gebhart/patrepeval huggingface dataset:
Factors related to early mortality in cirrhotic patients bleeding from varices and treated by urgent sclerotherapy. (1992)

Variceal haemorrhage in cirrhotic patients carries a high early mortality even when balloon tamponade or emergency sclerotherapy are applied. The aim of this study to identify patients dying within six weeks of their first variceal haemorrhage. One hundred and twenty one patients with parenchymal cirrhosis presenting with the first variceal bleeding episode between June 1983 and December 1988 were studied. Nineteen patients were excluded for various reasons. Emergency sclerotherapy was carried out in cases of active bleeding or where there were endoscopic signs of recent bleeding, and then regularly repeated afterwards. Of the 24 variables studied and included in a multivariate analysis using a logistic regression model, three had an independent prognostic value: encephalopathy, prothrombin time, and the number of blood units transfused within the 72 hours of time zero. The subsequent regression equation was able to predict 89% of the patients who will die and 97% of the patients who will still be alive six weeks after their first variceal haemorrhage treated by sclerotherapy. Pugh score was less discriminatory than these last three variables in terms of accuracy of adjustment, goodness of fit to the model, receiver operating characteristic curves, and percentage correct prediction. To measure the accuracy of the prediction rule, our model was applied to another series of 28 cirrhotic patients admitted with their first variceal bleeding during the next period (January 1989 to May 1990). Death and survival were correctly predicted in respectively 82% and 94% of the cases. The use of this score is recommended for the selection of patients with high early mortality after variceal bleeding despite sclerotherapy, and for the design of new therapeutic trials.
Correlation Between the Interval of Influenza Virus Infectivity and Results of Diagnostic Assays in a Ferret Model (2015)

Antigen-detection testing and virus culture but not real-time RT-PCR identified the end of the infectious period.
Effect of thermal annealing and surface coverage on porous silicon photoluminescence (1992)

The effect of thermal annealing and surface coverage on porous silicon photoluminescence was studied in situ in an ultrahigh vacuum chamber. These investigations correlated simultaneously temperature, surface coverage, and photoluminescence intensity. The surface coverage was monitored using transmission Fourier transform infrared spectroscopy. The results demonstrated that the photoluminescence could not be defined only according to the presence of SiH2 surface species. Likewise, the disappearance of the photoluminescence versus thermal annealing did not scale directly with H2 desorption from SiH2 species. The loss of photoluminescence versus thermal annealing was attributed to surface structural changes or the production of surface states which provide pathways for nonradiative recombination.
Hemodialysis Reliable Outflow (HeRO) graft creation in upper extremities abandoned due to stent obstruction via recanalization and HeRO outflow component insertion across stent interstices (2021)

HeRO graft insertion across stent interstices is feasible and can provide effective permanent AV access; thus, the presence of stents across the subclavian and brachiocephalic veins should not be considered a contraindication.
Effects of fenoldopam infusion in complex cardiac surgical operations: a prospective, randomized, double-blind, placebo-controlled study. (2010)

Fenoldopam improves the quality of perfusion during CPB. In patients receiving catecholamines to treat a postoperative low cardiac output state, fenoldopam significantly improves renal function and prevents AKI and major morbidity.
Dust Static Cylindrically Symmetric Solutions in f(R) Gravity (2014)

This paper is devoted to investigate non-vacuum solutions of cylindrically symmetric spacetime in the context of metric f(R) gravity. We take dust matter to find energy density of the universe. In particular, we find two exact solutions, which correspond to two f(R) models in each case. The first solution provides constant curvature while the second solution corresponds to non-constant curvature. The functions of the Ricci scalar and energy densities are evaluated in each case.
Multivariate Correlation Analysis Suggested High Ubiquinol and Low Ubiquinone in Plasma Promoted Primate ’ s Social Motivation and IR Detected Lower Body Temperature (2013)

