gebhart/patrepeval huggingface dataset:
Quality performance for indirect Xa inhibitor monitoring in patients using international external quality data (2020)

Objectives Chromogenic anti-activated factor X (FXa) assays are currently the "gold standard" for monitoring indirect anticoagulants. However, anti-FXa has been shown to vary according to the choice of reagents. In the present study, the performance of anti-FXa measurement was evaluated in order to gain more insight into the clinical applications. Furthermore, the longitudinal coefficient of variation (CV) was studied to investigate whether there is improvement over time. Methods Laboratory tests results were evaluated for samples spiked with unfractionated heparin (UFH), low-molecular-weight-heparin (LMWH), fondaparinux and danaparoid sodium. External quality assessment (EQA) data from multiple years were used from more than 100 laboratories. Results Comparison of the results for all methods showed significant differences in measured values between the frequently used methods (ANOVA: p < 0.001). The largest differences were observed for LMWH and UFH measurements. These differences may be caused by differences in method composition, such as the addition of dextran sulphate. Substantial interlaboratory variation in anti-FXa monitoring was observed for all parameters, particularly at low concentrations. Our results showed that below 0.35 IU/mL, the CVs for UFH and LMWH increase dramatically and results below this limit should be used with caution. Conclusions Our study demonstrates that the choice of the anti-FXa method is particularly important for UFH and LMWH measurement. The variation in measurements may have an effect on clinical implications, such as therapeutic ranges. Furthermore, the longitudinal EQA data demonstrated a constant performance and, in at least 50% of the cases, improvement in the CV% of the anti-Xa results over time.
ChemInform Abstract: CYCLOPENTANONE SYNTHESIS BY INTRAMOLECULAR CARBON‐HYDROGEN INSERTION OF DIAZO KETONES. A DITERPENE‐TO‐STEROID SKELETON CONVERSION (1983)

Abstract Aus den 1‐Methyl‐cycloalkancarbonsäuren (II) werden die Diazoketone (III) hergestellt, deren Thermolyse in Gegenwart von Cu‐Salzen überwiegend zu den Cyclopentanonen (IV) neben den Cyclobutanonen (V) führt; (IIa) wird aus (Ia) über (Ib) und (Ic) hergestellt.
Comparative evaluation of electron-beam sensitive single layer top surface imaging and bilayer chemical amplification of resist lines process for stencil mask making (1999)

Hardmask-less stencil mask making requires resist masks with a high aspect ratio. Single layer top surface imaging (TSI) and bilayer chemical amplification of resist lines (CARL) were evaluated and compared, with respect of generating irregular resist features below 180 nm in a film thickness of 850 nm. Special methods for eliminating the resolution-limiting effect of the glass transition temperature (Tg) drop are described. Optimized plasma etching conditions for both thin layer imaging (TLI) techniques were developed. Finally, results of a deep silicon etching process using the TLI resist masks are presented.
Validation of a Scoliometer Smartphone App to Assess Scoliosis (2012)

Validation of this new device demonstrates the potential to increase the distribution of cost-effective scoliosis screening tools to a broad population of medical providers.
Highly Regioselective Synthesis of 1-Aryl-3,4,5-Substituted Pyrazoles (2006)

A highly regioselective synthesis of 1-aryl-3,4,5-substituted pyrazoles based on the condensation of 1,3-diketones with arylhydrazines is described. The reaction proceeds at room temperature in N,N-dimethylacetamide and furnishes pyrazoles in 59-98% yields.
Listen and Whisper: Security Mechanisms for BGP (Awarded Best Student Paper!). (2004)

The prototype willingness model (PWM) was designed to extend expectancy-value models of health behaviour by also including a heuristic, or social reactive pathway, to better explain health-risk behaviours in adolescents and young adults. The pathway includes prototype, i.e., images of a typical person who engages in a behaviour, and willingness to engage in behaviour. The current study describes a meta-analysis of predictive research using the PWM and explores the role of the heuristic pathway and intentions in predicting behaviour. Eighty-one studies met inclusion criteria. Overall, the PWM was supported and explained 20.5% of the variance in behaviour. Willingness explained 4.9% of the variance in behaviour over and above intention, although intention tended to be more strongly related to behaviour than was willingness. The strength of the PWM relationships tended to vary according to the behaviour being tested, with alcohol consumption being the behaviour best explained. Age was also an important moderator, and, as expected, PWM behaviour was best accounted for within adolescent samples. Results were heterogeneous even after moderators were taken into consideration. This meta-analysis provides support for the PWM and may be used to inform future interventions that can be tailored for at-risk populations.
Quantitative Cardiac Output Assessment Using 4D Ultrafast Doppler Imaging: An in Vitro Study (2018)

Background, Motivation and Objective Echocardiography is routinely used in the clinic to evaluate the cardiac function. Anatomical indexes such as ventricular volume measurements or functional indexes such Cardiac Output are performed using standard echocardiography. However, 2D dimensional measurements induce inter-operator variability and standard 3D measurements do not have the sufficient volume rate to evaluate functional indexes. Moreover, the accuracy of flow velocity estimates is strongly reduced by the angular dependence of Doppler measurements. In this study, we propose to use 4D ultrafast Doppler to evaluate flow rates in a pipe to demonstrate the potentiality of performing Cardiac Output measurements without assumptions on the valve geometry and without angular dependence. Statement of Contribution/Methods An ultrasonic matrix array probe (central frequency 2.5MHz, 1024 elements, pitch 0.3 mm, bandwith 60%, Vermon, France) connected to a 1024 channels ultrasound scanner prototype was used to image the pipe output in three dimensions. 500 diverging waves (angular aperture 80°) were emitted at a volume rate of 2000 volumes/s during 250 ms. Color Doppler volumes (quantitative flow speed volumes) were computed by calculating the first moment of the Doppler spectrums in each voxel. The pipe flow rates (N=7) were calculated by integrating directly the flow speed over the cross section of the pipe. Results/Discussion The measured flow rates were found to be in a good agreement with the flowmeter values used as a gold standard (R2 = 0.96). The four dimensional nature of the acquisition has the potential to enable the calculation of the Cardiac Output in vivo in patients without the need of making any assumption on the valve geometry or the direction of the ultrasonic beam usually responsible for errors.
Ultra-low Nonlinearity EDFAs Employing Multi-Mode EDF with Effective Mode Area of 81µm2 (2004)

Employing the large Aeff EDFs that can maintain the single-mode operation, the four-wave-mixing cross-talk over L-band has been suppressed by 10dB compared with the conventional EDFs when the output signal power is set to +28dBm.
MP32-17 PELVIC PAIN FROM INFLATABLE PENILE PROSTHESIS IMPLANTATION PERSISTS AFTER REVISION OR EXPLANTATION (2018)

You have accessJournal of UrologySexual Function/Dysfunction: Surgical Therapy II1 Apr 2018MP32-17 PELVIC PAIN FROM INFLATABLE PENILE PROSTHESIS IMPLANTATION PERSISTS AFTER REVISION OR EXPLANTATION Jeffrey D Campbell, Emad Rajih, and Arthur L Burnett Jeffrey D CampbellJeffrey D Campbell More articles by this author , Emad RajihEmad Rajih More articles by this author , and Arthur L BurnettArthur L Burnett More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.1067AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Inflatable penile prosthesis (IPP) implantation represents an important treatment for erectile dysfunction (ED) that is considered when medical therapy is contraindicated, unsuccessful, or undesirable. New chronic pelvic pain after IPP implantation is an important complication that is rarely discussed in the prosthesis literature, and the treatment of this phenomenon is unclear. We aim to evaluate whether revision IPP surgery for the treatment of chronic pain improves patients' symptomatology, or paradoxically exacerbates their conditions. METHODS Retrospective analysis of 198 patients who had an IPP revision or explant at a single center between May 2006 and March 2017. We included patients who developed chronic pelvic pain after IPP implantation and underwent a revision surgery or IPP explantation for symptomatic relief. We excluded patients who did not have pain for at least 3 months, patients who had pain associated with infection or erosion, and in whom we did not have long-term follow-up data. Persistent pain after surgery was based on patient self-report. RESULTS A total of 22 patients who met our criteria underwent surgical revision (n = 17) or IPP explantation (n = 5). Fifteen (68%) patients had persistent pelvic pain despite surgical intervention. Only patients who had pain secondary to a malpositioned device improved after revision. A prior diagnosis of a chronic pain syndrome was associated with persistent pain after intervention. Pain improvement was not associated with age, comorbid conditions, smoking status, duration of implant, cause of ED, or the number of surgical revisions performed. CONCLUSIONS Surgical revision for new pelvic pain after IPP implantation is unlikely to relieve patient symptoms unless the device is situated in an improper location. Patients need to be counselled that surgical procedures as a treatment for pain should be avoided and consideration of alternative therapeutic options may be more beneficial. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e426 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Jeffrey D Campbell More articles by this author Emad Rajih More articles by this author Arthur L Burnett More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Photoacoustic Spectrometer with a Calculable Cell Constant for Measurements of Gases and Aerosols (2010)

We benchmark the performance of a photoacoustic spectrometer with a calculable cell constant in applications related to climate change measurements. As presently implemented, this spectrometer has a detection limit of 3.1 × 10(-9) W cm(-1) Hz(-1/2) for absorption by a gas and 1.5 × 10(-8) W cm(-1) Hz(-1/2) for soot particles. Nonstatistical uncertainty limited the accuracy of the instrument to ∼1%, and measurements of the concentration of CO(2) in laboratory air agreed with measurements made using a cavity ring-down spectrometer, to within 1%. Measurements of the enhanced absorption resulting from ultrathin (<5 nm), nonabsorbing coatings on nanoscale soot particles demonstrate the sensitivity of this instrument. Together, these measurements show the instrument's ability to quantitatively measure the absorption coefficient for species of interest to the climate and atmospheric science communities. Because the system constant is known, in most applications the acoustic response of this instrument need not be calibrated against a sample of known optical density, a decided advantage in field applications. Routine enhancements, such as improved processing of the photoacoustic signal and higher laser beam power, should further increase the instrument's precision and sensitivity.
Robotic assembly in a free-floating work environment (2002)

Freely moving systems in space conserve linear and angular momentum. As moving systems collide, the velocities get altered due to transfer of momentum. The development of strategies for assembly in a free-floating work environment requires a good understanding of primitives such as self motion of the robot, propulsion of the robot due to onboard thrusters, docking of the robot, retrieval of an object from a collection of objects, and release of an object in an object pool. The analytics of such assemblies involve not only kinematics and rigid body dynamics but also collision and impact dynamics of multibody systems. This paper presents analytical models of assembly primitives and strategies for overall assembly.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Abstract P1-10-16: Cardiac conduction system exposure with modern radiotherapy techniques for breast cancer irradiation (2023)

Abstract Introduction: Exposition of cardiac conduction system during breast radiotherapy has never been studied, despite increasing use of intensity modulated radiotherapy which expose larger volume to low dose bath. We evaluated conduction node exposure during breast irradiation with volumetric modulated arctherapy (VMAT) and estimated the potential dosimetric benefit with intensity modulated protontherapy (IMPT). Materials and methods: Atrioventricular (AVN) and sinoatrial (SAN) nodes were retrospectively delineated according to published guidelines on the simulation CT scans of twelve breast cancer patients having undergone conserving surgery and adjuvant locoregional VMAT. IMPT treatment was re-planned on the simulation CT scans for all breast cancer patients. Mean and maximum doses to the SAN and the AVN were retrieved and compared. Correlation coefficients were calculated between doses to the SAN or the AVN and to the whole heart. Results: Average mean doses to the SAN and to the AVN were 2.8 Gy and 2.3 Gy respectively for left-sided irradiation and 9.6 Gy and 3.6 Gy respectively for right-sided irradiation. Average maximum doses to the SAN and to the AVN were 3.5 Gy and 2.8 Gy respectively for left-sided irradiation and 13.1 Gy and 4.6 Gy respectively for right-sided irradiation. IMPT significantly reduces doses to conduction nodes. Correlations between doses to the SAN or the AVN and the whole heart were usually significant. Conclusion: SAN and AVN can be substantially exposed during breast VMAT, especially for right-sided irradiation. Cardiotoxicity studies evaluating conduction node exposure might define dose constraints and criteria for additional cardiac sparing techniques, such as respiratory techniques or proton therapy, which could be beneficial to patients with underlying rhythmic or conduction disorders. Citation Format: Pierre Loap, Farid Goudjil, Ludovic De Marzi, Vincent Servois, Krassen Kirov, Alain Fourquet, Youlia M. Kirova. Cardiac conduction system exposure with modern radiotherapy techniques for breast cancer irradiation [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P1-10-16.
Measurement of photon–jet transverse momentum correlations in 5.02 TeV Pb + Pb and pp collisions with ATLAS (2018)

