gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Asymmetric Reduction of α‐Ketoimines with Oxazaborolidine Catalysts: A Novel, Practical Approach to Chiral Arylethanolamines. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Laparoscopic living donor hepatectomy using the left liver  - pushing the limits further (2021)

LV-EV
Impact of sex on diabetic nephropathy and the renal transcriptome in UNx db/db C57BLKS mice (2019)

Diabetic nephropathy (DN) is associated with albuminuria and loss of kidney function and is the leading cause of end-stage renal disease. Despite evidence of sex-associated differences in the progression of DN in human patients, male mice are predominantly being used in preclinical DN research and drug development. Here, we compared renal changes in male and female uninephrectomized (UNx) db/db C57BLKS mice using immunohistochemistry and RNA sequencing. Male and female UNx db/db mice showed similar progression of type 2 diabetes, as assessed by obesity, hyperglycemia, and HbA1c. Progression of DN was also similar between sexes as assessed by kidney and glomerular hypertrophy as well as urine albumin-to-creatinine ratio being increased in UNx db/db compared with control mice. In contrast, kidney collagen III and glomerular collagen IV were increased only in female UNx db/db as compared with respective control mice but showed a similar tendency in male UNx db/db mice. Comparison of renal cortex transcriptomes by RNA sequencing revealed 66 genes differentially expressed (p < .01) in male versus female UNx db/db mice, of which 9 genes were located on the sex chromosomes. In conclusion, male and female UNx db/db mice developed similar hallmarks of DN pathology, suggesting no or weak sex differences in the functional and structural changes during DN progression.
Inflammatory cytokines in serum from children with severe asthma compared to controlled asthmatics (2012)

Introduction : Care of children with severe asthma remains a clinical challenge, partly due to the heterogeneity of the disease and the lack of definite biomarkers. In this study, we compared levels of inflammatory cytokines in serum from children with severe asthma and controlled asthma.

Methods : Children with severe therapy resistant asthma (n=34, mean age 13.3 years) and controlled asthma (n=39, mean age 13.8 years) participated in a nationwide Swedish study. The protocol included Asthma control test, exhaled nitric oxide (FENO) and blood sampling. Interleukin (IL) 4, IL5, IL12p70, tumor necrosis factor alfa (TNFα) and eotaxin were analysed from serum using multiplex technology and results presented as medians with inter quartile ranges (picogram per millilitre).

Results: Severe asthmatic children had inferior asthma control (p 800ug budesonide), compared to children with controlled asthma. FENO (p=0.93) and IgE (p=0.92) were comparable in these two patient groups. Children with severe asthma had increased levels of cytokines related to both Th1 inflammation (IL12p70 4.1 (0-22) vs. 0 (0-4.7), p=0.001 and TNFα 10.4 (4.6-19) vs. 4 (2.1-7.0), p< 0.001)) and to Th2 inflammation (IL4 1.6 (0-29) vs. 0 (0-1.9), p=0.02; IL5 0 (0-1.1) vs. 0 (0-0), p=0.04 and Eotaxin 97.3 (60-146) vs. 49.2 (42-68), p<0.001).

Conclusions: Severe asthmatic children have increased serum levels of cytokines related to both Th1 and Th2 inflammation compared to controlled asthmatics. These results indicate a heterogeneous pattern of inflammation, and multivariate statistical analyses to further characterize the inflammatory phenotypes are initiated.
Alleviation of chronic venous leg ulcers with a hand‐held dielectric barrier discharge plasma generator (PlasmaDerm®VU‐2010): results of a monocentric, two‐armed, open, prospective, randomized and controlled trial (NCT01415622) (2014)

Cold atmospheric plasma displays favourable antibacterial effects. We demonstrated that plasma treatment with the PlasmaDerm® VU-2010 device is safe and effective in patients with chronic venous leg ulcers. Thus, larger controlled trials and the development of devices with larger application surfaces are warranted.
Axicons for Mode Conversion in Higher-Order Mode Fibre Lasers (2015)

