallow traps at the initial stage and of deep traps successively, and finally the polydomain allowance for the carrier transport in mesophases disappears completely when the phase transition takes place into the crystalline phases.
Cover Picture: Protein‐Structure‐Based Prediction of Animal Model Suitability for Pharmacodynamic Studies of Subtype‐Selective Estrogens (ChemMedChem 11/2006) (2006)

The cover picture shows a model of the binding pocket of the estrogen receptor (ER) occupied by 8β‐VE 2 , a steroidal ERβ‐selective agonist. As illustrated by the model, a single amino acid, methionine, accounts for the ERβ selectivity of this compound class. An exchange to leucine at this position in some animal species, depicted in the sequence alignment, generates unfavorable interactions with 8β‐VE 2 . Therefore, knowledge about the structure of the protein–ligand complex can be used to predict suitable animal models for in vivo pharmacological studies with this ligand class. For more details, see the Full Paper by L. Toschi et al. on p. 1237 ff.
Ultra low power consuming thermally stable sulphide materials for resistive and phase change memristive application (2012)

The use of conventional chalcogenide alloys in rewritable optical disks and the latest generation of electronic memories (phase change and nano-ionic memories) has provided clear commercial and technological advances for the field of data storage, by virtue of the many well-known attributes, in particular scaling, cycling endurance and speed, that these chalcogenide materials offer. While the switching power and current consumption of established germanium antimony telluride based phase change memory cells are a major factor in chip design in real world applications, the thermal stability and high on-state power consumption of these device can be a major obstacle in the path to full commercialization. In this work we describe our research in material discovery and prototype device fabrication and characterization, which through high throughput screening has demonstrated thermally stable, low current consuming chalcogenides for applications in PCRAM and oxygen doped chalcogenides for RRAM which significantly outperform the current contenders.
ChemInform Abstract: Regiospecific Bromination of 3‐Methylindoles with N‐Bromosuccinimide. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Targeting telomeric RNA quadruplexes (2009)

Thermodynamic data, specifically enthalpy (H) and entropy (S), reveal the forces that drive complex formation. Furthermore, binding affinity -K d in range of millimolar to nanomolar is a powerful information for drug design targeting highly homologous kinases. Supported with computational analysis, these data show the specific contributions of some important residues in ligand-binding, and lead to design a potent inhibitor.
HIVR4P 2016, Partnering for Prevention: Conference Summary and Highlights (2017)

HIV Research for Prevention: AIDS Vaccine, Microbicide, and ARV-based Prevention Science (HIVR4P) was built on a growing consensus that effective HIV prevention requires a combination of approaches and that understanding, analyzing, and debating the cross-cutting issues that impact prevention research are all essential to combat the global HIV/AIDS epidemic. To that end, the biennial HIVR4P conference is dedicated to all biomedical HIV prevention research approaches, including HIV vaccines, microbicides, pre-exposure prophylaxis, and treatment as prevention. The HIVR4P 2016 conference was held in Chicago, Illinois (USA), on October 17-21, and included more than 700 scientific presentations and 21 satellite sessions covering the latest and most promising advances across the HIV prevention research field. The theme "Partnering for Prevention" represented the conference's commitment to breaking down silos between research disciplines as well as between researchers, program developers, care providers, advocates, communities, and funders. Delegates spanning 42 countries attended the conference. One-third of those in attendance were early career investigators, which reflects a firm commitment to emerging researchers and ultimately to the goal of developing a sustainable scientific enterprise well into the future. This article presents a concise summary of highlights from the conference. For a more detailed account, one may find full abstracts, daily summaries, and webcasts on the conference website at hivr4p.org.
Humoral Immune Response following Seasonal Influenza Vaccine in Islet Transplant Recipients (2012)

Annual influenza vaccine is recommended for organ transplant recipients, but immunogenicity is known to be suboptimal. Islet transplant recipients receive immunosuppressive therapy, but there are no data on the immunogenicity of influenza vaccine in this population. In this prospective cohort study, adult islet transplant recipients at least 3 months posttransplant were enrolled. All patients received the 2010-2011 seasonal influenza vaccine. Serum was obtained pre- and postvaccination to determine humoral response to each of the three influenza strains included in the vaccine. Adverse effects of vaccine were also noted. A total of 61 islet transplant recipients were enrolled and completed the study protocol. The median time from last transplant was 1.9 years (range 0.26-11.4 years), and most patients had undergone multiple prior islet transplant procedures (90.2%). Overall immunogenicity of the vaccine was poor. Seroconversion rates to H1N1, H3N2, and B antigens were 34.4%, 29.5%, and 9.8%, respectively. In the subset not seroprotected at baseline, a protective antibody titer postvaccination was achieved in 58.6%, 41.9%, and 34.5% of patients, respectively. Patients within the first year of transplant were significantly less likely to seroconvert to at least one antigen (23.5% vs. 54.5%; p = 0.029). Alemtuzumab recipients trended toward lower seroconversion rates (25% vs. 51%; p = 0.11). No vaccine-related safety concerns were identified. Seasonal influenza vaccine had suboptimal immunogenicity in islet transplant recipients especially those who were less than 1 year posttransplant or had received alemtuzumab induction. Novel strategies for protection in this group of patients need further study.
New broadband ELF receiver for studying atmospheric discharges in central Europe (2018)

