gebhart/patrepeval huggingface dataset:
Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats (2004)

We investigated the chronic in vivo effect of resistin on insulin sensitivity and glucose metabolism by overexpressing resistin protein in male Wistar rats using intravenous administration of an adenovirus encoding mouse resistin. After 7 days of elevated resistin levels at a supraphysiological concentration, the animals displayed glucose intolerance and hyperinsulinemia during glucose tolerance tests, and insulin tolerance tests demonstrated an impaired glucose-lowering effect of insulin. The glucose clamp studies were performed at submaximal (4 mU/kg/min) and maximal (25 mU/kg/min) insulin infusion rates and demonstrated the presence of insulin resistance induced by elevated resistin levels. Indeed, the insulin-stimulated glucose infusion rate was decreased by 12-31%; suppression of hepatic glucose output was attenuated by 28-55%; and insulin suppression of circulating FFA levels was inhibited by 7%. Insulin receptor substrate-1 and -2 phosphorylation and Akt activation were impaired in muscle and adipose tissue. Interestingly, activation of AMP-activated protein kinase in skeletal muscle, liver, and adipose tissue was also significantly downregulated. Together, these results indicate that chronic "hyper-resistinemia" leads to whole-body insulin resistance involving impaired insulin signaling in skeletal muscle, liver, and adipose tissue, resulting in glucose intolerance, hyperinsulinemia, and hypertriglyceridemia. Thus elevated resistin levels in normal rats fed a regular chow diet produce many of the features of human syndrome X.
Design and Optimization of High Performance Adsorption-Based Thermal Battery (2013)

Electric vehicle (EV) technology faces a substantial challenge in terms of driving range, especially when the vehicle’s climate control system relies entirely on the onboard electric battery. Therefore, we are developing an advanced adsorption-based thermal battery (ATB) capable of delivering both heating and cooling for electric vehicles with minimal use of the electric battery bank. While adsorption based climate control systems offer the advantage of direct usage of primary thermal energy sources for operation, they typically have low COP values, and are often bulky and heavy. A compact and lightweight ATB is necessary to replace existing climate control systems in EVs that use electric battery for operation. In this paper, we present a detailed computational analysis of adsorption kinetics taking place within an adsorption bed that is capable of delivering large cooling and heating capacities by making use of novel adsorbents. The overall design of the adsorption bed, which is a critical element in achieving a high performance thermal battery, is also discussed. To make performance predictions, we characterized the adsorbents to obtain their thermophysical and transport properties as well as adsorption characteristics. The model consequently incorporates these measured properties to predict the performance variation as a function of time. This work provides the critical parameters affecting heating and cooling rates, and identifies avenues for further improvement in the overall performance of the thermal battery.
Analog amplitude-locked loop circuit to support RF energy solutions (2016)

This paper presents the description and theory of the novel amplitude-locked loop (ALL) circuit to support RF energy solutions as well as RF plasma and microwave heating applications. This analog control circuit includes scalar hot S-parameter measurements to lock to the best S11-value in the 2.45 GHz ISM band. The necessary architecture including a new amplitude discriminator circuit is presented in detail. The second part of the paper describes hardware solutions, one with discrete integrated circuits and the current solution, which is fully integrated in a patented C11N CMOS-IC. These ALL solutions were tested in low speed applications (e.g. lamps) and high speed systems (e.g. spark plugs). The measurement results of the ALL hardware solutions wind up this paper. These measurement results exemplify the very good quality of this novel amplitude-locked loop circuit for different dynamic loads.
Markov Random Fields for Vision and Image Processing (2011)

