gebhart/patrepeval huggingface dataset:
Soluble Fibrinogen-Like Protein 2/Fibroleukin Exhibits Immunosuppressive Properties: Suppressing T Cell Proliferation and Inhibiting Maturation of Bone Marrow-Derived Dendritic Cells (2003)

Fibrinogen-like protein 2 (fgl2)/fibroleukin is a member of the fibrinogen-related protein superfamily. In addition to its established role in triggering thrombosis, it is known to be secreted by T cells. The soluble fgl2 ((s)fgl2) protein generated in a baculovirus expression system bound to both T cells and bone marrow-derived dendritic cells (DC) in a specific manner. (s)fgl2 exhibited immunomodulatory properties capable of inhibiting T cell proliferation stimulated by alloantigens, anti-CD3/anti-CD28 mAbs, and Con A in a dose-dependent manner; however, it had no inhibitory effects on CTL activity. The time- and dose-dependent inhibitory effect of (s)fgl2 on alloreactive T cell proliferation could be neutralized by a mAb against mouse fgl2. Polarization toward a Th2 cytokine profile with decreased production of IL-2 and IFN-gamma and increased production of IL-4 and IL-10 was observed in (s)fgl2-treated allogeneic cultures. Exposure of immature DC to (s)fgl2 abrogated the expression of CD80(high) and MHC class II(high) molecules and markedly inhibited NF-kappaB nuclear translocation, thus inhibiting their maturation. (s)Fgl2-treated DC had an impaired ability to stimulate allogeneic T cell proliferation. Maximal inhibition of proliferation was observed when allogeneic T cells were cultured with (s)fgl2-treated DC and (s)fgl2 protein was added in the culture. These data provide the first evidence to demonstrate that (s)fgl2 exerts immunosuppressive effects on T cell proliferation and DC maturation.
An identity for the nonparametric maximum likelihood estimator in missing data and biased sampling models (1995)

We derive an identity for the maximum likelihood estimator in nonparametric missing data models and biased sampling models, which almost says that this estimator is efficient. Application of empirical process theory to the identity provides us with a straightforward consistency and efficiency proof. The identity is illustrated with the random truncation model.
Quantitative PCR for Tracking the Megaplasmid-Borne Biodegradation Potential of a Model Sphingomonad (2012)

We developed a quantitative PCR method for tracking the dxnA1 gene, the initial, megaplasmid-borne gene in Sphingomonas wittichii RW1's dibenzo-p-dioxin degradation pathway. We used this method on complex environmental samples and report on growth of S. wittichii RW1 in landfill leachate, thus furnishing a novel tool for monitoring megaplasmid-borne, dioxygenase-encoding genes.
OPTIMIZATION OF THE WHEELER CAP TECHNIQUE FOR EFFICIENCY MEASUREMENT OF RFID ANTENNAS MATCHED TO COMPLEX LOADS (2021)

International audience
Synthesis of tetradehydrocorrins, corroles, and corrologens related to 12-decarboxyuroporphyrin III and uroporphyrin III (1978)

The title compounds have been synthesized, for the first time, from the corresponding 1,19-dimetyl-, 1-methyl-19-iodo-, and 1,19-di-iodo-biladiene-ac derivatives respectively, by means of methods described earlier. The 1,19-di-iodobiladienes-ac could be cyclized, in the presence of sodium azide, to the corresponding 20-azaporphyrins.
The Blood-Brain Barrier in Normal CNS and in Metal-Induced Neurotoxicity (2023)

In this chapter, we review the interaction of metals with the blood-brain barrier (BBB), stressing interactions that may underlie the neurotoxic effects of these metals. It will be necessary to review the ways in which the metals cross the blood-brain barrier (by simple diffusion or by specific transport mechanisms), as well as ways in which a secondary neurotoxicity can be produced by a primary toxic action of the metals on the BBB. To set the context for the discussion, we begin with a review of current understanding of the structure and general transport functions of the BBB.
4. Pathology of African swine fever (2021)

