gebhart/patrepeval huggingface dataset:
PlasmaMade® filter in Seatrade Reefer containers : effects on banana quality, ethylene and microbial air quality (2016)

Seatrade Reefer Chartering NV from Antwerp (Seatrade), represented by Dale Rolfe (operations manager), indicated that Seatrade is considering to equip all its (new) Reefer containers with an additional air purification system. PlasmaMade, located at Staphorst, Netherlands, has informed Seatrade, that their patented PlasmaMade filter system could be a good system for improved fruit transport conditions, although PlasmaMade has no experience with respect to this specific application. Therefore Seatrade decided that an independent expert view is necessary to support Seatrade in making the right decisions about the potential of this novel and patented filter technology in Reefer container transport. Wageningen UR institute Food & Biobased Research (FBR) was asked to provide independent support on this, with the specific questions:
THE UTILITY OF ONYX FOR PREOPERATIVE EMBOLIZATION OF CRANIAL AND SPINAL TUMORS (2008)

Preoperative embolization of cranial and spinal tumors can be performed safely. Specific technical advantages of Onyx included deep penetration of lesions producing extensive tumor infarction, the ability to embolize extensive portions of the tumors through fewer arterial catheterizations, and the safety of catheter withdrawal despite often substantial reflux along the embolic catheter.
Transient receptor potential vanilloid type 4 channel as a putative target molecule for anti‐hypertensive therapy (1067.10) (2014)

TRPV4 is a non‐selective cation channel causing vasodilatation (Willette et al. 2007) and cerebral arterial re‐modelling in response to shear stress (Schierling et al., 2011). Our hypothesis is that TRPV4 is an intracranial sensor that maintains cerebral blood flow by sympathetically mediated modulation of arterial pressure. Using qPCR, we demonstrated that TRPV4 mRNA levels from common carotid arteries of the Spontaneous Hypertensive Rat (SHR) were lower compared to a normotensive Wistar (9 weeks old animals, p=0.002, n=3). mRNA levels in the SHR brain vasculature were age related with older rats showing higher levels (e.g. at 9 weeks old mRNA was 2 times lower than 13 weeks old SHR, p=0.06, N=3). This difference was not detected in Wistar rats (p=0.997, n=3). We next examined the effect of TRPV4 agonist (GSK1016790A) on arterial pressure in anesthetised SHRs fitted with radio‐telemeters. Bolus intravenous injections showed a dose‐dependent reduction in arterial pressure with maximal response achieved at 166 µg/kg and the lowest effective dose being 42 µg/kg (n=3); the latter dose has been reported to cause circulatory collapse in normotensive rats (Willette et al. 2007). Thus, SHR showed a higher tolerance to the agonist consistent with lower mRNA expression. Presence of TRPV4 in the cerebral vessels and its vasodilatory effect are both consistent with it being an exploitable target for improving cerebral blood flow and for controlling hypertension.
Cyclic dimer of a fused porphyrin zinc complex as a novel host with two π-electronically coupled binding sites (2005)

Upon complexation with 4,4[prime or minute]-bipyridine, a cyclic dimer of a fused porphyrin zinc complex, having two pi-electronically coupled binding sites, shows a strong negative cooperativity in the second guest binding, to allow stepwise formation of 1 : 1 and 1 : 2 inclusion complexes.
Design of Solid-State Circuit Breaker-Based Protection for DC Shipboard Power Systems (2016)

Fast increasing dc fault currents in dc shipboard distribution systems require fast dc protective devices and protection methods. Solid-state circuit breakers (SSCBs) inherently have fast protection speed and thus are proper for dc shipboard distribution protection. Based on the analysis of the fault current features in dc shipboard distribution systems, the design of the system protection employing SSCBs is discussed from the perspectives of SSCB technologies, design requirements, and protection methods. Fast speed, low cost, low loss, and optimized design are major challenges of SSCB-based dc shipboard distribution protection.
Transcript of question and answer session (1978)

chapter Free Access Share on Transcript of question and answer session Author: John Goodenough View Profile Authors Info & Claims History of programming languagesJune 1978 Pages 397–399https://doi.org/10.1145/800025.1198382Published:01 June 1978Publication History 0citation184DownloadsMetricsTotal Citations0Total Downloads184Last 12 Months19Last 6 weeks7 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
A precise model for the transient characteristics of power diodes (2003)