Nonlinearities in high-power fibre lasers can be mitigated by increasing the mode effective area (Aeff). Fibre amplifiers designed to operate specifically in a single higher-order mode (HOM) are capable of scaling to effective areas of several thousand square microns, in a format that can be fusion spliced and coiled [1]. A UV-written long-period grating (LPG) converts the input fundamental mode to the desired HOM. Amplification takes place in the HOM, and at the output, reconversion to a diffraction limited beam is achieved with a second LPG matched to the input. The ultra-large area of the HOM fibre enables the generation of record peak powers with low nonlinearity in all-fibre fusion spliced amplifiers [1]. However, in high peak power pulsed systems, reconversion to the fundamental mode before exiting the fibre can add substantially to the nonlinearity in the amplifier [2]. Consequently, a low-nonlinearity, bulk-optic approach to beam conversion at the output of an HOM fibre amplifier would be advantageous for high peak power.
Roller and centrifugal pumps compared in vitro with regard to haemolysis, granulocyte and complement activation (1994)

A Biomedicus centrifugal pump and a Polystan roller pump were compared in vitro with regard to differences in haemolysis, granulocyte and complement activation. Six circuits of tubing and oxygenators were connected to each pump. Heparinized fresh human blood was circulated for 72 hours in the systems. Blood samples were drawn at defined intervals. Haemolysis was assessed by determination of lactate dehydrogenase (LD) and potassium, and granulocyte activation by quantification of the granulocyte proteins calprotectin, lactoferrin and myeloperoxidase. Complement activation was assessed by measuring C3 activation products (C3b, iC3b and C3c), and the terminal C5b-9 complement complex (TCC). The results indicate more haemolysis and complement activation in the roller pump group, revealed by significantly higher concentrations of LD, potassium, C3 activation products and TCC. Calprotectin, lactoferrin and myeloperoxidase were all significantly increased in both groups, but the rise appeared earlier in the roller pump group. The concentrations of LD and potassium both correlated significantly with C3 activation products, indicating that complement activation may at least partly be responsible for the haemolysis.
A Monte Carlo simulation for moving light source in intracavity PDT (2023)

We developed a simulation method for modeling the light fluence delivery in intracavity Photodynamic Therapy (<b>icav-PDT</b>) for pleural lung cancer using a moving light source. Due to the large surface area of the pleural lung cavity, the light source needs to be moved to deliver a uniform dose around the entire cavity. While multiple fixed detectors are used for dosimetry at a few locations, an accurate simulation of light fluence and fluence rate is still needed for the rest of the cavity. We extended an existing Monte Carlo (MC) based light propagation solver to support moving light sources by densely sampling the continuous light source trajectory and assigning the proper number of photon packages launched along the way. The performance of Simphotek GPU CUDA-based implementation of the method - PEDSy-MC - has been demonstrated on a life-size lung-shaped phantom, custom printed for testing icav-PDT navigation system at the Perlman School of Medicine (<b>PSM</b>) - calculations completed under a minute (for some cases) and within minutes have been achieved. We demonstrate results within a 5% error of the analytic solution for multiple detectors in the phantom. PEDSy-MC is accompanied by a dose-cavity visualization tool that allows real-time inspection of dose values of the treated cavity in 2D and 3D, which will be expanded to ongoing clinical trials at PSM. PSM has developed a technology to measure 8-detectors in a pleural cavity phantom using Photofrin-mediated PDT that has been used during validation.
Three‐dimensional volumetric computed tomographic scoring as an objective outcome measure for chronic rhinosinusitis: clinical correlations and comparison to Lund‐Mackay scoring (2013)

Volumetric scoring exhibited higher degree of correlation than Lund-Mackay scoring when comparing improvement in CT score with improvement in score for symptoms, endoscopic exam, and quality of life in this group of patients who received beneficial medical treatment for CRS.
ChemInform Abstract: A Short and Efficient Total Synthesis of (.+‐.)‐Ascofuranone. (2010)

