gebhart/patrepeval huggingface dataset:
Thermodynamic studies into a sorption mechanism within the cross-linked polysiloxane stationary phases (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermodynamic studies into a sorption mechanism within the cross-linked polysiloxane stationary phasesMichal. Roth, Josef. Novak, Paul. David, and Milos. NovotnyCite this: Anal. Chem. 1987, 59, 11, 1490–1494Publication Date (Print):June 1, 1987Publication History Published online1 May 2002Published inissue 1 June 1987https://pubs.acs.org/doi/10.1021/ac00138a003https://doi.org/10.1021/ac00138a003research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hypoxia-Selective Antitumor Agents. 9. Structure-Activity Relationships for Hypoxia-Selective Cytotoxicity among Analogs of 5-[N,N-Bis(2-chloroethyl)amino]-2,4-dinitrobenzamide (1994)

A series of analogues of the novel hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide (6) have been prepared and evaluated, in a search for compounds which retain high hypoxic selectivity but have increased potency and/or aqueous solubility. Several analogues with ionizable or dipolar carboxamide side chains showed improved solubility but generally had reduced cytotoxic potency and hypoxic selectivity. Modification of the mustard leaving groups or replacement of the carboxamide moiety provided some compounds with superior potency, but only the mixed chloro/mesylate mustard 20 provided a gain in potency relative to solubility while retaining the hypoxic selectivity of 6. These nitrogen mustards did not show the remarkable activity demonstrated by the related aziridine 7 [CB 1954, 5-(N-aziridinyl)- 2,4-dinitrobenzamide] in Walker 256 adenocarcinoma cells and are not efficient substrates for the DT-diaphorase which activates the latter compound by aerobic nitroreduction in Walker cells. Variations in hypoxic selectivity within the dinitrobenzamide mustards appear not to be due to differences in sensitivity to activation by this enzyme. Walker cells showed intermediate sensitivity to the mono(2-chloroethyl) analogue 26 but not to the related half-mustard 27, suggesting that the inhibition of DT-diaphorase activity is due to steric effects in the 5-position. The preferred compound overall with respect to solubility, potency, and in vitro hypoxic cell selectivity was the (dimethylamino)-ethyl derivative 11. DNA elution studies and comparison of the sensitivity of AA8 and UV4 cells to this compound indicated reductive activation to form a DNA cross-linking agent under hypoxia. Radiobiological studies indicated 11 to be equally active against both aerobic and hypoxic cells in KHT tumors. It is not clear whether this reflects efficient killing of aerobic cells as a result of diffusion of reduced metabolites from hypoxic regions or whether cytotoxicity in tumors is independent of hypoxia.
Towards a SFP+ module for WDM applications using an ultra-widely-tunable high-speed MEMS-VCSEL (2017)

In this work, we have used a tunable VCSEL for high-speed optical data transmission. To obtain wide tunability, a MEMS-DBR is surface micromachined onto a short-cavity high-speed VCSEL operating at 1550 nm. Ultra-wide continuous tuning is realized with electro-thermal actuation of the MEMS with built-in stress gradient within SiO<sub>x</sub>/SiN<sub>y</sub> dielectric layers. The MEMS-VCSEL operates in single-mode with SMSR &gt; 40 dB across the entire tuning range. Quasi-error-free transmission of direct-modulation at record 15 Gbps is reported for 20 nm tuning, showing the potential towards the standard requirements for the SFP+ modules in the tail-ends of the WDM transmission system.
Control of Volatile Organic Compounds by the Catalytic Reverse Process (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTControl of Volatile Organic Compounds by the Catalytic Reverse ProcessYurii Sh. Matros and Grigori A. BunimovichCite this: Ind. Eng. Chem. Res. 1995, 34, 5, 1630–1640Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/ie00044a016https://doi.org/10.1021/ie00044a016research-articleACS PublicationsRequest reuse permissionsArticle Views182Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract 862: Negative cellular outcomes following acute in vivo Vhl inactivation in mice (2022)

