gebhart/patrepeval huggingface dataset:
Targeting eIF4F translation initiation complex with SBI-756 sensitises B lymphoma cells to venetoclax (2020)

Our data highlight a novel combination for treatment of aggressive lymphomas, and establishes its efficacy and selectivity using preclinical models.
Two signals are required for accessory cells to induce B cell unresponsiveness. Tolerogenic Ig and prostaglandin. (1988)

We previously demonstrated that a lymphoid dendritic cell-like tumor line (P388AD.2) presented a normally tolerogenic signal, fluoresceinated sheep gamma-globulin (FL-SGG), as an immunogenic one. In contrast, macrophages derived from the peritoneal cavity potentiated the ability of FL-SGG to induce B cell unresponsiveness. In this paper we examined whether two different Ia+ splenic accessory cells differentially presented tolerogen to spleen cells or fluorescein (FL)-binding B cells. Interestingly, lymphoid dendritic cells presented FL-SGG to spleen cells and elicited augmented anti-FL antibody responses, whereas splenic macrophages presented this same moiety and elicited hapten-specific B cell unresponsiveness. The mechanism of splenic macrophage-elicited B cell negative signaling was investigated, and it was found that B cell unresponsiveness was abrogated in the presence of the cyclooxygenase inhibitor indomethacin. This observation suggested a crucial role for PG in B cell negative signaling. The addition of 10 nM PGE2 restored unresponsiveness in cultures treated with indomethacin and tolerogen-pulsed macrophages, even though this dose of PG had no effect on the ability of B cells to be triggered by an immunogenic signal. A role for T cells was excluded, inasmuch as purified hapten-specific B cells were specifically tolerized by FL-SGG-pulsed macrophages. Lymphoid dendritic cells pulsed with FL-SGG did not deliver a tolerogenic or immunogenic signal to FL-specific B cells. However, when PGE2 was supplied, B cell unresponsiveness was induced. Finally, we tested whether "non-tolerogenic" doses of FL-SGG could render hapten-specific B cells unresponsive in the presence of PGE2, but in the absence of accessory cells. Interestingly, the combination of non-tolerogenic amounts (10 to 1000 pg/ml) of FL-SGG in conjunction with PGE2 induced unresponsiveness, whereas neither moiety alone was effective. These results suggest that splenic macrophages and lymphoid dendritic cells exert opposing effects on the immune system as evidenced by the induction of negative or positive B cell signaling. Our observations suggest that one of the key factors in controlling whether an accessory cell delivers a tolerogenic signal is the ability to secrete PG.
Preparation of biologically active radioiodinated cholecystokinin for radioreceptor assay and radioimmunoassay. (1979)

A modified method is described for the preparation of stable, high specific activity radioiodinated cholecystokinin (CCK) by its conjugation to 125I-Bolton Hunter reagent (125I-BH). Purified radioiodinated CCK (125I-BH-CCK) stimulated amylase release from isolate rat pancreatic acini with a potency identical to that of native CCK. Further, 125I-BH-CCK was highly immunoreactive and reacted with antisera directed toward both the NH2- and COOH-terminal portions of the CCK molecule. Finally, 125I-BH-CCK bound to specific receptor sites on isolated pancreatic acini.
Myocardial Fas and Cytokine Expression in End‐Stage Heart Failure: Impact of LVAD Support (2008)

Left ventricular assist device (LVAD) support may facilitate myocardial recovery. We evaluated the impact of LVAD support on Fas expression in a cohort with end-stage heart failure. Myocardial gene expression was assessed pre- and post-LVAD by RNase protection assay and compared to control donor hearts. The expression of Fas is markedly elevated at the time of LVAD support and is tightly correlated with TNF expression. While interleukin (IL)-6 was significantly reduced by LVAD support, the impact of support on Fas was highly variable and tightly linked to tumor necrosis factor (TNF). The role of Fas in predicting recovery after LVAD support requires further investigation.
Polarization insensitive measurement of the fiber-optic nonlinear refractive index (2005)

