gebhart/patrepeval huggingface dataset:
Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom (2015)

Most venomous predators have evolved complex venom primarily to immobilize their prey and secondarily to defend against predators. In a new paradigm, carnivorous marine gastropods of the genus Conus were shown to rapidly and reversibly switch between two types of venoms in response to predatory or defensive stimulus, suggesting that the defensive use of venom may have a more important role in venom evolution and specialization than previously thought. To further investigate this phenomenon, the defensive repertoire of a vermivorous species, Conus planorbis, was deciphered using second-generation sequencing coupled to high-throughput proteomics. The venom gland transcriptome of C. planorbis revealed 182 unique conotoxin precursors from 25 gene superfamilies, with superfamily T dominating in terms of read and paralog numbers. Analysis of the defense-evoked venom revealed that this vermivorous species uses a similarly complex arsenal to deter aggressors as more recently evolved fish- and mollusk-hunting species, with MS/MS validating 23 conotoxin sequences from six superfamilies. Pharmacological characterization of the defensive venom on human receptors identified the nicotinic acetylcholine receptors as a primary target. This work provides the first insights into the composition and biological activity of specifically evolved defensive venoms in vermivorous cone snails.
Supplemental Materials and Methods from A PET Imaging Strategy to Visualize Activated T Cells in Acute Graft-versus-Host Disease Elicited by Allogenic Hematopoietic Cell Transplant (2023)

&lt;p&gt;CHO Cell Transfection Tracer Uptake and Efflux Assays for Adherent Cells Western Blot Immunofluorescence Staining of Lymphoid Organs Ex Vivo Donor T Cell Proliferation Analysis Automated preparation of [18F]FAraG for human imaging using the Neptis perform PET synthesizer Imaging Studies in Humans Statistics&lt;/p&gt;
New Hemisynthetic Manoyl Oxide Derivatives with Antimicrobial Activity. (2001)

The synthesis and antimicrobial activity of ten labdane-type diterpenes derived from ent-3-beta-hydroxy-13-epi-manoyl oxide (ribenol) is reported. The chloroethyl carbamidic ester 9 showed the strongest antimicrobial activity against all the tested gram (+), gram (-) bacteria and pathogenic fungi. Moreover, the glycoside 11 exhibited an interesting activity against the three tested fungi.
Channel and complexity scalable image transmission (2002)

We present a source-channel coding system which is well suited for transmission over channels with varying channel states as common in mobile environments or broadcast scenarios. The system consists of a progressive source coder, a high-memory convolutional code (CC) with puncturing for unequal error protection (UEP) and a sequential decoding unit referred to as far end error decoder (FEED). In contrast to the conventional design goal of channel coding systems to minimize the bit error probability the presented system aims on maximizing the contiguously error-free part of the source message. Additionally, FEED allows one to localize the first error in the decoded message and only the virtually error free part is delivered to the source decoder. For image transmission gains up to 1.2 dB in average PSNR can be obtained compared to the best known system with the same channel decoder complexity. Finally, FEED allows a trade-off between receiver complexity and quality.
Visualization of O2 Partial Pressures in Running PEFC With Straight Channels (2013)

Abstract not Available.
Evaluating best practices when interviewing stakeholders during design (2016)

Her research focuses on strategies for design innovations through divergent and convergent thinking
Cancer Associated Fibroblasts Derived from Pancreatic Adenocarcinoma and Their Role in Cell Migration (2021)

CAFs are a key element of intra-tumoral migration and should be further investigated as a potential therapeutic target.
Central nervous system involvement by Waldenström macroglobulinaemia (Bing‐Neel syndrome): a multi‐institutional retrospective study (2015)

