gebhart/patrepeval huggingface dataset:
Evaluation of a modified sinar 54M digital camera at the National Gallery of Art, Washington DC during April, 2005 (2005)

On April 26 – 27 2005, the RIT team brought their prototype Sinar 54M camera system to the National Gallery of Art’s Imaging Department. The team included Lawrence Taplin, Mitchell Rosen, and Roy Berns. RIT brought a spectroradiometer to measure the daylight fluorescent viewing illumination and if time allowed, NGA’s CRT display. They also brought a Macintosh G5 to control the camera and for image processing. NGA is using a production Sinar 54M. This enabled a direct comparison between NGA’s digital imaging workflow and the RIT workflow. Both cameras used the same lighting, Broncolor pulsed Xenon, lighting geometry, and photography studio. A set of test targets was imaged by each camera system. In addition, Matisse’s Pot of Geraniums, previously imaged by RIT using their 31-channel spectral camera,1-3 was also imaged. The digital masters from each camera system were converted to an output profile for an Epson Ultrachrome inkjet printer. One-to-one prints were made for the Matisse painting and compared with the actual painting under the daylight fluorescent viewing environment. The RIT prototype camera and the print comparison were evaluated by NGA staff from the imaging, conservation, and finance departments.
The Use of Convolution Type Curves for the Analysis of Drawdown and Buildup Tests (1988)

Abstract One of the most important objectives of transient well-test interpretation is to recognize the well-reservoir system (identification) that is being tested, before estimating its parameters such as permeability, skin, and reservoir pressure. This paper presents a procedure for system identification and parameter estimation for single layered reservoirs using downhole pressure and flow rate measurements. However, the procedure can also be applied to commingled reservoirs if each zone is tested in accordance with the multilayer testing technique. The procedure consists of three steps. The first is a system and flow regimes identification (diagnostic) from deconvolution, and specific convolutions and their derivatives. The second step is to obtain all possible parameters and to refine the model further from flow regime analyses and type curve matching using the rate normalized pressure and its derivatives with a few selected models. Any parameter estimated from the flow regime analyses is used as initial guesses for type curve matching. The final step is the verification that allows an automatic estimation of parameters using the most probable model. At the final step, the selected model should satisfy all observed transient measurements and the past production history as well as geological and well log information. The procedure for transient well test interpretation presented in this paper demonstrates the advantages of using downhole flow rate and pressure measurements. In addition, the paper explores the use of the Gladfelter deconvolution of pressure and flow rate data for model identification. The convolution type curves (CTC) are presented. The interpretation procedure was successfully applied to a field well test example.
Comparison of Native Porcine Skin and a Dermal Substitute Using Tensiometry and Digital Image Speckle Correlation (2012)

Dermal substitutes are currently used in plastic surgery to cover various soft tissue defects caused by trauma, burns, or ablative cancer surgery. Little information is available on the biomechanical properties of these dermal substitutes after adequate incorporation as compared to normal skin. Determining parameters such as tensile strength in these skin substitutes will help us further understand their wound healing properties and potential in developing artificial tissue constructs. We hypothesize that a dermal substitute has a lower stress-strain curve and altered stress-induced deformation quantified with tensiometry and digital image speckle correlation (DISC) analysis. Two separate 5×10-cm full-thickness wounds were created on the dorsum of 3 female swine. Fibrin glue was applied before either a full-thickness skin graft (FTSG) or application of artificial dermal matrix. On day 42, cultured autologous keratinocytes were applied as a cell sheet to the wound covered with Integra. On day 56, the wounds were fully excised and fresh tissue specimens, including normal skin, were stored in a physiological solution and prepared for analysis. Rectangular samples were excised from the center of each specimen measuring 4×4×30 mm. Using a tensiometer and DISC analysis, we evaluated the tensile strength of 3 different groups of skin, namely, normal, FTSG, and Integra. There is a significant difference between the Integra specimen when compared to normal skin and FTSG. We found a minimal difference in the stress-strain curves of the latter two. Integra alone shows plastic deformation with continued stretching before ultimate midline fracture. There is significant change between the Young's moduli of the normal skin and the Integra, whereas there is little difference between the FTSG and the normal skin; DISC confirms this analysis. The normal skin and FTSG show a convergence of vectors to a linear plane, whereas Integra shows very little organization. Using 2 different methods of analysis, we have shown a dermal substitute does not display similar biomechanical properties after adequate incorporation. These major tensile strength differences are shown between normal, grafted, and Integra constructs under physiological conditions. These properties will lead to further understanding of artificial tissue and engineered constructs in laboratory and clinical applications.
Simple Proofs of Upper and Lower Envelopes of Van Der Pauw’s Equation for Hall-Plates with an Insulated Hole and Four Peripheral Point-Contacts (2022)

