gebhart/patrepeval huggingface dataset:
An architecture for privacy-preserving sharing of CTI with 3rd party analysis services (2017)

Increasing numbers of Small and Medium Enterprises (SME) are outsourcing or hosting their services on different Cloud Service Providers (CSP). They are also using different security services from these CSPs such as firewalls, intrusion detection/prevention systems and anti-malware. Although for the SMEs the main purpose of using these security services is to protect their cyber assets, either physical or virtual, from security threats and compromises, a very useful and valuable by-product of these security services is the wealth of Cyber Threat Information (CTI) that is collected over time. However, a common problem faced by SMEs is that they lack the resources and expertise for monitoring, analysing and reacting to any security notifications, alerts or events generated by the security services they have subscribed to. An obvious solution to this problem is that the SMEs outsource this problem to a cloud based service as well, by sharing their CTI with this service and allowing it to analyse the information and generate actionable reports or patches. The more CTI obtained from different SMEs, the better the analysis result. In this paper, we try to address some of the privacy and confidentiality issues that arise as a result of different SMEs sharing their CTI with such a third party analysis service for the aggregate analysis scenario we just described. We present the design and architecture of our solution that aims to allow SMEs to perform policy-based sharing of CTI, while also offering them flexible privacy and confidentiality controls.
Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients (2015)

The immunosurveillance mechanisms governing high-risk neuroblastoma (HR-NB), a major pediatric malignancy, have been elusive. We identify a potential role for natural killer (NK) cells, in particular the interaction between the NK receptor NKp30 and its ligand, B7-H6, in the metastatic progression and survival of HR-NB after myeloablative multimodal chemotherapy and stem cell transplantation. NB cells expressing the NKp30 ligand B7-H6 stimulated NK cells in an NKp30-dependent manner. Serum concentration of soluble B7-H6 correlated with the down-regulation of NKp30, bone marrow metastases, and chemoresistance, and soluble B7-H6 contained in the serum of HR-NB patients inhibited NK cell functions in vitro. The expression of distinct NKp30 isoforms affecting the polarization of NK cell functions correlated with 10-year event-free survival in three independent cohorts of HR-NB in remission from metastases after induction chemotherapy (n = 196, P < 0.001), adding prognostic value to known risk factors such as N-Myc amplification and age >18 months. We conclude that the interaction between NKp30 and B7-H6 may contribute to the fate of NB patients and that both the expression of NKp30 isoforms on circulating NK cells and the concentration of soluble B7-H6 in the serum may be clinically useful as biomarkers for risk stratification.
<title>Transducer-based measurements of Terfenol-D material properties</title> (1996)

Quantification of Terfenol-D material properties is not readily achieved through standard stress-strain test procedures due to the sensitivity of material properties to changes in magnetic and mechanical loads. A Terfenol-D transducer can be used to measure material properties under varied operating conditions. The development of the measurement and calculation procedures used to obtain material properties is based on the model of low signal, linear magnetostriction, linear transduction equations for a transducer, and a one degree of freedom mechanical model of the transducer. Vector impedance and admittance analysis is used to determine the transducer resonant, anti-resonant, and half power point frequencies. Using these frequencies, acceleration from an accelerometer mounted on the transducer, readily measurable transducer and Terfenol-D rod parameters (mass, length, etc.), and the calculation procedures described, pertinent material properties such as the Young's moduli, permeabilities, magnetomechanical coupling factor, and the linear coupling coefficient (d<SUB>33</SUB>) can be determined. The subtleties of applying this theory to real world non-linear Terfenol-D operated in a transducer are addressed, including proper design and operation of a transducer to achieve circular Nyquist mobility loops. Experimental results from this method are compared with other research and the material property trends are found to be consistent.
Data from Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism Arrays (2023)

&lt;div&gt;Abstract&lt;p&gt;Recent advances in oligonucleotide arrays and whole-genome complexity reduction data analysis now permit the evaluation of tens of thousands of single-nucleotide polymorphisms simultaneously for a genome-wide analysis of allelic status. Using these arrays, we created high-resolution allelotype maps of 26 pancreatic cancer cell lines. The areas of heterozygosity implicitly served to reveal regions of allelic loss. The array-derived maps were verified by a panel of 317 microsatellite markers used in a subset of seven samples, showing a 97.1% concordance between heterozygous calls. Three matched tumor/normal pairs were used to estimate the false-negative and potential false-positive rates for identifying loss of heterozygosity: 3.6 regions (average minimal region of loss, 720,228 bp) and 2.3 regions (average heterozygous gap distance, 4,434,994 bp) per genome, respectively. Genomic fractional allelic loss calculations showed that cumulative levels of allelic loss ranged widely from 17.1% to 79.9% of the haploid genome length. Regional increases in “NoCall” frequencies combined with copy number loss estimates were used to identify 41 homozygous deletions (19 first reports), implicating an additional 13 regions disrupted in pancreatic cancer. Unexpectedly, 23 of these occurred in just two lines (BxPc3 and MiaPaCa2), suggesting the existence of at least two subclasses of chromosomal instability (CIN) patterns, distinguished here by allelic loss and copy number changes (original CIN) and those also highly enriched in the genomic “holes” of homozygous deletions (holey CIN). This study provides previously unavailable high-resolution allelotype and deletion breakpoint maps in widely shared pancreatic cancer cell lines and effectively eliminates the need for matched normal tissue to define informative loci. (Cancer Res 2006; 66(16): 7920-9)&lt;/p&gt;&lt;/div&gt;
Implementation of Three Level Inverter with Single Z- Source Network in MATLAB (2014)