A power diode model for circuit simulations is described. All important phenomena like transient behavior, temperature dependence, emitter recombination, mobile charge carriers in depletion layer, carrier multiplication, and self-heating are included. Comparisons between simulations and measurements show less than 10% deviation of current and voltage over the temperature range of 25 degrees C-125 degrees C.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
3D-ICs created using oblique processing (2016)

This paper demonstrates that another class of three-dimensional integrated circuits (3D-ICs) exists, distinct from through silicon via centric and monolithic 3D-ICs. Furthermore, it is possible to create devices that are 3D at the device level (i.e. with active channels oriented in each of the three coordinate axes), by performing standard CMOS fabrication operations at an angle with respect to the wafer surface into high aspect ratio silicon substrates using membrane projection lithography (MPL). MPL requires only minimal fixturing changes to standard CMOS equipment, and no change to current state-of-the-art lithography. Eliminating the constraint of 2D planar device architecture enables a wide range of new interconnect topologies which could help reduce interconnect resistance/capacitance, and potentially improve performance.
Invasive Thymoma Treated Effectively by Preoperative Chemotherapy and Radiotherapy. (1993)

症例は20才男性. 胸痛を主訴とし近医を受診し縦隔腫瘍の診断で当院に紹介となった. 上大静脈症候群は呈しておらず, 筋無力症状はなかった. HCG・AFP・CEAは正常範囲内.胸部CTでは前縦隔に嚢胞を有する充実性腫瘍を認め, 左腕頭静脈. 右腕頭動脈・左総頚動脈・左鎖骨下動脈は腫瘍により取り囲まれていた. 針生検では確診は得られなかった.CDDP・VP-16による化学療法を2クール行い著明に腫瘍は縮小し, 放射線30Gyの照射で, 腫瘍はさらに縮小した. 胸骨正中切開で開胸し, 心膜・左横隔神経・左腕頭静脈を合併切除し, 腫瘍を摘出した. 動脈系はCUSAの使用により腫瘍内より剥離することができた, 多角形胸腺腫であった. 摘出腫瘍内に細胞成分は乏しく, 壊死巣はないものの広範な線維化を呈しており, 術前治療の著しい効果が認められた. 浸潤型胸腺腫に対する化学療法の有効性が示され, 化学療法を腫瘍の可及的切除に先行して試みる価値があると思われた.
Electrocutaneous Stimulation in a Reading Aid for the Blind (1971)

Electrocutaneous stimulation has been investigated for use in the Optacon, a new reading aid for the blind. Results indicate that electrocutaneous stimulation is not practical as a replacement for tactile stimulation, which is presently being used.
Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA (2021)

Fibrinogen plays a pathologic role in multiple diseases. It contributes to thrombosis and modifies inflammatory and immune responses, supported by studies in mice expressing fibrinogen variants with altered function or with a germline fibrinogen deficiency. However, therapeutic strategies to safely and effectively tailor plasma fibrinogen concentration are lacking. Here, we developed a strategy to tune fibrinogen expression by administering lipid nanoparticle (LNP)-encapsulated small interfering RNA (siRNA) targeting the fibrinogen α chain (siFga). Three distinct LNP-siFga reagents reduced both hepatic Fga messenger RNA and fibrinogen levels in platelets and plasma, with plasma levels decreased to 42%, 16%, and 4% of normal within 1 week of administration. Using the most potent siFga, circulating fibrinogen was controllably decreased to 32%, 14%, and 5% of baseline with 0.5, 1.0, and 2.0 mg/kg doses, respectively. Whole blood from mice treated with siFga formed clots with significantly decreased clot strength ex vivo, but siFga treatment did not compromise hemostasis following saphenous vein puncture or tail transection. In an endotoxemia model, siFga suppressed the acute phase response and decreased plasma fibrinogen, D-dimer, and proinflammatory cytokine levels. In a sterile peritonitis model, siFga restored normal macrophage migration in plasminogen-deficient mice. Finally, treatment of mice with siFga decreased the metastatic potential of tumor cells in a manner comparable to that observed in fibrinogen-deficient mice. The results indicate that siFga causes robust and controllable depletion of fibrinogen and provides the proof-of-concept that this strategy can modulate the pleiotropic effects of fibrinogen in relevant disease models.
CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular Disease (2018)

