gebhart/patrepeval huggingface dataset:
A comparative benchmark of classic DNA motif discovery tools on synthetic data (2021)

Hundreds of human proteins were found to establish transient interactions with rather degenerated consensus DNA sequences or motifs. Identifying these motifs and the genomic sites where interactions occur represent one of the most challenging research goals in modern molecular biology and bioinformatics. The last twenty years witnessed an explosion of computational tools designed to perform this task, whose performance has been last compared fifteen years ago. Here, we survey sixteen of them, benchmark their ability to identify known motifs nested in twenty-nine simulated sequence datasets, and finally report their strengths, weaknesses, and complementarity.
DICTIONARY OF THE ECONOMIC PRODUCTS OF INDIA pages 535 to 560 (2014)

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Effectiveness of a whole cell pertussis vaccine in child-care centers and schools (1996)

The increase in pertussis in Quebec is not caused by a low vaccine coverage. A low vaccine effectiveness may contribute to the resurgence of pertussis in the past decade.
Optical pulse compression using cascaded quadratic nonlinearities in periodically poled lithium niobate (2004)

Efficient pulse compression was achieved by the use of cascaded quadratic nonlinearities in 10-mm-long periodically poled MgO-doped lithium niobate. An off-diagonal component of the nonlinear coefficient was utilized for group-velocity matched cascaded interactions at the fundamental wavelength of 1560 nm. Simultaneously compressed fundamental and second-harmonic pulses of ∼35 fs duration were obtained from the 110-fs-pump pulses.
22% Higher performance, 2x SCM write endurance heterogeneous storage with dual storage class memory and NAND flash (2017)

Storage class memories (SCMs); for instance, (STT-)MRAM, ReRAM, PRAM, and 3D XPoint, have much attention from storage systems. Each SCM has different characteristics, such as read/write latency, endurance, and bit cost. For example, MRAM has short latency and high endurance, but its cost is high. In contrast, ReRAM, PRAM, and 3D XPoint have lower endurance, but their cost is lower than MRAM. From these SCM characteristics, MRAM is classified into memory-type SCM (M-SCM), and ReRAM, PRAM, and 3D XPoint are called storage-type SCM (S-SCM). Previous studies show that SCM improves NAND flash based storage performance. However, cost of M-SCM is too high for storage usage. To bring out the best of M-SCM and S-SCM characteristics, this paper proposes a heterogeneous storage with two types of SCM, called dual SCM, and NAND flash memory. In the proposed storage, M-SCM stores very frequently accessed super-hot data and S-SCM stores hot data. By considering the storage performance and total storage cost, only 1% of M-SCM improves the storage performance by 22% and write endurance of S-SCM by 2 times compared with conventional S-SCM and NAND flash hybrid storage. With this storage configuration, M-SCM and S-SCM should have write cycles 3.2×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and 4.5×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> times higher than MLC NAND flash.
Acute antihypertensive response to tempol in the SHR depends on ATP‐sensitive potassium channel (K ATP ), but not large‐conductance Ca2+‐activated potassium (BK) channels (2007)

Acute intravenous (IV) administrations of the piperidine nitroxides reduce BP and heart rate (HR) in SHR in proportion to their superoxide dismutase (SOD) mimetic activity. Blockade of nitric oxide synthase (NOS) blunted 40% of the fall in MAP with IV tempol whereas blockade of ganglionic sympathetic neurotransmission with hexamethonium blunted 40% of the fall in MAP, and combined blockade blunted about 80% of the fall in BP. Central administration of tempol was ineffective. Here, we tested the hypothesis that the tempol activates potassium conductances in vivo. Tempol caused dose-dependent reductions in MAP and HR maximal at 174 μmol/kg (ΔMAP −56 ± 4 mmHg and ΔHR −34 ± 5 min−1, n=7). Activation of KATP channel with cromakalim (50 μg iv bolus and 50 μg /hr, iv), with coinfusion of norepinephrine to restore BP toward control level significantly reduced tempol antihypertensive response by 40% (at 174 μmol/kg, ΔMAP −33 ± 5 mmHg, p < 0.01), whereas blockade of KATP channels with glibenclamide (15 mg/kg) significantly reduced tempol antihypertensive response by 31% (ΔMAP −46 ± 10 vs. control −67 ± 8 mmHg, n=6; p<0.01). In contrast, inhibition of BK channels with iberiotoxin (100 and 300 μg/kg, n=6) did not affect tempol’s antihypertensive effect. In conclusion, the acute antihypertensive response to IV tempol is mediated via potentiation of NO, reduction in sympathetic tone and activation of KATP, but not BK channels.
Priming with a Potent HIV-1 DNA Vaccine Frames the Quality of Immune Responses prior to a Poxvirus and Protein Boost (2018)

