gebhart/patrepeval huggingface dataset:
Effect of electron blocking layer on inter-QW transport in III-nitride multi-QW LEDs (2014)

Strong disparity in electron and hole transport characteristics and excessive depth of optically active quantum wells (QWs) in III-nitride materials are the main causes of inhomogeneous carrier distribution and uneven QW injection in multi-QW light emitters of visible range. Both polar and nonpolar LED structures suffer from inhomogeneous injection. Undoped wide-bandgap electron blocking layer (EBL) located on the P-side of the active region can only make the situation worse by further reducing already insufficient hole injection. On the other hand, P-doped EBL facilitates the hole injection, improves the overall active region injection uniformity, and reduces the carrier leakage. We show, however, that EBLs act very differently in polar and nonpolar III-nitride multi-QW structures. While in nonpolar LED the p-doped EBL ultimately promotes the inter-QW carrier exchange, the injection efficiency in polar structure remains limited by strong electron leakage from the marginal p-side QW.
Sex hormonal regulation and hormesis in aging and longevity: role of vitagenes (2014)

Aging process is accompanied by hormonal changes characterized by an imbalance between catabolic hormones, such as cortisol and thyroid hormones which remain stable and hormones with anabolic effects (testosterone, insulin like growth factor-1 (IGF-1) and dehydroepiandrosterone sulphate (DHEAS), that decrease with age. Deficiencies in multiple anabolic hormones have been shown to predict health status and longevity in older persons.Unlike female menopause, which is accompanied by an abrupt and permanent cessation of ovarian function (both folliculogenesis and estradiol production), male aging does not result in either cessation of testosterone production nor infertility. Although the circulating serum testosterone concentration does decline with aging, in most men this decrease is small, resulting in levels that are generally within the normal range. Hormone therapy (HT) trials have caused both apprehension and confusion about the overall risks and benefits associated with HT treatment. Stress-response hormesis from a molecular genetic perspective corresponds to the induction by stressors of an adaptive, defensive response, particularly through alteration of gene expression. Increased longevity can be associated with greater resistance to a range of stressors. During aging, a gradual decline in potency of the heat shock response occur and this may prevent repair of protein damage. Conversely, thermal stress or pharmacological agents capable of inducing stress responses, by promoting increased expression of heat-shock proteins, confer protection against denaturation of proteins and restoration of proteome function. If induction of stress resistance increases life span and hormesis induces stress resistance, hormesis most likely result in increased life span. Hormesis describes an adaptive response to continuous cellular stresses, representing a phenomenon where exposure to a mild stressor confers resistance to subsequent, otherwise harmful, conditions of increased stress. This biphasic dose-response relationship, displaying low-dose stimulation and a high-dose inhibition, as adaptive response to detrimental lifestyle factors determines the extent of protection from progression to metabolic diseases such as diabetes and more in general to hormonal dysregulation and age-related pathologies. Integrated responses exist to detect and control diverse forms of stress. This is accomplished by a complex network of the so-called longevity assurance processes, which are composed of several genes termed vitagenes. Vitagenes encode for heat shock proteins (Hsps), thioredoxin and sirtuin protein systems. Nutritional antioxidants, have recently been demonstrated to be neuroprotective through the activation of hormetic pathways under control of Vitagene protein network. Here we focus on possible signaling mechanisms involved in the activation of vitagenes resulting in enhanced defense against functional defects leading to degeneration and cell death with consequent impact on longevity processes.
The effect of transient needle lift on the internal flow and near-nozzle spray characteristics for modern GDI systems investigated by high-speed X-ray imaging (2021)

