gebhart/patrepeval huggingface dataset:
A Finite Volume Method for Fluorescence Diffuse Optical Tomography: Influence on Forward Model and Reconstruction (2010)

This paper presents a finite volume method to compute the forward model in fluorescence diffuse optical tomography. The method is compared to the finite element method in regards of both forward model and reconstruction accuracy.
Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening (2017)

TNFα is a homotrimeric pro-inflammatory cytokine, whose direct targeting by protein biotherapies has been an undeniable success for the treatment of chronic inflammatory diseases. Despite many efforts, no orally active drug targeting TNFα has been identified so far. In the present work, we identified through combined in silico/in vitro/in vivo approaches a TNFα direct inhibitor, compound 1, displaying nanomolar and micromolar range bindings to TNFα. Compound 1 inhibits the binding of TNFα with both its receptors TNFRI and TNFRII. Compound 1 inhibits the TNFα induced apoptosis on L929 cells and the TNFα induced NF-κB activation in HEK cells. In vivo, oral administration of compound 1 displays a significant protection in a murine TNFα-dependent hepatic shock model. This work illustrates the ability of low-cost combined in silico/in vitro/in vivo screening approaches to identify orally available small-molecules targeting challenging protein-protein interactions such as homotrimeric TNFα.
Photopolymerization of Acrylonitrile by Potassium TrisoxalatocobaItate(III) in Aqueous Perchloric Acid (1978)

Abstract Results of a kinetic study on photopolymerization of acrylonitrile by potassium trisoxalatocobaltate(II1) in aqueous perchloric acid medium (pH = 1) by use of light of 365 nm wavelength at 30 |Mg 0.1°C are presented. All reactions were carried out under completely deaerated conditions. Certain important features of the photopolymerization are described. The rate of polymerization Rp was followed by gravimetric estimation of polymer formed and rate of disappearance of complex - Rc by spectrocolorometric estimation of complex disappearing. Rp was found to be directly proportional to [M]3/2, kε 1/2, and I1/2, where P[M], kε, and I refer to concentration of acrylonitrile, light absorption fraction of the complex, and light intensity, respectively. -Rc was found to be directly proportional to kε and I. A reaction scheme is drawn and kinetic expressions derived on the basis of that scheme are given.
New class of control laws for robotic manipulators Part 2. Adaptive case (1988)

A new class of asymptotically stable adaptive control laws is introduced for application to the robotic manipulator. Unlike most applications of adaptive control theory to robotic manipulators, this analysis addresses the non-linear dynamics directly without approximation, linearization, or ad hoc assumptions, and utilizes a parameterization based on physical (time-invariant) quantities. This approach is made possible by using energy-like Lyapunov functions that retain the non-linear character and structure of the dynamics, rather than simple quadratic forms, ubiquitous in adaptive control literature, which have bound the theory tightly to linear systems with unknown parameters. It is a unique feature of these results that the adaptive forms arise by straightforward certainty equivalence adaptation of their non-adaptive counterparts found in Wen and Bayard (1988)—i.e. by replacing unknown quantities by their estimates—and that this simple approach leads to asymptotically stable closed-loop adaptive systems. Furthermore, it is emphasized that this approach does not require convergence of the parameter estimates (i.e. via persistent excitation), invertibility of the mass matrix estimate, or measurement of joint accelerations.
Comparing ramp rate control method for PV-energy storage systems in cascaded and parallel architectures (2016)

Energy storage systems (ESS) are broadly employed to smooth out the fluctuation in the PV output caused by cloud passing, or variability of solar irradiance with a high ramp rate. This paper compares the smoothing operation, and ramp rate control in two different architectures: cascaded and parallel topologies. Parallel architecture with reduced number of power switches, simpler controller, and as a retrofit for common three phase inverters improves the obtained efficiency, however cascaded architecture in which two PV and ESS modules are connected in series provides better flexibility, and faster response time to ramp rate variations. In this paper, detailed comparison of the architectures is explained and their performance to reduce the ramp rate is investigated.
Variations in severity of hypertension in a large pedigree with glucocorticoid-remediable aldosteronism (1993)

