gebhart/patrepeval huggingface dataset:
The Influence of Differential Privacy on Short Term Electric Load Forecasting (2018)

There has been a large number of contributions on privacy-preserving smart metering with Differential Privacy, addressing questions from actual enforcement at the smart meter to billing at the energy provider. However, exploitation is mostly limited to application of cryptographic security means between smart meters and energy providers. We illustrate along the use case of privacy preserving load forecasting that Differential Privacy is indeed a valuable addition that unlocks novel information flows for optimization. We show that (i) there are large differences in utility along three selected forecasting methods, (ii) energy providers can enjoy good utility especially under the linear regression benchmark model, and (iii) households can participate in privacy preserving load forecasting with an individual membership inference risk &lt;60%, only 10% over random guessing.
Supplementary References from MicroRNA Microarray Identifies <i>Let-7i</i> as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer (2023)

Supplementary References from MicroRNA Microarray Identifies &lt;i&gt;Let-7i&lt;/i&gt; as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer
The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360. (1991)

Apolipoprotein (apo) A-IV is a protein involved in the metabolism of chylomicrons and high density lipoproteins. This protein displays genetic polymorphism due to two main codominant alleles, A-IV1 and A-IV2. We have identified the mutation that leads to this polymorphism. It is caused by a single-base substitution of guanine for thymine in the third base of codon 360. This substitution leads to a glutamine to histidine change. Direct sequencing of amplified DNA from eight subjects in a three-generation pedigree has demonstrated that the guanine to thymine substitution can explain the apo A-IV polymorphism. In 32 unrelated individuals, a correspondence between apo A-IV phenotype determined by isoelectric focusing and genotype determined with Fnu4HI digestion of amplified DNA could be demonstrated. The enzyme lecithin:cholesteryl acyltransferase (LCAT) is activated by apo A-IV. Under our in vitro conditions, the isoprotein apo A-IV 1-1 is a better LCAT activator than is the isoprotein apo A-IV 2-2. A knowledge of the molecular mechanism underlying the apo A-IV polymorphism will help to elucidate the mechanisms involved in LCAT activation.
Comparative ultrastructural studies of nucleoli of tumor cells treated with adriamycin and the newer anthracyclines, carminomycin and marcellomycin. (1978)

This study was designed to determine the effects of several antitimor anthracyclines, including Adriamycin and its analogs, carminomycin and marcellomycin, on the ultrastructure of nucleoli of Novikoff hepatoma cells. Adriamycin and carminomycin, which are structurally related, induce nucleolar segregation following the formation of conspicuous fibrillar centers. Marcellomycin did not induce formation of nucleolar fibrillar centers. Instead, numerous microspherules formed following treatment with marcellomycin; later complete nucleolar segregation developed. The microspherules were observed to be in various stages of extrusion from the nucleolar body. This microspherule "migration" appeared to be both time and drug concentration dependent. These results show that the rate and extent of nucleolar ultrastructural aberration may be related to structural differences of the various anthracyclines.
Dititanium‐Containing 19‐Tungstodiarsenate(III) [Ti2(OH)2As2W19O67(H2O)]8−: Synthesis, Structure, Electrochemistry, and Oxidation Catalysis (2007)

