gebhart/patrepeval huggingface dataset:
Génie des procédés durables : Du concept à la concrétisation industrielle (2010)

Dans l'industrie de production et plus particulierement dans l'industrie chimique existe un besoin urgent de procedes plus acceptables du point de vue de la preservation de l'environnement. Cette tendance vers ce qui est maintenant connu sous le nom de «green processes» necessite une evolution des concepts traditionnels d'efficacite des procedes vers une evaluation integrant la valeur economique de l'elimination des dechets a la source. La «chimie verte» est d'abord preventive, c'est-a-dire qu'elle privilegie la prevention de la pollution par rapport a l'elimination des dechets. L'introduction des procedes propres a trois objectifs distincts mais complementaires : - consommer moins de matiere premiere, - consommer moins d'energie, - generer le minimum de dechets et d'effluents.Une technologie propre peut etre atteinte par trois methodes differentes et complementaires : - l'optimisation du procede existant, - la substitution de technologies par d'autres moins polluantes,- la modification radicale du procede.Ce sont ces trois aspects qui sont developpes dans cet ouvrage.
Exploring the inner space of outer space: multi-length scale, multimodal characterization of Muonionalusta IVA iron meteorite (2021)

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Density Displays for Data Stream Monitoring (2008)

Abstract In many business applications, large data workloads such as sales figures or process performance measures need to be monitored in real‐time. The data analysts want to catch problems in flight to reveal the root cause of anomalies. Immediate actions need to be taken before the problems become too expensive or consume too many resources. In the meantime, analysts need to have the “big picture” of what the information is about. In this paper, we derive and analyze two real‐time visualization techniques for managing density displays: (1) circular overlay d isplays which visualize large volumes of data without data shift movements after the display is full, thus freeing the analyst from adjusting the mental picture of the data after each data shift; and (2) variable resolution density displays which allow users to get the entire view without cluttering. We evaluate these techniques with respect to a number of evaluation measures, such as constancy of the display and usage of display space, and compare them to conventional d isplays with periodic shifts. Our real time data monitoring system also provides advanced interactions such as a local root cause analysis for further exploration. The applications using a number of real‐world data sets show the wide applicability and usefulness of our ideas.
Plasma-aided manufacturing (1991)

The present and potential applications of plasma-aided manufacturing are discussed and described. Plasma-aided manufacturing is used for producing new materials with unusual and superior properties, for developing new chemical compounds and processes, for machining, and for altering and refining materials and surfaces. Plasma-aided manufacturing has direct applications to semiconductor fabrication, materials synthesis, welding, lighting, polymers, anticorrosion coatings, machine tools, metallurgy, electrical and electronics devices, hazardous waste removal, high-performance ceramics, and many other items in both the high-technology and the more traditional industries in the United States.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Synchronous and Asynchronous Manipulation Switching of Multiple Robotic Embodiment Using EMG and Eye Gaze (2022)

Through the use of multiple avatars and robots, the construction of an alter ego whose senses and movements are synchronized with those of the operator has been explored. There are two possible states of operation when manipulating those bodies as synchronous operation: multiple bodies are synchronized simultaneously, and asynchronous operation: a specific body is selectively operated. We propose a system that allows intuitive switching between the active robot and the operation state by Eye gaze and EMG. A two-stage pick-and-place task was performed with the proposed system, and task performance and subjective evaluation of embodiment were analyzed. To consider the coordinates of the tracker in the asynchronous operation of the robot arm, we performed a similar study for a coordinate condition: the absolute coordinate condition, where the coordinates of the tracker are stored in space, and the relative coordinate condition, where only the motion of the tracker is added.
Abstract 5782: Androgen receptor antagonists: Lead optimization and preclinical pharmacology (2010)

