gebhart/patrepeval huggingface dataset:
Prevention strategies for antimicrobial resistance: a systematic review of the literature (2010)

Antibiotics offer great benefits by reducing the duration and severity of illnesses and aiding in infection transmission control. With this being said, the inexorable process of antimicrobial drug resistance is to some degree unavoidable. Although drug resistance will likely persist and is to be expected, the overall level can be dramatically decreased with increased attention to antibiotic overuse and the pharmacokinetic and pharmacodynamic properties of different drug formulations, and the use of proper hygiene and protective barriers. Implementation of such practices as microbial surveillance and prophylaxis has been shown to result in decreased hospital length of stay, health care costs and mortality due to drug-resistant infections. This review will summarize current progress in preventative techniques aimed at reducing the incidence of infection by antimicrobial-resistant bacteria and the emergence and spread of antimicrobial-resistant strains. By employing a variety of prevention strategies, including proper personal hygiene, prescreening for carrier status before hospital admission, disinfection of hospital rooms, and careful monitoring of antimicrobial prescribing, marked progress can be achieved in the control of drug-resistant pathogens, which can translate into more effective antimicrobial therapy.
Real-time increase in depth of field of an uncooled thermal camera using several phase-mask technologies (2011)

International audience
S-band Amplifiers and Tunable Lasers with Thulium-Doped Fluoride Fiber (2002)

We demonstrated S-band tunable thulium-doped fiber ring laser with a tuning range of 90 nm and linewidth of 300 MHz. Experimental results for thulium-doped optical amplifiers and ASE for different pump schemes are also discussed
Sea of leads (SoL) characterization and design for compatibility with board-level optical waveguide interconnection (2003)

Sea of leads (SoL) is a novel ultra-high-density compliant wafer-level packaging technology. The x-y-z compliant input/output (I/O) leads are batch fabricated by simply extending wafer-level batch fabrication of on-chip multilevel interconnect networks. Two-port microwave measurements reveal that the leads exhibit an insertion-loss of less than 0.4dB in the 0.1-45GHz frequency range. In addition, worst-case insertion-loss of signal propagation into and out of the package is 1.15dB at 45GHz. Because the compliant leads are short, their electrical parasitics are minimal. A mixed-signal system-on-a-chip (SoC) requires packages that are compatible with optical interconnect technology. Physical design rules describing SoL design compatibility with board-level optical signal distribution via waveguides are derived.
Modulation und dynamische Steuerung von auf intelligenten Dual-Active-Bridge-Umrichtern basierenden Umspannwerken für flexible Gleichstromnetze (2019)

This dissertation proposes improved modulation and dynamic control of high-power three-phase dual-active bridge (DAB3) dc-dc converters to enhance the operating performance and functionalities of intelligent dc substations in dc-grid applications. With the increasing integration of renewable energies, energy storage systems and the emerging fast charging stations for electric vehicles, dc distributions grids present numerous advantages e.g. higher efficiency, higher power capability and higher flexibility compared to existing ac grids. The key enabling component of flexible dc grids is the intelligent dc substation based on high-power dc-dc converters, which needs to achieve high efficiency over a wide voltage and power range, control the power flow and grid voltage dynamically, and ride through dc short-circuit faults. By employing the proposed asymmetrical duty cycle control method, the soft-switching range of the DAB3 converter is significantly extended over a wide voltage range especially in light-load conditions. Thereafter, the dissertation also introduces a novel method to control the transformer winding current and magnetizing flux of the DAB3 converter instantaneously and simultaneously under transient conditions. Thereby, the dc substation can control the power flow dynamically without causing transformer core saturation. Finally, a dc fault ride-through method for the DAB3 converter is proposed, which enables the breakerless protection of dc grids.
The 5-Alkoxymethyl-, 5-Alkylthiomethyl-, and 5-Dialkylaminomethylisoxazoles (1985)

3-)methylisoxazoles ( o b t a i n e d byt h e r e a c t i o n o f 1-rnethoxypentane-1,3-dione w i t h hydroxylamine),
Cavitation Plays a Vital Role in Stone Dusting During Short Pulse Holmium:YAG Laser Lithotripsy (2021)

