gebhart/patrepeval huggingface dataset:
RISE IN PLASMA GROWTH HORMONE IN RESPONSE TO EXOGENOUS LRH IN KLINEFELTER'S SYNDROME (1981)

In a group of sixteen patients with Klinefelter's syndrome (KS) aged from 2 years 8 months to 31 years, a study was made of the plasma growth hormone (hGH) response to LRH (50 micrograms/m2 i.v.; n=16), TRH (200 micrograms i.v.; n=14) and insulin-induced hypoglycaemia (0.1 u R.I,/kg i.v.; n=6). There was a rise in hGH following LRH from a level below 5 ng/ml during fasting to a level above 8 ng/ml (P less than 0.001) in nine (56.3%) of the sixteen patients tested; a similar response was found in only one of a control group of fifteen boys matched for age. TRH stimulation led to a rise in hGH in one of the fourteen KS patients tested, with none in the control group. Insulin-induced hypoglycaemia elicited a normal response of hGH in the six KS patients tested, from 1.8 +/- 0.7 to 16.5 +/- 3.7 ng/ml, (M +/- SD, P less than 0.001). Basal prolactin (PRL) levels were normal in the KS patients (9.4 +/- 4.1 ng/ml, M +/- SD) but the response to TRH stimulation was significantly higher (63.3 +/- 40 ng/ml; P less than 0.01) than that of the control group (30 +/- 15 ng/ml). Plasma gonadotrophin levels and the response to LRH stimulation were increased in all of the KS patients except those below the age of 13. Plasma TSH levels and the response to TRH stimulation as well as the levels of serum thyroxine were found to be normal in all the KS patients tested. The abnormal rise of hGH following LRH stimulation and of PRL following TRH stimulation suggests a disturbance in the neuroendocrine regulation mechanisms of these hormones in KS.
C3 inhibition with pegcetacoplan in subjects with paroxysmal nocturnal hemoglobinuria treated with eculizumab (2020)

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired, life-threatening hematologic disease characterized by chronic complement-mediated hemolysis and thrombosis. Despite treatment with eculizumab, a C5 inhibitor, 72% of individuals remain anemic. Pegcetacoplan (APL-2), a PEGylated C3 inhibitor, has the potential to provide more complete hemolysis control in patients with PNH. This open-label, phase Ib study was designed to assess the safety, tolerability, and pharmacokinetics of pegcetacoplan in subjects with PNH who remained anemic during treatment with eculizumab. Pharmacodynamic endpoints were also assessed as an exploratory objective of this study. Data are presented for six subjects in cohort 4 who received treatment for up to 2 years. In total, 427 treatment-emergent adverse events (TEAEs) were reported, 68 of which were possibly related to the study drug. Eight serious TEAEs occurred in two subjects; three of these events were considered possibly related to the study drug. Pegcetacoplan pharmacokinetic concentrations accumulated with repeated dosing, and steady state was reached at approximately 6-8 weeks. Lactate dehydrogenase levels were well controlled by eculizumab at baseline. Pegcetacoplan increased hemoglobin levels and decreased both reticulocyte count and total bilirubin in all six subjects. Improvements were observed in Functional Assessment of Chronic Illness Therapy Fatigue scores. Two subjects discontinued for reasons unrelated to pegcetacoplan. All four subjects who completed the study transitioned to pegcetacoplan monotherapy following eculizumab discontinuation and avoided transfusions. In this small study, pegcetacoplan therapy was generally well-tolerated, and resulted in an improved hematological response by achieving broad hemolysis control, enabling eculizumab discontinuation.
Temperature stable Pd ohmic contacts to p-type 4H-SiC formed at low temperatures (1999)

