gebhart/patrepeval huggingface dataset:
Delayed Disease Onset and Extended Survival in the SOD1G93ARat Model of Amyotrophic Lateral Sclerosis after Suppression of Mutant SOD1 in the Motor Cortex (2014)

Sporadic amyotrophic lateral sclerosis (ALS) is a fatal disease with unknown etiology, characterized by a progressive loss of motor neurons leading to paralysis and death typically within 3-5 years of onset. Recently, there has been remarkable progress in understanding inherited forms of ALS in which well defined mutations are known to cause the disease. Rodent models in which the superoxide dismutase-1 (SOD1) mutation is overexpressed recapitulate hallmark signs of ALS in patients. Early anatomical changes in mouse models of fALS are seen in the neuromuscular junctions (NMJs) and lower motor neurons, and selective reduction of toxic mutant SOD1 in the spinal cord and muscle of these models has beneficial effects. Therefore, much of ALS research has focused on spinal motor neuron and NMJ aspects of the disease. Here we show that, in the SOD1(G93A) rat model of ALS, spinal motor neuron loss occurs presymptomatically and before degeneration of ventral root axons and denervation of NMJs. Although overt cell death of corticospinal motor neurons does not occur until disease endpoint, we wanted to establish whether the upper motor neuron might still play a critical role in disease progression. Surprisingly, the knockdown of mutant SOD1 in only the motor cortex of presymptomatic SOD1(G93A) rats through targeted delivery of AAV9-SOD1-shRNA resulted in a significant delay of disease onset, expansion of lifespan, enhanced survival of spinal motor neurons, and maintenance of NMJs. This datum suggests an early dysfunction and thus an important role of the upper motor neuron in this animal model of ALS and perhaps patients with the disease.
Search for top-squark pair production in the single-lepton final state in pp collisions at $\sqrt{s}=8\ \mathrm{TeV}$ (2013)

This paper presents a search for the pair production of top squarks in events with a single isolated electron or muon, jets, large missing transverse momentum, and large transverse mass. The data sample corresponds to an integrated luminosity of 19.5 fb -1 of pp collisions collected in 2012 by the CMS experiment at the LHC at a center-ofmass energy of s = 8 TeV. No significant excess in data is observed above the expectation from standard model processes. The results are interpreted in the context of supersymmetric models with pair production of top squarks that decay either to a top quark and a neutralino or to a bottom quark and a chargino. For small mass values of the lightest supersymmetric particle, top-squark mass values up to around 650 GeV are excluded.
Group 3 Metal Complexes of Salen-like Fluorous Dialkoxy−Diimino Ligands: Synthesis, Structure, and Application in Ring-Opening Polymerization of rac-Lactide and rac-β-Butyrolactone (2008)

The coordination chemistry of the dianionic fluorous dialkoxy−diimino ligand {OC(CF3)2CH2C(Me)═NCH2CH2N═C(Me)CH2C(CF3)2O}2− ({ONEtNO}2−) onto Y(III) and La(III) centers has been studied. The diimino−diol {ONEtNO}H2 reacts with 1 equiv of Y(N(SiHMe2)2)3·2THF to afford {ONEtNO}Y(N(SiHMe2)2)(THF) (1). Complex 1 slowly decomposes in solution, forming as yet undefined products, but could be stabilized by further reaction with 1 equiv of (R)-(+)-tert-butyl lactate, to give selectively [{ONEtNO}Y((R)-tBu-lactate)]2 (2) in 78% yield. A single-crystal diffraction study revealed that 2 is dinuclear in the solid state, with bridging μ,κ2O,O,O-lactate units and tetracoordinated {ONEtNO} units. The same geometry is retained in THF-d8 solution, as indicated by 1H, 13C, and 19F NMR spectroscopy. Reaction of {ONEtNO}H2 with 1 equiv of La(N(SiHMe2)2)3·2THF or La(N(SiMe3)2)3 systematically yielded {ONEtNO}La{ONEtNOH} (3), which was characterized by single-crystal X-ray diffraction and NMR studies. Complex 2 is an effective initiator for the controlled-“living” ring-opening polymerization of rac-lactide and rac-β-butyrolactone, giving atactic polymers with high molecular weights (Mn up to 55 000 g mol−1) that match well the calculated values and relatively narrow polydispersities (Mw/Mn = 1.06−1.60). The immortal ROP of rac-lactide appears feasible by combining complex 2 with 5 equiv of 2-propanol.
ChemInform Abstract: Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Accessible Pool and System Parameters: Assumptions and Models (1991)

