gebhart/patrepeval huggingface dataset:
Specificity of synergistic coronary flow enhancement by adenosine and pulsatile perfusion in the dog (1999)

1. Coronary flow elevation from enhanced perfusion pulsatility is synergistically amplified by adenosine. This study determined the specificity of this interaction and its potential mechanisms. 2. Mean and phasic coronary flow responses to increasing pulsatile perfusion were assessed in anaesthetized dogs, with the anterior descending coronary artery servoperfused to regulate real-time physiological flow pulsatility at constant mean pressure. Pulsatility was varied between 40 and 100 mmHg. Hearts ejected into the native aorta whilst maintaining stable loading. 3. Increasing pulsatility elevated mean coronary flow +11.5 +/- 1.7 % under basal conditions. Co-infusion of adenosine sufficient to raise baseline flow 66 % markedly amplified this pulsatile perfusion response (+82. 6 +/- 14.3 % increase in mean flow above adenosine baseline), due to a leftward shift of the adenosine-coronary flow response curve at higher pulsatility. Flow augmentation with pulsatility was not linked to higher regional oxygen consumption, supporting direct rather than metabolically driven mechanisms. 4. Neither bradykinin, acetylcholine nor verapamil reproduced the synergistic amplification of mean flow by adenosine and higher pulsatility, despite being administered at doses matching basal flow change with adenosine. 5. ATP-sensitive potassium (KATP) activation (pinacidil) amplified the pulse-flow response 3-fold, although this remained significantly less than with adenosine. Co-administration of the phospholipase A2 inhibitor quinacrine virtually eliminated adenosine-induced vasodilatation, yet synergistic interaction between adenosine and pulse perfusion persisted, albeit at a reduced level. 6. Thus, adenosine and perfusion pulsatility specifically interact to enhance coronary flow. This synergy is partially explained by KATP agonist action and additional non-flow-dependent mechanisms, and may be important for modulating flow reserve during exercise or other high output states where increased flow demand and higher perfusion pulsatility typically co-exist.
Dendritic Mesoporous Organosilica Nanoparticles with Photosensitizers for Cell Imaging, siRNA Delivery and Protein Loading (2023)

Dendritic Mesoporous Organosilica Nanoparticles (DMON) are a new class of biodegradable nanoparticles suitable for biomolecules delivery. In order to escape from the endosomes-lysosomes and to deliver biomolecules in the cytoplasm of cells, we studied photochemical internalization (PCI) and photodynamic therapy (PDT) of DMON. We added photosensitizers in the framework of DMON. DMON were also loaded with siRNA or FVIII factor protein. We made four formulations with four different photosensitizers, The photosensitizers allowed to perform imaging of DMON in cancer cells, but the presence of the tetrasulfide bond in the framework of DMON quenched the formation of singlet oxygen. Fortunately one formulation allowed to efficiently deliver proapoptotic siRNA in MCF-7 cancer cells leading to 31% of cancer cell death, without irradiation. For FVIII protein, it was loaded in two formulations with drug loading capacities (DLC) up to 25%. In conclusion DMON are versatile nanoparticles which allowed to load siRNA and to deliver it in cancer cells, and to load FVIII protein with good DLC. Due to the presence of tetrasulfide, it was not possible to perform PDT and PCI.
Reaching grid parity using bp solar crystalline silicon technology (2009)

This paper reports on BP Solar's DOE sponsored Technology Pathways Partnership. The paper presents the goals, the technical approach and progress for the first half of the three year program. The overall goals of the program are to reach grid parity for residential and commercial markets and to increase production volumes. This program is addressing all aspects of the PV product chain including: Solar grade silicon (SGS) development; Implementation of Mono <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2TM</sup> technology (single crystal quality at multi cost); Wafering thinner wafers using thinner wire; Optimized cell process for thin Mono <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2TM</sup> to achieve a cell efficiency of 18% in 2010; Lower module material costs and products designed for integration into specific roof types; Automation and process control for handling hundreds of cells per minute; and Inverters designed with the capability to dispatch batteries. During the first half of the program major accomplishments include: Pilot demonstration of the Mono <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2TM</sup> process; Achievement of 15.3% average cell efficiency using material cast using 50% SGS; Demonstration of the ability to cut 180 ¿m thick wafers using 120 ¿m diameter wire; Qualification and implementation of AR coated glass from a US vendor; Demonstration of a rapid method of measuring EVA cure level; Design of a building integrated PV roofing tile; and Successful demonstration of the ability to remotely dispatch and recharge a battery.
Dopamine agonists: effects of charged and uncharged analogs of dopamine (1987)

