gebhart/patrepeval huggingface dataset:
Luminescent hybrid materials based on covalent attachment of Eu(iii)-tris(bipyridinedicarboxylate) in the mesoporous silica host MCM-41 (2014)

A luminescent inorganic-organic hybrid material was synthesized by covalent immobilization of a europium bipyridine carboxylate complex on the inner pore walls of the mesoporous silica host MCM-41 using the grafting method. Guest-host binding was achieved through double functionalization of the host surface with organosilane reagents (trimethylsilyl, TMS, and aminopropyltriethoxysilane, APTES) followed by reaction of the active amino sites of the APTES residue with the ligand 2,2'-bipyridyl-6,6'-dicarboxylic acid. Addition of EuCl3 solution dissolved in ethanol results in the formation of an immobilized complex having the probable formula Eu(L)x(3 ≥ x ≥ 1)(H2O)y, whose detailed photophysical properties were investigated. In the final step, an additional 2,2'-bipyridine-6 monocarboxylic acid ligand was added in an attempt to complete the coordination sphere of the rare earth ion. Each of the synthesis steps was monitored by (1)H, (13)C, and (29)Si solid state NMR spectroscopies, allowing for a quantitative assessment of the progress of the reaction and the influence of the paramagnetic species on the spectra. Based on these data and additional characterizations by chemical analysis, thermogravimetric analysis (TGA), N2 sorption, X-ray diffraction and FT-IR spectroscopy, a comprehensive quantitative picture of the covalent binding and complexation process was developed.
Nonlinear Si-waveguides for mid-infrared comb generation and dual comb spectroscopy at 5 µm (2017)

Dispersive-waves in Si-waveguides extend mid-IR frequency combs to 3–5 µm with negligible added intensity noise through four-wave-mixing. A Si-chip-based dual-comb-spectroscopy system is demonstrated with 40 GHz spectral resolution at 5 µm.
Prediction of nanoparticles-cell association based on corona proteins and physicochemical properties (2015)

Cellular association of nanoparticles (NPs) in biological fluids is affected by proteins adsorbed onto the NP surface, forming a "protein corona", thereby impacting cellular bioactivity. Here we investigate, based on an extensive gold NPs protein corona dataset, the relationships between NP-cell association and protein corona fingerprints (PCFs) as well as NP physicochemical properties. Accordingly, quantitative structure-activity relationships (QSARs) were developed based on both linear and non-linear support vector regression (SVR) models making use of a sequential forward floating selection of descriptors. The SVR model with only 6 serum proteins and zeta potential had higher accuracy (R(2) = 0.895) relative to the linear model (R(2) = 0.850) with 11 PCFs. Considering the initial pool of 148 descriptors, the APOB, A1AT, ANT3, and PLMN serum proteins along with NP zeta potential were identified as most significant to correlating NP-cell association. The present study suggests that QSARs exploration of NP-cell association data, considering the role of both NP protein corona and physicochemical properties, can support the planning and interpretation of toxicity studies and guide the design of NPs for biomedical applications.
Improving the Gene-Regulation Ability of Small RNAs by Scaffold Engineering in Escherichia coli (2013)

Noncoding small RNAs are involved in transcriptional and post-transcriptional gene regulation of target mRNAs by modulating mRNA elongation, stability, or translational efficiency. Many natural trans-encoded small RNAs contain a scaffold that allows binding of the RNA chaperone protein Hfq for conditional gene regulation. Here, we improved the gene regulation abilities of small RNAs by directly fusing the natural Escherichia coli trans-encoded small RNA-derived scaffolds, including Hfq-binding and rho-independent transcription terminator sequences, to the 3' end of the small RNAs that mediate RNA-based gene regulation. As target small RNAs to improve their gene regulation abilities, we selected small RNAs of artificial post-transcriptional riboregulators and transcriptional attenuators. Four different small RNA scaffolds were fused to the riboregulator and attenuator-derived small RNAs. Mutations were introduced into the best small RNA scaffold to improve its gene-regulation ability further. As a result, mutations predicted to stabilize the secondary structures of the small RNA scaffolds dramatically increased its ability to regulate gene expression of both the post-transcriptional riboregulator and transcriptional attenuator systems. We believe our engineered small RNA scaffolds are applicable to other RNA regulators for improving regulatory activity, and engineered small RNA scaffolds may present a valuable strategy to regulate target gene expression strongly.
Edible Insects’ Transformation for Feed and Food Uses: An Overview of Current Insights and Future Developments in the Field (2022)

The integration of insect-derived extracts in feed and food products has become a field of growing interest in recent years. In this review, we collect different studies carried out on edible insects’ transformation processes and focus on the various treatment operations, extraction technologies, and solvents used in different processing steps. We include an overview of current insights into the different steps of the transformation process: insect reception, killing methods, pretreatments, storage, delipidation, protein extraction, as well as chitin and chitosan extraction. Finally, we reflect on the most important future challenges of this sector.
Machine Learning: A Novel Approach to Predicting Slope Instabilities (2018)