Abstract The development and progression of prostate cancer is known to be dependent on androgens and their signaling mediated by the androgen receptor (AR). The primary therapeutic intervention involves using agents that lower serum testosterone (e.g., LHRH agonists), often in concert with an AR antagonist, such as bicalutamide. Despite a favorable initial anti-tumor response, most patients progress to the advanced hormone-refractory disease. The development of resistance to anti-androgen therapy has been shown to be associated with an increase in the levels of both AR mRNA and protein. This observation supports the concept that an AR antagonist with a significant improvement in potency as compared to bicalutamide and a broader spectrum of in vivo anti-tumor activity, including the bicalutamide-refractory human prostate tumor xenografts, may provide a significant clinical advantage in the treatment of advanced prostate cancer. This presentation will describe structure-activity relationships in a novel tetracyclic series of androgen receptor antagonists leading up to the identification of BMS-779333. It is a potent AR full antagonist, which exhibited broad spectrum efficacy in four human prostate tumor xenograft models. BMS-779333 did not exhibit agonist activity for AR mutant isoforms. Tumors that failed bicalutamide treatment were shown to retain their sensitivity to respond to BMS-779333. Transcriptomic changes in LuCaP-35 tumors treated with BMS-779333 were closer to castration than with other drug treatments. Based on its overall profile, BMS-779333 was selected for further preclinical evaluation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5782.
Cervical Spine and Shoulder Pain (1990)

The complex problem of combined neck and shoulder pain was investigated in 26 operations in 13 patients who had a shoulder procedure (subacromial decompressions or rotator cuff repairs) and an anterior cervical spine fusion. This select group of complex patients illustrates the diagnostic studies required to determine whether the pain comes primarily from the cervical spine, shoulder, or both. Good pain relief was accomplished after 24 of the 26 surgical procedures (average follow-up, 4.3 years). In the 13 patients, eight presented with nearly equal neck and shoulder pain as the chief complaint, whereas in the remaining five patients, the initial complaint was predominantly neck pain with only minor shoulder involvement. The shoulder pain became more significant after the anterior cervical fusion in these five patients. This study emphasizes the need for a careful evaluation of patients with combined neck-shoulder pain syndrome in a systematic approach allowing appropriate treatment.
Effects of Urea on Selectivity and Protein–Ligand Interactions in Multimodal Cation Exchange Chromatography (2012)

Nuclear magnetic resonance (NMR) and molecular dynamics (MD) simulations were employed in concert with chromatography to provide insight into the effect of urea on protein-ligand interactions in multimodal (MM) chromatography. Chromatographic experiments with a protein library in ion exchange (IEX) and MM systems indicated that, while urea had a significant effect on protein retention and selectivity for a range of proteins in MM systems, the effects were much less pronounced in IEX. NMR titration experiments carried out with a multimodal ligand, and isotopically enriched human ubiquitin indicated that, while the ligand binding face of ubiquitin remained largely intact in the presence of urea, the strength of binding was decreased. MD simulations were carried out to provide further insight into the effect of urea on MM ligand binding. These results indicated that, while the overall ligand binding face of ubiquitin remained the same, there was a reduction in the occupancy of the MM ligand interaction region along with subtle changes in the residues involved in these interactions. This work demonstrates the effectiveness of urea in enhancing selectivity in MM chromatographic systems and also provides an in-depth analysis of how MM ligand-protein interactions are altered in the presence of this fluid phase modifier.
Surface tension of airway aspirates withdrawn during neonatal resuscitation reflects lung maturity (2013)

