gebhart/patrepeval huggingface dataset:
Methanocarba Modification of Uracil and Adenine Nucleotides: High Potency of Northern Ring Conformation at P2Y 1 , P2Y 2 , P2Y 4 , and P2Y 11 but Not P2Y 6 Receptors (2020)

The potency of nucleotide antagonists at P2Y1 receptors was enhanced by replacing the ribose moiety with a constrained carbocyclic ring (Nandanan, et al. J. Med. Chem. 2000, 43, 829—842). We have now synthesized ring-constrained methanocarba analogues (in which a fused cyclopropane moiety constrains the pseudosugar ring) of adenine and uracil nucleotides, the endogenous activators of P2Y receptors. Methanocarba-adenosine 5′-triphosphate (ATP) was fixed in either a Northern (N) or a Southern (S) conformation, as defined in the pseudorotational cycle. (N)-Methanocarba-uridine was prepared from the 1-amino-pseudosugar ring by treatment with β-ethoxyacryloyl cyanate and cyclization to form the uracil ring. Phosphorylation was carried out at the 5′-hydroxyl group through a multistep process: Reaction with phosphoramidite followed by oxidation provided the 5′-monophosphates, which then were treated with 1,1′-carbonyldiimidazole for condensation with additional phosphate groups. The ability of the analogues to stimulate phospholipase C through activation of turkey P2Y1 or human P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11 receptors stably expressed in astrocytoma cells was measured. At recombinant human P2Y1 and P2Y2 receptors, (N)-methanocarba-ATP was 138- and 41-fold, respectively, more potent than racemic (S)-methanocarba-ATP as an agonist. (N)-methanocarba-ATP activated P2Y11 receptors with a potency similar to ATP. (N)-Methanocarba-uridine 5′-triphosphate (UTP) was equipotent to UTP as an agonist at human P2Y2 receptors and also activated P2Y4 receptors with an EC50 of 85 nM. (N)-Methanocarba-uridine 5′-diphosphate (UDP) was inactive at the hP2Y6 receptor. The vascular effects of (N)-methanocarba-UTP and (N)-methanocarba-UDP were studied in a model of the rat mesenteric artery. The triphosphate was more potent than UTP in inducing a dilatory P2Y4 response (pEC50 = 6.1 ± 0.2), while the diphosphate was inactive as either an agonist or antagonist in a P2Y6 receptor-mediated contractile response. Our results suggest that new nucleotide agonists may be designed on the basis of the (N) conformation that favors selectivity for P2Y1, P2Y2, P2Y4, and P2Y11 receptors.
Bromide‐Assisted Oxidation of Substituted Phenols with Hydrogen Peroxide to the Corresponding p‐Quinol and p‐Quinol Ethers over WO42−‐Exchanged Layered Double Hydroxides (2004)

A simple and efficient one-pot synthesis of p-quinols and their ethers occurs over tungstate-exchanged layered double hydroxides (WO42−-LDHs), which catalyze the bromide-assisted oxidation of substituted phenols to the corresponding 4-alkoxy- and 4-hydroxycyclohexa-2,5-dienones in high yields (see scheme).
Analog sensitive chemical inhibition of the DEAD‐box protein DDX3 (2015)

Proper maintenance of RNA structure and dynamics is essential to maintain cellular health. Multiple families of RNA chaperones exist in cells to modulate RNA structure, RNA-protein complexes, and RNA granules. The largest of these families is the DEAD-box proteins, named after their catalytic Asp-Glu-Ala-Asp motif. The human DEAD-box protein DDX3 is implicated in diverse biological processes including translation initiation and is mutated in numerous cancers. Like many DEAD-box proteins, DDX3 is essential to cellular health and exhibits dosage sensitivity, such that both decreases and increases in protein levels can be lethal. Therefore, chemical inhibition would be an ideal tool to probe the function of DDX3. However, most DEAD-box protein active sites are extremely similar, complicating the design of specific inhibitors. Here, we show that a chemical genetic approach best characterized in protein kinases, known as analog-sensitive chemical inhibition, is viable for DDX3 and possibly other DEAD-box proteins. We present an expanded active-site mutant that is tolerated in vitro and in vivo, and is sensitive to chemical inhibition by a novel bulky inhibitor. Our results highlight a course towards analog sensitive chemical inhibition of DDX3 and potentially the entire DEAD-box protein family.
55-in. 8K4K IPS-LCDs with wide viewing angle, high frame frequency, wide color gamut, and stereoscopic (2018)

