gebhart/patrepeval huggingface dataset:
Transcription Factors Analysis in Neuronal-Like Cells Derived from Adult Human Bone Marrow. (2004)

Abstract Stem cells are immature cells with self-renewal capacity and ability to differentiate into multiple cell types including bone, cartilage, fat, tendon and muscle. Transplantation of stem cells or their derivatives to the adult brain have been proposed as future therapy for neurodegenerative diseases. Parkinson’s disease (PD) is a progressive neurodegenerative disease involving the deterioration of dopaminergic neurons of the substantia nigra, a part of the midbrain. Most of the currently used drugs are based on dopamine replacement which, although it reduces symptoms is limited owing to severe side effects. Alternatively, strategies of cell therapy for the treatment of PD focused on replacing damaged neurons with cells that may improve the functioning of the damaged cell population. In this study, we demonstrate that bone marrow stromal cells isolated from human iliac crest can be induced to differentiate into neural-like cells. Human bone marrow stromal cells differentiation was induced with N2 supplements, retinoic acid, butylated hydroxyanisole, isobutylmethylxanthine and dibutyryl-cyclic-AMP. A few hours after differentiation the cells changed their phenotype to neural-like cells, spindle shaped, with cell bodies and long branches. Moreover, immunostaining demonstrated the expression of specific neuronal markers such as nestin, neurofilaments and neuron specific enolase. To define the transcription factors associated with the differentiation, we used the TranSignal Protein/DNA kit (Panomics Inc). This new array-based technology allows functional analysis of dozens of eukaryotic transcription factors. Nuclear proteins were purified and incubated with mix labeled DNA binding oligonucleotides corresponding to the consensus sequences of 96 transcription factors. The DNA probes were then dissociated from the complexes and used to hybridize the TranSignal Array. We found that the differentiated human bone marrow stromal cells induced the expression of several neuron-specific transcription factors such as GAG (glycosaminoglycan), FKHR (human forkhead in rhabdomyosarcoma) and DR-2. The activation of these transcription factors in a time course manner was evident also by electrophoretic mobility shift assay. In conclusion, we show that the induced differentiation of neuronal like cells from bone marrow is associated with activation of specific neuronal transcription factors. Our study advances the possible use of autologous transplantation as a new strategy for cell therapy in neurodegenerative diseases.
Unusual Pseudogap Features Observed in Iron Oxypnictide Superconductors (2008)

We have performed a temperature-dependent angle-integrated laser photoemission study of iron oxypnictide superconductors LaFeAsO:F and LaFePO:F exhibiting critical transition temperatures (Tc's) of 26 K and 5 K, respectively. We find that high-Tc LaFeAsO:F exhibits a temperature-dependent pseudogap-like feature extending over ~0.1 eV about the Fermi level at 250 K, whereas such a feature is absent in low-Tc LaFePO:F. We also find ~20-meV pseudogap-like features and signatures of superconducting gaps both in LaFeAsO:F and LaFePO:F. We discuss the possible origins of the unusual pseudogap-like features through comparison with the high-Tc cuprates.
Effects of married migrant women's social participation upon marital satisfaction: Mediating variable of acculturative stress (2017)

This study investigated effects of married migrant women's social activity participation with mediating variable of acculturative stress. The subject was 364 married migrant women at Seoul and Gyeonggi-do. The respondents were given questionnaire to answer for 38 days from December 20, 2016 to January 26, 2017. SPSS 23.0 was used. Exploratory factor analysis was done to increase internal appropriateness, and Cronbach's α was used to investigate internal consistency, and Pearson's correlation analysis was done to investigate relation between participation in the society, cultural adaptation stress and marital satisfaction. Three stage regression was used to investigate mediating effect of cultural adaptation stress at the effect of social activity participation upon marital satisfaction (Baron and Kenny(1986)), and Sobel test was conducted to verify significance of mediating effect. Married migrant women's social activity participation had significant influence upon marital satisfaction, and social activity participation has significant influence upon cultural adaptation stress. Not only social activity participation but also cultural adaptation stress was used at the same time to have significant influence upon marital satisfaction and to have partial mediating effect of cultural adaptation stress. This study conduct exploratory analysis upon married migrant women's social activity participation and cultural adaptation stress to give implications of less divorce of multi-cultural family and higher marital satisfaction.
Multisite Thrombus Imaging and Fibrin Content Estimation With a Single Whole-Body PET Scan in Rats (2015)