Experiments using lentivirus vector/CRISPR methodology provided evidence suggesting that inactivating DNMT3A mutations in hematopoietic cells contributes to cardiovascular disease. Comparative analyses showed that inactivation of Tet2 and Dnmt3 was similar in their ability to promote Ang II-induced cardiac dysfunction and renal fibrosis in mice. However, gene-specific actions were indicated by differences in kinetics of hematopoietic stem/progenitor cell expansion and different patterns of inflammatory gene expression.
The neurobiological basis of musical expectations (2012)

This article explores how the auditory system processes incoming information and generates perceptual representations that allow it to make predictions about future sound events from past context, and how music appears to make use of this general processing mechanism. It focuses on expectation formation in auditory cortex because this is where the most research has been done, but there is also evidence for prediction mechanisms at subcortical levels and at levels beyond sensory areas. The article presents a framework for thinking about the neurological basis of expectation and prediction in musical processing using selected examples.
Synthesis, Molecular Modeling, and Biological Studies of Novel Piperidine-Based Analogues of Cocaine:  Evidence of Unfavorable Interactions Proximal to the 3α-Position of the Piperidine Ring (2004)

A qualitative model for the binding pocket proximal to the 3alpha-substituent of the piperidine-based monoamine transporter ligands was proposed and tested. Based on this model, a new series of druglike 3alpha-modified piperidine-based analogues of cocaine were designed, synthesized, and studied for their ability to inhibit reuptake of DA, 5-HT, and NE by the DA, 5-HT, and NE transporters. We found that the insertion of at least one additional methylene group between the piperidine ring and the polar group in the 3alpha-substituent dramatically improves the activity of the compounds that are generally inactive without this additional linker. Molecular modeling analysis showed that the more flexible 3alpha-substituents can avoid unfavorable interactions with the binding sites of DAT, SERT, and NET. The present results may have important implications for the elucidation of the structural differences between DA, 5-HT, and NE transporters and for the further design of new leads for development of cocaine abuse medication as well as certain neurological disorders such as ADHD and depression.
Preparation of Monodisperse Biodegradable Polymer Microparticles Using a Microfluidic Flow‐Focusing Device for Controlled Drug Delivery (2009)

Degradable microparticles have broad utility as vehicles for drug delivery and form the basis of several therapies approved by the US Food and Drug Administration. Conventional emulsion-based methods of manufacturing produce particles with a wide range of diameters (and thus kinetics of release) in each batch. This paper describes the fabrication of monodisperse, drug-loaded microparticles from biodegradable polymers using the microfluidic flow-focusing (FF) devices and the drug-delivery properties of those particles. Particles are engineered with defined sizes, ranging from 10 microm to 50 microm. These particles are nearly monodisperse (polydispersity index = 3.9%). A model amphiphilic drug (bupivacaine) is incorporated within the biodegradable matrix of the particles. Kinetic analysis shows that the release of the drug from these monodisperse particles is slower than that from conventional methods of the same average size but a broader distribution of sizes and, most importantly, exhibit a significantly lower initial burst than that observed with conventional particles. The difference in the initial kinetics of drug release is attributed to the uniform distribution of the drug inside the particles generated using the microfluidic methods. These results demonstrate the utility of microfluidic FF for the generation of homogenous systems of particles for the delivery of drugs.
A fragment of human TrpRS of ocular angiogenesis (2016)

