gebhart/patrepeval huggingface dataset:
Four-dimensional photonic micro-actuators for microfluidics applications (2020)

With the advent of two-photon polymerization direct laser writing (TPP-DLW) the generation of high resolution three-dimensional (3D) microstructures with arbitrary shapes has increased dramatically. However, the fabrication of stimuli-responsive photoresists, essentially creating four-dimensional (4D) microstructures, remains a significant challenge. Herein, we present a supramolecular cholesteric liquid crystalline (CLC) photonic-photoresist for the fabrication of 4D photonic micro-actuators with sub-micron resolution. These structures display structural color and shape changes which are triggered by variation of humidity and/or temperature. These results embody the advantages of merging self-ordering systems with TPP-DLW to fabricate novel dual-responsive microstructures which hold potential for the development of micro-robots or as sensing elements in microfluidic devices.
A voice enabled procedure browser for the International Space Station (2005)

Clarissa, an experimental voice enabled procedure browser that has recently been deployed on the International Space Station (ISS), is to the best of our knowledge the first spoken dialog system in space. This paper gives background on the system and the ISS procedures, then discusses the research developed to address three key problems: grammar-based speech recognition using the Regulus toolkit; SVM based methods for open microphone speech recognition; and robust side-effect free dialogue management for handling undos, corrections and confirmations.
Treatment of the Mayer–Rokitansky–Küster–Hauser syndrome with autologous in vitro cultured vaginal tissue: descriptive study of long‐term results and patient outcomes (2018)

Vaginoplasty using in vitro vaginal tissue ensures a satisfactory sexual function and improves quality of life.
Lithium Speciation in the LiPF6/PC Electrolyte Studied by Two-Dimensional Heteronuclear Overhauser Enhancement and Pulse-Field Gradient Diffusometry NMR (2019)

Electrolytic dissociation of lithium hexafluorophosphate (LiPF6) in the nonaqueous cyclic propylene carbonate (PC) has been investigated in the wide range of concentration (0.05–3.5 M) by 7Li solution-state nuclear magnetic resonance (NMR) spectroscopy. Two-dimensional heteronuclear Overhauser enhancement spectroscopy NMR experiments have not only enabled the cation solvation and ion-pairing to be directly monitored but additionally evidence anion–solvent interaction at higher concentrations (>1.2 M) of the PC electrolyte. Preliminary analysis of kinetic nOe data has been made to determine site-dependent cross-relaxation rates for the spatial interaction of the solvent with the Li+ cation and the PF6– anion. The concentration dependence of the 7Li NMR self-diffusion coefficient (Dself), determined using very strong pulsed magnetic field gradients (∼1700 Gauss/cm), depicts two breaks to mark the solvation and ion-pairing events in a distinct manner. This in turn has aided the determination of solvent coordination number and average sizes of solvated and ion-paired clusters. Our results indicate that in the contact ion pair (CIP)-dominated electrolyte (>2 M), lithium-ion mobility across the solvated and ion-paired environments appears to be inhibited which makes the spectral distinction of solvated and ion-paired environments possible. The concentration dependence of the 7Li NMR spectral and diffusometry data is in striking correspondence with that of bulk conductivity measurements and point to the detrimental effect of CIP aggregates in impeding the ionic conductivity at high salt concentrations. These results have significance in understanding the structure and dynamics of lithium-ion solvates that are ubiquitous in the working environment of a lithium-ion battery.
Transformed hairy roots of Mesembryantemum crystallinum: gene expression patterns upon salt stress (1994)