Quantitative assessment of substrate metabolism from in vivo tracer kinetic data requires a model of the system, i.e., a hypothesis on the structure and functioning of the system. Some fundamentals of modeling important for studying intermediary metabolism in the steady state will be discussed. Accessible pool and system parameters are defined. Although the calculation of accessible pool parameters is structure-free, that of system parameters requires the use of non-compartmental or compartmental structures. Assumptions, bases for choice, and relative merits of these two modeling strategies are discussed. Glucose and leucine metabolism serve as prototypes to illustrate the theoretical points.
Qishen Yiqi Dripping Pills for Chronic Ischaemic Heart Failure: Results of the CACT-IHF Randomized Clinical Trial (2020)

Treatment with QSYQ for 6 months in addition to standard therapy improved exercise tolerance of IHF patients and was well tolerated.
nBIIG: A Neural BI Insights Generation System for Table Reporting (2022)

We present nBIIG, a neural Business Intelligence (BI) Insights Generation system. Given a table, our system applies various analyses to create corresponding RDF representations, and then uses a neural model to generate fluent textual insights out of these representations. The generated insights can be used by an analyst, via a human-in-the-loop paradigm, to enhance the task of creating compelling table reports. The underlying generative neural model is trained over large and carefully distilled data, curated from multiple BI domains. Thus, the system can generate faithful and fluent insights over open-domain tables, making it practical and useful.
Scanner Based Spectrum Estimation of Inkjet Printed Colors (2011)

Fast and accurate color measurement devices would have benefitted printing in general and specifically commercial and industrial printing presses, however, such devices are expensive and are therefore not always available. On the other hand, a scanner is cheap and available in most print services providers, and is sometimes even integrated in the output paper path of commercial presses, e.g. the HP7500 press. It is commonly agreed that scanners are not color measurement devices - certainly not accurate ones. This paper shows feasibility of providing printer output spectrum estimation using a scanner as the measuring device. Such a method could further be used for colorimetry and color characterization. To do that we need to estimate the color specification of a scanner - or - the mapping function from the spectrum to the scanner measurements, which we will consequently invert. Unlike traditional methods that ignore the printing process, we propose to use the printer color model as a prior knowledge to perform accurate spectrum estimation. The applicability generality and high quality of the proposed method are demonstrated on two different printing processes: a Thermal Inkjet printer and an LEP (HP Indigo) press.
Combined Measurement of the Higgs Boson Mass inppCollisions ats=7and 8 TeV with the ATLAS and CMS Experiments (2015)

A measurement of the Higgs boson mass is presented based on the combined data samples of the ATLAS and CMS experiments at the CERN LHC in the H→γγ and H→ZZ→4ℓ decay channels. The results are obtained from a simultaneous fit to the reconstructed invariant mass peaks in the two channels and for the two experiments. The measured masses from the individual channels and the two experiments are found to be consistent among themselves. The combined measured mass of the Higgs boson is m_{H}=125.09±0.21 (stat)±0.11 (syst) GeV.
Mechanism of apical K+ channel modulation in principal renal tubule cells. Effect of inhibition of basolateral Na(+)-K(+)-ATPase. (1993)

The effects of inhibition of the basolateral Na(+)-K(+)-ATPase (pump) on the apical low-conductance K+ channel of principal cells in rat cortical collecting duct (CCD) were studied with patch-clamp techniques. Inhibition of pump activity by removal of K+ from the bath solution or addition of strophanthidin reversibly reduced K+ channel activity in cell-attached patches to 36% of the control value. The effect of pump inhibition on K+ channel activity was dependent on the presence of extracellular Ca2+, since removal of Ca2+ in the bath solution abolished the inhibitory effect of 0 mM K+ bath. The intracellular [Ca2+] (measured with fura-2) was significantly increased, from 125 nM (control) to 335 nM (0 mM K+ bath) or 408 nM (0.2 mM strophanthidin), during inhibition of pump activity. In contrast, cell pH decreased only moderately, from 7.45 to 7.35. Raising intracellular Ca2+ by addition of 2 microM ionomycin mimicked the effect of pump inhibition on K+ channel activity. 0.1 mM amiloride also significantly reduced the inhibitory effect of the K+ removal. Because the apical low-conductance K channel in inside-out patches is not sensitive to Ca2+ (Wang, W., A. Schwab, and G. Giebisch, 1990. American Journal of Physiology. 259:F494-F502), it is suggested that the inhibitory effect of Ca2+ is mediated by a Ca(2+)-dependent signal transduction pathway. This view was supported in experiments in which application of 200 nM staurosporine, a potent inhibitor of Ca(2+)-dependent protein kinase C (PKC), markedly diminished the effect of the pump inhibition on channel activity. We conclude that a Ca(2+)-dependent protein kinase such as PKC plays a key role in the downregulation of apical low-conductance K+ channel activity during inhibition of the basolateral Na(+)-K(+)-ATPase.
Synthesis and Properties of Fluorescent NF-κB-Recognizing Hairpin Oligodeoxyribonucleotide Decoys (2004)

Intramolecular fluorescence quenching of cyanine dyes was investigated using a model hairpin oligonucleotide decoy encoding a NF-kappaB p50 subunit binding site. Two types of hairpin oligonucleotides were synthesized: (1) 5'-(6-aminohexyl)- and 3'-(3-aminopropyl)-linked (I); (2) 5'-(6-aminohexyl)- and 3'-[3-(3-hydroxypropyldithio)propyl]-linked (II). Oligonucleotide I was covalently modified using monofunctional either Cy3- or Cy5.5-N-hydroxysuccinimide esters. Using reverse-phase HPLC, mono-and dicyanineamide derivatives of I were isolated. Mono-Cy3-modified derivatives of I, but not the mono-Cy5.5-modified derivatives, showed a 2-fold higher Cy3 fluorescence intensity compared to the free dye. There was no detectable difference in fluorescence between the di-Cy3 derivative of I and the free dye at the same concentration. However, there was a 4-fold quenching of fluorescence in the case of the di-Cy5.5 derivative of the same hairpin oligonucleotide. The quenching of Cy5.5 fluorescence could not be explained by the interaction of Cy5.5 with nucleotide bases as demonstrated by incubating free Cy5.5 dye with oligonuclotides. The quenching effect was further investigated using an oligonucleotide bearing a cleavable 3'-amino-terminated linker bearing an S-S bond (III). After modification of the 5'- and 3'-end of oligonucleotide III with a Cy5.5 monofunctional hydroxysuccinimide ester, a 70-75% quenching of fluorescence was observed. Fluorescence was 100% dequenched after the reduction of S-S bond. The obtained result unequivocally demonstrates that the formation of intramolecular Cy5.5 dimers is the dominant mechanism of fluorescence quenching in symmetric dye-dye hairpin decoy beacons.
Video textures (2000)

This paper introduces a new type of medium, called a video texture, which has qualities somewhere between those of a photograph and a video. A video texture provides a continuous infinitely varying stream of images. While the individual frames of a video texture may be repeated from time to time, the video sequence as a whole is never repeated exactly. Video textures can be used in place of digital photos to infuse a static image with dynamic qualities and explicit actions. We present techniques for analyzing a video clip to extract its structure, and for synthesizing a new, similar looking video of arbitrary length. We combine video textures with view morphing techniques to obtain 3D video textures. We also introduce video-based animation, in which the synthesis of video textures can be guided by a user through high-level interactive controls. Applications of video textures and their extensions include the display of dynamic scenes on web pages, the creation of dynamic backdrops for special effects and games, and the interactive control of video-based animation.
Identification of endogenous peptides recognized byin vivo orin vitro generated alloreactive cytotoxic T lymphocytes: distinct characteristics correlated with CD8 dependence (2001)