Pathological angiogenesis contributes directly to profound loss of II vision associated with many diseases of the eye. Recent work er suggests that human tyrosyland tryptophanyl-tRNA synthetases tin (TrpRS) link protein synthesis to signal transduction pathways in including angiogenesis. In this study, we show that a recombinant T: form of a COOH-terminal fragment of TrpRS is a potent antagonist la of vascular endothelial growth factor-induced angiogenesis in a la mouse model and of naturally occurring retinal angiogenesis in the et neonatal mouse. The angiostatic activity is dose-dependent in both ge systems. The recombinant fragment is similar in size to one genle erated naturally by alternative splicing and can be produced by e) proteolysis of the full-length protein. In contrast, the full-length N protein is inactive as an antagonist of angiogenesis. These results suggest that fragments of TrpRS, as naturally occurring and poT: tentially nonimmunogenic anti-angiogenics, can be used for the T: treatment of neovatcular eye diseases. te
Study on Nanostructurization Material and its Application for Photocatalytic (2014)

Titanium dioxide (TiO 2 ) is one of the prospective catalysts because it possesses excellence properties (e.g., chemical and thermal stability, harmless, and inexpensive). With these advantages, the production
Large-scale secondary structures in duct flow (2004)

The spatial growth of small perturbations developing on a fully developed base flow in a duct with two inhomogeneous cross-flow directions is examined. For a laminar mean flow it is shown that optimally configured vortices at an upstream cross-section induce large transient amplification of a disturbance energy norm downstream. Such a linear growth is a likely initial stage of transition in ducts for which the cross-section is square or of moderate aspect ratio, asymptotically stable according to conventional eigen-analyis. With the increase of the cross-sectional aspect ratio the transient growth results of the plane channel flow case are approached. The optimization methodology is then employed to study the transient amplification of large-scale secondary structures developing in a square duct for which the unidirectional base motion has a turbulent-like profile. Under the hypothesis that fine-scale turbulence does not affect the growth of large-scale secondary flows, it is shown that cross-stream vortices are sustained by the mean flow and grow maximally over a streamwise distance of several thousand viscous units of length.
Delivery and Targeting of Therapeutic Cells (2015)

Nature uses cell targeting in a number of physiological processes. Examples include the homing, or migration, of leukocytes to the sites of inflammation, the plugging of breaches in the vasculature by platelets, lodging of circulating tumour cells at sites of metastasis, and the homing of cells to tumours and sites of injury. Cells can also be engineered to migrate to a target by inserting specific recognition molecules into the cell membrane. These recognition molecules can be peptides, antibodies, and other affinity ligands. Peptides are particularly useful for this purpose because they can be readily synthesised with a lipid tail to enable insertion into the cell membrane. The vasculature expresses a multitude of molecular docking sites that are specific for a given tissue or pathological lesion such as cancer, atherosclerosis, injury, or inflammation. With specific molecular ligands, cells can be specifically targeted to such docking sites. In this review, we examine the optimal method for delivery of cells into the body, and the potential of natural and engineered cell targeting in therapeutic applications.
Porosity for the penetrable-concentric-shell model of two-phase disordered media: Computer simulation results (1988)

Computer-simulation results are reported for the porosity of a model of two-phase random media composed of identical D-dimensional spheres (D=2 or 3) distributed with an arbitrary degree of impenetrability λ, 0≤λ≤1; λ=0 corresponding to randomly centered or ‘‘fully penetrable’’ particles and λ=1 corresponding to totally impenetrable particles. We specifically consider the D-dimensional penetrable-concentric-shell model in which each sphere of diameter σ is composed of a mutually impenetrable core of diameter λσ, encompassed by a perfectly penetrable concentric shell of thickness (1−λ)σ/2. We develop two independent techniques to sample for the porosity. Simulation results agree with known exact results for the extreme limits of λ=0 and λ=1 up to three significant figures. The results for intermediate λ are new and compare favorably with approximate analytical expressions obtained by Rikvold and Stell.
A low-cost, miniature CTD for animal-borne ocean measurements (2010)

