gebhart/patrepeval huggingface dataset:
The Human Heart: A Self‐Renewing Organ (2008)

The dogma that the heart is a static organ which contains an irreplaceable population of cardiomyocytes prevailed in the cardiovascular field for the last several decades. However, the recent identification of progenitor cells that give rise to differentiated myocytes has prompted a re-interpretation of cardiac biology. The heart cannot be viewed any longer as a postmitotic organ characterized by a predetermined number of myocytes that is defined at birth and is preserved throughout life. The myocardium constitutes a dynamic entity in which new young parenchymal cells are formed to substitute old damaged dying myocytes. The regenerative ability of the heart was initially documented with a classic morphometric approach and more recently with the demonstration that DNA synthesis, mitosis, and cytokinesis take place in the newly formed myocytes of the normal and pathologic heart. Importantly, replicating myocytes correspond to the differentiated progeny of cardiac stem cells. These findings point to the possibility of novel therapeutic strategies for the diseased heart.
Le découpage laser des aciers à blindage (1988)

The investigation was carried out using a Cilas 2000 W CO 2 laser on various armor steel grades with thicknesses less than or equal to 15 mm.The purpose of this investigation was to thoroughly characterize the cuts so obtained, assess the influence of cutting parameters on the quality of cut edges and determine the contribution of laser cutting of physical and mechanical properties, fabricability and service behaviour of armor steels as compared to other means of cutting or machining.Special emphasis was laid on the attempt to know about residual stresses in the cut heat affected zone and to determine the fatigue resistance of the laser-cut or -machined parts.
Experimental Verification of a Back-to-Back 2L-3L Grid Connection System for a Marine Current Energy Converter (2016)

Rivers, tides and other ocean currents are renewable energy sources with great potential across the globe.A research group at Uppsala University is working on converting the power in rivers and oce ...
ChemInform Abstract: CYCLOADDITIONS. 26. REGIO‐ AND STEREOCHEMISTRY OF THE CYCLOADDITIONS OF DICHLOROKETENE TO 2‐METHYL‐ AND 3‐METHYL‐2‐CHOLESTENE (1979)

Abstract 2‐Methyl‐2‐cholesten (I) liefert mit dem aus Trichloracetylchlorid mit Zn/Cu/POC13 gebildeten Dichlorketen das Addukt (IIIa), das zu (IIIb) reduziert und mit Wasserstoffperoxid zum Lacton (IV) oxidiert werden kann.
A free-radical cyclization of .alpha.-bromo acetals leading to tetracyclic 9.beta.-picrasanes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA free-radical cyclization of .alpha.-bromo acetals leading to tetracyclic 9.beta.-picrasanesMoonsun Kim, Raymond S. Gross, Hubert Sevestre, Norma K. Dunlap, and David S. WattCite this: J. Org. Chem. 1988, 53, 1, 93–98Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/jo00236a019https://doi.org/10.1021/jo00236a019research-articleACS PublicationsRequest reuse permissionsArticle Views461Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of material strength levels and nugget sizes on fatigue behavior of resistance spot welded steel sheets (2019)

Tensile-shear test blanks were fabricated using high strength and low carbon steel sheets with three different strength levels by a resistance spot welding (RSW) procedure. The nugget sizes were changed by controlling the welding process parameters, resulting in the nugget sizes of 3√t, 4√t and 4.7√t, where t was the sheet thickness. Subsequently, tensile-shear static and fatigue tests were conducted to investigate the effects of strength levels of steels and nugget sizes on the mechanical properties of the welds. The tensile strength increased with increasing strength levels and nugget sizes. However, the fatigue strengths of the welds with the nugget sizes of 4√t and 4.7√t were nearly comparable irrespective of the strength levels of steels. That was because fatigue crack propagation life was dominant in the total fatigue life. In the welds with 3√t nugget size, the steel with higher strength level exhibited lower fatigue strength. It could be attributed to the lower bonding strength along the corona bond in the high strength steel.
The server is dead, long live the server: Rise of Serverless Computing,\n Overview of Current State and Future Trends in Research and Industry (2019)

Serverless computing -- an emerging cloud-native paradigm for the deployment\nof applications and services -- represents an evolution in cloud application\ndevelopment, programming models, abstractions, and platforms. It promises a\nreal pay-as-you-go billing (with millisecond granularity) with no waste of\nresources, and lowers the bar for developers by asking them to delegate all\ntheir operational complexity and scalability to the cloud provider. Delivering\non these promises comes at the expense of restricting functionality. In this\narticle we provide an overview of serverless computing, its evolution, general\narchitecture, key characteristics and uses cases that made it an attractive\noption for application development. Based on discussions with academics and\nindustry experts during a series of organized serverless computing workshops\n(WoSC), we also identify the technical challenges and open problems.\n
ChemInform Abstract: Efficient Synthesis of (+)‐Nojirimycin (Ia) and (+)‐1‐Deoxynojirimycin (Ib). (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Partial reverse concatenation for data storage (2014)