This communication presents a novel cross-phase modulation method that allows one to measure the Kerr nonlinear index of common optical fibers with a high insensitivity to the polarization perturbations. The scheme is based on the use of an ortho-conjugated mirror (OCM).
Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis (2015)

The glucokinase-glucokinase regulatory protein (GK-GKRP) complex plays an important role in controlling glucose homeostasis in the liver. We have recently disclosed a series of arylpiperazines as in vitro and in vivo disruptors of the GK-GKRP complex with efficacy in rodent models of type 2 diabetes mellitus (T2DM). Herein, we describe a new class of aryl sulfones as disruptors of the GK-GKRP complex, where the central piperazine scaffold has been replaced by an aromatic group. Conformational analysis and exploration of the structure-activity relationships of this new class of compounds led to the identification of potent GK-GKRP disruptors. Further optimization of this novel series delivered thiazole sulfone 93, which was able to disrupt the GK-GKRP interaction in vitro and in vivo and, by doing so, increases cytoplasmic levels of unbound GK.
Production of Polyphenols and Flavonoids and Anti-Oxidant Effects of Lactic Acid Bacteria of Fermented Deer Antler Extract (2021)

The deer antler has been used as a major drug in oriental medicine for a long time. Recently, the demand for easy-to-take health functional foods is increasing due to economic development and changes in diet. As part of research on the development of functional materials for antlers, lactic acid fermentation of antler extract was performed. It was intended to develop a functional material with enhanced total polyphenol and flavonoid content and enhanced antioxidant activity. Lactic acid bacteria fermentation was performed by adding 4 types of lactic acid bacteria starter products, B. longum, Lb. Plantarum, Lb. acidophilus and mixture of 8 types of lactic acid bacteria to the antler water extract substrate, respectively. During the fermentation of lactic acid bacteria, the number of proliferation, total polyphenol and total flavonoid content, DPPH radical scavenging and antioxidant activity were quantified and evaluated. As a result of adding these four types of lactic acid bacteria to the antler water extract substrate, the number of lactic acid bacteria measured was 2.04~5.00×107. Meanwhile, a protease (Baciullus amyloliquefaciens culture: Maxazyme NNP DS) was added to the antler extract to decompose the peptide bonds of the contained proteins. Then, these four types of lactic acid bacteria were added and the number of lactic acid bacteria increased to 2.84×107 ~ 2.21×108 as the result of culture. The total polyphenol contents were 4.82~6.26 μg/mL in the lactic acid bacteria fermentation extracts, and after the reaction of protease enzyme and lactic fermentation, increased to 14.27~20.58 μg/mL. The total flavonoid contents were 1.52~2.21 μg/ml in the lactic acid bacteria fermentation extracts, and after the protease reaction and fermentation, increased to 5.59 ~ 8.11 mg/mL. DPPH radical scavenging activities of lactic acid bacteria fermentation extracts was 17.03~22.75%, but after the protease reaction and fermentation, remarkably increased to 32.82~42.90%.
Implementation of Motion Without Movement on Real 3D Objects (2004)

Researchers have developed a technique such that when the colors of a static image are toggled on a screen, the illusion of continuous movement in a certain direction is produced. This phenomenon is known as motion without movement. In our research we aim to extend the applications of this technique and apply it to real three-dimensional objects. In order to achieve the projection of images onto three-dimensional shapes, we use projectors called shader lamps, which apply an algorithm to a two-dimensional image so that it appears undistorted when projected onto a three-dimensional object. The resulting effect is that a static object appears to be moving continuously in a desired direction. In addition to applying the motion without movement technique to entire objects, we also examine its use on parts of an image as small as a pixel. Using a technique called optical flow, we determine the exact movement oparts of an image by taking a second image similar to the original, where image shapes have moved and determine in which direction. Finally, we extend the motion without movement technique beyond its previous applications to use on color rather than solely grayscale images, thus producing even more realistic results.
Bump in the ether: a framework for securing sensitive user input (2006)