Jets created in association with a photon can be used as a calibrated probe to study energy loss in the medium created in nuclear collisions. Measurements of the transverse momentum balance between isolated photons and inclusive jets are presented using integrated luminosities of 0.49 nb -1 of Pb + Pb collision data at s NN = 5.02 TeV and 25 pb -1 of pp collision data at s = 5.02 TeV recorded with the ATLAS detector at the LHC. Photons with transverse momentum 63.1 < p T < 200 GeV and < 2.37 are paired with all jets in the event that have p jet T > 31.6 GeV and pseudorapidity jet < 2.8. The transverse momentum balance given by the jet-to-photon p T ratio, x J , is measured for pairs with azimuthal opening angle > 7 /8. Distributions of the per-photon jet yield as a function of x J , (1/N )(dN/dx J ), are corrected for detector effects via a two-dimensional unfolding procedure and reported at the particle level. In pp collisions, the distributions are well described by Monte Carlo event generators. In Pb + Pb collisions, the x J distribution is modified from that observed in pp collisions with increasing centrality, consistent with the picture of parton energy loss in the hot nuclear medium. The data are compared with a suite of energy-loss models and calculations.
The Chromosome Region for Immunoglobulin Heavy Chains in the Mouse: Allelic Electrophoretic Mobility Differences and Allotype Suppression (1967)

It is only about three years since it was first recognized explicitly that there are separate genes for the various immunoglobulin heavy chains that distinguish the heavy chain classes. At the 1964 Cold Spring Harbor meeting, evidence for the close linkage of these genes was presented for man (Kunkel et al., 1964) and the mouse (Herzenberg, 1964). We then reported that the two genes for a γG-globulin and γA-globulin marked by allelic antigenic differences or allotypes did not recombine in 78 backcross animals tested, indicating quite close linkage. Further, on examining the alleles for the two loci in some 80 inbred strains of mice we found a complete association between γA and γG alleles except in a few cases where there was too little serum γA to detect the allotype by the relatively less sensitive Ouchterlony test then being used. When we employed the more sensitive inhibition of I125 labeled...
Subcellular Locations of Phosphatidylinositol 4-Kinase Isoforms (1997)

Phosphatidylinositol (PtdIns) 4-kinase catalyzes the synthesis of PtdIns-4-P, the precursor of an array of lipid second messengers generated by additional phosphorylation by PtdIns-4-P 5-kinase and PtdIns 3-kinase. PtdIns 4-kinase activity is conserved from yeast to higher eukaryotes. Multiple isoforms of mammalian PtdIns 4-kinase have been purified, and the activities have been detected in almost all subcellular locations. We previously reported the cloning and characterization of the first mammalian PtdIns 4-kinase named PI4Kalpha (Wong, K., and Cantley, L. C. (1994) J. Biol. Chem. 269, 28878-28884). Alternatively spliced forms of PI4Kalpha have also been identified from several sources including bovine brain (Gehrmann, T., Vereb, G., Schmidt, M., Klix, D., Meyer, H. E., Varsanyi, M., and Heilmeyer, L. M., Jr. (1996) Biochim. Biophys. Acta 1311, 53-63). Recently we isolated a distinct human PtdIns 4-kinase gene, named PI4Kbeta, that encodes an enzyme that is wortmannin sensitive (Meyers, R., and Cantley, L. C. (1997) J. Biol. Chem. 272, 4384-4390). Here we report the locations of these enzymes and provide evidence for other yet unidentified isoforms present in specific organelles. PI4Kalpha is mostly membrane-bound and located at the endoplasmic reticulum; whereas PI4Kbeta is in the cytosol and also present in the Golgi region. Neither of these isoforms accounts for the major type II PtdIns 4-kinase activity detected in the lysosomes and plasma membrane fraction.
Accelerating the Translation of Nanomaterials in Biomedicine (2020)

Due to their size and tailorable physicochemical properties, nanomaterials are an emerging class of structures utilized in biomedical applications. There are now many prominent examples of nanomaterials being used to improve human health, in areas ranging from imaging and diagnostics to therapeutics and regenerative medicine. An overview of these examples reveals several common areas of synergy and future challenges. This Nano Focus discusses the current status and future potential of promising nanomaterials and their translation from the laboratory to the clinic, by highlighting a handful of successful examples.
NKp30 and its ligands: emerging players in tumor immune evasion from natural killer cells. (2015)

It is indisputable that natural killer (NK) immune surveillance is of crucial importance for hematological and solid tumors. However, the outcome of NK cell-based immune therapies appears disappointing in many trials. Limitations include poor in vivo survival or lack of specificity and are often attributed to tumor-associated immune escape mechanisms. NK cells are terminally activated by ligation of the activating NK receptors NKG2D, NKp30 or NKp46 through their corresponding ligands, which are up-regulated on the cell surface of dangerous cells (1-5). There is evidence that malignant cells bypass the NK surveillance by releasing these ligands as soluble proteins, as shown for NKG2D and NKp30 ligands (6-10). In most cases, the ligands are released by metalloproteinase-dependent shedding. The relevance of this mechanism was clearly confirmed in a transgenic animal model, showing spontaneous growth of tumors with the shedding-proficient NKG2D ligand MICA but tumor-free survival of animals with a shedding-resistant NKG2D ligand (11).
Cooperative application of holography and finite element modeling in determining critical vibration behavior of printed wiring boards (2002)

A PWB (printed wiring board) with dimensions of 6.5"/spl times/5.5" and attached with several bolts along the perimeter as constraints was acoustically vibrated and studied using CAH (computer-aided holometry). The frequency and shape of the first (primary) and second resonant modes, revealing the full field displacements and strains of the PWBs, were recorded automatically. Zero-displacement regions were also recorded for possible locations of strategic components. Finite element (FE) modeling using eigenvalue calculations was applied to correlate with the CAH results. Adjusting the boundary conditions in the modeling effort so as to match the experimental results proved to be the tricky task in the FE analysis since the mode shapes were extremely sensitive to boundary constraints.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Correction: Corrigendum: 3D printed cellular solid outperforms traditional stochastic foam in long-term mechanical response (2016)

Scientific Reports 6: Article number: 24871; Published online: 27 April 2016; Updated 25 May 2016 The Acknowledgements section in this Article is incomplete. “We would like to sincerely thank Dr. Jim Schneider of National Security Campus, MO (formerly Kansas City Plant) for giving us access to the results of their load retention study on the stochastic foam material.
Tumor imaging with a radiofluorinated divalent knottin (2014)

1084 Objectives A divalent knottin 3-4A containing two separate integrin binding epitopes (RGD) in the adjacent loops was recently discovered in our previous report.Here,3-4A was radiofluorinated with a 18F-fluoropropionate (NFP) group,and was evaluated as a novel imaging probe to detect integrin αvβ3 positive tumors in living animals. Methods Knottin 3-4A was synthesized by solid phase peptide synthesis,folded and site-specifically conjugated with 4-nitrophenyl 2-18/19F-NFP to produce the fluorinated peptide 18/19F-FP-3-4A.The stability of 18F-FP-3-4A was tested in PBS buffer and mouse serum.Cell uptake assay was performed using U87MG cell lines.microPET imaging and biodistribution studies were performed in U87MG tumor-bearing mice. Results 18F-FP-3-4A exhibited excellent stability in PBS buffer and mouse serum.microPET imaging and biodistribution data revealed that 18F-FP-3-4A exhibited rapid and good tumor uptake (3.76±0.59%ID/g at 0.5h),and rapidly clear from normal tissues(liver:0.68±0.12%ID/g at 0.5h),resulting in excellent tumor-to-normal tissue contrasts.Moreover,co-injection of 18F-FP-3-4A with c(RGDyK) significantly inhibited tumor uptake,demonstrating binding specificity. Conclusions 18F-FP-3-4A is characterized by rapid and high tumor uptake,and excellent tumor-to-normal tissue ratios. It is a highly promising knottin based PET probe for translating into clinical imaging of tumor angiogenesis. Research Support Office of Science (BER), U.S. Department of Energy (DE-SC0008397), NCI In Vivo Cellular Molecular Imaging Center (ICMIC) grant P50 CA114747, National Science Foundation for Young Scholars of China (Grant No. 81101072).