gebhart/patrepeval huggingface dataset:
Redfish-Nagios (2022)

Current monitoring tools for high-performance computing (HPC) systems are often inefficient in terms of scalability and interfacing with modern data center management APIs. This inefficiency leads to a lack of effective management of infrastructure of modern data centers. Nagios is one of the widely used industry-standard tools for data center infrastructure monitoring, which mainly include monitoring of nodes and associated hardware and software components. However, current Nagios monitoring has special requirements that introduce several limitations. First, a significant human effort is needed for the configuration of monitored nodes in the Nagios server. Second, the Nagios Remote Plugin Executor and the Nagios Service Check Acceptor are required on the Nagios server and each monitored node for active and passive monitoring, respectively. Third, Nagios monitoring also requires monitoring-specific agents on each monitored node. These shortcomings are inherently due to Nagios' in-band implementation nature. To overcome these limitations, we introduced Redfish-Nagios, a scalable out-of-band monitoring tool for modern HPC systems. It integrates the Nagios server with the out-of-band Distributed Management Task Force's Redfish telemetry model, which is implemented in the baseboard management controller of the nodes. This integration eliminates the requirements of any agent, plugin, hardware component, or configuration on the monitored nodes. It is potentially a paradigm shift in Nagios-based monitoring for two reasons. First, it simplifies communication between the Nagios server and monitored nodes. Second, it saves the computational cost by removing the requirements of running complex Nagios-native protocols and agents on the monitored nodes. The Redfish-Nagios integration methodology enables monitoring of next-generation HPC systems using the scalable and modern Redfish telemetry model and interface.
Hydrogen Production From Heavy Fuels (1984)

Better heat transfer properties avoid sulfur poisoning of catalyst. Monolithic supported catalyst allows initiation of steam reforming to take place more rapidly at inlet section of reactor.
Modeling and Analysis of Non-Rectangular Gate for Post-Lithography Circuit Simulation (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Human characterization and tracking using pyroelectric sensors (2005)

A network of common pyroelectric motion sensors that can track and identify human targets has been developed using low-cost, commercially available components. Significantly cheaper than deploying infrared imaging systems and considerably more advanced than typical motion sensing systems, this system consists of a small number of sensor nodes distributed across a medium sized room. Each node contain up to eight pyroelectric detectors and provides limited computation and communication capabilities. These detectors use structured lenslets to extract frequency components of targets for classification and the location and orientation of the sensors is used to track targets as they move through the space. This system has demonstrated multiple target tracking and the bility to differentiate between multiple people.
The Proto-oncoprotein SYT Interacts with SYT-interacting Protein/Co-activator Activator (SIP/CoAA), a Human Nuclear Receptor Co-activator with Similarity to EWS and TLS/FUS Family of Proteins (2005)

The proto-oncoprotein SYT is involved in the unique translocation t(X;18) found in synovial sarcoma SYT-SSX fusions. SYT has a conserved N-terminal domain (SNH domain) that interacts with the human paralog of Drosophila Brahma (hBRM) and Brahma-related gene 1 (BRG1) chromatin remodeling proteins and a C-terminal transactivating sequence rich in glutamine, proline, glycine, and tyrosine (QPGY domain). Here we reported the isolation of the ribonucleoprotein SYT-interacting protein/co-activator activator (SIP/CoAA), which specifically binds the QPGY domain of SYT and also the SYT-SSX2 translocation fusion. SIP/CoAA is a general nuclear co-activator and an RNA splicing modulator that contains two RNA recognition motifs and multiple hexapeptide repeats. We showed that the region consisting of the hexapeptide motif (YQ domain) is similar to the hexapeptide repeat domain found in EWS and in TLS/FUS family proteins. The YQ domain also resembles the QPGY region of SYT itself and like all these other domains acts as a transcriptional activator in reporter assays. Most interestingly, the last 84 amino acids adjacent to YQ down-modulate by 25-fold the YQ transactivation of the reporter gene, and both domains are important for SIP/CoAA binding to SYT. In addition, SYT acts together with SIP/CoAA in stimulating estrogen and glucocorticoid receptor-dependent transcriptional activation. Activation is hormone-dependent and requires functional hBRM and/or BRG1. The stimulation is strongly reduced if the N-terminal region of hBRM/BRG1 (amino acids 1-211) is deleted. This region encompasses the SNF11 binding domain (amino acids 156-211), which interacts specifically with SYT in vivo and in vitro.
Efficient spectrum utilization: Cognitive radio approach (2013)

This paper presents a brief overview of cognitive radio applications and discusses design challenges in implementing integrated circuits for spectrum sensing and wideband/reconfigurable transceivers. Our prototype chip of a cognitive radio receiver with multi-resolution, dynamic-range-scalable spectrum sensing capability over a wide frequency range of 30 MHz to 2.4 GHz is also described.
32-Phosphorus selectively delivered by listeria to pancreatic cancer demonstrates a strong therapeutic effect (2017)

Our laboratory has developed a novel delivery platform using an attenuated non-toxic and non-pathogenic bacterium Listeria monocytogenes that infects tumor cells and selectively survives and multiplies in metastases and primary tumors with help of myeloid-derived suppressor cells (MDSC) and immune suppression in the tumor microenvironment (TME). 32P was efficiently incorporated into the Listeria bacteria by starvation of the bacteria in saline, and then cultured in phosphorus-free medium complemented with 32P as a nutrient. Listeria-32P kills tumor cells through both 32P-induced ionizing radiation and Listeria-induced reactive oxygen species (ROS). The levels of 32P and Listeria were studied in various normal and tumor tissues, at sequential time points after injection of mice with pancreatic cancer (syngeneic model Panc-02). We found that 32P and Listeria predominantly accumulated in tumors and metastases, with their highest accumulation 4 hrs (32P) and 3 days (Listeria) after injection. Listeria also penetrated the transgenic KPC (conditionally express endogenous Kras-G12D and p53-R172H mutant alleles) pancreatic tumors and metastases. This is remarkable since KPC tumors, like human tumors, exhibit a stromal barrier, which prevents most drugs from penetrating the pancreatic tumors. Therapeutic treatment with Listeria -32P resulted in a strong reduction of the growth of pancreatic cancer at early and late stages in Panc-02 and KPC mice. These results highlight the power of Listeria as new delivery platform of anticancer agents to the TME. Not only were therapeutic levels of radioactive Listeria reached in tumors and metastases but the selective delivery also led to minimal side effects.
A Parameterization Scheme for Lossy Transmission Line Macromodels With Application to High Speed Interconnects in Mobile Devices (2007)

We introduce a novel parameterization scheme based on the generalized method of characteristics (MoC) for macromodels of transmission-line structures having a cross section depending on several free geometrical and material parameters. This situation is common in early design stages, when the physical structures still have to be finalized and optimized under signal integrity and electromagnetic compatibility constraints. The topology of the adopted line macromodels has been demonstrated to guarantee excellent accuracy and efficiency. The key factors are propagation delay extraction and rational approximations, which intrinsically lead to a SPICE-compatible macromodel stamp. We introduce a scheme that parameterizes this stamp as a function of geometrical and material parameters such as conductor-width and separation, dielectric thickness, and permittivity. The parameterization is performed via multidimensional interpolation of the residue matrices in the rational approximation of characteristic admittance and propagation operators. A significant advantage of this approach consists of the possibility of efficiently utilizing the MoC methodology in an optimization scheme and eventually helping the design of interconnects. We apply the proposed scheme to flexible printed interconnects that are typically found in portable devices having moving parts. Several validations demonstrate the effectiveness of the approach
Fast Prototyping of an L-band Array Using Additive and Subtractive Techniques (2023)

A well performing and novel L-band array for GPS application is designed for fabrication using primarily additive manufacturing. The aperture is comprised of inverted-F antennas (IFAs) fabricated by copper plating 3D printed elements in stereolithography. To achieve right-hand circular polarization, a three-layer meanderline polarizer (MLP) is designed and integrated in a hybrid fashion with 3D printed low-permittivity “foam-like” spacers built by fused deposition modeling. The base plate and supporting frame are also 3D printed with the former covered in aluminum foil to achieve RF grounding for the entire system. To further reduce prototyping time, a superstrate, placed between the IFAs and the first MLP layer is fabricated in-house using conventional subtractive machining. The MLP layers are copper etched on Kapton though can be realized using conductive trace printing in future works. Measurements and simulations show active mismatch loss < 0.5 dB, axial ratio < 2 dB, and aperture efficiency > 63% at the GPS L1, L2, and L5 bands with dual-band axial ratio < 3 dB bandwidth from 1.075-1.275 and 1.5-1.7 GHz.
Study of On-Board Calculation of Road Gradient. (1997)

It is desirable to change the shift schedule of an automatic transmission according to the road gradient. We previously developed a drive torque calculation method, and used it to calculate the gradient of a road as which a car was traveling. Gradient resistance torque is calculated by subtraction of the acceleration torque and road load torque from the drive torque. By improvement of the detection method for determining vehicle speed and the masking method for eliminating interruption by braking, a gradient calculation accuracy of ±20% is obtained. This is not a as good as in the case of use of the conventional sensing method, but the new method can be implemented without a torque sensor. We studied the possibility of applying this control with the presnt ±20% error. Control can be realized when this road gradient calculation method is used together with another parameter to judge the control situation.
Novel Selective Allosteric Activator of the M1Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in Rats (2008)

Recent studies suggest that subtype-selective activators of M(1)/M(4) muscarinic acetylcholine receptors (mAChRs) may offer a novel approach for the treatment of psychotic symptoms associated with schizophrenia and Alzheimer's disease. Previously developed muscarinic agonists have provided clinical data in support of this hypothesis, but failed in clinical development because of a lack of true subtype specificity and adverse effects associated with activation of other mAChR subtypes. We now report characterization of a novel highly selective agonist for the M(1) receptor with no agonist activity at any of the other mAChR subtypes, termed TBPB [1-(1'-2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one]. Mutagenesis and molecular pharmacology studies revealed that TBPB activates M(1) through an allosteric site rather than the orthosteric acetylcholine binding site, which is likely critical for its unprecedented selectivity. Whole-cell patch-clamp recordings demonstrated that activation of M(1) by TBPB potentiates NMDA receptor currents in hippocampal pyramidal cells but does not alter excitatory or inhibitory synaptic transmission, responses thought to be mediated by M(2) and M(4). TBPB was efficacious in models predictive of antipsychotic-like activity in rats at doses that did not produce catalepsy or peripheral adverse effects of other mAChR agonists. Finally, TBPB had effects on the processing of the amyloid precursor protein toward the non-amyloidogenic pathway and decreased Abeta production in vitro. Together, these data suggest that selective activation of M(1) may provide a novel approach for the treatment of symptoms associated with schizophrenia and Alzheimer's disease.
Biocompatibility and pathways of initial complement pathway activation with Phisio- and PMEA-coated cardiopulmonary bypass circuits during open-heart surgery (2010)

A randomized open-heart surgery study comprising 30 patients was undertaken to compare the biocompatibility of Phisio-(phosphorylcholine) and PMEA-(poly-2-methoxyethyl acrylate) coated cardiopulmonary bypass (CPB) circuits and to assess the initial complement pathway activation during open-heart surgery. Blood samples were obtained at five time points, from the start of surgery to 24 hours postoperatively. The following analyses were performed: haemoglobin, lactate dehydrogenase, leukocyte and platelet counts, myeloperoxidase and neutrophil-activating peptide-2, thrombin-anti-thrombin complexes, syndecan-1 and the complement activation products C1rs-C1-inhibitor complexes, C4bc, C3bc, C3bBbP and the terminal complement complex (TCC). No significant inter-group difference was found in any parameters, except for the concentration of TCC which was moderately lower in the PMEA group at termination of CPB. Complement activation during open-heart surgery was mainly mediated through the alternative pathway. In conclusion, PMEA- and Phisio-coated circuits displayed similar biocompatibility with respect to inflammatory and haemostatic responses during and after open-heart surgery.
Phenotypic performance of nine genotypes of Cry1A.105/Cry2Ab2 dual‐gene resistant fall armyworm on non‐Bt and MON 89034 maize (2019)

The fitness of individual resistant genes on pyramided Bt plants varied in the dual-gene resistance system. Genotypes containing more Cry1A.105 RAs performed better than those possessing more Cry2Ab2 RAs. The functional dominance level of an individual resistant gene in this system is related to the D<sub>ML</sub> level in its corresponding single-gene system. Data generated from this study should fill gaps in understanding dual-/multiple-gene Bt resistance, as well as providing useful information for refining resistance modeling, improving resistance risk assessment, and developing management strategies for the sustainable use of pyramided Bt maize technology. © 2019 Society of Chemical Industry.
A Linear Model for Nonlinear Phase Noise Induced by Cross-phase Modulation (2009)

A simplified linear model is developed to predict nonlinear phase noise induced by cross-phase modulation (XPM). The simplified model shows good agreement with experiment and provides various insights on XPM phenomena.
Obesity is the predominant predictor of impaired glucose tolerance and metabolic disturbance in polycystic ovary syndrome (2012)

Body weight status was the major factor determining the risk of impaired glucose tolerance and metabolic syndrome in women with PCOS. Obesity should be treated as the major factor determining long-term health consequences associated with PCOS.
Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death (2018)

Cancer cells lose homeostatic flexibility because of mutations and dysregulated signaling pathways involved in maintaining homeostasis. Tuberous Sclerosis Complex 1 (TSC1) and TSC2 play a fundamental role in cell homeostasis, where signal transduction through TSC1/TSC2 is often compromised in cancer, leading to aberrant activation of mechanistic target of rapamycin complex 1 (mTORC1). mTORC1 hyperactivation increases the basal level of endoplasmic reticulum (ER) stress via an accumulation of unfolded protein, due to heightened de novo protein translation and repression of autophagy. We exploit this intrinsic vulnerability of tumor cells lacking TSC2, by treating with nelvinavir to further enhance ER stress while inhibiting the proteasome with bortezomib to prevent effective protein removal. We show that TSC2-deficient cells are highly dependent on the proteosomal degradation pathway for survival. Combined treatment with nelfinavir and bortezomib at clinically relevant drug concentrations show synergy in selectively killing TSC2-deficient cells with limited toxicity in control cells. This drug combination inhibited tumor formation in xenograft mouse models and patient-derived cell models of TSC and caused tumor spheroid death in 3D culture. Importantly, 3D culture assays differentiated between the cytostatic effects of the mTORC1 inhibitor, rapamycin, and the cytotoxic effects of the nelfinavir/bortezomib combination. Through RNA sequencing, we determined that nelfinavir and bortezomib tip the balance of ER protein homeostasis of the already ER-stressed TSC2-deficient cells in favor of cell death. These findings have clinical relevance in stratified medicine to treat tumors that have compromised signaling through TSC and are inflexible in their capacity to restore ER homeostasis.
Correspondence: An appraisal of the effects on human health and the environment of using light-emitting diodes (2019)

International audience
Transition from Coulomb blockade to insulator regime in multiwall carbon nanotubes (2006)

Abstract An experimental study of electronic transport at very low temperature of multiwall carbon nanotubes is presented. We observed two manifestations of a transition from a Coulomb blockade regime to an insulator regime. The first one is on the temperature dependence of the sample resistance, changing from a power law regime to an activated law at a transition temperature T C . The second one manifests itself below T C in the d V /d I ( V ) profile: at a threshold voltage V C the resistance changes abruptly from an insulating state to a Coulomb blockade regime characterized by a power law dependence on the voltage. Influence of disorder on Coulomb blockade regime is also enlightened. (© 2006 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Impact of Intrinsic Capacitances on the Dynamic Performance of Printed Electrolyte-Gated Inorganic Field Effect Transistors (2019)

Electrolyte-gated, printed field-effect transistors exhibit high charge carrier densities in the channel and thus high on-currents at low operating voltages, allowing for the low-power operation of such devices. This behavior is due to the high area-specific capacitance of the device, in which the electrolyte takes the role of the dielectric layer of classical architectures. In this paper, we investigate intrinsic double-layer capacitances of ink-jet printed electrolyte-gated inorganic field-effect transistors in both in-plane and top-gate architectures by means of voltage-dependent impedance spectroscopy. By comparison with deembedding structures, we separate the intrinsic properties of the double-layer capacitance at the transistor channel from parasitic effects and deduce accurate estimates for the double-layer capacitance based on an equivalent circuit fitting. Based on these results, we have performed simulations of the electrolyte cutoff frequency as a function of electrolyte and gate resistances, showing that the top-gate architecture has the potential to reach the kilohertz regime with proper optimization of materials and printing process. Our findings additionally enable accurate modeling of the frequency-dependent capacitance of electrolyte/ion gel-gated devices as required in the small-signal analysis in the circuit simulation.
Interfacial Properties of Fluorocarbon and Hydrocarbon Phosphate Surfactants at the Water−CO2 Interface (2005)

With high-pressure pendant-drop tensiometry, the interfacial tension (γ) and surface excess (Γ∞) for a family of ionic surfactants with identical phosphate headgroups and varying fluorocarbon and hydrocarbon tail structures were examined at the water−CO2 interface. To compensate for the unusually weak CO2−surfactant tail interactions, we designed hydrocarbon tails with weak tail−tail interactions to achieve a more favorable hydrophilic−CO2-philic balance. Branching of hydrocarbon surfactant tails is shown to lead to more favorable adsorption at the interface, closer to that of fluorocarbon surfactants. γ for a double-tail hydrocarbon phosphate surfactant with a relatively high degree of tail branching was lowered from the water−CO2 binary interface value of about 20 mN/m at 25 °C and 340 bar to 3.7 mN/m. This reduction in γ is attributed to both a decrease in the free volume between tails at the interface and reduced tail−tail interactions. In addition to tail structure, the effects of surfactant counterion, salt concentration, temperature, and CO2 density on γ and Γ∞ were investigated. The hydrophilic−CO2-philic balances of these surfactants are mapped by investigating changes in interfacial tension with these formulation variables. Low-molecular-weight branched hydrocarbon ionic surfactants are shown to stabilize concentrated CO2-in-water emulsions for greater than 1 h.
Ganglion cell choristoma of the deep branch of the radial nerve: report of a singular case (2013)

Ganglion cell-containing tumours of the central nervous system (CNS) include gangliogliomas and gangliocytomas which are among the least common tumours of the CNS.1–3 Ganglion cell-containing tumours of the pituitary gland are extremely rare, and consist of well-differentiated mature ganglion cells within a neuropil-rich background.4–6 There have also been two reported cases of ganglion cell-containing cutaneous tumours, reported as ‘cutaneous ganglion cell choristoma’ 7 and ‘ganglioneuromatous tumour of the skin’.8 Ganglion cells are not normal components of the peripheral nerve, and ganglion cell-containing tumours of the peripheral nerve have not been previously described. We report a ganglion cell-containing benign tumour, corresponding to ganglion cell choristoma, in the peripheral nerve in a 52-year-old man who presented with a deep radial neuropathy.

A 52-year-old, right-handed man was evaluated at our institution for left hand weakness of 3 months duration. He first noticed inability to extend his left index finger after waking up from sleep. Subsequently, he noticed weakness in extending all his fingers, and tightness in them. The hand weakness was severe enough to cause functional impairment. There was no associated pain or paresthesias, and no history of preceding trauma. His past medical history was unremarkable.

Neurological examination revealed atrophy of the extensor compartment of the left forearm. Severe weakness of finger extension (Figure 1A), and mild wrist extension and supination was noted on the left side. He had preserved elbow flexion from biceps and brachioradialis muscles. No sensory deficit was noted on clinical evaluation. Deep tendon reflexes, including the left triceps jerk, were preserved. The remainder of the neurological examination was normal. A mass lesion could not …