gebhart/patrepeval huggingface dataset:
Image structural analysis in the tasks of automatic navigation of unmanned vehicles and inspection of Earth surface (2013)

The automatic analysis of images of terrain is urgent for several decades. On the one hand, such analysis is a base of automatic navigation of unmanned vehicles. On the other hand, the amount of information transferred to the Earth by modern video-sensors increases, thus a preliminary classification of such data by onboard computer becomes urgent. We developed an object-independent approach to structural analysis of images. While creating the methods of image structural description, we did our best to abstract away from the partial peculiarities of scenes. Only the most general limitations were taken into account, that were derived from the laws of organization of observable environment and from the properties of image formation systems. The practical application of this theoretic approach enables reliable matching the aerospace photographs acquired from differing aspect angles, in different day-time and seasons by sensors of differing types. The aerospace photographs can be matched even with the geographic maps. The developed approach enabled solving the tasks of automatic navigation of unmanned vehicles. The signs of changes and catastrophes can be detected by means of matching and comparison of aerospace photographs acquired at different time. We present the theoretical proofs of chosen strategy of structural description and matching of images. Several examples of matching of acquired images with template pictures and maps of terrain are shown within the frameworks of navigation of unmanned vehicles or detection of signs of disasters.
Photo sensing and quorum sensing are integrated to control bacterial group behaviors (2019)

ABSTRACT Pseudomonas aeruginosa transitions between the free-swimming state and the sessile biofilm mode during its pathogenic lifestyle. We show that quorum sensing represses P. aeruginosa biofilm formation and virulence by activating expression of genes encoding the KinB-AlgB two-component system. Phospho-AlgB represses biofilm and virulence genes, while KinB dephosphorylates, and thereby, inactivates AlgB. We discover that the photoreceptor BphP is the kinase that, in response to light, phosphorylates and activates AlgB. Indeed, exposing P. aeruginosa to light represses biofilm formation and virulence gene expression. To our knowledge, P. aeruginosa was not previously known to detect light. The KinB-AlgB-BphP module is present in all Pseudomonads, and we demonstrate that AlgB is the cognate response regulator for BphP in diverse bacterial phyla. We propose that KinB-AlgB-BphP constitutes a “three-component” system and AlgB is the node at which varied sensory information is integrated. This study sets the stage for light-mediated control of P. aeruginosa infectivity.
Crystalline diamond growth in thin films deposited from a CH4/Ar rf plasma (1989)

Observation of single-crystal diamond growth in thin films obtained from the rf decomposition of a CH4/Ar plasma is reported. The films were deposited on Si substrates which were kept at 20 °C. Polycrystalline diamond grains are seen over the entire film. Single-crystal diffraction patterns obtained from larger grains all show {111} twinning.
Design and synthesis of conformationally constrained somatostatin analogs with high potency and specificity for .mu. opioid receptors (1986)

A series of cyclic, conformationally constrained peptides related to somatostatin were designed and synthesized in an effort to develop highly selective and potent peptides for the mu opioid receptor. The following new peptides were prepared and tested for their mu opioid receptor potency and selectively in rat brain binding assays: D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (2, CTOP); D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (3, CTAP); D-Phe-Cys-Tyr-D-Trp-Nle-Thr-Pen-Thr-NH2 (4); D-Phe-Cys-Tyr-D-Trp-Lys-Val-Pen-Thr-NH2 (5); D-Phe-Cys-Tyr-D-Trp-Lys-Gly-Pen-Thr-NH2 (6); D-Phe-Cys-Tyr-Trp-Lys-Thr-Pen-Thr-NH2 (7); D-Tyr-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr-OH (8); D-PhGly-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 (9); and D-PhGly-Pen-Phe-D-Trp-Lys-Thr-Cys-Thr-OH (10). The most selective peptide, 2 (CTOP), displayed both high affinity (IC50 = 3.5 nM) and exceptional selectivity (IC50 delta/IC50 mu = 4,000) for mu opioid receptors. Furthermore, 2 exhibited very low affinity for somatostatin receptors in the rat brain (IC50 greater than 24,000 nM), with an IC50 somatostatin/IC50 mu receptor selectivity of 8,750. These conformationally constrained cyclic peptides should provide new insight into the structural and conformational requirements for the mu opioid receptor and the physiological role of this receptor.
Context Aware Routing of Enterprise User Communications (2007)

