gebhart/patrepeval huggingface dataset:
eQTL analysis from microarray data of fibre expressed genes in an inter-specific Gossypium hirsutum x G. barbadense RIL population. (2010)

Microarrays provide a wealth of genome-wide gene expression data to characterise the biological variability between different plant genotypes, however it remains difficult to link such genomic results to a functional interpretation of how specific gene action determines a particular plant phenotype. Phenotypes themselves can be associated with specific regions of the genome by traditional QTL mapping, but most QTLs are very large physical regions that do not often allow the identification of specific underlying genes, particularly in species like cotton lacking a full genome sequence. Combining QTL and microarray analyses is a novel way to narrow down on subsets of candidate genes whose level of expression can be statistically correlated to regions of the genome, so-called eQTLs, and further correlated to specific phenotypes. In this study we used a RIL population of 145 lines from an inter-specific cross between a G. barbadense Sea-Island accession (VH8) with very high fibre quality and a G. hirsutum cultivar of moderate fibre quality (Guazuncho II). The RIL population had been phenotyped for fibre quality traits at multiple sites and in most cases over multiple years and had also been genotyped. The consensus genetic map for the population contained over 600 SSR and AFLP markers and was used as the framework for both phenotypic QTL and eQTL mapping. Microarray analyses (approx. 24,000 genes per array) were carried out on 10 dpa fibre cDNA on 102 of the RILs and the individual gene expression values for each transcript treated as a quantitative trait and mapped to the genome. The distribution of eQTLs was not uniform across the chromosomes, with chromosomes 5 and 12 having more eQTLs than any others. A number eQTL hotspots were identified that may represent the locations of master regulators of fibre expressed genes. A selection of genes co-located with the phenotypic QTLs for fibre traits were also identified and validated by quantitative PCR. Some, but not all eQTLs identified from the microarray data were confirmed by Q-PCR. Large correlations tables of the expression of all the genes on the arrays and specific fibre traits like length, strength and fineness were developed and are also being used to identify potential candidate genes that may be causal in conferring the commercially useful properties of cotton fibres.
Generation of functional liver tissue by establishing hepatobiliary connections ex vivo (2020)

<title>Abstract</title> In the liver, the bile canaliculi of hepatocytes are connected to intrahepatic bile ducts lined with cholangiocytes, which remove cytotoxic bile from the liver tissue. We have developed a hepatobiliary organoid using mouse hepatocyte progenitors and cholangiocytes. Hepatocyte metabolites were secreted into the bile canaliculi, and then transported into the biliary structure. Hepatocytes in the organoid acquired and maintained metabolic functions including albumin secretion and cytochrome P450 activities, over the long term. In this study, we established functional liver tissue incorporating a bile drainage system <italic>ex vivo</italic>. This hepatobiliary organoid enabled us to reproduce the transport of hepatocyte metabolites in liver tissue, and to investigate the way in which the two types of epithelial cells establish functional connections.
DreamStream: Immersive and Interactive Spectating in VR (2022)

Today spectating and streaming virtual reality (VR) activities typically involves spectators viewing a 2D stream of the VR user’s view. Streaming 2D videos of the game play is popular and well-supported by platforms such as Twitch. However, the generic streaming of full 3D representations is less explored. Thus, while the VR player’s experience may be fully immersive, spectators are limited to 2D videos. This asymmetry lessens the overall experience for spectators, who themselves may be eager to spectate in VR. DreamStream puts viewers in the virtual environment of the VR application, allowing them to look “over the shoulder” of the VR player. Spectators can view streamed VR content immersively in 3D, independently explore the VR scene beyond what the VR player sees and ultimately cohabit the virtual environment alongside the VR player. For the VR player, DreamStream provides a spatial awareness of all their spectators. DreamStream retrofits and works with existing VR applications. We discuss the design and implementation of DreamStream, and carry out three qualitative informal evaluations. These evaluations shed light on the strengths and weakness of using DreamStream for the purpose of interactive spectating. Our participants found that DreamStream’s VR viewer interface offered increased immersion, and made it easier to communicate and interact with the VR player.
Stochastic MPC with Dual Control for Autonomous Driving with Multi-Modal Interaction-Aware Predictions (2022)

