gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Potential Antitumor Agents. Part 49. 5‐Substituted Derivatives of N‐(2‐ (Dimethylamino)ethyl)‐9‐aminoacridine‐4‐carboxamide with in vivo Solid‐ Tumor Activity. (1987)

Abstract Arylation of the anilines (I) with the iodoisophthalic acid (II) yields the diphenylamines (III) which undergo cyclization to give the acridones (IV).
Noninvasive predictors of perioperative atrial arrhythmias in patients with tetralogy of Fallot undergoing pulmonary valve replacement (2017)

In TOF patients undergoing pulmonary valve replacement, Pvm has significant value in predicting those with perioperative AFL/IART. These clinical features may help further evaluate TOF patients at risk for perioperative atrial arrhythmias. Prospective studies are warranted.
Stable Approximations of Unstable Models (2007)

This paper considers the following problem: starting from noisy data a model for the transfer function is estimated. For a finite number of data points, the model is not guaranteed to be stable, even when the true linear system is known to be stable. D'haene et al. [2006] describes an iterative procedure for calculating a stable approximation of an unstable model. This paper presents an improved algorithm resulting in significantly smaller approximation errors. In addition stable minimax solutions can also be generated.
Clinical imaging characteristics of the positron emission mammography PEM Flex Solo II (2008)

Positron emission mammography (PEM) uses two opposing gamma-ray imagers and limited-angle tomography techniques to image radiotracer distributions within the breast. Due to their smaller size and closer proximity to the source, dedicated PEM cameras can provide better spatial resolution and count sensitivity than whole-body positron emission tomographs. We performed several clinical imaging tests on a commercially available PEM camera, the PEM Flex Solo II. This system is comprised of two opposing 6 cm × 16.4 cm detectors that scan in unison to cover up to a 24 cm × 16.4 cm field of view (FOV). We measured spatial resolution, uniformity, recovery coefficients (RC), and quantification using the system clinical software. Image linearity and coefficient of variation (CV) at the edge of the FOV were also characterized. Anecdotal examples of clinical patient data are presented. Spatial resolution is 2.4 mm FWHM for image planes parallel to the detector faces; background variability is 6%; quantification and RC varied within the FOV; positioning linearity began at ~ 13 mm from the edge of the detector housing; CV increased rapidly at the edge of the FOV due to limited sampling in these image planes.
Sequential Stereoselective Catalysis: Two Single‐Flask Reactions of a Substrate in the Presence of a Bifunctional Chiral Ligand and Different Transition Metals (2003)

Abstract A new bifunctional ligand capable of promoting different stereoselective catalytic transformations in combination with different transition metals has been prepared by connecting with a spacer a bis(oxazoline) to dihydroquinidine; this ligand was employed in a one‐flask procedure in which methyl ( E )‐3‐(4‐vinylphenyl)propenoate underwent first cyclopropanation at the electron‐rich double bond and then dihydroxylation at the electron‐poor alkene to afford a product containing four stereocenters with complete regiocontrol and high stereoselectivity. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2003)
Adaptive Transmit-Receive Mode Selection for Multi-User Distributed Wireless Communication System (2007)

Distributed wireless communication system (DWCS) has been considered as a promising architecture for future wireless access networks. In this paper, we develop an adaptive transmit-receive mode selection scheme for a multi-user system with this architecture. In the proposed scheme, large-scale fading information between users and antennas is employed to decide the most appropriate mode from three available modes named independent processing mode, joint processing mode and time division mode. Selection criterion for a system with two single-antenna users and two distributed antennas is discussed in detail. Numerical results indicate that the proposed scheme achieves high capacity with relatively low complexity.
[Suppressor effect induced by sodium periodate on the antibody response of mouse splenic cells in vitro : inhibition of this effect by sodium borohydride]. (1979)

Theodore Roosevelt's secreatry encloses a letter from Mr. Cuthbert as representative of several letters sent to Roosevelt regarding delegates from Pennsylvania. Roosevelt finds the claims of these letters difficult to believe but wants it understood that since Senator Penrose "and the others" were defeated they should not be sent to Chicago.
Elucidating Aggregation Pathways in the Donor–Acceptor Type Molecules p-DTS(FBTTh2)2 and p-SIDT(FBTTh2)2 (2018)

