gebhart/patrepeval huggingface dataset:
Celecoxib Inhibits Ureteral Contractility and Prostanoid Release (2005)

No AccessJournal of UrologyUrological Survey: Urolithiasis, Endourology and Laparoscopy1 Aug 2005Celecoxib Inhibits Ureteral Contractility and Prostanoid Release Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000170973.68875.a0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Celecoxib Inhibits Ureteral Contractility and Prostanoid Release." The Journal of Urology, 174(2), p. 600 © 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 174Issue 2August 2005Page: 600 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.Metrics Author Information Ralph V. Clayman More articles by this author Expand All Advertisement PDF downloadLoading ...
Catalytic Routes for Direct Methane Conversion to Hydrocarbons and Hydrogen: Current State and Opportunities (2022)

Natural gas, the cleanest fossil fuel, is an abundant source of methane and expected to play an increasingly important role in powering the world’s economic growth over the energy transition of the coming decades. Methane has the potential to be a CO2-free feedstock to cogenerate hydrogen (H2) and added value “building-blocks” chemicals (e.g., olefins and aromatics) for petrochemistry. In this review, the two processes (i) the oxidative coupling of methane (OCM) for production of ethylene and (ii) the nonoxidative methane dehydroaromatization (MDA) producing hydrogen and benzene are discussed. Both routes convert methane directly into valuable products, an advantage over the several-steps syngas route. The performances of various a variety of catalysts reported during the last 25 years for OCM (MnNaW, La2O3, Li-MgO, etc.) and MDA (M/HZSM-5, M/TNU-9, M/IM-5, M/ITQ-2, M@SiO2, M@CeO2, TaH/SiO2, GaN/SBA15, single-site M@HZSM-5, bimetallic M-M′/HZSM-5, core–shell structures, M/Zr(SO4)2 with M = Mo, Fe, Pt) under similar reaction conditions are compared. The major drawbacks and the strategies used to mitigate the main challenges related with the performance of the catalysts in both OCM and MDA reactions are critically revealed. For instance, the overoxidation in the OCM is mitigated by optimizing of the operating conditions, using alternative oxidants, and the application of membrane reactor technology are discussed. In the MDA reaction, the major issue is the catalyst deactivation by coke formation and migration and sintering of metallic active phases. Strategies for robust catalysts, methods for mild coke removal, pretreatment under reductive atmosphere are presented. Approaches to improve aromatics yields over coke production by addition of promoters or co-feed reactants to the MDA catalysts are also discussed.
Recordings of a Loudspeaker Orchestra With Multichannel Microphone Arrays for the Evaluation of Spatial Audio Methods (2023)

For live broadcasting of speech, music, or other audio content, multichannel microphone array recordings of the sound field can be used to render and stream dynamic binaural signals in real time. For a comparative physical and perceptual evaluation of conceptually different binaural rendering techniques, recordings are needed in which all other factors affecting the sound (such as the sound radiation of the sources, the room acoustic environment, and the recording position) are kept constant. To provide such a recording, the sound field of an 18channel loudspeaker orchestra fed by anechoic recordings of a chamber orchestra was captured in two rooms with nine different receivers. In addition, impulse responses were recorded for each sound source and receiver. The anechoic audio signals, the full loudspeaker orchestra recordings, and all measured impulse responses are available with open access in the Spatially Oriented Format for Acoustics (SOFA 2.1, AES69-2022) format. The article presents the recording process and processing chain as well as the structure of the generated database.
High-pressure synthesis of the indirectly electron-doped iron pnictide superconductorSr1−xLaxFe2As2with maximumTc=22 K (2010)

