gebhart/patrepeval huggingface dataset:
Comparison survey of EVOO polyphenols and exploration of healthy aging-promoting properties of oleocanthal and oleacein (2022)

Olive oil is widely accepted as a superior edible oil. Great attention has been given lately to olive oil polyphenols which are linked to significant health beneficial effects. Towards a survey of Greek olive oil focusing on polyphenols, representative extra virgin olive oils (EVOOs) from the main producing areas of the country and the same harvesting period have been collected and analyzed. Significant differences and interesting correlations have been identified connecting certain polyphenols namely hydroxytyrosol, tyrosol, oleacein and oleocanthal with specific parameters e.g. geographical origin, production procedure and cultivation practice. Selected EVOOs polyphenol extracts, with different oleacein and oleocanthal levels, as well as isolated oleacein and oleocanthal were bio-evaluated in mammalian cells and as a dietary supplement in the <em>Drosophila in vivo</em> model. We found that oleocanthal and oleacein activated healthy aging-promoting cytoprotective pathways and suppressed oxidative stress in both mammalian cells and in flies.
Ablation of Persistent Atrial Fibrillation Targeting Low-Voltage Areas With Selective Activation Characteristics (2016)

Ablation of sites with distinct activation characteristics within/at borderzones of LVA in addition to PVI is more effective than conventional PVI-only strategy for persistent AF. PVI only seems to be sufficient to treat patients with left atrial low voltage < 10%.
Modulated scattering array antennas for mobile handsets (2005)

A concept of modulated scattering array antenna is proposed based on the modulated scattering technique. The array antenna consists of one antenna element and several modulated scattering elements (MSE). The configuration of the array antenna is very simple because only one branch of the front-end circuit is required. It is shown by experimental investigations that a 3-element modulated scattering array antenna composed of one λ/4 monopole and two λ/4 modulated scattering monopoles with λ/4 array spacing can provide diversity gain up to 8dB diversity gain at 0.1% of the cumulative distribution function in Rayleigh fading environment. The array antenna is suitable to the mobile handset applications where the space and the cost are strictly limited because of its simple configuration.
Acoustic damage detection in laser-cut CFRP composite materials (2012)

Carbon fiber reinforced plastics (CFRP) composite material, which is expected to reduce the weight of automotive, airplane and etc., was cut by laser irradiation with a pulsed-CO<sub>2</sub> laser (TRUMPF TFL5000; P=800W, 20kHz, &tau;=8&mu;s, &lambda;=10.6&mu;m, V=1m/min) and single-mode fiber lasers (IPG YLR-300-SM; P=300W, &lambda;=1.07&mu;m, V=1m/min)(IPG YLR- 2000-SM; P=2kW, &lambda;=1.07&mu;m, V=7m/min). To detect thermal damage at the laser cutting of CFRP materials consisting of thermoset resin matrix and PAN or PITCH-based carbon fiber, the cut quality was observed by X-ray CT. The effect of laser cutting process on the mechanical strength for CFRP tested at the tensile test. Acoustic emission (AE) monitoring, high-speed camera and scanning electron microscopy were used for the failure process analysis. AE signals and fractographic features characteristic of each laser-cut CFRP were identified.
Synthesis of hand grasp using functional neuromuscular stimulation (1989)

A functional neuromuscular stimulation system has been developed to provide grasp-release function in quadriplegic individuals. A single command input from the subject controls the stimulus levels to a number of electrodes, thus simultaneously activating several muscles. A method for synthesizing the command input to stimulus output relationship has been developed. The first step involves electrode profiling, which is a method for characterizing the output of an individual electrode/muscle combination. The electrodes are then grouped according to function and a set of rule based procedures is used to synthesize the basic grasp parameters. Results are presented demonstrating the output from lateral and palmar grasps developed by this method. The method has successfully resulted in grasping patterns that can be utilized functionally. Limitations of the method and future improvements are discussed.
Semantic multimodal compression for wearable sensing systems (2010)