The development of the injector nozzle is a dynamic area in regard of several technical aspects. At first, the internal flow influences the near-field spray characteristics via various phenomena such as cavitation and turbulence. However, these phenomena are not fully understood due to their extremely fast, complex and multiscale nature. Furthermore, it governs the spray targeting inside the combustion chamber. High-speed X-ray imaging of GDI injector nozzles is performed in this study. The experimental results presented are related to the internal flow and primary breakup of discharged liquid jets. The injectors used are equipped with nozzles made of aluminum which have been specially developed for these investigations to enhance optical accessibility. The visualization of the needle motion, in-nozzle flow and the primary breakup region provides several exciting observations. First, the needle lift tracking exhibits short overshooting right before the steady-state of the injection phase. This event leads to a short-term, however, significant change in the associated performance of the breakup. This phenomenon is found to be a consequence of the transient behavior of the in-nozzle flow. It is shown that under some circumstances hydraulic flip may occur during this overshooting period. The primary jet breakup region is visualized and evaluated by means of image processing. Thus, the transient behavior of liquid jet expansion is quantified in the vicinity of the nozzle. It is observed that the liquid jet direction deviates from the hole axis already at the nozzle outlet, which is caused by internal flow characteristics.
Chain-Growth Polymerization of Unusual Anion-Radical Monomers Based on Naphthalene Diimide: A New Route to Well-Defined n-Type Conjugated Copolymers (2011)

Strongly electron-deficient (n-type) main-chain π-conjugated polymers are commonly prepared via well-established step-growth polycondensation protocols which enable limited control over polymerization. Here we demonstrate that activated Zn and electron-deficient brominated thiophene-naphthalene diimide oligomers form anion-radical complexes instead of conventional Zn-organic derivatives. These highly unusual zinc complexes undergo Ni-catalyzed chain-growth polymerization leading to n-type conjugated polymers with controlled molecular weight, relatively narrow polydispersities, and specific end-functions.
Two-Dimensional High-Performance Liquid Chromatography Using Monodisperse Polymer Beads Containing Segregated Chemistries Prepared by Pore Size Specific Functionalization. Single-Column Combinations of Size Exclusion or Ion Exchange with Reversed-Phase Chromatography (1994)

Separation media for the complete separation of complex samples that require a combination of size exclusion or ion-exchange with reversed-phase chromatographic modes in a single column have been prepared from size monodisperse 10 microns poly(glycidyl methacrylate-co-ethylene dimethacrylate) beads using a pore size specific functionalization process. To achieve the first combination of chromatographic modes, the large pores of the beads were selectively hydrolyzed to diols using aqueous poly(styrenesulfonic acid), while highly hydrophobic octadecyl groups were introduced into the small pores by reaction of the remaining epoxide groups with octadecylamine. These beads provide excellent protein recoveries and may be used for the direct injection separation of samples containing both hydrophilic proteins and hydrophobic drugs. Beads containing diethylamino groups in the large pores and octadecyl functionalities in the small pores were also prepared by size-selective modification. A plot of log k' against ionic strength of the mobile phase for these beads shows the absence of hydrophobic interactions and documents the clean ion-exchange mechanism of protein separation. Examination of the small pores in both types of separation media confirmed that their hydrophobicity was sufficient to allow the separations of small molecules in reversed-phase mode. Column packed with these dual-chemistry beads exhibited high efficiencies and were used successfully for the separations of proteins and alkylbenzenes or drugs.
On the Duality and Difference Between Slepian-Wolf Coding and Channel Coding (2007)

The duality between the sphere packing exponents, random coding exponents, and correct decoding exponents for Slepian-Wolf coding and channel coding is established. A systematic analysis and comparison of the expurgated exponents for Slepian-Wolf coding and channel coding is provided. This analysis, in conjunction with the linear codebook-level duality between Slepian-Wolf coding and channel coding, reveals that nonlinear Slepian-Wolf codes can strictly outperform linear Slepian-Wolf codes in terms of rate-error tradeoff at high rates.
A global assembly of cotton ESTs (2006)

Approximately 185,000 Gossypium EST sequences comprising >94,800,000 nucleotides were amassed from 30 cDNA libraries constructed from a variety of tissues and organs under a range of conditions, including drought stress and pathogen challenges. These libraries were derived from allopolyploid cotton (Gossypium hirsutum; A(T) and D(T) genomes) as well as its two diploid progenitors, Gossypium arboreum (A genome) and Gossypium raimondii (D genome). ESTs were assembled using the Program for Assembling and Viewing ESTs (PAVE), resulting in 22,030 contigs and 29,077 singletons (51,107 unigenes). Further comparisons among the singletons and contigs led to recognition of 33,665 exemplar sequences that represent a nonredundant set of putative Gossypium genes containing partial or full-length coding regions and usually one or two UTRs. The assembly, along with their UniProt BLASTX hits, GO annotation, and Pfam analysis results, are freely accessible as a public resource for cotton genomics. Because ESTs from diploid and allotetraploid Gossypium were combined in a single assembly, we were in many cases able to bioinformatically distinguish duplicated genes in allotetraploid cotton and assign them to either the A or D genome. The assembly and associated information provide a framework for future investigation of cotton functional and evolutionary genomics.
Variations in the Myocilin Gene in Patients With Open-Angle Glaucoma (2002)

Testing for the MYOC.mt1 promoter polymorphism appears to be of no value in the evaluation of patients with glaucoma.
Effects of tracking technology, latency, and spatial jitter on object movement (2009)

We investigate the effects of input device latency and spatial jitter on 2D pointing tasks and 3D object movement tasks. First, we characterize jitter and latency in a 3D tracking device and an optical mouse used as a baseline comparison. We then present an experiment based on ISO 9241-9, which measures performance characteristics of pointing devices. We artificially introduce latency and jitter to the mouse and compared the results to the 3D tracker. Results indicate that latency has a much stronger effect on human performance than low amounts of spatial jitter. In a second study, we use a subset of conditions from the first to test latency and jitter on 3D object movement. The results indicate that large, uncharacterized jitter “spikes” significantly impact 3D performance.
Supplementary Data from Development of Highly Effective Anti-Mesothelin hYP218 Chimeric Antigen Receptor T Cells With Increased Tumor Infiltration and Persistence for Treating Solid Tumors (2023)

Supplementary Data from Development of Highly Effective Anti-Mesothelin hYP218 Chimeric Antigen Receptor T Cells With Increased Tumor Infiltration and Persistence for Treating Solid Tumors
Predictors of pain and use of pain medications following primary Total Hip Arthroplasty (THA): 5,707 THAs at 2-years and 3,289 THAs at 5-years (2010)

Higher BMI and depression impacted moderate-severe pain; and female gender, higher BMI and depression predicted use of pain medications at 2- and 5-years post-primary THA.
Hydrogen‐Driven Collapse of C60 Inside Single‐Walled Carbon Nanotubes (2012)

Ein kleiner Eindringling: Die Reaktion von C60 mit Wasserstoff im Inneren von Kohlenstoffnanoröhren wurde bei erhöhtem Druck und erhöhter Temperatur untersucht und mit der Reaktion von C60-Pulver verglichen. Oberhalb 500 °C wurde der Zerfall der Fullerenkäfige unter Bildung von Kohlenwasserstoffen beobachtet. Es wurde direkt bewiesen, dass Wasserstoff in die Nanoröhren eindringt und dort mit den Fullerenen reagiert (siehe Bild). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Positively Charged Termini of the L2 Minor Capsid Protein Are Necessary for Papillomavirus Infection (2001)

Coexpression of bovine papillomavirus L1 with L2 mutants lacking either eight N-terminal or nine C-terminal amino acids that encode positively charged domains resulted in wild-type levels of viral genome encapsidation. Despite wild-type binding to the cell surface, the resulting virions were noninfectious. An L2 mutant encoding a scrambled version of the nine C-terminal residues restored infectivity, in contrast to an L2 mutant encoding a scrambled version of the N-terminal residues.
Thrombospondin binds to Staphylococcus aureus and promotes staphylococcal adherence to surfaces (1991)