We have developed an 8K4K liquid-crystal display (LCD) with diagonal size of 55 inch with the backplane based on an amorphous silicon (a-Si) technology. The 8K4K-LCD has high frame frequency at 120 Hz, which is enabled by a unique technology to compensate the charging voltage of pixels. The achievement of a high resolution of 8K4K including high frame frequency of 120 Hz with a-Si backplanes is ground-breaking for LCDs. Furthermore, a backlight system with laser diode as light source expands the color gamut dramatically. This backlight system enables covering 99% of color space recommended in BT.2020. What is more, the 8K4K-LCD has evolved into a three-dimensional (3-D) display device by attaching a 3-D polarizing film. The vertical viewing angle of the 8K-3D LCD prototype is 8.6 deg at its optimal viewing position set to 1.2 m.
Meniscal transplantation and degenerative articular change: An experimental study in the rabbit (1997)

Over the past several decades, scientific evidence has substantiated the vital role of the meniscus in the function of the knee. Using a modified Mankin method, this study evaluated the efficacy of immediate and delayed meniscal transplantation to prevent the degenerative articular changes seen after medial meniscectomy. Significantly fewer degenerative changes occurred in the articular cartilage from New Zealand white rabbits receiving a meniscal transplantation immediately after meniscectomy when compared with control animals killed 3 months after meniscectomy (P < .05). Rabbits who received a delayed transplantation 3 months after meniscectomy and were killed at 6 months, showed significantly fewer degenerative changes in the articular cartilage compared with control animals killed 6 months (P < .05) or 3 months (P < .05) after meniscectomy. These studies show that both immediate and delayed meniscal allograft transplantation offer some initial protection to the cartilaginous surfaces of the knee following meniscectomy. These studies also suggest that delayed meniscal transplantation may reverse initial postmeniscectomy degenerative changes for the short term.
ChemInform Abstract: Combinatorial Chemistry for the Synthesis of Carbohydrate—Carbohydrate Mimics Libraries (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Magnetic resonance imaging analysis of coracoid morphology and its relation to rotator cuff tears. (2002)

The purpose of this study was to define the magnetic resonance imaging (MRI) anatomy of the subcoracoid space and to determine its relation to rotator cuff tears. Routine clinical MRI sequences of 100 shoulders were reviewed, and standardized measurements of the subcoracoid space were taken and compared with previously published computed tomographic (CT) data. MRI and CT values were very similar. There were no significant differences between the coracoid morphology of patients with normal findings and patients with varying degrees of rotator cuff disease involving the supraspinatus tendon. The excellent agreement between MRI and CT measurements indicates that different investigators may use either imaging modality to obtain reproducible results. The role of coracoid anatomy in the development of lesions of the subscapularis tendon and the long head of the biceps remains to be defined.
Advanced detergent formulation design by progressing from hydrophilic/lipophilic balance (HLB) to hydrophilic-lipophilic deviation (HLD) (2022)