Dopamine, at physiological pH, may exist as either an uncharged amine or a charged ammonium species. In order to gain insight as to which species is better suited for interaction with the dopamine receptor, we have synthesized dopamine analogues in which the nitrogen atom is replaced with a neutral methyl sulfide, a neutral methyl selenide, a charged dimethylsulfonium iodide, and a charged dimethylselenonium iodide. These analogues were tested for their ability to inhibit the K+-stimulated release of [3H]acetylcholine from striatal slices. At 30 microM concentration, the charged sulfonium and selenonium salts possessed significant agonist activity while the corresponding neutral species were inactive, suggesting that a charged species is optimal for dopamine agonist activity. In addition, the methyl sulfide was converted into the corresponding sulfoxide and sulfone; however, neither of these oxidation products possessed significant activity as dopaminergic agonists.
The Design of Modulation Doped Heterostructures (1986)

This memo presents a set of design rules for the thickness and doping levels of the various layers of a modulation doped heterojunction. It is shown how to optimise the heterostructure so that there is no parasitic parallel conduction and for the maximum low temperature mobility. (Author)
Control of minimally persistent leader-remote-follower formations in the plane (2009)

This paper addresses the n-vehicle formation shape maintenance problem in the plane. The objective is to design decentralized motion control laws for each vehicle to restore formation shape in the presence of small perturbations from the desired shape. Formation shape is restored by actively controlling a certain set of interagent distances, and we assign the task of controlling a particular interagent distance to only one of the involved agents. We restrict our attention to a class of directed information architectures called minimally persistent leader-remote-follower. The nonlinear closed-loop system has a manifold of equilibria, which implies that the linearized system is nonhyperbolic. We apply center manifold theory to show local exponential stability of the desired formation shape. Choosing stabilizing gains is possible if a certain submatrix of the rigidity matrix has all leading principal minors nonzero, and we show that this condition holds for all leader-remote-follower formations with generic agent positions. Simulations are provided.
Real-time object detection, tracking and occlusion reasoning (2023)

A system for object detection and tracking includes technologies to, among other things, detect and track moving objects, such as pedestrians and/or vehicles, in a real-world environment, handle static and dynamic occlusions, and continue tracking moving objects across the fields of view of multiple different cameras.
Increased Expression of Apoptosis Inhibitor Protein XIAP Contributes to Anoikis Resistance of Circulating Human Prostate Cancer Metastasis Precursor Cells (2005)

Survival in lymph or blood is an essential prerequisite for metastasis of carcinoma cells to distant organs. Recently, we reported isolation and initial biological characterization of circulating metastatic cells in a fluorescent, orthotopic, metastatic nude-mouse model of human prostate cancer. Here we show that the metastatic human prostate carcinoma cells selected for survival in the circulation have increased resistance to anoikis, which is apoptosis induced by cell detachment. Using gene silencing and gene transfer techniques, we show that increased expression of the apoptosis inhibitory protein XIAP contributes to anoikis resistance of the circulating metastatic human prostate carcinoma cells. We also provide initial preclinical data on the antimetastatic efficacy of recently discovered small-molecule antagonists of XIAP.
GaN Quantum Dot UV-LED-Fabrication and Optical Characteristics (2004)

The fabrication and evaluation of an UV light-emitting diode (LED) with GaN quantum dots as the active layer is demonstrated. GaN quantum dots were fabricated on an AlxGa1-xN (x ~ 0.1) surface using Si antisurfactant. The Si antisurfactant exposed to the AlxGa1-xN surface prior to GaN enables quantum dot formation on a surface where growth in the Stranski-Krastanov mode is impossible. Fairly high density of dots (1010-1011 cm-2) with controllable dot sizes can be achieved. By current injection (cw) to the LED structure including GaN quantum dots clear room temperature luminescence at 360 nm was observed. The origin of the electroluminescence is discussed by comparing it to photoluminescence measurements.
A methodology for designing proof rules for fair parallel programs (1997)

Abstract We propose a methodology for designing sound and complete proof systems for proving progress properties of parallel programs under various fairness assumptions. Our methodology begins with a branching time temporal logic formula (CTL * ) formula that expresses progress under a fairness assumption. The next step obtains an equivalent fixpoint characterization of this CTL * formula in the μ -calculus. The final step uses the fixpoint characterizations to extract proof systems for proving progress under the fairness constraint. The methodology guarantees that the proof rules so obtained are sound and relatively complete in the sense of Cook.
Picomolar Analysis of Proteins Using Electrophoretically Mediated Microanalysis and Capillary Electrophoresis with Laser-Induced Fluorescence Detection (1998)

We report a method for the analysis of picomolar concentration proteins using electrophoretically mediated microanalysis (EMMA) to label proteins on-column with a fluorogenic reagent. Labeling is followed by capillary zone electrophoresis separation and postcolumn detection based on laser-induced fluorescence. The method provides a concentration detection limit (3 sigma) of 3 x 10(-13) M for conalbumin. The method provides separation efficiency of 300,000 theoretical plates. Protein extract from a human colon adenocarcinoma cell line generated a dozen major components and many minor components in a 12-min separation; the protein extract from 2.5 cells was used for this analysis. When compared to UV absorbance detection, the EMMA method provides 7,000,000-fold improvement in detection limit.
Kinetic Model Development for Lignin Pyrolysis (2012)

Lignin pyrolysis poses a significant barrier to the formation of liquid fuel products from biomass. Lignin pyrolyzes at higher temperatures than other biomass components (e.g. cellulose and hemi-cellulose) and tends to form radicals species that lead to cross-linking and ultimately char formation. A first step in the advancement of biomass-to-fuel technology is to discover the underlying mechanisms that lead to the breakdown of lignin at lower temperatures into more stable and usable products. We have investigated the thermochemistry of the various inter-linkage units found in lignin (B-O4, a-O4, B-B, B-O5, etc) using electronic structure calculations at the M06-2x/6-311++G(d,p) on a series of dimer model compounds. In addition to bond homolysis reactions, a variety of concerted elimination pathways are under investigation that tend to produce closed-shell stable products. Such a bottom-up approach could aid in the targeted development of catalysts that produce more desirable products under less severe reactor conditions.
N2A: a computational tool for modeling from neurons to algorithms (2014)

The exponential increase in available neural data has combined with the exponential growth in computing ("Moore's law") to create new opportunities to understand neural systems at large scale and high detail. The ability to produce large and sophisticated simulations has introduced unique challenges to neuroscientists. Computational models in neuroscience are increasingly broad efforts, often involving the collaboration of experts in different domains. Furthermore, the size and detail of models have grown to levels for which understanding the implications of variability and assumptions is no longer trivial. Here, we introduce the model design platform N2A which aims to facilitate the design and validation of biologically realistic models. N2A uses a hierarchical representation of neural information to enable the integration of models from different users. N2A streamlines computational validation of a model by natively implementing standard tools in sensitivity analysis and uncertainty quantification. The part-relationship representation allows both network-level analysis and dynamical simulations. We will demonstrate how N2A can be used in a range of examples, including a simple Hodgkin-Huxley cable model, basic parameter sensitivity of an 80/20 network, and the expression of the structural plasticity of a growing dendrite and stem cell proliferation and differentiation.
Effect of initial resist thickness on residual layer thickness of nanoimprinted structures (2005)

Quantification and control of the residual layer thickness is a critical challenge facing nanoimprint lithography. This thickness must be known to within a few nanometers, yet there are very few nondestructive measurement techniques capable of extracting such information. Here we describe a specular x-ray reflectivity technique that can be used to not only quantify the thickness of the residual layer with sub-nm resolution, but also to extract the pattern height, the line-to-space ratio, and relative linewidth variations as a function of the pattern height. This is illustrated through a series of imprints where the initial film thickness is varied. For films with sufficient resist material to fill the mold, complete pattern filling is observed and the residual layer thickness is directly proportional to the initial film thickness. When there is insufficient resist material in the film to completely fill the patterns in the mold, a finite residual layer thickness of approximately 50–100Å is still observed.
Chemistry and Biology of Ramoplanin:  A Lipoglycodepsipeptide with Potent Antibiotic Activity (2005)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry and Biology of Ramoplanin: A Lipoglycodepsipeptide with Potent Antibiotic ActivitySuzanne Walker, Lan Chen, Yanan Hu, Yosup Rew, Dongwoo Shin, and Dale L. BogerView Author Information The Department of Microbiology & Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, The Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, and The Department of Chemistry, Princeton University, Princeton, New Jersey 08544 Cite this: Chem. Rev. 2005, 105, 2, 449–476Publication Date (Web):January 15, 2005Publication History Received12 July 2004Published online15 January 2005Published inissue 1 February 2005https://pubs.acs.org/doi/10.1021/cr030106nhttps://doi.org/10.1021/cr030106nresearch-articleACS PublicationsCopyright © 2005 American Chemical SocietyRequest reuse permissionsArticle Views2134Altmetric-Citations125LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Antimicrobial agents,Assays,Inhibition,Lipids,Peptides and proteins Get e-Alerts
Novel aminoalkyl tris-cyclometalated iridium complexes as cellular stains (2016)

Herein we report the synthesis and investigation of the properties of two tris-cyclometalated luminescent iridium complexes. These complexes are the simple derivatives of fac-[Ir(ppy)<sub>3</sub>] bearing amino alkyl groups on one of the phenylpyridine rings. The complexes are highly emissive and exhibit structured emission peaks in aqueous solution while having only broad unstructured emission in organic solvents. The complexes have been shown to be taken up by NIH-3T3 and PC3 cells, where they localize in the lysosomes and remain emissive with lifetimes in the microsecond domain.
5G public network integration for a real-life PROFINET application (2022)

