gebhart/patrepeval huggingface dataset:
Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy (2014)

Energy depletion has been highlighted as an important contributor to the pathology of hypertrophic cardiomyopathy (HCM), a common inherited cardiac disease. Pharmacological reversal of energy depletion appears an attractive approach and the use of perhexiline has been proposed as it is thought to shift myocardial metabolism from fatty acid to glucose utilisation, increasing ATP production and myocardial efficiency. We used the Mybpc3-targeted knock-in mouse model of HCM to investigate changes in the cardiac metabolome following perhexiline treatment. Echocardiography indicated that perhexiline induced partial improvement of some, but not all hypertrophic parameters after six weeks. Non-targeted metabolomics, applying ultra-high performance liquid chromatography-mass spectrometry, described a phenotypic modification of the cardiac metabolome with 272 unique metabolites showing a statistically significant change (p < 0.05). Changes in fatty acids and acyl carnitines indicate altered fatty acid transport into mitochondria, implying reduction in fatty acid beta-oxidation. Increased glucose utilisation is indirectly implied through changes in the glycolytic, glycerol, pentose phosphate, tricarboxylic acid and pantothenate pathways. Depleted reduced glutathione and increased production of NADPH suggest reduction in oxidative stress. These data delineate the metabolic changes occurring during improvement of the HCM phenotype and indicate the requirements for further targeted interventions.
Changes in Doppler‐Derived Kidney Venous Flow and Adverse Cardiorenal Outcomes in Patients With Heart Failure (2023)

Background The impact of changes in Doppler-derived kidney venous flow in heart failure (HF) is not well studied. We aimed to investigate the association of Doppler-derived kidney venous stasis index (KVSI) and intrakidney venous-flow (IKVF) patterns with adverse cardiorenal outcomes in patients with HF. Methods and Results In this observational cohort study, consecutive inpatients with HF referred to a nephrologist because of a history of diuretic resistance and abnormal kidney function (n=216) underwent spectral kidney assessments after admission (Doppler 1) and 25 to 35 days later (Doppler 2) to identify IKVF patterns (continuous/pulsatile/biphasic/monophasic) and KVSI levels. Cox proportional hazard regression models were used to evaluate the associations between KVSI/IKVF patterns at Doppler 1 as well as changes from Doppler 1 to Doppler 2 and risk of cardiorenal events up to 18 months after admission. Worsening HF or death occurred in 126 patients. Both baseline KVSI (hazard ratio [HR], 1.49 [95% CI, 1.37-1.61] per 0.1-unit increase) and baseline IKVF pattern (HR, 2.47 [95% CI, 2.01-3.04] per 1 pattern severity increase) were significantly associated with worsening HF/death. Increases in both KVSI and IKVF pattern severity from Doppler 1 to 2 were also associated with an increased risk of worsening HF/death (HR, 3.00 [95% CI, 2.08-4.32] per 0.1-unit increase change; and HR, 6.73 [95% CI, 3.27-13.86] per 1 pattern increase in severity change, respectively). Similar results were observed for kidney outcomes. Conclusions Baseline kidney venous flow predicted adverse cardiorenal events, and inclusion of serial kidney venous flow in cardiorenal risk stratification could facilitate clinical decision-making for patients with HF. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT03039959.
A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast (2004)

The mammalian tumor suppressor, phosphatase and tensin homologue deleted on chromosome 10 (PTEN), inhibits cell growth and survival by dephosphorylating phosphatidylinositol-(3,4,5)-trisphosphate (PI[3,4,5]P3). We have found a homologue of PTEN in the fission yeast, Schizosaccharomyces pombe (ptn1). This was an unexpected finding because yeast (S. pombe and Saccharomyces cerevisiae) lack the class I phosphoinositide 3-kinases that generate PI(3,4,5)P3 in higher eukaryotes. Indeed, PI(3,4,5)P3 has not been detected in yeast. Surprisingly, upon deletion of ptn1 in S. pombe, PI(3,4,5)P3 became detectable at levels comparable to those in mammalian cells, indicating that a pathway exists for synthesis of this lipid and that the S. pombe ptn1, like mammalian PTEN, suppresses PI(3,4,5)P3 levels. By examining various mutants, we show that synthesis of PI(3,4,5)P3 in S. pombe requires the class III phosphoinositide 3-kinase, vps34p, and the phosphatidylinositol-4-phosphate 5-kinase, its3p, but does not require the phosphatidylinositol-3-phosphate 5-kinase, fab1p. These studies suggest that a pathway for PI(3,4,5)P3 synthesis downstream of a class III phosphoinositide 3-kinase evolved before the appearance of class I phosphoinositide 3-kinases.
Titelbild: Synthese, motorische Verbrennung, Emissionen: Chemische Aspekte des Kraftstoffdesigns (Angew. Chem. 20/2017) (2017)

