gebhart/patrepeval huggingface dataset:
Weak approxamation of stochastic delay (2006)

Wir betrachten die stochastische Differentialgleichung mit Gedächtnis (SDDE) mit Gedächtnislänge r dX(t) = b(X(u);u in [t-r,t])dt + sigma(X(u);u in [t-r,t])dB(t) mit eindeutiger schwacher Lösung. Dabei ist B eine Brownsche Bewegung, b and sigma sind stetige, lokal beschränkte Funktionen mit Definitionsbereich C[-r,0], und X(u);u in [t-r,t] bezeichnet das Segment der Werte von X(u) für Zeitpunkte u im Intervall [t,t-r]. Unser Ziel ist eine Folge von diskreten Zeitreihen Xh höherer Ordung zu konstruieren, so dass mit h gegen 0 die Zeitreihen Xh schwach gegen die Lösung X der stochastischen Differentialgleichung mit Gedächtnis konvergieren. Desweiteren werden wir Bedingungen angeben, unter denen eine gegeben Folge von Zeitreihen Xh höherer Ordung schwach gegen die Lösung X einer stochastischen Differentialgleichung mit Gedächtnis konvergiert. Als ein Beispiel werden wir den schwachen Grenzwert einer Folge von diskreten GARCH-Prozessen höherer Ordnung ermitteln. Dieser Grenzwert wird sich als schwache Lösung einer stochastischen Differentialgleichung mit Gedächtnis herausstellen.
EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling (2010)

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), originally identified as the major receptor for oxidized low-density lipoprotein (oxLDL) in endothelial cells, plays a major role in the pathology of vascular diseases. Green tea consumption is associated with reduced cardiovascular mortality in some epidemiological studies. In the present study, we hypothesized that the most abundant polyphenolic compound in tea, epigallocatechin-3-gallate (EGCG), can downregulate parameters of endothelial dysfunction by modulating LOX-1-regulated cell signaling. In cultured human umbilical vein endothelial cells (HUVECs), exposure to oxLDL (130 microg/ml), which led to an increase in LOX-1 expression at the RNA and protein levels, was abrogated by addition of EGCG or DPI, a well-known inhibitor of flavoproteins, suggesting the involvement of NADPH oxidase. Furthermore, oxLDL rapidly activated the membrane translocation of Rac-1 and p47phox and the subsequent induction of ROS generation, which was suppressed markedly by pretreatment with EGCG or anti-LOX-1 monoclonal antibody. OxLDL also increased p38 MAPK phosphorylation and decreased phosphorylation of the amino-terminal region of Akt, with maximal induction at about 30 min, and NF-kappaB phosphorylation within 1 h, resulting in redox-sensitive signaling. In addition, oxLDL diminished the expression of endothelial nitric oxide synthase (eNOS), enhanced the expression of endothelin-1 and adhesion molecules (ICAM, E-selectin, and monocyte chemoattractant protein-1), and increased the adherence of monocytic THP-1 cells to HUVECs. Pretreatment with EGCG, however, exerted significant cytoprotective effects in all events. These data suggest that EGCG inhibits the oxLDL-induced LOX-1-mediated signaling pathway, at least in part, by inhibiting NADPH oxidase and consequent ROS-enhanced LOX-1 expression, which contributes to further ROS generation and the subsequent activation of NF-kappaB via the p38 MAPK pathway. Results from this study may provide insight into a possible molecular mechanism by which EGCG suppresses oxLDL-mediated vascular endothelial dysfunction.
H-reflex modulation during gait in multiple sclerosis patients with spasticity (1995)

