gebhart/patrepeval huggingface dataset:
Fluorescence imaging of reactive oxygen metabolites generated in single macrophage cells (NR8383) upon phagocytosis of natural zeolite (erionite) fibers. (1997)

In this paper we address the phenomenon of reactive oxygen metabolite generation subsequent to phagocytosis of mineral fibers by macrophages. Natural erionite fibers were chosen because of their established toxicity. Macrophages (cell line NR8383) were loaded with the dye 5-(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate and exposed to erionite particles by centrifuging cells and fibers together to effect adherence. Reactive oxygen metabolite generation was examined by monitoring the fluorescence of oxidized dye formed via the reaction with oxygen species produced during phagocytosis. Individual cells were repeatedly scanned for up to 2 hr to monitor the evolution of this fluorescence. It was found that erionite-exposed cells had a mean total fluorescence of three times that of controls during the first 35 min, declining to two times that of controls at 35-60 min and about the same level as that of controls at 60-80 min. Ultrastructural studies of similarly treated aliquots of cells showed marked variation in size and numbers of the phagocytized particles. This study demonstrates that intracellular oxidation can be monitored on a single cell basis over a period of time. Quantitative studies are in progress to establish the relationship between the phagocytized particulate load and the extent of fluorescence.
Catalytic Asymmetric Vinylation of Ketone Enolates (2001)

[see reaction]. A protocol for the catalytic asymmetric vinylation of ketone enolates has been developed. Key to the success of this process was the development of new electron-rich chiral monodentate ligands.
Perioperative Outcomes of Robotic and Open Partial Nephrectomy for Moderately and Highly Complex Renal Lesions (2012)

In our large institutional series of patients with moderate and highly complex solid renal tumors classified by the nephrometry score robotic partial nephrectomy offered comparable perioperative and functional outcomes with the added benefit of decreased hospital length of stay.
27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells (2017)

Purified microtubules have been shown to align along the static magnetic field (SMF) in vitro because of their diamagnetic anisotropy. However, whether mitotic spindle in cells can be aligned by magnetic field has not been experimentally proved. In particular, the biological effects of SMF of above 20 T (Tesla) have never been reported. Here we found that in both CNE-2Z and RPE1 human cells spindle orients in 27 T SMF. The direction of spindle alignment depended on the extent to which chromosomes were aligned to form a planar metaphase plate. Our results show that the magnetic torque acts on both microtubules and chromosomes, and the preferred direction of spindle alignment relative to the field depends more on chromosome alignment than microtubules. In addition, spindle morphology was also perturbed by 27 T SMF. This is the first reported study that investigated the cellular responses to ultra-high magnetic field of above 20 T. Our study not only found that ultra-high magnetic field can change the orientation and morphology of mitotic spindles, but also provided a tool to probe the role of spindle orientation and perturbation in developmental and cancer biology.
Rhodium‐Catalyzed Asymmetric Conjugate Additions of Boronic Acids to Enones Using DIPHONANE: A Novel Chiral Bisphosphine Ligand. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
ChemInform Abstract: SYNTHESIS AND HIGH‐PERFORMANCE LIQUID CHROMATOGRAPHY OF MALTULOSE AND CELLOBIULOSE (1983)

Abstract Maltose (I) wird unter den angegebenen Bedingungen zum Ketodisaccharid Maltulose (II) isomerisiert.
Unique Regulatory Mechanism for d -Galactose Utilization in Aspergillus nidulans (2011)

This study describes two novel regulators, GalX and GalR, that control d-galactose utilization in Aspergillus nidulans. This system is unique for A. nidulans since no GalR homologs were found in other ascomycetes. GalR shares significant sequence identity with the arabinanolytic and xylanolytic regulators AraR and XlnR, but GalX is more distantly related.
Gas Separation Using Membranes (1984)

Commercial membrane-based gas separator systems based upon high-flux, asymmetric polysulfone hollow fibers were first introduced in 1977 by Monsanto. These systems were packaged in compact modules containing large amounts of permeation surface area with productivities (flux/ft3 of module volume) of four to five orders of magnitude higher than previous pIate-and-frame modules. A number of other companies have also entered the field with high-flux dried cellulose acetate in hollow fiber and spiral-wound membrane' configurations. The fundamental principles governing membrane-based gas separations are reviewed in this paper, and examples of applications are presented
Optimizing Anti-Thymocyte Globulin Exposure to Improve Survival Chances after Hematopoietic Cell Transplantation for Acute Leukemia and Myelodysplastic Syndrome (2017)

Background: Anti-thymocyte globulin (ATG) is used to prevent graft-versus-host-disease (GvHD) following allogeneic hematopoietic cell transplantation (HCT). However, ATG can also cause delayed immune reconstitution, negatively influencing survival. We studied the relation between exposure to ATG and clinical outcomes in adult patients with acute leukemia and myelodysplastic syndrome. Methods: In a retrospective analysis, consecutive patients receiving a (9 or 10/10 allele) matched T-cell repleted allogeneic peripheral blood HCT with ATG (Thymoglobulin: 8 mg/kg in 4 from day -8) as part of reduced intensity conditioning (Fludarabine 90 mg/m2 and TBI 200cGy) were included (March-2004 to May-2015). Active-ATG levels were measured using a validated bioassay and pharmacokinetic (PK) exposure measures were calculated with a validated population PK-model. Main outcome of interest was overall survival (OS); other outcomes were relapse- and non-relapse mortality, acute- and chronic-GvHD and evaluation of current and optimal dosing. Cox proportional-hazard models and Fine-Gray competing risk models were used. Results: 146 patients (74 acute-myeloid leukemia, 36 acute-lymphoblastic leukemia and 36 myelodysplastic syndrome) with a median age of 50 (18.1-69.9) years were included. Median follow up was 37 (.6-139) months. Active-ATG exposure after HCT was found the only multivariate predictor for 5-year OS. Optimal exposure after HCT (60-95 AU*day/mL; 69 ± 8%) yielded superior OS compared to below (32 ± 8%, hazard ratio [HR] 3.36, 95% confidence interval [CI] 1.69-6.68, P = .00057) and above-optimal exposure (48 ± 6%, HR 2.5, 95%-CI 1.29-4.84, P = .0064: Figure 1). Above-optimal exposure led to higher relapse-related mortality (HR 2.66, P = .027), while below-optimal exposure increased non-relapse mortality (HR 4.17, P = .0060; Figure 1), grade 3-4 acute-GvHD (HR 3.09, P = .035) and chronic-GvHD (HR 2.56, P = .048). Dosing based on absolute lymphocyte counts led to higher optimal target attainment compared to weight-based dosing regimens (Figure 2).Figure 2View Large Image Figure ViewerDownload Hi-res image Download (PPT) Conclusions: ATG-exposure after HCT influences survival chances. These results stresses the importance of improving the efficacy and safety of ATG-dosing in HCT by amending dosing. Individualizing ATG-dosing, based on lymphocyte counts rather than body-weight, could result in improved survival chances after HCT.
Liquid-Crystal Level Equalizer Arrays on Fiber Arrays (2004)

We have developed simple and inexpensive level equalizer arrays using 8- to 16-channel independent liquid-crystal (LC) variable-optical-attenuator (VOA) arrays and multichannel in-line photodetector arrays, which were integrated on fiber arrays. We used two types of LC-VOAs: 1) ultrathin LC cells inserted into trenches cut across the fiber arrays, and 2) LC filling the gap between transparent electrode-coated fibers of the fiber splicer. The pitch of the fibers was 250 μm, and the number of fibers ranged from 8 to 16. These level equalizer arrays can suppress 2-Hz power fluctuations to a desired constant power level by using a dithering feedback circuit.
Polymerization Kinetics of Microgel Particles (2011)

This chapter contains sections titled: Introduction Polymerization Processes Kinetics of Polymerization Reaction Conclusions References
Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition (2023)

Correction to: Nature Genetics, published online 05 February 2020. In the published version of this paper, the members of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium were listed in the Supplementary Information; however, these members should have been included in the main paper. The original Article has been corrected to include the members and affiliations of the PCAWG Consortium in the main paper; the corrections have been made to the HTML version of the Article but not the PDF version. Additional corrections to affiliations have been made to the PDF and HTML versions of the original Article for consistency of information between the PCAWG list and the main paper. Additional affiliations have been added for author Kathleen H. Burns (McKusick-Nathans Institute of Genetic Medicine, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University School of Medicine, Baltimore, MD, USA) and author Guillaume Bourque (Canadian Center for Computational Genomics, McGill University, Montreal, Quebec, Canada).
Aluminium–salen luminophores as new hole-blocking materials for phosphorescent OLEDs (2008)

The organic light-emitting diodes (OLEDs) employing complex [salen(tBu)4Al(OC6H4-p-C6H5)] (4) as a hole-blocking layer produced stable green EL emission of Ir(ppy)3 irrespective of changing current density and showed higher brightness and device efficiency than the BAlq-based device.
Supplementary Table B from Coordinated Regulation of Cell Cycle Transcripts by p53-Inducible microRNAs, miR-192 and miR-215 (2023)

Supplementary Table B from Coordinated Regulation of Cell Cycle Transcripts by p53-Inducible microRNAs, miR-192 and miR-215
Optimum Power Allocation in a Hierarchical Spectrum Sharing Scheme (2008)

We consider a hierarchical spectrum sharing scheme wherein a secondary wireless system is allowed to share spectrum while maintaining priority for the primary system. Under this setting, we consider the problem of allocating transmit powers for the primary and secondary transmissions so as to maximize the sum rate of the two systems, while maintaining a minimum rate for the primary system. We determine the optimum power allocation for two cases corresponding to power values being (i) continuous real in a given range, and (ii) from a discrete set. We show that the optimal power allocation for both cases can be found to be one among a small set of points, and can be determined by an O(1) algorithm.
Database-Assisted Spectrum Prediction in 5G Networks and Beyond: A Review and Future Challenges (2019)

This article surveys the state of the art in spectrum prediction and learning, summarizes applications, techniques, main metrics, computational complexity, and provides practical examples. We focus on a cellular case study and define required improvements to database-assisted spectrum sharing. The use of history information and predictive spectrum modeling at different time scales provides valuable information to regulators, operators, and users of dynamic spectrum access networks. Prediction enables dynamic spectrum sharing systems to operate proactively, and consequently improves the performance in terms of reducing delays and interference among coexisting systems. Current database-assisted spectrum sharing concepts are in fact too static for many applications. Our numerical results on local-aware predictive spectrum allocation show the advantage of predictive operation in a vehicle-to-everything (V2X) scenario.
MPEG-21 digital item adaptation: enabling universal multimedia access (2004)

The access devices of today are becoming increasingly sophisticated. Thanks to multimedia, communication is much widespread and therefore more powerful. However, we face a serious problem of heterogeneity in our terminals, in our networks, and in the people who ultimately consume and interact with the information presented to them. In this article, we focus on Part 7 of the MPEG-21 standard (ISO/IEC 21000-7), which we refer to as Digital Item Adaptation (DIA). At the time of this writing, the DIA specification is at the penultimate stage of Final Committee Draft (2003); final approval is scheduled for December 2003. The general DIA concept is that Digital Item is subject to both a resource adaptation and a descriptor adaptation engine, which together produce the adapted Digital Item. Note that the standard specifies only the tools that assist with the adaptation process, not the adaptation engines themselves. Digital Item Adaptation (DIA) specifies the following natural environment description tools: location and time and audiovisual environment. The DIA offers a rich set of tools to assist with the adaptation of Digital Items. It offers standardized tools for the description of usage environments, tools to create high-level descriptions of the bitstream syntax to achieve format-independent adaptation, tools that assist in making tradeoffs between feasible adaptation operations and constraints, tools that enable low-complexity adaptation of metadata, and tools for session mobility. Moving forward, the MPEG-21 committee is considering amendments to the specification-for instance, tools that provide further assistance with modality conversion and tools that relate more specifically to the adaptation of audio and graphics media. Furthermore, also being actively considered is how to express the rights that a User has to perform adaptation and how this expression fits into a system that governs those rights.
Device Characteristics of Trigate-FET with Barrier Constrictions in the Channel (2009)

