gebhart/patrepeval huggingface dataset:
A Distributed Augmented Reality System for Medical Training and\n Simulation (2018)

Augmented Reality (AR) systems describe the class of systems that use\ncomputers to overlay virtual information on the real world. AR environments\nallow the development of promising tools in several application domains. In\nmedical training and simulation the learning potential of AR is significantly\namplified by the capability of the system to present 3D medical models in\nreal-time at remote locations. Furthermore the simulation applicability is\nbroadened by the use of real-time deformable medical models. This work presents\na distributed medical training prototype designed to train medical\npractitioners' hand-eye coordination when performing endotracheal intubations.\nThe system we present accomplishes this task with the help of AR paradigms. An\nextension of this prototype to medical simulations by employing deformable\nmedical models is possible. The shared state maintenance of the collaborative\nAR environment is assured through a novel adaptive synchronization algorithm\n(ASA) that increases the sense of presence among participants and facilitates\ntheir interactivity in spite of infrastructure delays. The system will allow\nparamedics, pre-hospital personnel, and students to practice their skills\nwithout touching a real patient and will provide them with the visual feedback\nthey could not otherwise obtain. Such a distributed AR training tool has the\npotential to: allow an instructor to simultaneously train local and remotely\nlocated students and, allow students to actually "see" the internal anatomy and\ntherefore better understand their actions on a human patient simulator (HPS).\n
Initial chemical events caused by mutagenic heteroaromatic amines. (1985)

Initial chemical events caused by mutagenic heteroaromatic amines are discussed. 2-Amino-6-methyldipyrido [1, 2-a : 3', 2'-d] imidazole (Glu-P-1) and 3-amino-1-methyl-5H-pyrido [4, 3-b] indole (Trp-P-2) are potent mutagens isolated from pyrolysates of glutamic acid and tryptophan, respectively. These carcinogens are N-hydroxylated with microsomes to give the corresponding hydroxylamines. These hydroxylamines are O-acylated with cytosol to give the corresponding N-acyloxy derivatives, which react with DNA. The structures of the modified nucleic acid bases with Glu-P-1 and Trp-P-2 were determined to be 2-(guanin-8-yl) amino-6-methyldipyrido [1, 2-a : 3', 2'-d] imidazole (Gua-Glu-P-1) and 3-(guanin-8-yl) amino-1-methyl-5H-pyrido [4, 3-b] indole (Gua-Trp-P-2), respectively. Syntheses of these heteroaromatic amines, these modified nucleic acid bases and metabolically activated hydroxylamines are described. Reactions of model compounds of the ultimate forms of these heteroaromatic amines with nucleic acids were investigated. Thus, the pathway of the chemical modification of DNA with Glu-P-1 and with Trp-P-2 were established chemically. In addition, the same chemical modification of DNA with Glu-P-1 and with Trp-P-2 were observed in vivo (rats). In the pathway, intercalation of these heteroaromatic amines is an important factor which makes the covalent reaction facile and determines the mutagenic activity. Intercalative ability of Glu-P's were established by physical methods. The chemical modification of DNA is quite specific to the 8-position of guanine moiety, and the guanine moieties in G-C rich regions are preferentially modified. The established pathway of chemical modification of DNA with Glu-P-1 and with Trp-P-2 provides a fundamental standpoint in the study on chemical carcinogenesis caused by these heteroaromatic amines.
Epidemiology and Outcomes of Candidemia in 2019 Patients: Data from the Prospective Antifungal Therapy Alliance Registry (2009)

The epidemiology and choice of therapy for candidemia are rapidly changing. Additional study is warranted to differentiate host factors and differences in virulence among Candida species and to determine the best therapeutic regimen.
Influenza vaccine response in community-dwelling German prefrail and frail individuals (2017)

Clinicaltrials.gov NCT02262091 (October 8, 2013).
Visible light active nanofibrous membrane for antibacterial wound dressing (2018)

