gebhart/patrepeval huggingface dataset:
Prediction of tensile strength in fused deposition modeling process using artificial neural network technique (2020)

Fused deposition modeling (FDM) has many different levels of parameters hence prediction method is required for FDM users. The main aim of this paper is to predict the mechanical strength of the components before fabrication of FDM process. In this paper, the most influenced FDM process parameters of Layer thickness, Infill density, print speed, temperature and build orientation were considered for prediction of tensile strength of the fabricated part. The tensile test specimen (ASTM-D638) was fabricated by FDM process with PLA (Polylactic Acid) material, based on the central composite design. The actual tensile strength values were obtained by conducting a test on Universal Testing Machine (UTM) for the PLA material. The results data were used to develop the mathematical models for the prediction of tensile strength of fabricated part from response surface methodology (RSM) and analysis of variance (ANOVA). Similarly, ANN tool was used to predict the tensile strength of the specimen with the aid of 33 experiments and result data. The predicted values from the results of RSM, ANN, ANOVA were compared with the actual tensile strength. The ANN technique gives the minimum value of percentage deviation in Error (1-2%).
Altered Fate of Subventricular Zone Progenitor Cells and Reduced Neurogenesis following Neonatal Stroke (2010)

Neurogenesis originating from cells of the lateral ventricle, including SVZ type B cells, is significantly reduced following neonatal stroke. Furthermore, neonatal stroke disrupts gliogenesis in the striatum, decreasing overall numbers of new glia and shifting the population towards astrocytes.
Implementing a comprehensive translational oncology platform: from molecular testing to actionability (2018)

We report the feasibility of real-time tissue acquisition and analysis to support a successful translational oncology platform. The workflow will provide the foundation to improve access and accrual to biomarker driven precision oncology trials.
Mini-review of hair cortisol concentration for evaluation of Cushing syndrome (2018)

Recent evidence suggests increased sensitivity and specificity of hair cortisol in detecting Cushing syndrome. Future guidelines should consider this test as a routine part of the repertoire of screening tests for Cushing syndrome. Possible confounders to explain discrepant results in the literature will be discussed.
Overexpression of the Sm-like proto-oncogene in primary and metastatic pancreatic endocrine tumors. (2002)

Our results indicate that the cancer associated Sm-like mRNA gene may also play a role in the tumorigenesis of pancreatic endocrine tumors.
Efficient Multikilogram Synthesis of 5-Bromo-2-cyclopropyl-1-methyl-1H-imidazole (2007)

Herein we describe the optimization and application of a copper(I) chloride-mediated protocol for the multikilogram synthesis of 5-bromo-2-cyclopropyl-1-methyl-1H-imidazole hydrochloride (1), a key building block used in the preparation of several biologically active small molecules.
Uniaxial crystal interferometer: principles and forecasted applications to imaging astrometry (2005)

We propose a new approach to imaging astrometry, the uniaxial crystal interferometer (UCI). It uses the extremely sensitive dependence of the polarization phase change on the incident angle in uniaxial crystals. This is further combined with very sensitive polarization measurements. The polarization-coding is used for a fine-scale angle determination, and is simultaneously combined with a crude measurement through a standard telescope. Further, achromatic anamorphic prisms will amplify five to tenfold the resolution which is estimated to reach the scale ratio of large interferometers. Because the fine angular information is superimposed on the light at an early stage the optical system tolerances are relieved to the level of a standard low-weight optical imaging system. We also suggest solutions to make the system achromatic. Overall the system may cover sky segments of the order of fractions of a degree square and reach a resolution of tens of microas, even for faint stars.
The Gaussian Mixture Cardinalized PHD tracker on MSTWG and SEABAR’07 datasets (2008)

In this paper, we apply a Gaussian Mixture cardinalized PHD tracker to several real and simulated datasets from the MSTWG (Multistatic Tracking Working Group) library from NURC, TNO and ARL:UT. We also report our analysis on the SEABARpsila07 sea experiment.
Low-complexity distributed set-theoretic decoders for analog fountain codes (2018)

Analog fountain codes (AFCs) have been recently proposed as a capacity-approaching coding scheme for Gaussian channels. In AFCs, coded symbols are real valued, and the number of generated codes can grow unboundedly. In this work, we exploit these characteristics of AFCs to pose the decoding process as an adaptive filtering problem. This formulation opens up the possibility of deriving a large family of online decoding algorithms that process coded symbols as they arrive, in a truly online fashion. In particular, we present two algorithms based on the adaptive projected subgradient method, and we further improve the performance of these algorithms by using heuristics inspired by recent results on superiorization. We also show that the proposed techniques can be trivially extended to distributed settings where receivers can exchange information locally. Simulations show that the proposed techniques can outperform state-of-the-art batch methods in some scenarios.
Structure and mechanical properties of ZDTP films in oil (1998)

ISBN 0-444-50267-X
The challenge of magnetic vagal nerve stimulation for myocardial infarction -preliminary clinical trial (2017)

Numerous studies have shown in animal models that vagal nerve stimulation (VNS) strikingly reduces infarct size of acute myocardial infarction (AMI) and prevents heart failure. However, the lack of techniques to noninvasively stimulate the vagal nerve hinders VNS from clinical applications. Transcranial magnetic stimulation is noninvasive and capable of stimulating central neurons in patients. In this study, we examined whether the magnetic stimulation could noninvasively activate the cervical vagal nerve in healthy human. Sixteen healthy males and 4 females were enrolled in this study. We used Magstim Rapid2 with a 70-mm double coil in the right neck. We randomly assigned the subjects to 5 Hz or 20 Hz stimulation. We defined the maximum intensity of stimulation (MAX) which is the intensity just below the threshold of adverse effects. We defined HALF as a half of MAX. Protocols comprised 2 sets of MAX and 2 sets of HALF. Each stimulation continued for 3 minutes. We monitored heart rate (HR) and assessed the bradycardic response as an index of successful VNS. Nineteen subjects completed all protocols. They had no problematic adverse events during and/or after magnetic VNS. The magnetic VNS induced transient bradycardic responses in some subjects, whereas failed to induce sustained bradycardia in pooled data in any settings. Arterial pressure did not change either. Successful magnetic stimulation requires technical improvements including narrowing the magnetic focus and optimization of stimulation site. These improvements may enable us to apply magnetic VNS in the management of AMI.
Cross-Layer Resilience (2019)

Resilience to errors in the underlying hardware is a key design objective for a large class of computing systems, from embedded systems all the way to the cloud. Sources of hardware errors include radiation, circuit aging, variability induced by manufacturing and operating conditions, manufacturing test escapes, and early-life failures. Many publications have suggested that cross-layer resilience, where multiple error resilience techniques from different layers of the system stack cooperate to achieve cost-effective resilience, is essential for designing cost-effective resilient digital systems. This paper presents a comprehensive overview of cross-layer resilience by addressing fundamental cross-layer resilience questions, by summarizing insights derived from recent advances in cross-layer resilience research, and by discussing future cross-layer resilience challenges.
Two-point distribution function for a dispersion of impenetrable spheres in a matrix (1986)

Results are reported for the two-point distribution function G2(r) of two-phase random media composed of equisized impenetrable spheres in a matrix. G2 arises in various expressions for transport and mechanical properties of heterogeneous materials.
Traffic pattern based Virtual Network Embedding (2013)

Virtual Network Embedding (VNE) algorithms are used to find the best embedding of multiple Virtual Networks (VNs) with respect to a performance metric such as network utiliza-tion. However, most algorithms assume that the demands of the VNs are static over time. We focus on VNE algorithms for VNs whose demands are changing according to traffic patterns of their provided services. In order to always guar-antee high performance and network resource efficiency, the embedding of the VNs has to change, i.e., the VNs have to be re-embedded. By considering traffic patterns of different services, we propose an algorithm that looks ahead and min-imize the impact of reconfigurations that are the result of a re-embedding. First simulation results show the potential of VNE algorithms that consider the behavior of evolving service demands.
SA93. Deletion of CNTNAP2 and White Matter Changes in Schizophrenia (2017)

