gebhart/patrepeval huggingface dataset:
Abstract 2649: Development of an antibody-drug conjugate targeting TIM-1 for the treatment of ovarian and renal cell carcinoma (2014)

Abstract T cell immunoglobulin and mucin domain 1 (TIM-1) is a type I transmembrane protein that was originally described as kidney injury molecule 1 (KIM-1) due to its elevated expression in kidney and urine after renal injury. Tim-1 expression is also upregulated in several human cancers, most notably in renal cell and ovarian carcinomas, but has very restricted expression in healthy tissues thus representing a promising target for antibody mediated therapy. To this end we have developed a fully human monoclonal IgG1 antibody specific for extracellular domain of TIM-1. This antibody was shown to bind purified recombinant chimeric TIM-1-Fc protein and TIM-1 expressed on a variety of transformed cell lines, including Caki-1 (human renal clear cell carcinoma), IGROV-1 (human ovarian adenocarcinoma) and ACHN (human renal cell adenocarcinoma). Internalization studies using confocal microscopy revealed the antibody was rapidly internalized by cells in vitro, and the internalization was confirmed by quantitative imaging flow cytometry using ImageStream. An antibody-drug conjugate (ADC) was produced with the anti-TIM-1 antibody covalently linked to a potent cytotoxin, monomethyl auristatin E (MMAE), and designated CDX-014. The ADC was shown to exhibit in vitro cytostatic or cytotoxic activity against a variety of TIM-1 expressing cell lines, but not on TIM-1 negative cell lines. Using the Caki-1 and IGROV-1 xenograft models, CDX-014 showed significant anti-tumor activity in the range of 75-300 μg/dose given every four days for a total of four doses. Activities are on-going to support the manufacturing and IND-enabling studies in order to advance CDX-014 towards clinical studies in renal cell carcinomas and potentially other TIM-1 expressing tumors. Citation Format: Lawrence J. Thomas, Laura Vitale, Thomas O'Neill, Ree Dolnick, Paul K. Wallace, Hans Minderman, Lauren E. Gergel, Eric M. Forsberg, James M. Boyer, James R. Storey, Russell A. Hammond, Jennifer Widger, Karuna Sundarapandiyan, Andrea Crocker, Henry C. Marsh, Tibor Keler. Development of an antibody-drug conjugate targeting TIM-1 for the treatment of ovarian and renal cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2649. doi:10.1158/1538-7445.AM2014-2649
Subtype cross-reactive, infection-enhancing antibody responses to influenza A viruses (1994)

Antibody-dependent enhancement of the uptake of influenza A virus by Fc receptor-bearing cells was analyzed by using virus strains of the three human influenza A virus subtypes, A/PR/8/34 (H1N1), A/Japan/305/57 (H2N2), and A/Port Chalmers/1/73 (H3N2). Immune sera obtained from mice following primary infection with an H1N1, H2N2, or H3N2 subtype virus neutralized only virus of the same subtype; however, immune sera augmented the uptake of virus across subtypes. Immune sera from H1N1-infected mice augmented uptake of the homologous (H1N1) and H2N2 viruses. Antisera to the H2N2 virus augmented the uptake of virus of all subtypes (H1N1, H2N2, or H3N2). Antisera to the H3N2 virus augmented the uptake of the homologous (H3N2) and H2N2 viruses. These results show that subtype cross-reactive, nonneutralizing antibodies augment the uptake of influenza A virus strains of different subtypes. Antibodies to neuraminidase may contribute to the enhanced uptake of viruses of a different subtype, because N2-specific monoclonal antibodies augmented the uptake of both A/Japan/305/57 (H2N2) and A/Port Chalmers/1/73 (H3N2) viruses.
Low temperature SiCN as dielectric for hybrid bonding (2023)

