gebhart/patrepeval huggingface dataset:
A simplified inverter model for on-line control and simulation (1991)

A simplified fundamental component model for sine triangle comparison pulse width modulation (PWM) inverters operating in the transition region is presented. The model is evaluated through experimental verification and bv comparing it with detailed simulations of AC motor drives. Results from a real time control application show that the model compensates for the reduced inverter gain due to bus voltage variation and operation in the pulse dropping region. Finally. a technique for third harmonic injection in a current regulated PWM (CRPWM) inverter is demonstrated. providing the incentive to investigate a simplified inverter model that incorporates third-harmonic effects.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
2nd Place Solution for SODA10M Challenge 2021 -- Continual Detection Track (2021)

In this technical report, we present our approaches for the continual object detection track of the SODA10M challenge. We adapt ResNet50-FPN as the baseline and try several improvements for the final submission model. We find that task-specific replay scheme, learning rate scheduling, model calibration, and using original image scale helps to improve performance for both large and small objects in images. Our team `hypertune28' secured the second position among 52 participants in the challenge. This work will be presented at the ICCV 2021 Workshop on Self-supervised Learning for Next-Generation Industry-level Autonomous Driving (SSLAD).
Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters (2003)

Emerging evidence supports a role for platelets in the progression of atherosclerosis in addition to an involvement in thrombotic vascular occlusion. Platelet Factor 4 (PF4), a chemokine released by activated platelets, stimulates several pro-atherogenic processes. Therefore, we examined the localization of PF4 and the homologous protein, Neutrophil Activating Protein-2 (NAP-2) in lesions representing the evolution of human atherosclerotic plaques. Carotid plaques from 132 patients with critical carotid stenosis and 6 autopsy specimens were studied. Clinical, histologic and immunohistochemical data were analyzed using a chi(2)-test. PF4 was detected in the cytoplasm of luminal and neovascular endothelium, in macrophages and in regions of plaque calcification. The presence of PF4 in macrophages and neovascular endothelium correlated with lesion grade (p = 0.004; p = 0.044). Staining of macrophages for PF4 correlated with the presence of symptomatic atherosclerotic disease (p = 0.028). In early lesions, PF4 was commonly found in macrophages of early lesions (Grade I/II), whereas NAP-2 was rarely present. In conclusion, correlation between PF4 deposition, lesion severity and symptomatic atherosclerosis suggests that persistent platelet activation may contribute to the evolution of atherosclerotic vascular lesions. These studies support the rationale for the chronic use of anti-platelet therapy in patients at risk for developing symptomatic atherosclerosis.
Globally Convergent Parallel MAP LP Relaxation Solver using the Frank-Wolfe Algorithm (2014)

Estimating the most likely configuration (MAP) is one of the fundamental tasks in probabilis-tic models. While MAP inference is typi-cally intractable for many real-world applica-tions, linear programming relaxations have been proven very effective. Dual block-coordinate descent methods are among the most efficient solvers, however, they are prone to get stuck in sub-optimal points. Although subgradient approaches achieve global convergence, they are typically slower in practice. To improve convergence speed, algorithms which compute the steepest -descent direction by solving a quadratic program have been proposed. In this paper we suggest to decouple the quadratic pro-gram based on the Frank-Wolfe approach. This allows us to obtain an efficient and easy to par-allelize algorithm while retaining the global con-vergence properties. Our method proves superior when compared to existing algorithms on a set of spin-glass models and protein design tasks. 1.
rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination (2017)

Failure of oligodendrocyte precursor cells (OPCs) to differentiate and remyelinate axons is thought to be a major cause of the limited ability of the central nervous system to repair plaques of immune-mediated demyelination in multiple sclerosis (MS). Current therapies for MS aim to lessen the immune response in order to reduce the frequency and severity of attacks, but these existing therapies do not target remyelination or stimulate repair of the damaged tissue. Thus, the promotion of OPC differentiation and remyelination is potentially an important therapeutic goal. Previous studies have shown that a recombinant human-derived monoclonal IgM antibody, designated rHIgM22, promotes remyelination, particularly of the spinal cord in rodent models of demyelination. Here, we examined the effects of rHIgM22 in remyelination in the brain using the mouse model of cuprizone-induced demyelination, which is characterized by spontaneous remyelination. The myelination state of the corpus callosum of cuprizone-fed mice treated with rHIgM22 was examined immediately after the end of the cuprizone diet as well as at different time points during the recovery period with regular food, and compared with that of cuprizone-fed animals treated with either vehicle or human IgM isotype control antibody. Mice fed only regular food were used as controls. We demonstrate that treatment with rHIgM22 accelerated remyelination of the demyelinated corpus callosum. The remyelination-enhancing effects of rHIgM22 were found across different, anatomically distinct regions of the corpus callosum, and followed a spatiotemporal pattern that was similar to that of the spontaneous remyelination process. These enhancing effects were also accompanied by increased differentiation of OPCs into mature oligodendrocytes. Our data indicate strong remyelination-promoting capabilities of rHIgM22 and further support its therapeutic potential in MS.
Hydrogen Trapping Behavior in Vanadium-added Steel (2003)

