gebhart/patrepeval huggingface dataset:
Dielectric-loaded microwave cavity for high-gradient testing of superconducting materials (2011)

A superconducting microwave cavity has been designed to test advanced materials for use in the accelerating structures contained within linear colliders. The electromagnetic design of this cavity produces surface magnetic fields on the sample wafer exceeding the critical limit of Niobium. The ability of this cavity to push up to 4 times the critical field provides, for the first time, a short sample method to reproducibly test these thin films to their ultimate limit. In order for this Wafer Test cavity to function appropriately, the large sapphire at the heart of the cavity must have specific inherent qualities. A second cavity was constructed to test these parameters: dielectric constant, loss tangent, and heat capacity. Several tests were performed and consistent values were obtained. The consequences of these measurements were then applied to the Wafer Cavity, and its performance was evaluated for different power inputs. The Q_0 of the cavity could be as low as 10^7 because of the sapphire heating, therefore removing the ability to measure nano-resistances. However, with additional measurements in a less complex environment, such as the Wafer Test Cavity, the Q_0&#13;\ncould be higher than 10^9.
Cu-Exchanged CHA-Type Zeolite from Organic Template-Free Synthesis: An Effective Catalyst for NH3-SCR (2020)

A Cu-containing CHA-type zeolite was prepared via aqueous ion exchange of the CHA zeolite from organic template-free synthesis. The thus-obtained template-free Cu-CHA showed the best catalytic performance (i.e., high low- and high-temperature reactivity, wide temperature-window, and high hydrothermal stability) in ammonia selective catalytic reduction (NH3-SCR) of NOx among three investigated Cu-CHA zeolites. Different Cu ion distributions of these Cu-CHA catalysts were confirmed by deconvolution of NO adsorbed Fourier transform infrared spectra; the Cu-containing template-free CHA catalyst has a high amount of isolated Cu2+ in a six-membered ring (6MR). Furthermore, the framework Al distribution is investigated by 29Si MAS NMR analysis, indicating that the catalyst has a high fraction of paired Al sites, which stabilize Cu2+ ions in the 6MR, leading to a high ability to resist the harsh hydrothermal aging.
Open hole and compression after impact testing of carbon fibre/epoxy laminates and the influence of environmental exposure (2016)

The presented work contains the results of a mechanical investigation of two types of prepreg laminates. The behaviour in open hole tension, open hole compression, and compression after impact loading is investigated. Preliminary observations of the development of damage under dynamic loading are discussed, as well as the influence of exposing the test samples to various environmental conditions prior to testing.environmental conditions prior to testing.
Resolving Subcellular miRNA Trafficking and Turnover at Single-Molecule Resolution (2017)

Regulation of microRNA (miRNA) localization and stability is critical for their extensive cytoplasmic RNA silencing activity and emerging nuclear functions. Here, we have developed single-molecule fluorescence-based tools to assess the subcellular trafficking, integrity, and activity of miRNAs. We find that seed-matched RNA targets protect miRNAs against degradation and enhance their nuclear retention. While target-stabilized, functional, cytoplasmic miRNAs reside in high-molecular-weight complexes, nuclear miRNAs, as well as cytoplasmic miRNAs targeted by complementary anti-miRNAs, are sequestered stably within significantly lower-molecular-weight complexes and rendered repression incompetent. miRNA stability and activity depend on Argonaute protein abundance, whereas miRNA strand selection, unwinding, and nuclear retention depend on Argonaute identity. Taken together, our results show that miRNA degradation competes with Argonaute loading and target binding to control subcellular miRNA abundance for gene silencing surveillance. Probing single cells for miRNA activity, trafficking, and metabolism promises to facilitate screening for effective miRNA mimics and anti-miRNA drugs.
Combined transmit beamforming and channel-aware scheduling for interference mitigation in femtocells (2012)

The introduction of femtocells in mobile networks gives rise to new co-layer and crosslayer interference scenarios. To mitigate interference, several approaches have been proposed in the literature including, e.g., transmit beamforming (TBF), power control, and fractional frequency reuse. In this article, we present an interference mitigation approach that relies on a low-rate control channel between the victim terminal and the interfering femto access point (FAP). The proposed method combines both, practical TBF schemes and simple one-bit channel-aware scheduling algorithms. We show that the proposed method can be effectively used not only to mitigate interference among FAPs, but also to balance user rates in adjacent cells with small signaling overhead.
Bag of Words and Local Spectral Descriptor for 3D Partial Shape Retrieval (2011)

