gebhart/patrepeval huggingface dataset:
Gone Cloning and Expression of a Morphogenetic Protein Derived From a Murine Osteosarcoma (1993)

Based on information from partial amino acid sequences of a protein with bone-inducing activity that was purified from a murine osteosarcoma (Dunn type), a cDNA library of the sarcoma was screened to clone a gene complementary to the protein. The cloned cDNA was amplified and transfected into Chinese hamster ovarian (CHO) cells for expression. When the protein produced by the transfected cell line was implanted in combination with pure carrier collagen into allogeneic mice, ectopic ossicles consistently developed at implanted sites within two weeks. The nucleotide sequence of the cDNA and its deduced amino acid sequence were homologous to those of human bone morphogenetic protein-4 (also BMP-2B). In addition, the cDNA and deduced amino acid sequences were identical to those proposed for murine BMP-4 derived from the normal murine fetus. It is postulated that the cloned cDNA encodes the protein responsible for bone formation induced by implantation of devitalized Dunn-type osteosarcoma tissue or cells. The protein product was identified as murine BMP-4, a member of the TGF-beta gene family.
High-speed HD DVD-R disc with organic dye (2007)

High speed HD DVD-R disc with low-to-high polarity organic dye was developed. For development of organic dye, Type A and Type B having different properties in sensitivity and read stability were examined. 4x speed recording is possible with both Type A and Type B. Furthermore, in type B, the sufficient signal characteristics were obtained at 5x speed recording for single layer disc and 2x speed recording for dual layer disc.
Analyte (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Optimisation de la télé-alimentation des systèmes RFID UHF grâce à la modélisation comportementale du lien RF (2003)

National audience
Activity and function recognition for moving and static objects in urban environments from wide-area persistent surveillance inputs (2010)

In this paper, we describe results from experimental analysis of a model designed to recognize activities and functions of moving and static objects from low-resolution wide-area video inputs. Our model is based on representing the activities and functions using three variables: (i) time; (ii) space; and (iii) structures. The activity and function recognition is achieved by imposing lexical, syntactic, and semantic constraints on the lower-level event sequences. In the reported research, we have evaluated the utility and sensitivity of several algorithms derived from natural language processing and pattern recognition domains. We achieved high recognition accuracy for a wide range of activity and function types in the experiments using Electro-Optical (EO) imagery collected by Wide Area Airborne Surveillance (WAAS) platform.
ORBITAL TOPOLOGIES (1953)

ORBITAL TOPOLOGIES Get access D. ELLIS D. ELLIS University of Florida Search for other works by this author on: Oxford Academic Google Scholar The Quarterly Journal of Mathematics, Volume 4, Issue 1, 1953, Pages 117–119, https://doi.org/10.1093/qmath/4.1.117 Published: 01 January 1953 Article history Received: 16 May 1952 Published: 01 January 1953
A Method for Assessing the Impact of Secondary and Tertiary Reactions on Sandstone Acidizing Treatments (2005)

Acid stimulation of sandstone reservoirs can lead to substantial production improvements of hydrocarbons and can considerably enhance the economic value of a well. However, this technique is still considered risky because of secondary and tertiary reactions between the spent acid and the rock. Precipitates resulting from these reactions can deposit in the pores of the rock and eventually negate the positive impact of the primary reaction. Being able to assess the extent of the secondary and tertiary reactions under reservoir conditions is therefore critical for the acid treatment success. Traditional methods to evaluate overall treatment impact consist of injecting acid through a short core and measuring the change in permeability. However, these methods only capture accurately the impact of the primary dissolution reaction. The much slower secondary and tertiary reactions occur over time scales greater than the acid residence time in the core, and therefore cannot be fully taken into account by these experiments. This paper presents a new and economical technique to assess the extent of those reactions under reservoir conditions. It relies on one or two experiments performed on short cores of 2.5 to 15 cm to determine surface areas of reservoir minerals. This information is then incorporated in a geochemical simulator. The simulator includes an extensive database of reaction kinetics and thermodynamics properties of various acids and by-products with the minerals commonly encountered in sandstone reservoirs. Radial flow, reservoir heterogeneities, and damage mineralogy are rigorously accounted for and allow one to scale up to reservoir conditions. The type, amount, and location of precipitates can then be determined. This information is used to optimize the stimulation treatment. This methodology was successfully applied to three treatments. - The first case study considers a well in the Gulf of Thailand. The high temperature of the formation, which favors precipitation of silica, and the high carbonate content were challenges for the design of the treatment. - The second case study considers a well in the Norwegian Sea. A high degree of reservoir heterogeneity had to be accounted for in order to scale up the treatment to reservoir conditions. Without prior acidizing experience in this formation, a reliable means of designing the treatment was required. - The third case study considers a well in the North Sea. The new technique was applied to determine the damage due to secondary and tertiary reactions from an acidizing treatment on a well in the Galley field, after operational issues caused the acid to stay in the formation over a long period of time. For the first two cases, various fluid formulations were tested and sensitivity analyses were performed to improve damage removal and minimize the formation of precipitates. The results provided accurate guidelines for the design of the treatments.
Reliably assessing the electronic structure of cytochrome P450 on today's classical computers and tomorrow's quantum computers (2022)

An accurate assessment of how quantum computers can be used for chemical simulation, especially their potential computational advantages, provides important context on how to deploy these future devices. In order to perform this assessment reliably, quantum resource estimates must be coupled with classical simulations attempting to answer relevant chemical questions and to define the classical simulation frontier. Herein, we explore the quantum and classical resources required to assess the electronic structure of cytochrome P450 enzymes (CYPs) and thus define a classical-quantum advantage boundary. This is accomplished by analyzing the convergence of DMRG+NEVPT2 and coupled cluster singles doubles with non-iterative triples (CCSD(T)) calculations for spin-gaps in models of the CYP catalytic cycle that indicate multireference character. The quantum resources required to perform phase estimation using qubitized quantum walks are calculated for the same systems. Compilation into the surface-code provides runtime estimates to compare directly to DMRG runtimes and to evaluate potential quantum advantage. Both classical and quantum resource estimates suggest that simulation of CYP models at scales large enough to balance dynamic and multiconfigurational electron correlation has the potential to be a quantum advantage problem and emphasizes the important interplay between classical simulations and quantum algorithms development for chemical simulation.
Real-time audio signal capture and processing using MATLAB object oriented programming (2013)

In MATLAB programming language the real-time audio processing functions are usually simulated in non-real-time due to a lack of real-time audio programming support. As a result the real-time audio signal capture and processing functionalities are usually implemented in other programming languages and cannot utilize the extensive signal processing functionalities provided by MATLAB. In this paper we introduce a MATLAB real-time signal processing framework based on MATLAB timer object and audiorecorder object. The proposed processing framework serves as an alternative solution for real-time programming implementation and demonstration. In our proposed processing framework the timer object is implemented to handle the looping of processing cycle, schedule the signal processing tasks, and handle the error processing. The audio capturing/processing functionality is implemented in the timer cycle by using two audiorecorder objects that read the audio streaming data and feed a segment of data to signal processing alternatively. The proposed framework achieves satisfactory real-time performance with no missing audio frames when a short audio delay setting of 10ms is applied. Several application examples of our proposed framework are also demonstrated.
Simplified Realization of Zero Phase Error Tracking (2020)

Abstract Zero phase error tracking (ZPET) control has gained popularity as a simple yet effective feedforward control method for tracking time varying desired trajectories by the plant output of a continuous time transfer function of relative order greater than or equal to two. In this paper, we will note that the sampling zeros of the zero-order hold equivalent of chain of integrators, 1/sn, are configured for natural realization of zero phase error tracking. This property is exploited to realize a simplified realization of zero phase error tracking control for chain of integrators. The property can also be utilized for general transfer functions when the sampling period for digital control is small. The effectiveness of the proposed approach for general transfer functions is demonstrated by simulations.
Usefulness of HepaRG cells in the mitochondrial function assay for the estimation of potential risk of idiosyncratic drug-induced liver injury (2020)

Drug-induced liver injury (DILI) is one of the serious and frequent drug-related adverse events and is classified into intrinsic and idiosyncratic types. Almost all of DILI caused in humans is known to be idiosyncratic type. The estimation of the potential risk for a drug candidate to induce idiosyncratic DILI is important to facilitate the development of new drugs, however, the estimation is difficult from the results of non-clinical toxicity studies using animals. We have previously reported the in vitro combination assay of mitochondrial function and apoptosis using human primary hepatocytes as a useful model for estimation of the risk of idiosyncratic DILI. In this study, to improve the in vitro assay for estimation of the risk of idiosyncratic DILI, we evaluate the usefulness of HepaRG cells for the mitochondrial function assay. We measured the oxygen consumption rate (OCR) as an endpoint of mitochondrial function in HepaRG cells treated with some compounds causing idiosyncratic DILI (troglitazone, leflunomide, ranitidine and diclofenac) and others known not to cause idiosyncratic DILI (acetaminophen and ethanol) and compared the results in HepaRG cells and with those for human primary hepatocytes as previously reported. As the results, HepaRG cells showed comparable or even higher sensitivity for detecting mitochondrial dysfunction than human primary hepatocytes, in all tested compounds. Taking into account these results and many other useful properties of the cells, HepaRG cells are considered to be much more suitable for this mitochondrial function assay than the human primary hepatocytes.
Synthesis and Electroluminescent Properties of Blue-Light-Emitting Arylene Derivatives End-Capped with Thiophene Groups (2012)

Abstract In this study, four blue fluorescent arylenes end-capped with thiophene derivatives have been synthesized. To explore electroluminescent properties of these molecules, multilayer OLEDs device structure of ITO/NPB/EML/BPhen/Al were fabricated. Two multilayer devices, using 3–4, showed the efficient deep blue emissions with CIE x,y of (0.159, 0.092) and (0.151,0.082) at 9.0 V, and the external quantum efficiencies of 1.60 and 0.80%, respectively. A PFVtPh doped-device exhibited the highly efficient blue emission with a maximum luminance of 3480 cd m−2 at 9.0 V, the external quantum efficiency of 5.23%, and CIE x,y of (0.151, 0.185) at 9.0 V. Keywords: blue OLEDsfluorescencehostsuzuki cross-coupling reactionthiophene group Acknowledgments This work was supported by a grant 20110004655 from the Korea Science and Engineering Foundation.
Modelling of HVDC breakers for HVDC grid simulations (2017)

This paper deals with the modelling of high-voltage direct current (HVDC) breakers in PSCAD. The models are aimed at HVDC grid simulation and are kept as simple as possible. An overview is given ov ...
Target discovery for T cell therapy: next steps to advance Immunotherapies (2015)

Investigators from academia and industry gathered on August 14, 2014, in Boston at the Inaugural ImVacS conference entitled “Target Discovery for T Cell Therapy: Next Step to Advance Immunotherapies”. Novel targets, discovery strategies and enabling technologies were presented and discussed.
The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells (2021)

N-terminal HSP90 inhibitors in development have had issues arising from heat shock response (HSR) induction and off-target effects. We sought to investigate the capacity of NCT-58, a rationally-synthesized C-terminal HSP90 inhibitor, to kill trastuzumab-resistant HER2-positive breast cancer stem-like cells. NCT-58 does not induce the HSR due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills the rapidly proliferating bulk tumor cells as well as the breast cancer stem-like population, coinciding with significant reductions in stem/progenitor markers and pluripotent transcription factors. NCT-58 treatment suppressed growth and angiogenesis in a trastuzumab-resistant xenograft model, concomitant with downregulation of ICD-HER2 and HSF-1/HSP70/HSP90. These findings warrant further investigation of NCT-58 to address trastuzumab resistance in heterogeneous HER2-positive cancers.
Regeneration Strategies for Gasoline Particulate Filters (2019)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Gasoline particulate filters (GPFs) are extremely effective at reducing tailpipe emissions of particulate mass and particulate number. Especially in the European and Chinese markets, where a particulate number standard is legislated, we see gasoline particulate filters being deployed in production on gasoline direct injected engines. Due to the high temperature in gasoline exhaust, most applications are expected to be passively regenerating without the help of an active regeneration strategy. However, for the few cases where a customer drive cycle has consistently low speed over a long time frame, an active regeneration strategy may be required. This involves increasing the exhaust temperature at the GPF up to around 600 degC so that soot can be combusted. We compare two different ways of achieving these temperatures, namely spark retard and air fuel ratio modulation. The former generates heat in the engine, the latter generates heat in one or more catalysts in the exhaust system. We list some benefits and drawbacks of both methods, and validate our work with experimental data.&lt;/div&gt;&lt;/div&gt;
On clustering images of objects (2005)

