gebhart/patrepeval huggingface dataset:
Rolling Dissemination and Exploitation Plan and Report (M24). Document Number D7.2 (2011)

Deliverable D2.1 del projecte Europeu FARAMIR (248351)\n\nEl document és Confidencial al projecte europeu FARAMIR, pel que no es pot publicar el seu contingut a E-prints.
28nm Atom-Switch FPGA: Static Timing Analysis and Evaluation (2022)

A static timing analysis (STA) tool for a 28nm atom-switch FPGA (AS-FPGA) is introduced to validate the signal delay of an application circuit before implementation. High accuracy of the STA tool is confirmed by implementing a practical application circuit on the 28nm AS-FPGA. Moreover, dramatic improvement of delay and power is demonstrated in comparison with a previous 40nm AS-FPGA.
Feasibility evaluation of context distribution in mobile environment (2009)

Although mobile devices are rich sources of context information, the distribution of context in mobile environments is often hindered by the limited battery life, and wireless connections with low bandwidth. In this paper, we present two different implementations that enable context distribution in mobile environments. The first solution relies on a presence service architecture and publish-subscribe messaging, whereas the second solution is based on a mobile Web server architecture where the context information is fetched from the mobile device when needed. This paper evaluates the feasibility of the two implementations in mobile context distribution. The testing results show that the mobile server-based solution sets higher demands for the mobile device capabilities, but is able to provide more up-to-date context information. However, the solution based on the centralized context service provides higher interoperability as it utilizes the existing IETF standards.
Enhanced temporal variation of resistive switching memories by insertion of rough titanium oxide thin film (2023)

Artificial intelligence (AI) possesses high adaptability and potential to replace human mental labor. However, only environments with high-performance computing resources and large power supplies can handle AI processing. Current computing technology is based on digital logic devices, leading to the inevitability of endless fetching of data among processors and memories. Moreover, acceleration of AI has been mainly studied at the software level, e.g., pruning of neural networks, which is insufficient for overcoming processing environment restrictions. Meanwhile, in-memory computing by physically composed neural networks is an emerging field. Resistive switching memory (RRAM) is a promising option, which is yet to be implemented because of the stochastic nature of the switching process. In this work, the temporal reliability of tantalum oxide-based RRAM was dramatically enhanced (∼1%) by the insertion of a rough titanium oxide thin film. The enhanced devices exhibited a classification accuracy of ∼88%, showing superior performance and application potential for neuromorphic computing.
Addition of Methylene to Multiple Bonds between Ligand‐Free, Main‐Group Elements and Transition Metals—A General Reaction (1983)

Abstract The complete manuscript of this communication appears in: Angew. Chem. Suppl. 1983 , 1543. DOI: 10.1002/anie.198315430
NK Cells Mediate Synergistic Antitumor Effects of Combined Inhibition of HDAC6 and BET in a SCLC Preclinical Model (2018)

Small-cell lung cancer (SCLC) has the highest malignancy among all lung cancers, exhibiting aggressive growth and early metastasis to distant sites. For 30 years, treatment options for SCLC have been limited to chemotherapy, warranting the need for more effective treatments. Frequent inactivation of TP53 and RB1 as well as histone dysmodifications in SCLC suggest that transcriptional and epigenetic regulations play a major role in SCLC disease evolution. Here we performed a synthetic lethal screen using the BET inhibitor JQ1 and an shRNA library targeting 550 epigenetic genes in treatment-refractory SCLC xenograft models and identified HDAC6 as a synthetic lethal target in combination with JQ1. Combined treatment of human and mouse SCLC cell line-derived xenograft tumors with the HDAC6 inhibitor ricolinostat (ACY-1215) and JQ1 demonstrated significant inhibition of tumor growth; this effect was abolished upon depletion of NK cells, suggesting that these innate immune lymphoid cells play a role in SCLC tumor treatment response. Collectively, these findings suggest a potential new treatment for recurrent SCLC.<b>Significance:</b> These findings identify a novel therapeutic strategy for SCLC using a combination of HDAC6 and BET inhibitors. <i>Cancer Res; 78(13); 3709-17. ©2018 AACR</i>.
Cascade pulse coupled neural network for multimodal medical image fusion (2014)

