gebhart/patrepeval huggingface dataset:
Stereoselective Cycloaddition of Monosubstituted Ketene to a Methyl Glyoxylate- and Threonine-Derived Imine: Synthesis of Optically Pure β-Lactamic α-Amino Ester with High Functionality (2000)

Abstract The reaction of chloroacetyl chloride and triethylamine with a chiral imine derived from the combination of methyl glyoxylate and protected L-threonine gave two optically active α-amino acid derivatives with a cis-substituted β-lactam skeleton in a 72:28 ratio. The major product is obtained in 59% yield by simple crystallisation.
Role of peptide conformation in asparagine-linked glycosylation (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRole of peptide conformation in asparagine-linked glycosylationB. Imperiali, K. L. Shannon, and K. W. RickertCite this: J. Am. Chem. Soc. 1992, 114, 20, 7942–7944Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/ja00046a068https://doi.org/10.1021/ja00046a068research-articleACS PublicationsRequest reuse permissionsArticle Views292Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
PI3K-mTOR pathway identified as a potential therapeutic target in biliary tract cancer using a newly established patient-derived cell panel assay (2018)

Biliary tract carcinoma (BTC) is an extremely malignant tumor, but available treatment options are limited. Despite of needs for novel therapies, few BTC-related resources are currently available for evaluation of candidate drugs. To address this issue, we have recently established 13 cell lines from surgical specimens from Japanese BTC patients. In the present study, we evaluated four new molecular targeting agents using our BTC cell-based assay panel with 17 BTC cell lines. PI3K/mTOR dual inhibitor LY3023414 showed activity at submicromolar concentration ranges against 13 of the 17 cell lines tested, including the ones with gemcitabine insensitivity. In conclusion, we demonstrated that in vitro study with the BTC cell line panel would be an efficient approach to screen for novel therapeutic strategies. Although this is preliminary result and further investigations are required for confirmation, PI3K/mTOR inhibitor might be a potential target for BTC drug development.
Polymères fonctionnels à architecture contrôlée: synthèse, caractérisation et applications (2006)

Journées Scientifiques ESPCI, Paris
Ultrasound imaging of cavitation using triplet pulse sequence in bubble-enhanced ultrasonic heating (2020)

Abstract High-intensity focused ultrasound (HIFU) treatment enhanced by cavitation bubbles requires monitoring of the bubbles in the treatment region to ensure the efficacy and safety. In the intraoperative guidance by ultrasound, the bubbles in the treatment region are visualized by detecting nonlinear echoes from them. A triplet pulse sequence (3P) was developed in order to solve the disadvantage of the conventional method by which it is difficult to discriminate between the nonlinear echoes generated by the nonlinear oscillation of bubbles and those by the nonlinear propagation of ultrasound. In this study, we investigated the selectivity of cavitation bubbles in imaging by 3P in various HIFU exposure sequences to improve the efficacy and safety of cavitation-enhanced HIFU therapy. This study proved that the highest contrast could be obtained by 3P in most cases and that the combination of HIFU exposure and imaging sequences was important to obtain a high contrast image.
Neuronal Restoration Following Ischemic Stroke (2013)

Neurogenesis, the birth of new neurons, occurs throughout life in the subventricular zone and produces immature neurons that migrate tangentially through the rostral migratory stream to the olfactory bulb. This migration is tightly regulated by both structural and chemical influences. Interestingly, brain insults such as ischemic stroke increase neurogenesis and redirect neuroblast migration to the injury site. This injury-redirected neurogenesis and migration is coupled with angiogenic vasculature and is influenced by many of the factors that positively and negatively affect migration under developmental or normal adult conditions. Additionally, cytokines and chemokines such as stromal cell-derived factor-1 strongly influence neuronal migration poststroke. However, neuronal repopulation or brain regeneration is extremely limited. This limitation may potentially be due to the hostile poststroke microenvironment including the formation of the physical and chemical barriers of glial scar. Furthermore, interspecies differences in poststroke neurogenesis between rodents and humans complicate the translation of experimental results to humans. Despite these challenges, many drugs and other potential therapies have recently been evaluated for potential neurogenic properties poststroke. Improved understanding of poststroke neurorepair may lead to new and more effective neurorestorative therapies.
Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling (2016)