Abstract Ascofuranone (V), a potent inhibitor of trypanosome alternative oxidase, is synthesized in seven steps starting from geranyl acetate.
A facile one-pot synthesis of poly(acrylic acid)-functionalized magnetic iron oxide nanoparticles for suppressing reactive oxygen species generation and adsorption of biocatalyst (2019)

Abstract Functionalized iron oxide nanoparticles (IONPs) have unique physical and chemical properties, which make them potential candidates for biomedical applications. In this study, a facile one-pot method is reported for the preparation of poly(acrylic acid) (PAA) functionalized IONPsthrough in situ free radical solution polymerization of AA and subsequent coprecipitation of Fe 3+ and Fe 2+ ions. The FTIR spectroscopic and TGA results indicated the successful formation and surface functionalization of IONPs with PAA. Electron micrographs showed that the prepared particles were of nano-sized and their shape is dependent on the concentration of PAA. pH-dependent variation of average hydrodynamic diameter confirmed the pH-responsivity of PAA-functionalized IONPs. Magnetic measurement suggested that the PAA functionalized IONPs were strongly paramagnetic (53.0 emug −1 ). Fenton-like catalytic generation is carried out to measure toxicity associated with the nanoparticles. The suppression ability for reactive oxygen species (ROS) generation associated with PAA-functionalized IONPs was studied via methylene blue degradation assay to address their toxicity profile. PAA-functionalized IONPs exhibited better suppression ability than that of the bare IONPs. The adsorption behavior of trypsin was also studied at different pH levels and a maximum adsorption is occurred on PAA-functionalized IONPs at pH 5.0. Catalytic behavior study confirmed higher activity of trypsin immobilized on PAA-functionalized IONPs than that of the reference IONPs. Therefore, the functionalized IONPs can be of high interest for magnetically recyclable biocatalyst carrier.
ChemInform Abstract: Development and Industrialization of Liquid Crystalline Tolans (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Differentially androgen regulated genes in androgen dependent (LNCaP) and independent (C4-2) prostate cancer cells (2005)

4373 Prostate cancer (CaP) ultimately progresses to androgen independence (AI). Development of a lethal phenotype involves enhanced pro-survival cell signaling and altered androgen receptor (AR) function. The diversity of genes implicated in CaP progression is due, in part, to the heterogeneity and multifocal nature of CaP. Gene microarrays evaluated two critical variables involved in acquisition of AI CaP: (1) androgen responsive genes in AR and PSA secreting CaP cells and (2) differential gene expression in LNCaP androgen dependent (AD) and the closely related C4-2 (AI) CaP cells. LNCaP and C4-2 cells were cultured in androgen depleted medium for 2 days followed by treatment with or without 1 nM R1881. Total RNA was compared to control samples on the same chip each containing 14,000 70-mer oligos. Microarray experiments were repeated three times and confirmed by Northern blot and real time-PCR. GeneSpring 6.1 (Silicon Genetics) software was used to profile for significant changes in gene expression. Genes altered by addition (A+) or removal (A-) of androgens were measured as A+/A- and classified as up-regulated (> 1.5 fold) or down-regulated (
Airgap and Line Slope Modeling for Interconnect (2005)

Interconnect is becoming more critical for integrated circuit performance for both memory and logic devices. Backend delay is a significant portion of both routing delay and cell delay. With shrinking dimensions, interconnect lines get closer, resulting in larger coupling and fringing capacitance. For example, line-to-line space for a 65 nm node technology can be as small as 0.11 µm. At these small dimensions, every facet of the manufacturing process matters in modeling interconnect capacitance. Of particular importance are airgaps forming between lines and line slopes – both of which are space dependent. In this work we have developed and applied a generic methodology for capturing void and slope features, based on silicon data, modeled them using a field solver, and utilized their simulation output for potential use in circuit design.
ChemInform Abstract: Syntheses of 2,4‐Diaryl‐2,3‐dihydro‐1,5‐benzothiazepines. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Identification of Inkjet Printers for Forensic Application (2005)

In forensic applications, identification of the source of a printed document can be very critical. However, this task is very challenging, because there are a variety of factors, such as the media type, the age of the printer, and the amount of colorant left in the cartridge that can affect the characteristics of a printed document. For inkjet printers, the availability of different print modes, and the use of variety of ink types adds even more complexity to this process. In this paper, we investigate different texture features of the characters printed by inkjet printers for classification based on text-only documents. We check the in model stability of these features by using a cost function. Finally, we perform stepwise discriminant analysis to reduce the feature set.
Improved Ohmic Contact Model for Accurate Simulation of GaN-based HEMTs Using Ensemble Monte Carlo Methods (2022)

Ensemble Monte Carlo simulation was performed to simulate the current gain cutoff frequency (f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> ) of an AlN/GaN HEMT. It was found that the donor density in the source ohmic neutral region should be larger than 5×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">20</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> to precisely calculate the drain current. The calculation results indicated that as high as 1.6 THz of f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> was achieved with a gate length of 10 nm.
Websigns: hyperlinking physical locations to the Web (2001)

HP researchers are developing handheld devices that combine wireless technology and ubiquitous computing to provide a transparent linkage between physical entities in the environment and resources available on the Web. First-generation mobile computing technologies typically use protocols such as WAP and i-mode to let PDAs, smart phones, and other wireless devices with Web browsers access the Internet, thereby freeing users from the shackles of their desktops. We believe, in addition, users would benefit from having access to devices that combine the advantages of wireless technology and ubiquitous computing to provide a transparent linkage between the physical world around them and the resources available on the Web. We are developing devices that augment users' reality with Web services related to the physical objects they see.
A Distributed and Hybrid Ground Station Network for Low Earth Orbit Satellites (2020)

Low Earth Orbit satellites for Earth observation have become very popular in recent years due to their ability to take high-resolution images of the Earth at high revisit rates. These satellites collect hundreds of GigaBytes of imagery during their orbit. This data needs to be downloaded using ground stations on Earth. However, due to the low altitudes, the satellites move fast with respect to a ground station, and consequently, have a few minutes time window to download the data to a single station. We propose a geographically distributed ground station design, DGS, that improves robustness and reduces downlink latency. DGS is the first system to use a hybrid ground station model, where only a subset of ground stations are uplink-capable. This paper evaluates the feasibility of this design using simulations and empirical measurements.
Delivery Management Effort Allocation Using Learning-Based Profit Estimation (2011)

This manuscript presents a new approach for estimating project's profit based on available data from the same project's past as well as the past available data from all other projects in the same class. We build a statistical model that allows such inference in spite of known erratic financial behavior of services projects. Then, using the estimated profit along with its confidence margin, we propose a strategy for future allocation of project management effort to different projects.
Coarctation of the aorta: collateral flow assessment with phase-contrast MR angiography. (1997)

Phase-contrast MR angiography is an excellent technique for detecting the presence or absence of collateral blood flow in the intercostal arteries of patients with coarctation of the aorta. Knowing whether collateral blood flow is present in patients with narrowing of the juxtaductal aorta should help assess the clinical hemodynamic significance of the coarctation.
Eosinophil Cysteinyl Leukotriene Synthesis Mediated by Exogenous Secreted Phospholipase A2 Group X (2010)

Secreted phospholipase A(2) group X (sPLA(2)-X) has recently been identified in the airways of patients with asthma and may participate in cysteinyl leukotriene (CysLT; C(4), D(4), and E(4)) synthesis. We examined CysLT synthesis and arachidonic acid (AA) and lysophospholipid release by eosinophils mediated by recombinant human sPLA(2)-X. We found that recombinant sPLA(2)-X caused marked AA release and a rapid onset of CysLT synthesis in human eosinophils that was blocked by a selective sPLA(2)-X inhibitor. Exogenous sPLA(2)-X released lysophospholipid species that arise from phospholipids enriched in AA in eosinophils, including phosphatidylcholine, phosphatidylinositol, and phosphatidylethanolamine as well as plasmenyl phosphatidylcholine and phosphatidylethanolamine. CysLT synthesis mediated by sPLA(2)-X but not AA release could be suppressed by inhibition of cPLA(2)α. Exogenous sPLA(2)-X initiated Ser(505) phosphorylation of cPLA(2)α, an intracellular Ca(2+) flux, and translocation of cPLA(2)α and 5-lipoxygenase in eosinophils. Synthesis of CysLTs in response to sPLA(2)-X or lysophosphatidylcholine was inhibited by p38 or JNK inhibitors but not by a MEK 1/2 inhibitor. A further increase in CysLT synthesis was induced by the addition of sPLA(2)-X to eosinophils under conditions of N-formyl-methionyl-leucyl-phenylalanine-mediated cPLA(2)α activation. These results indicate that sPLA(2)-X participates in AA and lysophospholipid release, resulting in CysLT synthesis in eosinophils through a mechanism involving p38 and JNK MAPK, cPLA(2)α, and 5-lipoxygenase activation and resulting in the amplification of CysLT synthesis during cPLA(2)α activation. Transactivation of eosinophils by sPLA(2)-X may be an important mechanism leading to CysLT formation in the airways of patients with asthma.
Role for Therapeutic Drug Monitoring During Induction Therapy with TNF Antagonists in IBD (2014)

: Primary nonresponse and primary nonremission are important limitations of tumor necrosis factor (TNF) antagonists, occurring in 10% to 40% and 50% to 80% of patients with inflammatory bowel disease, respectively. The magnitude of primary nonresponse differs between phase III clinical trials and cohort studies, indicating differences, e.g., in definition, patient population or blinding. The causes of nonresponse can be attributed to the drug (pharmacokinetics, immunogenicity), the patient (genetics, disease activity), the disease (type, location, severity), and/or the treatment strategy (dosing regimen, combination therapy). Primary nonresponse has been attributed to "non-TNF-driven disease" which is an overly simplified and potentially misleading approach to the problem. Many patients with primary nonresponse could successfully be treated with dose optimization during the induction phase or switching to another TNF antagonist. Therefore, primary nonresponse is frequently not a non-TNF-driven disease. Recent studies from rheumatoid arthritis and preliminary data from inflammatory bowel disease evaluating therapeutic drug monitoring have suggested that early measurement of drug and anti-drug antibody concentrations could help to define primary nonresponse and rationalize patient management of this problem. Moreover, a modeling approach including pharmacological parameters and patient-related covariants could potentially be predictive for response to the treatment. We describe an overview of this evolution in thinking, underpinned by previous findings, and assess the potential role of early measurement of drug and antidrug antibody concentrations in the definition and management of primary nonresponse.
Design and Performance of the SOAR Primary Mirror Calibration Wavefront Sensor (2003)

Adaptive Optics Associates has designed and built the Southern Astrophysical Research (SOAR) telescope primary mirror calibration wavefront sensor. It will be used to monitor the figure of the active primary mirror during observations. The package also includes an acquisition camera subsystem. The sensor uses many commercial components to control cost while meeting the desired technical specifications. We describe the wavefront sensor system and present results of performance testing obtained in the laboratory.
Simulated imaging properties of a series of magnetic electron lenses (1995)

The paraxial lens data were determined for a series of symmetrical magnetic lenses of equal lens diameter but variable air gap width for a wide range of lens excitations using the three-dimensional electrodynamic computer code MAFIA. The results are compared with a similar study done by Liebman and Grad wherein the field distributions within the lenses were measured experimentally with a resistance network analogue. Using these fields the lens data were obtained through numerical trajectory tracing. The utility of using MAFIA, instead of experimental methods for lens design is shown by the excellent agreement of the simulated results compared to experiment. Also demonstrated is the capability of using MAFIA to investigate aberration sources such as higher order off-axis magnetic field and space-charge effects.
Supplementary Fig. S.4 from NK-Cell Recruitment Is Necessary for Eradication of Peritoneal Carcinomatosis with an IL12-Expressing Maraba Virus Cellular Vaccine (2023)

&lt;p&gt;Intra-tumoral vaccination is essential to maximize the benefit of MG1-IL12-ICV vaccine.&lt;/p&gt;