The dititanium-containing 19-tungstodiarsenate(III) [Ti(2)(OH)(2)As(2)W(19)O(67)(H(2)O)](8-) (1) has been synthesized and characterized by IR, TGA, elemental analysis, electrochemistry, and catalytic studies. Single-crystal X-ray analysis was carried out on Cs(8)[Ti(2)(OH)(2)As(2)W(19)O(67)(H(2)O)].2CsCl.12H(2)O (Cs-1), which crystallizes in the monoclinic system, space group P2(1)/m, with a=12.7764(19), b=19.425(3), c=18.149(3) A, beta=110.234(3) degrees, and Z=2. Polyanion 1 comprises two (B-alpha-As(III)W(9)O(33)) Keggin moieties linked through an octahedral {WO(5)(H(2)O)} fragment and two unprecedented square-pyramidal {TiO(4)(OH)} groups, leading to a sandwich-type structure with nominal C(2v) symmetry. Synthesis of 1 was accomplished by reaction of TiOSO(4) and K(14)[As(2)W(19)O(67)(H(2)O)] in a 2:1 molar ratio in aqueous, acidic medium (pH 2). Polyanion 1 could also be isolated as a tetra-n-butyl ammonium (TBA) salt, {(n-C(4)H(9))(4)N}(5)H(3)[Ti(2)(OH)(2)As(2)W(19)O(67)(H(2)O)] (TBA-1). TBA-1 was studied by cyclic voltammetry in acetonitrile (MeCN) solutions containing 0.1 M LiClO(4) and compared with the results obtained with Cs-1 in aqueous media. In MeCN, the Ti(IV) and W(VI) waves could not be separated distinctly. An important adsorption phenomenon on the glassy carbon working electrode was encountered both in cyclic voltammetry and in controlled potential electrolysis and was confirmed by Electrochemical Quartz Crystal Microbalance (EQCM) studies on a carbon film. TBA-1, dissolved in MeCN, reacts with H(2)O(2) to give peroxo complexes stable enough for characterization by UV-visible spectroscopy, cyclic voltammetry, and EQCM. TBA-1 shows high catalytic activity (TOF=11.3 h(-1)) in cyclohexene oxidation with aqueous H(2)O(2) producing products typical of a heterolytic oxidation mechanism. The stability of TBA-1 under turnover conditions was confirmed by using IR, UV-visible spectroscopy as well as cyclic voltammetry.
Smooth oxidation of phosphorus closo-type compounds. Preparation and characterization of the closo-hexa-N-methyloxythiophosphorimides P4(NMe)6SnO4-n (n = 0-3) and an improved synthesis for the closo-hexa-N-methylthiophosphorimides (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSmooth oxidation of phosphorus closo-type compounds. Preparation and characterization of the closo-hexa-N-methyloxythiophosphorimides P4(NMe)6SnO4-n (n = 0-3) and an improved synthesis for the closo-hexa-N-methylthiophosphorimidesFrancis. Casabianca, A. Alan. Pinkerton, and Jean G. RiessCite this: Inorg. Chem. 1977, 16, 4, 864–867Publication Date (Print):April 1, 1977Publication History Published online1 May 2002Published inissue 1 April 1977https://pubs.acs.org/doi/10.1021/ic50170a028https://doi.org/10.1021/ic50170a028research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis of Hydroxy-Functional PMMA Macromonomers by Anionic Polymerization (2009)

Living anionic polymerization has been utilized to synthesize hydroxy end-functionalized PMMA macromonomers with styryl or allyl functionalities as the polymerizable end-groups. Protected hydroxy-functionalized alkyl lithium initiators have been used to initiate anionic polymerization of MMA. Subsequently the living chains with protected hydroxyl function have been terminated using 4-vinylbenzyl chloride (4-VBC) or allyl methacrylate (ALMA) to form α-hydroxy-ω-styryl and α-hydroxy-ω-allyl PMMA, respectively. These protected hydroxy-functionalized PMMA macromonomers have been characterized by GPC and 1H-NMR. Termination using 4-VBC led to 50% functionalization, whereas that using allyl methacrylate led to 100% functionalization of the hydroxy-PMMA.
Electronic structure of the (1×1) oxygen overlayer on TiC(111): Angle-resolved photoemission study (1992)

