gebhart/patrepeval huggingface dataset:
Characterizing and Predicting Voice Query Reformulation (2015)

Voice interactions are becoming more prevalent as the usage of voice search and intelligent assistants gains more popularity. Users frequently reformulate their requests in hope of getting better results either because the system was unable to recognize what they said or because it was able to recognize it but was unable to return the desired response. Query reformulation has been extensively studied in the context of text input. Many of the characteristics studied in the context of text query reformulation are potentially useful for voice query reformulation. However, voice query reformulation has its unique characteristics in terms of the reasons that lead users to reformulating their queries and how they reformulate them. In this paper, we study the problem of voice query reformulation. We perform a large scale human annotation study to collect thousands of labeled instances of voice reformulation and non-reformulation query pairs. We use this data to compare and contrast characteristics of reformulation and non-reformulation queries over a large a number of dimensions. We then train classifiers to distinguish between reformulation and non-reformulation query pairs and to predict the rationale behind reformulation. We demonstrate through experiments with the human labeled data that our classifiers achieve good performance in both tasks.
A geometric model of a V-slit Sun sensor correcting for spacecraft wobble (1994)

A V-Slit sun sensor is body-mounted on a spin-stabilized spacecraft. During injection from a parking or transfer orbit to some final orbit, the spacecraft may not be dynamically balanced. This may result in wobble about the spacecraft spin axis as the spin axis may not be aligned with the spacecraft's axis of symmetry. While the widely used models in Spacecraft Attitude Determination and Control, edited by Wertz, correct for separation, elevation, and azimuthal mounting biases, spacecraft wobble is not taken into consideration. A geometric approach is used to develop a method for measurement of the sun angle which corrects for the magnitude and phase of spacecraft wobble. The algorithm was implemented using a set of standard mathematical routines for spherical geometry on a unit sphere.
The first ALS2 missense mutation associated with JPLS reveals new aspects of alsin biological function (2006)

Primary lateral sclerosis (PLS) is a rare progressive paralytic disorder that results from dysfunction of the upper motoneurons. Although PLS is a sporadic disorder of adult middle age, it has also been described in children as juvenile PLS or JPLS. The causative gene for JPLS was found to be ALS2, which is also responsible for a recessive form of amyotrophic lateral sclerosis, for infantile onset ascending hereditary spastic paralysis (IAHSP) and for a form of complicated hereditary spastic paraplegia (cHSP). ALS2 gene encodes a protein termed alsin, containing multiple guanine nucleotide exchange factor domains, specifically binding to small GTPase Rab5 and acting as a GEF for Rab5. In vitrostudies performed with full-length and truncating forms of alsin protein support its role in endosomal dynamics and trafficking of mitochondria. All ALS2 mutations so far reported generate alsin protein truncation. Here, we describe the first homozygous missense mutation in ALS2, p.G540E. The mutation, which falls within the RCC1 domain, was identified in a 34-year-old patient with typical signs of JPLS such as ascending generalized and severe spasticity involving the limbs and the bulbar region, dysphagia, limb atrophy, preserved cognition and sensation. The father and two proband's sisters were found to be heterozygous carriers of the mutation with no signs of the disease. Studies in the neuronal cell line SK-N-BE indicated that the known subcellular localization of wild-type alsin with the early endosome antigen 1, in enlarged endosomal structures, and transferrin receptor is completely lost by the mutant protein, thus indicating that this mutation leads to protein delocalization. Mutant alsin induced neuronal death itself and also significantly enhanced the apoptogenic effect of NMDA and staurosporine. This effect was associated with decreased Bcl-xL : Bax ratio. In contrast, wild-type alsin was neuroprotective and increased Bcl-xL : Bax ratio. Our results provide the first demonstration that a missense mutation in alsin is cytotoxic. In addition, the identification of Bcl-xL/Bax as target of protection by alsin and of cytotoxicity by the mutant form provides a new signalling event regulated by alsin protein that may be important to define its role in neuronal physiology and neurodegeneration. Finally, the phenotype-genotype correlation in our patient, in view of all other ALS2 mutant cases reported previously, suggests a functional interplay of long and short forms of alsin in relation to disease onset and progression.
Ig VH gene expression among human follicular lymphomas (1991)

