gebhart/patrepeval huggingface dataset:
Making a Case for Not Prescribing Antimuscarinic Drugs to Treat Overactive Bladder in Older Adults (2018)

No AccessJournal of UrologyJU Forum1 Apr 2019Making a Case for Not Prescribing Antimuscarinic Drugs to Treat Overactive Bladder in Older Adults Michael B. Chancellor and Toyohiko Watanabe Michael B. ChancellorMichael B. Chancellor More articles by this author and Toyohiko WatanabeToyohiko Watanabe More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.09.061AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Making a Case for Not Prescribing Antimuscarinic Drugs to Treat Overactive Bladder in Older Adults." The Journal of Urology, 201(4), pp. 676–677 References 1. : Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults. JAMA Neurol 2016; 73: 721. Google Scholar 2. : Anticholinergic drugs and risk of dementia: case-control study. BMJ 2018; 361: k1315. Google Scholar 3. : Long-term patterns of use and treatment failure with anticholinergic agents for overactive bladder. Clin Ther 2013; 35: 1744. Google Scholar 4. : Limitations of anticholinergic cycling in patients with overactive bladder (OAB) with urinary incontinence (UI): results from the CONsequences of Treatment Refractory Overactive bLadder (CONTROL) study. Int Urol Nephrol 2016; 48: 1029. Google Scholar 5. American Geriatrics Society 2015 Beers Criteria Update Expert Panel: American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc 2015; 63: 2227. Google Scholar Beaumont Health System, Oakland University William Beaumont School of Medicine, Rochester, Michigan andDepartment of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Japan © 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue 4April 2019Page: 676-677 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Michael B. Chancellor More articles by this author Toyohiko Watanabe More articles by this author Expand All Advertisement PDF downloadLoading ...
Ion channels based on bis-macrocyclic bolaamphiphiles: effects of hydrophobic substitutions (1998)

Four new bis-macrocyclic bolaamphiphiles were prepared to explore the effects of hydrophobic substitutions on ion transport. In bilayer vesicles the new compounds were remarkably similar to more hydrophilic derivatives prepared previously. Planar bilayer conductance experiments showed the new compounds induced an unique current-time signal consisting of a rapid rise time, followed by a slower decay time. Signal shape was cation dependent and was related to a modest selectivity between cations. Cation-anion selectivity was very high, approaching an ideal cation selectivity. One compound also showed voltage dependence of the signal shape and duration. Qualitative changes in signal shape, duration, and voltage dependence were provoked by variation in the electrolyte pH and by masking the head-group electrostatic interactions with low levels of barium ions. A model for the signal shape is proposed, involving a rapid current rise due to aggregate restructuring, followed by slower decay due to development of the local Donnan potential that results from the high cation-anion selectivity.Key words: ion channel, synthesis, bilayer membrane, bilayer clamp, mechanism.
Perkin 1 Abstracts: Natural Product Synthesis (2000)

R. Narquizian and J. Milne, J. Chem. Soc., Perkin Trans. 1, 2000, 6-xi DOI: 10.1039/B000732N
Basis for natural variation in sensitivity to 5-fluorouracil in mouse and human cells in culture. (1979)

Abstract Seven established human cell lines in vitro were, on the average, 8 times less sensitive to growth inhibition by 5-fluorouracil (FUra) than were eight mouse cell lines. Four of the human cell lines (U-cells, HeLa, KB, and Hep-2) and three mouse cell lines (S-180, MMT, and LM) were examined to clarify the basis of the different sensitivities. The K m 9s and V max 9s for the total cellular uptake of FUra were higher in the more sensitive (K m 300 to 500 µm; V max 110 to 140 pmol/min/mg cellular protein) than in the less sensitive cells (K m 30 to 120 µm; V max 10 to 70 pmol/min/mg cellular protein). At a fixed concentration of [2- 14 C]FUra (10 µm), the velocity of incorporation of the analog into acid-soluble and -insoluble material was up to 7 times more rapid in the more sensitive cells. The major acid-soluble metabolite was 5-fluorouridine triphosphate, which after 3 hr incubation with 10 µm FUra comprised 60 to 90% of soluble radioactivity and reached 43 to 130 µm in the cell water of the more sensitive and 11 to 24 µm in the less sensitive cells. No acidsoluble 5-fluorodeoxyuridine-5′-monophosphate was detected. There was no difference in the velocity of accumulation of unaltered FUra. This suggested that the conversion of FUra to nucleotides was slower in the less sensitive cells. Of three enzymes (uridine phosphorylase, thymidine phosphorylase, and FUra phosphoribosyltransferase), at least two had higher activities in the extracts of the more sensitive cells. There was no significant difference in fluorouridine kinase activity, while the activity of thymidine kinase was consistently higher in the less sensitive cells. These findings show that sensitivity to FUra of cells in vitro , whether of mouse or human origin, is associated with: ( a ) greater activity of enzymes responsible for converting FUra to 5-fluorodeoxyuridine, 5-fluorouridine, and 5-fluorouridine-5′-monophosphate; ( b ) lower activity of thymidine kinase; and ( c ) more rapid intracellular accumulation of acid-soluble FUra nucleotides and their incorporation into RNA.
AlInN/ GaN heterostructure field-effect transistors (2009)

We report on AlInN/GaN Heterostructure Field-Effect Transistors grown by MEMOCVD® technique [1] with virtually Ga-free AlInN layers. The layer thicknesses were 10 nm and 1 nm for AlInN and a thin AlGaN spacer layers, respectively. This technology allows for strain-free or strain-reduced structures for higher quality and performance nitride electronic devices. We obtained the two-dimensional electron gas (2DEG) sheet densities as high as 4.4×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">13</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> , and our estimates show that even higher values (up to 6×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">13</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> ) might be achievable. The electron mobility was over 500 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /Vs. As seen from Figure 1, the thickness of AlInN layer controls the sheet 2DEG density and, therefore, 2DEG sheet resistance. This allows for fabrication on the same wafer normally-on and normally-off HFETs and MOSHFETs with low resistive gate-source and gate-drain access regions. The high sheet density allowed us to achieve a very low contact resistance (0.073 Ω-mm, see Figure 2). To the best of our knowledge this is the lowest contact resistance reported so far for GaN HFETs.
Methanol reduces an organopalladium(II) complex to a palladium(I) hydride. Crystallographic characterization of a hydrido-bridged palladium complex (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethanol reduces an organopalladium(II) complex to a palladium(I) hydride. Crystallographic characterization of a hydrido-bridged palladium complexMoshe Portnoy, Felix Frolow, and David MilsteinCite this: Organometallics 1991, 10, 12, 3960–3962Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/om00058a007https://doi.org/10.1021/om00058a007research-articleACS PublicationsRequest reuse permissionsArticle Views671Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A comprehensive design and optimization of an offset strip-fin compact heat exchanger for energy recovery systems (2022)

Energy recovery in conventional thermal systems like power plants, refrigeration systems, and air conditioning systems has enhanced their thermodynamic and economic performance. In this regard, compact heat exchangers are the most employed for gas to gas energy recovery because of their better thermal performance. This paper presents an economic optimization of a crossflow plate-fin heat exchanger with offset strip fins. A detailed software-based numerical code for thermal, hydraulic, economic, and exergy analysis is developed for three fin geometries. Genetic Algorithm, parametric, and normalized sensitivity analyses are used to discover the most influential parameters to optimize the total cost. The parametric study showed that with the increase of mass flow rates and plate spacing, outlet stream cost and operating cost increased due to the rise in pressure drops. Finally, the optimization reduced the operational cost by ∼78.5%, stream cost by ∼64.5%, and total cost by ∼76.8%.
Network Theory of Antenna Arrays (2021)

Abstract The microwave network theory of antenna arrays improves on the classical array factor modeling approach by including in the analysis the effects of mutual coupling between array elements. Network theory allows numerical simulations of antenna arrays to be combined with network models for transmitter and receiver electronics to provide a full model for the signal and noise response of the system. The network theory framework provides definitions for active array figures of merit, such as aperture efficiency, receiving efficiency, and noise‐matching efficiency, and can be used to link the array system model with the analytical tools of array signal processing and statistically optimal beamformer design. An application is given to high‐sensitivity array feed receivers used for radio astronomy.
HMM Adaptation Using Statistical Linear Approximation for Robust Speech Recognition (2011)

