gebhart/patrepeval huggingface dataset:
Verlauf eines Icterus gravis (Hepatitis epidemica) bei einer milzlosen Kranken mit chronischer essentieller Thrombopenie (1954)

Mann und Magath, von Rosenthai und Mitarbeitern bestätigt, haben dargetan, daß es beim Tier auch ohne Leber zu einem Icterus kommen kann, — unser Fall zeigt den Verlauf einer schweren Hepatitis ohne Milz: Die Milzexstirpation (Prof. Dr. ) mußte bei der 45jährigen Kranken im Mai 1953 vorgenommen werden, da sich unter dem Bilde einer schweren hämorrhagischen Diathese eine Anämie von 6,6 g = 41% OHb und 2464000 Roten entwickelt hatte, welche mit allen konservativen Mitteln einschließlich ACTH und Bluttransfusionen nicht zu beherrschen war. Die Diagnose chronische essentielle Thrombopenie war gesichert durch die typische Anamnese, Nasen- und Genitalblutungen, der Haut, verlängerte Blutungszeit (13 Min. 20 Sek.) bei fast normaler Gerinnungszeit (5 Min. 10 Sek.), fehlender Retraktion des Blutkuchens. Thrombocytenzahlen 14000 bis 50000. Megakaryocytenvermehrung im Sternalmark (Abb. 1).
Llama-Derived Single Domain Antibodies Specific for Abrus Agglutinin (2011)

Llama derived single domain antibodies (sdAb), the recombinantly expressed variable heavy domains from the unique heavy-chain only antibodies of camelids, were isolated from a library derived from llamas immunized with a commercial abrin toxoid preparation. Abrin is a potent toxin similar to ricin in structure, sequence and mechanism of action. The selected sdAb were evaluated for their ability to bind to commercial abrin as well as abrax (a recombinant abrin A-chain), purified abrin fractions, Abrus agglutinin (a protein related to abrin but with lower toxicity), ricin, and unrelated proteins. Isolated sdAb were also evaluated for their ability to refold after heat denaturation and ability to be used in sandwich assays as both capture and reporter elements. The best binders were specific for the Abrus agglutinin, showing minimal binding to purified abrin fractions or unrelated proteins. These binders had sub nM affinities and regained most of their secondary structure after heating to 95 °C. They functioned well in sandwich assays. Through gel analysis and the behavior of anti-abrin monoclonal antibodies, we determined that the commercial toxoid preparation used for the original immunizations contained a high percentage of Abrus agglutinin, explaining the selection of Abrus agglutinin binders. Used in conjunction with anti-abrin monoclonal and polyclonal antibodies, these reagents can fill a role to discriminate between the highly toxic abrin and the related, but much less toxic, Abrus agglutinin and distinguish between different crude preparations.
Synthesis of a new potent α-fucosidase inhibitor (1996)

A. Hansen, T. M. Tagmose and M. Bols, Chem. Commun., 1996, 2649 DOI: 10.1039/CC9960002649
Halogen bonding-based anion coordination in calixarene/inorganic halide/diiodoperfluorocarbon assemblies (2009)

Self-assembly of ternary mixtures composed of cation segregating agent/inorganic halide (penta-tert-butyl-pentakis(ethoxycarbonylmethoxy)calix[5]arene (1)/NaI or 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8,8,8]hexacosane (4)/BaI2) and diiodoperfluorocarbon (1,8-diiodoperfluorooctane (2)) produces crystalline supramolecular salts 3 and 5, respectively, whose structural characteristics in the solid state have been elucidated by single-crystal X-ray analyses. Encapsulation of alkali or alkaline-earth metal ions inside the complexing pocket of the appropriate receptor generates naked iodide anions, which effectively drive the self-assembly of diiodoperfluorooctane 2 into halogen-bonded supramolecular anions with a comb-like copolymer structure.
Broadcasting Sequential Processes (BSP) (1984)