1Clinical Pharmacology Unit, Department of Medicine and Therapeutics, University of Aberdeen, UK *Howard Hughes Medical Institute, Salt Lake City, Utah, USA
PDMS membranes containing ZIF-coated mesoporous silica spheres for efficient ethanol recovery via pervaporation (2016)

The design of functional micro- and mesostructured MSS–ZIF composite materials for improved bioethanol recovery.
Thermal partial oxidation of n-butane in a micro-flow reactor and solid oxide fuel cell stability assessment (2022)

The direct use of n-butane in solid oxide fuel cell (SOFC) systems has been challenging due to high performance degradation and/or failure due to carbon deposition on the anode. Previous works have explored SOFCs with expensive integrated catalysts to promote the longevity of the SOFC, but few have achieved significant operating hours. In this work, a SOFC with no integrated catalyst is fed n-butane for 288 h utilizing a novel micro fuel reformer. The impact of temperature (800–900 °C), total flow rate (10–50 mL.min−1), and equivalence ratio (1–5) on the thermal partial oxidation of n-butane in the micro-flow reactor are characterized. A literature review of n-butane fueled SOFC systems confirms that the 288-hour long term stability test achieved in this study is among the longest conducted with a low voltage degradation of 0.00034 V.h−1. Scanning electron microscope (SEM) images of the SOFC anode confirm no carbon deposition occurred on the surface. Microscale partial oxidation with light internal reforming provides an alternative to traditional catalytic oxidation and internal reforming SOFC systems.
Expression of activation antigens, HLA-DR and CD38, on CD8 lymphocytes during HIV-1 infection (1992)

There is a stage-associated pattern of HLA-DR and CD38 expression on CD8 T-lymphocytes during HIV infection; specific phenotypic patterns may have functional correlates in the host response to the virus.
Site-Specific Incorporation of the Mucin-Type N-Acetylgalactosamine-α-O-threonine into Protein in Escherichia coli (2009)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionSite-Specific Incorporation of the Mucin-Type N-Acetylgalactosamine-α-O-threonine into Protein in Escherichia coliRan Xu, Sarah R. Hanson, Zhiwen Zhang, Yu-Ying Yang, Peter G. Schultz*, and Chi-Huey Wong*Cite this: J. Am. Chem. Soc. 2009, 131, 38, 13883Publication Date (Web):September 4, 2009Publication History Received14 August 2009Published online4 September 2009Published inissue 30 September 2009https://pubs.acs.org/doi/10.1021/ja906705ahttps://doi.org/10.1021/ja906705acorrectionACS PublicationsCopyright © 2009 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views3358Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (48 KB) Get e-AlertscloseSUBJECTS:Bacteria,Genetics,Monomers,Peptides and proteins,Protein dynamics Get e-Alerts
Transaction Processing (2004)

In broadest computing terms, transaction processing describes the activity performed by a computer upon the introduction of an external stimulus, usually data. A transaction consists of a collection of functionally related data elements in combination with a signal that is either explicit (often referred to as a transaction code) or implied through the context of the application. The transaction code requests that a particular operation be performed in regard to the associated data elements.
A NEW CONCEPT IN THE STABILIZATION OF INJECTABLE FLUOROCARBON EMULSIONS: THE USE OF MIXED FLUOROCARBON-HYDROCARBON DOWELS. (1992)

ABSTRACT A new means of stabilizing fluorocarbon in water emulsions is reported. It uses mixed fluorocarbon/hydrocarbon amphiphiles, acting as molecular dowels, to reinforce the binding between the fluorocarbon phase and its surrounding lipidic membrane. In an example, perfluorooctylbromide/phospholipid emulsions (90/4 % w/v) stabilized by C8F17CH=CHC8H17 (2.8 % w/v) remain stable, with no significant increase in particle sizes (after the initital equilibration period) for 9 months at 40°C.
CW passive mode-locking evolved from Q-switched mode-locking in erbium doped fiber lasers (2003)

