gebhart/patrepeval huggingface dataset:
Probing Backbone Hydrogen Bonds in Proteins by Amide‐to‐Ester Mutations (2018)

All proteins contain characteristic backbones formed of consecutive amide bonds, which can engage in hydrogen bonds. However, the importance of these is not easily addressed by conventional technologies that only allow for side-chain substitutions. By contrast, technologies such as nonsense suppression mutagenesis and protein ligation allow for manipulation of the protein backbone. In particular, replacing the backbone amide groups with ester groups, that is, amide-to-ester mutations, is a powerful tool to examine backbone-mediated hydrogen bonds. In this minireview, we showcase examples of how amide-to-ester mutations can be used to uncover pivotal roles of backbone-mediated hydrogen bonds in protein recognition, folding, function, and structure.
Back Cover: Fast piezoresistive sensor and UV photodetector based on Mn-doped ZnO nanorods (Phys. Status Solidi RRL 1/2015) (2015)

No abstract is available for this article.
[Acute poisoning with sertindole--a case report]. (2013)

The paper presents a case of acute, accidental sertindole poisoning. Intoxication had a stormy clinical course with symptoms of cardiovascular, respiratory and nervous system. A relatively small dose of ingested preparation and severe overdose course may indicate a low therapeutic drug index.
ChemInform Abstract: Proton‐Loaded Zeolites. Part 1. HX (X: Cl, Br, I) in Sodium Zeolite Y Archetype: Packaged Acids on the Road to Intrazeolite Semiconductors (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effects of Bottom Electrodes (Pt and IrO2) on Physical and Electrical Properties of Bi4-xLaxTi3O12 Thin Film (2001)

Negated Bi 3.35 La 0.85 Ti 3 O 12 (BLT) thin (90 nm) films were prepared on Pt (200 nm) and IrO 2 (200 nm) electrodes by metalorganic decomposition (MOD) method, and crystallized by rapid thermal annealing (RTA) and the subsequent furnace annealing. BLT films were c -axis oriented on both electrodes irrespective of RTA temperature (600 and 700°C). However, the degree of c -axis orientation was much higher on IrO 2 than on Pt, and significantly reduced only on Pt with decreasing RTA temperature. This result was related to the different stress of BLT film which is negligible on Pt, but 500 MPa (tensile) on IrO 2 in the RTA temperature range of 600–700°C. The crystalline orientation of BLT film directly affected switching polarization ( P * - P ∧ ) which had much smaller value of 5 µC/cm 2 on IrO 2 than 12 µC/cm 2 on Pt, and was increased to 16 µC/cm 2 only on Pt with the decrease of RTA temperature. On the other hand, leakage characteristics were not changed with bottom electrode materials.
Diamondlike Carbon For Infrared Optics (1989)

Diamondlike Carbon (DLC), also known as amorphous hydrogenated carbon (or a:C-H), is a hard semitransparent material. Since it is amorphous and has no grain boundaries, it is proposed for use as a coating on infrared optical surfaces to protect them from the envi-ronmentally adverse chemicals such as the acids, salt water, etc., as well as particle impact. Moisture penetration studies of DLC, usicgthe Variable Angle Spectroscopic Ellipsometry (VASE), have been presented elsewhere 194&apos;. In this paper, we first briefly mention sample preparation, done using various combinations of RF power and gas pressure in a plasma deposition chamber. Then, results of using an ultraviolet-visible (UV-VIS) absorbance spectrometer are presented. From the absorbance we calculated the band gap using the Tauc plots, and found values ranging from 0.2 to 1.25eV, depending on deposition condition. Secondly, a series of DLC samples were prepared using a Kaufman type ion beam deposition system. Using VASE, we have studied these samples after bombarding them with various fluences of Fl, and analyzed the data using two Lorentz oscillators to represent the optical properties. We have also shown the correlation between the optical properties and the amount of hydrogen present within the samples, as measured by proton recoil experiments.
LCM (1994)

Higher-level parallel programming languages can be difficult to implement efficiently on parallel machines. This paper shows how a flexible, compiler-controlled memory system can help achieve good performance for language constructs that previously appeared too costly to be practical.
Robust Control Based on Disturbance Observer and Polynomial Coefficient Approach for Mechanical System (1998)