Bacterial adherence to surfaces is the determining first step in staphylococcal infections. Activated platelets mediate adherence of staphylococci to tissues during inflammation or infection; however, the molecular mechanisms of this interaction are not clearly understood. Thrombospondin, a large multifunctional glycoprotein, is the principal platelet-stored glycoprotein. It is secreted upon platelet activation and either bound to receptors on the platelet surface or released and incorporated into blood clots and extracellular matrices. To characterize thrombospondin binding to staphylococci, we incubated [125I]thrombospondin with Staphylococcus aureus Cowan 1 in the presence of albumin and separated bound and free thrombospondin by centrifugation. We found that binding was (i) specific, since it was up to 76% inhibitable and up to 60% reversible in the presence of a 100-fold excess of unlabeled thrombospondin, (ii) saturable, with an apparent dissociation constant (Kd) of 5.6 x 10(-9) M and a maximal number of 2,600 binding sites per microorganism, and (iii) Ca2+ dependent, since omission of this ion from the medium decreased significantly the binding capacity. The binding reaction was insensitive to previous trypsin treatment of bacteria, but it was strongly inhibited in the presence of heparin. Protein A-negative and -positive strains had similar binding characteristics. To determine the promotion of staphylococcal adherence to surfaces by solid-phase thrombospondin, we incubated 3H-labeled S. aureus Cowan 1 and 26 pathogenic staphylococcal isolates with thrombospondin-coated polymethylmethacrylate disks and found that adherence was significantly promoted as a function of adsorbed thrombospondin. These results indicate a role for thrombospondin as an important mediator of staphylococcal adherence to activated platelets, to blood clots, or to extracellular matrices in pyogenic infections.
Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300 (2012)

K.o. für den Coaktivator: Die Naturstoffe Sekikasäure und Lobarsäure wurden über ein Hochdurchsatz-Screening einer strukturell diversen Extraktsammlung isoliert. Sie wechselwirken effizient mit den dynamischen Bindungsbereichen der GACKIX-Domäne des Coaktivators CBP/p300 (siehe Struktur) und sind damit die wirksamsten und selektivsten bisher bekannten Inhibitoren der GACKIX-Domäne.
Evolution of host protease interactions among SARS-CoV-2 variants of concern and related coronaviruses (2022)

Previously, we showed that coagulation factors directly cleave SARS-CoV-2 spike and promote viral entry (Kastenhuber et al., 2022). Here, we show that substitutions in the S1/S2 cleavage site observed in SARS-CoV-2 variants of concern (VOCs) exhibit divergent interactions with host proteases, including factor Xa and furin. Nafamostat remains effective to block coagulation factor-mediated cleavage of variant spike sequences. Furthermore, host protease usage has likely been a selection pressure throughout coronavirus evolution, and we observe convergence of distantly related coronaviruses to attain common host protease interactions, including coagulation factors. Interpretation of genomic surveillance of emerging SARS-CoV-2 variants and future zoonotic spillover is supported by functional characterization of recurrent emerging features.
Surface Modification and Drug Delivery for Biointegration (2011)

Biointegration refers to the interconnection between a biomedical device and the recipient tissue. In many implant devices, the lack of proper biointegration can cause device failure and potentially serious medical problems. This review summarizes the recent progress in surface chemistry, drug delivery and antifouling methods to improve the biointegration of implants. Much progress has been made as our understanding of biological systems and material properties expands and as new technologies become available. This article addresses methods of enhancing biointegration by means of modifying implant surface chemistry and by drug-delivery approaches.
Sparse Code Multiple Access for 5G Radio Transmission (2017)

Non-orthogonal multiple access has been extensively discussed in New Radio (NR), the study item working on 5G air interface in 3GPP. Sparse code multiple access (SCMA) is one of the proposed MA schemes. In this paper, the basic concept of SCMA is introduced, including codebook mapping, multiple access procedure, and advanced receivers. Then, link level simulations are applied to verify the design of SCMA, which show that SCMA has many excellent properties: shaping and diversity gain by sparse codebooks, resilient to inter- user interference, and robust to codebook collision, thus it is a promising candidate MA scheme for 5G.
Revisiting iterative time reversal processing: Application to detection of multiple targets (2004)