The formation of low resistivity Pd-based ohmic contacts to p-type 4H-SiC below 750/spl deg/C are reported herein. The electrical properties of the contacts were examined using I-V measurements and the transmission-line model (TLM) technique. Contact resistivity as a function of annealing was investigated over the temperature range of 600/spl deg/C-700/spl deg/C. The lowest contact resistivity (5.5/spl times/10/sup -5/ /spl Omega/cm/sup 2/) was obtained after annealing at 700/spl deg/C for 5 min. Atomic force microscopy of the as-deposited Pd layer showed a root-mean-square roughness of /spl sim/8 nm, while after annealing at 700/spl deg/C, agglomeration occurred, increasing the roughness to 111 nm. Auger electron spectroscopy depth profiles revealed that with annealing, interdiffusion had resulted in the formation of Pd-rich silicides. However, X-ray diffraction and Rutherford backscattering showed that the majority of the film was still (unreacted) Pd. The thermal stability and reliability of the Pd contacts were examined by aging and temperature dependence electrical tests. The contacts annealed at 700/spl deg/C were stable at prolonged heating at a constant temperature of 500/spl deg/C and they showed thermal stability in air at operating temperatures up to 450/spl deg/C. This stability was not found for contacts formed at lower temperatures of 600/spl deg/C or 650/spl deg/C.
ChemInform Abstract: Synthesis and Structure—Activity Relationships of Novel 2‐Amino Alkyl Chromones and Related Derivatives as σ Site‐Selective Ligands. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Flow Control for Unmanned Air Vehicles (2021)

The pervasiveness of unmanned air vehicles (UAVs), from insect to airplane scales, combined with active flow control maturity, has set the scene for vehicles that differ markedly from present-day configurations. Nano and micro air vehicles, with characteristic Reynolds numbers typically less than 10 5 , rely on periodically generated leading-edge vortices for lift generation, propulsion, and maneuvering. This is most commonly achieved by mechanical flapping or pulsed plasma actuation. On larger UAVs, with Reynolds numbers greater than 10 5 , externally driven and autonomous fluidic systems continue to dominate. These include traditional circulation control techniques, autonomous synthetic jets, and discrete sweeping jets. Plasma actuators have also shown increased technological maturity. Energy efficiency is a major challenge, whether it be batteries and power electronics on nano and micro air vehicles or acceptably low compressor bleed on larger UAVs. Further challenges involve the development of aerodynamic models based on experiments or numerical simulations, as well as flight dynamics models.
A universal structure for SRAM cell characterization (2010)

A universal test structure (UTS) for SRAM cell characterization is proposed and implemented in 65nm - 28nm technologies. The structure allows, for the first time, measurement of nearly all transistor and cell characteristics of an SRAM cell on silicon. It hence enables direct correlation among various measured transistor and cell characteristics, collection of intra-bit transistor mismatch data, and assessment of wafer level Vmin sensitivity on transistor characteristics. Measured data are presented.
Millimeter-wave radar sensing of airborne chemicals (2001)

This paper discusses the development of a millimeter-wave radar chemical sensor for applications in environmental monitoring and arms-control treaty verification. The purpose of this paper is to investigate the use of fingerprint-type molecular rotational signatures in the millimeter-wave spectrum to sense airborne chemicals. The millimeter-wave sensor, operating in the frequency range of 225-315 GHz, can work under all weather conditions and in smoky and dusty environments. The basic configuration of the millimeter-wave sensor is a monostatic swept-frequency radar that consists of a millimeter-wave sweeper, a hot-electron bolometer or Schottky barrier detector, and a corner-cube reflector. The chemical plume to be detected is situated between the transmitter/detector and reflector. Millimeter-wave absorption spectra of chemicals in the plume are determined by measuring the swept-frequency radar return signals with and without the plume in the beam path. The problem of pressure broadening, which hampered open-path spectroscopy in the past, has been mitigated in this paper by designing a fast sweeping source over a broad frequency range. The heart of the system is a backward-wave oscillator (BWO) tube that can be tuned over 220-350 GHz. Using the BWO tube, we built a millimeter-wave radar system and field-tested it at the Department of Energy Nevada Test Site, Frenchman Flat, near Mercury, NV, at a standoff distance of 60 m, The millimeter-wave system detected chemical plumes very well; detection sensitivity for polar molecules such as methylchloride was down to 12 ppm for a 4-m two-way pathlength.
A PROSPECTIVE STUDY ON THE USE OF WATER‐SOLUBLE CONTRAST FOLLOW‐THROUGH RADIOLOGY IN THE MANAGEMENT OF SMALL BOWEL OBSTRUCTION (1996)

Urografin follow-through examination is a safe procedure; using 4 h as the cut-off it is highly predictive of the outcome in small bowel obstruction in patients with or without previous abdominal operation.
Experimental Study of In-line Nonlinearity Mitigation for a 400 Gb/s Dual-Carrier Superchannel with Joint Reception Using a Waveband-Shift-Free OPC (2022)

We experimentally study waveband-shift-free optical phase conjugation (OPC) of a 400-Gb/s dual-carrier superchannel and discuss the effectiveness of the OPC for multi-channel nonlinear mitigation. After joint reception of the 31.44 GBd-PDM-16QAM sub-carriers after 800-km transmission, we achieve about 0.7-dB Q <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> -factor nonlinearity mitigation improvement.
High-k Organic, Inorganic, and Hybrid Dielectrics for Low-Voltage Organic Field-Effect Transistors (2009)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTHigh-k Organic, Inorganic, and Hybrid Dielectrics for Low-Voltage Organic Field-Effect TransistorsRocío Ponce Ortiz, Antonio Facchetti*, and Tobin J. Marks*View Author Information Department of Chemistry and the Materials Research Center, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208* To whom correspondence should be addressed. E-mail: [email protected] (A.F.); [email protected] (T.J.M.).Cite this: Chem. Rev. 2010, 110, 1, 205–239Publication Date (Web):October 23, 2009Publication History Received31 March 2009Published online23 October 2009Published inissue 13 January 2010https://pubs.acs.org/doi/10.1021/cr9001275https://doi.org/10.1021/cr9001275review-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views16679Altmetric-Citations791LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Hydrocarbons,Insulators,Layers,Oxides Get e-Alerts
The KnowRef Coreference Corpus: Removing Gender and Number Cues for Difficult Pronominal Anaphora Resolution (2019)

We introduce a new benchmark for coreference resolution and NLI, KNOWREF, that targets common-sense understanding and world knowledge. Previous coreference resolution tasks can largely be solved by exploiting the number and gender of the antecedents, or have been handcrafted and do not reflect the diversity of naturally occurring text. We present a corpus of over 8,000 annotated text passages with ambiguous pronominal anaphora. These instances are both challenging and realistic. We show that various coreference systems, whether rule-based, feature-rich, or neural, perform significantly worse on the task than humans, who display high interannotator agreement. To explain this performance gap, we show empirically that state-ofthe art models often fail to capture context, instead relying on the gender or number of candidate antecedents to make a decision. We then use problem-specific insights to propose a data-augmentation trick called antecedent switching to alleviate this tendency in models. Finally, we show that antecedent switching yields promising results on other tasks as well: we use it to achieve state-of-the-art results on the GAP coreference task.
Kinetics of successive seeding of monodisperse polystyrene latexes. II. Azo initiators with and without inhibitors (1986)

Abstract Oil soluble azo initiators in combination with water soluble inhibitors were used to extend the particle size limit in studies of the kinetics of successive seeding of monodisperse polystyrene latexes. Monodisperse latexes were prepared up to 2.5 μm in diam using 4.0 m M AMBN and 14.5 m M hydroquinone with a constant 15% emulsifier (Aerosol–MA) surface coverage throughout the seven step sequence. The polymerization kinetics were measured in a piston/cylinder dilatometer designed for microgravity experiments. The Interval III kinetics were dominated by the gel effect although these were affected by the nature of the inhibitor. In general, the overall polymerization rate decreased with increasing particle size (decreasing N p ) up to a size of about 1 μm. Thereafter, the kinetics were independent of these variables, exhibiting Smith‐Ewart Case 3 (bulk) kinetics. The initiator efficiencies were found to be of the order of 10%, considerably lower than reported for bulk polymerizations.
Automatic detection of calcium phosphate deposit plugs at the terminal ends of kidney tubules (2019)