Haemate P provided effective and safe hemostasis in VWD subjects undergoing elective surgery. Selection of Haemate P loading dose on the basis of VWF PK proved feasible.
Good Response to Chemotherapy Spares Irradiation for Extrarenal Rhabdoid Tumor Conferring Better Activities of Daily Living (2014)

A 7-year-old girl with stage IIA extrarenal rhabdoid tumor near the left cubital fossa received preoperative chemotherapy and surgical resection with median nerve reconstruction followed by postoperative high-dose chemotherapy. As preoperative chemotherapy resulted in decreased tumor size, disappearance of fluorodeoxyglucose-uptake, and pathologic complete response with total tumor resection, irradiation was successfully spared to avoid injury to the reconstructed nerve and inhibition of normal bone development. Two years after diagnosis, recurrence has not been observed and median nerve palsy is improving. This case suggests that radiation therapy could be spared for clinically and pathologically chemotherapy-good-responders in case total surgical resection is achieved.
Functionalized Congeners of P2Y 1 Receptor Antagonists: 2-Alkynyl ( N )-Methanocarba 2′-Deoxyadenosine 3′,5′-Bisphosphate Analogues and Conjugation to a Polyamidoamine (PAMAM) Dendrimer Carrier (2020)

The P2Y1 receptor is a prothrombotic G protein-coupled receptor (GPCR) activated by ADP. Preference for the North (N) ring conformation of the ribose moiety of adenine nucleotide 3′,5′-bisphosphate antagonists of the P2Y1 receptor was established by using a ring-constrained methanocarba (a bicyclo[3.1.0]hexane) ring as a ribose substitute. A series of covalently linkable N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphates containing extended 2-alkynyl chains was designed and binding affinity at the human (h) P2Y1 receptor determined. The chain of these functionalized congeners contained hydrophilic moieties, a reactive substituent, or biotin, linked via an amide. Variation of the chain length and position of an intermediate amide group revealed high affinity of carboxylic congener 8 (Ki 23 nM) and extended amine congener 15 (Ki 132 nM), both having a 2-(1-pentynoyl) group. A biotin conjugate 18 containing an extended ε-aminocaproyl spacer chain exhibited higher affinity than a shorter biotinylated analogue. Alternatively, click coupling of terminal alkynes of homologous 2-dialkynyl nucleotide derivatives to alkyl azido groups produced triazole derivatives that bound to the P2Y1 receptor following deprotection of the bisphosphate groups. The preservation of receptor affinity of the functionalized congeners was consistent with new P2Y1 receptor modeling and ligand docking. Attempted P2Y1 antagonist conjugation to PAMAM dendrimer carriers by amide formation or palladium-catalyzed reaction between an alkyne on the dendrimer and a 2-iodopurine-derivatized nucleotide was unsuccessful. A dialkynyl intermediate containing the chain length favored in receptor binding was conjugated to an azide-derivatized dendrimer, and the conjugate inhibited ADP-promoted human platelet aggregation. This is the first example of attaching a strategically functionalized P2Y receptor antagonist to a PAMAM dendrimer to produce a multivalent conjugate exhibiting a desired biological effect, i.e. antithrombotic action.
Neural Correlates of Antinociception in Borderline Personality Disorder (2006)

The interaction between increased pain-induced response in the dorsolateral prefrontal cortex and deactivation in the anterior cingulate and the amygdala is associated with an antinociceptive mechanism in patients with BPD.
Arteriolar narrowing as predictor of hypertension: Authors' reply (2004)

EDITOR—Firstly, we agree that pre-existing blood pressure is an important predictor of overt hypertension. As in the Framingham study,1 our participants whose baseline blood pressure was classified as “prehypertensive” were more likely to develop clinical hypertension than those classified as “normal” (figure 2 in our paper). This effect was …
Instabilities in parallel channel of forced-convection boiling upflow system, (IV). Instabilities in multi-channel system and with boiling in downcomer. (1981)

