gebhart/patrepeval huggingface dataset:
Grafting polymer from oxygen-vacancy-rich nanoparticles to enable protective layers for stable lithium metal anode (2020)

Fabricating an artificial solid electrolyte interface (SEI) is a promising approach to improve cycling stability of lithium metal batteries. In this work, a new category of artificial SEI based on oxygen vacancy-rich hybrid nanoparticles was prepared by covalently grafting polymers from yttria–stabilized zirconia (YSZ) nanoparticles via surface-initiated atom transfer radical polymerization (SI-ATRP). The hairy nanoparticles had high dispersibility in dimethylsulfoxide, and were solution casted into uniform thin films with high inorganic content, high ionic conductivity (>1 × 10−4 S/cm at r.t.), and good mechanical properties (Young's modulus 7.56 GPa). No dendrite formation was observed by in-situ optical microscopy on a lithium metal protected by such artificial SEI. Protected anodes were stably cycled at 3 mA/cm2 and 3 mA h/cm2 with low overpotentials (20 mV) for >2500 h. LiNi0.8Co0.15Al0.05O2 (NCA)|Li full cells with protected Li anode showed much higher specific discharge capacity at various rates and improved capacity retention compared to unprotected Li anode.
B Mode Imaging And Doppler Ultrasonic Catheters For Use With Fiber Optic Endoscopes (1988)

The musocal surface of the intestine may be inspected by physicians using flexible fiberoptic endoscopes. Ultrasound energy can be used with these endoscopes to interrogate beyond the surface of the intestine and acquire information about the wall and adjacent tissue. Combined ultrasonic and fiberoptic probes have been built for this purpose, but the combination of both modalities results in a complex endsocope. Alternatively, we have developed miniature ultrasonic probes that can be used as an accessory devices for standard endoscopes. Probes have been built to obtain either a cross sectional image of the wall or acquire blood flow information. Technical details of the probes, their fabrication, and representative results are given.
High‐Resolution Patterning of Molecular Glasses Using Supercritical Carbon Dioxide (2006)

A glass-forming molecule, consisting of hexa(hydroxyphenyl)benzene [HHPB] protected with six tert-butoxycarbonyl (t-Boc) groups, is patterned and developed to produce features as small as 50 nm (see Figure) using supercritical CO2 (scCO2). Protected HHPB was shown to be completely soluble in scCO2 without incorporation of either fluorine or silicon but could be rendered insoluble in scCO2 by acid-catalyzed removal of the solubilizing t-Boc groups.
Resolving the cosmological missing energy problem (1999)

Some form of missing energy may account for the difference between the observed cosmic matter density and the critical density. Two leading candidates are a cosmological constant and quintessence (a time-varying, inhomogeneous component with negative pressure). We show that an ideal, full-sky cosmic background anisotropy experiment may not be able to distinguish the two, even when non-linear effects due to gravitational lensing are included. Because of this ambiguity, microwave background experiments alone may not determine the matter density or Hubble constant very precisely. We further show that degeneracy may remain even after considering classical cosmological tests and measurements of large scale structure.
Evaluation of treatment effects in patients with endometrial cancer and POLE mutations: An individual patient data meta‐analysis (2021)

Ten percent of all endometrial cancers have mutations in the DNA repair gene DNA polymerase epsilon (POLE). Women who have endometrial cancers with true POLE mutations experience almost no recurrences or deaths from their cancer even when their tumors appear to have very unfavorable characteristics. Additional therapy (radiation and chemotherapy) does not appear to improve outcomes for women with POLE-mutated endometrial cancer, and this supports the move to less therapy and less associated toxicity. Diligent classification of endometrial cancers by molecular features provides valuable information to inform prognosis and to direct treatment/no treatment.
Dynamic flux balance analysis of the metabolism of Saccharomyces cerevisiae during the shift from fully respirative or respirofermentative metabolic states to anaerobiosis (2012)

Dynamic flux balance analysis was utilized to simulate the metabolic behaviour of initially fully respirative and respirofermentative steady-state cultures of Saccharomyces cerevisiae during sudden oxygen depletion. The hybrid model for the dynamic flux balance analysis included a stoichiometric genome-scale metabolic model as a static part and dynamic equations for the uptake of glucose and the cessation of respirative metabolism. The yeast consensus genome-scale metabolic model [Herrgård MJ et al. (2008) Nat Biotechnol 26, 1155-1160; Dobson PD et al. (2010) BMC Syst Biol 4, 145] was refined with respect to oxygen-dependent energy metabolism and further modified to reflect S. cerevisiae anabolism in the absence of oxygen. Dynamic flux balance analysis captured well the essential features of the dynamic metabolic behaviour of S. cerevisiae during adaptation to anaerobiosis. Modelling and simulation enabled the identification of short time-scale flux distribution dynamics under the transition to anaerobic metabolism, during which the specific growth rate was reduced, as well as longer time-scale process dynamics when the specific growth rate recovered. Expression of the metabolic genes was set into the context of the identified dynamics. Metabolic gene expression responses associated with the specific growth rate and with the cessation of respirative metabolism were distinguished.
Nanostructured composite materials from microfibrillated cellulose and carbon nanotubes (2009)

Thin composite films were prepared from the mixture of the aqueous suspension of microfibrillated cellulose (MFC) and multi-walled carbon nanotubes (MWCNTs). The morphology, electrical conductivity ...
Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-a]pyrazine Scaffold as a Novel Proline Mimetic (2013)

To develop novel inhibitor of apoptosis (IAP) proteins antagonists, we designed a bicyclic octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline bioisostere. This design was based on the X-ray co-crystal structure of four N-terminal amino acid residues (AVPI) of the second mitochondria-derived activator of caspase (Smac) with the X-chromosome-linked IAP (XIAP) protein. Lead optimization of this scaffold to improve oral absorption yielded compound 45, which showed potent cellular IAP1 (cIAP1 IC(50): 1.3 nM) and XIAP (IC(50): 200 nM) inhibitory activity, in addition to potent tumor growth inhibitory activity (GI(50): 1.8 nM) in MDA-MB-231 breast cancer cells. X-ray crystallographic analysis of compound 45 bound to XIAP and to cIAP1 was achieved, revealing the various key interactions that contribute to the higher cIAPI affinity of compound 45 over XIAP. Because of its potent IAP inhibitory activities, compound 45 (T-3256336) caused tumor regression in a MDA-MB-231 tumor xenograft model (T/C: -53% at 30 mg/kg).
Trihexyphenidyl as a possible therapeutic option in clozapine-induced nocturnal enuresis (1996)

Enuresis is an adverse event of clozapine treatment. The occurrence of nocturnal functional enuresis in two schizophrenic patients during the initial phase of clozapine therapy is reported. Beneficial effect of trihexyphenidyl administration (5 mg at 21.00 h) on clozapine-induced enuresis is clearly demonstrated in one patient. Trihexyphenidyl discontinuation and subsequent readministration in this patient led to corresponding recurrence and then disappearance of enuresis. Involvement of the cholinergic system has been proposed as one of the possible pathophysiological mechanisms of clozapine-induced enuresis.
Make or buy analysis for rapid manufacturing (2007)

Purpose The purpose of this paper is to outline how rapid manufacturing (RM) could influence the decision‐making process for managers involved in make or buy decisions. Design/methodology/approach A literature review on make or buy issues has been carried out and the results of which have been distilled into a number of qualitative considerations. These considerations have been formed into three possible make or buy scenarios: the firm has no experience of rapid prototyping (RP) or RM; the firm already has an RP department; and the firm already has an RM function. In order to analyse the decision further a quantitative approach has been taken, mainly adapted to the last scenario but applicable also to the second scenario. Here, manufacturing cost data has been directly compared with price information from two current RP bureaus. The differences between RM cost and RP price have been studied. Findings Strategically, the points analysed were in favour of the make option. Economically, the lack of dedicated RM bureaus and the consequent use of RP costing has further pushed the make or buy decision in favour of make. Originality/value There is a lack of work on the implementation of RM as a mainstream manufacturing process. Existing knowledge has begun to look at the use and costs of RM, however, this paper highlights the lack of dedicated RM providers.
Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes (2013)

The hallmark of periodontal disease is the progressive destruction of gingival soft tissue and alveolar bone, which is initiated by inflammation in response to an invasive and persistent bacterial insult. In recent years, it has become apparent that this tissue destruction is associated with a decrease in local regulatory processes, including a decrease of forkhead box P3-expressing regulatory lymphocytes. Accordingly, we developed a controlled release system capable of generating a steady release of a known chemoattractant for regulatory lymphocytes, C-C motif chemokine ligand 22 (CCL22), composed of a degradable polymer with a proven track record of clinical translation, poly(lactic-co-glycolic) acid. We have previously shown that this sustained presentation of CCL22 from a point source effectively recruits regulatory T cells (Tregs) to the site of injection. Following administration of the Treg-recruiting formulation to the gingivae in murine experimental periodontitis, we observed increases in hallmark Treg-associated anti-inflammatory molecules, a decrease of proinflammatory cytokines, and a marked reduction in alveolar bone resorption. Furthermore, application of the Treg-recruiting formulation (fabricated with human CCL22) in ligature-induced periodontitis in beagle dogs leads to reduced clinical measures of inflammation and less alveolar bone loss under severe inflammatory conditions in the presence of a diverse periodontopathogen milieu.
Mini-pterional approach for clip ligation of ethmoidal dural arteriovenous fistula (2019)

Ethmoidal dural arteriovenous fistulas (DAVFs) have a near-universal association with cortical venous drainage and a malignant clinical course. Endovascular treatment options are often limited due to the high frequency of ophthalmic artery ethmoidal supply. A 64-year-old gentleman presented with syncope and was found to have a right ethmoidal DAVF. Rather than the traditional bicoronal craniotomy, an endoscope-assisted mini-pterional approach for clip ligation is demonstrated. The mini-pterional craniotomy allows a minimally invasive approach to ethmoidal DAVF via a lateral trajectory. The endoscope can help achieve full visualization in the narrow corridor.The video can be found here: https://youtu.be/ZroXp-T35DI.
A general approach for hysteresis-free, operationally stable metal halide perovskite field-effect transistors (2020)

Despite sustained research, application of lead halide perovskites in field-effect transistors (FETs) has substantial concerns in terms of operational instabilities and hysteresis effects which are linked to its ionic nature. Here, we investigate the mechanism behind these instabilities and demonstrate an effective route to suppress them to realize high-performance perovskite FETs with low hysteresis, high threshold voltage stability (ΔV<sub>t</sub> < 2 V over 10 hours of continuous operation), and high mobility values >1 cm<sup>2</sup>/V·s at room temperature. We show that multiple cation incorporation using strain-relieving cations like Cs and cations such as Rb, which act as passivation/crystallization modifying agents, is an effective strategy for reducing vacancy concentration and ion migration in perovskite FETs. Furthermore, we demonstrate that treatment of perovskite films with positive azeotrope solvents that act as Lewis bases (acids) enables a further reduction in defect density and substantial improvement in performance and stability of n-type (p-type) perovskite devices.
Response to "Mutations of the NOGGIN and of the activin A type I receptor genes in fibrodysplasia ossificans progressiva (FOP)" by Lucotte et al. (2008)

Gender dynamics affect the amount of time that CTAs spend with villagers during drug distribution, and the relative amount of speech when both genders work together. Both genders are not meeting expectations for trachoma prevention education and greeting villagers, and novel training methods are necessary.
Post fabrication annealing effects on electrical and optical characteristics of n-ZnO nanorods/p-Si heterojunction diodes (2011)

Annealing effects on optical and electrical properties of n-ZnO/p-Si heterojunction diodes are studied. ZnO nanorods are grown on p-Si substrate by aquous chemical growth technique. As grown sample ...
Quenching of Quantum Dot Emission by Fluorescent Gold Clusters: What It Does and Does Not Share with the Förster Formalism (2013)

Understanding the interactions that control the energy transfer between dyes, or luminescent quantum dots (QDs), and gold nanoparticles still has several unanswered questions. In this study we probed these interactions using a unique model where CdSe-ZnS QDs were coupled to fluorescent gold nanoclusters (AuNCs). Steady-state and time-resolved fluorescence measurements were used to investigate the effects of spectral overlap and separation distance on the quenching of QD photoemission in these assemblies, using three different size QDs with distinct emission spectra and a variable length polyethylene glycol bridge. We found that the QD photoluminescence quenching efficiency depends on the spectral overlap and separation distance, with larger quenching efficiencies than what would be expected for a QD-dye pair with similar overlap. Moreover, despite the large losses in QD PL, we found no resonance enhancement in the cluster emission for any of the sample configurations used. These results indicate that the mechanism driving the quenching by metal clusters shares an important feature (namely dependence on the spectral overlap) with the Förster dipole–dipole coupling at the heart of fluorescence resonance energy transfer (FRET) and widely validated for dye-dye and QD-dye assemblies. They also prove that the energy losses induced by metal nanostructures are governed by a process that is different from the Förster mechanism.
Measuring Bird Migration Using Spatial and Temporal Counts (2001)

12 pages, 1 article
Papers Presented at the Annual Meetings of the Hip Society (2007)

The 2007 Hip Society Symposium is the end product of papers presented at the 2006 Closed Fall Meeting in Iowa City, Iowa, and the 2007 Open Meeting of the Hip Society held in San Diego, California. These exceptional programs were well planned and organized by John C. Callaghan, MD and Doug Dennis, MD. Symposia topics include a variety of different aspects of hip surgery including basic science, biomechanics, computer navigation, venous thromboembolism prophylaxis, hip dislocation, and a large number of clinical and retrieval followup reports regarding the cross-linked polyethylenes and ceramic-on-ceramic bearing surfaces. Revision topics include both the acetabulum and femur. One of the most interesting aspects that emerged from the Closed Meeting was the juxtaposition of the different perspectives on hip resurfacing procedures and the long-term clinical success of 2nd generation uncemented femoral components using a variety of different designs in both young and elderly patients. The excellent success of these 2nd generation uncemented femoral components when coupled with modern bearing surfaces should set a comparative standard for alternative approaches, such as the resurfacing arthroplasty. Direct comparative studies of current uncemented hip replacements as compared to hip resurfacing procedures are needed. As we look forward to continued progress in the area of hip surgery, it is always interesting to remember and review historical information archived in the orthopaedic literature. The classic articles included in this symposium are a pair of articles that were published together more than 60 years ago. These authors described a group of patients with severe limitation of hip motion associated with intrapelvic protrusion of the femoral head and acetabular fossa known as arthrokatadysis or the “Otto pelvis.” This entity is only rarely encountered in the modern era, most likely due to earlier surgical intervention, but arthrokatadysis is important to recognize due to the difficulties associated with surgical dislocation and subsequent restoration of the femoral head center during acetabular reconstruction. Finally, I would like to sincerely thank the reviewers and the editorial staff for their expertise, diligence, and important contributions toward the preparation of this annual symposium of the Hip Society. Arlen D. Hanssen, MD Department of Orthopaedics, Mayo Clinic, Rochester, MN; and, Deputy Editor of the Hip Society, Clinical Orthopaedics and Related Research, Philadelphia, PA
Comparisons Of An Adaptive Neural Network Based Controller And An Optimized Conventional Power System Stabilizer (2007)

Power system stabilizers are widely used to damp out the low frequency oscillations in power systems. In power system control literature, there is a lack of stability analysis for proposed controller designs. This paper proposes a Neural Network (NN) based stabilizing controller design based on a sixth order single machine infinite bus power system model. The NN is used to compensate the complex nonlinear dynamics of power system. To speed up the learning process, an adaptive signal is introduced to the NN's weights updating rule. The NN can be directly used online without offline training process. Magnitude constraint of the activators is modeled as saturation nonlinearities and is included in the stability analysis. The proposed controller design is compared with Conventional Power System Stabilizers whose parameters are optimized by Particle Swarm Optimization. Simulation results demonstrate the effectiveness of the proposed controller design.
On the Modeling and Analysis of Fast Conditional Handover for 5G-Advanced (2022)