State-of-the-art research on MRFs, successful MRF applications, and advanced topics for future study. This volume demonstrates the power of the Markov random field (MRF) in vision, treating the MRF both as a tool for modeling image data and, utilizing recently developed algorithms, as a means of making inferences about images. These inferences concern underlying image and scene structure as well as solutions to such problems as image reconstruction, image segmentation, 3D vision, and object labeling. It offers key findings and state-of-the-art research on both algorithms and applications. After an introduction to the fundamental concepts used in MRFs, the book reviews some of the main algorithms for performing inference with MRFs; presents successful applications of MRFs, including segmentation, super-resolution, and image restoration, along with a comparison of various optimization methods; discusses advanced algorithmic topics; addresses limitations of the strong locality assumptions in the MRFs discussed in earlier chapters; and showcases applications that use MRFs in more complex ways, as components in bigger systems or with multiterm energy functions. The book will be an essential guide to current research on these powerful mathematical tools.
All-optical de-multiplexing of 10 Gbps data using III-V/SOI microdisk resonators (2011)

III-V/SOI microdisk resonators R. Kumar, 2 T. Spuesens, P. Mechet, J.-M. Fedeli, N. Olivier, P. Regreny, G. Roelkens, D. Van Thourhout, and G. Morthier Photonics Research Group, INTEC Department, Ghent University-IMEC, Sint-Pietersnieuwstraat 41, 9000 Ghent, Belgium Center for Nanoand Biophotonics (NB-Photonics), Ghent University, 9000 Ghent, Belgium CEA-LETI, Minatec Campus, 17 Rue des Martyrs, 38054 Grenoble, France Universite de Lyon, Institut des Nanotechnologies de Lyon INL-UMR5270, CNRS, Ecole Centrale de Lyon, Ecully, F-69134, France
Vortex Pump for Dilute Bose-Einstein Condensates (2007)

The formation of vortices by topological phase engineering has been realized experimentally to create the first two- and four-quantum vortices in dilute atomic Bose-Einstein condensates. We consider a similar system, but in addition to the Ioffe-Pritchard magnetic trap we employ an additional hexapole field. By controlling cyclically the strengths of these magnetic fields, we show that a fixed amount of vorticity can be added to the condensate in each cycle. In an adiabatic operation of this vortex pump, the appearance of vortices into the condensate is interpreted as the accumulation of a local Berry phase. Our design can be used as an experimentally realizable vortex source for possible vortex-based applications of dilute Bose-Einstein condensates.
Hybrid FM-polynomial phase signal modeling: parameter estimation and Cramer-Rao bounds (1999)

Parameter estimation for a class of nonstationary signal models is addressed. The class contains combination of a polynomial-phase signal (PPS) and a frequency-modulated (FM) component of the sinusoidal or hyperbolic type. Such signals appear in radar and sonar applications involving moving targets with vibrating or rotating components. A novel approach is proposed that allows us to decouple estimation of the FM parameters from those of the PPS, relying on properties of the multilag high-order ambiguity function (ml-HAF). The accuracy achievable by any unbiased estimator of the hybrid FM-PPS parameters is investigated by means of the Cramer-Rao lower bounds (CRLBs). Both exact and large sample approximate expressions of the bounds are derived and compared with the performance of the proposed methods based on Monte Carlo simulations.
Hierarchical Search for Word Alignment (2010)

We present a simple yet powerful hierarchical search algorithm for automatic word alignment. Our algorithm induces a forest of alignments from which we can efficiently extract a ranked k-best list. We score a given alignment within the forest with a flexible, linear discriminative model incorporating hundreds of features, and trained on a relatively small amount of annotated data. We report results on Arabic-English word alignment and translation tasks. Our model outperforms a GIZA++ Model-4 baseline by 6.3 points in F-measure, yielding a 1.1 BLEU score increase over a state-of-the-art syntax-based machine translation system. 1
Prestorage Heat Treatments Influence Free Sterols and Flavor Volatiles of Tomatoes Stored at Chilling Temperature (1996)

