gebhart/patrepeval huggingface dataset:
A Wireless Passive Sensing System for Displacement/Strain Measurement in Reinforced Concrete Members (2016)

In this study, we show a wireless passive sensing system embedded in a reinforced concrete member successfully being employed for the measurement of relative displacement and strain in a simply supported beam experiment. The system utilizes electromagnetic coupling between the transceiver antenna located outside the beam, and the sensing probes placed on the reinforcing bar (rebar) surface inside the beam. The probes were designed in the form of a nested split-ring resonator, a metamaterial-based structure chosen for its compact size and high sensitivity/resolution, which is at µm/microstrains level. Experiments were performed in both the elastic and plastic deformation cases of steel rebars, and the sensing system was demonstrated to acquire telemetric data in both cases. The wireless measurement results from multiple probes are compared with the data obtained from the strain gages, and an excellent agreement is observed. A discrete time measurement where the system records data at different force levels is also shown. Practical issues regarding the placement of the sensors and accurate recording of data are discussed. The proposed sensing technology is demonstrated to be a good candidate for wireless structural health monitoring (SHM) of reinforced concrete members by its high sensitivity and wide dynamic range.
A Cross-Sectional Study of Bone Nanomechanics in Hip Fracture and Aging (2023)

Bone mechanics is well understood at every length scale except the nano-level. We aimed to investigate the relationship between bone nanoscale and tissue-level mechanics experimentally. We tested two hypotheses: (1) nanoscale strains were lower in hip fracture patients versus controls, and (2) nanoscale mineral and fibril strains were inversely correlated with aging and fracture. A cross-sectional sample of trabecular bone sections was prepared from the proximal femora of two human donor groups (aged 44-94 years): an aging non-fracture control group (<i>n</i> = 17) and a hip-fracture group (<i>n</i> = 20). Tissue, fibril, and mineral strain were measured simultaneously using synchrotron X-ray diffraction during tensile load to failure, then compared between groups using unpaired t-tests and correlated with age using Pearson's correlation. Controls exhibited significantly greater peak tissue, mineral, and fibril strains than the hip fracture (all <i>p</i> < 0.05). Age was associated with a decrease in peak tissue (<i>p</i> = 0.099) and mineral (<i>p</i> = 0.004) strain, but not fibril strain (<i>p</i> = 0.260). Overall, hip fracture and aging were associated with changes in the nanoscale strain that are reflected at the tissue level. Data must be interpreted within the limitations of the observational cross-sectional study design, so we propose two new hypotheses on the importance of nanomechanics. (1) Hip fracture risk is increased by low tissue strain, which can be caused by low collagen or mineral strain. (2) Age-related loss of tissue strain is dependent on the loss of mineral but not fibril strain. Novel insights into bone nano- and tissue-level mechanics could provide a platform for the development of bone health diagnostics and interventions based on failure mechanisms from the nanoscale up.
Differentially Flat Designs of Mobile Vehicles With Under-Actuated Manipulator Arms (2007)

Differential flatness has been investigated in the context of mobile vehicles for planning and control of their motions. In these models, the wheels are considered to be non-slipping, i.e., the system dynamics is subject to non-holonomic constraints. If a manipulator arm is mounted on such a mobile vehicle, the dynamics becomes highly nonlinear due to the nonlinear coupling between the motions of the mobile vehicle and the manipulator arm. A challenging question is how to perform point-to-point motions of such a system in the state space of the mobile manipulator. If some of the actuators are absent in the mechanical arm, the mobile manipulator becomes under-actuated and consequently even harder to plan and control. This paper presents a methodology for design of mobile vehicles, mounted with under-actuated manipulators operating in a horizontal plane, such that the combined system is differentially flat. In this paper, we show that by appropriate inertia distribution of the links and addition of torsion springs at the joints, a range of under-actuated designs are possible where the underactuated mobile manipulator system is differentially flat. The differential flatness property allows to efficiently solve the problem of trajectory planning and feedback controller design for point to point motions of the system. The proposed method is illustrated by the example of a mobile vehicle with under-actuated three-link manipulator.
Variable-Stiffness–Mode Dielectric Elastomer Devices (2008)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Therapeutic applications of betulinic acid nanoformulations (2018)

