gebhart/patrepeval huggingface dataset:
Dizygotic Twinning Is Not Linked to Variation at the α -Inhibin Locus on Human Chromosome 2* (2000)

Natural multiple pregnancy in women leading to dizygotic (DZ) twins is familial and varies across racial groups, suggesting a genetic predisposition. Mothers of DZ twins have a higher incidence of spontaneous multiple ovulation and elevated FSH concentrations. FSH release is controlled by feedback of inhibin peptides from the ovary, and immunization against inhibin alpha-subunit results in an increased ovulation rate in animals. The inhibin alpha-subunit is therefore a candidate gene for mutations that may increase the frequency of DZ twinning. Restriction digests of a PCR product from exon 1 with the enzyme SpeI detects a C/T polymorphism at bp 128 with two alleles of 447 and 323/124 bp. The polymorphism was typed in 1,125 individuals from 326 pedigrees with 717 mothers of spontaneous DZ twins. The alpha-inhibin locus mapped within 3 centimorgans of D2S164, and linkage with DZ twinning was excluded [decimal log odds ratio (LOD) score, -2.81 at theta = 0]. There was complete exclusion of linkage (LOD, less than -2) of a gene conferring relative risk 1.8 (lambdas, >1.8) across the chromosome, except at the p-terminus region and a small peak (maximum LOD score, 0.6) in the region of D2S151-D2S326. Analysis using either recessive or dominant models excluded linkage with DZ twinning in this population (LOD score, less than -2.5) across chromosome 2. We conclude that dizygotic twinning is not linked to variation in the alpha-inhibin locus. The results also suggest that mutations in other candidates on chromosome 2, including the receptor for FSH and the betaB-inhibin subunit (INHBB) cannot be major contributors to risk for DZ twinning.
Control of Ionic Interactions in Silver Salt−Polymer Complexes with Ionic Liquids:  Implications for Facilitated Olefin Transport (2006)

The ionic liquids 1-butyl-3-methyl imidazolium BMIM+NO3- and BMIM+BF4- have been successfully utilized to increase the activity in reversible π-complexation with olefins of silver cations in silver polymer electrolytes consisting of AgNO3 dissolved in poly(2-ethyl-2-oxazoline) (POZ). In the absence of the ionic liquids, AgNO3 is not readily dissolved in POZ and is instead because of its high lattice energy present mostly as chemically less active ion pairs or higher order aggregates. The activation of Ag+ in silver polymer electrolytes in the presence of these ionic liquids is principally due to the reduction of the interactions between Ag+ and NO3- produced by the interaction between BMIM+ and NO3-, and this effect does not occur in the presence of common salts such as NaNO3. We investigated these systems with FT-IR, FT-Raman, and XPS and calculated the theoretical electronic structures of the relevant species. The increased activity in these membranes of Ag+ in reversible π-complexation with olefins was further confirmed by evaluating the sorption and desorption behavior of propylene and the performances of the membranes in the separation of olefin/paraffin mixtures.
Demo Abstract: BE-Mesh: Bluetooth Low Energy Mesh Networking (2019)

We propose and discuss BE-Mesh-Bluetooth low Energy-Meshed network, a new paradigm for BLE (Bluetooth Low Energy) that enables mesh networking among wirelessly interconnected devices, both in a single hop and multi-hop fashion. Starting from the classical Master/Slave paradigm of Bluetooth, we build two new layers based on BLE stack that allow the final user to set-up, in a fast way, the desired network topology while hiding the complexity and low-level details of the BLE stack. We also prototype, as a proof of concept, an open source Android library [1] that implements our communication paradigm and an Android application that allows the exchange of text messages across the mesh network. Last, we demonstrate how BE-Mesh enables Internet access sharing with the whole mesh from a single Internet-connected device.
A cryogenic solid-state reaction at the interface between Ti and the Bi2Se3 topological insulator (2020)

Titanium deposited on the Bi<sub>2</sub>Se<sub>3</sub> surface reacts (even at 130 K) and forms new phases.
Corrigendum: Radical trans‐Hydroboration of Alkynes with N‐Heterocyclic Carbene Boranes (2020)

In the reference section of this Communication, reference [2] contains incorrect information. The correct reference is shown below.
Measurement of isolated-photon pair production in pp collisions at $ \sqrt{s}=7\;TeV $ with the ATLAS detector (2013)