African swine fever (ASF) is a haemorrhagic viral disease of domestic pigs and wild boar (both Sus scrofa species) that seriously impacts pig production worldwide. Pathology plays a key role not only in identifying and characterising macroscopic and histopathological lesions, but also in studying pathogenesis, thus complementing other disciplines to provide a broad understanding of host-virus interactions, which contributes to the development of vaccines and therapies. The aim of the present chapter is to provide a compilation of the most characteristic macroscopic and histopathological lesions associated with the different clinical forms of ASF (peracute, acute, subacute and chronic). Another aim is to present the current state of knowledge regarding ASF pathogenesis, with special attention to target cells, virus distribution and virus load in multiple organ locations and its correlation with the appearance of clinical signs and lesions from early stages to terminal disease. For that purpose, the chapter includes a complete collection of original macroscopic and microscopic photographs, the latter including illustrations of haematoxylin and eosin-stained sections and immunohistochemistry to identify the ASF-virus (ASFV). The photographs were obtained from experimental infections with ASFV isolates of different virulence carried out over the last two decades in different research centres. The purpose is to provide a reference that may be useful for the early recognition of ASF by veterinary practitioners working in the field and researchers focused on characterising new ASFV isolates or testing new vaccines and treatments.
M4 muscarinic acetylcholine receptor modulation of associative learning and behavioral flexibility in a novel touchscreen cognitive assessment (845.8) (2014)

Recent findings indicate that selective activation of the M4 muscarinic acetylcholine receptor (M4 mAChR) may represent a novel treatment approach for the psychotic symptoms and cognitive disturbances observed in several neuropsychiatric disorders. In the present studies, cognitive performance of M4 mAChR knock‐out mice (M4‐KO mice) was examined across a series of computer touchscreen‐based pairwise discrimination tasks assessing susceptibility to interference from previously learned competing sets of information. While M4‐KO mice acquired the initial discrimination task in a similar number of sessions as wildtype mice, the M4‐KO mice showed impaired acquisition on all subsequent visual discriminations. In addition, the novel M4 positive allosteric modulator VU0467154 reversed disruptions in pairwise discrimination induced by MK‐801, an antagonist of the N‐methyl‐D‐aspartate subtype of glutamate receptors. These data reveal that selective M4 mAChR activation is critical for modulation of normal associative learning and behavioral flexibility in visual discrimination tasks. Moreover, our studies suggest that selective M4 PAMs may have therapeutic potential for the treatment of cognitive deficits observed in patients with schizophrenia. Grant Funding Source : This work was funded by grants# 2R01 MH73676‐06, 1R01 MH086601‐04, AstraZeneca.
Performance Characterization and Call Reliability Diagnosis Support for Voice over LTE (2015)

To understand VoLTE performance in a commercial deployment, in this paper we conduct the first comprehensive performance characterization of commercially deployed VoLTE, and compare with legacy call and over-the-top (OTT) VoIP call. We confirm that VoLTE excels in most metrics such as audio quality, but its call reliability still lags behind legacy call for all the three major U.S. operators. We propose an on-device VoLTE problem detection tool, which can capture new types of problems concerning audio quality with high accuracy and minimum overhead, and perform stress testing on VoLTE call's reliability. We discover 3 instances of problems in the early deployment of VoLTE lying in the protocol design and implementation. Although the identified problems are all concerned with the immature LTE coverage in the current deployment, we find that they can cause serious impairment on user experience and are urgent to be solved in the developing stage. For example, one such instance can lead to up to 50-second-long muting problem during a VoLTE call! We perform in-depth cross-layer analysis and find that the causes are rooted in the lack of coordination among protocols designed for different purposes, and invalid assumptions made by protocols used in existing infrastructure when integrated with VoLTE. We summarize learnt lessons and suggest solutions.
Localization of the Wilson disease protein in murine intestine (2008)

