gebhart/patrepeval huggingface dataset:
The evolution of cell lineage in nematodes (1994)

The invariant development of free-living nematodes combined with the extensive knowledge of Caenorhabditis elegans developmental biology provides an experimental system for an analysis of the evolution of developmental mechanisms. We have collected a number of new nematode species from soil samples. Most are easily cultured and their development can be analyzed at the level of individual cells using techniques standard to Caenorhabditis. So far, we have focused on differences in the development of the vulva among species of the families Rhabditidae and Panagrolaimidae. Preceding vulval development, twelve Pn cells migrate into the ventral cord and divide to produce posterior daughters [Pn.p cells] whose fates vary in a position specific manner [from P1.p anterior to P12.p posterior]. In C. elegans hermaphrodites, P(3-8).p are tripotent and form an equivalence group. These cells can express either of two vulval fates (1 degree or 2 degrees) in response to a signal from the anchor cell of the somatic gonad, or a nonvulval fate (3 degrees), resulting in a 3 degrees-3 degrees-2 degrees-1 degree-2 degrees-3 degrees pattern of cell fates. Evolutionary differences in vulval development include the number of cells in the vulval equivalence group, the number of 1 degree cells, the number of progeny generated by each vulval precursor cell, and the position of VPCs before morphogenesis. Examples of three Rhabditidae genera have a posterior vulva in the position of P9-P11 ectoblasts. In Cruznema tripartitum, P(5-7).p form the vulva as in Caenorhabditis, but they migrate posteriorly before dividing. Induction occurs after the gonad grows posteriorly to the position of P(5-7).p cells. In two other species, Mesorhabditis sp. PS 1179 and Teratorhabditis palmarum, we have found changes in induction and competence with respect to their presumably more C. elegans-like ancestor. In Mesorhabditis, P(5-7).p form the vulva after migrating to a posterior position. However, the gonad is not required to specify the pattern of cell fates 3 degrees-2 degrees-1 degree-2 degrees-3 degrees. Moreover, the Pn.p cells are not equivalent in their potentials to form the vulva. A regulatory constraint in this family thus forces the same set of precursors to generate the vulva, rather than more appropriately positioned Pn.p cells.
Patterns of response and relapse in primary CNS lymphomas after first-line chemotherapy: imaging analysis of the ANOCEF-GOELAMS prospective randomized trial (2016)

Baseline tumor size and infratentorial localization are of prognostic value in PCNSL. Our findings provide evidence that non-enhancing FLAIR abnormalities may add to overall tumor burden, suggesting that response criteria should be refined to incorporate evaluation of T2-weighted/FLAIR sequences.
Anterior Decompression for Late Pain and Paralysis After Fractures of the Thoracolumbar Spine (1994)

Anterior decompression of the thoracic and lumbar spine is indicated for patients with trauma, infection, or tumor that causes compression of the neural tissues, resulting in an incomplete neurologic deficit. The complication of chronic pain, with or without paralysis, that results from fractures with canal compromise has received little attention. This study involved 45 patients who had anterior decompression for chronic pain or paralysis at an average of 4.5 years after having thoracolumbar fractures. Pain was improved in 41 of 45 patients, with complete relief in 30 and partial relief in 11. In 25 patients with neurologic deficit, 21 noted improvement, 14 of which improved one or more grades of the Eismont classification. No patient had an increase in pain or loss of neurologic function. Complications were few. Anterior decompression of the thoracolumbar spine for chronic pain after thoracolumbar fractures is a safe and effective treatment for patients with this uncommon and difficult problem.
ChemInform Abstract: Sonochemical and Microwave‐Assisted Preparations of PbTe and PbSe. A Comparative Study. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Reverberation reduction by sub-band unmasking (2002)

