gebhart/patrepeval huggingface dataset:
Tailor-made ruthenium catalysts for the material use of CO2 in combination with molecular hydrogen (2018)

This doctoral thesis deals with the ruthenium-catalyzed utilization of CO2 in combination with molecular hydrogen. In the first part of this work, the N-methylation of different nitrogen-containing compounds using the ruthenium complex [Ru(triphos)(tmm)] as a catalyst and CO2 and hydrogen for the construction of the methyl groups was investigated. Under optimized reaction conditions, the N-methylation of ammonia, ammonium chloride and nitrobenzenes was successful. In addition, the influence of different substituents in the multicomponent coupling of aldehyde, amine and CO2 was studied. The second part of this work deals with the acid-catalyzed alkylation of amines for the synthesis of phenylpyrrolidines from aromatic amines and cyclic ethers. HNTf2 and Al(OTf)3 were identified as catalysts for this reaction. Under optimized reaction conditions high yields of the corresponding phenylpyrrolidine were obtained starting from primary amines. In addition, an alkyl group transfer was observed using secondary amines and cyclic ethers as substrates. In the third part of this thesis, a novel catalytic synthesis was developed for the preparation of dimethoxymethane (DMM) from methanol, CO2 and hydrogen. The developed reaction pathway provides the first direct reductive access to DMM. A ruthenium triphos complex in combination with a Lewis and/or Brønsted acid as a co-catalyst was identified as a suitable multifunctional catalyst system for the complex reaction sequence. Under optimized reaction conditions a TON of 513 was achieved for DMM. In addition, the developed reaction protocol was successfully used for the synthesis of different dialkoxymethanes from CO2, H2 and the corresponding alcohol. Regarding the reaction pathway, methyl formate and methoxymethanol were identified as intermediates and the construction of the methylene group from CO2 and H2 was clarified by a 13C labeling experiment. Based on these results, the reaction was further investigated using formic acid as a C1 synthon. Under optimized reaction conditions, the TON for DMM could be increased to 1076 starting from formic acid.
355-nm UV Light Generation in High-Quality CsB3O5 Fabricated by Post-Growth Heat Treatment (2005)

Cesium triborate (CsB 3 O 5 ) is expected to be an efficient harmonic generator in the UV region. However, as-grown single crystals of CsB 3 O 5 often contain a high density of optical scattering centers that significantly reduce device performance. We found that these can be removed by a post-growth heat treatment with quenching. Treated crystals were employed for the third harmonic generation of a high-power Nd:YAG laser operating at 1064 nm. We generated high-power 355-nm output power of 14 W, which is three times higher than that obtained by a commercial LiB 3 O 5 crystal under the same experimental conditions.
Compliance and Dead Space Fraction Indicate an Optimal Level of Positive End-Expiratory Pressure After Recruitment in Anesthetized Patients (2008)

All variables showed the positive effects of PEEP in conjunction with a recruitment maneuver. Optimal PEEP was 10 cm H2O because at this pressure level the highest compliance value in conjunction with the lowest dead space fraction indicated a maximum amount of effectively expanded alveoli. FRC and Pao2 were insensitive to alveolar over-distension.
Interligand and charge-transfer emission from [Ru(bpy)(HDPA)2]2+: a dual emitting ruthenium(II) complex (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInterligand and charge-transfer emission from [Ru(bpy)(HDPA)2]2+: a dual emitting ruthenium(II) complexRichard L. Blakley, Michael L. Myrick, and M. Keith. DeArmondCite this: J. Am. Chem. Soc. 1986, 108, 24, 7843–7844Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://pubs.acs.org/doi/10.1021/ja00284a064https://doi.org/10.1021/ja00284a064research-articleACS PublicationsRequest reuse permissionsArticle Views314Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Security for Home Base Station Deployment (2010)