Wilson disease is an inherited disorder of human copper metabolism, characterized by accumulation of copper, predominantly liver and brain. The gene defect lies in the Wilson disease protein ATP7B, a copper transporting ATPase highly active in hepatocytes. In the liver ATP7B is essential for excretion of excess copper into the bile and for copper loading of ceruloplasmin in the Golgi apparatus. The extrahepatic role of ATP7B is not yet completely understood. We analyzed the intestinal expression of ATP7B in mice by RT-PCR, Western Blot and indirect immunofluorescence. We find abundant expression of ATP7B in stomach and small intestine, but not in colon. Using confocal microscopy we demonstrate a Golgi localization of ATP7B in enterocytes. In response to elevated copper, the Wilson disease protein shows a unique intracellular trafficking pattern in the intestinal polarized cell line CaCo-2, moving away from the Golgi apparatus to dispersed vesicles. In contrast to the closely related copper transporting ATPase ATP7A, we could neither in mouse tissues nor in CaCo-2 cells demonstrate a plasma membrane localization of ATP7B. This suggests a role for intestinal ATP7B in sequestration of copper in intracellular vesicles for maintenance of copper homeostasis in the enterocyte. In conclusion, the expression of ATP7B in the small intestine might represent an additional regulatory mechanism to fine-tune intestinal copper absorption.
Diversity of nonribosomal peptide synthetase and polyketide synthase gene clusters in the genus <i>Acrocarpospora</i> (2020)

Acrocarpospora is a rare, recently established actinomycete genus of the family Streptosporangiaceae. In the present study, we sequenced whole genomes of the type strains of Acrocarpospora corrugate, Acrocarpospora macrocephala, and Acrocarpospora pleiomorpha to assess their potency as secondary metabolite producers; we then surveyed their nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) gene clusters. The genome sizes of A. corrugate NBRC 13972<sup>T</sup>, A. macrocephala NBRC 16266<sup>T</sup>, and A. pleiomorpha NBRC 16267<sup>T</sup> were 9.3 Mb, 12.1 Mb, and 11.8 Mb, respectively. Each genome contained 12-17 modular NRPS and PKS gene clusters. Among the 23 kinds of NRPS and PKS gene clusters identified from the three strains, eight clusters were conserved in all the strains, six were shared between A. macrocephala and A. pleiomorpha, and the remaining nine were strain-specific. We predicted the chemical structures of the products synthesized by these gene clusters based on bioinformatic analyses. Since the chemical structures are diverse, Acrocarpospora strains are considered an attractive source of diverse nonribosomal peptide and polyketide compounds.
OCT-Based Velocimetry for Blood Flow Quantification (2019)

Current clinically available OCTA imaging methods are able to reliably distinguish retinal regions of significant flow from static tissue by evaluating the backscattered OCT signal from repeated measurements. By accurately controlling time delay and position offset between repeated acquisitions, quantitative OCT-based measurements of the underlying blood flow velocity and flow rate are additionally enabled. Multiple methods have been developed for this purpose that operate either on phase, amplitude, or the complex OCT signal and, accordingly, build on different physical models for interpreting the OCT signal modulation arising from moving red blood cells. Here, we present an overview of the technical background of OCT-based methods for quantitative velocimetry, describe their application for retinal imaging in vivo, and discuss their potential and limitations for future clinical ophthalmic applications.
24‐3: High‐Color‐Gamut OLED Displays with Reduced Power Consumption for Laptop Applications (2021)

In this paper we discuss the benefits that can be realized by phosphorescent OLED technology for low power consumption high color gamut displays. We show that relative to LCD based displays, the higher the display color gamut, the more OLED displays have a power consumption advantage over LCDs, enabling high performance displays for laptops. Based on Intel's day in life PC usage model, our simulation shows that DCI‐P3 and 97% BT2020 color profiles will deliver 13% and 18% improvement respectively in battery life for OLEDs versus equivalent LCDs.
Adverse Pathological Findings at Radical Prostatectomy following Active Surveillance: Results from the Movember GAP3 Cohort (2022)