Thirty-six randomly selected cases of low grade follicular lymphoma (FL) were analyzed for Ig heavy chain variable region (VH) gene expression. Assignment to one of the six human VH gene families (VH1 to VH6) was made with a polymerase chain reaction-based technique using family-specific leader primers. The frequency of VH family use in FL was found to be similar to that reported for normal peripheral blood lymphocytes and is therefore also roughly proportional to VH family size. To evaluate expression within an individual family, all of the lymphoma VH genes from the middle size VH4 family were sequenced and compared with previously published sequences. Of these eight lymphoma VH sequences, six were most closely related to just two of the 10 known functional VH4 germline genes. Nonrandom usage by FL of the JH3, JH4, and JH5 joining segments was also observed. Nucleotide sequences were also determined for 10 randomly selected lymphoma VH genes from the large VH3 family. With one possible exception, none of these lymphoma VH sequences appear to represent any of the VH3 genes that may be preferentially used in the fetal repertoire.
P‐44: Overall Judgment by Comparison with Polish and Matt Surface for some FPDs with Analytic Hierarchy Process (2008)

Abstract We evaluated the priority order among four image quality factors:legibility/readability, sharpness/pureness, graleness/fatigue and reality/fidelity, and compared the image qualities to four surface treatments: polish, polish with anti‐reflection treatment and matt surfaces as 12% and 25% haze, for three applications with main size panels: mobile‐phone, PC, television by using analytic hierarchy process.
Modified lithium vanadium oxide electrode materials products and methods (2023)

A method of improving certain vanadium oxide formulations is presented. The method concerns fluorine doping formulations having a nominal formula of LiV.sub.3 O.sub.8. Preferred average formulations are provided wherein the average oxidation state of the vanadium is at least 4.6. Herein preferred fluorine doped vanadium oxide materials, electrodes using such materials, and batteries including at least one electrode therein comprising such materials are provided.
Comparison of Questionnaire and Performance‐Based Physical Frailty Scales to Predict Survival and Health‐Related Quality of Life in Patients With Heart Failure (2023)

Background Frailty is prevalent in older adults with heart failure and is associated with poor outcomes; however, there remains uncertainty on how to measure frailty in clinical practice. Methods and Results A multicentric prospective cohort study was assembled at 4 heart failure clinics to compare the prognostic value of 3 physical frailty scales in ambulatory patients with heart failure. Outcomes were all-cause death or hospitalization and health-related quality of life using the 36-Item Short Form survey questionnaire (SF-36) at 3 months. Multivariable regression was adjusted for age, sex, Meta-Analysis Global Group in Chronic Heart Failure score, and baseline SF-36 score. The cohort included 215 patients (mean age 77.6 years). All 3 frailty scales were independently associated with death or hospitalization at 3 months; the adjusted odds ratios standardized per 1 SD worsening of the Short Physical Performance Battery; Fried, and strength, assistance with walking, rising from a chair, climbing stairs, and falls scales were 1.67 (95% CI, 1.09-2.55), 1.60 (95% CI, 1.04-2.46), and 1.55 (95% CI, 1.03-2.35), respectively, with C statistics of 0.77 to 0.78. All 3 frailty scales were independently associated with worsening SF-36 scores, especially the Short Physical Performance Battery, for which 1 SD worsening of frailty translated to a decrement of -5.86 (-8.55 to -3.17) and -5.51 (-7.82 to -3.21) points in the Physical Component Score and Mental Component Score. Conclusions All 3 physical frailty scales were associated with death, hospitalization, and reduced health-related quality of life in ambulatory patients with heart failure. Questionnaire or performance-based physical frailty scales can be used to offer prognostic value and a therapeutic target in this vulnerable population. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT03887351.
Safety of phosphatidylserine containing omega3 fatty acids in ADHD children: A double-blind placebo-controlled trial followed by an open-label extension (2013)

Study results demonstrate that consumption of PS-Omega3 by children with ADHD, as indicated in a 30-week evaluation period, is safe and well tolerated, without any negative effect on body weight or growth.
Structural and Pharmacological Differences between Codfish and Rat Brain α1‐Adrenergic Receptors Revealed by Photoaffinity Labeling with125I‐APDQ (1986)

