gebhart/patrepeval huggingface dataset:
QUANTITATIVE MODELING OF SUPPRESSION OF IgG1, IgG2a, IL-2, and IL-4 RESPONSES TO ANTIGEN IN MICE TREATED WITH EXOGENOUS CORTICOSTERONE OR RESTRAINT STRESS (2001)

Exposure to toxic chemicals often induces a neuroendocrine stress response leading to increased concentrations of a variety of potentially immunomodulatory mediators. Corticosterone is a major stress-induced mediator that can be immunosuppressive. However, the quantity of corticosterone exposure required to produce particular decrements in particular immunological parameters is not known. Mice treated with various dosages of exogenous corticosterone were compared to mice exposed to a psychogenic stressor (restraint). Cumulative corticosterone exposure in these mice, expressed as the area under the curve (AUC) of corticosterone concentration versus time, was used to develop quantitative models of the effects of corticosterone on the immunoglobulin (Ig) G1 and IgG2a responses to keyhole limpet hemocyanin (KLH) and sheep erythrocytes (sRBC). The production of interleukin (IL)-2 and IL-4 by splenocytes stimulated with KLH in culture was also evaluated. Linear regression models were derived that describe the relationship between the IgG1 and IgG2a responses to KLH. Restraint had a greater effect (at equivalent corticosterone AUC values) than exogenous corticosterone, suggesting that mediators in addition to corticosterone are important in suppression of the IgG1 and IgG2a response to KLH. The production of IL-2 and IL-4 by cultured splenocytes was mostly, but not always, consistent with the changes in IgG1 or IgG2a. For example, the regression lines for IgG2a (a Th1-driven response) and IL-2 (a Th1 cytokine) were not significantly different. The relationships between corticosterone AUC and the IgG1 and IgG2a responses to sRBC were nonlinear and characterized by enhanced responses at low to moderate AUC values. The quantitative models developed here have implications for risk assessment in immunotoxicology.
Computer Theater: Stage for Action Understanding (1996)

This paper argues that computer theater are an interesting domain for research in action representation, recognition, and generation. Here, computer theater describes experiences and systems where performers use computers in theatrical performances, both as a means to expand their bodies and as partners. Some of the most recent experiences in computer theater are surveyed and classified according to criteria borrowed from computer music research. The possible uses of action understanding are then exemplified by examining our research on script-based control of TV cameras in a cooking show.
A Highly Efficient Generalized Teager-Kaiser-Based Technique for LOS Estimation in WCDMA Mobile Positioning (2005)

Line-of-sight signal delay estimation is a crucial element for any mobile positioning system. Estimating correctly the delay of the first arriving path is a challenging topic in severe propagation environments, such as closely spaced multipaths in multiuser scenario. Previous studies showed that there are many linear and nonlinear techniques able to solve closely spaced multipaths when the system is not bandlimited. However, using root raised cosine (RRC) pulse shaping introduces additional errors in the delay estimation process compared to the case with rectangular pulse shaping due to the inherent bandwidth limitation. In this paper, we introduce a novel technique for asynchronous WCDMA multipath delay estimation based on deconvolution with a suitable pulse shape, followed by Teager-Kaiser operator. The deconvolution stage is employed to reduce the effect of the bandlimiting pulse shape.
Crohn's Disease: Clinical Manifestations and Management (2016)

Crohn's disease is closely related to ulcerative colitis, but is distinguished by key features including anatomic disease location and clinical expression. There are several ways to measure Crohn's disease activity, including clinical symptoms, biological parameters of inflammation, endoscopy, and imaging. The mainstay of diagnostic radiological evaluation of Crohn's disease has been barium small bowel follow through (SBFT). Extraintestinal manifestations of Crohn's disease include eye inflammation, joint involvement, skin manifestations, and biliary involvement. These extraintestinal manifestations may be present in up to 25% of patients, may even be the initial symptom, and may precede bowel inflammation and the diagnosis of Crohn's or ulcerative colitis by months or even years. The differential diagnosis of Crohn's disease includes infections, malignancies, drug-associated, and functional gastrointestinal disorders. The procedure of choice for the definitive treatment of medically refractory ulcerative colitis or ulcerative colitis with dysplasia is total proctocolectomy with ileal pouch-anal anastomosis (IPAA), or J-pouch.
5G R&amp;D Activities for High Capacity Technologies with Ultra High-Density Multi-Band and Multi-Access Layered Cells (2019)

In this paper, we make a summary report of our 5G R&D activities for “High Capacity Technologies with Ultra High-Density Multi-Band and Multi-Access Layered Cells”, funded by the Ministry of Internal Affairs and Communications (MIC) in Japan. This national project consists of three research subjects: “Ultra high-density distributed antenna systems”, “Optical access technologies accommodating highly densified small cells” and “Multi-RAT system technologies for multi-band and multi-access layered cells”. We describe the research and development result for each subject.
Solid phase epitaxy of Bi2Sr2CaCu2Ox superconducting thin films (1993)

Epitaxial superconducting Bi2Sr2CaCu2Ox (BSCCO) thin films have been formed by solid phase epitaxy from amorphous films deposited by metallorganic chemical vapor deposition. (100) MgO and LaAlO3 single crystals were used as the substrates. After high-temperature annealing in flowing oxygen, the films consist predominantly of the BSCCO (2212) phase and are epitaxial to the LaAlO3 with the c axis perpendicular to the substrate surface. The epitaxial structure of the films is confirmed by x-ray diffraction measurements including θ/2θ and in-plane Φ scans as well as by cross-sectional high-resolution transmission electron microscopy. Four-probe resistivity measurements show that the critical temperature of the film on LaAlO3 is 78 K. The critical current density of the epitaxial layer was one order of magnitude greater than that of textured films on MgO.
Investigation of the Iron−Sulfur Cluster in Mycobacterium tuberculosis APS Reductase:  Implications for Substrate Binding and Catalysis (2005)

The sulfur assimilation pathway is a key metabolic system in prokaryotes that is required for production of cysteine and cofactors such as coenzyme A. In the first step of the pathway, APS reductase catalyzes the reduction of adenosine 5'-phosphosulfate (APS) to adenosine 5'-phosphate (AMP) and sulfite with reducing equivalents from the protein cofactor, thioredoxin. The primary sequence of APS reductase is distinguished by a conserved iron-sulfur cluster motif, -CC-X( approximately )(80)-CXXC-. Of the sequence motifs that are associated with 4Fe-4S centers, the cysteine dyad is atypical and has generated discussion with respect to coordination as well as the cluster's larger functional significance. Herein, we have used biochemical, spectroscopic, and mass spectrometry analysis to investigate the iron-sulfur cluster and its role in the mechanism of Mycobacterium tuberculosis APS reductase. Site-directed mutagenesis of any cysteine residue within the conserved motif led to a loss of cluster with a concomitant loss in catalytic activity, while secondary structure was preserved. Studies of 4Fe-4S cluster stability and cysteine reactivity in the presence and absence of substrates, and in the free enzyme versus the covalent enzyme-intermediate (E-Cys-S-SO(3)(-)), suggest a structural rearrangement that occurs during the catalytic cycle. Taken together, these results demonstrate that the active site functionally communicates with the iron-sulfur cluster and also suggest a functional significance for the cysteine dyad in promoting site differentiation within the 4Fe-4S cluster.
ChemInform Abstract: New Ammonia Equivalents for the Pd‐Catalyzed Amination of Aryl Halides. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Controlling conformations and physical properties of meso-tetrakis(phenylethynyl)porphyrins by ring fusion: synthesis, properties and structural characterizations (2004)

