gebhart/patrepeval huggingface dataset:
Snake venom antibodies in Ecuadorian Indians. (1981)

Serum samples from 223 Waorani Indians, a tribe in eastern Ecuador, were investigated by enzyme-linked immunosorbent assay for antibodies to snake venom. Seventy-eight per cent were positive, confirming the highest incidence and mortality from snake bite poisoning yet recorded in the world. Most samples were positive for more than one venom antibody. Antibodies were found to venoms of Bothrops viper in 60% of positive cases, of Micrurus coral snake in 21%, and of the bushmaster, Lachesis muta, in 18%. Further studies are needed to determine whether high venom-antibody levels afford protection against further snake envenoming.
Next Generation Propulsion System Architectures (2007)

This paper describes the creation of novel propulsi on system architectures using algebraic design techniques . The objective is to create novel arrangements comprised of one or more planetary gear sets, an internal combustion engine, a pair of motor-generators and several torque-trans mitting mechanisms (clutches and brakes). The algebraic des ign procedure represents the planetary gear sets, fixed interconnections, clutches/brakes, and motor-generator s ets as algebraic constraints. Appropriate subsets of const raint equations are solved to identify viable propulsion system designs. We have used the above design approach to create several novel candidate multi-speed transmissions a s well as electrically-variable transmission concepts.
Smartphone-Based Gaze Gesture Communication for People with Motor Disabilities (2017)

Current eye-tracking input systems for people with ALS or other motor impairments are expensive, not robust under sunlight, and require frequent re-calibration and substantial, relatively immobile setups. Eye-gaze transfer (e-tran) boards, a low-tech alternative, are challenging to master and offer slow communication rates. To mitigate the drawbacks of these two status quo approaches, we created GazeSpeak, an eye gesture communication system that runs on a smartphone, and is designed to be low-cost, robust, portable, and easy-to-learn, with a higher communication bandwidth than an e-tran board. GazeSpeak can interpret eye gestures in real time, decode these gestures into predicted utterances, and facilitate communication, with different user interfaces for speakers and interpreters. Our evaluations demonstrate that GazeSpeak is robust, has good user satisfaction, and provides a speed improvement with respect to an e-tran board; we also identify avenues for further improvement to low-cost, low-effort gaze-based communication technologies.
Molecular Docking of Cathepsin L Inhibitors in the Binding Site of Papain (2010)

ADVERTISEMENT RETURN TO ISSUEPREVErratumORIGINAL ARTICLEThis notice is a correctionMolecular Docking of Cathepsin L Inhibitors in the Binding Site of PapainMary Pat Beavers*, Michael C. Myers, Parag P. Shah, Jeremy E. Purvis, Scott L. Diamond, Barry S. Cooperman, Donna M. Huryn, and Amos B. Smith, IIICite this: J. Chem. Inf. Model. 2010, 50, 12, 2274Publication Date (Web):November 9, 2010Publication History Received25 March 2010Published online9 November 2010Published inissue 27 December 2010https://pubs.acs.org/doi/10.1021/ci100114ehttps://doi.org/10.1021/ci100114ecorrectionACS PublicationsCopyright © 2010 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views572Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (18 KB) Get e-Alertsclose Get e-Alerts
Super-Resolution-based Inpainting (2013)

Abstract. Thispaperintroducesanewexamplar-basedinpaintingframework. A coarse version of the input image is first inpainted by a nonparametric patch sampling. Compared to existing approaches, some improvements have been done (e.g. filling order computation, combination of K nearest neighbours). The inpainted of a coarse version of the input image allows to reduce the computational complexity, to be less sensitive to noise and to work with the dominant orientations of image structures. From the low-resolution inpainted image, a single-image super-resolution is applied to recover the details of missing areas. Experimental results on natural images and texture synthesis demonstrate the effectiveness of the proposed method. Key words: examplar-based inpainting, super-resolution 1
THE DEVELOPMENT OF THE IMMUNE RESPONSE (1963)

By intensive stimulation with large amounts of Salmonella flagellar antigen, newborn rabbits were induced to form high titer flagellar agglutinins usually by the 7th to 10th day of life. Characterization of the agglutinins at various times during the first 30 days of life revealed that the earliest antibody which appeared was a gamma-1 macroglobulin, and that 7S gamma-2 globulins did not appear until the 4th or 5th week of life. In contrast, the adult animals produced macroglobulin antibodies for only 3 to 5 days before the lower molecular weight variety appeared. The infant macroglobulin appears to be similar in all respects to adult macroglobulin antibodies. These data are interpreted to indicate that the newborn and adult rabbit differ in their response to this type of stimulus not in timing of macroglobulin antibody production, but chiefly in the prolonged interval, which precedes the development of the capacity for the 7S type response in the newborn animal.
Paired-pulse stimulation at glutamatergic synapses - pre- and postsynaptic components (2010)