Summary form only given. We report a new mode-locking mechanism, where the use of a two-photon absorber in addition to a saturable absorber allows for CW mode-locking to reliably evolve from Q-switched mode locking. An optimal design of the two-photon absorber limits the peak power of the Q-switched pulses via optical limiting and thus aids in preventing damage to the saturable absorber. Moreover, the threshold for optical limiting is chosen to set an optimum stability point for CW mode-locked operation.
Complete Genome Sequence of Moraxella catarrhalis Strain CCRI-195ME, Isolated from the Middle Ear (2017)

<i>Moraxella catarrhalis</i> is an important bacterial pathogen that causes otitis media and exacerbations of chronic obstructive pulmonary disease. Here, we report the complete genome sequence of <i>M. catarrhalis</i> strain CCRI-195ME, which contains the phase-variable epigenetic regulator ModM3.
Detection of number of two-dimensional cisoids for array processing algorithms (2003)

We present a new minimum description length type criterion for the problem of inferring the number of 2D complex sinusoids (cisoids) present in observed data contaminated by white Gaussian noise. The criterion does not require estimation of the 2D frequencies or selection of any subjective threshold parameters, and it is shown to be consistent. An application to the detection of the number of coherent signals in a 2D antenna array processing scenario illustrates the good complexity-performance trade-off of the proposed method.
Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation (2020)

Multidonor antibodies are of interest for vaccine design because they can in principle be elicited in the general population by a common set of immunogens. For influenza, multidonor antibodies have been observed against the hemagglutinin (HA) stem, but not the immunodominant HA head. Here, we identify and characterize a multidonor antibody class (LPAF-a class) targeting the HA head. This class exhibits potent viral entry inhibition against H1N1 A/California/04/2009 (CA09) virus. LPAF-a class antibodies derive from the HV2-70 gene and contain a "Tyr-Gly-Asp"-motif, which occludes the HA-sialic acid binding site as revealed by a co-crystal structure with HA. Both germline-reverted and mature LPAF antibodies potently neutralize CA09 virus and have nanomolar affinities for CA09 HA. Moreover, increased frequencies for LPFA-a class antibodies are observed in humans after a single vaccination. Overall, this work highlights the identification of a multidonor class of head-directed influenza-neutralizing antibodies and delineates the mechanism of their recurrent elicitation in humans.
Long QT, alteration of calcium-phosphate product, prevalence of ventricular arrhythmias and sudden death in peritoneal dialysis patients: a Holter study (2013)

Materials and methods We studied 79 patients on peritoneal dialysis. Each underwent 24-h electrocardiography (Holter monitoring) and measurement of the rate-corrected QT interval (QTc). We analyzed the correlation between QTc and plasma levels of Ca++, PO4−, K+, Na+, Mg++, and parathyroid hormone (PTH). Results The mean QTc was 0.445 ± 0.04 s. In 55 patients, the QTc was prolonged (&gt; 0.45 s). Mean laboratory values for the group were: PTH 344 ± 25 pg/mL, Ca++ 9.27 ± 0.11 mg/dL, PO4− 5.5 ± 1.5 mg/dL, Na+ 139.6 ± 3.4 mmol/L, K+ 4.04 ± 0.64 mmol/L, and Mg++ 2.52 ± 0.43 mg/dL. Holter monitoring revealed complex premature ventricular contractions in 44 patients, monomorphic premature ventricular contractions in 16, and nonsustained ventricular tachycardia (NSVT) in 10. The QTc was significantly correlated with plasma levels of PO4− (r = 0.045, p &lt; 0.05), PTH (r = 0.077, p &lt; 0.02), and Ca++ (r = 0.076, p &lt; 0.02). Eleven patients had Lown class 4a or 4b ventricular arrhythmias, and their mean QTc was 465 ± 0.02 ms. Ten had NSVT and their QTc was 464 ± 0.03 ms. Eleven patients died suddenly (mean QTc 465 ± 0.03 ms); all 11 had either NSTV or Lown class 4 ventricular arrhythmias. Conclusions Long QTc seems to be associated with an increased prevalence of ventricular arrhythmias that may be the cause of sudden cardiac death.
Localisation de défauts dans les circuits intégrés complexes dont le dessin des masques est inconnu (1998)

