gebhart/patrepeval huggingface dataset:
Optically Seamless Flexible Electronic Tiles for Ultra Large-Area Digital X-Ray Imaging (2014)

This paper presents a new flexible electronics assembly technique that combines individual digital X-ray detectors to create a much larger composite digital X-ray detector. The new assembly technique uses multiple flexible digital X-ray detectors manufactured on a thin, transparent, and flexible plastic substrate, which are overlapped to create the larger composite X-ray detector. The assembly technique, illustrated in a mechanical mockup, is optically seamless, and has the ability to scale up to extremely large X-ray imaging arrays. Feasibility and preliminary imaging performance were demonstrated by tiling several 16 × 16 pixel resolution prototype flexible X-ray detector test structures. Optical losses under typical digital radiography conditions were also measured by overlapping a plastic substrate flexible X-ray detector onto a commercial glass substrate digital X-ray imaging array. Approximately 5% signal loss was observed in the transparent plastic overlap region, and the seam edge imaging artifact was demonstrated to be correctable using commercial gain calibration. A key medical imaging application for this technology is single-exposure, low-dose, and full-body digital radiography.
Ninety-Day Reimbursements for Primary Single-Level Posterior Lumbar Interbody Fusion From Commercial and Medicare Data (2017)

3.
Volume sculpting based on geometric tools (2009)

The analysis of volumetric datasets is the main concern in many areas ranging from geophysics to biomedical sciences. The direct visualization of these data plays an important role in this scenario, and in spite of developments in volume visualization techniques, interacting with large datasets still demands research efforts due to perceptual and performance issues. There is a need of interactive sculpting tools which can provide an intuitive way to examine and explore inner parts of the datasets, as well as to fill missing data for specific purposes. In this paper we report the development of interactive, intuitive and easy-to-use sculpting tools, which specify regions within the volume to be discarded from rendering, thus allowing inspection of the volume interior, and to be filled with material to build virtual structures in the volume. Interactive rates for these sculpting tools were obtained by running special fragment programs on the graphics hardware. The tools were implemented using two interaction metaphors (virtual pointer and virtual hand) and following different approaches in terms of devices and single versus two-handed interaction. We report the evaluation of these approaches in detail and concluded that the use of two different devices together presents a better performance and are preferred by users. Moreover, the use of virtual hand interaction provided better results than using the virtual pointer during the tests.
Simulations of measured photobleaching kinetics in human basal cell carcinomas suggest blood flow reductions during ALA‐PDT (2009)

A detailed numerical study using a comprehensive PDT dosimetry model is consistent with the hypothesis that the observed trends in the in vivo PpIX photobleaching data from patients may be explained on the basis of therapy-induced blood flow reductions at specific fluences.
Abstract 1806: Modulation of natural killer cell immune response to tumor with novel synthetic tumor -immune cell agonist, NK-TICA(r) (2023)

Abstract The tumor specific activation of natural killer (NK) cells with Bicycles is an area of active investigation in immune oncology. NK cells are highly responsive immune cells that can detect and eliminate tumor cells and bridge innate to adaptive immune responses. Bicycles are small (ca.1.5kDa), chemically synthetic, structurally constrained peptides discovered via phage display and optimized using structure-driven design and medicinal chemistry approaches. We have applied the Bicycle platform technology to discover and evaluate a new class of fully synthetic molecules termed NK tumor immune cell agonists (NK-TICA®). The NK-TICA® consists of chemically coupled Bicycles® that bind specifically to the key activating receptor, NKp46, and to tumor antigens, that results in highly potent, antigen-dependent receptor activation and NK cell activation. We demonstrate potent, selective binding of our Bicycles to receptor-expressing cells and the capability of the bifunctional molecule to induce NK cell function in vitro. With Bicycle’s novel NK-TICA® compound, we demonstrate the engagement of NK cells, the specific activation and function of NK cells, and enhanced tumor cytotoxicity in a tumor target- and dose-dependent manner. In conclusion, NK-TICAs drive NK cell-mediated tumor cell killing and cytokine production in vitro and as such have the potential to catalyze the development of durable anti-tumor immunity in tumor types not well served by current therapies. We hypothesize that utilization of Bicycle NK-TICA® as a multifunctional immune cell engager will promote the modulation of NK cells, as well as the infiltration and anti-tumor activity of NK cells in solid tumors. Citation Format: Fay Dufort, Christopher J. Leitheiser, Kathleen Ho, Tucker Ezell, Alexandra Rezvaya, Peter Brown, Liuhong Chen, Philip Brandish, Kevin McDonnell, Michael Skynner, Nicholas Keen. Modulation of natural killer cell immune response to tumor with novel synthetic tumor -immune cell agonist, NK-TICA(r) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1806.
ChemInform Abstract: Synthesis of a New Fluorogenic Substrate for the Continuous Assay of Mammalian Phosphoinositide‐Specific Phospholipase C. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Wire textured, multi-crystalline Si solar cells created using self-assembled masks (2010)

