gebhart/patrepeval huggingface dataset:
Performance evaluation of the X'tal cube PET detector using a monolithic scintillator segmented by laser processing (2011)

322 Objectives The X9tal cube is the PET detector we have developed. It consists of a scintillation crystal block segmented into cubes and multi-pixel photon counters (MPPCs) which are coupled onto all six surfaces of the crystal block. A MPPC is a small semiconductor photo-detector. Recently, we achieved 1 mm isotropic spatial resolution in this structure by identifying 1 mm cubic crystals which composed the crystal block. As a part of the X9tal cube development, we have studied laser processing technique for easier crystal segmentation instead of composing the crystal block with such fine crystals. Because the laser processing has difficulty in the depth direction of a thick crystal block, as the first trial, we made segmentation of 3 mm intervals in each three direction of an 18 mm cubic monolithic crystal. Performance of the X9tal cube with the processed crystal block (laser-X9tal) was evaluated and compared in case the crystal block was composed of 3 mm cubic crystals (array-X9tal). Methods Performance of crystal segment identification was evaluated with the 3-dimensional position histogram in which the results of Anger-type calculation of the MPPC signals in each three dimension were plotted. Each segment makes corresponding response in the histogram. A 137Cs point source was used for the measurement. For the crystal and a MPPC, we used LYSO and S10931-50P (Hamamatsu Photonics K.K., Japan, sensitive area; 3 × 3 mm2, micro cell; 50 μm2), respectively. Results Obtained position histograms showed sufficient segment identification performance of both the X9tal cubes. Average energy resolutions were 8.4 % and 10.4 % for the laser- and array-X9tals, respectively. Conclusions We showed that laser processing is feasible enough for easy and precise segmentation of the crystal block. In the next stage, we will try finer segmentation of 2 mm intervals. Research Support Funds from Japan Science and Technology Agency (JST) Development of Systems and Technology for Advanced Measurement and Analysis
GaSb-based photon counting gamma-ray detectors (2016)

The gamma-ray spectral response of MBE-grown homoepitaxial GaSb p-i-n photodiode has been investigated. The GaSb device showed great linearity and promising energy resolution across a wide range of photon energies, confirming that GaSb can offer high stopping power, high carrier mobility and low PCE that would be advantageous for its use in gamma-ray detection.
New methodology for evaluating and quantifying reticle line end shortening (2004)

A more precise and accurate method of quantifying line end effects on binary photomasks becomes necessary as reticle features continue to decrease in size. A new methodology for measuring and evaluating line ends was developed. By performing multiple step-wise measurements across a single line end feature using a fixed-width region of interest, a simulated representation of the line end profile could be generated. A high n-order polynomial fit was then applied to the resultant data set and a minimum line end value was extrapolated. This methodology reduced the measurement error directly caused by the region-of-interest (ROI) placement and sizing while, at the same time, it improved the accuracy and precision of the measurement. The generated line end profiles may be further used for modeling, simulation, or characterization.
<title>GaAs CCD readout for engineered bandgap detectors</title> (1990)

GaAs and related heterostructure charge-coupled devices (CCDs) for detector array readout multiplexer applications are described. Features of resistive-gate CCDs are compared with capacitive-gate CCDs for this application. Design examples of GaAs CCD readouts for linear and two-dimensional detector arrays with different detection methods and signal coupling schemes are described. Recent progress in two-dimensional electron gas (2DEG) Al(0.3)Ga(0.7)As/GaAs resistive-gate CCDs is also presented. The 2DEG resistive-gate CCD conventional buried-channel GaAs CCD.
Effects of Electrostatic Discharges on Bearing Grease Dielectric Strength and Composition (2016)

Bearing faults may significantly reduce the useful life of electric machines. With the advent of modern fast-switching frequency converters, electric currents induced by the high-frequency common-mode voltage of these converters have been recognized as additional, sometimes severe, contributors to bearing degradation. The degradation is understood to progress both by damaging the bearing surfaces and by altering the chemical composition of the lubrication greases, which can lead to ineffective lubrication and reduction in permissible mechanical bearing load. This paper studies the effect of grease degradation due to discharge currents on the grease dielectric strength and chemical composition of several greases typically used with electric drives. From this, conclusions on the grease selection for variable-speed drive applications are drawn.
Supplementary Figure 8 from Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion (2023)