<b><i>Objective:</i></b> To investigate the mechanism of stone dusting in Holmium (Ho): YAG laser lithotripsy (LL). <b><i>Materials and Methods:</i></b> Cylindrical BegoStone samples (6 × 6 mm, H × D) were treated in water using a clinical Ho:YAG laser lithotripter in dusting mode (0.2-0.4 J with 70-78 μs in pulse duration, 20 Hz) at various fiber tip to stone standoff distances (SD = 0, 0.5, and 1 mm). Stone damage craters were quantified by optical coherence tomography and bubble dynamics were captured by high-speed video imaging. To differentiate the contribution of cavitation <i>vs</i> thermal ablation to stone damage, three additional experiments were performed. First, presoaked wet stones were treated in air to assess stone damage without cavitation. Second, the laser fiber was advanced at various offset distances (OSD = 0.25, 1, 2, 3, and 10 mm) from the tip of a flexible ureteroscope to alter the dynamics of bubble collapse. Third, stones were treated with parallel fiber to minimize photothermal damage while isolating the contribution of cavitation to stone damage. <b><i>Results:</i></b> Treatment in water resulted in 2.5- to 90-fold increase in stone damage compared with those produced in air where thermal ablation dominates. With the fiber tip placed at OSD = 0.25 mm, the collapse of the bubble was distracted away from the stone surface by the ureteroscope tip, leading to significantly reduced stone damage compared with treatment without the scope or with scope at large OSD of 3-10 mm. The average crater volume produced by parallel fiber orientation at 0.2 J after 100 pulses, where cavitation is the dominant mechanism of stone damage, was comparable with those produced by using perpendicular fiber orientation within SD = 0.25-1 mm. <b><i>Conclusion:</i></b> Cavitation plays a dominant role over photothermal ablation in stone dusting during short pulse Ho:YAG LL when 10 or more pulses are delivered to the same location.
The MEK/ERK/miR-21 Signaling Is Critical in Osimertinib Resistance in EGFR-Mutant Non-Small Cell Lung Cancer Cells (2021)

Our results suggested that MEK/ERK/miR-21 signaling is critical in Osimertinib resistance and CAF transformation of NSCLC cells, and MEK inhibitor Trametinib significantly suppressed Osimertinib-resistant NSCLC tumor growth by abolishing both processes.
Enhancing effects of genes on IFN-α/5-FU treatment. (2015)

&lt;p&gt;(A–C).Viability of HepG2 cells infected with adenovirus-carrying protein kinase, adenosine monophosphate (AMP)-activated, gamma 2 non-catalytic subunit (&lt;i&gt;PRKAG2&lt;/i&gt;) (A), transforming growth factor-beta receptor II (&lt;i&gt;TGFBR2&lt;/i&gt;) (B), and exostosin 1 (&lt;i&gt;EXT1&lt;/i&gt;) (C) with or without 5-FU. Adenovirus-carrying LacZ served as a negative control. Cell viability was determined using the WST assay at 72 h. *&lt;i&gt;P&lt;/i&gt;&lt;0.05 and **&lt;i&gt;P&lt;/i&gt;&lt;0.01, between the two groups. (D) Viability of HepG2, HuH7, and HLF cells infected with adenovirus-carrying &lt;i&gt;TGFBR2&lt;/i&gt; and &lt;i&gt;EXT1&lt;/i&gt; with or without agents. Data are expressed as mean ± standard deviation (SD) (&lt;i&gt;n = &lt;/i&gt;3). Statistical significance was determined using Student’s &lt;i&gt;t&lt;/i&gt;-test. *&lt;i&gt;P&lt;/i&gt;&lt;0.05 between two groups. (E) In vivo studies using NOD/SCID mice subcutaneously transplanted with HepG2 cells. In adenoviruse-administered mice, tumor growth was assessed during IFN-α/5-FU treatment. Data are shown as means ± SD (&lt;i&gt;n = &lt;/i&gt;4–7).&lt;/p&gt;
ASSOCIATION OF INDUCED HEART RATE TURBULENCE WITH SEVERITY OF CORONARY ARTERY LESIONS IN CORONARY HEART DISEASE (2012)