The iterative time reversal processing represents a high speed and easy way to self-focus on the strongest scatterer in a multitarget medium. However, finding weaker scatterers is a more difficult task that can be solved by computing the eigenvalue and eigenvector decomposition of the time reversal operator, the so-called DORT method. Nevertheless, as it requires the measurement of the complete interelements response matrix and time-consuming computation, the separation of multiple targets may not be achieved in real time. In this study, a new real time technique is proposed for multitarget selective focusing that does not require the experimental acquisition of the time reversal operator. This technique achieves the operator decomposition using a particular sequence of filtered waves propagation instead of computational power. Due to its simplicity of implementation, this iterative process can be achieved in real time. This high speed selective focusing is experimentally demonstrated by detecting targets through a heterogeneous medium and in a speckle environment. A theoretical analysis compares this technique to the DORT formalism.
A phase 1/2 study of REGN4336, a PSMAxCD3 bispecific antibody, alone and in combination with cemiplimab in patients with metastatic castration-resistant prostate cancer. (2023)

TPS284 Background: Prostate cancer is the leading cause of new cancer diagnoses and the second most common cause of cancer-related death in American men. Prognosis is especially poor for men with metastatic castration resistant prostate cancer (mCRPC). Prostate-specific membrane antigen (PSMA) is highly expressed on malignant prostate tissue but shows limited expression on normal tissue. As such, PSMA is an excellent research target for treatment of mCRPC. REGN4336 is a PSMAxCD3 bispecific antibody designed to facilitate T-cell–mediated killing of PSMA-expressing tumor cells. In preclinical models, REGN4336 demonstrated strong PSMA-dependent antitumor activity that was dose-dependent. Preclinical data also support clinical research into the combination of REGN4336 with cemiplimab (anti–programmed cell death-1) for treating mCRPC. Methods: This is an open-label, Phase 1/2, first-in-human, multicenter dose-escalation study with dose expansion evaluating safety, tolerability, pharmacokinetics (PK), and antitumor activity of REGN4336 administered subcutaneously alone and in combination with intravenous cemiplimab in patients with mCRPC (NCT05125016). Patients must have received at least two prior lines of systemic therapy approved for metastatic and/or castration-resistant disease including a second-generation anti-androgen therapy. In Module 1, REGN4336 as monotherapy is administered weekly but may be extended to once every 3 weeks following identification of the minimal pharmacologically active dose. In Module 2, REGN4336 will be administered in combination with cemiplimab (350 mg) once every 3 weeks after a 4-week REGN4336 monotherapy lead-in cycle. Study therapies are administered until disease progression, intolerable adverse events, withdrawal of consent, or a study withdrawal criterion is met. The primary objectives in dose escalation are to evaluate the safety, tolerability, PK, and recommended phase 2 dosing regimen (RP2DR) of REGN4336 alone and in-combination with cemiplimab. Expansion cohort(s) will be enrolled once RP2DRs have been determined. During the expansion phase, the primary objective is to assess clinical activity, as measured by objective response rate with REGN4336 alone or in combination with cemiplimab per modified Prostate Cancer Working Group 3 criteria. At selected sites, PSMA positron emission tomography/computed tomography scans will be performed at predefined timepoints on study. This study is currently open to enrollment. Clinical trial information: NCT03088540 .
Lighting Studies for Fuelling Machine Deployed Visual Inspection Tool (2015)

Under subcontract to James Fisher Nuclear, Ltd., INL has been reviewing advanced vision systems for inspection of graphite in high radiation, high temperature, and high pressure environments. INL has performed calculations and proof-of-principle measurements of optics and lighting techniques to be considered for visual inspection of graphite fuel channels in AGR reactors in UK.