Reverberation reduces the intelligibility of speech recorded in rooms. Signal processing algorithms attempt to reduce this reverberation such that the speech not only sounds less reverberant, but is more intelligible. Historically, these techniques are based on calculations of the room impulse response, on arrays of two or more microphones, noise cancellation, or cepstral techniques. The new technique assumes that the intelligibility loss is due to overlap masking of reverberant tails of speech. The algorithm looks at sub-bands and identifies those that mask adjacent bands. When this occurs in conjunction with a decaying envelope the decay rate is increased. Thus, the masked band has a greater chance of being heard. Intelligibility results for the processed speech will be presented.
Electrophysiologic Effects of Selective Right versus Left Atrial Linear Lesions in a Canine Model of Chronic Atrial Fibrillation (1999)

Left atrial linear lesions affect right atrial endocardial activation, whereas right atrial lesions do not affect left atrial activation in a canine model of atrial fibrillation. These findings suggest that the left atrium is the driver during chronic atrial fibrillation in this animal model and may explain the limited success of right atrial ablation alone in human atrial fibrillation.
ChemInform Abstract: New Generation Dopaminergic Agents. Part 7. Heterocyclic Bioisosteres that Exploit the 3‐OH‐Phenoxyethylamine D2 Template. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Next generation network management technology (1995)

Today’s telecommunications networks are becoming increasingly large, complex, mission critical and heterogeneous in several dimensions. For example, the underlying physical transmission facilities of a given network may be ‘‘mixed media’’ (copper, fiber‐optic, radio, and satellite); the subnetworks may be acquired from different vendors due to economic, performance, or general availability reasons; the information being transmitted over the network may be ‘‘multimedia’’ (video, data, voice, and images) and, finally, varying performance criteria may be imposed e.g., data transfer may require high throughput while the others, whose concern is voice communications, may require low call blocking probability. For these reasons, future telecommunications networks are expected to be highly complex in their services and operations. Due to this growing complexity and the disparity among management systems for individual sub‐networks, efficient network management systems have become critical to the current and future success of telecommunications companies. This paper addresses a research and development effort which focuses on prototyping configuration management, since that is the central process of network management and all other network management functions must be built upon it. Our prototype incorporates ergonomically designed graphical user interfaces tailored to the network configuration management subsystem and to the proposed advanced object‐oriented database structure. The resulting design concept follows open standards such as Open Systems Interconnection (OSI) and incorporates object oriented programming methodology to associate data with functions, permit customization, and provide an open architecture environment.
Effect of Al Content on r-Value and Recrystallization Texture of B-Bearing Al-Killed Steel Sheets (1998)

It has been demonstrated that boron (B) had a beneficial effect on the mechanical properties of continuously annealed Al-killed steel sheets. However, the effect of Al content on r-value in the B-bearing steels has not been well discussed yet. In this study, the effect of Al content on r-value and recrystallization texture formation was investigated for laboratory-melt B-bearing low C Al-killed steel sheets. The r-value of continuously annealed B-bearing steel increased with decreasing Al content under the same grain size. In the steels with lower Al (Al=0.005%) content, the carbide coarsening in hot-rolled sheet was more significant as compared to those with higher Al (Al=0.055%) content. The recrystallization temperature was lowered with decreasing Al content, and the development of //ND components was accelerated while that of //ND components was retarded. Since the increase in Al content accelerates AIN precipitation in hot-rolled sheets, B might remain as in solution and segregate to grain boundaries. On the other hand, the reduction in Al content causes preferential precipitation of BN in hot-rolled sheets. The improvement of r-value by reducing Al content in B-bearing low C steels was caused by the development of //ND components which reduced by solute B.
Enhancement of Interferon-mediated Protein Kinase in Mouse and Human Plasma in Response to Treatment with Polyadenylic–Polyuridylic Acid (Poly A:Poly U) (1982)

