gebhart/patrepeval huggingface dataset:
Abstract CT165: Phase II open label trial of minnelide™ in patients with chemotherapy refractory metastatic pancreatic cancer (2019)

BackgroundTriptolide and its water-soluble prodrug, Minnelide™, have shown promising activity against pancreatic ductal adenocarcinoma (PDAC) in both in vitro and in vivo experiments. Triptolide induces apoptosis in pancreatic cancer cells by different pathways, including caspase-dependent apoptotic death and caspase -independent autophagic death. It inhibits the activity of the TFIIH general transcription factor complex and modulates the transcriptional landscape of both the stroma and cancer cell compartments. In the epithelial tumour compartment, triptolide down-regulates key transcription factors such as c-MYC. In the phase I clinical trial of Minnelide™ significant activity in highly refractory metastatic pancreatic carcinoma was observed. Hence we undertook this study in patients with chemotherapy refractory metastatic PDAC.MethodsEligibility criteria include stage IV PDAC that has progressed on standard chemotherapy, Karnofsky performance status ≥ 70%, and measurable disease. Planned sample size is up to 35 patients with interim analysis after the first 18 evaluable patients, aiming for at least a 20% difference in DCR (10% v 30%). Minnelide™ 0.67 mg/m2 is administered intravenously over 30 minutes on days 1-21, followed by a 7 day rest period in a 28 day cycle. Exploratory objectives include: analysis of tumor texture on radiologic scans as a non-invasive biomarker for response, as well as analyses of paired tumour biopsies for changes in immune cell infiltration, stromal activation, chromatin accessibility, phopshoproteomics and metabolism. # NCT03117920The trial opened 4/2017 and as of 12/2018, 18 patients have been treated. Supported by SU2C, Cancer Research UK, Lustgarten FoundationCitation Format: David Propper, Haiyong Han, Daniel Von Hoff, Erkut Borazanci, Tannishtha Reya, Jonathan Ghergurovich, Irina Pshenichnaya, Corina Antal, Rachel Condjella, Shreya Sharma, Peter O'Dwyer, Trevor Littlewood, Hitendra Patel, Ashok Saluja, Mohana Velagapudi, Lifeng Yang, Michael Downes, Ronald Evans, Gerard Evan. Phase II open label trial of minnelide™ in patients with chemotherapy refractory metastatic pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr CT165.
Torque modeling and optimization of DC machine based on reluctance network taking into account armature reaction magnetic field (2015)

In this paper, the main objective is to develop a fast analytical model to be used in optimization process or coupled with other fast analytical models. A reluctance network of DC series machine is developed and shows its accuracy and robustness thanks to the consideration of the armature magnetic reaction (AMR) which is an important phenomenon in high saturated DC motors. This model is validated by a statistical way and presents a fast computation time thanks to an equivalent symmetrical machine. The optimization is used with RN and FE models and shows the efficiency of the RN to find an optimum without needing the FE final step optimization.
Novel hybrid membranes by incorporating SiO2 nanoparticles using in situ microemulsion polymerization: preparation, characterization and enhancement in the performance for CO2/N2 (2015)

SiO<sub>2</sub>/PMMA membranes by <italic>in situ</italic> microemulsion polymerization showed high separation performance, due to the good distribution of small SiO<sub>2</sub> in the polymer.
A novel inverter topology for compact EV and HEV drive systems (2013)

This paper describes a new modular inverter topology suitable for compact drive systems in electric road vehicles. The topology is based on dc-side cascading of three-phase two-level inverter bridges, each feeding a set of three-phase windings of a motor. This topology is compared by calculation to the known modular high-frequency (MHF) converter, and is found to have similar losses and semiconductor expenditure requirements. Simulations verify the dynamic and static properties of the converter in a realistic application.
Nonlocal effects on second harmonic generation in low-damping epsilon-near-zero slabs (2013)

