gebhart/patrepeval huggingface dataset:
Functional and ultrastructural studies of Sezary cells. (1976)

A patient having clinical findings and typical ultrastructure of the peripheral white blood cells compatible with the diagnosis of Sézary syndrome is described. Studies of the synthesizing capacity of the Sézary cells showed a statistically significant increase in their capacity for protein and RNA synthesis, but no difference with regard to DNA synthesis as compared to normal lymphocytes.
Modélisation analytique de l'inducteur d'un accouplement magnétique supraconducteur à flux axial (2013)

National audience
Tuning Singlet and Triplet Excited State Energies and Frontier Orbitals of Imidazole Host/Emitter for Hybrid White OLEDs (2019)

In this work, we report hybrid fluorescent/phosphorescent WOLEDs employing blue fluorescent and green and red phosphorescent emitters doped into a host matrix. The fluorescent emitting dopant harnesses all electrically generated high energy singlet excitons for blue emission, and the phosphorescent dopants harvest the remainder of lower-energy triplet excitons for green and red emission. This design requires the singlet state (S1) of the host to be higher than the S1 of the fluorescent dopant so that the singlet excitons generated on the host are transferred to the fluorescent dopant. Furthermore, the triplet state (T1) of the host matrix should be lower than the T1 of the fluorescent dopant so the triplet excitons generated on the fluorescent dopant can be transferred to the host matrix which will then be transferred to the green and red phosphors. To develop a host material that can serve this purpose, we tune the electronic properties of phenanthro[9,10-d]imidazole by incorporating phenyl and/or pyridyl moieties at the N1 and C2 positions of phenanthro[9,10-d]imidazole. This substitution resulted in variety of host materials with different singlet/triplet energies, quantum efficiency and redox values. The resulting phenanthro[9,10-d]imidazoles are employed as host materials for fluorescent and phosphorescent dopants and as neat fluorescent emitters. Monochromatic devices with a fluorescent emitter and the phenanthro[9,10-d]imidazoles as host materials or as neat fluorescent emitter achieved near theoretical maximum efficiency. Finally, efficient three-color hybrid WOLEDs were fabricated using the phenanthro[9,10-d]imidazoles as hosts for a fluorescent dopant or as neat fluorescent emitters and host for green and red phosphors.
AC interconnection between longitudinal power systems - The Chilean case (2015)

This paper presents a comprehensive study about low frequency oscillations and transient stability when considering the interconnection of an extreme longitudinal power system with a second system through a tie line. The evolution of critical low frequency oscillation modes is investigated as the power transfer through the tie line increases. Time domain simulations are also conducted in order to verify some of the obtained results in the linear analysis. The simulations are based on detailed models of the two main power systems in Chile. The tie line model is based on technical data of the AC interconnection project which is under construction in Chile today.
Computers' impact on productivity and work life (1988)

Rapid spread of computer and telecommunication technologies throughout white-collar work has forced researchers to consider their impacts on the people who use them. The present study uses a multi-method, lagged, time-series design to examine the impact of a computerized record system on the work life of customer service representatives in a large utility company. Results show that the computer technology had mixed effects in terms of both productivity and quality of working life, and that these effects varied depending on local organizational culture, management quality, type of worker and their detailed work tasks. Furthermore, during the year in which the computer system was being introduced, the computer system itself, its methods of use, and the managerial goals that spawned it all evolved in response to workers and other factors. These results are used to illustrate the conceptual and methodological complexities involved in establishing the causal impact of computer technology, and to suggest alternate methods for thinking about and measuring technological impact.
Self-organization in cellular neural networks: a comparison with Kohonen's self-organizing maps (2002)

The ordinary differential equation (ODE) method is difficult to use for analyzing the self-organization of the Kohonen algorithm. Two stochastic, 'self-organizing' algorithms, whose corresponding ODE is a CNN equation, are presented. Their convergence shares similar features with the Kohonen self-organizing process.
Fast adaptation of pre-operative patient specific models to real-time intra-operative volumetric data streams. (2011)

Image-guided catheter ablation therapy is becoming an increasingly popular treatment option for atrial fibrillation. Successful treatment relies on accurate guidance of the treatment catheter. Integration of high-resolution, pre-operative data with electrophysiology data and positional data from tracked catheters improves targeting, but lacks the means to monitor changes in the atrial wall. Intra-operative ultrasound provides a method for imaging the atrial wall, but the real-time, dynamic nature of the data makes it difficult to seamlessly integrate with the static pre-operative patient-specific model. In this work, we propose a technique which uses a self-organizing map (SOM) for dynamically adapting a pre-operative model to surface patch data. The surface patch would be derived from a segmentation of the anatomy in a real-time, intra-operative ultrasound data stream. The method is demonstrated on two regular geometric shapes as well as data simulated from a real, patient computed tomography dataset.
The Phenolics and Antioxidant Properties of Black and Purple versus White Eggplant Cultivars (2022)

The total phenolic content, anthocyanins, phenolic acids, antioxidant capacity and α-amylase inhibitory activity of black (Aydin Siyahi), purple (Kadife Kemer) and white (Trabzon Kadife) eggplants grown in Turkey were subjected to a comparative investigation. The black cultivar exhibited the highest total phenolic (17,193 and 6552 mg gallic acid equivalent/kg fw), flavonoid (3019 and 1160 quercetin equivalent/kg fw) and anthocyanin (1686 and 6167 g delphinidin-3-<i>O</i>-glucoside equivalent/kg fw) contents in crude extracts of the peel and pulp. The majority of the caffeic acid was identified in the ester (2830 mg/kg fw) and ester-bound (2594 mg/kg fw) forms in the peel of 'Kadife Kemer' and in the glycoside form (611.9 mg/kg fw) in 'Aydin Siyahi', as well as in the pulp of these two eggplants. 'Kadife Kemer' (purple eggplant) contained the majority of the chlorogenic acid in free form (27.55 mg/kg fw), compared to 'Aydin Siyahi' in the ester (7.82 mg/kg fw), glycoside (294.1 mg/kg dw) and ester-bound (2.41 mg/kg fw) forms. The eggplant cultivars (peel and pulp, mg/kg fw) exhibited a relatively high delphinidin-3-<i>O</i>-rutinoside concentration in the peel of 'Aydin Siyahi' (avg. 1162), followed by 'Kadife Kemer' (avg. 336.6), and 'Trabzon Kadife' (avg. 215.1). The crude phenolic extracts of the eggplants exhibited the highest antioxidant capacity values (peel and pulp, µmoL Trolox equivalent/kg fw) of 2,2-diphenyl-1-picrylhydrazyl (DPPH, 8156 and 2335) and oxygen radical absorbance capacity (ORAC, 37,887 and 17,648). The overall results indicate that black and purple eggplants are the cultivars with greater potential benefits in terms of their phenolics and antioxidant values than the white eggplant.
Three‐Component Enantioselective Synthesis of Propargylamines through Zr‐Catalyzed Additions of Alkyl Zinc Reagents to Alkynylimines (2003)

Readily available amino acid based chiral ligands are used in a three-component Zr-catalyzed enantioselective synthesis of propargylamines (see schemes). The reaction affords important enantiomerically enriched building blocks that are not conveniently accessible by alternative catalytic methods.
Data from Optimizing precision medicine for breast cancer brain metastases with functional drug response assessment. (2023)

&lt;div&gt;Abstract&lt;p&gt;The development of novel therapies for brain metastases is an unmet need. Brain metastases may have unique molecular features that could be explored as therapeutic targets. A better understanding of the drug sensitivity of live cells coupled to molecular analyses will lead to a rational prioritization of therapeutic candidates. We evaluated the molecular profiles of twelve breast cancer brain metastases (BCBM) and matched primary breast tumors to identify potential therapeutic targets. We established six novel patient-derived xenograft (PDX) from BCBM from patients undergoing clinically indicated surgical resection of BCBM and used the PDXs as a drug screening platform to interrogate potential molecular targets. Many of the alterations were conserved in brain metastases compared to the matched primary. We observed differential expressions in the immune-related and metabolism pathways. The PDXs from BCBM captured the potentially targetable molecular alterations in the source brain metastases tumor. The alterations in the PI3K pathway were the most predictive for drug efficacy in the PDXs. The PDXs were also treated with a panel of over 350 drugs and demonstrated high sensitivity to HDAC and proteasome inhibitors. Our study revealed significant differences between the paired BCBM and primary breast tumors with the pathways involved in metabolisms and immune functions. While molecular-targeted drug therapy based on genomic profiling of tumors is currently evaluated in clinical trials for patients with brain metastases, a functional precision medicine strategy may complement such an approach by expanding potential therapeutic options, even for BCBM without known targetable molecular alterations.&lt;/p&gt;&lt;/div&gt;
Integration of a dilution range using collapsible chambers in a X-Y architecture (2017)

International audience
Gaussian process regression: active data selection and test point rejection (2000)

We consider active data selection and test point rejection strategies for Gaussian process regression based on the variance of the posterior over target values. Gaussian process regression is viewed as transductive regression that provides target distributions for given points rather than selecting an explicit regression function. Since not only the posterior mean but also the posterior variance are easily calculated we use this additional information to two ends: active data selection is performed by either querying at points of high estimated posterior variance or at points that minimize the estimated posterior variance averaged over the input distribution of interest or (in a transductive manner) averaged over the test set. Test point rejection is performed using the estimated posterior variance as a confidence measure. We find that, for both a two-dimensional toy problem and a real-world benchmark problem, the variance is a reasonable criterion for both active data selection and test point rejection.
Intramolecular [4 + 4] photocycloaddition of 2-pyridones tethered by a three-carbon chain: studies on the formation of cycloadducts and control of stereogenesis. 3 (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular [4 + 4] photocycloaddition of 2-pyridones tethered by a three-carbon chain: studies on the formation of cycloadducts and control of stereogenesis. 3Scott M. Sieburth, Gary Hiel, C.-H. Lin, and Dora P. KuanCite this: J. Org. Chem. 1994, 59, 1, 80–87Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/jo00080a015https://doi.org/10.1021/jo00080a015research-articleACS PublicationsRequest reuse permissionsArticle Views329Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
112 Reduction of vibration in tractor using semi-active suspension (2001)

Recently the development of agriculture vehicles such as a tractor has brought new demands on cabin environment. Especially the improvement of ride comfort has become increasingly important. As the measures of vibration reduction, only rubber bushes are just installed in conventional tractors. Therefore the vibration from road is directly transmitted to the driver in the cabin, consequently the driver is continuously persecuted by this vibration. This paper presents the method of the vibration reduction of the using semi-active suspension system for cabin mount and horizontal direction to provide the comfortable working environment for the driver.
Multicast based Middleware for Parallel Stream Processing (2007)

The paper presents the design and evaluation of ultimate stream: middleware that allows real-time delivery of streaming video data to all computers in a local multicast group. No special hardware or software support other than standard TCP/IP multicast over a local subnet is required. Frame level data shredding and reconstruction are used to provide consistency and synchronization without retransmission. A prototype scientific application (MouseCam) was implemented to evaluate our design in a practical context. The middleware layer is flexible enough to work with a number of different types of data, including sequential JPEG images, as used in this prototype. The MouseCam prototype demonstrates that our software can be effectively used as a backbone inside a private subnet to transfer large amounts of streaming data to multiple nodes in real-time for subsequent processing in parallel.
cDNA Cloning and Expression of a Human Platelet-Derived Growth Factor (PDGF) Receptor Specific for B-Chain-Containing PDGF Molecules (1988)

The structure of the human receptor for platelet-derived growth factor (PDGF) has been deduced through cDNA cloning. A 5.45-kilobase-pair cDNA clone predicts a 1,106-amino-acid polypeptide, including the cleavable signal sequence. The overall amino acid sequence similarity with the murine PDGF receptor is 85%. After transcription of the cDNA and translation in vitro, a PDGF receptor antiserum was used to immunoprecipitate a product of predicted size, which also could be phosphorylated in vitro. Stable introduction of the cDNA into Chinese hamster ovary (CHO) cells led to the expression of a 190-kilodalton component, which was immunoprecipitated by the PDGF receptor antiserum; this most probably represents the mature PDGF receptor. Binding assays with different 125I-labeled dimeric forms of PDGF A and B chains showed that the PDGF receptor expressed in CHO cells bound PDGF-BB and, to a lesser extent, PDGF-AB, but not PDGF-AA.
Measuring Quality of Care in Patients With Nonvariceal Upper Gastrointestinal Hemorrhage: Development of an Explicit Quality Indicator Set (2010)

We have developed an explicit set of evidence-based QIs in NVUGIH, providing physicians and institutions with a tool to identify processes amenable to quality improvement. This tool is intended to be applicable in all institutions providing care for NVUGIH patients.
Synthesis of an iron(IV) cyanide complex that contains the triamido amine ligand [(tert-BuMe2SiNCH2CH2)3N]3- (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of an iron(IV) cyanide complex that contains the triamido amine ligand [(tert-BuMe2SiNCH2CH2)3N]3-C. C. Cummins and R. R. SchrockCite this: Inorg. Chem. 1994, 33, 2, 395–396Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/ic00080a033https://doi.org/10.1021/ic00080a033research-articleACS PublicationsRequest reuse permissionsArticle Views648Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Inversion-based method for interpretation of logging-while-drilling density measurements acquired in high-angle and horizontal wells (2012)

ABSTRACT We introduce a sector-based inversion method to improve the petrophysical interpretation of logging-while-drilling density measurements acquired in high-angle and horizontal wells. The central objective is to reduce shoulder-bed effects on the measurements. This approach is possible because of a recently developed technique to accurately and efficiently simulate borehole density measurements. The inversion-based interpretation method consists of first detecting bed boundaries from short-spacing detector or bottom-quadrant compensated density by calculating their variance, representative of the measurement inflection point, within a sliding window. Subsequently, a correlation algorithm calculates dip and azimuth from the density image. Depth shifts that vary azimuthally and depend on relative dip angle, together with the effective penetration length of each sensor, refine previously selected bed boundaries. Next, the inversion method combines sector-based density measurements acquired at all measurement points along the well trajectory to estimate layer-by-layer densities. In the presence of standoff, the method excludes upper sectors most affected by standoff to reduce inaccuracies due to borehole mud. To verify the reliability and applicability of the inversion method, we first use forward simulations to generate synthetic density images for a model constructed from field data. Results indicate that inversion improves the interpretation of azimuthal density data as it consistently reduces shoulder-bed effects. Inversion results obtained from field measurements are appraised by quantifying the corresponding integrated porosity-meter yielded by inversion methods in comparison to standard techniques that use simple cutoffs on field-processed compensated density. Integrated porosity-meter of inverted synthetic density measurements increases by 4.6% with respect to noninverted field measurements. Also, integrated porosity-meter obtained from inversion results that include only bottom sectors improved by 65.4% with respect to that calculated with field-compensated, bottom-quadrant density measurements.
Incorporation of Basic Side Chains into Cryptolepine Scaffold: Structure−Antimalarial Activity Relationships and Mechanistic Studies (2011)

The synthesis of cryptolepine derivatives containing basic side-chains at the C-11 position and their evaluations for antiplasmodial and cytotoxicity properties are reported. Propyl, butyl, and cycloalkyl diamine side chains significantly increased activity against chloroquine-resistant Plasmodium falciparum strains while reducing cytotoxicity when compared with the parent compound. Localization studies inside parasite blood stages by fluorescence microscopy showed that these derivatives accumulate inside the nucleus, indicating that the incorporation of a basic side chain is not sufficient enough to promote selective accumulation in the acidic digestive vacuole of the parasite. Most of the compounds within this series showed the ability to bind to a double-stranded DNA duplex as well to monomeric hematin, suggesting that these are possible targets associated with the observed antimalarial activity. Overall, these novel cryptolepine analogues with substantially improved antiplasmodial activity and selectivity index provide a promising starting point for development of potent and highly selective agents against drug-resistant malaria parasites.
Assessments of skin and tongue microcirculation reveals major changes in porcine sepsis (2010)

Capillary bleedings may be used as an early indication of severe sepsis. Examination of skin and tongue microcirculations may be used to characterize severity of sepsis and possibly to assess effect of treatment.
Liquid-liquid equilibria for polymer solutions and blends, including copolymers (1995)

A simplified perturbed hard-sphere-chain (PHSC) theory is applied to interpret, correlate, and (in part) predict liquid-liquid equilibria (LLE) for polymer solutions and blends, including copolymers. The PHSC equation of state uses a hard-sphere-chain reference system plus a van der Waals attractive perturbation. Three pure-component parameters are obtained from readily available thermodynamic properties. Mixture parameters are obtained using pure-component parameters, conventional combining rules, and one or two binary constants. Theoretical and experimental coexistence curves and miscibility maps show good agreement for selected blends containing polymers and copolymers. For LLE of dilute or semi-dilute solvent/polymer solutions, it is necessary to decrease the pure-component polymer chain length, probably because the mean-field approximation is not suitable for such solutions.
Impact of Regiochemistry and Isoelectronic Bridgehead Substitution on the Molecular Shape and Bulk Organization of Narrow Bandgap Chromophores (2013)

A comparison of two classes of small molecules relevant to the field of organic electronics is carried out at the molecular and supramolecular levels. First, two molecules that differ only in the position of a pyridyl N-atom within an acceptor fragment are compared and contrasted. X-ray investigation of single crystals reveals that positioning the pyridyl N-atoms proximal to the molecules center changes the molecular shape by bending the molecule into a banana shape. Second, we demonstrate that the banana shape of the molecule can be controlled by replacing a Si atom within the dithienosilole fragment with a C or Ge atom. Here, utilization of cyclopentadithiophene or dithienogermole as the internal electron-rich unit leads to a decrease or an increase in the bending of the conjugated backbone, respectively. Such molecular shape changes alter intermolecular packing and thus affect bulk properties, leading to large differences in the optical, thermal, and crystallization properties.