gebhart/patrepeval huggingface dataset:
C/EBP Bypasses Granulocyte Colony-Stimulating Factor Signals to Rapidly Induce PU.1 Gene Expression, Stimulate Granulocytic Differentiation, and Limit Proliferation in 32D cl3 Myeloblasts (1999)

Within hematopoiesis, C/EBP is expressed only in myeloid cells, and PU.1 is expressed mainly in myeloid and B-lymphoid cells. C/EBP-deficient mice lack the neutrophil lineage and retain monocytes, whereas PU.1-deficient mice lack monocytes and have severely reduced neutrophils. We expressed a C/EBP-estrogen receptor ligand-binding domain fusion protein, C/EBPWT-ER, in 32D cl3 myeloblasts. 32D cl3 cells proliferate in interleukin-3 (IL-3) and differentiate to neutrophils in granulocyte colony-stimulating factor (G-CSF). In the presence of estradiol, C/EBPWT-ER induced morphologic differentiation and the expression of the myeloperoxidase, lactoferrin, and G-CSF receptor mRNAs. C/EBPWT-ER also induced a G1/S cell cycle block, with induction of p27 and Rb hypophosphorylation. bcr-ablp210 prevented 32D cl3 cell differentiation. Activation of C/EBP-ER in 32D-bcr-ablp210 or Ba/F3 B-lymphoid cells induced cell cycle arrest independent of terminal differentiation. C/EBPWT-ER induced endogenous PU.1 mRNA within 8 hours in both 32D cl3 and Ba/F3 cells, even in the presence of cycloheximide, indicating that C/EBP directly activates the PU.1 gene. However, activation of a PU.1-ER fusion protein in 32D cl3 cells induced myeloperoxidase (MPO) RNA but not terminal differentiation. Thus, C/EBP acts downstream of G-CSF and upstream of PU.1, p27, and potentially other factors to induce myeloblasts to undergo granulocytic differentiation and cell cycle arrest.
Deposition of in situ boron-doped polycrystalline silicon films at reduced pressures (1994)

We report on the deposition of in situ boron-doped polycrystalline Si films on the SiO2 surface with reduced growth pressures at 550 °C. The deposition rate of these films decreased as the doping level was greater than 1019 cm−3. Such a result is in sharp contrast to what has been observed previously for similar films grown with conventional low pressure chemical vapor deposition techniques. It was also found that the incubation time prior to the deposition of these films diminished as the doping level was increased to 3×1020 cm−3 or higher. It is attributed to the preferential adsorption of boron atoms on the SiO2 surface at the initial stage of growth, which facilitates the nucleation of Si.
Intestinal peroxisomal fatty acid β-oxidation regulates neural serotonin signaling through a feedback mechanism (2019)

The ability to coordinate behavioral responses with metabolic status is fundamental to the maintenance of energy homeostasis. In numerous species including Caenorhabditis elegans and mammals, neural serotonin signaling regulates a range of food-related behaviors. However, the mechanisms that integrate metabolic information with serotonergic circuits are poorly characterized. Here, we identify metabolic, molecular, and cellular components of a circuit that links peripheral metabolic state to serotonin-regulated behaviors in C. elegans. We find that blocking the entry of fatty acyl coenzyme As (CoAs) into peroxisomal β-oxidation in the intestine blunts the effects of neural serotonin signaling on feeding and egg-laying behaviors. Comparative genomics and metabolomics revealed that interfering with intestinal peroxisomal β-oxidation results in a modest global transcriptional change but significant changes to the metabolome, including a large number of changes in ascaroside and phospholipid species, some of which affect feeding behavior. We also identify body cavity neurons and an ether-a-go-go (EAG)-related potassium channel that functions in these neurons as key cellular components of the circuitry linking peripheral metabolic signals to regulation of neural serotonin signaling. These data raise the possibility that the effects of serotonin on satiety may have their origins in feedback, homeostatic metabolic responses from the periphery.
Subgap Density of States of Amorphous Indium Gallium Zinc Oxide (a-IGZO) Thin Film Transistors (2022)

In amorphous oxide semiconductors such as indium gallium zinc oxide (a-IGZO), subgap states often play an important role in determing thin-film transistor (TFT) operation metrics such as turn-on voltage, mobility, hysteresis, and bias-stress stability. Using a-IGZO TFTs, we are able to resolve (over 6 orders of magnitude) the photoconduction response of a-IGZO spanning the subgap region (from 0.3-3.5 eV) in order to elucidate the subgap density of states (DoS). 1 In this presentation, we will focus on two significant findings related to the nature of a-IGZO subgap states. First, hydrogen is found to act as a negative-U donor in a-IGZO, contributing an electron to the conduction band before bonding with valence band oxygen 2p states, thereby forming an [O O 2- H + ] - defect complex whose Gaussian-like DoS are positioned 0.4 eV above the valence band mobility edge. 2 Second, bottom-gate, back-channel etched a-IGZO TFTs are found to have a Gaussian-like zinc vacancy-related subgap state centered roughly 2.3 eV below the conduction band mobility edge, a feature that is not present in top-gate a-IGZO TFTs. K. Vogt et al. Phys. Rev. Research 2 (Sep. 2020). 10.1103/PhysRevResearch.2.033358 G. Mattson et al. arXiv:2111.08588 Figure 1
pH‐Switchable Helicity of DNA‐Templated Assemblies (2009)

Coming together: Oligothymine is used as a template to self-assemble complementary nonchiral naphthalene guests. Depending on the protonated state of the guest, left- or right-handed DNA-templated self-assemblies are formed (see picture). The templated assembly processes were studied in detail with temperature-dependent circular dichroism and UV/Vis spectroscopy. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Carbon Footprint Analysis of Gasoline and Diesel from Forest Residues and Corn Stover using Integrated Hydropyrolysis and Hydroconversion (2015)

With an increasing focus on renewable fuels, it is vital to understand the environmental impacts from various alternative transportation fuel products and processes under development. This study analyzes greenhouse gas (GHG) emissions of renewable gasoline and diesel produced by the integrated hydropyrolysis and hydroconversion (IH2) process at an existing petroleum refinery in Memphis, TN, USA. In this study, we considered forest residues from the southeastern US and corn stover from the Midwest as the two feedstocks. H2 required for the process is either imported from a steam methane reformer using natural gas or produced from C1–C3 gas coproducts of the IH2 process. Life cycle GHG emission savings of 67–86% were calculated for IH2 gasoline and diesel compared to their fossil counterparts, depending on feedstock, transport and H2 sources. Monte Carlo simulations were conducted to assess the impact of input parameter uncertainty on the final GHG emission results. The impact of applying biochar coproduct as a soil amendment and soil carbon change due to residue harvest were also studied.
Robust Super-Resolution for Mixed-Resolution Multiview Image Plus Depth Data (2015)

Increasing spatial resolution and thus improving the image quality is a key issue in the mixed-resolution multiview image and video processing domain. Given adjacent camera perspectives with various spatial resolutions and their corresponding depth information, the high-frequency part of a high-resolution view can be used for increasing the image quality of a neighboring low-resolution camera perspective. However, a reasonable projection of high-frequency information onto the image plane of a neighboring low-resolution view typically requires pixel-wise error-free depth data for the high-resolution reference image. Starting from this, a novel image super-resolution approach is proposed that is robust against both inaccurate depth acquisition and nonperfect calibration of spatially low-resolution depth sensors. The algorithm is based on displacement-compensated high-frequency synthesis and aims at correcting the projection errors introduced by inaccurate depth information. The proposed approach is further effectively extended by a signal extrapolation technique. For a wide range of proper scenarios, the proposed framework achieves substantial objective and visual gains compared with the considered reference approaches. The improvement of quality is shown for both simulated and self-recorded experimental data.
A NEWLY IDENTIFIED ORAL MYCOPLASMA (M. ORALE) AND ITS RELATIONSHIP TO OTHER HUMAN MYCOPLASMAS (1964)

Journal Article A NEWLY IDENTIFIED ORAL MYCOPLASMA (M. ORALE) AND ITS RELATIONSHIP TO OTHER HUMAN MYCOPLASMAS Get access D. TAYLOR-ROBINSON, D. TAYLOR-ROBINSON Search for other works by this author on: Oxford Academic PubMed Google Scholar J. CANCHOLA, J. CANCHOLA 2Children's Hospital, Research FoundationWashington, D. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar H. FOX, H. FOX Search for other works by this author on: Oxford Academic PubMed Google Scholar R. M. CHANOCK R. M. CHANOCK Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 80, Issue 1, July 1964, Pages 135–148, https://doi.org/10.1093/oxfordjournals.aje.a120454 Published: 01 July 1964 Article history Received: 13 March 1964 Published: 01 July 1964
Quantum Extremal Learning (2022)