We have developed an inexpensive and scalable method to create wire textures on multi-crystalline Si solar cell surfaces for enhanced light trapping. The wires are created by reactive ion etching, using a monolayer high self-assembled array of polymer microspheres as an etch mask. Chemical functionalization of the microspheres and the Si surface allows the mask to be assembled by simple dispensing, without spin or squeegee based techniques. Surface reflectivities of the resulting wire textured multi-crystalline solar cells were comparable to that of KOH etched single crystal Si (100). Electrically, the solar cells exhibited a 20% gain in the short circuit current compared to planar multicrystalline Si control devices, and a relative increase of 7-16% in the "pseudo" efficiencies when the series resistance contributions are extracted out.
MEMS lubrication with alcohol vapour (2010)

AbstractThe advancement of microelectromechanical systems (MEMS) could enable numerous advanced mechanical and communication technologies. At present, commercial MEMS devices are limited to the ones that have no motion or limited motion without sliding contacts such as linear sliding, hinge motions, rotations, etc. The main limiting factors impeding the inclusion of the full range of mechanical motions are tribological issues associated with adhesion, friction and wear of the devices. To resolve these issues, various types of lubricants and coatings have been developed and applied to MEMS. But the coating approaches have not yet satisfied long term operation requirements necessary for MEMS devices with sliding contacts to be commercially viable. In this review, we introduce a new paradigm in MEMS lubrication: vapour phase lubrication (VPL) with alcohols under equilibrium conditions. Fundamental aspects of alcohol adsorption on silicon oxide surfaces in ambient conditions are addressed and their implications in the reduction of adhesion, friction and more importantly, the prevention of wear, are presented.Keywords: MEMSALCOHOLVAPOUR PHASE LUBRICATION
Three-dimensional carbon-conductive polymer–silver composite air electrodes for non-aqueous metal air batteries (2013)

A novel three-component composite electrode consisting of a carbon current collector with conductive polymer and silver coating is described here. The composite electrode fabrication strategy is described and the composite electrode is evaluated as a cathode for oxygen reduction in non-aqueous media. This approach is utilized for the first time to prepare three-dimensionally structured carbon–conductive polymer–silver composites, yielding composite electrodes with ∼4× the oxygen reduction capacity of their planar counterparts. Improvement of cathode oxygen reduction activity will increase current capability and power output of metal air batteries, facilitating future development of small, lightweight, and long-life power sources.
Filtered Jitter (2000)

Jitter is one popular way of generating samples for stochastic sampling in computer graphics. The Poisson disk distribution better approximates that of the human photomosaic. In this paper we examine the spatial and frequency space behaviour of a number of existing algorithms for generating stochastic samples and propose a new algorithm based on low pass filtering a jittered set of displacements. The distribution is at least as much like that of the human photomosaic as any existing algorithm, while being fast to compute.
Synergistic Enhancement of the Efficacy of the Bioreductively Activated Alkylating Agent RSU-1164 in the Treatment of Prostatic Cancer by Photodynamic Therapy (1989)

