gebhart/patrepeval huggingface dataset:
Rapid Slicing Algorithm Based on Geometry Continuity for RPM (2000)

Slicing of STL Model is a fundamental data transfer task for RPM. The existing slicing algorithm based on topology information extracted from STL has high efficiency in searching intersecting facets,however, due to global topology information extraction, a greater amount of inner memory is occupied,while a lot of time is needed for this operation. This paper proposes an idea of slicing on the basis of geometry continuity. By generating new intersecting facets table of each slicing plane and extracting only topology information of the current slicing plane, inner memory is remarkably saved, while the extracting time is also saved to some extent. Besides these merits, incremental method is used to generate slice contours instead of the previous one getting each slicing contour separatly, which contributes to improvement of slicing efficiency futher.
Loss of cerebral regulation during cardiac output variations in focal cerebral ischemia (1992)

Focal cerebral ischemia was induced in anesthetized macaque monkeys by unilateral middle cerebral artery occlusion. The effect of blood volume expansion by a colloid agent and subsequent exsanguination to baseline cardiac output (CO) on local cerebral blood flow (CBF) was measured by the hydrogen clearance technique in both ischemic and nonischemic brain regions. Cardiac output was increased to maximum levels (159% +/- 92%, mean +/- standard error of the mean) by blood volume expansion with the colloid agent hetastarch, and was then reduced a similar amount (166% +/- 82%) by exsanguination during the ischemic period. Local CBF in ischemic brain regions varied directly with CO, with a correlation coefficient of 0.89 (% change CBF/% change CO), while CBF in nonischemic brain was not affected by upward or downward manipulations of CO. The difference in these responses between ischemic and nonischemic brain was highly significant (p less than 0.001). The results of this study show a profound loss of regulatory control in ischemic brain in response to alterations in CO, thereby suggesting that blood volume variations may cause significant changes in the intensity of ischemia. It is proposed that CO monitoring and manipulation may be vital for optimum care of patients with acute cerebral ischemia.
A multi-modal approach to the management of bypass graft failure (1998)

Bypass graft failure is an unsolved problem in the contemporary treatment of peripheral arterial occlusion. Thrombolysis of a failed bypass graft is performed with instillation of plasminogen activators directly into the substance of the thrombus. Thrombolytic techniques can restore the bypass graft to its pre-occlusive state, clearing the inflow and outflow tracts of propagated thrombus and unmasking the causative lesion responsible for graft occlusion. Open surgery, or an endovascular modality, can then be employed to directly address these lesions. Recent randomized trials have demonstrated the safety and efficacy of a thrombolytic treatment strategy when the graft occlusion is acute, that is, when the patient presents within 2 weeks of the event. The appropriate management of the patient with an acutely occluded bypass graft includes thrombolysis, endovascular modalities and open surgery, employed in conjunction, to improve patient outcome over that observed with an immediate operation alone.
ChemInform Abstract: Direct Arylation of Imidazo[1,5‐a]azines Through Ruthenium and Palladium Catalysis. (2015)

Abstract The imidazo[1,5‐a]azine system is described as directing group for site‐selective Ru‐catalyzed C‐H arylation at the ortho‐position with aryl halides as coupling partners.
Reliability of percent distribution of power of the electrogastrogram in recognizing gastric electrical uncoupling (1997)

The aim of this study was to examine the reliability of percent distribution of electrogastrographic (EGG) power in recognizing gastric electrical uncoupling. Sixteen anaesthetized dogs underwent laparotomy and implantation of six pairs of stainless-steel wire electrodes. Distal stomach was measured and three sections with approximately equal lengths were defined. Two pairs of electrodes were implanted in each section. Eight-channel EGG was also recorded. Three separate half-hour recordings were made: in the basal state; after a full circumferential separation of the distal antral section from the rest; after a second circumferential cut completely separating the middle from the proximal sections. EGG digital power spectra were split into three frequency ranges and dynamics of percent distribution of power was statistically examined. After the first cut, changes in the percent distribution of EGG power in the normal range were not significant (p = 0.2). Significant changes in the low range were noted (p < 0.05) and changes in the high range were borderline nonsignificant (p = 0.056). After the second cut, changes in percent distribution in the normal and the high range became significant (p < 0.01) while changes in the low range were insignificant (p = 0.075). Severe uncoupling was reflected in EGG by significant changes in the high-frequency range without internal tachygastria necessarily being present.
Compact Design of Dual-Band Circular Polarized Microstrip Antenna with Single Feed (2019)

A novel and compact dual band dual sense circularly polarized microstrip patch antenna with single coaxial feed has been reported in the present work. The key idea of generating dual band circular polarisation (CP) is the integration of a square patch with corner truncation and a smaller concentric circular patch with double slits. The first resonance is provided by the larger patch whose corner truncation generates two orthogonal modes. The inner patch controls the higher-order resonance with the CP contributed by two narrow slits. The higher order resonating frequency can be monitored by controlling the dimensions of the circle and the slits. The antenna provides the CP in two orthogonal planes with two different sense of polarisation. The lower order CP is of left-handed orientation, whereas the higher order shows right-handed polarization. The cross-polarization level is also found to be very low.
Single-cell RNA-sequencing reveals pre-meiotic X-chromosome dosage compensation in Drosophila testis (2021)

Abstract Dosage compensation (DC) is a mechanism by which X chromosome transcription is equalized in the somatic cells of both males and females. In male fruit flies, expression levels of the X-chromosome are increased two-fold to compensate for their single X chromosome. In testis, dosage compensation is thought to cease during meiosis, however, the timing and degree of the resulting transcriptional suppression is difficult to separate from global meiotic downregulation of each chromosome. To address this, we analyzed testis single-cell RNA-sequencing (scRNA-seq) data from two Drosophila melanogaster strains. We found evidence that the X chromosome is equally transcriptionally active as autosomes in somatic and pre-meiotic cells, and less transcriptionally active than autosomes in meiotic and post-meiotic cells. In cells experiencing dosage compensation, close proximity to MSL (male-specific lethal) chromatin entry sites (CES) correlates with increased X chromosome transcription. We found low or undetectable level of germline expression of most msl genes, mle, roX1 and roX2 via sequencing or RNA-FISH, and no evidence of germline nuclear roX1/2 localization. Our results suggest that, although DC occurs in somatic and premeiotic germ cells in Drosophila testis, there might be non-canonical factors involved in the dosage compensation. The single-cell expression patterns and enrichment statistics of detected genes can be explored interactively in our database: https://zhao.labapps.rockefeller.edu/gene-expr/ .
Evaluation of IPv6 Transition Mechanisms for Unmanaged Networks (2004)

This document analyzes issues involved in the transition of "unmanaged networks" from IPv4 to IPv6. Unmanaged networks typically correspond to home networks or small office networks. A companion paper analyzes out the requirements for mechanisms needed in various transition scenarios of these networks to IPv6. Starting from this analysis, we evaluate the suitability of mechanisms that have already been specified, proposed, or deployed.
The significance of oxygen-deficient defects to the photosensitivity of hydrogen-loaded germano-silicate glass (1999)

It is widely believed that oxygen-deficient defects in germano-silicate glass play a crucial role in the photosensitivity of this material to ultraviolet radiation. In this article, it is shown that germano-silicate glass that is defect-free and hydrogen-loaded also exhibits photosensitivity to 248 nm light. In fact, photosensitivity in defect-free germano-silicate glass is shown to require the presence of hydrogen. However, oxygen-deficient defects increase the photosensitivity of germano-silicate glass to light with a wavelength of 248 nm, in both the hydrogen-free and the hydrogen-loaded case. Comparisons are made among four types of otherwise identical germano-silicate glass. Each glass sample studied either does or does not contain oxygen-deficient defects and, each glass sample either does or does not contain hydrogen.
Kinetics of Fatty Acid Interactions with Fatty Acid Binding Proteins from Adipocyte, Heart, and Intestine (1996)

Rate constants for the interaction of fatty acids (FA) with fatty acid binding proteins (FABP) from adipocyte (A-FABP), heart (H-FABP), and intestine (I-FABP) were determined by using stopped-flow fluorometry and ADIFAB, the fluorescent probe of free fatty acids (FFA), or a new FFA probe, ADIFAB2, constructed by derivatizing with acrylodan the Leu72 --> Ala mutant of I-FABP. ADIFAB2, because its binding affinities are about 10-fold greater than ADIFAB, was found to be more accurate for monitoring the kinetics of the higher affinity reactions. On- (kappa on) and off- (kappa off) rate constants were determined as a function of temperature. Our results reveal that in all cases the FA-FABP equilibrium is achieved within 2 s at 37 degrees C and within 20 s at 10 degrees C. Off-rate constants varied by about 10-fold among the different underivatized FABPs; kappa off values were smallest for H-FABP and largest for A-FABP, while kappa on values for these proteins generally varied by less than 2-fold. The results show that the previously reported larger affinities of I- and H-FABPs as compared to A-FABP are primarily a reflection of larger kappa on values for I-FABP and smaller kappa off values for H-FABP. Eyring transition state theory was used to evaluate the activation thermodynamic parameters for both on- and off-reactions and the results show that in virtually all cases the rate-limiting steps are predominantly enthalpic. Activation free energies for binding to ADIFAB are generally composed of about 8 kcal/mol unfavorable enthalpy and about a 1 kcal/mol favorable entropic contribution. For the underivatized FABPs the activation free energies are all about 7 +/- 0.3 kcal/mol, suggesting that the transition state for entering or leaving the binding site involves a common protein structural change. We suggest that entering or leaving the FABP binding cavity involves similar mechanisms for all 3 FABPs and may involve amino acid residues located within the portal regions of these proteins.
Perception of strength and power of realistic male characters (2015)

We investigated the influence of body shape and pose on the perception of physical strength and social power for male virtual characters. In the first experiment, participants judged the physical strength of varying body shapes, derived from a statistical 3D body model. Based on these ratings, we determined three body shapes (weak, average, and strong) and animated them with a set of power poses for the second experiment. Participants rated how strong or powerful they perceived virtual characters of varying body shapes that were displayed in different poses. Our results show that perception of physical strength was mainly driven by the shape of the body. However, the social attribute of power was influenced by an interaction between pose and shape. Specifically, the effect of pose on power ratings was greater for weak body shapes. These results demonstrate that a character with a weak shape can be perceived as more powerful when in a high-power pose.
ChemInform Abstract: Iron‐Mediated Complete Chirality Transfer in Allylic Substitutions. Efficient Synthesis of (‐)‐(S)‐Myoporone. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Challenges of damascene etching for copper interconnect (1999)

Dual damascene patterning is essential for the integration of copper into a high performance interconnect, hence the etching process becomes the most important challenge. This paper described the work on the dual damascene etching. The three most common schemes for patterning the dual damascene structure are trench-first, via-first (also known as counter-bore) and self-aligned etchings. Although only self- aligned etching requires the insertion of a stop layer, the stop layer is crucial to all schemes for a better control of the etching uniformity. The impact of using a stop layer with every dual damascene scheme was investigated. Lithography plays an important role in damascene etching. The use of negative-tone photoresist for metal trench masking and the challenge of forming a residue-free damascene structure in the presence of a bottom anti- reflecting coating were discussed.
All-pole model parameter estimation for voiced speech (2002)

To overcome the limitations of linear prediction based all-pole models of voiced speech, we present some new methods for obtaining the parameters of all-pole filters. In particular, we present a technique based on the minimum variance distortionless response (MVDR) spectrum estimation method. With a sufficient filter order, MVDR filters model voiced speech formants exactly. Utilizing a property of MVDR all-pole filters, we present a technique for obtaining low order perceptually weighted all-pole filters. These new all-pole models provide superior modeling of medium pitch and high pitch voiced speech.
Studies on the penetration rate and extent of formaldehyde releasing properties of some biocides (1995)

American Contact Dermatitis Society Annual Meeting Abstracts: February 3, 1995 New Orleans, LA: PDF Only
Underlying mechanism for suppression of vascular smooth muscle cells by green tea polyphenol EGCG released from biodegradable polymers for stent application (2010)

Epigallocatechin-3-O-gallate (EGCG), the predominant catechin from tea, is known to exert a variety of cardiovascular beneficial effects by affecting the activity of receptor and signal transduction kinases. In this study, we investigated the suppressive effects of EGCG released from biodegradable poly(L-lactide-co-ε-caprolactone, PLCL) films on the proliferation, cell cycle progression and matrix metalloproteinase-2 (MMP-2) expression of vascular smooth muscle cells (VSMCs). The involvement of phosphorylated Akt (pAkt) and nuclear factor-κB (pNF-κB) as well as the internalization of EGCG into VSMCs was also examined as underlying mechanisms for EGCG-mediated VSMC inhibition. The proliferation of canine aortic SMCs (CASMCs) on EGCG-releasing PLCL (E-PLCL) was significantly inhibited. The culture of CASMCs on E-PLCL resulted in induction of cell cycle arrest at G(0)/G(1) phase and inactivation of pAkt, leading to subsequent apoptosis. Active MMP-2 expression was directly lowered by EGCG released from E-PLCL and indirectly inhibited by the EGCG-mediated suppression of pNF-κB. We also observed the incorporation of fluorescein isothiocyanate-conjugated EGCG into the cytoplasm of CASMCs and its further nuclear translocation, which could lead to the interruption of the exogenous signals directed to genes responsible for cellular responses of CASMCs. Taken together, the attenuated responses of VSMCs to E-PLCL were shown to be mediated through the suppression of pNF-κB, pAkt and each subsequent target genes or proteins by EGCG incorporated into the cells.
Ion Transport in Pendant and Backbone Polymerized Ionic Liquids (2019)

Polymerized ionic liquids (PILs) are single-ion conductors in which one of the ionic species is tethered to the polymer chain while the other is free to be transported. The ionic species can either be directly incorporated into the polymeric backbone (backbone PILs) or placed as pendant groups to the chain (pendant PILs). Here, we examined the morphology, conductivity, and rheology of imidazolium-based pendant and backbone PILs. We found that pendant PILs yielded higher ionic conductivity when scaled to Tg, but backbone PILs exhibited higher ionic conductivity on an absolute temperature scale, likely because of differences in the Tgs of the two systems. We also found that ion transport for backbone PILs was coupled to the segmental dynamics below Tg, where the decoupling of ionic conductivity from segmental relaxation was observed for pendant PILs. The results of this study will help the community to better understand the role of the PIL structure on conductivity to work toward the ultimate goal of designing high-performance solid polymer electrolytes.
Homogeneity Quantification Method and its Application to Microstructure Assessment (2014)

Abstract In this work, a method to precisely define and quantify homogeneity of microstructures is proposed. Said method is based on an interpretation of the Gini index and it was developed specifically for microstructure homogeneity assessments. Object homogeneity and region homogeneity are examples of parameters developed to describe different aspects of homogeneity in micrographs. Using these parameters, the homogeneities of Al-Si casting alloys and cast iron have been evaluated. The method can be adapted and combined with other techniques to fit the requirements of a given study case. Further applications of the method are discussed.
Computationally efficient confidence intervals for cross-validated area under the ROC curve estimates (2015)

In binary classification problems, the area under the ROC curve (AUC) is commonly used to evaluate the performance of a prediction model. Often, it is combined with cross-validation in order to assess how the results will generalize to an independent data set. In order to evaluate the quality of an estimate for cross-validated AUC, we obtain an estimate of its variance. For massive data sets, the process of generating a single performance estimate can be computationally expensive. Additionally, when using a complex prediction method, the process of cross-validating a predictive model on even a relatively small data set can still require a large amount of computation time. Thus, in many practical settings, the bootstrap is a computationally intractable approach to variance estimation. As an alternative to the bootstrap, we demonstrate a computationally efficient influence curve based approach to obtaining a variance estimate for cross-validated AUC.
Effects of nonlinear refractive index on few-cycle PW-class OPCPA (2011)

We present here simulations for an OPCPA laser design similar to the Petawatt Field Synthesizer (PFS), which aims to deliver pulses with 5 fs and 3 J energy. Our simulations typically include the effects of depletion, diffraction, walk-off, and dispersion, with the possibility to take multiple second-order nonlinear interactions (e.g. parasitic SHG of the pump) as well as quantum noise and nonlinear refractive index effects into consideration.
CCN2 Suppresses Catabolic Effects of Interleukin-1β through α5β1 and αVβ3 Integrins in Nucleus Pulposus Cells (2014)

The objective of the study was to examine the regulation of CCN2 by inflammatory cytokines, IL-1β, and TNF-α and to determine whether CCN2 modulates IL-1β-dependent catabolic gene expression in nucleus pulposus (NP) cells. IL-1β and TNF-α suppress CCN2 mRNA and protein expression in an NF-κB-dependent but MAPK-independent manner. The conserved κB sites located at -93/-86 and -546/-537 bp in the CCN2 promoter mediated this suppression. On the other hand, treatment of NP cells with IL-1β in combination with CCN2 suppressed the inductive effect of IL-1β on catabolic genes, including MMP-3, ADAMTS-5, syndecan 4, and prolyl hydroxylase 3. Likewise, silencing of CCN2 in human NP cells resulted in elevated basal expression of several catabolic genes and inflammatory cytokines like IL-6, IL-4, and IL-12 as measured by gene expression and cytokine protein array, respectively. Interestingly, the suppressive effect of CCN2 on IL-1β was independent of modulation of NF-κB signaling. Using disintegrins, echistatin, and VLO4, peptide inhibitors to αvβ3 and α5β1 integrins, we showed that CCN2 binding to both integrins was required for the inhibition of IL-1β-induced catabolic gene expression. It is noteworthy that analysis of human tissues showed a trend of altered expression of these integrins during degeneration. Taken together, these results suggest that CCN2 and inflammatory cytokines form a functional negative feedback loop in NP cells that may be important in the pathogenesis of disc disease.
Regional stiffening with aging in tibialis anterior tendons of mice occurs independent of changes in collagen fibril morphology (2011)

The incidence of tendon degeneration and rupture increases with advancing age. The mechanisms underlying this increased risk remain unknown but may arise because of age-related changes in tendon mechanical properties and structure. Our purpose was to determine the effect of aging on tendon mechanical properties and collagen fibril morphology. Regional mechanical properties and collagen fibril characteristics were determined along the length of tibialis anterior (TA) tendons from adult (8- to 12-mo-old) and old (28- to 30-mo-old) mice. Tangent modulus of all regions along the tendons increased in old age, but the increase was substantially greater in the proximal region adjacent to the muscle than in the rest of the tendon. Overall end-to-end modulus increased with old age at maximum tendon strain (799 ± 157 vs. 1,419 ± 91 MPa) and at physiologically relevant strain (377 ± 137 vs. 798 ± 104 MPa). Despite the dramatic changes in tendon mechanical properties from adulthood to old age, collagen fibril morphology and packing fraction remained relatively constant in all tendon regions examined. Since tendon properties are influenced by their external loading environment, we also examined the effect of aging on TA muscle contractile properties. Maximum isometric force did not differ between the age groups. We conclude that TA tendons stiffen in a region-dependent manner throughout the life span, but the changes in mechanical properties are not accompanied by corresponding changes in collagen fibril morphology or force-generating capacity of the TA muscle.
Evaluation of Near-UV/blue Aerosol Optical Thickness Retrieval from Airborne Hyperspectral Imagery (2006)

An aerosol retrieval algorithm is currently under development in scope of the upcoming APEX hyperspectral imager. It will be able to close the gap between global remote sensing and one-dimensional in situ measurements of atmospheric particles. This paper presents a feasibility study of the proposed APEX aerosol retrieval approach for hyperspectral imagery with high spatial resolution. The extraction of a sample aerosol optical thickness is done by fitting radiation transfer model results to measured at-sensor radiances at two near-UV/blue bands (394 and 404 nm) from the PHILLS imager. The PHILLS hyperspectral data are used to simulate the APEX Visible Near- Infrared detector and comprehend a dark surface reference target to avoid most uncertainties from the surface reflection contribution.