The use of heterologous immunization regimens and improved vector systems has led to increases in immunogenicity of HIV-1 vaccine candidates in nonhuman primates. In order to resolve interrelations between different delivery modalities, three different poxvirus boost regimens were compared. Three groups of rhesus macaques were each primed with the same DNA vaccine encoding Gag, Pol, Nef, and gp140. The groups were then boosted with either the vaccinia virus strain NYVAC or a variant with improved replication competence in human cells, termed NYVAC-KC. The latter was administered either by scarification or intramuscularly. Finally, macaques were boosted with adjuvanted gp120 protein to enhance humoral responses. The regimen elicited very potent CD4<sup>+</sup> and CD8<sup>+</sup> T cell responses in a well-balanced manner, peaking 2 weeks after the boost. T cells were broadly reactive and polyfunctional. All animals exhibited antigen-specific humoral responses already after the poxvirus boost, which further increased following protein administration. Polyclonal reactivity of IgG antibodies was highest against HIV-1 clade C Env proteins, with considerable cross-reactivity to other clades. Substantial effector functional activities (antibody-dependent cell-mediated cytotoxicity and antibody-dependent cell-mediated virus inhibition) were observed in serum obtained after the last protein boost. Notably, major differences between the groups were absent, indicating that the potent priming induced by the DNA vaccine initially framed the immune responses in such a way that the subsequent boosts with NYVAC and protein led only to an increase in the response magnitudes without skewing the quality. This study highlights the importance of selecting the best combination of vector systems in heterologous prime-boost vaccination regimens.<b>IMPORTANCE</b> The evaluation of HIV vaccine efficacy trials indicates that protection would most likely correlate with a polyfunctional immune response involving several effector functions from all arms of the immune system. Heterologous prime-boost regimens have been shown to elicit vigorous T cell and antibody responses in nonhuman primates that, however, qualitatively and quantitatively differ depending on the respective vector systems used. The present study evaluated a DNA prime and poxvirus and protein boost regimen and compared how two poxvirus vectors with various degrees of replication capacity and two different delivery modalities-conventional intramuscular delivery and percutaneous delivery by scarification-impact several immune effectors. It was found that despite the different poxvirus boosts, the overall immune responses in the three groups were similar, suggesting the potent DNA priming as the major determining factor of immune responses. These findings emphasize the importance of selecting optimal priming agents in heterologous prime-boost vaccination settings.
ChemInform Abstract: Diastereoselective Oxidation of Sulfides to Sulfoxides. Synthesis of Novel C‐6 Sulfoxy Tetrahydromevinic Acids. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Novel Liquid Phase Sintered Sn-In Solders with Tailorable Properties for Thermal Interface Material and Interconnect Applications (2007)

At present, there is significant interest in low-temperature, indium-based materials for both thermal interface material (TIM) applications as well as interconnect applications for packaging thermally sensitive next-generation devices. The attractive properties of these solders include: (i) high shear compliance under low strain rate conditions, and (ii) high electrical/thermal conductivity, both of which are critical for TIMs and interconnects. However, currently used indium-based solders suffer from 2 serious shortcomings: (i) high cost due to high indium content, and (ii) very low compressive strength and creep resistance which may lead to structural instability following heat-sink attachment. In order to circumvent these problems, and also introduce a built-in melting point hierarchy following initial reflow, a radically different approach for producing microelectronic solder joints based on liquid phase sintering (LPS) is being developed. In this paper, we report on the processing and characterization of LPS Sn-In solders, the microstructure of which consists predominantly of particles of the high melting Sn and a smaller amount of particles of low melting In. By optimizing the In content, highly compliant LPS solders with flow stresses close to that of pure In were obtained. The electrical and thermal conductivity of the LPS solder was found to be about half that of pure In. Following LPS, the melting point of the solder was found to have increased by 30-40degC, thereby enabling this material to be resistant to melting during subsequent high temperature packaging steps. Finally, it is demonstrated that metallurgically good joints can be produced between this new solder and Cu substrates during a single step which combined LPS with joining.
Loss of Ice-Nucleating Activity and Avoidance of Inoculative Freezing with Puparium Formation Induced by 20-Hydroxyecdysone in Eurosta solidaginis(Diptera:Tephritidae) (1993)