&lt;p&gt;PDF file, 68K, EPHA4 effect on drug sensitivity.&lt;/p&gt;
Systems and processes for conversion of ethylene feedstocks to hydrocarbon fuels (2023)

Systems, processes, and catalysts are disclosed for obtaining fuel and fuel blends containing selected ratios of open-chain and closed-chain fuel-range hydrocarbons suitable for production of alternate fuels including gasolines, jet fuels, and diesel fuels. Fuel-range hydrocarbons may be derived from ethylene-containing feedstocks and ethanol-containing feedstocks.
Wide-Angle X-ray Scattering Study on Shear-Induced Crystallization of Propylene-1-Butylene Random Copolymer: Experiment and Diffraction Pattern Simulation (2011)

Shear-induced crystallization of a propylene-1-butylene random copolymer with low butylene content (5.7 mol %) was studied using time-resolved wide-angle X-ray scattering (WAXS) techniques. Polymorphism, preferred crystal orientation, crystallization kinetics, and disorder effect were investigated based on WAXS 2D whole pattern analysis. It was found that at 100 °C, the crystallite of P−B copolymer was a mixture of 80% γ-form and 20% α-form of isotactic polypropylene (iPP) crystals. The application of a step shear (shear rate = 100 s−1, shear duration =3s) induced γ-form crystals with c-axis oriented perpendicular to the shear direction. In contrast, the c-axis of α-form crystals was normally in parallel to the shear direction. Both crystallization kinetics and crystallinity were greatly enhanced by shear. The disorder effect was found to play an important role in the crystallization behavior of P−B copolymer. In the early stage crystallization, the chosen copolymer contained a large amount of structure defects, where crystals became more ordered upon annealing. The degree of crystal orientation was also found to decrease during crystallization due to the relaxation after shear.
NOx Prediction in Diesel Engines for Aftertreatment Control (2003)

Modern Diesel engines are faced with two major emission challenges in their quest to become an environmentally compatible source of motive power, Nitrogen Oxides (NOx) and Particulate Matter (PM). Advanced techniques, such as High Pressure Common Rail (HPCR) fuel injection combined with multiple injections per cycle, are commonly employed to minimize in-cylinder production of NOx and PM. However, to meet the EPA mandated standards it is essential that an aftertreatment system be used. Typical Diesel aftertreatment systems will employ some form of a NOx reducing catalyst and a particulate trap for PM removal. Lean NOx traps and Selective Catalytic Reduction (SCR) are examples of aftertreatment techniques frequently used in Diesel engine applications. Whatever the method of choice, knowledge of the feed-gas NOx concentration is essential for not only assessing the performance of the NOx reduction catalyst but also for defining the control strategy for the aftertreatment system with respect to the management of the reductant quantity to be injected. In the absence of a dynamic NOx emission model the control algorithm has to depend on either a NOx sensor upstream of the catalyst or a static map of the feedgas NOx level as some function of engine influence factors. While NOx sensors add to the overall system cost, creating an accurate and representative NOx map over the entire engine operating range can be a challenging task. A dynamic NOx model would, in theory solve, both of these problems, however it is essential that the model be simple and implementable in real time. A model that uses inputs that are not available from the standard measurement set is of little use for real time control applications as is a model that predicts the temporal and spatial NOx evolution in the engine combustion chamber as such models tend to be computationally expensive. However, it is essential that the model behave like a fast NOx sensor in predicting cycle averaged NOx emission. In this paper we present an approach to developing such a model and present results from model validation against vehicle data. The basic structure of the model relies on well-known mechanisms that describe the NOx creation and decomposition chemical kinetics. Simplifying assumptions are made to allow available measurements to be used as inputs to the model. This leads to a parametric model where the unknown parameters are estimated using Nelder Mead optimization routine available in Matlab®. Model validation against vehicle data is also presented.
Detection of acute 3,4-methylenedioxymethamphetamine (MDMA) effects across protocols using automated natural language processing (2020)

