gebhart/patrepeval huggingface dataset:
Assembly of a functional 3D primary cardiac construct using magnetic levitation (2016)

Easily assembled organotypic co-cultures have long been sought in medical research. <em>In vitro</em> tissue constructs with faithful representation of <em>in vivo</em> tissue characteristics are highly desirable for screening and characteristic assessment of a variety of tissue types. Cardiac tissue analogs are particularly sought after due to the phenotypic degradation and difficulty of culture of primary cardiac myocytes. This study utilized magnetic nanoparticles and primary cardiac myocytes in order to levitate and culture multicellular cardiac aggregates (MCAs). Cells were isolated from 2 day old Sprague Dawley rat hearts and subsequently two groups were incubated with either C<sub>1</sub>: 33 µL nanoshell/million cells or C<sub>2</sub>: 50 µL nanoshell/million cells. Varying numbers of cells for each concentration were cultured in a magnetic field in a 24 well plate and observed over a period of 12 days. Constructs generally formed spherical structures. Masson’s trichrome staining of a construct shows the presence of extracellular matrix protein, indicating the presence of functional fibroblasts. Many constructs exhibited noticeable contraction after 4 days of culture and continued contracting noticeably past day 9 of culture. Noticeable contractility indicates the presence of functional primary cardiac myocytes in culture. Phenotypic conservation of cardiac cells was ascertained using IHC staining by α<strong>-</strong>actinin and collagen. CD31 and fibrinogen were probed in order to assess localization of fibroblasts and endothelial cells. The study verifies a protocol for the use of magnetic levitation in order to rapidly assemble 3D cardiac like tissue with phenotypic and functional stability.
Incremental stock time series data delivery and visualization (2005)

SB-Tree is a binary tree data structure proposed to represent time series according to the importance of data points. Its use in stock data management is distinguished by preserving the critical data points' attribute values, retrieving time series data according to the importance of data points and facilitating multi-resolution time series retrieval. As new stock data are available continuously, an effective updating mechanism for SB-Tree is needed. In this paper, a study of different updating approaches is reported. Three families of updating methods are proposed. They are periodic rebuild, batch update and point-by-point update. Their efficiency, effectiveness and characteristics are compared and reported.
Neutralizing Polyclonal IgG Present during Acute Infection Prevents Rapid Disease Onset in Simian-Human Immunodeficiency Virus SHIV SF162P3 -Infected Infant Rhesus Macaques (2013)

Simian-human immunodeficiency virus (SHIV) models for human immunodeficiency virus (HIV) infection have been widely used in passive studies with HIV neutralizing antibodies (NAbs) to test for protection against infection. However, because SHIV-infected adult macaques often rapidly control plasma viremia and any resulting pathogenesis is minor, the model has been unsuitable for studying the impact of antibodies on pathogenesis in infected animals. We found that SHIVSF162P3 infection in 1-month-old rhesus macaques not only results in high persistent plasma viremia but also leads to very rapid disease progression within 12 to 16 weeks. In this model, passive transfer of high doses of neutralizing IgG (SHIVIG) prevents infection. Here, we show that at lower doses, SHIVIG reduces both plasma and peripheral blood mononuclear cell (PBMC)-associated viremia and mitigates pathogenesis in infected animals. Moreover, production of endogenous NAbs correlated with lower set-point viremia and 100% survival of infected animals. New SHIV models are needed to investigate whether passively transferred antibodies or antibodies elicited by vaccination that fall short of providing sterilizing immunity impact disease progression or influence immune responses. The 1-month-old rhesus macaque SHIV model of infection provides a new tool to investigate the effects of antibodies on viral replication and clearance, mechanisms of B cell maintenance, and the induction of adaptive immunity in disease progression.
Deterioration of polyethylene exposed to water containing chlorine dioxide : Testing methods, antioxidant consumption, and polymer degradation (2014)

Deterioration of polyethylene exposed to water containing chlorine dioxide : Testing methods, antioxidant consumption, and polymer degradation
Pultruded fiber reinforced blocked polyurethane (PU) composites. II. Processing variables and dynamic mechanical properties (1992)

