gebhart/patrepeval huggingface dataset:
Murine γ-Herpesvirus 68 Latency Protein M2 Binds to Vav Signaling Proteins and Inhibits B-cell Receptor-induced Cell Cycle Arrest and Apoptosis in WEHI-231 B Cells (2005)

The MHV-68 latent protein, M2, does not have homology to any known viral or cellular proteins, and its function is unclear. To define the role played by M2 during MHV-68 latency as well as the molecular mechanism involved, we used M2 as bait to screen a yeast two-hybrid mouse B-cell cDNA library. Vav1 was identified as an M2-interacting protein in two independent screenings. Subsequent yeast two-hybrid interaction studies showed that M2 also binds to Vav2, but not Vav3, and that three "PXXP" motifs located at the C terminus of M2 are important for this interaction. The interactions between M2 and Vav proteins were also confirmed in vivo in 293T and WEHI-231 B-cells by co-immunoprecipitation assays. Rac1/GST-PAK "pull-down" experiments and Western blot analysis using a phospho-Vav antibody demonstrated that expression of M2 in WEHI-231 cells enhances Vav activity. We further showed in WEHI-231 cells that M2 expression promotes proliferation and survival and is associated with enhanced cyclin D2 and repressed p27(Kip1), p130, and Bim expression. Taken together, these experiments suggest that M2 might have an important role in disseminating the latent virus during the establishment and maintenance of latency by modulating B-cell receptor-mediated signaling events through Vav to promote B-cell activation, proliferation, and survival.
ChemInform Abstract: Green Organic Synthesis in Ionic Liquids (2011)

Abstract Review: 131 refs.
Preparation of Aluminum Borate Whisker Reinforced Magnesium Alloy Composites by Semi-Solid Process (2019)

To develop a new kind of composite material, “the gradated morphology MMCs”, a semi-solid magnesium alloy was squeeze-cast into an aluminum borate whisker preform. Currently, to increase the interfacial tensile/shear strength between MMCs and some metal parts, the joining processes have been studied. However, a suitable process has not yet been found. In this study, we first studied the optimum manufacturing condition to increase the preform compressive strength which should be necessary to prevent the preform from deformation in the squeeze cast process. The dependence of the binder types, which were the SiO2, Al2O3 and TiO2 sols, the binder content (0~5 mass% vs. whisker amount) and the sintering temperature (1000~1160 °C) on the strength of the preform were measured. We then examined the microstructure of the obtained material which was in-situ joined with the semi-solid magnesium alloy (Mg-9 mass%Al-l mass%Zn). The results are as follows. (1) The SiO2 sol was the most effective as a binder to increase the preform compressive strength. (2) During the squeeze cast process, the particles of the α-Mg solid phase in the semi-solid alloy were filtered by the preform and piled up in front of the preform/semi-solid alloy interface. This causes a gradational distribution of the primaries in part of the obtained material.
Incentives for the key stakeholders in the hybrid use of the UHF broadcasting spectrum utilizing Supplemental Downlink: A dynamic capabilities view (2014)

This paper investigates key stakeholders’ incentives for the hybrid use of the UHF spectrum for broadcasting and mobile broadband using novel Supplemental Downlink (SDL) Carrier Aggregation (CA) technique from the dynamic capabilities perspective of strategic management. So far broadcaster (BC) comm
Cigarette Smoking, Alcohol and Cannabis Use in Patients With Pervasive Developmental Disorders (2016)

PDD is associated with 5-8-fold lower adjusted risk of smoking, alcohol and cannabis use compared to other non-psychotic psychiatric patients. Further research should elucidate the neurobiological and psychosocial mechanisms underlying the apparent addiction protective properties of PDD.
Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes (2016)

Metabolism of PQ showed enantioselectivity. These findings may provide important information in establishing clinical differences in PQ enantiomers.
Transient 2D paper web drying model based on CFD (2009)

In the present article, a model combining the benefits of the small scale and large scale approaches towards modeling paper drying in a paper machine dryer section environment is described. The model is transient and two-dimensional, taking into account the MD and the thickness directions but neglecting the phenomena in the CD direction.
Accumulation of Latex in Peyer's Patches and Its Subsequent Appearance in Villi and Mesenteric Lymph Nodes (1978)

SummaryLatex particles (2 μm in diameter) accumulated in intestinal Peyer's patches and mesenteric lymph nodes of mice given latex suspensions as drinking fluid. After a 61-day period of latex feeding, the particles were also present in villi adjacent to Peyer's patches; they were not seen, however, after only 3 days of latex feeding. The amount of latex in Peyer's patches 74 days after the termination of latex feeding was much less than the amount present 14 days after the termination of feeding. It is suggested that migratory macrophages take up latex particles within Peyer's patches and subsequently move out of the patch to mesenteric nodes and villi. Some free particles may also be transported out of Peyer's patches to mesenteric nodes and villi through open lymphatic channels. The observations support the contention that Peyer's patches "sample" intestinal contents and they suggest a mechanism for the elimination of accumulated inert particulate matter from these lymphoid structures.
First‐in‐human study with ACT‐1014‐6470, a novel oral complement factor 5a receptor 1 (C5aR1) antagonist, supported by pharmacokinetic predictions from animals to patients (2022)

