gebhart/patrepeval huggingface dataset:
Dynamic visual motion estimation from subspace constraints (2002)

The problem of estimating rigid motion from projections may be characterized using a nonlinear dynamical system, composed of the rigid motion constraint and the perspective map. The time derivative of the output of such a system, which is called the "motion field" and approximated by the "optical flow", is bilinear in the motion parameters, and may be used to specify a subspace constraint on either the direction of translation or the inverse depth of the observed points. Estimating motion may then be formulated as an optimization task constrained on such a subspace. We pose the optimization problem in a system theoretic framework as the the identification of a nonlinear implicit dynamical system with parameters on a differentiable manifold, and use techniques which pertain to nonlinear estimation and identification theory to perform the optimization task in a principled manner. The application of a general method presented in by Soatto et al. (see 33rd. IEEE conf. on Decision and Control, 1994) results in a recursive and pseudo-optimal solution of the visual motion estimation problem, which has robustness properties far superior to other existing techniques we have implemented. Experiments on real and synthetic image sequences show very promising results in terms of robustness, accuracy and computational efficiency.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Thermally stable, low-resistance PdGe-based ohmic contacts to high–low doped n-GaAs (1995)

Thermally stable, low-resistance PdGe-based ohmic contacts to high–low doped n-GaAs have been developed. The lowest contact resistance obtained is two times lower than that of previously reported PdGe ohmic contacts. The contacts are thermally stable even after isothermal annealing for 5 h at 400 °C under atmosphere ambient. X-ray diffraction results and Auger depth profiles show that the good PdGe-based ohmic contact is due to the formation of both AuGa and TiO compounds. The AuGa compound enhances the creation of more Ga vacancies, followed by the incorporation of Ge into Ga vacancies, and the TiO compound suppresses As outdiffusion from the GaAs substrate, respectively.
Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits (2019)

Ibogaine is an atypical psychedelic alkaloid, which has been subject of research due to its reported ability to attenuate drug-seeking behavior. Recent work has suggested that ibogaine effects on alcohol self-administration in rats are related to the release of Glial cell Derived Neurotrophic Factor (GDNF) in the Ventral Tegmental Area (VTA), a mesencephalic region which hosts the soma of dopaminergic neurons. Although previous reports have shown ibogaine's ability to induce GDNF expression in rat midbrain, there are no studies addressing its effect on the expression of GDNF and other neurotrophic factors (NFs) such as Brain Derived Neurotrophic Factor (BDNF) or Nerve Growth Factor (NGF) in distinct brain regions containing dopaminergic neurons. In this work, we examined the effect of ibogaine acute administration on the expression of these NFs in the VTA, Prefrontal Cortex (PFC), Nucleus Accumbens (NAcc) and the Substantia Nigra (SN). Rats were i.p. treated with ibogaine 20 mg/kg (I<sub>20</sub>), 40 mg/kg (I<sub>40</sub>) or vehicle, and NFs expression was analyzed after 3 and 24 h. At 24 h an increase of the expression of the NFs transcripts was observed in a site and dose dependent manner. Only for I<sub>40</sub>, GDNF was selectively upregulated in the VTA and SN. Both doses elicited a large increase in the expression of BDNF transcripts in the NAcc, SN and PFC, while in the VTA a significant effect was found only for I<sub>40</sub>. Finally, NGF mRNA was upregulated in all regions after I<sub>40</sub>, while I<sub>20</sub> showed a selective upregulation in PFC and VTA. Regarding protein levels, an increase of GDNF was observed in the VTA only for I<sub>40</sub> but no significant increase for BDNF was found in all the studied areas. Interestingly, an increase of proBDNF was detected in the NAcc for both doses. These results show for the first time a selective increase of GDNF specifically in the VTA for I<sub>40</sub> but not for I<sub>20</sub> after 24 h of administration, which agrees with the effective dose found in previous self-administration studies in rodents. Further research is needed to understand the contribution of these changes to ibogaine's ability to attenuate drug-seeking behavior.
The upregulation of the inhibitory receptors BTLA and PD-1 defines a novel subset of dysfunctional tumor antigen-specific CD8+ T cells (127.19) (2012)