This paper develops a context aware framework to address the diverse communication needs of a modern enterprise. Such enterprises are characterized by workers in different locations, subject to different policies, using different communication devices, and having varying degrees of skill sets. This diversity poses challenges in finding the most effective human worker (agent) for tasks like fielding a customer request, helping another agent with additional expert knowledge, or more generally help complete a task like a supply chain exception. We focus on the problem of routing communications to the most effective agent using a spectrum of contextual knowledge: availability, media type, activity, expertise, and location. We determine an optimal 'request-to-agent' routing based on several metrics of effectiveness depending on the communication context. The optimal agent is selected to communicate on a specific media who minimizes the expected duration of interaction while maximizes the probability of successful call completion. Based on our model we have conducted simulations involving context aware and non-context aware routing scenarios. The results indicate that the context aware routing outperforms other conventional request-routing techniques. The work presented here can impact routing algorithms, as well as address problems related to enterprise staffing and temporal variation of context for the agent
Systematic screening for mutations in the glycine receptor α2 subunit gene (GLRA2) in patients with schizophrenia and other psychiatric diseases (2001)

The glycine receptor, which is a member of the ligand-gated ion channel superfamily, mediates synaptic inhibition in the spinal cord and other brain regions. This superfamily has been implicated in the pathogenesis of schizophrenia and other psychiatric diseases. The complete coding sequence and splice junctions of the GLRA2 gene were scanned by DOVAM-S, a form of SSCP analysis with sufficient redundancy to detect virtually all mutations. Those analyses were performed in 113 patients with schizophrenia, and in pilot studies of patients with bipolar illness, alcoholism, puerperal psychosis, autism, and attention-deficit hyperactivity disorder (533 kb total scanned sequences). We detected three sequence changes in the coding region, all resulting in silent mutations: C894T in exon 5, C1134T in exon 7, and C1476T in exon 9. These do not alter the structure or the expression of the protein. It is unlikely that mutations in the coding region and splice junction of GLRA2 gene are associated with schizophrenia and other psychiatric diseases.
Laminin, a noncollagenous component of epithelial basement membranes synthesized by a rat yolk sac tumor. (1981)

Laminin, a glycoprotein antigenically similar or identical to a component of epithelial basement membranes, was identified as a major component of the abundant extracellular matrix synthesized by an experimentally induced rat yolk sac tumor. Immunocytochemical staining revealed laminin in cultured tumor cells as well as in their extracellular matrix. The presence of soluble laminin in the culture media of the tumor cells was demonstrated using metabolic labeling followed by identification by immunoprecipitation and sodium dodecyl sulfate:polyacrylamide gel electrophoresis. This revealed two polypeptides with molecular weights of approximately 200,000 and 400,000. These comigrated with the polypeptides of mouse laminin isolated previously. The yolk sac tumor tissue grown in vivo contained laminin in the tumor cells and in the extracellular material as evidenced by immunofluorescence and immunoperoxidase staining. Immunization with the tumor matrix resulted in an antiserum that contained antilaminin and natifibronectin and was made specific for laminin by absorption with fibronectin. This antiserum precipitated laminin polypeptides from culture medium of yolk sac tumour cells and stained basement membranes in rat tissues in a manner indistinguishable from antilaminin. The presence of laminin in rat yolk sac cells, the presumed origin of our yolk sac tumor, was studied in some detail. Laminin was found to be present in normal cells of the visceral as well as the parietal yolk sac layer and in their basement membranes suggesting, but not proving, that both types of cells have ability to synthesize laminin. Production of laminin and the presence of laminin-containing basement membrane material may be important for the biological behavior of the yolk sac tumor. This tumor will also be a useful source of laminin for chemical and biological characterization of this basement membrane protein.
Adam in Private: Secure and Fast Training of Deep Neural Networks with Adaptive Moment Estimation (2022)

Machine Learning (ML) algorithms, especially deep neural networks (DNN), have proven themselves to be extremely useful tools for data analysis, and are increasingly being deployed in systems operating on sensitive data, such as recommendation systems, banking fraud detection, and healthcare systems. This underscores the need for privacy-preserving ML (PPML) systems, and has inspired a line of research into how such systems can be constructed efficiently. However, most prior works on PPML achieve efficiency by requiring advanced ML algorithms to be simplified or substituted with approximated variants that are “MPC-friendly” before multi-party computation (MPC) techniques are applied to obtain a PPML systems. A drawback of this approach is that it requires careful fine-tuning of the combined ML and MPC algorithms, and might lead to less efficient algorithms or inferior quality ML (such as lower prediction accuracy). This is an issue for secure training of DNNs in particular, as this involves several arithmetic algorithms that are thought to be “MPCunfriendly”, namely, integer division, exponentiation, inversion, and square root extraction. In this work, we take a structurally different approach and propose a framework that allows efficient and secure evaluation of full-fledged state-of-the-art ML algorithms via secure multi-party computation. Specifically, we propose secure and efficient protocols for the above seemingly MPC-unfriendly computations (but which are essential to DNN). Our protocols are three-party protocols in the honest-majority setting, and we propose both passively secure and actively secure with abort variants. A notable feature of our protocols is that they simultaneously provide high accuracy and efficiency. This framework enables us to efficiently and securely compute modern ML algorithms such as Adam (Adaptive moment estimation) and the softmax function “as is”, without resorting to approximations. As a result, we obtain secure DNN training that outperforms state-of-the-art threeparty systems; our full training is up to 6.7 times faster than just the online phase of FALCON (Wagh et al. at PETS’21) and up to 4.2 times faster than Dalskov et al. (USENIX’21) on the standard benchmark network for secure training of DNNs. The potential advantage of our approach is even greater when considering more complex realistic networks. To demonstrate this, we perform measurements on real-world DNNs, AlexNet and VGG16, which are large networks containing millions of parameters. The performance of our framework for these networks is up to a factor of 26 ∼ 33 faster for AlexNet and 48 ∼ 51 faster for VGG16 to achieve an accuracy of 60% and 70%, respectively, when compared to FALCON. Even compared to CRYPTGPU (Tan et al. IEEE S&amp;P’21), which is optimized for and runs on powerful GPUs, our framework achieves a factor of 2.1 and 4.1 faster performance, respectively, on these networks.
Contact hole reticle optimization by using interference mapping lithography (IML) (2004)

The theory of interference mapping lithography (IML) is presented for low k<sub>1</sub> (k<sub>1</sub><0.4) contact hole imaging. IML with a coherent source is shown to be analogous to methods used in creating a Fresnel lens. With IML for a partially coherent source, the interference map is calculated by using the first eigenfunction of the transmission cross coefficient (TCC). From this interference map, clear 0° AFs and for clear 180° AFs are placed in the optimal location. Thus, IML is a method to place AFs via a model. From the interference map, a method for creating a CPL mask is demonstrated. Using IML, techniques to optimize a binary mask or a CPL mask are presented for maximizing the exposure latitude (EL) or depth of focus (DOF). These techniques are verified with simulation. Using IML for maximum EL, a CPL mask with 100nm (k<sub>1</sub>=0.39) contacts was created and exposed on an ASML /1100 ArF scanner using NA of 0.75 and Quasar illumination (&#963;<sub>in</sub>=0.72, &#963;<sub>out</sub>=0.92, span angle=20°). Measurements on the exposed wafers show that IML CPL results in printing 100nm contacts through pitch (200nm minimum pitch to isolated) with 0.45&mu;m DOF at 10% EL.
Conversion of (.pi.-allyl)nickel complexes to (.pi.-arene)nickel complexes (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConversion of (.pi.-allyl)nickel complexes to (.pi.-arene)nickel complexesS. T. Lin, T. J. Groshens, and K. J. KlabundeCite this: Inorg. Chem. 1984, 23, 1, 1Publication Date (Print):January 1, 1984Publication History Published online1 May 2002Published inissue 1 January 1984https://pubs.acs.org/doi/10.1021/ic00169a001https://doi.org/10.1021/ic00169a001research-articleACS PublicationsRequest reuse permissionsArticle Views166Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Serologic responses to SARS-CoV-2 infection among hospital staff with mild disease in eastern France (2020)