A bstract The ATLAS experiment at the LHC has measured the production cross section of events with two isolated photons in the final state, in proton-proton collisions at $ \sqrt{s}=7\;\mathrm{TeV} $ . The full data set collected in 2011, corresponding to an integrated luminosity of 4 . 9 fb −1 , is used. The amount of background, from hadronic jets and isolated electrons, is estimated with data-driven techniques and subtracted. The total cross section, for two isolated photons with transverse energies above 25 GeV and 22 GeV respectively, in the acceptance of the electromagnetic calorimeter (| η | &lt; 1 . 37 and 1 . 52 &lt; | η | &lt; 2 . 37) and with an angular separation Δ R &gt; 0 . 4, is $ 44.0_{-4.2}^{+3.2 } $ pb. The differential cross sections as a function of the di-photon invariant mass, transverse momentum, azimuthal separation, and cosine of the polar angle of the largest transverse energy photon in the Collins-Soper di-photon rest frame are also measured. The results are compared to the prediction of leading-order parton-shower and next-to-leading-order and next-to-next-to-leading-order parton-level generators.
Inhibition of RNA Synthesis in vitro by Acridines - Relation between Structure and Activity (1998)

The effects of acridine derivatives (proflavine and 2,7-dialkyl derivatives, diacridines and triacridines, 9-aminoacridine carboxamides, and 9-anilinoacridine, amsacrine and its congeners) on overall RNA synthesis in vitro, on synthesis of initiating oligonucleotides and the binding of the enzyme to DNA were studied. The primary mechanism of action is related to inhibition of the enzyme binding to DNA. The acridines (intercalating or non-intercalating and bis-intercalating ligands) assayed here differ in the properties of their complexes with DNA. Correlation is generally observed between inhibition of RNA synthesis in vitro and cytotoxicity in cell cultures for di- and triacridines and 9-aminoacridine carboxamide derivatives. No relationship was found between the effect on RNA polymerase system and biological effects for amsacrine and its derivatives in contrast to the other series of acridines studied here. The aniline ring seems to decrease the inhibitory potency of a ligand. The discrepancy between the biological effect and RNA synthesis inhibition may be due to a different mechanism of cytotoxicity action of amsacrine which is a potent topoisomerase II poison.
Variable Dielectrics in the Calcium Magnesium Titanate System Characterized with Scanning Microwave Microscopy (2006)

Near‐field scanning microwave microscopy (SMM) is used to observe the fine‐scale dielectric phenomena. The purpose of the present study is to apply the SMM to examine the dielectrics in the multiphase CT–MT–M 2 T system and study the dielectric relative permittivity distribution. SMM clearly resolves the three‐phase distribution and is in agreement with chemical analysis.
125-km Long Cavity Based on Self-Seeded RSOAs Colorless Sources for 2.5-Gb/s DWDM Networks (2014)

The laser behavior of reflective semiconductor optical amplifier self-seeded sources is investigated. 2.5-Gb/s transmission is realized with optical cavities of 10, 26, 100, and 125 km for access and metropolitan networks, realizing the longest amplified self-seeded external cavity laser. Moreover, Gigabit Ethernet, common public radio interface, and 2.5-Gb/s transmissions are experimented using amplified self-seeded reflective semiconductor optical amplifier wavelength division multiplexing passive optical networks systems. A field trial setup is exploited to test the system performance in terms of reach and optical budget.
Phase 1 Exploratory Efficacy of the Novel Enzyme Replacement Therapy NeoGAA in Treatment-Naïve and Alglucosidase Alfa-Treated Late-Onset Pompe Disease Patients (I4.011) (2016)

OBJECTIVE: This open-label, ascending-dose study (NCT01898364) evaluated safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and exploratory efficacy of the second-generation enzyme replacement therapy neoGAA in 10 treatment-naïve and 14 alglucosidase alfa-experienced (≥9 mo of treatment) patients with late-onset Pompe disease. BACKGROUND: Exploratory efficacy results are presented here; safety profile and pharmacokinetics are reported separately. DESIGN/METHODS: Adult patients who could walk ≥50 m independently and had upright FVC ≥50[percnt] predicted at baseline received IV neoGAA (5, 10, or 20mg/kg qow) for 24 wks. RESULTS: Study completers included 9 treatment-naïve patients (5mg/kg, n=3; 10mg/kg, n=3; 20mg/kg, n=3) and 12 treatment-experienced patients (5mg/kg, n=3; 10mg/kg, n=4; 20mg/kg, n=5). NeoGAA was well-tolerated in both groups. Quadriceps muscle biopsy glycogen levels were low (~6[percnt]) in most patients in both groups at baseline, and remained mostly unchanged. Naïve patients’ percent predicted sitting-FVC remained stable or increased from baseline to Week 25 (mean±SD changes: 5mg/kg, −2.7±8.8[percnt], n=4; 10mg/kg, +4.3±4.9[percnt], n=3; 20mg/kg, +6.2±3.2[percnt], n=3), while MEP and MIP [percnt] predicted improved or remained stable (respective mean ± SD changes: 5mg/kg,+8.1±2.8[percnt], n=2, +6.1±0.79[percnt], n=2; 10mg/kg, 16.5±8.0[percnt], n=3, 10.6±4.9[percnt], n=3;20mg/kg, 12.0±4.1[percnt], n=3; 7.9 ±15.7[percnt], n=3). In treatment-experienced patients, [percnt] predicted sitting-FVC remained stable from baseline to week 25 (5mg/kg, −0.5±4.3[percnt], n=4; 10mg/kg, −2.0±2.2[percnt], n=4; 20mg/kg, +1.4±5.7[percnt], n=5), as did [percnt] predicted MEP and MIP (5mg/kg, −3.5±10.8[percnt], n=4, +10.5±7.3[percnt], n=4; 10 g/kg, +15.7±38.4[percnt], n=3, +4.2±12.6[percnt], n=3; 20mg/kg, +6.0±21.8[percnt], n=5; −0.2±6.9[percnt], n=5). Six minute walk test distances were generally stable or increased with neoGAA without relationship to patient group or dose level. QMFT and HHD scores improved in both groups, irrespective of dose, whereas GSGC and GMFM-88 showed minimal changes across groups and all dose levels. CONCLUSIONS: While the efficacy assessments were exploratory, these results support further development of neoGAA. Study Supported by: Genzyme, a Sanofi Company
Nucleotides and Nucleic Acids: Mononucleotides (2010)

This report covers the literature relating to mono- and dinucleotides that were published between January 2008 and January 2009. One particular area, which will potentially have a major impact on future nucleotide research, is the newly acquired accessibility to stereoregular oligodeoxyribonucleosid...
Six Sigma Methodology Can Be Used to Improve Adherence for Antibiotic Prophylaxis In Patients Undergoing Noncardiac Surgery (2006)

We conclude that Six Sigma methods were used to successfully improve our process for timing of perioperative antibiotic prophylaxis before surgical incision. An electronic anesthesia record keeping system is a useful tool to monitor this process improvement.
Cover Picture: Fluorous Synthesis of Hydantoin‐, Piperazinedione‐, and Benzodiazepinedione‐Fused Tricyclic and Tetracyclic Ring Systems (Eur. J. Org. Chem. 9/2006) (2006)

Abstract The cover picture shows a range of molecular scaffolds that can be achieved through fluorous enhanced diversity‐oriented synthesis. Construction of the ring skeletons is accomplished by multicomponent reactions followed by post‐condensation modifications. The reactions are accelerated by microwave irradiation, and purifications are facilitated by fluorous separation. This new solution‐phase synthetic technique is presented in the Short Communication by W. Zhang et al. on p. 2055 ff.
Pilot-scale assessment of natural gas reburning technology for NO sub x reduction from MSW (municipal solid waste) combustion systems (1989)

A program is under way to evaluate the use of natural gas as an NO{sub x} control technique for municipal solid waste (MSW) combustion systems. The program is funded jointly by the Institute of Gas Technology (IGT) Sustaining Membership Program (SMP), the Gas Research Institute (GRI), and Riley Stoker Corporation (Riley) and is a cooperative development effort between IGT, Riley, and Takuma Company, Ltd. (Takuma). The program entails assessment of applicable NO{sub x} control technologies and acquisition of baseline data from a modern existing MSW mass burn facility, followed by pilot-scale development of the selected NO{sub x} control techniques and preparation of design specifications for field verification of this technology. This paper concentrates on the results of the pilot-scale developmental efforts. 6 refs., 13 figs., 5 tabs.
ChemInform Abstract: SO2 Extrusion in 1,2,6‐Thiadiazine 1,1‐Dioxides: A Novel Synthesis of Pyrazoles. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Gelatin-derived bioadhesives for closing skin wounds: An in vivo study (1999)