Bioreductively activated alkylating agents (BAA) require metabolic reduction to become cytotoxic. Hypoxia induces a massive increase in reductive metabolism activating BAA to their cytotoxic form. One of these BAA agents is cis-2,3-dimethyl 1-(2-nitro-1-imidazolyl)-3-(1-aziridinyl)-2-propanol referred to as RSU-1164. In a hypoxic environment, RSU-1164 is activated to a highly reactive bifunctional alkylating agent capable of crosslinking macromolecules which results in cell death. Photodynamic therapy (PDT) is a treatment modality which consists of the initial accumulation of hematoporphyrin derivative (HPD) within a tumor followed by the activation of the HPD by 630 nm. light to induce a cytotoxic response. The precise mechanism of PDT is not known, however, two actions of the activated HPD have been documented. The first is a direct cytotoxic effect, secondary to singlet oxygen production. The second is through vascular collapse and subsequent hypoxia. The combination of a chemotherapeutic agent like RSU-1164, which is activated by hypoxia, with PDT to produce such hypoxia, therefore, should greatly increase the efficiency and utility of RSU-1164. To test this hypothesis, Copenhagen rats bearing established Dunning R-3327 AT-2 prostate cancers were treated with PDT treatment alone (HPD 20 mg./kg. injected IP and then 24 hr. later, the tumor exposed to 630 nm. light at 400 mW/cm.2 for 30 min. [total dose 720 J/cm.2]), RSU-1164 alone (injected IP at a dose of 200 mg./kg.) or with the combination of this PDT treatment plus RSU-1164 given 30 min. before light exposure. These results demonstrated that this combinational treatment synergistically produces a greater retardation in the growth of the AT-2 tumor than either of the monotherapies of RSU-1164 or PDT alone.
Electrical Excitation of Surface Plasmons (2012)

We show that low energy tunneling electrons can excite propagating surface plasmons in gold nanowires. The separation of excitation and outcoupling proves that the tunneling electrons excite gap plasmons that subsequently couple to propagating plasmons.
Thermal engineering of non-local resistance in lateral spin valves (2014)

We study the non-local spin transport in Permalloy/Cu lateral spin valves (LSVs) fabricated on thermally oxidized Si and MgO substrates. While these LSVs show the same magnitude of spin signals, significant substrate dependence of the baseline resistance was observed. The baseline resistance shows much weaker dependence on the inter-electrode distance than that of the spin transport observed in the Cu wires. A simple analysis of voltage-current characteristics in the baseline resistance indicates the observed result can be explained by a combination of the Peltier and Seebeck effects at the injector and detector junctions, suggesting the usage of high thermal conductivity substrate (or under-layer) is effective to reduce the baseline resistance.
Oscillations in USA COVID-19 Incidence and Mortality Data reflect societal factors (2020)

The COVID-19 pandemic currently in process differs from other infectious disease calamities that have previously plagued humanity in the vast amount of information that is produces each day, which includes daily estimates of the disease incidence and mortality data. Apart from providing actionable information to public health authorities on the trend of the pandemic, the daily incidence reflects the process of disease in a susceptible population and thus reflects the pathogenesis of COVID-19, the public health response and diagnosis and reporting. Both daily new cases and daily mortality data in the US exhibit periodic oscillatory patterns. By analyzing NYC and LA testing data, we demonstrate that this oscillation in the number of cases can be strongly explained by the daily variation in testing. This seems to rule out alternative hypotheses such as increased infections on certain days of the week as driving this oscillation. Similarly, we show that the apparent oscillation in mortality in the US data is mostly an artifact of reporting, which disappears in datasets that record death by episode date, such as the NYC and LA datasets. Periodic oscillations in COVID-19 incidence and mortality data reflect testing and reporting practices and contingencies. Thus, these contingencies should be considered first prior to suggesting social or biological mechanisms.
QBB: Quantile-Based Binarization of 3D Point Cloud Descriptors (2022)