Communication in a broadcast protocol multiprocessor (BPM) is inherently different from that in distributed systems formed by explicit links between processors. A message broadcast by a processor in a BPM is received directly by all other processors in the network instead of being restricted to only one processor. Broadcasting is an inexpensive way of communicating with a large number of processors on a BPM. In this paper I will describe a new approach to user-level distributed programming called broadcast programming, i.e., distributed programs written as cooperating broadcasting sequential processes (BSP). Existing concurrent programming languages do not provide facilities to exploit the broadcast capability of a BPM. The idea of distributed programs written as BSP is tailored to exploiting a BPM architecture but is not restricted to such an architecture-however, implementation of the broadcast capability may not be as efficient on other architectures. I will illustrate the utility and convenience of broadcast programming with many examples. These examples will also be used to explore the suitability and advantages of BSP and to determine appropriate facilities for BSP.
Application of computational thermodynamic and kinetic models to laser surface alloying (2005)

Surface physical and mechanical properties can be tailored to different needs by the laser surface alloying process. These property modifications are made by localized melting of substrate material by laser beams with addition of alloying elements as well as hard particles. Through selection of proper hard particles, modification of underlying microstructure through rapid cooling and controlled alloying addition, one can tailor these surfaces for required properties. However, these processes are developed through extensive experimental trial-anderror methodology. This research shows an alternate design methodology by which these processes can be designed through computational thermodynamic and kinetic models.
Ultra-thin tag fabrication and sensing technique using third harmonic for implantable wireless sensors (2011)

This paper presents the fabrication of an ultra-thin tag for identification and sensing applications in extremely small implantable regions. Particularly, we are demonstrating the capability to create a telemetry system which is implantable in a mouse eye. This system will eventually be able to monitor intraocular pressure (IOP). The small size of the mouse eye presents challenges for surgery and the integration of components. Therefore, there is a need for a device which is biocompatible, flexible, compressible, self-expandable, and thin enough for implantation. This paper demonstrates the fabrication of a thin tag with a self-expandable Nitinol antenna, polymer based embedded components, and high density routing. Telemetry with a small tag implanted inside of the eye is established for the first time using the 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> order harmonic response from the implanted device.
High resolution Fabry-Perot displacement interferometry: a bridge between the meter and the farad (2010)

A high resolution Fabry-Perot interferometer system is designed to measure displacement. We achieve a fractional uncertainty of δL/L~1.25×10−9 without any optical frequency standard, and resolve hysteresis in a piezoelectric actuator over 7 nm.
Physiology and Pathophysiology of Digestion, Part 2 (2018)

Abstract This collaboration of two physiologists and a gastroenterologist provides medical and graduate students, medical and surgical residents, and subspecialty fellows a comprehensive summary of...
New Prospects for Time-of-Flight PET With LSO Scintillators (2006)

The growing interest in time-of-flight PET triggered the study of the time resolution obtainable with a 4times4times20 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> LSO crystal coupled directly to the center of a 52 mm in diameter Photonis XP20D0 photomultiplier as well as the time resolution obtainable with the use of an 11 mm thick Lucite light diffuser that simulates the conditions in typical PET block detectors. The LSO crystal directly coupled to the PMT yielded a time resolution of 166plusmn5 ps, while in the case of light readout with the use of the light diffuser it degraded to 196plusmn5 ps and 277plusmn6 ps in the center and at the edge of the PMT, respectively. The light diffuser was coated on the sides with black tape to absorb light and to approximate in this way the realistic performance of a future block detector. Similar time resolution was obtained by coupling the LSO crystal either to the Photonis XP20D0 PMT or to a very fast 25 mm diameter Hamamatsu R5320 PMT. These results illustrate the advantages of the very low time jitter of the Hamamatsu PMT on one side, and high quantum efficiency and a screening grid at the anode of the Photonis PMT, on the other. This study strongly suggests that time-of-flight PET based on LSO crystals is a realistic proposition for the further development
Towards exploratory test instance specific algorithms for high dimensional classification (2005)