The detection of changes in mental states such as those caused by psychoactive drugs relies on clinical assessments that are inherently subjective. Automated speech analysis may represent a novel method to detect objective markers, which could help improve the characterization of these mental states. In this study, we employed computer-extracted speech features from multiple domains (acoustic, semantic, and psycholinguistic) to assess mental states after controlled administration of 3,4-methylenedioxymethamphetamine (MDMA) and intranasal oxytocin. The training/validation set comprised within-participants data from 31 healthy adults who, over four sessions, were administered MDMA (0.75, 1.5 mg/kg), oxytocin (20 IU), and placebo in randomized, double-blind fashion. Participants completed two 5-min speech tasks during peak drug effects. Analyses included group-level comparisons of drug conditions and estimation of classification at the individual level within this dataset and on two independent datasets. Promising classification results were obtained to detect drug conditions, achieving cross-validated accuracies of up to 87% in training/validation and 92% in the independent datasets, suggesting that the detected patterns of speech variability are associated with drug consumption. Specifically, we found that oxytocin seems to be mostly driven by changes in emotion and prosody, which are mainly captured by acoustic features. In contrast, mental states driven by MDMA consumption appear to manifest in multiple domains of speech. Furthermore, we find that the experimental task has an effect on the speech response within these mental states, which can be attributed to presence or absence of an interaction with another individual. These results represent a proof-of-concept application of the potential of speech to provide an objective measurement of mental states elicited during intoxication.
Combined modality therapy for tumor stage mycosis fungoides: results of a 10-year follow-up. (1988)

Twenty-one patients with tumor stage mycosis fungoides (MF) with or without lymph node (LN) involvement, were treated with total skin electron beam irradiation (TSEB) followed by six monthly cycles of systemic chemotherapy (CT) of either mechlorethamine (HN2) or cyclophosphamide (CTX) with vincristine (VCR), procarbazine, and prednisone (PRD) (COPP or MOPP). All patients had complete clearing of the skin after TSEB. However, while receiving chemotherapy, two patients developed visceral involvement and eight patients relapsed with limited cutaneous plaques (LCP). The median duration of remission was 12 months from the completion of TSEB, and all patients relapsed with cutaneous plaques within 25 months. Complete remission was again achieved using additional electron irradiation and maintenance therapy in all but one patient. Multiple cutaneous recurrences occurred in all patients. Median survival from the initiation of TSEB is 6 years. Five patients are living beyond 8 years (four off treatment without disease for 1 to 7 years). LN involvement did not influence initial response or survival. Combined modality therapy for tumor stage MF using TSEB followed by systemic CT and subsequent maintenance therapy may lead eventually to prolonged disease-free survival (DFS) in selected patients.
Quatrième partie : Résistances de nature religieuse à l'enseignement des sciences (2008)

Prochiantz Alain, Le Guyader Hervé, Prévot Alain. Quatrième partie : Résistances de nature religieuse à l'enseignement des sciences. In: Raison présente, n°168, 4e trimestre 2008. Science et laïcité. pp. 67-78.
Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene (1997)

