gebhart/patrepeval huggingface dataset:
Micbots: Collecting large realistic datasets for speech and audio research using mobile robots (2015)

Speech and audio signal processing research is a tale of data collection efforts and evaluation campaigns. Large benchmark datasets for automatic speech recognition (ASR) have been instrumental in the advancement of speech recognition technologies. However, when it comes to robust ASR, source separation, and localization, especially using microphone arrays, the perfect dataset is out of reach, and many different data collection efforts have each made different compromises between the conflicting factors in terms of realism, ground truth, and costs. Our goal here is to escape some of the most difficult trade-offs by proposing MICbots, a low-cost method of collecting large amounts of realistic data where annotations and ground truth are readily available. Our key idea is to use freely moving robots equiped with microphones and loudspeakers, playing recorded utterances from existing (already annotated) speech datasets. We give an overview of previous data collection efforts and the trade-offs they make, and describe the benefits of using our robot-based approach. We finally explain the use of this method to collect room impulse response measurement.
Surface-enhanced Raman spectroscopy with a laser pointer light source and miniature spectrometer (2004)

The initial steps toward a miniature, field portable sensor based on surface-enhanced Raman spectroscopy (SERS) are presented. It is demonstrated that a low-cost miniaturized Raman system can be used in place of a larger, higher-cost conventional Raman system. This system was developed by sequentially replacing components of a laboratory scale Raman spectroscopy system with smaller, lower-cost, commercially available components. For example, a green laser pointer was used as the excitation source, a reflectance probe fiber-optic cable was used for laser delivery and collection, and a compact card-based spectrometer was used for dispersion and detection. Spectra, collected with the laser pointer Raman system, are presented of a resonant (Rhodamine 6G) and a non-resonant (trans-1,2-bis(4-pyridyl)ethylene) molecule as well as a self-assembled monolayer (1-decanethiol). Small, low-cost sensors are in demand for a variety of applications, and SERS is positioned to contribute significantly with its remarkable sensitivity and molecular specificity.Key words: Raman, SERS, fiber-optics, sensor.
Abstract 5567: hYP218 CAR-T cells targeting a membrane-proximal epitope of mesothelin are highly effective against mesothelin expressing cancers (2022)

Abstract Background and Hypothesis: Mesothelin is an attractive target for CAR-T cell therapy since it is highly expressed in many solid tumors but has limited expression on normal human tissues. However, anti-mesothelin CAR-T cells have shown limited efficacy in patients. Since most antibodies to mesothelin bind the membrane distal epitopes we generated antibodies that bind mesothelin in a membrane-proximal region. We hypothesize that CAR-T cells recognizing a membrane proximal epitope on mesothelin will be more efficacious. Study Design: We developed CAR-T cells targeting a membrane-distal (SS1CAR-T) and a membrane-proximal epitope (hYP218 CAR-T) of mesothelin. Using mesothelin-expressing cancer cell lines, anti-tumor efficacy of CAR-T cells was assessed in vitro by measuring direct killing of tumor cells by the CAR-T cells and quantifying cytokine-release by the CAR-T cells. In vivo anti-tumor efficacy of CAR-T was determined in NSG mice using three different solid tumor models of high-mesothelin expression: ovarian cancer (OVCAR-8), pancreatic cancer (KLM-1), and mesothelioma patient-derived xenograft (NCI-Meso63). Blood and tumor infiltration of CAR-T cells in vivo was determined via flow cytometry analysis. Results: Upon co-culture with tumor cells with high mesothelin expression (A431-H9, OVCAR-8, KLM-1, H226, NCI-Meso63, NCI-Meso29), hYP218 CAR-T cells killed cancer cells more efficiently than SS1 CAR-T cells, with a 2-4-fold lower ET50 value (Effector to Target ratio for 50% killing of tumor cells). Additionally, compared to SS1 CAR-T cells, hYP218 CAR-T cells secreted significantly higher level of cytokines (IL-2, TNFα, IFNγ) in a co-culture with tumor cells. In three solid tumor models, single treatment of tumor-bearing mice with hYP218 CAR-T cells lead to improved tumor response and survival compared to SS1 CAR-T, with complete regression of OVCAR-8 and NCI-Meso63 tumors. Compared to SS1 CAR-T cells, higher hYP218 CAR-T cell infiltration was detected both in the blood and tumors isolated from hYP218 CAR-T treated mice seven days post-treatment. Conclusion: We demonstrate that hYP218 CAR-T cells targeting a membrane-proximal epitope of mesothelin are more potent than similar CAR-T cells targeting a membrane distal epitope. Increased accumulation of hYP218 CAR-T cells in the tumor may explain their increased efficacy. These results support its clinical development to treat patients with mesothelin expressing cancers. Citation Format: Sakshi Tomar, Jingli Zhang, Nan Li, Ira Pastan, Mitchell Ho, Raffit Hassan. hYP218 CAR-T cells targeting a membrane-proximal epitope of mesothelin are highly effective against mesothelin expressing cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5567.
New extensional rheometer for creep flow at high tensile stress. Part II. Flow induced nucleation for the crystallization of iPP (2004)