The objective of this study was to determine the effects of prestorage heat treatments on chilling tolerance of tomatoes. Mature-green `Agriset' tomato fruit ( Lycopersicon esculentum Mill.), either C 2 H 4 -treated or not, were immersed in 42C water for 60 min, held in 38C air for 48 hours, or not treated, and then stored at either 2C (chilled) or 13C (nonchilled) for 14 days before ripening at 20C. Heat-treated fruit stored at 2C and transferred to 20C ripened normally while nonheated fruit decayed before reaching red ripe. Color (a * /b * ratio), lycopene content, and internal quality characteristics of fruit were similar at the red-ripe stage irrespective of method of heat treatment. In red-ripe heat-treated fruit, free sterol levels were significantly higher in chilled fruit than in nonchilled fruit. Heating fruit in 38C air resulted in significantly higher levels of some free sterols compared with heating fruit in 42C water. Of the 15 flavor volatiles analyzed, six showed significantly decreased concentrations as a result of C 2 H 4 -treatment and seven showed decreased concentrations when stored at 2C before ripening. Some volatiles were decreased by the heat treatments. Prestorage short- and long-term heat treatments could allow for storage of mature-green tomatoes at lower temperatures with little loss of their ability to ripen normally.
A COMMERCIAL BREEDING PERSPECTIVE OF MAIZE IMPROVEMENT FOR DROUGHT STRESS TOLERANCE (2022)

As the most produced grain crop in the world, maize (Zea mays) isa cornerstone of the global agricultural economy. Technological innovationsin molecular genetics, environmental characterization, and predictive breedinghave continued to drive genetic gain in maize, even for target populations ofenvironments with high heterogeneity of water availability. Environments proneto drought stress remain key targets where genetic gain must continue to maintain a resilient food supply. Here we review advances towards improving maize drought tolerance; the review focused on molecular and physiological mechanisms underpinning drought tolerance, and methodologies that improve prediction of the genotype by environment interactions under drought conditions.
A compact ultra-wideband circularly polarized antenna array for vehicular communications (2023)

In this paper, a new compact ultrawideband (UWB) circularly polarized (CP) antenna array for vehicular communications is proposed. The antenna array consists of a 2 × 2 sequentially rotated T-shaped cross dipole, four parasitic elements, and a feeding network. By loading the T-shaped cross dipoles with parasitic rectangular elements with cut corners, the bandwidth can be expanded. On this basis, the radiation pattern can be improved by the topology with sequential rotation of four T-shaped cross-dipole antennas, and the axial ratio (AR) bandwidth of the antenna also can be further enhanced. In addition, due to the special topology that the vertical arms of all T-shaped cross dipoles are all oriented toward the center of the antenna array, the gain of proposed antenna is improved while the size of the antenna is almost the same as the traditional cross dipole. Simulated and measured results show that the proposed antenna has good CP characteristics, an impedance bandwidth for S<inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</inf> <−10 dB of about 106.1% (3.26:1, 1.57–5.12 GHz) and the 3-dB AR bandwidth of about 104.1% (3.17:1, 1.57–4.98 GHz), a wide 3-dB gain bandwidth of 73.3% as well as the peak gain of 8.6 dBic at 3.5 GHz. The overall size of antenna is 0.56λ × 0.56λ × 0.12λ (λ refers to the wavelength of the lowest operating frequency in free space). The good performance of this compact UWB CP antenna array is promising for applications in vehicular communications.
MicroRec: Efficient Recommendation Inference by Hardware and Data Structure Solutions (2021)

Deep neural networks are widely used in personalized recommendation systems.Unlike regular DNN inference workloads, recommendation inference is memory-bound due to the many random memory accesses needed to lookup the embedding tables.The inference is also heavily constrained in terms of latency because producing a recommendation for a user must be done in about tens of milliseconds.In this paper, we propose MicroRec, a high-performance inference engine for recommendation systems.MicroRec accelerates recommendation inference by (1) redesigning the data structures involved in the embeddings to reduce the number of lookups needed and (2) taking advantage of the availability of High-Bandwidth Memory (HBM) in FPGA accelerators to tackle the latency by enabling parallel lookups.We have implemented the resulting design on an FPGA board including the embedding lookup step as well as the complete inference process.Compared to the optimized CPU baseline (16 vCPU, AVX2-enabled), MicroRec achieves 13.814.7speedup on embedding lookup alone and 2.55.4speedup for the entire recommendation inference in terms of throughput.As for latency, CPU-based engines needs milliseconds for inferring a recommendation while MicroRec only takes microseconds, a significant advantage in real-time recommendation systems.
Deliberating the Diagnostic Dilemma of Heart Failure With Preserved Ejection Fraction (2020)

There is a lack of consensus on how we define heart failure with preserved ejection fraction (HFpEF), with wide variation in diagnostic criteria across society guidelines. This lack of uniformity in disease definition stems in part from an incomplete understanding of disease pathobiology, phenotypic heterogeneity, and natural history. We review current knowledge gaps and existing diagnostic tools and algorithms. We present a simple approach to implement these tools within the constraints of the current knowledge base, addressing separately (1) hospitalized individuals with rest congestion, where diagnosis is more straightforward; and (2) individuals with exercise intolerance, where diagnosis is more complex. Here, a potential role for advanced or provocative testing, including evaluation of hemodynamic responses to exercise is considered. More importantly, we propose focus areas for future studies to develop accurate and feasible diagnostic tools for HFpEF, including animal models that recapitulate human HFpEF, and human studies that both address a fundamental understanding of HFpEF pathobiology, and new diagnostic approaches and tools, as well. In sum, there is an urgent need to more accurately define the syndrome of HFpEF to inform diagnosis, patient selection for clinical trials, and, ultimately, future therapeutic approaches.
Effects of air embolism size and location on porcine hepatic microcirculation in machine perfusion (2014)

The handling of donor organs frequently introduces air into the microvasculature, but little is known about the extent of the damage caused as a function of the embolism size and distribution. Here we introduced embolisms of different sizes into the portal vein, the hepatic artery, or both during the flushing stage of porcine liver procurement. The outcomes were evaluated during 3 hours of machine perfusion and were compared to the outcomes of livers with no embolisms. Dynamic contrast-enhanced ultrasound (DCEUS) was used to assess the perfusion quality, and it demonstrated that embolisms tended to flow mostly into the left lobe, occasionally into the right lobe, and rarely into the caudate lobe. Major embolisms could disrupt the flow entirely, whereas minor embolisms resulted in reduced or heterogeneous flow. Embolisms occasionally migrated to different regions of the same lobe and, regardless of their size, caused a general deterioration in the flow over time. Histological damage resulted primarily when both vessels of the liver were compromised, whereas bile production was diminished in livers that had arterial embolisms. Air embolisms produced a dose-dependent increase in vascular resistance and a decline in oxygen consumption. This is the first article to quantify the impact of air embolisms on microcirculation in an experimental model, and it demonstrates that air embolisms have the capacity to degrade the integrity of donor organs. The extent of organ damage is strongly dependent on the size and distribution of air embolisms. The diagnosis of embolism severity can be safely and easily made with DCEUS.
Clinical‐histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium (2012)

In DG, loss of ICC is associated with delayed gastric emptying. Interstitial cells of Cajal or enteric nerve loss did not correlate with symptom severity. Overall clinical severity and nausea in IG is associated with a myenteric immune infiltrate. Thus, full thickness gastric biopsies can help define specific cellular abnormalities in gastroparesis, some of which are associated with physiological and clinical characteristics of gastroparesis.
1598: The Significance of the Extent of Capsular Invasion in Localized Prostate Cancer (2006)

You have accessJournal of UrologyDiscussed Poster, Wednesday, May 24, 2006, 1:00 - 4:00 pm1 Apr 20061598: The Significance of the Extent of Capsular Invasion in Localized Prostate Cancer Ahmad Shabsigh, Joseph A. Pettus, James A. Eastham, and Peter T. Scardino Ahmad ShabsighAhmad Shabsigh More articles by this author , Joseph A. PettusJoseph A. Pettus More articles by this author , James A. EasthamJames A. Eastham More articles by this author , and Peter T. ScardinoPeter T. Scardino More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33790-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1598: The Significance of the Extent of Capsular Invasion in Localized Prostate Cancer." The Journal of Urology, 175(4S), p. 515 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 515 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Ahmad Shabsigh More articles by this author Joseph A. Pettus More articles by this author James A. Eastham More articles by this author Peter T. Scardino More articles by this author Expand All Advertisement PDF downloadLoading ...
The LDBC Social Network Benchmark (2015)

