gebhart/patrepeval huggingface dataset:
The Impact of Differential Mode Delay on Mode-Division Multiplexed Coherent Optical OFDM Transmission (2012)

We analyze two-mode transmission for 402-Gb/s 3MDM-PM-QPSK-OFDM modulation and different DMD values. We show that only with low-DMD fiber it is possible to effectively equalize mode coupling and bridge long-haul transmission distances.
TAp63γ regulates hOgg1 (2007)

1076 Recently, it has been shown that p53 plays a role in BER via regulation of hOGG1. Therefore, we hypothesized that p63 might also regulate hOGG1. Ectopic expression of p63 increased OGG1 expression, while it’s knockdown by RNAi resulted in reduced OGG1 expression at both RNA and protein level. Increase in OGG1 expression by p63 was associated with decreased sensitivity to oxidative damage, while decrease in OGG1 expression by RNAi increased the sensitivity to oxidative damage. The OGG1 promoter region between -945 and -726 was found to contain p63 regulatory element. We also found that p63 bound directly to the OGG1 promoter. Our findings indicate that p63 may directly or indirectly regulate OGG1.
High molecular weight hydrophilic functional copolymers by free‐radical copolymerization of acrylamide and ofN‐acryloylmorpholine withN‐acryloxysuccinimide: Application to the synthesis of a graft copolymer (2003)

Abstract Free‐radical solution copolymerization of acrylamide (AAm) and of a disubstituted acrylamide derivative, N ‐acryloylmorpholine (NAM), with N‐acryloxysuccinimide (NAS) was investigated with the aim to obtain a copolymer of at least 100,000 g mol −1 . Different polymerization conditions likely to increase the molecular weight were studied such as monomer and initiator concentrations, temperature, and nature of the solvent. The molecular weights were determined by SEC using a light‐scattering detector. The grafting of end‐functionalized polysaccharide chains onto such high molecular weight poly(NAM‐ co ‐NAS) was performed and a graft copolymer bearing a high number of saccharidic branches was obtained. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 88: 1808–1816, 2003
3D Particle‐Free Printing of Biocompatible Conductive Hydrogel Platforms for Neuron Growth and Electrophysiological Recording (2021)

Electrically conductive 3D periodic microscaffolds are fabricated using a particle-free direct ink writing approach for use as neuronal growth and electrophysiological recording platforms. A poly (2-hydroxyethyl methacrylate) (pHEMA)/pyrrole ink, followed by chemical <i>in situ</i> polymerization of pyrrole, enables hydrogel printing through nozzles as small as 1 μm. These conductive hydrogels can pattern complex 2D and 3D structures and have good biocompatibility with test cell cultures (~94.5% viability after 7 days). Hydrogel arrays promote extensive neurite outgrowth of cultured <i>Aplysia californica</i> pedal ganglion neurons. This platform allows extracellular electrophysiological recording of steady-state and stimulated electrical neuronal activities. In summation, this 3D conductive ink printing process enables preparation of biocompatible and micron-sized structures to create customized <i>in vitro</i> electrophysiological recording platforms.
Network Connectivity and Long-Range Continuity of Lamellar Morphologies in Block Copolymer Thin Films (2012)

The connectivity, and thus long-range continuity of the domains, in a lamellar polystyrene-block-poly(methyl methacrylate) copolymer in thin films depends on the volume fraction of each block and can be shifted by homopolymer addition to substrate-spanning continuity of either the polystyrene (PS) or poly(methyl methacrylate) (PMMA) domains. Essential features of the lamellar morphology were captured by a simple network analysis that quantified the number of branch points and end points in the lamellar domains. The transition in network continuity from the PS to PMMA domain as a function of copolymer volumetric composition (from fPMMA = 0.45 to 0.55) was correlated with a 5-fold increase in the PMMA branch point density and a concomitant 3-fold reduction in the PMMA end point density. These results indicate that the copolymer's composition drastically impacts the self-assembled lamellar morphology in thin films and is an important design consideration when using such materials for lithographic applications, including for directed assembly to generate long-range, defect-free order.
α‐Carbonyl Substituent Effect on the Lifetimes of Triplet 1,4‐Biradicals from Norrish‐Type‐II Reactions (2006)

