gebhart/patrepeval huggingface dataset:
Glycomic analysis by capillary electrophoresis–mass spectrometry (2008)

Abstract The occurrence of multiple glycosylation sites on a protein, together with the number of glycan structures which could potentially be associated with each site (microheterogeneity) often leads to a large number of structural combinations. These structural variations increase with the molecular size of a protein, thus contributing to the complexity of glycosylation patterns. Resolving such fine structural differences has been instrumentally difficult. The degree of glycoprotein microheterogeneity has been analytically challenging in the identification of unique glycan structures that can be crucial to a distinct biological function. Despite the wealth of information provided by the most powerful mass spectrometric (MS) and tandem MS techniques, they are not able to readily identify isomeric structures. Although various separation methods provide alternatives for the analysis of glycan pools containing isomeric structures, capillary electrophoresis (CE) is often the method of choice for resolving closely related glycan structures because of its unmatched separation efficiency. It is thus natural to consider combining CE with the MS‐based technologies. This review describes the utility of different CE approaches in the structural characterization of glycoproteins, and discusses the feasibility of their interface to mass spectrometry. © 2009 Wiley Periodicals, Inc., Mass Spec Rev 28:207–222, 2009
Smoothly Tunable Surface Properties of Aluminum Oxide Core–Shell Nanoparticles By A Mixed-Ligand Approach (2014)

We present a facile solution-based procedure for tailoring the surface properties of aluminum oxide nanoparticles (AlOx-NPs) by the formation of tunable core-shell systems with self-assembled monolayers. By employing chained molecules with a phosphonic acid anchor group and either hydrophobic or hydrophilic chains the surface properties of the nanoparticles change dramatically. So, the solubility can be tuned orthogonal from trifluorotoluene (CF3-C6H5) for hydrophobic shell to water (H2O) for hydrophilic functionalization respectively. Spray coated films of those functionalized nanoparticles exhibited superhydrophobic or superhydrophilic properties. The surface properties can be tuned smoothly by the formation of a mixed ligand monolayer from corresponding stoichiometric mixtures of the ligands. The core-shell nanoparticles were investigated by means of thermogravimetric analysis, TGA; Fourier transform infrared spectroscopy, FTIR; and static contact angle goniometry, SCA. The effect of different dipole moments of the SAM molecules in mixed shell nanoparticles to their stability in dispersions was studied by zeta potential measurements.
Coarse and Fine Continuously Tunable Optical Delay Using the Time-of-flight in Fiber Bragg Gratings and Wavelength Conversion (2018)

We use the time-of-flight in arrayed, channelized and chirped fiber Bragg gratings along with wavelength conversion in PPLN waveguides to build continuously coarse- and fine-tunable delay line. More than 20 ns continues tuning range is achieved with less-than-0.6dB OSNR penalty for a 10 Gbaud QPSK signal.
Supplementary Video 1 from Axon Guidance Factor SLIT2 Inhibits Neural Invasion and Metastasis in Pancreatic Cancer (2023)

&lt;p&gt;AVI file - 2196KB, Recording of unidirectional migration of MiaPaCa cells along a contacted neurite from a DRG-tumor cell co-culture assay (Example 1).&lt;/p&gt;
Self-Aligned Top-Gate Oxide Thin-Film Transistor Formed by Aluminum Reaction Method (2011)

We developed a novel highly reliable self-aligned top-gate oxide semiconductor thin-film transistor (TFT) formed by the aluminum (Al) reaction method. In this method, Al diffusion into the oxide semiconductor was observed. The low sheet resistivity of the source/drain regions was attributed to Al working as a donor in the oxide semiconductor. The TFTs with 4 µm channel length exhibited a field-effect mobility of 9.8 cm2 V-1 s-1, a threshold voltage of -1.5 V, and a subthreshold swing of 0.22 V/decade. Highly reliable TFTs were obtained after 300 °C annealing without increasing the sheet resistivity of source/drain regions.
Electrostatic dispersion of aerosol particles carrying unipolar charge. (1985)

