gebhart/patrepeval huggingface dataset:
T cell-induced B cell blasts differentiate into plasma cells when cultured on bone marrow stroma with IL-3 and IL-10 (1995)

B lymphocytes activated by T cells in secondary lymphoid organs mature into plasma cells after migration into the medullary cords of these organs, mucosal lamina propria or bone marrow. To analyze each step leading to plasma cell generation, we set up a two-step culture system of purified tonsillar B cells. In a primary stage, B cell blasts were generated by co-culturing B cells with an irradiated T cell clone activated with immobilized anti-CD3. In a secondary step, culturing these blasts on bone marrow stromal cells (BMSC) induced them to secrete large amounts of IgG, as well as some IgM and IgA. Other fibroblast-like cell lines were less efficient at sustaining the differentiation of blasts into Ig-secreting cells, suggesting that these are specific properties of BMSC. Addition of IL-3 and IL-10 further stimulated IgG secretion by B cell blasts cultured on BMSC, mostly the IgG1 subclass. These two cytokines probably acted through different pathways, as (i) the effect of IL-3 but not IL-10 was dependent upon prolonged T cell pre-activation and (ii) their combined stimulatory effect was additive. B cell blasts cultured on BMSC with a combination of IL-3 and IL-10 differentiated into non-proliferating plasma cells as determined by poor thymidine incorporation, typical cellular morphology, intense expression of intracytoplasmic Igs, very high levels of surface CD38 and lack of surface CD20.
Supplementary Table 2 from Identification of Epigenetically Silenced Genes in Tumor Endothelial Cells (2023)

Supplementary Table 2 from Identification of Epigenetically Silenced Genes in Tumor Endothelial Cells
Effective Coupling Factors for Series and Parallel Tuned Secondaries in IPT Systems Using Bipolar Primary Pads (2017)

Inductive power transfer is a method of delivering power from a source to a load by resonating inductive coils in proximity with each other. Two main pad topologies exist: one that can generate nonpolarized and one that can generate polarized fields. Multicoil pads such as bipolar pads (BPPs) have been proposed as a pad topology that is interoperable with both polarized and nonpolarized pads. BPPs comprise two ideally overlapped mutually decoupled coils, which can be driven in any relative magnitude or phase. A polarized pad structure, such as a double d pad, is not equivalent to a BPP, and the polarized pad is a subset of the multicoil pad. It also shows that the effective coupling factor (keff) between the BPP primary and the secondary depends on the coupling factors that exist between each primary coil and the secondary coil, the reflected impedances, and the relative magnitude and phase of currents between the primary coils. An equation that describes keff is proposed and considers all these factors to show how each coil in a BPP can be energized to control VA transfer.
A revised method for calculation of life expectancy tables from individual death records which provides increased accuracy at advanced ages. (1981)

The authors present a revised method for calculating life expectancy tables for populations where individual ages at death are known or can be estimated. The conventional and revised methods are compared using data for U.S. and Hungarian males in an attempt to determine the accuracy of each method in calculating life expectancy at advanced ages. Means of correcting errors caused by age rounding, age exaggeration, and infant mortality are presented
High temperature superconductors at high frequencies (1989)

Many of the high frequency applications of superconductors depend on their low high frequency losses. However, the much weaker frequency dependence for normal metals means that at high enough frequencies the surface impedance of say cold copper is comparable to that of the superconductor. This crossover frequency is a simple measure of material performance. It should rise as the sample is cooled further. At present the best in-situ films can have crossover frequencies well over 300 GHz when measured at 77 K. Even post-annealed films can get above 50 GHz, depending on the superconductor orientation and the presence of second phases. At lower frequencies the margin of advantage over normal metals increases. There is every reason to believe that the present day performance is not fundamental, and that further improvements in the crystallinity and purity of the films will be reflected in their high frequency performance. >
Degenerate PCR primers for the amplification of fragments from genes encoding response regulators from a range of pathogenic bacteria (1992)

Many bacterial responses to environmental stimuli are mediated by response regulators which coordinately regulate genes involved in particular adaptive responses. Degenerate oligonucleotide primers were used to amplify by the polymerase chain reaction (PCR), fragments from genes encoding eleven novel response regulators. Sequence and phylogenetic analysis revealed that phoB, phoP and creB gene fragments had been amplified from Yersinia enterocolitica and Yersinia pseudotuberculosis, and that a creB sequence had been amplified from Campylobacter jejuni. Four amplified fragments from C. jejuni, Listeria monocytogenes, Mycobacterium tuberculosis and Escherichia coli clearly came from response regulator genes, but were not closely related to any of the known genes. Mutagenesis of the newly identified genes should allow us to determine their function and the genes under their control.
Comparison of two low-noise CEP stabilization methods for an environmentally stable Yb:fiber oscillator (2019)

