gebhart/patrepeval huggingface dataset:
Characterization of PXK as a Protein Involved in Epidermal Growth Factor Receptor Trafficking (2010)

The phox homology (PX) domain is a phosphoinositide-binding module that typically binds phosphatidylinositol 3-phosphate. Out of 47 mammalian proteins containing PX domains, more than 30 are denoted sorting nexins and several of these have been implicated in internalization of cell surface proteins to the endosome, where phosphatidylinositol-3-phosphate is concentrated. Here we investigated a multimodular protein termed PXK, composed of a PX domain, a protein kinase-like domain, and a WASP homology 2 domain. We show that the PX domain of PXK localizes this protein to the endosomal membrane via binding to phosphatidylinositol 3-phosphate. PXK expression in COS7 cells accelerated the ligand-induced internalization and degradation of epidermal growth factor receptors by a mechanism requiring phosphatidylinositol 3-phosphate binding but not involving the WASP homology 2 domain. Conversely, depletion of PXK using RNA interference decreased the rate of epidermal growth factor receptor internalization and degradation. Ubiquitination of epidermal growth factor receptor by the ligand stimulation was enhanced in PXK-expressing cells. These results indicate that PXK plays a critical role in epidermal growth factor receptor trafficking through modulating ligand-induced ubiquitination of the receptor.
A novel continuous noninvasive estimation of systolic blood pressure (2015)

Continuous non-invasive blood pressure (BP) monitoring has been under intensive investigation by the clinical and technical community. The photoplethysmography (PPG) signal, measured unobtrusively at distal sites, serves as a popular surrogate. This is due to the fact that it indicates pulsatile blood volume changes and is morphologically similar to the continuous BP signal. From PPG and ECG, pulse arrival time (PAT) based methods are widely studied. However, PAT is determined not only by BP but also vasoregulation and vascular properties, making it an unstable estimator per se. Multiple features derived from a PPG signal have been used to estimate BP, but they either require calibration, fail to validate its ability to track BP, or ignore the abundant information contained within the PPG waveform [1,2]. In this study, we introduce BP changes in 18 healthy subjects, explore a number of features from various perspectives, and determine the performance of tracking Systolic Blood Pressure (SBP) in the absence of calibration. Besides PAT, we include timing features (time from systolic slope to dicrotic notch), and amplitude features (normalized systolic slope mean, variance and diastolic slope mean,
Colorless Polyimide Containing Phenoxy-Linked Diamines (1986)

Tough, optically transparent films produced. Polyimides having this molecular structure form tough, transparent films. Films made transparent by careful control of manufacturing conditions, including use of highly purified monomers. Need for high-temperature, flexible polymeric films and coating materials that have high optical transparency in 300- to 600nm range of electro-magnetic spectrum for use on antennas, solar cells, and thermalcontrol coatings.
A Conceptual Framework for the Development of a Course in Nano/Micro-Scale Systems Engineering (2013)

A Conceptual Framework for the Development of a Course in Nano/Micro-Scale Systems Engineering Cetin Cetinkaya1 ∗, Ian I. Suni2, Silvana Andreescu3, Mandy B. Esch4, Weili Cui5, David J. Jones6, Stephen Jones5, Gregory S. Chojecki7, James D. Stephens1, and Armin S. Vahdat1 1Department of Mechanical and Aeronautical Engineering, 2Materials Technology Center, Southern Illinois University, Carbondale, IL 62901, USA 3Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA 4Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA 5Department of Mechanical Engineering, State University of New York at Binghamton, Binghamton, NY 13902, USA 6Global Foundries, Malta, NY 12020, USA 7Department of Chemical and Biomolecular Engineering, Clarkson University, Potsdam, NY 13699, USA
End-to-end voice over IP quality of service estimation through router queuing delay monitoring (2003)

