gebhart/patrepeval huggingface dataset:
Floating Point Tangent Implementation for FPGAs (2017)

This paper presents an implementation of the floating-point (FP) tangent function, optimized for an FPGA containing hard floating point (HFP) DSP Blocks. This function inputs values in the interval [-π/2,π/2], uses the IEEE-754 single-precision (SP) format, and has an accuracy conforming to OpenCL requirements. The presented architecture is based on a combination of mathematical identities and properties of the tangent function in FP. The resultant design outperforms generic polynomial approximation methods targeting the same resource utilization spectrum, and provides better resource trade-offs than classical CORDIC-based implementations. The presented work is widely available as part of the Intel DSP Builder Advanced Blockset.
Impact of Factor IXa Content On Function, Safety and Efficacy of Recombinant Factor IX Products. (2012)

Abstract Abstract 2233 Baxter has developed a new recombinant factor IX (rFIX) product (BAX 326) for treating patients with hemophilia B. The aim of the presented studies was to evaluate the function, safety and efficacy of BAX 326 compared to a commercially available rFIX regarding differences in activated FIX (FIXa) content. The FIXa concentration of BAX 326 was about 10 fold less than that of a commercial rFIX product. To address the influence of FIXa on functional FIX in vitro assays, the FIXa concentration of BAX 326 was increased. Samples were analyzed by one-stage clotting assay, non-activated partial thromboplastin time assay and thrombin generation assay. In all three assays, FIXa affected the potency determination for FIX, indicating that rFIX products should preferentially contain a low FIXa content. The thrombogenic potential of BAX 326 was assessed in rabbits using a modified Wessler Test at 750 IU/kg (10-fold human clinical dose). No thrombogenic potential was observed with BAX 326 (individual scores of 0), whereas the mean score for the commercially available rFIX was 0.5. After increasing the FIXa concentration of BAX 326 to equalize it with the commercially available rFIX, a mean score of 0.42 (individual scores 0 – 0.5) was determined. These data strongly suggest that the differences in preclinical thrombogenicity were caused by the higher FIXa content of the commercially available rFIX, thereby confirming earlier findings [1]. Efficacy of the rFIX products was studied in hemophilia B (FIX ko) mice that received prophylactic treatment with 75 IU/kg of BAX 326 or the commercially available rFIX. Treated animals were analyzed in two primary pharmacodynamic models: a carotid occlusion model and one using thrombelastography. In both models, results for the two groups were similar, demonstrating that despite its lower FIXa content, BAX 326 was as efficacious as a commercially available rFIX at 75 IU/kg (p&lt;0.0076). Disclosures: Auer: Baxter Innovations GmbH: Employment. Rottensteiner:Baxter Innovations GmbH: Employment. Schrenk:Baxter Innovations GmbH: Employment. Hoellriegl:Baxter Innovations GmbH: Employment. Schiviz:Baxter Innovations GmbH: Employment. Scheiflinger:Baxter Innovations GmbH: Employment. Schwarz:Baxter Innovations GmbH: Employment. Turecek:Baxter Innovations GmbH: Employment. Muchitsch:Baxter Innovations GmbH: Employment.
Isozyme Variation within and among Accessions of Annual Phalaris Species in North American Germplasm Collections (1999)