Interferon-treated mouse and human cells show enhanced levels of kinase activity manifested by the phosphorylation of endogenous 67,000 (p67K kinase) and 72,000 (p72K kinase) molecular weight proteins, respectively. Both the p67K kinase and the p72K activities are detectable in mouse and human plasma. We have previously shown that the p67K kinase in the plasma of mice may serve as a marker for the presence and action of interferon. Here we show that these kinase activities are enhanced in mice and in patients treated with polyadenylic-polyuridylic acid (Poly A:Poly U) at doses (0.4-0.6 mg/kg body weight) which do not lead to detectable amount of circulating interferon. Mice injected with higher doses of Poly A:Poly U (2-10 mg/kg body weight) show detectable levels of circulating interferon in addition to enhanced levels of p67K kinase in their plasma. Interferon produced under these conditions is acid stable.
The Clostridium ramosum IgA Proteinase Represents a Novel Type of Metalloendopeptidase (2002)

Clostridium ramosum is part of the normal flora in the human intestine. Some strains produce an IgA proteinase that specifically cleaves human IgA1 and the IgA2m(1) allotype. This prolylendopeptidase was purified from a broth culture supernatant, and N-terminal sequences of the native protein and tryptic fragments thereof were determined. A fragment of the iga gene encoding the IgA proteinase was isolated using degenerate primers in PCR, and the complete gene was obtained by inverse PCR. The identity of the iga gene was confirmed by heterologous expression in Escherichia coli. The deduced amino acid sequence indicated a signal peptide of 30 residues and a secreted proteinase of 133,828 Da. A typical Gram-positive cell wall anchor motif was identified in the C terminus. The presence of a putative zinc-binding motif His-Glu-Phe-Gly-His together with inhibition studies indicate that the proteinase belongs to the zinc-dependent metalloproteinases. However, the sequence of the C. ramosum IgA proteinase shows no overall similarity to other proteins except for significant identity around the zinc-binding motif with family M6 of metalloendopeptidases, and the unique sequence of the IgA proteinase in this area presumably establishes a new subfamily. The GC percentage of the iga gene is significantly higher than that for the entire genome of C. ramosum, suggesting that the gene was acquired recently in evolution.
Relationships Between Microstructural Parameters and Time‐Dependent Mechanical Properties of a New Nickel Based Superalloy AD730™ (2016)

This chapter contains sections titled: Introduction Experiment Procedure Result Discussion Conclusion Acknowledgments
Long-term chemothermal stability of delithiated NCA in polymer solid-state batteries (2019)

Changes in nickel oxidation state of chemically delithiated Li<sub>0.3</sub>Ni<sub>0.8</sub>Co<sub>0.15</sub>Al<sub>0.05</sub>O<sub>2</sub> (NCA) in bulk and surface after 35 days @ 80 °C are strongly depending on the type of polymer and lithium salt in the catholyte matrix.
Primitive quiescent CD34+ cells in chronic myeloid leukemia are targeted by in vitro expanded natural killer cells, which are functionally enhanced by bortezomib (2008)

Primitive quiescent CD34(+) chronic myeloid leukemia (CML) cells are more biologically resistant to tyrosine kinase inhibitors than their cycling counterparts; however, graft-versus-leukemia (GVL) effects after allogeneic stem cell transplantation (SCT) probably eliminate even these quiescent cells in long-term surviving CML transplant recipients. We studied the progeny of CD34(+) cells from CML patients before SCT, which were cultured 4 days in serum-free media with hematopoietic growth factors. BCR-ABL expression was similar in both cycling and quiescent noncycling CD34(+) populations. Quiescent CD34(+) cells from CML patients were less susceptible than their cycling CD34(+) and CD34(-) counterparts to lysis by natural killer (NK) cells from their HLA-identical sibling donors. Compared with cycling populations, quiescent CD34(+) CML cells had higher surface expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors DR4 and DR5. Bortezomib up-regulated TRAIL receptor expression on quiescent CD34(+) CML cells, and further enhanced their susceptibility to cytotoxicity by in vitro expanded donor NK cells. These results suggest that donor-derived NK cell-mediated GVL effects may be improved by sensitizing residual quiescent CML cells to NK-cell cytotoxicity after SCT. Such treatment, as an adjunct to donor lymphocyte infusions and pharmacologic therapy, may reduce the risk of relapse in CML patients who require treatment by SCT.
Mobility with a lower limb prosthesis: experiences of users with high levels of functional ability (2020)