Auf dem Weg zum “Kraftstoff-Design-Prozess” Um bei vielversprechenden Molekülstrukturen für maßgeschneiderte Kraftstoffe der Zukunft zu landen, müssen nachhaltige Produktionswege nicht nur Rohstoffeigenschaften und möglichst einfache Umwandlungsschritte berücksichtigen, sondern sich auch auf fundiertes Wissen über motorische Verbrennung und Schadstoffausstoß stützen. Wie man dieses Ziel im “Rückwärtsgang” von molekularen Leitstrukturen zu erfolgreichen Produktionsprozessen erreichen kann, verdeutlicht der Aufsatz auf S. 5500 ff. von W. Leitner, J. Klankermayer, K. Kohse-Höinghaus et al. Auf dem Weg zum “Kraftstoff-Design-Prozess” Um bei vielversprechenden Molekülstrukturen für maßgeschneiderte Kraftstoffe der Zukunft zu landen, müssen nachhaltige Produktionswege nicht nur Rohstoffeigenschaften und möglichst einfache Umwandlungsschritte berücksichtigen, sondern sich auch auf fundiertes Wissen über motorische Verbrennung und Schadstoffausstoß stützen. Wie man dieses Ziel im “Rückwärtsgang” von molekularen Leitstrukturen zu erfolgreichen Produktionsprozessen erreichen kann, verdeutlicht der Aufsatz auf S. 5500 ff. von W. Leitner, J. Klankermayer, K. Kohse-Höinghaus et al. Wässrige Superkondensatoren Metall-organische Gerüste Heterogene Katalyse
Wide Area Intruder Detection System with a Pair of Transceiver Cables (2007)

We have developed a wide area intruder detection surveillance system which was delivered to the Japanese market last summer. This technology is known as MELWATCH which stands for MELco WATCH(to keep lookout). It has been installed at several sites in Japan. MELWATCH is composed of a pair of sensor cables, a sensor unit and an intrusion detection terminal. The sensor cables are composed of a transmission and a receiving cable (transceiver cables), both of which are off-the-shelf leaky coaxial cables. The sensor cables are deployed in parallel along the boundary to be monitored. Upon activation, the sensor unit sends an electric wave into the transmission cable which results in the electric wave leaks from the cable. The receiving cable receives the leaked electric wave and an electric field is formed between the cables. When an intruder enters the electric field, the sensor unit detects this activity and the precise location of the intrusion. Moreover, this sensor is less affected by the environmental noise, such as trees or small animals, nor weather conditions. In addition, the ability to specify the intrusion point makes it possible to configure the more sophisticated system with pan-tilt-zoom cameras. In this paper, we show the effectiveness of MELWATCH through the field data of the several installed sites.
Demonstration of OAM-based MIMO FSO link using spatial diversity and MIMO equalization for turbulence mitigation (2016)

We experimentally demonstrate and investigate the performance of a multi-input-multiple-output (MIMO) free-space optical link employing orbital-angular-momentum multiplexing through turbulent channel. We show that turbulence effects can be mitigated by exploiting spatial diversity and MIMO equalization.
Constructive Interference through Symbol Level Precoding for Multi-Level Modulation (2015)

The constructive interference concept in the downlink of multiple-antenna systems is addressed in this paper. The concept of the joint exploitation of the channel state information (CSI) and data information (DI) is discussed. Using symbol-level precoding, the interference between data streams is transformed Under certain conditions into useful signal that can improve the signal to interference noise ratio (SINR) of the downlink transmissions. In the previous work, different constructive interference precoding techniques have been proposed for the MPSK scenario. In this context, a novel constructive interference precoding technique that tackles the transmit power minimization (min-power) with individual SINR constraints at each user's receivers is proposed assuming MQAM modulation. Extensive simulations are performed to validate the proposed technique.
Tomography of ultrarelativistic nuclei with polarized photon-gluon collisions (2023)

A linearly polarized photon can be quantized from the Lorentz-boosted electromagnetic field of a nucleus traveling at ultrarelativistic speed. When two relativistic heavy nuclei pass one another at a distance of a few nuclear radii, the photon from one nucleus may interact through a virtual quark-antiquark pair with gluons from the other nucleus, forming a short-lived vector meson (e.g., ρ<sup>0</sup>). In this experiment, the polarization was used in diffractive photoproduction to observe a unique spin interference pattern in the angular distribution of ρ<sup>0</sup> → π<sup>+</sup>π<sup>-</sup> decays. The observed interference is a result of an overlap of two wave functions at a distance an order of magnitude larger than the ρ<sup>0</sup> travel distance within its lifetime. The strong-interaction nuclear radii were extracted from these diffractive interactions and found to be 6.53 ± 0.06 fm (<sup>197</sup>Au) and 7.29 ± 0.08 fm (<sup>238</sup>U), larger than the nuclear charge radii. The observable is demonstrated to be sensitive to the nuclear geometry and quantum interference of nonidentical particles.
Brigadier General Herbert W. Love, 1913-1988 (1988)

Herbert W. Love, a former executive director of the Arctic Institute of North America, died in Green Valley, Arizona, on 14 March 1988. ... As its executive director, General Love served the Institute, and served it well, from the time he took over in January 1968 until he left it under somewhat turbulent circumstances in May 1975. His major regret in the change of direction of the Institute was that an independent and joint Canadian-United States organization was no longer possible. General Love had a long and distinguished military career both overseas and in Canada.
Accommodation at the interface of highly dissimilar semiconductor/oxide epitaxial systems (2009)

An equilibrium model describing accommodation at epitaxial interfaces of highly dissimilar material systems is presented. For large lattice mismatches and large interface energies, the material nucleates with its bulk lattice parameter, mismatch being accommodated by interface dislocations. No threading defects are formed, contrasting with standard plastic relaxation mechanisms. It is shown that good quality InP can be grown on ${\text{SrTiO}}_{3}$ (STO) despite the large mismatch. This opens perspectives for the monolithic integration of InP on STO/Si templates and for the widening of the application spectrum of heteroepitaxy.
A novel bioabsorbable drug‐eluting tracheal stent (2011)

This study reports on the development of a novel bioabsorbable tracheal stent with sustained MMC drug elution for preventing tracheal stenosis. Further studies are warranted to optimize stent design and drug dosage.
Frequency-narrowed tunable external-cavity 2.5-W diode laser for spin-exchange optical pumping (2000)

Summary form only given. Liter quantities of spin-polarized /sup 129/Xe are of utility for a number of applications, including MRI. The hyperpolarized /sup 129/Xe is produced via spin-exchange collisions with laser-polarized Rb atoms. Commercially available diode arrays, while compact and inexpensive, have bandwidths of typically 2-3 nm, far in excess of the 0.1-0.3 nm pressure-broadened Rb absorption linewidth. Recently, Levron et al. (see Appl. Phys. Lett. vol. 73, p. 2666, 1998), frequency narrowed a custom 1-W diode to use for spin-exchange optical pumping of Xe using Cs instead of Rb. The resulting 0.3-W output with 0.12-nm bandwidth gave Xe polarizations of 2.5%. Here we achieve nearly a factor of 10 increase in power at the same linewidth using commercial broad area diode lasers (BALs) with external-cavity feedback.
Myopia—The Silent Epidemic That Should Not Be Ignored (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
Design and Full-Scale Testing of Low-Cost Texas Department of Transportation Type T631 Bridge Rail for MASH Test Level 2 and 3 Applications (2015)

The purpose of this project was to design and test a low-cost bridge rail system that would be compatible with the Midwest Guardrail System (31 in. height) and minimized or eliminated deck damage when impacted by errant vehicles. The Texas Type T631 bridge rail developed for this project is a flexible, low-cost bridge rail system for Test Level 2 (TL-2) applications. The Texas Department of Transportation Type T631 bridge rail designed and developed for this project was evaluated under Manual for Assessing Safety Hardware (MASH) TL-2 in 2013. The bridge rail incorporated S3X5.7 steel sections designed to yield at the post baseplate. The post baseplate was designed to distribute the baseplate bearing and shear forces without causing damage to the 8-in.-thick reinforced concrete deck. The welds on the posts were designed such that the post yielded without tearing away from the top of the baseplate. The rail element consisted of a 12-gauge W-beam rail element. The rail element was attached to the post with a bolt of diameter 5/16 in. This bolt was designed to break away without adversely affecting vehicle performance. The posts were spaced 6 ft 3 in. on centers for TL-2. The post spacing was reduced to 3 ft 1½ in. on centers and evaluated for MASH Test Level 3 (TL-3) specifications in 2014. At the smaller post spacing, the T631 met all the performance requirements of MASH TL-3. Details of the design and testing of the T631 for MASH TL-2 and MASH TL-3 specifications are provided in this paper.
Activation of mitochondrial TUFM ameliorates metabolic dysregulation through coordinating autophagy induction (2021)

Disorders of autophagy, a key regulator of cellular homeostasis, cause a number of human diseases. Due to the role of autophagy in metabolic dysregulation, there is a need to identify autophagy regulators as therapeutic targets. To address this need, we conducted an autophagy phenotype-based screen and identified the natural compound kaempferide (Kaem) as an autophagy enhancer. Kaem promoted autophagy through translocation of transcription factor EB (TFEB) without MTOR perturbation, suggesting it is safe for administration. Moreover, Kaem accelerated lipid droplet degradation in a lysosomal activity-dependent manner in vitro and ameliorated metabolic dysregulation in a diet-induced obesity mouse model. To elucidate the mechanism underlying Kaem's biological activity, the target protein was identified via combined drug affinity responsive target stability and LC-MS/MS analyses. Kaem directly interacted with the mitochondrial elongation factor TUFM, and TUFM absence reversed Kaem-induced autophagy and lipid degradation. Kaem also induced mitochondrial reactive oxygen species (mtROS) to sequentially promote lysosomal Ca<sup>2+</sup> efflux, TFEB translocation and autophagy induction, suggesting a role of TUFM in mtROS regulation. Collectively, these results demonstrate that Kaem is a potential therapeutic candidate/chemical tool for treating metabolic dysregulation and reveal a role for TUFM in autophagy for metabolic regulation with lipid overload.
Mikrostrukturierung von Oberflächen durch reaktive Polymerbeschichtungen (2001)

Durch chemische Dampfabscheidung (CVD) wurden verschiedenartige Substrate mit einem hochreaktiven Polymer beschichtet, das aktive Pentafluorphenylestergruppen enthält (siehe Schema). Durch Mikrokontaktdrucken wurden dann Biotin-modifizierte Mikrostrukturen auf der Substratoberfläche hergestellt, die spezifisch mit Fluorescein-markiertem Streptavidin wechselwirken und somit auch fluoreszenzmikroskopisch sichtbar gemacht werden können.
An Expressive (Zero-Knowledge) Set Accumulator (2017)

We present a new construction of an expressive set accumulator. Unlike existing cryptographic accumulators, ours provides succinct proofs for a large collection of operations over accumulated sets, including intersection, union, set difference, SUM, COUNT, MIN, MAX, and RANGE, as well as arbitrary nestings of the above. We also show how to extend our accumulator to be zero-knowledge. The security of our accumulator is based on extractability assumptions and other assumptions that hold in the generic group model. Our construction has asymptotically optimal verification complexity and proof size, constant update complexity, and public verifiability/updatability-namely, any client who knows the public key and the last accumulator value can verify the supported operations and update the accumulator. The expressiveness of our accumulator comes at the cost of quadratic prover time. However, we show that the cryptographic operations involved are cheap compared to those incurred by generic approaches (e.g., SNARKs) that are equally expressive: our prover runs faster for sets of up to 5 million items. Our accumulator serves as a powerful cryptographic tool with many applications. For example, it can be applied to efficiently support verification of a rich collection of SQL queries when used as a drop-in replacement in existing verifiable database systems (e.g., IntegriDB, CCS 2015).
Wireless Information and Power Transfer in Multiway Massive MIMO Relay Networks (2016)

Simultaneous wireless information and power transfer techniques for multiway massive multiple-input multiple-output (MIMO) relay networks are investigated. By using two practically viable relay receiver designs, namely 1) the power splitting receiver and 2) the time switching receiver, asymptotic signal-to-interference-plus-noise ratio (SINR) expressions are derived for an unlimited number of antennas at the relay. These asymptotic SINRs are then used to derive asymptotic symmetric sum rate expressions in closed form. Notably, these asymptotic SINRs and sum rates become independent of radio frequency-to-direct current (RF-to-DC) conversion efficiency in the limit of infinitely many relay antennas. Moreover, tight average sum rate approximations are derived in closed form for finitely many relay antennas. The fundamental tradeoff between the harvested energy and the sum rate is quantified for both relay receiver structures. Notably, the detrimental impact of imperfect channel state information (CSI) on the MIMO detector/precoder is investigated, and thereby, the performance degradation caused by pilot contamination, which is the residual interference due to nonorthogonal pilot sequence usage in adjacent/cochannel systems, is quantified. The presence of cochannel interference (CCI) can be exploited to be beneficial for energy harvesting at the relay, and consequently, the asymptotic harvested energy is an increasing function of the number of cochannel interferers. Notably, in the genie-aided perfect CSI case, the detrimental impact of CCI for signal decoding can be cancelled completely whenever the number of relay antennas grows without bound. Nevertheless, the pilot contamination severely degrades the sum rate performance even for infinitely many relay antennas.
Accuracy Evaluation of an Equivalent Synchronization Method for Assessing the Time Reference in Power Networks (2017)

This paper deals with the evaluation of the accuracy performance of an approach for assessing the phase displacement between voltages at power network nodes. This task is accomplished by processing asynchronous measurements taken at each node. This turns into an equivalent synchronization, which is, therefore, obtained without exploiting any synchronization signals, such as the ones provided by means of wireless (i.e., global positioning system) or wired technologies. As a matter of fact, distribution system operators will gain the possibility of deploying, at more affordable costs, wide area measurement system (WAMS) over their power networks for enhancing their stability and reliability. Phasor measurement units (PMUs) are the most common examples of such WAMS, but, besides their high cost, there are circumstances where providing a time reference signal to remote PMUs often becomes a difficult task. This paper aims at recalling the basic theoretical principles of the method and at proving its applicability in power network through a deep analysis of its metrological performance.
Intraspecific diversity of Edwardsiella ictaluri isolates from diseased freshwater catfish, Pangasianodon hypophthalmus (Sauvage), cultured in the Mekong Delta, Vietnam (2012)

A molecular epidemiology study was conducted on 90 Edwardsiella ictaluri isolates recovered from diseased farmed freshwater catfish, Pangasianodon hypophthalmus, cultured in the Mekong Delta, Vietnam. Thirteen isolates of E. ictaluri derived from diseased channel catfish, Ictalurus punctatus, cultured in the USA were included for comparison. All the E.ictaluri isolates tested were found to be biochemically indistinguishable. A repetitive (rep)-PCR using the single (GTG)(5) primer was shown to possess limited discriminatory power, yielding two similar DNA profiles categorized as (GTG)(5) -PCR group 1 or 2 among the Vietnam isolates and (GTG)(5) -PCR group 1 within the USA isolates. Macrorestriction analysis identified 14 and 22 unique pulsotypes by XbaI and SpeI, respectively, among a subset of 59 E. ictaluri isolates. Numerical analysis of the combined macrorestriction profiles revealed three main groups: a distinct cluster formed exclusively of the USA isolates, and a major and minor cluster with outliers contained the Vietnam isolates. Antibiotic susceptibility and plasmid profiling supported the existence of the three groups. The results indicate that macrorestriction analysis may be regarded as a suitable typing method among the E. ictaluri species of limited intraspecific diversity. Furthermore, the findings suggest that E. ictaluri originating from Vietnam may constitute a distinct genetic group.