gebhart/patrepeval huggingface dataset:
Confinement-induced super strong PS/MWNT composite nanofibers (2008)

Shear Modulation Force Microscopy (SMFM) together with the Atomic Force Microscopy (AFM) based three-point bending technique were used to measure the mechanical properties of electrospun polymers and polymer nanocomposite fibers. Both techniques showed that the moduli of the fibers increased significantly with decreasing fiber diameter. We attributed this enhancement to the orientation of polymer chains which occurs during the electrospinning process. We then predicted, and confirmed experimentally, that the phenomenon scales with Rg rather than with the absolute fiber diameter and can propagate radially for large distances (~20Rg) into the fiber interior. The inclusion of nanotubes into the fibers further enhanced the orientation by introducing additional surfaces. The additional increase in modulus (more than an order of magnitude) could then be explained by the same model and scaled on a universal curve.
Comparison of the current renal staging, progression and response criteria to predict renal survival in AL amyloidosis using a Mayo cohort (2021)

Three sets of criteria (International Society of Amyloidosis [ISA], Palladini and Kastritis) were independently developed for staging, progression and response criteria to predict renal survival in patients with AL amyloidosis. We evaluated these criteria using a cohort of 495 newly diagnosed AL amyloidosis patients with renal involvement using time to event competing risk analysis at baseline, 3, 6 and 12 months after treatment. Only Palladini and Kastritis had a staging system and both predicted a higher risk of end stage renal disease (ESRD) in the stage III vs stage I patients but only the Palladini model was predictive for stage II patients. At 3 months, risk of ESRD was significantly higher for Palladini and ISA renal progression (hazard ratio [HR] 2.8 [95% CI: 1.5-5.3, p = .001] and 2.5 [CI: 1.4-4.6, p = .004, respectively]), but renal response was not significantly protective; conversely, the risk of ESRD was not significantly higher for the Kastritis renal progression, but was significantly protective for the Kastritis renal responders (HR 0.38 [95% CI: 0.17-0.84], p = .017). Both progression and response with ISA, Palladini and Kastritis criteria were predictive of ESRD at 6 months and 12 months. While the Palladini staging criteria at baseline, and the ISA and Palladini criteria for progression at 3 months performed better than the Kastritis criteria at baseline and 3 months post-treatment, the Kastritis criteria performed better for response 3 months after treatment. All three sets of criteria performed well at and after 6 months post-treatment. These differences are important when choosing endpoints for clinical trials.
Effect of ${\rm Ca}^{2+}{\rm Co}$-Doping on the Temperature Dependence of ${\rm Gd}_{2}{\rm SiO}_{5}:{\rm Ce}$ Photoluminescence (2013)

The temperature dependence of the photoluminescence properties of <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\rm Gd}_{2}{\rm SiO}_{5}:{\rm Ce},{\rm Ca}$</tex></formula> crystals was found to be significantly affected by Ca codoping and shows that presence of additional energy levels in these crystals provides nonradiative energy transfer. The excitation and emission bands also broaden with codoping due to presence of these additional energy levels. Therefore Ca codoping in <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\rm Gd}_{2}{\rm SiO}_{5}$</tex></formula> crystals decreases the scintillation decay very strongly and has a strong adverse affect on scintillation light yield, different from the effect in other members of the oxyorthosilicate family such as <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\rm Lu}_{2}{\rm SiO}_{5}$</tex> </formula> and <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\rm Y}_{2}{\rm SiO}_{5}$</tex></formula> .
Geometric Properties of Optimal Photonic Crystals (2008)

Photonic crystals can be designed to control and confine light. Since the introduction of the concept by Yablonovitch and John two decades ago, there has been a quest for the optimal structure, i.e., the periodic arrangement of dielectric and air that maximizes the photonic band gap. Based on numerical optimization studies, we have discovered some surprisingly simple geometric properties of optimal planar band gap structures. We conjecture that optimal structures for gaps between bands n and n+1 correspond to n elliptic rods with centers defined by the generators of an optimal centroidal Voronoi tessellation (transverse magnetic polarization) and to the walls of this tessellation (transverse electric polarization).
Determination of equivalent conductivity of metallized plastic antenna elements in Ka band (2016)