Abstract Cytotoxic T cells present at the periphery or at tumor sites recognize tumor epitopes presented by melanoma cells but fail to induce tumor rejection in melanoma patients. Inhibitory receptors including PD-1 and Tim-3 expressed by spontaneous CD8+ T cells directed against the cancer-germline antigen NY-ESO-1 play a role in promoting tumor-induced T cell dysfunction. In the present study, we show that BTLA is upregulated on spontaneous NY-ESO-1-specific CD8+ T cells and that BTLA-expressing PD-1+Tim-3- CD8+ T cells represent the largest subset of NY-ESO-1-specific CD8+ T cells in melanoma patients. These cells were partially dysfunctional, producing less IFN-γ than BTLA- T cells, but more IFN-γ, TNF and IL-2 than the highly dysfunctional subset expressing all three receptors. Unlike PD-1, BTLA expression by NY-ESO-1-specific CD8+ T cells does not increase with higher T cell dysfunction or upon cognate antigen stimulation, suggesting that BTLA upregulation occurs independently of functional exhaustion driven by high antigen load. Finally, BTLA blockade adds to PD-1 and Tim-3 blockades, enhancing NY-ESO-1-specific CD8+ T cell expansion, proliferation and cytokine production. Collectively, our findings support the targeting of BTLA, PD-1 and Tim-3 pathways to reverse tumor-induced T cell dysfunction in patients with advanced melanoma.
Marked Alkyl- vs Alkenyl-Substitutent Effects on Squaraine Dye Solid-State Structure, Carrier Mobility, and Bulk-Heterojunction Solar Cell Efficiency (2010)

We report two new squaraine dyes substituted at the pyrrolic rings with n-hexyl (squaraine 1) or n-hexenyl (squaraine 2) chains. Although internal molecular structure variations are minimal, the presence of the terminal double bond results in a much more compact solid-state structure, dramatically affecting charge transport in the thin films; the hole mobility of 2 is approximately 5x that of 1, and the BHJ OPV power conversion efficiency (PCE) of 2 is approximately 2x that of 1. PCEs surpassing 2% for ambient solution-processed devices are demonstrated, the largest so far achieved for squaraine-based organic solar cells.
New tools for the control of peptide conformation: the helicogenic Cα‐methyl, Cα‐cyclohexylglycine* (2004)

The novel Calpha-tetrasubstituted alpha-amino acid Calpha-methyl, Calpha-cyclohexylglycine was prepared by hydrogenation of its Calpha-methyl, Calpha-phenylglycine precursor. Terminally protected homodi-, homotri-, and homotetrapeptides from Calpha-methyl, Calpha-cyclohexylglycine and co-oligopeptides to the pentamer level in combination with Gly or alpha-aminoisobutyric acid residues were prepared by solution methods and fully characterized. The results of a conformational analysis, performed by use of Fourier transform infrared (FT-IR) spectrophotometer absorption, 1H NMR, and X-ray diffraction techniques, support the contention that this Calpha-methylated, Cbeta-trisubstituted aliphatic alpha-amino acid is an effective beta-turn and 3(10)-helix inducer in tri- and longer peptides as its Calpha-methyl valine parent compound, but partially divergent from the corresponding aromatic Calpha-methyl, Calpha-diphenylmethylglycine residue, known to promote folded and fully extended structures to a significant extent in these oligomers.
ChemInform Abstract: Synthesis of (.+‐.)‐Oxohexahydrofuro[3,2‐b]pyrroles (Pyrrolidine‐trans‐lactones) via a Reduction—Alkylation Protocol. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Quantitative Imaging of Cell-Permeable Magnetic Resonance Contrast Agents Using X-Ray Fluorescence (2006)