This paper presents a 3D shape retrieval algorithm based on the Bag of Words (BoW) paradigm. For a given 3D shape, the proposed approach considers a set of feature points uniformly sampled on the surface and associated with local Fourier descriptors; this descriptor is computed in the neighborhood of each feature point by projecting the geometry onto the eigenvectors of the Laplace-Beltrami operator, it is highly discriminative, robust to connectivity and geometry changes and also fast to compute. In a preliminary step, a visual dictionary is built by clustering a large set of feature descriptors, then each 3D shape is described by an histogram of occurrences of these visual words. The performances of our approach have been compared against very recent state-of-theart methods on several different datasets. For global shape retrieval our approach is comparable to these recent works, however it clearly outperforms them in the case of partial shape retrieval.
1-D elastic immersive wave experimentation in an aluminum beam (2019)

In immersive wave experimentation, a physical experimentation domain is immersed in a larger numerical simulation such that waves in the physical domain drive the numerical simulation and vice-versa. For elastic media, the interaction takes place through sources and sensors at the free surface, where the wavefield is measured and the immersive boundary condition (IBC) is computed and applied. We present a theoretical and experimental study on the implementation of 1-D IBCs for elastic waves in an aluminum beam. Utilizing a 3-D Scanning Laser Doppler Vibrometer (LDV), we measure longitudinal and shear components of a wavefield along the beam. The recorded wavefield is then separated into incident and reflected components and converted into traction. By applying the incident wavefield traction as a boundary condition using a three-component piezo-actuator, we can effectively mitigate broadband longitudinal and shear wave reflections from the boundary, provided the piezo-actuator is calibrated to behave as an idealized point force source. Furthermore, we dynamically link the physical experiment with a numerical background model, introducing virtual scattering. Our results enable elastic immersive wave experimentation at lower frequencies closer to those encountered in real-world scenarios.
Biomarker analysis of patients with follicular lymphoma treated with ibrutinib in the phase 2 DAWN study (2017)

Background: Ibrutinib (ibr), a first-in-class, oral, covalent Bruton's tyrosine kinase inhibitor, is approved for and has demonstrated robust activity in various B-cell non-Hodgkin lymphomas. The DAWN study (FLR2002, NCT01779791) investigated the efficacy and safety of single-agent ibr in chemoimmunotherapy (CIT)-refractory follicular lymphoma (FL) patients (pts). Ibr may modulate T-cell activity via inhibition of interleukin-2-inducible T-cell kinase by activating T-helper 1 (Th1) cells (Dubovsky, et al. Blood 2013). We describe the effect of ibr treatment on T-cells and cytokines in pts in the DAWN study. Methods: This was a multicenter, single-arm, phase 2 study of ibr in FL pts with ≥2 prior lines of therapy and progressive disease (PD) ≤ 12 months after CIT regimen. Pts received ibr (560 mg QD) on a 21-day cycle until PD or toxicity. A protocol amendment allowed continued ibr treatment in clinically stable/improving pts with radiological evidence of PD (new lesion/increase ≥50%) to account for “pseudo-PD”. The primary end point was the overall response rate (ORR) (complete response [CR] + partial response). Flow cytometry assessed T-cell subsets in peripheral blood at baseline (C1D1) and at cycle 3 (C3D1) for 57 pts (14 responders, 43 nonresponders); cytokine and chemokine analyses were performed at C1D1 and at cycle 2 (C2D1) for 50 pts (21 responders, 29 nonresponders). Results: The DAWN study results have been presented (Gopal A, et al. ASH 2016); ibr achieved an ORR of 20.9% (CR rate, 10.9%). Flow cytometry analysis revealed CD4 + CD25 + CD127− Tregs were downregulated at C3D1 in responders (CR + PR, mean decrease 17 to 12.9% CD4, p = 0.02) but not in nonresponders (11.5 to 10.4% CD4, p = 0.17). There were no differences between responders and nonresponders in a large panel of inflammation-related cytokines and chemokines at C1D1, confirmed by gene expression profiling in the tumor. After 21 days, Th1 cytokines interferon (IFN)-γ and interleukin (IL)-12 were increased in responders but decreased in nonresponders (p = 0.0025 and p = 0.035, respectively; Figure). The chemokines IFN-γ-induced protein 10 and monocyte-chemotactic protein 3 were decreased in responders but increased in nonresponders (p = 0.022 and 0.016, respectively). Available data in pseudo-PD pts showed a similar trend of decreased Tregs at C3D1 as responders, but the cytokines showed a similar trend as nonresponders. Keywords: follicular lymphoma (FL); ibrutinib; immunomodulators (IMIDs)
Double rayleigh scattering noise in lumped and distributed raman amplifiers (2003)