The steam generator for LMFBR is composed of multiple tubes with the different flow conditions from each other. Most of the computer codes developed to evaluate the stability analyze a representative tube on the basis of the assumption of the constant pressure drop between the feedwater header and the steam one as single channel. Although the method selecting the representative channel has never been investigated, it is one of the purposes of this paper to examine the approximate method to evaluate the stable boundary exactly. It is another purpose of this paper to research the mechanism of the limit cycle oscillation observed in 1 MW SG without the thermal insulated downcomer of Power Reactor and Nuclear Fuel Development Corp., so that the effect of boiling in downcomer on the flow instability is studied experimentally. The slug excursion instability, which does not belong to Bouré's classification of two-phase flow instability, is observed in our experimental apparatus. Then, this mechanism is studied under the various conditions of heat fluxes of downcomer and riser, liquid temperature and inlet velocity
A CPLD-based RC4 cracking system (2003)

Presents a complex programmable logic device (CPLD) based system for cracking the RC4 (Rivest Cipher 4) encryption algorithm. The system achieves an outstanding price/performance ratio, easily beating other low-cost approaches, such as commodity PCs. The system was implemented using a single Altera EPF10K20 CPLD on an Altera UP1 Education Board. This CPLD is large enough to contain the control unit and five functional units. Measured performance on our prototype shows that we can crack a 32-bit RC4 in an expected time of 15 hours (30 hours worst case). This gives a theoretical expected time of 159 days to crack 40-bit keys-the maximum possible key length that can exported from Canada and the USA. Our results demonstrate the effectiveness of programmable logic (CPLD or FPGA) against even a cryptosystem designed for software implementation.
Towards Adaptive MIMO Radar – Receiver Processing for Orthogonally Coded FMCW Waveforms (2019)

In this paper, a novel design and processing of nearly orthogonal waveforms based on frequency-modulated continuous-wave (FMCW) signals for multiple-input, multiple-output (MIMO) radars is presented. The design, implementation and results of the complete system, capable of detection and imaging of radar targets, are here described. The orthogonality of sounding signals is critical for multi-channel radar applications since the interference between signals can significantly limit the radar's ability for observation of weak targets in presence of stronger targets and background clutter. The orthogonal waveforms are designed by coding consecutive complex FMCW signals in a frame so that they can be sent to the different transmit antennas of the radar allowing the simultaneous operation of all transmit channels. Moreover, a radar receiver processing, based on a complex frame based convolution between transmit and received waveforms together with 4-dimensional Fast Fourier Transform (4D-FFT) beamforming, is presented.
Conformational characteristics of rigid cyclic nucleotides. 3. The solution conformation of .beta.-lyxonucleoside cyclic 2',5'- and 3',5'-monophosphates and of .alpha.-arabinonucleoside cyclic 2',5'-monophosphates. Implications for evaluation of the solution properties of nucleoside analogs (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformational characteristics of rigid cyclic nucleotides. 3. The solution conformation of .beta.-lyxonucleoside cyclic 2',5'- and 3',5'-monophosphates and of .alpha.-arabinonucleoside cyclic 2',5'-monophosphates. Implications for evaluation of the solution properties of nucleoside analogsMalcolm MacCoss, Clinton F. Ainsworth, Gregory Leo, Fouad S. Ezra, and Steven S. DanylukCite this: J. Am. Chem. Soc. 1980, 102, 24, 7353–7361Publication Date (Print):November 19, 1980Publication History Published online1 May 2002Published inissue 19 November 1980https://pubs.acs.org/doi/10.1021/ja00544a034https://doi.org/10.1021/ja00544a034research-articleACS PublicationsRequest reuse permissionsArticle Views96Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Magneto-transport and microstructure of Co2Fe(Ga0.5Ge0.5)/Cu lateral spin valves prepared by top-down microfabrication process (2014)

Heusler alloy-based lateral spin valves with ohmic contacts are prepared for the Co2Fe(Ga0.5Ge0.5)/Cu system by means of the top-down microfabrication process. The magneto-transport and microstructure are characterized to investigate the influence of the microfabrication route on the spin dependent transport of lateral spin valves systematically. A large non-local spin signal (△RS) of 17.3 mΩ is observed at room temperature, which is attributed to the highly spin-polarized Co2Fe(Ga0.5Ge0.5) ferromagnet and the clean Co2Fe(Ga0.5Ge0.5)/Cu interfaces confirmed by transmission electron microscopy. Based on the general expression of one-dimensional spin diffusion model, we discuss the importance of interfacial spin polarization in Heusler alloy-based lateral spin valves.
Rates of Glucose Change Measured by Blood Glucose Meter and the GlucoWatch Biographer During Day, Night, and Around Mealtimes (2004)