Conditional handover (CHO) is a state-of-the-art 3GPP handover mechanism used in 5G networks. Although it improves mobility robustness by reducing mobility failures, the decoupling of the handover preparation and execution phases in CHO significantly increases the signaling overhead. For 5G-Advanced networks, fast CHO (FCHO) is a recent 3GPP proposal that offers a practical solution whereby the user equipment (UE) can reuse earlier target cell preparations after each handover to autonomously execute subsequent handovers. This saves the signaling overhead associated with the reconfiguration and repreparation of target cells after each handover. In this paper, a comprehensive study on the mobility performance of FCHO with respect to mobility failures and signaling overhead in frequency range 2 (FR2) is carried out. In particular, the performance of FCHO is compared with CHO for two different multi-panel UE (MPUE) schemes. Results show that FCHO substantially reduces the signaling overhead of CHO, while at the same time it also reduces mobility failures due to faster triggering of the handover that is achieved by saving the preparation delay.
Interactive manipulation of rigid body simulations (2000)

Physical simulation of dynamic objects has become commonplace in computer graphics because it produces highly realistic animations. In this paradigm the animator provides few physical parameters such as the objects' initial positions and velocities, and the simulator automatically generates realistic motions. The resulting motion, however, is difficult to control because even a small adjustment of the input parameters can drastically affect the subsequent motion. Furthermore, the animator often wishes to change the end-result of the motion instead of the initial physical parameters.
Micro Scale Heat Transfer Comparison between Packed Beds and Microfibrous Entrapped Catalysts (2013)

Computational Fluid Dynamics (CFD) was used to compare the micro scale heat transfer inside a packed bed and a microfibrous entrapped catalyst (MFEC) structure. Simulations conducted in stagnant gas determined the thermal resistance of the gas in the micro gaps between the particle-to-particle contact points in the resistance network model of a packed bed. Tube to particle diameter ratios for the simulations were 9 based on particle diameter and 27 for MFEC based on surface area average diameter. The maximum temperature difference used in the simulations was 80°C. It was shown that thermal resistance at the contact points accounted for 90% of the thermal resistance of the solid path. In the MFEC, the thermal resistance of the continuous metal fibers was relatively smaller than that of contact points. As a result, 97.2% of the total heat flux was transported by continuous fiber cylinders, which was the fundamental function of fibers on improving the heat transfer of MFEC structures. Enhanced heat transfer characteristics of MFEC were further demonstrated by simulations performed in flowing gas, where both heat conduction and heat convection were significant.
Differential regulation of human immunodeficiency viruses (HIVs): a specific regulatory element in HIV-2 responds to stimulation of the T-cell antigen receptor. (1990)

The human immunodeficiency viruses (HIVs) types 1 and 2 have similar genetic organization but differ significantly in nucleic acid sequence. Although infection by either agent leads to symptoms of immunodeficiency, recent studies suggest potential differences in the time course and severity of these diseases. In this report, the transcriptional regulation and induction of these retroviruses were analyzed. We report that the regulation of HIV-2 differs from that of HIV-1: a distinct T-cell activation pathway, triggering of the CD3 component of the T-cell receptor complex, stimulates HIV-2 but not HIV-1 gene expression. The response to T-cell receptor stimulation in HIV-2 is mediated partly by an upstream regulatory element, termed CD3R, which is recognized by a sequence-specific DNA binding protein, NF-CD3R. Jurkat T leukemia cell lines containing HIV-2 provirus also showed increased viral replication after stimulation of the T-cell receptor complex, in contrast to HIV-1. These findings suggest that transcriptional regulation and induction of HIV-2 differ from HIV-1 and raise the possibility that different cofactors contribute to the activation of HIV-1- and HIV-2-associated AIDS.