In an interactive classification application, a user may find it more valuable to develop a diagnostic decision support method which can reveal significant classification behavior of exemplar records. Such an approach has the additional advantage of being able to optimize the decision process for the individual record in order to design more effective classification methods. In this paper, we propose the Subspace Decision Path method which provides the user with the ability to interactively explore a small number of nodes of a hierarchical decision process so that the most significant classification characteristics for a given test instance are revealed. In addition, the SD-Path method can provide enormous interpretability by constructing views of the data in which the different classes are clearly separated out. Even in cases where the classification behavior of the test instance is ambiguous, the SD-Path method provides a diagnostic understanding of the characteristics which result in this ambiguity. Therefore, this method combines the abilities of the human and the computer in creating an effective diagnostic tool for instance-centered high dimensional classification.
Pharmacoepigenomics in Colorectal Cancer: A Step Forward in Predicting Prognosis and Treatment Response (2008)

Despite therapeutic innovations and increasing education on lifestyle to prevent colorectal cancer, it is still one of the most common cancer types, and for men the second cause of cancer-related death. Lately, much attention has been given to identify molecular markers involved in colorectal cancer prognosis and treatment with the aim to develop a more accurate classification system based on (epi)genetic alterations and, in addition, find markers that could potentially enhance management of colorectal cancer by predicting treatment response in advance. Although many genetic markers have been claimed to have prognostic or predictive influence, results are often inconclusive and, with some exception, they are not used in standard practice. Epigenetic alterations have received less attention although they are probably even more interesting as they can potentially be reversed through drug treatment. This review describes the current knowledge on the prognostic and predictive value of epigenetic markers in colorectal cancer.
The Caenorhabditis elegans ADAMTS Family Gene adt-1 Is Necessary for Morphogenesis of the Male Copulatory Organs (2002)

Remodeling of the extracellular matrix (ECM) is pivotal for various biological processes, including organ morphology and development. The Caenorhabditis elegans male tail has male-specific copulatory organs, the rays and the fan. Ray morphogenesis, which involves a rapid remodeling of the ECM, is an important model of morphogenesis, although its mechanism is poorly understood. ADAMTS (a disintegrin-like and metalloproteinase with thrombospondin type I motifs) is a novel metalloproteinase family that is thought to be an important regulator for ECM remodeling during development and pathological states. We report here that a new C. elegans ADAMTS family gene, adt-1, plays an important regulatory role in ray morphogenesis. Inactivation of the adt-1 gene resulted in morphological changes in the rays as well as the appearance of abnormal protuberances around the rays. In addition, mating ability was remarkably impaired in adt-1 deletion mutant males. Furthermore, we found that the green fluorescent protein reporter driven by the adt-1 promoter was specifically expressed throughout the rays in the male tail. We hypothesize that ADT-1 controls the ray extension process via remodeling of the ECM in the cuticle.
Blood mimicking fluid for high-intensity focused ultrasound applications (2007)

A blood-mimicking fluid (BMF) having viscosity, attenuation, and backscatter similar to that of human blood has been developed for the acoustic and thermal characterization of HIFU ablation devices. The BMF consists of gellan gum, low density polyethelene particles, and nylon particles dispersed in water, glycerin, and alcohol. The BMF was characterized for attenuation coefficient, speed of sound, backscatter coefficient, viscosity, thermal diffusivity, and thermal conductivity. The low attenuation as well as the sound speed and the bloodlike backscatter indicate the usefulness of the BMF for ultrasound imaging and flow applications. These properties, along with thermal conductivity and diffusivity also within the range found in human tissue and the ability to withstand temperature increases above 70&amp;lt;th&amp;gt;°C with no significant change in its properties, make this material appropriate for HIFU applications. This fluid also exhibits viscosity varying as a function of velocity (or shear rate). [This research was supported by the Defense Advanced Research Projects Agency (DARPA) through IAG No. 224-05-6016.]
Non-Coherent and Semi-Coherent Denoise-and-Forward Schemes for Two-Way Relaying (2012)