We propose a Stochastic MPC (SMPC) approach for autonomous driving which incorporates multi-modal, interaction-aware predictions of surrounding vehicles. For each mode, vehicle motion predictions are obtained by a control model described using a basis of fixed features with unknown weights. The proposed SMPC formulation finds optimal controls which serves two purposes: 1) reducing conservatism of the SMPC by optimizing over parameterized control laws and 2) prediction and estimation of feature weights used in interaction-aware modeling using Kalman filtering. The proposed approach is demonstrated on a longitudinal control example, with uncertainties in predictions of the autonomous and surrounding vehicles.
Quantitative determination of interfacial copolymers from co-extruded films A Physicochemical and engineering aspects (2017)

A new method of quantitative determination of interfacial copolymers was investigated. Because of the small amount of these copolymers, the measurement is hard and only one technique is available: photoelectron X spectroscopy (XPS). However, as the method is an atomic response, it cannot be executed to any materials: copolymers have to contain different atom from the bulk. In this paper, we show that titration of interfacial copolymers polyamide 6-co-polypropylene-grafted anhydrid maleic (PA6-co-PP-g-AM) can also be done by Fourier Transform Infrared (FTIR). Concerning the quantitative determination of ethylene vinyl alcohol-polypropylene-grafted anhydrid maleic interfacial copolymers (EVOH-co-PP-g-AM), nothing is reported in literature. We show here, that FTIR can measure surface density of those copolymers provided that alcohol functions of EVOH are modified to ester groups.
ChemInform Abstract: Catalytic Activity of Titanium Silicates Synthesized in the Presence of Alkali Metal and Alkaline Earth Ions. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effects of Caloric Restriction and Growth Hormone Resistance on Insulin-Related Intermediates in the Skeletal Muscle (2007)

Growth hormone receptor-deficient (GHRKO) mice are long-lived and have reduced insulin-like growth factor (IGF)-1 and insulin levels and enhanced insulin sensitivity thus resembling the phenotype of animals subjected to calorie restriction (CR). In contrast to its effects in normal mice, CR does not improve insulin sensitivity or increase longevity in GHRKO males. In an attempt to identify mechanisms underlying this differential response to CR, effects of CR on the expression of insulin-related genes were compared in GHRKO and normal mice. In addition to changes detected in both genotypes, and responses unique to GHRKO mice, the levels of Akt2 and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC1alpha) were increased and levels of phosphorylated c-Jun N-terminal kinase (JNK)1 were reduced in response to CR only in normal mice. These changes may be related to mechanisms of improving insulin sensitivity and life expectancy.
Investigation of the process of mixing reagents in the laser chamber of active medium generators of continuous-wave chemical lasers with promising nozzle arrays (2020)

Abstract It is shown that the use of a toothed nozzle array in the active medium generator (AMG) of continuous-wave chemical lasers (CWCLs) allows more efficient mixing of reagents to be achieved in the laser chamber than in an AMG with a slit nozzle array. The results of calculations of parameters of the active medium of a DF CWCL operating in the gain regime for the AMG with traditional and promising nozzle array designs are presented. A kinetic model of processes in the DF CWCL active medium is proposed, which allows obtaining a good agreement with the results of measurements of the small-signal gain.
A 2.4GHz CMOS automatic matching network design for pacemaker applications (2009)

This paper presents the design of an adaptive antenna-impedance tuning unit in 0.13 mum CMOS technology. The design is intended for ultra low power medical applications operating at the 2.4 GHz ISM frequency band. It describes the architecture and the design of the different units which are a power amplifier, a pi tunable matching network, an attenuator and a down conversion module with mixer and GmC filter. The automatic matching procedure is simulated and lead to an improvement of 15 dB in the reflection coefficient and an increase of 8 dB in the transmitted power.
Service Robot Management System for Business Improvement and Service Extension (2021)

Service robots are applied in many kinds of business fields and its various kinds of data can be collected with service robot in business scenes. Therefore, it becomes more important to utilize such data for business improvement. Additionally, due to limitation of design such as body size and battery life, a service robot cannot prepare much peripheral equipment on its body. In this paper, we will show two research results as for service robot. One is data analysis technology for business improvement as a function of operation and management system for service robot. Another is service extension of service robot by association of external equipment with proper design of utilization condition of external equipment. Through evaluation experiment, we confirmed potential effect of business improvement is 8.1 % by modifying service scenario of robot.
Quantum critical phenomena in undoped heavy-fermion metals (1996)

We present results of low-temperature calorimetric and resistive measurements on the isostructural heavy-fermion compounds and . `Non-Fermi-liquid' effects are established which suggest the nearness of an antiferromagnetic quantum critical point (QCP) in both systems. The observed deviations from the properties of a Landau Fermi liquid (FL) may be related to anomalous energy dependences of both the quasiparticle mass and the quasiparticle - quasiparticle scattering cross section. For , a moderately heavy FL can be recovered by application of moderate values of either magnetic field or hydrostatic pressure. For p = 1.7 GPa a novel, non-superconducting, phase transition has been discovered at .
Investigation of Longitudinal Power Decay of a MCF by using a 50-km Weakly-Coupled Multi-Core Fibre (2012)

The longitudinal power decay due to crosstalk of a weakly-coupled MCF is observed with bidirectional OTDR technique. The center core and outer cores of MCFs with hexagonal layout show the different crosstalk characteristics until the power of cores is saturated.
Nanoplasmonic Probes of Catalytic Reactions (2009)

Optical probes of heterogeneous catalytic reactions can be valuable tools for optimization and process control because they can operate under realistic conditions, but often probes lack sensitivity. We have developed a plasmonic sensing method for such reactions based on arrays of nanofabricated gold disks, covered by a thin (approximately 10 nanometer) coating (catalyst support) on which the catalyst nanoparticles are deposited. The sensing particles monitor changes in surface coverage of reactants during catalytic reaction through peak shifts in the optical extinction spectrum. Sensitivities to below 10(-3) monolayers are estimated. The capacity of the method is demonstrated for three catalytic reactions, CO and H2 oxidation on Pt, and NO(x) conversion to N2 on Pt/BaO.
Phase II Trial of the Bonn Polychemotherapy Protocol with Deferred Radiotherapy in Patients with Primary Central Nervous System Lymphoma. (2006)

Abstract Objectives: The trial was performed to evaluate response rate, response duration, overall survival, and toxicity in primary central nervous system lymphoma (PCNSL) after systemic and intraventricular chemotherapy with deferred radiotherapy. Patients and Methods: From 09/1995 to 12/2002, 88 patients with PCNSL (median age 62 years) were enrolled onto a pilot/phase II study evaluating chemotherapy without radiotherapy. A high-dose methotrexate (MTX) (cycles 1,2,4,5) and cytarabine (ara-C) (cycles 3,6) based systemic therapy (including dexamethasone, vinca-alkaloids, ifosfamide and cyclophosphamide) was combined with intraventricular MTX, prednisolone and ara-C. Primary endpoint was time to treatment failure (TTF), secondary endpoints were response, overall survival, response duration, 5-year-survival fraction and (neuro)toxicity. Results: Eighty-four of 88 patients were evaluable for response. Of these, 46 (54%) achieved complete response (CR), 4 (5%) complete response/unconfirmed, 8 (10%) partial response (PR), and 14 (17%) progressed under therapy. Seven (8%) out of 84 patients died due to treatment-related complications. In five (6%) of 84 patients therapy had do be discontinued due to severe treatment related complications. Follow-up is one to 124 months (median 42 months). Kaplan Meier estimates for median time to treatment failure (TTF), median overall survival and median response duration are 19 months, 55 months and 37 months respectively. For patients aged 60 years or older, the respective numbers were 9 months, 34 months and 24 months; in patients younger than 60 years Kaplan Meier estimate for TTF is 49 months, median overall survival and median response duration have not been reached yet. The 5-year survival fraction is 72% in patients &lt; 60 years and 24% in older patients. Systemic toxicity was mainly hematologic. Ommaya reservoir infection occurred in 20 (23%) patients. In a subgroup of patients (n=23) treated with chemotherapy alone serial neuropsychological testing showed no chemotherapy related cognitive decline in any patient. However, 8 out of 13 documented elderly patients treated with cranial irradiation as salvage therapy developed severe cognitive deficits. Conclusions: Primary chemotherapy based on high-dose MTX and ara-C is highly efficient in PCNSL. A substantial fraction of patients &lt; 60 years can obviously be cured with this regimen.
Correlations between jets and charged particles in PbPb and pp collisions at sqrt(s[NN])= 2.76 TeV (2016)

The quark-gluon plasma is studied via medium-induced changes to correlations between jets and charged particles in PbPb collisions compared to pp reference data. This analysis uses data sets from PbPb and pp collisions with integrated luminosities of 166 inverse microbarns and 5.3 inverse picobarns, respectively, collected at sqrt(s[NN]) = 2.76 TeV. The angular distributions of charged particles are studied as a function of relative pseudorapidity (Delta eta) and relative azimuthal angle (Delta phi) with respect to reconstructed jet directions. Charged particles are correlated with all jets with transverse momentum (pt) above 120 GeV, and with the leading and subleading jets (the highest and second-highest in pt, respectively) in a selection of back-to-back dijet events. Modifications in PbPb data relative to pp reference data are characterized as a function of PbPb collision centrality and charged particle pt. A centrality-dependent excess of low-pt particles is present for all jets studied, and is most pronounced in the most central events. This excess of low-pt particles follows a Gaussian-like distribution around the jet axis, and extends to large relative angles of Delta eta ~ 1 and Delta phi ~ 1.
Dual Polarization Beamforming Coverage Demonstrated with 5G NR SSB (2021)

Multiple-Input Multiple-Output (MIMO) antennas are increasingly used within cellular systems. They provide flexible beamforming and spatial multiplexing improving coverage and capacity. One drawback with large array antennas is the challenge to provide wide beams utilizing the full power of the MIMO antenna grid. A promising solution is to use dual polarization beamforming. In this paper this technique is demonstrated with a Fifth Generation (5G) New Radio (NR) 8x4 MIMO radio. Dual polarized precoders are designed that utilize all 64 power amplifiers creating a wide sector beam. The coverage is measured on the NR Synchronization Signal Block (SSB) in a macro deployment proving range coverage in combination with a wide horizontal angle.
Immediate Drop on Demand Technology (I-Dot) Coupled with Mass Spectrometry Via an Open Port Sampling Interface (2017)

Aim: The aim of this work was to demonstrate and evaluate the analytical performance of coupling the immediate drop on demand technology to a mass spectrometer via the recently introduced open port sampling interface and ESI. Methodology & results: A maximum sample analysis throughput of 5 s per sample was demonstrated. Signal reproducibility was 10% or better as demonstrated by the quantitative analysis of propranolol and its stable isotope-labeled internal standard propranolol-d7. The ability of the system to multiply charge and analyze macromolecules was demonstrated using the protein cytochrome c. Conclusion: This immediate drop on demand technology/open port sampling interface/ESI–MS combination allowed for the quantitative analysis of relatively small mass analytes and was used for the identification of macromolecules like proteins.
Clinical roundtable monograph: CD30 in lymphoma: its role in biology, diagnostic testing, and targeted therapy. (2014)

CD30, a member of the tumor necrosis factor receptor superfamily, is a transmembrane glycoprotein receptor consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. CD30 has emerged as an important molecule in the field of targeted therapy because its expression is generally restricted to specific disease types and states. The major cancers with elevated CD30 expression include Hodgkin lymphoma and anaplastic large T-cell lymphoma, and CD30 expression is considered essential to the differential diagnosis of these malignancies. Most commonly, CD30 expression is detected and performed by immunohistochemical staining of biopsy samples. Alternatively, flow cytometry analysis has also been developed for fresh tissue and cell aspiration specimens, including peripheral blood and bone marrow aspirate. Over the past several years, several therapeutic agents were developed to target CD30, with varying success in clinical trials. A major advance in the targeting of CD30 was seen with the development of the antibody-drug conjugate brentuximab vedotin, which consists of the naked anti-CD30 antibody SGN-30 conjugated to the synthetic antitubulin agent monomethyl auristatin E. In 2011, brentuximab vedotin was approved by the US Food and Drug Administration for use in Hodgkin lymphoma and anaplastic large cell lymphoma based on clinical trial data showing high response rates in these indications. Ongoing trials are examining brentuximab vedotin after autologous stem cell transplantation, as part of chemotherapy combination regimens, and in other CD30-expressing malignancies, including primary mediastinal large B-cell lymphomas, diffuse large B-cell lymphoma, lymphoma positive for Epstein-Barr virus, peripheral T-cell lymphoma not otherwise specified, and cutaneous anaplastic large cell lymphoma.
Optimal duration of neoadjuvant androgen withdrawal therapy before radical prostatectomy in clinically confined prostate cancer. (1996)

Experimental studies have shown that neoadjuvant androgen therapy dramatically reduces the rate of local recurrence after tumor excision. In the clinical setting, a 3-month course of neoadjuvant therapy before radical prostatectomy has been shown to significantly reduce positive margin rates, but follow-up is too short to assess the impact of such therapy on biochemical and clinical recurrence rates. A phase II study using an ultrasensitive assay showed that 8 months of neoadjuvant therapy were required before prostate-specific antigen (PSA) levels to reach their nadir in 84% of study participants. The positive margin rate in this study was substantially lower than those reported in the literature. Importantly, restaging of specimens after prostatic acid phosphatase (PAP) immunostaining did not upstage or increase positive margin rates. In addition, prolonged neoadjuvant therapy did not appear to result in progression of androgen-independent clones. A randomized phase III trial has been initiated to determine whether an 8-month course of neoadjuvant hormonal therapy is superior to a 3-month course in reducing positive margin rates and biochemical recurrences in patients with clinically confined prostate cancer.
Control of the selectivity in multi-functional group molecules using supported gold–palladium nanoparticles (2013)

The oxidation of 2-hexen-1-ol and 1-hexen-3-ol with air has been studied using supported gold, palladium and gold–palladium catalysts. The main aim was to determine if either the alcohol or alkene functional group can be oxidised selectively. However, based on the reaction products observed (2-hexen-1-ol forms 2-hexene, hexanal, (E)-2-hexenal, (E)-3-hexen-1-ol, 4-hexen-1-ol and (E)-2-hexanoic acid. 1-Hexen-3-ol forms 1-hexene, 3-hexanone, 1-hexen-3-one and 3-hexenol), the main pathway in these reactions is isomerisation and, in addition, significant yields of the products are due to a disproportionation reaction. Controlling the selectivity in molecules with multiple function groups by manipulating the catalyst composition and reaction conditions can promote or hinder the various reaction pathways, thereby increasing the selectivity to the desired oxidation products.
Discovering Sparse Interpretable Dynamics from Partial Observations (2021)

Identifying the governing equations of a nonlinear dynamical system is key to both understanding the physical features of the system and constructing an accurate model of the dynamics that generalizes well beyond the available data. We propose a machine learning framework for discovering these governing equations using only partial observations, combining an encoder for state reconstruction with a sparse symbolic model. Our tests show that this method can successfully reconstruct the full system state and identify the underlying dynamics for a variety of ODE and PDE systems.