See also companion Extensional rheometer for creep flow at high tensile stress. Part I. Description and validation
Highly Active Ruthenium Catalyst Supported on Magnetically Separable Mesoporous Organosilica Nanoparticles (2020)

A facile and direct method for synthesizing magnetic periodic mesoporous organosilica nanoparticles from pure organosilane precursors is described. Magnetic ethylene- and phenylene-bridged periodic mesoporous organosilica nanoparticles (PMO NPs) were prepared by nanoemulsification techniques. For fabricating magnetic ethylene- or phenylene-bridged PMO NPs, hydrophobic magnetic nanoparticles in an oil-in-water (o/w) emulsion were prepared, followed by a sol–gel condensation of the incorporated bridged organosilane precursor (1,2 bis(triethoxysilyl)ethane or 1,4 bis(triethoxysilyl)benzene), respectively. The resulting materials were characterized using high-resolution scanning electron microscopy (HR-SEM), high-resolution transmission electron microscopy (HR-TEM), energy-dispersive X-ray (EDX) spectroscopy, powder X-ray diffraction (XRD), solid-state NMR analysis, and nitrogen sorption analysis (N2-BET). The magnetic ethylene-bridged PMO NPs were successfully loaded using a ruthenium oxide catalyst by means of sonication and evaporation under mild conditions. The obtained catalytic system, termed Ru@M-Ethylene-PMO NPS, was applied in a reduction reaction of aromatic compounds. It exhibited very high catalytic behavior with easy separation from the reaction medium by applying an external magnetic field.
Efficient Method for the Preparation of Primary, Inverted Secondary and Tertiary Alkyl Carboxylates from Alcohols and Carboxylic Acids by a New Type of Oxidation–Reduction Condensation Using Simple 1,4-Benzoquinone (2003)

Abstract A new type of oxidation–reduction condensation using in situ formed alkoxydiphenylphosphines (i.e., diphenylphosphinite esters), easily available 1,4-benzoquionone and carboxylic acids provides a new and efficient method for the preparation of alkyl carboxylates from the corresponding alcohols under mild and neutral conditions. Further, the yields of the corresponding inverted carboxylates were equally high in the case of chiral secondary or tertiary alcohols.
Daylight Imagery of Ocean Surface Waves for Wave Spectra (1981)

Both surface-reflected daylight and upwelling light are modeled to second order to help provide a quantitative and physically interpretable description of daylight imagery of ocean surface waves for wave spectra. An image recording of the slope-modulated reflected and upwelled radiance can be optically analyzed to provide the surface slope spectrum as a function of wavenumber for a particular patch on the ocean surface. Sources of error involved in obtaining ocean spectral information from daylight imagery are outlined and methods of alleviating them discussed. Errors resulting from the nonlinear nature of the transfer function relating wave slope to radiance at the, sensor are, shown to be minimized using the second-order theory in evaluating potential sensor geometries. The directional sensitivity of daylight imagery to waves traveling in various directions is also evaluated. A modified Pierson wave spectrum was used to generate numerically a one-dimensional wave-slope profile. This slope profile was used as input to a numerical model that generated a modulation of radiance at the sensor. The spectrum of this radiance modulation agreed favorably with the original Pierson spectrum.
Interference management via capacity-achieving codes for the deterministic broadcast channel (2005)