For various 3D integration schemes, such as Collective Die to wafer stacking (CoD2W) and Die to wafer (D2W) bonding, the thermal budget needs to be well below 250°C due to the presence of temporary bonding materials. In this paper we, present a new PECVD SiCN layer deposited at 175°C, optimized for hybrid bonding applications. The layer provides void-free wafer to wafer bonding interface demonstrated by high bond strength even at a post bond annealing (PBA) temperature of 200°C and devoid of any outgassing voids until 350°C. Additionally, it has been verified that the layer has excellent moisture and as electrical barrier properties.
Performance Analysis of GALS Datalink Based on Pausible Clocking (2012)

In this paper we present the performance analysis of point-to-point GALS data links based on pausible clocking. The average synchronization latency and data throughput in the burst-mode communication are analytically addressed, taking the I/O port interconnect delay and the clock-tree propagation delay into account. The upper bounds for the throughput-tolerant clock tree and interconnect delays are derived. As an example, based on the pausible clocking scheme, a GALS OFDM base band transmitter, named Moon rake, was designed. Comprehensive simulations were carried out to evaluate and optimize the performance of GALS system with regards to different I/O port behaviors as well as interconnect and clock-tree delays.
ChemInform Abstract: An MNDO Study of Planar Thioacyl‐Substituted Carbocations (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Simplified Flip-Flop Gate Model for EEMI Injection (2019)

We present a second order dynamical system to represent the behavior of a D flip-flop. We employ windowing functions and vector fields to replicate a characteristic found in [1], which resorts to switching. The model also takes into account metastable behavior, which can be exploited when studying software execution faults due to an undefined logical state. We conceived the noise injection to be additive noise targeting the transition between the stable equilibrium points. However, the model is flexible and many parameters can be changed to alter its behavior.
Preparation of Nanohybrid Solid-State Electrolytes with Liquidlike Mobilities by Solidifying Ionic Liquids with Silica Particles (2007)

The novel ion-conducting properties of nanohybrid materials consisting of ionic liquids and nanosized silica were investigated. The nanohybrid materials can be prepared by a simple mechanical milling process, and their compositions can be controlled over a wide range of ratios of ionic liquid to nanosized silica particles. Interestingly, the hybrid materials remain in the solid state even when as much as 90 wt % of the ionic liquid is incorporated in the matrix, provided that nanosized silica with a particle size of 7 nm is used. The hybrid materials exhibit large conductivities from room temperature to the intermediate temperature region. For example, the conductivity of a [BMIm][TFSI]/silica (7 nm) hybrid containing 60 wt % ionic liquid increased to 1 × 10-2 S cm-1 at 300 °C, although the solid hybrids were stable even at the intermediate temperatures. The nanosize confinement of liquid molecules within the silica particles is presumed to be responsible for the liquidlike conductivities in the solid phase and for the stability of the ionic liquids to fluidity and evaporation. Nanosize effects of the ionic liquid on the conducting properties were also demonstrated.
Figure S4 from RAS–MAPK Reactivation Facilitates Acquired Resistance in <i>FGFR1</i>-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR–MEK Blockade (2023)

&lt;p&gt;Figure S4 shows immunoblots of cells expressing a subset of resistance ORFs&lt;/p&gt;
Flier: Flow-level congestion-aware routing for direct-connect data centers (2017)

Various topologies have been proposed in the context of high-performance computing and data center networking. Direct-connect topologies generally offer large capacity with high path diversity and are highly cost effective for general data center traffic patterns. However, the lack of simple yet efficient load balancing techniques for direct-connect fabrics has hindered these networks from gaining traction in data centers. This paper presents the design, implementation, and evaluation of Flicr, a light-weight host-based load balancing mechanism for direct-connect data centers. Flicr dynamically reroutes traffic through minimal and non-minimal routes to avoid congesting the fabric. This enables Flicr to efficiently minimize networking resource consumption while exploiting high path diversity in direct-connect fabrics to balance the network and gracefully handle link failures. Flicr requires only a simple kernel modification and is readily deployable in commodity data centers today. Our evaluations show that Flicr consistently outperforms other state-of-the-art load balancing designs, achieving 25-60% lower average flow completion time compared to adaptive routing. Flicr is also more robust against link failures and has 5-8 χ better performance relative to other schemes in the presence of link failures.
Femtosecond Writing of Tilted Fiber Bragg Gratings Through the Coating with a Phase Mask (2019)