The term “equivalent conductivity” has been used in this paper for characterization of metallized plastic antenna components in Ka band. The measured values of this parameter can be used to replace the bulk conductivity of metal bodies in the 3-D simulators for implementation of better simulations of the metallized plastic antenna structures. A resonance method is proposed for determination of the equivalent conductivity, which is based on measurements of unloaded Q factors of modes in resonators with minimized surface-to-volume ratio with only one flat wall formed by the metal surface under test. Finally, comparative data have been presented for electroplated or electroless metallized plastic samples made by injection molding.
Estimation of current distribution by near-field measurement (2009)

Approaches to estimate the current distribution on EM source such as antennas and printed circuit board (PCB) by measuring the near-field distribution are demonstrated. These approaches include the matrix inversion method and sampled pattern matching (SPM) method. All of these approaches require accurate near-field measurement and field-current inverse algorithm. Experimental results are presented and compared with the numerical results, confirming the accuracy and performance of these methods.
Comparison of Anterior Cervical Discectomy and Fusion to Posterior Cervical Foraminotomy for Cervical Radiculopathy: Utilization, Costs, and Adverse Events 2003 to 2014 (2018)

Within the inherent limitations of administrative data, our findings suggest an opportunity for value improvement in managing cervical radiculopathy and indicate a need for large-scale comparative study of clinical outcomes and costs.
Gene Expression Profiling in a Model of d-Penicillamine-Induced Autoimmunity in the Brown Norway Rat:  Predictive Value of Early Signs of Danger (2005)

Idiosyncratic drug reactions (IDRs) cause significant morbidity and mortality. In an animal model of IDRs, 50-80% of Brown Norway rats exposed to D-penicillamine develop an autoimmune syndrome after several weeks of treatment. The symptoms of the IDR are similar to that observed in humans who take D-penicillamine. The mechanism of this reaction is unknown, and no effective biomarkers have been identified to predict susceptibility. We postulate that cell stress caused by drugs is required to initiate the response. We used a high-throughput approach to identify factors that might represent danger signals by profiling hepatic gene expression 6 h after dosing with D-penicillamine (150 mg/kg). Our results show that the drug-treated animals cluster into two distinct groups. One group exhibits substantial expression changes relative to control animals. The most significantly altered transcripts have a role in stress, energy metabolism, acute phase response, and inflammation. We used quantitative reverse transcriptase polymerase chain reaction to measure transcript levels in liver biopsies of 33 rats and found that resistant animals cluster together. This "resistant" cluster of animals contains 87.5% (7/8) resistant animals but only 48% (12/25) "sensitive" animals. This separation is statistically significant at the p = 0.01 level.
Freeze fracture imaging and computer simulation of liposome structure: Membrane geometry and defects (1983)

At low weight fractions, many surfactant and biological amphiphiles form dispersions of lamellar liquid crystalline liposomes in water. Amphiphile molecules tend to align themselves in parallel bilayers which are free to bend. Bilayers must form closed surfaces to separate hydrophobic and hydrophilic domains completely. Continuum theory of liquid crystals requires that the constant spacing of bilayer surfaces be maintained except at singularities of no more than line extent. Maxwell demonstrated that only two types of closed surfaces can satisfy this constraint: concentric spheres and Dupin cyclides. Dupin cyclides (Figure 1) are parallel closed surfaces which have a conjugate ellipse (r 1 ) and hyperbola (r 2 ) as singularities in the bilayer spacing. Any straight line drawn from a point on the ellipse to a point on the hyperbola is normal to every surface it intersects (broken lines in Figure 1). A simple example, and limiting case, is a family of concentric tori (Figure 1b). To distinguish between the allowable arrangements, freeze fracture TEM micrographs of representative biological (L-α phosphotidylcholine: L-α PC) and surfactant (sodium heptylnonyl benzenesulfonate: SHBS)liposomes are compared to mathematically derived sections of Dupin cyclides and concentric spheres.
TheRNA‐binding proteinMARTA2 regulates dendritic targeting ofMAP2mRNAs in rat neurons (2012)

