gebhart/patrepeval huggingface dataset:
Equilibrium constants for thiol-disulfide interchange reactions: a coherent, corrected set (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEquilibrium constants for thiol-disulfide interchange reactions: a coherent, corrected setWatson J. Lees and George M. WhitesidesCite this: J. Org. Chem. 1993, 58, 3, 642–647Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/jo00055a016https://doi.org/10.1021/jo00055a016research-articleACS PublicationsRequest reuse permissionsArticle Views1730Altmetric-Citations166LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chemical Modification of Carbon Nanotubes (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Pressure and temperature‐based adaptive observer of air charge for turbocharged diesel engines (2004)

Abstract In this paper we design an adaptive air charge estimator for turbocharged diesel engines using intake manifold pressure, temperature and engine speed measurements. This adaptive observer scheme does not depend on mass air flow sensors and can be applied to diesel engines with no exhaust gas recirculation (EGR). The performance of the adaptive scheme is shown in simulations to be comparable to conventional air charge estimation schemes if perfect temperature measurements are available. The designed scheme cannot estimate fast transients and its performance deteriorates with temperature sensor lags. Despite all these difficulties, this paper demonstrates that (i) the proposed scheme has better robustness to modelling errors because it provides a closed‐loop observer design, and (ii) robust air charge estimation is achievable even without air flow sensors if good (fast) temperature sensors become available. Finally, we provide a rigorous proof and present the implementation challenges as well as the limiting factors of this adaptation scheme and point to hardware and temperature sensor requirements. Copyright © 2004 John Wiley &amp; Sons, Ltd.
Geste Médico-Chirurgical Assisté Par Ordinateur - Application à La Visée Automatisée Du Pédicule Vertébral (1995)

"Geste Médico-Chirurgical Assisté Par Ordinateur - Application à La Visée Automatisée Du Pédicule Vertébral." Archives of Physiology and Biochemistry, 103(3), p. C123
Cytokine-mediated induction of endothelial adhesion molecule and histocompatibility leukocyte antigen expression by cytomegalovirus-activated T cells. (1996)

Cytomegalovirus (CMV) has been associated with allograft rejection and transplantation-associated arteriosclerosis. CMV infects endothelium, the interface between allograft tissue and the host immune system; however, mechanisms by which such interaction might exacerbate the rejection process remain unresolved. Here we test the hypothesis that host immune activity, triggered by CMV-infected graft endothelial cells (ECs), can result in the production of cytokines capable of enhancing the alloimmunogenicity of nearby uninfected endothelia. To model these phenomena in vitro, confluent monolayers of ECs derived from human umbilical vein or adult gonadal vein were incubated 5 days beneath trans-well culture inserts containing CMV-seropositive or CMV-seronegative donor-derived CD3+ or CD4+ T cells alone or in combination with CMV-infected or uninfected allogeneic ECs. The extent of T cell proliferation was determined by [3H]thymidine labeling of trans-well contents after transfer to microtiter plates. Endothelial responses to soluble factors elaborated by CMV-activated T cells were determined by immunohistochemical staining and immunofluorescence flow cytometric analysis of underlying EC monolayers. Results of experiments with CMV-seropositive donor-derived CD4+ T cells demonstrated enhancement of ICAM-1 and histocompatibility leukocyte antigen class I, as well as induction of histocompatibility leukocyte antigen DR on ECs incubated beneath T cell/EC/CMV trans-well co-cultures. Total (CD3+) T cells co-cultured with EC/CMV induced VCAM-1 as well. Furthermore, [3H]thymidine incorporation by these T cells indicated a strong proliferative response. Endothelial responses to T cells alone or in combination with uninfected ECs were minimal, and T cells cultured under these conditions showed little proliferative activity. Similarly, little or no endothelial responses were apparent in monolayers beneath trans-wells containing T cells isolated from CMV-seronegative individuals regardless of the CMV status of stimulator ECs. Finally, experiments employing blocking antibodies identified interferon-gamma and tumor necrosis factor-alpha as inducing agents in this co-culture system. These findings suggest that allograft endothelium harboring CMV has the potential to activate host T cells and that the consequent release of cytokines shows potential to raise surrounding endothelia to a fully activated, highly immunogenic state. Results of these studies thus provide insight into mechanisms that help elucidate the association between CMV and transplantation-associated arteriosclerosis and/or allograft rejection.
Discovery of the extracytoplasmic function σ factors (2019)

This special issue of Molecular Microbiology marks the 25<sup>th</sup> anniversary of the discovery of the extracytoplasmic function (ECF) σ factors, proteins that subsequently emerged as the largest group of alternative σ factors and one of the three major pillars of signal transduction in bacteria, alongside one- and two-component systems. A single bacterial genome can encode > 100 ECF σ factors, and combined with their cognate anti-σ factors, they represent a modular design that primarily functions in transmembrane signal transduction. Here, we first describe the immediate events that led to the 1994 publication in the Proceeding of the National Academy of Sciences USA, and then set them in the broader context of key events in the history of σ biology research.
Marketing Concept and Customer Orientation (1986)

Examines the marketing concept (MC) and its foundation of customer orientation. Proposes that the General Electric Company promulgated MC and that this followed the Second World War, before being accepted formally by academics. States that the two major concepts are: that consumers know what they want; and that consumer sovereignty prevails. Believes marketers cannot take consumers as a given nor take them for granted and neither can manufacturers or they will also suffer. Questions whether consumers are always informed about products and what exactly they require and whether firms see themselves as merely responding to the market flow. States, in conclusion, that marketing communications can help shape wants and beliefs and that marketers should aim their best efforts at this area to enable better contacts.
Hybrid de novo genome assembly and centromere characterization of the gray mouse lemur (Microcebus murinus) (2017)

We describe a new assembly of the gray mouse lemur (Microcebus murinus) genome with chromosome-scale scaffolds produced using a hybrid bioinformatic and sequencing approach. The approach is cost effective and produces superior results based on metrics of contiguity and completeness. Our results show that emerging genomic technologies can be used in combination to characterize centromeres of non-model species and to produce accurate de novo chromosome-scale genome assemblies of complex mammalian genomes.
Breaking the Loss Limitation of On-chip High-confinement Resonators (2016)

On-chip optical resonators have the promise of revolutionizing numerous fields including metrology and sensing; however, their optical losses have always lagged behind their larger discrete resonator counterparts based on crystalline materials and flowable glass. Silicon nitride (Si3N4) ring resonators open up capabilities for optical routing, frequency comb generation, optical clocks and high precision sensing on an integrated platform. However, simultaneously achieving high quality factor and high confinement in Si3N4 (critical for nonlinear processes for example) remains a challenge. Here, we show that addressing surface roughness enables us to overcome the loss limitations and achieve high-confinement, on-chip ring resonators with a quality factor (Q) of 37 million for a ring with 2.5 μm width and 67 million for a ring with 10 μm width. We show a clear systematic path for achieving these high quality factors. Furthermore, we extract the loss limited by the material absorption in our films to be 0.13 dB/m, which corresponds to an absorption limited Q of at least 170 million by comparing two resonators with different degrees of confinement. Our work provides a chip-scale platform for applications such as ultra-low power frequency comb generation, high precision sensing, laser stabilization and sideband resolved optomechanics.
Tunable Non-Volatile Analog Resistive Memory and Its Application in AI (2020)

This paper presents a novel analog resistive random-access memory (RRAM), named NeuroMem, which consists of Au/GO/Au. The device's resistance can be tuned to any value within its R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OFF</sub> to R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> range with high precision. The analog characteristic of NeuroMem mimics the memorization behavior of the brain, which makes it great asset for artificial neural network applications. In this work, NeuroMem-based crossbars are fabricated to hold the synaptic weights needed to perform Iris classification. The weight values are mapped to conductance states within NeuroMem R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OFF</sub> to R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> range, and then written accurately on the actual devices. Unlike other RRAM-based hardware with limited conductance states, in this work no quantization is needed which enables efficient in memory-computing without scarifying accuracy. Furthermore, Neuromem device has been demonstrated in crossbars on flexible polymer substrate using standard photolithography process, which facilitates producing low cost flexible electronics. This work opens up great insights towards realizing RRAM-based computing at the edge.
Unified messaging-A value-creating engine for next-generation network services (2002)

Unified messaging provides seamless creation of, notification of, access to, and administration of all message types in different formats using a variety of access devices. It supports voice mail, e-mail, and fax messages in text, data, and binary formats. The access devices that carry unified messaging include the telephone, computer, personal digital assistant, and wireless handset. To be successful in network operations, a unified messaging system must satisfy the needs of both service providers and end users. The AnyPath Unified Messaging System, currently under development, is designed to meet all these needs along six dimensions. It offers the reliability and scalability required to support carrier-grade service, an intelligent networking (IN) capability to support the advanced functionality of the system, and seamless messaging across disparate networks and geographical entities. AnyPath's messaging services can bridge various types of messaging systems, administered by either the service provider or the end user, and personalize them down to the end-user level. The system also meets the financial goals of service providers by generating revenue and using investment protection methods. AnyPath achieves its six design goals while adhering to industry standards and leveraging best-in-class system components.
Incumbent User Active Area Detection for Licensed Shared Access (2015)

Licensed Shared Access is a European standardisation effort which promotes repository based quasi-static hierarchical spectrum sharing. In this scheme the sharing time base is in the order of months if not years. For widespread use of Licensed Shared Access, shrinking the sharing time base is crucial. In this paper we propose a scheme to reduce the sharing time base to seconds or minutes scale. We present a new technique named lightweight Radio Environment Map based on a Kalman Filter derived from geo-location aware spectrum measurements, which can be run at the shared access licensee end. Our objective is to determine the active area of a static or slowly moving incumbent. We consider a challenging scenario where a large fraction of measurements is missing and the available measurements are highly distorted. Performance of our incumbent active area detection approach is evaluated by simulating a low power incumbent in an urban cellular environment. Simulation results show a substantial improvement of missed detection area in comparison to the counterpart that does not use our lightweight Radio Environment Map.
Femtosecond laser filament-assisted AgI-type pyrotechnic nucleant-induced water condensation in cloud chamber (2018)

AgI-type pyrotechnics are widely used in the field of weather modification, as a kind of artificial ice nuclei. However, their precipitation yield remains an intensively studied area. In this paper, we present a study of AgI-type pyrotechnic nucleant-induced water condensation promoted by femtosecond laser filaments in a cloud chamber. It is found that when 50-ml sample was irradiated by the laser filaments, the particles condensed on the glass slide are more soluble and slightly larger (5-15 μm). The irradiation of the laser filament on the nucleant rarely induces the generation of particles of sizes larger than 1 μm; however, it increases the decay time of particles from 13 to 18 min by the creation of numerous small particles. The amount of snow on the cold bottom plate increases by 4.2-13.1% in 2 h, compared to that without the irradiation of the laser filament. These results are associated with the production of high-concentration HNO<sub>3</sub> by the laser filament. The concentration of HNO<sub>3</sub> in the melt water increases by more than ten times when the sample was irradiated by the laser filaments.
The dynamics of image processing viewed as deformation of elastic sheet (2009)

Diffusion-type algorithms have been integrated successfully into the toolbox used in image processing and computer vision. We introduce in the context of digital signal and image processing a new more flexible and powerful family of parabolic-hyperbolic partial differential equations (PDEs) that somewhat resembles the structure of the parabolic diffusion equation, but incorporates the second order derivative in time. It is instructive intuitively to consider in this context the dynamics of image processing as the deformation of an dasiaelastic sheetpsila. Indeed, our parabolic-hyperbolic PDE models elastic deformation. This analogy between a well-known physical system and process on one hand, and the dynamics of an image processing scheme on the other hand, contributes interesting and important insight about images and their processing. We explore and demonstrate the capabilities and advantages afforded by the application of the proposed family of equations in image enhancement. Efficient numeric schemes are also presented.
The structure and location of SIMP/STT3B account for its prominent imprint on the MHC I immunopeptidome (2005)

Proteins show drastic discrepancies in their contribution to the collection of self-peptides that shape the repertoire of CD8 T cells (MHC I self-immunopeptidome). To decipher why selected proteins are the foremost sources of MHC I-associated self-peptides, we chose to study SIMP/STT3B because this protein generates very high amounts of MHC I-associated peptides in mice and humans. We show that the endoplasmic reticulum (ER)-associated degradation pathway and MHC I processing intersect at SIMP/STT3B. Relevant key features of SIMP/STT3B are its lysine-rich region, its propensity to misfold and its location in the ER membrane in close proximity to the immunoproteasome. Moreover, we show that coupling to SIMP/STT3B can be used to foster MHC I presentation of a selected peptide, here the ovalbumin peptide SIINFEKL. These data yield novel insights into relations between the cell proteome and the MHC I immunopeptidome. They suggest that the contribution of a given protein to the MHC I immunopeptidome results from the interplay of at least three factors: the presence of degrons (degradation signals), the tendency of the protein to misfold and its subcellular localization. Furthermore, they indicate that substrates of the ER-associated degradation pathway may have a prominent imprint on the MHC I self-immunopeptidome.
Supplementary Table1 from Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma (2023)

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Microbial Stimulation of Onion Maggot1Oviposition2 (1981)

Ovipositing adults of the onion maggot, Hylemya antiqua (Meigen) (Diptera: Anthomyiidae); laid fewer eggs on sterilized onion seedlings than on either untreated plants or on sterilized plants reinoculated with a mixture of microorganisms taken from healthy seedlings. Reinoculation with Pseudomonas cepacia , a bacterium known to protect onion seedlings from certain fungal pathogens, did not enhance oviposition. Microbes grown on sterile agar media stimulated egg laying only if the substrate contained macerated onion tissue. Thus microorganisms may metabolize chemical precursors in onions and convert them to volatile, stimulatory compounds.
Treatment of nonalcoholic steatohepatitis with probiotics. A proof-of-concept study (2013)