Identified themes inform clinician and researcher understanding of mobility in highly active lower limb prosthesis users. The results of this study will be used to inform development of high-activity items for the PLUS-M item bank.Implications for rehabilitationParticipants described engagement in high-level activities as a learning process that included elements such as equipment challenges and modifications, pain and injury, and the need to trust the prosthetic limb.Participants with lower limb amputation who use prostheses identified mobility characteristics, such as postural changes, terrain, and obstacles, that influenced their ability to perform high-level activities.High-level mobility characteristics identified in these focus groups can be integrated into a revised version of the Prosthetic Limb Users Survey of Mobility to assess mobility in active adults and athletes with amputation.Rehabilitation professionals play an important role in facilitating access to specialized prosthetic components and training that can help patients achieve their mobility goals and potential.
Inhibition of the mixed lymphocyte reaction by T cell vaccination (1990)

Immunization with attenuated activated autoreactive T cell lines and clones induces a response in syngeneic animals which can induce protection or recovery from autoimmune disease. This process has been termed T cell vaccination. The aim of the present study was to investigate the effect of immunization with MHC-reactive T cells on the mixed lymphocyte reaction (MLR). By injecting attenuated activated T cells primed for an alloantigen, we markedly reduced the MLR in both rats and mice. This depression appeared to be mediated by active suppression; lymphoid cells from T cell-vaccinated animals suppressed the MLR responsiveness of T cells from naive animals. Suppression of the MLR was not restricted to the major histocompatibility complex (MHC) alleles used to prime the animals from which the T cell vaccines were prepared; the MLR to other MHC allelic stimulator cells was also suppressed. This MHC-unrestricted suppression could not be attributed to an anti-ergotypic response to non-MHC-linked activation markers on T cells; an anti-ergotypic response augmented rather than suppressed the MLR. We herein propose that T cell vaccination might influence the MLR by suppressing the responses of diverse T cells which bear shared T cell receptor idiotypes.
Effect of Mg insertion on time‐dependent dielectric breakdown in MgO‐based magnetic tunnel junctions (2016)

The stress‐induced breakdown characteristics in magnesium oxide (MgO)‐based magnetic tunnel junctions (MTJs) including an inserted Mg layer 0.5 nm thick is investigated, above or below an MgO tunnel barrier. Regardless of the insertion position, the inserted layer suppressed the time‐dependent dielectric breakdown (TDDB) observed in the case of electron tunnelling into the Mg‐inserted interface. This indicates that the Mg insertion significantly suppressed trap site formation at the anode‐side barrier/electrode interface. The improvement of TDDB by the Mg insertion was confirmed through constant voltage stress experiments. Therefore, interface modification by means of inserting an ultra‐thin metallic layer is highly effective in improving the reliability of an MTJ tunnel barrier for practical applications.
Supplementary Table 5 from A Cell Proliferation and Chromosomal Instability Signature in Anaplastic Thyroid Carcinoma (2023)

Supplementary Table 5 from A Cell Proliferation and Chromosomal Instability Signature in Anaplastic Thyroid Carcinoma
Impuestos a la riqueza (2020)

A partir de entrevistas, observaciones y analisis de documentos oficiales, este articulo examina la contribucion que han tenido los partidos alemanes en el desarrollo de la politica publica fiscal. El analisis de las propuestas para un nuevo impuesto sobre el patrimonio por parte de algunos partidos de izquierda entre 2010 y 2017 permite entender por que estas organizaciones se asemejan a espacios de intermediacion entre los cargos electos y los actores extrapartidarios. El analisis se centra tanto en las propiedades de los cargos electos que intervienen en estos procesos de intermediacion como en los efectos de las estructuras de los partidos, que se caracterizan por la institucionalizacion de los intereses sociales dentro de organizaciones intrapartidarias. Constatamos que los partidos alemanes son capaces de presentarse como foros politicos donde se desarrollan tanto dispositivos fiscales como posiciones sobre las politicas publicas de sus oponentes.
Transformation of diaminocarane on a triosmium cluster. Absolute configuration of a cluster with a bridging imidyl ligand (1999)