Chronic wound infections, especially due to the emergence of multidrug resistance in bacteria, require the urgent development of alternative antibacterial therapies. Here, we developed a new class of hydrogel nanofibrous membranes that show visible light-induced disinfection. The presented photocatalytic disinfection is based on the generation of reactive singlet oxygen from a conjugated microporous polymer upon visible light irradiation. Therefore, sustained protection of the wound area can be provided in the presence of visible light. Fabrication of the photoactive wound dressing consists of first synthesizing photoactive conjugated microporous polymer nanoparticles by miniemulsion polymerization and subsequently embedding the nanoparticles in polyvinyl alcohol hydrogel nanofibers by colloid-electrospinning. The fibers were then crosslinked in glutaraldehyde/HCl vapor to be water-insoluble. This nanoparticle-in-nanofiber structure allows for a flexible combination of the properties of the nanoparticles and supporting nanofibers. The disinfecting properties of the membranes were evaluated with the inactivation of Escherichia coli K-12 and Bacillus subtilis as model systems of Gram-negative and Gram-positive bacteria, as well as the inhibition of biofilm growth under irradiation of visible light. Cytotoxicity tests on fibroblast cells revealed a high cytocompatibility of the membranes. Furthermore, the good mechanical properties of the membranes allow for their facile removal after use and prevent the leakage of the embedded nanoparticles into the wound, making the photoactive hydrogel membranes a promising candidate for active wound dressing materials.
Efecto de una dieta con bajo aporte de selenio sobre la respuesta inmune a la vacuna Brucella abortus Cepa RB51 en vacas lecheras (2006)

The effect of a diet with a low selenium (Se) content on the immune response to Brucella abortus Strain RB51 vaccine in dairy cows and in their serum inmunoglobulin concentrations was studied.Twelve pregnant Friesian cows (7 to 8 months) were randomly allocated into two homogeneous groups of six animals each.Animals were maintained during 6 months in individual cubicles with water ad libitum and a diet based on grass hay with a low Se content (0.02 ppm base on dry matter) and nutritionally balanced for other nutrients.One group was maintained only with the low Se diet (Se-D) and the other group (Se-S) was treated with barium selenate (1 mg Se/kg sc) 45 days before calving.All off the cows were immunized with Brucella abortus RB51 vaccine during the fourth month of the experiment.Blood samples were obtained before supplementation and thereafter every 15 days for determination of the GSH-Px activity in erythrocytes.Serum IgG, IgM and IgA concentrations were determined by the inmunodiffusion radial method.Anti Brucella abortus antibodies were determined by an ELISA technique.Cellular immune response to Brucella abortus antigen was evaluated by intradermic reaction test and histological analysis.Erythrocyte GSP-Px activity in the Se-D group decreased to deficient values (<60 U/g Hb) on day 150 of the experiment, while that in the Se-S group increased and remained within adequate values (>130 U/g Hb) during the entire experimental period.Serum concentrations of IgG, IgM and IgA were similar in both groups of cows and also there were no differences (P>0.05) in the humoral and cellular immune responses to RB51 vaccine.These results suggest that the use of a diet with a low Se content does not affect the humoral and cellular response to RB51 vaccine.
Effect of Delayed Antimicrobial Therapy as a Model of Infection Related Sepsis (2002)

Effect of Delayed Antimicrobial Therapy as a Model of Infection Related Sepsis Get access D. Peng, MD, PhD, D. Peng, MD, PhD 1US Army Institute of Surgical Research, Fort Sam Houston, TX Search for other works by this author on: Oxford Academic Google Scholar A. T. McManus, PhD A. T. McManus, PhD 1US Army Institute of Surgical Research, Fort Sam Houston, TX Search for other works by this author on: Oxford Academic Google Scholar The Journal of Burn Care & Rehabilitation, Volume 23, Issue suppl_2, March-April 2002, Page S118, https://doi.org/10.1097/00004630-200203002-00151 Published: 01 March 2002
Method for removal of carbon dioxide from a carrier liquid (2023)