Aberrantly controlled activation of the complement system contributes to inflammatory diseases. Safety, tolerability, and pharmacokinetics of single-ascending doses of ACT-1014-6470, a novel orally available complement factor 5a receptor 1 antagonist, were assessed in a randomized, double-blind, placebo-controlled Phase 1 study. Six ACT-1014-6470 doses (0.5-200 mg) were selected after predictions from a Complex Dedrick plot. In each group, ACT-1014-6470 or matching placebo was administered to six and two healthy male individuals under fed conditions, respectively, including a cross-over part with 10 mg administered also under fasted conditions. Pharmacokinetic blood sampling and safety assessments (adverse events, clinical laboratory, vital signs, 12-lead electrocardiogram, and QT telemetry) were performed. ACT-1014-6470 was absorbed with a time to maximum plasma concentration (t<sub>max</sub> ) of 3 h across dose levels and eliminated with a terminal half-life of 30-46 h at doses ≥ 2.5 mg. Exposure increased approximately dose proportionally. Under fed compared to fasted conditions, ACT-1014-6470 exposure was 2.2-fold higher and t<sub>max</sub> delayed by 1.5 h. Pharmacokinetic modelling predicted that twice-daily oral administration is warranted in a subsequent multiple-dose study. No clinically relevant findings were observed in safety assessments. ACT-1014-6470 was well tolerated at all doses and could provide a novel therapy with more patient-friendly administration route compared to biologicals.
Spectrum access models and auction mechanisms (2012)

The demand for spectrum is growing rapidly as data intensive mobile communications and high-definition television are getting more popular. The spectrum regulators are preparing for flexible spectrum use and the implementation of new technologies. To make the appropriate decisions, the regulators need to identify and evaluate the different alternatives. In this paper, we examine a systematic classification of the spectrum access models that can be used together with suitable auctions in order to evaluate and decide between the different models. The basic idea of the taxonomy is to distinguish the different forms of spectrum sharing. For example, multiple systems may coexist in the same frequency band so that the low priority systems may transmit only if the high priority systems are not occupying the band. The hierarchy of the systems can be implemented by using a variety of technologies like centralized databases or distributed sensing devices. The taxonomy clarifies the regulatory alternatives and highlights the differences in ownership and usage rights. We also discuss how to incorporate the new spectrum access models in the auction design and how to support spectrum management using economic modeling and mechanism design framework.
A Decade of Friction Stir Welding R and D at NASA's Marshall Space Flight Center and a Glance into the Future (2006)

Welding at NASA's Marshall Space Flight Center (MSFC), Huntsville, Alabama, has taken a new direction through the last 10 years. Fusion welding processes, namely variable polarity plasma arc (VPPA) and tungsten inert gas (TIG) were once the corner stone of welding development in the Space Flight Center's welding laboratories, located in the part of MSFC know as National Center for Advanced Manufacturing (NCM). Developed specifically to support the Shuttle Program's External Tank and later International Space Station manufacturing programs, was viewed as the paragon of welding processes for joining aluminum alloys. Much has changed since 1994, however, when NASA's Jeff Ding brought the FSW process to the NASA agency. Although, at that time, FSW was little more than a lab curiosity, NASA researchers started investigating where the FSW process would best fit NASA manufacturing programs. A laboratory FSW system was procured and the first welds were made in fall of 1995. The small initial investment NASA made into the first FSW system has certainly paid off for the NASA agency in terms of cost savings, hardware quality and notoriety. FSW is now a part of Shuttle External Tank (ET) production and the preferred weld process for the manufacturing of components for the new Crew Launch Vehicle (CLV) and Heavy Lift Launch Vehicle (HLLV) that will take this country back to the moon. It is one of the solid state welding processes being considered for on-orbit space welding and repair, and is of considerable interest for Department of Defense @OD) manufacturing programs. MSFC involvement in these and other programs makes NASA a driving force in this country's development of FSW and other solid state welding technologies. Now, a decade later, almost the entire on-going welding R&D at MSFC now focuses on FSW and other more advanced solid state welding processes.
Electrically tunable lens based on a dual-frequency nematic liquid crystal (2006)