Betulinic acid (BA), a naturally occurring plant-derived pentacyclic triterpenoid, has gained attention in recent years owing to its broad-spectrum biological and medicinal properties. Despite the pharmacological activity of BA, it has been associated with some drawbacks, such as poor aqueous solubility and short half-life in vivo, which limit therapeutic application. To solve these problems, much work in recent years has focused on enhancing BA's aqueous solubility, half-life, and efficacy by using nanoscale drug delivery systems. Several different kinds of nanoscale delivery systems-including polymeric nanoparticles, magnetic nanoparticles, liposomes, polymeric conjugates, nanoemulsions, cyclodextrin complexes, and carbon nanotubes-have been developed for the delivery of BA. Here, we focus on the recent developments of novel nanoformulations used to deliver BA in order to improve its efficacy.
High-Speed, Multi-Level Operation of All-Silicon Segmented Modulator for Optical DAC Transmitter (2020)

We have been developed high-speed, multi-level all-silicon segmented modulator for optical DAC transmitter. The broadband EO response of 42.6~43.9 GHz was obtained by passive RC equalizer using compact MIM capacitor. We experimentally demonstrated 70-Gbaud PAM4 operation by using segmented modulator.
InGaN/GaN laser diodes on semipolar (10$\bar 1$$\bar 1$) bulk GaN substrates (2008)

Abstract The first semipolar nitride laser diodes (LDs) have been realized on low extended defect density semipolar (10 $\bar 1$ $\bar 1$ ) GaN bulk substrates. The LDs were grown by conventional metal organic chemical vapor deposition (MOCVD). Broad area lasers with uncoated etched facets were fabricated and tested under pulsed conditions. Lasing was observed at a duty cycle of 0.025% with the threshold current density ( J th ) being 24.5 kA/cm 2 for a 5 µm × 800 µm device. An output power of 65 mW was measured from a single facet of the device at a drive current of 1.5 A, with the calculated differential quantum efficiency ( η diff ) being 8%. Stimulated emission was observed at 405.9 nm with a narrow full width half maximum (FWHM) of less than 0.3 nm. The lowest measured J th was 16.5 kA/cm 2 for a 10 µm × 800 µm device. (© 2008 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography (2016)

Minimally-invasive microsurgery has resulted in improved outcomes for patients. However, operating through a microscope limits depth perception and fixes the visual perspective, which result in a steep learning curve to achieve microsurgical proficiency. We introduce a surgical imaging system employing four-dimensional (live volumetric imaging through time) microscope-integrated optical coherence tomography (4D MIOCT) capable of imaging at up to 10 volumes per second to visualize human microsurgery. A custom stereoscopic heads-up display provides real-time interactive volumetric feedback to the surgeon. We report that 4D MIOCT enhanced suturing accuracy and control of instrument positioning in mock surgical trials involving 17 ophthalmic surgeons. Additionally, 4D MIOCT imaging was performed in 48 human eye surgeries and was demonstrated to successfully visualize the pathology of interest in concordance with preoperative diagnosis in 93% of retinal surgeries and the surgical site of interest in 100% of anterior segment surgeries. In vivo 4D MIOCT imaging revealed sub-surface pathologic structures and instrument-induced lesions that were invisible through the operating microscope during standard surgical maneuvers. In select cases, 4D MIOCT guidance was necessary to resolve such lesions and prevent post-operative complications. Our novel surgical visualization platform achieves surgeon-interactive 4D visualization of live surgery which could expand the surgeon's capabilities.
Supplemental figures 1-2 from Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth (2023)

&lt;p&gt;Supplemental figure 1. Lack of toxicity of KPT-9274 at 24 hours; Supplemental figure 2. Cell cycle analysis.&lt;/p&gt;
Surface modification of SiO2 nanoparticles for bacterial decontaminations of blood products (2022)

