gebhart/patrepeval huggingface dataset:
A patient-specific computational model of hypoxia-modulated radiation resistance in glioblastoma using 18 F-FMISO-PET (2014)

Glioblastoma multiforme (GBM) is a highly invasive primary brain tumour that has poor prognosis despite aggressive treatment. A hallmark of these tumours is diffuse invasion into the surrounding brain, necessitating a multi-modal treatment approach, including surgery, radiation and chemotherapy. We have previously demonstrated the ability of our model to predict radiographic response immediately following radiation therapy in individual GBM patients using a simplified geometry of the brain and theoretical radiation dose. Using only two pre-treatment magnetic resonance imaging scans, we calculate net rates of proliferation and invasion as well as radiation sensitivity for a patient's disease. Here, we present the application of our clinically targeted modelling approach to a single glioblastoma patient as a demonstration of our method. We apply our model in the full three-dimensional architecture of the brain to quantify the effects of regional resistance to radiation owing to hypoxia in vivo determined by [(18)F]-fluoromisonidazole positron emission tomography (FMISO-PET) and the patient-specific three-dimensional radiation treatment plan. Incorporation of hypoxia into our model with FMISO-PET increases the model-data agreement by an order of magnitude. This improvement was robust to our definition of hypoxia or the degree of radiation resistance quantified with the FMISO-PET image and our computational model, respectively. This work demonstrates a useful application of patient-specific modelling in personalized medicine and how mathematical modelling has the potential to unify multi-modality imaging and radiation treatment planning.
Liability for autonomous agent design (1998)

Article Liability for autonomous agent design Share on Authors: Carey Heckman Stanford Law School, Crown Quadrangle, Standford, CA Stanford Law School, Crown Quadrangle, Standford, CAView Profile , Jacob O. Wobbrock Stanford Symbolic Systems Program, PO Box 5264, Stanford, CA Stanford Symbolic Systems Program, PO Box 5264, Stanford, CAView Profile Authors Info & Claims AGENTS '98: Proceedings of the second international conference on Autonomous agentsMay 1998 Pages 392–399https://doi.org/10.1145/280765.280869Published:01 May 1998 12citation302DownloadsMetricsTotal Citations12Total Downloads302Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
User Customizable Logic Paper (UCLP) with organic sea-of-transmission-gates (SOTG) architecture and ink-jet printed interconnects (2010)

With recent advances in printable large-area electronics [1, 2], it is not a fantasy anymore to print macroscopic-level organic ICs by ink-jet printers. To prototype the organic circuits for the higher integration level, we propose User Customizable Logic Paper (UCLP). The UCLP can be easily customized by the user and operated in a speed for educational purposes that one can see how the circuit operates with one's naked eyes. With an ordinary ink-jet printer, one can utilize UCLP to make one's own circuit by printing customized interconnects on the prefabricated array of organic transistors. This paper demonstrates the feasibility and in-field customizability of UCLP with Sea-of Transmission-Gates (SOTG) of organic CMOS transistors. This type of technology will provide ways to add programmability for ICs used in large-area electronics such as smart flexible displays, power transmission sheets, and electronic skin for robots.
Transitive Statistical Sensor Error Characterization and Calibration (2006)

Calibration is the process of identifying and correcting for the systematic bias component of the error in the sensor measurements. On-line and in-field sensor measurement calibration is particularly crucial since manual calibration is expensive and sometimes infeasible. We have developed an on-line and in-field error modeling technique, which is a generalization of the calibration problem, that relies on a small number of inaccurate sensors with known error distributions to develop error models for the deployed in-field sensors. We demonstrate the applicability of our transitive error modeling technique and evaluate its performance in various scenarios by conducting experiments using traces of the light intensity measurements recorded by in-field deployed light sensors. In addition, statistical validation and evaluation methods such as resubstitution are used in order to establish the interval of confidence
High Content Image-Based Screening of a Protease Inhibitor Library Reveals Compounds Broadly Active against Rift Valley Fever Virus and Other Highly Pathogenic RNA Viruses (2014)