Laundry detergent products generally contain 10-30% surfactants as active ingredients and detergency is an essential worldwide activity that the global market is anticipated to reach over $200 billion by 2027 (Research and Market, 2021). While the hydrophilic-lipophilic balance (HLB) concept was initially utilized to design detergency formulations, it does not take into consideration important formulation variables (e.g., salinity, target soil, and temperature). Detergency formulation based on microemulsion phase behavior was then widely employed as an improved formulation design but is time-consuming. More importantly, optimal formulations (optimal salinity (S*) for ionic surfactants and phase inversion temperature for nonionic surfactants) varied widely depending on surfactant systems and the nature of the soil being cleaned. The hydrophilic-lipophilic deviation (HLD) method advances the HLB approach by incorporating formulation variables and has been extensively utilized for microemulsion formation and more recently as a unifying detergency formulation design approach. HLD-based detergency results demonstrated that surfactant formulation approaching HLD of 0 (specifically, between -3 and 0) showed significant detergency improvement for oily and waxy soils with widely varying equivalent alkane carbon numbers (EACNs). Thus, the HLD approach is recommended as a unifying approach for designing effective detergency formulations for a range of surfactant systems and soils.
Photon energy conversion by near-zero permittivity nonlinear materials (2023)

Efficient harmonic light generation can be achieved with ultrathin films by coupling an incident pump wave to an epsilon-near-zero (ENZ) mode of the thin film. As an example, efficient third harmonic generation from an indium tin oxide nanofilm (.lamda./42 thick) on a glass substrate for a pump wavelength of 1.4 .mu.m was demonstrated. A conversion efficiency of 3.3.times.10.sup.-6 was achieved by exploiting the field enhancement properties of the ENZ mode with an enhancement factor of 200. This nanoscale frequency conversion method is applicable to other plasmonic materials and reststrahlen materials in proximity of the longitudinal optical phonon frequencies.
MECHANICAL PULPING: Two-photon autofluorescence spectral imaging applied to probe process-effects in thermomechanical pulp refining (2011)

Article MECHANICAL PULPING: Two-photon autofluorescence spectral imaging applied to probe process-effects in thermomechanical pulp refining was published on December 1, 2011 in the journal Nordic Pulp & Paper Research Journal (volume 26, issue 4).
High-Efficiency Green Phosphorescent Organic Light-Emitting Devices with Chemically Doped Layers (2007)

We have developed green phosphorescent organic light-emitting devices (OLEDs) with high quantum and luminous efficiencies. A green phosphorescent metal complex, fac-tris(2-phenylpyridine) iridium [Ir(ppy)3], was used as an emitter material. Wide-energy-gap materials with high triplet excited energy levels were used as host materials for Ir(ppy)3 and as carrier transport materials. Hole injection and electron injection from the electrodes were balanced by placing chemically doped layers at the interface between the electrodes and the organic layers. In addition, a highly reflective Ag cathode was employed as an anode, instead of a conventional Al cathode to enhance the reflectivity of the cathode metal. An optimized device exhibited an external quantum efficiency (EQE) of 27% (95 cd/A) and a high power efficiency of 97 lm/W at 100 cd/m2 at 3.1 V.
Far field subwavelength imaging of magnetic patterns (2012)

Far field imaging of subwavelength magnetic objects in real time is a very challenging issue. We propose an original solution based on a planar array of closely spaced split ring resonators. Hybridization between the resonators of such metalens induces subwavelength modes with different frequencies. Thanks to these high Q resonating modes, Purcell like effect allows an evanescent source, close to the metalens, to emit waves that can be collected efficiently in the far field. We present the first microwave experimental demonstration of such metalens to image of a subwavelength magnetic pattern. Numerical simulation shows that this approach is still valid at THz frequencies.
Demonstration of Adaptive SDN Orchestration: A Real-Time Congestion-Aware Services Provisioning Over OFDM-Based 400G OPS and Flexi-WDM OCS (2017)

In this Paper, we experimentally demonstrate highly flexible and intelligent interdomain coordinated actions based on adaptive software-defined networking (SDN) orchestration. An advanced multidomain multitechnology testbed is implemented, which consists of a 400-Gb/s variable capacity optical packet switching domain and a Tb/s-class flexi-grid wavelength division multiplexed optical circuit switching domain. The SDN-controllable transponders and the extended transport applications programming interface enable the congestion-aware provisioning of end-to-end real-time services. At the data plane level, different transponders based on orthogonal frequency division multiplexing are employed for inter/intradomain links in order to adaptively provision services with fine granularity. For adaptation, SDN-capable domain-specific optical performance monitors are also introduced. In the control plane, the applications based network operations architecture has been extended and addressed as an adaptive SDN orchestrator.
Second order statistics based blind channel equalization with correlated sources (2002)

