gebhart/patrepeval huggingface dataset:
Disease Tolerance Acquired Through Repeated Plasmodium Infection Involves Epigenetic Reprogramming of Innate Immune Cells (2023)

Summary The regulation of inflammation is a critical aspect of disease tolerance and naturally acquired immunity to malaria. Here, we demonstrate using RNA sequencing and epigenetic landscape profiling by cytometry by Time-Of-Flight (EpiTOF), that the regulation of inflammatory pathways during asymptomatic parasitemia occurs downstream of pathogen sensing—at the epigenetic level. The abundance of certain epigenetic markers (methylation of H3K27 and dimethylation of arginine residues) and decreased prevalence of histone variant H3.3 correlated with suppressed cytokine responses among monocytes of Ugandan children. Such an epigenetic signature was observed across diverse immune cell populations and not only characterized active asymptomatic parasitemia but also predicted long-term future disease tolerance when observed in uninfected children. This broad methylated signature likely develops gradually and was associated with age and recent parasite exposure. Our data support a model whereby exposure to Plasmodium falciparum induces epigenetic changes that regulate excessive inflammation and contribute to naturally acquired immunity to malaria.
Adaptive QoS and resource management using a posteriori workload characterizations (2003)

Certain real-time applications must operate in highly dynamic environments (e.g., battle environments), thereby precluding accurate characterization of the applications' workloads by static models. Thus, static guarantees of real-time performance based on a priori characterizations are not possible. However, potential benefits of a posteriori approaches are significant, including the ability to function correctly in dynamic environments (through adaptability to unforeseen conditions), and higher actual utilization of computing resources. In this paper, we present an approach that is appropriate for systems which experience large variations in workload. A distributed collection of computing resources is managed by continuously computing and assessing QoS and resource utilization metrics that are determined a posteriori. The utility of our approach is shown by applying it to a large, experimental distributed Navy computing system.
First study of the CP-violating phase and decay-width difference in Bs0→ψ(2S)ϕ decays (2016)

A time-dependent angular analysis of B 0 s (2S) decays is performed using data recorded by the LHCb experiment. The data set corresponds to an integrated luminosity of 3.0 fb -1 collected during Run 1 of the LHC. The CP-violating phase and decay-width difference of the B 0 s system are measured to be s = 0.23 +0.29 -0.28 0.02 rad and s = 0.066 +0.041 -0.044 0.007 ps -1 , respectively, where the first uncertainty is statistical and the second systematic. This is the first time that s and s have been measured in a decay containing the (2S) resonance.
Functionalization of the carbon additive of a high-voltage Li-ion cathode (2018)

Modification of the carbon additive improves the stability of a LiMn<sub>1.5</sub>Ni<sub>0.5</sub>O<sub>4</sub> composite cathode.
Low Rate of Infection Control in Enterococcal Periprosthetic Joint Infections (2012)

Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
Natural History of Intraocular Pressure in the Early Manifest Glaucoma Trial (2010)

In patients with early glaucoma, IOP remained stable without treatment during a 6-year period, regardless of baseline IOP, except for patients with exfoliation glaucoma, where IOP increased by almost 1 mm Hg annually. No factors, aside from exfoliation glaucoma, were related to longitudinal changes in IOP. These new natural history data may be useful in guiding management decisions for glaucoma treatment, particularly in patients with early disease or with exfoliation glaucoma.
Synthesis of a new bifunctional chelating agent for radioimmunotherapy: Cyclohexyl fused tetraazacyclodo-decanetetraacetic acid (1996)

