gebhart/patrepeval huggingface dataset:
Bias and precision analysis of diffusional kurtosis imaging for different acquisition schemes (2016)

The noise bias behavior of DKI is highly complex and can cause overestimation as well as underestimation of the AKC even within one voxel. The acquisition scheme with three shells, suggested by Poot et al, provided overall the best performance. Magn Reson Med 76:1684-1696, 2016. © 2016 International Society for Magnetic Resonance in Medicine.
ECONOMIC EVALUATION OF INTRAVENOUS IODINATED CONTRAST MEDIA IN ITALY (2014)

Base-case results show that IV iodixanol is cost-effective compared with LOCM in the Italian clinical setting of a hospital computed tomography radiology practice. However, some caution is due, mainly linked to inherent limitations of the modeling technique and to the lack of agreement on CI-AKI incidence data in the clinical literature.
Caries Excavation - How do you do it? (2017)

status: Published
Dendritic cell–targeted lentiviral vector immunization uses pseudotransduction and DNA-mediated STING and cGAS activation (2017)

Dendritic cell (DC) activation and antigen presentation are critical for efficient priming of T cell responses. Here, we study how lentiviral vectors (LVs) deliver antigen and activate DCs to generate T cell immunization in vivo. We report that antigenic proteins delivered in vector particles via pseudotransduction were sufficient to stimulate an antigen-specific immune response. The delivery of the viral genome encoding the antigen increased the magnitude of this response in vivo but was irrelevant in vitro. Activation of DCs by LVs was independent of MyD88, TRIF, and MAVS, ruling out an involvement of Toll-like receptor or RIG-I-like receptor signaling. Cellular DNA packaged in LV preparations induced DC activation by the host STING (stimulator of interferon genes) and cGAS (cyclic guanosine monophosphate-adenosine monophosphate synthase) pathway. Envelope-mediated viral fusion also activated DCs in a phosphoinositide 3-kinase-dependent but STING-independent process. Pseudotransduction, transduction, viral fusion, and delivery of cellular DNA collaborate to make the DC-targeted LV preparation an effective immunogen.
Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents (2010)

An iridium catalysed oxidation was coupled concurrently to an asymmetric biocatalytic reduction in one-pot; thus it was shown for the first time that iridium- and alcohol dehydrogenase-catalysed redox reactions are compatible. As a model system racemic chlorohydrins were transformed to enantioenriched chlorohydrins via an oxidation-asymmetric reduction sequence.
Petapixel photography and the limits of camera information capacity (2013)

The monochromatic single frame pixel count of a camera is limited by diffraction to the space-bandwidth product, roughly the aperture area divided by the square of the wavelength. We have recently shown that it is possible to approach this limit using multiscale lenses for cameras with space bandwidth product between 1 and 100 gigapixels. When color, polarization, coherence and time are included in the image data cube, camera information capacity may exceed 1 petapixel/second. This talk reviews progress in the construction of DARPA AWARE gigapixel cameras and describes compressive measurement strategies that may be used in combination with multiscale systems to push camera capacity to near physical limits.
Accurate self-characterization of mismatches in a capacitor array of a digitally-controlled oscillator (2010)

A programmable self-characterization technique is presented, whose purpose is to determine the extent of mismatches present in a variable-capacitor (varactor) array as part of an LC tank of a digitally controlled oscillator (DCO). The varactor array represents a digital-to-analog conversion function, such that mismatches in it cause distortion in the DCO's digital frequency tracking and modulation. The presented technique, relying exclusively on internal resources in the system-on-chip (SoC) and on dedicated software, is implemented in a 65 nm CMOS Digital RF Processor (DRP) based transceiver, and demonstrates sufficient accuracy to allow relatively quick measurements of mismatches of a few percent.
The role of hospital medical teams at a major accident* (1975)

Despite an apparently adequate major accident plan which has been used successfully on two previous occasions, considerable difficulties were experienced by the mobile medical teams at the scene of the Moorgate tube train accident. The authors have attempted to describe the role and organisation of mobile medical teams placing particular emphasis on a simple and flexible plan.
Fast-atom bombardment-tandem mass spectrometry studies of organo-alkali-metal ions of small peptides. Competitive interaction of sodium with basic amino acid substituents (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFast-atom bombardment-tandem mass spectrometry studies of organo-alkali-metal ions of small peptides. Competitive interaction of sodium with basic amino acid substituentsDavid H. Russell, E. S. McGlohon, and L. M. MallisCite this: Anal. Chem. 1988, 60, 17, 1818–1824Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://doi.org/10.1021/ac00168a034RIGHTS & PERMISSIONSArticle Views120Altmetric-Citations84LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (907 KB) Get e-Alerts Get e-Alerts
ChemInform Abstract: SYNTHESIS OF 1,4‐BENZODIAZEPIN‐2‐ONE AND 4‐PHENYLQUINOLINE. NEW METHOD FOR QUINOLINE RING CYCLIZATION (1979)

Abstract Aus den Nitrobenzoesäuren und Nitrobenzophenonen (I) werden durch Cyclisierung mit Benzylcyanid (II) die Anthranile (III) hergestellt.
ChemInform Abstract: Radical Decarboxylative Alkylation of Tartaric Acid. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Epigenetic silencing of miR-145-5p contributes to brain metastasis (2015)

Brain metastasis is a major cause of morbidity and mortality of lung cancer patients. We assessed whether aberrant expression of specific microRNAs could contribute to brain metastasis. Comparison of primary lung tumors and their matched metastatic brain disseminations identified shared patterns of several microRNAs, including common down-regulation of miR-145-5p. Down-regulation was attributed to methylation of miR-145's promoter and affiliated elevation of several protein targets, such as EGFR, OCT-4, MUC-1, c-MYC and, interestingly, tumor protein D52 (TPD52). In line with these observations, restored expression of miR-145-5p and selective depletion of individual targets markedly reduced in vitro and in vivo cancer cell migration. In aggregate, our results attribute to miR-145-5p and its direct targets pivotal roles in malignancy progression and in metastasis.
Effects of Estradiol and Progesterone on Epidermal Growth Factor Concentration in Plasma, Bile, Urine, Submandibular Gland and Kidney of the Mouse (1989)

Testosterone is known to increase epidermal growth factor (EGF) concentrations in mouse plasma and submandibular salivary gland. We tested in adult sialoadenectomized (sx) and sham-operated female and male mice our hypothesis that female sex steroids also affect EGF concentrations in fluids and tissues. In 10-day treatment estradiol-17 beta increased the EGF concentration in male urine and in (sx) female plasma. Progesterone increased the concentration in both sexes in plasma (sx mice) and in the kidneys. In contrast, progesterone decreased it in female urine.
Ultrafast Heterodyne Infrared Nano-Imaging of Polaron Dynamics in Lead Halide Perovskites (2021)

Ultrafast heterodyne infrared nano-imaging has been developed to reveal nanoscale heterogeneity of polaron formation, dynamics, and polaron-cation coupling in lead halide perovskites, with real space-time mapping of elementary electron-phonon coupling underlying their optoelectronic response.
Quantitative Analysis of Semiconductor Nanocrystal Ensemble Optical Extinction (2018)

The optical extinction coefficients of localized surface plasmon resonance (LSPR) in doped semiconductor nanocrystals (NCs) have intensities determined by the free charge carrier concentration and the mechanisms for damping the oscillation of those free carriers. We investigate the dependence of the extinction coefficient of tin-doped indium oxide (ITO) NCs on size and dopant concentration and find extinction coefficients as high as 56.5 um-1 in the near infrared for 7.5 atomic% Sn 20 nm diameter ITO NCs. We demonstrate a new fitting procedure for the optical extinction of an ensemble of well-dispersed NCs that accounts for NC size heterogeneity, electron concentration heterogeneity, surface scattering, and near-surface electron depletion due to surface states. The heterogeneous ensemble Drude approximation (HEDA) model utilizes the same number of variables as previous models and fits data as well or better while using inputs and fitting parameters that are described by physical phenomena. The model improves the understanding of free carrier motion in doped semiconductor NCs by more accurately extracting carrier concentration and carrier damping. The HEDA model captures individual NC optical properties and their contributions to the ensemble spectra. We find the peak extinction coefficient of an average NC varies linearly with the product of electron accessible volume fraction and electron concentration, normalized by damping.
Abstract 5342: Somatic bi-allelic loss of TSC genes in eosinophilic solid and cystic renal cell carcinoma (ESC RCC) (2018)

Abstract Renal cell carcinoma (RCC) subtypes with overlapping histomorphologic features pose diagnostic challenges. For instance, a unique category of sporadic renal tumors with eosinophilic cytoplasm and solid and cystic growth pattern (ESC RCC) may mimic a RCC subtype usually encountered in patients with germline aberrations of tuberous sclerosis complex (TSC) genes (TSC RCC). Here, we used next-generation sequencing (NGS) technology to interrogate the clinicopathologic and molecular profiles of ESC RCC tumors. Mutational and copy number analysis of NGS data from ESC RCC tumors revealed a somatic bi-allelic loss of TSC family genes, specifically TSC1 or TSC2, in six out of seven profiled cases. However, the corresponding background kidney showed only wild type alleles, thus excluding any germline involvement and differentiating ESC RCC from TSC RCC. Furthermore, bi-allelic loss of the TSC genes occurred in a mutually exclusively manner in this cohort. Our study clarifies the molecular identity of ESC RCC, and can thus guide future therapeutic strategies and provide a basis for the revision of current RCC classification. Citation Format: Nicole D. Lee, Pankaj Vats, Xuhong Cao, Fengyun Su, Robert Lonigro, Kumpati Premkumar, Kiril Trpkov, Jesse K. McKenney, Rohit Mehra, Saravana M. Dhanasekaran, Arul M. Chinnaiyan. Somatic bi-allelic loss of TSC genes in eosinophilic solid and cystic renal cell carcinoma (ESC RCC) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5342.
Substituent Effects and the Energetics of Noncatalyzed Aryl Halide Aminations: A Theoretical Investigation (2021)