We investigated the aggregation behavior of the donor-acceptor molecules p-DTS(FBTTh<sub>2</sub>)<sub>2</sub> (T1) and p-SIDT(FBTTh<sub>2</sub>)<sub>2</sub> (H1) in MTHF solutions. Using optical spectroscopy, we found that T1 forms aggregates in solution while H1 aggregates only when processed as a thin film, but not in solution. Free energy molecular dynamics (MD) simulations based on force fields derived from quantum-mechanical density functional theory fully reproduce this difference. Our simulations reveal that this difference is not due to the lengthy carbon side chains. Rather, the molecular symmetry of T1 allows for an aggregated state in which the central donor units are spatially well-separated while a similar configuration is sterically impossible for H1. As a consequence, any aggregation of H1 necessarily involves aggregation of the central donors which requires, as a first step, stripping the central donor of its protective MTHF solvation shell. This unfavorable process leads to a significant kinetic hindrance for aggregation and explains the strongly differing aggregation behavior of T1/H1 in MTHF despite their otherwise similar structures.
Infinite Nature: Perpetual View Generation of Natural Scenes from a Single Image (2021)

We introduce the problem of perpetual view generation— long-range generation of novel views corresponding to an arbitrarily long camera trajectory given a single image. This is a challenging problem that goes far beyond the capabilities of current view synthesis methods, which quickly degenerate when presented with large camera motions. Methods for video generation also have limited ability to produce long sequences and are often agnostic to scene geometry. We take a hybrid approach that integrates both geometry and image synthesis in an iterative ‘render, refine and repeat’ framework, allowing for long-range generation that cover large distances after hundreds of frames. Our approach can be trained from a set of monocular video sequences. We propose a dataset of aerial footage of coastal scenes, and compare our method with recent view synthesis and conditional video generation baselines, showing that it can generate plausible scenes for much longer time horizons over large camera trajectories compared to existing methods. Project page at https://infinite-nature.github.io.
Antitumor effects of B3-PE and B3-LysPE40 in a nude mouse model of human breast cancer and the evaluation of B3-PE toxicity in monkeys. (1992)

B3 is a tumor-reactive monoclonal antibody (mAb) that binds to a limited number of normal tissues. Immunotoxins made with B3 coupled to either Pseudomonas exotoxin (PE) or recombinant forms of PE with a deletion of the cell-binding domain (LysPE40) have been shown to cause complete tumor regression in nude mice bearing a rapidly growing A431 (L. H. Pai et al., Proc. Natl. Acad. Sci. USA, 88: 3358-3362, 1991) human epidermoid carcinoma. In this study we show that an immunotoxin composed of mAb B3 when chemically coupled to LysPE40 (B3-LysPE40) led to complete regression of a slowly growing breast cancer, MCF-7, in nude mice when given i.v. every other day for five doses. mAb B3 coupled to native PE also produced significant regression of the MCF-7 tumor. The reactivity of mAb B3 was evaluated using an immunohistochemical method on the two responsive tumors, MCF-7 and A431, and compared with a typical human colon carcinoma specimen that has B3 antigen on its surface. The results showed that both A431 and MCF-7 xenograft tumors have similar reactivity to B3 when compared with the human colon carcinoma specimen. To evaluate the toxicity of B3-PE in primates, Cynomolgus monkeys received escalating doses of B3-PE i.v. on Days 1, 3, and 5. Based on antibody localization studies using frozen sections of normal human and monkey tissue, gastric, trachea, and bladder mucosal injury could have occurred. However, no clinical signs of injury or histological damage to these organs were seen at the doses administered. Chemical hepatitis due to PE was transient and well tolerated at doses up to 50 micrograms/kg for three doses. The lethal dose was about 100 micrograms/kg, and the cause of death was liver necrosis, as shown by necropsy. We conclude that mAb B3, when coupled to PE40 or PE, can produce strong antitumor activity in vivo. The similar level of reactivity of the B3 antibody in our tumor models with a surgical specimen of a human colon carcinoma and the toxicity study in monkeys indicate that therapeutic doses of B3-PE and B3-LysPE40 can be delivered without causing toxicity to normal organs that express B3 antigen. Although both B3-PE and B3-LysPE40 have antitumor activity in nude mice bearing a human xenograft, B3-LysPE40 is better tolerated and should be further evaluated as a therapeutic agent for cancer patients.
Aqueous catalyst systems for the water-gas shift reaction. 3. Continuous gas processing results (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAqueous catalyst systems for the water-gas shift reaction. 3. Continuous gas processing resultsDouglas C. Elliott, L. John Sealock Jr., and R. Scott ButnerCite this: Ind. Eng. Chem. Prod. Res. Dev. 1986, 25, 4, 541–549Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/i300024a007https://doi.org/10.1021/i300024a007research-articleACS PublicationsRequest reuse permissionsArticle Views214Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Integrin α IIb β 3 and Its Antagonism (2003)