This paper proposes a new robust speed control system based on disturbance observer and coprime factorization for mechanical systems. The proposed system takes account of large variation of inertia ratio. It has the two loop systems. The inner loop system is the state feedback and the state observer system, which is designed by coprime factorization. In this paper, the poles and parameter variation effect of inner loop system are newly determined by using the polynomial coefficient approach. The outer loop system based on disturbance observer satisfies the robust stability condition on parameter variation. The reference response easily defines the desired transfer function from the speed reference to the load speed. The numerical simulation results show that the proposed system well regulates the load speed and suppresses the torsional vibration phenomena.
Randomized, placebo‐controlled, phase 3 study of perifosine combined with bortezomib and dexamethasone in patients with relapsed, refractory multiple myeloma previously treated with bortezomib (2020)

Perifosine, an investigational, oral, synthetic alkylphospholipid, inhibits signal transduction pathways of relevance in multiple myeloma (MM) including PI3K/Akt. Perifosine demonstrated anti-MM activity in preclinical studies and encouraging early-phase clinical activity in combination with bortezomib. A randomized, double-blind, placebo-controlled phase 3 study was conducted to evaluate addition of perifosine to bortezomib-dexamethasone in MM patients with one to four prior therapies who had relapsed following previous bortezomib-based therapy. The primary endpoint was progression-free survival (PFS). The study was discontinued at planned interim analysis, with 135 patients enrolled. Median PFS was 22.7 weeks (95% confidence interval 16·0-45·4) in the perifosine arm and 39.0 weeks (18.3-50.1) in the placebo arm (hazard ratio 1.269 [0.817-1.969]; <i>P</i> = .287); overall response rates were 20% and 27%, respectively. Conversely, median overall survival (OS) was 141.9 weeks and 83.3 weeks (hazard ratio 0.734 [0.380-1.419]; <i>P</i> = .356). Overall, 61% and 55% of patients in the perifosine and placebo arms reported grade 3/4 adverse events, including thrombocytopenia (26% vs 14%), anemia (7% vs 8%), hyponatremia (6% vs 8%), and pneumonia (9% vs 3%). These findings demonstrate no PFS benefit from the addition of perifosine to bortezomib-dexamethasone in this study of relapsed/refractory MM, but comparable safety and OS.
Simulation and Visualization of Room Compensation for Wave Field Synthesis with the Functional Transformation Method (2005)

This convention paper has been reproduced from the author’s advance manuscript, without editing, corrections, or consideration by the Review Board. The AES takes no responsibility for the contents. Additional papers may be
A tale of two moduli spaces: logarithmic and multi-scale differentials (2022)

Multi-scale differentials were constructed by M.~Bainbridge, D.~Chen, Q.~Gendron, S.~Grushevsky, and M.~Möller, from the viewpoint of flat and complex geometry, for the purpose of compactifying moduli spaces of curves together with a differential with prescribed orders of zeros and poles. Logarithmic differentials were constructed by S.~Marcus and J.~Wise, as a generalization of stable rubber maps from Gromov--Witten theory. Modulo the global residue condition that isolates the main components of the compactification, we show that these two kinds of differentials are equivalent, and establish an isomorphism of their (coarse) moduli stacks. Moreover, we describe the rubber and multi-scale spaces as an explicit blowup of the moduli space of stable pointed rational curves in the case of genus zero, and as a global blowup of the incidence variety compactification for arbitrary genera, which implies their projectivity. We also propose a refined double ramification cycle formula in the twisted Hodge bundle which interacts with the universal line bundle class.
Object recognition based on structural description of images in three-dimensional space (2018)

A method for object recognition based on the use of a structural description of images of three-dimensional scenes is proposed, and it is experimentally compared with existing analogues. A quantitative assessment of the recognition accuracy and speed of the studied methods is presented. Methods for detecting key points and building image descriptors in three-dimensional space are studied. The algorithm developed here can be used to address issues with mobile robot and unmanned aerial vehicle navigation under the conditions characterized by a high degree of a priori uncertainty of the scene.
Image Compression Terrain Simplification (2007)