Background: Little is known about the consequences of delaying radical prostatectomy (RP) after Active Surveillance (AS) according to stringent or wider entry criteria. We investigated the association between inclusion criteria and rates, and timing of adverse pathological findings (APFs) among patients in GAP3 cohorts. Methods: APFs (GG ≥ 3, pT ≥ 3, pN > 0 and positive surgical margins [R1]) were accounted for in very low-risk (VLR: grade group [GG] 1, cT1, positive cores < 3, PSA < 10 ng/mL, PSA density [PSAD] < 0.15 ng/mL/cm3) and low-risk (LR: GG1, cT1-2, PSA ≤ 10 ng/mL) patients undergoing subsequent RP. The Kaplan−Meier method and log−rank test analyzed APF-free survival. Stratified mixed effects models analyzed association. Results: Out of 21,169 patients on AS, 1742 (VLR: 721; LR: 1021) underwent delayed RP. Most (60.8%) did not have APFs. APFs occurred more frequently (44.6% vs. 31.7%; OR 1.54, p < 0.001) and earlier (median time: 40.3 vs. 62.6 months; p < 0.001) in LR patients, and consisted of pT ≥ 3 (OR 1.47, p = 0.013) or R1 (OR 1.80, p < 0.001), but not of GG ≥ 3 or node involvement. Age (OR 1.05, p < 0.001), PSAD (OR 23.21, p = 0.003), and number of positive cores (OR 1.16, p = 0.004) were independently associated with APFs. Conclusions: AS stands as a safe option for low-risk patients, and most do not have APFs at surgery. Wider entry criteria are associated with pT3 and R1. The prognostic implications remain uncertain.
Measurements of the group delay and the group delay dispersion with resonance scanning interferometer (2013)

We developed a method for group delay and group delay dispersion measurements, based on location of interference resonance peaks. Such resonance peaks can be observed in transmittance or in reflectance when two mirrors are placed parallel to each other and separated by a thin air spacer. By using a novel approach, based on simultaneous processing of the data acquired for different spacer distances we obtained reliable results with high resolution. Measurements were performed both in transmittance and reflectance layouts depending on the reflectivity of the mirror to be measured. The developed method allows dispersion measurements of ultraviolet mirrors and ultra-broadband mirrors spanning more than one optical octave to be performed.
Combining smart phone and infrastructure sensors to improve security in enterprise settings (2013)

There is an increasing trend among employees to bring in their own personal device to work, thereby making the enterprise more vulnerable to security attacks such as data leakage from phones. Additionally, users are increasingly running phone apps in a mixed-mode i.e. both for enterprise and personal commitments. For example, phone cameras and microphones are used to record business meetings, often resulting in the case that both employers and employees become unaware of the existence of business data on the phone at a later point in time. The lack of employer control over personal devices raises enterprise data leakage threats, when an employee's phone is lost or stolen. In this paper we describe a system that leverages sensors available on the phone as well as on the enterprise infrastructure to identify business data resident on the phone for further secure handling. Office spaces have traditionally been instrumented with badge swipe readers, cameras, wifi access points etc. that can be used to provide passive sensory data about employees. For example, badge swipes can be used provide approximate location information of an employee where as calendar entries provide information about their schedule and activities. We propose a distributed architecture that leverages the context of the user for speculatively identifying enterprise data from personal data. The basic idea is to understand whether a user is engaged in enterprise or personal work by inferring her context from a combination of phone and infrastructure sensors. The contextual attributes in our system, such as location, can be sourced from a plurality of sensors on the phone as well as on the infrastructure. We exploit this diversity and propose a cost optimized distributed rule execution framework that chooses the optimal set of predicates to sense on the phone as well as on the infrastructure to reduce sensing cost. Furthermore, the framework also chooses the appropriate site for rule evaluation, either on the infrastructure or phone, to optimize for network transfer cost incurred due to shipping of sensed predicates between the two sites. Combined together,the above two optimizations reduce the battery drain caused due to context inferencing on the phone.
Separation of Organic Compounds by Gradient Simulated Moving Bed Chromatography (2006)

A promising solution for the separation of organic compounds in pharmaceutical industry is the gradient simulated moving bed chromatography (SMB). The above mentioned process can be used for the production of high purity materials (isomers, optical isomers, biomolecules). We assumed isotherm, isochor equilibrium adsorption (competitive multicomponent Langmuir-adsorption equilibrium) in the mathematical model and neglected the effects of axial dispersion. In our present work we extended the mathematical model with solvent adsorption-desorption processes (acetone-dichloromethane eluent, steroid compounds, silicagel). The mathematical model was solved by finite differences numerical mathematical method using PC. The gradient SMB separations were carried out with a laboratory scale four column equipment in open loop system at 1:1:2:0 column configuration. The SMB equipment (L=25 cm, I.D.=1 cm) was planned and constructed for separation of a steroid mixture using YMC S-50 silica gel as adsorbent (specific surface=798.63 m g). The effect of switching time change (5.5 min, 9 min, 11.5 min, 22.5 min) on component separation was examined. During our measurements the amount of acetone in dichloromethane was 55 % v/v in the fresh eluent and pure dichloromethane in the feed. The process variables of the gradient SMB (product purity, yield, productivity, specific solvent consumption) are very favourable. Our conclusion is that the measured and the calculated data agree well and we have produced more than 99.9 %m/m purity and 90 % yield , productivity 1300-3000 g steroid kg adsorbent day at 0.1-0.3 m fresh eluent kg steroid eluent consumption.
Cine Phase-Contrast MR Flow Measurements (1994)

The magnitude threshold method of vessel edge detection developed in this study yields flow measurements that are accurate in the model system and have significantly less interuser variability than the manual method. This method shows promise for improving the precision of cine phase contrast flow measurements.
Lu 2 O 3 :Eu scintillator screen for x-ray imaging (2004)

We report on a new x-ray converter screen based on the powdered Lu<sub>2</sub>O<sub>3</sub>:Eu scintillator. Lu<sub>2</sub>O<sub>3</sub>:Eu offers high density (9.4 g/cm<sup>3</sup>), high average atomic number (63), and a peak emission of 610 nm. The high density of the material and a high packing fraction of the coating provide higher x-ray absorption efficiency, even with thin screens. As a result Lu<sub>2</sub>O<sub>3</sub>:Eu screens are expected to provide superior spatial resolution and x-ray stopping power compared to commercial powdered screens. This newly developed screen has excellent imaging performance and offers several practical advantages such as ease of fabrication, low cost, and durability. This paper will discuss preliminary results of the imaging performance of this novel screen.
Ethanol-Induced Contractions in Cerebral Arteries (2001)

The present study suggests that activation of protein tyrosine kinases (including the src family) and MAPK appear to play important roles in the ethanol-induced contractions and the elevation of [Ca(2+)](i) in smooth muscle cells from canine basilar arteries. The results could be used to suggest that selective antagonists of protein tyrosine kinases and MAPK may be useful both prophylactically and therapeutically in alcohol-induced strokes.
Testosterone Replacement Therapy in Men with Prostate Cancer: A Time-Varying Analysis (2014)

TRT following prostate cancer diagnosis and treatment does not increase mortality or the use of salvage ADT. Using time-varying analysis, we demonstrate that longer duration of TRT is not associated with adverse mortality or greater need for ADT.
An analytic expression for the field dependence of FRINGE Zernike polynomial coefficients in rotationally symmetric optical systems (2010)

Zernike polynomials have emerged as the preferred method of characterizing as-fabricated optical surfaces. From here, over time, they have come to be used as a sparsely sampled representation of the state of alignment of assembled optical systems both during and at the conclusion of the alignment process. We show here that it is possible to develop the field dependence that analytically interconnects the coefficients of the Zernike polynomial (which has to-date been characterized only by its aperture dependence) as a more complete representation of an aligned rotationally symmetric optical system and in a paper to follow a misaligned optical system. This significant expansion to this valuable polynomial provides an important new tool for characterizing high performance optical systems throughout the optical design, fabrication, assembly, and interim and acceptance test process.
ContactOpt: Optimizing Contact to Improve Grasps (2021)

Physical contact between hands and objects plays a critical role in human grasps. We show that optimizing the pose of a hand to achieve expected contact with an object can improve hand poses inferred via image-based methods. Given a hand mesh and an object mesh, a deep model trained on ground truth contact data infers desirable contact across the surfaces of the meshes. Then, ContactOpt efficiently optimizes the pose of the hand to achieve desirable contact using a differentiable contact model. Notably, our contact model encourages mesh interpenetration to approximate deformable soft tissue in the hand. In our evaluations, our methods result in grasps that better match ground truth contact, have lower kinematic error, and are significantly preferred by human participants. Code and models are available online <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> .
Reduction in coherent cross talk in WDM add/drop multiplexing nodes by path-length misalignment (1998)

Summary form only given. We propose and analyze a method of reducing the effects of coherent cross talk in a WDM add/drop multiplexer by purposely introducing a delay between different cross-talk paths. For a 16-channel WDM system, this method reduces the requirement for the multiplexer/demultiplexer cross talk by /spl sim/10 dB for return to zero and /spl sim/5 dB for nonreturn to zero transmission.