gebhart/patrepeval huggingface dataset:
Mesoporous thin films as versatile sensitive matrices on Love wave sensors for fast sub-ppm vapor detection (2009)

Love wave gas sensors with mesoporous thin film as sensitive layers are presented. They are dedicated to volatile organic compound vapor detection. Mesoporous films of SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> were prepared using the sol-gel process and deposited on the devices acoustic path. The obtained films have been characterized by ellipsometry resulting in the determination of porosity and pore size distribution in the film and of water adsorption isotherms. Ethanol (130-2000 ppm) and toluene (70-1000 ppm) exposures resulted in frequency shifts up to 20 kHz, showing the high sensitivity of the mesoporous-based Love wave devices.
Opening the ‘black box’: oscillations in organocuprate conjugate addition reactions (2005)

Under the conditions of a rapid injection experiment, the conjugate addition reactions of butyl Gilman reagents with 2-cyclohexenone undergo oscillations of a complex nature.
Abstract 2721: Linkage of Left Ventricular Outflow Tract Obstruction to Xq28 in 3 French-Canadian Pedigrees (2007)

BACKGROUND: Statistical genetic analysis of cohorts with left ventricular outflow tract obstruction (LVOTO) shows high heritability of such lesions. We have identified three X-linked French-Canadian pedigrees with a total of 54 family members with multiple cases of LVOTO and septal defects. AIMS: The aim of this study was to evaluate the three pedigrees with LVOTO and septal defects for genetic linkage to the X chromosome. METHODS: Detailed family history, physical exam, ECG, echocardiography and chart review was performed. Informed consent was obtained from all participants. Genomic DNA was isolated from peripheral blood samples. Twenty-four STR markers from the X chromosome were genotyped. We used a dominant genetic model with the following penetrances: 0.99 for homozygous women, 0.75 for heterozygous women, 0.99 for hemizygous men. Phenocopy rate was set to 0.01 and disease allele frequency to 0.001. Reference allele frequencies from the Quebec population were used. Analyses were performed with MLINK and MERLIN. RESULTS: Sixteen family members were affected (13 males, 3 females). Predominant lesions were atrial (n = 5) and ventricular (n = 6) septal defects, coarctation (n = 4) and aortic lesions (stenosis (n = 4), bicuspid/abnormal aortic valve (n = 6)), as well as mitral valve lesions (n = 4). Males had a high incidence of supraventricular arrhythmias postoperatively (4 with atrial flutter/fibrillation, one with ICD implantation). LOD scores above 2 were obtained in parametric two-point linkage analysis for 3 markers in the Xq28 region. Multipoint non-parametric linkage analysis confirmed these results with a NPL score of 9.1 (P &lt; .00001) over a STR marker in intron 13 of the F8C gene. Haplotype analysis allowed the definition of a candidate interval flanked by marker DXS8069 spanning to the telomeric end of Xq. CONCLUSIONS: By analysing 3 multi-generation French-Canadian pedigrees, we mapped a syndrome of LVOTO and septal defects to the Xq28 region. Further work will refine our candidate region with dense SNP coverage to search for a shared haplotype identical by descent between the three French Canadian families, to complete the sequencing of candidate genes including FLNA, and to search for a possible founder effect in our population.
Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo (2021)

Antimicrobial resistance is an increasing threat to global health and challenges the way we treat infections. Peptides containing the PCNA interacting motif APIM (APIM-peptides) were recently shown to bind to the bacterial PCNA homolog, the beta (β)-clamp, and to have both antibacterial and anti-mutagenic activities. In this study we explore the antibacterial effects of these peptides on <i>Staphylococcus epidermidis</i>, a bacterial species commonly found in prosthetic joint infections (PJI). Drug-resistant bacterial isolates from PJIs often lead to difficult-to-treat chronic infections. We show that APIM-peptides have a rapid bactericidal effect which when used at sublethal levels also increase the efficacy of gentamicin. In addition, APIM-peptides reduce development and eliminate already existing <i>S. epidermidis</i> biofilm. To study the potential use of APIM-peptides to prevent PJI, we used an <i>in vivo</i> bone graft model in rats where APIM-peptide, gentamicin, or a combination of the two was added to cement. The bone grafts containing cement with the combination was more effective than cement containing only gentamicin, which is the current standard of care. In summary, these results suggest that APIM-peptides can be a promising new drug candidate for anti-infective implant materials to use in the fight against resistant bacteria and chronic PJI.
ChemInform Abstract: Cobalt‐Catalyzed Hydrosilation/Hydrogen‐Transfer Cascade Reaction: A New Route to Silyl Enol Ethers. (2013)