We designed a new broadband extremely low frequency receiver and a set of two active magnetic antennas. The antennas cover the frequency range of 0.01 to 900 Hz. The receiver's front end makes use of a Bessel anti-aliasing filter with the energy bandwidth of 900 Hz, which enables us to record undistorted waveforms of impulsive signals associated with lightning. In this paper, we present the design of our system and the results of our first measurement campaign.
ChemInform Abstract: Use of Polymer‐Supported Thiophenol for the Synthesis and Purification of a Benzimidazol‐2‐one Library. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Symbols for communication circuit design and documentation (1988)

A set of communication symbols has been developed at Sandia National Laboratories for designing and documenting communication circuits. The symbols can depict devices in a circuit, show proper interfacing of devices, and show the propagation of clocks, data, and control signals through the circuit. This paper defines the communication symbols and illustrates their usage. 3 refs., 6 figs.
High-power blue generation from a periodically poled MgO:LiNbO3 ridge-type waveguide by frequency doubling of a diode end-pumped Nd:Y3Al5O12 laser (2003)

Continuous-wave power of 189 mW at 473 nm with 49% conversion efficiency is generated from a 8.5 mm long uncoated periodically polled MgO:LiNbO3 ridge-type waveguide by frequency doubling of a diode end-pumped Nd:Y3Al5O12 laser at room temperature; the corresponding internal blue power and conversion efficiency were 222 mW and 58%, respectively. The highest conversion efficiency of 63% (74% with respect to the blue internal power) was obtained from a 12 mm long waveguide with 99 mW blue output power. Saturation of output blue power was observed for coupled fundamental power into the waveguides in excess of 200 mW.
Supplementary Table 7 from TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia (2023)

&lt;p&gt;XLSX file - 61K, Gene expression profile after TYK2 and STAT1 knockdown in JURKAT cells. See separate file.&lt;/p&gt;
Network component analysis of Saccharamyces cerevisiae stress response (2005)

A method, network component analysis, was developed for uncovering hidden regulatory signals from outputs of networked systems, when only partial knowledge of the underlying network topology is available. This method was successfully applied to microarray data of yeast Saccharamyces cerevisiae under various stress conditions. The activities of 96 transcription factors were determined, which differ significantly from their gene expression patterns.
Macular Ganglion Cell and Inner Plexiform Layer Thickness Is More Strongly Associated With Visual Function in Multiple Sclerosis Than Bruch Membrane Opening–Minimum Rim Width or Peripapillary Retinal Nerve Fiber Layer Thicknesses (2019)

BMO-MRW and pRNFL thicknesses are reduced and associated with VF and disability in MS, but GCIPL thickness is a stronger marker of visual impairment. Our findings corroborate the utility of OCT in providing valuable information regarding the MS disease process.
ChemInform Abstract: PHOTOFRAGMENT FLUORESCENCE POLARIZATION FOLLOWING PHOTOLYSIS OF MERCURY(II) BROMIDE AT 193 NM (1980)

Abstract Wenn HgBrz (2‐45 mTorr) durch die linear polarisierte Strahlung eines ArF‐Exzimerenlasers (193 nm) einer Photolyse unterworfen wird, so ist die sichtbare Emission des HgBr‐Fragments linear polarisiert.
Linear Conjugated Polymers for Solar-Driven Hydrogen Peroxide Production: The Importance of Catalyst Stability (2021)

Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is one of the most important industrial oxidants. In principle, photocatalytic H<sub>2</sub>O<sub>2</sub> synthesis from oxygen and H<sub>2</sub>O using sunlight could provide a cleaner alternative route to the current anthraquinone process. Recently, conjugated organic materials have been studied as photocatalysts for solar fuels synthesis because they offer synthetic tunability over a large chemical space. Here, we used high-throughput experiments to discover a linear conjugated polymer, poly(3-4-ethynylphenyl)ethynyl)pyridine (DE7), which exhibits efficient photocatalytic H<sub>2</sub>O<sub>2</sub> production from H<sub>2</sub>O and O<sub>2</sub> under visible light illumination for periods of up to 10 h or so. The apparent quantum yield was 8.7% at 420 nm. Mechanistic investigations showed that the H<sub>2</sub>O<sub>2</sub> was produced via the photoinduced stepwise reduction of O<sub>2</sub>. At longer photolysis times, however, this catalyst decomposed, suggesting a need to focus the photostability of organic photocatalysts, as well as the initial catalytic production rates.
DISCIPLINE «COMPUTER GRAPHICS» (2015)

Описаны занятия по учебной дисциплине «Компьютерная графика» в МГТУ им. Н.Э. Баумана. Рассмотрено содержание учебных модулей. Выделена стратегия построения электронных геометрических моделей деталей.