The aim of the present study was to quantitate the Hoffmann (H-) reflex modulation in the soleus muscle of spastic multiple sclerosis patients during walking at different stimulus strengths, and to quantitate the influence of the excitation level of the soleus muscle on the H-reflex. The H-reflex modulation was quantified by the minimum H-reflex in the swing phase and the modulation index introduced by Yang et al. (1). Stimulus strengths were matched between subjects, and only stimuli intensities, which reflect modulation in the H-reflex with true neurophysiological origin, were used. Based on this approach, we found that the reflex modulation is impaired in moderate spastic patients at both a strong and a weak afferent input to the motoneuron pool in consistency with studies on severe spastic patients. This study concludes that the H-reflex modulation in the spastic patients is only related to the excitation level of the muscles, whereas both the excitation level and other factors than the excitation level are known to influence the H-reflex modulation in healthy subjects.
Colloidal (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Near-room-temperature tunneling magnetoresistance in a trilayer La0.67Sr0.33MnO3/La0.85Sr0.15MnO3/La0.67Sr0.33MnO3 device (2000)

A trilayer La0.67Sr0.33MnO3/La0.85Sr0.15MnO3/La0.67Sr0.33MnO3 tunneling magnetoresistance (TMR) device has been epitaxially produced on a SrTiO3 substrate. The current–voltage curves show that tunneling process dominates the carrier transfer across the junction near room temperature. However, the tunneling effect becomes weak with decreasing temperature. Magnetoresistance of about 4%–6% has been observed below room temperature. The temperature dependence of TMR appears correlated to both the tunneling effect cross the junction and the spin polarization in La0.67Sr0.33MnO3 layers. The temperature dependence of the TMR effect in this device is different from that of other devices based on colossal magnetoresistance materials.
Electric Properties Tomography (EPT) of the Liver in a Single Breathhold Using SSFP (2012)

MR-based Electric Properties Tomography (EPT) provides a noninvasivemeans to assess electric tissue properties, such as conductivity and permittivity, and provides a framework for an accurate determination of local SAR. Furthermore, it may provide a diagnostic parameterin oncology and cardiology. Recently, simplified EPT reconstructionmethods based on the pure image phase information were introduced.In these studies, spin echo (SE) sequences were employed due to their low susceptibility to B0 variations, or fast field echo (FFE) sequences in concert with B0 mapping were performed. However, these scans are prohibitively long for applications which require breath-holding. In the present study, we have employed a fast balanced SSFP sequence, which has similar properties as SE in terms of B0-independendphase accuracy, but provides increased imaging speed and allows forabdominal imaging in a single breathhold. Phantom experiments and first in vivo conductivity scans in the liver of healthy adults are shown.
ChemInform Abstract: A Practical Synthesis of Rosefuran. Furans from Acetylenes and Allyl Alcohols. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Linear Regression With Gaussian Model Uncertainty: Algorithms and Bounds (2008)

In this paper, we consider the problem of estimating an unknown deterministic parameter vector in a linear regression model with random Gaussian uncertainty in the mixing matrix. We prove that the maximum-likelihood (ML) estimator is a (de)regularized least squares estimator and develop three alternative approaches for finding the regularization parameter that maximizes the likelihood. We analyze the performance using the Cramer-Rao bound (CRB) on the mean squared error, and show that the degradation in performance due the uncertainty is not as severe as may be expected. Next, we address the problem again assuming that the variances of the noise and the elements in the model matrix are unknown and derive the associated CRB and ML estimator. We compare our methods to known results on linear regression in the error in variables (EIV) model. We discuss the similarity between these two competing approaches, and provide a thorough comparison that sheds light on their theoretical and practical differences.
Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin (2014)

Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30-60% but no common genetic contribution has been identified. The CORtisol NETwork (CORNET) consortium undertook genome wide association meta-analysis for plasma cortisol in 12,597 Caucasian participants, replicated in 2,795 participants. The results indicate that <1% of variance in plasma cortisol is accounted for by genetic variation in a single region of chromosome 14. This locus spans SERPINA6, encoding corticosteroid binding globulin (CBG, the major cortisol-binding protein in plasma), and SERPINA1, encoding α1-antitrypsin (which inhibits cleavage of the reactive centre loop that releases cortisol from CBG). Three partially independent signals were identified within the region, represented by common SNPs; detailed biochemical investigation in a nested sub-cohort showed all these SNPs were associated with variation in total cortisol binding activity in plasma, but some variants influenced total CBG concentrations while the top hit (rs12589136) influenced the immunoreactivity of the reactive centre loop of CBG. Exome chip and 1000 Genomes imputation analysis of this locus in the CROATIA-Korcula cohort identified missense mutations in SERPINA6 and SERPINA1 that did not account for the effects of common variants. These findings reveal a novel common genetic source of variation in binding of cortisol by CBG, and reinforce the key role of CBG in determining plasma cortisol levels. In turn this genetic variation may contribute to cortisol-associated degenerative diseases.
Myocardial imaging with Tc-99m EDA-ESM: Safety, biodistribution and dosimetry in animal models (2011)

1534 Objectives Esmolol (ESM) binds to beta-1 receptors in heart tissue and reduces morbidity and mortality in patients with various cardiac diseases. Previously, we reported the cardiac uptake of Tc-99m ethylenediamine-esmolol (EDA-ESM) was via a receptor mediated process (Oh CS, JNM 2010; 51 (supp2):299). The optimal dosage for cardiac uptake of Tc-99m EDA-ESM was 0.2 mg/kg in rats at 30 min by planar imaging. This study was aimed to evaluate safety, biodistribution and dosimetry of Tc-99m EDA-ESM in normal rats. Methods EDA-ESM is synthesized by reacting ESM with EDA followed by purification. For acute toxicity studies, F-344 rats were administered with EDA-ESM. Blood chemistries on day 0, 3 and 14 were measured. Biodistribution of Tc-99m EDA-ESM and 18F-FDG were performed in normal F-344 rats. Rat absorbed doses estimates for Tc-99m EDA-ESM were computed based on their respective biodistribution data. Residence times were then used to calculate target organ absorbed radiation doses for a standard 70 kg male model using the Olinda software package. Results EDA-ESM dosages up to 1.0 mg/rat are well tolerated by rats. The imaging dose at 0.2 mg/kg in rats showed no acute toxicity. The imaging dose in rats per kg is 350 times more than dose proposed in human. In biodistribution, the cardiac uptake (%ID/g) at 30 min for Tc-99m EDA-ESM and 18F-FDG was 1.00±0.12 and 1.43±0.04, respectively. Tc-99m EDA-ESM had poor brain uptake whereas 18F-FDG had high brain uptake. Based upon preclinical studies, radiation exposure to the whole body, blood-forming organs, gonads and effective dose equivalent are far below the limits of the maximum allowed dose. Conclusions Dosimetry data revealed that Tc-99m EDA-ESM is safe for imaging at the dose 0.2 mg/kg (iv) in rats. Tc-99m EDA-ESM SPECT could provide quantitative analysis of cardiac-adrenergic receptor sites for early detection of cardiac disorders
Full orientation control of epitaxial MoS2 on hBN assisted by substrate defects (2019)

Inversion asymmetry in two-dimensional materials grants them fascinating properties such as spin-coupled valley degrees of freedom and piezoelectricity, but at the cost of inversion domain boundaries if the epitaxy of the grown two-dimensional (2D) layer, on a polar substrate, cannot adequately distinguish what are often near-degenerate ${0}^{\ensuremath{\circ}}$ and ${180}^{\ensuremath{\circ}}$ orientations. We employ first-principles calculations to identify a method to lift this near degeneracy: the energetic distinction between eclipsed and staggered configurations during nucleation at a point defect in the substrate. For monolayer ${\mathrm{MoS}}_{2}$ grown on hexagonal boron nitride, the predicted defect complex can be more stable than common ${\mathrm{MoS}}_{2}$ point defects because it is both a donor-acceptor pair and a Frenkel pair shared between adjacent layers of a 2D heterostack. Orientation control is verified in experiments that achieve $\ensuremath{\sim}90%$ consistency in the orientation of as-grown triangular ${\mathrm{MoS}}_{2}$ flakes on hBN, as confirmed by aberration-corrected scanning/transmission electron microscopy. This defect-enhanced orientational epitaxy could provide a general mechanism to break the near-degeneracy of $0/{180}^{\ensuremath{\circ}}$ orientations of polar 2D materials on polar substrates, overcoming a long-standing impediment to scalable synthesis of single-crystal 2D semiconductors.
Revealing the human mucinome (2021)