Accessions of annual Phalaris species in germplasm collections lack adequate genetic characterization for utilization. The objective of this study was to assess the level of isozyme variability of five annual Phalaris species, including 49 annual canarygrass ( P. canariensis L.; 2 n = 2 x = 12), 24 P. brachystachys Link. (2 n = 2 x = 12), 48 P. minor Retz. (2 n = 4 x = 28), 19 P. paradoxa L. (2 n = 2 x = 14), and P. angusta Nees ex Tris (2 n = 2 x = 14) accessions from North American germplasm collections. Eight enzymes were used to detect polymorphism within and among accessions by scoring the presence or absence of 62 bands. Polymorphism was detected in 6 of 19 bands in P. canariensis , 12 of 22 bands in P. brachystachys , 34 of 40 bands in P. minor , 19 of 29 bands in P. paradoxa , and 6 of 21 bands in P. angusta . Polymorphism was detected in 23 accessions (47%) P. canariensis , 15 accessions (63%) of P. brachystachys , 35 accessions (73%) of P. minor , four accessions (19%) of P. paradoxa and three accessions of P. angusta (100%). Within‐accession polymorphic indices ranged from 0 to 0.03 in P. canariensis , 0 to 0.02 in P. brachystachys , 0 to 0.06 in P. minor , 0 to 0.04 in P. paradoxa , and 0.01 to 0.04 in P. angusta . Jaccard's similarity coefficients ranged from 0.83 to 1.0 in P. canariensis, 0.78 to 1.0 in P. brachystachys , 0.47 to 1.0 in P. minor , 0.44 to 1.0 in P. paradoxa , and 0.81 to 0.86 in P. angusta . Little isozyme variation existed either within or among accessions of the four diploid species. Phalaris minor , an autotetraploid, possessed greater variation among accessions rather than within accessions. In summary, limited variation was detected by means of isozymes in these five annual Phalaris species obtained from North American germplasm collections.
On the network geography of the Internet (2011)

The geographic layout of the physical Internet inherently determines important network properties and traffic characteristics. To give insight into the geography of the Internet, we examine the spatial properties of the topology and routing. To represent the network we conducted a geographically dispersed traceroute campaign, and embedded the extracted topology into the geographic space by applying a novel IP geolocalization service, called Spotter. In this paper we present the frequency analysis of link lengths, quantify path circuitousness and explore the symmetry of end-to-end Internet routes.
[Cerebral ischemia in young patients]. (1992)

The clinical, angiographic and computed tomography (CT) examinations of 19 patients aged from 12 to 30 years with signs of ischaemic brain syndrome are presented. On the basis of these examinations and data obtained from literature it is supposed that in a majority of patients the disease is caused by basal arteriopathies + i.e. pathological changes in the wall of cerebral arteries, mainly of the circulus Willis. The features distinguishing this syndrome from ischaemic disease in adults are presented and discussed. These are first of all: sudden onset connected with physical effort, deep neurological deficit, narrowing or occlusion of basal cerebral arteries seen in angiography and signs of ischaemia within deep cerebral structures visible in CT. The methods of treatment are discussed, mainly STA-MCA anastomosis used in most cases. The results of treatment are discussed. Finally the problem of the cerebral ischaemic syndrome in young people is presented from the point of view of haemodynamics, principally in the aspect of haemodynamic reserve of cerebral blood flow.
Power monitoring in a feedforward photonic network using two output detectors (2023)

Programmable feedforward photonic meshes of Mach-Zehnder interferometers are computational optical circuits that have many classical and quantum computing applications including machine learning, sensing, and telecommunications. Such devices can form the basis of energy-efficient photonic neural networks, which solve complex tasks using photonics-accelerated matrix multiplication on a chip, and which may require calibration and training mechanisms. Such training can benefit from internal optical power monitoring and physical gradient measurement for optimizing controllable phase shifts to maximize some task merit function. Here, we design and experimentally verify a new architecture capable of power monitoring any waveguide segment in a feedforward photonic circuit. Our scheme is experimentally realized by modulating phase shifters in a 6 × 6 triangular mesh silicon photonic chip, which can non-invasively (i.e., without any internal "power taps") resolve optical powers in a 3 × 3 triangular mesh based on response measurements in only two output detectors. We measure roughly 3% average error over 1000 trials in the presence of systematic manufacturing and environmental drift errors and verify scalability of our procedure to more modes via simulation.
Perfluorochemical Liquid-Adenovirus Suspensions Enhance Gene Delivery to the Distal Lung (2011)

