gebhart/patrepeval huggingface dataset:
Resistance of differentiated human airway epithelium to infection by rhinovirus (2004)

Virtually all in vitro studies of the effects of rhinovirus on human airway epithelium have used cells grown under conditions known to produce low levels of differentiation. The relevance of the results to native epithelium is questionable. Here we grew primary cultures of human tracheal or nasal epithelium under three conditions. One condition produced pseudostratified, mucociliary cells virtually indistinguishable from native epithelium. The other two conditions produced undifferentiated squamous cells lacking cilia. Cells were infected for 6 h with rhinovirus-16. After a 24-h incubation period, we determined levels of viral RNA in the cells, numbers of infectious viral particles released in the mucosal medium, expression of a variety of epithelial cytokines and other proteins, release of IL-6 and IL-8, and transepithelial electrical resistance and voltage. After infection, levels of viral RNA in the poorly differentiated cells were 30 or 130 times those in the differentiated. Furthermore, expression of mRNA for inflammatory cytokines, release of infectious particles, and release of IL-6 and IL-8 were closely correlated with the degree of viral infection. Thus well-differentiated cells are much more resistant to viral infection and its functional consequences than are poorly differentiated cells from the same source.
Ten-micron instrument MIDI: getting ready for observations on the VLTI (2003)

The mid-infrared interferometric instrument MIDI is currently undergoing testing in preparation for commissioning on the Very Large Telescope Interferometer VLTI at the end of this year 2002. It will perform interferometric observations over the 8 &mu;m - 13 &mu;m wavelength range, with a spatial resolution of 20 milliarcsec, a spectral resolution of up to 250, and an anticipated point source sensitivity of N = 4 mag or 1 Jy for self-fringe tracking, which will be the only observing mode during the first months of operation. We describe the layout of the instrument and the performance during laboratory tests, both for broadband and spectrally resolved observing modes. We also briefly outline the planned guaranteed time observations.
Feeling Rejected? ACS Chemical Neuroscience Can Help Get Your Science to the Neuroscience Community As Quickly As Possible (2017)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTFeeling Rejected? ACS Chemical Neuroscience Can Help Get Your Science to the Neuroscience Community As Quickly As PossibleCraig W. LindsleyCite this: ACS Chem. Neurosci. 2017, 8, 11, 2348Publication Date (Web):November 15, 2017Publication History Published online15 November 2017Published inissue 15 November 2017https://pubs.acs.org/doi/10.1021/acschemneuro.7b00380https://doi.org/10.1021/acschemneuro.7b00380editorialACS PublicationsCopyright © 2017 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views933Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (175 KB) Get e-AlertscloseSUBJECTS:Chemical neuroscience,Neuroscience,Quality management,Targeting Get e-Alerts
ChemInform Abstract: Synthesis of Oxygenated Cholesterols as Structural Mimics of Phorbol Ester‐Type Tumor Promoters. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Backbone Amide Linker (BAL) Strategy for Solid‐Phase Synthesis (2001)

The first part of this chapter describes the preparation of 4-formyl-3,5-dimethoxyphenol (pure isomer) by Vilsmeier formylation of 3,5-dimethoxyphenol. The second part of this chapter describes the quantitative coupling of p-PALdehyde or o,p-PALdehyde to an amino-functionalized solid support poly(ethylene glycol)-polystyrene graft (PEG-PS) via a BOP/HOBt/DIEA (2:3:3) or HATU/DIEA (1:2) mediated coupling. These procedure yield the p-PALdehyde-resin-or o,p-PALdehyde-resin. Subsequently, attachment of the C-terminal amino acid residue through its amino group is carried out. Finally, the authors describe acylation of the sterically hindered secondary α-amino group attached to the BAL-anchor.
Two- and three-body interactions among nanoparticles in a polymer melt (2011)

