gebhart/patrepeval huggingface dataset:
Bioactivity in an Aggrecan 32‐mer Fragment Is Mediated via Toll‐like Receptor 2 (2015)

The aggrecan 32-mer fragment is a novel endogenous ligand of TLR-2 with the potential to accelerate cartilage destruction in vivo.
Role of buried oxide microstructure in dosimetry of implanted oxygen in SIMOX technology (2003)

In this paper, we present and discuss the role of the microstructure of the buried oxide of standard dose SIMOX in controlling of the accuracy and reproducibility of the implanted oxygen dose in SIMOX technology. Specific effects of implant process conditions on the buried oxide microstructure are shown. The discussion is supported by the data from large number of processes. Implications for low dose SIMOX manufacture are addressed.
High Performance Soft Magnetic Composite (SMC) Produced by Improved Process (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Gyrophone: recognizing speech from gyroscope signals (2014)

We show that the MEMS gyroscopes found on mod-ern smart phones are sufficiently sensitive to measure acoustic signals in the vicinity of the phone. The re-sulting signals contain only very low-frequency infor-mation (&amp;lt;200Hz). Nevertheless we show, using signal processing and machine learning, that this information is sufficient to identify speaker information and even parse speech. Since iOS and Android require no special per-missions to access the gyro, our results show that apps and active web content that cannot access the micro-phone can nevertheless eavesdrop on speech in the vicin-ity of the phone. 1
Selective Attention to Specific Location Cues: The Peak and Center of a Patch are Equally Accessible as Location Cues (1998)

Asymmetric patterns have several spatially distinct cues for spatial localization. These cues include the peak of the luminance distribution, the centroid of the contrast distribution, zero-crossings in the second derivative of the luminance profile, and the midpoint of the visible area. If these cues are represented as primitives in the visual system, the observer should be able to access them at will. To examine whether observers can selectively attend to particular cues, we measured perceived alignment for an asymmetric pattern with two distinct instructions: "align the peak", and "align the center". We found that observers could align the patterns in accord with the instructions with identical precision, suggesting that the peak and the center cues were equally accessible by the observer. We conclude that multiple localization cues are represented in and can be selectively accessed by the visual system.
Characteristics and Outcomes of Ventricular Tachycardia and Premature Ventricular Contractions Ablation in Patients with Prior Mitral Valve Surgery (2021)

Background: Data regarding ventricular tachycardia (VT) or premature ventricular complex (PVC) ablation following MVS is limited.) CA can be challenging given perivalvular substrate in the setting of mitral annuloplasty or prosthetic valves. Objective: To investigate the characteristics, safety, and outcomes of radiofrequency catheter ablation (CA) in patients with prior mitral valve surgery (MVS) and ventricular arrhythmias (VA). Methods: We identified consecutive patients with prior MVS who underwent CA for VT or PVC between January 2013- December 2018. We investigated the mechanism of arrhythmia, ablation approach, peri-operative complications, and outcomes. Results: In our cohort of 31 patients (77% men, mean age 62.3±10.8 years, left ventricular ejection fraction 39.2±13.9%) with prior MVS underwent CA (16 VT; 15 PVC). Access to the left ventricle was via transseptal approach in 17 patients, and a retrograde aortic approach was used in 13 patients. A combined transseptal and retrograde aortic approach was used in one patient, and a percutaneous epicardial approach was combined with trans-septal approach in 1patient. Heterogenous scar regions were present in 94% of VT patients and scar-related reentry was the dominant mechanism of VT. Clinical VA substrates involved the peri-mitral area in 6 patients with VT and 5 patients with PVC ablation. No procedure-related complications were reported. The overall recurrence-free rate at 1-year was 72.2%; 67% in the VT group and 78% in the PVC group. No arrhythmia-related death was documented on long-term follow-up. Conclusion: CA of VAs can be performed safely and effectively in patients with MVS
MRI of the corpus callosum in multiple sclerosis: association with disability (2010)

