gebhart/patrepeval huggingface dataset:
Contrast-Induced Encephalopathy: A Rare Complication in a Patient on Peritoneal Dialysis with Several Risk Factors (2023)

Major adverse renal and cardiovascular events are reported for high-risk patients undergoing intra-arterial procedures, even if performed with iso-osmolar contrast media (CM). We report a case of contrast-induced encephalopathy (CIE) in a peritoneal dialysis (PD) patient, affected by diabetes, hypertension, and chronic heart failure. A 78-year-old PD patient (diuresis 1,000 mL) underwent a percutaneous angioplasty of the carotid. Immediately after the exam, he developed mental confusion and aphasia. Encephalic computed tomography scan and magnetic resonance imaging excluded ischemia or hemorrhage, but both showed cerebral edema; EEG showed right hemisphere abnormalities, sequelae of recent ischemia. Mannitol and steroids were administered to reduce edema, and additional PD exchange was performed with depurative aim. Within 2 days the patient completely recovered. CIE mimics severe neurological diseases, and it should be considered as differential diagnosis if symptoms come out soon after intra-arterial administration of CM, especially in high-risk patients. Our patient suffered from diabetes, chronic kidney disease, hypertension, chronic heart failure, which are possible contributing factors to the development of CIE. Moreover, this clinical scenario is noteworthy because the development in a patient who underwent PD had never been described before.
High Thermal Durability of Water-Free Copper-Octacyanotungsten-Based Magnets Containing Halogen Bonds (2011)

Two-dimensional (2-D) cyano-bridged Cu–W bimetallic assemblies that include halogen-substituted pyridine molecules, [CuII(3-iodopyridine)4][CuII(3-iodopyridine)2]2[WV(CN)8]2 (1) (triclinic crystal structure, P1̅ space group), [CuII(3-bromopyridine)4][CuII(3-bromopyridine)2]2[WV(CN)8]2 (2) (triclinic, P1̅), and [CuII(3-chloropyridine)2(H2O)2][CuII(3-chloropyridine)2]2[WV(CN)8]2·4H2O (3) (monoclinic, P21/c), were synthesized. Thermogravimetric measurements demonstrate that 1 and 2 have high thermal durability up to ca. 150 °C (423 K) due to the lack of water molecules in the crystal and the stacked Cu–W 2-D layers with halogen bonding between halogen-substituted pyridine and the cyano nitrogen of octacyanotungstate. In contrast, 3 exhibits weight loss above ca. 50 °C (323 K) as the water molecules between the 2-D layers are removed upon heating. Magnetic measurements show that 1–3 are ferromagnets due to parallel ordering of the magnetic spins on CuII (S = 1/2) and WV (S = 1/2) with Curie temperatures (TC) of 4.7 K (1), 5.2 K (2), and 7.2 K (3).
Physicochemical analysis of wheat flour fortified with vitamin A and three types of iron source and sensory analysis of bread using these flours (2013)

The findings suggest that dual fortified flour with high or even lower levels of vitamin A and iron could be considered for food fortification programmes to reduce the prevalence of micronutrient undernutrition of vitamin A and iron in developing countries.
Green‐Solvent‐Processed Molecular Solar Cells (2014)

High-efficiency bulk heterojunction (BHJ) organic solar cells with power conversion efficiencies of more than 5 % can be fabricated using the green solvent 2-MeTHF. The active layers comprise a blend of a molecular semiconductor donor with intermediate dimensions (X2) and the soluble fullerene derivative [6,6]-phenyl-C61 -butyricacidoctylester (PC61 BC8 ). A switch of the processing solvent from chloroform to 2-MeTHF leads to no negative impacts on the morphology and charge-transport properties of optimally performing BHJ films. Examinations by absorption spectroscopy, atomic force microscopy, and grazing incidence wide-angle X-ray scattering reveal no significant modification of morphology. These results show that green solvents can be excellent alternatives for large-area printing of high-performance organic photovoltaics (OPVs) and thus open new opportunities for sustainable mass production of organic solar cells and other optoelectronic devices.
Automated vector selection of SIVQ and parallel computing integration MATLABTM: Innovations supporting large-scale and high-throughput image analysis studies (2011)

