gebhart/patrepeval huggingface dataset:
THE EFFECTS OF LOW DENSITY LIPOPROTEINS ON UPTAKE OF PHOTOFRIN II (1990)

The cellular uptake of Photofrin II (PII) was studied using fluorescence imaging and chemical extraction. The influence of serum and low density lipoproteins (LDL) was examined under a variety of experimental conditions employing cultured human cells of different origins as well as a subcutaneously SMT-F tumor implanted in mice. Results showed that serum inhibited PII uptake. In general, LDL also inhibits PII uptake with the exception of an initial increase in the first 10-30 min when the cellular concentration of PII was measured by fluorescence imaging instead of chemical extraction. Our results suggest a possible de-aggregation process occurring upon internalization or binding of PII to LDL.
A Proposal for a Three Detector Short-Baseline Neutrino Oscillation Program in the Fermilab Booster Neutrino Beam (2015)

A Short-Baseline Neutrino (SBN) physics program of three LAr-TPC detectors located along the Booster Neutrino Beam (BNB) at Fermilab is presented. This new SBN Program will deliver a rich and compelling physics opportunity, including the ability to resolve a class of experimental anomalies in neutrino physics and to perform the most sensitive search to date for sterile neutrinos at the eV mass-scale through both appearance and disappearance oscillation channels. Using data sets of 6.6e20 protons on target (P.O.T.) in the LAr1-ND and ICARUS T600 detectors plus 13.2e20 P.O.T. in the MicroBooNE detector, we estimate that a search for muon neutrino to electron neutrino appearance can be performed with ~5 sigma sensitivity for the LSND allowed (99% C.L.) parameter region. In this proposal for the SBN Program, we describe the physics analysis, the conceptual design of the LAr1-ND detector, the design and refurbishment of the T600 detector, the necessary infrastructure required to execute the program, and a possible reconfiguration of the BNB target and horn system to improve its performance for oscillation searches.
2019年版 透析排水基準 (2019)

78.7％)施設は透析排水に基準があ ることを知りながら何ら対策を講じていないことも明らかとなった． 公共下水道への排水に関しては
Misoprostol and Gastrointestinal Complications in Patients Taking Nonsteroidal Anti-Inflammatory Drugs for Rheumatoid Arthritis (1996)

Letters15 May 1996Misoprostol and Gastrointestinal Complications in Patients Taking Nonsteroidal Anti-Inflammatory Drugs for Rheumatoid ArthritisFred E. Silverstein, MD and G. Steven Geis, PhD, PhD, MDFred E. Silverstein, MDUniversity of Washington Medical School, Seattle, WA 98195G. D. Searle & Co. Skokie, IL 60077Search for more papers by this author and G. Steven Geis, PhD, PhD, MDUniversity of Washington Medical School, Seattle, WA 98195G. D. Searle & Co. Skokie, IL 60077Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-10-199605150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate the responses to our article [1]. We agree that the concept of NNT raised by Dr. Wendel and by Madhok and colleagues is important. Using the formula NNT = 1/(riskplacebo − riskmisoprostol), we determined that the NNT was 263 for the 67 serious NSAID-related gastrointestinal events we observed. For those patients at higher risk, however, the NNT to avert a gastrointestinal complication becomes much smaller. For example, for patients with previous peptic ulcer disease, the NNT is 53.We recently completed additional analyses of the 242 events reported as suspected NSAID-induced complications. These events include patients ...References1. Silverstein FE, Graham DY, Senior JR, Wyn Davies H, Struthers BJ, Bittman RM, et al. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1995; 123:241-9. Google Scholar2. Simon LS, Polisson RP, Hatoum HT, Bittman RM. Risk factors for serious nonsteroidal induced GI complications: the risk reduction effect of misoprostol therapy in the individual “at-risk” patient. Arthritis Rheum. 1995; 38(Suppl):S206. Google Scholar3. Raskin JB, White RH, Jackson JE, Weaver AL, Tindall EA, Lies RB, et al. Misoprostol dosage in the prevention of nonsteroidal anti-inflammatory drug-induced gastric and duodenal ulcers: a comparison of three regimens. Ann Intern Med. 1995; 123:344-50. Google Scholar Author, Article, and Disclosure InformationAuthors: Fred E. Silverstein, MD; G. Steven Geis, PhD, PhD, MDAffiliations: University of Washington Medical School, Seattle, WA 98195G. D. Searle & Co. Skokie, IL 60077 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1996Volume 124, Issue 10Page: 927KeywordsDrugsHealth care utilizationHemorrhageHospitalizationsNSAIDsNumber needed to treatPeptic ulcersPopulation statisticsRheumatoid arthritisUlcers ePublished: 15 August 2000 Issue Published: 15 May 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5 (2007)