High content image-based screening was developed as an approach to test a protease inhibitor small molecule library for antiviral activity against Rift Valley fever virus (RVFV) and to determine their mechanism of action. RVFV is the causative agent of severe disease of humans and animals throughout Africa and the Arabian Peninsula. Of the 849 compounds screened, 34 compounds exhibited ≥ 50% inhibition against RVFV. All of the hit compounds could be classified into 4 distinct groups based on their unique chemical backbone. Some of the compounds also showed broad antiviral activity against several highly pathogenic RNA viruses including Ebola, Marburg, Venezuela equine encephalitis, and Lassa viruses. Four hit compounds (C795-0925, D011-2120, F694-1532 and G202-0362), which were most active against RVFV and showed broad-spectrum antiviral activity, were selected for further evaluation for their cytotoxicity, dose response profile, and mode of action using classical virological methods and high-content imaging analysis. Time-of-addition assays in RVFV infections suggested that D011-2120 and G202-0362 targeted virus egress, while C795-0925 and F694-1532 inhibited virus replication. We showed that D011-2120 exhibited its antiviral effects by blocking microtubule polymerization, thereby disrupting the Golgi complex and inhibiting viral trafficking to the plasma membrane during virus egress. While G202-0362 also affected virus egress, it appears to do so by a different mechanism, namely by blocking virus budding from the trans Golgi. F694-1532 inhibited viral replication, but also appeared to inhibit overall cellular gene expression. However, G202-0362 and C795-0925 did not alter any of the morphological features that we examined and thus may prove to be good candidates for antiviral drug development. Overall this work demonstrates that high-content image analysis can be used to screen chemical libraries for new antivirals and to determine their mechanism of action and any possible deleterious effects on host cellular biology.
Fiber-coupled THz TDS system with mW-level THz power (2022)

We present a fully fiber-coupled THz TDS system with a record emitted THz power of 0.97 mW at 55 mW optical excitation power at the photoconductive emitter. The TDS system utilizes an erbium-doped fiber laser with separate amplifiers for both output arms in combination with rhodium-doped InGaAs-based THz antennas as emitter and receiver. For 1000 averages, a bandwidth of 6.5 THz and a peak dynamic range of 101 dB is achieved.
Chalcogenide Based Active and Passive Devices for Mid-IR Applications (2018)

We report on progress in development of chalcogenide based fiber and waveguide active and passive devices for routing, switching, and modulation of mid-IR sources for mid-IR applications. Optical performance of the devices will be reported.
Model Predictive Control for Real-time Position Tracking of a Catenary-free Tram (2017)

Automatic Train (or Tram) Operation (ATO) systems have been widely studied in the last decade to guarantee energy-efficient operation. Speed profiles and timetables are derived by applying optimization methods geared towards finding the optimal trade-off between journey time, emissions and energy efficiency. An on-board controller is required to track such optimal trajectories, despite model uncertainties. Due to the non-linear dynamics and non-holonomic constraints on both inputs and outputs, the tracking of such trajectories represents a difficult task. This paper deals with the design of the tracking algorithm, for a catenary-free tram, with regenerative braking. A Model Predictive Control (MPC) approach is used to track the optimal position profile. Thanks to the ability to easily deal with multivariable systems, make use of the references and disturbances preview, and enforce time-varying input/output constraints, MPC is the perfect candidate to fulfill this task. The proposed MPC formulation is simple enough to be implemented in real-time, with a quadratic programming solver. Results show that the algorithm tracks the position reference, and guarantees punctuality and comfort, while enforcing time-varying constraints on vehicle velocity, electrical machine and friction forces. The results are also confirmed in the case of operation with model mismatch.
In vivo microstructural investigation of the human tympanic membrane by endoscopic polarization-sensitive optical coherence tomography (2023)

The use of endoscopic PS-OCT is feasible to differentiate birefringent and nonbirefringent tissue of the human TM <i>in vivo</i>. Further investigations on healthy as well as pathologically altered TMs are required to validate the diagnostic potential of this technique.
Tailoring the energy distribution and loss of 2D plasmons (2016)