Paired-pulse stimulation is a standard protocol that has been used for decades to characterize dynamic systems: the differences in responses to two sequential identical stimuli as a function of inter-stimulus interval provide quantitative information on the dynamics of the system. In neuroscience, the paired-pulse protocol is also widely used at multiple levels of analysis, from behavioral conditioning to synaptic plasticity, and in particular to define the biomolecular mechanism of learning and memory. In a system as small and complex as synapses, it is extremely challenging - if not impossible - to experimentally gain access to the multitude of possible readouts. In the present study, we first introduce a computational synaptic modeling platform that we developed and calibrated based on experimental data from both our laboratories and a variety of publications. We then show how this platform allows not only to replicate experimental data, but also to go beyond technological boundaries and investigate the main parameters responsible for regulation of synaptic transmission and plasticity. The results provide critical information regarding the respective role of various subsynaptic processes and of their interactions. Additionally, this approach can strengthen our understanding of potential dysfunctions (pathologies) and suggest potential approaches to re-establish normal function.
Recent Advances on the Magnetron with Diffraction Output (2020)

The relativistic magnetron with diffraction output (MDO) was predicted in particle-in-cell (PIC) simulations to achieve 70% electron beam-to-microwave power conversion efficiency. In experiments at the University of New Mexico (UNM) a conversion efficiency of >60% was measured in experiment until the cathode endcap flashed over, after which the efficiency dropped to below 40% [1]. Since these experiments the UNM group predicted similar efficiencies for an MDO powered using a virtual cathode [2]. The proposed advantage of operating the MDO with a virtual cathode as opposed to a physical cathode was the elimination of pulse shortening via AK gap closure. Finally, more recent work suggests that the use of a magnetic mirror to suppress axial leakage current can lead to maximal efficiency of an MDO driven by a virtual cathode [3]–[5]. This presentation will provide the latest experimental results on these subjects.
Souche vaccinale marquée du virus de la peste des petits ruminants et son procédé d’obtention (2014)

La présente invention concerne l'obtention d'une souche vaccinale marquée du virus de la peste des petits ruminants, par production d'un clone infectieux, et marquage de ce clone par substitution d'un épitope dudit virus par un épitope exogène.
Fast Elliptic Curve Multiplications Resistant against Side Channel Attacks (2005)

This paper proposes fast elliptic curve multiplication algorithms resistant against side channel attacks, based on the Montgomery-type scalar multiplication. The proposed scalar multiplications can be applied to all curves over prime fields, e.g., any standardized curves over finite fields with characteristic larger than 3. The method utilizes the addition formulas xECDBL and xECADD assembled by only x-coordinates of points, and is applicable for any types of curves over finite fields. Then, we encapsulate two addition formulas into one formula xECADDDBL, which accomplishes a faster computation because several auxiliary variables of two formulas can be shared. We also develop a novel addition chain for the new formula, with which we can compute scalar multiplications. The improvement of our scalar multiplications over previous Coron's dummy operation method is about 18% for a 160-bit scalar multiplication. Our method requires no table-up of precomputed points and it is suitable for the implementation on memory constraint computing architectures, e.g., smart cards. Moreover, we optimize the proposed algorithms for parallelized implementations with SIMD operations. Compared with the similar scheme proposed by Fischer et al., our scheme is about 16% faster.
Tissue distribution of isoniazid and its metabolites in rats. (1981)

Distribution of isoniazid and its metabolites was observed in the liver, kidney, lung and plasma after the subcutaneous administration of isoniazid to rats. The tissue levels of isoniazid, acetylisoniazid, acetylhydrazine, 1,2-diacetylhydrazine and hydrazine were determined by mass fragmentography using a gas chromatograph-mass spectrometer equipped with a multiple ion detector-peak matcher. Using the compounds labeled with a stable isotope as an internal standard, namely the isotope dilution method, made it possible to estimate trace amounts of these metabolites in the tissues. The amount of hydrazine was much less than the other hydrazines, but the metabolite which is well known as a mutagen, could be successfully detected in the tissues and plasma. The greater part of free hydrazine is formed through a direct hydrolysis of isoniazid. The isoniazid-hydrolyzing activity was found to be significantly higher in the liver homogenate. This suggested that hydrazine formation is mainly caused by hepatic hydrolysis.
Organometallic molecule-inorganic surface coordination and catalytic chemistry. Facile and selective alkane activation by supported tetraallylthorium (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganometallic molecule-inorganic surface coordination and catalytic chemistry. Facile and selective alkane activation by supported tetraallylthoriumMoris S. Eisen and T. J. MarksCite this: Organometallics 1992, 11, 12, 3939–3941Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/om00060a006https://doi.org/10.1021/om00060a006research-articleACS PublicationsRequest reuse permissionsArticle Views152Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Measurement range elongation based on a temporal gating scheme in Brillouin correlation domain distributed discrimination system for strain and temperature operated by a single laser (2011)