Background: Schizophrenia (SZ) is a severe mental disorder with heritability estimated at ~80%. Genetic variants in contactin-associated protein-like 2 (CNTNAP2) have been reported in SZ. This gene is critically involved in normal neuronal synchronization and myelin production. Deletions in this gene would therefore be expected to impact white matter (WM) integrity. Compromised WM integrity has been implicated in SZ and may also be a heritable biomarker. In order to help characterize the genetic components of WM changes in SZ, we examined 2 carriers of a large heterozygous deletion in CNTNAP2 with discordant clinical phenotypes. Methods: A 59-year-old female proband who met DSM-IV criteria for a diagnosis of schizoaffective disorder (depressed subtype), her clinically unaffected 90-year-old father, and 4 unrelated nonpsychiatric controls completed a diffusion kurtosis imaging protocol on a Siemens 3T system. Human-induced pluripotent stem cell (hiPSC) lines from skin biopsies of both carriers were generated and differentiated in vitro to oligodendrocytes. Results: The fractional anisotropy (FA) and radial kurtosis (RK) were reduced, and the radial diffusivity (RD) was increased in the corona radiata and the genu of the corpus callosum (CC) in the proband compared with the father and controls. The clinically unaffected father closely resembled the controls in the genu of CC but differed from them in the uncinate fasciculus and internal capsule. In the whole-brain WM analysis, the FA and RK were reduced, and the RD was increased, in both the proband and the father compared with the controls, more substantially in the proband than in the father. Preliminary results from the in vitro differentiation suggest defective differentiation of patient-derived hiPSCs to oligodendrocyte precursor cells in the proband only. Conclusion: These preliminary data suggest that WM integrity is compromised in both carriers, possibly due to a demyelinating process that may be associated with this specific mutation. More severe and widespread demyelination is present in the clinically affected proband than in the unaffected carrier father, suggesting that additional WM changes may be associated with SZ, possibly independent of this mutation. These findings complement the molecular and cellular phenotypes of the hiPSC neural cells derived from these carriers and support the role of brain imaging in helping to elucidate objectively measurable neuroanatomic phenotypic consequences of genetic variant susceptibility. This is one of the first studies to combine neuroimaging and hiPSC-based observations in carriers of the same mutation with discordant phenotypes, demonstrating the utility of both approaches in understanding pleiotropic clinical effects.
HSP60 as a Target of Anti-Ergotypic Regulatory T Cells (2008)

The 60 kDa heat shock protein (HSP60) has been reported to influence T-cell responses in two ways: as a ligand of toll-like receptor 2 signalling and as an antigen. Here we describe a new mechanism of T-cell immuno-regulation focused on HSP60: HSP60 is up-regulated and presented by activated T cells (HSP60 is an ergotope) to regulatory (anti-ergotypic) T cells. Presentation of HSP60 by activated T cells was found to be MHC-restricted and dependent on accessory molecules - CD28, CD80 and CD86. Anti-ergotypic T cells responded to T-cell HSP60 by proliferation and secreted IFNgamma and TGFbeta1. In vitro, the anti-ergotypic T cells inhibited IFNgamma production by their activated T-cell targets. In vivo, adoptive transfer of an anti-ergotypic HSP60-specific T-cell line led to decreased secretion of IFNgamma by arthritogenic T cells and ameliorated adjuvant arthritis (AA). Thus, the presentation of HSP60 by activated T cells turns them into targets for anti-ergotypic regulatory T cells specific for HSP60. However, the direct interaction between the anti-ergotypic T regulators (anti-HSP60) and the activated T cells also down-regulated the regulators. Thus, by functioning as an ergotope, HSP60 can control both the effector T cells and the regulatory HSP60-specific T cells that control them.
IBM POWER9 circuit design and energy optimization for 14-nm technology (2018)

Modern multicore microprocessors require attentive development to energy requirements when maximizing power-performance efficiency and ensuring reliable plus scalable functionality. IBM POWER9 relies on extensive modeling to identify representative workloads used when analyzing thermal design power and regulator design power against product requirements. Compounding benefits of circuit optimizations applied to the diverse subcomponents of the chip results in lower power cores, caches, and memory/IO interconnect. Specific dc- and ac-current analyses ensure proper definition of chip specifications for system voltage and current delivery. Finally, a systematic exploration of microbenchmarks on intermediate and final POWER9 hardware provides insight into processor core requirements while validating model accuracy.
<title>Augmented haptics of manipulator kinematic condition</title> (1999)

This paper describes a study of whether haptic feedback can be used to represent information that is normally difficult to obtain via visual feedback in telerobotic system. Problems of manipulator kinematic condition such as singularity and joint limit have been well known for a long time. Kinematic condition of the manipulator is difficult to be recognized visually. Poor kinematic condition often causes trajectory error or other undesirable effects in the system. This problem is quite significant in telerobotics since a fully pre-planned path that completely excludes poor kinematic condition is usually not available.
A comparison of primary and revision total knee arthroplasty using the kinematic stabilizer prosthesis. (1988)

The first 121 arthroplasties (in 105 patients) in which the cemented kinematic-stabilizer total knee prosthesis was used for primary arthroplasty or surgical revision at the Mayo Clinic were reviewed. Sixty-six patients (seventy-nine arthroplasties) were followed for a mean of thirty-seven months. There were fifty-three revision and twenty-six primary arthroplasties. The average range of motion in both groups increased from 95 to 101 degrees. Although none of these patients could ascend stairs without support before the operation, thirty-two (51 per cent) could do so at the time of the final follow-up. The incidence of moderate or severe pain was reduced from 86 to 6 per cent. Moderate or severe ligamentous instability had been present in thirty-three knees (42 per cent) preoperatively, but only five knees had significant medial, lateral, anterior, or posterior instability at final follow-up. The Hospital for Special Surgery knee score increased from an average of 56 points to 83 points in all of the knees. At follow-up, the patients who had had primary arthroplasty had 92 per cent good or excellent results and the patients who had had surgical revision had 81 per cent good or excellent results (p less than 0.05). There was no significant difference in the results between the patients who had osteoarthritis and those who had rheumatoid arthritis. Over-all, 85 per cent of the results were good or excellent at final follow-up. Tibial radiolucent lines of one to two millimeters were observed in 29 per cent of the knees at follow-up.(ABSTRACT TRUNCATED AT 250 WORDS)
Wall Sheath and Electron Mobility Modeling in Hybrid-PIC Hall Thruster Simulations (2007)

Progress on the development of physics-based modeling tools aimed at predicting the service life of Hall thrusters is discussed. Modifications of the wall sheath and electron mobility models in the hybrid fluid/particle-in-cell computer code HPHall-2 are made and the effects of these changes on the plasma parameters and thruster performance are assessed. The wall sheath model of Hobbs and Wesson [Plasma Physics, 9, 85-87 (1967)] has been adopted, resulting in modifications to the predicted sheath potentials that are relevant to the modeling of high specific impulse Hall thrusters. Experiments with a widely used mixed-mobility model of the cross-field electron transport is presented that enables the simultaneous prediction of thrust and discharge current in agreement with experimental data. Taken together, these code modifications have improved the predictive capability of HPHALL-2 to serve as an input for studies of Hall thruster erosion.
Compositions for chromosome-specific staining (2023)

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods are provided to disable the hybridization capacity of shared, high copy repetitive sequences and/or remove such sequences to provide for useful contrast. Still further methods are provided to produce chromosome-specific staining reagents which are made specific to the targeted chromosomal material, which can be one or more whole chromosomes, one or more regions on one or more chromosomes, subsets of chromosomes and/or the entire genome. Probes and test kits are provided for use in tumor cytogenetics, in the detection of disease related loci, in analysis of structural abnormalities, such as translocations, and for biological dosimetry. Further, methods and prenatal test kits are provided to stain targeted chromosomal material of fetal cells, including fetal cells obtained from maternal blood. Still further, the invention provides for automated means to detect and analyse chromosomal abnormalities.
Significance of Average Domain Purity and Mixed Domains on the Photovoltaic Performance of High‐Efficiency Solution‐Processed Small‐Molecule BHJ Solar Cells (2015)