Abstract- The Z-Source concept has many advantages and can be applied for any type of power conversion. Both boosting and modulation index can be controlled in inverter operation itself, by inserting proper shoot through states. This paper presents procedure for implementing, space vector modulated REC Z-source inverter in MATLAB SIMULINK by inserting shoot through states. It also explains a clear procedure of selection of shoot through states at required time and presents an overall tabular column of the sequence of switching states for three level space vector modulation. The proposed techniques are demonstrated in MATLAB and have achieved good performance results. Index Terms- MATLAB SIMULINK, REC Z-Source inverter, Space vector modulation (SVM)
POST-TRANSPLANT DE NOVO AUTOIMMUNITY CONTRIBUTES TO CARDIAC ALLOGRAFT REJECTION AND IT IS MEDIATED VIA INDIRECT PRESENTATION OF DONOR MHC PEPTIDES AND ORGAN-SPECIFIC AUTOANTIGENS. (2000)

Fedoseyeva, Eugenia V.1; Kishimoto, Koji2; Rolls, Hillary1; Sayegh, Mohamed H.2; Benichou, Gilles1 Author Information
Geophysical Imaging of Stimulated Microbial Biomineralization (2005)

Understanding how microorganisms influence the physical and chemical properties of the subsurface is hindered by our inability to observe microbial dynamics in real time and with high spatial resolution. Here, we investigate the use of noninvasive geophysical methods to monitor biomineralization at the laboratory scale during stimulated sulfate reduction under dynamic flow conditions. Alterations in sediment characteristics resulting from microbe-mediated sulfide mineral precipitation were concomitant with changes in complex resistivity and acoustic wave propagation signatures. The sequestration of zinc and iron in insoluble sulfides led to alterations in the ability of the pore fluid to conduct electrical charge and of the saturated sediments to dissipate acoustic energy. These changes resulted directly from the nucleation, growth, and development of nanoparticulate precipitates along grain surfaces and within the pore space. Scanning and transmission electron microscopy (SEM and TEM) confirmed the sulfides to be associated with cell surfaces, with precipitates ranging from aggregates of individual 3-5 nm nanocrystals to larger assemblages of up to 10-20 microm in diameter. Anomalies in the geophysical data reflected the distribution of mineral precipitates and biomass over space and time, with temporal variations in the signals corresponding to changes in the aggregation state of the nanocrystalline sulfides. These results suggest the potential for using geophysical techniques to image certain subsurface biogeochemical processes, such as those accompanying the bioremediation of metal-contaminated aquifers.
Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as a Vaccine Adjuvant (2017)

The quest for new potent and safe adjuvants with which to skew and boost the immune response of vaccines against intracellular pathogens and cancer has led to the discovery of a series of small molecules that can activate Toll-like receptors (TLRs). Whereas many small molecule TLR agonists cope with a problematic safety profile, amphotericin B (AmpB), a Food and Drug Administration approved antifungal drug, has recently been discovered to possess TLR-triggering activity. However, its poor aqueous solubility and cytotoxicity at elevated concentrations currently hampers its development as a vaccine adjuvant. We present a new class of transiently thermoresponsive polymers that, in their native state, have a phase-transition temperature below room temperature but gradually transform into fully soluble polymers through acetal hydrolysis at endosomal pH values. RAFT polymerization afforded well-defined block copolymers that self-assemble into micellar nanoparticles and efficiently encapsulate AmpB. Importantly, nanoencapsulation strongly reduced the cytotoxic effect of AmpB but maintained its TLR-triggering capacity. Studies in mice showed that AmpB-loaded nanoparticles can adjuvant an RSV vaccine candidate with almost equal potency as a highly immunogenic oil-in-water benchmark adjuvant.
Novel therapeutic targets for preserving a healthy endothelium: strategies for reducing the risk of vascular and cardiovascular disease. (2011)