Kidney stones are a common urologic condition with a high amount of recurrence. Recurrence depends on a multitude of factors the incidence of precursors to kidney stones, plugs, and plaques. One method of characterising the stone precursors is endoscopic assessment, though it is manual and time-consuming. Deep learning has become a popular technique for semantic segmentation because of the high accuracy that has been demonstrated. The present Letter examined the efficacy of deep learning to segment the renal papilla, plaque, and plugs. A U-Net model with ResNet-34 encoder was tested; the Letter examined dropout (to avoid overtraining) and two different loss functions (to address the class imbalance problem. The models were then trained in 1666 images and tested on 185 images. The Jaccard-cross-entropy loss function was more effective than the focal loss function. The model with the dropout rate 0.4 was found to be more effective due to its generalisability. The model was largely successful at delineating the papilla. The model was able to correctly detect the plaques and plugs; however, small plaques were challenging. Deep learning was found to be applicable for segmentation of an endoscopic image for the papilla, plaque, and plug, with room for improvement.
Bioequivalence (2016)

This Glossary of Terms Related to Pharmaceutics is needed by practitioners in the field of pharmaceutics as this field fulfills an important and crucial role, different from the roles of other scientific disciplines involved in the drugmaking process. The glossary contains 168 definitions used in pharmaceutics. These are related to various aspects of this discipline, such as: (1) physicochemical characterization of pharmaceutical preparations and the active ingredients they contain; (2) unit operations used in the practice of pharmaceutics; (3) terms related to the various dosage forms; (4) terms related to the various modes and routes of drug delivery; (5) terms used in pharmacokinetics and biopharmaceutics in general; and additional miscellaneous terms. The field of pharmaceutics itself is of a multidisciplinary nature as its practitioners come from a variety of disciplines, such as chemistry or various biological sciences, thus a glossary containing authoritative definitions would be useful for them. The terms used in pharmaceutics are rarely covered by existing glossaries, and in the cases they are, their definitions are often inappropriate for the field of pharmaceutics and require new or modified definitions to better fit the new context.
Device Activity and Embedded Information Bit Detection Using AMP in\n Massive MIMO (2017)

Future cellular networks will support a massive number of devices as a result\nof emerging technologies such as Internet-of-Things and sensor networks.\nEnhanced by machine type communication (MTC), low-power low-complex devices in\nthe order of billions are projected to receive service from cellular networks.\nContrary to traditional networks which are designed to handle human driven\ntraffic, future networks must cope with MTC based systems that exhibit sparse\ntraffic properties, operate with small packets and contain a large number of\ndevices. Such a system requires smarter control signaling schemes for efficient\nuse of system resources. In this work, we consider a grant-free random access\ncellular network and propose an approach which jointly detects user activity\nand single information bit per packet. The proposed approach is inspired by the\napproximate message passing (AMP) and demonstrates a superior performance\ncompared to the original AMP approach. Furthermore, the numerical analysis\nreveals that the performance of the proposed approach scales with number of\ndevices, which makes it suitable for user detection in cellular networks with\nmassive number of devices.\n
OFDMA Mobile Broadband Communications: A Systems Approach (2013)

We have investigated the biochemical mechanism of tumor necrosis factor (TNF)-alpha-induced release of plasminogen activator inhibitor-1 (PAI-1) from human umbilical vein endothelial cells (HUVEC). Treatment of HUVEC with TNF-alpha for 3 h resulted in a 2. 8-fold increase in the PAI-1 release compared with control. The increase in PAI-1 release was accompanied by a 133% increase in the intracellular acidic sphingomyelinase (SMase) activity. High-performance liquid chromatographic (HPLC) analysis revealed that the intracellular ceramide levels increased to 126% of the control (P<0.05), but the contents of membranous ceramide remained unaltered. We have previously shown that a cell-permeable ceramide analog, N-acetylsphingosine (C2-ceramide) enhances the PAI-1 release from HUVEC. Here, N-acetylsphinganine (C2-dihydroceramide) was found to specifically suppress both C2-ceramide- and TNF-alpha-induced increase in PAI-1 release from HUVEC without affecting the control PAI-1 release. Treatment of HUVEC with staphylococcal SMase that may mimic the activation of the membranous neutral SMase also increased the PAI-1 release. The increase in PAI-1 release by this mechanism was suppressed by a cyclooxygenase inhibitor, aspirin, whereas the inhibitor did not affect TNF-alpha-induced increase in PAI-1 release. Taken together, these findings suggest that TNF-alpha prominently utilizes the lysosomal acidic SMase-ceramide signaling pathway in the induction of PAI-1 release from HUVEC.
A Reconfigurable Optical Demultiplexer based on a MEMS Deformable Blazed Grating (2006)

The operation of a cyclic reconfigurable optical wavelength multiplexer/demultiplexer based on a micromachined tunable blazed grating (TBG) is introduced and a 1times3 demultiplexer is experimentally demonstrated in the C-band
Supplemental - Three-Dimensional Liquid-Vapor Interface Reconstruction from High-Speed Stereo Images during Pool Boiling (2019)

Supplemental Material
Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt (2007)

Sanguinarine is a benzophenanthridine alkaloid that is derived from the root of Sanguinaria canadensis and other poppy fumaria species, and is known to have antimicrobial, antiinflammatory and antioxidant properties. This study investigated the possible mechanisms through which sanguinarine exerts its antiproliferative action in cultured C6 rat glioblastoma cells. The exposure of C6 cells to sanguinarine resulted in growth inhibition and the induction of apoptosis in a dose-dependent manner, as measured by the MTT assay, fluorescence microscopy, agarose gel electrophoresis and annexin-V-based assay. The sanguinarine treatment induced the proteolytic activation of caspases and ICAD/DFF45, which was associated with the modulation of the Bcl-2 family, concomitant degradation of poly(ADP ribose) polymerase and phospholipase C-gamma1 protein, and DNA fragmentation. z-DEVD-fmk, a caspase-3-specific inhibitor, blocked poly(ADP ribose) polymerase degradation, DNA fragmentation and increased the survival rate of sanguinarine-treated C6 cells. Moreover, the activity of extracellular signal-regulated kinase and Akt was downregulated in sanguinarine-treated cells, and PD98059, a specific extracellular signal-regulated kinase inhibitor, and phosphatidylinositol 3'-kinase/Akt inhibitors, LY294002 and wortmanin, sensitized the cells to sanguinarine-induced apoptosis, indicating that the downregulation of the extracellular signal-regulated kinase and Akt signaling pathway may play a key role in sanguinarine-induced apoptosis in C6 cells.
Global Photocurrent Generation in Phototransistors Based on Single‐Walled Carbon Nanotubes toward Highly Sensitive Infrared Detection (2019)

Abstract Because of their cost‐effective synthesis and appropriate bandgap opening by various mechanisms, single‐walled carbon nanotubes (SWCNTs) exhibit significant promise for highly efficient near‐infrared photodetection. In this work, the first investigation of manipulating the electrode contact and exciton effect is performed on photocurrent generation of SWCNT transistors by separately depositing Cr or Pd as symmetric source/drain electrodes. Two different photoconducting behaviors of the devices, namely localized and global photocurrent generations, are then observed, where these effects are attributed to thermally assisted tunneling at the 1D‐SWCNTs/3D‐metal contact. A phototransistor with global photocurrent generation is demonstrated having a typical photoconductive effect with a responsivity of 2 A W −1 at λ = 785 nm and a fast rise (decay) time of ≈7.35 µs (11.8 µs). However, the corresponding optical response at 2000 nm is still weak due to low incident photon energy and large exciton binding energy. By further spin coating PbS quantum dots onto the SWCNTs channel, the optical response can be greatly enhanced for 2000 nm irradiation. All these results can not only illustrate the photoresponse of SWCNTs but also indicate that photogating plays a crucial role in these devices, providing valuable insights for the performance enhancement.