gebhart/patrepeval huggingface dataset:
Free phase gas processes in a northern peatland inferred from autonomous field‐scale resistivity imaging (2016)

Abstract The mechanisms that control free phase gas (FPG) dynamics within peatlands, and therefore estimates of past, present, and future gas fluxes to the atmosphere remain unclear. Electrical resistivity imaging (ERI) is capable of autonomously collecting three‐dimensional data on the centimeter to tens of meter scale and thus provides a unique opportunity to observe FPG dynamics in situ. We collected 127 3‐D ERI data sets as well as water level, soil temperature, atmospheric pressure, and limited methane flux data at a site in a northern peatland over the period July–August 2013 to improve the understanding of mechanisms controlling gas releases at a hitherto uncaptured field scale. Our results show the ability of ERI to image the spatial distribution of gas accumulation and infer dynamics of gas migration through the peat column at high (i.e., hourly) temporal resolution. Furthermore, the method provides insights into the role of certain mechanisms previously associated with the triggering of FPG releases such as drops in atmospheric pressure. During these events, buoyancy‐driven gas release primarily occurs in shallow peat as proposed by the “shallow peat model.” Releases from the deeper peat are impeded by confining layers, and we observed a large loss of FPG in deep peat that may likely represent a rupture event, where accumulated FPG escaped the confining layer as suggested by the “deep peat model.” Negative linear correlations between water table elevation and resistivity result from hydrostatic pressure regulating bubble volume, although these variations did not appear to trigger FPG transfer or release.
Clinical pharmacology of carboplatin administered in combination with paclitaxel. (1997)

The clinical pharmacology of carboplatin (C) administered with paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) (P) was investigated in two phase I studies undertaken in 83 previously untreated patients with either non-small cell lung cancer or ovarian cancer. Carboplatin was administered over 30 minutes and paclitaxel over 3 hours. Both agents were given every 4 weeks. Non-small cell lung cancer patients were randomized to two administration sequences, either carboplatin followed by paclitaxel (C-->P) or the reverse (P-->C). Each patient received the alternate sequence during the second and subsequent courses. Ovarian cancer patients uniformly received paclitaxel before carboplatin. Platinum concentrations in plasma ultrafiltrate were measured via flameless atomic absorption spectrometry, and 122 concentration-time curves were obtained. For non-small cell lung cancer patients, the mean area under the concentration-time curve (AUC) per 300 mg/m2 carboplatin was 3.52 mg/mL x min (range, 1.94 to 5.83) for the sequence C-->P and 3.62 mg/mL x min (range, 1.91 to 5.01) for the sequence P-->C. No sequence-dependent effect was observed (P > .5). For ovarian cancer patients, the mean AUC per 300 mg/m2 carboplatin was 3.83 mg/mL x min (range, 2.72 to 6.10), showing no difference when compared with data derived from non-small cell lung cancer patients (P = .13). In addition, the carboplatin AUC was not influenced by increasing paclitaxel doses from 100 to 250 mg/m2. Neutropenia was the principal toxicity, and anemia was frequent. However, there was a striking lack of thrombocytopenia. Modeling of the relationship between the carboplatin AUC and the decrease in platelets revealed a 50% decrease in platelets at a carboplatin AUC (AUC50) of 6.3 mg/mL x min. This contrasts with historical data documenting a carboplatin AUC50 of 4.0 mg/mL x min. Our findings suggest that there is a considerable interaction of both drugs at the cellular level, with at least an additive effect of carboplatin on the main hematologic toxicity of paclitaxel (ie, neutropenia). There is also a protective effect exerted by paclitaxel on carboplatin-related toxicity (ie, thrombocytopenia). The clear protective effect of paclitaxel in this combination suggests that it is possible to reduce the dose interval to 3 weeks. Studies are in progress to test this hypothesis and to investigate the underlying pharmacologic interactions.
Semi‐quantitative assessment of the distribution of skin lesions in patients with psoriasis and psoriasis arthritis (2009)

Pixel-based analysis of self-reported skin lesion distributions is a powerful tool to assess systematic differences due to treatment or disease variants.
Localization of tyrosine kinase-coding region in v-abl oncogene by the expression of v-abl-encoded proteins in bacteria. (1985)

A series of plasmids containing different segments of the v-abl oncogene have been constructed to express different portions of the v-abl protein in bacteria. The tyrosine kinase activity of these proteins was determined by an in vitro assay employing histones or angiotensin II as substrates for the v-abl-encoded tyrosine kinase. These experiments show that the 5'-1.2 kilobases of v-abl is necessary and sufficient to produce an active tyrosine kinase which is functional as a monomeric soluble protein. The kinase-coding region corresponds to the minimal region of v-abl required for the transformation of fibroblasts. The kinase-coding region also coincides with the conserved protein sequences which are found in other tyrosine kinases. A compact domain of the v-abl protein including this kinase-coding region can accumulate to high levels in bacteria. The C-terminal region of the v-abl protein is not needed for the kinase activity and is rapidly degraded in bacteria.
Selective Activation of Nuclear PI-PLCbeta1 During Normal and Therapy-Related Differentiation (2016)

Nuclear phosphoinositide-phospholipase C (PI-PLC) beta1 plays a crucial role in the molecular steps that regulate cell proliferation and differentiation in several experimental models, such as myoblasts and hematopoietic cells, via interaction with other important molecular players. Indeed, PI-PLCbeta1 and its related molecules are definitely involved in hematopoiesis, and particularly in drug-induced myeloid or erythroid differentiation. Here, we review the role of nuclear PI-PLCbeta1 signalling in normal hematopoiesis, in pathogenesis and in drug-related induction of hematopoietic differentiation, with particular reference to the current therapy of Myelodysplastic Syndromes (MDS).
Crystal structures of the S6K1 kinase domain in complexes with inhibitors (2014)

Ribosomal protein S6 kinase 1 (S6K1) is a serine/threonine protein kinase that plays an important role in the PIK3/mTOR signaling pathway, and is implicated in diseases including diabetes, obesity, and cancer. The crystal structures of the S6K1 kinase domain in complexes with staurosporine and the S6K1-specific inhibitor PF-4708671 have been reported. In the present study, five compounds (F108, F109, F176, F177, and F179) were newly identified by in silico screening of a chemical library and kinase assay. The crystal structures of the five inhibitors in complexes with the S6K1 kinase domain were determined at resolutions between 1.85 and 2.10 Å. All of the inhibitors bound to the ATP binding site, lying along the P-loop, while the activation loop stayed in the inactive form. Compound F179, with a carbonyl group in the middle of the molecule, altered the αC helix conformation by interacting with the invariant Lys123. Compounds F176 and F177 bound slightly distant from the hinge region, and their sulfoamide groups formed polar interactions with the protein. The structural features required for the specific binding of inhibitors are discussed.
Peroral Endoscopic Myotomy for Achalasia Combined with Submucosal Marsupialization of an Epiphrenic Diverticulum (2019)

SCOPUS: ar.j
Feasibility, safety, and short-term outcome of leadless ultrasound-based endocardial left ventricular resynchronization in heart failure patients: results of the Wireless Stimulation Endocardially for CRT (WiSE-CRT) study (2014)

NCT01294527.
Collagen Fiber Orientation Mapping with Top Layer Discrimination using Polarized Light Spatial Frequency Domain Imaging (pSFDI) on Native Heart Tissue (2014)

We developed and demonstrated that pSDFI is able to perform the depth controlled collagen fiber orientation mapping on native heart tissue in a fast manner. pSFDI will facilitate the development of microstructure based constitutive model.
Analysis of atomic structure in InAs quantum dashes grown on AlGaAsSb metamorphic buffers (2004)

We describe structural analysis at the atomic level of InAs quantum dashes (Qdashes) grown on a GaAs substrate using an AlGaAsSb metamorphic buffer. Such characterization methods reveal the strain distribution within the quantum feature and provide insight into formation processes. The Qdashes are studied using high-resolution transmission electron microscopy that allows real-space measurement of the atomic lattice constant, a0. The variation of the lattice constant is measured along both the [110] and the [1-10] directions in the asymmetric Qdash and indicates a highly tensile core surrounded by a compressively strained matrix. The study involves both capped and uncapped dashes to observe the effect of the encapsulating matrix on the lattice constants in the dash.
Numerical Analysis of the Decomposition Method Using LTE Reference Antennas (2015)

In this document a numerical validation of the decomposition method is presented. This is a powerful method to split MIMO (multiple input multiple output) enabled UE (user equipment) tests in a radiated and a conducted part to save measurement time.
Dynamic Wavelength Allocation in Wavelength Division Multiplexing Radio-over-Fiber Access Network (2005)

We demonstrate that dynamic wavelength add-drop multiplexing technology based on a fiber Bragg grating array (FBGA) can be used to improve the efficiency of wavelengths at a burst traffic load for wavelength division multiplexing radio-over-fiber (ROF) access networks. Moreover, we also propose an upstream injection-locked longitudinal mode scheme in a remote node to offer a simple ROF interface. Experimental results demonstrate that these technologies can provide robust and reliable characteristics for large radio terminals.
Abstract 130: PF-06463922, a novel next generation ALK/ROS1 inhibitor, overcomes resistance to 1st and 2nd generation ALK inhibitors in pre-clinical models (2015)

Abstract Overcoming resistance to targeted kinase inhibitors is a major clinical challenge in oncology. For 1st and 2nd generation ALK inhibitors acquired resistance due to ALK kinase domain mutations and/or pharmacological drug resistance are major causes for disease relapse. Here, we report the preclinical evaluation of PF-06463922, a potent and brain penetrant ALK/ROS1 inhibitor with sub to low nanomolar cell potency against ALK fusions and all known clinically-acquired resistant mutations. PF-06463922 exhibited marked cytoreductive activity in tumor xenografts driven by various ALK mutants. Furthermore, PF-06463922 led to significant regression of EML4-ALK driven lung cancer brain metastasis and prolonged mouse survival. Compared to other clinically available ALK inhibitors, PF-06463922 is unique in its superior potency against a broad spectrum of acquired ALK mutations, including the highly resistant G1202R mutant and its robust antitumor activity in the brain. Furthermore, PF-06463922 demonstrated remarkable selectivity and safety margins in a variety of preclinical studies. These results suggest that PF-06463922 may be highly effective for the treatment of patients with ALK-driven lung cancers, including those who relapsed on clinically available ALK inhibitors due to ALK secondary mutations and/or brain metastases. Citation Format: Luc Friboulet, Helen Zou, David P. Kodack, Lars D. Engstrom, Qiuhua Li, Melissa West, Ruth W. Tang, Hui Wang, Konstantinos Tsaparikos, Jinwei Wang, Sergei Timofeevski, Dac M. Dinh, Hieu Lam, Justine L. Lam, Shinji Yamazaki, Wenyue Hu, Bhushankumar Patel, Divya Bezwada, Sidra Mahmood, Eugene Lifshits, Timothy Affolter, Patrick B. Lappin, Hovhannes Gukasyan, Nathan Lee, Shibing Deng, Rakesh K. Jain, Ted W. Johnson, Alice T. Shaw, Valeria R. Fantin, Tod Smeal. PF-06463922, a novel next generation ALK/ROS1 inhibitor, overcomes resistance to 1st and 2nd generation ALK inhibitors in pre-clinical models. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 130. doi:10.1158/1538-7445.AM2015-130
Optimization Of Stroke Prophylaxis Strategies In Nonvalvular AF -Drugs, Devices Or Both? (2015)

Atrial fibrillation (AF) is the most common cardiac arrhythmia with the prevalence increasing over time. AF probably afflicts ≥2% of worldwide adult population and increases with age.[1-3] In the Framingham Heart Study, the lifetime risk of having at least one episode of AF for 40-year-old men and women was 26% and 23% respectively.[4].
Role of α3 subunit‐containing GABA A receptors in benzodiazepine (BZ)‐related anti‐conflict, reinforcing, and cognitive effects (2013)

Benzodiazepine (BZ)‐type drugs are effective in treating many disorders. However, their therapeutic use is limited by unwanted side effects including abuse potential, physical dependence, and cognitive deficits. BZ‐type drugs act by binding to GABA A receptors and facilitate the effects of GABA. As there are multiple subtypes of GABA A receptors, it may be possible to attribute the therapeutic effects and side effects of BZs to different subtypes. Here, we evaluated the behavioral effects of YT‐III‐31, a novel compound which exhibits selective efficacy at α3 subunit‐containing GABA A receptors, in rhesus monkeys. We first evaluated its anti‐anxiety effects using a conflict procedure. Pretreatment of YT‐III‐31 failed to produce robust anxiolytic effects. We then tested the reinforcing effects of YT‐III‐31 by using a progressive ratio self‐administration procedure. Significant reinforcing effects compared to vehicle control were found. Finally, we examined its effects on cognitive tasks. Using an intradimensional/extradimensional attentional set‐shift task, we found that YT‐III‐31 impaired performance similar to the reference BZ, alprazolam. Together, these results suggest that α3‐GABA A receptors play important roles in BZ‐related reinforcing effects and cognitive‐impairing effects, but not the anxiolytic effects. Funding: DA011792 , DA033795 , AG03536, MH046851 , and OD011103
Investigation on the P-Type Activation Mechanism in Mg-doped GaN Films Grown by Metalorganic Chemical Vapor Deposition (1999)

An investigation on the p-type activation in Mg-doped GaN epilayers has been carried out in relation to the defect structure. The samples were grown by the metalorganic chemical vapor deposition method. Sapphire with (0001) orientation (C-face) was used as the substrate. After growth, the samples were heat-treated under flowing N 2 , at temperatures ranging from 600 to 850°C. The p-type activation arises from the dissociation of electrically inactive Mg–H complexes and the neutralization of the dissociated H + during the annealing process. The annealing temperature dependence of hole concentration and hole mobility was studied. The p-type activation process resulted in a different maximum hole concentration and an optimum annealing temperature. Subsequent microstructural characterization of our samples revealed that the dislocations play a key role in p-type conductivity and may explain the difference observed in the electrical properties. Indeed, the analyses of transmission electron microscopy (TEM) images and X-ray diffraction (XRD) data show that Mg-doped GaN exhibits a different X-ray rocking curve full width at half maximum (FWHM) and dislocation density. Furthermore, it was found that the higher the dislocation density, the higher the hole concentration. Therefore, we suggest that dislocations could act as a migration path or a neutralizing source for dissociated hydrogen impurities.
Evaluation of a multiphase drive system in EV and HEV applications (2015)

Multiphase machine drive systems have been applied in many electric propulsion fields such as aerospace and electric vehicle applications. With the development of SiC semiconductors, its superior characteristic makes compact multiphase converters possible. Moreover, by using a single chip in each switch, problems caused by an uneven current split between paralleled devices can be avoided. This paper presents a performance evaluation for a 50 kW multiphase EV/HEV drive system with 12 kV SiC MOSFETs. Power loss calculation, cost comparison and system simulation are provided to illustrate the feasibility of the proposed concept.
Phylogenetic Analysis of and Oligonucleotide Probe Development for Eikelboom Type 021N Filamentous Bacteria Isolated from Bulking Activated Sludge (2000)

Fifteen filamentous strains, morphologically classified as Eikelboom type 021N bacteria, were isolated from bulking activated sludges. Based on comparative 16S ribosomal DNA (rDNA) sequence analysis, all strains form a monophyletic cluster together with all recognized Thiothrix species (88.3 to 98.7% 16S rDNA sequence similarity) within the gamma-subclass of Proteobacteria. The investigated Eikelboom type 021N isolates were subdivided into three distinct groups (I to III) demonstrating a previously unrecognized genetic diversity hidden behind the uniform morphology of the filaments. For in situ detection of these bacteria, 16S rRNA-targeted oligonucleotide probes specific for the entire Eikelboom type 021N-Thiothrix cluster and the Eikelboom type 021N groups I, II, and III, respectively, were designed, evaluated, and successfully applied in activated sludge.
Van der Waals binding to fullerenes to a graphite plane (1993)

We develop a model that predicts the potential energy function W(R) of a spherical fullerene, C(N), near a graphite surface. R is the distance between the fullerene center of mass and the surface. The model is based on summing all the interactions between the C atoms in the fullerene and those on a graphite sheet. The atom-atom potential employed is a Lennard-Jones 12-6 potential with parameters chosen from previous treatments of graphite and of C60(S). The binding energy is suprisingly large, varying between 15 and 19 kcal/mol for C60 depending on the potential, and scales approximately as N1/2. W(R) is used to determine the force constant and fundamental frequency, as well as the Arrhenius expression A exp(-E(a)/kT), for desorption of the C(N) from the graphite surface. This information can be used to determine relative desorption rates as a function of temperature for fullerenes that are more round than cylindrical. We describe and predict the results of a feasible experiment that would measure the temperature-programmed desorption of fullerenes from a graphite surface.
Assessing the allogenic realness of the Cw1/12/15 pattern occurring in the LABScreen single antigen assay (2023)

Several technical limitations of Luminex single antigen (LSA) assays have been described so far. This study focused on a reactivity pattern observed in many sera that cannot be explained by eplets described in the Epitope Registry database and sometimes appearing against a self-HLA allele or antigen. In most cases, this pattern is revealed by a discrepant result when compared with other assays (Luminex PRA, cell-binding assays such as flow cytometry cross match, LSA from another manufacturer…). We focus here on the Cw1/12/15 pattern appearing on the LABScreen class I LSA provided by One Lambda. We documented its behavior using this LSA after acid denaturation of the beads, using Lifecodes LSA from Immucor, and adsorption of sera either on spleen mononuclear cells from deceased donors or on single HLA transfected cell clones. We studied 33 sera from different patients positive for the three Cw beads, selected from our routine patients' LSA database. Nine patients had transplants from a Cw12 or Cw15 donor without any pejorative evolution of the graft, nor post-transplant MFI (mean fluorescence intensity) increase of the Cw1/12/15 beads. A significant increase of MFI was observed after acid denaturation of the LABScreen beads. All sera tested by Lifecodes LSA were negative for these Cw beads. Finally, we found no significant difference of MFI after adsorption on cells from either origin. Therefore, the Cw1/12/15 pattern appears to be a false positive reactivity of the LABScreen single antigen assay.
Colloquium: Physics of optical lattice clocks (2011)

Recently invented and demonstrated optical lattice clocks hold great promise for improving the precision of modern time keeping. These clocks aim at the ${10}^{\ensuremath{-}18}$ fractional accuracy, which translates into a clock that would neither lose nor gain a fraction of a second over an estimated age of the Universe. In these clocks, millions of atoms are trapped and interrogated simultaneously, dramatically improving clock stability. Here the principles of operation of these clocks are discussed and, in particular, a novel concept of magic trapping of atoms in optical lattices. Recently proposed microwave lattice clocks are also highlights and several applications that employ the optical lattice clocks as a platform for precision measurements and quantum information processing.
Hierarchical Porous Carbon Cathode for Lithium–Sulfur Batteries Using Carbon Derived from Hybrid Materials Synthesized by Twin Polymerization (2018)

Abstract A new route of fabrication of cathodes for lithium–sulfur (Li–S) batteries with high cycle stability is reported. The cathodes are fabricated using porous carbon materials obtained from hybrid materials synthesized by twin polymerization on sulfonated polystyrene microparticles. The sulfonic acid groups act as room temperature catalyst for twin polymerization resulting in the formation of nanostructured phenolic resin/silica hybrid materials on the surface of sulfonated polystyrene particles. The shell formed by phenolic resin is transformed into carbon by simple pyrolysis and the polystyrene core is decomposed simultaneously at the pyrolysis temperature yielding porous carbon/silica nanocomposite hollow spheres. After silica removal, a hierarchical, highly porous carbon is obtained. Melt mixing of the carbon with sulfur is used for the fabrication of cathodes for Li–S batteries. The presence of silica on one hand imposes strength to the sphere wall during the carbonization and depolymerization of polystyrene, and on the other hand generates microporous carbon material for lithium–sulfur batteries. The nanostructured hybrid cathode allows very high capacity of 800–1000 mAh g sulfur −1 and remarkable reversible cycling stability and rate capability over 200 cycles at 0.1C rate and over 440 cycles at 1C rate for Li–S batteries.
Enhancing the Performance of the Marine and Tidal Current Converters Using DC-DC Boost Converter (2010)

Due to highly demand on the renewable energy sources as a free and a clean power resource, extracting energy from unsteady flow using marine and tidal current turbines has a special focusing nowadays. For their resource characteristic, extracting energy from them needs more simple and robust converter in order to avoid the drawbacks of the mechanical system such as gearbox and makes the marine/tidal current energy more reliable. The required AC-DC-AC conversion system equipped with DC-DC boost converter has been designed. To investigate the efficient performance of that conversion system especially at low current speed, different operating conditions were studied; the system was tested with/without boost converter at different current speeds operation. Moreover, the effect of including boost converter on the total harmonic distortion THD is checked.