This chapter refers to the deployment of home base stations in EPS - that is, the Home eNodeB (HeNB) - but the differences to Home NodeBs (HNB). It discusses the various security features used for securing the HeNB ecosystem. The chapter describes the procedures to implement these features. Detailed references and technical descriptions of the features are also left to the sections describing the procedures. A section deals with the security related procedures that are executed locally within the HeNB. Security procedures involving the network elements Security Gateway (SeGW) and HeNB Management System (HeMS) are described. The chapter explains the Security Procedures between Home Base Station and Security Gateway. It provides the security aspects of home base station management. The chapter gives an overview of the security-related features of CSG handling, and then covers the complications for emergency call handling caused by HeNBs operating in closed mode. Controlled Vocabulary Terms mobility management (mobile radio); security
Comprehensive tele-ophthalmology screening in vision threatening diseases during COVID-19 (2021)

Purpose : Vision Threatening Diseases (VTD) (age-related macular degeneration [AMD], cataract, diabetic retinopathy [DR], and glaucoma) account for 37% of all blindness. Screening and follow-up are crucial in preserving vision. During COVID-19, clinics reduced access, using telemedicine for diagnosis and follow-ups. The efficacy of remote screening and triage in the management of single or multiple VTDs was evaluated. Methods : We screened 41 subjects (19-85 years, 37% male, 17% Caucasian) (20 controls, 21 subjects). Demographics, 45-degree retinal photos, ganglion cell complex (GCC), and optic nerve head (ONH) images were collected using a non-contact puff-tonometer, nonmydriatic retinal camera, and an OCTA. Demographics and images were transmitted to two readers (onsite telemedicine screener [TS] and remote ophthalmologist [RO]) for triage. Triage was categorized: immediate referral to specialist, follow-up in person via clinic or telemedicine visit, or no follow-up necessary during COVID. Results : TS made 19 referrals (46%), 6 in person follow-ups (15%), 15 no follow-ups (37%);RO made 17 referrals (41%), 2 in person follow-ups (5%), 22 no follow-ups (54%). TS identified 12 subjects as possible VTD(s) while RO identified 11 subjects. TS and RO agreed on 8 glaucoma, 7 cataract, 3 DR, and 3 and 2 AMD cases, respectively. Glaucoma was identified using IOPs, retinal fundoscopy, and OCT imaging. Mean intraocular pressures were 12.9 and 15.7 (OD, OS) in glaucoma and 14.2 and 14.0 in controls. Fundoscopy was used for overall retinal health while OCT images were used to analyze GCC, ONH, nerve fiber layer, cup to disc ratio, and anterior chamber angles. AMD and DR were identified by fundoscopy and OCT imaging. 11 of the subjects were known clinic patients;both RO and TS referred all 11 to specialty clinics, matching the in-person clinic management. Conclusions : During the COVID pandemic, triaging patients can minimize person-toperson contact and help control the spread of the virus. Both readers agreed on the management and triage of a variety of patients with TS and RO differing only on 2 referrals and 4 in person follow-ups. Telemedicine is a promising alternative to in-person patient care for management and triage of vision threatening diseases. Further enrollment and follow-up are needed to increase robustness.
Reduction in Contact Resistance of Pentacene Thin-Film Transistors by Formation of an Organo-Metal Hybrid Interlayer (2009)

We propose a viable method of reducing the contact resistance of organic electronic devices by the formation of an organo-metal hybrid interlayer between a metal electrode and an organic semiconducting layer. The hybrid interlayer is produced by simultaneous deposition of the same materials as the electrode and the organic semiconductor, without any extra buffer layer. In such a hybrid interlayer, the metal clusters are uniformly dispersed on entangled organic surfaces so that they contribute significantly to the reduction of the contact resistance. The contact resistance is reduced by about a factor of seven. A simple theoretical model, based on the carrier accumulation and tunneling effects, well describes the essential features of the contact resistance as a function of the thickness of the hybrid interlayer.
Ammonifex thiophilus sp. nov., a hyperthermophilic anaerobic bacterium from a Kamchatka hot spring (2008)

A novel anaerobic, extremely thermophilic, facultatively chemolithoautotrophic bacterium designated strain SRT was isolated from a terrestrial hot spring in Kamchatka (Russia). The cells of the novel strain were spore-forming rods with a Gram-positive type of cell wall. The novel isolate grew at 60–82 °C (optimum 75 °C) and pH 6.0–7.5 (optimum 6.8). Molecular hydrogen and formate were used as electron donors. Thiosulfate, sulfate or elemental sulfur served as electron acceptors yielding hydrogen sulfide. No growth was observed on either substrate in the presence of nitrate as the electron acceptor. The G+C content of the DNA was 56.2 mol%. Phylogenetic analyses of the 16S rRNA gene showed that strain SRT was most closely related to Ammonifex degensii (96.4 % gene sequence similarity). However, the novel isolate possessed phenotypic characteristics that differed significantly from those of A. degensii, the only other recognized species of the genus Ammonifex. It is concluded that strain SRT (=DSM 19636T=VKM B-2461T) represents the type strain of a novel species of the genus Ammonifex, for which the name Ammonifex thiophilus sp. nov. is proposed. An emendation of the genus Ammonifex is proposed based on the phenotypic characteristics of the novel species.
24-HOUR PERIODICITY OF ADRENAL CORTEX (1955)

24-hour periodicity in circulating eosinophils and urinary excretion of 17-ketosteroids and total 17-hydroxycorticoids in normal subjects were studied.1) The maximal level of circulating eosinophils was observed at midnight and minimal one at noon.2) The maximal excretion of urinary 17-ketosteroids wa s observed during the morning hour (06: 00-09: 00) and minimal one at the time period just before awakening (03: 00-06: 00).3) The feature of the rhythm of urinary total 17-hydroxycorticoids was similar to that of 17-ketosteroids.The maximal value was observed at the same time as 17-ketosterids (06: 00-09: 00), but minimal one at midnight (00: 00-03: 00).4) The correlation coefficient between relative value of circulating eosinphils and that of 17-ketosteroids or 17-hydroxycorticoids are -0.343 and -0.307 respectively. These figures are not large, but statistically significant below 1% level.
Investigación y medicamentos: reto y oportunidad para los países en desarrollo (2006)

Como dijo Juan Pablo II, pueblo mas ricos y tecnologicamente mas avanzados tienen que saber escuchar grito de tantos pueblos en mundo, praa lo que, segun expreso san Josemaria, el estudiar con profundidad cientifica los problemas remueve tambien los corazones, espolea la pasividad, despierta fuerzas que dormitan y forma ciudadanos dispuestos a construir una sociedad mas justa. Estas ideas son las que impulsaron al autor a preparar las lineas que siguen, que fueron hace unas semanas la Leccion inaugural del curso academico 2006-07 en la Universidad de Navarra.
Management of Vascular Risk Factors: An Undertreated Opportunity for Stroke Prevention (2001)