Wearable sensing systems (WSS's) are emerging as an important class of distributed embedded systems in application domains ranging from medical to military. Such systems can be expensive and power hungry due to their multi sensor implementations that require constant use, yet by nature they demand low-cost and low-power implementations. Semantic multimodal compression (SMC) mitigates these metrics in terms of data size by leveraging the natural tendency of signals in many types of embedded sensing systems to be composed of phases. In our driving example of a medical shoe with an insole lined with pressure sensors, we find that the natural airborne, landing, and take-off segments have sharply different and repetitive properties. SMC models and compresses each segment independently, selecting the best compression scheme for each segment and thus reducing total transmission energy.
Ligand Effects and Ligand Design in Homogeneous Gold(I) Catalysis (2012)

Gold catalysis is considered one of the most important breakthroughs in organic synthesis during the past decade, but a rational understanding of ligand effects in gold catalysis is lacking. Most gold-catalyzed reactions go through three major stages: (i) electronic activation of alkyne (or allene) to generate a vinyl gold intermediate; (ii) protodeauration to generate the product and regenerate the cationic gold catalyst; (iii) decay of the active gold catalyst. Our research provides a clearer understanding of how ligands influence each of the three stages in the gold catalytic cycle. What is even more important, by not focusing on a particular gold-catalyzed reaction, we have been able to categorize most gold-catalyzed reactions and propose a ligand design protocol for each category of gold-catalyzed reactions.
Progrès médicaux et Ethique (2010)

conference intitule Progres medicaux et Ethique presente le samedi 2 octobre 2010 par le Pr Axel Kahn (Axel Kahn est un scientifique, medecin geneticien et essayiste francais. Directeur de recherche a l’INSERM, et ancien directeur de l’Institut Cochin, il est depuis le 20 decembre 2007 le president de l’Universite Paris Descartes).
Fabrication of 8 ch DFB-LD-PLC hybrid integrated module with active alignment optical connection (2008)

An 8 ch DFB-LD-PLC hybrid device was fabricated with high precision active alignment. The coupling loss between the DFB-LD and the PLC was 3.6 dB. All of 8 ch DFB-LDs oscillated appropriately.
Stimulation of fibronectin synthesis through the protein kinase c signaling pathway in normal and transformed human lung fibroblasts (1996)

We examined the role of the protein kinase C (PKC) signaling pathway in the stimulation of fibronectin synthesis in both normal and transformed human lung fibroblasts. Phorbol myristate acetate (PMA), a potent PKC activator, stimulated fibronectin synthesis in both normal and transformed fibroblasts in a time and dose dependent fashion. Down-regulation of PKC by prior exposure of cells to a high concentration of PMA blocked the increase in fibronectin synthesis and mRNA levels induced by PMA. Bisindolylmaleimide, a specific inhibitor of PKC, also abolished the PMA-induced fibronectin synthesis. 4 alpha-phorbol didecanoate, an inactive phorbol ester, failed to affect fibronectin synthesis. These data suggest that PMA stimulates fibronectin synthesis and gene expression through the PKC signaling pathway in both normal and transformed human lung fibroblasts.
A stepwise procedure for isolation of murine bone marrow and generation of dendritic cells (2014)

Bone marrow derived dendritic cells (BMDCs) are routinely employed in cell based assays to evaluate im-munomodulatory and anti-inflammatory activities. Hence, simplified, stepwise, defined and standardized methods are required for isolation of bone marrow cells from mice, propagating them in presence of growth factors and obtaining high and reproducible yields of BMDCs. Here, we describe a detailed, stepwise protocol with pictorial representation to isolate bone marrow from mouse femur and development of dendritic cells. Mouse bone marrow cells are cultured in presence of granulocyte-macrophage colony stimulating factor (GM-CSF) for 6 days to generate BMDCs.&amp;nbsp;
Preptin, another peptide product of the pancreatic β-cell, is osteogenic in vitro and in vivo (2006)

