gebhart/patrepeval huggingface dataset:
A PARALLEL GENETIC ALGORITHM FOR HEAT CONDUCTION PROBLEMS (2005)

ABSTRACT Genetic algorithms are a global optimization method that is ideally suited for implementation on parallel computers. In this article, a genetic algorithm developed to solve problems in heat conduction is parallelized and run on a parallel computer (IBM SP2). The algorithm presented here contains a novel local search operator that greatly improves its accuracy. The algorithm itself and the parallelization strategy are discussed in the first part of the article, followed by a detailed discussion of the algorithm's results and its performance vis-à-vis its serial version. The authors wish to thank the UC Berkeley Block Grant program for facilitating the necessary computing resources for this project, as well as the staff at the San Diego Supercomputing Center for their valuable assistance during the course of this work.
Single Blastomeres within Human Preimplantation Embryos Express Different Amounts of Messenger Ribonucleic Acid for β-Actin and Interleukin-1 Receptor Type I1 (1998)

Gaining knowledge about the physiological timetable of gene expression during preimplantation embryo development is crucial, and a better understanding of cytokine and growth factor expression in early embryonic development could lead to improved in vitro culture conditions and enhance in vitro fertilization implantation rates. Our aim was to detect the patterns and levels of two messenger ribonucleic acids [mRNAs; beta-actin and interleukin-1 receptor type I (IL-1R tI)] in single human blastomeres by RT-nested PCR and to compare possible variations in the gene expression both between different embryos and in multiple blastomeres within the same embryo. Single blastomeres from nine human tripronucleic preimplantation embryos were examined by one round of RT and two rounds of nested competitive PCR. Beta-actin mRNA was detected in each blastomere, and IL-1R tI mRNA was found in 72% of the blastomeres examined. Beta-actin was expressed at a level of 511-12185 molecules of complementary DNA/blastomere, and IL-1R tI was expressed at a level of 2-290 molecules of complementary DNA/blastomere. Our results suggest that the mRNA pattern of an embryo cannot be reliably quantitated from the mRNA pattern of a single blastomere and therefore imply limitations for the use of this method for preimplantation diagnosis.
Comment on ‘‘Pair of local vibration mode absorption bands related to EL2 defects in semi-insulating GaAs’’ [Appl. Phys. Lett. 5 0, 1666 (1987)] (1988)

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Sensitization of enteric neurons to morphine byHIV‐1 Tat protein (2015)

Overall, these data suggest that the sensitivity of enteric neurons to morphine is enhanced in the presence of Tat. Opiates and HIV-1 may uniquely interact to exacerbate the deleterious effects of HIV-1-infection and opiate exposure on GI function.
Titration of Recombinant Aequorin with Calcium Chloride (1996)

The photoprotein aequorin emits light in the presence of a trace of Ca2+. The primary structure of the protein indicates the presence of three Ca2+-binding sites, whereas the luminometric titration of heterogeneous natural aequorin with Ca2+ has shown that the light emission takes place by the binding of two Ca2+ ions. In the case of recombinant aequorin, which is more suitable for quantitative studies, the titration with Ca2+ monitored by a Ca2+-sensitive electrode revealed that the photoprotein can bind more than two, most likely three, Ca2+ ions, and the luminometric titration conclusively showed that the luminescence is triggered by the first two Ca2+ ions bound. The affinity of recombinant aequorin for the first two Ca2+ ions, which are essential for light emission, was about 20 times stronger than that for the third Ca2+ ion, which is unrelated to light emission.
A 2D Semiconductor–Self‐Assembled Monolayer Photoswitchable Diode (2015)

A switchable diode in a 2D semiconductor-molecular junction heterostructure is reported. MoS2 is exfoliated on top of a monolayer of azobenzene-substituted thiols on gold. Photoisomerization of the azobenzenes results in switching between a rectifier with rectifying ratios of 10(4) and a conductive state, as revealed by conducting atomic force microscopy.
Inherited balanced translocation t(9;17)(q33.2;q25.3) concomitant with a 16p13.1 duplication in a patient with schizophrenia (2011)