The inability to transduce cellular membranes is a limitation of current magnetic resonance imaging probes used in biologic and clinical settings. This constraint confines contrast agents to extracellular and vascular regions of the body, drastically reducing their viability for investigating processes and cycles in developmental biology. Conversely, a contrast agent with the ability to permeate cell membranes could be used in visualizing cell patterning, cell fate mapping, gene therapy, and, eventually, noninvasive cancer diagnosis. Therefore, we describe the synthesis and quantitative imaging of four contrast agents with the capability to cross cell membranes in sufficient quantity for detection. Each agent is based on the conjugation of a Gd(III) chelator with a cellular transduction moiety. Specifically, we coupled Gd(III)-diethylenetriaminepentaacetic acid DTPA and Gd(III)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid with an 8-amino acid polyarginine oligomer and an amphipathic stilbene molecule, 4-amino-4'-(N,N-dimethylamino)stilbene. The imaging modality that provided the best sensitivity and spatial resolution for direct detection of the contrast agents is synchrotron radiation x-ray fluorescence (SR-XRF). Unlike optical microscopy, SR-XRF provides two-dimensional images with resolution 10(3) better than (153)Gd gamma counting, without altering the agent by organic fluorophore conjugation. The transduction efficiency of the intracellular agents was evaluated by T(1) analysis and inductively coupled plasma mass spectrometry to determine the efficacy of each chelate-transporter combination.
Randomized double-blind placebo-controlled Trial of Perhexiline in Heart Failure With Preserved Ejection Fraction Syndrome (2014)

Recently heart failure with preserved ejection fraction (HFpEF) has emerged as a huge epidemic. Increasing evidence shows the role of energy deficiency in the pathophysiology of HFpEF. In the current study, we hypothesize that the use of metabolic modulator perhexiline would correct myocardial energy deficiency and improve exercise capacity and diastolic abnormalities in patients with this syndrome.
Hexameric MnII Dendrimer as MRI Contrast Agent (2014)

A Mn(II) chelating dendrimer was prepared as a contrast agent for MRI applications. The dendrimer comprises six tyrosine-derived [Mn(EDTA)(H2 O)](2-) moieties coupled to a cyclotriphosphazene core. Variable temperature (17) O NMR spectroscopy revealed a single water co-ligand per Mn(II) that undergoes fast water exchange (kex =(3.0±0.1)×10(8) s(-1) at 37 °C). The 37 °C per Mn(II) relaxivity ranged from 8.2 to 3.8 mM(-1) s(-1) from 0.47 to 11.7 T, and is sixfold higher on a per molecule basis. From this field dependence a rotational correlation time was estimated as 0.45(±0.02) ns. The imaging and pharmacokinetic properties of the dendrimer were compared to clinically used [Gd(DTPA)(H2 O)](2-) in mice at 4.7 T. On first pass, the higher per ion relaxivity of the dendrimer resulted in twofold greater blood signal than for [Gd(DTPA)(H2 O)](2-) . Blood clearance was fast and elimination occurred through both the renal and hepatobiliary routes. This Mn(II) containing dendrimer represents a potential alternative to Gd-based contrast agents, especially in patients with chronic kidney disease where the use of current Gd-based agents may be contraindicated.
Prefrontal cortex modulates posterior alpha oscillations during top-down guided visual perception (2017)

Conscious visual perception is proposed to arise from the selective synchronization of functionally specialized but widely distributed cortical areas. It has been suggested that different frequency bands index distinct canonical computations. Here, we probed visual perception on a fine-grained temporal scale to study the oscillatory dynamics supporting prefrontal-dependent sensory processing. We tested whether a predictive context that was embedded in a rapid visual stream modulated the perception of a subsequent near-threshold target. The rapid stream was presented either rhythmically at 10 Hz, to entrain parietooccipital alpha oscillations, or arrhythmically. We identified a 2- to 4-Hz delta signature that modulated posterior alpha activity and behavior during predictive trials. Importantly, delta-mediated top-down control diminished the behavioral effects of bottom-up alpha entrainment. Simultaneous source-reconstructed EEG and cross-frequency directionality analyses revealed that this delta activity originated from prefrontal areas and modulated posterior alpha power. Taken together, this study presents converging behavioral and electrophysiological evidence for frontal delta-mediated top-down control of posterior alpha activity, selectively facilitating visual perception.
Loudspeaker Equalization with Post-Processing (2002)

