gebhart/patrepeval huggingface dataset:
Isomerization and Selective Hydrogenation of Propyne: Screening of Metal–Organic Frameworks Modified by Atomic Layer Deposition (2020)

Various metal oxide clusters upward of 8 atoms (Cu, Cd, Co, Fe, Ga, Mn, Mo, Ni, Sn, W, Zn, In, and Al) were incorporated into the pores of the metal-organic framework (MOF) NU-1000 via atomic layer deposition (ALD) and tested via high-throughput screening for catalytic isomerization and selective hydrogenation of propyne. Cu and Co were found to be the most active for propyne hydrogenation to propylene, and synergistic bimetallic combinations of Co and Zn, along with standalone Zn and Cd, were established as the most active for conversion to the isomerized product, propadiene. The combination of Co and Zn in NU-1000 diminished the propensity for full hydrogenation to propane as well as coking compared to its individual components. This study highlights the potential for high-throughput screening to survey monometallic and bimetallic cluster combinations that best affect the efficient transformation of small molecules, while discerning mechanistic differences in isomerization and hydrogenation by different metals.
Timing Synchronization for UWB Impulse Radios (2006)

This chapter contains sections titled: Introduction Signal Model Signal Detection and Symbol-Level Acquisition SAT and MAT: Templates with and without Timing Coarse Synchronization Using Symbol-Rate Samples Synchronization with Flexible Timing Resolution Timing Acquisition for Ad Hoc Multiple Access Demodulation and BER Sensitivity to Mistiming Concluding Summary References
Hand transplants and the mandate for tolerance (2014)

We believe that with the proper use of low-dose IL-2 given at an opportune time in the inflammatory process of transplant that reduce immunosuppression and even tolerance can be induced in hand transplantation. We propose that tolerance can be inducted after a long period of conventional treatment to avoid 'tolerance-hindering' adverse inflammation that occurs in the posttransplant period. With abatement of posttransplant inflammation and with time, we will institute low-dose IL-2-based therapy to support the proliferation, viability and functional phenotype of regulatory T cells.
Cardboard people: a parameterized model of articulated image motion (2002)

We extend the work of Black and Yacoob (1995) on the tracking and recognition of human facial expressions using parametrized models of optical flow to deal with the articulated motion of human limbs. We define a "card-board person model" in which a person's limbs are represented by a set of connected planar patches. The parametrized image motion of these patches in constrained to enforce articulated motion and is solved for directly using a robust estimation technique. The recovered motion parameters provide a rich and concise description of the activity that can be used for recognition. We propose a method for performing view-based recognition of human activities from the optical flow parameters that extends previous methods to cope with the cyclical nature of human motion. We illustrate the method with examples of tracking human legs of long image sequences.
Genome-Wide Profiling Identified a Set of miRNAs that Are Differentially Expressed in Glioblastoma Stem Cells and Normal Neural Stem Cells (2012)

A major challenge in cancer research field is to define molecular features that distinguish cancer stem cells from normal stem cells. In this study, we compared microRNA (miRNA) expression profiles in human glioblastoma stem cells and normal neural stem cells using combined microarray and deep sequencing analyses. These studies allowed us to identify a set of 10 miRNAs that are considerably up-regulated or down-regulated in glioblastoma stem cells. Among them, 5 miRNAs were further confirmed to have altered expression in three independent lines of glioblastoma stem cells by real-time RT-PCR analysis. Moreover, two of the miRNAs with increased expression in glioblastoma stem cells also exhibited elevated expression in glioblastoma patient tissues examined, while two miRNAs with decreased expression in glioblastoma stem cells displayed reduced expression in tumor tissues. Furthermore, we identified two oncogenes, NRAS and PIM3, as downstream targets of miR-124, one of the down-regulated miRNAs; and a tumor suppressor, CSMD1, as a downstream target of miR-10a and miR-10b, two of the up-regulated miRNAs. In summary, this study led to the identification of a set of miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells. Characterizing the role of these miRNAs in glioblastoma stem cells may lead to the development of miRNA-based therapies that specifically target tumor stem cells, but spare normal stem cells.
A Panel of Radiation Hybrids Defining the 7q31-q32 Region of Human Chromosome 7 (1996)