Welcome to the WIT Press eLibrary - the home of the Transactions of the Wessex Institute collection, providing on-line access to papers presented at the Institute's prestigious international conferences and from its State-of-the-Art in Science & Engineering publications.
Further insight into the mechanism of poly(styrene-co-methyl methacrylate) microsphere formation (2017)

Polymeric microspheres have been utilized in a broad range of applications ranging from chromatographic separation techniques to analysis of air flow over aerodynamic surfaces. The preparation of microspheres from many different polymer families has consequently been extensively studied using a variety of synthetic approaches. Although there are a variety of methods of synthesis for polymeric microspheres, free-radical initiated emulsion polymerization is one of the most common techniques. In this work, poly(styrene-co-methyl methacrylate) microspheres were synthesized via surfactant-free emulsion polymerization. The effect of co-monomer composition and addition time on particle size distribution, particle formation, and particle morphology were investigated. Particles were characterized using dynamic light scattering (DLS) and scanning electron microscopy (SEM) to gain further insight into particle size and size distributions. Reaction kinetics were analyzed alongside of characterization results. A particle formation mechanism for poly(styrene-co-methyl methacrylate) microspheres was proposed based on characterization results and known reaction kinetics.
A37 EFFICACY AND SAFETY OF RISANKIZUMAB AS MAINTENANCE THERAPY IN PATIENTS WITH CROHN’S DISEASE: 52 WEEK RESULTS FROM THE PHASE 3 FORTIFY STUDY (2022)

Abstract Background Risankizumab (RZB), an anti-IL-23 p19 inhibitor, was well-tolerated and superior to placebo (PBO) in inducing clinical remission and endoscopic response in patients (pts) with moderate-to-severe Crohn’s disease (CD) in two phase 3 studies at 12 weeks. Aims FORTIFY (NCT03105102), was a 52-week (wk) phase 3 double-blind, re-randomized responder withdrawal study that evaluated the efficacy and safety of continuing RZB as subcutaneous (SC) maintenance therapy versus withdrawal to placebo in pts achieving induction response to RZB Methods Week 12 IV RZB responders were re-randomized 1:1:1 to: RZB SC 360mg (N=141), RZB 180mg (N=157), or PBO (withdrawal from IV RZB; N=164) every 8wks for 52wks. Co-primary endpoints were clinical remission (per CD Activity Index [CDAI] (US); or stool frequency/abdominal pain score [SF/APS] (OUS) and endoscopic response at wk52. Other clinical and endoscopic endpoints, inflammatory biomarkers, RZB serum levels, and safety were assessed over time. Results Rates of clinical remission (CDAI, SF/APS) and clinical response were similar for RZB and PBO groups through wk24, with rates lower for PBO thereafter. At wk52, clinical remission (CDAI, SF/APS) and endoscopic response rates were significantly higher with RZB 360mg than PBO ( P&amp;lt;0.01); RZB 180mg was superior to PBO for clinical remission per CDAI and endoscopic response ( P&amp;lt;0.01). Endoscopic remission and deep remission rates increased over time with 360mg, remained steady with 180mg, and decreased with PBO. Mean fecal calprotectin (FCP) and C-reactive protein (CRP) levels decreased with SC RZB, but increased with PBO, over 52wks. Exposure-adjusted event rates (per 100 pts-years) of serious adverse event (AE) were generally similar among groups (360mg, 21.0 E/100PY and 180mg, 19.5 E/100PY vs PBO, 19.3 E/100PY), as were AEs leading to drug discontinuation (4.8 E/100PY and 2.4 E/100PY vs 3.7 E/100PY), and serious infections (6.0 E/100PY and 3.0 E/100PY vs 5.0 E/100PY). Conclusions In pts with moderate-to-severe CD, a robust pharmacodynamic effect on the IL-23 pathway after 12wks RZB IV induction was maintained with RZB SC maintenance therapy. The durability of RZB was demonstrated with high rates of efficacy over the 52-wk study. RZB was superior to PBO for achieving clinical remission and endoscopic response at wk52. Results for the more stringent endpoints (endoscopic remission\deep remission) and persistent improvements in inflammatory biomarkers are consistent with a dose response relationship. Continued RZB SC maintenance treatment was generally safe and well-tolerated. Funding Agencies AbbVie
Enhancement of optical absorption in solar cells by band-edge effect of photonic crystals. II &#x2014; Topology optimization for further absorption (2013)

