gebhart/patrepeval huggingface dataset:
Development of a Model for Predicting Modulus on Asphalt Pavements Using FWD Deflection Basins (2006)

A development of regression model for asphalt concrete pavements using Falling Weight Deflectometer deflections is presented in this paper. A backcalculation program based on layered elastic theory was used to generate the synthetic modulus database, which was used to generate 95% confidence intervals of modulus in each layer. Using deflection basins of FWD data used in developing this procedure were collected from Pavement Management System in flexible pavements. Assumptions of back-calculation are that one is 3 layered flexible pavement structure and another is depth to bedrock is finite. It is found that difference of between 95% confidence intervals and modulus ranges of other papers does not exist. So, the data of 95% confidence intervals in each layer was used to develop multiple regression models. Multiple regression equations of each layer were established by SPSS, package of Statics analysis. These models were proved by regression diagnostics, which include case analysis, multi-collinearity analysis, influence diagnostics and analysis of variance. And these models have higher degree of coefficient of determination than 0.75. So this models were applied to predict modulus of domestic asphalt concrete pavement at FWD field test.
A Novel 3-D Display that Presents Nearly Correct Focus Cues (2009)

Stereoscopic displays present different images to the two eyes and thereby create a compelling three-dimensional (3D) sensation. They are being developed for numerous applications including cinema, television, virtual prototyping, and medical imaging. However, stereoscopic displays cause perceptual distortions, performance decrements, and visual fatigue. These problems occur because some of the presented depth cues (i.e., perspective and binocular disparity) specify the intended 3D scene while focus cues (blur and accommodation) specify the fixed distance of the display itself. We have developed a stereoscopic display that circumvents these problems. It consists of a fast switchable lens synchronized to the display such that focus cues are nearly correct. The system has great potential for both basic vision research and display applications.
Potentiation by potassium iodide using TPPS4 for antimicrobial photodynamic inactivation (2018)

Potassium iodide can potentiate antimicrobial photodynamic inactivation (aPDI) of a broad-spectrum of microorganisms, producing many extra logs of killing. We compared two charged porphyrins, TPPS4 (thought to be anionic and not able to bind to Gram-negative bacteria) and TMPyP4 (considered cationic and well able to bind to bacteria). As expected TPPS4 + light did not kill Gram-negative Escherichia coli, but surprisingly when 100 mM KI was added, it was highly effective at mediating aPDI (eradication at 200 nM + 10 J/cm<sup>2</sup> of 415 nm light). TPPS4 was more effective than TMPyP4 in eradicating the Gram-positive bacteria, methicillin-resistant Staphylococcus aureus and the fungal yeast Candida albicans (regardless of KI). TPPS4 was also highly active against E. coli after a centrifugation step when KI was added, suggesting that the supposedly anionic porphyrin bound to bacteria and Candida. We conclude that TPPS4 behaves as if it has some cationic character in the presence of bacteria, which may be related to its supply from vendors in the form of a dihydrochloride salt.
Electromagnetic (EM) wave characteristics in GIS and measuring the EM wave leakage at the spacer aperture for partial discharge diagnosis (2007)

For the insulation diagnosis of gas-insulated switchgears, the UHF method, which detects electromagnetic wave (EM-wave) in the UHF band (300 MHz to several GHz) with little noise influence, has rapidly developed in recent years. The study in this paper has proposed the evaluation of the location of adhering metallic particles based on the theory of EM-wave propagation by only using the time-waveform information of the EM-wave emitted due to partial discharge, and also analyzed and studied the validity using the FD-TD method. As a result, the duration of the time-waveform differed with respect to the location of the adhering metallic particle, and this difference was caused by the difference in the relative electric field intensity at the tip of the metallic particle among EM-wave modes and the difference was more when the tank diameter was larger. Based on this result, the method for evaluating the location of metallic particle according the time-waveform was studied. In addition, the characteristics of the leakage EM-wave at the spacer aperture were analyzed, and based on the result obtained, two types of antennas, patch and waveguide slot antennas, achieving compactness and a high sensitivity were proposed
Ecogeographic Conditions Dramatically Affect Trans-Resveratrol and Other Major Phenolics’ Levels in Wine at a Semi-Arid Area (2022)