Mental problems caused by various kinds of stress induce neurotoxic damage through biological mechanisms like oxidation or metabolic unbalancing. We evaluated the dietary supplementation of antioxidant and nutrition, ubiquinol with milk in normal isolated adult common marmoset (Callithrix jacchus) as a preliminary preclinical study. The primates were fed with milk with or without ubiquinol every day for three months and after a two-month-interval, the treatment conditions were alternated. Psycho-physiological state was evaluated by video-recording of social behavior, body temperature detection by a simple IR thermal camera and a blood glucose chip-sensor. Furthermore, social behavior data were information-processed by technology to integrate multiple factors, ‘Behavior output analysis for quantification of emotional state translation’ abbreviated as BOUQUET, which visualized a statistical partial space where the status of high ubiquinol and low ubiquinone in plasma strongly correlated with high frequency of social approaching behavior and lower body temperatures in a social meeting context. This analysis also suggested that high frequency of face direction to a peer correlated with the high ubiquinol-low ubiquinone and high variation of body temperature. Blood glucose seemed weakly relevant to alert behavior in this multiple correlation. These results imply that unbiquinol supplementation promotes social motivation. Finally, the result that the BOUQUET and the sensor systems revealed the implicit psycho-physiological information suggests its applicability in various toxico-psychopathological studies as quantitative manner.
The olefin metathesis-transannular ene sequence: a method for the stereocontrolled synthesis of trans-decalin derivatives. 2. Formal eudesmane syntheses (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleThe olefin metathesis-transannular ene sequence: a method for the stereocontrolled synthesis of trans-decalin derivatives. 2. Formal eudesmane synthesesPaul A. Wender and Leo J. LetendreCite this: J. Org. Chem. 1980, 45, 2, 367–368Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://doi.org/10.1021/jo01290a040RIGHTS & PERMISSIONSArticle Views247Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (244 KB) Get e-Alerts Get e-Alerts
Prevalence of methylenetetrahydrofolate reductase gene polymorphisms (C677T, and A1298C) among Saudi children receiving dental treatment (2021)

None.
Effects of immune architecture on response to adjuvant capecitabine in triple-negative breast cancer (FinXX trial). (2019)

3142 Background: Recent studies have demonstrated a benefit of adjuvant capecitabine, particularly in triple negative breast cancer (TNBC) patients with residual disease after neoadjuvant chemotherapy. However, biomarkers to predict which patients are more likely to benefit from capecitabine are needed. Methods: The nanoString Breast Cancer 360 (BC360) and PanCancer Immunoncology (IO360) panels were used to quantify mRNA expression in TNBC samples in the FinXX trial. FinXX is a phase III trial which randomized high risk patients to receive either 3 cycles of docetaxel followed by 3 cycles of cyclophosphamide, epirubicin, and fluorouracil (Arm A: T+CEF) vs. 3 cycles of docetaxel plus capecitabine followed by 3 cycles of cyclophosphamide, epirubicin, and capecitabine (Arm B: TX+CEX). Gene signature scores were analyzed using prespecified algorithms developed by nanoString. Digital Spatial Profiling was carried out using GeoMX platform. Results: A total of 111 TNBC patients in FinXX trial were included (57 in Arm A and 54 in Arm B) with 10.2 years median follow up. There were 7 cancer- and immune-related gene signatures identified by BC360 and IO360 panels that were significantly associated with improved recurrent free survival favoring an addition of capecitabine. These include cytotoxic cell signature (HR 0.37, 95%CI 0.15-0.92, p 0.03), endothelial signature (HR 0.18, 95%CI 0.04-0.83, p 0.03), mast cell signature (HR 0.43, 95%CI 0.21-0.88, p 0.02), PDL2 gene (HR 0.29, 95%CI 0.09-0.99, p 0.05), immunoproteasome (HR 0.34, 95%CI 0.13-0.89, p 0.02), exhausted CD8 (HR 0.29, 95%CI 0.09-0.97, p 0.04), and PD1 (HR 0.44, 95%CI 0.20-1.02, p 0.05). Conclusions: Analysis of RNA abundance signatures strongly suggests that there are important immune features that are associated with benefit from capecitabine in TNBC. However, analysis of RNA extracted from whole tumor sections lacks spatial discrimination. We anticipate that a more detailed, spatially-defined analysis of protein abundance, using the novel NanoString GeoMX platform, will provide more insights and define specific immune features associated with improved outcome. Additional results of GeoMX will be reported at the meeting. Clinical trial information: NCT00114816.
Phase-locking in post-processing for pulsating flames (2007)

A new approach to studying thermo-acoustically driven heat release fluctuations has been developed. By performing a phase correlation of the pulsation signal for each instant in time in post-processing, a number of advantages over the usual online processing technique are obtained: many frequencies can be analysed from the same data set allowing faster recording and introducing fewer errors than performing the phase correlation online. The method does not require complicated trigger and delay line setups and is most flexible. As an example of this technique, two different pulsation modes of a swirl combustor are resolved from only 300 chemiluminescence images. Further use of this method for a wide variety of applications is indicated.
A fiber-optic powered wireless sensor module made on elastomeric substrate for wearable sensors (2005)

We demonstrate an integrated sensor module that combines a photonic nano-porous sensor and a bias-free optical powered RF transducer. The sensor signal is encoded in the RF frequency ready for transmission. The entire sensor module does not include battery and is constructed with the flexible and biocompatible elastomeric polymer, PDMS. This technology holds promise for wearable sensors.
Mapping and interpreting biological information (1991)

article Mapping and interpreting biological information Share on Authors: Eric S. Lander Whitehead Institute for Biomedical Research, and Massachusetts Institute of Technology, Cambridge Whitehead Institute for Biomedical Research, and Massachusetts Institute of Technology, CambridgeView Profile , Robert Langridge Univ. of California, San Francisco Univ. of California, San FranciscoView Profile , Damian M. Saccocio Rensselaer Polytechnic Institute, Troy, NY Rensselaer Polytechnic Institute, Troy, NYView Profile Authors Info & Claims Communications of the ACMVolume 34Issue 11Nov. 1991 pp 32–39https://doi.org/10.1145/125490.125491Online:01 November 1991Publication History 33citation550DownloadsMetricsTotal Citations33Total Downloads550Last 12 Months5Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Video-rate high-resolution parallel optical coherence tomography (2002)

Parallel optical coherence tomography is demonstrated at video rate using a 58 by 58 smart-pixel detector array. A sample volume of 210x210x80 micrometers<SUP>3</SUP> (corresponding to 58x58x58 voxels) was imaged at 25 Hz. A femtosecond mode-locked Ti:Sapphire laser in combination with a free space Michelson interferometer was employed to achieve a 3 micrometer longitudinal resolution. We used 20x microscope objectives in both sample arm and reference arm and measured a 8 micrometer transverse resolution. The sensitivity of the system was 76 dB.
Structural Basis for Evolution of Product Diversity in Soybean Glutathione Biosynthesis (2009)

The redox active peptide glutathione is ubiquitous in nature, but some plants also synthesize glutathione analogs in response to environmental stresses. To understand the evolution of chemical diversity in the closely related enzymes homoglutathione synthetase (hGS) and glutathione synthetase (GS), we determined the structures of soybean (Glycine max) hGS in three states: apoenzyme, bound to gamma-glutamylcysteine (gammaEC), and with hGSH, ADP, and a sulfate ion bound in the active site. Domain movements and rearrangement of active site loops change the structure from an open active site form (apoenzyme and gammaEC complex) to a closed active site form (hGSH*ADP*SO(4)(2-) complex). The structure of hGS shows that two amino acid differences in an active site loop provide extra space to accommodate the longer beta-Ala moiety of hGSH in comparison to the glycinyl group of glutathione. Mutation of either Leu-487 or Pro-488 to an Ala improves catalytic efficiency using Gly, but a double mutation (L487A/P488A) is required to convert the substrate preference of hGS from beta-Ala to Gly. These structures, combined with site-directed mutagenesis, reveal the molecular changes that define the substrate preference of hGS, explain the product diversity within evolutionarily related GS-like enzymes, and reinforce the critical role of active site loops in the adaptation and diversification of enzyme function.
Surface-plasmon coupling in subwavelength periodic structures (2005)

Strong reemission of the surface plasmons through a single subwavelength aperture is mainly caused by in-phase coupling of the surface localized electromagnetic waves to irradiative modes by periodic groove structures. By introducing a linear chirping in the groove period, we enhance the coupling effect for focusing the reemitted light in near-field region. The linear chirping in the groove structures which have monotonically decreasing period, leads to focusing the reemitted light with the length, depth, and width of the focus in order of wavelength. We show numerically that the focusing ability is dramatically affected by amount of the linear chirping, and that efficient relaying of a diverging Gaussian beam to a photonic crystal waveguide can be achieved.
VARTM Process Modeling of Aerospace Composite Structures (2003)

A three-dimensional model was developed to simulate the VARTM composite manufacturing process. The model considers the two important mechanisms that occur during the process: resin flow, and compaction and relaxation of the preform. The model was used to simulate infiltration of a carbon preform with an epoxy resin by the VARTM process. The model predicted flow patterns and preform thickness changes agreed qualitatively with the measured values. However, the predicted total infiltration times were much longer than measured most likely due to the inaccurate preform permeability values used in the simulation.
Compaction of Commercially Pure Titanium Powder by Friction Powder Compaction Process (2012)

A new friction powder compaction (FPC) process is introduced for compacting commercially pure titanium powder. The FPC process is very simple and energy-efficient since it requires only a rotating tool plunged into an aluminum plate with a hole filled with titanium powder, and no external heat source is necessary. The sintering of the powder is mainly achieved by the friction heat and pressing load generated by the rotating tool in the aluminum plate and powder. The microstructure and Vickers hardness of the compacted titanium powder were investigated. It was shown that titanium powder was satisfactorily compacted by the FPC process.
Clinical Usefulness of the Glucose Concentration in the Subcutaneous Tissue - Properties and Pitfalls of Electrochemical Biosensors (1994)

Biosensors are miniaturized analytical tools which comprise a biological detection element providing specificity to the analyte, and a physical transducer which guarantees an output signal, e.g. an electric current the size of which is proportional to the concentration of the analyte. They provide the unique possibility of continuous in vivo monitoring. Glucosensors were in fact the first biosensors under study. Among them, the most advanced devices are measuring amperometrically the hydrogen peroxide generated in a stoichiometric relation to the prevailing glucose concentration during glucose oxidase-mediated glucose oxidation. They proved useful in commercially available glucose analyzers and in experimental subcutaneous monitoring. Here it is shown (a) that under steady state conditions the s.c. glucose concentration is nearly identical to that in blood, (b) that s.c. inserted glucose electrodes do mirror the intracorporal glucose concentration both under hypo-, normo-, and hyperglycaemic conditions with a clinically relevant accuracy, (c) that even stable feedback control of intracorporal glucose concentration is possible employing s.c. glucosensor signal as an input to automated insulin pump controller, and (d) that stable function of s.c. sensor is usually accomplished over intervals up to one day but in some cases applications over up to ten days could be realized. The underlying problem consists in an insufficient functional biostability which is a function of biocompatibility and size of the sensor, of its sterility, and of the permanent skin penetration. The latter is still required to get the device in place, to keep it in function, and to make use of the data under any condition.(ABSTRACT TRUNCATED AT 250 WORDS)
Drivers' Detection and Identification of Head-up versus Head-down Telltale Warnings in Automobiles (1995)

Previous automotive head-up display (HUD) research reported in the human factors literature has focused almost exclusively on the presentation of speed information. This paper, however, reports the results of a study which focused on telltale warning detection and identification. In this on-road study, eight younger (21 to 36 years) and eight older (63 to 72 years) drivers were tested. During a short familiarization drive, an unexpected brake telltale was presented up to four times in either a head-up or head-down display condition. The ability of drivers to detect (i.e., visually fixate upon) and identify (i.e., report) the brake telltale was assessed via self-reports and video analysis of the drivers’ eye movements in response to telltale onsets. Later in the study, drivers were explicitly instructed to perform various tasks, including telltale detection, under both display conditions. Detection rates for an expected brake telltale were analyzed. Results of the study suggest that drivers will detect and identify briefly presented telltale warnings sooner, and with greater probability, when they are presented on a HUD as opposed to a conventional head-down display.
Design Study of a Humidification Tower for the Advanced Humid Air Turbine System (2005)

The AHAT (advanced humid air turbine) system, which can be equipped with a heavy-duty, single-shaft gas turbine, aims at high efficiency equal to that of the HAT system. Instead of an intercooler, a WAC (water atomization cooling) system is used to reduce compressor work. The characteristics of a humidification tower (a saturator), which is used as a humidifier for the AHAT system, were studied. The required packing height and the exit water temperature from the humidification tower were analyzed for five virtual gas turbine systems with different capacities (1MW, 3.2MW, 10MW, 32MW and 100MW) and pressure ratios (π = 8, 12, 16, 20 and 24). Thermal efficiency of the system was compared with that of a simple cycle and a recuperative cycle with and without the WAC system. When the packing height of the humidification tower was changed, the required size varied for the three heat exchangers around the humidification tower (a recuperator, an economizer and an air cooler). The packing height with which the sum total of the size of the packing and these heat exchangers became a minimum was 1m for the lowest pressure ratio case, and 6m for the highest pressure ratio case.
Bacteriocins reduceCampylobacter jejunicolonization while bacteria producing bacteriocins are ineffective (2008)

Broiler chickens are widely considered an important source of human exposure to Campylobacter jejuni because of the high numbers found colonizing the chicken gut and the consequent contamination of processed carcasses.We hoped to intervene in C. jejuni gut colonization by using a defined probiotic. Chicken intestinal contents were screened for diverse bacterial isolates that manifested C. jejuni inhibition. These antagonistic bacteria were fed directly to chickens before or after C. jejuni challenge. The prophylactic probiotic treatments were effective only when very low challenge levels of C. jejuni were used. Otherwise, probiotic treatments failed to reduce C. jejuni colonization. Regardless of treatment, as birds further aged C. jejuni numbers soon approached the levels observed in the control birds. We sought an alternative approach, as commercial broilers may be exposed to infectious levels of C. jejuni at any time during production. Two of our most promising antagonistic isolates, Lactobacillus salivarius NRRL B-30514 and Paenibacillus polymyxa NRRL B-30509, were further studied for effectiveness in reducing C. jejuni in chickens. When 250 mg of purified bacteriocins (produced by these organisms)/kg feed were fed therapeutically to chickens colonized with C. jejuni, colonization was reduced by at least one million-fold. Treatments with viable probiotic bacterial cultures were ineffective in reducing C. jejun i in chickens, while bacteriocin treatment from these corresponding bacteria substantially reduced C. jejuni colonization in the live birds. Key words: bacteriocin, Campylobacter jejuni, colonization, probiotic, broiler chicken, competitive exclusion, Lactobacillus salivarius, Paenibacillus polymyxa