The images of an object may look very different under different illumination conditions or viewing directions. This thesis considers the problem of clustering images of various objects according to object identity. The clustering problem has been studied for decades and currently it is one of the most active research fields in machine learning. Compared to other data types, images are practically very important, but they are very difficult to be handled due to lack of understandings on their intrinsic properties. 
First, the hypergraph partitioning problem is addressed, and a new two-step algorithm for solving this problem is proposed. The proposed algorithm first builds a graph approximation of the hypergraph with a novel approximation scheme, then a spectral graph partitioning algorithm is applied to generate the final clustering result. 
Given powerful general clustering algorithms, the key step for image clustering is to design an effective similarity measure between images. In this thesis, according to the imaging conditions, three different similarity measures are presented. When the relative position between objects and the camera is fixed but the illumination in the environment changes, the conic affinity and the gradient affinity gives excellent clustering result. For each image, the conic affinity assigns non-negative weights to the neighboring images, which represents the likelihood of being from the same object. The gradient affinity works in a pairwise manner. It directly compares two images based on the probabilistic distribution of the image gradient vectors under different illumination. 
Dealing with viewing direction changes is harder since these images do not have a simple global structure in the image space. The local linear structure between nearby images is exploited to determine the closeness between images. By considering affine warps of the images, small 3D pose variation can be handled, which enhances the clustering result over pose variation. 
When the lighting and pose variation occurs simultaneously, we do not have a reasonably good clustering algorithm yet. A few candidate algorithms are tested and the result are given in this thesis. Finding an effective similarity measure for both changes still remains as an open problem.
Supramolecular Structures of Inclusion Complexes of Cyclic Porphyrin Dimers and [6,6]-Phenyl-C61-Butyric Acid Methyl Ester (PCBM) (2012)

Abstract Cyclic nickel and free-base porphyrin dimers (Ni2-CPDPy and H4-CPDPy) include [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) both in solution and in the crystals. In the crystal packing of the inclusion complex of Ni2-CPDPy and PCBM, a nanotubular structure is constructed through the self-assembly of the porphyrin moiety. The PCBM molecules are linearly arranged in the inner channel of the nanotube to give a supramolecular peapod. On the other hand, in the crystal of the inclusion complex of H4-CPDPy and PCBM, a dimeric structure of the PCBM molecules is formed through π–π interaction between their phenyl groups.
Increasing Resolution with a New Method for Efficient Broadband Marine Acquisition and Processing (2009)

We present a new method for broadband marine acquisition and processing. A 3D shallow towed-streamer spread is deployed, designed to optimize the mid- and high-frequency parts of the bandwidth. In addition, data are simultaneously acquired from a small number of deeper towed streamers. The depth of these deeper streamers is optimized for the low frequencies such that the combined overall bandwidth is enhanced. Because the deep streamers only provide the low-frequency part of the bandwidth, we can more sparsely sample these data enabling efficient acquisition scenarios as fewer streamers are required. A 3D case study using this new acquisition method was acquired off the NW Shelf of Australia. The streamer spread consisted of six shallow streamers towed at a depth of 6 m and two deeper streamers (below shallow streamers 2 and 5) towed at a depth of 20 m. The resulting data exhibit both high resolution and deep penetration for subsalt and sub-basalt imaging, for example. In addition, inversion for acoustic impedance, imaging, and velocity model building, also benefit from the broadband result. Data acquired in this way are more robust to poor weather conditions than conventionally acquired data.
Metro Field Trial of 100 Gb/s Channel Transmission over Mixed-Fiber with Real-Time Data Processing (2011)

We present results from a transmission field trial for a cost-efficient 107 Gb/s channel using real-time data processing. The channel bit error ratio (BER) was sufficient for error-free performance after FEC for a 150 km mixed SSMF and DSF metro route in the Berlin area as part of the OCTET test bed. The DPSK-3ASK modulation format used in the trial was investigated as a lower-cost, metro-focused alternative to the DP-QPSK format, and was assembled using commercially available serializer and deserializer ICs and FPGA. Transmission results as well as latency measurements over a pair of 10GbE tributaries are described. Additionally, post-trial laboratory results for transmission distances up to 430 km with standard single-mode fiber are presented.
ChemInform Abstract: NEW SYNTHESES OF MACROCYCLIC LACTONES (1984)

Abstract Die Acetale (I) langkettiger Hydroxy‐aldehyde reagieren mit dem Ketenyliden‐phosphoran (II) zu den Yliden (III), die zu den Phosphosphoniumsalzen (IV) mit freier Aldehydgruppe hydrolysiert werden.