In Mesembryanthemum crystallinum L. (common ice plant), salinity initiates a series of events that contribute to increases in osmotically active metabolites and the establishment of water conserving Crassulacean Acid Metabolism. To better understand the role of isolated root‐specific responses during salt stress, a vigorously growing root culture was needed. Thus, we took advantage of the ability of Agrobacterium rhizogenes to transform and generate growing hairy roots. Treatment of the morphologically similar hairy and nontransformed roots of whole plants with 400 m M NaCl caused an 8‐fold increase in proline levels in these tissues. A heat shock protein 70 cognate, isolated from a root specific cDNA library, was also present at simlar levels in unstressed and stressed samples of both types of roots. However, the steady state abundance of 6 other root cDNAs differed dramatically between transformed hairy and normal roots in response to salt stress. These observations suggest that several responses to salt stress are conserved between roots of whole plants and hairy roots. Additionally, a portion of transcripts reacting to salt stress may be modulated by other factors exclusive to A. rhizogenes transformed hairy root growth. The complex and hierarchical environmental stress response of this halophyte relies on several tissue‐specific interactions, and these responses are most accurately characterized in whole plant tissues.
Spectral efficiency of the multipair two-way relay channel with massive arrays (2013)

We consider a multipair two-way relay channel where multiple communication pairs share the same time-frequency resource and a common relay node. We assume that all users have a single antenna, while the relay node is equipped with a very large antenna array. We consider two transmission schemes: (I) separate-training zero-forcing (ZF) and (II) a new proposed coupled-training ZF. For both schemes, the channels are estimated at the relay by using training sequences, assuming time-division duplex operation. The relay processes the received signals using ZF. With the separate-training ZF, the channels from all users are estimated separately. By contrast, with the coupledtraining ZF, the relay estimates the sum of the channels from two users of a given communication pair. This reduces the amount of resources spent in the training phase. Self-interference reduction is also proposed for these schemes. When the number of relay antennas grows large, the effects of interpair interference and self-interference can be neglected. The transmit power of each user and of the relay can be made inversely proportional to the square root of the number of relay antennas while maintaining a given quality-of-service. We derive a lower bound on the capacity which enables us to evaluate the spectral efficiency. The coupled-training ZF scheme is preferable for the high-mobility environment, while the separate-training ZF scheme is preferable for the low-mobility environment.
Abstract 1693: ASN004, a novel 5T4-targeted Dolaflexin™ antibody drug conjugate, causes complete regression in multiple solid tumor models (2015)

Abstract ASN004 is an Antibody Drug Conjugate (ADC) that targets the 5T4 oncofetal antigen (trophoblast glycoprotein), which is highly expressed in a wide range of malignant tumors, while having very limited expression in normal tissues. ASN004 incorporates a novel single-chain homo-dimer antibody, Fleximer® linker technology (Mersana Therapeutics), and several cytotoxic dolastatin (auristatin) analog warheads per ADC molecule (drug/antibody ratio ∼15). ASN004 shows high affinity for the 5T4 antigen and for 5T4-expressing tumor cells. As well, ASN004 shows potent cytotoxicity that is selective for 5T4-expressing tumor cells. ASN004 provides strong tumor regression and tumor-free survivors in multiple tumor xenograft models, at well-tolerated doses as low as 0.3 mg/kg iv. Furthermore, ASN004 causes tumor regression when administered to xenografts bearing more advanced (500 mm3) tumors. Robust, potent efficacy for ASN004 has also been demonstrated in head-to-head comparison studies with relevant reference ADCs. A favorable pharmacokinetics profile was observed in rodents and primates. Dose-range finding exploratory toxicology studies have been completed in both pharmacological and non-pharmacological non-clinical species. Efforts toward IND-enabling safety studies with this promising new agent are in progress. Citation Format: Roger A. Smith, Nitin K. Damle, Sanjeeva P. Reddy, Alex Yurkovetskiy, Natalya Bodyak, Mao Yin, Dmitry Gumerov, Elena Ter-Ovanesyan, Liu Qin, Peter U. Park, Timothy B. Lowinger, Sandeep Gupta. ASN004, a novel 5T4-targeted Dolaflexin™ antibody drug conjugate, causes complete regression in multiple solid tumor models. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1693. doi:10.1158/1538-7445.AM2015-1693
<title>Direct-view autostereoscopic monitor without goggles</title> (1997)

Physical Optics Corporation has developed an autostereoscopic 3D display system that does not require viewers to wear goggles. This system is based on a stationary holographic projection diffuser fabricated using volume multiphase holographic optical elements. Design and development of the prototype are also described.
Normal Glucose Tolerance with a High 1-Hour Postload Plasma Glucose Level Exhibits Decreased β-Cell Function Similar to Impaired Glucose Tolerance (2015)