Background: The serologic response of individuals with mild forms of SARS-CoV-2 infection is poorly characterized. Methods: Hospital staff who had recovered from mild forms of PCR-confirmed SARS-CoV-2 infection were tested for anti-SARS-CoV-2 antibodies using two assays: a rapid immunodiagnostic test (99.4% specificity) and the S-Flow assay (~99% specificity).The neutralizing activity of the sera was tested with a pseudovirus-based assay. Results: Of 162 hospital staff who participated in the investigation, 160 reported SARS-CoV- 2 infection that had not required hospital admission and were included in these analyses. The median time from symptom onset to blood sample collection was 24 days (IQR: 21-28, range 13-39). The rapid immunodiagnostic test detected antibodies in 153 (95.6%) of the samples and the S-Flow assay in 159 (99.4%), failing to detect antibodies in one sample collected 18 days after symptom onset (the rapid test did not detect antibodies in that patient). Neutralizing antibodies (NAbs) were detected in 79%, 92% and 98% of samples collected 13-20, 21-27 and 28-41 days after symptom onset, respectively (P=0.02). Conclusion: Antibodies against SARS-CoV-2 were detected in virtually all hospital staff sampled from 13 days after the onset of COVID-19 symptoms. This finding supports the use of serologic testing for the diagnosis of individuals who have recovered from SARS-CoV-2 infection. The neutralizing activity of the antibodies increased overtime. Future studies will help assess the persistence of the humoral response and its associated neutralization capacity in recovered patients.
Biochemical pathways of apoptosis: nicotinamide adenine dinucleotide-deficient cells are resistant to tumor necrosis factor or ultraviolet light activation of the 24-kD apoptotic protease and DNA fragmentation. (1996)

The function of nicotinamide adenine dinucleotide (NAD) and adenosine diphosphate (ADP) ribosylation reactions in the mechanism of apoptotic cell death is controversial, although one theory postulates an essential role for NAD depletion by poly-ADP-ribose polymerase. The present study examined the role of intracellular NAD in tumor necrosis factor (TNF) and ultraviolet (UV) light-induced activation of the 24-kD apoptotic protease (AP24) leading to internucleosomal DNA fragmentation and death. Our results demonstrate that nutritional depletion of NAD to undetectable levels in two leukemia lines (U937 and HL-60) renders them completely resistant to apoptosis. This was attributed to a block in the activation of AP24 and subsequent DNA cleavage. Normal cells show an elevation of ADP-ribosyl transferase (ADPRT) in both the cytosol and nucleus after exposure to TNF, but before DNA fragmentation. ADPRT activity as well as cell death was suppressed by an inhibitor specific for mono-ADPRT. Nuclei from NAD-depleted cells were still sensitive to DNA fragmentation induced by exogenous AP24, indicating a selective function for NAD upstream of AP24 activation in the apoptotic pathway. We confirmed a requirement for intracellular NAD, activation of ADPRT, and subsequent NAD depletion during apoptosis in KG1a, YAC-1, and BW1547 leukemia cell lines. However, this mechanism is not universal, since BJAB and Jurkat leukemia cells underwent apoptosis normally, even in the absence of detectable intracellular NAD. We conclude that TNF or UV light-induced apoptotic cell death is not due to NAD depletion in some leukemia cell lines. Rather, NAD-dependent reactions which may involve mono-ADPRT, function in signal transduction leading to activation of AP24, with subsequent DNA fragmentation and cell death.
Application of a Transparent Conductive Substrate with an Atomically Flat and Stepped Surface to Lateral Growth of an Organic Molecule: Vanadyl Phthalocyanine (2003)