Triplet 1,4-biradicals were generated by Norrish-Type-II hydrogen transfer from alpha-heteroatom-substituted beta-branched butyrophenones 1-6 and detected by laser flash absorption measurements. For three oxy-substituted compounds 2-4 (R(alpha)=OH, OCOMe, OCOOEt) comparable lifetimes were determined in acetonitrile (roughly 1.5 micros). In benzene, divergent trends were observed: for the hydroxy compound 2 a lower lifetime of 790 ns was determined, whereas for 3 and 4 the lifetimes increased to 4.9 micros. Photolyses of the alpha-amino-substituted compounds 1 and 6 resulted in transient species with significant lower lifetimes (for 1 160 ns in benzene and 450 ns in acetonitrile; for 6 <100 ns in both solvents). The mesyloxy substrate 5 undergoes rapid C-O bond cleavage upon photolysis and no transient triplet species were detected. Computational (UB3 LYP/6-31G* and natural don orbital (NBO) analyses) results supported the assumption of a negative hyperconjugative interaction strongly stabilizing alpha-oxy-substituted over alpha-amino-substituted radicals.
A Study on the Market Size Distribution of Artificial Information Industry (2016)

본 연구는 지능정보산업을 대상으로 시장규모분포와 세부 부분별 엔트로피를 추정하였다. 설문조사를 통해 총 147개 지능정보 산업 종사 기업의 매출 데이터를 확보하였으며, 인프라, 플랫폼, 서비스 부문별 혼합감마분포의 모수를 추정하였다. 표본 집단의 관측치가 정규분포를 따르지 않고 한쪽으로 편향된 경우 감마분포의 적용은 추정치의 왜곡과 실패를 방지하는 적합한 방법이다. 분설 결과 지능정보산업의 서비스 비중은 85.71%로 가장 높았으며, 플랫폼 비중은 4.08%으로 추정되어 단순 산술평균치와 차이를 보였다. 엔트로피 계산 결과, 서비스 부문은 시장 규모가 가장 크고 불확실성이 가장 낮아 민간의 활발한 참여가 예상된다. 반면 플랫폼 부문의 경우 시장 규모 비중이 낮고 불확실성이 가장 높아 균형 잡힌 지능정보산업 육성을 위해서는 산업육성정책이 동반되어야함을 알 수 있다. 본 연구 결과는 산업 정책의 기초자료로 활용될 수 있을 것이다.
POST‐MORTEM STABILITY OF PROGESTERONE IN RAT BRAIN (1986)

Progesterone concentrations in the brains of female rats kept at +20 degrees C or +4 degrees C for 0 to 48 hours after death were investigated. After two hours at +20 degrees C the progesterone concentration in seven studied brain areas were equal to that in control brains (dissected immediately after death). After four hours at +20 degrees C, levels decreased significantly in three brain regions. Intact rats that were placed in a refrigerator (+4 degrees C) after four hours at room temperature (+20 degrees C) showed no further changes in brain progesterone concentration. In the control group, the cerebral cortex, the hypothalamus and the hippocampus contained progesterone levels significantly higher than in all other areas (p less than 0.05). After four hours at room temperature only the hypothalamus showed higher levels (p less than 0.05). In conclusion, time after death and storage temperature affect the post-mortem levels of progesterone. Because of their differences in body masses, the conditions in the rat brain are not comparable to those in the human brain. However, it might be possible to study the regional distribution of progesterone in the human brain if control cases matched with regard to post-mortal time and brain temperature are used.
Resilient decentralized optimization in multi-agent networks with data injection attack (2021)

This paper studies resilient decentralized optimization over multi-agent networks. In particular, we consider the scenario where all networked agents are supposed to parallelly minimize the same objective function with a unique minimizer, but some agents are under data injection attack that perturb their minimizers away from the true minimizer. The goal is to ensure that all agents resiliently recover the true minimizer. We propose a consensus+innovations type of algorithm with signed innovations, to track the coordinate-wise median of all local (possibly perturbed) minimizers. We assume that all local iterates are sublinearly convergent, and the inter-agent undirected communication network is connected on average. We show that, as long as at least one agent is unattacked, and the median of all local minimizers is the true minimizer, the proposed decentralized algorithm asymptotically converges to the true minimizer almost surely at an sublinear rate. Numerical experiments are provided to demonstrate the effectiveness of the algorithm.
Burkholderia pseudomalleikills the nematodeCaenorhabditis elegansusing an endotoxin-mediated paralysis (2001)