The ability to tailor the energy distribution of plasmons at the nanoscale has many applications in nanophotonics, such as designing plasmon lasers, spasers, and quantum emitters. To this end, we analytically study the energy distribution and the proper field quantization of 2D plasmons with specific examples for graphene plasmons. We find that the portion of the plasmon energy contained inside graphene (energy confinement factor) can exceed 50%, despite graphene being infinitely thin. In fact, this very high energy confinement can make it challenging to tailor the energy distribution of graphene plasmons just by modifying the surrounding dielectric environment or the geometry, such as changing the separation distance between two coupled graphene layers. However, by adopting concepts of parity-time symmetry breaking, we show that tuning the loss in one of the two coupled graphene layers can simultaneously tailor the energy confinement factor and propagation characteristics, causing the phenomenon of loss-induced plasmonic transparency.
Influence of interfacial strength on Micro- and macrosopie fatigue behavior of longitudinal glass fiberreinforced polypropylene (1997)

Influence of interfacial strength on Micro- and macrosopie fatigue behavior of longitudinal glass fiberreinforced polypropylene
Self-Improving System Integration - Status and Challenges after Five Years of SISSY (2018)

The self-improving system integration (SISSY) initiative has emerged in recent years in response to a systems engineering trend towards the organisation of open, interconnected systems integrating a large set of heterogeneous and autonomous subsystems. Based on the idea to equip subsystems with capabilities to assess and maintain their own integration status within the overall system composition, a variety of concepts, techniques, and contributions have been proposed and fruitfully discussed at the particular events of the underlying workshop series. In this article, we summarise and categorise these research efforts and derive a roadmap towards full-scale SISSY systems.
Status and Potential of Lithium Niobate on Insulator (LNOI) for Photonic Integrated Circuits (2018)

Abstract Lithium niobate on insulator (LNOI) technology is revolutionizing the lithium niobate industry, enabling higher performance, lower cost and entirely new devices and applications. The availability of LNOI wafers has sparked significant interest in the platform for integrated optical applications, as LNOI offers the attractive material properties of lithium niobate, while also offering the stronger optical confinement and a high optical element integration density that has driven the success of more mature silicon and silicon nitride (SiN) photonics platforms. Due to some similarities between LNOI and SiN, established techniques and standards can readily be adapted to the LNOI platform including a significant array of interface approaches, device designs and also heterogeneous integration techniques for laser sources and photodetectors. In this contribution, we review the latest developments in this platform, examine where further development is necessary to achieve more functionalities in LNOI integrated optical circuits and make a few suggestions of interesting applications that could be realized in this platform.
Accumulative Iterative Codes Based on Feedback (2021)

The Accumulative Iterative Code (AIC) proposed in this work is a new error correcting code for channels with feedback. AIC sends the information message to the receiver in a number of transmissions, where the initial transmission contains the uncoded message and each subsequent transmission informs the receiver about the locations of the errors that corrupted the previous transmission. Error locations are determined based on the forward channel output, which is made available to the transmitter through the feedback channel. AIC achieves arbitrarily low error rates, thereby being suitablefor applications demanding extremely high reliability. In the same time, AIC achieves spectral efficiencies very close to the channel capacity in a wide range of signal-to-noise ratios even for transmission of short information messages.
Implementation and early adaptation of patient-reported outcome measures into an electronic health record: A technical report (2018)

We integrated and optimized patient-reported outcome measures into the electronic health record to provide quantitative, objective data regarding patients' health status, which is important for patient care, payer contracts, and research. With a multidisciplinary team from information technology, clinical informatics, population health, and physician champions, we used formal human-computer interaction techniques and user-centered design to integrate several technology platforms and computerized adaptive testing for the National Institutes of Health Patient-Reported Outcomes Measurement Information System. The patient-reported outcome measure system leverages software frequently used by health systems and provides data for research and clinical care via a mobile-responsive web application using Symfony, with REDCap for configuring assessments and de-identified data storage. The system incorporates Oracle databases and Epic flowsheets. Patients complete patient-reported outcome measures, with data viewable in MyChart and Epic Synopsis Reports. Researchers can access data portals. The highly usable, successful patient-reported outcome measures platform is acceptable to patients and clinicians and achieved 73 percent overall completion rates.
Antigenic Targeting of the Human Mannose Receptor Induces Tumor Immunity (2007)