The endothelium lies in a strategic anatomical position between the circulating blood and the vascular smooth-muscle cells. It is a source of vasodilators such as nitric oxide, prostacyclin, and hyperpolarizing factor as well as heparin-like substances and other molecules with antiproliferative properties. These effects of endothelial cells may explain why platelets and monocytes usually do not adhere at the blood vessel wall. However, under pathological conditions, endothelial dysfunction occurs and significantly contributes to the increase of platelet- -vessel wall interaction, vasoconstriction, pro-inflammation, and proliferation. Under these conditions, endothelium-dependent vasodilation is reduced, and endothelium-dependent constrictor responses are augmented. Upon vessel wall injury, the platelets rapidly adhere to the exposed sub-endothelial matrix, which is mediated by several cellular receptors present on platelets or endothelial cells and various adhesive proteins. Subsequent platelet activation results in the recruitment of additional platelets and the generation of platelet aggregates, so forming a stable platelet plug. Therapeutic strategies aimed at improving or preserving endothelial function therefore may be promising in terms of preventing and treating coronary artery disease. Diagnostic modalities for assessing endothelial function should allow for the early detection of vascular endothelial dysfunction before the manifestation of serious adverse vascular disorders.
Guidelines for periodontal prostheses serve esthetic and functional demands: a case report. (2002)

Periodontal-prosthesis guidelines have long been defined to specifically address dental reconstructions after moderate to advanced periodontal disease has occurred. More recently, specific dental techniques and materials have shown promise in addressing patients' increasing esthetic demands. However, treatment planning to achieve pleasing results for patients with advanced periodontitis requires a complex, multispecialty approach that is rarely discussed. A case report and literature review illustrate that the original periodontal-prosthesis guidelines not only remain useful today for obtaining esthetic results but also conform to recent understanding of maxillomandibular physiology.
From Analysis to Communication (2018)

This chapter discusses the current practices as expressed by data storytellers, gives an overview of the tools that are in use, and details opportunities for research and design. Coinciding with advancements in Web-based visualization technology and the proliferation of mobile devices, there has been a rapid growth of novel visual data stories on the Web as well as in other formats such as infographics and data videos. The chapter describes a methodology for eliciting and analyzing feedback from these professionals, and discusses major insights gained from our qualitative analysis. With the diverse activities comprising the process of creating a visual data story, there are also various roles and skill sets distributed among the coauthors such as artists, designers, and developers. Companies and institutes often have de facto standards for preferred tools, and for instance, a local data base management system (DBMS) or content management system (CMS) can impose considerable constraints on the production of a data story.
Supplementary Figures 1-6 from Hypoxia-Inducible miR-210 Regulates the Susceptibility of Tumor Cells to Lysis by Cytotoxic T Cells (2023)

&lt;p&gt;PDF file - 779K, This file contains data showing miRNAs upregulated by hypoxia in IGR-Heu and NA-8 cell lines and miR-210 upregulated under hypoxia in several NSCLC and melanoma cell lines. It also contains figure showing the role of hypoxia induced miR-210 in CTL clone-mediated lysis towards NA-8 cells and the effect of miR-210 on hypoxia-induced factors in IGR-Heu cells. Finally it shows the list of 44 validated miR-210 targets from miRanda and the Enrichment of mir-210 in Argonaute complex after IGR-Heu cells were exposed to hypoxia&lt;/p&gt;
Stimulation of glucocorticoid‐induced tumor necrosis factor receptor family‐related protein ligand (GITRL) induces inflammatory activation of microglia in culture (2010)

Glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) is a member of the tumor necrosis factor superfamily (TNFSF) and is known to act as a costimulator in the immune system by binding to GITR. GITRL is expressed in endothelial cells, dendritic cells, macrophages, and B cells, but it is not known whether GITRL is expressed in brain microglia cells. Here, we investigated the expression of GITR and GITRL and their potential role in microglia cells. Using BV-2 mouse microglia cells and mouse primary microglia cultures, we have demonstrated that 1) both GITR and GITRL are expressed in microglia cells; 2) stimulation of GITRL induces inflammatory activation of microglia on the basis of production of nitric oxide (NO) and expression of inducible nitric oxide synthase, cyclooxygenase-2, CD40, and matrix metalloproteinase-9; 3) GITRL-mediated microglial NO production partially depends on p38 MAPK, JNK, and nuclear factor-kappaB pathways; and 4) GITRL stimulation also induces microglia cell death. These results indicate that GITR and GITRL are functionally expressed on brain microglia and that the stimulation of GITRL can induce inflammatory activation of microglia. The GITR/GITRL system may play an important role in neuroinflammation.
A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays (2015)