Coding schemes in data-storage systems use either conventional or reverse concatenation of a modulation code and an error-correction code. A new reverse concatenation scheme, called partial reverse concatenation, is introduced to reduce the coding overhead, improve the error-rate performance and simplify implementation. The proposed concatenation scheme uses an outer error-correction code, a high-rate modulation code and an inner error-correction code. The error-rate performance of partial reverse and conventional concatenation architectures are compared using measurements from tape drive channels. It is shown that, compared with a conventional concatenation scheme, an LDPC-code-based partial reverse concatenation scheme improves the signal-to-noise ratio that is required to achieve a bit-error rate of 1×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-20</sup> by 1.8 dB.
Mitigation of optical crosstalk penalty in photonic cross-connects using forward error correction (2003)

The use of forward error correction in all-optical networks for reducing the impact of dynamic crosstalk in photonic cross-connects based on three-dimensional microelectromechanical systems (3D-MEMS) is described. Error-free operation is achieved for coherent crosstalk levels up to −16 dB, which corresponds to a 13.5 dB coherent input signal dynamic range, using a RS(255/239) Reed-Solomon error correcting code with a coding gain of 6 dB in a 288×288 non-blocking 3D-MEMS switch.
Effect of four different pretreatments in nitrogen and phosphorus flow and mass balance in effluents of a recirculating aquaculture system. (2016)

The effluents from intensive aquaculture operations such as recirculating aquaculture systems (RAS) have high concentrations of sludge that can become a source of pollution if they are not properly treated and disposed. Anaerobic digestion is commonly used for biological degradation of sludge. Pretreatments prior to anaerobic digestion can enhance sludge degradation and decrease nitrogen and phosphorus load through microbial activity. This study examines the effect of four different pretreatments (biological, chemical, mechanical and thermal) in the N and P fluxes and mass balance from a RAS effluent in a seven-month period at ambient temperature. Each month a 15-day experiment was performed. All pretreatments, except chemical, removed N (thermal 29.78%, biological 36.75%, control 42.25%, mechanical 49.46%, chemical -7.68%). All pretreatments produced phosphorus (chemical 1.96%, mechanical 16.07%, thermal 24.37%, biological 32.39%, control 58.50%). Our results showed that the mechanical pretreatment was the most effective in removing N. In contrast, none of the pretreatments reduced P content in the sludge.
Toward ultralow-power computing at exteme with silicon carbide (SiC) nanoelectromechanical logic (2014)

Growing number of important application areas, including automotive and industrial applications as well as space, avionics, combustion engine, intelligent propulsion systems, and geo-thermal exploration require electronics that can work reliable at extreme conditions -- in particular at a temperature > 250°C and at high radiation (1-30 Mrad), where conventional electronics fail to work reliably. Traditionally, existing wideband-gap semiconductors, e.g., silicon carbide (SiC) transistor-based electronics have been considered most viable for high temperature and high radiation applications. However, the large-size, high threshold voltage, low switching speed and high leakage current make logic design with these devices unattractive. Additionally, the leakage current markedly increases at high temperature (in the range of 10 μA for a 2-input NAND gate), which induces self-heating effect and makes power delivery at high temperature very challenging. To address these issues, in this paper we present a computing platform for low-power reliable operation at extreme environment using SiC electromechanical switches. We show that a device-circuit-architecture co-design approach can provide reliable long-term operation with virtually zero leakage power.
Structural characterization of a non-heme iron active site in zeolites that hydroxylates methane (2018)

Iron-containing zeolites exhibit unprecedented reactivity in the low-temperature hydroxylation of methane to form methanol. Reactivity occurs at a mononuclear ferrous active site, α-Fe(II), that is activated by N<sub>2</sub>O to form the reactive intermediate α-O. This has been defined as an Fe(IV)=O species. Using nuclear resonance vibrational spectroscopy coupled to X-ray absorption spectroscopy, we probe the bonding interaction between the iron center, its zeolite lattice-derived ligands, and the reactive oxygen. α-O is found to contain an unusually strong Fe(IV)=O bond resulting from a constrained coordination geometry enforced by the zeolite lattice. Density functional theory calculations clarify how the experimentally determined geometric structure of the active site leads to an electronic structure that is highly activated to perform H-atom abstraction.
Characterization of high performance integrated optically addressed spatial light modulators (1998)