Grapevines are susceptible and responsive to their surrounding environment. Factors such as climate region and terroir are known to affect polyphenolic compounds in wine and therefore, its quality. The uniqueness of the terroir in Israel is the variety of soil types and the climatic conditions, ranging from Mediterranean to arid climates. Thus, understanding the effects of climate on grapevine performance in Israel may be a test case for the effect of climate change on grapevine at other areas in the future. First, we present a preliminary survey (2012-2014) in different climate zones and terroirs, which showed that <i>trans</i>-resveratrol concentrations in Merlot and Shiraz were high, while those of Cabernet Sauvignon were significantly lower. A further comprehensive countrywide survey (2016) of Merlot wines from 62 vineyards (53 wineries) compared several phenolic compounds' concentrations between five areas of different climate and terroir. Results show a connection between <i>trans-</i>resveratrol concentrations, variety, and terroir properties. Furthermore, we show that <i>trans-</i>resveratrol concentrations are strongly correlated to humidity levels at springtime, precipitation, and soil permeability. This work can be considered a glimpse into the possible alterations of wine composition in currently moderate-climate wine-growing areas.
Patterns of plant subcellular responses to successful oomycete infections reveal differences in host cell reprogramming and endocytic trafficking (2012)

Adapted filamentous pathogens such as the oomycetes Hyaloperonospora arabidopsidis (Hpa) and Phytophthora infestans (Pi) project specialized hyphae, the haustoria, inside living host cells for the suppression of host defence and acquisition of nutrients. Accommodation of haustoria requires reorganization of the host cell and the biogenesis of a novel host cell membrane, the extrahaustorial membrane (EHM), which envelops the haustorium separating the host cell from the pathogen. Here, we applied live-cell imaging of fluorescent-tagged proteins labelling a variety of membrane compartments and investigated the subcellular changes associated with accommodating oomycete haustoria in Arabidopsis and N. benthamiana. Plasma membrane-resident proteins differentially localized to the EHM. Likewise, secretory vesicles and endosomal compartments surrounded Hpa and Pi haustoria revealing differences between these two oomycetes, and suggesting a role for vesicle trafficking pathways for the pathogen-controlled biogenesis of the EHM. The latter is supported by enhanced susceptibility of mutants in endosome-mediated trafficking regulators. These observations point at host subcellular defences and specialization of the EHM in a pathogen-specific manner. Defence-associated haustorial encasements, a double-layered membrane that grows around mature haustoria, were frequently observed in Hpa interactions. Intriguingly, all tested plant proteins accumulated at Hpa haustorial encasements suggesting the general recruitment of default vesicle trafficking pathways to defend pathogen access. Altogether, our results show common requirements of subcellular changes associated with oomycete biotrophy, and highlight differences between two oomycete pathogens in reprogramming host cell vesicle trafficking for haustoria accommodation. This provides a framework for further dissection of the pathogen-triggered reprogramming of host subcellular changes.
TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage (2009)