Bing-Neel syndrome (BNS) is a rare complication seen in patients with Waldenström macroglobulinaemia (WM), in which lymphoplasmacytic lymphoma cells colonize the central nervous system. In this retrospective multi-centre study, we present the clinicopathological features, imaging findings, therapy, response and outcomes of 34 patients with BNS. The median time from WM diagnosis to BNS diagnosis was 3 years, 15% of patients were diagnosed with BNS at the time of WM diagnosis, and 22% of patients developed BNS when responding to active treatment for WM. Patients with BNS presented with variable clinical features including limb motor deficits, change in mental status and cranial nerve palsies. The diagnosis was made using a combination of cerebrospinal fluid cytology, flow cytometry and detection of the MYD88 L265 mutation, and magnetic resonance imaging. The estimated 3-year overall survival rate was 59%. Of the survivors, 40% have evidence of pathological and/or radiological persistence of disease. Age older than 65 years, platelet count lower than 100 × 10(9) /l, and treatment for WM prior to BNS diagnosis were associated with worse outcome. Exposure to rituximab for treatment of BNS was associated with a better outcome. Multi-institutional collaboration is warranted to improve treatment and outcomes in patients with BNS.
Pilot study of redirected autologous T cells engineered to contain anti-CD19 attached to TCRζ and 4-1BB signaling domains in patients with chemotherapy-resistant or -refractory CD19+ leukemia and lymphoma. (2013)

TPS10072 Background: Outcomes remain poor for patients (pts) with relapsed or refractory (r/r) B-cell malignancies such as acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL). CD19 is an attractive therapeutic target because it is widely expressed on normal and malignant B cells throughout B-cell maturation but not on pluripotent stem cells or non–B-cell tissues. We have developed chimeric antigen receptor T cells to target CD19+ cells (CART-19 or CTL019). This approach involves patient-derived T cells that are genetically modified via lentiviral transduction to express a CD19 antigen recognition domain attached to intracellular signaling domains (TCRζ and 4-1BB) that mediate T-cell activation. A recent study in CLL showed that CART-19 therapy had potent activity with responses in 5/8 evaluable pts (3 CR, 2 PR). Pts achieving CR (two &gt; 24 months and one &gt; 5 months) remain in CR with detectable CART-19 cells (Porter et al. ASH 2012). Here we describe a study of CART-19 therapy in pediatric pts with r/r leukemia and lymphoma (NCT01626495). Methods: Pts eligible for this single-arm, open-label study are aged 1 to 24 years with r/r CD19+ B-cell malignancies, without a transplant option or having relapsed after allogeneic stem cell transplantation (ASCT). Pts will undergo leukapheresis to obtain T cells, which will be stimulated, expanded, and transduced ex vivo to express the chimeric antigen receptor. Pts may receive lymphodepleting chemotherapy prior to CART-19 infusion. Study objectives: determine the safety and feasibility of administering CART-19 therapy to pediatric pts, assess duration of in vivo survival of CART-19 cells, and measure antitumor response. There are 2 cohorts in the study: Cohort 1 includes pts who have not undergone ASCT and are not currently eligible for a transplant, and cohort 2 includes pts who relapsed after ASCT. Cells are collected from the recipient, not the donor, which allows for this approach to be used in pts s/p cord blood transplant, and which we hypothesize will reduce the risk of GVHD as a result of toleration of the T cells in the recipient. To date, 7 pts have been enrolled. Clinical trial information: NCT01626495.
Modeling the Galileo Full Operational Capability (FOC) Transmit Antenna and its Impact on Future Space Missions (2014)

The Global Positioning System (GPS) was originally conceived to provide the United States military with reliable navigation and timing on and close to Earth. By design, the signals broadcast from the GPS satellites are extremely weak when received on Earth. Signal processing in the user receiver boosts the desired signal to power levels at which they can be acquired and tracked. Today, the primary use of the system is for civilian applications.

The use of GPS and upcoming Global Navigation Satellite System (GNSS) signals for Geostationary Orbit (GEO) and Highly Elliptical Orbit (HEO) missions has special design challenges. In these missions, the GPS receiver is at an altitude above the altitude of the GNSS constellations. Consequently, the only signals reaching the receiver at these altitudes originate from satellites on the opposite side of Earth. The received signals are 10 to 100 times weaker with limited satellite spatial diversity. The Navigator GPS Receiver developed at NASA Goddard Space Flight Center is a space grade receiver with fast signal acquisition and weak signal tracking capabilities. Using the GPS constellation alone, rarely are four or more satellites visible simultaneously. This limits the possibility of autonomous navigation at GEO and beyond.