Local 3D point feature descriptors play an important role in many areas of computer vision, such as object recognition, registration, etc. There are many well-functioning feature descriptors, but they are typically real-valued and multidimensional vectors, leading to high computational complexity in nearest neighbor searches. To overcome this challenge, methods binarizing real-valued descriptors have emerged. In this paper, we first investigate the available binarization methods and standalone binary feature descriptors and show that existing binarization techniques cannot generally achieve good performance for arbitrary feature descriptors. To remedy this problem, we propose a new binarization method called quantile-based binarization (QBB) that can be applied to any real-valued feature descriptors. It analyses the distribution of feature descriptors that is then used to form meaningful groups along each dimension. To this end, QBB computes quantiles of the empirical distribution and the interval lengths (bin sizes) defined by quantile boundaries. Finally, it assigns a binary code to each group and concatenate them to get the final binary descriptor. QBB is able to adaptively compute the number of bits based on a capacity constraint, i.e., with the appropriate capacity setting, the resulting binary descriptor can be used on devices with lower computational power. We evaluate the descriptiveness of well-known descriptors binarized by QBB and compare them to state-of-the-art methods. According to our evaluation, QBB is able to create binary descriptors whose descriptiveness is closer to the real-valued descriptors than prior approaches. Finally, we also show that QBB can even compete with standalone binary feature descriptors.
Selective 1D1H →13C →13C polarization transfer experiments for small organic molecules (1999)

Selective polarization transfer from proton to adjacent carbon was accomplished by either selective cross-polarization or selective refocused-INEPT. Magnetization was transferred in the subsequent step to remote carbons separated by one, two or three bonds. The acquired data were processed by a new symmetrization protocol resulting in the signal-to-noise ratio enhancement by a factor of √2. Copyright © 1999 John Wiley & Sons, Ltd.
Experimental study on thermal performance of loop heat pipes with flat evaporator for LSI package (2012)

Thermal performance of a loop heat pipe (LHP) equipped with a flat evaporator and a compensation chamber integrated onto the evaporator and separated from the evaporator was experimentally investigated. The heat leak in the flat evaporator is a critical problem as it results in the degradation of the heat transport characteristics of the LHP. In this paper, the heat leak quantity during the steady-state operation of the LHP was calculated by carrying out a thermal energy balance analysis for the flat evaporator. From the results, the heat conduction along the case sidewall of the evaporator dominated the heat leak on the evaporator, and it was found that the heat leak from the heat source to the compensation chamber decreased to 5% or less of the applied input power due to the reduced heat conduction of the evaporator casing.
Structure-Based Design of Tet Repressor To Optimize a New Inducer Specificity (2004)

We constructed a mutant of the tetracycline-inducible repressor protein TetR with specificity for the tc analogue 4-de(dimethylamino)anhydrotetracycline (4-ddma-atc), which is neither an antibiotic nor an inducer for the wild-type protein. The previously published relaxed specificity mutant TetR H64K S135L displays reduced induction by tc but full induction by doxycycline (dox), anhydrotetracycline (atc), and 4-de(dimethylamino)-6-demethyl-6-deoxytetracycline (cmt3). To create induction specificity for tc derivatives lacking the 4-dimethylamino grouping such as cmt3 and 4-ddma-atc, the residues at positions 82 and 138, which are located close to that moiety in the crystal structure of the TetR-[tc-Mg](+)(2) complex, were randomized. We anticipated that a residue with increased size may lead to sterical hindrance, and screening for 4-ddma-atc-specific induction indeed revealed the mutant TetR H64K S135L S138I. Out of 24 exchanges only the addition of S138I to TetR H64K S135L yielded a mutant with a pronounced reduction of affinity for atc and dox, while the one for 4-ddma-atc is not affected. The ratio of binding constants revealed a 200-fold specificity increase for 4-ddma-atc over atc. The contributions of each single mutant to specificity indicate that the tc variants bind slightly different positions in the TetR tc binding pocket.
Formation of conjugated polyene and polyyne structure by KrF excimer laser-induced dehydrochlorination on polyvinylidenechloride film (1998)