Geomechanical analysis plays a major role in providing a safe working environment in an active mine. Geomechanical analysis includes but is not limited to providing active monitoring of pit walls and predicting slope failures. During the analysis of a slope failure, it is essential to provide a safe prediction, that is, a predicted time of failure prior to the actual failure. Modern-day monitoring technology is a powerful tool used to obtain the time and deformation data used to predict the time of slope failure. This research aims to demonstrate the use of machine learning (ML) to predict the time of slope failures. Twenty-two datasets of past failures collected from radar monitoring systems were utilized in this study. A two-layer feed-forward prediction network was used to make multistep predictions into the future. The results show an 86% improvement in the predicted values compared to the inverse velocity (IV) method. Eighty-two percent of the failure predictions made using ML method fell in the safe zone. While 18% of the predictions were in the unsafe zone, all the unsafe predictions were within five minutes of the actual failure time, all practical purposes making the entire set of predictions safe and reliable.
Advancing cancer target discovery through vector-mediated RNAi. (2006)

SY22-01 We have optimized high throughput lentivirus-mediated delivery of short hairpin RNAs (shRNAs) for use in screens for novel cancer gene targets. We are using this approach to identify genes whose silencing enhances the effects of existing chemotherapeutic compounds. The hits from our screens are useful in two key ways: First, these genes, or members of their respective pathways, may serve as ideal targets for small molecule inhibitors that could be administered in combination with lower doses of standard chemotherapies. Second, these hits may provide better predictions of patient response to the treatment studied. Along with screening for novel drug targets, we are using vector-mediated RNAi to explore cancer gene networks through microarray profiling. Previously, we reported that transfection of small interfering RNAs (siRNAs) can result in the cleavage of unintended targets. Although less prevalent, we find that shRNAs can also result in silencing of transcripts other than that for which the shRNA was designed. We see that such off-target mRNAs are enriched for transcripts containing the shRNA antisense strand equivalents of microRNA seed-region hexamers. This observation suggests that, like siRNAs, shRNAs are not exquisitely specific, and very short regions of homology within a core shRNA sequence are sufficient to produce undesired effects. These results emphasize the need to use multiple RNAi sequences to ensure that observed phenotypes correspond directly to silencing of intended target genes. Because of this, we have incorporated the use of multiple shRNAs into our screening platform.
<title>Modeling and design of waveguide-coupled single-mode microring resonators</title> (1998)

We discuss a first-order design tool for waveguide-coupled microring resonators based on an approximate solution of the wave propagation in a microring waveguide with micron-size radius of curvature and a large lateral index contrast. The model makes use of the conformal transformation method and a linear approximation of the refractive index profile, and takes into account the effect of waveguide thickness, dispersion, and diffraction. Based on this model, we develop general design rules for the major physical characteristics of a waveguide-coupled microring resonator, including the resonance wavelength, the free spectral range, the coupling ratio, the bending radiation loss and the substrate leakage loss. In addition, the physical model provides insights into alternative coupling designs that significantly increase the coupling length and reduce or eliminate the dependence on a narrow air gap in the waveguide-coupled microring resonator. We present two examples, one using a phase-matching parallel waveguide with a smaller width than the ring waveguide, and the other using a vertical coupling structure.
New Greenbug Resistant Sources in Winter Barley,Hordeum vulgare (2017)

Greenbug, Schizaphis graminum (Rondani), is a chronic problem for small grains on the Southern Plains. Central to the pest status of greenbug is the occurrence of resistance-breaking biotypes. Rsg1 and Rsg2 are the only two genes for resistance of barley, Hordeum vulgare L., to greenbug. Only Rsg1 has been deployed in cultivars. Discovery of new resistant genes is essential as biotypes continue to shift. Five winter barley accessions, PI 499276, PI 565657, PI 566459, CI 2458, and PI 565676, ‘Post 90’ (Rsg1), STARS 1501B (Rsg2), and susceptible ‘Schuyler’, were evaluated in isolated cages against 14 greenbug biotypes: B, C, E, F, H, I, TX1, WY4 A, WY4 B, WY10 MC, WY10 B, WY12 MC, WY81, and WY86. Damage scores were based on a scale of 1–9 for chlorosis (1 was resistant and 9 was dead). Damage means were classified as R or S and used to construct a response matrix which indicated unique resistance genes in four lines. These new sources have potential to reduce vulnerability of barley to future outbreaks of greenbug.
DFT study of an unusual proton-relay role for Cp* in hydrogen evolution catalysis (2016)