Service variability in IP networks creates the need for QoS (quality of service) assessment tools. These tools must provide estimations of the quality of service through different paths in the network. Some existing schemes require a large number of probe packets to be sent to achieve accurate estimates. Others use traffic monitoring with administrative control, the most adopted of which being SNMP (simple network management protocol) and RMON (remote monitoring). We propose a quality of service estimation mechanism for voice over IP (VoIP) that necessitates a small number of probe packets while adding simple queuing delay estimation functionality in core routers. The underlying concept is that variation in delay, jitter and available bandwidth, as seen by a voice application, is due to queuing variations at intermediate hops. Collecting and combining queuing delay estimates from core routers can therefore be used to obtain accurate QoS estimates. Our results indicate better performance than existing QoS estimation tools under similar conditions.
3‐D AVO migration/inversion of field data (1997)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 19973‐D AVO migration/inversion of field dataAuthors: Ali TuraChristian HanitxschHenri CalandraAli TuraElf GRC, London, U.K., Christian HanitxschElf CSTJF, Pau, France, and Henri CalandraElf CSTJF, Pau, Francehttps://doi.org/10.1190/1.1885866 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1885866FiguresReferencesRelatedDetailsCited byReferences21 March 2012Can we quantitatively image complex structures with rays?M. Stéphane Operto, Sheng Xu, and Gilles Lambaré7 February 2012 | GEOPHYSICS, Vol. 65, No. 4Fast 2-D ray+Born migration/inversion in complex mediaPhilippe Thierry, Stéphane Operto, and Gilles Lambaré8 October 1998 | GEOPHYSICS, Vol. 64, No. 13-D preserved amplitude prestack depth migration on a workstationPhilippe Thierry, Gilles Lambaré, Pascal Podvin, and Mark S. Noble8 October 1998 | GEOPHYSICS, Vol. 64, No. 1 SEG Technical Program Expanded Abstracts 1997ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1997 Pages: 2067 publication data© 1997 Copyright © 1997 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Ali Tura, Christian Hanitxsch, and Henri Calandra, (1997), "3‐D AVO migration/inversion of field data," SEG Technical Program Expanded Abstracts : 214-217. https://doi.org/10.1190/1.1885866 Plain-Language Summary PDF DownloadLoading ...
A Ka-band Switched-Capacitor RFDAC Using Edge-Combining in 22nm FD-SOI (2021)

The paper proposes an RFDAC based on an edge-combining (EC) switched-capacitor power amplifier (SCPA) that triples its clock frequency directly in the output stage to enable a near-mm-wave operation. Another edge-combining based frequency-tripling DLL network increases the system efficiency while a new layout structure accounts for the distributed effects of combining transmission lines. Implemented in 22nm FD-SOI, the prototype achieves P <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</inf> >21 dBm, DE>36%, SE>22% while operating in the Ka-band at 27.9GHz. Modulation at 2.4Gb/s results in 3.3% EVM and 30.8dBc ACLR.
Marginal Space Deep Learning: Efficient Architecture for Volumetric Image Parsing (2016)

Robust and fast solutions for anatomical object detection and segmentation support the entire clinical workflow from diagnosis, patient stratification, therapy planning, intervention and follow-up. Current state-of-the-art techniques for parsing volumetric medical image data are typically based on machine learning methods that exploit large annotated image databases. Two main challenges need to be addressed, these are the efficiency in scanning high-dimensional parametric spaces and the need for representative image features which require significant efforts of manual engineering. We propose a pipeline for object detection and segmentation in the context of volumetric image parsing, solving a two-step learning problem: anatomical pose estimation and boundary delineation. For this task we introduce Marginal Space Deep Learning (MSDL), a novel framework exploiting both the strengths of efficient object parametrization in hierarchical marginal spaces and the automated feature design of Deep Learning (DL) network architectures. In the 3D context, the application of deep learning systems is limited by the very high complexity of the parametrization. More specifically 9 parameters are necessary to describe a restricted affine transformation in 3D, resulting in a prohibitive amount of billions of scanning hypotheses. The mechanism of marginal space learning provides excellent run-time performance by learning classifiers in clustered, high-probability regions in spaces of gradually increasing dimensionality. To further increase computational efficiency and robustness, in our system we learn sparse adaptive data sampling patterns that automatically capture the structure of the input. Given the object localization, we propose a DL-based active shape model to estimate the non-rigid object boundary. Experimental results are presented on the aortic valve in ultrasound using an extensive dataset of 2891 volumes from 869 patients, showing significant improvements of up to 45.2% over the state-of-the-art. To our knowledge, this is the first successful demonstration of the DL potential to detection and segmentation in full 3D data with parametrized representations.
A multimode, switching-surface controlled dc-dc converter with improved light-load efficiency (2012)

