gebhart/patrepeval huggingface dataset:
Efficacy and safety of dupilumab in Japanese adults with moderate‐to‐severe atopic dermatitis: a subanalysis of three clinical trials (2019)

Dupilumab alone or with topical corticosteroids improved signs and symptoms of AD, had an acceptable safety profile, and suppressed biomarkers of type 2 inflammation compared with placebo in Japanese adult patients with moderate-to-severe AD. What's already known about this topic? Differences in atopic dermatitis (AD) pathology have been reported between Asian and Western populations, in which distinct helper T-cell activation profiles have been observed. International clinical studies in adults with moderate-to-severe AD have evaluated the efficacy and safety of dupilumab, which blocks interleukin-4 and interleukin-13, key molecules in type 2 inflammation. The effects of dupilumab in Japanese patients specifically have not yet been reported. What does this study add? Dupilumab alone or with topical corticosteroids improved signs and symptoms of AD and had an acceptable safety profile compared with placebo in Japanese patients with moderate-to-severe AD. The effects were comparable with those observed in the overall study population. Reported immunological differences in AD pathology in Asian patients may be secondary to type 2 immune activation.
Novel 190V LIGBT-based ESD protection for 0.35μm Smart Power technology realized on SOI substrate (2008)

A novel ESD protection implementation based on LIGBT component is presented for 0.35 mum Smart Power HV devices on SOI substrate. A Single Stage LIGBT was designed, characterized and simulated. SOA boundaries are investigated in TLP regime. ESD performances improvements achieved using LIGBT devices are highlighted and a comparison with NDRIFTMOS-based active clamps is presented.
ChemInform Abstract: Photosensitive Chemically Modified Electrodes for Photogalvanic Cells (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Abstract 4270: NGS based microhaplotype counting for ultrasensitive human DNA detection (2015)

Abstract Introduction: Fields of forensics, paternity, and hematopoietic stem cell transplantation (HSCT) require human identity testing. The polymorphic nature of short tandem repeats (STRs) makes them most frequently used but they are relatively insensitive. In 2000, we demonstrated proof-of-principle for the use of SNPs for bone marrow engraftment testing; however, due to the high error rate of NGS platforms, use of a single SNP for this purpose is not possible. Here, we hypothesized that using multiple SNPs on a short amplicon (microhaplotype) could overcome the inherently high error rate of NGS, and use it for ultrasensitive detection of human DNA mixes. Methods: As proof-of-principle, we identified a 119 bp region on HLA-A Exon 3 that contains a cluster of 18 SNPs. Using cell lines with known HLA-A haplotypes, we made serial dilutions from 1% to 0.001%. By sequencing each dilution at least twice we were able to determine accuracy and limit of detection. Samples collected from patients after BMT that tested as all donor were analyzed using this approach. Sample preparation and sequencing was done per manufacturer's protocol using the Ion Torrent Personal Genome Machine and 200 base chemistry. Additionally, we analyzed the 1000 Genomes database, using 300 bp windows, and identified many other loci that contained clusters of at least 9 SNPs. Results: Alignment and analysis of common European HLA-A haplotypes of this region show mean number of differences of ∼6 SNPs. Homozygous samples with known HLA-A genotypes that varied by multiple SNPs were analyzed and demonstrated no cross-talk between them. Analyzing serially diluted samples we were able to easily achieve a limit of detection of 1 in 10,000 molecules (0.01%). In BMT samples that tested as all donor by STR analysis, we were able to detect patient DNA of up to 1.5%. From 1000 Genomes data, we identified 4,349 loci that contained at least 9 SNPs within a 300 bp window. Informativity of identified loci was determined for 3 major ethnic groups using 1000 Genomes phased haplotype data. Conclusions: Ultrasensitive detection of human DNA mixes can be achieved using multiple SNPs within a short amplicon despite the high error rates associated with NGS. This assay may be useful to detect early relapse following bone marrow transplantation and other clinical applications. Citation Format: Marija Debeljak, Donald N. Freed, Jane A. Welch, Lisa Haley, Katie Beierl, Brian S. Iglehart, Aparna Pallavajjala, Christopher D. Gocke, Mary S. Leffell, Ming-Tseh Lin, Laura D. Wood, Jonathan Pevsner, Sarah J. Wheelan, James R. Eshleman. NGS based microhaplotype counting for ultrasensitive human DNA detection. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4270. doi:10.1158/1538-7445.AM2015-4270
Crowdsourced Exploration of Security Configurations (2015)

Smartphone apps today request permission to access a multitude of sensitive resources, which users must accept completely during installation (e.g., on Android) or selectively configure after installation (e.g., on iOS, but also planned for Android). Everyday users, however, do not have the ability to make informed decisions about which permissions are essential for their usage. For enhanced privacy, we seek to leverage crowdsourcing to find minimal sets of permissions that will preserve the usability of the app for diverse users. We advocate an efficient 'lattice-based' crowd-management strategy to explore the space of permissions sets. We conducted a user study (N = 26) in which participants explored different permission sets for the popular Instagram app. This study validates our efficient crowd management strategy and shows that usability scores for diverse users can be predicted accurately, enabling suitable recommendations.
A Method for Improving Component Decoupling Using Advanced Capacitor Under Ball Grid Array (ACUB) (2003)

Industry demands on power delivery continue to increase with higher performance silicon products. As a result, higher current sustainability and better transient response are key parameters frequently sought in successful power delivery designs. One key design feature for improved transient response involves locating decoupling capacitance as close to the load as possible. At the board level, this is typically accomplished by placing capacitors around the immediate vicinity of the load. With a set of identical capacitors in parallel, total capacitance is essentially a multiple of the number of caps while the effective series resistance and inductance is divided. However the realities of package and motherboard design can often limit the number and size of the capacitors placed in the vicinity of the load. In some cases, the capacitors may interfere with other routings to and from the component. In other cases, placement of the capacitors with respect to the DC current path may limit their effectiveness by inducing a large effective series inductance to the load. This paper describes a potential design method for maximizing capacitor effectiveness while minimizing its impact on other board features. The design is primarily implemented in board assembly and involves placing capacitors directly between power and ground board-component solder joints. As an extension of Capacitor Under BGA designs, this method is termed Advanced Capacitor Under BGA (ACUB). Using ACUB can improve load decoupling, but can require new approaches to board and component assembly. This paper discusses a number of potential design improvements allowed for using this design approach. In addition, factors involved in successful assembly are discussed and sets of proof-of-concept prototype designs are presented along with assembly results. From this, some designs with potential for further development are identified and next steps discussed.
Combination wt-p53 and MicroRNA-125b Transfection in a Genetically Engineered Lung Cancer Model Using Dual CD44/EGFR-targeting Nanoparticles (2015)

Mutations in KRAS and p53 signaling pathways contribute to loss of responsiveness to current therapies and a decreased survival in lung cancer. In this study, we have investigated the delivery and transfection of wild-type (wt-) p53 and microRNA-125b (miR-125b) expressing plasmid DNA, in SK-LU-1 human lung adenocarcinoma cells as well as in Kras(G12D)/p53(fl/fl) (KP) genetically engineered mouse model of lung cancer. Systemic plasmid DNA delivery with dual CD44/EGFR-targeted hyaluronic acid (HA)-based nanoparticles (NPs) resulted in a 2- to 20-fold increase in wt-p53 and miR-125b gene expression in SK-LU-1 cells. This resulted in enhanced apoptotic activity as seen with increased APAF-1 and caspase-3 gene expression. Similarly, in vivo evaluations in KP mouse model indicated successful CD44/EGFR-targeted delivery. Tumor growth inhibition and apoptotic induction were also observed with (wt-p53+miR125b) combination therapy in KP tumor model. Lastly, J774.A1 murine macrophages co-cultured with transfected SK-LU-1 cells showed a 14- to 35-fold increase in the iNOS-Arg-1 ratio, supportive of previous results demonstrating a role of miR-125b in macrophage repolarization. Overall, these results show tremendous promise of wt-p53 and miR-125b gene therapy using dual CD44/EGFR-targeting HA NP vector for effective treatment of lung cancer.
Synthetic Control of Pt···Pt Separation and Photophysics of Binuclear Platinum Complexes (2004)

A new series of luminescent mu-pyrazolate-bridged cyclometalated platinum binuclear complexes having the formula CwedgeNPt(mu-pz')2PtCwedgeN (CwedgeN = 2-(2,4-difluorophenyl)pyridyl, pz' = pyrazolate for 1, 3,5-dimethylpyrazolate for 2, 3-methyl-5-tert-butylpyrazolate for 3, and 3,5-bis(tert-butyl)pyrazolate for 4) have been synthesized and characterized. The two Pt(CwedgeN) moieties are bridged by two mu-pyrazolate ligands in an exo-bidentate fashion. A mononuclear complex with an isolated Pt center, CwedgeNPt(pz)2BEt2, 5, is also described. The X-ray crystal structures of 1-4 show the following Pt-Pt spacings: 1 = 3.3763(7) A, 2 = 3.1914(9) A, 3 = 3.0457(7) A, and 4 = 2.8343(6) A. At 77 K, the emission energy of the complexes varies from blue (for 1, 2, and 5) to green (for 3) to red (for 4). The changes in the photophysical properties of the binuclear complexes can be correlated with the decreasing Pt-Pt distance; the emissive state changes from a mixed ligand center triplet/metal-to-ligand charge transfer excited state (for 1 and 2) to a lower-energy, Pt-Pt metal-metal-to-ligand charge transfer state (for 3 and 4).
Mesoporous Materials For Sorption of Actinides (2012)

This chapter contains sections titled: Introduction Experimental Results and Discussion Conclusions Acknowledgement
Analytical Discharge Model for RF Ion Thrusters (2008)

A comprehensive 0-D model of the plasma discharge in magnetic ring-cusp ion thrusters was previously developed. The model utilizes conservation of particles into and out of the ion thruster and conservation of energy into the discharge and out of the plasma, and provided the first closed solution for predicting ion-thruster discharge chamber performance. The 0-D discharge model was benchmarked against the performance measured on several ion thrusters, and successfully predicts the discharge loss as a function of mass utilization efficiency. The analytical model has been modified to handle the discharge chamber configurations and the different magnetic confinement physics found in RF ion thrusters. In these ion thrusters, there is no applied magnetic field to provide confinement of the electrons and ions, but the ac magnetic field induced by the inductively coupled RF coil affects the particle confinement and transport and is important in determining the discharge loss and thruster performance. The modifications to the model required to address the physics of RF thrusters will be discussed, and results showing the predicted ion thruster performance will be presented.
Design of current controller for 3-phase PWM converter with unbalanced input voltage (2002)

Generally current controllers of three-phase PWM power converters have been implemented in the synchronous frame because the synchronous frame controller can eliminate steady state error and has fast transient response by decoupling control. However most of such controllers have been designed under balanced input voltage. Therefore such designed current controllers showed undesirable current control characteristics under unbalanced conditions because the current reference is distorted by the second order harmonic voltage due to negative sequence. In this paper, a current controller for a PWM power converter, considering unbalanced input voltage, is designed and verified by both simulation and experiment.
Intravitreal Sirolimus for Noninfectious Uveitis: A Phase III Sirolimus Study Assessing Double-masKed Uveitis TReAtment (SAKURA) (2016)

Intravitreal sirolimus 440 μg demonstrated a significant improvement in ocular inflammation with preservation of BCVA in subjects with active NIU of the posterior segment.
The Autonomous Transactivation Domain in Helix H3 of the Vitamin D Receptor Is Required For Transactivation and Coactivator Interaction (1999)

A ligand-inducible transactivation function (AF-2) exists in the extreme carboxyl terminus of the vitamin D receptor (VDR) that is essential for 1alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3)-activated transcription and p160 coactivator interaction. Crystallographic data of related nuclear receptors suggest that binding of 1, 25-(OH)2D3 by VDR induces conformational changes in the ligand-binding domain (LBD), the most striking of which is a packing of the AF-2 helix onto the LBD adjacent to helices H3 and H4. In this study, a panel of VDR helix H3 mutants was generated, and residues in helix H3 that are important for ligand-activated transcription by the full-length VDR were identified. In particular, one mutant (VDR (Y236A)) exhibited normal ligand binding and heterodimerization with the retinoid X receptor (RXR) but was transcriptionally inactive. Yeast two-hybrid studies and in vitro protein interaction assays demonstrated that VDR (Y236A) was selectively impaired in interaction with AF-2-interacting coactivator proteins such as SRC-1 and GRIP-1. These data indicate an importance of helix H3 in the mechanism of VDR-mediated transcription, and they support the concept that helix H3 functions in concert with the AF-2 domain to form a transactivation surface for binding the p160 class of nuclear receptor coactivators.
ChemInform Abstract: Introduction of Alkynyl Chains on C‐8 of Adenosine Led to Very Selective Antagonists of the A3 Adenosine Receptor. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
External Catheter Immobilization Improves Wound Healing in Micropigs (1989)

Recurrent traumatic damage by mechanical action is a major cause of catheter exit site problems in CAPD patients. The purpose of this study was to determine the efficacy of a new external immobilization device (Immobilizer) on wound healing characteristics at the catheter exit site. Sixteen Tenckhoff catheters were surgically implanted in four Yucatan micropigs (two catheters per flank). Immobilization devices were placed on one catheter on each side of each animal; the other catheter was allowed free movement. The devices were changed daily, and exit sites were examined for wound healing progress and infection. Fourteen days following implantation the animals were sacrificed, and the catheter exit sites explanted for histologic examination. The results of this study suggest that immobilization of catheters with this device improves wound healing at the exit site, as evidenced by decreased (p less than 0.05) marsupialization/epidermal down-growth (nonimmobilized 2.9 mm vs. immobilized 1.6 mm), and an increased (p less than 0.05) macrophage/epithelioid cell/giant cell response within the exit tract or in the Dacron cuff (granulomatous response histology score of 2.3 for immobilized vs. a histology score of 1.6 for nonimmobilized). Thus, use of this device may help reduce catheter exit site problems in CAPD patients.
Quantum Sensing of Absorbance and the Beer-Lambert Law (2019)

Optical quantum sensing strategies that utilise features of quantum states of light have implications for precision measurement in areas as wide ranging as such as gravitational wave sensing [1] and biological imaging [2]. Optical absorption estimation is the task of estimating the transmission parameter η which is defined by the ratio of input, I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in</sub> , to output, I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</sub> , intensity of light from a sample of interest (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</sub> = ηI <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ιη</sub> ). The optimal quantum strategy provides a quantum advantage (per incident photon) of 1/(1-η) over the best classical strategy [3]. This technique has been demonstrated experimentally in single parameter estimation and imaging scenarios [4,5].
Knowledge Management in the Service and Support Business (2000)

As we are entering the New Millenium, we are witnessing a global shift toward a society of services. The evolution of the world&amp;apos;s workforce structure indicates clearly the magnitude and importance of this mega-shift. The introduction of new, exciting technologies has led to a kind of New Economy that is based on the huge and rapid flows of data, information and knowledge. The Internet has had a most profound impact on business and society, enabling the quick spread of service industries and technologies. We observe that cost reduction and acceleration of business processes are the most obvious consequences of this singular phenomenon. In such an environment, the management of IT support services is becoming critical for business profitability. 1
Comparison of the Use of Volume Fractions with other Measures of Concentration for Quantitative Spectroscopic Calibration Using the Classical Least Squares Method (2010)

Since the commercial development of modern near-infrared spectroscopy in the 1970s, analysts have almost invariably used units of weight percent as the measure of analyte concentration, due largely to the historical precedent from other analytical methods, including other spectroscopic techniques. The application of the CLS algorithm to a set of binary and ternary liquid mixtures reveals that the spectroscopic measurement sees the sample differently; that the measured absorbance spectrum is in fact sensitive to the volume fraction of the various components of the mixture. Because there is not a one-to-one relationship between volume fraction and other measures of analyte concentration, nor is the relationship linear, this has important implications for the application of both the CLS algorithm and the various other, more conventional, calibration algorithms that are commonly used.
A Compact Energy Efficient CMOS Permittivity Sensor Based on Multiharmonic Downconversion and Tunable Impedance Bridge (2018)