Tilted fiber Bragg gratings are inscribed in nonphotosensitized single mode fibers through the polyimide coating using a femtosecond infrared laser and a phase mask, by translating the focusing lens and the fiber in orthogonal directions.
33 BMP-based Therapeutics and the BMP Signaling Pathways (2008)

The bone morphogenetic proteins (BMPs) were originally identified as molecules responsible for the bone-inductive activity present within bone matrix (Wozney et al. 1988). Now known to be a family of proteins within the larger transforming growth factor-β (TGF-β) family, the BMPs have a wide range of activities on various cell types (see Chapter 5). As discussed elsewhere in this volume, the BMP signaling system parallels, but is distinct from, that of TGF-β. BMP signaling is tightly controlled by a range of extracellular, intracellular, and nuclear modulators, suggesting many targets for pharmaceutical intervention. In this chapter, we discuss some of the potential therapeutic applications of the BMPs and locations in the BMP pathway that may lend themselves to development of therapeutics. Depending on the biology of the BMP, stimulation of the pathway, for example, by supplying exogenous ligand or by increasing endogenous expression, may provide a therapeutic; alternatively, suppression of the pathway via inhibition may be the desired therapeutic approach. In the latter part of the chapter, we give two examples of development of pharmaceuticals. In one case, the therapeutic is the BMP ligand itself; in the other, an inhibitor of the ligand is being evaluated. POTENTIAL THERAPEUTIC APPLICATIONS OF THE BMPS The BMPs are a family of growth and differentiation factors, some of which are expressed in almost every cell type. They have autocrine, paracrine, and perhaps even endocrine functions. Most are believed to be locally acting factors, but some circulate and have been reported to have systemic activities. The...
Longitudinal and circumferential strain assesment of left and right ventricles in acute myocardial infarction superimposed with microemboli (2014)

Background Microvascular obstruction is a major problem after reperfusion therapy of AMI. A recent study reported that longitudinal and circumferential strain after reperfusion therapy is an excellent predictor of left ventricular (LV) dysfunction in patients with anterior wall AMI [1,2]. In the current MRI investigation, we adapted a method routinely used in echocardiography for measuring LV, RV interventricular walls longitudinal strain [3]. Furthermore, we developed a well-controlled AMI superimposed with microemboli model to study LV and RV strain changes and compared it with animals subjected to LAD microembolization or occlusion/reperfusion.
Data from Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics (2023)

&lt;div&gt;Abstract&lt;p&gt;Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) results in complete regression of advanced cancer in some patients, but the efficacy of this potentially curative therapy may be limited by poor persistence of TIL after adoptive transfer. Pharmacologic inhibition of the serine/threonine kinase Akt has recently been shown to promote immunologic memory in virus-specific murine models, but whether this approach enhances features of memory (e.g., long-term persistence) in TIL that are characteristically exhausted and senescent is not established. Here, we show that pharmacologic inhibition of Akt enables expansion of TIL with the transcriptional, metabolic, and functional properties characteristic of memory T cells. Consequently, Akt inhibition results in enhanced persistence of TIL after adoptive transfer into an immunodeficient animal model and augments antitumor immunity of CD8 T cells in a mouse model of cell-based immunotherapy. Pharmacologic inhibition of Akt represents a novel immunometabolomic approach to enhance the persistence of antitumor T cells and improve the efficacy of cell-based immunotherapy for metastatic cancer. &lt;i&gt;Cancer Res; 75(2); 296–305. ©2014 AACR.&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Calling All Phones: From a Single-Chip Mobile Communicator to the Smart Phone of the Future (2012)

Generally seen as an innovative educational toy, the Speak & Spell played a critical role in the introduction of cost effective and power-efficient voice digitization. Speak & Spell was one of the earliest handheld, battery operated consumer devices having a keyboard and display and produced audio from digitally synthesized sound stored in replaceable cartridge ROM and played through a special digital signal processing clip. Such a technology stood as a precursor to digital voice transmission and ultimately spurred the exponential growth of digital cellular by influencing subsequent technological innovations and trends.
Experimental verification of higher-order mode suppression in a bent large-mode-area multi-cladding fiber (2010)

A novel technique to suppress the higher-order mode in a bent large-mode-area triple-cladding fiber is experimentally presented. 3-dB suppression of LP02 mode is observed on a fabricated triple-cladding fiber with 130-mm diameter bend.
Slip gain estimation in field orientation controlled induction machines using the system transient response (2005)

Field oriented control of induction machines is well-established and widely used in applications where high-bandwidth torque control of AC machines is needed. A key parameter in the implementation of indirect field orientation (IFO) is the slip gain (inverse of the rotor time constant), which is used to estimate the rotor flux angle. A new method for estimating the slip gain is presented in this paper. The method uses the transient response of the stator voltages following a change torque for these purposes. The method is independent of any machine or system parameter, and it can be easily integrated into standard drives and used in many industrial applications.
1.8-μm thulium microlasers integrated on silicon (2016)

A key challenge for silicon photonic systems is the development of compact on-chip light sources. Thulium-doped fiber and waveguide lasers have recently generated interest for their highly efficient emission around 1.8 &mu;m, a wavelength range also of growing interest to silicon-chip based systems. Here, we report on highly compact and low-threshold thulium-doped microcavity lasers integrated with silicon-compatible silicon nitride bus waveguides. The 200-&mu;mdiameter thulium microlasers are enabled by a novel high quality-factor (Q-factor) design, which includes two silicon nitride layers and a silicon dioxide trench filled with thulium-doped aluminum oxide. Similar, passive (undoped) microcavity structures exhibit Q-factors as high as 5.7 &times; 10<sup>5</sup> at 1550 nm. We show lasing around 1.8–1.9 &mu;m in aluminum oxide microcavities doped with 2.5 &times; 1020 cm<sup>−3</sup> thulium concentration and under resonant pumping around 1.6 &mu;m. At optimized microcavity-waveguide gap, we observe laser thresholds as low as 773 &mu;W and slope efficiencies as high as 23.5%. The entire fabrication process, including back-end deposition of the gain medium, is silicon-compatible and allows for co-integration with other silicon-based photonic devices for applications such as communications and sensing.
Nanoformulated water-soluble paclitaxel to enhance drug efficacy and reduce hemolysis side effect (2017)

Surgery, chemotherapy, and radiotherapy are the three top cancer treatment modalities. Paclitaxel (PTX) is one of the most widely used chemotherapy drugs. However, its clinical applications have been significantly limited due to: (i) serious hemolysis effect of currently available commercial paclitaxel formulations and (ii) its water insolubility. An easy way to deliver paclitaxel by a new nanocarrier system using pluronic copolymers of P123/F68 and Sorbitan monopalmitate (Span 40) was reported in our previous research article. The characterization of the formulation and analysis of drug release and cellular uptake were also presented. In this article, we reported discoveries of our follow-up in vivo antitumor and in vitro hemolytic study discoveries. The experimental results showed that the nanoformulated PTX achieved much better tumor suppression performance while reducing hemolysis side effects. This newly formulated drug can significantly improve patient outcomes in cancer chemotherapy.
Utilisation des complexes butadiene fer tricarbonyle pour l'etude du controle stereochimique a longue distance dans les molecules de type macrolide (1990)