Bacterial infections can be caused by contamination of labile blood products with specific bacteria, such as Staphylococcus aureus and Staphylococcus epidermidis. Hospital equipment, bio-protective equipment, delivery systems, and medical devices can be easily contaminated by microorganisms. Multidrug-resistant bacteria can survive on various organic or inorganic polymeric materials for more than 90 days. Inhibiting the growth and eradicating these microorganisms is vital in blood transfusion processes. Blood bags and other related medical devices can be improved by the incorporation of organic or inorganic nanomaterials, particularly silicon dioxide (SiO2) nanoparticles. The addition of solid organic or inorganic nanoparticles to synthetic polymers or biopolymers can provide new properties in addition to antimicrobial activity. Among these NPs, formulations composed of SiO2 nanoparticles and polymers have been shown to improve the mechanical and antimicrobial properties of catheters, prosthetic inserts, blood bags, and other medical devices SiO2 nanoparticles possess several advantages, including large-scale synthetic availability, simple one-pot synthesis methods, porous structure for loading antibacterial agents, good biocompatibility, and thermal stability. Plasticized polyvinyl chloride is the main polymer, which has been functionalized by these nanoparticles. In this review, we discuss the recent advances and challenges regarding the functionalization of polyvinyl chloride by SiO2 nanoparticles to hinder bacterial contaminations in blood products.
Palladacycles as Structurally Defined Catalysts for the Heck Olefination of Chloro‐ and Bromoarenes (1995)

The catalytic CC coupling of chloroarenes by both the Heck and the Suzuki reactions has been achieved for the first time with new palladacycles of type 1, in which R can be, for instance, o-tolyl or mesityl. They are an order of magnitude more active than conventional catalysts and, moreover, thermally considerably more robust. But above all, the cleavage of the PC bond and the deposition of palladium is not observed. Analogous reactions with bromoarenes can also be catalyzed to advantage with 1. The Heck reaction of haloarenes with vinyl derivatives (e.g., n-butyl acryiate) gives (E)-styrene derivatives in one step. In the Suzuki reaction the haloarenes are converted into biphenyl derivatives with phenylbornic acid, also in one step.
Performance of All Solid Li-Air Battery (2019)

The Li–Air battery converts the electrochemical reactions of lithium and O 2 into electrical energy and has been receiving attention as the next generation battery because of its high theoretical specific energy of 3400 Wh kg -1 . The high specific energy of the Li–Air battery can be attributed to the reaction in the cathode where only Li and O 2 are needed, and it is an order of magnitude higher than that of the future generation Li ion battery that is predicted to reach at most 400 Wh kg -1 . In the cathode, the carbon particles are used to provide electron conductivity as well as the surface area for the reactions, and the electrolytes are necessary to transport Li + ions between the anode and cathode [1]. The pore distribution of the cathode is reported to influence the capacity [2], and the lifetime of the battery is reported to be limited by the stability of electrolyte [3]. To ensure higher stability against the oxidative conditions, the ionic liquid-based electrolytes are often used [4]. However, even the ionic liquid is known to decompose at the oxidative environment of the Li-Air battery operation conditions. To increase the cycle lifetime of the Li-Air battery, more stable form of electrolyte in cathode is desired. By constructing an all solid Li-Air battery which consists of Li metal, solid electrolyte, and oxide cathode, the source of cathode degradation can be greatly reduced by eliminating the liquid electrolyte and carbon in the cathode. The oxide material which showed both electronic and ionic conductivity in the order of 10 -4 S/cm was used as the cathode. The cathode material was ball milled to obtain sub-micron sized particles and the surface area in the order of 10 m 2 /g. The cathode was coated to obtain a 10 μm cathode layer, and the layer was sintered onto a LATP (Lithium aluminum titanium phosphate) electrolyte layer. The Li metal was then attached to the cathode/electrolyte to form an all solid Li-Air battery. To operate the Li-Air battery, the Li metal was isolated from the O 2 environment to which the cathode was exposed. The performance of the battery was evaluated in a O 2 filled chamber which had the relative humidity up to 100%. The discharge and charge curves were analyzed to evaluate the feasibility and the cycle lifetime of the all solid Li-Air battery. The composition of the discharge product and the possible reaction mechanism will be presented. The strategy to increase the specific energy and cycle lifetime of the battery will be also discussed. [1] D. Aurbach, B. D. McCloskey, L. F. Nazar and P. G. Bruce, Nat . Energy , 2016, 1 , 1–11. [2] N. Ding, S. W. Chien, T. S. A. Hor, R. Lum, Y. Zong and Z. Liu, J. Mater. Chem. A , 2014, 2 , 12433–12441. [3] S. A. Freunberger, Y. Chen, Z. Peng, J. M. Griffin, L. J. Hardwick, F. Barde, P. Novak and P. G. Bruce, J. Am. Chem. Soc., 2011, 133 , 8040–8047. [4] N. Mozhzhukhina, A. Y. Tesio, L. P. Mendez De Leo and E. J. Calvo, J. Electrochem. Soc., 2017, 164 , A518–523.
Straightforward synthesis of model polystyrene-block-poly(vinyl alcohol) diblock polymers (2018)