Mouse A9 cells containing human chromosome 7 tagged with pSV2neo were irradiated with X-rays and fused to A9 cells to isolate G418-resistant clones. From these clones, we selected radiation hybrids that contained 10-40 Mb of human DNA apparently at a single site of their genome by FISH analysis using human repetitive sequences as a probe. Then we made a panel of hybrids that contained various fragments of the 7q31-q32 region and cover its entire region altogether by PCR with STS markers of human chromosome 7. This panel is useful in chromosome transfer experiments since the dominant selective marker neo gene is attached to human DNA.
Aberrant Patterning of Neuromuscular Synapses in Choline Acetyltransferase-Deficient Mice (2003)

In this study we examined the developmental roles of acetylcholine (ACh) by establishing and analyzing mice lacking choline acetyltransferase (ChAT), the biosynthetic enzyme for ACh. As predicted, ChAT-deficient embryos lack both spontaneous and nerve-evoked postsynaptic potentials in muscle and die at birth. In mutant embryos, abnormally increased nerve branching occurs on contact with muscle, and hyperinnervation continues throughout subsequent prenatal development. Postsynaptically, ACh receptor clusters are markedly increased in number and occupy a broader muscle territory in the mutants. Concomitantly, the mutants have significantly more motor neurons than normal. At an ultrastructural level, nerve terminals are smaller in mutant neuromuscular junctions, and they make fewer synaptic contacts to the postsynaptic muscle membrane, although all of the typical synaptic components are present in the mutant. These results indicate that ChAT is uniquely essential for the patterning and formation of mammalian neuromuscular synapses.
The structure and electro‐mechanical properties of novel hybrid CNT/PANI nanocomposites (2013)

Electrically conductive elastomeric nanocomposites containing carbon nanotubes (CNT) and polyaniline (PANI) are reported in the present investigation. The synthesis procedure included an in situ inverse emulsion polymerization of aniline doped with dodecylbenzene sulfonic acid (DBSA) in the presence of CNT and dissolved styrene‐isoprene‐styrene (SIS) block copolymer. The PANI synthesis step was carried out by applying ultrasonic energy. The dispersions obtained were processed by two methods: a recently developed precipitation‐filtration procedure, and a conventional drop‐cast procedure. The techniques developed resulted in homogeneous exfoliated PANI coated nanotubes within the elastomeric matrix. The presence of CNT/PANI in the SIS elastomeric matrix affects thermal, mechanical, and electrical properties of the nanocomposites. The formation of continuous three‐dimensional CNT/PANI networks prepared via the precipitation‐filtration method enhances the nanocomposite properties. Contrarily, the intermittent three‐dimensional network prepared by conventional drop‐cast method leads to inferior properties. Nanocomposites produced by both techniques are observed by HRSEM. The two processing techniques result in different structures, which affect the physical properties of the materials produced. A relatively low percolation threshold for both methods was determined. The Young's modulus of the SIS/CNT/PANI significantly increased in the presence of CNT. The precipitation‐filtration technique yields an improved nanocomposite product compared to the drop‐cast route. POLYM. COMPOS., 35:788–794, 2014. © 2013 Society of Plastics Engineers
Who Is Stopping You? (2012)

Our early thoughts and feelings are heavily influenced by the opinions of the people who raise us and teach us, and even later in life we are shaped by the friends we choose. Your perspective will be greatly determined by the company you keep, by the people you hang around with. It's not easy to reject a notion that everyone around you believes, yet this is what we have to do if we want to make significant changes in our lives. It's extremely difficult to reprogram years of conditioning by our families, but if we don't challenge what they taught us, we could be inheriting their negativity and apathy. If we continue to believe that “people like us,” from our type of background, or our minority group, have limited opportunities, or face insurmountable obstacles, we will never be inspired to work towards improving our lives. If we don't believe we can achieve something, we will never even get close to getting there. No one knows this better than John Lee and Vincent Wong, both of whom had to defy their families' traditions and expectations in order to succeed and get to where they are today.
1286: The Relationship between PSA Isoforms and BPH-Related Prostate Volume at Baseline in the MTOPS Trial (2005)

You have accessJournal of UrologyModerated Poster, Tuesday, May 24, 2005, 1:00 - 3:00 pm1 Apr 20051286: The Relationship between PSA Isoforms and BPH-Related Prostate Volume at Baseline in the MTOPS Trial Kevin M. Slawin, Jonathan M. Levitt, Claus G. Roehrborn, John D. McConnell, Robert H. Getzenberg, M. Scott Lucia, Leif Peterson, William D. Noble, Dolores J. Lamb, Chris Mullins, Robert Star, John W. Kusek, and Leroy M. Nyberg Kevin M. SlawinKevin M. Slawin More articles by this author , Jonathan M. LevittJonathan M. Levitt More articles by this author , Claus G. RoehrbornClaus G. Roehrborn More articles by this author , John D. McConnellJohn D. McConnell More articles by this author , Robert H. GetzenbergRobert H. Getzenberg More articles by this author , M. Scott LuciaM. Scott Lucia More articles by this author , Leif PetersonLeif Peterson More articles by this author , William D. NobleWilliam D. Noble More articles by this author , Dolores J. LambDolores J. Lamb More articles by this author , Chris MullinsChris Mullins More articles by this author , Robert StarRobert Star More articles by this author , John W. KusekJohn W. Kusek More articles by this author , and Leroy M. NybergLeroy M. Nyberg More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)35431-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1286: The Relationship between PSA Isoforms and BPH-Related Prostate Volume at Baseline in the MTOPS Trial." The Journal of Urology, 173(4S), p. 349 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 349 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Kevin M. Slawin More articles by this author Jonathan M. Levitt More articles by this author Claus G. Roehrborn More articles by this author John D. McConnell More articles by this author Robert H. Getzenberg More articles by this author M. Scott Lucia More articles by this author Leif Peterson More articles by this author William D. Noble More articles by this author Dolores J. Lamb More articles by this author Chris Mullins More articles by this author Robert Star More articles by this author John W. Kusek More articles by this author Leroy M. Nyberg More articles by this author Expand All Advertisement PDF downloadLoading ...
Molecular Regulation of Membrane Resealing in 3T3 Fibroblasts (2004)

Membrane resealing in mammalian cells after injury depends on Ca(2+)-dependent fusion of intracellular vesicles with the plasma membrane. When cells are wounded twice, the subsequent resealing is generally faster. Physiological and biochemical studies have shown the initiation of two different repair signaling pathways, which are termed facilitated and potentiated responses. The facilitated response is dependent on the generation and recruitment of new vesicles, whereas the potentiated response is not. Here, we report that the two responses can be differentially defined molecularly. Using recombinant fragments of synaptobrevin-2 and synaptotagmin C2 domains we were able to dissociate the molecular requirements of vesicle exocytosis for initial membrane resealing and the facilitated and potentiated responses. The initial resealing response was blocked by fragments of synaptobrevin-2 and the C2B domain of synaptotagmin VII. Both the facilitated and potentiated responses were also blocked by the C2B domain of synaptotagmin VII. Although the initial resealing response was not blocked by the C2AB domain of synaptotagmin I or the C2A domain of synaptotagmin VII, recruitment of new vesicles for the facilitated response was inhibited. We also used Ca2+ binding mutant studies to show that the effects of synaptotagmins on membrane resealing are Ca(2+)-dependent. The pattern of inhibition by synaptotagmin C2 fragments that we observed cannot be used to specify a vesicle compartment, such as lysosomes, in membrane repair.
Formation of two-dimensional colloid crystals in liquid films under the action of capillary forces (1994)