A method for removing carbon dioxide from a carrier liquid using a heat exchanger. A carrier liquid, containing carbon dioxide, is heated through the heat exchanger, causing the carbon dioxide to vaporize. The carrier liquid and the carbon dioxide gas pass to a liquid removal vessel. The carrier liquid is removed and the carbon dioxide gas is compressed. The compressed carbon dioxide gas is provided to the heat exchanger, cooling the carbon dioxide gas opposite the carrier liquid, producing a carbon dioxide liquid.
Involvement of C3a and C5a in Interleukin-8 Secretion by Human Polymorphonuclear Cells in Response to Capsular Material ofCryptococcus neoformans (1998)

In a previous paper we demonstrated that human polymorphonuclear cells (PMN) in the presence of normal human serum (NHS) secrete proinflammatory cytokines in response to Cryptococcus neoformans or its major capsular component, glucuronoxylomannan (GXM). The hypothesis that activation of the complement system could be responsible for the observed phenomenon is supported by the fact that encapsulated and acapsular C. neoformans isolates are activators of the complement system and, in particular, large encapsulated isolates are powerful activators. In the present study we demonstrate that (i) interleukin-8 (IL-8) release in response to acapsular or encapsulated strains of C. neoformans is significantly reduced in the presence of heat-inactivated serum rather than NHS and is completely abrogated in the absence of human serum; (ii) GXM-induced IL-8 release is strictly dependent on the presence of NHS, is inhibited by specific antibodies to either C3a and C5 complement components, and is completely abrogated by the combined use of these antibodies; (iii) the addition of purified C3a and C5a directly stimulates IL-8 release by PMN; and (iv) monoclonal antibody to GXM in combination with GXM or encapsulated C. neoformans potentiates IL-8 release by PMN. These data shed light on the mechanism involved in GXM-induced IL-8 secretion by PMN, provide an additional potential role for complement in the control of C. neoformans infections, and suggest a complex interplay between the complement system, humoral immunity, and cytokine regulation.
Novel Monoclonal Antibodies for Studies of Human and Rhesus Macaque Secretory Component and Human J-Chain (2016)

Immunoglobulin A (IgA) antibodies exist in monomeric, dimeric, and secretory forms. Dimerization of IgA depends on a 15-kD polypeptide termed "joining (J) chain," which is also part of the binding site for an epithelial glycoprotein called "secretory component (SC)," whether this after apical cleavage on secretory epithelia is ligand bound in secretory IgA (SIgA) or in a free form. Uncleaved membrane SC, also called the "polymeric Ig receptor," is thus crucial for transcytotic export of SIgA to mucosal surfaces, where it interacts with and modulates commensal bacteria and mediates protective immune responses against exogenous pathogens. To evaluate different forms of IgA, we have produced mouse monoclonal antibodies (MAbs) against human J-chain and free SC. We found that J-chain MAb 9A8 and SC MAb 9H7 identified human dimeric IgA and SIgA in enzyme-linked immunoassay and western blot analysis, as well as functioning in immunohistochemistry to identify cytoplasmic IgA of intestinal lamina propria plasmablasts/plasma cells and crypt epithelium of distal human intestine. Finally, we demonstrated that SC MAb 9H7 cross-reacted with rhesus macaque SIgA. These novel reagents should be of use in the study of the biology of various forms of IgA in humans and SIgA in macaques, as well as in monitoring the production and/or isolation of these forms of IgA.
Compartmentalized Connexin 43 S -Nitrosylation/Denitrosylation Regulates Heterocellular Communication in the Vessel Wall (2010)

This study provides evidence for compartmentalized S-nitrosylation/denitrosylation in the regulation of smooth muscle cell to endothelial cell communication.
Thin Films of Fully Noble Metal-Free POM@MOF for Photocatalytic Water Oxidation (2019)