Compounds of ${\text{Sr}}_{1\ensuremath{-}x}{\text{La}}_{x}{\text{Fe}}_{2}{\text{As}}_{2}$ were synthesized by solid-state reaction at 1273 K, under pressures of 2 or 3 GPa. The ${\text{Sr}}_{1\ensuremath{-}x}{\text{La}}_{x}{\text{Fe}}_{2}{\text{As}}_{2}$ phase was dominant up to $x=0.5$ and superconductivity was observed at $x\ensuremath{\ge}0.2$. A maximum critical temperature ${T}_{c}$ of 22 K and a maximum shielding volume fraction of $\ensuremath{\sim}70\mathrm{%}$ were obtained at $x=0.4$. This is the first experimental demonstration of electron-doped superconductivity in 122-type iron pnictides, where electrons were doped through aliovalent substitution at the site of the alkaline-earth metal. The optimal ${T}_{c}$ was slightly higher than that for the Co-doped (directly electron-doped) samples (19 K) and much lower than that for the hole-doped case (37 K). The bulk superconductivity range was narrower than that for the Co-substituted case and both ranges were much narrower than that for the hole-doped case. These observations revealed that differences in the electron-doping mode (direct or indirect) did not have a prominent effect on the optimal ${T}_{c}$ or superconductivity range, compared with differences in carrier polarity.
The c.-456_-453delCCTT affects protein translation by reducing reinitiation. (2015)

&lt;p&gt;Relative luciferase activity for the wild type and the mutants (c.-456_-453delCCTT, c.-469C&gt;T) 5′UTRs was measured in GH3 (A) and HeLa (B) cells. The effects of the 4 bp deletion on luciferase mRNA in HeLa and GH3 cells (C) and on p27&lt;sup&gt;KIP1&lt;/sup&gt; level in HEK293 cells (D) are shown. Panel E shows the presence of the chimeric product in HEK293 cells transfected with the double mutant construct (c.-456_-459delCCTT+c.-74insC), followed by substantial reduction of p27&lt;sup&gt;KIP1&lt;/sup&gt; expression, demonstrated by western blot. P-values were calculated using a two-tailed t-test. *p&lt;0,01; EV, empty vector; wt, wild type; error bars, standard deviation.&lt;/p&gt;
Antigenic structure of sperm whale myoglobin. I. Partition of specificities between antibodies reactive with peptides and native protein. (1982)

We have resolved anti-sperm whale Mb antibodies into two distinct populations: One population is reactive only with the native molecule, and the second is reaction with both Mb and peptide fragments. CNBr cleavage of sperm whale Mb yields three peptides: peptide I (1-55), peptide II (56-131), and peptide III (132-153). Immunoadsorbent columns made with these three peptides were used to fractionate antibody to sperm whale Mb. These columns cumulatively bind 60 to 70% of the total antibody present in the four sera studied (the amount of antibody bound by each peptide was proportional to its size). The remaining 30 to 40% of antibody could only bind specifically to an immunoadsorbent column of native Mb. This result indicates that not all antigenic determinants on the native Mb molecule are represented on peptide fragments.
ChemInform Abstract: α‐Oxoketenes ‐ Preparation and Chemistry (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Neurological manifestations of hereditary hemorrhagic telangiectasia (rendu‐osler‐weber disease): Report of 2 cases and review of the literature (1978)

Two cases of hereditary hemorrhagic telangiectasia (HHT) with neurological involvement are presented. One patient had multiple vascular malformations including telangiectasias of the brain, medulla, and spinal cord and a berry aneurysm of the internal carotid artery; she also had a large cerebellar abscess, presumably reflecting the presence of a pulmonary arteriovenous fistula. The second patient had an idiopathic subarachnoid hemorrhage. In more than 200 reported patients with HHT involving the nervous system, 61% had lesions seondary to a pulmonary arteriovenous fistula (cerebral hypoxemia, paradoxical and septic emboli, and brain abscess). The findings emphasize the need for early surgical correction of such fistulas. In 36% of the patients with neurological involvement and HHT, vascular malformations of the brain and spinal cord were documented, and in 3%, portal-systemic encephalopathy was noted. Multiple lesions were frequent. HHT should be considered a generalized vascular dysplasia (universal or systemic angiomatosis), and not simply a benign mucocutaneous disease.
DNA-based copy number analysis confirms genomic evolution of PDX models (2021)

Abstract We previously reported the genomic evolution of the copy number (CN) landscapes of patient-derived xenografts (PDXs) during their engraftment and passaging 1 . Woo et al. argue that the CN profiles of PDXs are highly conserved, and that the main conclusions of our paper are invalid due to our use of expression-based CN profiles 2 . Here, we reassess genomic evolution of PDXs using the DNA-based CN profiles reported by Woo et al. We find that the degree of genomic evolution in the DNA-based dataset of Woo et al. is similar to that which we had previously reported. While the overall Pearson’s correlation of CN profiles between primary tumors (PTs) and their derived PDXs is high (as reported in our original paper as well), a median of ~10% of the genome is differentially altered between PTs and PDXs across cohorts (range, 0% to 73% across all models). In 24% of the matched PT-PDX samples, over a quarter of the genome is differentially affected by CN alterations. Moreover, in matched analyses of PTs and their derived PDXs at multiple passages, later-passage PDXs are significantly less similar to their parental PTs than earlier-passage PDXs, indicative of genomic divergence. We conclude that genomic evolution of PDX models during model generation and propagation should not be dismissed, and that the phenotypic consequences of this evolution ought to be assessed in order to optimize the application of these valuable cancer models.
High-Density ReRAM Crossbar with Selector Device for Sneak Path Reduction (2019)

Memristive crossbar arrays are finding application in a wide range of operations such as memory, in-memory-computing, analog computing, etc. The crossbar performance is limited by a sneak path current, which limits the array size and negatively affects power and noise margin. In this paper, we present a synthesis of one selector and one Memristor device (1S1R) unit based on nonlinear resistive selector connected in series with bipolar Memristor (MR) element. The selector provides a gating function to the MR to reduce the sneak path current. The operation and performance of the MR and the selector devices have been verified individually and when serially connected. The MR cell measurements show good repeatability over multiple SET-RESET cycles with Von ~ 2.5 to 3 V, Roff/Ron ~ 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> and Voff ~ -0.6 to -1.5 V. The electrical parameters of the memristor cell have been extracted and correlated mathematically using the Voltage-Threshold Adaptive Model (VTEAM). Various array sizes ranging from 2 ×2 to 4,000×4,000 have been investigated using spice circuit simulator. The results show that the proposed configuration reduces the sneak path by 200 times when compared with a similar size array that does not use a selector device. Also, using the selector increases the crossbar read margin, device selectivity, and enables high memory array density up to 4k×\pmb4k compared to 512 x512 state of the art. The device allows relatively low voltage operation of 4V/1V (write/read) compared to 5V/2V reported in literature, which makes it attractive for low power applications.
Additive Manufacturing of Spiral Windings for a Pot-Core Constant-Flux Inductor (2019)

Constant-flux inductors (CFIs) are designed to have a more uniform flux density in the core for efficient use of the magnetic material and higher inductance density. However, these inductors generally require unique winding structures that are difficult to manufacture by conventional means. In this article, we applied a paste-extrusion 3-D printer to fabricate spiral windings with varying turn-by-turn widths to make a pot-core CFI. The printing speed and extrusion rate of the printer were optimized for a commercial silver paste to form the windings. The printed windings were sintered at 850 °C to get electrical conductivity approaching that of bulk silver. To form the magnetic core, a custom-made curable magnetic composite paste was used to encase the windings. After curing at 200 °C, the permeability of the magnetic material can reach over 35 with low core-loss density. A 1-μH pot-core CFI of 5 mm x 5 mm x 2 mm was designed, fabricated, and characterized for its inductance and quality factor versus frequency and inductance versus dc current.
Using Document Similarity Methods to create Parallel Datasets for Code\n Translation (2021)

Translating source code from one programming language to another is a\ncritical, time-consuming task in modernizing legacy applications and codebases.\nRecent work in this space has drawn inspiration from the software naturalness\nhypothesis by applying natural language processing techniques towards\nautomating the code translation task. However, due to the paucity of parallel\ndata in this domain, supervised techniques have only been applied to a limited\nset of popular programming languages. To bypass this limitation, unsupervised\nneural machine translation techniques have been proposed to learn code\ntranslation using only monolingual corpora. In this work, we propose to use\ndocument similarity methods to create noisy parallel datasets of code, thus\nenabling supervised techniques to be applied for automated code translation\nwithout having to rely on the availability or expensive curation of parallel\ncode datasets. We explore the noise tolerance of models trained on such\nautomatically-created datasets and show that these models perform comparably to\nmodels trained on ground truth for reasonable levels of noise. Finally, we\nexhibit the practical utility of the proposed method by creating parallel\ndatasets for languages beyond the ones explored in prior work, thus expanding\nthe set of programming languages for automated code translation.\n
The effects of electroporation buffer composition on cell viability and electro-transfection efficiency (2020)

Abstract Electroporation is an electro-physical, non-viral approach to perform DNA, RNA, and protein transfections of cells. Upon application of an electric field, the cell membrane is compromised, allowing the delivery of exogenous materials into cells. Cell viability and electro-transfection efficiency (eTE) are dependent on various experimental factors, including pulse waveform, vector concentration, cell type/density, and electroporation buffer properties. In this work, the effects of buffer composition on cell viability and eTE were systematically explored for plasmid DNA encoding green fluorescent protein following electroporation of 3T3 fibroblasts. A HEPES-based buffer was used in conjunction with various salts and sugars to modulate conductivity and osmolality, respectively. Pulse applications were chosen to maintain constant applied electrical energy (J) or total charge flux (C/m 2 ). The energy of the pulse application primarily dictated cell viability, with Mg 2+ -based buffers expanding the reversible electroporation range. The enhancement of viability with Mg 2+ -based buffers led to the hypothesis that this enhancement is due to ATPase activation via re-establishing ionic homeostasis. We show preliminary evidence for this mechanism by demonstrating that the enhanced viability is eliminated by introducing lidocaine, an ATPase inhibitor. However, Mg 2+ also hinders eTE compared to K + -based buffers. Collectively, the results demonstrate that the rational selection of pulsing conditions and buffer compositions are critical for the design of electroporation protocols to maximize viability and eTE.
Welcome (2010)

On behalf of the IVEC 2010 Program Committee and the Electron Devices Society (EDS) Technical Committee on Vacuum Electronics, I would like to welcome you to the 11th IEEE International Vacuum Electronics Conference (IVEC 2010). IVEC was created in 2000 by merging the US Power Tube Conference and the European Space Agency TWTA Workshop, and has expanded to a fully international conference. It is held every other year in the US, and in Europe and Asia, alternately, every fourth year. The conference focuses on vacuum electron devices and their applications. This year's meeting, sponsored by the IEEE EDS, will be at the Portola Hotel and Spa in the picturesque city of Monterey, California.
The CLONETS – Clock Network Services: Strategy and innovation for clock services over optical-fibre networks (2019)

Methods for long-distance time and frequency transfer over optical fibers have demonstrated excellent performances and are evolving rapidly. CLONETS is a European Union-funded coordination and support action intended to facilitate the vision of a sustainable, pan-European optical fiber network for precise time and frequency reference dissemination.
A contractile and counterbalancing adhesion system controls the 3D shape of crawling cells (2014)

How adherent and contractile systems coordinate to promote cell shape changes is unclear. Here, we define a counterbalanced adhesion/contraction model for cell shape control. Live-cell microscopy data showed a crucial role for a contractile meshwork at the top of the cell, which is composed of actin arcs and myosin IIA filaments. The contractile actin meshwork is organized like muscle sarcomeres, with repeating myosin II filaments separated by the actin bundling protein α-actinin, and is mechanically coupled to noncontractile dorsal actin fibers that run from top to bottom in the cell. When the meshwork contracts, it pulls the dorsal fibers away from the substrate. This pulling force is counterbalanced by the dorsal fibers' attachment to focal adhesions, causing the fibers to bend downward and flattening the cell. This model is likely to be relevant for understanding how cells configure themselves to complex surfaces, protrude into tight spaces, and generate three-dimensional forces on the growth substrate under both healthy and diseased conditions.
Fabrication-robust silicon photonic devices in standard sub-micron silicon-on-insulator processes (2022)