This paper describes a switching-surface (SS) controlled dc-dc converter that operates in PFM (pulse-frequency modulation) mode. SS control in continuous-current mode (CCM) has, as an essential property, fast response to load transient. To realize the SS control, a simple circuit that generates a switching function by using only one operational amplifier is proposed. In addition to the CCM operation, PFM mode operation is implemented to enhance efficiency at light load. The proposed converter seamlessly switches between CCM and PFM modes depending on load current. Experimental results for a 1 A, 5 to 1.2 V buck converter are shown. The response to a load transient is nearly optimal, limited by only the power-stage components. By using the proposed PFM mode, efficiency is improved by 30% at an output of 10 mA.
An aperture-coupled patch antenna in RFIC package for 60 GHz applications (2012)

This paper presents an aperture-coupled patch antenna integrated in the RFIC package environment for 60 GHz applications. The package is based on multilayer organic technology, so it can be fabricated by PCB manufacturers. The antenna has at least 6 dBi gain at the 60 GHz band.
Unsaturated fatty acids and a prenylated tryptophan derivative from a rare actinomycete of the genus Couchioplanes (2021)

A genome mining survey combined with metabolome analysis of publicly available strains identified <i>Couchioplanes</i> sp. RD010705, a strain belonging to an underexplored genus of rare actinomycetes, as a producer of new metabolites. HPLC-DAD-guided fractionation of its fermentation extracts resulted in the isolation of five new methyl-branched unsaturated fatty acids, (2<i>E</i>,4<i>E</i>)-2,4-dimethyl-2,4-octadienoic acid (<b>1</b>), (2<i>E</i>,4<i>E</i>)-2,4,7-trimethyl-2,4-octadienoic acid (<b>2</b>), (<i>R</i>)-(-)-phialomustin B (<b>3</b>), (2<i>E</i>,4<i>E</i>)-7-hydroxy-2,4-dimethyl-2,4-octadienoic acid (<b>4</b>), (2<i>E</i>,4<i>E</i>)-7-hydroxy-2,4,7-trimethyl-2,4-octadienoic acid (<b>5</b>), and one prenylated tryptophan derivative, 6-(3,3-dimethylallyl)-<i>N</i>-acetyl-ʟ-tryptophan (<b>6</b>). The enantiomer ratio of <b>4</b> was determined to be approximately <i>S</i>/<i>R</i> = 56:44 by a recursive application of Trost's chiral anisotropy analysis and chiral HPLC analysis of its methyl ester. Compounds <b>1</b>-<b>5</b> were weakly inhibitory against <i>Kocuria rhizophila</i> at MIC 100 μg/mL and none were cytotoxic against P388 at the same concentration.
Identification of 4-(4-Aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as Selective Inhibitors of Protein Kinase B through Fragment Elaboration (2008)

Fragment-based screening identified 7-azaindole as a protein kinase B inhibitor scaffold. Fragment elaboration using iterative crystallography of inhibitor-PKA-PKB chimera complexes efficiently guided improvements in the potency and selectivity of the compounds, resulting in the identification of nanomolar 6-(piperidin-1-yl)purine, 4-(piperidin-1-yl)-7-azaindole, and 4-(piperidin-1-yl)pyrrolo[2,3- d]pyrimidine inhibitors of PKBbeta with antiproliferative activity and showing pathway inhibition in cells. A divergence in the binding mode was seen between 4-aminomethylpiperidine and 4-aminopiperidine containing molecules. Selectivity for PKB vs PKA was observed with 4-aminopiperidine derivatives, and the most PKB-selective inhibitor (30-fold) showed significantly different bound conformations between PKA and PKA-PKB chimera.
Low Polarization Microscope Objectives (2010)

Microscope objectives used for biaxial ellipsometry require small levels of polarization aberrations. The approach outlined in this paper allows the design and fabrication of microscope objectives with twelve times less diattenuation than commercially available objectives.
Industrial Cyber–Physical Systems [Scanning the Issue] (2016)