We perform direct three-dimensional density functional theory (DFT) calculations of two- and three-body interactions in polymer nanocomposites. The nanoparticles are modeled as hard spheres, immersed in a hard-sphere homopolymer melt of freely jointed chains. The two-particle potential of mean force obtained from the DFT is in near quantitative agreement with the potential of mean force obtained from self-consistent polymer reference interaction site model theory. Three-body interactions among three nanoparticles are found to be significant, such that it is not possible to describe these systems with a polymer-mediated two-body interaction calculated from the potential of mean force.
Anti-CD28 Monoclonal Antibody Therapy Prevents Chronic Rejection of Renal Allografts in Rats (2002)

The effects of a signaling anti-CD28 mAb (JJ319), which interferes with the CD28-B7 T cell costimulation pathway thought to be involved in the development of chronic rejection of organ transplants, was investigated. Functional, morphologic, and molecular changes in rat renal allografts were examined up to 24 wk after placement. Control Lewis rats, recipients of F344 kidneys, received a single dose of a nonspecific mouse mAb intravenously on the day of transplantation (group 1). Group 2 animals were given anti-CD28 mAb in similar fashion. Group 3 animals were treated with a short course of cyclosporin A (CsA), and group 4 received both anti-CD 28 mAb and CsA. The majority (>95%) of animals in groups 2, 3, and 4 survived throughout the follow-up, compared with 28% in group 1 (P < 0.001). Group 2 and 4 recipients produced negligible proteinuria, whereas group 1 controls developed progressively increasing proteinuria after 4 wk and group 3 animals developed proteinuria by 24 wk. Allografts in groups 2 and 4 were morphologically unremarkable at 24 wk. Kidneys of group 1 animals rapidly developed changes of acute rejection, and those that survived long-term showed extensive glomerulosclerosis and interstitial fibrosis. Changes of early chronic rejection were noted in group 3 grafts. By reverse transcriptase-PCR, expression of representative inflammatory factors interferon-gamma and interleukin-10 were significantly elevated at 24 wk only in the surviving group 1 animals. A single dose of a signaling anti-CD28 mAb administered at transplantation or in combination with a short course of CsA significantly prolonged recipient survival, normalized function, and preserved the morphology of renal allografts in an established model of chronic rejection. These data support an important role for T cell costimulation in the evolution of the chronic process.
The Bitome: digitized genomic features reveal fundamental genome organization (2020)

Abstract A genome contains the information underlying an organism's form and function. Yet, we lack formal framework to represent and study this information. Here, we introduce the Bitome, a matrix composed of binary digits (bits) representing the genomic positions of genomic features. We form a Bitome for the genome of Escherichia coli K-12 MG1655. We find that: (i) genomic features are encoded unevenly, both spatially and categorically; (ii) coding and intergenic features are recapitulated at high resolution; (iii) adaptive mutations are skewed towards genomic positions with fewer features; and (iv) the Bitome enhances prediction of adaptively mutated and essential genes. The Bitome is a formal representation of a genome and may be used to study its fundamental organizational properties.
Component Testing and Prototype Commissioning of MAN’s New Gas Turbine in the 6 MW-Class (2012)

MAN Diesel &amp; Turbo has developed a new gas turbine in the 6 MW-class for both mechanical drive and power generation applications. The lay-out of the Gas Turbine has been driven by opportunities in current and future markets and the positioning of the competition, and this has determined the characteristics and technical parameters which have been optimized in the 6 MW design. The design makes use of extremely high precision engineering so that the assembly of sub components to modules is a smooth flowing process and can guarantee both the high standards in quality and performance which MAN Diesel &amp; Turbo is aiming for. Individual components have been tested and thoroughly validated. These tests include in particular the compressor of the gas turbine and the combustion chamber. The commissioning of the gas turbine prototype engine had been prepared with a numerous number of measuring probes and carried out at the Oberhausen plant gas turbine test field. Results of component and the gas turbine prototype tests will be presented and discussed.
Lanthanide Class of a Trinuclear Enantiopure Helical Architecture Containing Chiral Ligands: Synthesis, Structure, and Properties (2007)