Pattern recognition receptors are preferentially expressed on APCs allowing selective uptake of pathogens for the initiation of antimicrobial immunity. In particular, C-type lectin receptors, including the mannose receptor (MR), facilitate APC-mediated adsorptive endocytosis of microbial glyconjugates. We have investigated the potential of antigenic targeting to the MR as a means to induce Ag-specific humoral and cellular immunity. hMR transgenic (hMR Tg) mice were generated to allow specific targeting with the anti-hMR Ab, B11. We show that hMR targeting induced both humoral and cellular antigenic specific immunity. Immunization of hMR Tg mice with B11 mAbs induced potent humoral responses independent of adjuvant. Injection of hMR Tg mice with mouse anti-hMR Ab clone 19.2 elicited anti-Id-specific humoral immunity while non-Tg mice were unresponsive. B11-OVA fusion proteins (B11-OVA) were efficiently presented to OVA-specific CD4 and CD8 T cells in MR Tg, but not in non-Tg, mice. Effector differentiation of responding T cells in MR Tg mice was significantly enhanced with concomitant immunization with the TLR agonist, CpG. Administration of both CpG and B11-OVA to hMR Tg mice induced OVA-specific tumor immunity while WT mice remained unprotected. These studies support the clinical development of immunotherapeutic approaches in cancer using pattern recognition receptor targeting systems for the selective delivery of tumor Ags to APCs.
Reversible work by electrochemical intercalation of graphitic materials (2005)

Graphite intercalation compounds are a class of materials systems formed as ions diffuse into a host graphite structure. The volume expansion associated with this process has been shown to be capable of performing work up to 3.8 MJ/m<sup>3</sup>. To evaluate GICs for solid state actuation, this study explores some factors affecting the rate at which the volume expansion occurs. Given that diffusion length has an exponential effect on rate, we tested a graphite paper comprised of 7-micron diameter PAN fibers. We found that the paper had ultimate strain and loading properties comparable to HOPG. The paper was cycled under various loads and temperatures to examine the strain rate and repeatability of the material. Testing showed a strong correlation between rate and temperature, while pressure had relatively little effect.
Lithographically Patterned Thin Activated Carbon Films as a New Technology Platform for On-Chip Devices (2013)

Continuous, smooth, visibly defect-free, lithographically patterned activated carbon films (ACFs) are prepared on the surface of silicon wafers. Depending on the synthesis conditions, porous ACFs can either remain attached to the initial substrate or be separated and transferred to another dense or porous substrate of interest. Tuning the activation conditions allows one to change the surface area and porosity of the produced carbon films. Here we utilize the developed thin ACF technology to produce prototypes of functional electrical double-layer capacitor devices. The synthesized thin carbon film electrodes demonstrated very high capacitance in excess of 510 F g(-1) (>390 F cm(-3)) at a slow cyclic voltammetry scan rate of 1 mV s(-1) and in excess of 325 F g(-1) (>250 F cm(-3)) in charge-discharge tests at an ultrahigh current density of 45,000 mA g(-1). Good stability was demonstrated after 10,000 galvanostatic charge-discharge cycles. The high values of the specific and volumetric capacitances of the selected ACF electrodes as well as the capacity retention at high current densities demonstrated great potential of the proposed technology for the fabrication of various on-chip devices, such as micro-electrochemical capacitors.
Pedobarographic and Musculoskeletal Examination of Collegiate Dancers in Relevé (2002)

Twenty-one collegiate ballet pupils were evaluated via history/questionnaire, musculoskeletal assessment, and pedobarographs, focusing on factors (e.g., alignment of hip, knee, and foot) thought to affect the important and common second-position relevé in dance. In a blinded manner, three observers classified the pedobarographs (obtained by an independent examiner) according to force distribution through the foot. Most dancers bore weight through the toes and transmitted force on both the medial and central metatarsal heads, and some transmitted force through only one of these rays, but none transmitted force through the lateral ray alone. This analysis provides a baseline for future assessment of normal or abnormal dance maneuvers.
Author Correction: Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology (2020)

A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20412-9.
Concentrated Bone Marrow Aspirate and Subacromial Bursa-Derived Cells Demonstrate Similar Cellular Adhesion and Proliferation Potential on Demineralized Bone Matrix Scaffolds for Biologic Augmentation of Rotator Cuff Repair (2020)

Background. Specific scaffolds are still required to sufficiently deliver and retain applied mesenchymal stem cells (MSCs) of various origins to the targeted zone of repaired tissue. The purpose of the study was to evaluate the demineralized bone matrix (DBM) as a scaffold for concentrated bone marrow aspirate (cBMA), subacromial bursa-derived cells (SBDCs), tenocytes, and osteoblasts. Methods. cBMA was harvested from the proximal humerus along with tenocytes and subacromial bursal tissue during arthroscopic shoulder surgery. Human osteoblasts were obtained from femoral condyles of patients undergoing total knee arthroplasty. Cells were seeded on a DBM scaffold. Cellular adhesion and proliferation assays were performed for each scaffold sample. Half of cBMA underwent arthroscopic simulation of being washed to mimic the intraoperative environment. Results. There was no significant difference in cellular adhesion potential on DBM scaffolds (p=0.168) when comparing SBDCs (meanSD: 25,77511,351), osteoblasts (meanSD: 33,1132,709), tenocytes (meanSD: 25,0003,864) and cBMA (meanSD: 25,0256,206). Osteoblasts (meanSD: 0.2790.009) showed a significantly higher proliferation potential (p=0.021, respectively) compared to SBDCs (meanSD: 0.2480.015), tenocytes (meanSD: 0.2390.011), and cBMA (meanSD: 0.2470.007). Histology sections and electron microscopy confirmed the presence of cells within the matrix of scaffolds. Conclusions. SBDCs and cBMA demonstrated high cellular adhesion and proliferation potential on DBM scaffolds.
Inhibition of CCL3 abrogated precursor cell fusion and bone erosions in human osteoclast cultures and murine collagen-induced arthritis (2018)

Inhibition of osteoclast-associated CCL3 reduced osteoclast formation and function whilst attenuating arthritis-associated bone loss and controlling development of erosion in murine joints, thus uncoupling bone damage from inflammation. Our findings may help future innovations for the diagnosis and treatment of inflammatory arthritis.
Semi-infinite quadratic optimization method using dual parametrization with application to antenna array (2006)

In this article, we consider the practical application of the dual parametrization method for semi-infinite quadratic optimization problems. It is known that the efficiency of the dual parametrization algorithm depends on the method used in its final local search step. For some practical problems, the variables representing the index points in the parametrized dual problem may be sensitive and available local search methods may have difficulty finding the precise optimal locations of the index positions. Thus, we propose modifications to the dual parametrization algorithm developed earlier to overcome these problems. The modified algorithm is applied to a general design of antenna arrays. Numerical results are compared with other design methods.
An exceptionally high boron content supramolecular cuboctahedron (2013)

A boron-rich supramolecular cuboctahedron containing an impressive 240 boron atoms has been synthesized via coordination-driven assembly. The cuboctahedron, which is composed of Cu(2+) paddle-wheel nodes and carborane-isophthalic acids, was obtained simply and in high purity. The ability to precisely characterize the nanostructure via X-ray diffraction makes it unique among boron-rich nanostructures.
Transient Nonlinear Phase-Shift in Epsilon-Near-Zero Materials (2020)

We present direct measurements of the nonlinearly induced phase-shift and spectral shift via beam-deflection technique and cross-phase modulation measurements. The optical nonlinearities are enhanced due to the highly dispersive nature of epsilon-near-zero materials, which allows obtaining reduced group velocity and enhanced phase velocity.