gebhart/patrepeval huggingface dataset:
Effect of carrier concentration on the facilitated oxygen transport in a polymer membrane (1994)

Abstract Facilitated transport of oxygen in a solid Polymer membrane containing cobaltporphyrin (CoP) which carries oxygen specifically and reversibly, leads to permselectivity of oxygen against nitrogen in the membrane. The increase in concentration of the CoP carrier is expected to enhance the oxygen transport. The membranes of poly(octylmethacrylate‐co‐vinylimidazole) containing 0.8 ∼ 10 wt% CoP were prepared, and the effects of the CoP‐concentration on the transport and the diffusion constants of oxygen are studied. Although the induction period before the steady state of oxygen permeation was prolonged with the CoP concentration in the polymer membrane, the glass transition temperature (T g ) of the membrane was increased and the diffusion constants of oxygen were decreased with the CoP concentration to yield unexpected reduction of the oxygen permeation in the highly CoP loaded membrane.
Structure-Based Super-Resolution Recovery of Three-Photon Quantum States from Two-Fold Coincidences (2014)

The field of quantum information has been growing fast over the past decade. Optical quantum computation, based on the concepts of KLM and cluster states, has witnessed experimental realizations of larger and more complex systems in terms of photon number. Quantum optical systems, which offer long coherence times and easy manipulation of single qubits, allow us to probe quantum properties of the light itself and of the physical systems around it. Recently, a linear scheme for quantum computing, relying on the bosonic nature of particles, has been proposed and realized experimentally with photons. The ability to efficiently measure superpositions of quantum states consisting of several photons is essential to the characterization of such systems. In fact, the entire field of quantum information completely relies on the ability to recover quantum states from measurements. However, the characterization of quantum states requires many measurements, and often necessitates complicated measurements schemes; for example, characterizing qubits requires measurements. Here, we utilize structure, inherent to physically interesting quantum states of light, in order to reduce the complexity in the recovery of a quantum state. In particular, we devise a method enabling the recovery of three-photon quantum states from only two-fold correlation measurements in a single setting. The ability to take two-fold coincidences instead of three-fold offers the recovery of the quantum states in far less measurements and in a considerably higher SNR, because detection of two-photon events is much more likely than that of three-photon ones. The concept suggested here paves the way to further ideas on structure-based super resolution in quantum state tomography, such as recovering a quantum state in an unknown basis in a single setup and recovering the state of several photons without number resolving detectors.
Uplink sounding reference signal coordination to combat pilot contamination in 5G massive MIMO (2018)

To guarantee the success of massive multiple-input multiple-output (MIMO), one of the main challenges to solve is the efficient management of pilot contamination. Allocation of fully orthogonal pilot sequences across the network would provide a solution to the problem, but the associated overhead would make this approach infeasible in practical systems. Ongoing fifth-generation (5G) standardisation activities are debating the amount of resources to be dedicated to the transmission of pilot sequences, focussing on uplink sounding reference signals (UL SRSs) design. In this paper, we evaluate the performance of various UL SRS allocation strategies in practical deployments, shedding light on their strengths and weaknesses. Furthermore, we introduce a novel UL SRS fractional reuse (FR) scheme, denoted neighbour-aware (FR-NA). The proposed FR-NA generalizes the fixed reuse paradigm, and entails a trade-off between i) aggressively sharing some UL SRS resources, and ii) protecting other UL SRS resources with the aim of relieving neighbouring BSs from pilot contamination. Said features result in a cell throughput improvement over both fixed reuse and state-of-the-art FR based on a cell-centric perspective.
Abstract 2088: Kindlin-3 enhances breast cancer metastasis through upregulation of Twist-mediated tumor angiogenesis (2014)