Abstract Mucin domains are densely O-glycosylated modular protein domains found in a wide variety of cell surface and secreted proteins. Mucin-domain glycoproteins are key players in a host of human diseases, especially cancer, but the scope of the mucinome remains poorly defined. Recently, we characterized a bacterial mucinase, StcE, and demonstrated that an inactive point mutant retains binding selectivity for mucins. In this work, we leveraged inactive StcE to selectively enrich and identify mucins from complex samples like cell lysate and crude ovarian cancer patient ascites fluid. Our enrichment strategy was further aided by an algorithm to assign confidence to mucin-domain glycoprotein identifications. This mucinomics platform facilitated detection of hundreds of glycopeptides from mucin domains and highly overlapping populations of mucin-domain glycoproteins from ovarian cancer patients. Ultimately, we demonstrate our mucinomics approach can reveal key molecular signatures of cancer from in vitro and ex vivo sources.
Creating an Immune-Privileged Site Using Retinal Progenitor Cells and Biodegradable Polymers (2007)

We describe the creation of local immune privilege (IP) using retinal progenitor cells (RPCs) and biodegradable polymers. Murine RPCs were seeded on poly(lactic-coglycolic acid) polymers to generate composite grafts. Composites or RPCs alone were transplanted into allogeneic kidney capsules. Grafts survived at all time points, differentiating into neurons and astrocytes. Upon treatment with interferon gamma (IFNgamma), major histocompatibility complex antigens were upregulated. Although 10% of IFNgamma-treated RPC grafts survived 14 days, 66% of the IFNgamma-treated composites survived in part by producing immune suppressive factors transforming growth factor-beta2, Fas ligand, and indoleamine 2,3-dioxygenase. The composites were assayed for delayed-type hypersensitivity (DTH) by seeding composites with antigen-presenting cells incubated with ovalbumin. This resulted in suppression of ovalbumin-specific DTH, indicating that composite grafts consisting of biodegradable polymers and central nervous system progenitor cells can be used to generate local IP. This technology may be used to promote the survival of nonprivileged grafts (e.g., pancreas, liver, or skin). Disclosure of potential conflicts of interest is found at the end of this article.
Diamond Optomechanical Crystals at Cryogenic Temperatures (2018)

We investigate the properties of optomechanical crystals (OMCs) fabricated in single-crystal diamond in a cryogenic environment (T ~ 5K). We demonstrate high mechanical Q-factors (&gt; 100,000) from localized OMC mechanical modes at 5 &amp; 8 GHz, a 30x improvement from room temperature.
Three-dimensional printing accuracy analysis for medical applications across a wide variety of printers (2023)

These results show how factors such as printing technology, vendor, and printer model can impact 3D printing accuracy, which should be appropriately considered in practice to avoid potential medical or surgical errors.
Frequency Analysis and Fast Fourier Transform (2006)

This chapter contains sections titled: Fourier Series and Transform Discrete Fourier Transform Fast Fourier Transforms Implementation Considerations Practical Applications Experiments and Program Examples References Exercises
Building intrusion tolerant applications (2002)