AlphaIIbbeta3, the major membrane protein on the surface of platelets, is a member of the integrin family of heterodimeric adhesion receptors. The alphaIIb and beta3 subunits are each composed of a short cytoplasmic tail, a single transmembrane domain, and a large, extracellular region that consists of a series of linked domains. Recent structural analyses have provided insights into the organization of this and other integrins and how a signal is initiated at its cytoplasmic tail to transform the extracellular domain of alphaIIbbeta3 into a functional receptor for fibrinogen or von Willebrand factor to support platelet aggregation and thrombus formation. These functions of alphaIIbbeta3 have been targeted for antithrombotic therapy, and intravenous alphaIIbbeta3 antagonists have been remarkably effective in the setting of percutaneous coronary interventions, showing both short-term and long-term mortality benefits. However, the development of oral antagonists has been abandoned on the basis of excess of mortality in clinical trials, and the extension of therapy with existing alphaIIbbeta3 antagonists to broadly treat acute coronary syndromes has not fully met expectations. An in-depth understanding of how antagonists engage and influence the function of alphaIIbbeta3 and platelets in the context of the new structural insights may explain its salutary and potential deleterious effects.
Design, Synthesis, and Biological Evaluation of Allosteric Effectors That Enhance CO Release from Carboxyhemoglobin (2018)

Carbon monoxide (CO) poisoning causes between 5,000-6,000 deaths per year in the US alone. The development of small molecule allosteric effectors of CO binding to hemoglobin (Hb) represents an important step toward making effective therapies for CO poisoning. To that end, we have found that the synthetic peptide IRL 2500 enhances CO release from COHb in air, but with concomitant hemolytic activity. We describe herein the design, synthesis, and biological evaluation of analogs of IRL 2500 that enhance the release of CO from COHb without hemolysis. These novel structures show improved aqueous solubility and reduced hemolytic activity and could lead the way to the development of small molecule therapeutics for the treatment of CO poisoning.
Si-Ge-Sn alloys with 1.0 eV gap for CPV multijunction solar cells (2015)

Si-Ge-Sn ternary group IV alloys offer an alternative to currently used 1.0 eV gap materials utilized in multijunction solar cells. The advantage of Si-Ge-Sn is the ability to vary both the bandgap and lattice parameter independently. We present current development in fabrication of Si-Ge-Sn alloys with gaps in the 1.0 eV range. Produced material exhibits excellent structural properties, which allow for integration with existing III-V photovoltaic cell concepts. Time dependent room temperature photoluminescence data demonstrate that these materials have long carrier lifetimes. Absorption tunable by compositional changes is observed. As a prototype device set utilizing the 1 eV Si-Ge-Sn junction, single junction Si-Ge-Sn device and triple junction device with Si-Ge-Sn subcell have been fabricated. The resulting I-V and external quantum efficiency data show that the Si-Ge-Sn junction is fully functional and the performance is comparable to other 1.0 eV gap materials currently used.
A Single Dose of the DENV-1 Candidate Vaccine rDEN1Δ30 Is Strongly Immunogenic and Induces Resistance to a Second Dose in a Randomized Trial (2011)