The indications for treatment of neonates with exogenous pulmonary surfactant are still discussed controversially. Some premature neonates are sufficiently treated by CPAP, others need conventional ventilation and/or surfactant. The available lung maturity tests have limitations. The captive bubble surfactometer (CBS) provides measurement of surface activity from rather small amounts of surfactant. This study aimed to determine surface activity from small volume aspirates of the upper airways of neonates by means of the CBS and to correlate the results with clinical data. Small upper airway aspirates from 159 neonates (gestational age 25-42 weeks) were withdrawn and concentrated 16.7-fold by ultracentrifugation and resuspension in saline. Surface activities after 5 min of adsorption were determined in the CBS and correlated to the perinatal data (e.g., gestational age, birth weight, gender), airway interventions (like CPAP, conventional ventilation) and surfactant treatment. Additionally, 27 samples were analyzed for surfactant specific phosphatidylcholine concentrations by using electrospray ionization tandem mass-spectroscopy. Surface activities show a significant correlation to gestational age, birth weight, and the need for airway interventions. Comparing the need for airway interventions versus surface activity, a receiver operating characteristic calculated a sensitivity of 0.77 and a specificity of 0.72 at a "cut off" of 44 mN/m. Surface activity correlates significantly with the phosphatidylcholine concentrations and the latter one correlates with the gestational age. Determination of surface activity from upper airway aspirates is feasible. Further clinical studies are needed to prove the predictive value of the method.
Data from Twist Overexpression Induces <i>In vivo</i> Angiogenesis and Correlates with Chromosomal Instability in Breast Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Aggressive cancer phenotypes are a manifestation of many different genetic alterations that promote rapid proliferation and metastasis. In this study, we show that stable overexpression of Twist in a breast cancer cell line, MCF-7, altered its morphology to a fibroblastic-like phenotype, which exhibited protein markers representative of a mesenchymal transformation. In addition, it was observed that MCF-7/Twist cells had increased vascular endothelial growth factor (VEGF) synthesis when compared with empty vector control cells. The functional changes induced by VEGF &lt;i&gt;in vivo&lt;/i&gt; were analyzed by functional magnetic resonance imaging (MRI) of MCF-7/Twist-xenografted tumors. MRI showed that MCF-7/Twist tumors exhibited higher vascular volume and vascular permeability &lt;i&gt;in vivo&lt;/i&gt; than the MCF-7/vector control xenografts. Moreover, elevated expression of Twist in breast tumor samples obtained from patients correlated strongly with high-grade invasive carcinomas and with chromosome instability, particularly gains of chromosomes 1 and 7. Taken together, these results show that Twist overexpression in breast cancer cells can induce angiogenesis, correlates with chromosomal instability, and promotes an epithelial-mesenchymal-like transition that is pivotal for the transformation into an aggressive breast cancer phenotype.&lt;/p&gt;&lt;/div&gt;
Chalcogenide-Nanowire-Based Phase Change Memory (2008)

We report fabrication of phase change random access memory (PRAM) using nanowires (NWs) of GeTe and In <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> . NWs were grown by a vapor-liquid-solid technique and ranged from 40 to 80 nm in diameter and several micrometers long. A dynamic switching ratio (on/off ratio) of 2200 and 2 times 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> was realized for GeTe and indium selenide devices, respectively. The programming power for the RESET operation is only tens of microwatts compared to the milliwatt power levels required by the conventional thin-film-based PRAM.
Selective determinants of inositol 1,4,5‐trisphosphate and adenophostin A interactions with type 1 inositol 1,4,5‐trisphosphate receptors (2010)

The 2'-phosphate of AdA is not a major determinant of its high affinity. R504 in the receptor, most likely via a cation-π interaction, contributes specifically to AdA binding.
New Fluorinated Resins for 157 nm Lithography Application (2003)

As part of a new generation of more transparent 157 nm resist platforms we are developing, a novel resist system is described that has higher transparency and contrast than AZ®FXTM 1000P. Using a new protecting group strategy, encouraging results have been obtained with both poly(α,α-bis(trifluoromethyl)bicyclo[2.2.1]hept-5-ene-2-ethanol) and a more transparent perfluorinated resin (TFR). These new resist systems show absorbance values as low as 1 μm-1 at 157 nm, have twice the contrast (i.e., 12 instead of 7) of AZ®FXTM 1000P, and have neither significant dark erosion nor do they switch to negative tone behavior within the dose range studied. The dry etch resistance of the TFR platform is found to be superior to a Standard DUV resist for polysilicon but somewhat lower for oxide etches. Features as small as 50 nm lines and spaces were resolved for slightly relaxed pitches (1:1.5 micron). By adjusting the base level it is possible to improve the photospeed by a factor of more than 10 while still maintaining a resolution of 70 nm L/S features.
Modelling Interactions via Commitments and Expectations (2011)