Preorganization of the coordinating groups within a chelating agent increases the stability of its metal-ligand complexes. For example, 1,2-diaminocyclo-hexanetetraacetic acid (CDTA) forms metal complexes with stability constants 1-3 orders of magnitude higher than the corresponding complexes of EDTA. Incorporation of a cyclohexyl group into a macrocyclic ligand produces a similar effect; stability constants of Cu complexes of tetrathiocyclotetradecanes are increased by 1.5 orders of magnitude by incorporating one cyclohexyl group into the macrocyclic ring and 3 orders of magnitude by incorporating two cyclohexyl moieties. In this study, we have synthesized cycohexyl DOTA (C-DOTA) in which the cyclohexyl group is fused to two carbons of the macrocyclic ring. Alkylation of disodium ethylene ditosylamide with trans-1,2-di(bromoacetamido)cyclohexane afforded the C{sub 8}N{sub 4} macrocycle. Reduction with lithium aluminum hydride not only reduced the amide moieties to amines but also removed the tosyl protecting groups affording the cyclohexylcyclen. Cyanomethylation followed by hydrolysis gave C-DOTA in an overall yield of 9.4%. C-DOTA is expected to offer improvements in the biodistribution of radiometal immunoconjugates for radioimmunotherapy, in particular with Sc-47, Y-90, and Sm-153 that have given encouraging results using the plain DOTA ligand.
Abstract WP285: tPA Variant tPA-A296-299 Prevents Impairment of Cerebral Autoregulation and Hippocampal Neuronal Necrosis After Stroke Through Inhibition of ET-1 Upregulation (2017)

Introduction: The sole FDA approved treatment for acute stroke is tissue type plasminogen activator (tPA). However, its brief therapeutic window and post-treatment complications markedly constrain its use. The limited efficacy of tPA may be explained in part by our finding that it potentiates impairment of cerebral autoregulation after stroke in pigs. Upregulation of JNK MAPK after thrombotic stroke contributes to tPA mediated impairment of autoregulation. However, the role of ET-1, and its relationship to JNK, in impairment of autoregulation is unknown. Impairment of autoregulation is linked to Glasgow Coma Scale after brain injury, but unknown if autoregulation correlates with hippocampal histopathology after stroke. Hypothesis: Wild type (wt) tPA can bind to either the lipoprotein-related receptor (LRP), which mediates vasodilation, or NMDA-Rs. We propose that wt tPA given after stroke primarily binds to NMDA-Rs, upregulates ET-1 in a JNK dependent manner, which impairs autoregulation, causing histopathology. tPA-A 296-299 , a variant that is fibrinolytic but cannot bind to NMDA-Rs, preferentially binds LRP, which blocks ET-1 and JNK upregulation and limits impairment of autoregulation and histopathology after stroke. Methods: Anesthetized pigs equipped with a closed cranial window were used. Stroke was induced by photothrombosis, CBF determined by radiolabeled microspheres, CSF ET-1 and JNK determined by ELISA and histopathology determined with H + E stain. Results: CBF was unchanged during hypotension (mean arterial pressure decreased by 45%) in sham animals. CBF was reduced in brain tissue surrounding the infarct and was reduced further during hypotension, indicating impairment of autoregulation. CA1 and CA3 neuronal cell necrosis and autoregulation were further impaired by wt tPA which was prevented by BQ 123 and tPA-A 296-299 . Cerebral ET-1 was increased by stroke, potentiated by wt tPA, but returned to sham baseline value by tPA-A 296-299 and the JNK antagonist SP600125. Conclusions: JNK contributes to ET-1 release after stroke. tPA-A 296-299 prevents impairment of cerebral autoregulation and histopathology after stroke through inhibition of ET-1 upregulation.
Control of Cutting Force for Creep-Feed Grinding Processes Using a Multi-Level Fuzzy Controller (2006)

In this paper, a multi-level fuzzy control (MLFC) technique is developed and implemented for a creep-feed grinding process. The grinding force is maintained at the maximum allowable level under varying depth of cut, so that the highest metal removal rate is achieved with a good workpiece surface quality. The control rules are generated heuristically without any analytical model of the grinding process. Based on the real-time force measurement, the control parameters are adapted automatically within a stable range. A National Instrument real-time control computer is implemented in an open architecture control system for the grinding machine. Experimental results show that the cycle time has been reduced by up to 25% over those without force control and by 10–20% compared with the conventional fuzzy logic controller, which indicates its effectiveness in improving the productivity of actual manufacturing processes. The effect of grinding wheel wear is also considered in the creep-feed grinding process, where the grinding force/power can be maintained around the specified value by the proposed MLFC controller as the wheel dulls gradually.
Balancing is the Key - Performing Finger Vein Template Protection using Fuzzy Commitment (2015)