We propose a quantum algorithm for `extremal learning', which is the process of finding the input to a hidden function that extremizes the function output, without having direct access to the hidden function, given only partial input-output (training) data. The algorithm, called quantum extremal learning (QEL), consists of a parametric quantum circuit that is variationally trained to model data input-output relationships and where a trainable quantum feature map, that encodes the input data, is analytically differentiated in order to find the coordinate that extremizes the model. This enables the combination of established quantum machine learning modelling with established quantum optimization, on a single circuit/quantum computer. We have tested our algorithm on a range of classical datasets based on either discrete or continuous input variables, both of which are compatible with the algorithm. In case of discrete variables, we test our algorithm on synthetic problems formulated based on Max-Cut problem generators and also considering higher order correlations in the input-output relationships. In case of the continuous variables, we test our algorithm on synthetic datasets in 1D and simple ordinary differential functions. We find that the algorithm is able to successfully find the extremal value of such problems, even when the training dataset is sparse or a small fraction of the input configuration space. We additionally show how the algorithm can be used for much more general cases of higher dimensionality, complex differential equations, and with full flexibility in the choice of both modeling and optimization ansatz. We envision that due to its general framework and simple construction, the QEL algorithm will be able to solve a wide variety of applications in different fields, opening up areas of further research.
Activated Porous Carbon Spheres with Customized Mesopores through Assembly of Diblock Copolymers for Electrochemical Capacitor (2017)

A series of porous carbon spheres with precisely adjustable mesopores (4-16 nm), high specific surface area (SSA, ∼2000 m<sup>2</sup> g<sup>-1</sup>), and submicrometer particle size (∼300 nm) was synthesized through a facile coassembly of diblock polymer micelles with a nontoxic dopamine source and a common postactivation process. The mesopore size can be controlled by the diblock polymer, polystyrene-block-poly(ethylene oxide) (PS-b-PEO) templates, and has an almost linear dependence on the square root of the degree of polymerization of the PS blocks. These advantageous structural properties make the product a promising electrode material for electrochemical capacitors. The electrochemical capacitive performance was studied carefully by using symmetrical cells in a typical organic electrolyte of 1 M tetraethylammonium tetrafluoroborate/acetonitrile (TEA BF<sub>4</sub>/AN) or in an ionic liquid electrolyte of 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIMBF<sub>4</sub>), displaying a high specific capacitance of 111 and 170 F g<sup>-1</sup> at 1 A g<sup>-1</sup>, respectively. The impacts of pore size distribution on the capacitance performance were thoroughly investigated. It was revealed that large mesopores and a relatively low ratio of micropores are ideal for realizing high SSA-normalized capacitance. These results provide us with a simple and reliable way to screen future porous carbon materials for electrochemical capacitors and encourage researchers to design porous carbon with high specific surface area, large mesopores, and a moderate proportion of micropores.
Backscatter monitoring of high intensity focused ultrasound therapy using a parametric treatment model (2010)

Accurate monitoring of high intensity focused ultrasound (HIFU) surgery is critical to ensuring proper treatment. Pulse‐echo diagnostic ultrasound (DU) is a recognized modality for identifying temperature differentials using speckle tracking between two DU radio frequency (RF) frames [2], [4]. This observation has motivated non‐parametric temperature estimation, which associates temperature changes directly with the displacement estimates. We present an estimation paradigm termed displacement mode analysis (DMA), which uses physical modeling to associate particular patterns of observed displacement, called displacement modes, with corresponding modes of variation in the administered therapy. This correspondence allows DMA to estimate therapy directly using a linear combination of displacement modes, imbuing these displacement estimates into the reference using interpolation, and by aligning with the treatment frame, providing a therapy estimate with the heating modes. Since DMA is maximum likelihood estimation (MLE), the accuracy of its estimates can be assessed a priori, providing error bounds for estimates of applied heating, temperature, and thermal dose. Predicted performance is verified using both simulation and experiment for a point exposure of 4.2 Watts of electrical power in alginate, a tissue mimicking phantom.
Photoacoustic cell on silicon for mid-infrared QCL-based spectroscopic analysis (2019)

Photoacoustic (PA) spectroscopy is among the most sensitive techniques used to monitor chemical emission or detect gas traces. In the mid-infrared, where most of gases of interest have their strongest absorption lines, this technique takes advantage of the high optical power and room temperature operation of quantum cascade lasers (QCL). We have recently demonstrated that centimeter-size PA cells can compete, with bulky commercial systems for gas sensing without any compromises on performances. We demonstrate a new step towards cost reduction, extreme integration, and mass deployment of such PA sensors with a miniaturized silicon PA-cell fabricated on standard CMOS tools. The design, fabrication and characterizations of this new sub-centimeter PA cell built on a silicon platform are presented. First, the component has been designed using a detailed physical model, accounting for viscous and thermal losses, and metamodel-based optimization techniques. Second, it has been fabricated on our 200 mm CMOS pilot line. Several wafers have been released and diced. Single chips have then been assembled with commercial capacitive microphones and finally characterized on our reference gas bench. The photoacoustic simulations and the acoustics experiments are in a good agreement. The tiny PA cell exhibits a sensitivity down to the ppm level for CO<sub>2</sub> at 2300 cm<sup>-1</sup>, as well as for CH<sub>4</sub> at 3057 cm<sup>-1</sup> even in a gas flow. Taking advantage of the integration of QCLs on Si and photonic circuitry, the silicon PA cell concept is currently being extended towards a fully integrated multigas detector.
High Density Magneto-Optical Recording with a Second-Harmonic Generation Green Laser (1993)

Tripled areal density optical recording was realized with the combination of a high power laser-diode pumped intracavity frequency-doubled Nd:YAG laser (SHG green laser), a low noise GdFeCo/TbFeCo double-layered magneto-optical (MO) disk, and high sensitivity photodetectors optimized for the wavelength of the light source. A high carrier-to-noise ( C / N ) ratio of more than 48 dB and a bit error rate of less than 3×10 -6 by (2, 7) run-length-limited (RLL) mark position recording was obtained at a mark length of 0.45 µm (0.6 µm/bit) for a disk with a 0.9 µm track pitch.
Study of the environment effect by M-Sequence UWB radar on detection of a walking human (2016)

This paper presents an experimental comparison study of human movement and presence detection in different environments using ultra-wide-band (UWB) M-Sequence radar. The benchmarking measurements are made in an anechoic chamber and repeated in an open office environment. The wave forms of the background noise and scattered amplitudes of a human body are measured and compared. The result is analyzed and discussed. A set of detection algorithms and filters which are developed to track the human movement and presence is presented and the tracking results in these two environments are compared to each other.
Development of Ambient Nanogibbsite Synthesis and Incorporation of the Method To Embed Ultrafine Nano-Al(OH)3 into Channels and Partial Alumination of MCM-41 (2016)

An ultrafine aluminum hydroxide nanoparticle suspension was prepared via the controlled titration of [Al(H2O)6]3+ with l-arginine to pH 4.6. The prepared material, predominantly 10–30 nm in diameter, was purified by GPC and subsequently identified as the gibbsite (or hydrargillite) polymorph via FTIR, powder XRD, and elemental analysis. The material’s chemical environment and morphology were probed using 27Al/1H NMR, FTIR, ICP-OES, TEM-EDS, XPS, XRD, and N2 adsorption experiments. Furthermore, by incorporating the newly developed synthetic route, Al(OH)3 was partially loaded inside the mesopores (2.7 nm) of MCM-41. EDS and NMR analysis indicated that both tetrahedral and octahedral Al (Oh/Td = 1.4) are incorporated at 11% w/w total Al and that the Si/Al ratio is 2.9, indicating that part of the Al is embedded in the Si framework. In addition, differences in elemental composition between surface XPS and bulk EDS analysis provided insight into the distribution of Al within the material. A higher Si/Al ratio was observed on the external surface (3.6) of MCM-41 compared to that of the internal (2.9) cavities. Estimated O/Al ratios suggest predominantly Al(O)3 and Al(O)4 motifs present near the core and external surface, respectively. This novel methodology produces Al-MCM-41 with relatively high Al content while preserving the ordered SiO2 framework and can be used in lateral applications where incorporating hydrated or anhydrous Al2O3 is desired.
A phase 3, randomized, double-blind study of luspatercept (ACE-536) in patients (pts) with Revised International Prognostic Scoring System (IPSS-R) very low- to intermediate-risk myelodysplastic syndromes (MDS) with ring sideroblasts (RS) who require red blood cell (RBC) transfusions: The MEDALIST trial. (2016)

TPS7076 Background: Management of anemia is a common therapeutic challenge in pts with MDS. Approx. 30% of MDS pts have ≥ 15% RS in the bone marrow (BM) accompanied by ineffective erythropoiesis. Luspatercept (ACE-536), a novel activin type IIB receptor fusion protein, regulates late-stage erythroid differentiation. Preliminary phase 2 data suggest luspatercept improves erythropoiesis in lower-risk MDS pts with promising activity in pts with RS, with achievement of hematologic improvement and reduced need for transfusion in 55% and 39%, respectively, at doses ≥ 0.75 mg/kg. MEDALIST is a phase 3, randomized, double-blind, placebo (PBO)-controlled, multicenter study to determine the efficacy and safety of luspatercept for treatment of anemia in pts with lower-risk MDS ( < 5% BM blasts) and RS ( ≥ 15%) requiring RBC transfusion (average ≥ 2 units packed RBCs/8 weeks [wks]) who are refractory/intolerant or have a low chance of response to erythropoiesis-stimulating agents (serum erythropoietin > 200 IU/L). Methods: Pts aged ≥ 18 years are randomized 2:1 to luspatercept 1.0 mg/kg starting dose or PBO subcutaneously every 3 wks for ≥ 24 wks; no crossover between treatment arms is allowed. Stratification is by baseline RBC transfusion burden ( ≥ 6 RBC units/8 wks vs < 6 RBC units/8 wks) and baseline IPSS-R risk category (Very Low/Low vs Intermediate). Primary endpoint is rate of RBC transfusion independence (RBC-TI) ≥ 8 wks during the first 24 wks of treatment. Secondary endpoints include RBC-TI ≥ 12 wks, safety, quality of life, duration of RBC-TI, AML progression, overall survival, and mean hemoglobin increase ≥ 1.0 g/dL. Pts with evidence of clinical benefit and no progression to IPSS-R High/Very High-risk MDS or AML at wk 25 enter a double-blind extension phase until loss of clinical benefit, unacceptable toxicity, disease progression, or other discontinuation criteria. Post-treatment long-term follow-up is ≥ 2 years. The study is open to enrollment as of Dec 2015; target enrollment is 210 pts. Clinical trial information: NCT02631070.
Seasonal Changes in Serum Thyroid Hormone Binding Proteins in the Woodchuck (Marmota monax)* (1986)

To evaluate the role of serum T4- and T3-binding proteins in the elevation of serum T4 and T3 concentrations in the woodchuck in the fall and winter, blood was collected from woodchucks during the four seasons of the year (seasonal study) and from 2-week fasted woodchucks in the summer (fasting study) and the serum concentrations of total T4 and T3 were measured. The distribution of [125I]4 and [125I]T3 tracers among the serum binding proteins and the serum T4-binding globulin (TBG) binding capacity for T4 was determined by polyacrylamide gel electrophoresis. Plasma concentrations of both T4 and T3 were highest in the winter. The major T4-binding protein in the woodchuck is TBG. There was an increase in both [125I]T4 and [125I]T3 tracer binding to serum TBG in fall and winter, and TBG binding capacity for T4 was 2-fold higher in winter than in summer. There were increases in TBG binding and in the TBG T4 binding capacity in the 2-week starved animals. The increased binding of T4 and T3 by TBG in the fall and winter may be partially responsible for the increased serum concentrations of T4 and T3 in the fall and winter in the woodchuck, a time when secretion of T4 and T3 by the thyroid gland is very low. This may be facilitated by the low or absent food consumption at these times of the year.
A New Route to Porphyrins Substituted with Long Alkoxy Groups, Attempts to Prepare the Discotic Liquid Crystals (1996)

Abstract Pyrroles substituted with long alkoxy groups are prepared by the reaction of iminodiacetic acid dimethyl ester and dimethyl oxalate and the subsequent alkylation. These pyrroles are good precursor molecules for the corresponding porphyrins, which are expected to form an ordered columnar mesophase and are able to co-ordinate to various metals.