gebhart/patrepeval huggingface dataset:
Gas chromatography/mass spectrometric and nuclear magnetic resonance determination of polynuclear aromatic hydrocarbons in airborne particulates (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas chromatography/mass spectrometric and nuclear magnetic resonance determination of polynuclear aromatic hydrocarbons in airborne particulatesM. L. Lee, M. Novotny, and K. D. BartleCite this: Anal. Chem. 1976, 48, 11, 1566–1572Publication Date (Print):September 1, 1976Publication History Published online1 May 2002Published inissue 1 September 1976https://pubs.acs.org/doi/10.1021/ac50005a037https://doi.org/10.1021/ac50005a037research-articleACS PublicationsRequest reuse permissionsArticle Views321Altmetric-Citations130LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Running Xen: A Hands-On Guide to the Art of Virtualization (2008)

This accessible and immediately useful book expertly provides the Xen community with everything it needs to know to download, build, deploy and manage Xen implementations. Ian Pratt, Xen Project Leader VP Advanced Technology, Citrix Systems The RealWorld, 100% Practical Guide to Xen Virtualization in Production Environments Using free, open source Xen virtualization software, you can save money, gain new flexibility, improve utilization, and simplify everything from disaster recovery to software testing. Running Xen brings together all the knowledge you need to create and manage highperformance Xen virtual machines in any environment. Drawing on the unparalleled experience of a worldclass Xen team, it covers everything from installation to administrationsharing field-tested insights, best practices, and case studies you can find nowhere else. The authors begin with a primer on virtualization: its concepts, uses, and advantages. Next, they tour Xens capabilities, explore the Xen LiveCD, introduc e the Xen hypervisor, and walk you through configuring your own harddiskbased Xen installation. After youre running, they guide you through each leading method for creating guests and migrating existing systems to run as Xen guests. Then they offer comprehensive coverage of managing and securing Xen guests, devices, networks, and distributed resources. Whether youre an administrator, data center manager, developer, system integrator, or ISP, Running Xen will help you achieve your goals with Xenreliably, efficiently, with outstanding performance, and at a surprisingly low cost. Understanding the Xen hypervisor: what it does, and how it works Using pre-built system images, including compressed file systems Managing domains with the xm console Populating and storing guest images Planning, designing, and configuring networks in Xen Utilizing Xen security: special purpose VMs, virtual network segments, remote access, firewalls, network monitors, sHype access control, Xen Security Modules (XSM), and more Managing guest resources: memory, CPU, and I/O Employing Xen in the enterprise: tools, products, and techniques
Computational data related to "Digital Navigation of Energy Structure function Maps for Hydrogen-Bonded Porous Molecular Crystals" (2021)

Computational data related to landscapes of predicted crystal structures reported in Digital Navigation of Energy–Structure–Function Maps for Hydrogen-Bonded Porous Molecular Crystals
Functional high efficiency expression of cloned leucocyte chemoattractant receptor cDNAs (1992)

Human kidney 293 TSA cells were transfected by a calcium phosphate method with human formylpeptide and C5a receptor cDNAs with high efficiency. Formylpeptide receptor positive transfectants expressed a total of 968,000 +/- 34,000 receptors per cell with two affinity states (Kds of ca. 0.43 nM and 39 nM), which in the presence of 100 microM GTP gamma S decreased by ca. 4-fold the number of high-affinity sites. The ligand binding pharmacology of cloned and expressed formylpeptide receptors were indistinguishable from endogenous receptors on human neutrophils. Expressed formylpeptide and C5a receptors were functionally active in mobilizing intracellular calcium via a pertussis toxin sensitive mechanism with an ED50 for formylpeptide of ca. 0.5-1.0 nM. This expression system, in which receptor expression can be monitored by flow cytometric methods and in which intracellular calcium responses are measurable, unlike in the more popular COS-7 cell expression system, will provide a useful basis for the analysis of chemoattractant receptor structure-function relationships.
Experimental study of sub-DSA resolution assist features (SDRAF) (2015)

Cylindrical directed self-assembly (DSA) nanostructures is a promising candidate for patterning the contacts and vias in integrated circuits. To match the contact patterns in an IC layout, physical guiding templates have been adopted to generate aperiodic DSA patterns, and templates of different sizes could lead to various DSA patterns. It is found in the experiment that the density of guiding templates has a strong influence on the DSA patterns. At a low template density, templates tend to become overfilled and result in DSA defects. In this paper, we experimentally demonstrate an effective solution to counteract the influence of template pattern density on the quality of DSA using sub-DSA-resolution Assist Features (SDRAFs). We show that SDRAFs can reduce the DSA defects significantly.
Plasma etching of cesium iodide (2002)

Thick films of cesium iodide (CsI) are often used to convert x-ray images into visible light. Spreading of the visible light within CsI, however, reduces the resolution of the resulting image. Anisotropic etching of the CsI film into an array of micropixels can improve the image resolution by confining light within each pixel. The etching process uses a high-density inductively coupled plasma to pattern CsI samples held by a heated, rf-biased chuck. Fluorine-containing gases such as CF4 are found to enhance the etch rate by an order of magnitude compared to Ar+ sputtering alone. Without inert-gas ion bombardment, however, the CF4 etch becomes self-limited within a few microns of depth due to the blanket deposition of a passivation layer. Using CF4+Ar continuously removes this layer from the lateral surfaces, but the formation of a thick passivation layer on the unbombarded sidewalls of etched features is observed by scanning electron microscopy. At a substrate temperature of 220 °C, the minimum ion-bombardment energy for etching is Ei∼50 eV, and the rate depends on Ei1/2 above 65 eV. In dilute mixtures of CF4 and Ar, the etch rate is proportional to the gas-phase density of atomic fluorine. Above 50% CF4, however, the rate decreases, indicating the onset of net surface polymer deposition. These observations suggest that anisotropy is obtained through the ion-enhanced inhibitor etching mechanism. Etching exhibits an Arrhenius-type behavior in which the etch rate increases from ∼40 nm/min at 40 °C to 380 nm/min at 330 °C. The temperature dependence corresponds to an activation energy of 0.13±0.01 eV. This activation energy is consistent with the electronic sputtering mechanism for alkali halides.
Model Based Test Generation for Microprocessor Architecture Validation (2007)

Functional validation of microprocessors is growing in complexity in current and future microprocessors. Traditionally, the different components (or validation collaterals) used in simulation based validation, like simulators and test generators, to validate the system, architecture, microcode, and RTL abstractions of the processor, were manually derived from the specification document. The incomplete informal specification document along with manual translation introduces inconsistency and bugs in the validation collaterals, resulting in increased cost and time to validate the processor. We envision a novel metamodeling based microprocessor modeling and validation environment (MMV) to address this problem. MMV provides a language independent modeling environment to describe the processor at various abstraction levels, a refinement flow to consistently move from one abstraction to the next lower abstraction and code generators to automatically generate the validation collaterals from the models. As a first step towards our vision, in this paper, we describe architectural modeling in MMV and automatic generation of random and coverage directed test suites from the models. We demonstrate the practicality of our approach for validating real world instruction set architectures (ISA) by modeling and generating test cases for eight complex instructions from Intel <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> reg virtualization technology
Conjugates of Gadolinium Complexes to Bile Acids as Hepatocyte-Directed Contrast Agents for Magnetic Resonance Imaging (2004)

A series of structurally different Gd(III) conjugates incorporating a bile acid moiety have been prepared. Polyaminopolycarboxylic ligands such as diethylenetriaminepentaacetic acid (DTPA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid (DOTA) have been selected as chelating subunit for the Gd(III) ion. Cholic acid, cholylglycine, and cholyltaurine have been incorporated as the bile acid moieties. In first generation conjugates the Gd(III) complex is linked to the carboxyl group of cholic acid. Second generation conjugates feature the attachment of the Gd(III) complex to the 3 position of the steroidic backbone of the bile acid. Finally, in third generation conjugates the Gd(III) complex is attached to the epsilon nitrogen atom of cholyllysine. The conjugates are eliminated through the biliary route to a various extent (7.5 to 77% in rats) according to their structural features. Among the most promising terms, a second generation conjugate in which the Gd(III) complex is linked to cholic acid through the 3alpha hydroxy group seems to enter hepatocytes using the Na(+)/taurocholate transporter. Noticeably, some of the second generation conjugates are characterized by very high tolerabilities (LD(50) up to 9.5 mmol/kg) after intravenous administration in mice.
Central Sleep-disordered Breathing Predicts Incident Atrial Fibrillation in Older Men (2015)

In older men, central apnea and Cheyne-Stokes respiration predicted increased atrial fibrillation risk, with findings being strongest in older participants in whom overall sleep-disordered breathing also increased atrial fibrillation risk.
Fluid-measurement technology using flow birefringence of nanocellulose (2019)

We propose a potential fluid-measurement technology aimed at supporting biomechanics research of water sports using fluid simulation and motion analysis. Cellulose nanofibers introduced into the water as tracer particles to visualize the movement of water. An optical property of nanofibers, called flow birefringence, makes water flows brighter than their surroundings when placed between right and left circularly polarized plates. We tested the capability of the technology in a water tank and succeeded in using an existing particle-tracking method-particle image velocimetry (PIV)-to measure the flows from a pump in the tank.
DEMENTIA-LIKE SYMPTOMS IN ELDERLY SCHIZOPHRENIC PATIENTS (1992)

Davidson, M.; Powchik, P.; Haroutunian, V.; Harvey, P. D.; Perl, D.; Losonczy, M. S.; Freske, E.; Bierer, L.; Mohs, R. C.; Davis, K. L. Author Information
21016 Effect of Droplet Temperature on Droplet Curvature during Dropwise Condensation (2010)

PCCS (Passive Containment Cooling System) is one of decay heat removal systems which run automatically after nuclear reactor core flooding case of LOCA (Loss of Coolant Accident). It is necessary for investigation of its cooling characteristics to evaluate the heat transfer coefficient on its cooling surface. For estimation of augmented heat transfer rate on the cooling surface, it is necessary to consider a contribution of drop-wise condensation on its heat transfer rate in addition to that of general film-wise condensation, which has been treated as some comparatively simple models. Purpose of this study is to measure droplet diameters and droplet number densities, which are parameters related to the drop-wise condensation heat transfer. The experimental set-up was constructed for evaluation of above parameters, which are referred to develop some correlation equations for the condensation heat transfer, hi this experiment, a air concentrations and surface subcooling degrees are varied within 0-25% and 5-20K respectively. Some images which show droplet behaviors are obtained for the above conditions, by using high-speed camera and Doughnut-arranged LED illuminations. And their behaviors are compared with that in some cases with existence of non-condensational gases.
A TRANSISTORLESS MICROMECHANICAL HIGH VOLTAGE GENERATOR USING A DC-POWERED SELF-OSCILLATING RELAY (2004)

This paper describes a DC powered high voltage generator that neither uses transistors nor requires a clock signal for its operation. The system, that operates on the principle of an induction coil voltage converter, is assembled using a self-oscillating mechanical relay and a wire wound inductance. Two versions of this high voltage generator have been implemented. The first version, assembled to have a footprint of less than 4 mm x 4 mm, uses an inductor and generates peak voltages > 200 V from a 4 V DC supply. An alternate version uses a transformer that provides electrical isolation and has been used to generate peak voltages > 500 V with a peak voltage gain > 300. The self oscillating relay is fabricated using low temperature UV-LIGA process, that can be appended to a CMOS process. Experimental results used to characterize system performance show that the self oscillating relay consumes not more than 15 % of input power. Circuit simulations closely track observed experimental trends.
Implanted Muscle-Derived Stem Cells Ameliorate Erectile Dysfunction in a Rat Model of Type 2 Diabetes, but Their Repair Capacity Is Impaired by Their Prior Exposure to the Diabetic Milieu (2016)