We investigated a non-mammalian host model system for fitness in genetic screening for virulence-attenuating mutations in the potential biowarfare agents Burkholderia pseudomallei and Burkholderia mallei. We determined that B. pseudomallei is able to cause 'disease-like' symptoms and kill the nematode Caenorhabditis elegans. Analysis of killing in the surrogate disease model with B. pseudomallei mutants indicated that killing did not require lipopolysaccharide (LPS) O-antigen, aminoglycoside/macrolide efflux pumping, type II pathway-secreted exoenzymes or motility. Burkholderia thailandensis and some strains of Burkholderia cepacia also killed nematodes. Manipulation of the nematode host genotype suggests that the neuromuscular intoxication caused by both B. pseudomallei and B. thailandensis acts in part through a disruption of normal Ca2+ signal transduction. Both species produce a UV-sensitive, gamma-irradiation-resistant, limited diffusion, paralytic agent as part of their nematode pathogenic mechanism. The results of this investigation suggest that killing by B. pseudomallei is an active process in C. elegans, and that the C. elegans model might be useful for the identification of vertebrate animal virulence factors in B. pseudomallei.
Novel Serial Code Concatenation Strategies for Error Floor Mitigation of LDPC and TPC (2013)

Fil: Morero, Damian Alfonso. Universidad Nacional de Cordoba. Facultad de Ciencias Exactas, Fisicas y Naturales; Argentina;
Local release polymeric‐controlled immunotherapy of cardiac transplants in rats (1992)

Abstract Systemic immunosuppression frequently results in severe side effects. To evaluate a method of limiting the adverse effects of immunosuppression, we implanted controlled release matrices containing cyclosporine‐A (Cy) embedded (0.2 or 1 mg/kg/day released), steroid embedded (2%, 0.2% and 0.02% dexamethasone, Dex) or both (Cy 0.2 mg and Dex 0.2%) locally around the transplanted heart at the time of rat heterotopic (neck) heart transplants. Controls received empty (non‐drug) matrix implants. To elucidate a local effect, additional groups received Cy (0.2 mg) or Dex (0.2%) matrix implanted in a subdermal distal leg pouch at the time of heart transplant, without a local neck implant. Rejection was determined by the lack of transplanted heart contractions. Recipient animals received no other form of immunosuppression. The Cy (0.2 mg) animals had whole‐blood Cy levels monitored for 6 weeks following transplantation. Cy levels peaked at 7–10 days after transplant (119 ± 26 ng/ml) and decayed to &lt;50 ng/ml by day 42. At no time did whole‐blood Cy levels reach clinically significant levels. Additional animals had whole‐blood, heart and kidney Cy levels measured at day 6 post‐transplant. Both doses of local Cy demonstrated good survival benefit and were well absorbed locally, resulting in high Cy levels in heart tissue (&gt;9,000 ng/mg). Furthermore, while low‐dose Cy (0.2 mg) demonstrated significant survival benefit, these animals had clinically negligible blood Cy levels on day 6 (&lt;100 ng/ml) and very low kidney Cy levels. Interestingly, the lowest dose of Dex demonstrated no survival benefit, while the mid‐ and high‐Dex doses demonstrated good survival benefit: however, the high‐Dex dose had poor wound healing. Cy and Dex combination did not increase efficacy, perhaps due to release problems from physicochemical interactions. Local immunosuppression with a controlled release matrix resulted in a significant survival advantage and was effective in delaying rejection. This approach may prove advantageous clinically, in extending transplantation and lessening immunosuppression side effects.
Synthesis and Antiviral Evaluation of 2′,3′‐Dideoxy‐2′‐fluoro‐3′‐C‐hydroxymethyl‐β‐D‐arabinofuranosyl Pyrimidine Nucleosides (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Bacterial infections in patients with primary ciliary dyskinesia: Comparison with cystic fibrosis (2017)

