gebhart/patrepeval huggingface dataset:
Aerodynamic Optimization Design of Vaned Diffusers for the 100 kW Micro Gas Turbine’s Centrifugal Compressor (2008)

In this paper the design optimization of vaned diffuser for the 100kW microturbine’s centrifugal compressor is carried out. The forward-loaded and the conventional airfoil diffusers are respectively redesigned based on the surrogate model and the three dimensional viscous flow analyses. The objective of the optimization is to redesign the diffuser that assures, for a given operating condition of the centrifugal impeller, the stage isentropic efficiency to be highest. Using the surrogate model the optimization process is accelerated and the 3D flow analysis’s application to the practical engineering design is efficiently realized. To validate the optimization result, the compressor stage performance test is performed on a high speed centrifugal compressor test rig with one original diffuser and its redesigned, respectively.
Paper 60: Arthroscopic Treatment of Anterolateral Soft Tissue Impingement of the Ankle: Is This an Effective Treatment in Patients Under 15 Years Old? (2012)

Inversion injuries of the ankle are common in children and adolescents. Although the vast majority of these injuries are resolved uneventfully, some young patients develop chronic pain, swelling and giving-way aggravated by activity. The aim of this retrospective study was to evaluate the results of patients less than 15 years old treated with arthroscopic debridement of soft tissue impingement of the ankle.
Formal Network Models and Their Application to Firewall Policies (UPF-Firewall) (2017)

We present a formal model of network protocols and their application to modeling firewall policies. The formalization is based on the Unified Policy Framework (UPF). The formalization was originally developed with for generating test cases for testing the security configuration actual firewall and router (middle-boxes) using HOL-TestGen. Our work focuses on modeling application level protocols on top of tcp/ip.
Actin polymerization‐enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP (2015)

Hippo signaling pathway consists of conserved serine/threonine kinases to maintain optimal organ sizes. Studies have demonstrated that fragmentation of murine ovaries increases actin polymerization and disrupts Hippo signaling, leading to nuclear translocation of Hippo signaling effector Yes-associated protein (YAP) in ovarian follicles and follicle growth. For patients with polycystic ovarian syndrome showing follicle arrest, ovarian wedge resection and laser drilling promote follicle growth. Because these damaging procedures likely involve actin polymerization, we tested whether actin polymerization-promoting drugs could promote YAP translocation and stimulate follicle growth. Treatment of murine ovaries with μM Jasplakinolide (JASP), an actin polymerization-promoting cyclic peptide, or sphingosine-1-phosphate (S1P), a follicular fluid constituent known to promote actin polymerization, increased the conversion of globular actin to the filamentous form, followed by increased nuclear YAP and expression of downstream connective tissue growth factor (CCN2). After short-term treatments with JASP or S1P, in vitro cultured and in vivo grafted ovaries showed follicle growth. Furthermore, induction of constitutively active YAP in ovarian grafts of transgenic mice enhanced follicle development, whereas treatment of human ovarian cortices with JASP or S1P increased CCN2 expression. Thus, JASP and S1P stimulate follicle growth and are potential therapeutic agents for treating polycystic ovarian syndrome and other ovarian disorders.
Combination chemotherapy with adriamycin, cyclophosphamide, vincristine, methotrexate, etoposide and dexamethasone (ACOMED) followed by involved field radiotherapy induces high remission rates and durable long-term survival in patients with aggressive malignant non-Hodgkin's lymphomas: long-term follow-up of a pilot study (2005)