Perturbations to the effective refractive index from nanometer-scale fabrication variations in waveguide geometry plague high index-contrast photonic platforms; this includes the ubiquitous sub-micron silicon-on-insulator (SOI) process. Such variations are particularly troublesome for phase-sensitive devices, such as interferometers and resonators, which exhibit drastic changes in performance as a result of these fabrication-induced phase errors. In this Letter, we propose and experimentally demonstrate a design methodology for dramatically reducing device sensitivity to silicon width variations. We apply this methodology to a highly phase-sensitive device, the ring-assisted Mach-Zehnder interferometer (RAMZI), and show comparable performance and footprint to state-of-the-art devices, while substantially reducing stochastic phase errors from etch variations. This decrease in sensitivity is directly realized as energy savings by significantly reducing the required corrective thermal tuning power, providing a promising path toward ultra-energy-efficient large-scale silicon photonic circuits.
3D model search and pose estimation from single images using VIP features (2008)

This paper describes a method to efficiently search for 3D models in a city-scale database and to compute the camera poses from single query images. The proposed method matches SIFT features (from a single image) to viewpoint invariant patches (VIP) from a 3D model by warping the SIFT features approximately into the orthographic frame of the VIP features. This significantly increases the number of feature correspondences which results in a reliable and robust pose estimation. We also present a 3D model search tool that uses a visual word based search scheme to efficiently retrieve 3D models from large databases using individual query images. Together the 3D model search and the pose estimation represent a highly scalable and efficient city-scale localization system. The performance of the 3D model search and pose estimation is demonstrated on urban image data.
Carbon-11-methionine PET imaging of malignant melanoma. (1995)

PET imaging with 11C-methionine is an effective method for visualizing melanoma. It may also be useful in measuring tumor metabolic activity in vivo.
Critical Review of Advances in Engineering Nanomaterial Adsorbents for Metal Removal and Recovery from Water: Mechanism Identification and Engineering Design (2021)

Nanomaterial adsorbents (NAs) have shown promise to efficiently remove toxic metals from water, yet their practical use remains challenging. Limited understanding of adsorption mechanisms and scaling up evaluation are the two main obstacles. To fully realize the practical use of NAs for metal removal, we review the advanced tools and chemical principles to identify mechanisms, highlight the importance of adsorption capacity and kinetics on engineering design, and propose a systematic engineering scenario for full-scale NA implementation. Specifically, we provide in-depth insight for using density functional theory (DFT) and/or X-ray absorption fine structure (XAFS) to elucidate adsorption mechanisms in terms of active site verification and molecular interaction configuration. Furthermore, we discuss engineering issues for designing, scaling, and operating NA systems, including adsorption modeling, reactor selection, and NA regeneration, recovery, and disposal. This review also prioritizes research needs for (i) determining NA microstructure properties using DFT, XAFS, and machine learning and (ii) recovering NAs from treated water. Our critical review is expected to guide and advance the development of highly efficient NAs for engineering applications.
Anti-diabetic Activity of Oscarellin Isolated from Oscarella stillans in Zebrafish, a Model of Type 2 Diabetes (2017)

A new anthranilic acid derivative (1) was isolated from a Philippine sponge, Oscarella stillans (family Plakinidae. phylum Porifera, class Demospongiae, order Homosclerophorida) [1]. The structure of compound 1, named oscarellin, was determined as 2-amino-3-(3′-aminopropoxy)benzoic acid from spectral data, and confirmed by synthesis. We examined the anti-diabetic activity of compound 1 in zebrafish model for type 2 diabetes. The zebrafish model for type 2 diabetes was induced by exposure to excess insulin. Following exposure of excess insulin, the pancreatic islet size and fluorescence intensity were measured [2]. When compared to the insulin-treated group, the pancreatic islet size in oscarellin (1)-treated group was significantly increased at concentrations of 1 and 5µM. Glucose uptake was evaluated in zebrafish treated with compound 1 by detecting the uptake of 2-NBDG fluorescence within the pancreatic islets. Oscarellin (1)-treated group revealed significantly increased glucose uptake at concentration of 5µM. Compound 1 led to the recovery of pancreatic islet size and glucose uptake. In conclusion, oscarellin (1) possessed anti-diabetic activity for type 2.
Nutrient Intake and Food Use of Finnish Conscripts in Garrison, on Leave, and in Encampment Conditions (2009)

At garrison and encampment, nutrient intakes reached recommendations. In free time, conscripts favored energy-rich nutrient-poor foods, which warrants intervening and dietary education.