TMP21 has been shown to be associated with the gamma-secretase complex and can specifically regulate gamma-cleavage without affecting epsilon-mediated proteolysis. To explore the basis of this activity, TMP21 modulation of gamma-secretase activity was investigated independent of epsilon-cleavage using an amyloid-beta precursor proteinepsilon (APPepsilon) construct which lacks the amyloid intracellular domain domain. The APPepsilon construct behaves similarly to the full-length precursor protein with respect to alpha- and beta-cleavages and is able to undergo normal gamma-processing. Co-expression of APPepsilon and TMP21 resulted in the accumulation of membrane-embedded higher molecular weight Abeta-positive fragments, consistent with an inhibition of gamma-secretase cleavage. The APPepsilon system was used to examine the functional domains of TMP21 through the investigation of a series of TMP21-p24a chimera proteins. It was found that chimeras containing the transmembrane domain bound to the gamma-secretase complex and could decrease gamma-secretase proteolytic processing. This was confirmed though investigation of a synthetic peptide corresponding to the TMP21 transmembrane helix. The isolated TMP21 TM peptide but not the homologous p24a domain was able to reduce Abeta production in a dose-dependent fashion. These observations suggest that the TMP21 transmembrane domain promotes its association with the presenilin complex that results in decreased gamma-cleavage activity.
Data from Validation of TPX2 as a Potential Therapeutic Target in Pancreatic Cancer Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; The targeting protein for Xklp2 (&lt;i&gt;TPX2&lt;/i&gt;) has recently gained attention as a putative oncogene possibly amplified in several human malignancies, including pancreatic adenocarcinoma. In this work, we sought to evaluate the copy number and expression of &lt;i&gt;TPX2&lt;/i&gt; in pancreatic cancer cell lines and tumor tissues and to further explore the potential of TPX2 as a therapeutic target.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; The DNA copy number and expression of the &lt;i&gt;TPX2&lt;/i&gt; gene were surveyed in pancreatic cancer cell lines and tumor tissues and compared with those of immortalized normal pancreatic ductal cells and normal pancreatic tissues. The cellular effects of TPX2 knockdown using small interfering RNA oligonucleotides in pancreatic cancer cells, such as growth in tissue culture, in soft agar, and in nude mice; apoptosis; and sensitivity to paclitaxel, were also investigated using various assays.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Low-copy-number &lt;i&gt;TPX2&lt;/i&gt; amplification was found in pancreatic cancer cell lines and low-passage pancreatic cancer tumor xenografts. TPX2 expression was upregulated in pancreatic cancer cell lines at both the mRNA and protein levels relative to the immortalized pancreatic ductal epithelial cell line HPDE6. Immunohistochemical staining of a tissue microarray showed that TPX2 expression was higher in pancreatic tumors compared with their normal counterparts. Treatment with TPX2 targeting small interfering RNAs effectively reduced pancreatic cancer cell growth in tissue culture, induced apoptosis, and inhibited growth in soft agar and in nude mice. Knockdown of TPX2 also sensitized pancreatic cancer cells to paclitaxel treatment.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our results suggest that TPX2 might be an attractive target for pancreatic cancer therapy. (Clin Cancer Res 2009;15(21):6519–28)&lt;/p&gt;&lt;/div&gt;
Design, Calibration, and Testing of an Automated Near-Infrared Liquid-Crystal Polarimetric Imaging System for Discrimination of Lung Cancer Cells (2015)

A newly developed tissue diagnostic method, based on label-free near-infrared (NIR) polarimetric reflectance imaging for the classification of histopathological samples of lung cancer cells, is presented. The design, calibration, and testing of an automated NIR polarimetric imaging system, with emphasis on lung cancer detection, are put forward in detail. The described electro-optical imaging polarimeter system exhibits high degree of accuracy and repeatability. The outcome of this paper indicates that the operational design principles of the NIR polarimetric system may be proved extremely useful in discrimination of label-free normal and lung cancer cell samples as well as differentiation of different lung cancer cells and stages in vitro.
Modification of the VSV Surface Pasteurizer to Treat the Visceral Cavity and Surfaces of Chicken Carcasses (2001)

ABSTRACT: Previous research with the VSV (vacuum/steam/vacuum) surface pasteurizer revealed the visceral cavity of chicken carcasses was not treated as effectively as the outside surface. The processor was modified to specifically treat the cavity by adding a mandrel assembly. Optimum process parameters were determined. Optimum process conditions were: initial vacuum 0.1s, final vacuum 0.5 s, vacuum absolute pressure of 4.1 to 7.1 kPa, steam time 0.1 s, and steam temperature 138 °C. Using carcasses inoculated with Listeria innocua and the whole bird rinse sampling procedure, bacteria kills were statistically significant at 0.7 to 0.8 log cfu/mL. Using deboned chicken breasts inoculated with L. innocua and the whole bird rinse sampling procedure, bacteria kills were statistically significant at 1.0 to 1.3 log cfu/mL.
TCPSpeaker (2010)