Abstract Clear cell renal cell carcinoma (ccRCC) is driven by the biallelic inactivation of the von Hippel Lindau tumor suppressor (VHL) gene, which results directly in the normoxic stabilization of hypoxia inducible factors (HIF-1 and -2). While VHL is expressed ubiquitously, its inactivation is tumorigenic only in specific tissues. We hypothesize that this tissue-specificity arises from a negative selective pressure on VHL KO cells that is tolerated in certain contexts. To assess this phenomenon, we induced Vhl deletion in vivo simultaneously across the mouse body and observed cell fate with single-cell resolution. Here we show that inducing widespread inter-organ Vhl deletion results in a massive removal of affected cells from tissue. Our study required technology that allowed us to visualize and isolate Vhl-recombined cells from tissue. For this, we developed a novel lineage marking model in which Cre-mediated excision of Vhl is coupled to knock-in of a tdTomato reporter cassette under the endogenous Vhl promoter. We used this model in conjunction with the ubiquitously-expressed UBC-CreERT2 to induce marked biallelic (KO/KO) or monoallelic (wt/KO) inactivation of Vhl. One week after inactivation was induced by administration of tamoxifen, there were equal numbers of tdTomato-positive cells in both genotypes, implying that initial recombination was similar and that Vhl KO did not affect immediate cell survival. Surprisingly, there was a massive reduction in the number of tdTomato-positive cells in multiple KO/KO organs after four weeks. This loss was accompanied by proliferation of tdTomato-negative cells, as assayed by BrdU incorporation, suggesting that tissues can at least partially compensate for loss of Vhl-inactivated cells. Finally, we found that the removal of cells was preceded by signs of cellular damage and stress, such as accumulation of p27, cytoplasmic translocation of HMGB1, and TUNEL-positivity in the kidney and liver. Taken together, we conclude that Vhl inactivation is inherently deleterious to cells and entrains a negative cell selection process in multiple organs. One corollary is that there must exist some conditions under which such selection might not occur; secondary mutations found in ccRCC, such as in Pbrm1, or loss of individual HIF isoforms, might provide such conditions to Vhl KO cells. Currently we are investigating the role of these additional perturbations in modifying the cellular response to Vhl loss. Our study will provide new insights into the genesis of ccRCC by redefining the mechanisms underlying the creation of pro-tumorigenic niches following Vhl inactivation. Citation Format: Samvid Kurlekar, Joanna D C Lima, Chris W. Pugh, Julie Adam, Peter J. Ratcliffe. Negative cellular outcomes following acute in vivo Vhl inactivation in mice [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 862.
Cup-shaped copper heat spreader in multi-chip high-power LEDs application (2012)

In this study, cup-shaped copper sheets were developed to improve heat dispassion for high-power light emitting diodes (LEDs) array module (3 × 3, 4 × 4, and 5 × 5) using an electroplating technique. The cup-shaped copper sheets were directly contacted with sapphire to enhance the heat dissipation of the chip itself. The lateral emitting light extraction and heat dissipation of high-power LEDs were enhanced and efficient. The surface temperature was not only decreasing but also uniform for each LED chip with the cup-shaped copper heat spreader adoption. The high thermal transmitting performance of cup-shaped copper heat spreader allows thermal resistance reducing 0.7, 0.6, and 0.7 K/W of 3 × 3, 4 × 4, and 5 × 5 LED array module, respectively. In addition, the light output power was increased of 14, 13, and 12% with 3 × 3, 4 × 4, and 5 × 5 LEDs array module using cup-shaped copper sheet at high current injection. High heat dissipation performance and light extraction were obtained by cup-shaped copper sheet with copper bulk and silver mirror.
Convalescent Plasma Use in the United States was inversely correlated with COVID-19 Mortality: Did Plasma Hesitancy cost lives? (2021)

A strong inverse correlation between CCP use and mortality per admission in the USA provides population level evidence consistent with the notion that CCP reduces mortality in COVID-19 and suggests that the recent decline in usage could have resulted in excess deaths.
Photochemistry of 2,2,4,4-Tetramethyl-3-thietan-1-ylidene:  A Heterocyclic Carbene with an Unusually Short Lifetime and Evidence for a Nonclassical Structure (2001)

Laser flash (308 nm) and steady-state photolysis (300 nm) of Δ3-1,3,4-oxadiazoline (3) produces a transient that can be trapped with pyridine to give an adduct with λmax = 350 nm, attributed to ylide 10. Laser flash photolysis (LFP) studies of the ylide indicate that the value of kpyrτ (where kpyr is the absolute rate constant of carbene reaction with pyridine and τ is the carbene lifetime) of the reactive intermediate is 25 times smaller than that deduced for cyclobutylidene. The sulfur-containing transient may have a much shorter lifetime than cyclobutylidene or a much smaller value of kpyr. These experimental results, along with ab initio calculations, suggest that the structure of 2,2,4,4-tetramethyl-3-thietan-1-ylidene is best represented as nonclassical, bisected structure 2 and not classical structure 1.
Two Level Controller for Liquid Nitrogen Supply and Its Application. (1992)

With an additional circuit and a comparator of an OP Amplifier, two-level controller keeping the liquid nitrogen between an upper and a lower level was developed. A commercial Si diode was shown to be able to be used as a level sensor with good interchangeability, high speed response and 300°C heat resistance. A liquid nitrogen supply system of the controller and an auto pressurized vessel was constructed. The system could supply stably and reliably to a sorption pump even when consumption of liquid nitrogen was not constant at cooling down from room temperature.
Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus (2021)