MicroRNAs (miRNAs) have been implicated in sequence-specific cleavage, translational repression or deadenylation of specific target mRNAs resulting in post-transcriptional gene silencing. Epstein-Barr virus (EBV) encodes 23 miRNAs of unknown function. Here we show that the EBV-encoded miRNA miR-BART2 down-regulates the viral DNA polymerase BALF5. MiR-BART2 guides cleavage within the 3'-untranslated region (3'UTR) of BALF5 by virtue of its complete complementarity to its target. Induction of the lytic viral replication cycle results in a reduction of the level of miR-BART2 with a strong concomitant decrease of cleavage of the BALF5 3'UTR. Expression of miR-BART2 down-regulates the activity of a luciferase reporter gene containing the BALF5 3'UTR. Forced expression of miR-BART2 during lytic replication resulted in a 40-50% reduction of the level of BALF5 protein and a 20% reduction of the amount of virus released from EBV-infected cells. Our results are compatible with the notion that EBV-miR-BART2 inhibits transition from latent to lytic viral replication.
Shock Synthesis of Decagonal Quasicrystals (2017)

The Khatyrka meteorite contains both icosahedral and decagonal quasicrystals. In our previous studies, icosahedral quasicrystals have been synthesized and recovered from shock experiments at the interface between CuAl<sub>5</sub> and stainless steel 304 alloys. In this study, we report a new shock recovery experiment aimed at synthesizing decagonal quasicrystals similar to decagonite, natural Al<sub>71</sub>Ni<sub>24</sub>Fe<sub>5</sub>. Aluminum 2024 and permalloy 80 alloys were stacked together and shocked in a stainless steel 304 recovery chamber. Abundant decagonal quasicrystals of average composition Al<sub>73</sub>Ni<sub>19</sub>Fe<sub>4</sub>Cu<sub>2</sub>Mg<sub>0.6</sub>Mo<sub>0.4</sub>Mn<sub>0.3</sub> with traces of Si and Cr were found along the recovered interface between the Al and permalloy. The experiment also synthesized AlNiFe alloy with the B2 (CsCl-type) structure and the metastable Al<sub>9</sub>Ni<sub>2</sub> phase. We present chemical (scanning electron microscopy and electron microprobe) and structural (electron backscatter diffraction and transmission electron microscopy) characterization of the recovered phases and discuss the implications of this shock synthesis for the stability of quasicrystals during high-pressure shocks and for the interpretation of the phase assemblage found in Khatyrka.
Aspergillus ustusInfections among Transplant Recipients (2006)

Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported. We report the first outbreak of invasive infection caused by A. ustus among hematopoietic stem cell transplant (HSCT) recipients. Six patients with infections were identified; 3 infections each occurred in both 2001 and 2003. Molecular typing by using randomly amplified polymorphic DNA (RAPD) and antifungal drug susceptibility testing were performed on clinical and environmental isolates recovered from our hospital from 1999 to 2003. The highest overall attack rate in HSCT patients was 1.6%. The overall death rate was 50%, and death occurred within 8 days after diagnostic culture collection. Clinical isolates exhibited decreased susceptibility to antifungal drugs, especially azoles. RAPD and phylogenetic analysis showed genetic similarity between isolates from different patients. Based on the clustering of cases in space and time and molecular data, common-source acquisition of this unusual drug-resistant species is possible.
Computer-aided facial reconstruction using skulls (2007)