Dengue is an emerging infectious disease that has become the most important arboviral infection worldwide. There are four serotypes of dengue virus, DENV-1, DENV-2, DENV-3, and DENV-4, each capable of causing the full spectrum of disease. rDEN1Δ30 is a live attenuated investigational vaccine for the prevention of DENV-1 illness and is also a component of an investigational tetravalent DENV vaccine currently in Phase I evaluation. A single subcutaneous dose of rDEN1Δ30 was previously shown to be safe and immunogenic in healthy adults. In the current randomized placebo-controlled trial, 60 healthy flavivirus-naive adults were randomized to receive 2 doses of rDEN1Δ30 (N = 50) or placebo (N = 10), either on study days 0 and 120 (cohort 1) or 0 and 180 (cohort 2). We sought to evaluate the safety and immunogenicity of this candidate vaccine in 50 additional vaccinees and to test whether the humoral immune response could be boosted by a second dose administered 4 or 6 months after the first dose. The first dose of vaccine was well tolerated, infected 47/50 vaccinees and induced seroconversion in 46/50 vaccinees. Irrespective of dosing interval, the second dose of vaccine was also well tolerated but did not induce any detectable viremia or ≥4-fold rise in serum neutralizing antibody titer.Only five subjects had an anamnestic antibody response detectable by ELISA following a second dose of vaccine, demonstrating that the vaccine induced sterilizing humoral immunity in most vaccinees for at least six months following primary vaccination.The promising safety and immunogenicity profile of this vaccine confirms its suitability for inclusion in a tetravalent dengue vaccine.
Effective transfection of a cis element “decoy” of the nuclear factor-?B binding site into the experimental choroidal neovascularization (2002)

A decoy can be transfected into retinal cells and cells within a choroidal neovascularization by the HVJ-liposome method. The transferred NF-kappaB decoy reduced the degree of choroidal neovascularization. Decoy targeted against NF-kappaB may be considered as a potential therapy for neovascularization.
Control of stress and plasma-induced heating during dc magnetron sputtering of permalloy films for microelectromechanical systems (2002)

Low stress (&amp;lt;25 MPa), magnetically soft films of permalloy (Ni80Fe20) were deposited for microelectromechanical system based data storage application without significant plasma-induced substrate heating. Optimization of film properties was performed using a designed experiment, response surface methodology. In this study, the formation of an undesirable magnetic stripe domain structure formation degraded the magnetic properties of permalloy film. The relationship between the results of the factorial experiment are explained based on Murayama’s stripe domain theory.
ChemInform Abstract: An anti CuO2‐Type Metal Hydride Square Net Structure in Ln2M2As2Hx (Ln: La or Sm, M: Ti, V, Cr, or Mn). (2015)

Abstract The new title hydrides (x ≈ 3) are synthesized by high temperature/high‐pressure reactions of M (M: Ti, V, Cr, Mn), LnAs (Ln: La, Sm), and LaF 3 , using mixtures of Ca(OH) 2 and NaBH 4 as the hydrogen source (1473—1573 K, 2.5—5.0 GPa, 0.5—1.0 h).
Efficient Strand Transfer by the RadA Recombinase from the Hyperthermophilic Archaeon Desulfurococcus amylolyticus (2000)

The radA gene predicted to be responsible for homologous recombination in a hyperthermophilic archaeon, Desulfurococcus amylolyticus, was cloned, sequenced, and overexpressed in Escherichia coli cells. The deduced amino acid sequence of the gene product, RadA, was more similar to the human Rad51 protein (65% homology) than to the E. coli RecA protein (35%). A highly purified RadA protein was shown to exclusively catalyze single-stranded DNA-dependent ATP hydrolysis, which monitored presynaptic recombinational complex formation, at temperatures above 65 degrees C (catalytic rate constant of 1.2 to 2.5 min(-1) at 80 to 95 degrees C). The RadA protein alone efficiently promoted the strand exchange reaction at the range of temperatures from 80 to 90 degrees C, i.e., at temperatures approaching the melting point of DNA. It is noteworthy that both ATP hydrolysis and strand exchange are very efficient at temperatures optimal for host cell growth (90 to 92 degrees C).
Reliability of dielectric barriers in copper damascene applications (2003)

