gebhart/patrepeval huggingface dataset:
Allosteric Interactions between the Two Non-equivalent Nucleotide Binding Domains of Multidrug Resistance Protein MRP1 (2000)

Membrane transporters of the adenine nucleotide binding cassette (ABC) superfamily utilize two either identical or homologous nucleotide binding domains (NBDs). Although the hydrolysis of ATP by these domains is believed to drive transport of solute, it is unknown why two rather than a single NBD is required. In the well studied P-glycoprotein multidrug transporter, the two appear to be functionally equivalent, and a strongly supported model proposes that ATP hydrolysis occurs alternately at each NBD (Senior, A. E., al-Shawi, M. K., and Urbatsch, I. L. (1995) FEBS Lett 377, 285-289). To assess how applicable this model may be to other ABC transporters, we have examined adenine nucleotide interactions with the multidrug resistance protein, MRP1, a member of a different ABC family that transports conjugated organic anions and in which sequences of the two NBDs are much less similar than in P-glycoprotein. Photoaffinity labeling experiments with 8-azido-ATP, which strongly supports transport revealed ATP binding exclusively at NBD1 and ADP trapping predominantly at NBD2. Despite this apparent asymmetry in the two domains, they are entirely interdependent as substitution of key lysine residues in the Walker A motif of either impaired both ATP binding and ADP trapping. Furthermore, the interaction of ADP at NBD2 appears to allosterically enhance the binding of ATP at NBD1. Glutathione, which supports drug transport by the protein, does not enhance ATP binding but stimulates the trapping of ADP. Thus MRP1 may employ a more complex mechanism of coupling ATP utilization to the export of agents from cells than P-glycoprotein.
Complexity reduced behavioural modeling of dynamic nonlinear power amplifiers using two‐box structures (2016)

ABSTRACT This paper addresses the problem of model size estimation in power amplifiers behavioural modeling and predistortion applications using multi‐basis functions memory polynomials. A low complexity sequential approach is proposed along with a suitable model. The proposed model and size estimation approach are experimentally assessed for the modeling and predistortion of an LTE envelope‐tracking power amplifier. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:726–732, 2016
Hand-foot-syndrome is associated with improved survival in patients treated with sorafenib for hepatocellular carcinoma (2015)

Hepatocellular carcinoma (HCC) is a frequent complication of chronic liver diseases and a leading cause of cancer related deaths. Systemic treatments for HCC like sorafenib might be limited by toxicity and impaired liver function. Clear parameters predicting to the response to sorafenib therapy are sparse.
ChemInform Abstract: Unprecedented Selectivity in the Reaction of 1,2:5,6‐Dianhydro‐3,4‐O‐ Isopropylidenehexitols with Benzylamine: A Practical Synthesis of 3,4, 5,6‐Tetrahydroxyazepanes. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
CONGENITAL T CELL DEFICIENCY WITH NEUTROPENIA AND ERYTHROBLASTOPENIA (1985)

PERREAULT, CLAUDE; BONNY, YVETTE; GYGER, MARTIN; BELANGER, ROBERT; ROBITAILLE, DANIELLE; BOILEAU, JACQUES; DAVID, MICHELE; D'ANGELO, GIOVANNI; BLANCHARD, LYSANE; CHARRON, MARTHE Author Information
Evidence generation and reproducibility in cell and gene therapy research: A call to action (2021)

Editorial
Coherent Combining of Pulsed Fiber Amplifiers in the Nonlinear Chirp Regime (2012)

Two tapered fiber amplifier chains were coherently combined to generate 0.42-mJ, 1-ns pulses with 79% efficiency despite 38 radians of intra-pulse phase distortion. A recursive real-time chirp control method significantly reduced these phase errors.
Total Synthesis and Structure–Activity Relationship Studies of the Cytotoxic Anhydrophytosphingosine Jaspine B (Pachastrissamine) (2016)