We studied the molecular basis for CD8 independence of in vivo generated (BM3.3) versus CD8 dependence of in vitro sensitized (KB5.C20/Des) alloreactive H-2K(b)-specific cytotoxic T lymphocytes (CTL). Using microcapillary high-performance liquid chromatography fractionation of H-2K(b) eluates, mass spectrometry and CTL reconstitution assays, we determined that BM3.3 and KB5.C20 recognize, respectively, a single peptide (pBM1) expressed on 8,000 H-2K(b) molecules per allogeneic cell, and three distinct peptides (pKB1, 2, 3), each expressed on around 200 H-2K(b) molecules per allogeneic cell. CD8 (in)dependence was intrinsic to the respective TCR/H-2K(b)-peptide interactions. KB5.C20 and BM3.3 TCR illustrate the correlation that appears to exist between CD8 dependence/low affinity and in vitro sensitization as opposed to low dependency on CD8 and high TCR affinity observed after in vivo sensitization. The results suggest that CD8-dependent alloreactive CTL obtained in vitro with high frequency correspond to low-affinity TCR from the MHC-biased TCR repertoire unpurged by negative selection and have implications for cellular immunotherapeutic approaches.
Effect of multidose drug dispensing on the time in therapeutic range in patients using vitamin‐K antagonists: A randomized controlled trial (2019)

The quality of anticoagulation can be improved with the use of MDD systems.
Highly-scalable 3D CLOS NOC for many-core CMPs (2010)

In order to accommodate hundreds of processing elements forming many-core chip multiprocessors (CMP), there is a growing need for easily scalable, high-performance and low-power interconnect infrastructure. In this paper, we propose using 3D integrated CLOS network-on-chip (CNOC) to achieve these goals. We present the design of a 512-node 3D CNOC and evaluate its power consumption. We compare the power consumption of 3D CNOC with a planar CNOC implementation and with 2D and 3D mesh topologies.
TCP revisited (2009)

Since the last in-depth studies of measured TCP traffic some 6-8 years ago, the Internet has experienced significant changes, including the rapid deployment of backbone links with 1-2 orders of magnitude more capacity, the emergence of bandwidth-intensive streaming applications, and the massive penetration of new TCP variants. These and other changes beg the question whether the characteristics of measured TCP traffic in today's Internet reflect these changes or have largely remained the same. To answer this question, we collected and analyzed packet traces from a number of Internet backbone and access links, focused on the "heavy-hitter" flows responsible for the majority of traffic. Next we analyzed their within-flow packet dynamics, and observed the following features: (1) in one of our datasets, up to 15.8% of flows have an initial congestion window (ICW) size larger than the upper bound specified by RFC 3390. (2) Among flows that encounter retransmission rates of more than 10%, 5% of them exhibit irregular retransmission behavior where the sender does not slow down its sending rate during retransmissions. (3) TCP flow clocking (i.e., regular spacing between flights of packets) can be caused by both RTT and non-RTT factors such as application or link layer, and 60% of flows studied show no pronounced flow clocking. To arrive at these findings, we developed novel techniques for analyzing unidirectional TCP flows, including a technique for inferring ICW size, a method for detecting irregular retransmissions, and a new approach for accurately extracting flow clocks.
Communication: Vacuum ultraviolet photoabsorption of interstellar icy thiols (2014)

Following the recent identification of ethanethiol in the interstellar medium (ISM) we have carried out Vacuum UltraViolet (VUV) spectroscopy studies of ethanethiol (CH3CH2SH) from 10 K until sublimation in an ultrahigh vacuum chamber simulating astrochemical conditions. These results are compared with those of methanethiol (CH3SH), the lower order thiol also reported to be present in the ISM. VUV spectra recorded at higher temperature reveal conformational changes in the ice and phase transitions whilst evidence for dimer production is also presented.
Energy management for commercial servers (2003)

Servers: high-end, multiprocessor systems running commercial workloads, have typically included extensive cooling systems and resided in custom-built rooms for high-power delivery. Recently, as transistor density and demand for computing resources have rapidly increased, even these high-end systems face energy-use constraints. Commercial-server energy management now focuses on conserving power in the memory and microprocessor subsystems. Because their workloads are typically structured as multiple application programs, system-wide approaches are more applicable to multiprocessor environments in commercial servers than techniques that primarily apply to single-application environments, such as those based on compiler optimizations.
C01 Effects of Stacking Method on Heat Transfer Characteristic in Stacked Wire Gauze (2nd Report) (2001)