Bioadhesives have been used in surgery as hemostatic and wound healing agents. GRF (gelatin + resorcinol + formaldehyde) glue, composed of a mixture of gelatin and resorcinol polymerized by the addition of formaldehyde, has been used for this purpose. Widespread acceptance of the GRF glue, however, has been limited by reports of cytotoxicity due to its release of formaldehyde upon degradation. It has been suggested by Wertzel et al. that the cytotoxicity problem of GRF glue may be overcome by changing its cross-linking method. The study was, therefore, undertaken to assess the feasibility of using a water-soluble carbodiimide or genipin to cross-link gelatin as new bioadhesives to close skin wound lesions in a rat model. Formaldehyde-cross-linked counterpart (GRF glue) and a resorbable suture were used as controls. It was noted that the tensile strength of the skin across each wound treated by either application of test glues or suture increased consistently with time during the healing process. Also, the wounds repaired by test glues or suture caused no calcification. The suture used in the study was completely resorbed at the wound area in about 6 days postoperatively. However, the durations required to completely resorb the carbodiimide- or genipin-cross-linked glues were approximately the same (9 days), while it took about 14 days to completely resorb the formaldehyde-cross-linked glue. The healing process for the suture wound repaired was more rapid than those treated by test glues. Of the test glues, the wounds treated by the carbodiimide- or genipin-cross-linked glues induced less inflammatory response and recovered sooner than that treated by the formaldehyde-cross-linked glue. This indicated that the biocompatibility of the carbodiimide- or genipin-cross-linked glues was superior to the formaldehyde-cross-linked glue. The results of this study may serve as a preliminary experimental model for the further investigation of both the carbodiimide- and genipin-cross-linked glues when applied to human skin closure.
Group LARS-Based Iterative Reweighted Least Squares Methodology for Efficient Statistical Modeling of Memory Designs (2022)

Regularized logistic regression is a popular classification tool that can be employed to accurately model the binary nature of the memory cell fail mechanisms for purposes of the yield analysis of memory designs. The iterative reweighted least squares (IRLS) method has been employed along with the least angle regression (LARS) to efficiently solve the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$L_{1}$ </tex-math></inline-formula> regularized logistic regression problem. In this brief, we propose an efficient <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$L_{1}$ </tex-math></inline-formula> regularized logistic regression methodology. At the core lies a Group LARS-based approach that benefits from Group LARS inherent ability to handle groups of variables and exploits the natural evolution of the solution to speed up the search for the critical features of the classifier. Thus, it tracks Newton’s step direction from one round of the solution to the next and employs weighted directions to efficiently solve for the underlying <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$L_{1}$ </tex-math></inline-formula> constrained iterative least squares problem. We apply the methodology in the context of an importance sampling-based yield analysis framework targeting rare fail probability estimation. We study the yield of 14-nm FinFET SRAM designs with programmable and resonant boosting. Our results demonstrate up to <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$14\times $ </tex-math></inline-formula> – <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$20\times $ </tex-math></inline-formula> speedup for the Group LARS compared to the pure LARS-based approach, and we report 98.7% accuracy and 0.12 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\sigma $ </tex-math></inline-formula> average error compared to pure circuit-simulations approach for the resulting classifier.
Multiscale modelling of recrystallization and grain growth phenomena in hot forming conditions (2015)

International audience
Homeostatic Control of Synaptic Activity by Endogenous Adenosine is Mediated by Adenosine Kinase (2012)