The Linked Data Benchmark Council (LDBC) is now two years underway and has gathered strong industrial participation for its mission to establish benchmarks, and benchmarking practices for evaluating graph data management systems. The LDBC introduced a new choke-point driven methodology for developing benchmark workloads, which combines user input with input from expert systems architects, which we outline. This paper describes the LDBC Social Network Benchmark (SNB), and presents database benchmarking innovation in terms of graph query functionality tested, correlated graph generation techniques, as well as a scalable benchmark driver on a workload with complex graph dependencies. SNB has three query workloads under development: Interactive, Business Intelligence, and Graph Algorithms. We describe the SNB Interactive Workload in detail and illustrate the workload with some early results, as well as the goals for the two other workloads.
Cryobiology of tissues (1988)

There is considerable interest in the transplantation of mammalian tissues for the treatment of disease states and trauma and the correction of tissue malfunction. The logistics of tissue procurement for transplantation are such that some method of tissue preservation is highly desirable. To date, the most common method of preservation has been hypothermic storage, either cold storage above freezing (usually 4 °C) or else cryopreservation and storage in the frozen state (usually — 70 °C to — 196 °C). The advantage of hypothermic storage in the unfrozen state is that ice damage is avoided, but the disadvantage is that there is a limited storage duration of about 1 week or less (11, 19). The advantage of cryopreservation is that truly long-term preservation ranging from months to years can be obtained, while the disadvantage is in the lack of a complete understanding of the mechanism of cryoinjury, so that cryopreservation produces significant damage as a result of ice formation during the freezing process. Nevertheless, cryopreservation has decided advantages over refrigerated storage provided that effective methodologies can be developed for the specific tissue under consideration.
Loop Stiffness of Grinding Machine Developed for 450 mm Silicon Wafers (2016)

Increasing the wafer diameter from φ300 mm to φ450 mm is required to enhance semiconductor devices productivity. A high-stiffness rotary grinding machine equipped with water hydrostatic bearings was developed for a φ450 mm silicon wafer. The grinding machine has an upper structure consisting of a wheel spindle system and a lower structure consisting of a rotary worktable system. The spindle shaft creates both rotary and axial feeding motion. The upper and lower structures are clamped together rigidly by three kinematic couplings. A higher loop stiffness is required for the grinding machine because grinding the larger wafer requires a higher grinding force. This paper investigates the loop stiffness of the developed wafer grinding machine.
Decoration of Squalenoyl‐Gemcitabine Nanoparticles with Squalenyl‐Hydroxybisphosphonate for the Treatment of Bone Tumors (2021)

Therapeutic perspectives of bone tumors such as osteosarcoma remain restricted due to the inefficacy of current treatments. We propose here the construction of a novel anticancer squalene-based nanomedicine with bone affinity and retention capacity. A squalenyl-hydroxybisphosphonate molecule was synthetized by chemical conjugation of a 1-hydroxyl-1,1-bisphosphonate moiety to the squalene chain. This amphiphilic compound was inserted onto squalenoyl-gemcitabine nanoparticles using the nanoprecipitation method. The co-assembly led to nanoconstructs of 75 nm, with different morphology and colloidal properties. The presence of squalenyl-hydroxybisphosphonate enhanced the nanoparticles binding affinity for hydroxyapatite, a mineral present in the bone. Moreover, the in vitro anticancer activity was preserved when tested in commercial and patient-treated derived pediatric osteosarcoma cells. Further in vivo studies will shed light on the potential of these nanomedicines for the treatment of bone sarcomas.
Measuring environmental success (1992)

Abstract Process improvement, environmental results, and customer satisfaction all can—and need to—be measured in order to achieve total quality environmental management. This article details why and how to take such measures, with examples of leading company practices.
Gaussian relaxation method. I. Homopolar tetrahedral solids (1977)

We present a method for extending an empirical tight-binding theory to the calculation of densities of states of very large but finite systems. We also derive a set of bond-centered analytic wave functions which can be used to obtain realistic energy-dependent charge densities from a tight-binding calculation. As an example, we apply the method to a model homopolar tetrahedral solid representative of Ge.