By utilizing an <sc>l</sc>-serine-derived bicyclic lactone as an advanced chiral building block, a short synthetic route to the cytotoxic marine natural product jaspine B has been developed. Targeting structure–activity relationship investigations, the synthetic route has also been utilized for the synthesis and cytotoxicity evaluation of strategically modified jaspine B analogues. In addition, a previously reported synthesis of the title natural product from our research has been reinvestigated to clarify the sterochemical assignment.
A maintenance-focused approach to complex system design (2016)

Abstract Maintenance plays a critical role in reducing operating cost and maximizing reliability of a complex engineering system. This paper proposes a novel maintenance-focused, system-level design framework that attempts to capture the interactions between maintenance strategies and system-level design parameters overlooked in current modeling approaches. The goal of this maintenance-focused approach is to help designers better understand the interconnectedness of system architecture, choice of maintenance strategy, and uncertainties in a design. Application of the proposed design framework is demonstrated through a case example of a power plant condenser system. Results show that using an integrated approach can reveal the many nonobvious interactions between subsystems, and produce system designs that have lower life-cycle cost compared to traditional sequential design approaches.
Evidence accumulation determines conscious access (2020)

A fundamental scientific question concerns the neuronal basis of perceptual consciousness, which encompasses the perceptual experience and reflexive monitoring associated with a sensory event. Although recent human studies identified individual neurons reflecting stimulus visibility, their functional role for perceptual consciousness remains unknown. Here, we provide neuronal and computational evidence indicating that perceptual and reflexive consciousness are governed by an all-or-none process involving accumulation of perceptual evidence. We recorded single-neuron activity in a participant with a microelectrode implant in the posterior parietal cortex, considered a substrate for evidence accumulation, while he detected vibrotactile stimuli around detection threshold and provided confidence estimates. We found that detected stimuli elicited firing rate patterns resembling evidence accumulation during decision-making, irrespective of response effectors. Similar neurons encoded the intensity of task-irrelevant stimuli, suggesting their role for consciousness per se, irrespective of report. We generalized these findings in healthy volunteers using electroencephalography and reproduced their behavioral and neural responses with a computational model. This model considered stimulus detection if accumulated evidence reached a bound, and confidence as the distance between maximal evidence and that bound. Applying this mechanism to our neuronal data, we were able to decode single-trial confidence ratings both for detected and undetected stimuli. Our results show that the specific gradual changes in neuronal dynamics during evidence accumulation govern perceptual consciousness and reflexive monitoring in humans.
A Bi-directional Hierarchical Clustering (BHC) for Peak Matching of Large Mass Spectrometry Data Sets (2021)

the preprocessing of mass spectrometry (MS) data is a crucial step in every MS study, which not only makes data comparable and manageable but also makes the study more reproducible. However, an essential part of this process, which is often overlooked, is peak matching. Although existing clustering methods have been applied for peak matching, the use of these methods have been limited. For example, the use of hierarchical agglomerative clustering (HAC) for matching of mass/charge signals has been constrained to small-scale MS data sets due to the computational complexity of HAC. In this paper, we reintroduce a bi-directional hierarchical agglomerative clustering (BHC) as a scalable and accurate peak matching technique. As a result, the computational complexity of hierarchical agglomerative clustering for peak matching was optimized by BHC to O(RlogR). BHC was benchmarked against existing peak matching techniques. Finally, we propose a parallelization framework that significantly reduces the peak matching method's computation time.
Differentiating Digital Printing Through Physical and Chemical Analyses (2020)

Over the past decade, the trade of counterfeit goods has increased. This has been enabled by advancements in low-cost digital printing methods (e.g., inkjet and laserjet) that are an asset for counterfeit production methods. However, each printing method produces characteristic printed features that can be used to identify not only the printing method, but also, uniquely identify the specific make and model of printer. This knowledge can be used for determination of whether or not the analyzed item is counterfeit. During the first phase of this research, chemical and physical analyses were performed on printed documents and ink samples for two types of digital printing: inkjet and laserjet. The results showed that it is possible to identify the digital method used to print a document by its unique features. Physical analysis revealed that the laserjet prints have a higher image quality characterized by sharper feature edge quality, brighter image area, and a thicker ink layer (10 micron average thickness) than in inkjet documents. Chemical analysis showed that the inkjet and laserjet inks could easily be distinguished by identifying the various ink components. Ink jet inks included (among others) water, ethylene glycol while laserjet inks presented styrene, methacrylate, and sulfide compounds.
Laser-induced damage of fused silica at 355 nm initiated at scratches (1998)

Scratches of measured width were produced on the surface of a IV grade fused silica window using a diamond tip. Two scratch morphologies were observed: plastic and brittle. The scratches were irradiated with a 355 nm laser pulse. The laser-induced damage threshold (LIDT) of the unscratched output surface was 15 J/cm<SUP>2</SUP> at 3-ns. The LIDT of the scratched surface as a function of scratch width was then measured for both input and output surface scratches. Input surface scratches of width smaller than 10 micrometers did not influence the LIDT of the silica window. On the output surface, 7 $mUm wide scratches lowered the LIDT by a factor of two. For larger scratches, the LIDT reached an asymptotic value of 5 J/cm<SUP>2</SUP> on both input and output surface. Possible reasons for this LIDT drop could be electric field enhancement in the cracks below the scratch, the presence of contamination particles in the scratch, or the weakening of the material because of existing mechanical flaws.
Potent Triazolothione Inhibitor of Heat‐Shock Protein‐90 (2009)

Heat-shock protein-90 is an attractive target for anticancer drugs, as heat-shock protein-90 blockers such as the ansamycin 17-(allylamino)-17-demethoxygeldanamycin greatly reduce the expression of many signaling molecules that are disregulated in cancer cells and are key drivers of tumor growth and metastasis. While 17-(allylamino)-17-demethoxygeldanamycin has shown promise in clinical trials, this compound class has significant template-related drawbacks. In this paper, we describe a new, potent non-ansamycin small-molecule inhibitor of heat-shock protein-90, BX-2819, containing resorcinol and triazolothione rings. Structural studies demonstrate binding of BX-2819 to the ADP/ATP-binding pocket of heat-shock protein-90. The compound blocked expression of heat-shock protein-90 client proteins in cancer cell lines and inhibited cell growth with a potency similar to 17-(allylamino)-17-demethoxygeldanamycin. In a panel of four cancer cell lines, BX-2819 blocked growth with an average IC(50) value of 32 nM (range of 7-72 nM). Efficacy studies demonstrated that treatment with BX-2819 significantly inhibited the growth of NCI-N87 and HT-29 tumors in nude mice, consistent with pharmacodynamic studies showing inhibition of heat-shock protein-90 client protein expression in tumors for greater than 16 h after dosing. These data support further studies to assess the potential of BX-2819 and related analogs for the treatment of cancer.
Brownian Dynamics Simulations of Magnetic Nanoparticles Captured in Strong Magnetic Field Gradients (2016)

The behavior of spherical single-domain magnetic nanoparticles in strong inhomogeneous magnetic fields is investigated through Brownian dynamics simulations, taking into account magnetic dipole–dipole interactions, repulsive hard-core Yukawa potential, hydrodynamic particle-wall interactions, and the mechanism of magnetic dipole rotation in the presence of a magnetic field. The magnetic capture process of nanoparticles in prototypical magnetic field gradients generated by a sudden reversal in perpendicular magnetization of a flat substrate (defining a “capture line”) is studied as a function of strength of the magnetic field and volume fraction of the magnetic nanoparticles. Capture curves show a regime where capture follows a power law model and suggest that particles with the Brownian relaxation mechanism are captured at a slightly faster rate than particles with the Néel relaxation mechanism under similar conditions of the field gradient. Additionally, evaluation of the shape of the aggregates of captured particles suggests that greater dipole–dipole interactions result in aggregate structures that are flatter/wider than in the case of negligible dipole–dipole interactions. These results can help guide the design of systems for magnetically directed assembly of nanoparticles into complex shapes at a substrate.
Randomized Summer Camp Crossover Trial in 5- to 9-Year-Old Children: Outpatient Wearable Artificial Pancreas Is Feasible and Safe (2016)

This trial, the first outpatient single-hormone AP trial in a population of this age, shows feasibility and safety of MMPC in young children. Algorithm retuning will be performed to improve efficacy.
Perturbative approach to non-Markovian stochastic Schrödinger equations (2002)

In this paper we present a perturbative procedure that allows one to numerically solve diffusive non-Markovian stochastic Schr\"odinger equations, for a wide range of memory functions. To illustrate this procedure numerical results are presented for a classically driven two-level atom immersed in an environment with a simple memory function. It is observed that as the order of the perturbation is increased the numerical results for the ensemble average state ${\ensuremath{\rho}}_{\mathrm{red}}(t)$ approach the exact reduced state found via $\mathrm{Imamo}\mathrm{g}\ifmmode\bar\else\textasciimacron\fi{}{\mathrm{lu}}^{\ensuremath{'}}\mathrm{s}$ enlarged system method [Phys. Rev. A 50, 3650 (1994)].
Radiometric Performance of the SMOS Reference Radiometers—Assessment After One Year of Operation (2012)

In this paper, we present an analysis of the radiometric performance of the three 1.4-GHz noise injection radiometers of the European Space Agency's Soil Moisture and Ocean Salinity (SMOS) satellite. The units measure the antenna temperature, which contributes to the average brightness temperature level of SMOS retrievals. We assess the radiometric resolution of the receivers, the similarity between their measurements, and their thermal stability. For these purposes, we use SMOS measurement data gathered during the first year of the orbital operations of the satellite, which was launched in November 2009. The main results from the analysis are that the units meet the design requirements with a margin. Also, we present a new thermal model for the radiometers to further enhance their stability.
A Novel Catechol-Based Universal Support for Oligonucleotide Synthesis (2007)

A novel universal support for deoxyribo- and ribonucleic acid synthesis has been developed. The support, constructed from 1,4-dimethoxycatechol, represents an improvement over existing universal supports because of its ability to cleave and deprotect under mild conditions in standard reagents. Because no nonvolatile additives are required for cleavage and deprotection, the synthesized oligonucleotides do not require purification prior to use in biochemical assays. Using reverse phase HPLC and electrospray mass spectroscopy, it was determined that oligonucleotides synthesized on the universal support (UL1) 3'-dephosphorylate quickly (9 h in 28-30% ammonium hydroxide (NH4OH) at 55 degrees C, 2 h in 28-30% NH4OH at 80 degrees C, or <1 h in ammonium hydroxide/methylamine (1:1) (AMA) at 80 degrees C). Oligonucleotides used as primers for the polymerase chain reaction (PCR) assay were found to perform identically to control primers, demonstrating full biological compatibility. In addition, a method was developed for sintering the universal support directly into a filter plug which can be pressure fit into the synthesis column of a commercial synthesizer. The universal support plugs allow the synthesis of high-quality oligonucleotides at least 120 nucleotides in length, with purity comparable to non-universal commercial supports and approximately 50% lower reagent consumption. The universal support plugs are routinely used to synthesize deoxyribo-, ribo-, 3'-modified, 5'-modified, and thioated oligonucleotides. The flexibility of the universal support and the efficiency of 3'-dephosphorylation are expected to increase the use of universal supports in oligonucleotide synthesis.
The dispersed fluorescence spectrum of NaAr: Ground and excited state potential curves (1979)