Dendritic targeting of mRNAs encoding the microtubule-associated protein 2 (MAP2) in neurons involves a cis-acting dendritic targeting element. Two rat brain proteins, MAP2-RNA trans-acting protein (MARTA)1 and MARTA2, bind to the cis-element with both high affinity and specificity. In this study, affinity-purified MARTA2 was identified as orthologue of human far-upstream element binding protein 3. In neurons, it resides in somatodendritic granules and dendritic spines and associates with MAP2 mRNAs. Expression of a dominant-negative variant of MARTA2 disrupts dendritic targeting of endogenous MAP2 mRNAs, while not noticeably altering the level and subcellular distribution of polyadenylated mRNAs as a whole. Finally, MAP2 transcripts associate with the microtubule-based motor KIF5 and inhibition of KIF5, but not cytoplasmic dynein function disrupts extrasomatic trafficking of MAP2 mRNA granules. Thus, in neurons MARTA2 appears to represent a key trans-acting factor involved in KIF5-mediated dendritic targeting of MAP2 mRNAs.
Exchange-biased magnetic tunnel junctions: Dependence of offset field on junction width (1999)

Magnetic tunnel junction structures comprising a ferromagnetic layer pinned by exchange biasing and a “free” ferromagnetic layer were prepared using dc-magnetron sputtering and patterned with conventional optical lithography. Structures were prepared, square and rectangular in shape, with various widths and lengths. It was observed that the magnetic properties of the free layer vary systematically with the size of the junction. In particular, the offset field of the free-layer magnetic hysteresis loop, as measured resistively, is controlled by a combination of magnetostatic and ferromagnetic coupling between the pinned and free layers.
Design, Synthesis and Biological Evaluation of Novel 5H-Chromenopyridines as Potential Anti-Cancer Agents (2015)

A novel series of 5H-chromenopyridines was identified as anticancer agents in our continuing effort to discover and develop new small molecule anti-proliferative agents. Based on our initial lead SP-6-27 compound, we designed and synthesized novel tricyclic 5H-thiochromenopyridine and 5H-chromenopyridine analogs to evaluate the impact of an additional ring, as well as conformational flexibility on cytotoxic activity against human melanoma and glioma cell lines. All of the 5H-thiochromenopyridines have been achieved in good yields (89%-93%) using a single-step, three-component cyclization without the need for purification. The 5H-chromenopyridine analog of the potent 5H-thiochromenopyride was obtained in a good yield upon purification. All newly-prepared 5H-thiochromenopyridines showed good to moderate cytotoxicity against three melanoma and two glioma cell lines (3-15 μM). However, the 5H-chromenopyridine analogue that we prepared in our laboratory lost cytotoxic activity. The moderate cytotoxic activity of 5H-thiochromenopyridines shows the promise of developing chromenopyridines as potential anticancer agents.
Curcumin: A natural derivative with antibacterial activity against Clostridium difficile (2019)

The findings suggest that curcumin has potential as an anti-clostridial agent. More work is needed to further investigate the efficacy of curcumin as a stand-alone drug or as a supplement of current drugs of choice, as it has no antagonistic activities but might overcome their drawbacks.
Joint pilot sequence design and power control for Max-Min fairness in uplink massive MIMO (2017)

This paper optimizes the pilot assignment and pilot transmit powers to mitigate pilot contamination in Massive MIMO (multiple-input multiple-output) systems. While prior works have treated pilot assignment as a combinatorial problem, we achieve a more tractable problem formulation by directly optimizing the pilot sequences. To this end, we compute a lower bound on the uplink (UL) spectral efficiency (SE), for Rayleigh fading channels with maximum ratio (MR) detection and arbitrary pilot sequences. We optimize the max-min SE with respect to the pilot sequences and pilot powers, under power budget constraints. This becomes an NP-hard signomial problem, but we propose an efficient algorithm to obtain a local optimum with polynomial complexity. Numerical results manifest the near optimality of the proposed algorithm and show significant gains over existing suboptimal algorithms.
Measurement of the π−-Ar total hadronic cross section at the LArIAT experiment (2022)