Whereas the role of molecularly mixed domains in organic photovoltaic devices for charge generation is extensively discussed in the literature, the impact on charge recombination and thus fill factor is largely unexplored. Here, a combination of soft X‐ray techniques enables the quantification of phases at multiple length scales to reveal their role regarding charge recombination in a highly efficient solution processed small molecule system 7,7′‐(4,4‐bis(2‐ethylhexyl)‐4H‐silolo[3,2‐b:4,5‐b′]dithiophene‐2,6‐diyl)bis(6‐fluoro‐4‐(5′‐hexyl‐[2,2′‐bithiophen]‐5‐yl)benzo[c][1,2,5]thiadiazole) (p‐DTS(FBTTh 2 ) 2 ) . A quantitative (linear) relationship between the average composition variations and the device fill‐factor is observed. The results establish the complex interrelationship between average phase purity, domain size, and structural order and highlight the requirement of achieving sufficient phase purities to diminish bimolecular and geminate recombination in solution processed small molecule solar cells.
1092. Adenovirus-Based Vaccine Prevents Pneumonia in Ferrets Challenged with the SARS Coronavirus (2005)

Top of pageAbstract
The human severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiologic agent responsible for the spread of the acute respiratory syndrome in Asia and Canada that claimed several human lives in 2003. A ferret model of SARS-CoV infection was used to evaluate the efficacy of an adenovirus-based vaccine. Ferrets infected with a clinical isolate of SARS-CoV via intranasal inhalation developed a syndrome similar to that observed in humans that consisted of fever and clinical signs of toxicity. Virus replicated in lung and was recovered in nasal washes. Patchy but widely disseminated bronchopneumonia developed characterized by infiltration of neutrophils and monocytes. Animals were vaccinated with recombinant adenoviruses expressing the Spike protein of SARS-CoV prior to challenge with SARS-CoV. The most impressive therapeutic results were obtained when the animals were primed with a human adenovirus expressing Spike and boosted with a serologically distinct adenovirus from chimpanzee also expressing the Spike antigen. Following challenge with SARS-CoV the acute fever was lessened and clinical sequalae were diminished. Viral loads in lung and nasal washes were down 6 logs as compared to animals vaccinated with a control vector. There was no evidence of gross lung pathology at necropsy and histological findings were limited to mild focal inflammation in alveolar septa and around some small airways. The same prime boost strategy was also effective in rhesus macaques and resulted in SARS-CoV neutralizing antibody titers of up to 1/2560 and |[gamma]|-INF positive T cells reaching 12,000 SFC per million PBMCs as assessed by ELISPOT. These data indicate that a heterologous adenovirus-based prime boost vaccine strategy could stimulate a strong immunity that may be needed for complete protection against SARS-CoV infection.
Fhit proteins can also recognize substrates other than dinucleoside polyphosphates (2008)

We show here that Fhit proteins, in addition to their function as dinucleoside triphosphate hydrolases, act similarly to adenylylsulfatases and nucleoside phosphoramidases, liberating nucleoside 5'-monophosphates from such natural metabolites as adenosine 5'-phosphosulfate and adenosine 5'-phosphoramidate. Moreover, Fhits recognize synthetic nucleotides, such as adenosine 5'-O-phosphorofluoridate and adenosine 5'-O-(gamma-fluorotriphosphate), and release AMP from them. With respect to the former, Fhits behave like a phosphodiesterase I concomitant with cleavage of the P-F bond. Some kinetic parameters and implications of the novel reactions catalyzed by the human and plant (Arabidopsis thaliana) Fhit proteins are presented.
Speech recognition in university classrooms (2002)

The LIBERATED LEARNING PROJECT (LLP) is an applied research project studying two core questions: 1) Can speech recognition (SR) technology successfully digitize lectures to display spoken words as text in university classrooms? 2) Can speech recognition technology be used successfully as an alternative to traditional classroom notetaking for persons with disabilities? This paper addresses these intriguing questions and explores the underlying complex relationship between speech recognition technology, university educational environments, and disability issues.