We predict enhanced second-harmonic generation in low-damping epsilon-near-zero slabs made of plasmonic nanoshells. We further discuss the contribution of nonlocal effects induced by free-electron gas pressure in metals to the nonlinear response of the slab. © OSA 2013.
Further Utilization of Mucohalic Acids:  Palladium-Free, Regioselective Etherification and Amination of α,β-Dihalo γ-Methoxycarbonyloxy and γ-Acetoxy Butenolides (2003)

Palladium-free etherification and amination of mucohalic acid methyl carbonates 1e (3,4-dichloro-5-methoxycarbonyloxy-5H-furan-2-one) and 1f (3,4-dibromo-5-methoxycarbonyloxy-5H-furan-2-one) and mucochloric acid acetate 1h (3,4-dichloro-5-acetoxy-5H-furan-2-one) was achieved to afford gamma-functionalized alpha,beta-unsaturated gamma-butyrolactones in good to excellent yield. [reaction: see text]
Assessment of Joint Parameters in a Kinect Sensor Based Rehabilitation Game (2019)

Abstract A Kinect sensor based basketball game is developed for delivering post-stroke exercises in association with a newly developed elbow exoskeleton. Few interesting features such as audio-visual feedback and scoring have been added to the game platform to enhance patient’s engagement during exercises. After playing the game, the performance score has been calculated based on their reachable points and reaching time to measure their current health conditions. During exercises, joint parameters are measured using the motion capture technique of Kinect sensor. The measurement accuracy of Kinect sensor is validated by two comparative studies where two healthy subjects were asked to move elbow joint in front of Kinect sensor wearing the developed elbow exoskeleton. In the first study, the joint information collected from Kinect sensor was compared with the exoskeleton based sensor. In the next study, the length of upperarm and forearm measured by Kinect were compared with the standard anthropometric data. The measurement errors between Kinect and exoskeleton are turned out to be in the acceptable range; 1% for subject 1 and 0.44% for subject 2 in case of joint angle; 5.55% and 3.58% for subject 1 and subject 2 respectively in case of joint torque. The average errors of Kinect measurement as compared to the anthropometric data of the two subjects are 16.52% for upperarm length and 9.87% for forearm length. It shows that Kinect sensor can measure the activity of joint movement with a minimum margin of error.
Possible roles of phosphoenolpyruvate carboxylase and pyruvate kinase in assimilate partitioning in developing maize embryos. (2009)

During their development, seed tissues convert the nutrients coming from the mother plant into proteins, lipids, starch and energy. Thus, they must regulate carefully the use of the available carbon. When isolated developing maize embryos were incubated in a diluted medium without abscisic acid, their lipid synthesis rate was strongly reduced; this metabolic change was accompanied by a small but significant change in the affinity of phosphoenolpyruvate carboxylase for phosphoenolpyruvate, with no changes in the extractable pyruvate kinase activity. The antibiotic phosphomycin was found to activate phosphoenolpyruvate carboxylase and to inhibit pyruvate kinase in extracts from immature embryos. When the isolated maize embryos were incubated in the presence of phosphomycin, the relative incorporation of [14C]-acetate into proteins increased while that into lipids was reduced. These results suggest a central role for phosphoenolpyruvate metabolism in carbon partitioning during the development of maize embryos.
Hydrogen corrosion considerations of carbide fuels for nuclear thermal propulsion applications (1994)

At reactor operation conditions of interest for nuclear thermal propulsion (NTP), graphiteand carbidebased fuel materials have been known to exhibit a number of life-limiting phenomena. These include the formation of liquid, loss by vaporization, creep and corresponding gas flow restrictions, local corrosion, and structure degradation due to excessive mechanical and/or thermal loading. In addition, the irradiation environment can cause a substantial change in the local physical material properties, which can produce high thermal stresses and corresponding stress fracture (cracking). Time-temperature history and cyclic operation of the nuclear reactor can accelerate some of these processes. Based on results of a review of open literature, available in the U.S., a number of major competing interrelated physical mechanisms were identified that affect hydrogen corrosion of carbide fuel materials. This article identifies and discusses in detail these mechanisms associated with the corrosion of carbide-based materials when exposed to hot hydrogen flow at conditions typical of NTP reactors. From the understanding of this complex phenomena, modeling requirements are then identified and discussed.
Ultrasound enhanced plasma surface modification at atmospheric pressure (2012)

