gebhart/patrepeval huggingface dataset:
A coordination polymer of (Ph3P)AuCl prepared by post-synthetic modification and its application in 1-hexene/n-hexane separation (2011)

PCM-10 is a porous phosphine coordination material based on Ca(II) and tris(p-carboxylated) triphenylphosphine. The material provides a unique 3-dimensional surface of P(III) Lewis base sites, which is ideal for post-synthetic functionalization. The addition of Au(I) yields an advanced material that can selectively adsorb 1-hexene over n-hexane at room temperature.
Optimized design for three port transformer considering leakage inductance and parasitic capacitance (2017)

The power flow capability of high frequency phase-shifted dc-dc converter depends on transformer leakage inductance and switching frequency. The design of multi-port transformer requires optimized volume and losses with required leakage inductance for rated power flow. Use of fast-switching SiC devices also demand low inter-winding parasitic capacitance for reduced common mode current. The work in this paper focuses on loss-volume optimized design of three port high frequency transformer integrating PV and Energy Storage(ES) based on leakage inductance and parasitic capacitance model. Two laboratory prototypes of 50kHz and 100kHz operating frequency have been designed to verify the leakage and parasitic capacitance model based design and the losses of the transformers.
Measurements of intense femtosecond laser pulse propagation in air (2005)

The nonlinear self-focusing of an intense femtosecond pulse propagating in air can be balanced by the plasma defocusing as the laser intensity is increased above the threshold for multiphoton ionization. The resultant laser∕plasma filament can extend many meters, suitable for many applications such as remote atmospheric breakdown, laser induced electrical discharge, and femtosecond laser material interactions. Direct (bore-sight) measurements of filament size and fluence over 4 m showed a preservation of the total energy in the filament during propagation. This indicates the energy lost in creating the central plasma column through multiphoton ionization was continuously being replenished from the surrounding radiation. Electrical measurement of the filament conductivity estimated the plasma density to be 1×1016cm−3 and electrical discharges triggered by a femtosecond laser filament were found to occur at substantially reduced breakdown fields.
KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions in cellular interactions (2012)

Click to launch & play an online audio visual presentation by Prof. Eric Vivier on KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions in cellular interactions, part of a collection of multimedia lectures.
Sulfur Chemistry of Asphaltenes from a Highly Compositionally Graded Oil Column (2013)

Hydrocarbons in subsurface reservoirs are generally found to be compositionally graded, with fluids deeper in connected and equilibrated reservoirs being relatively enriched in asphaltenes. These gradients result from effects such as gravity, entropy, and solubility. However, it is unclear if those same effects lead to gradients in the detailed molecular composition of asphaltenes. Here, we investigate the sulfur chemistry of asphaltenes from a reservoir with a large gradient in asphaltene content. Measurements of the sulfur content from combustion as well as measurements of sulfur speciation from K-edge X-ray absorption near edge structure (XANES) spectroscopy find no significant difference in the composition of the asphaltenes. Thus, different locations within this reservoir contain oils with different asphaltene concentrations, but the asphaltenes from throughout the reservoir all have the same sulfur chemistry. This result suggests that gradients in asphaltene content can be successfully modeled with the simplifying assumption that the asphaltene molecular composition is not graded in connected and equilibrated reservoirs.
Bootstrap Calibration and Uncertainty Estimation of Downhole NMR Hydraulic Conductivity Estimates in an Unconsolidated Aquifer (2014)