Overwintering larvae of the goldenrod gall fly Eurosta solidaginis begin to freeze at temperatures above -10°C. The initiation of freezing at relatively high subzero temperatures may involve multiple ice nucleation mechanisms to protect the insect from lethal intracellular freezing. In spring, the insect changes the mode of its cold-hariness from freeze-tolerant to freeze-susceptible type, with the metamorphosis from larva to pupa. The change is accompanied by a lowering of the supercooling points (spontaneous freezing points) and an increase in the resistance to inoculative freezing. The present study demonstrated that the change in cold-hardiness accompanied by puparium formation is artificially induced by 20-hydroxyecdysone treatment. In the beginning of the puparium formation, the insects lowered their supercooling points and lost their freeze tolerance, becoming resistant to inoculative freezing. At 25°C, the serial changes were completed within a week of the hormonal treatment.
Research and Development of a Novel Insecticide 'pyridalyl' (2005)

Pyridalyl was discovered and has been under worldwide development by Sumitomo Chemical Co., Ltd. It was already registered in some Asian countries in 2004, including Japan. This novel insecticide exerts excellent control against various lepidopterous and thysanopterous pests on cotton and vegetables. Many existing insecticide-resistant strains of lepidopterous pests can be adequately controlled by pyridalyl as well as susceptible strains. Since pyridalyl develops quite unique insecticidal symptoms, it is considered that pyridalyl has a different mode of action from any other existing insecticide. Its excellent safety to mammals and various beneficial arthropods would provide us with an important tool in IPM (Integrated Pest Management).
Solitary Oxygen Dopant Emission from Carbon Nanotubes Modified by Dielectric Metasurfaces (2017)

All-dielectric metasurfaces made from arrays of high index nanoresonators supporting strong magnetic dipole modes have emerged as a low-loss alternative to plasmonic metasurfaces. Here we use oxygen-doped single-walled carbon nanotubes (SWCNTs) as quantum emitters and couple them to silicon metasurfaces to study effects of the magnetic dipole modes of the constituent nanoresonators on the photoluminescence (PL) of individual SWCNTs. We find that when in resonance, the magnetic mode of the silicon nanoresonators can lead to a moderate average PL enhancement of 0.8-4.0 of the SWCNTs, accompanied by an average increase in the radiative decay rate by a factor of 1.5-3.0. More interestingly, single dopant polarization experiments show an anomalous photoluminescence polarization rotation by coupling individual SWCNTs to silicon nanoresonators. Numerical simulations indicate that this is caused by modification of near-field polarization distribution at certain areas in the proximity of the silicon nanoresonators at the excitation wavelength, thus presenting an approach to control emission polarization. These findings indicate silicon nanoresonators as potential building blocks of quantum photonic circuits capable of manipulating PL intensity and polarization of single photon sources.
Voltage resonant buck-boost converter using multi-layer-winding transformer (2003)

A multilayer-winding transformer made of a planar conductor and insulator has a small leakage inductance and a large winding capacitance between the terminals. This winding capacitance causes an undesirable oscillation in the conventional voltage resonant buck-boost converter. A novel type of voltage resonant buck-boost converter which has the resonant inductor in the secondary side of the transformer is presented. This converter can utilize the winding capacitance as part of the resonant capacitor without making the operation complex.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Table S1 from X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis (2023)

&lt;p&gt;Frequency of KDM6A, UTY, KDM5C and KDM5D genetic alterations in cancers with sex-biased and unbiased incidence&lt;/p&gt;
Cellular therapy: an introduction. (2002)