We report two rare genetic aberrations in a schizophrenia patient that may act together to confer disease susceptibility. A previously unreported balanced t(9;17)(q33.2;q25.3) translocation was observed in two schizophrenia-affected members of a small family with diverse psychiatric disorders. The proband also carried a 1.5 Mbp microduplication at 16p13.1 that could not be investigated in other family members. The duplication has been reported to predispose to schizophrenia, autism and mental retardation, with incomplete penetrance and variable expressivity. The t(9;17) (q33.2;q25.3) translocation breakpoint occurs within the open reading frames of KIAA1618 on 17q25.3, and TTLL11 (tyrosine tubulin ligase like 11) on 9q33.2, causing no change in the expression level of KIAA1618 but leading to loss of expression of one TTLL11 allele. TTLL11 belongs to a family of enzymes catalyzing polyglutamylation, an unusual neuron-specific post-translational modification of microtubule proteins, which modulates microtubule development and dynamics. The 16p13.1 duplication resulted in increased expression of NDE1, encoding a DISC1 protein partner mediating DISC1 functions in microtubule dynamics. We hypothesize that concomitant TTLL11-NDE1 deregulation may increase mutation load, among others, also on the DISC1 pathway, which could contribute to disease pathogenesis through multiple effects on neuronal development, synaptic plasticity, and neurotransmission. Our data illustrate the difficulties in interpreting the contribution of multiple potentially pathogenic changes likely to emerge in future next-generation sequencing studies, where access to extended families will be increasingly important.
The dissolution behavior of tetrafluoroethylene-based fluoropolymers for 157-nm resist materials (2004)

Main-chain-fluorinated base-resins, using the copolymer of tetrafluoroethylene and functional (hexafluoroisopropanol (HFA) group) norbornene, were synthesized. Partial protection of its hydroxyl group as ethoxymethyl group was achieved by two methods, by copolymerization (Method A) or by polymer reaction (Method B). The partial protection by copolymerization was conducted by copolymerizing TFE with the mixture of protected and unprotected monomers (Method A, copolymerization). The partial protection was also carried out by reacting hydroxyl group of the polymer, which is composed of TFE and unprotected monomers with ethoxymethyl chloride in the presence of an amine (Method B). In the polymer reaction, only exo position of the norbornene unit was protected. Their fundamental properties, such as transparency at 157 nm and solubility in a standard alkaline developer, were characterized and studied. A high transparency, i.e., absorbance of less than 0.4 &mu;m<sup>-1</sup>, was achieved in both methods. However, the polymer prepared by the polymer reaction (Method B) was deprotected more quickly. And this polymer had a higher dissolution rate and development contrast than the polymer prepared by copolymerization (Method A). The Positive-working resists based on this fluororesins were developed and 55 nm dense lines could be delineated by the exposure at 157 nm wavelength with alternating phase shift mask on a 0.9 NA 157 nm exposure tool.
Narrowband jammer resistance for MIMO OFDM (2008)

Multi-input multi-output (MIMO) antenna systems provide the user with additional degrees of freedom over traditional single antenna (SISO) system to enable optimum transmission. This paper focuses on the use of multi-antenna techniques to compensate for in-band interference in scatter rich environments.We consider the effects of narrowband interference in a collection of typical channels with delay spreads and losses representative of both indoor and outdoor environments. We show the performance of a multi antenna technique that can be used to combat these types of interference. We present an analysis of the performance of this technique in channels with varying amounts of dispersion. Both simulation and experimental results will be discussed and presented. The experimental results are collected from testing performed on a highly versatile MIMO OFDM testbed developed at Silvus Technologies. The testbed uses a waveform similar to 802.11 n. The chosen method will show up to 30 dB rejection of the interfering signal, thereby allowing us to achieve roughly 50% of the unjammed throughput in the presence of strong jammer. We also show that this method is proven on real-time hardware, where we successfully received a 23 Mbps stream of data with a signal to interference ratio of -20 dB.
Neisseria gonorrhoeae Becomes Susceptible to Polymyxin B and Colistin in the Presence of PBT2 (2019)