The surface dehydrochlorination of poly(vinyldenchloride) film was performed to produce a conjugated polyyne and polyene structures by photo-irradiation with a KrF excimer laser at 248 nm in a vacuum chamber. The reaction was confirmed by detection of HCl with a mass spectrometer and by measurement of chlorine content on the film with X-ray photoelectron spectroscopy. UV-visible absorption spectroscopy for the laser-treated film showed the formation of new broad absorption bands in the visible and near IR region, indicating that sequential dehydrochlorination induced the formation of conjugated carbon multiple bonds in the polymer chain. Its conjugation number is estimated to be 30 for a triple bond and 10–25 for a double bond from the peak positions on the Raman spectrum of the film. ESR spectra of laser-irradiated PVDC powder also showed long-lived radicals having a narrow band width (ΔHpp = 0.15 mT), suggesting that the radicals were delocalized on the conjugated bonds. © 1998 John Wiley & Sons, Inc. J. Polym. Sci. A Polym. Chem. 36: 2483–2487, 1998
Movie S1 from Assessment of Tumor Redox Status through (<i>S</i>)-4-(3-[<sup>18</sup>F]fluoropropyl)-L-Glutamic Acid PET Imaging of System x<sub>c</sub><sup>−</sup> Activity (2023)

&lt;p&gt;Movie S1&lt;/p&gt;
Multidisciplinary “Boot Camp” Training in Cellular Bioengineering to Accelerate Research Immersion for REU Participants (2015)

Research Experiences for Undergraduates (REU) sites widely serve as the first major research gateway for undergraduates seeking a structured research experience. Given their lack of prior research skills, and the highly compressed duration of the REU programs, these students frequently encounter barriers to a seamless transition into a new laboratory environment. We hypothesized that the design of a unified short course on laboratory and analysis techniques could serve as a pivotal orientation experience. Our goal was to rapidly align student expertise to their summer research goals while also integrating the student participants into a cohesive learning community. This article discusses the design and outcomes of a Cellular Bioengineering Boot Camp, which is offered at the outset of the 10-week REU site at Rutgers. The Boot Camp provides hands-on, supervised training for techniques and procedures that are common among projects. The training establishes a common language and baseline for the REU students and allows their first laboratory experiences to be with each other, and creates an immediate network of peers and mentors. Surveys before and after the Boot Camp and at the end of the summer indicated a significant improvement in student proficiency in the techniques that was retained throughout the summer. We believe that the Boot Camp approach can be tailored to the specifics of each REU site and its associated projects and research foci.
Compensation of corneal horizontal/vertical astigmatism, lateral coma, and spherical aberration by internal optics of the eye (2004)

Both the anterior surface of the cornea and the internal optics (the posterior cornea, crystalline lens) contribute to the aberration of a wavefront passing through the eye. Artal, Guirao, Berrio, and Williams (2001) reported that the wavefront aberrations produced by the internal optics offset, or compensate for, the aberrations produced by the cornea to reduce ocular wavefront aberrations. We have investigated the wavefront aberrations of the cornea, internal optics, and complete eye on both the population and individual level to determine which aberrations are compensated and probable paths leading to that compensation. The corneal and ocular aberrations of 30 young subjects at relaxed accommodation were measured with the Topcon Wavefront Analyzer, which simultaneously measures refraction, corneal topography (videokeratoscope), and wavefront aberrations (Hartmann-Shack sensor). We found strong evidence for compensation of horizontal/vertical (H/V) astigmatism (Zernike term Z5) lateral coma (Z8) and spherical aberration (Z12). H/V astigmatism compensation is scaled for each individual, suggesting that it is actively determined by a fine-tuning process. Spherical aberration shows no individual compensation, suggesting that is a passive result of genetically determined physiology. Lateral coma shows individually scaled compensation, some of which may be attributable to eccentricity of the fovea.