WE COMPARED LUNG DELIVERY METHODS OF RECOMBINANT ADENOVIRUS (RAD): (1) rAd suspended in saline, (2) rAd suspended in saline followed by a pulse-chase of a perfluorochemical (PFC) liquid mixture, and (3) a PFC-rAd suspension. Cell uptake, distribution, and temporal expression of rAd were examined using A549 cells, a murine model using luciferase bioluminescence, and histological analyses. Relative to saline, a 4X increase in transduction efficiency was observed in A549 cells exposed to PFC-rAd for 2-4 h. rAd transgene expression was improved in alveolar epithelial cells, and the level and distribution of luciferase expression when delivered in PFC-rAd suspensions consistently peaked at 24 h. These results demonstrate that PFC-rAd suspensions improve distribution and enhance rAd-mediated gene expression which has important implications in improving lung function by gene therapy.
VirtualTable (2015)

VirtualTable is a projection augmented reality installation where users are engaged in an interactive tower defense game. The installation runs continuously and is designed to attract people to a table, which the game is projected onto. Any number of players can join the game for an optional period of time. The goal is to prevent the virtual stylized soot balls, spawning on one side of the table, from reaching the cheese. To stop them, the players can place any kind of object on the table, that then will become part of the game. Depending on the object, it will become either a wall, an obstacle for the soot balls, or a tower, that eliminates them within a physical range. The number of enemies is dependent on the number of objects in the field, forcing the players to use strategy and collaboration and not the sheer number of objects to win the game.
Molecular Cloning and Complete Amino Acid Sequence of AP50, an Assembly Protein Associated with Clathrin-Coated Vesicles (1988)

AP50 is the 50,000-dalton protein component found in clathrin-coated vesicles as part of the coat assembly protein (AP) complex, AP-2. AP50 cDNA clones were isolated from rat brain cDNA libraries, and their nucleotide sequence was determined. The isolated cDNA clones represent the entire coding sequence for the rat brain AP50. They encode a polypeptide containing 435 amino acids with a molecular weight of 49,612 daltons. Comparison with the partially sequenced bovine brain AP50 shows a primary structure that is highly conserved. AP50 does not have detectable sequence similarity with other known kinases or with other proteins of known sequence.
MorePhone (2013)

We present MorePhone, an actuated flexible smartphone with a thin-film E Ink display. MorePhone uses shape memory alloys to actuate the entire surface of the display as well as individual corners. We conducted a participatory study to determine how users associate urgency and notification type with full screen, 1 corner, 2 corner and 3 corner actuations of the smartphone. Results suggest that with the current prototype, actuated shape notifications are useful for visual feedback. Urgent notifications such as alarms and voice calls were best matched with actuation of the entire display surface, while less urgent notifications, such as software notifications were best matched to individual corner bends. While different corner actuations resulted in significantly different matches between notification types, medium urgency notification types were treated as similar, and best matched to a single corner bend. A follow-up study suggested that users prefer to dedicate each corner to a specific type of notification. Users would like to personalize the assignment of corners to notification type. Animation of shape actuation significantly increased the perceived urgency of any of the presented shapes.
Multichannel Speech Enhancement With Own Voice-Based Interfering Speech Suppression for Hearing Assistive Devices (2022)

Enhancementof a desired speech signal in the presence of competing or interfering speech remains an unsolved problem, as it can be hard to determine which of the speech signals is the one of interest. In this paper, we propose a multichannel noise reduction algorithm which uses the presence of the user’s own voice signal, e.g. during conversations with the target speaker, as an asset to efficiently identify interfering speech and noise. Specifically, following the typical speech pattern in natural conversations, the presence of an own voice may indicate the absence of the target speech, hence undesired speech and noise can be identified and estimated during own voice presence. In contrast to conventional noise reduction systems, the proposed noise reduction systems use the user’s own voice to identify interfering speech that otherwise could be confused with the target speech. We demonstrate the performance of the proposed noise reduction systems in a comparison against state-of-the-art noise reduction systems in terms of beamforming performance for hearing assistive devices. The results show that the proposed beamforming scheme in particular outperforms state-of-the-art methods in terms of ESTOI and PESQ in situations with a target speaker and a strong interfering speaker.
Bacillus thuringiensis Cry34Ab1/Cry35Ab1 Interactions with Western Corn Rootworm Midgut Membrane Binding Sites (2013)