The ITTC project (Intrusion Tolerance via Threshold Cryptography) provides tools and an infrastructure for building intrusion tolerant applications. Rather than prevent intrusions or detect them after the fact, the ITTC system ensures that the compromise of a few system components does not compromise sensitive security information. To do so we protect cryptographic keys by distributing them across a few servers. The keys are never reconstructed at a single location. Our designs are intended to simplify the integration of ITTC into existing applications. We give examples of embedding ITTC into the Apache web server and into a Certification Authority (CA). Performance measurements on both the modified web server and the modified CA show that the architecture works and performs well.
Rainbow Plasmonic Nanobubbles: Synergistic Activation of Gold Nanoparticle Clusters (2011)

The synergistic physical and biological effects of selective targeting and activation of plasmonic nanoparticles were studied for a transient vapor nanobubble mode. Simultaneous optical activation of two plasmon resonances in multi-nanoparticle clusters significantly improved the selectivity and efficacy of the nanobubble generation through and was termed "rainbow plasmonic nanobubbles." The rainbow nanobubble mechanism has been studied in water and in living cells in vitro. This mechanism provided maximal selectivity of the nanobubble generation in both models and therefore, can the therapeutic selectivity and optical contrast of gold nanoparticles in a heterogeneous physiological microenvironment at cell level.
IPTV Challenges (2008)

The article consists of a PowerPoint presentation and a collection of slides from author's conference presentation on IPTV challenges. The areas discussed include: IPTV End-to-end flow example; characteristics/requirements IPTV imposes on transport network; network architecture; restoration causes of loss in IPTV access networks; R-UDP; forward error control (FEC) and instant channel change.
High-index Resonator Supercavity with Different Background Contrast (2023)

Our detailed study aims to analyze the effect of background contrast on the excitation of supercavity modes in high index resonators (HIR) for microstrip-HIR systems. This goal is achieved by designing a model in the microwave range; a high contrast background permittivity is defined depending on the system geometry and resonant frequency. We show that the Q-factor increases up to 80% of the material quality factor for optimized contrast and background.
Analysis of Interaction between Grouser and Soil Using DEM (Distinct Element Method)(<Special Issue>Dynamics & Design Conference 2009) (2010)

Signing for tracked vehicles that are operated on non-pavement road or soft ground, it is important to analyze the interaction between a machine and soil. In this research, attention was focused on the interaction under front-idler, that is, traction soil by a grouser in driving system. To verify the validity of interaction analysis between a grouser and soil by using 3-dimensional DEM soil model, traction simulations and experiments were carried out. In addition, the soil model was considered particle roughness to introduce compaction effect by compression. To check the effectiveness of the soil model, compression test and shearing test were conducted. Consequently, soil behavior and porosity change were found on the tests. And comparing the results of traction simulations and experiments, soil behavior and qualitative characteristics of traction resistance were conformed. Therefore, interaction between grouser and soil cloud be analyzed by using the soil model considered particle roughness.
Embedding edit distance to enable private keyword search (2012)

Our work is focused on fuzzy keyword search over encrypted data in Cloud Computing. We adapt results on private identification schemes by Bringer et al. to this new context. We here exploit a classical embedding of the edit distance into the Hamming distance. Our way of doing enables some flexibility on the tolerated edit distance when looking for close keywords while preserving the confidentiality of the queries. Our proposal is proved secure in a security model taking into account privacy.
Palladium Nanoparticles Stabilized on PEG‐Modified Silica as Catalysts for the Aerobic Alcohol Oxidation in Supercritical Carbon Dioxide. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ultrashort pulse generation from mode-locked erbium-doped fibre ring lasers (1999)

Abstract A theoretical model of a passively mode-locked erbium-doped fibre ring laser using nonlinear polarization rotation is developed. Numerical simulations are used to study mode-locking and pulse dynamics in a typical ring configuration. The simulations show that stable operation can exist in both isotropic and birefringent fibres, and stable pulses with a FWHM as short as 45 fs can be generated. It is found that there is an optimal regime of ellipticity such that the stable mode-locking can be obtained. In addition, the condition for high birefringence approximation is also found.
sfinx: an R package for the elimination of false positives from affinity purification–mass spectrometry datasets (2017)

Supplementary data are available at Bioinformatics online.