Characterization of hydraulic conductivity (K) in aquifers is critical for evaluation, management, and remediation of groundwater resources. While estimates of K have been traditionally obtained using hydraulic tests over discrete intervals in wells, geophysical measurements are emerging as an alternative way to estimate this parameter. Nuclear magnetic resonance (NMR) logging, a technology once largely applied to characterization of deep consolidated rock petroleum reservoirs, is beginning to see use in near-surface unconsolidated aquifers. Using a well-known rock physics relationship-the Schlumberger Doll Research (SDR) equation--K and porosity can be estimated from NMR water content and relaxation time. Calibration of SDR parameters is necessary for this transformation because NMR relaxation properties are, in part, a function of magnetic mineralization and pore space geometry, which are locally variable quantities. Here, we present a statistically based method for calibrating SDR parameters that establishes a range for the estimated parameters and simultaneously estimates the uncertainty of the resulting K values. We used co-located logging NMR and direct K measurements in an unconsolidated fluvial aquifer in Lawrence, Kansas, USA to demonstrate that K can be estimated using logging NMR to a similar level of uncertainty as with traditional direct hydraulic measurements in unconsolidated sediments under field conditions. Results of this study provide a benchmark for future calibrations of NMR to obtain K in unconsolidated sediments and suggest a method for evaluating uncertainty in both K and SDR parameter values.
Methylation testing for the detection of recurrent cervical intraepithelial neoplasia (2023)

Women treated for CIN2/3 remain at increased risk of recurrent CIN and cervical cancer, and therefore posttreatment surveillance is recommended. This post hoc analysis evaluates the potential of methylation markers ASCL1/LHX8 and FAM19A4/miR124-2 for posttreatment detection of recurrent CIN2/3. Cervical scrapes taken at 6 and 12 months posttreatment of 364 women treated for CIN2/3 were tested for methylation of ASCL1/LHX8 and FAM19A4/miR124-2 using quantitative multiplex methylation-specific PCR. Performance of the methylation tests were calculated and compared with the performance of HPV and/or cytology. Methylation levels of recurrent CIN were compared between women with a persistent HPV infection, and women with an incident HPV infection or without HPV infection. Recurrent CIN2/3 was detected in 42 women (11.5%), including 28 women with CIN2 and 14 with CIN3. ASCL1/LHX8 tested positive in 13/14 (92.9%) of recurrent CIN3 and 13/27 (48.1%) of recurrent CIN2. FAM19A4/miR124-2 tested positive in 14/14 (100%) of recurrent CIN3 and 10/27 (37.0%) of recurrent CIN2. Combined HPV and/or methylation testing showed similar positivity rates as HPV and/or cytology. The CIN2/3 risk at 12 months posttreatment was 30.8% after a positive ASCL1/LHX8 result at 6 months posttreatment. Methylation levels of CIN2/3 in women with a persistent HPV infection were significantly higher compared with women with an incident or no HPV infection. In conclusion, posttreatment monitoring by methylation analysis of ASCL1/LHX8 and FAM19A4/miR124-2 showed a good performance for the detection of recurrent CIN. DNA methylation testing can help to identify women with recurrent CIN that require re-treatment.
Dual energy contrast enhanced breast imaging optimization using contrast to noise ratio (2007)

The properties of dual energy contrast enhanced breast imaging have been analyzed by imaging a 4 cm breast equivalent phantom consisting of adipose and glandular equivalent plastics. This phantom had superimposed another thin plastic which incorporated a 2 mm deep cylinder filled with iodinated contrast media. The iodine projected thicknesses used for this study was 3 mg/cm<sup>2</sup>. Low and high energy spectra that straddle the iodine K-edge were used. Critical parameters such as the energy spectra and exposure are discussed, along with post processing by means of nonlinear energy dependent function. The dual energy image was evaluated using the relative contrast to noise ratio of a 2.5 mm x 2.5 mm region of the image at the different iodine concentrations incorporating different breast composition with respect to the noniodinated areas. Optimum results were achieved when the low and high-energy images were used in such a way that relative contrast to noise ratio of the iodine with respect to the background tissue was maximum. A figure of merit suggests that higher noise levels can be tolerated at the benefit of lower exposure. Contrast media kinetics of a phantom incorporating a water flow of 20.4 ml/min through the plastic cylinder suggests that time domain imaging could be performed with this approach. The results suggest that optimization of dual energy contrast enhanced mammography has the potential to lead to the development of perfusion digital mammography.
Circulating Tumor DNA as an Early Indicator of Response to T-cell Transfer Immunotherapy in Metastatic Melanoma (2016)