Combining two or more insecticidal proteins active against the same target pest is one tactic to delay the onset of resistance to either protein. We conclude that Cry34Ab1/Cry35Ab1 are compatible with Cry3Aa, Cry6Aa, or Cry8Ba for deployment as insect resistance management pyramids for in-plant control of western corn rootworm.
SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53 (2010)

Abrogation of p53 function occurs in almost all human cancers, with more than 50% of cancers harboring inactivating mutations in p53 itself. Mutation of p53 is indicative of highly aggressive cancers and poor prognosis. The vast majority of mutations in p53 occur in its core DNA binding domain (DBD) and result in inactivation of p53 by reducing its thermodynamic stability at physiological temperature. Here, we report a small molecule, SCH529074, that binds specifically to the p53 DBD in a saturable manner with an affinity of 1-2 microm. Binding restores wild type function to many oncogenic mutant forms of p53. This small molecule reactivates mutant p53 by acting as a chaperone, in a manner similar to that previously reported for the peptide CDB3. Binding of SCH529074 to the p53 DBD is specifically displaced by an oligonucleotide with a sequence derived from the p53-response element. In addition to reactivating mutant p53, SCH529074 binding inhibits ubiquitination of p53 by HDM2. We have also developed a novel variant of p53 by changing a single amino acid in the core domain of p53 (N268R), which abolishes binding of SCH529074. This amino acid change also inhibits HDM2-mediated ubiquitination of p53. Our novel findings indicate that through its interaction with p53 DBD, SCH529074 restores DNA binding activity to mutant p53 and inhibits HDM2-mediated ubiquitination.
Effect of Composition on the Properties of Amorphous Silicon Carbide at a Certain Optical Gap (1997)

The relationship between composition and optoelectric properties was investigated for a-SiC:H alloys with a constant optical gap ( E opt ) and different compositions. The compositions, hydrogen content ( C H ) and carbon content ( C C ), and the optical gap of a-SiC:H were successfully controlled independently. E opt of a-SiC:H can be expressed by a linear function of the compositions and a negative dependence of E opt on C C is observed for our samples. In the constant E opt system, C H increases with an increase in C C in spite of a rise in the substrate temperature. In particular, the increase in the Si–H 2 density is much more significant than that in the C–H bond density. This result suggests that the incorporated carbon atoms affect the bonding configuration between silicon and hydrogen. The film properties, such as photoconductivity and defect density, and solar cell performance become inferior both before and after light-soaking with an increase in C C , namely the Si–H 2 density. The Si–H 2 bond is an important factor to consider when determining the stability of a-SiC:H as well as a-Si:H and a-SiGe:H.
In-line rheological monitoring of fused deposition modeling (2018)

An in-line rheometer has been incorporated into a fused deposition modeling printer for the first time by designing a modified nozzle with a custom pressure transducer and a thermocouple for measuring the processed melt temperature. Additionally, volumetric flow rates and shear rates were monitored by counting the stepper motor pulses as well as the pulses from a custom filament encoder to account for filament slippage and skipped motor steps. The incorporation of the sensors and the design and development of the in-line rheometer are described; and pressures, temperatures, and viscosities within the 3D printing nozzle are presented. The in-line rheometer was validated against traditional, off-line rotational rheology and capillary rheology measurements by analyzing two polymeric materials: polycarbonate and high-impact polystyrene. A variety of rheological corrections were considered for the in-line rheometer, including entrance effects, non-Newtonian corrections, shear heating, pressure effects, and temperature fluctuations/inaccuracies. Excellent agreement was obtained between the in-line and off-line rheometers after applying the most critical corrections, which were found to be entrance effects, non-Newtonian corrections, and temperature inaccuracies. After applying the appropriate corrections, the in-line rheometer provides an accurate viscosity measurement that can be used for real-time monitoring and process control.
Steer-by-wire system integrated with active braking and driving-torque distribution (2010)