Angle-resolved photoemission spectroscopy with synchrotron radiation has been used to study the electronic state of oxygen adsorbed on a TiC(111) surface at room temperature. Oxygen is adsorbed dissociatively forming a (1\ifmmode\times\else\texttimes\fi{}1) overlayer on the TiC(111) surface at saturation coverage. The band structure of the (1\ifmmode\times\else\texttimes\fi{}1)-O overlayer is measured in the two symmetry directions; 〈21\ifmmode\bar\else\textasciimacron\fi{} 1\ifmmode\bar\else\textasciimacron\fi{}〉(\ensuremath{\Gamma}\ifmmode\bar\else\textasciimacron\fi{} M\ifmmode\bar\else\textasciimacron\fi{}) and 〈011\ifmmode\bar\else\textasciimacron\fi{}〉(\ensuremath{\Gamma}\ifmmode\bar\else\textasciimacron\fi{} K\ifmmode\bar\else\textasciimacron\fi{}) of the TiC(111) surface. The binding energy of the O 2${\mathit{p}}_{\mathit{z}}$-derived band is always lower than those of the O 2${\mathit{p}}_{\mathit{x}}$- and O 2${\mathit{p}}_{\mathit{y}}$-derived bands throughout the surface Brillouin zone, indicating that the 2${\mathit{p}}_{\mathit{x}}$ and 2${\mathit{p}}_{\mathit{y}}$ orbitals are more important for the chemisorption bond formation.
Mechanism of metal catalysts controlling formation of single-wall carbon nanotubes (2000)

In the formation of single-wall carbon nanotubes (SWNTs) by laser ablation and arc discharge, metal catalysts are necessary. We found that NiCo was the most effective in catalyzing SWNT formation and that other metals followed the order NiCo>Ni∼NiFe≫Co∼Fe. We confirmed that all these metals were effective catalysts of graphitization, indicating their equal potential-ability for catalyzing SWNT formation. The reason Co and Fe could not well catalyze SWNT formation in laser ablation and arc discharge is discussed based on the segregation manner of graphite on Co and Fe.
Chromosome-level de novo assembly of the pig-tailed macaque genome using linked-read sequencing and HiC proximity scaffolding (2020)

These findings demonstrate that pig-tailed macaques can serve as an excellent animal model for the study of many human diseases particularly with regards to pluripotency and innate immune pathways.
Kerr-Lens Mode-Locked Femtosecond mid-IR Laser Oscillations in Polycrystalline Cr^2+:ZnSe and Cr^2+:ZnS (2014)

We demonstrate Kerr-lens mode-locked polycrystalline Cr2+:ZnSe and Cr2+:ZnS lasers with pulse duration of 125 fs, 160 MHz pulse repetition rate and output power of 60 mW (Cr2+:ZnSe) and 30 mW (Cr2+:ZnS).
Cardiac Tissue Engineering: “Reconstructing the Motor of Life” (2007)

Cardiovascular diseases are the number one cause of death globally (1). But at the time, for a majority of the acquired or congenital diseases a sufficient form of therapy is missing and oftentimes a cardiac substitute is needed to overcome cardiovascular diseases. However, donor organs are rare and common prostheses have several disadvantages. As an alternative solution to resolve these problems, tissue engineering is under discussion as it promises to re-engineer human tissues and organs. A definition of tissue engineering was given by Biomedical Engineering Handbook (2): The application of scientific principles to the design, construction, modification, growth and maintenance of living Tissue engineering includes three main topics for the generation of artificial living tissue: 1) Biomaterials to create matrices, which give 3-dimensional design and mechanical properties to the construct. 2) Cell culture and molecular biology to provide cells specific for the counterpart of native tissue. 3) Biotechnology and bioengineering principles are needed to create bioreactor assemblies that provide in vitro conditions similar to those in vivo; including adjustment of pH, temperature, nutrient and oxygen supply, and if needed a set-up for physical stress stimuli like shear stress, mechanical tension or electrical stimulation. With recent improvements in these fields, tissue engineering now is very promising for the future treatment of several diseases. Specially to overcome cardiovascular diseases, the research to generate substitutes for heart valves, the heart muscle and for vessels is pushed forward.
Development of Rotation Dark-Field Imaging for Mapping Secondary-Phase Distributions in Nano-Scale (2011)

Extended abstract of a paper presented at Microscopy and Microanalysis 2011 in Nashville, Tennessee, USA, August 7–August 11, 2011.
Performance spectra based method for the seismic design of structures equipped with passive supplemental damping systems (2012)

SUMMARY A new direct performance‐based design method utilizing design tools called performance‐spectra (P‐Spectra) for low‐rise to medium‐rise frame structures incorporating supplemental damping devices is presented. P‐Spectra are graphic tools that relate the responses of nonlinear SDOF systems with supplemental dampers to various damping parameters and dynamic system properties that structural designers can control. These tools integrate multiple response quantities that are important to the performance of a structure into a single compact graphical format to facilitate direct comparison of different potential solutions that satisfy a set of predetermined performance objectives under various levels of seismic hazard. An SDOF to MDOF transformation procedure that defines the required supplemental damping properties for the MDOF structure to achieve the response defined by the target SDOF system is also presented for hysteretic, linear viscous and viscoelastic damping devices. Using nonlinear time‐history analyses of idealized shear structures, the accuracy of the transformation procedure is verified. A seismic performance upgrade design example is presented to demonstrate the usefulness of the proposed method for achieving design performance goals using supplemental damping devices. Copyright © 2012 John Wiley &amp; Sons, Ltd.
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry (2020)

Optimization of small-molecule probes or drugs is a synthetically lengthy, challenging, and resource-intensive process. Lack of automation and reliance on skilled medicinal chemists is cumbersome in both academic and industrial settings. Here, we demonstrate a high-throughput hit-to-lead process based on the biocompatible sulfur(VI) fluoride exchange (SuFEx) click chemistry. A high-throughput screening hit benzyl (cyanomethyl)carbamate (<i>K</i><sub>i</sub> = 8 μM) against a bacterial cysteine protease SpeB was modified with a SuFExable iminosulfur oxydifluoride [RN═S(O)F<sub>2</sub>] motif, rapidly diversified into 460 analogs in overnight reactions, and the products were directly screened to yield drug-like inhibitors with 480-fold higher potency (<i>K</i><sub>i</sub> = 18 nM). We showed that the improved molecule is active in a bacteria-host coculture. Since this SuFEx linkage reaction succeeds on picomole scale for direct screening, we anticipate our methodology can accelerate the development of robust biological probes and drug candidates.
Insulin binds to and promotes the phosphorylation of a Mr 210 000 component of its receptor in detergent extracts of rat liver microsomes (1983)

Insulin in the presence of Mn2+ and [gamma 32P]ATP promoted the phosphorylation of two proteins of Mr 95 000 and Mr 210 000 in detergent extracts of rat liver microsomes. The Mr 210 000 protein was identified as a component od the insulin receptor by immunoprecipitation. It also bound [125I]insulin specifically, was phosphorylated largely on a tyrosine residue and could not be cleaved to smaller subunits under extreme reducing conditions. The Mr 210 000 protein appears to be a component of a sub-population of liver membrane insulin receptors in which insulin-binding and insulin-stimulated tyrosine kinase phosphorylation site(s) reside in a single polypeptide chain.
Neoadjuvant Hormonal Deprivation in Patients with Locally Advanced Prostate Cancer (1993)

A total of 22 patients with locally advanced prostate cancer (stage B2 to C) was entered into a protocol for 3 months of preoperative hormonal deprivation. Of the patients 8 were judged to have clinical stage B2 and 14 to have stage C disease. The protocol regimen consisted of daily administration of flutamide (250 mg. orally 3 times per day) and leuprolide injection (7.5 mg. intramuscularly) every month. Patients with objective evidence of downstaging by prostate specific antigen (PSA) levels and transrectal ultrasound were offered surgical therapy. Of the 22 patients 20 have completed the protocol and are evaluable, and 2 of them did not show significant downstaging and elected radiotherapy. Preoperative hormonal therapy produced an average 33% downsizing of the prostate gland as determined by transrectal ultrasound volumetrics. Decreases in serum PSA values were demonstrated from a pre-hormonal average of 30 micrograms./l. (range 0.7 to 97.7) to an average of 0.53 micrograms./l. (range 0.2 to 5.7) after hormonal therapy. Of the 18 patients who underwent an operation after demonstrating significant downsizing 7 had pathologically confirmed stage B disease, 7 had stage C cancer and 4 had positive pelvic lymph nodes. Of the 8 clinical stage B2 cancer patients 3 had pathological stage B2 disease following the protocol. Of the 12 clinical stage C cancer patients 3 had pathological stage B disease, 4 had positive pelvic lymph nodes and the remainder had pathological stage C cancer. Thus, only 3 of 20 patients (15%) demonstrated pathological downstaging from the clinical stage. Downsizing the prostate volume and PSA changes with hormonal therapy were not predictive of patient outcome either alone or in combination. Preoperative hormonal therapy did not appear to facilitate the surgical procedure. Patients completing neoadjuvant hormonal therapy had an average estimated blood loss of 1,238 ml. and an average operating time of 183 minutes. A group of 20 consecutive patients with stage B2 prostate cancer who underwent radical prostatectomy without preoperative hormone therapy had an average estimated blood loss of 1,296 ml. and an average operating time of 171 minutes.
Soft-switching-interleaved power factor correction converter with lossless snubber (2013)

