gebhart/patrepeval huggingface dataset:
Analysis of Vehicle Longitudinal Dynamics for Longitudinal Ride Comfort (2006)

Longitudinal ride comfort is one of the most crucial features to most advanced vehicle control systems. Literature review shows that the ride comfort analysis in vehicle longitudinal motion can be divided into two categories: time domain and frequency domain. Most vehicle longitudinal control designs incorporate jerk and acceleration constraints from the time-domain comfort criterion. However, the vehicle longitudinal characteristics in the frequency range important to passenger ride comfort are rarely discussed in the vehicle control literature. This paper proposes an improved vehicle longitudinal model that captures tire and suspension modes accurately and investigates the impact of these often-ignored vehicle resonant modes to ride comfort. This study shows that the "tire-mode switching behavior" affects longitudinal ride comfort of a stopping vehicle rather than the suspension. A passenger car was tested as an example, and the collected data verified the analytical prediction from the improved vehicle longitudinal model.
Different residues in periplasmic domains of the CcmC inner membrane protein of Pseudomonas fluorescens ATCC 17400 are critical for cytochrome c biogenesis and pyoverdine‐mediated iron uptake (1998)

The inner membrane protein CcmC (CytA) of Pseudomonas fluorescens ATCC17400, which has homologues in several bacteria and plant mitochondria, is needed for the biogenesis of cytochrome c. A CcmC-deficient mutant is also compromised in the production and utilization of pyoverdine, the high-affinity fluorescent siderophore. A topological model for CcmC, based on the analysis of alkaline phosphatase fusions, predicts six membrane-spanning regions with three periplasmic loops. Site-directed mutagenesis was used in order to assess the importance of some periplasm-exposed residues, conserved in all CcmC homologues, for cytochrome c biogenesis, and pyoverdine production/utilization. Despite the conservation of the residues His-61, Val-62 and Pro-63 in the first periplasmic loop, and Leu-184, His-185 and Gln-186 in the third periplasmic loop, their simultaneous replacement with Ala only partially affected cytochrome c biogenesis and pyoverdine production/utilization. Simultaneous replacements of residues Trp-115 and Gly-116 in the second periplasmic loop substantially affected pyoverdine production/utilization but not cytochrome c production. An Ala substitution of Asp-127, in the second periplasmic loop, resulted in decreased production of cytochrome c, slower growth in conditions of anaerobiosis and reduced pyoverdine production. On the other hand, a mutation in Trp-126, also in the second periplasmic loop, totally suppressed the production of cytochrome c, whereas it had no effect on the production and utilization of pyoverdine. These results show a differential involvement of amino acid residues in periplasmic domains of CcmC in cytochrome c biogenesis and pyoverdine production/utilization.
Water‐Stabilized Three‐ and Four‐Atom Palladium Clusters as Highly Active Catalytic Species in Ligand‐Free CC Cross‐Coupling Reactions (2013)

Elite cliques: Palladium clusters with three and four atoms were found to be the catalytically active species for ligand-free palladium-catalyzed CC bond-forming reactions. These palladium cluster species could be stabilized in water and stored for long periods of time for use on demand with no loss of activity. High yields of products and turnover frequencies (TOFs) of up to 10(5) h(-1) were observed.
Replication at the telomeres of the Streptomyces linear plasmid pSLA2 (1998)

The Streptomyces linear plasmid pSLA2 initiates DNA replication bidirectionally towards its telomeres from a site located near the centre of the molecule; at the telomeres, the recessed ends of lagging strands are filled in by non-displacing DNA synthesis. Here, we report experiments that test three proposed mechanisms for lagging-strand fill-in. We present data inconsistent with recombinational or terminal hairpin models for the formation of full-length duplex pSLA2 DNA. Instead, we find that deletions in short, distantly separated homologous palindromes in the leading-strand 3' overhang prevent propagation of linear pSLA2 DNA, implicating a mechanism of palindrome-mediated leading-strand fold-back in telomere replication. We further show that circularized pSLA2 DNA molecules are opened in vivo precisely at the terminal nucleotides of telomeres, generating functional linear replicons containing native telomeres covalently bound to a protein at their 5' DNA termini. Together, our results support a model in which pairing of multiple widely separated pSLA2 palindromes anchors the 3' end of the leading-strand overhang to a site near the overhang's base -- providing a recognition site for terminal-protein-primed DNA synthesis and subsequent endonucleolytic processing. Thus, the replication of Streptomyces plasmid telomeres may have features in common with the mechanism proposed for telomere replication in autonomous parvoviruses.
ChemInform Abstract: OPTISCH AKTIVE SELENOXO‐METHYL‐PHENYL‐PROPYL‐PHOSPHORANE UND IHRE UMWANDLUNGEN (1971)