MDSCs from pre-diabetic rats injected into the corpora cavernosa of rats with long-term T2D improve corporal veno-occlusive dysfunction and the underlying histopathology. In contrast, MDSCs from rats with long-term uncontrolled T2D are imprinted by the hyperglycemic and dyslipidemic milieu with a noxious phenotype associated with an impaired tissue repair capacity. SCs affected by diabetes could lack tissue repair efficacy as autografts and should be reprogrammed in vitro or substituted by SCs from allogenic non-diabetic sources.
Transbronchial microwave ablation: feasibility and safety assessment in a porcine model (2021)

<b>Objective:</b> Assess the feasibility and safety of virtual bronchoscopy-guided transbronchial microwave ablation in normal pig lung using radiologic and histologic evaluation. <b>Methods:</b> We performed virtual bronchoscopy-guided thermal ablation (90W, 5min) in 4 pigs with a custom microwave catheter. Pigs were euthanized at 2 (n=2) and 13 days (n=2) post-ablation. CT scans were taken prior to euthanasia, and also at day 2 for the 13 day group. Ablated and adjacent lung tissue was excised, stained with TTC for macroscopic viability analysis, and formalin-fixed for H&amp;E staining and microscopic analysis. <b>Results:</b> No adverse events were observed during ablation procedures and pigs maintained normal behavior and appetite through the survival period. At day 2, CT imaging overestimated ablation diameter compared to macroscopic analysis, likely due to inflammation obscuring the ablation boundary. At day 13, the CT measurement corresponded with the macroscopic analysis. Measurements provided in Table 1. At day 2, microscopic analysis identifies a central zone of thermal fixation (absence of erythrocytes and maintained architecture) with remnant alveoli filled with edema and fibrin, a surrounding marginal zone of hemorrhage and edema, and a peripheral zone with intra-alveolar macrophages and less edema. At day 13, a 1-2mm granulation tissue rim separates the ablation zone from adjacent aerated lung; the central zone is similar to day 2. <b>Table 1:</b> Ablation diameters from CT and macroscopic analysis <b>Conclusions:</b> We demonstrated the feasibility and safety of delivering bronchoscopy guided pulmonary microwave ablation in a porcine model.
IC‐P‐002: Near infrared fluorescence imaging of cerebral beta‐amyloid plaques with BODIPY‐based molecular probes (2012)

The formation of β -amyloid (Aβ)plaques is critical neurodegenerative change in Alzheimer's disease (AD). The quantitative evaluation of Aβ plaques in the brain with non-invasive techniques could lead to the presymptomatic detection of AD or monitoring of the progression and effectiveness of novel treatments that are currently being investigated. In particular, several PET imaging probes have shown the feasibility of in vivo imaging of Aβ plaques in AD brains. Conversely, there have been fewer reports regarding the development of fluorescent probes than PET probes. Compounds containing a boron dipyrromethane (BODIPY) scaffold have widespread applications as fluorescent probes in biological systems. In this study, we designed and synthesized new BODIPY-based Aβ probes (BAPs) and evaluated their utility for optical imaging of cerebral Aβ plaques. We synthesized some BAPs and evaluated their fluorescent properties. The affinity for Aβ plaques was assessed by an in vitro binding assay using preformed synthetic Aβ(1-42) aggregates. Neuropathological fluorescent staining with BAPs was carried out using brain sections from AD model mice (Tg2576). To test the brain uptake, we determine the fluorescent intensity in the brain after injection of BAP into normal mice. We carried out ex vivo using a Tg2576 mice and wild-type mice. BAPs exhibited absorption, excitation and emission wavelength of 604-665 nm, 614-663 nm and 648-723 nm, respectively, with a high quantum yield (4.3-46.8%). In binding experiments in vitro, BAPs showed excellent affinity for synthetic Aβ aggregates (K d = 18.1-149 nM). Furthermore, BAPs clearly stained Aβ plaques in sections of Tg2576 mice. In evaluation of the brain uptake, BAPs showed sufficient brain uptake for optical imaging. In addition, ex vivo fluorescent staining of brain sections from Tg2576 mice after injection of BAPs showed selective binding of Aβ plaques with little nonspecific binding. The results suggest that BAPs penetrated the blood-brain barrier and selectively labeled the Aβ plaques in the Tg2576 mouse brain, as reflected by the evaluation of brain uptake and in vitro binding assays. BAPs may be useful fluorescent probes for optical imaging of Aβ plaques in AD brains.
Bispecific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia (2020)

