gebhart/patrepeval huggingface dataset:
STRUCTURAL AND FUNCTIONAL ASPECTS OF NON-BILAYER LIPIDS IN MEMBRANES (1981)

Conference Abstract| April 01 1981 STRUCTURAL AND FUNCTIONAL ASPECTS OF NON-BILAYER LIPIDS IN MEMBRANES B. de Kruijff; B. de Kruijff (1)Dept. of Mol. Biol., University of Utrecht, Padualaan 8, Utrecht, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar A. J. Verkleij; A. J. Verkleij (1)Dept. of Mol. Biol., University of Utrecht, Padualaan 8, Utrecht, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar C. J. A. van Echteld; C. J. A. van Echteld (2)Dept. of Biochemistry, University of Utrecht, Padualaan 8, Utrecht, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar W. J. Gerritsen; W. J. Gerritsen (2)Dept. of Biochemistry, University of Utrecht, Padualaan 8, Utrecht, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar C. A. Mombers; C. A. Mombers (2)Dept. of Biochemistry, University of Utrecht, Padualaan 8, Utrecht, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar P. C. Noordam; P. C. Noordam (2)Dept. of Biochemistry, University of Utrecht, Padualaan 8, Utrecht, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar J. de Gier; J. de Gier (2)Dept. of Biochemistry, University of Utrecht, Padualaan 8, Utrecht, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar P. R. Cullis P. R. Cullis (3)Dept. of Biochemistry, University of British Columbia, Vancouver, Canada V6T IW5 Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1981) 9 (2): 113P. https://doi.org/10.1042/bst009113pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation B. de Kruijff, A. J. Verkleij, C. J. A. van Echteld, W. J. Gerritsen, C. A. Mombers, P. C. Noordam, J. de Gier, P. R. Cullis; STRUCTURAL AND FUNCTIONAL ASPECTS OF NON-BILAYER LIPIDS IN MEMBRANES. Biochem Soc Trans 1 April 1981; 9 (2): 113P. doi: https://doi.org/10.1042/bst009113pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1981 Biochemical Society1981 Article PDF first page preview Close Modal You do not currently have access to this content.
Ligands of the nicotinic acetylcholine receptor as insecticides (1999)

Insect nicotinic acetyl receptors (nAChR) are targets of growing importance and, since the early 1990s, the number of such highly effective insecticides as imidacloprid and spinosyn has grown. Several natural compounds, eg dihydro-β-erythroidine, methyl caconitine and paraherquamide, showing high affinity to the same receptor, were considerably less active as insecticides, most likely because of their antagonistic action. Our observations on aphids after ingestion of the antagonistic compound dihydro-β-erythroidine revealed anti-feedant-like properties. As a consequence, the symptomology of poisoning was totally different between agonists and antagonists of the nAChR. Electrophysiological (whole-cell voltage clamp) measurements in isolated housefly neurones revealed that agonism seems to be a prerequisite for insecticidal activity. Furthermore, we were able to demonstrate the existence of two different subtypes of the nAChR in isolated locust neurones with different pharmacology and ion-channel properties.
Characterization of Key Sexually Dimorphic Regulators in Pain Processing (2019)

Introduction/Aim: Chronic pain affects 1 in 5 Canadians and costs over $43B annually, yet effective and safe treatment options remain elusive. Recent discoveries have brought to the forefront sex differences in mechanisms of pain as a potential explanation why novel pre-clinical therapeutics have not translated into successfully in clinical trials. Methods: To begin understanding how males and females differ in pain processing, we analyzed gene expression, using RNA sequencing, and DNA methylation, using reduced representation bisulfite sequencing (RRBS), in rodent models of neuropathic pain. Results: Across both sexes, our data reveals peripheral nerve injury (PNI) caused upregulation of 61 genes involved in innate immune responses in spinal cord. In females specifically, we observed PNI-induced downregulation of 5 genes involved in neuronal function and upregulation of two classes of Cathepsins. (C and E). On the other hand, in males, we observed upregulation of 14 genes including those involved in metabolism of purines and glutathione. Additionally we found that PNI leads to methylome remodeling in a sexually dimorphic manner: 125 promoters in rat spinal cord that were differentially methylated in injured males versus females. Discussion/Conclusions: Our data shows robust sex specific DNA methylation and transcriptome signature after PNI. Additionally, our findings leads to the hypothesis that remapping of DNA methylation, with subsequent alterations in the transcriptome, are critically involved in the development of neuropathic pain. We anticipate that future research directed at understanding these differences may lead to effective drug development to combat chronic pain.
Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera (2022)

Due to differences in human and murine angiotensin converting enzyme 2 (ACE-2) receptor, initially available SARS-CoV-2 isolates could not infect mice. Here we show that serial passaging of USA-WA1/2020 strain in mouse lungs results in "mouse-adapted" SARS-CoV-2 (MA-SARS-CoV-2) with mutations in S, M, and N genes, and a twelve-nucleotide insertion in the S gene. MA-SARS-CoV-2 infection causes mild disease, with more pronounced morbidity depending on genetic background and in aged and obese mice. Two mutations in the S gene associated with mouse adaptation (N501Y, H655Y) are present in SARS-CoV-2 variants of concern (VoCs). N501Y in the receptor binding domain of viruses of the B.1.1.7, B.1.351, P.1 and B.1.1.529 lineages (Alpha, Beta, Gamma and Omicron variants) is associated with high transmissibility and allows VoCs to infect wild type mice. We further show that S protein mutations of MA-SARS-CoV-2 do not affect neutralization efficiency by human convalescent and post vaccination sera.
Pulsed laser emission at 2.3μm in a thulium-doped fluorozirconate fibre (1988)

We report for the first time laser emission at 2.3μ from a thulium-doped fluorozirconate fibre pumped by a pulsed alexandrite laser at 0.786μm. Threshold occurs at 25μd incidenton the focusing lens. This wavelength is in the 2–3 n ultra-low loss region of fluorozirconate fibres. Furtherimprovement is expected to result in CW operation using diode laser pumping.
Unextendible maximally entangled bases (2009)

We introduce the notion of the unextendible maximally entangled basis (UMEB), a set of orthonormal maximally entangled states in d \times d consisting of fewer that d^2 vectors which have no additional maximally entangled vectors orthogonal to all of them. We prove that UMEBs don't not exist for d=2 and give an explicit constructions for a 6-member UMEB with d=3 and a 12-member UMEB with d=4.
Supplementary Figure S2 from Human Leukocyte Antigen–Presented Macrophage Migration Inhibitory Factor Is a Surface Biomarker and Potential Therapeutic Target for Ovarian Cancer (2023)

&lt;p&gt;RL21A targets MIF&lt;sub&gt;19-27&lt;/sub&gt; in other HLA-A*02:0x alleles.&lt;/p&gt;
Cost and Coding Efficient Motion Estimation Design Considerations for High Efficiency Video Coding (HEVC) Standard (2013)

This paper focuses on motion estimation engine design in future high-efficiency video coding (HEVC) encoders. First, a methodology is explained to analyze hardware implementation cost in terms of hardware area, memory size and memory bandwidth for various possible motion estimation engine designs. For 11 different configurations, hardware cost as well as the coding efficiency are quantified and are compared through a graphical analysis to make design decisions. It has been shown that using smaller block sizes (e.g. 4 × 4) imposes significantly larger hardware requirements at the expense of modest improvements in coding efficiency. Secondly, based on the analysis on various configurations, one configuration is chosen and algorithm improvements are presented to further reduce hardware implementation cost of the selected configuration. Overall, the proposed changes provide 56 × on-chip bandwidth, 151 × off-chip bandwidth, 4.3 × core area and 4.5 × on-chip memory area savings when compared to the hardware implementation of the HM-3.0 design.
DETNET crosshauling requirements (2016)