Abstract The FERM domain containing protein, Kindlin-3, has been recognized as a major regulator of integrin function in hematopoietic cells but its role in neoplasia is totally unknown. We have examined the relationship between Kindlin-3 and breast cancer in mouse models and human tissues. Human breast tumors showed a ∼7-fold elevation in kindlin-3 mRNA compared to non-neoplastic tissue by quantitative polymerize chain reaction. At the protein level, Kindlin-3 was found to be expressed abundantly in breast cancer tissue, and its expression increases with the advancing stage of tumor development. Mining of the Oncomine database (www.oncomine.com) confirmed this association: Kindlin-3 was in the top 3 % of gene products elevated in breast cancer (p&amp;lt; 10-12). When Kindlin-3 was over-expressed in a breast cancer cell line, primary tumor growth and lung metastasis increased by 2.5- and 3-fold, respectively when implanted into mice compared to cells expressing vector alone. Mechanistically, the Kindlin-cells displayed a 2.2-fold increase in Vascular Endothelial Growth Factor (VEGF) secretion and B1 integrin activation. Increased VEGF secretion resulted from enhanced production of Twist, a transcription factor which promotes tumor angiogenesis. Knockdown of Twist diminished VEGF production and knockdown of B1 integrins diminished Twist and VEGF production by Kindlin-3 cells while non-targeting si-RNA had no effect on expression of these gene products. The activation of this signaling cascade resulted in the enhancement of breast cancer cell invasion, and tumor angiogenesis and metastasis. Hence, our studies established the pathway in which cross-talk between Kindlin-3 and B1 integrins activates the nuclear translocation of TWIST, which leads to enhanced VEGF-A production and secretion, macrophage infiltration as well as activation of the Epithelial-to-mesenchymal-transition (EMT) program. The activation of this signaling cascade culminates in enhanced breast cancer cell migration, invasion and tumor angiogenesis, all of which are required for tumor progression and metastasis. In summary, by analysis of human tissue samples and in vitro and in vivo studies, we have identified a novel role for Kindlin-3 in the progression of breast cancer. To our knowledge, this is the first demonstration of the presence and implication of Kindlin-3 in breast cancer or any cancer. Citation Format: Khalid Sossey-Alaoui, Elzbieta Pluskota, Gangarao Davuluri, Katarzyna Bialkowska, Mitali Das, Daniel Lindner, Edward F. Plow. Kindlin-3 enhances breast cancer metastasis through upregulation of Twist-mediated tumor angiogenesis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2088. doi:10.1158/1538-7445.AM2014-2088
Interplay of Polarity and Confinement in Asymmetric Catalysis with Chiral Rh Diene Complexes in Microemulsions (2021)

Microemulsions provide a unique opportunity to tailor the polarity and liquid confinement in asymmetric catalysis via nanoscale polar and nonpolar domains separated by a surfactant film. For chiral diene Rh complexes, the influence of counterion and surfactant film on the catalytic activity and enantioselectivity remained elusive. To explore this issue chiral norbornadiene Rh(X) complexes (X=OTf, OTs, OAc, PO<sub>2</sub> F<sub>2</sub> ) were synthesized and characterized by X-ray crystallography and theoretical calculations. These complexes were used in Rh-catalyzed 1,2-additions of phenylboroxine to N-tosylimine in microemulsions stabilized either exclusively by n-octyl-β-D-glucopyranoside (C<sub>8</sub> G<sub>1</sub> ) or a C<sub>8</sub> G<sub>1</sub> -film doped with anionic or cationic surfactants (AOT, SDS and DTAB). The Rh(OAc) complex showed the largest dependence on the composition of the microemulsion, yielding up to 59 % (90 %ee) for the surfactant film doped with 5 wt% of AOT as compared to 52 % (58 %ee) for neat C<sub>8</sub> G<sub>1</sub> at constant surfactant concentration. Larger domains, determined by SAXS analysis, enabled further increase in yield and selectivity while the reaction rate almost remained constant according to kinetic studies.
Precision Fabrication Techniques and Analysis on High-&lt;tex&gt;$Q$&lt;/tex&gt;Evanescent-Mode Resonators and Filters of Different Geometries (2004)

High-Q evanescent-mode resonators and filters are realized by both silicon micromachining and layer-by-layer polymer processing. Capacitively loaded cavities can be reduced to a size much smaller than a wavelength, but still have a much higher unloaded Q than lumped elements. The loaded resonators are utilized for reduced-size filters with a low insertion loss enabled by the relatively high-Q factor. The small fabrication tolerances of silicon micromachining and polymer stereolithography processing enable the realization of highly loaded evanescent-mode resonators and filters. A 14-GHz resonator micromachined in silicon has a volume of 5 mm /spl times/ 5 mm /spl times/ 0.45 mm, representing a resonant frequency reduction of 66.8% compared to an empty cavity of the same dimensions. The polymer-based fabrication is used to create resonators of different three-dimensional geometries with Q's up to 1940 and frequency reductions up to 49.9%. An insertion loss of 0.83 dB is measured in a 1.69% bandwidth filter created by polymer processing with a frequency reduction of 47% compared to an unloaded cavity. The frequency sensitivity to fabrication tolerances of these structures is also analyzed.
ChemInform Abstract: HETEROCYCLISCHE VERBINDUNGEN 13. MITT. PYRROLO(2,1‐B)THIAZOLTHIOALDEHYDE, SYNTH. UND SPEKTRALE UNTERSUCHUNGEN (1973)

Abstract Durch eine abgewandelte Vilsmeier‐Reaktion (Solvolyse mit NaHS) werden aus Pyrrolothiazolen wie z.B. (I) die 5‐Thiocarbaldehyde (II) dargestellt.
Markov random field models for hair and face segmentation (2008)

This paper presents an algorithm for measuring hair and face appearance in 2D images. Our approach starts by using learned mixture models of color and location information to suggest the hypotheses of the face, hair, and background regions. In turn, the image gradient information is used to generate the likely suggestions in the neighboring image regions. Either Graph-Cut or Loopy Belief Propagation algorithm is then applied to optimize the resulting Markov network in order to obtain the most likely hair and face segmentation from the background. We demonstrate that our algorithm can precisely identify the hair and face regions from a large dataset of face images automatically detected by the state-of-the-art face detector.
On the Position of Intelligent Reflecting Surfaces (2021)

We study the positional impact of an intelligent reflecting surface (IRS) on the achievable rate for single and multiple antenna systems. We show that in IRS-aided single antenna systems, it is always best to place the IRS as close as possible to the transmitter or receiver since the large-scale fading for IRS-reflected links is the main factor that characterizes the performance gain. However, for IRS-aided multiple antenna systems, the propagation environment has an important role in characterizing the efficient regions of IRS placement. In the case of a line-of-sight environment, the channel matrix turns out to be rank-deficient. Thus, both far and near IRS placements result in significant achievable rate improvements where the former provides a substantial additional degree-of-freedom, while the latter results in a power gain. Furthermore, as the wireless channel becomes richer with multipath, the rank of the channel matrix increases. Thus, the efficient far placement regions gradually shrink until they disappear in the case of a Rayleigh fading channel where IRS near placements become more efficient than far placements as they result in higher power gains.
Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo (2009)

Here, we report the surprising association of acute latrepirdine dosing with elevated levels of extracellular Abeta as measured in three independent neuron-related or neuron-derived systems, including the hippocampus of freely moving Tg2576 mice. Given the reported association of chronic latrepirdine treatment with improvement in cognitive function, the effects of chronic latrepirdine treatment on extracellular Abeta levels must now be determined.
Simple approach to three-color two-photon microscopy by a fiber-optic wavelength convertor (2016)

A simple approach to multi-color two-photon microscopy of the red, green, and blue fluorescent indicators was reported based on an ultra-compact 1.03-μm femtosecond laser and a nonlinear fiber. Inside the nonlinear fiber, the 1.03-μm laser pulses were simultaneously blue-shifted to 0.6~0.8 μm and red-shifted to 1.2~1.4 μm region by the Cherenkov radiation and fiber Raman gain effects. The wavelength-shifted 0.6~0.8 μm and 1.2~1.4 μm radiations were co-propagated with the residual non-converted 1.03-μm pulses inside the same nonlinear fiber to form a fiber-output three-color femtosecond source. The application of the multi-wavelength sources on multi-color two-photon fluorescence microscopy were also demonstrated. Overall, due to simple system configuration, convenient wavelength conversion, easy wavelength tunability within the entire 0.7~1.35 μm bio-penetration window and less requirement for high power and bulky light sources, the simple approach to multi-color two-photon microscopy could be widely applicable as an easily implemented and excellent research tool for future biomedical and possibly even clinical applications.
ChemInform Abstract: New Catalysts for the Asymmetric Aldol Reaction: Chiral Boranes Prepared from α,α‐Disubstituted Glycine Arenesulfonamides. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
MR imaging and scintigraphy of gene expression through melanin induction. (1997)

Gene transfer and expression in cell culture can be detected with MR imaging and scintigraphy. The proposed strategy of using an imaging marker gene may have a substantial effect on the noninvasive imaging of gene therapy.
Scaling Modeling of the Emitted Substance Dispersion Transported by Advection Caused by Non-homogeneous Wind Field and by Isotropic and Anisotropic Diffusion in Vicinity of Obstacles (2015)

A simple two-dimensional mathematical approach for source localization of contaminants in the vicinity of individual simple two-dimensional obstacles is proposed. The approach consists of scaling analysis of advectiondiffusion potential flows that can be used in the vicinity of two-dimensional cylindrical obstacles. Three different modeling scenarios are developed in order to simulate the effects of wind. Particularly, the model incorporates the cases of anisotropic diffusion and spatially and temporary inhomogeneous airflow speeds.
Tandem alkylation-reduction of 2-acylpyrroles. Convenient one-pot syntheses of 2-benzylpyrroles (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTandem alkylation-reduction of 2-acylpyrroles. Convenient one-pot syntheses of 2-benzylpyrrolesDoris P. Schumacher and Stan S. HallCite this: J. Org. Chem. 1981, 46, 25, 5060–5064Publication Date (Print):December 1, 1981Publication History Published online1 May 2002Published inissue 1 December 1981https://pubs.acs.org/doi/10.1021/jo00338a002https://doi.org/10.1021/jo00338a002research-articleACS PublicationsRequest reuse permissionsArticle Views430Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The Elusive Turkestan Lynx at the Northwestern Edge of Geographic Range: Current Suitable Habitats and Distribution Forecast in the Climate Change (2022)

The Turkestan lynx (Lynx lynx isabellina Blyth, 1847) is a rare and understudied subspecies of the Eurasian lynx occupying the mountains of Central and South Asia. This elusive felid’s northwestern range includes the Tien Shan and Zhetisu Alatau mountains in the border region of Kazakhstan, China, Kyrgyzstan, and Uzbekistan. As the first step to conserve this vulnerable carnivore, we have conducted the first full-scale research from 2013 until 2022 on its distribution in this region. Using 132 environmental predictors of 359 lynx sightings, we have created species habitat distribution models across the lynx’s northwestern range using machine learning approaches (Maximum Entropy—MaxEnt). Additionally, we created species distribution forecasts based on seven bio-climatic environmental predictors with each three different future global climate model scenarios. To validate these forecasts, we have calculated the changes in the lynx distribution range for the year 2100, making the first species distribution forecast for the Turkestan lynx in the area. Additionally, it provides insight into the possible effects of global climate change on this lynx population. Based on these distribution models, the lynx population in the Northern and Western Tien Shan and Zhetisu Alatau plays a significant role in maintaining the stability of the whole subspecies in its northwestern and global range, while the distribution forecast shows that most lynx distribution ranges will reduce in all future climate scenarios, and we might face the Turkestan lynx’s significant distribution range decline under the ongoing and advancing climate change conditions. For a future (year 2100) warming scenario of 3 deg. C (GCM IPSL), we observe a decrease of 35% in Kazakhstan, 40% in Kyrgyzstan, and 30% in China as the three countries with the highest current predicted distribution range. For a milder temperature increase of 1.5–2 deg. C. (GCM MRI), we observe an increase of 17% Kazakhstan, decrease of 10% in Kyrgyzstan, and 57% in China. For a cooling scenario of approx. 1–1.5 deg. C (GCM MIROC), we observe a decrease of 14% Kazakhstan, increase of 11% in Kyrgyzstan, and a decrease of 13% in China. These modeled declines indicate the necessity to create new and expand the existing protected areas and establish ecological corridors between the countries in Central and South Asia.
Comparison of lightning protection performance of carbon/epoxy laminates with a non-metallic outer layer (2018)

This study shows how a lightning protection layer can be designed to effectively mitigate lightning damage in underlying composite structures. A parametric study was performed to characterize critical lightning protection layer properties that improve composite lightning damage resistance. Simulated 50 kA and 200 kA lightning strikes to pitch-based carbon fiber paper (PCFP)-protected AS4/3506 carbon/epoxy composites were considered in this study. The lightning protection characteristics of various PCFP outer layers were assessed by varying in-plane and through-thickness properties: electrical and thermal conductivities, and electrical and thermal gap conductances. The predicted matrix decomposition in the outermost AS4/3506 ply was significantly reduced by increasing the PCFP in-plane electrical conductivity. While predicted lightning damage decreased slightly with a decrease in thermal gap conductance, varying the electrical gap conductance and the in-plane and through-thickness thermal conductivities did not significantly affect the damage development. Among various PCFP properties, the PCFP in-plane electrical conductivity was the most critical factor in reducing thermal damage development (thus, protecting the underlying AS4/3506 laminate). This parametric study demonstrates that it may be possible to tailor lightweight non-metallic lightning protection layers as an effective alternative to traditional metallic projection layers.
Hippocampal protein aggregation signatures fully distinguish pathogenic and wildtype UBQLN2 in amyotrophic lateral sclerosis (2022)

Abstract Mutations in the UBQLN2 gene cause X-linked dominant amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD) characterised by ubiquilin 2 aggregates in neurons of the motor cortex, hippocampus, and spinal cord. However, ubiquilin 2 neuropathology is also seen in sporadic and familial ALS or FTD cases not caused by UBQLN2 mutations, particularly C9orf72 -linked cases. This makes the mechanistic role of ubiquilin 2 mutations and the value of ubiquilin 2 pathology for predicting genotype unclear. Here we examine a cohort of 41 genotypically diverse ALS cases with or without FTD, including five cases with UBQLN2 variants (resulting in p.S222G, p.P497H, p.P506S, and two cases with p.T487I). Using multiplexed (5-label) fluorescent immunohistochemistry, we mapped the co-localisation of ubiquilin 2 with phosphorylated TDP-43 (pTDP-43), dipeptide repeat aggregates, and p62, in the hippocampus of controls (n=5), or ALS with or without FTD in sporadic (n=20), unknown familial (n=3), SOD1 -linked (n=1), FUS -linked (n=1), C9orf72 -linked (n=5), and UBQLN2 -linked (n=5) cases. We differentiate between i) ubiquilin 2 aggregation together with pTDP-43 or dipeptide repeat proteins, and ii) ubiquilin 2 self-aggregation promoted by UBQLN2 gene mutations that cause ALS/FTD. Overall, we describe a hippocampal protein aggregation signature that fully distinguishes mutant from wildtype ubiquilin 2 in ALS with or without FTD, whereby mutant ubiquilin 2 is more prone than wildtype to aggregate independently of driving factors. This neuropathological signature can be used to assess the pathogenicity of UBQLN2 gene variants and to understand the mechanisms of UBQLN2 -linked disease.
Reliability problems and Pareto-optimality in cognitive radar (Invited paper) (2016)

Cognitive radar refers to an adaptive sensing system exhibiting high degree of waveform adaptivity and diversity enabled by intelligent processing and exploitation of information from the environment. The next generation of radar systems are characterized by their application to scenarios exhibiting non-stationary scenes as well as interference caused by use of shared spectrum. Cognitive radar systems, by their inherent adaptivity, seem to be the natural choice for such applications. However, adaptivity opens up reliability issues due to uncertainties induced in the information gathering and processing. This paper lists some of the reliability aspects foreseen for cognitive radar systems and motivates the need for waveform designs satisfying different metrics simultaneously towards enhancing the reliability. An iterative framework based on multi-objective optimization is proposed to provide Pareto-optimal waveform designs.