gebhart/patrepeval huggingface dataset:
Preface to the International Workshop on Spatial and Spatio-Temporal Data Mining (2011)

With advances in remote sensors, sensor networks, and proliferation of location sensing devices into common walks of lives and businesses, the generation of disparate, dynamic, and geographically distributed spatiotemporal data has exploded in recent years.Knowledge extracted from spatial and spatiotemporal data plays a critical role in our daily lives, whether it is to understand the human implications of global environmental changes, responding to natural disasters, or simply finding alternate routes in case of an emergency.However, unprecedented data growth is leading into a data-rich but information-poor environment as the rate at which the geospatial data being generated clearly exceeds our ability to organize and analyze it to extract useful patterns that are critical to the understanding of dynamically changing world in a timely manner.It is therefore, imperative that efficient and effective data mining techniques are needed for extracting useful information from these large heterogeneous and multi-modal datasets.However, traditional data mining techniques are ineffective, as they donÕt incorporate idiosyncrasies of spatial domain, such as, spatial autocorrelation, spatial context, and spatial constraints.Recognizing the need for an international forum to disseminate research results and discuss the needs of the spatial and spatiotemporal data mining community, the SSTDM series of workshops were started in 2006 as satellite event with IEEE ICDM.Initial workshops (SSTDM/ICDM-06, SSTDM/ICDM-07, STDM/ICDE-07) have mostly focused on algorithmic aspects of SSTDM on vector data types.Starting with ICDM-08, SSTDM workshop was combined with GeoInformatics (DM4GeoInformatics) workshop, which brought together vector and raster datasets, and theory and applications under a single platform.Popularity of SSTDM workshop has steadily increased over the years owing to several factors: recognition and broadening of the field, increasing applications, especially in geo-intelligence, climate, and earth sciences, and finally increasing quality and quantity of submissions and participants.Moreover, SSTDM remained highly appealing to the ICDM authors, as more and more authors are selecting SSTDM as their preferred workshop.The workshop is also found to be highly useful to participants due to the quality and relevance of invited speakers.This year we had received 21 submissions of which 7 full papers and 4 short were selected based on minimum of three PC reviews.In addition to the presentation of these technical papers, workshop will also feature a keynote talk.SSTDM workshop will continue to provide a leading international forum for researchers, developers, and practitioners in the field of geoinformatics to identify current research foci, vital areas of need, and critical points of synergy.
Characterization of a mitomycin-binding drug resistance mechanism from the producing organism, Streptomyces lavendulae (1997)

In an effort to characterize the diversity of mechanisms involved in cellular self-protection against the antitumor antibiotic mitomycin C (MC), DNA fragments from the producing organism (Streptomyces lavendulae) were introduced into Streptomyces lividans and transformants were selected for resistance to the drug. Subcloning of a 4.0-kb BclI fragment revealed the presence of an MC resistance determinant, mrd. Nucleotide sequence analysis identified an open reading frame consisting of 130 amino acids with a predicted molecular weight of 14,364. Transcriptional analysis revealed that mrd is expressed constitutively, with increased transcription in the presence of MC. Expression of mrd in Escherichia coli resulted in the synthesis of a soluble protein with an Mr of 14,400 that conferred high-level cellular resistance to MC and a series of structurally related natural products. Purified MRD was shown to function as a drug-binding protein that provides protection against cross-linking of DNA by preventing reductive activation of MC.
Block Error Rate Performance of OFDM with Faster-than-Nyquist Signaling Using TDM Based Reference Signal Multiplexing (2019)

This paper presents the average block error rate (BLER) performance using time division multiplexing (TDM) based reference signal (RS) multiplexing for faster-than-Nyquist (FTN) signaling in orthogonal frequency division multiplexing (OFDM). We propose a subframe structure in which a cyclic prefix (CP) is appended to only the TDM based RS block and the first FTN symbol to achieve accurate estimation of the channel response in a multipath fading channel with a low CP overhead. We apply a minimum mean square error based turbo soft interference canceller to suppress high-level inter-symbol-interference (ISI) and inter-subcarrier-interference (ICI) caused by FTN signaling. Computer simulation results show that the loss in the required average received signal-to-noise power ratio satisfying the average BLER of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> of FTN signaling using the TDM RS based channel estimation with the proposed subframe structure is decreased by approximately 1.2 and 1.8 dB. This is compared to that assuming ideal channel estimation for QPSK and 16QAM, respectively, when the improvement ratio of the spectral efficient from CP-OFDM is 1.31 with the rate-1/2 turbo code.
Therapy-related myelodysplastic syndromes deserve specific diagnostic sub-classification and risk-stratification—an approach to classification of patients with t-MDS (2020)

In the current World Health Organization (WHO)-classification, therapy-related myelodysplastic syndromes (t-MDS) are categorized together with therapy-related acute myeloid leukemia (AML) and t-myelodysplastic/myeloproliferative neoplasms into one subgroup independent of morphologic or prognostic features. Analyzing data of 2087 t-MDS patients from different international MDS groups to evaluate classification and prognostication tools we found that applying the WHO classification for p-MDS successfully predicts time to transformation and survival (both p < 0.001). The results regarding carefully reviewed cytogenetic data, classifications, and prognostic scores confirmed that t-MDS are similarly heterogeneous as p-MDS and therefore deserve the same careful differentiation regarding risk. As reference, these results were compared with 4593 primary MDS (p-MDS) patients represented in the International Working Group for Prognosis in MDS database (IWG-PM). Although a less favorable clinical outcome occurred in each t-MDS subset compared with p-MDS subgroups, FAB and WHO-classification, IPSS-R, and WPSS-R separated t-MDS patients into differing risk groups effectively, indicating that all established risk factors for p-MDS maintained relevance in t-MDS, with cytogenetic features having enhanced predictive power. These data strongly argue to classify t-MDS as a separate entity distinct from other WHO-classified t-myeloid neoplasms, which would enhance treatment decisions and facilitate the inclusion of t-MDS patients into clinical studies.
ChemInform Abstract: Elimination versus Ring Opening: A Convergent Route to Alkylidene‐Cyclobutanes. (2012)

Abstract Functionalized alkylidene‐cyclobutanes (VI), (VIII), and (XI) are prepared from 2‐fluoropyridinyl‐6‐oxy precursors (IV) derived from vinyl cyclobutanols by a radical addition—elimination process.
Hollow Fiber Sorbents for Desulfurization of Natural Gas (2010)

Pipeline natural gas is the primary fuel of choice for distributed fuel cell-based applications due to its well-developed infrastructure. The concentration of sulfur in odorized pipeline natural gas is about 30 ppm, with the acceptable level being <1 ppm for catalyst stability in such applications. Packed bed technology for desulfurization suffers from several disadvantages including high pressure drop and slow regeneration rates that require large unit sizes. This paper describes a new sorption platform utilizing hollow fibers with polymer “binder”, impregnated with high loadings of sulfur selective zeolite sorbent “fillers”. Temperature Swing Adsorption (TSA) can be utilized to thermally cycle the sorbents between sorption and regeneration cycles. A simplified flow pattern minimizes pressure drop, while a porous core morphology maximizes sorption efficiencies and high surface area to volume ratio structures can enable smaller bed sizes. This new technology represents a fusion of membrane science and adsorption technology.
Computed Tomography Evaluation of Superior-Segment Facet-Joint Violation After Pedicle Instrumentation of the Lumbar Spine With a Midline Surgical Approach (2006)

The left side, single-level fusion, and most cephalad pedicle screws at L5 are targets for interventions to reduce pedicle violations in this procedure.
Photoinduced Electron Transfer in 2-tert-Butyl-3-(Anthracen-9-yl)-2,3-Diazabicyclo[2.2.2]octane (2006)

Intramolecular photoinduced electron transfer from a hydrazine unit to an aromatic group is studied by resonance Raman spectroscopy and electronic absorption spectroscopy. Substituted hydrazine functional groups have played an important role in studies of electron-transfer reactions, photoinduced intramolecular electron transfer, and of mixed valence. A prototypical compound, 2-tert-butyl-3-(anthracen-9-yl)-2,3-diazabicyclo[2.2.2]octane, that has the hydrazine-to-anthracene charge-transfer band in a region of the visible spectrum suitable for detailed resonance Raman spectroscopy is studied in detail. Excitation profiles are obtained, calculated quantitatively by using time-dependent theoretical methods, and interpreted with the assistance of molecular orbital calculations. Excited-state distortions are calculated. The largest distortions occur on the hydrazine unit; the normal mode showing the largest distortion (659 cm(-1), calculated at 665 cm(-1)) involves an out-of-plane C-N-N-C bend consistent with removing an electron from the N-N pi antibonding orbital. Anthracene ring-centered C-C stretches also are enhanced, consistent with populating an antibonding pi orbital centered on the ring. Excellent fits to all of the excitation profiles and to the absorption band are obtained using one set of excited-state potential surfaces.
Reflection Photoelastic Tomography for the Detection of Axial Stress Distribution in Planar Optical Waveguides (2007)

In this paper a novel scheme of photoelastic tomography is described, to be applied to planar waveguides. It exploits the reflection of the laser probe beam at the waveguide-substrate interface to reconstruct stress distributions in waveguide cross sections. By this technique, spurious or induced local stress variations in integrated optics components can also be brought into evidence.
ChemInform Abstract: Aldol Reactions in Multicomponent Reaction Based Domino Pathways: A Multipurpose Enabling Tool in Heterocyclic Chemistry. (2013)

Abstract Combination of the aldol reaction with the Ugi multicomponent reaction affords highly functionalized mono‐ and polycyclic ring systems.
Revision Surgery for “Real” Recurrent Lumbar Disk Herniation (2016)

The incidence of revision surgery for real-RLDH is relatively low. It is essential to pay careful attention to prevent a dural tear. Patients may expect clinical outcomes similar to those following primary discectomy.
Instruction buffering exploration for low energy VLIWs with instruction clusters (2005)

For multimedia applications, loop buffering is an efficient mechanism to reduce the power in the instruction memory of embedded processors. In particular, sofrwcre controlled clustered loop buffers are energy efficient. However current compilers for VLIW do not fully exploit the potentials offered by such a clustered organization This paper presents an algorithm to explore what is the optimal loop huffer configuration and the optimal way to use this configuration for an application or a set of applications. Results for the MediaBeneh application suite show an additional 18% reduction (on average) in energy in the instruction memory hierarchy as compared to traditional nonclustered approaches to the loop huffer without compromising performance.
P2‐124: Brain Isoprenoids and Alzheimer's Disease (2016)

The mevalonate pathway has been described to play a key role in Alzheimer's disease (AD). Farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) are non-sterol isoprenoid intermediates from mevalonate. They lead to protein prenylation which plays a crucial role in controlling cell signalling and proliferation. hFPP and hGGPP synthases lead to prenylation of small GTPase protein RhoA-cdc42, that have been shown to be associated with the accumulation of phospho-tau protein in the brain. It is hypothesise that these intermediates are implicated in tau dysregulation and the progression of AD. A better understanding of the role of hFPPs and hGGPPs in the pathophysiology of Alzheimer's disease may prove to be essential to assess the function of the isoprenoids pathway as a potential target in prevention of AD. In the first part of this work, we measured cortical mRNA levels of hFPPs and hGGPPs (RT-qPCR) and, GGPP and FPP concentrations by Liquid chromatography-tandem mass spectrometry (LC/MS/MS) in control and AD brain tissues obtained from the Douglas-Bell Brain Bank (Montréal, Canada). In the second part, hFPPs and hGGPPs inhibitors derived from the nitrogen-containing bisphosphonates (N-BP) were tested on human SH-SY5Y neurons and their effect on the accumulation of tau and Phospho-tau was measured as a function of time and concentrations. In autopsied frontal cortex, we found a significant positive correlation between mRNA levels (p<0.001, n=124), FFP and GGPP (p<0.05, n=116) and disease status. The levels of mRNA for hFFPs and hGGPPs also correlated with the amount of phospho-tau protein levels (p<0.05, n=38) and neurofibrillary tangles density (p<0.006, n=40) in frontal cortex. We also found that high levels of hFPPS and hGGPPS mRNA prevalence is significantly associated with earlier age of onset in AD (p<0.05, n=64). Finally, preliminary data indicates that our novel families of inhibitors can decrease phospho-tau levels in SH-SY5Y neurons without any detectable toxicity. Together, these results suggest that accumulation of phospho-tau in the AD brain is related to increase levels of neuronal isoprenoids; a phenomenon that could be alleviated by the administration of specific and potent bi-phosphonate derivatives. supported by the J.L. Lévesques Foundation, Canadian Institute of Health Research and FQRNT.
Flexible, Reconfigurable Capacity Output of a High-Performance 64-QAM Optical Transmitter (2012)

We experimentally demonstrate a reconfigurable optical flexible transmitter to generate arbitrary optical QAM. Optical 16-QAM and 64-QAM is generated at EVM 8.5% and 7.2% respectively. We demonstrated successful transmission through 80-km SMF-28 after compensating with 20-km DCF with negligible penalty.
Synthesis of 4,4′-Disubstituted and Spiro-tetrahydroquinolines via Photochemical Cyclization of Acrylanilides and the First Synthesis of (±)-trans-Vabicaserin (2016)

The synthesis of vabicaserin analogues bearing a quaternary center or spiro substitution at the 4-position has been studied via a [6π]-acrylanilide cyclization employing flow photochemistry in a mesoscale and microfluidic flow photoreactor. The method is also used to synthesize 4,4′-disubstituted tetrahydroquinolines and, furthermore, enables the first synthesis of (±)-<i>trans</i>-vabicaserin.
Supplementary Table S2 from High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells (2023)

&lt;p&gt;Compounds used in this study.&lt;/p&gt;
Scaleable network multicast for cooperative base stations (2008)

Cooperative joint transmission and detection algorithms have a high potential to increase the capacity of cellular radio systems. This paper investigates efficient network layer protocols to realize such cooperation over a heterogeneous, bandwidth-limited backhaul. Target systems are MIMO-OFDM cellular communication systems with flat hierarchy (no central unit), and we take 3GPP LTE as example. The proposed architecture uses IP multicast for stations receiving the same information and is scaleable by dynamically cooperating only on frequency subbands. SINR and mobility thresholds are used to first cooperate for critical cell-edge users with low mobility, where most interference reduction gain is to be expected.
Synthesis and SAR Studies of Diarylpyrrole Anticoccidial Agents. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
ChemInform Abstract: Light‐Sensitive Polypeptides (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary figures 1 through 14 from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer (2023)

&lt;p&gt;Supplementary Figure S1. Drug screening based on the measurement of GFP fluorescence by flow cytometry. Supplementary Figure S2. Dose response curves of GFP reactivation after cardiac glycosides treatment. Supplementary Figure S3. Tumor suppressor genes reactivation after treatment with validated hits. Supplementary Figure S4. Analysis DNA methylation and histone modifications following treatments with validated hits. Supplementary Figure S5. Characterization of Ca2+ fluxes in YB5 and HEK293 cells. Supplementary Figure S6: Tumor suppressor gene reactivation is dependent on CamK activity. Supplementary Figure S7. Promoter occupancy of MeCP2 is decreased after cardiac glycoside treatment. Supplementary Figure S8: Specificity of MeCP2 antibody. Supplementary Figure S9: Assessing the specificity of MeCP2 redistribution after proscillaridin treatment. Supplementary Figure S10. Percentage of YB5 cells expressing GFP after drug treatment is significantly reduced after leptomycin treatment. Supplementary Figure S11. Cell viability assays show that drug induced toxicity is dependent on CamK activity in SW48 colon cancer cell line. Supplementary Figure S12. Cell viability assays show that drug induced toxicity is dependent on CamK activity in K562 leukemia cell line. Supplementary Figure S13. Cell viability assays show that drug induced toxicity is dependent on CamK activity in HL-60 leukemia cell line. Supplementary Figure S14. Scheme describing proposed mechanism of action of newly identified candidate epigenetic drugs.&lt;/p&gt;
The Presence of a Growth Factor in Cyst Fluid from Patients with Acquired Renal Cystic Disease (ARCD) (1987)

No AccessJournal of Urology1 Jun 1987The Presence of a Growth Factor in Cyst Fluid from Patients with Acquired Renal Cystic Disease (ARCD) Ralph J. Torrence, Jeff D. Elbers, and Ralph V. Clayman Ralph J. TorrenceRalph J. Torrence More articles by this author , Jeff D. ElbersJeff D. Elbers More articles by this author , and Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)75740-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "The Presence of a Growth Factor in Cyst Fluid from Patients with Acquired Renal Cystic Disease (ARCD)." The Journal of Urology, 137(6), p. 251A © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 137Issue 6June 1987Page: 251A Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Ralph J. Torrence More articles by this author Jeff D. Elbers More articles by this author Ralph V. Clayman More articles by this author Expand All Advertisement PDF DownloadLoading ...
Simulated Entity Resolution by Diverse Means: DIMACS Work on the KDD Challenge of 2005 (2005)

on two of the groups of entity resolution problems, ER1 and ER2 for the KDD Challenge in 2005. We presume that the situation is intended to mimic, using abstracts and author information from the life sciences, some real world problem, in which it is important to recognize the identity of an individual, even though he may share that name with other individuals (ER1), or may actively seek to hide his identity by removing his own name from a work, or replacing it with an alias (ER2a, and ER2b,c). Thus specific problems investigated include author resolution, finding a missing author of a paper, and detecting a false author of a paper. The methods used to attack these problems include combinatorial cluster analysis, fusion of methods, penalized logistic regression / maximum entropy approaches, and dependency modeling. 1
Graphene Ink as a Conductive Templating Interlayer for Enhanced Charge Transport of C60-Based Devices (2016)

We demonstrate conductive templating interlayers of graphene ink, integrating the electronic and chemical properties of graphene in a solution-based process relevant for scalable manufacturing. Thin films of graphene ink are coated onto ITO, following thermal annealing, to form a percolating network used as interlayer. We employ a benchmark n-type semiconductor, C<sub>60</sub>, to study the interface of the active layer/interlayer. On bare ITO, C<sub>60</sub> molecules form films of homogeneously distributed grains; with a graphene interlayer, a preferential orientation of C<sub>60</sub> molecules is observed in the individual graphene plates. This leads to crystal growth favoring enhanced charge transport. We fabricate devices to characterize the electron injection and the effect of graphene on the device performance. We observe a significant increase in the current density with the interlayer. Current densities as high as ∼1 mA/cm<sup>2</sup> and ∼70 mA/cm<sup>2</sup> are realized for C<sub>60</sub> deposited with the substrate at 25 °C and 150 °C, respectively.
Supplementary Data S1 from Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages (2023)

&lt;p&gt;Marker genes for each cell type identified in tumor-infiltrating myeloid cells.Related to Fig.1A&lt;/p&gt;
Synthesis and absolute configuration assignments of enantiomeric forms of ifosphamide, sulfosphamide, and trofosphamide (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and absolute configuration assignments of enantiomeric forms of ifosphamide, sulfosphamide, and trofosphamideK. Pankiewicz, R. Kinas, W. J. Stec, A. B. Foster, M. Jarman, and Jan M. S. Van MaanenCite this: J. Am. Chem. Soc. 1979, 101, 26, 7712–7718Publication Date (Print):December 1, 1979Publication History Published online1 May 2002Published inissue 1 December 1979https://doi.org/10.1021/ja00520a015Request reuse permissionsArticle Views335Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (764 KB) Get e-Alertsclose Get e-Alerts