We demonstrate a low-noise carrier-envelope-offset frequency stabilized all-PM Yb:fiber oscillator. Two different stabilization methods lead to sub 200 mrad integrated fo phase noise (10 Hz to 1 MHz), suitable for comb spectroscopy applications. © 2019 The Author(s)
Data from Neural Tumor-Initiating Cells Have Distinct Telomere Maintenance and Can be Safely Targeted for Telomerase Inhibition (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Cancer recurrence is one of the major setbacks in oncology. Maintaining telomeres is essential for sustaining the limitless replicative potential of such cancers. Because telomerase is thought to be active in all tumor cells and normal stem cells, telomerase inhibition may be nonspecific and have detrimental effects on tissue maintenance and development by affecting normal stem cell self-renewal.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; We examined telomerase activity, telomere maintenance, and stem cell maturation in tumor subpopulations from freshly resected gliomas, long-term, primary, neural tumor-initiating cells (TIC) and corresponding normal stem cell lines. We then tested the efficacy of the telomerase inhibitor Imetelstat on propagation and self-renewal capacity of TIC and normal stem cells &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Telomerase was undetectable in the majority of tumor cells and specific to the TIC subpopulation that possessed critically short telomeres. In contrast, normal tissue stem cells had longer telomeres and undetectable telomerase activity and were insensitive to telomerase inhibition, which results in proliferation arrest, cell maturation, and DNA damage in neural TIC. Significant survival benefit and late tumor growth arrest of neuroblastoma TIC were observed in a xenograft model (&lt;i&gt;P&lt;/i&gt; = 0.02). Furthermore, neural TIC exhibited irreversible loss of self-renewal and stem cell capabilities even after cessation of treatment &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; TIC exhaustion with telomerase inhibition and lack of telomerase dependency in normal stem cells add new dimensions to the telomere hypothesis and suggest that targeting TIC with telomerase inhibitors may represent a specific and safe therapeutic approach for tumors of neural origin. &lt;i&gt;Clin Cancer Res; 17(1); 111–21. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Service control layer (SCL) (2008)

Telecom operators have started to make significant investments towards evolving their Service Delivery Platforms (SDPs) to a next-generation architecture based on IP technologies and standards such as SIP, SOA and increasingly, Web 2.0. With consumers and businesses increasingly relying on Web 2.0--oriented services for information, communications, collaboration and entertainment - the key to this evolution would be the integration of Web/SOA middleware and Telecom middleware infrastructure, thereby creating a converged Web-Telecom services layer. To this end, operators are gradually embracing the IP Multimedia Subsystem (IMS) and looking at developing an ecosystem of IMS/SIP--based services that can be mashed up with Web--based applications, in innovative ways. Service delivery is vital for the success of the IMS--based approach. To this end, operators will require greater flexibility around real--time management, control and enhancement of user services at runtime - in a manner that is decoupled from the application logic itself. We observe this need and present the Service Control Layer (SCL), a middleware technology that sits between the IMS service and network plane, and provides operators with the requisite fine-grained control and enrichment over the delivery of next-generation converged services.
Polarization rotation due to femtosecond filamentation in an atomic gas (2010)

The linear-to-elliptical transformation of a 400 nm femtosecond-probe pulse in the birefringent filament in argon of an 800 nm linearly polarized femtosecond-pump pulse is studied numerically and experimentally. The rotation of the probe elliptical polarization is the largest in the high-intensity filament core. With propagation, the rotated radiation diffracts outward by the pump-produced plasma. The transmission of the analyzer crossing the probe's polarization is maximum at the pump-probe angle of 45 degrees and gives equal values for each pair of angles symmetrically situated at both sides of the maximum.
Dendrimer Porphyrins and Phthalocyanines (2009)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTDendrimer Porphyrins and PhthalocyaninesWei-Shi Li† and Takuzo Aida*†‡View Author Information ERATO-SORST "Nanospace Project", Japan Science and Technology Agency, National Museum of Emerging Science and Innovation, 2-41 Aomi, Koto-ku, Tokyo 135-0064, Japan, and Department of Chemistry and Biotechnology, School of Engineering, and Centre for NanoBio Integration, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan* To whom correspondence should be addressed. E-mail: [email protected]†Japan Science and Technology Agency.‡The University of Tokyo.Cite this: Chem. Rev. 2009, 109, 11, 6047–6076Publication Date (Web):September 21, 2009Publication History Received9 May 2009Published online21 September 2009Published inissue 11 November 2009https://pubs.acs.org/doi/10.1021/cr900186chttps://doi.org/10.1021/cr900186creview-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views10684Altmetric-Citations275LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Dendrons,Energy transfer,Phthalocyanine,Pyrroles,Zinc Get e-Alerts
Parallel application performance in a shared resource environment (1996)

