gebhart/patrepeval huggingface dataset:
Regioselective Oxidative Coupling of 4-Hydroxystilbenes:  Synthesis of Resveratrol and ε-Viniferin (E)-Dehydrodimers (2004)

Treatment of 5-[2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol (resveratrol) with an equimolar amount of silver(I) acetate in dry MeOH at 50 degrees C for 1 h followed by chromatographic purification with a short silica gel column allowed the isolation of its (E)-dehydrodimer, 5-[5-[2-(3,5-dihydroxyphenyl)vinyl]-2-(4-hydroxyphenyl)-2,3-dihydrobenzofuran-3-yl]benzene-1,3-diol, as a racemic mixture in high yield. The present method was applicable to the oxidative dimerization of 4-hydroxystilbenes such as trans-styrylphenol and 5-[6-hydroxy-2-(4-hydroxyphenyl)-4-[2-(4-hydroxyphenyl)vinyl]-2,3-dihydrobenzofuran-3-yl]benzene-1,3-diol (epsilon-viniferin) leading to the corresponding 2-(4-hydroxyphenyl)-2,3-dihydrobenzofurans possessing various types of biological activities.
Essential oil composition of Cymbopogon martinii from different places in India (2003)

Abstract The essential oils of Palmarosa ( Cymbopogon martinii (Roxb.) Wats. var. motia Burk) ﬂowering herbs from three different geographical locations in India, viz. Hyderabad,Lucknow and Amarawati were analysed by high‐resolution GC and GC –MS. In all three samples, geraniol (67.6 –83.6%) was the major constituent and, although the composition of the three oils was similar, quantitative differences in the concentration of some constituents were observed. The GC and GC –MS analysis of the Hyderabad, Lucknow and Amarawati oils resulted in the identiﬁcation of 40, 38 and 33 constituents, representing 98.5%, 99.7% and 99.8% of the oils,respectively. Among the three oils analysed, Amarawati oil was of the highest quality due to higher geraniol (83.6%) and lower geranyl acetate (2.3%) and geranial (1.0%) content. Copyright © 2003 John Wiley &amp; Sons, Ltd.
Graphene-Based Terahertz Waveguide Modulators (2015)

We report two proof-of-principle designs of silicon terahertz (THz) modulators based on guiding structures wherein graphene is introduced to actively control the properties of the waveguides, thus tuning their transmissivity. Using well-established models to characterize the electromagnetic parameters of electrically-doped graphene, we estimate the theoretical performance of the proposed structures, in particular the required switching voltage and the achievable modulation depth. These results predict considerably improved performance with respect to the state-of-the-art of graphene THz modulators, together with reduced size and larger THz bandwidth.
Predicting Progression ofABCA4-Associated Retinal Degenerations Based on Longitudinal Measurements of the Leading Disease Front (2015)

The eccentricity of the LDF in ABCA4-RD shows a continuum from parafovea to far periphery along all four meridians consistent with a wide spectrum of severity observed clinically. The model of progression may provide a quantitative prediction of the LDF expansion based on the age and eccentricity of the LDF at a baseline visit, and thus contribute significantly to the enrollment of candidates appropriate for clinical trials planning specific interventions, efficacy outcomes, and durations.
3D-printing nanocrystals with light (2022)

Nanocrystals are connected to form complex 3D structures by means of two-photon lithography.
Optimal interconnect circuits for VLSI (1984)

THE PROPAGATION DELAY of interconnects is a major factor determining the performance of VLSI circuits, because the RC time constant of interconnects increases very rapidly as chip and interconnect dimensions are scaled aggressively. In this paper a simple model for interconnect time delay, including the effects of scaling transistor, interconnect and chip dimensions will be discussed. To reduce interconnect time delay, properly-scaled multilevel conductors, repeaters, cascaded drivers, and cascaded drivers as repeaters are presented. The delay model yields optimum cross sectional interconnect dimensions and driver/ repeater configurations that can reduce interconnect time delays by more than an order of magnitude
A control strategy to stabilize PWM dc-dc converters with input filters using state-feedback and pole-placement (2008)