An improved analytical expression of the multiple path interference (MPI) induced by double Rayleigh scattered signal in fiber Raman amplifiers (FRAs), valid both for lumped and distributed FRAs, is derived with a small signal model. The expression is validated both by comparison with an exact solution and by MPI measurements on four different lumped and distributed Raman amplifiers.
Glial Cell–Mediated Deterioration and Repair of the Nervous System after Traumatic Brain Injury in a Rat Model as Assessed by Positron Emission Tomography (2010)

Traumatic brain injury (TBI) is one of the most acute degenerative pathologies in the central nervous system, and in vivo indices enabling an assessment of TBI on a mechanistic basis have yet to be established. The aim of this work was to pursue neuroinflammatory changes and their link to functional disruptions of traumatically-damaged neurons in a rat model of TBI by longitudinal positron emission tomographic (PET) assays. TBI was induced in the unilateral frontal cortex of craniotomied rats according to a lateral fluid percussion brain injury protocol. The use of [(18)F]fluoroethyl-DAA1106 as a PET tracer for translocator protein (TSPO) permitted demonstration of the inflammatory response to the injury, peaking at 1 week after impact. This alteration was parallel to metabolic deficits assessed by PET with [(18)F]fluorodeoxyglucose, but the difference in TSPO levels between impacted and non-impacted frontal cortices was more than threefold of the interlateral metabolic difference, indicating superiority of TSPO imaging for sensitive detection of post-traumatic pathologies. Comparative PET, autoradiographic. and immunohistochemical investigations illustrated the primary contribution of hypertrophic microglia and macrophages to acute TSPO signals in the vicinity of the impact. Astrocytes also formed a TSPO-positive glial scar encompassing necrotic inflammation, and were clustered with PET-detectable TSPO signals in the bilateral external and internal capsules at late stages, putatively reacting with diffuse axonal injury. These observations support the applicability of TSPO-PET as an imaging-based preclinical and clinical biomarker assay in TBI, and indicate its potential capability to clarify aggressive and protective roles of glial responses to injury when combined with emerging anti-inflammatory and immunomodulatory treatments.
Prüfung des kernspintomographischen Kontrastmittels Gadolinium-DTPA am Menschen (1984)

In an initial clinical trial we examined the tolerance and the influence exercised on signals in nuclear magnetic resonance tomography by gadolinium-DTPA. In an open study, 4 dosages between 0.005 and 0.25 mmol Gd-DTPA/kg body-weight were tested on 5 healthy volunteers each. To ensure renal elimination of Gd-DTPA, NMR images were produced (0.35 T Magnetom) visualising the kidneys and urinary bladder before and more than 60 minutes after application of the contrast medium. The article shows in what manner the image is influenced by the dosage of the contrast medium and also by the time interval elapsing between injection of the contrast medium and production of the NMR tomogram. - Finally, first clinical results of NMR tomography contrast medium application are demonstrated in the case of 5 patients with cerebral tumours.
Leukotoxin (Leukothera™), a Targeted Therapy for Hematological Malignancies (2010)

Abstract Abstract 3284 Leukotoxin (Leukothera™) is a bacterial protein toxin that naturally targets and kills disease associated white blood cells (WBCs) expressing the activated form of leukocyte function antigen-1 (LFA-1). While leukotoxin has minimal effects on resting and healthy cells, it causes significant death of malignant WBCs associated with leukemias and lymphomas. Leukotoxin is a unique biologic in that it already provides both toxicity and specificity without requiring fusion of the protein to other molecules such as antibody fragments or cytokines. In vivo efficacy was demonstrated in an HL-60 SCID mouse leukemia model previously. In the present work, we compared leukotoxin to the standard chemotherapeutic agents, doxorubicin and cytarabine in a SCID mouse model using THP-1 leukemia cells. Mice (n=14 per group) were injected with THP-1 cells intravenously (i.v.) and then administered either leukotoxin or standard agents i.v. Mice received three doses, once daily, of leukotoxin (1.5 mg/kg) or five doses of doxorubicin (0.5 mg/kg) or cytarabine (10 mg/kg) once daily. Leukemic mice that were treated with leukotoxin maintained and increased body weight more effectively than those which received vehicle alone or the standard agents. The leukotoxin-treated mice showed significantly (p&lt;0.001) higher mean survival than mice treated with vehicle or cytarabine over the 60-day observation period. Necropsy and histopathology of animals after the 60-day period revealed that test animals treated with vehicle or standard agents developed internal tumors on organs such as the thymus and lymph nodes. In contrast, none of the leukotoxin-treated mice developed internal tumors. To determine if leukotoxin could block migration of malignant cells, and thus formation of internal tumors, we performed a cellular migration assay using activated monocytes and human brain endothelial cells. It was found that even a low dose of leukotoxin (10 ng/ml) caused significant suppression (&gt;80%) of monocyte migration across an endothelial barrier. Hence, leukotoxin has the potential to not only deplete malignant WBCs, but may also prevent their spread to other tissues. To test the general safety of leukotoxin, mice were injected with 1 mg/kg for three weeks. None of the mice showed signs of illness or changes in normal behavior and all continued to gain weight throughout the study period. In addition, to determine if a neutralizing antibody response to leukotoxin was generated, we challenged mice with high doses of leukotoxin and assayed monoclonal antibody from ten independent hybridomas. Results showed that antibody was able to bind to and recognize leukotoxin, but did not cause significant neutralization in a bioassay. In conclusion, leukotoxin may represent a highly effective and safe option for patients with hematologic malignancies, especially those with relapsed and refractory disease. Disclosures: Kachlany: Actinobac Biomed, Inc.: Consultancy, Equity Ownership. Belinka:Actinobac Biomed, Inc.: Employment, Equity Ownership.
Exploration of Ceramic Dielectrics for Microscale Dielectric Barrier Discharge Plasma Actuators (2013)

