gebhart/patrepeval huggingface dataset:
853: Bone Scan in Assessing Biochemical Failure After Radical Prostatectomy – Efficacy and Risk Factors for a Positive Scan (2004)

You have accessJournal of UrologyDiscussed Poster, Monday, May 10, 2004, 8:00 am - 12:00 pm1 Apr 2004853: Bone Scan in Assessing Biochemical Failure After Radical Prostatectomy – Efficacy and Risk Factors for a Positive Scan Zohar A. Dotan, Fernando J. Bianco, Paul A. Fearn, Hui-Ni Chen, James A. Eastham, Farhang Rabbani, Steven C. Eberhardt, Hedvig Hricak, Peter T. Scardino, and Michael W. Kattan Zohar A. DotanZohar A. Dotan , Fernando J. BiancoFernando J. Bianco , Paul A. FearnPaul A. Fearn , Hui-Ni ChenHui-Ni Chen , James A. EasthamJames A. Eastham , Farhang RabbaniFarhang Rabbani , Steven C. EberhardtSteven C. Eberhardt , Hedvig HricakHedvig Hricak , Peter T. ScardinoPeter T. Scardino , and Michael W. KattanMichael W. Kattan View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)38102-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "853: Bone Scan in Assessing Biochemical Failure After Radical Prostatectomy – Efficacy and Risk Factors for a Positive Scan." The Journal of Urology, 171(4S), pp. 225–226 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 225-226 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Zohar A. Dotan More articles by this author Fernando J. Bianco More articles by this author Paul A. Fearn More articles by this author Hui-Ni Chen More articles by this author James A. Eastham More articles by this author Farhang Rabbani More articles by this author Steven C. Eberhardt More articles by this author Hedvig Hricak More articles by this author Peter T. Scardino More articles by this author Michael W. Kattan More articles by this author Expand All Advertisement PDF downloadLoading ...
Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors (2022)

Despite the clinical efficacy of epidermal growth factor receptor (EGFR) inhibitors, a subset of patients with non-small cell lung cancer displays insertion mutations in exon20 in EGFR and Her2 with limited treatment options. Here, we present the development and characterization of the novel covalent inhibitors LDC8201 and LDC0496 based on a 1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine scaffold. They exhibited intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations as well as selectivity over wild type EGFR and within the kinome. Complex crystal structures with the inhibitors and biochemical and cellular on-target activity document their favorable binding characteristics. Ultimately, we observed tumor shrinkage in mice engrafted with patient-derived EGFR-H773_V774insNPH mutant cells during treatment with LDC8201. Together, these results highlight the potential of covalent pyrrolopyridines as inhibitors to target exon20 insertion mutations.
Chiral Aggregates of Triphenylamine‐Based Dyes for Depleting the Production of Hydrogen Peroxide in the Photochemical Water‐Splitting Process (2019)

Abstract Recent studies on water‐splitting photoelectrochemical cells (PECs) have demonstrated the intriguing possibility of controlling the spin state in this chemical reaction to form H 2 and O 2 by exploiting the chirality of organic π ‐conjugated supramolecular polymers. Although this fascinating phenomenon has been disclosed, the chiral supramolecular materials reported thus far are not optimized for acting as efficient photosensitizer for dye‐sensitized PECs. In this work we report on the design, synthesis, and characterization of chiral supramolecular aggregates based on C 3 ‐symmetric triphenylamine‐based dyes that are able to both absorb visible light and control the spin state of the process. Variable temperature‐dependent spectroscopic measurements reveal the assembly process of the dyes and confirm the formation of chiral aggregates, both in solution as well as on solid supports. Photoelectrochemical measurements on TiO 2 ‐based anodes validate the advantage of using chiral supramolecular aggregates as photosensitizer displaying higher photocurrent compared to achiral analogues. Moreover, fluorimetric tests for the quantification of the hydrogen peroxide produced, confirm the possibility of controlling the spin of the reaction exerting spin‐selection with chiral supramolecular polymers. These results represent a further step towards the next‐generation of organic‐based water‐splitting solar cells.
Multi-shaping technique reduces sidelobe magnitude in optical coherence tomography (2017)

Shaping methods that are commonly used in Fourier-domain optical coherence tomography (FD-OCT) can suppress sidelobe artifacts in the axial direction, but they typically broaden the mainlobe of the point spread function (PSF) and reduce the axial resolution. To improve OCT image quality without this tradeoff, we have developed a multi-shaping technique that reduces the axial sidelobe magnitude dramatically and achieves better axial resolution than conventional shaping methods. This technique is robust and compatible in various FD-OCT imaging systems. Testing of multi-shaping in three experimental settings shows that it reduced the axial sidelobe contribution by more than 8 dB and improved the contrast to noise by at least 30% and up to three-fold. Multi-shaping enables accurate image analysis and is potentially useful in many OCT applications.
Analisi delle micro-reti in corrente continua in bassa tensione (2014)

L’articolo illustra l’analisi del comportamento del sistema in assenza ed in presenza di guasto, in relazione alle modalità di collegamento delle parti&#13;\nattive e delle masse rispetto a terra.
Tensor Networks and Quantum Error Correction (2014)

We establish several relations between quantum error correction (QEC) and tensor network (TN) methods of quantum many-body physics. We exhibit correspondences between well-known families of QEC codes and TNs, and demonstrate a formal equivalence between decoding a QEC code and contracting a TN. We build on this equivalence to propose a new family of quantum codes and decoding algorithms that generalize and improve upon quantum polar codes and successive cancellation decoding in a natural way.
Biphasic Aerobic Oxidation of Alcohols Catalyzed by Poly(ethylene glycol)‐Stabilized Palladium Nanoparticles in Supercritical Carbon Dioxide (2005)

Active, selective, and stable: The combination of poly(ethylene glycol) (PEG) as a catalyst phase and supercritical carbon dioxide (scCO2) as a mobile phase provides a “green” approach to the continuous-flow aerobic oxidation of primary and secondary alcohols by catalytically active palladium nanoparticles (see scheme). The activity of the system even slightly increases with reaction time, because CO2 appears to improve the dispersion of the Pd particles in the PEG matrix.
Sensitization mechanisms from excited‐singlet state of pyrromethene dye to a radical‐generating reagent in a poly(methylmethacrylate) film (1999)

The sensitization mechanisms of a pyrromethene dye with a radical-generating reagent, 3,5,3′,5′-tetramethylpyrromethene-BF2 (BH) with 3,3′,4,4′-tetrakis(t-butyldioxycarbonyl)benzophenone (BP), in a poly- (methylmethacrylate) (PMMA) film were investigated by laser flash phoptolysis using a total reflection cell and single photon counting. From the laser flash photolysis, strong fluorescence was detected though no transient absorption was detected. The fluorescence intensity was significantly decreased with increasing concentration of BP, apparently exhibiting Perrin-type static quenching at a quenching radius, Rf = 26 Å. From the examination of decay profile using single photon counting, logarithmic plots of fluorescence decay in a PMMA film afforded a nonlinear, convex reduction, corresponding to a streched exponential decay, while the logarithmic plots in acetonitrile showed a linear relationship. With increasing concentration of BH, the fluorescence maximum was shifted to red, and the intensity of fluorescence was significantly reduced. The red shift of fluorescence, the nonlinear fluorescence logarithmic decay and the large reduction in fluorescence indicate a dispersive photoexcited state and a relaxation of excitation energy hopping across an array of sites with Gaussian energy distribution. Moreover, after incorporating BP, the convex logarithmic plots became more steep, and the fluorescence maximum was also shifted to red, exhibiting a nonstatic quenching process competitive to the excitation energy hopping. Thus the sensitization of photoinitiator system containing BH and BP, whose contents were almost same as that in the commercial products, was due to a static quenching process from dispersive singlet excited BH to BP ground state, and the nonstatic quenching process competitive to the excitation energy hopping was minimal. Copyright © 1999 John Wiley & Sons, Ltd.
Long-term follow-up of patients with chronic hepatitis C treated with different doses of interferon-alpha 2b. (1993)

Eighty patients with chronic hepatitis C who completed a previously reported randomized controlled trial on the efficacy of interferon-alpha 2b were followed up for at least 36 mo after therapy discontinuation. Seventeen patients (21.2%) maintained normal ALT values throughout the follow-up; 63 (78.8%) either did not normalize the levels of ALT or relapsed during the follow-up. A significantly greater proportion of patients treated with 3 million units of interferon three times a week subcutaneously for 48 wk were long-term responders compared with patients treated for 24 wk. Sex, age, hepatitis C virus antibody status, source of infection and pretreatment levels of ALT were not predictive of long-term response. Cirrhosis was found to be an unfavorable predictive factor. After 3 yr of follow-up, clearance of viremia was observed in 58.9% of the 17 long-term responders but in none of the non-responders (p = 0.002). E2-NS1 antibody tested negative in 88.2% of long-term responders and in 14.3% of nonresponders (p = 0.001). Fifty-nine percent of long-term responders tested negative for C100-NS4 antibody compared with 14.3% of nonresponders (p = 0.031). No significant change was observed in other antibodies. Four long-term responders underwent liver biopsy 2 yr after discontinuation of therapy. All four patients had normal liver histology compared with baseline assessment of chronic active hepatitis in three and chronic persistent hepatitis in the other. Three of the four were negative for serum hepatitis C virus RNA.
Measurement of Short-Wave Modulation Using Fine Time-Series Optical Spectra (1981)

Abstract Photographic imagery of the ocean surface can be either optically or digitally Fourier-transformed to obtain ocean slope spectra (Monaldo and Kasevich, 1981; Stilwell, 1969). Here we outline a straightforward method of using time-series ocean photographs to determine the modulation of short-wave energy spectra by long surface waves. Specific attention is given to the isolation of actual spectral modulation of the ocean surface from spurious modulation introduced by the imaging process.
A self-learning neural-network LSI using neuron MOSFETs (2003)

A functional MOS transistor called a neuron MOSFET (vMOS) which simulates the function of biological neurons is discussed. A method of constructing neural network LSIs that have a self-learning capability using the neuron MOSFET is given. The key is the implementation of a synaptic connection which changes its weight according to various learning algorithms. In addition, the synapse must be free from standby power dissipation and be as small as possible.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Cavity-enhanced single artificial atoms in silicon (2023)

Artificial atoms in solids are leading candidates for quantum networks, scalable quantum computing, and sensing, as they combine long-lived spins with mobile and robust photonic qubits. The central requirements for the spin-photon interface at the heart of these systems are long spin coherence times and efficient spin-photon coupling at telecommunication wavelengths. Artificial atoms in silicon have a unique potential to combine the long coherence times of spins in silicon with telecommunication wavelength photons in the world's most advanced microelectronics and photonics platform. However, a current bottleneck is the naturally weak emission rate of artificial atoms. An open challenge is to enhance this interaction via coupling to an optical cavity. Here, we demonstrate cavity-enhanced single artificial atoms at telecommunication wavelengths in silicon. We optimize photonic crystal cavities via inverse design and show controllable cavity-coupling of single G-centers in the telecommunications O-band. Our results illustrate the potential to achieve a deterministic spin-photon interface in silicon at telecommunication wavelengths, paving the way for scalable quantum information processing.
Low internal loss separate confinement heterostructure InGaAs/InGaAsP quantum well laser (1987)

The structure and properties of a high performance InGaAs/InGaAsP separate confinement heterostructure multiple quantum well laser operating at 1.54 μm are described. The laser has low threshold current (18 mA), high quantum efficiency (22% facet), high cw output power (42 mW/facet), and weak dependence of the threshold currents and efficiencies on cavity length.
Advanced Gate Technologies for State-of-the-art f[subscript T] in AlGaN/GaN HEMTs (2010)

In this paper, the lower-than-expected frequency performance observed in many AlGaN/GaN high electron mobility transistors (HEMTs) has been attributed to a significant drop of the intrinsic small-signal transconductance (g[subscript m]) with respect to the intrinsic DC g[subscript m]. To reduce this gm-collapse and improve high frequency performance, we have developed a new technology based on a combination of vertical gate-recess, oxygen plasma treatment, and lateral gate-etch which has allowed us to fabricate AlGaN/GaN HEMTs with a record current-gain cutoff frequency (f[subscript T]) of 225 GHz for a gate length (L[subscript g]) of 55 nm, and 162 GHz for an L[subscript g] of 110 nm.
Automated Identification and Deconstruction of Penalty Clauses in Regulation (2021)