We motivate the consideration of deterministic broadcast channel coding as an interference management technique in wireless scenarios. We address practical coding strategies for such channels and discuss two approaches. The first relies upon enumerative source coding and can be applied for any deterministic broadcast channel problem as the first step in pipelined encoding for vertex rates. The second approach addresses a wireless interference management scenario and is a complete, practical, capacity-achieving strategy that dualizes the Luby transform code construction and encoding/decoding algorithms. This results in the first practical, nontrivial, capacity achieving code construction for the deterministic broadcast channel.
Electrochemical Capacitors using Impurity-free Single- walled Carbon Nanotubes (2006)

Abstract not Available.
An Endostatin-derived Peptide Interacts with Integrins and Regulates Actin Cytoskeleton and Migration of Endothelial Cells (2004)

Endostatin, the C-terminal fragment of collagen XVIII, is a potent inhibitor of angiogenesis and endothelial cell migration. To define its critical cell interaction domains we used endostatin-derived synthetic peptides containing surface-exposed sequences. We observed that, when immobilized, an arginine-rich peptide of 11 amino acids from its N terminus efficiently promoted endothelial cell adhesion through beta(1) integrin- and heparin-dependent mechanisms. In addition, the peptide induced the formation of membrane ruffles and focal contacts. In the soluble form, the peptide inhibited basic fibroblast growth factor-induced directional migration and tubular morphogenesis of microvascular endothelial cells. Accordingly, the peptide induced the loss of focal adhesions and actin stress fibers in these cells. Substitution of the arginine residues with alanines resulted in the loss of these properties. In the current study we describe a putative integrin-binding sequence with anti-migratory activity within endostatin.
Impact of tetanus-diphtheria-acellular pertussis immunization during pregnancy on subsequent infant immunization seroresponses: follow-up from a large randomized placebo-controlled trial (2019)

ClinicalTrials.gov: NCT02422264.
Thermochemistry of the Gaseous Vanadium Chlorides VCl, VCl2, VCl3, and VCl4 (2008)

Gaseous equilibria in the V-Ag-Cl system were studied at elevated temperatures by effusion-beam mass spectrometry, where the pertinent species were generated by reaction of Cl 2(g) with V + Ag granules in the effusion cell source. Reaction enthalpies were derived from the equilibrium data, and the standard enthalpies of formation at 298 K of gaseous VCl, VCl2, and VCl3 were found to be +49.7, -34.8, and -85.6 kcal mol(-1), respectively. The corresponding bond dissociation energies at 298 K are D(V-Cl) = 102.9 kcal, D(ClV-Cl) = 113.5 kcal, D(Cl2V-Cl) = 79.8 kcal, and D(Cl3V-Cl) = 69.5 kcal. From these data, the dissociation energy D degrees 0(VCl) = 101.9 kcal mol(-1) or 4.42 eV is obtained. An alternate value, Delta(f)H(o)298(VCl 3,g) = -87.0 kcal mol (-1) was derived from third-law analysis of literature sublimation data for VCl3(s). In addition, literature thermochemical data on VCl4(g) were re-evaluated, leading to Delta(f)H(o)298 = -126.1 kcal mol (-1). The results are compared with various estimates in the literature.
Acoustic impulse response in apple tissues treated by pulsed electric field (2010)

This work discusses application of acoustically-derived index of disintegration for characterization of pulsed electric field (PEF)-treated whole apples in aqueous media. It was demonstrated that PEF efficiency was dependent on the conductivity of the aqueous media and orientation of the apple with respect to the external field. Electrical treatment also stimulated transient changes after PEF application in acoustic disintegration index (Za). Relation between the conductivity disintegration index (Zc) and Za was established. A non-linear relation between Zc and Za was observed and it was demonstrated that the Za value seems to be a better measure of the real degree of damage than the widely used value of Zc.
Softwarisation et Webification, la révolution logicielle des réseaux (2016)

International audience
Supplemental Table 1 from Human Chorionic Gonadotropin Does Not Correlate with Risk for Maternal Breast Cancer: Results from the Finnish Maternity Cohort (2023)

&lt;p&gt;Supplemental Table 1. Distribution of Covariates by hCG Quartiles: Finnish Maternity Cohort&lt;/p&gt;
Differential effects of low and high concentrations of interleukin 6 on human B cells (1990)