We have demonstrated distributed discrimination of strain and temperature by localizing and scanning both the Stimulated Brillouin scattering (SBS) and the Brillouin dynamic grating (BDG) along a polarization maintaining fiber, with elongated measurement range. The localization and scanning is performed by a correlation domain technique, whose measurement range is restricted by the distance between consecutive correlation peaks. To overcome this restriction, we applied a temporal gating scheme to the system, enlarging the measurement range from ~8 m to ~500 m. Here, we report the results confirming the effectiveness of this scheme in a system operated by a single laser source and demonstrate strain-temperature discrimination when strain or temperature is applied to segments on the 500-m-long fiber under test.
Magnetic Nanosensor for Detection and Profiling of Erythrocyte-Derived Microvesicles (2013)

During the course of their lifespan, erythrocytes actively shed phospholipid-bound microvesicles (MVs). In stored blood, the number of these erythrocyte-derived MVs has been observed to increase over time, suggesting their potential value as a quality metric for blood products. The lack of sensitive, standardized MV assays, however, poses a significant barrier to implementing MV analyses into clinical settings. Here, we report on a new nanotechnology platform capable of rapid and sensitive MV detection in packed red blood cell (pRBC) units. A filter-assisted microfluidic device was designed to enrich MVs directly from pRBC units, and label them with target-specific magnetic nanoparticles. Subsequent detection using a miniaturized nuclear magnetic resonance system enabled accurate MV quantification as well as the detection of key molecular markers (CD44, CD47, CD55). When the developed platform was applied, MVs in stored blood units could also be monitored longitudinally. Our results showed that MV counts increase over time and, thus, could serve as an effective metric of blood aging. Furthermore, our studies found that MVs have the capacity to generate oxidative stress and consume nitric oxide. By advancing our understanding of MV biology, we expect that the developed platform will lead to improved blood product quality and transfusion safety.
Enhanced light harvesting of nitride-based nanopillars covered with ZnO using indium–tin oxide nanowhiskers (2014)

Nitride-based nanopillars were successfully fabricated by nanoimprint lithography. A nanowhisker of indium–tin oxide (ITO) deposited by on oblique evaporation method was investigated in nitride-based nanopillars and thin ZnO layers grown by atomic layer deposition (ALD). From the results of field-emission scanning electron microscopy (SEM) measurement, it was found that ITO whiskers grew on nitride-based nanopillars covered with ZnO. Moreover, from the results of UV–visible spectrophotometry and bidirectional reflectance distribution function (BRDF) measurements, it was found that this hybrid structure of ITO nanowhiskers above a ZnO medium enhanced the broadband and angle-independent antireflection in the range between 380 and 600 nm. We used the hybrid design of the ITO/ZnO structure to achieve the lowest reflectance value between 3.8 and 10.9% in a quantum well absorption range.
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer (2008)

Pancreas ductal adenocarcinoma (PDAC) is a highly lethal cancer that typically presents as advanced, unresectable disease. This invasive tendency, coupled with intrinsic resistance to standard therapies and genome instability, are major contributors to poor long-term survival. The genetic elements governing the invasive propensity of PDAC have not been well elucidated. Here, in the course of validating resident genes in highly recurrent and focal amplifications in PDAC, we have identified Rio Kinase 3 (RIOK3) as an amplified gene that alters cytoskeletal architecture as well as promotes pancreatic ductal cell migration and invasion. We determined that RIOK3 promotes its invasive activities through activation of the small G protein, Rac. This genomic and functional link to Rac signaling prompted a genome wide survey of other components of the Rho family network, revealing p21 Activated Kinase 4 (PAK4) as another amplified gene in PDAC tumors and cell lines. Like RIOK3, PAK4 promotes pancreas ductal cell motility and invasion. Together, the genomic and functional profiles establish the Rho family GTP-binding proteins as integral to the hallmark invasive nature of this lethal disease.
Alternative “Bases” for Gradient-Based Optimization of Parameterized FM Radar Waveforms (2023)