In this paper the blind equalization method of Tong, Xu and Kailath, which was derived under the assumption of a white transmitted sequence, is generalized in order to include correlated sources. The resulting algorithm can be applied to arbitrarily colored sources, assuming that the source second-order statistics are known. Because it makes explicit use of this information, the new algorithm is expected to outperform subspace based methods which neither require nor exploit such knowledge. This is verified via simulations.
The Acreo GMPLS Testbed : Current Functionality and a Path Towards a Multi-Flavoured Ethernet Hierarchy (2009)

The Acreo GMPLS Testbed : Current Functionality and a Path Towards a Multi-Flavoured Ethernet Hierarchy
Modeling the Effects of Trapping and Water Alternate Gas (WAG) Injection on Tertiary Miscible Displacements (1988)

ABSTRACT This work investigates the effects that Water Alternate Gas (WAG) injection and trapping of oil by water have on the behavior of tertiary miscible displacements. Insights are offered into some of the trade-offs associated with the competition between improved sweep efficiency and reduced displacement efficiency associated with WAG injection. One dimensional calculations show an insensitivity of displacement efficiency to water injection over a limited range of low WAG ratios. When operating in such a manner, changing the amount of injected water has no effect on the basic solvent-oil displacement process. It only modifies what happens behind the displacement front. Mobility considerations indicate that the solvent-oil displacement is unstable. If enough water is injected with the solvent, a low mobility solvent-water bank is created which moves with the same velocity as the back of the oil bank. The WAG ratio at which these equal bank velocities occur is critical, because injection below this WAG ratio is predicted to give good displacement efficiency and poor sweep, while above this ratio mobility control and increased sweep efficiency will result at the expense of reduced displacement efficiency. In theory, injection at this "equal velocity" WAG ratio should give the benefits of both, good sweep efficiency without a reduction in displacement efficiency due to trapping. This optimum WAG ratio is shown to be relatively insensitive to the assumed level of trapping. Detailed two-dimensional simulations confirm the unstable solvent-oil displacement below the optimum WAG ratio. Mobility control and stabilization of fingers at higher WAG ratios are also confirmed. However, if trapping is important, a corresponding decrease in displacement efficiency occurs· These two-dimensional simulations also provide insight about more correct ways to model tertiary miscible displacements with simpler models, such as a mixing parameter model.
Service Node Architecture Technology for Disaggregated Network Service Functions and Fixed-mobile Convergence Networks (2023)

box hardware and network control software in the cloud to make it possible to softwareize the functions of traditional hardware-centric carrier networks and assemble networks flexibly.This article introduces Beluganos ® , a network operating system (OS) for white box switches, as shown in Fig. 1, and the Value-added Pluggable Network Platform Technology. Overview of NTT's in-house network OS (Beluganos ® )Beluganos ® is being developed to target a wide range of white box network equipment including datacenter switches, carrier routers, and transmission equipment.There are two main advantages to using white box network equipment.One is that hardware and software can be separated, so we can use hardware and software freely.For example, even if the hardware is no longer manufactured, the OS software can continue
Contribution to the Assessment methodology for Connected and Automated Vehicles on Traffic (2018)

TRB 2018, 97th Annual Meeting Transportation Research Board, Washington, ETATS-UNIS, 07-/01/2018 - 11/01/2018
Effect of n‐AlGaN cleave assistance layers on the morphology of c ‐plane cleaved facets for m ‐plane InGaN/GaN laser diodes (2011)

Abstract The effect of thick n‐type Al 0.12 Ga 0.88 N cleave assistance layers (CALs) on the morphology of c ‐plane cleaved facets was investigated for m ‐plane InGaN/GaN laser diode (LD) ridge waveguide structures. Five LD structures with AlGaN CAL thicknesses ranging from 0 to 800 nm were thinned, scribed, cleaved, and characterized via plan view optical microscopy to evaluate the morphology of the cleaved facets. The fraction of facets that appeared straight across the entire width of the ridge waveguides increased with increasing AlGaN CAL thickness, nearly doubling from a minimum of 43% in samples with no AlGaN CAL to a maximum of 85% in samples with a 600 nm AlGaN CAL. (© 2011 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Coherent Random Lasing in Subwavelength Quasi‐2D Perovskites (2023)

Abstract Quasi‐2D lead halide perovskites have garnered increasing interest as lasing gain media. Relatively simple fabrication, high refractive index, and unique quantum well structure encourage their use in traditional cavity lasers and cavity‐free systems called random lasers (RLs). Despite tremendous advances reported thus far, coherent random lasing in quasi‐2D perovskite subwavelength films has not been reported. Consequently, coherent optical feedback mechanisms in quasi‐2D perovskite systems are still unexplored. Here, this work reports the observation of coherent random lasing in subwavelength quasi‐2D perovskite films. Statistical analysis of spectral measurements reveals Lévy‐like intensity fluctuations, replica symmetry breaking confirms random lasing, and the coherent modes are studied with spectral and spatial correlation techniques. The observed coherent lasing modes are found to be extended states that arise from the random crystal grain structure during fabrication and span the entire pump volume. These modes out‐compete diffusive lasing due to their coherence.
ChemInform Abstract: Thermal Allylations of Aldehydes with a Fluorous Allylstannane. Separation of Organic and Fluorous Products by Solid Phase Extraction with Fluorous Reverse Phase Silica Gel. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Methanotrophic Biodegradation of Trichloroethylene in a Hollow Fiber Membrane Bioreactor (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethanotrophic Biodegradation of Trichloroethylene in a Hollow Fiber Membrane BioreactorCarol E. Aziz, Mark W. Fitch, Larry K. Linquist, Jonathan G. Pressman, George. Georgiou, and Gerald E. SpeitelCite this: Environ. Sci. Technol. 1995, 29, 10, 2574–2583Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/es00010a018https://doi.org/10.1021/es00010a018research-articleACS PublicationsRequest reuse permissionsArticle Views271Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Detection of Markov Chain Models from Observed Data using Binary Hypothesis Testing and Consensus (2017)

In this paper we consider the problem of detecting which Markov chain model generates observed time series data. We consider two Markov chains. The state of the Markov chain cannot be observed directly, only a function of the state can be observed. Using these observations, the aim is to find which of the two Markov chains has generated the observations. We consider two observers. Each observer observes a function of the state of the Markov chains. We formulate a binary hypothesis testing problem for each observer. Each observer makes a decision on the hypothesis based on its observations. Then Observer 1 communicates its decision to Observer 2 and vice-versa. If the decisions are the same, then a consensus has been achieved. If their decisions are different then the binary hypothesis testing problem is continued. This process is repeated until consensus has been achieved. We solve the binary hypothesis testing problem and prove the convergence of the consensus algorithm. The "value" of the information gained through 1-bit communication is discussed along with simulation results.
Non‐ATP‐Mimetic Organometallic Protein Kinase Inhibitor (2013)

Non-hinge binding: A novel organometallic protein kinase inhibitor scaffold based on a cyclometalated 1,8-phenanthrolin-7(8 H)-one ligand is reported, which binds to the ATP binding site of the protein kinase Pim1 in an unexpected, unusual non-ATP-mimetic fashion without mimicking the hydrogen-bonding interaction of the adenine nucleobase of ATP.
Effects of relative humidity on capillary force and applicability of these effects in micromanipulation (2008)

This contribution presents the experimental validation of a computational model of capillary forces based on the Laplace equation for the meniscus geometry and on the Kelvin equation for capillary condensation. We apply this to a tip of AFM cantilever ended by a 100 nm curvature tip, and describe the effect of both humidity rate and relative tilt between the cantilever and the substrate. We propose to pick and place components at the considered scale (100 nm) by varying the capillary force.