<b>P<sub>2</sub>W<sub>18</sub>Co<sub>4</sub>@MOF-545</b>, which contains the sandwich-type polyoxometalate (POM) [(PW<sub>9</sub>O<sub>34</sub>)<sub>2</sub>Co<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>]<sup>10-</sup> (<b>P<sub>2</sub>W<sub>18</sub>Co<sub>4</sub></b>) immobilized in the porphyrinic metal-organic framework (MOF), MOF-545, is a "three-in-one" (porosity + light capture + catalysis) heterogeneous photosystem for the oxygen-evolution reaction (OER). Thin films of this composite were synthesized on transparent and conductive indium tin oxide (ITO) supports using electrophoretic (EP) or drop-casting (DC) methods, thus providing easy-to-use devices. Their electro- and photocatalytic activities for OER were investigated. Remarkably, both types of films exhibit higher turnover numbers (TONs) than the original bulk material previously studied as a suspension for the photocatalytic OER, with TONs after 2 h equal to 1600 and 403 for DC and EP films, respectively, compared to 70 for the suspension. This difference of catalytic activities is related to the proportion of efficiently illuminated crystallites, whereby a DC thin film offers the largest proportion of POM@MOF crystallites exposed to light due to its lower thickness when compared to an EP film or crystals in suspension. Such devices can be easily recycled by simply removing them from the reaction medium and washing them before reuse. The films were fully characterized with extended X-ray absorption fine structure (EXAFS) and X-ray absorption near edge structure (XANES) spectroscopies, Raman, scanning electron microscopy, and electrochemistry before and after catalysis. The combination of all of these techniques shows the stability of both the POM and the MOF within the composite upon water-oxidation reaction.
Sub-milliwatt coherent microcomb generation (2022)

We demonstrate coherent microcomb generation based on an AlGaAs-on-insulator microresonator operating at sub-milliwatt pump power regime, that can be directly driven by on-chip laser.
ATHLETE - EQUIPMENT INTERACTION (2016)

The purpose of this research is to understand how to match an athlete to a piece of athletic equipment. Individual athlete characteristics require specific equipment parameters to optimize performance. Similarly individual movement patterns can be matched to equipment characteristics to help prevent injury. The athlete and equipment form a biomechanical system influenced by biomechanical principles such as the force-length and force-velocity relationship of skeletal muscle. By understanding the athlete-equipment interaction, sport equipment can be tuned to individual athletes to maximize performance and minimize injury.
Fractional photothermolysis for the treatment of facial wrinkles – searching for optimal treatment parameters in a randomized study in the split‐face design (2012)

FP with higher energy per MTZ at constant total energy input is more effective in the treatment of facial wrinkles than lower energy. The gain in effectiveness is, nonetheless, accompanied by an increase in adverse reactions. The treating physician may use this information to adjust treatment to the preferences of the individual patient.
Thermal agglomeration kinetics of low nuclearity molybdenum clusters in liquid poly(dimethylsiloxane-co-methylphenylsiloxane): stability of metal clusters in arene containing liquid reaction media. Part 3 (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal agglomeration kinetics of low nuclearity molybdenum clusters in liquid poly(dimethylsiloxane-co-methylphenylsiloxane): stability of metal clusters in arene containing liquid reaction media. Part 3Mark P. Andrews and Geoffrey A. OzinCite this: J. Phys. Chem. 1986, 90, 15, 3353–3359Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://pubs.acs.org/doi/10.1021/j100406a010https://doi.org/10.1021/j100406a010research-articleACS PublicationsRequest reuse permissionsArticle Views35Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Stroboscopic testing of LSIs with low voltage scanning electron microscope (1985)