Hydrogen trapping and de-trapping behavior was investigated for steels with and without V. The de-trapping of hydrogen is very slow while the trapping presumably proceeds rapidly for steels containing VC precipitates. The activation energy for de-trapping is in the range of 33 to 35 kJ/mol. The trapped-hydrogen content and diffusible-hydrogen content in the steady state increase with increasing hydrogen entry rate into the steel. The density of hydrogen trapping sites decides the maximum trapped-hydrogen content; 9 ppm for 1% V steel tempered at peak secondary hardening temperature. Analysis of hydrogen embrittlement cracking tests in terms of hydrogen contents such as the critical hydrogen content should be performed on the specimens with uniform hydrogen distribution and must consider the nature of hydrogen whether it is trapped or diffusible.
Eukaryotic mRNA Processing (1997)

Abstract This volume focuses on the major aspects of post-transcriptional mRNA processing in the nucleus of eukaryotic cells. Each of the described mRNA reactions is required for proper gene expression and can also serve as a control point for regulating the expression of many genes, for example during embryonic development or in different cell types. The different chapters review the assembly of newly synthesized nuclear mRNA transcripts into hnRNP particles and catalytically active spliceosomes; the structure and mechanism of action of small nuclear ribonucleoprotein particles and protein factors that catalyse pre-mRNA splicing in mammalian cells and in yeast; the regulation of gene expression and generation of protein isoform diversity by alternative splicing; the mechanisms of 3' end cleavage and polyadenylation; the architecture of the cell nucleus in relation to these processes and to the localization of the relevant substrates and factors; the diverse mechanisms of RNA processing by ribozymes and their potential relevance for nuclear mRNA processing; the mechanism of spliced-leader addition by trans-splicing in nematodes and trypanosomes; and the process of insertion/deletion mRNA editing in kinetoplasmid protozoa. In each chapter, leading researchers have provided detailed, critical reviews of the history, experimental approaches, major advances, current ideas and models, as well as future directions, for each of these active areas of research.
Mode-Dependent Selective Detection of Humidity and Helium Using Electromagnetically Actuated Clamped Guided MEMS Resonators (2021)

Abstract In this work, we demonstrate a selective gas sensor based on monitoring two different detection mechanisms; absorption and thermal conductivity. To illustrate the concept, we utilize a resonator composed of a clamped-guided arch beam connected to flexural beams and a T-shaped moveable mass. The resonator has two distinct out-of-plane modes in which the mass motion dominates the first mode while the motion of the flexural beam dominates the second mode. A highly disperse graphene oxide (GO) solution is prepared and drop-casted over the moveable mass structure using the inkjet printer for humidity sensing. On the other hand, the He is detected using the hot flexural beams. The results show no significant effect of humidity on the flexural mode (FM) nor for He on the mass mode (MM). This indicates a new technique for selectivity and identification. The device shows good sensitivity (50.1% to 50% RH @ MM and 39.2% to 50% He @ FM: (Vac = 1.5V)), linearity, and repeatability with excellent selectivity. It is demonstrated that the FM has great potential for detecting and categorizing different gases according to their thermal conductivity. The demonstrated multimode MEMS resonator can be a promising approach for the development of smart, highly selective, and sensitive gas/chemical sensors.
Performance analysis of parallel interference cancellation detector in downlink MC-CDMA systems (2004)

This paper proposes two types of low-complexity iterative multiuser detectors for downlink MC-CDMA systems, based on parallel interference cancellation (PIC). It will be shown that per-carrier MMSE-PIC detector is equivalent to per-user MMSE-PIC detector in the fully loaded case, and per-carrier MMSE-PIC obtains the same BER performance as per-user MMSE-PIC with one tenth of computational complexity for lower loaded cases. In addition, EGC based PIC detector is 1 dB worse than per-user MMSE-PIC, however the complexity is about one half of per-user MMSE-PIC detector’s complexity for the fully loaded case and about one twentieth for lower loaded cases.
INTERLEUKIN-1α TISSUE LEVELS DURING ENDOTOXEMIA IN THE RAT. (1997)

Mester, Marcelo; Tomokins, Ronald G.; Gelfand, Jeffrev A.; Dinarello, Charles A.; Clark, Burton D.; Burke, John F. Author Information
Fluid Resuscitation and the Septic Kidney: The Evidence (2007)

Acute kidney injury (AKI) is a common complication of severe sepsis. Severe sepsis is the most common cause of AKI in ICU. The widely accepted and practiced initial cornerstone of treatment for septic AKI is fluid resuscitation. The biological rationale for fluid resuscitation in septic AKI is based on the assumption that septic AKI is an ischemic form of AKI and that increasing renal perfusion and oxygen delivery by means of fluid resuscitation will protect the kidney. Whether this is true, however, remains uncertain. In this paper, we discuss salient pathophysiological aspects of AKI, review the evidence available on the need for fluid resuscitation, the amount and the type of fluid that might be best suited to AKI and discuss all major aspects of fluid resuscitation for septic AKI in humans and experimental animals.
Autologous Fat Processing Via the Revolve System: Quality and Quantity of Fat Retention Evaluated in an Animal Model (2014)

The Revolve system produced physiologically compatible, preinjection fat with reduced contaminants and free oil in conjunction with high fat content. In an animal model, volume retention of Revolve-processed fat grafts was significantly greater than decanted samples. The Revolve system presents a fat-processing option that was less time-consuming, easier to use, and more efficient in this study than standard centrifugation or decantation.
SHG/2PF microscopy of single and multi-layer graphene (2012)

Since the discovery of graphene in 2004 by Novoselov and Geim, a lot of research emphasis has been directed towards its characterization. Most of the important scientific breakthroughs have been obtained on exfoliated graphene (produced via the well known ‘scotch tape’ method), nowadays, different synthetic routes have been developed to obtain largescale graphene. Among several optical techniques, Raman spectroscopy is the one most often employed to characterize the defects, number of graphene layers and other properties of the graphitic films regardless of their fabrication method. In this work, we will report on the microscopic imaging of the two-photon fluorescence (2PF) properties and the second harmonic generation (SHG) in both single layer and few layer graphene.
Local field-induced optical properties of Ag-coated CdS quantum dots (2006)

Local field-induced optical properties of Ag-coated CdS quantum dot structures are investigated. We experimentally observe a clear exciton peak due to the quantum confinement effect in uncoated CdS quantum dots, and surface plasmon resonance and red-shifted exciton peak in Ag-coated CdS composite quantum dot structures. We have calculated the Stark shift of the exciton peak as a function of the local field for different silver thicknesses and various sizes of quantum dots based on the effective-mass Hamiltonian using the numerical-matrix-diagonalization method. Our theoretical calculations strongly indicate that the exciton peak is red-shifted in the metal-semiconductor composite quantum dots due to a strong local field, i.e., the quantum confined Stark effect.
100 Gbps multi-band OFDM transmission over 1000 km of G.52 fibre and a cascade of five sub-wavelength OADMs (2014)

International audience
Effect of Added LiBOB on High Voltage (LiNi0.5Mn1.5O4) Spinel Cathodes (2011)

Lithium bis(oxalato)borate (LiBOB) was investigated as an additive to improve the performance of LiNi 0.5Mn 1.5O 4 cathodes cycled to high voltage (4.9 V vs Li). Incorporation of low concentrations of LiBOB (0.25-1.0%, wt) results in a significant improvement in the capacity retention and cycling efficiency of LiNi 0.5Mn 1.5O 4/Li cells. Electrochemical impedance spectroscopy indicates that the addition of LiBOB decreases cell impedance. Ex-situ surface analysis of cycled cells suggests that the cathode surface films are thinner in cells cycled with added LiBOB. The addition of LiBOB inhibits detrimental reactions of the electrolyte with the surface of LiNi 0.5Mn 1.5O 4 cathodes at high voltage. © 2011 The Electrochemical Society.
Dynamic Scene Analysis: Moving Object Detection and Tracking (2005)

The detection and classification of moving objects is an important area of research in computer vision. The problem assumes immense importance because of the fact that our visual world is dynamic and we constantly come across video scenes, which contain a finitely large number of moving objects. To segment, detect and track these objects from a video sequence of images is possibly the most important challenge that the vision experts confront today. In this chapter we present the problems and the possible solutions of each subtask in dynamic image analysis such as dynamic background modeling, object detection and tracking techniques. These systems find applications in video surveillance in security systems, traffic surveillance, industrial applications, and many others.
Abstract PL01-03: Earlier detection as a key to lower cancer death rates (2017)