Abstract. Surface simplification is an important application in geographic information systems. The goal is to obtain a new surface that is combinatorially as simple as possible, while maintaining a prescribed degree of similarity with the original input surface. In this paper, we propose a new terrain simplification algorithm which is based on known Digital Image Processing compression methods (e.g. DCT, wavelets compression) that was specially adjusted to fit Digital Elevation Models. DEM-images are terrains or elevation maps represented as gray scale images. We investigate the special nature of such terrain-images and design a unique pre-compression process which defines the parameters to guide the image compression. We perform a large-scale experiment comparing several terrain simplification methods and conclude that the new suggested algorithm (named ICTS 1) leads to significantly better compression results. 1
To Link or Not to Link? A Study on End-to-End Tweet Entity Linking (2013)

Information extraction from microblog posts is an important task, as today microblogs capture an unprecedented amount of information and provide a view into the pulse of the world. As the core component of information extraction, we consider the task of Twitter entity linking in this paper. In the current entity linking literature, mention detection and entity disambiguation are frequently cast as equally important but distinct problems. However, in our task, we find that mention detection is often the performance bottleneck. The reason is that messages on micro-blogs are short, noisy and informal texts with little context, and often contain phrases with ambiguous meanings. To rigorously address the Twitter entity linking problem, we propose a structural SVM algorithm for entity linking that jointly optimizes mention detection and entity disambiguation as a single end-to-end task. By combining structural learning and a variety of firstorder, second-order, and context-sensitive features, our system is able to outperform existing state-of-the art entity linking systems by 15 % F1. 1
On Application of the Partition Distance Concept to a Comparative Analysis of Psychological or Sociological Tests (2006)

Abstract We discuss two distance concepts between q-ary n-sequences, 2 ≤ q < n, called partition distances. This distances are metrics in the space of all partitions of a finite n-set. For the metrics, we study codes called q-partition codes and present a construction of these codes based on the first order Reed–Muller codes. A random coding bound is obtained. We also work out an application of q-partition codes to the statistical analysis of psychological or medical tests using questionnaires.
THE DISTRIBUTION OF ACIDIC AND ESTERIFIED PECTIN IN CAMBIUM, DEVELOPING XYLEM AND MATURE XYLEM OF PINUS SYLVESTRIS (2000)

Homogalacturonans with low and high degree of methyl esterification have been immuno-localised in the cambium, differentiating xylem and mature xylem of Pinus sylvestris , by monoclonal antibodies JIM5 and JIM7. In the unlignified cambial tissue the antibodies revealed a similar distribution for acidic and esterified pectin in the compound middle lamella, ray cell walls and pit membranes. In the lignified xylem tissue, pectin was also found in the compound middle lamella, although dominantly in the methylesterified form. Lignification seemed to coincide with a decrease in the presence of acidic pectin in the compound middle lamella. Both antibodies indicated labelling in pit membranes and ray cell walls in partially and fully lignified wood fibres.
Linear optical response of Si 1-x Ge x compounds (2005)

Si<sub>1-x</sub>Ge<sub>x</sub> is a good candidate as a substitute material for Si in a low-power and high-speed semiconductor device technologies. Optical devices, such as heterojunction bipolar transistors, are already in industrial production. The samples are grown on Si(001) with both <i>n</i>- and <i>p</i>-type impurities and with different Ge concentrations. The linear optical response of Si<sub>1-x</sub>Ge<sub>x</sub> is investigated theoretically using a full-potential linearized augmented plane wave method with respect to composition <i>x</i>. The calculated real and imaginary parts of the dielectric function &epsilon;(&omega;) = &epsilon;<sub>1</sub>(&omega;) + <i>i</i>&epsilon;<sub>2</sub>(&omega;) were found to be in good agreement with recent spectroscopic ellipsometry measurements performed by Bahng <i>et al</i>., J. Phys.: Condens. Matter <b>13</b>, 777 (2001). We also perform absorption measurements for different type of samples showing the variation of energy gaps as a function of Ge concentrations.
Immune response of peripheral blood mononuclear cells to HBx-antigen of hepatitis B virus (1991)

The hepatitis B virus genome encodes a transcriptional transactivator protein designated HBxAg. We have investigated whether this antigen is a target structure for human T-lymphocytes. Using recombinant HBxAg protein, we found HBxAg-specific stimulation of peripheral blood mononuclear cells in patients with acute hepatitis B virus infection (6 of 6) and chronic hepatitis B virus infection (6 of 17) but not in healthy individuals. With HBxAg-specific synthetic polypeptides, several T-cell epitopes were identified. Most were located in the carboxyterminal half of the HBxAg protein. Five T-cell clones specific for a T-cell epitope located at the carboxyterminal region of HBxAg were established and found to belong to the CD2/CD4-positive, CD8-negative subtype. These data establish for the first time HBxAg as an antigen in the cellular immune response.
Combination of Mycobacterium tuberculosis RS ratio and CFU improves the ability of murine efficacy experiments to distinguish between drug treatments (2021)

ABSTRACT Murine tuberculosis drug efficacy studies have historically monitored bacterial burden based on colony forming units of M. tuberculosis in lung homogenate. In an alternative approach, a recently described molecular pharmacodynamic marker called the RS ratio quantifies drug effect on a fundamental cellular process: ongoing ribosomal RNA synthesis. Here we evaluated the ability of different pharmacodynamic markers to distinguish between treatments in three BALB/c mouse experiments at two institutions. We confirmed that different pharmacodynamic markers measure distinct biological responses. We found that a combination of pharmacodynamic markers distinguishes between treatments better than any single marker. The combination of the RS ratio with colony forming units showed the greatest ability to recapitulate the rank order of regimen treatment-shortening activity, providing proof of concept that simultaneous assessment of pharmacodynamic markers measuring different properties will enhance insight gained from animal models and accelerate development of new combination regimens. These results suggest potential for a new era in which antimicrobial therapies are evaluated not only on culture-based measures of bacterial burden but also on molecular assays that indicate how drugs impact the physiological state of the pathogen.
Synthesis and characterization of iPP‐sPP stereoblock produced by a binary metallocene system (2014)

ABSTRACT Stereoblock polypropylenes comprising of i PP and s PP segments are synthesized by polymerization of the following binary system of metallocenes: the C s ‐symmetric [2,7‐t‐Bu 2 (Flu) 2 Ph 2 C(Cp)ZrCl 2 ] and the C 2 ‐symmetric rac ‐Me 2 Si(2‐Me‐4‐Ph‐Ind) 2 ZrCl 2 . Blends of samples made either by each catalyst individually (solution blend) with materials obtained with the mixed catalyst system (reactor blend) are compared. The simultaneous presence of MAO and DEZ, enhancing fast and reversible transfer of the growing chains between the two active centers, leads to the formation of a stereoblock microstructure. In this case, low molecular weight polymers are obtained. The junction between the blocks is qualitatively observed in 13 C NMR. When made in toluene, the stereoblock material consists of a majority of syndiotactic sequences, whereas the ratio is more equilibrated when the polymerization was conducted in the more polar chlorobenzene. This is confirmed by the results obtained with 13 C NMR, CRYSTAF, HT HPLC, DSC, SSA, WAXD, and optical microscopy. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014 , 52 , 1422–1434
Mechanical properties of mesoporous ceria nanoarchitectures (2014)

Architectural constructs are engineered to impart desirable mechanical properties facilitating bridges spanning a thousand meters and buildings nearly 1 km in height. However, do the same 'engineering-rules' translate to the nanoscale, where the architectural features are less than 0.0001 mm in size? Here, we calculate the mechanical properties of a porous ceramic functional material, ceria, as a function of its nanoarchitecture using molecular dynamics simulation and predict its yield strength to be almost two orders of magnitude higher than the parent bulk material. In particular, we generate models of nanoporous ceria with either a hexagonal or cubic array of one-dimensional pores and simulate their responses to mechanical load. We find that the mechanical properties are critically dependent upon the orientation between the crystal structure (symmetry, direction) and the pore structure (symmetry, direction).
Investigation of the Reorientation Effect inCd110andCd114 (1971)

In contrast to earlier measurements reporting a large negative quadrupole moment for the ${2}^{+}$ state in ${\mathrm{Cd}}^{114}$ near the rotational model value of -0.65e b, new detailed investigations of the reorientation effect in ${\mathrm{Cd}}^{114}$ yield ${Q}_{{2}^{+}}=(\ensuremath{-}0.28\ifmmode\pm\else\textpm\fi{}0.09)$e b with $B(E2;0\ensuremath{\rightarrow}2)=(0.513\ifmmode\pm\else\textpm\fi{}0.005)$${\mathit{e}}^{2}$ ${\mathrm{b}}^{2}$, or ${Q}_{{2}^{+}}=(\ensuremath{-}0.03\ifmmode\pm\else\textpm\fi{}0.09)$e b with $B(E2;0\ensuremath{\rightarrow}2)=(0.512\ifmmode\pm\else\textpm\fi{}0.005)$${\mathit{e}}^{2}$ ${\mathrm{b}}^{2}$. For ${\mathrm{Cd}}^{110}$, ${Q}_{{2}^{+}}=[\ensuremath{-}(0.42 or 0.21)\ifmmode\pm\else\textpm\fi{}0.10]$e b with $B(E2;0\ensuremath{\rightarrow}2)=(0.432\ifmmode\pm\else\textpm\fi{}0.006)$${\mathit{e}}^{2}$ ${\mathrm{b}}^{2}$.
Polyethylene Glycol (PEG) Linked to Near Infrared (NIR) Dyes Conjugated to Chimeric Anti-Carcinoembryonic Antigen (CEA) Antibody Enhances Imaging of Liver Metastases in a Nude-Mouse Model of Human Colon Cancer (2014)

We report here that polyethylene glycol (PEG) linked to near infrared dyes conjugated to chimeric mouse-human anti-carcinoembryonic antigen (CEA) antibody greatly improves imaging of liver metastases in a nude mouse model of colon-cancer experimental metastases. PEGylated and non-PEGylated DyLight 650 and 750 dyes were conjugated to the chimeric anti-CEA antibody. The dyes were initially injected intravenously into nude mice without tumors. Tissue biodistribution was determined by tissue sonication and analyzing tissue dye concentration profiles over time. PEGylated dyes had significantly lower accumulation in the liver (p = 0.03 for the 650 dyes; p = 0.002 for the 750 dyes) compared to non-PEGylated dyes. In an experimental liver metastasis model of HT-29 colon cancer, PEGylated dyes conjugated to the anti-CEA antibody showed good labeling of metastatic tumors with high contrast between normal and malignant tissue which was not possible with the non-PEGylated dyes since there was so much non-specific accumulation in the liver. PEGylation of the DyLight 650 and 750 NIR dyes significantly altered tissue biodistribution, allowing brighter tissue labeling, decreased accumulation in normal organs, particularly the liver. This enabled high fidelity and high contrast imaging of liver metastases.
The Outcome of Lumbar Discectomy in Elite Athletes (1999)

All patients were satisfied with their surgeries, were greatly improved, and were pain free in activities of daily living. For a single-level microdiscectomy, the success rate in elite athletes is excellent, with 90% of athletes able to return to a high level of competition. Two-level disease may be associated with a less favorable outcome.
A simple technique to improve performance of RAKE receivers in CDMA PCS indoor systems (2003)

In channels where the delay spread is smaller than the chip interval, spread spectrum signals do not give rise to path diversity, thus a classical maximal ratio combiner (MRC)-RAKE receiver sets to unity the number of branches. In this situation, MRC-RAKE receivers with resolution reduction (RR) of the diversity branches may be used to significantly improve performance in the forward link of DS-CDMA systems (Yang 1995). As a result of the use of RR techniques, the noise components at the finger outputs are correlated. It has been shown that the MRC is suboptimal in the presence of correlated noise components. In this paper, a minimum mean squared error combiner (MMSEC) RAKE receiver with RR is proposed. The performance of the RAKE receiver with two branches is studied by means of theoretical analysis and computer simulations. To allow a simple practical implementation, a suboptimal structure of the MMSEC is also proposed. Frame error rate (FER) is obtained by using a simulation system based on the forward link of the digital cellular standard IS-95 in a typical indoor radio channel. Our results show that this new receiver scheme can achieve a gain of 3.6 dB over a conventional MRC-RAKE receiver at an FER of 0.01, with small increase in complexity.
Radial nerve myofibroma: a rare benign tumor with perineural infiltration. Illustrative case (2023)

Perineural pseudoinvasion can be an extremely rare and atypical feature of nonmalignancies, resulting in dense motor weakness. Extensive nerve involvement may still necessitate nerve resection and reconstruction, despite the benign etiology of the lesion.