We investigate non-coherent and semi-coherent schemes for physical-layer network coding in two-way relaying scenarios. We distinguish between scenarios without any channel knowledge requirements (non-coherent communication) and scenarios when either the relay or the users have receive channel knowledge (semi-coherent communication). We combine the paradigm of subspace-based communication originally developed for non-coherent point-to-point channels, with two-way relaying schemes based on physical-layer wireless network coding with denoiseand- forward (DNF). The aim is to demonstrate that denoising can be performed non-coherently and to investigate if these schemes offer an improvement over the schemes based on amplify-and-forward (AF).
415W Single-Mode CW Thulium Fiber Laser in all-fiber format (2007)

High power Tm lasers at 2um region is a great source of interest for many application including optical pumping of hybrid (fiber-solid state) lasers, bio-medical, remote sensing and plastic welding. Cladding-pumped single-mode Tm-doped fiber lasers demonstrate significant advantages over solid state Tm lasers. Over last several years multiple groups [1,2] using different techniques demonstrated power scaling of fiber bas ed Tm laser to above 100W level. In this paper, we report a development of a single mode all-fiber format Tm fiber laser with M -value of < =1.1, emission linewidth of <1 nm at 1940nm and output power exceeding 400W CW. This is a highest CW output power for a single-mode Tm fiber laser reported up to date.
Molten ionic oxides for CO2 capture at medium to high temperatures (2019)

The development of efficient low cost CO2 capture systems is a critical challenge for mitigating climate change while meeting global energy demand. Herein, we demonstrate the first liquid absorbents for CO2 capture at medium to high temperatures (500 to 700 °C). Molten ionic oxides based on sodium borate and the mixed alkali-metal borates show remarkably fast kinetics and intrinsic regenerability, with no observable deterioration in performance over multiple absorption–desorption cycles under both temperature- and pressure-swing operations. The behavior of the molten ionic oxides is ascribed to the instantaneous formation of carbonate ions in the molten oxides without the diffusional transport restrictions imposed by solid product layers characteristic of solid adsorbents. The new liquid absorbents will enable continuous processing and thermal integration via a simple absorber–desorber arrangement, thereby overcoming the challenges previously restraining high temperature CO2 capture and opening up new opportunities in clean energy production.
LaRC SmartLab Apps For Instrument Control And Data Processing: Optical Micrometer Data Visualizer (2020)

The LaRC Smart Lab applications are a series of software tools to greatly enhance researcher efficiency by streamlining and automating workflows. Python scripts and applications are increasingly being used in scientific workflows, including for instrument control and data processing. Interactive Python scripting environments such as Jupyter Lab provide powerful tools for using Python. In some use cases, the development of standalone applications with dedicated graphical user interfaces (GUIs) can enhance the utility of the code and open it up to more users, including non-programmers. Here, we describe a GUI based optical micrometer data visualization application developed as part of the LaRC SmartLab project. We highlight its use in visualizing experimental data and briefly discuss its implementation to give pointers to programmers who wish develop work based on this application's or similar co de.
Bacteriorhodopsin Material and Film Fabrication Issues for Holographic Applications (1998)

We discuss issues associated with bacteriorhodopsin (BR) materials and films that affect optical performance in holographic applications. For the D85N variant, some critical parameters include degree of hydration and recording wavelength. The quantum efficiency of the molecular state transition is observed to be apparently dependent on the illumination wavelength. We explain this effect by modeling the photo-activity of the D85N variant as two competing photocycles between the 9-cis and 13-cis retinal configurations. We are able to determine the pure excited P-state absorbance spectrum from the ground state spectrum and mixed population spectra obtained by bleaching to steady-state conditions.
Abstract A11: Regulation of CD133 by the tubulin deacetylase HDAC6 can alter cancer cell state (2010)