We have investigated the effect of symmetric geometrical constrictions on the device characteristics of ultrathin silicon-on-insulator (SOI) nanowire with Trigate structure by means of the full real-space three dimensional Nonequilibrium Greens's Function (NEGF) method. In this study, geometrical constrictions are introduced as energy barriers near the source and the drain junctions and their strength is modulated by the potential height and the geometry. Interestingly, even at room temperature the drain current in the device shows oscillations as a function of the applied gate voltage. This can be traced to the development of transmission resonances as the channel is additionally confined along the current direction.
Anticancer Activities of Brassinosteroids (2012)

Molecular and cellular effects of two groups of antiproliferative agents, natural brassinosteroids (BRs) and their synthetic derivatives, were examined in different human cancer cell lines and in primary endothelial cells in vitro. Natural and synthetic BRs caused growth inhibition, cell cycle arrest and initiation of apoptosis in many different cancer cell lines. The inhibition of proliferation and migration of human endothelial cells by BRs was demonstrated and evidences were obtained that BRs initiate cell death by apoptosis. And, analogues of BRs were found to be more effective than natural BRs. Observed inhibition of migration and tube formation demonstrated the antiangiogenic activity of BRs. These findings indicate a potential use of BRs in the prevention of metastasis development. Investigation of the mechanisms of action of BRs in human cancer and endothelial cells using cellular and molecular techniques indicated the possible involvement of steroid receptors in BR action. However, BRs were shown not to bind directly to steroid receptors which demonstrate that BRs act via steroid receptor-independent pathway(s). Concluding, BRs and their derivatives are capable to inhibit growth of several human cancer cell lines and to inhibit angiogenesis-like behaviour of primary endothelial cells in vitro, as well.
Blind fractionally spaced equalization of noisy FIR channels: direct and adaptive solutions (1997)

Blind fractionally spaced equalizers reduce intersymbol interference using second-order statistics without the need for training sequences. Methods for finding FIR zero-forcing blind equalizers directly from the observations are described, and adaptive versions are developed. In contrast, most current methods require channel estimation as a first step to estimating the equalizer. The direct methods can be zero-forcing, minimum mean-square error, or even minimum mean square error (MMSE) within the class of zero-forcing equalizers. Performance of the proposed methods and comparisons with existing approaches are shown for a variety of channels, including an empirically measured digital microwave channel.
Assessment of Bis-macrocyclic Compounds as Calcium-sensitive MR Contrast Agents (2005)

Introduction. The ability of non-invasively observing changes in the Ca2+ concentrations is important in the understanding of a great variety of neuronal processes. Several compounds were designed (Fig.1) to take advantage of the different binding abilities of carboxylates and phosphonates to gadolinium. Furthermore the different affinities of the two functional groups to Ca2+ permit to obtain free coordination sites at gadolinium. The generation of these coordination sites, which are mandatory for water relaxivity, depends on the structure of the complexes and the Ca2+ concentration. Gadolinium complexes 1 and 2 were synthesized and relaxivity studies were performed. Methods. For measurements of the relaxivities r1 and r2, concentrations of 0.1, 0.4, 0.7, and 1 mM of the CA and different concentrations of Ca2+ (0, 1.0, 10.0 and 100.0 mM) were used at pH 7.2 in a KMOPS buffer. Relaxivity r1,2 was calculated from the slope of R1,2(c) versus the CA concentration by an error-weighted linear regression. Results. Changes of relaxivity was observed for the different Ca2+ concentrations (Fig. 2). An increase of the Ca2+ concentration between 10 to 100 mM enlarged relaxivity up to 20. According to the results shown it is expected that by the incorporation of more structural constraints into the acyclic part (X and Y) changes in relaxivity can be moved towards the range of physiological conditions (i.e. 1mM in the extracellular space).
Structure–activity relationships of radioiodinated diphenyl derivatives with different conjugated double bonds as ligands for α-synuclein aggregates (2016)

We investigated the structure–activity relationships of radioiodinated diphenyl (IDP) derivatives with different conjugated double bonds as ligands for α-syn aggregates.
Interference coordination and cancellation for 4G networks (2009)

This article provides an overview of contemporary and forward looking inter-cell interference coordination techniques for 4G OFDM systems with a specific emphasis on implementations for LTE. Viable approaches include the use of power control, opportunistic spectrum access, intra and inter-base station interference cancellation, adaptive fractional frequency reuse, spatial antenna techniques such as MIMO and SDMA, and adaptive beamforming, as well as recent innovations in decoding algorithms. The applicability, complexity, and performance gains possible with each of these techniques based on simulations and empirical measurements will be highlighted for specific cellular topologies relevant to LTE macro, pico, and femto deployments for both standalone and overlay networks.
Faster qualification of 193-nm resists for 100-nm development using photo cell monitoring (2003)

The development of 100-nm design rule technologies is currently taking place in many R&amp;D facilities across the world. For some critical alyers, the transition to 193-nm resist technology has been required to meet this leading edge design rule. As with previous technology node transitions, the materials and processes available are undergoing changes and improvements as vendors encounter and solve problems. The initial implementation of the 193-nm resits process did not meet the photolithography requirements of some IC manufacturers due to very high Post Exposure Bake temperature sensitivity and consequently high wafer to wafer CD variation. The photoresist vendors have been working to improve the performance of the 193-nm resists to meet their customer's requirements. Characterization of these new resists needs to be carried out prior to implementation in the R&amp;D line. Initial results on the second-generation resists evaluated at Cypress Semicondcutor showed better CD control compared to the aelrier resist with comparable Depth of Focus (DOF), Exposure Latitute, Etch Resistance, etc. In addition to the standard lithography parameters, resist characterization needs to include defect density studies. It was found that the new resists process with the best CD control, resulted in the introduction of orders of magnitude higher yield limiting defects at Gate, Contact adn Local Interconnect. The defect data were shared with the resists vendor and within days of the discovery the resist vendor was able to pinpoint the source of the problem. The fix was confirmed and the new resists were successfully released to production. By including defect monitoring into the resist qualification process, Cypress Semiconductor was able to 1) drive correction actions earlier resulting in faster ramp and 2) eliminate potential yield loss. We will discuss in this paper how to apply the Micro Photo Cell Monitoring methodology for defect monitoring in the photolithogprhay module and the qualification of 193nm resist processes.
Search for invisible decays of a Higgs boson produced through vector boson fusion in proton-proton collisions at s=13TeV (2019)

A search for invisible decays of a Higgs boson is performed using proton-proton collision data collected with the CMS detector at the LHC in 2016 at a center-of-mass energy s = 13 TeV, corresponding to an integrated luminosity of 35.9 fb -1 . The search targets the production of a Higgs boson via vector boson fusion. The data are found to be in agreement with the background contributions from standard model processes. An observed (expected) upper limit of 0.33 (0.25), at 95% confidence level, is placed on the branching fraction of the Higgs boson decay to invisible particles, assuming standard model production rates and a Higgs boson mass of 125.09 GeV. Results from a combination of this analysis and other direct searches for invisible decays of the Higgs boson, performed using data collected at
An experimental study of ranging techniques in a tunnel environment (2013)

This paper presents a preliminary experimental analysis of the ranging techniques using UWB measurements obtained in a tunnel at Linkoping university. According to our results, range estimates based on time-of-arrival are very accurate in LOS and all NLOS scenarios with thin obstacles. However, there is a relatively large bias when a NLOS is caused by a tunnel wall.