We investigate optical absorption enhancement in a solar cell structure using photonic crystals. We propose and investigate topology optimization for photonic crystal design and successfully find a structure with larger optical absorption.
Bandpass filter with N&#x002B;1 transmission zeroes using frequency-variant couplings (2010)

A bandpass filter topology which can generate N+1 transmission zeroes is presented. These zeroes are created using frequency-variant couplings. A design procedure, derived from the transmission line equivalent circuit, is described and used to evaluate a first approximation of the filter dimensions. The final dimensions are obtained with an optimization routine in order to take into account the frequency variation of the couplings. The experimental validation presented shows that the proposed topology can provide an improved out-of-band rejection compared to conventional filters. The order 3 bandpass filter centered at 10 GHz, with 4 transmission zeroes at 8, 9, 11, and 12 GHz, presents an insertion loss of 1.9 dB for a 500 MHz bandwidth.
KalmanNet: Neural Network Aided Kalman Filtering for Partially Known Dynamics (2021)

State estimation of dynamical systems in real-time is a fundamental task in signal processing. For systems that are well-represented by a fully known linear Gaussian state space (SS) model, the celebrated Kalman filter (KF) is a low complexity optimal solution. However, both linearity of the underlying SS model and accurate knowledge of it are often not encountered in practice. Here, we present KalmanNet, a real-time state estimator that learns from data to carry out Kalman filtering under non-linear dynamics with partial information. By incorporating the structural SS model with a dedicated recurrent neural network module in the flow of the KF, we retain data efficiency and interpretability of the classic algorithm while implicitly learning complex dynamics from data. We demonstrate numerically that KalmanNet overcomes non-linearities and model mismatch, outperforming classic filtering methods operating with both mismatched and accurate domain knowledge.
The first 3-dimensional assemblies of organotin-functionalized polyanions (2009)

Reaction of the (CH(3))(2)Sn(2+) electrophile toward trilacunary [A-alpha-XW(9)O(34)](n-) Keggin polytungstates (X = P(V), As(V), Si(IV)) with guanidinium as templating-cation resulted in the isostructural compounds Na[C(NH(2))(3)](2)[{(CH(3))(2)Sn(H(2)O)}(3)(A-alpha-PW(9)O(34))] x 9 H(2)O (1), Na[C(NH(2))(3)](2)[{(CH(3))(2)Sn(H(2)O)}(3)(A-alpha-AsW(9)O(34))] x 8 H(2)O (2) and Na(2)[C(NH(2))(3)](2)[{(CH(3))(2)Sn(H(2)O)}(3)(A-alpha-SiW(9)O(34))] x 10 H(2)O (3). Compounds 1-3 constitute the first 3-dimensional assemblies of organotin-functionalized polyanions, as well as the first example of a dimethyltin-containing tungstosilicate in the case of 3, and they show a similar chiral architecture based on tetrahedrally-arranged {(CH(3))(2)Sn}(3)(A-alpha-XW(9)O(34)) monomeric building-blocks connected via intermolecular Sn-O=W bridges regardless of the size and/or charge of the heteroatom.
1.64 µm pulsed source for a distributed opticalfibre Raman temperature sensor (1996)

The authors propose a novel source for distributed anti-Stokes Raman temperature sensing. A source generating 8 W, 10 ns pulses at 500 Hz, at λ = 1.64 µm is demonstrated. Operation at 1.64 µm enables the temperature dependent anti-Stokes signal at 1.53 µm to be generated in the low-loss window, facilitating a long range sensor.
5GEx: realising a Europe‐wide multi‐domain framework for software‐defined infrastructures (2016)