Efficiency of atmospheric pressure plasma treatment can be highly enhanced by simultaneous high power ultrasonic irradiation onto the treating surface. It is because ultrasonic waves with a sound pressure level (SPL) above ∼140 dB can reduce the thickness of a boundary gas layer between the plasma and the material surface, and thus, many reactive species generated in the plasma can reach the surface before they are inactivated and can be efficiently utilised for surface modification. In the present work, glass fibre reinforced polyester plates were treated using a dielectric barrier discharge and a gliding arc at atmospheric pressure to study adhesion improvement. The effect of ultrasonic irradiation with the frequency diapason between 20 and 40 kHz at the SPL of ∼150 dB was investigated. After the plasma treatment without ultrasonic irradiation, the wettability was significantly improved. The ultrasonic irradiation during the plasma treatment consistently enhanced the treatment efficiency. The principal effect of ultrasonic irradiation can be attributed to enhancing surface oxidation during plasma treatment. In addition, ultrasonic irradiation can suppress arcing, and the uniformity of the treatment can be improved.
On the integration of memristors with CMOS using nanoimprint lithography (2009)

Memristors were vertically integrated with CMOS circuits using nanoimprint lithography (NIL), making a transistor/memeristor hybrid circuit. Several planarization technologies were developed for the CMOS substrates to meet the surface planarity requirement for NIL. Accordingly, different integration schemes were developed and optimized. UV-curable NIL (UV-NIL) using a double layer spin-on resists was carried out to pattern the electrodes for memristors. This is the first demonstration of NIL on active CMOS substrates that are fabricated in a CMOS fab. Our work demonstrates that NIL is compatible with commercial IC fabrication process. It was also demonstrated that the memristors are integratable with traditional CMOS to make hybrid circuits without changing the current infrastructure in IC industry.
Novel RNA recognition motif domain in the cytoplasmic polyadenylation element binding protein 3 (2014)

The family of cytoplasmic polyadenylation element binding proteins CPEB1, CPEB2, CPEB3, and CPEB4 binds to the 3'-untranslated region (3'-UTR) of mRNA, and plays significant roles in mRNA metabolism and translation regulation. They have a common domain organization, involving two consecutive RNA recognition motif (RRM) domains followed by a zinc finger domain in the C-terminal region. We solved the solution structure of the first RRM domain (RRM1) of human CPEB3, which revealed that CPEB3 RRM1 exhibits structural features distinct from those of the canonical RRM domain. Our structural data provide important information about the RNA binding ability of CPEB3 RRM1.
The future of quantum computing with superconducting qubits (2022)

For the first time in history, we are seeing a branching point in computing paradigms with the emergence of quantum processing units (QPUs). Extracting the full potential of computation and realizing quantum algorithms with a super-polynomial speedup will most likely require major advances in quantum error correction technology. Meanwhile, achieving a computational advantage in the near term may be possible by combining multiple QPUs through circuit knitting techniques, improving the quality of solutions through error suppression and mitigation, and focusing on heuristic versions of quantum algorithms with asymptotic speedups. For this to happen, the performance of quantum computing hardware needs to improve and software needs to seamlessly integrate quantum and classical processors together to form a new architecture that we are calling quantum-centric supercomputing. In the long term, we see hardware that exploits qubit connectivity in higher than 2D topologies to realize more efficient quantum error correcting codes, modular architectures for scaling QPUs and parallelizing workloads, and software that evolves to make the intricacies of the technology invisible to the users and realize the goal of ubiquitous, frictionless quantum computing.
Automated flexure testing of axially rotated optical fiber gratings (2002)