SUMMARY A stroboscopic scanning‐ electron microscope (SEM) with 1 keV electrons has been developed to analyse the internal voltage waveforms in very large scale integrated circuits (VLSIs). A field emission gun and a short focal length objective lens are used to obtain a fine probe. Secondary electrons returning up through the objective lens are detected and analysed by a hemispherical retarding field energy analyser. The working distance of the objective lens is 3 mm, and a small stable probe of 0.1 μm in diameter with 1.6 nA in beam current is obtained. The linearity of the potential measurement is fairly good in spite of analysing secondary electrons which pass through the magnetic field. A minimum time resolution of 500 ps as well as a voltage resolution of 50 mV can be measured. This stroboscopic SEM has been successfully applied to evaluation of high speed waveforms in a ECL‐4K bit bipolar RAM.
Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles. (2007)

Abstract Activating mutations in the juxtamembrane domain or the activation loop of the receptor tyrosine kinase FLT3 occur in many cases of acute myeloid leukemia (AML), but it is not known whether genomic alterations outside these regions contribute to leukemogenesis. High-throughput DNA sequence analysis has provided insights into the mutational profiles of various cancers and represents a promising strategy for the identification of novel therapeutic targets. However, recognizing the subset of genomic alterations that are functionally relevant has proven difficult. We used a high-throughput platform to interrogate the entire FLT3 coding sequence in a cohort of 222 adult AML patients without known FLT3 mutations and experimentally tested the functional consequences of each candidate leukemogenic allele by exogenous expression in BaF3 cells. DNA sequencing detected nine non-synonymous sequence variants in six exons that were not known single-nucleotide polymorphisms. Functional assessment of these alleles identified four novel activating mutations in the extracellular domain, the juxtamembrane domain, and the activation loop that induced constitutive kinase activity, differentially activated downstream signaling pathways, and conferred varying sensitivity to pharmacologic FLT3 inhibition. In contrast, the remaining five alleles, including mutations in highly conserved, key functional domains of FLT3, were not associated with increased kinase activity and aberrant signal transduction. These findings support the concept that acquired mutations in cancer may not contribute to malignant transformation, and underscore the importance of functional validation of candidate alleles discovered using high-throughput genomic screens, to distinguish between ‘driver’ mutations underlying cancer development, and biologically neutral ‘passenger’ alterations.
From Evaluating to Forecasting Performance: How to Turn Information Retrieval, Natural Language Processing and Recommender Systems into Predictive Sciences (Dagstuhl Perspectives Workshop 17442) (2018)

We describe the state-of-the-art in performance modeling and prediction for Information Retrieval (IR), Natural Language Processing (NLP) and Recommender Systems (RecSys) along with its shortcomings and strengths. We present a framework for further research, identifying five major problem areas: understanding measures, performance analysis, making underlying assumptions explicit, identifying application features determining performance, and the development of prediction models describing the relationship between assumptions, features and resulting performance.
Effects of Reynolds Number and Heat Transfer on Scaling of a Centrifugal Compressor Impeller (2010)

In this paper, the influence of Reynolds number and heat transfer on scaling of a small scale centrifugal compressor impeller was investigated. The flow solver EURANUS, integrated in the FINE/Turbo interface, was used in the numerical simulation. With the application of the similarity principle, the baseline impeller was scaled with a factor of 1/5 and 5 respectively. Using the baseline impeller as reference, an exponential relation between efficiency loss and Reynolds number was used in this study. By comparing Reynolds exponent n of the scaled-up and the scaled-down impellers under adiabatic wall condition, the effect of Reynolds number on scaling of this small scale impeller was studied. The effect of heat transfer was investigated by comparing the results under two different wall conditions (isothermal and adiabatic). This work provides general guidelines for performing scaling designs for small scale centrifugal impellers.
Room-Temperature InAs/InP Quantum-Dot Photonic Crystal Microlasers Using Cavity-Confined Slow Light (2007)

We achieved room temperature laser operation, around 1.5 mum, with a single layer of InAs/InP quantum dots in a photonic crystal structure using confined slow light. The lasing threshold is a few hundred muW.