The electrostatic dispersion of polydisperse aerosol particles carrying unipolar charge was studied theoretically and experimentally. The time-dependent behavior of polydisperse aerosols due to electrostatic dispersion in stationary air and a laminar pipe flow is evaluated by numerically integrating the "birth-death" equations for various conditions. The results are compared with those obtained from the well-known Wilson''s equation, which is derived for a monodisperse aerosol having uniform charge quantity in stationary air. The effects of particle size distribution, particle charge distribution, image force and flow conditions of aerosols on the aerosol behavior were studied. It was found that Wilson''s equation can roughly estimate the decrease in number concentration of polydisperse aerosols, if mean electrical mobility and geometric mean radius are used to take account of the effect of polydispersity of both charge and size. Some of the calculated results were in good agreement with the experimental results obtained in a closed chamber and in a laminar pipe flow.
α-TEA as a stimulator of tumor autophagy and enhancer of antigen cross-presentation (2012)

Stimulation of apoptosis has been reported as the primary mechanism of tumor cell death induced by alpha-tocopheryloxyacetic acid (α-TEA), an esterase-resistant, semi-synthetic derivative of vitamin E (R-R-R-α-tocopherol). New information now shows that α-TEA also triggers tumor cell autophagy and promotes antigen cross-presentation. Autophagosome-enriched fractions of α-TEA-treated tumor cells (α-TAGS) efficiently cross-primed antigen-specific CD8 (+) T cells and vaccination with dendritic cells (DC) pulsed with α-TAGS reduced lung metastases and increased survival of tumor-bearing mice. Taken together, these observations suggest that both autophagy and apoptosis signaling programs are activated in tumor cells by α-TEA treatment and may contribute to tumor cell death. We propose that autophagy-dependent enhancement of cross-presentation is a novel mechanism of α-TEA-mediated tumor immunity and that α-TEA can be exploited as an adjuvant to enhance the antitumor response.
THE EFFECT OF EXPANSIVE ADDITIVE ON PHYSICAL PROPERTIES IN EARLIER AGE OF CONCRETE WITH PORTLAND BLAST FURNACE SLAG CEMENT CLASS C (2017)

高炉セメントC種を用いたコンクリートに膨張材を混和させ、初期材齢に与える影響について検討した。コンクリートの基礎物性に関して、凝結試験、圧縮強度試験、膨張率測定試験を実施した。高炉セメントC種コンクリートは膨張材混和により凝結は遅延するが、初期材齢における硬化体への強度増進効果があることを確認できた。一方で脱型までの封緘養生期間が長いため、拘束棒を用いた膨張測定試験（B法）では膨張材の水中養生期間が短くなり標準添加量における膨張性能を十分に発揮しなかったが、軽量型枠を用いた拘束膨張試験法では通常の膨張性能を確認できた。
Spectroscopy of C{sub 60} derivatives and their polymer composites (1995)

Electronic spectroscopy as a function of doping (gas-solid reaction with alkali metal atoms) of C{sub 61} fulleroid and methanofullerene isomers as well as C{sub 62} derivatives will be reported. The properties of composites with a dialkoxy poly(para-phenyle nevinylene) with special emphasis on the photoinduced electron transfer from the polymer to C{sub 61} isomers will be reported. The fabrication of devices such as photodiodes and their characteristics will also be included.
P‐72: Efficient Red, Green, and Blue QD‐LEDs Fabricated with the QD Transplanting Process on a Common Hole Transport Layer (2012)

Abstract We demonstrate efficient red, green, and blue (RGB) quantum dot (QD)‐based light‐emitting diodes (QD‐LEDs) by using QD transplanting method on a common, vacuum‐deposited, hole transport layer. We can pattern RGB QD‐LEDs with a micrometer scale for full‐color QD‐LED displays. We can also demonstrate practicable quantum dot light‐emitting devices with RGB patterned pixels on unit devices as well as white light‐emitting devices for everyday applications.
Iodine-Catalyzed Highly Effective Pictet–Spengler Condensation: An Efficient Synthesis of Tetrahydro-β-carbolines (2008)

Abstract Molecular iodine was found to be an efficient catalyst for the two-component Pictet–Spengler condensation of tryptamine with aldehydes, which leads to the formation of tetrahydro-β-carbolines in high yields.
Quantum noise of dark pulse microcombs (2022)

We investigate the fundamental timing jitter of dark pulse microcombs generated in an AlGaAs microresonator, where the quantum-limited frequency noise of the 91-GHz repetition rate is measured to be 0.5 Hz 2 /Hz.
THE 18 kDa SIGMA‐2 Receptor and PGRMC1 are Derived From Separate Genes (2015)

The sigma‐2 receptor (S2R) is a unique binding site expressed in many mammalian tissues. Due to high expression in tumors, the S2R is a promising target for cancer diagnostic imaging. However, the sequence of the S2R has remained a matter of debate. Historically the identity of S2R has been determined by these criteria: (1) the S2R binds with high affinity to 1,3‐di‐o‐tolylguanidine (DTG) and haloperidol but not the selective sigma‐1 receptor ligand, (+)‐pentazocine; (2) specific photolabeling with [ 3 H]Azido‐DTG, and [ 125 I]‐iodoazido‐fenpropimorph ([ 125 I]IAF) has shown the apparent molecular size of S2R to be 18‐21kDa. The progesterone receptor membrane component 1 (PGRMC1), a 25 kDa protein, has been recently reported to be the S2R. To establish the identity of the S2R, we created a PGRMC1 knockout NSC34 cell line using CRISPR/Cas9 technology. We found that in NSC34 cells devoid of PGRMC1, the maximum binding (Bmax) of haloperidol protectable [ 3 H]‐DTG binding was similar to that of wild‐type control cells. Moreover, in both control and PGRMC1‐KO cells, [ 125 I]IAF selectively photolabeled a DTG protectable S2R‐18kDa protein. A series of previously reported highly selective S2R compounds showed protection of [ 125 I]‐IAF photolabeling of the S2R‐18kDa in PC12 cell membranes that contain both PGRMC1 and S2R‐18kDa. These results support the conclusion that PGRMC1 and S2R‐18kDa are separate proteins derived from two different genes. Cloning and characterization of the S2R‐18kDa will provide further clarification.
Identifying significant associations using free text problem summary lists in a clinical data repository. (2007)

Recent studies have been seeking common signatures in gene expression profiles in order to find novel associations. We chose to test the extensibility of a tool created to perform association analyses of gene expression signatures by applying the same technique to problem summary lists. Both commonly known as well as less known associations were found using this technique.
Laser Beam Propagation in Deep Turbulence: Formation and Dynamics of Giant Irradiance Spikes (2015)

We report an observation of irregular giant intensity spikes in numerical wave-optics simulation of laser beam propagation in deep (volume) turbulence. The giant spikes’ physics-based origin, probability of appearance, and impact on intensity scintillation index are discussed.
ChemInform Abstract: A Modular Enantioselective Approach to Construction of the Macrolactone Core of Polycavernoside A. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Structured Design Based on the Inversion Factor Parameter: Case Study of ¿¿ Modulator System (2007)

This paper presents the design flow from system-level specifications to transistor-level design for three different fully-differential amplifiers composing the first and the second integrator of a second-order hybrid multi-bit ΔΣ modulator. The circuit-level specifications for each amplifier are extracted using behavioral models and time-domain system-level simulations with a SNDR target value of 93 dB ± 2 dB. The amplifiers are designed using the structured analog design methodology consisting of circuit partitioning into basic analog blocks, specification derivation for each basic block, and transistor sizing in a specific design sequence. Transistor-level design is based on the choice of the inversion factor and the transistor length to achieve the required specifications of each block. After all three analog amplifiers are sized, the system-level performance is confirmed by time-domain simulations, and the obtained SNDR value is within the specified range.
Gas tube-switched high voltage DC power converter (2023)

A direct current (DC)-DC converter includes a transformer and a gas tube-switched inverter circuit. The transformer includes a primary winding and a secondary winding. The gas tube-switched inverter circuit includes first and second inverter load terminals and first and second inverter input terminals. The first and second inverter load terminals are coupled to the primary winding. The first and second inverter input terminals are couplable to a DC node. The gas tube-switched inverter circuit further includes a plurality of gas tube switches respectively coupled between the first and second inverter load terminals and the first and second inverter input terminals. The plurality of gas tube switches is configured to operate to generate an alternating current (AC) voltage at the primary winding.
Integrated photonics for NASA applications (2019)

NASA is working with US industry and academia to develop Photonic Integrated Circuits (PICs) for: (1) Sensors (2) Analog RF applications (3) Computing and free space communications. The PICs provide reduced size, weight, and power that is critical for space-based systems. We describe recent breakthrough 3D monolithic integration of photonic structures, particularly high-speed graphene-silicon devices on CMOS electronics to create CMOS-compatible highbandwidth transceivers for ultra-low power Terabit-scale optical communications. An integrated graphene electro-optic modulator has been demonstrated with a bandwidth of 30 GHz. Graphene microring modulators are especially attractive for dense wavelength division multiplexed (DWDM) systems. For space-based optical communication and ranging we have demonstrated generating a variable number of channels from a single laser using breadboard components, using a single-sideband carrier-suppressed (SSBCS) modulator driven by an externally-supplied RF tone (arbitrary RF frequency), a tunable optical bandpass filter, and an optical amplifier which are placed in a loop. We developed a Return--to-Zero (RZ) Differential Phase Shift Keying (DPSK) laser transmitter PIC using an InP technology platform that includes a tunable laser, a Semiconductor Optical Amplifier (SOA), high-speed Mach-Zehnder Modulator (MZM), and an electroabsorption (EAM) modulator. A Silicon Nitride (SiN) platform integrated photonic circuit suitable for a spectrally pure chip-scale tunable opto-electronic RF oscillator (OEO) that can operate as a flywheel in high precision optical clock modules, as well as radio astronomy, spectroscopy, and local oscillator in radar and communications systems is needed. We have demonstrated a low noise optical frequency combs generation from a small OEO prototypes containing very low loss (~1 dB) waveguide couplers of various shapes and sizes integrated with an ultrahigh-Q MgF2 resonators. An innovative miniaturized lab-on-a-chip device is being developed to directly monitor astronaut health during missions using ~3 drops of body fluid sample like blood, urine, and potentially other body fluids like saliva, sweat or tears. The first-generation system comprises a miniaturized biosensor based on PICs (including Vertical Cavity Surface Emitting Laser – VCSEL, photodetector and optical filters and biochemical assay that generates a fluorescent optical signal change in response to the target analyte.
Supplementary Document 2 from Development and Validation of a Gene Profile Predicting Benefit of Postmastectomy Radiotherapy in Patients with High-Risk Breast Cancer: A Study of Gene Expression in the DBCG82bc Cohort (2023)

&lt;p&gt;Transfer of DBCG-RT profile to RT-qPCR on formalin-fixed, paraffin-embedded material.&lt;/p&gt;
Towards well-defined node-based topologies of functionally directional neuronal circuits on multielectrode arrays (2018)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Non-linearity in chalcogenide glasses and fibers, and their applications (2008)

High nonlinearity and large IR transparency make chalcogenide fibers well suited for compact Raman amplifiers, supercontinuum generation and other mid-IR sources. As2S3 fiber has record high theoretical gain compared with silica fiber for slow-light applications.
Construction, Rescue, and Characterization of Vectors Derived from Ovine Atadenovirus (2003)

Gene transfer vectors derived from ovine atadenovirus type 7 (OAdV) can efficiently infect a variety of mammalian cells in vitro and in vivo to deliver and express transgenes. However, early OAdV vectors were designed on human mastadenovirus principles prior to the complete characterization of OAdV genes and transcripts. The distinctive arrangement of the OAdV genome has suggested ways to improve OAdV vector design and utility. We therefore developed a cosmid-based approach that allows efficient construction of recombinant ovine atadenovirus genomes in which the transgene is inserted at one of three sites. Viruses were rescued by transfection of viral DNA into a new ovine fetal skin fibroblast producer cell line, HVO156. The suitability of the three insertion sites was compared with respect to virus rescue efficiency, gene expression levels, and genetic stability of the vectors. We found that one vector with a transgene inserted at site 1, between the pVIII and fiber genes, was unstable. Only one vector that carried a transgene at site 2, near the right end of the genome, together with a nearby deletion was rescued. In contrast, several vectors with different transgenes inserted in site 3, between the E4 and RH transcription units, were repeatedly rescued, and these vectors were stable over at least four passages. Transgene orientation in site 3 had only little effect on expression. Finally, a vector carrying a human factor IX cDNA at site 3, when administered intravenously, produced nearly physiological levels of human factor IX in mice. The availability of an efficient method for vector construction and the identification of a new insertion site for virus rescue and gene expression substantially enhance the utility of the OAdV vector system.
Configurationally Restricted Bismacrocyclic CXCR4 Receptor Antagonists (2006)