Resistance to azole antifungal agents in Candida albicans can be mediated by multidrug efflux transporters. In a previous study, we identified at least two such transporters, Cdr1p and Benp, which belong to the class of ATP-binding cassette (ABC) transporters and of major facilitators, respectively. To isolate additional factors potentially responsible for resistance to azole antifungal agents in C. albicans, the hypersusceptibility of a Saccharomyces cerevisiae multidrug transporter mutant, delta pdr5, to these agents was complemented with a C. albicans genomic library. Several new genes were isolated, one of which was a new ABC transporter gene called CDR2 (Candida drug resistance). The protein Cdr2p encoded by this gene exhibited 84% identity with Cdr1p and could confer resistance to azole antifungal agents, to other antifungals (terbinafine, amorolfine) and to a variety of metabolic inhibitors. The disruption of CDR2 in the C. albicans strain CAF4-2 did not render cells more susceptible to these substances. When the disruption of CDR2 was performed in the background of a mutant in which CDR1 was deleted, the resulting double delta cdr1 delta cdr2 mutant was more susceptible to these agents than the single delta cdr1 mutant. The absence of hypersusceptibility of the single delta cdr2 mutant could be explained by the absence of CDR2 mRNA in azole-susceptible C. albicans strains. CDR2 was overexpressed, however, in clinical C. albicans isolates resistant to azole antifungal agents as described previously for CDR1, but to levels exceeding or equal to those reached by CDR1. Interestingly, CDR2 expression was restored in delta cdr1 mutants reverting spontaneously to wild-type levels of susceptibility to azole antifungal agents. These data demonstrate that CDR2 plays an important role in mediating the resistance of C. albicans to azole antifungal agents.
Metabolic Hormone FGF21 Is Induced in Ground Squirrels during Hibernation but Its Overexpression Is Not Sufficient to Cause Torpor (2013)

Hibernation is a natural adaptation that allows certain mammals to survive physiological extremes that are lethal to humans. Near freezing body temperatures, heart rates of 3-10 beats per minute, absence of food consumption, and depressed metabolism are characteristic of hibernation torpor bouts that are periodically interrupted by brief interbout arousals (IBAs). The molecular basis of torpor induction is unknown, however starved mice overexpressing the metabolic hormone fibroblast growth factor 21 (FGF21) promote fat utilization, reduce body temperature, and readily enter torpor-all hallmarks of mammalian hibernation. In this study we cloned FGF21 from the naturally hibernating thirteen-lined ground squirrel (Ictidomys tridecemlineatus) and found that levels of FGF21 mRNA in liver and FGF21 protein in serum are elevated during hibernation torpor bouts and significantly elevated during IBAs compared to summer active animals. The effects of artificially elevating circulating FGF21 concentrations 50 to 100-fold via adenoviral-mediated overexpression were examined at three different times of the year. This is the first time that a transgenic approach has been used in a natural hibernator to examine mechanistic aspects of hibernation. Surgically implanted transmitters measured various metrics of the hibernation phenotype over a 7-day period including changes in motor activity, heart rate and core body temperature. In April fed-state animals, FGF21 overexpression decreased blood insulin and free fatty acid concentrations, effects similar to those seen in obese mice. However, elevated FGF21 concentrations did not cause torpor in these fed-state animals nor did they cause torpor or affect metabolic parameters in fasted-state animals in March/April, August or October. We conclude that FGF21 is strongly regulated during torpor and IBA but that its overexpression is not sufficient to cause torpor in naturally hibernating ground squirrels.
A Phase I Study of Concurrent Chemotherapy (Paclitaxel and Carboplatin) and Thoracic Radiotherapy with Swallowed Manganese Superoxide Dismutase Plasmid Liposome Protection in Patients with Locally Advanced Stage III Non-Small-Cell Lung Cancer (2010)

Manganese superoxide dismutase (MnSOD) is a genetically engineered therapeutic DNA/liposome containing the human MnSOD transgene. Preclinical studies in mouse models have demonstrated that the expression of the human MnSOD transgene confers protection of normal tissues from ionizing irradiation damage. This is a phase I study of MnSOD plasmid liposome (PL) in combination with standard chemoradiation in surgically unresectable stage III non-small-cell lung cancer. Chemotherapy (carboplatin and paclitaxel) was given weekly (for 7 weeks), concurrently with radiation. MnSOD PL was swallowed twice a week (total 14 doses), at three dose levels: 0.3, 3, and 30 mg. Dose escalation followed a standard phase I design. Esophagoscopy was done at baseline, day 4, and 6 weeks after radiation with biopsies of the squamous lining cells. DNA was extracted and analyzed by PCR for the detection of the MnSOD transgene DNA. Ten patients with AJCC stage IIIA (three) and IIIB (seven) completed the course of therapy. Five had squamous histology, two adenocarcinoma, one large cell, and two not specified. Patients were treated in three cohorts at three dose levels of MnSOD PL: 0.3 (three patients), 3 (three patients), and 30 mg (four patients). The median dose of radiation was 77.7 Gy (range 63-79.10 Gy). Overall response rate for the standard chemoradiation regimen was 70% (n = 10). There were no dose-limiting toxicities reported in all three dosing tiers. It is concluded that the oral administration of MnSOD PL is feasible and safe. The phase II recommended dose is 30 mg.
Synthesis of the AB ring system of clifednamide utilizing Claisen rearrangement and Diels–Alder reaction as key steps (2015)