The lateral growth of an organic molecule on a transparent conductive substrate—important for molecular electronics—is demonstrated using vanadyl phthalocyanine (VOPc) on epitaxial indium tin oxide (ITO) film with an atomically flat and stepped surface. The occurrence of two‐dimensional lateral growth is proved by the heights of the square‐shaped domains of VOPc (see Figure) stacked parallel to the ITO substrate.
bcl-2 alters the antigen-driven selection of B cells in mukappa but not in mu-only Xid transgenic mice (1996)

A point mutation in the pleckstrin homology domain of the mouse Bruton's tyrosine kinase (btk) gene results in an X-linked immune defect, Xid, characterized by immunologic unresponsiveness to polymeric carbohydrate Ags. In Xid mice, B cells specific for phosphocholine (PC) do not develop in peripheral lymphoid tissues because they either fail to be positively selected from the marrow or they are clonally deleted via an Ag-driven, receptor-mediated process. Overexpression of the bcl-2 gene allows PC-specific B cells to survive and mature in Xid mukappa anti-PC transgenic mice, but PC-specific B cells are not rescued by bcl-2 in Xid mu-only transgenic mice. The failure of bcl-2 to rescue PC-specific B cells, in mu-only transgenic mice suggests that either it does not correct the btk defect in the Ag-driven selection process that occurs in pre-B cells and/or in very immature B cells or that a btk-dependent proliferative phase is required for the selection and amplification of the PC-specific B cells in mu-only transgenic mice. The rescue of PC-specific B cells in mukappa transgenic mice indicates that bcl-2 can alter receptor-mediated B cell selection at late stages in B cell development. The rescued PC-specific B cells in Xid male mice do not exhibit an altered proliferation profile in response to B cell-stimulating agents compared with B cells from unmanipulated Xid mice; thus, they fail to respond to soluble anti-mu, or PC-dextran, but they proliferate in response to PC, anti-mu, or anti-id conjugated to Sepharose.
BalCon: A Distributed Elastic SDN Control via Efficient Switch Migration (2017)

Scalability and reliability are among the main concerns in large-scale Software Defined Networking (SDN) application scenarios. A common approach is to use multiple distributed controllers, each managing one static partition of the network. In this paper, we show that dynamic mapping can improve efficiency in managing traffic load variations. We then propose BalCon (Balanced Controller): an algorithmic solution designed to tackle and reduce the load imbalance among SDN controllers through proper SDN switch migrations. Simulations demonstrate that BalCon is lightweight from the computational point of view and reduces the load imbalance among SDN controllers (expressed as variance) by 40% by migrating only a small number of switches. We also built a realistic prototype of SDN controller, BalConController, based on the open-source SDN framework RYU.
Five- and six-coordinate complexes of iron(II) and -(III) with a macrocyclic tetradentate ligand (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFive- and six-coordinate complexes of iron(II) and -(III) with a macrocyclic tetradentate ligandDennis P. Riley, Philip H. Merrell, John A. Stone, and Daryle H. BuschCite this: Inorg. Chem. 1975, 14, 3, 490–494Publication Date (Print):March 1, 1975Publication History Published online1 May 2002Published inissue 1 March 1975https://pubs.acs.org/doi/10.1021/ic50145a008https://doi.org/10.1021/ic50145a008research-articleACS PublicationsRequest reuse permissionsArticle Views196Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts