gebhart/patrepeval huggingface dataset:
An Inexpensive Air-Stable Titanium-Based System for the Conversion of Esters to Primary Alcohols (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn Inexpensive Air-Stable Titanium-Based System for the Conversion of Esters to Primary AlcoholsMatthew T. Reding and Stephen L. BuchwaldCite this: J. Org. Chem. 1995, 60, 24, 7884–7890Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/jo00129a031https://doi.org/10.1021/jo00129a031research-articleACS PublicationsRequest reuse permissionsArticle Views1161Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reversible water uptake by a stable imine-based porous organic cage (2012)

A crystalline porous organic cage molecule, CC3, is shown to adsorb up to 20.1 wt% water reversibly. This was confirmed by both gravimetric sorption and by crystallographic analysis. Crystals of CC3 are stable in boiling water for at least 4 h. The surprising chemical and supramolecular stability of these imine-based molecular crystals suggests scope for practical applications in humid environments.
MULTI-SPECTRAL SENSOR FOR DETECTION OF NITROGEN STATUS IN COTTON (2005)

Based on the spectral characteristics of cotton canopies, a plant nitrogen sensor was designed and fabricated fordetection of nitrogen status in cotton plants. The sensor is an active optical multi-spectral sensing unit. It measures spectralreflectance from a cotton canopy in blue, green, red, and near infrared wavebands with a modulated illumination to the cottoncanopy. The sensor was tested in the laboratory and field, and promising results were obtained. This article describes thedesign, implementation, and testing of the sensor.
SCREENING FOR DEFICIENCIES IN THE CLASSICAL AND ALTERNATIVE PATHWAYS OF COMPLEMENT BY HEMOLYSIS IN GEL (1981)

Two assays based on hemolysis in gel were assessed for screening complement (C) component deficiencies. In one assay sensitized sheep erythrocyte (EA) were incorporated in agarose gel containing Ca2+ and Mg2+, in the other guinea pig erythrocytes (GpE) were used in the presence of Mg2+and EGTA. With few exceptions, fresh samples from healthy individuals produced homogeneous areas of complete hemolysis in both assays. Clearly aberrant patterns were observed in approximately 4% of healthy blood donors. Sera from patients having complete deficiencies of Clq, C2 or C4 produced clear lysis of GpE only, whereas in sera lacking C3 or C8 lysis was grossly impaired in both assays. Properdin deficient serum produced very slight lysis of GpE but normal lysis of EA. Reconstitution of these C-deficient sera gave normal lysis. Together, the two assays supplement immunochemical C3 and C4 determinations for screening out C disorders.
Gastrostomy tube placement by endoscopy versus radiologic methods in patients with ALS: A retrospective study of complications and outcome (2013)

Gastrostomy tube placement for malnutrition and weight loss stabilization occurs in many patients with ALS. We sought to compare the outcome and complications of gastrostomy tube placement by endoscopic (PEG) and multiple radiologic (RIG) methods in ALS patients. A retrospective analysis was conducted on all ALS patients evaluated at Northwestern University who received gastrostomy tubes between January 2009 and March 2012. One hundred and eight gastrostomy tube attempts were made on a total of 100 different patients. Failed gastrostomy tube placement occurred in 15.7% of PEGs and 1.9% of RIGs. Post-procedure aspiration was recognized after 10.5% PEG and 0 RIG attempts. Multivariate analysis revealed a linear increase in risk of post-procedure aspiration for every increase in ALSFRS swallow score. No statistically significant differences in failure or complications were observed when comparing two different methods of RIG (push-type vs. pull-type). Our findings support gastrostomy tube placement by radiographic methods in ALS patients. Gastrostomy tube placement by RIG was more often successful and less often associated with aspiration. Our findings add to the growing body of literature that argues for early gastrostomy tube placement in young patients with prominent bulbar involvement.
The brain‐specific gene for rat aldolase C possesses an unusual housekeeping‐type promoter (1989)

A DNA fragment encompassing the first exon and about 750 bp of the 5'-flanking sequence has been isolated and sequenced. The gene has multiple start sites of transcription which are dispersed over about 200 bp. The promoter lacks TATA and CAAT boxes and is very G + C-rich, with putative binding sites for the transcriptional factors Sp1 and AP2. Similar features are shared with two other brain-specific genes encoding thy-1 antigen and gamma-enolase. The existence of a conserved block of similarity upstream of the human and rat aldolase C genes suggests that this region could be involved in tissue-specific expression whose mechanism seem to be, at least in part, transcriptional.
Effects of Clostridium botulinum C2 toxin and cytochalasin D on in vitro invasiveness, motility and F-actin content of a murine T-lymphoma cell line. (1995)

In order to investigate the role of microfilaments in the crawling movements of lymphoid cells, we have analyzed the effects of botulinum C2 toxin and of cytochalasin D (cytoD) on the actin cytoskeleton and on the motility of a BW5147 T-lymphoma-derived cell line. Actin was ADP-ribosylated by C2 toxin in the living cells, and this resulted in a time and dose-dependent disappearance of F-actin, as assessed by staining with labeled phalloidin. CytoD did not affect the amount of polymerized actin, but rather changed its distribution from a diffuse peripheral network to focal accumulations on one side of the cell. Both treatments affected the motility of the lymphoma cells in two assay systems. Fourier analysis was used to quantify shape changes performed by the cells. C2 toxin as well as CytoD caused the cessation of pseudopodal protrusion. Invasion of the lymphoma cells through a monolayer of fibroblast-like cells was also inhibited by the treatments, in a dose-dependent way. C2 toxin significantly inhibited invasion at concentrations at which only part of the actin pool had been ADP-ribosylated. We conclude that partial depolymerization, as well as disorganization, of the microfilament network impairs the active cellular deformations that are involved in the crawling movements of the lymphoma cells. From previous work, there is evidence to state that the monolayer invasion assay to some extent mimics tissue infiltration by hematopoietic cells. The present study is the first to analyze the role of actin polymerization in a model system that is relevant for the migration of lymphoid cells in vivo.(ABSTRACT TRUNCATED AT 250 WORDS)
Android malware detection: An eigenspace analysis approach (2015)

The battle to mitigate Android malware has become more critical with the emergence of new strains incorporating increasingly sophisticated evasion techniques, in turn necessitating more advanced detection capabilities. Hence, in this paper we propose and evaluate a machine learning based approach based on eigenspace analysis for Android malware detection using features derived from static analysis characterization of Android applications. Empirical evaluation with a dataset of real malware and benign samples show that detection rate of over 96% with a very low false positive rate is achievable using the proposed method.
Abstract 4384: Targeting of 4-1BB by monoclonal antibody, PF-05082566, enhances T cell function and promotes antitumor activity (2012)

Abstract 4-1BB (CD137, TNFRSF9) is a costimulatory receptor expressed in an activation induced manner on several subsets of immune cells. Numerous studies of mouse and human T cells indicate that 4-1BB promotes enhanced cellular proliferation, survival, and cytokine production. 4-1BB agonist mAbs have demonstrated efficacy in prophylactic and therapeutic settings in both monotherapy and combination therapy tumor models and have established durable anti-tumor protective T cell memory responses. PF-05082566 is a fully human IgG2 which binds to the extracellular domain of human 4-1BB with high affinity and specificity. In preclinical studies this agonist antibody demonstrated its ability to activate NF-κB and induce downstream cytokine production, promote leukocyte proliferation, and inhibit tumor growth in a human PBMC xenograft tumor model. The mechanism of action and robust anti-tumor efficacy of PF-05082566 support its clinical development for the treatment of a broad spectrum of human malignancies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4384. doi:1538-7445.AM2012-4384
Earth-abundant electrocatalysts enhance competitiveness of electrocatalytic reduction of nitrate as point-of-use technology. (2020)

International audience
Imaging the cellular dynamics and signals that pattern embryos (2013)

Advances in cell biology, genomics and proteomics offer unprecedented knowledge of the constituents within cells and the means by which the cells can interact. Advanced imaging techniques provide a powerful means of integrating this growing data set into a mechanistic understanding of the cellular mechanisms that underlie embryogenesis and organogenesis, by studying the events in the intact system. These powerful techniques are challenged by major tradeoffs between spatial resolution, temporal resolution, and the limited photon budget. This combination of requirements is challenging, but necessary: intravital imaging can only generate accurate data on cell lineages and cell migration if it can capture the three dimensional image of the entire embryo or tissue before any of the cells can move half of the distance separating neighboring cells. We are attempting to advance these tradeoffs by constructing faster and more efficient microscopes that maintain subcellular resolution. Our new microscope combines the deep penetration of two‐photon microscopy and the speed of light sheet microscopy (often termed SPIM) to generate images with more than ten‐fold improved imaging speed and sensitivity. This two‐photon SPIM is far less subject to light scattering, permitting subcellular resolution to be maintained far better than conventional light sheet microscopes.
Hydrogen Isotope Separation Using a Metal–Organic Cage Built from Macrocycles (2022)

Porous materials that contain ultrafine pore apertures can separate hydrogen isotopes via kinetic quantum sieving (KQS). However, it is challenging to design materials with suitably narrow pores for KQS that also show good adsorption capacities and operate at practical temperatures. Here, we investigate a metal-organic cage (MOC) assembled from organic macrocycles and Zn<sup>II</sup> ions that exhibits narrow windows (<3.0 Å). Two polymorphs, referred to as 2α and 2β, were observed. Both polymorphs exhibit D<sub>2</sub> /H<sub>2</sub> selectivity in the temperature range 30-100 K. At higher temperature (77 K), the D<sub>2</sub> adsorption capacity of 2β increases to about 2.7 times that of 2α, along with a reasonable D<sub>2</sub> /H<sub>2</sub> selectivity. Gas sorption analysis and thermal desorption spectroscopy suggest a gate-opening effect of the MOCs pore aperture. This promotes KQS at temperatures above liquid nitrogen temperature, indicating that MOCs hold promise for hydrogen isotope separation in real industrial environments.
Electroacoustic Modeling of Magnetostrictive Shells and Rings. Part 2. EIGSHIP Predicted Performance; Experimental Measurements; and Computer Listing of EIGSHIP. (1976)

The mathematical model of the electroacoustic performance of a force-driven free-flooding magnetostrictive cylinder shell used as an underwater sound transducer, originally developed in another report, has been coded into a computer program called EIGSHIP. This program is designed to predict electrical and mechanical impedances of the loaded shell, transmitting responses, electroacoustic efficiency, surface velocities, far-field beam patterns, and other relevant performance parameters. An experimental check on the prediction capabilities of EIGSHIP was undertaken on three specially constructed magnetostrictive shells which were tested under water load conditions in an indoor test facility. A full discussion of the comparison of predicted and measured performance is presented. The coded listing of EIGSHIP and instructions on its input requirements and output format are furnished in detail. Samples of typical computer runs are displayed and commented on.
On the accuracy and simplifications of battery models using in situ measurements of Lithium concentration in operational cells (2012)

In an effort to evaluate the accuracy of various battery models we use neutron imaging which is a nondestructive in situ measurement technique that has been successfully used to track the migration of lithium between the anode and cathode electrode layers during battery operation. In this work we extend the previous results, acquired during steady state conditions, by studying the transient behavior of the lithium concentration distribution across the electrode during charging and discharging. The thermal neutron beam-line at the National Institute for Standards and Technology (NIST) Center for Neutron Research was used to measure the Lithium concentration in an operating Lithium Iron Phosphate (LFP) pouch cell battery with typical commercial electrodes. A stroboscopic imaging technique was developed to generate images with longer effective exposure time, increasing the signal to noise ratio and enabling measurement of changes in lithium concentration during high power transients. The measurement of the solid phase lithium concentration distribution across the electrode for high rate (7.5C / 3C) short duration (20-40s) pulses are compared with the simulated distributions from a commercial battery simulation software package using the same experimental conditions.
Partly MHC Matched Allogeneic Tumor Specific T Cells Mediate Tumor Regression without Inducing GVHD in Immunosuppressed Host. (2006)

