gebhart/patrepeval huggingface dataset:
Polyoxopalladates Encapsulating Yttrium and Lanthanide Ions, [XIIIPdII12(AsPh)8O32]5− (X=Y, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) (2010)

A series of novel yttrium- and lanthanide-containing heteropolyoxopalladates have been prepared and isolated as hydrated sodium salts, Na(5)[X(III)Pd(II)(12)(AsPh)(8)O(32)]y H(2)O (X=Y (1), Pr (2), Nd (3), Sm (4), Eu (5), Gd (6), Tb (7), Dy (8), Ho (9), Er (10), Tm (11), Yb (12), Lu (13); y=15-27). The polyanions [X(III)Pd(II)(12)(AsPh)(8)O(32)](5-) consist of a cuboid framework of twelve Pd(II) ions with eight phenylarsonate heterogroups located at the vertices and a central guest ion X. The compounds 1-13 have been prepared in a simple one-pot self-assembly reaction of Pd(CH(3)COO)(2), phenylarsonic acid and the respective salt of the element X in 0.5 M aqueous sodium acetate solution (pH 6.9), and characterized in the solid state by single-crystal X-ray diffraction, elemental and thermogravimetric (TGA) analyses, and IR spectroscopy. It was demonstrated that small, medium, and also large lanthanide ions can be incorporated in the center of the novel heteropolypalladate [X(III)Pd(II)(12)(AsPh)(8)O(32)](5-). The Ln-O bond lengths follow the expected trend decreasing from left to right in the lanthanide series. This indicates that the {Pd(II)(12)O(32)} shell can adjust to the coordination requirements of the encapsulated guest cation. Compounds 3 and 5 were selected for electrochemical studies. Their cyclic voltammetry in a lithium acetate buffer at pH 5.9 showed a Pd(0) deposition process on the glassy carbon electrode surface. Coulometry indicated that all Pd(II) centers were reduced to Pd(0). The film was stable and could be taken out of the deposition medium and characterized in pure pH 5.9 buffer. Magnetic susceptibility and EPR measurements were carried out on 5 and 6. The former was confirmed to be diamagnetic and the latter strongly paramagnetic with a S=7/2 ground state. DFT calculations for some of the polyoxometalates have been also performed.
A Practical Titanium-Catalyzed Synthesis of Bicyclic Cyclopentenones and Allylic Amines (1996)

A practical titanium-catalyzed synthesis of bicyclic cyclopentenones and allylic amines is described. The process converts enyne substrates to iminocyclopentenes using 10 mol % of the air- and moisture-stable precatalyst Cp(2)TiCl(2) in the presence of n-BuLi and triethylsilyl cyanide. The resulting iminocyclopentenes can be hydrolyzed to cyclopentenones in good yields or reduced to allylic silylamines with Red-Al or DIBALH. Treatment of the crude silylamines with acetyl chloride allows isolation of allylic amides in excellent yields.
Spherical Lactic Acid Bacteria Activate Plasmacytoid Dendritic Cells Immunomodulatory Function via TLR9-Dependent Crosstalk with Myeloid Dendritic Cells (2012)

Plasmacytoid dendritic cells (pDC) are a specialized sensor of viral and bacterial nucleic acids and a major producer of IFN-α that promotes host defense by priming both innate and acquired immune responses. Although synthetic Toll-like receptor (TLR) ligands, pathogenic bacteria and viruses activate pDC, there is limited investigation of non-pathogenic microbiota that are in wide industrial dietary use, such as lactic acid bacteria (LAB). In this study, we screened for LAB strains, which induce pDC activation and IFN-α production using murine bone marrow (BM)-derived Flt-3L induced dendritic cell culture. Microbial strains with such activity on pDC were absent in a diversity of bacillary strains, but were observed in certain spherical species (Lactococcus, Leuconostoc, Streptococcus and Pediococcus), which was correlated with their capacity for uptake by pDC. Detailed study of Lactococcus lactis subsp. lactis JCM5805 and JCM20101 revealed that the major type I and type III interferons were induced (IFN-α, -β, and λ). IFN-α induction was TLR9 and MyD88-dependent; a slight impairment was also observed in TLR4(-/-) cells. While these responses occurred with purified pDC, IFN-α production was synergistic upon co-culture with myeloid dendritic cells (mDC), an interaction that required direct mDC-pDC contact. L. lactis strains also stimulated expression of immunoregulatory receptors on pDC (ICOS-L and PD-L1), and accordingly augmented pDC induction of CD4(+)CD25(+)FoxP3(+) Treg compared to the Lactobacillus strain. Oral administration of L. lactis JCM5805 induced significant activation of pDC resident in the intestinal draining mesenteric lymph nodes, but not in a remote lymphoid site (spleen). Taken together, certain non-pathogenic spherical LAB in wide dietary use has potent and diverse immunomodulatory effects on pDC potentially relevant to anti-viral immunity and chronic inflammatory disease.
Photophysical, photochemical, and electrochemical properties of mononuclear and dinuclear ruthenium(II) complexes containing 2,2'-bipyridine and the 3,5-bis(pyridin-2-yl)-1,2,4-triazolate ion (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotophysical, photochemical, and electrochemical properties of mononuclear and dinuclear ruthenium(II) complexes containing 2,2'-bipyridine and the 3,5-bis(pyridin-2-yl)-1,2,4-triazolate ionFrancesco Barigelletti, Luisa De Cola, Vincenzo Balzani, Ronald Hage, Jaap G. Haasnoot, Jan Reedijk, and Johannes G. VosCite this: Inorg. Chem. 1989, 28, 24, 4344–4350Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://pubs.acs.org/doi/10.1021/ic00323a013https://doi.org/10.1021/ic00323a013research-articleACS PublicationsRequest reuse permissionsArticle Views380Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
MAPK7 Regulates EMT Features and Modulates the Generation of CTCs (2015)

Suppression of MAPK7 induces epithelial markers, reduces generation of circulating tumor cells and appearance of lung metastases.
Vital Capacity Reservoir and Online Measurement of Childhood Nitrosopnea Are Linearly Related: Clinical Implications (1999)

Hypernitrosopnea, a robust marker for childhood asthma, is measured reproducibly in mixed vital capacity (VC) expirates. Recent guidelines for measurement of expired nitric oxide (NO) in adults have favored use of an online (OL), flow-dependent technique. We compared VC and OL NO measurements in 14 asthmatic and 11 control children 5 through 18 yr of age. After spirometry, subjects breathed both into an open-ended reservoir (20 cm H2O resistance) and into a tedlar bag (VC maneuver). End-expiratory pressure > 5 cm H2O was continuously maintained during VC measurements, and the velum remained shut. Eight additional children (24% of total number of subjects) were unable reproducibly to perform the OL measurement at constant flow (six asthmatics; two control children). For subjects able to perform the OL technique, OL and VC NO measurements were linearly related (r2 = 0.88). In children, VC NO assays are reproducible, sensitive in identifying asthma, and portable. Additionally, we have shown that (1) not all children are able to perform OL measurements, and (2) VC measurements vary linearly with OL measurements. These findings suggest that there may not be compelling reason to favor OL over VC measurements for hypernitrosopnea in children with asthma.
A novel laccase with urate oxidation activity from Lysobacter sp. T-15 (2010)

A unique urate-oxidizing enzyme was identified in a bacterium, strain T-15. Based on its phylogenetic, physiological and biochemical properties, strain T-15 was deemed to be a novel species within the genus Lysobacter. The enzyme expressed in Lysobacter sp. T-15 was composed of 592 amino acids and contained four consensus copper-binding sites, and the recombinant enzyme was, at least in this study, speculated to have three Cu ions per subunit. The primary structure of the enzyme was 33% identical to Marinomonas mediterranea polyphenol oxidase, but it showed no significant similarity to any known urate oxidase. With urate as the substrate, the catalytic efficiency (k(cat)/K(m)) of recombinant enzyme was 4.0 × 10(2) s(-)(1)mM(-)(1), and it was not inhibited by xanthine, a strong urate oxidase inhibitor. The enzyme also showed activity toward 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid), 2,6-dimethoxyphenol and bilirubin, with catalytic efficiencies of 4.9 × 10(2), 1.1 × 10(2) and 3.6 × 10(3) s(-)(1)mM(-)(1), respectively. We deemed the enzyme would be a member of laccase from its broad substrate specificity. However, typical laccase and other multi-copper oxidases such as bilirubin oxidase and ascorbate oxidase seldom exhibit urate oxidation activity. These results would expand the laccase substrate range to include urate.
Optimization of platelet-rich plasma and its effects on the recovery of erectile function after bilateral cavernous nerve injury in a rat model (2013)

Platelet-rich plasma (PRP) containing autologous growth factors is applied in regenerative medicine, but the lack of an optimized PRP preparation protocol causes unstable therapeutic effects. The aim of this study was to optimize the PRP preparation method and compare the effects of PRP from different preparation methods in restoration of erectile function in a rat model. The in vivo experiments used Sprague-Dawley male rats (n = 24), which were randomly divided into four groups of equal numbers: group I underwent sham operation, while the remaining three groups underwent bilateral CN crush. Crush injury groups were treated at the time of injury with an application of general PRP, optimized PRP [with the largest amount of platelet-derived growth factor (PDGF)-AB] or normal saline-only injection in the corpus cavernosum, respectively. Four weeks later, erectile function was assessed by CN electrosimulation, and penile tissue was collected for histology. Results demonstrated that in the PRP group prepared with the ACD-A anticoagulant, chitosan and incubated at -20°C for 15 days had the largest amount of PDGF-AB and showed a synergistic effect on release (p < 0.05). Functional outcome measurement and immunofluorescence staining for the dorsal nerve revealed that improvement after bilateral CN injury occurred in the optimized PRP group (p < 0.05). It was concluded that optimized PRP with a high level of growth factors was more stable, and its injection into the corpus cavernosum facilitated recovery of erectile function. Copyright © 2013 John Wiley & Sons, Ltd.
Power Optimization for SRAM and Its Scaling (2007)

With technology scaling, there is a strong demand for smaller cell size, higher speed, and lower power in SRAMs. In addition, there are severe constraints for reliable read-and-write operations in the presence of increasing random variations that significantly degrade the noise margin. To understand these tradeoffs clearly and find a power-delay optimal solution for scaled SRAM, sequential quadratic programming is applied for optimizing 6-T SRAM for the first time. The use of analytical device models for transistor currents and formulate all the cell-operation requirements as constraints in an optimization problem. Our results suggest that, for optimal SRAM cell design, neither the supply voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dd</sub> ) nor the gate length (L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> ) scales, due to the need for an adequate noise margin amid leakage and threshold variability and relatively low dynamic activity of SRAM. This is true even with technology scaling. The cell area continues to scale despite the nonscaling gate length (L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> ) with only a 7% area overhead at the 22-nm technology node as compared to simple scaling, at which point a 3-D structure is needed to continue the area-scaling trend. The suppression of gate leakage helps to reduce the power in ultralow-power SRAM, where subthreshold leakage is minimized at the cost of increase in cell area
Microglia show distinct tau associated subpopulations along tau spreading in human Alzheimer’s disease (2023)

Abstract Background In Alzheimer’s disease (AD) progression, amyloid beta load uniformly increases across the brain cortex, while neurofibrillary tangles progressively spread in a stereotypical pattern from entorhinal to visual cortex. AD is known to have a strong genetic link to microglia and recently, expression profiling at single cell resolution has identified disease‐associated microglia populations with differential amyloid‐beta vs. tau pathology association in human AD brain. However, prior human studies focusing on microglia included a limited number of donors and/or cells per donor, and how microglial transcriptomes change with progression of tau pathology remains largely unknown. Method Using single nuclei RNA sequencing, we profiled 337,512 microglia from 32 donors across 4 pathology groups (no to severe pathology) and five brain regions along the tau spreading pathway (entorhinal cortex, Brodmann Area 20, Brodmann Area 46, secondary visual cortex, and primary visual cortex) to investigate their cellular heterogeneity as a function of disease progression. Phospho‐Tau231 and HT7‐HT7 aggregated tau levels of adjacent tissue were assessed for quantification of tau pathology. Result We confirmed previously described microglial populations across all profiled regions and identified cluster associations with tau levels, which mirrored the expected stereotypical progression across brain regions. Integrative analysis showed high similarity of microglia subtypes across regions, but interestingly also revealed entorhinal cortex and late tau pathology enriched clusters. Genes upregulated in early vs. late tau‐affected regions at severe pathology stage, but not in healthy brain, were found to be enriched in DNA repair and replication processes as well as immune response activation, while downregulated genes corresponded to glial cell differentiation and gliogenesis. Conclusion This study constitutes a high‐quality resource of microglia phenotypes in a previously unmet sample size with regard to both donors and cells per donor, well characterized by quantitative readouts for tau pathology association across tau spreading regions. We foresee this study will contribute to a better understanding of how microglial phenotypes can be targeted during the progression of tau pathology in AD, while further work is required to distinguish causality from consequence.
Composite Right-Left Handed Metamaterial ultra-wideband antenna (2009)

In this paper, two novel ultra-wideband (UWB) antenna designs based on Composite Right-Left Handed (CRLH) Metamaterial (MTM) structures are elaborated. With CRLH MTM technology embedded, the proposed UWB antenna designs present best in class radiation bandwidth, efficiency, radiation pattern and polarization. All great figures of merits have been achieved based on ultra compact sized PCB antenna structures with convenient integration solution.
Immunogenicity and safety of three consecutive production lots of the non replicating smallpox vaccine MVA: A randomised, double blind, placebo controlled phase III trial (2018)

ClinicalTrials.gov NCT01144637.
Membrane Peeling-Induced Retinal Alterations on Intraoperative OCT in Vitreomacular Interface Disorders From the PIONEER Study (2015)

Significant subclinical retinal architectural changes occur during membrane peeling for VMI conditions. Differences in surgical instruments may impact these architectural alterations.
Inhibition of microglial neurotoxicity by ethanol extract of Artemisia asiatica Nakai (2007)

Artemisia asiatica Nakai has been used for the treatment of infections and inflammatory disorders in traditional Oriental medicine. Previously, an ethanol extract of A. asiatica has been shown to exert antioxidative and antiinflammatory activities and to exhibit protective effects against experimentally induced damage in the gastrointestinal system, liver and pancreas. This study examined whether the ethanol extract of A. asiatica affects inflammatory activation of microglia in the central nervous system, and whether the antiinflammatory activity of A. asiatica is related to neuroprotective effects. The extract of A. asiatica inhibited inflammatory activation of mouse microglial cells as determined by the production of nitric oxide and the expression of inducible nitric oxide synthase and inflammatory cytokine. The extract also protected nerve growth factor-differentiated PC12 cells against microglial cytotoxicity, indicating that the ethanol extract of A. asiatica may be neuroprotective by inhibiting microglial neurotoxicity.
Controlling nanoscale morphology in switchable PDLC gratings (1998)

Gratings formed by anisotropic phase separation of liquid crystals how tremendous promise for switchable optical elements. Formation of useful gratings is linked to the control of the resulting nano-scale morphologies. In an attempt to decrease scatter and improve the electro-optic properties of polymer-dispersed liquid crystal volume transmission gratings were have evaluated the result of altering the relative concentrations of the components in the pre-polymer mixture. Discussion is made concerning the expected effects on polymerization and phase separation and how these changes are reflected in the film morphologies and electro-optical properties. Initial results indicate that changes in the concentration of co-initiator, chain extender, and effective monomer functionality have a significant effect on the size and shape of the LC domains at constant LC loading.
Effects of Nonsteroidal Anti-Inflammatory Drugs on Bone Formation and Soft-Tissue Healing (2004)

Nonsteroidal anti-inflammatory drugs continue to be prescribed as analgesics for patients with healing fractures even though these drugs diminish bone formation, healing, and remodeling. Inhibition of bone formation can be clinically useful in preventing heterotopic ossification in selected clinical situations. In this regard, naproxen may be more efficacious than the traditional indomethacin, and short-term administration is as effective as long-term. When fracture healing or spine fusion is desired, nonsteroidal anti-inflammatory drugs should be avoided. Some nonsteroidal anti-inflammatory drugs have a positive effect on soft-tissue healing; they stimulate collagen synthesis and can increase strength in the early phases of repair during skin and ligament healing. Cyclooxygenase-2 inhibitors have an adverse effect on bone healing and may have an adverse effect on ligament healing. Therefore, further investigation is necessary to confirm that traditional nonsteroidal anti-inflammatory drugs may be preferable for the healing of collagenous tissues.
Supplementary Figure S7 from Leukemia Cell-Rhabdovirus Vaccine: Personalized Immunotherapy for Acute Lymphoblastic Leukemia (2023)

&lt;p&gt;Supplementary Figure S7 - PDF file 1183K, UV-treated apoptotic and pressure-disrupted necrotic L1210 cells used for specific vaccine preparations&lt;/p&gt;
Sensor fault detection in vehicle lateral control systems via switching kalman filtering (2005)

Vehicle lateral control for automated highway systems (AHSs) is concerned with lane keeping and lane changing. It is of critical importance for safe highway operations; it must have fault tolerant capability in order to maintain stability in the event of malfunction of its components. In this paper, we investigate detection, isolation and accommodation of sensor faults. We propose a stochastic framework to which switching Kalman filtering and the EM algorithm are applied to detect faulty sensors and achieve good state estimation. With prior knowledge about the sensor failure modes, multiple sensors can be integrated into the framework, and the single failure assumption is no longer required. Simulations show that the sensor faults are detected immediately after their occurrences. Stability and performance are observed to be satisfactory in the event of sensor failures.
Consensus- based decentralization of interior point methods for heterogeneous networks energy saving (2011)

In this paper, we propose a new decentralized consensus-based energy saving technique that improves the energy efficiency of a cellular network, with a focus on femto base station networks. The energy saving is obtained by a log barrier optimization on the sum transmit power of the network with a long-term or short-term coverage constraint for each cell. The common coordination parameter of the log-barrier method is approximated at each node by the result of a consensus algorithm, which allows for tracking the topology variations in a fully decentralized fashion. Simulation shows that the proposed technique doubles the energy saving efficiency of the centralized energy saving.
Photoactivated Molecular Layer Deposition through Iodo−Ene Coupling Chemistry (2017)

This work introduces photoactivated molecular layer deposition (pMLD) as a route to deposit organic nanoscale polymer films with molecular-level control. Surface-tethered acrylate polymers are obtained through a radical step-growth polymerization where a diene and a diiodo monomer, ethylene glycol dimethacrylate (EGM) and 1,3-diiodopropane (DIP), respectively, are sequentially dosed in the vapor-phase under pulsed UV irradiation. pMLD occurs with a constant growth rate of 3.7 Å/cycle, and both monomers display self-limiting saturation. Films deposited by pMLD exhibit excellent stability in organic solvents. Furthermore, annealing studies with in situ X-ray photoelectron spectroscopy (XPS) reveals thermal stability up to 350 °C in vacuum. The mechanism behind pMLD of EGM and DIP is proposed based on detailed characterization of the polymer films by XPS and Fourier transform infrared spectroscopy, growth modeling, and comparison with control studies of pMLD involving monofunctional precursors. The coupling chemistry of pMLD presented herein provides future possibilities to create apolar linkages in the formation of nanoscale organic films.
The Effect of Feeder Space Allowance on Weaned Pig Performance (1987)

A total of 826 weanling pigs was utilized in four studies to determine effects of feeder space on weaned pig performance and to discern if they were dependent on stocking density. Feeder space allowances varied from 2 to 12, 15.2-cm sections; stocking density varied from 5 to 12 pigs/pen (.11 to .22 m2 of floor space/pig). There were no feeder space × stocking density interactions (P>.10) for daily gain, daily feed or feed/gain. Feeder space allowance had no effect on feed/gain in any of the studies and was generally without effect on feed intake and daily gain, although in one study depressed feed intake and daily gain were observed in pens of pigs restricted to two 15.2-cm sections of feeder space. The effects of feeder space allowance on blood corticoid and antibody levels varied with stocking density. Feeder space allowance did not result in any differences of within-pen variation in body weight or daily gain.