LC filters at the input of dc-dc converters can lead to instabilities due to filter interactions with the converter control. Conventional methods to remedy this issue usually employ external resistors to damp filter oscillations. However such dissipative damping of input filter degrades the converter efficiency. In this paper we propose an alternate solution to this problem using a full state-feedback controller combined with a PI-control. This control algorithm assures stability of the system without using any passive components in the filter circuit and thus avoiding any undesirable losses. Moreover it guarantees adequate level of performance using a varying gain state-feedback and pole-placement. Simulation studies are carried out to confirm the effectiveness of the suggested control strategy under large perturbations.
Gross total resection or debulking of pituitary adenomas improves hormonal control of acromegaly by somatostatin analogs (2005)

Gross total tumor resection or debulking increases the likelihood of achieving biochemical disease control with SSAs in acromegalic patients with adenomas that were not amenable to complete surgical resection and in whom primary SSA therapy was unable to achieve good biochemical control.
Technical Design Report for the Phase-I Upgrade of the ATLAS TDAQ System (2013)

The Phase-I upgrade of the ATLAS Trigger and Data Acquisition (TDAQ) system is to allow the ATLAS experiment to efficiently trigger and record data at instantaneous luminosities that are up to three times that of the original LHC design while maintaining trigger thresholds close to those used in the initial run of the LHC.
B-34 The influence of Inertia of Club Head for Shaft Movement (2015)

In order to hit golf balls correctly, golfers are particularly concerned with the characteristics of their drivers. Therefore, golf clubs are designed to satisfy golfers' demands. However, the United States Golf Association has placed restrictions not only on the volume of the club head, but also on the coefficient of the golf club under the spring effect rule. It is therefore difficult to differentiate these specifications. Golf club developers use a variety of methods to customize clubs to individual golfer. One such technique is "database fitting," established by Sumitomo Rubber Industries, Ltd. (SRI). In the future, golf club developers would like to provide shafts customized to fit each individual golfer. In order to do so, it is necessary to predict shaft movement during a golf swing via simulation. Previous studies simulating shaft movement during a golf swing demonstrate shaft movement using a finite element method (FEM) model. A head was attached to a FEM model of the shaft as a simplified ridig model. Moreover to take the golfer's grip into consideration, we modelled the grip using potential grip energy during the swing. Using this simulation model, we simulated shaft movement while taking into account the golfer's swing. And resolving inertia force into its component elements, we simulated shaft movement. The objectives of this study are to verify the influence of the component of inertia force on shaft movement while taking into account the golfer's swing.
Effect of Field of View in Stereovision-Based Visual Homing (2017)

Navigation is challenging for an autonomous robot operating in an unstructured environment. Visual homing is an AI local navigation technique used to direct a robot to a previously seen location, and is inspired by biological models. Most visual homing uses a panoramic camera. Prior work has shown that exploiting depth cues in homing from, e.g., a stereo-camera, leads to improved performance. However, many stereo-cameras have a limited field of view (FOV). We present a stereovision database methodology for visual homing. We use two databases we have collected, one indoor and one outdoor, to evaluate the effect of FOV on the performance of our homing with stereovision algorithm. Based on over 120,000 homing trials, we show that contrary to intuition, a panoramic field of view does not necessarily lead to the best performance, and we discuss the implications of this.
Innovating vaccines: From gene expression to translational entrepreneurship (2010)

Born 1950 in the small town of Coburg in post-war West Germany, I was surrounded by a strange mindset that was coded by a "Gemisch" of "Verdrängung" of the country's Nazi past and by a blind optimism that the divided country-in spite of the cruelties and the horrors of the war and the Nazi period-could be rebuilt and regain the respect of other nations. Luckily, I was raised in a family where the reality of destruction and Nazi crimes of the past were openly discussed and not suppressed; the exodus and deportation of Jewish citizens and concentration camps such as Auschwitz were not taboo topics.
Studies on the Components of the Folk Medicine, Kaju Ular, in Timor Island (1982)

Nine Strychnos alkaloids were isolated from the trunk without bark of Kaju Ular, a folk medicine in Timor island, whose original plant is assumed to be Strychnos ligustrina : strychnine, brucine, β-colubrine, ψ-strychnine, ψ-brucine, ψ-β-colubrine, strychnine N-oxide, brucine N-oxide and β-colubrine N-oxide. They were identified by direct comparison with authentic samples. This is the first report of isolation of ψ-strychnine, ψ-β-colubrine, and β-colubrine N-oxide from the trunk of S. ligustrina. Reassignment of 13C-nuclear magnetic resonance spectra of those alkaloids were made by use of the additivity rule and by considerating the effects caused by the introduction of oxygenated function at C-16 and at N-19. The result supported the previous assignment by Wenkert et al.
Closed-Loop Control of a Three-Port Series Resonant Converter (2021)

The three port series resonant converter (3pSRC) is a promising topology especially for grid applications and onboard chargers. It offers galvanic isolation, high efficiency and enables a power dense design via the common multiport transformer structure. Typically, power flow is controlled by means of the switching frequency and/or the relative phase between the excitation of each transformer port. However a unique solution for the optimal combination of control variables for any unique set of port voltages and powers is non trivial. This paper proposes a control loop for naturally approximating such optimal control variables. The mathematical model used for calculating the power flow between the three ports is presented and a method for finding the switching frequency that best balances zero-voltage-switching (ZVS) and high efficiency for a given operation point is given. The control approach is demonstrated with a Silicon Carbide (SiC) based prototype for an on-board charger application.
Antitrypanosomal and antiplasmodial activity of bis(2-aminoimidazoline) and bisguanidine derivatives (2008)

Recent findings by our group have shown that bisguanidine and especially bis(2-aminoimidazoline)diphenyl compounds displayed potent antitrypanosomal activity in vitro [1] and vivo [2] against T. b. rhodesiense, the causative agent of acute human African trypanosomiasis (HAT). These studies revealed that molecules bearing 2-aminoimidazoline cations had higher selectivity for the parasite and similar activities with respect to their guanidine counterparts. In addition, a correlation between antitrypanosomal activity and DNA binding affinity was observed, suggesting a possible mechanism of action for these compounds [2]. Last but not least, we showed that this kind of molecules entered into trypanosomes via different transporters in addition to P2, indicating that parasites that have lost the P2 transporter in selection of resistance to other drugs will not show cross-resistance to this class of molecules. Encouraged by these promising results, another series of 16 dicationic analogues were evaluated in vitro against T. b. rhodesiense (STIB900). Moreover, in order to extend our understanding of the SAR of this class of antiprotozoal agents, two new series of monocationic analogues, namely 2-aminoimidazolinium compounds and their guanidinium counterparts were assayed.&#13;\nOthers have described excellent antiplasmodial activity of related aromatic dicationic structures such as pentamidine or DB289 [3] These findings prompted us to test the antiplasmodial potential of our dicationic diphenyl compounds. The capacity of the compounds to inhibit the formation of hemozoin, as a possible mechanism of action, was also evaluated in vitro with the ferriprotoporphyrin IX binding inhibition test (FBIT) [4].&#13;\nReferences: [1]\tDardonville, C.; Brun, R. J Med Chem 2004, 47, 2296. [2]\tDardonville, C.; Barrett, M. P.; Brun, R.; Kaiser, M.; Tanious, F.; Wilson, W. D. J Med Chem 2006, 49, 3748. [3]\tSoeiro, M. N. C.; De Souza, E. M.; Stephens, C. E.; Boykin, D. W. Expert Opin Inv Drug 2005, 14, 957. [4]\tDeharo, E.; Garcia, R. N.; Oporto, P.; Gimenez, A.; Sauvain, M.; Jullian, V.; Ginsburg, H. Exp Parasitol 2002, 100, 252.
Human B cell precursors proliferate and express CD23 after CD40 ligation. (1993)