The pinene-bipyridine carboxylic derivatives (+)- and (-)-HL, designed to form configurationally stable lanthanide complexes, proved their effectiveness as chiral building blocks for the synthesis of lanthanide-containing superstructures. Indeed a self-assembly process takes place with complete diastereoselectivity between the enantiomerically pure ligand L(-) and Ln(III) ions (La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er), thus leading to the quantitative formation of a trinuclear supramolecular architecture with the general formula [Ln(3)(L)(6)(mu(3)-OH)(H(2)O)(3)](ClO(4))(2) (abbreviated as tris(Ln[L](2))). This class of C(3)-symmetrical compounds was structurally characterized in the solid state and solution. Electrospray (ES) mass spectrometric and (1)H NMR spectroscopic analyses indicated that the trinuclear species are maintained in solution (CH(2)Cl(2)) and are stable in the investigated concentration range (10(-2)-10(-6) m). The photophysical properties of the ligand HL and its tris(Ln[L](2)) complexes were studied at room temperature and 77 K, thus demonstrating that the metal-centered luminescence is well sensitized both for the visible and near-IR emitters. The chiroptical properties of tris(Ln[L](2)) complexes were investigated by means of circular dichroism (CD) and circularly polarized luminescence (CPL). A high CD activity is displayed in the region of pi-pi* transitions of bipyridine. CPL spectra of tris(Eu[(+)-L](2)) and tris(Tb[(+)-L](2)) present large dissymmetry factors g(em) for the sensitive transitions of Eu(III) ((5)D(0)-->(7)F(1), g(em)=-0.088) and Tb(III) ((5)D(4)-->(7)F(5), g(em)=-0.0806). The self-recognition capabilities of the system were tested in the presence of artificial enantiomeric mixtures of the ligand. (1)H NMR spectra identical to those of the enantiomerically pure complexes and investigations by CD spectroscopic analysis reveal an almost complete chiral self-recognition in the self-assembly process, thus leading to mixtures of homochiral trinuclear structures.
New unidirectional hybrid delta-switch rectifier (2011)

This paper introduces a novel 3-phase hybrid rectifier assembled by the parallel connection of a 3-phase diode bridge boost rectifier with a 2-level unidirectional delta-switch rectifier. This system aims to take advantage of the commonly low power losses and high reliability of a diode based rectifier and also to benefit from the delta-rectifier capability of processing reactive power. Therefore, a highly efficient and reliable high power factor rectifier system with controlled dc-link voltage is constructed. Additionally, this work presents an efficiency comparison between the proposed hybrid delta-switch rectifier and other concepts such as the new 3-level unidirectional hybrid T-type or VIENNA 6-switch rectifiers and the single self-commuted converters, including the VIENNA 6-switch, delta-switch and T-type rectifiers for 10 kW 50 Hz operation. It is shown that the hybrid systems can achieve higher efficiency than the single self-commuted rectifier they are based on. Finally, experimental results obtained with an assembled unidirectional hybrid delta-switch rectifier prototype are presented in order to demonstrate the performance and feasibility of this solution.
Supplementary Figure 4 from MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-α, in Patients with Advanced Liver Cancer: A First-in-Human, Multicenter, Open-Label, Phase I Trial (2023)

&lt;p&gt;A) CT and MRI of patient with prolonged partial response with MTL-CEBPA treatment B) IFN-gamma, NFkB and IL6 trend at days 1, 8 and 15 following treatment and C) AFP change at from baseline to 4, 8 and 16 weeks on treatment&lt;/p&gt;
Alterations in correlated activity parallel ICMS-induced representational plasticity (1993)

We studied neural interactions by cross correlation analysis during representational plasticity induced by intracortical microstimulation (ICMS). Neuron pairs were simultaneously recorded in area 3b in adult New World monkeys, and in cortical field SI in adult rats. In normal animals, the degree of correlated spontaneous activity corresponded to the extent of receptive field overlap. After several hours of ICMS, the spatial extents of cortex over which correlated activity could be recorded was enlarged several-fold. Mapping experiments revealed that increased correlated activity was only recorded within that cortical sector that was representationally reorganized, indicating a close relationship between cortical reorganization and cooperative processes. Results support the hypothesis that discharge coincidence is crucial for the formation of functionally coupled neural groups, and implicate dynamically maintained groups in the genesis of postontogenetic plasticity.
Importance of Bubble Size Control in Ultrasonic Surface Cleaning by Pulsed High-Frequency Sound Fields (2013)