The SIVQ algorithm is suitable for automated vector selection settings and high throughput computation.
Catalytic Insertion of Ethylene into Al−C Bonds with Pentamethylcyclopentadienyl−Chromium(III) Complexes (2001)

Addition of ethylene to mixtures of Cp*CrMe2(PMe3) (1) and excess methylaluminoxane (MAO), followed by aqueous workup of the resulting solutions, results in the formation of a distribution of odd-carbon alkanes. When B(C6F5)3 is added to 1, followed by THF, one obtains dark crystals. A single-crystal X-ray diffraction study revealed that the product of the reaction is [Cp*CrMe(PMe3)(THF)][MeB(C6F5)3] (2). Polyethylene is obtained when using 1 and 2 equiv of B(C6F5)3. The reaction of ethylene with a mixture of 1 + 2 B(C6F5)3 + 380 “AlMe3” produces a distribution of odd-carbon alkanes. If triethylaluminum is used, instead of trimethylaluminum, the product is a distribution of even-carbon alkanes. The product distribution shifts to lower molecular weight product, and lower activities are attained with increasing triethylaluminum concentration. Use of more dichoromethane instead of toluene or hexane increases the ethylene consumption. Triisobutylaluminum and trioctylaluminum result in considerably lower activities. A mechanism for the oligomerization of ethylene involving fast transmetalation reactions between chromium and aluminum is proposed.
Towards Multiphysics Modeling of Chlorine Dilution (2013)

Electrodes of Impressed Current Cathodic Protection systems used to inhibit corrosion of ship hulls, are areas where Chlorine is produced. It has been observed that certain concentrations of such oxidants can lead to the reduction or even reversal of the accumulation of biological fouling on ship hulls. In this paper a multiphysics modeling and simulation framework of such a process is developed and applied for a typical electrolytic cell. The framework is based on a coupled chemical reaction – electric currents – convection – diffusion and electromigration model aiming at providing transient solutions of the Chlorine species concentration in the volume of the cell. Finite element analysis results are presented for the relevant partial differential equations of the spatio-temporal evolution of the involved species and current density for the geometry of the electrolytic cell.
IFM receiver with two correlators (2003)

A novel approach to an instantaneous frequency measurement receiver simplifies the design by using less hardware. This design is an essential approach to building an IFM receiver with simultaneous signal capability. Delay lines and correlators are used to measure the frequency of the input signals. To achieve a wide input bandwidth with fine frequency resolution, the novel receiver uses only two delay lines. To simplify the design, the algorithm used is related to the Chinese remainder theorem, modified to guard against noise. The receiver will have a resolution of 1 MHz and a bandwidth of 500 MHz, although only two phase correlators need to be digitized.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Abstract 3877: Temporal Trends in Permanent Pacemaker Implantation: A Population-Based Cohort Study (2006)

Objective: To describe temporal trends in incidence and comorbidities of permanent pacemaker (PPM) implantation over the past 30 years. Methods: Using the resources of the Rochester Epidemiology Pr...
Amisulpride for the Rescue Treatment of Postoperative Nausea or Vomiting in Patients Failing Prophylaxis (2018)

A single 10-mg dose of intravenous amisulpride was safe and more effective than placebo at treating established postoperative nausea or vomiting in patients failing postoperative nausea or vomiting prophylaxis.
Improvementof Foreign-Protein Production in Aspergillus niger var. awamori by Constitutive Induction of the Unfolded-ProteinResponse (2003)

Unfolded-protein response (UPR) denotes the upregulation of endoplasmic reticulum (ER)-resident chaperone and foldase genes and numerous other genes involved in secretory functions during the accumulation of unfolded proteins into the ER. Overexpression of individual foldases and chaperones has been used in attempts to improve protein production in different production systems. We describe here a novel strategy to improve foreign-protein production. We show that the constitutive induction of the UPR pathway in Aspergillus niger var. awamori can be achieved by expressing the activated form of the transcription factor hacA. This induction enhances the production of Trametes versicolor laccase by up to sevenfold and of bovine preprochymosin by up to 2.8-fold in this biotechnically important fungus. The regulatory range of UPR was studied by analyzing the mRNA levels of novel A. niger var. awamori genes involved in different secretory functions. This revealed both similarities and differences to corresponding studies in Saccharomyces cerevisiae.
Optical loss reduction in high-index-contrast chalcogenide glass waveguides via thermal reflow (2010)