Objectives Impaired heart rate turbulence (HRT) denotes abnormalities in cardiac autonomic function. We aimed to assess the correlation between coronary artery lesion and HRT induced by programmed electrical stimulation. Methods From January 2008 to January 2009, totally 113 patients (65 males and 48 females) who underwent coronary angiography were induced by programmed electrical stimulation and divided into four groups according to the number of coronary artery damage: normal control group (n=28), single vessel damage group (n=36), double vessels damage group (n=26) and many vessels damage group (n=23). The mean age of patients was (60.7±11.3) years (ranged from 45 to 74 years). After completion of coronary angiography, an extrastimulus was delivered from the right ventricular apex after 20 sinus beats with a V-S2 coupling interval decremented by 20 to 30 ms until refractoriness was reached. It was completed respectively for the measurement of heart rate, turbulence onset (TO), turbulence slope (TS) and Gemini's score of coronary stenosis. Results No serious complication were found during the programmed electrical stimulation, such as death and malignant ventricular arrhythmias. No significant differences were found in gender, age, blood pressure and heart rate. Compared with control group, TO was significantly higher but TS was significantly lower in coronary heart disease groups (p&lt;0.05 or p&lt;0.01). With the increasing severity of coronary heart disease, TO level was increased but TS level was decreased (p&lt;0.05 or p&lt;0.01). TS was negatively correlated with Gemini's score (r=−0.245, p=0.009) but TO was positively correlated with it (r=0.288, p=0.002). Balanced the influential factors such as age, gender, blood pressure and heart rate, TO and TS still had significantly correlated with Gemini's score (p&lt;0.01). Multiple regression analysis showed that Gemini's score was independent factor to influent TO and TS level. Conclusions Our data show that it is safe to measure induced HRT after coronary angiography in patients with coronary heart disease. The abnormal parameters of HRT have close relationship with the severity of coronary artery stenosis.
The role of nitric oxide in the large artery response to mental stress. (2007)

Arterial dysfunction is implicated in the development of LV dysfunction, and myocardial ischemia and infarction. Acute mental stress (AMS) increases aortic stiffness, pulse wave reflections and alters large artery endothelial function. We examined the role of nitric oxide (NO) in the large artery responses to AMS. Haemodynamic measurements were obtained using a bio-impedance monitor (TaskForce Monitor). Radial artery pressure waveforms were acquired using applanation tonometry and corresponding central waveforms were generated using pulse wave analysis (Sphygmocor). In control, AMS increased derived central systolic pressure (CSBP), heart rate corrected augmentation index (AI), and arterial load (EA), whilst decreasing total peripheral resistance (TPR). L-NMMA significantly increased CSBP, AI, EA and TPR at rest but had no influence on the magnitude of change in response to stress, indicating that NO has a significant basal role but little additional influence during AMS.
ReDCrypt (2018)

Artificial Intelligence (AI) is increasingly incorporated into the cloud business in order to improve the functionality (e.g., accuracy) of the service. The adoption of AI as a cloud service raises serious privacy concerns in applications where the risk of data leakage is not acceptable. Examples of such applications include scenarios where clients hold potentially sensitive private information such as medical records, financial data, and/or location. This article proposes ReDCrypt, the first reconfigurable hardware-accelerated framework that empowers privacy-preserving inference of deep learning models in cloud servers. ReDCrypt is well-suited for streaming (a.k.a., real-time AI) settings where clients need to dynamically analyze their data as it is collected over time without having to queue the samples to meet a certain batch size. Unlike prior work, ReDCrypt neither requires to change how AI models are trained nor relies on two non-colluding servers to perform. The privacy-preserving computation in ReDCrypt is executed using Yao’s Garbled Circuit (GC) protocol. We break down the deep learning inference task into two phases: (i) privacy-insensitive (local) computation, and (ii) privacy-sensitive (interactive) computation. We devise a high-throughput and power-efficient implementation of GC protocol on FPGA for the privacy-sensitive phase. ReDCrypt’s accompanying API provides support for seamless integration of ReDCrypt into any deep learning framework. Proof-of-concept evaluations for different DL applications demonstrate up to 57-fold higher throughput per core compared to the best prior solution with no drop in the accuracy.
Transcription of the Singing Melody in Polyphonic Music (MIREX 2006) (2006)