Abstract Durch Behandlung des (+)‐(S)‐Phosphans (I) mit stöchiometrischen Mengen Se in Benzol führt zum (+)‐(R)‐Selenoxophosphoran (II), während bei der Behandlung von (‐)‐(R)‐(I) als Produkt (‐)‐(S)‐(II) erhalten wird.
Three-dimensional coupled-wave model for photonic-crystal surface-emitting lasers (2012)

A coupled-wave model that affords an efficient treatment of the full three-dimensional structure of photonic-crystal surface-emitting lasers is developed. The accuracy and validity of the theory are verified via numerical simulations and experiments.
Cryogenic CMOS Performance Analysis Including BEOL Characteristics at 4K for Quantum Controller Application (2022)

Cryo-CMOS circuit performance at 4K including both BEOL and FEOL characteristics has been investigated in a 65nm bulk CMOS for the first time. ON-current (I <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</inf> ) of n/pMOSFET are improved +25%/+9% with excellent gate modulation (I <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</inf> /I <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</inf> =~10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">9</sup> ). Cu line/via resistances decrease with temperature due to reduction of phonon scattering, and −75%/−20% lower resistances are obtained at 4K. It is revealed that there is no inter-line capacitance change and no severe Joule heating effect (JHE) of Cu BEOL at 4K. The newly developed 4K-SPICE model including BEOL characteristics enables accurate CMOS circuit design at 4K, giving 5 ~ 40% faster operation of RC line with clear dependence on driver-size and interconnect-load.
Reliability of Transesophageal Pacing in the Assessment of Sinus Node Function in Patients with Sick Sinus Syndrome (1989)

The purpose of this study was to find out whether transesophageal pacing could be utilized for assessment of sinus node function in patients with sick sinus syndrome (SSS). In 17 patients with SSS (study group) we compared the results of sinus node tests obtained both in the basal state and after pharmacological autonomic blockade by endocavitary stimulation and, 24 hours later, by transesophageal pacing. In another group of 17 patients with SSS (control group), we compared the results obtained by two endocavitary studies. In "study group", sinus cycle length (SCL) and corrected sinus node recovery time (CSRT) did not show significant differences between the two studies both in the basal state and after autonomic blockade, whereas sinoatrial conduction time (SACT) was more prolonged during esophageal pacing (P less than 0.01). In "control group", sinus node measures did not show significant differences between the two studies. In the "study group," the following coefficients of correlation were obtained in the basal state; SCL, r = 0.65, CSRT, r = 0.57, SACT, r = 0.52 and after autonomic blockade: SCL, r = 0.95, CSRT, r = 0.62 and SACT, r = 0.53. In the basal state, the correlation for SCL and CSRT between the two studies was lower in the "study group" than in the "control group" (P less than 0.05), whereas after autonomic blockade the correlation for sinus node measures did not show significant differences between the two groups of patients. These data suggest that transesophageal study influences the autonomic tone regulating the sinus node; however, it is not responsible for important variations in sinus node measures.(ABSTRACT TRUNCATED AT 250 WORDS)
Evaluation of in vitro activity of manogepix against multidrug-resistant and pan-resistant Candida auris from the New York Outbreak (2020)