We present the first measurement of the negative pion total hadronic cross section on argon in a restricted phase space, which we performed at the Liquid Argon In A Testbeam (LArIAT) experiment. All hadronic reaction channels, as well as hadronic elastic interactions with scattering angle greater than 5\ifmmode^\circ\else\textdegree\fi{} are included. The pions have kinetic energies in the range 100--700 MeV and are produced by a beam of charged particles impinging on a solid target at the Fermilab test beam facility. LArIAT employs a 0.24 ton active mass liquid argon time projection chamber (LArTPC) to measure the pion hadronic interactions. For this measurement, LArIAT has developed the ``thin slice method,'' a new technique to measure cross sections with LArTPCs. While moderately higher, our measurement of the ${\ensuremath{\pi}}^{\ensuremath{-}}$-Ar total hadronic cross section is generally in agreement with the geant4 prediction.
Painting Supramolecular Polymers in Organic Solvents by Super-resolution Microscopy (2018)

Despite the rapid development of complex functional supramolecular systems, visualization of these architectures under native conditions at high resolution has remained a challenging endeavor. Super-resolution microscopy was recently proposed as an effective tool to unveil one-dimensional nanoscale structures in aqueous media upon chemical functionalization with suitable fluorescent probes. Building upon our previous work, which enabled photoactivation localization microscopy in organic solvents, herein, we present the imaging of one-dimensional supramolecular polymers in their native environment by interface point accumulation for imaging in nanoscale topography (iPAINT). The noncovalent staining, typical of iPAINT, allows the investigation of supramolecular polymers' structure in situ without any chemical modification. The quasi-permanent adsorption of the dye to the polymer is exploited to identify block-like arrangements within supramolecular fibers, which were obtained upon mixing homopolymers that were prestained with different colors. The staining of the blocks, maintained by the lack of exchange of the dyes, permits the imaging of complex structures for multiple days. This study showcases the potential of PAINT-like strategies such as iPAINT to visualize multicomponent dynamic systems in their native environment with an easy, synthesis-free approach and high spatial resolution.
Direct and one-pot conversion of polyguluronates and alginates into alkyl-l-guluronamide-based surfactant compositions (2016)

One-pot transformation of <sc>l</sc>-polyguluronates or alginates into 100% bio-based surfactants proceeded efficiently to provide novel long-chain alkyl-<sc>l</sc>-guluronamide/<sc>d</sc>-mannuronamide compositions as emulsion stabilizers.
Oil Free Machinery and “Zero Wear”- Dream or Reality? (2011)

Original equipment manufacturers (OEMs) and end-users perceive “Zero Wear” differently. The “Zero Wear” approach will be put into a general relation for different applications and illuminated by individual paths, either based on monolithic materials, thin film coatings or alternative base oils, featuring triboactive materials and lubricious oxides for tribological engine components and dry running foil bearings or specific DLC, ta-C and novel Zirconium-based thin film coatings for concentrated contacts above FZG 14 and alternative engine oils (NoSAP & bio-no-tox). The associated tribometric test equipments for these examples will also be detailed.
Alterations in elastin and collagen related to the mechanism of progressive pulmonary venous obstruction in a piglet model. A hemodynamic, ultrastructural, and biochemical study. (1990)