Glucose values were almost equally unstable before and after meals. Glycemic instability around dinner was different in type 1 and type 2 diabetes. The GlucoWatch Biographer was found to be effective in tracking trends in glucose levels and yielded similar results as obtained by finger-prick blood samples.
Learning Doppler with Deep Neural Networks and its Application to Intra-Cardiac Echography (2018)

Cardiac ablation therapy is an effective treatment for atrial fibrillation and ventricular tachycardia that relies on the creation of electrically isolating scars, e.g. through heat. The ability to reliably visualize and assess the formation of these lesions during the procedure would greatly enhance the therapy's success rate and safety. Tissue Doppler echography enables measurement of tissue strain, and could therefore be used to monitor and quantify the stiffening of developing lesions. In tissue Doppler, the tradeoff between spatiotemporal resolution and estimation accuracy/precision is balanced by manually tweaking the fast-and slow-time range gates, with the optimal settings varying across measurements and desired clinical objectives. Convolutional neural networks have shown remarkable performance at learning to execute a large variety of signal and image processing tasks. In this work, we show how a deep neural network can be trained to robustly fulfil Doppler imaging functionality, which we term DopplerNet.
Conception et déploiement d’un réseau d’IoT en technologie LoRa permettant de connecter l’ENSEIRB-MATMECA (2017)

National audience
Slider Vibration Analysis at Contact Using Time-Frequency Analysis and Wavelet Transforms (2000)

Time-frequency analysis and wavelet transforms are employed to investigate transient contact dynamics at the head/disk interface of computer hard drives. Wavelet transforms are used to resolve multiple short consecutive contacts at high time resolution at high frequencies. The reassignment method is applied to the time-frequency distribution to enhance the time-frequency resolution, thereby allowing to resolve air-bearing and slider body frequencies simultaneously. The results indicate that strong impacts between slider and disk can lead to excitations of slider body and suspension vibrations. Finite element modal analysis of nano and pico glide sliders is found to be in good agreement with experimentally measured frequencies.
Association between Urine Phthalate Levels and Poor Attentional Performance in Children with Attention-Deficit Hyperactivity Disorder with Evidence of Dopamine Gene-Phthalate Interaction (2014)

Although there is some evidence supporting the existence of an association between prenatal maternal or postnatal child's urine phthalate metabolite concentrations and poor attentional performances, the interaction between urine phthalate metabolite levels and genetic variation for neuropsychological deficit of attention-deficit hyperactivity disorder (ADHD) has not been examined. The aim of this study was to determine whether phthalate metabolites in urine are associated with poor neuropsychological performance in children with ADHD, and whether such association is affected by genotype-phthalate interaction. A cross-sectional examination of urine phthalate metabolite concentrations and the continuous performance test (CPT) were performed in 179 Korean children with ADHD recruited from department of psychiatry of university hospital. Correlations between urine phthalate metabolite concentrations and the CPT scores were investigated, and the interaction of phthalate metabolite levels with the selected polymorphisms at major candidate genes for ADHD, namely dopamine receptor D4 (DRD4), dopamine transporter, α-2A-adrenergic receptor, and norepinephrine transporter genes. For the subjects with the DRD4 4/4 genotype, there were significant associations of the urine phthalate metabolite concentrations with the number of omission errors, the number of commission errors, and the response time variability scores on the CPT. However, for the subjects without the DRD4 4/4 genotype, no significant associations were found. The results of this study suggest a possible association between phthalate metabolite concentrations and poor attentional performances of ADHD as well as a genetic influence on this association. Further prospective and epigenetic studies are needed to investigate causality and pathophysiological mechanisms.