Organizational models often rely on two assumptions: openness and heterogeneity. This is, for instance, the case with organizations consisting of individuals whose behaviour is unpredictable, whose internal structure is unknown, and who do not necessarily share common goals, desires, or intentions. This fact has motivated the adoption of social-based approaches to modelling interaction in organizational models. The idea of social semantics is to abstract away from the agent internals and provide a social meaning to agent message exchanges. In this chapter, we present and discuss two declarative, social semantic approaches for modelling interaction. The first one takes a state-oriented perspective, and models interaction in terms of commitments. The second one adopts a rule-oriented perspective, and models interaction in terms of logical formulae expressing expectations about agent interaction. We use a simple interaction protocol taken from the e-commerce domain to present the functioning and features of the commitment- and expectation-based approaches, and to discuss various forms of reasoning and verification that they accommodate, and how organizational modelling can benefit from them.Request access from your librarian to read this chapter's full text.
One-Step Conversion of PyridineN-Oxides to Tetrazolo[1,5-a]pyridines (2006)

Pyridine N-oxides were converted to tetrazolo[1,5-a]pyridines in good to excellent yield by heating in the presence sulfonyl or phosphoryl azides and pyridine in the absence of solvent. Various sulfonyl and phosphoryl azides were screened for reactivity under a standard set of conditions. Diphenyl phosphorazidate was the most convenient reagent and gave high yields. Reaction optimization, scope, and scalability are discussed.
MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins (2017)

The immediate early gene activity-regulated cytoskeletal protein (Arc)/Arg3.1 and the neurotrophin brain-derived neurotrophic factor (BDNF) play important roles in synaptic plasticity and learning and memory in the mammalian brain. However, the mechanisms by which BDNF regulates the expression of Arc/Arg3.1 are unclear. In this study, we show that BDNF acts via the ERK1/2 pathway to activate the nuclear kinase mitogen- and stress-activated protein kinase 1 (MSK1). MSK1 then induces Arc/Arg3.1 expression via the phosphorylation of histone H3 at the Arc/Arg3.1 promoter. MSK1 can also phosphorylate the transcription factor cyclic-AMP response element-binding protein (CREB) on Ser133. However, this is not required for BDNF-induced Arc.Arg3.1 transcription as a Ser133Ala knockin mutation had no effect on Arc/Arg3.1 induction. In parallel, ERK1/2 directly activates Arc/Arg3.1 mRNA transcription via at least one serum response element on the promoter, which bind a complex of the Serum Response Factor (SRF) and a Ternary Complex Factor (TCF).
Hyper‐thermostability of CutA1 protein, with a denaturation temperature of nearly 150 °C (2006)

We found that the CutA1 protein, from Pyrococcus horikoshii (PhCutA1), has an extremely high denaturation temperature (T(d)) of nearly 150 degrees C, which exceeds the highest record determined by DSC by about 30 degrees C. To elucidate the mechanism of the ultra-high stability of PhCutA1, we analyzed the crystal structures of CutA1 proteins from three different sources, P. horikoshii, Thermus thermophilus, and Escherichia coli, with different growth temperatures (98, 75, and 37 degrees C). This analysis revealed that the remarkably increased number of ion pairs in the monomeric structure contributes to the stabilization of the trimeric structure and plays an important role in enhancing the T(d), up to 150 degrees C, for PhCutA1.
A monolithic microring transmitter in 90 nm SOI CMOS technology (2013)

A silicon microring modulator with independent resonance and coupling tunability is monolithically integrated with a stacked CMOS driver. At 25Gbps, the OMA is −1.9dBm, the extinction ratio is 3.5dB, and the excess loss is 2.6dB.
Clinical Response Is a Meaningful Endpoint in Ulcerative Colitis Clinical Studies (2012)

The point estimates for the efficacy of VDZ in inducing clinical response, clinical remission, and mucosal healing in patients with prior anti-TNFa, immunosuppressive, or CS failure, were consistently superior to PBO at wk 6. In patients with a clinical response at wk 6, VDZ was superior to PBO in maintaining clinical response, clinical remission, and mucosal healing at wk 52, regardless of the type of prior treatment failure.
Personalized Session-Based Recommendation Using Graph Attention Networks (2021)

Personalized session-based recommendation systems aim to predict the next items that a user would be interested in based on previously recorded user interactions. The task contains two connotations. Firstly, “personalized” indicates the recommendation generating process does not involve other users. A recommendation system is expected to capture the preference patterns of the target user only. Secondly, “session-based” signifies that the preference patterns are expressed by sequences of items or interactions. Personalized session-based recommendation technologies are of high practical values in many application areas as explosive volumes of information available for customers. In this research we model user-item sessions using graphs and propose a novel graph neural network based model, namely, Personalized Session-based Recommendation using Graph Attention Networks (PSR-GAT). The PSR-GAT makes preferred item predictions by exploiting not only instantaneous preference patterns in the current session, but also more generic preference patterns in users' historical records. The proposed PSR-GAT is built on an attention mechanism basis with a consideration of item transition linkage. PSR-GAT does not have assumptions of preference expressions in sessions. Extensive experiments are conducted to evaluate the PSR-GAT model using three datasets, one is a vehicle infotainment dataset provided by the Ford Motor Company, and the other two are publicly accessible datasets. The performances of the PSR-GAT are compared with seven state-of-art methods for session-based recommendations. The results attest to the effectiveness and advantages of the PSR-GAT in the personalized session-based next interested items prediction.
Immersion lithography for laser mask writing (2006)

The viability of fluid management in immersion lithography for laser mask writing is demonstrated. The so-called “drag-a-drop” method is proposed, where a droplet of fluid is held between the moving lens and the mask due to surface tension forces without the need of a fluid circulation system. Theoretical calculations and experimental measurements show that a stable droplet can be held onto a 6mm diameter lens, typical in size for laser mask writing, translating at velocities up to 600mm∕s. Experiments also show that the stability of the droplet is greatly enhanced by the addition of a hydrophobic topcoat on the surface of the mask. Receding edge instabilities with the deposition of droplets similar to those seen in 193nm immersion lithography and a new advancing edge instability with complete drop breakup were seen at sufficiently high velocities. A stability map is presented that predicts the onset of these two instabilities as a function of the dimensionless capillary number, a ratio of the viscous forces to surface tensions forces, and Weber number, a ratio of inertial forces to surface tension forces. Moving the lens and attached droplet off and on the edge of the mask during the scanning process can be done repeatedly with no fluid loss. The constancy of the index of refraction of the droplet is an important consideration for immersion lithography. The index can change due to changes in temperature and composition. Calculations and experiment with 193nm immersion indicate that maintaining a constant index of refraction in laser mask writing with the drag-a-drop system is feasible. The application of immersion lithography appears to be a viable means of increasing the resolution of laser mask writing.
Design of a Fully-integrated BiCMOS/FBAR Reconfigurable RF Receiver Front-End (2005)

This article presents guidelines to design a dual-standard fully-integrated RF receiver front-end (RFFE). The designed front-end consists of two system selection integrated FBAR filters, a dual-standard low-noise amplifier (LNA), an active single-to-differential converter (SDC) and I/Q downconversion mixers. The active blocks use the 0.25-μm 60-GHz <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f<sub>T</sub></i> SiGe:C BiCMOS7RF process from STMicroelectronics. The proposed RFFE is targeted to DCS1800 (1805-1880MHz) and W-CDMA-FDD (2110-2170MHz) wireless standards. The availability of integrated FBAR filters in BAW technology, compatible with the used BiCMOS process, enables a very compact solution through a module integration
Regioisomeric α-hydroxy chlorohydrins from the reaction of mucochloric acid and guanosine (2006)

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