We created an animal model to understand better the pathogenesis and underlying mechanism of progressive central pulmonary venous (PV) obstruction, a condition not amenable to current therapy. Twenty piglets underwent banding of their PVs, 18 had a sham operation, and 12 were nonoperated controls. After 1, 3, and 6 weeks hemodynamic data were obtained and correlated with ventricular weights, PV and pulmonary artery (PA) distensibilities (at 1 week), morphometric structural and ultrastructural analyses, and biochemical assessment of elastin determined gravimetrically (and by desmosine level at 1 week), collagen, and elastase activity. At 1 week, PV banding was associated with increased PV compliance (p less than 0.05). At 3 weeks, an increased PA pressure (Ppa) (p less than 0.05) was observed, unaccompanied by a rise in PV pressure (Pcw). In the PV, however, there was breakdown of the internal elastic lamina with apparent migration of smooth muscle cells from media to subendothelium. At 6 weeks, a rise in Pcw (p less than 0.01), a further rise in Ppa (p less than 0.01), and right ventricular hypertrophy (p less than 0.005) were observed. We also observed mild PV intimal thickening (p less than 0.01), complete degradation of elastic laminae (p less than 0.05), and an increase in collagen assessed morphometrically (p less than 0.01). The banding procedure resulted in an overall increase in PV elastin synthesis and in the proportion of elastin determined gravimetrically (p less than 0.05 for both) but not by desmosine level, suggesting the possibility of poor cross-linking of elastin, which might account for the early increased distensibility of the PV. However, our assay could not detect an increase in elastase activity associated with either the increased distensibility or the ultrastructural changes of elastin degradation. The increased Ppa was not associated with significant PA biochemical or structural changes. We speculate that in response to distal venous obstruction, early remodeling of the PVs increases distensibility, protecting the lung from venous congestion and blunting a rise in Pcw. PA hypertension precedes the rise in Pcw, likely because of reflex vasoconstriction. The subsequent modest rise in Pcw is already associated with extensive fibrosis of the PV, suggesting a reason for unsuccessful current therapy and a need for consideration of earlier assessment and intervention.
Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults (2018)

ClinicalTrials.gov NCT02599896.
Arsenic Adsorptive Media Technology Selection Strategies (2006)

Abstract More stringent arsenic regulations are requiring water utilities of all sizes to install treatment systems on wells which historically only had chlorination. A case study is presented for evaluating arsenic adsorption media at a well site in Mesa, Arizona, but the approach and methodological conclusions are transferable to any arsenic treatment system. The goal of this project is to develop a comprehensive, cost-effective and rapid approach for selecting arsenic adsorptive media. Batch laboratory tests, labscale continuous flow column tests and pilot-scale tests were conducted to evaluate removal efficiency, robustness, operational benefits and cost effectiveness of eight different commercially available adsorbents. Batch tests conducted at multiple pH levels provided limited benefit when compared against continuous flow rapid small-scale column tests (RSSCTs) to evaluate arsenic removal capability by different media. Breakthrough curves of arsenic, vanadium, silica and other trace metals corresponded well between lab-scale RSSCT and field-based pilot scale, suggesting that RSSCTs offer a timesaving approach for adsorptive media selection. Leaching tests on spent media verified that media could be safely disposed and high-resolution microscopic analysis indicated that calcium and silica accumulate on media surfaces and affect the longevity of arsenic removal systems.
Using your ADC and Backend Capacitors to Authenticate for Free: (Virtually) Free from Database, Enrollment, and Excessive Area/Power Overhead (2019)

Detection of counterfeit chips has emerged as a crucial concern. Physically-unclonable-function (PUF)-based techniques are widely used for authentication, however, require dedicated hardware and large signature database. In this work, we show intrinsic &amp; database-free authentication using back-end capacitors. The discussed technique simplifies authentication setup and reduces the test cost. We show that an analog-to-digital converter (ADC) can be modified for back-end capacitor-based authentication in addition to its regular functionality; hence, a dedicated authentication module is not necessary. Moreover, since back-end capacitors are quite insensitive to temperature and aging-induced variations than transistors, the discussed technique result in a more reliable authentication than transistor PUF-based authentication. The modifications to conventional ADC incur 3.2% power overhead and 75% active-area overhead; however, arguably, the advantages of the discussed intrinsic &amp; database-free authentication outweigh the overheads. Full version of this article is published at IEEE TVLSI.
Correction to: Utilisation of an operative difficulty grading scale for laparoscopic cholecystectomy (2018)

The list of the CholeS management group, Collaborators and Data Validators were omitted from the Acknowledgments.