ABSTRACT An ongoing Candida auris outbreak in the New York metropolitan area is the largest recorded to date in North America. Laboratory surveillance revealed NY C. auris isolates are resistant to fluconazole, with variable resistance to other currently used broad-spectrum antifungal drugs, and that several isolates are pan-resistant. Thus, there is an urgent need for new drugs with a novel mechanism of action to combat the resistance challenge. Manogepix (MGX) is a first-in-class agent that targets the fungal Gwt1 enzyme. The prodrug, fosmanogepix, is currently in Phase 2 clinical development for the treatment of fungal infections. We evaluated the susceptibility of 200 New York C. auris isolates to MGX and 10 comparator drugs using CLSI methodology. MGX demonstrated lower MICs than comparators (MIC 50 and MIC 90 0.03 mg/L; range 0.004-0.06 mg/L). The MGX epidemiological cutoff value (ECV, 99% cutoff) for the tested C. auris isolates was 0.06 mg/L. MGX was 8-32-fold more active than the echinocandins, 16-64-fold more active than the azoles, and 64-fold more active than amphotericin B. No differences were found in the MGX or comparators’ MIC 50 , MIC 90 , or GEOMEAN values when subsets of clinical, surveillance, and environmental isolates were evaluated. The range of MGX MIC values for six C. auris pan-resistant isolates was 0.008-0.015 mg/L, and the median and mode MIC values were 0.015 mg/L, demonstrating that MGX retains activity against these isolates. These data support further clinical evaluation of fosmanogepix for the treatment of C. auris infections, including highly resistant isolates.
Numerical study of rolling process on the plastic strain distribution in wire + arc additive manufactured Ti-6Al-4V (2018)

Wire + arc additive manufacturing (WAAM)&amp;nbsp;employs wire as the feedstock and an arc as the energy source, to construct near net-shape components at high build rates. Ti-6Al-4V deposits typically form large columnar prior β grains that can grow through the entire component height, leading to a anisotropic and lower mechanical properties compared to the equivalent wrought alloy. Rolling is a cold-working technique that was initially used to reduce residual stresses in Ti-6Al-4V WAAM parts, however it is now used to promote grain refinement, thus increasing strength and reducing anisotropy concomitantly. It has been shown experimentally that the minimum value of the required plastic strain to refine Ti-6Al-4V is approximately 10&amp;nbsp;% or larger. The aim of this paper is to understand the effect of rolling process parameters on the plastic deformation characteristics in WAAM structures to refine the microstructure; this is needed to produce suitable design guidelines for practical applications. The effect of different rolling process parameters, in particular, rolling load, roller profile radius on the plastic strain distribution is investigated based on the finite element method.&amp;nbsp;Additionally, the effect of friction coefficient between roller and wall, as well as the modelling for the roller (e.g. deformable vs rigid roller) are investigated. Initial results show that the plastic strain distributions are insensitive to the initial stress state. For an identical rolling load, the deformable roller produces lower equivalent plastic strain. Lower friction coefficient produces higher equivalent plastic strain near the top surface but, it has an insignificant effect in the depth. However, higher friction coefficient increases the simulation time by factor two. Although larger roller profile radii lead to higher compressive residual stresses, it has nearly no noticeable effect on the depth of compressive residual stresses.
Heat Transport in Mesoscopic Systems (1998)

Phonon heat transport in mesoscopic systems is investigated using methods analogous to the Landauer description of electrical conductance. A "universal heat conductance" expression that depends on the properties of the conducting pathway only through the mode cutoff frequencies is derived. Corrections due to reflections at the junction between the thermal body and the conducting bridge are found to be small except at very low temperatures where only the lowest few bridge modes are excited. Various non-equilibrium phonon distributions are studied: a narrow band distribution leads to clear steps in the cooling curve, analogous to the quantized resistance values in narrow wires, but a thermal distribution is too broad to show such features.
Ambient‐Temperature All‐Solid‐State Sodium Batteries with a Laminated Composite Electrolyte (2020)