Abstract The CD133 antigen AC133/1 is a putative marker for enriching certain stem cells and cancer progenitor cells. Despite its wide application, the function and regulation of its expression remains unclear. Given the presence of its transcript in more differentiated cells, epigenetic regulation of CD133 transcripts alone cannot vouch for its utility as a marker. Therefore, understanding the regulation of CD133 protein expression is important for further defining the cellular state of tumor-initiating cells. We used the MAPLE system (Mak et al, Mol Cell Proteomics, 2010) to identify bona fide protein interaction partners of CD133. We present the microtubule-associated histone deacetylase 6 (HDAC6) as a physical interaction partner of CD133. This interaction was validated by co-immunoprecipitation/Western Blot analyses and by a membrane yeast two-hybrid (MYTH) assay. In order to understand the functional consequence of the HDAC6 and CD133 interaction, we used lentiviral short-hairpin RNAs to knockdown HDAC6 in multiple cell types, including the human epithelial colorectal adenocarcinoma lines Caco- 2 and HT-29 and in the retinoblastoma cell line Weri-Rb-1. Interestingly, we observed a significant reduction of CD133 protein expression. This reduction was shown to be dependent on HDAC6 deacetylase activity using a deacetlyase deficient HDAC6 mutant as well as when using the small molecule inhibitor of HDAC6, tubacin. HDAC6 promotes de-acetylation of alpha-tubulin to influence re-cycling of cell surface proteins. Furthermore, when we performed a CD133 MYTH screen against a cDNA library isolated from an adult human brain, we identified the late endosomal- and lysosomal-associated marker CD63 as an interaction partner of CD133. In fact, treatment of Caco-2 cells with tubacin resulted in trafficking of CD133 into endosomes for lysosomal degradation as determined by increased co-localization with CD63. In an attempt to study the affect of HDAC6 knockdown on cell viability, we noticed that CD133 knockdown significantly impacted cell proliferation and clonogenicity of Caco-2 cells. We determined that the cause of this is likely due to increased differentiation as determined by the level of alkaline phosphatase activity and by quantitative realtime PCR for markers of differentiated colon cells. To assess the tumorigenic potential of Caco-2 cells with reduced CD133 expression in vitro we performed soft agar colony-forming assay, which resulted in the loss of anchorage independent growth, a well-known hallmark of cancer. Together, these results suggest that CD133 can exercise a function in establishing and maintaining a primitive cancer cell state and loss or reduction of its expression marks more differentiated cancer cells that may be nontumorigenic. Citation Information: Clin Cancer Res 2010;16(14 Suppl):A11.
LOW-MOLECULAR WEIGHT PROTEINS IN NORMAL SUBJECTS AND PATIENTS WIYH INFLAMMATORY LYMPH STASIS (2004)

Interewicz, B.; Olszewski, W. L.; Leak, L. V.; Petricoin, E. F.; Ross, S.; Liotta, L. A. Author Information
Correction to “Trehalose-Based Polyethers for Cryopreservation and 3D Cell Scaffolds” (2021)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Trehalose-Based Polyethers for Cryopreservation and 3D Cell Scaffolds"Diana Diaz-DussanDiana Diaz-DussanMore by Diana Diaz-Dussanhttps://orcid.org/0000-0003-1778-3964, Yi-Yang PengYi-Yang PengMore by Yi-Yang Peng, Jayeeta SenguptaJayeeta SenguptaMore by Jayeeta Sengupta, Rebecca ZabludowskiRebecca ZabludowskiMore by Rebecca Zabludowski, Madeleine K. AdamMadeleine K. AdamMore by Madeleine K. Adam, Jason P. AckerJason P. AckerMore by Jason P. Acker, Robert N. BenRobert N. BenMore by Robert N. Ben, Piyush KumarPiyush KumarMore by Piyush Kumarhttps://orcid.org/0000-0003-3113-3933, and Ravin Narain*Ravin NarainMore by Ravin Narainhttps://orcid.org/0000-0003-0947-9719Cite this: Biomacromolecules 2021, 22, 7, 3148Publication Date (Web):June 8, 2021Publication History Published online8 June 2021Published inissue 12 July 2021https://pubs.acs.org/doi/10.1021/acs.biomac.1c00671https://doi.org/10.1021/acs.biomac.1c00671correctionACS PublicationsCopyright © 2021 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views927Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (1 MB) Get e-Alertsclose Get e-Alerts