The design and performance of an automated system for flexure testing of optical fiber gratings is described. In addition to flexing (bending) a fiber grating through a specified curvature range, the system can change the axial rotational orientation of the grating relative to the plane of curvature. Flexure is accomplished by holding the grating against a smooth plastic platform. A linear stage deflects the center of the pinned platform to create a curved surface. Two small weights, hanging on the optical fiber, hold the fiber grating against the curved platform and provide constant tension on the optical fiber over the entire range of curvatures. The fiber grating is axially rotated to a different orientation by returning the platform to zero curvature, removing the weights from the optical fiber, and rotating the optical fiber about its axis using a pair of rotation stages. After replacing the weights on the optical fiber, flexure testing resumes at the new axial rotational orientation. The grating transmission spectrum during flexure is monitored with a broadband source and optical spectrum analyzer. All of these steps are done in an automated fashion (unattended) under computer program control. The testing system allows complete characterization of the fiber grating response for curvatures from 0 to 4 m−1 and for axial rotational orientations from 0° to 360°. Use of this automated test fixture eliminates the need for human intervention during the measurements and greatly decreases the testing time while still allowing complete characterization of the flexure response with axial rotational orientation as a parameter. Additional advantages of the testing system include an absolute zero curvature starting position, an absence of hysteresis effects, and accurate frictionless rotation.
DIFS: a distributed index for features in sensor networks (2003)

Sensor networks pose new challenges in the collection and distribution of data. Much attention has been focused on standing queries that use in-network aggregation of time series data to return data statistics in a communication-efficient manner. In this work, rather than consider searches over time series data, we consider searches over semantically rich high-level events, and present the design, analysis, and numerical simulations of a spatially distributed index that provides for efficient index construction and range searches. The scheme provides load balanced communication over index nodes by using the governing property that the wider the spatial extent known to an index node, the more constrained is the value range covered by that node.
Polyethylenimine-Dermatan Sulfate Complex, a Bioactive Biomaterial with Unique Toxicity to CD146-Positive Cancer Cells (2017)

We report unique bioactivity of a polycation-polyanion complex with potential utility for cancer therapy. A complex of disulfide-crosslinked polyethyleneimine (CLPEI), a polycation used for gene complexation, and dermatan sulfate (DS), an anionic polysaccharide to shield excessive cationic charge of the former, has toxicity to a specific group of cancer cell lines, including B16-F10 murine melanoma, A375SM human melanoma, and PC-3 human prostate cancer cells. These CLPEI-DS-sensitive cells express CD146, which binds to the complex via interaction with DS. There is a positive correlation between toxicity and intracellular level of CLPEI, indicating that the CLPEI-DS-sensitivity is attributable to the increased cellular uptake of CLPEI mediated by the DS-CD146 interactions. <i>In vitro</i> studies show that CLPEI-DS complex causes G<sub>0</sub>/G<sub>1</sub> phase arrest and apoptotic cell death. In syngeneic and allograft models of B16-F10 melanoma, CLPEI-DS complex administered with a sub-toxic level of doxorubicin potentiates the chemotherapeutic effect of the drug by loosening tumor tissues. Given the unique toxicity, CLPEI-DS complex may be a useful carrier of gene or chemotherapeutics for the therapy of CD146-positive cancers.
Intrinsic functional connectivity of the brain swallowing network during subliminal esophageal acid stimulation (2013)

The FC of BSN is amenable to modulation by sensory input. The modulatory effect of sensory pharyngoesophageal stimulation on BSN is mainly mediated through changes in the FC of the insula. The alteration induced by subliminal visceral esophageal acid stimulation is in different insular connections compared with that of conscious somatic pharyngeal stimulation.
Vascular metabolic dissipation in Murray's law (2006)

The metabolic dissipation in Murray's minimum energy hypothesis includes only the blood metabolism. The metabolic dissipation of the vascular tree, however, should also include the metabolism of passive and active components of the vessel wall. In this study, we extend the metabolic dissipation to include blood metabolism, as well as passive and active components of the vessel wall. The analysis is extended to the entire vascular arterial tree rather than a single vessel as in Murray's formulation. The calculations are based on experimentally measured morphological data of coronary artery network and the longitudinal distribution of blood pressure along the tree. Whereas the model includes multiple dissipation sources, the total metabolic consumption of a complex vascular tree is found to remain approximately proportional to the cumulative arterial volume of the unit. This implies that the previously described scaling relations for the various morphological features (volume, length, diameter, and flow) remain unchanged under the generalized condition of metabolic requirements of blood and blood vessel wall.
On the capacity of a multiple-antenna communication link with channel side information (2003)

