gebhart/patrepeval huggingface dataset:
Development and Characterization of a 2G HTS Roebel Cable for Aircraft Power Systems (2016)

Lightweight megawatt-range power cables in electric aircraft propulsion systems will allow reducing fuel consumption by more than a half. Taking into account the low voltage limitations for onboard use, superconductivity providing high current-carrying capacity becomes an enabling technology for this application. In the frame of a preliminary study of an onboard superconducting power distribution grid, we fabricated and tested a high-temperature superconducting (HTS) Roebel cable. The work was done by a consortium of institutions and supported by Airbus Group Innovations. SuperOx provided a 400 A-class 12-mm-wide 2G HTS wire. The team at the Karlsruhe Institute of Technology prepared 5.5-mm-wide Roebel strands with a transposition length of 226 mm and assembled the strands into a 6-m-long Roebel cable. The team at the Russian Scientific Research and Development Cable Institute performed characterization of the cable. Short samples of the cable were tested to determine their critical currents, mechanical properties, and stability during thermal cycling. For a 4-m-long section of the cable, we measured the critical current, as well as the transport ac losses at frequencies in the range from 50 to 400 Hz. This paper presents the cable design and test results. The feasibility of using 2G HTS Roebel cables in electric aircraft systems is discussed.
028 Impact of Vaginal Prasterone on the Frequency of Urinary Tract Infections (2020)

Vaginal prasterone, an FDA-approved synthetic form of endogenous DHEA, can be converted into active androgens and estrogens. It has been suggested that androgens may decrease the recurrence risk of urinary tract infections (UTIs) in women with genitourinary syndrome of menopause (GSM).
Supplementary Fig. S5 from <i>Salmonella</i>-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumors (2023)

&lt;p&gt;Colony forming unit (CFU) enumeration of ST in tumors of mice treated with and without PEGPH20. Mice with 14-day orthotopic KPC tumors (n=3) were given indicated treatment regimens. Tumors were then extracted at indicated time points post-treatment, homogenized in PBS containing a protease inhibitor mix (Roche), plated on LB-0 plates containing appropriate antibiotics, and then incubated at 37ï‚°C overnight. Data is representative of multiple experiments utilizing identical treatments and post-treatment analyses. (A) CFU comparison of mice treated with ST, with and without PEGPH20, at various time points after treatment. (B) Effects of Gr-1 depletion (Gr1-) on accumulation of shIDO-ST in orthotopic KPC tumors in mice treated with and without PEGPH20. Mice were depleted 24hr prior to treatment. Tumors were extracted 48hr post-treatment and homogenized for CFU enumeration. *p&lt;0.05, **p&lt;0.01, 1-way ANOVA.&lt;/p&gt;
On-chip Microwave-to-Optical Transducer Based on Rare-Earth Ions (2022)

Microwave-to-optical transduction is essential for connecting superconducting platforms with optical quantum networks. We demonstrate coherent transduction in both continuous-wave and pulsed mode using rare-earth ions with an integrated superconducting microwave resonator and nanophotonic optical resonator.
SYSTEM MODEL FOR A LOW DATA RATE FULL DUPLEX OPTICAL COMMUNICATIONS LINK BETWEEN EARTH AND LEO (1999)

International Telemetering Conference Proceedings / October 25-28, 1999 / Riviera Hotel and Convention Center, Las Vegas, Nevada
The construction of lacZ and galK double reporter system and its use in the study of lambda phage N gene regulation (1999)

The construction and use of lacZ and galK double reporter system that facilitates study of N mediated gene regulation is described.Bacterial genetics methods,including Lambda phage and P1 phage techniques were used to construct the strains.The lacZ gene was fused in frame to the first 33 condon of N gene and used as the reporter for N gene expression.Transcription terminators were placed between lacZ and galK ,making galK dependent upon the lambda pL promoter and N antitermination.In presence of N,β galactosidase(β Gal)level was reduced dramatically relative to no N,indicating that N represses its own expression.Repression of N gene expression was at the translational level and occurred at the same time in the same cell and on the same transcript as antitermination was occurring to allow galK expression.
Differential Spring Stiffness Design for Finger Therapy Exercise Device: Bio-inspired from Stiff Pathological Finger Joints (2012)

Frontiers Abstracts Differential Spring Stiffness Design for Finger Therapy Exercise Device: Bio-inspired from Stiff Pathological Finger Joints Chen-Hua Yeow, Chen-Hua Yeow School of Engineering and Applied Sciences, Harvard UniversityDepartment of Bioengineering, National University of Singapore Search for other works by this author on: This Site PubMed Google Scholar Andrew Baisch, Andrew Baisch Search for other works by this author on: This Site PubMed Google Scholar Robert Howe, Robert Howe School of Engineering and Applied Sciences, Harvard University Search for other works by this author on: This Site PubMed Google Scholar Simon Talbot, Simon Talbot Department of Plastic Surgery, Brigham and Women's Hospital Search for other works by this author on: This Site PubMed Google Scholar Conor Walsh Conor Walsh School of Engineering and Applied Sciences, Harvard UniversityWyss Institute for Biologically Inspired Engineering, Harvard University Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information Chen-Hua Yeow School of Engineering and Applied Sciences, Harvard UniversityDepartment of Bioengineering, National University of Singapore Robert Howe School of Engineering and Applied Sciences, Harvard University Simon Talbot Department of Plastic Surgery, Brigham and Women's Hospital Conor Walsh School of Engineering and Applied Sciences, Harvard UniversityWyss Institute for Biologically Inspired Engineering, Harvard University J. Med. Devices. Mar 2012, 6(1): 017538 (1 pages) https://doi.org/10.1115/1.4026716 Published Online: March 12, 2012 Article history Received: May 27, 2011 Revision Received: November 7, 2011
GWAS-GMDR: A program package for genome-wide scan of gene-gene interactions with covariate adjustment based on multifactor dimensionality reduction (2011)

Multifactor dimensionality reduction (MDR) has been successfully applied to identification of gene-gene interactions for the complex traits. Generalized MDR (GMDR) was its extension that allows adjustment for covariates. The current GMDR software mainly focuses on candidate gene association studies with a relatively small number of genetic markers and has some limitations to be extended to genome-wide association studies (GWAS) with a large number of genetic markers. We develop GWAS-GMDR, an effective parallel computing program package with special features for GWAS with a large number of genetic markers by using distributed job scheduling method and/or CUDA-enabled high-performance graphic processing units (GPU). First, GWAS-GMDR implements an effective memory handling algorithm and efficient procedures for GMDR to make joint analysis of multiple genes feasible for GWAS. Second, a weighted version of cross-validation consistency based on `top-K selection' (WCVC <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</sup> ) is proposed to report multiple candidates for causal gene-gene interactions. Third, various performance measures are implemented to evaluate MDR classifiers, including balanced accuracy, tau-b, likelihood ratio and normalized mutual information. Fourth, some popular methods for handling missing genotypes are implemented. Finally, our applications support both CPU-based and GPU-based parallel computing system. We applied our applications using a real genome wide data set from WTCCC Crohn's disease dataset to identify two-way interaction models in genome-wide scale. The GWAS-GMDR package is a powerful tool for the gene-gene interaction analysis in a genome-wide scale. High-performance implementations are provided as native binaries for Linux, Mac OS X and Windows systems.
Surfactant induced nucleation in supersaturated vapors (2000)

The roles of fluoroalcohols in enhancing the binary clusters with water as compared to aliphatic alcohols, and in lowering the barrier to homogeneous nucleation have been investigated. The results suggest that fluorocarbons in the gas phase can be used to lower the surface tension of the condensation nuclei in supersaturated vapors, and therefore enhance the rate of homogeneous nucleation.
Effects of Thermal Cycles on Interfacial Pressure in MV Cable Joints (2019)

The use of medium voltage cable joints is mandatory when dealing with power cable faults and the installation of new lines. However, such an accessory is among the top causes of faults among the grid. To this purpose, one of the quantities monitored to understand the causes of such faults is the interfacial pressure between the insulating layers of the cable joint. In this work, the interfacial pressure between Cross-linked polyethylene (XLPE) and silicon rubber has been evaluated when the cable joint experiences thermal cycles. From the results, the pressure variation caused by the thermal cycles is demonstrated. Such a phenomenon may be connected to the generation of voids and weak spots that accelerate cable joint ageing. Therefore, proper comments and conclusions are drawn.
Microblog Credibility Perceptions: Comparing the United States and China (2013)

Microblogs have become an increasingly important source of information, both in the U.S. (Twitter) and in China (Weibo). However, the brevity of microblog updates, combined with increasing access of microblog content through search rather than through direct network connections, makes it challenging to assess the credibility of news relayed in this manner [34]. This paper reports on experimental and survey data that compare the impact of several features of microblog updates (author’s gender, name style, profile image, location, and degree of network overlap with the reader) on credibility perceptions among U.S. and Chinese audiences. We reveal the complex mechanism of credibility perceptions, identify several key differences in how users from each country critically consume microblog content, and discuss how to incorporate these findings into the design of improved user interfaces for accessing microblogs in different cultural settings.
SNR Estimation in Maximum Likelihood Decoded Spatial Multiplexing (2009)

Link adaptation is a crucial part of many modern communications systems, allowing the system to adapt the transmission and reception strategies to changes in channel conditions. One of the fundamental components of the link adaptation mechanism is signal to noise ratio (SNR) estimation, measuring the instantaneous (mostly post processing) SNR at the receiver. That is, the SNR at the decoder input, which is an important metric for the prediction of decoder performance. In linearly decoded MIMO, which is the common MIMO decoding strategy, the post processing SNR is well defined. However, this is not the case in optimal maximum likelihood (ML) decoding applied to spatial multiplexing (SM). This gap is interesting since ML decoded SM is gaining ever growing interest in recent research and practice due to the rapid increase in computation power, and available near optimal low complexity schemes. In this paper we close the gap and provide SNR estimation schemes for ML decoded SM, which are based on various approximations of the "per stream" error probability. The proposed methods are applicable for both horizonal and vertical decoding. Moreover, we propose a very low complexity implementation for the SNR estimation mechanism employing the ML decoder itself with negligible overhead.
Rapid Scan Mode with THz OSCAT Spectrometer (2012)

We present OSCAT laser systems as a general tool for pump and probe experiments. The current development offers unlimited temporal scanning range using the intracavity motor and a rapid scan mode with a range of 100 ps.
Analysis of the Mobilities of Band 3 Populations Associated with Ankyrin Protein and Junctional Complexes in Intact Murine Erythrocytes (2011)

Current models of the erythrocyte membrane depict three populations of band 3: (i) a population tethered to spectrin via ankyrin, (ii) a fraction attached to the spectrin-actin junctional complex via adducin, and (iii) a freely diffusing population. Because many studies of band 3 diffusion also distinguish three populations of the polypeptide, it has been speculated that the three populations envisioned in membrane models correspond to the three fractions observed in diffusion analyses. To test this hypothesis, we characterized band 3 diffusion by single-particle tracking in wild-type and ankyrin- and adducin-deficient erythrocytes. We report that ∼40% of total band 3 in wild-type murine erythrocytes is attached to ankyrin, whereas ∼33% is immobilized by adducin, and ∼27% is not attached to any cytoskeletal anchor. More detailed analyses reveal that mobilities of individual ankyrin- and adducin-tethered band 3 molecules are heterogeneous, varying by nearly 2 orders of magnitude and that there is considerable overlap in diffusion coefficients for adducin and ankyrin-tethered populations. Taken together, the data suggest that although the ankyrin- and adducin-immobilized band 3 can be monitored separately, significant heterogeneity still exists within each population, suggesting that structural and compositional properties likely vary considerably within each band 3 complex.
Flow Surface Probes for Vector Field Visualization (1994)

We present a technique called flow surface probes for interactive visualization of 3D steady vector fields. The user places in the flow field an arbitrarily-shaped seed surface, which is then deformed over time by the local or global 3D vector field, producing an animation sequence. This sequence and individual frames are used to probe the behavior of the flow field. 1 Introduction In 2D fluid flow visualization, techniques such as stream lines, arrow plots, and the like are commonly used to visualize vector fields with satisfactory results. However, in the 3D case, they usually generate cluttering displays that convey little, if any, useful information. As pointed out by Hesselink, Post, and van Wijk [HPv94], the problem seems to be a fundamental one, as there is no intuitive and psychologically meaningful representation of 3D vectors. Even though we can use arrows to represent single vectors, there is no such simple metaphor for 3D vector fields. Without any obvious visual represe...
The interaction of scientific evidence and politics in debates about preventing malaria in 1925 (2013)