Regulations are often complex and therefore difficult to understand. Violations are known to occur oftentimes because of this lack of understanding. Regulations contain penalty clauses that impose some kind of punitive measures on the defaulting party in case of non-compliance. In this paper, we present a model for extracting and deconstructing penalty clauses. The model allows for capturing the essence of penalty clauses in terms of their critical attributes such as Trigger, Consequent Action, Penalized Entity, Subsequent Offence and Exception. We augment the extracted penalty attributes with relevant Definitions and render the deconstructed and augmented penalty clauses for a better understandability. We discuss the results of automating the identification and deconstruction of penalty clauses using a combination of rule-based techniques and Recurrent Neural Network based sequence-to-sequence model designed around the Penalty Model. The evaluation carried out on 39 publicly available regulation documents from sixteen countries indicate that our method can identify penalty clauses with a F1-score of 95% and extract 85% of the attribute instances correctly. This will help the requirement analysts to identify critical software requirements implied in penalty clauses, prioritize them, and thereby contribute to building compliant software systems.
Impact of Spatial Correlation and Precoding Design in OSTBC MIMO Systems (2010)

\boldmath The impact of transmission design and spatial correlation on the symbol error rate (SER) is analyzed for multi-antenna communication links. The receiver has perfect channel state information (CSI), while the transmitter has either statistical or no CSI. The transmission is based on orthogonal space-time block codes (OSTBCs) and linear precoding. The precoding strategy that minimizes the worst-case SER is derived for the case when the transmitter has no CSI. Based on this strategy, the intuitive result that spatial correlation degrades the SER performance is proved mathematically. In the case when the transmitter knows the channel statistics, the correlation matrix is assumed to be jointly-correlated (a generalization of the Kronecker model). The eigenvectors of the SER-optimal precoding matrix are shown to originate from the correlation matrix and the remaining power allocation is a convex problem. Equal power allocation is SER-optimal at high SNR. Beamforming is SER-optimal at low SNR, or for increasing constellation sizes, and its optimality range is characterized. A heuristic low-complexity power allocation is proposed and evaluated numerically. Finally, it is proved analytically that receive-side correlation always degrades the SER. Transmit-side correlation will however improve the SER at low to medium SNR, while its impact is negligible at high SNR.
Wavefunction Mapping of Immobilized InP Semiconductor Nanocrystals (2009)

On the map: The electronic structure of InP nanocrystals (NCs) is studied and the symmetry of the squared wavefunctions (WFs) corresponding to the confined states in the spectral density is mapped directly (see picture). The WF maps show s- and p-type character and charging energies that decrease when higher orbitals are occupied. Coupling of the NCs with the environment influences the WF energies and symmetries.
<title>Polarization diversity active imaging</title> (1997)

Polarization diversity active imaging is a new active imaging technique which illuminates a scene or target with a sequence of polarization states and then measures images of the polarization state scattered from a scene. These polarization images are then analyzed to determine the polarization characteristics at each pixel by measuring the Mueller matrix image, then mapping the retardance, diattenuation, and depolarization images over the scene. These data sets are used to estimate the plane of incidence and target orientation pixel by pixel.
Onchocerca volvulus: in vitro cytotoxic effects of human neutrophils and serum on third-stage larvae. (1994)