Ce memoire presente des methodes et techniques innovantes pour la localisation de defauts dans les circuits integres complexes dont le dessin des masques est inconnu. Les avancees proposees repondent a un besoin rencontre pour l'analyse de defaillance des circuits commerciaux et programmables. Une revue de l'etat de l'art des techniques de localisation par contraste de potentiel a mis en evidence l'absence de techniques ou methodes pour repondre efficacement et dans des delais brefs a ce defi de localisation. Le logiciel image fault analysis (ifa) implante sur les testeurs par faisceau d'electrons ids 5000 offre les bases d'une methode de localisation par comparaison d'images entre un circuit defaillant et un circuit de reference. En s'appuyant sur ifa, nous avons evalue de facon pratique et theorique la duree de localisation et les parametres mis en jeux, tels que la surface du circuit, le nombre de vecteurs et le temps de changement de circuits. Basees sur cette etude, nous avons developpe deux approches : ifa dichotomie qui ramene la duree de localisation de plusieurs mois avec ifa automatique (methode de base sur l'ids) a moins d'une semaine (28 h machine) pour un circuit programmable fpga d'une taille de 1 cm#2 et ifa backtracing qui reduit cette duree a moins de huit heures pour le meme circuit dans le cas d'un fonctionnement marginal (le meme circuit peut etre mis dans une configuration defaillante ou fonctionnelle). Pour aller plus loin et reduire encore la duree de la localisation, des informations supplementaires ont alors ete injectees permettant le developpement d'approches novatrices telles que : - la localisation assistee par le test i#d#d#q, - la localisation assistee par la simulation electrique pour le test interne, - la localisation assistee par la generation d'un pseudo-layout. Cette derniere approche, dans le cas d'un circuit a1280 permet, grace a la technique de la selection de signaux (que nous avons implantee sur l'ids), de s'affranchir de la contrainte du mode image pour acceder aux outils de navigation, simulation et mesure comme pour un asic pour lequel le dessin des masques est accessible.
A low-cost SiGe:C BiCMOS technology with embedded flash memory and complementary LDMOS module (2005)

We present a low-cost, modular BiCMOS process for wireless and mixed-signal applications. A SiGe:C bipolar module, a complementary LDMOS module, and a low-power flash memory were combined with a 0.25/spl mu/m CMOS technology to enable SoC integration. The low-cost approach is demonstrated by the fact that only 29 mask steps are applied in total for the full process flow including all modules, a full suite of passives, and 5 metal layers.
A Comparison of SC-FDE and UW DFT-s-OFDM for Millimeter Wave\n Communications (2018)

In this study, we compare the single-carrier (SC) waveform adopted in IEEE\n802.11ad and unique word discrete Fourier transform spread orthogonal frequency\ndivision multiplexing (UW DFT-s-OFDM) waveform. We provide equivalent\nrepresentations of up-sampling and down-sampling operations of the SC waveform\nby using discrete Fourier transform (DFT) and inverse DFT to enable explicit\ncomparison of these two similar waveforms. By using this representation, we\ndiscuss why the IEEE 802.11ad SC waveform can cause suboptimal performance in\nmultipath channel and discuss how to improve it with UW DFT-s-OFDM. With\ncomprehensive link-level simulations, we show that replacing the 802.11ad SC\nwaveform with UW DFT-spread OFDM can result in 1 dB gain in peak throughput\nwithout affecting the IEEE 802.11ad packet structure. We also evaluate the\ncross links where the transmitter is UW-DFT-s-OFDM and the receiver is\ntraditional SC-FDE or vice versa. We demonstrate that UW DFT-s-OFDM receiver\ncan decode an IEEE 802.11ad SC waveform with a slight SNR loss while IEEE\n802.11ad SC receiver can decode a UW DFT-spread OFDM waveform with an\ninterference floor.\n
Development of Physiologically Relevant Methods for Assessing Inhibition of Glycoprotein Virulence Factors by Small Molecules in Human Pathogen Campylobacter jejuni (2016)