Kinases downstream of B-cell antigen receptor (BCR) represent attractive targets for therapy in non-Hodgkin lymphoma (NHL). As clinical responses vary, improved knowledge regarding activation and regulation of BCR signaling in individual patients is needed. Here, using phosphospecific flow cytometry to obtain malignant B-cell signaling profiles from 95 patients representing 4 types of NHL revealed a striking contrast between chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) tumors. Lymphoma cells from diffuse large B-cell lymphoma patients had high basal phosphorylation levels of most measured signaling nodes, whereas follicular lymphoma cells represented the opposite pattern with no or very low basal levels. MCL showed large interpatient variability in basal levels, and elevated levels for the phosphorylated forms of AKT, extracellular signal-regulated kinase, p38, STAT1, and STAT5 were associated with poor outcome. CLL tumors had elevated basal levels for the phosphorylated forms of BCR-signaling nodes (Src family tyrosine kinase, spleen tyrosine kinase [SYK], phospholipase Cγ), but had low α-BCR-induced signaling. This contrasted MCL tumors, where α-BCR-induced signaling was variable, but significantly potentiated as compared with the other types. Overexpression of CD79B, combined with a gating strategy whereby signaling output was directly quantified per cell as a function of CD79B levels, confirmed a direct relationship between surface CD79B, immunoglobulin M (IgM), and IgM-induced signaling levels. Furthermore, α-BCR-induced signaling strength was variable across patient samples and correlated with BCR subunit CD79B expression, but was inversely correlated with susceptibility to Bruton tyrosine kinase (BTK) and SYK inhibitors in MCL. These individual differences in BCR levels and signaling might relate to differences in therapy responses to BCR-pathway inhibitors.
A New Method for Gain Prediction of Superdirective End-Fire Arrays (2022)

The problem of gain estimation of a superdirective dipole-based end-fire array is discussed in this contribution. The current method to compute the gain, for a given element radiation efficiency, is based on the array factor (AF) theory. This work is intended to show that an equivalent formulation can be done using the Spherical Wave Expansion (SWE). Besides the interest in validating the theory, the main objective is a better understanding of the radiation and attenuation phenomena that occur in compact and superdirective arrays. The limits in their practical implementations are imposed by the high sensitivity of the system. The SWE theory provides more information in the expression of the radiated field, thus unfolding the possibility to address the problem with lower sensitive solutions.
Electroceramic-polymer composite thermistors (1986)

Abstract Transition metal oxide fillers such as VO2, V2O3 and Ti2O3 were incorporated in polymeric matrices to give composite materials with low room temperature resistivities and sizable thermistor effects. Percolation limits were determined by mixing ceramic powders in different proportions with both rigid and flexible epoxy resins. These composites exhibited unusually large PTC effects with resistance increases as high as nine orders of magnitude.
Veni Vidi Dixi (2019)

The upcoming industrial revolution requires deployment of critical wireless sensor networks for automation and monitoring purposes. However, the reliability of the wireless communication is rendered unpredictable by mobile elements in the communication environment such as humans or mobile robots which lead to dynamically changing radio environments. Changes in the wireless channel can be monitored with frequent pilot transmission. However, that would stress the battery life of sensors. In this work a new wireless channel estimation technique, Veni Vidi Dixi, VVD, is proposed. VVD leverages the redundant information in depth images obtained from the surveillance cameras in the communication environment and utilizes Convolutional Neural Networks CNNs to map the depth images of the communication environment to complex wireless channel estimations. VVD increases the wireless communication reliability without the need for frequent pilot transmission and with no additional complexity on the receiver. The proposed method is tested by conducting measurements in an indoor environment with a single mobile human. Up to authors best knowledge our work is the first to obtain complex wireless channel estimation from only depth images without any pilot transmission. The collected wireless trace, depth images and codes are publicly available.
Cyber defense technology networking and evaluation (2004)

Creating an experimental infrastructure for developing next-generation information security technologies.
Analysis of acoustic scattering from fluid cylinders using a multifilament source model (1988)

A solution is presented for the problem of two-dimensional acoustic scattering from homogeneous fluid cylinders. The solution uses fictitious filamentary isotropic sources to simulate both the field scattered by the cylinder and the field inside the cylinder and, in turn, point-matches the continuity conditions for the normal component of the velocity and for the pressure across the cylinder surface. The procedure is simple to execute and is general in that cylinders of arbitrary shape can be handled effectively. Perfectly rigid cylinders are treated as reduced cases of the general procedure. Results are given and compared with available analytic solutions, which demonstrate the very good performance of the procedure.
Embedded Passive Circuit Elements in Low Temperature Co-Fired Ceramic Substrates for Aerospace Electronics (2017)