This paper provides results from a systems engineering analysis of upgrading the Navigator to support multiple constellations. Satellite visibility is evaluated for a combined GPS + Galileo constellation. A combined GPS + Galileo system is chosen to leverage the common L1 composite signal without changing existing rad-hard L1 RF frontends. The analysis assumes the same GPS Block III satellite transmit antenna model for the Galileo satellites as well. Starting with the Block III satellites, the mean beam of the transmitted GPS signals would be enhanced to 23.5 degrees (half angle) compared to the current 21.3 degrees. This will improve visibility of the signal main lobe at GEO and beyond. The Galileo Interface Control Document (ICD) does not specify the transmit signal beam width. 

The L1C signal structure allows for lower thresholds compared to the L1 C/A signal. Upgrading the Navigator the support the L1C signal with lower thresholds would significantly improve autonomous navigation in GEO and HEO. At GEO, continuous autonomous navigation is realizable with the combined constellation at current Navigator thresholds. The authors do appreciate the significant implementation challenges in upgrading the receiver. Techniques to achieve lower tracking thresholds for the L1C signal and potential implementation challenges would be addressed in subsequent publications.
Functionalized cyclic carbonates: from synthesis and metal-free catalyzed ring-opening polymerization to applications (2010)

Aliphatic polycarbonates are often referenced for their interesting applications due to their lower tendency to undergo hydrolysis, lower Tg, and their degradation in renewable resources. Their synthesis is described using a series of metal-free catalysts allowing preparation of well-defined polymers in terms of molecular weights and structures. Additionally, some highlights regarding their biomedical applications such as drug targeting are presented.
A Family of Single-Component Tools for Optical Control of Neural Activity (2011)

Members of the microbial opsin gene family have emerged recently as crucial tools for optogenetics, a new neuroscience technology. “Opto genetics” can be defined as the integration of optics and genetics to control well-defined events (such as action potentials) within specified cells (such as a targeted class of projection neurons) in living tissues (such as the brains of freely behaving mammals). In this chapter, we focus on the diversity of the microbial opsin genes and the structure‐function properties of their corresponding proteins.
PSS/E Based Power System Stabilizer Tuning Tool (2020)

Since their introduction, Power System Stabilizers have become widely accepted as an efficient supplementary excitation controller for extending the power transfer capability limits of the system by adding damping to the low-frequency electromechanical modes of oscillation to improve the overall system stability. The purpose of the tool presented in this paper is to enable an easy to use, flexible and accurate tuning of various types of Power System Stabilizers, both for a SMIB, as well as multi-machine system configurations. The tool is built in Python and relies on the dynamic models of the PSS/E library, and the PSS/E steady-state and dynamic simulation modules. The key component of this new tool is PSS/E's linearization module, which generates the linear state-space model around a steady-state operating point of the full non-linear dynamic model of the system. It provides valuable tools necessary for the analysis of the stability phenomena and tackling with the optimization of the stabilizer parameters and validation of the results. The core features of the tool were demonstrated with the well-established Kundur's four-machine test system. Utilizing interpreted language, such as Python, makes it very convenient for potential users to flexibly create custom scripts to perform the analysis and optimization according to their needs and preferences.
Building Energy Management Technology Considering Usual Power Consumption Pattern and Prediction Uncertainty (2020)

This paper proposes a building energy management model in the Korean electric tariff system with the consideration of prediction errors in load consumption and renewable energy generation. The increase in controllable power resources has enabled demand-side managements in the practical environment, and various approaches to optimize power consumption in the building are studied and implemented. However, demand side management has a problem in that it is difficult for power consumers to control power consumption due to the lack of consideration of actual use environment. To resolve this issue, we propose penalty factor to minimize the gap between power scheduling results and usual power usage patterns. In addition, the prediction error of power consumption in real environment causes difficulty in power operation. To resolve the issue, this paper proposes a method to control power demand resources and energy storage system based on a set of reserve portion. The proposed model includes analysis on prediction errors of power data, and set of proper reserve proportion in demand response and energy storage system operation. The simulation results show that the electricity rate of consumers in the building is reduced by more than 21% per month.
Pharmacokinetics of daclizumab high-yield process with repeated administration of the clinical subcutaneous regimen in patients with relapsing-remitting multiple sclerosis (2016)