Understanding mechanisms of the hydrogen evolution reaction (HER) is crucial to designing efficient catalysts for the prodn.&#13;\nof solar fuels. Cp*Rh(bpy) (Cp* = η^5- pentamethylcyclopentadienyl; bpy = κ^2-2,2'- bipyridyl) generates hydrogen in the&#13;\npresence of acid. However, the nature of the elementary steps leading to H-H formation has not been clear, as chem.&#13;\ncharacterization of intermediates in the catalytic reaction has been difficult to obtain. Here, we present a joint exptl.-&#13;\ncomputational study that addresses this challenge. D. functional theory (DFT) calcns. demonstrate that the catalyst first&#13;\nundergoes a 2e- redn. to form a Rh^I complex. Subsequently, in presence of acid, the Rh complex undergoes protonation at the&#13;\nCp* ligand to form a complex bearing an [η^4-Cp*H] ligand, preserving the RhI center. DFT calcns. show that this complex is&#13;\n6.8 kcal /mol more stable than the analogous Rh^(III) hydride. Following the formation of this intermediate, a second protonation&#13;\ncan be carried out which results in evolution of hydrogen and restoration of η^5-Cp*. To the best of our knowledge, these&#13;\nresults are among the first to show Cp* can serve as a proton relay in HER. New DFT results on the full mechanism for this&#13;\ncompd. will be presented, and predictions of possible improvements to the catalyst will be discussed in light of the newly&#13;\ncharacterized intermediate.
Model of coating and drying process for flat polymer film fabrication (2002)

The coating procedure of polymer solutions by the scanning technique is developed for LSI technologies at the next generation, where a polymer solution as resists and inter-layer dielectric films is coated on a flat substrate, and then only the solvent is vaporized and removed, and finally the thin film is remaining there. In case of applying to the photo-lithography process, scan coating and its drying processes work together for astonishing flatness in 1% fluctuation range. When the coated polymer solution is dried under reduced pressure or vacuum, the thickness distribution of the resultant film should be accurately prospected and controlled by parameters. The film thickness is generally thicker at the edge and thinner inside from there than the average thickness. A typical thickness profile of a resist film is shown in Figure 1 . The phenomena are always observed, but have not been analyzed numerically. In this paper, we report a numerical model of the drying process of liquid film including polymers and give the essential parameters to the coating and drying processes. The parameters are focused on a vaporization rate, diffusion coefficients, coated solution thickness and intrinsic viscosity, which were calculated by simplified dynamical models of Langmuir's vaporization rate equation and Einstein relation at complex polymer solutions.
An exclusion map of Marfan syndrome. (1990)

The combined genetic data between the Marfan syndrome and 75 informative loci on 18 autosomes were used to construct an exclusion map for this disorder. Data are also presented for a further two unmapped markers. The most likely location of the Marfan syndrome gene is highlighted and all the unexcluded areas of the genome are displayed in a graphical form. This exclusion map shows that almost 75% of the genome has been excluded as a likely location for the Marfan syndrome gene in the majority of the families studied. Apart from chromosomes 8, 13, 21, and 22, for which no data were available, other regions not excluded yet include 5p, 6p, 9p, 10p, 12p, 15, 17p, 18, and 20p. Future linkage analysis using markers located in the highlighted regions should facilitate the identification of the site of the Marfan syndrome gene.
Open mind common sense: crowd-sourcing for common sense (2010)

Open Mind Common Sense (OMCS) is a freely available crowd-sourced knowledge base of natural language statements about the world. The goal of Open Mind Common Sense is to provide intuition to AI systems and applications by giving them access to a broad collection of basic information and the computational tools to work with this data. For our system demo, we will be presenting three aspects of the OMCS project: the OMCS knowledge base, the Concept-Net semantic network (Liu and Singh 2004) (Havasi, Speer, and Alonso 2007), and the AnalogySpace algorithm (Speer, Havasi, and Lieberman 2008) which deals well with noisy, user-contributed data.
Small peptide inhibitors of smooth muscle myosin light chain kinase (1990)

The pentapeptide Ser-Asn-Val-Phe-Ala-OBzl has been identified as the smallest inhibitory peptide of myosin light chain kinase (MLCK) derived from the primary sequence of the light chain phosphorylation site. The specific contributions of individual amino acid side chains and backbone elements of this pentapeptide toward the stabilization of the enzyme-inhibitor (E-I) complex have been evaluated. The potency of these peptides as inhibitors of MLCK has been enhanced by the incorporation of synthetic nonnatural amino acids into the sequence. Finally, it has been demonstrated that these peptide sequences could be converted into pseudopeptides with synthetic nonpeptide subunits designed to mimic peptide bonds, and that certain pseudopeptides retained the high-affinity inhibition of the parent pentapeptides.
Supplementary Figure 7 from HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That Is Critical for Tumorigenesis (2023)

