gebhart/patrepeval huggingface dataset:
Conventional and functional assessment of spatial neglect: Clinical practice suggestions. (2018)

We showed that the CBS via KF-NAP was able: (a) to detect functional impairment, especially motor, related to SN; (b) to selectively measures spatial rather than nonspatial dysfunctions; and (c) to be highly sensitive in detecting SN signs especially in those patients with mild severity, covering several aspects of SN manifestations. The patient's SN diagnosis based on the CBS via KF-NAP is clinically important and directly relevant to care planning and goal setting. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
Mary Barber, “To the Rt. Hon. Charlotte Lady Conway, on her Resolving to Leave Bath” (2022)

Rupert Barber in Dublin and lived there from 1705 to 1724.She had nine children and began writing poetry to educate them.Barber's poems embody her social conscience.In 1724 she gained recognition for a collection of poems she sent to Lord and Lady Carteret, and this collection included a poem pleading the case of an army officer's widow and her blind son in need of charity.Her poetry also attracted the attention of Jonathan Swift, one of the foremost satirists in the English language.Swiftly famously became an outspoken advocate of her work, complimenting her poetic genius and manners to many of his contemporaries.As a result of their professional relationship, Barber
Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors (2016)

There are currently no treatments for life-threatening infections caused by human polyomaviruses JCV and BKV. We therefore report herein the first crystal structure of the hexameric helicase of JCV large T antigen (apo) and its use to drive the structure-based design of dual JCV and BKV ATP-competitive inhibitors. The crystal structures obtained by soaking our early inhibitors into the JCV helicase allowed us to rapidly improve the biochemical activity of our inhibitors from 18 μM for the early 6-(2-methoxyphenyl)- and the 6-(2-ethoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole hits 1a and 1b to 0.6 μM for triazolopyridine 12i. In addition, we were able to demonstrate measurable antiviral activity in Vero cells for our thiazolopyridine series in the absence of marked cytotoxicity, thus confirming the usefulness of this approach.
<title>Optical Interconnections In Microelectronics</title> (1984)

As the complexity of microelectronic circuits increases, performance becomes more and more limited by interconnections. Continued scaling and packing lead to a dominance of interconnect delays over gate delays. This paper explores the potential of optical inter-connections as a mean for alleviating such limitations. Various optical approaches to the problem are discussed, including the use of guided waves (integrated optics and fiber optics) and free space propagation (simple broadcast and imaging interconnections). The utility of optics is influenced by the nature of the algorithms that are being carried out in computations. Certain algorithms make far greater demands on interconnections than do others. Clock distribution is a specific application where optics can make an immediate contribution. Data interconnections are more demanding, and require the development of hybrid Si/GaAs devices and/or heteroepitaxial structures containing both Si and GaAs layers. The possibilities for future developments in this area are discussed.
Th17 cells target the metabolic miR-142-5p-SDHC/SDHD axis promoting invasiveness and progression of cervical cancers (2023)

Abstract During cervical carcinogenesis, T-helper (Th)-17 cells accumulate in the peripheral blood and tumor tissues of cancer patients. We previously demonstrated that Th17 cells are associated with therapy resistance as well as cervical cancer metastases and relapse, however, the underlying Th17-driven mechanisms supporting cervical cancer progression are not fully understood as yet. In this study, we found that Th17 cells promote migration and invasion of cervical cancer cells in 2D cultures and 3D spheroids. We demonstrated that Th17 cells induced the expression of miR-142-5p in cervical cancer cells supporting their migration and invasiveness. As the responsible mechanism, we identified the subunits C and D of the succinate dehydrogenase (SDH) complex as new targets of miR-142-5p and provided evidence that Th17 cells reduced the expression of SDHC and SDHD that was dependent on miR-142-5p. Functional downstream analysis with inhibitors of miR-142-5p and siRNA knock down of SDHC and SDHD revealed that Th17-induced miR-142-5p-mediated reduced expression of SDHC and SDHD was responsible for enhanced migration and invasion of cervical cancer cells. Consistently, cervical cancer patients exhibited high levels of succinate in their serum associated with lymph node metastases and diminished expression of SDHD in patients′ biopsies significantly correlated with increased numbers of Th17 cells, advanced tumor stage and lymph node metastases. Correspondingly, a combination of weak or negative SDHD expression and a ratio of Th17/CD4 + T cells &gt; 43.90 % in situ was associated with reduced recurrence free survival. In summary, we unraveled a novel molecular mechanism by which Th17 cells promote cervical cancer progression and suggest evaluation of Th17 cells as a potential target for immunotherapy in cervical cancer.
Q-methodology as a research and design tool for HCI (2013)

A "discount" version of Q-methodology for HCI, called "HCI-Q", can be used in iterative design cycles to explore, from the point of view of users and other stakeholders, what makes technologies personally significant. Initially, designers critically reflect on their own assumptions about how a design may affect social and individual behavior. Then, designers use these assumptions as stimuli to elicit other people's points of view. This process of critical self-reflection and evaluation helps the designer to assess the fit between a design and its intended social context of use. To demonstrate the utility of HCI-Q for research and design, we use HCI-Q to explore stakeholders' responses to a prototype Alternative and Augmentative Communication (AAC) application called Vid2Speech. We show that our adaptation of Q-methodology is useful for revealing the structure of consensus and conflict among stakeholder perspectives, helping to situate design within the context of relevant value tensions and norms.
Gene Expression Profiling Can Predict Responsiveness to Chemotherapy in Patients with Transformation of Follicular Lymphoma. (2006)

Abstract Background. Transformation to diffuse large cell lymphoma (DLCL) is a frequent event in patients with follicular lymphoma (FL), occurring in approximately 30–50% of patients. Upon transformation the prognosis of these patients is dismal, with a median overall survival of 1–2 years. However, a subset of patients does respond to aggressive chemotherapy regimens, including autologous stem cell transplantation and can achieve long-term disease-free survival. Currently, there are no prognostic factors reliably predicting response to treatment. We used gene expression profiling to identify a profile which can predict responsiveness to chemotherapy and long-term survival at transformation. Patients and methods. From the pathology archives of the 4 participating institutions, 46 cases with transformation of FL were identified for whom frozen tissue was available. 11 cases were excluded from the analysis: 4 because of insufficient clinical information and 7 because the patients were not treated with aggressive chemotherapy regimens (defined as containing at least CHOP-like chemotherapy). RNA was extracted from frozen tissue. All samples were hybridized to cDNA microarray slides prepared at the Central Microarray Facility at the Netherlands Cancer Institute. The arrays contain 18336 biological transcripts as well as 864 control probes. Samples were cohybridized with a tonsil reference. Data analysis was performed in the statistical package R as well as with BrB array tools. Results. Of the 35 patients, 62% was male. The median interval between the initial diagnosis of FL and transformation was 27 months (range 0–252; 4 patients had transformed FL at initial diagnosis). Median age at transformation was 52 years (range 32–78). Using hierarchical clustering, no clear separation of the cases was obtained. Of the 35 cases, 13 reached a CR or Cru and had an overall survival of &amp;gt;24 months (range 37–134+, median 60 months). 6 patients achieved a partial remission and had an overall survival of 12–24 months, and 16 patients had stable or progressive disease and died within 13 months (range 3–13, median 5.5 months). Using supervised analysis on patients grouped based on survival, a classifier with an accuracy of up to 88% accuracy could be reached in an LOOCV procedure. An analysis of the most differentially expressed genes related to survival identified mostly genes involved in cell cycle, metabolism and immune related genes. Conclusions. Using gene expression profiling a classifier can be constructed that can separate transformed FL with a long survival from transformed FL with a short survival. This classifier can help to identify patients who benefit from intensive chemotherapy. Functional annotation of the differentially expressed genes identified mostly genes involved in cell cycle control and metabolism, and immune related genes. We plan to validate this approach using immunohistochemistry.
Evaluate the Long-Term Efficacy and Patient Satisfaction Following Embolization of Pelvic Congestion (2023)

Introduction: Pelvic varices are frequent, could be found in 10% of women, and 40% of them may develop pelvic congestion syndrome. The IR treatment is known to be efficient but the approaches and methods are quite different between centers and doctors, mainly to prove the effectiveness of a sequential treatment.
Can Catheter Ablation in Cardiac Arrest Survivors Prevent Ventricular Fibrillation Recurrence? (1997)

Ventricular tachyarrhythmias are the most common cause for sudden cardiac death. The success of catheter ablation for supraventricular tachycardias led to the supposition that ablation could also be used in the treatment of ventricular tachycardias. Despite the promising results in bundle branch reentry and some forms of idiopathic ventricular tachycardia, the success rate in patients with coronary artery disease is still low. There is hope that new approaches to reliably localize the critical region of the tachycardia and new ablation techniques to create larger areas of injury may lead to a wider application of ablation therapy in the treatment of ventricular tachycardia. Survivors of cardiac arrest typically have more rapid and unstable arrhythmias than patients with sustained ventricular tachycardia, and these rapid arrhythmias frequently degenerate into ventricular fibrillation. The instability of the arrhythmia makes it impossible to localize the arrhythmia origin with current mapping techniques. Experimental and clinical data, however, suggest that these arrhythmias also frequently start from a localized area of electrical activation. With developments in mapping techniques and energy delivery, catheter ablation may soon become a feasible therapeutic approach in some patients with unstable arrhythmias. The article discusses the prerequisites for this approach and suggests the patients who may be appropriate candidates for this technique.
Design and performance of a multifiber backpanel type connector (1996)

A compact multifiber backpanel type connector has been constructed by applying backpanel housings to multifiber push-on (MPO) type plugs. Fabricated backpanel type connectors for 8-fiber ribbons exhibit a low insertion loss of 0.2 dB and a high return loss of 60 dB.
The responses of people tovirtual humans in an immersivevirtual environment (2005)

This paper presents an experiment investigating the impact of behavior and responsiveness
on social responses to virtual humans in an immersive virtual environment
(IVE). A number of responses are investigated, including presence, copresence, and
two physiological responses—heart rate and electrodermal activity (EDA). Our
findings suggest that increasing agents’ responsiveness even on a simple level can
have a significant impact on certain aspects of people’s social responses to humanoid
agents.
Despite being aware that the agents were computer-generated, participants with
higher levels of social anxiety were significantly more likely to avoid “disturbing”
them. This suggests that on some level people can respond to virtual humans as
social actors even in the absence of complex interaction.
Responses appear to be shaped both by the agents’ behaviors and by people’s expectations
of the technology. Participants experienced a significantly higher sense of
personal contact when the agents were visually responsive to them, as opposed to
static or simply moving. However, this effect diminished with experienced computer
users. Our preliminary analysis of objective heart-rate data reveals an identical pattern
of responses.
Mitigating the Trade-off between Triplet Harvesting and Roll-off by Opening a Dexter-Type Channel in OLEDs (2019)

As an approach to overcome the limitation of spin statistics in an electroluminescent (EL) system, the use of a sensitizing system, employing thermally activated delayed fluorescence (TADF) as an intermediate component or host, has been actively discussed recently. However, the existence of a nonradiative channel (i.e., Dexter energy transfer, DET) from the lowest triplet excited state (T1) in the TADF host or assistant layer still can cause the efficiency drop, although this strategy could break the spin multiplicity. In this context, an approach to break the limitation of the conventional sensitizing system on the basis of Förster resonance energy transfer (FRET) should be developed. Herein, we explore the potential of nonradiative energy loss, a DET-type channel, in shortening the triplet exciton residence time in an EL system, thereby achieving both improved efficiency and reduced roll-off. The discussions in the proposed triplet-harvest system raise the following points: (i) the necessity of an assistant dopant with high photoluminescence quantum yield, (ii) understanding of the key processes such as reverse intersystem crossing and the energy-transfer mechanism, and (iii) the role of exciton residence time in the presence of inefficient FRET in the sensitizing process.
The Role of Endoscopy in Managing Acute Lower Gastrointestinal Bleeding (2000)

In this issue of the Journal, Jensen et al. report their experience with the use of colonoscopy performed on an urgent basis for the diagnosis and treatment of acute hemorrhage from colonic diverticulosis.1 The study has two key messages. The first is that the endoscopic findings that characterize recent hemorrhage, routinely used in the evaluation of acute upper gastrointestinal bleeding, are also useful in establishing the diagnosis in a subgroup of patients with colonic diverticular hemorrhage. This group of findings, referred to as stigmata of recent hemorrhage, includes active bleeding (e.g., arterial spurting), nonbleeding visible vessels, appearing as discrete pigmented . . .
Short-wavelength (λ≈3.05μm) InP-based strain-compensated quantum-cascade laser (2007)

The design and implementation of a short-wavelength quantum-cascade laser based on the strain-compensated In0.73Ga0.27As–In0.55Al0.45As–AlAs heterosystem on InP is described. Lasers with a reduced level of doping in the active region require a larger bias voltage and emit at shorter wavelength; the emission wavelength is 3.05μm at T≈80K. The lasers operate up to T≈150K and electroluminescence persists up to room temperature, where the peak position is close to 3.3μm. The short-wavelength limit of such lasers is evaluated based on the dependence of their maximum operation temperatures and on the probable energies of the indirect valleys in the active region.
MONITORING IMMUNE RESPONSES IN CANCER PATIENTS RECEIVING TUMOR VACCINES (2003)

Clinical evaluation of therapeutic tumor vaccines has resulted in examination and comparison of the types of immune function assays required to monitor tumor antigen-stimulated T cell effector function in immunized patients. Three of the most commonly used assays include ELISPOT, tetramer assay, and cytokine flow cytometry (CFC). Discussed are the method and principles for each assay and an assessment of important methodological, reagent, and data acquisition issues that are relevant for the accurate and effective use of the assays. The sensitivity and utility of the assays and present arguments advocating their integrated use in future immunomonitoring studies are also discussed.
Fat Malabsorption Screening in Chronic Pancreatitis (2004)

To avoid nutritional deterioration, early screening for fat malabsorption should be recommended in chronic pancreatitis, whatever its etiology, using the acid steatocrit, a reliable, easy, and inexpensive test.
Interaction of different molecules with Cu2+ cations in CuH-ZSM-5. Electron spin resonance study and quantum-chemical calculations (1989)

An e.s.r. study of interaction between isolated coordinatively unsaturated Cu2+ cations located in dehydroxylated at 1073 K CuH-ZSM-5 and different molecules [NH3, pyridine, CH3OH, (CH3)2O, C3H6, p-xylene] has been carried out. The results obtained are compared with the data of INDO calculations. It is not only the possibility of coordinative complex formation in zeolite channels that must be taken into account when analysing the mechanism of Cu2+ interaction with sorbed molecules. A small change in donor–acceptor properties of Cu2+ ligand environment and a slight geometric displacement of Cu2+ ion in his chelate site may result in a noticeable change in hyperfine structure of the Cu2+ e.s.r. signal.
Gate reflectometry for probing charge and spin states in linear Si MOS split-gate arrays (2019)

We fabricated linear arrangements of multiple split-gate devices along an SOI mesa, thus forming a 2×N array of individually controllable Si quantum dots (QDs) with nearest neighbor coupling. We implemented two different gate reflectometry-based readout schemes to either probe spin-dependent charge movements by a coupled electrometer with single-shot precision, or directly sense a spin-dependent quantum capacitance. These results bear significance for fast, high-fidelity single-shot readout of large arrays of foundry-compatible Si MOS spin qubits.
New Synchrotron Radiation Center beamlines at Aladdin (1989)

In the past year, the Synchrotron Radiation Center (SRC) staff has installed five new beamlines at SRC. Three of these beamlines are ‘‘public’’ beamlines operated by SRC for experiments selected from peer-reviewed proposals. Fifty to seventy-five percent of the experimental time on the other two beamlines is managed by the SRC as a consequence of the SRC being a partner in participating research teams (PRTs). These new beamlines bring the number of VUV and soft x-ray research beamlines installed on Aladdin to 17 as of August 1988. Including two storage ring optical diagnostic ports, there will be 20 ports in use on Aladdin by the end of 1988.
Biochemical characterization of Lp_2777, a family 1 glycoside hydrolase from Lactoibacillus plantarum WCFS1 (2017)

Póster presentado a la VII International Conference on Environmental Industrial and Applied Microbiology, celebrada en Madrid (España) del 18 al 20 de octubre de 2017.
Enzymes in organic synthesis. 40. Evaluation of the enantioselectivity of the pig liver esterase catalyzed hydrolyses of racemic piperidine carboxylic acid esters (1987)

Pig liver esterase (PLE) catalyzed hydrolysis of racemic piperidine esters proceeds enantioselectively to give product acids and recovered esters in 0–47% enantiomeric excess.
Novel topological states in photonics (2014)

Certain novel, topologically non-trivial, photonic states will be presented. Their properties and potential applications will be discussed.
Automatic transcription of musical recordings (2001)

An automatic music transcription system is described which is applicable to the analysis of real-world musical recordings. Earlier presented algorithms are extended with two new methods. The first method suppresses the non-harmonic signal components caused by drums and percussive instruments by applying principles from RASTA spectrum processing. The second method estimates the number of concurrent voices by calculating certain acoustic features in the course of an iterative multipitch estimation system. Accompanying audio demonstrations are at
Re: Inhibition of Ca 2+ -Activated Cl - Channel ANO1/TMEM16A Expression Suppresses Tumor Growth and Invasiveness in Human Prostate Carcinoma (2013)

No AccessJournal of UrologyInvestigative Urology1 Jun 2013Re: Inhibition of Ca2+-Activated Cl- Channel ANO1/TMEM16A Expression Suppresses Tumor Growth and Invasiveness in Human Prostate Carcinoma Anthony AtalaM.D. Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.107AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Inhibition of Ca2+-Activated Cl- Channel ANO1/TMEM16A Expression Suppresses Tumor Growth and Invasiveness in Human Prostate Carcinoma." The Journal of Urology, 189(6), p. 2393 © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 6June 2013Page: 2393 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Finite Element Analysis of Whisker-Reinforced SiC/Al Composites Subjected to Cryogenic Temperature Thermal Cycling (1993)

Thermo-elastoplastic finite element methods are used to investigate the thermal cycling of SiC whisker-reinforced aluminum-matrix composites. In a previous investigation, the development of residual stresses and plastic deformation during cooling from a typical solution-treatment or annealing temperature to room temperature was studied. In the present paper we investigate changes in these residual quantities during thermal cycling, including cycling to cryogenic temperatures, and the effect of these changes on subsequent mechanical behavior. The effective coefficients of thermal expansion and convergence to a stable cyclic loop are also examined.