Well-defined polystyrene-<italic>block</italic>-poly(vinyl alcohol) (PS-<italic>b</italic>-PVA) polymers were synthesized<italic>via</italic>RDRP protocols. The morphology of the block polymers was investigated by GISAXS and AFM.
Dacrymenone and VM 3298-2 - New Antibiotics with Antibacterial and Antifungal Activity (2003)

Two new antibiotic metabolites, dacrymenone (1) and VM 3298-2 (2), were isolated from fermentations of a Dacrymyces sp., and their structures were determined by spectroscopic techniques. Dacrymenone (1) is a new eremophilane sesquiterpenoid while VM 3298-2 (2) is a bis-enol ether between methyl pyruvate and 4,6-dihydroxycyclohexan-1,3-dione. Dacrymenone (1) shows weak antibacterial and antifungal activity while VM 3298-2 (2) exhibits cytotoxic and antifungal activities.
Modeling Strategy for Networks with Both Stepwise and Chainwise Mechanisms: Amine-Epoxy Chemistry with Etherification (1989)

Abstract : A comparison between the entirely statistical and the combined kinetic and statistical models for amine-epoxy networks, both studied previously in the literature, is made. The chemistry studied involves the generation of a secondary site, which reacts in the network through chainwise addition, rather than the stepwise addition mode of the primary reaction. It is shown that the combined model (Bokare and Gandhi, 1980) is exact and the random model (Bidstrup, 1986; Riccardi and Williams, 1986; and Tsou and Peppas, 1988) is approximate. The assumptions underlying the two models are delineated. It is shown that under certain circumstances the predictions of the two models can differ by several hundred percent. Further, the combined model is extended to predict the postgel properties of the network. Keywords: Crosslinking (Chemistry): Ethers.
A direct-conversion transmitter for small-cell cellular base stations with integrated digital predistortion in 65nm CMOS (2016)

Network densification and FD MIMO in cellular networks require higher levels of base station integration while still meeting stringent performance requirements. We present a monolithic transmitter with integrated digital predistortion and calibration which allows RF agile, multi-carrier operation and enables efficient small cell and FD MIMO systems to be realized below 24dBm/antenna.
Correction to Conformational Properties of Nine Purified Cystathionine β-Synthase Mutants (2012)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Conformational Properties of Nine Purified Cystathionine β-Synthase MutantsAleš Hnı́zda, Tomas Majtan, Lu Liu, Angel L. Pey, John F. Carpenter, Milan Kodı́ček, Viktor Kožich, and Jan P. Kraus*Cite this: Biochemistry 2012, 51, 27, 5540Publication Date (Web):June 27, 2012Publication History Received18 June 2012Published online27 June 2012Published inissue 10 July 2012https://pubs.acs.org/doi/10.1021/bi300812fhttps://doi.org/10.1021/bi300812fcorrectionACS PublicationsCopyright © 2012 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views362Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (136 KB) Get e-Alertsclose Get e-Alerts
Computational Modeling and Imaging of the Intracellular Oxygen Gradient (2022)