Abstract A novel cobalt‐catalyzed method for the synthesis of silyl enol ethers from ketones is described.
MP99-14 PDCD4 IS A CHECK POINT OF MIR-21 INDUCED CASTRATION RESISTANCE IN HUMAN PROSTATE CANCER (2017)

On multivariate analysis, preoperative PSA level and high nYAP intensity score were independent prognostic factors for BCR in patients with PCa treated with CHT.CONCLUSIONS: nYAP expression in residual cancer cells is a potential prognostic marker for BCR in high-risk PCa patients who underwent RP after neoadjuvant chemohormonal therapy.The Hippo pathway may play an important role in chemohormonal resistance in patients with PCa.
Inactivation of an enterovirus by airborne disinfectants (2013)

This study demonstrates that the virucidal activity of airborne disinfectants can be tested on dried poliovirus.
PRICKLE1 Interaction with SYNAPSIN I Reveals a Role in Autism Spectrum Disorders (2013)

The frequent comorbidity of Autism Spectrum Disorders (ASDs) with epilepsy suggests a shared underlying genetic susceptibility; several genes, when mutated, can contribute to both disorders. Recently, PRICKLE1 missense mutations were found to segregate with ASD. However, the mechanism by which mutations in this gene might contribute to ASD is unknown. To elucidate the role of PRICKLE1 in ASDs, we carried out studies in Prickle1 +/2 mice and Drosophila, yeast, and neuronal cell lines. We show that mice with Prickle1 mutations exhibit ASD-like behaviors. To find proteins that interact with PRICKLE1 in the central nervous system, we performed a yeast two-hybrid screen with a human brain cDNA library and isolated a peptide with homology to SYNAPSIN I (SYN1), a protein involved in synaptogenesis, synaptic vesicle formation, and regulation of neurotransmitter release. Endogenous Prickle1 and Syn1 co-localize in neurons and physically interact via the SYN1 region mutated in ASD and epilepsy. Finally, a mutation in PRICKLE1 disrupts its ability to increase the size of dense-core vesicles in PC12 cells. Taken together, these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles.
Green Emitting Single-Crystalline Bulk Assembly of Metal Halide Clusters with Near-Unity Photoluminescence Quantum Efficiency (2019)

Organic metal halide hybrids with zero-dimensional (0D) structure at the molecular level, or single-crystalline bulk assemblies of metal halides, are an emerging class of light-emitting materials with high photoluminescence quantum efficiencies (PLQEs) and color tunability. Here we report the synthesis and characterization of a new single-crystalline bulk assembly of metal halide clusters, (bmpy)9[ZnCl4]2[Pb3Cl11] (bmpy: 1-butyl-1-methylpyrrolidinium), which exhibits green emission peaked at 512 nm with a remarkable near-unity PLQE at room temperature. Detailed structural and photophysical studies suggest that there are two emitting states in [Pb3Cl11]5– clusters, whose populations are strongly dependent on the surrounding molecular environment that controls the excited-state structural distortion of [Pb3Cl11]5– clusters. High chemical- and photostability have also been demonstrated in this new material.
Measurement of the production cross section for a Higgs boson in association with a vector boson in the H → WW⁎ → ℓνℓν channel in pp collisions at s=13 TeV with the ATLAS detector (2019)

A measurement of the Higgs boson production cross sections via associated W H and Z H production using H W W * decays, where stands for either an electron or a muon, is presented. Results for combined W H and Z H production are also presented. The analysis uses events produced in protonproton collisions collected with the ATLAS detector at the Large Hadron Collider in 2015 and 2016. The data correspond to an integrated luminosity of 36.1 fb -1 recorded at a centre-of-mass energy of 13 TeV.
Development of a Humanized HLA-A2.1/DP4 Transgenic Mouse Model and the Use of This Model to Map HLA-DP4-Restricted Epitopes of HBV Envelope Protein (2012)

