gebhart/patrepeval huggingface dataset:
491: Molecular Tumor Profiling Improves Risk Assessment and Prognostication of Patients with Non-Metastatic Clear Cell Renal Cell Carcinoma (2007)

You have accessJournal of UrologyModerated Poster 14, Sunday, May 20, 2007, 3:30 - 5:30 pm1 Apr 2007491: Molecular Tumor Profiling Improves Risk Assessment and Prognostication of Patients with Non-Metastatic Clear Cell Renal Cell Carcinoma Tobias Klatte, David B. Seligson, Allan J. Pantuck, John T. Leppert, Stephen B. Riggs, John S. Lam, Nazy Zomorodian, Fairooz F. Kabbinavar, and Arie S. Belldegrun Tobias KlatteTobias Klatte More articles by this author , David B. SeligsonDavid B. Seligson More articles by this author , Allan J. PantuckAllan J. Pantuck More articles by this author , John T. LeppertJohn T. Leppert More articles by this author , Stephen B. RiggsStephen B. Riggs More articles by this author , John S. LamJohn S. Lam More articles by this author , Nazy ZomorodianNazy Zomorodian More articles by this author , Fairooz F. KabbinavarFairooz F. Kabbinavar More articles by this author , and Arie S. BelldegrunArie S. Belldegrun More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30731-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "491: Molecular Tumor Profiling Improves Risk Assessment and Prognostication of Patients with Non-Metastatic Clear Cell Renal Cell Carcinoma." The Journal of Urology, 177(4S), p. 164 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 164 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Tobias Klatte More articles by this author David B. Seligson More articles by this author Allan J. Pantuck More articles by this author John T. Leppert More articles by this author Stephen B. Riggs More articles by this author John S. Lam More articles by this author Nazy Zomorodian More articles by this author Fairooz F. Kabbinavar More articles by this author Arie S. Belldegrun More articles by this author Expand All Advertisement PDF DownloadLoading ...
The copper hydride (CuH) + atomic hydrogen copper + molecular hydrogen matrix phase reaction (1984)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTThe copper hydride (CuH) + atomic hydrogen copper + molecular hydrogen matrix phase reactionGeoffrey A. Ozin and Catherine GracieCite this: J. Phys. Chem. 1984, 88, 4, 643–645Publication Date (Print):February 1, 1984Publication History Published online1 May 2002Published inissue 1 February 1984https://pubs.acs.org/doi/10.1021/j150648a001https://doi.org/10.1021/j150648a001research-articleACS PublicationsRequest reuse permissionsArticle Views213Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Towards Exploring Fundamental Limits of System-Specific Cryptanalysis Within Limited Attack Classes: Application to ABSG (2008)

A new approach on cryptanalysis is proposed where the goal is to explore the fundamental limits of a specific class of attacks against a particular cryptosystem. As a first step, the approach is applied on ABSG, which is an LFSR-based stream cipher where irregular decimation techniques are utilized. Consequently, under some mild assumptions, which are common in cryptanalysis, the tight lower bounds on the algorithmic complexity of successful Query-Based Key-Recovery attacks are derived for two different setups of practical interest. The proofs rely on the concept of ``typicality'' of information theory.
TD-LTE — The radio-access solution for IMT-Advanced/TDD (2010)

This paper provides a discussion on the LTE radio-access technology as defined in 3GPP, with specific focus on its TDD component (TD-LTE). Some specific characteristics of TDD, such as interference between uplink and downlink as well as channel reciprocity, are outlined. A discussion on possible evo
Search for new physics in events with same-sign dileptons and jets in pp collisions at $ \sqrt{s} $ = 8 TeV (2014)

A search for new physics is performed based on events with jets and a pair of isolated, same-sign leptons. The results are obtained using a sample of proton-proton collision data collected by the CMS experiment at a centre-of-mass energy of 8 TeV at the LHC, corresponding to an integrated luminosity of 19.5 fb -1 . In order to be sensitive to a wide variety of possible signals beyond the standard model, multiple search regions defined by the missing transverse energy, the hadronic energy, the number of jets and bquark jets, and the transverse momenta of the leptons in the events are considered. No excess above the standard model background expectation is observed and constraints are set on a number of models for new physics, as well as on the same-sign top-quark pair and quadruple-top-quark production cross sections. Information on event selection efficiencies is also provided, so that the results can be used to confront an even broader class of new physics models.
Phenotypic Alteration of Carbohydrate Antigens in Gynecological Malignancy. (1995)

Two monoclonal antibodies termed MSN-1 and MRG-1 were raised against endometrial cancer cell line SNG-ll and ovarian mucinous cystadenocarcinoma cell line RMUG-L, respectively, and were found to recognize carbohydrate antigens, Lewis b (Leb) and bloodgroup A type 3 structures, respectively. Using these monoclonal antibodies, we examined phenotypic alterations of the corresponding carbohydrate antigens in gynecological malignancies including uterine cervical and endometrial cancers.Additionally, since galactosyltransferase associated with tumor (GAT), which is derived from cellular galactosyltransferase (GaIT), is frequently elevated specifically in the sera of patients with ovarian cancer, the localization of GaIT and GAT was investigated in malignant ovarian tumors. Light-microscopically, MSN-1 gave a positive reaction in more than 90% of the cases of endometrial cancers. The suborganellar localizations of MSN-1-reactive antigen in the cancer cells were almost all in the cisternae of the Golgi, while the normal endometrial glandular cells showed a few positive signals in the trans-Golgi only. Using MRG-1 we investigated uterine cervical squamous epithelial lesions as well as their normal counterparts. Normal squamous epithelium showed a strong positive reaction exclusively along the cell surface. MRG-1-binding sites in squamous cell carcinoma were not only along the cell surface but also in the cytoplasmic space where they resided on vesicular structures, as observed at the electron microscopic level. To detect the galactosyltransferase, we employed two monoclonal antibodies, Mab8628 and Mab8513. Mab8628 strongly stained intracytoplasmic structures in ovarian cancer cells that coincided with the trans-Golgi, as observed with the electron microscope. When Mab8513, which can recognize GAT more specifically than Mab8628, was applied to endometrial cancer and normal cells, an increase in the positive signals was found in cancer cells. These histochemical analyses demonstrated that the localization and/or amount of complex carbohydrates as well as glycosyltransferase is altered between cancer cells and their normal counterparts.
Efficient equivalence checking of multi-phase designs using retiming (1998)

Article Free Access Share on Efficient equivalence checking of multi-phase designs using retiming Authors: Gagan Hasteer Ambit Design Systems Ambit Design SystemsView Profile , Anmol Mathur Ambit Design Systems Ambit Design SystemsView Profile , Prithviraj Banerjee Northwestern University Northwestern UniversityView Profile Authors Info & Claims ICCAD '98: Proceedings of the 1998 IEEE/ACM international conference on Computer-aided designNovember 1998 Pages 557–562https://doi.org/10.1145/288548.289086Published:01 November 1998Publication History 7citation128DownloadsMetricsTotal Citations7Total Downloads128Last 12 Months5Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
ChemInform Abstract: Cyclic Conjugated Enediynes via Elimination of a Thionocarbonate in a Latent Z‐Hex‐3‐ene‐1,5‐diyne Unit. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
MOCVD of CoAl2O4 Thin Films from {Co[Al(OiC3H7)4]2} as Precursor (2007)

A new synthetic route for the deposition of CoAl2O4 thin films at low temperature via MOCVD using the single-source precursor {Co[Al(OiC3H7)4]2} is presented. Molecular properties of {Co[Al(OiC3H7)4]2} have been investigated by means of NMR spectroscopy, mass spectrometry, and thermal analysis. Deposits have been characterized by XRD, AFM, UV−vis, and SIMS measurements.
Abstract B241: Targeting the mitotic checkpoint with NMS-P153, a novel MPS1 kinase inhibitor. (2011)

Abstract Aneuploidy is one of the major hallmarks of cancer and is a unique property of tumoral cells. Thus, targeting the molecular mechanisms required for the growth of aneuploid cells might be expected to yield more cancer cell specific therapeutic approaches. The Spindle Assembly Checkpoint (SAC) is a mitotic mechanism required for proper chromosomal segregation, ensuring that cells do not divide until all sister chromatids correctly align to the metaphase plate. It is a complex machinery tightly regulated by a number of members which are rarely mutated in tumors. Rather, checkpoint components have been found to be upregulated in aneuploid tumor cells, suggesting a potential tumor “addiction” to SAC functions. MPS1 kinase, (also known as TTK) is an essential SAC enzyme aberrantly overexpressed in a wide range of tumors and necessary for tumor cell proliferation. We previously reported the identification of NMS-P715 as a selective and orally bioavailable MPS1 inhibitor capable of promoting mitotic acceleration, thereby causing aneuploidy and cancer cell death both in vitro and in vivo. Supported by the proof that MPS1 small-molecule inhibitors display the expected mechanism of action and promote tumor growth inhibition in preclinical cancer models, further medicinal chemistry efforts were undertaken and led to the discovery of NMS-P153 as an early candidate product. NMS-P153 is highly selective, and compared to NMS-P715, shows improved in vitro enzymatic potency on MPS1 (IC50 of 3 nM), 10-fold increased mitotic override activity, longer dissociation half-life and better mouse and rat PK parameters, leading to impressive tumor growth inhibition associated with tumor regression in efficacy studies. Proliferation data performed on a large panel of cell lines (&amp;gt;100) have been obtained and will be essential to decipher the most sensitive genetic backgrounds to chemical abrogation of MPS1 function. In addition, single and repeated toxicology studies in rat are being carried out to establish therapeutic safety margins. Inhibiting the spindle assembly checkpoint by targeting MPS1 kinase could represent a promising new approach to cancer therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr B241.
Gram-Positive Pathogens (2019)

specimen handling is emphasised but exact descriptions of smear preparation are not provided.) The final three chapters deal with principles of safe practice, including the role of clinical cytology in patient management, medicolegal considerations, and the contentious issue of the relative merits of fine needle aspiration and core biopsy. The intervening chapters are about specific areas of concern in practice, such as cystic lesions, lymphoid infiltrates and small round cell tumors. It should be apparent that I like this book very much, and it does succeed in its purpose of restating the potential and problems of clinical cytopathology in a way that provides both orientation for the neophyte and advice for the practicing pathologist. Having said that, there are occasional jarring things about it. An inexplicable number of spelling errors are present, including one on the first page! A few sub-standard photomicrographs appear to have been gleaned from other sources, and other photomicrographs seem to be a ‘‘poor fit’’ with the findings described in the text. But these are minor considerations. I intend to have trainees in my institution read the first few chapters several times during their time with the cytology service, and would certainly highly recommend this book to all practicing pathologists having any involvement with cytopathology.
Treatment of obstructive sleep apnoea in Samoa progressively reduces daytime blood pressure over 6 months (2009)

Hypertensive OSA patients can exhibit large falls in BP with CPAP at 1 month, with further significant reductions at 3 and 6 months. Overall, the fall in BP was proportional to the initial elevation of the BP with many patients achieving normal BP at 6 months.
A simple model for tuning tasks (2011)

Modern computer architectures, with multicore CPUs and GPUs or other accelerators, make stronger demands than ever on writers of scientific code. As a rule of thumb, the fastest, most efficient program consists of labor-intensive code written by expert programmers for a certain application on a particular computer. This thesis deals with several algorithmic and technical approaches towards effectively satisfying the demand for high-performance parallel programming without incurring such a high cost in expert programmer time. Effective programming is accomplished by writing performance-portable code where performance-critical functionality is provided either by external software or at least a balance between maintainability/generality and efficiency.
Optical functional devices based on photonic crystals: laser and add-drop devices (2002)

Two optical functional devices based on 2D photonic crystal are investigated. First of all, add-drop filtering devices based on single defects in 2D photonic crystal slabs are characterized. After describing basic characteristics of channel-drop function, we show the improvement of device characteristics through defect engineering. We also demonstrate the channel-add function of the device. Next, we describe a 2D large-area surface-emitting laser exhibiting single-longitudinal and single-lateral mode oscillation with narrow divergence angle based on the 2D coupling effect of lightwave in 2D photonic crystals. A method of controlling the polarization mode by changing the shape of the unit cell is also presented. These results indicate that 2D photonic crystals are useful for the realization of novel optical functional devices.
52500 Characterization of a Series of 1,4-diaryl-pyrazolo-pyridinones as Anti-Leishmanial Agents (2021)

ABSTRACT IMPACT: The first-line chemotherapies used to treat leishmaniasis are highly toxic intravenous antimonials yet drug resistance has begun to develop, causing the use of oral treatment options with high price tags; there is a strong need for new, safe, and effective chemotherapeutic agents to treat leishmaniasis. OBJECTIVES/GOALS: This study was conducted in order to identify novel chemical compounds that exhibit anti-leishmanial activity and to further characterize their efficacy and toxicity in in vitro and in vivo systems in the hopes of future chemotherapeutic developments. METHODS/STUDY POPULATION: A total of 28 unique 1,4-diaryl-pyrazolo-pyridinone (1,4-DAPP) compounds were synthesized and anti-leishmanial efficacy and host cell toxicity were determined using L. donovani mCherry-expressing amastigotes and THP-1 macrophages. Additional pharmacokinetic analyses of a potent 1,4-DAPP compound were conducted, revealing a potential metabolite structure. A select group of the novel compounds were screened in a cutaneous leishmaniasis (CL) murine model using L. major mCherry-expressing parasites and female Balb/C mice. The treatment consisted of 10 intralesional injections of compound over a period of 4 weeks, while lesion growth was monitored via fluorescence and manual measurements. RESULTS/ANTICIPATED RESULTS: Four experimental compounds had IC50 values less than 5 micromolar, providing similar anti-leishmanial activity to Miltefosine. Compound 9279817 had a clearance almost twice the rate of normal hepatic blood flow and had a relatively high volumes of distribution, indicating this compound is rapidly cleared and distributes into tissues. In vitro rat liver microsome assays suggest a rapid metabolism of 9279817 and MS/MS results suggest this metabolite is most likely formed via oxidation of the sulfur on the lower aryl ring. This sulfoxide metabolite has similar efficacy as the parent compound and does not exhibit toxicity in vitro. Three of the experimental compounds behaved similarly to the antimony positive control in the murine CL model. DISCUSSION/SIGNIFICANCE OF FINDINGS: This study revealed a novel structural class of compounds that have anti-leishmanial activity. Experiments show compounds with similar efficacy to Miltefosine while having significantly less cytotoxicity, suggesting that the 1,4-DAPP structural class could be further developed as a potential chemotherapeutic.
Capacity Control of Social Media Diffusion for Real-Time Analysis System (2017)

In Twitter-like services, countless messages are being posted in real-time every second all around the world. Timely knowledge about what kinds of information are diffusing in social media is quite important. For example, in emergency situations such as earthquakes, users provide instant information on their situation through social media. The collective intelligence of social media is useful as a means of information detection complementary to conventional observation. We have developed a system for monitoring and analyzing information diffusion data in real-time by tracking retweeted tweets. A tweet retweeted by many users indicates that they find the content interesting and impactful. Analysts who use this system can find tweets retweeted by many users and identify the key people who are retweeted frequently by many users or who have retweeted tweets about particular topics. However, bursting situations occur when thousands of social media messages are suddenly posted simultaneously, and the lack of machine resources to handle such situations lowers the system's query performance. Since our system is designed to be used interactively in real-time by many analysts, waiting more than one second for a query results is simply not acceptable. To maintain an acceptable query performance, we propose a capacity control method for filtering incoming tweets using extra attribute information from tweets themselves. Conventionally, there is a trade-off between the query performance and the accuracy of the analysis results. We show that the query performance is improved by our proposed method and that our method is better than the existing methods in terms of maintaining query accuracy.
Comment on “Evidence for Quantized Displacement in Macroscopic Nanomechanical Oscillators” (2005)

In a recent Letter, Gaidarzhy et al. [1] claim to have observed evidence for "quantized displacements" of a high-order mode of a nanomechanical oscillator. We contend that the methods employed by the authors are unsuitable in principle to observe such states for any harmonic mode.
Efficient Palladium‐Catalyzed Coupling of Aryl Chlorides and Tosylates with Terminal Alkynes: Use of a Copper Cocatalyst Inhibits the Reaction (2003)

Geringere Katalysatormenge bei niedrigerer Temperatur – dies sind nur zwei der Vorteile der hier vorgestellten Methode zur Pd-katalysierten Kupplung von Arylchloriden mit Alkinen (siehe Schema). Im Unterschied zu etablierten Methoden werden hier nicht nur bessere Ergebnisse ohne Kupfer als Cokatalysator erzielt, sondern Kupfer inhibiert sogar die Produktbildung. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2003/z53015_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Enhancement of Stochastic Resonance Using Optimization Theory (2006)

The traditional stochastic resonance is realized by adding an optimal amount of noise, while the parameter-tuning stochastic resonance is realized by optimally tuning the system parameters. This paper reveals the possibility to further enhance the stochastic resonance effect by tuning system parameters and adding noise at the same time using optimization theory. The further improvement of the maximal normalized power norm of the bistable double-well dynamic system with white Gaussian noise input can be converted to an optimization problem with constraints on system parameters and noise intensity, which is proven to have one and only one local maximum for the Gaussian-distributed weak input signal. This result is then extended to the arbitrary weak input signal case. For the purpose of practical implementation, a fast-converging optimization algorithm to search the optimal system parameters and noise intensity is also proposed. Finally, computer simulations are performed to verify its validity and demonstrate its potential applications in signal processing.
Gene Expression Profiling: Identification of Novel Pathways and Potential Biomarkers in Severe Acute Pancreatitis (2022)

There were significant differences in gene expression affecting the severity of AP, revealing a central role of specific immunological pathways. Despite the existence of patient endotypes, a 4-gene transcriptomic signature (S100A8, S100A9, MMP25, and MT-ND4L) was determined that can predict severe AP with an accuracy of 64%.
Unicompartmental knee replacement (2011)

♦ Ideal treatment option for end-stage osteoarthritis affecting a single compartment of the knee ♦ Unicompartmental knee replacement has many advantages over total knee replacement • Restores near normal kinematics • Usually gives a better range of movement • Patients require a shorter hospital stay • Fewer serious complications