Abstract This study presents a sodium‐ion conductive laminated polymer/ceramic‐polymer solid‐state electrolyte for the development of room‐temperature all‐solid‐state sodium batteries. At the negative electrode side, a negative‐electrode‐benign poly(ethylene oxide) (PEO) is used as a polymer matrix into which succinonitrile (SN) is integrated to improve the room‐temperature Na + ‐ion conductivity. At the positive electrode side, a cathode‐friendly poly(acrylonitrile) (PAN) serves as a polymer matrix into which a NASICON‐type ceramic solid‐electrolyte (Na 3 Zr 2 Si 2 PO 12 ) powder is incorporated toward both the enhancement of Na + ‐ion conductivity and the prevention of Na dendrite from penetrating through the electrolyte membrane. Through a strategical management of composition, the PAN‐Na 3 Zr 2 Si 2 PO 12 ‐NaClO 4 composite and the PEO‐SN‐NaClO 4 polymer deliver a balanced Na + ‐ion conductivity. Combining the two electrolyte layers, the laminated PEO‐SN‐NaClO 4 /PAN‐Na 3 Zr 2 Si 2 PO 12 ‐NaClO 4 solid electrolyte provides a Na + ‐ion conductivity of 1.36 × 10 −4 S cm −1 at room temperature. With respect to the anodic friendly feature of the PEO‐SN‐NaClO 4 layer and the cathodic friendly feature of the PAN‐Na 3 Zr 2 Si 2 PO 12 ‐NaClO 4 layer, the laminated solid electrolyte presents a stable electrochemical window of 0–4.8 V. Room‐temperature all‐solid‐state sodium batteries fabricated with the laminated solid electrolyte, a Na‐metal negative electrode, and a Na 2 MnFe(CN) 6 positive electrode exhibit remarkably stable cyclability.
Architecture of the artifact-based collaboration system matrix (1992)

The UNC Collaboratory project is concerned with both the process of collaboration and with computer systems to support that process. Here, we describe a component of the Artifact-Based Collaboration (ABC) system, called the Matrix, that provides an infrastructure in which existing single-user applications can be incorporated with few, if any, changes and used collaboratively. We take the position that what is needed is not new tools but better infrastructure for using familiar single-user tools collectively. The paper discusses the Matrix architecture, a Virtual Screen component, and generic functions that provide conferencing, hyperlinking, and recording of users&amp;apos; actions for all applications. INTRODUCTION AND MOTIVATION Our research is concerned with both the process of collaboration and with computer systems to support that process. We focus on shared intellectual activity as required, for example, in system design and other similar tasks, in which groups of scientific and technical...
On 2-Tuple String Matching (2000)

Consider the following two problems.&#13;\nProblem 1. We are given a collection of 2-tuples T={T_1,...,T_k}&#13;\nwhere each T_i=(T_i^1,T_i^2), for two strings T_i^1&#13;\nand T_i^2. This collection may be preprocessed. A&#13;\nquery takes as input a pattern tuple P=(P^1,P^2) and&#13;\nthe problem is to determine all tuples T_i&#13;\nfor which P^1 is a substring of T_i^1 and P^2 is a substring&#13;\nof $T_i^2.&#13;\nProblem 2. We are given a collection of documents D={D_1,...,D_k}&#13;\nthat may be preprocessed. Each query is a pair of pattern&#13;\nstrings p_1 and p_2, and the goal is to determine the set &#13;\nof all documents that contain both patterns as substrings.&#13;\nIn this paper, we show that these two problems are related and make &#13;\nprogress on solving them efficiently by proposing the first non trivial results.
Pancreatic Cancer Chemoprevention Translational Workshop (2016)

Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States with a 5-year survival rate of less than 10%. The Division of Cancer Prevention of the National Cancer Institute sponsored the Pancreatic Cancer Chemoprevention Translational Workshop on September 10 to 11, 2015. The goal of the workshop was to obtain information regarding the current state of the science and future scientific areas that should be prioritized for pancreatic cancer prevention research, including early detection and intervention for high-risk precancerous lesions. The workshop addressed the molecular/genetic landscape of pancreatic cancer and precursor lesions, high-risk populations and criteria to identify a high-risk population for potential chemoprevention trials, identification of chemopreventative/immunopreventative agents, and use of potential biomarkers and imaging for assessing short-term efficacy of a preventative agent. The field of chemoprevention for pancreatic cancer is emerging, and this workshop was organized to begin to address these important issues and promote multi-institutional efforts in this area. The meeting participants recommended the development of an National Cancer Institute working group to coordinate efforts, provide a framework, and identify opportunities for chemoprevention of pancreatic cancer.
Coding for a Single Sparse Inverse Problem (2018)