Primary ciliary dyskinesia (PCD) is an autosomal recessive disorder associated with severely impaired mucociliary clearance caused by defects in ciliary structure and function. Although recurrent bacterial infection of the respiratory tract is one of the major clinical features of this disease, PCD airway microbiology is understudied. Despite the differences in pathophysiology, assumptions about respiratory tract infections in patients with PCD are often extrapolated from cystic fibrosis (CF) airway microbiology. This review aims to summarize the current understanding of bacterial infections in patients with PCD, including infections with Pseudomonas aeruginosa, Staphylococcus aureus, and Moraxella catarrhalis, as it relates to bacterial infections in patients with CF. Further, we will discuss current and potential future treatment strategies aimed at improving the care of patients with PCD suffering from recurring bacterial infections.
Parameter Extraction and Comparison of Self-Heating Models for Power MOSFETs Based on Transient Current Measurements (2012)

A self-heating parameter extraction method for a circuit simulation model is discussed based on the transient drain current measurement, by using an 18-V LDMOS as a test device. Important quantities for self-heating models, self-heating-free drain current, thermal resistance <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">R</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> , and thermal capacitance <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> are directly and simultaneously extracted from the transient current measurements. The method is efficient in improving the fitting quality in the short-time domain after switching and in guaranteeing the consistency among the extracted quantities. Based on the method, two kinds of thermal network are compared and discussed for the on-wafer measurement. It is demonstrated that the 1R1C model using the method carries fitting errors only in the narrow range of time and that the fitting errors can be removed only by adding one pair of thermal resistance and thermal capacitance which represent the thermal distribution below the device.
Update on the Pathfinder Project (2009)

This material is posted here with permission of the IEEE. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to pubs-permissions@ieee.org. By choosing to view this document, you agree to all provisions of the copyright laws protecting it. Update on the Pathfinder Project ∗
Endothelial Function Assessed by Automatic Measurement of Enclosed Zone Flow‐Mediated Vasodilation Using an Oscillometric Method Is an Independent Predictor of Cardiovascular Events (2016)

URL: https://upload.umin.ac.jp. Unique identifier: UMIN000004902.
Prostaglandin E2Produced by Alginate-Encapsulated Mesenchymal Stromal Cells Modulates the Astrocyte Inflammatory Response (2017)

Astroglia are well known for their role in propagating secondary injury following brain trauma. Modulation of this injury cascade, including inflammation, is essential to repair and recovery. Mesenchymal stromal cells (MSCs) have been demonstrated as trophic mediators in several models of secondary CNS injury, however, there has been varied success with the use of direct implantation due to a failure to persist at the injury site. To achieve sustained therapeutic benefit, we have encapsulated MSCs in alginate microspheres and evaluated the ability of these encapsulated MSCs to attenuate neuro-inflammation. In this study, astroglial cultures were administered lipopolysaccharide (LPS) to induce inflammation and immediately co-cultured with encapsulated or monolayer human MSCs. Cultures were assayed for the pro-inflammatory cytokine tumor necrosis factor alpha (TNF-<i>α</i>) produced by astroglia, MSC-produced prostaglandin E<sub>2</sub>, and expression of neurotrophin-associated genes. We found that encapsulated MSCs significantly reduced TNF-<i>α</i> produced by LPS-stimulated astrocytes, more effectively than monolayer MSCs, and this enhanced benefit commences earlier than that of monolayer MSCs. Furthermore, in support of previous findings, encapsulated MSCs constitutively produced high levels of PGE<sub>2</sub>, while monolayer MSCs required the presence of inflammatory stimuli to induce PGE<sub>2</sub> production. The early, constitutive presence of PGE<sub>2</sub> significantly reduced astrocyte-produced TNF-<i>α</i>, while delayed administration had no effect. Finally, MSC-produced PGE<sub>2</sub> was not only capable of modulating inflammation, but appears to have an additional role in stimulating astrocyte neurotrophin production. Overall, these results support the enhanced benefit of encapsulated MSC treatment, both in modulating the inflammatory response and providing neuroprotection.
Resolving Pitching Airfoil Transonic Aerodynamics by Computational Fluid Dynamics Data Modeling1 (2021)

Abstract A detailed numerical study of harmonically pitching airfoils of NACA00 series is presented here. Based on the analysis of the computational fluid dynamics (CFD) results, a hypothesis is made that a simple data model can capture the dynamics of the airfoils in pitch. The data model is based on the cl−α (lift coefficient–angle of attack) hysteresis loops that retain generic geometrical characteristics for a wide range of reduced frequency, k, encountered in flutter in transonic flows for all the NACA00 airfoils considered. The model was trained on a subset of the considered NACA00 airfoils and then tested on the remaining NACA00 set, for a subset of the reduced frequencies. The model predictions of the cl−α hysteresis loops for the test set are shown to be in excellent agreement with the CFD results for the range of k typical of transonic flutter. The data model offers a paradigm shift in the prediction of transonic flow dynamics of pitching airfoils and will guide the development of a new transfer function that will be incorporated in a new aeroelastic framework leading to an appropriate transonic flutter model for use in the development of future aircraft.
Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions. (2019)

The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson's disease. Native monomeric αSyn exists in an intrinsically disordered ensemble of interconverting conformations, which has made its therapeutic targeting by small molecules highly challenging. Nonetheless, here we successfully target the monomeric structural ensemble of αSyn and thereby identify novel drug-like small molecules that impact multiple pathogenic processes. Using a surface plasmon resonance high-throughput screen, in which monomeric αSyn is incubated with microchips arrayed with tethered compounds, we identified novel αSyn interacting drug-like compounds. Because these small molecules could impact a variety of αSyn forms present in the ensemble, we tested representative hits for impact on multiple αSyn malfunctions in vitro and in cells including aggregation and perturbation of vesicular dynamics. We thereby identified a compound that inhibits αSyn misfolding and is neuroprotective, multiple compounds that restore phagocytosis impaired by αSyn overexpression, and a compound blocking cellular transmission of αSyn. Our studies demonstrate that drug-like small molecules that interact with native αSyn can impact a variety of its pathological processes. Thus, targeting the intrinsically disordered ensemble of αSyn offers a unique approach to the development of small molecule research tools and therapeutics for Parkinson's disease.
VAST Clinical Trial: Safely Supplementing Tissue Lost to Degenerative Disc Disease (2020)

Initial assessments indicate that a 1-level or 2-level treatment offers a reliable intervention that is safe and beneficial.
Genetic determinants of responsiveness to mesenchymal stem cell injections in non-ischemic dilated cardiomyopathy (2019)

Our findings support the concept that the genetic profile of NIDCM patients plays a role in responsiveness to MSC therapy, with V- patients more likely to benefit and the converse for PV+. This observation emphasizes the need for further genetic studies, because of important implications for the management of NIDCM syndromes.
On Electrostatic Actuation Beyond Snapping Condition (2006)

Electrostatic parallel-plate actuators are a common way of actuating MEMS devices, both statically and dynamically. In the static case, the actuation range is limited to 1/3 of the initial actuation gap, known as the static pull-in condition. Under dynamic actuation conditions, however, the travel range can be much extended. This paper extends the analysis of pull-in instability to the dynamic case and derives the analytical AC dynamic pull-in condition. This condition predicts snapping or pull-in of the structure for a given domain of DC and AC actuation voltages versus quality factor. Analytical and experimental results are presented to validate the dynamic pull-in condition
Compression of Packed Particulate Systems: Simulations and Experiments in Graphitic Li-ion Anodes (2005)

Increased thermal conductivity, electronic conductivity, and reversible capacity (i.e., reduced irreversible capacity loss, or ICL) have been demonstrably achievable by compression of anodes into higher volume fraction plates, though excessive compression can impair Li-ion battery performance. In our previous study, we correlated conductivity and compression of these materials. Here, we further investigated the effects of friction and deformability of particles on the compressibility of model carbons of Li-ion anodes. First, we implemented a statistically unbiased technique for generating a range of random particulate systems, from permeable to impermeable arrangements, along with a contact model for randomly arranged triaxial ellipsoidal particles, suitable for implementation in finite element analysis of compression of a random, porous system. We then quantified the relationship between interfacial friction and jamming fraction in spherical to ellipsoidal systems and applied these models to correlate maximum stresses and different frictional coefficients, with morphology (obtained by image analysis) of graphite particles in Li-ion anodes. The simulated results were compared with the experiments, showing that the friction coefficient in the system is close to 0.1 and that the applied pressure above 200kg∕cm2(200MPa) can damage the materials in SL-20 electrodes. We also conclude that use of maximum jamming fractions to assess likely configuration of mixtures is unrealistic, at best, in real manufacturing processes. Particles change both their overall shapes and relative orientations during deformation sufficient to alter the composite properties: indeed, it is alteration of properties that motivates post-processing at all. Thus, consideration of material properties, or their estimation post facto, using inverse techniques, is clearly merited in composites having volume fractions of particles near percolation onset.