Inflammatory demyelination and axon damage in the corpus callosum are prominent features of multiple sclerosis (MS) and may partially account for impaired performance on complex tasks. The objective of this article was to characterize quantitative callosal MRI abnormalities and their association with disability. In 69 participants with MS and 29 healthy volunteers, lesional and extralesional callosal MRI indices were estimated via diffusion tensor tractography. expanded disability status scale (EDSS) and MS functional composite (MSFC) scores were recorded in 53 of the participants with MS. All tested callosal MRI indices were diffusely abnormal in MS. EDSS score was correlated only with age (r = 0.51). Scores on the overall MSFC and its paced serial auditory addition test (PASAT) and 9-hole peg test components were correlated with callosal fractional anisotropy (r = 0.27, 0.35, and 0.31, respectively) and perpendicular diffusivity (r = -0.29, -0.30, and -0.31) but not with overall callosal volume or callosal lesion volume; the PASAT score was more weakly correlated with callosal magnetization-transfer ratio (r = 0.21). Anterior callosal abnormalities were associated with impaired PASAT performance and posterior abnormalities with slow performance on the 9-hole peg test. In conclusion, abnormalities in the corpus callosum can be assessed with quantitative MRI and are associated with cognitive and complex upper-extremity dysfunction in MS.
2066. Accelerated Detection of Carbapenem Resistance Mechanisms in Enterobacteriaceae by MALDI-TOF Mass Spectrometry Using the Direct-on-Target Microdroplet Growth Assay (DOT-MGA) (2018)

The differential identification of carbapenemases relies mostly on molecular techniques. Current phenotypic methods require 18 hours of incubation. We propose a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)-based direct-on-target microdroplet growth assay (DOT-MGA) aiming to offer an easy and rapid phenotypic identification of AmpC, KPC, MBL and OXA production. Seven well-characterized Enterobacteriaceae strains recommended by EUCAST for carbapenemase detection were analyzed. Synergy between meropenem and carbapenemase inhibitors (phenylboronic acid, aminophenylboronic acid, cloxacillin, dipicolinic acid, ethylenediaminetetraacetic acid, and avibactam) and temocillin resistance were determined using a testing panel developed on a 96-spot MALDI-TOF MS target (MBT Biotarget 96, Bruker Daltonics, Germany). Microdroplets (6 µl) containing bacterial suspension and antibiotic or antibiotic/inhibitor in cation-adjusted Mueller–Hinton broth were spotted on the target and incubated for 4 hours at 36°C in a humidity chamber to avoid evaporation. The medium was subsequently removed and MALDI-TOF MS of the cells adhered to the target’s surface was performed. The minimum inhibitory concentration (MIC) was considered to be the lowest concentration at which the MALDI Biotyper software yielded no organism identification. Synergy was defined by an eightfold or greater reduction of the meropenem MIC in the presence of an inhibitor. The absence of synergy between meropenem and inhibitors as well as high-level temocillin resistance was considered suggestive of OXA production. Results were processed and interpreted with a computer-based algorithm. After 4 hours, the method was able to correctly detect the foreknown resistance mechanisms of all tested strains (KPC, MBL, OXA, and AmpC), yielding results that agreed with those obtained by performing broth microdilution with 18 hours of incubation. The DOT-MGA approach allowed easy identification and differentiation of carbapenemase production, delivering reliable results one day earlier than the usual phenotypic methods, thus displaying great potential for the clinical setting. E. A. Idelevich, Bruker Daltonik: Co-inventor of a pending patent, Licensing agreement or royalty and Speaker honorarium. K. Sparbier, Bruker Daltonik: Employee, Salary. M. Kostrzewa, Bruker Daltonik: Employee, Salary. K. Becker, Bruker Daltonik: Co-inventor of a pending patent, Licensing agreement or royalty and Speaker honorarium.
Integrated RF Passive Filtering Circuits in Organic Package Substrate (2007)

Integration of RF passive components like filter, diplexer and matching network on organic substrate are discussed in this paper. These passives are composed of a few lumped elements, mainly inductors and capacitors, which are realized using wind traces or parallel plate with high-k dielectric material sandwiched between them. A few test samples have been fabricated on a multi-layer organic substrate. Measurement results based on two-port VNA have been compared with HFSS simulation results. Good agreement has been observed except that measurement shows more loss in the pass band than the simulation prediction.
Catalytic performance of the biosynthesized AgNps from Bistorta amplexicaule : antifungal, bactericidal, and reduction of carcinogenic 4-nitrophenol (2020)

Abstract This study was focused to synthesize silver nanoparticles (AgNps) from the aqueous extract of Bistorta amplexicaule and to evaluate their antimicrobial, antifungal, and 4-nitrophenol (4-NP) degradation potential. The AgNps from B. amplexicaule were characterized by field emission scanning electron microscopy, energy dispersive X-ray spectrometry, X-ray diffraction, and X-ray photoelectron spectroscopy studies. The biological activity of the AgNps was checked against the three bacterial and two fungal strains. The inhibition activities of the synthesized nanoparticles on pathogenic bacteria and fungi were equally studied using the colony-forming unit method. The AgNps synthesized showed excellent bactericidal and fungicidal activities against pathogenic Escherichia coli , Staphylococcus aureus , methicillin-resistant Staphylococcus aureus (MRSA), Candida albicans , and Candida tropicalis . The removal of nitrophenols is one of the most demanding tasks, due to their injurious impact on the health of the living organisms. The AgNps showed superior performance compared with the pure plant extract. The AgNps also displayed efficient catalytic ability in reducing toxic 4-NP into harmless 4-aminophenol in the presence of NaBH 4 solution. Hence, the synthesized AgNps can be effectively used against bacterial and fungal infections and in the decontamination of 4-NP polluted water.
Recombinant Microbial ADP-Ribosylating Toxins of Bordetella pertussis, Vibiro choierae, and Enterotoxigenic Escherichia coli: Structure, Function, and Toxoid Vaccine Development (2020)

The principal pathological effects produced by several bacterial species are mediated by a class of secreted enzyme toxins, termed ADP-ribosyltransferases. The enzymatic toxins of Bordetella pertussis, Vibrio choierae, and enterotoxigenic Escherichia coli exert their action by covalent modification of the a-subunit of heterotrimeric guanyl nucleotide-binding proteins (G proteins) involved in the transduction of certain receptor-coupled agonist regulatory signals that modulate control of intracellular adenylate cyclase. Cholera toxin and the heat-labile enterotoxins of E. coli are, respectively, the direct cause of the diarrhea and vomiting resulting from infection with V. choierae and enterotoxigenic E. coli. Cholera toxin and the LTs share a common oligomeric structure, consisting of an A protomer and B oligomer. Each of these three ADP-ribosylating toxins conform to an A-B structural organization: an active (A) subunit possessing catalytic potential and a binding (B) subunit involved in cellular recognition.
Dual Affinity to RBCs and Target Cells (DART) Enhances Both Organ- and Cell Type-Targeting of Intravascular Nanocarriers (2022)

A long-standing goal of nanomedicine is to improve a drug's benefit by loading it into a nanocarrier that homes solely to a specific target cell and organ. Unfortunately, nanocarriers usually end up with only a small percentage of the injected dose (% ID) in the target organ, due largely to clearance by the liver and spleen. Further, cell-type-specific targeting is rarely achieved without reducing target organ accumulation. To solve these problems, we introduce DART (<i>d</i>ual <i>a</i>ffinity to <i>R</i>BCs and <i>t</i>arget cells), in which nanocarriers are conjugated to two affinity ligands, one binding red blood cells and one binding a target cell (here, pulmonary endothelial cells). DART nanocarriers first bind red blood cells and then transfer to the target organ's endothelial cells as the bound red blood cells squeeze through capillaries. We show that within minutes after intravascular injection in mice nearly 70% ID of DART nanocarriers accumulate in the target organ (lungs), more than doubling the % ID ceiling achieved by a multitude of prior technologies, finally achieving a majority % ID in a target organ. Humanized DART nanocarriers in <i>ex vivo</i> perfused human lungs recapitulate this phenomenon. Furthermore, DART enhances the selectivity of delivery to target endothelial cells over local phagocytes within the target organ by 6-fold. DART's marked improvement in both organ- and cell-type targeting may thus be helpful in localizing drugs for a multitude of medical applications.
Transcriptional control of the main aromatic hydrocarbon efflux pump in Pseudomonas (2011)

Bacteria of the species Pseudomonas putida are ubiquitous soil inhabitants, and a few strains are able to thrive in the presence of extremely high concentrations of toxic solvents such as toluene and related aromatic hydrocarbons. Toluene tolerance is multifactorial in the sense that bacteria use a wide range of physiological and genetic changes to overcome solvent damage. This includes enhanced membrane impermeabilization through cis to trans isomerization of unsaturated fatty acids, activation of a stress response programme, and induction of efflux pumps that expulse toxic hydrocarbons to the outer medium. The most relevant element in this toluene tolerance arsenal is the TtgGHI efflux pump controlled by the TtgV regulator. We discuss here how TtgV controls expression of this efflux pump in response to solvents.
Architectural perspectives of future wireless base stations based on the IBM PowerEN&#x2122; processor (2012)

In wireless networks, base stations are responsible for operating on large amounts of traffic at high speed rates. With the advent of new standards, as 4G, further pressure is put in the hardware requirements to satisfy speeds of up to 1 Gbps. In this work, we study the applicability and potential benefits of the IBM PowerEN processor (a multi-core, massively multithreaded platform) in the realm of base stations for the 3G and 4G standards. The approach involves exploiting the throughput computation capabilities of the PowerEN processor, replacing the bus-attached special-function accelerators with a layer of in-line universal acceleration support, incorporated within the cores. A key feature of this in-line accelerator is a bank-based very-large register file, with embedded SIMD support. This processor-in-regfile (PIR) strategy is implemented as local computation elements (LCEs) attached to each bank, overcoming the limited number of register file ports. Because each LCE is a SIMD computation element, and all of them can proceed concurrently, the PIR approach constitutes a highly-parallel super-wide-SIMD device. To target a broad spectrum of applications for base stations, we also consider a PIR-based architecture built upon reconfigurable LCEs. In this paper, we evaluate the in-line universal accelerator and the PIR strategy focusing on two specific applications for base stations: FFT and Turbo Decoding.
Efficient and private approximations of distributed databases calculations (2017)

In recent years, an increasing amount of data is collected in different and often, not cooperative, databases. The problem of privacy-preserving, distributed calculations over separate databases and, a relative to it, the issue of private data release were intensively investigated. However, despite a considerable progress, computational complexity, due to an increasing size of data, remains a limiting factor in real-world deployments, especially in case of privacy-preserving computations. In this paper, we suggest sampling as a method of improving computational performance. Sampling was a topic of extensive research that recently received a boost of interest. We provide a sampling method targeted at separate, non-collaborating, vertically partitioned datasets. The method is exemplified and tested on approximation of intersection set both without and with privacy-preserving mechanism. An analysis of the bound on error as a function of the sample size is discussed and heuristic algorithm is suggested to further improve the performance. The algorithms were implemented and experimental results confirm the validity of the approach.
Generalized Optical Flow based Motion Vector Refinement in AV1 (2021)

Bi-directional optical flow (BDOF) is a coding tool that has been recently adopted into Versatile Video Coding (VVC) standard. In BDOF, gradients of prediction samples are exploited to refine motion vector (MV) per subblock within a prediction block, and thus enhance inter prediction quality in a two-pass framework. In this work, we extend the concept of BDOF to a more general compound prediction framework and integrated this framework into the AV1 codec. In particular, we support MV refinement not only in bi-directional compound prediction, but also in uni-directional prediction, where the two reference blocks are both from the past or both from the future. Furthermore, two reference blocks are allowed to have arbitrary temporal distances to the current block. For implementation on the AV1 codec, five additional inter compound modes have been added, and the proposed method is performed on top of those modes. Experimental results show more than 2.8% BD rate saving on the Google test set.
Carton Set Optimization in E‐commerce Warehouses: A Case Study (2020)