Extracellular adenosine, a key regulator of neuronal excitability, is metabolized by astrocyte-based enzyme adenosine kinase (ADK). We hypothesized that ADK might be an upstream regulator of adenosine-based homeostatic brain functions by simultaneously affecting several downstream pathways. We therefore studied the relationship between ADK expression, levels of extracellular adenosine, synaptic transmission, intrinsic excitability, and brain-derived neurotrophic factor (BDNF)-dependent synaptic actions in transgenic mice underexpressing or overexpressing ADK. We demonstrate that ADK: 1) Critically influences the basal tone of adenosine, evaluated by microelectrode adenosine biosensors, and its release following stimulation; 2) determines the degree of tonic adenosine-dependent synaptic inhibition, which correlates with differential plasticity at hippocampal synapses with low release probability; 3) modulates the age-dependent effects of BDNF on hippocampal synaptic transmission, an action dependent upon co-activation of adenosine A2A receptors; and 4) influences GABAA receptor-mediated currents in CA3 pyramidal neurons. We conclude that ADK provides important upstream regulation of adenosine-based homeostatic function of the brain and that this mechanism is necessary and permissive to synaptic actions of adenosine acting on multiple pathways. These mechanistic studies support previous therapeutic studies and implicate ADK as a promising therapeutic target for upstream control of multiple neuronal signaling pathways crucial for a variety of neurological disorders.
A Survey of the Anther Culture Response of Brassica oleracea L. Cultivars Grown Under Field Conditions (1990)

Abstract Anther culture studies were conducted on a wide variety of different vegetable Brassica oleracea L. cultivars grown under field conditions. Representative selections were included from different varieties including: broccoli , var. italica; heading broccoli, var. botrytis; Brussels sprouts, var. gemnifera; Chinese Kale, var. alboglabra; Kales, vars. acephala, medullosa, ramosa, selensia; cauliflower, var. botrytis; kohlrabi, var. gongylodes; and cabbage, vars. capitata and sabanda. At least some microspore derived embryos were recovered from the majority of cultivars tested; however, rates of embryo formation were sometimes lower than those obtained under controlled environmental conditions. In general the anther culture response was greatest for cabbage and other vegetables that required vernalization for flowering. Results were lower for materials exposed to high temperature stresses before culture. Nevertheless, it is clear that the use of anther culture procedures in breeding programs is possible without access to extensive controlled environmental facilities.
A 50V high-speed level shifter with high dv/dt immunity for multi-MHz DCDC converters (2014)

Size and cost of a switched mode power supply can be reduced by increasing the switching frequency. The maximum switching frequency and the maximum input voltage range, respectively, is limited by the minimum propagated on-time pulse, which is mainly determined by the level shifter speed. At switching frequencies above 10 MHz, a voltage conversion with an input voltage range up to 50 V and output voltages below 5 V requires an on-time of a pulse width modulated signal of less than 5 ns. This cannot be achieved with conventional level shifters. This paper presents a level shifter circuit, which controls an NMOS power FET on a high-voltage domain up to 50 V. The level shifter was implemented as part of a DCDC converter in a 180 nm BiCMOS technology. Experimental results confirm a propagation delay of 5 ns and on-time pulses of less than 3 ns. An overlapping clamping structure with low parasitic capacitances in combination with a high-speed comparator makes the level shifter also very robust against large coupling currents during high-side transitions as fast as 20 V/ns, verified by measurements. Due to the high dv/dt, capacitive coupling currents can be two orders of magnitude larger than the actual signal current. Depending on the conversion ratio, the presented level shifter enables an increase of the switching frequency for multi-MHz converters towards 100 MHz. It supports high input voltages up to 50 V and it can be applied also to other high-speed applications.
Robust tracking servo system considering force disturbance for the optical disk recording system (2006)

This paper proposes a new robust tracking servo system for the optical disk recording system with feedforward controller based on the prediction of the tracking error. In optical recording systems, the feedback servo system must suppress the influence of force disturbance and parameter variation. To overcome this problem, this paper designs the robust feedback control system by using coprime factorization and disturbance observer. The detecting signal of the optical disk recording system is only a tracking error. Hence, the feedforward controller of the proposed tracking control system is constructed based on both the "zero-phase-error tracking" control theory and the prediction of the tracking error. The experimental results point out that the proposed tracking servo system has a quick and precise tracking response and keeps the residual tracking error below its tolerance.
Isolation of Helicobacter Pylori From Vomitus in Children and Its Implication in Gastro-Oral Transmission (1999)

This is the first study reporting successful isolation of H. pylori from naturally produced vomitus. The result implies that transmission of H. pylori infection by vomitus, especially in children, is possible.