poster Share on TCPSpeaker: clean and dirty sides of the same slate Authors: Dan Levin Deutsche Telekom Labs/TU-Berlin Deutsche Telekom Labs/TU-BerlinView Profile , Harald Schioeberg Deutsche Telekom Labs/TU-Berlin Deutsche Telekom Labs/TU-BerlinView Profile , Ruben Merz Deutsche Telekom Labs/TU-Berlin Deutsche Telekom Labs/TU-BerlinView Profile , Cigdem Sengul Deutsche Telekom Labs/TU-Berlin Deutsche Telekom Labs/TU-BerlinView Profile Authors Info & Claims ACM SIGMOBILE Mobile Computing and Communications ReviewVolume 14Issue 4October 2010 pp 43–45https://doi.org/10.1145/1942268.1942284Online:22 November 2010Publication History 1citation69DownloadsMetricsTotal Citations1Total Downloads69Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Efficient Polymer Solar Cells (2013)

Presented on January 25, 2013 from 4:00 pm-5:00 pm in the Molecular Science and Engineering Building (MoSE) room G011.
ChemInform Abstract: VISIBLE‐LIGHT‐INDUCED OXYGEN GENERATION FROM AQUEOUS DISPERSONS OF TUNGSTEN(VI) OXIDE (1984)

Abstract Bei der O 2 ‐Erzeugung durch WO3‐Valenzbandlöcher [4h (WO 3 ) +2H,O‐ O3 + 4H 1 bewirkt die Gegenwart von Agtlonen als Akzeptoren für Leitungsbandelektronen (AgNO 3 ‐Lösung) eine höhere Quantenausb.
Use of a Conformational Switching Aptamer for Rapid and Specific Ex Vivo Identification of Central Nervous System Lymphoma in a Xenograft Model (2015)

Improved tools for providing specific intraoperative diagnoses could improve patient care. In neurosurgery, intraoperatively differentiating non-operative lesions such as CNS B-cell lymphoma from operative lesions can be challenging, often necessitating immunohistochemical (IHC) procedures which require up to 24-48 hours. Here, we evaluate the feasibility of generating rapid ex vivo specific labeling using a novel lymphoma-specific fluorescent switchable aptamer. Our B-cell lymphoma-specific switchable aptamer produced only low-level fluorescence in its unbound conformation and generated an 8-fold increase in fluorescence once bound to its target on CD20-positive lymphoma cells. The aptamer demonstrated strong binding to B-cell lymphoma cells within 15 minutes of incubation as observed by flow cytometry. We applied the switchable aptamer to ex vivo xenograft tissue harboring B-cell lymphoma and astrocytoma, and within one hour specific visual identification of lymphoma was routinely possible. In this proof-of-concept study in human cell culture and orthotopic xenografts, we conclude that a fluorescent switchable aptamer can provide rapid and specific labeling of B-cell lymphoma, and that developing aptamer-based labeling approaches could simplify tissue staining and drastically reduce time to histopathological diagnoses compared with IHC-based methods. We propose that switchable aptamers could enhance expeditious, accurate intraoperative decision-making.
Supplementary Figure 2 from Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis (2023)

&lt;p&gt;PDF file - 6297K, Supplemental Figure 2. Pancreatic histology in DKK1 mice on doxy; KC and KDC mice without doxy.&lt;/p&gt;
An Universal Active Power Filter Controller System (2009)

An universal active power filter controller system is proposed that adapts itself to both harmonic current source type loads as well as harmonic voltage source type loads is presented in this paper. The system level harmonic filtering application issues of a multiple and clustered harmonic producing load site, such as at an industrial load site or at a distribution substation, are addressed. Harmonic filtering solution for such sites is especially complicated because the overall site load characteristics can change from a harmonic current source type to a harmonic voltage source type load, depending on the operating point of the various individual loads. The proposed hybrid series active filter (HSAF) solution provides harmonic filtering for harmonic current source type load characteristics, and degrades controllably to a 'pure' series active filter (SAF) to provide harmonic filtering for harmonic voltage source type load characteristics. Both the HSAF and SAF are controlled by synchronous reference frame (SRF) controller. Field test results validate the adaptability and effectiveness of the proposed HSAF/SAF system for a 480 V, 750 kVA multiple and clustered load site.
ChemInform Abstract: Synthesis of Isoindolo[2,1‐a]indoles by the Palladium‐Catalyzed Annulation of Internal Alkynes. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Skewed caches from a low-power perspective (2005)