Malaria parasites were identified by Laveran in Algeria in 1883, their cycle largely elucidated by Ross in India in 1895 and transmission of malaria by Anopheles was identified by Grassi in Italy in 1899.1–3 Very soon after the transmission of malaria had been elucidated, the first science-based approaches to preventing the disease were designed and implemented by Celli in Italy.4,5

Italy had had a tradition of draining marshes going back to Etruscan times. In 1883, this strategy was officially implemented by an Italian Royal law and named Bonifica. Because of the role of water in the breeding of Anopheles, Bonifica was not unnaturally assumed to be a way of controlling malaria. Although anti-malaria prophylaxis based on intervening in the biology of Anopheles or on extensive land drainage could be seen as complementary procedures, they were curiously seen to be in opposition. The efficacy of Bonifica as an anti-malaria measure was challenged by experts in malaria prophylaxis and epidemiology. However, in 1925 the Italian government chose to favour Bonifica, and this shaped Italian anti-malaria campaigns for the next 15 years. In selecting Bonifica as the ‘official’ Italian policy of malaria prophylaxis, conflicts within the fascist movement6 played a more significant role than that of science and medicine.
High Data Rate Near-Ultrasonic Communication with Consumer Devices (2021)

Automating device pairing and credential exchange in consumer devices reduce the time users spend with mundane tasks and improve the user experience. Acoustic communication is gaining traction as a practical alternative to Bluetooth or Wi-Fi because it can enable quick and localized information transfer between consumer devices with built-in hardware. However, achieving high data rates (&gt;1 kbps) in such systems has been a challenge because the systems and methods chosen for communication were not tailored to the application. In this work, a high data rate, near-ultrasonic communication (NUSC) system is proposed to transfer personal identification numbers (PINs) to establish a connection between consumer laptops using built-in microphones and speakers. The similarities between indoor near-ultrasonic and underwater acoustic communication (UWAC) channels are identified, and appropriate UWAC techniques are tailored to the NUSC system. The proposed system uses the near-ultrasonic band at 18-20 kHz, and employs coherent modulation and phase-coherent adaptive equalization. The capability of the proposed system is explored in simulated and field experiments that span different device orientations and distances. The experiments demonstrate data rates of 4 kbps over distances of up to 5 meters, which is an order of magnitude higher than the data rates reported with similar systems in the literature.
Real-Time Monitoring of the Atrazine Degradation by Liquid Chromatography and High-Resolution Mass Spectrometry: Effect of Fenton Process and Ultrasound Treatment (2022)

High resolution mass spectrometry (HRMS) was coupled with ultra-high-performance liquid chromatography (uHPLC) to monitor atrazine (ATZ) degradation process of Fenton/ultrasound (US) treatment in real time. Samples were automatically taken through a peristaltic pump, and then analysed by HPLC-HRMS. The injection in the mass spectrometer was performed every 4 min for 2 h. ATZ and its degradation metabolites were sampled and identified. Online Fenton experiments in different equivalents of Fenton reagents, online US experiments with/without <i>Fe</i><sup>2+</sup> and offline Fenton experiments were conducted. Higher equivalents of Fenton reagents promoted the degradation rate of ATZ and the generation of the late-products such as Ammeline (AM). Besides, adding <i>Fe</i><sup>2+</sup> accelerated ATZ degradation in US treatment. In offline Fenton, the degradation rate of ATZ was higher than that of online Fenton, suggesting the offline samples were still reacting in the vial. The online analysis precisely controls the effect of reagents over time through automatic sampling and rapid detection, which greatly improves the measurement accuracy. The experimental set up proposed here both prevents the degradation of potentially unstable metabolites and provides a good way to track each metabolite.
ChemInform Abstract: SYNTHESIS OF PARAGLOBOSIDE ANALOGS (1978)

Abstract Es wird die Herstellung von Analogen des Paraglobosids (I), einer als Oberflächen‐Antigen bekannten Verbindung aus Erythrocyten, beschrieben.
Magnetization transfer in liposome and proteoliposome samples that mimic the protein and lipid composition of myelin (2019)

Although magnetization transfer (MT) has been widely used in brain MRI, for example in brain inflammation and multiple sclerosis, the detailed molecular origin of MT effects and the role that proteins play in MT remain unclear. In this work, a proteoliposome model system was used to mimic the myelin environment and to examine the roles of protein, cholesterol, brain cerebrosides, and sphingomyelin embedded in the liposome matrix. Exchange parameters were determined using a double-quantum filter experiment. The goal was to determine the relative contributions to exchange and MT of cerebrosides, sphingomyelin, cholesterol, and proteins in 1,2-dimyristoyl-sn-glycero-3-phosphocholine bilayers. The main finding was that cerebrosides produced the strongest exchange effects, and that these were even more pronounced than those found for proteins. Sphingomyelin (which also has exchangeable groups at the head of the fatty acid chains, albeit closer to the lipid acyl chains) and cholesterol showed only minimal transfer. Overall, the extracted exchange rates appeared much smaller than commonly assumed for -OH and -NH groups.
VPE Growth Of InGaAs For Large Area And Extended Spectral Range Photodetectors (1987)

The hydride vapor phase epitaxy (VPE) technique has been used to grow In(x) Ga(1-x) As on InP substrates with 0&lt;x&lt;0.8. The &quot;double barrel&quot; VPE reactor along with relevant growth parameters will be discussed. The effects of temperature, flow rates and reactor geometry on compositional and thickness uniformity of grown layers will be described. An automatic probing station has been used to evaluate devices (i.e. p-i-n photodetectors) across the whole wafer. Device characteristics will be correlated with the compositional and thickness variations of grown layers on that wafer. Finally, detectors manufactured from the above wafers will be discussed, i.e.: (a) detectors with extended spectral response from 0.8 microns to 2.55 microns, as opposed to standard In(0.53) Ga(0.44) As detectors which respond in the range of 1.0 - 1.7 microns; (b) operational characteristics of large area In(0.53) Ga(0.44) As detectors with diameters of 1.0, 2.0 and 3.0mm respectively, will be presented and discussed.
Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors (2019)

Activating mutations in <i>PIK3CA</i> are frequent in human breast cancer, and phosphoinositide 3-kinase alpha (PI3Kα) inhibitors have been approved for therapy. To characterize determinants of sensitivity to these agents, we analyzed <i>PIK3CA</i>-mutant cancer genomes and observed the presence of multiple <i>PIK3CA</i> mutations in 12 to 15% of breast cancers and other tumor types, most of which (95%) are double mutations. Double <i>PIK3CA</i> mutations are in cis on the same allele and result in increased PI3K activity, enhanced downstream signaling, increased cell proliferation, and tumor growth. The biochemical mechanisms of dual mutations include increased disruption of p110α binding to the inhibitory subunit p85α, which relieves its catalytic inhibition, and increased p110α membrane lipid binding. Double <i>PIK3CA</i> mutations predict increased sensitivity to PI3Kα inhibitors compared with single-hotspot mutations.
The EuroBioBank Network: 10 years of hands-on experience of collaborative, transnational biobanking for rare diseases (2014)

The EuroBioBank (EBB) network (www.eurobiobank.org) is the first operating network of biobanks in Europe to provide human DNA, cell and tissue samples as a service to the scientific community conducting research on rare diseases (RDs). The EBB was established in 2001 to facilitate access to RD biospecimens and associated data; it obtained funding from the European Commission in 2002 (5th framework programme) and started operation in 2003. The set-up phase, during the EC funding period 2003-2006, established the basis for running the network; the following consolidation phase has seen the growth of the network through the joining of new partners, better network cohesion, improved coordination of activities, and the development of a quality-control system. During this phase the network participated in the EC-funded TREAT-NMD programme and was involved in planning of the European Biobanking and Biomolecular Resources Research Infrastructure. Recently, EBB became a partner of RD-Connect, an FP7 EU programme aimed at linking RD biobanks, registries, and bioinformatics data. Within RD-Connect, EBB contributes expertise, promotes high professional standards, and best practices in RD biobanking, is implementing integration with RD patient registries and 'omics' data, thus challenging the fragmentation of international cooperation on the field.