A zinc(II) containing configurationally restricted analogue of bismacrocyclic cyclam-type CXCR4 chemokine receptor antagonists has been synthesized and shown to adopt only one configuration in solution. The single crystal X-ray structure reveals favorable binding to acetate via a bidentate chelation that can be related to the proposed interaction with aspartate on the receptor protein surface. The zinc(II) complex is highly active against HIV infection in vitro.
Low-Wavenumber Wall Pressure Measurements in Zero-Pressure Gradient Boundary Layer Flow (2022)

View Video Presentation: https://doi.org/10.2514/6.2022-1795.vid Low-wavenumber pressure fluctuations generated by turbulent boundary layers are the source of both flow-generated sound and structural vibration in many applications. However, the form and origin of these fluctuations are poorly understood, not least because measurement of this component of the wall pressure spectrum is especially challenging. This paper describes a new method for low-wavenumber pressure measurement using arrays of resonating sensors inspired by acoustic metamaterials. Measurements are made using the array in high Reynolds number turbulent boundary layers and shows the sub-convective components of the wall pressure spectrum in a zero-pressure gradient turbulent boundary layer flow.
Corrections to: “The Soft Compiler: A Web-Based Tool for the Design of Modular Pneumatic Circuits for Soft Robots” (2022)

In Section “I. Introduction” on page 6060 of our original article [1], we describe Rothemund et al.’s work on the soft bistable valve [2]. The corresponding reference to their work was cited incorrectly.
Synthesis of Diverse Asparagine Linked Oligosaccharides (2005)

Oligosaccharides are linked to the protein surface and play roles in a number of biological events. Therefore, much attention is being paid to research to investigate the function of the oligosaccharides. In order to investigate the function of oligosaccharides, many synthetic approaches have been examined by synthesizing N-linked oligosaccharides. In this paper, we introduce recent synthetic developments focusing on the synthesis of N-linked oligosaccharides.
Controllable cell adhesion, growth and orientation on layered silk protein films (2013)

Due to their mechanical stability, biocompatibility and biodegradability, silks are promising materials for various biomedical applications including tissue engineering. Since the shape and the organisation of cells in and on scaffolds both affect their function, we tested patterned silk scaffolds made of three different silk proteins concerning their influence on cell adhesion, growth and orientation. Two different cell lines, BALB/3T3 fibroblasts and C2C12 myoblasts, showed controllable cell adhesion as well as orientation dependent on the silk proteins used and patterns made. Surprisingly, the presence of the integrin binding motif RGD did not influence cell adhesion and orientation on structured silk films, although it did so significantly on flat films.
Line-edge roughness (LER) optimization on 300-mm DUV alternating phase shift (altPSM) processes (2003)

As critical dimensions (CDs) shrink to 130 nm node and below, LER consumes a substantial amount of CD budget and consequently affects the electrical performance of the circuitry adversely. While phase shift processes and trim etch have been broadly implemented into integration processes, to understand the impact of photo and etch processing parameters on LER and furthermore to control LER becomes crucial. In this paper, the line edge roughness (LER) on DUV 300 mm alternating phase shift processing was characterized as a function of illumination conditions and resist processing parameters. The imaging imbalancing was discussed and demonstrated with rigorous mask topography simulation and the effect of phase shifter on the LER was reported. The CD and LER common process window of iso, dense, and semi-isolated line/space as well as the effect of diluted developer concentration on LER were investigated in order to obtain the robust processes with the lowest LER at reasonable throughput. A molecular dynamic simulator of LER generated by using the concept of Monte Carlo simulation was demonstrated and will be used for further simulation down to 65 nm nodes. Finally, the etch transfer of LER in a BEOL short loop film stack of JSR LKD5109 porous low-k and silicon oxy-carbide was reported and the root cause of LER during etch was investigated by partitioning the etch steps.
Power voltage-current converter using quasi-complementary MOSFET current mirrors (2011)

A voltage current convertor is described having a quasi complementary class AB architecture that is particularly suited to implementation using discrete power MOSFETs. High-voltage mirror designs are presented, enabling the construction of sources with kilovolt compliance range, tens of watts of output power and greater than 100 kHz bandwidth. GΩ output impedance and distortion below 1% can be obtained with no trimming or transistor matching.