We show that the dynamic changes occurring in BRAF V600E ctDNA levels within the first month following T-cell transfer immunotherapy in metastatic melanoma can be used to rapidly identify responding from nonresponding patients, potentially allowing clinicians to make critical treatment-related decisions in a more timely manner. These data also suggest that the majority of tumor killing by TIL occurs very early after the initiation of therapy. Clin Cancer Res; 22(22); 5480-6. ©2016 AACR.
Identification of genes encoding N‐glycan processing β‐N‐acetylglucosaminidases in Trichoplusia ni and Bombyx mori: Implications for glycoengineering of baculovirus expression systems (2009)

Glycoproteins produced by non-engineered insects or insect cell lines characteristically bear truncated, paucimannose N-glycans in place of the complex N-glycans produced by mammalian cells. A key reason for this difference is the presence of a highly specific N-glycan processing beta-N-acetylglucosaminidase in insect, but not in mammalian systems. Thus, reducing or abolishing this enzyme could enhance the ability of glycoengineered insects or insect cell lines to produce complex N-glycans. Of the three insect species routinely used for recombinant glycoprotein production, the processing beta-N-acetylglucosaminidase gene has been isolated only from Spodoptera frugiperda. Thus, the purpose of this study was to isolate and characterize the genes encoding this important processing enzyme from the other two species, Bombyx mori and Trichoplusia ni. Bioinformatic analyses of putative processing beta-N-acetylglucosaminidase genes isolated from these two species indicated that each encoded a product that was, indeed, more similar to processing beta-N-acetylglucosaminidases than degradative or chitinolytic beta-N-acetylglucosaminidases. In addition, over-expression of each of these genes induced an enzyme activity with the substrate specificity characteristic of processing, but not degradative or chitinolytic enzymes. Together, these results demonstrated that the processing beta-N-acetylglucosaminidase genes had been successfully isolated from Trichoplusia ni and Bombyx mori. The identification of these genes has the potential to facilitate further glycoengineering of baculovirus-insect cell expression systems for the production of glycosylated proteins.
IMAGING THE EARLY UNIVERSE WITH THE BOOMERANG EXPERIMENT (2003)

The BOOMERanG experiment has recently detected temperature fluctuations the Cosmic Microwave Background (CMB), the otherwise isotropic radiation coming from the early Universe. These anisotropies have a low contrast (about 30 ppm) and feature a peculiar angular power spectrum at angles corresponding to sub-horizon scales at recombination. In the current cosmological model, these structures result from acoustic oscillations in the primeval plasma. In the framework of the Hot Big Bang theory with the inflationary hypothesis, the statistical properties of the image of the CMB allow us to measure most of the cosmological parameters.
IMU dataset for motion and device mode classification (2017)

Classification of motion mode (walking, running, standing still) and device mode (hand-held, in pocket, in backpack) is an enabler in personal navigation systems for the purpose of saving energy and design parameter settings and also for its own sake. Our main contribution is to publish one of the most extensive datasets for this problem, including inertial data from eight users, each one performing three pre-defined trajectories carrying four smartphones and seventeen inertial measurement units on the body. All kind of metadata is available such as the ground truth of all modes and position. A second contribution is the first study on a joint classifier of motion and device mode, respectively, where preliminary but promising results are presented.
Infrared transmission at the 3.39 µm helium-neon laser wavelength in liquid-core quartz fibers (1979)

Measurement of optical transmission loss at the 3.39 μm line of an He-Ne laser in a tetrachloroethylene (C <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> Cl <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</inf> )-filled fused-quartz fiber is reported. The loss is found to be 56 dB/km at this wavelength.
Association of a Sodium Channel α Subunit Promoter Variant with Blood Pressure (2002)