For plane singly-connected domains with insulating boundary and four point-sized contacts, 0 3 C C , van der Pauw derived a famous equation relating the two trans-resistances 01,23 12,30 , R R with the sheet resistance without any other parameters. If the domain has one hole van der Pauw's equation becomes an inequality with upper and lower bounds, the envelopes. This was conjectured by Szymaski et al. in 2013, and only recently it was proven by Miyoshi et al. with elaborate mathematical tools. The present article gives new proofs closer to physical intuition and partly with simpler mathematics.
Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited by the power of light (2012)

The use of low level laser (light) therapy (LLLT) has recently expanded to cover areas of medicine that were not previously thought of as the usual applications such as wound healing and inflammatory orthopedic conditions. One of these novel application areas is LLLT for muscle fatigue and muscle injury. Since it is becoming agreed that mitochondria are the principal photoacceptors present inside cells, and it is known that muscle cells are exceptionally rich in mitochondria, this suggests that LLLT should be highly beneficial in muscle injuries. The ability of LLLT to stimulate stem cells and progenitor cells means that muscle satellite cells may respond well to LLLT and help muscle repair. Furthermore the ability of LLLT to reduce inflammation and lessen oxidative stress is also beneficial in cases of muscle fatigue and injury. This review covers the literature relating to LLLT and muscles in both preclinical animal experiments and human clinical studies. Athletes, people with injured muscles, and patients with Duchenne muscular dystrophy may all benefit.
Collaborative targeted minimum loss inference from continuously indexed nuisance parameter estimators (2018)

Suppose that we wish to infer the value of a statistical parameter at a law from which we sample independent observations. Suppose that this parameter is smooth and that we can define two variation-independent, infinite-dimensional features of the law, its so called Q- and G-components (comp.), such that if we estimate them consistently at a fast enough product of rates, then we can build a confidence interval (CI) with a given asymptotic level based on a plain targeted minimum loss estimator (TMLE). The estimators of the Q- and G-comp. would typically be by products of machine learning algorithms. We focus on the case that the machine learning algorithm for the G-comp. is fine-tuned by a real-valued parameter h. Then, a plain TMLE with an h chosen by cross-validation would typically not lend itself to the construction of a CI, because the selection of h would trade-off its empirical bias with something akin to the empirical variance of the estimator of the G-comp. as opposed to that of the TMLE. A collaborative TMLE (C-TMLE) might, however, succeed in achieving the relevant trade-off. We construct a C-TMLE and show that, under high-level empirical processes conditions, and if there exists an oracle h that makes a bulky remainder term asymptotically Gaussian, then the C-TMLE is asymptotically Gaussian hence amenable to building a CI provided that its asymptotic variance can be estimated too. We illustrate the construction and main result with the inference of the average treatment effect, where the Q-comp. consists in a marginal law and a conditional expectation, and the G-comp. is a propensity score (a conditional probability). We also conduct a multi-faceted simulation study to investigate the empirical properties of the collaborative TMLE when the G-comp. is estimated by the LASSO. Here, h is the bound on the l1-norm of the candidate coefficients.
Effects of Bonding Conditions on Mechanical Properties of Spheroida Cast Iron and Structural Carbon Steel Bonded Joint by Liquid Phase Diffusion Bonding Process. (1996)

Spheroidal cast iron has been applied to automotive and machinery parts to reduce their manufacturing cost. But those applications were restricted to machined parts because of its difficulty to be welded with similar and dissimilar material. In this study, the liquid phase diffusion bonding process with thin amorphous Ni-based alloy sheet was applied to spheroidal cast iron(FCD600) and structural carbon steel(S45C) joint, and effects of bonding conditions on mechanical properties of them were investigated. Experimental results are as follows. (1) Tensile strength and fatigue strength of spheroidal cast iron and structural carbon steel bonded joint were improved with increasing in the bonding temperature. (2) Spheroidal cast iron and structural carbon steel bonded joint with optimal condition showed the same mechanical properties as the spheroidal cast iron base
Isolation and identification of cytotoxic compounds from the wood of Pinus resinosa (2008)

Methanol extracts of wood from Pinus resinosa were found to be selectively cytotoxic against human lung carcinoma cells, A549 (IC50 41 +/- 6 microg/mL), human colorectal adenocarcinoma cells, DLD-1 (IC50 47 +/- 4 microg/mL) in comparison with healthy cells, WS1 (IC50 130 +/- 11 microg/mL). Five known compounds were isolated and identified by 1H, 13C NMRspectroscopy and HR-ESI-MS mass spectrometry as, pinosylvin monomethyl ether (1), pinosylvin (2), pinosylvin dimethyl ether (3), pinobanksin (4) and (-)-norachelogenin (5). Compound 4 was isolated for the first time in P. resinosa. The cytotoxicity of compounds 1-5 was evaluated against A549, DLD-1 and WS1. Compound 1 exhibited the strongest cytotoxicity against both tumor cell lines and the healthy cell line with an IC50 of 25 +/- 4 microm for A549, 20 +/- 1 microm for DLD-1 and 34 +/- 3 microm for WS1.
PV-1 is recognized by the PAL-E antibody and forms complexes with NRP-1 (2012)

Pathologische anatomie leiden endothelium (PAL-E) antibody has been used for more than 20 years as a prototype marker for vascular endothelium. The elusive target of this antibody has been claimed to be plasmalemma vesicle-associated protein-1 (PV-1) and neuropilin-1 (NRP-1). Using immunofluorescence, we show that PAL-E, anti-PV-1, anti-NRP-1, and anti-CD31 antibodies show largely identical staining patterns in the vasculature of different tissues. However, PV-1-transfected cells only bind PAL-E and anti-PV-1 antibodies, whereas NRP-1 transfectants stain with anti-NRP-1 antibodies in flow cytometry. Using lysates from tissues and transfected cells, we further confirm that the molecule recognized by PAL-E and anti-PV-1 antibodies is not NRP-1 but PV-1. Nevertheless, coimmunoprecipitation studies unambiguously demonstrate that NRP-1 can form complexes with PV-1. This connects, for the first time, 2 molecules involved in leukocyte trafficking and angiogenesis, thereby opening interesting possibilities for future research in this field.
Therapeutic potential of decoy oligonucleotides strategy in cardiovascular diseases (2003)

Recent progress in molecular biology has provided several new techniques to inhibit target gene expression. In particular, the application of DNA technology, such as an antisense strategy, to regulate the transcription of disease-related genes in vivo has important therapeutic potential. Recently, transfer of cis-element double-stranded oligonucleotides (ODN) (= decoy) has been reported as a new powerful tool in a new class of antigene strategies for gene therapy. Transfer of the double-stranded ODN corresponding to the cis-sequence will result in attenuation of the authentic cis-trans interaction, leading to removal of trans-factors from the endogenous cis-elements with subsequent modulation of gene expression.
Design of embedded systems using data-driven statistical techniques (2006)

A large variety of applications in areas such as pervasive computing, sensor networks, and microbiological systems is driven by the continuously increasing capabilities of modern embedded systems. The synthesis and analysis of embedded systems is a complex task due to the presence of design and operation variability as well as limited predictability of components and application properties. For example, links in wireless ad-hoc networks are often intermittent and properties such as gate delay and power of modern integrated circuits (IC) are subject to manufacturing variability. Traditionally, embedded systems have been addressed in an ad-hoc manner and are mainly addressed using tools that leverage on combinatorial optimization and formal reasoning techniques from computer science, computer engineering, and electrical engineering (e.g. digital signal processing (DSP) and communication). One of the major points of the thesis is that the next generation of embedded systems and integrated circuits will require the use non-parametric statistical techniques (NSTs) to properly capture and predict the behavior, performance, and properties of complex applications and intricate implementation technologies. More importantly, we demonstrate that NSTs can also be a basis for efficient and effective synthesis of modern embedded systems. 
The main goal of this thesis is to address three driver applications (manufacturing variability in integrated circuits, lossy links in wireless ad-hoc networks, and energy efficient sensing of a statistically predictable environment) using a systematic systems of NST-based modeling and optimization techniques. The consistent strategy is the use of collected data from traces of deployed or operational systems to drive both the analysis and realization of an embedded system. The analysis leverages on non-parametric statistical techniques and identifies design insights, tractable and accurate optimization objectives, and serves a basis for fast and realistic simulation. We address the use of statistical techniques at two different levels of embedded system design: during the IC design process, and during the application of embedded system components. At the IC design level, a statistical methodology is used for characterization of three variability issues mainly resultant from manufacturing variability: a priori wire-length estimation, wire-length estimation, and statistical timing analysis. At the distributed systems level, variability is addressed through modeling of lossy wireless link communication, in building a localized routing protocol, modeling of sensor phenomena, and for efficient node deployment.
A High-Spin and Helical Organic Polymer:  Poly{[4-(dianisylaminium)phenyl]acetylene} (2006)

A high-spin polyradical, poly{[4-(dianisylaminium)phenyl]acetylene} 1+, was synthesized as a π-conjugated polymer with an excess of the one-handed helical structure bearing stable aminium cation radicals. [4-(Dianisylamino)phenyl]acetylene (3) was synthesized and polymerized using [Rh(norbornadiene)Cl]2 in (R)-1-phenylethylamine, (S)-1-phenylethylamine, or triethylamine to produce the corresponding poly{[4-(dianisylamino)phenyl]acetylene} 1 (1(R)-PEA, 1(S)-PEA, and 1TEA). The positive and negative Cotton effects were observed at 270−450 nm for the polymers 1(R)-PEA and 1(S)-PEA, indicating that an excess of the one-handed helical polyacetylene backbone was induced by the polymerization using chiral solvents despite the achiral monomer. The oxidation of 1 with NOPF6 gave the corresponding aminium polyradicals 1+, and the circular dichroism (CD) spectrum was observed even after the oxidation of the helical polyradical 1(R)-PEA+. The SQUID and NMR shift measurements indicated a high-spin state of the polyradical at room temperature and a contribution of the well-regulated helical structure to the through-space interaction between the aminium cation radicals.
Preclinical Drug Discovery Research and Training at Vanderbilt (2007)

ADVERTISEMENT RETURN TO ISSUEPREVIn FocusNEXTPreclinical Drug Discovery Research and Training at VanderbiltCraig W. Lindsley†‡*, David Weaver†, Carrie Jones†, Larry Marnett†, and P. Jeffrey Conn†View Author Information† Vanderbilt Institute of Chemical Biology Program in Drug Discovery, Department of Pharmacology, Vanderbilt Medical Center, Nashville, Tennessee 37232‡ Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235*Corresponding author, [email protected]Cite this: ACS Chem. Biol. 2007, 2, 1, 17–20Publication Date (Web):January 19, 2007Publication History Received15 December 2006Accepted18 December 2006Published online19 January 2007Published inissue 1 January 2007https://doi.org/10.1021/cb6004867Copyright © 2007 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views425Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (262 KB) Get e-AlertsSUBJECTS:Assays,Cancer therapy,Drug discovery,Screening assays,Students Get e-Alerts
The effect of an H2-receptor antagonist on food-stimjlated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcers. Comparison with an anticholinergic drug. (1975)