P150 Purpose: To assess the quality of risk factor management before and after ischemic cerebrovascular disease. Methods: Records of 100 consecutive patients seen by the Stroke Service for TIA or stroke were reviewed. Control of modifiable risk factors including hypertension (HTN), hyperglycemia (DM), hypercholesterolemia (HCh), and obesity were recorded in the 3 months before the event (T-0), immediately after the event (T-1), and one year later (T-2). Not every risk factor was recorded in each time epoch for each patient. Results: History of HTN was present in 76, DM in 29, HCh in 33, and obesity in 45. At T-0, 33/71 had systolic blood pressure (SBP) &gt;140, 23/64 had total cholesterol &gt;200, 17/57 had LDL cholesterol &gt;130, 10/22 had HbA1c &gt;8 and 41/66 had body mass index (BMI) &gt;25. At T-1, 72 patients had SBP ≥135. At T-2, only 19/72 controlled the SBP &lt;140. Of the patients with known DM and a recorded HbA1c at T-1, 14/21 were ≥8. At T-2, 6/20 were ≥8. Of the 66 patients with no history of HCh, 16 had total cholesterol ≥200 and 8 had LDL ≥130 at T-0. Of those with known HCh, 11 had total cholesterol ≥200 and 9 had LDL ≥130 at T-0. At T-2, there were no data on LDL on 50 patients, while 30 had ≥100 and 9 were ≥130. Using body mass index (BMI) ≥25 as a marker for obesity, 45 of 62 patients were obese at T-1. At T-2, there were still 45/62 with a BMI ≥25. Conclusions: The majority of patients had at least one risk factor in poor control prior to the stroke or TIA. Our data indicate that risk factor management for primary prevention of stroke has considerable room for improvement. Following the stroke/TIA, management of DM, the area of our greatest risk management success, failed to achieve satisfactory control in 30% of patients at the end of 1 year. Treatment of obesity was our worst area, with no improvement from baseline. The 40% and 43% success rates for HCh and SBP are less than satisfactory. Our data indicate that stroke prevention may be enhanced with more aggressive management of known risk factors. While this study suffers from the problems inherent in small retrospective series, if validated by other studies, the implications are important.
Graphene microheater for phase change chalcogenides based integrated photonic components [Invited] (2022)

In order to effectively control the state of an active integrated photonic component based on chalcogenide phase change materials, an efficient microheater operating at low voltage is required. Here, we report on the design of a graphene based microheater. The proposed system contains two separate graphene layers between which the phase change material cell of Ge 2 Sb 2 Te 5 is placed. Three distinct switching possibilities are explored, using only the bottom layer, only the top layer or both graphene layers. A detailed investigation of the heater parameters is performed to optimise switching performance. A self-consistent multiphysics simulation of the crystallization process in the phase change material cell is conducted demonstrating the switching capabilities of the proposed design.
Athletic Injuries of the Wrist (1985)

The wrist is at risk for injury in many athletic endeavors, often in acute falls or dorsiflexion injuries and at other times from repetitive stress involved with fitness routines or specific motions called for in the sport. Dorsiflexion accounts for most wrist problems giving rise to compression injuries dorsally such as scaphoid impaction, triquetrohamate impaction, and occult ganglions. These are seen most often in weight lifters, gymnasts, and push-up enthusiasts. Tension injuries occur on the palmar aspect of the wrist with disruption or attenuation of the supporting ligaments or interosseous membranes. This provides scapholunate tears, scapholunate dissociation, lunatotriquetral, midcarpal instability problems, and so forth, which are generally the result of single energetic injuries commonly associated with contact sports. Distal radioulnar injuries include chondromalacia of the ulnar head, ulnar head subluxation, and ulnocarpal impingements with tears of the triangular fibrocartilage. Forceful rotational injuries are generally associated with the former and stressful ulnar deviation with the latter, where tennis players and baseball batters are at risk. Fracture of the hook of the hamate and pisotriquetral chondromalacia are common in sports requiring holding a club, handle, or bat. Precise, early diagnosis affords the best chance for successful treatment.
The Hidden Difficulties of Watching and Rebuilding Networks (2008)

The subtleties of network protection can bedevil even experienced IT staff and security researchers. In this installment of secure systems, we focus on two areas of network defense that are particularly troublesome to manage: network intrusion recovery and ubiquitous network monitoring.
A Manifesto for Future Generation Cloud Computing (2018)

