gebhart/patrepeval huggingface dataset:
A case in Europe of feline histoplasmosis apparently limited to the skin (2013)

Background Histoplasma capsulatum has a worldwide distribution, but reports in Europe remain rare. We present the second report of histoplasmosis in a cat in Europe and, to the best of our knowledge, the first case of feline histoplasmosis infection apparently limited to the skin. Case report A 6‐year‐old male castrated outdoor cat was presented to the dermatology service with a history of skin lesions evolving over 1 month and consisting of multiple papules and nodules on the head and neck. General examination was unremarkable. Cytological examination of the ulcerated nodules revealed a pyogranulomatous infiltrate, with numerous macrophages containing oval yeast‐like cells, 2–5 μm in size, with a central, lightly basophilic core surrounded by a clear halo. A tentative diagnosis of fungal infection was made, and skin biopsy specimens were taken. Histological examination confirmed the cytology findings, and Grocott staining showed numerous organisms suggestive of Histoplasma within macrophages. Thoracic radiographs, abdominal ultrasound and routine laboratory testing were unremarkable. Fungal culture of a nodule was negative. PCR of total DNA extracted from the infected tissue and subsequent sequencing confirmed the diagnosis of H. capsulatum var. capsulatum . Surgical excision of the other nodules was performed, and the cat was treated with oral itraconazole 5 mg/kg once daily; 12 weeks after initial consultation, no lesions were visible. No recurrence was observed during an 8 month follow‐up period. Conclusions and clinical importance Histoplasmosis should be included in the differential diagnosis of nodular diseases of cats worldwide.
Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system. (1993)

Recently, we have demonstrated that the tyrosine kinase pp60v-src can undergo cell-free assembly into a heterocomplex with rabbit hsp90 and p50 when the immunoadsorbed protein is incubated with rabbit reticulocyte lysate (Hutchison, K. A., Brott, B. K., De Leon, J. H., Perdew, G. H., Jove, R., and Pratt, W. B. (1992) J. Biol. Chem 267, 2902-2908). Using a baculovirus system to express a high level of human c-Raf serine/threonine kinase in Sf9 insect cells, we show here that immunoadsorbed c-Raf undergoes similar lysate-mediated assembly into a heterocomplex with hsp90 and p50. As with pp60v-src and steroid receptors, binding of c-Raf to hsp90 occurs in an ATP-dependent and K(+)-dependent manner and the resulting heterocomplex is stabilized by molybdate. With a very rapid and gentle procedure of Sf9 cell cytosol preparation and c-Raf immunoadsorption, we show coimmunoadsorption of the insect homologue of hsp90. The same procedures permit detection of a native complex of v-Raf with rat hsp90 and p50 in stably transfected rat 3Y1 fibroblasts, and v-Raf is also assembled into a heterocomplex with rabbit hsp90 and p50 by reticulocyte lysate. Using the 22W mutant of c-Raf in which the NH2-terminal half has been deleted, we show that the catalytic domain of the kinase is sufficient for both formation of the native heterocomplex in mouse NIH 3T3 cells and cell-free reconstitution of the heterocomplex by rabbit reticulocyte lysate. Although the native Raf-heat shock protein heterocomplex is less stable than native pp60v-src and glucocorticoid receptor heterocomplexes, by analogy with these proteins its detection may have important implications regarding the mechanism of Raf trafficking through the cytoplasm.
Adaptive frequency-shaped sliding mode control for narrow-band disturbance rejection (2016)

Narrow-band disturbances will generate vibrations at multiple frequencies and cause significant performance degradation in modern high precision control systems. This paper proposes an adaptive frequency-shaped sliding mode control (AFSSMC) algorithm to deal with such disturbances. The proposed AFSSMC incorporates a peak filter with varying central frequencies to shape the sliding surface and thus provides on-line frequency-dependent control allocation. An extended state observer (ESO) is designed to estimate both the states and the disturbances. The disturbance estimate is utilized to identify the peak frequencies of the disturbance and adaptively tune the peak filter in AFSSMC; the state estimate is utilized to generate the control signal. The evaluation is performed on a simulated hard disk drive, and the effectiveness is validated.
System architecture for partition-tolerant distributed databases (1985)

An overview is presented of an approach to distributed database design which emphasizes high availability in the face of network partitions and other communication failures. This approach is appropriate for applications which require continued operation and can tolerate some loss of integrity of the data. Each site presents its users and application programs with the best possible view of the data which it can, based on those updates which it has received so far. Mutual consistency of replicated copies of data is ensured by using time stamps to establish a known total ordering on all updates issued, and by a mechanism which ensures the same final result regardless of the order in which a site actually receives these updates. A mechanism is proposed, based on alerters and triggers, by which applications can deal with exception conditions which may arise as a consequence of the high-availability architecture. A prototype system which demonstrates this approach is near completion.
Radiotherapy for GIST progressing during or after tyrosine kinase inhibitor therapy: A prospective study (2015)

Responses to radiotherapy were infrequent, but most patients had durable stabilization of the target lesions. GIST patients with soft tissue metastases benefit frequently from radiotherapy.
Differential Optical Spectrometer Based on Critical Angle Dispersion (2021)

We introduce and prove the concept of differential optical spectrometer based on critical angle dispersion. A long waveguide of beveled input and output interfaces is used, where the light to be detected is oriented in the vicinity of waveguide numerical aperture. The incidence angle is swept, and a single detector is used for detection from the other side. Theoretical resolution and resolving power were deduced. The concept was applied to an off-the-shelf ZnSe crystal. Validation is proven by retrieving reference wavelengths of two lasers as well as the absorption spectrum of a reference material.
Alternation of inverse problem and deep learning approaches for phase unwrapping in lens-free microscopy (Conference Presentation) (2020)

Lens-free microscopy aims at recovering sample image from diffraction measurements. The acquisitions are usually processed with an inverse problem approach. Recently, deep learning has been used to further improve phase retrieval results. Here, we propose to alternate iteratively between the two algorithms, to improve the reconstruction results without losing data fidelity. We validated this method for the phase image recovery of floating cells sample at large density acquired by means of lens-free microscopy. This is a challenging case with a lot of phase wrapping artefacts that has never been successfully solved using inverse problem approaches only.
Luteolytic activity of LHRH and [D-Ser(TBU)6, des-Gly-NH2(10)]LHRH ethylamide: a new and physiological approach to contraception in women. (1980)

The administration of five subcutaneous 250-microgram doses of luteinizing hormone-releasing hormone (LHRH) at 4-hour intervals on 1 or 2 consecutive days between days 1 and 9 following the spontaneous LH surge in normal women shortened the luteal phase from 1 to 4 days in 16 out of 17 treatment cycles. Treatment appeared to be more efficient when LHRH was administered on days 6 to 9 after the LH surge as compared with days 1 to 5. In fact, the luteal phase was shortened from 3.3 +/- 0.2 versus 1.4 +/- 0.2 days (P < 0.01) and the serum progesterone level was decreased to 44 +/- 5 versus 71 +/- 6% of control levels (P < 0.01) when the neurohormone was injected late as compared with early in the luteal phase. A similar luteolytic effect has been obtained after intranasal administration of 500 microgram of [D-Ser(TBU)6, des-Gly-NH2(10)]LHRH ethylamide at 0800 and 1700 h on one day between days 4 and 9 following the LH peak. In six women treated with the LHRH analogue during two consecutive cycles, the luteal phase was shortened by 2.6 +/- 0.4 days (range 0.5-4.5 days) and plasma progesterone levels were reduced to 61.3 +/- 9.2% of control. As determined by daily blood sampling for LH, FSH, estradiol, and progesterone, normal cycles occurred immediately after treatment. The present data indicate the luteolytic effect of treatment with LHRH or a LHRH agonistic analogue in normal women and support the interest of such a new and physiological approach for the control of corpus luteum function and menstrual cycle in women.
Treatment of B-cell lymphomas with anti-idiotype antibodies alone and in combination with alpha interferon (1989)

Idiotypes are distinct clonal markers for B-cell lymphomas. Previously we reported the use of anti-idiotype antibodies in the therapy of patients with B-cell malignancies. Because synergy was demonstrated with the addition of alpha interferon to anti-idiotype antibodies in a murine lymphoma model, we performed a clinical trial combining these two agents. Here we provide an update of the original trial of anti-idiotype antibodies alone and report the outcome of the new combination trial. In 16 treatment courses of anti-idiotype antibodies alone there were seven partial responses and one complete response. In 12 courses of combination anti-idiotype antibody and alpha interferon there were two complete responses and seven partial responses. Substantial tumor regressions occurred with minimal toxicity in both trials even in patients refractory to conventional chemotherapy. Tumor specimens obtained at the time of disease progression often contained a preponderance of idiotype-negative lymphoma cells, suggesting that anti-idiotype antibody treatment exerted a strong antitumor effect against antigen-positive cells. Anti-idiotype antibodies have reproducible objective antitumor activity in B-cell lymphoma. The addition of alpha interferon may improve the initial rate of response to this treatment. Strategies that deal effectively with idiotype-negative lymphoma cells should improve the extent and duration of these responses.
Real-Time Digital Chemistry Offshore Transforms Flow Assurance Management (2021)