Supplementary Figure 7 from HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That Is Critical for Tumorigenesis
Bacterial adhesion force quantification by fluidic force microscopy (2015)

Quantification of detachment forces between bacteria and substrates facilitates the understanding of the bacterial adhesion process that affects cell physiology and survival. Here, we present a method that allows for serial, single bacterial cell force spectroscopy by combining the force control of atomic force microscopy with microfluidics. Reversible bacterial cell immobilization under physiological conditions on the pyramidal tip of a microchanneled cantilever is achieved by underpressure. Using the fluidic force microscopy technology (FluidFM), we achieve immobilization forces greater than those of state-of-the-art cell-cantilever binding as demonstrated by the detachment of Escherichia coli from polydopamine with recorded forces between 4 and 8 nN for many cells. The contact time and setpoint dependence of the adhesion forces of E. coli and Streptococcus pyogenes, as well as the sequential detachment of bacteria out of a chain, are shown, revealing distinct force patterns in the detachment curves. This study demonstrates the potential of the FluidFM technology for quantitative bacterial adhesion measurements of cell-substrate and cell-cell interactions that are relevant in biofilms and infection biology.
A New Murine Monoclonal Antibody Against Human Hepatoma (1991)

A murine monoclonal antibody (MAb 336) reactive with human hepatocellular carcinoma has been raised after immunizing BALB/c mice with whole HepG2 cells. MAb 336 (IgG1) was reactive with HepG2 (whole cells and membrane fractions), but not normal liver or peripheral blood cells. Immunohistological studies indicated that 12/16 hepatocellular carcinoma and 6/11 cirrhotic livers expressed MAb 336-associated antigen, and most normal human tissues and tissues derived from other cancers were unstained. Direct and competitive binding assays ruled out the possibility that this MAb reacts with alpha-fetoprotein, carcinoembryonic antigen, or ferritin. Western blot analysis indicated that MAb 336 reacts with an antigen of approximately 30,000 daltons. This MAb may be potentially useful for studying antigenic expression in hepatocellular carcinoma and as a targeting agent for radioimmunodetection and immunoconjugate therapy.
Induction Electrohydrodynamic Pump in a Vertical Configuration: Part 2—Experimental Study (1989)

An induction electrohydrodynamic (EHD) pump in axisymmetric, vertical configuration was designed and built. The flow rates were measured for various temperature profiles and several values of frequency, voltage, wavelength, and electric conductivity. The experimental data are generally in good agreement with the theoretical model presented in Part 1. With the present apparatus at relatively low voltages, velocities four times higher than natural circulation velocity are easily obtained. The external pressure load and entrance temperature profile play important roles on the operation of the pump and must be considered carefully in the design.
Quick Portable Electrochemical Sensing Platform to Detect Al3+ Content in Our Dietary Fruit Juices (2021)

Aluminum is one of the most widely distributed elements (7.5%) of the earth crust. The current research interest in the aluminum content in our foods and diets are related to the concerns about the possible association of excessive intake and/or elevated tissue levels of this element and linked with various disorders viz. Alzheimer's, Dialysis encephalopathy/dementia, bone disorder. Aluminum (Al) is present in our daily food naturally, but mostly in elevated level through the various food additives, by the use Al cookware, storage canes and Al wrappings. The migration of Al is known to increase with the acidity (pH of the food), duration of storage, and presence of salts and organic acids. As it is found commonly in our daily food products and it may not be the reach of every common people to have sophisticated laboratory test to understand the Aluminum content in the daily food products. Herein, we have developed a quick portable electrochemical platform to measure the threshold Al content in the readily available food samples mostly canned foods (juices having the pH acidic (pH 3.5-5.5). For that, we used Pd/C (palladium black catalysts) modified Au screen- printed electrode. The activity of the catalyst influenced by the added Al 3+ content was analyzed using Electrochemical impedance spectroscopy. The calibrated dose rate (CDR) is obtained as a function of the change in Z mod (Ω) value from the Bode plot vs the concentration of added Al 3+ in buffer of different pH in the concentration ranging 0.5µg/mL to 1mg/mL. The sensors were tested for real canned juice samples. Such method can be an easy and quick qualitative testing procedure for Aluminum poisoning in our everyday food products Figure 1
(E)-3-(Trimethylsilyl)-2-propen-1-ol. An improved preparation (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT(E)-3-(Trimethylsilyl)-2-propen-1-ol. An improved preparationS. E. Denmark and T. K. JonesCite this: J. Org. Chem. 1982, 47, 23, 4595–4597Publication Date (Print):November 1, 1982Publication History Published online1 May 2002Published inissue 1 November 1982https://pubs.acs.org/doi/10.1021/jo00144a044https://doi.org/10.1021/jo00144a044research-articleACS PublicationsRequest reuse permissionsArticle Views2468Altmetric-Citations180LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts