gebhart/patrepeval huggingface dataset:
Spiro[pyrrolidine-3,3′-oxindoles] and Their Indoline Analogues as New 5-HT6 Receptor Chemotypes (2017)

Synthetic derivatives of spiro[pyrrolidinyl-3,3'-oxindole] alkaloids (coerulescine analogues) were investigated as new ligands for aminergic G-protein coupled receptors (GPCRs). The chemical starting point 2'-phenylspiro[indoline-3,3'-pyrrolidin]-2-one scaffold was identified by virtual fragment screening utilizing ligand- and structure based methods. As a part of the hit-to-lead optimization a structure-activity relationship analysis was performed to explore the differently substituted 2'-phenyl-derivatives, introducing the phenylsulphonyl pharmacophore and examining the corresponding reduced spiro[pyrrolidine-3,3'-indoline] scaffold. The optimization process led to ligands with submicromolar affinities towards the 5-HT₆ receptor that might serve as viable leads for further optimization.
Development of Photoactive Sweet-C 60 for Pancreatic Cancer Stellate Cell Therapy (2018)

Obtained glycoconjugated nanoplatform is a promising nanotherapeutic for pancreatic cancer.
Design of an integrated propane fuel reformer and fuel cell system for unmanned aerial system (UAS) applications (2016)

Recent fuel cell research has focused on systems for passenger vehicles, commercial buildings, and small handheld devices. These applications typically require power outputs that are either greater than 100 kW or less than 20 W, and a gap remains in developing viable fuel cell systems for applications requiring between 100 W and 100 kW. An integrated reformer fuel cell system has been developed for these medium power applications that utilizes a propane catalytic partial oxidation reformer coupled with a polybenzimidazole-based high-temperature proton exchange membrane fuel cell. After investigation into the requirements of military unmanned aerial systems (UASs), a system was designed to produce a net power of 250 W with a total mass of 2.23 kg and potential for 200-hour lifetime. The proposed design offers advantages over current UAS propulsion technologies because it is both quiet and capable of long duration flights, and also has advantages over other fuel cell systems as it is fueled with commonly available propane instead of high purity hydrogen.
The Progression of Patellofemoral Arthrosis after Medial Unicompartmental Replacement (2004)

This study reports the 11-year to 15-year results of unicompartmental knee arthroplasty with an emphasis on failure mechanisms and progression of patellofemoral arthrosis. In a prospective study of 513 consecutive potential knee replacement candidates, 59 patients (12%) had medial unicompartmental arthroplasty of the knee. All 59 patients had isolated unicompartmental disease without clinical symptoms or radiographic evidence of patellofemoral arthritis. No patient was lost to followup. The average followup was 13 years (range, 11-15 years). The mean preoperative Hospital for Special Surgery knee score of 55 points (range, 30-79 points) improved to a mean of 90 points (range, 60-100 points) at final followup. Patellofemoral symptoms were present in 1.6% of patients at 10 years; this increased markedly to 10% of patients at 15 years (p < 0.01). Four patients (10%) had moderate or severe patellofemoral symptoms at final followup; two were revised to a primary total knee replacement at 7 and 11 years for progressive patellofemoral degeneration. No component was radiographically loose and no osteolysis was seen. The Kaplan-Meier survival with loosening or revision for any reason was 98.0% +/- 2.0% at 10 years and 95.7% +/- 4.3% at 15 years. At up to 15 years, unicompartmental knee arthroplasty yielded good clinical results; however, progressive patellofemoral arthritis was the primary mode of failure.
Superconducting magnet program for X-ray lithography source at Brookhaven National Laboratory (2002)

Brookhaven National Laboratory is developing a compact electron storage ring to be used as an X-ray source for producing high-density computer chips. The circumference of this machine is 8.5 m, the machine lattice consists of four quadrupoles, two sectupoles, and a pair of air-core combined function 3.87 T superconducting dipoles. The authors describe the field characteristics and engineering realization of these magnets and present the current status of the program.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
OmniKinect (2012)

Real-time three-dimensional acquisition of real-world scenes has many important applications in computer graphics, computer vision and human-computer interaction. Inexpensive depth sensors such as the Microsoft Kinect allow to leverage the development of such applications. However, this technology is still relatively recent, and no detailed studies on its scalability to dense and view-independent acquisition have been reported. This paper addresses the question of what can be done with a larger number of Kinects used simultaneously. We describe an interference-reducing physical setup, a calibration procedure and an extension to the KinectFusion algorithm, which allows to produce high quality volumetric reconstructions from multiple Kinects whilst overcoming systematic errors in the depth measurements. We also report on enhancing image based visual hull rendering by depth measurements, and compare the results to KinectFusion. Our system provides practical insight into achievable spatial and radial range and into bandwidth requirements for depth data acquisition. Finally, we present a number of practical applications of our system.
Design and Synthesis of Foldamers Based on an Anthracene Diels–Alder Adduct (2001)

A twelve-membered hydrogen-bonded ring and the resulting helical structure (see picture) in the tetrapeptide and an eight-membered hydrogen-bonded ring in the dipeptide illustrate the structural consequences of the incorporation of the novel β-amino acid derived from the Diels–Alder adduct of anthracene and dimenthyl fumarate.
Trust as dependence: a logical approach (2011)

We propose that the trust an agent places in another agent declaratively captures an architectural connector between the two agents. We formulate trust as a generic modality expressing a relationship between a truster and a trustee. Specifically, trust here is definitionally independent of, albeit constrained by, other relevant modalities such as commitments and beliefs. Trust applies to a variety of attributes of the relationship between truster and trustee. For example, an agent may trust someone to possess an important capability, exercise good judgment, or to intend to help it. Although such varieties of trust are hugely different, they respect common logical patterns. We present a logic of trust that expresses such patterns as reasoning postulates concerning the static representation of trust, its dynamics, and its relationships with teamwork and other agent interactions. In this manner, the proposed logic illustrates the general properties of trust that reflect natural intuitions, and can facilitate the engineering of multiagent systems.
Applications of Menthol in Synthetic Chemistry (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Resolution Limits of Timing-Based Servo Schemes in Magnetic Tape Drives (2015)

The resolution limits of tape head lateral position estimates derived from timing-based servo (TBS) patterns preformatted on perpendicularly oriented barium ferrite tape media are investigated. A set of four new TBS patterns with azimuth angles ranging from 15° to 24° but having, otherwise, identical parameters are compared. Measurements of the standard deviation of the closed-loop position-error signal are compared with resolution estimates based on: 1) the noise floor of the power spectral density of the lateral tape motion measured from the servo pattern during open or closed-loop track-following and 2) an analytical lower bound on the mean-squared estimation error, which depends on the servo readback signal shape and the signal-to-noise ratio. All four servo patterns are shown to achieve nanoscale resolution under realistic operating conditions. The 24° pattern was found to provide the highest performance with a position estimation resolution better than 3.8 nm for a single channel, and better than 2.6 nm when the estimates of two channels are combined.
Statistical Variance in Switching Probability of Spin-Torque Switching in MgO-MTJ (2012)

Statistical variance in the switching probability of spin-torque switching was studied on conventional in-plane MgO-MTJs. Spin-torque switching events by a current pulse longer than inverse of the attempt frequency (typically ~ 1 nsec) are well described by the thermal activation model. This model provides the relationship between the switching probability and the current amplitude. If the switching probability is unchanged for a large number of switching events, the statistical variance in the switching probability can be obtained analytically. However, we found the statistical variance in the switching probability varies widely on measured in-plane type CoFeB/MgO/CoFeB-MTJs. Contrary to a simple expectation, the slightly negative correlation was observed between the thermal stability parameter Δ and the statistical variance in the switching probability. We also measured the external magnetic field dependence along the easy axis, and found that the external field which assists the spin-torque switching dramatically increases the statistical variance of the switching probability. This behavior is considered one of the evidence of the effect of sub-volume excitation.
The Learned Inexact Project Gradient Descent Algorithm (2018)

Accelerating iterative algorithms for solving inverse problems using neural networks have become a very popular strategy in the recent years. In this work, we propose a theoretical analysis that may provide an explanation for its success. Our theory relies on the usage of inexact projections with the projected gradient descent (PGD) method. It is demonstrated in various problems including image super-resolution.
Long Coherence Length 193 nm Laser for High-Resolution Nano-Fabrication (2008)

Abstract : Immersion lithography using available 193 nm optics and laser sources provides an attractive near-term path to reducing the printable feature sizes of integrated circuits by using a high-index fluid to reduce the wavelength at the wafer, rather than using light with higher photon energy and shorter vacuum wavelength. An interferometric immersion lithography (IIL) tool has demonstrated rapid fabrication of grating structures with half-pitches of 35 nm over exposure areas of 0.5 mm. This Phase I project has resulted in the design of a high power, sub-200 nm solid-state light source with very high spatial -- and temporal -- coherence to allow uniform high-contrast intensity fringes (<30 nm HP) to illuminate a wafer surface over a substantially larger exposure area, on the order of a 22 x 33 nun exposure site. In addition, the laser will have high power stability and be sufficiently robust to allow extended periods of operation with little maintenance or operator intervention.
Supplementary Figure 2 from Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors (2023)

Supplementary Figure 2 from Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors
Noninvasive fibrosis marker can predict recurrence of hepatocellular carcinoma after radiofrequency ablation (2016)

These findings show that a high APRI value is associated with HCC recurrence after RFA. Therefore, APRI could play an important role in predicting HCC recurrence after RFA.
Visual homing with a pan-tilt based stereo camera (2013)

Visual homing is a navigation method based on comparing a stored image of the goal location and the current image (current view) to determine how to navigate to the goal location.It is theorized that insects, such as ants and bees, employ visual homing methods to return to their nest [1].Visual homing has been applied to autonomous robot platforms using two main approaches: holistic and feature-based.Both methods aim at determining distance and direction to the goal location.Navigational algorithms using Scale Invariant Feature Transforms (SIFT) have gained great popularity in the recent years due to the robustness of the feature operator.Churchill and Vardy [2] have developed a visual homing method using scale change information (Homing in Scale Space, HiSS) from SIFT.HiSS uses SIFT feature scale change information to determine distance between the robot and the goal location.Since the scale component is discrete with a small range of values [3], the result is a rough measurement with limited accuracy.We have developed a method that uses stereo data, resulting in better homing performance.Our approach utilizes a pantilt based stereo camera, which is used to build composite wide-field images.We use the wide-field images combined with stereo-data obtained from the stereo camera to extend the keypoint vector described in [3] to include a new parameter, depth (z).Using this info, our algorithm determines the distance and orientation from the robot to the goal location.We compare our method with HiSS in a set of indoor trials using a Pioneer 3-AT robot equipped with a BumbleBee2 stereo camera.We evaluate the performance of both methods using a set of performance measures described in this paper.
Quantitative analysis of the coupling between proton and electron transport in peptide/manganese oxide hybrid films (2020)

Understanding how electrons and protons move in a coupled manner and affect one another is important to the design of proton-electron conductors and achieving biological transport in synthetic materials. In this study, a new methodology is proposed that allows for the quantification of the degree of coupling between electrons and protons in tyrosine-rich peptides and metal oxide hybrid films at room temperature under a voltage bias. This approach is developed according to the Onsager principle, which has been thoroughly established for the investigation of mixed ion-electron conductors with electron and oxide ion vacancies as carriers at high temperatures. Herein, a new device platform using electron-blocking electrodes provides a new strategy to investigate the coupling of protons and electrons in bulk materials beyond the molecular level investigation of coupled proton and electron transfer. Two Onsager transport parameters, α<sub>i</sub>* and σ<sub>e</sub>', are obtained from the device, and the results of these transport parameters demonstrate that the coupled transport of electrons and protons inside the hybrid film plays an important role in the macroscopic-scale conduction. The results suggest that an average of one electron is dragged by one proton in the absence of a direct driving force for electron movement ∇η<sub>e</sub>.
Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing (2022)

3,3-Disubstituted oxetanes have been utilized as bioisosteres for gem-dimethyl and cyclobutane functionalities. We report the discovery of a novel class of oxetane indole-amine 2,3-dioxygenase (IDO1) inhibitors suitable for Q3W (once every 3 weeks) oral and parenteral dosing. A diamide class of IDO inhibitors was discovered through an automated ligand identification system (ALIS). Installation of an oxetane and fluorophenyl dramatically improved the potency. Identification of a biaryl moiety as an unconventional amide isostere addressed the metabolic liability of amide hydrolysis. Metabolism identification (Met-ID)-guided target design and the introduction of polarity resulted in the discovery of potent IDO inhibitors with excellent pharmacokinetic (PK) profiles in multiple species. To enable rapid synthesis of the key oxetane intermediate, a novel oxetane ring cyclization was also developed, as well as optimization of a literature route on kg scale. These IDO inhibitors may enable unambiguous proof-of-concept testing for the IDO1 inhibition mechanism for oncology.
Inter system EMC tests on Indian Light Combat Aircraft (2003)

System level EMI/EMC tests were carried out on the Indian Light Combat Aircraft (LCA) prior to its maiden flight. This paper discusses the various aspects of testing, execution and performance of the system level EMI/EMC tests on LCA.
Gold colloids in sol-gel-derived SiO 2 coatings on glass and their linear and nonlinear optical properties (1994)

An organic-inorganic synthesis route to Au-colloid containing, transparent SiO<SUB>2</SUB> coatings has been developed, using four different types of functionalized silanes as stabilizing ligands for the Au. By variation of the kind and the concentration of the stabilizing silane in the sol the onset temperature for the colloid formation varies between 100 and 300 degree(s)C and the final colloid radii can be controlled in a range between 3 and 30 nm after densification of the composite coatings on glass at 500 degree(s)C. The third order polarizability (Chi) <SUB>m</SUB><SUP>(3</SUP>) in the metal particles is one order of magnitude higher than in glass composites and exhibits a strong dependence on the ligand.
Supplementary Figure 2 from NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations (2023)

Supplementary Figure 2 from NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations
Bit-Wise Volumetric Optical Memory Utilizing Two-Photon Absorption in Aluminum Oxide Medium (2004)

Aluminum oxide single crystal medium for volumetric optical memory utilizing two-photon absorption is investigated. Static and dynamic testers used to demonstrate bit-wise recording and confocal fluorescent readout. Recording is performed with blue 405 nm laser diodes. Less than 1 nJ of energy per recorded bit was found to be sufficient for data writing. “Negative” readout mode using blue 440 nm laser diode and green 520 nm fluorescence is demonstrated. “Positive” readout mode of operation using red 635 nm excitation laser light and 750 nm fluorescence shows high SNR and prolonged nonvolatile readout. Preliminary data using a dynamic spin-stand tester are presented as well.
Effects of simultaneous circuit and packet switched voice traffic on total capacity. (2006)

Introducing packet switched (PS) voice in cellular systems is often discussed in terms of circuit switched (CS) voice replacement. In this study, we investigate the differences in downlink resource consumption or capacity in a WCDMA system with both CS and PS voice traffic on the same 5 MHz carrier. The PS traffic is gradually increased, representing a migration from CS to a PS only scenario. The study comprises both theoretical calculations and system simulations of downlink voice traffic. The results show that gradually introducing PS voice traffic on the same carrier as CS speech gives equally good or better voice capacity without compromising the QoS requirements. Further on, introducing PS voice on the same carrier can be done in a very flexible way. The CS admission control thresholds can control the power usage for CS, and PS voice can thereafter use the remaining base station power. This means that the CS admission control can decide the ratio of CS and PS voice users, and increase the PS ratio gradually as the PS voice traffic becomes more common
Assessment of clinical burden and practice patterns in patients with chronic hypoparathyroidism in the united states (us): a claims data analysis using diagnosis-based criteria (2021)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Caractérisation d'instances d'apprentissage pour un méta-mining évolutionnaire. (2016)

Les nombreuses techniques d'apprentissage et de fouille de donnees mises au point au cours des dernieres decennies peuvent se reveler d'importants atouts dans divers domaines, mais choisir la technique la plus appropriee pour une application precise est une tâche tres complexe pour un non-expert. Notre objectif est ainsi de produire un assistant de modelisation repondant a ce besoin, par une approche a la frontiere du meta-apprentissage et des heuristiques evolutionnaires. Nous presentons ici le fonctionnement prevu de cet assistant, suivi d'une discussion de notre approche du probleme de caracterisation des instances d'apprentissage, qui reste un verrou majeur du meta-apprentissage et meta-mining.
A Mediator-cohesin axis controls heterochromatin domain formation (2022)

The genome consists of regions of transcriptionally active euchromatin and more silent heterochromatin. We reveal that the formation of heterochromatin domains requires cohesin turnover on DNA. Stabilization of cohesin on DNA through depletion of its release factor WAPL leads to a near-complete loss of heterochromatin domains. We observe the opposite phenotype in cells deficient for subunits of the Mediator-CDK module, with an almost binary partition of the genome into dense H3K9me3 domains, and regions devoid of H3K9me3 spanning the rest of the genome. We suggest that the Mediator-CDK module might contribute to gene expression by limiting the formation of dense heterochromatin domains. WAPL deficiency prevents the formation of heterochromatin domains, and allows for gene expression even in the absence of the Mediator-CDK subunit MED12. We propose that cohesin and Mediator affect heterochromatin in different ways to enable the correct distribution of epigenetic marks, and thus to ensure proper gene expression.
Modelling and Control of Engine Torque for Short-Circuit Flow and EGR Evacuation (2017)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Low-Pressure Exhaust Gas Recirculation (LP-EGR) has been shown to be an effective means of improving fuel economy and suppressing knock in downsized, boosted, spark ignition engines. LP-EGR is particularly beneficial at low-speed, high-load conditions, but can lead to combustion instability at lower loads. The transport delays inherent in LP-EGR systems slow the reduction of intake manifold EGR concentrations during tip-out events, which may lead to excessive EGR concentrations at low load.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;This paper explores leveraging Variable Valve Timing (VVT) as a means of improving the rate of reduction of intake manifold EGR concentration prior to tip-out. At higher boost levels, high valve overlap may result in intake manifold gas passing directly to the exhaust manifold. This short-circuiting behaviour could potentially improve EGR evacuation rates. However, introducing short-circuit flow may lead to lean exhaust flow through the catalyst, and/or necessitate rich in-cylinder conditions that could counteract the fuel economy benefits of increasing high load LP-EGR rates. Therefore, this paper seeks to quantify the improvement in EGR evacuation rate and duration of short circuiting that may be achieved while at boosted conditions with high valve overlap, in preparation for a tip out.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;To conduct this investigation, a controller is first proposed, capable of regulating torque at boosted operating conditions with high valve overlap and external EGR. This controller extends a published control architecture, by accounting for both short-circuit flow and external EGR.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The developed controller is then applied to a GT-Power model to regulate torque during constant torque LP-EGR evacuations, where high valve overlap is shown to improve evacuation times by 15-25%.&lt;/div&gt;&lt;/div&gt;