The CD40 surface membrane molecule plays an important role in the activation of mature human B cells, but its role in earlier stages of B lineage development is unknown. Here, we have investigated the effects of triggering the CD40 antigen on B cell precursors (BCP) by crosslinking with anti-CD40 antibody presented by Fc gamma-receptor type II-transfected murine Ltk- cells (CD40 system). CD10+ surface immunoglobulin negative (sIg-) BCP, freshly isolated from fetal bone marrow or precultured on stromal cells, proliferated in the CD40 system. This effect required the presence of IL-3, which acted as a specific cosignal among a panel of cytokines examined. The association of IL-10 and IL-7 potentiated the observed IL-3 and CD40-dependent BCP proliferation, demonstrating that IL-10 can act on early B lineage cells. CD40-dependent activation of fetal BCP did not favor maturation to sIg+ B cells, but resulted in the induction of high levels of surface membrane CD23. The emerging CD23+ BCP lacked sIg and CD10, and represented an important proportion of the cycling cells in the CD40-dependent cultures. Taken together, our data demonstrate that stimulation of the CD40 antigen induces expression of the CD23 gene, and regulates cell proliferation during normal human B cell ontogeny.
The virtual retinal display as a low-vision computer interface: a pilot study. (2002)

This pilot study examined the performance of an alternative computer visual interface, the Virtual Retinal Display (VRD), for low-vision use. The VRD scans laser light directly onto the retina, creating a virtual image. Since visually impaired individuals can have difficulty using computer displays, a matched comparison study was done between the VRD and the standard cathode ray tube (CRT) monitor. Reading speed and acuity tests were collected from 13 low-vision volunteers selected to represent the broad range of partially sighted individuals actively involved in the work force. Forty-six percent of subjects had highest visual acuity while viewing the VRD; 30% of subjects had highest acuity viewing the CRT; and 24% of subjects had equal acuity across the two displays. Although mean reading speed across all 13 subjects indicated no significant difference between displays, individual subjects with predominantly optical causes of low vision exhibited clinically important increases in reading speed versus the CRT. However, most subjects with predominantly retinal damage showed a slight disadvantage using the VRD. We give theoretical explanation to the bifurcated results and conclude that for a subset of low-vision users, the VRD technology is very promising as a basis for future low-vision aids.
Data Allocation Algorithm based on Write and Read Frequency for Double Asymmetric-latency SCM SSD (2020)

Storage class memories (SCMs) realize fast access latency. However, SCMs have a trade-off between reliability and latency in case of correcting errors. To achieve high reliability and high performance, double asymmetric-latency SCM SSD has been proposed. Previously proposed SSD consists of fast-write/slow-read SCM (W-SCM) and fast-read/slow-write SCM (R-SCM). W-SCM and R-SCM are realized by changing strength of ECC and number of Set/Reset verify cycles by SSD controller. Previously proposed SSD with asymmetric read/write latency requires frequently written (write-hot) data to be allocated in W-SCM and frequently read (read-hot) data to be allocated in R-SCM to achieve high performance [1]. Conventional data allocation algorithm for previously proposed SSD [1] triggers frequently data movement and degrades SSD performance. Therefore, this paper proposes data allocation algorithm that restricts data movement and stores write-hot, read-hot and cold data separately in W-SCM and R-SCM based on access frequency. As a result, SSD performance is improved by 14.1% for write-hot workload and 67.7% for read-hot workload compared to conventional algorithm.
Active inductor shunt peaking in high-speed VCSEL driver design (2013)

An all transistor active inductor shunt peaking structure has been used in a prototype of 8-Gbps high-speed VCSEL driver which is designed for the optical link in ATLAS liquid Argon calorimeter upgrade. The VCSEL driver is fabricated in a commercial 0.25-um Silicon-on-Sapphire (SoS) CMOS process for radiation tolerant purpose. The all transistor active inductor shunt peaking is used to overcome the bandwidth limitation from the CMOS process. The peaking structure has the same peaking effect as the passive one, but takes a small area, does not need linear resistors and can overcome the process variation by adjust the peaking strength via an external control. The design has been tapped out, and the prototype has been proofed by the preliminary electrical test results and bit error ratio test results. The driver achieves 8-Gbps data rate as simulated with the peaking. We present the all transistor active inductor shunt peaking structure, simulation and test results in this paper.
Supplementary Figure S3 from Bispecific Antibodies and Antibody–Drug Conjugates (ADCs) Bridging HER2 and Prolactin Receptor Improve Efficacy of HER2 ADCs (2023)

&lt;p&gt;PRLR degradation was not significantly affected by PRLR antibody or Prolactin (PRL).&lt;/p&gt;
Faculty Opinions recommendation of Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein. (2019)

Age-related neurodegenerative disorders are characterized by slow, persistent accumulation of aggregated proteins. Although cells can elicit physiological responses to enhance cellular clearance and counteract accumulation, it is unclear how pathogenic proteins evade this process in disease. We find that Parkinson's disease a-synuclein perturbs the physiological response to lysosomal stress by impeding SNARE protein ykt6. Cytosolic ykt6 is normally autoinhibited by a unique farnesyl-mediated regulatory mechanism however during lysosomal stress, it activates and redistributes into membranes to preferentially promote hydrolase trafficking and enhance cellular clearance. a-Synuclein aberrantly binds and deactivates ykt6 in patient-derived neurons, thereby disabling the lysosomal stress response and facilitating protein accumulation.
Serpulina pilosicoli, waterbirds and water: potential sources of infection for humans and other animals (1998)

Serpulina pilosicoli was isolated from 8 of 43 (19%) faecal specimens obtained from feral waterbirds sampled around a small lake at Perth Zoological Gardens, Western Australia, and from 3 of 7 (43%) samples of the lake water. The organism was only isolated from 1 of 204 (0.5%) samples from captive birds and animals in the zoological collection. Multilocus enzyme electrophoresis analysis of the isolates showed that they were genetically diverse, and none had identical electrophoretic profiles as those previously obtained from human beings, dogs, pigs and other avian species. To determine the survival time of S. pilosicoli in water, cells of strain 1648 were seeded into lake and tap water, and incubated at 4, 25 and 37 degrees C. The organism could be recultured from lake water for up to 66 days at 4 degrees C, and for 4 days at 25 degrees C. A healthy human volunteer who drank water seeded with S. pilosicoli strain Wes B became colonized, and developed abdominal discomfort and headaches. Contamination of water by faeces may represent a source of S. pilosicoli infection for both humans and animals.
Single photon generation with optically excited quantum dots (2004)

Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text C. Santori, "Single photon generation with optically excited quantum dots," in Conference on Lasers and Electro-Optics/International Quantum Electronics Conference and Photonic Applications Systems Technologies, Technical Digest (CD) (Optica Publishing Group, 2004), paper IWE1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Causal relationships between migraine and microstructural white matter: a Mendelian randomization study (2023)

Our findings provided genetic evidence for the causal relationships between migraine and microstructural WM, bringing new insights into brain structure for the development and experience of migraine.
Enhanced Binding of Peripheral Blood Mononuclear Leukocytes to γ-Interferon-Treated Cultured Keratinocytes (1987)

Dermatopathologists observe mononuclear leukocytes in close apposition to keratinocytes (KCs) in graft versus host disease and in other lymphocyte-mediated skin diseases, such as lichen planus, erythema multiforme, and lupus erythematosus. Since the KCs are Class II histocompatibility antigen (HLA-DR) positive in these diseases (indicating local production of gamma interferon, IFN-gamma, by activated T-cells), we sought to determine whether IFN-gamma treatment of KCs would influence the ability of allogeneic peripheral blood mononuclear leukocytes (PBMLs) to adhere to cultured KCs in vitro. The adherence of PBMLs to KC monolayers was determined by the three following methods: (a) methanol fixation of the washed KCs (after PBML incubation), followed by hematoxylin-eosin staining and direct counting of adherent PBMLs; (b) fluorescein isothiocyanate (FITC) labeling of PBML, followed by measuring the amount of FITC-PBML bound to KCs after washing either by direct visualization with a fluorescence microscope; or by (c) quantitative fluorescence spectroscopy following lysis of the adherent cells. While untreated KCs bound allogeneic PBMLs minimally 15-120 min at 37 degrees C, pretreatment of the KCs with IFN-gamma (300 U/ml, 3 days) produced significantly increased binding of the PBMLs by approximately fivefold. By contrast, IFN-alpha and IFN-beta (10(3) U/ml) had no effect. Also, despite the induction of HLA-DR on cultured human fibroblasts, no increased binding of PBMLs after IFN-gamma treatment was observed. The selective ability of IFN-gamma to produce a marked increase in adherence between KCs and PBMLs suggests a new role for IFN-gamma in the immunobiology of the skin.