The 3rd Generation Partnership Project (3GPP) has introduced technical features for Non-Public Networks (NPN), allowing highly flexible and dedicated 5G deployments for Industry 4.0 applications. This paper presents insights into the early adoption of a 5G Public Network Integration Non-Public Network (PNI-NPN) for industrial automation applications with observed network performance. Our contributions are threefold: (i) we present network design concepts to overcome the challenges of industrial use-cases and mobile network limitations, (ii) we propose network architecture over 5G Non-Standalone architecture (NSA), and (iii) we perform validation measurements with PROFINET and PROFIsafe communication. Our results – at a real industrial 5G setting – indicate that the proposed architecture is very promising for future 5G industrial deployments.
Real-time gastric motility monitoring using transcutaneous intraluminal impedance measurements (TIIM) (2014)

The stomach plays a critical role in digestion, processing ingested food mechanically and breaking it up into particles, which can be effectively and efficiently processed by the intestines. When the motility of the stomach is compromised, digestion is adversely affected. This can lead to a variety of disorders. Current diagnostic techniques for gastric motility disorders are seriously lacking, and are based more on eliminating other possibilities rather than on specific tests. Presently, gastric motility can be assessed by monitoring gastric emptying, food transit, intragastric pressures, etc. The associated tests are usually stationary and of relatively short duration. The present study proposes a new method of measuring gastric motility, utilizing the attenuation of an oscillator-induced electrical signal across the gastric tissue, which is modulated by gastric contractions. The induced high-frequency oscillator signal is generated within the stomach, and is picked up transluminally by cutaneous electrodes positioned on the abdominal area connected to a custom-designed data acquisition instrument. The proposed method was implemented in two different designs: first a transoral catheter was modified to emit the signal inside the stomach; and second, a gastric retentive pill was designed to emit the signal. Both implementations were applied in vivo on two mongrel dogs (25.50 kg and 25.75 kg). Gastric contractions were registered and quantitatively compared to recordings from force transducers sutured onto the serosa of the stomach. Gastric motility indices were calculated for each minute, with transluminal impedance measurements and the measurements from the force transducers showing statistically significant (p < 0.05) Pearson correlation coefficients (0.65 ± 0.08 for the catheter-based design and 0.77 ± 0.03 for the gastric retentive pill design). These results show that transcutaneous intraluminal impedance measurement has the potential with further research and development to become a useful diagnostic technique.
Test and Evaluation of TRUST: Tools for Recognizing Useful Signals of Trustworthiness (2016)

Abstract : This study focuses on the measurement of trustworthiness. The report focuses on testing, research and evaluation of a new research method for measuring and requiring trust between individuals. Not only did this study attempt to understand the holistic neural, psychophysiological, psychological, and behavioral underpinnings of the nature of trust, but more broadly, enhance understanding of the social dynamic of human interaction vital to the success of everyday life, especially in the defense and intelligence community context. The study was adapted from a well-evaluated game theory paradigm (Prisoners Dilemma). The Prisoners Dilemma puts study participants in a situation where they must decide to trust or not trust an assigned partner. Their decisions and the decisions of their partners, to trust or not trust are determined by the amount of monetary compensation participants were given at the end of the experimental session. The study goal was to evaluate the extent to which particular behavioral, psychological, physiological, and neural signals are related to trust between two people. Many areas were studied for this report, including frontal alpha power asymmetry, electroencephalography (EEG), high- and low-frequency and RR interval of heart rate, electrocardiography (ECG), skin conductance levels and Galvanic Skin Response (GSR), oxytocin and cortisol concentrations, and psychological state (questionnaires). These areas were investigated using three different methodological transformations: one examining raw signals, and two adjusting the signals to baseline: minus baseline and divided by baseline. Applied throughout the report are six hypotheses derived from Social Exchange Model. The six hypotheses are provided in the report.
Performance Comparison of Mesoscale Refrigeration Technologies for Electronics Packaging (2003)

Utilizing refrigeration is one alternative to improve the operating performance of microelectronic devices. Unless large-scale refrigeration systems are acceptable, it is likely that miniature, or mesoscale, refrigerators will be required that can be directly incorporated into electronic packaging. The present study builds on the authors’ previous investigation of mesoscale refrigerators, which emphasized how only thermoelectric coolers (TEC’s) are capable of being miniaturized in the near future. Many other refrigeration systems, however, are being examined for their potential to be miniaturized, including the vapor-compression, Stirling, and pulse-tube cycles. Here a simple analysis is presented that shows the feasibility of utilizing these systems in electronics packaging. One finding is that, provided a suitable mesoscale compressor can be constructed, a vapor-compression refrigerator may yield the best performance of the investigated systems.
Flame retardant Polyamide : different approaches to reach high performances (2018)

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