We propose a novel vein extraction technique adapted to template protection and use it to apply a fuzzy

commitment scheme. We construct dedicated error correcting codes that enable us to maintain a good accuracy

after template protection. In a second application, we offer to overcome the alignment issues when comparing

two vein templates by performing this step outside of the protection scheme. Different implementations are

proposed to explore trade-offs between False Rejection Rate, False Acceptance Rate, comparison time and

security. All approaches are tested on the recent database of University of Twente from ICB 2013. Our

biometric performances are close to state of the art approaches whilst bringing security with the template

protection scheme.
Homogeneity and variation of donor doping in Verneuil-grown SrTiO3:Nb single crystals (2016)

The homogeneity of Verneuil-grown SrTiO3:Nb crystals was investigated. Due to the fast crystal growth process, inhomogeneities in the donor dopant distribution and variation in the dislocation density are expected to occur. In fact, for some crystals optical studies show variations in the density of Ti(3+) states on the microscale and a cluster-like surface conductivity was reported in tip-induced resistive switching studies. However, our investigations by TEM, EDX mapping, and 3D atom probe reveal that the Nb donors are distributed in a statistically random manner, indicating that there is clearly no inhomogeneity on the macro-, micro-, and nanoscale in high quality Verneuil-grown crystals. In consequence, the electronic transport in the bulk of donor-doped crystals is homogeneous and it is not significantly channelled by extended defects such as dislocations which justifies using this material, for example, as electronically conducting substrate for epitaxial oxide film growth.
Mixed-Integer Linear Regression Kalman Filters for GNSS Positioning (2021)

In this paper, recursive filters are formulated for the mixed-integer GNSS receiver estimation problem, where the integer variables come from the ambiguities in the carrier-phase measurements. Insights from the linear setting illustrate pitfalls in designing optimal recursive filters, motivating a relaxation of the original optimization problem and a departure from conventional methods. A set of filters are developed for sequential nonlinear mixed-integer estimation based on statistical linearization, entertaining two estimate densities and taking the time-evolution of the ambiguities into account by adapting the process noise covariance based on a statistical model. Numerical examples illustrate the efficacy of the proposed algorithms.
DMMP vapor detection with 50NM thick AlN films based microcantilevers (2011)

In this paper, we demonstrate the high sensing performances of a DMMP vapor sensor system based on 50 nm thick AlN film microcantilevers. These devices are particularly interesting for low power integrated gas sensors systems. One key factor for their gas sensing performances optimization relies on the reduction of the AlN layer thickness. Thanks to a digital PLL setup we demonstrate high frequency stability with an Allan deviation of 5.10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-8</sup> . Finally, using DKAP polymer for surface functionalization of the cantilever, we measure DMMP vapor concentration down to 25 ppb and predict from frequency noise an ultimate resolution of 10 ppb at the level of the state of the art of DMMP sensing.
RF Injection Network Development for Testing of Active Implantable Medical Devices Exposed to RF Fields in 1.5 T MRI Systems (2019)

This paper presents the design, construction, and testing of an RF injection network for MR-conditional medical testing of devices for use within 1.5 T MRI scanners (i.e., frequency of 63.4 MHz). The system was developed to meet the requirements of ISO/TS 10974:2018(E). A directional lumped element coupler, power splitter, an attenuator/isolator, low-pass filter, and high-pass filter were designed and implemented as part of the network. The RF injection network was developed in both a compact version implemented in a single PCB and discrete PCB version for use in different situations. The performance of each designed component was simulated and compared to measurement results. As an application example, a neuromodulation system was tested using the developed RF injection network for conductive emission testing.
Error vector magnitude to SNR conversion for nondata-aided receivers (2009)

Error vector magnitude (EVM) is one of the widely accepted figure of merits used to evaluate the quality of communication systems. In the literature, EVM has been related to signal-to-noise ratio (SNR) for data-aided receivers, where preamble sequences or pilots are used to measure the EVM, or under the assumption of high SNR values. In this paper, this relation is examined for nondata-aided receivers and is shown to perform poorly, especially for low SNR values or high modulation orders. The EVM for nondata-aided receivers is then evaluated and its value is related to the SNR for quadrature amplitude modulation (QAM) and pulse amplitude modulation (PAM) signals over additive white Gaussian noise (AWGN) channels and Rayleigh fading channels, and for systems with IQ imbalances. The results show that derived equations can be used to reliably estimate SNR values using EVM measurements that are made based on detected data symbols. Thus, presented work can be quite useful for measurement devices such as vector signal analyzers (VSA), where EVM measurements are readily available.
Jitter camera: a super-resolution video camera (2006)

Video cameras must produce images at a reasonable frame-rate and with a reasonable depth of field. These requirements impose fundamental physical limits on the spatial resolution of the image detector. As a result, current cameras produce videos with a very low resolution. The resolution of videos can be computationally enhanced by moving the camera and applying super-resolution reconstruction algorithms. However, a moving camera introduces motion blur, which limits super-resolution quality. We analyze this effect and derive a theoretical result showing that motion blur has a substantial degrading effect on the performance of super resolution. The conclusion is, that in order to achieve the highest resolution, motion blur should be avoided. Motion blur can be minimized by sampling the space-time volume of the video in a specific manner. We have developed a novel camera, called the "jitter camera," that achieves this sampling. By applying an adaptive super-resolution algorithm to the video produced by the jitter camera, we show that resolution can be notably enhanced for stationary or slowly moving objects, while it is improved slightly or left unchanged for objects with fast and complex motions. The end result is a video that has a significantly higher resolution than the captured one.
New techniques for compiling data-parallel languages (1996)

Data-parallel programming languages provide a portable, high level abstraction to support rapid parallel program development. Data-parallel languages are widely applicable, and considerable research has been devoted to compiling them for efficient execution. Much of this work has focused on implementing a shared address space on a distributed-memory machine, particularly for programs with regular communication patterns. Compiler support for non-regular applications has been limited to iterative irregular applications, with dynamic repetitive communication patterns.
This thesis describes three new compiler, language and run-time system techniques targeting data-parallel programs with adaptive and dynamic communication patterns. These techniques have been implemented in a compiler for the language C$\sp{**}$, and include:
Implementing conflict-free data access. C$\sp{**}$'s semantics avoid data access conflicts between parallel functions. We explore and compare two complementary implementations of conflict-free access. For parallel functions with regular data access patterns, the compiler inserts code in the program to maintain copies. When compiler data access analysis is imprecise, the compiler relies on a Loosely-Coherent Memory system to create transparent fine-grain copies.
User-defined reductions. Most data-parallel languages restrict reductions, which combine values from parallel operations, to a predefined set of reduction operators. User-defined reductions extend reductions in two ways, by allowing new combining operations, and by applying reductions to user-defined data types. This thesis motivates the need for user-defined reductions, and describes the design and efficient implementation of reductions in C$\sp{**}$ with only message-passing support.
Compiler-directed shared-memory communication. This thesis describes how a compiler and a predictive cache-coherence protocol can implement shared-memory communication efficiently for iterative adaptive applications. The compiler uses data-flow analysis to identify points in a program where potential repetitive communication patterns exist. An incremental predictive protocol builds a communication schedule for one iteration and utilizes a schedule to pre-send data in subsequent iterations. The protocol reduces the number of remote data requests, and the total remote access latency.
Amsterdam Oxford Joint Rescue Forces: Team description paper: Virtual Robot competition: Rescue Simulation League: RoboCup 2010 and Iran Open (2010)

With the progress made in active exploration, the robots of the Joint Rescue Forces are capable of making deliberative decisions about the distribution of exploration locations over the team. Experiments have been done which include information exchange between team-members at rendez-vous points. Last year progress has been made with robots with advanced mobility, such as the Kenaf and the AirRobot. Currently our navigation algorithms are extended to be able to autonomously explore with the AirRobots. Robots equipped with both camera and laser-range scanners can learn a visual classifier of free space, which could be used by robots without laser-range scanners to navigate through the environment. Part of our algorithms have been validated on the Nomad Super Scout II robot available in our laboratory.
Complications of Total Hip Arthroplasty: Standardized List, Definitions, and Stratification Developed by The Hip Society (2015)

Level V, therapeutic study.
Stretch-induced Wettability Changes of the Superhydrophobic Microstructured Vulcanized Rubber Surface (2018)

There have been a lot of artificial superhydrophobic surfaces, however, those are difficult to use in daily purposes because of their brittle, stiff and breakable properties. We have been reported fabrication of superhydrophobic microstructured vulcanized rubber surfaces by using silicon microstructures as mold during their vulcanization process. Furthermore, the arrangement of microstructures could be repeatedly transformed from a hexagonal to linear patterns by elongations and superhydrophobicity was kept during elongation process. In this report, we prepared other type of superhydrophobic microstructured vulcanized rubber surfaces, which can be changed surface wettability by stretching. The superhydrophobic microstructured vulcanized rubber surfaces were prepared by using a silicon microstructures as mold. After observation of surface structures and wettability by laser microscopy and water contact angle analyzer, we took high-speed photography of water droplets felled to the rubber surfaces with different elongation rates, and theoretically discussed the differences of water behaviors.
IL-2 and Beyond in Cancer Immunotherapy (2018)

The development of the T- and natural killer (NK) cell growth factor IL-2 has been a sentinel force ushering in the era of immunotherapy in cancer. With the advent of clinical grade recombinant IL-2 in the mid-1980s, oncologists could for the first time directly manipulate lymphocyte populations with systemic therapy. By itself, recombinant IL-2 can induce clinical responses in up to 15% of patients with metastatic cancer or renal cell carcinoma. When administered with adoptively transferred tumor-reactive lymphocytes, IL-2 promotes T cell engraftment and response rates of up to 50% in metastatic melanoma patients. Importantly, these IL-2-driven responses can yield complete and durable responses in a subset of patients. However, the use of IL-2 is limited by toxicity and concern of the expansion of T regulatory cells. To overcome these limitations and improve response rates, other T cell growth factors, including IL-15 and modified forms of IL-2, are in clinical development. Administering T cell growth factors in combination with other agents, such as immune checkpoint pathway inhibitors, may also improve efficacy. In this study, we review the development of T- and NK cell growth factors and highlight current combinatorial approaches based on these reagents.
Rehabilitation engineering research center (RERC) on access to computers and information systems* (1995)

The Trace Center at the University of Wisconsin-Madison is designated as a Rehabilitation Engineering Research Center (RERC) on the topic of Adaptive Computers and Information Systems. The purpose of this Center is to ‘assure that individuals with disabilities will have adequate accessible technolo gy and technology interface to assist them to participate fully in the communication and rapid exchange of information that will be integral to the economy and lifestyle of the future.’ This priority stems from a concern that an increasingly technical society has the potential for becoming more and more inaccessible to individuals with impairments. Information systems, including but not limited to computers, are now becoming essential components in the workplace, education, home life, and increasingly community life as well. The RERC addresses three types of technologies: (1) Microcomputers and other programmable, flexible input/output devices; (2) Next-generation information systems and the information super-highway, and (3) Existing and emerging communication and of the Center include: working with makers of mass-market equipment and software to improve their designs; basic and applied research on human factors and disability issues as they relate to information systems; development of guidelines and standards for computer and information system accessibility; and information and outreach efforts to involve consumers in the development of guidelines and accessible designs.
Decreased Alloreactivity Using Donor Cells from Mice Expressing a CD200 Transgene Under Control of a Tetracycline-Inducible Promoter (2005)

Our data confirmed that overexpression of CD200 in transgenic mice, or in skin grafts from these mice, decreases alloimmunity. This has potential clinical utility in transplantation and other diseases.