Various industrial processes such as sonochemical processing and ultrasonic cleaning strongly rely on the phenomenon of acoustic cavitation. As the occurrence of acoustic cavitation is incorporating a multitude of interdependent effects, the amount of cavitation activity in a vessel is strongly depending on the ultrasonic process conditions. It is therefore crucial to quantify cavitation activity as a function of the process parameters. At 1 MHz, the active cavitation bubbles are so small that it is becoming difficult to observe them in a direct way. Hence, another metrology based on secondary effects of acoustic cavitation is more suitable to study cavitation activity. In this paper we present a detailed analysis of acoustic cavitation phenomena at 1 MHz ultrasound by means of time-resolved measurements of sonoluminescence, cavitation noise, and synchronized high-speed stroboscopic Schlieren imaging. It is shown that a correlation exists between sonoluminescence, and the ultraharmonic and broadband signals extracted from the cavitation noise spectra. The signals can be utilized to characterize different regimes of cavitation activity at different acoustic power densities. When cavitation activity sets on, the aforementioned signals correlate to fluctuations in the Schlieren contrast as well as the number of nucleated bubbles extracted from the Schlieren Images. This additionally proves that signals extracted from cavitation noise spectra truly represent a measure for cavitation activity. The cyclic behavior of cavitation activity is investigated and related to the evolution of the bubble populations in the ultrasonic tank. It is shown that cavitation activity is strongly linked to the occurrence of fast-moving bubbles. The origin of this ''bubble streamers'' is investigated and their role in the initialization and propagation of cavitation activity throughout the sonicated liquid is discussed. Finally, it is shown that bubble activity can be stabilized and enhanced by the use of pulsed ultrasound by conserving and recycling active bubbles between subsequent pulsing cycles.
From the Editor in Chief: Who You Gonna Call? (2002)

Users have a few options for locating services on the Internet, but the real challenge is how to find parties that are trustworthy and contextually appropriate.
General Strategy for the Synthesis of Rigid Weak-Link Approach Platinum(II) Complexes: Tweezers, Triple-Layer Complexes, and Macrocycles (2013)

Air-stable, heteroligated platinum(II) weak-link approach (WLA) tweezer and triple-layer complexes that possess P,X-Aryl hemilabile ligands (P^ = Ph2PCH2CH2-, X = chalcoethers or amines) have been synthesized via the halide-induced ligand rearrangement (HILR) reaction, using a one-pot, partial chloride-abstraction method. The approach is general and works with a variety of phosphine-based hemilabile ligands; when a P,S-Ph ligand is used as the relatively strongly chelating ligand, heteroligated complexes are formed cleanly when an ether- (P,O-Ph), amine- (P,N-Ph2), or fluorinated thioether-based (P,S-C6F4H) hemilabile ligand is used as the weakly chelating counterpart. The HILR reaction has also been used to synthesize bisplatinum(II) macrocycles free of oligomeric material without having to resort to the high-dilution conditions typical for macrocycle synthesis. This approach is complementary to the traditional WLA to the synthesis of macrocyclic complexes which typically proceeds via fully closed, chloride-free intermediates. The structures of the complexes may be toggled between semiopen (with only one chelating ligand) and fully closed (with both ligands chelating) via the abstraction and addition of chloride.
A single-chain immunotoxin against carcinoembryonic antigen that suppresses growth of colorectal carcinoma cells. (1998)