Several hormones that regulate nutritional status also impact on bone metabolism. Preptin is a recently isolated 34-amino acid peptide hormone that is cosecreted with insulin and amylin from the pancreatic beta-cells. Preptin corresponds to Asp(69)-Leu(102) of pro-IGF-II. Increased circulating levels of a pro-IGF-II peptide complexed with IGF-binding protein-2 have been implicated in the high bone mass phenotype observed in patients with chronic hepatitis C infection. We have assessed preptin's activities on bone. Preptin dose-dependently stimulated the proliferation (cell number and DNA synthesis) of primary fetal rat osteoblasts and osteoblast-like cell lines at periphysiological concentrations (>10(-11) M). In addition, thymidine incorporation was stimulated in murine neonatal calvarial organ culture, likely reflecting the proliferation of cells from the osteoblast lineage. Preptin did not affect bone resorption in this model. Preptin induced phosphorylation of p42/p44 MAP kinases in osteoblastic cells in a dose-dependent manner (10(-8)-10(-10) M), and its proliferative effects on primary osteoblasts were blocked by MAP kinase kinase inhibitors. Preptin also reduced osteoblast apoptosis induced by serum deprivation, reducing the number of apoptotic cells by >20%. In vivo administration of preptin increased bone area and mineralizing surface in adult mice. These data demonstrate that preptin, which is cosecreted from the pancreatic beta-cell with amylin and insulin, is anabolic to bone and may contribute to the preservation of bone mass observed in hyperinsulinemic states such as obesity.
Systemic deuteration of SCID mice using the water‐isotopologue deuterium oxide (D2O) inhibits tumor growth in an orthotopic bioluminescent model of human pancreatic ductal adenocarcinoma (2023)

Since its initial discovery as a natural isotopologue of dihydrogen oxide (<sup>1</sup> H<sub>2</sub> O), extensive research has focused on the biophysical, biochemical, and pharmacological effects of deuterated water (<sup>2</sup> H<sub>2</sub> O [D<sub>2</sub> O, also referred to as "heavy water"]). Using a panel of cultured human pancreatic ductal adenocarcinoma (PDAC) cells we have profiled (i) D<sub>2</sub> O-induced phenotypic antiproliferative and apoptogenic effects, (ii) redox- and proteotoxicity-directed stress response gene expression, and (iii) phosphoprotein-signaling related to endoplasmic reticulum (ER) and MAP-kinase stress response pathways. Differential array analysis revealed early modulation of stress response gene expression in both BxPC-3 and PANC-1 PDAC cells elicited by D<sub>2</sub> O (90%; ≤6 h; upregulated: HMOX1, NOS2, CYP2E1, CRYAB, DDIT3, NFKBIA, PTGS1, SOD2, PTGS2; downregulated: RUNX1, MYC, HSPA8, HSPA1A) confirmed by independent RT-qPCR analysis. Immunoblot-analysis revealed rapid (≤6 h) onset of D<sub>2</sub> O-induced MAP-kinase signaling (p-JNK, p-p38) together with ER stress response upregulation (p-eIF2α, ATF4, XBP1s, DDIT3/CHOP). Next, we tested the chemotherapeutic efficacy of D<sub>2</sub> O-based drinking water supplementation in an orthotopic PDAC model employing firefly luciferase-expressing BxPC-3-FLuc cells in SCID mice. First, feasibility and time course of systemic deuteration (30% D<sub>2</sub> O in drinking water; 21 days) were established using time-resolved whole-body proton magnetic resonance imaging and isotope-ratio mass spectrometry-based plasma (D/H)-analysis. D<sub>2</sub> O-supplementation suppressed tumor growth by almost 80% with downregulated expression of PCNA, MYC, RUNX1, and HSP70 while increasing tumor levels of DDIT3/CHOP, HO-1, and p-eIF2α. Taken together, these data demonstrate for the first time that pharmacological induction of systemic deuteration significantly reduces orthotopic tumor burden in a murine PDAC xenograft model.
Ion transport during cholera-induced ileal secretion in the dog (1971)

To assess the ion transport mechanism by which cholera causes the small bowel to secrete, ion transport rates and electrical potential difference (PD) were determined simultaneously in the normal and choleragen-treated dog ileum in vivo. The results indicate that, during cholera, HCO(3) is actively secreted (i.e., against both an electrical and a concentration gradient); Cl is also actively secreted, against a modest electrochemical gradient. Electrogenic pumping of one or both of these anions is probably responsible for an observed PD change of approximately 13 mv (lumen negative). Na secretion can be accounted for entirely by passive ion movement. K secretion can be partly explained by passive diffusion secondary to the negative intraluminal PD; however, its concentration in the secreted fluid is two to three times higher than expected on the basis of passive forces, suggesting a component of active K secretion. The PD response of the choleragen-treated ileum is normal in response to glucose, but there was no PD response to saline-free mannitol perfusion. This suggests that the normal differential permeability of the ileum to anions and cations may be altered by choleragen, although other explanations of this finding are also possible.
Electronic properties of the residual donor in unintentionally doped β-Ga2O3 (2016)

Electron paramagnetic resonance was used to study the donor that is responsible for the n-type conductivity in unintentionally doped (UID) β-Ga2O3 substrates. We show that in as-grown materials, the donor requires high temperature annealing to be activated. In partly activated materials with the donor concentration in the 1016 cm−3 range or lower, the donor is found to behave as a negative-U center (often called a DX center) with the negative charge state DX− lying ∼16–20 meV below the neutral charge state d0 (or Ed), which is estimated to be ∼28–29 meV below the conduction band minimum. This corresponds to a donor activation energy of Ea∼44–49 meV. In fully activated materials with the donor spin density close to ∼1 × 1018 cm−3, donor electrons become delocalized, leading to the formation of impurity bands, which reduces the donor activation energy to Ea∼15–17 meV. The results clarify the electronic structure of the dominant donor in UID β-Ga2O3 and explain the large variation in the previously reported donor activation energy.
Catecholamine and cortisol responses to lower extremity revascularization (1995)

The catecholamine response to lower extremity vascular surgery contributes to the development of postoperative hypertension and may also be important in the development of thrombotic complications.
Segment Routing Policy Architecture (2022)

Segment Routing (SR) allows a headend node to steer a packet flow
along any path. Intermediate per-flow states are eliminated thanks to
source routing. The headend node steers a flow into an SR Policy. The
header of a packet steered in an SR Policy is augmented with an
ordered list of segments associated with that SR Policy. This document
details the concepts of SR Policy and steering into an SR Policy.
ChemInform Abstract: Enhanced Extraction from Solid Foods and Biosuspensions by Pulsed Electrical Energy (2011)

Abstract Review: 100 refs.
Carminomycin I Is an Apoptosis Inducer That Targets the Golgi Complex in Clear Cell Renal Carcinoma Cells (2011)

Clear cell renal cell carcinoma (CCRCC) evolves due to mutations in the Von Hippel-Lindau (VHL) tumor suppressor gene. Although the loss of VHL enables survival and proliferation of CCRCC cells, it is also expected to introduce vulnerabilities that may be exploited for therapeutics discovery. To this end, we developed a high-throughput screen to identify small molecules derived from plants, microorganisms, and marine organisms to which CCRCC cells are sensitive. Screening over 8,000 compounds using this approach, we report here the identification of the microbially derived compound carminomycin I (CA) as an effective inhibitor of VHL-defective (VHL(-/-)) CCRCC cell proliferation. CA also induced apoptosis in CCRCC cells by a mechanism independent of p53 or hypoxia-inducible factor 2. We found that P-glycoprotein (P-gp) sequestered CA within the Golgi complex. Interestingly, Golgi sequestration was critical for the antiproliferative effects of CA and P-gp inhibitors abrogated this activity. Furthermore, CA induced cleavage of the Golgi protein p115 and the translocation of its C-terminal fragment to the nucleus. Finally, examination of the activity of the VHL-interacting Golgi protein, endoplasmic reticulum-Golgi intermediate compartment, ERGIC-53 showed that VHL could mediate protection from CA in CCRCC cells. Our natural product-based screening approach has revealed the P-gp-mediated localization of anticancer compounds within the Golgi in CCRCC cells as a potential strategy of targeting VHL-deficient CCRCC cells.
High Integrity SiO2Gate Insulator Formed by Microwave-Excited Plasma Enhanced Chemical Vapor Deposition for AlGaN/GaN Hybrid Metal–Oxide–Semiconductor Heterojunction Field-Effect Transistor on Si Substrate (2012)

High quality SiO 2 gate insulator has been demonstrated for GaN metal–oxide–semiconductor (MOS) transistor which has high performance with normally-off operation. The SiO 2 films formed on GaN by microwave-excited plasma enhanced chemical vapor deposition (MW-PECVD) and annealed after deposition exhibits a low-interface state density between SiO 2 and GaN, a high-breakdown field, and a high charge-to-breakdown. The SiO 2 films have been also applied to the gate insulator of AlGaN/GaN hybrid MOS heterojunction field-effect transistor (HFET) on Si substrate. The MOS-HFET show excellent properties with the threshold voltage of 4.2 V and the maximum field-effect mobility of 161 cm 2 V -1 s -1 .
Anion conducting multiblock copolymer membranes with partial fluorination and long head-group tethers (2016)