Campylobacter jejuni is a major cause of gastroenteritis, often resulting in death of the young, elderly and immunocompromised. Campylobacteritis also may result in complications leading to autoimmune and neurological disorders such as Guillain‐Barre syndrome. In this organism, a consistent structure‐function relationship has emerged in recent years: the importance of N ‐linked protein glycosylation for bacterial pathogenic and colonization behaviors in avians and mammals. However, the biochemical roles and molecular mechanisms of C. jejuni N ‐glycans in the infection of human intestinal epithelium are not understood. Our laboratory has developed small molecule inhibitors of critical biosynthetic enzymes in the N ‐glycosylation pathway (pgl pathway), acting on their respective targets with up to nM affinity in vitro . Assessing the efficacy of small molecule inhibitors of protein glycosylation in vivo with microaerophilic Gram‐negative organisms has proven difficult. To this end, we have pursued several efficient, quantitative and broadly applicable strategies for assessing glycosylation inhibition and any downstream effects on bacterial pathogenicity. We have developed conditions for C. jejuni culture in the presence of small molecule inhibitors and subsequent quantification of protein glycosylation via immunoassay. In addition, inhibitors of biosynthetic enzymes in the pgl pathway are also assessed in vivo utilizing E. coli strains expressing C. jejuni protein glycosylation pathway enzymes, providing additional insight into the effects of outer membrane composition on inhibitor permeability. Lastly, in collaboration with the Griffith lab, we are developing methods for the characterization of C. jejuni pathogenicity using a unique co‐culture platform bearing polarized human gut epithelial monolayers comprised of enterocyte (Caco2), mucin‐producing goblet cells (HT29‐MTX), and immune cells (dendritic cells). This “gut chip” platform, providing histological, fluorometric and immunological readouts, will be critical for monitoring the adhesion and invasion of C. jejuni strains with attenuated glycosylation patterns and can be easily be turned toward the investigation of pathogenicity in other organisms. These multifaceted approaches will provide useful molecular detail and phenotypic characterization toward the further development of this new class of inhibitors and a greater understanding of mechanisms behind pathogenesis. Support or Funding Information This work is supported by the National Institutes of Health (R01‐‐GM097241 and R03‐MH096549 to B.I.) and the Belgian American Exchange Fellowship.
High precision actuator control (2002)

We consider the controller design problem when the input signal is known in advance and the performance is measured as maximum absolute tracking error. We design a two-parameter controller that allows one to achieve very precise nominal tracking while keeping the control input rate within desired limits. We apply the method to a first example and uncover the structure of the controller parameters. Finally, we apply the method to a realistic model of actuator for micro-surgery. The simulation results show that the design method can be used successfully to impose stringent time-domain specifications on the resulting closed loop system.
Prediction of solid-state amorphizing reaction using effective driving force (1995)

It is proposed that the nucleation and growth of the amorphous phase through the solid-state amorphizing reaction in thin-film diffusion couples can be predicted by using the concept of effective driving force. The effective driving force consists of two factors: (i) the thermodynamic driving force given by maximum free-energy difference between the physical mixture of binary elements and the amorphous phase (ΔGmax), and (ii) the kinetic factor given by a ratio of the effective radius of the interstitial site in the host matrix to the atomic radius of the diffusing species (Rm/d). From the comparison of reported experimental results, it is shown that the criterion of effective driving force holds well for predicting the nucleation of the amorphous phase in metal/silicon systems as well as that of metal/metal systems. In addition, the concept of effective driving force holds well for predicting the growth tendency of the amorphous phase in metal/silicon systems.
Complex requirements for RNA poIymerase III transcription of theXenopusU6 promoter (1990)

The role of various sequences in determining the RNA polymerase III (pol III) specificity of the Xenopus U6 gene promoter has been investigated. A sequence closely resembling an RNA polymerase II (pol II) TATA box, which has previously been implicated in determining the pol III specificity of the U6 promoter, was analyzed in detail. The U6 TATA-like element, in a different promoter context, is shown to be capable of mediating RNA polymerase II transcription both in vitro and in oocyte microinjection experiments. Extensive mutagenesis of the TATA-like element in the context of the pol III and pol II promoters leads to the conclusion that the sequence requirements for function in the two contexts are dissimilar, suggesting that different factors may be involved in mediating pol II and pol III transcription. Further, as implied by the above results, it is shown that the polymerase III specificity of the U6 gene is not solely dependent upon the TATA-like element but rather reflects complex interaction between multiple components of the promoter.