Automatic Speech Recognition (ASR) systems, show degraded recognition performance when train and operate on mismatched environments. This mismatch can be caused due to different microphones, noise conditions, communication channels, acoustical environment etc. This work is motivated, in part, by the Distributed Speech Recognition (DSR) architecture. The DSR uses ASR server that provides speech recognition services to different devices that may operate in different environments (i.e. mobile devices). Thus, the ASR server must implement environment compensation techniques. The traditional ASR environment compensation techniques use filtering and noise masking, spectral subtraction and multi microphones array. These techniques are usually implemented in the ASR front end and aims to provide clean speech samples to the ASR engine. State of the art ASR systems use Hidden Markov Models (HMM) to represent the stochastic nature of the speech features. These statistical models achieves high recognition rate when trained and tested at the same environmental condition. To add noise robustness for these models, methods such as Maximum Likelihood Linear Regression (MLLR) and Parallel Model Combination (PMC) had been developed. These methods perform an adaptation of the ASR engine to better fit the recognition environment. The main drawback of these methods is there computational complexity and the need of large adaptation data, which makes them not suitable for real-time application. The environment compensation technique, presented in this chapter, is an extension of the Statistical Linear Approximation (SLA) method originally applied in the feature space to the model space. Using this environment compensation technique, new adapted HMMs set are created Using the clean speech HMMs and the noise model. The adapted HMMs are then used for the recognition of the degraded speech. The proposed robustness method is highly attractive for the Distributed Speech Recognition (DSR) architecture, since there is no impact on the Front End structure and neither on the ASR topology. Experiments, using this method, show high recognition rates in various noise conditions, close to the case of matched training (i.e. recognition and training performed in the same degraded environment).
Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia (2016)

Neuroinflammation increases GABAergic tone in the cerebellum by increasing GAT-3 membrane expression. This impairs motor coordination and learning in the Y maze. Sulforaphane could be a new therapeutic approach to improve cognitive and motor function in hyperammonemia, hepatic encephalopathy, and other pathologies associated with neuroinflammation by promoting microglia differentiation from M1 to M2.
PEG Modified Anticancer Drugs: Synthesis and Biological Activity (1996)

Three well known anticancer drugs, doxorubicin, methotrexate and paclitaxel (taxol), have been modified by the permanent attachment of poly(ethylene glycol)(PEG) and evaluated for in vitro cytotoxic activity against murine leukemias P388 and L1210. The relative potencies of the PEG derivatives suggest that modification of antitumor agents with this type of polymer yields compounds that are highly water soluble but less cytotoxic.
Optimal active suspension control based on a half-car model: an analytical solution (1992)

Simple yet, in practice, meaningful state-space formulations of the optimal suspension control problem for a half-car 2-D vehicle model are given. Using an efficient equivalent representation, a complete analytical solution of the related fourth-order linear quadratic problem was obtained. The problem structure and associated analytical results are used to deduce generic properties of the optimal solution, which in turn form a basis for global, centralized, and decentralized optimal suspension performance studies.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Ultrafast Graded Double Heterostructure p-i-n Photodiode (1991)

Efficient high bandwidth photodetectors are of great interest for use in optical communication, as well as in ultrafast measurement techniques. The shortest electrical pulses have been generated from photoconductors, although the quantum efficiency of the sub 10 ps devices has been too low for use in analog or digital transmission experiments. Bandwidths as large as 110 GHz 1 were obtained in GaAs Schottky barrier photodiodes. The shortest measured impulse response was reported by Wang et al. 2 who measured a photoresponse pulsewidth of 8.8 ps (of which 5.4 ps was attributed to the photodetector). In the long wavelength InGaAs/InP material system, p-i-n diodes have been reported with bandwidths in excess of 58 GHz 3,4 . Recently, Crawford et al. 5 reported the lowest measured impulse response of InGaAs/InP p-i-n photodiodes of 16 ps. In this case, the photodiode response was limited by the measurement system. We have since incorporated a graded double heterostructure into our device structures to minimize carrier diffusion and trapping effects. In this paper, we will present measurements on these photodiodes which have the shortest measured impulse response of any p-i-n or Schottky photodiode yet reported.
Pericardial Effusion Following Drain Removal after Percutaneous Epicardial Access for an Electrophysiology Procedure (2015)

Postoperative pericardial effusion requiring repeat access/drainage was relatively infrequent, occurring in 4.9% of patients shortly after epicardial procedures. While the majority occur early and therefore require close observation, some patients may present in a delayed manner.
Renin expression in renal proximal tubule. (1993)

Angiotensinogen, angiotensin-converting enzyme, and renin constitute the components of the renin-angiotensin system. The mammalian renal proximal tubule contains angiotensinogen, angiotensin-converting enzyme, and angiotensin receptors. Previous immunohistochemical studies describing the presence of renin in the proximal tubule could not distinguish synthesized renin from renin trapped from the glomerular filtrate. In the present study, we examined the presence of renin activity and mRNA in rabbit proximal tubule cells in primary culture and renin mRNA in microdissected proximal tubules. Renin activity was present in lysates of proximal tubule cells in primary culture. Cellular renin content in cultured proximal tubule cells was increased by incubation with 10(-5) M isoproterenol and 10(-5) M forskolin by 150 and 110%, respectively. In addition, renin transcripts were detected in poly(A)+ RNA from cultured proximal tubule cells by RNA blots under high stringency conditions. In microdissected tubules from normal rats, renin mRNA was not detectable with reverse transcription and polymerase chain reaction. However, in tubules from rats administered the angiotensinogen-converting-enzyme inhibitor, enalapril, renin was easily detected in the S2 segment of the proximal tubule. We postulate the existence of a local renin-angiotensin system that enables the proximal tubule to generate angiotensin II, thereby providing an autocrine system that could locally modulate NaHCO3 and NaCl absorption.
Cross-Fertilization of the French Territorial Model: The French General Review of Public Policies (RGPP) Program Review and the Reorganizations of the State at the Territorial Level (2010)

State reform at the territorial level (REATE – reforme de l’administration territoriale de l’Etat) undertaken in the framework of France’s RGPP (Revision generale des politiques publiques – General Review of Public Policies) Program Review, is the most far-reaching reorganization since 1964, affecting both the distribution of work between different parts of decentralized government and the hierarchical relationships between central, regional, and department administrations. This paper considers, however, whether it constitutes a genuinely unprecedented reform or merely follows on from previous initiatives: it seeks to distinguish between processes of institutional replication and processes of change. Two arguments are developed: firstly, that the RGPP has provided an appropriate framework to revive and broaden the territorial administration reform already underway since 2002; secondly, that the conflictual process through which the reform has been introduced has entailed a compromise that cross-fertilizes the traditional organization of state administration at the territorial level in an original way.
Assessment of the configuration of the posterior cells of the nematode embryo as potential phylogenetic marker (2009)

We have reconstructed the evolutionary history of an early developmental character by mapping the configuration of the posterior cells in the early embryo onto the SSU-based molecular phylogeny of Holterman (2006). We have analyzed the early embryonic development of 19 species, complemented with 20 species from the literature, covering representatives in each clade. We show that the Caenorhabditis elegans configuration, found in most species in clade III-X, is the ancestral state for these clades. alternative configurations arose inependently in clade IX, (Diploscapter coronatus), X (Halicephalobus gingivalis), XI (all investigated species) and XII (Meloidogyne incognita). A variable configuration of the posterior cells arose at least twice independently during nematode evolution, once in clade IX (D. coronatus) and once in an ancestor, shared by clade XI and XII and thus can be used as a phylogenetic marker to delineate these clades. Statistical tests based on our data-set show that the presence of a variable configuration is related to developmental tempo and egg shape.
A New Position Quality Metric for NR RAT Dependent OTDOA Positioning Methods (2019)

Release 9 specification of the Third Generation Partnership Project (3GPP) provided support to Observed Time Difference of Arrival (OTDOA) based positioning method for UE-Assisted mode using Long Term Evolution (LTE) Radio Access Technology (RAT). Evolving to release 16 specification it has been agreed by 3GPP consortium also to support UE-Based New Radio (NR), popularly known as 5G RAT dependent positioning method. UE-Based positioning methods will enable the device to calculate its location by using the Assistance Data (AD) that are transmitted by the Network. The AD may need to be broadcast and since the broadcast resource is constraint in terms of resources and physical size limit of broadcast channel, the AD should be selected carefully. The selection of data in the AD delivery would play a crucial role for the UE to calculate the location with high accuracy. In order to obtain high precision accuracy, the geometry in terms of UE location and the selection of beams would play an important role in NR. Further NR is expected to operate in high bandwidth spectrum where beam based transmission would be more common. Several beams may have to be used to get a focused coverage and it should be directed in various angles. Network should carefully select which beams to be used for the Position Reference Signal (PRS) transmission in order to mitigate interference and optimize the resources. The traditional Geometric Dilution of Precision (GDOP) metric which is based upon geometry between UE and the Transmission Points (TRPs) may not be sufficient as the beams may have different tilt/orientation. In this paper, we discuss the architecture and signaling of UE-Based DL RAT dependent OTDOA Positioning method. We exploit the NR Beam based angular information in selecting the cell sector or beams to be used for location calculation. We propose a new metric for the beam selection for the PRS transmission.
Isoelectronic Pt(ii)– and Au(iii)–N-heterocyclic carbene complexes: a structural and biological comparison (2018)

To differentiate the intrinsic biological activities displayed by Pt <italic>vs.</italic> Au reagents, a series of square planar carbene complexes were compared.