A new homozygous humanized transgenic mouse strain, HLA-A2.1(+/+)HLA-DP4(+/+) hCD4(+/+)mCD4(-/-)IAβ(-/-)β2m(-/-) (HLA-A2/DP4), was obtained by crossing the previously characterized HLA-A2(+/+)β2m(-/-) (A2) mouse and our previously created HLA-DP4(+/+) hCD4(+/+)mCD4(-/-)IAβ(-/-) (DP4) mouse. We confirmed that the transgenes (HLA-A2, HLA-DP4, hCD4) inherited from the parental A2 and DP4 mice are functional in the HLA-A2/DP4 mice. After immunizing HLA-A2/DP4 mice with a hepatitis B DNA vaccine, hepatitis B virus-specific antibodies, HLA-A2-restricted and HLA-DP4-restricted responses were observed to be similar to those in naturally infected humans. Therefore, the present study demonstrated that HLA-A2/DP4 transgenic mice can faithfully mimic human cellular responses. Furthermore, we reported four new HLA-DP4-restricted epitopes derived from HBsAg that were identified in both vaccinated HLA-A2/DP4 mice and HLA-DP4-positive human individuals. The HLA-A2/DP4 mouse model is a promising preclinical animal model carrying alleles present to more than a quarter of the human population. This model should facilitate the identification of novel HLA-A2- and HLA-DP4-restricted epitopes and vaccine development as well as the characterization of HLA-DP4-restricted responses against infection in humans.
A microfluidic device for label-free isolation of tumor cell clusters from unprocessed blood samples (2019)

Primary cancers disseminate both single circulating tumor cells (CTCs) and CTC "clusters," the latter of which have been shown to demonstrate greater metastatic propensity and adverse impact on prognosis. Many devices developed to isolate single CTCs also capture CTC clusters, but there is translational potential for a platform specifically designed to isolate CTC clusters. Herein, we introduce our microfluidic device for isolating CTC clusters ("Microfluidic Isolation of CTC Clusters" or MICC), which is equipped with ∼10 000 trap chambers that isolate tumor cell clusters based on their large sizes and dynamic force balance against a pillar obstacle in the trap chamber. Whole blood is injected, followed by a wash step to remove blood cells and a final backflush to release intact clusters for downstream analysis. Using clusters from tumor cell-line and confocal microscopy, we verified the ability of the MICC platform to specifically capture tumor cell clusters in the trap chambers. Our flow rate optimization experiments identified 25 <i>μ</i>l/min for blood injection, 100 <i>μ</i>l/min as wash flow rate, and 300 <i>μ</i>l/min as the release flow rate - indicating that 1 ml of whole blood can be processed in less than an hour. Under these optimal flow conditions, we assessed the MICC platform's capture and release performance using blood samples spiked with different concentrations of clusters, revealing a capture efficiency of 66%-87% and release efficiency of 76%-90%. The results from our study suggest that the MICC platform has the potential to isolate CTC clusters from cancer patient blood, enabling it for clinical applications in cancer management.
Development of CO 2 laser produced Xe plasma EUV light source for microlithography (2006)

A CO<sub>2</sub> laser driven Xe droplet plasma is presented as a light source for EUV lithography. A short-pulse TEA CO<sub>2</sub> master oscillator power amplifier system and a pre-pulse Nd:YAG laser were used for initial experiment with 0.6% of CE from a Xe jet. A target technology is developed for high average power experiments based on a Xe droplet at 100kHz. Magnetic field ion mitigation is shown to work well in the pre-pulsed plasma combined with a CO<sub>2</sub> laser main pulse. This result is very promising with respect to collector mirror lifetime extension by magnetic field mitigation. A master oscillator power amplifier (MOPA) CO<sub>2</sub> laser system is under development with a few kW and 100 kHz repetition rate with less than 15ns laser pulse width using a waveguide Q-switched CO<sub>2</sub> laser oscillator and RF-excited fast axial flow CO<sub>2</sub> laser amplifiers.
Electromagnetic fast firing for ultrashallow junction formation (2003)