Abstract Market fragmentation has resulted in a multitude of network and cloud/data center operators, each focused on different countries, regions and technologies. This makes it difficult and costly to create infrastructure services spanning multiple domains, such as virtual connectivity or compute resources. In this article, we discuss the goals and work being done within the 5GEx (5G Exchange) project in realising a Europe‐wide multi‐domain platform. This platform aims at enabling cross‐domain orchestration of services over multiple administrations or over multi‐domain single administrations in the context of emerging 5G networking. The 5GEx vision is based on introducing a unification via network function virtualisation/software‐defined networking compatible multi‐domain orchestration for networks, clouds and services. We describe the motivation and 5GEx vision, the adopted architecture and the next steps in terms of implementation and experimentation. Copyright © 2016 John Wiley &amp; Sons, Ltd.
Long-Term Outcomes of Reverse Total Shoulder Arthroplasty (2017)

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Matériaux pour l'optique élaborés para le procédé sol-gel. III : Propriétés électrochromes (1992)

espanolA partir de ciertos oxidos de metales de transicion sometidos a polarizacion negativa es posible la formacion de compuestos de valencia mixta que generan intensa absorcion en la parte visible del espectro optico dando lugar a una intensa coloracion que puede usarse en dispositivos electrocromicos. Usando el proceso sol-gel se pueden sintetizar numerosos compuestos electrocromicos tales como: M0O3, V2O5, Nb205, TIO2, Ir02 o NiO. Se describen en este trabajo los procesos de obtencion y las propiedades de tres oxidos elaborados por procesos sol-gel, tales como: V2O5, TIO2, WO3 EnglishFrom several transition oxides submissed to negative polarization it is possible the formation of mixed, valence compunds wich give rise to strong absorption in the visible area of the optical spectrum. These compunds produce an intense colouration applied in electrochromic instruments. By using the sol-gel processing it is possible to synthetize several compunds with electrochromic properties such as = M0O3, V2O5, NbjOg, TiOj, IrOj or NiO. This paper describes the obtention processes and the properties of three oxides produced via sol-gel, such as: V2O5, TIO2 and WO3.
Asymmetric Synthesis of Diazepino‐β‐lactams by [2 + 2] Cycloaddition of an ‘Evans‐Sjogven’ Ketene with 1H‐1,2‐Diazepines (1991)

Abstract The ketene derivative of the chiral oxazolidinone 1 underwent non‐concerted stereo specific [2 + 2] cycloadditions with the ( Z )‐imine moiety of diazepines 2 , leading thereby with good diastereoselection to the trans ‐β‐lactam adducts 3 (major) and 4 (minor). The absolute configuration of the major cycloadduct 3a was determined by an X‐ray analysis. Its formation is discussed in terms of minimisation of steric interaction in the two transition states which give sequencially the zwitterionic intermediates and the final cycloadducts.
Activity of influenza C virus O-acetylesterase with O-acetyl-containing compounds (1991)

Influenza C virus (strain C/Johannesburg/1/66) was grown, harvested, purified and used as source for the enzyme O-acetylesterase (N-acyl-O-acetylneuraminate O-acetylhydrolase; EC 3.1.1.53). This activity was studied and characterized with regard to some new substrates. The pH optimum of the enzyme is around 7.6, its stability at different pH values shows a result similar to that of the pH optimum, and its activity is well maintained in the pH range from 7.0 to 8.5 (all these tests were performed with 4-nitrophenyl acetate as substrate). Remarkable differences were found in the values of both Km and Vmax, with the synthetic substrates 4-nitrophenyl acetate, 2-nitrophenyl acetate, 4-methylumbelliferyl acetate, 1-naphthyl acetate and fluorescein diacetate. The use of 4-nitrophenyl acetate, 4-methylumbelliferyl acetate or 1-naphthyl acetate as substrate seems to be convenient for routine work, but it is better to carry out the measurements in parallel with those on bovine submandibular gland mucin (the latter is a natural and commercially available substrate). It was found that 4-acetoxybenzoic acid, as well as the methyl ester of 2-acetoxybenzoic acid, but not 2-acetoxybenzoic acid itself, are cleaved by this enzyme. Triacetin, di-O-acetyladenosine, tri-O-acetyladenosine, and di-O-acetyl-N-acetyladenosine phosphate, hitherto unreported as substrates for this viral esterase, are hydrolysed at different rates by this enzyme. We conclude that the O-acetylesterase from influenza C virus has a broad specificity towards both synthetic and natural non-sialic acid-containing substrates. Zn2+, Mn2+ and Pb2+ (as their chloride salts), N-acetylneuraminic acid, 4-methyl-umbelliferone and 2-acetoxybenzoic acid (acetylsalicylic acid) did not act as inhibitors.
A theory of wormhole routing in parallel computers (1992)

