gebhart/patrepeval huggingface dataset:
Protection of Lipids from Oxidation by Epicatechin, trans-Resveratrol, and Gallic and Caffeic Acids in Intestinal Model Systems (2006)

Consumption of polyphenols is associated with health promotion through diet, although many are poorly absorbed in animals and humans alike. Lipid peroxides may reach the intestine and initiate deleterious oxidation. Here we measured inhibition of the oxidation of linoleic acid (LA) in authentic fluid from rat small intestine (RIF) by two dietary polyphenols, a flavonoid, epicatechin (EC), and a stilbene, resveratrol (RV), and by gallic (GA) and caffeic (CA) acids, and their partition coefficients. Both polyphenols inhibited 80%, and CA inhibited 65%, of the production of hexanal. GA was the weakest antioxidant in this assay. Interestingly, measuring peroxides production in RIF showed that only epicatechin inhibited the first stage of oxidation. The oxidizing agent, the antioxidant comound, the solution pH and lipophilicity are known to affect the total antioxidative activity. We suggest that the mechanism of this activity changes in accord with the environment: i.e., RV may act as a free radial scavenger, but here, in protecting lipids in intestinal fluid from oxidation, it acts as a hydrogen atom donor. Since the concentration of phenolics is much higher in the intestinal fluid than is ever achieved in plasma or other body tissues, it is suggested that their antioxidant activity could be exerted in the gastrointestinal tract (GIT), breaking the propagation of lipid peroxides oxidation and production of toxic compounds.
Harvesting re-usable high-level rules for expository dialogue generation (2010)

This paper proposes a method for extracting high-level rules for expository dialogue generation. The rules are extracted from dialogues that have been authored by expert dialogue writers. We examine the rules that can be extracted by this method, focusing on whether different dialogues and authors exhibit different dialogue styles.
Scintillation characteristics of Nd 3+ -doped BaO–Al 2 O 3 –TeO 2 glasses (2021)

Abstract Photoluminescence and scintillation characteristics of Nd 3+ -doped TeO 2 glasses [(15– x )BaO–5Al 2 O 3 –80TeO 2 – x Nd 2 O 3 ( x = 0.1–1.0)] were evaluated. The Nd 3+ -doped TeO 2 glasses exhibited sharp emission peaks originating from the 4f–4f transition of Nd 3+ in photoluminescence. The 0.1% Nd 3+ -doped TeO 2 glass showed the highest quantum yield (about 33%). In addition, 0.1%–1.0% Nd 3+ -doped TeO 2 glasses showed photoluminescence decay time constants in the time range of 128–194 μ s originating from the 4 F 3/2 → 4 I 9/2 transition of Nd 3+ . In scintillation, the 0.1%–1.0% Nd 3+ -doped TeO 2 glasses exhibited sharp scintillation peaks at around 905, 1060, and 1335 nm ascribed to the 4f–4f transitions of Nd 3+ . The 0.5% and 1.0% Nd 3+ -doped TeO 2 glasses exhibited high intensities. The decay times of the Nd 3+ -doped TeO 2 glasses under X-ray were in the time range of 123–174 μ s. Moreover, the Nd 3+ -doped TeO 2 glasses exhibited afterglow levels of about 618–829 ppm.
Magnetic properties of patterned arrays of exchange-biased IrMn/Co square dots (2013)

International audience
Rational Development of Nucleoside Diphosphate Prodrugs: DiPPro-Compounds (2015)

The bio-reversible protection of nucleoside diphosphates is summarized. The design, hydrolytic characteristics, and the antiviral activity of these prodrugs of NDPs are described. In contrast to earlier attempts, the DiPPro-approach [β-(bis(acyloxybenzyl) nucleoside diphosphates)] leads to the successful delivery of the desired nucleoside diphosphates. The stability towards hydrolysis is dependent on the specific acyl moieties in the bis(acyloxybenzyl) unit as well as on the particular nucleoside analogue. Hydrolysis studies in aqueous PBS buffer (pH 7.3), 20 % human plasma in PBS, RPMI-1640 culture medium, and CEM cell extracts were carried out. Contrary to a high chemical and plasma stability, the compounds showed a very low half-life in CEM cell extracts, and efficiently released the nucleoside analogues diphosphates, e.g. of AZT, d4T and BVDU. Two additional types of cycloSal- NDP prodrugs were studied but neither proved to be useful as nucleoside diphosphate prodrugs. In summary, the results led to the development of a new series of non-symmetric nucleoside diphosphate prodrugs that selectively delivered the nucleoside diphosphate in cell extracts.
Beyond Energy-Efficiency (2016)