Steer-by-wire system (SBW), which is expected to improve passive and active safety for vehicle, has been discussed. Fault-tolerant capability of SBW is similarly required to a fly-by-wire of airplane because failures of SBW have a possibility to cause lack of steering function of the vehicle. Redundancy and diversity of steering function tend to require high cost, and it can postpone commercialization of SBW. This paper describes a diversified architecture for SBW fault-tolerance and its management that is integrated with pre-installed ESC and DTD. Effectiveness of the architecture and the management is investigated by a driving simulator experiment. This study shows a possibility to achieve reliability without excessive redundancy or additional diversity of the steering function.
Electro-optical effect in aluminum nitride waveguides (1992)

We fabricated thin optical layers in aluminum nitride by magnetron sputtering. Using the techniques of integrated optics, we characterized the layers and we determined the electro-optic coefficients of AlN: r13 = 0.67 pm/V and r33 = −0.59 pm/V.
ChemInform Abstract: 2‐Arylindene Metallocenes: Conformationally Dynamic Catalysts to Control the Structure and Properties of Polypropylenes (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Online Collaborative Prediction of Regional Vote Results (2016)

We consider online predictions of vote results, where regions across a country vote on an issue under discussion. Such online predictions before and during the day of the vote are useful to media agencies, polling institutes, and political parties, e.g., to identify regions that are crucial in determining the national outcome of a vote. We analyze a unique dataset from Switzerland. The dataset contains 281 votes from 2352 regions over a period of 34 years. We make several contributions towards improving online predictions. First, we show that these votes exhibit a bi-clustering of the vote results, i.e., regions that are spatially close tend to vote similarly, and issues that discuss similar topics show similar global voting patterns. Second, we develop models that can exploit this bi-clustering, as well as the features associated with the votes and regions. Third, we show that, when combining vote results and features together, Bayesian methods are essential to obtaining good performance. Our results show that Bayesian methods give better estimates of the hyperparameters than non-Bayesian methods such as cross-validation. The resulting models generalize well to many different tasks, produce robust predictions, and are easily interpretable.
SemEval-2010 Task 8: Multi-Way Classification of Semantic Relations Between Pairs of Nominals (2019)

In response to the continuing research interest in computational semantic analysis, we have proposed a new task for SemEval-2010: multi-way classification of mutually exclusive semantic relations between pairs of nominals. The task is designed to compare different approaches to the problem and to provide a standard testbed for future research. In this paper, we define the task, describe the creation of the datasets, and discuss the results of the participating 28 systems submitted by 10 teams.
Detecting simple motion using cellular neural networks (2002)

The general framework of motion detection based on the discrete-time samples of the moving image is defined. Four types of motion detection problem are studied. The simplest one is a model resembling the experiment of D.H. Hubel and T.N. Wiesel (1962) with a cat's retina for detecting the motion of an object having a given speed in a given direction. The most complicated case is the determination of the vertical and horizontal velocity components of a moving image. Various cloning template sequences are proposed for detecting different types of motion. The consecutive black and white image samples are fed to the input and to the initial state nodes of the cellular neural network, respectively. After the transients have decayed, the output gives the information necessary for detecting the presence or absence of a specific motion as well as for estimating the direction and the magnitude of the velocity vector. Conditions are analysed under which the detection is correct. The circuit realization of some motion detectors are discussed and the use of a programmable dual CNN structure is proposed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>