Future 5G networks will not make a clear distinction between fronthaul
and backhaul transport networks, because varying portions of radio
access network functionality might be moved toward the network as
required for cost reduction and performance increase. This will pose
additional challenges on the transport network, driving for a new
design of integrated fronthaul and backhaul, usually referred to as
crosshaul. This document present the crosshaul architecture framework
being developed by the EU 5G-Crosshaul project, as well as identifies
several key requirements for the transport network, with the goal of
fostering discussion at the DETNET WG.
Perceptual quality of BRDF approximations: dataset and metrics (2021)

Abstract Bidirectional Reflectance Distribution Functions (BRDFs) are pivotal to the perceived realism in image synthesis. While measured BRDF datasets are available, reflectance functions are most of the time approximated by analytical formulas for storage efficiency reasons. These approximations are often obtained by minimizing metrics such as L 2 —or weighted quadratic—distances, but these metrics do not usually correlate well with perceptual quality when the BRDF is used in a rendering context, which motivates a perceptual study. The contributions of this paper are threefold. First, we perform a large‐scale user study to assess the perceptual quality of 2026 BRDF approximations, resulting in 84138 judgments across 1005 unique participants. We explore this dataset and analyze perceptual scores based on material type and illumination. Second, we assess nine analytical BRDF models in their ability to approximate tabulated BRDFs. Third, we assess several image‐based and BRDF‐based (L p , optimal transport and kernel distance) metrics in their ability to approximate perceptual similarity judgments.
Percutaneous transcatheter filter for the inferior vena cava. A new device for treatment of patients with pulmonary embolism. (1984)

A filter for the inferior vena cava has been devised for treatment of pulmonary embolism. Percutaneous insertion of the filter is accomplished with the use of a sheath and an 8-F catheter. Therapeutic results involving 28 patients have been excellent. No embolism has recurred; no vena cava thrombosis has developed. Since minor surgery is unnecessary, the procedure saves time and is cost-effective.
Interference Direction Finding for Aviation (1999)

The Local Area Augmentation System(LAAS) is being de-veloped
by the US Federal Aviation Administration (FAA)
to provide satellite navigation performance compliant with
the stringent requirements for aircraft precision approach
and landing. A primary design goal for LAAS is to in-sure
that failures occurring in the ground or space segments
be eliminated by the ground system before differential cor-rections
are broadcast to users. One such failure is unin-tentional
interference or intentional jamming in the GPS
frequency band. To protect availability, ground person-nel
must also be able to locate and disable the interference
source.
To serve this purpose, the LAAS Ground Facility may well
include an Interference Direction Finder (IDF). The IDF
can improve LAAS availability by rapidly and accurately estimating the location of the source. IDF activities are
implemented in parallel with reference receiver functions
and may share components with the reference receivers and
processors in existing LAAS prototypes.
This paper focuses on interference direction finding us-ing
interferometry. Given an undesired interference sig-nal,
measuring the signal propagation delay along the base-line
between two antennas is used to estimate the direction
of the signal. Measurements from the multiple baselines
present in the LAAS Ground Facility are combined to esti-mate
the location of the undesired signal transmitter.
The paper describes the Stanford Prototype IDF receiver
design and presents experimental results that demonstrate
the use of the IDF to detect nominal GPS signals and deter-mine
the source of interfering signals.
6F-1 Trench-Isolated CMUT Arrays with a Supporting Frame: Characterization and Imaging Results (2007)

We report on the characterization and imaging results of trench-isolated CMUT arrays with a supporting frame. The CMUT arrays are built on a silicon-on-insulator (SOI) wafer using direct wafer-to-wafer fusion bonding technique. Electrical contacts to individual elements are brought to the back side of the wafer by highly conductive silicon pillars. Mechanical support for array elements is provided by a silicon frame structure. 1D and 2D arrays with 250-mum element pitch were fabricated and tested in air and in immersion. Rectangular membranes are used, which feature two distinctive pull-in (collapse) points in both air and immersion tests. The double collapsing membranes enable an operating frequency ranging from 1.9 MHz in conventional mode to 58 MHz in second collapse mode on the same device. After flip-chip bonding the 2D arrays to custom-designed integrated circuits (IC), volumetric imaging was demonstrated.
Supplementary Table 1 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice (2023)