Computing researchers have long focused on improving energy-e ciency under the implicit assumption that all energy is created equal. Yet, this assumption is actually incorrect: energy's cost and carbon footprint vary substantially over time. As a result, consuming energy ine ciently when it is cheap and clean may sometimes be preferable to consuming it e ciently when it is expensive and dirty. Green datacenters adapt their energy usage to optimize for such variations, as reflected in changing electricity prices or renewable energy output. Thus, we introduce energy-agility as a new metric to evaluate green datacenter applications.
Preclinical evaluation of anti-MET antibodies for immunohistochemical staining. (2014)

11103 Background: The monovalent anti-MET antibody onartuzumab in combination with erlotinib showed clinical benefit in a phase II trial in advanced non-small cell lung cancer (NSCLC); this benefit was limited to MET-positive tumors as determined by immunohistochemistry (IHC) using the CONFIRM anti-total MET rabbit monoclonal antibody (Ventana). The trial results demonstrate the importance of a reliable IHC assay to distinguish MET-positive from MET-negative cancers. Therefore, it is important to gain a pre-clinical understanding of available antibodies that may warrant further investigation. The aim of this study was to evaluate nine anti-MET antibodies for sensitivity and specificity using various standard staining conditions. Methods: All antibodies were evaluated on eight formalin-fixed paraffin-embedded (FFPE) cell lines with known RNA and protein (ELISA) MET expression levels. Antibodies with adequate sensitivity and specificity were then analyzed on a NSCLC tissue microarray (TMA) and on whole sections of NSCLC and gastric adenocarcinoma (GAC) of known MET status. The antibody evaluation included four autostainers (Ventana Benchmark XT, Leica BOND-III, Dako Autostainer Plus and Dako Omnis), 14 antigen retrieval (AR) methods and 7 detection methods. Results: The SP44 and D1C2 antibodies showed staining on cell lines, NSCLC TMA, and large sections of NSCLC and GAC of adequate sensitivity and specificity when used under the following conditions: (1) Ventana Benchmark XT with CC1 standard and CC1 extended AR, (2) Leica BOND-III with ER2 AR, (3)DAKO Autostainer with EnVision FLEX Target High pH AR. All other antibodies and AR/detection methodologies showed inferior staining characteristics due to insufficient sensitivity and/or specificity. Conclusions: SP44 and D1C2 showed staining performance similar in sensitivity and specificity to the CONFIRM anti-Total MET antibody. Additional validation on larger cohorts of clinically annotated tissues is required prior to any clinical application. MET antibodies. Vendor Clone or product # Spring Bioscience SP44 Cell Signaling D1C2 My Biosource 3D4 IBL polyclonal #18321 Santa Cruz N-17; C-12; C-28 Abcam 8F11 R&D Systems polyclonal #AF276
Polyamine metabolism is a central determinant of helper T cell lineage fidelity (2021)

Polyamine synthesis represents one of the most profound metabolic changes during T cell activation, but the biological implications of this are scarcely known. Here, we show that polyamine metabolism is a fundamental process governing the ability of CD4<sup>+</sup> helper T cells (T<sub>H</sub>) to polarize into different functional fates. Deficiency in ornithine decarboxylase, a crucial enzyme for polyamine synthesis, results in a severe failure of CD4<sup>+</sup> T cells to adopt correct subset specification, underscored by ectopic expression of multiple cytokines and lineage-defining transcription factors across T<sub>H</sub> cell subsets. Polyamines control T<sub>H</sub> differentiation by providing substrates for deoxyhypusine synthase, which synthesizes the amino acid hypusine, and mice in which T cells are deficient for hypusine develop severe intestinal inflammatory disease. Polyamine-hypusine deficiency caused widespread epigenetic remodeling driven by alterations in histone acetylation and a re-wired tricarboxylic acid (TCA) cycle. Thus, polyamine metabolism is critical for maintaining the epigenome to focus T<sub>H</sub> cell subset fidelity.
L-type calcium channel β subunit modulates angiotensin II responses in cardiomyocytes (2011)