The cytotoxic effects of neutrophils co-cultured with infective third-stage larvae (L3) and autologous serum from three groups of individuals: infected (INF), non-patent endemic normals (EN) and non-endemic controls (NEC), were compared using a MTT (3-(4,5 dimethylthiazol-2yl)-2,5 diphenyl tetrazolium bromide) reduction assay as a biochemical parameter of larval viability. The MTT assay permitted the detection of L3 which had suffered varying levels of necrosis. The observations from this study indicate that infected individuals and endemic normals are capable of mounting a specific immune response against the infective L3. This is based on our findings of i) significantly greater numbers of L3 showed necrosis in neutrophil cultures of the INF and EN compared to those from the NEC, ii) a superior ability of cultures from these individuals to inhibit the molting of L3 to fourth-stage larvae, iii) IgG antibodies reactive with the surface of L3, detected by immunofluorescence in the serum of the INF and the EN and iv) recognition of specific antigens in extracts of L3 detected by Western blot analysis. The specific immune response directed against L3 is probably a significant immunological defense mechanism used to limit infection in endemic areas.
sidewalls modification of porous SiOCH material induced by reducing and oxidizing post etching plasma treatments (2009)

International audience
16 Posttranscriptional Regulation of Heat Shock Protein Synthesis in Drosophila (1990)

I. INTRODUCTION All cells respond to temperatures above their normal growth temperatures by inducing the synthesis of a small group of evolutionarily conserved polypeptides known as the heat shock proteins (hsps). Some of the hsps are required to help cells grow at the upper end of their normal temperature range, others to help cells withstand the toxic effects of more extreme temperatures. Many of the proteins are also produced at normal temperatures or have close relatives that are produced at normal temperatures (the “heat shock cognate” proteins). The hsps and their relatives participate in an extraordinary variety of cellular processes, including DNA synthesis, protein secretion, the response to steroid hormones, and the “chaperoning” of newly synthesized proteins. The variety and complexity of these interactions are only beginning to be unraveled. What defines the hsps as a group, however, is the immediate and very dramatic increase in their synthesis when cells are exposed to higher temperatures (Lindquist and Craig 1988). Considering the extremely ancient nature of the heat shock response and the extraordinary variety of organisms and cell types in which it is found, it is not surprising that several different mechanisms have evolved to ensure that the hsps will be produced as rapidly as possible after a shift to high temperature. In all organisms investigated, transcriptional regulation plays an important role in the induction of the hsps. In eukaryotes, a heat-shock-activated transcription factor binds to a promoter/enhancer element that provides heat-inducible transcription (for review, see Chapters 17 and 18). In...
Reduction of Uranium(VI) Phosphate during Growth of the Thermophilic Bacterium Thermoterrabacterium ferrireducens (2005)

The thermophilic, gram-positive bacterium Thermoterrabacterium ferrireducens coupled organotrophic growth to the reduction of sparingly soluble U(VI) phosphate. X-ray powder diffraction and X-ray absorption spectroscopy analysis identified the electron acceptor in a defined medium as U(VI) phosphate [uramphite; (NH4)(UO2)(PO4) . 3H2O], while the U(IV)-containing precipitate formed during bacterial growth was identified as ningyoite [CaU(PO4)2 . H2O]. This is the first report of microbial reduction of a largely insoluble U(VI) compound.
Structures of Three HIV-1 HLA-B*5703-Peptide Complexes and Identification of Related HLAs Potentially Associated with Long-Term Nonprogression (2005)

Long-term nonprogression during acute HIV infection has been strongly associated with HLA-B*5701 or HLA-B*5703. In this study, we present the high resolution crystal structures of HLA-B*5703 complexes with three HIV-1 epitopes: ISPRTLNAW (ISP), KAFSPEVIPMF (KAF-11), and KAFSPEVI (KAF-8). These reveal peptide anchoring at position 2 and their C termini. The different peptide lengths and primary sequences are accommodated by variation in the specific contacts made to the HLA-B*5703, flexibility in water structure, and conformational adjustment of side chains within the peptide-binding groove. The peptides adopt markedly different conformations, and trap variable numbers of water molecules, near a cluster of tyrosine side chains located in the central region of the peptide-binding groove. The KAF-11 epitope completely encompasses the shorter KAF-8 epitope but the peptides are presented in different conformations; the KAF-11 peptide arches out of the peptide-binding groove, exposing a significant main chain surface area. Bioinformatic analysis of the MHC side chains observed to contribute to the peptide anchor specificity, and other specific peptide contacts, reveals HLA alleles associated with long-term nonprogression and a number of related HLA alleles that may share overlapping peptide repertoires with HLA-B*5703 and thus may display a similar capacity for efficient immune control of HIV-1 infection.