gebhart/patrepeval huggingface dataset:
Epidural Morphine Decreases Postoperative Hypertension by Attenuating Sympathetic Nervous System Hyperactivity (1989)

Twenty-four adults who were undergoing operations on the abdominal aorta were enrolled in a randomized, double-blind, placebo-controlled study in which epidural morphine sulfate (6 mg) was employed to attenuate the sympathoadrenal response to surgery to evaluate the possible contribution of sympathetic nervous system hyperactivity to postoperative hypertension. Patients who received epidural morphine required less parenteral morphine in the 24 hours following surgery, had lower analogue pain scores, and had markedly lower plasma norepinephrine levels when compared with patients in the control group who received an identical volume of saline in the epidural space. Epidural morphine had no effect on plasma epinephrine or arginine vasopressin levels. Fewer patients in the morphine group (4 of 12 vs 9 of 12 patients in the saline group) required treatment for hypertension (mean arterial blood pressure, greater than or equal to 110 mm Hg) in the 24 hours following surgery. In addition, patients in the morphine group had lower blood pressures in the 24 hours following surgery. These data suggest that sympathetic nervous system activity and not adrenal epinephrine or pituitary secretion of arginine vasopressin is responsible for the development of hypertension following aortic surgery. Furthermore, epidural narcotics appear to provide a means of attenuating this response.
(Invited) Graphene Synthesis and Transfer Improvements for Applications in the Semiconductor Industry (2017)

© The Electrochemical Society. A reliable CMOS compatible graphene integration route is still missing today. An overview of CVD graphene growth on Cu, Pt and Ge catalyst template wafers is given. Due to the high CVD graphene growth temperatures in combination with the necessity of a catalyst layer, a direct graphene growth on devices is unfeasible. As a result, a graphene transfer process to semiconductor devices is absolutely required. An overview of several graphene transfer approaches is given, starting with the standard wet etch based transfer. Next, a PVA based peeling transfer and the electrochemical bubble based transfer are described. Furthermore, the current transfer bottlenecks are identified. The paper ends with a discussion of the importance of using a passivation layer on the target wafer before transferring graphene and the implications of this passivation layer on the transfer process are outlined.
Relief of bowel-related symptoms with telotristat etiprate in octreotide refractory carcinoid syndrome: Preliminary results of a double-blind, placebo-controlled multicenter study. (2012)

4085 Background: Diarrhea associated with carcinoid syndrome has been attributed to tumor production of serotonin. Telotristat etiprate, (LX1032, LX1606), is an oral inhibitor of peripheral serotonin synthesis. This study explored the safety, tolerability, and efficacy of telotristat etiprate in carcinoid patients with octreotide-refractory diarrhea. Methods: Carcinoid patients with ≥4 bowel movements (BMs)/day on octreotide were randomized 3:1 to receive telotristat etiprate or placebo as double-blind treatment. Patients enrolled in sequential, escalating dose cohorts of 150, 250, 350, or 500 mg tid, followed by a 500 mg tid expansion cohort. Patients were followed for toxicity, 24-hr urinary 5-HIAA (u5-HIAA), BM frequency, and self-reported bowel-related symptoms. Subjects were asked “In the past 7 days, have you had adequate relief of your carcinoid syndrome bowel complaints such as diarrhea, urgent need to have a bowel movement, abdominal pain or discomfort?” Responses (yes or no) were analyzed as categorical variables. Results: 16 patients enrolled in the 4 escalating dose cohorts and 7 in the expansion cohort; 18 on telotristat etiprate and 5 on placebo. Median age: 62 yrs; mean 6.3 BMs/day (range, 4-10). AEs included primarily mild-moderate diarrhea, nausea, and abdominal discomfort. In treated subjects, adequate relief was reported as: Week 1 - 6/18 (33.3%), Week 2 - 5/16 (31.3%), Week 3 - 5/15 (33.3%), and Week 4 - 6/13 (46.0%). No placebo subjects reported improvement at any timepoint. Biochemical response (≥50%reduction in u5-HIAA) and BM response (≥30% reduction in daily BMs for 2 weeks) were associated with reporting of adequate relief. For evaluable telotristat etiprate-treated patients, 9/16 (56%) experienced a biochemical response and 5/18 (28%) experienced a clinical (BM) response; no placebo subjects achieved either biochemical or clinical response. Conclusions: Treatment with telotristat etiprate was associated with decreases in u5-HIAA and BM frequency, and with self-reported relief of bowel related symptoms. Treatment in an extension phase with open-label telotristat etiprate is ongoing.
ChemInform Abstract: REACTIONS OF KETENES WITH SULFILIMINES. SYNTHETIC ROUTES TO OXAZOLINONES AND INDOLINONES (1985)

Abstract Diphenylketen (I) reagiert mit (II) zu den Oxazolinonen (III), die zu (IV) reduziert werden.
A Topical Zinc Ionophore Blocks Tumorigenic Progression in UV‐exposed SKH‐1 High‐risk Mouse Skin (2017)

Nonmelanoma skin cancer (NMSC) is the most common malignancy in the United States representing a considerable public health burden. Pharmacological suppression of skin photocarcinogenesis has shown promise in preclinical and clinical studies, but more efficacious photochemopreventive agents are needed. Here, we tested feasibility of harnessing pharmacological disruption of intracellular zinc homeostasis for photochemoprevention in vitro and in vivo. Employing the zinc ionophore and FDA-approved microbicidal agent zinc pyrithione (ZnPT), used worldwide in over-the-counter (OTC) topical consumer products, we first demonstrated feasibility of achieving ZnPT-based intracellular Zn<sup>2+</sup> overload in cultured malignant keratinocytes (HaCaT-ras II-4; SCC-25) employing membrane-permeable fluorescent probes. Zinc overload was accompanied by induction of intracellular oxidative stress, associated with mitochondrial superoxide release as substantiated by MitoSOX Red™ fluorescence microscopy. ZnPT-induced cell death observable in malignant keratinocytes was preceded by induction of metal (MT2A), proteotoxic (HSPA6, HSPA1A, DDIT3, HMOX1) and genotoxic stress response (GADD45A, XRCC2) gene expression at the mRNA and protein levels. Comet analysis revealed introduction of formamidopyrimidine-DNA glycosylase (Fpg)-sensitive oxidative DNA lesions. In a photocarcinogenesis model (UV-exposed SKH-1 high-risk mouse skin), topical ZnPT administration post-UV caused epidermal zinc overload and stress response gene expression with pronounced blockade of tumorigenesis. Taken together, these data suggest feasibility of repurposing a topical OTC drug for zinc-directed photochemoprevention of solar UV-induced NMSC.
A High-Throughput Screening Identifies MICU1 Targeting Compounds (2020)

Mitochondrial Ca<sup>2+</sup> uptake depends on the mitochondrial calcium uniporter (MCU) complex, a highly selective channel of the inner mitochondrial membrane (IMM). Here, we screen a library of 44,000 non-proprietary compounds for their ability to modulate mitochondrial Ca<sup>2+</sup> uptake. Two of them, named MCU-i4 and MCU-i11, are confirmed to reliably decrease mitochondrial Ca<sup>2+</sup> influx. Docking simulations reveal that these molecules directly bind a specific cleft in MICU1, a key element of the MCU complex that controls channel gating. Accordingly, in MICU1-silenced or deleted cells, the inhibitory effect of the two compounds is lost. Moreover, MCU-i4 and MCU-i11 fail to inhibit mitochondrial Ca<sup>2+</sup> uptake in cells expressing a MICU1 mutated in the critical amino acids that forge the predicted binding cleft. Finally, these compounds are tested ex vivo, revealing a primary role for mitochondrial Ca<sup>2+</sup> uptake in muscle growth. Overall, MCU-i4 and MCU-i11 represent leading molecules for the development of MICU1-targeting drugs.
Perspectives on adaptive dynamical systems (2023)

Adaptivity is a dynamical feature that is omnipresent in nature, socio-economics, and technology. For example, adaptive couplings appear in various real-world systems like the power grid, social, and neural networks, and they form the backbone of closed-loop control strategies and machine learning algorithms. In this article, we provide an interdisciplinary perspective on adaptive systems. We reflect on the notion and terminology of adaptivity in different disciplines and discuss which role adaptivity plays for various fields. We highlight common open challenges, and give perspectives on future research directions, looking to inspire interdisciplinary approaches.
Resource Optimization for Service Chain Monitoring in Software-Defined Networks (2015)

Emerging services enabled by software-defined networking (SDN) and network function virtualization (NFV) are introducing new challenges to network monitoring. One such network service is "service chaining", where the complexity of the data path forwarding is coupled with the heterogeneity of service functions. This makes it extremely difficult to monitor and troubleshoot networks with a reasonable resource overhead. We propose a framework that can be applied for service chain monitoring. A monitoring hierarchy is defined, which converts a monitoring intent to monitoring zones and probes for on-demand monitoring. To minimize the cost of probe deployment, we design a heuristic algorithm that conducts dynamic pruning and search. We also identify the possibility for monitoring-rule consolidation when multiple probes are co-located, and introduce the use of Bloom Filters to optimize monitoring resource usage. Our performance evaluation shows reduced probe-deployment cost by our Tree Search algorithm in various settings, and significant memory savings by rule consolidation.
Serial Transient Elastography Examinations to Monitor Patients With Type 2 Diabetes: A Prospective Cohort Study (2020)

The prevalence and incidence of NAFLD in patients with type 2 diabetes are high. Although advanced fibrosis is common in this population, few patients progress to advanced fibrosis in 3 years. Future studies should define the optimal surveillance interval in patients with diabetes.
ChemInform Abstract: High Oxidation State Monopentamethylcyclopentadienyl Tungsten Methyl Complexes Including the First d0 Complex Containing a Highly Distorted Methylene Ligand, W(η5‐C5Me5)(CH3)3(CH2). (1987)

Abstract Addition of the dimeric chloro‐W compound (II), prepared as shown, to MeMgCl (III) yields the thermally stable tetragonal‐pyramidal tetramethyl derivative (IV).
Evidence for the presence of several phosphodiesterase isoforms in brown adipose tissue of Zucker rats: modulation of PDE2 by the fa gene expression (1999)

The present study was undertaken to characterise the phosphodiesterases (PDEs) present in brown adipose tissue (BAT) of Zucker rat pups and to determine whether the capacity for degradation of cyclic nucleotides was affected by the fatty genotype. Regardless of the genotype, PDE2-4 contributed to total PDE activity, the PDE3 activity equalling the sum of PDE2 and 4 activities. In fa/fa compared to Fa/fa rats, (a) PDE2 activity was significantly increased, (b) Western blot analysis of PDE2 revealed two signals at 71 and 105 kDa, with changes in protein being in good parallelism with changes in activity, (c) the PDE2 mRNA concentration was also significantly increased. In good agreement, the cGMP concentration was decreased in BAT from fa/fa pups.
Anti-KIT DNA aptamer-conjugated porous silicon nanoparticles for the targeted detection of gastrointestinal stromal tumors (2022)

Evaluation of Gastrointestinal Stromal Tumors (GIST) during initial clinical staging, surgical intervention, and postoperative management can be challenging. Current imaging modalities (<i>e.g.</i>, PET and CT scans) lack sensitivity and specificity. Therefore, advanced clinical imaging modalities that can provide clinically relevant images with high resolution would improve diagnosis. KIT is a tyrosine kinase receptor overexpressed on GIST. Here, the application of a specific DNA aptamer targeting KIT, decorated onto a fluorescently labeled porous silicon nanoparticle (pSiNP), is used for the <i>in vitro</i> & <i>in vivo</i> imaging of GIST. This nanoparticle platform provides high-fidelity GIST imaging with minimal cellular toxicity. An <i>in vitro</i> analysis shows greater than 15-fold specific KIT protein targeting compared to the free KIT aptamer, while <i>in vivo</i> analyses of GIST-burdened mice that had been injected intravenously (IV) with aptamer-conjugated pSiNPs show extensive nanoparticle-to-tumor signal co-localization (>90% co-localization) compared to control particles. This provides an effective platform for which aptamer-conjugated pSiNP constructs can be used for the imaging of KIT-expressing cancers or for the targeted delivery of therapeutics.
Digital Panel Assembly Methodologies and Applications for Compliant Sheet Components (2005)

This paper presents digital panel assembly (DPA) methodologies and applications for sheet component assembly in automotive body manufacturing processes. Core to DPA is the customized finite element analysis formulas we have developed, which simulates assembly processes and predicts assembly dimensions by taking into consideration the panel compliances. Two key analysis types of the DPA are presented, the deterministic analysis and variation analysis. We present a methodology to utilize the quadratic form of Taylor series expansion to approximate the assembly dimensions efficiently in variation simulation, and discuss its pros and cons versus the traditional Monte Carlo method under different modeling conditions. For either the deterministic or variation analysis, linear models (without contact, efficient but less accurate), and nonlinear models (with contact, less efficient but accurate) can be established. It is shown that the linear models are only valid when panels do not penetrate, and that the nonlinear models should generally be used for accurate assembly dimension prediction. Based on the DPA methodologies, a software tool called Elastic Assembly Variation Simulation (EAVS) is presented, followed by application case studies. The confidence intervals for variation analysis are also discussed.
Data from Loss of <i>ARID1A</i> Activates <i>ANXA1</i>, which Serves as a Predictive Biomarker for Trastuzumab Resistance (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Despite the substantial progress in the development of targeted anticancer drugs, treatment failure due to primary or acquired resistance is still a major hurdle in the effective treatment of most advanced human cancers. Understanding these resistance mechanisms will be instrumental to improve personalized cancer treatment.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Genome-wide loss-of-function genetic screens were performed to identify genes implicated in resistance to HER2/PI3K/mTOR targeting agents in HER2&lt;sup&gt;+&lt;/sup&gt; breast cancer cell lines. Expression and adjuvant trastuzumab response data from the HER2&lt;sup&gt;+&lt;/sup&gt; breast cancer trials FinHer and Responsify were used to validate our findings in patient series.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; We find that reduced &lt;i&gt;ARID1A&lt;/i&gt; expression confers resistance to several drugs that inhibit the HER2/PI3K/mTOR signaling cascade at different levels. We demonstrate that &lt;i&gt;ARID1A&lt;/i&gt; loss activates annexin A1 (&lt;i&gt;ANXA1&lt;/i&gt;) expression, which is required for drug resistance through its activation of AKT. We find that the AKT inhibitor MK2206 restores sensitivity of &lt;i&gt;ARID1A&lt;/i&gt; knockdown breast cancer cells to both the mTOR kinase inhibitor AZD8055 and trastuzumab. Consistent with these &lt;i&gt;in vitro&lt;/i&gt; data, we find in two independent HER2&lt;sup&gt;+&lt;/sup&gt; breast cancer patient series that high &lt;i&gt;ANXA1&lt;/i&gt; expression is associated with resistance to adjuvant trastuzumab–based therapy.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our findings provide a rationale for why tumors accumulate &lt;i&gt;ARID1A&lt;/i&gt; mutations and identify high &lt;i&gt;ANXA1&lt;/i&gt; expression as a predictive biomarker for trastuzumab-based treatment. Our findings also suggest strategies to treat breast cancers with elevated &lt;i&gt;ANXA1&lt;/i&gt; expression. &lt;i&gt;Clin Cancer Res; 22(21); 5238–48. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Stereotactic transplantation of a dopamine-producing capsule into the striatum for treatment of Parkinson disease: a preclinical primate study (2003)

These results suggest that the transplantation of encapsulated PC12 cells could be a safe and effective treatment modality for Parkinson disease in human patients.
Fractional Laser-assisted Hair Regrowth and Microneedling for the Treatment of Alopecia Areata: A Review (2019)

Alopecia areata (AA) affects approximately 2.1% of the population, with women being affected more often than men. Current therapies consisting of topical corticosteroids or intralesional injections are often the first choices for treatment, but are limited by unsatisfactory outcomes or risks to patients. Recently, fractional lasers and microneedling, with or without the addition of topical agents, have been examined as treatment options. A literature review was performed to evaluate the efficacy of fractional lasers in the treatment of AA. A total of six fractional lasers and two microneedling studies consisting of small prospective and retrospective studies, and case reports were reviewed. The number of trials and participants are limited, but evidence suggests that fractional lasers and microneedling may be effective therapeutic approaches when coupled with topical agents. Larger studies are required to better understand the effects of these treatment modalities for AA.
Spacer‐length‐dependent association in polymers with multiple‐hydrogen‐bonded end groups (2011)

Abstract Herein, we investigate the influence of spacer length on the homoassociation and heteroassociation of end‐functionalized hydrogen‐bonding polymers based on poly( n ‐butyl acrylate). Two monofunctional ureido‐pyrimidinone (UPy) end‐functionalized polymers were prepared by atom transfer radical polymerization using self‐complementary UPy‐functional initiators that differ in the spacer length between the multiple‐hydrogen‐bonding group and the chain initiation site. The self‐complementary binding strength ( K dim ) of these end‐functionalized polymers was shown to depend critically on the spacer length as evident from 1 H NMR and diffusion‐ordered spectroscopy. In addition, the heteroassociation strength of the end‐functionalized UPy polymers with end‐functionalized polymers containing the complementary 2,7‐diamido‐1,8‐naphthyridine (NaPy) hydrogen‐bond motif is also affected when the aliphatic spacer length is too short. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
eWLB package for millimeter wave application (2015)

In this paper we demonstrate the applicability of the eWLB (embedded Wafer Level Ball Grid Array) package for millimeter wave applications. Due to low parasitics the package offers excellent RF performance which is a key element for millimeter wave application. By use of thermo-balls we achieve excellent thermal behaviour. The thermo-balls are placed directly below the silicon die and enable best possible heat dissipation. In order to improve further thermal conductivity, we use backside cooling on system level. A redundant concept for package design ensures best reliability performance. We show the capability of the eWLB technology based on the example of an LTE (Long Term Evolution) backhaul component for point to point wireless connection at 60, 70 and 80 GHz. Small cell infrastructure in LTE backhaul applications becomes more and more important due to explosive growth in wireless data traffic. Conventional market in this millimeter wave application is dominated by high-effort bare die and high-cost RF module solutions. Our unique eWLB package will enable our customers to use millimeter wave devices easily in a standard SMD (Surface-Mounting Device) line.
Demonstrating the benefits of a multidisciplinary aerodigestive program (2019)

4 Laryngoscope, 130:521-525, 2020.
Hydrogen-transfer catalyzed by half-sandwich Ru(ii) aminophosphine complexesElectronic supplementary information (ESI) available: experimental details and NMR data for 1c and 2c. See http://www.rsc.org/suppdata/dt/b1/b104128m/ (2001)

The syntheses of and catalytic studies on some Ru(II) complexes bearing the aminophosphine ligands N,N-dimethyl-2-diphenylphosphinoethylamine (PN), optically pure (RC,Spl)-2- {1-(N,N-dimethylamino)ethyl}-1-diphenylphosphinoferrocene (PPFA), and N,N-dimethyl-2-diphenylphosphinoaniline (DBD) are described, [RuCp(CH3CN)3]+ reacts with these ligands to give the cationic complexes [RuCp(PN-κN,κP)(CH3CN)]+ (1a), [(SRu,RC,Spl)-RuCp(PPFA-κN,κP)(CH3CN)]+ (1b), and [RuCp(DBD-κN,κP )(CH3CN)]+ (1c), respectively, in high yields. From these, in turn, the residual CH3CN ligand can be replaced by Br− upon addition of NEt4Br in CH2Cl2, resulting in the formation of the neutral complexes RuCp(PN)Br (2a), (SRu,RC,Spl)-RuCp(PPFA)Br (2b), and RuCp(DBD)Br (2c), again in good yields. Similarly, [Ru(η6-p-cymene)Cl2]2 reacts with 1 equiv. of PN or PPFA to give Ru(η6-p-cymene)(PN-κP)Cl2 (3a) and Ru(η6-p-cymene)(PPFA-κP)Cl2 (3b). Furthermore, treatment of 3 with TlCF3SO3 in THF at room temperature affords the cationic complexes [Ru(η6-p-cymene)(PN-κN,κP)Cl]CF3SO3 (4a) and [(RRu,RC,Spl)-Ru(η6-p-cymene)(PPFA-κN,κP)Cl]CF3SO3 (4b). The absolute configuration at the metal center of 2b and 4b′ (BPh4− salt of 4b) was determined by X-ray crystallography. Catalytic studies were performed with the racemic complexes 1a, 2a, 2c, and 4a and the diastereopure complexes 1b, 2b, and 4b. All of these proved to be excellent precatalysts for the transfer hydrogenation of acetophenone and derivatives thereof, and cyclohexanone. With the enantiomerically pure systems 2b and 4b, only racemic products were obtained. This testifies to the hemilabile nature of the aforementioned aminophosphine ligands giving transient κ-P-bonding coordination. Since diastereoface selection of incoming substrates is based on the planar chirality of the ferrocene moiety, rather than the metal centered chirality, no enantioselective reaction takes place.
Parallel Implementation Technique of Digital Equalizer for Ultra-High-Speed Wireline Receiver (2018)

This paper presents a parallel implementation technique of digital equalizer for high-speed wireline serial link receiver (RX). In wireline RX, inter-symbol interference (ISI) is mitigated by continuous-time linear equalizer, and the remaining ISI is cancelled out by decision-feedback equalizer (DFE). However, due to the existence of feedback loop in DFE, there is no trivial way to parallelize it, making it difficult to be realized in digital circuits for wireline RX based on analog-to-digital converter (ADC) with ≥ 56 Gb/s data rate. In this work, convolution theorem is applied for achieving parallel digital equalizer implementation. The digital equalizer datapath consists of discrete Fourier transform (DFT) core, inverse-DFT (IDFT) core, complex multipliers between DFT and IDFT cores, and overlap-add circuit. Design considerations for low-area VLSI implementation of such architecture is discussed.
<title>Partial response modulation codes for electron trapping optical memory (ETOM)</title> (1995)

We consider the problem of coding for a recording channel. Traditional magnetic or optical channels employ saturation recording, where the input to the channel is a two-level waveform. New optical recording channels have been developed that support unsaturated, M-ary (M &gt;= 3) signal levels. In this paper we consider the analysis and design of partial response codes for these channels. Comparisons are made with M-ary runlength limited codes. The partial response codes presented here achieve the largest known storage density and achieve a coding gain of 3-6 dB over M-ary runlength limited codes.