The van der Waals molecule NaAr has been prepared by supersonic free jet expansion of a mixture of sodium, argon, and helium. The A 2Π←X 2Σ+ electronic transition has been excited by a tunable dye laser and the resulting A→X fluorescence has been studied. The dispersed fluorescence spectra display both discrete and diffuse features, corresponding to transitions from excited vibrational levels of the A state to bound and unbound levels of the X state. The characteristic reflection structure in the bound-free spectra permits an unambiguous assignment of the vibrational numbering in the A state. This assignment and the previously measured spectroscopic constants are used to calculate the potential curve of the A state. The discrete structure in the fluorescence spectra is analyzed and, together with the previous measurements, is used to determine the potential curve of the X state in the well region. The repulsive part of the X curve is then deduced through trial-and-error simulation of the biund-free spectra. The potential curves derived in this work are compared critically with results of several previous experimental and theoretical studies of NaAr.
ChemInform Abstract: Cyclization Reactions of 2,3‐Bis(phenylsulfonyl)‐1,3‐butadiene with Various Carbanions. A (4 + 1) Anionic Annulation Approach to Phenylsulfonyl‐Substituted Cyclopentenes. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Load-balanced architecture for dynamic traffic (2005)

We present a novel and practical scheme for carrying dynamic data traffic over circuits at lower costs than existing architectures. We demonstrate its effectiveness in handling burstiness as well as long-term variations in traffic patterns.
Updating Thermodynamic Model for the Waste Isolation Pilot Plant (WIPP). (2015)

Abstract not provided.
High-Performance Motor Drives (2011)

This article reviews the present state and trends in the development of key parts of controlled induction motor drive systems: converter topologies, modulation methods, as well as control and estimation techniques. Two- and multilevel voltage-source converters, current-source converters, and direct converters are described. The main part of all the produced electric energy is used to feed electric motors, and the conversion of electrical power into mechanical power involves motors ranges from less than 1 W up to several dozen megawatts.
Search for massive WH resonances decaying into the $$\ell \nu \mathrm{b} \overline{\mathrm{b}} $$ ℓ ν b b ¯ final state at $$\sqrt{s}=8$$ s = 8 $$~\text {TeV}$$ TeV (2016)

A search for a massive resonance [Formula: see text]decaying into a W and a Higgs boson in the [Formula: see text] ([Formula: see text], [Formula: see text]) final state is presented. Results are based on data corresponding to an integrated luminosity of 19.7[Formula: see text] of proton-proton collisions at [Formula: see text] [Formula: see text], collected using the CMS detector at the LHC. For a high-mass ([Formula: see text]1[Formula: see text]) resonance, the two bottom quarks coming from the Higgs boson decay are reconstructed as a single jet, which can be tagged by placing requirements on its substructure and flavour. Exclusion limits at 95 % confidence level are set on the production cross section of a narrow resonance decaying into WH, as a function of its mass. In the context of a little Higgs model, a lower limit on the [Formula: see text] mass of 1.4[Formula: see text] is set. In a heavy vector triplet model that mimics the properties of composite Higgs models, a lower limit on the [Formula: see text] mass of 1.5[Formula: see text] is set. In the context of this model, the results are combined with related searches to obtain a lower limit on the [Formula: see text] mass of 1.8[Formula: see text], the most restrictive to date for decays to a pair of standard model bosons.
One-transistor bistable-body tunnel SRAM (2009)

A one-transistor tunnel SRAM cell is proposed and analyzed. The new cell uses the bistability of a tunnel diode pair to latch the body voltage of a MOSFET which then shifts the threshold voltage and enables sensing of the state by measurement of the MOS transistor current. Band-to-band tunneling is used to write the cell.
Supplementary File 5 from Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism Arrays (2023)

Supplementary File 5 from Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism Arrays
High Rates of Cross-pollination in Chile Pepper (1984)

Abstract The natural cross-pollination (NCP) rate was determined for chile pepper ( Capsicum annuum L.) utilizing isozyme variation in tester lines. Experiments were conducted over a 2 year period in a total of 5 commercial fields in southern New Mexico. The average NCP for both years was 42% with the rate for individual plants as high as 91%. Such high rates of cross-pollination indicate the need for the strictest precautions in the production of commercial seed, and in the design and execution of breeding procedures.