The photoaffinity probe 125I-APDQ has been used to characterize alpha 1-receptor peptides in the cod and rat brains. In the cod brain a major specific peptide of Mr = 68,000 could be covalently labeled by 125I-APDQ as revealed by SDS-PAGE. In the rat brain a specific peptide with Mr = 77,000 was instead labeled. When a number of adrenergic agonists and antagonists were tested for their ability to protect the labeling by 125I-APDQ their potencies were those expected for alpha 1-receptors in both species. The ligand binding peptide in the cod brain also distinguished between stereoisomers of epinephrine as expected for a physiological receptor. However, there was a distinct difference between the cod and rat alpha 1-receptor in that the beta-agonist 1-isoprenaline was equipotent to 1-norepinephrine in the cod whereas it was less potent in the rat. The protecting ability of the tested agents were also matched by their ability to displace the alpha 1-adrenergic ligand 3H-prazosin from alpha 1-receptor binding sites in brain membranes from both species. Thus, the codfish alpha 1-receptor seems to be different from mammalian alpha 1-receptors both structurally and pharmacologically.
Structure, bonding, and chemistry of closo-tetraphosphorus hexabis(methylimide), P4(NCH3)6, and its derivatives. 3. Structures of the dithio and trithio derivatives (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure, bonding, and chemistry of closo-tetraphosphorus hexabis(methylimide), P4(NCH3)6, and its derivatives. 3. Structures of the dithio and trithio derivativesF. Albert Cotton, Jean G. Riess, Catherine E. Rice, and B. Ray StultsCite this: Inorg. Chem. 1982, 21, 8, 3123–3126Publication Date (Print):August 1, 1982Publication History Published online1 May 2002Published inissue 1 August 1982https://pubs.acs.org/doi/10.1021/ic00138a040https://doi.org/10.1021/ic00138a040research-articleACS PublicationsRequest reuse permissionsArticle Views63Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel (2020)

GLIC is a bacterial homologue of the pentameric ligand-gated ion channels (pLGICs) that mediate the fast chemical neurotransmission of nerve signalling in eukaryotes. Because the activation and allosteric modulation features are conserved among prokaryotic and eukaryotic pLGICs, GLIC is commonly used as a model to study the allosteric transition and structural pharmacology of pLGICs. It has previously been shown that GLIC is inhibited by some carboxylic acid derivatives. Here, experimental evidence for carboxylate binding to GLIC is provided by solving its X-ray structures with a series of monocarboxylate and dicarboxylate derivatives, and two carboxylate-binding sites are described: (i) the `intersubunit' site that partially overlaps the canonical pLGIC orthosteric site and (ii) the `intrasubunit' vestibular site, which is only occupied by a subset of the described derivatives. While the intersubunit site is widely conserved in all pLGICs, the intrasubunit site is only conserved in cationic eukaryotic pLGICs. This study sheds light on the importance of these two extracellular modulation sites as potential drug targets in pLGICs.
ChemInform Abstract: PREPARATION OF MONOMETHYL‐NIOBIUM(V) AND ‐TANTALUM(V) HALIDES AND OF SOME OF THEIR COMPLEXES (1974)

Abstract Die Titelverbindungen (I) werden durch Behandlung von Nb(V)‐ und Ta(V)‐halogeniden mit Dimethyl‐Hg oder Tetramethylstannan synthetisiert.
MIL-100(Fe) Sub-Micrometric Capsules as a Dual Drug Delivery System (2022)

Nanoparticles of metal-organic frameworks (MOF NPs) are crystalline hybrid micro- or mesoporous nanomaterials that show great promise in biomedicine due to their significant drug loading ability and controlled release. Herein, we develop porous capsules from aggregate of nanoparticles of the iron carboxylate MIL-100(Fe) through a low-temperature spray-drying route. This enables the concomitant one-pot encapsulation of high loading of an antitumor drug, methotrexate, within the pores of the MOF NPs, and the collagenase enzyme (COL), inside the inter-particular mesoporous cavities, upon the formation of the capsule, enhancing tumor treatment. This association provides better control of the release of the active moieties, MTX and collagenase, in simulated body fluid conditions in comparison with the bare MOF NPs. In addition, the loaded MIL-100 capsules present, against the A-375 cancer cell line, selective toxicity nine times higher than for the normal HaCaT cells, suggesting that MTX@COL@MIL-100 capsules may have potential application in the selective treatment of cancer cells. We highlight that an appropriate level of collagenase activity remained after encapsulation using the spray dryer equipment. Therefore, this work describes a novel application of MOF-based capsules as a dual drug delivery system for cancer treatment.
Vibroplasty for Mixed and Conductive Hearing Loss (2013)