Even for a fixed time-bandwidth product there are infinite possible spectrally-shaped random FM (RFM) waveforms one could generate due to their being phase-continuous. Moreover, certain RFM classes rely on an imposed basis-like structure scaled by underlying parameters that can be optimized (e.g. gradient-descent and greedy search have been demonstrated). Because these structures must include oversampling with respect to 3-dB bandwidth to account for sufficient spectral roll-off (necessary to be physically realizable in hardware), they are not true bases (i.e. not square). Therefore, any individual structure cannot represent all possible waveforms, with the waveforms generated by a given structure tending to possess similar attributes. Here we examine these attributes for some particular design structures, which may inform their selection for given radar applications.
Book Review: Methods of Enzymatic Analysis. Vol. 3: Enzymes 1. Oxidoreductases, Transferases. xxiv, 605 pp., bound, DM 224.00; Vol. 4: Enzymes 2. Esterases, Glycosidases, Lyases, Ligases. xxiv, 426 pp., bound, DM 198.00; Vol. 5: Enzymes 3. Peptidases, Proteinases and Their Inhibitors. xxvii, 558 pp., bound, DM 235.00 (prices when ordering all ten volumes). Edited by H. U. Bergmeyer, J. Bergmeyer, and M. Grassl (1985)

<em>Angewandte Chemie International Edition in English</em> is one of the prime chemistry journals in the world, publishing research articles, highlights, communications and reviews across all areas of chemistry.
Self-Driving Networks (2018)

This chapter presents a new vision of network operations, the self-driving network, that takes automation to the next level. This is not a description of existing work; rather, it is a challenge to dramatically rethink how we manage networks (or rather, how we do not manage networks). It draws upon an analogy with the development of self-driving cars and presents motivations for this effort. It then describes the technologies needed to implement this and an overall architecture of the system. As this endeavor will cause a major shift in network management, the chapter offers an evolutionary path to the end goal. Some of the consequences and human impacts of such a system are touched upon. The chapter concludes with some research topics and a final message. Key takeaways are that machine learning and feedback loops are fundamental to the solution; a key outcome is to build systems that are adaptive and predictive, for the benefit of users.
Synthese thioanaloger Δ8‐Tetrahydrocannabinole (1977)

Abstract Bei der Kondensation von p ‐Menthadienol 1 mit den Thiophloroglucinethern 2a–c erhält man neben den erwarteten thioanalogen Δ 8 ‐THC‐Derivaten 3a–c auch noch die „anomalen”︁ Δ 8 ‐Derivate 4a–c . Die Unterscheidung der Isomeren gelingt 1 H‐NMR‐spektroskopisch.
Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats (1998)

To investigate how hypercalcemia blunts renal concentrating ability, alterations in basal and arginine vasopressin (AVP)-elicited osmotic water (Pf) and urea (Purea) permeabilities were measured in isolated perfused terminal inner medullary collecting ducts (IMCD) from control and chronically hypercalcemic rats after dihydrotachysterol (DHT) (M. Levi, L. Peterson, and T. Berl. Kidney Int. 23: 489-497, 1983) treatment. The IMCD Pf of DHT-treated rats did not increase significantly after AVP and was accompanied by a significant 87 +/- 4% reduction in aquaporin-2 (AQP-2) protein but not mRNA. In contrast, both basal and AVP-elicited IMCD Purea from DHT rats were significantly increased and accompanied by a significant 41 +/- 11% increase in AVP-regulated urea transporter protein content. Immunoblotting with anti-calcium/polyvalent cation-sensing receptor protein (CaR) antiserum revealed specific alterations in CaR bands in endosomes purified from the apical membranes of inner medulla of DHT rats. These data are the first detailed analyses of hypercalcemia-induced alterations in AVP-regulated permeabilities and membrane transporters in IMCD. We conclude that selective alterations in IMCD transport occur in hypercalcemia, permitting the body to dispose of excess calcium without forming calcium-containing renal stones.
Toward End-to-End, Full-Stack 6G Terahertz Networks (2020)

Recent evolutions in semiconductors have brought the terahertz band into the spotlight as an enabler for terabit-per-second communications in 6G networks. Most of the research so far, however, has focused on understanding the physics of terahertz devices, circuitry, and propagation, and on studying physical layer solutions. However, integrating this technology in complex mobile networks requires proper design of the full communication stack, to address link- and system-level challenges related to network setup, management, coordination, energy efficiency, and end-to-end connectivity. This article provides an overview of the issues that need to be overcome to introduce the terahertz spectrum in mobile networks, from a MAC, network, and transport layer perspective, with consideration on the performance of end-to-end data flows on terahertz connections.
Defensive flocculent emissions in a tiger moth, Homoeocera stictosoma (Arctiidae: Arctiinae) (2004)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.