The utilization of networked, shared, heterogeneous workstations as an inexpensive parallel computational platform is an appealing idea. However, most performance models for parallel computation are oriented towards the use of tightly-coupled, dedicated, homogeneous processors. We develop and validate an analytic performance modelling methodology for synchronous iterative algorithms executing on networked workstations. The model includes the effects of application load, background load, and processor heterogeneity. We use two applications, nonlinear optimization and discrete-event simulation, to validate the model. Various policies for the use of the workstations are considered and the optimal (or near-optimal) scheduling found. The performance modelling methodology provides significant help in addressing scheduling and similar issues in a shared resource environment.
An Overview of Coding Tools in AV1: the First Video Codec from the Alliance for Open Media (2020)

In 2018, the Alliance for Open Media (AOMedia) finalized its first video compression format AV1, which is jointly developed by the industry consortium of leading video technology companies. The main goal of AV1 is to provide an open source and royalty-free video coding format that substantially outperforms state-of-the-art codecs available on the market in compression efficiency while remaining practical decoding complexity as well as being optimized for hardware feasibility and scalability on modern devices. To give detailed insights into how the targeted performance and feasibility is realized, this paper provides a technical overview of key coding techniques in AV1. Besides, the coding performance gains are validated by video compression tests performed with the libaom AV1 encoder against the libvpx VP9 encoder. Preliminary comparison with two leading HEVC encoders, x265 and HM, and the reference software of VVC is also conducted on AOM's common test set and an open 4k set.
Nanoliter injection system for microcolumn liquid chromatography (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNanoliter injection system for microcolumn liquid chromatographyV. L. McGuffin and Milos. NovotnyCite this: Anal. Chem. 1983, 55, 3, 580–583Publication Date (Print):March 1, 1983Publication History Published online1 May 2002Published inissue 1 March 1983https://pubs.acs.org/doi/10.1021/ac00254a038https://doi.org/10.1021/ac00254a038research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
LytR-CpsA-Psr Enzymes as Determinants of Bacillus anthracis Secondary Cell Wall Polysaccharide Assembly (2014)

Bacillus anthracis , the causative agent of anthrax, replicates as chains of vegetative cells by regulating the separation of septal peptidoglycan. Surface (S)-layer proteins and associated proteins (BSLs) function as chain length determinants and bind to the secondary cell wall polysaccharide (SCWP). In this study, we identified the B. anthracis lcpD mutant, which displays increased chain length and S-layer assembly defects due to diminished SCWP attachment to peptidoglycan. In contrast, the B. anthracis lcpB3 variant displayed reduced cell size and chain length, which could be attributed to increased deposition of BSLs. In other bacteria, LytR-CpsA-Psr (LCP) proteins attach wall teichoic acid (WTA) and polysaccharide capsule to peptidoglycan. B. anthracis does not synthesize these polymers, yet its genome encodes six LCP homologues, which, when expressed in S. aureus , promote WTA attachment. We propose a model whereby B. anthracis LCPs promote attachment of SCWP precursors to discrete locations in the peptidoglycan, enabling BSL assembly and regulated separation of septal peptidoglycan.
P‐194L: Late‐News Poster : Through‐Breaking Organic TFT Materials for Active Matrix Display Backplane Application (2010)

Abstract In this paper, e will present a through‐breaking result on new organic TFT materials for AMOLED display backplane application. We have achieved organic TFTs with mobility of ∼ 3 cm 2 /Vs, on/off ratio 10 7 , good uniformity, and estimated bias stress lifetime &gt;10,000hours. This offers a promising route to TFT backplanes for flexible/OLED displays.
Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes (1984)

Amastatin [(2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl-L-valyl-L-valyl-L- aspartic acid] and bestatin [(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl-L-leucine] are slow-binding, competitive inhibitors of aminopeptidase M (AP-M) with net inhibition constants (Ki) of 1.9 X 10(-8) and 4.1 X 10(-6) M, respectively. The effect of inhibitor structure on net Ki and on slow-binding inhibition was evaluated for analogues of both inhibitors on AP-M and leucine aminopeptidase (LAP). The (2S)-hydroxyl group contributes to the stabilization of a collision complex [EI], which is formed rapidly. In contrast, increasing the peptide chain length of the inhibitor produces more potent inhibitors as a consequence of a slower binding process. A statine analogue of amastatin [(3S,4S)-Sta-Val-Val-Asp] stimulated rather than inhibited LAP. AP-M binds tri- and tetrapeptide inhibitors more strongly than dipeptide inhibitors, whereas LAP binds dipeptide inhibitors more strongly. The difference in binding can be used to distinguish cytosolic from membrane-bound aminopeptidases.
COMPUTING The COMBINED EFFECT OF WAKE-PASSING and FREE-STREAM TURBULENCE ON GAS TURBINE BLADE BOUNDARY LAYERS (1992)