Diabetes in pregnancy, whether the woman had diabetes prior to becoming pregnant or developed gestational diabetes, is associated with many complications and risks. In the first trimester, organogenesis can be disrupted by complications due to poor control of the mother's diabetes, leading to fetal malformations or perinatal mortality. Problems with glucose control in the remainder of the pregnancy can also have consequences for the child. These include macrosomia, shoulder dystocia, pre-eclampsia, hypoglycemia and an increased risk for obesity and diabetes in the future. Therefore, aggressive and prompt treatment of the high blood sugar levels, which cause these complications, is necessary. This review looks at the current treatments for pregnancies complicated by diabetes and evaluates the place of new and possible future treatments including diet, exercise, insulin, insulin analogs and oral and inhaled agents.
Abstract PR09: Cellular heterogeneity of ovarian carcinoma cells and its impact on tumor behavior (2013)

Abstract One of the most challenging aspects of cancer treatment is intratumoral heterogeneity (ITH). However it is been extremely difficult to monitor the extent to which individual clonal populations contribute to and affect tumor behavior because of the inability to culture tumor cells from patients in vitro without clonal selection under standard culture conditions, which lead to a loss in initial heterogeneity. Using a medium developed by Dr. Tan Ince that allows primary tumor cells to undergo continuous population doublings with minimal, if any, selection for or against specific clones, we generated 80 clonal populations from a Clear Cell Carcinoma (CCC) patient sample and monitored the extent of phenotypic and genomic heterogeneity among 12 of the clonal populations. These clones showed striking heterogeneity in copy number alterations as well as morphologic and phenotypic heterogeneity in vitro in assays such as anoikis, growth in soft agar, population doubling time, and growth in 3D reconstituted basement membrane cultures. To examine correlations between in vitro properties and tumor formation in vivo, we tagged the clones with Gaussia-Luciferase (Gluc), a secreted luciferase, which allowed us to monitor tumor burden over time using a blood-based assay. Based on tumor growth at 10 weeks, only two clonal populations were able to grow in the peritoneum when injected alone, one of which (#31) showed a much more rapid growth rate than the other; however #31 was still limited in its tumorigenic capacity, generating only ascitic tumor populations. To address whether functional crosstalk between clones affects tumor progression, we injected mixtures of the clones. Interestingly, mixtures of the 12 clones resulted in the generation of more aggressive in vivo phenotypes, e.g. the formation of solid peritoneal tumors and metastasis to lungs and brain, behaviors not detected with any individual clones. These results suggest that there is cooperativity between the clones to enhance growth and induce metastasis. The study has provided evidence that cell lines generated from individual clones vary significantly in their functional activities in vitro and in vivo. Moreover, by studying the single cell clones, we have found evidence for the existence of interclonal crosstalk during tumor progression and are currently studying the nature and impact of such cross talks on tumor progression and metastasis. This abstract is also presented as Poster A57. Citation Format: Suha Naffar-Abu Amara, Laura M. Selfors, Marit Krohn, Tan A. Ince, Bo R. Rueda, Rosemary Foster, Gordon B. Mills, Joan S. Brugge. Cellular heterogeneity of ovarian carcinoma cells and its impact on tumor behavior. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr PR09.
Jaw bone metastases: four cases. (2007)

In view of the resemblance in the presentation of metastases and other tumors affecting the jaws, a high index of clinical suspicion is advocated to ensure early, multidisciplinary care of hosts.
Polypropylene/polyethylene blends as models for high‐impact propylene‐ethylene copolymers, part 2: Relation between composition and mechanical performance (2013)

Abstract The relation between composition and mechanical performance of a series of binary polyolefin blends was studied in this article. A fractionation of these model compounds with temperature rising elution fractionation (TREF) was applied to study the possibility to fractionate industrially relevant heterophasic polyolefin systems. The separation quality according to molecular structures or chemical composition was found to be good for most of the systems, but especially the separation of ethylene‐propylene random copolymer and high density polyethylene by TREF turned out to be difficult if not impossible. An extensive mechanical characterisation including the determination of brittle‐to‐ductile transition curves showed significant effects of modifier type and amount. Toughness effects can be related primarily to the modulus differences between modifier and matrix. Compatibility and particle size only have a secondary influence, but must be considered for a detailed interpretation of the mechanics of the investigated systems. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013