The purpose of the present series of experiments was to measure and compare the effects of an anticholinergic drug (isopropamide) and an antagonist of the histamine H2 receptor (metiamide) on food-stimulated acid secretion. Patients with duodenal ulcers were stimulated by a steak meal, and acid secretion was measured by in vivo intragastric titration. The largest dose of isopropamide that can be taken clinically without producing intolerable side effects (maximum tolerated dose) suppressed food-stimulated acid secretion by 35%. By contrast, metiamide in a 400-mg dose produced no side effects and almost completely abolished food-stimulated acid secretion. A dose-response curve revealed that a 50-mg dose of metiamide was required to suppress food-stimulated acid secretion by 50%. Further studies showed that metiamide and isopropamide are additive in suppressing food-stimulated acid secretion, and that metiamide has no effect on serum gastrin concentration or on gastric emptying.
Optical and scintillation properties of Dy3+:Y3Al5O12 and undoped Y3Al5O12 crystals grown in reduction atmosphere (2012)

Abstract Optical and scintillation properties of a 1.0‐mol% Dy‐doped yttrium aluminium garnet (YAG) grown under N 2 atmosphere and undoped YAG crystals were investigated. Both crystals were grown by the Czochralski process. The one of the undoped YAG crystal was grown in an Ar + H 2 (97:3) reducing atmosphere. Absorption peaks at 352 nm and 366 nm observed in 1.0‐mol% Dy‐doped YAG originated from 4f‐4f transition of Dy 3+ . In addition, the crystal showed sharp emission lines at near 482 nm and 584 nm under 352 nm UV and alpha‐ray excitation. The light output of Dy‐doped YAG was estimated to be approximately 20,000 photons/(5.5‐MeV alpha ray, 241 Am). The scintillation decay time constants for Dy‐doped YAG crystal was around 400 ns and 40 ns. Undoped YAG crystals grown under Ar + H 2 (97:3) atmosphere showed absorption and excitation peak at 370 nm. A 400‐nm emission peak was observed under 370‐nm excitation. The light output of the crystal was also estimated to be 50,000 photons/(5.5‐MeV alpha ray). The scintillation decay time constants of the crystal were around 370 ns and 50 ns. (© 2012 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Twist in the bias dependence of spin torques in magnetic tunnel junctions (2016)

The spin torque in magnetic tunnel junctions possesses two components that both depend on the applied voltage. Here, we develop a method for the accurate extraction of this bias dependence from experiments over large voltage ranges. We study several junctions with different magnetic layer structures of the top electrode. Our results obtained on junctions with symmetric CoFeB electrodes agree well with theoretical calculations. The bias dependences of asymmetric samples, with top electrodes containing NiFe, however, are twisted compared to the quadratic form generally assumed. Our measurements reveal the complexity of spin-torque mechanisms at large bias.
A low power 900 MHz register file (8 ports, 32 words×64 bits) in 1.8 V, 0.25 μm SOI technology (2002)

This paper shows full functionality of a low power 900 MHz dynamic register file (6 Read and 2 Write ports, 32 wordlines/spl times/64 bitlines). Such a register file is designed for bulk silicon technology but is fabricated in 0.25 /spl mu/m Silicon on Insulator (SOI) technology without any body contacts. This paper also proposes a new method to extract the performance gain (which is limited by the tester speed) of a register file in bulk and SOI technology based on internal picoprobe measurements along the critical path. Based on the hardware and simulation data the register file is capable of functioning at 900 MHz for read and write operations in a single cycle. The register file can even function above 1 GHz for read operation. A power reduction of 8-12% is realized for SOI over bulk technology especially at higher frequencies.
Measurement of Haemophilus Influenzae Type A Capsular Polysaccharide Antibodies in Cord Blood Sera (2012)

We measured anti-Haemophilus influenzae type a capsular polysaccharide serum immunoglobulin G antibodies in cord blood sera from Mexican (n = 68) and Chilean mothers (n = 72) by enzyme-linked immunosorbent assay. Measurable antibodies were found in 79.3% of samples. Immunoglobulin G antibodies correlated with serum bactericidal activity (r = 0.66). This enzyme-linked immunosorbent assay can be used for the evaluation of adaptive immune responses to Haemophilus influenzae type a and serosurveillance studies in populations at risk.