The articles in this special issue present the latest developments and achievements in industrial cyber-physical systems (ICPSs). The papers in this issue cover key areas on architecture, design,enabling technologies, and applications of ICPSs. Additionally, they present emerging trends and visions of ICPSs for future investigations.
<title>Systematic bias in OCR experiments</title> (1995)

In this paper, we examine the effects of systematic differences (bias) and sample size (variance) on computed OCR accuracy. We present results from large-scale experiments simulating several groups of researchers attempting to perform the same test, but using slightly different equipment and procedures. We first demonstrate that seemingly minor systematic differences between experiments can result in significant biases in the computed OCR accuracy. Then we show that while a relatively small number of pages is sufficient to obtain a precise estimate of accuracy in the case of `clean' input, real-world degradation can greatly increase the required sample size.
The Influence of Solid-State Morphology on the Dart Impact Strength of Linear Low-Density Polyethylene Blown Films (2005)

In this study, we report on the influence of lamellar morphology and orientation on the dart impact strength of linear low-density polyethylene (LLDPE) blown films. Evidence confirming the importance of lamellar anisotropy on the impact strength performance of such films is presented. Specifically, lower degree of lamellar orientation (more random orientation) is shown to favor higher impact strengths. We also note that the films stretch considerably during the measurement of dart impact strength with the initial morphology influencing the stretching process.
Evaluation of Known Oncoantibodies, HER2, p53, and Cyclin B1, in Prediagnostic Breast Cancer Sera (2012)

Serum autoantibodies, directed against oncogenic proteins, have been frequently detected in the sera of patients with breast cancer. It is unknown whether serum antibodies that are identified in patients with established disease could also be detected in patients with newly diagnosed disease or even predate the diagnosis of breast cancer. Using sera collected at the time of treatment, at the time of diagnosis, or before the time of diagnosis, the current study aimed to address the temporal relationship between breast cancer development and serum antibody response. Starting from serum antibodies to eight known breast cancer antigens, we first identified four serum antibodies, HER2/neu, p53, carcinoembryonic antigen (CEA), and cyclin B1, which are significantly increased in the sera collected from patients with breast cancer at the time of treatment. These antibodies were also elevated in breast cancer sera collected at the time of diagnosis. Finally, comparison of antibody responses in prediagnostic samples from women before the development of breast cancer and in controls showed that antibodies to the HER2/neu and p53 can be detected in sera that were collected on average more than 150 days before a breast cancer diagnosis. These results showed that serum autoantibodies commonly reported in sera from patients with established disease can also be detected in prediagnostic sera and may be useful for the early detection of breast cancer.
The Search Minerals Direct Extraction Process for Rare Earth Element Recovery (2016)

The Search Minerals Foxtrot project in Labrador is a surface deposit enriched in the highly sought after heavy rare earth elements. Early metallurgical work investigated beneficiation of the rare earth content of the Foxtrot resource using flotation, gravity separation and magnetic separation. The concentrate was then processed by acid baking and water leaching to produce a REE leachate for purification and recovery. The Search Minerals Direct Extraction Process was developed through bypassing the beneficiation process and directly acid treating a coarse crushed ore material prior to water leaching. The result is a simple, low risk technical process for direct recovery. Concurrently, the treatment of the water leach solution was modified to produce a high grade (98.9% total rare earth oxide) product for refining.
Comparing mortality of colorectal cancer and gastrointestinal bleeding among patients with long-term use of low dose aspirin: A population-based study of 689,209 patients. (2017)