We demonstrated that (64)Cu-FBP8-PET is a feasible approach for whole-body thrombus detection and that molecular imaging of fibrin can provide, noninvasively, insight into clot composition.
Immunological Characterization of a Protective Antigen of Erysipelothrix rhusiopathiae : Identification of the Region Responsible for Protective Immunity (1999)

The gene encoding a protective protein antigen of the gram-positive bacterium Erysipelothrix rhusiopathiae, an important veterinary pathogen responsible for erysipelas in swine and a variety of diseases in animals, was cloned and sequenced. The gene encodes a polypeptide of 597 amino acids plus a putative signal sequence of 29 amino acids, resulting in a mature protein with a molecular mass of 69,017 Da. Sequence analysis of the gene product revealed a C-terminal region composed of nine tandem repeats of 20 amino acids and a total sequence that is nearly identical to that of the 64-kDa cell surface protein (SpaA) of the bacterium. Because of this similarity, the protein was designated SpaA.1. In this study, we examined whether the SpaA.1 protein could induce protective antibodies and whether we could identify the region involved in protective immunity. Both the mature SpaA.1 protein and its C-terminal repeat region, but not the N-terminal segment, were expressed in Escherichia coli and purified as a histidine-tagged fusion recombinant protein. Rabbit antiserum raised against the mature SpaA.1 protein passively protected mice from lethal challenge with a virulent homologous strain, Fujisawa-SmR, suggesting that protection is mediated by humoral antibodies. To determine which domain of the SpaA.1 protein is responsible for the observed protection, mice were actively immunized with either the mature SpaA. 1 protein or the C-terminal repeat region and then challenged with Fujisawa-SmR. The result showed that mice immunized with the mature SpaA.1 protein, but not the C-terminal repeat region, were protected, suggesting that the protection-eliciting epitope(s) is located within the N-terminal two-thirds of the SpaA.1 molecule. This was confirmed by passive immunization experiments in which the protective activity of rabbit antiserum, raised against mature SpaA. 1 protein, was not abolished by absorption with the purified recombinant C-terminal repeat region. In addition, antibodies specific for the C-terminal repeat region were unable to protect mice from lethal challenge. These results show that the N-terminal two-thirds of the SpaA.1 molecule may constitute a good vaccine candidate against erysipelas.
Fate Dynamics of Environmentally Exposed Explosive Traces (2012)

The chemical and physical fates of trace amounts (<50 μg) of explosives containing 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and pentaerythritol tetranitrate (PETN) were determined for the purpose of informing the capabilities of tactical trace explosive detection systems. From these measurements, it was found that the mass decreases and the chemical composition changes on a time scale of hours, with the loss mechanism due to a combination of sublimation and photodegradation. The rates for these processes were dependent on the explosive composition, as well as on both the ambient temperature and the size distribution of the explosive particulates. From these results, a persistence model was developed and applied to model the time dependence of both the mass and areal coverage of the fingerprints, resulting in a predictive capability for determining fingerprint fate. Chemical analysis confirmed that sublimation rates for TNT were depressed by UV (330-400 nm) exposure due to photochemically driven increases in the molecular weight, whereas the opposite was observed for RDX. No changes were observed for PETN upon exposure to UV radiation, and this was attributed to its low UV absorbance.
Annexin A2 Regulates A Disintegrin and Metalloproteinase 17–mediated Ectodomain Shedding of Pro–Tumor Necrosis Factor-α in Monocytes and Colon Epithelial Cells (2013)

ANX A2 was closely associated with ADAM17 and played an important role in TNF-α shedding by TPA. Inhibition of ANX A2 might be a new therapeutic strategy for prevention of TNF-α shedding during inflammatory bowel disease inflammation.
Electronics on plastic: A solution to the energy challenge, or just a pipe dream? (2007)

For over 50 years, conjugated organic compounds have been recognized as an important class of electronic semiconductor materials, with potential application to light emission and detection. Very recently, these materials have been shown to generate extremely high efficient white light, and can also have high detection efficiencies. Due to their very low cost and low deposition temperatures, this suggests that organic thin film semiconductor light emitting diodes and solar cells may present a practical solution to mankind's greatest challenge: the use and generation of low cost renewable, and largely pollution free energy. In this talk, I will address both the reality and fantasy of this suggestion. While organic thin film devices can have extremely high performance, they also suffer from shorter operational lifetime than conventional semiconductor (e.g. silicon) devices. And, although their low cost has yet to be proven in large scale manufacturing environments, the potentially unlimited promise of this materials class is driving a substantial global research effort to determine their ultimate applicability to meeting our energy challenges.
Data from Immunotherapy of Ipilimumab and Nivolumab in Patients with Advanced Neuroendocrine Tumors: A Subgroup Analysis of the CA209-538 Clinical Trial for Rare Cancers (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Combination immunotherapy with anti–CTLA-4 and anti–PD-1 blockade has demonstrated significant clinical activity across several tumor types. Neuroendocrine tumors (NET) are a heterogeneous group of rare tumors with limited treatment options. CA209-538 is a clinical trial of combination immunotherapy with ipilimumab and nivolumab in rare cancers, including advanced NETs.&lt;/p&gt;Patients and Methods:&lt;p&gt;CA209-538 is a prospective multicenter clinical trial in patients with advanced rare cancers. Patients received treatment with nivolumab at a dose of 3 mg/kg and ipilimumab at 1 mg/kg every three weeks for four doses, followed by nivolumab 3 mg/kg every two weeks and continued for up to 96 weeks, until disease progression or the development of unacceptable toxicity. Response was assessed every 12 weeks by RECIST 1.1. The primary endpoint was clinical benefit rate (CBR; complete remission + partial remission + stable disease).&lt;/p&gt;Results:&lt;p&gt;Twenty-nine patients with advanced NETs received treatment. Three (10%) patients had low-, 13 (45%) had intermediate-, and 13 (45%) had high-grade tumors; lung was the most common primary site (39%). The objective response rate was 24% with a CBR of 72%; 43% of patients with pancreatic neuroendocrine neoplasms (NEN), and 33% of patients with atypical bronchial carcinoid achieved an objective response. The median progression-free survival was 4.8 months [95% confidence interval (CI): 2.7–10.5] and overall survival was 14.8 months (95% CI: 4.1–21.3). Immune-related toxicity was reported in 66% of patients with 34% experiencing grade 3/4 events.&lt;/p&gt;Conclusions:&lt;p&gt;Combination immunotherapy with ipilimumab and nivolumab demonstrated significant clinical activity in subgroups of patients with advanced NETs including patients with atypical bronchial carcinoid and high-grade pancreatic NENs.&lt;/p&gt;&lt;/div&gt;
Acoustic effect and the polarization of adjacent bits in soliton communication lines (1994)

The excitation of radial and torsional-radial acoustic modes by solitons is analyzed depending on light polarization. The theoretical study of the timing jitter and bit error rate caused by the acoustic effect in soliton communication lines for co- and counter-polarized adjacent bits is presented. The influence of guiding filter on the acoustically induced timing jitter is calculated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Anneal-Induced Degradation of Amorphous Selenium Characterized by Photoconductivity Measurements (2005)

Photoconductivity measurements of amorphous selenium (a-Se) and arsenic selenide (a-As 2 Se 3 ) were carried out. Samples where annealed from 333–358 K at 5 K step for 5 minutes and the photoconductivity was measured after each annealing step. It was found that the dark current increases permanently for a-Se and the photoconductivity ratio increased drastically after 338 K, but drops after further annealing. Amorphous-As 2 Se 3 however, has no noticeable change in the dark current neither in the photoconductivity ratio. Arsenic is introduced into a-Se to prevent degradation, which causes loss of image quality, but the volume must be controlled in order to maintain high photoconductivity.
Throughput and latency programmable optical transceiver by using DSP and FEC control (2017)

We propose and experimentally demonstrate a proof-of-concept of a programmable optical transceiver that enables simultaneous optimization of multiple programmable parameters (modulation format, symbol rate, power allocation, and FEC) for satisfying throughput, signal quality, and latency requirements. The proposed optical transceiver also accommodates multiple sub-channels that can transport different optical signals with different requirements. Multi-degree-of-freedom of the parameters often leads to difficulty in finding the optimum combination among the parameters due to an explosion of the number of combinations. The proposed optical transceiver reduces the number of combinations and finds feasible sets of programmable parameters by using constraints of the parameters combined with a precise analytical model. For precise BER prediction with the specified set of parameters, we model the sub-channel BER as a function of OSNR, modulation formats, symbol rates, and power difference between sub-channels. Next, we formulate simple constraints of the parameters and combine the constraints with the analytical model to seek feasible sets of programmable parameters. Finally, we experimentally demonstrate the end-to-end operation of the proposed optical transceiver with offline manner including low-density parity-check (LDPC) FEC encoding and decoding under a specific use case with latency-sensitive application and 40-km transmission.
High-speed particle tracking in microscopy using SPAD image sensors (2018)

Single photon avalanche diodes (SPADs) are used in a wide range of applications, from fluorescence lifetime imaging microscopy (FLIM) to time-of-flight (ToF) 3D imaging. SPAD arrays are becoming increasingly established, combining the unique properties of SPADs with widefield camera configurations. Traditionally, the photosensitive area (fill factor) of SPAD arrays has been limited by the in-pixel digital electronics. However, recent designs have demonstrated that by replacing the complex digital pixel logic with simple binary pixels and external frame summation, the fill factor can be increased considerably. A significant advantage of such binary SPAD arrays is the high frame rates offered by the sensors (&gt;100kFPS), which opens up new possibilities for capturing ultra-fast temporal dynamics in, for example, life science cellular imaging. In this work we consider the use of novel binary SPAD arrays in high-speed particle tracking in microscopy. We demonstrate the tracking of fluorescent microspheres undergoing Brownian motion, and in intra-cellular vesicle dynamics, at high frame rates. We thereby show how binary SPAD arrays can offer an important advance in live cell imaging in such fields as intercellular communication, cell trafficking and cell signaling.
Design of a HomePNA 2.0 MAC Controller Circuit (2007)

The home phoneline networking alliance (HomePNA) 2.0 technology can establish a home network using existing in-home phone lines and provides a channel rate of 4 - 32 Mbps. The HomePNA 2.0 medium access control (MAC) protocol adopts an IEEE 802.3 carrier sense multiple access with collision detection (CSMA/CD) access method, a quality of service (QoS) algorithm, and a distributed fair priority queuing (DFPQ) collision resolution algorithm. In this paper, we analyze the HomePNA 2.0 MAC protocol, propose an architecture of the HomePNA 2.0 MAC controller circuit, and show the simulation results of each block included in the HomePNA 2.0 MAC controller.
Performance of Silicon Carbide PiN Diodes Fabricated on Basal Plane Dislocation-Free Epilayers (2006)

The nucleation sites of stacking faults (SFs) during forward current stress operation of 4H-SiC PiN diodes were investigated by the electron beam induced current (EBIC) mode of scanning electron microscopy (SEM), and the primary SF nucleation sites were found to be basal plane dislocations (BPDs). Damage created on the diode surface also acts as SF nucleation sites. By using a novel BPD-free SiC epilayer, and avoiding surface damage, PiN diodes were fabricated which did not exhibit SF formation under current stressing at 200A/cm2 for 3 hours.
Ferromagnetic-metal-based InGaAs(P)/InP optical waveguide isolator: steps towards experimental validation (2002)

We have explored three key aspects which are crucial to demonstrate an InP-based isolator with ferromagnetic contacts: the ohmic behaviour of the FeCo-semiconductor contact, the active layer with high TM-gain, and the magnetooptic behaviour of FeCo at 1.55 /spl mu/m.
A convenient synthesis of poly[sulfonylmethylene‐1,4‐phenylenemethylene] directly from sulfur dioxide (1980)

Abstract Poly[sulfonylmethylene‐1,4‐phenylenemethylene] ( 2 ) was obtained from 4‐chloromethylbenzyl chloride ( 1 ), potassium and sulfur dioxide by using 1,4,7,10,13,16‐hexaoxacyclooctadecane (18‐crown‐6‐ether) as catalyst. On the other hand, the reaction of 1 , potassium and sulfur dioxide in the absence of 18‐crown‐6‐ether gave preferentially poly[1,4‐phenyleneethylene] ( 3 ) by the Wurtz reaction between 1 and potassium. A detailed study was carried out on these reactions.
Augmentation of Dilated Failing Left Ventricular Stroke Work by a Physiological Cardiac Assist Device (2004)

A novel physiological cardiac assist device (PCAD), otherwise known as the LEVRAM assist device, which is synchronized with the heartbeat, was developed to assist the left ventricle (LV) in chronic heart failure (CHF). The PCAD utilizes a single cannula, which is inserted in less than 15 s through the apex of the beating LV by means of a specially designed device. Blood is withdrawn from the LV into the PCAD in diastole and is injected back to the LV, through the same cannula, during the systolic ejection phase, thereby augmenting stroke volume (SV) and stroke work (SW). CHF with dilated LV was induced in sheep by successive intracoronary injections of 100-microm beads. The sheep (92.2 +/- 25.9 kg, n = 5) developed stable CHF with increased LV end-diastolic diameter (69.4 +/- 3.3 mm) and end-diastolic volume (LVEDV = 239 +/- 32 mL), with severely reduced ejection fraction (23.8 +/- 7.6%), as well as mild-to-moderate mitral regurgitation. The sheep were anesthetized, and the heart was exposed by left thoracotomy. Pressure was measured in the LV and aorta (Millar). The SV was measured by flow meters and the LV volume by sonocrystals. Assist was provided every 10 regular beats, and the assisted beats were compared with the preceding unassisted beats, at the same LVEDV. The PCAD displaced 13.6 +/- 3.4 mL, less than 8% of LVEDV. Added SW was calculated from the assisted and control pressure-volume loops. The efficiency, defined as an increase in SW divided by the mechanical work of the PCAD, was 85.4 +/- 16.9%. We conclude that the PCAD, working with a small displaced blood volume in synchrony with the heartbeat, efficiently augments the SW of the dilated failing LV. The PCAD is suggested for use as a permanent implantable device in CHF.
Biphenotypic B / macrophage cells express COX-1 and up-regulate COX-2 expression and prostaglandin E2 production in response to pro-inflammatory signals (1999)

B/macrophage cells are biphenotypic leukocytes of unknown function that simultaneously express B lymphocyte (IgM, IgD, B220, CD5) and macrophage (phagocytosis, F4/80, Mac-1) characteristics. B/macrophage cells can be generated from purified mouse B lymphocytes incubated in fibroblast-conditioned medium. A potential role for B/macrophage cells in inflammation was shown by their ability to express prostaglandin H synthase-1 (COX-1) and prostaglandin H synthase-2 (COX-2) and by their production of prostaglandin (PG) E(2). COX-1 and COX-2 mRNA expression is not observed in the precursor B lymphocytes and is not known to be a property of B lineage cells. In contrast, COX-2 and the prostanoids PGE(2), PGF(2alpha) and PGD(2) are highly inducible in B/ macrophage cells upon stimulation with lipopolysaccharide, CD40 ligand, or via engagement of surface IgM, supporting a role for these cells in inflammation. PGD(2) and its metabolites are of interest because they activate the nuclear receptor PPARgamma that regulates lipid metabolism. The B/macrophage represents the first instance of a normal B-lineage cell capable of expressing COX-2. Importantly, B/macrophage cells were identified in vivo, providing evidence that they may play a significant role in immune responses. Since PGE(2) blunts IL-12 production, its synthesis by B/macrophage cells may shift the balance of an immune response towards Th2 and humoral immunity.
Global processing in amblyopia: a review (2014)

Amblyopia is a neurodevelopmental disorder of the visual system that is associated with disrupted binocular vision during early childhood. There is evidence that the effects of amblyopia extend beyond the primary visual cortex to regions of the dorsal and ventral extra-striate visual cortex involved in visual integration. Here, we review the current literature on global processing deficits in observers with either strabismic, anisometropic, or deprivation amblyopia. A range of global processing tasks have been used to investigate the extent of the cortical deficit in amblyopia including: global motion perception, global form perception, face perception, and biological motion. These tasks appear to be differentially affected by amblyopia. In general, observers with unilateral amblyopia appear to show deficits for local spatial processing and global tasks that require the segregation of signal from noise. In bilateral cases, the global processing deficits are exaggerated, and appear to extend to specialized perceptual systems such as those involved in face processing.
Total Synthesis of the Marine Natural Product (‐)‐Clavosolide A: Showcase for the Petasis—Ferrier Union/Rearrangement Tactic. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.