The boron trifluoride-catalyzed Rothemund condensations of phenylpropargylaldehyde with 4,7-dihydro-4,7-ethano-2H-isoindole or 3,4-diethylpyrrole in dichloromethane at low temperature give 5,10,15,20-tetrakis(phenylethynyl)porphyrins bearing bicyclo[2.2.2]octadiene and octaethyl substituents, respectively. The former undergoes a retro Diels-Alder reaction to afford 5,10,15,20-tetrakis(phenylethynyl)benzoporphyrin quantitatively. The different conformations of the porphyrin periphery were determined by X-ray diffraction and their redox and spectroscopic properties have been investigated.
Distance-Adaptive Spectrum Allocation in Elastic Optical Path etwork (SLICE) with Bit per Symbol Adjustment (2010)

We present a concept of spectrally-efficient optical networking with distance-adaptive spectral allocation by adjusting the number of modulation levels. We demonstrate it by routing 40 Gb/s optical paths using short-reach, narrow-spectrum 16APSK and long-reach QPSK.
Supplemental Table S3 from Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma (2023)

&lt;p&gt;The primers used in this study.&lt;/p&gt;
Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism (2018)

These results implicate DRD5 as a negative regulator of DRD2 signaling and tumor sensitivity to ONC201 DRD2 antagonism.
Pulse position controlled DS-UWB (2004)

In this paper, a novel UWB system called pulse position controlled UWB is proposed. One of the problems in UWB systems is the restriction of data rates due to multipath. The proposed UWB system shorten the pulse interval adaptively depending on channel characteristics. It has been shown that the proposed UWB system can increase the data rate with about 30% and improve the BER at the same time.
Polarization Effect on Signal from Optical ROM Using Solid Immersion Lens (2000)

In a high-numerical-aperture optical head using a solid immersion lens (SIL), it is anticipated that the polarization of the diffracted beam is disturbed, this affects the signals. To study this problem, a rigorous simulator based on the three-dimensional vector diffraction theory has been developed. Polarization disturbance for various NA s has been estimated and it has been clarified that the polarization is disturbed not only in the SIL head but also in the conventional high- NA head whose disk substrate is not covered with protective glass. The influence of polarization disturbance on the readout signals has been determined and discussed for the various polarizations.
Architectural support for security management in enterprise networks (2007)

Enterprise networks are often large, run a wide variety of applications and protocols, and operate under strict reliability constraints; thus, they represent a challenging environment for security management. Security policies in todays enterprise are typically enforced by regulating connectivity with a combination of complex routing and bridging policies along with various interdiction mechanisms such as ACLs, packet filters, and middleboxes that attempt to retrofit access control onto an otherwise permissive network architecture. This leads to networks that are inflexible, fragile, difficult to manage, and still riddled with security problems. 
This thesis presents a principled approach to network redesign that creates more secure and manageable networks. We propose a new network architecture in which a global security policy defines all connectivity. The policy is declared at a logically centralized Controller and then enforced directly at each switch. All communication must first obtain permission from the Controller before being forwarded by any of the network switches. The Controller manages the policy namespace and performs all routing and access control decisions, while the switches are reduced to simple forwarding engines that enforce the Controller's decisions. 
We present an idealized instantiation of the network architecture called SANE. In SANE, the Controller grants permission to requesting flows by handing out capabilities (encrypted source routes). SANE switches will only forward a packet if it contains a valid capability between the link and network headers. SANE thus introduces a new, low-level protection layer that defines all connectivity on the network. 
SANE would require a fork-lift replacement of an enterprise's entire networking infrastructure and changes to all the end-hosts. While this might be suitable in some cases, it is clearly a significant impediment to widespread adoption. To address this, we present Ethane a deployable instantiation of our architecture. Ethane does not require modification to end-hosts and can be incrementally deployed within an existing network. Instead of handing out capabilities, permission is granted by explicitly setting up flows at each switch. We have implemented Ethane in both hardware and software, supporting both wired and wireless hosts. We describe our experience managing an operational Ethane network of over 300 hosts.
TLR8 agonist VTX-2337 enhances NKG2D-mediated cytotoxicity of NK cells (2013)

Meeting abstracts NK cells express an array of activating and inhibitory receptors, which facilitate the recognition and lysis of virally infected and transformed cells, but safeguard healthy cells from attack. NKG2D is an activating receptor expressed on the surface of NK cells that recognizes the
Lithography for manufacturing of sub-65nm nodes and beyond (2006)

Lithography is facing unprecedented difficulties to go beyond the 65-nm node with 90-nm half pitch. This presentation shows the types of lithography combined with necessary resolution enhancement techniques to handle the 65-, 45-, 32-, and 22-nm nodes. The pros and cons, feasibility for manufacturing, and economical impacts of these technologies will be compared
Effects of acid oxidation on carbon nanotube based electrodes for detection of oxidized LDL (2013)

Carbon nanotubes are sometimes treated with an acid or mixture of acids to increase their solubility. From results of our study of single-walled carbon nanotubes, we reported that a CNT-based electrode can detect oxidation of low density-lipoproteins. As described herein, we investigated the effects of acid treatment time on electrode sensitivity for detection of oxidized low-density lipoproteins. Response capabilities of CNT-based electrodes for detecting ox-LDL were improved by acid treatment. However, further increased treatment time degraded their sensitivity. Although detailed mechanisms related to the response are under investigation, results show that an optimum condition exists for acid treatment condition to detect ox-LDL using an electrode.
Litomosoides cariniiin jirds (Meriones unguiculatus): ability to retard development of challenge larvae can be transferred with cells and serum (1984)

To test the ability of cells and/or serum from jirds (Meriones unguiculatus) infected with Litomosoides carinii to transfer the ability to retard development of challenge larvae, a series of transfer experiments were done. Groups of jirds received larval challenge preceded by one of eight preparations: spleen cells and/or serum from 10-day-patent infected jirds; normal spleen cells and/or normal serum; primary larvae; challenge larvae only. No significant differences in size or numbers of larvae recovered were found among groups receiving either cells or serum only. However, significant differences in larval size were found between groups receiving both cells and serum from infected donors and those receiving normal cells and serum. These comparisons indicate that the ability of infected jirds to retard development of challenge infection larvae can be transferred with cells and serum together but not separately.
Recent findings on epigenetic gene abnormalities involved in uterine cancer (2017)

Selective aberrant genetic effects that do not depend on abnormal DNA sequences are referred to as epigenetic abnormalities and are involved in carcinogenesis. In uterine cancer, various genes involved in apoptosis, cell cycle, DNA repair, cell proliferation and cell adhesion are abnormally methylated, resulting in gene silencing. Reversal of such epigenetic abnormalities in cancer cells is a potential strategy for cancer therapy, and studies on epigenetic abnormalities and treatment methods in uterine cancer are in progress. These include the evaluation of 5-hydroxymethylcytosine, which is present in cancer tissues at lower levels compared with those in normal tissues, as a prognostic marker in cervical cancer; combination therapy with 5-azacytidine and cisplatin; combination treatment focusing on tumor necrosis factor-related apoptosis-inducing ligand in cervical cancer; studies focusing on DNA mismatch repair in endometrial cancer; and use of a demethylating agent to reactivate tumor suppressor genes and inhibit tumor proliferation. Detection of epigenetic changes using biomarkers may be used for histological classification, evaluation of disease progression and identification of compounds that are able to modulate epigenetic changes and may be useful for uterine cancer treatment.
Creation and preclinical evaluation of a novel mussel-inspired, biomimetic, bioactive bone graft scaffold: direct comparison with Infuse bone graft using a rat model of spinal fusion (2023)

Implantation of rhBMP-2-adsorbed BioMim-PDA scaffolds resulted in BV and bone quality superior to that afforded by treatment with rhBMP-2 concentrations 10-fold higher implanted on a conventional collagen sponge. Using BioMim-PDA (vs a collagen sponge) for rhBMP-2 delivery could significantly lower the amount of rhBMP-2 required for successful bone grafting clinically, improving device safety and decreasing costs.
Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor Reverses Neutropenia and Reduces Secondary Infections in Visceral Leishmaniasis (1994)

Twenty-four patients with acute visceral leishmaniasis and leukopenia (< 1500 neutrophils/mm3) due to Leishmania chagasi were studied, 4 in an open-label pilot study and 20 in a double-blind, placebo-controlled trial. Patients received granulocyte-macrophage colony-stimulating factor (GM-CSF), 5 micrograms/kg daily, or placebo for 10 days, plus 10-20 mg/kg pentavalent antimony daily for 20 days. In GM-CSF recipients, neutrophil counts increased threefold and fourfold over baseline at 5 and 10 days, respectively, and were significantly higher than those in placebo recipients (P < .02). Eosinophil and monocyte counts were significantly increase in GM-CSF recipients at 10 days (P < or = .03). Secondary infections occurred in 3 GM-CSF and in 8 placebo recipients (P = .04). All patients had complete resolution of their leishmaniasis at 3 months. Few adverse events were recorded. GM-CSF, 5 micrograms/kg daily for 10 days, was safe, rapidly reversed neutropenia, and reduced the number of secondary infections in patients with leishmaniasis.
Evaluation of work function of the catalytic electrode in the fuel cells (2013)

The fuel cell was fabricated on the sensing plate and the catalytic reaction of the electrode was measured using terahertz chemical microscope. Change in the amplitude of THz at the catalytic cathode and anode could be observed.
Novel High-Intensity Focused Ultrasound Clamp—Potential Adjunct for Laparoscopic Partial Nephrectomy (2012)

In this preliminary porcine evaluation, a novel HIFU clamp induced hemostasis and created an ablation plane in the kidney. This technology could serve as a useful adjunct to laparoscopic PN in the future and potentially obviate the need for renal hilar clamping.
A new preprocessor for the SP-3000 series of time-of-flight positron emission tomographs (1993)

A new preprocessor for the University of Washington modified SP-3000 positron emission tomograph was designed and built. The device improves the maximum coincidence counting rate of the machine to greater than 450000 events per second in preprocessed mode. The new hardware also improves image quality by implementing time-of-flight offset corrections by crystal pairs, position and time-of-flight gating for the rotating sector source (for attenuation scans), and supporting corrections of randoms based on estimating singles rates from rejected time-of-flight events. The improved hardware can be installed on any SP-3000 series tomograph with modest modifications to calibration and data acquisition software.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
[Role of computed tomography in the diagnosis of complications of lumbar disk surgery]. (1986)

Recurrence of symptomatology after diskectomy was investigated in 37 patients by computed tomography imaging. Local complications were mainly fibrous scar tissue formation and recurrence of disk lesions. Results showed the CT scan to be the most reliable exploratory procedure available at the present time, based on the quality of images obtained after intravenous iodized contrast injection.
UTD-MHAD: A multimodal dataset for human action recognition utilizing a depth camera and a wearable inertial sensor (2015)

Human action recognition has a wide range of applications including biometrics, surveillance, and human computer interaction. The use of multimodal sensors for human action recognition is steadily increasing. However, there are limited publicly available datasets where depth camera and inertial sensor data are captured at the same time. This paper describes a freely available dataset, named UTD-MHAD, which consists of four temporally synchronized data modalities. These modalities include RGB videos, depth videos, skeleton positions, and inertial signals from a Kinect camera and a wearable inertial sensor for a comprehensive set of 27 human actions. Experimental results are provided to show how this database can be used to study fusion approaches that involve using both depth camera data and inertial sensor data. This public domain dataset is of benefit to multimodality research activities being conducted for human action recognition by various research groups.
Automatic Label Data Abstraction Based on Information Entropy (Application Paper) (2016)

There is currently a big demand for automating big data analysis. In the data analysis field, data abstraction or summarization playes an important role in the extraction of generalized information from large scale data. We developped an artificial intelligence computer system with the aim of automating big data analysis and came up with a method that can abstract numerical type data (age, height, time, etc.). However, it could not abstract or summarize label type data (customer ID, product code, name, etc.). In the present work, we have developed a label abstraction method based on information entropy. Experiments using open real data showed that the proposed method achieved an extraction accuracy of 80% evaluated by f measure. We intended to apply the proposed method to our artificial intelligence and perform further evaluations.