This paper presents a 0.15×0.3 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> complex permittivity sensor integrated in a 40-nm CMOS node. A single-ended patch, employed as a near-field sensing element, is integrated with a double-balanced, fully-differential tunable impedance bridge that is driven by a square RF pulse. The multi-harmonic, intermediate-frequency down-conversion architecture achieves a compact form factor and fast multi-frequency readout. Measurement results show good agreement with theoretical values and the measured relative permittivity variation remains below 0.3 over a 0.1-10 GHz range at a 1-ms measurement time. The energy efficiency resulting from the fast measurement time and the record-small active area allows integration in battery-operated wearables.
Resonant-Cavity-Enhanced UV Metal–Semiconductor–Metal (MSM) Photodetectors Based on AlGaN System (2001)

Resonant-cavity-enhanced ultraviolet metal-semiconductor-metal photodetectors were successfully fabricated in AlGaN system, for the first time. A 45 nm GaN light absorption layer was placed in the optical cavity composed by the multi-stacked Al 0.06 Ga 0.94 N/AlN (20 pairs) bottom-distributed-Bragg-reflector (DBR) and the ZrO 2 /SiO 2 (two pairs) top-DBR mirrors. In this structure, the enhancement of responsivity can be achieved by incorporating a multiple pass detection scheme. In the experiment, the responsivity was enhanced by the resonant cavity effect, selectively at 363 and 352 nm in wavelength, with a factor of about two, in contrast with the case without the top-DBR.
L'éthique dans tout ses états (2019)

Axel Kahn est medecin geneticien, entre autre ancien directeur de l'INSTITUT COCHIN puis president de l'Universite Paris Descartes. Ses responsabilites a la tete de la Fondation Internationale du Handicap, du Comite d'Ethique de la Ligue du Cancer, du Comite de deontologie du Comite National Olympique et Sportif Francais, ou du Comite d'ethique commun a l'INRA, au CIRAD et a l'IFREMER, lui conferent une legitimite toute particuliere en matiere d'ethique. En 2019, le Parlement est appele a debattre d'un projet de loi sur les questions de bioethique. C'est a debroussailler les grands enjeux de cette echeance majeure, mais aussi a desacraliser un mot aux multiples significations, manifestations, questionnements, que s'emploie ce dialogue. Axel kahn est un scientifique, medecin geneticien et essayiste francais
Hepadnavirus infection of peripheral blood lymphocytes in vivo: woodchuck and chimpanzee models of viral hepatitis (1986)

The peripheral blood lymphocytes (PBL) of five hepatitis B virus (HBV)-infected chimpanzees and 17 woodchuck hepatitis virus (WHV)-infected woodchucks were examined for the presence of viral DNA and RNA. HBV DNA was detected in the PBL of three of three chronically infected chimpanzees but in neither of two animals with acute HBV infection. WHV DNA was found in the PBL of 11 of 13 chronically infected woodchucks and in the PBL and bone marrow of 1 of 4 woodchucks with antibody to WHV surface antigen. Viral DNA in the PBL and bone marrow was episomal, primarily existing as multimers with some monomeric forms. Integrated HBV DNA was detected in the PBL of one chronically infected chimpanzee, but only for a brief period. Viral RNA was also detected in the PBL, although less frequently than was DNA. HBV RNA in chimpanzee PBL existed as 3.8- and 7.5-kilobase species, while 2.3- and 3.8-kilobase WHV RNA was found in woodchuck PBL. Subfractionation of PBL isolated from the chronically infected chimpanzees demonstrated that HBV DNA and RNA were located in B and T cells. No HBV DNA was detected in the macrophages. These results, along with the recent reports of HBV nucleic acids in the PBL of human patients, suggest that infection of PBL may be a general phenomenon associated with the pathology of hepadnaviruses.
ChemInform Abstract: THERMOCHEMICALLY BASED STRATEGIES FOR CARBON‐HYDROGEN ACTIVATION ON SATURATED HYDROCARBON MOLECULES. RING‐OPENING REACTIONS OF A THORACYCLOBUTANE WITH TETRAMETHYLSILANE AND METHANE (1984)

Abstract M2 iumverbindungen Thermochemically Based Strategies for C‐H Activation on Saturated Hydrocarbon Molecules.