In this report we have studied the functional effects of a wide range of interleukin 6 concentrations on human B cells. B cells purified from tonsils and from five of six spleens proliferated directly in a dose-dependent manner in the presence of low concentrations (1-100 pg/ml) of IL 6 whereas B cells from the sixth spleen proliferated only after in vitro anti-mu antibodies activation. Only large B cells (presumably in vivo activated B cells) were responsive to IL 6. High concentrations of IL 6 (1-10 ng/ml) did not trigger B cell proliferation but were able to up-regulate the expression of the B5 activation antigen on B cells, whereas the expression of two other B cell antigens (CD20 and CD23) was unchanged. At all concentrations of IL 6 tested (0.01-10 ng/ml) no B cell differentiation occurred after 7 days culture. Depletion before culture of B5+ cells from the B cell-enriched spleen cell preparation abolished both the proliferative effect and up-regulation of B5 antigen induced by IL 6, indicating that this lymphokine acted primarily on activated B cells. This differential effect of "low" and "high" concentrations of IL 6 on activated B cells may solve controversy on the role of IL 6 as an early or late agent in B cell maturation.
Impact of Myocardial Ischemia and Reperfusion on Ventricular Defibrillation Patterns, Energy Requirements, and Detection of Recovery (2002)

Spontaneous VF can be halted by a shock but then quickly restart before a standard ECG amplifier has recovered from postshock saturation, making it appear that the shock failed.
Stress/strain performance of sheathed bismuth-2223 superconductors (1997)

Besides possessing high current transport properties, superconductors employed in several applications must also be capable of retaining those properties when subjected to stresses and strains. This paper explores the potential for Consil, an alloy containing Ag, 0.25 wt% Ni and 0.25 wt.% Mg, to serve as a potential sheathing material in the processing of BSCCO (2223) superconductors. Strain tolerance measurements at 77 K and 0 Tesla indicate superior performance by Consil-sheathed tapes over tapes sheathed in commercially pure Ag. While the pure Ag undergoes an abrupt decrease in critical current (I{sub c}) beyond a certain strain level (0.2% strain), Consil-sheathed tapes show a more gradual decrease. However, despite their superior performance under strain, the Consil-sheathed tapes did not yield critical current density (J{sub c}) values that are normally obtained in Ag-sheathed tapes. The reason for this behavior has been attributed to poor phase conversion of the superconducting core inside the Consil sheath, even after extended sintering times (250 h).
Editorial: Antimicrobial Photodynamic Therapy: A New Paradigm in the Fight Against Infections (2021)

According to a 2019 report from the Center for Disease Control and Prevention (CDC), more than 2.8 million antibiotic-resistant infections occur in the U.S. each year, and more than 35, 000 people die as a result. This special issue is focused on Antimicrobial Photodynamic Therapy (PDT), which is a new strategy to fight against infections. PDT is mostly used in the treatment of cancer, and non-melanoma skin cancer is the most widely recognized indication. A photosensitizer that is activated by visible light in the presence of oxygen can generate reactive oxygen species resulting in the death of the microorganisms, without damaging the surrounding tissue. This innovative way of destroying microbial pathogens has many advantages compared with the conventional antimicrobials and antibiotics used so far. It has a broad spectrum of action, being able to kill or inactivate bacteria, fungi, viruses and protozoa...
The surface-potential-based compact model HiSIM-SOI for Silicon-On-Insulator MOSFETs (2009)

The compact circuit simulation model HiSIM-SOI for Silicon-On-Insulator (SOI)-MOSFET solves the three surface potentials of the SOI-MOSFET accurately without sacrificing simulation time. Depending on device structure and biasing conditions the SOI-MOSFET device may operate in partially depleted (PD) or fully depleted (FD) modes and a smooth transition between these modes is prerequisite for a good compact model. HiSIM-SOI is verified to fulfill these requirements and to cover all the operational regions of SOI-MOSFETs. It is also demonstrated that the floating-body effect, which determines key SOI-MOSFET properties like the kink effect or the history effect, can be accurately captured within the model calculation in a simple way without introducing an additional node in the compact model. Furthermore, HiSIM-SOI correctly reproduces measured data of both body-contact and floating-body devices.
Relationship between order parameter and physical constants in fluorinated liquid crystals (1997)

Abstract We have investigated the relationship between order parameter and physical constants (dielectric anisotropy and splay elastic constant) for fluorinated liquid crystals with a small temperature coefficient of the threshold voltage. In these special fluorinated liquid crystals, the dielectric anisotropy is proportional to the square of the order parameter. We have found that this anomalous dielectric behaviour affects the small temperature coefficient of the threshold voltage.
Insights into the Structural Changes Occurring upon Photoconversion in the Orange Carotenoid Protein from Broadband Two-Dimensional Electronic Spectroscopy (2014)

Carotenoids play an essential role in photoprotection, interacting with other pigments to safely dissipate excess absorbed energy as heat. In cyanobacteria, the short time scale photoprotective mechanisms involve the photoactive orange carotenoid protein (OCP), which binds a single carbonyl carotenoid. Blue-green light induces the photoswitching of OCP from its ground state form (OCPO) to a metastable photoproduct (OCPR). OCPR can bind to the phycobilisome antenna and induce fluorescence quenching. The photoswitching is accompanied by structural and functional changes at the level of the protein and of the bound carotenoid. Here, we use broadband two-dimensional electronic spectroscopy to study the differences in excited state dynamics of the carotenoid in the two forms of OCP. Our results provide insight into the origin of the pronounced vibrational lineshape and oscillatory dynamics observed in linear absorption and 2D electronic spectroscopy of OCPO and the large inhomogeneous broadening in OCPR, with consequences for the chemical function of the two forms.
5‐lipoxygenase‐activating protein is an arachidonate binding protein (1993)

5-Lipoxygenase-activating protein (FLAP) is an 18-kDa integral membrane protein which is essential for cellular leukotriene (LT) synthesis, and is the target of LT biosynthesis inhibitors. However, the mechanism by which FLAP activates 5-LO has not been determined. We have expressed high levels of human FLAP in Spodoptera frugiperda (Sf9) insect cells infected with recombinant baculovirus, and used this system to demonstrate that FLAP specifically binds [125I]L-739,059, a novel photoaffinity analog of arachidonic acid. This binding is inhibited by both arachidonic acid and MK-886, an LT biosynthesis inhibitor which specifically interacts with FLAP. These studies suggest that FLAP may activate 5-LO by specifically binding arachidonic acid and transferring this substrate to the enzyme.
Specific substitutions at amino acid 256 of the sarcoplasmic/endoplasmic reticulum Ca2+transport ATPase mediate resistance to thapsigargin in thapsigargin-resistant hamster cells. (1998)

Dr. Zhong's name was misspelled. It is correct in the author line above.
Constitutive Activation of STATs Upon In Vivo Human Immunodeficiency Virus Infection (1999)

Infection by the human immunodeficiency virus (HIV) either upregulates or downregulates the expression of several cytokines and interferons (IFNs) that use the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway for signal transduction. However, very little is known on the state of activation of the JAK/STAT pathway after HIV infection either in vivo or in vitro. In this regard, we report here that a constitutive activation of a C-terminal truncated STAT5 (STAT5triangle up) and of STAT1alpha occurs in the majority ( approximately 75%) of individuals with progressive HIV disease. We have further demonstrated that, among peripheral blood mononuclear cells (PBMCs), STAT5triangle up is activated preferentially in CD4(+) T cells. In contrast to a published report, expression of STATs from PBMCs of infected individuals was comparable with that of seronegative donors. In addition, in vitro infection of mitogen-activated PBMCs with a panel of laboratory-adapted and primary HIV strains characterized by differential usage of chemokine coreceptors did not affect STAT protein levels. However, enhanced activation of STAT was observed after in vitro infection of resting PBMCs and nonadherent PBMCs by different viral strains. Thus, constitutive STAT activation in CD4(+) T lymphocytes represents a novel finding of interest also as a potential new marker of immunological reconstitution of HIV-infected individuals.
Effects of vacuum ultraviolet radiation on deposited and ultraviolet-cured low-k porous organosilicate glass (2011)

The authors compare the effects of vacuum ultraviolet (VUV) irradiation on pristine and UV-cured low-k porous organosilicate glass (SiCOH). The authors find that during VUV irradiation, more trapped charges are generated in UV-cured SiCOH as compared to pristine SiCOH. VUV is also used as a tool to investigate effects of UV curing. From comparison of VUV spectroscopy and photoinjection current of the two samples, the authors find that UV curing reduces the number of defect states in SiCOH. The authors also find that UV-cured SiCOH has higher photoconductivity and intrinsic conductivity from VUV spectroscopy and trapped-charge decay rate, respectively.