A thermal reflow technique is applied to high-index-contrast, sub-micron waveguides in As(2)S(3) chalcogenide glass to reduce the sidewall roughness and associated optical scattering loss. We show that the reflow process effectively decreases sidewall roughness of chalcogenide glass waveguides. A kinetic model is presented to quantitatively explain the sidewall roughness evolution during thermal reflow. Further, we develop a technique to calculate waveguide optical loss using the roughness evolution model, and predict the ultimate low loss limit in reflowed high-index-contrast glass waveguides. Up to 50% optical loss reduction after reflow treatment is experimentally observed, and the practical loss limiting factors are discussed.
Imaging patterns of intensity in topographically directed photolithography (2005)

This article describes a process that consists of embossing a bas-relief pattern into the surface of a layer of photoresist and flood illuminating the embossed resist; this process uses the topography of the resist to generate a pattern of optical intensity inside the resist layer. Development of embossed, illuminated (λ=365–436nm) photoresist yields structures as small as 70nm. Numerical solutions of the Fresnel integral are used to calculate the pattern of intensity of light in the photoresist layer. Numeric simulation of a nondiffusion-limited development process results in theoretical structures that correlate well with the structures generated experimentally.
A bacterial two‐hybrid system based on the twin‐arginine transporter pathway of E. coli (2007)

We have developed a bacterial two-hybrid system for the detection of interacting proteins that capitalizes on the folding quality control mechanism of the Twin Arginine Transporter (Tat) pathway. The Tat export pathway is responsible for the membrane translocation of folded proteins, including proteins consisting of more than one polypeptide, only one of which contains a signal peptide ("hitchhiker export"). Here, one protein (bait) is expressed as a fusion to a Tat signal peptide, whereas the second protein (prey) is fused to a protein reporter that can confer a phenotype only after export into the bacterial periplasmic space. Since the prey-reporter fusion lacks a signal peptide, it can only be exported as a complex with the bait-signal peptide fusion that is capable of targeting the Tat translocon. Using maltose-binding protein as a reporter, clones expressing interacting proteins can be grown on maltose minimal media or on MacConkey plates. In addition, we introduce the use of the cysteine disulfide oxidase DsbA as a reporter. Export of a signal peptide-prey:bait-DsbA complex into the periplasm allows complementation of dsbA(-) mutants and restores the formation of active alkaline phosphatase, which in turn can be detected by a chromogenic assay.
Immobilization techniques and biopolymer carriers (2018)

Various immobilization methods are expected to have a bright future in the field of pharmacy, medicine or industry. Production of immobilized enzymes mainly by CLEAs introduces a whole new level of biotransformations, where biocatalysts are highly purified and active. Improvement of CLEAs technology will certainly develop food and pharmaceutical industry. Another immobilization path is affinity binding, also focused on enzymes. Preparation of generic protocols for enzyme attachment will increase the sensitivity of this technology, as well as its simplicity. Biocatalyst re-usage will significantly decrease the costs. Immobilization in nanodelivery systems may shortly dominate the field of medical sciences. The vast problem of civilization diseases is the difficulty in medicaments administration, either due to the size of the drug or the inaccessibility of the treated site. Nanodelivery systems will overcome this issue, as they are able to carry drugs directly to their site of action. Cancer, Alzheimer’s disease or autoimmune disorders will become controllable. Finally, other immobilization methods are being engineered in order to provide systems with better interactions with GI wall. Carriers will be adjusted for the highest selectivity for mucosal wall, whereas viral and bacterial mechanisms of uptake will be incorporated into biocatalyst to ameliorate the physiology of absorption.
A compact-size packaged third-order harmonic tag for intraocular pressure (IOP) monitoring inside a mouse eye (2012)

This paper shows measurement of intraocular pressure (IOP) within a mouse eye. Three main challenges faced the development of a device for the measurement: the size of the mouse eye, the depth of the anterior chamber where the device will be implanted, and the maximum allowable incision size. These factors all limit the size of the device. In addition, a novel detection scheme is required which enables detection of changes in IOP with high resolution. This paper presents the fabrication process of an ultra-small size Parylene tag in which a micro-electromechanical systems (MEMS) capacitive pressure sensor is packaged with a self-expandable Nitinol antenna and a diode. From the device implanted inside the mouse eye, a resonance frequency shift of the third-order harmonic signal was detected with a sensitivity of approximately 1.5 MHz/mmHg at an 11.5 cm distance from the sensor as the pressure inside the mouse eye changed. This work thus shows the feasibility of IOP monitoring using the third order harmonic from a device implanted inside the mouse eye.
Palopuro Agroecolocial Symbiosis – Increasing sustainability in organic farming (2017)

Agroecological symbiosis (AES) enhances productivity in agriculture. A case study of the first AES in Finland indicated that productivity of on the organic crop farm could be increased by producing biogas from green manure leys, fallows, and other locally available biomasses. At the same time, the farm became a net-energy producer instead of being an energy consumer. Combining the food processing, crop production, energy production and closer interaction with consumers increase the overall sustainability of the local food system
Serving content with unknown demand (2014)

In this paper we look at content placement in the high-dimensional regime: there are n servers, and O(n) distinct types of content. Each server can store and serve O(1) types at any given time. Demands for these content types arrive, and have to be served in an online fashion; over time, there are a total of O(n) of these demands. We consider the algorithmic task of content placement: determining which types of content should be on which server at any given time, in the setting where the demand statistics (i.e. the relative popularity of each type of content) are not known a-priori, but have to be inferred from the very demands we are trying to satisfy. This is the high-dimensional regime because this scaling (everything being O(n)) prevents consistent estimation of demand statistics; it models many modern settings where large numbers of users, servers and videos/webpages interact in this way.
Orbit (2004)

Orbit was an optimizing compiler for T, a dialect of Scheme. Its aggressive use of CPS conversion, novel closure representations, and efficient code generation strategies made it the best compiler for a Scheme dialect at the time and for many years to come. The design of T and Orbit directly spawned six PhD theses and one Masters thesis, and influenced many other projects as well, including SML of New Jersey.
A metallotricycle: synthesis, one-electron reduction, and crystal structure of the thermally robust complex tris-o-xylidenetungsten(VI), [W(CH2C6H4CH2-o)3] (1981)

Reaction of [WCl4(O)] with excess of the di-Grignard reagent oC6H4(CH2MgCl)2 in tetrahydrofuran (thf) yields [W[graphic omitted]H2-o)3](1), a thermally robust, reversible one-electron-reducible complex, of quasi 3/m symmetry with the o-xylidene ligand planes aligned parallel to the molecular axis and unusually folded, with significant, and possibly stabilising, W–π interactions, as shown by its X-ray structure determination, the mean W–CαH2 and W–Cβ distances being 2·21 and 2·48 Å respectively.
Supplementary materials from Sorafenib and Quinacrine Target Anti-Apoptotic Protein MCL1: A Poor Prognostic Marker in Anaplastic Thyroid Cancer (ATC) (2023)

&lt;p&gt;Supplementary materials Material and Methods Supplemental Figure 1: Quantitative assessment of mRNA expression of Mcl-1, RelA and Stat3 in anaplastic thyroid carcinoma (ATC) cell lines and resected ATC's using qRT-PCR. Supplemental Figure 2: Expressions of NFï�«B-p65 and Stat3pY in ATC. Supplemental Figure 3: Assessment of medical and staining parameters relationship to the overall survival (OS) in the ATC cohort. Supplemental Figure 4: Meta analysis of previously published expression profiles on ATC's. Supplemental Figure 5: Model schematic displaying drug synergy from the drug combination of sorafenib/quinacrine through the targeting of expression of anti-apoptotic Mcl-1. Supplemental Figure 6: In vivo optical near-infrared (NIR) imaging of orthotopic xenografts of human ATC cells. Supplemental Figure 7: Serum chemistry indicates lack of apparent toxicity by the S/Q combination. Supplemental Figure 8: Hematology indicates lack of apparent toxicity by the S/Q combination. Supplemental Figure 9: Reduced surface occupancy of CD34-positive small vessel endothelium and VEGF-expression in 8505C tumor xenografts treated with the combination of sorafenib and quinacrine.&lt;/p&gt;
ICFSR Task Force Perspective on Biomarkers for Sarcopenia and Frailty (2020)