Chimeric antigen receptor (CAR) T cells have radically improved the treatment of B cell-derived malignancies by targeting CD19. The success has not yet expanded to treat acute myeloid leukemia (AML). We developed a Sequentially Tumor-Selected Antibody and Antigen Retrieval (STAR) system to rapidly isolate multiple nanobodies (Nbs) that preferentially bind AML cells and empower CAR T cells with anti-AML efficacy. STAR-isolated Nb157 specifically bound CD13, which is highly expressed in AML cells, and CD13 CAR T cells potently eliminated AML in vitro and in vivo. CAR T cells bispecific for CD13 and TIM3, which are upregulated in AML leukemia stem cells, eradicated patient-derived AML, with much reduced toxicity to human bone marrow stem cells and peripheral myeloid cells in mouse models, highlighting a promising approach for developing effective AML CAR T cell therapy.
Enalapril Associated with Furosemide Induced Acute Kidney Injury in an Infant with Heart Failure. A Case Report, a Revision of the Literature and a Pharmacovigilance Database Analysis (2015)

The use of angiotensin converting enzyme (ACE) inhibitors in combination with diuretics is a common strategy used for the treatment of patients affected by heart failure. An infant affected by initial congestive cardiac failure, after starting the treatment with enalapril in association with furosemide, developed acute kidney injury (AKI). No underlying renal disease or renal artery stenosis was found. He recovered from kidney injury after the therapy was suspended, thus suggesting that the drug combination is responsible for the onset of the adverse reaction. The present case report, the appraisal of the current knowledge on the onset of AKI and the analysis of available pharmacovigilance databases indicate that particular caution should be exercised when infants affected by heart failure are treated with the enalapril and furosemide combination therapy. Moreover, we strongly suggest an up-to-date revision of the ACE-inhibitor dosing guidelines in pediatric patients to define unambiguously the safe upper limits of this class of drugs.
1.3 μm High-Power Short-Cavity VCSELs for High-Speed Applications (2012)

InP-based 1.3μm VCSELs employing two dielectric DBRs are presented. Because of reduced internal losses in the DBRs, high slope-efficiencies above 70%, and output-powers of 4.8mW are reported. The same devices feature modulation bandwidths beyond 12GHz.
Nitric Oxide Synthesis from l-Arginine Modulates Renal Vascular Resistance in Isolated Perfused and Intact Rat Kidneys (1991)

Summary: This study tested the effects on renal hemodynamics of blockade of nitric oxide (NO) synthesis from l-arginine with NG-methyl-l-arginine (l-NMA) using both intact and isolated perfused rat kidneys. Infusion of l-NMA into anesthetized rats increased the mean arterial pressure and reduced the glomerular filtration rate and renal plasma flow only when the renal perfusion pressure was maintained at control levels. In isolated kidneys, l-NMA increased vascular resistance; this was attenuated by coadministration of l-arginine. l-NMA selectively inhibited acetylcholine-induced renal vasodilation without attenuating that elicited by sodium nitroprusside. We conclude that basal production of NO within both the intact and isolated kidney is required to maintain the normally high levels of renal blood flow and glomerular filtration and that endothelium-derived NO is an important regulator of renal vascular resistance.