gebhart/patrepeval huggingface dataset:
Ground- and excited-state carboxylate radical chain carriers. Radical chain substitution reactions with acyl hypohalites (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGround- and excited-state carboxylate radical chain carriers. Radical chain substitution reactions with acyl hypohalitesPhilip S. Skell and Donald D. MayCite this: J. Am. Chem. Soc. 1983, 105, 12, 3999–4008Publication Date (Print):June 1, 1983Publication History Published online1 May 2002Published inissue 1 June 1983https://pubs.acs.org/doi/10.1021/ja00350a043https://doi.org/10.1021/ja00350a043research-articleACS PublicationsRequest reuse permissionsArticle Views311Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Sequential N-Arylation of Primary Amines as a Route To Alkyldiarylamines (1999)

The synthesis of unsymmetrical alkyldiarylamines from a primary amine and two aryl bromides is described. A catalyst system composed of Pd(OAc)2/(rac)-BINAP is used to prepare an alkylarylamine (1) from a primary amine and aryl bromide. The palladium-catalyzed arylation of 1, by means of a different catalyst system, affords an alkyldiarylamine. The efficiency of each catalyst for the second step depends on the electronic nature of the substrates. This method has reasonable generality and compatiblity with base-sensitive functional groups.
NKT cell subsets as key participants in liver physiology and pathology (2016)

Natural killer T (NKT) cells are innate-like lymphocytes that generally recognize lipid antigens and are enriched in microvascular compartments of the liver. NKT cells can be activated by self- or microbial-lipid antigens and by signaling through toll-like receptors. Following activation, NKT cells rapidly secrete pro-inflammatory or anti-inflammatory cytokines and chemokines, and thereby determine the milieu for subsequent immunity or tolerance. It is becoming clear that two different subsets of NKT cells-type I and type II-have different modes of antigen recognition and have opposing roles in inflammatory liver diseases. Here we focus mainly on the roles of both NKT cell subsets in the maintenance of immune tolerance and inflammatory diseases in liver. Furthermore, how the differential activation of type I and type II NKT cells influences other innate cells and adaptive immune cells to result in important consequences for tissue integrity is discussed. It is crucial that better reagents, including CD1d tetramers, be used in clinical studies to define the roles of NKT cells in liver diseases in patients.
Denormalization of visibilities for in-orbit calibration of interferometric radiometers (2005)

This paper reviews the relative calibration of an interferometric radiometer taking into account the experimental results of the first batch of receivers developed in the frame of the European Space Agency's Soil Moisture and Ocean Salinity mission. Measurements show state-of-the-art baseline performance as long as the system is capable of correcting the effect of orbital temperature swing. A method to validate internal calibration during in-orbit deep-sky views and to correct linearity errors is also presented.
Gene Therapy for Cartilage Healing (2001)

There is increasing interest in adeno-associated virus (AAV) vectors for a wide variety of gene therapy applications. AAV is a nonpathogenic human parvovirus that can mediate long-term transduction of a number of cell types without provoking a significant immune response. These properties make AAV especially attractive for use in gene therapy of rheumatoid arthritis (RA), a chronic inflammatory disease. To investigate the potential of AAV in gene therapy of arthritis, the ability of AAV to infect synovium in vitro and in vivo was tested. Three human RA synovial fibroblast cell lines and two murine (one DBA/1J and one DBA1JC3H F1) synovial fibroblast cell lines were used to test AAV transduction in vitro. The cell lines (2 10 5 cells) were infected with 10 4 particles/cell of a murine IL-10-encoding vector (AAV-mIL-10) alone or with the addition of a low titer (100 particles/cell) of an E1-, E3-deleted recombinant adenovirus to provide E4orf6 activity to enhance second-strand synthesis. The supernatants were harvested from the wells at various time points and assayed for mIL-10 expression by ELISA. Both human synovial cell lines infected with AAV alone demonstrated low-level transgene expression throughout the course of the study. However, by day 10, all human cultures coinfected with adenovirus showed a 16-to 56-fold increase in mIL-10 compared to cultures infected with AAV-mIL10 alone. By day 30, a 31-to 135-fold increase was observed. No such increase was observed in any of the mouse cell lines. To determine the AAV transduction efficiency for synovium in vivo, human RA synovial tissues obtained from patients undergoing joint-replacement surgery were implanted subcutaneously on the backs of NOD.CB17-Prkdc SCID mice. After allowing a 2-week period for engraftment, tissues were injected with 3.4 10 11 particles of AAV-luciferase alone or in combination with 1.0 10 11 particles of adenovirus. Two weeks following AAV administration, the tissues were homogenized and assayed for expression of luciferase. Only the tissues coinfected with adenovirus had luciferase levels above background. A similar experiment with AAV-LacZ demonstrated X-gal staining only of synovial tissues coinfected with adenovirus. These findings demonstrate a preferential ability of AAV to transduce human, compared to mouse, synovial tissue and suggest that second strand synthesis may be a limiting factor in gene transduction. Further studies to elucidate the mechanisms limiting gene transduction in human synovium may allow optimization of this vector for the treatment of arthritis.
Imaging Chronic Active Lesions in Multiple Sclerosis: a Consensus Statement from the North America Imaging in Multiple Sclerosis Cooperative (P11-3.009) (2023)

To develop a consensus statement for the radiological definition and measurement of chronic active lesions (CAL) and assessment of their role as disease prognosticators in multiple sclerosis (MS).
Advanced Information Processing System (AIPS)-based fault tolerant avionics architecture for launch vehicles (2002)

An avionics architecture for the advanced launch system (ALS) that uses validated hardware and software building blocks developed under the advanced information processing system program is presented. The AIPS for ALS architecture is preliminary, and reliability requirements can be met by the AIPS hardware and software building blocks that are built using the state-of-the-art technology available in the 1992-3 time frame. The level of detail in the architecture definition reflects the level of detail available in the ALS requirements. As the avionics requirements are refined, the architecture can also be refined and defined in greater detail with the help of analysis and simulation tools. A useful methodology is demonstrated for investigating the impact of the avionics suite to the recurring cost of the ALS. It is shown that allowing the vehicle to launch with selected detected failures can potentially reduce the recurring launch costs. A comparative analysis shows that validated fault-tolerant avionics built out of Class B parts can result in lower life-cycle-cost in comparison to simplex avionics built out of Class S parts or other redundant architectures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Abstract B10: Function and therapeutic implications of p53 in the stroma of pancreatic cancer (2015)

Abstract Pancreatic ductal adenocarninoma (PDA) is one of the most aggressive human cancers and is characterized by a predominant stromal compartment mainly composed of fibroblastic and immune cells. Pancreatic stellate cells (PSCs) are the main fibroblastic cells in the pancreatic tumor microenvironment. During tumor progression, they evolve into activated and proliferative myofibroblast-like cells that synthesize copious amounts of extracellular matrix (ECM) proteins and have diminished lipid storage capacity. They produce a dense fibrous stroma that obstructs intratumoral vasculature to create physical and biological therapeutic barriers. These observations suggest that strategies that normalize the stroma may enhance anti-tumor treatment strategies. Activated PSCs in pancreatic cancers encode wild type p53, raising the possibilities that p53 activation could prevent their proliferation, and induce other paracrine anti-tumor effects. Nutlin-3a is a small-molecule p53 agonist that blocks the binding of its major negative regulator, Mdm2. As Nutlin derivatives are currently in clinical trials, we tested the consequences of activating p53 by Nutlin-3a in PSCs. The data to be presented show that Nutlin-3a induces transcriptional regulation of genes that induce multiple changes consistent with quiescence. Using PSCs from patient samples, we show that p53 activation induces lipid droplet formation, decreases expression of αSMA (ACTA2), and produces growth arrest. We also observed that p53 activation inhibits TGFβ-induced transcription of genes involved in PSC activation. To assess the genome-wide effects of p53, we performed transcriptome analysis of PSCs grown in the presence or absence of Nutlin-3a. This analysis revealed that p53 inhibits the expression of genes associated with the activation of PSCs such as ECM components and induces the expression of genes implicated in lipid metabolism characteristic of the quiescent state. P53 activation also decreased expression of genes with tumor-supporting potential including cytokines, growth factors and signaling molecules. Ongoing investigations are designed to determine the consequences of stromal p53 activation on cancer cells using in vitro co-culture systems and mouse models of pancreatic cancer. Citation Format: Maya Ridinger, Annabelle Kraus, Miranda Cox, Mark Wade, Christopher Liddle, Michael Downes, Ron Evans, Geoffrey Wahl. Function and therapeutic implications of p53 in the stroma of pancreatic cancer. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Innovations in Research and Treatment; May 18-21, 2014; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2015;75(13 Suppl):Abstract nr B10.
Using bus-based connections to improve field-programmable gate-array density for implementing datapath circuits (2006)

As the logic capacity of field-programmable gate arrays (FPGAs) increases, they are increasingly being used to implement large arithmetic-intensive applications, which often contain a large proportion of datapath circuits. Since datapath circuits usually consist of regularly structured components (called bit-slices) which are connected together by regularly structured signals (called buses), it is possible to utilize datapath regularity in order to achieve significant area savings through FPGA architectural innovations. This paper describes such an FPGA routing architecture, called the multibit routing architecture, which employs bus-based connections in order to exploit datapath regularity. It is experimentally shown that, compared to conventional FPGA routing architectures, the multibit routing architecture can achieve 14% routing area reduction for implementing datapath circuits, which represents an overall FPGA area savings of 10%. This paper also empirically determines the best values of several important architectural parameters for the new routing architecture including the most area efficient granularity values and the most area efficient proportion of bus-based connections.
Gene Expression Pattern in Transmitochondrial Cytoplasmic Hybrid Cells Harboring Type 2 Diabetes-Associated Mitochondrial DNA Haplogroups (2011)

Decreased mitochondrial function plays a pivotal role in the pathogenesis of type 2 diabetes mellitus (T2DM). Recently, it was reported that mitochondrial DNA (mtDNA) haplogroups confer genetic susceptibility to T2DM in Koreans and Japanese. Particularly, mtDNA haplogroup N9a is associated with a decreased risk of T2DM, whereas haplogroups D5 and F are associated with an increased risk. To examine functional consequences of these haplogroups without being confounded by the heterogeneous nuclear genomic backgrounds of different subjects, we constructed transmitochondrial cytoplasmic hybrid (cybrid) cells harboring each of the three haplogroups (N9a, D5, and F) in a background of a shared nuclear genome. We compared the functional consequences of the three haplogroups using cell-based assays and gene expression microarrays. Cell-based assays did not detect differences in mitochondrial functions among the haplogroups in terms of ATP generation, reactive oxygen species production, mitochondrial membrane potential, and cellular dehydrogenase activity. However, differential expression and clustering analyses of microarray data revealed that the three haplogroups exhibit a distinctive nuclear gene expression pattern that correlates with their susceptibility to T2DM. Pathway analysis of microarray data identified several differentially regulated metabolic pathways. Notably, compared to the T2DM-resistant haplogroup N9a, the T2DM-susceptible haplogroup F showed down-regulation of oxidative phosphorylation and up-regulation of glycolysis. These results suggest that variations in mtDNA can affect the expression of nuclear genes regulating mitochondrial functions or cellular energetics. Given that impaired mitochondrial function caused by T2DM-associated mtDNA haplogroups is compensated by the nuclear genome, we speculate that defective nuclear compensation, under certain circumstances, might lead to the development of T2DM.
Low Si Recess on Cleaning Process by Dilute HF/SC-1 with Megasonic (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
High Performance Micro Green Laser for Laser TV (2009)

Ultra-compact, highly efficient and high-power micro green laser is newly developed for light source of laser TV. Usage of planar-waveguide devices improves efficiency, power, size, and cost of the intra-cavity SHG green laser dramatically.
IPv6 Router Advertisement Guard (2011)

Routed protocols are often susceptible to spoof attacks. The canonical solution for IPv6 is Secure Neighbor Discovery (SEND), a solution that is non-trivial to deploy. This document proposes a light-weight alternative and complement to SEND based on filtering in the layer-2 network fabric, using a variety of filtering criteria, including, for example, SEND status.
Crystal structures of Ca(ClO4)2·4H2O and Ca(ClO4)2·6H2O (2014)

The title compounds, calcium perchlorate tetra-hydrate and calcium perchlorate hexa-hydrate, were crystallized at low temperatures according to the solid-liquid phase diagram. The structure of the tetra-hydrate consists of one Ca(2+) cation eightfold coordinated in a square-anti-prismatic fashion by four water mol-ecules and four O atoms of four perchlorate tetra-hedra, forming chains parallel to [01-1] by sharing corners of the ClO4 tetra-hedra. The structure of the hexa-hydrate contains two different Ca(2+) cations, each coordinated by six water mol-ecules and two O atoms of two perchlorate tetra-hedra, forming [Ca(H2O)6(ClO4)]2 dimers by sharing two ClO4 tetra-hedra. The dimers are arranged in sheets parallel (001) and alternate with layers of non-coordinating ClO4 tetra-hedra. O-H⋯O hydrogen bonds between the water mol-ecules as donor and ClO4 tetra-hedra and water mol-ecules as acceptor groups lead to the formation of a three-dimensional network in the two structures. Ca(ClO4)2·6H2O was refined as a two-component inversion twin, with an approximate twin component ratio of 1:1 in each of the two structures.
Recent Advances in Magnesia Blended Cement Studies for Geotechnical Well Construction—A Review (2021)

The current paper presents a literature review on the studies of incorporation of magnesia (magnesium oxide) into Portland cement material from the geotechnical well construction perspective. Starting with a comparison of application conditions between civil construction and geotechnical well cementing, this work reviewed the Portland cement categorizations, magnesia manufacturing routes at first. Then, the physical-chemical-mechanical properties were investigated which includes the reactivity of magnesia, expansion influence from its hydration, and carbonation/dehydroxylation of magnesia blended Portland cement. The development of cement material hydration modeling methods is also summarized. Moreover, the experimental characterization methods have also been elucidated including composition determination, particle size analysis, volumetric variation measurement, compressive strength testing, shear-bond strength testing, transition state analysis, etc. Meanwhile, the results and conclusions were extracted from the literature. Through this route, a comprehensive understanding of the scientific research progress on magnesia blended Portland cement development for geotechnical well construction is derived. Additionally, it is concluded that incorporating magnesia into Portland cement can provide benefits for this material utilization in geotechnical well constructions provided the reasonable tuning among the characteristics of magnesia, the downhole surrounding conditions, and the formulation of the cement slurry. Satisfying these pre-conditions, the effective expansion not only mitigates the micro-annulus issues but also increases the shear bonding strength at the cementing interfaces. Moreover, the caustic magnesia introduction into Portland cement has the potential advantage on carbon dioxide geological sequestration well integrity compared with the Portland cement sheath without it because of the denser in-situ porous matrix evolvement and more stable carbon fixation features of magnesium carbonate. However, since the impact of magnesia on Portland cement strongly depended on its properties (calcination conditions, particle size, reactivity) and the aging conditions (downhole temperature, pressure, contacting medium), it should be noted that some extended research is worth conducting in the future such as the synchronized hydration between magnesia and Portland cement, the dosage limit of caustic magnesia in Portland cement in terms of CO 2 sequestration and the corresponding mechanical properties analysis, and the hybrid method (caustic magnesia, Portland cement, and other supplementary cementitious materials) targeting the co-existence of the geothermal environment and the corrosive medium scenario.
RGS13 Controls G Protein-Coupled Receptor-Evoked Responses of Human Mast Cells (2008)

IgE-mediated mast cell degranulation and release of vasoactive mediators induced by allergens elicits allergic responses. Although G protein-coupled receptor (GPCR)-induced signals may amplify IgE-dependent degranulation, how GPCR signaling in mast cells is regulated remains incompletely defined. We investigated the role of regulator of G protein signaling (RGS) proteins in the modulation of these pathways in human mast cells. Several RGS proteins were expressed in mast cells including RGS13, which we previously showed inhibited IgE-mediated mast cell degranulation and anaphylaxis in mice. To characterize how RGS13 affects GPCR-mediated functions of human mast cells, we analyzed human mast cell lines (HMC-1 and LAD2) depleted of RGS13 by specific small interfering RNA or short hairpin RNA and HMC-1 cells overexpressing RGS13. Transient RGS13 knockdown in LAD2 cells lead to increased degranulation to sphingosine-1-phosphate but not to IgE-Ag or C3a. Relative to control cells, HMC-1 cells stably expressing RGS13-targeted short hairpin RNA had greater Ca(2+) mobilization in response to several natural GPCR ligands such as adenosine, C5a, sphingosine-1-phosphate, and CXCL12 than wild-type cells. Akt phosphorylation, chemotaxis, and cytokine (IL-8) secretion induced by CXCL12 were also greater in short hairpin RGS13-HMC-1 cells compared with control. RGS13 overexpression inhibited CXCL12-evoked Ca(2+) mobilization, Akt phosphorylation and chemotaxis. These results suggest that RGS13 restricts certain GPCR-mediated biological responses of human mast cells.
Independent Control of Dot Occupancy and Reservoir Electron Density in a One-electron Quantum Dot (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation W. H. Lim, F. A. Zwanenburg, C. H. Yang, H. Huebl, M. Möttönen, K. W. Chan, C. C. Escott, A. Morello, A. S. Dzurak; Independent Control of Dot Occupancy and Reservoir Electron Density in a One‐electron Quantum Dot. AIP Conf. Proc. 23 December 2011; 1399 (1): 349–350. https://doi.org/10.1063/1.3666397 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Quantum and statistical mechanical studies of liquids. 7. Structure and properties of liquid methanol (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantum and statistical mechanical studies of liquids. 7. Structure and properties of liquid methanolWilliam L. JorgensenCite this: J. Am. Chem. Soc. 1980, 102, 2, 543–549Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/ja00522a018https://doi.org/10.1021/ja00522a018research-articleACS PublicationsRequest reuse permissionsArticle Views579Altmetric-Citations138LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts