gebhart/patrepeval huggingface dataset:
A pilot study of neoadjuvant cetuximab in locally advanced squamous cell carcinomas of skin (SCCS). (2015)

TPS9092 Background: The incidence of SCCS has increased over the past two decades, including a high risk subset with aggressive behavior. Due to a lack of high-quality clinical trials in this population, there is no standard systemic therapy for advanced SCCS. The epidermal growth factor receptor (EGFR), often highly expressed in SCCS, is implicated in UV-induced skin carcinogenesis and SCCS development. Cetuximab, a monoclonal antibody that competitively inhibits EGFR, improved disease control as first line therapy in unresectable SCCS in a single arm phase II trial. Despite impressive responses with cetuximab in some, most treated SCCS patients do not respond, and there is a need for predictive biomarkers. We hypothesize that the use of cetuximab will improve clinical outcomes in patients with advanced SCCS in the neoadjuvant setting, and that measures of antibody dependent cytotoxicity (ADCC) in tumor and/or specific genomic features of the tumor may predict response to therapy. Methods: In this pilot trial (NCT 02324608), we will enroll 20 patients with relapsed locally advanced SCCS or SCCS unamenable to definitive local therapy. The primary endpoint will measure response rate to cetuximab by RECIST criteria with secondary endpoints of progression free and overall survival, and conversion to resectability. Molecular tumor correlates include analyzing DNA mutations and measuring downstream activation of EGFR signaling and ADCC, correlating these with clinical benefit. Patients will receive cetuximab at 400mg/m2 Χ 1 followed by weekly doses of 250mg/m2 for 8 weeks prior to surgery. Patients will be evaluated for subsequent definitive surgical resection, or definitive radiotherapy if surgical resection is not possible. Postoperative adjuvant radiotherapy will be permitted. Patients will undergo pretreatment biopsies, and post-treatment tissue will be harvested at surgery or through a biopsy at the conclusion of cetuximab. Paired skin and tumor samples will be evaluated through partial DNA (FoundationOneΤΜ) and RNA sequencing, IHC analysis of EGFR signaling components, and measurement of ADCC. The trial is currently screening eligible subjects. Clinical trial information: 02324608.
A model for digital sweat sensing devices (2022)

Sweat is a biomarker-rich fluid that contains information that can provide insights into the metabolic activity of the patient. To interpret the information from certain biomarkers the sweat rate of each gland needs to be known. An agent-based model was created to explore the potential improvement of current methods to obtain the sweat rate per gland. In a digital sweat sensing device, the continuous sweat flow is discretized into individual droplets. These droplets are detected by a sensor to create a signal. The model simulates these signals for different device designs and parameters. The model shows how different design choices can influence the signal. The results demonstrate the utility of the model, for both the development of a signal analysis method and the subsequent optimization of the device design.
Event-shape engineering for inclusive spectra and elliptic flow in Pb-Pb collisions atsNN=2.76TeV (2016)

We report on results obtained with the event-shape engineering technique applied to Pb-Pb collisions at $\sqrt{{s}_{\mathit{NN}}}=2.76$ TeV. By selecting events in the same centrality interval, but with very different average flow, different initial-state conditions can be studied. We find the effect of the event-shape selection on the elliptic flow coefficient ${v}_{2}$ to be almost independent of transverse momentum ${p}_{\mathrm{T}}$, which is as expected if this effect is attributable to fluctuations in the initial geometry of the system. Charged-hadron, -pion, -kaon, and -proton transverse momentum distributions are found to be harder in events with higher-than-average elliptic flow, indicating an interplay between radial and elliptic flow.
Toughness Improvement of Resistance-Butt Welded Joints in Steel (2016)

The development of welding technologies with high productivity is very important in the field of welding. One shot welding methods, such as upset/flash welding, are essentially very fast can meet this requirement. However, their fracture toughness has generally been unacceptable, which has been considered to be an essential week point. In this report, to improve the toughness of upset/flash welds are examined. The factors affecting flash weld toughness are summarized, and the improvement methods are discussed. Based on the results of several studies, ways to improve toughness are considered to the cleaning of the weld interface by way of oxide extrusion on upsetting and grain refining of the microstructures in the heat-affected zone (HAZ). One solution is the use of pulsed high current to concentrate resistance heat on the contact area and minimize total heat input. Homopolar pulse welding (HPW), which can supply very high current through the homopolar generator, has been examined for this purpose. The weld toughness of high tensile strength steel and high Chromium martensitic stainless steel was examined. Homopolar welds showed acceptable toughness and the values of high Chromium stainless steel were comparable with those of the base metal. The HAZs were narrow with fine-grained microstructures, and no discernible localized softened regions were observed. The fine-grained microstructure of HPW welds results from the combination of its rapid thermal excursion and deformation while upsetting. Sufficient plastic deformation also makes it possible to obtain defect free welds without localized softened regions. From these results, this pulsed high current welding methods has been found to play a role in the improvement of fracture toughness.
Wireless Local Area Networks with Multiple-Packet Reception Capability (2007)

Thanks to its simplicity and cost efficiency, wireless local area network (WLAN) enjoys unique advantages in providing high-speed and low-cost wireless services in hot spots and indoor environments. Traditional WLAN medium-access-control (MAC) protocols assume that only one station can transmit at a time: simultaneous transmissions of more than one station causes the destruction of all packets involved. By exploiting recent advances in PHY-layer multiuser detection (MUD) techniques, it is possible for a receiver to receive multiple packets simultaneously. This paper argues that such multipacket reception (MPR) capability can greatly enhance the capacity of future WLANs. In addition, it provides the MAC-layer and PHY-layer designs needed to achieve the improved capacity. First, to demonstrate MUD/MPR as a powerful capacity-enhancement technique, we prove a "super-linearity" result, which states that the system throughput per unit cost increases as the MPR capability increases. Second, we show that the commonly deployed binary exponential backoff (BEB) algorithm in today's WLAN MAC may not be optimal in an MPR system, and that the optimal backoff factor increases with the MPR capability: the number of packets that can be received simultaneously. Third, based on the above insights, we design a joint MAC-PHY layer protocol for an IEEE 802.11-like WLAN that incorporates advanced PHY-layer blind detection and MUD techniques to implement MPR
Protein Nanofibrils for Sustainable Food–Characterization and Comparison of Fibrils from a Broad Range of Plant Protein Isolates (2021)

Protein nanofibrils (PNFs) from plant-based protein sources have great potential for use in new sustainable food applications or biobased materials. Plant-based proteins from seven different sources (fava bean, mung bean, lupin, oat, rapeseed, soybean, and potato) were evaluated here for their ability for forming PNFs and compared with whey protein PNFs. Formation of PNFs was studied under incubation at acidic conditions (pH 2) and heat (85–90 °C) for 24–96 h. Presence of PNFs was detected using thioflavin T, circular dichroism spectroscopy, Fourier-transform infrared spectroscopy, and atomic force microscopy. The results showed that all plant-based proteins were able to form PNFs. For some of the plant protein isolates in this study, nanofibril formation is reported for the first time. We also describe and compare the distinct features associated with each protein source and the morphological alterations of the nanoscale structures. Finally, we describe how PNF production can be enhanced by purifying the fibril-forming protein component. Taken together, our study suggests that the structural and functional variation within plant protein nanofibrils can be exploited in future scaled-up food or material applications.
In vivo wireless body communications: State-of-the-art and future directions (2015)

The emerging in vivo communication and networking system is a prospective component in advancing health care delivery and empowering the development of new applications and services. In vivo communications construct wirelessly networked cyber-physical systems of embedded devices to allow rapid, correct and cost-effective responses under various conditions. This paper surveys the existing research which investigates the state of art of the in vivo communication. It also focuses on characterizing and modeling the in vivo wireless channel and contrasting this channel with the other familiar channels. MIMO in vivo is as well regarded in this overview since it significantly enhances the performance gain and data rates. Furthermore, this paper addresses current challenges and future research areas for in vivo communications.
Studies in computational number theory with applications to cryptography (1996)

We study various number theoretic problems that arise from cryptographic protocols. Our results are used to prove the security of new and existing protocols. The thesis is divided into five parts. We begin by studying algebraic algorithms which are a weak model of computation suitable for modeling number theoretic algorithms. We prove a hardness criteria for algebraic algorithms and present several number theoretic consequences of this result. Next we study black box fields and show how they can be used to break algebraically homomorphic encryption schemes. These algorithms show that over the group of points of an elliptic curve the hardness of computing discrete-log implies the security of the Diffie-Hellman protocol. We go on to study the security of portions of the Diffie-Hellman secret. We show that $\sqrt{{\rm log} p}$ bits of the Diffie-Hellman secret are as hard to compute as the whole secret. Furthermore, in some cases the individual most significant bit is sufficient. These results lead us to suggest a new variant of the Diffie-Hellman protocol for which the most significant bit of the secret is hard to compute. The fourth part generalizes the Coldreich-Levin theorem to arbitrary finite groups and describes some applications to learning. Finally in the last chapter we study a coding theory problem which arises from the problem of fingerprinting digital data.
Structure‐Based Analysis and Optimization of a Highly Enantioselective Catalyst for the Strecker Reaction. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Resurfacing arthroplasty of the humerus: indications, surgical technique, and clinical results (2008)

Resurfacing arthroplasty of the shoulder is not a new concept in orthopedic surgery. Although only a few reports describe the indications, technique, and results, experience with these devices continues to grow. A specific advantage of resurfacing arthroplasty, the concept of a bone-preserving procedure, may prove to be particularly important in younger patients who require prosthetic arthroplasty surgery. The indications and surgical technique are illustrated in this review. Our early clinical results with 2 humeral resurfacing prostheses reflect those of other published reports; namely, favorable clinical outcomes can be expected.
Reduced losses in die-cast machines with insulated rotors (2009)

This paper reports an investigation into the influence of inter-bar currents on the performance of die-cast cage induction machines. The work is based on an extensive set of experimental measurements using a series of specially made die-cast cage induction motors with bars insulated using alternate processes. The observations arising from the test results are reinforced by predictions made using an analytical model. The work in this study shows that increasing the insulation of the rotor cage will reduce loss and thereby improve the efficiency. This premise is demonstrated both experimentally and analytically. The efficiency gain can be attributed to the inhibition of the flow of inter-bar currents.
Living radical polymerization. II. Improved atom transfer radical polymerization of acrylamide in aqueous glycerol media with a novel pentamethyldiethylenetriamine‐based soluble copper(I) complex catalyst system (2004)

Abstract An improved atom transfer radical polymerization (ATRP) of acrylamide was achieved in a glycerol/water (1:1 v/v) medium with 2‐halopropionamide initiators, Cu X (X = Cl or Br) as catalysts, pentamethyldiethylenetriamine (PMDETA) as a ligand, and Cu X 2 (≥20 mol % Cu X ) and excess alkali halide (ca. 1 mol/dm 3 ) as additives. The first‐order kinetic plots for the disappearance of the monomer at 130 °C were linear; this was a significant improvement over the results obtained earlier with the bipyridine ligand. However, even under such improved situations, about 7 mol % of the polymer chains were estimated to be formed dead. The polydispersity index was approximately 1.5. At a lower temperature (ca. 90 °C), a lower polydispersity index (1.24) was obtained for the bromide‐based initiating system. Chain‐extension experiments proved the living nature of the polymers. The presence of both extra halide ions and the monomer was necessary to take the Cu X –PMDETA complex into solution. It was suggested that the soluble Cu(I) complex was formed with one PMDETA molecule acting as a monodentate ligand and with two halide ions and one acrylamide molecule occupying the other three coordination sites. Some support for the involvement of all three ligands (X − , PMDETA, and acrylamide) in the complex formation was obtained from ultraviolet–visible spectroscopy studies. The better ATRP with the PMDETA ligand was attributed to the better stability and lesser hydrolysis of the 1:1 Cu +2 /PMDETA complex with respect the corresponding bipyridine complex. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 2483–2494, 2004
Supplementary Table S4 from Systematic Interrogation of 3q26 Identifies <i>TLOC1</i> and <i>SKIL</i> as Cancer Drivers (2023)

&lt;p&gt;Supplementary Table S4 - XLSX file 44K, Proteins that have been reported to associate with the TLOC1 Drosophila melanogaster ortholog Trp1&lt;/p&gt;
Cross-modal Learning of Graph Representations using Radar Point Cloud for Long-Range Gesture Recognition (2022)

Gesture recognition is one of the most intuitive ways of interaction and has gathered particular attention for human computer interaction. Radar sensors possess multiple intrinsic properties, such as their ability to work in low illumination, harsh weather conditions, and being low-cost and compact, making them highly preferable for a gesture recognition solution. However, most literature work focuses on solutions with a limited range that is lower than a meter. We propose a novel architecture for a long-range (1m – 2m) gesture recognition solution that leverages a point cloud-based cross-learning approach from camera point cloud to 60-GHz FMCW radar point cloud, which allows learning better representations while suppressing noise. We use a variant of Dynamic Graph CNN (DGCNN) for the cross-learning, enabling us to model relationships between the points at a local and global level and to model the temporal dynamics a Bidirectional Long short-term memory (LSTM) network is employed. In the experimental results section, we demonstrate our model's overall accuracy of 98.4% for five gestures and its generalization capability.
Abstract 1143: Translational control analysis by translationally active RNA capture/microarray analysis (TrIP-Chip) (2010)

Abstract We have developed a new approach to systematically study post-transcriptional regulation in a small number of cells. Actively translating mRNAs are associated with polysomes and the newly synthesized peptide chains are closely associated with molecular chaperones such as hsp70s, which assist in the proper folding of nascent polypeptides into higher ordered structures. These chaperones provide an anchor with which to separate actively translating mRNAs associated with polysomes from free mRNAs. Affinity capture beads were developed to capture hsp70 chaperones associated with the polysome complexes. The isolated actively translating mRNAs were used for high throughput expression profiling analysis. Feasibility was demonstrated using an in vitro translation system with known translationally regulated mRNA transcript thymidylate synthase (TS). We further developed the approach using HCT-116 colon cancer cells with both TS and p53 as positive controls. The steady state levels of TS and p53 mRNAs were unaltered after 5-fluorouracil (5-FU) treatment as assessed by real time qRT-PCR analysis. In contrast, the protein expression and polysome-associated mRNA levels of both genes were increased. These differences in translational rate were revealed with our new approach from 500 cells. This technology has the potential to make investigation of translational control feasible with limited quantities of clinical specimens. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1143.
Examining HIV Viral Load in a Matched Cohort of HIV Positive Individuals With and Without Psoriasis. (2017)

BACKGROUND: HIV-associated psoriasis is well-documented. Genetic, cellular, and cytokine profiles have been used as evidence to suggest psoriasis activates antiviral pathways. There has been a lack of epidemiologic evidence investigating whether psoriasis patients have lower HIV viral counts compared to non-psoriasis patients. OBJECTIVE: Compare the viral load set point of HIV positive patients with and without psoriasis. METHODS: A retrospective matched cohort study of HIV positive patients with and without psoriasis using the Kaiser Permanente Southern California Health Plan database. RESULTS: We identified 101 HIV-positive psoriasis cases; 19 met inclusion criteria and were matched with 3-5 control patients; 94 total patients were analyzed. The mean age was 41.4 (12.07) years and 83% were male. Overall, the median log of the viral load of cases was slightly higher than controls (4.3 vs 4.2; P less than 0.01). CONCLUSIONS: The serum viral load set point of patients with HIV and psoriasis was slightly higher than the viral load set point of HIV patients without psoriasis. <em>J Drugs Dermatol. 2017;16(4):372-377.</em> .
ChemInform Abstract: KATALYTISCHE OXIDATIVE DEHYDRIERUNG VON KOHLENWASSERSTOFFEN 4. MITT. SELEKTIVITAET DER ISOPRENBLDG.‐RK. (1970)

Abstract Die Selektivität der oxidativen Dehydrierung von Isopentengemischen (I) zu Isopren (II) an den binären Katalysatoren U‐Sb, Sn‐Sb und Bi‐Mo wurde untersucht.
Fast and Precise Glass Handling Using Visual Servo With Unscented Kalman Filter Dual Estimation (2017)

In the protective glass manufacturing industry for cell phones, placing glass pieces into the slots of the grinder requires submillimeter accuracy which only can be achieved by human workers, leading to a bottle neck in the production line. To address such issue, industrial robot equipped with vision sensors is proposed to support human workers. The high placing performance is achieved by a two step approach. In the first step, an eye-to-hand camera is installed to detect the glass piece and slot with robust vision, which can put the glass piece close to the slot and ensures a primary precision. In the second step, a closed-loop controller based on visual servo is adopted to guide the glass piece into the slot with dual eye-in-hand cameras. However, vision sensor suffers from a very low frame rate and slow image processing speed resulting in a very slow placing performance. In addition, the placing performance is substantially limited by the system parameter uncertainty. To compensate for these limitations, a dual-rate unscented Kalman filter (UKF) with dual-estimation is adopted for sensor data filtering and online parameter identification without requiring any linear parameterization of the model. Experimental results are presented to confirm the effectiveness of the proposed approach.
Testicular sperm is superior to ejaculated sperm for ICSI in cryptozoospermia: An update systematic review and meta-analysis (2018)

Intracytoplasmic sperm injection (ICSI) is well established and provides patients with severely impaired sperm quality with an opportunity to father a child. However, previous studies do not clearly indicate whether male with cryptozoospermia should use testicular sperm or ejaculated sperm for ICSI. The newest systematic review of this topic also gave a controversial conclusion that was based on incorrect pooling result. Moreover, two clinical studies published after the systematic review. In the present update systematic review and meta-analysis, a comprehensive citation search for relevant studies was performed using the Cochrane library databases, Embase, Ovid MEDLINE, PubMed, ScienceDirect, Scopus, and Web of Science up to September 2017. The search returned 313 records, in which six studies were included in quantitative synthesis. These studies involved 578 male infertility patients who had undergone 761 ICSI cycles. The risk ratios favour fresh testicular sperm for good quality embryo rate (1.17, 95% CI 1.05-1.30, P = 0.005), implantation rate (95% CI 1.02-2.26, P = 0.04), and pregnancy rate (RR = 1.74, 95% CI 1.20-2.52, P = 0.004). In conclusion, the existing evidence suggests that testicular sperm is better than ejaculated sperm for ICSI in male with cryptozoospermia.
Rapid Prototyping for Microfluidics and Neuro-Engineering (2015)

International audience
Effective Thermal Conductance from a Thin Film into Liquid Helium (1964)

The steady-state thermal dissipation from heat-generating thin-film strips, immersed in liquid helium, has been examined by measuring the thermal hysteresis of the magnetically induced resistive transition of superconducting thin films of tin, deposited onto glass and aluminum substrates. The dissipated heat was found to depend linearly on the temperature difference between the film strip and the helium bath. It was thus possible to characterize the heat transfer by an effective coefficient of heat transfer that was approximately ten times as great for films on aluminum substrates as for films on glass substrates. For a 0.12-×2.3- mm2 film strip, its value was approximately 8×10−3 W/°K for the aluminum substrate, approximately 9×10−4 W/°K for the glass substrate. The coefficient was also dependent on the nature of other thin films deposited beneath or above the film strip. Analysis of the data indicated that the thermal conductance between the film strip and the helium bath was about 0.1 W/cm2 °K, and the thermal conductance between the film strip and the aluminum about 1.7 W/cm2 °K.