Weintroduce a method for the MIREX 2006 “Audio Melody Extraction” task in which the goal is to estimate fundamentalfrequency(F0) trajectory of the mainmelody within polyphonic music. The introduced method is based on multipleF0 estimation followed by acoustic and musicological modeling. The acoustic model consists of separate models for melody notes and for no-melody segments. The musicologicalmodeluseskeyestimationand notebigrams to determine the transition probabilities between notes. Viterbi decoding produces a sequence of notes and rests as a transcription of the melody. The method details are published in ISMIR 2006 proceedings. As an extension to this method, we use a simple F0 estimate selection to produce the required F0 trajectory for the task evaluation. Although the method was developed for the automatic transcription of singing melodies in polyphonic music, it is also applicable in general melody transcription tasks.
Lasers on Silicon (2011)

A number of important breakthroughs in the past decade have focused attention on Si as a photonic platform. We review here recent progress in this field, focusing on efforts to make lasers on or in silicon and on silicon photonic integrated circuits. The impact active silicon photonic integrated circuits could have on telecommunications and on silicon electronics is reviewed.
Bacterial virulence against an oceanic bloom-forming phytoplankter is mediated by algal DMSP (2018)

<i>Emiliania huxleyi</i> is a bloom-forming microalga that affects the global sulfur cycle by producing large amounts of dimethylsulfoniopropionate (DMSP) and its volatile metabolic product dimethyl sulfide. Top-down regulation of <i>E. huxleyi</i> blooms has been attributed to viruses and grazers; however, the possible involvement of algicidal bacteria in bloom demise has remained elusive. We demonstrate that a <i>Roseobacter</i> strain, <i>Sulfitobacter</i> D7, that we isolated from a North Atlantic <i>E. huxleyi</i> bloom, exhibited algicidal effects against <i>E. huxleyi</i> upon coculturing. Both the alga and the bacterium were found to co-occur during a natural <i>E. huxleyi</i> bloom, therefore establishing this host-pathogen system as an attractive, ecologically relevant model for studying algal-bacterial interactions in the oceans. During interaction, <i>Sulfitobacter</i> D7 consumed and metabolized algal DMSP to produce high amounts of methanethiol, an alternative product of DMSP catabolism. We revealed a unique strain-specific response, in which <i>E. huxleyi</i> strains that exuded higher amounts of DMSP were more susceptible to <i>Sulfitobacter</i> D7 infection. Intriguingly, exogenous application of DMSP enhanced bacterial virulence and induced susceptibility in an algal strain typically resistant to the bacterial pathogen. This enhanced virulence was highly specific to DMSP compared to addition of propionate and glycerol which had no effect on bacterial virulence. We propose a novel function for DMSP, in addition to its central role in mutualistic interactions among marine organisms, as a mediator of bacterial virulence that may regulate <i>E. huxleyi</i> blooms.
The TLR7/8/9 Antagonist IMO-8503 Inhibits Cancer-Induced Cachexia (2018)

: Muscle wasting is a feature of the cachexia syndrome, which contributes significantly to the mortality of patients with cancer. We have previously demonstrated that miR-21 is secreted through extracellular vesicles (EV) by lung and pancreatic cancer cells and promotes JNK-dependent cell death through its binding to the TLR7 receptor in murine myoblasts. Here, we evaluate the ability of IMO-8503, a TLR7, 8, and 9 antagonist, to inhibit cancer-induced cachexia. Using EVs isolated from lung and pancreatic cancer cells and from patient plasma samples, we demonstrate that IMO-8503 inhibits cell death induced by circulating miRNAs with no significant toxicity. Intraperitoneal administration of the antagonist in a murine model for Lewis lung carcinoma (LLC-induced cachexia) strongly impaired several cachexia-related features, such as the expression of Pax7 as well as caspase-3 and PARP cleavage in skeletal muscles, and significantly prevented the loss of lean mass in tumor-bearing mice. IMO-8503 also impaired circulating miRNA-induced cell death in human primary myoblasts. Taken together, our findings strongly indicate that IMO-8503 serves as a potential therapy for the treatment of cancer cachexia. SIGNIFICANCE: Cancer-associated cachexia is a significant problem for patients with cancer that remain poorly understood, understudied, and inadequately treated; these findings report a potential new therapeutic for the treatment of TLR7-mediated cancer cachexia.
Solid-phase synthesis of peptide amides on a polystyrene support using fluorenylmethoxycarbonyl protecting groups (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolid-phase synthesis of peptide amides on a polystyrene support using fluorenylmethoxycarbonyl protecting groupsBotond Penke and Jean RivierCite this: J. Org. Chem. 1987, 52, 7, 1197–1200Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://pubs.acs.org/doi/10.1021/jo00383a004https://doi.org/10.1021/jo00383a004research-articleACS PublicationsRequest reuse permissionsArticle Views518Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Recognition of influenza H3N2 variant virus by human neutralizing antibodies (2016)