The creation of low resistivity, ultrashallow source/drain regions in MOS device structures requires rapid thermal processing (RTP) techniques that restrict diffusion and activate a significant percentage of the implanted dopant species. While current heating techniques depend upon illumination based heating, a new technology, electromagnetic induction heating (EMIH), achieves a rapid heating of the silicon by coupling electromagnetic radiation directly into the silicon wafer. Heating rates of 125/spl deg/C/s to temperatures in excess of 1050/spl deg/C have been achieved for 75- and 100-mm-diameter wafers at input powers of 1000 and 1300 W, respectively. These ramp rates are suitable for ultrashallow junction formation, and junctions shallower than 30 nm with sheet resistances lower than 600 /spl Omega//square have been achieved. This paper details the application of electromagnetic heating using radiation in the microwave, 2450 MHz, frequency regime. Experimental results, comparing microwave annealed implants to the well documented SEMATECH requirements, and simulations, utilizing a coupled electromagnetic-thermal computer model, of the heating process are discussed.
Prevalence and causes of vision loss in South-east Asia and Oceania in 2015: magnitude, temporal trends and projections (2018)

In both regions, the main challenges for eye care come from cataract which remains the main cause of blindness with uncorrected refractive error the main cause of MSVI. The trend between 1990 and 2015 is for a lower prevalence of blindness and MSVI in both regions.
Error dependencies on classes of implementations under testing (2012)

The paper discusses the problem of dependency between errors defined by specification and the related problem of test optimization. There is a dependency between errors if a strict subset of errors exists such that any nonconforming implementation (i.e. an implementation containing an error) contains an error from this subset. Accordingly, it is sufficient for the tests to detect errors only from this subset. The most general formal model of test interaction and the reduction type of conformance are suggested, for which dependency between errors is almost absent. Most of the known conformances in various interaction semantics are demonstrated to be special cases of this general model. In this general model, the dependency between errors may occur when any strict subset of the class of all implementations is chosen as a class of implementations under testing. Particular interaction semantics and/or various hypotheses on implementations (specifically, the safety hypothesis), in fact, assume that the implementation under testing should belong to some subclass of (safe) implementations.
Physico‐chemical characterization and synthesis of neuronally active α‐conotoxins (2004)

The high specificity of alpha-conotoxins for different neuronal nicotinic acetylcholine receptors makes them important probes for dissecting receptor subtype selectivity. New sequences continue to expand the diversity and utility of the pool of available alpha-conotoxins. Their identification and characterization depend on a suite of techniques with increasing emphasis on mass spectrometry and microscale chromatography, which have benefited from recent advances in resolution and capability. Rigorous physico-chemical analysis together with synthetic peptide chemistry is a prerequisite for detailed conformational analysis and to provide sufficient quantities of alpha-conotoxins for activity assessment and structure-activity relationship studies.
Advances in iridium alloy processing in FY 1988 (1988)

A new process for the production of DOP-26 iridium alloy blanks is being evaluated and optimized. The alloy is prepared by electron-beam (EB) melting of Ir-0.3% W powder compacts followed by doping with aluminum and thorium by arc melting. Drop-cast alloy rod segments are EB welded together into an electrode that is arc melted to produce an ingot for extrusion and subsequent sheet rolling and blanking. Initial results showed rejections for ultrasonic indications for alloy blanks fabricated by this process to be very low. Subsequently, some ingots have exhibited delaminations in the sheet, leading to blank rejection rates similar to that obtained in the standard process. The occurrence of ultrasonic indications in the blanks are now shown to be associated with the presence of subsurface flaws in the arc-melted ingot that are not healed during extrusion or the subsequent rolling of the sheet. There is substantial evidence indicating that the occurrence of surface and subsurface flaws in the ingots are exacerbated by the relatively small clearances between the electrode and the side wall of the 51-mm-diam mold. These results obtained from experimental melts, with both stainless steel and scrap iridium alloy materials, have led to a recommendation for arc meltingmore » in a large 63-mm-diam mold. The fabrication of blanks from this larger diameter ingot is under way. The efficiency of iridium material utilization in the new process is also discussed. 2 refs., 23 figs., 12 tabs.« less
Synthesis of [1]benzothieno[3,2‐d]pyrimidines substituted with electron donating substituents on the benzene ring (1997)