Among Korean subjects with NGT, those who have a higher 1-hour postload glucose level have a compromised insulin-sensitivity adjusted β-cell function to a similar degree as IGT subjects.
ChemInform Abstract: Stereospecificity in the Pictet‐Spengler Reaction. Kinetic vs Thermodynamic Control. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A New Sensing and Digital-Conversion Scheme With Adaptive Image-Quality Adjustment for A Fingerprint Sensor Chip (2002)

A new fingerprint sensing and digital-conversion scheme is proposed. In this scheme, transforming the sensed signal to a time axis widens the dynamic range of the signal, and the transformed signal is converted to the digital signal with variable range and offset. These features make it possible to sense various fingerprints clearly. We also propose a flow that adjusts the quality of the fingerprint image adaptively. The effectiveness of the scheme on sensing fingerprints clearly was confirmed by a test chip fabricated using 0.5-/spl mu/m CMOS/sensor process. This scheme assists in precise user identification for a safe and comfortable networked world.
1322: Total Number of Lymph Nodes Removed, Number of Positive Nodes, and Lymph Node Density do not Correlate with Recurrence or Survival in Node-Positive Bladder Cancer (2005)

indicated. Patients with local pelvic recurrence had a higher percentage of lymphovascular invasion on initial cystectomy than the other recurrence site groups.
Long-term monitoring of cable stays with a wireless sensor network (2009)

Wireless sensor networks (WSNs) are a promising technology that could induce a significant innovation in the field of structural monitoring. The main advantages of WSNs are fast deployment, little interference and self-organisation. However, since WSN are battery powered, the power management of the sensor nodes significantly influences the operation method and the overall data management process. Since data communication is the most energy-consuming task, a significant data reduction has to be attained in the sensor nodes to achieve system lifetimes that are useful for real life applications. This paper discusses several basic aspects of data processing and data management for long-term monitoring with WSNs. It presents a specific monitoring system and illustrates a long-term field test performed with this system on a bridge. The test results demonstrate that in-network data reduction is a very promising but challenging approach, since it has to be implemented with very limited computational and memory resources.
Ion Exchange Chromatographic Behavior of a Homologous Cytochrome C Variant Library Obtained by Controlled Succinylation (2010)

A cytochrome C homologous library with varying charge distribution was employed to study the effects of protein surface modification on protein retention in cation exchange chromatography. Varying quantities of succinic anhydride were added to horse cytochrome c to control the degree of succinylation of protein surface lysine residues. Cation exchange chromatography was then carried out using a succinylated protein mixture containing primarily single lysine modifications and the collected fractions were evaluated using direct infusion and tryptic digest–mass spectrometry to determine the degree of succinylation and the sites of modification on the protein surface. Electrostatic potential (EP) maps of the native protein and the variants were generated to provide insight into the elution order of the variants and the results indicated that there were two major binding regions on the protein surface. Variants showing the largest change in retention time as compared to the native protein had modified residues within the binding regions. On the other hand, variants which showed a smaller change in protein retention time had succinylated residues at locations which were not part of the two distinct binding regions. This study demonstrates that the use of controlled protein surface modification offers a convenient means of studying the relationship between protein surface properties and chromatographic binding affinity.
Modulating pulmonary inflammation (2016)

Neuroepithelial cells suppress pulmonary inflammation and alveolar remodeling [Also see Report by Branchfield et al. ]
Characterizing the sublethal effects of SmartStax PRO dietary exposure on life history traits of the western corn rootworm, Diabrotica virgifera virgifera LeConte (2022)

The western corn rootworm (WCR), Diabrotica virgifera virgifera LeConte, is an economically important pest of field corn (Zea mays L.) across the United States (U.S.) Corn Belt. Repeated use of transgenic hybrids expressing Bacillus thuringiensis (Bt) proteins has selected for field-evolved resistance to all current rootworm-active Bt proteins. The newest product available for WCR management is SmartStax® PRO, a rootworm-active pyramid containing Cry3Bb1, Cry34/35Ab1 [now reclassified as Gpp34Ab1/Tpp35Ab1] and a new mode of action, DvSnf7 dsRNA. Understanding the fitness of adult WCR after dietary exposure to SmartStax® PRO will identify potential impacts on WCR population dynamics and inform efforts to optimize resistance management strategies. Therefore, the objective of the present study was to characterize the effect of SmartStax® PRO dietary exposure on WCR life history traits. Adult WCR were collected during 2018 and 2019 from emergence tents placed over replicated field plots of SmartStax® PRO or non-rootworm Bt corn at a site with a history of rootworm-Bt trait use and suspected resistance to Cry3Bb1 and Cry34/35Ab1. Adult survival was reduced by 97.1-99.7% in SmartStax® PRO plots relative to the non-rootworm Bt corn plots during the study. Individual male/female pairs were fed different diets of ear tissue to simulate lifetime or adult exposure. Life history parameters measured included adult longevity, adult head capsule width, lifetime female egg production, and egg viability. Results indicate that lifetime or adult exposure to SmartStax® PRO significantly reduced adult longevity and lifetime egg production. Larval exposure to SmartStax® PRO significantly reduced WCR adult size. Results from this study collectively suggest that SmartStax® PRO may negatively impact WCR life history traits, which may lead to reduced population growth when deployed in an area with WCR resistance to Bt traits.
Tratamiento de lesiones cervicales no cariadas: cuándo, porqué y cómo (2020)

Las lesiones cervicales no cariadas (LCNC) implican la perdida de tejido duro de las zonas cervicales dentales a traves de procesos no relacionados con la caries. En la actualidad, las LCNC constituyen una patologia comun causada por cambios en el estilo de vida y la dieta. La 
prevalencia y la gravedad del desgaste cervical aumentan con la edad. En general, se acepta que no hay un unico factor que genera las lesiones, sino que estas se deben a una combinacion de factores. Entre los factores considerados como relacionados con la formacion y 
progresion de las LCNC se encuentran la biocorrosion (erosion), la friccion (abrasion) y posiblemente el estres oclusal (abfraccion). El aspecto clinico de las LCNC puede variar en funcion del tipo y la gravedad de los factores etiologicos implicados. Los clinicos deben seguir una lista 
de control para llegar a un diagnostico preciso de la etiologia de las LCNC multifactoria!es. 
La prevencion y el manejo satisfactorios de las LCNC exigen un conocimiento de la etiologia y los factores de riesgo, incluyendo el saber como cambian con el tiempo en pacientes individuales. La decision de monitorizar las LCNC en lugar de intervenir debe basarse en la progresion de las lesiones y la manera en que comprometen la vitalidad, la funcion y la estetica de los dientes. Las opciones terapeuticas incluyen tecnicas para aliviar la hipersensibilidad dentinaria y la colocacion de una restauracion adhesiva, eventualmente en combinacion con un procedimiento quirurgico de recubrimiento radicular. La restauracion adhesiva se considera como la ultima opcion terapeutica en las LCNC. 
La indicacion general para colocar restauraciones de composite en casos de LCNC se basa en las excelentes propiedades esteticas y el buen rendimiento clinico de las mismas. El rendimiento clinico de estas restauraciones depende altamente del producto, en particular, en lo que se refiere al sistema adhesivo utilizado. En ensayos clinicos, se ha visto que el tipo de material de composite no parece tener una influencia 
significativa en el rendimiento clinico de las restauraciones en casos de LCNC. Un aspecto mucho mas importante es que el profesional realice 
correctamente el procedimiento clinico. 
Con frecuencia, se observa una degradacion marginal conforme avanza el envejecimiento. Las medidas de mantenimiento anual con un posible nuevo pulido de los margenes de la restauracion prolongaran su vida util.
Biochemical Assay-Based Selectivity Profiling of Clinically Relevant Kinase Inhibitors on Mutant Forms of EGF Receptor (2008)

Gefitinib and erlotinib are potent EGFR tyrosine kinase inhibitors (potentially) useful for the treatment of non-small-cell lung cancer (NSCLC). Clinical responses, however, in NSCLC patients have been linked to the presence of certain activating mutations of EGFR. We used an ELISA-based biochemical assay to confirm the selective inhibitory efficacy of gefitinib and erlotinib on the activated mutant receptor. Our results are in line with the clinical observations providing evidence for the predictive power of the kinase assay. Four additional compounds were also investigated: CI-1033 and EKB-569 had dramatic inhibitory effects on all EGFR forms, whereas PD153035 and AG1478 were active on wild-type and activating mutant protein. In docking simulations with wild-type EGFR, our inhibitory data are in good agreement with the binding scores. These data confirm that anilinoquinazolines are good starting structures for the next generation of selective drugs against mutant EGFR, whereas CI-1033 and EKB-569 may represent advances for patients with both wild-type and anilinoquinazoline-resistant mutant tumors.
Application of TSDC technique in study of relaxation during curing process of RTV silicone rubbers (2002)

Two types of room-temperature-vulcanized silicone rubber high-voltage outdoor insulator coatings were cured for different periods up to 600 hours at 25/spl deg/C and 80% relative humidity. The thermally stimulated discharging current (TSDC) of samples with different curing degrees, ie., being cured for different periods, was measured at a heating rate of 7/spl deg/C/min over the temperature range of 25 to 180/spl deg/C. It was found that the TSD current peak temperature, T/sub m/, increased with increase of curing period, and saturated finally at a stabilized value when the curing process was completed. The net increases of T/sub m/S, from the beginning to the completion of the curing, were 25 and 35/spl deg/C, respectively, for the two types of samples. A logarithmic relationship between the T/sub m/ and the curing time, t/sub c/, was established on the basis of experimental data. An expression for the relaxation time in the terms of t/sub c/ was derived based on the TSDC theory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection (2022)

The unprecedented magnitude of the 2013-2016 Ebola virus (EBOV) epidemic in West Africa resulted in over 11 000 deaths and spurred an international public health emergency. A second outbreak in 2018-2020 in DRC resulted in an additional >3400 cases and nearly 2300 deaths (WHO, 2020). These large outbreaks across geographically diverse regions highlight the need for the development of effective oral therapeutic agents that can be easily distributed for self-administration to populations with active disease or at risk of infection. Herein, we report the in vivo efficacy of N<sup>4</sup>-hydroxycytidine (EIDD-1931), a broadly active ribonucleoside analog and the active metabolite of the prodrug EIDD-2801 (molnupiravir), in murine models of lethal EBOV infection. Twice daily oral dosing with EIDD-1931 at 200 mg/kg for 7 days, initiated either with a prophylactic dose 2 h before infection, or as therapeutic treatment starting 6 h post-infection, resulted in 92-100% survival of mice challenged with lethal doses of EBOV, reduced clinical signs of Ebola virus disease (EVD), reduced serum virus titers, and facilitated weight loss recovery. These results support further investigation of molnupiravir as a potential therapeutic or prophylactic treatment for EVD.
Advanced Ground Systems Maintenance Physics Models For Diagnostics Project (2015)

The project will use high-fidelity physics models and simulations to simulate real-time operations of cryogenic and systems and calculate the status/health of the systems. The project enables the delivery of system health advisories to ground system operators. The capability will also be used to conduct planning and analysis of cryogenic system operations. This project will develop and implement high-fidelity physics-based modeling techniques tosimulate the real-time operation of cryogenics and other fluids systems and, when compared to thereal-time operation of the actual systems, provide assessment of their state. Physics-modelcalculated measurements (called pseudo-sensors) will be compared to the system real-timedata. Comparison results will be utilized to provide systems operators with enhanced monitoring ofsystems' health and status, identify off-nominal trends and diagnose system/component failures.This capability can also be used to conduct planning and analysis of cryogenics and other fluidsystems designs. This capability will be interfaced with the ground operations command andcontrol system as a part of the Advanced Ground Systems Maintenance (AGSM) project to helpassure system availability and mission success. The initial capability will be developed for theLiquid Oxygen (LO2) ground loading systems.