Abstract Unidirectional fiber reinforced blocked polyurethane (PU) composites have been prepared by the pultrusion process. The effects of processing variables on the mechanical properties and dynamic mechanical properties of fiber reinforced PU composites by pultrusion have been studied. The processing variables investigated included pulling rate (in‐line speed), die temperature, postcure time and temperature, and filler type and content. The dynamic mechanical properties of the composites produced by the process were studied utilizing dynamic mechanical spectrometer. Results show that the composites possessed various optimum pulling rates at different die temperatures. From the DSC data analysis, swelling ratio, and mechanical properties, the optimum die temperature was determined. It was found that the mechanical properties increase with filler content for various types of filler. The increasing of mechanical properties depends on the optimum postcure temperature and time. However, the properties decreased for longer postcure times since the composite materials were degraded. The glass‐transition temperature ( T g ) increased slightly and the damping peak (tan δ) was broadened due to fiber reinforcement. The dynamic mechanical moduli ( G′, G ″) of pultruded PU composites are apparently higher than those of the matrices. The moduli ( G′, G ″) increase with increasing fiber and filler content, and the damping peak becomes broad. Effect of postcuring on the degree of crosslinking, T g , and dynamic modulus will be discussed.
Performance modelling and comparisons of global shared buffer management policies in a cluster environment (1994)

Clustering multiple computing nodes has become increasingly popular for reasons of capacity, availability and cost. One approach to clustering is the data sharing approach where a number of loosely coupled nodes share a common database. In this environment, a global shared buffer can be introduced to alleviate the multisystem invalidation effect either as a disk cache or shared intermediate memory. We develop an analytic model to evaluate different shared buffer management policies (SBMPs) which differ in their choice of data granules to be put into the shared buffer. The methodology analyzes all policies using a uniform framework by decomposing the input stream to the shared buffer into multiple (three) component streams based on their effects on the dependency between the private and shared buffer contents. This approach simplifies the problem of analyzing different SBMPs into 1) estimating the rate of each component stream, and 2) evaluating the impact of dependency on each type of component stream and hence the shared buffer hit probability. A detailed simulation model is also developed to validate the analytic model. We also illustrate how the analytic buffer model can be integrated with other system submodels to examine trade-offs between the SBMPs and to estimate optimal shared buffer allocations from a cost-performance point of view.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Investigation of Spall Repair Materials for Concrete Pavement (2006)

This project investigated the properties and performance of the products used for spall repair of concrete pavement. A survey of Texas Department of Transportation (TxDOT) maintenance engineers produced a roster of 10 repair materials currently in use in the state. After identifying the key characteristics of a successful repair material, a laboratory testing program was developed to evaluate the properties of the repair materials. These materials were tested for strength, compatibility, and bond to quantify their characteristics relative to those products known to work well. To correlate laboratory data to field data, researchers conducted performance surveys including field core tests, and the field placement of products was performed on a test section. Researchers made recommendations regarding properties, which best predict the success of material and testing procedures to determine these properties. The results of this project will then be used to develop a set of guidelines for the selection of repair materials and the repair procedures to be used by TxDOT engineers to yield the best performance of repaired pavement.
tunable Diode-laser Photoacoustic spectroscopy (2009)

.Photoacoustic spectroscopy [1] is an optical absorption spectroscopy whereby the absorbed optical power is detected indirectly by sensing the thermal excitation and expansion of the sample using microphones or other mechanical displacement sensors. For trace-gassensing, specificity is achieved by tuning the optical excitation source to the narrow band absorption lines of the gas of interest. The accessibility of photoacoustic spectroscopy has improved due to the availability of inexpensive tunable diode-laser sources developed for telecommunications applications and continued innovation in semiconductor active materials [2], [3] is opening new spectral windows for detecting a wider variety of gasses. Photoacoustic detection of optical absorption has favorable scaling properties for miniaturization [4] and miniature photoacoustic cells have been investigated [5] along with compact resonant quartz tuning fork detectors [6]. We are working to develop a compact and robust photoacoustic spectroscopy system with the aim of performing gas analysis in harsh environments. Initial experiments have focused on evaluating photoacoustic sensor architectures and laser diode characterization. FIGURE 1: Schematic representation of a photoacoustic sensor using a quartz tuning fork. Wavelength modulation of the laser diode at 1/2 the resonant frequency of the tuning fork results in optical absorption and thermal excitation at the tuning fork’s resonant frequency.
<title>Effect of monoacrylates on electro-optical properties of light-scattering LCDs</title> (1997)

Electro-optical properties for light scattering liquid crystal displays (LCDs) prepared by using liquid crystalline monoacrylate, phenoxyl monoacrylate and alkyl monoacrylate as a component of monomer shave been investigated. The properties strongly depend on the chemical structure of monoacrylate. The liquid crystalline monoacrylate has effects to reduce the driving voltage and the hysteresis. The effect of the terminal group and the number of core-ring in the liquid crystalline monoacrylate on the driving voltage and the hysteresis is discussed. A memory phenomenon observed at low temperature is influenced by the chemical structure and the content of monoacrylate. The temperature dependence of the driving voltage and the hysteresis for the light scattering LCDs is discussed. Based on these result, a light scattering LCD with low driving voltage, small hysteresis and small temperature dependence has been achieved.
A4T Mutation in the <i>SOD1</i> Gene Causing Familial Amyotrophic Lateral Sclerosis (2003)

We report the clinical and laboratory findings in the largest kindred so far recorded with familial amyotrophic lateral sclerosis due to an A4T mutation in the SOD1 gene. The age of onset ranged from 32 to 60 years, with a mean of 46 years. Weakness in the legs was the most frequent early symptom and there was a predominance of lower motor neuron signs. The mean time from onset of symptoms to death was 14 months. One man with onset at the age of 37 has shown a slowly developing form and is currently alive 76 months after diagnosis (October 2002), although severely affected. The A4T mutation, with one exception, was of similar severity to the A4V mutation.
Standardization, modularization and platform approaches in the engineer-to-order business — Review and outlook (2016)

Standardization, modularization and platforms (S/M/P) are approaches used by industrial companies to cope with complexity of technical products and systems. Despite a long history in product business S/M/P are considered as a fairly recent idea in engineer-to-order (ETO) business. They are applied with varying degrees of success in this business due to a number of challenges. This contribution describes the development of S/M/P from their beginnings in product business to their application in the ETO business. It provides a selection of relevant literature and studies on S/M/P that reflects the current state of research in the ETO business. The contribution also identifies challenges regarding the implementation of S/M/P among ETO companies. The evaluation of cost and benefit of S/M/P approaches, the integration of modules to systems, the definition of module design criteria, the definition of S/M/P specific key performance indicators as well as the scarce methodological support for implementing S/M/P have been identified as main hurdles in the ETO business.
3D visualization of optical ray aberration and its broadcasting to smartphones by ray aberration generator (2017)

The ray formalism is critical to understanding light propagation, yet current pedagogy relies on inadequate 2D representations. We present a system in which real light rays are visualized through an optical system by using a collimated laser bundle of light and a fog chamber. Implementation for remote and immersive access is enabled by leveraging a commercially available 3D viewer and gesture-based remote controlling of the tool via bi-directional communication over the Internet.
Manganese Doped Fluorescent Paramagnetic Nanocrystals for Dual‐Modal Imaging (2014)

In this work, dual-modal (fluorescence and magnetic resonance) imaging capabilities of water-soluble, low-toxicity, monodisperse Mn-doped ZnSe nanocrystals (NCs) with a size (6.5 nm) below the optimum kidney cutoff limit (10 nm) are reported. Synthesizing Mn-doped ZnSe NCs with varying Mn(2+) concentrations, a systematic investigation of the optical properties of these NCs by using photoluminescence (PL) and time resolved fluorescence are demonstrated. The elemental properties of these NCs using X-ray photoelectron spectroscopy and inductive coupled plasma-mass spectroscopy confirming Mn(2+) doping is confined to the core of these NCs are also presented. It is observed that with increasing Mn(2+) concentration the PL intensity first increases, reaching a maximum at Mn(2+) concentration of 3.2 at% (achieving a PL quantum yield (QY) of 37%), after which it starts to decrease. Here, this high-efficiency sample is demonstrated for applications in dual-modal imaging. These NCs are further made water-soluble by ligand exchange using 3-mercaptopropionic acid, preserving their PL QY as high as 18%. At the same time, these NCs exhibit high relaxivity (≈2.95 mM(-1) s(-1)) to obtain MR contrast at 25 °C, 3 T. Therefore, the Mn(2+) doping in these water-soluble Cd-free NCs are sufficient to produce contrast for both fluorescence and magnetic resonance imaging techniques.
Imine prototropy: synthetic consequences in the generation of metalloenamines (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImine prototropy: synthetic consequences in the generation of metalloenaminesPaul A. Wender and John M. SchausCite this: J. Org. Chem. 1978, 43, 4, 782–784Publication Date (Print):February 1, 1978Publication History Published online1 May 2002Published inissue 1 February 1978https://pubs.acs.org/doi/10.1021/jo00398a076https://doi.org/10.1021/jo00398a076research-articleACS PublicationsRequest reuse permissionsArticle Views147Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chemical interaction of polyphosphoric acid with titanium and its effect on human bone marrow derived mesenchymal stem cell behavior (2007)

The aim of this study was to evaluate the effect of treating titanium (Ti) with polyphosphoric acid on the attachment and proliferation of human bone marrow derived mesenchymal stem cells (hBMSCs). Cleaned Ti disks were immersed into three different concentrations of polyphosphoric acid solution (0.1, 1, and 10 wt %) and 10 wt % orthophosphoric acid solution for 24 h at 37 degrees C. Ti immersed in distilled water for 24 h at 37 degrees C served as control. The level of polyphosphoric acid that interacted with the Ti surface was determined by measuring the surface P/Ti ratio (atom%/atom%) using X-ray photoelectron spectroscopy. Degrees of cell attachment (1, 3, 5 h after cell seed) and proliferation (1, 3, 5, and 7 days after cell seed) on each treated Ti disk were evaluated by MTS assay. The mean surface P/Ti ratios increased in a polyphosphoric acid concentration dependent manner. A significantly higher cell attachment was found on Ti treated with polyphosphoric acid in contrast to untreated Ti (control) for all three culture periods. MTS assay also revealed that cell proliferation levels significantly increased following a polyphosphoric acid dose dependency. Ti surface treatment with orthophosphoric acid did not influence the cell attachment and proliferation. It was concluded that polyphosphoric acid treatment of Ti enhanced the attachment and proliferation of hBMSCs.
Methods for mapping mechanisms to developable surfaces (2021)

Planar and spherical mechanisms can be mapped to regular cylindrical and circular conical developable surfaces using cyclic quadrilaterals. The link lengths and link angles can be used in equations to calculate the circumcircle of a cyclic quadrilateral to find the radius or cone angle of a developable surface. Two other numerical and graphical methods to map mechanisms to these surfaces are discussed and expanded. Useful properties of developable mechanisms are also identified using cyclic quadrilaterals. While Grashof mechanisms can be mapped to developable surfaces in either their open or crossed configurations, the only way to map a non-Grashof mechanism to a cylindrical or conical surface is in its open configuration. Extramobile and intramobile behaviour can be predicted based the cyclic quadrilateral's position within the circumcircle and the mechanism's grounded link. The possible configurations are tabulated and analysed.
A Robust and Scalable Polydopamine/Bacterial Nanocellulose Hybrid Membrane for Efficient Wastewater Treatment (2019)

Toxic heavy metal ions and organic pollutants are significant concerns in wastewater treatment. Here, we demonstrate a novel membrane composed of polydopamine (PDA) particles and bacterial nanocellulose (BNC), which can efficiently remove a variety of metal ions and organic dyes from contaminated water. The biocompatible and biodegradable PDA/BNC membrane is synthesized by in situ incorporation of PDA particles into BNC matrix during its bacteria-mediated growth. We show that the PDA/BNC membrane can effectively remove heavy metal ions such as lead and cadmium, and organic dyes as surrogate markers of organic pollutants such as rhodamine 6G (R6G), methylene blue (MB), and methyl orange (MO). The removal efficiencies of contaminants were tested separately or simultaneously via simple filtration at pH values ranging from 4 to 7. Furthermore, after simple washing with regeneration agents, the membrane can be reused multiple times without compromising its contaminant sorption ability and mechanical integrity. The new water treatment membrane introduced here is easy to fabricate, highly scalable, chemically stable, mechanically robust, and reusable, making it highly attractive for wastewater treatment.
Flame Synthesis of C-Doped TiO2 Nanopowders for Dye Sensitized Solar Cells (2011)

Extended abstract of a paper presented at Microscopy and Microanalysis 2011 in Nashville, Tennessee, USA, August 7–August 11, 2011.
Glow Discharge Formation over Water Surface at Saturated Water Vapor Pressure and Its Application to Wastewater Treatment (2006)

With the aim of wastewater treatment using the active reaction of OH radicals generated in gas discharges, DC, low frequency (LF, 100 kHz) and RF (13.56 MHz) glow discharges were generated over the water surface at saturated water vapor pressure. Low-pressure glow discharge over the water surface has an advantage of uniform OH radical production near the water surface. A very stable and uniform glow discharge was obtained with an RF power source, whereas the discharges obtained with the DC and LF power sources were sometimes localized. The effective OH radical production was confirmed from the strong optical emission of OH(A 2 Σ + –X 2 Π) near the water surface. The OH(A 2 Σ + –X 2 Π) emission intensity near the water surface increased almost linearly with an increase in discharge power. N , N -Dimethyl- p -nitrosoaniline (RNO) solution as a persistent test pollutant was treated by RF glow discharge over the water surface. We confirmed that the RNO solution was certainly decolorized by OH radicals generated in the RF glow discharge. It was found that the degradation of target compounds by OH radicals was concentrated near the water surface in the solution because very slow diffusion of target compounds limited the reaction rate.
Automating Best Practices: The Challenge of Process Enactment (1994)

ABSTRACT Process Enactment, or Workflow Management as it is sometimes called, provides a new technology approach which captures a well‐defined, optimized process and encodes it in an executable form. The encoded process is then enacted, providing for automated execution of tasks and activities and the controlled management of all information and data associated with the process. Enactment can be expected to influence both the way we do business and solutions we develop for customers. This paper focuses on the many challenges of process enactment, from both a technical and a cultural perspective. Also discussed will be a pilot project that has provided a test bed for demonstration and evaluation of enactment in our systems engineering environment.