Cellular therapy is defined as the transfer, to the intact host, of living cells with the intent of introducing new host functions or correcting defective functions. The appeal and the promise of cellular therapy derive from the ability to manipulate, ex vivo, cellular and molecular biologic pathways in a way that is not possible in the intact organism.
High-resolution ultrasonic brain imaging: Noninvasive adaptive focusing based on twin arrays (2004)

Ultrasonic imaging systems assume a constant acoustic velocity in human tissues in the beamforming process. However, in the case of brain imaging, strong skull aberrations induce a displacement of the focal stain, a spreading in the main lobe, and an increase in the sidelobes level. This limits considerably ultrasonic brain imaging applications. It has been shown that a very accurate focusing could be achieved through a human skull by using an inverse filter technique. This method, based on a set of acoustic sensors located inside the brain, demonstrated invasively that it was possible to achieve high-resolution brain imaging. A noninvasive ultrasonic method is presented. It is based on two arrays located on each side of the head. Each array focuses on the other one to deduce the aberrations induced by the skull bone. Once the effect of the skull bone in front of each array is extracted, the wavefronts are corrected and emitted. This noninvasive technique restores the position of the focal stain and lowers the secondary lobe level up to 15 dB compared to a cylindrical focusing.
Kounis Syndrome: An Allergic Acute Coronary Syndrome Due to a Bee Sting (2022)

Kounis syndrome, also known as allergic acute coronary syndrome, is defined as the occurrence of acute coronary syndrome (ACS) in the setting of an allergic or hypersensitivity reaction. Although Kounis syndrome is not an uncommon disease, many cases go undiagnosed or unrecognized. Patients with systemic allergic reactions associated with evidence of ACS should be suspected of Kounis syndrome because the outcome could be devastating if not treated promptly. The physician must be aware of Kounis syndrome because the treatment modality differs from traditional ACS.
Preventing Leg Length Discrepancy and Instability After Total Hip Arthroplasty. (2016)

Restoration of equal leg lengths and dynamic hip stability are essential elements of a successful total hip arthroplasty. A careful clinical examination, a preoperative plan, and appropriate intraoperative techniques are necessary to achieve these goals. Preoperative identification of patients at risk for residual leg length discrepancy allows surgeons to adjust the surgical approach and/or the type of implant and provide better preoperative patient education. The use of larger femoral heads, high-offset stem options, and enhanced soft-tissue repairs have improved impingement-free range of motion as well as dynamic hip stability and have contributed to an overall reduction in dislocation. Methods for accurate leg length restoration and component positioning include anatomic landmarks, intraoperative radiographs, intraoperative calipers, stability testing, and computer-assisted surgery. If recurrent instability occurs after total hip arthroplasty, the underlying cause for dislocation should be identified and treated; this may include the use of semiconstrained dual-mobility or fully constrained liners, depending on abductor function. Surgeons should be aware of the clinical and surgical techniques for achieving leg length equalization and dynamic hip stability in total hip arthroplasty.
Predictors of mucoid Pseudomonas colonization in cystic fibrosis patients (2008)

Female gender, number of DF508 alleles, decreased lung function, and lack of S. aureus on recent sputum culture are important risk factors for early detection of mucoid P. aeruginosa.
Synthesis and Structures of Heterocyclic Azidogallanes [(CH3)ClGaN3]4and [(CH3)BrGaN3]3en Route to [(CH3)HGaN3]x:  An Inorganic Precursor to GaN (2000)

The synthesis of [(CH3)ClGaN3]4 (1) with a heterocyclic cyclooctane-like structure and [(CH3)BrGaN3]3 (2) with a trimeric structure has been demonstrated. X-ray structural determinations reveal that 1 and 2 consist of Ga4N4 eight-membered rings and Ga3N3 six-membered rings, respectively, in which the Ga atoms are bridged by the alpha nitrogens of the azide groups. [(CH3)ClGaN3]4 crystallizes in the tetragonal space group P42(1)c with a = 11.017(4) A, c = 8.699(7) A, and Z = 8. [(CH3)BrGaN3]3 crystallizes in the triclinic space group P1 with a = 8.1080(10) A, b = 9.9390(13) A, c = 10.4439(13) A, alpha = 86.069(3) degrees, beta = 86.771(3) degrees, gamma = 80.829(2) degrees, and Z = 6. The reaction of 1 and 2 with LiGaH4 yields [(CH3)HGaN3]x, which is a new low-temperature source of GaN.
Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy (2007)