The regenerator is the regenerative heat exchanger, which greatly influences the performance of the Stirling cycle machines. A stacked wire screen of which a balance of flow loss and heat transfer characteristics is good, is often utilized for this regenerator matrix. The stacking method of the wire gauze is a method for perpendicularly stacking for the flow of the working gas. Therefore, the basic characteristic of stacked wire gauze reported until now, was only perpendicular stacked wire gauze. However, the method stacking parallel to the flow of the working gas is also considered. In this study, in order to grasp the basic characteristics of parallel stacked wire gauze, the effect of the stacking method on basic characteristic is examined experimentally. The effect on the pressure loss examines experimentally in the previous report. So, the superiority of the parallel stack wire gauze has been confirmed. In this paper, the effect of the stacking method on Nusselt number is examined experimentally. And, the friction factor and Nusselt number of two type stacked wire gauze are compared.
Relationship between morphology and transparency in glass-ceramic materials (2018)

This paper is an attempt to understand and interpret optical scattering in composite materials. It focuses on phase-separated glasses and glass-ceramics that maintain transparency at high crystal content. Two approaches aimed at understanding optical scattering are investigated for each example material: (1) a single particle approach and (2) a correlation function approach based on the spatial distribution of the refractive index profile of the material pioneered by Debye. Both methods have shortcomings: the single particle approach cannot take the material’s morphology into account, and it is nontrivial to determine the correlation function. Regardless, the preferred approach is determined for each of the materials investigated. It is shown that optical scattering in glass-ceramics can be controlled to produce a transparent material if the glass-ceramic has a bulk fine-grained structure without an easily recognized “grain size.”
Blind Transmitted and Reflected Image Separation Using Depth Diversity and Time–of–Flight Sensors (2015)

We present a novel method for blind image source separation of transmitted and reflected images. Our approach exploits depth diversity and we repurpose Time–of–Flight (ToF) sensors to demix semi–reflective image mixtures.
Simultaneous reduction and covalent grafting of polythiophene on graphene oxide sheets for excellent capacitance retention (2016)

Herein, we report room temperature reduction and covalent grafting of GO sheets by thiophene derivatives to produce pseudocapacitive electrodes with high capacitance (230 F g<sup>−1</sup> at 1 mV s<sup>−1</sup>) and most important, 100% cycling retention after 5000 cycles.
Packaging challenges for small die (2012)

During the last few years, wafer technology has been shrinking aggressively from the 50nm node down to a much smaller technology node. This creates a disparity between die and packaging in which the die is miniaturizing, yet the packaging's physical footprint remains unchanged. Among the various packaging types, the one that is most impacted is board-on-chip (BOC) packaging, which is the current mainstream packaging for DDR2/DDR3 devices. The construction of the BOC package is a one-layer interposer with a window cut-out along the center; the die's active circuit faces down with respect to the package footprint. The interconnect between the die and package is wire, via the window cut-out. As the die shrinks, and the package footprint remains unchanged, one of the design bottlenecks is the trace fan-out issue from the bond finger to the innermost column of the ball, as well as the tighter bond finger pitch due to the die-pad pitch reduction. This paper will describe the design features that need be addressed for small-die packages - for example, the drive toward fine line trace, wire bond top pad width, and narrower bond slots. A test vehicle is tooled up as a simulation of possible manufacturing/process issues for the small-die package solution. The design and analysis of the experiment are described in full in this paper.
Proposal of Current Control Method for High-Speed AC Motor System (2008)

In this paper, current control method for High-Speed AC Motor System is proposed. In High-Speed driving operation, Current controller tends to lose stability because of dead time caused by computational delay and Electromagnetic coupling included AC Motor Model. The Main purpose of the proposed method is reduction of dead time on current controller. Proposed method based model predictive control and optimizing of start timing. The Effectiveness of proposed method is confirmed by simulation results.
64‐3: Invited Paper: High Optical Density Quantum Dot Pixel Color Conversion Films for Displays (2021)

Quantum Dot downconverters will enable high‐resolution, bright, and wide color gamut displays for all display formats. We have developed a method to directly photopattern densely packed InP/ZnS Quantum Dots that achieve an optical density of 2 at sub 10 µm thicknesses while preserving high photoluminescence quantum yield.
Cell‐Penetrating Peptides as Delivery Vehicles for a Protein‐Targeted Terbium Complex (2012)

Release after transmission: Arginine-rich, cell-penetrating peptides (CPPs) mediate cytoplasmic delivery of trimethoprim (TMP)-terbium complex conjugates and selective, intracellular labeling of E. coli dihydrofolate reductase (eDHFR) fusion proteins. A disulfide bond linking CPP and cargo is reduced following uptake. CPP conjugation can be used to deliver otherwise cell-impermeable, ligand-fluorophore conjugates.