Since 2011, over 300 human cases of infection, especially in exposed children, with the influenza A H3N2 variant (H3N2v) virus that circulates in swine in the US have been reported. The structural and genetic basis for the lack of protection against H3N2v induced by vaccines containing seasonal H3N2 antigens is poorly understood. We isolated 17 human monoclonal antibodies (mAbs) that neutralized H3N2v virus from subjects experimentally immunized with an H3N2v candidate vaccine. Six mAbs exhibited very potent neutralizing activity (IC<sub>50</sub> < 200 ng/ml) against the H3N2v virus but not against current human H3N2 circulating strains. Fine epitope mapping and structural characterization of antigen-antibody complexes revealed that H3N2v specificity was attributable to amino acid polymorphisms in the 150-loop and the 190-helix antigenic sites on the hemagglutinin protein. H3N2v-specific antibodies also neutralized human H3N2 influenza strains naturally circulating between 1995 and 2005. These results reveal a high level of antigenic relatedness between the swine H3N2v virus and previously circulating human strains, consistent with the fact that early human H3 seasonal strains entered the porcine population in the 1990s and reentered the human population, where they had not been circulating, as H3N2v about a decade later. The data also explain the increased susceptibility to H3N2v viruses in young children, who lack prior exposure to human seasonal strains from the 1990s.
Ecology of Danger‐dependent Cytokine‐boosted Spontaneous Abortion in the CBA × DBA/2 Mouse Model. I. Synergistic Effect of LPS and (TNF‐α + IFN‐γ) on Pregnancy Loss (2004)

High endogenous rates of abortion in the CBA x DBA/2 model may be explained by exposure to LPS at the time of mating. Increased rates of loss triggered by cytokines later in pregnancy may depend on increased absorption of LPS from intestinal flora.
(triple-helix DNA/biotinylated oligonucleotide/streptavidin/magnetic separation/dinucleotide repeat) (2016)

A DNA isolation procedure was developed by using triple-helix formation and magnetic separation. In this procedure, target DNA is captured by a biotinylated oligonu- cleotide via intermolecular triplex formation, bound to strepta- vidin-coated magnetic beads, and recovered in double- stranded form by elution with a mild alkaline buffer that destabilizes the triple helix. The effectiveness of the procedure was demonstrated by a model experiment with an artificially reconstructed library and, also, by the isolation of (dT- dC),(dG-dA), dinucleotide repeats from a human genomic library. This procedure provides a prototype for other triplex- mediated DNA isolation technologies.
Challenges in tin perovskite solar cells (2021)

Perovskite solar cells are the rising star of third-generation photovoltaic technology. With a power conversion efficiency of 25.5%, the record efficiency is close to the theoretical maximum efficiency of a single-junction solar cell. However, lead toxicity threatens commercialization efforts and market accessibility. In this context, Sn-based perovskites are a safe alternative. Nevertheless, the efficiency of Sn-based devices falls far behind the efficiency of Pb-based counterparts. This concise review sheds light on the challenges that the field faces toward making Sn-based perovskites the perovskite photovoltaic benchmark. We identified four key challenges: materials and solvents, film formation, Sn(II) oxidation, and energy band alignment. We illustrate every single challenge and highlight the most successful attempts to overcome them. Finally, we provide our opinion on the most promising trends of this field in the future.
ChemInform Abstract: Efficient Photoelectrochemical Solar Cells Equipped with an n‐Si Electrode Modified with Colloidal Platinum Particles. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.