We have engineered an anti-carcinoembryonic antigen (CEA) single-chain immunotoxin derived from humanized anti-CEA antibody (hMN14) and a truncated Pseudomonas exotoxin (PE), PE40. The purified anti-CEA immunotoxin (hMN14(Fv)-PE40) was first measured for binding affinity against a CEA-positive colorectal carcinoma cell line and compared with its parental IgG and the monovalent Fab fragment. The Ka of sFv-PE40, Fab, and IgG were 5 x 10(7), 6 x 10(7), and 3 x 10(8) M(-1), respectively. There was no significant affinity loss by conversion of Fab to the single-chain Fv, but these monovalent forms were 5-6-fold reduced in affinity compared with the parental IgG. In cytotoxicity assays, the hMN14(Fv)-PE40 showed specific growth suppression of CEA-expressing colon cancer cell lines MIP-CEA (high CEA) and LS174T (moderate CEA) with IC50s of 12 ng/ml (0.2 nM) and 69 ng/ml (1.1 nM). These IC50s correlated inversely with the surface expression of CEA, such that 50% killing was equivalent for each cell type when expressed in toxin molecules bound/cell (3000-5000). The presence of soluble CEA up to 1000 ng/ml did not affect the cytotoxicity against CEA-expressing cells, with 50% suppression only at 4000 ng/ml that correlated with the binding Kd of the single-chain Fv. The stability of the hMN14(Fv)-PE40 molecule at 37 degrees C was confirmed by bioassay and by lack of aggregation. Our hMN14(Fv)-PE40 may be clinically useful for tumors with high CEA expression without affecting normal tissues with low or absent CEA, even in patients with high soluble antigen levels.
Interplay Between Galanin and Leptin in the Hypothalamic Control of Feeding via Corticotropin-Releasing Hormone and Neuropeptide Y (2001)

Over long periods, feeding and metabolism are tightly regulated at the central level. The total amount of nutrients ingested is thought to result from a delicate balance between orexigenic and anorexigenic factors expressed and secreted by specialized hypothalamic neuronal populations. We have developed a system of perifused hypothalamic neurons to characterize the relationships existing between the orexigenic peptide galanin and two other physiological modulators of feeding: neuropeptide Y (NPY) and corticotropin-releasing hormone (CRH). We demonstrated that galanin stimulates CRH and NPY secretion from hypothalamic neurons in a dose-dependent manner. Exposure to leptin for 24 h before galanin stimulation decreased NPY secretion by 30%, leaving the responsiveness of CRH neurons intact. These results suggest that CRH and NPY neurons participate to the intrahypothalamic signaling pathway of galanin, an observation that can explain the lower potency of galanin to stimulate food intake in vivo compared with NPY. The differential effects exerted by leptin on CRH and NPY suggest that there exists a subset of NPY neurons that are exquisitely sensitive to marked variations in leptin levels, and that the CRH neurons are less responsive to increases in leptin concentrations.
Broadband optical comb generation using Mach-Zehnder-modulator-based flat comb generator with feedback loop (2010)

We demonstrated broadband comb generation using a Mach-Zehnder-modulator-based flat comb generator with a feedback loop. By constructing the feedback loop, the modulation depth was increased. A generated comb signal was broadened as compared with single-path configuration.
Computational system for multi disciplinary optimization at conceptual design stage (2008)

Presented is a computational system for multidisciplinary design optimization (MDO) at the conceptual design stage. During this phase, hundreds of low-fidelity models such as equations and compiled code, and thousands of variables are used to describe a complex product such as aircraft. In this context the paper presents a novel computational approach associated with the complete MDO process. The first aspect of the proposed approach is the dynamic derivation of the optimal computational plan for each design study, given the designer's choice of independent variables. The second aspect is the effectiveness with which the trade-off landscape is obtained. This is crucial from an engineering point of view, since such information will be used for selecting a baseline design. The approach is demonstrated with an aircraft design test case consisting of 96 models and 120 variables.
Demonstration of automatic address and radio parameters assignment in MANET using DHCP protocol extensions (2009)

We propose procedures for autoconfiguration of multihop wireless ad-hoc networks based on DHCP protocol. The proposed mechanism provides automatic address and radio parameters set-up for nodes with multiple radio interfaces, allowing to fully automatically form and to start a wireless mesh network and to route packets. The autoconfiguration schema was implemented and tested on OpenWRT platform. The demonstration shows how multiple Mikrotik routerboard with three 802.11g interfaces can fully automatically create a multihop wireless network, assign IP addresses, radio channels. It will also include the automatic visualization of network topology by network management software.