We report the influence of substituents and physical conditions on activation energies for the noncatalyzed amination (C-N cross-coupling reactions) of aryl halides. We uncover a significant correlation between the barrier heights of the C-N bond formation and Hammett σ parameters-a formal measure of the electron-withdrawing or -donating ability of substituents on the aryl halides. Our results indicate that such correlations are useful predictive tools for the amination of aryl halides over a wide range of substituent types. From 54 cases studied (six substituents occupying specific positions relative to halogen atoms), the 2-COOHPhI + NH<sub>2</sub> <i><sup>n</sup></i> Pr amination reaction is predicted to possess the lowest noncatalyzed activation free energy (135.6 kJ mol<sup>-1</sup>) using the B3LYP method. The lower barriers for the 2-COOHPhX (for X = Cl, Br, and I) compounds are shown to originate from collusion between steric and electronic effects-specifically, the momentary formation of a hydrogen bond between an oxygen site on the <i>ortho</i>-COOH and the lone pair of the entering amine. Internal reaction coordinate (IRC) path calculations afforded us these and other key insights into the nature of the reactions. The control exerted by substituents on the arrangement of the transition state structure, as well as the sensitivity of the reaction barriers to temperature and solvent polarity, are discussed. These results offer new perspectives from which to assess the nature of the C-N bond formation and suggest new avenues for future exploration, especially in progress toward the metal-free amination of aryl compounds.
A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease: the Systematic Investigation of Gastrointestinal Diseases in China (2010)

This population-based survey found that the prevalence of symptom-defined GERD in China was 3.1%, which is lower than that found in Western countries.
Between listening and sounding: Exploring the limits of augmented instruments (2022)

This paper explores some of the changed relationships between body and environment that occur when instruments are augmented by electronic or digital circuits. Taking Gregory Bateson’s theorisation of the schizophrenic body (1973) as its starting point, the paper explores situations in which the relationship between the performer, body, and instrument takes on increasingly separate communicational modes, in which the body and its meanings come to resemble the ‘unlabelled metaphor’ of the schizophrenic. A series of instrument/personas are brought before us, representing both the ‘norm’ of acoustic instrumental performances and the extreme limits of instrumental identity, offering critical insight into the space that augmented instruments occupy and transform. In considering some of these changes, and in reaching towards their extremities, attention is paid to the friction or awkwardness that accompanies the metamorphosis. In the same way that the ability of a language to ‘point’ is fraught with inconsistencies and potentials for misunderstanding, so the transformation in instrumental identities does not happen in a smooth and transparent way. However, the changes do create the potential for new sensibilities and forms of critical and ethical awareness.
Image Reconstruction for MRI using Deep CNN Priors Trained without Groundtruth (2020)

We propose a new plug-and-play priors (PnP) based MR image reconstruction method that systematically enforces data consistency while also exploiting deep-learning priors. Our prior is specified through a convolutional neural network (CNN) trained without any artifact-free ground truth to remove under-sampling artifacts from MR images. The results on reconstructing free-breathing MRI data into ten respiratory phases show that the method can form high-quality 4D images from severely undersampled measurements corresponding to acquisitions of about 1 and 2 minutes in length. The results also highlight the competitive performance of the method compared to several popular alternatives, including the TGV regularization and traditional UNet3D.
Forming Limits Prediction of FCC Sheet Metal Adopting Crystal Plasticity (2007)

A rate-dependent crystal plasticity constitutive model together with Marciniak- Kuczynski(M-K) approach is employed to perform numerical simulations of forming limits diagrams(FLDs). An initial imperfection in terms of a narrow band is adopted to initialize the sheet necking. Homogeneous deformations inside and outside the band are assumed and the enforcement of compatibility and equilibrium conditions is required only on the band interface. Constitutive computations are carried out on two aggregates of FCC crystal grains, with each representing one of the two zones, respectively. Taylor homogenization assumption is employed to establish the link of stress between single crystal and polycrystal, and to derive an average response of the aggregates. The same initial texture is imparted to the two aggregates and their evolutions will be traced in the necking process. Factors affecting the FLDs prediction, such as imperfection intensity, initial texture, strain rate sensitivity and crystal elasticity will be taken into account. The above procedure will be applied to an annealed aluminium alloy sheet metal
Torque control of underactuated tendon-driven fingers (2011)