Angiotensin II regulation of L-type calcium currents in cardiac muscle is controversial and the underlying signaling events are not completely understood. Moreover, the possible role of auxiliary subunit composition of the channels in Angiotensin II modulation of L-type calcium channels has not yet been explored. In this work we study the role of Ca(v)β subunits and the intracellular signaling responsible for L-type calcium current modulation by Angiotensin II. In cardiomyocytes, Angiotensin II exposure induces rapid inhibition of L-type current with a magnitude that is correlated with the rate of current inactivation. Semi-quantitative PCR of cardiomyocytes at different days of culture reveals changes in the Ca(v)β subunits expression pattern that are correlated with the rate of current inactivation and with Angiotensin II effect. Over-expression of individual b subunits in heterologous systems reveals that the magnitude of Angiotensin II inhibition is dependent on the Ca(v)β subunit isoform, with Ca(v)β(1b) containing channels being more strongly regulated. Ca(v)β(2a) containing channels were insensitive to modulation and this effect was partially due to the N-terminal palmitoylation sites of this subunit. Moreover, PLC or diacylglycerol lipase inhibition prevents the Angiotensin II effect on L-type calcium channels, while PKC inhibition with chelerythrine does not, suggesting a role of arachidonic acid in this process. Finally, we show that in intact cardiomyocytes the magnitude of calcium transients on spontaneous beating cells is modulated by Angiotensin II in a Ca(v)β subunit-dependent manner. These data demonstrate that Ca(v)β subunits alter the magnitude of inhibition of L-type current by Angiotensin II.
Design of common environmental information for door closing tasks with various robots (2008)

Structuring methods of ambient intelligence are becoming important issue in robotics field; such ambient intelligence can enable robots to adopt ubiquitous computing technologies by using GPS and the RFID tag, acquire the necessary information for working in offices and houses, and thereby work accordingly. There are two merits in putting information into an environment. Firstly, persons who develop each robot can minimize the installation of knowledge of the objects that the robot may use. The new knowledge of the objects are provided by the manufacturers of the object and the owners, designers, architects, or removers who structure the environment whenever the ambience changes. Secondly, in case of different robots, the same ambient intelligence can handle different kinds of robots. No one needs to customize each robot. Each robot is able to execute tasks using the common ambient intelligence.
Opc‐ and pilus‐dependent interactions of meningococci with human endothelial cells: molecular mechanisms and modulation by surface polysaccharides (1995)

The interplay between four surface‐expressed virulence factors of Neisseria meningitidis (pili, Opc, capsule and lipopolysaccharide (LPS)) in host cell adhesion and invasion was examined using derivatives of a serogroup B strain, MC58, created by mutation (capsule, Opc) and selection of variants. To examine the role of Opc and of additional expression of pili, bacteria lacking the expression of Opa proteins were used. The effects of different LPS structures were examined in variants expressing either sialylated (L3 immunotype) or truncated non‐sialylated (L8 immuno‐type) LPS. Studies showed that (i) pili were essential for meningococcal interactions with host cells in both capsulate and acapsulate bacteria with the sialylated L3 LPS immunotype, (ii) the Opc‐mediated invasion of host cells by piliated and non‐piliated bacteria was observed only in acapsulate organisms with L8 LPS immunotype, and (iii) expression of pili in Opc‐expressing bacteria resulted in increased invasion. Investigations on the mechanisms of cellular invasion indicated that the Opc‐mediated invasion was dependent on the presence of serum in the incubation medium and was mediated by serum proteins with arginine‐glycine‐aspartic acid (RGD) sequence. Cellular invasion in piliated Opc + phenotype also required bridging molecules containing the RGD recognition sequence and appeared to involve the integrin αvβ3 as a target receptor on endothelial cells. These studies extend the previous observations on variants of a serogroup A strain (C751) and show that Opc mediates cellular invasion in distinct meningococcal strains and provide confirmation of its mechanism of action. This is the first investigation that evaluates, using derivatives of a single strain, the interplay between four meningococcal surface virulence factors in host cell invasion.
Oxidative Addition of Ammonia to Form a Stable Monomeric Amido Hydride Complex (2005)

The insertion of an iridium complex into an N-H bond in ammonia leads to a stable monomeric amido hydride complex in solution at room temperature. This reaction advances the transition-metal coordination chemistry of ammonia beyond its role for more than a century as an ancillary ligand. The precursor for this insertion reaction is an iridium(I) olefin complex with an aliphatic ligand containing one carbon and two phosphorus donor atoms. Kinetic and isotopic labeling studies indicate that olefin dissociates to give a 14-electron iridium(I) fragment, which then reacts with ammonia. This cleavage of the N-H bond under neutral conditions provides a foundation on which to develop future mild catalytic transformations of ammonia, such as olefin hydroamination and arene oxidative amination.
Laser fluorescence study of AlO formed in the reaction Al + O2: Product state distribution, dissociation energy, and radiative lifetime (1975)

The reaction Al + O2 → AlO + O has been investigated by the method of laser−induced fluorescence. Excitation spectra are reported for AlO products formed under single−collision conditions in a ’’beam−gas’’ arrangement. The relative vibrational populations (proportional to total cross sections for formation), as well as the relative rotational populations for the v = 0 and v = 1 vibrational levels, are derived. The rotational distributions are found to differ significantly, with v = 0 having more rotational excitation than v = 1. The vibrational distribution is non−Boltzmann, the falloff with v ≳ 1 exceeding v = 1 compared to v = 0. The observed internal state distributions are compared with those calculated from phase space theory. It is concluded tentatively that the partitioning of the Al + O2 reaction energy among the product modes is not governed solely by statistical considerations. The dynamics of the Al + O2 reaction are compared with those of the exothermic Ba + O2 and endothermic K + O2 reactions. From a knowledge of the AlO internal states populated by the Al + O2 reaction and from an estimate of the thermal reactant energies, a lower bound for the ground state dissociation energy of AlO is derived. By combining the present lower bound with the upper bound previously derived from observation of the onset of an AlO absorption continuum, the value D00(AlO) = 121.5±1 kcal/mole is recommended for aluminum monoxide. Direct measurement of the fluorescence decay of the AlO B 2Σ+ state as a function of time after excitation by the short (∼5 nsec) laser pulse has allowed the determination of the radiative lifetimes τ (v′ = 0) = 100±7 nsec, τ (v′ = 1) = 102±7 nsec, and τ (v′ = 2) = 102±4 nsec, where the error estimates represent three standard deviations.
A method for predicting the field in permanent-magnetic axial-field motors (1992)

A method for analyzing the field in the coil region of permanent-magnet axial-field motors is presented. The method entails the use of a theoretically derived two-dimensional field formula coupled with a semiempirical procedure for specifying the magnetic state of the motor magnet. This method enables rapid parametric studies of field strength relative to variations in motor dimensions and magnet materials. It is applied to a motor with a ceramic magnet, and excellent agreement is demonstrated between the computed and measured data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
POST-ACUTE SEQUELAE AND ADAPTIVE IMMUNE RESPONSES IN PEOPLE LIVING WITH HIV RECOVERING FROM SARS-COV-2 INFECTION (2022)

ABSTRACT Background Limited data are available on the long-term clinical and immunologic consequences of SARS-CoV-2 infection in people with HIV (PWH). Methods We measured SARS-CoV-2 specific humoral and cellular responses in people with and without HIV recovering from COVID-19 (n=39 and n=43, respectively) using binding antibody, surrogate virus neutralization, intracellular cytokine staining, and inflammatory marker assays. We identified individuals experiencing post-acute sequelae of SARS-CoV-2 infection (PASC) and evaluated immunologic parameters. We used linear regression and generalized linear models to examine differences by HIV status in the magnitude of inflammatory and virus-specific antibody and T cell responses, as well as differences in the prevalence of PASC. Results Among PWH, we found broadly similar SARS-CoV-2-specific antibody and T cell responses as compared with a well-matched group of HIV-negative individuals. PWH had 70% lower relative levels of SARS-CoV-2 specific memory CD8+ T cells (p=0.007) and 53% higher relative levels of PD-1+ SARS-CoV-2 specific CD4+ T cells (p=0.007). Higher CD4/CD8 ratio was associated with lower PD-1 expression on SARS-CoV-2 specific CD8+ T cells (0.34-fold effect, p=0.02). HIV status was strongly associated with PASC (odds ratio 4.01, p=0.008), and levels of certain inflammatory markers (IL-6, TNF-alpha, and IP-10) were associated with persistent symptoms. Conclusions We identified potentially important differences in SARS-CoV-2 specific CD4+ and CD8+ T cells in PWH and HIV-negative participants that might have implications for long-term immunity conferred by natural infection. HIV status strongly predicted the presence of PASC. Larger and more detailed studies of PASC in PWH are urgently needed.
Exchange of Ions across the TiN/TaOx Interface during Electroformation of TaOx-Based Resistive Switching Devices (2020)