Abstract Two disciplines within cancer research—secondary prevention and cancer therapeutics—have historically been viewed as distinct. I will argue that these two disciplines are intertwined and that their joint pursuit is the optimal way to reduce cancer deaths. At present, the preferred way to treat cancers, in fact the only way that generally cures patients, is surgery. It is therefore widely recognized that the detection of cancers prior to the onset of metastasis is vital to reducing cancer deaths. What is less widely recognized is that the detection of metastatic cancers can also be life-saving—as long as this detection occur priors to the formation of bulky metastatic disease. Therapies that only modestly extend life when administered to patients with measurable metastases can be curative when administered to patients with metastatic disease that is present but undetectable by imaging. Such therapies include conventional cytotoxic drugs as well as genome-targeted agents and immunotherapeutics. A new paradigm for designing clinical trials to test such agents in adjuvant settings will be described. Genome-based diagnostic approaches for detecting cancers earlier will be discussed, as these are integral to the design of the next generation of adjuvant trials. In aggregate, these issues support the importance of modulating the focus of cancer research and treatment from patients with advanced disease towards patients with less-advanced disease. They also highlight the importance of developing novel diagnostic approaches that will allow the detection of smaller tumors. Citation Format: Bert Vogelstein. Earlier detection as a key to lower cancer death rates [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr PL01-03. doi:10.1158/1538-7445.AM2017-PL01-03
Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney (2017)

ABSTRACT Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150,134 European ancestry individuals and sought significant evidence for independent replication in a further 228,245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9 and AKT2 , and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA . Combining large whole-blood gene expression resources totaling 12,607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in BP regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.
Characterizing the Effect of Temperature Increase on Polypyrrole Active Strength and Stress Rate (2009)

Conducting polymers can be utilized as actuators due to the materials’ ability to undergo volumetric change caused by an electrochemical stimulus. Polypyrrole is an attractive electroactive polymer and capable of producing large active stress. Its mechanical performance can be improved by increasing temperature. This work describes a custom built device that is capable of performing dynamic mechanical analyses and electrochemistry simultaneously. In addition, there is a temperature control system that heats (or cools) with Peltier thermoelectric devices controlled by a PID controller. In this study, we characterized the effect of temperature increase on polypyrrole actuation strength and stress rate. For approximately each increment of 10°C from 27–83°C, stiffness measurements and isometric tests in 1-butyl-3-methylimidazolium hexafluorophosphate were done with sample preloaded to about 4 MPa. Results showed that the stiffness decreased by 21% as the temperature was elevated from 25–80°C. The maximum charge per polymer volume increased by 983% as the temperature was increased from 27–75°C and started to level off past 75°C. The peak stress changed with temperature in a similar trend as maximum charge per volume. Peak stress was 0.2 MPa at 27°C and increased to 7 MPa as temperature was increased to 75°C. Moreover, the stress rate increased until 85°C. The results suggest that peak stress depends upon the ionic mobility as opposed to stiffness since both peak stress and charge start to plateau past 75°C.
TRANSLOCATION OF MRNA CODONS, I. THE PREPARATION AND CHARACTERISTICS OF A HOMOGENEOUS ENZYME (1969)

This report describes a convenient scheme for the further purification of an E. coli enzyme which is required for the translocation step in protein biosynthesis. The homogeneous enzyme translocase appears to be a relatively large monomeric protein, having a molecular weight of approximately 72,000, and acts in a catalytic fashion during protein synthesis. It is also one of the major soluble macromolecular constituents of rapidly growing E. coli, comprising more than 2 per cent of the protein in ribosome-free extracts. Further, the rate of in vitro protein synthesis is linearly dependent upon the concentration of the pure enzyme until approximately one molecule of translocase is present per ribosome in reaction mixtures.
Dual-band shared aperture reflector/reflectarray antenna: Designs, technologies and demonstrations for nasa's ACE radar (2013)

NASA's planned Aerosol, Cloud and Ecosystems (ACE) mission will provide RF measurements for studying the role of aerosols on cloud development. The space-borne radar requires a fixed-beam at W-band and a wide-swath (>100 km) scanning beam at Ka-band. The full scale antenna is comprised of a parabolic cylinder reflector/reflectarray with a fixed W-band feed and a Ka-band Active Electronic Scanning Array (AESA) feed. Cassegrain folded optics is employed to reduce the required mass, volume, mechanical complexity and cost. An innovative reflectarray design provides a focused low-loss pencil beam at W-band, and is RF transparent at Ka-band. The AESA transmit/receive (T/R) modules provide high RF output power and low noise figure. Several planar reflector/reflectarray prototypes were designed and fabricated to validate the novel reflectarray element/surface technology and design methodology. The measured W/Ka band reflector/reflectarray gains and patterns agree very well with predictions thereby confirming the viability of the full scale design.