Abstract The packaging technology plays a critical role in the development of environmentally robust microelectronic systems. There is great demand for microelectronic systems that can withstand harsh environments and high temperatures in numerous applications including down-hole drilling, geothermal drilling, aerospace, heavy industrial, and automotive industries. In these applications, both sensors and interface electronics could be subjected to temperatures of 200°C and beyond. Standard plastic or epoxy based printed circuit boards are not reliable at these temperatures for long term operation. Packaging techniques such as Low Temperature Co-fired Ceramic (LTCC) offer a versatile and reliable alternative to form electronic substrates. LTCC is a multi-layer packaging system that also provides the ability to embedded passive components, such as resistors and capacitors, and thermal management structures within the substrate. This work evaluates the performance of LTCC embedded passive elements from 25°C to 225°C. A variety of passive component designs are evaluated using theoretical calculations, simulations, and measurements of fabricated test structures.
Temperature Distribution in TaOx Resistive Switching Devices Assessed In Operando by Scanning Thermal Microscopy (2023)

Understanding the physical changes during electroformation and switching processes in transition-metal-oxide-based non-volatile memory devices is important for advancing this technology. Relatively few characteristics of these devices have been assessed in operando. In this work, we present scanning thermal microscopy measurements in vacuum on TaO <sub><i>x</i></sub> -based memory devices electroformed in both positive and negative polarities and high- and low-resistance states. The observed surface temperature footprints of the filament showed higher peak temperatures and narrower temperature distributions when the top electrode served as the anode in the electroformation process. This is consistent with a model in which a hot spot is created by a gap in the conducting filament that forms closest to the anode. A similar behavior was seen on comparing the high-resistance state to the low-resistance state, with the low-resistance footprint showing a lower peak and a larger width, consistent with the gap disappearing when the device is switched from high resistance to low resistance.
Small molecule-decorated gold nanoparticles for preparing antibiofilm fabrics (2020)

The increase in antibiotic resistance reported worldwide poses an immediate threat to human health and highlights the need to find novel approaches to inhibit bacterial growth. In this study, we present a series of gold nanoparticles (Au NPs) capped by different N-heterocyclic molecules (N_Au NPs) which can serve as broad-spectrum antibacterial agents. Neither the Au NPs nor N-heterocyclic molecules were toxic to mammalian cells. These N_Au NPs can attach to the surface of bacteria and destroy the bacterial cell wall to induce cell death. Sonochemistry was used to coat Au NPs on the surface of fabrics, which showed superb antimicrobial activity against multi-drug resistant (MDR) bacteria as well as excellent efficacy in inhibiting bacterial biofilms produced by MDR bacteria. Our study provides a novel strategy for preventing the formation of MDR bacterial biofilms in a straightforward, low-cost, and efficient way, which holds promise for broad clinical applications.
Engineering of thiocyanate-free Ru(ii) sensitizers for high efficiency dye-sensitized solar cells (2013)

We synthesized a series of Ru(II) metal complexes TFRS-1, -2, -4, -21, -22 and -24 with a single 4,4′-dicarboxylic acid-2,2′-bipyridine together with two functionalized pyridyl azolate ancillary ligands consisting of pyrazolate or triazolate groups. Both photophysical measurements and DFT/TDDFT calculations were conducted to gain insight into their electronic and optical properties. The triazolate series of sensitizers TFRS-21, -22 and -24 showed an enlarged optical band gap with respect to their pyrazolate counterparts TFRS-1, -2 and -4. When employed in dye sensitized solar cells (DSCs), the triazolate sensitizers show slightly inferior JSC values due to the poor incident photon-to-current conversion efficiencies recorded compared to the pyrazolate series. Moreover, the endowed 5-(hexylthio)thiophen-2-yl substituents exert a notable hyperchromic effect and bathochromic shift in the absorption spectra, which then improves the short circuit current JSC to 18.7 and 15.5 mA cm−2 and the overall conversion efficiency to η = 10.2% and 8.25% for TFRS-4 and TFRS-24, respectively. For the evaluation of VOC, transient photocurrent and photovoltage decay measurements were carried out to compare the rates of interfacial recombination of electrons from the TiO2 conduction band to electrolyte.
Chromagenic Colour Constancy (2005)