We report on an electrically controlled liquid-crystal-based variable optical lens filled with a dual-frequency nematic material. The lens design employs a hole-patterned electrode structure in a flat nematic cell. In order to decrease the lens switching time we maximize the dielectric torque by using a dual-frequency nematic material that is aligned at an angle approximately 45 degrees with respect to the bounding plates by obliquely deposited SiO(x), and by using an overdrive scheme of electrical switching. Depending on the frequency of the applied field, the director realigns either toward the homeotropic state (perpendicular to the substrates) or toward the planar state (parallel to the substrates), which allows one to control not only the absolute value of the focal length but also its sign. Optical performance of the liquid-crystal lens is close to that of an ideal thin lens.
Comparison of a Novel Radially Dilating Balloon Ureteral Access Sheath to a Conventional Sheath in the Porcine Model (2008)

The novel balloon expandable ureteral access sheath had easier insertion and a better flow rate, and caused less urothelial trauma in this porcine model. This ureteral access sheath offers a promising new option for ureteral access. A randomized clinical trial is in progress to assess the benefits of this new ureteral access sheath.
Micropyramid-patterned, oxygen-permeable bottomed dish for high density culture of pancreatic islets (2022)

The need for maintaining cell-spheroid viability and function within high-density cultures is unmet for various clinical and experimental applications, including cell therapies. One immediate application is for transplantation of pancreatic islets, a clinically recognized treatment option to cure type 1 diabetes; islets are isolated from a donor for subsequent culture prior to transplantation. However, high seeding conditions cause unsolicited fusion of multiple spheroids, thereby limiting oxygen diffusion to induce hypoxic cell death. Here we introduce a culture dish incorporating a micropyramid-patterned surface to prevent the unsolicited fusion and oxygen-permeable bottom for optimal oxygen environment. A 400<i>µ</i>m-thick, oxygen-permeable polydimethylsiloxane sheet topped with micropyramid pattern of 400<i>µ</i>m-base and 200<i>µ</i>m-height was fabricated to apply to the 24-well plate format. The micropyramid pattern separated the individual pancreatic islets to prevent the fusion of multiple islets. This platform supported the high oxygen demand of islets at high seeding density at 260 islet equivalents cm<sup>-2</sup>, a 2-3-fold higher seeding density compared to the conventional islet culture used in a preparation for the clinical islet transplantations, demonstrating improved islet morphology, metabolism and function in a 4 d-culture. Transplantation of these islets into immunodeficient diabetic mice exhibited significantly improved engraftment to achieve euglycemia compared to islets cultured in the conventional culture wells. Collectively, this simple design modification allows for high-density cultures of three-dimensional cell spheroids to improve the viability and function for an array of investigational and clinical replacement tissues.
The Use of Absorbable Mesh in Implant-Based Breast Reconstruction: A 7-Year Review (2020)

Therapeutic, IV.
Design and synthesis of an achiral ferroelectric smectic liquid crystal (2011)

Design and synthesis of a bent-core mesogen possessing the achiral ferroelectric SmAP<sub>F</sub> phase is reported. The design approach is based upon the discovery of Sadashiva and Reddy, et al. that bent-core mesogens possessing only one tail gave biaxial SmA phases shown to be antiferroelectric (SmAP<sub>A</sub>). The SmAP<sub>A</sub> phase shows antiferroelectric layer stacking with synclinic layer interfaces, as expected based upon typical behavior seen in most bent-core mesogens. In order to obtain the target ferroelectric phase, several tails known to allow the formation of anticlinic layer interfaces were incorporated into the basic Sadashiva/Reddy structure. These tails are thought to suppress out of layer fluctuations, thereby removing the strong entropically driven tendency for synclinic layer interfaces, and allowing formation of anticlinic layer stacking driven by a more subtle, and unknown, factor in the free energy of the system. In the event, the tricarbosilane-terminated alkoxy tail proved effective, providing the first known low molar mass SmAP<sub>F</sub> material.
Decreased tissue stiffness in glioblastoma by MR elastography is associated with increased cerebral blood flow (2021)

The inclusion of MRE measurements in statistical models helped predict perfusion, with stiffer tissue associated with lower perfusion values.
Millimeter-wave power amplifier module using redistribution layer technology (2012)

This paper presents a 77-GHz band high-power CMOS amplifier module. In an effort to integrate MMIC with low-loss passive circuits, multi-layered redistribution layer (RDL) technology has been installed. Passive circuits made using RDL technology and 65-nm CMOS circuits are enabling breakthrough approaches for millimeter wave applications. Low-loss passive circuits using RDL technology was fabricated. Moreover, we developed an amplifier module combining four identical CMOS power amplifiers with RDL Wilkinson power combiner to increase the output power. The saturation power of the amplifier module exhibits 15 dBm, which is 6 dB higher than that of the single PA.
Method for preventing micromechanical structures from adhering to another object (2023)