When two similar small particles are attached to a liquid interface they attract each other due to a lateral capillary force. This force appears because the gravitational potential energy of the floating particles decreases when they are approaching each other. This force is proportional to R6 (R is the particle radius), so it decreases very fast with particle size and becomes negligible for R<10 mu m. We found that the situation is quite different when the particles (instead of being freely floating) are partially immersed in a liquid layer on a substrate. In this case the energy of capillary attraction is proportional to R2 and turns out to be much larger than kT even with particles of diameter about 10 nm. The effect is related to the particle three-phase contact angle, i.e. to the intermolecular forces, rather than to gravity. The experiments show that the lateral capillary forces can bring about the formation of a two-dimensional array (2D-crystal) from both micrometre-size and submicrometre particles: latex spheres, protein globules, etc.
Crash Testing and Evaluation of the Shur-Tite® Multiple-Mailbox Mount (2006)

Because mailboxes along roadsides can be hazardous to drivers, they must meet crashworthiness standards. This paper summarizes research that was conducted to evaluate a new multiple-mailbox system designed by Shur-Tite®. Two full-scale crash tests were conducted to evaluate the safety performance of the Shur-Tite® multiple-mailbox support in accordance with National Cooperative Highway Research Program (NCHRP) Report 350 criteria. In both tests, the mount yielded to the vehicle by pulling out of the ground socket. The support did not penetrate or show potential for penetrating the occupant compartment or present undue hazard to others in the area. The vehicle remained upright during and after the collision event. Occupant risk factors were within preferred limits. The Shur-Tite® Multiple-Mailbox Mount design passed all requirements of NCHRP Report 350. The design is now ready for field implementation.
β3-Adrenoceptor Is the Predominant β-Adrenoceptor Subtype in Human Myometrium and Its Expression Is Up-Regulated in Pregnancy (2005)

To assess whether pregnancy might influence the functionality and expression of human myometrial beta(2)- and beta(3)-adrenoceptors (beta(2)- and beta(3)-AR), we performed functional, binding, Western blot, and molecular biology experiments in human nonpregnant and near-term pregnant myometrium. Inhibition of spontaneous contractions induced by a beta(3)-AR agonist, SR 59119A, was significantly greater in pregnant, compared with nonpregnant, myometrial strips (E'(max) = 61 +/- 5% vs. 44 +/- 5% for pregnant and nonpregnant myometrium, respectively), whereas salbutamol, a beta(2)-AR agonist, was significantly less efficient in pregnant, compared with nonpregnant, myometrium (E(max) = 29 +/- 4 vs. 54 +/- 8%). Although two populations of binding sites corresponding to beta(2)- and beta(3)-AR were identified in both nonpregnant and pregnant myometrium, we found a clear predominance of the beta(3)-AR subtype. Moreover, beta(3)-AR binding sites were up-regulated 2-fold in myometrium at the end of pregnancy. Both beta(2)- and beta(3)-AR mRNA were expressed in human nonpregnant and pregnant myometrium. Contrary to beta(2)-AR, the expression of the beta(3)-AR transcripts and immunoreactive proteins was increased in pregnant, compared with nonpregnant, myometrium. Such compelling data suggest a predominant role for beta(3)-AR in the regulation of human myometrium contractility, especially at the end of pregnancy, which might have important consequences for the clinical management of preterm labor.
Effect of Particle Size on Gas Permeability of Filled Superglassy Polymers (2004)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTEffect of Particle Size on Gas Permeability of Filled Superglassy PolymersAnthony L. Andrady, Timothy C. Merkel, and Lora G. ToyView Author Information Centers for Aerosol Technology and Energy Technology, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194 Cite this: Macromolecules 2004, 37, 11, 4329–4331Publication Date (Web):April 28, 2004Publication History Received11 March 2004Revised19 March 2004Published online28 April 2004Published inissue 1 June 2004https://pubs.acs.org/doi/10.1021/ma049510uhttps://doi.org/10.1021/ma049510ubrief-reportACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views692Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Nanoparticles,Permeability,Polymer particles,Polymers,Silica Get e-Alerts
The next big thing: position statements (1997)

This panel is a celebration of artificial intelligence (AI). Basing its claims to interest on the past accomplishments of AI, it highlights some of the new exciting concepts and technologies that compete for the title The Next Big Thing. 1 Introduction It is well-known among artificial intelligence (AI) researchers that AI has made significant contributions to computing research and practice. This fact is not always recognized in the rest of the computing community. Indeed, many people believe that &amp;quot;what works isn&amp;apos;t AI.&amp;quot; This is only half true. AI has traditionally focused on challenging problems, and when a problem is about to be understood, AI researchers tend to move to something more interesting. Indeed, topics that were identified by AI researchers, but are considered mainstream today include, among others ffl functional programming ffl object-oriented programming ffl agents. This panel seeks to identify the next major AI contributions to the rest of computing, while they are ...
[Presence of a substance immunologically related to somaliberin extracted from human pancreatic tumor (hpGRF) in neurons of the hypophysiotropic area in the guinea-pig and rat]. (1983)

An antiserum raised against the synthetic human pancreatic tumour GRF (hpGRF) made it possible to localize an immunoreactive material in 100 nm granules of nerve terminals distributed in the external layer of the median eminence in Guinea-Pig and Rat. Moreover, especially in colchicine-treated Guinea-Pigs, numerous stained perikarya were observed, exclusively located in the arcuate nucleus. These results suggest that hypothalamic GRF is very similar, if not identical, to hpGRF.
Nanopores: general discussion (2016)

Serge Lemay opened a general discussion of the paper by Wolfgang Schmickler: Since a nanotube effectively forms a Faraday cage, it is not possible to generate a longitudinal DC electric field inside the nanotube. Any externally applied potential difference between the two reservoirs at the ends
PDGFRA Defines the Mesenchymal Stem Cell Kaposi’s Sarcoma Progenitors by Enabling KSHV Oncogenesis in an Angiogenic Environment (2019)

ABSTRACT Kaposi’s sarcoma (KS) is an AIDS-defining cancer caused by the KS-associated herpesvirus (KSHV). Unanswered questions regarding KS are its cellular ontology and the conditions conducive to viral oncogenesis. We identify PDGFRA(+)/SCA-1(+) bone marrow-derived mesenchymal stem cells (Pα(+)S MSCs) as KS spindle-cell progenitors and found that pro-angiogenic environmental conditions typical of KS are critical for KSHV sarcomagenesis. This is because growth in KS-like conditions generates a de-repressed KSHV epigenome allowing oncogenic KSHV gene expression in infected Pα(+)S MSCs. Furthermore, these growth conditions allow KSHV-infected Pα(+)S MSCs to overcome KSHV-driven oncogene-induced senescence and cell cycle arrest via a PDGFRA-signaling mechanism; thus identifying PDGFRA not only as a phenotypic determinant for KS-progenitors but also as a critical enabler for viral oncogenesis. AUTHOR SUMMARY Identification of the KS progenitor cell creates the possibility of studying viral oncogenesis and its determinants from its initial steps as a continuum. It also increases our understanding of pathogenic mechanisms and disease preferential tropism. Hereby we identify Pα(+)S-MSCs as KS progenitors, in which KSHV infection has oncogenic consequences; only when these cells are in a pro-angiogenic environment in which PDGFRA activation enables an oncogenic de-repressed KSHV epigenome. These results identify a KS-progenitor population in the Pα(+)S-MSCs and point to pro-angiogenic environmental conditions as essential for oncogenic viral gene expression and transformation. We designed a novel model of KSHV oncogenesis, creating a very robust platform to identify KSHV oncogenic pathways and their relationship with cellular lineages and extracellular growth environments.
Elastography for Muscle Biomechanics (2015)

Estimation of individual muscle force remains one of the main challenges in biomechanics. This review presents a series of experiments that used ultrasound shear wave elastography to support the hypothesis that muscle stiffness is linearly related to both active and passive muscle forces. Examples of studies that used measurement of muscle stiffness to estimate changes in muscle force are presented.