Virtually all theoretical work on message routing in parallel computers has dwelt on packet routing: messages are conveyed as packets, an entire packet can reside at a node of the network, and a packet is sent from the queue of one node to the queue of another node until its reaches its destination. The current trend in multicomputer architecture, however, is to use wormhole routing. In wormhole routing a message is transmitted as a contiguous stream of bits, physically occupying a sequence of nodes/edges in the network. Thus, a message resembles a worm burrowing through the network. The authors give theoretical analyses of simple wormhole routing algorithms, showing them to be nearly optimal for butterfly and mesh connected networks. The analysis requires initial random delays in injecting messages to the network. They report simulation results suggesting that the idea of random initial delays is not only useful for theoretical analysis but may actually improve the performance of wormhole routing algorithms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Still-image watermarking robust to local geometric distortions (2006)

Geometrical distortions are the Achilles heel for many watermarking schemes. Most countermeasures proposed in the literature only address the problem of global affine transforms (e.g., rotation, scaling, and translation). In this paper, we propose an original blind watermarking algorithm robust to local geometrical distortions such as the deformations induced by Stirmark. Our method consists in adding a predefined additional information to the useful message bits at the insertion step. These additional bits are labeled as resynchronization bits or reference bits and they are modulated in the same way as the information bits. During the extraction step, the reference bits are used as anchor points to estimate and compensate for small local and global geometrical distortions. The deformations are approximated using a modified basic optical flow algorithm.
360Role of cardioversion in the management of non-valvular atrial fibrillation: insights from the GARFIELD-AF registry (2018)

Innovative drug therapies / Treatment of atrial fibrillation 51 effect of nicorandil, sarcolemmal KATP channel selective blocker (Cibenzoline, 1mg/kg/d, abcam, No: ab145975) and mitochondrial KATP channel blocker (5hydroxydecanoate, 10 mg/kg/d, sigma, No: 71186-53-3) were injected intraperitoneally daily 10 min before nicorandil treatment in two subgroups. Mitochondria isolated from hearts, while ATP assay (using an ATP assay kit, FLAA, Sigma, USA) and reactive oxygen species (ROS) assay (MAK143, Sigma, USA) were performed respectively. Caspase3, PGC-1, Glut-4 and five complex of oxidative phosphorylation in mictochondria were detected by Western blot. Meanwhile, myocardial apoptosis was also detected by TUNEL staining. Results: Compared with sham-operation group, TAC groups had significantly worse cardiac function (LVEF: 31.84.8% vs. 67.23.2%, P<0.01). Nicorandil treatment not only improved LVEF (LVEF: 52.35.8%vs. 31.84.8%, P<0.01), but also reduced the ratio of heart and body weight (0.630.06 vs. 0.810.14, P<0.01). Nicorandil also increased myocardial ATP synthase and reduced ROS. However, in Cibenzoline or 5-hydroxydecanoate subgroups, the protective effect of nicorandil was significantly eliminated. We also found that the average number of apoptotic cardiomyocyte nuclei and cleaved-caspase3 expression, which were improved in nicorandil group, were significantly elevated in nicorandil combined with Cibenzoline or 5-hydroxydecanoate subgroups again. Myocardial expression of PGC-1 and Glut-4 detected by Western blot was also reduced in TAC group, which was significantly increased after nicorandil treatment. Conclusions: KATP opener nicorandil protected against pressure-overloadinduced cardiac dysfunction, which were associated with myocardial apoptosis improvement and energy metabolism recovery.
Improved performance of MIMO antenna systems for various fading channels (2012)

This paper presents the design and performance analysis of MIMO antennas for wireless communication systems. The 2 × 2 MIMO system process applies an adaptive approach in order to reduce the impact of wireless channel impairments such as multipath fading. The MIMO system was applied in AWGN and single Rayleigh fading channel that uses QPSK modulation schemes to simulate the BER performance for QPSK in MIMO system and finally compares BER results with SISO and MISO systems.