&lt;p&gt;XLSX file - 125K, Drugs with 40-100% inhibition.&lt;/p&gt;
The Windowed Removable Partial Denture: A Treatment Option for Patients with Lone-Standing Teeth. (2015)

The decision as to whether to retain or extract a single remaining natural tooth prior to the provision of dentures can be a difficult one. If the tooth is left in situ, the development of an adequate peripheral seal around the denture is not possible thereby compromising the appliance' retention. If the tooth is extracted the possibility of gaining direct retention with the use of clasps or attachments is lost. This paper aims to illustrate the use of windowed removable partial denture design and review the literature relevant to this area. The use of such a design can enhance the retention of the appliance by encircling the lone standing tooth/teeth utilising an elastomeric permanent soft lining material.
Servo control with a flat glass tilt in pickup actuator for holographic data storage (2003)

In order to read out correct data from a disk-type holographic storage system, it is very important to implement a servo control in pickup modules, like as in conventional CD-ROM and DVD-ROM. We propose a novel servo-control method by use of a glass-plate on optical axis, which is able to compensate readout errors mainly coming from mechanical wobbling of the holographic disk. By rotating the glass-plate within &plusmn; 10 degrees, we can reduce the readout position-errors of &plusmn; 200 &mu;m to &plusmn; 15 &mu;m.
Modernity and obesity in coastal and Highland Papua New Guinea. (1995)

Aspects of modernity, such as more sophisticated housing and greater number of years spent in an urban centre, may be markers of higher income and increasing adoption of Western ways, which in turn are associated with physical inactivity and increased availability of energy-dense Western food, thus promoting obesity in this rapidly developing Pacific nation.
On Improving Summarization Factual Consistency from Natural Language Feedback (2023)

Yixin Liu, Budhaditya Deb, Milagro Teruel, Aaron Halfaker, Dragomir Radev, Ahmed Hassan Awadallah. Proceedings of the 61st Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers). 2023.
Utility-based bandwidth adaptation in mission-oriented wireless sensor networks (2012)

This article develops a utility-based optimization framework for resource sharing by multiple competing missions in a mission-oriented wireless sensor network (WSN) environment. Prior work on network utility maximization (NUM) based optimization has focused on unicast flows with sender-based utilities in either wireline or wireless networks. In this work, we develop a generalized NUM model to consider three key new features observed in mission-centric WSN environments: i) the definition of the utility of an individual mission (receiver) as a joint function of data from multiple sensor sources; ii) the consumption of each sender's (sensor) data by multiple missions; and iii) the multicast-tree-based dissemination of each sensor's data flow, using link-layer broadcasts to exploit the “wireless broadcast advantage” in data forwarding. We show how a price-based, distributed protocol (WSN-NUM) can ensure optimal and proportionally fair rate allocation across multiple missions, without requiring any coordination among missions or sensors. We also discuss techniques to improve the speed of convergence of the protocol, which is essential in an environment as dynamic as the WSN. Further, we analyze the impact of various network and protocol parameters on the bandwidth utilization of the network, using a discrete-event simulation of a stationary wireless network. Finally, we corroborate our simulation-based performance results of the WSN-NUM protocol with an implementation of an 802.11b network.
Influence of Renal Impairment on the Success of Reconstruction Using Microvascular Grafts—A Retrospective Study of 251 Free Flaps (2022)

A preoperative value indicative of impaired renal function, such as creatinine levels, GFR, or electrolytes, did not prove to be an individual risk factor for the occurrence of graft failure in this patient population. Nevertheless, increased renal parameters are associated with increased incidence of serious complications. Therefore, these should be considered in the indication and preoperative planning.
Surface Functionalization of Porous Nanostructured Metal Oxide Thin Films Fabricated by Glancing Angle Deposition (2006)