We propose a coded computing technique for making the power-iteration method of solving a single sparse linear inverse problem robust to erasure-type noise. We observe that for sparse inverse problems, codes with dense generator matrices can significantly increase storage costs. Thus, we propose coding the power-iteration computation using sparse generator matrices. Surprisingly, despite the poor error-correction ability of codes with sparse generator matrices, we show through both theoretical analysis and simulations that these codes are sufficient to achieve almost the same convergence rate as noiseless power iterations, provided that a new decoding algorithm that we call “substitute decoding” is used.
Protein homeostasis in LGMDR9 (LGMD2I) – The role of ubiquitin–proteasome and autophagy–lysosomal system (2020)

Our findings indicate that autophagy and ER stress are induced in LGMDR9 muscle.
Nano-Enabled Smart Materials and Sensors for Oil and Gas Applications (2017)

Abstract This paper describes the use of nanotechnology for transforming conventional composites that are commonly used in oilfield applications into smart materials with the ability to transmit pertinent data from downhole operations and activities. The oil and gas industry already uses stimuli-responsive materials for numerous technologies including swellable elastomers in reactive packers and in heat/ fluid-activated expandable screens. This research details the digitization of stimuli-responsive materials through the integration of a network of conductive nanomaterials into an elastomer matrix. As a result, sensors with a wide array of detection capabilities become possible. For instance, it is possible to monitor the degree and rate of a material’s expansion downhole – such as in packers or sand screens. Such information can be used to detect tool deployment status, degradation, or even chemical detection. In addition, the conductivity data resulting from nano-enabled smart composites described here can be used to detect the presence of oil, water, or specific chemicals.
The new age of acne therapy: Light, lasers, and radiofrequency (2004)

Research emphasizing long-term follow-up and comparative, randomized trials is necessary to determine whether these emerging technologies will become a viable alternative to standard therapies such as antibiotics.
Supporting I/O and IPC via Fine-Grained OS Isolation for Mixed-Criticality Real-Time Tasks (2018)

Efforts towards hosting safety-critical, real-time applications on multicore platforms have been stymied by a problem dubbed the "one-out-of-m" problem: due to excessive analysis pessimism, the overall capacity of an m-core platform can easily be reduced to roughly just one core. The predominant approach for addressing this problem introduces hardware-isolation techniques that ameliorate contention experienced by tasks when accessing shared hardware components, such as DRAM memory or caches. Unfortunately, in work on such techniques, the operating system (OS), which is a key source of potential interference, has been largely ignored. Most real-time OSs do facilitate the use of a coarse-grained partitioning strategy to separate the OS from user-level tasks. However, such a strategy by itself fails to address any data sharing between the OS and tasks, such as when OS services are required for interprocess communication (IPC) or I/O. This paper presents techniques for lessening the impacts of such sharing, specifically in the context of MC2, a hardware-isolation framework designed for mixed-criticality systems. Additionally, it presents the results from micro-benchmark experiments and a large-scale schedulability study conducted to evaluate the efficacy of the proposed techniques and to elucidate sharing vs. isolation tradeoffs involving the OS. This is the first paper to systematically consider such tradeoffs and consequent impacts of OS-induced sharing on the one-out-of-m problem.
Vision-based scene representation for 3D interaction of service robots (2006)

In this paper, we present a new approach for scene understanding by an autonomous robot, using imaging sensors only. Our goal is to build in real-time a 3D representation of the scene which is suitable for further 3D interaction. We assume the scene is composed of a mix of known and unknown objects. We present a strategy to automatically build online a consistent 3D representation from a set computer vision algorithms results. We especially focus on 2 important aspects: the constraints and choices of each parts of the system, as well as the global layout of these parts, and the final step where all information are merged together to build a unique 3D representation. Results on real scene and system performance are finally showed to validate the proposed approach