The PK of DAC HYP in patients with RRMS are consistent with those previously reported in healthy volunteers. The half-life of ~3 weeks and the low fluctuations in peak and trough concentrations of serum DAC HYP support the once-monthly SC dosing regimen.
Poster (2015)

Precise positioning of an automobile to within lane-level precision can enable better navigation and context-awareness. However, GPS by itself cannot provide such precision in obstructed urban environments. In this paper, we present a system called CARLOC for lane-level positioning of automobiles. CARLOC uses three key ideas in concert to improve positioning accuracy: it uses digital maps to match the vehicle to known road segments; it uses vehicular sensors to obtain odometry and bearing information; and it uses crowd-sourced location of estimates of roadway landmarks that can be detected by sensors available in modern vehicles. CARLOC unifies these ideas in a probabilistic position estimation framework, widely used in robotics, called the sequential Monte Carlo method. Through extensive experiments on a real vehicle, we show that CARLOC achieves sub-meter positioning accuracy in an obstructed urban setting, an order-of-magnitude improvement over a high-end GPS device.
Compressed Sensing for Wireless Communications: Useful Tips and Tricks (2017)

As a paradigm to recover the sparse signal from a small set of linear measurements, compressed sensing (CS) has stimulated a great deal of interest in recent years. In order to apply the CS techniques to wireless communication systems, there are a number of things to know and also several issues to be considered. However, it is not easy to grasp simple and easy answers to the issues raised while carrying out research on CS. The main purpose of this paper is to provide essential knowledge and useful tips and tricks that wireless communication researchers need to know when designing CS-based wireless systems. First, we present an overview of the CS technique, including basic setup, sparse recovery algorithm, and performance guarantee. Then, we describe three distinct sub-problems of CS, viz., sparse estimation, support identification, and sparse detection, with various wireless communication applications. We also address main issues encountered in the design of CS-based wireless communication systems. These include potentials and limitations of CS techniques, useful tips that one should be aware of, subtle points that one should pay attention to, and some prior knowledge to achieve better performance. Our hope is that this paper will be a useful guide for wireless communication researchers and even non-experts to get the gist of CS techniques.
A 25 Gb/s Burst-Mode Receiver for Low Latency Photonic Switch Networks (2015)

A DC-coupled burst-mode receiver performs optical power calibration in 12.5ns, achieves phase lock in 18.5ns and tracks input data using a CDR. The sensitivity of the 4.4pJ/bit receiver is −10.9dBm (BER &lt; 10−12) at 25Gb/s.
Ultrahigh Mobility in Solution‐Processed Solid‐State Electrolyte‐Gated Transistors (2017)

A new concept of a high-capacitance polymeric dielectric based on high-k polymer and ion gel blends is reported. This solid-state electrolyte gate insulator enables remarkable field-effect mobilities exceeding 10 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> for common polymer and other semiconductor families at V<sub>G</sub> ≤ 2 V owing to high areal capacitance (>4 µF cm<sup>-2</sup> ) from combined polarization of CF interface dipoles and electrical-double-layer formation.
Characterization of Addressability by Simultaneous Randomized Benchmarking (2012)

The control and handling of errors arising from cross talk and unwanted interactions in multiqubit systems is an important issue in quantum information processing architectures. We introduce a benchmarking protocol that provides information about the amount of addressability present in the system and implement it on coupled superconducting qubits. The protocol consists of randomized benchmarking experiments run both individually and simultaneously on pairs of qubits. A relevant figure of merit for the addressability is then related to the differences in the measured average gate fidelities in the two experiments. We present results from two similar samples with differing cross talk and unwanted qubit-qubit interactions. The results agree with predictions based on simple models of the classical cross talk and Stark shifts.
Improved Functionality of Lithium‐Ion Batteries Enabled by Atomic Layer Deposition on the Porous Microstructure of Polymer Separators and Coating Electrodes (2012)