The C–H activation of an NMe2 group in diaminocarane coordinated to an Os3 cluster results in the formation of (R,S)-{Os3(CO)10(μ-H){μ,η2(N,C)-(4R,6R,8S,10S)-1,7,7,10-tetramethyl-1,3-diazatricyclo[3.5.0.0]dec-1-en-2-yl}} diastereomers.
Differential optical imaging in animal models using infrared transillumination (2007)

We demonstrate the use of diffuse optical imaging via transillumination to detect cancerous tissue in a rat animal model. In this imaging modality infrared radiation is transmitted through whole animal tissue. The radiation is nonionizing and uses endogenous contrast: namely deoxyhemoglobin (Hb) and oxyhemoglobin (HbO). Differential image analysis is performed to visualize the presence of cancerous tissue. Varying levels of inspired air and carbogen gases ensure a differential response in absorption by blood due to changing levels of Hb and HbO. We believe that this response may be sufficient to provide contrast in differential image analysis. The present method also sheds light on physiological challenges in whole animal imaging especially with respect to significant optical signals from healthy tissue. Specifically, we have seen strong signals from abdominal regions in normal rats indicative of diet related anomalous transmission. We have also been able to track the changes in optical signal during animal death.
GH excess in bGH transgenic mice adversely affects bone density, architecture and quality (2013)

Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Modified Non-Inverting Buck-Boost PFC Converter with One Cycle Current Control Strategy (2019)

There are numerous electronic loads connected to ac grid which requires dc supply for which rectifiers are used. Now this depreciates the power factor at the ac side. In order to improve power factor boost type or buck-boost type PFC (Power Factor Correction) converters are used. This paper proposes a new buck-boost type PFC based converter with one cycle current controller (OCCC). OCCC with voltage loop is a novel controller for controlling the line current and make it follow the input voltage improving the power factor of the system. The main feature is the topology of buck-boost type PFC which is similar to non-inverting buck-boost converter with modified bridge rectifier and the control strategy ensures low THD (Total Harmonic Distortion) of input line current.
Utilization of critical TRIGA/LOPRA coupled core facilities (1976)

The utilization of the Illinois Advanced TRIGA reactor as a driving source for the loosely coupled Low Power Reactor (LOPRA) critical assembly in the TRIGA bulk shielding tank is described. Side reflectors of graphite were installed on LOPRA to reduce fuel inventory for criticality. Square wave operation of TRIGA produced increase in LOPRA power to several kilowatts in a four minute square wave. Local neutron flux and fuel temperature data in LOPRA were obtained throughout the studies. Techniques for evaluating average and local temperature feedback from the digitized time series data are presented. (author)
Roll maneuvers are essential for active reorientation of Caenorhabditis elegans in 3D media (2018)

Locomotion of the nematode <i>Caenorhabditis elegans</i> is a key observable used in investigations ranging from behavior to neuroscience to aging. However, while the natural environment of this model organism is 3D, quantitative investigations of its locomotion have been mostly limited to 2D motion. Here, we present a quantitative analysis of how the nematode reorients itself in 3D media. We identify a unique behavioral state of <i>C. elegans</i>-a roll maneuver-which is an essential component of 3D locomotion in burrowing and swimming. The rolls, associated with nonzero torsion of the nematode body, result in rotation of the plane of dorsoventral body undulations about the symmetry axis of the trajectory. When combined with planar turns in a new undulation plane, the rolls allow the nematode to reorient its body in any direction, thus enabling complete exploration of 3D space. The rolls observed in swimming are much faster than the ones in burrowing; we show that this difference stems from a purely hydrodynamic enhancement mechanism and not from a gait change or an increase in the body torsion. This result demonstrates that hydrodynamic viscous forces can enhance 3D reorientation in undulatory locomotion, in contrast to known hydrodynamic hindrance of both forward motion and planar turns.