Multiblock copolymer with long head-group tethers were synthesized as anion exchange membranes with high ionic conductivity and good alkaline stability.
Massive MIMO as a cyber-weapon (2014)

A scheme for a multi-antenna jammer, jamming a SISO primary link working in TDD mode is presented. The jammer relies on reciprocity to estimate the channel to a terminal in the primary link blindly. The jammer can then beamform noise towards this user to degrade the performance of the primary link. Simulations show that, for certain scenarios, the proposed jammer can do the same damage to the primary link as an omnidirectional jammer, but with close to two orders of magnitude lower output power.
Identification of biochemical markers linked to neonicotinoid cross resistance in Bemisia tabaci (Hemiptera: Aleyrodidae) (2003)

The whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae), is a serious pest in many cropping systems world-wide and occurs in different biotypes. The most widespread one is the B-type, whereas the Q-biotype is nowadays still mostly restricted to Southern Spain. Neonicotinoid cross-resistance is known at a high level in Q-types from Spain and individual samples collected in Italy and Germany. Now we detected for the first time high neonicotinoid cross-resistance in a B-type from Israel. Target site resistance to imidacloprid using [(3)H]imidacloprid in nicotinic acetylcholine receptor (nAChR) binding assays could not be detected in any of these highly resistant strains. The impact of metabolizing enzymes such as esterases, glutathione S-transferases, and cytochrome P450-dependent monooxygenases in neonicotinoid resistance was studied biochemically with artificial substrates. Monooxygenase activity was increased 2-3-fold in moderately resistant strains (RF approximately 30) and even 5-6-fold in highly resistant strains (RF approximately 1,000). Only monooxygenase activity correlated with imidacloprid, thiamethoxam and acetamiprid resistance and, therefore, monooxygenases seem to be the only enzyme system responsible for neonicotinoid resistance in B. tabaci Q- and B-types. The oxidative degradation of imidacloprid in resistant Q-type strains could be confirmed by metabolism studies of [(14)C]imidacloprid in vivo. Five-hydroxy-imidacloprid could be detected as the only main metabolite. The insecticidal activity and binding affinity to nAChR of this compound was 10 times lower than imidacloprid itself in B. tabaci.
Analysis of Plasma Parameters and Conditions Required for Reconfigurable Antennas (2018)

As any electrical conductor, weakly ionized plasmas can be potentially used in RF antennas, but since plasmas can be turned on and off and their properties can be changed, plasmas could form a basis for reconfigurable antennas and arrays. Modeling of resonant dipole antennas shows that if the plasma conductivity exceeds a certain level, the antenna gain should be within a few dB of similar metallic antennas. Simulation of antenna arrays also demonstrates that cross-coupling between plasma array elements would be considerably lower than that between metallic dipoles, thus giving plasma an advantage.
Message-Passing De-Quantization With Applications to Compressed Sensing (2012)

Estimation of a vector from quantized linear measurements is a common problem for which simple linear techniques are suboptimal-sometimes greatly so. This paper develops message-passing de-quantization (MPDQ) algorithms for minimum mean-squared error estimation of a random vector from quantized linear measurements, notably allowing the linear expansion to be overcomplete or undercomplete and the scalar quantization to be regular or non-regular. The algorithm is based on generalized approximate message passing (GAMP), a recently-developed Gaussian approximation of loopy belief propagation for estimation with linear transforms and nonlinear componentwise-separable output channels. For MPDQ, scalar quantization of measurements is incorporated into the output channel formalism, leading to the first tractable and effective method for high-dimensional estimation problems involving non-regular scalar quantization. The algorithm is computationally simple and can incorporate arbitrary separable priors on the input vector including sparsity-inducing priors that arise in the context of compressed sensing. Moreover, under the assumption of a Gaussian measurement matrix with i.i.d. entries, the asymptotic error performance of MPDQ can be accurately predicted and tracked through a simple set of scalar state evolution equations. We additionally use state evolution to design MSE-optimal scalar quantizers for MPDQ signal reconstruction and empirically demonstrate the superior error performance of the resulting quantizers. In particular, our results show that non-regular quantization can greatly improve rate-distortion performance in some problems with oversampling or with undersampling combined with a sparsity-inducing prior.