Biomarkers of frailty and sarcopenia are essential to advance the understanding of these conditions of aging and develop new diagnostic tools and effective treatments. The International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force - a group of academic and industry scientists from around the world -- met in February 2019 to discuss the current state of biomarker development for frailty and sarcopenia. The D3Cr dilution method, which assesses creatinine excretion as a biochemical measure of muscle mass, was suggested as a more accurate measure of functional muscle mass than assessment by dual energy x-ray absorptiometry (DXA). Proposed biomarkers of frailty include markers of inflammation, the hypothalamic-pituitary-adrenal (HPA) axis response to stress, altered glucose insulin dynamics, endocrine dysregulation, aging, and others, acknowledging the complex multisystem etiology that contributes to frailty. Lack of clarity regarding a regulatory pathway for biomarker development has hindered progress; however, there are currently several international efforts to develop such biomarkers as tools to improve the treatment of individuals presenting these conditions.
An RNA Binding Protein Promotes Axonal Integrity in Peripheral Neurons by Destabilizing REST (2014)

The RE1 Silencing Transcription Factor (REST) acts as a governor of the mature neuronal phenotype by repressing a large consortium of neuronal genes in non-neuronal cells. In the developing nervous system, REST is present in progenitors and downregulated at terminal differentiation to promote acquisition of mature neuronal phenotypes. Paradoxically, REST is still detected in some regions of the adult nervous system, but how REST levels are regulated, and whether REST can still repress neuronal genes, is not known. Here, we report that homeostatic levels of REST are maintained in mature peripheral neurons by a constitutive post-transcriptional mechanism. Specifically, using a three-hybrid genetic screen, we identify the RNA binding protein, ZFP36L2, associated previously only with female fertility and hematopoiesis, and show that it regulates REST mRNA stability. Dorsal root ganglia in Zfp36l2 knock-out mice, or wild-type ganglia expressing ZFP36L2 shRNA, show higher steady-state levels of Rest mRNA and protein, and extend thin and disintegrating axons. This phenotype is due, at least in part, to abnormally elevated REST levels in the ganglia because the axonal phenotype is attenuated by acute knockdown of REST in Zfp36l2 KO DRG explants. The higher REST levels result in lower levels of target genes, indicating that REST can still fine-tune gene expression through repression. Thus, REST levels are titrated in mature peripheral neurons, in part through a ZFP36L2-mediated post-transcriptional mechanism, with consequences for axonal integrity.
Antineoplastic Urinary Protein Inhibits Kaposi’s Sarcoma and Angiogenesis In Vitro and In Vivo (1999)

Kaposi's sarcoma (KS) is the most common tumor in human immunodeficiency virus infection and acquired immune deficiency syndrome. Recent clinical trials with human chorionic gonadotropin (hCG) prepared from early pregnancy urine have shown encouraging results in the resolution of KS lesions. A urinary protein with antitumor activity, ANUP (antineoplastic urinary protein), a dimer of 32 kD, has previously been shown to inhibit the growth of various tumor cell lines in vivo. It was thus studied for its activity in KS cell lines in vitro and in vivo to determine whether it could be a source of the anti-KS activity observed in hCG preparations. ANUP is a strong growth inhibitor for KS cell lines, but has little or no effect on fibroblast, aortic smooth muscle, T- and B-lymphocyte, and monocyte cell lines. ANUP also inhibited the proliferation of endothelial cell lines, suggesting that the in vitro effects were endothelial cell lineage-specific. However, ANUP antibodies did not block the inhibitory effect of certain commercial preparations of hCG, previously shown to be active in KS. Thus, the active protein in these commercial preparations of hCG may be distinct from ANUP. The antitumor activity of ANUP was further confirmed in a chicken allantoic membrane (CAM) assay in which vascular endothelial growth factor (VEGF) and beta fibroblast growth factor (bFGF)-induced angiogenesis was inhibited by ANUP in a dose-dependent manner. In vivo activity of ANUP was demonstrated in the murine model of KS, where ANUP inhibited tumor growth. ANUP is thus a potential candidate for development in the treatment of KS and other diseases in which angiogenesis plays an important role.