Modern application methods of an active middle ear implant (VSB) open new therapeutic options for patients with various outer and middle ear diseases resulting in conductive or mixed hearing loss. Titanium couplers can help to couple the active middle ear implant in a standardized way to remnants of the ossicular chain or to the round window. Thus, the active middle ear implant has been established as an alternative treatment option for patients with mixed and conductive hearing. However, the heterogeneity of the studies published so far complicates the analysis of the audiometric results, and thus, the functional hearing gain after VSB implantation varies a lot.
A fast hierarchical arbitration scheme for multi-tb/s packet switches with shared memory switching (2009)

One challenge in multi-terabit per second packet switches is the design of low latency and high performance arbitration schemes. In this regard, we propose a hierarchical multi-cell arbiter, which interconnects multiple parallel processing devices. By comparison with iterative non-hierarchical multi-cell arbiters, we show that our scheme significantly decreases the signaling overhead and arbitration processing time. Performance evaluation results show the proposed solution maximizes the switch throughput and delay performance.
The Hidden cost of the Edge: A Performance Comparison of Edge and Cloud Latencies (2021)

Edge computing has emerged as a popular paradigm for running latency-sensitive applications due to its ability to offer lower network latencies to end-users. In this paper, we argue that despite its lower network latency, the resource-constrained nature of the edge can result in higher end-to-end latency, especially at higher utilizations, when compared to cloud data centers. We study this edge performance inversion problem through an analytic comparison of edge and cloud latencies and analyze conditions under which the edge can yield worse performance than the cloud. To verify our analytic results, we conduct a detailed experimental comparison of the edge and the cloud latencies using a realistic application and real cloud workloads. Both our analytical and experimental results show that even at moderate utilizations, the edge queuing delays can offset the benefits of lower network latencies, and even result in performance inversion where running in the cloud would provide superior latencies. We finally discuss practical implications of our results and provide insights into how application designers and service providers should design edge applications and systems to avoid these pitfalls.
Heart-Type Fatty Acid Binding Protein Binds Long-Chain Acylcarnitines and Protects against Lipotoxicity (2023)

Heart-type fatty-acid binding protein (FABP3) is an essential cytosolic lipid transport protein found in cardiomyocytes. FABP3 binds fatty acids (FAs) reversibly and with high affinity. Acylcarnitines (ACs) are an esterified form of FAs that play an important role in cellular energy metabolism. However, an increased concentration of ACs can exert detrimental effects on cardiac mitochondria and lead to severe cardiac damage. In the present study, we evaluated the ability of FABP3 to bind long-chain ACs (LCACs) and protect cells from their harmful effects. We characterized the novel binding mechanism between FABP3 and LCACs by a cytotoxicity assay, nuclear magnetic resonance, and isothermal titration calorimetry. Our data demonstrate that FABP3 is capable of binding both FAs and LCACs as well as decreasing the cytotoxicity of LCACs. Our findings reveal that LCACs and FAs compete for the binding site of FABP3. Thus, the protective mechanism of FABP3 is found to be concentration dependent.
ChemInform Abstract: WATER OXIDATION TO OXYGEN BY CERIUM(IV) IONS MEDIATED BY RUTHENIUM DIOXIDE CATALYST (1984)

Abstract Es wird gezeigt, daß Ce(IV)‐Ionen in Gegenwart des Katalysators RuO 2 in 0.5 mol dm ‐3 H 2 SO 4 ‐Lösung H 2 O zu O 2 oxidieren.
Photonic Crystal (PC) Waveguide Based Optical Filters for Dense Integration of High Sensitivity PC Biosensors (2014)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text H. Yan, Y. Zou, C. Yang, Z. Wang, N. Tang, S. Chakravarty, and R. T. Chen, "Photonic Crystal (PC) Waveguide Based Optical Filters for Dense Integration of High Sensitivity PC Biosensors," in CLEO: 2014, OSA Technical Digest (online) (Optica Publishing Group, 2014), paper JTu4A.94. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Detection of low frequency FGFR3 mutations in the urine of bladder cancer patients using next-generation deep sequencing (2012)

Biological fluid-based noninvasive biomarker assays for monitoring and diagnosing disease are clinically powerful. A major technical hurdle for developing these assays is the requirement of high analytical sensitivity so that biomarkers present at very low levels can be consistently detected. In the case of biological fluid-based cancer diagnostic assays, sensitivities similar to those of tissue-based assays are difficult to achieve with DNA markers due to the high abundance of normal DNA background present in the sample. Here we describe a new urine-based assay that uses ultradeep sequencing technology to detect single mutant molecules of fibroblast growth factor receptor 3 (FGFR3) DNA that are indicative of bladder cancer. Detection of FGFR3 mutations in urine would provide clinicians with a noninvasive means of diagnosing early-stage bladder cancer. The single-molecule assay detects FGFR3 mutant DNA when present at as low as 0.02% of total urine DNA and results in 91% concordance with the frequency that FGFR3 mutations are detected in bladder cancer tumors, significantly improving diagnostic performance. To our knowledge, this is the first practical application of next-generation sequencing technology for noninvasive cancer diagnostics.
Bioassay of dgPMCAb-derived PrPres in Syrian hamsters. (2017)

&lt;p&gt;&lt;b&gt;a&lt;/b&gt; Western blot analysis of brain material from hamsters inoculated IC with (i) fibrillar α-synuclein, (ii, iii) dgPMCAb-derived PrPres induced by WT α-synuclein fibrils or lysates of HeLa cells expressing the A30P variant, (iv) non-fibrillar α-synuclein, or (v) non-seeded dgPMCAb-derived material and stained with SAF-84 (top panels) or 3F4 antibody (bottom panels). Non-inoculated, age-matched animals were examined as a negative control. Brain materials marked by asterisks were used for the second passage. &lt;b&gt;b&lt;/b&gt; Left panel shows Western blot analysis of dgPMCAb-derived PrPres used for inoculation and resulting brain-derived PrPres and PrP&lt;sup&gt;Sc&lt;/sup&gt; from animals of the 1&lt;sup&gt;st&lt;/sup&gt; and 2&lt;sup&gt;nd&lt;/sup&gt; passages. To match the amounts of dgPMCAb- and brain-derived PrPres on a blot, all brain materials were diluted 250-fold after PK treatment. Western blots were stained with SAF-84 antibody. On the right panel is a schematic representation of the PK resistant profile showing overlap between the three glycoforms of PrPres (gray boxes) and the three glycoforms of PrP&lt;sup&gt;Sc&lt;/sup&gt; (black boxes). &lt;b&gt;c&lt;/b&gt; Western blot analysis of brain material from hamsters inoculated with the second passage of dgPMCAb-derived PrPres induced by α-synuclein fibrils; lysates of HeLa cells expressing the A30P mutant; or non-seeded dgPMCAb-derived material. Lanes marked by asterisks show brain material from animals from the first passages used for serial transmission. Western blots were stained with SAF-84 (top panels) or 3F4 antibody (bottom panels).&lt;/p&gt;
Low-Temperature119Sn-Mössbauer Study of Superconducting Bi4Sr3.5Ca2.5Cu4Sn0.015O16-yCeramic (2212 Phase) (1992)

The 119 Sn-Mössbauer spectra of superconducting Bi 4 Sr 3.5 Ca 2.5 Cu 4 Sn 0.015 O 16- y ceramic (2212 phase, T c : 77 K), measured between 298 K and 7 K, consist of singlet peaks of Sn 4+ with the δ ′ s and Γ ′ s of -0.01-0.07 and 1.05-1.27 mm·s -1 , respectively. The ln A (absorption area)-vs- T plot shows that the recoil-free fraction f increases with decreasing temperature, and that the Debye and Einstein temperatures are 340 and 185 K, respectively. The Θ D of 340 K suggests that the Sn 4+ is in the BiO 5 pyramids. The ln A shows a “normal” lattice vibration probably because of the long Cu-O(3) distance and the displacement of O(3).