Microscale dielectric barrier discharge plasma actuators have been fabricated and experimentally characterized utilizing silicon dioxide for the dielectric barrier with thicknesses of 5 and 10 μm. Using a ceramic dielectric material provides improved device reliability by increasing the lifetime of microscale DBD actuators. Power, velocity, and thrust/force data are reported for several device geometries. The plasma net body force is computed by integrating the spatial body force, and the actuator’s thrust is found using a control volume analysis. By estimating the wall shear force, the plasma force may be recovered for comparison. These two methods show good agreement in estimating the plasma body force.
A rapid screening test to determine the antioxidant potencies of natural and synthetic antioxidants (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA rapid screening test to determine the antioxidant potencies of natural and synthetic antioxidantsWilliam A. Pryor, Joseph A. Cornicelli, Larry J. Devall, Bradley Tait, B. K. Trivedi, D. T. Witiak, and Mingdan WuCite this: J. Org. Chem. 1993, 58, 13, 3521–3532Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/jo00065a013https://doi.org/10.1021/jo00065a013research-articleACS PublicationsRequest reuse permissionsArticle Views1014Altmetric-Citations254LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analysis of Human Colon Tissue Cell Composition Using Single-Cell Gene-Expression PCR (2013)

In both health and disease, human tissues are composed of a multiplicity of cellular types, many of which unknown and uncharacterized. Accurate, quantitative measurements of tissue cell composition are difficult to perform, as classic analytical techniques, such as flow cytometry and immunohistochemistry, depend on the availability of antigen-specific monoclonal antibodies and allow only for a few markers to be tested in parallel on each cell. As a result, the full repertoire of cell types contained in a tissue, and their relative abundance in physiological and pathological situations, remain largely unexplored. We developed a novel analytical platform for the study of tissue cell composition, based on single-cell gene-expression RT-PCR (SINCE-PCR). We tested the precision, accuracy and sensitivity of the method, and we used it to investigate the cell composition of human colon epithelia, both normal and cancerous. Starting from primary surgical specimens, we obtained single-cell suspensions of colon epithelial cells and we used flow cytometry to sort them one-by-one, in arrays of hundreds of single cells. We then exploited a microfluidic platform to analyze each individual cell for the expression of 96 genes in parallel, and we used statistical clustering algorithms to associate cells with similar gene-expression profiles. This novel approach led to the discovery of new epithelial cell populations and novel biomarkers to differentially label them. Moreover, it showed that, in human colon tumors, the heterogeneity observed among cancer cells closely mirrors the cellular diversity observed in normal epithelia, where immature progenitor cells intermingle with distinct subsets of mature goblet cells and enterocytes. Finally, SINCE-PCR analysis of monoclonal colon cancer xenografts, obtained from injection of a single (n = 1) “cancer stem cell” into immunodeficient mice, formally proved that this diversity is epigenetic in nature and originates from multi-lineage differentiation processes, reminiscent of physiological stem-cell systems.
Supplementary Figure 5 from Soluble CD200 Is Critical to Engraft Chronic Lymphocytic Leukemia Cells in Immunocompromised Mice (2023)

&lt;p&gt;PDF file - 125K, Engraftment of CD19+CD5+ CLL cells in peritoneal cavity: CD19+CD5+ CLL cells within the CD45+ population in the peritoneal cavity of mice that received one of three plasma infusions: sCD200lo normal plasma (upper panel), sCD200hi CLL plasma (middle panel), or sCD200lo normal plasma + CD200Fc (lower panel). Representative data from individual animals from each group are shown&lt;/p&gt;