Abstract Managing asphaltene accumulation in offshore Gulf-of-Mexico wells is a significant challenge. Until recently there was no real-time chemical monitoring that could advise on whether chemical inhibition was making a particular well more, or less, stable. This changed with the development of real-time hardware that directly measures the ratio of asphaltene flowing in the oil. A new generation of that hardware has now been launched which meets all of the Qualification and HSE requirements for deployment on offshore platforms. A microwave resonator was designed to receive fluid at wellhead conditions, i.e., without a reduction in pressure or temperature, and the parameters of that resonator were optimized to maximize microwave intensity for typical oilfield fluids. The microwave circuitry is incorporated in an explosion-proof container with Class 1 Div 2 rated electrical and fluid connections. By combining that resonator with a solenoid that can generate a large magnetic field around a flowline, the resulting device resonates electrons within asphaltene molecules to create a unique signature that is proportional to the total asphaltene count. Estimates of oil-water cut and gas-oil ratio are also obtained as part of the processing and this combination gives the percentage of asphaltene within the oil. The use of this hardware with controlling software and cloud processing creates a unique Internet-of-Things device which can be used to optimize asphaltene-related flow assurance challenges offshore. Pressure testing up to 5ksi and 120C gives the device a working envelope well exceeding typical offshore production hardware requirements. For a fixed fluid, the computation of asphaltene ratio was shown to be independent of applied pressure. Conversely, it was found that in a live well chemical properties of fluids can change over the course of a few hours even when the surface pressure and flow-rates stay the same. In one well, the surface asphaltene percentage within an oil was seen to vary from 0.3% to 3% because of alternating deposition and erosion of an asphaltene layer that had been forming along the ID of production tubing. Over the course of a series of tests in the Middle East, it was observed that those wells with uniform asphaltene percentage were seen as less troublesome to manage compared to wells with a higher deviation. In two Permian fields subject to CO2 flooding, a geographic variation in asphaltene percentage which correlated to the long-term exposure to injected gas was observed. It has long been standard for chemical properties of fluids to be obtained by sending samples to a lab. This paper demonstrates additional value that can be obtained from getting that data in real-time, especially when viewed in the context of an overall chemical management program.
Thrombotic Microangiopathy: Recurrence following Renal Transplant and Response to Plasma Infusion (1982)

Recurrence of thrombotic microangiopathy (TMA) has rarely been reported following renal transplantation. We describe a 24-year-old man who developed irreversible renal failure due to thrombotic microangiopathy. Following renal transplantation, he developed recurrent episodes of microangiopathic hemolysis; during one of these episodes a biopsy revealed the development of thrombotic microangiopathy in the graft. In each of five recurrences to date, plasma infusion, either alone or combined with other forms of therapy, has produced a prompt remission. This is the first report, to our knowledge, of the successful treatment of recurrent TMA in a renal transplant recipient.
Dispersal State of Multiwalled Carbon Nanotubes Elicits Profibrogenic Cellular Responses That Correlate with Fibrogenesis Biomarkers and Fibrosis in the Murine Lung (2011)

We developed a dispersal method for multiwalled carbon nanotubes (MWCNTs) that allows quantitative assessment of dispersion on profibrogenic responses in tissue culture cells and in mouse lung. We demonstrate that the dispersal of as-prepared (AP), purified (PD), and carboxylated (COOH) MWCNTs by bovine serum albumin (BSA) and dipalmitoylphosphatidylcholine (DPPC) influences TGF-β1, PDGF-AA, and IL-1β production in vitro and in vivo. These biomarkers were chosen based on their synergy in promoting fibrogenesis and cellular communication in the epithelial-mesenchymal cell trophic unit in the lung. The effect of dispersal was most noticeable in AP- and PD-MWCNTs, which are more hydrophobic and unstable in aqueous buffers than hydrophilic COOH-MWCNTs. Well-dispersed AP- and PD-MWCNTs were readily taken up by BEAS-2B, THP-1 cells, and alveolar macrophages (AM) and induced more prominent TGF-β1 and IL-1β production in vitro and TGF-β1, IL-1β, and PDGF-AA production in vivo than nondispersed tubes. Moreover, there was good agreement between the profibrogenic responses in vitro and in vivo as well as the ability of dispersed tubes to generate granulomatous inflammation and fibrosis in airways. Tube dispersal also elicited more robust IL-1β production in THP-1 cells. While COOH-MWCNTs were poorly taken up in BEAS-2B and induced little TGF-β1 production, they were bioprocessed by AM and induced less prominent collagen deposition at sites of nongranulomatous inflammation in the alveolar region. Taken together, these results indicate that the dispersal state of MWCNTs affects profibrogenic cellular responses that correlate with the extent of pulmonary fibrosis and are of potential use to predict pulmonary toxicity.
Multifilamentary V&lt;inf&gt;3&lt;/inf&gt;Ga wire: A critical review (1979)