We report the application of solution- and vapor-phase siloxane-based methods for tailoring the surface chemistry/properties of highly porous, nanostructured thin films fabricated using glancing angle deposition (GLAD). The GLAD technique produces high surface area films consisting of isolated columns and provides complete control over the film/column morphology. In the present study, the chemical tunability of a variety of metal oxide GLAD films was investigated using solution-based and vapor-phase surface functionalization methodologies. The surface properties and structures of the treated and untreated films were investigated using scanning electron microscopy (SEM), advancing aqueous contact angle measurements, cyclic voltammetry, and X-ray photoelectron spectroscopy (XPS). Results indicate that the surface chemistry of metal oxide GLAD films could be tailored by either method; however, chemical reactivity depends strongly on the metal oxide film material. Chemical tunability is demonstrated through the covalent tethering of numerous chemical moieties onto the exposed and interior surfaces of metal oxide GLAD films of varied structural motifs. Through careful choice of surface modifier, the present derivatization methods afford a full range of aqueous wettability from hydrophilic to superhydrophobic without compromising film structure. These functionalized, nanoconstructed films demonstrate a high degree of tunability over both structural and surface properties, making them well suited for diverse applications such as optical filters or sensors.
Variation of Influenza A, B, and C Viruses (1982)

Influenza is caused by highly variable RNA viruses belonging to the orthomyxovirus group. These viruses are capable of constantly changing the genes coding for their surface proteins as well as for their nonsurface proteins. The mechanisms responsible for these changes in type A influenza viruses include recombination (reassortment) of genes among strains, deletions and insertions in genes, and, frequently, point mutations. In addition, old strains may reappear in the population. Influenza viruses of types B and C appear to vary to a lesser degree. The mechanisms responsible for changes in these viruses are not well characterized.
Effect of condenser tilt on projection images produced by a phase-shifting mask (1992)

The effects of condenser tilt on the imaging characteristics of optical projection exposure systems for lithography are investigated analytically and experimentally. For the focus dependence of images, the difference between a phase-shifting mask and a conventional transmission mask is examined. Condenser tilt effects are explored by displacing the source images formed on the entrance pupil of a projection lens. Condenser tilt is shown to shift periodic line pattern images when the image plane is out of focus. For fine features near the resolution limit of the projection lens, the direction of image shift that occurs with a phase- shifting mask is shown to be opposite the shift that occurs with a transmission mask. For fine features, condenser tilt is also shown to diminish the image contrast obtained with phase-shifting mask and increase the contrast obtained with transmission mask.
Main chain decomposable star shaped polymer for EUV resist (2009)

The Extreme Ultra Violet lithography (EUVL) is expected to be the most promising semiconductor fabrication technology for 22 nm node and beyond. Kozawa and his colleagues have documented that non-constant acid diffusion coefficient have a significant impact on the latent image quality of 22 nm patterns. We prepared a novel main chain decomposable star shaped polymer (STAR polymer) to examine the concept. STAR polymer consists of a core unit and several arm units which connect to the core unit as shown in Fig.1. The arm units are partially protected poly (<i>p</i>-hydroxystyrene) (PHS) base linear polymer. The core unit that attached on the arm units employs easily acid cleavable group. The adoption of living anion polymerization for the arm units of the STAR polymer makes the controlled polymerization of one monomer unit possible. Based on this material design concept, the protecting group on the arm unit is de-protected by the acid generated during exposure and continues its reaction at the Post Exposure Bake (PEB) step and the acid will also cleave the bonding of the core unit which would then result in a lower molecular weight polymer of lower <i>T</i><i><sub>g</sub></i>. The concept of the novel polymer, which is the decomposition of the core and protecting group of arm units of the STAR polymer, was confirmed with a gel-permeation-chromatography (GPC) study. The thermal property of the exposed and unexposed area was also investigated through a thermal flow method. The <i>T</i><i><sub>g</sub></i> decrease of the exposed area was observed with the STAR polymer, regardless of increase in <i>T</i><i><sub>g</sub></i> of the linear polymer. General lithographic performance on EUV exposure for STAR polymer was also discussed.