The valence change model describes the resistive switching in metal oxide-based devices as due to electroreduction of the oxide and subsequent electromigration of oxygen vacancies. Here, we present cross-sectional X-ray energy-dispersive spectroscopy elemental maps of Ta, O, N, and Ti in electroformed TiN/TaO<sub>2.0</sub>/TiN structures. O, N, and Ti were exchanged between the anode and the functional oxide in devices formed at high power (∼1 mW), but the exchange was below the detection limit at low power (<0.5 mW). All structures exhibit a similar Ta-enriched and O-depleted filament formed by the elemental segregation in the functional oxide by the temperature gradient. The elemental interchange is interpreted as due to Fick's diffusion caused by high temperatures in the gap of the filament and is not an essential part of electroformation.
Identification of Subgroups with Favorable Prognosis in Breast Cancer (1992)

The prognostic significance of 16 factors was investigated in a series of 311 women with unilateral, invasive breast carcinoma without distant metastases (M0) and treated with mastectomy. The series consisted of 93% of such cases diagnosed histologically in the city of Turku, Finland, from 1980 to 1984. Mitotic count, histological and nuclear grades, extent of tumor necrosis, axillary nodal status (pN), tumor size (pT), estrogen and progesterone receptor (PR) contents, and S-phase fraction were the most powerful single factors (p = 0.0001 or less). Axillary node negative cancers with no or only spotty tumor necrosis (92% of all pN0 cases) were associated with a 96% 5-year survival rate corrected for intercurrent causes. Among the axillary node positive cases the combination of high PR content (greater than 60 fmol/mg protein) and a low mitotic count could identify a subgroup with a 96% 5-year corrected survival rate (25% of all pN+ cases). It is concluded that both pN0 and pN+ breast cancer contain identifiable subgroups with greatly different prognosis.
Cyclic liquid-jet behavior in pulsating bubbles (1975)

Motion pictures will be shown of liquid jets that develop in air bubbles pulsating at 60 Hz and redevelop in each cycle. The air bubbles grow by rectified diffusion from nuclei present in a glycerin-water mixture to sizes on the order of a few millimeters, and are then trapped on a platform situated within the resonator. The resonator consists of an aluminum cylinder, with heavy glass end windows, that is oscillated at 60 Hz by a vibration platform. The ambient pressure above the liquid is reduced to near that of the vapor pressure, which allows the resonator to generate large pulsation amplitudes in the air bubbles at low driving amplitudes. The pictures to be shown were made in two different ways. The first was made with a high-speed Fastax camera running at approximately 4000 frames/sec with bright field illumination. The second was made with bright field illumination from a high-intensity strobe that was driven near the oscillation frequency of the resonator. [Work supported by the Naval Academy Research Council and the Office of Naval Research.]
Managing the intelligent enterprise (2004)

Over the last few years, we have seen the transformation of the traditional monolithic enterprise, in which all operations were performed in-house, to the extended enterprise, which consists of a network of collaborating entities. Global operations, outsourcing, and increasing specialization have all contributed to this trend. One challenge facing the extended enterprise is how to reconnect the information flows and business processes that were disconnected as the enterprise disaggregated. The emergence of web services, service-oriented architectures, and business process modeling and execution standards are helping to address this challenge. Our contention is that the next phase of evolution is the rise of the intelligent enterprise, which is characterized by being able to adapt quickly to changes in its operating environment. The intelligent enterprise monitors its own business processes and its interactions with customers, partners, suppliers, and collaborators; it understands how this information relates to its business objectives; and it acts to control and optimize its operations to meet its business objectives. Decisions are made quickly and accurately to modify business processes on the fly, dynamically allocate resources, or change business partners (e.g., suppliers, service providers) and partnerships (e.g., establish new service level agreements). This talk will describe challenges in managing the business operations of an intelligent enterprise. While a plethora of tools exist for managing the IT infrastructure (servers, storage, and network resources) of the enterprise, there is little systematic support today for the closed loop management and control of business operations. We will describe technology approaches to intelligent business operations management that we are pursuing at HP Labs., the progress we have made, and some open research questions.