In this study, a three‐stage methodology for carton set optimization in e‐commerce warehouses is proposed and evaluated on three DHL Supply Chain warehouses. The methodology includes order cubing, carton grouping, and optimal carton set selection. A modified largest area fits first algorithm for order cubing is proposed. For optimal carton set selection, a genetic algorithm with a novel crossover strategy is introduced. The results show that the proposed carton set optimization approach can improve the shipping cost and carton utilization by 7% and 7.8%, and considerably improve the carbon footprint of the operations, even when the number of carton types is not changed.
Squamous cell carcinoma of the oral cavity and the oropharynx in patients less than 40 years of age: a 20-year analysis (2012)

The results from the present study showed that young adults may have a better prognosis especially in terms of long term overall survival from oral and oropharyngeal carcinoma.
Comparison of the tolerance of hepatic ischemia/reperfusion injury in living donors: Macrosteatosis versus microsteatosis (2014)

A safe use of intermittent hepatic inflow occlusion (IHIO) has been reported for living donor hepatectomy. However, it remains unclear whether the maneuver is safe in steatotic donors. In addition, the respective importance of macrosteatosis (MaS) and microsteatosis (MiS) is an important issue. Thus, we compared MiS and MaS with respect to the tolerance of hepatic ischemia/reperfusion (IR) injury induced by IHIO. One hundred forty-four donors who underwent a right hepatectomy were grouped according to the presence of MaS and MiS: a non-MaS group (n = 68) versus an MaS group (n = 76) and a non-MiS group (n = 51) versus an MiS group (n = 93). The coefficients of the regression lines between the cumulative IHIO time and the peak postoperative transaminase concentrations were used as surrogate parameters indicating the tolerance of hepatic IR injury. The coefficients were significantly greater for the MaS group versus the non-MaS group (4.12 ± 0.59 versus 2.22 ± 0.46 for alanine aminotransferase, P = 0.01). Conversely, the MiS and non-MiS groups were comparable. A subgroup analysis of donors who underwent IHIO for >30 minutes showed that MaS significantly increased the transaminase concentrations, whereas MiS had no impact. Also, IHIO for >30 minutes significantly increased the biliary complication rate for MaS donors (12.1% for ≤ 30 minutes versus 32.6% for >30 minutes, P = 0.04), whereas MiS donors were not affected. In conclusion, the tolerance of hepatic IR injury might differ between MaS livers and MiS livers. It would be rational to assign more clinical importance to MaS versus MiS. We further recommend limiting the cumulative IHIO time to 30 minutes or less for MaS donors undergoing right hepatectomy.
Submillimeter-wave InP HEMT amplifiers with current-reuse topology (2013)

This paper describes the use of InP HEMT technology to develop submillimeter-wave amplifier circuits. The amplifiers are designed using common-gate amplifiers with series inductors, which achieve both high gain and wide bandwidth. Two submillimeter-wave amplifiers are designed. One is a D-band amplifier that achieves a small-signal gain of 15 dB at 160 GHz and a -3 dB bandwidth of 89 GHz between 105 and 194 GHz. The other is a G-band amplifier that achieves a small signal gain of 10 dB at 200 GHz and a -3 dB bandwidth of 80 GHz between 130 and more than 220 GHz. These results demonstrate the design methodology is one of the best candidates for developing submillimeter-wave amplifiers.
Nm-scale measurements of fast surface potential transients in an AlGaN/GaN high electron mobility transistor (2012)

Fast, bias-induced, surface potential transients (SPTs) and conductance transients (CTs) were simultaneously measured on an AlGaN/GaN high electron mobility transistor. SPTs measured near the drain-side gate edge and CTs have nearly the same shape and are well-fit with two exponentials having room-temperature time constants of 4.2 ms and 36 ms, likely indicating emission from two trap species. Kelvin probe force microscopy was used to measure SPTs. Electrostatic simulations of SPT amplitudes, which account for the measured probe/sample geometry, are consistent with a uniform trapped surface charge density of 7 × 1012 electrons/cm2 extending 200 nm from the drain-side gate edge.
ChemInform Abstract: New Unnatural L‐Nucleoside Enantiomers: From Their Stereospecific Synthesis to Their Biological Activities. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.