The SCNNIA gene, which is located on human chromosome 12p13.3, encodes the alpha subunit of the amiloride-sensitive epithelial sodium channel, and mutations in SCNNIA can result in pseudohypoaldosteronism type I. It was postulated that genetic variations in SCNN1A could lead to an increased risk of hypertension. Sequence variations in SCNN1A were identified, and the association between these polymorphisms and BP was examined in a large cohort (n = 3898) representing the general population in Japan. Four polymorphisms in the promoter region, three polymorphisms in the exonic region, and one polymorphism in the first intron were identified. Because association studies with one-half of the study population indicated that the A(2139)G polymorphism, among others, significantly affected BP, this polymorphism was studied in the entire study population. Multiple logistic analyses indicated that the odds ratio for hypertension with the GA+GG genotype was 1.31 (P = 0.0154) in the total population and 1.77 (P = 0.0035) among subjects <60 yr of age. A significantly higher frequency of proteinuria was also observed among subjects with the GA+GG genotype. A transient transfection assay using MDCK cells indicated that the promoter activity of the G(2139) allele was higher than that of the A(2139) allele. Therefore, possession of the SCNN1A G(2139) allele significantly increased the risk of hypertension. A lower level of SCNN1A subunit expression among subjects with the AA genotype might lead to lower levels of sodium reabsorption in the kidney and might provide protection against the development of hypertension.
Ethane (2007)

This paper presents Ethane, a new network architecture for the enterprise. Ethane allows managers to define a single network-wide fine-grain policy, and then enforces it directly. Ethane couples extremely simple flow-based Ethernet switches with a centralized controller that manages the admittance and routing of flows. While radical, this design is backwards-compatible with existing hosts and switches.
Deformable Spectrograms (2005)

Speech and other natural sounds show high temporal correlation and smooth spectral evolution  punctuated by a few, irregular and abrupt changes. In a conventional Hidden Markov Model (HMM), such structure is represented weakly and indirectly through transitions between explicit states representing ‘steps’ along such smooth changes. It would be more efﬁcient and informative to model successive spectra as transformations of their immediate predecessors, capturing the evolution of the signal energy through time. We present a model which focuses on local deformations of adjacent bins in a time-frequency surface to explain an observed sound, using explicit representation only for those bins that cannot be predicted from their context. We further decompose the log-spectrum into two additive layers, which are able to separately explain and model the evolution of the harmonic excitation, and formant ﬁltering of speech and similar sounds. Smooth deformations are modeled with hidden transformation variables in both layers, using Markov Random ﬁelds (MRFs) with overlapping subwindows as observations; inference is efﬁciently performed via loopy belief propagation. The model can ﬁll-in deleted time-frequency cells without any signal model, and an entire signal can be compactly represented with a few speciﬁc states along with the deformation maps for both layers. We present results on a speech recognition task, that suggest that the model discovers a global structure on the dynamics of the signal’s energy that helps to alleviate the problems generated by noise interferences.
Establishment and characterization of a new human synovial sarcoma cell line, HS-SY-II. (1992)

This HS-SY-II cell line retaining the distinct morphological characteristics as the monophasic spindle cell type of synovial sarcoma therefore will be extremely useful for various pathomorphologic investigations on synovial sarcoma.
Micro Projects (2017)

Computer systems courses are often challenging to students who must learn the characteristics and behavior of a variety of system components and tools across multiple levels of abstraction. This workshop shows how microcontroller-based projects ("micro projects") can make topics such as data/program representation, bit-manipulation, I/O operation, event-handling, and digital communication more visible, concrete, and motivating. Participants will learn to use a low-cost hardware platform (programming in C/C++) to develop two example micro projects that demonstrate bit manipulation using digital I/O, and event handling with interrupts. We discuss how these projects may be extended or modified to introduce other topics, including microcontroller ISA, assembly language programming, and stack operation. Other project examples will be presented that use serial communication, timers, and a simple multitasking executive to illustrate program/data representation, digital communication, optimization, and operating system principles. We will discuss ways micro projects can be integrated into systems courses at various levels of the curriculum (by varying scaffolding) or used as a framework for an embedded systems/physical computing course. In addition to handouts, we supply participants with the software and hardware for use during the workshop and sources for acquiring them for future classroom use.
Analysis of anthocyanins in red onion using capillary electrophoresis‐time of flight‐mass spectrometry (2008)

For the first time, a capillary electrophoresis-time of flight-mass spectrometry analysis method for detecting anthocyanins in red onion was developed. The analysis method included the use of silica capillaries coated with poly-LA 313 (polycationic amine-containing polymer) and an MS-compatible volatile background electrolyte (BGE). The method was environmentally friendly and sensitive; and its rapidness combined with an acidic BGE helped in preventing anthocyanin degradation. By using high-resolution TOF-MS with pre-run tuning of masses, low mass errors were achieved in the determination of conjugated anthocyanins in red onion, and a simultaneous up-front fragmentation provided confirmation of the aglycon backbone for their secure identification. Most anthocyanins (at least seven out of ten) known in red onion from the literature were found, as well as one new for this matrix.
Bone changes after short-term whole body vibration are confined to cancellous bone. (2018)

The benefits of vibration therapy over five weeks were confined to cancellous bone.
Synthesis of oligopeptides as polynucleotide analogs. (1995)

Several dipeptides which have a nucleic acid base in their side chains were designed as water-soluble nucleotide analogs. Amino acids having a uracil or adenine moiety in the gamma-position were synthesized and were connected with another amino acid (spacer) to afford dipeptides. The oligopeptides were prepared from the dipeptides as monomer units. Although all the oligopeptides having uracil moieties examined were water-soluble as expected, these exhibited no hypochromic effect with poly A or poly dA. Contrary, the oligopeptides with adenines exhibited large hypochromicity (ca. 30%) base-specifically with poly dT or poly U.
Association of Mycoplasma penetrans with Human Immunodeficiency Virus Infection (1995)

A cross-sectional study was done to determine the seroprevalence of Mycoplasma penetrans in human immunodeficiency virus (HIV) type 1-seropositive and -seronegative persons recruited in France. The data were analyzed with respect to the sociodemographic, clinical, and biologic status of the patients. M. penetrans seropositivity was associated with HIV infection (18.2% of HIV-seropositive vs. 1.3% of HIV-seronegative persons were M. penetrans-seropositive; P < .001). M. penetrans infection was predominantly but not exclusively associated with homosexual practices in HIV-seropositive subjects and thus presumably sexually transmitted. M. penetrans seroprevalence increased with progression of HIV-associated disease. No association was found between M. penetrans and Kaposi's sarcoma. Thus, there is an unambiguous association between M. penetrans and HIV, particularly among homosexual persons, but its clinical significance remains to be investigated.
Protein secretion in Tetrahymena thermophila: Characterization of the secretory mutant strain sb281 (1985)

The ciliated protozoon Tetrahymena thermophila contains membrane-bounded secretory organelles termed mucocysts, the release of which has previously been characterized ultrastructurally as a model system for the events occurring during membrane fusion and protein secretion. Recently, a series of secretory mutant strains of Tetrahymena has been isolated following mutagenesis of a parental wild-type strain designated SB210. In this study, the correlates of non-release in one unique mutant strain of this series, designated SB281, are described. SB281 appears to express a diminished (undetectable) level of the major 34000 Mr proteinaceous secretory product of Tetrahymena, as determined by Western immunoblot analysis and indirect immunofluorescence labelling. Thin-section electron-microscopic studies of these cells reveal that they possess no docked or free mature mucocysts. In addition, freeze-fracture electron microscopy demonstrates that an intramembrane particle array termed the rosette, present in the plasma membrane of wild-type cells above sites of docked mucocysts, is absent in the plasma membrane of mutant SB281 cells. A morphometric analysis of intramembrane particles in the plasma membrane of both wild-type and mutant cells indicates that both strains have a similar intramembrane particle density in both leaflets of the the plasma membrane. Although assembled rosettes are missing in the plasma membrane of mutant cells, a 15 nm intramembrane particle size class does exist in the plasma membrane of the mutant, but this size class is significantly reduced in number relative to wild-type.