An improved design for optically addressed multiple-quantum-well spatial light modulators is reported. These integrated AlGaAs modulators are of high optical quality and are simple to fabricate. They exhibit excellent performance characteristics such as 10:1 reflection contrast ratio, 1.5% diffraction efficiency, 7-μm spatial resolution, and illumination sensitivity less than 1 μJ/cm2. Additionally, a new mode of operation is reported that dramatically improves the optical response of these devices at low frequencies. A new physical model is proposed that accurately describes the modulation process.
Computer programs for estimating substrate flux into steady‐state biofilms from pseudoanalytical solutions (2002)

Abstract Fixed‐film processes employing microorganisms attached to an inert surface (biofilms) are widely used for biological treatment of municipal and industrial wastewater. For optimal design and analysis of these processes, mathematical models are necessary that describe the dynamics of contaminant transport within these biofilms and the associated contaminant utilization by the microorganisms. However, these governing equations that typically involve Fickian diffusion for contaminant transport and Monod kinetics for contaminant utilization are inherently nonlinear and have no closed form solutions except under special conditions. This can restrict their use in the classroom as cumbersome numerical techniques must be used for their solution. This problem is well documented in the literature and several authors have presented pseudoanalytical solutions that replace numerical solutions with algebraic equations. In the present study, we present pseudoanalytical solution‐based computer programs for estimating substrate flux and biofilm thickness for a steady‐state biofilm. Depending upon the intended end use, these programs can either partially or totally automate the solution process. In the partial automation mode, they can serve to enhance student understanding of important concepts related to steady‐state biofilms, while complete automation can help bring more challenging and realistic problems associated with steady‐state biofilms into the classroom. The programs have been tested on MATLAB version 5.0 and are available as freeware for educational purposes. © 2002 Wiley Periodicals, Inc. Comput Appl Eng Educ 10: 26–32, 2002; Published online in Wiley InterScience ( www.interscience.wiley.com .); DOI 10.1002/cae.10017
Protein-Phospholipid Interactions in Nonclassical Protein Secretion: Problem and Methods of Study (2013)

Extracellular proteins devoid of signal peptides use nonclassical secretion mechanisms for their export. These mechanisms are independent of the endoplasmic reticulum and Golgi. Some nonclassically released proteins, particularly fibroblast growth factors (FGF) 1 and 2, are exported as a result of their direct translocation through the cell membrane. This process requires specific interactions of released proteins with membrane phospholipids. In this review written by a cell biologist, a structural biologist and two membrane engineers, we discuss the following subjects: (i) Phenomenon of nonclassical protein release and its biological significance; (ii) Composition of the FGF1 multiprotein release complex (MRC); (iii) The relationship between FGF1 export and acidic phospholipid externalization; (iv) Interactions of FGF1 MRC components with acidic phospholipids; (v) Methods to study the transmembrane translocation of proteins; (vi) Membrane models to study nonclassical protein release.
Supplemental Figure 5 from First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer (2023)

&lt;p&gt;PET detects PU-H71 retention by lymphoma. 62-year-old female with non-Hodgkin lymphoma. 124I-PU-H71 fusion PET/CT (left), CT (middle), and F-18 FDG fusion PET/CT (right) images show corresponding axial planes of chest. 124I-PU-H71 PET/CT obtained 24 hours post-injection. Mediastinal lymphomatous adenopathy (arrowhead) demonstrates PU-H71 avidity and FDG avidity.&lt;/p&gt;
Crown-Ether Derived Graphene Hybrid Composite for Membrane-Free Potentiometric Sensing of Alkali Metal Ions (2015)

We report the design and synthesis of newly functionalized graphene hybrid material that can be used for selective membrane-free potentiometric detection of alkali metal ions, represented by potassium ions. Reduced graphene oxide (RGO) functionalized covalently by 18-crown[6] ether with a dense surface coverage is achieved by the introduction of a flexible linking molecule. The resulting hybrid composite is highly stable and is capable of detecting potassium ions down to micromolar ranges with a selectivity over other cations (including Ca2+, Li+, Na+, NH4+) at concentrations up to 25 mM. This material can be combined further with disposable chips, demonstrating its promise as an effective ion-selective sensing component for practical applications.
Fenômeno e objeto na Fenomenologia de Merleau-Ponty (2016)