In order to construct the functionalized AB ring system of clifednamide, member of the class of macrocyclic tetramic acid lactams, a synthesis was developed which utilized an Ireland-Claisen rearrangement and an intramolecular Diels-Alder reaction. Starting from di-O-isopropylidene-d-mannitol the allyl carboxylate precursor for the sigmatropic rearrangement was prepared. This rearrangement proceeded diastereoselectively only in the presence of an allyl silyl ether instead of the parent enone in the side chain, as suggested by deuteration experiments. A subsequent Diels-Alder reaction yielded the target ethyl hexahydro-1H-indene-carboxylate with high diastereoselectivity. Quantum-chemical investigations of this intramolecular Diels-Alder reaction support the proposed configuration of the final product.
Emulation of two-dimensional photonic crystal defect modes in a photonic crystal with a three-dimensional photonic band gap (2001)

Using numerical simulations, we demonstrate the construction of two-dimensional- (2D-) like defect modes in a recently proposed 3D photonic crystal structure. These modes, which are confined in all three dimensions by a complete photonic band gap, bear a striking similarity to those in 2D photonic crystals in terms of polarization, field profile, and projected band structures. It is expected that these results will greatly facilitate the observation of widely studied 2D photonic-crystal phenomena in a realistic, 3D physical system.
Phase I trial of huA33 antibody plus 5-fluorouracil (5FU), leucovorin, and oxaliplatin in patients with metastatic colorectal cancer [LUD2003–005] (2007)

3022 Background: The selective targeting of tumors with monoclonal antibodies (mAb) has emerged as a new therapeutic approach in cancer therapy with the A33 glycoprotein being a promising target in colorectal cancer. Specific tumor localization and low toxicity of a humanised A33 specific mAb (huA33) has previously been demonstrated in patients with colorectal carcinoma. In the present study, we determined the safety and efficacy of the combination of huA33 and 5FU plus leucovorin and oxaliplatin (FOLFOX-4) in patients with metastatic colorectal cancer. Methods: Patients had to present with metastatic colorectal cancer with an expected survival of at least 4 months and no more than 2 different pre-treatment regimens. Patients were excluded if they had previously received oxaliplatin or huA33 mAb. Eligible patients received huA33 (10 mg/m 2 ) by iv infusion weekly for 12 weeks (cycle 1). On study day 15, standard FOLFOX-4 chemotherapy was administered every 2 weeks for 10 weeks. Responding patients received a second cycle of weekly huA33 (10 mg/m 2 ) and biweekly FOLFOX-4 chemotherapy. Results: A total of 19 patients (11 female, 8 male) with a median age of 60 years entered the study. 5 patients had received prior chemotherapy, 2 radiation therapy and 18 surgery. Toxicities observed were as expected for FOLFOX-4 treatment alone with hematological side effects to be most prominent and included (only G3 and G4) 1 anemia and 10 neutropenias. The addition of huA33 to FOLFOX-4 did not change the pattern of known non-hematological toxicities with a low rate (14%) of huA33 mAb associated allergic reactions. One sudden death occurred at cycle five that was neither therapy nor disease related. Within the 16 patients currently available for response assessment, the overall response rate was 38% with 1 CR, 5 PR and 5 disease stabilizations. Conclusion: The combination of FOLFOX-4 as standard chemotherapy for this cohort of patients in combination with the humanized A33 antibody did not increase toxicities and was well tolerated. The overall response rate of 38% is in the response range published so far for the FOLFOX-4 regimen in this setting and warrants further analysis in a larger cohort of patients. [Table: see text]