A method for preventing micromechanical structures from adhering to another object includes the step of immersing a micromechanical structure and its associated substrate in a chemical species that does not stick to itself. The method can be employed during the manufacture of micromechanical structures to prevent micromechanical parts from sticking or adhering to one another and their associated substrate surface.
The concept and application of antisense oligonucleotides (2001)

Since the identification of the double-stranded DNA helix by Watson and Crick in 1953, the knowledge of nucleotide structure and function has been an important potential tool in the study and therapy of disease. There is recent clinical evidence that antisense oligonucleotides may be important therapeutic compounds in the clinical therapy of a range of diseases, including infection (viruses and bacteria), oncology, and inflammation. Our laboratory-based understanding of antisense oligonucleotide activity has provided a foundation for their use in several human diseases. Potentially relevant applications include inflammatory bowel disease therapy, psoriasis, transplantation, rheumatoid arthritis, cytomegalovirus retinitis, hepatitis C, and solid tumor therapy. Here we will outline these applications as well as our ongoing clinical trials for Crohn's disease.
Evaluation of new sesquiterpene quinones from two Dysidea sponge species as inhibitors of protein tyrosine kinase (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvaluation of new sesquiterpene quinones from two Dysidea sponge species as inhibitors of protein tyrosine kinaseK. A. Alvi, Maria Cristina Diaz, Phillip Crews, Doris L. Slate, Rita H. Lee, and Robert MorettiCite this: J. Org. Chem. 1992, 57, 24, 6604–6607Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://doi.org/10.1021/jo00050a043RIGHTS & PERMISSIONSArticle Views363Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (567 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Exchange-Coupled SmCo₅/Fe Nanocomposite Magnet Prepared by Low Oxygen Powder Metallurgy Process (2021)

In order to realize an anisotropic bulk nanocomposite (NC) magnet, anisotropic SmCo <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> powder and Fe nanopowder were prepared by a low oxygen powder metallurgy process. Single-phase SmCo <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> powder was obtained by an arc melting and jet milling process. Spherical Fe nanopowder with an average particle size of 98 nm was prepared by the low oxygen-induction thermal plasma (LO-ITP) process. Magnetic measurements showed the anisotropic behavior of the SmCo <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> powder and coercivity of 1 MA/m. The sintered SmCo <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> /Fe NC magnet displayed the nonlinear spring-back curves, indicating the exchange coupling effect in this NC magnet. Very thin Fe areas were observed between the SmCo <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> grains when non-oxidized Fe nanoparticles were added, and it is assumed that effective exchange coupling was induced in these ideal microstructures. This work proposed the potential of an anisotropic hard magnetic powder prepared by jet milling, and nano-sized soft magnetic particles were prepared by the LO-ITP process for improving the magnetic properties of the anisotropic NC bulk magnet.
Kilohertz waveforms optimized to produce closed-state Na+ channel inactivation eliminate onset response in nerve conduction block (2020)

The delivery of kilohertz frequency alternating current (KHFAC) generates rapid, controlled, and reversible conduction block in motor, sensory, and autonomic nerves, but causes transient activation of action potentials at the onset of the blocking current. We implemented a novel engineering optimization approach to design blocking waveforms that eliminated the onset response by moving voltage-gated Na+ channels (VGSCs) to closed-state inactivation (CSI) without first opening. We used computational models and particle swarm optimization (PSO) to design a charge-balanced 10 kHz biphasic current waveform that produced conduction block without onset firing in peripheral axons at specific locations and with specific diameters. The results indicate that it is possible to achieve onset-free KHFAC nerve block by causing CSI of VGSCs. Our novel approach for designing blocking waveforms and the resulting waveform may have utility in clinical applications of conduction block of peripheral nerve hyperactivity, for example in pain and spasticity.
Integrating In Silico Resources to Map a Signaling Network (2013)

The abundance of publicly available life science databases offers a wealth of information that can support interpretation of experimentally derived data and greatly enhance hypothesis generation. Protein interaction and functional networks are not simply new renditions of existing data: they provide the opportunity to gain insights into the specific physical and functional role a protein plays as part of the biological system. In this chapter, we describe different in silico tools that can quickly and conveniently retrieve data from existing data repositories and we discuss how the available tools are best utilized for different purposes. While emphasizing protein-protein interaction databases (e.g., BioGrid and IntAct), we also introduce metasearch platforms such as STRING and GeneMANIA, pathway databases (e.g., BioCarta and Pathway Commons), text mining approaches (e.g., PubMed and Chilibot), and resources for drug-protein interactions, genetic information for model organisms and gene expression information based on microarray data mining. Furthermore, we provide a simple step-by-step protocol for building customized protein-protein interaction networks in Cytoscape, a powerful network assembly and visualization program, integrating data retrieved from these various databases. As we illustrate, generation of composite interaction networks enables investigators to extract significantly more information about a given biological system than utilization of a single database or sole reliance on primary literature.