Abstract A boundary layer computational procedure has been developed which simultaneously accounts for the time-mean effect of wake-passing and free-stream turbulence on heat transfer to gas turbine blades. The principal advantages of this procedure over others is that it has greater generality and can account fully for both wake- and free-stream turbulence-type unsteadiness. In addition, the procedure is computationally efficient as it can be incorporated into standard two-dimensional steady flow boundary layer codes once the wake effects have been ascertained. The method has been demonstrated for the momentum and mass equations at the stagnation point of a gas turbine blade and some results are presented in this paper.
Finite element approximation for low-frequency sound in a room with absorption (1988)

The two-dimensional flow of acoustic energy is calculated in a room with parallel ceilings and floors and of a rectangular floor plan in the finite element approximation. The interior surfaces of the room are assumed to be reverberant, with the exception of a locally reactive vertical strip of impedance Z=0.7 ρc located on one of walls. Solutions are obtained for a vertically oriented acoustic line source with volumetric flow rate Q per unit length and frequency ω that intersects horizontal planes in the room at the point (x(s),y(s)). The frequency response is calculated by expanding the acoustic Green’s function as the direct product of the damped room eigenmodes, as approximated by the finite element analysis. This approach allows calculation of the room response for various frequencies and source locations in the post processing phase of the finite element solution.
The first C-glycosidic analogue of a novel galactosyltransferase inhibitor (2011)

Structural analogues and mimics of the natural sugar-nucleotide UDP-galactose (UDP-Gal) are sought after as chemical tools for glycobiology and drug discovery. We have recently developed a novel class of galactosyltransferase (GalT) inhibitors derived from UDP-Gal, bearing an additional substituent at the 5-position of the uracil base. Herein we report the first C-glycosidic derivative of this new class of GalT inhibitors. We describe a practical convergent synthesis of the new UDP-C-Gal derivative, including a systematic study into the use of radical chemistry for the preparation of galactosyl ethylphosphonate, a key synthetic intermediate. The new inhibitor showed activity against a bacterial UDP-Gal 4′-epimerase at micromolar concentrations. This is the first example of a base-modified UDP-sugar as an inhibitor of a UDP-sugar-dependent enzyme which is not a glycosyltransferase, and these results may therefore have implications for the design of inhibitors of these enzymes in the future.
The Barrier Molecules Junction Plakoglobin, Filaggrin, and Dystonin Play Roles in Melanoma Growth and Angiogenesis (2019)

FLG and DST support melanoma cell growth in vitro and in vivo. Growth effects of JUP were only evident in vivo, and may be mediated, in part, by enhancing angiogenesis. In addition, growth-promoting effects of FLG and DST in vitro suggest that these genes may also support melanoma cell proliferation through angiogenesis-independent pathways. These findings identify FLG, DST, and JUP as novel therapeutic targets whose down-regulation may provide clinical benefit to patients with melanoma.
Fate and Transport of Molybdenum Disulfide Nanomaterials in Sand Columns (2014)

Research and development of two-dimensional transition metal dichalcogenides (TMDC) (e.g., molybdenum disulfide [MoS<sub>2</sub>]) in electronic, optical, and catalytic applications has been growing rapidly. However, there is little known regarding the behavior of these particles once released into aquatic environments. Therefore, an in-depth study regarding the fate and transport of two popular types of MoS<sub>2</sub> nanomaterials, lithiated (MoS<sub>2</sub>-Li) and Pluronic PF-87 dispersed (MoS<sub>2</sub>-PL), was conducted in saturated porous media (quartz sand) to identify which form would be least mobile in aquatic environments. The electrokinetic properties and hydrodynamic diameters of MoS<sub>2</sub> as a function of ionic strength and pH were determined using a zeta potential analyzer and dynamic light scattering techniques. Results suggest that the stability is significantly decreased beginning at 10 and 31.6 mM KCl, for MoS<sub>2</sub>-PL and MoS<sub>2</sub>-Li, respectively. Transport study results from breakthrough curves, column dissections, and release experiments suggest that MoS<sub>2</sub>-PL exhibits a greater affinity to be irreversibly bound to quartz surfaces as compared with the MoS<sub>2</sub>-Li at a similar ionic strength. Derjaguin-Landau-Verwey-Overbeek theory was used to help explain the unique interactions between the MoS<sub>2</sub>-PL and MoS<sub>2</sub>-Li surfaces between particles and with the quartz collectors. Overall, the results suggest that the fate and transport of MoS<sub>2</sub> is dependent on the type of MoS<sub>2</sub> that enters the environment, where MoS<sub>2</sub>-PL will be least mobile and more likely be deposited in porous media from pluronic-quartz interactions, whereas MoS<sub>2</sub>-Li will travel greater distances and have a greater tendency to be remobilized in sand columns.