Abstract Atomic layer deposition (ALD) of Al 2 O 3 is applied on a polypropylene separator for lithium‐ion batteries. A thin Al 2 O 3 layer (&lt;10 nm) is coated on every surface of the porous polymer microframework without significantly increasing the total separator thickness. The thin Al 2 O 3 ALD coating results in significantly suppressed thermal shrinkage, which may lead to improved safety of the batteries. More importantly, the wettability of Al 2 O 3 ALD‐coated separators in an extremely polar electrolyte based on pure propylene carbonate (PC) solvent is demonstrated, without any decrease in electrochemical performances such as capacity, rate capability, and cycle life. Finally, a LiCoO 2 /natural graphite full cell is demonstrated under extremely severe conditions (pure PC‐based electrolyte and high (4.5 V) upper cut‐off potential), which is enabled by the Al 2 O 3 ALD coating on all three components (cathode, anode, and separator).
Modeling and optimization of solar cells (2012)

A methodology is presented for modeling textured wafers, junction engineering for POCl3 and ion-implanted junctions, and electrical performance of the novel solar cell architectures with 3D current crowding. The important design and process trade-offs are demonstrated that enable to make cost-efficient choices to maximize the overall solar cell performance and cost per Watt. The 3D diffusion model is used for the junction formation on textured surfaces, and 3D carrier transport with recombination and traps is used for the electrical analysis.
Distributed average consensus: Beyond the realm of linearity (2009)

In this paper, we present a distributed average-consensus algorithm with non-linear updates. In particular, we use a weighted combination of the sine of the state differences among the nodes as a consensus update instead of the conventional linear update that just includes a weighted combination of the state differences. We show the non-linear average-consensus converges to the initial average under appropriate conditions on the weights. By simulations, we show that the convergence rate of our algorithm outperforms the conventional linear case.
ACTION STIMULANTE DES MICROCOQUES CASÉOLYTIQUES SUR LES BACTÉRIES LACTIQUES THERMOPHILES. MISE EN ÉVIDENCE DE LA NATURE PEPTIDIQUE DES SUBSTANCES STIMULANTES (1970)

Parmi 30 6 souches de microcoques isoles partir d'chantillons de lait prlevs strilement la mamelle, de lait de fromagerie, de lactosrum de fromagerie et de fromages diffrents stades de la fabrication, 45 ont une action stimulante vis--vis des streptocoques thermophiles en culture dans le lait.
BASS: Boolean Automorphisms Signature Scheme (2023)

We offer a digital signature scheme using Boolean automorphisms of a multivariate polynomial algebra over integers. Verification part of this scheme is based on the approximation of the number of zeros of a multivariate Boolean function.
Role of 3′,5′ -Adenosine Monophosphate in Regulation of Morphology and Growth of Transformed and Normal Fibroblasts (1972)

N6,O2′-dibutyryl 3′,5′-adenosine monophosphate (dbc-AMP) altered morphology and growth properties of fibroblasts. During treatment with dbc-AMP, the cell body and processes were elongated, and the cells spread out and occupied a greater area in contact with the substratum. In one cell line, which normally showed extensive vacuolization, dbc-AMP greatly decreased the vacuole content. Morphologic changes were observed with all cell lines tested, including Swiss/3T3, BALB/3T3, and Swiss/3T3 and BALB/3T3 cells transformed by polyoma virus, murine leukemia and sarcoma viruses, and simian virus 40 (SV40). Usually, the changes in the SV40-transformed cells were not as extensive as those observed with the others. Also, L-2071 cells, a line that grows on a chemically defined, protein-free medium, and BHK-21 cells were responsive. Dibutyryl cyclic AMP decreased the growth rate of the cells; the effect was potentiated by theophylline. The treatment decreased by seven-fold the saturation density of 3T3 cells, a line normally displaying contact inhibition of growth at a relatively low cell density. But dbc-AMP even with theophylline did not markedly decrease the saturation density of the non-contact-inhibited transformed cells.