The ability to determine the identity of a skull found at a crime scene is of critical importance to the law enforcement community. Traditional clay-based methods attempt to reconstruct the face so as to enable identification of the deceased by members of the general public. However, these reconstructions lack consistency from practitioner to practitioner and it has been shown that the human recognition of these reconstructions against a photo gallery of potential victims is little better than chance. In this talk we discuss the automation of the reconstruction process. For a given skull, a data-driven 3D generative model of the face is constructed using a database of CT head scans. The reconstruction can be constrained based on prior knowledge such as age and or weight. To determine whether or not these reconstructions have merit, geometric methods for comparing reconstructions against a gallery of facial images are proposed. First, active appearance models are used to automatically detect a set of facial landmarks on each image. These landmarks are associated with 3D points on the reconstruction. Direct comparison of the reconstruction is problematic since in general the camera geometry used for image capture is unknown and there are uncertainties associated with the reconstruction and landmark detection processes. The first method of comparison uses constrained optimization to determine the optimal projection of the reconstruction on to the image. Residuals are then analyzed resulting in a ranking of the gallery. The second method uses boosting to learn which points are both reliable and discriminating. This results in a match/no-match classifier. Experimental evidence indicating that skull recognition from facial images can be achieved is presented.
Ultrastructural Surface Characterization of Cultured Intracranial Tumors (1976)

One property of a malignant cell is its decreased intercellular adhesiveness in vivo(l), and in vitro(2). In an attempt to visualize any morphological correlates associated with this phenomenon we utilized the replica technique to examine cell surfaces and cell to substrate attachment regions in cultured intracranial tumors, tumors from other sites and reactive cells. Cells were explanted onto glass coverslips in Leighton tubes, cultured to approximately 50% confluency, buffer rinsed, 2.5% glutaraldehyde fixed, chrome-osmium postfixed, critical point dried with Freon 13 and 113, and replicated with platinum carbon. The cells and coverslips were dissolved away by hydroflouric acid.
Data from MR-Guided Near-Infrared Spectral Tomography Increases Diagnostic Performance of Breast MRI (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; The purpose of this study was to determine the diagnostically most important molecular biomarkers quantified by magnetic resonance-guided (MR) near-infrared spectral tomography (NIRST) that distinguish malignant breast lesions from benign abnormalities when combined with outcomes from clinical breast MRI.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; The study was HIPAA compliant and approved by the Dartmouth Institutional Review Board, the NIH, the United States State Department, and Xijing Hospital. MR-guided NIRST evaluated hemoglobin, water, and lipid content in regions of interest defined by concurrent dynamic contrast-enhanced MRI (DCE-MRI) in the breast. MRI plus NIRST was performed in 44 subjects (median age, 46, age range, 20–81 years), 28 of whom had subsequent malignant pathologic diagnoses, and 16 had benign conditions. A subset of 30 subject examinations yielded optical data that met minimum sensitivity requirements to the suspicious lesion and were included in the analyses of diagnostic performance.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; In the subset of 30 subject examinations meeting minimum optical data sensitivity criterion, the MR-guided NIRST separated malignant from benign lesions using total hemoglobin (HbT; &lt;i&gt;P&lt;/i&gt; &lt; 0.01) and tissue optical index (TOI; &lt;i&gt;P&lt;/i&gt; &lt; 0.001). Combined MRI plus TOI data caused one false positive and 1 false negative, and produced the best diagnostic performance, yielding an AUC of 0.95, sensitivity of 95%, specificity of 89%, positive predictive value of 95%, and negative predictive value of 89%, respectively.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; MRI plus NIRST results correlated well with histopathologic diagnoses and could provide additional information to reduce the number of MRI-directed biopsies. &lt;i&gt;Clin Cancer Res; 21(17); 3906–12. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Suppression of Lethal Ischemic Ventricular Arrhythmias by the Class III Agent E4031 in a Canine Model of Previous Myocardial Infarction (1990)

The antiarrhythmic efficacy of a new and potent class III agent E4031 [1-[2-(6-methyl-2-pyridyl)-ethyl]-4-(4- methylsulfonylaminobenzoyl)piperidine] was evaluated in several canine models of recent myocardial infarction. In anesthetized dogs with baseline inducible ventricular arrhythmias studied 4-10 days after anterior myocardial infarction, 30-300 micrograms/kg i.v. E4031 suppressed induction of ventricular tachyarrhythmias by programmed ventricular stimulation in 7 of 10 animals tested, while significantly prolonging refractoriness in both noninfarcted and infarcted ventricular myocardium. The incidence of lethal ischemic ventricular arrhythmias developing in response to acute posterolateral myocardial ischemia in the presence of previous anterior infarction was reduced from 10 of 10 (100%) in a vehicle pretreatment group to 3 of 10 (30%, p less than 0.01) in an E4031 (300 micrograms/kg intravenously, i.v.) pretreatment group. Neither the sizes of the underlying anterior myocardial infarctions (26.9 +/- 3.7 vs. 33.2 +/- 2.1% of left ventricle) nor the times to development of acute posterolateral myocardial ischemia (43 +/- 11 vs. 40 +/- 8 min) differed significantly between the vehicle and E4031 pretreatment groups, respectively, suggesting that the reduction in the incidence of lethal ischemic arrhythmias in the E4031 pretreatment group was not due to smaller underlying, electrically unstable myocardial substrates nor to a delay in onset of the acute ischemic insult. In conscious dogs with spontaneous ventricular ectopy at 48 h after myocardial infarction and in anesthetized dogs with no baseline inducible arrhythmias at 4-10 days after myocardial infarction, E4031 (30-3,000 micrograms/kg i.v.) produced no facilitation or aggravation of spontaneous or inducible ventricular arrhythmias. These findings suggest that pharmacologic agents such as E4031 that increase ventricular refractoriness (class III electrophysiologic activity) may provide significant protection against development of malignant ischemic ventricular arrhythmias in the setting of previous myocardial infarction.
Dynamic changes in the receptive fields of L1-type horizontal cells in the retina of the turtle Mauremys caspica (2002)

The resistances of the horizontal cell syncytium in the vertebrate retina are modulated in a time-dependent fashion during light stimulation. Therefore, the spatial properties of horizontal cells are expected to change with time after the illumination conditions are altered. This study was designed to investigate time- and intensity-dependent changes in the receptive-field properties of L1-type horizontal cells in the turtle Mauremys caspica. Photoresponses were elicited by monochromatic (650 nm) light stimuli of 2-s duration covering retinal spots of different radii. The length constants were derived from the relationships between amplitude and spot radius that were constructed for different time intervals after onset of the light stimulus. For a given stimulus intensity, the length constant transiently increased to a peak value and then slowly recovered to a plateau level. When the length constant was compared to the amplitude of the response to full-field illumination for the entire duration of the light stimulus, an ellipse-like curve was obtained indicating that for a given membrane potential, two different values of the length constant could be obtained. Dopamine considerably reduced the size of the receptive fields but did not affect the time-dependent changes in the length constant. These results indicate that changes in the membrane resistance underlie short-term modulation of the receptive-field properties of turtle L1-type horizontal cells after onset of a light stimulus.
The impact of finite bandwidth on PRBS-modulated optical spectra (2022)

This paper reveals some limitations from the practical implementation of applying the pseudo-random binary sequence (PRBS) method to the modulation of optical spectra as a means to increase stimulated Brillouin scattering threshold in high power lasers.
Vaginoplasty using autologous in vitro cultured vaginal tissue in a patient with Mayer-von-Rokitansky-Kuster-Hauser syndrome (2007)

Mayer-von-Rokitansky-Küster-Hauser syndrome (MRKHS) is characterized by vaginal agenesis with variable Müllerian duct abnormalities. The Abbè-McIndoe technique is considered a valid treatment option for vaginoplasty but no consensus has been reached on what material should be used for the neovagina canal wall lining. We report the first case of autologous vaginal tissue transplantation in a 28-year-old women with MRKHS. The patient was subjected to a 1 cm2 full-thickness mucosal biopsy from the vaginal vestibule. Following enzymatic dissociation, cells were inoculated onto collagen IV-coated plates and cultured for 2 weeks. The patient was subjected to a vaginoplasty with a modified Abbè-McIndoe vaginoplasty with 314 cm2 autologous in vitro cultured vaginal tissue for the canal lining. At 1 month from surgery, the vagina appeared normal in length and depth and a vaginal biopsy revealed normal vaginal tissue. The use of autologous in vitro cultured vaginal tissue to create a neovagina appears as an easy, minimally invasive and useful method.
Preparation of [11C]methyl nona‐fluorobutyl‐1‐sulfonate ([11C]MeONf) and its use in the synthesis of [11C]‐6‐OH‐BTA‐1 (2007)

Abstract The rapid, simple and high‐yield synthesis of the extraordinarily reactive 11 C‐methylating agent, [ 11 C]methyl nona‐fluorobutyl‐1‐sulfonate ([ 11 C]MeONf), and its use in the synthesis of the promising β‐amyloid imaging agent, [ 11 C]‐6‐OH‐BTA‐1, is reported. In terms of radioactive methylation yields, [ 11 C]MeONf seems to surpass [ 11 C]methyl trifluoromethansulfonate ([ 11 C]MeOTf) as a methylating agent in this particular case giving the 11 C‐labelled compound in high‐preparative radiochemical yields between 27 and 29% EOS with a minimum formation of radioactive by‐products. Copyright © 2007 John Wiley &amp; Sons, Ltd.
Reconfigurable state-machine oriented flow-based router design (2005)

Traditional Internet protocol (IP) address lookup is one of the major performance bottlenecks in high-end routers. Prior art has investigated into architectures for flow-based IP address lookup engines based on programmable finite state machines (FSMs), which when implemented in a regular structured hardware engine, has led to the classical update problem in improving the reprogramming time of each machine and effective scheduling of the individual machines in the context of router database update. This paper describes a distributed co-evolving architecture that looks into the issue of an optimal hardware-software partition for flow-based routing from the viewpoint of memory and resource optimizations.
Organocatalytic Diastereo‐ and Enantioselective Michael Addition Reactions of 5‐Aryl‐1,3‐dioxolan‐4‐ones. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel metal/semiconductor nanocomposite and superlattice materials and devices for thermoelectrics (2010)

Efficiency of thermoelectric materials is generally discussed in terms of the dimensionless figure-of-merit, ZT = S<sup>2</sup>&sigma;T/&kappa;, Many researchers have found that it is possible to reduce the lattice thermal conductivity by incorporating nanostructures (i.e. nanoparticles or heterobarriers) into materials, thereby scattering phonons. At the same time, it has been theoretically predicted and experimentally demonstrated that barriers can be used to "filter" the distribution of carriers which contribute to conduction. By doing so, it is possible to significantly increase the Seebeck coefficient while only modestly decreasing the electrical conductivity. As a result of this energy-dependent scattering of carriers, the thermoelectric power factor is increased. We present theoretical and experimental results for metal/semiconductor nanocomposites consisting of metallic rareearth- group V nanoparticles within III-V semiconductors (e.g. ErAs:InGaAlAs) demonstrating both an increase in thermoelectric power factor and a decrease in thermal conductivity, resulting in a large figure of merit. We also discuss metal/semiconductor superlattices made of lattice-matched nitride materials for electron filtering and the prospects of these materials for efficient thermoelectrics, especially at high temperatures. Finally, we will discuss both various synthesis techniques for these materials, including the prospects for bulk growth, and also devices fabricated from these materials.
Phosphoramidite-Controlled Asymmetric Hydrogenation with Rhodium Catalysts (2006)

Phosphoramidites, and in particular those derived from BINOL, the MonoPhos family of ligands, have proven extremely useful for the asymmetric hydrogenation of carbon-carbon unsaturation using a rhodium catalyst. Many classes of alkenes can be reduced by these catalyst systems. The use of high-throughput experimentation can be applied to the synthesis of MonoPhos ligands and their subsequent screening, in order to find an appropriate candidate for a specific transformation. Suitable mixtures of ligands can also be found by these high-throughput methods.
Industrially Viable Syntheses of Highly Enantiomerically Enriched 1-Aryl Alcohols via Asymmetric Hydrogenation (2002)

The practicalities of the asymmetric hydrogenation of acetophenone derivatives are addressed. The catalysts used, derived from the precatalysts [(xylylPhanePhos)RuCl2(DPEN)] (S)-(R,R)-1 and (R)-(S,S)-1, were shown to possess very high reactivity. 4'-Fluoroacetophenone was hydrogenated at a molar substrate-to-catalyst ratio (S/C) of 100,000 with complete conversion effected in as little as 80 min (average turnover ∼1200 min-1, peak turnover ∼2500 min-1). The catalysts are tolerant of a range of commercial grade substrates, in most cases a S/C of 5000−10000 was achieved without the need to purify the ketone. Using precatalyst 1 enantioselectivities of 95 → 99% ee were achieved. The high selectivity and catalyst activity, plus the simplicity of the process, offers significant advantages over other enantioselective ketone reductions.