<i>Neisseria gonorrhoeae</i> (<i>N. gonorrhoeae</i>) causes the sexually transmitted disease gonorrhea, which has a global incidence of 106 million cases per year. No vaccine is available to prevent the disease, and the emergence of multidrug resistant (MDR) strains makes <i>N. gonorrhoeae</i> an immediate public health threat. Here, we show that an ionophore, PBT2, can reverse the intrinsic resistance of <i>N. gonorrhoeae</i> to polymyxin B and colistin. These antibiotics administered in combination with PBT2 may be an effective path to treat MDR gonococcal infections.
Metallic carbon materials (2023)

Novel metallic forms of planar carbon are described, as well as methods of designing and making them. Nonhexagonal arrangements of carbon are introduced into a graphite carbon network essentially without destroying the planar structure. Specifically a form of carbon comprising primarily pentagons and heptagons, and having a large density of states at the Fermi level is described. Other arrangements of pentagons and heptagons that include some hexagons, and structures incorporating squares and octagons are additionally disclosed. Reducing the bond angle symmetry associated with a hexagonal arrangement of carbons increases the likelihood that the carbon material will have a metallic electron structure.
Synthesis and reactivity of halide, hydride, and alkyl derivatives of (pentamethylcyclopentadienyl)(bisphosphine)iron(II) (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and reactivity of halide, hydride, and alkyl derivatives of (pentamethylcyclopentadienyl)(bisphosphine)iron(II)Rocco A. Paciello, Juan M. Manriquez, and John E. BercawCite this: Organometallics 1990, 9, 1, 260–265Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/om00115a038https://doi.org/10.1021/om00115a038research-articleACS PublicationsRequest reuse permissionsArticle Views446Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficacy studies of an antibody‐drug conjugate PSMA‐ADC in patient‐derived prostate cancer xenografts (2014)

Our results show high efficacy of PSMA ADC in advanced prostate cancer but also considerable variability in effects despite PSMA expression. Further studies to identify tumor characteristics that are predictive of treatment response are ongoing.
Dynamic Adaptation of Temporal Event Correlation Rules (2005)

Temporal event correlation is essential to realizing self-managing distributed systems. Autonomic controllers often require that events be correlated across multiple components using rule patterns with timer-based transitions, e.g., to detect denial of service attacks and to warn of staging problems with business critical applications. This short paper discusses automatic adjustment of timer values for event correlation rules, in particular compensating for the variability of event propagation delays due to factors such as contention for network and server resources. We describe a corresponding Management Station architecture and present experimental studies on a testbed system that suggest that this approach can produce results at least as good as an optimal fixed setting of timer values.
Current status of insecticide resistance in Q biotype Bemisia tabaci populations from Crete (2008)

Bemisia tabaci resistance evolved differently in each of the three insecticides studied. Imidacloprid resistance seems less established and less persistent than alpha-cypermethrin resistance. The low resistance levels for pirimiphos-methyl suggest absence of cross-resistance with other organophosphates or carbamates used.
Etching of high aspect ratio structures in Si using SF6/O2 plasma (2004)

We have investigated etching of deep (∼10 μm) submicron diameter holes with high aspect ratios (&amp;gt;10) using plasmas maintained in mixtures of SF6 and O2 gases. The etching experiments were conducted in a low-pressure (5–80 mTorr), high-density, inductively coupled plasma etching reactor with a planar coil. We have studied the effects of pressure, rf-bias voltage, and SF6-to-O2 gas ratio on the etch rate, selectivity, and feature profile using Si wafers patterned with 0.35–0.5 μm diameter holes in a SiO2 mask. Visualization of the profiles with scanning electron microscopy is used in conjunction with plasma diagnostics such as optical emission and mass spectroscopies to understand the key factors that control the anisotropy, selectivity, and etch rate. The F-to-ion flux ratio and F-to-O flux ratio are found to be the important plasma parameters that determine the etch rate and anisotropy. Increasing the SF6-to-O2 ratio in the feed gas increases the F-to-O ratio in the plasma. At high SF6-to-O2 ratio, the mask undercut is severe because sidewall passivation by O atoms cannot keep up with the chemical etching by F atoms. As the F-to-O ratio is decreased, effective sidewall passivation by O atoms results in nearly vertical sidewalls. A further reduction in the F-to-O ratio results in sidewalls that slope inwards toward the bottom of the feature.
Accurate Measurement of Cellular Autofluorescence is Critical for Imaging of Host-Pathogen Interactions. (2016)

Abstract not provided.
TCP Inigo: Ambidextrous Congestion Control (2016)

No one likes waiting in traffic, whether on a road or on a computer network. Stuttering audio, slow interactive feedback, and untimely pauses in video annoy everyone and cost businesses sales and productivity. An ideal network should (1) minimize latency, (2) maximize bandwidth, (3) share resources according to a desired policy, (4) enable incremental deployment, and (5) minimize administrative overhead. Many technologies have been developed, but none yet satisfactorily address all five goals. The best performing solutions developed so far require controlled environments where coordinated modification of multiple components in the network is possible, but they suffer poor performance in more complex scenarios. We present TCP Inigo, which uses independent delay-based algorithms on the sender and receiver (i.e. ambidextrously) to satisfy all five goals. In networks with single administrative domains, like those in data centers, Inigo's fairness, bandwidth, and latency indices are up to 1.3X better than the best deployable solution. When deployed in a more complex environment, such as across administrative domains, Inigo possesses latency distribution tail up to 42X better.
NRG Oncology CC001: A phase III trial of hippocampal avoidance (HA) in addition to whole-brain radiotherapy (WBRT) plus memantine to preserve neurocognitive function (NCF) in patients with brain metastases (BM). (2019)

2009 Background: NRG CC001, a phase III trial of WBRT plus memantine (WBRT+M) with or without HA, sought to evaluate the neuro-protective effects of lowering the hippocampal radiation dose. Methods: Patients (pts) with BM were stratified by RPA class and prior radiosurgery/surgery and randomized to WBRT+M or HA-WBRT+M (30Gy/10 fractions). Standardized NCF tests were performed at baseline, 2, 4, 6, and 12 months (mos). The primary endpoint was NCF failure, defined as decline using the reliable change index on Hopkins Verbal Learning Test-Revised, Trail Making Test, or Controlled Oral Word Association. Cumulative incidence estimated NCF failure (death without NCF failure was competing risk); between-arms differences tested using Gray’s test. Deterioration at each collection time point was tested using a chi-square test. Patient-reported symptoms were assessed using the MD Anderson Symptom Inventory Brain Tumor module and analyzed using mixed effects models and t-tests. Results: From 7/2016 to 3/2018, 518 pts were randomized. Median follow-up was 7.9 mos. HA-WBRT+M was associated with lower NCF failure risk (adjusted hazard ratio (HR) = 0.74, p = 0.02) due to lower risk of deterioration in executive function at 4 mos (p = 0.01) and encoding (p = 0.049) and consolidation (p = 0.02) at 6 mos. Age≤61 predicted lower NCF failure risk (HR = 0.60, p = 0.0002); non-significant test for interaction indicated independent effects of HA and age. Patient-reported fatigue (p = 0.036), difficulty speaking (p = 0.049) and problems remembering things (p = 0.013) at 6 mos favored the HA-WBRT+M arm. Imputation models accounting for missing data also favored the HA-WBRT+M arm for patient-reported cognition (p = 0.011) and symptom interference (p = 0.008) at 6 mos. Treatment arms did not differ in toxicity, overall survival, or intracranial progression. Conclusions: HA during WBRT+M for BM better preserves NCF and patient-reported symptoms, while achieving similar intracranial control and survival. Supported by grants UG1CA189867 (NCORP), U10CA180868 (NRG Oncology Operations), DCP from the National Cancer Institute. Clinical trial information: NCT02360215.
Ultrafast Demagnetization Dynamics at theMEdges of Magnetic Elements Observed Using a Tabletop High-Harmonic Soft X-Ray Source (2009)

We use few-femtosecond soft x-ray pulses from high-harmonic generation to extract element-specific demagnetization dynamics and hysteresis loops of a compound material for the first time. Using a geometry where high-harmonic beams are reflected from a magnetized Permalloy grating, large changes in the reflected intensity of up to 6% at the M absorption edges of Fe and Ni are observed when the magnetization is reversed. A short pump pulse is used to destroy the magnetic alignment, which allows us to measure the fastest, elementally specific demagnetization dynamics, with 55 fs time resolution. The use of high harmonics for probing magnetic materials promises to combine nanometer spatial resolution, elemental specificity, and femtosecond-to-attosecond time resolution, making it possible to address important fundamental questions in magnetism.
Preclinical Studies of Stem Cell Therapy for Heart Disease (2018)

As part of the TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) series to enhance regenerative medicine, here, we discuss the role of preclinical studies designed to advance stem cell therapies for cardiovascular disease. The quality of this research has improved over the past 10 to 15 years and overall indicates that cell therapy promotes cardiac repair. However, many issues remain, including inability to provide complete cardiac recovery. Recent studies question the need for intact cells suggesting that harnessing what the cells release is the solution. Our contribution describes important breakthroughs and current directions in a cell-based approach to alleviating cardiovascular disease.
On Recurring Debates (1984)

Have you ever noticed how some and ideological debates seem to go on year after year, generation after generation, with same arguments being raised and often with same participants, each time seemingly as if issues were new? Some of these debates, such as one over existence of god, have gone on for millennia with nothing really new being said. An example of this is debate on pornography and politically correct sex, which is part of a larger discussion over general issue of the personal is political. The slogan the personal is political became popular among feminists around 1970. At its most elementary level, this doctrine simply means that one's behavior should not contradict one's ideology. As such, that is just a proscription against hypocrisy and not a prescription to engage in any specific acts or thoughts. This doctrine, while closely identified with modern feminism, had its origins prior to and outside rebirth of feminist movement. The cultural radicals of 1960s, especially Amsterdam Provos and Youth International Party (Yippies) had a slogan live as if Revolution had already happened, a direct precursor of the personal is political. Other antecedents include actions as simple as boycotting lettuce and grapes in support of striking farmworkers. In my own life, reading Henry David Thoreau's On Civil Disobedience, Martin Luther King, Jr.'s Letter from a Birmingham Jail, Albert Camus' Neither Victims Nor Executioners and various essays by A.J. Muste (usually in Liberation) opened me up to importance of closely tying individual actions with belief. I became a draft resister, a tax resister and a participant in many civil disobedience actions. Accepting feminist implications of this came easy, at least intellectually. 301
Isolation of antigen-specific, disulphide-rich knob domain peptides from bovine antibodies (2020)

As a novel alternative to established surface display or combinatorial chemistry approaches for the discovery of therapeutic peptides, we present a method for the isolation of small, cysteine-rich domains from bovine antibody ultralong complementarity-determining regions (CDRs). We show for the first time that isolated bovine antibody knob domains can function as autonomous entities by binding antigen outside the confines of the antibody scaffold. This yields antibody fragments so small as to be considered peptides, each stabilised by an intricate, bespoke arrangement of disulphide bonds. For drug discovery, cow immunisations harness the immune system to generate knob domains with affinities in the picomolar to low nanomolar range, orders of magnitude higher than unoptimized peptides from naïve library screening. Using this approach, knob domain peptides that tightly bound Complement component C5 were obtained, at scale, using conventional antibody discovery and peptide purification techniques.