Computational modeling can provide a mechanistic and quantitative framework for describing intracellular spatial heterogeneity of solutes such as oxygen partial pressure (pO<sub>2</sub>). This study develops and evaluates a finite-element model of oxygen-consuming mitochondrial bioenergetics using the COMSOL Multiphysics program. The model derives steady-state oxygen (O<sub>2</sub>) distributions from Fickian diffusion and Michaelis-Menten consumption kinetics in the mitochondria and cytoplasm. Intrinsic model parameters such as diffusivity and maximum consumption rate were estimated from previously published values for isolated and intact mitochondria. The model was compared with experimental data collected for the intracellular and mitochondrial pO<sub>2</sub> levels in human cervical cancer cells (HeLa) in different respiratory states and under different levels of imposed pO<sub>2</sub>. Experimental pO<sub>2</sub> gradients were measured using lifetime imaging of a Förster resonance energy transfer (FRET)-based O<sub>2</sub> sensor, Myoglobin-mCherry, which offers in situ real-time and noninvasive measurements of subcellular pO<sub>2</sub> in living cells. On the basis of these results, the model qualitatively predicted (1) the integrated experimental data from mitochondria under diverse experimental conditions, and (2) the impact of changes in one or more mitochondrial processes on overall bioenergetics.
Src Homology Domains of Phospholipase C γ1 Inhibit Nerve Growth Factor‐Induced Differentiation of PC12 Cells (1998)

Phospholipase C gamma1 (PLC-gamma1) is phosphorylated on treatment of cells with nerve growth factor (NGF). To assess the role of PLC-gamma1 in mediating the neuronal differentiation induced by NGF treatment, we established PC12 cells that overexpress whole PLC-gamma (PLC-gamma1PC12), the SH2-SH2-SH3 domain (PLC-gamma1SH223PC12), SH2-SH2-deleted mutants (PLC-gamma1deltaSH22PC12), and SH3-deleted mutants (PLC-gamma1deltaSH3PC12). Overexpressed whole PLC-gamma1 or the SH2-SH2-SH3 domain of PLC-gamma1 stimulated cell growth and inhibited NGF-induced neurite outgrowth of PC12 cells. However, cells expressing PLC-gamma1 lacking the SH2-SH2 domain or the SH3 domain had no effect on NGF-induced neuronal differentiation. Overexpression of intact PLC-gamma1 resulted in a threefold increase in total inositol phosphate accumulation on treatment with NGF. However, overexpression of the SH2-SH2-SH3 domain of PLC-gamma1 did not alter total inositol phosphate accumulation. To investigate whether the SH2-SH2-SH3 domain of PLC-gamma1 can mediate the NGF-induced signal, tyrosine phosphorylation of the SH2-SH2-SH3 domain of PLC-gamma1 on NGF treatment was examined. The SH2-SH2-SH3 domain of PLC-gamma1 as well as intact PLC-gamma1 could be tyrosine-phosphorylated on NGF treatment. These results indicate that the overexpressed SH2-SH2-SH3 domain of PLC-gamma1 can block the differentiation of PC12 cells induced by NGF and that the inhibition appears not to be related to the lipase activity of PLC-gamma1 but to the SH2-SH2-SH3 domain of PLC-gamma1.
Tunneling Magnetoresistance and Spin-Dependent Diode Performance in Fully Epitaxial Magnetic Tunnel Junctions With a Rocksalt ZnO/MgO Bilayer Tunnel Barrier (2019)

Metal/insulator/metal (MIM) tunnel diodes are promising for high-frequency rectifier systems, such as for energy harvesting in the infrared-to-terahertz range, where typical semiconductor devices cannot operate. For practical applications, though, better rectification is needed. The authors fabricate fully epitaxial Fe/ZnO/MgO/Fe tunnel junctions exhibiting 96% magnetoresistance at room temperature, as well as greatly enhanced rectification performance, due to magnon excitations at the Fe/barrier interfaces. This is an exciting result for energy harvesting at longer wavelengths.