The aim of the present study was to evaluate the feasibility and efficacy of the intensified induction chemotherapy regimen ACOMED for patients with aggressive non-Hodgkin's lymphoma (NHL). Untreated adult patients with aggressive NHL, presenting with Ann Arbour stage II-IV disease or stage I with bulky disease, and with at least one of the following risk factors: age > 60 years, advanced disease, elevated serum lactate dehydrogenase level, Eastern Cooperative Oncology Group (ECOG) performance status >or= 2, presence of extranodal sites of disease and bulky disease, were treated with the ACOMED regimen consisting of 4-6 cycles of adriamycin 25 mg/m(2) i.v. on days 4-5, cyclophosphamide 250 mg/m(2) i.v. on days 1-5, vincristine 2 mg i.v. absolute on day 1, methotrexate 500 mg/m(2) i.v. on day 1 with leucovorin-rescue after 24 h 30 mg/m(2) i.v. and 3 x 15 mg p.o., etoposide 100 mg/m(2) i.v. on days 3-5, dexamethasone 10 mg/m(2) p.o. on days 1-5 and granulocyte colony-stimulating factor support, repeated on day 21. Twenty-two patients were treated within this study at a single center. After 4-6 cycles of ACOMED followed by additional involved field radiotherapy in 18 patients, the complete and overall response rates were 86% (19 of 22 patients) and 95% (21 of 22 patients), respectively. After a median observation time of 10 years and 2 months, 16/22 (73%) patients are alive in continuous complete response without evidence of any late toxicities. ACOMED followed by involved field radiation presents a highly effective regimen for remission induction and long-term survival in patients with aggressive NHL, and merits further investigation.
Review of: "Evaluating Human Mutation Databases for ‘Treatability’ Using Personalized Antisense Oligonucleotides" (2022)

This survey/review of a bottoms up approach to identifying rare genetic diseases that are potentially treatable with ASO technologies is quite valuable to the antisense community and should be published without further revision.
Efficient coupling of high-intensity subpicosecond laser pulses into dilute solid targets (1992)

We have demonstrated that high-intensity sub-picosecond laser pulses can be efficiently absorbed by a dilute solid material. We have measured laser reflectivities as low as 10% from certain targets, in contrast to the 90% reflectivity observed from flat solid surfaces. The hot plasmas generated on dilute solids exhibit greatly increased x-ray emission due to the enhanced laser absorption. Laser-to-x-ray conversion efficiency greater than 1% have been observed for x-ray energies above 1keV.
Phenotypic and Genotypic Changes in a New Clone Complex of Neisseria meningitidis Causing Disease in the Netherlands, 1958-1990 (1994)

To characterize the phenotypic and genotypic changes that occurred in a new clone lineage of Neisseria meningitidis (lineage III) in the Netherlands, the electrophoretic type (ET) was determined for 79 serogroup B isolates of serotype 4 or subtype P1.4 (or both) obtained between 1958 and 1990 from patients with systemic meningococcal disease. Thirty-five previously described isolates were also included. After its appearance in 1980, lineage III started homogeneously with regard to both genotype (ET-24) and phenotype (B:4:P1.4). After 1984, other clones appeared in the lineage, and the various clones acquired other serotypes (serotypes 14 and 15) and subtypes (P1.2, P1.7, and P1.12), indicating frequent exchange of genetic material between clones. These results indicate that basing a serogroup B vaccine on outer membrane components from a single strain is not a valid strategy for the prevention of meningococcal disease.
Reply (2015)

Beetham Eye Institute, Joslin Diabetes Center, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts None of the authors have any financial/conflicting interests to disclose.
Parallel Cholesky Factorization for Banded Matrices using OpenMP Tasks (2023)

Cholesky factorization is a widely used method for solving linear systems involving symmetric, positive-definite matrices, and can be an attractive choice in applications where a high degree of numerical stability is needed. One such application is numerical optimization, where direct methods for solving linear systems are widely used and often a significant performance bottleneck. An example where this is the case, and the specific type of optimization problem motivating this work, is radiation therapy treatment planning, where numerical optimization is used to create individual treatment plans for patients. To address this bottleneck, we propose a task-based multi-threaded method for Cholesky factorization of banded matrices with medium-sized bands. We implement our algorithm using OpenMP tasks and compare our performance with state-of-the-art libraries such as Intel MKL. Our performance measurements show a performance that is on par or better than Intel MKL (up to ~26%) for a wide range of matrix bandwidths on two different Intel CPU systems.
Sequential Observation of Electroless Copper Deposition via Noncontact Atomic Force Microscopy (1998)

The dynamic morphological evolution of electroless copper deposition on palladium‐activated high density physical vapor deposited TiN and oxide passivated TiN has been studied via noncontact atomic force microscopy. With precise control of the vibrational amplitude and resonant frequency of the cantilever probe, submicrometer length scale images were sequentially acquired for the deposition process. The different substrates are associated with two different growth schemes, although in both cases, lateral growth across the substrate dominated over vertical growth during the initial nucleation stage, which was followed by three‐dimensional growth. In the case of TiN, simultaneous nucleation of Cu nodules on Pd nucleation catalyst and TiN grains was observed in the initial nucleation stages. However, only deposition of Cu grains on Pd catalyst was found in the case of oxide passivated TiN. Nevertheless, both growth schemes eventually lead to the formation of continuous Cu films.
Correction of Geometric Influence in Permittivity Determination (2018)

Determination of relative permittivity of dielectric materials is generally done with a rather low accuracy, in the order of several percent. This is in a sharp contrast to the accuracy of measurements of the dissipation factor, both usually being determined in the same measurement. A common understanding for the inferior accuracy in permittivity measurements is the effects of electrode edges. However, further studies indicate that geometric effects, arising from electrode shielding box, guard ring, electrode supporting materials, etc., also influence the accuracy significantly if the responding voltage present at the measuring electrode is non-negligible. With help of the Finite Element Method (FEM), geometric correction factors are estimated from an electrode model to increase the accuracy. This study is specially focused on the application of contact-free electrode arrangement using the air reference method. In this paper, a few examples of how geometric influences affect results are presented as well as a comparison of experimental results. From these insights, we discuss how to minimize and compensate the geometric effects.
Faktoren, die die gesundheitsassoziierte Lebensqualität und das Symptom Depression bei Patienten nach Lebertransplantation beeinflussen: Eine Querschnittsstudie des Transplantationszentrums Heidelberg (2012)

Einleitung: Aufgrund der sehr guten Langzeitergebnisse nach orthotoper Lebertransplantation (OLT) gewinnt der Aspekt der gesundheitsassoziierten Lebensqualität (HRQOL) und der beruflichen Wiedereingliederung immer mehr an Bedeutung.
Overview of the AFRL's Demonstration and Science Experiments (DSX) Program (2006)

Abstract : The Air Force Research Laboratory (AFRL) Space Vehicles Directorate has developed the Demonstration and Science Experiments (DSX) mission to research technologies needed to significantly advance Department of Defense (DoD) capability to operate spacecraft in the harsh radiation environment of medium-earth orbits (MEO). The ability to operate effectively in the MEO environment significantly increases the DoD's capability to field space systems that provide persistent global targeting-grade space surveillance, high-speed satellite-based communication, lower-cost GPS navigation, and protection from space weather on a responsive satellite platform. The three DSX physics-based research areas are: 1. Wave Particle Interaction Experiment (WPIx): Researching the physics of very-low-frequency (VLF) transmissions in the magnetosphere and characterizing the feasibility of natural and man-made VLF waves to reduce space radiation; 2. Space Weather Experiment (SWx): Characterizing and modeling the space radiation environment in MEO, an orbital regime attractive for future DoD and commercial missions; 3. Space Environmental Effects (SFx): Researching and characterizing the space weather effects on spacecraft electronics and materials. DSX uses a modular design that allows for launch either as a primary satellite on a conventional launcher, such as a Minotaur, or as a secondary payload on a larger rocket, such as the Evolved Expendable Launch Vehicle (EELV). Another key feature is the use of a dedicated payload computer, which unburdens the avionics of the need to conform to custom payload data interfaces, enabling the rapid procurement of a standard spacecraft bus. An overview of the DSX science experiments, payload design, spacecraft subsystems, and engineering approach will be described.
Distribution of socioeconomic status and its association with type 2 diabetes mellitus in China rural area: Henan Rural Cohort study (2021)

Abstract Background The measures of socioeconomic status (SES) differed across divergent researches and rare of them focused on rural population. This research, thus, presented a novel measure of SES among rural population and then estimated its association with type 2 diabetes mellitus (T2DM). Methods All participants were farmer and enrolled from the Henan Rural Cohort study. SES of individual was assessed by SES-score, a composite index derived from three SES-related indicators (education level, average monthly income, and marital status). Binary logistic regression was employed to examine the independent association between SES-score and T2DM as well as the combined effects of SES and age on T2DM. To detect the gender differences, all analyses were stratified by gender. Results Among 39259 rural participants, the means (SDs) SES-score of total population, men, and women were 3.47 (1.54), 3.72 (1.49), and 3.31 (1.57), respectively. The SES-score decreased with age and men always had a higher score than women. The prevalence of T2DM decreased with increasing SES-score among women (14.87–4.47%, P trend &lt;0.001), while an inverse trend was observed among men (6.59–9.87%, P trend &lt;0.001). Adjusted ORs (95%CIs) for prevalent T2DM, per unit increase, were 1.07 (1.03, 1.12) in men and 0.96 (0.93, 0.99) in women. Old men with high SES and old women with low SES were vulnerable to T2DM. Conclusions Men had a higher SES-score than women in rural areas, and this gap increased with age. The association between SES and T2DM was differed by gender. Trail Registration: The Henan Rural Cohort Study has been registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). Date of registration: 06 July, 2015. http://www.chictr.org.cn/showproj.aspx?proj=11375
Regulation of Glycerol Catabolism in Klebsiella aerogenes (1974)

The utilization of glycerol as a carbon source for growth by Klebsiella aerogenes, strain 2103, involves separate aerobic (sn-glycerol-3-phosphate or G3P) and anaerobic (dihydroxyacetone or DHA) pathways of catabolism. Enzyme and transport activities of the aerobic pathway are elevated in cells grown under oxygenated conditions on glycerol or G3P. Anaerobic growth on G3P as carbon source requires the presence of an exogenous hydrogen acceptor such as fumarate; cells thus grown also are highly induced in the G3P pathway. Anaerobic growth on glycerol requires no exogenous hydrogen acceptors; cells thus grown are highly induced in the DHA pathway but almost uninduced in the G3P pathway and the addition of fumarate electron acceptors has no effect on the relative levels of the two pathways. When both glycerol and G3P are provided anaerobically with fumarate, the DHA pathway is still preferentially induced, which probably accounts for the exclusive utilization of glycerol until its exhaustion. These observations suggest the presence of a regulatory control of G3P pathway imposed by the operation of the DHA pathway.
A CMOS Charge-Domain Global Shutter Pixel Characterization System (2021)

This paper presents a photosensitive active pixel readout test chip, targeted for use in the electro-optical characterization of various charge-domain global shutter test pixels. The proposed system employs a scalable 256x256 resolution pixel array and a column-parallel analog signal processing chain. For the purpose of accurate spatial and temporal noise measurements, a low-noise column-level PGA, 12-bit ADC with oversampling capabilities, and flexible row-driver control has been introduced. The presented system is designed under a 0.11um 1P4M FSI CMOS process and includes a 7T charge domain test pixel with HDR features. The presented pixel measurement data further supports the validity of the system which is further discussed.
The Molybdenum-Containing Hydroxylases of Quinoline, Isoquinoline, and Quinaldine (2002)

2. BIOCHEMICAL AND GENETIC CHARACTERIZATION 2.1. Bacterial Catabolism of Quinoline, Isoquinoline, and Quinaldine 2.2. Cofactors of Quinoline 2-Oxidoreductase, Isoquinoline 1-Oxidoreductase, and Quinaldine 4-Oxidase 2.3. Catalytic Activities of Quinoline 2-Oxidoreductase, Isoquinoline 1-Oxidoreductase, and Quinaldine 4-Oxidase 2.4. Comparative Sequence Analysis, and Expression Cloning of Genes Encoding Quinoline 2-Oxidoreductase and Isoquinoline 1-Oxidoreductase
Crystal Driven Neutron Source: A New Paradigm for Miniature Neutron Sources (2009)

Neutron interrogation techniques have specific advantages for detection of hidden, shielded, or buried threats over other detection modalities in that neutrons readily penetrate most materials providing backscattered gammas indicative of the elemental composition of the potential threat. Such techniques have broad application to military and homeland security needs. Present neutron sources and interrogation systems are expensive and relatively bulky, thereby making widespread use of this technique impractical. Development of a compact, high intensity crystal driven neutron source is described. The crystal driven neutron source approach has been previously demonstrated using pyroelectric crystals that generate extremely high voltages when thermal cycled [1-4]. Placement of a sharpened needle on the positively polarized surface of the pyroelectric crystal results in sufficient field intensification to field ionize background deuterium molecules in a test chamber, and subsequently accelerate the ions to energies in excess of {approx}100 keV, sufficient for either D-D or D-T fusion reactions with appropriate target materials. Further increase in ion beam current can be achieved through optimization of crystal thermal ramping, ion source and crystal accelerator configuration. The advantage of such a system is the compact size along with elimination of large, high voltage power supplies. A novel implementation discussed incorporates an independently controlled ion source in order to provide pulsed neutron operation having microsecond pulse width.
Compact scanning retarding potential analyzer (2021)

A miniature scanning electrostatic energy analyzer has been developed for measurements of the ion energy distribution in low-pressure plasma discharges. The retarding potential analyzer utilizes four grids to reject the incident electron flux and discriminate the ion energy. It features a compact size of 5-mm diameter and 2.5-mm thickness and uses a simple configuration to mount the grids and provide voltage isolation using high temperature ceramic cement that avoids complicated grid alignment or MEMS fabrication techniques. Mounting on a fast-scanning two-axis probe drive eliminates overheating of the ceramics and subsequent current leakage, which permits insertion into challenging locations and provides profiles of the ion energy in the plasma discharge. Guidelines for the analyzer design for high density operation are discussed, and the performance of the analyzer is shown for measurements in a hollow cathode plume in xenon plasmas.
The Relationship between Retinal Arteriolar and Venular Calibers Is Genetically Mediated, and Each Is Associated with Risk of Cardiovascular Disease (2010)

These results suggest that future gene-mapping studies may identify pleiotropic genetic variants influencing both retinal arteriolar and venular calibers. Genetic variants associated with retinal caliber and (risk factors for) cardiovascular disease should provide new etiologic insights into this complex disease.
Reactionless robots: novels designs and concept studies (2004)

For conventional robots, manipulator motions result in forces and moments on the base to cause undesirable base excitations. The objective of this paper is to systematically analyze the fundamentals of reactionless robots. Based on this analysis, design of two distinct classes of planar robots is proposed. Due to the underlying principle of conservation of angular momentum for these robots, the trajectory planning must satisfy additional constraints, illustrated through computer simulations. Currently, we are fabricating reactionless robots to illustrate the underlying concepts.
Online Behavioral Analysis and Modeling [Guest Editorial] (2016)

Online behavioral analysis and modeling has aroused considerable interest from closely related research fields such as data mining, machine learning, and information retrieval. This special issue provides a forum for researchers in behavior analysis to review pressing needs, discuss challenging research issues, and showcase state-of-the-art research and development in modern Web platforms.
Roof top photovoltaic grid integration: Utility approach (2016)

Because of environmental issues, penetration of solar generation has dramatically increased in recent times. However, due to rise in its penetration, various technical aspects viz. safety, power quality, protection and distribution network planning are to be addressed by the utility. Considering the impact of grid tied roof top photovoltaic system penetration on existing conventional distribution system, the paper elaborates on measures to be taken by utility (power distribution licensee) for successful integration. Field measurements are presented to substantiate the concepts explained.
The Histopathology of Angiographic Chronic Total Coronary Artery Occlusions Ñ Changes in Neovascular Pattern and Intimal Plaque Composition Associated with Progressive Occlusion Duration. (1997)

The current study describes the histopathology of angiographic chronic total occlusions including residual lumen patency, intimal plaque composition, patterns of neovascular channel formation, intimal plaque calcification, and cellular inflammation, analyzed according to occlusion duration and intimal plaque type (fibrocalcific vs. lipid laden vs. mixed). Histologic findings are related to previously described clinical and angiographic predictors of successful chronic total occlusion revascularization.