Abstract. Given an underactuated tendon-driven finger, the finger posture is underdetermined and can move freely ("flop") in a region of slack tendons. This work shows that such an underactuated finger can be operated in tendon force control (rather than position control) with effective performance. The force control eliminates the indeterminate slack while commanding a parameterized space of desired torques. The torque will either push the finger to the joint limits or wrap around an external object with variable torque – behavior that is sufficient for primarily gripping fingers. In addition, introducing asymmetric joint radii to the design allows the finger to command an expanded range of joint torques and to scan an expanded set of external surfaces. This study is motivated by the design and control of the secondary fingers of the NASA-GM R2 humanoid hand. This paper was presented at the IFToMM/ASME International Workshop on Underactuated Grasping (UG2010), 19 August 2010, Montréal, Canada.
Estimation of the Slope of the Acoustic Attenuation Coefficient (1984)

In this paper, a theoretical framework is developed which removes the Gaussian assumption commonly used in ultrasonic attenuation estimation based on mean frequency shift. The theory is developed for general non-Gaussian spectra and for media whose attenuation coefficient is nonlinear with frequency. Then, a linear approximation in the estimation of the attenuation coefficient's slope is examined. It is shown that the error due to the linear approximation is negligibly small.
Live demonstration: Characterization of RRAM crossbar arrays at a click of a button (2016)

We demonstrate a desktop platform which has the ability of fully characterizing RRAM crossbar arrays while not compromising on ease-of-use. The setup consists of our bespoke PCB system connected to a local PC (laptop), on which a Pyhton interface allows the user to directly interact with individual RRAM cells packaged in either crossbar or stand-alone configurations. The platform is capable of current-compliant forming among other exotic pulsing schemes, used for exposing IV and switching characteristics or utilising the devices for a wide range of applications. These operations can be applied on one, or several cells, in an automated fashion, drastically accelerating data acquisition.
Tight Linear Convergence Rate of ADMM for Decentralized Optimization (2019)

The present paper considers leveraging network topology information to improve the convergence rate of ADMM for decentralized optimization, where networked nodes work collaboratively to minimize the objective. Such problems can be solved efficiently using ADMM via decomposing the objective into easier subproblems. Properly exploiting network topology can significantly improve the algorithm performance. Hybrid ADMM explores the direction of exploiting node information by taking into account node centrality but fails to utilize edge information. This paper fills the gap by incorporating both node and edge information and provides a novel convergence rate bound for decentralized ADMM that explicitly depends on network topology. Such a novel bound is attainable for certain class of problems, thus tight. The explicit dependence further suggests possible directions to optimal design of edge weights to achieve the best performance. Numerical experiments show that simple heuristic methods could achieve better performance, and also exhibits robustness to topology changes.
Block Interleaver Design for the Single Carrier Modulation in IEEE 802.11ay (2018)

This paper proposes the design of a symbol block interleaver in the time domain for the Single Carrier (SC) modulation. The interleaver scheme is intended to sufficiently improve the system performance during transmission of the high-order Quadrature Amplitude Modulation (QAM) constellations. Considered interleaver configurations are compared by the realized Signal-to-Noise Ratio (SNR) gains in two None-Line-of-Sight (NLoS) channel models: the Rayleigh model and the IEEE 802.11ad channel model. The proposed interleaver allows to achieve the SNR gain of up to 2.6 dB for 64-QAM while keeping low implementation complexity. This solution is already adopted by the IEEE 802.11ay standardization group. In addition, the interleaver design considers permutation of groups of symbols (rather than bits) that facilitates easy parallel hardware implementation.
Mouse Cell‐Mediated Lympholysis Assay in Serum‐Free and Mouse Serum‐Supplemented Media: Culture Conditions and Genetic Factors (1975)

We describe a miniaturized cell‐mediated lympholysis assay for measuring the activity of cytotoxic lymphocytes generated in mouse mixed leukocyte cultures (MLC), using either serum‐free or mouse serum‐supplemented media. Mixed reactions of strain combinations possessing various genetic differences at H‐2 produced cytotoxic lymphocytes with cytolytic activity against cells of the donor used in the sensitization phase. Results suggest that both serologically defined and lymphocyte‐defined determinants can act as effective target antigens on target cells. In contrast, no cytotoxic lymphocytes were generated against products of non‐H‐2 loci–M‐locus, theta, or other non‐H‐2 antigens–that induce MLC activation.