Abstract Adoptive cell transfer (ACT) immunotherapy following lymphodepleting conditioning is a promising strategy for the treatment of metastatic solid tumors, however the difficulties in generating autologous tumor specific lymphocytes for every patient has significantly limited its applications. Allogeneic partly matched tumor specific T cells could be used for patients in whom autologous cells are not available, however their rapid rejection by the host restricts this approach. When CD8+ pmel-1 T cells from B6-BALB-C F1 (b/d) were transferred into B16 tumor-bearing B6 mice (b/b) or into a different F1 (b/k), these tumor-specific T cells were rapidly rejected, and had no impact on the tumor regression. Here we show that following myeloablative conditioning, the adoptive transfer of allogeneic, major histocompatibility mismatched tumor-specific T lymphocytes resulted in the regression of large vascularized tumors. The ability of adoptively transferred allogeneic T cells to mediate tumor regression was directly proportional to the dose of irradiation given prior T cell transfer which also correlated with the in vivo survival of the transferred cells. At the highest irradiation dose used (i.e. 11 Gy) allogeneic T cells could survive for as long as 4 weeks and their efficacy was comparable to syngeneic tumor-reactive T cells. In addition we found that the risk of inducing a graft versus host (GVH) reaction was minor when the specificity of transferred TCR is confined. In fact co-transfer of transgenic cells and small amounts of open repertoire T cells (2*10e4) able to react with the host did not result in any measurable toxicity whereas co transfer of greater quantities (2*10e5 or more) could cause fatal GVHD effect. Interestingly GVH reaction was associated with an improved tumor treatment, though this effect was transient as most of the animals succumbed to GVHD. Here we demonstrate that allogeneic T cells might represent an important tool in cancer immunotherapy allowing treatment of patients for whom it is not possible to obtain autologous cells. Furthermore the possible synergy between tumor specific allogeneic T cells and GVH effect could be exploited in bone marrow transplant protocols.
Inferring Visual Biases in UAV Videos from Eye Movements (2020)

Unmanned Aerial Vehicle (UAV) imagery is gaining a lot of momentum lately. Indeed, gathered information from a bird-point-of-view is particularly relevant for numerous applications, from agriculture to surveillance services. We herewith study visual saliency to verify whether there are tangible differences between this imagery and more conventional contents. We first describe typical and UAV contents based on their human saliency maps in a high-dimensional space, encompassing saliency map statistics, distribution characteristics, and other specifically designed features. Thanks to a large amount of eye tracking data collected on UAV, we stress the differences between typical and UAV videos, but more importantly within UAV sequences. We then designed a process to extract new visual attention biases in the UAV imagery, leading to the definition of a new dictionary of visual biases. We then conduct a benchmark on two different datasets, whose results confirm that the 20 defined biases are relevant as a low-complexity saliency prediction system.
BR140, a Novel Zinc-Finger Protein with Homology to the TAF250 Subunit of TFIID (1994)

The Br140 protein was initially identified due to its co-purification with an integrin. We have cloned and sequenced the cDNA corresponding to the Br140 protein. Analysis of the amino acid sequence indicates that Br140 has features characteristic of gene regulatory proteins, including zinc fingers. Furthermore, Br140 has a homology to a family of transcriptional co-activators, one of which is a characterized component of the general transcriptional machinery. Immunologic studies indicate that Br140 has a broad tissue distribution and is abundant in testes and spermatogonia. Br140 is primarily a nuclear protein. These results suggest that Br140 may be a part of the general transcriptional machinery.
An Investigation of Radiation Heat Transfer in a Light-Duty Diesel Engine (2015)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;In the last two decades engine research has been mainly focused on reducing pollutant emissions. This fact together with growing awareness about the impacts of climate change are leading to an increase in the importance of thermal efficiency over other criteria in the design of internal combustion engines (ICE). In this framework, the heat transfer to the combustion chamber walls can be considered as one of the main sources of indicated efficiency diminution. In particular, in modern direct-injection diesel engines, the radiation emission from soot particles can constitute a significant component of the efficiency losses. Thus, the main of objective of the current research was to evaluate the amount of energy lost to soot radiation relative to the input fuel chemical energy during the combustion event under several representative engine loads and speeds. Moreover, the current research characterized the impact of different engine operating conditions on radiation heat transfer. For this purpose, a combination of theoretical and experimental tools were used. In particular, soot radiation was quantified with a sensor that uses two-color thermometry along with its corresponding simplified radiation model. Experiments were conducted using a 4-cylinder direct-injection light-duty diesel engine fully instrumented with thermocouples. The goal was to calculate the energy balance of the input fuel chemical energy. Results provide a characterization of radiation heat transfer for different engine loads and speeds as well as radiation trends for different engine operating conditions.&lt;/div&gt;&lt;/div&gt;
Direct Synthesis of Six-Monolayer (1.9 nm) Thick Zinc-Blende CdSe Nanoplatelets Emitting at 585 nm (2018)

Here, quasi-two-dimensional semiconductor nanoplatelets (NPLs) have garnered widespread interest because of their uniquely narrow emission spectra and favorable characteristics for optical gain and lasing.(1–5) Strongly quantum confined along thickness, NPLs exhibit the electronic structure of quantum wells determined by their thickness, which can be controlled with atomic precision.(6–10) Among all semiconductor NPLs, CdSe NPLs are probably the most studied. So far, four kinds of CdSe NPLs, emitting at around 396 nm, 463 nm, 513m, and 553 nm, have been intensely investigated for almost a decade.(11–18) Despite some early confusions in identifying actual thicknesses of those NPLs, they have been successfully assigned to be 2-monolayer (2 ML) to 5-monolayer (5 ML) thickness by high-resolution TEM.(19) Here, nML thickness corresponds to n chalcogen layers sandwiched between n + 1 metal layers. Another kind of NPLs with 6MLs of CdSe, once briefly mentioned in 2013,(20) however, was not explored, likely because its synthesis proved hard to reproduce. The 6 ML CdSe NPLs can be prepared by the colloidal atomic layer deposition (c-ALD) method,(21) but there have been no reports on direct synthesis of 6 ML CdSe NPLs, and their direct synthesis has been in doubt as being difficult by traditional approaches.(22,23)
Immunohistochemical detection of FGF-23 protein in tumors that cause oncogenic osteomalacia (2003)

We conclude that OOM tumors express FGF-23 protein and that the immunohistochemical detection of FGF-23 in OOM tumors is feasible and may help in establishing the diagnosis of tumor-induced hypophosphatemia through analysis of biopsies or surgical specimens.
Uniaxial anisotropy and its manipulation in amorphous Co68Fe24Zr8 thin films (invited) (2014)

We have proven that the growth of Co68Fe24Zr8 layers under external field yields a uniaxial anisotropy, defined by the direction of the field. No magnetic coupling is present between Co68Fe24Zr8 layers when separated by a 3 nm of Al70Zr30. The anisotropy axis can therefore be manipulated at will and the direction can be tailored, layer by layer in multilayers, by the choice of the direction of the applied field during growth. The g-factor (2.13) and the anisotropy constant, obtained from ferromagnetic resonance, support the existence of short-range order. The relation between the temperature dependences of magnetic anisotropy and magnetization are partially captured by Callen-Callen power law.