The subthalamic nucleus (STN) is theorized to globally suppress movement through connections with downstream basal ganglia structures. Current theories are supported by increased STN activity when subjects withhold an uninitiated action plan, but a critical test of these theories requires studying STN responses when an ongoing action is replaced with an alternative. We perform this test in subjects with Parkinson's disease using an extended reaching task where the movement trajectory changes mid-action. We show that STN activity decreases during action switches, contrary to prevalent theories. Furthermore, beta oscillations in the STN local field potential, which are associated with movement inhibition, do not show increased power or spiking entrainment during switches. We report an inhomogeneous population neural code in STN, with one sub-population encoding movement kinematics and direction and another encoding unexpected action switches. We suggest an elaborate neural code in STN that contributes to planning actions and changing the plans.
Mercury Liquid Metal Embrittlement Testing of Oil and Gas Production Alloys (2014)

Abstract A test program was again established to evaluate the susceptibility of various metallic materials to liquid metal embrittlement (LME) by mercury using: 1) slow strain rate testing (SSRT) in mercury for screening and 2) fitness for service testing based on constant deflection testing (4-point bend) in a simulated service environment. Materials tested included 3.5% Nickel steel (UNS K32018), 17-4PH (UNS S17400), and 304 stainless steel (UNS S30400). UNS K32018 did not demonstrate significant Hg-LME in SSRT screening. UNS S17400 and UNS S30400 showed significant and moderate Hg-LME susceptibility, respectively, in SSRT screening, but both alloys passed the 4-point bend testing. These results indicate the value of testing using both a screening and fitness for service methodology as the constant load fitness for service testing can more accurately define the stress level of LME susceptibility.
Functional Outcomes of Arthroscopic Capsular Release of the Elbow (2006)

Level IV.
Inverter device nonlinearity characterization technique for use in a motor drive system (2014)

This paper introduces a detailed nonlinearity characterization technique for insulated-gate bipolar transistor inverters in a drive system which is able to measure device nonlinearities. Methods are derived from measurements of the voltage on the inverter phases. These measurements are obtained while applying a set of direct currents to an electrical machine. These methods are then applied to tests using alternating current. The study of inverter nonlinearities is useful in order to improve controller accuracy, implement sensorless controllers, and conduct condition monitoring. These methods fulfill the need to characterize each device in an inverter. In addition to characterizing every device using either AC or DC current, the method is resistant to noise; for these reasons the method is applicable in the field. Simulations and experimental work demonstrate the benefits and applicability of the methods.
Electron Interferometry at Crystal Surfaces (1985)

Electron standing waves formed in the vacuum gap between the probe and the sample of the tunneling microscope are observed. The sensitivity of the standing-wave positions and frequencies to the surface potential are demonstrated. Further effects possibly due to Bragg backscattering from the surface atomic planes of the sample are discussed.
Radiographic Workup of Spinal Cord Injury (2007)

This chapter contains section titled: Introduction Conventional radiology Spinal CT Spinal MRI Cervical spine injuries Thoracolumbar spine injuries Future of the radiological evaluation of SCI
Prediction of Video Popularity in the Absence of Reliable Data from Video Hosting Services: Utility of Traces Left by Users on the Web (2016)

With the growth of user-generated content, we observe the constant rise of the number of companies, such as search engines, content aggregators, etc., that operate with tremendous amounts of web content not being the services hosting it. Thus, aiming to locate the most important content and promote it to the users, they face the need of estimating the current and predicting the future content popularity. In this paper, we approach the problem of video popularity prediction not from the side of a video hosting service, as done in all previous studies, but from the side of an operating company, which provides a popular video search service that aggregates content from different video hosting websites. We investigate video popularity prediction based on features from three primary sources available for a typical operating company: first, the content hosting provider may deliver its data via its API, second, the operating company makes use of its own search and browsing logs, third, the company crawls information about embeds of a video and links to a video page from publicly available resources on the Web. We show that video popularity prediction based on the embed and link data coupled with the internal search and browsing data significantly improves video popularity prediction based only on the data provided by the video hosting and can even adequately replace the API data in the cases when it is partly or completely unavailable.
Cystic Fibrosis–Related Diabetes Workshop: Research Priorities Spanning Disease Pathophysiology, Diagnosis, and Outcomes (2023)