We investigate the capacity of a system with multiple transmit and receive antennas, assuming that the transmitter and receiver both have access to (possibly defective) channel-state information. Two different special cases of a general system are studied in detail. Our main results are capacity expressions for these cases and a general conclusion that the encoder can be split into separate "space-time coding" and "direction weighting" or "beamforming," without capacity loss. We also present numerical results illustrating the dependence of capacity on the parameters of a quantization scheme providing channel-state information to the transmitter from the receiver. These results have high practical value since the assumptions behind them are closely related to the ones of the closed-loop mode in the UMTS/WCDMA standard.
Transcription Coupled DNA Methylation Mediated by RNA Pol II and DNMT1 (2014)

Transcriptional gene silencing is mediated by various epigenetic modifications including DNA methylation, histone modifications and recruitment of binding proteins that reads the methyl and other modification marks. The order in which these modifications occur followed by repressor protein recruitment remains contentious. Here, using purified protein components, we show that mammalian RNA polymerase II (RNA Pol II) is involved in DNA methylation control. DNA (cytosine-5) methyltransferase 1 (DNMT1) colocalizes, directly interacts and binds to the phosphorylated C-terminal repeat domain (CTD) of Rpb1, a major structural subunit of RNA Pol II. The association of RNA Pol II with DNMT1 during transcription enhances DNA methylation, and methylated DNA doesn’t affect in vitro transcription. Addition of methyl CpG binding protein 2 (MeCP2), inhibited in vitro transcription of DNA in a methylation dependent manner, suggesting a possible mechanism for RNA Pol II coupled transcriptional silencing mediated by DNMT1 and MeCP2.
Short-wavelength lasers (1992)

The development of short-wavelength lasers is reviewed. Three pumping mechanisms have been demonstrated which produce lasing at wavelengths from 3 to 100 nm. These mechanisms include electron-collisional excitation, electron-ion recombination, and photo-excitation. Examples of X-ray lasers and future directions of the field are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A hybrid control scheme for a copier paperpath (1999)

Presents a hybrid control approach for a copier paperpath. The paperpath transports sheets from the feeder to the image transfer section. At arrival time, every sheet must synchronize with its image on the photoreceptor belt. A non-cooperative hybrid control scheme that controls intersheet spacings is proposed. The controller switches between different modes to satisfy all the system constraints. Cooperation, which enhances performance, is then introduced for a simplified system model, based on the notion of controllable regions. Simulations illustrate both strategies.
The jPET-D4: Simple and Reliable Construction Method for 4-Layer DOI Crystal Blocks (2006)

The final design of the 4-layer DOI detector module for jPET-D4 system was determined and we produced 120 of the DOI crystal blocks. The jPET-D4 detector module consists of four layers of 16 by 16 Gd <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2 </sub> SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> (GSO) crystals and a 256 channel flat panel position sensitive photomultiplier tube (256ch FP-PMT). Two kinds of GSO crystals that show different scintillation decay time constants are used in the upper and lower two layers in order to distinguish these layers using pulse shape discrimination. Proper reflector insertion in the crystal block enables to identify crystals of detection in each two layers. For mass production of the DOI crystal block composed of 1024 crystal elements with the proper reflector arrangement, we used appropriate tools which promote simple construction as well as uniform configuration. The construction took only 3 hours per one crystal block. The produced 120 DOI crystal blocks were estimated their characteristics; pulse shape discrimination, energy resolution and full energy peak. The results show that misidentification in each GSO layer is less than 5% on pulse shape discrimination, the average of energy resolutions for the central four crystals of the 1st (farthest from PMT), 2nd, 3rd and 4th-layer are 15.7 plusmn 1.0%, 15.8 plusmn 0.6%, 17.7 plusmn 1.2% and 17.3 plusmn 1.4%, respectively and full energy peak variation among four layers is less than 5% in average