Procuro analisar o destino do conceito de objeto intencional ao ser transplantado do idealismo transcendental para o contexto do Lebenswelt como interpretado por Merleau-Ponty na Fenomenologia da percepção. Para isso, afasto tanto uma interpretação segundo a qual o idealismo husserliano cederia lugar ao realismo empírico quanto aquela para a qual Merleau-Ponty confundiria objeto qua intencional e objeto puro e simples. Busco mostrar que, na medida em que o Lebenswelt tem sua legalidade nas sínteses passivas do tempo, o objeto será concebido como Zeitobjekt cuja “indeterminação positiva” o situa tão distante do X vazio do idealismo quanto da coisa para além do fenômeno do realismo.
Deep sequencing of Danish Holstein dairy cattle for variant detection and insight into potential loss-of-function variants in protein coding genes (2015)

Deep sequencing of Danish Holstein genomes enabled us to identify 12.1 million variants. An investigation into LoF variants discovered a set of variants predicted to disrupt protein-coding genes. This catalog of variants will be a resource for future studies to understand variation underlying important phenotypes, particularly recessively inherited lethal phenotypes.
Ionization and mass analysis of nonvolatile compounds by particle bombardment-quadrupole-Fourier transform mass spectrometry (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIonization and mass analysis of nonvolatile compounds by particle bombardment-quadrupole-Fourier transform mass spectrometryDonald F. Hunt, Jeffrey. Shabanowitz, Robert T. McIver, Richard L. Hunter, and John E. P. SykaCite this: Anal. Chem. 1985, 57, 3, 765–768Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/ac00280a043https://doi.org/10.1021/ac00280a043research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DNA vaccines 2014 meeting: Highlights and overview (2015)

As in prior DNA vaccine meetings prominent researchers in the field nucleic acid vaccines from throughout the world met in San Diego from July 21-23 at the Westin Gaslamp Quarter Hotel in the beaut...
New paradigms in optical communications and networks (2013)

Software defined networking (SDN) is a broad term used to describe dynamic control of discrete computing, storage, switching, routing and/or transport devices to create an optimized network configuration for a given application or amount of traffic. SDN allows the network to automatically react to ever changing demands using a shared pool of resources, rather than relying on static designs to improve scalability and resiliency, while reducing cost. This separation of the control plane from the data plane provides the means to orchestrate a wide variety of network resources across multiple layers and multiple domains to achieve optimal utilization. This Feature Topic focuses on how SDN is being applied to the optical transport layer both within and between data centers, thus extending the work that until now has only been discussed at the upper network layers. Some of its enabling key technologies are also discussed.
Abstract 18068: mRNA Degradation of Mitochondrial Electron Transport Chain Proteins by Trsitetraprolin Protects the Heart Against Iron Deficiency (2017)

Introduction: Iron deficiency is the most common nutrient deficiency in the world, and cells respond to iron deficiency by activating iron regulatory proteins (IRP) to increase cellular iron uptake...
Dynamical Phase Transitions in Hierarchical Structures (1985)

We study diffusion in the presence of a hierarchical set of barriers. We find a phase transition in the dynamics from ordinary to anomalous diffusion as a parameter controlling the relative barrier heights is varied. Similar behavior is found in suitably defined random systems. Possible connections to glassy dynamics are discussed.
Comparative virulence studies and transcriptome analysis of Staphylococcus aureus strains isolated from animals (2016)

Several studies have been conducted to check the prevalence of methicillin-resistant strains of Staphylococcus aureus (MRSA) in animals and animal-derived food products but limited data are available regarding their virulence and associated gene expression profile. In the present study, antibiotic resistance and virulence of MRSA and methicillin-sensitive S. aureus animal isolates were determined in vitro by agar dilution, biofilm formation, adhesion, invasion and intracellular survivability assays. In addition, the pathogenicity of these isolates was examined in a murine model of S. aureus sepsis. MRSA1679a, a strain isolated from chicken, was observed to be highly virulent, in cell culture and in mouse model, and exhibited extensive resistant profile. Comparative gene expression profile of MRSA1679a and the reference human MRSA strain (ATCC 29213) was performed using Illumina-based transcriptome and RT-qPCR analyses. Several virulence elements including 22 toxin genes were detected in MRSA animal-isolate. In addition, we observed enhanced expression of crucial virulence regulators, such as sarA and KdpDE in MRSA animal-isolate compared to the human isolate. Collectively, gene expression profile including several virulence and drug-resistance factors confirmed the unique and highly virulent determinants of the MRSA strain of poultry origin which warrants further attention due to significant threat to public health.