Cystic fibrosis (CF) is a recessive disorder arising from mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR is expressed in numerous tissues, with high expression in the airways, small and large intestine, pancreatic and hepatobiliary ducts, and male reproductive tract. CFTR loss in these tissues disrupts regulation of salt, bicarbonate, and water balance across their epithelia, resulting in a systemic disorder with progressive organ dysfunction and damage. Pancreatic exocrine damage ultimately manifests as pancreatic exocrine insufficiency that begins as early as infancy. Pancreatic remodeling accompanies this early damage, during which abnormal glucose tolerance can be observed in toddlers. With increasing age, however, insulin secretion defects progress such that CF-related diabetes (CFRD) occurs in 20% of teens and up to half of adults with CF. The relevance of CFRD is highlighted by its association with increased morbidity, mortality, and patient burden. While clinical research on CFRD has greatly assisted in the care of individuals with CFRD, key knowledge gaps on CFRD pathogenesis remain. Furthermore, the wide use of CFTR modulators to restore CFTR activity is changing the CFRD clinical landscape and the field's understanding of CFRD pathogenesis. For these reasons, the National Institute of Diabetes and Digestive and Kidney Diseases and the Cystic Fibrosis Foundation sponsored a CFRD Scientific Workshop, 23-25 June 2021, to define knowledge gaps and needed research areas. This article describes the findings from this workshop and plots a path for CFRD research that is needed over the next decade.
On the peak-to-average power ratio of M-sequences (2003)

The paper derives an expression for the peak-to-average power ratio (more exactly the peak-to-mean envelope power ratio) of an M-sequence. The derived parameter is of crucial importance if M-sequences are used in multi-carrier communication systems (e.g. OFDM).
High Brightness ZnS and GaN Electroluminescent Devices Using PZT Thick Dielectric Layers (2005)

An improved thick dielectric (TD) layer for inorganic electroluminescent (EL) display devices has been achieved through a composite high-/spl kappa/ dielectric sol-gel/powder route. This composite TD film results in a luminance improvement (up to 10/spl times/) in these TDEL devices with Eu-doped GaN and Mn-doped ZnS phosphor layers. The use of a composite TD film, composed primarily of lead-zirconate-titanate (PZT), results in a significantly higher charge (>3 /spl mu/C/cm/sup 2/) coupling to the phosphor layer. Furthermore, the reduction in porosity of the TD has improved the homogeneity of electric field applied to the phosphor layer, resulting in a steeper luminance-voltage slope. The reduction in porosity has also decreased the diffuse reflection of the TD, which when pigmented, exhibits a diffuse reflectivity of <2% resulting in high display contrast. High luminance levels of up to 3500 cd/m/sup 2/ have been achieved from the ZnS:Mn TDEL devices and 450 cd/m/sup 2/ from GaN:Eu devices. A detailed analysis of the electrical steady-state time-varying characteristics has shown that the electrical performance of TDELs is very similar to TFELs in spite of the physical asymmetry in the device structure. These results demonstrate that three critical requirements for practicality of the TDEL approach (formation on standard display glass, low reflectivity, and electric field homogeneity) can be obtained by careful selection and design of the device materials, fabrication process and device structure.
Protein‐Induced Color Shift of Carotenoids in β‐Crustacyanin (2015)

β-Crustacyanin (β-CR) is a pigment protein responsible for the blue color of lobsters. We show using correlated ab initio calculations how the protein environment tunes the chromophores of β-CR through electrostatic and steric effects.
On Shared Risk Link Group Optimization [Invited] (2012)

Shared risk link groups (SRLGs) have been defined and implemented in many network planning tools and routing protocols. A single SRLG represents one potential failure, and a large service provider&#x2019;s network could easily contain tens of thousands of potential failures. The greater the number of SRLGs, the more difficult it is to attain good performance from planning tools (like routers) whose computations are dependent on the number of SRLGs. For many routing protocols using SRLG information, the situation becomes even worse, because a routing protocol may have space constraints to hold a limited number of SRLGs. These issues create a challenge to optimize the SRLG calculations such that the SRLG-related functions are not impacted or the impacts on the SRLG-related functions are limited. This paper takes a closer look at the SRLG optimization issue and identifies the facts/observations of SRLGs. Then we propose algorithms for how to reduce the number of SRLGs for different applications based on our observations.
Inline myocardial t2* mapping with iterative robust fitting (2011)

Myocardial T2* measurement is a valuable tool for non-invasive assessment of iron overload, and is clinically employed for planning and monitoring iron-chelating treatments for transfused thalassemia major patients [1]. Presently, for T2* assessment, dark-blood prepared gradient echo (GRE) images are acquired at multiple echo times (TEs). Thereafter, these images are analyzed within offline software such as CMRTools:ThalassaemiaTools®, in which the septal signal of a full thickness ROI is fitted to a monoexponential decay curve to estimate myocardial T2* [2]. The goal of this study was to develop and test a T2* measurement technique with automated inline T2*-map generation. Availability of such a technique on commercial MR systems may further utilization of such measurements in this patient group.