Abstract Various 2‐fluorobenzonitriles were converted to the corresponding 3‐amino[1]benzothiophenecarboxylic acid esters, which in turn were annulated with formamidine or various equivalents to produce the desired tricyclic benzothienopyrimidines. Various methoxy and nitro/amino substituents were placed on the phenyl ring, requiring several different strategies to prepare the desired benzothiophenes. Several different pyrimidone annulations were also required. The use of an electron rich 2‐bromobenzonitrile in a four‐step one‐pot low temperature lithiation sequence to produce highly electron‐rich amino[1]benzothiophenecarboxylate esters is also described. The synthesis of 7‐amino‐8‐fluoro[1]benzothieno[3,2‐ d ]pyriinid‐4(3 H )‐one was relatively straightforward, but synthesis of the corresponding 7‐amino‐8‐protio analogue proved to be very difficult, and required several approaches before a successful one was found.
Electronic structure and effective masses of InN under pressure (2008)

The pressure dependence of the electronic band structure of InN is investigated with emphasis on the conduction band effective mass and its dependence on free-electron concentration. Transport measurements are performed under hydrostatic pressure on three n-type samples of InN with different electron concentrations. The effective mass extracted from the electron mobility is found to increase with pressure, however with a pressure coefficient, which is lower for the samples with higher electron concentration. Calculations of the InN band structure are performed within the density functional theory by means of the linear muffin-tin-orbital method, including an empirical adjustment to reproduce known band edges at ambient pressure. The calculated variations of the highest occupied conduction band energy and the electron effective mass with free-electron concentration are compared to available experimental information. The results show a pronounced deviation from parabolic behavior of the lowest conduction band, and for k&amp;gt;0 this induces large differences between the values of the optical and curvature masses. Both the fundamental band gap and the electron effective mass increase with pressure, but due to the nonparabolic character of the conduction band, the pressure coefficient of the effective mass decreases with electron concentration, in agreement with the experimental observation.
Supplementary Table 2 from Paxillin Is a Target for Somatic Mutations in Lung Cancer: Implications for Cell Growth and Invasion (2023)

Supplementary Table 2 from Paxillin Is a Target for Somatic Mutations in Lung Cancer: Implications for Cell Growth and Invasion
Thermal Decomposition of Wood-Derived Organic Matter under Specific Industrial Process Conditions (2019)

Pyrolysis of wood and other ligneous biomass is a complex degradation process that produces charcoal and tar and is accompanied by the release of volatiles. Various parameters like wood composition, structure, heating rate, and residence time affect the overall yield and composition of these volatiles. Degradation of wood typically starts at 200 °C, but higher temperatures of 450–600 °C are typically used in industrial pyrolysis applications. During this process, complex reactions lead to the formation of characteristic volatiles that are of specific interest for the flavor industry. Within this study, we investigated the formation of aroma components produced by heating beech wood to 300 °C; this is in contrast to European Union flavor legislation where only temperatures below 240 °C are permissible. Therefore, a fingerprint analysis using comprehensive gas chromatography-mass spectrometry (GC×GC-MS) to qualitatively describe and conventional GC-MS to quantitatively describe the release of aroma components by thermal degradation in an oxygen-free atmosphere at 180 °C, 230 °C, and 300 °C was performed. The results were compared with other ligneous biomass of hickory, oak, bamboo, corn, and straw.
Is Adipose Tissue a Place for Mycobacterium tuberculosis Persistence? (2006)

Given the abundance and the wide distribution of the adipose tissue throughout the body, our results suggest that this tissue, among others, might constitute a vast reservoir where the tubercle bacillus could persist for long periods of time, and avoid both killing by antimicrobials and recognition by the host immune system. In addition, M. tuberculosis-infected adipocytes might provide a new model to investigate dormancy and to evaluate new drugs for the treatment of persistent infection.
A low-power four-transistor SRAM cell with a stacked vertical poly-silicon PMOS and a dual-word-voltage scheme (2005)

To realize high-density SRAMs, we developed a four-transistor SRAM cell with a newly developed stacked vertical poly-silicon PMOS. The vertical poly-silicon PMOS has a gate surrounding a body that forms a channel and yields a drive current of 20 /spl mu/A at 25/spl deg/C. Vertical poly-silicon PMOSs are used as transfer MOSs and are stacked over the bulk NMOSs, used as driver MOSs, to reduce the size of a four-transistor SRAM cell. As a result, the size of the proposed four-transistor SRAM cell was 38% of that of a six-transistor SRAM cell. We also developed an electric-field-relaxation scheme to reduce cell leakage and a dual-word-voltage scheme to improve cell stability. By applying these two schemes to the proposed four-transistor SRAM cell, we achieved a 90% reduction in cell leakage and an improvement in cell stability.