Loudspeaker equalization is an essential technique in audio system design. A well-known equalization scheme is based on the deconvolution of the desired equalized response with the measured impulse response of the loudspeaker. In this paper, a post-processing scheme is combined with the deconvolution-based algorithm to provide a better equalization effect. Computer simulation results are given to demonstrate the significant improvement that can be achieved using this method.
An MCBJ case study: The influence of π-conjugation on the single-molecule conductance at a solid/liquid interface (2011)

π-Conjugation plays an important role in charge transport through single molecular junctions. We describe in this paper the construction of a mechanically controlled break-junction setup (MCBJ) equipped with a highly sensitive log I-V converter in order to measure ultralow conductances of molecular rods trapped between two gold leads. The current resolution of the setup reaches down to 10 fA. We report single-molecule conductance measurements of an anthracene-based linearly conjugated molecule (AC), of an anthraquinone-based cross-conjugated molecule (AQ), and of a dihydroanthracene-based molecule (AH) with a broken conjugation. The quantitative analysis of complementary current-distance and current-voltage measurements revealed details of the influence of π-conjugation on the single-molecule conductance.
Clinical and Nephrologic Tolerance of Iopromide and Iotrolan in Computed Tomography (1991)

LANGER, M. MD; LANGER, R. MD; ZWICKER, C. MD; SPECK, U.; JÄNICKE, U.-A. MD; FELIX, R. MD Author Information
Triacetonide of Glucoheptonic Acid in the Scalable Syntheses of d-Gulose, 6-Deoxy-d-gulose, l-Glucose, 6-Deoxy-l-glucose, and Related Sugars (2016)

Ease of separation of petrol-soluble acetonides derived from the triacetonide of methyl glucoheptonate allows scalable syntheses of rare sugars containing the l-gluco or d-gulo structural motif with any oxidation level at the C6 or C1 position of the hexose, usually without chromatography: meso-d-glycero-d-guloheptitol available in two steps is an ideal entry point for the study of the biotechnological production of heptoses.
Molecular atlas of the human brain vasculature at the single-cell level (2021)

A broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading cause of death worldwide. However, the cellular and molecular architecture of the human brain vasculature remains poorly understood. Here, we performed single-cell RNA sequencing of 599,215 freshly isolated endothelial, perivascular and other tissue-derived cells from 47 fetuses and adult patients to construct a molecular atlas of the developing fetal, adult control and diseased human brain vasculature. We uncover extensive molecular heterogeneity of healthy fetal and adult human brains and across eight vascular-dependent CNS pathologies including brain tumors and brain vascular malformations. We identify alteration of arteriovenous differentiation and reactivated fetal as well as conserved dysregulated pathways in the diseased vasculature. Pathological endothelial cells display a loss of CNS-specific properties and reveal an upregulation of MHC class II molecules, indicating atypical features of CNS endothelial cells. Cell-cell interaction analyses predict numerous endothelial-to-perivascular cell ligand-receptor crosstalk including immune-related and angiogenic pathways, thereby unraveling a central role for the endothelium within brain neurovascular unit signaling networks. Our single-cell brain atlas provides insight into the molecular architecture and heterogeneity of the developing, adult/control and diseased human brain vasculature and serves as a powerful reference for future studies.
Incorporating the Single-Loop Delta-Sigma Modulator in Fractional-N Frequency Synthesizer for Phase-Noise Improvement (2006)

This research experimentally evaluates the improvement of phase noise in a fractional-N frequency synthesizer that uses the single-loop delta-sigma modulator (DSM) instead of the conventional multi-stage noise-shaping (MASH) DSM. The single-loop DSM can achieve a smaller range of quantization levels so as to be much less susceptible to the phase-locked loop (PLL) nonlinearity than the MASH DSM. The advantage is to effectively suppress the growth of quantization noise spectrum due to the PLL nonlinearity, resulting in low phase noise for the fractional-N frequency synthesizer. The experimental results show that a 4th order single-loop DSM design can improve the phase noise of fractional-N frequency synthesizer by 28 dB within the PLL bandwidth when used to replace the same order MASH DSM design
Improvement of gadoxetate arterial phase capture with a high spatio‐temporal resolution multiphase three‐dimensional SPGR‐dixon sequence (2013)

The high STR multiphase acquisition resulted in more reliable gadoxetate arterial phase capture compared with a conventional acquisition while preserving image quality with robust fat saturation.
Seroevidence for H5N1 Influenza Infections in Humans: Meta-Analysis (2012)

The prevalence of avian H5N1 influenza A infections in humans has not been definitively determined. Cases of H5N1 infection in humans confirmed by the World Health Organization (WHO) are fewer than 600 in number, with an overall case fatality rate of >50%. We hypothesize that the stringent criteria for confirmation of a human case of H5N1 by WHO do not account for a majority of infections but rather the select few hospitalized cases that are more likely to be severe and result in poor clinical outcome. Meta-analysis shows that 1 to 2% of more than 12,500 study participants from 20 studies had seroevidence for prior H5N1 infection.
Energetics of Technical Integration of 2‐Propanol Fuel Cells: Thermodynamic and Current and Future Technical Feasibility (2022)

2‐Propanol/acetone is a promising liquid organic hydrogen carrier system for fuel cell reactions. Herein, six different concepts for a 2‐propanol/acetone fuel cell system are evaluated in MATLAB simulation with respect to their thermodynamic integration and technical feasibility. Four of the concepts use a direct 2‐propanol fuel cell while the other two first release molecular hydrogen from 2‐propanol and subsequently use a hydrogen fuel cell. The presented liquid phase 2‐propanol fuel cell concept is thermodynamically feasible but cannot be realized technically using commercial Nafion membranes, due to membrane dissolution by the 2‐propanol/acetone/water fuel mixture. Gaseous 2‐propanol fuel cells imply a high heating requirement for the evaporation of the fuel. A direct high‐temperature fuel cell using 2‐propanol is thermodynamically feasible because there is less water in the overall system but is not technically feasible because of the esterification of phosphoric acid. A very interesting option is the conversion of gaseous 2‐propanol to pressurized hydrogen in an electrochemical pumping step followed by a hydrogen fuel cell, because here the waste heat of a sufficiently hot hydrogen fuel cell can drive the 2‐propanol evaporation.
Metal Concentrations in the Serum and Hair of Patients With Titanium Alloy Spinal Implants (2003)

Approximately one third of patients with titanium alloy spinal implants exhibited abnormal serum or hair metal concentrations at a mean time of mean 5.1 years after surgery. Titanium or aluminum may travel to distant organs after dissolution of metals from the spinal implants.
Gene Expression Analysis of Photoreceptor Cell Loss inBbs4-Knockout Mice Reveals an Early Stress Gene Response and Photoreceptor Cell Damage (2007)

The specific loss of photoreceptors in Bbs4(-)(/)(-) mice allows us to identify a set of genes that are preferentially expressed in photoreceptors compared with other cell types found in the eye and is a valuable resource in the continuing search for genes involved in retinal disease. The molecular and morphologic changes observed in young BBS animal model eyes implies that BBS proteins play a critical, early role in establishing the correct structure and function of photoreceptors.
Evaluating the Effects of Different Skin Products on the in vivo THz Response of Skin (2020)

Terahertz (THz) imaging is the focus of research regarding a growing number of biomedical applications. In this study the ability of in vivo THz measurements to distinguish the different effects of three commercial skin products composed of water, oil and a water-oil emulsion is investigated. It can be seen that some samples are received in a uniform way by many skin types while others show a broad range of responses.
Policy Schedule Advisor for Performance Management (2005)

Policies are being increasingly used as a means of implementing autonomic computing features in IT systems. Since these policies consume system resources, the performance of a policy-based system may be hampered if resource intensive policies are scheduled at the same time when other policies and applications are being executed. However, with applications being accessed by users globally across time zones, and fast changing business needs, it is increasingly difficult to identify and maintain suitable schedules for these policies. In this paper we propose a framework to address the above aspect of the policy-based autonomic computing - the problem of determining when to schedule a given policy such that its impact on system performance is minimized, and then giving appropriate feedback. This feedback is aimed at assisting the policy maker in defining or redefining the policy schedule so that it can be executed more efficiently. In this framework, we make use of the underlying log data (i.e. resource utilization data) of a managed resource in order to determine an appropriate policy schedule. We demonstrate the efficacy of our approach using DB2 as a managed resource and policies for data management