A chromagenic camera takes two pictures of each scene. The first image is taken as normal and then the second is captured with a specially chosen chromagenic filter placed in front of the camera. In contradistinction to previous cameras that have more than 3 sensors, the aim of a chromagenic camera is not to measure more degrees of freedom in reflectance. Indeed, in a chromagenic camera the RGBs are, to a first approximation, linearly related to the filtered RGBs. However, the chromagenic filter is chosen so that this relationship depends on, and varies with illumination. The chromagenic camera is sensitive to the degrees of freedom in illumination. Chromagenic colour constancy proceeds in two stages. In pre-processing, for each light, the relation that takes filtered to unfiltered RGBs is computed. The input to colour constancy processing comprises the unfiltered and filtered RGBs captured for a given scene under unknown lighting conditions. To estimate the illuminant, the filtered responses are transformed by the pre-computed relations, and then these estimates are compared to the unfiltered counterparts. The transform that best predicts the data identifies the illuminant. Remarkably, this very simple approach works as well as, or better than, all other algorithms tested.
Semi-Analytical Effective Layer Model for the Skin in the SWIR Spectral Range (2020)

A semi-analytical method for calculating an effective model for skin is proposed showing an error less than 10%. The model can be used to study applications such as glucose and alcohol detection efficiently.
Adaptive video streaming over HTTP with dynamic resource estimation (2013)

Adaptive hypertext transfer protocol (HTTP) streaming has become a new trend to support adaptivity in video delivery. An HTTP streaming client needs to estimate exactly resource availability and resource demand. In this paper, we focus on the most important resource which is bandwidth. A new and general formulation for throughput estimation is presented taking into account previous values of instant throughput and round trip time. Besides, we introduce for the first time the use of bitrate estimation in HTTP streaming. The experiments show that our approach can effectively cope with drastic changes in connection throughput and video bitrate.
On the shadowing and limit shadowing properties (2019)

We study the relation between the shadowing property and the limit shadowing property. We prove that if a continuous self-map $f$ of a compact metric space has the limit shadowing property, then the restriction of $f$ to the non-wandering set satisfies th
"Abnormal" displacement in the reaction of 2-(N-methylpyrrolyl)methyltrimethylammonium salts with sodium cyanide (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT"Abnormal" displacement in the reaction of 2-(N-methylpyrrolyl)methyltrimethylammonium salts with sodium cyanideJohn R. Carson, John T. Hortenstine, Bruce E. Maryanoff, and Albert J. MolinariCite this: J. Org. Chem. 1977, 42, 6, 1096–1098Publication Date (Print):March 1, 1977Publication History Published online1 May 2002Published inissue 1 March 1977https://pubs.acs.org/doi/10.1021/jo00426a042https://doi.org/10.1021/jo00426a042research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Synthesis of 5a,8,8-Trimethyl-3, 10a-ethanoperhydrophenanthrene. Terpenes. VII1 (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of 5a,8,8-Trimethyl-3, 10a-ethanoperhydrophenanthrene. Terpenes. VII1L. H. Zalkow and N. N. GirotraCite this: J. Org. Chem. 1963, 28, 8, 2037–2039Publication Date (Print):August 1, 1963Publication History Published online1 May 2002Published inissue 1 August 1963https://pubs.acs.org/doi/10.1021/jo01043a022https://doi.org/10.1021/jo01043a022research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of Ionic Liquid Membranes for NOx Gas Detection and Storage Utilizing Calix[4]Arenes (2007)

Models for NOx gas sensing or storage have been prepared by the dissolution of O-tetraalkylated calix[4]arene in the 1,3- alternate conformation (Calix1) in the hydrophobic ionic liquid (IL) 1-butyl-3-methylimidazolium bis (perfluoroethylsulfonyl)imide ([C4mim]-[BETI]). When dissolved in chloroform, this calixarene has previously been shown to undergo a rapid color change when it complexes the reactive nitrosonium ion. Here we demonstrate that these color changes also are observed when the calixarene is immobilized in a nonvolatile ionic liquid.