Probiotics treatment may reduce liver fat and AST level in NASH patients. The therapeutic potential of probiotics in NASH should be tested in larger studies.
Aluminum substitution for vanadium in the Na3V2(PO4)2F3 and Na3V2(PO4)2FO2 type materials (2019)

Among the positive electrode materials for Na-ion batteries, Na3V2(PO4)2F3 is considered as one of the most promising and generates high interest. Here, we study the influence of the sol-gel synthesis parameters on the structure and on the electrochemical signature of the partially substituted Na3V2-zAlz(PO4)2(F,O)3 materials. We demonstrate that the acidity of the starting solution influences the vanadium oxidation state of the final product. For the first time we report on the possibility of controlling the double Al/V and O/F substitution that leads to the preparation of the Na3V2-zAlz(PO4)2F1+zO2-z solid solution.
Electromechanical Resynchronization with High Energy Septal Pacing (2016)

Background: Standard cardiac pacing in the right ventricular apex alters electrical synchrony generating left bundle branch block that in some cases causes mechanical dyssynchrony. Pacing taking into account the anatomy (septal pacing) and with enough energy to narrow the QRS complex could have a beneficial effect, improving electrical and mechanical synchrony,and consequently myocardial function.Objective: The aim of this study was to evaluate acute electrical, mechanical and hemodynamic behavior in patients with severe intraventricular conduction disorders treated with high-energy septal pacing, and compare it with other pacing sites in the right ventricle (apex and outflow tract).Methods: Thirty patients whose average age was 65 years were continuously analyzed. They were divided into: Group I (n=15) with severe conduction disorders, complete left bundle branch block or complete right bundle branch block associated with left anterior hemiblock, all with dilated cardiomyopathy and ejection fraction (EF) <35%, and Group II (n=15) without conduction disorders and preserved EF.All patients underwent an electrophysiological study where the following parameters were evaluated in the acute phase: QRS duration in ms, time between the onset of surface QRS or spike and the most distal sites of the basal left ventricular (LV) wall, measured in the coronary sinus (R-LV), isovolumic contraction time (ICT) and ejection fraction measured by tissue Doppler echocardiography (performed off-line by an echocardiography specialist) and LV dP/dtmax assessed with an intracardiac Millar catheter (only in 18 cases). All these variables were evaluated at baseline (without pacing), with high energy septal pacing (7.5 V and 1 ms pulse width), and with right ventricular apical and outflow tract pacing. High energy pacing was used to evaluate the thresholds for QRS “narrowing”.Results: In Group I, QRS, R-LV and isovolumic contraction times improved with high energy septal pacing, but not with pacing in other sites, even with improved EF. Conversely, in Group II without conduction disorders, high energy septal pacing did not prolong QRS, R-LV or isovolumic contraction times, nor improved EF, but these parameters increased with pacing in other sites.Left ventricular dP/dtmax showed an average increase of 14% in 16 of the 18 patients evaluated in the acute phase.Conclusions: In patients with severe conduction disorders and low ejection fraction (EF), septal pacing allows electromechanical resynchronization with improved EF and dP/dtmax. In patients without conduction disturbances, this septal pacing does not modify electrical synchrony while pacing in other sites such as the right ventricular apex and outflow tract impairs it.
In Search of Covariates of HIV-1 Subtype B Spread in the United States—A Cautionary Tale of Large-Scale Bayesian Phylogeography (2020)

Infections with HIV-1 group M subtype B viruses account for the majority of the HIV epidemic in the Western world. Phylogeographic studies have placed the introduction of subtype B in the United States in New York around 1970, where it grew into a major source of spread. Currently, it is estimated that over one million people are living with HIV in the US and that most are infected with subtype B variants. Here, we aim to identify the drivers of HIV-1 subtype B dispersal in the United States by analyzing a collection of 23,588 <i>p</i>ol sequences, collected for drug resistance testing from 45 states during 2004-2011. To this end, we introduce a workflow to reduce this large collection of data to more computationally-manageable sample sizes and apply the BEAST framework to test which covariates associate with the spread of HIV-1 across state borders. Our results show that we are able to consistently identify certain predictors of spread under reasonable run times across datasets of up to 10,000 sequences. However, the general lack of phylogenetic structure and the high uncertainty associated with HIV trees make it difficult to interpret the epidemiological relevance of the drivers of spread we are able to identify. While the workflow we present here could be applied to other virus datasets of a similar scale, the characteristic star-like shape of HIV-1 phylogenies poses a serious obstacle to reconstructing a detailed evolutionary and spatial history for HIV-1 subtype B in the US.