The Cloud computing paradigm has revolutionised the computer science horizon during the past decade and has enabled the emergence of computing as the fifth utility. It has captured significant attention of academia, industries, and government bodies. Now, it has emerged as the backbone of modern economy by offering subscription-based services anytime, anywhere following a pay-as-you-go model. This has instigated (1) shorter establishment times for start-ups, (2) creation of scalable global enterprise applications, (3) better cost-to-value associativity for scientific and high-performance computing applications, and (4) different invocation/execution models for pervasive and ubiquitous applications. The recent technological developments and paradigms such as serverless computing, software-defined networking, Internet of Things, and processing at network edge are creating new opportunities for Cloud computing. However, they are also posing several new challenges and creating the need for new approaches and research strategies, as well as the re-evaluation of the models that were developed to address issues such as scalability, elasticity, reliability, security, sustainability, and application models. The proposed manifesto addresses them by identifying the major open challenges in Cloud computing, emerging trends, and impact areas. It then offers research directions for the next decade, thus helping in the realisation of Future Generation Cloud Computing.
Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease (2020)

γ-Secretase (GS) is a key target for the potential treatment of Alzheimer's disease. While inhibiting GS led to serious side effects, its modulation holds a lot of potential to deliver a safe treatment. Herein, we report the discovery of a potent and selective gamma secretase modulator (GSM) (<i>S</i>)-<b>3</b> (RO7185876), belonging to a novel chemical class, the triazolo-azepines. This compound demonstrates an excellent in vitro and in vivo DMPK profile. Furthermore, based on its in vivo efficacy in a pharmacodynamic mouse model and the outcome of the dose range finding (DRF) toxicological studies in two species, this compound was selected to undergo entry in human enabling studies (e.g., GLP toxicology and scale up activities).
Still image compression method based on adaptive block segmentation vector quantization technique (2004)

In order to increase the performance of image compression by vector quantization (VQ), we have developed a new still image compression algorithm. Adaptive block segmentation vector quantization (ABS-VQ) method, which is composed of three key techniques, i.e., the resolution conversion, the quad tree data structure and the mean-residual VQ, can realize much superior compression performance than the worldwide standard JPEG and JPEG-2000. On the compression of the XGA (1024/spl times/768 pixels), SXGA (1280/spl times/1024 pixels) and UXGA (1600/spl times/1200 pixels) images including text, for instance, there exists the overwhelming performance superiority of more than 5 dB in compressed image quality.
Inhibition of interleukin‐6 signaling by galiellalactone (2000)

A search for inhibitors of the IL-6-mediated signal transduction in HepG2 cells using secreted alkaline phosphatase (SEAP) as reporter gene resulted in the isolation of galiellalactone (1) from fermentations of the ascomycete strain A111-95. Galiellalactone inhibits the IL-6-induced SEAP expression with IC(50) values of 250-500 nM by blocking the binding of the activated Stat3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the Stat3 transcription factor. Due to its selective activity, galiellalactone may serve as a lead compound for the development of new therapeutic agents for diseases originating from the inappropriate expression of IL-6 and as molecular tool to dissect the JAK/STAT pathways.
A system level approach to a structured MCM design methodology (2002)

The implementation of complex electronic systems using high density packaging (HDP) technologies requires an IC-like "right first-time" design approach, as rework and prototyping for such technologies can be extremely expensive. Highly integrated and versatile MCM design environments, able to provide an automated design data flow and to cope with the required flexibility, are therefore a necessity. Available MCM CAD tools are an adaptation of PCB tools, and cannot provide the required features. This paper points out these limitations and outlines a minimum set of features for an optimized MCM design environment. The paper also describes the development of one such environment, tailored for MCM-D technologies.
Numerical investigation on spatial coherent matched detection for detection of spatially multiplexed signals (2019)

Spatial division multiplexing (SDM) is crucial for ultra-high capacity optical fiber transmission. In addition to SDM using multi-core fiber, multi-modal multiplexing using multi-mode fiber is another option. MDM and OAM are intensively investigated. For any SDM transmission, typical ways are based on optical fan-in and -out devices for multiplexing and demultiplexing tributaries. In this paper, spatial coherent matched detection is investigated for showing the capability of multi-modal coherent detection, where such SDM signals are received without using optical fan-out devices. Numerical proof focusing on reception of high-speed SDM coherent multilevel signals is provided.