The study of fine-scale linkages between animal behavior and the physical microstructure of the marine habitat is essential for understanding the ecology of many marine animals. Animal-borne salinity data has the potential to define the importance of physical water mass features to the ecology of marine animals. Recently CTD (conductivity, temperature and depth) data loggers mounted on large marine mammals (pinnipeds and cetaceans) have been able to capture direct qualitative information on the physical microstructure of the foraging environment and microhabitat. In order to understand the physical environment of smaller marine animals (penguins, fish and reptiles) a miniature, inexpensive CTD biologger is being developed. The biologger circuit boards are of a modular design so that several prototypes for different marine species can be developed. Currently two designs (A and B) have been fabricated and they measure 50 × 25 × 25 mm and 85 × 25 × 15 mm (unpotted), respectively. The biologger has additional internal sensors that are managed by a low-power microcontroller. The complete multisensor system measures conductivity, temperature, pressure, light, three-axis acceleration, three-axis magnetic fields, wet/dry and GPS. CTD measurements are used to calculate salinity and must be in close proximity to one another and the seawater. Therefore a novel CTD board was fabricated. The conductivity sensor was fabricated using printed circuit board (PCB) techniques and integrated with MEMS (micromechanoelectrical system) sensors, a thermistor and piezoresitive pressure module, on a liquid crystal polymer substrate (LCP). A four-electrode conductivity circuit that measures electrical resistance was designed. In this paper the biologger initial design is presented along with the conductivity cell circuit and preliminary CTD characterization data.
Informação e conceituação: a dimensão cognitiva da desigualdade política entre jovens de Belo Horizonte (2011)

O presente artigo discute o conceito, a mensuração e os processos por meio dos quais os cidadãos adquirem conhecimento político. Discutimos, primeiramente, a elaboração analítica e a mensuração do conhecimento político em pesquisas empíricas na ciência política. Em seguida, criamos indicadores dos dois tipos principais de conhecimento: a informação factual e o conhecimento conceitual. O último passo consistiu em averiguar, por meio da análise estatística multivariada, os processos por meio dos quais os jovens adquirem os dois tipos de conhecimento.
Direct Observation of Field Emission Sites in a Single Multiwalled Carbon Nanotube by Lorenz Microscopy (2005)

Emission sites were observed as bright spots near the tip end of a multiwalled carbon nanotube (MWNT) by means of Lorenz microscopy. The bright spots appeared above electric fields as electrons were emitted. A marked fluctuation was observed in the emission current above 20–30 µA, which was closely related to structural changes at the tip of the MWNT. The layers of the MWNT were peeled off during field emission and they functioned as the second emission sites for the concentration of electric field.
Integration aspects of a polymer based SPR biosensor with active micro optical and micro fluidic elements (2007)

S.295-302
Impairment of the ubiquitin‐proteasome system by cellular FLIP (2007)

Cellular FLIP (cFLIP) is a homologue of caspase-8 without protease activity that inhibits the apoptosis signaling initiated by death receptor ligation. We previously reported that a long form of cFLIP (cFLIP-L) inhibits ubiquitylation of beta-catenin and enhances Wnt signaling. Here we show that cFLIP-L impairs the function of the ubiquitin-proteasome system (UPS), and increases the accumulation of various short-lived proteins, such as GFP conjugated with destabilization sequence, beta-catenin and HIF1 alpha, that are subjected to rapid ubiquitylation and degradation by proteasomes. Accordingly, beta-catenin- and HIF1 alpha-mediated gene expressions are induced in the cFLIP-L-expressing cells. Exogenously expressed cFLIP-L accumulates in aggregates at the peri-nuclear region in the cells, and the cFLIP-L aggregates are refractory to solubilization. Like exogenously expressed cFLIP-L, the endogenous cFLIP in A549 lung cancer cells displays particulate distribution in the cells and more than 60% of cFLIP-L is refractory to solubilization. Down-regulation of cFLIP in A549 cells by RNA-mediated interference reduced beta-catenin- and HIF1 alpha-mediated gene expression. These results suggest that cFLIP-L is prone to aggregate and impairs UPS function, which could be involved in the pathological function of cFLIP-L expressed in certain cancer cells.