527 Background: Aspirin, commonly used for prevention of cardiovascular and cerebrovascular diseases, is well-known to protect against colorectal cancer (CRC) development but increase risk of gastrointestinal bleeding (GIB). Few large-scale studies have compared the benefit and risk of long-term aspirin usage. This cohort study aims to evaluate the use of low-dose aspirin to prevent CRC and the risk of GIB associated with the aspirin use. Methods: A population-based clinical dataset was used to compare incidence and mortality of CRC and GIB patients receiving low-dose aspirin with sex-and-age matched controls (in 1:2 ratio). Patients with aspirin≤6 months were excluded. Clinical data of 206,243 aspirin users (mean dose 80 mg/day, mean duration 7.7 years) and 482,966 non-users were included. All patients must have at least 10-year follow up on clinical outcome. Results: Among aspirin users 5,776 (2.80%) were diagnosed with CRC; 2,097 (1.02%) died of the malignancy. 16,483 (3.41%) non-users were diagnosed with CRC; 7,963 (1.65%) died of CRC. Using the cox-proportional hazard regression, aspirin usage showed a modest but significant reduction in CRC mortality (HR = 0.65; 95% CI = 0.62 to 0.69). On the other hand, 11,187 (5.42%) aspirin users developed GIB, and 841 (0.41%) died. 15,186 (3.14%) non-users developed GIB, and 1,682 patients (0.35%) died. Aspirin users showed modest but significant increased risk of GIB-related mortality (HR = 1.24; 95% CI = 1.14 to 1.35). Conclusions: The long-term use of low dose aspirin shows preventive effect on CRC, but also increases the associated GIB risk. Considerations of prophylactic use of aspirin should balance the benefit and the risk of this treatment to the target population. [Table: see text]
Translational Diffusion in Polydisperse Polymer Samples Studied by Dynamic Imaging of Diffusion ESR (1996)

A new methodology utilizing the DID-ESR (dynamic imaging of diffusion by ESR) technique has been developed for its application to polydisperse polymer samples. Due to polydispersity the spin-labeled polymer molecules have a wide range of molecular weight, and this is also true for the matrix polymer molecules. This generally leads to a wide distribution in diffusion coefficients of the spin-labeled molecules. The work presented here includes a theoretical derivation of the new DID-ESR method in the presence of polydispersity, plus its first application for measuring translational diffusion coefficients of liquid crystalline (LC) polymer melts. This includes a detailed analysis of the reliability of the method, the proper interpretation of average diffusion coefficients, and how the molecular weight dependence of the diffusion coefficient may be obtained from even a single experiment on a sample with wide polydispersity. The results obtained by this method are compared with those from the FRES (forward recoil spectroscopy) technique on the same model system, but for higher molecular weight, and account is taken of the differences in the two methods. Future experiments to further study LC polymer diffusion mechanisms are proposed.
Doping and damage dose dependence of implant induced transient enhanced diffusion below the amorphization threshold (1994)

Special test structures were used to isolate the dependence of transient enhanced diffusion on damage dose and on doping concentration. The structures consisted of 200 nm boron-doped layers with an undoped silicon capping layer 300 nm thick. The boron concentrations varied from 5×1016 to 5×1018/cm3. Damage was introduced by 75 keV, Si implants with doses ranging from 1×1012 to 5×1013/cm2. Annealing at 750 °C for 120 min produced a large enhancement in the boron diffusivity. The enhancement increased with increasing Si dose, but in a sublinear manner. The enhancement decreased with increasing boron doping concentration, even for doping concentrations below the intrinsic electron concentration. A phenomenological defect-doping reaction model is described which predicts both of these essential features of damage enhanced diffusion. We conclude that it will be necessary to treat the full coupling between defects and dopant atoms in order to model damage enhanced diffusion effects.
TLS Dynamics in a Superconducting Qubit Due to Background Ionizing Radiation (2022)

Superconducting qubit lifetimes must be both long and stable to provide an adequate foundation for quantum computing. This stability is imperiled by two-level systems (TLSs), currently a dominant loss mechanism, which exhibit slow spectral dynamics that destabilize qubit lifetimes on hour timescales. Stability is also threatened at millisecond timescales, where ionizing radiation has recently been found to cause bursts of correlated multi-qubit decays, complicating quantum error correction. Here we study both ionizing radiation and TLS dynamics on a 27-qubit processor, repurposing the standard transmon qubits as sensors of both radiation impacts and TLS dynamics. Unlike prior literature, we observe resilience of the qubit lifetimes to the transient quasiparticles generated by the impact of radiation. However, we also observe a new interaction between these two processes, "TLS scrambling," in which a radiation impact causes multiple TLSs to jump in frequency, which we suggest is due to the same charge rearrangement sensed by qubits near a radiation impact. As TLS scrambling brings TLSs out of or in to resonance with the qubit, the lifetime of the qubit increases or decreases. Our findings thus identify radiation as a new contribution to fluctuations in qubit lifetimes, with implications for efforts to characterize and improve device stability