The relationship between periodontitis and two measures of systemic inflammation, serum albumin and C-reactive protein (CRP), were examined among patients who were receiving chronic outpatient hemodialysis. Adult patients at two locations, North Carolina and New York City, were evaluated by dentist examiners. Six sites per tooth (up to 32 teeth per patient) were examined. A periodontitis case was defined as > or = 60% of sites with attachment level > or = 4 mm. Multivariable logistic regression was used to determine the association of periodontitis with low serum albumin, defined as < 3.5 mg/dl, and with high CRP, defined as > 3.0 mg/dl. A total of 154 patients completed the study. The mean age was 54.6 yr (SD 13.3), and average duration of dialysis was 4.0 yr (3 mo to 16 yr). Eighty-six (54.6%) were men, and 89 (58.2%) were black. Common causes of end-stage kidney disease were hypertension (12.3%), diabetes (22.1%), glomerulonephritis (7.1%), and other (58.4%). The average number of teeth was 20.3 (SD 8.4). Thirty-five (23%) patients were periodontitis cases. Severe periodontitis was associated with low serum albumin (odds ratio 8.20; 95% confidence interval 1.61 to 41.82; P = 0.01) compared with individuals without severe periodontitis disease after adjustment for age, gender, race, diabetes, hypertension, body mass index, smoking, study site, total cholesterol, serum calcium, serum phosphorus, and normalized protein catabolic rate. There was no observed association of severe periodontitis with CRP. Investigation of the potential contribution of periodontitis to serum albumin and possibly to morbidity and mortality among patients with end-stage kidney disease seems warranted.
All Redox‐Active 2D MXene and 0D Phosphomolybdic Acid Nanoclusters‐Anchored Polypyrrole Nanotubes for High‐Performance Aqueous Hybrid Supercapacitors (2022)

Abstract The construction of a hybrid supercapacitor (HSC) with 2D Ti 3 C 2 T x MXene anode is restricted by the scarcity of promising cathode materials that can demonstrate the superior electrochemical features in protic electrolytes. To circumvent this issue, we demonstrate an innovative high‐performance HSC cell in a protic electrolyte by combining a redox‐active 0D phosphomolybdic acid (PMo 12 ) nanoclusters‐anchored polypyrrole nanotubes (PMo 12 /PPyNT) cathode against the pseudocapacitive Ti 3 C 2 T x MXene anode. Decorating PMo 12 , a Keggin‐type polyoxometalates material known for their high redox activities on polypyrrole nanotubes (PPyNT) resulting in a nanocomposite that matches the electrochemical performance of MXene in a protic electrolyte so that a high‐performance HSC cell can be acquired. The gathered PMo 12 /PPyNT//MXene HSC cell delivers the specific energy (36.1 Wh/kg) and specific power (6.66 kW/kg) superior to the state‐of‐the‐art MXene‐based supercapacitor (SC) cells. The cell also exhibits impressive coulombic efficiencies over various current densities and adequate stability over 5000 charge‐discharge cycles. These results show that combining polyoxomolybdate‐based cathode materials against the MXene anode can overcome the boundaries associated with the existing HSC cells.
Three-dimensional display technologies satisfying "super multiview condition" (2001)

The 3D research project has been developing the 3D display system in which natural obserbation is realized in Telecommunication Advancement Organization (TAO) in Japan. Here, recent results are mentioned. The researches are mainly classified in three parts. The first research is the development of 3D display apparatus that realizes super-multi-view condition. The second one is the development of image processing system which generates the super-multi-view video signals. The third is the research to measure the eye control states when super-multi-view 3D images are observed, and the development of the measuring system.
Differential display identifies overexpression of the USP36 gene, encoding a deubiquitinating enzyme, in ovarian cancer (2008)

USP36 is overexpressed in ovarian cancer compared to normal ovary and its transcripts were identified in ascites and serum of ovarian cancer patients.