This paper describes a soft-switching-interleaved power factor correction (PFC) converter. The proposed PFC converter reduces the input-current ripple by using an interleave-control method and realizes high efficiency through the soft-switching operation of all switching devices, without requiring a large auxiliary resonant circuit. In order to confirm that the proposed converter achieves soft-switching operation, a prototype of the PFC converter was experimentally investigated. The experimental results indicate that the proposed converter can realize soft-switching operation on all switching devices, reduce the amount of input current ripple, generate a unity input power factor of 99% or more, and maintain both a sinusoidal input current and a constant output-voltage control. The efficiency of the proposed PFC converter with a lossless snubber is higher than that of the PFC converter without the snubber. Moreover, an improvement technique for reducing the power-source current distortion is proposed. Improvement in the amount of source-current distortion is confirmed by using a waveform-improvement method in both the simulation and the experiment, reducing the total harmonic distortion (THD) by 2.74%.
Variation of the Viologen Electron Relay in Cyclodextrin‐Based Self‐Assembled Systems for Photoinduced Hydrogen Evolution from Water (2012)

Abstract The light‐driven reduction of protons for the production of molecular hydrogen in multicomponent systems depends on electron relays such as viologens. We describe here the effect of viologens appended with guest moieties (adamantane or bile acid) on the efficiency of a system composed of a cyclodextrin‐appended photosensitizer [Ir(ppy) 2 (pytl‐βCD)]Cl [ppy = 2‐phenylpyridine; pytl = 2‐(1‐substituted‐1 H ‐1,2,3‐triazol‐4‐yl)pyridine; CD = cyclodextrin], cyclodextrin‐modified Pt nanoparticles as the catalyst, and ethylenediaminetetraacetic acid (EDTA) as the sacrificial donor. The system was designed to self‐assemble in a supramolecular manner in order to promote electron transfer and produce hydrogen. Cyclic voltammetry (CV) measurements in DMF showed that the electron‐donating adamantyl substituent decreases the reduction potential of the viologen. The use of symmetric and asymmetric guest‐appended viologens gave rise to unexpected phenomena in the H 2 evolution. The presence of adamantane or bile acid groups on the viologen induced stabilization and aggregation of the radical cations in water, which is disadvantageous for hydrogen formation.
Development of compact and scalable packaging for fiber-coupled single-photon detector array (2016)

We present our progress in creating compact and scalable packaging to couple a 32 element fiber array to a corresponding array of single photon detectors for test at cryogenic temperatures. The packaging was thermally cycled down to 4.2 K to demonstrate stability.
Chiral Strandberg‐Type Molybdates [(RPO3)2Mo5O15]2− as Molecular Gelators: Self‐Assembled Fibrillar Nanostructures with Enhanced Optical Activity (2008)

Twisted fibers with a helical structure are formed by self-assembly of chiral polyoxomolybdates (POMs) [(R*PO3)2Mo5O15]2− (R=CH3CH(NH3), CH3CH(CH3)CH(NH3)) through H-bonding. High-resolution TEM images of single fibers show an ordered substructure with parallel rows about 2 nm in width, in agreement with the packing of the H-bonded POM subunits in the X-ray structure
Letters (2002)

Gonzalez, L. Fernando MD; Sonntag, Volker K. H. MD; Dickman, Curtis A. MD; Crawford, Neil R. PhD Author Information