The common approach to reduce cache conflicts is to increase the associativity. From a dynamic power perspective this associativity comes at a high cost. In this paper we present miss ratio performance and a dynamic power comparison for set-associative caches, a skewed cache and also for a new organization proposed,the elbow cache. The elbow cache extends the skewed cache organization with a relocation strategy for conflicting blocks. We show that these skewed designs significantly reduce the conflict problems while consuming p to 56% less dynamic power than a comparably performing 8-way set associative cache. We believe this to be the strongest case in favor of skewed caches presented so far
Sensor Technology for Rate‐Adaptive Pacing and Hemodynamic Optimization (2021)

Rate-adaptive pacing has been a mainstay of bradycardia pacing programming for many years. The potential hemodynamic advantages of rate-adaptive modes have been recognized since very early in the rate-adaptive pacing experience. Rate-adaptive pacing may be similarly beneficial with cardiac resynchronization therapy (CRT) devices. An accelerometer incorporated into the tip of the pacing lead, originally known as “peak endocardial acceleration, was originally introduced for bradycardia pacing but is currently used in CRT devices for hemodynamic optimization. Even though some sensors may never have been clinically released as single-sensor rate-adaptive pacing systems, an iteration of the sensor technology could potentially be beneficial for hemodynamic autoregulation in CRT or stand-alone implantable diagnostic devices. The Sensor and Quality of Life study assessed the effect of single-sensor, minute ventilation, or accelerometer vs. dual-sensor programming on quality of life.
Plasma contains ultrashort single-stranded DNA in addition to nucleosomal cell-free DNA (2022)

Plasma cell-free DNA is being widely explored as a biomarker for clinical screening. Currently, methods are optimized for the extraction and detection of double-stranded mononucleosomal cell-free DNA of ∼160bp in length. We introduce uscfDNA-seq, a single-stranded cell-free DNA next-generation sequencing pipeline, which bypasses previous limitations to reveal a population of ultrashort single-stranded cell-free DNA in human plasma. This species has a modal size of 50nt and is distinctly separate from mononucleosomal cell-free DNA. Treatment with single-stranded and double-stranded specific nucleases suggests that ultrashort cell-free DNA is primarily single-stranded. It is distributed evenly across chromosomes and has a similar distribution profile over functional elements as the genome, albeit with an enrichment over promoters, exons, and introns, which may be suggestive of a terminal state of genome degradation. The examination of this cfDNA species could reveal new features of cell death pathways or it can be used for cell-free DNA biomarker discovery.
Conditional Mutagenesis of the Genome Using Site-Specific DNA Recombination: Figure 1. (2007)

INTRODUCTIONAltering the genome of intact cells and organisms by site-specific DNA recombination has become an important gene-transfer methodology. DNA modifications produced by gene transfer and homologous recombination are typically static once integrated among target cell chromosomes. In contrast, the inclusion of exogenous recombinase target sequences within transferred DNA segments allows subsequent modifications to previously altered genomic structure that increase the utility of gene transfer and enhance experimental design. Creating tissue- and cell-type-specific genetic lesions in animal models, indelibly marking progenitors for cell fate mapping, inducing large-scale chromosomal rearrangements, and complementing gene defects in studies of phenotypic maintenance and reversion are all possible by directing recombinase expression using gene transfer among experimentally modified genomes. Moreover, this approach is effective in providing controlled data establishing genotype-phenotype relationships and allows for the excision of introduced marker genes that can affect neighboring chromatin structure and function. Although early work involved the yeast Flp recombinase, most studies in mammalian systems have used the Cre recombinase derived from bacteriophage P1. Both enzymes are members of the integrase family of recombinases but bind to distinct DNA target signals. Cre recombinase operates on the 34-bp loxP sequence and, like Flp, performs conservative recombination involving DNA segments positioned among these target sites.