Cardiomyocytes from human stem cells have applications in regenerative medicine and can provide models for heart disease and toxicity screening. Soluble components of the culture system such as growth factors within serum and insoluble components such as the substrate on which cells adhere to are important variables controlling the biological activity of cells. Using a combinatorial materials approach we develop a synthetic, chemically defined cellular niche for the support of functional cardiomyocytes derived from human embryonic stem cells (hESC-CMs) in a serum-free fully defined culture system. Almost 700 polymers were synthesized and evaluated for their utility as growth substrates. From this group, 20 polymers were identified that supported cardiomyocyte adhesion and spreading. The most promising 3 polymers were scaled up for extended culture of hESC-CMs for 15 days and were characterized using patch clamp electrophysiology and myofibril analysis to find that functional and structural phenotype was maintained on these synthetic substrates without the need for coating with extracellular matrix protein. In addition, we found that hESC-CMs cultured on a co-polymer of isobornyl methacrylate and tert-butylamino-ethyl methacrylate exhibited significantly longer sarcomeres relative to gelatin control. The potential utility of increased structural integrity was demonstrated in an in vitro toxicity assay that found an increase in detection sensitivity of myofibril disruption by the anti-cancer drug doxorubicin at a concentration of 0.05 μM in cardiomyocytes cultured on the co-polymer compared to 0.5 μM on gelatin. The chemical moieties identified in this large-scale screen provide chemically defined conditions for the culture and manipulation of hESC-CMs, as well as a framework for the rational design of superior biomaterials.
Xylanase-Induced Liberation of Negatively Charged Species and Their Effect on Colloidal Interactions and the Retention of Bleached Kraft Pulp Fibers (2015)

The ability and specificity of various monocomponent endo-1-4-β-xylanases to release negatively charged species from never-dried, bleached, birch kraft pulp was studied. The effects of dissolution of these xylan-based components on pulp filtrate properties and the subsequent chemical retention were determined. The results revealed that the amount of charged species released depended on the xylanase and that the ratio of charged species released to dissolved xylan is not linear. Chemical retention tests showed that high levels of dissolved xylan interfere with the fixation of colloidal species, which was confirmed by removing the dissolved hemicelluloses. The roles of residual hemicellulose and the properties of modified fibers on chemical retention and the level of internal sizing are discussed.
ChemInform Abstract: Synthesis and Properties of Ionic Liquids Derived from the “Chiral Pool”. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
598. Effective Humoral and Cellular Smallpox-Immune Responses Using a Combination of Plasmids Delivered by Intramuscular Injection Followed by Constant-Current Electroporation in Rabbits (2006)

Previous studies have examined smallpox antigen-expressing plasmids in mice and non-human primates with limited efficacy. Recent studies showed that the electroporation technique can be used to dramatically increase plasmid uptake into the target tissues (e.g., skeletal muscle) when compared to simple injection. Consequently, the expression levels for the encoded transgene are orders of magnitude higher, likely improving potency. In a pilot experiment, uptake and distribution of plasmids with and without electroporation have been analyzed in the rabbit. Electroporated muscle showed a better distribution and uptake. We evaluated immune responses to smallpox antigens, after direct intramuscular plasmid injection followed by constant-current electroporation in groups of rabbits (n=3/group). The plasmids were administered either individually or in combination and their relative responses analyzed. Group 1 rabbits were immunized with a combination of eight plasmids expressing varying smallpox antigens (A13L, A14L, A27L, A33L, B5R, D8L, H3L, L1R). Group 2 rabbits were immunized with a combination of four different antigens (A27L, B5R, D8L, L1R). The final group received an immunization with an individual plasmid expressing a single antigen (B5R). All plasmids were administered via a single IM injection of 800 μg (100 μg each antigen and/or empty vector up to 800 μg per injection) into semimembranosus muscle followed by electroporation using the ADViSYS constant-current EKD system, at 0.6 Amps, 3 pulses, 52 ms/pulse, 1 sec between pulses. Rabbits were immunized twice, at Study d 0 and at Study d 64. Sera were collected from rabbits at different time points, including on Day 85 and used to determine antibody responses by protein ELISA. Antibody responses were improved by electroporation in both immunized groups irrespective of the number of antigens delivered. A specific ELISpot assay for TNF is being developed to determine T-cell response rates in rabbits following DNA immunization. Rabbit PBMCs collected 2 weeks after first immunization were stimulated for 24h with 15mer peptides that span the entire length of the A27L gene. Immunization followed by electroporation induced improved antigen specific T-cell responses against A27L. Thus, the combination immunization strategy using smallpox antigens and constant-current electroporation appears important for driving better humoral and cellular-based responses in a relevant animal model.