Initial studies of V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Ga conductors formed by the bronze technique coincided with early work on Nb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Sn conductors; however, due to several technological difficulties, emphasis to date has been on commercial production of Nb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Sn composites. The superior critical current density of V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Ga in high magnetic fields (H> 10T), however, favor this conductor in selected applications. Improvements in critical current density have been achieved by using a modified bronze technique whereby the filaments as well as the Cu matrix are alloyed with Ga. Recent studies of the temperature and magnetic field dependence of the critical current density as well as stress effects, and third element additions are presented. Superconducting applications which may benefit from the use of V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Ga wire will be emphasized.
Electrodeposited Cu2ZnSnSe4 thin film solar cell with 7% power conversion efficiency (2013)

ABSTRACT High performance Cu 2 ZnSnSe 4 (CZTSe) photovoltaic materials were synthesized by electrodeposition of metal stack precursors followed by selenization. A champion solar cell with 7.0% efficiency is demonstrated. This is the highest efficiency among all of the CZTSe solar cells prepared from electrodeposited metallic precursors reported to‐date. Device parameters are discussed from the perspective of material microstructure and composition in order to improve performance. In addition, a high performance electrodeposited CZTS (S only) solar cell was demonstrated and its device characteristics were compared against the CZTSe (Se only) cell. Using secondary ion mass spectrometry for the analysis of the chemical composition of the absorber layer, a higher concentration of oxygen in the electrodeposited absorber is thought to be the root cause of the lower performance of the electrodeposited CZTS or CZTSe solar cells with respect to a solar cell fabricated by evaporation. The grain boundary areas of Sn‐rich composition are thought to be responsible for the lower shunt resistance commonly observed in CZTSe devices. We measured the longest minority carrier lifetime of 18 ns among all reported kesterite devices. This work builds a good baseline for obtaining higher efficiency earth‐abundant solar cells, while it highlights electrodepositon as a low cost and feasible method for earth‐abundant thin film solar cell fabrication. Copyright © 2013 John Wiley &amp; Sons, Ltd.
Z-Pinch Driven Inertial Confinement Fusion Target Physics Research at Sandia National Laboratories (1998)

Three hohlraum concepts are being pursued at Sandia National Laboratories (SNL) to investigate the possibility of using pulsed power driven magnetic implosions (z-pinches) to drive high gain targets capable of yields in the range of 200-1000 MJ. This research is being conducted on SNL'S.Z facility that is capable of driving peak currents of 20 MA in z-pinch loads producing implosion velocities as high as 7.5X 107 cm/s, x-ray energies approaching 2 MJ, and x-ray powers exceeding 200 TW. This paper will discuss each of these hohlraum concepts and will overview the experiments that have been conducted on these systems to date.
A virtual translation technique to improve current regulator for salient-pole AC machines (2004)

This paper presents a synchronous frame current regulator for salient-pole AC machines, which is insensitive to both parameters and synchronous frequencies. The transformation from stationary to synchronous frame is known to produce a frame-dependent cross-coupling term, which results in degradation in current response at high speeds and is represented as an asymmetric pole in the complex vector form of such systems. The asymmetric pole close to right half plane (RHP) in the complex vector s-domain cannot be perfectly canceled by parameter-based design of PI controllers due to parameter variation. Complex vector design synchronous frame PI current regulator with a virtually translated asymmetric pole is shown in this paper to reduce the parameter sensitivity and to improve disturbance rejection. The current regulator with the virtually translated pole have been analyzed in complex vector form for nonsalient-pole AC machine and in scalar form for salient-pole AC machines. It has been shown to yield comparable performances in both cases. This paper includes experimental verification of the performance of the proposed current regulator for an IPMSM.
Reactions of C5H3+ and C5H5+ ions with acetylene and diacetylene (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of C5H3+ and C5H5+ ions with acetylene and diacetyleneFeza Ozturk, Mehdi Moini, Fred W. Brill, John R. Eyler, Thomas J. Buckley, Sharon G. Lias, and Pierre J. AusloosCite this: J. Phys. Chem. 1989, 93, 10, 4038–4044Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://pubs.acs.org/doi/10.1021/j100347a035https://doi.org/10.1021/j100347a035research-articleACS PublicationsRequest reuse permissionsArticle Views135Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts