gebhart/patrepeval huggingface dataset:
Cloud object storage based Continuous Data Protection(cCDP) (2015)

Continuous Data Protection (CDP) enables recoverability to any point in time (time travel) facilitated via journaling of every write made by a system to disk. Stringent storage performance and capacity requirements for journaling make CDP a very high cost solution leading to limited adoption. In this work we first explore the feasibility of building such a CDP function on top of cheap commodity storage exposed via cloud object stores. Based on this analysis, we propose cCDP - a Cloud Continuous Data Protection framework that efficiently combines cloud object stores with edge caching to address requirements of low cost, high capacity, low latency and high storage throughput. cCDP with careful tuning can not only meet but surpasses the write throughput and latency requirements of CDP with minimal buffer overheads (<; 1%). Recovery lookup performance (Identification & Ordering) of cCDP with hybrid data layout is within 28% of Btree based temporal data layout and is about 52.7% better than the naive data layout with name encoding with significantly lower edge buffer and write throughput overheads than the Btree based temporal data layout.
Correction: Corrigendum: PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA (2017)

Nature Communications 8: Article number: 15110 (2017); Published: 27 Apr 2017; Updated: 13 Jun 2017 In this Article, the antibody ‘BG4’ is consistently referred to incorrectly as ‘hf2’. These errors appear in the Results and Methods. Additionally, the Article incorrectly cites reference 52 in the sentences ‘A recent study described hf2, an engineered single-chain antibody specific for G4 DNA52’ and ‘pSANG10-3F-BG4 (Addgene 55756)52 was transformed into….
Hydrophobic benzyl amines as supports for liquid-phase C-terminal amidated peptide synthesis: application to the preparation of ABT-510 (2015)

C-terminal amidation is one of the most common modification of peptides and frequently found in bioactive peptides. However, the C-terminal modification must be creative, because current chemical synthetic techniques of peptides are dominated by the use of C-terminal protecting supports. Therefore, it must be carried out after the removal of such supports, complicating reaction work-up and product isolation. In this context, hydrophobic benzyl amines were successfully added to the growing toolbox of soluble tag-assisted liquid-phase peptide synthesis as supports, leading to the total synthesis of ABT-510 (2). Although an ethyl amide-forming type was used in the present work, different types of hydrophobic benzyl amines could also be simply designed and prepared through versatile reductive aminations in one step. The standard acidic treatment used in the final deprotection step for peptide synthesis gave the desired C-terminal secondary amidated peptide with no epimerization.
Shape‐Memory Effect by Specific Biodegradable Polymer Blending for Biomedical Applications (2014)

Specific biodegradable polymers having shape-memory properties through "polymer-blend" method are investigated and their shape-switching in body temperature (37 °C) is characterized. Poly(L-lactide-co-caprolactone) (PLCL) and poly(L-lactide-co-glycolide) (PLGA) are dissolved in chloroform and the films of several blending ratios of PLCL/PLGA are prepared by solvent casting. The shape-memory properties of films are also examined using dynamic mechanical analysis (DMA). Among the blending ratios, the PLCL50/PLGA50 film shows good performance of shape-fixity and shape-recovery based on glass transition temperature. It displays that the degree of shape recovery is 100% at 37 °C and the shape recovery proceeds within only 15 s. In vitro biocompatibility studies are shown to have good blood compatibility and cytocompatibility for the PLCL50/PLGA50 films. It is expected that this blended biodegradable polymer can be potentially used as a material for blood-contacting medical devices such as a self-expended vascular polymer stents and vascular closure devices in biomedical applications.
Copolymerization of VDF and HFP in Supercritical Carbon Dioxide: A Robust Approach for Modeling Precipitation and Dispersion Kinetics (2011)

Abstract A kinetic model is developed for the heterogeneous free‐radical copolymerization of vinylidene fluoride and hexafluoropropylene in supercritical CO 2 . The model accounts for polymerization in both the dispersed (polymer‐rich) phase and in the continuous (polymer‐free) supercritical phase, for radical interphase transport, diffusion limitations, and chain‐length‐dependent termination in the polymer‐rich phase. A parameter evaluation strategy is developed and detailed to estimate most of the kinetic parameters a priori while minimizing their evaluation by direct fitting. The resulting model predictions compare favorably with the experimental results of conversion and MWD at varying monomer feed composition, monomer concentration, interphase area, and pressure of the system. magnified image
Iron-Catalyzed Synthesis of Sulfur-Containing Heterocycles (2016)

An iron-catalyzed synthesis of sulfur- and sulfone-containing heterocycles is reported. The method is based on the cyclization of readily available substrates and proceeded with high efficiency and diastereoselectivity. A variety of sulfur-containing heterocycles bearing moieties suitable for subsequent functionalization are prepared. Illustrative examples of such postcyclization modifications are also presented.
A reconfigurable 8 GOP ASIC architecture for high-speed data communications (2000)

A flexible and reconfigurable signal processing ASIC architecture has been developed, simulated, and synthesized. The proposed architecture compares favorably to classical DSP and FPGA solutions. It differs from general-purpose reconfigurable computing (RC) platforms by emphasizing high-speed application-specific computations over general-purpose flexibility. The proposed architecture can he used to realize any one of several functional blocks needed for the physical layer implementation of data communication systems operating at symbol rates in excess of 125 Msymbols/s. Multiple instances of a chip based on this architecture, each operating in a different mode, can be used to realize the entire physical layer of high-speed data communication systems. The architecture features the following modes (functions): real and complex FIR/IIR filtering, least mean square (LMS)-based adaptive filtering, discrete Fourier transforms (DFT), and direct digital frequency synthesis (DDFS) at up to 125 Msamples/s. All of the modes are mapped onto a common, regular data path with minimal configuration logic and routing. Multiple chips operating in the same mode can be cascaded to allow for larger blocks.
A Framework for Improving the Quality of Research in the Biological Sciences (2016)

The American Academy of Microbiology convened a colloquium to discuss problems in the biological sciences, with emphasis on identifying mechanisms to improve the quality of research. Participants from various disciplines made six recommendations: (i) design rigorous and comprehensive evaluation criteria to recognize and reward high-quality scientific research; (ii) require universal training in good scientific practices, appropriate statistical usage, and responsible research practices for scientists at all levels, with training content regularly updated and presented by qualified scientists; (iii) establish open data at the timing of publication as the standard operating procedure throughout the scientific enterprise; (iv) encourage scientific journals to publish negative data that meet methodologic standards of quality; (v) agree upon common criteria among scientific journals for retraction of published papers, to provide consistency and transparency; and (vi) strengthen research integrity oversight and training. These recommendations constitute an actionable framework that, in combination, could improve the quality of biological research.
In Vivo Cardiac Diffusion-Weighted Magnetic Resonance Imaging (2012)

This study demonstrates that IVIM is technically feasible in vivo and reports for the first time the perfusion fraction, f, and the diffusion coefficients, D and D*, for the cardiac DWI of healthy volunteers. Motion-induced signal loss, which is the main problem associated with cardiac DWI, could be avoided with the combined use of sliding acquisition during the cardiac cycle and image postprocessing with the PCATMIP algorithm. This study provides new perspectives for perfusion imaging without a contrast agent and demonstrates that IVIM parameters can act as promising tools to further characterize microvascular abnormalities or dysfunction.
Using Hybrid Propulsion Autonomous Marine Vehicles to Better Characterize Geomagnetic Fields Offshore (2017)

Abstract We present a study conducted to develop and validate new capabilities for offshore geomagnetic surveying that employs the autonomous marine vehicle (AMV) to map the crustal magnetic field and monitor disturbance fields surrounding offshore drill sites. Knowledge of geomagnetic field direction and strength in the wellbore are essential parameters needed for directional drilling. To compute wellbore azimuth, the directional driller compares the magnetic field measurement provided by the measurement-while-drilling (MWD) tool with the geomagnetic field reference data to position the wellbore in real time while drilling. Correction for variations in the disturbance field is essential for accurate mapping of the crustal geomagnetic field. Unfortunately, land-based stations are not ideal for mapping the disturbance field in the offshore because of the distance of the station from the measurement site and the different electrical conductivity of the subsurface. To address the need for improved measurement of the disturbance field in offshore surveys, this study also investigated whether the new-generation, hybrid, wave- and electric-thruster powered AMV is suitable for use as a "base station" to monitor time variations of the geomagnetic disturbance field. To conduct the study, we equipped two hybrid AMVs with towed marine magnetometers. Highly sensitive sensors established the minimum required separation between the AMV's electric thruster and the magnetic sensor payload. For validation as a base station, data collected by the vehicles from May 11 to May 14, 2015, was analyzed and compared with data obtained from the USGS Honolulu Geomagnetic Observatory (HON). To then evaluate the survey measurement system offshore, we compared data from a previous 2013 wave-powered AMV geomagnetic survey (Poedjono et al., 2015) with repeat data of the main, tie, and perimeter lines newly collected by the AMVs in this 2015 study. Our results show that the AMV is ideally suited to carry out geomagnetic surveys in offshore remote locations, and a second AMV circulating at a fixed location provides a more accurate base station than a land-based station. The hybrid AMV offers distinct advantages for geomagnetic data collection in offshore environments. The low cost compared to a seaborne or airborne vehicle allows AMVs to be deployed in tandem and collect data repeatedly over predefined areas, yielding accurate measurements to determine the disturbance and crustal magnetic fields. Use of the AMV solves the long-standing problem of how to accurately map the previously unknown geomagnetic reference field in offshore locations.
Ellipses from triangles (2014)

We present an ellipse finding and fitting algorithm that uses points and tangents, rather than just points, as the basic unit of information. These units are analyzed in a hierarchy: points with tangents are paired into triangles in the first layer and pairs of triangles in the second layer vote for ellipse centers. The remaining parameters are estimated via robust linear algebra: eigen-decomposition and iteratively reweighed least squares. Our method outperforms the state-of-the-art approach in synthetic images and microscopic images of cells.
Autonomous Emergency Braking: A System-of-Systems perspective (2013)

In June 2012 the Ratings Group of EURO-NCAP published a strategic roadmap of the NCAP organization about the required safety features of new cars up to the year 2016. According to this roadmap Autonomous Emergency Braking Systems (AEBS) to detect and protect pedestrians should be deployed on a wide scale in new cars by the year 2016. In a car equipped with an AEBS there are two autonomous systems that compete for the control over the car, the human driver and the AEBS. In this paper we analyze the coordination of these two autonomous subsystems from the perspective of System-of-Systems in order to avoid the emergence of detrimental behavior and elaborate on the dependability mechanisms required to ensure safe operation.
The development of a reference database with the Topcon 3D OCT-1 Maestro (2018)

The overall normal thickness values reported with Topcon 3D OCT-1 Maestro were like those studies with OCT from different manufactures. The reference limits at the 1st, 5th, 95th, and 99th percentile points establish the thresholds for the quantitative comparison of the cpRNFL and the macula in the human retina to a database of known healthy subjects.
Selected Free Radical Reactions (2020)

Many useful bond-forming reactions and functional group manipulations involve free radicals. This chapter discusses selected free radical reactions. It covers radical reactions initiated by chemical means, photoredox catalysts and electrochemical methods. Photoredox catalysis emerged as a powerful tool to induce or accelerate chemical transformations via single-electron transfer events. The introduction of iridium- and ruthenium-based photoredox catalysts has opened up new pathways into radical formation from visible light. Electrochemistry provides another synthetic tool for performing single-electron transfer redox chemistry, allowing for selective oxidation or reduction or organic functional groups or metals via direct electron transfer at an electrode. Such reactions can generate radical, radical cation, or radical anion intermediates or turn over catalysts without using chemical redox reagents, giving rise to reaction conditions that are potentially milder and less environmentally harmful.
Cancer Cell Immortality: Targeting Telomerase and Telomeres (2022)

Overview Finding specific targeted agents for cancer therapy remains a challenge. One of the hallmarks of cancer is the limitless proliferation (immortalization) of cancer cells, which correlates with the activation of the ribonucleoprotein enzyme complex called telomerase. Since 85–90% of primary human cancers express telomerase activity, while most normal cells do not, telomerase is a unique and almost universal therapeutic target for cancer. Although there have been several approaches developed for telomerase targeted therapies, there is still no successful therapeutic agent that has been approved. This article reviews the different approaches to target telomerase and summarizes preclinical and clinical results.
Functional and receptor binding characterization of recombinant murine macrophage inflammatory protein 2: Sequence analysis and mutagenesis identify receptor binding epitopes (1997)

Murine macrophage inflammatory protein-2 (MIP-2), a member of the alpha-chemokine family, is one of several proteins secreted by cells in response to lipopolysaccharide. Many of the alpha-chemokines, such as interleukin-8, gro-alpha/MGSA, and neutrophil activating peptide-2 (NAP-2), are associated with neutrophil activation and chemotaxis. We describe the expression, purification, and characterization of murine MIP-2 from Pichia pastoris. Circular dichroism spectroscopy reveals that MIP-2 exhibits a highly ordered secondary structure consistent with the alpha/beta structures of other chemokines. Recombinant MIP-2 is chemotactic for human and murine neutrophils and up-regulates cell surface expression of Mac-1. MIP-2 binds to human and murine neutrophils with dissociation constants of 6.4 nM and 2.9 nM, respectively. We further characterize the binding of MIP-2 to the human types A and B IL-8 receptors and the murine homologue of the IL-8 receptor. MIP-2 displays low-affinity binding to the type A IL-8 receptor (Kd > 120 nM) and high-affinity binding to the type B IL-8 receptor (Kd 5.7 nM) and the murine receptor (Kd 6.8 nM). The three-dimensional structure of IL-8 and sequence analysis of six chemokines (IL-8, gro-alpha, NAP-2, ENA-78, KC, and MIP-2) that display high-affinity binding to the IL-8 type B receptor are used to identify an extended N-terminal surface that interacts with this receptor. Two mutants of MIP-2 establish that this region is also involved in binding and activating the murine homologue of the IL-8 receptor. Differences in the sequence between IL-8 and related chemokines identify a unique hydrophobic/aromatic region surrounded by charged residues that is likely to impart specificity to IL-8 for binding to the type A receptor.
Control of Hypertension by Ethanol Renal Ablation (1987)

No AccessJournal of Urology1 Jun 1987Control of Hypertension by Ethanol Renal Ablation Ira W. Klimberg, D. Russell Locke, and David M. Drylie Ira W. KlimbergIra W. Klimberg More articles by this author , D. Russell LockeD. Russell Locke More articles by this author , and David M. DrylieDavid M. Drylie More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)75288-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Control of Hypertension by Ethanol Renal Ablation." The Journal of Urology, 137(6), p. 138A © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 137Issue 6June 1987Page: 138A Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Ira W. Klimberg More articles by this author D. Russell Locke More articles by this author David M. Drylie More articles by this author Expand All Advertisement PDF downloadLoading ...
Phonon attenuation and velocity measurements in transparent materials by picosecond acoustic interferometry (1991)

A detailed analysis of the method of picosecond acoustic interferometry to study attenuation and velocity of longitudinal acoustic phonons in transparent materials in the Brillouin frequency range with picosecond laser pulses is presented. Experimental results for fused quartz from 90 to 300 K show good agreement with previous Brillouin scattering data. Measurements on a borosilicate glass (Corning 7059) and sapphire have also been made. This method makes these measurements possible under conditions where conventional approaches are not applicable.
Abstract user interface representations (2003)

This paper examines four XML languages for abstract user interface representation: UIML, XIML, XForms and AIAP. It discusses whether the high level architectures of these languages support the requirements of universal usability by allowing use of personal interfaces. Specific technical requirements include separation of data from presentation, explicit declarative representation of interface elements, their state, dependencies, and semantics, flexibility in inclusion of alternative resources and support for remote control and different interaction styles. Of the languages examined, XForms and AIAP provide the best match to the requirements. While XForms requires an appropriate delivery context to provide full access, the AIAP standard will include specification of the context in which the language is to be used.
<title>High Precision Angle Measurements Off Small Surfaces</title> (1983)

A method is described for measuring the orientation of small plane surfaces several tens of micrometers on a side with a resolution of several seconds of arc. A laser beam waist is located on the test surface which underfills the surface. The reflected beam is detected by a quadrant detector to determine the offset of the beam from its nominal position. This displacement determines the relative angular difference from a predetermined angular standard. Advantages of this method for precise angle determination are the ability to measure small surfaces, insensitivity to translations of the test piece, large test piece clearance for inaccessible surfaces, and compensation for laser drift.
Fluorinated Alcohols as Solvents for Enantioselective Hydrogenation with Chiral Self‐Assembling Rhodium Catalysts (2007)

Abstract We herein describe the beneficial effect of fluorinated alcohols on asymmetric hydrogenation using chiral self‐assembling rhodium complexes. Previously, the application of these catalysts has been hampered by low reaction rates in non‐polar solvents, which are essential for establishing the self‐assembling architecture via hydrogen bonding. Excellent reaction rates are usually observed in alcohols as solvents, but the characteristic hydrogen bonds are cleaved in those media, resulting in poor ee values. We now show for the first time that the disadvantageous properties of both solvent classes on the catalytic reaction can be overcome by using fluorinated alcohols. Due to this key finding, homogeneous catalysis with self‐assembling catalysts is much closer to practical application.
Supplementary Figure 3C from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941 (2023)

Supplementary Figure 3C from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds (2018)

Octahydroindolo[2,3-a]quinolizine ring system forms the basic framework comprised of more than 2000 distinct family members of natural products. Despite the potential applications of this privileged substructure in drug discovery, efficient, atom-economic and modular strategies for its assembly, is underdeveloped. Here we show a one-step build/couple/pair strategy that uniquely allows access to diverse octahydroindolo[2,3-a]quinolizine scaffolds with more than three contiguous chiral centers and broad distribution of molecular shapes via desymmetrization of the oxidative-dearomatization products of phenols. The cascade demonstrates excellent diastereoselectivity, and the enantioselectivity exceeded 99% when amino acids are used as chiral reagents. Furthermore, two diastereoselective reactions for the synthesis of oxocanes and piperazinones, is reported. Phenotypic screening of the octahydroindolo[2,3-a]quinolizine library identifies small molecule probes that selectively suppress mitochondrial membrane potential, ATP contents and elevate the ROS contents in hepatoma cells (Hepa1-6) without altering the immunological activation or reprogramming of T- and B-cells, a promising approach to cancer therapy.