The film properties of two PECVD deposited dielectric copper barrier films have been optimized to improve BEOL device reliability in terms of electromigration. Two critical aspects that affect electromigration are the dielectric barrier film hermeticity and adhesion to copper. We use a method to quantify the barrier film hermeticity of the BLO/spl kappa/ I low-/spl kappa/ dielectric film to be similar to that of silicon nitride. In addition, the interfaces between damascene nitride with copper, as well as BLO/spl kappa/ I with copper have been engineered to improve the interfacial adhesion energy to >10 J/m/sup 2/ for both damascene nitride and BLO/spl kappa/ I.
Multilevel Programmable Oxide Diode for Cross-Point Memory by Electrical-Pulse-Induced Resistance Change (2009)

A multilevel one-time programmable (OTP) oxide diode for cross-point memory is introduced. The oxide diode is composed of a thin-film p-CuO/n-InZnO <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</i> (IZO). By applying negative electrical pulses, the p-CuO/n-IZO diode exhibited multilevel resistance states, and such characteristics of the p-CuO/n-IZO diode could be utilized as the cell of OTP cross-point memory. The resistance-change properties of the p-CuO/n-IZO diode originated possibly from a back-to-back diode phenomenon by oxygen ion migration in the IZO thin film.
<title>Diode-pumped-cw and quasi-cw Nd:GGG(Ca,Mg,Zr) laser</title> (1994)

A Nd:GGG(Ca,Mg,Zr) and a Nd:YAG laser were compared when end-pumped by a continuous-wave laser diode. With a 30-mW single-stripe laser diode, 2.4 mW and 4.6 mW of output power were obtained for the Nd:GGG(Ca,Mg,Zr) and the Nd:YAG laser, respectively. With a 1-watt laser-diode array, the output power increased to 223 mW for the Nd:GGG(Ca,Mg,Zr) and 297 mW for the Nd:YAG laser. The Nd:GGG(Ca,Mg,Zr) was also pumped by a 19-watt quasi-continuous-wave laser-diode bar. Side and end pumping were compared. With the appropriate optics the end-pumped geometry was more efficient and gave more power, 47% slope efficiency with 4.3 watts of output power, compared to side-pumped geometry, 16% slope efficiency with 2.6 watts.
Model predictive control of interleaved dc-dc stage for photovoltaic microconverters (2015)

The development of different configurations and topologies implemented in photovoltaic (PV) plants have made possible the increase of efficiency of the system. The traditional configurations of grid-connected PV systems, centralized, string, multi-string and ac-module, have been analyzed and actually most of them are controlled using classic PI control. Furthermore, each of them has different efficiency values due to the inherent associated problems. The large-scale PV plants do not work properly when the modules do not work at the same conditions, for example when some atmospheric and environmental problems are involved, it reduces the reliability of the system. The traditional small-scale PV configurations have a low efficiency due to the dc-boosting stage in order to reach the grid levels. This work presents a grid-connected PV configuration, focused in the improve of the efficiency of the traditional ac-module configuration, a flyback topology for the dc-side and a H-bridge topology for the grid connection will be implemented. Moreover, the proposed control scheme is based on FCS-MPC algorithm.
Short Period Demultiple Using Iterative Second Order Multi-dimensional Predictive Deconvolution (2017)

Summary 2D deconvolution is an attractive approach for short period multiple prediction as it does not require direct recording of the multiple generator and can model multiples relating to more than one multiple generator at a time. One drawback, however, relates to an inherent over-prediction of mixed side multiples as well as some shallow multiples, leading to an inconsistency in the amplitude of multiple predictions from one multiple order to the next. We present a modified form of predictive deconvolution that corrects for these errors by iteratively refining the data used for the gapped deconvolution solver. The resulting multiple prediction is consistent with the amplitude of multiples in the recorded data, reducing the necessity for adaptive subtraction. The algorithm may be applied in 2D or 3D, or alternatively with a receiver only side 3D implementation suited to towed streamer geometries. The effectiveness of the algorithm is demonstrated on synthetic data as well as on two towed streamer 3D seismic data examples acquired in the North Sea.